FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Blackburn, JH
   Boemi, L
   Hall, WW
   Jeffords, K
   Hauck, RM
   Banducci, DR
   Graham, WP
AF Blackburn, JH
   Boemi, L
   Hall, WW
   Jeffords, K
   Hauck, RM
   Banducci, DR
   Graham, WP
TI Negative-pressure dressings as a bolster for skin grafts
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
AB Contoured wounds needing closure with skin grafts are often located in complex anatomic regions or are in unusual positions, which make conventional skin graft stabilization techniques cumbersome and ineffective. Often after 72 hours, a skin graft covered with a bolstered dressing has poor take secondary to shear stresses, as well as hematoma formation or serum collection, negating the effectiveness of the stabilizing dressing. The Food and Drug Administration has recently approved vacuum-assisted closure (V.A.C.), an innovative technique using negative pressure, for closure of chronic wounds. This reportedly leads to enhanced granulation tissue formation and consequently more rapid reepithelialization of wounds compared with conventional packing with saline-moistened gauze. Experimental studies have demonstrated increased oxygen tension, decreased bacterial counts, and increased granulation formation occurring under negative-pressure systems. Extending the use of this concept, we have coupled skin grafting with negative-pressure dressings for closure of large, complex open wounds. Our results indicate greater than 95% graft take in all patients in this study, This technique is extremely efficacious, with increased graft take due to total immobilization of the graft, thereby limiting shear forces, elimination of fluid collections, bridging of the graft, and decreased bacterial contamination. Moreover we have noted decreased edema in rotated muscle flaps, improved contour conformity, and shortened hospitalizations.
C1 Penn State Univ, Milton S Hershey Med Ctr, Penn State Geisinger Hlth Syst, Plast & Reconstruct Surg Sect,Dept Surg, Hershey, PA 17033 USA.
C3 Geisinger Health System; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Penn State Health
RP Blackburn, JH (通讯作者)，Penn State Univ, Milton S Hershey Med Ctr, Penn State Geisinger Hlth Syst, Plast & Reconstruct Surg Sect,Dept Surg, POB 850,MC H071, Hershey, PA 17033 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 15
TC 214
Z9 885
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 1998
VL 40
IS 5
BP 453
EP 457
DI 10.1097/00000637-199805000-00001
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ZL507
UT WOS:000073440400001
PM 9600426
DA 2026-07-24
ER
PT J
AU Morykwas, MJ
   David, LR
   Schneider, AM
   Whang, C
   Jennings, DA
   Canty, C
   Parker, D
   White, WL
   Argenta, LC
AF Morykwas, MJ
   David, LR
   Schneider, AM
   Whang, C
   Jennings, DA
   Canty, C
   Parker, D
   White, WL
   Argenta, LC
TI Use of subatmospheric pressure to prevent progression of
   partial-thickness burns in a swine model
SO JOURNAL OF BURN CARE & REHABILITATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; INHIBITION; INJURY
AB The poorly understood, complex series of events that follows thermal injury frequently results in progressive loss of tissue. The concept of reversing this distinctive series of events has focused on the zone of stasis. Tissues in the zone of stasis that surround burn injuries usually die over a period of 48 to 72 hours postinjury, resulting in a more severe injury. Application of a controlled subatmospheric pressure (125 mm Hg) in an artificially closed space to partial-thickness burns in pigs significantly decreased the maximum depth of cellular death under the burn when the pressure was applied within 12 hours after burn creation (depth of control burns = 0.885 +/- 0.115 mm; subatmospheric pressure treated burns (0-hour delay) = 0.095 +/- 0.025 mm). A decrease in the depth of cell death was noted when subatmospheric pressure was applied for as little as 6 hours. In summary, the application of the negative pressure to partial-thickness burn injuries prevented progression of the wound to a deeper injury in this experimental pig model. A 12-hour working window exists between injury and treatment with reduced pressure, with an application time of as Little as 6 hours for successful prevention of injury progression. This technique may represent a new, inexpensive, 'low tech' method for the treatment of partial-thickness burn injuries.
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
   Wake Forest Univ, Sch Med, Dept Pathol, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest University
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
OI Morykwas, Michael/0009-0001-5547-5172
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 25
TC 102
Z9 123
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0273-8481
J9 J BURN CARE REHABIL
JI J. Burn Care Rehabil.
PD JAN-FEB
PY 1999
VL 20
IS 1
BP 15
EP 21
DI 10.1097/00004630-199901001-00003
PN 1
PG 7
WC Emergency Medicine; Rehabilitation; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Rehabilitation; Surgery
GA 161BH
UT WOS:000078267700003
PM 9934631
DA 2026-07-24
ER
PT J
AU Meara, JG
   Guo, LF
   Smith, JD
   Pribaz, JJ
   Breuing, KH
   Orgill, DP
AF Meara, JG
   Guo, LF
   Smith, JD
   Pribaz, JJ
   Breuing, KH
   Orgill, DP
TI Vacuum-assisted closure in the treatment of degloving injuries
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
ID NEGATIVE-PRESSURE; WOUND CONTROL; SKIN-GRAFTS
AB Degloving injuries range from the occult, easily missed injury to obvious massive tissue damage. The serious nature of these wounds is exacerbated by mismanagement. It is generally accepted that the degloved tissue should be excised, defatted, fenestrated, and reapplied as a full-thickness skin graft. Dressings are required that provide gentle, evenly distributed pressure and avoid shear stress to the newly grafted skin. Numerous types of dressings have been devised but all are cumbersome and time-consuming. We have found the Vacuum-Assisted Closure device to be a rapid, effective, and easy-to-use alternative to traditional methods. The authors examine their experience using a vacuum-assisted closure device to treat nine degloving injuries in 5 patients and discuss the important aspects in using this technique.
C1 Brigham & Womens Hosp, Div Plast & Reconstruct Surg, Boston, MA 02119 USA.
   Yale Univ, Sch Med, New Haven, CT USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Yale University
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast & Reconstruct Surg, 75 Francis St, Boston, MA 02119 USA.
RI Orgill, Dennis/H-7596-2019
OI Meara, John G/0000-0003-4369-3209; Guo, Lifei/0000-0003-2019-0086
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   COHEN SR, 1990, PLAST RECONSTR SURG, V86, P780, DOI 10.1097/00006534-199010000-00034
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   NAKAYAMA Y, 1990, PLAST RECONSTR SURG, V86, P1216, DOI 10.1097/00006534-199012000-00031
NR 10
TC 60
Z9 79
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 1999
VL 42
IS 6
BP 589
EP 594
DI 10.1097/00000637-199906000-00002
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 203VE
UT WOS:000080727900002
PM 10382793
DA 2026-07-24
ER
PT J
AU Morykwas, MJ
   Kennedy, A
   Argenta, JP
   Argenta, LC
AF Morykwas, MJ
   Kennedy, A
   Argenta, JP
   Argenta, LC
TI Use of subatmospheric pressure to prevent doxorubicin extravasation
   ulcers in a swine model
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE doxorubicin; extravasation; vacuum; swine model; wound healing
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; SKIN ULCERS; ADRIAMYCIN;
   NECROSIS; INJURIES; CELLS; DMSO; RAT; PIG
AB Application of subatmospheric pressure to sites injected with doxorubicin prevented ulcer formation in treated sites (0 ulcers/16 sites) compared to control wounds (10 ulcers/16 sites) in a pig model.
   Background and Objectives: Extravasation of doxorubicin hydrochloride (Adriamycin) frequently causes chronic ulcers, which usually progress and expose underlying structures such as tendons and bone. The exact mechanism of action that causes cell death and the chronic ulcers is unknown.
   Methods: Eight sites were injected intradermally with doxorubicin on each of 4 pigs. Four sites on each animal served as untreated controls. The remaining four sites were exposed to 125 mm Hg subatmospheric pressure applied 1 h after injection. The sites were observed on a three times per week schedule. Sites that did not develop ulcers were re-injected up to a total of four injections. The animals were observed for 5 weeks.
   Results: Ten of sixteen control sites developed ulcers. No subatmospheric pressure treated sites developed ulcers. The incidence of ulcer formation was significantly less for treated wounds compared to control wounds at P < 0.001 by Fisher's exact test.
   Conclusions: This physical modality appears to successfully prevent ulcer formation after doxorubicin injection. (C) 1999 Wiley-Liss, Inc.
C1 Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
OI Morykwas, Michael/0009-0001-5547-5172
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NR 25
TC 26
Z9 34
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 0022-4790
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD SEP
PY 1999
VL 72
IS 1
BP 14
EP 17
DI 10.1002/(SICI)1096-9098(199909)72:1<14::AID-JSO4>3.0.CO;2-3
PG 4
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 237FC
UT WOS:000082643800004
PM 10477870
OA Bronze
DA 2026-07-24
ER
PT J
AU Greer, SE
   Longaker, MT
   Margiotta, M
   Mathews, AJ
   Kasabian, A
AF Greer, SE
   Longaker, MT
   Margiotta, M
   Mathews, AJ
   Kasabian, A
TI The use of subatmospheric pressure dressing for the coverage of radial
   forearm free flap donor-site exposed tendon complications
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT Meeting of the International-Society-of-Plastic-Reconstructive-Surgeons
CY JUN   22, 1999
CL LOS ANGELES, CALIFORNIA
SP Int Soc Plast Reconstruct Surgeons
AB Since its description in China in 1978, the radial forearm free flap has become a workhorse for the reconstructive surgeon. However, the flap has known disadvantages in complications of the wrist donor site. Skin graft breakdown with exposure of the flexor tendons of the wrist is the most common. The authors describe in a patient series a new treatment for this complication. They used subatmospheric pressure dressing to stimulate granulation tissue coverage of the tendon and to facilitate epithelialization. As many as one third of all patients undergoing radial forearm free flaps develop exposed tendon complications and may benefit from Vacuum Assisted Closure (VAC) therapy.
C1 NYU, Med Ctr, Inst Reconstruct Plast Surg, New York, NY 10016 USA.
C3 New York University
RP Greer, SE (通讯作者)，300 E 34th St,Apartment 9F, New York, NY 10016 USA.
OI Longaker, Michael/0000-0003-1430-8914
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BARDSLEY AF, 1990, PLAST RECONSTR SURG, V86, P287, DOI 10.1097/00006534-199008000-00014
   EVANS GRD, 1994, AM J SURG, V168, P446, DOI 10.1016/S0002-9610(05)80096-0
   Lutz BS, 1999, PLAST RECONSTR SURG, V103, P132, DOI 10.1097/00006534-199901000-00021
   SONG RY, 1982, CLIN PLAST SURG, V9, P21
   SWANSON E, 1990, PLAST RECONSTR SURG, V85, P258, DOI 10.1097/00006534-199002000-00016
NR 6
TC 25
Z9 36
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD NOV
PY 1999
VL 43
IS 5
BP 551
EP 554
DI 10.1097/00000637-199911000-00016
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 253LD
UT WOS:000083557300018
PM 10560875
DA 2026-07-24
ER
PT J
AU DeFranzo, AJ
   Marks, MW
   Argenta, LC
   Genecov, DG
AF DeFranzo, AJ
   Marks, MW
   Argenta, LC
   Genecov, DG
TI Vacuum-assisted closure for the treatment of degloving injuries
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Scientific Meeting of the
   American-Society-of-Plastic-and-Reconstructive-Surgeons/Plastic-Surgery-
   Education-Foundation/American-Society-of-Maxillofacial-Surgeons
CY OCT 04-07, 1998
CL BOSTON, MASSACHUSETTS
SP Amer Soc Plast & Reconstruct Surgeons, Plast Surg Educ Fdn, Amer Soc Maxillofacial Surgeons
ID WOUND CONTROL; SKIN-GRAFTS
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
   Int Craniofacial Inst, Cleft Lip & Palate Treatment Ctr, Dallas, TX USA.
C3 Wake Forest University
RP DeFranzo, AJ (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
NR 4
TC 69
Z9 98
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 1999
VL 104
IS 7
BP 2145
EP 2148
DI 10.1097/00006534-199912000-00031
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 258TH
UT WOS:000083854900032
PM 11149782
DA 2026-07-24
ER
PT J
AU Obdeijn, MC
   de Lange, MY
   Lichtendahl, DHE
   de Boer, WJ
AF Obdeijn, MC
   de Lange, MY
   Lichtendahl, DHE
   de Boer, WJ
TI Vacuum-assisted closure in the treatment of poststernotomy mediastinitis
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID WOUND CONTROL
AB A new technique using vacuum-assist-ed closure was successfully applied in 3 patients with poststernotomy mediastinitis. After surgical debridement, this vacuum-assisted closure technique has made it possible to avoid the need for secondary surgical closure (including direct secondary surgical closure and secondary surgical closure by use of vascularized muscle flaps). A healed stable sternotomy wound can be achieved using this new technique. (C) 1999 by The Society of Thoracic Surgeons.
C1 Univ Groningen Hosp, Dept Cardiothorac Surg, NL-9700 RB Groningen, Netherlands.
   Univ Groningen Hosp, Dept Plast & Reconstruct Surg, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen; University of Groningen
RP de Boer, WJ (通讯作者)，Univ Groningen Hosp, Dept Cardiothorac Surg, POB 30-001, NL-9700 RB Groningen, Netherlands.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
NR 5
TC 125
Z9 150
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD DEC
PY 1999
VL 68
IS 6
BP 2358
EP 2360
DI 10.1016/S0003-4975(99)01159-5
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 270XY
UT WOS:000084563500099
PM 10617044
DA 2026-07-24
ER
PT J
AU Tang, ATM
   Ohri, SK
   Haw, MP
AF Tang, ATM
   Ohri, SK
   Haw, MP
TI Novel application of vacuum assisted closure technique to the treatment
   of sternotomy wound infection
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE negative pressure therapy; sternal dehiscence; mediastinitis; treatment
AB Infection of the sternotomy wound is a potentially devastating and sometimes lethal complication following cardiac surgery. Established treatment may involve a combination of debridement, packing, delayed closure, plastic reconstruction, re-wiring and irrigation dependent on the severity of infection. Vacuum assisted closure, originally adopted for the treatment of non-healing wounds, has recently gained popularity among various surgical specialities in managing complex wound infection. Here we describe this novel technique of managing postoperative sternal wound infection. (C) 2000 Elsevier Science B.V. All rights reserved.
C1 Southampton Gen Hosp, Wessex Reg Thorac & Cardiac Unit, Dept Cardiac Surg, Southampton SO16 6YD, Hants, England.
C3 University of Southampton
RP Tang, ATM (通讯作者)，Southampton Gen Hosp, Wessex Reg Thorac & Cardiac Unit, Dept Cardiac Surg, Tremona Rd, Southampton SO16 6YD, Hants, England.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Davydov Iu A, 1994, Khirurgiia (Mosk), P7
   Davydov Iu A, 1992, Khirurgiia (Mosk), P21
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Raudat CW, 1997, AM SURGEON, V63, P238
NR 6
TC 87
Z9 102
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1010-7940
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD APR
PY 2000
VL 17
IS 4
BP 482
EP 484
DI 10.1016/S1010-7940(00)00349-3
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 311WT
UT WOS:000086909700037
PM 10773574
OA Bronze
DA 2026-07-24
ER
PT J
AU de Lange, MY
   Schasfoort, RA
   Obdeijn, MC
   van der Werff, JFA
   Nicolai, JPA
AF de Lange, MY
   Schasfoort, RA
   Obdeijn, MC
   van der Werff, JFA
   Nicolai, JPA
TI Vacuum-assisted closure: indications and clinical experience
SO EUROPEAN JOURNAL OF PLASTIC SURGERY
LA English
DT Article
DE wound healing; vacuum therapy
ID WOUND CONTROL
AB The use of subatmospheric pressure to promote wound healing has gradually found support in the past few years. The vacuum-assisted closure system uses a pump providing a continuous negative pressure of preferably 125 mmHg, which is distributed over the wound surface by an airtight covered foam. The exact mechanisms of vacuum therapy are not yet understood, but clinically soft tissue defects seem to heal faster when subatmospheric pressure is applied. Our experience with the first 100 patients with soft tissue defects of different origin that were treated with vacuum therapy is presented. In 29 patients, the wounds healed without further surgical intervention, 53 patients underwent secondary wound closure and 11 patients required more than one procedure. Seven patients died due to their underlying disease. Few complications were seen. Vacuum sealing is a new therapeutic concept in wound healing which can precede and sometimes replace surgical wound closure.
C1 Acad Ziekenhuis Groningen, Dept Plast Surg, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen
RP van der Werff, JFA (通讯作者)，Acad Ziekenhuis Groningen, Dept Plast Surg, Postbus 30-001, NL-9700 RB Groningen, Netherlands.
EM j.f.a.van.der.werff@chir.azg.nl
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P, 1998, BRIT J PLAST SURG, V51, P79, DOI 10.1016/S0007-1226(98)80142-2
   FIELD CK, 1994, AM J SURG, V167, pS2, DOI 10.1016/0002-9610(94)90002-7
   Fleischmann W, 1997, UNFALLCHIRURG, V100, P301, DOI 10.1007/s001130050123
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Masters J, 1998, BRIT J PLAST SURG, V51, P267, DOI 10.1016/S0007-1226(98)80028-3
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
NR 10
TC 22
Z9 65
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-343X
EI 1435-0130
J9 EUR J PLAST SURG
JI Eur. J. Plast. Surg.
PD MAY
PY 2000
VL 23
IS 4
BP 178
EP 182
DI 10.1007/s002380050244
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 321GE
UT WOS:000087447100006
DA 2026-07-24
ER
PT J
AU Joseph, E
   Hamori, CA
   Bergman, S
   Roaf, E
   Swann, NF
   Anastasi, GW
AF Joseph, E
   Hamori, CA
   Bergman, S
   Roaf, E
   Swann, NF
   Anastasi, GW
TI A prospective randomized trial of vacuum-assisted closure versus
   standard therapy of chronic nonhealing wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID DRESSINGS
AB Chronic, open, nonhealing wounds pose a continual challenge in medicine. Our objective was to evaluate vacuum-assisted closure (VAC)* therapy's ability to improve the healing rare of chronic wounds compared to the traditional saline-wet-to-moist (WM) dressings. Twenty-four patients with 36 chronic, nonhealing wounds were enrolled in the study after obtaining proper consent. Subjects were randomized to the VAC group or the control group. Biopsies and wound measurements were obtained by blinded independent wound evaluators. The most significant difference was the change in depth of 66 percent for VAC compared to 20 percent for WM (p<.00001). Histologically, the groups exhibited different characteristics. In the WM group, 81 percent (n=13) displayed inflammation and fibrosis. The chief characteristic of the VAC group was granulation tissue formation in 64 percent (n=9) of those wounds. The VAC system should be used to obtain wound closure, especially of chronic nonhealing wounds with great depth, rather than the traditional saline WM dressings.
C1 Med Coll Ohio, Dept Plast Surg, Toledo, OH 43615 USA.
RP Joseph, E (通讯作者)，Med Coll Ohio, Dept Plast Surg, 626 Pine Valley Lane,203, Toledo, OH 43615 USA.
CR ALM A, 1989, ACTA DERM-VENEREOL S, V149, P1
   ALVEREZ O, 1983, J SURG RES, V35, P142
   [Anonymous], 1989, WOUNDS
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   COLWELL JC, 1992, DECUBITUS, V6, P28
   GORSE GJ, 1987, ARCH DERMATOL, V123, P766, DOI 10.1001/archderm.123.6.766
   HIBBS P, 1989, DECUBITUS, V2, P32
   LAZARUS GS, 1994, ARCH DERMATOL, V130, P489, DOI 10.1001/archderm.130.4.489
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Oleske D M, 1986, J Enterostomal Ther, V13, P90
   PORIES WJ, 1966, SURGERY, V59, P821
   Robson MC, 1999, WOUND REPAIR REGEN, V7, P90, DOI 10.1046/j.1524-475X.1999.00090.x
   XAKELLIS GC, 1992, ARCH PHYS MED REHAB, V73, P463
NR 13
TC 251
Z9 312
U1 0
U2 14
PU HEALTH MANAGEMENT PUBLICATIONSINC
PI WAYNE
PA 950 WEST VALLEY RD, STE 2800, WAYNE, PA 19087 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY-JUN
PY 2000
VL 12
IS 3
BP 60
EP 67
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 325LN
UT WOS:000087677200006
DA 2026-07-24
ER
PT J
AU Mooney, JF
   Argenta, LC
   Marks, MW
   Morykwas, MJ
   DeFranzo, AJ
AF Mooney, JF
   Argenta, LC
   Marks, MW
   Morykwas, MJ
   DeFranzo, AJ
TI Treatment of soft tissue defects in pediatric patients using the
   VACTM system
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL
AB Twenty-seven consecutive pediatric patients presenting to the orthopaedic surgery or plastic surgery services were reviewed after completion of wound care with the Vacuum Assisted Closure (V.A.C.(TM)) system. Each patient presented with complex soft tissue wounds requiring coverage procedures. Patients with acute wounds and wounds present after nonsuccessful attempts at surgical closure (dehisced incisions and failed flaps) were treated. All soft tissue defects healed without extensive coverage procedures using the V.A.C.(TM) system. In the majority of patients, use of the V.A.C.(TM) system produced a profuse bed of granulation tissue over all exposed bone, tendon, joint, and/or hardware, which could be covered with split thickness skin graft. Other patients were treated successfully with delayed primary closure, local flap advancement (one patient underwent a pedicled cross-leg flap), or by secondary intention. Use of the V.A.C.(TM) device is valuable in increasing the rate of granulation tissue formation and healing of extensive soft tissue injuries in pediatric patients. This vacuum system aids in the debridement of necrotic tissue and local soluble inflammatory mediators that may inhibit the proliferation of granulation tissue. These improvements in the local wound environment seem to accelerate wound healing compared with traditional methods. Before the development of the V.A.C.(TM) system, a minimum of nine patients within this group would have required free tissue transfer to obtain adequate coverage. The V.A.C.(TM) device seems to permit earlier coverage with local tissue or split-thickness skin grafting techniques, thereby decreasing the need for extensive microvascular tissue transfers in pediatric patients.
C1 Wayne State Univ, Sch Med, Dept Pediat Orthopaed Surg, Detroit, MI USA.
   Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC USA.
C3 Wayne State University; Wake Forest University
RP Mooney, JF (通讯作者)，Childrens Hosp Michigan, Dept Pediat Orthopaed Surg, 3901 Beaubien Blvd, Detroit, MI 48201 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bucalo Brian, 1993, Wound Repair and Regeneration, V1, P181, DOI 10.1046/j.1524-475X.1993.10308.x
   Falanga Vincent, 1992, Journal of Dermatology (Tokyo), V19, P667
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   WYSOCKI AB, 1993, J INVEST DERMATOL, V101, P64, DOI 10.1111/1523-1747.ep12359590
   WYSOCKI AB, 1990, LAB INVEST, V63, P825
NR 7
TC 83
Z9 90
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-921X
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD JUL
PY 2000
IS 376
BP 26
EP 31
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 329PL
UT WOS:000087915800006
DA 2026-07-24
ER
PT J
AU Avery, C
   Pereira, J
   Moody, A
   Whitworth, I
AF Avery, C
   Pereira, J
   Moody, A
   Whitworth, I
TI Clinical experience with the negative pressure wound dressing
SO BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS
AB Between 1997 and 1999, more than 300 patients have been treated using negative pressure wound dressings. The technique has been used successfully to prepare various acute, chronic or infected wounds to accept a skin graft or flap, and to promote graft take at difficult donor sites. The advantages include rapid healing by secondary intention, reduced time to skin grafting, an increase in the rate of graft take and a reduction in donor site complications. The dressing can be applied quickly and easily and there have been no serious complications.
C1 Queen Victoria Hosp, Dept Maxillofacial Surg, E Grinstead, England.
   Queen Victoria Hosp, Dept Plast Surg, E Grinstead, England.
RP Avery, C (通讯作者)，Queen Victoria Hosp, Dept Maxillofacial Surg, E Grinstead, England.
RI /AAI-1364-2019; moody, alan/M-9258-2019
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Johnson PA, 1998, BRIT J ORAL MAX SURG, V36, P141, DOI 10.1016/S0266-4356(98)90184-X
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
NR 5
TC 19
Z9 30
U1 0
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0266-4356
J9 BRIT J ORAL MAX SURG
JI Br. J. Oral Maxillofac. Surg.
PD AUG
PY 2000
VL 38
IS 4
BP 343
EP 345
DI 10.1054/bjom.1999.0453
PG 3
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 344BD
UT WOS:000088737000021
PM 10922165
DA 2026-07-24
ER
PT J
AU Deva, AK
   Buckland, CH
   Fisher, E
   Liew, SCC
   Merten, S
   McGlynn, V
   Gianoutsos, MP
   Baldwin, MAR
   Lendvay, PG
AF Deva, AK
   Buckland, CH
   Fisher, E
   Liew, SCC
   Merten, S
   McGlynn, V
   Gianoutsos, MP
   Baldwin, MAR
   Lendvay, PG
TI Topical negative pressure in wound management
SO MEDICAL JOURNAL OF AUSTRALIA
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Objective: To investigate the role of topical negative pressure (TNP) therapy in the management of difficult wounds.
   Design: Prospective consecutive patient series.
   Patients and setting: 30 patients referred to our tertiary plastic and reconstructive surgical service with wounds deemed unsuitable for reconstructive surgery were treated between November 1997 and the end of December 1998. The mean pretreatment duration of the wounds was 418 days (range, 8-1650 days). All wounds were at least Grade III pressure sores.
   Intervention: Topical negative pressure therapy (TNP) using the VAC device (KCI Medical, San Antonio, USA). Suction (75-125 mmHg) was continuous for the first 48 hours, then intermittent (2 min on, 5 min off).
   Main outcome measures: Achievement of wound healing endpoints: (1) complete healing of the wound; (2) obliteration of the wound cavity to allow surface dressings; or (3) closure of the wound by suture or skin graft.
   Results: TNP was successful in 26 out of 30 patients with mean therapy time of 35 days (range, 3-124 days). Healing was more rapid in acute (less than six weeks old) wounds. A reduction in the number of bacterial species and colonies was also observed during therapy.
   Conclusion: TNP can, in some circumstances, promote rapid secondary wound healing. A further randomised trial of TNP versus more traditional wound management modalities is justified.
C1 Prince Wales Hosp, Dept Plast & Reconstruct Surg, Sydney, NSW, Australia.
C3 University of New South Wales Sydney; Prince of Wales Hospital (POWH)
RP Deva, AK (通讯作者)，6 Darghan St, Glebe, NSW 2037, Australia.
RI ; Merten, Sonja/KBQ-1858-2024
OI Deva, Anand/0000-0002-0314-7177; 
CR Altman D., 1990, PRACTICAL STAT MED R, V1st, P365, DOI [10.1201/9780429258589/practical-statistics-medical-research-douglas-altman, DOI 10.1201/9780429258589/PRACTICAL-STATISTICS-MEDICAL-RESEARCH-DOUGLAS-ALTMAN]
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P E, 1999, J Wound Care, V8, P79
   Baxandall T, 1997, Elder Care, V9, P22
   Deva A K, 1997, J Wound Care, V6, P311
   FLEISCHMANN W, 1995, EUR J ORTHOPAEDICS S, V38, P553
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Miasnikov A D, 1994, Klin Khir, P13
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   *NAT PRESS ULC ADV, 1998, SEL READ PLAST SURG, V8, P1
   Strover AE, 1997, J ROY COLL SURG EDIN, V42, P119
NR 13
TC 51
Z9 68
U1 0
U2 5
PU AUSTRALASIAN MED PUBL CO LTD
PI SYDNEY
PA LEVEL 1, 76 BERRY ST, SYDNEY, NSW 2060, AUSTRALIA
SN 0025-729X
J9 MED J AUSTRALIA
JI Med. J. Aust.
PD AUG 7
PY 2000
VL 173
IS 3
BP 128
EP 131
DI 10.5694/j.1326-5377.2000.tb125564.x
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 344RV
UT WOS:000088773400006
PM 10979377
DA 2026-07-24
ER
PT J
AU Greer, SE
   Adelman, M
   Kasabian, A
   Galiano, RD
   Scott, R
   Longaker, MT
AF Greer, SE
   Adelman, M
   Kasabian, A
   Galiano, RD
   Scott, R
   Longaker, MT
TI The use of subatmospheric pressure dressing therapy to close
   lymphocutaneous fistulas of the groin
SO BRITISH JOURNAL OF PLASTIC SURGERY
LA English
DT Article
DE lymphorrhea; subatmospheric pressure dressing therapy; lymphocutaneous
   fistulas; vacuum assisted closure
ID VACUUM-ASSISTED CLOSURE; ARTERIAL RECONSTRUCTION; WOUND CONTROL;
   FREE-FLAP; COMPLICATIONS; LYMPHORRHEA
AB Groin lymphorrhea is an uncommon but serious complication of vascular and cardiac surgery as well as interventional procedures that cannulate the femoral vessels. Treatment options are somewhat controversial. For lymphocutaneous fistulas, a commonly used current modality is early surgical ligation with the assistance of blue-dye staining of the lymphatic anatomy. The purpose of this case series is to give the first description of a new, less invasive, approach using subatmospheric pressure dressing therapy for the treatment of the challenging problem of lymphocutaneous fistulas of the groin. (C) 2000 The British Association of Plastic Surgeons.
C1 NYU Med Ctr, Inst Reconstruct Plast Surg, New York, NY 10016 USA.
   NYU Med Ctr, Div Vasc Surg, New York, NY 10016 USA.
   Presbyterian Med Ctr, Wound Care Clin N Texas, Dallas, TX USA.
C3 New York University; New York University
RP Greer, SE (通讯作者)，300 E 34th St,9th Floor, New York, NY 10016 USA.
OI Longaker, Michael/0000-0003-1430-8914; Adelman, Mark/0000-0001-9276-6131
CR AlSalman MMS, 1997, INT SURG, V82, P60
   [Anonymous], WOUND REPAIR REGENER
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Greer S, 1998, ANN PLAS SURG, V41, P687, DOI 10.1097/00000637-199812000-00022
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
   Greer SE, 1999, ANN PLAS SURG, V43, P551, DOI 10.1097/00000637-199911000-00016
   GREER SE, IN PRESS ANN THORACI
   Kent RC, 1996, SURGERY, V119, P378
   KHALIL IM, 1987, J VASC SURG, V6, P93, DOI 10.1067/mva.1987.avs0060093
   KWAAN JHM, 1979, ARCH SURG-CHICAGO, V114, P1416
   Mirazimov B M, 1966, Ortop Travmatol Protez, V27, P19
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   ROBERTS JR, 1993, AM J SURG, V165, P341, DOI 10.1016/S0002-9610(05)80839-6
   SETHI GK, 1978, J CARDIOVASC SURG, V19, P155
   SKUDDER PA, 1987, J CARDIOVASC SURG, V28, P460
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   TYNDALL SH, 1994, J VASC SURG, V19, P858, DOI 10.1016/S0741-5214(94)70011-7
   ZAMIEROWSKI, 1990, WOUND DRESSING TREAT
NR 22
TC 32
Z9 668
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0007-1226
J9 BRIT J PLAST SURG
JI Br. J. Plast. Surg.
PD SEP
PY 2000
VL 53
IS 6
BP 484
EP 487
DI 10.1054/bjps.2000.3360
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 345WC
UT WOS:000088837300006
PM 10927677
OA Bronze
DA 2026-07-24
ER
PT J
AU Avery, C
   Pereira, J
   Moody, A
   Gargiulo, M
   Whitworth, I
AF Avery, C
   Pereira, J
   Moody, A
   Gargiulo, M
   Whitworth, I
TI Negative pressure wound dressing of the radial forearm donor site
SO INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
DE wound dressing; negative pressure; radial donor site
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS; MORBIDITY; FLAP
AB Donor site complications of the radial forearm are a significant cause of post-operative morbidity. 15 patients had radial forearm free tissue donor sites treated with split skin grafts and a negative pressure dressing. All grafts showed 100% take at 5 days. The advantages of this technique include rapid healing at an unfavourable graft recipient site, increased graft take and decreased donor site complications. This method is ideally suited for the management of large defects. The dressing can be quickly and easily applied and there have been no significant complications.
C1 Queen Victoria Hosp, Dept Maxillofacial Surg, E Grinstead RH19 3DZ, W Sussex, England.
   Queen Victoria Hosp, Dept Plast Surg, E Grinstead RH19 3DZ, W Sussex, England.
RP Avery, C (通讯作者)，Queen Victoria Hosp, Dept Maxillofacial Surg, Holtye Rd, E Grinstead RH19 3DZ, W Sussex, England.
RI /AAI-1364-2019; moody, alan/M-9258-2019
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BARDSLEY AF, 1990, PLAST RECONSTR SURG, V86, P287, DOI 10.1097/00006534-199008000-00014
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Johnson PA, 1998, BRIT J ORAL MAX SURG, V36, P141, DOI 10.1016/S0266-4356(98)90184-X
   Lutz BS, 1999, PLAST RECONSTR SURG, V103, P132, DOI 10.1097/00006534-199901000-00021
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Richardson D, 1997, PLAST RECONSTR SURG, V99, P109, DOI 10.1097/00006534-199701000-00017
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
NR 9
TC 39
Z9 46
U1 0
U2 1
PU MUNKSGAARD INT PUBL LTD
PI COPENHAGEN
PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK
SN 0901-5027
J9 INT J ORAL MAX SURG
JI Int. J. Oral Maxillofac. Surg.
PD JUN
PY 2000
VL 29
IS 3
BP 198
EP 200
DI 10.1016/S0901-5027(00)80092-2
PG 3
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 346AH
UT WOS:000088847600008
PM 10970082
DA 2026-07-24
ER
PT J
AU Scheufler, O
   Peek, A
   Kania, NM
   Exner, K
AF Scheufler, O
   Peek, A
   Kania, NM
   Exner, K
TI Problem-adapted application of vacuum occlusion dressings: case report
   and clinical experience
SO EUROPEAN JOURNAL OF PLASTIC SURGERY
LA English
DT Article
DE vacuum-assisted closure (VAC); wound conditioning; split skin graft
ID NEGATIVE-PRESSURE; ASSISTED CLOSURE; WOUND CONTROL
AB Vacuum-assisted closure (VAC), a technique using subatmospheric pressure dressings, has been widely used for treatment of various chronic and complicated wounds. In addition to the advantages of an occlusive dressing therapy, the VAC therapy has proved effective in evacuating wound fluid, increasing tissue oxygen tension, decreasing bacterial contamination, and stimulating granulation tissue formation. This leads to more rapid reepithelialization of wounds compared to conventional dressings. A two-phase VAC technique to provide enhanced coverage of an ischemic ulcer of the lower leg in a diabetic patient is presented. The refined VAC therapy scheme is described in detail and the results in a further 19 patients with complicated wounds of the lower leg and feet are reported.
C1 Univ Frankfurt, Acad Teaching Hosp, Markus Hosp, Dept Plast Reconstruct & Handsurg,Sch Med, D-60431 Frankfurt, Germany.
C3 Goethe University Frankfurt
RP Scheufler, O (通讯作者)，Univ Frankfurt, Acad Teaching Hosp, Markus Hosp, Dept Plast Reconstruct & Handsurg,Sch Med, Wilhelm Epstein Str 2, D-60431 Frankfurt, Germany.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bauer P, 1998, Handchir Mikrochir Plast Chir, V30, P20
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
NR 7
TC 2
Z9 6
U1 0
U2 3
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0930-343X
J9 EUR J PLAST SURG
JI Eur. J. Plast. Surg.
PD OCT
PY 2000
VL 23
IS 7
BP 386
EP 390
DI 10.1007/s002380000189
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 368YT
UT WOS:000090145600011
DA 2026-07-24
ER
PT J
AU Fabian, TS
   Kaufman, HJ
   Lett, ED
   Thomas, JB
   Rawl, DK
   Lewis, PL
   Summitt, JB
   Merryman, JI
   Schaeffer, D
   Sargent, LA
   Burns, RP
AF Fabian, TS
   Kaufman, HJ
   Lett, ED
   Thomas, JB
   Rawl, DK
   Lewis, PL
   Summitt, JB
   Merryman, JI
   Schaeffer, D
   Sargent, LA
   Burns, RP
TI The evaluation of subatmospheric pressure and hyperbaric oxygen in
   ischemic full-thickness wound healing
SO AMERICAN SURGEON
LA English
DT Article; Proceedings Paper
CT 68th Annual Meeting of the Southeastern-Surgical-Congress
CY FEB 05-08, 2000
CL ORLANDO, FL
SP SE Surg Congress
ID VACUUM-ASSISTED CLOSURE; INSPIRED OXYGEN; ANGIOGENESIS; SURVIVAL;
   THERAPY; TENSION; STRESS; GROWTH; TRIAL
AB We evaluated the efficacy of subatmospheric pressure and hyperbaric oxygen (HBO) as adjuncts in the treatment of hypoxic full-thickness wounds in a rabbit model. We hypothesized that subatmospheric pressure and HBO independently are effective in improving wound healing in the ischemic wound model and that when they are used in combination there is an increased positive effect on wound healing. Using a standard ischemic wound model four full-thickness wounds were created on each ear of 41 male New Zealand white rabbits (N = 82 ears). On each rabbit one ear was dressed with the vacuum-assisted closure (VAC) device and connected to suction; the other was dressed identically without the suction and suction tubing. Twenty rabbits were treated with HBO daily for 10 days at 2.0 atmospheres absolute for 90 minutes plus descent and ascent times. Necropsy on all rabbits was performed on postoperative day 10. Four ischemic wound treatment groups were evaluated: Group 1 (N = 21) VAC dressing alone; Group 2 (N = 20) VAC dressing plus HBO; Group 3 (N = 21) VAC dressing to suction alone; and Group 4 (N = 20) VAC dressing to suction and HBO. Using light microscopy a veterinary pathologist blinded to treatment groups quantified peak granulation tissue, granulation tissue gap, and epithelialization tissue gap. Data were analyzed by analysis of variance with significance indicated by P < 0.05. Statistical significance was found in a comparison of VAC dressing to suction and VAC dressing alone for peak granulation tissue and granulation tissue gap both with and without use of HBO. VAC device use appears to increase the rate of healing in a rabbit ischemic wound model. HBO therapy did not significantly affect the rate of healing in this model.
C1 Univ Tennessee, Coll Med, Dept Surg, Chattanooga Unit, Chattanooga, TN 37403 USA.
   Univ Tennessee, Coll Med, Dept Plast Surg, Chattanooga Unit, Chattanooga, TN 37403 USA.
   Univ Tennessee, Coll Med, Knoxville, TN USA.
   Washington Univ, Sch Med, Div Plast & Reconstruct Surg, St Louis, MO USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center; University of Tennessee System; University of Tennessee Health
   Science Center; University of Tennessee System; University of Tennessee
   Health Science Center; Washington University (WUSTL)
RP Burns, RP (通讯作者)，Univ Tennessee, Coll Med, Dept Surg, Chattanooga Unit, 979 E 3rd St,Suite 401, Chattanooga, TN 37403 USA.
CR AHN ST, 1990, ANN PLAS SURG, V24, P17, DOI 10.1097/00000637-199001000-00004
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NR 45
TC 101
Z9 152
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD DEC
PY 2000
VL 66
IS 12
BP 1136
EP 1143
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 383HE
UT WOS:000165876400016
PM 11149585
DA 2026-07-24
ER
PT J
AU Bonnamy, C
   Hamel, F
   Leporrier, J
   Fouques, Y
   Viquesnel, G
   Le Roux, Y
AF Bonnamy, C
   Hamel, F
   Leporrier, J
   Fouques, Y
   Viquesnel, G
   Le Roux, Y
TI Vacuum-assisted closure in the treatment of a perineal gangrene extended
   to the abdominal wall.
SO ANNALES DE CHIRURGIE
LA French
DT Article
DE perineal gangrene; vacuum-assisted closure
AB The vacuum-assisted closure (VAC) system is used for the treatment of complicated wounds and large tissular dehiscences. The study aim was to report a case of perineal gangrene extended to the abdominal wall in a 53-year old woman. After several extensive surgical debridments, using of the VAC was followed by a good and rapid healing of the wound. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
C1 CHU Caen, Dept Chirurg Gen & Digest, F-14033 Caen, France.
   CHU Caen, Dept Anesthesie Reanimat, F-14033 Caen, France.
C3 CHU de Caen NORMANDIE; Universite de Caen Normandie; Universite de Caen
   Normandie; CHU de Caen NORMANDIE
RP Bonnamy, C (通讯作者)，CHU Caen, Dept Chirurg Gen & Digest, Ave Cote Nacre, F-14033 Caen, France.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Asoklis S, 1996, ANN CHIR, V50, P181
   FABIANI P, 1998, ENCYCL MED CHIR, P1
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Lago J, 2000, ANN CHIR, V125, P299, DOI 10.1016/S0001-4001(00)00134-3
   Meara JG, 1999, ANN PLAS SURG, V42, P589, DOI 10.1097/00000637-199906000-00002
   TEOT L, 1996, P 6 EUR C ADV WOUND
NR 7
TC 12
Z9 19
U1 0
U2 2
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0003-3944
J9 ANN CHIR
JI Ann. Chir.
PD DEC
PY 2000
VL 125
IS 10
BP 982
EP 984
DI 10.1016/S0003-3944(00)00411-9
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 387PT
UT WOS:000166131500010
PM 11195929
DA 2026-07-24
ER
PT J
AU Elwood, ET
   Bolitho, DG
AF Elwood, ET
   Bolitho, DG
TI Negative-pressure dressings in the treatment of hidradenitis suppurativa
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Negative-pressure dressings have been used in the treatment of a variety of open wounds, and as a bolster for skin grafts. The benefits of these dressings include increased oxygen tension in the wound, decreased bacterial counts, increased granulation formation, and the prevention of shear force on wounds. Also, by virtue of the diminished need for daily dressing changes, there are the additional advantages of enhancing patient comfort, decreasing nursing work, and diminished cost of wound care. Hidradenitis suppurativa (HS) is a chronic infection of the apocrine sweat glands. Treatment options range from oral isotretinoin to radical excision. Wound closure may be achieved by secondary intention, skin grafting, or flap closure, Complications may still arise and include disease progression and squamous cell carcinoma. Radical excision yields the best results in terms of disease eradication. The authors describe using the negative-pressure dressing in two cases of bilateral axillary HS to secure skin grafts firmly to the wound bed after radical excision of all involved tissues. Patient comfort and acceptance was high, and skin graft take was excellent. The dressings themselves are simple to apply and are highly effective.
C1 Emory Univ, Sch Med, Dept Surg, Div Plast Surg, Atlanta, GA 30322 USA.
C3 Emory University
RP Elwood, ET (通讯作者)，1365 Clifton R NE,Bldg B,Suite 2100, Atlanta, GA 30322 USA.
CR Amarante J, 1996, AESTHET PLAST SURG, V20, P443
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 15
TC 34
Z9 62
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JAN
PY 2001
VL 46
IS 1
BP 49
EP 51
DI 10.1097/00000637-200101000-00010
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 391PR
UT WOS:000166364800010
PM 11192034
DA 2026-07-24
ER
PT J
AU Avery, CME
   Pereira, J
   Brown, AE
AF Avery, CME
   Pereira, J
   Brown, AE
TI Suprafascial dissection of the radial forearm flap and donor site
   morbidity
SO INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
DE radial flap; donor site; suprafascial dissection; negative pressure
   wound dressing
ID VACUUM-ASSISTED CLOSURE; FULL-THICKNESS SKIN; CLINICAL-EXPERIENCE; WOUND
   CONTROL; GRAFT
AB A cutaneous free radial forearm flap was harvested from 25 patients using a suprafascial dissection technique. The donor site was managed with either a full or split thickness skin graft and a negative pressure wound dressing. The incidence of initial complete graft take was 96% at day 5 and 100% by 1 month. There was 100% early and complete graft take in the full thickness group but one area of partial loss in the split thickness group. This area of graft loss represented less than 0.5% of the total grafted area in this series. The mean time to wound healing was 14 days. There were no cases of tendon exposure or delayed healing. The suprafascial dissection creates a superior graft recipient bed. When combined with the negative pressure wound dressing technique it ensured early and complete graft take.
C1 Queen Victoria Hosp, Dept Maxillofacial Surg, E Grinstead RH19 3DZ, W Sussex, England.
   Queen Victoria Hosp, Dept Plast Surg, E Grinstead RH19 3DZ, W Sussex, England.
RP Avery, CME (通讯作者)，Queen Victoria Hosp, Dept Maxillofacial Surg, Holtye Rd, E Grinstead RH19 3DZ, W Sussex, England.
RI /AAI-1364-2019
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Avery C, 2000, INT J ORAL MAX SURG, V29, P198, DOI 10.1016/S0901-5027(00)80092-2
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   Chang SCN, 1996, MICROSURG, V17, P136
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   Lutz BS, 1999, PLAST RECONSTR SURG, V103, P132, DOI 10.1097/00006534-199901000-00021
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Richardson D, 1997, PLAST RECONSTR SURG, V99, P109, DOI 10.1097/00006534-199701000-00017
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NR 20
TC 52
Z9 57
U1 0
U2 1
PU MUNKSGAARD INT PUBL LTD
PI COPENHAGEN
PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK
SN 0901-5027
J9 INT J ORAL MAX SURG
JI Int. J. Oral Maxillofac. Surg.
PD FEB
PY 2001
VL 30
IS 1
BP 37
EP 41
DI 10.1054/ijom.2000.0016
PG 5
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 406GR
UT WOS:000167207000006
PM 11289619
DA 2026-07-24
ER
PT J
AU Gilmour, E
   Stewart, DG
AF Gilmour, E
   Stewart, DG
TI Severe recalcitrant pyoderma gangrenosum responding to a combination of
   mycophenolate mofetil with cyclosporin and complicated by a mononeuritis
SO BRITISH JOURNAL OF DERMATOLOGY
LA English
DT Article
DE mononeuritis; mycophenolate mofetil; negative pressure dressing;
   pyoderma gangrenosum
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; TACROLIMUS
AB We describe a 17-year-old boy with severe recalcitrant pyoderma gangrenosum. Healing was achieved with a combination of mycophenolate mofetil and cyclosporin, negative pressure dressings and split-skin grafts. His recovery was complicated by a sciatic nerve palsy, which we believe was caused by direct involvement of the nerve at the level of the sciatic notch.
C1 Univ Hosp Birmingham NHS Trust, Dept Dermatol, Birmingham B29 6JD, W Midlands, England.
RP Gilmour, E (通讯作者)，Univ Hosp Birmingham NHS Trust, Dept Dermatol, Raddlebarn Rd, Birmingham B29 6JD, W Midlands, England.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brunsting LA, 1930, ARCH DERMATOL SYPH, V22, P655, DOI 10.1001/archderm.1930.01440160053009
   Cooley HM, 1996, AUST NZ J MED, V26, P238, DOI 10.1111/j.1445-5994.1996.tb00896.x
   CURLEY RK, 1985, BRIT J DERMATOL, V113, P601, DOI 10.1111/j.1365-2133.1985.tb02385.x
   EPINETTE WW, 1987, J AM ACAD DERMATOL, V17, P962, DOI 10.1016/S0190-9622(87)70285-0
   Hohenleutner U, 1997, LANCET, V350, P1748, DOI 10.1016/S0140-6736(05)63571-4
   Lyon CC, 1999, BRIT J DERMATOL, V140, P562
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nousari HC, 1998, ARCH DERMATOL, V134, P1509, DOI 10.1001/archderm.134.12.1509
   Schuppe HC, 1998, LANCET, V351, P832, DOI 10.1016/S0140-6736(05)78962-5
   1997, DRUG THER B, V35, P38
NR 11
TC 25
Z9 27
U1 0
U2 0
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0007-0963
J9 BRIT J DERMATOL
JI Br. J. Dermatol.
PD FEB
PY 2001
VL 144
IS 2
BP 397
EP 400
DI 10.1046/j.1365-2133.2001.04036.x
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 406VJ
UT WOS:000167236600033
PM 11251582
DA 2026-07-24
ER
PT J
AU Alvarez, AA
   Maxwell, GL
   Rodriguez, GC
AF Alvarez, AA
   Maxwell, GL
   Rodriguez, GC
TI Vacuum-assisted closure for cutaneous gastrointestinal fistula
   management
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
ID ENTEROCUTANEOUS FISTULA; WOUND CONTROL
AB Background. Cutaneous gastrointestinal (GI) fistulas are a challenging complication in the oncologic patient population. The fistulous effluent is difficult to manage and adversely alters quality of life. Nonsurgical management of enteric fistulas is successful in 30% of cases, requiring at least 4 to 6 weeks. Recently a new technology has been developed to expedite wound healing. The Vacuum-Assisted Closure (VAC) method is a subatmospheric pressure technique that has been demonstrated in laboratory and clinical studies to significantly improve wound healing. Here we report its use in the successful medical management of a cutaneous GI fistula.
   Case. A 63-year-old woman with advanced ovarian cancer developed an extensive complex cutaneous GI fistula in an open healing wound. She was treated with total parental nutrition and the VAC device, which resulted in complete closure of the fistula.
   Conclusion. We propose that the VAC device may be a useful adjunct for the medical management of cutaneous GI fistulas. (C) 2001 Academic Press.
C1 Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Durham, NC 27710 USA.
C3 Duke University
RP Alvarez, AA (通讯作者)，Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Box 3079, Durham, NC 27710 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Chamberlain RS, 1998, AM SURGEON, V64, P1204
   Chang P, 2000, SOUTH MED J, V93, P599
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
NR 5
TC 52
Z9 62
U1 0
U2 2
PU ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAR
PY 2001
VL 80
IS 3
BP 413
EP 416
DI 10.1006/gyno.2000.6092
PG 4
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA 410CM
UT WOS:000167422500017
PM 11263943
DA 2026-07-24
ER
PT J
AU Greer, SE
   Grossi, EA
   Chin, D
   Longaker, MT
AF Greer, SE
   Grossi, EA
   Chin, D
   Longaker, MT
TI Subatmospheric pressure dressing for saphenous vein donor-site
   complications
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Newer endoscopic techniques have been successful at reducing saphenous vein donor-site wound complications, but not entirely eliminating them. Tissue necrosis with superimposed infection is typically treated with antibiotics and surgical debridement. Typically, primary reclosure is not possible and the open leg wound is allowed to slowly granulate with dressing changes until a skin graft can be performed. This report describes an alternative treatment using subatmospheric pressure dressing to promote granulation tissue and wound closure in saphenous vein donor-site wounds. (C) 2001 by The Society of Thoracic Surgeons.
C1 NYU, Sch Med, Inst Reconstruct Plast Surg, New York, NY 10010 USA.
   NYU, Sch Med, Div Cardiothorac Surg, New York, NY 10010 USA.
C3 New York University; New York University
RP Greer, SE (通讯作者)，300 E 34th St,9th Floor, New York, NY 10016 USA.
OI GROSSI, eugene/0000-0002-2066-7035; Longaker,
   Michael/0000-0003-1430-8914
CR Allen KB, 1998, ANN THORAC SURG, V66, P26, DOI 10.1016/S0003-4975(98)00392-0
   DELARIA GA, 1981, J THORAC CARDIOV SUR, V81, P403
   Greer SE, 2000, ANN PLAS SURG, V45, P332, DOI 10.1097/00000637-200045030-00019
   Horvath KD, 1998, AM J SURG, V175, P391, DOI 10.1016/S0002-9610(98)00044-0
   Kent RC, 1996, SURGERY, V119, P378
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   UTLEY JR, 1989, J THORAC CARDIOV SUR, V98, P147
NR 8
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD MAR
PY 2001
VL 71
IS 3
BP 1038
EP 1040
DI 10.1016/S0003-4975(00)02431-0
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 410KM
UT WOS:000167439200077
PM 11269429
OA Bronze
DA 2026-07-24
ER
PT J
AU Hersh, RE
   Jack, JM
   Dahman, MI
   Morgan, RF
   Drake, DB
AF Hersh, RE
   Jack, JM
   Dahman, MI
   Morgan, RF
   Drake, DB
TI The vacuum-assisted closure device as a bridge to sternal wound closure
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   Southeastern-Society-for-Plastic-and-Reconstructive-Surgeons
CY JUN 04-08, 2000
CL BERMUDA
SP SE Soc Plast & Reconstruct Surgeons
ID MUSCLE FLAPS; NEGATIVE-PRESSURE; MEDIASTINITIS; EXPERIENCE; RUPTURE;
   REPAIR
AB Sixteen patients were treated for sternal wound infections after undergoing cardiac procedures. Their management involved prompt surgical debridement and quantitative wound biopsies. At the time of the initial debridement, the Vacuum-Assisted Closure Device (V.A.C.) was placed in the open sternal wound. A subatmospheric environment was maintained by the device at a level of 75 to 150 mmHg, The V.A.C, sponge was changed every 2 to 3 days, and operative debridement was performed until quantitative biopsies showed resolution of infection or until systemic signs of sepsis had resolved. At this time the sternal wounds were closed with regional muscle flaps. Patients were excluded from the use of the device if the pleural cavity was entered during operative debridement. Fifteen of the 16 patients survived and went on to complete wound healing and discharge from the hospital (average length of stay, 16.7 days). One patient sustained a cardiac dysrhythmia during the muscle flap procedure and died, There were no complications related directly to the use of the V.A.C. It is the opinion of the authors that the V.A.C. offers several advantages over their traditional methods of treatment. They noted improvement in sternal wound stabilization during the perioperative period and a decreased need for paralysis and mechanical ventilation. Wound management was improved by avoiding the need to perform debridement or to make desiccating dressing changes to an open sternum. Moreover, they also think that this device may lessen the risk for ventricular rupture because of better control of the wound environment and markedly improved stabilization of the debrided sternal elements.
C1 Univ Virginia Hlth Syst, Dept Plast Surg, Charlottesville, VA 22911 USA.
   Univ Kentucky, Lexington, KY USA.
   Ain Shams Univ, Cairo, Egypt.
   Univ Virginia, Charlottesville, VA USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Kentucky; Egyptian Knowledge Bank (EKB); Ain Shams
   University; University of Virginia
RP Drake, DB (通讯作者)，Univ Virginia Hlth Syst, Dept Plast Surg, POB 800376, Charlottesville, VA 22911 USA.
CR Arbulu A, 1996, EUR J CARDIO-THORAC, V10, P110, DOI 10.1016/S1010-7940(96)80132-1
   Argenta L, 1993, JOINT M WOUND HEAL S
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1994, 73 ANN M AM ASS PLAS
   BACKER CL, 1994, ANN THORAC SURG, V57, P797, DOI 10.1016/0003-4975(94)90179-1
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   HIGGINS RSD, 1991, ANN THORAC SURG, V52, P1161, DOI 10.1016/0003-4975(91)91302-C
   Jones G, 1997, ANN SURG, V225, P766, DOI 10.1097/00000658-199706000-00014
   JULIAN OC, 1957, SURGERY, V42, P753
   JURKIEWICZ MJ, 1980, ANN SURG, V191, P738, DOI 10.1097/00000658-198006000-00012
   LOOP FD, 1990, ANN THORAC SURG, V49, P179, DOI 10.1016/0003-4975(90)90136-T
   MILANO CA, 1995, CIRCULATION, V92, P2245, DOI 10.1161/01.CIR.92.8.2245
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Schumaker Jr H.B., 1963, ARCH SURG-CHICAGO, V86, P384
   Smith LA, 1997, AM SURGEON, V63, P1102
   WEINSTEIN RA, 1976, ANN THORAC SURG, V21, P442, DOI 10.1016/S0003-4975(10)63896-9
   YUEN JC, 1991, ANN PLAS SURG, V27, P358, DOI 10.1097/00000637-199110000-00013
NR 20
TC 77
Z9 85
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAR
PY 2001
VL 46
IS 3
BP 250
EP 254
DI 10.1097/00000637-200103000-00008
PG 5
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 411BL
UT WOS:000167478200014
PM 11293515
DA 2026-07-24
ER
PT J
AU Sposato, G
   Molea, G
   Di Caprio, G
   Scioli, M
   La Rusca, I
   Ziccardi, P
AF Sposato, G
   Molea, G
   Di Caprio, G
   Scioli, M
   La Rusca, I
   Ziccardi, P
TI Ambulant vacuum-assisted closure of skin-graft dressing in the lower
   limbs using a portable mini-VAC device
SO BRITISH JOURNAL OF PLASTIC SURGERY
LA English
DT Article
DE vacuum-assisted wound closure; lower limb; skin graft
AB A skin graft may fail to adhere to the recipient site because of fluid collecting between the graft and the area being treated. We have devised a simple procedure, consisting of a vacuum-sealed dressing, to fix skin grafts on the lower limbs. A fully portable, battery-operated aspirator continuously draws secretions through a vacuum-sealed dressing, preventing accumulation of fluid underneath the graft. Patients are not confined to bed, thus reducing nursing time. The procedure was applied successfully in seven out of nine patients treated for ulcers of the lower limbs. (C) 2001 The British Association of Plastic Surgeons.
C1 Univ Naples Federico II, Inst Plast & Reconstruct Surg, Naples, Italy.
   Salvatore Maugeri Fdn, Inst Care & Sci Res Rehabil, Inst Telese Terme Benevento, Telese Terme, Benevento, Italy.
C3 University of Naples Federico II; Istituti Clinici Scientifici Maugeri
   IRCCS
RP Molea, G (通讯作者)，Univ Naples Federico II, Inst Plast & Reconstruct Surg, Via S Pansini 5, Naples, Italy.
RI Di Caprio, Giovanni/E-1377-2019; scioli, michelina/E-1312-2019
OI Di Caprio, Giovanni/0000-0002-4001-8876; scioli,
   michelina/0000-0002-1183-7450
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Balakrishnan Chenicheri, 1994, Journal of Burn Care and Rehabilitation, V15, P432, DOI 10.1097/00004630-199409000-00010
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Collier M, 1997, Nurs Times, V93, P32
   Deva A K, 1997, J Wound Care, V6, P311
   Francis A, 1998, Nurs Stand, V12, P41
   KOLDAS T, 1992, ANN PLAS SURG, V28, P386, DOI 10.1097/00000637-199204000-00017
   Morykwas M J, 1997, J South Orthop Assoc, V6, P279
   Ratner D, 1998, DERMATOL CLIN, V16, P75, DOI 10.1016/S0733-8635(05)70488-5
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Wolf Y, 1998, ANN PLAS SURG, V40, P149, DOI 10.1097/00000637-199802000-00008
NR 11
TC 50
Z9 61
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0007-1226
J9 BRIT J PLAST SURG
JI Br. J. Plast. Surg.
PD APR
PY 2001
VL 54
IS 3
BP 235
EP 237
DI 10.1054/bjps.2000.3537
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 419KE
UT WOS:000167947200012
PM 11254417
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Evans, D
   Land, L
AF Evans, D
   Land, L
TI Topical negative pressure for treating chronic wounds: a systematic
   review
SO BRITISH JOURNAL OF PLASTIC SURGERY
LA English
DT Review
DE topical negative pressure; chronic wound; healing; randomised controlled
   trial
ID VACUUM-ASSISTED CLOSURE; TRIAL
AB Some wounds take a long time to heal, fail to heal or recur, causing significant pain and discomfort to the patient and cost to the National Health Service. This review assesses the effectiveness of topical negative pressure (TNP) in treating chronic wounds. The Cochrane Wounds Group Specialised Trials Register was searched for randomised controlled trials (RCTs) that evaluated the effectiveness of TNP on chronic-wound healing. Eligibility for inclusion, data extraction and details of trial quality were conducted by two reviewers independently. A narrative synthesis of results was undertaken as only two small trials, with different outcome measures, fulfilled the selection criteria. Trial 1 considered any type of chronic wound, trial 2 considered diabetic foot ulcers. Both trials compared TNP with saline-gauze dressings. Trial 1 reported a statistically significant difference in the percentage change in wound volume after 6 weeks, in favour of TNP. Trial 2 reported a difference in the number of days to healing and a difference in the percentage change in wound surface area after 2 weeks, in favour of TNP. These two small trials provide weak evidence to suggest that TNP may be superior to saline-gauze dressings in terms of wound healing. However, due to the small sample sizes and the methodological limitations of the studies, these findings must be interpreted with extreme caution. The effects of TNP on cost, quality of life, pain and comfort were not reported. It was not possible to determine the optimum TNP regimen. Further high-quality RCTs that address these issues are required. (C) 2001 The British Association of Plastic Surgeons.
C1 Univ Cent England, Hlth & Social Care Res Ctr, Birmingham B15 3TN, W Midlands, England.
C3 Birmingham City University
RP Evans, D (通讯作者)，Univ Cent England, Hlth & Social Care Res Ctr, Ravensbury House,Westbourne Rd, Birmingham B15 3TN, W Midlands, England.
OI Land, Lucy/0000-0001-8634-8056
CR [Anonymous], WOUND REPAIR REGENER
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P E, 1999, J Wound Care, V8, P79
   BANWELL PE, 1998, WOUND REPAIR REGEN, pA460
   Baxandall T, 1997, Elder Care, V9, P22
   DASGUPTA R, 1996, INTRO VAC THERAPY TR, V3
   Dealey Carol., 1999, The care of wounds, V2nd
   Deva AK, 2000, MED J AUSTRALIA, V173, P128, DOI 10.5694/j.1326-5377.2000.tb125564.x
   Fabian TS, 2000, AM SURGEON, V66, P1136
   Fay M F, 1987, AORN J, V46, P442, DOI 10.1016/S0001-2092(07)66456-4
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   FOX JW, 1976, AM J SURG, V132, P673, DOI 10.1016/0002-9610(76)90372-X
   Greer SE, 2000, ANN PLAS SURG, V45, P332, DOI 10.1097/00000637-200045030-00019
   HOLMICH LR, 1998, WOUND REPAIR REGEN, pA470
   Joseph E, 2000, WOUNDS, V12, P60
   LADIN D, 2001, UNPUB ADV WOUND CARE
   MCCALLON SK, 2001, UNPUB ADV WOUND CARE
   Mendez-Eastman S, 1998, RN, V61, P20
   MORYKWAS M, 1995, 27 ANN C WOUND OST C
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   MORYKWAS MJ, 1993, ANN M FED AM SOC EXP
   MORYKWAS MJ, 1998, WOUND HEALING SOC NE, V8, P4
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   MULROW C, 1997, COCHRANE LIBRARY DAT
   *NHS CTR REV DISS, 1996, CRD GUID THOS CARR O
   OVINGTON LG, 1999, ADV WOUND CARE, P125
   Philippidis TP, 1999, COMPOS STRUCT, V45, P41, DOI 10.1016/S0263-8223(99)00012-4
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   1999, TECHNOLOGY ASSESSMEN
NR 30
TC 72
Z9 81
U1 1
U2 7
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0007-1226
J9 BRIT J PLAST SURG
JI Br. J. Plast. Surg.
PD APR
PY 2001
VL 54
IS 3
BP 238
EP 242
DI 10.1054/bjps.2001.3547
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 419KE
UT WOS:000167947200013
PM 11254418
OA Bronze
DA 2026-07-24
ER
PT J
AU Giovannini, UM
   Demaria, RG
   Teot, L
AF Giovannini, UM
   Demaria, RG
   Teot, L
TI Interest of negative pressure therapy in the treatment of postoperative
   sepsis in cardiovascular surgery
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL
AB The treatment of postoperative wound dehiscence in cardiovascular surgery remains challenging, especially when a vascular prosthesis or the internal bone is exposed or infected. In 1986, Argenta, et al., suggested negative pressure for managing difficult acute and chronic wounds. This method involves applying continuous suction to the surface of the wound to promote wound healing. We used the vacuum-assisted closure (VAC) system in 15 patients with postoperative sternal dehiscence or unheated vascular approaches. All 15 wounds were infected. In most cases, VAC therapy was associated with decreases in defect size and infection and with rapid filling of the defect with granulation tissue. These improvements allowed wound closure without reconstructive surgery or easy coverage by skin grafting or pedicled muscle Flaps. This study odds to existing evidence that continuous suction promotes healing of infected surgical wounds after cardiovascular surgery.
C1 CHU Mountpellier, Dept Burns & Plastic Surg, F-34259 Mountpellier, France.
   Univ Milan, Inst Human Biopathol, Milan, Italy.
   CHU Mountpellier, Dept Cardiovasc Surg, F-34259 Mountpellier, France.
C3 University of Milan
RP Teot, L (通讯作者)，CHU Mountpellier, Dept Burns & Plastic Surg, 371 Av D Giraud, F-34259 Mountpellier, France.
EM lteot@aol.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   DEMARIA R, 1999, J AUT SOC CHIR THOR
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Morykwas M J, 1997, J South Orthop Assoc, V6, P279
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Philippidis TP, 1999, COMPOS STRUCT, V45, P41, DOI 10.1016/S0263-8223(99)00012-4
   SERRY C, 1980, J THORAC CARDIOV SUR, V80, P861
   Tang A T, 2000, J Wound Care, V9, P229
   TEOT L, 2000, 10 ANN M EUR TISS RE
NR 10
TC 10
Z9 13
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR-APR
PY 2001
VL 13
IS 2
BP 82
EP 87
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 430WT
UT WOS:000168599000007
DA 2026-07-24
ER
PT J
AU Josty, IC
   Ramaswamy, R
   Laing, JHE
AF Josty, IC
   Ramaswamy, R
   Laing, JHE
TI Vacuum-assisted closure: an alternative strategy in the management of
   degloving injuries of the foot
SO BRITISH JOURNAL OF PLASTIC SURGERY
LA English
DT Article
DE degloving injury; reconstruction; vacuum-assisted closure;
   rehabilitation
ID REVASCULARIZATION; SKIN
AB A case of a degloving injury to the foot is presented in a patient who also sustained severe contralateral lower-limb trauma. We report a technique for salvaging the foot by replacing the degloved skin as a full-thickness graft and securing it using the vacuum-assisted closure (VAC (TM)) device. A good outcome was achieved and technical tips are provided to facilitate reproduction of the procedure. (C) 2001 The British Association of Plastic Surgeons.
C1 Morriston Hosp, Welsh Ctr Burns & Plast Surg, Swansea SA6 6NL, W Glam, Wales.
C3 Morriston Hospital
RP Josty, IC (通讯作者)，Morriston Hosp, Welsh Ctr Burns & Plast Surg, Swansea SA6 6NL, W Glam, Wales.
RI Laing, Hamish/AAN-3921-2020
OI Laing, Hamish/0000-0002-5661-7937
CR Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   DeFranzo AJ, 1999, PLAST RECONSTR SURG, V104, P2145, DOI 10.1097/00006534-199912000-00031
   GRAF P, 1995, MICROSURG, V16, P149, DOI 10.1002/micr.1920160307
   HIDALGO DA, 1986, CLIN PLAST SURG, V13, P701
   Jeng SF, 1997, PLAST RECONSTR SURG, V100, P1434, DOI 10.1097/00006534-199711000-00009
   LAI MF, 1979, MED J AUSTRALIA, V1, P598, DOI 10.5694/j.1326-5377.1979.tb119390.x
   Meara JG, 1999, ANN PLAS SURG, V42, P589, DOI 10.1097/00000637-199906000-00002
   RAUTIO J, 1991, CLIN PLAST SURG, V18, P615
   Voinchet V, 1996, Ann Chir Plast Esthet, V41, P583
   Waikakul S, 1997, INJURY, V28, P271, DOI 10.1016/S0020-1383(97)00011-9
NR 10
TC 28
Z9 40
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0007-1226
J9 BRIT J PLAST SURG
JI Br. J. Plast. Surg.
PD JUN
PY 2001
VL 54
IS 4
BP 363
EP 365
DI 10.1054/bjps.2000.3565
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 438MH
UT WOS:000169057300019
PM 11355997
OA Bronze
DA 2026-07-24
ER
PT J
AU Gouttefangeas, C
   Eberle, M
   Ruck, P
   Stark, M
   Müller, JE
   Becker, HD
   Rammensee, HG
   Pinocy, J
AF Gouttefangeas, C
   Eberle, M
   Ruck, P
   Stark, M
   Müller, JE
   Becker, HD
   Rammensee, HG
   Pinocy, J
TI Functional T lymphocytes infiltrate implanted polyvinyl alcohol foams
   during surgical wound closure therapy
SO CLINICAL AND EXPERIMENTAL IMMUNOLOGY
LA English
DT Article
DE bacteria; leucocyte; vaccum-assisted closure; wound healing
ID SPONGE MATRIX MODEL; VACUUM-ASSISTED CLOSURE; LEUKOCYTE; CELLS;
   RECRUITMENT; MACROPHAGE; MECHANISMS; CYTOKINES; IMMUNITY; REPAIR
AB Vacuum-assisted closure involving the implantation of polyvinyl alcohol foam is a technique recently developed for the treatment of patients suffering from either wound infection or chronic wounds. This method has been shown to improve and accelerate wound healing. However, little is known about the cell populations that infiltrate the foam, and their potential role in resolving the infection and promoting granulation tissue formation. Our study demonstrates that wound-implanted foams are mainly infiltrated with granulocytes, but that mononuclear cells, including macrophages and minor populations of T, B and natural killer lymphocytes, are also present. We show that foam-infiltrating T cells, especially CD4(+) T cells, constitute a phenotypically and functionally heterogeneous population influenced by wound-infecting bacteria. Thus, T lymphocytes could play a role in wound cleansing. In addition, our data indicate that implanted polyvinyl alcohol foams might be suitable microenvironments for manipulating T cell-mediated immune responses in patients.
C1 Univ Tubingen, Inst Cell Biol, Dept Immunol, D-72076 Tubingen, Germany.
   Univ Tubingen, Inst Pathol, Dept Histo & Cytopathol, D-7400 Tubingen, Germany.
   Univ Tubingen, Inst Hyg, Dept Med Microbiol, Tubingen, Germany.
   Berufsgenossenschaftliche Unfallklin, Ctr Trauma, Tubingen, Germany.
   Berufsgenossenschaftliche Unfallklin, Dept Traumatol, Tubingen, Germany.
   Univ Tubingen, Dept Surg, Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University of
   Tubingen; Eberhard Karls University Hospital; Eberhard Karls University
   of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital; Eberhard Karls University of Tubingen; Eberhard
   Karls University Hospital; Eberhard Karls University of Tubingen
RP Rammensee, HG (通讯作者)，Univ Tubingen, Inst Cell Biol, Dept Immunol, Morgenstelle 15, D-72076 Tubingen, Germany.
EM rammensee@uni-tuebingen.de
RI Ruck, Patrick/NVM-8950-2025
CR AKPORIAYE ET, 1985, CANCER RES, V45, P6457
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BARBUL A, 1989, ANN SURG, V209, P479, DOI 10.1097/00000658-198904000-00015
   BARBUL A, 1984, SURGERY, V96, P315
   BARBUL A, 1986, J SURG RES, V40, P315, DOI 10.1016/0022-4804(86)90193-9
   EFRON JE, 1990, J SURG RES, V48, P460, DOI 10.1016/0022-4804(90)90013-R
   FISHEL RS, 1987, ANN SURG, V206, P25, DOI 10.1097/00000658-198707000-00004
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
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NR 30
TC 28
Z9 58
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0009-9104
EI 1365-2249
J9 CLIN EXP IMMUNOL
JI Clin. Exp. Immunol.
PD JUN
PY 2001
VL 124
IS 3
BP 398
EP 405
DI 10.1046/j.1365-2249.2001.01547.x
PG 8
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 452VT
UT WOS:000169880900009
PM 11472400
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hersh, RE
   Kaza, AK
   Long, SM
   Fiser, SM
   Drake, DB
   Tribble, CG
AF Hersh, RE
   Kaza, AK
   Long, SM
   Fiser, SM
   Drake, DB
   Tribble, CG
TI A technique for the treatment of sternal infections using the Vacuum
   Assisted Closure™ device
SO HEART SURGERY FORUM
LA English
DT Article
ID PREVENTABLE COMPLICATION; NEGATIVE-PRESSURE; WOUND CONTROL; MUSCLE
   FLAPS; EXPERIENCE; MEDIASTINITIS
AB Background: Sternal infections after median sternotomy remain a serious cause of postoperative morbidity and mortality. The treatment of sternal infections has evolved over the past few decades, and now aggressive surgical debridement with rotational muscle flap closure has provided an acceptable means of managing this complication. However, there are several disadvantages with this approach, mainly related to the morbidity associated with serial debridements with dressing changes and open packing until the wound is closed. Other disadvantages include potential morbidity and mortality associated with the shearing forces between the beating heart and the debrided sternal edges, and the need to paralyze the patient during the period after debridement.
   Methods: Our method of managing sternal infections is based on the triad of prompt surgical debridement, serial quantitative wound cultures, and the use of the Vacuum Assisted Closure(TM) (VAC) device (KCI International, San Antonio, TX). Following debridement and irrigation, a biopsy of the healthy appearing bone is sent for quantitative culture. If culture results are favorable, the wound is then fitted with the VAC(TM) device, which consists of a non-collapsible, open-cell, polyurethane sponge with embedded vacuum tubing, a vacuum pump, and transparent adhesive dressing. When systemic signs of infection and quantitative cultures indicate the resolution of the local infection, regional muscle flap or primary wound closure is performed.
   Conclusions: The VAC(TM) serves as a bridge to sternal wound closure and is a safe and effective therapeutic strategy for patients with impaired physiologic reserve and/or highly contaminated wounds. We feel that it is also reasonable to consider the VAC(TM) as a preventive strategy against right ventricular rupture. Furthermore, because the firmness of the vacuum sponge apparatus acts as an impressive sternal stabilizer, post-debridement extubation is possible, reducing the need for prolonged paralysis and mechanical ventilation. This stabilization also allows early postoperative ambulation with the VAC(TM) in place. In summary, we believe that the VAC(TM) device offers an effective means of managing patients with sternal infections.
C1 Univ Virginia Hlth Syst, Div Thorac & Cardiovasc Surg, Dept Surg, Charlottesville, VA 22908 USA.
   Univ Virginia Hlth Syst, Dept Plast Surg, Charlottesville, VA 22908 USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System
RP Tribble, CG (通讯作者)，Univ Virginia Hlth Syst, Div Thorac & Cardiovasc Surg, Dept Surg, POB 801359, Charlottesville, VA 22908 USA.
EM ctribble@virginia.edu
RI Kaza, Aditya/AAE-2116-2019
OI Kaza, Aditya/0000-0003-3450-4496
CR Arbulu A, 1996, EUR J CARDIO-THORAC, V10, P110, DOI 10.1016/S1010-7940(96)80132-1
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   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 16
TC 19
Z9 24
U1 0
U2 3
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
J9 HEART SURG FORUM
JI Heart Surg. Forum
PY 2001
VL 4
IS 3
BP 211
EP 215
AR 2001-43986
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 474UZ
UT WOS:000171126400003
PM 11673139
DA 2026-07-24
ER
PT J
AU Brown, KM
   Harper, FV
   Aston, WJ
   O'Keefe, PA
   Cameron, CR
AF Brown, KM
   Harper, FV
   Aston, WJ
   O'Keefe, PA
   Cameron, CR
TI Vacuum-assisted closure in the treatment of a 9-year-old child with
   severe and multiple dog bite injuries of the thorax
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
AB The vacuum-assisted closure (VAC; KCI International, San Antonio, TX) device is a negative pressure dressing, which we have used in the treatment of wounds with devitalized or infected tissues. Although introduced in plastic and reconstructive surgery, its use has extended to orthopedic and cardiothoracic surgical practice in the treatment of infected joint replacement and sternal wound infections, respectively. Although the VAC is becoming more widely used in surgical practice, only a small number of case reports exist in addition to the original case series by Argenta and Morykwas in 1997. Previously, the device was described in treating single wounds in adult patients. We report a case where it was successfully used to treat multiple dog bite injuries in a 9-year-old child. (C) 2001 by The Society of Thoracic Surgeons.
C1 Guys Hosp, Dept Cardiothorac Surg, London SE1 9RT, England.
   Guys Hosp, Dept Plast Surg, London SE1 9RT, England.
C3 Guy's & St Thomas' NHS Foundation Trust; Guy's & St Thomas' NHS
   Foundation Trust
RP Brown, KM (通讯作者)，Guys & St Thomas Hosp, Dept Cardiothorac Surg, Guys & St Thomas NHS Trust, London SE1 9RT, England.
RI Brown, Kimberly/AGS-6387-2022
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 3
TC 16
Z9 22
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2001
VL 72
IS 4
BP 1409
EP 1410
DI 10.1016/S0003-4975(01)02844-2
PG 2
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 479MB
UT WOS:000171407200097
PM 11603487
DA 2026-07-24
ER
PT J
AU DeFranzo, AJ
   Argenta, LC
   Marks, MW
   Molnar, JA
   David, LR
   Webb, LX
   Ward, WG
   Teasdall, RG
AF DeFranzo, AJ
   Argenta, LC
   Marks, MW
   Molnar, JA
   David, LR
   Webb, LX
   Ward, WG
   Teasdall, RG
TI The use of vacuum-assisted closure therapy for the treatment of
   lower-extremity wounds with exposed bone
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 68th Annual Meeting of the
   American-Society-of-Plastic-and-Reconstructive-Surgeons
CY OCT 23-27, 1999
CL NEW ORLEANS, LA
SP Amer Soc Plast & Reconstruct Surgeons
ID SKIN
AB Lower-extremity wounds with exposed tendon, bone, or orthopedic hardware present a difficult treatment challenge. In this series of patients, subatmospheric pressure therapy was applied to such lower-extremity wounds. Seventy-five patients with lower-extremity Wounds, most of which were the result of trauma, were selected for this study. Dressings made of sterile open-cell foam with embedded fenestrated tithing were contoured to the Wound size and placed into the wound. The site was covered with an adhesive plastic sheet. The Sheet was placed beneath any external fixation devices, or the fixation device was enclosed within the sheet. The tubing was connected to the vacuum-assisted closure pump. Continuous subatmospheric suction pressure (125 mmHg) was applied to the wound site. The wounds were inspected and the dressings were changed every, 48 hours.
   Vacuum-assisted closure therapy greatly reduced the amount of tissue edema, diminishing the circumference of the extremity and thus decreasing the surface area of the wound. Profuse granulation tissue formed rapidly, covering bone and hardware. The wounds were closed primarily and covered with split-thickness skin grafts, or a regional flap was rotated into the granulating bed to fill the defect. Successful coverage was obtained without complication in 71 of 75 patients. Wounds have been stable from 6 months up to 6 years.
C1 Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
   Wake Forest Univ, Sch Med, Dept Orthoped Surg, Winston Salem, NC 27109 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University
RP DeFranzo, AJ (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
RI /AAM-1164-2020; Molnar, Joseph/AEK-5540-2022
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   CHERRY GW, 1983, PLAST RECONSTR SURG, V72, P680, DOI 10.1097/00006534-198311000-00018
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   OLENIUS M, 1993, PLAST RECONSTR SURG, V91, P213, DOI 10.1097/00006534-199302000-00001
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   Thoma R., 1911, VIRCHOWS ARCH PATHOL, V204, P1
   URSCHEL JD, 1988, BRIT J PLAST SURG, V41, P182, DOI 10.1016/0007-1226(88)90049-5
NR 7
TC 328
Z9 393
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2001
VL 108
IS 5
BP 1184
EP 1191
DI 10.1097/00006534-200110000-00013
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 479XJ
UT WOS:000171428900013
PM 11604617
DA 2026-07-24
ER
PT J
AU Webb, LX
   Schmidt, U
AF Webb, LX
   Schmidt, U
TI Vacuum therapy for wound management
SO UNFALLCHIRURG
LA German
DT Article
DE vacuum assisted closure; vacuum sealing technique; traumatic wounds;
   wound therapy
ID SUBATMOSPHERIC PRESSURE; ASSISTED CLOSURE; COLONIZATION; DRESSINGS;
   ULCERS
AB Vacuum assisted wound closure (VAC) is a closed system, which applies negative pressure to the wound tissues. Basic studies have shown beneficial effects on wound blood flow and proliferation of healing granulation tissue. Theoretically, the method acts by removal of excess tissue fluid from the extravascular space, which lowers capillary afterload and thereby promotes the microcirculation during the early stages of inflammation. Additionally, the mechanical effect of the vacuum on the tissue at the wound surface appears to have an "llizarovian" effect resulting in an exuberant proliferation of healing granulation tissue.
   This technique has been used in over 2560 patients at the author's institution over the past 10 years for an expanding list of wound applications in several surgical disciplines. Commonly used orthopedic indications include traumatic wounds following debridement, infection (following debridement), fasciotomy wounds for compartment syndrome, and as a dressing for anchoring an applied split thickness skin graft.
   The author's personal experience consists of 269 patients treated and has not been associated with any major complications. A low incidence (2.5%) of localized superficial skin irritation occurred when a portion of the vacuum sponge overlapped the affected area. This problem is avoided by carefully confining the sponge to the wound tissue and avoiding the overlap of normal skin. The technique is contraindicated in patients with an allergy to any of the components which contact the skin such as the polyurethane sponge, the adhesive, or the plastic film applied to seal the system to the skin around the wound. Patients whose skin is thin and easily damaged will not tolerate the pulling off of the adhesive film, which is done at the time of sponge removal/change. Also, patients who are fully anticoagulated or patients with large wound surface areas (e.g., burns) may need careful monitoring of electrolytes, hematocrit, and/or fluid balance in an intensive care or burn unit setting.
   The mainstay of wound care is debridement, and vacuum assisted wound closure is not a substitute for this. ft is a novel and welcome addition to the methods available to surgeons charged with the management of challenging wounds, and its final role in the overall list of adjunctive wound treatment modalities is still seeking a final definition.
C1 Wake Forest Univ, Med Ctr, Dept Orthopaed Surg, Winston Salem, NC USA.
C3 Wake Forest University
RP Schmidt, U (通讯作者)，Hannover Med Sch, Unfallchirurg Klin, Carl Neuberg Str 1, D-30623 Hannover, Germany.
EM schmidt.ulf@mh-hannover.de
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 1999, J SURG ONCOL, V72, P14, DOI 10.1002/(SICI)1096-9098(199909)72:1<14::AID-JSO4>3.0.CO;2-3
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NR 29
TC 51
Z9 57
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD OCT
PY 2001
VL 104
IS 10
BP 918
EP 926
DI 10.1007/PL00002776
PG 9
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 483AF
UT WOS:000171611000002
PM 11699301
DA 2026-07-24
ER
PT J
AU Wiseman, J
   Cullington, JR
   Schaeferle, M
   Beckham, PH
   Salisbury, M
   Ersek, RA
AF Wiseman, J
   Cullington, JR
   Schaeferle, M
   Beckham, PH
   Salisbury, M
   Ersek, RA
TI Aesthetic aspects of neurofibromatosis reconstruction with the
   vacuum-assisted closure system
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE neurofibromatosis; vacuum assisted closure technique; negative pressure
AB Everyone agrees that any reconstructive procedure should carry with it the maximum of aesthetic considerations in order that the reconstructive procedure presents the minimal deformities. Vacuum-assisted closure-(VAC) has allowed surgeons to achieve this goal by creating the most optimal conditions for proper wound healing and thus the best aesthetic results. We present a tragic case whereby a 28-year-old Hispanic male patient with neurofibromatosis was treated for a soccer ball-sized tumor located on his upper left leg. The treatment plan consisted of partial excision with local flap coverage of the wound; however, due to persistent bleeding and tumor growth within the flap, the flap did not survive and we were left with an open wound measuring 20 x 40 cm extending from the patient's upper knee to his iliac crest. Had we attempted an autograft procedure at this time, there would scarcely have been enough donor skin areas to cover the wound. VAC was implemented in an attempt to control the bleeding and to possibly decrease the size of the wound. With the application of this procedure, the previously uncontrollable bleeding (12 units) stopped immediately, and the wound size shrank to 1/2 of its original dimensions. As a result, the area for skin grafting was decreased and was completed with 100% take. The VAC system turned out to be advantageous in achieving the most optimal conditions for our patient's wound to close and heal properly, allowing for enhancement of the aesthetic considerations for the patient.
CR [Anonymous], ANN PLAST SURG
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   NEUROFIBROMATOSIS NI, V6, P1
NR 4
TC 6
Z9 13
U1 0
U2 0
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0364-216X
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD SEP-OCT
PY 2001
VL 25
IS 5
BP 326
EP 331
DI 10.1007/s00266-001-0013-y
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 488RQ
UT WOS:000171949800002
PM 11692244
DA 2026-07-24
ER
PT J
AU Morykwas, MJ
   Faler, BJ
   Pearce, DJ
   Argenta, LC
AF Morykwas, MJ
   Faler, BJ
   Pearce, DJ
   Argenta, LC
TI Effects of varying levels of subatmospheric pressure on the rate of
   granulation tissue formation in experimental wounds in swine
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TRIAL
AB The use of subatmospheric pressure to promote wound healing has increased in popularity during the last several years. The original studies on granulation tissue formation used a 125-mmHg vacuum. The use of alternative sources of subatmospheric pressure has led to many questions regarding efficacy or risk. In this report a swine model is used to quantify and compare the effects of low vacuum suction (25 mmHg) and high vacuum suction (500 mmHg) produced by various vacuum pumps and wall suction systems with the standard 125-mmHg vacuum. Additionally, the effects of an unregulated air leak in the sealing system were examined. All four wound treatments were examined on each of 4 pigs. Wounds were treated until one of the wounds had granulated to a level flush with the surrounding tissue. Wounds treated with the standard 125-mmHg vacuum had filled with granulation tissue by day 8. At this time wounds treated with 25 mmHg had filled 21.2% with new granulation tissue, and wounds treated with 500 mmHg had filled 5.9% with new tissue. Wounds treated with 125 mmHg with a hole in the sealing drape had increased in size 197% because of the debridement of necrotic tissue. In conclusion, wounds treated with a 125-mmHg vacuum exhibited a significant (p < 0.0001) increase in the rate of granulation tissue formation compared with treatment at 25 mmHg or 500 mmHg. The presence of an unregulated air leak in the sealing drape results in significant progression (p < 0.0001) of the wound secondary to dehydration and progressive necrosis.
C1 Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
OI Morykwas, Michael/0009-0001-5547-5172
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ARGENTA LC, 1990, ESSENTIALS PLASTIC M, P103
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P249, DOI 10.1097/00003086-198901000-00038
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P263
   Joseph E, 2000, WOUNDS, V12, P60
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
NR 7
TC 264
Z9 336
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD NOV
PY 2001
VL 47
IS 5
BP 547
EP 551
DI 10.1097/00000637-200111000-00013
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 491JK
UT WOS:000172105100013
PM 11716268
DA 2026-07-24
ER
PT J
AU Gwan-Nulla, DN
   Casal, RS
AF Gwan-Nulla, DN
   Casal, RS
TI Toxic shock syndrome associated with the use of the vacuum-assisted
   closure device
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
AB The vacuum-assisted wound closure technique and device (the V.A.C.) has become a widely accepted technique in the management of chronic and difficult wounds. The authors present the first reported case of toxic shock syndrome associated with its use. This article does not question the efficacy of the V.A.C. technique in the treatment of difficult wounds, but focuses on raising the index of suspicion of toxic shock syndrome in patients with wounds managed with the V.A.C. who develop early signs or symptoms that may be consistent with the diagnosis.
C1 Penn State Univ, Milton S Hershey Med Ctr, Dept Surg, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Gwan-Nulla, DN (通讯作者)，Div Cardiothorac Surg, Harper Profess Bldg,Suite 2102,3990 John R, Detroit, MI 48201 USA.
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NR 9
TC 68
Z9 105
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD NOV
PY 2001
VL 47
IS 5
BP 552
EP 554
DI 10.1097/00000637-200111000-00014
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 491JK
UT WOS:000172105100014
PM 11716269
DA 2026-07-24
ER
PT J
AU Roberts, S
   Creamer, K
   Shoupe, B
   Flores, Y
   Robie, D
AF Roberts, S
   Creamer, K
   Shoupe, B
   Flores, Y
   Robie, D
TI Unique management of stage 4S neuroblastoma complicated by massive
   hepatomegaly: Case report and review of the literature
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Review
DE stage 4S neuroblastoma; abdominal wall expansion; negative-pressure
   dressing; diffuse alveolar hemorrhage
ID IV-S NEUROBLASTOMA; DIFFUSE ALVEOLAR HEMORRHAGE; BONE-MARROW
   TRANSPLANTATION; VACUUM-ASSISTED CLOSURE; NEURO-BLASTOMA; ABDOMINAL
   EXPANSION; WOUND CONTROL; THERAPY; CORTICOSTEROIDS; CRITERIA
AB Stage 4S neuroblastoma is an unusual malignancy that has an excellent prognosis, except in young infants. A 2-month-old with 4S neuroblastoma complicated by massive hepatomegaly, managed by abdominal decompression surgery and a negative-pressure dressing system is presented. Diffuse alveolar hemorrhage also developed, which was treated with high-dose corticosteroids.
C1 Tripler Army Med Ctr, Dept Pediat, Tripler, HI USA.
   Tripler Army Med Ctr, Dept Crit Care, Tripler, HI USA.
   Tripler Army Med Ctr, Dept Surg, Tripler, HI USA.
C3 United States Department of Defense; United States Army; Tripler Army
   Medical Center; United States Department of Defense; United States Army;
   Tripler Army Medical Center; United States Department of Defense; United
   States Army; Tripler Army Medical Center
RP Roberts, S (通讯作者)，Doernbecher Mem Hosp Children, 3181 SW Sam Jackson Pk Rd CDRCP, Portland, OR 97219 USA.
EM roherste@ohsu.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BLATT J, 1987, INT J RADIAT ONCOL, V13, P1467, DOI 10.1016/0360-3016(87)90312-9
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   Müller-Berghaus J, 1999, PEDIATR HEMAT ONCOL, V16, P453, DOI 10.1080/088800199277010
   Nickerson HJ, 2000, J CLIN ONCOL, V18, P477, DOI 10.1200/JCO.2000.18.3.477
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NR 18
TC 12
Z9 13
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1077-4114
EI 1536-3678
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD FEB
PY 2002
VL 24
IS 2
BP 142
EP 144
DI 10.1097/00043426-200202000-00017
PG 3
WC Oncology; Hematology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Hematology; Pediatrics
GA 520YD
UT WOS:000173810600015
PM 11990702
DA 2026-07-24
ER
PT J
AU Argenta, PA
   Rahaman, J
   Gretz, HF
   Nezhat, F
   Cohen, CJ
AF Argenta, PA
   Rahaman, J
   Gretz, HF
   Nezhat, F
   Cohen, CJ
TI Vacuum-assisted closure in the treatment of complex gynecologic wound
   failures
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
AB BACKGROUND: Complex wound failures are a source of significant morbidity and mortality. They are costly and time consuming to treat, and may evolve into chronic, debilitating conditions. Vacuum-assisted closure is a novel wound healing technique applying subatmospheric pressure to wounds to expedite healing.
   CASES: We report the successful use of vacuum-assisted closure therapy on three patients on a gynecologic oncology service with complex wound failures of various chronicity. In all cases, vacuum-assisted closure therapy was well tolerated and demonstrated efficacy within 48 hours of initiation.
   CONCLUSION: We conclude that vacuum-assisted closure therapy should be included in the armamentarium of the gynecologist addressing complex wound failures. (C) 2002 by the American College of Obstetricians and Gynecologists.
C1 CUNY, Mt Sinai Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; City University of New York
   (CUNY) System
RP Argenta, PA (通讯作者)，CUNY, Mt Sinai Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, 1 Gustave L Levy Pl,Box 1170, New York, NY 10029 USA.
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bonnamy C, 2000, ANN CHIR, V125, P982, DOI 10.1016/S0003-3944(00)00411-9
   Chamberlain RS, 1998, AM SURGEON, V64, P1204
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 1999, J SURG ONCOL, V72, P14, DOI 10.1002/(SICI)1096-9098(199909)72:1<14::AID-JSO4>3.0.CO;2-3
   ORR JW, 1994, COMPLICATIONS GYNECO, P167
   von Gossler C M, 2000, J Cutan Med Surg, V4, P219
   Yuan-Innes M J, 2001, Spine (Phila Pa 1976), V26, pE30
NR 10
TC 38
Z9 47
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD MAR
PY 2002
VL 99
IS 3
BP 497
EP 501
AR PII S0029-7844(01)01752-5
DI 10.1016/S0029-7844(01)01752-5
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 524JU
UT WOS:000174010300021
PM 11864680
DA 2026-07-24
ER
PT J
AU Gustafsson, R
   Johnsson, P
   Algotsson, L
   Blomquist, S
   Ingemansson, R
AF Gustafsson, R
   Johnsson, P
   Algotsson, L
   Blomquist, S
   Ingemansson, R
TI Vacuum-assisted closure therapy guided by C-reactive protein level in
   patients with deep sternal wound infection
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID MEDIAN STERNOTOMY; MUSCLE FLAPS; COMPLICATIONS; EXPERIENCE; SURGERY;
   MEDIASTINITIS
AB Background: Deep sternal wound infection is a serious and potentially lethal complication of cardiac surgery when performed through a median sternotomy. We describe the outcome of a new treatment strategy with C-reactive protein level-guided vacuum-assisted closure used at our department.
   Methods: Data from 16 consecutive adult patients who had deep sternal wound infections after cardiac surgery were reviewed. Patients with superficial infection or sterile dehiscence were not included. All patients with postoperative deep sternal wound infections were treated with first-line vacuum-assisted closure therapy, followed by direct surgical closure. A purpose-built vacuum-assisted closure system consisting of polyurethane foam pieces and a special pump unit was used. The foam was placed in the wound after debridement of foreign material and necrotic tissue. The wound was covered with adhesive drape and connected to the pump unit, which was programmed to create a continuous negative pressure of 125 mm Hg in the wound cavity. Intravenous antibiotics were given according to tissue-culture results. The patients were immediately extubated after the operation. When ingrowth of granulation tissue was observed in all parts of the wound and the plasma C-reactive protein level showed a steady decline to 30 to 70 mg/L or less without confounding factors, such as tissue injuries or concomitant infections, the sternotomy was rewired, and the wound was closed.
   Results: All patients were alive and free from deep sternal wound infection 3 months after the operation. The median vacuum-assisted closure treatment time until surgical closure was 9 days (range, 3-34 days), and the median C-reactive protein level at closure was 45 mg/L (range, 20-173 mg/L). The median hospital stay was 22 days (range, 12-120 days).
   Conclusions: Early vacuum-assisted closure treatment, followed by surgical closure guided by the plasma C-reactive protein level, is a reliable and easily applied new strategy in patients with postoperative deep sternal wound infection.
C1 Univ Hosp, Heart & Lung Div, SE-22185 Lund, Sweden.
   Univ Hosp, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
   Univ Hosp, Dept Anesthesiol, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Gustafsson, R (通讯作者)，Univ Hosp, Heart & Lung Div, SE-22185 Lund, Sweden.
OI Ingemansson, Richard/0000-0001-7623-8953
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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   WOUTERS R, 1994, TEX HEART I J, V21, P183
NR 20
TC 90
Z9 106
U1 0
U2 0
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0022-5223
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD MAY
PY 2002
VL 123
IS 5
BP 895
EP 900
DI 10.1067/mtc.2002.121306
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 556CY
UT WOS:000175832800010
PM 12019374
OA Bronze
DA 2026-07-24
ER
PT J
AU Cro, C
   George, KJ
   Donnelly, J
   Irwin, ST
   Gardiner, KR
AF Cro, C
   George, KJ
   Donnelly, J
   Irwin, ST
   Gardiner, KR
TI Vacuum assisted closure system in the management of enterocutaneous
   fistulae
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Article
AB Background: A very important yet often troublesome element in the conservative management of enterocutaneous fistulae is the protection of the surrounding skin from contact with the effluent, This report describes the successful use of a vacuum assisted closure (VAC) system in dealing with this problem.
   Methods: The results of using the VAC system were studied in three patients with moderate or high volume output enterocutaneous fistulae where conventional treatment had failed to prevent skin excoriation.
   Results: The VAC system was found to be highly effective in controlling fistula effluent and in promoting healing of excoriated skin in all three patients. Complete healing of the fistula was also achieved in two of the three patients.
   Conclusion: The VAC system can be an effective and economically viable method of containing fistula effluent and protecting the skin of patients with enterocutaneous fistulae. Contrary to conventional thought, the VAC system may also actually promote healing of the fistula.
C1 Royal Victoria Hosp, Colorectal Surg Unit, Belfast BT12 6BA, Antrim, North Ireland.
   Royal Victoria Hosp, Intestinal Failure Clin, Belfast BT12 6BA, Antrim, North Ireland.
RP Gardiner, KR (通讯作者)，Royal Victoria Hosp, Colorectal Surg Unit, Grosvenor Rd, Belfast BT12 6BA, Antrim, North Ireland.
RI George, K Joshi/LUA-0409-2024
OI George, K Joshi/0000-0002-1149-2536
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Berry SM, 1996, SURG CLIN N AM, V76, P1009, DOI 10.1016/S0039-6109(05)70495-3
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   *KCI MED, 2000, UK PRIC LIST
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NR 8
TC 94
Z9 109
U1 0
U2 4
PU BRITISH MED JOURNAL PUBL GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0032-5473
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD JUN
PY 2002
VL 78
IS 920
BP 364
EP 365
DI 10.1136/pmj.78.920.364
PG 2
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 565WD
UT WOS:000176391700012
PM 12151694
OA Bronze
DA 2026-07-24
ER
PT J
AU Ford, CN
   Reinhard, ER
   Yeh, D
   Syrek, D
   de las Morenas, A
   Bergman, SB
   Williams, S
   Hamori, CA
AF Ford, CN
   Reinhard, ER
   Yeh, D
   Syrek, D
   de las Morenas, A
   Bergman, SB
   Williams, S
   Hamori, CA
TI Interim analysis of a prospective, randomized trial of vacuum-assisted
   closure versus the healthpoint system in the management of pressure
   ulcers
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT COonference on Cosmetic Surgery: Applying Techniques and Technology in
   Your Practice
CY JUL 01-08, 2002
CL HOLLAND, ALABAMA
ID SORES
AB Twenty-eight patients with 41 full-thickness decubitus ulcers were randomized to compare the Vacuum-Assisted Closure device (VAC) with the Healthpoint System (HP) of wound gel products in promoting ulcer healing. A total of 22 patients with 35 full-thickness ulcers completed the 6-week trial of treatment, during which time 2 patients (10%) in the VAC group (N = 20) and 2 patients (13%) in the HIP group (N = 15) healed completely. The mean percent reduction in ulcer volume was 42.1% with HIP and 51.8% with VAC (P = 0.46). The mean number of PMNs and lymphocytes per high-power field decreased in the VAC group and increased in the HIP group (p = 0.13, p = 0.41 respectively). The mean number of capillaries per high-power field was greater in the VAC group (p = 0.75). There were 15 cases of biopsy-proven osteomyelitis underlying the ulcers; three (37.5%) improved with VAC and none improved with HP (p = 0.25). VAC promotes an increased rate of wound healing and favorable histological changes in soft tissue and bone compared with HP.
C1 Boston Univ, Sch Med, Boston, MA 02215 USA.
C3 Boston University
RP Hamori, CA (通讯作者)，95 Tremont St,Suite 28, Duxbury, MA 02332 USA.
OI Hamori, Christine/0000-0003-0265-5345; De Las Morenas,
   Antonio/0000-0001-9908-4096
CR [Anonymous], 1994, Cost implications of the pressure ulcer treatment guideline
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 13
TC 146
Z9 168
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUL
PY 2002
VL 49
IS 1
BP 55
EP 61
DI 10.1097/00000637-200207000-00009
PG 7
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 570ZJ
UT WOS:000176690100015
PM 12142596
DA 2026-07-24
ER
PT J
AU Kirby, JP
   Fantus, RJ
   Ward, S
   Sanchez, O
   Walker, E
   Mellett, MM
   Maltz, SB
   Lerner, TT
AF Kirby, JP
   Fantus, RJ
   Ward, S
   Sanchez, O
   Walker, E
   Mellett, MM
   Maltz, SB
   Lerner, TT
TI Novel uses of a negative-pressure wound care system
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article; Proceedings Paper
CT Conference of the Chicage-Committee on Trauma Local Residents
CY 1998
CL CHICAGO, ILLINOIS
SP Chicage Comm
ID VACUUM-ASSISTED CLOSURE; INFECTION; HYPOXIA; CELLS
C1 Illinois Masonic Med Ctr, Dept Surg, Chicago, IL 60657 USA.
   Illinois Masonic Med Ctr, Dept Phys Therapy, Chicago, IL 60657 USA.
   Illinois Masonic Med Ctr, Dept Nursing, Chicago, IL 60657 USA.
RP Kirby, JP (通讯作者)，Illinois Masonic Med Ctr, Dept Surg, 836 W Wellington Ave, Chicago, IL 60657 USA.
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NR 24
TC 10
Z9 10
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD JUL
PY 2002
VL 53
IS 1
BP 117
EP 121
DI 10.1097/00005373-200207000-00024
PG 5
WC Critical Care Medicine; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 573BR
UT WOS:000176809900030
PM 12131402
DA 2026-07-24
ER
PT J
AU Espensen, EH
   Nixon, BP
   Lavery, LA
   Armstrong, DG
AF Espensen, EH
   Nixon, BP
   Lavery, LA
   Armstrong, DG
TI Use of subatmospheric (VAC) therapy to improve bioengineered tissue
   grafting in diabetic foot wounds
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID ULCERS
AB The use of bioengineered tissue and topical subatmospheric pressure therapy have both been widely accepted as adjunctive therapies for the treatment of noninfected, nonischemic diabetic foot wounds. This article describes a temporally overlapping method of care that includes a period of simultaneous application of bioengineered tissue (Apligraf, Novartis Pharmaceuticals Corp, East Hanover, New Jersey) and subatmospheric pressure therapy delivered through the VAC (Vacuum Assisted Closure) system (KCI, Inc, San Antonio, Texas). Future descriptive and analytic works may test the hypothesis that combined therapies used at different and often overlapping periods during the wound-healing cycle may be more effective than a single modality.
C1 Providence St Joseph Med Ctr, Diabet Foot Ctr, Burbank, CA USA.
RP Espensen, EH (通讯作者)，So Arizona Vet Affairs Med Ctr, Dept Surg, Podiatry Sect, 3601 S 6th Ave, Tucson, AZ 85723 USA.
CR Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Gentzkow GD, 1996, DIABETES CARE, V19, P350, DOI 10.2337/diacare.19.4.350
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Veves A, 2001, DIABETES CARE, V24, P290, DOI 10.2337/diacare.24.2.290
NR 5
TC 27
Z9 38
U1 0
U2 4
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD JUL-AUG
PY 2002
VL 92
IS 7
BP 395
EP 397
DI 10.7547/87507315-92-7-395
PG 3
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 576AC
UT WOS:000176979800007
PM 12122126
DA 2026-07-24
ER
PT J
AU Scherer, LA
   Shiver, S
   Chang, M
   Meredith, JW
   Owings, JT
AF Scherer, LA
   Shiver, S
   Chang, M
   Meredith, JW
   Owings, JT
TI The vacuum assisted closure device - A method of securing skin grafts
   and improving graft survival
SO ARCHIVES OF SURGERY
LA English
DT Article; Proceedings Paper
CT 73rd Annual Meeting of the Pacific-Coast-Surgical-Association
CY FEB 16-18, 2002
CL LAS VEGAS, NEVADA
SP Pacific Coast Surg Assoc
ID NEGATIVE-PRESSURE DRESSINGS; WOUND CONTROL; FIXATION; BOLSTER
AB Hypothesis: Use of the vacuum assisted closure device (VAC) for securing split-thickness skin grafts (STSGs) is associated with improved wound outcomes compared with bolster dressings.
   Design: Consecutive case series.
   Patients and Setting: Consecutive patients at a level I trauma center requiring STSG due to traumatic or thermal tissue loss during an 18-month period.
   Main Outcome Measure: Repeated skin grafting due to failure of the initial graft. Secondary outcome measures included dressing-associated complications, percentage of graft take, and length of hospital stay.
   Results: Sixty-one patients underwent STSG placement. Indications for STSG were burn injury (n=32), soft tissue loss (n=27), and fasciotomy-site coverage (n=2). Patients were treated with the VAC (n=34) or the bolster dressing (n=27). The VAC group required significantly fewer repeated STSGs (1 [3%] vs 5 [19%]; P=.04). Two additional graft failures occurred in the no-VAC group, but repeated STSGs were refused by these patients. No difference was seen between the groups in age, percentage of graft take, or hospital length of stay. The no-VAC group had significantly larger grafts (mean +/- SD, 984 996 vs 386 573 cm(2); P=.006). The patients requiring repeated STSGs (n=6) did not have significantly larger grafts than those not requiring repeated STSGs (mean +/- SD, 617+/-717 vs 658+/-857 cm(2); P=.62). No dressing-associated complications occurred in the VAC group.
   Conclusions: The VAC provides a safe and effective method for securing STSGs and is associated with improved graft survival as measured by a reduction in number of repeated STSGs.
C1 Univ Calif Davis, Med Ctr, Dept Surg, Sacramento, CA 95817 USA.
   Wake Forest Univ, Baptist Med Ctr, Dept Surg, Winston Salem, NC 27109 USA.
C3 University of California System; University of California Davis; Wake
   Forest University; Wake Forest Baptist Medical Center
RP Scherer, LA (通讯作者)，Univ Calif Davis, Med Ctr, Dept Surg, 2315 Stockton Blvd,Room 4209, Sacramento, CA 95817 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BEST T, 1995, J TRAUMA, V38, P915, DOI 10.1097/00005373-199506000-00016
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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   Fullerton JK, 2000, ANN PLAS SURG, V45, P462, DOI 10.1097/00000637-200045040-00022
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Ghosh SJ, 1997, BURNS, V23, P601, DOI 10.1016/S0305-4179(97)00066-1
   Hansbrough Wendy, 1995, Journal of Burn Care and Rehabilitation, V16, P531, DOI 10.1097/00004630-199509000-00012
   Langtry JAA, 1998, DERMATOL SURG, V24, P1350, DOI 10.1111/j.1524-4725.1998.tb00013.x
   Maggi SP, 1999, BURNS, V25, P237, DOI 10.1016/S0305-4179(98)00160-0
   Molnar JA, 2000, PLAST RECONSTR SURG, V105, P174, DOI 10.1097/00006534-200001000-00030
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Sposato G, 2001, BRIT J PLAST SURG, V54, P235, DOI 10.1054/bjps.2000.3537
   Wolf Y, 1998, ANN PLAS SURG, V40, P149, DOI 10.1097/00000637-199802000-00008
NR 16
TC 237
Z9 290
U1 1
U2 20
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 0004-0010
J9 ARCH SURG-CHICAGO
JI Arch. Surg.
PD AUG
PY 2002
VL 137
IS 8
BP 930
EP 933
DI 10.1001/archsurg.137.8.930
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 582AE
UT WOS:000177326900014
PM 12146992
DA 2026-07-24
ER
PT J
AU Morykwas, MJ
   Howell, H
   Bleyer, AJ
   Molnar, JA
   Argenta, LC
AF Morykwas, MJ
   Howell, H
   Bleyer, AJ
   Molnar, JA
   Argenta, LC
TI The effect of externally applied subatmospheric pressure on serum
   myoglobin levels after a prolonged crush/ischemia injury
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE subatmospheric pressure; serum myoglobin levels; crush/ischemia injury;
   acute renal failure
ID ACUTE-RENAL-FAILURE; VACUUM-ASSISTED CLOSURE; CRUSH SYNDROME; WOUND
   CONTROL; REPERFUSION
AB Background: Patients with injuries that cause significant muscle death often develop rhabdomyolysis. The subsequent release and entry of myoglobin into the systemic circulation leads to myoglobinuria, renal injury, and potentially acute renal failure.
   Methods: Large (5 kg) adult rabbits (n = 8) were anesthetized and a 15-kg weight placed on the posterior compartment for 4 hours. After this time, the weight was removed and releasing incisions were made. Subatmospheric pressure (125 mm Hg) was continuously applied to the wounds of four rabbits. Systemic serum samples were obtained at the time of weight removal and at 2, 4, and 8 hours postremoval, and were analyzed for myoglobin content.
   Results: Serum myoglobin levels were similar for both groups at the time of weight removal. Serum myoglobin levels demonstrated a progressive increase with time in nontreated animals, and were significantly elevated compared with subatmospheric pressure-treated animals at all time points (p < 0.001).
   Conclusion: This study shows that application of subatmospheric pressure to an affected body part is associated with lower serum myoglobin levels.
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
   Wake Forest Univ, Sch Med, Dept Internal Med, Nephrol Sect, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest University
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM mmorykwa@wfubmc.edu
RI Molnar, Joseph/AEK-5540-2022
OI Morykwas, Michael/0009-0001-5547-5172
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 25
TC 34
Z9 42
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD SEP
PY 2002
VL 53
IS 3
BP 537
EP 540
DI 10.1097/00005373-200209000-00023
PG 4
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 599GA
UT WOS:000178324700031
PM 12352493
DA 2026-07-24
ER
PT J
AU Hynes, PJ
   Earley, MJ
   Lawlor, D
AF Hynes, PJ
   Earley, MJ
   Lawlor, D
TI Split-thickness skin grafts and negative-pressure dressings in the
   treatment of axillary hidradenitis suppurativa
SO BRITISH JOURNAL OF PLASTIC SURGERY
LA English
DT Article
DE axillary skin defect; split-thickness skin graft; negative-pressure
   dressing; hidradenitis suppurativa
ID VACUUM-ASSISTED CLOSURE; SURGICAL-TREATMENT; WOUND CONTROL; FLAP
AB Although a number of different reconstructive techniques have been described for the treatment of axillary skin defects, split-thickness skin grafting continues to be the most common surgical modality. Here, we present our recent experience of using split-thickness skin grafts together with negative-pressure dressings for the management of defects following wide surgical excision of severe hidradenitis suppurativa. This technique ensures complete skin-graft take whilst allowing full shoulder mobility, thereby minimising the undesirable sequelae associated with split-thickness skin grafting alone. (C) 2002 The British Association of Plastic Surgeons.
C1 Mater Misericordiae Hosp, Dept Plast & Reconstruct Surg, Dublin 7, Ireland.
C3 Mater Misericordiae University Hospital; University College Dublin
RP Hynes, PJ (通讯作者)，Mater Misericordiae Hosp, Dept Plast & Reconstruct Surg, Eccles St, Dublin 7, Ireland.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BANERJEE AK, 1992, BRIT J SURG, V79, P863, DOI 10.1002/bjs.1800790905
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   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
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   Soldin MG, 2000, BRIT J PLAST SURG, V53, P434, DOI 10.1054/bjps.1999.3285
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NR 12
TC 40
Z9 43
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0007-1226
J9 BRIT J PLAST SURG
JI Br. J. Plast. Surg.
PD SEP
PY 2002
VL 55
IS 6
BP 507
EP 509
DI 10.1054/bjps.2002.3899
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 601RW
UT WOS:000178462600009
PM 12479426
DA 2026-07-24
ER
PT J
AU Chester, DL
   Waters, R
AF Chester, DL
   Waters, R
TI Adverse alteration of wound flora with topical negative-pressure
   therapy: a case report
SO BRITISH JOURNAL OF PLASTIC SURGERY
LA English
DT Article
DE topical negative pressure; anaerobes; wound infection; inguinal block
   dissection
ID VACUUM-ASSISTED CLOSURE; DRESSINGS; PROMOTE
AB Topical negative pressure (TNP) has achieved widespread use in the treatment of problematic wounds. We report the case of a patient treated with TNP for Groin-wound dehiscence following inguinal block dissection. During treatment, clinical signs of sepsis developed, in association with a progressively worsening anaerobic wound infection. This infection settled with antibiotic therapy and cessation of TNP treatment. We postulate that the air-free environment created by TNP potentiated the Growth of the anaerobic bacteria, resulting in significant sepsis, and therefore recommend close surveillance of bacterial flora while using this therapy, particularly in susceptible patients. (C) 2002 The British Association of Plastic Surgeons.
C1 Univ Hosp Birmingham, Selly Oak Hosp, NHS Trust, Dept Plast Surg, Birmingham B29 6JD, W Midlands, England.
C3 University of Birmingham
RP Chester, DL (通讯作者)，Univ Hosp Birmingham, Selly Oak Hosp, NHS Trust, Dept Plast Surg, Raddlebarn Rd,Selly Oak, Birmingham B29 6JD, W Midlands, England.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P, 1998, BRIT J PLAST SURG, V51, P79, DOI 10.1016/S0007-1226(98)80142-2
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Elwood ET, 2001, ANN PLAS SURG, V46, P49, DOI 10.1097/00000637-200101000-00010
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Gwan-Nulla DN, 2001, ANN PLAS SURG, V47, P552, DOI 10.1097/00000637-200111000-00014
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
NR 8
TC 39
Z9 52
U1 0
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0007-1226
J9 BRIT J PLAST SURG
JI Br. J. Plast. Surg.
PD SEP
PY 2002
VL 55
IS 6
BP 510
EP 511
DI 10.1054/bjps.2002.3890
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 601RW
UT WOS:000178462600010
PM 12479427
OA Bronze
DA 2026-07-24
ER
PT J
AU Clare, MP
   Fitzgibbons, TC
   McMullen, ST
   Stice, RC
   Hayes, DF
   Henkel, L
AF Clare, MP
   Fitzgibbons, TC
   McMullen, ST
   Stice, RC
   Hayes, DF
   Henkel, L
TI Experience with the vacuum assisted closure negative pressure technique
   in the treatment of non-healing diabetic and dysvascular wounds
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
ID NEUROPATHIC FOOT ULCERS; TOTAL CONTACT CASTS; DEBRIDEMENT
AB The purpose of this study is to report our experience with the Vacuum Assisted Closure (VAC) negative pressure technique in patients with non-healing wounds of the foot, ankle, and lower limb. We retrospectively reviewed 17 patients with non-healing wounds of the lower extremity who underwent treatment using the Vacuum Assisted Closure (VAC) device. Thirteen of 17 (76%) had diabetes mellitus, nine of whom were insulin-dependent, and 10 of whom had associated peripheral neuropathy. Eight of 17 (47%) had severe peripheral vascular disease. All had failed previous management with serial wound debridements and dressing changes; 15 of 17 (88%) had previously completed at least one course of oral antibiotics. Thirteen of 17 (76%) had previously undergone operative irrigation and debridement of the wounds; six of 17 (35%) had previously undergone revascularization procedures of the involved extremity. Five of 17 (29%) had wounds necessitating an amputation procedure prior to the present treatment; seven of 17 (41%) had failed treatment with local growth factors prior to the present treatment. Average length of treatment with the VAC device was 8.2 weeks. Fourteen of 17 (82%) wounds successfully healed; four underwent split-thickness skin grafting for wound closure; four were briefly treated with local growth factors; six were treated with only dressing changes following VAC treatment. Three of 17 (18%) wounds failed VAC treatment; all three patients had diabetes and had wounds located in the midfoot or forefoot; two of three had severe peripheral vascular disease. Our results indicate that the Vacuum Assisted Closure negative pressure technique is emerging as an acceptable option for wound care of the lower extremity. Not all patients are candidates for such treatment; those patients with severe peripheral vascular disease or smaller forefoot wounds may be best treated by other modalities. Larger wounds seem to be better suited for skin grafting or two-stage primary closure.
C1 Gross Iwerson Kratochvil & Klein, Omaha, NE 68124 USA.
RP Fitzgibbons, TC (通讯作者)，Gross Iwerson Kratochvil & Klein, 7710 Mercy Rd,Suite 224, Omaha, NE 68124 USA.
EM drfitz@GIKK.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Steed DL, 1996, J AM COLL SURGEONS, V183, P61
NR 17
TC 96
Z9 121
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD OCT
PY 2002
VL 23
IS 10
BP 896
EP 901
DI 10.1177/107110070202301002
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 603PH
UT WOS:000178568000002
PM 12398140
DA 2026-07-24
ER
PT J
AU Heugel, JR
   Parks, KS
   Christie, SS
   Pulito, JF
   Zegzula, DH
   Kemalyan, NA
AF Heugel, JR
   Parks, KS
   Christie, SS
   Pulito, JF
   Zegzula, DH
   Kemalyan, NA
TI Treatment of the exposed Achilles tendon using negative pressure wound
   therapy: A case report
SO JOURNAL OF BURN CARE & REHABILITATION
LA English
DT Article; Proceedings Paper
CT Meeting of the American-College-of-Surgeons
CY SEP, 2001
CL SUN RIVER, OR
SP Amer Coll Surg
ID VACUUM-ASSISTED CLOSURE; FOREARM FREE-FLAP; RECONSTRUCTION; SKIN; SOFT;
   COMPLICATIONS; COVERAGE; DEFECTS; GRAFTS; STRESS
AB Exposed tendons after burn injury create a surgical challenge for the treating physician. This is particularly true with regard to the exposed Achilles tendon. This case report reviews the nature of this challenge and traditional solutions, and describes the use of negative pressure wound therapy to facilitate coverage of the Achilles tendon. This therapy may provide a more appropriate therapeutic option for dealing with tendon exposure after severe burns.
C1 Legacy Emanuel Hosp, Oregon Burn Ctr, Portland, OR USA.
RP Kemalyan, NA (通讯作者)，Oregon Burn Ctr, 2801 N Gantenbein Ave, Portland, OR 97227 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Ballard K, 2000, Br J Nurs, V9, P405
   BALLARD K, 2000, BR J NURS, V9, P12
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   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   BOWEN V, 1993, MICROSURG, V14, P196, DOI 10.1002/micr.1920140311
   Deiler S, 2000, PLAST RECONSTR SURG, V106, P342, DOI 10.1097/00006534-200008000-00016
   del Piñal F, 2000, PLAST RECONSTR SURG, V105, P1347, DOI 10.1097/00006534-200004040-00013
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
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   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P249, DOI 10.1097/00003086-198901000-00038
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   Mendez-Eastman S, 1998, RN, V61, P20
   Mendez-Eastman S, 1998, PLAST SURG NURS, V18, P33
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   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Stanec S, 1999, PLAST RECONSTR SURG, V104, P1409, DOI 10.1097/00006534-199910000-00026
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NR 26
TC 24
Z9 37
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0273-8481
J9 J BURN CARE REHABIL
JI J. Burn Care Rehabil.
PD MAY-JUN
PY 2002
VL 23
IS 3
BP 167
EP 171
DI 10.1097/00004630-200205000-00005
PG 5
WC Emergency Medicine; Rehabilitation; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Emergency Medicine; Rehabilitation; Surgery
GA 606ZF
UT WOS:000178765400002
PM 12032366
DA 2026-07-24
ER
PT J
AU Fleck, TM
   Fleck, M
   Moidl, R
   Czerny, M
   Koller, R
   Giovanoli, P
   Hiesmayer, MJ
   Zimpfer, D
   Wolner, E
   Grabenwoger, M
AF Fleck, TM
   Fleck, M
   Moidl, R
   Czerny, M
   Koller, R
   Giovanoli, P
   Hiesmayer, MJ
   Zimpfer, D
   Wolner, E
   Grabenwoger, M
TI The vacuum-assisted closure system for the treatment of deep sternal
   wound infections after cardiac surgery
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID MUSCLE FLAPS; RATIONAL APPROACH; STERNOTOMY; MEDIASTINITIS; MANAGEMENT;
   DIFFICULTIES; EXPERIENCE; DEVICE
AB Background. The VAC system (vacuum-assisted wound closure) is a noninvasive active therapy to promote healing in difficult wounds that fail to respond to established treatment modalities. The system is based on the application of negative pressure by controlled suction to the wound surface. The method was introduced into clinical practice in 1996. Since then, numerous studies proved the effectiveness of the VAC System on microcirculation and the promotion of granulation tissue proliferation.
   Methods. Eleven patients (5 men, 6 women) with a median age of 64.4 years (range 50 to 78 years) with sternal wound infection after cardiac surgery (coronary artery bypass grafting = 5, aortic valve replacement = 5, ascending aortic replacement = 1) were fitted with the VAC system by the time of initial surgical debridement.
   Results. Complete healing was achieved in all patients. The VAC system was removed after a mean of 9.3 days (range 4 to 15 days), when systemic signs of infection resolved and quantitative cultures were negative. In 6 patients (54.5%), the VAC system was used as a bridge to reconstructive surgery with a pectoralis muscle flap, and in the remaining 5 patients (45.5%), primary wound closure could be achieved. Intensive care unit stay ranged from 1 to 4 days (median 1 day). Duration of hospital stay varied from 13 to 45 days (median 30 days). In-hospital mortality was 0%, and 30-day survival was 100%.
   Conclusions. The VAC system can be considered as an effective and safe adjunct to conventional and established treatment modalities for the therapy of sternal wound infections after cardiac surgery. (C) 2002 by The Society of Thoracic Surgeons.
C1 Univ Vienna, AKH Vienna, Dept Cardiothorac Surg, A-1090 Vienna, Austria.
   Univ Vienna, Dept Plast & Reconstruct Surg, A-1090 Vienna, Austria.
C3 University of Vienna; University of Vienna
RP Fleck, TM (通讯作者)，Univ Vienna, AKH Vienna, Dept Cardiothorac Surg, Leitstelle 20A,Waehringer Guertel 18-20, A-1090 Vienna, Austria.
RI ; Zimpfer, Daniel/AAQ-9805-2021
OI Czerny, Martin/0000-0003-4766-9775; Zimpfer, Daniel/0000-0002-2185-4895
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Francel TJ, 2001, ANN THORAC SURG, V72, P1419, DOI 10.1016/S0003-4975(00)02009-9
   Harlan JW, 2002, PLAST RECONSTR SURG, V109, P710, DOI 10.1097/00006534-200202000-00045
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Hersh RE, 2001, HEART SURG FORUM, V4, P211
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Rand RP, 1998, ANN THORAC SURG, V65, P1046, DOI 10.1016/S0003-4975(98)00087-3
   SHUMACKER HB, 1963, ARCH SURG-CHICAGO, V86, P384
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
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NR 20
TC 123
Z9 143
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD NOV
PY 2002
VL 74
IS 5
BP 1596
EP 1600
AR PII S0003-4975(02)03948-6
DI 10.1016/S0003-4975(02)03948-6
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 615TG
UT WOS:000179262300035
PM 12440614
DA 2026-07-24
ER
PT J
AU Ramnarine, IR
   McLean, A
   Pollock, JCS
AF Ramnarine, IR
   McLean, A
   Pollock, JCS
TI Vacuum-assisted closure in the paediatric patient with post-cardiotomy
   mediastinitis
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE cardiac surgery; sternotomy infection; negative pressure therapy
AB Mediastinitis has a high mortality and is a major cause for concern in the neonatal cardiac surgical population. Vacuum-Assisted Closure (V.A.C.) is a newly established technique for expediting healing in the management of wounds resistant to established treatments; this includes the treatment of post-cardiotomy mediastinitis in the adult cardiac surgical patient. We describe the previously unreported use of the V.A.C. device for the successful treatment of post-cardiotomy mediastinitis in an infant. The device also improved the mechanics of respiration. We discuss potential risks and benefits of V.A.C. and suggest guidelines for its use. (C) 2002 Elsevier Science B.V. All rights reserved.
C1 Royal Hosp Sick Children, Glasgow G3 8SJ, Lanark, Scotland.
C3 University of Glasgow
RP Ramnarine, IR (通讯作者)，Royal Hosp Sick Children, Dalnair St, Glasgow G3 8SJ, Lanark, Scotland.
EM ianrramnarine@hotmail.com
OI Ramnarine, Ian/0000-0003-0161-3098
CR Berg HF, 2000, ANN THORAC SURG, V70, P924, DOI 10.1016/S0003-4975(00)01524-1
   Bucalo Brian, 1993, Wound Repair and Regeneration, V1, P181, DOI 10.1046/j.1524-475X.1993.10308.x
   Davydov Iu A, 1992, Khirurgiia (Mosk), P21
   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 7
TC 29
Z9 39
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD DEC
PY 2002
VL 22
IS 6
BP 1029
EP 1031
AR PII S1010-7940(02)00562-6
DI 10.1016/S1010-7940(02)00562-6
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 627LF
UT WOS:000179934100031
PM 12467837
OA Bronze
DA 2026-07-24
ER
PT J
AU Song, DH
   Wu, LC
   Lohman, RF
   Gottlieb, LJ
   Franczyk, M
AF Song, DH
   Wu, LC
   Lohman, RF
   Gottlieb, LJ
   Franczyk, M
TI Vacuum assisted closure for the treatment of sternal wounds: The bridge
   between debridement and definitive closure
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 70th Annual Meeting of the ASPS/PSEF/ASMS
CY NOV 03-07, 2001
CL ORLANDO, FLORIDA
SP ASPS, PSEF, ASMS
ID MUSCLE FLAPS; STERNOTOMY; MEDIASTINITIS; EXPERIENCE; MANAGEMENT
AB A method to refine the treatment of sternal wounds using Vacuum Assisted Closure (V.A.C.) therapy as the bridge between debridement and delayed definitive closure is described. A retrospective review of 35 consecutive patients with sternal wound complications over a 2-year period (March of 1999 to March of 2001) was performed. The treatment of sternal wounds with traditional twice-a-day dressing changes was compared with the treatment with the wound V.A.C. device. An analysis of the number of days between initial debridement aid closure, number of dressing changes, number and types, of flaps needed for reconstruction, and complications was performed. Eighteen patients were treated with traditional twice-a-day dressing changes and 17 patients were treated with V.A.C. therapy alone. The two groups were similar regarding age, sex, type of cardiac procedure, and tape of sternal wound. The V.A.C. therapy group had a trend toward a shorter interval between debridement and closure, with a mean of 6.2 days, whereas die dressing change group had mean of 8.5 days. The V.A.C. therapy group had a significantly lower number of dressing changes, with a mean of three, whereas the twice-a-day dressing change group had a mean of 17 (p < 0.05). Reconstruction required an average of 1.5 soft-tissue flaps per patient treated with traditional dressing changes versus 0.9 soft-tissue flaps per patient for those treated with V.A.C. therapy (p < 0.05). Before closure, there was one death among patients undergoing dressing changes and three in the V.A.C. therapy group, all of which were unrelated to the management of the sternal wound. Patients with sternal wounds who have benefited from V.A.C. therapy alone have a significant decrease in the number of dressing changes and number of soft-tissue flaps needed for closure. Finally, the V.A.C. therapy group had a trend toward a decreased number of days between debridement and closure.
C1 Univ Chicago Hosp, Plast & Reconstruct Surg Sect, Chicago, IL 60637 USA.
   Univ Chicago Hosp, Dept Phys Therapy, Chicago, IL 60637 USA.
C3 University of Chicago; University of Chicago Medical Center; University
   of Illinois System; University of Illinois System; University of
   Chicago; University of Chicago Medical Center
RP Song, DH (通讯作者)，Univ Chicago Hosp, Plast & Reconstruct Surg Sect, 5841 S Maryland Ave,MC 6035, Chicago, IL 60637 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   GOTTLIEB LJ, 1994, ARCH SURG-CHICAGO, V129, P489
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Jones G, 1997, ANN SURG, V225, P766, DOI 10.1097/00000658-199706000-00014
   JURKIEWICZ MJ, 1980, ANN SURG, V191, P738, DOI 10.1097/00000658-198006000-00012
   MAJURE JA, 1986, ANN THORAC SURG, V42, P9, DOI 10.1016/S0003-4975(10)61825-5
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   NAHAI F, 1989, PLAST RECONSTR SURG, V84, P434, DOI 10.1097/00006534-198909000-00009
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
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NR 13
TC 120
Z9 136
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2003
VL 111
IS 1
BP 92
EP 97
DI 10.1097/01.PRS.0000037686.14278.6A
PG 6
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 631WY
UT WOS:000180191700014
PM 12496568
DA 2026-07-24
ER
PT J
AU Wanner, MB
   Schwarzl, F
   Strub, B
   Zaech, GA
   Pierer, G
AF Wanner, MB
   Schwarzl, F
   Strub, B
   Zaech, GA
   Pierer, G
TI Vacuum-assisted wound closure for cheaper and more comfortable healing
   of pressure sores: A prospective study
SO SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND
   SURGERY
LA English
DT Article
DE vacuum treatment; pressure sores; wound healing
ID SEALING TECHNIQUE; ULCERS
AB Pressure sores are a common complication of patients with spinal injuries. The vacuum-assisted closure technique is widely used to induce and promote wound healing. We tested our clinical impression that pressure sores healed faster with vacuum-assisted closure, and compared it with the traditional wet-to-dry/wet-to-wet technique with gauze soaked in Ringer's solution changed three times a day. Consecutive patients with pressure sores were entered into the study. Two randomised groups of 11 patients each with pressure sores of the pelvic region were included. We found no difference in time to reach 50% of the initial wound volume between the two methods. The vacuum-assisted group took a mean (SD) of 27 (10) days and the traditional group 28 (7) days. The two methods were equally effective in forming granulation tissue, so one can profit from the other advantages of the vacuum-assisted treatment (reduced costs and improved comfort) knowing that the effect on the formation of granulation tissue is as good as with the traditional treatment.
C1 Swiss Parapleg Ctr, CH-6207 Nottwil, Switzerland.
   Univ Basel Hosp, Clin Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
C3 Swiss Paraplegic Research; University of Basel
RP Wanner, MB (通讯作者)，Swiss Parapleg Ctr, CH-6207 Nottwil, Switzerland.
EM marcus.wanner@paranet.ch
CR Allman R M, 1999, Adv Wound Care, V12, P22
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BARBENEL JC, 1977, LANCET, V2, P548
   BERG W, 1990, LANCET, V335, P1445, DOI 10.1016/0140-6736(90)91459-N
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   Daniel R K, 1979, Ann Plast Surg, V3, P53
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   Fleischmann W, 1997, UNFALLCHIRURG, V100, P301, DOI 10.1007/s001130050123
   HERZBERG G, 1987, HELV CHIR ACTA, V54, P421
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   SCHWARZL F, 1998, ACTA CHIRURG AUSTR S, V150, P8
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NR 19
TC 104
Z9 114
U1 0
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0284-4311
J9 SCAND J PLAST RECONS
JI Scand. J. Plast. Reconstr. Surg. Hand Surg.
PY 2003
VL 37
IS 1
BP 28
EP 33
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 645DR
UT WOS:000180961400006
PM 12625392
DA 2026-07-24
ER
PT J
AU McGuinness, JG
   Winter, DC
   O'Connell, PR
AF McGuinness, JG
   Winter, DC
   O'Connell, PR
TI Vacuum-assisted closure of a complex pilonidal sinus
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE pilonidal sinus; closure; vacuum-assisted
ID SUBATMOSPHERIC PRESSURE; WOUND CONTROL; COMPLICATIONS
AB INTRODUCTION: The annual incidence of pilonidal sinus is approximately 26 per 100,000, of which complex pilonidal sinuses are the minority. Many different approaches have been described for managing simple cases. Treatment options for complex pilonidal sinus include excision with healing by secondary intention or plastic surgical procedures to obliterate the defect. Recently, vacuum-assisted closure has been used by plastic surgeons to facilitate healing of chronic or complicated,wounds with particular success in treating pressure wounds overlying the sacrum. METHODS: A patient with a complex pilonidal sinus was managed with excision and vacuum-assisted closure. RESULTS: A large tissue defect after radical excision healed relatively quickly when the subatmospheric pressure dressing was applied. The patient was discharged with the vacuum pump and change of dressings for alternate days. CONCLUSION: Vacuum-assisted closure of a complex pilonidal sinus shortened the length of hospital stay and the need for further surgery and provided a cosmetically acceptable result.
C1 Univ Coll Dublin, Mater Misericordiae Hosp, Dept Surg, Dublin 7, Ireland.
C3 University College Dublin; Mater Misericordiae University Hospital
RP O'Connell, PR (通讯作者)，Univ Coll Dublin, Mater Misericordiae Hosp, Dept Surg, Dublin 7, Ireland.
RI O'Connell, P. Ronan/H-6583-2019
OI O'Connell, P. Ronan/0000-0002-1846-5629
CR ALLENMERSH TG, 1990, BRIT J SURG, V77, P123, DOI 10.1002/bjs.1800770203
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Berger A, 1995, ANN CHIR, V49, P889
   Cervelli V, 1997, Minerva Chir, V52, P659
   da Silva JH, 2000, DIS COLON RECTUM, V43, P1146
   Destito C, 1997, G Chir, V18, P441
   Fabian TS, 2000, AM SURGEON, V66, P1136
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Greer SE, 1999, ANN PLAS SURG, V43, P551, DOI 10.1097/00000637-199911000-00016
   Greer SE, 2001, ANN THORAC SURG, V71, P1038, DOI 10.1016/S0003-4975(00)02431-0
   GREER SE, ANN PLAST SURG, V45, P332
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Morykwas MJ, 1999, J BURN CARE REHABIL, V20, P15, DOI 10.1097/00004630-199901001-00003
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   SURRELL JA, 1994, SURG CLIN N AM, V74, P1309
NR 15
TC 48
Z9 60
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD FEB
PY 2003
VL 46
IS 2
BP 274
EP 276
DI 10.1007/s10350-004-6535-z
PG 3
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 646KB
UT WOS:000181033200019
PM 12576904
DA 2026-07-24
ER
PT J
AU Luckraz, H
   Murphy, F
   Bryant, S
   Charman, SC
   Ritchie, AJ
AF Luckraz, H
   Murphy, F
   Bryant, S
   Charman, SC
   Ritchie, AJ
TI Vacuum-assisted closure as a treatment modality for infections after
   cardiac surgery
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID POSTSTERNOTOMY MEDIASTINITIS; MANAGEMENT
AB Objective: Wound infections after cardiac surgery carry high morbidity and mortality. A plethora of management strategies have been used to treat such infections. We assessed the impact of vacuum-assisted closure on the management of sternal wound infections in terms of wound healing, duration of vacuum-assisted closure, and cost of treatment.
   Methods: Between November 1998 and June 2001, a total of 27 mediastinal infections were managed with vacuum-assisted closure. Group A (n = 14) had vacuum-assisted closure as the final treatment modality, whereas in group B (n = 13) vacuum-assisted closure was followed by either a myocutaneous flap (n = 8) or primary (n = 5) wound closure. The choice of additional treatment modality was based on wound size.
   Results: In group A, 4 patients died and a satisfactorily healed sear was achieved in 64% of cases. Median durations of vacuum-assisted closure and hospital stay in group A were 13.5 days (interquartile range 8.8-32.2 days) and 20 days (interquartile range 16.7-25.2 days), respectively. Mortality was 7.7% in group B, with a treatment failure rate of 15%. Median duration of vacuum-assisted closure in group B was 8 days (interquartile range 5.5-18 days), and median hospital stay was 29 days (interquartile range 25.8-38.2 days). During the year before institution of vacuum-assisted closure, poststernotomy infection (n = 13) was managed with rewiring and closed irrigation system. Treatment during this year failed in 30.7% of cases (n = 4/13), and mortality was also 30.7%. The total cost (hospitalization and treatment) per patient for vacuum-assisted closure was $16,400, compared with $20,000 for the closed irrigation system treatment.
   Conclusion: Vacuum-assisted closure, used alone or before other surgical treatment strategies, is an acceptable treatment modality for infections in cardiac surgery with reasonable morbidity, mortality, and cost.
C1 Papworth Hosp, Cardiothorac Surg Unit, Cambridge CB3 8RE, England.
   MRC, Biostat Unit, Cambridge CB2 2BW, England.
C3 Papworth Hospital; MRC Biostatistics Unit
RP Luckraz, H (通讯作者)，Papworth Hosp, Cardiothorac Surg Unit, Cambridge CB3 8RE, England.
RI ; Luckraz, Heyman/AAV-7206-2020
OI Downie, Fiona/0009-0008-5892-3648; Luckraz, Heyman/0000-0003-1218-1243
CR Banwell P E, 1999, J Wound Care, V8, P79
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NR 13
TC 77
Z9 89
U1 0
U2 4
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0022-5223
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD FEB
PY 2003
VL 125
IS 2
BP 301
EP 305
DI 10.1067/mtc.2003.74
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 647NY
UT WOS:000181100800011
PM 12579098
OA Bronze
DA 2026-07-24
ER
PT J
AU Isago, T
   Nozaki, M
   Kikuchi, Y
   Honda, T
   Nakazawa, H
AF Isago, T
   Nozaki, M
   Kikuchi, Y
   Honda, T
   Nakazawa, H
TI Negative-pressure dressings in the treatment of pressure ulcers
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE negative pressure dressings; negative pressure therapy; pressure ulcers;
   healing index; skin ulcers
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; STRESS
AB Applying negative pressure to wounds may speed the formation of granulation tissue, decrease the amount of localized edema, increase blood flow, and accelerate healing. In the present study, we treated ten patients with stage IV chronic pressure ulcers using this negative pressure dressing technique. The long (A) and short (B) diameters of each ulcer were measured to determine size, and the vertical distance from the skin to the deepest point of the ulcer was measured to determine depth. Lesions were measured initially and at weekly intervals. The area of each lesion was taken to be 3.14 x A/2 x B/2 (cm(2)). When we compared the area of ulcer before and after the treatment, the area had been reduced in all cases, and the average reduction was 55.1%. The depth of ulcer also decreased in all cases, and the average reduction was 61.2%. Over the period of evaluation, the method was considered markedly effective in reducing the size and depth of ulcers.
C1 Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, Tokyo 1628666, Japan.
   Natl Disaster Med Ctr, Dept Plast & Reconstruct Surg, Tokyo, Japan.
C3 Tokyo Women's Medical University
RP Isago, T (通讯作者)，Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BAUCHEN IA, 1982, BURNS, V8, P39
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   DALTREY DC, 1981, J CLIN PATHOL, V34, P701, DOI 10.1136/jcp.34.7.701
   Elwood ET, 2001, ANN PLAS SURG, V46, P49, DOI 10.1097/00000637-200101000-00010
   FALANGA V, 1988, ARCH DERMATOL, V124, P872, DOI 10.1001/archderm.124.6.872
   Falanga Vincent, 1992, Journal of Dermatology (Tokyo), V19, P667
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   GILCHRIST B, 1989, BRIT J DERMATOL, V121, P337, DOI 10.1111/j.1365-2133.1989.tb01427.x
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P249, DOI 10.1097/00003086-198901000-00038
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P263
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NR 19
TC 17
Z9 27
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD APR
PY 2003
VL 30
IS 4
BP 299
EP 305
DI 10.1111/j.1346-8138.2003.tb00391.x
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 672RD
UT WOS:000182534500003
PM 12707466
DA 2026-07-24
ER
PT J
AU Hallberg, H
   Holmström, H
AF Hallberg, H
   Holmström, H
TI Vaginal construction with skin grafts and vacuum-assisted closure
SO SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND
   SURGERY
LA English
DT Article
DE congenital absence of the vagina; neovagina; vaginal construction;
   vacuum assisted closure; VAC
AB Probably the most common method of constructing a vagina in patients with the Mayer-Rokitansky-Kuster syndrome is the technique popularised by McIndoe and Banister in 1938. A cavity is created between the rectum and urethra-bladder complex and is lined with split-thickness skin grafts. One of the disadvantages of using split-thickness skin grafts is the incidence of late contraction of the neovagina. To avoid this problem full-thickness skin grafts have been used, but their take is less reliable. A new technique to improve the take of skin grafts is the VAC-system (vacuum assisted closure, KCI(R)) which has proved to be particularly valuable in grafting difficult anatomical sites. We have used the VAC-system in the construction of a vagina in one case with split-thickness skin grafts and in two cases with full-thickness skin grafts. In all three cases the take was excellent with little discomfort for the patients. It was not necessary to stent the neovagina in the postoperative period and coitus was possible within a month of operation.
C1 Univ Gothenburg, Sahlgrens Univ Hosp, Dept Plast Surg, SE-41345 Gothenburg, Sweden.
C3 Sahlgrenska University Hospital; University of Gothenburg
RP Holmström, H (通讯作者)，Univ Gothenburg, Sahlgrens Univ Hosp, Dept Plast Surg, SE-41345 Gothenburg, Sweden.
CR Abbe R., 1898, Med. Rec, V54, P836
   HOLMSTROM H, 1976, SCAND J PLAST RECONS, V10, P231, DOI 10.3109/02844317609012974
   McIndoe A H., 1938, J Obstet Gynecol Br Emp, V45, P490, DOI [DOI 10.1111/J.1471-0528.1938.TB11141.X, 10.1111/j.1471-0528.1938.tb11141.x]
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   SADOVE RC, 1988, CLIN PLAST SURG, V15, P443
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
NR 6
TC 25
Z9 32
U1 0
U2 2
PU TAYLOR & FRANCIS AS
PI OSLO
PA CORT ADELERSGT 17, PO BOX 2562, SOLLI, 0202 OSLO, NORWAY
SN 0284-4311
J9 SCAND J PLAST RECONS
JI Scand. J. Plast. Reconstr. Surg. Hand Surg.
PY 2003
VL 37
IS 2
BP 97
EP 101
DI 10.1080/02844310310005621
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 672RV
UT WOS:000182536000006
PM 12755509
DA 2026-07-24
ER
PT J
AU Schipper, J
   Ridder, GJ
   Maier, W
   Horch, RE
AF Schipper, J
   Ridder, GJ
   Maier, W
   Horch, RE
TI The preconditioning and prelamination of pedicled and free microvascular
   anastomised flaps with the technique of vacuum assisted closure
SO LARYNGO-RHINO-OTOLOGIE
LA German
DT Article; Proceedings Paper
CT 46th Austrian HNO Congress
CY SEP 18-22, 2002
CL FLEDKIRCH, AUSTRIA
DE atmospheric pressure; granulation tissue; wound healing;
   neovascularization; surgical flaps
ID SUBATMOSPHERIC PRESSURE; CLINICAL IMPLICATIONS; WOUND CONTROL;
   ANGIOSOMES; THERAPY; ULCERS; BODY
AB Background: Since the technique of vacuum assisted closure has been clinically introduced, the possibilities in reconstructive head and neck surgery have greatly increased. Preconditioning and prelaminating allows a pedicled or free flap plasty to be epithelialized on both sides before the flap gets transferred to its future location. Methods: We describe the technique of preconditioning and prelaminating of pedicled and free microvascular anastomised flap plasties and we report our experience with 5 cases. Our results are compared with data from the literature. Results: The procedures concerned take only little time and the flap gets optimally prepared for its task in view of the postoperatively modified hemodynamics. By preconditioning, the flap to be lifted is prepared for the future centralised blood supply exclusively via the pedicle vessel without leaving the donor side. Thereby the skin island of such flaps can be increased in size over the natural angiosomes without an increased risk of necrotisation. Conclusions: By the technique of prelamination, skin or mucosa tissue may be applied onto both sides of the flap so that it can resist the biochemical and mechanical tasks which will be required after transposition. Especially for the reconstruction of defects in the upper aerodigestive tract this is a great advantage, since the inner side of the flap has to resist saliva which represents one of the most aggressive secretions in the human body.
C1 Univ Freiburg Klinikum, Univ Klin Hals Nasen & Ohrenheilkunde & Poliklin, D-79106 Freiburg, Germany.
   Univ Freiburg Klinikum, Chirurg Univ Klin, Abt Plast & Handchirurg, D-79106 Freiburg, Germany.
C3 University of Freiburg; University of Freiburg
RP Schipper, J (通讯作者)，Univ Freiburg Klinikum, Univ Klin Hals Nasen & Ohrenheilkunde & Poliklin, D-79106 Freiburg, Germany.
EM schipper@hno.ukl.uni-freiburg.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353; Ridder, Gerd J/0000-0002-9742-4437
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NR 31
TC 18
Z9 18
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0935-8943
EI 1438-8685
J9 LARYNGO RHINO OTOL
JI Laryngo-Rhino-Otol.
PD JUN
PY 2003
VL 82
IS 6
BP 421
EP 427
PG 7
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Otorhinolaryngology
GA 696YV
UT WOS:000183916100006
PM 12851850
DA 2026-07-24
ER
PT J
AU Hess, CL
   Howard, MA
   Attinger, CE
AF Hess, CL
   Howard, MA
   Attinger, CE
TI A review of mechanical adjuncts in wound healing: Hydrotherapy,
   ultrasound, negative pressure therapy, hyperbaric oxygen, and
   electrostimulation
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CLINICAL-TRIAL; DOUBLE-BLIND;
   ELECTRICAL-STIMULATION; SKIN ULCERS; ELECTROMAGNETIC-FIELDS; DOSE
   ULTRASOUND; VENOUS ORIGIN; HIGH-VOLTAGE; LEG ULCERS
AB Chronic or non-healing wounds may develop in the setting of many diseases and are the source of considerable morbidity as well as health costs. These wounds demand an aggressive, multifactorial approach including surgical debridement, revascularization, antibiotics and dressings. In addition serveral adjuvant treatment methods have been developed to further stimulate healing. Whirlpool, although used frequently, has not been proven to be of benefit. However, pulsed lavage does show a promising future. Ultrasound has demonstrated beneficial effects but further controlled studies are needed. Subatmospheric pressure therapy is associated with few complications and is fast becoming a mainstay of adjuvant therapy. Hyperbaric oxygen therapy has been shown to be effective for many types of wounds. Unfortunately, cost and access to chambers may prohibit its use on a routine basis. Finally, electrostimulation may be one of the up and coming therapies for the future. Though, more studies are needed to determine the mode of delivery for various types of wounds.
C1 Georgetown Univ Hosp, Div Plast Surg, Washington, DC 20007 USA.
C3 Georgetown University
RP Hess, CL (通讯作者)，3800 Reservoir Rd NW,1st Floor,PHC Bldg, Washington, DC 20007 USA.
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NR 81
TC 99
Z9 122
U1 0
U2 38
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD AUG
PY 2003
VL 51
IS 2
BP 210
EP 218
DI 10.1097/01.SAP.0000058513.10033.6B
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 714LN
UT WOS:000184915900018
PM 12897528
DA 2026-07-24
ER
PT J
AU Isago, T
   Nozaki, M
   Kikuchi, Y
   Honda, T
   Nakazawa, H
AF Isago, T
   Nozaki, M
   Kikuchi, Y
   Honda, T
   Nakazawa, H
TI Effects of different negative pressures on reduction of wounds in
   negative pressure dressings
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE negative pressure dressings; negative pressure therapy; negative
   pressure levels; animal study
ID VACUUM-ASSISTED CLOSURE; STRESS
AB Negative pressure dressings stimulate the healing of tissue-deficient wounds by applying continuous or intermittent negative pressure. This study was designed to determine the most effective negative pressure level for the reduction of the wound by using negative pressure dressings in animal studies. Fifty male Wister rats weighting 200-250 grams were used throughout the study. The animals were divided into five groups of ten animals each as follows: group 1: No negative pressure and a closed dressing method using a polyurethane foam and an adhesive drape. Group 2-5: 25, 50, 75 and 125 mmHg negative pressure and a closed dressing method using a polyurethane foam and an adhesive drape. The wounds were measured along the vertical and horizontal lengths of the body axis and the wound area was calculated. The reduction of the wound area was weaker in the group with a negative pressure of 25 mmHg, and similarly higher among the groups with negative pressures of 50, 75, or 125 mmHg. There were no significant differences in the reduction of the wound area among the latter three groups.
C1 Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, Tokyo 1628666, Japan.
   Natl Disaster Med Ctr, Dept Plast & Reconstruct Surg, Tokyo, Japan.
C3 Tokyo Women's Medical University
RP Isago, T (通讯作者)，Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P249, DOI 10.1097/00003086-198901000-00038
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P263
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   OLENIUS M, 1993, PLAST RECONSTR SURG, V91, P213, DOI 10.1097/00006534-199302000-00001
   REULER JB, 1981, ANN INTERN MED, V94, P661, DOI 10.7326/0003-4819-94-5-661
   URSCHEL JD, 1988, BRIT J PLAST SURG, V41, P182, DOI 10.1016/0007-1226(88)90049-5
   WITKOWSKI JA, 1982, J AM ACAD DERMATOL, V6, P1014, DOI 10.1016/S0190-9622(82)70085-4
NR 9
TC 44
Z9 54
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD AUG
PY 2003
VL 30
IS 8
BP 596
EP 601
DI 10.1111/j.1346-8138.2003.tb00441.x
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 714LY
UT WOS:000184916800003
PM 12928528
DA 2026-07-24
ER
PT J
AU Domkowski, PW
   Smith, ML
   Gonyon, DL
   Drye, C
   Wooten, MK
   Levin, LS
   Wolfe, WG
AF Domkowski, PW
   Smith, ML
   Gonyon, DL
   Drye, C
   Wooten, MK
   Levin, LS
   Wolfe, WG
TI Evaluation of vacuum-assisted closure in the treatment of poststernotomy
   mediastinitis
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID WOUND-INFECTION; RISK-FACTORS; SURGERY
AB Objective: Poststemotomy mediastinitis, although infrequent, is a potentially life-threatening complication of cardiac surgery that continues to have a significant morbidity and mortality despite aggressive therapy. Vacuum-assisted closure uses controlled suction to provide evacuation of wound fluid, decrease bacterial colonization, stimulate granulation tissue, and reduce the need for dressing changes.
   Methods: One hundred two patients from Duke University Hospital, The Durham Veterans Administration Hospital, and referring institutions underwent vacuum-assisted closure treatment. There were 63 men and 39 women, with a mean age of 67. The infection was noticed between postoperative days 8 and 34, at which time the wounds were opened and debrided.
   Results: Ninety-six of the 102 patients received vacuum-assisted therapy while the remaining 6 underwent daily multiple dressing changes without vacuum-assisted therapy. Fifty-three-of the 96 patients required only sternal debridement, followed by wound vacuum therapy and closure by secondary intention, while the remaining 43 had an additional procedure. Of these, 33 patients underwent omental transposition and 10 patients had a pectoralis flap. The length of stay for all patients was 27 +/- 12 days. This was related in part to intravenous antibiotics. Hospital mortality for all patients was 3.7% (4 patients). Two of these patients underwent vascular flap and succumbed to multisystemic organ failure, while the other 2 received only wound vacuum therapy following debridement and succumbed to overwhelming sepsis.
   Conclusion: Vacuum-assisted drainage is an effective therapy for mediastinitis following debribement or before placement of a vascularized tissue flap.
C1 Duke Univ, Med Ctr, Div Cardiovasc & Thorac Surg, Dept Surg, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Div Plast Surg, Durham, NC 27710 USA.
   Durham Vet Hosp, Dept Surg, Durham, NC USA.
C3 Duke University; Duke University
RP Wolfe, WG (通讯作者)，Duke Univ, Med Ctr, Div Cardiovasc & Thorac Surg, Dept Surg, Box 3507, Durham, NC 27710 USA.
CR Berg HF, 2000, ANN THORAC SURG, V70, P924, DOI 10.1016/S0003-4975(00)01524-1
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Kirsch M, 2001, ANN THORAC SURG, V71, P1580, DOI 10.1016/S0003-4975(01)02452-3
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Mendez-Eastman S, 1999, J Wound Ostomy Continence Nurs, V26, P67, DOI 10.1016/S1071-5754(99)90017-7
   Milano CA, 1999, ANN THORAC SURG, V67, P377, DOI 10.1016/S0003-4975(99)00022-3
   MILANO CA, 1995, CIRCULATION, V92, P2245, DOI 10.1161/01.CIR.92.8.2245
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   PAYNE WS, 1969, SURG CLIN N AM, V49, P999
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NR 13
TC 93
Z9 125
U1 0
U2 3
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0022-5223
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD AUG
PY 2003
VL 126
IS 2
BP 386
EP 390
DI 10.1016/S0022-5223(03)00352-0
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 715UZ
UT WOS:000184991800016
PM 12928634
OA Bronze
DA 2026-07-24
ER
PT J
AU Wongworawat, MD
   Schnall, SB
   Holtom, PD
   Moon, C
   Schiller, F
AF Wongworawat, MD
   Schnall, SB
   Holtom, PD
   Moon, C
   Schiller, F
TI Negative pressure dressings as an alternative technique for the
   treatment of infected wounds
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article; Proceedings Paper
CT 12th Annual Meeting of the Musculoskeletal-Infection-Society
CY AUG 01-03, 2002
CL ASPEN, COLORADO
SP Musculoskeletal Infect Soc
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; TISSUE DEFECTS; EXPERIENCE;
   SYSTEM; DEVICE
AB Coverage of wounds caused by infection and subsequent treatment often are variable because of the location of the wound and wound size. Although much research has been done to expand the indications of negative pressure wound treatment systems, little investigation has been done to quantify the reduction of wound size for vacuum-assisted closure treatment in the presence of infection. In this series, 14 patients who had wounds caused by infections were treated with the vacuum-assisted wound closure system. All wounds were greater than 20 cm(2). The duration of treatment averaged 10 days (range, 2-27 days), and the initial wound size averaged 70 cm(2) (range, 22.5-288 cm(2)). After the course of treatment, the final wound size averaged 39 cm(2) (range, 10-147 cm(2)). The average wound size reduction was 43%. This method seems to enhance the rapidity of wound reduction, and because it is a closed system of treatment, it has the added benefit of minimizing exposure of staff and other patients to communicable diseases. Vacuum-assisted wound closure systems add another option in the care of musculoskeletal infections.
C1 Univ So Calif, Keck Sch Med, Dept Orthopaed Surg, Los Angeles, CA USA.
C3 University of Southern California
RP Schnall, SB (通讯作者)，2025 Zonal Ave,GNH 3900, Los Angeles, CA 90089 USA.
RI ; Wongworawat, Montri/I-6546-2019
OI Moon, Charles/0000-0003-3180-8320; Wongworawat,
   Montri/0000-0003-2530-5612
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Greer SE, 2000, ANN PLAS SURG, V45, P332, DOI 10.1097/00000637-200045030-00019
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Joseph E, 2000, WOUNDS, V12, P60
   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Schnall SB, 1997, CLIN ORTHOP RELAT R, P286
   SCOTT JC, 1952, J BONE JOINT SURG BR, V34, P581, DOI 10.1302/0301-620X.34B4.581
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   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 14
TC 36
Z9 49
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-921X
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD SEP
PY 2003
IS 414
BP 45
EP 48
DI 10.1097/01.blo.0000084400.53464.02
PG 4
WC Orthopedics; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 721XM
UT WOS:000185343800007
PM 12966275
DA 2026-07-24
ER
PT J
AU Herscovici, D
   Sanders, RW
   Scaduto, JM
   Infante, A
   DiPasquale, T
AF Herscovici, D
   Sanders, RW
   Scaduto, JM
   Infante, A
   DiPasquale, T
TI Vacuum-assisted wound closure (VAC therapy) for the management of
   patients with high-energy soft tissue injuries
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE fractures; wounds; vacuum-assisted closure
ID LATISSIMUS-DORSI FLAP; DONOR-SITE MORBIDITY; FLUID; FIBRONECTIN;
   DEFECTS; ULCERS
AB Objective: To evaluate the results of a vacuum-assisted closure device in patients presenting with open high-energy soft tissue injuries.
   Design: Consecutive nonrandomized clinical study.
   Setting/Participants: From August 1999 through October 2000, 21 patients, with 21 high-energy soft tissue wounds (6 tibial, 10 ankle, and 5 with wounds of the forearm, elbow, femur, pelvis, and a below-knee stump) were treated with a vacuum-assisted closure device at a Level 1 trauma center.
   Intervention: A negative atmospheric pressure device used for the management of complex open injuries. Infected wounds had dressings changed every 48 hours, whereas all others had dressings changed every 72 to 96 hours.
   Main Outcome Measurements: The duration of vacuum-assisted closure use, final wound closure outcome, costs versus standard dressing changes or free flaps, and a list of all complications were recorded. All patients were followed for 6 months postcoverage.
   Results: Patients averaged 4.1 sponge changes, 77% performed at bedside, with the device used an average of 19.3 days. Twelve wounds (57%) required either no further treatment or a split-thickness skin graft, and 9 (43%) required a free tissue transfer.
   Conclusions: The vacuum-assisted closure appears to be a viable adjunct for the treatment of open high-energy injuries. Application can be performed as a bedside procedure but additional soft tissue reconstruction may be needed for definitive coverage. This device does not replace the need for formal debridement of necrotic tissue, but it may avoid the need for a free tissue transfer in some patients with large traumatic wounds.
C1 Tampa Gen Hosp, Orthopaed Trauma Serv, Tampa, FL 33606 USA.
C3 Tampa General Hospital
RP Herscovici, D (通讯作者)，Florida Orthopaed Inst, 13020 N Telecom Pkwy, Temple Terrace, FL 33637 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baynham S A, 1999, Ostomy Wound Manage, V45, P28
   Blackwell KE, 1997, HEAD NECK-J SCI SPEC, V19, P620, DOI 10.1002/(SICI)1097-0347(199710)19:7<620::AID-HED10>3.3.CO;2-H
   Bucalo Brian, 1993, Wound Repair and Regeneration, V1, P181, DOI 10.1046/j.1524-475X.1993.10308.x
   DALTREY DC, 1981, J CLIN PATHOL, V34, P701, DOI 10.1136/jcp.34.7.701
   DEFANZO AJ, 1999, PLAST RECONSTR SURG, V104, P2145
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Falanga Vincent, 1992, Journal of Dermatology (Tokyo), V19, P667
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NR 25
TC 165
Z9 205
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2003
VL 17
IS 10
BP 683
EP 688
DI 10.1097/00005131-200311000-00004
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 742VJ
UT WOS:000186538500004
PM 14600567
DA 2026-07-24
ER
PT J
AU Dieu, T
   Leung, M
   Leong, J
   Morrison, W
   Cleland, H
   Archer, B
   Oppy, A
AF Dieu, T
   Leung, M
   Leong, J
   Morrison, W
   Cleland, H
   Archer, B
   Oppy, A
TI Too much vacuum-assisted closure
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE early reconstruction; prolonged application; vacuum-assisted closure
ID CLINICAL-EXPERIENCE; NEGATIVE-PRESSURE; WOUND CONTROL
AB There has been an explosion in the use of the vacuum-assisted closure device since 1997. Selectively and judiciously used, it is a valuable tool. However, we are concerned by the expanding list of 'indications' for its use. Prolonged applications, frequently several weeks, at the expense of early surgical reconstruction, might compromise the outcome in selected cases. We report four cases that illustrate this problem and stress the importance of timely surgical reconstruction utilizing the range of reconstructive techniques available as well as vacuum-assisted closure dressing.
C1 Alfred Hosp, Dept Plast & Reconstruct Surg, Melbourne, Vic, Australia.
   St Vincents Hosp, Dept Plast & Reconstruct Surg, Melbourne, Vic, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; St Vincent's Health; St Vincent's Hospital
   Melbourne; NSW Health; St Vincents Hospital Sydney
RP Dieu, T (通讯作者)，60 Bangalore St, Kensington, Vic 3031, Australia.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baxandall T, 1997, Elder Care, V9, P22
   Deva A K, 1997, J Wound Care, V6, P311
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   *KCI INT, 2001, VAC ASS WOUND HEAL B
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Strover AE, 1997, J ROY COLL SURG EDIN, V42, P119
   Wu SH, 2000, EUR J PLAST SURG, V23, P174, DOI 10.1007/s002380050243
NR 11
TC 9
Z9 17
U1 0
U2 0
PU BLACKWELL PUBLISHING ASIA
PI CARLTON
PA 54 UNIVERSITY ST, P O BOX 378, CARLTON, VICTORIA 3053, AUSTRALIA
SN 1445-1433
J9 ANZ J SURG
JI ANZ J. Surg.
PD DEC
PY 2003
VL 73
IS 12
BP 1057
EP 1060
DI 10.1046/j.1445-2197.2003.t01-10-.x
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 747JA
UT WOS:000186800400022
PM 14632906
DA 2026-07-24
ER
PT J
AU Gustafsson, RI
   Sjögren, J
   Ingemansson, R
AF Gustafsson, RI
   Sjögren, J
   Ingemansson, R
TI Deep sternal wound infection:: A sternal-sparing technique with
   vacuum-assisted closure therapy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID POSTOPERATIVE MEDIASTINITIS; CARDIAC-SURGERY; EXPERIENCE; STERNOTOMY;
   MANAGEMENT; SYSTEM; RECONSTRUCTION; FLAPS
AB Background. Vacuum-assisted closure therapy is a novel treatment employed to aid wound healing in different areas of the body and recently also in sternotomy wounds. Aggressive vacuum-assisted closure treatment of the sternum in postoperative deep wound infection enhances sternal preservation and the rate of possible rewiring.
   Methods. The records of 40 consecutive patients with deep sternal wound infection were reviewed. Sternal bone sparing was achieved by using layers of paraffin gauze (Jelonet; Smith and Nephew Medical, Hull, UK) at the bottom of the wound in order to cover and protect visible parts of the right ventricle, lung tissue, and grafts from the sternal edges. Two separate layers of polyurethane foam (KCI, Copenhagen, Denmark) were placed so as to fit between the sternal edges and subcutaneously. A continuous negative pressure of 125 mm Hg was applied and subsequent revision was made exclusively in non-granulation areas.
   Results. There were no deaths during the 90 days of follow-up. Three late deaths unrelated to the infection and three subcutaneous fistulas occurred during the total follow-up period (3 to 41 months). The median duration of the vacuum-assisted closure therapy was 10 days (range, 3 to 34). The series represents a total of 474 days with the vacuum-assisted closure device without serious adverse events.
   Conclusions. In our opinion this modified vacuum-assisted closure therapy is a safe and reproducible option to bridge patients with postoperative deep sternal wound infection to complete healing. Reconstruction of the sternum was achieved in all patients without the use of muscle or omental flap surgery. (C) 2003 by The Society of Thoracic Surgeons.
C1 Univ Lund Hosp, Heart & Lund Div, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital
RP Gustafsson, RI (通讯作者)，Univ Lund Hosp, Heart & Lund Div, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
RI ; Sjögren, Johan/AAZ-6448-2021
OI Ingemansson, Richard/0000-0001-7623-8953; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 21
TC 83
Z9 100
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD DEC
PY 2003
VL 76
IS 6
BP 2048
EP 2053
DI 10.1016/S0003-4975(03)01337-7
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 750JA
UT WOS:000186986500057
PM 14667639
DA 2026-07-24
ER
PT J
AU Eginton, MT
   Brown, KR
   Seabrook, GR
   Towne, JB
   Cambria, RA
AF Eginton, MT
   Brown, KR
   Seabrook, GR
   Towne, JB
   Cambria, RA
TI A prospective randomized evaluation of negative-pressure wound dressings
   for diabetic foot wounds
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 13th Annual Winter Meeting of the Peripheral-Vascular-Surgery-Society
CY JAN 31-FEB 02, 2003
CL SNOWMASS, COLORADO
SP Peripheral Vasc Surg Soc
ID VACUUM-ASSISTED CLOSURE
AB Optimal treatment for large diabetic foot wounds is ill defined. The purpose of this study was to compare the rate of wound healing with the Vacuum Assisted Closure device(TM) (VAC) to conventional moist dressings in the treatment of large diabetic foot wounds. Diabetics with significant soft tissue defects of the foot were considered for enrollment. Patients were randomized to receive either moist gauze dressings or VAC treatments for 2 weeks, after which they were treated with the alternative dressing for an additional 2 weeks. Wounds were photographed weekly and wound dimensions calculated in a blinded fashion with spatial analysis software. Percent change in wound dimensions were calculated and compared for each weekly assessment and over 2 weeks of therapy with each dressing type. Ten patients were enrolled in the trial, but two were lost to follow-up and two were withdrawn. Complete data were available for analysis on seven wounds in six patients. Average length, width, and depth of the wounds at initiation of the trial was 7.7, 3.5, and 3.1 cm, respectively. Only the wound depth was significantly decreased over the weeks of the trial to 1.2 cm (p < 0.05). VAC dressings decreased the wound volume and depth significantly more than moist gauze dressings (59% vs. 0% and 49% vs. 8%, respectively). VAC dressings were associated with a decrease in all wound dimensions while wound length and width increased with moist dressings. In summary, over the first several weeks of therapy, VAC dressings decreased wound depth and volume more effectively than moist gauze dressings. Negative-pressure wound treatment may accelerate closure of large foot wounds in the diabetic patient.
C1 Med Coll Wisconsin, Dept Surg, Div Vasc Surg, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Cambria, RA (通讯作者)，Med Coll Wisconsin, Dept Surg, Div Vasc Surg, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bloomgarden ZT, 2001, DIABETES CARE, V24, P946, DOI 10.2337/diacare.24.5.946
   Evans D, 2001, BRIT J PLAST SURG, V54, P238, DOI 10.1054/bjps.2001.3547
   Joseph E, 2000, WOUNDS, V12, P60
   Langemo D K, 2001, Adv Skin Wound Care, V14, P190, DOI 10.1097/00129334-200107000-00011
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Peters EJG, 2001, DIABETES CARE, V24, P1799, DOI 10.2337/diacare.24.10.1799
   Philippidis TP, 1999, COMPOS STRUCT, V45, P41, DOI 10.1016/S0263-8223(99)00012-4
NR 9
TC 216
Z9 256
U1 0
U2 24
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0890-5096
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD DEC
PY 2003
VL 17
IS 6
BP 645
EP 649
DI 10.1007/s10016-003-0065-3
PG 5
WC Surgery; Peripheral Vascular Disease
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 754CU
UT WOS:000187285800010
PM 14534844
DA 2026-07-24
ER
PT J
AU Conquest, AM
   Garofalo, JH
   Maziarz, DM
   Mendelson, MG
   Sun, YS
   Wooden, WA
   Meadows, WM
   Nifong, W
   Chitwood, WR
AF Conquest, AM
   Garofalo, JH
   Maziarz, DM
   Mendelson, MG
   Sun, YS
   Wooden, WA
   Meadows, WM
   Nifong, W
   Chitwood, WR
TI Hemodynamic effects of the vacuum-assisted closure device on open
   mediastinal wounds
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 36th Annual Meeting of the Association-for-Academic-Surgery
CY NOV 07-09, 2002
CL BOSTON, MASSACHUSETTS
SP Assoc Acad Surg
DE vacuum-assisted closure device; post-sternotomy wound infection; open
   mediastinal wounds
AB Background. Application of the Vacuum-Assisted Closure device (VAC to open sternal wounds has negative hemodynamic effects. We hypothesized that the interposition of a muscle flap attenuates these negative hemodynamic effects.
   Materials and methods. After institutional approval, monitoring lines were placed in anesthetized, ventilated pigs. Through a median sternotomy, sonometric crystals were strategically positioned around the left ventricle. A rectus flap was rotated over the mediastinal wound, and the VAC was placed over the flap. After baseline measurements, a vacuum of 125 mmHg [Group (GP) 1, n = 51 or 50 mmHg (GP2, n = 6) was initiated. Hemodynamics were recorded every 15 min for 1.5 h, and 15 min after cessation of the vacuum therapy. GP3 (n = 6) underwent intermittent VAC cycling (on 5 min/off 2 min). Significance determined by t test.
   Results. While non-flapped animals had significant detriment in both left ventricular filling volume and cardiac output, flapped animals had insignificant depression of both parameters.
   Conclusion. Application of muscle flaps to sternal wounds prior to VAC therapy significantly attenuates the negative hemodynamic effects seen when the VAC is used alone. (C) 2003 Elsevier Inc. All rights reserved.
C1 E Carolina Univ, Brody Sch Med, Dept Surg, Greenville, NC 27858 USA.
   Univ S Florida, Tampa, FL USA.
C3 University of North Carolina; East Carolina University; State University
   System of Florida; University of South Florida
RP Conquest, AM (通讯作者)，E Carolina Univ, Brody Sch Med, Dept Surg, 600 Moye Blvd,TA Room 301, Greenville, NC 27858 USA.
EM conquesta@mail.ecu.edu
CR Arbulu A, 1996, EUR J CARDIO-THORAC, V10, P110, DOI 10.1016/S1010-7940(96)80132-1
   BJERNO T, 1990, Ugeskrift for Laeger, V152, P3699
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Jones G, 1997, ANN SURG, V225, P766, DOI 10.1097/00000658-199706000-00014
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   SARR MG, 1984, ANN THORAC SURG, V38, P415, DOI 10.1016/S0003-4975(10)62300-4
   SONG DH, 2001, PLASTIC RECONSTRUCT, V111, P92
NR 7
TC 29
Z9 43
U1 0
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
J9 J SURG RES
JI J. Surg. Res.
PD DEC
PY 2003
VL 115
IS 2
BP 209
EP 213
DI 10.1016/S0022-4804(03)00331-7
PG 5
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 761JN
UT WOS:000187866900006
PM 14697285
DA 2026-07-24
ER
PT J
AU Colwell, AS
   Donaldson, MC
   Belkin, M
   Orgill, DP
AF Colwell, AS
   Donaldson, MC
   Belkin, M
   Orgill, DP
TI Management of early groin vascular bypass graft infections with
   sartorius and rectus femoris flaps
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ROTATIONAL MUSCLE FLAPS; TERM FOLLOW-UP;
   SALVAGE
AB Groin infections adjacent to vascular bypass grafts continue to be a source of morbidity. The authors reviewed retrospectively 9 consecutive patients with early localized groin infections treated at their institution with sartorius or rectus femoris muscle flaps between 1998 and 2002. All wounds were initially opened and drained. Wounds with necrotic tissue were treated with serial surgical debridements, with a vacuum-assisted closure device, or with wet-to-dry dressing changes. Two bypass grafts were excised and replaced in the presence of marked exposure or pseudoaneurysm. Small wounds were closed with a turnover sartorius flap and larger wounds were closed with either a muscle or musculocutaneous rectus femoris flap. Groin wounds healed in all patients without subsequent graft exposure, rupture, or pseudoaneurysm. Local wound therapy with staged debridement and muscle flaps is effective for most early localized graft infections.
C1 Brigham & Womens Hosp, Div Plast Surg, Dept Surg, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, Dept Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
CR [Anonymous], ANN PLAST SURG
   Atiyeh BS, 1998, ANN PLAS SURG, V41, P640, DOI 10.1097/00000637-199812000-00010
   CHERRY KJ, 1992, J VASC SURG, V15, P295, DOI 10.1016/0741-5214(92)90251-3
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   EVANS GRD, 1993, PLAST RECONSTR SURG, V91, P1294, DOI 10.1097/00006534-199306000-00016
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Graham RG, 2002, PLAST RECONSTR SURG, V109, P108, DOI 10.1097/00006534-200201000-00018
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   KIMMEL RM, 1994, ANN PLAS SURG, V32, P623, DOI 10.1097/00000637-199406000-00011
   MELAND NB, 1994, PLAST RECONSTR SURG, V93, P1005, DOI 10.1097/00006534-199404001-00015
   MIXTER RC, 1989, J VASC SURG, V9, P472, DOI 10.1067/mva.1989.vs0090472
   Moran SL, 2002, PLAST RECONSTR SURG, V109, P999, DOI 10.1097/00006534-200203000-00031
   Morykwas M. J., 1997, ANN PLAST SURG, V38, P563
   PerezBurkhardt JL, 1995, J CARDIOVASC SURG, V36, P581
   PERLER BA, 1993, J VASC SURG, V18, P358, DOI 10.1016/0741-5214(93)90252-H
   Taylor SM, 1996, ANN VASC SURG, V10, P117, DOI 10.1007/BF02000754
   Zeltsman D, 1999, AM SURGEON, V65, P331
NR 17
TC 53
Z9 61
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JAN
PY 2004
VL 52
IS 1
BP 49
EP 53
DI 10.1097/01.sap.0000099960.68038.53
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 762BD
UT WOS:000187949300009
PM 14676699
DA 2026-07-24
ER
PT J
AU Demaria, RG
   Giovannini, UM
   Téot, L
   Frapier, JM
   Albat, B
AF Demaria, RG
   Giovannini, UM
   Téot, L
   Frapier, JM
   Albat, B
TI Topical negative pressure therapy. A very useful new method to treat
   severe infected vascular approaches in the groin
SO JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE wound infection; wound healing; vascular surgical procedures; groin;
   femoral artery
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; COMPLICATIONS; MANAGEMENT;
   GRAFTS
AB Aim. The treatment of infected vascular surgery sites is challenging. Negative pressure applied uniformly to the entire wound surface has been shown to allow granulation tissue formation and to promote healing of acute and chronic wounds.
   Methods. We used the Vacuum-Assisted Closure (VAC, Kinetic Concepts Incorporated, San Antonio, Texas, USA) system in 4 patients with severe groin wound infection after emergency surgery on the femoral artery.
   Results. In all 4 patients, general health improved and the wound changed rapidly from a large infected cavity to a minor lesion readily covered using a simple surgical technique.
   Conclusion. This study establishes VAC as a very valuable tool for managing severe complications of groin vascular surgery sites even in patients with obesity and/or diabetes mellitus.
C1 Montpellier Teaching Hosp, Arnaud de Villeneuve Hosp, Dept Cardiovasc Surg, F-34295 Montpellier, France.
   Montpellier Teaching Hosp, Dept Plast Surg, F-34295 Montpellier, France.
   Montpellier Teaching Hosp, Lapeyronie Hosp, Burn Unit, F-34295 Montpellier, France.
C3 Universite de Montpellier; CHU de Montpellier; Universite de
   Montpellier; CHU de Montpellier; Universite de Montpellier; CHU de
   Montpellier
RP Demaria, RG (通讯作者)，Montpellier Teaching Hosp, Arnaud de Villeneuve Hosp, Dept Cardiovasc Surg, 371 Av Doyen G Giraud, F-34295 Montpellier, France.
EM roland.demaria@wanadoo.fr
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baynham S A, 1999, Ostomy Wound Manage, V45, P28
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   Giovannini UM, 2001, ANN PLAS SURG, V47, P577, DOI 10.1097/00000637-200111000-00022
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
   Greer SE, 1999, ANN PLAS SURG, V43, P551, DOI 10.1097/00000637-199911000-00016
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   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 22
TC 31
Z9 38
U1 0
U2 1
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0021-9509
EI 1827-191X
J9 J CARDIOVASC SURG
JI J. Cardiovasc. Surg.
PD DEC
PY 2003
VL 44
IS 6
BP 757
EP 761
PG 5
WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 773UF
UT WOS:000188941600015
PM 14735041
DA 2026-07-24
ER
PT J
AU Simman, R
   Forte, R
   Silverberg, B
   Moriera-Gonzalez, A
   Williams, F
AF Simman, R
   Forte, R
   Silverberg, B
   Moriera-Gonzalez, A
   Williams, F
TI A comparative histological study of skin graft take with tie-over
   bolster dressing versus negative pressure wound therapy in a pig model:
   A preliminary study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Negative pressure wound therapy (NPWT) (Vacuum-Assisted Closure((R)), V.A.C.((R)), Kinetic Concepts Inc., San Antonio, Texas) has been shown to accelerate wound healing in animal and clinical studies. This is due to removal of interstitial fluids, which increases oxygen and nutrient delivery to tissues, increased vascularity and granulation tissue, decreased bacterial colonization, and removal of inhibitory factors from chronic wound edema. A histological study was recommended in the original article to give scientific answers regarding the positive effect of NPWT on the healing process of the skin graft. In this study, two meshed split-thickness skin grafts were performed in a mirror image on the back of a pig. On one side a conventional bolster, dressing was applied, and on the other side the NPWT system was used. Three days later, both dressings were removed and core biopsies were obtained from each side on postoperative Days 3, 5, 7, 9, and 11. The NPWT side showed less wound edema, faster narrowing of the separation plane between the graft and the recipient wound bed, and earlier termination of the acute inflammatory reaction.
C1 Wright State Univ, Miami Valley Hosp, Dept Surg, Div Plast Surg, Dayton, OH 45409 USA.
   Providence Hosp, Med Ctr, Dept Pathol, Southfield, MI 48037 USA.
   Providence Hosp, Dept Surg, Div Plast Surg, Southfield, MI 48037 USA.
C3 University System of Ohio; Wright State University Dayton; Miami Valley
   Hospital
RP Simman, R (通讯作者)，Wright State Univ, Miami Valley Hosp, Dept Surg, Div Plast Surg, Weber Bldg Hlth Educ,7th Floor,1 Wyoming St, Dayton, OH 45409 USA.
EM RichardSimman@hotmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   de Lange MY, 2000, EUR J PLAST SURG, V23, P178, DOI 10.1007/s002380050244
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Wu SH, 2000, EUR J PLAST SURG, V23, P174, DOI 10.1007/s002380050243
NR 5
TC 21
Z9 28
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2004
VL 16
IS 2
BP 76
EP 80
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 774UQ
UT WOS:000189004100006
DA 2026-07-24
ER
PT J
AU Mouës, CM
   Vos, MC
   Van den Bemd, GJCM
   Stijnen, T
   Hovius, SER
AF Mouës, CM
   Vos, MC
   Van den Bemd, GJCM
   Stijnen, T
   Hovius, SER
TI Bacterial load in relation to vacuum-assisted closure wound therapy: A
   prospective randomized trial
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID TEMPORARY ABDOMINAL CLOSURE; MATRIX-METALLOPROTEINASES; SUBATMOSPHERIC
   PRESSURE; STAPHYLOCOCCUS-AUREUS; 7-YEAR EXPERIENCE; NEGATIVE-PRESSURE;
   PACK TECHNIQUE; VENOUS ULCERS; LEG ULCERS; INFECTION
AB Vacuum-assisted closure has become a new technique in the challenging management of contaminated, acute, and chronic wounds. Although promising clinical results have been described, scientific proof to substantiate the mechanism of action of this therapy is scarce. In the present study, we examined whether the positive effect on wound healing found in vacuum-assisted closure-treated wounds could be explained by an effect on the bacterial load. Fifty-four patients who needed open wound management before surgical closure were included in this study. Wounds were randomized to either vacuum-assisted closure therapy (n= 29) or treatment by conventional moist gauze therapy (n= 25). Healing was characterized by development of a clean granulating wound bed ("ready for surgical therapy") and reduction of wound surface area. To quantify bacterial load, biopsies were collected. No significant difference was found in time needed to reach "ready for surgical therapy" comparing both therapies. Wound surface area reduction was significantly larger in vacuum-assisted closure-treated wounds: 3.8 +/- 0.5 percent/day (mean +/- SEM) compared to conventional-treated wounds (1.7 +/- 0.6 percent/day; p < 0.05). The total quantitative bacterial load was generally stable in both therapies. However, nonfermentative gram negative bacilli showed a significant decrease in vacuum-assisted closure-treated wounds (p < 0.05), whereas Staphylococcus aureus showed a significant increase in vacuum-assisted closure-treated wounds (p < 0.05). In conclusion, this study shows a positive effect of vacuum-assisted closure therapy on wound healing, expressed as a significant reduction of wound surface area. However, this could not be explained by a significant quantitative reduction of the bacterial load.
C1 Erasmus MC, Dept Plast & Reconstruct Surg, NL-3000 DR Rotterdam, Netherlands.
   Erasmus MC, Dept Med Microbiol & Infect Dis, NL-3000 DR Rotterdam, Netherlands.
   Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC
RP Mouës, CM (通讯作者)，Erasmus MC, Dept Plast & Reconstruct Surg, POB 1738, NL-3000 DR Rotterdam, Netherlands.
EM c.moues@erasmusmc.nl
RI vos, margreet/AFF-9452-2022
OI vos, margreet/0000-0002-0496-7038
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   Stenmark KR, 2000, PHYSIOL RES, V49, P503, DOI 10.33549/physiolres.930000.49.503
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
   THOMSON PD, 1994, AM J SURG, V167, pS7, DOI 10.1016/0002-9610(94)90003-5
   Thoner B, 1998, Krankenpfl J, V36, P78
   Trengove NJ, 2000, WOUND REPAIR REGEN, V8, P13, DOI 10.1046/j.1524-475x.2000.00013.x
   URSCHEL JD, 1988, BRIT J PLAST SURG, V41, P182, DOI 10.1016/0007-1226(88)90049-5
   Webb LX, 2001, UNFALLCHIRURG, V104, P918, DOI 10.1007/PL00002776
   Wright JB, 2002, WOUND REPAIR REGEN, V10, P141, DOI 10.1046/j.1524-475X.2002.10308.x
   Wu SH, 2000, EUR J PLAST SURG, V23, P174, DOI 10.1007/s002380050243
NR 51
TC 402
Z9 481
U1 0
U2 42
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN
PY 2004
VL 12
IS 1
BP 11
EP 17
DI 10.1111/j.1067-1927.2004.12105.x
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 776WX
UT WOS:000189143300003
PM 14974959
DA 2026-07-24
ER
PT J
AU Schimp, VL
   Worley, C
   Brunello, S
   Levenback, CC
   Wolf, JK
   Sun, CC
   Bodurka, DC
   Ramirez, PT
AF Schimp, VL
   Worley, C
   Brunello, S
   Levenback, CC
   Wolf, JK
   Sun, CC
   Bodurka, DC
   Ramirez, PT
TI Vacuum-assisted closure in the treatment of gynecologic oncology wound
   failures
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
DE vacuum-assisted closure; wound failure
AB Objective. Negative pressure wound vacuum therapy can expedite the healing of complex wound failures. Our aim was to evaluate the use of a vacuum-assisted closure (VAC) device to treat complex wound failures in gynecologic oncology patients.
   Methods. We retrospectively identified 27 patients with gynecologic malignancies in whom the device was used to treat complex wound failures from January 2001 to May 2002 at our institution. We analyzed operative data and information regarding the diagnosis and management of these complex wound failures and the length of time the device was used.
   Results. The procedures performed before wound VAC placement were total abdominal hysterectomy with bilateral salpingooopherectomy with or without tumor reductive surgery in 14 patients, vulvectomy with or without inguinal lymph node dissection in five patients, skin or myocutaneous grafting in three patients, parastomal hemiorrhaphy in two patients, retroperitoneal lymph node dissection in two patients, and incision and drainage of a gluteal abscess after radiation therapy in one patient. Four of the 27 patients had the VAC device placed at the time of a reoperation, while the remaining 23 patients had the VAC device placed postoperatively for wound failures. Wound breakdown occurred at a median of 9 days (range: 0-88 days) postoperatively. Overall, there was a 96% reduction (range: 0-100%) in the median size of wound defects from 330 to 14.0 cm(3) with use of the VAC device. The median number of days of VAC therapy was 32 days (range: 3-88 days). Twenty patients used this device as outpatients, and the charge per day was approximately US$150.00. One patient experienced bleeding, and 26 patients experienced no complications. The only complaint was pain during dressing changes (67% of patients). The mean follow-up was 52 days (range: 0-270 days). At the time of last contact, 26 (96%) of 27 patients had complete wound healing.
   Conclusions. VAC therapy is a novel treatment using controlled negative pressure to evacuate wound fluid, stimulate granulation tissue, and to decrease bacterial colonization of the wound. Our experience indicates that this is a safe method to treat complex wound failures in gynecologic oncology patients. (C) 2003 Published by Elsevier Inc.
C1 Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Nursing & Wound, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Ost, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Continence Nursing, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center; University of Texas System;
   UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson
   Cancer Center
RP Ramirez, PT (通讯作者)，Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, 1515 Holcombe Blvd,Unit 440, Houston, TX 77030 USA.
EM peramire@mdanderson.org
OI Bodurka, Diane/0000-0001-6703-7607
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta PA, 2002, OBSTET GYNECOL, V99, P497, DOI 10.1016/S0029-7844(01)01752-5
   *KIN CONC, 2002, VAC ASS CLOS REC GUI
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   MORROW PC, 1996, GYNECOLOGIC CANC SUR, P141
   Morykwas M, 1993, 25 ANN C WOUND OST C
   MORYKWAS MJ, 1997, ANN PLAST SURG, V38, P554
   RYAN T, 1983, PHYS FACTORS ANGIOGE, P182
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
NR 10
TC 51
Z9 62
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
EI 1095-6859
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD FEB
PY 2004
VL 92
IS 2
BP 586
EP 591
DI 10.1016/j.ygyno.2003.10.055
PG 6
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA 779DX
UT WOS:000189281100012
PM 14766251
DA 2026-07-24
ER
PT J
AU Bihariesingh, VJ
   Stolarczyk, EM
   Karim, RB
   van Kooten, EO
AF Bihariesingh, VJ
   Stolarczyk, EM
   Karim, RB
   van Kooten, EO
TI Plastic solutions for orthopaedic problems
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE postoperative wounds; plastic surgery; flaps; osteosynthesis;
   arthroplasty
ID VACUUM-ASSISTED CLOSURE; PROSTHESIS; COVERAGE
AB Introduction: Infection and exposure of the implant may occur in 1-12% of patients operated on for arthroplasty or osteosynthesis. Variables such as tissue viability, presence of infection, exposure of osteosynthesis material and patient-related factors contribute to the lack of general consensus regarding the management of these defects. Materials and methods: Between January 1999 and January 2001, six patients were treated for complex soft-tissue defects following various orthopaedic procedures at the Department of Plastic Surgery in the Slotervaartziekenhuis in Amsterdam, a rheuma-orthopaedic orientated hospital. All patients were initially treated by radical debridement and vacuum-assisted closure ( VAC) system of the wound. After 1 week, this was followed by transplantation of a pedicled or free flap to cover the defect. We studied the medical history, initial orthopaedic procedure, wound treatment, transplanted flap and outcome of plastic surgery in this group. Results: Plastic surgical intervention led to wound closure in all cases. In only one case was the osteosynthesis material removed because of osteomyelitis. Conclusions: We conclude that the earlier coverage with vital tissue is obtained, the lower the incidence of infection. Early consultation by a plastic surgeon will increase a positive outcome of treatment of complex tissue defects.
C1 Onze Lieve Vrouw Hosp, Dept Plast & Reconstruct Surg, NL-1090 HM Amsterdam, Netherlands.
   Acad Ziekenhuis, Dept Orthopaed Surg, Paramaribo, Suriname.
C3 Onze Lieve Vrouwe Gasthuis Hospital
RP Karim, RB (通讯作者)，Onze Lieve Vrouw Hosp, Dept Plast & Reconstruct Surg, POB 95500, NL-1090 HM Amsterdam, Netherlands.
EM rbkarim@xs4all.nl
OI Karim, Refaat B/0000-0001-8162-2140
CR ADAM RF, 1994, J BONE JOINT SURG BR, V76B, P750, DOI 10.1302/0301-620X.76B5.8083264
   CHANDRASEKHAR B, 1993, ORTHOP CLIN N AM, V24, P523
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   GERWIN M, 1993, CLIN ORTHOP RELAT R, V286, P64
   GREENBERG B, 1989, PLAST RECONSTR SURG, V83, P85, DOI 10.1097/00006534-198901000-00016
   HALLOCK GG, 1995, PLAST SURG TECH, V1, P47
   JOHNSON DP, 1993, ACTA ORTHOP SCAND S, V252, P5
   Kramhoft M, 1994, J Arthroplasty, V9, P617, DOI 10.1016/0883-5403(94)90115-5
   LAING JHE, 1992, BRIT J PLAST SURG, V45, P66
   LESAVOY MA, 1989, PLAST RECONSTR SURG, V83, P90, DOI 10.1097/00006534-198901000-00017
   LIAN G, 1989, J ARTHROPLASTY S, V4, P23
   MARKOVICH GD, 1995, CLIN ORTHOP RELAT R, V321, P122
   Mont MA, 1997, J ARTHROPLASTY, V12, P426, DOI 10.1016/S0883-5403(97)90199-6
   Nahabedian MY, 1999, PLAST RECONSTR SURG, V104, P1688, DOI 10.1097/00006534-199911000-00012
   Sposato G, 2001, BRIT J PLAST SURG, V54, P235, DOI 10.1054/bjps.2000.3537
   TAYLOR S, 1994, CAN J SURG, V37, P217
NR 16
TC 18
Z9 27
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD MAR
PY 2004
VL 124
IS 2
BP 73
EP 76
DI 10.1007/s00402-003-0615-8
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 780GT
UT WOS:000189364500001
PM 14730453
DA 2026-07-24
ER
PT J
AU Stoeckel, WT
   David, L
   Levine, EA
   Argenta, AE
   Perrier, ND
AF Stoeckel, William T.
   David, Lisa
   Levine, Edward A.
   Argenta, Anne E.
   Perrier, Nancy D.
TI Vacuum-assisted closure for the treatment of complex breast wounds
SO BREAST
LA English
DT Article
DE breast; surgery; wound; vacuum
AB Complex breast wounds are a constant problem for surgeons. Wound vacuum-assisted closure therapy (VAC) has been shown to be effective for a variety of complex wounds. Our goal was to evaluate our experience with the (VAC) device in the treatment of open breast wounds.
   We retrospectively identified 18 patients with complex breast wounds treated with the VAC. We analyzed the data regarding the nature and management of these wounds using the VAC device.
   Fifteen of 18 patients were treated effectively using the VAC. Two patients required muscle flap coverage. One patient had the VAC dressing discontinued secondary to a denial by an insurance company for VAC in the home setting.
   VAC therapy is an effective treatment for complex wounds. Specifically, our experience shows it to be effective in the treatment of complex breast wounds. Utilization of VAC therapy should be considered for the management of these challenging wounds. (C) 2005 Published by Elsevier Ltd.
C1 [Stoeckel, William T.; David, Lisa; Levine, Edward A.; Argenta, Anne E.; Perrier, Nancy D.] Wake Forest Univ, Bowman Gray Sch Med, Surg Oncol Serv, Baptist Med Ctr, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP David, L (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Surg Oncol Serv, Baptist Med Ctr, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM ldavid@wfubmc.edu
RI Perrier, Nancy/T-7474-2019
CR Baynham S A, 1999, Ostomy Wound Manage, V45, P28
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Bland K I:., 1998, The Breast: comprehension management of benign and malignant diseases, P75
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Joseph E, 2000, WOUNDS, V12, P60
   LACEY J, 2002, ENV MAL MUTAGEN, V8, P82
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Stonerock CE, 2003, AM SURGEON, V69, P1030
NR 11
TC 19
Z9 20
U1 0
U2 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0960-9776
J9 BREAST
JI Breast
PD OCT
PY 2006
VL 15
IS 5
BP 610
EP 613
DI 10.1016/j.breast.2005.11.006
PG 4
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA V44PR
UT WOS:000203015100008
PM 16443363
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Malmsjö, M
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Ingemansson, Richard
TI No hypoperfusion is produced in the epicardium during application of
   myocardial topical negative pressure in a porcine model
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ENDOTHELIAL GROWTH-FACTOR; STERNAL
   WOUND-INFECTION; LONG-TERM SURVIVAL; ANGIOGENIC GENE-THERAPY;
   RISK-FACTORS; MEDIASTINITIS; EXPRESSION; COMPLICATIONS; IMPACT
AB Background: Topical negative pressure (TNP), commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in skeletal muscle. We have previously shown that a myocardial TNP of -50 mmHg significantly increases microvascular blood flow in the myocardium. When TPN is used in wound therapy (on skeletal and subcutaneous tissue) a zone of relative hypoperfusion is seen close to the wound edge. Hypoperfusion induced by TNP is thought to depend on tissue density, distance from the negative pressure source, and the amount negative pressure applied. When applying TNP to the myocardium, a significant, long-standing zone of hypoperfusion could theoretically cause ischemia, and negative effects on the myocardium. The current study was designed to elucidate whether hypoperfusion was produced during myocardial TNP.
   Methods: Six pigs underwent median sternotomy. Laser Doppler probes were inserted horizontally into the heart muscle in the LAD area, at depths of approximately, 1-2 mm. The microvascular blood flow was measured before and after the application of a TNP. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 minutes of LAD occlusion (ischemic myocardium).
   Results: A TNP of -50 mmHg induced a significant increase in microvascular blood flow in normal myocardium (**p = 0.01), while -125 mmHg did not significantly alter the microvascular blood flow. In ischemic myocardium a TNP of -50 mmHg induced a significant increase in microvascular blood flow (*p = 0.04), while -125 mmHg did not significantly alter the microvascular blood flow.
   Conclusion: No hypoperfusion could be observed in the epicardium in neither normal nor ischemic myocardium during myocardial TNP.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Malmsjo, Malin] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se; malin.malmsjo@skane.se;
   richard.ingemansson@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953; Lindstedt, Sandra/0000-0003-4484-6473
FU Anders Otto Sward's Foundation/Ulrika Eklund's Foundation; Anna Lisa and
   Sven Eric Lundgren's Foundation; Ake Wiberg Foundation; M. Bergvall
   Foundation; Swedish Medical Association; Royal Physiographic Society in
   Lund; Swedish Medical Research Council; Crafoord Foundation; Swedish
   Heart-Lung Foundation; Swedish Government; Swedish Hypertension Society
FX We would like to thank Johan Ingemansson (Statistical Solutions IP) for
   his expert contribution to the statistic analyses. This study was
   supported by Anders Otto Sward's Foundation/Ulrika Eklund's Foundation,
   Anna Lisa and Sven Eric Lundgren's Foundation for medical research, the
   Ake Wiberg Foundation, the M. Bergvall Foundation, the Swedish Medical
   Association, the Royal Physiographic Society in Lund, the Swedish
   Medical Research Council, the Crafoord Foundation, the Swedish
   Heart-Lung Foundation, the Swedish Government Grant for Clinical
   Research, and the Swedish Hypertension Society.
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NR 34
TC 8
Z9 10
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PY 2007
VL 2
AR 53
DI 10.1186/1749-8090-2-53
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA V83HU
UT WOS:000205631000053
PM 18062803
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Niezgoda, JA
   Cabigas, EB
   Allen, HK
   Simanonok, JP
   Kindwall, EP
   Krumenauer, J
AF Niezgoda, Jeffrey A.
   Cabigas, E. Bernadette
   Allen, Heidi K.
   Simanonok, John P.
   Kindwall, Eric P.
   Krumenauer, James
TI Managing Pyoderma Gangrenosum: A Synergistic Approach Combining Surgical
   Debridement, Vacuum-Assisted Closure, and Hyperbaric Oxygen Therapy
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID DIAGNOSIS
C1 [Niezgoda, Jeffrey A.; Cabigas, E. Bernadette; Allen, Heidi K.; Simanonok, John P.; Kindwall, Eric P.; Krumenauer, James] Hyperbar & Wound Care Associates, Ctr Comprehens Wound Care & Hyperbar Oxygen Thera, Aurora Hlth Care, St Lukes Med Ctr, Milwaukee, WI 53215 USA.
RP Niezgoda, JA (通讯作者)，Hyperbar & Wound Care Associates, Ctr Comprehens Wound Care & Hyperbar Oxygen Thera, Aurora Hlth Care, St Lukes Med Ctr, 2901 W Kinnickinnic River Pkwy,Suite 311, Milwaukee, WI 53215 USA.
EM niezgoda@execpc.com
RI Niezgoda, Jeffrey/KZU-8352-2024
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   Wolf R, 1998, ARCH DERMATOL, V134, P1071, DOI 10.1001/archderm.134.9.1071
NR 25
TC 46
Z9 51
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD FEB
PY 2006
VL 117
IS 2
BP 24E
EP 28E
DI 10.1097/01.prs.0000200776.13868.02
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA V13OF
UT WOS:000207675400002
PM 16462310
DA 2026-07-24
ER
PT J
AU Kang, GCW
   Yam, A
AF Kang, Gavin C. W.
   Yam, Andrew
TI Vacuum-assisted closure of a large palmar defect after debriding a
   midpalmar tuberculous abscess
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Hand; Surgery; Tuberculous infection; Vacuum-assisted closure
AB A rare case of tuberculous deep palmar abscess of the hand was treated with radical excisional debridement, resulting in a large palmar skin and soft tissue defect that was successfully closed with a vacuum dressing followed by split skin grafting. Vacuum dressings are useful adjuncts to treat large soft tissue defects in patients who are unsuitable for complex reconstruction. The moist wound environment prevents desiccation of exposed vital structures and decreases pain, allowing early mobilisation in the hand. The wound granulates and contracts rapidly, allowing earlier skin grafting or faster healing by secondary intention. The closed system vacuum dressing is particularly useful in managing debrided tuberculous soft tissue infections. The dressing is perfectly sealed and requires less frequent changing, decreasing contamination and transmission of tuberculosis to other patients and health care staff, while minimising the risk of secondary nosocomial bacterial infection of the wound.
C1 [Kang, Gavin C. W.; Yam, Andrew] Singapore Gen Hosp, Dept Hand Surg, Singapore 169608, Singapore.
C3 Singapore General Hospital
RP Kang, GCW (通讯作者)，Singapore Gen Hosp, Dept Hand Surg, Outram Rd, Singapore 169608, Singapore.
EM gavinkangcw@yahoo.com
RI Yam, Andrew/LJL-4259-2024
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Ford SJ, 2005, EUR J CARDIO-THORAC, V28, P645, DOI 10.1016/j.ejcts.2005.05.030
   Visuthikosol V, 1996, ANN PLAS SURG, V37, P55, DOI 10.1097/00000637-199607000-00009
   Wongworawat MD, 2003, CLIN ORTHOP RELAT R, P45, DOI 10.1097/01.blo.0000084400.53464.02
NR 6
TC 8
Z9 8
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD MAR
PY 2008
VL 5
IS 1
BP 45
EP 48
DI 10.1111/j.1742-481X.2007.00369.x
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AT
UT WOS:000207843200008
PM 18336379
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Uygur, F
   Duman, H
   Ülkür, E
   Çeiköz, B
AF Uygur, Fatih
   Duman, Haluk
   Ulkur, Ersin
   Ceikoz, Bahattin
TI The role of the vacuum-assisted closure therapy in the salvage of venous
   congestion of the free flap: case report
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Free flap; VAC therapy; Venous congestion
ID ISCHEMIA
AB Indications for vacuum-assisted closure (VAC) therapy described generally include acute, chronic, traumatic wounds and ulcers. Recent studies related to investigating new applications of VAC therapy have begun to be reported at literature in many aspects. We used this technique in a novel area. A 21-year-old man presented who suffered venous congestion in anterolateral thigh fasciocutaneous flap at the postoperative second day. Following two cycles of VAC therapy, 72 hours later, venous congestion disappeared. Application of VAC therapy to the flap helps removal of excess interstitial fluid because of increased pressure gradients. It seems that VAC therapy is an option in venous congestion when the interstitial pressure rises above capillary pressure.
C1 [Uygur, Fatih; Duman, Haluk; Ulkur, Ersin; Ceikoz, Bahattin] Haydarpasa Training Hosp, Dept Plast & Reconstruct Surg, Istanbul, Turkey.
   [Uygur, Fatih; Duman, Haluk; Ulkur, Ersin; Ceikoz, Bahattin] Haydarpasa Training Hosp, Burn Unit, Gulhane Mil Med Acad, Istanbul, Turkey.
   [Uygur, Fatih; Duman, Haluk; Ulkur, Ersin; Ceikoz, Bahattin] Haydarpasa Training Hosp, Fac Med, Istanbul, Turkey.
C3 Istanbul Haydarpasa Numune Training & Research Hospital; Istanbul
   Haydarpasa Sultan Abdulhamid Training & Research Hospital; Gulhane
   Training & Research Hospital; Istanbul Haydarpasa Numune Training &
   Research Hospital; Istanbul Haydarpasa Sultan Abdulhamid Training &
   Research Hospital; Istanbul Haydarpasa Numune Training & Research
   Hospital; Istanbul Haydarpasa Sultan Abdulhamid Training & Research
   Hospital
RP Uygur, F (通讯作者)，Haydarpasa Training Hosp, Dept Plast & Reconstruct Surg, Istanbul, Turkey.
EM fatihuygur@hotmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   de Lange MY, 2000, EUR J PLAST SURG, V23, P178, DOI 10.1007/s002380050244
   HJORTDAL VE, 1994, PLAST RECONSTR SURG, V93, P366, DOI 10.1097/00006534-199402000-00023
   Joseph E, 2000, WOUNDS, V12, P60
   KERRIGAN CL, 1994, PLAST RECONSTR SURG, V93, P1485
   LINEAWEAVER WC, 1991, BLOOD COAGUL FIBRIN, V2, P189, DOI 10.1097/00001721-199102000-00029
   MARKS MW, 1997, 66 ANN M AM SOC PLAS
   Orgill DP, 2004, WOUNDS, P1
   SCHNEIDER AM, 1996, 41 ANN M PLAST SURG
   Schuster R, 2006, AM SURGEON, V72, P129
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   Yang Charlie C, 2006, J Surg Orthop Adv, V15, P19
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NR 15
TC 30
Z9 33
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR
PY 2008
VL 5
IS 1
BP 50
EP 53
DI 10.1111/j.1742-481X.2007.00362.x
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AT
UT WOS:000207843200009
PM 18179554
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Sjögren, J
   Mokhtari, A
   Gustafsson, R
   Malmsjö, M
   Nilsson, J
   Ingemansson, R
AF Sjogren, Johan
   Mokhtari, Arash
   Gustafsson, Ronny
   Malmsjo, Malin
   Nilsson, Johan
   Ingemansson, Richard
TI Vacuum-assisted closure therapy for deep sternal wound infections: the
   impact of learning curve on survival and predictors for late mortality
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Mediastinitis; Postoperative complications; Surgical wound infection
AB The aim of this study was to evaluate the possible learning curve effects on survival during the introduction of vacuum-assisted closure (VAC) therapy in patients with deep sternal wound infection (DSWI). Furthermore, predictors of late mortality were analysed and causes of late death were examined. Fifty-three patients (early Group, n = 26, January 1999 to July 2001 versus late group, n = 27, August 2001 to March 2003) were all treated with VAC for DSWI. A follow-up was carried out in September 2006. Multivariate analyses were used to evaluate the predictors of late mortality. The 90-day mortality was 0% in both groups. The survival rates at 5 years were 69.2 +/- 9.1% (early group) versus 58.5 +/- 11.7% (late group), P = ns (non significant). The time interval from cardiac surgery to diagnosis of DSWI and prolonged VAC therapy were identified as independent predictors of late mortality. Our concept for VAC therapy in DSWI seems to be readily introduced in clinical practice. There was no difference in survival between our initial cases and later cases. Late diagnosis and prolonged wound therapy were identified as predictors for late mortality.
C1 [Sjogren, Johan] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, SE-22185 Lund, Sweden.
   [Malmsjo, Malin] Univ Lund Hosp, Dept Internal Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Sjögren, J (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, SE-22185 Lund, Sweden.
EM johan.sjogren@med.lu.se
RI ; Nilsson, Johan/A-4742-2011; Sjögren, Johan/AAZ-6448-2021
OI Maljö, Malin/0000-0001-9849-9599; Nilsson, Johan/0000-0001-6860-6090;
   Ingemansson, Richard/0000-0001-7623-8953; 
FU Region Skane Research Funds; Lund University Hospital
FX This study was made possible by grants from the Region Skane Research
   Funds and the Donation Funds of Lund University Hospital. Financial
   disclosure: JS, RG, MM and RI have received lecture honorarium from KCI
   Europe.
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
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   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
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NR 24
TC 18
Z9 19
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2008
VL 5
IS 2
BP 216
EP 223
DI 10.1111/j.1742-481X.2007.00371.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AW
UT WOS:000207843500010
PM 18494627
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Trueman, P
   Flack, S
   Loonstra, A
   Hauser, T
AF Trueman, Paul
   Flack, Sarah
   Loonstra, Ate
   Hauser, Tino
TI The feasibility of using VAC® Therapy in home care patients with
   surgical and traumatic wounds in the Netherlands
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Home care; Surgical; Trauma; VAC; Wounds
AB The aim of this study was to review the feasibility of using vacuum-assisted closure (V.A.C.(R)) Therapy for the management of surgical and traumatic wounds in the home care settings in the Netherlands. De-identified patient data were collected from a health insurance database in the Netherlands. All patients with complete records, including indication, age, duration of therapy and defined treatment goal between January and November 2006 were included. Data from 338 patients were analysed. On average, wounds had been present for 2 months before start of V. A. C. Therapy. Overall, 74% of patients reached the pre-defined therapy goal (77% for dehisced wounds, 68% for abdominal wounds, 73% for traumatic wounds and 91% for sternal wounds) with approximately 1 month of V. A. C. Therapy. There was a negative association between the wound duration prior to V.A.C. Therapy and the treatment success rate (r = -0.162, P = 0.003). Wounds with shorter duration (< 4 weeks) prior to initiation of V. A. C. Therapy achieved an 82% success rate compared with 33% for wounds present for > 6 months prior to V. A. C. Therapy. V. A. C. Therapy is a feasible and effective treatment for surgical and traumatic wounds in home care patients with over 70% of patients treated in this sample achieving pre-defined treatment goals. The success rate of V. A. C. Therapy is negatively associated with the duration of the wound before V. A. C. Therapy is commenced.
C1 [Trueman, Paul; Flack, Sarah] Univ York, York Hlth Econ Consortium, York YO10 5NH, N Yorkshire, England.
   [Loonstra, Ate; Hauser, Tino] KCI Europe Holding BV, Amstelveen, Netherlands.
C3 University of York - UK
RP Trueman, P (通讯作者)，Univ York, York Hlth Econ Consortium, Market Sq,Vanbrugh Way, York YO10 5NH, N Yorkshire, England.
EM pt507@york.ac.uk
FU KCI Medical
FX This research was supported by funding from KCI Medical. PT has received
   institutional funding from KCI Medical to support previous research. The
   remaining authors have no potential conflicts to declare.
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NR 29
TC 4
Z9 6
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2008
VL 5
IS 2
BP 225
EP 231
DI 10.1111/j.1742-481X.2008.00472.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AW
UT WOS:000207843500011
PM 18494628
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Noble-Bell, G
   Forbes, A
AF Noble-Bell, Georgia
   Forbes, Angus
TI A systematic review of the effectiveness of negative pressure wound
   therapy in the management of diabetes foot ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Diabetes mellitus; Foot ulcer; Negative pressure wound therapy;
   Systematic review; Vacuum-assisted closure
AB Foot ulcers are a common complication in patients with diabetes. Negative pressure wound therapy (NPWT) is a wound care therapy that is being increasingly used in the management of foot ulcers. This article presents a systematic review examining the effectiveness of this therapy. The review question is how effective is NPWT in achieving wound healing in diabetes foot ulcers? The primary outcome for this study was the number of patients achieving complete wound healing (secondary outcomes, other markers of wound healing, adverse events and patient satisfaction). A systematic literature review and tabulative synthesis of randomised controlled trials (RCTs). The review identified four RCTs of weak to moderate quality. Only one study examining NPWT in postamputation wound healing reported data on the primary outcome. These data show a 20% improvement in wound healing [odds ratios = 2.0%, confidence interval (CI) -1.0 to 4.0] and number needed to treat 6 (CI 4-64). No serious treatment-related complications were reported by any of the studies. One study suggested a reduction in the risk of secondary amputation (absolute risk reduction = 7.9%, CI 0.5-15.43). Studies also reported an increase in granulation and wound-healing rates in patients treated with NPWT therapy. No data on patient satisfaction or experience were reported. While all the studies included in the review indicated that the NPWT therapy is more effective than conventional dressings, the quality of the studies were weak and the nature of the inquiries in terms of outcome and patient selection divergent. There is a strong need for larger trials to assess NPWT therapy in diabetes care with different groups of patients and in relation to different clinical objectives and parameters.
C1 [Noble-Bell, Georgia; Forbes, Angus] Kings Coll London, Florence Nightingale Sch Nursing & Midwifery, London SE1 8WA, England.
C3 University of London; King's College London
RP Forbes, A (通讯作者)，Kings Coll London, Florence Nightingale Sch Nursing & Midwifery, James Clerk Maxwell Bldg,57 Waterloo Rd, London SE1 8WA, England.
EM angus.forbes@kcl.ac.uk
OI Forbes, Angus/0000-0003-3331-755X
FU Mel Doxford (Diabetes Foot Practitioner)
FX The authors would like to acknowledge the support of Mel Doxford
   (Diabetes Foot Practitioner) and Dr Mike Edmonds (Consultant
   Diabetologist) who provided clinical expertise in conducting and writing
   the review.
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NR 31
TC 39
Z9 46
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2008
VL 5
IS 2
BP 233
EP 242
DI 10.1111/j.1742-481X.2008.00430.x
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AW
UT WOS:000207843500012
PM 18494629
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Campbell, PE
   Smith, GS
   Smith, JM
AF Campbell, Penny E.
   Smith, Gary S.
   Smith, Jennifer M.
TI Retrospective clinical evaluation of gauze-based negative pressure wound
   therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Gauze; Negative pressure wound therapy; Chariker-Jeter
AB Negative pressure wound therapy (NPWT) is an established modality in the treatment of challenging wounds. However, most existing clinical evidence is derived from the use of open-cell polyurethane foam at -125 mmHg. Alternative negative pressure systems are becoming available, which use gauze at a pressure of -80 mmHg. This study describes clinical results from a retrospective non comparative analysis of 30 patients treated with Chariker-Jeter gauze-based negative pressure systems (V1STA (TM), Versatile-1 (TM) and EZ-Care (TM); Smith & Nephew, Inc.) in a long-term care setting. The mean age of the patients was 72 years. The wounds consisted of chronic (n = 11), surgical dehiscence (n = 11) and surgical incision (n = 8). Wound volume and area were recorded at commencement and at the cessation of therapy. Discontinuation of therapy was instigated upon closure through secondary intention or when size and exudate were sufficiently reduced that the wounds could be managed by conventional wound dressing (median 41 days). An overall median reduction in wound volume of 88.0% (P < 0.001) and a 68.0% reduction in area (P < 0.001) compared with baseline were observed over the course of NPWT. The overall rate of volume reduction (15.1% per week) compares favourably with published data from foam-based systems.
C1 [Campbell, Penny E.] Smith & Nephew Inc, Wound Management, Largo, FL 33773 USA.
   [Smith, Gary S.] Smith & Nephew Inc, Stat & Data Management Grp, Kingston Upon Hull, N Humberside, England.
   [Smith, Jennifer M.] Smith & Nephew Inc, NPWT Strateg Business Unit, Kingston Upon Hull, N Humberside, England.
C3 Smith & Nephew; Smith & Nephew; Smith & Nephew
RP Campbell, PE (通讯作者)，Smith & Nephew Wound Management, Negat Pressure Wound Therapy, 11775 Starkey Rd, Largo, FL 33773 USA.
EM penny.campbell@smith-nephew.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 15
TC 60
Z9 68
U1 0
U2 8
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2008
VL 5
IS 2
BP 280
EP 286
DI 10.1111/j.1742-481X.2008.00485.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AW
UT WOS:000207843500016
PM 18494633
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Woo, KY
   Sibbald, RG
AF Woo, Kevin Y.
   Sibbald, R. Gary
TI Vacuum-assisted closure home care training: a process to link education
   to improved patient outcomes
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
ID PRESSURE WOUND THERAPY; DIABETIC FOOT ULCERS; MULTICENTER; DEBRIDEMENT;
   INHIBITOR; BEHAVIOR; TRIAL
AB Negative pressure wound therapy (NPWT) applies subatmospheric pressure across the wound bed inducing cellular and molecular changes that are beneficial to wound healing. This healing modality may facilitate tissue debridement, infection/inflammation control, and moisture balance; the key components of the wound bed preparation paradigm. To ensure that scientific evidence is diffused into daily clinical practice, we are proposing a knowledge transfer model that articulates an educational plan for the various levels of professional development. The discussion highlights the challenges and potential solutions to integrate NPWT into a seamless continuum of care including a community-based patient care model.
C1 [Woo, Kevin Y.; Sibbald, R. Gary] Womens Coll Hosp, Wound Healing Clin, Toronto, ON M5S 1B2, Canada.
   [Sibbald, R. Gary] Univ Toronto, Dept Publ Hlth Sci & Med, Toronto, ON, Canada.
C3 University of Toronto; Womens College Hospital; University of Toronto
RP Woo, KY (通讯作者)，Womens Coll Hosp, Wound Healing Clin, 76 Grenville St, Toronto, ON M5S 1B2, Canada.
EM kevin.woo@wchospital.ca
OI Sibbald, R Gary/0000-0002-6060-7272
FU Canadian Association of Wound Care; Coloplast; Smith and Nephew; 3M;
   KCI; Molnlycke; Covidien; Johnson Johnson
FX Kevin Woo was and is a Consultant/Advisor for Coloplast, Molnlycke, KCI,
   the Registered Nurses Association of Ontario and Merck. He is a member
   of the Speaker's Bureau for Johnson & Johnson, Coloplast and Molnlycke.
   Has and is receiving grant/research funding from the Canadian
   Association of Wound Care. R. Gary Sibbald is a Consultant/Advisor, a
   member of the Speaker's bureau and has and is receiving grant/research
   funding from Coloplast, Smith and Nephew, 3M, KCI, Molnlycke, Covidien
   and Johnson & Johnson.
CR Akbari A, 2007, J REHABIL RES DEV, V44, P631, DOI 10.1682/JRRD.2007.01.0002
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   [Anonymous], CHRONIC WOUND CARE C
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NR 41
TC 55
Z9 57
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2008
VL 5
SU 2
BP 1
EP 9
DI 10.1111/j.1742-481X.2008.00474.x
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AX
UT WOS:000207843600002
PM 17894663
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Wu, SC
   Armstrong, DG
AF Wu, Stephanie C.
   Armstrong, David G.
TI Clinical outcome of diabetic foot ulcers treated with negative pressure
   wound therapy and the transition from acute care to home care
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Diabetes; Lower extremity ulcer; Negative pressure wound therapy; VAC
   (R); Wound healing
AB Diabetic foot ulcers affect millions of people in the United States of America and impose tremendous medical, psychosocial and financial loss or burden. Negative pressure wound therapy (NPWT) is generally well tolerated and appears to stimulate a robust granulation tissue response compared with other wound healing modalities. This device may be a cost-effective adjunctive wound healing therapy. This literature review will focus on the clinical outcome of diabetic foot ulcers treated with NPWT, its implication in the transition from acute care to home care, factors that might influence clinical outcomes in home care as well as quality-of-life aspects in these patients. Patient care for diabetic foot ulceration is complex and necessitates multiprofessional collaboration to provide comprehensive wound care. It is clear that when we strive for limb preservation in this most high-risk population, it is important to have an available versatile, efficacious wound healing modality. There is a need for an easy transition from acute care to home care. Resources need to be combined in a collaborative and synergistic fashion to allow patient to perform many daily living activities while receiving the potential benefits of an advanced wound healing modality.
C1 [Wu, Stephanie C.; Armstrong, David G.] Rosalind Franklin Univ Med & Sci, Dr William M Scholl Coll Podiatr Med, Dept Surg, N Chicago, IL 60048 USA.
   [Wu, Stephanie C.; Armstrong, David G.] Rosalind Franklin Univ Med & Sci, Dr William M Scholl Coll Podiatr Med, CLEAR, N Chicago, IL 60048 USA.
   [Wu, Stephanie C.] Lutheran Gen Hosp, Advocate Med Grp, Natl Ctr Limb Salvage NCLP, Park Ridge, IL 60068 USA.
C3 Rosalind Franklin University of Medicine & Science; Rosalind Franklin
   University of Medicine & Science
RP Armstrong, DG (通讯作者)，Rosalind Franklin Univ Med & Sci, Dr William M Scholl Coll Podiatr Med, Dept Surg, 3333 Green Bay Rd, N Chicago, IL 60048 USA.
EM armstrong@usa.net
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NR 50
TC 26
Z9 30
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2008
VL 5
SU 2
BP 10
EP 16
DI 10.1111/j.1742-481X.2008.00466.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AX
UT WOS:000207843600003
PM 18577133
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Fife, CE
   Walker, D
   Thomson, B
   Otto, G
AF Fife, Caroline E.
   Walker, David
   Thomson, Brett
   Otto, Gordon
TI The safety of negative pressure wound therapy using vacuum-assisted
   closure in diabetic foot ulcers treated in the outpatient setting
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Adverse events; Chronic wounds; Negative pressure wound therapy; Safety;
   the VAC
AB The purpose of this project was to evaluate the safety of negative pressure wound therapy using the vacuum-assisted closure (V. A. C.(R)) Therapy System (KCI, San Antonio, TX) in diabetic foot ulcers (DFUs) among wound centre outpatients. We defined events that could represent complications or adverse events (AEs) as a result of treatment with the V. A. C., including symptoms of infection, pain, bleeding and periwound skin breakdown. The frequency of these AEs among V. A. C. patients with DFUs was compared with those among similar non V. A. C. patients. This project prospectively queried data collected during routine clinical care from 16 outpatient wound centres using the Intellicure electronic medical record system. The electronic recordswere de-identified according to HIPAA requirements and pooled to create a data repository dedicated to research (the Intellicure Research Consortium). Analysis was performed on 1331 DFUs representing 16 438 outpatient visits. A total of 1299 non V. A. C. and 72 V. A. C. DFUs were available for analysis. There was either no statistical difference between the AEs of V. A. C. versus non V. A. C. patients or the V. A. C. exerted a protective effect. We conclude that the V. A. C. is safe in outpatient use.
C1 [Fife, Caroline E.] Univ Texas Hlth Sci Ctr, Dept Anesthesiol, Houston, TX USA.
   [Walker, David; Thomson, Brett] Intellicure Inc, The Woodlands, TX USA.
   [Otto, Gordon] Univ N Carolina, Belk Coll Business Adm, Charlotte, NC 28223 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of North Carolina; University of North Carolina
   Charlotte
RP Fife, CE (通讯作者)，6431 Fannin,MSB 5-020, Houston, TX 77030 USA.
EM caroline.e.fife@uth.tmc.edu
FU KCI
FX This project was funded by KCI. Both Caroline Fife and David Walker hold
   stock in Intellicure and are major shareholders in Intellicure. Brett
   Thomson is a minor shareholder in Intellicure. Gordon Otto has declare
   no conflicts of interest.
CR Allman RM, 1997, CLIN GERIATR MED, V13, P421
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Barringer CB, 2004, BRIT J PLAST SURG, V57, P482, DOI 10.1016/j.bjps.2004.01.005
   Blume P., 2007, DIABETES CARE
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   *KCI, 2007, VAC THER CLIN GUID R
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NR 22
TC 12
Z9 16
U1 0
U2 9
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2008
VL 5
SU 2
BP 17
EP 22
DI 10.1111/j.1742-481X.2008.00467.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AX
UT WOS:000207843600004
PM 18577134
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Trueman, P
AF Trueman, Paul
TI Cost-effectiveness considerations for home health VAC® Therapy in the
   United States of America and its potential international application
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Economics; Home health; VAC Therapy
AB Vacuum-assisted closure (V.A.C.(R)) Therapy (KCI International, San Antonio, TX) has been widely used in hospital settings. However, use of V.A.C.(R) Therapy in home health settings outside of the United States of America (USA) is often limited because of financial considerations. This review paper considers the published evidence on V.A.C. Therapy in home health settings from the USA and beyond and explores the potential economic implications of V.A.C. Therapy in home health settings.
C1 Univ York, Hlth Econ Consortium, York YO10 5NH, N Yorkshire, England.
C3 University of York - UK
RP Trueman, P (通讯作者)，Univ York, Hlth Econ Consortium, York YO10 5NH, N Yorkshire, England.
EM pt507@york.ac.uk
FU KCI International
FX The author's department has previously received funding from KCI
   International to undertake research on V. A. C. Therapy. PT has not
   benefited personally from any funding from KCI International.
CR *DIAB FOOT INT DIA, POS STAT DIAB FOOT A
   Fisher A, 2003, ISSUES EMERGING HLTH
   HAMPTON S, 2005, J COMMUN NURS, V19, P27
   HAUSER T, 2007, ANN C GLASG EUR WOUN
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
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   XAKELLIS GC, COST HEALING PRESSUR
NR 12
TC 11
Z9 12
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2008
VL 5
SU 2
BP 23
EP 26
DI 10.1111/j.1742-481X.2008.00468.x
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AX
UT WOS:000207843600005
PM 18577135
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Gabriel, A
   Shores, J
   Heinrich, C
   Baqai, W
   Kalina, S
   Sogioka, N
   Gupta, S
AF Gabriel, Allen
   Shores, Jaimie
   Heinrich, Cherrie
   Baqai, Waheed
   Kalina, Sharon
   Sogioka, Norman
   Gupta, Subhas
TI Negative pressure wound therapy with instillation: a pilot study
   describing a new method for treating infected wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Instillation; Negative pressure wound therapy; Silver nitrate;
   Vacuum-assisted closure therapy; Wound-care infection
AB This data review reports the results of 15 patients who were treated with Vacuum-Assisted Closure (R) (VAC) negative pressure therapy system in addition to the timed, intermittent delivery of an instilled topical solution for management of their complex, infected wounds. Prospective data for 15 patients treated with negative pressure wound therapy (NPWT)-instillation was recorded and analysed. Primary endpoints were compared to a retrospective control group of 15 patients treated with our institution's standard moist wound-care therapy. Culture-specific systemic antibiotics were prescribed as per specific patient need in both groups. All data were checked for normality of distribution and equality of variance and appropriate parametric and non parametric analyses were conducted. Compared with the standard moist wound-care therapy control group, patients in the NPWT-instillation group required fewer days of treatment (36.5 +/- 13.1 versus 9.9 +/- 4.3 days, P < 0.001), cleared of clinical infection earlier (25.9 +/- 6.6 versus 6.0 +/- 1.5 days, P < 0.001), had wounds close earlier (29.6 +/- 6.5 versus 13.2 +/- 6.8 days, P < 0.001) and had fewer in-hospital stay days (39.2 +/- 12.1 versus 14. 7 +/- 9.2 days, P < 0.001). In this pilot study, NPWT instillation showed a significant decrease in the mean time to bioburden reduction, wound closure and hospital discharge compared with traditional wet-to-moist wound care. Outcomes from this study analysis suggest that the use of NPWT instillation may reduce cost and decrease inpatient care requirements for these complex, infected wounds.
C1 [Gabriel, Allen; Shores, Jaimie; Heinrich, Cherrie; Gupta, Subhas] Loma Linda Univ, Dept Plast Surg, Med Ctr, Loma Linda, CA 92354 USA.
   [Baqai, Waheed] Loma Linda Univ, Hlth Res Consulting Grp, Loma Linda, CA 92354 USA.
   [Kalina, Sharon; Sogioka, Norman] Kaiser Permanente, Kaiser Fdn Hosp, Dept Plast Surg, Fontana, CA USA.
C3 Loma Linda University; Loma Linda University; Kaiser Permanente
RP Gupta, S (通讯作者)，Loma Linda Univ, Dept Plast Surg, Med Ctr, 11175 Campus Dr,Coleman Pavil 21126, Loma Linda, CA 92354 USA.
EM sgupta@ahs.llumc.edu
RI ; Gupta, Subhas/C-5458-2018; Gabriel, Allen/AFK-3548-2022
OI Shores, Jaimie/0000-0002-4272-1389; Gupta, Subhas/0000-0001-5091-3922; 
FU KCI
FX The authors wish to thank Karen Beach, BS, for her editorial assistance
   (funded by KCI). Financial disclosures: Subhas Gupta, MD, PhD, FRCSC,
   FACS no financial interests or commercial associations; Allen Gabriel,
   MD is a member of the speakers bureau and clinical advisory panel of
   Kinetic Concepts, Inc.; the remaining authors have no financial
   interests or commercial associations.
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NR 64
TC 154
Z9 185
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2008
VL 5
IS 3
BP 399
EP 413
DI 10.1111/j.1742-481X.2007.00423.x
PG 15
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BA
UT WOS:000207843900005
PM 18593390
OA Green Submitted
DA 2026-07-24
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI Vacuum Assisted Closure: Recommendations for Use. A Consensus Document
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
ID PRESSURE WOUND THERAPY; MULTICENTER; ULCERS; TRIAL
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NR 30
TC 8
Z9 11
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP
PY 2008
VL 5
SU 4
BP 1
EP 19
PG 19
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BC
UT WOS:000207844100001
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Malmsjö, M
   Gesslein, B
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Gesslein, Bodil
   Ingemansson, Richard
TI Topical negative pressure effects on coronary blood flow in a sternal
   wound model
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Coronary blood flow; Poststernotomy mediastinitis; Topical negative
   pressure (TNP)
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; ENDOTHELIAL GROWTH-FACTOR;
   PERISTERNAL THORACIC WALL; ANGIOGENIC GENE-THERAPY; BYPASS
   GRAFT-SURGERY; RISK-FACTORS; CARDIAC-SURGERY; ARTERY-DISEASE;
   SHEAR-STRESS
AB Several studies have suggested that mediastinitis is a strong predictor for poor long-term survival after coronary artery bypass surgery (CABG). In those studies, several conventional wound-healing techniques were used. Previously, we have shown no difference in long-term survival between CABG patients with topical negative pressure (TNP)-treated mediastinitis and CABG patients without mediastinitis. The present study was designed to elucidate if TNP, applied over the myocardium, resulted in an increase of the total amount of coronary blood flow. Six pigs underwent median sternotomy. The coronary blood flow was measured, before and after the application of TNP (-50 mmHg), using coronary electromagnetic flow meter probes. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 minutes of LAD occlusion (ischaemic myocardium). Normal myocardium: 171.3 +/- 14.5 ml/minute before to 206.3 +/- 17.6 ml/minute after TNP application, P < 0.05. Ischaemic myocardium: 133.7 +/- 18.4 ml/minute before to 183.2 +/- 18.9 ml/minute after TNP application, P < 0.05. TNP of -50 mmHg applied over the LAD region induced a significant increase in the total coronary blood flow in both normal and ischaemic myocardium.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Heart & Lung Ctr, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
   [Malmsjo, Malin; Gesslein, Bodil] Univ Lund Hosp, Dept Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Heart & Lung Ctr, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Ingemansson,
   Richard/0000-0001-7623-8953; Maljö, Malin/0000-0001-9849-9599
FU Anders Otto Sward's Foundation/Ulrika Eklund's Foundation; Anna Lisa and
   Sven Eric Lundgren's Foundation for medical research; Angstromke Wiberg
   Foundation; M. Bergvall Foundation; Swedish Medical Association; Royal
   Physiographic Society in Lund; Swedish Medical Research Council;
   Crafoord Foundation; Swedish Heart-Lung Foundation; Swedish Government;
   Swedish Hypertension Society
FX We would like to thank Johan Ingemansson (Statistical Solutions IP) for
   his expert contribution to the statistic analyses. This study was
   supported by Anders Otto Sward's Foundation/Ulrika Eklund's Foundation,
   Anna Lisa and Sven Eric Lundgren's Foundation for medical research, the
   angstrom ke Wiberg Foundation, the M. Bergvall Foundation, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the
   Swedish Medical Research Council, the Crafoord Foundation, the Swedish
   Heart-Lung Foundation, the Swedish Government Grant for Clinical
   Research and the Swedish Hypertension Society.
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NR 43
TC 14
Z9 15
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2008
VL 5
IS 4
BP 503
EP 509
DI 10.1111/j.1742-481X.2008.00429.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BD
UT WOS:000207844200004
PM 19006573
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Bovill, E
   Banwell, PE
   Teot, L
   Eriksson, E
   Song, C
   Mahoney, J
   Gustafsson, R
   Horch, R
   Deva, A
   Whitworth, I
AF Bovill, Estas
   Banwell, Paul E.
   Teot, Luc
   Eriksson, Elof
   Song, Colin
   Mahoney, Jim
   Gustafsson, Ronny
   Horch, Raymund
   Deva, Anand
   Whitworth, Ian
CA Int Advisory Panel Topical
TI Topical negative pressure wound therapy: a review of its role and
   guidelines for its use in the management of acute wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Acute wound; Negative pressure wound therapy; Topical negative pressure
AB Over the past two decades, topical negative pressure (TNP) wound therapy has gained wide acceptance as a genuine strategy in the treatment algorithm for a wide variety of acute and chronic wounds. Although extensive experimental and clinical evidence exists to support its use and despite the recent emergence of randomised control trials, its role and indications have yet to be fully determined. This article provides a qualitative overview of the published literature appertaining to the use of TNP therapy in the management of acute wounds by an international panel of experts using standard methods of appraisal. Particular focus is applied to the use of TNP for the open abdomen, sternal wounds, lower limb trauma, burns and tissue coverage with grafts and dermal substitutes. We provide evidence-based recommendations for indications and techniques in TNP wound therapy and, where studies are insufficient, consensus on best practice.
C1 [Banwell, Paul E.] Queen Victoria Hosp, Dept Plast & Reconstruct Surg, E Grinstead RH19 3DZ, W Sussex, England.
   [Bovill, Estas] Derriford Hosp, Dept Plast & Reconstruct Surg, Plymouth PL6 8DH, Devon, England.
   [Teot, Luc] Montpellier Univ Hosp, Dept Plast & Burns Surg, Montpellier, France.
   [Eriksson, Elof] Harvard Univ, Sch Med, Div Plast Surg, Boston, MA USA.
   [Eriksson, Elof] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Song, Colin] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 0316, Singapore.
   [Mahoney, Jim] Univ Toronto, Div Plast Surg, Toronto, ON, Canada.
   [Gustafsson, Ronny] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Horch, Raymund] Univ Hosp Erlangen, Dept Plast & Hand Surg, Erlangen, Germany.
   [Deva, Anand] Univ New S Wales, Dept Plast & Reconstruct Surg, Sydney, NSW, Australia.
   [Whitworth, Ian] Salisbury Dist Hosp, Salisbury, Wilts, England.
C3 Derriford Hospital; Universite de Montpellier; CHU de Montpellier;
   Harvard University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Singapore
   General Hospital; University of Toronto; Lund University; Skane
   University Hospital; University of Erlangen Nuremberg; University of New
   South Wales Sydney; Salisbury District Hospital
RP Banwell, PE (通讯作者)，Queen Victoria Hosp, Dept Plast & Reconstruct Surg, Holtye Rd, E Grinstead RH19 3DZ, W Sussex, England.
EM paul.banwell@qvh.nhs.uk
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353; Deva, Anand/0000-0002-0314-7177
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NR 125
TC 85
Z9 100
U1 3
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2008
VL 5
IS 4
BP 511
EP 529
DI 10.1111/j.1742-481X.2008.00437.x
PG 19
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BD
UT WOS:000207844200005
PM 18808432
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Derrick, KL
   Norbury, K
   Kieswetter, K
   Skaf, J
   McNulty, AK
AF Derrick, Kathleen L.
   Norbury, Kenneth
   Kieswetter, Kris
   Skaf, Jihad
   McNulty, Amy K.
TI Comparative analysis of global gene expression profiles between diabetic
   rat wounds treated with vacuum-assisted closure therapy, moist wound
   healing or gauze under suction
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Diabetic; Gene expression; Microarray; VAC; Wound healing
ID FOOT; REPAIR; AMPUTATION; RESPONSES
AB How differential gene expression affects wound healing is not well understood. In this study, Zucker diabetic fatty (fa/fa) male inbred rats were used to investigate gene expression during wound healing in an impaired wound-healing model. Whole genome microarray surveys were used to gain insight into the biological pathways and healing processes in acute excisional wounds treated with vacuum-assisted closure (V.A.C.(R)) Therapy, moist wound healing (MWH) or gauze under suction (GUS). Global gene expression analyses after 2 days of healing indicated major differences with respect to both number of genes showing fold changes and pathway regulation between the three different wound treatments. Statistical analysis of expression profiles indicated that 5072 genes showed a >1.6-fold change with V. A. C. Therapy compared with 3601 genes with MWH and 3952 genes with GUS. Pathways and related genes associated with the early phases of wound healing diverged between treatment groups. For example, pathways involving angiogenesis, cytoskeletal regulation and inflammation were associated with elevated gene expression following V. A. C. Therapy. This study is the first to assess wound healing by whole genome interrogation in a diabetic rat model treated with different healing modalities.
C1 [Derrick, Kathleen L.; Norbury, Kenneth; Kieswetter, Kris; McNulty, Amy K.] Kinet Concepts Inc, San Antonio, TX USA.
   [Skaf, Jihad] Appl Biosyst Inc, Foster City, CA 94404 USA.
C3 Thermo Fisher Scientific; Applied Biosystems
RP Derrick, KL (通讯作者)，Kinet Concepts Inc, 6203 Farinon Dr, San Antonio, TX USA.
EM kathleen.derrick@kci1.com
FU Kinetic Concepts Inc (KCI)
FX We thank Barbara Collins, Crissy Jenschke, Lisa Hartson and Leslie
   Sanchez for animal work and providing tissue samples. Financial support
   - Kinetic Concepts, Inc; KLD, KN, KK and AKM are used at Kinetic
   Concepts Inc (KCI). JS is employed at Applied Biosystems Inc.
CR ANDROS G, 2006, OSTOMY WOUND MANAG, V18, pS1
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NR 44
TC 24
Z9 35
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2008
VL 5
IS 5
BP 615
EP 624
DI 10.1111/j.1742-481X.2008.00544.x
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BF
UT WOS:000207844400005
PM 19134062
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Wild, T
   Stremitzer, S
   Budzanowski, A
   Hoelzenbein, T
   Ludwig, C
   Ohrenberger, G
AF Wild, Thomas
   Stremitzer, Stefan
   Budzanowski, Annita
   Hoelzenbein, Thomas
   Ludwig, Claudia
   Ohrenberger, Gerald
TI Definition of efficiency in vacuum therapy - a randomised controlled
   trial comparing Redon drains with VAC® Therapy™
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Pressure ulcer; Redon bottles; Vacuum-assisted closure (VAC)
AB Redon drains are still used to suction wounds for vacuum sealing. Vacuum-assisted closure (V.A.C.(R); Kinetic Concepts Inc, San Antonio, TX) is a computer-controlled therapy system for delivering topical negative pressure therapy. The efficiency of V. A. C. in the treatment of pressure ulcers was prospectively studied in a randomised controlled trial in which patients with pressure ulcers were randomly assigned to negative pressure wound therapy (NPWT) using either V. A. C. or Redon bottles. The target parameters were absolute and relative proportion of wound area consists of granulation tissue, fibrin and necrosis. Other outcome measures were the number of dressing changes and time invested using each system. The study was terminated after a post hoc analysis after inclusion of ten patients because of the significantly better results when using V. A. C., and the substantially larger care effort needed in the Redon group compared with the V. A. C. group. An increase in surface granulation tissue of 54% was observed in the V. A. C. group, and a reduction in the Redon group (P = 0.001). The Redon group showed an increase in fibrin tissue at the wound base of 21.8%, whereas in the V. A. C group, a 27% reduction was observed (P = 0.035). Necrosis was reduced in the V. A. C. group, but this difference did not reach significance. Redon bottles are not a good alternative for V. A. C. therapy for delivering NPWT.
C1 [Wild, Thomas; Stremitzer, Stefan; Budzanowski, Annita] Med Univ Vienna, Dept Gen Surg, A-1090 Vienna, Austria.
   [Hoelzenbein, Thomas] Med Univ Vienna, Dept Vasc Surg, A-1090 Vienna, Austria.
   [Ludwig, Claudia; Ohrenberger, Gerald] Geriatr Ctr Haus der Barmherzigkeit, Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna
RP Wild, T (通讯作者)，Med Univ Vienna, Dept Gen Surg, Spitalgasse 23, A-1090 Vienna, Austria.
EM thomas.wild@meduniwien.ac.at
FU National Grant OENBF [10865]
FX This project was supported by National Grant OENBF 10865.
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NR 26
TC 24
Z9 32
U1 0
U2 9
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2008
VL 5
IS 5
BP 641
EP 647
DI 10.1111/j.1742-481X.2007.00407.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BF
UT WOS:000207844400008
PM 19134065
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Fitzgerald, RH
   Bharara, M
   Mills, JL
   Armstrong, DG
AF Fitzgerald, Ryan H.
   Bharara, Manish
   Mills, Joseph L.
   Armstrong, David G.
TI Use of a Nanoflex powder dressing for wound management following
   debridement for necrotising fasciitis in the diabetic foot
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Wound healing; Diabetic foot; Nanoparticle; Dressing; Nanotechnology
AB This paper discusses the application of Nanoflex powder dressing for management of complex soft tissue wounds. A case report is presented detailing the management of a 43-year-old Native American woman with diabetes mellitus who required serial debridements for necrotising fasciitis. Following debridement, the patient was left with a large dorsal foot wound and was transitioned through multiple advanced wound healing modalities. Negative pressure wound therapy (NPWT) was initially utilised in the early postoperative setting to control drainage and to promote granulation tissue; the patient was subsequently transitioned to a Nanoflex powder dressing on postoperative day 4. She reported a decrease in pain associated with dressing changes when transitioned from NPWT to the use of Nanoflex powder dressing. We hypothesise that this pain reduction is the result of a light cooling effect of the exudate-controlling dressing and subsequent reduction in inflammation as well as the total contact nature of the dressing. Nanoflex powder dressings are a recently developed advanced wound healing modality with promise in the management of complex soft tissue wounds, both as a primary wound dressing as well as a delivery platform for analgesics, antimicrobials and pro-angiogenic compounds.
C1 [Fitzgerald, Ryan H.; Bharara, Manish; Mills, Joseph L.; Armstrong, David G.] Univ Arizona, Coll Med, Dept Surg, Tucson, AZ 85724 USA.
C3 University of Arizona
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, Dept Surg, 1501 N Campbell Ave, Tucson, AZ 85724 USA.
EM armstrong@usa.net
RI Mills, Joseph/L-2023-2019
OI Mills, Joseph/0000-0002-4955-4384
CR [Anonymous], 2004, WOUNDS, p3S
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NR 21
TC 19
Z9 20
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2009
VL 6
IS 2
BP 133
EP 139
DI 10.1111/j.1742-481X.2009.00596.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BT
UT WOS:000207845800006
PM 19432662
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Witkowski, W
   Jawien, A
   Witkiewicz, W
   Zon, B
AF Witkowski, Wojciech
   Jawien, Arkadiusz
   Witkiewicz, Wojciech
   Zon, Bartlomiej
TI Initial multi-centre observations upon the effect of a new topical
   negative pressure device upon patient and clinician experience and the
   treatment of wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Topical negative pressure; TNP; Negative pressure wound therapy; NPWT;
   Wound management
AB Topical Negative Pressure (TNP) has become an accepted intervention in wound healing with a growing body of scientific literature supporting the effectiveness of TNP across a wide variety of wound aetiologies. The range of TNP devices has also increased with perhaps the primary distinction being between those TNP devices that employ gauze or foam as a wound dressing. This study reports preliminary multi-centre observations upon the use of a new gauze based TNP device in the treatment of wounds. Across 3 study centres twenty-nine subjects were recruited to the study with 8 presenting with leg ulcers, 8 with pressure ulcers, 12 with acute or surgical wounds and 1 with a non-healing burn injury. Wounds were then treated with the new TNP therapy for a maximum of 17 days (range 2-17 days). There appeared to be a trend for subjects with leg ulcers to be treated for longer (mean duration 12.9 days) compared to subjects with pressure ulcers (mean duration 6.5 days) or those with surgical wounds (mean duration 8.2 days). Given the relatively short duration of the TNP therapy no wound completely healed although 22/29 (75.9%) showed reductions in surface area per day of treatment with all but 1 pressure ulcer and 1 leg ulcer responding positively to treatment. While not an RCT, this and similar cohort studies may be central to the future selection of TNP devices given the increasing importance of the role of the user interface to reduce the likelihood of incorrect use and sub-optimal outcomes.
C1 [Witkowski, Wojciech; Zon, Bartlomiej] Mil Inst Hlth Serv, Plast Reconstruct Surg & Burn Management Dept, Warsaw, Poland.
   [Jawien, Arkadiusz] Reg Specialist Hosp, Bydgoszcz, Poland.
   [Witkiewicz, Wojciech] Reg Specialist Hosp, Wroclaw, Poland.
RP Witkowski, W (通讯作者)，Mil Inst Hlth Serv, Plast Reconstruct Surg & Burn Management Dept, Warsaw, Poland.
EM wojwit@wim.mil.pl
RI Jawien, Arkadiusz/L-1475-2014
OI Jawien, Arkadiusz/0000-0001-8380-9371
CR [Anonymous], BEDSORE BIOMECHANICS
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NR 8
TC 11
Z9 23
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2009
VL 6
IS 2
BP 167
EP 174
DI 10.1111/j.1742-481X.2009.00586.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BT
UT WOS:000207845800011
PM 19432667
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Stevens, P
AF Stevens, Philip
TI Vacuum-assisted closure of laparostomy wounds: a critical review of the
   literature
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Laparostomy; Open abdomen; Temporary abdominal closure; Topical negative
   pressure; Vacuum-assisted closure
ID ABDOMINAL COMPARTMENT SYNDROME; TOPICAL NEGATIVE-PRESSURE; OPEN ABDOMEN;
   FASCIAL CLOSURE; VENTRAL HERNIA; TRAUMA; EXPERIENCE; THERAPY
AB Vacuum-assisted closure (VAC) reduces the burden for carers of laparostomy wounds but evidence from randomised trials is lacking. This review analyses the evidence for the VAC (R) abdominal wound management system (KCI, San Antonio, TX) in the open abdomen. Three prospective studies provide level III evidence that VAC (R) allows delayed primary fascial closure in the majority of these wounds up to 21 days after occurrence, but not where duration of VAC (R) was less than 9 days or if vacuum pack techniques were used in place of VAC (R). Fistulae occurred in a minority of wounds complicated by multi-organ failure or sepsis and could not be attributed to VAC (R) itself. Two retrospective analyses suggested VAC (R) may reduce re-operation rate and length of stay in complex wounds. Whilst randomised controlled trials remain the gold standard of evidence for effectiveness of health care interventions, contemporaneous level III evidence supports the hypothesis that VAC (R) increases the rate of primary fascial closure. Whilst enterocutaneous fistula formation is reported in the most complex of these wounds, there is no more evidence that these are consequential to as opposed to coincident with VAC (R) use.
C1 Nevill Hall Hosp, Dept Gen Surg, Abergavenny NP7 7EG, Gwent, Wales.
RP Stevens, P (通讯作者)，Nevill Hall Hosp, Dept Gen Surg, Brecon Rd, Abergavenny NP7 7EG, Gwent, Wales.
EM Stevens_P1@hotmail.com
CR [Anonymous], CORE TOPICS GEN EMER
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NR 51
TC 56
Z9 61
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2009
VL 6
IS 4
BP 259
EP 266
DI 10.1111/j.1742-481X.2009.00614.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BW
UT WOS:000207846100002
PM 19719522
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Gabriel, A
   Shores, J
   Bernstein, B
   de Leon, J
   Kamepalli, R
   Wolvos, T
   Baharestani, MM
   Gupta, S
AF Gabriel, Allen
   Shores, Jaimie
   Bernstein, Brent
   de Leon, Jean
   Kamepalli, Ravi
   Wolvos, Tom
   Baharestani, Mona M.
   Gupta, Subhas
TI A Clinical Review of Infected Wound Treatment with Vacuum Assisted
   Closure® (VAC®) Therapy: Experience and Case Series
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE negative pressure wound therapy; NPWT; VAC (R) Therapy System; Vacuum
   Assisted Closure (R); infected wound care
ID IN-VITRO MODEL; NEGATIVE-PRESSURE; ANTIMICROBIAL RESISTANCE;
   ANTIBIOTIC-RESISTANCE; VAC(TM) INSTILLATION; BACTERIAL BIOBURDEN; TISSUE
   INHIBITOR; BED PREPARATION; SILVER; BIOFILMS
AB Over the last decade Vacuum Assisted Closure (R) (KCI Licensing, Inc., San Antonio, TX) has been established as an effective wound care modality for managing complex acute and chronic wounds. The therapy has been widely adopted by many institutions to treat a variety of wound types. Increasingly, the therapy is being used to manage infected and critically colonized, difficult-to-treat wounds. This growing interest coupled with practitioner uncertainty in using the therapy in the presence of infection prompted the convening of an interprofessional expert advisory panel to determine appropriate use of the different modalities of negative pressure wound therapy (NPWT) as delivered by V.A.C.(R) Therapy and V.A.C. Instill (R) with either GranuFoam (TM) or GranuFoam Silver (TM) Dressings. The panel reviewed infected wound treatment methods within the context of evidence-based medicine coupled with experiential insight using V.A.C.(R) Therapy Systems to manage a variety of infected wounds. The primary objectives of the panel were 1) to exchange state-of-practice evidence, 2) to review and evaluate the strength of existing data, and 3) to develop practice recommendations based on published evidence and clinical experience regarding use of the V.A.C.(R) Therapy Systems in infected wounds. These recommendations are meant to identify which infected wounds will benefit from the most appropriate V.A.C.(R) Therapy System modality and provide an infected wound treatment algorithm that may lead to a better understanding of optimal treatment strategies.
C1 [Gabriel, Allen; Shores, Jaimie; Gupta, Subhas] Loma Linda Univ, Sch Med, Dept Plast Surg, Loma Linda, CA 92354 USA.
   [Bernstein, Brent] St Lukes Hosp, Bethlehem, PA USA.
   [de Leon, Jean] Baylor Specialty Hosp, Dallas, TX USA.
   [Kamepalli, Ravi] Reg Infect Dis Infus Ctr, Lima, OH USA.
   [Wolvos, Tom] Scottsdale Healthcare Hosp, Scottsdale, AZ USA.
   [Baharestani, Mona M.] James H Quillen Vet Affairs Med Ctr, Johnson City, TN USA.
   [Baharestani, Mona M.] E Tennessee State Univ, Johnson City, TN 37614 USA.
C3 Loma Linda University; Scottsdale Healthcare Osborn; East Tennessee
   State University
RP Gupta, S (通讯作者)，Loma Linda Univ, Sch Med Coleman, Dept Plast Surg, Pavil 21126 11175 Campus St, Loma Linda, CA 92354 USA.
EM sgupta@llu.edu
RI Gabriel, Allen/AFK-3548-2022; /AAQ-9524-2020; Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922; Shores, Jaimie/0000-0002-4272-1389
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NR 129
TC 53
Z9 65
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2009
VL 6
SU 2
BP 1
EP 25
DI 10.1111/j.1742-481X.2009.00628.x
PG 25
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BX
UT WOS:000207846200001
PM 19811550
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Baharestani, M
   Amjad, I
   Bookout, K
   Fleck, T
   Gabriel, A
   Kaufman, D
   McCord, SS
   Moores, DC
   Olutoye, OO
   Salazar, JD
   Song, DH
   Teich, S
   Gupta, S
AF Baharestani, Mona
   Amjad, Ibrahim
   Bookout, Kim
   Fleck, Tatjana
   Gabriel, Allen
   Kaufman, David
   McCord, Shannon Stone
   Moores, Donald C.
   Olutoye, Oluyinka O.
   Salazar, Jorge D.
   Song, David H.
   Teich, Steven
   Gupta, Subhas
TI VAC® Therapy in the management of paediatric wounds: clinical review and
   experience
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; NPWT; VAC Therapy; Vacuum-assisted
   closure; Paediatric wound care; Abdominal compartment syndrome;
   astroschisis
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; SECURING
   SKIN-GRAFTS; OPEN CELL FOAM; SPINAL-FUSION; SUBATMOSPHERIC PRESSURE;
   ENTEROCUTANEOUS FISTULA; POSTOPERATIVE INFECTIONS; TEMPORARY TREATMENT;
   PILONIDAL DISEASE
AB Usage of negative pressure wound therapy (NPWT) in the management of acute and chronic wounds has grown exponentially in the past decade. Hundreds of studies have been published regarding outcomes and methods of therapy used for adult wounds. This treatment is increasingly being used to manage difficult-to-treat paediatric wounds arising from congenital defects, trauma, infection, tumour, burns, pressure ulceration and postsurgical complications in children, although relatively few studies have been aimed at this population. Given the anatomical and physiological differences between adults and children, a multidisciplinary expert advisory panel was convened to determine appropriate use of NPWT with reticulated open cell foam (NPWT/ROCF) as delivered by Vacuum Assisted Closure (R) (V.A.C.(R) Therapy, KCI Licensing, Inc., San Antonio, TX) for the treatment of paediatric wounds.
   The primary objectives of the expert advisory panel were to exchange state-of-practice information on paediatric wound care, review the published data regarding the use of NPWT/ROCF in paediatric wounds, evaluate the strength of the existing data and establish guidelines on best practices with NPWT/ROCF for the paediatric population. The proposed paediatrics-specific clinical practice guidelines are meant to provide practitioners an evidence base from which decisions could be made regarding the safe and efficacious selection of pressure settings, foam type, dressing change frequency and use of interposing contact layer selections. The guidelines reflect the state of knowledge on effective and appropriate wound care at the time of publication. They are the result of consensus reached by expert advisory panel members based on their individual clinical and published experiences related to the use of NPWT/ROCF in treating paediatric wounds. Best practices are described herein for novice and advanced users of NPWT/ROCF. Recommendations by the expert panel may not be appropriate for use in all circumstances. Decisions to adopt any particular recommendation must be made by the collaborating medical team, including the surgeon and wound care specialist based on available resources, individual patient circumstances and experience with the V.A.C.(R) Therapy System.
C1 [Baharestani, Mona] E Tennessee State Univ, Ctr Nursing Res, Johnson City, TN 37614 USA.
   [Bookout, Kim] Childrens Med Ctr, Dallas, TX 75235 USA.
   [Fleck, Tatjana] Med Univ Vienna, Dept Cardiothorac Surg, Vienna, Austria.
   [Gabriel, Allen; Gupta, Subhas] Loma Linda Univ, Sch Med, Dept Plast Surg, Loma Linda, CA USA.
   [Kaufman, David] Univ Virginia, Sch Med, Dept Pediat, Charlottesville, VA 22908 USA.
   [Kaufman, David] Univ Virginia, Sch Med, Div Neonatol, Charlottesville, VA 22908 USA.
   [McCord, Shannon Stone] Texas Childrens Hosp, Houston, TX 77030 USA.
   [Moores, Donald C.] Loma Linda Univ, Childrens Hosp, Div Pediat Surg, Loma Linda, CA 92350 USA.
   [Olutoye, Oluyinka O.] Baylor Coll Med, Dept Surg, Houston, TX 77030 USA.
   [Salazar, Jorge D.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
   [Song, David H.] Univ Chicago Hosp, Pritzker Sch Med, Sect Plast Surg, Chicago, IL 60637 USA.
   [Teich, Steven] Childrens Hosp Columbus, Dept Surg, Columbus, OH USA.
C3 East Tennessee State University; Medical University of Vienna; Loma
   Linda University; University of Virginia; University of Virginia; Baylor
   College of Medicine; Baylor College Medical Hospital; Children's
   Hospital Los Angeles; Loma Linda University; Baylor College of Medicine;
   University of Texas System; University of Texas at San Antonio;
   University of Illinois System; University of Chicago; University of
   Chicago Medical Center; University System of Ohio; Ohio State
   University; Nationwide Childrens Hospital
RP Baharestani, M (通讯作者)，E Tennessee State Univ, Ctr Nursing Res, Roy Nicks Hall,Off 1-112, Johnson City, TN 37614 USA.
EM baharest@etsu.edu
RI Gabriel, Allen/AFK-3548-2022; Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922
FU AACN VAC; KCI; Hutchinson Technologies, Inc; Kinetic Concepts, Inc.
FX S.M. is the primary investigator on a AACN VAC research grant.
   Additional funding has been provided by KCI. O.O. has received grant
   funding from the following companies for the named research projects:
   Hutchinson Technologies, Inc: "Assessing gut oxygenation in premature
   infants using near infrared spectroscopy" and Kinetic Concepts, Inc.
   "Negative Pressure Wound Therapy".
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NR 153
TC 59
Z9 87
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2009
VL 6
SU 1
BP 1
EP 26
DI 10.1111/j.1742-481X.2009.00607.x
PG 26
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16CB
UT WOS:000207846600001
PM 19614789
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU de Leon, JM
   Barnes, S
   Nagel, M
   Fudge, M
   Lucius, A
   Garcia, B
AF de Leon, Jean M.
   Barnes, Sunni
   Nagel, Melody
   Fudge, Michelle
   Lucius, Adora
   Garcia, Betty
TI Cost-effectiveness of Negative Pressure Wound Therapy for Postsurgical
   Patients in Long-term Acute Care
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
AB OBJECTIVES: To evaluate the cost-effectiveness of negative pressure wound therapy (NPWT) using reticulated open-cell foam (NPWT/ROCF) as delivered by a Vacuum-Assisted Closure* (KCI Licensing, Inc, San Antonio, Texas) in patients with complex wounds in a long-term acute care (LTAC) setting. These patients are routinely discharged to LTAC hospitals with the goal of accelerating wound healing and timely transfer to a lower acuity care setting and are usually affected with serious comorbidities and deep, complex wounds with exposed anatomical structures, which require extended care (stay > 25 days).
   DESIGN: A retrospective chart review was conducted to determine the average daily wound volume reduction, average daily wound area reduction, and average cost per cubic centimeter of wound volume reduction for patients treated with NPWT/ROCF as compared with topical advanced moist healing strategies (non-NPWT).
   SETTING: All patients received treatment in an LTAC hospital.
   PARTICIPANTS: Patients admitted from November 2001 to August 2004 were identified using a computerized hospital database. The inclusion criteria were postsurgical patients of at least 18 years of age, with a single acute wound.
   INTERVENTION: Patients were treated with either NPWT/ROCF or advanced moist wound-healing therapies (non-NPWTs).
   MEASUREMENTS: Data collected included age, sex, wound measurements, Bates-Jensen Wound Assessment Tool severity score, procedures performed, wound care products and devices used, wound-healing outcomes, and costs associated with treatment.
   RESULTS: Fifty-one patients met the inclusion criteria: 36 were identified as NPWT/ROCF and 15 as non-NPWT. The NPWT/ROCF patients showed a statistically significantly higher average daily rate of volume reduction as compared with the advanced moist wound-healing group (5.02 +/- 13.36 vs 0.40 +/- 0.88 cm(3)/day; P = .046). The cost per cubic centimeter reduction was $11.90/cm(3) in the NPWT/ROCF group versus $30.92/cm(3) in the moist wound-healing group.
   CONCLUSION: Postsurgical LTAC patients who were treated by NPWT/ROCF had a more accelerated rate of wound closure, compared with patients treated with advanced moist wound-healing therapy. These results suggest that, for this patient group, NPWT/ROCF may be more clinically effective in reducing wound volume, compared with advanced moist wound healing. Furthermore, the lower cost per cubic centimeter volume reduction suggests that NPWT/ROCF produces a more favorable cost-effective solution. Therefore, it is important when developing a wound-healing strategy that cost decisions be based on overall cost and not individual product cost when using advanced technology as part of the overall treatment plan. This study serves as a basis for further work in cost-benefit analysis when considering evidence-based outcomes in wound care. ADV SKIN WOUND CARE 2009; 22: 122 - 7
C1 [de Leon, Jean M.] Baylor Specialty Hosp Wound Care & Outpatient Wou, Dallas, TX 75246 USA.
   [Barnes, Sunni] Baylor Hlth Care Syst, Dallas, TX USA.
   [Nagel, Melody] Baylor Specialty Hosp Wound Care, Dallas, TX USA.
   [Fudge, Michelle; Lucius, Adora; Garcia, Betty] Baylor Specialty Hosp, Dallas, TX USA.
C3 Baylor Scott & White Health
RP de Leon, JM (通讯作者)，Baylor Specialty Hosp Wound Care & Outpatient Wou, Dallas, TX 75246 USA.
FU KCI Licensing, Inc.
FX Institutional review board approval was obtained through the Baylor
   Specialty Hospital to perform this study. This study is sponsored by a
   research grant from KCI Licensing, Inc. *All trademarks and service
   marks designated concerning Vacuum-Assisted Closure are proprietary of
   KCI Licensing, Inc, San Antonio, Texas, its affiliates, and licensors.
CR [Anonymous], CROSS QUAL CHASM NEW
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NR 21
TC 30
Z9 34
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAR
PY 2009
VL 22
IS 3
BP 122
EP 127
DI 10.1097/01.ASW.0000305452.79434.d9
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA V19SE
UT WOS:000208091300005
PM 19247013
DA 2026-07-24
ER
PT J
AU Kaplan, M
   Daly, D
   Stemkowski, S
AF Kaplan, Mark
   Daly, Darron
   Stemkowski, Stephen
TI Early Intervention of Negative Pressure Wound Therapy Using
   Vacuum-Assisted Closure in Trauma Patients: Impact on Hospital Length of
   Stay and Cost
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
ID MULTICENTER; MANAGEMENT
AB OBJECTIVE: The cost of treating complex traumatic wounds is substantial because of trauma severity, potential for infection, and delayed closure. Negative pressure wound therapy using reticulated open cell foam (NPWT/ROCF) as delivered by Vacuum-Assisted Closure* (KCI Licensing, Inc, San Antonio, Texas) is an established, viable option for treating traumatic wounds. The authors used retrospective data to study the clinical and cost-effective benefits of using NPWT/ROCF early on day 1 or day 2 of treatment for traumatic wounds as compared with using it late (on day 3 or later).
   METHODS: Hospital data records from trauma wound patients treated with NPWT/ROCF were retrospectively analyzed. Data were subdivided into 2 groups based on start of treatment. The group of patients treated on day 1 or 2 of their hospital stay was referred to as the early group, and that composed of patients treated on day 3 or later as the late group. Clinical and cost-effective metrics were compared between the 2 groups.
   RESULTS: For the early group, 518 patient records were included; 1000 records were reviewed for the late group. Early-group patients had fewer hospital inpatient days (10.6 vs 20.6 days; P < .0001), fewer treatment days (5.1 vs 6.0 days; P = .0498), shorter intensive care unit (ICU) stays (5.3 vs 12.4 days; P < .0001), and higher ICU admission rates (51.5 vs 44.5%; P = .0091) than the late group. Compared with late-group patients, early-group patients had lower total and variable costs per patient discharge ($43,956 vs $32,175; P < .0001 and $22,891 vs $15,805; P < .0001, respectively).
   CONCLUSION: Acute-care trauma wound patients receiving early NPWT/ROCF demonstrated significant reductions in length of stay, treatment days, and ICU stay, which resulted in significant reduced patient treatment costs. These results indicate that early intervention with NPWT/ROCF has potential clinical and cost-effective benefits for the treatment of traumatic wounds. ADV SKIN WOUND CARE 2009; 22: 128 - 32
C1 [Kaplan, Mark] Albert Einstein Med Ctr, Div Trauma & Surg Crit Care, Philadelphia, PA 19141 USA.
   [Daly, Darron] Kinet Concepts Inc, N Amer Profess Affairs, San Antonio, TX USA.
   [Stemkowski, Stephen] Premier Inc, Premier Res Serv, Charlotte, NC USA.
C3 Yeshiva University; Premier, Inc.
RP Kaplan, M (通讯作者)，Albert Einstein Med Ctr, Div Trauma & Surg Crit Care, Philadelphia, PA 19141 USA.
FU KCI Licensing, Inc.; KCI USA, Inc, San Antonio, Texas
FX Article sponsored by an educational grant from KCI Licensing, Inc.This
   study was supported by a grant from KCI USA, Inc, San Antonio, Texas.
   Editorial assistance was provided by Karen Beach and Julissa Ramos. *All
   trademarks and service marks designated herein are proprietary of KCI
   Licensing, Inc, its affiliates, and licensors.
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NR 20
TC 53
Z9 65
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAR
PY 2009
VL 22
IS 3
BP 128
EP 132
DI 10.1097/01.ASW.0000305451.71811.d5
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA V19SE
UT WOS:000208091300006
PM 19247014
DA 2026-07-24
ER
PT J
AU Milleret, V
   Bittermann, AG
   Mayer, D
   Hall, H
AF Milleret, Vincent
   Bittermann, Anne Greet
   Mayer, Dieter
   Hall, Heike
TI Analysis of Effective Interconnectivity of DegraPol-foams Designed for
   Negative Pressure Wound Therapy
SO MATERIALS
LA English
DT Article
DE Degrapol (R); polymer foams; pore interconnectivity; Negative Pressure
   Wound Therapy (NPWT)
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; MEMBRANES;
   COPOLYESTERS; HYDROGEL; GRAFTS
AB Many wounds heal slowly and are difficult to manage. Therefore Negative Pressure Wound Therapy (NPWT) was developed where polymer foams are applied and a defined negative pressure removes wound fluid, reduces bacterial burden and increases the formation of granulation tissue. Although NPWT is used successfully, its mechanisms are not well understood. In particular, different NPWT dressings were never compared. Here a poly-ester urethane Degrapol (R) (DP)-foam was produced and compared with commercially available dressings (polyurethane-based and polyvinyl-alcohol-based) in terms of apparent pore sizes, swelling and effective interconnectivity of foam pores. DP-foams contain relatively small interconnected pores; PU-foams showed large pore size and interconnectivity; whereas PVA-foams displayed heterogeneous and poorly interconnected pores. PVA-foams swelled by 40 %, whereas DP- and PU-foams remained almost without swelling. Effective interconnectivity was investigated by submitting fluorescent beads of 3, 20 and 45 mu m diameter through the foams. DP- and PU-foams removed 70-90 % of all beads within 4 h, independent of the bead diameter or bead pre-adsorption with serum albumin. For PVA-foams albumin pre-adsorbed beads circulated longer, where 20 % of 3 mu m and 10 % of 20 mu m diameter beads circulated after 96 h. The studies indicate that efficient bead perfusion does not only depend on pore size and swelling capacity, but effective interconnectivity might also depend on chemical composition of the foam itself. In addition due to the efficient sieve-effect of the foams uptake of wound components in vivo might occur only for short time suggesting other mechanisms being decisive for success of NPWT.
C1 [Milleret, Vincent; Hall, Heike] Swiss Fed Inst Technol, Dept Mat, Zurich, Switzerland.
   [Bittermann, Anne Greet] Univ Zurich, Ctr Microscopy & Imaging Anal, ZMB, CH-8006 Zurich, Switzerland.
   [Mayer, Dieter] Univ Zurich Hosp, CH-8091 Zurich, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; University of
   Zurich; University of Zurich; University Zurich Hospital
RP Hall, H (通讯作者)，Swiss Fed Inst Technol, Dept Mat, Zurich, Switzerland.
EM vincent.milleret@mat.ethz.ch; agb@access.unizh.ch; dieter.mayer@usz.ch;
   heike.hall@mat.ethz.ch
RI Mayer, Dieter/E-7617-2011
FU ab-medica, Lainate, Italy
FX The authors would like to thank D-MATL ETH-Zurich tool shop for
   excellent technical help in production of the flow device and ab-medica,
   Lainate, Italy for a fellowship for V. M.
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NR 41
TC 8
Z9 10
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1996-1944
J9 MATERIALS
JI Materials
PD MAR
PY 2009
VL 2
IS 1
BP 292
EP 306
DI 10.3390/ma2010292
PG 15
WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy &
   Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering;
   Physics
GA V20KS
UT WOS:000208139500014
OA Green Submitted, Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Riss, S
   Stift, A
   Meier, M
   Haiden, E
   Grünberger, T
   Bergmann, M
AF Riss, S.
   Stift, A.
   Meier, M.
   Haiden, E.
   Gruenberger, T.
   Bergmann, M.
TI Endo-sponge assisted treatment of anastomotic leakage following
   colorectal surgery
SO COLORECTAL DISEASE
LA English
DT Article
DE Rectal surgery; anastomotic leakage; endo-sponge; vacuum assisted
   closure
AB Aim Endo-sponge assisted treatment (endo-sponge) represents a novel approach to treat patients with anastomotic dehiscence following anterior resection for rectal cancer. Yet, limited data are available to predict success, compatibility with radiotherapy and/or chemotherapy as well as acceptance by the patients.
   Method Between September 2007 and June 2008, nine patients suffering from anastomotic leakage after anterior rectal resection (n = 6) or suffering from leakage of rectal stump following Hartmann's procedure (n = 3) were treated by endo-sponge. We recorded clinical outcome and patient's comfort using a 10-point visual analogue scale (VAS).
   Results Median time of endo-sponge treatment was 3 weeks (range: 2-8). There were no minor or major complications. In 6 (66.6%) patients, the anastomotic leakage healed successfully. Three patients showed no response and needed further surgical intervention. The lack of success was due to complexity of the leakages, which comprised either more than 270 degrees of the circumference or consisted of two distant fistulas. Formation of granulation tissue was unaffected by chemotherapy. For the question 'alteration in daily life activity', a median score of 5 (range: 1-9) was found. Measuring 'pain sensation' during endo-sponge treatment patients scored a median of 3 (range: 0-6).
   Conclusions Endo-sponge treatment can be recommended as an alternative approach to treat pelvic sepsis following anastomotic dehiscence or rectal stump insufficiency. Extended leakages should be treated by different approaches having little probability of successful healing, but can lead to discomfort for the patient. Radiochemotherapy does not cause a problem for application of the endo-sponge.
C1 [Bergmann, M.] Med Univ Vienna, Dept Surg, Div Gen Surg, A-1090 Vienna, Austria.
C3 Medical University of Vienna
RP Bergmann, M (通讯作者)，Med Univ Vienna, Dept Surg, Div Gen Surg, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM michael.bergmann@meduniwien.ac.at
RI Gruenberger, Thomas/ABA-1661-2020; Bergmann, Michael/GZK-7700-2022
OI Gruenberger, Thomas/0000-0002-2671-0540; Stift,
   Anton/0000-0002-7243-8138; Bergmann, Michael/0000-0001-8529-1166
CR BAKKER FC, 1982, BJS-BRIT J SURG, V69, P580, DOI 10.1002/bjs.1800691007
   Branagan G, 2005, DIS COLON RECTUM, V48, P1021, DOI 10.1007/s10350-004-0869-4
   GALLOT D, 1992, ANN CHIR, V46, P491
   Glitsch A, 2008, ENDOSCOPY, V40, P192, DOI 10.1055/s-2007-995384
   Jech B, 2007, EUR SURG, V39, P8, DOI 10.1007/s10353-007-0312-x
   Lee WS, 2008, WORLD J SURG, V32, P1124, DOI 10.1007/s00268-007-9451-2
   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nagell CF, 2006, INT J COLORECTAL DIS, V21, P657, DOI 10.1007/s00384-005-0083-4
   Nesbakken A, 2001, BRIT J SURG, V88, P400, DOI 10.1046/j.1365-2168.2001.01719.x
   PAKKASTIE TE, 1994, EUR J SURG, V160, P293
   PAKKASTIE TE, 1994, EUR J SURG, V160, P299
   Rullier E, 1998, BRIT J SURG, V85, P355
   SCHEIN M, 1993, AM J SURG, V165, P285, DOI 10.1016/S0002-9610(05)80528-8
   Schintler MV, 2008, EUR SURG, V40, P11, DOI 10.1007/s10353-008-0381-5
   Van Koperen PJ, 2008, COLORECTAL DIS, V10, P943, DOI 10.1111/j.1463-1318.2008.01485.x
   Van Koperen PJ, 2008, SURG ENDOSC IN PRESS
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 18
TC 35
Z9 41
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JUL
PY 2010
VL 12
IS 7
BP E104
EP E108
DI 10.1111/j.1463-1318.2009.01885.x
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA V23PY
UT WOS:000208355900016
PM 19508536
DA 2026-07-24
ER
PT J
AU Birnbaum, DJ
   D'Journo, XB
   Casanova, D
   Thomas, PA
AF Birnbaum, David J.
   D'Journo, Xavier Benoit
   Casanova, Dominique
   Thomas, Pascal A.
TI Necrotizing fasciitis of the chest wall
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Necrotizing fasciitis; Chest wall; Group A beta-haemolytic
   streptococcus; Vacuum-assisted closure
AB Necrotizing fasciitis (NF) is an uncommon infection caused by microorganisms called `flesh eating bacteria'. It remains a life-threatening condition associated with high mortality rate. Its location to the chest wall is exceptional. Herein, we report the case of a 39-year-old female, without comorbidity, presenting a NF of the chest wall complicating an empyema. We describe the surgical management with a three-step procedure: antibiotherapy-debridement, vacuum-assisted closure and delayed surgical reconstruction. (C) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 Univ Mediterranean, Dept Thorac Surg, Hop St Marguerite, Marseille, France.
   Assistance Publ Hop Marseille, Marseille, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille
RP Thomas, PA (通讯作者)，CHU Sud, Dept Chirurg Thorac & Malad Oesophage, Hop St Marguerite, 270 Bd Ste Marguerite, F-13274 Marseille 9, France.
EM Pascal-alexandre.Thomas@mail.ap-hm.fr
RI D'journo, Xavier Benoit/AAJ-4457-2021; Birnbaum, David/Z-1563-2019;
   Thomas, Pascal/L-3355-2019
OI D'journo, Xavier Benoit/0000-0001-6747-4583; Thomas,
   Pascal/0000-0002-3305-6989
CR Barbosa RF, 2006, MICROSURG, V26, P519, DOI 10.1002/micr.20280
   Kalkat M S, 2003, Interact Cardiovasc Thorac Surg, V2, P358, DOI 10.1016/S1569-9293(03)00050-1
   Konstantinov IE, 2008, ANN THORAC SURG, V86, P1973, DOI 10.1016/j.athoracsur.2008.05.004
   Safran DB, 2001, ANN THORAC SURG, V72, P1362, DOI 10.1016/S0003-4975(00)02588-1
   Urschel JD, 1997, ANN THORAC SURG, V64, P276, DOI 10.1016/S0003-4975(97)00514-6
NR 5
TC 11
Z9 12
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD MAR
PY 2010
VL 10
IS 3
BP 483
EP 484
DI 10.1510/icvts.2009.222323
PG 2
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA V25LY
UT WOS:000208480700049
PM 20019031
OA Bronze
DA 2026-07-24
ER
PT J
AU Ugaki, S
   Kasahara, S
   Arai, S
   Takagaki, M
   Sano, S
AF Ugaki, Shinya
   Kasahara, Shingo
   Arai, Sadahiko
   Takagaki, Masami
   Sano, Shunji
TI Combination of continuous irrigation and vacuum-assisted closure is
   effective for mediastinitis after cardiac surgery in small children
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Mediastinitis; Pediatric; Congenital heart defects
AB There is still no consensus on the optimal management to treat pediatric mediastinitis. We assessed the efficacy of continuous irrigation and vacuum-assisted closure (VAC) for mediastinitis in children. This study retrospectively reviewed 20 patients aged <5 years with mediastinitis from December 2002 to December 2009. The median age at the onset was 12 months (0.6-60 months), and the median body weight was 6.9 kg (3.1-15.3 kg). Continuous irrigation was applied for extensive mediastinitis or unstable hemodynamic cases and VAC for localized or ineffective cases after continuous irrigation. A 2-4-week course of intravenous antibiotics was administered after sternal closure. Continuous irrigation was initially applied in 19 patients and VAC in one patient. VAC was employed in six patients because of recurrent or prolonged mediastinitis after continuous irrigation. All patients underwent direct sternal closure without any flap. The median duration of the hospital stay was 49.5 days (15-158 days). Although two patients died of low cardiac output, 18 children survived and had no recurrence after the discharge during a median follow-up of 14 months (1-81 months). The combination of continuous irrigation and VAC is, therefore, considered to be a safe and effective option to minimize the morbidity and mortality in pediatric mediastinitis. (C) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Ugaki, Shinya; Kasahara, Shingo; Arai, Sadahiko; Takagaki, Masami; Sano, Shunji] Okayama Univ, Okayama Univ Hosp, Dept Cardiovasc Surg, Grad Sch Med & Dent, Okayama 7008558, Japan.
C3 Okayama University
RP Ugaki, S (通讯作者)，Okayama Univ, Okayama Univ Hosp, Dept Cardiovasc Surg, Grad Sch Med & Dent, 2-5-1 Shikata, Okayama 7008558, Japan.
EM uga-strah@hotmail.co.jp
RI Kasahara, Shingo/B-2207-2011
CR Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Fleck Tatjana, 2006, Interact Cardiovasc Thorac Surg, V5, P285, DOI 10.1510/icvts.2005.122424
   Hiramatsu T, 2008, ASIAN CARDIOVASC THO, V16, P45
   Kadohama T, 2008, ANN THORAC SURG, V85, P1094, DOI 10.1016/j.athoracsur.2007.09.004
   Kirsch M, 2001, ANN THORAC SURG, V71, P1580, DOI 10.1016/S0003-4975(01)02452-3
   Luckraz H, 2003, J THORAC CARDIOV SUR, V125, P301, DOI 10.1067/mtc.2003.74
   Merrill WH, 2004, ANN THORAC SURG, V78, P608, DOI 10.1016/j.athoracsur.2004.02.089
   Petzina R, 2007, J THORAC CARDIOV SUR, V133, P1154, DOI 10.1016/j.jtcvs.2007.01.011
   SHUMACKER HB, 1963, ARCH SURG-CHICAGO, V86, P384
   Steigelman MB, 2009, ANN THORAC SURG, V88, P1277, DOI 10.1016/j.athoracsur.2009.06.027
   THURER RJ, 1974, J THORAC CARDIOV SUR, V68, P962
   Tortoriello TA, 2003, ANN THORAC SURG, V76, P1655, DOI 10.1016/S0003-4975(03)01025-7
NR 12
TC 18
Z9 20
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD SEP
PY 2010
VL 11
IS 3
BP 247
EP 251
DI 10.1510/icvts.2010.235903
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA V25MR
UT WOS:000208482600010
PM 20442210
OA Bronze
DA 2026-07-24
ER
PT J
AU Grauhan, O
   Navarsadyan, A
   Hussmann, J
   Hetzer, R
AF Grauhan, Onnen
   Navarsadyan, Artashes
   Hussmann, Juergen
   Hetzer, Roland
TI Infectious erosion of aorta ascendens during vacuum-assisted therapy of
   mediastinitis
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Vacuum-assisted therapy; Vacuum-assisted closure; Negative pressure
   wound therapy; Mediastinitis; Aortic erosion
AB Sternal wound infection is a potentially life-threatening complication after cardiac surgery. With the vacuum-assisted closure (VAC) system a relatively new treatment option is available, with encouraging results and few complications. However, fatal right ventricular rupture for mechanical reasons has been reported. We report the case of a 34-year-old patient with life-threatening bleeding due to infectious erosion of the aorta ascendens during VAC therapy of mediastinitis after cardiac surgery. To the best of our knowledge, this is the first reported case of infectious erosion (i.e. not VAC-related) of cardiovascular structures during running vacuum-assisted therapy. (C) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Grauhan, Onnen; Navarsadyan, Artashes; Hussmann, Juergen; Hetzer, Roland] Deutsch Herzzentrum Berlin, D-13353 Berlin, Germany.
C3 German Heart Center Berlin
RP Grauhan, O (通讯作者)，Deutsch Herzzentrum Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM grauhan@dhzb.de
CR Bapat V, 2008, J CARDIAC SURG, V23, P227, DOI 10.1111/j.1540-8191.2008.00595.x
   Cowan KN, 2005, ANN THORAC SURG, V80, P2205, DOI 10.1016/j.athoracsur.2005.04.005
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   Jones G, 1997, ANN SURG, V225, P766, DOI 10.1097/00000658-199706000-00014
   Kirkby KA, 2009, COMPENDIUM, V31, P568
   Luckraz H, 2003, J THORAC CARDIOV SUR, V125, P301, DOI 10.1067/mtc.2003.74
   Malmsjö M, 2009, J THORAC CARDIOV SUR, V138, P712, DOI 10.1016/j.jtcvs.2008.11.068
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Yasuura K, 1998, ANN SURG, V227, P455, DOI 10.1097/00000658-199803000-00019
NR 9
TC 10
Z9 12
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD OCT
PY 2010
VL 11
IS 4
BP 493
EP 494
DI 10.1510/icvts.2010.238105
PG 2
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA V25MU
UT WOS:000208482900028
PM 20573649
OA Bronze
DA 2026-07-24
ER
PT J
AU Assenza, M
   Valesini, L
   Monacelli, G
   Simonelli, L
   Antoniozzi, A
   Ferrazza, GC
   Usai, V
   Romeo, V
   Modini, C
AF Assenza, M.
   Valesini, L.
   Monacelli, G.
   Simonelli, L.
   Antoniozzi, A.
   Ferrazza, G. C.
   Usai, V.
   Romeo, V.
   Modini, C.
TI Traumatic complex wounds, multidisciplinary approach: our experience in
   a case series
SO CLINICA TERAPEUTICA
LA English
DT Article
DE damage control; PRP gel; traumatic complex wound; VAC therapy
AB "Limb-salvage" is a social problem that is rapidly increasing, both in Italy and in the rest of world. Today, as in earlier times, the main causes of open wounds are traumas and such injuries are mainly of II and III stage of Gustilo's classification. Nowadays, the use of modern techniques determined a further dramatic reduction in the infection rates and, above all, in the risk of limb amputation. The most important techniques include: V. A. C. therapy (vacuum assisted closure); PRP gel (platelet-rich plasma gel); hyperbaric oxygen therapy. We treated 4 patients with high energy acute trauma through the combined and innovative use of advanced dressings. The authors report their experience and a brief review of the literature as contribution in regards to treatment of complex wounds of the limbs.
C1 [Assenza, M.; Valesini, L.; Monacelli, G.; Simonelli, L.; Antoniozzi, A.; Usai, V.; Romeo, V.; Modini, C.] Sapienza Univ Roma, Dipartiment Chirurg Urgenza & Trauma, Rome, Italy.
   [Ferrazza, G. C.] Sapienza Univ Roma, Dipartiment Ematol Oncol Immunoematol & Med Rigen, Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome
RP Assenza, M (通讯作者)，Sapienza Univ Roma, Policlin Umberto I, Dipartimento Chirurg Urgenza & Trauma, Rome, Italy.
EM marco.assenza@uniroma1.it
RI ; ASSENZA, Marco/LLK-2745-2024
OI ferrazza, giancarlo/0000-0003-3483-900X; ASSENZA,
   Marco/0000-0002-0400-5410
CR DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
   Kazakos K, 2009, INJURY, V40, P801, DOI 10.1016/j.injury.2008.05.002
   LALLISS SJ, 2007, ANN M ORTH TRAUM ASS
   McNulty AK, 2007, WOUND REPAIR REGEN, V15, P838, DOI 10.1111/j.1524-475X.2007.00287.x
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Pape HC, 2008, J ORTHOP TRAUMA, V22, pS133, DOI 10.1097/BOT.0b013e318188e26b
   Pollak AN, 2008, J ORTHOP TRAUMA, V22, pS142, DOI 10.1097/BOT.0b013e318188e2a9
   Rozman P, 2007, ACTA DERMATOVEN ALP, V16, P156
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
NR 11
TC 2
Z9 2
U1 0
U2 1
PU SOC EDITRICE UNIV
PI ROME
PA VIA G B MORGAGNI 1, ROME, 10061, ITALY
SN 0009-9074
EI 1972-6007
J9 CLIN TER
JI Clin. Ter.
PD MAY-JUN
PY 2010
VL 161
IS 3
SU S
BP E95
EP E99
PG 5
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA V28ZK
UT WOS:000208718500003
PM 20589349
DA 2026-07-24
ER
PT J
AU Walls, B
   Mohammad, S
   Campbell, J
   Archer, L
   Beale, J
AF Walls, B.
   Mohammad, S.
   Campbell, J.
   Archer, L.
   Beale, J.
TI Negative pressure dressings for severe hidradenitis suppurativa (acne
   inversa): a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hidradenitis suppurativa; negative pressure wound therapy
AB Hidradenitis suppurativa (HS) is a frustrating disease to treat for both the patient and the practitioner. In severe cases, aggressive management will often have a more tolerable outcome. We present the case of a 46-year-old gentleman with a long-standing history of severe HS, who was treated successfully with wide surgical excision, followed by a full-thickness skin graft and negative pressure wound therapy (both pre- and post-operatively). A review of the literature revealed few reports of HS treatment using these sequential steps
C1 [Walls, B.; Mohammad, S.; Campbell, J.; Archer, L.; Beale, J.] HCA Largo Med Ctr, Wound Care Ctr, Largo, FL USA.
RP Walls, B (通讯作者)，HCA Largo Med Ctr, Wound Care Ctr, Largo, FL USA.
EM blissy79@comcast.net
CR Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Buimer MG, 2009, BRIT J SURG, V96, P350, DOI 10.1002/bjs.6569
   Dyson M., 2004, CHRONIC WOUND CARE P
   Elwood ET, 2001, ANN PLAS SURG, V46, P49, DOI 10.1097/00000637-200101000-00010
   Fardet L, 2007, J AM ACAD DERMATOL, V56, P624, DOI 10.1016/j.jaad.2006.07.027
   HARRISON BJ, 1987, BMJ-BRIT MED J, V294, P487, DOI 10.1136/bmj.294.6570.487
   Hynes PJ, 2002, BRIT J PLAST SURG, V55, P507, DOI 10.1054/bjps.2002.3899
   Kagan RJ, 2005, SURGERY, V138, P734, DOI 10.1016/j.surg.2005.06.053
   Kurzen H, 2008, EXP DERMATOL, V17, P455, DOI [10.1111/j.1600-0625.2008.00712_1.x, 10.1111/j.1600-0625.2008.00712.x]
   Revuz J, 2009, J EUR ACAD DERMATOL, V23, P985, DOI 10.1111/j.1468-3083.2009.03356.x
   Shah N, 2005, AM FAM PHYSICIAN, V72, P1547
   Shuster S, 2008, BRIT J DERMATOL, V158, P1, DOI 10.1111/j.1365-2133.2007.08282.x
   Soldin MG, 2000, BRIT J PLAST SURG, V53, P434, DOI 10.1054/bjps.1999.3285
   van der Zee HH, 2010, J AM ACAD DERMATOL, V63, P475, DOI 10.1016/j.jaad.2009.12.018
   von der Werth J.M., 2001, DERMATOLOGY PRACTICE, V9, p[3, 22]
   Von der Werth JM, 2000, BRIT J DERMATOL, V142, P947, DOI 10.1046/j.1365-2133.2000.03476.x
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   Wolff K., 2005, FITZPATRICKS COLOR A, VFifth
NR 19
TC 5
Z9 8
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2010
VL 19
IS 10
BP 457
EP 460
DI 10.12968/jowc.2010.19.10.79094
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA V29CP
UT WOS:000208726800008
PM 20948495
DA 2026-07-24
ER
PT J
AU Xie, X
   McGregor, M
   Dendukuri, N
AF Xie, X.
   McGregor, M.
   Dendukuri, N.
TI The clinical effectiveness of negative pressure wound therapy: a
   systematic review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE wound treatment; negative pressure; pressure ulcers; diabetic ulcers;
   trial quality
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; PROSPECTIVE
   RANDOMIZED-TRIAL; MANAGEMENT; MULTICENTER
AB EObjective: To estimate the efficacy of negative pressure wound therapy (NPWT), on the basis of a systematic review of reported randomised controlled trials (RCTs).
   Method: A systematic literature search for relevant RCTs was carried out. The credibility of the outcome of each study was evaluated using a specially constructed instrument.
   Results: We identified 17 RCTs, of which five had not been included in previous reviews or health technology assessments. For diabetic foot ulcers (seven RCTs), there was consistent evidence of the benefit of NPWT compared with control treatments. For pressure ulcers (three RCTs), results were conflicting. In trials involving mixed wounds (five RCTs), evidence was encouraging but of inadequate quality. Significant complications were not increased.
   Conclusion: There is now sufficient evidence to show that NPWT is safe, and will accelerate healing, to justify its use in the treatment of diabetes-associated chronic leg wounds. There is also evidence, though of poor quality, to suggest that healing of other wounds may also be accelerated.
C1 [Xie, X.] McGill Univ, Ctr Hlth, Technol Assessment Unit, Montreal, PQ, Canada.
   [McGregor, M.] McGill Univ, Ctr Hlth, Technol Assessment Unit, Univ Hlth Ctr,Dept Med & Chair, Montreal, PQ, Canada.
   [Dendukuri, N.] McGill Univ, Ctr Hlth, Technol Assessment Unit, Univ Hlth Ctr, Montreal, PQ, Canada.
   [McGregor, M.] McGill Univ, Div Cardiovasc, Univ Hlth Ctr, Technol Assessment Unit,Dept Med,Dept Med & Chair, Montreal, PQ, Canada.
   [Dendukuri, N.] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Univ Hlth Ctr, Technol Assessment Unit, Montreal, PQ, Canada.
C3 McGill University; McGill University; McGill University; McGill
   University; McGill University
RP Xie, X (通讯作者)，McGill Univ, Ctr Hlth, Technol Assessment Unit, Montreal, PQ, Canada.
EM maurice.mcgregor@mcgill.ca
CR Akbari A, 2007, J REHABIL RES DEV, V44, P631, DOI 10.1682/JRRD.2007.01.0002
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   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Atkins D, 2004, BMJ-BRIT MED J, V328, P1490
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   Costa V., 2007, VACCUM ASSISTED WOUN
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NR 36
TC 68
Z9 70
U1 0
U2 13
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2010
VL 19
IS 11
BP 488
EP 493
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA V29CQ
UT WOS:000208726900005
DA 2026-07-24
ER
PT J
AU Stansby, G
   Wealleans, V
   Wilson, L
   Morrow, D
   Gooday, C
   Dhatariya, K
AF Stansby, G.
   Wealleans, V.
   Wilson, L.
   Morrow, D.
   Gooday, C.
   Dhatariya, K.
TI Clinical experience of a new NPWT system in diabetic foot ulcers and
   post-amputation wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE wound pain; wound healing; amputation
ID GREAT TOE AMPUTATION; PRESSURE; THERAPY; MULTICENTER
AB Objective: The primary aim of this pilot observational study was to assess the reduction in wound depth and area achieved with a new negative pressure wound therapy (NPWT) system in diabetic patients with foot ulcers and post-amputation wounds. Secondary aims were to assess pain levels, extent of exudate removal, and ease of use of the system for both the patient and care giver.
   Method: Patients in both acute and home care settings were enrolled into this 4-week study. Dressings were changed three times per week. Wound area and depth, exudate removal and pain severity were evaluated at each dressing change. At the final visit, the investigators and patients were surveyed with respect to equipment and dressings used in the study.
   Results: Sixteen patients were enrolled into the study. Data relating to 14 patients with a variety of post-amputation wounds were included in the intention-to-treat (ITT) analysis. The post-amputation wounds showed a general trend for a reduction in the median wound surface area between baseline (22.9cm(2); range 0.5-55) and the final visit (15.3cm(2); range 2.4-63.5). This equates to a median change (calculated from the percentage change in wound area for each patient individually) of -41% (range -82% to + 15%). There was also a general trend in reduction in the median depth between baseline (17mm; range 0-35) to final visit (5mm; range 0-35). One patient presented with a foot ulcer that demonstrated a 50% reduction in depth from baseline to the final assessment. The device effectively managed wound exudate and most patients reported low pain levels during therapy. Ease of use of the system was rated very highly by investigators and patients.
   Conclusion: This pilot study indicates that the use of the new NPWT system can be expected to have a positive effect on the healing of post-amputation wounds and foot ulcers in patients with diabetes. The findings demonstrate that the system is easy to use, effectively controls exudate and minimises pain and inconvenience for patients being treated with NPWT.
C1 [Stansby, G.; Wealleans, V.; Wilson, L.] Freeman Rd Hosp, Newcastle Upon Tyne, Tyne & Wear, England.
   [Morrow, D.; Gooday, C.; Dhatariya, K.] Norfolk & Norwich Univ Hosp, Norwich, Norfolk, England.
C3 Newcastle Freeman Hospital; Newcastle University - UK; Norfolk & Norwich
   University Hospitals NHS Foundation Trust; Norfolk & Norwich University
   Hospital
RP Stansby, G (通讯作者)，Freeman Rd Hosp, Newcastle Upon Tyne, Tyne & Wear, England.
EM Gerard.stansby@nuth.nhs.uk
OI Gooday, Catherine/0000-0001-5026-6788; Stansby,
   Gerard/0000-0001-5539-3049
FU Molnlycke Heath Care (Gothenburg, Sweden); Medela AG (Baar, Switzerland)
FX This study was sponsored by Molnlycke Heath Care (Gothenburg, Sweden)
   and Medela AG (Baar, Switzerland). The authors have no other conflicts
   of interest that are directly relevant to the content of this
   manuscript.
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NR 22
TC 16
Z9 20
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2010
VL 19
IS 11
BP 496
EP 502
DI 10.12968/jowc.2010.19.11.79706
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA V29CQ
UT WOS:000208726900006
PM 21135798
DA 2026-07-24
ER
PT J
AU Beitz, JM
   van Rijswijk, L
AF Beitz, Janice M.
   van Rijswijk, Lia
TI Content Validation of Algorithms to Guide Negative Pressure Wound
   Therapy in Adults with Acute or Chronic Wounds: A Cross-sectional Study
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE wounds; algorithms; negative pressure wound therapy; validation studies;
   patient safety
ID CARE ALGORITHMS; MANAGEMENT; VACUUM
AB Despite extensive use of negative pressure wound therapy (NPWT) and reported patient safety concerns, evidence-based algorithms to guide its safe and appropriate use in various wounds have only recently been developed. Preliminary content validity was established using literature review and expert-based face validity with a small sample of experts (N = 12). To examine the content validity of this set of three NPWT algorithms and to enhance understanding about previously identified wound terminology issues, a cross-sectional, mixed-methods, quantitative study was conducted among wound experts. The paper/pencil survey instrument consisted of the algorithms, a demographic questionnaire, and request to provide definitions of five commonly used terms: acute wound, chronic wound, and primary, secondary, and tertiary intention healing. A Likert scale (range 1 to 4) was included to rate the relevance of each of the 34 unique steps/statements/decision points contained in the algorithms, and space was provided to comment on each component. Convenience-sampling methods were used in three different settings: an international professional wound care meeting; a regional wound, ostomy, continence (WOC) nurses meeting; and an urban university with a suburban satellite campus. Of the 190 wound care experts invited to participate, 114 accepted. Participants' average age was 48 (range 23 to 68) years, and most were registered nurses (72%) practicing in the United States (94%).
   The content validity of the NPWT components was strong, with an overall mean rating of 3.76 (SD = 0.56, range 3.49 to 3.92; very relevant/appropriate, relevant/appropriate). The overall content validity index for the 5,696 responses received was 0.96 (range 0.88 to 1.0). Qualitative themes included comments about wound terminology and definitions, the presentation of the central algorithm, reading level, helpfulness/ease of use, the use of color, and information placement in the algorithm document.
   Some consensus on wound definitions was observed, but results also confirmed that important disparities in mutual understanding of what constitutes acute versus chronic wounding remain. Commonly used surgical closure definitions of primary, secondary, tertiary intention also were not clearly or correctly understood by a substantial number of participants. These NPWT algorithms are the first evidence-based, content-validated algorithms developed for a variety of acute and chronic wounds in adult patients. Future research is needed to test whether they facilitate safe patient care in clinical practice
C1 [Beitz, Janice M.] Rutgers State Univ, Sch Nursing Camden, Camden, NJ 08102 USA.
   [van Rijswijk, Lia] Holy Family Univ, Sch Nursing & Allied Hlth Profess, Philadelphia, PA USA.
   [van Rijswijk, Lia] Ostomy Wound Management, Malvern, PA USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Camden
RP Beitz, JM (通讯作者)，Rutgers State Univ, Sch Nursing Camden, 407 Armitage Hall,311 North 5th St, Camden, NJ 08102 USA.
EM Janice.beitz@camden.rutgers.edu
RI vanRijswijk, Lia/LZF-6639-2025
FU ConvaTec (Skillman, NJ)
FX This study was supported by a research grant from ConvaTec (Skillman,
   NJ). The study was conducted, the data analyzed, and the manuscript
   written by the authors who are responsible for the content, of this
   publication. The authors do not have a financial interest in any of the
   products discussed in this publication.
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NR 51
TC 5
Z9 8
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD SEP
PY 2012
VL 58
IS 9
BP 32
EP 40
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA V30TQ
UT WOS:000208838700006
PM 22933699
DA 2026-07-24
ER
PT J
AU Neiderer, K
   Martin, B
   Hoffman, S
   Jolley, D
   Dancho, J
AF Neiderer, Katherine
   Martin, Billy
   Hoffman, Steven
   Jolley, David
   Dancho, James
TI A Mechanically Powered Negative Pressure Device Used in Conjunction with
   a Bioengineered Cell-based Product for the Treatment of Pyoderma
   Gangrenosum: A Case Report
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case report; pyoderma gangrenosum; negative-pressure wound therapy;
   artificial skin; wounds
AB Pyoderma gangrenosum (PG), an uncommon inflammatory and ulcerative skin disease, typically is treated medically with a combination of immunosuppression and local wound care, but evidence to guide care is limited. PG wounds can be difficult to heal. A 76-year-old male patient presented with a history of rheumatoid arthritis and recalcitrant PG. After 9 months of treatment with local wound care, steroids, and topical tacrolimus, the wound had increased in size from 1.8 cm x 1.5 cm to, 7.2 cm x 5.6 cm. At that time, he was started on a regimen of five applications of a bioengineered cell-based product (one application every 2 weeks for a total of five applications) with twice-weekly mechanically powered negative pressure device changes. The latter was started at 75 mm Hg and changed to 125 mm Hg after 4 weeks, Oral corticosteroid therapy was initially started at 40 mg of prednisone, then slowly tapered to 20 mg, but could not be completely discontinued due to a flare in the patient's rheumatoid symptoms. The wound was completely healed after 16 weeks. Research to ascertain the effectiveness of protocols of PG care, including the combination treatment described, is needed to help clinicians provide evidence-based care for these challenging wounds.
C1 [Neiderer, Katherine; Martin, Billy; Hoffman, Steven; Jolley, David; Dancho, James] Southern Arizona VA Hlth Care Syst, Tucson, AZ 85723 USA.
   [Neiderer, Katherine] Univ Arizona, Tucson, AZ USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Southern Arizona Veterans Affairs Health Care System; University of
   Arizona
RP Neiderer, K (通讯作者)，Southern Arizona VA Hlth Care Syst, Dept Surg, 3601 South 6th Ave 2-112, Tucson, AZ 85723 USA.
EM kateneiderer@hotmail.com
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NR 24
TC 15
Z9 15
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD SEP
PY 2012
VL 58
IS 9
BP 44
EP 48
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA V30TQ
UT WOS:000208838700007
PM 22933700
DA 2026-07-24
ER
PT J
AU Fowler, JR
   Kleiner, MT
   Das, R
   Gaughan, JP
   Rehman, S
AF Fowler, J. R.
   Kleiner, M. T.
   Das, R.
   Gaughan, J. P.
   Rehman, S.
TI Assisted closure of fasciotomy wounds A DESCRIPTIVE SERIES AND CAUTION
   IN PATIENTS WITH VASCULAR INJURY
SO BONE & JOINT RESEARCH
LA English
DT Article
DE Fasciotomy; Negative pressure wound therapy; NPWT; Vessel loop closure;
   Infection; Complications
AB Introduction
   Negative pressure wound therapy (NPWT) and vessel loop assisted closure are two common methods used to assist with the closure of fasciotomy wounds. This retrospective review compares these two methods using a primary outcome measurement of skin graft requirement.
   Methods
   A retrospective search was performed to identify patients who underwent fasciotomy at our institution. Patient demographics, location of the fasciotomy, type of assisted closure, injury characteristics, need for skin graft, length of stay and evidence of infection within 90 days were recorded.
   Results
   A total of 56 patients met the inclusion criteria. Of these, 49 underwent vessel loop closure and seven underwent NPWT assisted closure. Patients who underwent NPWT assisted closure were at higher risk for requiring skin grafting than patients who underwent vessel loop closure, with an odds ratio of 5.9 (95% confidence interval 1.11 to 31.24). There was no difference in the rate of infection or length of stay between the two groups. Demographic factors such as age, gender, fracture mechanism, location of fasciotomy and presence of open fracture were not predictive of the need for skin grafting.
   Conclusion
   This retrospective descriptive case series demonstrates an increased risk of skin grafting in patients who underwent fasciotomy and were treated with NPWT assisted wound closure. In our series, vessel loop closure was protective against the need for skin grafting. Due to the small sample size in the NPWT group, caution should be taken when generalising these results. Further research is needed to determine if NPWT assisted closure of fasciotomy wounds truly leads to an increased requirement for skin grafting, or if the vascular injury is the main risk factor.
C1 [Fowler, J. R.; Kleiner, M. T.; Das, R.; Gaughan, J. P.; Rehman, S.] Temple Univ Hosp & Med Sch, Philadelphia, PA 19140 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University
RP Fowler, JR (通讯作者)，Temple Univ Hosp & Med Sch, 3401 N Broad St, Philadelphia, PA 19140 USA.
EM john.fowler@tuhs.temple.edu
RI Fowler, John/D-4849-2016
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NR 24
TC 16
Z9 20
U1 0
U2 1
PU BRITISH EDITORIAL SOC BONE JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2046-3758
J9 BONE JOINT RES
JI Bone Jt. Res.
PD MAR
PY 2012
VL 1
IS 3
BP 31
EP 35
DI 10.1302/2046-3758.13.2000022
PG 5
WC Cell & Tissue Engineering; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Orthopedics
GA V35GW
UT WOS:000209139400002
PM 23610668
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wong, R
   Melnyk, M
   Tang, SS
   Nguan, C
AF Wong, Rachel
   Melnyk, Megan
   Tang, Steven S.
   Nguan, Chris
TI Scrotal lymphangiomatosis: a case report
SO CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
LA English
DT Article
ID LYMPHATIC MALFORMATION; SKIN-GRAFTS; RECONSTRUCTION
AB Lymphangiomas are benign tumours of the lymphatic system, and there are several reported cases of scrotal lymphangioma in the literature to date. We report a rare case of multilocular cutaneous lymphangiomatosis treated with surgical excision (total scrotectomy and reconstruction using split-thickness skin grafts with vacuum-assisted closure dressing).
C1 [Wong, Rachel; Melnyk, Megan; Tang, Steven S.; Nguan, Chris] Univ British Columbia, Dept Urol Sci, Vancouver, BC V5Z 1M9, Canada.
C3 University of British Columbia
RP Nguan, C (通讯作者)，Univ British Columbia, Dept Urol Sci, Gordon & Leslie Diamond Hlth Care Ctr, Level 6,2775 Laurel St, Vancouver, BC V5Z 1M9, Canada.
EM chris.nguan@ubcurology.com
RI Nguan, Christopher/V-1541-2017
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NR 15
TC 1
Z9 2
U1 0
U2 2
PU CANADIAN UROLOGICAL ASSOCIATION
PI DORVAL
PA 185 DORVAL AVENUE, STE 401, DORVAL, QC H9S 5J9, CANADA
SN 1911-6470
EI 1920-1214
J9 CUAJ-CAN UROL ASSOC
JI CUAJ-Can. Urol. Assoc. J.
PD FEB
PY 2012
VL 6
IS 1
BP E11
EP E14
DI 10.5489/cuaj.10139
PG 4
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA V39KB
UT WOS:000209408800004
PM 22396376
DA 2026-07-24
ER
PT J
AU Plaudis, H
   Rudzats, A
   Melberga, L
   Kazaka, I
   Suba, O
   Pupelis, G
AF Plaudis, Haralds
   Rudzats, Agris
   Melberga, Liene
   Kazaka, Ita
   Suba, Olegs
   Pupelis, Guntars
TI Abdominal negative-pressure therapy: a new method in countering
   abdominal compartment and peritonitis - prospective study and critical
   review of literature
SO ANNALS OF INTENSIVE CARE
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; INTRAABDOMINAL HYPERTENSION; WOUND CLOSURE;
   INTERNATIONAL-CONFERENCE; OPEN ABDOMEN; EXPERIENCE; MANAGEMENT; EXPERTS;
   TRAUMA; FLUID
AB Background: Application of abdominal negative-pressure therapy (NPT) is lifesaving when conservative measures fail to reduce sustained increase of the intra-abdominal pressure and it is impossible to achieve source control in a single operation due to severe peritonitis. The aim of this study is to share the initial experience with abdominal NPT in Latvia and provide a review of the relevant literature.
   Methods: In total, 22 patients were included. All patients were treated with KCI (R) ABThera (TM) NPT systems. Acute Physiology and Chronic Health Evaluation II (APACHE II) score on admission, daily sequential organ failure assessment score and Mannheim peritonitis index (MPI) were calculated for severity definition. The frequency of NPT system changes, daily amount of aspirated fluid effluent and the time of abdominal closure were assessed. The overall hospital and ICU stay, as well as the outcomes and the complication rate, were analysed.
   Results: A complicated intra-abdominal infection was treated in 18 patients. Abdominal compartment syndrome due to severe acute pancreatitis (SAP), secondary ileus and damage control in polytrauma were indications for NPT in four patients. The median age of the patients was 59 years (range, 28 to 81), median APACHE II score was 15 points (range, 9 to 32) and median MPI was 28 points (range, 21 to 40), indicating a prognostic mortality risk of 60%. Sepsis developed in all patients, and in 20 of them, it was severe. NPT systems were changed on a median of every 4 days, and abdominal closure was feasible on the seventh postoperative day without needing a repeated laparotomy. Two NPT systems were removed due to bleeding from the retroperitoneal space in patients with SAP. Intestinal fistulae developed in three patients that were successfully treated conservatively. Incisional hernia occurred in three patients. The overall ICU and hospital stay were 14 (range, 5 to 56) and 25 days (range, 10 to 87), respectively. Only one patient died, contributing to the overall mortality of 4.5%.
   Conclusions: Application of abdominal NPT could be a very promising technique for the control of sustained intra-abdominal hypertension and management of severe sepsis due to purulent peritonitis. Further trials are justified for a detailed evaluation of abdominal NPT indications.
C1 [Plaudis, Haralds; Rudzats, Agris; Melberga, Liene; Kazaka, Ita; Pupelis, Guntars] Riga East Clin Univ Hosp Gailezers, Dept Gen & Emergency Surg, LV-1038 Riga, Latvia.
   [Suba, Olegs] Riga East Clin Univ Hosp Gailezers, Intens Care Clin, LV-1038 Riga, Latvia.
C3 Riga East University Hospital; Riga East University Hospital
RP Plaudis, H (通讯作者)，Riga East Clin Univ Hosp Gailezers, Dept Gen & Emergency Surg, 2 Hipokrata St, LV-1038 Riga, Latvia.
EM hplaudis@gmail.com
RI /AAS-7471-2020
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NR 36
TC 17
Z9 20
U1 0
U2 6
PU SPRINGEROPEN
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2110-5820
J9 ANN INTENSIVE CARE
JI Ann. Intensive Care
PY 2012
VL 2
SU 1
AR S23
DI 10.1186/2110-5820-2-S1-S23
PG 6
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA V41UF
UT WOS:000209570400023
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Emohare, O
   Kowal-Vern, A
   Wiley, D
   Latenser, BA
AF Emohare, O
   Kowal-Vern, A
   Wiley, D
   Latenser, BA
TI Vacuum-assisted closure use in calciphylaxis
SO JOURNAL OF BURN CARE & REHABILITATION
LA English
DT Article
ID PARATHYROIDECTOMY; SURVIVAL; SYSTEM
AB Calciphylaxis-induced chronic wounds are difficult to heal. The value of vacuum-assisted closure (VAC) was assessed in two patients with calciphylaxis. Two middle-aged females with type 2 diabetes were transferred to the burn unit with a clinical diagnosis of necrotizing fasciitis, although the pathologic diagnosis was calciphylaxis. With extensive debridement, antibiotics, and meticulous wound care, one patient had progressive necrosis of her skin from 18 to 48% TBSA, whereas the other progressed from 5 to 10% TBSA only. The patient with the smaller chronic wound healed well and left the hospital at 72 days after admission. Although there was some success with the use of VAC, the patient with the extensive progressive wounds developed a fungal wound infection that did not respond to treatment; she died 78 days after initiation of burn center treatment. Some disadvantages to the usefulness would be extensive contiguous wounds and the lack of an intact skin surface. The VAC system was of value in healing wounds resulting from calciphylaxis.
C1 Cook Cty Hosp, Sumner L Koch Burn Ctr, Dept Trauma, Chicago, IL 60612 USA.
   Univ London Imperial Coll Sci & Technol, Fac Med, London, England.
C3 John H Stroger Junior Hospital Cook County; Imperial College London
RP Latenser, BA (通讯作者)，Cook Cty Hosp, Sumner L Koch Burn Ctr, Dept Trauma, 1901 W Harrison St, Chicago, IL 60612 USA.
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NR 14
TC 8
Z9 16
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0273-8481
J9 J BURN CARE REHABIL
JI J. Burn Care Rehabil.
PD MAR-APR
PY 2004
VL 25
IS 2
BP 161
EP 164
DI 10.1097/01.BCR.0000111764.67904.CD
PG 4
WC Emergency Medicine; Rehabilitation; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Rehabilitation; Surgery
GA 800QT
UT WOS:000220043500002
PM 15091142
DA 2026-07-24
ER
PT J
AU Weed, T
   Ratliff, C
   Drake, DB
AF Weed, T
   Ratliff, C
   Drake, DB
TI Quantifying bacterial bioburden during negative pressure wound therapy -
   Does the wound VAC enhance bacterial clearance?
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   Southeastern-Society-of-Plastic-and-Reconstructive-Surgeons
CY JUN   02, 2003
CL Palm Beach, FL
SP SE Soc Plast & Reconstruct Surg
ID ASSISTED CLOSURE; INFECTIONS; SKIN
AB The bacterial colonization of a wound is a recognized detrimental factor in the multifactorial process of wound healing. The harmful effects on wound healing are recognized to correspond to a level of > 10(5) colonies of bacteria per gram of tissue. Negative pressure wound therapy has become an accepted treatment modality for acute and chronic wounds with accelerated healing rates observed. It has been previously reported that this therapy enhances bacterial clearance, which may account for the wound healing effects noted. We retrospectively reviewed 25 patients' charts undergoing Wound VAC (Vacuum Assisted Closure Device; KCI International, San Antonio, TX) therapy with serial quantitative cultures and found that there is not a consistent effect of bacterial clearance with the Wound VAC. Furthermore, bacterial colonization increased significantly with Wound VAC therapy and remained in a range of 10(4)-10(6). Despite this finding, the beneficial effects of this treatment modality on wound healing were noted in most cases.
C1 Univ Virginia Hlth Syst, Dept Plast Surg, Charlottesville, VA 22908 USA.
C3 University of Virginia; University of Virginia (UVA) Health System
RP Drake, DB (通讯作者)，Univ Virginia Hlth Syst, Dept Plast Surg, POB 800376, Charlottesville, VA 22908 USA.
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NR 12
TC 231
Z9 287
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAR
PY 2004
VL 52
IS 3
BP 276
EP 279
DI 10.1097/01.sap.0000111861.75927.4d
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 802HN
UT WOS:000220154700013
PM 15156981
DA 2026-07-24
ER
PT J
AU Molnar, JA
   DeFranzo, AJ
   Hadaegh, A
   Morykwas, MJ
   Shen, P
   Argenta, LC
AF Molnar, JA
   DeFranzo, AJ
   Hadaegh, A
   Morykwas, MJ
   Shen, P
   Argenta, LC
TI Acceleration of integra incorporation in complex tissue defects with
   subatmospheric pressure
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ARTIFICIAL SKIN; RECONSTRUCTIVE SURGERY;
   CLINICAL-EXPERIENCE; WOUND CONTROL; BURNS; DESIGN; DERMIS; MODEL
AB In an effort to accelerate vascularization and simplify the care of Integra (Ethicon, Inc., Somerville, NJ.), topical subatmospheric pressure was used for eight patients (age range, 2 to 60 years) with complex wounds. Bone was exposed in 62.5 percent of cases, joint in 50 percent, tendon in 37.5 percent, and bowel in 25 percent. The estimated Integra take rate was 96 percent. Split-thickness skin grafting was performed at 4 to 11 days (mean, 7.25 days), with a 93 percent take rate. No adverse side effects were observed with this technique. Application of subatmospheric pressure improved the take rate and time to vascularization of Integra, compared with previous published results, even with complicated wounds. This technique may be a practical alternative to flap closure.
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27109 USA.
   Wake Forest Univ, Sch Med, Dept Gen Surg, Winston Salem, NC 27109 USA.
C3 Wake Forest University; Wake Forest University
RP Molnar, JA (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27109 USA.
EM jmolnar@wfubmc.edu
RI Molnar, Joseph/AEK-5540-2022
OI Morykwas, Michael/0009-0001-5547-5172
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NR 22
TC 158
Z9 190
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR 15
PY 2004
VL 113
IS 5
BP 1339
EP 1346
DI 10.1097/01.PRS.0000112746.67050.68
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 809DZ
UT WOS:000220618700004
PM 15060345
DA 2026-07-24
ER
PT J
AU Wackenfors, A
   Sjögren, J
   Algotsson, L
   Gustafsson, R
   Ingemansson, R
   Malmsjö, M
AF Wackenfors, A
   Sjögren, J
   Algotsson, L
   Gustafsson, R
   Ingemansson, R
   Malmsjö, M
TI The effect of vacuum-assisted closure therapy on the pig femoral artery
   vasomotor responses
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID CONGESTIVE-HEART-FAILURE; ENDOTHELIN-B-RECEPTOR; RAT MESENTERIC-ARTERY;
   CORONARY-ARTERIES; NITRIC-OXIDE; ANGIOTENSIN-II; BLOOD-VESSELS;
   ORGAN-CULTURE; WOUND CONTROL; UP-REGULATION
AB Vacuum-assisted closure (VAC) is frequently used to treat wound infections. The aim of the present study was to evaluate the effect of VAC therapy on blood vessels. Vasodilatation and vasoconstriction were studied in isolated ring segments of the pig femoral artery after continuous VAC therapy of an inguinal wound for 12 hours. Vasoconstriction induced by endothelin-1 (ET-1), which is mainly an endothelin type A receptor agonist (Emax = 181 +/- 2% of potassium), and the endothelin type B receptor agonist, sarafotoxin 6c (Emax = 30 +/- 1%), were significantly increased after VAC therapy (ET-1; 325 +/- 3% and sarafotoxin 6c; 69 +/- 1%). The norepinephrine-, phenylephrine-, and angiotensin II-induced vasoconstrictions were not affected by VAC therapy. Acetylcholine induced an endothelium-dependent dilatation that was enhanced after VAC therapy (Rmax = 38 +/- 1% of norepinephrine-preconstriction after sham and 47 +/- 1% after VAC therapy, p < 0.05). The dilatory response was mediated by nitric oxide (Rmax = 39 +/- 1%), prostaglandins (5 +/- 1%) and endothelium-derived hyperpolarizing factor (16 +/- 1%), which were all significantly increased after VAC therapy. In conclusion, VAC therapy for 12 hours enhances an endothelin type A and type B receptor-mediated vasoconstriction. This may be compensated for by a more efficacious endothelium-dependent vasodilatation. No spontaneous bleeding, perforation, dissection, or other macroscopic change could be observed in the arteries exposed to VAC therapy.
C1 Univ Lund Hosp, Div Expt Vasc Res, Dept Internal Med, SE-22184 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Surg, SE-22184 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Anesthesia, SE-22184 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Wackenfors, A (通讯作者)，Univ Lund Hosp, Div Expt Vasc Res, Dept Internal Med, BMC A13, SE-22184 Lund, Sweden.
EM angelica.wackenfors@med.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
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TC 24
Z9 32
U1 0
U2 1
PU BLACKWELL PUBLISHING INC
PI MALDEN
PA 350 MAIN ST, MALDEN, MA 02148 USA
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JI Wound Repair Regen.
PD MAR-APR
PY 2004
VL 12
IS 2
BP 244
EP 251
DI 10.1111/j.1067-1927.2004.012117.x
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 812QA
UT WOS:000220852800015
PM 15086776
DA 2026-07-24
ER
PT J
AU Molnar, JA
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TI The science behind negative pressure wound therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
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RP Molnar, JA (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27109 USA.
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PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2004
SU S
BP 2
EP 5
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 817VB
UT WOS:000221203900002
PM 15317235
DA 2026-07-24
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C1 Loma Linda Univ, Med Ctr, Div Plast & Reconstruct Surg, Loma Linda, CA 92350 USA.
C3 Loma Linda University
RP Gupta, S (通讯作者)，Loma Linda Univ, Med Ctr, Div Plast & Reconstruct Surg, Loma Linda, CA 92350 USA.
EM sgupta@ahs.llumc.edu
RI Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922
NR 0
TC 0
Z9 1
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2004
SU S
BP 6
EP 8
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 817VB
UT WOS:000221203900003
PM 15317236
DA 2026-07-24
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NR 21
TC 11
Z9 16
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2004
SU S
BP 9
EP 12
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 817VB
UT WOS:000221203900004
PM 15317237
DA 2026-07-24
ER
PT J
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AF Mendez-Eastman, S
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SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
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C1 Univ Nebraska, Med Ctr, Omaha, NE 68182 USA.
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PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
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PY 2004
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BP 13
EP 16
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 817VB
UT WOS:000221203900005
PM 15317238
DA 2026-07-24
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C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27109 USA.
   Wake Forest Univ, Sch Med, Burn Unit, Winston Salem, NC 27109 USA.
C3 Wake Forest University; Wake Forest University
RP Molnar, JA (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27109 USA.
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TC 14
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PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2004
SU S
BP 17
EP 19
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 817VB
UT WOS:000221203900006
PM 15317239
DA 2026-07-24
ER
PT J
AU Webb, LX
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AF Webb, LX
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TI Negative pressure wound therapy in the management of orthopedic wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE
C1 Wake Forest Univ, Sch Med, Dept Orthoped Surg, Winston Salem, NC 27109 USA.
C3 Wake Forest University
RP Webb, LX (通讯作者)，Wake Forest Univ, Sch Med, Dept Orthoped Surg, Winston Salem, NC 27109 USA.
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NR 7
TC 5
Z9 10
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2004
SU S
BP 26
EP 27
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 817VB
UT WOS:000221203900009
PM 15317242
DA 2026-07-24
ER
PT J
AU Fifes, CE
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LA English
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NR 5
TC 4
Z9 10
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2004
SU S
BP 28
EP 31
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 817VB
UT WOS:000221203900010
PM 15317243
DA 2026-07-24
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SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
C1 Loma Linda Univ, Med Ctr, Div Plast, Loma Linda, CA 92350 USA.
   Loma Linda Univ, Med Ctr, Dept Reconstruct Surg, Loma Linda, CA 92350 USA.
C3 Loma Linda University; Loma Linda University
RP Gupta, S (通讯作者)，Loma Linda Univ, Med Ctr, Div Plast, Loma Linda, CA 92350 USA.
EM sgupta@ahs.llumc.edu
RI ; Gupta, Subhas/C-5458-2018; Gabriel, Allen/AFK-3548-2022
OI Shores, Jaimie/0000-0002-4272-1389; Gupta, Subhas/0000-0001-5091-3922; 
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NR 7
TC 8
Z9 13
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2004
SU S
BP 32
EP 34
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 817VB
UT WOS:000221203900011
PM 15317244
DA 2026-07-24
ER
PT J
AU Langley-Hawthorne, C
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C1 Eth Strategies Ltd, Oakland, CA USA.
RP Langley-Hawthorne, C (通讯作者)，Eth Strategies Ltd, Oakland, CA USA.
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NR 8
TC 3
Z9 8
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2004
SU S
BP 35
EP C3
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 817VB
UT WOS:000221203900012
PM 15317245
DA 2026-07-24
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PT J
AU [Anonymous]
AF [Anonymous]
TI Guidelines regarding negative wound therapy (NPWT) in the diabetic foot
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; LOWER-EXTREMITY;
   SUBATMOSPHERIC PRESSURE; TISSUE EXPANSION; PREVALENCE; AMPUTATION;
   MULTICENTER; ULCERATION; STANDARDS
AB The purpose of these guidelines is to the summarize consensus of a multidisciplinary expert advisory panel convened to determine appropiriate use of negative pressure wound therapy (NPWT), also known as Vacuum-Assisted Closure(R) or V.A.C.(R) Therapy, in the treatment of diabetic foot wounds. The Tucson Expert Consensus Conference (TECC) on V.A.C. Therapy was convened in an effort to guide the direction for future research either to confirm or refute current consensus while providing practical guidance to the clinician currently treating diabetic foot wounds. The consensus committee discussed and commented on the following ten key questions regarding NPWT 1) How long should NPWT be used in the treatment of a diabetic foot wound? 2) Should NPWT be applied to a wound that has not been debrided? 3) How should the patient using NPWT be evaluated on an outpatient basis? 4) When should NPWT be applied following lower-extremity bypass? 5) When should NPWT be applied after incision and drainage of infection? 6) How should NPWT be used in patients with osteomyelitis? 7) How should nonadherence (i.e., noncompliance) be defined in the patient on NPWT? When should NPWT be discontinued in this population? 8) How should NPWT be used in combination with other modalities? 9) Should small, superficial, noninfected wounds be considered for NPWT? 10) How should we define success in future studies of NPWT?.
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NR 64
TC 36
Z9 49
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2004
SU B
BP 3S
EP 27S
PG 25
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 819MZ
UT WOS:000221320300001
PM 15311482
DA 2026-07-24
ER
PT J
AU Lynch, JB
   Laing, AJ
   Regan, PJ
AF Lynch, JB
   Laing, AJ
   Regan, PJ
TI Vacuum-assisted closure therapy: A new treatment option for recurrent
   pilonidal sinus disease. Report of three cases
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE pilonidal sinus disease; vacuum-assisted closure
ID FLAP; EXPERIENCE; EXCISION
AB No single treatment option available for symptomatic pilonidal disease is entirely satisfactory. In our department, we have treated successfully three cases of pilonidal disease with vacuum-assisted closure therapy. We describe our initial experience with this technique. In two cases, the pilonidal sinus was primarily excised, a split skin graft applied to cover the defect, and the vacuum-assisted closure pump applied over the skin graft for a period of four days on a continuous negative pressure of 50 mmHg. The third case was treated and completely healed with vacuum-assisted closure therapy alone. To our knowledge, this is the first report in the literature describing the use of vacuum-assisted closure therapy for this condition. We propose this therapy as an alternative adjunctive treatment for pilonidal disease.
C1 Univ Coll Hosp Galway, Dept Plast Reconstruct & Hand Surg, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway
EM jennylynch@oceanfree.net
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NR 15
TC 29
Z9 39
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0012-3706
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD JUN
PY 2004
VL 47
IS 6
BP 929
EP 932
DI 10.1007/s10350-004-0522-2
PG 4
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 825RV
UT WOS:000221776900023
PM 15129309
DA 2026-07-24
ER
PT J
AU Wetzel-Roth, W
   Zöch, G
AF Wetzel-Roth, W
   Zöch, G
TI Consensus of the German and Austrian Societies for Wound Healing and
   Wound Management on vacuum closure and the VAC® treatment unit
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE Wound Management; vacuum closure; VAC((R)) treatment
AB Within the framework of the Three-Country Congress on V.A.C.(R) Treatment (Vacuum Assisted Closure Treatment) held on May 16/17, 2003 in Salzburg, a Consensus Conference involving members of the Committees of the German and Austrian Societies for Wound Management was convened. In view of the divergence of opinion on the effectiveness of the treatment among the cost carriers, it appeared appropriate for the two Societies for Wound Healing in Germany and Austria to arrive at a consensus on the importance of and the indications for the management of wounds with the vacuum closure method. Since the first clinical applications in the nineteen-forties, both the indication spectrum and the number of applications have increased continually. In addition to diverse vacuum closure systems, there is patented computer-controlled system technology available that is established V.A.C.(R) treatment. Although this is a hospital-based system, it can also be used on an outpatient basis by appropriately trained physicians and nursing staff and in instructed patients. For some indications, vacuum closure and V.A.C.(R) management is considered the treatment of choice, since no equivalent alternative methods are available. A con-benefit analysis shows that vacuum closure and V.A.C.(R) treatment is cost effective.
C1 DGFW, D-35392 Giessen, Germany.
RP Wetzel-Roth, W (通讯作者)，Hindenburgstr 1, D-86807 Buchloe, Germany.
EM dr.walter.wetzel-roth@onlinemed.de
NR 0
TC 11
Z9 18
U1 0
U2 1
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S7
EP S11
DI 10.1055/s-2004-822677
PG 5
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 826GF
UT WOS:000221816600004
PM 15168274
DA 2026-07-24
ER
PT J
AU Labler, L
   Keel, M
   Trentz, O
AF Labler, L
   Keel, M
   Trentz, O
TI New application of VAC® (Vacuum Assisted Closure) in the abdominal
   cavity in case of open abdomen therapy
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE open abdomen; infection; vacuum assisted closure; VAC((R))
ID DAMAGE-CONTROL LAPAROTOMY; MASSIVE VENTRAL HERNIAS; AORTIC-ANEURYSM
   REPAIR; COMPARTMENT SYNDROME; PACK TECHNIQUE; WOUND CONTROL; PRESSURE;
   MESH; EXPERIENCE; TRAUMA
AB Objective: The problem of the temporary vacuum assisted closure (V.A.C.(R)) of open abdomen situation is that the fluids, following the negative pressure, pass the abdominal cavity and in case of a local infection disseminate over the whole abdominal cavity.
   Methods: The usual open abdominal wound V.A.C.(R) technique was modified by using an auxiliary, independently operating V.A.C.(R) system positioned intra-abdominally and connected with a separate drainage tube introduced into the lateral abdominal wall. This arrangement prevents further spreading of a local intra-abdominal infection in case of a necrotising pancreatitis after traumatic pancreas rupture.
   Results: The drainage volumes were comparable from superficial and intra-abdominal V.A.C.(R) system. A total of 30 reoperations were necessary due to a leasion of the pancreas before a primary closure of the open abdominal wound could be applied after 72 days. No bowel fistulas or intra-abdominal abscess formations were observed. The follow-up have not shown any hernia of the abdominal wall up to the present.
   Conclusion: Additional intra-abdominally positioned V.A.C.(R) system with an own drainage system supports open abdomen therapy with the standard abdominal V.A.C.(R) system and prevents dissemination of intra-abdominal infection.
C1 Univ Zurich Hosp, Unfallchirurg Klin, Dept Chirurg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Labler, L (通讯作者)，Univ Zurich Hosp, Unfallchirurg Klin, Dept Chirurg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM ludwig.labler@chi.usz.ch
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NR 37
TC 17
Z9 23
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S14
EP S19
DI 10.1055/s-2004.822668
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600006
PM 15168276
DA 2026-07-24
ER
PT J
AU Rexer, M
   Ditterich, D
   Rupprecht, H
AF Rexer, M
   Ditterich, D
   Rupprecht, H
TI VAC®-therapy in abdominal surgery - Experiences, limits and
   indications
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE VAC((R))-therapy; abdominal surgery; indications
ID VACUUM-ASSISTED CLOSURE; PACK TECHNIQUE; MANAGEMENT; FISTULA
AB Compared to other surgical disciplines the significance of V.A.C.(R)-therapy is rarely noticed in abdominal surgery. This may be due to uncertainty in defining clear indications or lack of technical know-how.
   Methods: We report on five selected septic cases in abdominal surgery without clearly defined indications for V.A.C.(R)-therapy (ischiorectal abscess, perforation in Crohn's disease, pelvic abscess due to perforation caused by rectal carcinoma, abdominal compartment syndrome, anastomotic leak after rectal resection).
   Results: Regarding the individual aspects of indication, V.A.C.(R)-therapy could be used successfully in the demonstrated cases. Under the palliative aspect, V.A.C.(R)-therapy on a malignant wound bed allowed an early treatment with chemotherapy.
   Discussion: According to the literature dealing with V.A.C.(R)-therapy, enterocutaneous fistulas, exposed viscera, enteral surfaces as well as malignancy in the wound bed are considered to be contraindications for the method. Reffering to our observations, these diagnoses should not be strictly regarded as contraindications. Elaboration of clear guidelines that point out clearly defined indications for V.A.C.(R)-therapy should be the goal for the future.
C1 Klinikum Furth, Chirurg Klin 1, D-90766 Furth, Germany.
RP Rexer, M (通讯作者)，Klinikum Furth, Chirurg Klin 1, Jakob Henle Str 1, D-90766 Furth, Germany.
EM martin.rexer@tiscali.de
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Cro C, 2002, POSTGRAD MED J, V78, P364, DOI 10.1136/pmj.78.920.364
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   WEIDENHAGEN R, 2003, J WOUNDHEALING
NR 13
TC 11
Z9 11
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S27
EP S32
DI 10.1055/s-2004-822640
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600009
PM 15168279
DA 2026-07-24
ER
PT J
AU Kutschka, I
   Frauendorfer, P
   Harringer, W
AF Kutschka, I
   Frauendorfer, P
   Harringer, W
TI Vacuum assisted closure therapy improves early postoperative lung
   function in patients with large sternal wounds
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE vacuum therapy; sternal infection; lung function
AB Vacuum assisted closure of sternal wounds is a sound strategy for patients with severe poststernotomy mediastinitis and sternal bone necrosis. As a bridging therapy to reconstructive surgery it provides an adequate temporary stabilization of the thorax. It enhances lung function and reduces pulmonary complications.
C1 Klin Herz Thorax & Gefasschirurg, Stadt Klinikum Braunschweig, D-38126 Braunschweig, Germany.
RP Kutschka, I (通讯作者)，Klin Herz Thorax & Gefasschirurg, Stadt Klinikum Braunschweig, Salzdahlumerstr 90, D-38126 Braunschweig, Germany.
EM htg@klinikum-braunschweig.de
OI Harringer, Wolfgang/0000-0001-8899-4828; Kutschka,
   Ingo/0000-0002-7358-3513
NR 0
TC 14
Z9 20
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S33
EP S34
DI 10.1055/s-2004-822607
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600010
PM 15168280
DA 2026-07-24
ER
PT J
AU Fleck, T
   Moidl, R
   Giovanoli, P
   Wolner, E
   Grabenwoger, M
AF Fleck, T
   Moidl, R
   Giovanoli, P
   Wolner, E
   Grabenwoger, M
TI Early treatment of sternal wound infections with vacuum assisted closure
   therapy reduces involvement of the mediastinum and further diminishes
   the need of plastic reconstructive surgery
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
ID BRIDGE
C1 AKH Wien, Abt Herz Thoraxchirurg, A-1090 Vienna, Austria.
   AKH Wien, Abt Plast Chirurg, A-1090 Vienna, Austria.
C3 University Hospital Vienna; University Hospital Vienna
RP Fleck, T (通讯作者)，AKH Wien, Abt Herz Thoraxchirurg, Leitstelle 20A,Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM t9204604@hotmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Fleck TM, 2004, ANN PLAS SURG, V52, P310, DOI 10.1097/01.sap.0000105524.75597.e0
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Francel TJ, 2001, ANN THORAC SURG, V72, P1411, DOI 10.1016/S0003-4975(00)02008-7
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Hollenbeak CS, 2000, CHEST, V118, P397, DOI 10.1378/chest.118.2.397
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
NR 9
TC 6
Z9 7
U1 0
U2 1
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S35
EP S37
DI 10.1055/s-2004-822615
PG 3
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 826GF
UT WOS:000221816600011
PM 15168281
DA 2026-07-24
ER
PT J
AU Halama, D
   Hemprich, A
   Frerich, B
AF Halama, D
   Hemprich, A
   Frerich, B
TI Intraoral application of vacuum-assisted closure in the treatment of an
   extended mandibular keratocyst
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE keratocyst; Vacuum-Assisted Closure; woundhealing
ID LARGE ODONTOGENIC KERATOCYSTS; MANAGEMENT
AB In extended cysts of the jaw bone particular demands are made in terms of wound closure, especially if an intraoral surgical approach is chosen. A tight closure is even more important if the bony defect has been filled with an alloplastic material or autologous cancellous bone.
   In our case a keratocyst of the left mandibular angle and ascending ramus was treated.
   After enucleation of the cyst and grafting with autologous cancellous bone the graft was lost following a wound breakdown. Subsequently a system was developed to apply intraoral V.A.C.(R)-therapy. This led to a safe separation of the cystic defect and the oral cavity and a conditioning of the wound ground. A grafting with an alloplastic material was carried out successfully. with this method the length of treatment could be reduced by several months compared to a conventional therapy with an obturator.
C1 Univ Klinikum Leipzig, Klin & Poliklin Mund Kiefer & Plast Gesicht, D-04103 Leipzig, Germany.
C3 Leipzig University
RP Halama, D (通讯作者)，Univ Klinikum Leipzig, Klin & Poliklin Mund Kiefer & Plast Gesicht, Nurnberger Str 57, D-04103 Leipzig, Germany.
EM dirk.halama@medizin.uni-leipzig.de
RI ; Hemprich, Alexander/JXL-9631-2024
OI Frerich, Bernhard/0000-0001-6707-2429; 
CR [Anonymous], 1956, TANDL GEBLADET, V60, P963
   Bauer P, 1998, Handchir Mikrochir Plast Chir, V30, P20
   CROWLEY TE, 1992, J ORAL MAXIL SURG, V50, P22, DOI 10.1016/0278-2391(92)90187-5
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   SCHWENZER N, 2000, ZAHN MUND KIEFER HEI, V3, P96
   WILLIAMS TP, 1994, J ORAL MAXIL SURG, V52, P964, DOI 10.1016/S0278-2391(10)80081-3
NR 11
TC 4
Z9 10
U1 0
U2 0
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S53
EP S56
DI 10.1055/s-2004-822669
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 826GF
UT WOS:000221816600017
PM 15168287
DA 2026-07-24
ER
PT J
AU Ferbert, T
   Kuhfuss, I
   Ziegler, UE
AF Ferbert, T
   Kuhfuss, I
   Ziegler, UE
TI Treatment of soft tissue defects on hand and forearm with vacuum
   assisted closure
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE vacuum assisted closure; installation; chronic wound
AB Vacuum assisted closure techniques cover the whole spectrum (VAC) of treatments in soft tissue defects, not only on the surface of the body. The combination of VAC and sharp debridement keep the principal of wound bed preparation. More and more clinical experience increases the options of this method (control of infection), reduction of oedema (pre- and postoperatively) and take rates of grafts. The vacuum-installation-technique offers new treatments in acute and chronic wounds.
C1 Chirurg Univ Klin Wurzburg, Plast Chirurg & Handchirurg, D-97080 Wurzburg, Germany.
C3 University of Wurzburg
RP Ziegler, UE (通讯作者)，Chirurg Univ Klin Wurzburg, Plast Chirurg & Handchirurg, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany.
EM ulrich.ziegler@mail.uni-wuerzburg.de
NR 0
TC 1
Z9 1
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S57
EP S58
DI 10.1055/s-2004-822667
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600018
PM 15168288
DA 2026-07-24
ER
PT J
AU Karl, T
   Modic, PK
   Voss, EU
AF Karl, T
   Modic, PK
   Voss, EU
TI Indications and results of VAC® therapy treatments in
   vascular surgery state of the art in the treatment of chronic wounds
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE VAC((R)) therapy; chronic wounds; varicose ulcer; diabetic gangrene;
   vascular graft infections
AB Almost 10% of the population are concerned in the course of her life by chronic wounds, mortality resulting from this amount to 2.5% [15, 25, 34]. The Vacuum assisted closure (V.A.C.(R)) therapy represents a modern procedure for the treatment of chronic wounds. Also in some first appearing offering no prospects cases hereby the Majoramputation can be prevented and the majority of chronic therapy-resistant wounds can be healed. Due to first experiences with the V.A.C.(R) therapy with the treatment of infected vascular grafts in the stage II and III after Szilagyi it also offers a success - promising option to concerne the extremity and the life of the patient and to receive but also the infected graft in situ.
C1 Stadt Kliniken Karlsruhe, Chirurg Klin, D-76133 Karlsruhe, Germany.
   Univ Freiburg, Akad Lehrkrankenhaus, D-7800 Freiburg, Germany.
C3 Municipal Hospital Karlsruhe; University of Freiburg
RP Karl, T (通讯作者)，Stadt Kliniken Karlsruhe, Chirurg Klin, Moltkestr 90, D-76133 Karlsruhe, Germany.
EM dr.t.karl@web.de
CR Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Banwell P E, 1999, J Wound Care, V8, P79
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   Fleischmann W, 1998, UNFALLCHIRURG, V101, P649, DOI 10.1007/s001130050318
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   HEPP W, 2001, GEFASSCHIRUGIE, P669
   KEHR HH, 1997, AKUTE CHRONISCHE WUN, P55
   KOHLER U, 1998, GEFASSCHIRURGIE, V3, P82
   Labler L, 2003, EUR SURG ACA S, V35, P10
   LILGENAU N, 2003, EUR SURG ACA S, V35, P28
   MOEHRLEN U, 2003, EUR SURG ACA S, V35, P17
   MOIDL R, 2003, EUR SURG ACA S, V35, P22
   Molnar JA, 2000, PLAST RECONSTR SURG, V105, P174, DOI 10.1097/00006534-200001000-00030
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   MORYKWAS MJ, 1998, ACTA CHIR, V150, P3
   PELKA RB, UNPUB EXPERTISE KOST
   Philippidis TP, 1999, COMPOS STRUCT, V45, P41, DOI 10.1016/S0263-8223(99)00012-4
   Rejzek A, 1998, ACTA CHIR AUST     S, V150, P12
   SCHERER LA, 2003, ARCH SURG-CHICAGO, V137, P930
   SCHLATTER M, 2003, EUR SURG ACA S, V35, P15
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   WALDENBERGER FR, 2003, EUR SURG ACA S, V35, P20
   Walgenbach KJ, 2000, Z FLUGWISS WELTRAUM, V13, P9
   *WEINB GROUP, 1999, TECHN ASS VAC HOM TR
   WINKLER M, 2004, Z FLUGWISS WELTRAUM, V9, P24
   ZIEGLER UE, 2003, EUR SURG ACA S, V35, P18
   2002, MILLIMAN STUDIE US E
NR 35
TC 9
Z9 17
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S74
EP S79
DI 10.1055/s-2004-822609
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600024
PM 15168294
DA 2026-07-24
ER
PT J
AU Ottomann, C
   Schönborn, A
   Hartmann, B
AF Ottomann, C
   Schönborn, A
   Hartmann, B
TI Management with VAC® in phlegmonous tissue defects of the
   abdominal wall after abdominoplasty
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE abdominoplasty; phlegmonous; VAC((R))-therapy; wound infection
ID VACUUM-ASSISTED CLOSURE; PRESSURE
AB Infected defects with tissue defects of the abdomial wall after abdomioplasty are a severe complication. Management of these progessive infections involves multiple step surgery. V.A.C.(R)-therapy could be an alternative to open wound treatment.
C1 Unfallkrankenhaus Berlin, Zentrum Schwerbrandverletzte Plast Chirurg, D-12683 Berlin, Germany.
RP Ottomann, C (通讯作者)，Unfallkrankenhaus Berlin, Zentrum Schwerbrandverletzte Plast Chirurg, Warener Str 7, D-12683 Berlin, Germany.
EM christian.ottomann@ukb.de
CR Cedidi C, 2002, EUR J MED RES, V7, P399
   DERTSCH T, 1994, 4 ANN M WOUND HEAL S
   Erdmann D, 2001, PLAST RECONSTR SURG, V108, P2066, DOI 10.1097/00006534-200112000-00036
   Hensel JM, 2001, ANN PLAS SURG, V46, P357, DOI 10.1097/00000637-200104000-00001
   KUCAN JO, 1981, J AM GERIATR SOC, V29, P232, DOI 10.1111/j.1532-5415.1981.tb01773.x
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Vastine VL, 1999, ANN PLAS SURG, V42, P34, DOI 10.1097/00000637-199901000-00006
   Walgenbach KJ, 2000, Z FLUGWISS WELTRAUM, V13, P9
NR 9
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S85
EP S88
DI 10.1055/s-2004-822662
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600027
PM 15168297
DA 2026-07-24
ER
PT J
AU Steiert, AE
   Partenheimer, A
   Schreiber, T
   Muehlberger, T
   Krettek, C
   Lahoda, LU
   Vogt, PM
AF Steiert, AE
   Partenheimer, A
   Schreiber, T
   Muehlberger, T
   Krettek, C
   Lahoda, LU
   Vogt, PM
TI The VAC® system (Vacuum Assisted Closure) as bridging between primary
   osteosynthesis in conjunction with functional reconstructed of soft
   tissue -: Open fractures type 2 and type 3
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
AB Open fractures are complex injuries affecting the integrity of bones and adjacent soft tissue. The therapeutic goals in dealing with open fractures should consist of primary osteosynthesis in conjunction with functional reconstruction of soft tissue. In a period over 2 years, 26 patients were treated with extensive trauma in an interdisciplinary approach. These patients suffered from open fractures type 2 and 3. All patients were treated by primary osteosynthesis, and temporary wound closure with V.A.C.(R)-system. Definitive wound closure was achieved by day 31 after injury.
   In contrast to a review of the pertinent literature we report the successful free tissue transfer in 21 patients during the critical period [2] between 72 hours and several months preceded by the use of V.A.C.(R)-system for the temporary coverage of open Wounds.
C1 Hannover Med Sch, Klinikum Hannover Oststadt, Klin Plast Hand & Wiederherstellungschirurg, Unfallchirurg Klin, D-30659 Hannover, Germany.
C3 Hannover Medical School
RP Steiert, AE (通讯作者)，Hannover Med Sch, Klinikum Hannover Oststadt, Klin Plast Hand & Wiederherstellungschirurg, Unfallchirurg Klin, Podbielskistr 380, D-30659 Hannover, Germany.
EM andreas.steiert.oststadt@klinikum-hannover.de
RI ; Vogt, Peter/AAL-1332-2020
OI Krettek, Christian/0000-0001-9807-0020; 
CR GODINA M, 1986, PLAST RECONSTR SURG, V78, P285, DOI 10.1097/00006534-198609000-00001
   Gopal S, 2000, J BONE JOINT SURG BR, V82B, P959, DOI 10.1302/0301-620X.82B7.10482
NR 2
TC 8
Z9 8
U1 0
U2 0
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S98
EP S100
DI 10.1055/s-2004-822658
PG 3
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 826GF
UT WOS:000221816600031
PM 15168301
DA 2026-07-24
ER
PT J
AU Mang, R
   Kovnerystyy, O
   Stege, H
AF Mang, R
   Kovnerystyy, O
   Stege, H
TI Vacuum therapy in a pre- and postsurgical ulcera crurum
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE vacuum assisted closure; leg ulcer; necrobiosis lipoidica; basal cell
   carcinoma; wound heating
AB Chronic wounds are often a diagnostic as well as a therapeutic problem. Three case reports depi important differential diagnoses. The importance and efficacy of vacuum assisted closure in a presurgical treatment as well as after mesh graft transplanation will be described.
C1 Univ Klinikum Dusseldorf, Hautklin, Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf Hospital
RP Stege, H (通讯作者)，Moorenstr 5, D-40225 Dusseldorf, Germany.
EM stege@med.uni-duesseldorf.de
CR Gallenkemper G, 1996, PHLEBOLOGIE, V25, P254
   Marinella MA, 2002, LANCET, V360, P1143, DOI 10.1016/S0140-6736(02)11200-1
   Pannier-Fischer F, 2003, HAUTARZT, V54, P1037, DOI 10.1007/s00105-003-0616-0
   Sibbald R Gary, 2003, Ostomy Wound Manage, V49, P52
NR 4
TC 1
Z9 1
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S101
EP S103
DI 10.1055/s-2004-822652
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600032
PM 15168302
DA 2026-07-24
ER
PT J
AU Kall, S
   Kilpadi, D
   Reimers, K
   Choi, CYU
   Jahn, S
   Vogt, PM
AF Kall, S
   Kilpadi, D
   Reimers, K
   Choi, CYU
   Jahn, S
   Vogt, PM
TI Influence of foam and tubing material of the Vacuum Assisted Closure
   device (VAC®) on the concentration of transforming growth factor beta 1
   in wound fluid
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE Vacuum Assisted Closure device; transforming growth factor beta 1;
   technical method
AB Background and purpose: The Vacuum Assisted Closure(R) device (V.A.C.(R)) is commonly used for the treatment of problematic wounds. Furthermore, wound fluid can be easily collected with this device for research purposes. However, there is inadequate information as to whether the measurement of biomoieties of importance to wound healing is affected by the exposure of wound fluid to V.A.C(R) components, namely Polyurethane-foarn and tubing. This study is an attempt to evaluate whether exposure of wound fluid to either V.A.C(R) -components affects concentrations of transforming growth factor beta I (TGF-b1) in wound fluid.
   Material and method: Wound fluid was gathered from five decubital ulcer patients using the foil-technique and was exposed to sterile peaces of the V.A.C.(R) Polyurethane-foam, tubing material or nothing for zero, one or five hours. Saline served as control. The concentration of TGF-b1 was measured using sandwich-ELISA. The resulting data were analyzed using two-way ANOVA, Newman-Keuls and Bonferroni t-Test.
   Results: The concentration of TGF-b1 decreased significant in all three groups during the five hours of the experiment (p < 0.05). There was no significant decrease in TGF-b1 concentration at any time point in-between the groups.
   Conclusion: From this study, we conclude that wound-fluid collected from the V.A.C(R).-device via the polyurethane-foam or tubing for purposes of analyzing concentrations of TGF-beta 1 should not be different from fluid collected using the foil technique.
C1 Hannover Med Sch, Klinikum Oststadt, Klin Plast Hand & Wiederherstellungschirurg Med, D-30659 Hannover, Germany.
   Kinet Concept Inc, San Antonio, TX USA.
C3 Hannover Medical School
RP Kall, S (通讯作者)，Hannover Med Sch, Klinikum Oststadt, Klin Plast Hand & Wiederherstellungschirurg Med, Podbeilskistr 380, D-30659 Hannover, Germany.
EM kall.susanne@mh-hannover.de
RI Vogt, Peter/AAL-1332-2020
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Demaria RG, 2003, J CARDIOVASC SURG, V44, P757
   HIDEYUKI Y, 2004, WOUND REPAIR REGEN, V12, pA10
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Penn Elaine, 2004, Br J Nurs, V13, P194
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
NR 7
TC 3
Z9 3
U1 0
U2 0
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S113
EP S115
DI 10.1055/s-2004-822659
PG 3
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 826GF
UT WOS:000221816600035
PM 15168305
DA 2026-07-24
ER
PT J
AU Kopp, J
   Bach, AD
   Kneser, U
   Polykandriotis, E
   Loos, B
   Krickhahn, M
   Jeschke, MG
   Horch, RE
AF Kopp, J
   Bach, AD
   Kneser, U
   Polykandriotis, E
   Loos, B
   Krickhahn, M
   Jeschke, MG
   Horch, RE
TI Indication and clinical results of buried skin grafting to treat
   problematic wounds
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE wound healing; skin grafting; vacuum therapy
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR RECONSTRUCTION; PERIANAL BURNS
AB In 1920 Braun described a technique of skin grafting particularly designed for areas where shearing forces, high pressure and extensive secretion cause repetitive loss of conventionally transplanted skin. During the last 10 years we successfully used this technique when impaired wound healing was encountered due to various reasons. Clinical examples of application and results are presented. By combining this technique with vacuum therapy, formation of granulation tissue can be accelerated, thereby resulting in successful trans plantation of problematic and therapy resistant wounds.
C1 Univ Klinikum Erlangen, Abt Plast & Handchirurg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Kopp, J (通讯作者)，Univ Klinikum Erlangen, Abt Plast & Handchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM juergen.kopp@chir.imed.uni-erlangen.de
RI Jeschke, Marc/D-3501-2019; Horch, Raymund/H-8128-2019
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NR 26
TC 2
Z9 3
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S129
EP S132
DI 10.1055/s-2004-822649
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600040
PM 15168310
DA 2026-07-24
ER
PT J
AU Querings, K
   Bonowitz, A
   Dill-Müller, D
AF Querings, K
   Bonowitz, A
   Dill-Müller, D
TI Revitalization of a gluteal abscesses with VAC® therapy
   (vacuum assisted closure)
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE gluteal abszess; intramuscular injection; vacuum-assisted closure
AB Abscess formation is a frequent complication following gluteal injection. Septic abscesses as well as aseptic necrosis of muscle or subcutaneous adipose tissue require surgical management. We present a case of subcutaneous necrosis following gluteal injection in which vacuum-assisted closure (V.A.C.(R) therapy) has been effectively applied in the phase of secondary wound healing following surgical drainage. V.A.C.(R) therapy offers ambulatory management with optimal hygiene and patient's comfort.
C1 Univ Saarlandes Kliniken, Hautklin & Poliklin, D-66421 Homburg, Germany.
C3 Universitatsklinikum des Saarlandes
RP Querings, K (通讯作者)，Univ Saarlandes Kliniken, Hautklin & Poliklin, D-66421 Homburg, Germany.
EM K.Querings@gmx.de
CR Abdelwahab IF, 1998, SKELETAL RADIOL, V27, P36, DOI 10.1007/s002560050333
   AHMED ME, 1989, J TROP MED HYG, V92, P317
   Bosscha K, 2002, Ned Tijdschr Geneeskd, V146, P649
   ZUBER M, 1987, SCHWEIZ MED WSCHR, V117, P328
NR 4
TC 0
Z9 0
U1 0
U2 0
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S138
EP S140
DI 10.1055/s-2004-822661
PG 3
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 826GF
UT WOS:000221816600043
PM 15168313
DA 2026-07-24
ER
PT J
AU Schintler, MV
   Prandl, EC
   Wittguber, G
   Zink, B
   Spendal, S
   Hellbom, B
   Scharnagl, E
AF Schintler, MV
   Prandl, EC
   Wittguber, G
   Zink, B
   Spendal, S
   Hellbom, B
   Scharnagl, E
TI The impact of the VAC-treatment for locally advanced malignancy of the
   scalp
SO ZENTRALBLATT FUR CHIRURGIE
LA English
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE cutaneous malignancy; scalp reconstruction; VAC((R)) -vacuum; assisted
   closure; geriatric patient; polymorbidity
ID DENUDED CRANIAL BONE; SOFT-TISSUE DEFECTS; ASSISTED CLOSURE; EXPOSED
   BONE; WOUND CONTROL; SKIN-GRAFTS; MANAGEMENT; SURGERY; REPAIR;
   ANESTHESIA
AB Locally advanced cutaneous malignancy of the scalp is a desease that requires an aggressive approach to resection and reconstruction. In cases where the pericranium is intact a split-thickness skin graft is a simple treatment, since direct closure often fails because due to the lack of elasticity of the scalp [11, 36]. If there is a loss of periosteum or a skull defect local or free flaps [27, 29, 44] are necessary for sufficient coverage. Increasing geriatric and polymorbid patients with impaired wound healing [4] require surgical treatment, considering pros and cons for general anaesthesia [7 - 9,13, 16, 45]. A simple method of both, combining radicality of tumorresection with outer table bone and skin grafting as a two stage procedure, while minimizing perioperative risk using local anaesthesia and analgo-sedation, using the vacuum assisted closure device, is presented.
C1 Med Univ Graz, Klin Abt Plast Chirurg, A-8036 Graz, Austria.
C3 Medical University of Graz
RP Schintler, MV (通讯作者)，Auenbruggerpl 29, A-8036 Graz, Austria.
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NR 50
TC 6
Z9 11
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S141
EP S146
DI 10.1055/s-2004-822690
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600044
PM 15168314
DA 2026-07-24
ER
PT J
AU Marathe, US
   Sniezek, JC
AF Marathe, US
   Sniezek, JC
TI Use of the vacuum-assisted closure device in enhancing closure of a
   massive skull defect
SO LARYNGOSCOPE
LA English
DT Article
DE eccrine carcinoma; skull defect; negative-pressure dressing;
   vacuum-assisted closure
ID WOUND CONTROL; MANAGEMENT; SYSTEM
AB Objectives/Hypothesis: The objective was to describe a novel technique for reconstructing the cranial vertex without the use of free tissue transfer. Study Design: Case report, literature review, and discussion. Methods: A 50-year-old woman presented from a remote Pacific Island community with a 12 x 14-cm, necrotic, grossly contaminated eccrine gland carcinoma of the cranial vertex that extended through the calvarium but did not invade the dura. Following tumor extirpation, the resulting bony defect was 10 x 12 cm in size, with a concomitant scalp defect of 14 x 16 em. Free tissue transfer was impossible because of severe intimal peripheral vascular disease, posing a challenging reconstructive dilemma. After tumor resection, the bony edges were covered with local scalp flaps and the vacuum-assisted closure device was placed over the wound at a constant setting of -50 mm Hg. The vacuum-assisted closure device was changed three times per week for 3 weeks. Results: A thick, 1-cm bed of granulation tissue developed over the dura, allowing temporary coverage by a split-thickness skin graft, and the scalp defect decreased in size by approximately 25%. The patient did not develop meningitis, headache, or localized infection as a result of placement of the vacuum-assisted closure device and tolerated the vacuum-assisted closure well. After a requisite period of healing, tissue expanders and calvarial reconstruction will be performed. Conclusion: Use of the vacuum-assisted closure device is a safe, reliable adjunct in the closure of large cranial defects with exposed dura and offers a novel reconstructive option for complex defects of the head and neck.
C1 Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA.
C3 United States Department of Defense; United States Army; Tripler Army
   Medical Center
RP Sniezek, JC (通讯作者)，Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta PA, 2002, OBSTET GYNECOL, V99, P497, DOI 10.1016/S0029-7844(01)01752-5
   Cro C, 2002, POSTGRAD MED J, V78, P364, DOI 10.1136/pmj.78.920.364
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Erdmann D, 2001, PLAST RECONSTR SURG, V108, P2066, DOI 10.1097/00006534-200112000-00036
   Harlan JW, 2002, PLAST RECONSTR SURG, V109, P710, DOI 10.1097/00006534-200202000-00045
   Hoffmann JF, 2001, OTOLARYNG CLIN N AM, V34, P571, DOI 10.1016/S0030-6665(05)70006-2
   Hopf H W, 2001, Foot Ankle Clin, V6, P661, DOI 10.1016/S1083-7515(02)00008-6
   Josty IC, 2001, BRIT J PLAST SURG, V54, P363, DOI 10.1054/bjps.2000.3565
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
NR 11
TC 25
Z9 33
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0023-852X
J9 LARYNGOSCOPE
JI Laryngoscope
PD JUN
PY 2004
VL 114
IS 6
BP 961
EP 964
DI 10.1097/00005537-200406000-00001
PG 4
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA 828RZ
UT WOS:000221991900001
PM 15179195
DA 2026-07-24
ER
PT J
AU Stone, P
   Prigozen, J
   Hofeldt, M
   Hass, S
   DeLuca, J
   Flaherty, S
AF Stone, P
   Prigozen, J
   Hofeldt, M
   Hass, S
   DeLuca, J
   Flaherty, S
TI Bolster versus negative pressure wound therapy for securing
   split-thickness skin grafts in trauma patients
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Purpose: The purpose of this retrospective chart review was to compare the effectiveness of negative pressure wound therapy (NPWT) (Vacuum-Assisted Therapy(R), V.A.C.(R), Kinetic Concepts, Inc., San Antonio, Texas) to traditional cotton bolster dressings in split-thickness skin graft (STSG) survival in trauma patients. Methods: The authors conducted a retrospective chart review of 40. patients admitted to a level I trauma center over a two-year period and treated with split-thickness skin grafting, with in-hospital graft survival as the main endpoint. Results: Forty patients underwent STSG placement over 46 wounds. Indications included soft tissue loss (graft n = 34) and fasciotomy site (n = 12). The grafts were secured using either NPWT (n = 21) or a traditional cotton bolster (n = 25). Zero grafts failed in the NPWT group, while one graft failure occurred in the bolster group on a sizeable soft tissue loss injury to the torso/extremity (300cm(2) graft). There were no significant differences in graft failure, mean graft size, total length of patient hospital stay; or length of time the dressings were left in place between the NPWT and bolster groups. Treatment costs were considerably larger in the NPWT group. The average cost per patient in the NPWT and cotton bolster groups were approximately $1,000 and $18.50, respectively. Conclusion: The in-hospital results achieved with NPWT compare well to the traditional cotton bolsters, with NPWT being a viable option for securing STSG and ensuring graft survival. However, the routine use of NPWT may not be cost effective. A prospective, randomized trial examining grafts with higher associated failure rates using these two modalities would help answer questions about NPWT's use in this patient population.
C1 W Virginia Univ, Sch Med, Charleston, WV USA.
C3 West Virginia University
RP Flaherty, S (通讯作者)，Charleston Area Med Ctr, Hlth Educ & Res Inst, 3211 MacCorkle Ave SE, Charleston, WV 25304 USA.
EM sarah.flaherty@camc.org
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Levit K, 2004, HEALTH AFFAIR, V23, P147, DOI 10.1377/hlthaff.23.1.147
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Rudolph R., 1990, PLASTIC SURG, VI, P221
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
NR 6
TC 19
Z9 24
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2004
VL 16
IS 7
BP 219
EP 223
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 840LV
UT WOS:000222861000001
DA 2026-07-24
ER
PT J
AU Oczenski, W
   Waldenberger, F
   Nehrer, G
   Kneifel, W
   Swoboda, H
   Schwarz, S
   Fitzgerald, RD
AF Oczenski, W
   Waldenberger, F
   Nehrer, G
   Kneifel, W
   Swoboda, H
   Schwarz, S
   Fitzgerald, RD
TI Vacuum-assisted closure for the treatment of cervical and mediastinal
   necrotizing fasciitis
SO JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
LA English
DT Article
DE vacuum-assisted closure; necrotizing fasciitis; mediastinitis;
   complications; infections; wound treatment; sepsis
ID WOUND CONTROL
AB NECROTIZING FASCIITIS is a rare but life-threatening infection of the soft tissue that is characterized by widespread fascial necrosis sparing the skin and the underlying muscle. The clinical course is often characterized by a severe hyperacute sepsis and a very high mortality rate of up to 70%.(1-3) Localization in the neck is rare and usually occurs secondary to dental, pharyngeal, and tonsillar infections. Crucial in treatment is the early recognition of the disease and immediate aggressive surgical treatment.(4) The course of the disease is often complicated by the great amount of necrotic tissue causing infection and mutilation.
   The authors report a case of cervical necrotizing fasciitis arising from a peritonsillar abscess complicated by severe mediastinitis and septic shock and, for the first time in this context, the successful use of a vacuum-assisted closure technique as an adjunctive wound treatment.
C1 Vienna City Hosp Lainz, Dept Anesthesia & Intens Care, A-1130 Vienna, Austria.
   Lainz Hosp, Dept Cardiac Surg, Vienna, Austria.
   Lainz Hosp, Dept Plast Surg, Vienna, Austria.
   Lainz Hosp, Dept Otorhinolaryngol, Vienna, Austria.
   Ludwig Boltzmann Inst Econ Med Anesthesia & Inten, Vienna, Austria.
C3 Ludwig Boltzmann Institute; Ludwig Boltzmann Institute for Clinical
   Anesthesia & Intensive Care
RP Oczenski, W (通讯作者)，Vienna City Hosp Lainz, Dept Anesthesia & Intens Care, Wolkersbergenstr 1, A-1130 Vienna, Austria.
EM wolfgang.oczenski@wienkav.at
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banerjee AR, 1996, J LARYNGOL OTOL, V110, P81, DOI 10.1017/S0022215100132797
   Bilton BD, 1998, AM SURGEON, V64, P397
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   Hersh RE, 2001, HEART SURG FORUM, V4, P211
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   Molnar JA, 2000, PLAST RECONSTR SURG, V105, P174, DOI 10.1097/00006534-200001000-00030
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   SCOTT PMJ, 1994, J LARYNGOL OTOL, V108, P435, DOI 10.1017/S002221510012701X
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 11
TC 19
Z9 27
U1 0
U2 0
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 1053-0770
J9 J CARDIOTHOR VASC AN
JI J. Cardiothorac. Vasc. Anesth.
PD JUN
PY 2004
VL 18
IS 3
BP 336
EP 338
DI 10.1053/j.jvca.2004.03.016
PG 3
WC Anesthesiology; Cardiac & Cardiovascular Systems; Respiratory System;
   Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Cardiovascular System & Cardiology; Respiratory System
GA 840MR
UT WOS:000222863400016
PM 15232816
DA 2026-07-24
ER
PT J
AU Antony, S
   Terrazas, S
AF Antony, S
   Terrazas, S
TI A retrospective study: Clinical experience using vacuum-assisted closure
   in the treatment of wounds
SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
LA English
DT Article
DE wound VAC; wound healing
ID NEGATIVE-PRESSURE; TRIAL
AB We report the results of our wound care experience using the wound vac as an adjunct therapy in the treatment of sternal, spinal, and lower-extremity wounds. This is a retrospective study in which 42 patients were evaluated between 1999 and 2002 for nonhealing sternal, spinal, and lower-extremity wounds. There were 12 patients With sternal wounds with a variety of pathogens who were treated with antimicrobials along with the wound VAC. The VAC was applied for an average of 12 days, and all 12 patients went onto complete closure by the end of four weeks. There were 14 patients in the lower-extremity wound group, again, with a variety of pathogens. The VAC was placed for an average of 29.3 days to achieve closure along with the wound VAC. There were 16 spinal wound patients with a variety of pathogens. All the patients received antimicrobial therapy, with the average duration of the VAC beings 27.6 days and closure taking about eight weeks. The wound VAC, along with appropriate antimicrobial therapy and surgery, appears to help reduce the number of days to healing, along with a reduction in the number hospital days and possibly costs to the health system.
C1 Texas Tech Univ, Ctr Hlth Sci, US Oncol PA, El Paso, TX USA.
   Diamond Rehabil Ctr, El Paso, TX USA.
C3 Texas Tech University System; Texas Tech University
RP Antony, S (通讯作者)，7848 Gateway E, El Paso, TX 79935 USA.
EM santony@elp.rr.com
CR Argenta L, 1993, JOINT M WOUND HEAL S
   ARGENTA LC, 1997, WOUND CARE, P29
   Argenta LC, 1997, WOUND CARE, V30-31
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   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
   Yuan-Innes M. J., 2001, Spine, V26, pE1
NR 19
TC 20
Z9 33
U1 0
U2 1
PU NATL MED ASSOC
PI WASHINGON
PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA
SN 0027-9684
J9 J NATL MED ASSOC
JI J. Natl. Med. Assoc.
PD AUG
PY 2004
VL 96
IS 8
BP 1073
EP 1077
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 840QL
UT WOS:000222874100021
PM 15303413
DA 2026-07-24
ER
PT J
AU Etöz, A
   Özgenel, Y
   Özcan, M
AF Etöz, A
   Özgenel, Y
   Özcan, M
TI The use of negative pressure wound therapy on diabetic foot ulcers: A
   preliminary controlled trial
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EXPERIENCE; DEGLOVING INJURIES
AB The purpose of this clinical study was to investigate the effects of negative pressure wound therapy (NPWT) on the healing of diabetic foot ulcers and to compare this dressing with traditional moist gauze dressing as a treatment used prior to other wound closure techniques, such as flaps or grafts. Twenty-four diabetic patients were randomly divided into two groups: NPWT group and control group. Initially, the mean surface area of the diabetic wounds was 109cm(2) in the NPWT group and 94.8cm(2) in the control group. The mean duration of wound care (until the wounds were covered with granulation tissue) was 11.25 days in the NPWT group and 15.75 in the control group (p=0.05); following NPWT or moist guaze dressing, the mean surface area of the wounds was 88.6cm(2) in NPWT group and 85.3 cm(2) in control group (p<0.05). In conclusion, the use of NPWT may be an alternative therapy to achieve a faster granulating wound bed in diabetic foot ulcers in order to prepare the wound bed for other closure techniques. Further studies are needed to clarify effects and indications and to modify the technique of this treatment for nonhealing wounds.
C1 Uludag Univ, Fac Med, Dept Plast & Reconstruct Surg, TR-16059 Gorukle, Bursa, Turkey.
C3 Uludag University
RP Etöz, A (通讯作者)，Uludag Univ, Fac Med, Dept Plast & Reconstruct Surg, TR-16059 Gorukle, Bursa, Turkey.
EM etoz@yahoo.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   ATTINGER CE, 1997, GRABB SMITHS PLASTIC
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
   de Lange MY, 2000, EUR J PLAST SURG, V23, P178, DOI 10.1007/s002380050244
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   DeFranzo AJ, 1999, PLAST RECONSTR SURG, V104, P2145, DOI 10.1097/00006534-199912000-00031
   Joseph E, 2000, WOUNDS, V12, P60
   Josty IC, 2001, BRIT J PLAST SURG, V54, P363, DOI 10.1054/bjps.2000.3565
   Kirby JP, 2002, J TRAUMA, V53, P117, DOI 10.1097/00005373-200207000-00024
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
NR 13
TC 47
Z9 56
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2004
VL 16
IS 8
BP 264
EP 269
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 849AG
UT WOS:000223509000003
DA 2026-07-24
ER
PT J
AU Shilt, JS
   Yoder, JS
   Manuck, TA
   Jacks, L
   Rushing, J
   Smith, BP
AF Shilt, JS
   Yoder, JS
   Manuck, TA
   Jacks, L
   Rushing, J
   Smith, BP
TI Role of vacuum-assisted closure in the treatment of pediatric lawnmower
   injuries
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE lawnmower injuries; vacuum-assisted closure; pediatric trauma; soft
   tissue defects
ID LAWN-MOWER INJURIES; LOWER-EXTREMITY; DEGLOVING INJURIES; WOUND CONTROL;
   CHILDREN; MANAGEMENT; AMPUTATION; PRESSURE; FOOT
AB Lawnmower injuries in children often present treatment challenges due to complex soft tissue damage. Vacuum-assisted closure (VAC), the application of controlled subatmospheric pressure to a wound surface, has been used to treat complex lacerations in many patients and has been shown to be safe and effective in children. However, VAC treatment of lawnmower injuries in children has not been reported. This study analyzes the outcomes of treatment following the use of VAC in children with lawnmower injuries and compares the results of VAC treatment to historical controls who were treated before VAC was available for wound treatment. The use of VAC demonstrated a trend toward a decrease in revision amputations and an improvement in function after treatment. There were no complications or adverse reactions related to VAC treatment. The VAC system is a safe and effective method of treating soft tissue injuries resulting from lawnmower accidents in children.
C1 Wake Forest Univ, Sch Med, Dept Orthopaed Surg, Winston Salem, NC USA.
   Wake Forest Univ, Sch Med, Dept Publ Hlth Sci, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest University
RP Shilt, JS (通讯作者)，Wake Forest Univ, Sch Med, Dept Orthopaed, Winston Salem, NC 27157 USA.
EM jshilt@wfubmc.edu
OI Manuck, Tracy/0000-0002-2465-6747
CR ALONSO JE, 1995, J PEDIATR ORTHOPED, V15, P83, DOI 10.1097/01241398-199501000-00018
   ANGER DM, 1995, J BONE JOINT SURG AM, V77A, P719, DOI 10.2106/00004623-199505000-00008
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   DeFranzo AJ, 1999, PLAST RECONSTR SURG, V104, P2145, DOI 10.1097/00006534-199912000-00031
   DORMANS JP, 1995, J PEDIATR ORTHOPED, V15, P78, DOI 10.1097/01241398-199501000-00017
   Erdmann D, 2000, ANN PLAS SURG, V45, P595, DOI 10.1097/00000637-200045060-00004
   Fabian TS, 2000, AM SURGEON, V66, P1136
   Farley FA, 1996, J PEDIATR ORTHOPED, V16, P669, DOI 10.1097/01241398-199609000-00023
   Gaglani MJ, 1996, PEDIATR INFECT DIS J, V15, P452, DOI 10.1097/00006454-199605000-00014
   HOROWITZ JH, 1985, J TRAUMA, V25, P1138, DOI 10.1097/00005373-198512000-00004
   JOHNSTONE BR, 1989, AUST NZ J SURG, V59, P713, DOI 10.1111/j.1445-2197.1989.tb01663.x
   Kroening L, 2000, Orthop Nurs, V19, P29, DOI 10.1097/00006416-200019020-00006
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   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 23
TC 30
Z9 42
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-6798
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD SEP-OCT
PY 2004
VL 24
IS 5
BP 482
EP 487
DI 10.1097/01241398-200409000-00006
PG 6
WC Orthopedics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Pediatrics
GA 849YA
UT WOS:000223576400006
PM 15308896
DA 2026-07-24
ER
PT J
AU Moisidis, E
   Heath, T
   Boorer, C
   Ho, K
   Deva, AK
AF Moisidis, E
   Heath, T
   Boorer, C
   Ho, K
   Deva, AK
TI A prospective, blinded, randomized, controlled clinical trial of topical
   negative pressure use in skin grafting
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; COMPLICATIONS; EXPERIENCE;
   DEVICE
AB Topical negative pressure has been demonstrated to improve graft take in a number of noncomparative studies. This study aimed to assess whether split-thickness skin graft take is improved qualitatively or quantitatively with topical negative pressure therapy compared with standard bolster dressings. A blinded, prospective, randomized trial was conducted of 22 adult inpatients of Liverpool Hospital between July of 2001 and July of 2002 who had wounds requiring skin grafting. After grafting, each wound half was randomized to receive either a standard bolster dressing or a topical negative pressure dressing. Skin graft assessment was performed at 2 weeks by a single observer blinded to the randomization. Two patients were lost to follow-up and were excluded from the study. There were 20 patients (12 men and eight women) in the study group. The median patient age was 64 years (range, 27 to 88 years), and the mean wound size was 128 cm(2) (range, 35 to 450 cm(2)). The wound exposed subcutaneous fat in eight patients, muscle in six patients, paratenon in four patients, and deep fascia in two patients. At 2 weeks, wounds that received a topical negative pressure dressing had a greater degree of epithelialization in six cases (30 percent), the same degree of epithelialization in nine cases (45 percent), and less epithelialization in five cases (25 percent) compared with their respective control wounds. Graft quality following topical negative pressure therapy was subjectively determined to be better in 10 cases (50 percent), equivalent in seven cases (35 percent), and worse in three cases (15 percent). Although the quantitative graft take was not significant, the qualitative graft take was found to be significantly better with the use of topical negative pressure therapy (p < 0.05). Topical negative pressure significantly improved the qualitative appearance of split-thickness skin grafts as compared with standard bolster dressings.
C1 Liverpool Hosp, Dept Plast & Maxillofacial Surg, Sydney, NSW, Australia.
C3 Liverpool Hospital
RP Deva, AK (通讯作者)，26 Gibbs St,Suite 7, Miranda, NSW 2228, Australia.
OI Deva, Anand/0000-0002-0314-7177
CR Altman D, 1991, PRACTIAL STAT MED RE
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Deva AK, 2000, MED J AUSTRALIA, V173, P128, DOI 10.5694/j.1326-5377.2000.tb125564.x
   Evans D, 2001, BRIT J PLAST SURG, V54, P238, DOI 10.1054/bjps.2001.3547
   Fenn CH, 2001, BRIT J PLAST SURG, V54, P348, DOI 10.1054/bjps.2000.3552
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
   Greer SE, 1999, ANN PLAS SURG, V43, P551, DOI 10.1097/00000637-199911000-00016
   Meara JG, 1999, ANN PLAS SURG, V42, P589, DOI 10.1097/00000637-199906000-00002
   Molnar JA, 2000, PLAST RECONSTR SURG, V105, P174, DOI 10.1097/00006534-200001000-00030
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
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   Sposato G, 2001, BRIT J PLAST SURG, V54, P235, DOI 10.1054/bjps.2000.3537
   Wu SH, 2000, EUR J PLAST SURG, V23, P174, DOI 10.1007/s002380050243
NR 16
TC 228
Z9 266
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP 15
PY 2004
VL 114
IS 4
BP 917
EP 922
DI 10.1097/01.PRS.0000133168.57199.E1
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 851NY
UT WOS:000223693000016
PM 15468399
DA 2026-07-24
ER
PT J
AU Yousaf, M
   Witherow, A
   Gardiner, KR
   Gilliland, R
AF Yousaf, M
   Witherow, A
   Gardiner, KR
   Gilliland, R
TI Use of vacuum-assisted closure for healing of a persistent perineal
   sinus following panproctocolectomy: Report of a case
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE perineal sinus; negative pressure dressing; vacuum-assisted closure
ID INFLAMMATORY BOWEL-DISEASE; RECTAL EXCISION; MUSCLE FLAP; MANAGEMENT;
   PROCTECTOMY
AB Perineal sinus is a troublesome complication after proctectomy for inflammatory bowel disease or rectal cancer. The results from treatment with simple dressings with or without surgical debridement are suboptimal. Definitive management may require complex operations with muscular or musculocutaneous flaps. Vacuum-assisted dressings have been used successfully for management of chronic wounds and soft tissue defects. This technique was successfully used in the management of a perineal sinus, which occurred after proctectomy for rectal cancer developing on a background of inflammatory bowel disease and preoperative radiotherapy.
C1 Altnagelvin Hosp, Dept Surg, Derry BT47 6SB, Londonderry, North Ireland.
   Royal Victoria Hosp, Dept Surg, Belfast BT12 6BA, Antrim, North Ireland.
RP Gilliland, R (通讯作者)，Altnagelvin Hosp, Dept Surg, Glenshane Rd, Derry BT47 6SB, Londonderry, North Ireland.
EM rgilliland@alt.n.nhs.uk
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ARGENTA LC, 1993, 25 ANN C WOUND OST C
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   SILEN W, 1974, SURGERY, V75, P535
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   TOMPKINS RG, 1985, ANN SURG, V202, P760, DOI 10.1097/00000658-198512000-00016
   Yamamoto T, 1999, DIS COLON RECTUM, V42, P96, DOI 10.1007/BF02235190
NR 24
TC 20
Z9 25
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD AUG
PY 2004
VL 47
IS 8
BP 1403
EP 1407
DI 10.1007/s10350-004-0576-1
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 852JJ
UT WOS:000223751300020
PM 15484357
DA 2026-07-24
ER
PT J
AU Ohye, RG
   Maniker, RB
   Graves, HL
   Devaney, EI
   Bove, EL
AF Ohye, RG
   Maniker, RB
   Graves, HL
   Devaney, EI
   Bove, EL
TI Primary closure for postoperative mediastinitis in children
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 83rd Annual Meeting of the American-Association-for-Thoracic-Surgery
CY MAY 04-07, 2003
CL BOSTON, MA
SP Amer Assoc Thorac Surg
ID STERNAL WOUND-INFECTION; MUSCLE FLAP; RISK-FACTORS; MANAGEMENT; SURGERY;
   RECONSTRUCTION; COMPLICATION; OPERATION
AB Objectives: Mediastinitis affects approximately 1% of children undergoing median sternotomy. Conventional therapy involves debridement followed by open wound care with delayed closure, days to weeks of closed suction or antimicrobial irrigation, and vacuum-assisted closure or muscle flap closure. We hypothesized that primary closure without prolonged suction or irrigation is an effective, less traumatic treatment for mediastinitis in children.
   Methods: From January 1986 to July 2002, 6705 procedures involving median sternotomy were performed at the C. S. Mott Children's Hospital, resulting in 57 cases of mediastinitis (0.85%). Cases were divided into 2 groups, with 42 cases treated with primary closure and 15 cases treated with delayed or muscle flap closure. The 42 cases of primary closure comprised the primary study group of this institutional review board-approved, retrospective analysis. Patient demographics, surgical variables, mediastinitis-related parameters, and outcomes were evaluated.
   Results: One patient had recurrent mediastinitis for an overall infection eradication rate of 97% (40/41). Three patients (7%) required re-exploration for suspected ongoing infection. Of these re-explorations, 1 patient had evidence of continued mediastinitis. The remaining 2 patients with sepsis of unclear cause had no clinical or culture evidence of recurrent infection. One of these patients ultimately died of sepsis without active mediastinitis for a hospital survival of 97% (41/42). No significant differences could be detected between the treatment successes and failures in this small cohort of patients.
   Conclusions: Simple primary closure is an effective means to treat selected cases of postoperative mediastinitis in children. The results compare favorably with other more lengthy or debilitating treatments.
C1 Univ Michigan, Div Pediat Cardiovasc Surg, Sch Med, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Ohye, RG (通讯作者)，F7830 Mott 0223,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM ohye@umich.edu
CR BACKER CL, 1994, ANN THORAC SURG, V57, P797, DOI 10.1016/0003-4975(94)90179-1
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NR 19
TC 25
Z9 32
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD SEP
PY 2004
VL 128
IS 3
BP 480
EP 486
DI 10.1016/j.jtcvs.2004.04.023
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 853UG
UT WOS:000223853800026
PM 15354112
OA Bronze
DA 2026-07-24
ER
PT J
AU Armstrong, DG
   Kunze, K
   Martin, BR
   Kimbriel, HR
   Nixon, BP
   Boulton, AJM
AF Armstrong, DG
   Kunze, K
   Martin, BR
   Kimbriel, HR
   Nixon, BP
   Boulton, AJM
TI Plantar pressure changes using a novel negative pressure wound therapy
   technique
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID DIABETIC FOOT ULCERATION; RISK
AB This study evaluated changes in pressure imparted to diabetic foot wounds using a novel negative pressure bridging technique coupled with a robust removable cast walker. Ten patients had plantar pressures assessed with and without a bridged negative pressure dressing on the foot. Off-loading was accomplished with a pressure-relief walker. Plantar pressures were recorded using two pressure-measurement systems. The location and value of peak focal pressure (taken from six midgait steps) were recorded at the site of ulceration. Paired analysis revealed a large difference (mean +/- SD, 74.6% +/- 6.0%) between baseline barefoot pressure and pressure within the pressure-relief walker (mean +/- SD, 939.1 +/- 195.1 versus 235.7 +/- 66.1 kPa). There was a mean +/- SD 9.9% +/- 5.6% higher pressure in the combination device compared with the pressure-relief walker alone (mean +/- SD, 258.0 +/- 69.7 versus 235.7 66.1 kPa). This difference was only 2% of the initial barefoot pressure imparted to the wound. A modified negative pressure dressing coupled with a robust removable cast walker may not impart undue additional stress to the plantar aspect of the foot and may allow patients to retain some degree of freedom (and a potentially reduced length of hospital stay) while still allowing for the beneficial effects of negative pressure wound therapy and sufficient off-loading.
C1 Rosalind Franklin Univ Med & Sci, Dept Surg, Dr William M Scholl Coll Podiat Med, N Chicago, IL 60064 USA.
   So Arizona Affairs Med Ctr, Dept Surg, Podiatry Sect, Tucson, AZ USA.
   Univ Miami, Diabet Res Inst, Miami, FL 33152 USA.
   Manchester Royal Infirm, Dept Med, Manchester M13 9WL, Lancs, England.
C3 Rosalind Franklin University of Medicine & Science; University of Miami;
   University of Manchester
RP Armstrong, DG (通讯作者)，Rosalind Franklin Univ Med & Sci, Dept Surg, Dr William M Scholl Coll Podiat Med, 3333 Green Bay Rd, N Chicago, IL 60064 USA.
CR Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Armstrong DG, 1998, DIABETES CARE, V21, P855, DOI 10.2337/diacare.21.5.855
   Armstrong DG, 2002, J AM PODIAT MED ASSN, V92, P405, DOI 10.7547/87507315-92-7-405
   Armstrong DG, 2003, DIABETES CARE, V26, P2595, DOI 10.2337/diacare.26.9.2595
   Boulton AJM, 2003, DIABETES CARE, V26, P2689, DOI 10.2337/diacare.26.9.2689
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
   Lavery LA, 1997, ARCH PHYS MED REHAB, V78, P1268, DOI 10.1016/S0003-9993(97)90342-7
   Lavery LA, 1996, DIABETES CARE, V19, P818, DOI 10.2337/diacare.19.8.818
   Lavery LA, 1997, DIABETES CARE, V20, P1706, DOI 10.2337/diacare.20.11.1706
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   Morykwas M J, 1997, J South Orthop Assoc, V6, P279
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Yuan-Innes M J, 2001, Spine (Phila Pa 1976), V26, pE30
NR 13
TC 8
Z9 21
U1 0
U2 3
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD SEP-OCT
PY 2004
VL 94
IS 5
BP 456
EP 460
DI 10.7547/0940456
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 856XH
UT WOS:000224078800004
PM 15377721
DA 2026-07-24
ER
PT J
AU Scholl, L
   Chang, E
   Reitz, B
   Chang, J
AF Scholl, L
   Chang, E
   Reitz, B
   Chang, J
TI Sternal osteomyelitis: Use of vacuum-assisted closure device as an
   adjunct to definitive closure with sternectomy and muscle flap
   reconstruction
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID WOUND COMPLICATIONS; MANAGEMENT; MEDIASTINITIS; EXPERIENCE; BRIDGE
AB Objectives: Sternal osteomyelitis following cardiac surgery often requires debridement and flap coverage. The VAC (vacuum-assisted closure) device has been useful in complex wound coverage. A retrospective review of a single surgeon's experience with sternal reconstruction using the VAC device as an adjunct to debridement and muscle flap reconstruction was performed. Methods: Thirteen consecutive patients over a 34-month period underwent debridement and reconstruction of sternal wounds. Eleven patients (85%) were males, and two (15%) were females. Mean age was 61 years (range: 43-73 years). Acute purulent sternal infections occurred in seven patients, while chronic sternal osteomyelitis was seen in six patients. Use of the VAC device during the perioperative period was evaluated. Results: Of the 13 patients, the VAC device was used prior to flap closure in six patients, and after flap closure in two patients. Sternal debridement with bilateral pectoralis muscle flaps was used to reconstruct 12 patients, and one patient underwent debridement only with VAC placement. All 13 patients (100%) had complete closure of their complex wounds at an average of follow-up of 14 months. Conclusions: The VAC device is useful in the treatment of sternal osteomyelitis in three contexts: (1) as a temporary wound care technique preoperatively that minimizes dressing changes and prevents shear stresses of an open sternum, (2) as the sole method of wound closure in specific cases, and (3) as a technique to facilitate healing in postoperative flap reconstruction cases complicated by reinfection.
C1 Stanford Univ, Med Ctr, Div Plast & Reconstruct Surg, Dept Surg, Stanford, CA USA.
   Stanford Univ, Med Ctr, Dept Cardiothorac Surg, Stanford, CA USA.
C3 Stanford University; Stanford University
RP Chang, J (通讯作者)，Stanford Univ, Med Ctr, Div Plast Surg, 770 Welch Rd,Suite 400, Stanford, CA 94305 USA.
EM changhand@aol.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ARNOLD PG, 1989, SURG CLIN N AM, V69, P1081
   ARNOLD PG, 1994, PLAST RECONSTR SURG, V93, P324, DOI 10.1097/00006534-199402000-00015
   Golosow LM, 1999, ANN PLAS SURG, V43, P30, DOI 10.1097/00000637-199907000-00005
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Hersh RE, 2001, HEART SURG FORUM, V4, P211
   HUGO NE, 1994, PLAST RECONSTR SURG, V93, P1433, DOI 10.1097/00006534-199406000-00016
   Jones G, 1997, ANN SURG, V225, P766, DOI 10.1097/00000658-199706000-00014
   Lindsey JT, 2002, PLAST RECONSTR SURG, V109, P1882, DOI 10.1097/00006534-200205000-00015
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   PAIROLERO PC, 1986, ANN THORAC SURG, V42, P1, DOI 10.1016/S0003-4975(10)61822-X
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   Tang A T, 2000, J Wound Care, V9, P229
NR 15
TC 42
Z9 53
U1 0
U2 3
PU BLACKWELL FUTURA PUBLISHING, INC
PI MALDEN
PA 350 MAIN STREET, MALDEN, MA 01248-5018 USA
SN 0886-0440
J9 J CARDIAC SURG
JI J. Card. Surg.
PD SEP-OCT
PY 2004
VL 19
IS 5
BP 453
EP 461
DI 10.1111/j.0886-0440.2004.05002.x
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 858LD
UT WOS:000224192400016
PM 15383060
DA 2026-07-24
ER
PT J
AU Tachi, M
   Hirabayashi, S
   Yonehara, Y
   Uchida, G
   Tohyama, T
   Ishii, H
AF Tachi, M
   Hirabayashi, S
   Yonehara, Y
   Uchida, G
   Tohyama, T
   Ishii, H
TI Topical negative pressure using a drainage pouch without foam dressing
   for the treatment of undermined pressure ulcers
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE topical negative pressure; pressure ulcer; undermining
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL
AB Topical negative pressure is gaining popularity as an acute and chronic wound management technique. In general, foam dressing is applied to the wound surface to maintain negative pressure. Due to the potential for clogging by the foam dressing, topical negative pressure cannot be used when there is a high volume of necrotic tissue or massive infection present. In this study, topical negative pressure was applied using a drainage pouch without any dressing. Topical negative pressure was applied to 8 patients with 9 pressure ulcers complicated by undermining. This approach was effective in the treatment of all 9 ulcers and allowed the wounds to be visualized while maintaining negative pressure. Since this technique can be performed without foam dressing, it can be used to treat early-stage infectious pressure ulcers in which there is a lot of necrotic tissue.
   Conclusion: Topical negative pressure without dressing is an extremely effective treatment of pressure ulcers complicated by undermining.
C1 Teikyo Univ, Sch Med, Dept Plast & Reconstruct Surg, Itabashi Ku, Tokyo 1738605, Japan.
C3 Teikyo University
RP Tachi, M (通讯作者)，Teikyo Univ, Sch Med, Dept Plast & Reconstruct Surg, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM tachi@med.teikyo-u.ac.jp
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Bowler PG, 2002, ANN MED, V34, P419, DOI 10.1080/078538902321012360
   Coggrave Maureen, 2002, Br J Nurs, V11, pS29
   de Vooght A, 2003, PLAST RECONSTR SURG, V112, P1188, DOI 10.1097/01.PRS.0000077233.64957.30
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
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   Kercher KW, 2002, OSTOMY WOUND MANAG, V48, P44
   McGuinness JG, 2003, DIS COLON RECTUM, V46, P274, DOI 10.1007/s10350-004-6535-z
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 16
TC 12
Z9 20
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2004
VL 53
IS 4
BP 338
EP 342
DI 10.1097/01.sap.0000129234.84192.d4
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 859ZA
UT WOS:000224305700007
PM 15385767
DA 2026-07-24
ER
PT J
AU Schaffzin, DM
   Douglas, JM
   Stahl, TJ
   Smith, LE
AF Schaffzin, DM
   Douglas, JM
   Stahl, TJ
   Smith, LE
TI Vacuum-assisted closure of complex perineal wounds
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Society-of-Colon-and-Rectal-Surgeons
CY JUN 21-26, 2003
CL NEW ORLEANS, LA
SP Amer Soc Colon & Rectal Surg
DE wound healing; negative pressure dressing; perineal wounds; surgical
   technique
ID SYSTEM; DEVICE
AB The Vacuum-assisted Closure device decreases the time to wound healing, thus increasing the deposition of granulation tissue, and decreasing the use of wound care specialists. Perineal wounds present a special challenge. We present four cases of complex perineal wounds in which the Vacuum-assisted Closure device was used. In each case, wound care was simplified and healing accelerated. The Vacuum-assisted Closure device allows earlier wound closure, early skin grafting (with improved graft adherence), earlier hospital discharge, and earlier return to baseline functional status. its use in the perineum presents a challenge, but with proper application, even the most complex perineal wounds can be healed.
C1 Washington Hosp Ctr, Sect Colon & Rectal Surg, Washington, DC 20010 USA.
C3 MedStar Washington Hospital Center
RP Schaffzin, DM (通讯作者)，714 Chanticleer, Cherry Hill, NJ 08003 USA.
EM fap5q@yahoo.com
CR Cro C, 2002, POSTGRAD MED J, V78, P364, DOI 10.1136/pmj.78.920.364
   Fabian TS, 2000, AM SURGEON, V66, P1136
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
   HANLON M, 2001, JWOCN, V28, P171
   Harlan JW, 2002, PLAST RECONSTR SURG, V109, P710, DOI 10.1097/00006534-200202000-00045
   HUTCHINSON L, 1999, J WORLD COUNCIL ENTE, V19, P17
   McGuinness JG, 2003, DIS COLON RECTUM, V46, P274, DOI 10.1007/s10350-004-6535-z
   Rosser CJ, 2000, INFECT UROL, V13, P45
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Sposato G, 2001, BRIT J PLAST SURG, V54, P235, DOI 10.1054/bjps.2000.3537
NR 10
TC 42
Z9 54
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD OCT
PY 2004
VL 47
IS 10
BP 1745
EP 1748
DI 10.1007/s10350-004-0633-9
PG 4
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology; Surgery
GA 860JD
UT WOS:000224337600030
PM 15540310
DA 2026-07-24
ER
PT J
AU Saxena, V
   Hwang, CW
   Huang, S
   Eichbaum, Q
   Ingber, D
   Orgill, DP
AF Saxena, V
   Hwang, CW
   Huang, S
   Eichbaum, Q
   Ingber, D
   Orgill, DP
TI Vacuum-assisted closure: Micro deformations of wounds and cell
   proliferation
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID ENDOTHELIAL-CELLS; SHEAR-STRESS; GROWTH; SHAPE; FIBRONECTIN; ACTIVATION;
   GRADIENTS; MODEL
AB The mechanism of action Of the Vacuum Assisted Closure Therapy (VAC; KCl, San Antonio, Texas), a recent novel innovation in the care of wounds, remains unknown. In vitro studies have revealed that cells allowed to stretch tend to divide and proliferate in the presence of soluble mitogens, whereas retracted cells remain quiescent. The authors hypothesize that application of micro-mechanical forces to wounds in vivo can promote wound healing through this cell shape-dependent, mechanical control mechanism. The authors created a computer model (finite element) of a wound and simulated VAC application. Finite element modeling is coin in only used to engineer complex systems by breaking them down into simple discrete elements. In this model, the authors altered the pressure, pore diameter, and pore volume fraction to study the effects of vacuum-induced material deformations. The authors compared the morphology of deformation of this wound model with histologic sections of wounds treated with the VAC The finite element model showed that most elements stretched by VAC application experienced deformations of 5 to 20 percent strain, which are similar to in vitro strain levels shown to promote cellular proliferation. Importantly, the deformation predicted by the model also was similar in morphology to the surface undulations observed in histologic cross-sections of the wounds. The authors hypothesize that this tissue deformation stretches individual cells, thereby promoting proliferation in the wound microenvironment. The application of micromechanical forces may be a useful method with which to stimulate wound healing through promotion of cell division, angiogenesis, and local elaboration of growth factors. Finite element modeling of the VAC device is consistent with this mechanism of action.
C1 Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Surg,Div Plast Surg, Boston, MA 02115 USA.
   Harvard Univ, Childrens Hosp, Sch Med, Dept Surg,Vasc Biol Program, Boston, MA 02115 USA.
   Harvard Univ, Childrens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA.
   MIT, Dept Mech Engn, Cambridge, MA 02139 USA.
   MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
   Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cambridge, MA 02138 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital; Harvard
   Medical School; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Boston Children's Hospital; Massachusetts
   Institute of Technology (MIT); Massachusetts Institute of Technology
   (MIT); Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital
RP Saxena, V (通讯作者)，Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Surg,Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
RI Ingber, Donald/AAC-5894-2019; Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
FU NCI NIH HHS [CA 45548] Funding Source: Medline
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NR 25
TC 545
Z9 666
U1 0
U2 31
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2004
VL 114
IS 5
BP 1086
EP 1096
DI 10.1097/01.prs.0000135330.51408.97
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 861DQ
UT WOS:000224396700009
PM 15457017
DA 2026-07-24
ER
PT J
AU Wackenfors, A
   Sjögren, J
   Gustafsson, R
   Algotsson, L
   Ingemansson, R
   Malmsjö, M
AF Wackenfors, A
   Sjögren, J
   Gustafsson, R
   Algotsson, L
   Ingemansson, R
   Malmsjö, M
TI Effects of vacuum-assisted closure therapy on inguinal wound edge
   microvascular blood flow
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID PRESSURE; TISSUE; EXPERIENCE
AB Vacuum-assisted closure (VAC) therapy has been shown to facilitate wound healing. Data on the mechanisms are scarce, although beneficial effects on blood flow and granulation tissue formation have been presented. In the current study, laser Doppler was used to measure microvascular blood flow to an inguinal wound in pigs during VAC therapy (- 50 to - 200 mmHg), including consideration of the different tissue types and the distance from the wound edge. VAC treatment induced an increase in microvascular blood flow a few centimeters from the wound edge. The increase in blood flow occurred closer to the wound edge in muscular as compared to subcutaneous tissue (1.5 cm and 3 cm, at - 75 mmHg). In the immediate proximity to the wound edge, blood flow was decreased. This hypoperfused zone was increased with decreasing pressure and was especially prominent in subcutaneous as compared to muscular tissue (0-1.9 cm vs. 0-1.0 cm, at - 100 mmHg). When VAC therapy was terminated, blood flow increased multifold, which may be due to reactive hyperemia. In conclusion, VAC therapy affects microvascular blood flow to the wound edge and may thereby promote wound healing. A low negative pressure during treatment may be beneficial, especially in soft tissue, to minimize possible ischemic effects. Intermittent VAC therapy may further increase blood flow.
C1 Univ Lund Hosp, Dept Internal Med, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Anesthesia, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Wackenfors, A (通讯作者)，Expt Vasc Res, BMC A13, SE-22184 Lund, Sweden.
EM angelica.wackenfors@med.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599
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NR 22
TC 227
Z9 314
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2004
VL 12
IS 6
BP 600
EP 606
DI 10.1111/j.1067-1927.2004.12602.x
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 870AU
UT WOS:000225027200002
PM 15555050
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Banwell, PE
AF Banwell, PE
TI Topical negative pressure therapy: Advances in burn wound management
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P E, 2003, J Wound Care, V12, P22
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NR 18
TC 0
Z9 0
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2004
SU A
BP 9S
EP 14S
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 875YA
UT WOS:000225457800004
DA 2026-07-24
ER
PT J
AU Orgill, DP
AF Orgill, DP
TI Utilizing negative pressure wound therapy on open chest/sternotomy
   wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MEDIAN STERNOTOMY; INFECTION
RI Orgill, Dennis/H-7596-2019
CR *AM HEART ASS, 2004, OP HEART SURG STAT S
   [Anonymous], J THORAC CARDIOVASC
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NR 17
TC 6
Z9 12
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2004
SU A
BP 15S
EP 17S
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 875YA
UT WOS:000225457800005
PM 15632461
DA 2026-07-24
ER
PT J
AU Kaplan, M
AF Kaplan, M
TI Negative pressure wound therapy in the management of abdominal
   compartment syndrome
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID CLOSURE; SECONDARY; TRAUMA
CR Adams JM, 2001, J TRAUMA, V50, P792, DOI 10.1097/00005373-200105000-00004
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 22
TC 11
Z9 17
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2004
SU A
BP 20S
EP 25S
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 875YA
UT WOS:000225457800007
PM 15632463
DA 2026-07-24
ER
PT J
AU Baharestani, MM
AF Baharestani, MM
TI Negative pressure wound therapy: An examination of cost-effectiveness
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
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NR 27
TC 5
Z9 11
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2004
SU A
BP 29S
EP 33S
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 875YA
UT WOS:000225457800009
PM 15632465
DA 2026-07-24
ER
PT J
AU Stone, PA
   Hass, SM
   Flaherty, SK
   DeLuca, JA
   Lucente, FC
   Kusminsky, RE
AF Stone, PA
   Hass, SM
   Flaherty, SK
   DeLuca, JA
   Lucente, FC
   Kusminsky, RE
TI Vacuum-assisted fascial closure for patients with abdominal trauma
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE abdominal compartment syndrome; open abdomen; vacuum closure; Bogota
   closure
ID PACK TECHNIQUE; WALL; PERITONITIS; EXPERIENCE; MANAGEMENT; RETENTION;
   PRESSURE; FAILURE; ABDOMEN; MARLEX
AB Background: Massive fluid resuscitation often is required for patients with intraabdominal trauma. Subsequently, fascial closure is not always possible in this subset of patients. Under these circumstances, an initial step can be the use of a temporary abdominal closure method. The authors currently use a vacuum-assisted closure to manage the open abdomen for some of their trauma patients. They present their experience over the past 3 years.
   Methods: From January 2000 to December 2002, 48 trauma patients were treated with temporary abdominal closure using a vacuum-assisted dressing. The ultimate management of the abdominal defect, the serum lactate levels measured in the emergency department, and the fluid balance at the last attempt to accomplish fascial closure were reviewed.
   Results: Delayed fascial closure was achieved in 23 (71.9%) of 32 patients who survived to discharge (26 of 48, 54.2%). Of the 32 patients who survived to discharge, 9 (28.1%) required an alternative closure, most often a split-thickness skin graft. Of the 16 patients who died before discharge, 8 died within 24 hours after admission. Whereas 5 of the 16 deaths occurred after delayed abdominal closure, 11 patients died without abdominal closure. Emergency department serum lactate levels above 8 mg/dL show a positive correlation with in-hospital mortality (6 of 16 patients; 38%; p = 0.001) and mortality within 24 hours of admission (6 of 8 patients; 75%; p = 0.003). Admission lactate levels were not associated with the type of closure achieved. However, primary closure was associated with a significant decrease in lactate levels during the first 12 hours. Complications included five abdominal abscesses, two enterocutaneous fistulas, and one split-thickness skin graft failure.
   Conclusion:. Patients requiring temporary abdominal closure have a significant in-hospital mortality rate of 33%. Delayed primary closure with vacuum assistance was achieved for 71.9% of the surviving patients. Maintaining a negative or total positive fluid balance of less than 20 L before the last attempted fascial closure improves successful closure rates, as seen in 19 of 22 patients (86.4%). The vacuum-assisted closure technique also enabled successful primary closure for two patients with extreme delay (>8 days). Elevated serum lactate levels are significantly correlated with early and in-hospital mortality. A significant decrease in lactate level during the first 12 hours is associated with achievement of primary closure.
C1 W Virginia Univ, CAMC Hlth Educ & Res Inst, Dept Surg, Sch Med, Charleston, WV 25304 USA.
C3 West Virginia University
RP Flaherty, SK (通讯作者)，W Virginia Univ, CAMC Hlth Educ & Res Inst, Dept Surg, Sch Med, 3211 MacCorkle Ave SE, Charleston, WV 25304 USA.
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NR 21
TC 95
Z9 109
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD NOV
PY 2004
VL 57
IS 5
BP 1082
EP 1086
DI 10.1097/01.TA.0000149248.02598.9E
PG 5
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 878QD
UT WOS:000225660600026
PM 15580036
DA 2026-07-24
ER
PT J
AU Connolly, TP
AF Connolly, TP
TI Necrotizing surgical site infection after tension-free vaginal tape
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID OBESE PATIENTS; SURGERY
AB BACKGROUND: Infectious morbidity after tension-free vaginal tape (FVT) treatment of urinary stress incontinence may be a potential concern.
   CASE: A 53-year-old obese woman with a 7-year history of urinary incontinence consented to TVT placement. Two days after discharge the patient presented with suspected cellulitis. Dicloxacillin, ciprofloxacin, ampicillin/sulbactam, and metronidazole were ineffective. Removal of the tape, surgical debridement, dressing changes, ceftriaxone, and clindamycin followed by levofloxacin and metronidazole, repeat wound debridement, and vacuum assisted closure were required. Frozen section revealed gangrenous soft tissue with areas of skin necrosis, but no fasciitis.
   CONCLUSION: This is the first case of necrotizing surgical site infection after TVT placement. Infectious morbidity risks need to be considered in these procedures. (C) 2004 by The American College of Obstetricians and Gynecologists.
C1 Wausau Ctr, Marshfield Clin, Dept Obstet & Gynecol, Wausau, WI 54401 USA.
C3 Marshfield Clinic
RP Connolly, TP (通讯作者)，Wausau Ctr, Marshfield Clin, Dept Obstet & Gynecol, 2727 Plaza Dr, Wausau, WI 54401 USA.
EM connolly.thomas@marshfieldclinic.org
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TC 23
Z9 28
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD DEC
PY 2004
VL 104
IS 6
BP 1275
EP 1276
DI 10.1097/01.AOG.0000146284.62793.8f
PG 2
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 878YL
UT WOS:000225683400012
PM 15572489
DA 2026-07-24
ER
PT J
AU Orgill, DP
   Austen, WG
   Butler, CE
   Fine, NA
   Horvath, KA
   Mihaljevic, T
   Song, DH
   Wolfe, WG
AF Orgill, DP
   Austen, WG
   Butler, CE
   Fine, NA
   Horvath, KA
   Mihaljevic, T
   Song, DH
   Wolfe, WG
TI Guidelines for treatment of complex chest wounds with negative pressure
   wound pressure wound therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; OPEN-HEART-SURGERY; ARTERY-BYPASS-SURGERY;
   CARDIAC SURGICAL-PROCEDURES; MODIFIED ELOESSER FLAP; RAT
   SKELETAL-MUSCLE; RISK-FACTORS; MEDIAN STERNOTOMY; GRAFT-SURGERY;
   POSTSTERNOTOMY MEDIASTINITIS
AB Complex chest wounds front trauma, infection, tumor, and post-surgical complications provide challenges to sui-cons because of the vital structures within the thorax. Median sternotomy is the most common cause of complex chest wounds. An expert panel of cardiac and plastic surgeons reviewed the medical literature oil complex chest wounds using an evidence-based approach. Negative pressure wound therapy (NPWT) is an increasingly common modality to treat complex chest wounds. Evidence to date demonstrates that NPWT is a safe and effective modality for treating complex chest wounds. Reports indicate that NPWT removes wound exudates, stimulates granulation tissue formation, and reduces the number of dressing changes. In general, NPWT is used as a bridge to surgical closure but. is occasionally used as a primary wound treatment. Further studies are needed to better understand the mechanism of action, optimize utilization protocols, and demonstrate the cost effectiveness of this new technology.
RI Orgill, Dennis/H-7596-2019
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NR 130
TC 10
Z9 33
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2004
SU B
BP 1
EP 23
PG 23
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 885FO
UT WOS:000226142700001
DA 2026-07-24
ER
PT J
AU White, RA
   Miki, RA
   Kazmier, P
   Anglen, JO
AF White, RA
   Miki, RA
   Kazmier, P
   Anglen, JO
TI Vacuum-assisted closure complicated by erosion and hemorrhage of the
   anterior tibial artery
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE vacuum-assisted; erosion; hemorrhage; fracture; artery
ID SECURING SKIN-GRAFTS; NEGATIVE-PRESSURE; SUBATMOSPHERIC PRESSURE;
   RELIABLE METHOD; WOUND CONTROL; THERAPY; EXPERIENCE; DEVICE; TRAUMA;
   SYSTEM
AB We report an erosion and hemorrhage of a left anterior tibial artery associated with a vacuum-assisted closure device. To our knowledge, this report represents the first arterial erosion associated with a vacuum-assisted closure device. We estimate our patient lost 6 units of blood. The hemorrhage was complicated by anticoagulation and a traumatic setting. Based on our complication, we believe great care should be taken when placing a vacuum-assisted closure device adjacent to an exposed artery.
C1 Boone Orthopaed Associates, Columbia, MO 65201 USA.
   Univ Missouri, Univ Hosp, Dept Orthopaed Surg, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia
RP Anglen, JO (通讯作者)，Boone Orthopaed Associates, Broadway Med Plaza,1601 E Broadway,Suite 300, Columbia, MO 65201 USA.
EM anglenj@health.missouri.edu
OI Anglen, Jeffrey/0000-0001-9910-6611
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NR 29
TC 59
Z9 91
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD JAN
PY 2005
VL 19
IS 1
BP 56
EP 59
DI 10.1097/00005131-200501000-00011
PG 4
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 888TR
UT WOS:000226397600011
PM 15668586
DA 2026-07-24
ER
PT J
AU Fuchs, U
   Zittermann, A
   Stuettgen, B
   Groening, A
   Minami, K
   Koerfer, R
AF Fuchs, U
   Zittermann, A
   Stuettgen, B
   Groening, A
   Minami, K
   Koerfer, R
TI Clinical outcome of patients with deep sternal wound infection managed
   by vacuum-assisted closure compared to conventional therapy with open
   packing: A retrospective analysis
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID PRESSURE SUCTION DRAINAGE; POSTSTERNOTOMY MEDIASTINITIS;
   CARDIAC-SURGERY; STERNOTOMY
AB Background. It is suggested that the vacuum technique is a promising new method for the therapy of mediastinitis, but reliable investigations are currently almost completely lacking. We therefore compared clinical outcome of patients whose sternal infection was managed with the vacuum-assisted closure system or with the conventional procedure of open packing.
   Methods. We performed a retrospective analysis in 68 cases of sternal wound infection that were identified at our Heart Center between September 1998 and September 2003. Thirty-five patients could be allocated to the vacuum group and 33 patients to the conventional group. We compared the time interval from sternal infection until freedom of microbiological cultures, in-hospital stay, the status at discharge (rewired or open sternum), the time interval until wound healing was achieved, and survival rates. Moreover, we compared serum levels of C-reactive protein and blood leukocyte counts on admission, at diagnosis of sternal infection, and at different points of time until discharge.
   Results. Baseline characteristics and blood factors did not differ between the two study groups at diagnosis of sternal infection. Moreover, the number of prescribed antibiotics was similar, and the C-reactive protein level and blood leukocyte counts at discharge were comparable in both groups. However, freedom from mediastinal microbiological cultures was achieved earlier (p < 0.01), C-reactive protein levels declined more rapidly (p < 0.025), in-hospital stay was shorter (p < 0.01), rewiring was earlier (p < 0.01), and survival tended to be higher (p < 0.15) in the vacuum group compared to the conventional group.
   Conclusions. This retrospective analysis could demonstrate that the vacuum technique improves the medical outcome of patients with mediastinitis compared with the conventional technique of open packing. (C) 2005 by The Society of Thoracic Surgeons.
C1 Ruhr Univ Bochum, Heart Ctr N Rhine Westfalia, Dept Cardiovasc Surg, D-32545 Bad Oeynhausen, Germany.
   Ruhr Univ Bochum, Heart Ctr N Rhine Westfalia, Dept Lab & Transfus Med, D-32545 Bad Oeynhausen, Germany.
C3 Ruhr University Bochum; Ruhr University Bochum
RP Fuchs, U (通讯作者)，Ruhr Univ Bochum, Heart Ctr N Rhine Westfalia, Dept Cardiovasc Surg, Georgstr 11, D-32545 Bad Oeynhausen, Germany.
EM ufuchs@hdz-nrw.de
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NR 18
TC 102
Z9 122
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD FEB
PY 2005
VL 79
IS 2
BP 526
EP 531
DI 10.1016/j.athoracsur.2004.08.032
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 895GY
UT WOS:000226850200023
PM 15680828
DA 2026-07-24
ER
PT J
AU Gemeinhardt, KD
   Molnar, JA
AF Gemeinhardt, KD
   Molnar, JA
TI Vacuum-assisted closure for management of a traumatic neck wound in a
   horse
SO EQUINE VETERINARY EDUCATION
LA English
DT Article
DE horse; equine; wound; vacuum; subatmospheric pressure; VAC
ID CLINICAL-EXPERIENCE; THERAPY
C1 Latitude 36 Mobile Vet Serv, Germanton, NC USA.
   Wake Forest Univ, Dept Plast & Reconstruct Surg, Sch Med, Winston Salem, NC 27109 USA.
C3 Wake Forest University
RP Gemeinhardt, KD (通讯作者)，Latitude 36 Mobile Vet Serv, POB 466, Germanton, NC USA.
RI Molnar, Joseph/AEK-5540-2022
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   de Lange MY, 2000, EUR J PLAST SURG, V23, P178, DOI 10.1007/s002380050244
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NR 8
TC 34
Z9 43
U1 0
U2 7
PU EQUINE VETERINARY JOURNAL LTD
PI NEWMARKET
PA GRASEBY HOUSE, ENXING ROAD, NEWMARKET CB8 0AU, SUFFOLK, ENGLAND
SN 0957-7734
J9 EQUINE VET EDUC
JI Equine Vet. Educ.
PD FEB
PY 2005
VL 17
IS 1
BP 27
EP 32
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 895JQ
UT WOS:000226857600008
DA 2026-07-24
ER
PT J
AU Orsini, JA
AF Orsini, JA
TI Use of vacuum-assisted closure for management of traumatic wounds
SO EQUINE VETERINARY EDUCATION
LA English
DT Article
C1 Univ Penn, Sch Vet Med, New Bolton Ctr, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Orsini, JA (通讯作者)，Univ Penn, Sch Vet Med, New Bolton Ctr, Philadelphia, PA 19104 USA.
CR Gemeinhardt KD, 2005, EQUINE VET EDUC, V17, P27, DOI 10.1111/j.2042-3292.2005.tb00331.x
NR 1
TC 0
Z9 0
U1 0
U2 2
PU EQUINE VETERINARY JOURNAL LTD
PI NEWMARKET
PA GRASEBY HOUSE, ENXING ROAD, NEWMARKET CB8 0AU, SUFFOLK, ENGLAND
SN 0957-7734
J9 EQUINE VET EDUC
JI Equine Vet. Educ.
PD FEB
PY 2005
VL 17
IS 1
BP 33
EP 33
PG 1
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 895JQ
UT WOS:000226857600009
OA Bronze
DA 2026-07-24
ER
PT J
AU Caniano, DA
   Ruth, B
   Teich, S
AF Caniano, DA
   Ruth, B
   Teich, S
TI Wound management with vacuum-assisted closure: experience in 51
   pediatric patients
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 35th Annual Meeting of the American-Pediatric-Surgical-Association
CY MAY 27-30, 2004
CL Ponte Vedra, FL
SP Amer Pediatr Surg Assoc
DE complex wounds; wound care; negative pressure therapy; vacuum-assisted
   wound care
ID NECROTIZING FASCIITIS; CLINICAL-EXPERIENCE
AB Background/Purpose: Soft tissue loss from infectious, vascular, and traumatic disorders often results in poor healing, painful wound care, and the need for repeated operations. This retrospective study evaluates a single-institutional experience with negative pressure therapy (NPT), using the vacuum-assisted closure (VAC) device in a group of children with diverse soft tissue problems.
   Methods: The medical records of 51 patients treated with NPT from January 2000 to July 2003 were reviewed for demographics, diagnosis, duration of VAC therapy, wound closure, recurrent disease, and complications.
   Results: Patients were classified by diagnosis: group 1: pilonidal disease (n = 21, primary 6 and recurrent = 15); group 2: sacral and extremity ulcers (n = 9); group 3: traumatic soft tissue wounds (n 9); and group 4: extensive tissue loss (n = 12) from the abdominal wall (n = 7), perineum (n = 2), thigh (n = 2), and axilla (n = 1). Group 1 had an average age of 16 years (range, 10-20 years), 67% were obese, and had an average length of follow-up of 13 months (range, 8-36 months). VAC was placed in the operating room in 95% with subsequent outpatient care that included dressing change 3 times weekly. Healing occurred in all patients with primary disease at an average of 37 days. For patients with recurrent disease, 12 healed at an average of 48 days and 3 developed recurrent sinuses. Group 2 was treated with VAC as a bridge to skin grafting or flap closure. All children in group 3 achieved healing without skin grafting at an average of 10 days and with acceptable cosmesis. Negative pressure therapy in group 4 was the only wound treatment in 10 patients and adjunctive to operative closure in 2. Complications from VAC occurred in 5 patients: retained sponge in 2 and device malfunction in 3.
   Conclusions: Negative pressure therapy offers a safe, cost-effective alternative to traditional complex wound care in children. Its advantages are less frequent dressing changes, outpatient management, resumption of daily activities including return to school, and a high degree of patient tolerance. (C) 2005 Elsevier Inc. All rights reserved.
C1 Ohio State Univ, Coll Med & Publ Hlth, Dept Surg, Div Pediat Surg, Columbus, OH 43205 USA.
   Childrens Hosp, Columbus, OH 43205 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; Nationwide Childrens Hospital
RP Caniano, DA (通讯作者)，Ohio State Univ, Coll Med & Publ Hlth, Dept Surg, Div Pediat Surg, Columbus, OH 43205 USA.
EM canianod@chi.osu.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 15
TC 92
Z9 111
U1 0
U2 10
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 0022-3468
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD JAN
PY 2005
VL 40
IS 1
BP 128
EP 132
DI 10.1016/j.jpedsurg.2004.09.016
PG 5
WC Pediatrics; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 896IE
UT WOS:000226927000032
PM 15868572
DA 2026-07-24
ER
PT J
AU Mehbod, AA
   Ogilvie, JW
   Pinto, MR
   Schwender, JD
   Transfeldt, EE
   Wood, KB
   Le Huec, JC
   Dressel, T
AF Mehbod, AA
   Ogilvie, JW
   Pinto, MR
   Schwender, JD
   Transfeldt, EE
   Wood, KB
   Le Huec, JC
   Dressel, T
TI Postoperative deep wound infections in adults after spinal fusion -
   Management with vacuum-assisted wound closure
SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES
LA English
DT Article
DE vacuum-assisted closure; postoperative spine infection; spine; infection
ID INSTRUMENTATION; THERAPY; SALVAGE
AB Objective: Vacuum-assisted wound closure (VAC) exposes the wound bed to negative pressure, resulting in removal of edema fluid, improvement of blood supply, and stimulation of cellular proliferation of reparative granulation tissue. It has been used to treat open wounds in the extremities, open sternal wounds, pressure ulcers, and abdominal wall wounds. This study retrospectively reviewed instrumented spine fusions complicated by surgical wound infection and managed by a protocol including the use of VAC in order to evaluate the efficacy of applying vacuum therapy on patients with deep spine infections and exposed instrumentation.
   Methods: Twenty consecutive patients with deep wound infections after undergoing spinal fusion procedures were studied. There were 12 men and 8 women with an average age of 55 years (31-81 years). Eight patients had undergone concomitant anterior and posterior arthrodesis, nine patients had a posterior spinal fusion, and three patients had a transforaminal lumbar interbody fusion. Seven patients had a decompression with exposed. dura. Sixteen patients presented with a draining wound within the first 6 weeks postoperatively (average 24 days). There were four patients who presented with back pain and temperature after 1 year postoperatively (average 3 years). All patients were taken to the operating room for irrigation and debridement followed by placement of the VAC with subsequent delayed closure of the wound.
   Results: There was an average of 1.8 (1-8) irrigation and debridement procedures prior to placement of the VAC. Once the VAC was initiated, there was an average of 2.2 (2-3) procedures until and including closure of the wound. The wound was closed an average of 7 days (5-14 days) after the placement of the initial VAC in the wound. All patients tolerated the VAC without adverse effects. All patients were kept on a 6-week course of intravenous antibiotic therapy. The average follow-up was 10 months (6-24 months). There were no cases of uncontrolled sepsis once the VAC was initiated. All patients achieved a clean closed wound without removal of instrumentation at a minimum follow-up of 6 months.
   Conclusion: VAC therapy is an effective adjunct in closing complex deep spinal wounds with exposed instrumentation.
C1 Twin Cities Spine Ctr, Minneapolis, MN 55404 USA.
   CHU Bordeaux, Dept Pr Chauveaux, Bordeaux, France.
C3 CHU Bordeaux; Universite de Bordeaux
RP Mehbod, AA (通讯作者)，Twin Cities Spine Ctr, 913 E 26 St,Piper Bldg,Suite 600, Minneapolis, MN 55404 USA.
EM AMehbod@yahoo.com
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NR 18
TC 99
Z9 131
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1536-0652
J9 J SPINAL DISORD TECH
JI J. Spinal Disord. Tech.
PD FEB
PY 2005
VL 18
IS 1
BP 14
EP 17
DI 10.1097/01.bsd.0000133493.32503.d3
PG 4
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 897PC
UT WOS:000227016100003
PM 15687846
DA 2026-07-24
ER
PT J
AU Bernstein, BH
   Tam, H
AF Bernstein, BH
   Tam, H
TI Combination of subatmospheric pressure dressing and gravity feed
   antibiotic instillation in the treatmetn of post-surgical diabetic foot
   wounds: A case series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUCTION IRRIGATION; PMMA-BEADS; THERAPY;
   GENTAMICIN; BONE; SKIN
AB A new negative pressure wound therapy (NPWT) device with solution instillation capability (V.A.C.(R)- Instill(TM), KCI, San Antonio, Tex) will be discussed. Historical delivery methods for local antibiotic levels directly to the post-surgical field are antibiotic-laced beads, Kritter-type instillation catheters, and closed suction irrigation. These devices will be reviewed and contrasted with both traditional NPWT as well as the new NPWT with instillation. The authors present 5 diabetic foot surgical case studies highlighting the use of NPWT with instillation followed by a discussion of the reduced length of stay demonstrated in the case studies. The basis of both moist wound healing and wound irrigation will be discussed. The pros and cons of various topical solution choices will be reviewed. The authors will also present a list of scenarios in which the new NPWT with instillation option should be considered.
C1 Staten Isl Univ Hosp, Diabet Food Team, Staten Isl, NY USA.
   Tidewater Foot & Angkle Res Fdn Fellowship, Virginia Beach, VA USA.
C3 Northwell Health
RP Bernstein, BH (通讯作者)，623 W Union Blvd, Bethlehem, PA 18018 USA.
EM daktari6@netzero.com
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NR 56
TC 36
Z9 53
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2005
VL 17
IS 2
BP 37
EP 48
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 902RM
UT WOS:000227374200005
DA 2026-07-24
ER
PT J
AU Lambert, KV
   Hayes, P
   McCarthy, M
AF Lambert, KV
   Hayes, P
   McCarthy, M
TI Vacuum assisted closure: A review of development and current
   applications
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE vacuum assisted closure; topical negative pressure; vacuum sealing
   technique; sub-atmospheric pressure; dressings; wound management; acute
   wounds; chronic wounds
ID TOPICAL NEGATIVE-PRESSURE; SUBATMOSPHERIC PRESSURE; WOUND CONTROL;
   THERAPY; DEVICE; TRIAL
AB Vacuum assisted closure is being increasingly used for wound management. This review examines the history of its development and appraises the current evidence on its use so far.
C1 Univ Leicester, Vasc Surg Res Grp, Div Cardiovasc Sci, Leicester LE2 7ES, Leics, England.
C3 University of Leicester
RP Lambert, KV (通讯作者)，Univ Leicester, Vasc Surg Res Grp, Div Cardiovasc Sci, Robert Kilpatrick Bldg,Infirm Sq, Leicester LE2 7ES, Leics, England.
EM kellylambert@hotmail.com; paul.hayes@easynet.net.uk; lmcc30@aol.co.uk
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NR 42
TC 126
Z9 157
U1 0
U2 14
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD MAR
PY 2005
VL 29
IS 3
BP 219
EP 226
DI 10.1016/j.ejvs.2004.12.017
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 903KR
UT WOS:000227425200001
PM 15694791
DA 2026-07-24
ER
PT J
AU de Leon, J
AF de Leon, J
TI Negative pressure wound therapy in pressure ulcer management
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article; Proceedings Paper
CT National Vacuum-Assisted Closure Education Conference
CY NOV 05-07, 2004
CL Los Angeles, CA
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   MILLER H, 1994, PUBLICATION US DEP H
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
NR 10
TC 2
Z9 7
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2005
SU S
BP 3S
EP 8S
PG 6
WC Dermatology; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 906AP
UT WOS:000227613200002
DA 2026-07-24
ER
PT J
AU Page, JC
   Newswander, B
   Schwenke, DC
   Hansen, M
   Ferguson, J
AF Page, JC
   Newswander, B
   Schwenke, DC
   Hansen, M
   Ferguson, J
TI Negative pressure wound therapy in open foot wounds with significant
   soft tissue defects
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article; Proceedings Paper
CT National Vacuum-Assisted Closure Education Conference
CY NOV 05-07, 2004
CL Los Angeles, CA
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE;
   RANDOMIZED-TRIAL; RELIABLE METHOD; EXPERIENCE; MANAGEMENT; SYSTEM;
   DEVICE
AB Negative pressure wound therapy (NPWT) has been used regularly since early 2000 by the Podiatry Section at the Carl T. Hayden VA Medical Center (VA), Phoenix, Ariz., for the management of open foot wounds with significant soft tissue defects. Initial impressions of its efficacy were favorable. To confirm or refute these impressions, the podiatry team conducted a retrospective analysis of selected outcomes in patients treated with either NPWT or standard wet-to-moist dressings. The primary outcomes to be assessed were wound cavity filling time and total time to complete closure of the wound. Secondary outcomes considered were other surgical procedures performed on the study foot, complications of the study foot, and number and length of readmissions for subsequent problems in the study foot. All secondary outcomes were assessed during the year following the definitive surgical procedure, which was performed just before initiation of NPWT or wet-to-moist gauze dressing use.
RI Schwenke, Dawn/AEK-1351-2022
OI Schwenke, Dawn/0000-0003-0920-8441
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 33
TC 2
Z9 2
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2005
SU S
BP 9S
EP 14S
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Dermatology; Surgery
GA 906AP
UT WOS:000227613200003
PM 15699558
DA 2026-07-24
ER
PT J
AU Wolvos, T
AF Wolvos, T
TI Wound instillation with negative pressure wound therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article; Proceedings Paper
CT National Vacuum-Assisted Closure Education Conference
CY NOV 05-07, 2004
CL Los Angeles, CA
ID BACITRACIN-IRRIGATION
AB In the following article, some of the antibiotics used have not yet been specifically cleared by the FDA for topical use; accordingly, KCI is not permitted to specifically promote their use. Selection of the appropriate antibiotic for instillation therapy is based on the clinician's experience in his/her practice, including routine manual irrigation. Some of this clinical experience has been published. For the purposes of this publication, the editor (with the permission of the author) has replaced the specific antibiotic name with "an appropriate antibiotic".
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NR 16
TC 6
Z9 13
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2005
SU S
BP 21S
EP 26S
PG 6
WC Dermatology; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 906AP
UT WOS:000227613200005
DA 2026-07-24
ER
PT J
AU Schlatterer, D
   Webb, LX
AF Schlatterer, D
   Webb, LX
TI Orthopedic indications for negative pressure wound therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article; Proceedings Paper
CT National Vacuum-Assisted Closure Education Conference
CY NOV 05-07, 2004
CL Los Angeles, CA
CR Morykwas MJ, 1999, J BURN CARE REHABIL, V20, P15, DOI 10.1097/00004630-199901001-00003
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Webb LX, 2001, UNFALLCHIRURG, V104, P918, DOI 10.1007/PL00002776
NR 3
TC 2
Z9 7
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2005
SU S
BP 27S
EP 28S
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Dermatology; Surgery
GA 906AP
UT WOS:000227613200006
PM 15699561
DA 2026-07-24
ER
PT J
AU Niezgoda, JA
AF Niezgoda, JA
TI Combining negative pressure wound therapy with other wound management
   modalities
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article; Proceedings Paper
CT National Vacuum-Assisted Closure Education Conference
CY NOV 05-07, 2004
CL Los Angeles, CA
ID EXPRESSION
RI /AAV-2360-2021
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   PIERSON T, UNPUB EFFECTS LOW FR
NR 11
TC 3
Z9 8
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2005
SU S
BP 36S
EP 38S
PG 3
WC Dermatology; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 906AP
UT WOS:000227613200008
DA 2026-07-24
ER
PT J
AU Orgill, DP
   Bayer, LR
AF Orgill, DP
   Bayer, LR
TI Advancing the treatment options of chest wounds with negative pressure
   wound therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article; Proceedings Paper
CT National Vacuum-Assisted Closure Education Conference
CY NOV 05-07, 2004
CL Los Angeles, CA
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUNDS; INFECTION; SYSTEM; BRIDGE
RI Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
CR *AM HEART AS, OP HEART SURG STAT
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NR 23
TC 4
Z9 10
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2005
SU S
BP 39S
EP 43S
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Dermatology; Surgery
GA 906AP
UT WOS:000227613200009
PM 15699564
DA 2026-07-24
ER
PT J
AU Niezgoda, JA
   Page, JC
   Kaplan, M
AF Niezgoda, JA
   Page, JC
   Kaplan, M
TI The economic value of negative pressure wound therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article; Proceedings Paper
CT National Vacuum-Assisted Closure Education Conference
CY NOV 05-07, 2004
CL Los Angeles, CA
ID ABDOMINAL COMPARTMENT SYNDROME; FASCIAL CLOSURE
RI /AAV-2360-2021
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NR 16
TC 7
Z9 13
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2005
SU S
BP 44S
EP 47S
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Dermatology; Surgery
GA 906AP
UT WOS:000227613200010
PM 15699565
DA 2026-07-24
ER
PT J
AU Lam, WL
   Garrido, A
   Stanley, PRW
AF Lam, WL
   Garrido, A
   Stanley, PRW
TI Use of topical negative pressure in the treatment of chronic
   osteomyelitis - A case report
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY; WOUND CONTROL; MUSCLE FLAPS
C1 Castle Hill Hosp, Hull & E Yorkshire NHS Trust, Dept Plast & Reconstruct Surg, Cottingham HU16 5JQ, Yorks, England.
C3 University of Hull
RP Lam, WL (通讯作者)，1 Springfield Terrace, Leeds LS17 8NU, W Yorkshire, England.
EM weeleon@yahoo.com
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NR 12
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD MAR
PY 2005
VL 87A
IS 3
BP 622
EP 624
DI 10.2106/JBJS.C.01743
PG 3
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 906CD
UT WOS:000227617200022
PM 15741632
DA 2026-07-24
ER
PT J
AU Kopp, J
   Strnad, V
   Bach, AD
   Sauer, R
   Horch, RE
AF Kopp, J
   Strnad, V
   Bach, AD
   Sauer, R
   Horch, RE
TI Vacuum application increases therapeutic safety and allows intensified
   local radiation treatment of malignant soft-tissue tumors
SO STRAHLENTHERAPIE UND ONKOLOGIE
LA English
DT Article
DE brachytherapy; vacuum-assisted closure; tissue preconditioning; flap
   surgery
ID INTRAOPERATIVE RADIOTHERAPY; ASSISTED CLOSURE; BREAST-CANCER; WOUND
   CONTROL; BRACHYTHERAPY; SARCOMAS; BOOST; EXPERIENCE; CARCINOMA; IORT
AB Purpose: In order to simplify and improve outcome of radiation therapy and final defect coverage in patients suffering from invasive soft-tissue tumors, brachytherapy and application of V.A.C.uum-assisted closure (V.A.C.(R)) were combined with delaying flap incision. Patients and
   Methods: Two patients were excised as radically as possible and brachytherapy tubes were implanted directly on the tumor bed. At the same time, flaps for Later defect coverage were preconditioned by circumcision. Brachytherapy and external-beam irradiation were performed directly on the vacuum sponge followed by subsequent defect coverage with the preconditioned flaps.
   Results: Excision significantly reduced tumor masses in both patients; in one case sensible and motor function of the involved extremity was clearly improved. V.A.C.(R) coverage allowed repeated brachytherapy and external-beam applications following exact placing of plastic tubes and FLABs on the tumor bed. Sequential irradiation had no effect on neighboring flap tissues, which healed without impairment following transposition.
   Conclusion: Combination of V.A.C.(R) and brachytherapy can effectively replace circumstantial and Laborious IORT (intraoperative radiotherapy) procedures. Exact placement of tubes on the tumor bed without subsequent tissue coverage is conserving preconditioned flap tissues, which are transposed for final defect coverage at the end of radiotherapy. However, by circumventing radiation exposure of these tissues, a possible later irradiation sequence can be performed without endangering defect-covering flaps.
C1 Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
   Univ Erlangen Nurnberg, Med Ctr, Dept Radiat Therapy, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM Raymund.Horch@chir.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
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U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0179-7158
EI 1439-099X
J9 STRAHLENTHER ONKOL
JI Strahlenther. Onkol.
PD FEB
PY 2005
VL 181
IS 2
BP 124
EP 130
DI 10.1007/s00066-005-1291-0
PG 7
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 908GQ
UT WOS:000227775900008
PM 15702301
DA 2026-07-24
ER
PT J
AU Geller, SM
   Longton, JA
AF Geller, SM
   Longton, JA
TI Ulceration of pyoderma gangrenosum treated with negative pressure wound
   therapy
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Pyoderma gangrenosum is a skin disease characterized by wounds with blue-to-purple undermined borders surrounding purulent necrotic bases. This article reports on a patient with a circumferential, full-thickness, and partially necrotic lower-extremity ulceration of unknown etiology. Results of laboratory tests and arterial and venous imaging studies were found to be within normal limits. The diagnosis of pyoderma gangrenosum was made on the basis of the histologic appearance of the wound tissue after biopsy as a diagnosis of exclusion. Negative pressure wound therapy was undertaken, which saved the patient's leg from amputation. Although negative pressure wound therapy has demonstrated efficacy in the treatment of chronic wounds in a variety of circumstances, this is the first documented use of this technique to treat an ulceration secondary to pyoderma gangrenosum.
C1 Phoenix Baptist Hosp, Podiatry Program, Phoenix, AZ 85021 USA.
RP Geller, SM (通讯作者)，Phoenix Baptist Hosp, Podiatry Program, 1728 W Glendale,Ste 103, Phoenix, AZ 85021 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 13
TC 10
Z9 16
U1 0
U2 0
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD MAR-APR
PY 2005
VL 95
IS 2
BP 171
EP 174
DI 10.7547/0950171
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 910LQ
UT WOS:000227933300012
PM 15778477
DA 2026-07-24
ER
PT J
AU O'Connor, J
   Kells, A
   Henry, S
   Scalea, T
AF O'Connor, J
   Kells, A
   Henry, S
   Scalea, T
TI Vacuum-assisted closure for the treatment of complex chest wounds
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID INFECTIONS
AB Background. Destruction of chest wall musculature from trauma, empyema, or local infection limits closure options, especially with muscle flaps. While the vacuum-assisted closure system (VAC; KCI International, San Antonio, TX) has been used for wounds in other anatomic locations, we have found no series for chest wounds.
   Methods. This is a retrospective review of trauma registry data from the R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine from 2000 to 2003.
   Results. Seventeen patients were identified and divided into two groups. Group I consisted of seven patients with primary chest wall processes: four necrotizing soft-tissue infections and three with thoracic trauma resulting in significant loss of chest wall musculature. Group II consisted of ten patients with empyema and varying levels of chest wall extension. Six were postpneumonic and four postoperative. Wound size averaged 16 x 7 cm (range, 7 x 3 cm to 21 x 11 cm). The VAC duration averaged nine days (range, 3 to 21 days) and changed every two to three days. Fourteen wounds were culture positive; nine staphylococcus aureus, two alpha hemolytic streptococcus, and one each with enterococcus, Citrobacter, and anaerobes. Eight were polymicrobial. There were no deaths. All wounds healed without rotational muscle flaps. Ten underwent delayed primary closure, four split-thickness skin graft, and three healed by secondary intention. There was one significant complication: a wound infection after delayed primary closure which required reoperation.
   Conclusions. Closure of complex chest wall wounds can present significant technical challenges. The VAC system is a simple, useful, and novel alternative to conventional wound care even with large, infected wounds. (c) 2005 by The Society of Thoracic Surgeons.
C1 Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Dept Thorac & Vasc Surg, Baltimore, MD 21201 USA.
   Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Dept Surg & Crit Care, Baltimore, MD 21201 USA.
   Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Dept Wound Healing & Metab, Baltimore, MD 21201 USA.
   Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Program Trauma, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore
RP O'Connor, J (通讯作者)，Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Dept Thorac & Vasc Surg, 22 S Greene St, Baltimore, MD 21201 USA.
EM joconnor@umm.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Arnold PG, 1996, PLAST RECONSTR SURG, V98, P804, DOI 10.1097/00006534-199610000-00008
   Brown KM, 2001, ANN THORAC SURG, V72, P1409, DOI 10.1016/S0003-4975(01)02844-2
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
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   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
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   Urschel JD, 1997, ANN THORAC SURG, V64, P276, DOI 10.1016/S0003-4975(97)00514-6
NR 9
TC 48
Z9 74
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD APR
PY 2005
VL 79
IS 4
BP 1196
EP 1200
DI 10.1016/j.athoracsur.2004.09.041
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 912PH
UT WOS:000228091100017
PM 15797049
OA Bronze
DA 2026-07-24
ER
PT J
AU Whelan, C
   Stewart, J
   Schwartz, BF
AF Whelan, C
   Stewart, J
   Schwartz, BF
TI Mechanics of wound healing and importance of Vacuum Assisted
   Closure® in urology
SO JOURNAL OF UROLOGY
LA English
DT Review
DE wounds and injuries; vacuum; wound healing; urogenital system; treatment
   outcome
ID FIBROBLAST-GROWTH-FACTOR; RANDOMIZED-TRIAL; FACTOR-BB; COLLAGEN; MATRIX;
   SKIN; KERATINOCYTES; FIBRONECTIN; MACROPHAGES; EXPRESSION
AB Purpose: We discuss the mechanisms of wound healing and our experience with the Vacuum Assisted Closure device (Kinetic Concepts, Inc., San Antonio, Texas) for complex urogenital wounds.
   Materials and Methods: The literature obtained from a Medline search on wound healing, wound failure and vacuum assisted closure was reviewed. In addition, we reviewed our experience with negative pressure wound therapy.
   Results: Wound healing is a complex interaction between the reticuloendothelial and immune systems, in addition to correctable internal and external factors. Understanding the healing process improves outcomes and decreases patient morbidity. Negative pressure wound therapy has hastened wound healing and it adds significant improvement in the arsenal of choices available.
   Conclusions: Vacuum Assisted Closure (R) is a therapeutic alternative that complements surgical and medical intervention in patients with complex wounds.
C1 So Illinois Univ, Sch Med, Ctr Laparoscopy & Endourol, Div Urol, Springfield, IL 62794 USA.
C3 Southern Illinois University System; Southern Illinois University
RP Schwartz, BF (通讯作者)，So Illinois Univ, Sch Med, Ctr Laparoscopy & Endourol, Div Urol, POB 19665, Springfield, IL 62794 USA.
EM bschwartz@siumed.edu
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NR 63
TC 33
Z9 48
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5347
EI 1527-3792
J9 J UROLOGY
JI J. Urol.
PD MAY
PY 2005
VL 173
IS 5
BP 1463
EP 1470
DI 10.1097/01.ju.0000157339.05939.21
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 918RC
UT WOS:000228564300006
PM 15821461
DA 2026-07-24
ER
PT J
AU Wackenfors, A
   Gustafsson, R
   Sjögren, J
   Algotsson, L
   Ingemansson, R
   Malmsjö, M
AF Wackenfors, A
   Gustafsson, R
   Sjögren, J
   Algotsson, L
   Ingemansson, R
   Malmsjö, M
TI Blood flow responses in the peristernal thoracic wall during
   vacuum-assisted closure therapy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID STERNAL WOUND-INFECTION; TISSUE OXYGEN-TENSION; POSTSTERNOTOMY
   MEDIASTINITIS; POSTOPERATIVE-PATIENTS; MACROPHAGES; PERFUSION; DEEP;
   ANGIOGENESIS; EXPERIENCE; LACTATE
AB Background. Vacuum-assisted closure (VAC) therapy is a recently introduced method for the treatment of poststernotomy mediastinitis. The aim of this study was to examine the effects of negative pressure on peristernal soft tissue blood flow and metabolism because the mechanisms by which vacuum-assisted closure therapy promotes wound healing are not known in detail.
   Methods. Microvascular blood flow was examined by laser Doppler velocimetry in an uninfected porcine sternotomy wound model. Microvascular blood flow was examined in the muscular and subcutaneous tissue, at different distances from the wound edge, after the application of -50 to -200 mm Hg. Wound fluid pH, partial pressures of oxygen and carbon dioxide, bicarbonate, and lactate were analyzed after 0, 30, and 60 minutes of continuous negative pressure.
   Results. Vacuum-assisted closure therapy induced an increase in the microvascular blood flow a few centimeters from the wound edge. In muscular tissue, the distance from the wound edge to the position at which the blood flow was increased was shorter than that in subcutaneous tissue. Close to the wound edge, relative hypoperfusion was observed. The hypoperfused zone was larger at high negative pressures and was especially prominent in subcutaneous tissue. Wound fluid partial pressure of oxygen and lactate levels were increased after 60 minutes of vacuum-assisted closure therapy, which may be the result of changes in the microvascular blood flow.
   Conclusions. Vacuum-assisted closure therapy induces a change in microvascular blood flow that is dependent on the pressure applied, the distance from the wound edge, and the tissue type. It may be beneficial to tailor the negative pressure used for vacuum-assisted closure therapy according to the wound tissue composition. Wound fluid partial pressure of oxygen and lactate levels increased during vacuum-assisted closure therapy. This combination is known to promote wound healing. © 2005 by The Society of Thoracic Surgeons.
C1 Univ Lund Hosp, Dept Internal Med, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Anesthesia, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Wackenfors, A (通讯作者)，BMC, Expt Vasc Res, BMC A13, SE-22184 Lund, Sweden.
EM angelica.wackenfors@med.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599; 
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NR 29
TC 184
Z9 210
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD MAY
PY 2005
VL 79
IS 5
BP 1724
EP 1731
DI 10.1016/j.athoracsur.2004.10.053
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 922YR
UT WOS:000228876300041
PM 15854963
DA 2026-07-24
ER
PT J
AU Nugent, N
   Lannon, D
   O'Donnell, M
AF Nugent, N
   Lannon, D
   O'Donnell, M
TI Vacuum-assisted closure - a management option for the burns patient with
   exposed bone
SO BURNS
LA English
DT Article
ID SECURING SKIN-GRAFTS; WOUNDS; EXPERIENCE; SYSTEM
C1 St James Hosp, Burns Unit, Dublin 8, Ireland.
C3 Trinity College Dublin
RP Nugent, N (通讯作者)，Cork Univ Hosp, Dept Plast Surg, Cork, Ireland.
EM nnugent@vodafone.ie
RI Nugent, Nora/X-4235-2019
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NR 13
TC 20
Z9 31
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAY
PY 2005
VL 31
IS 3
BP 390
EP 393
DI 10.1016/j.burns.2004.10.019
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 926YE
UT WOS:000229158800026
PM 15774302
DA 2026-07-24
ER
PT J
AU Lee, SS
   Lin, SD
   Chen, HM
   Lin, TM
   Yang, CC
   Lai, CS
   Chen, YF
   Chiu, CC
AF Lee, SS
   Lin, SD
   Chen, HM
   Lin, TM
   Yang, CC
   Lai, CS
   Chen, YF
   Chiu, CC
TI Management of intractable sternal wound infections with topical negative
   pressure dressing
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Plastic-Surgical-Association-Taiwan
CY DEC 21, 2002
CL Taipei, TAIWAN
SP Plast Surg Assoc Taiwan
ID VACUUM-ASSISTED CLOSURE; HEART-SURGERY; MUSCLE FLAP; MEDIASTINITIS;
   OMENTUM
AB Background: Sternal osteomyelitis after cardiac surgery is a life-threatening complication. The potential spread of infection into the mediastinum, involving the prosthetic valve, grafts, and suture lines, makes this an extremely serious complication confronting both cardiac and plastic surgeons. Aim: Topical negative pressure (TNP) dressing has been proven to be effective for wound healing. We want to take advantages of this equipment to improve the results of intractable sternal wound infection. The results are discussed. Methods: From December 1996 to July 2002, 25 patients with sternal wound infections were treated at Kaohsiung Medical University Hospital. Nine patients suffering intractable sternal osteomyelitis were managed with debridement and TNP dressings. These patients received 1-3 debridements (an average of 2.2 debridements), and the average TNP dressing treatment period was 20.2 days (ranging from 3 to 43 days). After management, the infections were controlled and healthy vascularized wounds were achieved. Then, flap reconstruction could be performed for complete wound closure. Seven of the nine patients survived, and there was no recurrence of sternal osteomyelitis during follow-up period (ranging from 5 to 70 months). Conclusion: The advantages of applying TNP dressings in cases of intractable sternal wound infections include (1) protecting the underlying mediasternal structure from infection, (2) permitting delayed sternal closure to avoid cardiac compression induced compromised cardiopulmonary function, (3) possibility of repeated wound inspection and bedside debridement, (4) cost-effectiveness of wound care, and (5) providing an option to promote sternal wound secondary healing for patients in poor physical condition.
C1 Kaohsiung Med Univ, Chung Ho Mem Hosp, Div Plast & Reconstruct Surg, Kaohsiung 807, Taiwan.
   Kaohsiung Med Univ, Chung Ho Mem Hosp, Div Cardiovasc Surg, Dept Surg, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital
RP Lee, SS (通讯作者)，Kaohsiung Med Univ, Chung Ho Mem Hosp, Div Plast & Reconstruct Surg, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan.
EM sushin@kmu.edu.tw
RI Chen, Huai-Min/D-4860-2009; Chen, Ying-Fu/D-1197-2009; /D-5171-2009;
   Lai, Chung Sheng/C-7448-2009; lin, sindaw/D-5504-2009; Lee,
   Su-Shin/D-4722-2009
OI Lai, Chung Sheng/0000-0002-1298-9325; lin, sindaw/0000-0002-2269-8484; 
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NR 28
TC 7
Z9 14
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD MAY-JUN
PY 2005
VL 20
IS 3
BP 218
EP 222
DI 10.1111/j.1540-8191.2005.200416.x
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Surgery
GA 930GB
UT WOS:000229402700004
PM 15854081
DA 2026-07-24
ER
PT J
AU Sjögren, J
   Gustafsson, R
   Nilsson, J
   Malmsjö, M
   Ingemansson, R
AF Sjögren, J
   Gustafsson, R
   Nilsson, J
   Malmsjö, M
   Ingemansson, R
TI Clinical outcome after poststernotomy mediastinitis: Vacuum-assisted
   closure versus conventional treatment
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID STERNAL WOUND-INFECTION; POSTOPERATIVE MEDIASTINITIS; FLAP
   RECONSTRUCTION; SUCTION DRAINAGE; MUSCLE FLAPS; RISK-FACTORS;
   STERNOTOMY; MANAGEMENT; SURGERY; IRRIGATION
AB Background. The conventional treatment for poststernotomy mediastinitis usually involves surgical revision, closed irrigation, or reconstruction with omentum or pectoral muscle flaps. Recently, vacuum-assisted closure has been successfully used in poststernotomy mediastinitis. The aim of the present study was to compare the clinical outcome and survival in 101 patients undergoing vacuum-assisted closure therapy or conventional treatment for poststernotomy mediastinitis.
   Methods. One hundred one consecutive patients underwent treatment for poststernotomy mediastinitis: vacuum-assisted closure therapy (January 1999 through December 2003, n = 61) or conventional treatment (July 1994 through December 1998, n = 40). Follow-up was made in April 2004 and was 100% complete. Actuarial statistics were used to calculate the survival rates.
   Results. The 90-days mortality was 0% in the vacuum-assisted closure group and 15% in the conventional treatment group (p < 0.01). The failure rate to first-line treatment with vacuum-assisted closure and conventional treatment were 0% and 37.5%, respectively (p < 0.001). There was no statistically significant difference in the recurrence of sternal fistulas after vacuum-assisted closure therapy or conventional treatment: 6.6% versus 5.0%, respectively. Overall survival in the vacuum-assisted closure group was significantly better (p < 0.05) than in the conventional treatment group: 97% versus 84% (6 months), 93% versus 82% (1 year), and 83% versus 59% (5 years).
   Conclusions. Our findings support that vacuum-assisted closure therapy is a safe and reliable option in poststernotomy mediastinitis with excellent survival and a very low failure rate compared with conventional treatment. (c) 2005 by The Society of Thoracic Surgeons.
C1 Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Internal Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Sjögren, J (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM johan.sjogren@thorax.lu.se
RI Sjögren, Johan/AAZ-6448-2021; Nilsson, Johan/A-4742-2011
OI Nilsson, Johan/0000-0001-6860-6090; Ingemansson,
   Richard/0000-0001-7623-8953; Maljö, Malin/0000-0001-9849-9599
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NR 34
TC 158
Z9 176
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD JUN
PY 2005
VL 79
IS 6
BP 2049
EP 2055
DI 10.1016/j.athoracsur.2004.12.048
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 931YJ
UT WOS:000229521100036
PM 15919308
DA 2026-07-24
ER
PT J
AU Jones, SM
   Banwell, PE
   Shakespeare, PG
AF Jones, SM
   Banwell, PE
   Shakespeare, PG
TI Advances in wound healing: topical negative pressure therapy
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; STRESS; TRIAL; SWINE;
   SKIN
AB In clinical practice many wounds are slow to heal and difficult to manage. The recently introduced technique of topical negative pressure therapy (TNP) has been developed to try to overcome some of these difficulties. TNP applies a controlled negative pressure to the surface of a wound that has potential advantages for wound treatment and management. Although the concept itself, of using suction in wound management is not new, the technique of applying a negative pressure at the surface of the wound is. This paper explores the origins and proposed mechanisms of action of TNP therapy and discusses the types of wounds that are thought to benefit most from use of this system.
C1 Salisbury Dist Hosp, Laing Lab, Odstock Burns & Wound Healing Charitable Trust, Salisbury SP2 8BJ, Wilts, England.
C3 Salisbury District Hospital
RP Jones, SM (通讯作者)，Salisbury Dist Hosp, Laing Lab, Odstock Burns & Wound Healing Charitable Trust, Salisbury SP2 8BJ, Wilts, England.
EM Sophie.Jones@nhs.net
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NR 29
TC 54
Z9 72
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0032-5473
EI 1469-0756
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD JUN
PY 2005
VL 81
IS 956
BP 353
EP 357
DI 10.1136/pgmj.2004.026351
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 932UR
UT WOS:000229580000002
PM 15937199
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Dainty, LA
   Bosco, JJ
   McBroom, JW
   Winter, WE III
   Rose, GS
   Elkas, JC
AF Dainty, LA
   Bosco, JJ
   McBroom, JW
   Winter, WE III
   Rose, GS
   Elkas, JC
TI Novel techniques to improve split-thickness skin graft viability during
   vulvo-vaginal reconstruction
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
DE fibrin tissue adhesives; split-thickness skin grafts; vulvo-vaginal
   reconstruction; wound vacuum-assisted closure device
ID VACUUM-ASSISTED CLOSURE; FIBRIN GLUE; WOUND FAILURES
AB Background. Split-thickness skin grafts are often utilized for vulvo-vaginal reconstruction. Unfortunately, infection and sloughing may occur in up to 22% of patients with standard techniques especially at irradiated recipient sites.
   Cases. We report seven cases of vulvo-vaginal reconstruction using split-thickness skin grafts. In this series, we used fibrin tissue adhesives with and without vacuum-assisted closure devices to augment graft adherence and viability. We briefly describe the clinical history, surgical techniques, and outcomes of the cohort.
   Conclusion. Fibrin tissue adhesives and wound vacuum-assisted closure devices may improve the viability of split-thickness skin grafts during vulvo-vaginal reconstruction. Published by Elsevier Inc.
C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA.
   Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Honolulu, HI 96859 USA.
   Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA.
C3 Walter Reed National Military Medical Center; United States Department
   of Defense; United States Army; United States Department of Defense;
   United States Army; Tripler Army Medical Center; Brooke Army Medical
   Center; United States Department of Defense; United States Army
RP Elkas, JC (通讯作者)，Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM john.elkas@na.amedd.army.mil
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NR 17
TC 20
Z9 26
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
EI 1095-6859
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD JUN
PY 2005
VL 97
IS 3
BP 949
EP 952
DI 10.1016/j.ygyno.2005.03.021
PG 4
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA 937TJ
UT WOS:000229948200037
PM 15896830
DA 2026-07-24
ER
PT J
AU Venturi, ML
   Attinger, CE
   Mesbahi, AN
   Hess, CL
   Graw, KS
AF Venturi, ML
   Attinger, CE
   Mesbahi, AN
   Hess, CL
   Graw, KS
TI Mechanisms and clinical applications of the vacuum-assisted closure
   (VAC) device - A review
SO AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
LA English
DT Review
ID SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE; NEGATIVE-PRESSURE;
   RANDOMIZED-TRIAL; WOUND CONTROL; THERAPY; MANAGEMENT; SOFT
AB The use of sub-atmospheric pressure dressings, available commercially as the vacuum-assisted closure (VAC) device, has been shown to be an effective way to accelerate healing of various wounds. The optimal sub-atmospheric pressure for wound healing appears to be approximately 125mm Hg utilizing an alternating pressure cycle of 5 minutes of suction followed by 2 minutes off suction. Animal studies have demonstrated that this technique optimizes blood flow, decreases local tissue edema, and removes excessive fluid from the wound bed. These physiologic changes facilitate the removal of bacteria from the wound. Additionally, the cyclical application of sub-atmospheric pressure alters the cytoskeleton of the cells in the wound bed, triggering a cascade of intracellular signals that increases the rate of cell division and subsequent formation of granulation tissue. The combination of these mechanisms makes the VAC device an extremely versatile tool in the armamentarium of wound healing. This is evident in the VAC device's wide range of clinical applications, including treatment of infected surgical wounds, traumatic wounds, pressure ulcers, wounds with exposed bone and hardware, diabetic foot ulcers, and venous stasis ulcers. VAC has also proven useful in reconstruction of wounds by allowing elective planning of the definitive reconstructive surgery without jeopardizing the wound or outcome. Furthermore, VAC has significantly increased the skin graft success rate when used as a bolster over the freshly skin-grafted wound. VAC is generally well tolerated and, with few contraindications or complications, is fast becoming a mainstay of current wound care.
C1 Georgetown Univ Hosp, Limb Ctr, Washington, DC 20007 USA.
C3 Georgetown University
RP Attinger, CE (通讯作者)，Georgetown Univ Hosp, Limb Ctr, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM cattinger@aol.com
CR [Anonymous], 2004, WOUNDS, p3S
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NR 41
TC 268
Z9 397
U1 0
U2 57
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-0561
EI 1179-1888
J9 AM J CLIN DERMATOL
JI Am. J. Clin. Dermatol.
PY 2005
VL 6
IS 3
BP 185
EP 194
DI 10.2165/00128071-200506030-00005
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 939AK
UT WOS:000230044300005
PM 15943495
DA 2026-07-24
ER
PT J
AU Dobke, MK
   Nguyen, D
   Trott, SA
AF Dobke, MK
   Nguyen, D
   Trott, SA
TI A novel approach to acute infection of the glenohumeral joint following
   rotator cuff repair - A case series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
AB Glenohumeral joint infection (GJI) is a difficult-to-treat complication following rotator cuff repair (RCR). The authors present a case series illustrating the management of GJI with debridement, drainage, and simultaneous joint sealing with negative pressure wound therapy (NPWT, V.A.C.(R) Therapy (TM) System, KCl, San Antonio, Tex) followed by muscle flap coverage. Six patients with acute Staphylococcus aureus infection and spontaneous purulent drainage following arthroscopic RCR for post-traumatic problems were treated. Patients underwent serial pulse-lavage debridements through a deltoid-sparing incision followed by NPWT. Closed-system drainage obviated the need for dressing the wound with exposed joint. Grain stain and culture were negative upon second exploration. Within 2 weeks, the joint was covered with a muscle flap. Use of NPWT allowed relatively quick resolution of infection without secondary joint damage due to superinfection or desiccation. Reconstruction of the soft tissue over the joint with a muscle flap resulted in durable coverage without fistula formation or unstable scars.
C1 Univ Calif San Diego, Dept Surg, Div Plast Surg, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego
RP Dobke, MK (通讯作者)，Univ Calif San Diego, Dept Surg, Div Plast Surg, 200 W Arbor Dr, San Diego, CA 92103 USA.
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   Herrera MF, 2002, J SHOULDER ELB SURG, V11, P605, DOI 10.1067/mse.2002.127302
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   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
NR 9
TC 3
Z9 3
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2005
VL 17
IS 6
BP 137
EP 140
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 939FH
UT WOS:000230057300002
DA 2026-07-24
ER
PT J
AU Sarsam, SE
   Elliott, JP
   Lam, GK
AF Sarsam, SE
   Elliott, JP
   Lam, GK
TI Management of wound complications from cesarean delivery
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SURGICAL-SITE INFECTIONS; SUBCUTANEOUS TISSUE;
   SUBATMOSPHERIC PRESSURE; PSYCHOLOGICAL STRESS; GLUCOSE CONTROL;
   RISK-FACTORS; OBESE WOMEN; TRIAL; THICKNESS
AB Multiple factors account for the increasing number of cesarean delivery wound complications in the United States; among them are an increase in cesarean delivery and an increase in the number of overweight and obese patients. This article reviews the pathophysiology of acute wound healing. Risk factors for cesarean delivery wound complications are identified and described. Clinical practices that can reduce the risk of developing wound complications, including Centers for Disease Control and Prevention guidelines, are considered. Treatment guidelines to accelerate wound healing such as secondary closure and negative pressure wound therapy in disrupted wounds are proposed. Older guidelines for management of wounds using secondary intention are critiqued. Historical methods of wound care such as the practice of using certain cleansers and the practice of wet to dry dressings are outdated. Modern wound healing products are described.
   Target Audience: Obstetricians & Gynecologists, Family Physicians
   Learning Objectives: After completion of this article, the reader should be able to describe the effects of obesity on cesarean delivery wound healing, to improve methods of wound healing in the obese patient, and to explain why wet to dry dressing changes are not effective wound management.
C1 Obstet Med Grp Phoenix, Phoenix Perinatal Associates, Phoenix, AZ 85006 USA.
   Univ Arizona, Sch Med, Tucson, AZ USA.
C3 Phoenix Perinatal Associates (PPA); University of Arizona
RP Lam, GK (通讯作者)，Obstet Med Grp Phoenix, Phoenix Perinatal Associates, PC,1331 N 7th St,Suite 275, Phoenix, AZ 85006 USA.
EM Garrett_Lam@obstetrix.com
RI Lam, Garrett/W-9556-2019
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NR 65
TC 34
Z9 48
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD JUL
PY 2005
VL 60
IS 7
BP 462
EP 473
DI 10.1097/01.ogx.0000166603.43959.aa
PG 12
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 943KP
UT WOS:000230352700005
PM 15995563
DA 2026-07-24
ER
PT J
AU Riccio, M
   Pangrazi, PP
   Campodonico, A
   Bertani, A
AF Riccio, M
   Pangrazi, PP
   Campodonico, A
   Bertani, A
TI Delayed microsurgical reconstruction of the extremities for complex
   soft-tissue injuries
SO MICROSURGERY
LA English
DT Article
ID PERIPHERAL VASCULAR-DISEASE; DIABETIC NEUROPATHIC FOOT; HYPERBARIC
   OXYGEN; LIMB SALVAGE; MANAGEMENT; TRANSPLANTATION; OSTEOMYELITIS;
   FRACTURES; FLEXION; TRAUMA
AB The treatment of severe wounds of the extremities, characterized by large posttraumatic tissue loss, represents a clinical problem difficult to resolve, especially when the lesion is surrounded by large areas of ischemic distrophic tissue which progressively aggravate and extend the initial lesion, with frequent exposure of bone and joint structures making the amputation of the limb an inevitable outcome. The authors present their experience based on combined treatments by medical support methods such as hyperbaric oxygen (HBO) and vacuum-assisted closure therapy (VAC) and microsurgical reconstruction of the limbs, within a precise therapeutic protocol. The use of this protocol in appropriate times and ways allowed us to successfully treat severe posttraumatic sequelae of the limbs, avoiding the delayed healing typical of these pathologies, both on the donor site of the flap and on the repaired area, and avoiding unsuitable microsurgical reconstruction of limbs, allowing satisfactory morpho-functional restoration and a reduction of the hospitalization period. (c) 2005 Wiley-Liss, Inc.
C1 Univ Politecn Marche, Clin Chirurg Plast & Ricostrutt, Azienda Osped, I-60020 Ancona, Italy.
   Univ Ancona, Sch Med, Hand Surg & Microsurg Unit, Dept Plast & Reconstruct Surg,Ancona Teaching Hos, Ancona, Italy.
C3 Marche Polytechnic University; Marche Polytechnic University
RP Riccio, M (通讯作者)，Univ Politecn Marche, Clin Chirurg Plast & Ricostrutt, Azienda Osped, Via Conca 71,Azienda Osped Osped Riuniti Umberto, I-60020 Ancona, Italy.
EM michriccio@libero.it
RI ; Riccio, Michele/ABD-2515-2020
OI Campodonico, Anea/0000-0003-1234-978X; Riccio,
   Michele/0000-0001-5554-4759
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NR 38
TC 13
Z9 18
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PY 2005
VL 25
IS 4
BP 272
EP 283
DI 10.1002/micr.20132
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 945LQ
UT WOS:000230504400005
PM 15934116
DA 2026-07-24
ER
PT J
AU Huljev, D
   Kucisec-Tepes, N
AF Huljev, D
   Kucisec-Tepes, N
TI Necrotizing fasciitis of the abdominal wall as a post-surgical
   complication: A case report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID SOFT-TISSUE INFECTIONS; VACUUM-ASSISTED CLOSURE; HYPERBARIC-OXYGEN
   THERAPY; EARLY RECOGNITION; ANAEROBIC COCCI; WOUND CONTROL; MORTALITY;
   CELLULITIS; MICROBIOLOGY; DETERMINANTS
AB Necrotizing fasciitis is an acute surgical condition that demands a prompt and combined treatment. Early recognition, aggressive surgical debridement, and targeted antibiotic therapy significantly affect the overall course of treatment and, ultimately, survival. The authors present a case of a woman with necrotizing fasciitis of the abdominal wall and the course and methods of treatment with particular attention to the microbiological aspect and the use of negative pressure wound therapy as an auxiliary method of closure.
C1 Univ Zagreb, Sveti Duh Gen Hosp, Dept Plast & Reconstruct Surg, Surg Clin, HR-10002 Zagreb, Croatia.
   Univ Zagreb, Sveti Duh Gen Hosp, Dept Clin Microbiol & Hosp Infect, HR-10002 Zagreb, Croatia.
C3 University of Zagreb; University of Zagreb
RP Huljev, D (通讯作者)，Univ Zagreb, Sveti Duh Gen Hosp, Dept Plast & Reconstruct Surg, Surg Clin, Sveti Duh 64, HR-10002 Zagreb, Croatia.
EM dubravko.huliev@zg.t-com.hr
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NR 52
TC 4
Z9 14
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2005
VL 17
IS 7
BP 169
EP 177
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 948ZH
UT WOS:000230753800003
DA 2026-07-24
ER
PT J
AU Datiashvili, RO
   Knox, KR
AF Datiashvili, RO
   Knox, KR
TI Negative pressure dressings: An alternative to free tissue transfers?
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY; SUBATMOSPHERIC PRESSURE; FREE
   FLAPS; THERAPY; EXPERIENCE; WOUNDS; FATE
AB Free tissue transfer is a well established tool for the reconstruction of large, complicated wounds of the extremities. However, when free flap reconstruction is contraindicated or in cases where it has failed, the management of this type of wound presents a formidable task. Although negative pressure wound therapy (NPWT) plays an increasing role in the treatment of complex open wounds, there are only a few reports of successful management of wounds with areas of exposed tendon or bone. The authors present their experience with the use of NPWT in, the treatment of open wounds of the extremities with relatively large areas of exposed bone.
C1 Univ Med & Dent New Jersey, Div Plast Surg, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Datiashvili, RO (通讯作者)，Univ Med & Dent New Jersey, Div Plast Surg, 90 Bergen St,Suite 7200, Newark, NJ 07103 USA.
EM datiasro@umdnj.edu
CR ARCHDEACON MT, 2001, TECHNIQUES ORTHOPAED, V16, P398
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NR 16
TC 7
Z9 12
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2005
VL 17
IS 8
BP 206
EP 212
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 960HJ
UT WOS:000231580900005
DA 2026-07-24
ER
PT J
AU Pattison, PS
   Gordon, JK
   Muto, PM
   Mallen, JK
   Hoerner, J
AF Pattison, PS
   Gordon, JK
   Muto, PM
   Mallen, JK
   Hoerner, J
TI Case report: Using. dual therapies - Negative pressure wound therapy and
   modified silicone gel liner - to treat a limb postamputation and
   dehiscence
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MATRIX; ULCERS
AB Orthopedic trauma wounds with extensive soft tissue damage can be costly and time consuming to heal. This case report illustrates a positive outcome using negative pressure wound therapy in tandem with a silicone gel liner to treat a nonhealing, dehisced incision following a below-the-knee, amputation. The primary goal of using the 2 therapies together was to close the wound while actively reshaping and shrinking the residual limb for a prosthesis. The simultaneous use of these therapies resulted in quicker limb maturation and a reduction in the time for prosthetic fitting compared to the previous standard of care at the authors' institution.
C1 Caritas Holy Family Hosp & Med Ctr, Wound Clin, Methuen, MA 01844 USA.
   Next Step Orthot & Prosthet, N Andover, MA USA.
RP Pattison, PS (通讯作者)，Caritas Holy Family Hosp & Med Ctr, Wound Clin, 70 East St, Methuen, MA 01844 USA.
EM paula.pattison@caritaschristi.org
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Ballard K, 2001, Br J Nurs, V10, pS6
   Banwell P E, 2003, J Wound Care, V12, P22
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   Demling RH, 2004, WOUNDS, V16, P18
   Drosou A, 2003, WOUNDS, V15, P149
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NR 27
TC 3
Z9 3
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2005
VL 17
IS 8
BP 233
EP 240
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 960HJ
UT WOS:000231580900008
DA 2026-07-24
ER
PT J
AU Immer, FF
   Durrer, M
   Mühlemann, KS
   Erni, D
   Gahl, B
   Carrel, TP
AF Immer, FF
   Durrer, M
   Mühlemann, KS
   Erni, D
   Gahl, B
   Carrel, TP
TI Deep sternal wound infection after cardiac surgery: Modality of
   treatment and outcome
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID POSTOPERATIVE MEDIASTINITIS; COMPLICATIONS
AB Background. Deep sternal wound infection is a serious and expensive complication after cardiac surgical procedures. We tried to identify risk factors for failure of vacuum-assisted sternal closure and compare the outcome and long-term quality of life (QoL) with the results obtained after sternal resection and muscle flap.
   Methods. Between January 1998 and December 2003, 5,690 patients under-went cardiac surgical procedures at our institution. Fifty-five patients who had deep sternal wound infection were identified between January 1998 and December 2003. In-hospital data were assessed and the outcome was analyzed. QoL, using the Short Form 36 Health Survey Questionnaire (SF-36), was assessed and an additional questionnaire focused on specific problems.
   Results. Overall mortality was 5.4%. Patients with successful vacuum-assisted sternal closure were younger and had fewer cumulative risk factors (chronic obstructive pulmonary disease, bilateral internal mammary artery, obesity, diabetes), than patients in whom secondary closure failed. Quality of life was better among patients with secondary vacuum-assisted closure than among patients with musculocutaneous flap. Independently of the modality of treatment, pain was not a serious problem reported by the patients during the follow-up.
   Conclusions. We conclude that preservation of the sternum should be the principal aim of surgical treatment in patients with deep sternal wound infection. Early diagnosis, aggressive surgical treatment by debridement, and the use of vacuum-assisted systems allows us to achieve a good long-term result with nearly normal QoL. Resection and musculocutaneous flap is a therapeutic option for high-risk patients, providing a safe, effective control of the infection, and it leads to acceptable results in terms of pain control and QoL.
C1 Univ Hosp Bern, Dept Cardiovasc Surg, Inselspital, CH-3010 Bern, Switzerland.
   Univ Hosp Bern, Dept Infect Dis, Inselspital, CH-3010 Bern, Switzerland.
   Univ Hosp Bern, Div Plast Surg, Inselspital, CH-3010 Bern, Switzerland.
C3 University of Bern; University Hospital of Bern; University of Bern;
   University Hospital of Bern; University of Bern; University Hospital of
   Bern
RP Immer, FF (通讯作者)，Univ Hosp Bern, Dept Cardiovasc Surg, Inselspital, CH-3010 Bern, Switzerland.
EM franzimmer@yahoo.de
RI Carrel, Thierry/AAI-5910-2021
OI Gahl, Brigitta/0000-0001-8123-0438
CR BLANCHARD A, 1995, EUR J CARDIO-THORAC, V9, P153, DOI 10.1016/S1010-7940(05)80064-8
   Borger MA, 1998, ANN THORAC SURG, V65, P1050, DOI 10.1016/S0003-4975(98)00063-0
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NR 21
TC 68
Z9 79
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD SEP
PY 2005
VL 80
IS 3
BP 957
EP 961
DI 10.1016/j.athoracsur.2005.03.035
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 961TC
UT WOS:000231683700030
PM 16122463
OA Bronze
DA 2026-07-24
ER
PT J
AU Mendonca, DA
   Cosker, T
   Makwana, NK
AF Mendonca, DA
   Cosker, T
   Makwana, NK
TI Vacuum-assisted closure to aid wound healing in foot and ankle surgery
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE diabetic ulcers; vacuum-assisted closure; wound closure
ID DEGLOVING INJURIES; RANDOMIZED-TRIAL; EXPERIENCE; MANAGEMENT; THERAPY;
   DEVICE; ULCERS
AB Background. Although vacuum-assisted closure (VAC) is a well-established technique in other surgical specialties, its use has not been established in the foot and ankle. The aims of this study were to determine if vacuum-assisted closure therapy (VAC) helps assist closure in diabetic foot ulcers and wounds secondary to peripheral vascular disease, if it helps debride wounds, and if it prevents the need for further surgery. Methods: We retrospectively reviewed 15 patients (18 wounds or ulcers) with primary diagnoses of diabetes (10 patients), chronic osteomyelitis (two patients), peripheral vascular disease (two patients), and spina bifida (one patient). Eleven of the 15 patients had serious comorbidities, such as peripheral neuropathy, renal failure, and wound dehiscence. All wounds were surgically debrided before VAC therapy was applied according to the manufacturer's instructions. The main outcome measures were time to satisfactory wound closure, changes in the wound surface area, and the need for further surgery. Results: Satisfactory healing was achieved in 13 of the 18 wounds or ulcers at an average of 2.5 months. VAC therapy failed in five patients (five class III ulcers), three of whom required below-knee amputations. Wound or ulcer size decreased from an average of 7.41 cm(2) before treatment to an average of 1.58 cm(2) after treatment. Conclusion: VAC therapy is a useful adjunct to the standard treatment of chronic wound or ulcers in patients with diabetes or peripheral vascular disease. Its use in foot and ankle surgery leads to a quicker wound closure and, in most patients, avoids the need for further surgery.
C1 Wrexham Maelor Hosp, Dept Orthopaed & Trauma, Wrexham, Wales.
RP Mendonca, DA (通讯作者)，10 St Davids Court,Holt Rd, Wrexham LL13 9AN, Wales.
EM derickmen@yahoo.com
OI Mendonca, Derek Amith/0000-0002-7861-1966
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta PA, 2002, OBSTET GYNECOL, V99, P497, DOI 10.1016/S0029-7844(01)01752-5
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Ballard K, 2001, Br J Nurs, V10, pS6
   Baynham S A, 1999, Ostomy Wound Manage, V45, P28
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   DeFranzo AJ, 1999, PLAST RECONSTR SURG, V104, P2145, DOI 10.1097/00006534-199912000-00031
   Falanga Vincent, 1992, Journal of Dermatology (Tokyo), V19, P667
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Gwan-Nulla DN, 2001, ANN PLAS SURG, V47, P552, DOI 10.1097/00000637-200111000-00014
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   Wagner F W Jr, 1981, Foot Ankle, V2, P64
   WYSOCKI AB, 1993, J INVEST DERMATOL, V101, P64, DOI 10.1111/1523-1747.ep12359590
NR 20
TC 29
Z9 34
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD SEP
PY 2005
VL 26
IS 9
BP 761
EP 766
DI 10.1177/107110070502600915
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 963DH
UT WOS:000231783000016
PM 16174508
DA 2026-07-24
ER
PT J
AU Arca, MJ
   Somers, KK
   Derks, TE
   Goldin, AB
   Aiken, JJ
   Sato, TT
   Shilyansky, J
   Winthrop, A
   Oldham, KT
AF Arca, MJ
   Somers, KK
   Derks, TE
   Goldin, AB
   Aiken, JJ
   Sato, TT
   Shilyansky, J
   Winthrop, A
   Oldham, KT
TI Use of vacuum-assisted closure system in the management of complex
   wounds in the neonate
SO PEDIATRIC SURGERY INTERNATIONAL
LA English
DT Article
DE vacuum-assisted closure; VAC; premature infants
AB The vacuum-assisted closure (VAC) system has become an accepted treatment modality for acute and chronic wounds in adults. The use of negative-pressure dressing has been documented in adults and, to some extent, in children. However, its use in premature infants has not been reported in the literature. The results of using the VAC system were examined in two premature infants with complex wounds. The VAC system was found to be effective in facilitating the closure of large and complex wounds in these patients. Complete epithelialization of the wounds was achieved in both patients without skin grafting. In conclusion, in two premature neonates with extraordinary soft tissue defects, the VAC system was a safe and effective choice to assist in closing these wounds.
C1 Med Coll Wisconsin, Childrens Hosp Wisconsin, Div Pediat Surg, Milwaukee, WI 53226 USA.
C3 Children's Hospital of Wisconsin; Medical College of Wisconsin
RP Arca, MJ (通讯作者)，Med Coll Wisconsin, Childrens Hosp Wisconsin, Div Pediat Surg, 9000 W Wisconsin Dr,POB 1997, Milwaukee, WI 53226 USA.
EM marca@chw.org
RI Derks, Terry/AGT-9822-2022
OI Derks, Terry/0000-0002-7259-1095; Sato, Thomas/0000-0001-6547-6403;
   Shilyansky, Joel/0000-0003-0766-4785
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brown KM, 2001, ANN THORAC SURG, V72, P1409, DOI 10.1016/S0003-4975(01)02844-2
   Conquest AM, 2003, J SURG RES, V115, P209, DOI 10.1016/S0022-4804(03)00331-7
   Mooney J F 3rd, 2000, Clin Orthop Relat Res, P26, DOI 10.1097/00003086-200007000-00005
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Ramnarine IR, 2002, EUR J CARDIO-THORAC, V22, P1029, DOI 10.1016/S1010-7940(02)00562-6
   TEICH S, 2004, 35 ANN M FIN PROGR, pA143
NR 7
TC 23
Z9 31
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-0358
EI 1437-9813
J9 PEDIATR SURG INT
JI Pediatr. Surg. Int.
PD JUL
PY 2005
VL 21
IS 7
BP 532
EP 535
DI 10.1007/s00383-005-1465-y
PG 4
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 965IE
UT WOS:000231943000006
PM 15965692
DA 2026-07-24
ER
PT J
AU Agarwal, JP
   Ogilvie, M
   Wu, LC
   Lohman, RF
   Gottlieb, LJ
   Franczyk, M
   Song, DH
AF Agarwal, JP
   Ogilvie, M
   Wu, LC
   Lohman, RF
   Gottlieb, LJ
   Franczyk, M
   Song, DH
TI Vacuum-assisted closure for sternal wounds: A first-line therapeutic
   management approach
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID RISK-FACTORS; POSTSTERNOTOMY MEDIASTINITIS; MUSCLE FLAPS; FIXATION;
   SURGERY
AB Background: Vacuum-assisted closure therapy has gained widespread use since its introduction in 1997. Previous studies have attributed significant benefit to its use for treatment of sternal wounds with or without mediastinitis. Management of sternal wounds with this therapy has been shown to decrease the number of dressing changes, reduce the time between debridement and definitive closure, and reduce costs associated with a protracted course of in-hospital dressing changes. The therapy has been used both as a bridge between debridement and definitive closure and as a catalyst to secondary sternal-wound healing.
   Methods: The authors performed a retrospective review of 103 patients who underwent vacuum-assisted closure therapy after median sternotomy between June of 1999 and March of 2004 at a single institution. The wounds were classified as sterile wounds, superficial sternal infections, and mediastinitis. The wound closure device, consisting of a polyurethane sponge and evacuation tube with inline suction, was applied sterilely to A wounds over a layer of Acticoat.
   Results: Vacuum-assisted closure was utilized in the treatment of sternal wounds for 103 patients (67 male patients and 36 female patients) whose mean age was 52 years (range, 3 months to 91 years). Patient comorbidities included diabetes, chronic obstructive pulmonary disease, end-stage renal disease, immunosuppression, and others. Sixty-four percent of the patients had a diagnosis of mediastinitis; 36 percent had either superficial infections or a sterile wound. The therapy was utilized for an average period of 11 days per patient. Sixty-eight percent of the patients (70 of 103) had definitive chest closure with open reduction internal fixation and/or flap closure. The remaining 32 percent had no definitive closure method. The overall mortality rate was 28 percent (29 of 103 patients), although no deaths were directly related to use of the therapy, and only four deaths resulted from sepsis as a consequence of mediastinitis.
   Conclusions: The authors report the largest series of patients treated with this therapy for post-sternotomy sternal wounds and believe it is safe and effective as a first-line therapy in the management of sternal wounds. The mortality rate from their study represents the patients' underlying disease process and comorbidities and is not a reflection of complications associated with the therapy. Vacuum-assisted closure ther-apy has been shown to decrease wound edema, decrease the time to definitive closure, and reduce wound bacterial colony counts. The authors have implemented the therapy for most patients with sternal wounds/mediastinitis at their institution, and believe it should be a standard protocol in the first-line management of these types of wounds.
C1 Univ Chicago Hosp, Plast & Reconstruct Surg Sect, Chicago, IL 60637 USA.
   Univ Chicago Hosp, Dept Phys Therapy, Chicago, IL 60637 USA.
C3 University of Illinois System; University of Chicago; University of
   Chicago Medical Center; University of Illinois System; University of
   Chicago; University of Chicago Medical Center
RP Song, DH (通讯作者)，Univ Chicago Hosp, Plast & Reconstruct Surg Sect, 5841 S Maryland Ave,MC 6035, Chicago, IL 60637 USA.
EM dsong@surgery.bsd.uchicago.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 18
TC 75
Z9 88
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP 15
PY 2005
VL 116
IS 4
BP 1035
EP 1040
DI 10.1097/01.prs.0000178401.52143.32
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 967TP
UT WOS:000232114400018
PM 16163091
DA 2026-07-24
ER
PT J
AU Repta, R
   Ford, R
   Hoberman, L
   Rechner, B
AF Repta, R
   Ford, R
   Hoberman, L
   Rechner, B
TI The use of negative-pressure therapy and skin grafting in the treatment
   of soft-tissue defects over the Achilles tendon
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE Achilles; wound; reconstructions; negative-pressure therapy
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE; WOUNDS
AB Management of soft-tissue defects over the Achilles tendon presents specific challenges to the plastic surgeon. Primary closure or local flaps are often not feasible repair options or such wounds, and many of these patients may be poor candidates for free-tissue transfer secondary to their comorbidity. In this case series, the use of negative-pressure therapy in the preoperative period to prepare the wound bed for placement of a split-thickness skin graft and in the immediate postoperative period as a dressing for the graft was successfully used in 3 patients with soft-tissue defects over the Achilles tendon with exposed tendon. All 3 patients had stable wounds at 48 to 80 months postoperatively. Negative-pressure therapy and skin grafting was found to be a reliable method of repair that provided stable coverage for such wounds.
C1 GRAMEC, Div Plast Surg, Grand Rapids, MI USA.
C3 Michigan State University; Michigan State University Hospital
RP Repta, R (通讯作者)，221 Michigan St,NE,Suite 200A, Grand Rapids, MI 49503 USA.
EM remusreptamd@hotmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ATTINGER C, 1995, J AM PODIAT MED ASSN, V85, P49, DOI 10.7547/87507315-85-1-49
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Leppilahti J, 1996, CLIN ORTHOP RELAT R, P171
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   SWARTZ WM, 1985, PLAST RECONSTR SURG, V76, P364, DOI 10.1097/00006534-198509000-00005
NR 8
TC 23
Z9 28
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2005
VL 55
IS 4
BP 367
EP 370
DI 10.1097/01.sap.0000181342.25065.60
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 970CM
UT WOS:000232282800007
PM 16186700
DA 2026-07-24
ER
PT J
AU Friedman, T
   Westreich, M
   Shalom, A
AF Friedman, T
   Westreich, M
   Shalom, A
TI Vacuum-assisted closure treatment complicated by anasarca
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE vacuum-assisted treatment; hypoalbuminemia; anasarca; compromised
   patient; rare complication
ID WOUND CONTROL
AB The vacuum-assisted closure system has proven to be effective and safe in the treatment of a variety of wound types. in this case report, we present a rare complication of anasarca due to hypoalbuminemia, which developed during vacuum-assisted closure treatment. The patient was known to suffer from clinically stable congestive heart failure and had not had previous hypoalbuminemia. We emphasize the need for careful monitoring of electrolytes and proteins in compromised patients that have marked wound drainage when they are treated with a negative-pressure apparatus.
C1 Assaf Harofeh Med Ctr, Dept Plast Surg, IL-70300 Zerifin, Israel.
   Tel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel.
C3 Tel Aviv University; Shamir Medical Center (Assaf Harofeh); Tel Aviv
   University; Sackler Faculty of Medicine
RP Friedman, T (通讯作者)，Assaf Harofeh Med Ctr, Dept Plast Surg, IL-70300 Zerifin, Israel.
EM mony@netvision.net.il
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Bucalo Brian, 1993, Wound Repair and Regeneration, V1, P181, DOI 10.1046/j.1524-475X.1993.10308.x
   Meara JG, 1999, ANN PLAS SURG, V42, P589, DOI 10.1097/00000637-199906000-00002
   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 8
TC 9
Z9 10
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2005
VL 55
IS 4
BP 420
EP 421
DI 10.1097/01.sap.0000174361.52084.6e
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 970CM
UT WOS:000232282800018
PM 16186711
DA 2026-07-24
ER
PT J
AU Sjögren, J
   Nilsson, J
   Gustafsson, R
   Malmsjö, M
   Ingemansson, R
AF Sjögren, J
   Nilsson, J
   Gustafsson, R
   Malmsjö, M
   Ingemansson, R
TI The impact of vacuum-assisted closure on long-term survival after
   post-sternotomy mediastinitis
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID STERNAL WOUND-INFECTION; RISK-FACTORS; EUROPEAN SYSTEM; MUSCLE FLAPS;
   COMPLICATIONS; THERAPY; MANAGEMENT; MORTALITY; SURGERY
AB Background. Post-sternotomy mediastinitis after coronary artery bypass grafting is reported to be a strong predictor for poor late survival when using conventional wound-healing therapies. The aim of this study was to compare the long-term survival after vacuum-assisted closure treated mediastinitis following coronary artery bypass grafting with that of patients without mediastinitis. Another objective was to identify risk factors for developing mediastinitis.
   Methods. Forty-six patients were treated for mediastinitis, with vacuum-assisted closure but without additional tissue flaps, after isolated coronary bypass grafting between January 1999 and September 2004. During this period, 4,781 patients underwent isolated coronary bypass grafting without mediastinitis. Actuarial survival was compared with the log-rank test. Univariate and multivariate analysis were used to identify risk factors for mediastinitis.
   Results. There was no difference in early or late survival between the mediastinitis group treated with vacuum-assisted closure and the control group (p = not significant). The survival at 1, 3, and 5 years was 92.9% +/- 4.0%, 89.2% +/- 5.2%, and 89.2% +/- 5.2%, respectively, in the vacuum-assisted closure group; and 96.5% +/- 0.3%, 92.1% +/- 0.5%, and 86.9% +/- 0.8%, respectively, in the control group. Diabetes mellitus, low left ventricular ejection fraction, obesity, renal failure, and three-vessel disease were identified as risk factors for developing mediastinitis.
   Conclusions. This study suggests that patients with vacuum-assisted closure treated mediastinitis may have similar long-term survival as patients without mediastinitis after coronary artery bypass grafting. The independent risk factors identified were similar to those found in previous studies. Our data support that vacuum-assisted closure therapy minimizes the negative effects of mediastinitis on late survival after coronary artery bypass grafting.
C1 Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, SE-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Internal Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Sjögren, J (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, SE-22185 Lund, Sweden.
EM johan.sjogren@thorax.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021; Nilsson, Johan/A-4742-2011
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953; Nilsson, Johan/0000-0001-6860-6090
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NR 38
TC 88
Z9 96
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2005
VL 80
IS 4
BP 1270
EP 1275
DI 10.1016/j.athoracsur.2005.04.010
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 972GK
UT WOS:000232442100017
PM 16181853
DA 2026-07-24
ER
PT J
AU Yuh, DD
   Albaugh, M
   Ullrich, S
   Conte, JV
AF Yuh, DD
   Albaugh, M
   Ullrich, S
   Conte, JV
TI Treatment of ventricular assist device driveline infection with
   vacuum-assisted closure system
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID WOUND CONTROL
AB Deep driveline infection is a serious complication after left ventricular assist device implantation. Current treatment strategies are associated with significant morbidity related to healing or relocation of the driveline tract. We present a case of deep driveline infection successfully treated with a vacuum-assisted closure system as a potentially improved alternative therapy.
C1 Johns Hopkins Univ Hosp, Div Cardiac Surg, Baltimore, MD 21287 USA.
C3 Johns Hopkins University; Johns Hopkins Medicine
RP Yuh, DD (通讯作者)，Johns Hopkins Univ Hosp, Div Cardiac Surg, 600 N Wolfe St,Blalock 618, Baltimore, MD 21287 USA.
EM dyuh@csurg.jhmi.jhu.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   FISHER SA, 1997, CLIN INFECT DIS, V24, P18
   Grossi P, 2001, TRANSPLANT P, V33, P1969, DOI 10.1016/S0041-1345(00)02757-3
   Holman WL, 2003, ANN THORAC SURG, V75, pS48, DOI 10.1016/S0003-4975(03)00479-X
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Pasque MK, 2002, ANN THORAC SURG, V74, P1267, DOI 10.1016/S0003-4975(02)03752-9
   Rose EA, 2001, NEW ENGL J MED, V345, P1435, DOI 10.1056/NEJMoa012175
NR 8
TC 22
Z9 24
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2005
VL 80
IS 4
BP 1493
EP 1495
DI 10.1016/j.athoracsur.2004.03.043
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 972GK
UT WOS:000232442100052
PM 16181898
DA 2026-07-24
ER
PT J
AU Ford, SJ
   Rathinam, S
   King, JE
   Vaughan, R
AF Ford, SJ
   Rathinam, S
   King, JE
   Vaughan, R
TI Tuberculous osteomyelitis of the sternum: Successful management with
   debridement and vacuum assisted closure
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE sternal osteomyetitis; vacuum assisted closure; tuberculosis
ID FLAP
AB Primary Mycobacterial infection of the sternum is an exceedingly rare occurrence. We present a case of tuberculous osteomyelitis of the sternum successfully treated with surgical debridement and vacuum-assisted closure therapy. (c) 2005 Elsevier B.V. All rights reserved.
C1 Birmingham Heartlands Hosp, Reg Dept Thorac Surg, Birmingham B9 5SS, W Midlands, England.
C3 Heart of England NHS Foundation Trust; Heartlands Hospital; University
   of Birmingham
RP Rathinam, S (通讯作者)，Birmingham Heartlands Hosp, Reg Dept Thorac Surg, Bardesley Green E, Birmingham B9 5SS, W Midlands, England.
EM srathinam@rcsed.ac.uk
OI Ford, Samuel/0000-0002-1739-964X; vaughan, roger/0000-0001-6066-4595
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NR 8
TC 15
Z9 18
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD OCT
PY 2005
VL 28
IS 4
BP 645
EP 647
DI 10.1016/j.ejcts.2005.05.030
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 974GX
UT WOS:000232580500028
PM 16179195
DA 2026-07-24
ER
PT J
AU Rijkenhuizen, ABM
   van den Boom, R
   Landman, M
   Cornelissen, BPM
AF Rijkenhuizen, ABM
   van den Boom, R
   Landman, M
   Cornelissen, BPM
TI Can Vacuum assisted wound management enhance graft acceptance?
SO PFERDEHEILKUNDE
LA English
DT Article
DE surgery; traumatology; woundtreatment; skin grafting; vacuum assisted
ID SKIN-GRAFTS; CLOSURE; PRESSURE; THERAPY
AB Vacuum-assisted wound closure (VAC), a novel innovation in wound-care, has been proven to promote wound healing in human medicine and was recently also described for the treatment of a neck wound in a horse. It ensures adequate wound drainage, a moist wound-healing environment, increased rate of granulation tissue formation, improved blood flow and reduced bacterial count. The results of the application of VAC as a supportive therapy in skin grafting are encouraging in human patients with take rates of grafts above 90%. The question is whether these results can also be obtained in horses. This article reports the clinical application of VAC in combination with the Meek micrografting method in 2 equine patients. The VAC provided adequate wound drainage, good fixation of the graft to the recipient site, limited shear forces and allowed graft acceptance of at least 75% in both patients. Although no control studies were conducted, the clinical results suggest that vacuum-assisted closure stimulates the acceptance of split thickness grafts and accelerates wound healing and may become an essential part of wound treatment in the future.
C1 Univ Utrecht, Fac Vet Med, Dept Equine Sci, NL-3584 CM Utrecht, Netherlands.
C3 Utrecht University
RP Rijkenhuizen, ABM (通讯作者)，Univ Utrecht, Fac Vet Med, Dept Equine Sci, Yalelaan 12, NL-3584 CM Utrecht, Netherlands.
EM a.rijkenhuizen@vet.uu.nl
CR Argenta LC, 2000, ANN PLAS SURG, V45, P335, DOI 10.1097/00000637-200045030-00020
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
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   WILMINK JM, 2005, P VOORJAARSDAGEN 200
NR 16
TC 16
Z9 17
U1 0
U2 12
PU HIPPIATRIKA VERLAG MBH
PI STUTTGART
PA POSTFACH 102251, 70018 STUTTGART, GERMANY
SN 0177-7726
J9 PFERDEHEILKUNDE
JI Pferdeheilkunde
PD SEP-OCT
PY 2005
VL 21
IS 5
BP 413
EP 418
DI 10.21836/PEM20050503
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 974PB
UT WOS:000232602800003
OA Bronze
DA 2026-07-24
ER
PT J
AU Rosenthal, EL
   Blackwell, KE
   McGrew, B
   Carroll, WR
   Peters, GE
AF Rosenthal, EL
   Blackwell, KE
   McGrew, B
   Carroll, WR
   Peters, GE
TI Use of negative pressure dressings in head and neck reconstruction
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Article
DE fistula; head and neck cancer; wound care; negative pressure dressings;
   wound complications; otolaryngology; microvascular reconstruction; head
   and neck reconstruction
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Background. Head and neck microvascular surgery commonly requires management of complex wounds of the upper aerodigestive tract and donor sites. Negative pressure dressings have been reported to promote healing in compromised wounds.
   Methods. Between February 2001 and June 2004, data were collected in a retrospective manner on 23 patients who underwent treatment with negative pressure dressings at two tertiary care institutions.
   Results. Twenty-three patients underwent negative pressure wound treatment for donor site complications (n = 9) or head and neck wounds (n = 14) with a minimum of 5 months follow-up. Average duration of treatment was 6.5 days. Indications for use in wound complications included wound breakdown (n = 3), fistula with carotid exposure (n = 4), tendon exposure of donor site (n = 6). and others (n = 3). On average, granulation tissue was promoted in across 93% of the wound bed over the course of treatment. Two patients with anterior mandibular hardware exposure were managed successfully with negative pressure dressings. Large split-thickness skin grafts (average size, 135 cm(2)) at mobile sites were bolstered with negative pressure dressings in seven patients with an overall take rate of 74%.
   Conclusion, Although of limited use as a bolster for split-thickness skin grafts, negative pressure dressings are safe and effective in the management of complex head and neck wounds and in the treatment of donor site complications. (c) 2005 Wiley Periodicals, Inc.
C1 Univ Alabama Birmingham, Dept Surg, Div Otolaryngol, Birmingham, AL 35294 USA.
   Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Div Head & Neck Surg, Los Angeles, CA USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA
RP Rosenthal, EL (通讯作者)，Univ Alabama Birmingham, Dept Surg, Div Otolaryngol, BDB Suite 563,1530 3rd Ave S, Birmingham, AL 35294 USA.
EM Eben.rosenthal@ccc.uab.edu
RI Rosenthal, Eben/KLC-3513-2024
OI Rosenthal, Eben/0000-0003-0294-5203
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Avery C, 2000, INT J ORAL MAX SURG, V29, P198, DOI 10.1016/S0901-5027(00)80092-2
   Carson Stanley N, 2004, Ostomy Wound Manage, V50, P52
   Chang KP, 2001, BURNS, V27, P839, DOI 10.1016/S0305-4179(01)00052-3
   Cro C, 2002, POSTGRAD MED J, V78, P364, DOI 10.1136/pmj.78.920.364
   Isago T, 2003, J DERMATOL, V30, P673, DOI 10.1111/j.1346-8138.2003.tb00456.x
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Nienhuijs S W, 2003, J Wound Care, V12, P343
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Sibbald R Gary, 2003, Ostomy Wound Manage, V49, P52
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
NR 11
TC 29
Z9 34
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD NOV
PY 2005
VL 27
IS 11
BP 970
EP 975
DI 10.1002/hed.20265
PG 6
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA 977TL
UT WOS:000232826000007
PM 16127668
DA 2026-07-24
ER
PT J
AU Taub, PJ
   Schulman, MR
   Sett, S
   Koch, RM
AF Taub, PJ
   Schulman, MR
   Sett, S
   Koch, RM
TI Revisiting vascularized muscle flaps for complicated sternal wounds in
   children
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE sternal; wound; pediatric; muscle; flap
ID VACUUM-ASSISTED CLOSURE; DELAY PHENOMENON
AB Surgeons at our center previously reported a case of a 2-month-old infant who underwent closure of an infected sternal wound following open cardiac surgery with debridement followed by closure with bilateral pectoralis muscle flaps and a unilateral rectus abdominis muscle flap. The success of the procedure has spawned refinements in the technique, such as the one described herein. A 2-week-old neonate was evaluated for postoperative sternal dehiscence and instability following open cardiac surgery or severe congenital cardiac anomalies. Management included initial debridement and application of a vacuum-assisted closure (V.A.C.) system (KCI, Oxfordshire, UK). In conjunction with the final V.A.C. dressing change, the patient underwent delay of the left rectus muscle by division of the inferior epigastric pedicle. She subsequently underwent transposition of the left rectus muscle and application of a full-thickness skin graft for coverage of the sternal defect. She has since done well and still requires further invasive cardiac procedures.
C1 New York Med Coll, Div Plast & Reconstruct Surg, Valhalla, NY 10595 USA.
   Westchester Cty Med Ctr, Maria Fareri Childrens Hosp, Valhalla, NY 10595 USA.
C3 New York Medical College; Westchester Medical Center
RP Taub, PJ (通讯作者)，New York Med Coll, Div Plast & Reconstruct Surg, Macy Pavil, Valhalla, NY 10595 USA.
EM peter@pjtaub.com
CR Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   CALLEGARI PR, 1992, PLAST RECONSTR SURG, V89, P397, DOI 10.1097/00006534-199203000-00001
   Davydov Iu A, 1992, Khirurgiia (Mosk), P21
   HALLOCK GG, 1995, PLAST RECONSTR SURG, V96, P233, DOI 10.1097/00006534-199507000-00053
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
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   Sung K, 1998, ANN PLAS SURG, V40, P523, DOI 10.1097/00000637-199805000-00015
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   WEINZWEIG N, 1995, ANN PLAS SURG, V34, P471, DOI 10.1097/00000637-199505000-00004
NR 12
TC 8
Z9 9
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD NOV
PY 2005
VL 55
IS 5
BP 535
EP 537
DI 10.1097/01.sap.0000183681.56595.0a
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 979HC
UT WOS:000232932000020
PM 16258310
DA 2026-07-24
ER
PT J
AU Dosluoglu, HH
   Schimpf, DK
   Schultz, R
   Cherr, GS
AF Dosluoglu, HH
   Schimpf, DK
   Schultz, R
   Cherr, GS
TI Preservation of infected and exposed vascular grafts using vacuum
   assisted closure without muscle flap coverage
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 19th Annual Meeting of the Eastern-Vascular-Society
CY MAY 05-07, 2005
CL Pittsburgh, PA
SP Eastern Vasc Soc
ID NEGATIVE-PRESSURE; GROIN; MANAGEMENT; EXPERIENCE; SURGERY; THERAPY;
   BYPASS
AB The most widely used techniques for graft preservation after localized graft infections are muscle flap closure or antibacterial dressings and irrigations after debridement. Vacuum assisted closure (VAC has been increasingly used for complex wounds in vascular surgery, including groin infections, but not directly on exposed bypass grafts as a stand-alone technique. We used the VAC system after wound debridement in four patients with fully exposed synthetic bypass grafts who were too unstable or risky for further operative interventions. Mean duration of VAC use was 22.8 days (range, 6 to 5 3 days), with time to total wound closure of 30 to 63 days (mean, 41 days). There were no reinfections with I I to 25 months' follow-up (mean, 18.3 months). For high-risk surgical patients with a fully exposed infected prosthetic vascular graft, VAC therapy along with aggressive debridement and antibiotic therapy may be an effective alternative to current management strategies.
C1 SUNY Buffalo, Dept Surg, Buffalo, NY 14260 USA.
   Vet Affairs Med Ctr, Dept Vasc Surg, Buffalo, NY USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   US Department of Veterans Affairs; Veterans Health Administration (VHA)
RP Dosluoglu, HH (通讯作者)，VA Western NY Healthcare Syst, Div Vasc Surg, 3495 Bailey Ave, Buffalo, NY 14215 USA.
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NR 17
TC 60
Z9 63
U1 0
U2 0
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD NOV
PY 2005
VL 42
IS 5
BP 989
EP 992
DI 10.1016/j.jvs.2005.07.006
PG 4
WC Surgery; Peripheral Vascular Disease
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 981LL
UT WOS:000233090000035
PM 16275458
DA 2026-07-24
ER
PT J
AU Kaplan, M
   Banwell, P
   Orgill, DP
   Ivatury, RR
   Demetriades, D
   Moore, FA
   Miller, P
   Nicholas, J
   Henry, S
AF Kaplan, M
   Banwell, P
   Orgill, DP
   Ivatury, RR
   Demetriades, D
   Moore, FA
   Miller, P
   Nicholas, J
   Henry, S
TI Guidelines for the management of the open abdomen
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; MULTIPLE ORGAN FAILURE; ASSISTED FASCIAL
   CLOSURE; PLANNED VENTRAL HERNIA; VACUUM PACK TECHNIQUE;
   INTENSIVE-CARE-UNIT; WOUND CLOSURE; INTRAABDOMINAL HYPERTENSION;
   DAMAGE-CONTROL; TEMPORARY CLOSURE
AB The management of the open abdomen continues to pose a challenge for Surgeons. After Surgical exploration for abdominal trauma, operative misadventure, or relief of abdominal compartment syndrome, definitive closure of the abdominal fascia and abdominal wall immediately following laparotomy may be technically impossible. Alternatively, the abdomen may need to remain open to allow access for re-operation and time for decompression of the abdomen.
   Multiple techniques for temporary abdominal closure have been described in the literature. To better understand the current treatment of the open abdomen, an expert panel of surgeons convened to review the literature and current practices in managing the open abdomen. The panel reviewed the reasons for the increasing number of open abdomen procedures as well as each treatment method in the context of evidence-based medicine. In addition, panel members shared their experiences using various techniques for treating the open abdomen.
   The use of the open abdomen as a surgical option has increased in recent years. Benefits of maintaining an open abdomen include ease of re-exploration, control of abdominal contents, reduction of the risk of intra-abdominal hypertension and abdominal compartment syndrome, and fascial preservation for Closure of the abdominal wall. The prolonged exposure of abdominal viscera can result in high rates of complications, including infection, sepsis, and fistula formation.
   A number of techniques have been published, but no clear consensus on the best technique or device to manage an open abdomen exists. Recent intensive care unit advances, an awareness of intra-abdominal hypertension and abdominal compartment syndrome, and the increased usage of damage control laparotomy have resulted in a new class of challenging patients with open abdominal wounds.
   Temporary abdominal closure techniques, such as the Bogota bag or vacuum pack, have been described, along with other closure techniques, including allowing the wound to granulate through a biodegradable mesh and sequential closure using a Vacuum Assisted Closure (R) device (VA.C.(R) Therapy (TM), KCI, San Antonio, Tex). Each of these methods is reported to reduce complications compared to traditional gauze dressings. The V.A.C.(R) System allows surgeons to close most open abdomens without the use of skin grafts. Future studies and continued innovation will hopefully lead to better understanding of optimal treatment strategies for these devastating injuries.
RI Orgill, Dennis/H-7596-2019; Ivatury, Rao/H-2922-2019
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   2004, WORLD C ABD COMP SYN
NR 62
TC 38
Z9 58
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2005
SU S
BP 1
EP 24
PG 24
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 982GI
UT WOS:000233145700001
DA 2026-07-24
ER
PT J
AU Shirakawa, M
   Isseroff, RR
AF Shirakawa, M
   Isseroff, RR
TI Topical negative pressure devices - Use for enhancement of healing
   chronic wounds
SO ARCHIVES OF DERMATOLOGY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL;
   CLINICAL-EXPERIENCE; SUBATMOSPHERIC PRESSURE; THERAPY; MANAGEMENT;
   DRESSINGS; ULCERS
AB Chronic wounds present a significant challenge, because there are few available treatment options for timely healing. Topical negative pressure devices, have been used in a number of different types of wounds, including chronic wounds. They are believed to hasten wound healing by (1) maintaining A moist environment, (2) removing wound exudates, (3) increasing local blood flow, (4) increasing granulation tissue formation, (5) applying mechanical pressure to promote wound closure, band (6) reducing bacterial loads in the wound. Multiple nonrandomized, noncontrolled studies have,reported that the use of these devices results in faster, healing times and more successful closures. Five small randomized, controlled trials have also shown favorable outcomes with the use of topical negative pressure devices compared with conventional treatment. Adverse effects include discomfort, pain, and excessive tissue growth into the dressing. Complications are limited if the device is used properly. In light of the current treatment options, topical negative pressure devices may be considered useful as adjuvant therapy for chronic wounds; however, there is inadequate definitive evidence that wound healing is substantially better with these devices than with traditional therapy.
C1 Univ Calif Davis, Sch Med, Dept Dermatol, Davis, CA 95616 USA.
   Sacromento Vet Affairs Med Ctr, Wound Healing Clin, Maher, CA USA.
C3 University of California System; University of California Davis
RP Isseroff, RR (通讯作者)，Univ Calif Davis, Sch Med, Dept Dermatol, TB 192,1 Shields Ave, Davis, CA 95616 USA.
EM rrisseroff@ucdavis.edu
RI Isseroff, Roslyn/HPH-5753-2023
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 32
TC 25
Z9 30
U1 0
U2 6
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-987X
EI 1538-3652
J9 ARCH DERMATOL
JI Arch. Dermatol.
PD NOV
PY 2005
VL 141
IS 11
BP 1449
EP 1453
DI 10.1001/archderm.141.11.1449
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 982SU
UT WOS:000233182700013
PM 16301393
DA 2026-07-24
ER
PT J
AU Armstrong, DG
   Lavery, LA
AF Armstrong, DG
   Lavery, LA
CA Diabet Foot Study Consortium
TI Negative pressure wound therapy after partial diabetic foot amputation:
   a multicentre, randomised controlled trial
SO LANCET
LA English
DT Article
ID MANAGEMENT; ULCERS; RISK; DERMAGRAFT
AB Background Diabetic foot wounds, particularly those secondary to amputation, are very complex and difficult to treat. We investigated whether negative pressure wound therapy (NPWT) improves the proportion and rate of wound healing after partial foot amputation in patients with diabetes.
   Methods We enrolled 162 patients into a 16-week, 18-centre, randomised clinical trial in the USA. Inclusion criteria consisted of partial foot amputation wounds up to the transmetatarsal level and evidence of adequate perfusion. Patients who were randomly assigned to NPWT (n=77) received treatment with dressing changes every 48 h. Control patients (n=85) received standard moist wound care according to consensus guidelines. NPWT was delivered through the Vacuum Assisted Closure (VAC) Therapy System. Wounds were treated until healing or completion of the 112-day period of active treatment. Analysis was by intention to treat. This study has been registered with ClinicalTrials.gov, number NCT00224796.
   Findings More patients healed in the NPWT group than in the control group (43 [56%] vs 33 [39%], p=0.040). The rate of wound healing, based on the time to complete closure, was faster in the NPWT group than in controls (p=0.005). The rate of granulation tissue formation, based on the time to 76-100% formation in the wound bed, was faster in the NPWT group than in controls (p=0.002). The frequency and severity of adverse events (of which the most common was wound infection) were similar in both treatment groups.
   Interpretation NPWT delivered by the VAC Therapy System seems to be a safe and effective treatment for complex diabetic foot wounds, and could lead to a higher proportion of healed wounds, faster healing rates, and potentially fewer re-amputations than standard care.
C1 Rosalind Franklin Univ Med & Sci, Scholls Ctr Lower Extrem Ambulatory Res, Chicago, IL 60064 USA.
   Texas A&M Univ, Hlth Sci Ctr, Coll Med, Scott & White Hosp,Dept Surg, Temple, TX USA.
C3 Chicago Medical School; Rosalind Franklin University of Medicine &
   Science; Texas A&M University System; Texas A&M University College
   Station; Texas A&M Health Science Center
RP Armstrong, DG (通讯作者)，Rosalind Franklin Univ Med & Sci, Scholls Ctr Lower Extrem Ambulatory Res, Chicago, IL 60064 USA.
EM Armstrong@usa.net
OI Lavery, Lawrence/0000-0002-7920-9952
CR [Anonymous], 2004, WOUNDS, p3S
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NR 43
TC 700
Z9 830
U1 4
U2 117
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD NOV 12
PY 2005
VL 366
IS 9498
BP 1704
EP 1710
DI 10.1016/S0140-6736(05)67695-7
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 983BP
UT WOS:000233206400025
PM 16291063
DA 2026-07-24
ER
PT J
AU Keel, M
   Trentz, O
AF Keel, M
   Trentz, O
TI Acute management of pelvic ring fractures
SO CURRENT ORTHOPAEDICS
LA English
DT Article; Proceedings Paper
CT 71st Annual Meeting of the American-Academy-of-Orthopaedic-Surgeons
CY MAR 10-14, 2004
CL San Francisco, CA
SP Amer Acad Orthopaed Surg
DE pelvic ring fracture; life-saving surgery; damage control; pelvic
   C-clamp; pelvic packing; angiographic embolisation; second took;
   vacuum-assisted closure; early total care; delayed definitive surgery
ID DAMAGE-CONTROL; LAPAROTOMY; HEMORRHAGE
AB During the primary survey, patients with pelvic ring fractures undergo decision making for day 1 surgery including life-saving surgery, damage control surgery and early total care or delayed definitive surgery dependent on haemodynamic status, physiologic criteria (hypothermia, coagulopathy, acidosis), scoring of injury severity and personal or operative resources. The staged sequential procedures of 'pelvic damage control' include damage control surgery with control of haemorrhage and contamination, decompression of abdominal and pelvic compartment syndromes, debridement of soft tissue injuries as well as temporary or definitive osteosynthesis, followed by resuscitation in the intensive care unit, 'second-look' operations, scheduled definitive surgery and secondary reconstructive surgery. External fixation of the posterior pelvic ring by pelvic C-clamp and pelvic packing represent the work horses for haemorrhage control of severe pelvic ring injuries in haemodynamically unstable patients, whereas angiographic embolisation is an option for haemodynamically stable patients or persistent bleeding after or during damage control surgery. (C) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Zurich Hosp, Div Trauma Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Keel, M (通讯作者)，Univ Zurich Hosp, Div Trauma Surg, Raemistr 100, CH-8091 Zurich, Switzerland.
EM marius.keel@u.sz.ch; otmar.trentz@usz.ch
CR *ADV TRAUM LIF SUP, 1997, INSTR COURS MAN
   Cook RE, 2002, J BONE JOINT SURG BR, V84B, P178, DOI 10.1302/0301-620X.84B2.12324
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NR 20
TC 3
Z9 4
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0268-0890
J9 CURR ORTHOPAED
JI Curr. Orthop.
PD OCT
PY 2005
VL 19
IS 5
BP 334
EP 344
DI 10.1016/j.cuor.2005.09.009
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics
GA 989IM
UT WOS:000233666100002
DA 2026-07-24
ER
PT J
AU Kneser, U
   Bach, AD
   Polykandriotis, E
   Kopp, J
   Horch, RE
AF Kneser, U
   Bach, AD
   Polykandriotis, E
   Kopp, J
   Horch, RE
TI Delayed reverse sural flap for staged reconstruction of the foot and
   lower leg
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 34th Annual Meeting of the German-Association-of-Plastic-Surgeons
CY SEP, 2004
CL Dusseldorf, GERMANY
SP German Assoc Plast Surg
ID FASCIOCUTANEOUS FLAP; NEUROFASCIOCUTANEOUS FLAPS; CLINICAL-EXPERIENCE;
   ARTERY FLAPS; COVERAGE; MUSCLE; WOUNDS; HEEL
AB Background: Soft-tissue defects of the foot and lower leg caused by traumatic injury, tumor ablation, or infection associated with osteomyelitis often require coverage by flaps. One excellent option for reconstruction of these defects is the distally based neurofasciocutaneous sural flap. It allows rapid and reliable coverage of defects from the distal third of the lower leg to the forefoot without significant functional donor-site morbidity. However, the maximal size of the flap is limited by the delicate perfusion of the arterial network associated with the superficial sensory nerve. Delay procedures may increase the reliability of large sural flaps.
   Methods: The authors successfully used delayed sural flaps based on a two-step procedure for the treatment of 11 patients (three women and eight men, age 50.1 +/- 20.0 years) with osteomyelitis (n = 3), melanoma (n = 3), sat-coma (n = 1), squamous cell carcinoma (n = 1), posttraumatic defects (n = 2), and recurrent gouty ulcer (n = 1). The delay period ranged from 7 to 15 days (9.7 3.1), the length of the flap was from 9 to 19 (14.8 +/- 3.0) cm, and the width of the flap from 7 to 12 (9.2 +/- 1.3) cm. Temporary wound Coverage was achieved by vacuum-assisted closure during the delay period.
   Results: All defects were covered successfully without major complications.
   Conclusions: The delay procedure positively affects the viability of large sural neurofasciocutaneous flaps. The authors recommend this modification for patients with large defects at the distal third of the lower leg or foot, requiring a two-step surgical approach due to the underlying disease.
C1 Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Kneser, U (通讯作者)，Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM ulrich.kneser@chir.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353; Polykaniotis,
   Elias/0000-0002-8152-6420
CR Al-Qattan MM, 2001, ANN PLAS SURG, V47, P269, DOI 10.1097/00000637-200109000-00009
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NR 27
TC 108
Z9 141
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2005
VL 116
IS 7
BP 1910
EP 1917
DI 10.1097/01.prs.0000189204.71906.c2
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 990SA
UT WOS:000233762300010
PM 16327603
DA 2026-07-24
ER
PT J
AU Van der Velde, M
   Hudson, DA
AF Van der Velde, M
   Hudson, DA
TI VADER (vacuum-assisted dermal recruitment) - A new method of wound
   closure
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE vacuum-assisted wound closure
ID SHOELACE TECHNIQUE; PRESSURE
AB Acute wounds which cannot be closed primarily are usually closed with a split skin graft However a split skin graft has both functional (where tendons are exposed) and esthetic sequelae (contour deformity, different skin in color band texture) A novel technique is described which allows delayed primary closure of either fasciotomy wounds or full-thickness defects after harvest of a free or pedicle flap The technique described combines the boot ace suture technique (which achieves wound closure by progressive suture tightening) with the VAC (vacuum-assisted closure) system (which reduces tissue edema, facilitating movement of tissue, and also reduces bacterial contamination of the wound). Twelve of 14 wounds (average width of wound after insertion and tightening of bootlace suture was 5 cm) were successfully closed after an average of 8 days (range, 4-23 days) in 11 patients (mean age, 45 years; range, 18-77 years) using this technique Of the 2 patients where the technique was not successful, one patient was noncompliant and the other developed wound-edge necrosis Other complications were self-limiting
   The combined use of 2 methods of wound management facilitates delayed primary wound closure.
C1 Univ Cape Town, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
C3 University of Cape Town
RP Hudson, DA (通讯作者)，Groote Schuur Hosp, Observ, H53 Old Main Bldg, ZA-7925 Cape Town, South Africa.
EM hudsond@uctgshi.uct.ac.za
CR Asgari MM, 2000, ANN PLAS SURG, V44, P225, DOI 10.1097/00000637-200044020-00017
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
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   Sawant MR, 2001, INJURY, V32, P619, DOI 10.1016/S0020-1383(01)00035-3
NR 8
TC 15
Z9 27
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2005
VL 55
IS 6
BP 660
EP 664
DI 10.1097/01.sap.0000187181.59748.19
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 991QE
UT WOS:000233827700025
PM 16327471
DA 2026-07-24
ER
PT J
AU Timmers, MS
   Le Cessie, S
   Banwell, P
   Jukema, GN
AF Timmers, MS
   Le Cessie, S
   Banwell, P
   Jukema, GN
TI The effects of varying degrees of pressure delivered by
   negative-pressure wound therapy on skin perfusion
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE vacuum; V A.C; blood flow; wound healing; negative pressure wound
   therapy; NPWT
ID VACUUM-ASSISTED CLOSURE
AB Vacuum-assisted closure (V A C Therapy) uses 2 distinct types of foams, with different physical characteristics: the black polyurethane (PU) foam and the white polyvinyl alcohol (PVA) foam This prospective, randomized study evaluates the response of cutaneous blood flow (CBF) in healthy intact forearm skin to varying V.A.C. Therapy negative pressures and both foam types Continuous negative pressure was used in the range of 25-500 mm Hg. Skin blood flow was measured with noninvasive laser Doppler probes incorporated into the foam. Significant increase in CBF was found with both foams up to negative pressure of 300 mm Hg, with over 5-fold increase (mean 5.57; SD. 3 32) with the PU foam and nearly 3-fold increase (mean: 2.87, SD. 1.29) with the PVA foam. Comparison of blood flow at baseline and at a negative pressure of 300 mm. Hg showed a statistically significant difference (P < 0001) No decrease in blood flow below baseline was observed during the experiments.
C1 Leiden Univ, Med Ctr, Sect Traumatol, Dept Surg, NL-2300 RC Leiden, Netherlands.
   Leiden Univ, Med Ctr, Dept Med Stat, NL-2300 RC Leiden, Netherlands.
   Salisbury Dist Hosp, Odstock Ctr Burns Plast & Reconstruct Surg, Salisbury, Wilts, England.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC; Salisbury District
   Hospital
RP Jukema, GN (通讯作者)，Leiden Univ, Med Ctr, Sect Traumatol, Dept Surg, POB 9600, NL-2300 RC Leiden, Netherlands.
EM G.N.Jukema@lumc.nl
RI le+Cessie, Saskia/HGC-8966-2022
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   Thoma R., 1893, UNTERSUCHUNGEN HISTO, P1
NR 19
TC 210
Z9 256
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2005
VL 55
IS 6
BP 665
EP 671
DI 10.1097/01.sap.0000187182.90907.3d
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 991QE
UT WOS:000233827700026
PM 16327472
DA 2026-07-24
ER
PT J
AU Cowan, KN
   Teague, L
   Sue, SC
   Mahoney, JL
AF Cowan, KN
   Teague, L
   Sue, SC
   Mahoney, JL
TI Vacuum-assisted wound closure of deep sternal infections in high-risk
   patients after cardiac surgery
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID MEDIASTINITIS; STERNOTOMY
AB Background. Sternal wound infections are a serious complication arising from cardiac surgery. Recently, the general application of negative pressure to wounds by vacuum-assisted closure (VAC) therapy has shown enhanced granulation and wound contraction. Here we examine the effect of VAC on sternal wounds.
   Methods. We collected and statistically analyzed quantitative VAC performance data and outcomes with a retrospective review on a consecutive cohort of 22 patients treated with VAC for post-cardiac surgery wound complications.
   Results. Sternal wound infections became evident on average at 21.0 days after surgery, associated with dehiscence (82%), sternal instability (59%), fluid collection by computed tomography (73%), and osteomyelitis (41%). Cultures most commonly identified Staphylococcus auretts (50%). Prompt irrigation and debridement were performed on all patients, and VAC therapy was applied at approximately 7.3 days after diagnosis. Vacuum-assisted closure induced granulation of 71% of the sternal wound area by 7 days, with a daily drainage of approximately 84 mL. By 14 days, there was a 54% reduction in wound size, and patients were discharged after approximately 19.5 days and placed on home therapy. Vacuumassisted closure was discontinued at approximately 36.7 days with an average reduction in sternal wound size of 80%. Extensive secondary surgical closure, requiring muscle flaps, was avoided in 64% of patients, whereas 28% of patients required no surgical reconstruction for wound closure. No complications were related to VAC use.
   Conclusions. In contrast to our earlier studies, adjunctive VAC therapy markedly reduced required surgical interventions, reoperation for persistent infections, and the hospitalization period. Thus, VAC provides a viable and efficacious adjunctive method by which to treat postoperative wound infection after medial sternotomy.
C1 St Michaels Hosp, Div Plast Surg, Toronto, ON M5B 1W8, Canada.
   Univ Toronto, Fac Med, Toronto, ON, Canada.
C3 University of Toronto; Saint Michaels Hospital Toronto; University of
   Toronto
RP Mahoney, JL (通讯作者)，St Michaels Hosp, Div Plast Surg, Room 4-080,30 Bond St, Toronto, ON M5B 1W8, Canada.
EM james.mahoney@utoronto.ca
OI Cowan, Kyle/0000-0003-0109-7716
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bray PW, 1996, CAN J SURG, V39, P297
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NR 14
TC 76
Z9 85
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD DEC
PY 2005
VL 80
IS 6
BP 2205
EP 2212
DI 10.1016/j.athoracsur.2005.04.005
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 993BD
UT WOS:000233926800036
PM 16305872
OA Bronze
DA 2026-07-24
ER
PT J
AU Schintler, M
   Marschitz, I
   Trop, M
AF Schintler, M
   Marschitz, I
   Trop, M
TI The use of topical negative pressure in a paediatric patient with
   extensive burns
SO BURNS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; WOUND CONTROL; THERAPY
C1 Childrens Burns Unit, Dept Paediat, A-8036 Graz, Austria.
   Childrens Burns Unit, Dept Plast Surg, A-8036 Graz, Austria.
RP Trop, M (通讯作者)，Childrens Burns Unit, Dept Paediat, Auenbruggerpl 30, A-8036 Graz, Austria.
EM marija.trop@meduni-graz.at
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P, 2003, P EUR TISS REP SOC L, P73
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NR 16
TC 25
Z9 26
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD DEC
PY 2005
VL 31
IS 8
BP 1050
EP 1053
DI 10.1016/j.burns.2005.03.003
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 993HO
UT WOS:000233945400020
PM 16308100
DA 2026-07-24
ER
PT J
AU Miller, MS
   Lowery, CA
AF Miller, MS
   Lowery, CA
TI Negative pressure wound therapy: "A rose by any other name"
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE negative pressure; VAC; vacuum; Russian
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE
AB Negative pressure wound therapy is one of the dominant adjunctive wound care modalities used in North America. One company has a proprietary hold on the market for this type of wound therapy and recent wound care literature has focused on the company's products rather than on the concept itself Currently utilized standards for negative pressure wound therapy are based on a few relatively recent publications originating after 1997. However, a review of the English and Russian literature that predates this work reveals discrepancies regarding optimal duration of treatment, intensity of negative pressure, mode of application, timing of application, and intervals between treatments. A careful review of research that has rarely been cited in recent wound care literature elucidates the inconsistencies between currently held dogma and less well known negative pressure research. In order to achieve optimal outcomes of care, current practices must be re-evaluated and researched using well-established guidelines for determining treatment safety and effectiveness.
C1 Wound Healing Ctr, Bedford, IN USA.
   Wound Healing Ctr, Linton, IN USA.
   Wound Healing Ctr, Vincennes, IN USA.
   Grandview Med Ctr, Dayton, OH USA.
   Wound Healing Ctr, Terre Haute, IN USA.
RP Miller, MS (通讯作者)，Med Arts Bldg,1024 S 6th St,Suite 103, Terre Haute, IN 47807 USA.
EM doc@docmillers.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Sibbald R Gary, 2003, Ostomy Wound Manage, V49, P52
   Zarogen A., 2001, CHRONIC WOUND CARE C, P117
NR 12
TC 29
Z9 50
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAR
PY 2005
VL 51
IS 3
BP 44
EP +
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 000QS
UT WOS:000234477900006
PM 15984398
DA 2026-07-24
ER
PT J
AU Schwien, T
   Gilbert, J
   Lang, C
AF Schwien, T
   Gilbert, J
   Lang, C
TI Pressure ulcer prevalence and the role of negative pressure wound
   therapy in home health quality outcomes
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE home health; pressure ulcer prevalence; outcomes; negative pressure
   wound therapy
ID CLOSURE
AB Home health agencies, challenged to demonstrate quality while containing costs, are motivated to find best practices for managing patient and wound care. The effects of different wound therapies on frequency of hospitalization and emergent care, two prominent quality measures, have not been studied. A retrospective study was conducted to determine the prevalence of Stage III and Stage IV pressure ulcers in the home health population and to quantify the impact of negative pressure wound therapy in reducing acute care hospitalizations and emergent care in general, and wound infection or deteriorating wound status in particular. Data from 1.94 million OASIS start-of-care assessments in 2003 and 2004 were evaluated to estimate pressure ulcer prevalence and a retrospective matched group analysis compared patients using (n = 60) and not using (n = 2,288) negative pressure wound therapy. In 2003, 6.9% and in 2004, 7% of patients had pressure ulcers at start of care. Of these, 23% were Stage III or Stage IV and 31% were "not healing." In the matched analysis group, it was found that compared to comparison group patients, those receiving negative pressure wound therapy experienced lower rates of hospitalization (35% versus.48%, P < .05), hospitalization due to wound problems (5% versus 14%, P < .01), and emergent care for wound problems (0% versus 8%, P = .01). To offset potential limitations in generalizability and increase practical application of these results, further research is needed with a larger, nationally representative sample to compare other quality outcomes as well as the cost of providing negative pressure wound therapy to other specific wound care modalities.
C1 Outcome Concept Syst Inc, Data Consulting, Seattle, WA 98112 USA.
   Outcome Concept Syst Inc, Data & Prod Serv, Seattle, WA 98112 USA.
RP Schwien, T (通讯作者)，Outcome Concept Syst Inc, Data Consulting, 1818 E Mercer St, Seattle, WA 98112 USA.
EM tinsch@ocsys.com
CR Barak A, 2003, J CAREER ASSESSMENT, V11, P3, DOI 10.1177/106907202237457
   *DEP HLTH HUM SERV, 2002, FIN REP HOM HLTH OUT
   *DEP HLTH HUM SERV, 2005, OUTC BAS QUAL IMPR O
   *DEP HLTH HUM SERV, 2005, OUTC BAS QUAL MON RE
   Department of Health and Human Services Healthcare Financing Administration, 2001, QUAL MON US CAS MIX
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Isago T, 2003, J DERMATOL, V30, P299, DOI 10.1111/j.1346-8138.2003.tb00391.x
   Kinsella Audrey, 2002, Home Healthc Nurse, V20, P457, DOI 10.1097/00004045-200207000-00012
   Kobza L, 2000, Ostomy Wound Manage, V46, P48
   Langemo Diane, 2003, Home Healthc Nurse, V21, P309, DOI 10.1097/00004045-200305000-00007
   Madigan EA, 2003, RES NURS HEALTH, V26, P273, DOI 10.1002/nur.10094
   Metzger Stephanie, 2004, Home Healthc Nurse, V22, P586, DOI 10.1097/00004045-200409000-00003
   Ovington L G, 2001, Home Healthc Nurse, V19, P477, DOI 10.1097/00004045-200108000-00007
   Page Jeffrey C, 2004, Adv Skin Wound Care, V17, P354, DOI 10.1097/00129334-200409000-00015
   Pieper B, 1999, Adv Wound Care, V12, P117
   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
NR 16
TC 55
Z9 65
U1 1
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD SEP
PY 2005
VL 51
IS 9
BP 47
EP +
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 000QZ
UT WOS:000234478700010
PM 16230764
DA 2026-07-24
ER
PT J
AU Norton, SE
   De Souza, B
   Marsh, D
   Moir, G
AF Norton, SE
   De Souza, B
   Marsh, D
   Moir, G
TI Vacuum-assisted closure (VAC therapy) and the risk of fluid loss in
   acute trauma
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE VAC; fluid loss; trauma
C1 Royal London Hosp, Dept Plast Surg, London E1 1BB, England.
C3 Barts Health NHS Trust; Royal London Hospital
RP Norton, SE (通讯作者)，Royal London Hosp, Dept Plast Surg, Whitechapel High St, London E1 1BB, England.
EM samuelnorton@hotmail.com
CR De Souza B, 2003, PLAST RECONSTR SURG, V111, P1370, DOI 10.1097/00006534-200303000-00081
   Friedman T, 2005, ANN PLAS SURG, V55, P420, DOI 10.1097/01.sap.0000174361.52084.6e
   Herscovici D, 2003, J ORTHOP TRAUMA, V17, P683, DOI 10.1097/00005131-200311000-00004
   White RA, 2005, J ORTHOP TRAUMA, V19, P56, DOI 10.1097/00005131-200501000-00011
NR 4
TC 2
Z9 6
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2006
VL 56
IS 2
BP 194
EP 195
DI 10.1097/01.sap.0000194273.56832.ca
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 009HU
UT WOS:000235103300018
PM 16432331
DA 2026-07-24
ER
PT J
AU Varker, KA
   Ng, T
AF Varker, KA
   Ng, T
TI Management of empyema cavity with the vacuum-assisted closure device
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID WOUND CONTROL
AB Management of empyema after pulmonary resection remains a challenging problem. Along with mandatory drainage of the thoracic cavity and investigations to rule out bronchopleural fistula, a reliable method of thoracic cavity closure is needed. The open thoracic window and Eloesser flap techniques rarely represent definitive therapy. Muscle flap and thoracoplasty procedures may provide well-vascularized tissue to close bronchopleural fistula and obliterate the empyema cavity, but they are quite complex and involve significant patient morbidity. We report a case of empyema without bronchopleural fistula after lobectomy in which the vacuum-assisted closure device was used to achieve complete wound healing after open drainage.
C1 Brown Univ, Roger Williams Med Ctr, Dept Surg, Sch Med, Providence, RI 02912 USA.
C3 Brown University; Roger Williams Medical Center
RP Varker, KA (通讯作者)，424 Comprehens Canc Ctr, 410 W 12th Ave, Columbus, OH 43210 USA.
EM varker-1@medctr.osu.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Deslauriers Jean, 2002, Chest Surg Clin N Am, V12, P605, DOI 10.1016/S1052-3359(02)00017-0
   Ferguson AD, 1996, QJM-MON J ASSOC PHYS, V89, P285
   Luckraz H, 2003, J THORAC CARDIOV SUR, V125, P301, DOI 10.1067/mtc.2003.74
   MILLER JI, 2000, GEN THORACIC SURG, P709
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Regnard JF, 2000, J THORAC CARDIOV SUR, V120, P270, DOI 10.1067/mtc.2000.106837
   Vallieres Eric, 2002, Chest Surg Clin N Am, V12, P571, DOI 10.1016/S1052-3359(02)00019-4
NR 8
TC 39
Z9 46
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD FEB
PY 2006
VL 81
IS 2
BP 723
EP 725
DI 10.1016/j.athoracsur.2004.10.040
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 009VV
UT WOS:000235142400053
PM 16427885
DA 2026-07-24
ER
PT J
AU Kilbride, KE
   Cooney, DR
   Custer, MD
AF Kilbride, KE
   Cooney, DR
   Custer, MD
TI Vacuum-assisted closure: a new method for treating patients with giant
   omphalocete
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 36th Annual Meeting of the American-Pediatric-Surgical-Association
CY MAY, 2005
CL Phoenix, AZ
SP Amer Pediat Surg Assoc
DE omphalocele; vacuum-assisted closure; giant omphalocele; wound VAC
ID EXTERNAL COMPRESSION; MANAGEMENT; SILON
AB Introduction: Closure of giant omphalocele can present a surgical challenge. Neither silo, skin flap, nor primary closure has been successful in treating all patients. We present a novel application of the vacuum-assisted closure (VAC) device, which allows for improved results in these difficult cases.
   Methods: The VAC device (KCI, San Antonio, Tex) consisted of a sponge applied directly to the bowel and liver, covered with impermeable transparent dressing, and attached to a low negative pressure system. The sponge was changed every 3 to 5 days under local sedation.
   Patients: All 3 patients had giant omphaloceles. The first infant, a 34 week gestational age (WGA) male, was initially treated with silo reduction, which disrupted after 21 days. The large mass of bowel and liver made primary closure impossible. The VAC was applied for 45 days. The viscera was easily reduced and subsequently covered with acellular dermal matrix (AlloDerm). The VAC was reapplied, and the small remaining defect was skin-grafted. The second male infant was a 34 WGA male infant who became septic after failure of prosthetic mesh closure. The VAC was applied for 22 days after removal of the mesh. The infection resolved, and the defect size was reduced, allowing for skin flap closure. Mesh infection and development of an enterocutaneous fistula in the last patient, a 37 WGA female child, were treated by mesh retrieval and application of the VAC for 36 days. The VAC allowed for control of the fistula output and development of a healthy granulation bed.
   Results: Vacuum-assisted closure was associated with (1) rapid shrinkage and reduction of the viscera (22-45 days); (2) cleansing of the wound; (3) excellent granulation; (4) maintenance of a sterile environment; and (5) ease of use, with changes possible at the bedside.
   Conclusion: The VAC device should be considered a safe and effective alternative in treating complicated cases of giant omphalocele until a more definitive closure method can be used. (c) 2006 Elsevier Inc. All rights reserved.
C1 Texas A&M Univ, Ctr Sci, Dept Surg, Div Pediat Surg, Temple, TX 76508 USA.
C3 Texas A&M University System
RP Custer, MD (通讯作者)，Childrens Hosp Scott & White Hosp, Temple, TX 76502 USA.
CR ALLEN RG, 1969, J PEDIATR SURG, V4, P3, DOI 10.1016/0022-3468(69)90177-8
   Bawazir OA, 2003, J PEDIATR SURG, V38, P725, DOI 10.1016/jpsu.2003.50193
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   Brown MF, 1998, J PEDIATR SURG, V33, P1113, DOI 10.1016/S0022-3468(98)90542-5
   De Ugarte DA, 2004, J PEDIATR SURG, V39, P613, DOI 10.1016/j.jpedsurg.2003.12.022
   GROSS RE, 1948, SURGERY, V24, P277
   HENDRICKSON RJ, 2003, J PEDIATR SURG, V38, P14
   NUCHTERN JG, 1995, J PEDIATR SURG, V30, P771, DOI 10.1016/0022-3468(95)90745-9
   Saxena A, 2002, Hernia, V6, P73
NR 9
TC 50
Z9 61
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 0022-3468
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD JAN
PY 2006
VL 41
IS 1
BP 212
EP 215
DI 10.1016/j.jpedsurg.2005.10.003
PG 4
WC Pediatrics; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 010JZ
UT WOS:000235189400064
PM 16410135
DA 2026-07-24
ER
PT J
AU Labler, L
   Trentz, O
AF Labler, L
   Trentz, O
TI VACTM instillation:: in vitro model.: Part 1
SO BIOMEDIZINISCHE TECHNIK
LA English
DT Article
DE vacuum assisted closure; VAC; VAC instillation; infected wound
AB The reproducibility of a VA.C.(TM) (Vacuum Assisted Closure) instillation system was investigated by means of an in vitro model. The relation between the volume of a delivered solution and its removal from the system was studied in foams of various size. The relationship of instillation time periods and the volume of delivered solution was determined.
C1 Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Labler, L (通讯作者)，Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM ludwig.labler@usz.ch
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Fleischmann W, 1998, UNFALLCHIRURG, V101, P649, DOI 10.1007/s001130050318
   INSTILL VAC, SYSTEM KINETIC CONCE
   Moch D, 1998, Langenbecks Arch Chir Suppl Kongressbd, V115, P1197
NR 4
TC 6
Z9 6
U1 0
U2 0
PU FACHVERLAG SCHIELE SCHON
PI BERLIN
PA MARKGRAFENSTRASSE 11, D-10969 BERLIN, GERMANY
SN 0013-5585
J9 BIOMED TECH
JI Biomed. Tech.
PD DEC
PY 2005
VL 50
IS 12
BP 413
EP 418
DI 10.1515/BMT.2005.058
PG 6
WC Engineering, Biomedical; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Medical Informatics
GA 010LO
UT WOS:000235196400005
PM 16429946
DA 2026-07-24
ER
PT J
AU Heller, L
   Levin, SL
   Butler, CE
AF Heller, L
   Levin, SL
   Butler, CE
TI Management of abdominal wound dehiscence using vacuum assisted closure
   in patients with compromised healing
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE surgical wound dehiscence; wound healing; hernia; surgical mesh;
   surgical flaps; laparotomy; fascia; vacuum; abdomen
ID FASCIAL DEHISCENCE; INCISIONAL HERNIA; TEMPORARY CLOSURE; WALL;
   PREVENTION; OPERATIONS; ABDOMEN; FLUID
AB Background: Restoration of the abdominal wall's integrity after postoperative Wound dehiscence is frequently performed in a delayed fashion, necessitating a temporary dressing of the dehisced wound.
   Methods: The Vacuum Assisted Closure (VAC) system (Kinetic Concepts, Inc., San Antonio, TX) was used in 21 patients with postoperative abdominal wound dehiscences that could not be closed immediately and who were at high risk for healing complications. The VAC device was used in conjunction with sharp debridement and it was maintained on a continuous mode with a negative pressure of -75 to -125 mm Hg. The dressing was changed every 2 days. VAC therapy was continued until the integrity of the abdominal wall was reestablished by surgical procedures or secondary healing,
   Results: Thirteen patients had fascial dehiscence, and 9 of them had frank bowel exposure. Definitive fascial closure was performed in 9 of 13 patients with fascial dehiscence. Stable cutaneous coverage was subsequently achieved in all patients by local abdominal skin flap advancement (6), skin grafting (9), or secondary intention healing (6). Seven patients had part of their VAC therapy as outpatients. The complications included a low-output small bowel enterocutaneous fistula in 2 patients and partial skin graft loss in I patient. The fistulae resolved after operative treatment (1) or conservative treatment (1). Conclusion: Integration of the VAC system in the management of post-laparotomty wound dehiscence in patients with compromised wound healing appears to be successful and should be considered in such patients to provide a stable, healed wound. (c) 2006 Excerpta Medica Inc. All rights reserved.
C1 Univ Texas, MD Anderson Canc Ctr, Dept Plast Surg, Unit 443, Houston, TX 77230 USA.
   Duke Univ, Med Ctr, Dept Plast Surg, Durham, NC USA.
C3 University of Texas System; UTMD Anderson Cancer Center; Duke University
RP Butler, CE (通讯作者)，Univ Texas, MD Anderson Canc Ctr, Dept Plast Surg, Unit 443, POB 301402, Houston, TX 77230 USA.
EM cbutler@mdanderson.org
RI Butler, Charles/GOH-1645-2022
CR AKERS DL, 1991, J VASC SURG, V14, P48
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   EMMONS SL, 1988, OBSTET GYNECOL, V72, P559
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NR 29
TC 79
Z9 94
U1 0
U2 7
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD FEB
PY 2006
VL 191
IS 2
BP 165
EP 172
DI 10.1016/j.amjsurg.2005.09.003
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 010TQ
UT WOS:000235221200005
PM 16442940
DA 2026-07-24
ER
PT J
AU Archdeacon, MT
   Messerschmitt, P
AF Archdeacon, MT
   Messerschmitt, P
TI Modern Papineau technique with vacuum-assisted closure
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE Papineau; bone graft; vacuum-assisted closure; wound; osteomyelitis
ID INFECTED TIBIAL NONUNION; CHRONIC OSTEOMYELITIS; MANAGEMENT; EXCISION;
   THERAPY
AB We describe a contemporary modification of the Papineau technique by implementing a vacuum-assisted closure (V.A.C.(R)) device in lieu of wet-to-dry dressing changes. The method makes use of a protocol similar to that of Papineau and others for the treatment of chronic osteomyelitis. This protocol includes aggressive excisional debridement of infected or necrotic bone, open bone grafting with cancellous autograft, vacuum-assisted wound closure by secondary intent, and eradication of chronic infection with concomitant parenteral antibiotics. A representative case report is included to illustrate the technique.
C1 Univ Cincinnati, Coll Med, Dept Orthopaed Surg, Cincinnati, OH 45267 USA.
C3 University System of Ohio; University of Cincinnati
RP Archdeacon, MT (通讯作者)，Univ Cincinnati, Coll Med, Dept Orthopaed Surg, POB 670212, Cincinnati, OH 45267 USA.
EM michael.archdeacon@uc.edu
OI Archdeacon, Michael/0000-0002-4171-0303
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bucalo Brian, 1993, Wound Repair and Regeneration, V1, P181, DOI 10.1046/j.1524-475X.1993.10308.x
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   EMAMI A, 1995, ACTA ORTHOP SCAND, V66, P447, DOI 10.3109/17453679508995585
   GREEN SA, 1994, CLIN ORTHOP RELAT R, P111
   Herscovici D, 2003, J ORTHOP TRAUMA, V17, P683, DOI 10.1097/00005131-200311000-00004
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NR 12
TC 32
Z9 47
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD FEB
PY 2006
VL 20
IS 2
BP 134
EP 137
DI 10.1097/01.bot.0000184147.82824.7c
PG 4
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 014YI
UT WOS:000235516500009
PM 16462567
DA 2026-07-24
ER
PT J
AU Schuster, R
   Moradzadeh, A
   Waxman, K
AF Schuster, R
   Moradzadeh, A
   Waxman, K
TI The use of vacuum-assisted closure therapy for the treatment of a large
   infected facial wound
SO AMERICAN SURGEON
LA English
DT Article
AB Chronic wounds in difficult locations pose constant challenges to health care providers. Negative-pressure wound therapy is a relatively new treatment to promote wound healing. Laboratory and clinical studies have shown that the vacuum-assisted closure (VAC) therapy increases wound blood flow, granulation tissue formation, and decreases accumulation of fluid and bacteria. VAC therapy has been shown to hasten wound closure and formation of granulation tissue in a variety of settings. Accepted indications for VAC therapy include the infected sternum, open abdomen, chronic, nonhealing extremity wounds and decubitus ulcers. We report the first case of VAC therapy successfully used on a large infected wound to the face to promote healing.
C1 Santa Barbara Cottage Hosp, Dept Surg Educ, Santa Barbara, CA 93102 USA.
   Santa Barbara Cottage Hosp, Dept Surg, Santa Barbara, CA 93102 USA.
C3 Santa Barbara Cottage Hospital; Santa Barbara Cottage Hospital
RP Waxman, K (通讯作者)，Santa Barbara Cottage Hosp, Dept Surg Educ, POB 689, Santa Barbara, CA 93102 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
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   HERSH RE, 1997, ANN PLAST SURG, V38, P563
   HIBBS P, 1989, DECUBITUS, V2, P32
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   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
NR 12
TC 24
Z9 25
U1 0
U2 1
PU SOUTHEASTERN SURGICAL CONGRESS
PI ATLANTA
PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA
SN 0003-1348
J9 AM SURGEON
JI Am. Surg.
PD FEB
PY 2006
VL 72
IS 2
BP 129
EP 131
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 018HP
UT WOS:000235755300006
PM 16536241
DA 2026-07-24
ER
PT J
AU Goverman, J
   Yelon, JA
   Platz, JJ
   Singson, RC
   Turcinovic, M
AF Goverman, J
   Yelon, JA
   Platz, JJ
   Singson, RC
   Turcinovic, M
TI The "Fistula VAC," a technique for management of enterocutaneous
   fistulae arising within the open abdomen: Report of 5 cases
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE intestinal fistulae; open abdominal wounds; vacuum assisted closure
ID ABDOMINAL COMPARTMENT SYNDROME; DAMAGE-CONTROL LAPAROTOMY; ASSISTED
   CLOSURE; PACK TECHNIQUE; TRAUMA; EXPERIENCE
AB Background: Management of intestinal fistulae in open abdominal wounds remains a significant clinical challenge for those caring for patients surviving damage control abdominal operations. Breaking the cycle of tissue inflammation, infection, and sepsis, resulting from leakage of enteric contents, should be a major goal in the approach to these complex patients. We describe a technique utilizing vacuum assisted closure (VAC) which achieves control of enteric flow from fistulae in open abdominal wounds.
   Methods: The fistula-VAC is fashioned from standard sponge supplies, negative pressure pumps, and ostomy appliances. The fistula-VAC was changed every three days prior to split thickness skin grafting, and every five days following grafting.
   Results: Five patients underwent application of the fistula-VAC. All patients had complete diversion of enteric contents. This enteric diversion allowed for successful skin grafting in all patients.
   Conclusion:. Application of the fistula-VAC should be considered a useful option in treating patients with intestinal fistulae in open abdominal wounds.
C1 N Shore Univ Hosp, N Shore Long Isl Jewish Hlth Syst, Manhasset, NY USA.
C3 Northwell Health; North Shore University Hospital
RP Yelon, JA (通讯作者)，New York Med Coll, Munger Pavil, Valhalla, NY 10595 USA.
EM jay_yelon@NYMC.edu
RI Goverman, Jeremy/AAZ-6769-2020
OI Goverman, Jeremy/0000-0001-8717-852X; Yelon, Jay/0000-0001-7980-8042
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
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   Garner GB, 2001, AM J SURG, V182, P630, DOI 10.1016/S0002-9610(01)00786-3
   Girard S, 2002, AM J SURG, V184, P166, DOI 10.1016/S0002-9610(02)00916-9
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   Smith LA, 1997, AM SURGEON, V63, P1102
   Subramaniam MH, 2002, J TRAUMA, V53, P386, DOI 10.1097/00005373-200208000-00037
NR 13
TC 98
Z9 119
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD FEB
PY 2006
VL 60
IS 2
BP 428
EP 431
DI 10.1097/01.ta.0000203588.66012.c4
PG 4
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 018MF
UT WOS:000235767700043
PM 16508512
DA 2026-07-24
ER
PT J
AU Steenvoorde, P
   Rozeboom, AL
   Melief, P
   Kraemer, CV
   Bonsing, BA
AF Steenvoorde, P
   Rozeboom, AL
   Melief, P
   Kraemer, CV
   Bonsing, BA
TI Failure of the topical negative pressure abdominal dressing system in
   the "fat" open abdomen: Report of a case and review of the literature
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SEVERE INTRAABDOMINAL INFECTION; FASCIAL
   CLOSURE; VENTRAL HERNIA; WOUND CLOSURE; THERAPY; LAPAROSTOMY;
   MANAGEMENT; DEVICE
AB An obese patient presented with a Candida albicans ventriculitis and peritonitis after a ventriculo-peritoneal drain became infected. The open abdomen (laparostomy) was treated with a topical negative pressure (TNP) abdominal dressing system. The patient was first treated with an ileocecal resection, which was later complicated by an abdominal compartment syndrome for which a laparostomy was needed. With the TNP abdominal dressing system alone, the abdominal fascia showed extreme retraction. In the literature, several authors propose the combination of sutures with the TNP system in order to approximate wound edges. The herein described combination of the TNP abdominal dressing system with a progressive Bogota bag closure is based on the same principles. Despite aggressive surgical and medical therapy, the patient eventually died of a systemic Pseudomonas infection. The TNP abdominal dressing system alone may not be powerful enough to prevent retraction of the fascia. Combination with progressive Bogota bag closure prevents this but still preserves the essential beneficial effects of the TNP abdominal dressing system.
C1 Rijnland Hosp Leiderdorp, NL-2353 GA Leiderdorp, Netherlands.
   Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands.
   Leiden Univ, Med Ctr, Dept Intens Care, Leiden, Netherlands.
C3 Rijnland Hospital; Leiden University - Excl LUMC; Leiden University;
   Leiden University Medical Center (LUMC); Leiden University - Excl LUMC;
   Leiden University; Leiden University Medical Center (LUMC)
RP Steenvoorde, P (通讯作者)，Rijnland Hosp Leiderdorp, Simon Smitweg 1, NL-2353 GA Leiderdorp, Netherlands.
EM p.steenvoorde@rijnland.nl
RI Elzo Kraemer, Carlos V/HPG-5875-2023
OI Elzo Kraemer, Carlos V/0000-0002-5426-9334
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   BOTTA M, 2004, 2 WORLD UN WOUND HEA
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   Wilson Joyce A, 2004, Adv Skin Wound Care, V17, P426, DOI 10.1097/00129334-200410000-00013
NR 42
TC 4
Z9 11
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2006
VL 18
IS 2
BP 44
EP +
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 018YC
UT WOS:000235799700005
DA 2026-07-24
ER
PT J
AU Gupta, S
AF Gupta, S
TI Guidelines for managing pressure ulcers with negative pressure wound
   therapy
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SEALING-TECHNIQUE; RANDOMIZED-TRIAL; INHIBITOR;
   FLUID; FIBRONECTIN; DEGRADATION; PROMOTE; SYSTEM
AB Pressure ulcers are a serious health issue, leading to clinical, financial, and emotional challenges. Numerous treatment modalities are available to promote wound healing, yet clinicians may be unsure how to incorporate these treatment options into an overall plan of care for the patient with a pressure ulcer. A consensus panel of experienced wound care clinicians convened in July 2004 to review the mechanisms of action and research basis for one such treatment modality: negative pressure wound therapy. After answering key questions about this modality, they developed an algorithm to assist the clinician in making decisions about using negative pressure wound therapy appropriately in patients with Stage III and Stage IV pressure ulcers.
RI Gupta, Subhas/C-5458-2018
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NR 91
TC 1
Z9 1
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JAN-FEB
PY 2005
VL 32
IS 1
BP A2
EP A16
PG 15
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 020DI
UT WOS:000235888200002
DA 2026-07-24
ER
PT J
AU Phelps, JR
   Fagan, R
   Pirela-Cruz, MA
AF Phelps, JR
   Fagan, R
   Pirela-Cruz, MA
TI A case study of negative pressure wound therapy to manage acute
   necrotizing fasciitis
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE necrotizing fasciitis; wound vac; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE
AB Acute necrotizing fasciitis is a devastating infectious process that requires immediate surgical debridement. Intravenous antibiotic treatment, hyperbaric oxygen therapy, and wound management are considered the standard of care. Subsequent wound closure is achieved with split-thickness skin grafting, delayed surgical closure, or healing by secondary intention. When a patient refuses additional surgical treatment or is no longer a surgical candidate, as was the case with a patient who presented with acute necrotizing fasciitis caused by Clostridium perfringens in the upper extremity, secondary intention healing is the only treatment option. Following surgery and intravenous antibiotic treatment, her wounds were managed with topical negative pressure wound therapy. No adverse events occurred and the wounds were almost completely healed 63 weeks following surgery. Research to develop evidence-based protocols of care for the closure of these wounds is needed.
C1 Texas Tech Hlth Sci Ctr, Dept Orthoped Surg, El Paso, TX 79905 USA.
   Texas Tech Hlth Sci Ctr, Dept Orthopaed Surg & Rehabil, El Paso, TX 79905 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center El Paso; Texas Tech University System; Texas Tech University
   Health Sciences Center El Paso
RP Pirela-Cruz, MA (通讯作者)，Texas Tech Hlth Sci Ctr, Dept Orthoped Surg, 4800 Alberta Ave, El Paso, TX 79905 USA.
EM Miguel.Cruz@ttuhsc.edu
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NR 14
TC 14
Z9 21
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAR
PY 2006
VL 52
IS 3
BP 54
EP 59
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 022QQ
UT WOS:000236071200008
PM 16565526
DA 2026-07-24
ER
PT J
AU Senchenkov, A
   Knoetgen, J
   Chrouser, KL
   Nehra, A
AF Senchenkov, A
   Knoetgen, J
   Chrouser, KL
   Nehra, A
TI Application of vacuum-assisted closure dressing in penile skin graft
   reconstruction
SO UROLOGY
LA English
DT Article
AB Introduction. Skin grafting of penile defects is difficult because of the flexibility of the underlying recipient bed. This leads to disruption of the vascular ingrowth into the skin graft and compromises the results of the reconstruction.
   Technical Considerations. We successfully used a vacuum-assisted closure dressing with an incorporated wooden framework to secure penile skin grafts in place during the early postoperative period.
   Conclusions. A vacuum-assisted closure dressing can be used successfully to secure large and circumferential skin grafts, as well as skin grafts on concealed penises.
C1 Mayo Clin, Dept Plast & Reconstruct Surg, Rochester, MN 55905 USA.
   Mayo Clin, Dept Urol, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic
RP Senchenkov, A (通讯作者)，Mayo Clin, Dept Plast & Reconstruct Surg, Mayo bldg W1244,200 1st St SW, Rochester, MN 55905 USA.
EM senchenkov@yahoo.com
CR Black PC, 2004, J UROLOGY, V172, P976, DOI 10.1097/01.ju.0000133972.65501.44
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NR 7
TC 29
Z9 31
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD FEB
PY 2006
VL 67
IS 2
BP 416
EP 419
DI 10.1016/j.urology.2005.08.037
PG 4
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 024EO
UT WOS:000236178500042
PM 16461101
DA 2026-07-24
ER
PT J
AU Steenvoorde, P
   de Roo, RA
   Oskam, J
   Neijenhuis, P
AF Steenvoorde, P
   de Roo, RA
   Oskam, J
   Neijenhuis, P
TI Negative pressure wound therapy to treat peri-prosthetic
   methicillin-resistant Staphylococcus aureus infection after incisional
   herniorrhaphy. A case study and literature review
SO OSTOMY WOUND MANAGEMENT
LA English
DT Review
DE MRSA; infection; vacuum-assisted therapy; prosthetic mesh; incisional
   hernia; laparotomy
ID VACUUM-ASSISTED CLOSURE; DEVICE
AB The preferred treatment for incisional hernias occurring post laparotomy involves use of prosthetic mesh. If this mesh becomes infected, it may have to be removed to achieve wound healing. A patient with a methicillin-resistant Staphylococcus aureus-infected prosthetic mesh received negative pressure wound therapy to help facilitate healing without removing the prosthetic mesh applied to manage his hernia. After almost 4 weeks of treatment, the wound was closed secondarily. The literature contains many case studies about the use of NPWT for a variety of wounds but information about its safety and effectiveness for managing methicillin-resistant Staphylococcus aureus-infected prosthetic mesh is limited. The results of this case study add to the evidence that controlled clinical studies are warranted.
C1 Rijnland Hosp Leiderdorp, Dept Surg, NL-2353 GA Leiderdorp, Netherlands.
C3 Rijnland Hospital
RP Steenvoorde, P (通讯作者)，Rijnland Hosp Leiderdorp, Dept Surg, Simon Smitweg 1, NL-2353 GA Leiderdorp, Netherlands.
EM p.steenvoorde@rijnland.nl
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NR 18
TC 17
Z9 17
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JAN
PY 2006
VL 52
IS 1
BP 52
EP 54
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 025DY
UT WOS:000236246700009
PM 16464991
DA 2026-07-24
ER
PT J
AU Campbell, PE
   Bonham, PA
AF Campbell, PE
   Bonham, PA
TI Surgical wound case studies with the versatile 1 wound vacuum system for
   negative pressure wound therapy
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
ID ASSISTED CLOSURE; MANAGEMENT; DRESSINGS; ULCERS
AB Negative pressure wound therapy consists of a wound dressing, a drainage tube inserted into the dressing, an occlusive transparent film, and a connection to a vacuum source that supplies the negative pressure. A new product called the Versatile 1 Wound Vacuum System (BlueSky Medical, La Costa, Calif) is available for negative pressure wound therapy. This article describes the application, management, and effectiveness of the Versatile 1 in 3 cases where the patients have all undergone surgical debridement.
C1 Avalon Healthcare, Nashville, TN 37211 USA.
   Med Univ S Carolina, Coll Nursing, Wound Care Educ Program, Charleston, SC USA.
C3 Medical University of South Carolina
RP Campbell, PE (通讯作者)，Avalon Healthcare, 5609 Seesaw Rd, Nashville, TN 37211 USA.
EM campvols@comcast.net
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NR 34
TC 18
Z9 36
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAR-APR
PY 2006
VL 33
IS 2
BP 176
EP 190
DI 10.1097/00152192-200603000-00014
PG 15
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 026LU
UT WOS:000236341200010
PM 16572020
DA 2026-07-24
ER
PT J
AU Ullmann, Y
   Fodor, L
   Ramon, Y
   Soudry, M
   Lerner, L
AF Ullmann, Y
   Fodor, L
   Ramon, Y
   Soudry, M
   Lerner, L
TI The revised "reconstructive ladder" and its applications for high-energy
   injuries to the extremities
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE high-energy injuries; reconstructive ladder; acute shortening; VAC
ID VACUUM-ASSISTED CLOSURE; EXTERNAL FIXATION; THERAPY; MANAGEMENT; SYSTEM;
   BONE; WOUNDS; WAR
AB In this report, we tried to evaluate the merits of the classic "reconstructive ladder" and other reconstructive tools, such as acute shortening followed by distraction osteogenesis and a vacuum-assisted closure device, for the treatment of high-energy injuries. Thirty-sevcn patients suffering from high-velocity injuries to the extremities caused by war weapons and blast terror attacks were treated at our institution. The fractures were initially stabilized by the Association for the Study of Internal Fixation (AO/ASIF) unilateral tubular external fixator, which was changed 2-3 days later to a circular Ilizarov frame for 19 patients. Temporary acute shortening was performed for 5 patients. Skin grafts were performed for 21 patients, local or regional flaps for 14 patients, and free flaps for 6. Vacuum-assisted closure was selected for 8 patients. The wounds were successfully closed in all the patients. Two patients with upper-linib injuries had nonunion. Motor nerve injuries recovered in 7/10 patients. Due to hypergranulating tissue, 2 patients treated with vacuum-assisted closure (VAC) had to stop treatment early. Their wounds were closed with skin graft or local flap. The classic reconstructive ladder, starting from direct closure and ending with a free flap, should be extended for limb traumas and include acute shortening with or without angulation, followed by distraction osteogenesis and the VAC system on the same step as the free flap.
C1 Technion Israel Inst Technol, Rambam Med Ctr, Dept Plast & Reconstruct Surg, IL-31096 Haifa, Israel.
   Technion Israel Inst Technol, Rambam Med Ctr, Dept Orthopaed Surg, IL-31096 Haifa, Israel.
   Technion Israel Inst Technol, Fac Med, IL-31096 Haifa, Israel.
C3 Technion Israel Institute of Technology; Rambam Health Care Campus;
   Technion Israel Institute of Technology; Rambam Health Care Campus;
   Technion Israel Institute of Technology; Rappaport Faculty of Medicine
RP Ullmann, Y (通讯作者)，Technion Israel Inst Technol, Rambam Med Ctr, Dept Plast & Reconstruct Surg, 8 Haaliya St, IL-31096 Haifa, Israel.
EM y_ullmann@rambam.health.gov.il
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NR 43
TC 41
Z9 47
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD APR
PY 2006
VL 56
IS 4
BP 401
EP 405
DI 10.1097/01.sap.0000201552.81612.68
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 026XP
UT WOS:000236376900014
PM 16557072
DA 2026-07-24
ER
PT J
AU Greene, AK
   Puder, M
   Roy, R
   Arsenault, D
   Kwei, S
   Moses, MA
   Orgill, DP
AF Greene, AK
   Puder, M
   Roy, R
   Arsenault, D
   Kwei, S
   Moses, MA
   Orgill, DP
TI Microdeformational wound therapy - Effects on angiogenesis and matrix
   metalloproteinases in chronic wounds of 3 debilitated patients
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE microdeformational wound therapy; MDWT; vacuum assisted closure; VAC;
   angiogenesis; matrix metalloprotemases; subatmospheric pressure; wound
   healing
ID VACUUM-ASSISTED CLOSURE; ENDOGENOUS INHIBITORS; GROWTH-CONTROL;
   ANGIOSTATIN; ULCERS; MATRIX-METALLOPROTEINASE-9; EXPRESSION; HYPOXIA;
   MODEL; MICE
AB The vacuum-assisted closure (VAC) device causes microdeformations of the wound Surface in contact with the foam Because angiogenesis and matrix metalloproteinase (MMP) activity are altered in chronic wounds, we hypothesized that microdeformations stimulate capillary formation and affect MMP activity. A VAC device was used to deliver microdeformational Wound therapy (MDWT) to the chronic wounds of 3 debilitated patients. Debrided tissue was obtained from Wound areas with and without foam contact. Microvessel density and MMP activity were determined by immunohistochemistry and zymography, respectively. Microvessel density of MDWT-treated wounds was 4.5% (+/- 0.8) compared with areas not covered by foam [1.6% (+/- 0.1)] (P = 0.05) during the first week of treatment and 2.7% (+/- 0.3) compared With untreated tissue [1.3% (+/- 0.1)] (P = 0.03) during the second treatment week. Wounds subjected to MDWT had greater microvessel density compared with the same wound prior to treatment [1.5% (+/- 0.3)] (P = 0.02). MMP-9/NGAL (neutrophil gelatinase-associated lipocalin), MMP-9, latent MMP-2. and active MMP-2 were reduced by 15%-76% in MDWT-treated wounds. MDWT provides a favorable wound-healing environment by increasing angiogenesis and decreasing MMP activity in chronic wounds.
C1 Harvard Univ, Brigham & Womens Hosp, Div Plast Surg, Harvard Plast Surg Program, Boston, MA 02115 USA.
   Harvard Univ, Childrens Hosp Boston, Dept Surg, Vasc Biol Program, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital
RP Orgill, DP (通讯作者)，Harvard Univ, Brigham & Womens Hosp, Div Plast Surg, Harvard Plast Surg Program, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
FU NCI NIH HHS [CA4558, CA83106] Funding Source: Medline; NIDDK NIH HHS
   [1K08DK069621, DK065298] Funding Source: Medline
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NR 35
TC 189
Z9 221
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD APR
PY 2006
VL 56
IS 4
BP 418
EP 422
DI 10.1097/01.sap.0000202831.43294.02
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 026XP
UT WOS:000236376900018
PM 16557076
DA 2026-07-24
ER
PT J
AU Segers, P
   de Jong, AP
   Kloek, JJ
   Spanjaard, L
   de Mol, BAJM
AF Segers, P
   de Jong, AP
   Kloek, JJ
   Spanjaard, L
   de Mol, BAJM
TI Risk control of surgical site infection after cardiothoracic surgery
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE thoracic surgery; wound infection; risk; surveillance; topical negative
   pressure
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE INFECTIONS; MORTALITY; THERAPY;
   MORBIDITY; IMPACT
AB The purpose of this prospective study was to investigate whether a risk control programme based on risk assessment, new treatment modalities and the presence of a surveillance programme reduces the incidence of surgical, site infections (SSI). Between January 2001 and December 2003, 167 patients were treated for a total of 183 SSIs. Data were collected on pre-operative risk factors, intra-operative data and postoperative recovery, including complications, infecting organisms, SSI treatment techniques and length of hospital stay. In this series, the total incidence of SSI was 5.6%. The mean age of affected patients was 65.1 years with a range of 20-87 years. Mean intensive care and hospital. stay for SSI was 3.6 days and 18.8 days, respectively. Total mortality was 4.8%. Many risk factors were encountered, some of which were associated with a high morbidity. The majority of SSIs were treated by topical. negative pressure therapy (N=81), which gave few side-effects and good clinical. results. After starting the surveillance programme, a steady decline in prevalence was observed from 8.9% to 3.9%. This series adds to the evidence that SSI after cardiothoracic surgery is a major but mainly preventable cause of morbidity and mortality. Risk factor assessment, application of novel treatment modalities and an adequate surveillance system all increased patient safety. (c) 2005 The Hospital. Infection Society. Published by Elsevier Ltd. All rights reserved.
C1 Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, NL-1105 AZ Amsterdam, Netherlands.
   Tech Univ Eindhoven, Dept Biomed Engn, Eindhoven, Netherlands.
   Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Eindhoven
   University of Technology; University of Amsterdam; Academic Medical
   Center Amsterdam
RP Segers, P (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM p.segers@amc.uva.nl
RI ; Segers, Patrick/IWM-4183-2023
OI de Mol, Bastian/0000-0001-6888-9430; 
CR Astagneau P, 2001, J HOSP INFECT, V48, P267, DOI 10.1053/jhin.2001.1003
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NR 24
TC 12
Z9 15
U1 0
U2 2
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD APR
PY 2006
VL 62
IS 4
BP 437
EP 445
DI 10.1016/j.jhin.2005.09.028
PG 9
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 029II
UT WOS:000236555400006
PM 16455163
DA 2026-07-24
ER
PT J
AU Gustafsson, R
   Sjögren, J
   Malmsjö, M
   Wackenfors, A
   Algotsson, L
   Ingemansson, R
AF Gustafsson, R
   Sjögren, J
   Malmsjö, M
   Wackenfors, A
   Algotsson, L
   Ingemansson, R
TI Vacuum-assisted closure of the sternotomy wound: Respiratory mechanics
   and ventilation
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID CARDIAC-SURGERY; STERNAL WOUNDS; MEDIASTINITIS; INFECTIONS; PRESSURE;
   THERAPY; COMPLICATIONS; EXPERIENCE; SYSTEM
AB Background: Numerous authors have reported promising results with the use of vacuum-assisted closure therapy in poststernotomy mediastinitis. The negative pressure applied to the anterior mediastinum substantially exceeds the normal negative pressure in the pleural cavities, and interaction with respiratory physiology cannot be excluded. The aim of the present study was to evaluate whether the application of six clinically relevant negative pressures between -50 mmHg and -175 mmHg to the sternotomy wound affects respiratory parameters in a porcine model.
   Methods: A midline sternotomy was performed in six mechanically ventilated pigs weighing 70 +/- 3 kg. Vacuum-assisted closure therapy was applied with continuous negative pressure in a randomized order to the sternotomy wound. The following respiratory parameters were monitored by a carbon dioxide-based noninvasive monitoring system connected to the ventilator: carbon dioxide elimination, peak inspiratory pressure, peak expiratory flow, alveolar minute volume, alveolar tidal volume, expired tidal volume, static compliance, and airway resistance.
   Results: All pigs survived the treatment, and there was no significant change in the respiratory parameters investigated at any of the six negative pressures applied. A tendency toward increased airway resistance was noted when -175 mmHg was applied, although this change was not significant.
   Conclusions: The application of negative pressure therapy in the treatment of deep poststernotomy infections is a novel modality gaming increased attention. In this Study, no impairment in respiratory mechanics, ventilation, or oxygenation was detected when comparing applied pressures ranging from -50 mmHg to -175 mmHg in the sternotomy wound.
C1 Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Anesthesia, SE-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Internal Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Gustafsson, R (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM ronny.gustafsson@thorax.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599; 
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NR 36
TC 13
Z9 16
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR 1
PY 2006
VL 117
IS 4
BP 1167
EP 1176
DI 10.1097/01.prs.0000200620.77353.40
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 031IK
UT WOS:000236697800015
PM 16582783
DA 2026-07-24
ER
PT J
AU Parrett, BM
   Matros, E
   Pribaz, JJ
   Orgill, DP
AF Parrett, BM
   Matros, E
   Pribaz, JJ
   Orgill, DP
TI Lower extremity trauma: Trends in the management of soft-tissue
   reconstruction of open tibia-fibula fractures
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 21st Annual Meeting of the
   American-Society-for-Reconstructive-Microsurgery
CY JAN 15-18, 2005
CL Fajardo, PR
SP Amer Soc Reconstruct Microsurg
ID ISLAND FLAP; EXPERIENCE; EVOLUTION; COVERAGE; DEFECTS; THERAPY; ANKLE
AB Background: Open lower leg fractures With exposed bone or tendon continue to be challenging for plastic surgeons. Microvascular free-tissue transfer increases the ability to close wounds, transfer vascularized bone, and prevent amputation, yet remains a complex, invasive procedure with significant complication rates, donor-site morbidity, and failure rates. This review documents the changing treatment protocol in the authors' institution for these injuries.
   Methods: Two hundred ninety consecutive open tibia-fibula fractures over a 12-year period (1992 to 2003) were retrospectively reviewed and methods and outcomes were compared by grouping the fractures into 4-year intervals.
   Results: The number of open lower extremity fractures increased, whereas the distribution of Gustilo grade I to III fractures remained unchanged. Overall, free-tissue transfer was performed less frequently and constituted 20 percent of reconstructions in period 1 (1992 to 1995), 11 percent in period 2 (1996 to 1999), and 5 percent in period 3 (2000 to 2003). For the most severe fractures, Gustilo grade III, free-flap reconstruction has decreased significantly, constituting 42 percent, 26 percent, and 11 percent of procedures in periods 1, 2, and 3, respectively. Local flaps for grade III fractures have remained relatively constant throughout the study. In contrast, local wound care for grade III fractures, including skin grafts, delayed primary closures, and secondary intention closures has significantly increased from 22 percent to 49 percent of reconstructions from periods 1 through 3. In 1997, the authors began to use the vacuum-assisted closure device and now use it in nearly half of all open fractures. Despite this trend, there has been no change in infection, amputation, or malunion/nonunion rates and a decrease in reoperation rate with at least 1-year follow-up.
   Conclusions: These results demonstrate a change in practice, with a trend down the reconstructive ladder, currently using fewer free flaps and more delayed closures and skin grafts with frequent use of the vacuum-assisted closure sponge. Possible reasons for this change are a better understanding of lower leg vascular anatomy and better use of improved Wound care technology.
C1 Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast & Reconstruct Surg, Boston, MA 02478 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Parrett, BM (通讯作者)，Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast & Reconstruct Surg, 75 Francis St, Boston, MA 02478 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
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NR 42
TC 238
Z9 290
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR 1
PY 2006
VL 117
IS 4
BP 1315
EP 1322
DI 10.1097/01.prs.0000204959.18136.36
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 031IK
UT WOS:000236697800038
PM 16582806
DA 2026-07-24
ER
PT J
AU Kneser, U
   Leffler, M
   Bach, AD
   Kopp, J
   Horch, RE
AF Kneser, U
   Leffler, M
   Bach, AD
   Kopp, J
   Horch, RE
TI Vacuum Assisted Closure (VAC®) therapy is an essential tool for
   treatment of complex defect injuries of the upper extremity
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
ID FASCIOTOMY; TRAUMA
AB Introduction: Complex injuries of the upper extremity remain a therapeutic challenge. The prognosis of the damaged extremity is often limited by soft tissue defects. Vacuum Assisted Closure (V.A.C.(R)) therapy facilitates temporary coverage of soft tissue defects prior to surgical reconstruction. Methods: In a retrospective study all patients with complex defect injuries of the upper extremity that were treated by V.A.C.(R) prior to reconstruction between August 2003 and September 2005 were analyzed. Results: 7 patients (6 male, 1 female, 14-70 years) were included in the study. The patients suffered from subtotal upper arm (n = 1) and forearm (n = 1) amputation, complex multilevel amputation injury of the forearm (n = 1), slash wound of the forearm with skin defect and discontinuity of all volar structures (n = 1), complex open forearm fractures with skin and soft tissue defects (n = 2), and almost complete necrosis of the flexor compartment following distal radius and proximal ulnar fracture and compartment syndrome (n = 1). Stabile defect coverage was achieved in all patients following V.A.C.(R) therapy by myocutaneous free flaps (n = 2), split thickness skin grafts (STSG) (n = 2), sequential secondary suture (n = 1), and STSG + secondary suture (n = 2). Wound conditions improved significantly under V.A.C.(R) therapy. 5 patients reported pain relief following induction of V.A.C.(R) therapy. Due to reduction of tissue oedema secondary suture was facilitated in 3 patients. Discussion: V.A.C.(R) therapy represents an essential tool for treatment of complex injuries of the upper extremity with extended soft tissue defects. Decreased frequency of dressing changes as well as reduced tissue oedema considerably improved patient's comfort. Posttraumatic compartment syndrome or skin necrosis, which are often associated with macro amputations of the upper extremity, are efficiently treated with V.A.C.(R), and secondary sutures may be performed despite initial skin defects.
C1 Univ Klinikum Erlangen, Chirurg Univ Klin, Abt Plast & Handchirurg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Kneser, U (通讯作者)，Univ Klinikum Erlangen, Chirurg Univ Klin, Abt Plast & Handchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM ulrich.kneser@chir.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
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NR 17
TC 20
Z9 20
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S7
EP S12
DI 10.1055/s-2006-921470
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100003
PM 16575636
DA 2026-07-24
ER
PT J
AU Leffler, M
   Kneser, U
   Bach, AD
   Kopp, J
   Horch, RE
AF Leffler, M
   Kneser, U
   Bach, AD
   Kopp, J
   Horch, RE
TI Vacuum-assisted closure (VAC®) of disastrous wound conditions in
   Madelung disease
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE vacuum therapy; wound healing disorder; Madelung disease; Launois
   Bensaude syndrome; benign lipomatosis
ID LAUNOIS-BENSAUDE-SYNDROME; LIPOMATOSIS
AB Introduction: A 54 year old patient presented with a Madelung disease. Symmetrically fatty deposits were present on both upper arms, at the abdomen and both thighs. Dermatitis was seen in the axillary fold at the skin bearing surfaces. Shoulder movement was impaired. Liposuction of both upper arms has already been performed, but no significant improvement was obtained. Methods and results: We performed a dermolipectomy of both upper arms. Postoperatively the patient suffered from a severe wound dehiscence with fulminant wound infection and septic clinical condition. Because of the large wound surface (1/3 of the upper arm circumference) anemia occurred and had to be treated with blood transfusions. Wound exsudation caused a general hypoproteinemia. Multiple surgical debridements were necessary in order to clean the wound from necrotic tissue and afterwards moist dressings were applied. Furthermore the patient received intravenous antibiotic treatment. After stabilisation of the general condition of the patient and the wound situation a poly-vinyle sponge and a vacuum-sealing were applied and continuous suction was performed (125 mm Hg). This resulted in a significant improvement of the wound situation in regards to wound cleaning, induction of granulation tissue, wound size diminishment, reduction of oedema and pain reduction. After four weeks of vacuum therapy defect coverage was possible and split thickness skin grafting was performed. The skin graft the vacuum dressing on the fifth day the skin graft has completely healed. Discussion: Vacuum therapy is suitable for disastrous wound conditions in order to achieve a defect size reduction, pain reduction and create a clean wound with granulation tissue for further surgical defect coverage using skin grafts or flaps.
C1 Univ Klinikum Erlangen Nurnberg, Chirurg Univ Klin, Abt Plast & Handchirurg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Klinikum Erlangen Nurnberg, Chirurg Univ Klin, Abt Plast & Handchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@chir.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 14
TC 3
Z9 4
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S15
EP S18
DI 10.1055/s-2006-921473
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100005
PM 16575638
DA 2026-07-24
ER
PT J
AU Reichert, B
AF Reichert, B
TI Optimizing delayed reconstruction of complex pressure sores by VAC®
   therapy
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
DE decubitus ulcer; pressure sore; vacuum assisted closure
ID ULCER RISK-FACTORS; DECUBITUS ULCERS; MYOCUTANEOUS FLAPS; MANAGEMENT;
   COVERAGE; SURGERY; CLOSURE; TRIAL
AB V.A.C.(R)-therapy has improved the treatment of extended pressure sores, because of its beneficial effect on the wound surface and the safe microbial barrier. Definitive reconstructive surgery can be performed earlier. Using modern aids fixation of the device will be possible even in difficult locations as the perianal area. This is important for immobile and multimorbid patients. On the other hand, this area still shows limitations of the method. In recurrent cases it is difficult to use classical methods of reconstruction. Long-term-treatment is necessary, which is economically difficult. It is important for hospitals to cooperate with specialised wound therapeutics so that these patients can be dismissed earlier. This may allow reconstructive procedures, even if this takes several hospital stays over a long period of time.
C1 Klinikum Nurnberg Sud, Zentrum Schwerbrandverletzte, Klin Plast Wiederherstellende & Handchirurg, D-90471 Nurnberg, Germany.
RP Reichert, B (通讯作者)，Klinikum Nurnberg Sud, Zentrum Schwerbrandverletzte, Klin Plast Wiederherstellende & Handchirurg, Breslauer Str 201, D-90471 Nurnberg, Germany.
EM bert.reichert@klinikum-nuernberg.de
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NR 20
TC 1
Z9 1
U1 0
U2 2
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S24
EP S28
DI 10.1055/s-2006-921448
PG 5
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100007
PM 16575640
DA 2026-07-24
ER
PT J
AU Seyhan, H
   Kopp, J
   Polykandriotis, E
   Horch, RE
AF Seyhan, H
   Kopp, J
   Polykandriotis, E
   Horch, RE
TI Vacuum-assisted closure as temporary coverage in the "problem zone hand"
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE vacuum therapy; wound closure; reversed cross finger flap
AB Introduction: Vacuum therapy of hand defect problematic due to the interdigital folds and in particular due to the small surface. As a temporary cover in staged procedures, e.g. following excision of tumor-suspicious skin alterations at the hand, and/or at the fingers, the application of vacuum therapy results not only in a sterile, temporary cover of the wound, furthermore it promotes wound conditioning and reduction of the wound area as well as lymph and edema reduction. Patients and Methods: A 75 year old female patient presented herself with a skin alteration at the right dorsal ring finger and the tentative diagnosis of a Morbus Bowen like lesion was raised. Due to the unclear histological status, a staged procedure with excision of the tumour and temporary defect coverage by means of vacuum therapy until final histological evaluation was indicated. We accomplished the radical excision of the unclear skin tumour at the proximal phalanx under preservation of the synovial sheath of the tendon. Subsequently, the wound was temporarily closed with vacuum therapy. Histological examination revealed the complete removal of a solar keratosis. Finally, after 7 days of vacuum therapy as a sterile dressing, with obvious reduction of wound area and simultaneous decrease of edema, the defect was finally covered with a reversed cross finger flap from the adjacent middle finger. The donor site was covered with a full thickness skin graft harvested from the right forearm. The further course was without complication after flap dissection and complete healing. Discussion: Vacuum therapy represents a useful procedure for temporary wound coverage. Especially at hand defects, when nerves, tendons or bones following trauma or staged procedures are exposed, vacuum therapy can be successfully applied utilizing the special surgical "hand glove" technique.
C1 Univ Klinikum Erlangen Nurnberg, Abt Plast & Handchirurg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Klinikum Erlangen Nurnberg, Abt Plast & Handchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@chir.imed.uni-erlangen.de
RI ; Horch, Raymund E/H-8128-2019
OI Polykaniotis, Elias/0000-0002-8152-6420; Horch, Raymund
   E/0000-0002-6561-2353
CR Horch RE, 2004, ZBL CHIR, V129, pS2, DOI 10.1055/s-2004-822644
   Kneser U, 2005, PLAST RECONSTR SURG, V116, P1910, DOI 10.1097/01.prs.0000189204.71906.c2
   Kopp J, 2005, STRAHLENTHER ONKOL, V181, P124, DOI 10.1007/s00066-005-1291-0
   KOPP J, 2004, ZENTRALBL CHIR S1, V129, P82
NR 4
TC 6
Z9 6
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S33
EP S35
DI 10.1055/s-2006-921436
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100009
PM 16575642
DA 2026-07-24
ER
PT J
AU Horch, RE
AF Horch, RE
TI Changing paradigms in reconstructive surgery by vacuum therapy?
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE changing paradigms; reconstructive surgery; vacuum therapy
ID ASSISTED CLOSURE THERAPY; NEGATIVE-PRESSURE DRESSINGS; BURN WOUND
   PROGRESSION; SUBATMOSPHERIC PRESSURE; STERNAL WOUNDS; SOFT-TISSUE; OPEN
   ABDOMEN; DEFINITIVE CLOSURE; SUCTION DRAINAGE; FASCIAL CLOSURE
AB In modern science the changes of scientific paradigm occur constantly and often unnoticed. Effects of new therapy procedures that are not compatible with the prevailing doctrines first lead to contradictory discussions and may then lead to new doctrines depending upon the general perception. Continuous computer-assisted local negative pressure therapy (vacuum assisted closure therapy/V.A.C.(R), topical negative pressure treatment) has led to unexpected and impressing clinical results since its introduction. This has provoked a recognizable change of different therapeutic concepts in reconstructive surgery. Based on a selection of important clinical examples from reconstructive surgery following a current literature research the attempt is undertaken to point out recognizable changes of paradigms within the treatment algorithms that can be discerned after the the introduction of vacuum therapy in recent years.
C1 Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Abt Plast & Handchirurg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Abt Plast & Handchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@chir.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
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NR 77
TC 13
Z9 13
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S44
EP S49
DI 10.1055/s-2006-921462
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100012
PM 16575645
DA 2026-07-24
ER
PT J
AU Willy, C
   von Thun-Hohenstein, H
   von Lübken, F
   Weymouth, M
   Kossmann, T
   Engelhardt, M
AF Willy, C
   von Thun-Hohenstein, H
   von Lübken, F
   Weymouth, M
   Kossmann, T
   Engelhardt, M
TI Experimental principles of the VAC®-therapy -: Pressure values in
   superficial soft ttissue and the applied foam
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
ID VACUUM-ASSISTED CLOSURE; WOUNDS; DRESSINGS
AB Object of the study: Measurement of the pressure during V.A.C.(R)-therapy in superficial parts of the affected soft tissue as well as at the soft tissue/foam-interface, measurement of pressure values along bigger distances in the foam and the comparison of pressure transfer between polyurethane and polyvinyl-alcohol foams. Material and Methods: A multi-channel electronic transducer-tipped catheter system based on the piezoresistive principle was used. Measurement was performed on a plain table surface, at a bovine muscle as well as in human tibial anterior muscle of a patient after fasciotomy. Applied pressure values by V.A.C.(R)-therapy-units were 50 to 200 mmHg (continuous suction modus). Results: 100% pressure transition through vacuum-therapy-foams to wound surface, almost 100% pressure transition even along 60 cm in very large polyurethan-foams using only one trac-pad connector. Pressure values >125 mm Hg using polyvinyl-alcohol-foams showed a reduction of up to 25% in distances >15 cm from trac-pad-connector. On the surface of the affected soft tissue there are negative and positive pressure values (25% quartile: -25 mm Hg; 75% quartile: + 15 mm Hg). Discussion: Pore walls of the foam can produce positive pressure conditions resulting in soft tissue compression and consecutively hypoperfusion or ischemia. V.A.C.(R)-therapy seems to produce an heterogeneity of pressure distribution at the wound ground leading to pressure gradients and facilitating drainage of interstitial fluid. This mechanism could explain the anti-edema effects of V.A.C.(R)-therapy resulting indirectly in an increased nutritive perfusion.
C1 Bundeswehrkrankenhaus Ulm, Chirurg Klin, D-89081 Ulm, Germany.
   Bundeswehrkrankenhaus Ulm, Urol Abt, Ulm, Germany.
   Alfred Hosp, Ctr Trauma, Melbourne, Vic, Australia.
C3 Ulm University; Military Hospital Ulm; Ulm University; Military Hospital
   Ulm; Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Ulm, Chirurg Klin, Oberer Eselsberg 40, D-89081 Ulm, Germany.
EM pddrmedchristianwilly@bundeswehr.org
RI /AAJ-3174-2021
CR Isago T, 2003, J DERMATOL, V30, P596, DOI 10.1111/j.1346-8138.2003.tb00441.x
   Isago T, 2003, J DERMATOL, V30, P299, DOI 10.1111/j.1346-8138.2003.tb00391.x
   Maier D, 2000, ZBL CHIR, V125, P82
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
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NR 7
TC 16
Z9 18
U1 0
U2 2
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S50
EP S61
DI 10.1055/s-2006-921421
PG 12
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100013
PM 16575646
DA 2026-07-24
ER
PT J
AU Labler, L
   Mica, L
   Härter, L
   Trentz, O
   Keel, M
AF Labler, L
   Mica, L
   Härter, L
   Trentz, O
   Keel, M
TI Influence of VAC®-therapy on cyotokines and growth factors in traumatic
   wounds
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE vacuum assisted closure; VAC (R); trauma; IL-6, IL-8; VEGF; soft tissue
   injury
ID VACUUM-ASSISTED CLOSURE; CARDIAC MYOCYTES; CHEMOKINES; TISSUE;
   EXPRESSION; OXYGEN; VEGF; INTERLEUKIN-10; ANGIOGENESIS; MACROPHAGES
AB Objective: Clinical observations have shown an accelerated woundhealing in wounds of patients treated by Vacuum Assisted Closure (V.A.C.(R))-therapy. The mechanisms of improved wound healing on cellulary level have been hitherto less investigated. In this study the levels of proinflammatory interleukins (IL-6, IL-8, IL-10) and growth factors (VEGF, FGF-2) in serum and wound were monitored. Methods: The study included 21 patients with traumatic wounds that could not be closed during the first surgical intervention. The soft tissue defects (n = 21) were closed temporarily by Epigard(R). During the first second-look operation after 2.0 +/- 0.2 days in an average, Epigard(R) was used for another 2.5 +/- 0.4 days as temporary soft tissue coverage in 13 patients (group A). In the remaining 8 patients the wound conditioning was done by V.A.C.(R) for 2.4 +/- 0.3 days (group B). A total of 428 samples of serum and wound fluid samples were collected during the first and second look operation. Levels of IL-6, IL-8, IL-10, VEGF and FGF were measured specific by ELISA. Results: In all interleukins and growth factors there were significant lower serum level concentrations compared with those in wound fluids. During the first temporary dressing change after wound coverage with Epigard(R) the wound samples showed the following levels [Mean (SEM)]: IL-6 49816 (19889) pg/ml, IL-8 54 (16) ng/ml, IL-10 314 (44) pg/ml, VEGF 4746 (766) pg/ml, FGF-2 494 (89) pg/ml. During the second dressing changes we monitored the following levels in group A: IL-6 7 218 (2 542) pg/ml, IL-8 69 (27) ng/ml, IL-10 261 (58) pg/ml, VEGF 3 551 (661) pg/ml, FGF-2 355 (67) pg/ml. In group B the samples of the wound fluid showed the following results: IL-6 16966 (4124) pg/ml [p=0.02], IL-8 223 (91) ng/ml [p=0.03], IL-10 233 (76) pg/ml [p = 0.38], VEGF 7490 (1565) pg/ml [p = 0.01], FGF-2 352 (43) pg/ml [p = 0.48]. Conclusion: The increased local release of IL-6, IL-8 and VEGF in wounds after V.A.C.(R)-therapy may be involved in the accumulation of neutrophil granulocytes and angiogenesis, which seams to play a crucial role for the accelerated granulation tissue formation after V.A.C.(R)-therapy compared to wounds treated by Epigard(R).
C1 Univ Zurich Hosp, Dept Chirurg, Unfallchirurg Klin, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Labler, L (通讯作者)，Univ Zurich Hosp, Dept Chirurg, Unfallchirurg Klin, Ramistr 100, CH-8091 Zurich, Switzerland.
EM ludwig.labler@usz.ch
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NR 50
TC 28
Z9 34
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S62
EP S67
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100014
PM 16575647
DA 2026-07-24
ER
PT J
AU Wetzel-Roth, W
AF Wetzel-Roth, W
TI 1-year follow-up results on outpatient VAC®-Therapy treatment -
   Evaluation of patient-data
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL
C1 Stadt Krankenhaus Schwabmunchen, Tagesklin, Munich, Germany.
RP Wetzel-Roth, W (通讯作者)，Hindenburgstr 1, D-86807 Buchloe, Germany.
EM info@wetzel-roth.de
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   COERPER S, 2001, AUSWERTUNG BISHERIGE
   Fleischmann W, 1992, Acta Orthop Belg, V58 Suppl 1, P227
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Horch R E, 2005, MMW Fortschr Med, V147 Suppl 1, P1
   Horch RE, 2003, EUR SURG, V35, P5
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Rexer M, 2004, ZBL CHIR, V129, pS27, DOI 10.1055/s-2004-822640
   Walgenbach KJ, 2000, Z FLUGWISS WELTRAUM, V13, P9
   Wetzel-Roth W, 2004, ZBL CHIR, V129, pS7, DOI 10.1055/s-2004-822677
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   WILD T, 2003, EUR SURG S191, V35, P43
   WILLY C, 2005, VAKUUMTHERAPIE
NR 16
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S68
EP S71
DI 10.1055/s-2006-921515
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100015
PM 16575648
DA 2026-07-24
ER
PT J
AU Hofmann, P
   Friess, P
   Findeisen, M
   Tomcik, P
AF Hofmann, P
   Friess, P
   Findeisen, M
   Tomcik, P
TI Case report of successful therapy of necrotizing fasciitis using a
   device of vacuum assisted closure
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
DE vacuum assisted; wound closure; necrotizing fasciitis; soft tissue
   infection
AB Successful wound management is reported in a case of extended and life threatening necrotizing fasciitis of the leg of a polymorbid older woman by use of standards of septic surgery (sufficient excision of necrotic tissue, use of bacteria adapted antibiotics, programmed wound revisions) and use of an industrial supplied device of vacuum assisted closure (V.A.C.(R)).
C1 Kliniken Dr Drogula GmbH, D-96465 Neustadt, Germany.
RP Hofmann, P (通讯作者)，Kliniken Dr Drogula GmbH, Seilersgrundchen 8, D-96465 Neustadt, Germany.
EM hofmannp@krankenhaus-neustadt.de
NR 0
TC 3
Z9 3
U1 0
U2 0
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S72
EP S74
DI 10.1055/s-2006-921475
PG 3
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100016
PM 16575649
DA 2026-07-24
ER
PT J
AU Anagnostakos, K
   Kelm, J
   Schmitt, E
AF Anagnostakos, K
   Kelm, J
   Schmitt, E
TI Indications for use of the VAC®-system in the orthopedic surgery
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE infection; VAC (R)-therapy; hardware preservation
ID VACUUM-ASSISTED CLOSURE; FLAP; THERAPY; MUSCLE; WOUNDS; ACHILLES;
   DEVICE; RECONSTRUCTION; OSTEOMYELITIS; ARTHROPLASTY
AB Introduction: The vacuum-assisted closure (V.A.C.(R))-therapy is accepted for an efficient option in the treatment of infected wounds with healing complications. However, reports on its use in the septic orthopedic surgery are seldom. Hence, the aim of this study is to demonstrate our experience with the V.A.C.(R)-system in the treatment of orthopedic-related infections. Patients-Methods: Various musculoskeletal infections with prolonged wound healing (infections after Achilles tendon reconstruction, fibula osteosynthesis, dorsal spondylodesis, and total hip arthroplasty, skin necrosis after total knee arthroplasty and wound dehiscence after resection and irradiation of a liposarcoma) have been treated with the V.A.C.(R)-device. After infection sanitation we performed skin graft transplantation in 3 cases for definitive wound closure, also assisted by the V.A.C.(R)-therapy. Results: An infection eradication with implant preservation, where necessary, could have been achieved in all cases. No complications were observed in the cases with the skin graft transplantations. No infection persistence or reinfection occurred at a mean follow-up of 36 months. Discussion: The V.A.C.(R)-therapy seems to be a valuable adjunct in the treatment of infected wounds in the orthopedic surgery, however, definitive conclusion should await the results of future clinical studies with large series.
C1 Univ Klinikum Saarlandes, Klin Orthopadie & Orthopad Chirurg, D-66421 Homburg, Germany.
C3 Universitatsklinikum des Saarlandes
RP Anagnostakos, K (通讯作者)，Univ Klinikum Saarlandes, Klin Orthopadie & Orthopad Chirurg, Kirrbergerstr 1, D-66421 Homburg, Germany.
EM konstantinos.anagnostakos@uniklinik-saarland.de
RI Anagnostakos, Konstantinos/MGC-8753-2025
CR ADAM RF, 1994, J BONE JOINT SURG BR, V76B, P750, DOI 10.1302/0301-620X.76B5.8083264
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BROENG L, 1989, UGESKRIFT LAEGER, V153, P2433
   Carls J, 1996, ARTHROSKOPIE, V9, P274
   CHANDRASEKHAR B, 1993, ORTHOP CLIN N AM, V24, P523
   Dalton GP, 2001, CLIN ORTHOP RELAT R, P133
   Dill-Müller D, 2004, ZBL CHIR, V129, pS108, DOI 10.1055/s-2004-822670
   Doss M, 2002, EUR J CARDIO-THORAC, V22, P934, DOI 10.1016/S1010-7940(02)00594-8
   Fleischmann W, 1996, UNFALLCHIRURG, V99, P970, DOI 10.1007/s001130050082
   Fleischmann W, 1996, UNFALLCHIRURG, V99, P283
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   Hochberg J, 1998, PLAST RECONSTR SURG, V102, P385, DOI 10.1097/00006534-199808000-00013
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   Pajala A, 2002, J BONE JOINT SURG AM, V84A, P2016, DOI 10.2106/00004623-200211000-00017
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   Scholl L, 2004, J CARDIAC SURG, V19, P453, DOI 10.1111/j.0886-0440.2004.05002.x
   Shvartsman HS, 2003, OBSTET GYNECOL, V102, P1163, DOI 10.1016/S0029-7844(03)00716-6
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NR 30
TC 4
Z9 5
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S87
EP S92
DI 10.1055/s-2006-921514
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100020
PM 16575653
DA 2026-07-24
ER
PT J
AU Becker, R
   Szöke, N
   Gottstein, J
AF Becker, R
   Szöke, N
   Gottstein, J
TI Wound management of the deep wound infection after complex dorsoventral
   spinal column fusion L3 to S1 under application of the vacuum assisted
   closure
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
DE vacuum assisted closure; dorsoventral spondylodesis; wound management;
   ambulant vacuum therapy; patient compliance
C1 Eduardus Krankenhaus Koln Deutz, Orthopad Klin, D-50679 Cologne, Germany.
RP Becker, R (通讯作者)，Eduardus Krankenhaus Koln Deutz, Orthopad Klin, Custodisstr 3-17, D-50679 Cologne, Germany.
EM dr_rolf.becker@arcor.de
NR 0
TC 2
Z9 2
U1 0
U2 0
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S93
EP S95
DI 10.1055/s-2006-921456
PG 3
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100021
PM 16575654
DA 2026-07-24
ER
PT J
AU Kelm, J
   Schmitt, E
   Anagnostakos, K
AF Kelm, J
   Schmitt, E
   Anagnostakos, K
TI VAC®-therapy: A treatment option for wound healing complications after
   Achilles tendon reconstruction
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE Achilles tendon; wound healing complications; VAC (R)-therapy
ID VACUUM-ASSISTED CLOSURE; PRESSURE; THERAPY
AB Introduction: The postoperative course after Achilles tendon reconstruction is associated with a high incidence rate of infections and wound healing complications, which can lead to protracted healing process and, hence, limit the clinical outcome. Patient-Methods: A 66-year-old male was referred to our clinic with an Achilles tendon rupture. MRI confirmed the diagnosis, an augmented tenoplasty was performed for tendon reconstruction. 11 weeks after surgery the patient presented himself again with an open wound and local infection signs. Results: The surgical treatment included debridement and jet lavage. The V.A.C.(R)-device with the white polyvinyl sponge at an initial pressure of 200 mm Hg was used. A pathogen organism could not be identified. For infection eradication a broad spectrum systemic antibiosis (cefuroxime and gentamicin) was applicated. On 3., 6. and 14. day the dressings were changed and the wound was revised under progredient closure. At beginning formation of granulation tissue the pressure was reduced to 150-100 mmHg. At decreasing blood inflammation parameters and amelioration of the local wound condition the patient could check out after 3 weeks hospitalization. After further successful ambulant management by means of the V.A.C.(R)-therapy a meshgraft transplantation was performed (enlargement factor 1.5; layer thickness 0.3 mm). The V.A.C.(R)-device was applied again at a pressure of 150 mm Hg with a single dressing change after 5 days. At a follow-up of 31 months no further complications occurred. Discussion: The V.A.C.(R)-therapy seems to be a valuable tool in the treatment of wounds with a critical local vascularity. After successful wound preconditioning the healing process of skin grafts transplants can be also optimised by means of the V.A.C.(R)-device.
RP Kelm, J (通讯作者)，Univ Klinikum Saarlandes, Kirrbergerstr 1, D-66421 Homburg, Germany.
EM jk66421@hotmail.com
RI Anagnostakos, Konstantinos/MGC-8753-2025
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Dalton GP, 2001, CLIN ORTHOP RELAT R, P133
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Heugel JR, 2002, J BURN CARE REHABIL, V23, P167, DOI 10.1097/00004630-200205000-00005
   Kelm J, 2004, ZBL CHIR, V129, pS49, DOI 10.1055/s-2004-822611
   Morykwas MJ, 1999, J BURN CARE REHABIL, V20, P15, DOI 10.1097/00004630-199901001-00003
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   SCHUMPELICK V, 1997, OPERATIONSATLAS CHIR, P655
   Webb LX, 2001, UNFALLCHIRURG, V104, P918, DOI 10.1007/PL00002776
NR 9
TC 3
Z9 3
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S96
EP S99
DI 10.1055/s-2006-921509
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100022
PM 16575655
DA 2026-07-24
ER
PT J
AU Bourrée, M
   Kozianka, J
AF Bourrée, M
   Kozianka, J
TI 6 years V-AC® in general surgery - Clinical data from 128 patients
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE VAC (R) in general surgery; Fournier's gangrene; treatment of infection
AB Since the introduction of vacuum assisted closure therapy (V.A.C.(R)) at the Department of Surgery/St. Anna-Hospital Herne has taken place in 2000 there was a rapid increase of indications to use this therapy. We present data from 128 patients who were treated with this method from 2000-2005 for different kinds of diseases. We report the management of a 78-year-old male patient who developed a Fournier's gangrene after an acute appendicitis with retroperitoneal perforation and an enterocutaneus fistula of the cecum. Using V.A.C.(R) in surgery, a quick and safe treatment of infection and healing could be achieved.
C1 Privaten Univ Witten Herdecke, St Anna Hosp, Chirurg Klin, Ausbildungsklin, D-44649 Herne, Germany.
C3 Saint Anna Hospital
RP Bourrée, M (通讯作者)，Privaten Univ Witten Herdecke, St Anna Hosp, Chirurg Klin, Ausbildungsklin, Hosp Str 19, D-44649 Herne, Germany.
EM bourree@annahospital.de
CR AGENTA LC, 1997, ANN PLAST SURG, V38, P563
   BOURREE M, 2003, 35191 ACA, P35
   Fleischmann W, 1998, CHIRURG, V69, P222, DOI 10.1007/s001040050402
   Walgenbach KJ, 2000, Z FLUGWISS WELTRAUM, V13, P9
   Wild T, 2004, ZBL CHIR, V129, pS20, DOI 10.1055/s-2004-822651
NR 5
TC 3
Z9 3
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S100
EP S104
DI 10.1055/s-2006-921457
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100023
PM 16575656
DA 2026-07-24
ER
PT J
AU Fritze, F
   Hollerbuhl, H
   Gellert, K
AF Fritze, F
   Hollerbuhl, H
   Gellert, K
TI Vacuum assisted closure system in treatment of small bowel fistula
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
C1 Oskar Ziethen Krankenhaus, Sana Klinikum Lichtenberg, Klin Allgemein & Viszeralchirurg, D-10365 Berlin, Germany.
RP Fritze, F (通讯作者)，Oskar Ziethen Krankenhaus, Sana Klinikum Lichtenberg, Klin Allgemein & Viszeralchirurg, Fanningerstr 32, D-10365 Berlin, Germany.
EM Fraukefritze@aol.com
NR 0
TC 1
Z9 1
U1 0
U2 0
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S105
EP S107
DI 10.1055/s-2006-921494
PG 3
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100024
PM 16575657
DA 2026-07-24
ER
PT J
AU Hinck, D
   Struve, R
   Gatzka, F
   Schürmann, G
AF Hinck, D
   Struve, R
   Gatzka, F
   Schürmann, G
TI Vacuum-assisted fascial closure in the management of diffuse peritonitis
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE peritonitis; vacuum-assisted closure; laparostomy; abdominal compartment
   syndrome
ID LAVAGE
AB The surgical treatment of patients suffering from peritonitis with an open abdomen is commonplace. However scheduled as well as required dressing changes and peritoneal lavages mean a time- and costs-intensive challenge for the nursing and medical personnel. Since the introduction of the abdominal dressing-kit (KCI(R), Walluf, Germany) in the management of diffuse peritonitis one expects to influence the patients' recovery in a positive way due to the continuous evacuation of intraabdominal infectious fluids, augmentation of tissue's granulation, prevention of fascial retraction and prevention of an abdominal compartment syndrome. First on trial we established 2004 in our surgical department the use of the abdominal dressing-kit as a routine procedure in the management of diffuse peritonitis.
C1 Bundeswehrkrankenhaus Hamburg, Abt Allgemein Thorax & Viszeralchirurg, D-22049 Hamburg, Germany.
   Klinikum Itzehoe, Klin Allgemein Gefass & Viszeralchirurg, Itzehoe, Germany.
RP Hinck, D (通讯作者)，Bundeswehrkrankenhaus Hamburg, Abt Allgemein Thorax & Viszeralchirurg, Lesserstr 180, D-22049 Hamburg, Germany.
EM d.hinck@t-online.de
OI Hinck, Daniel/0000-0002-1226-4244
CR Kirschner M, 1926, ARCH KLIN CHIR, V142, P253
   MCKENNA JP, 1970, SURG GYNECOL OBSTETR, V130, P254
   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
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   PICHLMAYR R, 1983, CHIRURG, V54, P299
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NR 10
TC 6
Z9 6
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S108
EP S110
DI 10.1055/s-2006-921447
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100025
PM 16575658
DA 2026-07-24
ER
PT J
AU Weidenhagen, R
   Grützner, KU
   Kopp, R
   Spelsberg, FW
   Jauch, KW
AF Weidenhagen, R
   Grützner, KU
   Kopp, R
   Spelsberg, FW
   Jauch, KW
TI Role of vacuum therapy in the management of the septic abdomen
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE peritonitis; vacuum therapy; open abdomen; vacuum assisted closure;
   anastomotic leakage
ID TEMPORARY ABDOMINAL CLOSURE; ASSISTED CLOSURE; ENTEROCUTANEOUS FISTULA;
   FASCIAL CLOSURE; VENTRAL HERNIA; PACK TECHNIQUE; SURGERY; EXPERIENCES;
   PERITONITIS; SEPSIS
AB Progress in intensive care medicine contributed substantially in lowering the mortality rate of patients suffering from diffuse secondary peritonitis. In the medical care of patients presenting a septic abdomen the persisting septic focus is one of the greatest problems. This is associated with other problems like temporary closure of the abdomen, complications due to re-laparotomies, healing of the abdominal wall after soft tissue infection, loss of abdominal wall musculature, or persisting enteral fistulas. The vacuum therapy is used with increasing frequency for the treatment of septic complications in different areas of the body. The excellent drainage characteristics of the vacuum therapy appear to be a therapeutic option for the control of surgically untreatable septic processes in the abdominal cavity. More and more experience is gathered with the successful treatment of enterocutaneous fistulas, small intestine and pancreatic fistulas as well as anastomotic leakage after rectal surgery. There exist hardly any evidence-based recommendations for the application of vacuum therapy for treatment of the septic abdomen. But the good results of temporary closure of open abdomen of trauma patients by the vacuum therapy arises hope that the results can be transferred to the treatment modalities of persisting peritonitis. Additionally, these patients could profit from the drainage characteristics of the vacuum therapy.
C1 Univ Munich, Klinikum Grosshadern, Chirurg Klin & Poliklin, D-81377 Munich, Germany.
C3 University of Munich
RP Weidenhagen, R (通讯作者)，Univ Munich, Klinikum Grosshadern, Chirurg Klin & Poliklin, Marchioninistr 15, D-81377 Munich, Germany.
EM rolf.weidenhagen@med.uni-muenchen.de
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   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   BROCK WB, 1995, AM SURGEON, V61, P30
   Buchler MW, 1997, CHIRURG, V68, P811, DOI 10.1007/s001040050276
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   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
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   Garner GB, 2001, AM J SURG, V182, P630, DOI 10.1016/S0002-9610(01)00786-3
   Gonzalez-Avila Gabriel, 2005, Rev Gastroenterol Mex, V70, P158
   Hyon SH, 2000, ASAIO J, V46, P511, DOI 10.1097/00002480-200007000-00028
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   Labler L, 2004, ZBL CHIR, V129, pS14, DOI 10.1055/s-2004.822668
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   Wild T, 2004, ZBL CHIR, V129, pS20, DOI 10.1055/s-2004-822651
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NR 43
TC 16
Z9 17
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S115
EP S119
DI 10.1055/s-2006-921512
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100027
PM 16575660
DA 2026-07-24
ER
PT J
AU Frerichs, O
   Brüner, S
   Fansa, H
AF Frerichs, O
   Brüner, S
   Fansa, H
TI Value of VAC®-therapy in the treatment of sternal infections
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE sternal infection; VAC (R)-therapy; flap surgery
ID CHEST-WALL; FLAP; DEFECTS; REPAIR
AB Osteomyelitis of the sternum is a dreaded complication after sternotomy and is related to high mortality. Control of infection by radical debridement is the key to successful treatment. Instability of the thoracic cage can lead to a high complication rate. 16 Patients with an infected and unstable sternum underwent radical debridement with resection of the sternum and adjacent ribs. 6 Patients (group A) received an immediate defect coverage with a pedicled muscle flap. 10 Patients (group 13) were treated with a vacuum-assisted closure (V.A.C.(R))-therapy until stabilization of their general condition and underwent defect coverage in a second operation. Healing of the flaps was uneventful in all cases despite minor problems. 5 patients of group A had severe complications with pulmonal or cardiac failure and thoracic instability which lead to prolonged periods of mechanical ventilation. 2 patients of this group died due to multi organ failure. All patients of group B survived and there were no major complications. All of the patients were free of recurrence from their osteomyelitis during follow-up. V.A.C.(R)-therapy after radical resection of sternum osteomyelitis proved to be an effective measure to bridge time while optimizing the status of the patient and it's wound. With this approach we believe to have lowered the rate of major complications in this multimorbid patient group by reducing the burden of one large operation and by improving thoracic stability.
C1 Klinikum Bielefeld, Klin Plast Wiederherstellungs & Asthet Chirurg, D-33604 Bielefeld, Germany.
RP Frerichs, O (通讯作者)，Klinikum Bielefeld, Klin Plast Wiederherstellungs & Asthet Chirurg, Teutoburger Str 50, D-33604 Bielefeld, Germany.
EM onno.frerichs@sk-bielefeld.de
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
   ARNOLD PG, 1979, PLAST RECONSTR SURG, V63, P205, DOI 10.1097/00006534-197902000-00008
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   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   LIDSEY JT, 2002, PLAST RECONSTR SURG, V109, P1882
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NR 9
TC 1
Z9 3
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S120
EP S123
DI 10.1055/s-2006-921459
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100028
PM 16575661
DA 2026-07-24
ER
PT J
AU Loos, B
   Kopp, J
   Kneser, U
   Weyand, M
   Horch, RE
AF Loos, B
   Kopp, J
   Kneser, U
   Weyand, M
   Horch, RE
TI The importance of vacuum therapy in the treatment of sternal
   osteomyelitis from the plastic surgeons point of view
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE sternal osteomyelitis; plastic reconstruction; wound conditioning;
   vacuum therapy; tissue transfer
ID MUSCLE FLAPS; ASSISTED CLOSURE; WOUND CONTROL; FOUNDATION; EXPERIENCE
AB Background: Since its introduction in 1997 the vacuum assisted closure therapy has gained widespread and is for its indications international accepted. It is also well established in the treatment of sternal infections a dreaded complication after median sternotomy in cardiac surgery. The well known positive effects of the vacuum therapy act as a dignified cleaning procedure between debridement and plastic coverage or as a temporarily closure method if the first debridement was properbly not sufficient. Method and patients: Between January 2003 and December 2005 twenty-eight patients with advanced sternal infection after median sternotomy were treated by radical debridement, vacuum assisted closure therapy and definitive plastic coverage by muscle flaps. In this article three patients are exemplarily introduced. Results: In all patients a sufficient plastic coverage was achieved after radical debridement an vacuum assisted closure therapy. The patients received a pedicaled muscle flap. Stable wound condition with no signs of a recurrend sternal infection were observed in all patients. Discussion: Vacuum assisted closure therapy acts as a link between radical Debridement and definitive plastic coverage in prolonged sternal infection after median sternotomy. Before the invention of V.A.C.(R) dressing changes were obliged every day in patients with deep sternal infection. The V.A.C.(R) therapy reduces the frequency of this painful dressing changes significantly and on this behalf makes life more comfortable for this mostly multimorbide patients.
C1 Univ Erlangen Nurnberg, Chirurg Klin, Abt Plast & Handchirurg, D-91054 Erlangen, Germany.
   Univ Erlangen Nurnberg, Klin Herzchirurg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Loos, B (通讯作者)，Univ Erlangen Nurnberg, Chirurg Klin, Abt Plast & Handchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM Bernd.Loos@chir.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
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NR 15
TC 7
Z9 8
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S124
EP S128
DI 10.1055/s-2006-921425
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100029
PM 16575662
DA 2026-07-24
ER
PT J
AU Kutschka, I
   Dziadzka, S
   El Essawi, A
   Flory, PJ
   Harringer, W
AF Kutschka, I
   Dziadzka, S
   El Essawi, A
   Flory, PJ
   Harringer, W
TI Vacuum assisted closure for the treatment of sternal wound infections -
   Rapid infection control and bridging to reconstructive surgery
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
ID CARDIAC-SURGERY; MEDIASTINITIS; THERAPY
AB Vacuum Assisted Closure (V.A.C.(R)) is a sound strategy to control severe poststernotomy infection. Secondary re-wiring of the sternal bone or reconstructive surgery may be required later to achieve complete wound closure. Ten patients with severe sternal bone infection underwent initial V.A.C.(R) therapy and delayed surgery for wound closure. Complete wound healing was achieved in all cases. As a case report we describe a patient with right-sided mastectomy and irradiation for breast cancer, who developed severe poststernotomy infection and sternal bone necrosis following CABG. A combination of V.A.C.(R) therapy and surgical reconstruction using a pedicled latissimus dorsi musculocutaneous flap led to complete wound closure.
C1 Klinikum Braunschweig, Abt Herz Thorax & Gefasschirurg, D-38126 Braunschweig, Germany.
   Unfallchirurg Klinikum Braunschweig, Abt Plast Chirurg & Handchirurg, D-38126 Braunschweig, Germany.
RP Kutschka, I (通讯作者)，Klinikum Braunschweig, Abt Herz Thorax & Gefasschirurg, Salzdahlumerstr 90, D-38126 Braunschweig, Germany.
EM ingo.kutschka@t-online.de
RI El-Essawi, Aschraf/AFM-0248-2022
OI Harringer, Wolfgang/0000-0001-8899-4828; Kutschka,
   Ingo/0000-0002-7358-3513
CR Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Kutschka I, 2004, ZBL CHIR, V129, pS33, DOI 10.1055/s-2004-822607
   LOOP FD, 1990, ANN THORAC SURG, V49, P179, DOI 10.1016/0003-4975(90)90136-T
   MILANO CA, 1995, CIRCULATION, V92, P2245, DOI 10.1161/01.CIR.92.8.2245
   Rand RP, 1998, ANN THORAC SURG, V65, P1046, DOI 10.1016/S0003-4975(98)00087-3
NR 8
TC 3
Z9 6
U1 0
U2 4
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S129
EP S132
DI 10.1055/s-2006-921427
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100030
PM 16575663
DA 2026-07-24
ER
PT J
AU Ditterich, D
   Rexer, M
   Rupprecht, H
AF Ditterich, D
   Rexer, M
   Rupprecht, H
TI Vacuum assisted closure in the treatment of pleural empyema first
   experiences with intrathoracal application
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
DE vacuum-assisted closure; thoracic surgery; pleural empyema
ID STERNAL WOUND INFECTIONS; DEFINITIVE CLOSURE; THERAPY; SURGERY
AB Meanwhile vacuum-assisted closure (V.A.C.(R)) therapy belongs to the standard procedures in cardiovascular surgery. Its intrathoracal application is mentioned in one unique case-report in literature. We like to show our first experiences with this technique demonstrating three cases with pleural infection. One patient with bronchial stump insufficiency, one with pleural empyema and one with penetrating abscess of the chest was treated with V.A.C.(R)-therapy. We applied a combination of microporous silicon fleece and polyurethan foam in direct neighbourhood to ventilated lung areas inside the thoracic cavity. One patient died of metastasis of his cancer disease, while wound situation and bronchial stump insufficiency could be treated well. Two patients could be treated successfully and be discharged out of the hospital. No complications due to V.A.C.(R)-therapy could be seen, such as fistulas of the lung or bleeding of the mediastinal organs. Intrathoracal VA-C.(R)-therapy can be performed as a good therapeutic option in the treatment of septic diseases inside the chest.
C1 Chirurg Klin 1, D-90766 Furth, Germany.
RP Ditterich, D (通讯作者)，Chirurg Klin 1, Jakob Henle Str 1, D-90766 Furth, Germany.
EM dditterich@aol.com
CR Clubley Lisa, 2005, Nurs Times, V101, P44
   Ditterich D, 2004, ZBL CHIR, V129, pS137
   Fleck T, 2004, ZBL CHIR, V129, pS35, DOI 10.1055/s-2004-822615
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Kutschka I, 2004, ZBL CHIR, V129, pS33, DOI 10.1055/s-2004-822607
   O'Connor J, 2005, ANN THORAC SURG, V79, P1196, DOI 10.1016/j.athoracsur.2004.09.041
   Ramnarine IR, 2002, EUR J CARDIO-THORAC, V22, P1029, DOI 10.1016/S1010-7940(02)00562-6
   Scholl L, 2004, J CARDIAC SURG, V19, P453, DOI 10.1111/j.0886-0440.2004.05002.x
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Tang A T, 2000, J Wound Care, V9, P229
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
NR 12
TC 14
Z9 16
U1 0
U2 1
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S133
EP S138
DI 10.1055/s-2006-921499
PG 6
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100031
PM 16575664
DA 2026-07-24
ER
PT J
AU Rau, O
   Reiher, F
   Tautenhahn, J
   Allhoff, EP
AF Rau, O
   Reiher, F
   Tautenhahn, J
   Allhoff, EP
TI VAC® (Vacuum Assisted Closure™) therapy as a treatment option in
   complications following lymphadenectomy in patients with penile cancer
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE penile cancer; lymphadenectomy; secondary wound healing; VAC (R) therapy
ID SQUAMOUS-CELL-CARCINOMA; HUMAN-PAPILLOMAVIRUS; GROIN DISSECTION;
   MANAGEMENT
AB Introduction: Penile cancer is a rare tumor entity. Primary therapy consists of tumor excision (laser therapy, circumcision, partial or complete penectomy). Therapy of advanced or metastasized penile cancer is still challenging due to high morbidity with postoperative lymph edema, fistula, wound infection and resulting secondary wound healing. Methods: In this series we retrospectively investigated clinical and diagnostic data from 28 patients (1995-2005) with penile cancer regarding their follow-up, especially in respect to morbidity after lymphadenectomy and the resulting therapy. We evaluated the efficacy of V.A.C.(R) therapy as an alternative in this setting regarding costs and duration of hospital stay. Results: 11/28 pats. underwent lymphadenectomy(LA) because of tumor stage or suspicious lymph node status. Eight of those pats. developed complications, as there were: lymph edema, and/or secondary wound healing with fistula. 4/8 pats. were treated with V.A.C.(R) therapy. In this group a significant advantage regarding cost and time of hospitalization was observed. Discussion: Despite higher primary introduction costs an early V.A.C.(R) therapy in patients with secondary wound healing and lymph obstruction is advisable and resulted in a shortened hospitalization and reduced overall costs per patient.
C1 Univ Klinikum Magdeburg AoR, Urol Univ Klin, D-39120 Magdeburg, Germany.
   Univ Klinikum Magdeburg AoR, Zentrum Chirurg, D-39120 Magdeburg, Germany.
C3 University Hospital Magdeburg; University Hospital Magdeburg
RP Rau, O (通讯作者)，Univ Klinikum Magdeburg AoR, Urol Univ Klin, Leipziger Str 44, D-39120 Magdeburg, Germany.
EM olrik.rau@medizin.uni-magdeburg.de
CR Bezerra ALR, 2001, CANCER, V91, P2315, DOI 10.1002/1097-0142(20010615)91:12<2315::AID-CNCR1263>3.0.CO;2-C
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NR 20
TC 4
Z9 4
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S153
EP S156
DI 10.1055/s-2006-921486
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100036
PM 16575669
DA 2026-07-24
ER
PT J
AU Lehner, B
   Bernd, L
AF Lehner, B
   Bernd, L
TI VAC®-Instill therapy in periprodthetic infection of hip and knee
   arthroplasty
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE periprosthetic infection; early infection; retention of prosthesis;
   vacuum therapy; instillation therapy
ID PROSTHETIC JOINT INFECTION; DEBRIDEMENT; RETENTION; MANAGEMENT
AB Periprosthetic infection represents a main complication of arthroplasty. In case of an early infection the implant often can be left in place. Whether instillation of antiseptic solution using a reticulated sponge in combination with negative pressure wound therapy (V.A.C.(R)-instill) can be useful was the aim of our investigation. Up to now the instillation of Lavasept in combination with negative pressure wound therapy could be performed in three patients. In two cases an early infection of a hip prosthesis and one infected knee implant had to be treated. Following surgical debridement V.A.C.(R)-instill therapy was performed for 4-7 days followed by closure of the wound or a repeated application. Lavasept was used for irrigation. In all three cases retention of the primary implant could be achieved. The follow up now is 8 to 22 weeks. No recurrence of the infection occurred. After salvage of the prosthesis the joint allowed full load bearing and painfree mobilisation. The V.A.C.(R)-instill system proved to be easy to use. With this system early periprosthetic infection with antiseptic irrigation in combination with negative pressure wound therapy decreasing the bacterial burden, salvage of prosthesis seems to be possible. The therapy is applicable in hip and knee prosthesis. Final conclusions about this therapy however can be done only after a larger series of patients.
C1 Stiftung Orthopad Univ Klin, D-69118 Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg
RP Lehner, B (通讯作者)，Stiftung Orthopad Univ Klin, Schlierbacher Landstr 200 A, D-69118 Heidelberg, Germany.
EM burkhard.lehner@ok.uni-heidelberg.de
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   Kalteis T, 2003, Z ORTHOP GRENZGEB, V141, P233, DOI 10.1055/s-2003-38654
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   MELLASCHMIDT C, 1989, CHIRURG, V60, P791
   Ruchholtz S, 2004, UNFALLCHIRURG, V107, P307, DOI 10.1007/s00113-004-0751-9
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   Sofer D, 2005, ORTHOPADE, V34, P590, DOI 10.1007/s00132-005-0780-2
   Tattevin P, 1999, CLIN INFECT DIS, V29, P292, DOI 10.1086/520202
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   Wolvos Tom, 2004, Ostomy Wound Manage, V50, P56
   Zimmerli W, 2003, INFECTION, V31, P99, DOI 10.1007/s15010-002-3079-9
NR 19
TC 26
Z9 27
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S160
EP S164
DI 10.1055/s-2006-921513
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100038
PM 16575671
DA 2026-07-24
ER
PT J
AU Dissemond, J
   Körber, A
   Grabbe, S
AF Dissemond, J
   Körber, A
   Grabbe, S
TI Take of mesh grafts in chronic leg ulcer patients improves by
   vacuum-assisted closure device
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE vacuum-assisted closure; leg ulcer; chronic wound; mesh graft;
   skin-graft
AB Vacuum-assisted closure (V.A.C.(R)) is an established therapeutic option in the management of acute and chronic granulating wounds. In recent years, little data has been published concerning skin graft transplantation and postoperative V.A.C.(R) therapy. We report a consecutive case series of 54 patients with chronic leg ulcer who received a total of 74 mesh grafts. A postoperative V.A.C.(R) therapy was performed in 28 mesh grafts, and 46 mesh grafts were treated with standard gauze therapy. In the V.A.C.(R) group, 92.9% grafts showed complete healing. In the treatment group without postoperative V.A.C.(R) therapy, 67.4% of the mesh grafts had taken. Differential analysis revealed a correlation in patients over 70 years of age or in patients suffering from diabetes mellitus or dermatoliposclerosis. Particularly patients with diabetes mellitus and of greater age exhibited improved take rates in the V.A.C.(R) group. The results of our study demonstrate for the first time the significant benefit of V.A.C.(R) therapy after mesh-graft-transplantation in chronic leg ulcer patients as evaluated in a clinical trial with a control group.
C1 Univ Klinikum Essen, Dermatol Klin & Poliklin, D-45122 Essen, Germany.
C3 University of Duisburg Essen
RP Dissemond, J (通讯作者)，Univ Klinikum Essen, Dermatol Klin & Poliklin, Hufelandstr 55, D-45122 Essen, Germany.
EM joachimdissemond@hotmail.com
RI Grabe, Stephan/AAJ-4578-2021; Dissemond, Joachim/AFG-0691-2022
CR Carson Stanley N, 2004, Ostomy Wound Manage, V50, P52
   FLEISCHMANN W, 1996, UNFALLCHIRURG, V9, P488
   KARL T, 2005, VASOMED, V5, P172
   KIRSNER RS, 1995, DERMATOL SURG, V21, P701, DOI 10.1111/j.1524-4725.1995.tb00273.x
   Korber A, 2005, WUNDFORUM, V3, P8
   PFAU M, 2001, AKTUEL TRAUMATOL, V31, P232
   SCHERER LA, 2002, ARCH SURG-CHICAGO, V8, P930
   Sposato G, 2001, BRIT J PLAST SURG, V54, P235, DOI 10.1054/bjps.2000.3537
   Turczynski R, 1999, SCAND J PLAST RECONS, V33, P301
   WOOD MK, 1995, ANN ROY COLL SURG, V77, P222
NR 10
TC 2
Z9 2
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S165
EP S167
DI 10.1055/s-2006-921449
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100039
PM 16575672
DA 2026-07-24
ER
PT J
AU Fiebiger, M
   Innertsberger, W
   Molcan, J
AF Fiebiger, M
   Innertsberger, W
   Molcan, J
TI Multi therapy of large chronic leg ulcera: A combination of necrectomy,
   vacuum assisted closure and mesh graft
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
C1 EMCO Privatklin, A-5020 Salzburg, Austria.
RP Fiebiger, M (通讯作者)，EMCO Privatklin, Irma Troll Str 6, A-5020 Salzburg, Austria.
EM office@fiebiger.at
CR TRAUTVETTER T, 2004, ZENTRALBL CHIR S1, V129, pS38
NR 1
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S168
EP S169
DI 10.1055/s-2006-921458
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100040
PM 16575673
DA 2026-07-24
ER
PT J
AU Gesslein, M
   Horch, RE
AF Gesslein, M
   Horch, RE
TI Interdisciplinary management of complex chronic ulcers using vacuum
   assisted closure therapy and "buried chip skin grafts"
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
DE VAC (R)-therapy; diabetic foot syndrome; buried chip skin grafts
AB History and admission findings: We report the case of a 68-year-old female patient who was admitted to the hospital with deranged blood sugar levels in a septic condition. Due to complex chronic ulcerations of both feet she was intended for major amputation of both limbs. Clinical findings on admission were a diabetic foot syndrome with stage DIV ulcerations according to the Wagner and Armstrong classification, partially visible tendons and phlegmon of the lower leg. Investigations and clinical course: Vascular diagnostic revealed arterial occlusive disease in the lower legs without chance of reconstruction. Enterococcus faecalis and Staphylococcus aureus were extracted in swabs from ulcers. After correction of metabolic status and antibiotic treatment radical debridement of all ulcers was carried out and vacuum assisted closure therapy (V.A.C.(R)) was initiated. All wounds showed good granulation tissue after four cycles of V.A.C.(R)-therapy. Interdisciplinary treatment with a plastic surgeon was initiated to accelerate epithelial closure. Using the "Buried Skin Chip" technique in combination with V.A.C.(R)-therapy epithelialisation was completed within four weeks. The patient recovered well and was fully independent on discharge. Discussion and Conclusion: A goal-oriented interdisciplinary setting can achieve preservation of extremities even in septic patients. The combination of buried skin chip grafts and V.A.C.(R)-therapy may be a feasible and promising procedure to achieve accelerated wound closure in those patients.
C1 Klinikum Nurnberg Sud, Klin Unfall & Orthopad Chirurg, D-90471 Nurnberg, Germany.
   Univ Erlangen Nurnberg, Chirurg Klin & Poliklin, Abt Plast & Handchirurg, D-8520 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Gesslein, M (通讯作者)，Klinikum Nurnberg Sud, Klin Unfall & Orthopad Chirurg, Breslauer Str 201, D-90471 Nurnberg, Germany.
EM mgesslein@aol.com
RI Horch, Raymund E/H-8128-2019; Gesslein, Markus/O-4858-2019
OI Horch, Raymund E/0000-0002-6561-2353; Gesslein,
   Markus/0000-0003-3863-1580
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   GOLDBERG JA, 1991, CLIN PLAST SURG, V18, P459
   Kopp J, 2004, ZBL CHIR, V129, pS129, DOI 10.1055/s-2004-822649
   Kopp Jurgen, 2004, Int J Low Extrem Wounds, V3, P168, DOI 10.1177/1534734604268092
   Sawada Y, 1998, Acta Chir Plast, V40, P68
   SAWADA Y, 1989, BURNS, V15, P36, DOI 10.1016/0305-4179(89)90067-3
NR 6
TC 12
Z9 13
U1 0
U2 2
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S170
EP S173
DI 10.1055/s-2006-921460
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100041
PM 16575674
DA 2026-07-24
ER
PT J
AU Wetzel-Roth, W
AF Wetzel-Roth, W
TI VAC®-Therapy as a hygienic procedure tool: Protection of the environment
   of wounds and patients with multiresistant bacteria in clinical and
   outpatient treatment
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
ID VACUUM-ASSISTED CLOSURE
C1 Buchloe Tagesklin, Belegarzt Stad Krankenhaus Schwabmunchen, D-86807 Buchloe, Germany.
RP Wetzel-Roth, W (通讯作者)，Facharzt Chirurg Thorax Kardiovaskularchirurg, Hindenburgstr 1, D-86807 Buchloe, Germany.
EM info@wetzel-roth.de
CR Horch R E, 2005, MMW Fortschr Med, V147 Suppl 1, P1
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   WILLY C, 2005, VAKUUMTHERAPIE
   2000, BGBL, V1, P1045
NR 5
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S180
EP S181
DI 10.1055/s-2006-921516
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100044
PM 16575677
DA 2026-07-24
ER
PT J
AU Nord, D
AF Nord, D
TI Cost-effectiveness in wound care
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
DE wound healing; vacuum assisted closure; effectiveness; efficiency;
   costs; savings
ID ULCER PREVALENCE; THERAPY
AB Introduction: In Germany, treatment costs for pressure ulcer, diabetic foot ulcer and ulcus cruris sum up to Euro 5 billion p. a. (cost of materials only). The question is to be answered how much money could be saved to sick funds, if the treatment is switched from traditional wound care, e.g. hydrocolloids to Vacuum Assisted Closure (V.A.C.(R)). Methods: Clinical studies are analysed with regard to complication rates and speed of wound healing V.A.C.(R) vs. traditional. Daily costs and the length of treatment are then correlated and compared. Results: V.A.C.(R) therapy significantly reduces the time for the wound closing process, hospital admissions and complication rates. Despite higher daily treatment costs (cost of material, only), the V.A.C.(R) therapy turns out to be the superior cost-effective method by far. Assumed V.A.C.(R) therapy substitutes other methods by 50%, sick funds could have saved Euro 0.7 billion p. a. Discussion: The V.A.C.(R) related saving potential is not available to sick funds because the approval process for home care use is still (Jan 2006) ongoing since 1999. The improvement of the relevant decision making process is strongly required to faster provide better care and savings at the same time.
C1 Univ Konstanz, D-69118 Heidelberg, Germany.
C3 University of Konstanz
RP Nord, D (通讯作者)，Univ Konstanz, Schweizertalstr 10, D-69118 Heidelberg, Germany.
EM dietrich.nord@drnord.com
CR ANDERSSON E, 1993, ACTA DERM-VENEREOL, V73, P57
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   NORD D, 2002, NIEDERGELASENE CHIRU, V6, P3
   Pelka R, 1997, Krankenpfl J, V35, P338
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Schwien T, 2005, OSTOMY WOUND MANAG, V51, P47
   WILLY C, 2003, ULM              NOV, P101
   WILLY C, 2003, VAKUUMVERSIEGELUNGST
   2006, VORSTANDSGEHALTER SO
   2000, BERUFSFACHVERBAND ME
NR 10
TC 15
Z9 17
U1 0
U2 5
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S185
EP S188
DI 10.1055/s-2006-921433
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100046
PM 16575679
DA 2026-07-24
ER
PT J
AU Reed, T
   Economon, D
   Wiersema-Bryant, L
AF Reed, T
   Economon, D
   Wiersema-Bryant, L
TI Colocutaneous fistula management in a dehisced wound: A case study
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE fistula; wound dehiscence; negative pressure wound therapy; drainage
ID ENTEROCUTANEOUS FISTULAS
AB A fistula is an abnormal opening between two or more organs or structures. Wound drainage containment is a key component of nonsurgical fistula management and may include pouches, skin barriers, transparent dressings, troughing procedures, saddle bagging, bridging, and condom and suction catheters used in combination with complex or routine pouching. Following extensive abdominal surgery, the wound of a 50-year-old woman dehisced and a colocutaneous fistula formed inside the wound. The wound containing the fistula, which was draining liquid stool, was too large for existing commercial pouching systems. When initial management efforts, including negative pressure wound therapy, failed to achieve containment goals, clinicians adapted the negative pressure wound therapy dressing to surround the fistula, which helped facilitate therapy while providing a platform for an ostomy appliance to contain the fistula drainage. The system was changed every 2 days until discharge. The wound and fistula management combination improved patient comfort and mobility, facilitated healing, and reduced patient dietary restrictions.
C1 Barnes Jewish Hosp, BJC Hlth Care, St Louis, MO 63110 USA.
C3 Barnes-Jewish Hospital; Washington University (WUSTL)
RP Reed, T (通讯作者)，Barnes Jewish Hosp, BJC Hlth Care, St Louis, MO 63110 USA.
EM txr9446@bjc.org
CR Berry SM, 1996, SURG CLIN N AM, V76, P1009, DOI 10.1016/S0039-6109(05)70495-3
   BRYANT RA, 2000, NURSING MANAGEMENT
   CLEVERLY J, MANAGEMENT FISTULA W
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   HAMPTON BG, 1992, NURSING MANAGEMENT
   *KCI MED, 2003, VAC THER CLIN GUID
   MCKEE M, MANAGEMENT COMPLEX O
NR 8
TC 8
Z9 8
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD APR
PY 2006
VL 52
IS 4
BP 60
EP +
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 036AY
UT WOS:000237044400012
PM 16636363
DA 2026-07-24
ER
PT J
AU DeFranzo, AJ
   Argenta, L
AF DeFranzo, AJ
   Argenta, L
TI Vacuum-assisted closure for the treatment of abdominal wounds
SO CLINICS IN PLASTIC SURGERY
LA English
DT Article
ID GROWTH-FACTOR; ELONGATION
AB Abdominal wall defects pose a significant surgical challenge. The defect may result from trauma, infections, previous major surgery or some combination of these etiologies. This article describes the Vacuum-Assisted Closure device (VAC, KCl, San Antonio, Texas) and how it can help in treating these defects.
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University
RP DeFranzo, AJ (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM adefranz@wfubmc.edu
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NR 39
TC 19
Z9 38
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0094-1298
EI 1558-0504
J9 CLIN PLAST SURG
JI Clin. Plast. Surg.
PD APR
PY 2006
VL 33
IS 2
BP 213
EP +
DI 10.1016/j.cps.2005.12.007
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 039AD
UT WOS:000237270500005
PM 16638464
DA 2026-07-24
ER
PT J
AU Kilpadi, D
   Bower, CE
   Reade, CC
   Robinson, PJ
   Sun, YS
   Zeri, R
   Nifong, LW
   Wooden, WA
AF Kilpadi, D
   Bower, CE
   Reade, CC
   Robinson, PJ
   Sun, YS
   Zeri, R
   Nifong, LW
   Wooden, WA
TI Effect of Vacuum Assisted Closure® Therapy on early systemic cytokine
   levels in a swine model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID PORCINE SKIN WOUNDS; GROWTH-FACTOR-BETA; GENE-EXPRESSION; TGF-BETA;
   INTERLEUKIN-6; IL-10; INFLAMMATION; ACTIVATION; PRESSURE; SURGERY
AB Vacuum Assisted Closure (R) (V.A.C.(R)) Therapy has previously been shown to facilitate healing of wounds. However, the physiological mechanism(s) of this treatment modality and its systemic effects require further investigations. The goal of this porcine study was to investigate the effect of V.A.C.(R) Therapy on the systemic distribution of the inflammatory cytokines interleukin (IL)-6, IL-8, IL-10, and transforming growth factor-beta 1. Twelve pigs were each given one full-thickness excisional wound. using electrocautery. Six of the pigs were treated with V.A.C.(R) Therapy and six with saline-moistened gauze. Serum samples were collected immediately after Wound creation, and hourly for 4 hours. Samples were analyzed using commercially available enzyme-linked immunosorbent assay kits. During the initial 4 hours of treatment, V.A.C.(R) Therapy resulted in earlier and greater peaking of IL-10 and maintenance of IL-6 levels compared with saline-moistened gauze controls, which showed decreased IL-6 values over the first hour (both at p < 0.05). No other treatment-based differences were detected.
C1 KCI, Global R&D, New Technol, San Antonio, TX 78249 USA.
   E Carolina Univ, Brody Sch Med, Dept Surg, Greenville, NC USA.
C3 University of North Carolina; East Carolina University
RP Kilpadi, D (通讯作者)，KCI, Global R&D, New Technol, 6203 Farinon, San Antonio, TX 78249 USA.
EM kilpadid@kci1.com
RI Robinson, Phil/HZH-9227-2023; Bower, Curtis/ABG-6186-2021
CR Akdis CA, 2001, IMMUNOLOGY, V103, P131, DOI 10.1046/j.1365-2567.2001.01235.x
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   Black C A, 1999, Dermatol Online J, V5, P7
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NR 42
TC 35
Z9 52
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2006
VL 14
IS 2
BP 210
EP 215
DI 10.1111/j.1743-6109.2006.00112.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 040CW
UT WOS:000237357600016
PM 16630111
DA 2026-07-24
ER
PT J
AU Plikaitis, CM
   Molnar, JA
AF Plikaitis, Christina M.
   Molnar, Joseph A.
TI Subatmospheric pressure wound therapy and the vacuum-assisted closure
   device: basic science and current clinical successes
SO EXPERT REVIEW OF MEDICAL DEVICES
LA English
DT Review
DE negative pressure wound therapy; subatmospheric pressure therapy;
   topical negative pressure; vacuum-assisted closure; wound instillation
   therapy; wounds
ID SECURING SKIN-GRAFTS; FASCIAL CLOSURE; OPEN ABDOMEN; DEFINITIVE CLOSURE;
   ABDOMINAL CLOSURE; ARTIFICIAL SKIN; TISSUE DEFECTS; VENTRAL HERNIA;
   MANAGEMENT; SYSTEM
AB This article reviews the development, current theories behind the mechanism of action and clinical use of subatmospheric pressure wound therapy with the vacuum-assisted closure device. An evolving list of indications for subatmospheric pressure therapy is discussed including its use in chronic wounds, traumatic wounds and orthopedic salvage, infected sternal wounds, management of the open abdomen, enterocutaneous fistulae, burn wounds, skin grafts and dermal substitutes, as well as systemic disease processes, such as myoglobinuria. The vacuum-assisted closure device Instill (R) system is also reviewed, in which subatmospheric pressure therapy has been combined with the instillation of therapeutic solutions for the treatment of difficult infected wounds.
C1 Wake Forest Univ, Baptist Med Ctr, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Molnar, JA (通讯作者)，Wake Forest Univ, Baptist Med Ctr, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
EM jmolnar@wfubmc.edu
RI Molnar, Joseph/AEK-5540-2022
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   2005, KCI              JAN
NR 52
TC 53
Z9 76
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1743-4440
EI 1745-2422
J9 EXPERT REV MED DEVIC
JI Expert Rev. Med. Devices
PD MAR
PY 2006
VL 3
IS 2
BP 175
EP 184
DI 10.1586/17434440.3.2.175
PG 10
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA 044PR
UT WOS:000237685200011
PM 16515384
DA 2026-07-24
ER
PT J
AU Parrett, BM
   Pomahac, B
   Demling, RH
   Orgill, DP
AF Parrett, Brian M.
   Pomahac, Bohdan
   Demling, Robert H.
   Orgill, Dennis P.
TI Fourth-degree burns to the lower extremity with exposed tendon and bone:
   A ten-year experience
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article; Proceedings Paper
CT 37th Annual Meeting of the American-Burn-Association
CY MAY 10-13, 2005
CL Chicago, IL
SP Amer Burn Assoc
ID VACUUM-ASSISTED CLOSURE; BELOW-KNEE; AMPUTATION LEVEL; FREE FLAPS;
   AMPUTEES; MANAGEMENT; WOUNDS; REHABILITATION; RECONSTRUCTION; EXCISION
AB Fourth-degree extremity burns involve muscle, tendon, and bone, often leading to amputation or significant functional impairment. We report our 10-year experience (1995-2004) at an urban burn center with fourth-degree burns to the lower extremity to characterize treatments and outcomes. Twenty-one patients (40 limbs), mean age of 45 years, were treated for fourth-degree lower-extremity burns with the average extremity burn size of 24% TBSA (range, 2-36%) and a mean fourth-degree burn size of 9% TBSA (range, 2-18%). A mean of eight operations were required for limb salvage. Six free-tissue transfers, 2 fillet flaps, 14 local flaps, and multiple skin grafts were performed. Five patients underwent tibial burring for granulation tissue stimulation, and the subatmospheric pressure device was used in eight patients. Seven limb amputations (18%) were required in four patients, and 76% of patients were ambulatory on follow-up. The mean hospital stay was 76 days with high rates of cellulitis, deep vein thrombosis, and bacteremia. Patients treated with flap closure had a significant decrease in the number of operations required for limb salvage. Fourth-degree lower-extremity burns require multistage reconstructive procedures using multiple levels of the reconstructive ladder but limb salvage is possible in a majority of cases.
C1 Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast & Reconstruct Surg, Boston, MA 02215 USA.
   Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Trauma Burns & Crit Care, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   Medical School
RP Orgill, DP (通讯作者)，Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast & Reconstruct Surg, 75 Francis St, Boston, MA 02215 USA.
RI Orgill, Dennis/H-7596-2019; Pomahac, Bohdan/AAH-1792-2019
OI Orgill, Dennis/0000-0002-8279-7310; Pomahac, Bohdan/0000-0003-3703-8240
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NR 36
TC 31
Z9 40
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2006
VL 27
IS 1
BP 34
EP 39
DI 10.1097/01.bcr.0000192265.20514.c5
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Dermatology; Surgery
GA 044UJ
UT WOS:000237697600006
PM 16566535
DA 2026-07-24
ER
PT J
AU Baradarian, S
   Stahovich, M
   Krause, S
   Adamson, R
   Dembitsky, W
AF Baradarian, Sam
   Stahovich, Marcia
   Krause, Susan
   Adamson, Robert
   Dembitsky, Walter
TI Case series: Clinical management of persistent mechanical assist device
   driveline drainage using vacuum-assisted closure therapy
SO ASAIO JOURNAL
LA English
DT Article
ID INFECTION
AB Percutaneous driveline lead and pocket sites are potential sources of drainage that can lead to infection. Some patients experience a slower closure of tissue growth into the driveline. The management of chronically open and or draining driveline wounds is a challenge. The KCl vacuum-assisted closure (VAC) device is a noninvasive negative-pressure therapy that promotes the healing of wounds not responding to conventional treatment. Vacuum-assisted closure therapy has proven safe, effective, and cost efficient by decreasing the number of dressing changes and length of stay. The left ventricular assist device (LVAD) team initiated VAC therapy in 3 patients. The tunneling method allowed the wound to heal from the inside out. The dressing was changed every 3 days, and the size and depth of the wound was monitored. Patients may be sent home using a portable VAC device until wound closure is obtained, which decreases the hospital length of stay. Our experience with three patients suggests the VAC device can be used for draining and tunneling LVAD driveline-site wounds and may prevent fistula formation. It is especially useful for patients with ascites that may be draining along the driveline tract. The sites showed increased granulation, decreased drainage, and a reduced bacterial burden after having the device in place.
C1 Sharp Mem Hosp & Rehabil Ctr, Mech Assist Device Dept, San Diego, CA 92123 USA.
   Sharp Mem Hosp & Rehabil Ctr, Wound Healing Dept, San Diego, CA 92123 USA.
C3 Sharp Memorial Hospital Rehabilitation & Physical Therapy; Sharp
   Memorial Hospital Rehabilitation & Physical Therapy
RP Stahovich, M (通讯作者)，Sharp Mem Hosp & Rehabil Ctr, Mech Assist Device Dept, 7901 Frost St, San Diego, CA 92123 USA.
CR Bentz Barbara, 2004, J Cardiovasc Manag, V15, P9
   Choi L, 1999, J HEART LUNG TRANSPL, V18, P1103, DOI 10.1016/S1053-2498(99)00076-5
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Hutchinson OZ, 2001, PLAST RECONSTR SURG, V107, P364, DOI 10.1097/00006534-200102000-00011
   Jarvik R, 1998, ANN THORAC SURG, V65, P470, DOI 10.1016/S0003-4975(97)01343-X
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   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 7
TC 32
Z9 33
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1058-2916
EI 1538-943X
J9 ASAIO J
JI Asaio J.
PD MAY-JUN
PY 2006
VL 52
IS 3
BP 354
EP 356
DI 10.1097/01.mat.0000204760.48157.cc
PG 3
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA 046UE
UT WOS:000237835800022
PM 16760728
DA 2026-07-24
ER
PT J
AU Kilpadi, DV
   Stechmiller, JK
   Childress, B
   Cowan, L
   Comerio, M
   Kieswetter, K
   Schultz, G
AF Kilpadi, Deepak V.
   Stechmiller, Joyce K.
   Childress, Beverly
   Cowan, Linda
   Comerio, Melissa
   Kieswetter, Kristine
   Schultz, Gregory
TI Composition of wound fluid from pressure ulcers treated with negative
   pressure wound therapy using VAC® therapy in home health or extended
   care patients:: A pilot study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MATRIX-METALLOPROTEINASE; TISSUE INHIBITORS;
   HUMAN SKIN; EXPRESSION; TIMP-1
AB The purpose of this pilot study was to characterize changes in concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, matrix metalloproteinase (MMP)-3, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1 in wound fluid collected from pressure ulcers in adults treated with negative pressure wound therapy (NPWT; V.A.C.(R) Therapy, KCl, Son Antonio, Tex). Wound fluids were collected from 8 patients with Stage III or IV pressure ulcers in home care and extended care settings. Concentrations of analytes were measured immediately prior to initiation of NPWT (Day 0) and at Days 1, 3, and 7 continuous NPWT. There were statistically significant (P < 0.05) decreases from baseline in the levels of MMP-3 (Day 0 > [Day 1 similar to Day 3 similar to Day 7]), MMP-9 (Day 0 > [Day 1 similar to Day 3]), and MMP-3:TIMP-1 ratios (Day 0 > [Day 1 similar to Day 3 similar to Day 7]). No other significant differences were detected. Previous studies have shown a consistent decrease in protease levels to have prognostic value for healing. Thus, the change in composition of fluids from pressure ulcers treated with NPWT may be beneficial to wound healing.
C1 Kinet Concepts Inc, Global R&D, San Antonio, TX 78249 USA.
   Univ Florida, Coll Nursing, Gainesville, FL 32611 USA.
   N Florida S Georgia Vet Hlth Syst, Rehabil Outcomes Res Ctr Excellence, Gainesville, FL USA.
   Univ Florida, Coll Med, Gainesville, FL USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Kilpadi, DV (通讯作者)，Kinet Concepts Inc, Global R&D, 6203 Farinon, San Antonio, TX 78249 USA.
EM kilpadid@kci1.com
RI Cowan, Linda/JLK-9224-2023
CR [Anonymous], AHCPR PUB
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NR 40
TC 13
Z9 14
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2006
VL 18
IS 5
BP 119
EP 128
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 047AX
UT WOS:000237853300004
DA 2026-07-24
ER
PT J
AU Stokes, TH
   Follmar, KE
   Silverstein, AD
   Weizer, AZ
   Donatucci, CF
   Anderson, EE
   Erdmann, D
AF Stokes, Tracey H.
   Follmar, Keith E.
   Silverstein, Ari D.
   Weizer, Alon Z.
   Donatucci, Craig F.
   Anderson, Everett E.
   Erdmann, Detlev
TI Use of negative-pressure dressings and split-thickness skin grafts
   following penile shaft reduction and reduction scrotoplasty in the
   management of penoscrotal elephantiasis
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE elephantiasis; penoscrotal lymphedema; penile reconstruction;
   split-thickness skin graft; vacuum-assisted closure dressing
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; LYMPHEDEMA; SCROTUM; BOLSTER
AB From 1988 to 2005, 8 men who presented with penoscrotal elephantiasis underwent penile shaft degloving and reduction scrotoplasty, followed by transplantation of a split-thickness skin graft (STSG) to the penile shaft. The etiology of elephantiasis in these patients included self-injection of viscous fluid and postsurgical obstructive lymphedema. In the 6 most recent cases, negative-pressure dressings were applied over the STSG to promote graft take, and STSG take rate was 100%. The results of our series corroborate those of a previous report, which showed circumferential negative-pressure dressings to be safe and efficacious in bolstering STSGs to the penile shaft. Furthermore, these results suggest that the use of negative-pressure dressings may improve graft take in this patient population.
C1 Duke Univ, Med Ctr, Div Plast Reconstruct Maxillofacial & Oral Surg, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Div Urol, Durham, NC 27710 USA.
   Duke Univ, Sch Med, Durham, NC 27710 USA.
C3 Duke University; Duke University; Duke University
RP Erdmann, D (通讯作者)，Duke Univ, Med Ctr, Div Plast Reconstruct Maxillofacial & Oral Surg, Box 3181, Durham, NC 27710 USA.
EM Detlev.Erdmann@duke.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BEHAR TA, 1993, PLAST RECONSTR SURG, V91, P352, DOI 10.1097/00006534-199302000-00024
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   DANDAPAT MC, 1985, AM J SURG, V149, P686
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   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Ndoye A, 1999, BJU INT, V84, P362
   O'Rourke M G, 1967, Br J Urol, V39, P426, DOI 10.1111/j.1464-410X.1967.tb09824.x
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NR 13
TC 34
Z9 36
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2006
VL 56
IS 6
BP 649
EP 653
DI 10.1097/01.sap.0000202826.61782.c9
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 047CN
UT WOS:000237857500013
PM 16721079
DA 2026-07-24
ER
PT J
AU Dickie, SR
   Dorafshar, AH
   Song, DH
AF Dickie, Sara R.
   Dorafshar, Amir H.
   Song, David H.
TI Definitive closure of the infected median sternotomy wound - A treatment
   algorithm utilizing vacuum-assisted closure followed by rigid plate
   fixation
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE mediastinitis; sternal wound dehiscence; sternal wound reconstruction;
   sternal plate; VAC; rigid sternal fixation
ID FLAP RECONSTRUCTION; MEDIASTINAL INFECTION; INTERNAL-FIXATION; STERNAL
   NONUNION; HEART SURGERY; MUSCLE FLAPS; COMPLICATIONS; MANAGEMENT;
   DEVICE; BRIDGE
AB Mediastinitis and sternal wound dehiscence are devastating and life-threatening complications of median stemotomy incision. Ten consecutive patients between July 2001 and May 2005 were diagnosed with sternal wound infection and dehiscence following median sternotomy. Patients were managed by precise debridement and wound excision in the operating room and then dressed with vacuum-assisted closure device. Intravenous antibiotics were prescribed for wound and blood culture microbiological sensitivity, When wounds were bacteriologically controlled, patients returned to the operating room for definitive closure using rigid sternal plating. All patients were extubated postoperatively. No patients died. Average total hospital stay was 21 days. The pectoralis advancement flap was exclusively used for soft tissue reconstruction in 7 patients. There were 2 cases of chronic superficial sternal infection requiring plate removal; however, bony union of the sternum was achieved in all patients. This treatment algorithm provides a useful management strategy for patients with complicated median stemotomy.
C1 Univ Chicago Hosp, Plast & Reconstruct Surg Sect, Chicago, IL 60637 USA.
C3 University of Illinois System; University of Chicago; University of
   Chicago Medical Center
RP Song, DH (通讯作者)，Univ Chicago Hosp, Plast & Reconstruct Surg Sect, 5841 S Maryland Ave,MC 6035, Chicago, IL 60637 USA.
EM dsong@surgery.bsd.uchicago.edu
RI Dorafshar, Amir/AAP-2657-2021
OI Dorafshar, Amir/0000-0001-7045-3601
CR Argenta L, 1993, JOINT M WOUND HEAL S
   BRYANT LR, 1969, ANN SURG, V169, P914, DOI 10.1097/00000658-196906000-00011
   Chase CW, 1999, PLAST RECONSTR SURG, V103, P1667, DOI 10.1097/00006534-199905060-00014
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   Cohen M, 1997, ANN PLAS SURG, V39, P36, DOI 10.1097/00000637-199707000-00006
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NR 26
TC 13
Z9 14
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2006
VL 56
IS 6
BP 680
EP 685
DI 10.1097/01.sap.0000202825.41069.c3
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 047CN
UT WOS:000237857500019
PM 16721085
DA 2026-07-24
ER
PT J
AU Ozer, K
   Smith, W
AF Ozer, Kagan
   Smith, Wade
TI A simple technique for applying vacuum-assisted closure therapy over the
   circular type external fixation device
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE circular external fixator; vacuum-assisted wound closure; skin grafting
ID WOUND CONTROL
AB Vacuum-assisted closure (VAC) therapy is a widely used method to promote granulation tissue in lower-extremity wounds. However, maintenance of a tight seal over irregular surfaces is difficult, especially around ring fixators. The presented technique in this article offers a time-saving and safe method to achieve an airtight seal around circular fixator in VAC therapy.
C1 Univ Colorado, Hlth Sci Ctr, Denver Hlth Med Ctr, Dept Orthoped, Denver, CO 80204 USA.
C3 University of Colorado System; University of Colorado Anschutz; Denver
   Health Medical Center; University of Colorado Denver
RP Ozer, K (通讯作者)，Univ Colorado, Hlth Sci Ctr, Denver Hlth Med Ctr, Dept Orthoped, MC0188,777 Bannock St, Denver, CO 80204 USA.
EM kagan.ozer@dhha.org
OI Ozer, Kagan/0000-0001-7397-3696
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
NR 3
TC 9
Z9 9
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2006
VL 56
IS 6
BP 693
EP 694
DI 10.1097/01.sap.0000203997.70550.f8
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 047CN
UT WOS:000237857500022
PM 16721088
DA 2026-07-24
ER
PT J
AU Labler, L
   Trentz, O
AF Labler, L
   Trentz, O
TI VAC™ instillation:: in vitro model.: Part 2
SO BIOMEDIZINISCHE TECHNIK
LA English
DT Article
DE infected wound; VAC; VAC instillation; vacuum assisted closure
AB The behavior of a liquid in foam in the course of the VA.C.(TM) instillation was investigated in an in vitro model by visualization using an aqueous color solution and by a quantitative determination of changing concentration of Ringerlactate solution.
C1 Univ Zurich Hosp, Div Trauma Surg, Dept Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Labler, L (通讯作者)，Univ Zurich Hosp, Div Trauma Surg, Dept Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM ludwig.labler@usz.ch
CR Fleischmann W, 1998, UNFALLCHIRURG, V101, P649, DOI 10.1007/s001130050318
   *KIN CONC INC, VAC INSTILL
   Labler L, 2005, BIOMED TECH, V50, P413, DOI 10.1515/BMT.2005.058
   TREADWELL WD, 1943, KURZES LEHRBUCH ANAL, P615
NR 4
TC 4
Z9 4
U1 0
U2 0
PU WALTER DE GRUYTER & CO
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0013-5585
J9 BIOMED TECH
JI Biomed. Tech.
PY 2006
VL 51
IS 1
BP 30
EP 37
DI 10.1515/BMT.2006.007
PG 8
WC Engineering, Biomedical; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Medical Informatics
GA 052HY
UT WOS:000238226000006
PM 16771128
OA Green Accepted
DA 2026-07-24
ER
PT J
AU Stannard, JP
   Robinson, JT
   Anderson, ER
   McGwin, G
   Volgas, DA
   Alonso, JE
AF Stannard, James P.
   Robinson, James T.
   Anderson, E. Ratcliffe
   McGwin, Gerald, Jr.
   Volgas, David A.
   Alonso, Jorge E.
TI Negative pressure wound therapy to treat hematomas and surgical
   incisions following high-energy trauma
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE negative pressure wound therapy; hematoma; surgical incisions;
   high-energy trauma
ID VACUUM-ASSISTED CLOSURE; TIBIAL PLATEAU FRACTURES; WIRE EXTERNAL
   FIXATION; SUBATMOSPHERIC PRESSURE; CLINICAL-EXPERIENCE; DEGLOVING
   INJURIES; SKIN-GRAFTS; MANAGEMENT; DRESSINGS; SYSTEM
AB Purpose: To evaluate the use of negative pressure wound therapy (NPWT) to augment healing of surgical incisions and hematomas after high-energy trauma.
   Materials: This study is a prospective randomized evaluation of NPWT in trauma patients, randomizing patients with draining hematomas to either a pressure dressing (group A) or a VAC (group B). Additionally, patients with calcaneus, pilon, and high-energy tibial plateau fractures were randomized to either a standard postoperative dressing or a VAC over the sutures.
   Results: There were 44 patients randomized into the hematoma study. Group A drained a mean of 3.1 days, compared with only 1.6 days for group B. This difference was significant (p = 0.03). The infection rate for group A was 16%, compared with 8% in group B. An additional 44 patients have been randomized into the fracture study. Again, a significant difference (p = 0.02) was present when comparing drainage in group A (4.8 days) and group B (1.8 days). No significant difference was present at current enrollment for infection or wound breakdown.
   Discussion: NPWT has been used on many complex traumatic wounds. Potential mechanisms of action include angiogenesis, increased blood flow, and decreased interstitial fluid. This ongoing randomized study has demonstrated decreased drainage and improved wound healing following both hematomas and severe fractures.
C1 Univ Alabama Birmingham, Div Orthopaed Surg, Dept Surg, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Stannard, JP (通讯作者)，Univ Alabama Birmingham, Div Orthopaed Surg, Dept Surg, 509 Med Educ Bldg,619 S 19th St, Birmingham, AL 35294 USA.
EM James.Stannard@ortho.uab.edu
OI Stannard, James P/0000-0001-8467-6494
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BANWELL P, 2002, EUR TISSUE REPAIR SO, V9, P49
   Banwell P E., 2003, J Wound Care, V12, P28
   Bartlett CS, 2003, SKELETAL TRAUMA BASI, V3rd, P2257
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   BUTTENSCHOEN K, 2000, FOOT ANKLE SURG, V7, P165
   de la Torre Jorge I, 2002, Ostomy Wound Manage, V48, P18
   de Lange MY, 2000, EUR J PLAST SURG, V23, P178, DOI 10.1007/s002380050244
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   DeFranzo AJ, 1999, PLAST RECONSTR SURG, V104, P2145, DOI 10.1097/00006534-199912000-00031
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   FOX MP, 2000, J BONE JOINT SURG BR, V83, P19
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   GREER S, 1997, NURSING STANDARD, V11, P151
   GUSTAFSSON R, 2002, J THORAC CARDIOVASC, V123, P210
   Harvey EJ, 2001, FOOT ANKLE INT, V22, P868, DOI 10.1177/107110070102201102
   Herscovici D, 2003, J ORTHOP TRAUMA, V17, P683, DOI 10.1097/00005131-200311000-00004
   Heugel JR, 2002, J BURN CARE REHABIL, V23, P167, DOI 10.1097/00004630-200205000-00005
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   Morykwas M J, 1997, J South Orthop Assoc, V6, P279
   Morykwas MJ, 2002, J TRAUMA, V53, P537, DOI 10.1097/00005373-200209000-00023
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   MORYKWAS MJ, 1998, WOUND HEALING SOC NE, V8, P4
   REID DJ, 2001, SURG PHYS ASSISTANT, P9
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   STAMER DT, 1994, J ORTHOP TRAUMA, V8, P455, DOI 10.1097/00005131-199408060-00001
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   WONGWORAWAT MD, 2003, CLIN ORTH RELAT RES, V1, P45
   Wu SH, 2000, EUR J PLAST SURG, V23, P174, DOI 10.1007/s002380050243
   Yuan-Innes M. J., 2001, Spine, V26, pE1
NR 44
TC 236
Z9 282
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD JUN
PY 2006
VL 60
IS 6
BP 1301
EP 1306
DI 10.1097/01.ta.0000195996.73186.2e
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 053TR
UT WOS:000238328700032
PM 16766975
DA 2026-07-24
ER
PT J
AU Bütter, A
   Emran, M
   Al-Jazaeri, A
   Ouimet, A
AF Butter, Andreana
   Emran, Mohammad
   Al-Jazaeri, Ayman
   Ouimet, Alain
TI Vacuum-assisted closure for wound management in the pediatric population
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 37th Annual Meeting of the Canadian-Association-of-Paediatric-Surgeons
CY SEP 22-25, 2005
CL Quebec City, CANADA
SP Canadian Assoc Paediat Surg
DE vacuum-assisted closure; wound care; pediatric
ID EXPERIENCE
AB Background/Purpose: Wound management in children has traditionally consisted of daily dressings. Although vacuum-assisted closure (VAC) is well described in the adult literature, there are few reports about children. We reviewed our experience with VAC.
   Methods: A retrospective review from 2003 to 2005 revealed that 16 children underwent VAC. Variables analyzed included demographics, diagnosis, duration and characteristics of VAC, wound closure, recurrence, complications, and cost analysis.
   Results: Sixteen children received VAC therapy at an average age of 12.1 years (range, 1 month -18 years). Indications included tissue loss after pilonidal sinus excision (n = 8, primary = 5, recurrent 3) after wound dehiscence of the abdomen (3), the sternum (2), the back (1), the leg (1), and after chronic postoperative perineal fistula. Average length of VAC use was 23 days, with an average pressure of 104 nun Hg. Wound closure occurred in 15 of 16 patients. Patients with primary pilonidal disease obtained wound closure by 45 days, whereas those with recurrent disease required 72 days. Children with wound dehiscence healed by 28 days. Recurrent sinuses developed in all 3 patients with known recurrent pilonidal disease. Pain in 1 patient required cessation of VAC therapy after 7 days. Follow-up after wound closure averaged 8 months.
   Conclusions: Vacuum-assisted closure is well tolerated in our pediatric population and offers many advantages including fewer dressing changes and an earlier return to daily activities. (c) 2006 Elsevier Inc. All rights reserved.
C1 Hop St Justine, Div Pediat Surg, Montreal, PQ H3T 1C5, Canada.
C3 Universite de Montreal
RP Ouimet, A (通讯作者)，Hop St Justine, Div Pediat Surg, Montreal, PQ H3T 1C5, Canada.
EM amouimet@videotron.ca
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
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   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
NR 8
TC 59
Z9 65
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD MAY
PY 2006
VL 41
IS 5
BP 940
EP 942
DI 10.1016/j.jpedsurg.2006.01.061
PG 3
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Surgery
GA 054PI
UT WOS:000238390700014
PM 16677888
DA 2026-07-24
ER
PT J
AU Ford-Dunn, S
AF Ford-Dunn, Suzanne
TI Use of vacuum assisted closure therapy in the palliation of a malignant
   wound
SO PALLIATIVE MEDICINE
LA English
DT Article
DE malignant wound; palliative care; vacuum assisted closure
ID DEVICE
AB Vacuum assisted closure (VAC) therapy is a novel method of wound healing using topical negative pressure across the wound bed and containing all exudate within a sealed system. We report the use of VAC therapy to control pain and exudate of a malignant wound.
C1 St Barnabas Hosp, Columbia Dr, Worthing, England.
RP Ford-Dunn, S (通讯作者)，St Barnabas Hosp, Columbia Dr, Worthing, England.
EM suzanne.ford.dunn@stbarnabas-hospice.org.uk
OI Ford-Dunn, Suzanne/0009-0003-4444-421X
CR Banwell P E, 1999, J Wound Care, V8, P79
   de Geus HRH, 2005, INTENS CARE MED, V31, P601, DOI 10.1007/s00134-004-2553-5
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Miller M., 1999, Wound Management: Theory And Practice
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Schaffzin DM, 2004, DIS COLON RECTUM, V47, P1745, DOI 10.1007/s10350-004-0633-9
   SMITH N, 2005, BR J NURS, V13, P1359
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Stonerock CE, 2003, AM SURGEON, V69, P1030
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
   White RA, 2005, J ORTHOP TRAUMA, V19, P56, DOI 10.1097/00005131-200501000-00011
NR 11
TC 24
Z9 29
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-2163
EI 1477-030X
J9 PALLIATIVE MED
JI Palliat. Med.
PY 2006
VL 20
IS 4
BP 477
EP 478
DI 10.1191/0269216306pm1117cr
PG 2
WC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; General & Internal Medicine
GA 055GN
UT WOS:000238438300013
PM 16875120
DA 2026-07-24
ER
PT J
AU Nixon, M
   Jackson, B
   Varghese, P
   Jenkins, D
   Taylor, G
AF Nixon, M
   Jackson, B
   Varghese, P
   Jenkins, D
   Taylor, G
TI Methicillin-resistant Staphylococcus aureus on orthopaedic wards
SO JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
LA English
DT Article
ID HIP FRACTURE; RISK-FACTORS; HOSPITAL ADMISSION; SURGICAL PATIENTS;
   INFECTION; MRSA; COLONIZATION; PREVALENCE; BACTEREMIA; MORTALITY
AB We examined the rates of infection and colonisation by methicillin-resistant Staphylococcus aureus (MRSA) between January 2003 and May 2004 in order to assess the impact of the introduction of an MRSA policy in October 2003, which required all admissions to be screened. Emergency admissions were treated prophylactically and elective beds ring-fenced. A total of 5594 admissions were cross-referenced with 22 810 microbiology results. The morbidity, mortality and cost of managing MRSA-carrying patients, with a proximal fracture of the femur were compared, in relation to age, gender, American Society of Anaesthesiologists grade and residential status, with a group of matched controls who were MRSA-negative.
   In 2004, we screened 1795 of 1796 elective admissions and MRSA was found in 23 (1.3%). We also screened 1122 of 1447 trauma admissions and 43 (3.8%) were carrying MRSA. All ten ward transfers were screened and four (40%) were carriers (all p < 0.001). The incidence of MRSA in trauma patients increased by 2.6% per week of inpatient stay (r = 0.97, p < 0.001). MRSA developed in 2.9% of trauma and 0.2% of elective patients during that admission (p < 0.001). The implementation of the MRSA policy reduced the incidence of MRSA infection by 56% in trauma patients (1.57% in 2003 (17 of 1084) to 0.69% in 2004 (10 of 1447), p = 0.035). Infection with MRSA in elective patients was reduced by 70% (0.56% in 2003 (7 of 1257) to 0.17% in 2004 (3 of 1806), p = 0.06). The cost of preventing one MRSA infection was 3200 pound.
   Although colonisation by MRSA did not affect the mortality rate, infection by MRSA more than doubled it. Patients with proximal fractures of the femur infected with MRSA remained in hospital for 50 extra days, had 19 more days of vancomycin treatment and 26 more days of vacuum-assisted closure therapy than the matched controls. These additional costs equated to 13972 pound per patient.
   From this experience we have been able to describe the epidemiology of MRSA, assess the impact of infection-control measures on MRSA infection rates and determine the morbidity, mortality and economic cost of MRSA carriage on trauma and elective orthopaedic wards.
C1 Glenfield Gen Hosp, Dept Traumat & Orthopaed Surg, Leicester LE3 9QP, Leics, England.
   Leicester Royal Infirm, Dept Microbiol, Leicester LE1 5WW, Leics, England.
C3 University Hospitals of Leicester NHS Trust; University of Leicester;
   Glenfield Hospital; University of Leicester
RP Nixon, M (通讯作者)，15 Chelsea Mews, Nottingham NG12 2NT, England.
EM mfnixon@gmail.com
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NR 25
TC 67
Z9 76
U1 0
U2 3
PU BRITISH EDITORIAL SOC BONE JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 0301-620X
J9 J BONE JOINT SURG BR
JI J. Bone Joint Surg.-Br. Vol.
PD JUN
PY 2006
VL 88B
IS 6
BP 812
EP 817
DI 10.1302/0301-620X.88B6
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 055RQ
UT WOS:000238468500022
PM 16720779
DA 2026-07-24
ER
PT J
AU Attinger, CE
   Janis, JE
   Steinberg, J
   Schwartz, J
   Al-Attar, A
   Couch, KA
AF Attinger, Christopher E.
   Janis, Jeffey E.
   Steinberg, John
   Schwartz, Jaime
   Al-Attar, Ali
   Couch, Kara
TI Clinical approach to wounds: Debridement and wound bed preparation
   including the use of dressings and wound-healing adjuvants
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; DERMAL REGENERATION
   TEMPLATE; HYPERBARIC-OXYGEN THERAPY; HUMAN SKIN; SILVER SULFADIAZINE;
   OCCLUSIVE DRESSINGS; SUPERFICIAL WOUNDS; ARTIFICIAL SKIN; TOPICAL
   THERAPY
AB This is a clinical review of current techniques in wound bed preparation found to be effective in assisting the wound-healing process. The process beams with the identification of a correct diagnosis of the wound's etiology and continues with optimizing the patient's medical condition, including blood flow I to the wound site. Debridement as the basis of most wound-healing strategies is then emphasized. Various debridement techniques, including surgery, topical agents, and biosurgery, are thoroughly discussed and illustrated. Wound dressings, including the use of negative pressure wound therapy, are then reviewed. To properly determine the timing of advance therapeutic intervention, the wound-healing progress needs to be monitored carefully with weekly measurements. A reduction in wound area of 10 to 15 percent per week represents normal healing and does not mandate a change in the current wound-healing strategy. However, if this level of wound area reduction is not met consistently on a weekly basis, then alternative healing interventions should be considered. There is a growing body of evidence that can provide guidance on the appropriate use of such adjuvants in the problem wound. Several adjuvants are discussed, including growth factor, bioengineered tissues, and hyperbaric medicine.
C1 Georgetown Univ, Med Ctr, Georgetown Limb Ctr, Washington, DC 20007 USA.
   Univ Texas, Dept Plast Surg, Houston, TX USA.
C3 Georgetown University; University of Texas System
RP Attinger, CE (通讯作者)，Georgetown Univ, Med Ctr, Georgetown Limb Ctr, 1 Main,3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM cattinger@aol.com
RI Janis, Jeffrey/W-6760-2019; Schwartz, Jaime/ISA-3982-2023
OI Janis, Jeffrey/0000-0001-6103-4798; 
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NR 147
TC 220
Z9 253
U1 0
U2 56
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUN
PY 2006
VL 117
IS 7
SU S
BP 72S
EP 109S
DI 10.1097/01.prs.0000225470.42514.8f
PG 38
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 056UA
UT WOS:000238549400008
PM 16799376
DA 2026-07-24
ER
PT J
AU Morykwas, MJ
   Simpson, J
   Punger, K
   Argenta, A
   Kremers, L
   Argenta, J
AF Morykwas, Michael J.
   Simpson, Jordan
   Punger, Kally
   Argenta, Anne
   Kremers, Lieveke
   Argenta, Joseph
TI Vacuum-assisted closure: State of basic research and physiologic
   foundation
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID SUBATMOSPHERIC PRESSURE; TISSUE EXPANSION; WOUND THERAPY; SWINE MODEL;
   SKIN; STRETCH; GROWTH; BURNS
AB A tremendous amount of research has been conducted in recent years investigating the mechanisms of action by which the application of subatmospheric pressure to wounds increases the rate of healing. Similarly, numerous studies have also been conducted examining the physiologic response of wounds to the applied subatmospheric pressure. However, many more need to be conducted. A series of basic studies examining the use of subatmospheric pressure to treat wounds is presented, including the original studies upon which the vacuum-assisted closure device was based (on blood flow, granulation tissue formation, bacterial clearance, and survival of random-pattern pedicle flaps). Subsequent studies analyzing removed fluids, envenomation/extravasation, burns, grafts, and in vitro tissue culture studies are also reviewed. Two broad mechanisms of action are proposed: removal of fluid and mechanical deformation. Fluid removal both decreases edemathus decreasing interstitial pressure and shortening distances of diffusion- and removes soluble factors that may affect the healing process (both positively and negatively). The relationship of mechanical deformation to increased growth is well known to plastic surgeons, as it is the basis of tissue expansion. While much has been done, a great deal more needs to be done to elucidate the mechanisms of action responsible for the dramatic response seen clinically.
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM mmorykwa@wfubmc.edu
OI Morykwas, Michael/0009-0001-5547-5172
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NR 38
TC 311
Z9 374
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUN
PY 2006
VL 117
IS 7
SU S
BP 121S
EP 126S
DI 10.1097/01.prs.0000225450.12593.12
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 056UA
UT WOS:000238549400011
PM 16799379
DA 2026-07-24
ER
PT J
AU Argenta, LC
   Morykwas, MJ
   Marks, MW
   DeFranzo, AJ
   Molnar, JA
   David, LR
AF Argenta, Louis C.
   Morykwas, Michael J.
   Marks, Malcolm W.
   DeFranzo, Anthony J.
   Molnar, Joseph A.
   David, Lisa R.
TI Vacuum-assisted closure: State of clinic art
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID PRESSURE WOUND THERAPY; DIABETIC FOOT WOUNDS; SECURING SKIN-GRAFTS;
   SUBATMOSPHERIC PRESSURE; ABDOMINAL-WALL; POSTSTERNOTOMY MEDIASTINITIS;
   DEGLOVING INJURIES; DEFINITIVE CLOSURE; RANDOMIZED-TRIAL; FASCIAL
   CLOSURE
AB Treatment of wounds has been the cornerstone of plastic surgery since its inception. Vacuum-assisted closure provides a new paradigm that can be used in concert with a wide variety of standard existing plastic surgery techniques. It was originally developed as an alternative treatment for debilitated patients with chronic wounds. It has rapidly evolved into a widely accepted treatment of chronic and acute wounds, contaminated wounds, burns, envenomations, infiltrations, and wound complications from failed operations. The ease of technique and a high rate of success have encouraged its adaptation by thoracic, general, trauma, burn, orthopedic, urologic, as well as plastic surgeons. This article discusses multidisciplinary advances in the use of the vacuum-assisted closure technique over the past 10 years and its status as of 2006. Creative surgeons continue to regularly adapt the system to difficult problems. This technique in trained surgical hands greatly enhances the scope and safety of wound treatment.
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University
RP Argenta, LC (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM largenta@wfubmc.edu
RI ; Molnar, Joseph/AEK-5540-2022
OI Morykwas, Michael/0009-0001-5547-5172; 
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NR 85
TC 228
Z9 281
U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUN
PY 2006
VL 117
IS 7
SU S
BP 127S
EP 142S
DI 10.1097/01.prs.0000222551.10793.51
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 056UA
UT WOS:000238549400012
PM 16799380
DA 2026-07-24
ER
PT J
AU Andros, G
   Armstrong, DG
   Attinger, CE
   Boulton, AJM
   Frykberg, RG
   Joseph, WS
   Lavery, LA
   Morbach, S
   Niezgoda, JA
   Toursarkissian, B
AF Andros, George
   Armstrong, David G.
   Attinger, Christopher E.
   Boulton, Andrew J. M.
   Frykberg, Robert G.
   Joseph, Warren S.
   Lavery, Lawrence A.
   Morbach, Stephan
   Niezgoda, Jeffrey A.
   Toursarkissian, Boulos
TI Consensus statement on negative pressure wound therapy (VAC® therapy)
   for the management of diabetic foot wounds
SO OSTOMY WOUND MANAGEMENT
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE;
   MAJOR AMPUTATION; TISSUE EXPANSION; RANDOMIZED-TRIAL; RISK-FACTORS;
   ULCERATION; CARE; OUTCOMES
AB In 2004, a multidisciplinary expert panel convened at the Tucson Expert Consensus Conference (TECC) to determine appropriate use of negative pressure wound therapy as delivered by a Vacuum Assisted Closure(R) device (V.A.C.(R) Therapy, KCI, San Antonio, Tex) in the treatment of diabetic foot wounds. These guidelines were updated by a second multidisciplinary expert panel at a consensus conference on the use of V.A.C.(R) Therapy, held in February 2006, in Miami, Florida. This updated version of the guidelines summarizes current clinical evidence, provides practical guidance, offers best practices to clinicians treating diabetic foot wounds, and helps direct future research.
   The Miami consensus panel discussed the following 12 key questions regarding V.A.C.(R) Therapy: 1) How long should V.A.C.(R) Therapy be used in the treatment of a diabetic foot wound? 2) Should V.A.C.(R) Therapy be applied without debriding the wound? 3) How should the patient using V.A.C.(R) Therapy be evaluated on an outpatient basis? 4) When should V.A.C.(R) Therapy be applied following revascularization? 5) When should V.A.C.(R) Therapy be applied after incision, drainage, and debridement of infection? 6) Should V.A.C.(R) Therapy be applied over an active soft tissue infection? 7) How should V.A.C.(R) Therapy be used in patients with osteomyelitis? 8) How should noncompliance to V.A.C.(R) Therapy be defined? 9) How should V.A.C.(R) Therapy be used in combination with other modalities? 10) Should small, superficial wounds be considered for V.A.C.(R) Therapy? 11) How should success in the use of V.A.C.(R) Therapy be defined? 12) How can one combine effective offloading and V.A.C.(R) Therapy?
RI ; Niezgoda, Jeffrey/KZU-8352-2024
OI Morbach, Stephan/0000-0001-5498-1519; Lavery,
   Lawrence/0000-0002-7920-9952; 
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NR 145
TC 53
Z9 67
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2006
SU S
BP 1
EP 32
PG 32
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 061ER
UT WOS:000238854500001
DA 2026-07-24
ER
PT J
AU Hurnburg, J
   Holzgreve, W
   Hoesli, I
AF Humburg, Joerg
   Holzgreve, Wolfgang
   Hoesli, Irene
TI Negative pressure wound therapy in post-cesarean superficial wound
   disruption: A report of 3 cases
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID CESAREAN DELIVERY; CLOSURE
AB Wound disruption after cesarean section is a common complication that may cause additional stress postpartum. The treatment options are secondary closure with the risk of reinfection or healing by secondary intention. In some cases, negative pressure wound therapy can be a useful alternative. Three cases of superficial wound disruption after cesarean section performed for failure to progress are presented. Successful closure with negative pressure wound therapy was achieved after conventional surgical treatment options were exhausted or unacceptable to the patients. Negative pressure wound therapy is a safe, feasible, and well-tolerated treatment option.
C1 Univ Womens Hosp, Dept Obstet & Gynaecol, CH-4031 Basel, Switzerland.
RP Hurnburg, J (通讯作者)，Univ Womens Hosp, Dept Obstet & Gynaecol, Spitalstr 21, CH-4031 Basel, Switzerland.
EM jhumburg@uhbs.ch
CR Chelmow D, 2004, OBSTET GYNECOL, V103, P974, DOI 10.1097/01.AOG.0000124807.76451.47
   DODSON MK, 1992, OBSTET GYNECOL, V80, P321
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   WALTERS MD, 1990, OBSTET GYNECOL, V76, P597
NR 6
TC 6
Z9 6
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2006
VL 18
IS 6
BP 166
EP 169
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 061FY
UT WOS:000238857900006
DA 2026-07-24
ER
PT J
AU Petzina, R
   Gustafsson, L
   Mokhtari, A
   Ingemansson, R
   Malmsjö, M
AF Petzina, Rainer
   Gustafsson, Lotta
   Mokhtari, Arash
   Ingemansson, Richard
   Malmsjo, Malin
TI Effect of vacuum-assisted closure on blood flow in the peristernal
   thoracic wall after internal mammary artery harvesting
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE animal model; experimental surgery; mediastinal infection; vascular tone
   and reactivity; wound healing
ID WOUND CONTROL; MEDIASTINITIS; EXPERIENCE; INFECTION; THERAPY; STRESS;
   DEEP
AB Objective: Vacuum-assisted closure (VAC) is a recently introduced method for the treatment of poststernotomy mediastinitis. The aim was to examine the effects of VAC negative pressure on peristernal soft tissue, blood flow after internal mammary artery harvesting. Methods: Microvascular blood flow was measured using laser Doppler velocimetry in a porcine sternotomy wound model. The effect of VAC negative pressure on blood flow to the wound edge was investigated on the right side, where the internal mammary artery was intact, and on the left side, where the internal mammary artery had been removed. Results: Before removal of the left internal mammary artery, the blood flow was similar in the right and left peristernal wound edges, 2.5 cm from the edge (27 +/- 4 perfusion units (PU) on the right side and 32 +/- 3 PU on the left side, in muscle tissue). When the left internal mammary artery was surgically removed, the blood flow on the left side decreased (19 3 PU, in muscle tissue), while the skin blood flow was not affected. VAC negative pressure induced an immediate increase in wound edge blood flow both on the right side (43 +/- 9 PU, in muscle tissue at -75 mmHg), where the internal mammary artery was intact, and on the left side, where the internal mammary artery had been removed (49 11 PU, in muscle tissue at -75 mmHg). The increase in blood flow was similar on both sides at -75 mmHg and at -125 mmHg. Conclusions: The peristernal wound edge microvascular blood flow is decreased when the left internal mammary artery is removed. VAC therapy stimulates blood flow in the peristernal thoracic wall after internal mammary artery harvesting. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，Lund Univ, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
OI Maljö, Malin/0000-0001-9849-9599; Gustafsson, Lotta/0000-0002-9826-9133;
   Ingemansson, Richard/0000-0001-7623-8953; Petzina,
   Rainer/0000-0002-0688-5482
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NR 20
TC 66
Z9 88
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD JUL
PY 2006
VL 30
IS 1
BP 85
EP 89
DI 10.1016/j.ejcts.2006.04.009
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 062GP
UT WOS:000238932900020
PM 16730446
DA 2026-07-24
ER
PT J
AU Gibbs, S
   van den Hoogenband, HM
   Kirtschig, G
   Richters, CD
   Spiekstra, SW
   Breetveld, M
   Scheper, RJ
   de Boer, EM
AF Gibbs, S.
   van den Hoogenband, H. M.
   Kirtschig, G.
   Richters, C. D.
   Spiekstra, S. W.
   Breetveld, M.
   Scheper, R. J.
   de Boer, E. M.
TI Autologous full-thickness skin substitute for healing chronic wounds
SO BRITISH JOURNAL OF DERMATOLOGY
LA English
DT Article
DE autologous; inert ulcer; skin substitute; wound healing
ID DIABETIC FOOT ULCERS; VENOUS LEG ULCERS; FIBROBLASTS; KERATINOCYTES;
   FUTURE; GROWTH
AB Chronic wounds represent a major problem to our society. Therefore, advanced wound-healing strategies for the treatment of these wounds are expanding into the field of tissue engineering.
   To develop a novel tissue-engineered, autologous, full-thickness skin substitute of entirely human origin and to determine its ability to heal chronic wounds.
   Skin substitutes (fully differentiated epidermis on fibroblast-populated human dermis) were constructed from 3-mm punch biopsies isolated from patients to be treated. Acellular allodermis was used as a dermal matrix. After a prior 5-day vacuum-assisted closure therapy to prepare the wound bed, skin substitutes were applied in a simple one-step surgical procedure to 19 long-standing recalcitrant leg ulcers (14 patients; ulcer duration 0.5-50 years).
   The success rate in culturing biopsies was 97%. The skin substitute visibly resembled an autograft. Eleven of the 19 ulcers (size 1-10 cm(2)) healed within 8 weeks after a single application of the skin substitute. The other eight larger (60-150 cm(2)) and/or complicated ulcers healed completely (n = 5) or continued to decrease substantially in size (n = 3) after the 8-week follow-up period. Wound healing occurred by direct take of the skin substitute (n = 12) and/or stimulation of granulation tissue/epithelialization (n = 7). Skin substitutes were very well tolerated and pain relief was immediate after application.
   Application of this novel skin substitute provides a promising new therapy for healing chronic wounds resistant to conventional therapies.
C1 Free Univ Amsterdam, Dept Dermatol, NL-1081 HV Amsterdam, Netherlands.
   Free Univ Amsterdam, Dept Pathol, NL-1081 HV Amsterdam, Netherlands.
   Euro Skin Bank, Beverwijk, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Gibbs, S (通讯作者)，Free Univ Amsterdam, Dept Dermatol, NL-1081 HV Amsterdam, Netherlands.
EM s.gibbs@vumc.nl
RI spiekstra, sw/J-8957-2012; Richters, Cornelia/KIA-2309-2024
OI spiekstra, sw/0000-0002-8178-5318; 
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NR 28
TC 66
Z9 80
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-0963
EI 1365-2133
J9 BRIT J DERMATOL
JI Br. J. Dermatol.
PD AUG
PY 2006
VL 155
IS 2
BP 267
EP 274
DI 10.1111/j.1365-2133.2006.07266.x
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 063FK
UT WOS:000239003000002
PM 16882162
DA 2026-07-24
ER
PT J
AU Motomura, H
   Ohashi, N
   Harada, T
   Muraoka, M
   Ishii, M
AF Motomura, Hisashi
   Ohashi, Natsuko
   Harada, Teruichi
   Muraoka, Michinari
   Ishii, Masaiiiitsu
TI Aggressive conservative therapy for refractory ulcer with diabetes
   and/or arteriosclerosis
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE arteriosclerosis; diabetes; foot ulcer; trafermin; vacuum-assisted
   closure therapy
ID VACUUM-ASSISTED CLOSURE; LIMB SALVAGE; LOWER-EXTREMITY; EXPERIENCE; FOOT
AB A foot ulcer due to diabetes and/or arteriosclerosis obliterans (ASO) frequently results in an intractable condition that resists treatment. To cope with this condition, we have developed a combination therapy that includes conventional conservative therapy plus surgical therapy. This aggressive conservative therapy using aggressive debridement, trafermin (Fiblast Spray, Kaken, Japan) treatment and vacuum-assisted closure (VAC) therapy was adopted to treat seven patients suffering from diabetes and ASO-related refractory foot ulcer accompanied by bone exposure. With the exception of one patient who died during the treatment, the remaining six patients obtained limb salvage. The mean time to cure was 8.3 months. This approach should be considered before amputation. Some patients may refuse amputation or cannot tolerate highly invasive surgical treatment including tissue transplantation. In such cases, this aggressive conservative therapy can be employed as a highly useful and reproducible technique requiring simple techniques.
C1 Osaka City Univ, Grad Sch Med, Dept Plast & Reconstruct Surg, Abeno Ku, Osaka 5458585, Japan.
   Osaka City Univ, Grad Sch Med, Dept Dermatol, Abeno Ku, Osaka 5458585, Japan.
C3 Osaka Metropolitan University; Osaka Metropolitan University
RP Motomura, H (通讯作者)，Osaka City Univ, Grad Sch Med, Dept Plast & Reconstruct Surg, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan.
EM motoniura@med.osaka-cu.ac.jp
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   CHOWDARY RP, 1991, PLAST RECONSTR SURG, V87, P529, DOI 10.1097/00006534-199103000-00021
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   Ichioka S, 2005, J Wound Care, V14, P105
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   SERLETTI JM, 1995, PLAST RECONSTR SURG, V96, P1136, DOI 10.1097/00006534-199510000-00022
NR 7
TC 5
Z9 6
U1 0
U2 3
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0385-2407
J9 J DERMATOL
JI J. Dermatol.
PD MAY
PY 2006
VL 33
IS 5
BP 353
EP 359
DI 10.1111/j.1346-8138.2006.00082.x
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 063NU
UT WOS:000239027300008
PM 16700669
OA Bronze
DA 2026-07-24
ER
PT J
AU Bui, TD
   Huerta, S
   Gordon, IL
AF Bui, Trung D.
   Huerta, Sergio
   Gordon, Ian L.
TI Negative pressure wound therapy with off-the-shelf components
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE negative pressure therapy; wound; skin graft; vacuum assisted closure;
   off-the-shelf system
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE; MANAGEMENT; PACK
AB Background: The KCI Wound VAC system (Kinetic Concepts, Inc, San Antonio, TX) for providing negative-pressure therapy for wounds is expensive and may not be available for patients without insurance. We have examined the feasibility of using off-the-shelf components to provide comparable negative pressure therapy at less cost.
   Methods: Adhesive iodine-impregnated drape, a flat Jackson-Pratt drain (Cardinal Health, McGaw Park, IL), and foam prep sponges stapled together are used to assemble a dressing connected to wall suction (negative 75-100 mm Hg) to create negative pressure wound therapy that is relatively inexpensive (<$60 component cost).
   Results: We have used this system in more than 40 cases with results that seem comparable to the commercial system and have not seen bleeding or other complications.
   Conclusion: Off-the-shelf components can be safely employed to provide effective negative pressure therapy for wounds and skin grafts. (c) 2006 Excerpta Medica Inc. All rights reserved.
C1 VA Long Beach Healthcare Syst, Dept Vasc Surg, Long Beach, CA USA.
   UCI, Med Ctr, Dept Vasc & Endovasc Surg, Orange, CA 92868 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Long Beach Healthcare System; University of California System;
   University of California Irvine
RP Bui, TD (通讯作者)，VA Long Beach Healthcare Syst, Dept Vasc Surg, Long Beach, CA USA.
EM buitd@uci.edu
RI Huerta, Sergio/G-3699-2013
OI Huerta, Sergio/0000-0001-7720-419X
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BROCK WB, 1995, AM SURGEON, V61, P30
   Carson Stanley N, 2004, Ostomy Wound Manage, V50, P52
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   KOSTIUCHENOK BM, 1986, VESTN KHIR IM GREKOV, V137, P18
   Kovacs LH, 2001, ANN PLAS SURG, V47, P680, DOI 10.1097/00000637-200112000-00022
   McGuinness JG, 2003, DIS COLON RECTUM, V46, P274, DOI 10.1007/s10350-004-6535-z
   Miller PR, 2002, J TRAUMA, V53, P843, DOI 10.1097/00005373-200211000-00007
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Smith LA, 1997, AM SURGEON, V63, P1102
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 16
TC 22
Z9 40
U1 0
U2 2
PU EXCERPTA MEDICA INC
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD AUG
PY 2006
VL 192
IS 2
BP 235
EP 237
DI 10.1016/j.amjsurg.2006.01.013
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 071EK
UT WOS:000239580900017
PM 16860636
DA 2026-07-24
ER
PT J
AU Cothren, CC
   Moore, EE
   Johnson, JL
   Moore, JB
   Burch, JM
AF Cothren, C. Clay
   Moore, Ernest E.
   Johnson, Jeffrey L.
   Moore, John B.
   Burch, Jon M.
TI One hundred percent fascial approximation with sequential abdominal
   closure of the open abdomen
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE open abdomen; trauma; damage control surgery; abdominal compartment
   syndrome; closure
ID VACUUM PACK TECHNIQUE; VENTRAL HERNIA
AB Background: Damage-control surgery and the recognition of the abdominal compartment syndrome have improved patient outcomes but at the cost of an open abdomen. Multiple techniques have been introduced to obtain fascial closure for the open abdomen to minimize morbidity and cost of care. We performed a modification of the vacuum-assisted closure (VAC) technique that provided constant fascial tension, hypothesizing this would result in a higher rate of primary fascial closure.
   Methods:. After initial temporary closure of the abdomen after post-injury damage control or decompressive laparotomy for abdominal compartment syndrome, we began the sequential closure technique. The technique begins by covering the bowel with the multiple white sponges overlapped like patchwork, and the fascia is placed under moderate tension over the white sponges with #1-PDS sutures. Large black VAC sponges are placed on top of the white sponges and affixed with an occlusive dressing and standard suction tubing is placed. Patients are returned to the operating room for sequential fascial closure and replacement of the sponge sandwich every 2 days, with a resulting decrease in the fascial defect.
   Results: Fourteen patients underwent sequential abdominal closure during,the study period: 9 owing to damage control surgery and 5 owing to secondary abdominal compartment syndrome. Average time to closure was 7.5 +/- 1.0 days (range 4-16) and average number of laparotomies to closure was 4.6 +/- 0.5 (range 3-8). All patients attained primary fascial closure.
   Conclusion: We propose a modification of the previously described vacuum-assisted closure technique that achieves 100% fascial approximation in our limited experience. Further application and refinement of this technique may eliminate the need for delayed complex and costly reconstructive abdominal wall procedures for the open abdomen. (c) 2006 Excerpta Medica Inc. All rights reserved.
C1 Denver Hlth Med Ctr, Dept Surg, Denver, CO 80204 USA.
   Univ Colorado, Hlth Sci Ctr, Denver, CO USA.
C3 Denver Health Medical Center; University of Colorado System; University
   of Colorado Anschutz; University of Colorado Denver
RP Cothren, CC (通讯作者)，Denver Hlth Med Ctr, Dept Surg, 777 Bannock St,MC 0206, Denver, CO 80204 USA.
EM clay.cothren@dhha.org
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Cipolla J, 2005, AM SURGEON, V71, P202
   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
   Miller PR, 2002, J TRAUMA, V53, P843, DOI 10.1097/00005373-200211000-00007
   Navsaria PH, 2003, BRIT J SURG, V90, P718, DOI 10.1002/bjs.4101
   Scott BG, 2005, SCAND J SURG, V94, P9, DOI 10.1177/145749690509400104
   Stonerock CE, 2003, AM SURGEON, V69, P1030
   Suliburk JW, 2003, J TRAUMA, V55, P1155, DOI 10.1097/01.TA.0000100218.03754.6A
   Tremblay LN, 2001, AM J SURG, V182, P670, DOI 10.1016/S0002-9610(01)00805-4
NR 9
TC 127
Z9 137
U1 0
U2 4
PU EXCERPTA MEDICA INC
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD AUG
PY 2006
VL 192
IS 2
BP 238
EP 242
DI 10.1016/j.amjsurg.2006.04.010
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 071EK
UT WOS:000239580900018
PM 16860637
DA 2026-07-24
ER
PT J
AU Braakenburg, A
   Obdeijn, MC
   Feitz, R
   van Rooij, IALM
   van Griethuysen, AJ
   Klinkenbijl, JHG
AF Braakenburg, Assa
   Obdeijn, Miryam C.
   Feitz, Reinier
   van Rooij, Iris A. L. M.
   van Griethuysen, Arjanne J.
   Klinkenbijl, Jean H. G.
TI The clinical efficacy and cost effectiveness of the vacuum-assisted
   closure technique in the management of acute and chronic wounds: A
   randomized controlled trial
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 14th Annual Meeting of the Wound-Healing-Society
CY MAY 24, 2004
CL Atlanta, GA
SP Wound Healing Soc
ID SUBATMOSPHERIC PRESSURE; SURGICAL-PROCEDURES; NEGATIVE-PRESSURE;
   THERAPY; EXPERIENCE; SYSTEM
AB Background: Vacuum-assisted closure therapy is a relatively new concept described in the literature that increases wound-healing capacity. The authors aimed to investigate the effect of vacuum-assisted closure therapy on wound healing, granulation tissue formation, bacterial clearance, pain, time involvement of the staff, and total costs in all types of wounds in comparison with modern wound dressings.
   Methods: Sixty-five patients with a chronic or acute wound were randomized to initial treatment with vacuum-assisted closure or modern dressings. The authors' primary endpoint was a granulated wound or a wound ready for skin grafting or healing by secondary intention.
   Results: The time to the primary endpoint with vacuum-assisted closure therapy was not significantly shorter, except for patients with cardiovascular disease and/or diabetics. Vacuum-assisted closure therapy did not result in significantly faster granulation or wound surface reduction or better bacterial clearance, but patient comfort was an important advantage. Time involvement and costs of nursing staff were significantly lower for the vacuum-assisted closure therapy, but overall costs were similar for both groups.
   Conclusions: With vacuum-assisted closure therapy, wound healing is at least as fast as with modern wound dressings. Especially cardiovascular and diabetic patients benefit from this therapy. The total costs of vacuum-assisted closure are comparable to those of modern wound dressings, but the advantage is its comfort for patients and nursing staff.
C1 Rijnstate Hosp, Dept Surg, NL-6800 TA Arnhem, Netherlands.
   Rijnstate Hosp, Dept Res, NL-6800 TA Arnhem, Netherlands.
   Rijnstate Hosp, Dept Med Microbiol & Med Immunol, NL-6800 TA Arnhem, Netherlands.
   Univ Groningen Hosp, Dept Plast & Reconstruct Surg, Groningen, Netherlands.
   Univ Utrecht, Med Ctr, Dept Plast & Reconstruct Surg, Utrecht, Netherlands.
C3 Rijnstate Hospital; Rijnstate Hospital; Rijnstate Hospital; University
   of Groningen; Utrecht University
RP Klinkenbijl, JHG (通讯作者)，Rijnstate Hosp, Dept Surg, Postal Code 9555, NL-6800 TA Arnhem, Netherlands.
EM jklinkenbijl@alysis.nl
RI van Rooij, Iris/A-5705-2014
OI van Rooij, Iris/0000-0002-9519-966X; Feitz, Reinier/0000-0001-6043-2057
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Attinger C E, 2001, Foot Ankle Clin, V6, P627, DOI 10.1016/S1083-7515(02)00010-4
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NR 23
TC 243
Z9 292
U1 0
U2 34
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD AUG
PY 2006
VL 118
IS 2
BP 390
EP 397
DI 10.1097/01.prs.0000227675.63744.af
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 072LM
UT WOS:000239674900018
PM 16874208
DA 2026-07-24
ER
PT J
AU Oetting, P
   Rau, B
   Schlag, PM
AF Oetting, P.
   Rau, B.
   Schlag, P. M.
TI Abdominal vacuum device with open abdomen
SO CHIRURG
LA German
DT Article
DE open abdomen; temporary abdominal closure; vacuum-assisted fascial
   closure; peritonitis; abdominal compartment syndrome; necrotising
   fasciitis
ID ASSISTED FASCIAL CLOSURE; COMPARTMENT SYNDROME; TRAUMA PATIENTS; VENTRAL
   HERNIA; DAMAGE CONTROL; PACK TECHNIQUE; MANAGEMENT
AB Background. For the treatment of peritonitis or abdominal compartment syndrome, an open abdomen can be required. Because of the high complication rate associated with this method, different technical modifications were developed that are now being applied. Abdominal vacuum-assisted closure is increasingly favoured. We analyse our experience with this device in a distinct group of patients from gastrointestinal cancer surgery.
   Patients and method. From June 2003 to December 2005, 36 patients were treated with 151 double-layer abdominal vacuum devices. Indications for applying this device were peritonitis (n=22), abdominal compartment syndrome (n=11), and necrotising fasciitis (n=3). Thirty-four patients gave anamneses of malignoma.
   Results. Overall, the vacuum therapy treatment lasted a median of 13 days (range 348). With it, four enteric fistulas (11%) and four abdominal wall bleedings (11%) occurred. In our patient group, no new intra-abdominal abscesses were observed. Four patients died during treatment with the vacuum-assisted device and four afterward because of multiple organ failure in acute sepsis (in-hospital mortality 22%). Twenty-six patients (72%) underwent direct fascial closure after a median treatment duration of 10 days. Six patients (17%) required synthetic mesh for fascial closure. After a median follow-up of 100 days, two patients developed ventral hernias and two others showed ossification of the scar.
   Conclusion. Compared with other methods of temporary abdominal closure, our experience with the vacuum-assisted device demonstrates its advantages concerning clinical feasibility and the relatively low complication rate. The high rate of direct fascial closure with an acceptable rate of ventral hernias following vacuum-assisted abdominal closure are further benefits of this technique.
C1 Univ Med Berlin, Klin Chirurg & Chirurg Onkol, Robert Rossle Klin Helios Klinikum, D-13125 Berlin, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Helios Kliniken
RP Schlag, PM (通讯作者)，Univ Med Berlin, Klin Chirurg & Chirurg Onkol, Robert Rossle Klin Helios Klinikum, Lindenberger Weg 80,Charite Campus Buch, D-13125 Berlin, Germany.
EM pmschlag@charite.de
RI Rau, Beate/JBS-6713-2023
OI Rau, Beate/0000-0001-5820-6907
CR Adkins AL, 2004, AM SURGEON, V70, P137
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NR 30
TC 20
Z9 20
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD JUL
PY 2006
VL 77
IS 7
BP 586
EP +
DI 10.1007/s00104-006-1200-9
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 074RP
UT WOS:000239829800003
PM 16788732
DA 2026-07-24
ER
PT J
AU Segers, P
   de Jong, AP
   Kloek, JJ
   van der Horst, CM
   Spanjaard, L
   de Mol, BA
AF Segers, P.
   de Jong, A. P.
   Kloek, J. J.
   van der Horst, C. M.
   Spanjaard, L.
   de Mol, B. A.
TI Topical negative pressure therapy in wounds after cardiothoracic
   surgery: Successful experience supported by literature
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE cardiovascular surgery; thoracic surgery; heart valve surgery; coronary
   bypass surgery
ID VACUUM-ASSISTED CLOSURE
AB Background: Patients undergoing cardiothoracic surgery are at substantial risk of developing surgical site infections (SSI). SSI is not only associated with an increased morbidity but also with high mortality. Topical negative pressure therapy (TNP) is a promising method for treating surgical site defects (SSD). In recent years, we have gained a wide experience with TNP in a great variety of SSD. Methods: We completed a prospective follow-up report of all patients treated with TNP after cardiothoracic surgery at the Academic Medical Centre Amsterdam, a university hospital. A review of the current evidence for TNP in cardiothoracic surgery is present. Results: Between August 2000 and March 2005, TNP was used in 105 patients in 113 SSD. As we gained more experience, we saw a decline in hospital stay (p < 0.0001) and duration of TNP therapy. Surgical closure was performed in 62% of patients using simple surgical (reconstructive) techniques. Therapy-related complications were rare (n = 1). Conclusion: Based on clinical findings and supported by the research presented, the treatment modality of choice for SSD after cardiothoracic surgery is TNP.
C1 Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, NL-1105 AZ Amsterdam, Netherlands.
   Univ Amsterdam, Acad Med Ctr, Dept Plast & Reconstruct Surg, NL-1105 AZ Amsterdam, Netherlands.
   Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam; University of
   Amsterdam; Academic Medical Center Amsterdam
RP Segers, P (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM p.segers@amc.uva.nl
RI Segers, Patrick/IWM-4183-2023; Spanjaard, Lodewijk/ODL-4262-2025
OI van der Horst, chantal/0000-0002-4937-3786; de Mol,
   Bastian/0000-0001-6888-9430
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Chester DL, 2002, BRIT J PLAST SURG, V55, P510, DOI 10.1054/bjps.2002.3890
   Conquest AM, 2003, J SURG RES, V115, P209, DOI 10.1016/S0022-4804(03)00331-7
   DELANGE MY, 2004, 2 WORLD UN WOUND HEA
   Dersch T, 1994, 4 ANN M WOUND HEAL S
   Doss M, 2002, EUR J CARDIO-THORAC, V22, P934, DOI 10.1016/S1010-7940(02)00594-8
   Evans D, 2001, BRIT J PLAST SURG, V54, P238, DOI 10.1054/bjps.2001.3547
   Fuchs U, 2005, ANN THORAC SURG, V79, P526, DOI 10.1016/j.athoracsur.2004.08.032
   Gwan-Nulla DN, 2001, ANN PLAS SURG, V47, P552, DOI 10.1097/00000637-200111000-00014
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P249, DOI 10.1097/00003086-198901000-00038
   KOPP J, 2003, WOUND REPAIR REGEN, V11, pA34
   KREMERS L, 2003, WOUND REPAIR REGEN, V11, pA34
   KREMERS L, 2003, EUR TISS REP SOC FOC
   Kutschka I, 2004, ZBL CHIR, V129, pS33, DOI 10.1055/s-2004-822607
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   LIU PH, 2004, J BURN CARE REHABIL, V25, pS52
   Luckraz H, 2003, J THORAC CARDIOV SUR, V125, P301, DOI 10.1067/mtc.2003.74
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Moues C M, 2005, J Wound Care, V14, P224
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   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   SCHULTZ G, 2004, 2 WORLD UN WOUND HEA
   Segers Patrique, 2005, Interact Cardiovasc Thorac Surg, V4, P555, DOI 10.1510/icvts.2005.112714
   Shi W, 2003, SURF ENG, V19, P279, DOI [10.1179/026708403322499209, 10.1179/026708403225006221]
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   SWAN MC, 2003, EUR TISS REP SOC FOC
   Tang Su-yang, 2004, Zhonghua Zheng Xing Wai Ke Za Zhi, V20, P139
   TANG SY, 2005, ZHONGGHUO LINCHUANG, V9, P146
   TEOT L, 2004, 2 WORLD UN WOUND HEA
   VANWIJK MP, 2003, EUR TISS REP SOC FOC
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
   Webb LX, 2001, UNFALLCHIRURG, V104, P918, DOI 10.1007/PL00002776
   White RA, 2005, J ORTHOP TRAUMA, V19, P56, DOI 10.1097/00005131-200501000-00011
   ZOECH G, 2004, 2 WORLD UN WOUND HEA
NR 38
TC 9
Z9 9
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD AUG
PY 2006
VL 54
IS 5
BP 289
EP 294
DI 10.1055/s-2006-924003
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 075QM
UT WOS:000239900300001
PM 16902874
DA 2026-07-24
ER
PT J
AU Mokhtari, A
   Petzina, R
   Gustafsson, L
   Sjögren, J
   Malmsjö, M
   Ingemansson, R
AF Mokhtari, Arash
   Petzina, Rainer
   Gustafsson, Lotta
   Sjogren, Johan
   Malmsjo, Malin
   Ingemansson, Richard
TI Sternal stability at different negative pressures during vacuum-assisted
   closure therapy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID MEDIASTINITIS; INFECTIONS
AB Background. Vacuum-assisted closure (VAC) is a widely used therapy in patients with poststernotomy mediastinitis. The aim of this study was to evaluate sternal stability during VAC application at seven negative pressures (-50 to -200 mm Hg) in a porcine wound model.
   Methods. Six pigs underwent median sternotomy and 2 steel wires were fixed at each sternal side and connected to a traction device. The device was connected to a force transducer linked to a force recorder. VAC therapy was applied to the wound. At each negative pressure, the length and width of the wound were measured before and after traction was started. Traction was increased stepwise up to 400 N.
   Results. The diastasis induced by a certain lateral force was similar in wounds treated with -75, -125, and -175 mm Hg. At -75 mm Hg, a significant improvement (p < 0.01) in sternal stability was seen compared with the open-chest setting. This was not further improved at -125 or -175 mm Hg. High negative pressures (-150 to -200 mm Hg) in combination with a high lateral force (> 200 N) increased the risk of separation of the foam from the wound edges, with air leakage or organ rupture as a result.
   Conclusions. Our results suggest that low negative pressures (-50 to -100 mm Hg) stabilize the sternum as efficiently as high negative pressures (-150 to -200 mm Hg). Low negative pressures (-50 to -100 mm Hg) were more beneficial, however, because no air leakage or organ rupture was observed at these pressures.
C1 Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Internal Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Mokhtari, A (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM arash.mokhtari@med.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021
OI Gustafsson, Lotta/0000-0002-9826-9133; Maljö, Malin/0000-0001-9849-9599;
   Petzina, Rainer/0000-0002-0688-5482; Ingemansson,
   Richard/0000-0001-7623-8953
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Fleck TM, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00189-9
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Luckraz H, 2003, J THORAC CARDIOV SUR, V125, P301, DOI 10.1067/mtc.2003.74
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   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
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NR 17
TC 34
Z9 43
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD SEP
PY 2006
VL 82
IS 3
BP 1063
EP 1067
DI 10.1016/j.athoracsur.2006.04.085
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 076ZD
UT WOS:000239996300045
PM 16928538
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Sartipy, U
   Lockowandt, U
   Gäbel, J
   Jidéus, L
   Dellgren, G
AF Sartipy, Ulrik
   Lockowandt, Ulf
   Gabel, Jakob
   Jideus, Lena
   Dellgren, Goran
TI Cardiac rupture during vacuum-assisted closure therapy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
AB Vacuum-assisted closure therapy is a recently introduced technique for treatment of deep sternal wound infections after cardiac surgery. We present five cases of vacuumassisted closure therapy-related major bleeding complications due to rupture of the right ventricle. This potentially lethal complication may be avoided by covering the heart with protective layers of paraffin gauze dressings.
C1 Karolinska Univ Hosp, Dept Cardiothorac Surg & Anesthesiol, Karolinska Inst, SE-17176 Stockholm, Sweden.
   Sahlgrens Univ Hosp, Dept Cardiothorac Surg, S-41345 Gothenburg, Sweden.
   Univ Uppsala Hosp, Dept Cardiothorac Surg, Uppsala, Sweden.
C3 Karolinska Institutet; Karolinska University Hospital; Sahlgrenska
   University Hospital; Uppsala University; Uppsala University Hospital
RP Sartipy, U (通讯作者)，Karolinska Univ Hosp, Dept Cardiothorac Surg & Anesthesiol, Karolinska Inst, SE-17176 Stockholm, Sweden.
EM ulrik.sartipy@karolinska.se
RI Sartipy, Ulrik/E-9780-2014
OI Sartipy, Ulrik/0000-0003-2707-0263
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   Cowan KN, 2005, ANN THORAC SURG, V80, P2205, DOI 10.1016/j.athoracsur.2005.04.005
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
NR 4
TC 66
Z9 81
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD SEP
PY 2006
VL 82
IS 3
BP 1110
EP 1111
DI 10.1016/j.athoracsur.2006.01.060
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 076ZD
UT WOS:000239996300060
PM 16928555
DA 2026-07-24
ER
PT J
AU Giacalone, PL
   El Gareh, N
   Rihaoui, S
   Giovannini, U
AF Giacalone, Pierre-Ludovic
   El Gareh, Nouredine
   Rihaoui, Samia
   Giovannini, Uberto
TI Transverse rectus abdominis myocutaneous flap wound-healing
   complications in breast reconstruction: Assisted closure using foam
   suction dressing
SO BREAST JOURNAL
LA English
DT Article
DE foam suction dressing; TRAM flap; wound complication
ID NEGATIVE-PRESSURE; EXPERIENCE; THERAPY; PROMOTE; TRIAL
AB Transverse rectus abdominis myocutaneous (TRAM) flap necrosis is a difficult reconstructive problem which historically has entailed protracted management with poor aesthetic outcome. The use of a foam suction dressing achieves effective delayed primary closure of the flap wound with an acceptable aesthetic result. The results of using a vacuum-assisted closure (VAC) system were examined in three patients. The VAC system was found to be safe and effective in facilitating the closure of large and complex wounds without skin grafting. This option should thus be given serious consideration in some difficult wound healing situations.
C1 Hop Arnaud de Villeneuve, Dept Obstet & Gynecol, F-34295 Montpellier 5, France.
   Hop Lapeyronie, Burn Unit, Montpellier, France.
C3 Universite de Montpellier; CHU de Montpellier; Universite de
   Montpellier; CHU de Montpellier
RP Giacalone, PL (通讯作者)，Hop Arnaud de Villeneuve, Dept Obstet & Gynecol, 371 Rue Doyen Gaston Giraud, F-34295 Montpellier 5, France.
EM pl-giacalone@chu-montpellier.fr
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P, 1998, BRIT J PLAST SURG, V51, P79, DOI 10.1016/S0007-1226(98)80142-2
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
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   Joseph E, 2000, WOUNDS, V12, P60
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NR 12
TC 5
Z9 5
U1 0
U2 1
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1075-122X
J9 BREAST J
JI Breast J.
PD SEP-OCT
PY 2006
VL 12
IS 5
BP 481
EP 484
DI 10.1111/j.1075-122X.2006.00306.x
PG 4
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA 079TO
UT WOS:000240201000015
PM 16958970
DA 2026-07-24
ER
PT J
AU Labler, L
   Keel, M
   Trentz, O
   Heinzelmann, M
AF Labler, Ludwig
   Keel, Marius
   Trentz, Otmar
   Heinzelmann, Michael
TI Wound conditioning by vacuum assisted closure (VAC) in postoperative
   infections after dorsal spine surgery
SO EUROPEAN SPINE JOURNAL
LA English
DT Article
DE spine; instrumentation; infection; vacuum assisted closure; topic
   negative pressure
ID PARASPINOUS MUSCLE FLAPS; SOFT-TISSUE DEFECTS; COMPLEX BACK WOUNDS;
   SUBATMOSPHERIC PRESSURE; RETROSPECTIVE ANALYSIS; IDIOPATHIC SCOLIOSIS;
   DELAYED INFECTIONS; RISK-FACTORS; CORD-INJURY; INSTRUMENTATION
AB The use of vacuum assisted closure (V.A.C.) therapy in postoperative infections after dorsal spinal surgery was studied retrospectively. Successful treatment was defined as a stable healed wound that showed no signs of acute or chronic infection. The treatment of the infected back wounds consisted of repeated debridement, irrigation and open wound treatment with temporary closure by V.A.C. The instrumentation was exchanged or removed if necessary. Fifteen patients with deep subfascial infections after posterior spinal surgery were treated. The implants were exchanged in seven cases, removed completely in five cases and left without changing in one case. In two cases spinal surgery consisted of laminectomy without instrumentation. In two cases only the wound defects were closed by muscle flap, the remaining ones were closed by delayed suturing. Antibiotic treatment was necessary in all cases. Follow up was possible in 14 patients. One patient showed a new infection after treatment. The study illustrates the usefulness of V.A.C. therapy as a new alternative management for wound conditioning of complex back wounds after deep subfascial infection.
C1 Univ Spital Zurich, Unfallchirurg Klin, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Labler, L (通讯作者)，Univ Spital Zurich, Unfallchirurg Klin, Zurich, Switzerland.
EM ludwig.labler@usz.ch
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NR 70
TC 57
Z9 75
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013 USA
SN 0940-6719
J9 EUR SPINE J
JI Eur. Spine J.
PD SEP
PY 2006
VL 15
IS 9
BP 1388
EP 1396
DI 10.1007/s00586-006-0164-2
PG 9
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 082BW
UT WOS:000240362500013
PM 16835734
OA Green Submitted, Green Accepted
DA 2026-07-24
ER
PT J
AU Maegele, M
   Gregor, S
   Yuecel, N
   Simanski, C
   Paffrath, T
   Rixen, D
   Heiss, MM
   Rudroff, C
   Saad, S
   Perbix, W
   Wappler, F
   Harzheim, A
   Schwarz, R
   Bouillon, B
AF Maegele, Marc
   Gregor, Sven
   Yuecel, Nedim
   Simanski, Christian
   Paffrath, Thomas
   Rixen, Dieter
   Heiss, Markus M.
   Rudroff, Claudia
   Saad, Stefan
   Perbix, Walter
   Wappler, Frank
   Harzheim, Andreas
   Schwarz, Rosemarie
   Bouillon, Bertil
TI One year ago not business as usual: Wound management, infection and
   psychoemotional control during tertiary medical care following the 2004
   Tsunami disaster in southeast Asia
SO CRITICAL CARE
LA English
DT Article
ID VACUUM-SEALING TECHNIQUE; AEROMONAS-HYDROPHILA; SOFT-TISSUE; CUTANEOUS
   MELIOIDOSIS; ASSISTED CLOSURE; SURVIVORS; PNEUMONIA; THAILAND;
   PSEUDOMALLEI; TRIAL
AB Introduction Following the 2004 tsunami disaster in southeast Asia severely injured tourists were repatriated via airlift to Germany. One cohort was triaged to the Cologne-Merheim Medical Center ( Germany) for further medical care. We report on the tertiary medical care provided to this cohort of patients.
   Methods This study is an observational report on complex wound management, infection and psychoemotional control associated with the 2004 Tsunami disaster. The setting was an adult intensive care unit (ICU) of a level I trauma center and subjects included severely injured tsunami victims repatriated from the disaster area ( 19 to 68 years old; 10 females and 7 males with unknown co-morbidities).
   Results Multiple large flap lacerations ( 2 x 3 to 60 x 60 cm) at various body sites were characteristic. Lower extremities were mostly affected (88%), followed by upper extremities (29%), and head (18%). Two-thirds of patients presented with combined injuries to the thorax or fractures. Near-drowning involved the aspiration of immersion fluids, marine and soil debris into the respiratory tract and all patients displayed signs of pneumonitis and pneumonia upon arrival. Three patients presented with severe sinusitis. Microbiology identified a variety of common but also uncommon isolates that were often multiresistant. Wound management included aggressive debridement together with vacuum-assisted closure in the interim between initial wound surgery and secondary closure. All patients received empiric anti-infective therapy using quinolones and clindamycin, later adapted to incoming results from microbiology and resistance patterns. This approach was effective in all but one patient who died due to severe fungal sepsis. All patients displayed severe signs of post-traumatic stress response.
   Conclusion Individuals evacuated to our facility sustained traumatic injuries to head, chest, and limbs that were often contaminated with highly resistant bacteria. Transferred patients from disaster areas should be isolated until their microbial flora is identified as they may introduce new pathogens into an ICU. Successful wound management, including aggressive debridement combined with vacuum-assisted closure was effective. Initial anti-infective therapy using quinolones combined with clindamycin was a good first-line choice. Psychoemotional intervention alleviated severe post-traumatic stress response. For optimum treatment and care a multidisciplinary approach is mandatory.
C1 Univ Witten Herdecke, CMMC, Dept Traumatol & Orthoped Surg, Intens Care Unit, D-51109 Cologne, Germany.
   Univ Witten Herdecke, CMMC, Dept Visceral Surg, D-51109 Cologne, Germany.
   Univ Witten Herdecke, CMMC, Dept Plast & Reconstruct Surg, D-51109 Cologne, Germany.
   Univ Witten Herdecke, CMMC, Dept Anaesthesiol, D-51109 Cologne, Germany.
   Univ Witten Herdecke, CMMC, Dept Radiol, D-51109 Cologne, Germany.
   Univ Witten Herdecke, CMMC, Dept Microbiol, D-51109 Cologne, Germany.
C3 Witten Herdecke University; University of Cologne; Witten Herdecke
   University; University of Cologne; Witten Herdecke University;
   University of Cologne; University of Cologne; Witten Herdecke
   University; University of Cologne; Witten Herdecke University;
   University of Cologne; Witten Herdecke University
RP Maegele, M (通讯作者)，Univ Witten Herdecke, CMMC, Dept Traumatol & Orthoped Surg, Intens Care Unit, Ostmerheimerstr, D-51109 Cologne, Germany.
EM Marc.Maegele@t-online.de
RI Rudroff, Claudia Lieselotte/KSM-9547-2024
OI Rudroff, Claudia Lieselotte/0000-0003-3347-0108
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NR 48
TC 37
Z9 37
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1466-609X
EI 1364-8535
J9 CRIT CARE
JI Crit. Care
PY 2006
VL 10
IS 2
AR R50
DI 10.1186/cc4868
PG 9
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 083DP
UT WOS:000240436400011
PM 16584527
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Nagell, CF
   Holte, K
AF Nagell, Carl Frederik
   Holte, Kathrine
TI Treatment of anastomotic leakage after rectal resection with transrectal
   vacuum-assisted drainage (VAC) - A method for rapid control of pelvic
   sepsis and healing
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE anastomotic leakage; VAC; rectal; healing
ID CLOSURE SYSTEM; WOUND CONTROL; RISK-FACTORS
AB Objectives : Anastomotic leakage after rectal resection is associated with high morbidity and mortality. Patients without peritonitis can be treated conservatively by transrectal rinsing and drainage. However, healing is often very slow, and formation of abundant scar tissue resulting in a poor functional result is not uncommon. Vacuum-assisted closure (VAC) has been shown to accelerate wound healing by increasing local blood flow, reducing bacterial load and stimulating growth of granulation tissue. In this paper, we describe VAC as a method for treating anastomotic leakage after rectal resection. Methods : Four patients with anastomotic leakage after rectal resections were treated with VAC. Results : Healing time for these patients was median 51 days (43-195). The control group consisted of patients treated conservatively in the previous 5-year period. Ten patients were identified with median healing time 336 days (52-1434).
   Conclusions :VAC treatment may possibly shorten healing time of anastomotic leakages after rectal resection. However, the presented results are preliminary, with only few patients included, and obviously, larger, randomized, clinical trials are needed to confirm these results and establish the indication for VAC treatment in clinical practice. We believe VAC therapy is a promising treatment of anastomotic leakage after rectal resection.
C1 Hvidovre Univ Hosp, Dept Surg Gastroenterol, DK-2650 Hvidovre, Copenhagen, Denmark.
C3 University of Copenhagen
RP Nagell, CF (通讯作者)，Hvidovre Univ Hosp, Dept Surg Gastroenterol, Kettegaards Alle, DK-2650 Hvidovre, Copenhagen, Denmark.
EM rikke.frederik@dadlnet.dk
RI Holte, Kathrine/MCX-4615-2025
OI Holte, Kathrine/0009-0004-4680-8344
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NR 11
TC 55
Z9 61
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD OCT
PY 2006
VL 21
IS 7
BP 657
EP 660
DI 10.1007/s00384-005-0083-4
PG 4
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 087FV
UT WOS:000240729200007
PM 16447032
DA 2026-07-24
ER
PT J
AU Andrews, BT
   Smith, RB
   Chang, KE
   Scharpf, J
   Goldstein, DP
   Funk, GF
AF Andrews, Brian T.
   Smith, Russell B.
   Chang, Kristi E.
   Scharpf, Joseph
   Goldstein, David P.
   Funk, Gerry F.
TI Management of the radial forearm free flap donor site with the
   vacuum-assisted closure (VAC) system
SO LARYNGOSCOPE
LA English
DT Article
DE vacuum-assisted closure; VAC; topical negative pressure dressing;
   bolster dressing; radial forearm free flap donor site; split-thickness
   skin graft
ID SECURING SKIN-GRAFTS; WOUND CONTROL; MORBIDITY; COMPLICATIONS; COVERAGE
AB Introduction: The radial forearm free flap is a popular reconstructive flap in modern head and neck surgery. Poor wound healing at the forearm donor site is common and frequently results in tendon exposure. The Vacuum-Assisted Closure (VAC) system (Kinetic Concepts Inc., San Antonio, TX) is a topical negative pressure dressing that has been shown to improve skin graft viability when used as a bolster dressing. In this study, we investigated the use of the VAC system in the management of the radial forearm free flap donor site. Methods. A retrospective chart review was performed on all subjects who underwent a radial forearm free flap reconstruction in which the VAC system was used as a bolster dressing at the donor site from January 1, 2003, through March 31, 2005. Results: Thirty-four consecutive subjects were included in the study. Exposed tendon did not occur in 14 (0%) subjects in which the VAC bolster was used for a minimum of 6 days. Eleven of the 20 subjects (55%) who used the VAC bolster for 5 days demonstrated small amounts of tendon exposure (<2 cm) on follow-up clinic examination. The minimum follow up for all subjects was 4 months. Conclusion: This study demonstrates that the VAC system is a feasible alternative to conventional bolster dressing in the management of the radial forearm free flap skin-grafted donor site. Based on this study, when used for a minimum of 6 days, the VAC bolster dressing eliminated tendon exposure at the forearm donor site.
C1 Univ Iowa, Coll Med, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
C3 University of Iowa
RP Funk, GF (通讯作者)，Univ Iowa, Coll Med, Dept Otolaryngol Head & Neck Surg, 21272 Pomerantz Pavill,200 Hawkins Dr, Iowa City, IA 52242 USA.
EM gerry-funk@uiowa.edu
RI goldstein, David/AAT-6302-2020
OI Andrews, Brian/0000-0003-3994-6808; Chang, Kristi/0000-0002-8083-7497
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   Richardson D, 1997, PLAST RECONSTR SURG, V99, P109, DOI 10.1097/00006534-199701000-00017
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NR 20
TC 45
Z9 48
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0023-852X
J9 LARYNGOSCOPE
JI Laryngoscope
PD OCT
PY 2006
VL 116
IS 10
BP 1918
EP 1922
DI 10.1097/01.mlg.0000235935.07261.98
PG 5
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA 090ER
UT WOS:000240933900037
PM 17003705
DA 2026-07-24
ER
PT J
AU Gabriel, A
   Heinrich, C
   Shores, JT
   Baqai, WK
   Rogers, FR
   Gupta, S
AF Gabriel, Allen
   Heinrich, Cherrie
   Shores, Jaimie T.
   Baqai, Waheed K.
   Rogers, Frank R.
   Gupta, Subhas
TI Reducing bacterial bioburden in infected wounds with vacuum assisted
   closure and a new silver dressing - A pilot study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE; ANTIMICROBIAL ACTIVITY; EFFICACY;
   THERAPY; SAFETY
AB The use of silver is increasing rapidly in the management of infected wounds and wounds at risk for infection. This 5-patient case series reviews the results of a pilot study designed to determine efficacy and safety of negative pressure wound therapy (NPWT; V.A.C.(R) Therapy(TM), KCl, San Antonio, Tex) with the new silver foam dressing (V.A.C.(R) GranuFoam(R) Silver(TM) Dressing, KCl). Data on wound progression and the primary endpoints-time to clear infection, time to wound closure, and time to discharge from hospital-are detailed in this manuscript. For the 5 patients treated with NPWT and the silver foam dressing, the mean time for treatment was 13.00 +/- 3.39 days and the mean time to patient discharge was 16.00 +/- 6.63 days. Wounds were clear of clinical signs of infection in 7.00 +/- 1.58 days and closed in 19.20 +/- 8.76 days.
C1 Loma Linda Univ, Dept Surg, Div Plast & Reconstruct Surg, Loma Linda, CA 92354 USA.
   Loma Linda Univ, Ctr Hlth Res, Loma Linda, CA 92354 USA.
C3 Loma Linda University; Loma Linda University
RP Gupta, S (通讯作者)，Loma Linda Univ, Dept Surg, Div Plast & Reconstruct Surg, 11175 Campus Dr,Coleman Pavil 21126, Loma Linda, CA 92354 USA.
EM sgupta@ahs.llumc.edu
RI Gupta, Subhas/C-5458-2018; Gabriel, Allen/AFK-3548-2022
OI Gupta, Subhas/0000-0001-5091-3922; 
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   Weinfeld AB, 2005, ANN PLAS SURG, V54, P178, DOI 10.1097/01.sap.0000143606.39693.3f
   White R.J., 2001, BR J NURS, V10, P16079, DOI DOI 10.12968/BJON.2001.10.SUP4.16079
   Wright JB, 2002, WOUND REPAIR REGEN, V10, P141, DOI 10.1046/j.1524-475X.2002.10308.x
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NR 39
TC 22
Z9 28
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2006
VL 18
IS 9
BP 245
EP 255
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 091QB
UT WOS:000241042300001
DA 2026-07-24
ER
PT J
AU de Vaumas, C
   Bronchard, R
   Montravers, P
AF de Vaumas, C.
   Bronchard, R.
   Montravers, P.
TI Non pharmacological treatment of severe cutaneous infections: hyperbaric
   oxygen therapy, dressings and local treatments
SO ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION
LA French
DT Article
DE necrotising cellulitis; necrotising fasciitis; hyperbaric oxygen
   therapy; gauze dressing; vacuum-assisted closure therapy
ID VACUUM-ASSISTED CLOSURE; CONVENTIONAL TREATMENT; NECROTIZING FASCIITIS;
   WOUND CONTROL; CELLULITIS; MANAGEMENT; EFFICACY; DEFECTS
AB Beside conventional therapy, the management of necrotizing cellulitis and fasciitis is based on non-pharmacological treatments. Hyperbaric oxygen therapy and dressings are the most frequently used techniques. The usefulness of hyperbaric oxygen therapy is clearly demonstrated in experimental studies while the efficacy of this technique is poorly assessed in clinical practice. The French consensus conference has concluded to an adjuvant role of hyperbaric oxygen therapy combined to intensive care management, surgery and antibiotic therapy. Occlusive conventional dressings using humidor vaseline gauze dressings are largely used. Calcium alginate or silver coated dressings might be useful. In addition, vacuum-assisted closure therapy could be proposed in replacement of conventional dressings. (c) 2006 Elsevier SAS. Tous droits reserves.
C1 Univ Paris 07, Assistance Publ Hop Paris, CHU Bichat Claude Bernard Paris, Dept Anesthesie Reanimat Chirurg, F-75018 Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Bichat-Claude Bernard - APHP; Hopital
   Universitaire Saint-Louis - APHP
RP de Vaumas, C (通讯作者)，Univ Paris 07, Assistance Publ Hop Paris, CHU Bichat Claude Bernard Paris, Dept Anesthesie Reanimat Chirurg, 46 Rue Henir Huchard, F-75018 Paris, France.
EM cyrille.de-vaumas@bch.aphp.fr
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bonnamy C, 2000, ANN CHIR, V125, P982, DOI 10.1016/S0003-3944(00)00411-9
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   Sposato G, 2001, BRIT J PLAST SURG, V54, P235, DOI 10.1054/bjps.2000.3537
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   Vermeulen H, 2005, BJS-BRIT J SURG, V92, P665, DOI 10.1002/bjs.5055
   2001, ANN DERMATOL VENER 2, V128, P458
NR 24
TC 4
Z9 6
U1 0
U2 3
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0750-7658
EI 1769-6623
J9 ANN FR ANESTH
JI Ann. Fr. Anest. Reanim.
PD SEP
PY 2006
VL 25
IS 9
BP 986
EP 989
DI 10.1016/j.annfar.2006.03.022
PG 4
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA 092IY
UT WOS:000241091400013
PM 16675193
DA 2026-07-24
ER
PT J
AU Draus, JM
   Huss, SA
   Harty, NJ
   Cheadle, WG
   Larson, GM
AF Draus, John M., Jr.
   Huss, Sara A.
   Harty, Niall J.
   Cheadle, William G.
   Larson, Gerald M.
TI Enterocutaneous fistula: Are treatments improving?
SO SURGERY
LA English
DT Article; Proceedings Paper
CT 63rd Annual Meeting of the Central-Surgical-Association
CY MAR 09-11, 2006
CL Louisville, KY
SP Cent Surg Assoc
ID ENDOSCOPIC TREATMENT; EXTERNAL FISTULAS; MANAGEMENT; EXPERIENCE; CLOSURE
AB Background. We studied the etiology, treatment, and outcome of enterocutaneous fistulas in 106 patients to evaluate our current practice and the impact of newer therapies'-octreotide, wound vacuum-assisted closure (VAC), and fibrin glue-on clinical outcomes. Review of the literature and our own 1990 study indicate a mortality rate of 5 % to 20 % for enterocutaneous fistula, and a healing rate of 75 % to 85 % after definitive surgery.
   Methods. We reviewed all cases of gastrointestinal-cutaneous fistula from 1997 to 2005 at 2 large teaching hospitals. We identified 106 patients with enterocutaneous fistula; patients with irritable bowel disease and anorectal fistulas were excluded.
   Results. The origin of the fistula was the small bowel in 67 patients, colon in 26, stomach in 8, and duodenum in 5. The etiology of the fistula was previous operation in 81 patients, trauma in 15, hernia mesh erosion in 6, diverticulitis in 2, and radiation in 2. Of the 106 patients in the study, 31 had a high output fistula (greater than 200 mL/day), 44 had a low output fistula, and, in 31 patients, the fistula output was low but there was no record of volume Initial treatment was nonoperative except for patients with an abscess who needed urgent drainage. In 24 patients, the effect of octreotide was monitored. in 8 patients, fistula output declined; in 16 patients, octreotide was of no benefit. Fibrin glue was used in 8 patients and was of benefit to 1. The wound VAC was used in 13 patients: 12 patients still required operative repair of the fistula, whereas the fistula was healed in] patient. The main benefit of the VAC system was improved wound care in all patients before definitive surgery. Total parenteral nutrition was used in most patients to provide nutritional support. Operative repair was performed in 77 patients and was successful in 69 (89 %), failing in 6 patients with persistent cancer or infection. Nonoperative treatment was wed in 29 patients and resulted in healing in 60 %. Of 106 patients, 7 (7 %) died of fistula complications. The cause of death was persistence or recurrence of cancer in 4 patients and persistent sepsis in 3.
   Conclusion. Enterocutaneous fistula continues to be a serious surgical problem. The wound VAC and fibrin glue had anecdotal successes (n = 2), and one-third of patients responded to octreotide. We believe that octreotide should be tried in most patients and that the wound VAC has a role in selected patients. Although 7 % overall mortality is lower than in previous studies, the number managed without operation (27 %) remains the same. In addition to early control of sepsis, nutritional support, and wound care, a well-timed operation was the most effective treatment.
C1 Univ Louisville, Hlth Sci Ctr, Sch Med, Dept Surg, Louisville, KY 40202 USA.
C3 University of Louisville
RP Larson, GM (通讯作者)，Univ Louisville, Hlth Sci Ctr, Sch Med, Dept Surg, 550 S Jackson St,2nd Fl ACB, Louisville, KY 40202 USA.
EM gmlars01@louisville.edu
RI ; Draus, John/JAO-5255-2023
OI aus, John/0009-0008-4932-5478; 
CR APOSTOLOS K, 1996, SURG CLIN NA, V76, P1175
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NR 17
TC 140
Z9 159
U1 0
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD OCT
PY 2006
VL 140
IS 4
BP 570
EP 576
DI 10.1016/j.surg.2006.07.003
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 093GD
UT WOS:000241155200020
PM 17011904
DA 2026-07-24
ER
PT J
AU Wong, LK
   Nesbit, RD
   Turner, LA
   Sargent, LA
AF Wong, Lesley K.
   Nesbit, Robert D.
   Turner, Leslie A.
   Sargent, Larry A.
TI Management of a circumferential lower extremity degloving injury with
   the use of vacuum-assisted closure
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Article
DE vacuum-assisted closure therapy; degloving injury; split thickness skin
   graft
ID WOUND CONTROL
AB A 58-year-old male presented with a large circumferential degloving injury and was immediately taken to the operating room for further assessment of his wound. At that time, a plastic surgeon was consulted to manage the wound due to its size and significant soft tissue loss. The decision was made to manage the patient's wound with the vacuum-assisted closure (VAC) device to prepare the wound bed for grafting. After three weeks of VAC therapy, the wound bed was revascularized with granulation tissue and was ready for grafting. The patient underwent a successful split thickness skin graft on hospital Day 23 and was discharged home. Follow-up visits revealed no scar contracture or functional limitations.
C1 Univ Tennessee, Coll Med, Chattanooga Unit, Dept Plast & Reconstruct Surg,Hayes Hand Ctr, Chattanooga, TN 37403 USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center
RP Wong, LK (通讯作者)，Univ Tennessee, Coll Med, Chattanooga Unit, Dept Plast & Reconstruct Surg,Hayes Hand Ctr, 979 E 3rd St,Erlanger Med Mall,Suite C 920, Chattanooga, TN 37403 USA.
EM utplastics@thepsg.org
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   DeFranzo AJ, 1999, PLAST RECONSTR SURG, V104, P2145, DOI 10.1097/00006534-199912000-00031
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   MCGROUTHER DA, 1980, BRIT J PLAST SURG, V33, P9, DOI 10.1016/0007-1226(80)90046-6
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
NR 8
TC 20
Z9 30
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0038-4348
EI 1541-8243
J9 SOUTH MED J
JI South.Med.J.
PD JUN
PY 2006
VL 99
IS 6
BP 628
EP 630
DI 10.1097/01.smj.0000217111.35160.09
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 095NW
UT WOS:000241315600016
PM 16800422
DA 2026-07-24
ER
PT J
AU Andrews, BT
   Smith, RB
   Goldstein, DP
   Funk, GF
AF Andrews, Brian T.
   Smith, Russell B.
   Goldstein, David P.
   Funk, Gerry F.
TI Management of complicated head and neck wounds with vacuum-assisted
   closure system
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Article
DE vacuum-assisted closures; VAC; negative pressure dressing; head and neck
   wounds; scalping injuries; split-thickness skin grafts
ID SECURING SKIN-GRAFTS; PRESSURE
AB Background. The vacuum-assisted closure system (VA.C.), or negative pressure dressings, has been successfully used to manage complex wounds of the torso and extremities, but its role in the head and neck region has not been frequently described.
   Methods. A retrospective study was performed. The V.A.C. system (Kinetic Concepts Inc., San Antonio, TX) was used at the University of Iowa Hospitals and Clinics for management of complicated head and neck wounds.
   Results. The V.A.C. system was utilized at 13 sites for 12 patients. Nine subjects had exposed calvarium (4 had failed pedided reconstructive flaps, 3 had ablative or Moh's defects, and 2 had traumatic scalping injuries) necessitating bony coverage. Three subjects had the V.A.C. system used as a bolster dressing placed over split-thickness skin grafts (STSGs) used to reconstruct large defects of the face and skull, and 1 patient had a large soft tissue neck defect after radical surgical resection for necrotizing fascitis. One subject used the V.A.C. system for the management of 2 distinct wounds. All patients had successful healing of their wounds with the V.A.C. system without complication. All STSGs had 100% viability after 5 to 7 days of the VA.C. system use as a bolster dressing.
   Conclusion. This study demonstrates the V.A.C. system is a valuable tool in the management of complicated head and neck wounds. (c) 2006 Wiley Periodicals, Inc.
C1 Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
C3 University of Iowa
RP Andrews, BT (通讯作者)，Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 21200 Pomerantz Pavill,200 Hawkins Dr, Iowa City, IA 52242 USA.
EM brian-andrews@uiowa.edu
RI goldstein, David/AAT-6302-2020
OI Andrews, Brian/0000-0003-3994-6808
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Fabian TS, 2000, AM SURGEON, V66, P1136
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
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   Molnar JA, 2000, PLAST RECONSTR SURG, V105, P174, DOI 10.1097/00006534-200001000-00030
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
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NR 11
TC 56
Z9 61
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD NOV
PY 2006
VL 28
IS 11
BP 974
EP 981
DI 10.1002/hed.20496
PG 8
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA 097PL
UT WOS:000241460300002
PM 16983694
DA 2026-07-24
ER
PT J
AU Vuerstaek, JDD
   Vainas, T
   Wuite, J
   Nelemans, P
   Neumann, MHA
   Veraart, JCJM
AF Vuerstaek, Jeroen D. D.
   Vainas, Tryfon
   Wuite, Jan
   Nelemans, Patty
   Neumann, Martino H. A.
   Veraart, Joep C. J. M.
TI State-of the-art treatment of chronic leg ulcers: a randomized
   controlled trial comparing vacuum-assisted closure (VAC) with modern
   wound dressings
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID BED PREPARATION; VENOUS ULCERS
AB Background: Current treatment modalities for chronic leg ulcers are time consuming, expensive, and only moderately successful. Recent data suggest that creating a subatmospheric pressure by vacuum-assisted closure (V.A.C., KCI Concepts, San Antonio, Texas) therapy supports the wound healing process.
   Methods: The efficacy of vacuum-assisted closure in the treatment of chronic leg ulcers was prospectively studied in a randomized controlled trial in which 60 hospitalized patients with chronic leg ulcers were randomly assigned to either treatment by V.A.C. or therapy with conventional wound care techniques. The primary outcome measure was the time to complete healing (days). Statistical analysis was performed on the intention-to-treat basis.
   Results. The median time to complete healing was 29 days (95% confidence interval [CI], 25.5 to 32.5) in the V.A.C. group compared with 45 days (95% CI, 36.2 to 53.8) in the control group (P=.0001). Further, wound bed preparation during V.A.C. therapy was also significantly shorter at 7 days (95% C1 5.7 to 8.3) than during conventional wound care at 17 days (95% CI, 10 to 24, P=.005). The costs of conventional wound care were higher than those of V.A.C. Both groups showed a significant increase in quality of life at the end of therapy and a significant decrease in pain scores at the end of follow-up.
   Conclusions: V.A.C. therapy should be considered as the treatment of choice for chronic leg ulcers owing to its significant advantages in the time to complete healing and wound bed preparation time compared with conventional wound care. Particularly during the preparation stage, V.A.C. therapy appears to be superior to conventional wound care techniques.
C1 DermaClin, B-3600 Ghent, Belgium.
   Univ Hosp Maastricht, Dept Dermatol, Maastricht, Netherlands.
   Univ Hosp Maastricht, Dept Surg, Maastricht, Netherlands.
   Atrium Med Ctr, Dept Dermatol, Heerlen, Netherlands.
   Univ Maastricht, Dept Epidemiol, Maastricht, Netherlands.
   Erasmus MC, Dept Dermatol, Rotterdam, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Atrium Medical Center; Maastricht University; Erasmus University
   Rotterdam; Erasmus MC
RP Vuerstaek, JDD (通讯作者)，DermaClin, Collegelaan 10, B-3600 Ghent, Belgium.
EM info@DermaClinic.be
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NR 37
TC 269
Z9 321
U1 0
U2 20
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD NOV
PY 2006
VL 44
IS 5
BP 1029
EP 1037
DI 10.1016/j.jvs.2006.07.030
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 101BQ
UT WOS:000241714300029
PM 17000077
OA Bronze
DA 2026-07-24
ER
PT J
AU Schuster, R
   Singh, J
   Safadi, BY
   Wren, SM
AF Schuster, Rob
   Singh, Jaskanwal
   Safadi, Bassem Y.
   Wren, Sherry M.
TI The use of acellular dermal matrix for contaminated abdominal wall
   defects: wound status predicts success
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT 30th Annual Surgical Symposium of the Association-of-VA-Surgeons
CY MAY 07-09, 2006
CL Cincinnati, OH
SP Assoc VA Surg
DE contaminated; hernia; AlloDerm; acellular dermal matrix; wound
ID INCISIONAL HERNIA; VENTRAL HERNIAS; REPAIR; ALLODERM; MESH;
   RECONSTRUCTION; EXPERIENCE; MANAGEMENT; SURGERY
AB Background: Contaminated abdominal wall fascial defects present a challenging problem. The use of human acellular dermal matrix (AlloDerm; LifeCell Corp., Branchburg, NJ) provides a novel method of primary closure of abdominal wall defects in this setting. The aim of the current study was to determine what factors predicted fascial wall failure as determined by the presence of hernia on follow-up exam after AlloDerm placement.
   Methods: All patients who underwent surgery for contaminated abdominal wall fascial defects with placement of AlloDerm from June 2003 to September 2005 at a tertiary care Veterans Affairs hospital were included in the analysis. Patients were followed until hernia recurrence or last clinic visit.
   Results: Eighteen patients had AlloDerm placed for contaminated fascial defects and all were included in the analysis. Primary wound closure was performed on 12/18 (67%) patients, with 6/18 (33%) patients initially left with open wounds. Patients with open wounds were treated with wound vacuum-assisted closure (VAC) devices (4/6) or saline dressings (2/6). Overall ventral hernia recurrence rate was 50% (9/18) with an average follow up of 9.1 months. Patients who had primary wound closure at the completion of the operation had a 33% (4/12) recurrence rate. Patients who did not have primary wound closure had an 83.3% (5/6) recurrence rate. The significant difference shows (P = .03) that open wound status predicts recurrence. The average size of AlloDerm sheets used was 164.0 cm(2) in the closed group and 146.2 cm(2) in the primary open wound group (P = .64). Average cost per patient was $4680 for AlloDerm.
   Conclusion: These data suggest that an open wound in the postoperative period after AlloDerm placement for treatment of contaminated fascial defects is associated with a high probability of hernia recurrence. Our data do not support the use of this expensive material unless there is a good chance of having a closed wound. (c) 2006 Excerpta Medica Inc. All rights reserved.
C1 Arizona Special Phys, Dept Surg, Gilbert, AZ 85234 USA.
   Palo Alto Vet Hlth Care Syst, Dept Surg, Palo Alto, CA USA.
   Stanford Univ, Dept Surg, Stanford, CA 94305 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Palo Alto Health Care System; Stanford University
RP Schuster, R (通讯作者)，Arizona Special Phys, Dept Surg, 3921 E Baseline,Suite 200, Gilbert, AZ 85234 USA.
EM robschuster@hotmail.com
RI ; Wren, Sherry/NIS-6346-2025
OI Safadi, Bassem/0000-0002-4473-7202; Wren, Sherry/0000-0002-5723-8226
CR [Anonymous], 1997, HERNIA, DOI DOI 10.1007/BF01234750
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   BROWN GL, 1985, ANN SURG, V201, P705, DOI 10.1097/00000658-198506000-00006
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   Choe JM, 2001, UROLOGY, V58, P482, DOI 10.1016/S0090-4295(01)01205-5
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NR 20
TC 81
Z9 85
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD NOV
PY 2006
VL 192
IS 5
BP 594
EP 597
DI 10.1016/j.amjsurg.2006.08.017
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 102NW
UT WOS:000241820000007
PM 17071190
DA 2026-07-24
ER
PT J
AU Jungius, KP
   Chilla, BK
   Labler, L
   Teodorovic, N
   Marincek, B
AF Jungius, K. P.
   Chilla, B. K.
   Labler, L.
   Teodorovic, N.
   Marincek, B.
TI Non-invasive assessment of the perfusion of wounds using Power Doppler
   imaging:: Vacuum assisted Closure® versus direct wound closure
SO ULTRASCHALL IN DER MEDIZIN
LA German
DT Article
DE Power Doppler; vacuum-sealing; vacuum assisted closure; perfusion
ID MANAGEMENT; PHYSIOLOGY; ULTRASOUND; THERAPY
AB Aim: The goal of our study was to assess the perfusion in wounds treated by Vacuum assisted closure (VAC) compared to primary wound closure (R)
   Method: Power Doppler Ultrasound (PDUS) was carried out under standardised conditions in 15 VAC-treated and 10 primarily closed wounds as well as on altogether 25 intraindividual reference areas. All data were sent to a work station for post-processing to determine the perfused area. Statistical data analysis was performed with the Mann-Whitney test.
   Results: Both VAC((c))-treated wounds and primarily closed wounds showed a significant increase of the perfusion when compared to the intraindividual reference area (p < 0.0001). In VAC-treated wounds, a markedly increased perfusion was measured compared to the wounds closed primarily (p < 0.0001). Perfusion decreased during treatment, but in two VAC-treated wounds, an initial increase of the perfusion was observed. Both these wounds were grossly infected.
   Conclusion: PDUS allows the quantification of the differences in wound perfusion. This can be helpful in the detection of progressive local wound infections.
C1 Inst Diagnost Radiol, Zurich, Switzerland.
   Klin Widerherstellungschirurg, Zurich, Switzerland.
RP Jungius, KP (通讯作者)，Spitalzentrum Oberwallis, Dept Radiol, Uberlandstr 14, CH-3900 Brig, Switzerland.
EM karl.peter.jungius@rsv-gnw.ch
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Fleischmann W, 1996, UNFALLCHIRURG, V99, P283
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
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   Moskalik AP, 2001, J ULTRAS MED, V20, P713, DOI 10.7863/jum.2001.20.7.713
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NR 18
TC 2
Z9 2
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0172-4614
EI 1438-8782
J9 ULTRASCHALL MED
JI Ultraschall Med.
PD OCT
PY 2006
VL 27
IS 5
BP 473
EP 477
DI 10.1055/s-2005-859001
PG 5
WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
GA 103XI
UT WOS:000241920100011
PM 16596505
DA 2026-07-24
ER
PT J
AU Leininger, BE
   Rasmussen, TE
   Smith, DL
   Jenkins, DH
   Coppola, C
AF Leininger, Brian E.
   Rasmussen, Todd E.
   Smith, David L.
   Jenkins, Donald H.
   Coppola, Christopher
TI Experience with wound VAC and delayed primary closure of contaminated
   soft tissue injuries in Iraq
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article; Proceedings Paper
CT 19th Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma
CY JAN 10-14, 2006
CL Orlando, FL
SP Eastern Assoc Surg Trauma
DE wound VAC; delayed primary closure; high-energy soft tissue injury;
   Iraq; war wounds; contaminated; contaminated wounds; wound management;
   military trauma
ID ASSISTED CLOSURE; THERAPY
AB Backgound: Wartime missile injuries are frequently high-energy wounds that devitalize and contaminate tissue, with high risk for infection and wound complications. Debridement, irrigation, and closure by secondary intention are fundamental principles for the management of these injuries. However, closure by secondary intention was impractical in Iraqi patients. Therefore, wounds were closed definitively before discharge in all Iraqi patients treated for such injures at our hospital. A novel wound management protocol was developed to facilitate this practice, and patient outcomes were tracked. This article describes that protocol and discusses the outcomes in a series of 88 wounds managed with it.
   Methods. High-energy injuries were treated with rapid aggressive debridement and pulsatile lavage, then covered with negative pressure (vacuum-assisted closure [VAC]) dressings. Patients underwent serial operative irrigation and debridement until wounds appeared clean to gross inspection, at which time they were closed primarily. Patient treatment and outcome data were recorded in a prospectively updated database.
   Results. Treatment and outcomes data from September 2004 through May 2005 were analyzed retrospectively. There were 88 high-energy soft tissue wounds identified in 77 patients. Surprisingly, for this cohort of patients the wound infection rate was 0% and the overall wound complication rate was 0%.
   Conclusion: This series of 88 cases is the first report of the use of a negative pressure dressing (wound VAC) as part of the definitive management of high-energy soft tissue wounds in a deployed wartime environment. Our experience with these patients suggests that conventional wound management doctrine may be improved with the wound VAC, resulting in earlier more reliable primary closure of wartime injuries.
C1 Wilford Hall USAF Med Ctr, Dept Surg, Lackland AFB, TX 78236 USA.
C3 United States Department of Defense; United States Air Force
RP Leininger, BE (通讯作者)，Wilford Hall USAF Med Ctr, Dept Surg, 2200 Bergquist Dr,Suite 1, Lackland AFB, TX 78236 USA.
EM brian.leininger@lackland.af.mil
RI Rasmussen, Todd/Y-2122-2019
OI Rasmussen, Todd/0000-0003-1120-4116; Coppola,
   Christopher/0000-0002-2683-4324
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   *BORD I WALT REED, 2004, EM WAR SURG
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   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
NR 10
TC 157
Z9 189
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD NOV
PY 2006
VL 61
IS 5
BP 1207
EP 1211
DI 10.1097/01.ta.0000241150.15342.da
PG 5
WC Critical Care Medicine; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 105TB
UT WOS:000242054100030
PM 17099530
DA 2026-07-24
ER
PT J
AU Trop, M
   Schintler, M
   Urban, E
   Roedl, S
   Stockenhuber, A
AF Trop, Marija
   Schintler, Michael
   Urban, Eva
   Roedl, Siegfried
   Stockenhuber, Andrea
TI Are 1:4 mesh and donor site contraindications for vacuum-assisted
   closure device?
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
ID TOPICAL NEGATIVE-PRESSURE; THERAPY; ARTERY
C1 Med Unv Graz, Dept Paediat, Childrens Burns Unit, A-8036 Graz, Austria.
   Med Unv Graz, Dept Plast Surg, A-8036 Graz, Austria.
   Med Unv Graz, Dept Anaesthesiol, A-8036 Graz, Austria.
RP Trop, M (通讯作者)，Med Unv Graz, Dept Paediat, Childrens Burns Unit, Auenbruggerpl 30, A-8036 Graz, Austria.
EM marija.trop@meduni-graz.at
CR Banwell P, 2003, P EUR TISS REP SOC L, P73
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   HORCH R, 2000, Z FLUGWISS WELTRAUM, V13, P17
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   Malli Suzanne, 2005, Nursing, V35, P25
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 14
TC 8
Z9 8
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD NOV
PY 2006
VL 61
IS 5
BP 1267
EP 1270
DI 10.1097/01.ta.0000241149.20000.55
PG 4
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 105TB
UT WOS:000242054100043
PM 17099542
DA 2026-07-24
ER
PT J
AU Gunn, LA
   Follmar, KE
   Wong, MS
   Lettieri, SC
   Levin, LS
   Erdmann, D
AF Gunn, Laura A.
   Follmar, Keith E.
   Wong, Miehael S.
   Lettieri, Salvatore C.
   Levin, L. Seott
   Erdmann, Detlev
TI Management of enterocutaneous fistulas using negative-pressure dressings
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE enterocutaneous fistula; VAC; negative-pressure dressing;
   vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; PARENTERAL-NUTRITION; SMALL-INTESTINE;
   GASTROINTESTINAL FISTULAS; CONSERVATIVE TREATMENT; SOMATOSTATIN; SYSTEM;
   TRIAL; COMBINATION; WOUNDS
AB Fifteen patients with enterocutaneous fistulas (ECFs) not amenable to surgical treatment were treated with negative-pressure dressings over the abdominal wound and ECF. Closure of the ECF and time to closure were examined. In 11 patients who had no visible intestinal mucosa on examination, the closure rate was 100%, with a mean time to closure of 14 days. In 4 patients who did have grossly visible intestinal mucosa, no closure occurred. This represents an overall closure rate of 73%. Fistula output rate did not have a significant effect on outcome. These results confirm the efficacy of negative-pressure dressings in the closure of ECFs. Presence or absence of visible intestinal mucosa is the single most important clinical factor when considering the use of a negative-pressure dressing in the management of a patient with ECF.
C1 Duke Univ, Ctr Med, Div Plast Reconstruct Maxillofacial & Oral Surg, Dept Surg, Durham, NC 27710 USA.
C3 Duke University
RP Erdmann, D (通讯作者)，Duke Univ, Ctr Med, Div Plast Reconstruct Maxillofacial & Oral Surg, Dept Surg, POB 3181, Durham, NC 27710 USA.
EM Detlev.Erdmann@duke.edu
OI Wong, Michael/0009-0001-0628-605X
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NR 32
TC 27
Z9 31
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2006
VL 57
IS 6
BP 621
EP 625
DI 10.1097/01.sap.0000228966.13979.1c
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 109OV
UT WOS:000242318800006
PM 17122546
DA 2026-07-24
ER
PT J
AU Gomoll, AH
   Lin, A
   Harris, MB
AF Gomoll, Andreas H.
   Lin, Albert
   Harris, Mitchel B.
TI Incisional vacuum-assisted closure therapy
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE vacuum-assisted closure; wound dressing; surgical wound infection
ID SKIN-GRAFTS; BLOOD-FLOW; SURGERY; DEVICE
AB Postoperative swelling and prolonged drainage from surgical incisions result in both practical and medical burdens, such as increased need for dressing changes and potentially higher rates of surgical wound infection. This article presents a technique to apply a vacuum-assisted closure therapy sponge as a postoperative dressing to provide a clean, dry wound environment in the immediate postoperative period.
C1 Brigham & Womens Hosp, Dept Orthoped Surg, Partners Orthoped Trauma, Boston, MA 02115 USA.
   Brigham & Womens Hosp, Dept Orthoped Trauma, Partners Orthoped Trauma, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Harris, MB (通讯作者)，Brigham & Womens Hosp, Dept Orthoped Surg, Partners Orthoped Trauma, 75 Francis St, Boston, MA 02115 USA.
EM mbharris@partners.org
RI Lin, Albert/GXH-3277-2022
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NR 14
TC 119
Z9 140
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2006
VL 20
IS 10
BP 705
EP 709
DI 10.1097/01.bot.0000211159.98239.d2
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 110FH
UT WOS:000242363200009
PM 17106382
DA 2026-07-24
ER
PT J
AU Gabriel, A
   Gollin, G
AF Gabriel, Allen
   Gollin, Gerald
TI Management of complicated gastroschisis with porcine small intestinal
   submucosa and negative pressure wound therapy
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE gastroschisis; abdominal wall defects; SIS; VAC therapy; subatmospheric
   pressure therapy
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; DOG-MODEL;
   PEDIATRIC-PATIENTS; SWINE MODEL; REPAIR; BIOSCAFFOLD; EXPERIENCE;
   SYSTEM; SILO
AB Introduction: In almost all cases of gastroschisis, fascial closure may be achieved primarily or after silo reduction. Rarely, fascial and skin closure are impossible. We report our experience with visceral coverage in complicated cases of gastroschisis with porcine small intestinal submucosa (SIS) augmented by negative pressure wound therapy (NPWT).
   Methods: Over a 3-year period, 55 infants with gastroschisis were managed. In 3 of these cases, fascia and skin could not be approximated safely after complete reduction of abdominal viscera with a spring-loaded silo. Visceral coverage in each case was achieved with 0.42-mm-thickness Surgisis ES (Cook Surgical, Bloomington, Ind) that was sewn to the fascial edges. Negative pressure wound therapy was then initiated at 75 mm Hg over the exposed SIS using vacuum-assisted closure.
   Results: In each case, granulation tissue developed quickly and was followed by complete epithelialization. Two patients subsequently developed umbilical hernias.
   Conclusion: We have successfully used SIS augmented by NPWT in the management of 3 infants with complicated gastroschisis. In the rare situation in which fascial closure cannot be achieved, the combination of SIS and NPWT can provide a safe and effective means of abdominal wall closure. (c) 2006 Elsevier Inc. All rights reserved.
C1 Loma Linda Univ, Sch Med, Div Pediat Surg, Loma Linda, CA 92354 USA.
   Loma Linda Univ, Sch Med, Div Plast & Reconstruct Surg, Loma Linda, CA 92354 USA.
C3 Loma Linda University; Loma Linda University
RP Gollin, G (通讯作者)，Loma Linda Univ, Sch Med, Div Pediat Surg, Loma Linda, CA 92354 USA.
EM ggollin@llu.edu
RI Gabriel, Allen/AFK-3548-2022
CR Admire AA, 2003, PLAST RECONSTR SURG, V112, P1059, DOI 10.1097/01.PRS.0000076190.25804.B2
   Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 28
TC 34
Z9 41
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD NOV
PY 2006
VL 41
IS 11
BP 1836
EP 1840
DI 10.1016/j.jpedsurg.2006.06.050
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 110RB
UT WOS:000242395200009
PM 17101354
DA 2026-07-24
ER
PT J
AU Oomen, JWPM
   Spauwen, PHM
   Bleichrodt, RP
   van Goor, H
AF Oomen, J. W. P. M.
   Spauwen, P. H. M.
   Bleichrodt, R. P.
   van Goor, H.
TI Guideline proposal to reconstructive surgery for complex perineal sinus
   or rectal fistula
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE muscle transposition; perineal sinus; guideline; vacuum assisted closure
ID MODIFIED MARTIUS GRAFT; MYOCUTANEOUS FLAP; CROHNS-DISEASE;
   CLINICAL-EXPERIENCE; ABDOMINIS MUSCLE; CLOSURE; OMENTOPLASTY;
   PROCTECTOMY; RESECTION
AB Aim: To evaluate a guideline approach of reconstructive surgery for complex perineal sinus or rectal fistula. Methods: pre-, per-, and postoperative data of 28 patients undergoing transposition of rectus abdominis muscle (TRAM), gracilis muscle (GM), gluteal thigh flap (GTF), or omentoplasty (OP) for complex perineal sinus or rectal fistula were analyzed. A fistula higher than 10 cm and a sinus with a length of > 10 cm were treated with TRAM or OP. If < 8 cm, the first choice was GM or GTF. The operative team made choice between 8 and 10 cm. Vacuum assisted closure (VAC) therapy was used as adjunct therapy before and after muscle transposition in huge sinus. Success was defined as no residual or recurrent sinus or fistula within 6 months, post-operatively. Long-term complaints of perineum and muscle donor site were assessed. Results: Twenty-five out of 28 patients (90%) were treated according to the guideline. VAC therapy was done in six. Three patients died during mean follow up of 40 months (6-90). Initial success rate was 61% (17/28). After secondary surgery in seven, four (57%) were successful. Overall success rate, including VAC therapy, was 79% (22/28). Success was highest with GM and GTF and in small sinus or fistula. Conclusion: A guideline approach to complex perineal sinus or fistula based on length or height of the sinus or rectal fistula, respectively, is successful in about 80% of cases. Large defects may best be downsized by VAC therapy, followed by muscle flap. Long-term complaints are acceptable.
C1 Radboud Univ Nijmegen, Med Ctr, Dept Reconstruct Surg, NL-6500 HB Nijmegen, Netherlands.
   Radboud Univ Nijmegen, Med Ctr, Dept Gastrointestinal Surg, NL-6500 HB Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen
RP Oomen, JWPM (通讯作者)，Radboud Univ Nijmegen, Med Ctr, Dept Reconstruct Surg, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM judithoomen@hotmail.com
RI van+Goor, Harry/AAS-7712-2020
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NR 16
TC 18
Z9 22
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD FEB
PY 2007
VL 22
IS 2
BP 225
EP 230
DI 10.1007/s00384-006-0126-5
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 117PE
UT WOS:000242884400016
PM 16552521
DA 2026-07-24
ER
PT J
AU Sjögren, J
   Malmsjö, M
   Gustafsson, R
   Ingemansson, R
AF Sjogren, Johan
   Malmsjo, Malin
   Gustafsson, Ronny
   Ingemansson, Richard
TI Poststernotomy mediastinitis:: a review of conventional surgical
   treatments, vacuum-assisted closure therapy and presentation of the Lund
   University Hospital mediastinitis algorithm
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Review
DE mediastinitis; wound closure; thoracic surgery; review
ID STERNAL WOUND-INFECTION; OPEN-HEART-SURGERY; RIGHT-VENTRICULAR RUPTURE;
   LONG-TERM SURVIVAL; RISK-FACTORS; FLAP RECONSTRUCTION; SUCTION DRAINAGE;
   CARDIAC-SURGERY; REDON CATHETERS; MUSCLE FLAPS
AB Poststernotomy mediastinitis, also commonly called deep sternal wound infection, is one of the most feared complications in patients undergoing cardiac surgery. The overall incidence of poststernotomy mediastinitis is relatively low, between 1% and 3%, however, this complication is associated with a significant mortality, usually reported to vary between 10% and 25%. At the present time, there is no general consensus regarding the appropriate surgical approach to mediastinitis following open-heart surgery and a wide range of wound-heating strategies have been established for the treatment of poststernotomy mediastinitis during the era of modern cardiac surgery. Conventional forms of treatment usually involve surgical revision with open dressings or closed irrigation, or reconstruction with vascularized soft tissue flaps such as omentum or pectoral muscle. Unfortunately, procedure-related morbidity is relatively frequent when using conventional treatments and the tong-term clinical outcome has been unsatisfying. Vacuum-assisted closure is a novel treatment with an ingenious mechanism. This wound-heating technique is based on the application of local negative pressure to a wound. During the application of negative pressure to a sternal wound several advantageous features from conventional surgical treatment are combined. Recent publications have demonstrated encouraging clinical results, however, observations are still rather limited and the underlying mechanisms are largely unknown. This review provides an overview of the etiology and common risk factors for deep sternal wound infections and presents the historical development of conventional therapies. We also discuss the current experiences with VAC therapy in poststernotomy mediastinitis and summarize the current knowledge on the mechanisms by which VAC therapy promotes wound heating. Finally, we suggest a structured algorithm for using VAC therapy for treatment of poststernotomy mediastinitis in clinical practice. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Internal Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Sjögren, J (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
EM johan.sjogren@med.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599
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NR 86
TC 206
Z9 236
U1 0
U2 9
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD DEC
PY 2006
VL 30
IS 6
BP 898
EP 905
DI 10.1016/j.ejcts.2006.09.020
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 117WU
UT WOS:000242904800014
PM 17056269
OA Bronze
DA 2026-07-24
ER
PT J
AU Diener, H
   Wintzer, C
   Daum, H
   Debus, ES
AF Diener, Holger
   Wintzer, Christian
   Daum, Harald
   Debus, Eike Sebastian
TI Infections of chronical wounds: The diabetic foot - Systemic and local
   treatment options
SO CHIRURGISCHE GASTROENTEROLOGIE
LA German
DT Article
DE chronic wounds; ulcus entity; disturbing factors; wound infections;
   diabetic foot infections; wound healing strategies
ID OSTEOMYELITIS; ULCERS; DIAGNOSIS
AB Chronic wounds are results of various diseases. Evaluation and therapy of underlying disorders of chronic wounds must be the first step of successful wound healing. Bacterial colonization and infection of ischemic wounds and diabetic foot ulcers are limb-threatening factors. Therefore, a special therapy concept is necessary. The therapy is based on a sufficient wound bed preparation, moist wound dressings and vacuum-assisted closure ( VAC) therapy and infection control with systemic antibiotics in case of clinical infection. Another major point is the possibility of revascularization. This comprehensive wound care protocol can reduce the rate of major amputations.
C1 Asklepios Klin Harburg, Wundzentrum, Gefasszentrum, Abt Allgemein Gefass & Visceralchirurg, D-21079 Hamburg, Germany.
RP Diener, H (通讯作者)，Asklepios Klin Harburg, Wundzentrum, Gefasszentrum, Abt Allgemein Gefass & Visceralchirurg, Eissendorfer Pferdeweg 51, D-21079 Hamburg, Germany.
EM holger_diener@yahoo.de
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NR 31
TC 2
Z9 2
U1 2
U2 11
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0177-9990
J9 CHIR GASTROENTEROL
JI Chir. Gastroenterol.
PY 2006
VL 22
IS 3
BP 127
EP 137
DI 10.1159/000094583
PG 11
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 125SV
UT WOS:000243463700003
DA 2026-07-24
ER
PT J
AU Stawicki, SP
   Grossman, M
AF Stawicki, S. Peter
   Grossman, Michael
TI "Stretching" negative pressure wound therapy: Can dressing change
   interval be extended in patients with open abdomens?
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
ID CLOSURE
C1 St Lukes Hosp & Hlth Network, Dept Surg, Bethlehem, PA USA.
   Univ Penn, Trauma Network, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Stawicki, SP (通讯作者)，St Lukes Hosp & Hlth Network, Dept Surg, Bethlehem, PA USA.
OI Stawicki, Stanislaw/0000-0002-8893-6668
CR Arabi Y, 2003, CRIT CARE, V7, pR116, DOI 10.1186/cc2373
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   CARSON SN, HEALING SKIN GRAFTS
   Cipolla J, 2005, AM SURGEON, V71, P202
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   Guy JS, 2003, AM SURGEON, V69, P1025
   Reiter A, 2004, J TRAUMA, V57, P375, DOI 10.1097/01.TA.0000104016.78539.94
   Senchenkov A, 2006, UROLOGY, V67, P416, DOI 10.1016/j.urology.2005.08.037
   *V A C, 2005, THER CLIN GUID
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
NR 11
TC 11
Z9 12
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JAN
PY 2007
VL 53
IS 1
BP 26
EP 29
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 126CD
UT WOS:000243488900004
PM 17264353
DA 2026-07-24
ER
PT J
AU Morris, GS
   Brueilly, KE
   Hanzelka, H
AF Morris, G. Stephen
   Brueilly, Kevin E.
   Hanzelka, Heather
TI Negative pressure wound therapy achieved by vacuum-assisted closure:
   Evaluating the assumptions
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE topical negative pressure; wound closure; dressings; subatmospheric
   pressure; wound management
ID GROWTH-FACTOR RECEPTOR; DIABETIC FOOT; SUBATMOSPHERIC PRESSURE;
   BLOOD-FLOW
AB Wounds and the accompanying loss of skin integrity often place a patient at increased risk for disability or death. Billions of dollars are spent each year to treat wounds and the effectiveness of these different treatments is highly variable. Following a 1997 publication describing a new treatment therapy that involved creating negative pressure over the wound, many publications have described the purported mechanism of action by which negative pressure may help wounds heal. Although this therapy appears effective, it remains unknown whether it is more effective than other wound closure techniques. In addition, although many uncontrolled, non-randomized studies describing the effectiveness of this therapy have been published, few prospective randomized trials have been conducted. Small sample sizes, variable outcome measures across, studies, and significant methodological problems in the available. randomized control trials further limit the conclusions that can be drawn regarding the relative effectiveness of vacuum-assisted wound closure. Analysis of these data provides weak evidence to suggest that negative pressure therapy is superior to saline gauze dressings in healing chronic wounds. Randomized controlled trials comparing healing, costs of care, patient pain, and quality-of-life outcomes of this treatment to non-gauze type dressings and other treatment modalities are needed.
C1 Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA.
   Texas Tech Univ, Hlth Sci Ctr, Sch Allied Hlth Sci, Odessa, TX USA.
   St Davids Healthcare, Austin, TX USA.
C3 University of Texas System; UTMD Anderson Cancer Center; Texas Tech
   University System; Texas Tech University
RP Morris, GS (通讯作者)，Univ Texas, MD Anderson Canc Ctr, 1515 Holcombe Blvd, Houston, TX 77030 USA.
EM gsmorris@mdanderson.org
RI BRUEILLY, KEVIN/ABE-1106-2021
OI BRUEILLY, KEVIN/0000-0002-1717-8580
CR [Anonymous], 2004, WOUNDS, p3S
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NR 33
TC 20
Z9 24
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JAN
PY 2007
VL 53
IS 1
BP 52
EP 57
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 126CD
UT WOS:000243488900007
PM 17264356
DA 2026-07-24
ER
PT J
AU Dedmond, BT
   Kortesis, B
   Punger, K
   Simpson, J
   Argenta, J
   Kulp, B
   Morykwas, M
   Webb, LX
AF Dedmond, Barnaby T.
   Kortesis, Bill
   Punger, Kathleen
   Simpson, Jordan
   Argenta, Joseph
   Kulp, Brenda
   Morykwas, Michael
   Webb, Lawrence X.
TI The use of negative-pressure wound therapy (NPWT) in the temporary
   treatment of soft-tissue injuries associated with high-energy open
   tibial shaft fractures
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE tibia fractures; open fractures; Wound VAC; negative-pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; INTRAMEDULLARY NAILS; ANTIBIOTIC-THERAPY;
   RECONSTRUCTION; CLASSIFICATION; INFECTION; UNION; RATES; LEG
AB Objectives: To evaluate the utility of negative-pressure wound therapy (NPWT) in the setting of high-energy open tibial shaft fractures.
   Design, Setting, and Patients/Participants: This was a retrospective consecutive series in a level 1 university-based trauma center. Forty-nine consecutive patients presenting to a level 1 trauma center between 1996 and 2004 with 50 grade/type III open tibial shaft fractures were assessed.
   Intervention: The open wounds associated with each fracture were each treated with NPWT before definitive wound closure or coverage.
   Main Outcome Measurements: Infection rate, need for amputation after attempted definitive coverage, problems with bony healing requiring surgical intervention, reoperation rate after definitive coverage, and the type of definitive coverage required.
   Results: The overall infection rate for all grade/type III open fractures was 15 of 50 fractures (30%), with 11 of 50 (22%) requiring repeated surgery for infection. The infection rate was 12.5% for grade/type IIIA open fractures, 45.8% for grade/type IIIB, and 50% for grade/type IIIC. Twenty-four of 50 fractures (48%) required subsequent surgery to facilitate fracture healing. Five fractures required amputation after attempted coverage. Seven of 24 fractures initially classified as grade/type IIIA and 10 of 24 fractures initially classified as grade/type IIIB ultimately required free tissue transfer or rotational muscle flap coverage.
   Conclusions: Infection and nonunion rates with the use of NPWT for temporary coverage of wounds associated with grade/type III open tibial shaft fractures are similar to those of historical controls, but this technique may be beneficial in decreasing the need for free tissue transfer or rotational muscle flap coverage.
C1 Lexington Orthoped, W Columbia, SC 29169 USA.
   Wake Forest Univ, Dept Plast Surg, Winston Salem, NC USA.
   Wake Forest Univ, Dept Orthopaed Surg, Winston Salem, NC 27109 USA.
C3 Wake Forest University; Wake Forest University
RP Dedmond, BT (通讯作者)，Lexington Orthoped, 110 E Med Lane,Suite 220-235, W Columbia, SC 29169 USA.
EM dedmoba@yahoo.com
OI Morykwas, Michael/0009-0001-5547-5172
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NR 22
TC 109
Z9 138
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD JAN
PY 2007
VL 21
IS 1
BP 11
EP 17
DI 10.1097/BOT.0b013e31802cbc54
PG 7
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 127SK
UT WOS:000243606400003
PM 17211263
DA 2026-07-24
ER
PT J
AU Gorlitzer, M
   Grabenwoeger, M
   Meinhart, J
   Swoboda, H
   Oczenski, W
   Fiegl, N
   Waldenberger, F
AF Gorlitzer, Michael
   Grabenwoeger, Martin
   Meinhart, Johann
   Swoboda, Herwig
   Oczenski, Wolfgang
   Fiegl, Nikolaus
   Waldenberger, Ferdinand
TI Descending necrotizing mediastinitis treated with rapid sternotomy
   followed by vacuum-assisted therapy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID MANAGEMENT; INFECTIONS; SECONDARY; DRAINAGE; CLOSURE; DISEASE
AB Background. Descending necrotizing mediastinitis (DNM) is a life-threatening emergency after oropharyngeal infection. The diagnosis must be established rapidly. DNM is associated with septic shock and respiratory insufficiency. Because mortality rates may be as high as 60%, aggressive surgical treatment is indicated.
   Methods. Between December 2001 and December 2005, 5 patients ( 3 men, 2 women) with DNM, average age of 69 years ( range, 24 to 72 years), were treated at our department. Surgical treatment consisted of one or more cervical drainages and drainage of the mediastinum through sternotomy after mediastinitis had been confirmed by computed tomography. The latter investigation also revealed mediastinal abscess and empyema. After radical debridement, a vacuum-assisted closure device was inserted. Results. The outcome was favorable in 4 patients. A 72-year-old woman died of prolonged septic shock and subsequent multiple organ failure. Tracheotomy was performed in all patients to create an airway. The duration of the intensive care unit stay was 51 +/- 24.2 days.
   Conclusions. Rapid and extensive cervical and mediastinal debridement is mandatory in patients with DNM. A vacuum-assisted closure device is useful because it promotes tissue approximation and stimulates the ingrowth of granulation tissue. (c) 2007 by The Society of Thoracic Surgeons.
C1 Hosp Hietzing, Dept Cardiovasc Surg, A-1130 Vienna, Austria.
   Hosp Hietzing, Dept Otorhinolaryngol, A-1130 Vienna, Austria.
   Hosp Hietzing, Dept Anaesthesiol, A-1130 Vienna, Austria.
C3 Hietzing Hospital; Hietzing Hospital; Hietzing Hospital
RP Gorlitzer, M (通讯作者)，Hosp Hietzing, Dept Cardiovasc Surg, Wolkersbergenstr 1, A-1130 Vienna, Austria.
EM michael.gorlitzer@wienkav.at
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NR 21
TC 20
Z9 27
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD FEB
PY 2007
VL 83
IS 2
BP 393
EP 396
DI 10.1016/j.athoracsur.2006.09.059
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 129GM
UT WOS:000243716600007
PM 17257957
DA 2026-07-24
ER
PT J
AU Ferron, G
   Garrido, I
   Martel, P
   Gesson-Paute, A
   Classe, JM
   Letourneur, B
   Querleu, D
AF Ferron, Gwenael
   Garrido, Ignacio
   Martel, Pierre
   Gesson-Paute, Amelie
   Classe, Jean-Marc
   Letourneur, Benoit
   Querleu, Denis
TI Combined laparoscopically harvested omental flap with meshed skin grafts
   and vacuum-assisted closure for reconstruction of complex chest wall
   defects
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE chest wall; minimal invasive surgery; radiation therapy; wound closure;
   cancer; vacuum-assisted closure
ID STERNAL WOUND-INFECTION; CONSECUTIVE PATIENTS; GREATER OMENTUM;
   CARDIAC-SURGERY; BREAST; COVERAGE; THERAPY; TRANSPOSITION; EXPERIENCE;
   MANAGEMENT
AB Background: Chest wall reconstruction after radiation damage is a challenge in oncologic and plastic surgery. The defect can be reconstructed with laparoscopically harvested omental flap and meshed skin grafts. Our aim was to evaluate the use of vacuum-assisted closure (V.A.C.) in combination with laparoscopically harvested omental flap and meshed skin graft for treating these complex wounds.
   Methods: Between October 2003 and December 2004, 11 patients under-went a chest wall reconstruction with laparoscopic omentoplasty and V.A.C. treatment of severe chest wall radionecrosis after breast cancer treatment (n = 10) or for locally advanced breast cancer treated first by irradiation (n = 1).
   Results: Laparoscopic harvesting was uneventful in 10 cases. One patient had a laparoscopic transverse colic resection because of a middle colic artery injury. Mean time of the laparoscopic procedure was 53 minutes (range: 35-120). Wound surface area averaged 360 cm(2) (range: 80-750). The mean duration of V.A.C. treatment was 9.3 days (range: 6-16). Nine patients showed primary wound healing without adverse events. Complications occurred in 3 patients. One developed a pulmonary infection and died after healing during the postoperative course. One presented a partial flap loss, leading to delayed healing after 45 days. One patient with severe radiation damage and a complete brachial plexus paralysis required a shoulder amputation after an extensive necrosis. All but 1 patient are alive and resumed their normal daily activities.
   Conclusions: Combination of laparoscopic omentoplasty and V.A.C. can successfully be used for reconstruction of complex chest wall radiation damage.
C1 Claudius Regaud Canc Ctr, Dept Surg Oncol, F-31052 Toulouse, France.
   Rene Gauducheau Canc Ctr, Dept Surg Oncol, St Herblain, France.
   Kinet Concepts Inc, San Antonio, TX USA.
C3 UNICANCER; Universite de Toulouse (EPE); Institut Claudius Regaud;
   UNICANCER; Institut de Cancerologie de l'Ouest (ICO)
RP Ferron, G (通讯作者)，Claudius Regaud Canc Ctr, Dept Surg Oncol, 20-24 Rue Pont St Pierre, F-31052 Toulouse, France.
EM ferron.gwenael@claudiusregaud.fr
RI /P-6193-2014
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NR 42
TC 23
Z9 27
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2007
VL 58
IS 2
BP 150
EP 155
DI 10.1097/01.sap.0000237644.29878.0f
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 131FP
UT WOS:000243854100006
PM 17245140
DA 2026-07-24
ER
PT J
AU Gupta, S
   Bates-Jensen, B
   Gabriel, A
   Holloway, A
   Niezgoda, J
   Weir, D
AF Gupta, Subbas
   Bates-Jensen, Barbara
   Gabriel, Allen
   Holloway, Allen
   Niezgoda, Jeffrey
   Weir, Dot
TI Differentiating negative pressure wound therapy devices: An illustrative
   case series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; PURULENT WOUNDS;
   MANAGEMENT; DRESSINGS; ULCERS
AB Negative pressure wound therapy (NPWT) has become an important addition to the vast number of wound treatments available to the clinician. The two NPWT devices most commonly used in the United States have different components, features, and capabilities. Several cases of wounds treated with each of the two most commonly used devices are presented. Indications and evidence for use of both devices are evaluated and safety guidelines are recommended. The Loma Linda Skin and Wound Care Technology Assessment Panel commissioned the study.
C1 Loma Linda Univ, Div Plast Surg, Dept Surg, Loma Linda, CA 92354 USA.
   Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA.
   Univ Calif Los Angeles, Sch Med, Div Geriatr, Los Angeles, CA USA.
   Maricopa Cty Gen Hosp, Phoenix, AZ USA.
   Ctr Comprehens Wound Care, Milwaukee, WI USA.
   Ctr Hyperbaric Oxygen Therapy, Milwaukee, WI USA.
   Aurora Hlth Care, Milwaukee, WI USA.
   Osceola Reg Med Ctr, Kissimmee, FL USA.
C3 Loma Linda University; University of California System; University of
   California Los Angeles; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA; Maricopa County General
   Hospital
RP Gupta, S (通讯作者)，Loma Linda Univ, Div Plast Surg, Dept Surg, 11175 Campus Dr,Coleman Pavil 21126, Loma Linda, CA 92354 USA.
EM sgupta@ahs.llumc.edu
RI Gabriel, Allen/AFK-3548-2022; Niezgoda, Jeffrey/KZU-8352-2024;
   Bates-Jensen, Barbara/ABA-3726-2020
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NR 37
TC 7
Z9 17
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2007
VL 19
IS 1
SU S
BP 1
EP 9
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 133QS
UT WOS:000244028100001
DA 2026-07-24
ER
PT J
AU Rao, M
   Burke, D
   Finan, PJ
   Sagar, PM
AF Rao, M.
   Burke, D.
   Finan, P. J.
   Sagar, P. M.
TI The use of vacuum-assisted closure of abdominal wounds: a word of
   caution
SO COLORECTAL DISEASE
LA English
DT Article
DE vacuum-assisted closure; laparostomy; abdominal closure
ID FASCIAL CLOSURE; TEMPORARY CLOSURE; VENTRAL HERNIA; PACK TECHNIQUE; OPEN
   ABDOMENS; TRAUMA
AB Objective Vacuum-assisted closure (VAC) has been used in our centre to aid the closure of abdominal wounds. The aim of this study was to examine the clinical outcome of patients in whom VAC therapy had been used in conjunction with laparostomy.
   Method All patients in whom VAC was used in the management of open abdominal wounds from November 2003 to March 2005 were included in this study.
   Results There were 29 patients in the study. Nineteen (65.5%) needed ICU care. Six (20%) patients developed leakage of small bowel contents into the abdominal wound cavity because of intestinal fistulation during the VAC therapy. Four of the six (66%) died, all from multi-organ failure.
   Conclusion Our study has demonstrated a high incidence of intestinal leakage following VAC therapy. The reasons for this are multifactorial. We would recommend caution in using it on patients with bowel anastomoses or enterotomy repairs.
C1 Gen Infirm, Dept Colorectal Surg, Leeds LS1 3EX, W Yorkshire, England.
C3 Leeds General Infirmary
RP Sagar, PM (通讯作者)，Gen Infirm, Dept Colorectal Surg, Great George St, Leeds LS1 3EX, W Yorkshire, England.
EM peter.sagar@leedsth.nhs.uk
OI Burke, Dermot/0000-0002-4342-7464
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NR 12
TC 129
Z9 146
U1 0
U2 2
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1462-8910
J9 COLORECTAL DIS
JI Colorectal Dis.
PD MAR 3
PY 2007
VL 9
IS 3
BP 266
EP 268
DI 10.1111/j.1463-1318.2006.01154.x
PG 3
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 134IN
UT WOS:000244076800014
PM 17298627
DA 2026-07-24
ER
PT J
AU Weiland, DE
AF Weiland, Dennis E.
TI Fasciotomy closure using simultaneous vacuum-assisted closure and
   hyperbaric oxygen
SO AMERICAN SURGEON
LA English
DT Article
ID ISCHEMIA-REPERFUSION INJURY; NO-REFLOW PHENOMENON; SKELETAL-MUSCLE;
   BLOOD-FLOW; MICROCIRCULATION; MANAGEMENT; THERAPY
AB Fasciotomies performed for compartment syndrome and ischemic vascular disease often requires closure in 2 to 4 weeks by skin graft. This leaves the patient with an unsightly scar and a limb with reduced strength. The use of vacuum-assisted closure (VAC) and hyperbaric oxygen therapy (HBOT) quickly reduce the edema and permit earlier closure with adjacent skin. A study of three trauma patients with compartment syndrome, fasciotomies, and the use of the VAC and HBOT to close the fasciotomy wounds with adjacent skin is presented. The pathophysiology of compartment syndrome and ischemia-reperfusion syndrome is discussed. These patients had closure of the fasciotomy wounds in 3 to 18 days. The simultaneous use of HBOT and VAC accelerates the reduction of edema in a synergistic fashion, permitting early closure of fasciotomy wounds.
C1 Scottsdale Healthcare, Scottsdale, AZ USA.
C3 Scottsdale Healthcare Osborn
RP Weiland, DE (通讯作者)，11779 N 114th Way, Scottsdale, AZ 85259 USA.
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NR 24
TC 11
Z9 15
U1 0
U2 2
PU SOUTHEASTERN SURGICAL CONGRESS
PI ATLANTA
PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA
SN 0003-1348
J9 AM SURGEON
JI Am. Surg.
PD MAR
PY 2007
VL 73
IS 3
BP 261
EP 266
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 139LF
UT WOS:000244432600013
PM 17375783
DA 2026-07-24
ER
PT J
AU Berkowitz, J
   Rediske, WR
   Chance, J
   Kim, DH
AF Berkowitz, Jacob
   Rediske, William R.
   Chance, John
   Kim, David H.
TI Technique tip: Creation of a vacuum-assisted closure system for wound
   management in an austere environment
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
ID NEGATIVE-PRESSURE; SUBATMOSPHERIC PRESSURE; SKIN-GRAFTS; EXPERIENCE;
   DRESSINGS; THERAPY; TRIAL
C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA.
   Darnall Army Community Hosp, Ft Hood, TX USA.
   Kaiser Permanente, Denver, CO USA.
C3 United States Department of Defense; United States Army; Tripler Army
   Medical Center; Kaiser Permanente
RP Berkowitz, J (通讯作者)，Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM mark.j.berkowitz@us.army.mil
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   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
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   Joseph E, 2000, WOUNDS, V12, P60
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NR 14
TC 4
Z9 4
U1 0
U2 0
PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC
PI SEATTLE
PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA
SN 1071-1007
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD MAR
PY 2007
VL 28
IS 3
BP 388
EP 391
DI 10.3113/FAI.2007.0388
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 140WF
UT WOS:000244536700018
PM 17371665
DA 2026-07-24
ER
PT J
AU Abai, B
   Zickler, RW
   Pappas, PJ
   Lal, BK
   Padberg, FT
AF Abai, Babak
   Zickler, Robert W.
   Pappas, Peter J.
   Lal, Brajesh K.
   Padberg, Frank T., Jr.
TI Lymphorrhea responds to negative pressure wound therapy
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 18th Annual Meeting of the American-Venous-Forum
CY FEB 22-26, 2006
CL Miami, FL
SP Amer Venous Forum
ID VACUUM-ASSISTED CLOSURE; LYMPHATIC COMPLICATIONS; ISOSULFAN BLUE
AB Lymphoceles and lymph fistulas are common complications of femoral exposure for vascular procedures. Three patients who required readmission after their vascular interventions were treated with negative pressure wound therapy. Once adequate control of the drainage was obtained, the patients were discharged home with a portable suction unit. The mean time to stop lymph leak was 14 days, and the mean length of hospital stay was 7.3 days. This method of management offers early control of fluid drainage, rapid control of the wound, earlier closure, and the potential for reduced length of stay. Patient acceptance and convenience may be enhanced by outpatient management and return to work in appropriately motivated individuals.
C1 Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Sect Vasc Surg, E Orange, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Padberg, FT (通讯作者)，Doctors Off Ctr, 90 Bergen St,Suite 7200, Newark, NJ 07103 USA.
EM PadbergJr@aol.com
RI ; Lal, Brajesh/AAA-2620-2022
OI Padberg, Frank/0000-0001-5067-4247; Abai, Babak/0000-0003-1529-1712
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
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NR 12
TC 46
Z9 53
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD MAR
PY 2007
VL 45
IS 3
BP 610
EP 613
DI 10.1016/j.jvs.2006.10.043
PG 4
WC Surgery; Peripheral Vascular Disease
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 141AH
UT WOS:000244547900035
PM 17321350
DA 2026-07-24
ER
PT J
AU Grimm, A
   Dimmler, A
   Stange, S
   Labanaris, A
   Sauer, R
   Grabenbauer, G
   Horch, RE
AF Grimm, Andreas
   Dimmler, Arno
   Stange, Sebastian
   Labanaris, Apostolos
   Sauer, Rolf
   Grabenbauer, Gerhard
   Horch, Raymund E.
TI Expression of HIF-1α in irradiated tissue is altered by topical
   negative-pressure therapy
SO STRAHLENTHERAPIE UND ONKOLOGIE
LA English
DT Article
DE irradiation; tissue oxygenation; topical negative-pressure therapy;
   HIF-1 alpha
ID VACUUM-ASSISTED CLOSURE; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL GROWTH-FACTOR;
   INDUCIBLE FACTOR-I; RECONSTRUCTIVE SURGERY; WOUND CONTROL; NECK-SURGERY;
   HYPOXIA; FLAPS; VASCULARIZATION
AB Background and Purpose: Despite the enormous therapeutic potential of modern radiotherapy, common side effects such as radiation-induced wound healing disorders remain a well-known clinical phenomenon. Topical negative pressure therapy (TNP) is a novel tool to alleviate intraoperative, percutaneous irradiation or brachytherapy. Since TNP has been shown to positively influence the perfusion of chronic, poorly vascularized wounds, the authors applied this therapeutic method to irradiated wounds and investigated the effect on tissue oxygenation in irradiated tissue in five patients.
   Material and Methods: With informed patients' consent, samples prior to and 4 and 8 days after continuous TNP with -125 mmHg were obtained during routine wound debridements. Granulation tissue was stained with hematoxylin-eosin, and additionally with CD31, HIF-1 alpha (hypoxia-inducible factor-1 alpha), and D2-40 to detect blood vessels, measure indirect signs of hypoxia, and lymph vessel distribution within the pre- and post-TNP samples.
   Results: In this first series of experiments, a positive influence of TNP onto tissue oxygenation in radiation-induced wounds could be demonstrated. TNP led to a significant decrease of 53% HIF-1 alpha-positive cell nuclei. At the same time, a slight reduction of CD31-stained capillaries was seen in comparison to samples before TNP. Immunostaining with D2-40 revealed an increased number of lymphatic vessels with distended lumina and an alteration of the parallel orientation within the post-TNP samples.
   Conclusion: This study is, to the authors' knowledge, the first report on a novel previously not described histological marker to demonstrate the effects of TNP on HIF-1 alpha expression as an indirect marker of tissue oxygenation in irradiated wounds, as demonstrated by a reduction of HIF-1 alpha concentration after TNP. Since this observation may be of significant value to develop possible new strategies to treat radiation-induced tissue injury, further investigations of HIF-1 alpha regulation under TNP are warranted.
C1 Univ Erlangen Nurnberg, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
   Univ Erlangen Nurnberg, Dept Pathol, D-91054 Erlangen, Germany.
   Univ Erlangen Nurnberg, Dept Radiat Oncol, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM Raymund.Horch@chir.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
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NR 44
TC 24
Z9 26
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0179-7158
EI 1439-099X
J9 STRAHLENTHER ONKOL
JI Strahlenther. Onkol.
PD MAR
PY 2007
VL 183
IS 3
BP 144
EP 149
DI 10.1007/s00066-007-1560-1
PG 6
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 143MC
UT WOS:000244725200006
PM 17340073
DA 2026-07-24
ER
PT J
AU Kotsis, T
   Lioupis, C
AF Kotsis, T.
   Lioupis, Chr.
TI Use of vacuum assisted closure in vascular graft infection confined to
   the groin
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE vacuum assisted closure; groin wounds; wound healing complications;
   vascular graft infection; lymphatic fistula
ID TOPICAL NEGATIVE-PRESSURE; ROTATIONAL MUSCLE FLAPS; LYMPHATIC FISTULA;
   WOUND THERAPY; MANAGEMENT; SURGERY; RECONSTRUCTION; COVERAGE; SALVAGE;
   BYPASS
AB Purpose : In this report we share our experience with the use of the VAC system as a less invasive means of graft preservation and an effective alternative to routine muscle flap closure, in patients with groin wound healing complications following lower limb vascular procedures. We also review the English literature regarding the use of VAC therapy on infected groin wounds when the infection affects the prosthesis.
   Patients and Methods : eight patients treated with delayed healing of a groin incision following a femoral artery surgery. In six cases local exploration or CT examination showed evidence of graft involvement (Szilagyi grade III).
   Results : Mean duration of VAC use was 21.5 days (range, 10 to 45). The wounds were filled with granulation tissue by day 10 with no purulent-inflammatory exudates. At the end of VAC therapy, final closure was easily achieved by either healing by secondary intention or delayed primary closure. No patient required use of muscle flaps. There were no reinfections at 1 to 28 month follow-up (mean, 17.2 months/ one case lost to follow-up).
   Conclusion : Our initial experience with VAC therapy to treat non healing groin wounds following vascular reconstructions is very promising. Negative pressure therapy resulted in control lymph leakage, achieving healing and managing infection.
C1 Univ Athens, Aretaeion Hosp, Sch Med, Surg Clin 2,Dept Vasc Surg, Athens, Greece.
   Red Cross Hosp Athens, Dept Vasc Surg, Athens, Greece.
C3 National & Kapodistrian University of Athens
RP Kotsis, T (通讯作者)，Univ Athens, Aretaeion Hosp, Sch Med, Surg Clin 2,Dept Vasc Surg, Vas Sophias 76, Athens, Greece.
EM kotsisth@otenet.gr
OI Lioupis, Christos/0000-0001-6197-3218
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NR 36
TC 24
Z9 28
U1 0
U2 2
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD FEB
PY 2007
VL 107
IS 1
BP 37
EP 44
DI 10.1080/00015458.2007.11680008
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 146TF
UT WOS:000244956900006
PM 17405596
DA 2026-07-24
ER
PT J
AU Jerome, D
AF Jerome, Donnalee
TI Advances in negative pressure wound therapy - The VAC instill
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
ID ASSISTED CLOSURE
AB Acute and chronic wounds affect millions of patients. Negative pressure wound therapy (NPWT) has been available for several decades, and it has significantly impacted treatment of multiple types of wounds. The vacuum-assisted closure (VAC) system has recently been modified, allowing intermittent instillation of fluids into wounds. A description of the system, guidelines for use and novel application techniques developed by the author are discussed.
C1 Scottsdale Hlth Care, Scottsdale, AZ 85251 USA.
C3 Scottsdale Healthcare Osborn
RP Jerome, D (通讯作者)，Scottsdale Hlth Care, 7400 E Osborn Rd, Scottsdale, AZ 85251 USA.
EM Djerome@SHC.org
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NR 16
TC 31
Z9 38
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAR-APR
PY 2007
VL 34
IS 2
BP 191
EP 194
DI 10.1097/01.WON.0000264834.18732.3b
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 150VV
UT WOS:000245248600014
PM 17413837
DA 2026-07-24
ER
PT J
AU Holle, G
   Germann, G
   Sauerbier, M
   Riedel, K
   von Gregory, H
   Pelzer, M
AF Holle, G.
   Germann, G.
   Sauerbier, M.
   Riedel, K.
   von Gregory, H.
   Pelzer, M.
TI Vacuum-assisted closure therapy and wound coverage in soft tissue injury
SO UNFALLCHIRURG
LA German
DT Article
DE VAC therapy; long-term treatment; acute soft tissue defect; plastic and
   reconstructive surgery; chronic wounds
ID NEGATIVE-PRESSURE DRESSINGS; SUBATMOSPHERIC PRESSURE; SKIN-GRAFTS;
   MANAGEMENT; RECONSTRUCTION; FRACTURES; DEVICE; TRAUMA
AB This study presents the results of a meta-analysis based on the literature dealing with the clinical applications of vacuum-assisted closure (VAC) in the areas of chronic wounds, acute posttraumatic wounds, compartment syndromes, or injuries of the upper extremities. The studies were analysed for validity, significance of conclusion with respect to success rate, publications, and economic efficacy.
   The data show that with VAC a very valuable technique has been added to an integrated therapeutic concept of soft tissue reconstruction. However, clinical data from prospective randomised trials to support some of the positive aspects seen in the daily clinical application of the technique are still missing. These would create a sound basis demonstrating the economic efficacy of the technique.
C1 Heidelberg Univ, Klin Plast & Handchirurg,Schwerbrandverletztenzen, Berufsgenossenschaftliche Unfallklin, Klin Hand Plast & Rekonstrukt Chirurg, D-67071 Ludwigshafen, Germany.
   St Markus Hosp, Klin Plast Chirurg Wiederherstellungs & Handchiru, Frankfurt, Germany.
C3 Ruprecht Karls University Heidelberg
RP Germann, G (通讯作者)，Heidelberg Univ, Klin Plast & Handchirurg,Schwerbrandverletztenzen, Berufsgenossenschaftliche Unfallklin, Klin Hand Plast & Rekonstrukt Chirurg, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
EM guenter.germann@urz.uni-heidelberg.de
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NR 29
TC 20
Z9 20
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD APR
PY 2007
VL 110
IS 4
BP 289
EP 300
DI 10.1007/s00113-007-1265-z
PG 12
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 156SN
UT WOS:000245670000001
PM 17404700
DA 2026-07-24
ER
PT J
AU Dedmond, BT
   Kortesis, B
   Punger, K
   Simpson, J
   Argenta, J
   Kulp, B
   Morykwas, M
   Webb, LX
AF Dedmond, Barnaby T.
   Kortesis, Bill
   Punger, Kathleen
   Simpson, Jordan
   Argenta, Joseph
   Kulp, Brenda
   Morykwas, Michael
   Webb, Lawrence X.
TI Subatmospheric pressure dressings in the temporary treatment of soft
   tissue injuries associated with type III open tibial shaft fractures in
   children
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE open fracture; tibia fracture; pediatric fracture; pediatric limb
   trauma; limb salvage
ID VACUUM-ASSISTED CLOSURE; ANTIBIOTIC-THERAPY; LOWER-EXTREMITY; WOUND
   CONTROL; RECONSTRUCTION; MANAGEMENT; CLASSIFICATION; COMPLICATIONS;
   EXPERIENCE; INFECTION
AB Purpose: This study was designed to evaluate the use of subatmospheric pressure dressings on high-energy open tibial shaft fractures in children. We hypothesized that the use of a negative-pressure dressing in these fractures would result in a decreased incidence of infection and decreased need for pedicled muscle flaps and free tissue transfer.
   Methods: A retrospective case series of 15 consecutive pediatric patients with 16 type III open tibial shaft fractures (8 type I IIA, 7 type IIIB, and I type I IIC). The patients' age ranged from 2 to 17 years. All patients underwent a standard protocol of serial irrigation and debridement of the open wound with bony stabilization. Temporary coverage of the open wound was obtained with the use of a subatmospheric pressure dressing until definitive wound coverage or closure.
   Results: Infection occurred in 5 of 16 fractures, 2 requiring antibiotics alone (1 type IIIA and 1 type IIIB) and 3 requiring surgical intervention (2 type IIIB and 1 type IIIC). Seven of 16 (3 type IIIA, 3 type IIIB, and 1 type IIIC) fractures required repeat surgical intervention to facilitate bony healing. Only 3 patients required free tissue transfers or rotational muscle flaps for coverage, a 50% decrease compared with the initial classification.
   Conclusions: Compared with other described methods, the use of subatmospheric pressure dressings in the temporary treatment of soft tissue wounds associated with high-energy open tibial shaft may reduce the need for major soft tissue coverage procedures. Its effect on infection and fracture healing rates requires further study.
   Significance: A reduction in the need for major soft tissue coverage procedures with the use of negative-pressure dressings in this setting should result in decreased morbidity for these patients and in decreased social and financial costs.
C1 Lexington Orthopaed, W Columbia, SC 29169 USA.
   Wake Forest Univ, Dept Orthopaed Surg, Winston Salem, NC 27109 USA.
   Wake Forest Univ, Dept Plast Surg, Winston Salem, NC 27109 USA.
C3 Wake Forest University; Wake Forest University
RP Dedmond, BT (通讯作者)，Lexington Orthopaed, 110 E Med Lane,Suites 220 & 235, W Columbia, SC 29169 USA.
EM dedmoba@yahoo.com
OI Morykwas, Michael/0009-0001-5547-5172
CR Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
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NR 29
TC 45
Z9 58
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-6798
EI 1539-2570
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD NOV-DEC
PY 2006
VL 26
IS 6
BP 728
EP 732
DI 10.1097/01.bpo.0000242434.58316.ad
PG 5
WC Orthopedics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Pediatrics
GA 157CB
UT WOS:000245695100006
PM 17065934
DA 2026-07-24
ER
PT J
AU Kim, EK
   Hong, JP
AF Kim, Eun Key
   Hong, Joon Pio
TI Efficacy of negative pressure therapy to enhance take of 1-stage
   allodermis and a split-thickness graft
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE 1-stage allodermis and split-thickness skin graft; negative pressure
   therapy
ID VACUUM-ASSISTED CLOSURE; RADIAL FOREARM FLAP; DONOR-SITE; WOUND CONTROL;
   SKIN-GRAFTS; DRESSINGS; MORBIDITY
AB Negative pressure therapy has been used in various conditions to promote wound healing. It has also been used to secure a skin graft by improving microcirculation and providing tight adhesion between the graft and the recipient bed. The authors coupled the idea of negative pressure therapy for 1-stage allodermis and a split-thickness skin graft. This prospective study presents 47 cases of skin defects treated by I-stage allodermis and a split-thickness skin graft. The patients were divided into 2 groups either treated with simultaneous aid of negative pressure therapy for 5 days (group 1, n = 37) or a classic tieover dressing (group 2, n = 10). In group 1, 97.8% graft take was noted at day 5 and the mean time until complete healing was 5.8 days. In group 2, 84% graft take was noted at day 5 and mean time until complete healing was 8.9 days with an average number of 3.2 dressings. Statistically significant graft take (day 5) and time until complete healing was noted (P < 0.05). Good aesthetic and functional result mimicking a full-thickness skin graft was achieved in both groups. However, frequent dressings, longer time to heal, and more restriction to the graft site were needed for group 2. Split-thickness skin added to allodermis provided a sufficient amount of dermis to prevent contracture, and the negative pressure therapy ensured fast and complete take of the 2-layered composite graft. This option can be used to achieve healing mimicking a full-thickness skin graft without requiring large full-thickness donor sites.
C1 Univ Ulsan, Coll Med, Dept Plast & Reconstruct Surg, Asan Med Ctr, Seoul 138736, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Hong, JP (通讯作者)，Univ Ulsan, Coll Med, Dept Plast & Reconstruct Surg, Asan Med Ctr, 388-1 PungNap-2Dong, Seoul 138736, South Korea.
EM joonphong@amc.seoul.kr
RI Hong, Joon/AEV-0712-2022
CR [Anonymous], BR J PLAST SURG
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 29
TC 59
Z9 68
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2007
VL 58
IS 5
BP 536
EP 540
DI 10.1097/01.sap.0000245121.32831.47
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 161RK
UT WOS:000246033000013
PM 17452839
DA 2026-07-24
ER
PT J
AU Hanasono, MM
   Skoracki, RJ
AF Hanasono, Matthew M.
   Skoracki, Roman J.
TI Securing skin grafts to microvascular free flaps using the
   vacuum-assisted closure (VAC) device
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE microvascular free flap; negative pressure dressing; vacuum-assisted
   closure (VAC) device
ID NEGATIVE-PRESSURE DRESSINGS; WOUND CONTROL; BOLSTER
AB We performed microvascular free muscle flaps on 5 patients using the vacuum-assisted closure (VAC) device (KCI, San Antonio, TX) to secure a split-thickness skin graft to the external surface of the flap in each case. This method of skin-graft fixation was selected in each case because of the complex 3-dimensional shape of the flap or because of concerns of inadequate fixation provided by conventional tie-over bolster techniques in regions that experience a significant amount of shear stress. All 5 flaps remained viable throughout the treatment course and all 5 patients experienced excellent skin-graft take. Also, decreased edema was noted in all 5 flaps. We conclude that the VAC device is a useful tool in the fixation of skin grafts to microvascular free flaps and that its use does not compromise free-flap viability.
C1 Univ Texas, MD Anderson Canc Ctr, Dept Plast Surg, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center
RP Hanasono, MM (通讯作者)，Univ Texas, MD Anderson Canc Ctr, Dept Plast Surg, 1515 Holcombe Blvd, Houston, TX 77030 USA.
EM mhanasono@mdanderson.org
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Evans D, 2001, BRIT J PLAST SURG, V54, P238, DOI 10.1054/bjps.2001.3547
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
NR 8
TC 53
Z9 63
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2007
VL 58
IS 5
BP 573
EP 576
DI 10.1097/01.sap.0000237638.93453.66
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 161RK
UT WOS:000246033000020
PM 17452846
DA 2026-07-24
ER
PT J
AU de Weerd, L
   Kjoeve, J
   Aghajani, E
   Elvenes, OP
AF de Weerd, Louis
   Kjoeve, Jorn
   Aghajani, Ebrahim
   Elvenes, Odd P.
TI The sandwich design - A new method to close a high-output
   enterocutaneous fistula and an associated abdominal wall defect
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE enterocutaneous fistula; free flap; vacuum-assisted closure system
ID GASTROINTESTINAL FISTULAS; LATISSIMUS-DORSI; MANAGEMENT; EXPERIENCE;
   NUTRITION; SURGERY; SYSTEM
AB Fistulas draining through large abdominal wall defects are exceptionally difficult to treat and are associated with a very high mortality. This case report describes a new method for closure of these fistulas where prior conservative and surgical treatment had failed. Initial use of a vacuum-assisted closure (VAC) system optimized wound care and led to coverage of the exposed intestines with granulation tissue. The serratus muscle of a composite free latissimus dorsi-serratus flap was used to close the fistula, while the large abdominal wall defect was closed with the musculocutaneous latissimus dorsi flap. Temporary placement of a VAC system between the serratus muscle and the latissimus dorsi muscle immobilized the serratus to the fistula and counteracted changes in abdominal pressure. The layering of muscle, VAC system, and muscle resembles a sandwich. The advantage of the sandwich design is an extraperitoneal approach that provides tension-free closure of the fistula and abdominal wall, with well-vascularized tissue.
C1 Univ Hosp N Norway, Tromso, Norway.
C3 UiT The Arctic University of Tromso; University Hospital of North Norway
RP de Weerd, L (通讯作者)，Dept Plast & Reconstruct Surg & Hand Surg, Sykehus Veien 38,POB 66, N-9038 Tromso, Norway.
EM louis.deweerd@unn.no
OI Aghajani, Ebrahim/0000-0002-4383-9581
CR Berry SM, 1996, SURG CLIN N AM, V76, P1009, DOI 10.1016/S0039-6109(05)70495-3
   Cro C, 2002, POSTGRAD MED J, V78, P364, DOI 10.1136/pmj.78.920.364
   Dudrick SJ, 1999, WORLD J SURG, V23, P570, DOI 10.1007/PL00012349
   Erdmann D, 2001, PLAST RECONSTR SURG, V108, P2066, DOI 10.1097/00006534-200112000-00036
   FRANCESCHI N, 1991, ANN PLAS SURG, V27, P121, DOI 10.1097/00000637-199108000-00005
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   Hollington P, 2004, BRIT J SURG, V91, P1646, DOI 10.1002/bjs.4788
   Hyon SH, 2000, ASAIO J, V46, P511, DOI 10.1097/00002480-200007000-00028
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NR 14
TC 11
Z9 11
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2007
VL 58
IS 5
BP 580
EP 583
DI 10.1097/01.sap.0000237643.45125.8b
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 161RK
UT WOS:000246033000022
PM 17452848
DA 2026-07-24
ER
PT J
AU Jones, GA
   Butler, J
   Lieberman, I
   Schlenk, R
AF Jones, G. Alexander
   Butler, John
   Lieberman, Isador
   Schlenk, Richard
TI Negative-pressure wound therapy in the treatment of complex
   postoperative spinal wound infections: complications and lessons learned
   using vacuum-assisted closure.
SO JOURNAL OF NEUROSURGERY-SPINE
LA English
DT Article
DE postoperative spinal wound infection; complication; negative-pressure
   wound therapy; vacuum-assisted closure
ID MANAGEMENT; SURGERY; DEVICE; CARE
AB Object. Deep infections of the spine are a significant cause of morbidity and death. Such infections complicate 0.7 to 11.9% of spinal procedures. Management includes intravenous antibiotic therapy, debridement and irrigation with primary closure, placement of drains, use of irrigation systems, and/or healing through secondary intention with wound packing. Vacuum-assisted closure (VAC is a new alternative for treatment of patients with complex postoperative spinal infections. The aim of this study was to investigate the safety of this treatment method in this patient population.
   Methods. The authors reviewed the charts of 16 consecutive patients treated with negative-pressure wound therapy at their institution between 2002 and 2006. All had deep infections of the spine and were treated with surgical debridement and placement of VAC dressings. All infections were postoperative. Members of the infectious disease service were involved in the care of all patients, and all patients received intravenous antibiotic therapy. The authors reviewed operative notes, discharge summaries, and notes from follow-up visits and assessed outcome on the basis of the same records.
   Three patients were lost to follow up, leaving a group of 13 with follow up of at least 90 days. Two patients experienced bleeding complications related to the continuous negative pressure of the VAC device. In two cases, the infections persisted and required reoperation. In one case, a skin graft was required because of nonhealing granulation tissue. One of the patients with bleeding complications died as a result of delayed complications related to intraoperative blood loss, blood loss via the VAC system, and refusal of a blood transfusion on religious grounds.
   Conclusions. Negative-pressure wound therapy has been employed as a treatment strategy for patients with complex postoperative spinal infections, but little is known of the complications associated with VAC in the spinal surgery patient population. Serious complications, including death, may be associated with use of the VAC system.
C1 Cleveland Clin, Cleveland Clin Spine Inst, Cleveland, OH 44106 USA.
C3 Cleveland Clinic Foundation
RP Schlenk, R (通讯作者)，Cleveland Clin, Cleveland Clin Spine Inst, Cleveland, OH 44106 USA.
EM schlenr@ccf.org
RI Schlenk, Richard/AAG-3218-2019
OI Jones, G Alexander/0000-0002-0009-5463
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P E, 1999, J Wound Care, V8, P79
   Beiner JM, 2003, NEUROSURG FOCUS, V15, pE14
   Calderone RR, 1996, ORTHOP CLIN N AM, V27, P171
   Cardo D, 2004, AM J INFECT CONTROL, V32, P470, DOI 10.1016/j.ajic.2004.10.001
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Fox A, 2004, J Wound Care, V13, P344
   Friedman T, 2005, ANN PLAS SURG, V55, P420, DOI 10.1097/01.sap.0000174361.52084.6e
   Fuchs U, 2005, ANN THORAC SURG, V79, P526, DOI 10.1016/j.athoracsur.2004.08.032
   Gwan-Nulla DN, 2001, ANN PLAS SURG, V47, P552, DOI 10.1097/00000637-200111000-00014
   Labler L, 2006, EUR SPINE J, V15, P1388, DOI 10.1007/s00586-006-0164-2
   Mehbod AA, 2005, J SPINAL DISORD TECH, V18, P14, DOI 10.1097/01.bsd.0000133493.32503.d3
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
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   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
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   Yuan-Innes M J, 2001, Spine (Phila Pa 1976), V26, pE30
NR 21
TC 58
Z9 68
U1 0
U2 4
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI CHARLOTTESVILLE
PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 USA
SN 1547-5654
J9 J NEUROSURG-SPINE
JI J. Neurosurg.-Spine
PD MAY
PY 2007
VL 6
IS 5
BP 407
EP 411
DI 10.3171/spi.2007.6.5.407
PG 5
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 161WS
UT WOS:000246048100005
PM 17542505
DA 2026-07-24
ER
PT J
AU Denzinger, S
   Lübke, L
   Roessler, W
   Wieland, WF
   Kessler, S
   Burger, M
AF Denzinger, Stefan
   Luebke, Lars
   Roessler, Wolfgang
   Wieland, Wolf F.
   Kessler, Sigurd
   Burger, Maximilian
TI Vacuum-assisted closure versus conventional wound care in the treatment
   of wound failures following inguinal lymphadenectomy for penile cancer::
   A retrospective study
SO EUROPEAN UROLOGY
LA English
DT Article
DE inguinal lymphadenectomy; penile cancer; vacuum-assisted closure; wound
   failure
ID SQUAMOUS-CELL CARCINOMA; SENTINEL NODE BIOPSY; SUBATMOSPHERIC PRESSURE;
   GROIN; COMPLICATIONS
AB Objectives: Impaired wound healing is a frequent event in inguinal surgery and very common after lymphadenectomy for penile cancer. Although vacuum therapy has been reported to expedite the healing of complex wound failures, vacuum-assisted closure (VAC) has been reported to be contraindicated in malignancy. In the present study we evaluated the use of VAC in the treatment of complex wound failures following inguinal lymphadenectomy for penile cancer in comparison to conventional wound care (CWC) implying debridement and saline-soaked gauze.
   Methods: We retrospectively identified six inguinal wounds following inguinal lymphadenectomy for penile cancer and subsequent use of VAC from 2003 to 2006 at our institution. Data on surgical interventions, complications, length of time required for closure, and outcome were compared to 10 inguinal defects treated with CWC between 2000 and 2003.
   Results: Wound volume was comparable for both groups. Wound breakdown occurred at a median of 7.4 d after inguinal lymphadenectomy and was treated by CWC for a mean of 69.8 d. In the VAC group, the median duration until complete closure was 38.9 d. Thus, VAC was shown to result in complete wound, healing in less time (p < 0.001). No local recurrence in the VAC group was noted despite positive lymph nodes.
   Conclusions: VAC therapy is effective in complex inguinal wound failures following lymphadenectorny for penile cancer and appears to be superior to CWC. VAC seems to offer adequate safety concerning local recurrence. (c) 2006 European Association of Urology. Published by Elsevier B.V. All rights reserved.
C1 Univ Regensburg, Dept Urol, D-93053 Regensburg, Germany.
   Univ Munich, Dept Surg, Munich, Germany.
C3 University of Regensburg; University of Munich
RP Burger, M (通讯作者)，Univ Regensburg, Caritas Krankenhaus St Josef, Urol Klin, Landshuterstr 65, D-93053 Regensburg, Germany.
EM maximilian.burger@klinik.uni-regensburg.de
CR Algaba F, 2002, EUR UROL, V42, P199, DOI 10.1016/S0302-2838(02)00308-1
   AlSalman MMS, 1997, INT SURG, V82, P60
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bevan-Thomas R, 2002, J UROLOGY, V167, P1638, DOI 10.1016/S0022-5347(05)65169-5
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NR 24
TC 14
Z9 16
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0302-2838
EI 1873-7560
J9 EUR UROL
JI Eur. Urol.
PD MAY
PY 2007
VL 51
IS 5
BP 1320
EP 1325
DI 10.1016/j.eururo.2006.12.027
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 161YP
UT WOS:000246053400027
PM 17207916
DA 2026-07-24
ER
PT J
AU Petzina, R
   Ugander, M
   Gustafsson, L
   Engblom, H
   Sjögren, J
   Hetzer, R
   Ingemansson, R
   Arheden, H
   Malmsjö, M
AF Petzina, Rainer
   Ugander, Martin
   Gustafsson, Lotta
   Engblom, Henrik
   Sjogren, Johan
   Hetzer, Roland
   Ingemansson, Richard
   Arheden, Hakan
   Malmsjo, Malin
TI Hemodynamic effects of vacuum-assisted closure therapy in cardiac
   surgery:: Assessment using magnetic resonance imaging
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID MEDIAN STERNOTOMY INCISION; PERISTERNAL THORACIC WALL; STERNAL
   WOUND-INFECTION; OPEN-HEART PROCEDURES; BLOOD-FLOW; POSTSTERNOTOMY
   MEDIASTINITIS; AGGRESSIVE MANAGEMENT; EARLY INTERVENTION;
   CATHETERIZATION; VALIDATION
AB Objective: The hemodynamic effects of vacuum-assisted closure therapy in cardiac surgery are debated. The aim of the present study was to quantify cardiac output and left ventricular chamber volumes after vacuum-assisted closure using magnetic resonance imaging, which is known to be the most accurate method for quantifying these measures.
   Methods: Six pigs had median sternotomy followed by vacuum-assisted closure treatment in the presence and absence of a paraffin gauze interface dressing. Cardiac output and stroke volume were examined using magnetic resonance imaging flow quantification (breath-hold and real-time). Chamber volumes were assessed using cine magnetic resonance imaging.
   Results: Cardiac output and stroke volume decreased immediately after application of negative pressures of 75, 125, and 175 mm Hg (13% +/- 1% decrease in cardiac output). Interposition of 4 layers of paraffin gauze dressing over the heart during vacuum-assisted closure therapy resulted in a smaller decrease in cardiac output (8% +/- 1%).
   Conclusions: Vacuum-assisted closure therapy results in an immediate decrease in cardiac output, although to a lesser extent than shown previously. Covering the heart with a wound interface dressing lessens the hemodynamic effects of vacuum-assisted closure.
C1 Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Clin Physiol, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   German Heart Inst, Berlin, Germany.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital; German
   Heart Center Berlin
RP Malmsjö, M (通讯作者)，Lund Univ, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Ugander, Martin/AAQ-4447-2021; Sjögren, Johan/AAZ-6448-2021
OI Ugander, Martin/0000-0003-3665-2038; Maljö, Malin/0000-0001-9849-9599;
   Gustafsson, Lotta/0000-0002-9826-9133; Ingemansson,
   Richard/0000-0001-7623-8953; Petzina, Rainer/0000-0002-0688-5482; 
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   *SON CORP, SON PROD INF
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NR 28
TC 38
Z9 43
U1 0
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD MAY
PY 2007
VL 133
IS 5
BP 1154
EP 1162
DI 10.1016/j.jtcvs.2007.01.011
PG 9
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 162BU
UT WOS:000246062300006
PM 17467423
OA Bronze
DA 2026-07-24
ER
PT J
AU Zutt, M
   Haas, E
   Krüger, U
   Distler, M
   Neumann, C
AF Zutt, Markus
   Haas, Ellen
   Krueger, Ullrich
   Distler, Meike
   Neumann, Christine
TI Successful use of vacuum-assisted closure therapy for leg ulcers caused
   by occluding vasculopathy and inflammatory vascular diseases -: A case
   series
SO DERMATOLOGY
LA English
DT Article
DE vacuum-assisted closure; leg ulcus; vasculitis; vaso-occlusion
ID WOUND MANAGEMENT
AB Background: Leg ulcers caused by vasculitis, small vessel occlusion or other rare conditions often prove to be very difficult to treat. Despite polypragmatic, systemic and localized therapy, many of these wounds are progressive and characterized by severe pain. Methods and Results: We here portray the cases of 5 patients with ulcers resistant to systemic therapy for the underlying disease, who were treated successfully using vacuum-assisted closure ( VAC) for wound management. We present the advantages and disadvantages of this method, as well as illustrating the essential and known therapeutic principles. Conclusions: Our experience shows VAC to be an excellent and effective alternative in the treatment of therapy-resistant chronic wounds caused by vasculopathy (small vessel occlusion or vasculitis). We did not observe any pathergy or proinflammatory effects caused by VAC. Copyright (c) 2007 S. Karger AG, Basel
C1 Univ Gottingen, Abt Dermatol & Venerol, Dept Dermatol & Venerol, DE-37075 Gottingen, Germany.
C3 University of Gottingen
RP Zutt, M (通讯作者)，Univ Gottingen, Abt Dermatol & Venerol, Dept Dermatol & Venerol, Von Siebold Str 3, DE-37075 Gottingen, Germany.
EM mzutt@gwdg.de
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NR 11
TC 19
Z9 19
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-8665
J9 DERMATOLOGY
JI Dermatology
PY 2007
VL 214
IS 4
BP 319
EP 324
DI 10.1159/000100882
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 162CF
UT WOS:000246063700008
PM 17460403
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Norbury, K
   Kieswetter, K
AF Norbury, Kenneth
   Kieswetter, Kris
TI Vacuum-assisted closure therapy attenuates the inflammatory response in
   a porcine acute wound healing model
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID TUMOR-NECROSIS-FACTOR; VASCULAR-DISEASE; GROWTH-FACTORS; T-LYMPHOCYTES;
   CYTOKINES; MICE; EXPRESSION; REPAIR; TISSUE; IL-6
AB Porcine full-thickness wounds were treated with V.A.C.(R) Therapy (KCI, San Antonio, Tex) or moist wound dressing without negative pressure. V.A.C. Therapy related systemic effects included post-wound reduction in the number of peripheral blood monocytes and neutrophils during the inflammatory phase of wound healing, as well as reduced serum levels of the pro-inflammatory cytokines IFN-gamma and IL-6. Local effects included reduced concentrations of IL-8, TGF-beta 1, and TNF-alpha in wound fluid following V.A.C. Therapy. Collectively, these responses suggest that V.A.C. Therapy may attenuate the pro-inflammatory response following cutaneous wounding.
C1 Kinet Concepts Inc, San Antonio, TX 78249 USA.
RP Norbury, K (通讯作者)，Kinet Concepts Inc, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM norburyk@kci1.com
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NR 58
TC 26
Z9 33
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2007
VL 19
IS 4
BP 97
EP 106
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 164RW
UT WOS:000246252700005
PM 26110258
DA 2026-07-24
ER
PT J
AU Baisch, A
   Hörmann, K
   Goessler, UR
   Sauter, A
   Riedel, F
AF Baisch, A.
   Hormann, K.
   Goessler, U. R.
   Sauter, A.
   Riedel, F.
TI Vacuum-assisted closure of nonhealing wounds in head and neck
   reconstructive surgery
SO HNO
LA English
DT Article
DE vacuum sealing; vacuum therapy; wound treatment; topical negative
   pressure
ID PRESSURE; FLAP
AB Chronic wounds are characterized by slow or nonexistent wound healing. Usually their treatment is expensive. Therefore new concepts in management are of interest in order to reduce treatment time and costs. One option is vacuum sealing. The concept of topical negative pressure is not new, and many chronic nonhealing wounds could be closed successfully with the help of vacuum sealing. Until now, there has been no documented case of vacuum sealing in head and neck reconstructive surgery. Our case shows the effectiveness of a vacuum-assisted device in successful closure of a chronic nonhealing wound in this region.
C1 Univ Hals Nasen Ohren Klin, D-68135 Mannheim, Germany.
C3 Ruprecht Karls University Heidelberg
RP Riedel, F (通讯作者)，Univ Hals Nasen Ohren Klin, Theodor Kutzer Ufer, D-68135 Mannheim, Germany.
EM frank.riedel@hno.ma.uni-heidelberg.de
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NR 24
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0017-6192
EI 1433-0458
J9 HNO
JI HNO
PD MAY
PY 2007
VL 55
IS 5
BP 392
EP +
DI 10.1007/s00106-006-1404-9
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 166CI
UT WOS:000246354400011
PM 16614842
DA 2026-07-24
ER
PT J
AU Guzzo, J
   Bluman, EM
AF Guzzo, John
   Bluman, Eric M.
TI Technique tip: Easing subatmospheric wound dressing application and
   increasing sponge conformity
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PRESSURE THERAPY; FOOT
C1 Madigan Army Med Ctr, Tacoma, WA 98431 USA.
C3 Madigan Army Medical Center
RP Bluman, EM (通讯作者)，Madigan Army Med Ctr, 9040 A Fitzsimmons Dr, Tacoma, WA 98431 USA.
EM emb43@cornell.edu
RI Bluman, Eric M/K-5849-2019
OI Bluman, Eric M/0000-0002-3848-1677
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Banwell P E, 2005, J Wound Care, V14, P445
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Jones SM, 2004, PLAST RECONSTR SURG, V114, P815, DOI 10.1097/01.PRS.0000136530.06899.92
   Kamolz LP, 2004, BURNS, V30, P253, DOI 10.1016/j.burns.2003.12.003
   Mendonca DA, 2005, FOOT ANKLE INT, V26, P761, DOI 10.1177/107110070502600915
NR 6
TC 2
Z9 2
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD MAY
PY 2007
VL 28
IS 5
BP 638
EP 639
DI 10.3113/FAI.2007.0638
PG 2
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 166UH
UT WOS:000246405400021
PM 17559777
DA 2026-07-24
ER
PT J
AU Bonnet, F
   Pavy, B
   Beaudoin, S
   Dubousset, J
   Mitrofanoff, M
AF Bonnet, Florent
   Pavy, Bernard
   Beaudoin, Sylvie
   Dubousset, Jean
   Mitrofanoff, Marc
TI Treatment of a large defect of the chest wall in a child using a
   negative pressure wound dressing
SO SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND
   SURGERY
LA English
DT Article
DE chest reconstruction; vacuum-assisted closure (R); negative pressure
   wound therapy; prosthesis exposure
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUNDS; SYSTEM
AB Vacuum-assisted closure(VAC (R)) is a simple wound healing tool in plastic surgery. We report a large thoracic defect in a child, in which the VAC (R) was used to cover an exposed polytetrafluoroethylene prosthesis. The VAC (R) saved the prosthesis and induced complete granulation of the wound, which healed completely in five weeks.
C1 Hop St Vincent de Paul, Serv Chirurg Pediat, Unite Chirurg Plast, Dept Plast & Reconstruct Surg,FR 75674, F-75674 Paris 14, France.
   Hop St Vincent de Paul, Dept Paediat Surg, F-75674 Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Cochin - APHP; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Cochin - APHP
RP Bonnet, F (通讯作者)，Hop St Vincent de Paul, Serv Chirurg Pediat, Unite Chirurg Plast, Dept Plast & Reconstruct Surg,FR 75674, 74 Ave Denfert Rochereau, F-75674 Paris 14, France.
EM florentbonnet@hotmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P E, 1999, J Wound Care, V8, P79
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Harlan JW, 2002, PLAST RECONSTR SURG, V109, P710, DOI 10.1097/00006534-200202000-00045
   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Shilt JS, 2004, J PEDIATR ORTHOPED, V24, P482, DOI 10.1097/01241398-200409000-00006
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
NR 10
TC 7
Z9 7
U1 0
U2 1
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 0284-4311
J9 SCAND J PLAST RECONS
JI Scand. J. Plast. Reconstr. Surg. Hand Surg.
PY 2007
VL 41
IS 3
BP 143
EP 145
DI 10.1080/02844310600699499
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 171FU
UT WOS:000246721500009
PM 17486521
DA 2026-07-24
ER
PT J
AU Fleck, T
   Moidl, R
   Grimm, M
   Wolner, E
   Zuckermann, A
AF Fleck, T.
   Moidl, R.
   Grimm, M.
   Wolner, E.
   Zuckermann, A.
TI Vacuum assisted closure therapy for the treatment of sternal wound
   infections after heart transplantation: Preliminary results
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE VAC therapy; heart transplantation; immunosuppression; adequate
   inflammation response
ID DELAYED CLOSURE; COMPLICATIONS; MEDIASTINITIS; BRIDGE
AB Sternal wound infection after heart transplantation is a feared and potentially life threatening complication with reported incidences between 2.5% and 3.6%. However, optimal therapy of sternal wound infections in heart transplant recipients remains a matter of controversy, particularly the effect of immunosuppression in those patients is still unclear. We examined 5 heart transplanted patients (4 men and 1 woman with a median age of 46 +/- 21.4 years (ranging from 14 to 59 years) in terms of inflammation and treatment response during VAC therapy. Infection begin was median 18.2 days (+/- 10 days, ranging from 5 to 28 days) after transplantation. VAC therapy lasted on average 12.2 +/- 2 days, ranging from 10 to 19 days. A median of 3 changes (range from 3 to 5) were necessary until the definitive closure. We examined C-reactive protein, leucocyte count and fibrinogen 2 days pre VAC, during VAC treatment and 2 days after definitive closure. All five patients showed an increase of leucocytes at every VAC change. Furthermore, we saw an adequate reaction to the VAC in terms of granulation tissue growth and resolution of infection. Transplanted patients had an increase of leucocytes at every VAC change. Furthermore all patients showed an adequate response of VAC treatment in terms of granulation tissue in growth and infection decline. Therefore a reduction of immunosuppressive therapy is not necessary, which in turn would increase the risk of rejection.
C1 Med Univ Vienna, Dept Cardiothorac Surg, Vienna, Austria.
C3 Medical University of Vienna
RP Fleck, T (通讯作者)，Univ Vienna, Chirurg Klin, Abt Herz Thoraxchirurg, AKH Vienna, Leitstelle 20A,Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM t9204604@hotmail.com
OI Zuckermann, Andreas/0000-0002-8054-8150
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ASCHERMAN JA, 1995, J THORAC CARDIOV SUR, V110, P1030, DOI 10.1016/S0022-5223(05)80171-0
   BALDWIN RT, 1992, J HEART LUNG TRANSPL, V11, P545
   Carrier M, 2001, ANN THORAC SURG, V72, P719, DOI 10.1016/S0003-4975(01)02824-7
   Fleck TM, 2004, ANN PLAS SURG, V52, P310, DOI 10.1097/01.sap.0000105524.75597.e0
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Lindsey JT, 2002, PLAST RECONSTR SURG, V109, P1882, DOI 10.1097/00006534-200205000-00015
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 12
TC 4
Z9 5
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2007
VL 132
IS 2
BP 138
EP 141
DI 10.1055/s-2007-960650
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 171UO
UT WOS:000246761100009
PM 17516320
DA 2026-07-24
ER
PT J
AU McCord, SS
   Naik-Mathurian, BJ
   Murphy, KM
   McLane, KM
   Gay, AN
   Basu, CB
   Downey, CR
   Hollier, LH
   Olutoye, OO
AF McCord, Shannon S.
   Naik-Mathurian, Bindi J.
   Murphy, Kathy M.
   McLane, Kathy M.
   Gay, Andre N.
   Basu, C. Bob
   Downey, Cara R.
   Hollier, Larry H.
   Olutoye, Oluyinka O.
TI Negative pressure therapy is effective to manage a variety of wounds in
   infants and children
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUNDS
AB Negative pressure therapy (NPT) has been accepted as a valuable adjunct for wound closure in adults; however, reports on its effectiveness in young children and infants, including neonates, are limited. A retrospective chart review was conducted on children treated with NPT at a single institution between January 2003 and December 2005. Wound volumetric measurements were calculated at the start and end of therapy. Sixty-eight patients with 82 wounds were identified. The mean age was 8.5 years (range 7 days-18 years). Twenty patients (29%) were 2 years of age or younger, including eight neonates. Wound types included: pressure ulcers (n=13), extremity wounds (n=18), dehisced surgical wounds (n=19), open sternal wounds (n=10), wounds with fistulas (n=3), and complex abdominal wall defects (n=6). Low suction pressures (< 100mmHg) were generally used in children younger than 4 years of age. Following NPT, 93% of wounds decreased in volume. The average wound volume decrease was 80% (p < 0.01, n=56). NPT can be effectively used to manage a variety of wounds in children and neonates. No major complications were identified in our retrospective review. Prospective studies are required to better refine the use of this technology in children.
C1 Baylor Coll Med, Div Pediat Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   Texas Childrens Hosp, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   Medical Hospital
RP Olutoye, OO (通讯作者)，Baylor Coll Med, Div Pediat Surg, Michael E DeBakey Dept Surg, 6621 Fannin St,CC650-00, Houston, TX 77030 USA.
EM oolutoye@bcm.tmc.edu
RI /AAJ-3357-2021
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
   Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bookout Kimberly, 2004, J Wound Ostomy Continence Nurs, V31, P184
   Brown KM, 2001, ANN THORAC SURG, V72, P1409, DOI 10.1016/S0003-4975(01)02844-2
   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   Cowan KN, 2005, ANN THORAC SURG, V80, P2205, DOI 10.1016/j.athoracsur.2005.04.005
   Hockenberry M., 2005, WONGS ESSENTIALS PED
   *KCI, 2005, VAC THER CLIN GUID R
   Kilbride KE, 2006, J PEDIATR SURG, V41, P212, DOI 10.1016/j.jpedsurg.2005.10.003
   Krasner Diane L, 2002, Ostomy Wound Manage, V48, P38
   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Ramnarine IR, 2002, EUR J CARDIO-THORAC, V22, P1029, DOI 10.1016/S1010-7940(02)00562-6
   Shilt JS, 2004, J PEDIATR ORTHOPED, V24, P482, DOI 10.1097/01241398-200409000-00006
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
NR 17
TC 45
Z9 52
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2007
VL 15
IS 3
BP 296
EP 301
DI 10.1111/j.1524-475X.2007.00229.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 172IH
UT WOS:000246797000004
PM 17537115
DA 2026-07-24
ER
PT J
AU Guille, AE
   Tseng, LW
   Orsher, RJ
AF Guille, April E.
   Tseng, Laura W.
   Orsher, Robert J.
TI Use of vacuum-assisted closure for management of a large skin wound in a
   cat
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID NEGATIVE-PRESSURE; THERAPY; DEVICE; TRIAL
AB Case Description-A 9-month-old domestic shorthair cat was evaluated after being struck by a car.
   Clinical Findings-The cat had a fractured tibia and avulsion of the tail base. Motor and deep pain sensation were absent from the tail. The fractured tibia was repaired 2 days after the trauma. On the third day, the cat developed tachypnea, dyspnea, high serum urea nitrogen and total bilirubin concentrations, epistaxis, persistent hypotension, and oliguria. The cat recovered with supportive care but developed extensive necrosis of the skin on the dorsum by 9 days after the initial trauma.
   Treatment and Outcome-The skin was debrided from the caudal portion of the scapula to the anus and down each pelvic limb to the level of the distal portion of the femur. The tail was amputated. Wet-to-dry bandages were applied to the wound for 3 days. Approximately 50% of the wound underwent delayed primary closure, and the remainder was managed with vacuum-assisted closure. A healthy granulation bed was quickly established. Vacuum-assisted closure was also applied after graft application. Graft acceptance was 100%, and use of the vacuum-assisted closure bandage was not associated with the complications associated with the traditional bandage.
   Clinical Relevance-Vacuum-assisted closure is a useful, easily applicable technique for open and grafted wounds, even when wounds are in challenging anatomic locations.
C1 Vet Specialty & Emergency Ctr, Langhorne, PA 19047 USA.
RP Guille, AE (通讯作者)，Vet Specialty & Emergency Ctr, 1900 W Old Lincoln Hwy, Langhorne, PA 19047 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Carson Stanley N, 2004, Ostomy Wound Manage, V50, P52
   Huang S, 1998, MOL BIOL CELL, V9, P3179, DOI 10.1091/mbc.9.11.3179
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P249, DOI 10.1097/00003086-198901000-00038
   Joseph E, 2000, WOUNDS, V12, P60
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   Marathe US, 2004, LARYNGOSCOPE, V114, P961, DOI 10.1097/00005537-200406000-00001
   Meara JG, 1999, ANN PLAS SURG, V42, P589, DOI 10.1097/00000637-199906000-00002
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Muir W, 2006, J VET EMERG CRIT CAR, V16, P253, DOI 10.1111/j.1476-4431.2006.00185.x
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Quah H M, 2004, J Tissue Viability, V14, P59
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Schaffzin DM, 2004, DIS COLON RECTUM, V47, P1745, DOI 10.1007/s10350-004-0633-9
   Scholl L, 2004, J CARDIAC SURG, V19, P453, DOI 10.1111/j.0886-0440.2004.05002.x
   SWAIM SF, 2003, TXB SMALL ANIMAL SUR, P321
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   WALTON RS, 2002, VET ICU BOOK, P785
   Welch RD, 1999, VET CLIN N AM-SMALL, V29, P1187, DOI 10.1016/S0195-5616(99)50109-5
NR 20
TC 38
Z9 41
U1 0
U2 11
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
EI 1943-569X
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD JUN 1
PY 2007
VL 230
IS 11
BP 1669
EP 1673
DI 10.2460/javma.230.11.1669
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 172OC
UT WOS:000246812600045
PM 17542735
OA Bronze
DA 2026-07-24
ER
PT J
AU Bendewald, FR
   Cima, RR
   Metcalf, DR
   Hassan, I
AF Bendewald, Frank R.
   Cima, Robert R.
   Metcalf, Dan R.
   Hassan, Imran
TI Using negative pressure wound therapy following surgery for complex
   pilonidal disease: A case series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE pilonidal sinus; vacuum-assisted closure; negative pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; SINUS-DISEASE; Z-PLASTY;
   FLAP; MORBIDITY
AB Complex pilonidal disease, an uncommon manifestation of an anorectal condition, is characterized by chronic or recurrent abscesses with extensive, branching sinus tracts. Definitive treatment requires wide excision of all involved tissue followed by secondary intention healing or reconstructive surgery. All treatment options have unique advantages and disadvantages. Following recent reports that negative pressure wound therapy after surgery for complex pilonidal disease may be a useful alternative to moist saline dressing treatments, five patients (three men and two women, median age 21 years [range: 16 to 63 years]) with complex pilonidal disease (symptom duration range 6 months to 30 years) were treated on an outpatient basis. Following wide excision under general anesthesia, a portable negative pressure wound therapy device was applied. Mean wound defect size after excision was 11 cm x 4 cm x 5 cm, or 205 cm(3) (range 90 cm(3) to 410 cm(3)). Negative pressure wound therapy was used for an average of 6 weeks (range 4 to 9 weeks) and mean time to complete epithelialization was 12 weeks (range 9 to 22 weeks), including use of moist saline dressings post negative pressure wound therapy. Treatment was discontinued in one patient due to skin irritation. No other complications were observed. Long-term follow-up is required to assess the risk of recurrent pilonidal disease or wound failure following negative pressure wound therapy. Additional studies of negative pressure wound therapy in the management of pilonidal disease are warranted.
C1 Mayo Clin, Coll Med, Div Colon & Rectal Surg, Rochester, MN USA.
   Ferguson Clin, Dept Surg, Grand Rapids, MI USA.
   So Illinois Univ, Sch Med, Dept Surg, Springfield, IL 62794 USA.
C3 Mayo Clinic; Southern Illinois University System; Southern Illinois
   University
RP Cima, RR (通讯作者)，200 1st St SW, Rochester, MN 55905 USA.
EM Cima.Robert@mayo.edu
OI Hassan, Imran/0000-0002-5710-5191
CR ALHASSAN HK, 1990, ACTA CHIR SCAND, V156, P595
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   FUZUN M, 1994, DIS COLON RECTUM, V37, P1148, DOI 10.1007/BF02049819
   Joseph E, 2000, WOUNDS, V12, P60
   KARYDAKIS GE, 1992, AUST NZ J SURG, V62, P385, DOI 10.1111/j.1445-2197.1992.tb07208.x
   Kitchen PRB, 1996, BRIT J SURG, V83, P1452, DOI 10.1002/bjs.1800831040
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   MANSOORY A, 1982, SURG GYNECOL OBSTET, V155, P409
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nivatvongs S., 2004, Mayo Clinic Gastrointestinal Surgery, P589
   PEREZGURRI JA, 1984, DIS COLON RECTUM, V27, P262, DOI 10.1007/BF02553803
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   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Rosen W, 1996, ANN PLAS SURG, V37, P293, DOI 10.1097/00000637-199609000-00010
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Schoeller T, 1997, SURGERY, V121, P258, DOI 10.1016/S0039-6060(97)90354-8
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   Sondenaa K, 1996, EUR J SURG, V162, P237
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NR 29
TC 22
Z9 24
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAY
PY 2007
VL 53
IS 5
BP 40
EP 46
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 173UZ
UT WOS:000246899300005
PM 17551174
DA 2026-07-24
ER
PT J
AU Lafortune, M
   Fleming, GJ
   Wheeler, JL
   Göbel, T
   Mozingo, DW
AF Lafortune, Maud
   Fleming, Gregory J.
   Wheeler, Jason L.
   Gobel, Thomas
   Mozingo, David W.
TI Wound management in a juvenile tiger (Panthera tigris) with
   vacuum-assisted closure (VAC therapy)
SO JOURNAL OF ZOO AND WILDLIFE MEDICINE
LA English
DT Article
DE vacuum-assisted closure; tiger; Panthera tigris; wound management
ID THORACODORSAL; FLAPS; CATS
AB A 6-wk-old tiger (Panthera tigris) was evaluated for severe skin lacerations from an adult tiger attack. A caudal superficial epigastric skin flap was Surgically placed to cover a defect that could not be closed over the hind limb; however, the skin flap did not adhere well to the granulation tissue over a period of 1 mo. The granulation bed matured and deteriorated. A subatmospheric pressure technique (vacuum-assisted closure, V.A.C.(R) Therapy (TM), Kinetic Concepts Inc., Sail Antonio, Texas 78219, USA) was utilized, and flap adherence occurred after 4 wk. This technique should be considered when dealing with severe or chronic wounds in tractable animals.
C1 Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA.
   Univ Florida, Coll Med, Dept Surg, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Lafortune, M (通讯作者)，Houston Zoo Inc, 1513 N MacGregor, Houston, TX 77030 USA.
EM mlafortune@houstonzoo.org
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   HEDLUND CS, 1997, SMALL ANIMAL SURG, P91
   *INT SPEC INV SYST, 1999, PANTHERA TIGRIS 8 DA
   Joseph E, 2000, WOUNDS, V12, P60
   *KIN CONC INC, 2003, V A C THER CLIN GUID, P1
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 10
TC 17
Z9 21
U1 0
U2 5
PU AMER ASSOC ZOO VETERINARIANS
PI YULEE
PA 581705 WHITE OAK ROAD, YULEE, FL 32097 USA
SN 1042-7260
J9 J ZOO WILDLIFE MED
JI J. Zoo Wildl. Med.
PD JUN
PY 2007
VL 38
IS 2
BP 341
EP 344
DI 10.1638/1042-7260(2007)038[0341:WMIAJT]2.0.CO;2
PG 4
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 177AN
UT WOS:000247126100023
PM 17679522
DA 2026-07-24
ER
PT J
AU Holle, G
   Riedel, K
   von Gregory, H
   Gazyakan, E
   Raab, N
   Germann, G
AF Holle, G.
   Riedel, K.
   von Gregory, H.
   Gazyakan, E.
   Raab, N.
   Germann, G.
TI Vacuum-assisted closure therapy. Current status and basic research
SO UNFALLCHIRURG
LA German
DT Article
DE VAC therapy; wound treatment; mechanical cell stimulation; soft tissue
   defects; cellular effect
ID SUBATMOSPHERIC PRESSURE; WOUND THERAPY
AB The gap between the broad clinical use of vacuum-assisted closure therapy (VT) and knowledge of the physiological mechanisms leading to its effectiveness is great. The value of the technique and its future development are dependent on research into these mechanisms.
   A meta-analysis evaluating the results of basic research on the effectiveness of VT was carried out based on peer reviewed publications. This is considered in relation to other therapeutic approaches of basic research to wound healing (growth factors etc.). Our study includes a concise description of the scientific background to the mechanisms of cell stimulation using basic work on tissue expansion, bone, vessel and nerve distraction as well as in vitro cell stimulation. Evaluation of the scientific data on all known effects of VT was made based on the results from experimental animal studies, the results of randomized clinical studies, observations on clinical applications and case reports. Assessment of the studies was based on design and significance as well as the appraisal of our own clinical experience. Data involving cellular effects (proliferation, synthesis, wound healing), systemic effects (mediators, systemic inflammatory disease), extracellular effects (perfusion, edema, local wound environment, stabilization, barriers) and complex effects of VT (inflammation, matrix function, blood supply) were examined.
   Systematic analysis of the data allows scientifically interested surgeons rapid access to the theme, the first, to this extent, extensive overview of the current scientific situation as well as a comprehensive bibliography for all areas involving the theme of mechanical cell stimulation. The authors list major areas for future research and encourage the development of multicenter studies.
C1 Heidelberg Univ, Klin Plast & Handchirurg, Schwerbrandverletztenzentrum, Klin Hand Plast & Reconstrukt Chirurg, D-67071 Ludwigshafen, Germany.
C3 Ruprecht Karls University Heidelberg
RP Holle, G (通讯作者)，Heidelberg Univ, Klin Plast & Handchirurg, Schwerbrandverletztenzentrum, Klin Hand Plast & Reconstrukt Chirurg, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
EM plastic-holle@web.de
RI Gazyakan, Emre/HLW-5585-2023
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NR 30
TC 24
Z9 26
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD JUN
PY 2007
VL 110
IS 6
BP 490
EP 504
DI 10.1007/s00113-007-1267-x
PG 15
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 178YY
UT WOS:000247257500002
PM 17546436
DA 2026-07-24
ER
PT J
AU Mouës, CM
   van den Bemd, GJCM
   Heule, F
   Hovius, SER
AF Moues, C. M.
   van den Bemd, G. J. C. M.
   Heule, F.
   Hovius, S. E. R.
TI Comparing conventional gauze therapy to vacuum-assisted closure wound
   therapy:: A prospective randomised trial
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Wound-Healing-Society
CY 2003
CL SEATTLE, WA
SP Wound Healing Soc
DE clinical randomised trial; vacuum-assisted closure wound therapy;
   conventional wound therapy; assessment of wound healing
ID NEGATIVE-PRESSURE; CLINICAL-EXPERIENCE; SEALING-TECHNIQUE; SYSTEM;
   INFECTIONS; MANAGEMENT; DRESSINGS; ULCERS
AB Background: Vacuum-assisted closure wound therapy (vacuum therapy) has been used in our department since 1997 as a tool. to bridge the period between debridement and definite surgical closure in full-thickness wounds. We performed a prospective randomised ctinicaL trial to compare the efficacy of vacuum therapy to conventional moist gauze therapy in this stage of wound treatment.
   Methods: Treatment efficacy was assessed by semi-quantitative scoring of the wound conditions (signs of rubor, calor, exudate and fibrinous slough) and by wound surface area measurements. Tissue biopsies were performed to quantify the bacterial. load. Besides this, the duration until 'ready for surgical therapy' and complications encountered during therapy and postoperatively were recorded.
   Results: Fifty-four patients were included (vacuum n = 29, conventional n = 25). With vacuum therapy, healthier wound conditions were observed. Furthermore, a tendency towards a shorter duration of therapy was found, which was most prominent in late-treated wounds. In addition, the wound surface area reduced significantly faster with vacuum therapy. Surprisingly, these results were obtained without a decrease in the number of bacteria colonising the wound. Complications were minor, except for one case of septicaemia and one case of increased tissue necrosis, which compelled us to stop vacuum therapy. For the treatment of full-thickness wounds, vacuum therapy has proven to be a valid wound heating modality. (c) 2006 The British Association of Plastic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 Erasmus Univ, Med Ctr, Dept Plast & Reconstruct Surg, NL-3000 DR Rotterdam, Netherlands.
   Erasmus Univ, Med Ctr, Dept Dermatol, NL-3000 DR Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC
RP Mouës, CM (通讯作者)，Erasmus Univ, Med Ctr, Dept Plast & Reconstruct Surg, PO Box 1738, NL-3000 DR Rotterdam, Netherlands.
EM cmoues@hotmail.com
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NR 41
TC 138
Z9 169
U1 0
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PY 2007
VL 60
IS 6
BP 672
EP 681
DI 10.1016/j.bjps.2006.01.041
PG 10
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 179IC
UT WOS:000247282000017
PM 17485058
DA 2026-07-24
ER
PT J
AU Baharestani, MM
AF Baharestani, Mona Mylene
TI Use of negative pressure wound therapy in the treatment of neonatal and
   pediatric wounds: A restrospective examination of clinical outcomes
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE negative pressure wound therapy; pediatric wound care; vacuum-assisted
   closure
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; STERNAL WOUNDS; MANAGEMENT;
   RECONSTRUCTION; DRESSINGS; INJURIES; PATIENT; SYSTEM; STATE
AB The clinical effectiveness of negative pressure wound therapy for the management of acute and chronic wounds is well documented in the adult population but information regarding its use in the pediatric population is limited. A retrospective, descriptive study was conducted to examine the clinical outcomes of using negative pressure wound therapy in the treatment of pediatric wounds. The medical records of 24 consecutive pediatric patients receiving negative pressure wound therapy were reviewed. Demographic data, wound etiology, time to closure, closure method, duration of negative pressure wound therapy, complications, dressing change frequency, dressing type used, and pressure settings were analyzed. All categorical variables in the dataset were summarized using frequency (count and percentages) and all continuous variables were summarized using median (minimum, maximum). The 24 pediatric patients (mean age 8.5 years [range 14 days to 18 years old]) had 24 wounds - 12 (50%) were infected at baseline. Sixteen patients had hypoalbuminemia and six had exposed hardware and bone in their wounds. Twenty-two wounds reached full closure in a median time of 10 days (range 2 to 45) following negative pressure wound therapy and flap closure (11), split-thickness skin graft (three), secondary (four), and primary (four) closure. Pressures used in this population ranged from 50 to 125 mm Hg and most wounds were covered with reticulated polyurethane foam. One patient developed a fistula during the course of negative pressure wound therapy. When coupled with appropriate systemic antibiotics, surgical debridement, and medical and nutritional optimization, in this population negative pressure wound therapy resulted in rapid granulation tissue and 92% successful wound closure. Future neonatal and pediatric negative pressure wound therapy usage registries and prospective studies are needed to provide a strong evidence base from which treatment decisions can be made in the management of these challenging cases, especially pertaining to the safety and efficacy of pressure settings, dressings, and interposing contact layer selection.
C1 Schneider Childrens Hosp, Long Isl Jewish Med Ctr, New Hyde Pk, NY 11040 USA.
C3 Northwell Health; North Shore University Hospital; Steven & Alexandra
   Cohen Children's Medical Center of New York
RP Baharestani, MM (通讯作者)，Schneider Childrens Hosp, Long Isl Jewish Med Ctr, 270-05 76th Ave, New Hyde Pk, NY 11040 USA.
EM mbahares@nshs.edu
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NR 46
TC 27
Z9 33
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2007
VL 53
IS 6
BP 75
EP 85
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 180QY
UT WOS:000247381800008
PM 17586874
DA 2026-07-24
ER
PT J
AU Gerry, R
   Kwei, S
   Bayer, L
   Breuing, KH
AF Gerry, Ryan
   Kwei, Stephanie
   Bayer, Lauren
   Breuing, Karl H.
TI Silver-impregnated vacuum-assisted closure in the treatment of
   recalcitrant venous stasis ulcers
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Northeastern-Society-of-Plastic-Surgeons
CY NOV 30-DEC 03, 2006
CL Boston, MA
SP NE Soc Plastic Surg
DE venous stasis ulcer; wound healing; vacuum-assisted closure; silver
ID WOUND THERAPY; ACTIVE EFFLUX; RESISTANCE; DRESSINGS; PROLIFERATION;
   ANGIOGENESIS; FOUNDATION; STATE
AB Vacuum-assisted closure (VAC) has made a significant contribution to the treatment of acute and chronic wounds. Microdeformational forces from the VAC device accelerate granulation tissue formation when compared with moist saline dressing changes. We present 2 patients with multiple comorbid conditions and complex venous stasis ulcers that had persistent purulent drainage after conventional treatment modalities. Only after utilizing silver-impregnated VAC therapy (GranuFoam Silver), combining the antimicrobial benefits of silver with the advantages of VAC technology, were the wound beds adequately prepared for substantial split-thickness skin grafts. Based on these cases, the silver-impregnated VAC device may be a useful adjunct in wound bed preparation when standard therapies have failed to clear infected wounds. This may lead to improved healing rates and overall decreased wound burden in these complex patients.
C1 Brigham & Womens Hosp, Div Plast & Reconstruct Surg, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital
RP Kwei, S (通讯作者)，Harvard Univ, Div Plast Surg, 1580 Massachusetts Ave,Apt 8E, Cambridge, MA 02138 USA.
EM skwei@partners.org
CR AMBROSIO A, 2005, VAC GRANUFOAM SILVER
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   Seymour Coral, 2006, Br J Nurs, V15, P598
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NR 32
TC 27
Z9 34
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUL
PY 2007
VL 59
IS 1
BP 58
EP 62
DI 10.1097/01.sap.0000263420.70303.cc
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 182IX
UT WOS:000247499400020
PM 17589262
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Malmsjö, M
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjoe, Malin
   Ingemansson, Richard
TI Blood flow changes in normal and ischemic myocardium during topically
   applied negative pressure
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND-INFECTION; LONG-TERM SURVIVAL;
   PERISTERNAL THORACIC WALL; RISK-FACTORS; REVASCULARIZATION;
   MEDIASTINITIS; THERAPY; COMPLICATIONS; IMPACT
AB Background. Topical negative pressure (TNP) therapy has been adopted as a first-line treatment for wound healing. One of the mechanisms by which TNP improves healing is by stimulating blood flow to the wound edge. Among patients with ischemic heart disease, it is of great importance to improve the microvascular blood flow in the myocardium during episodes of ischemia to protect the myocardium from infarction. The present study was designed to elucidate the effect of TNP on microvascular blood flow in the myocardium.
   Methods. Six pigs underwent median sternotomy. The microvascular blood flow in the myocardium was recorded, before and after the application of TNP, by using laser Doppler velocimetry. Analyses were performed before left anterior descending artery ( LAD) occlusion ( normal myocardium), after 20 minutes of LAD occlusion ischemic myocardium), and after 20 minutes of reperfusion (reperfused myocardium).
   Results. TNP at -0 mm Hg increased microvascular blood flow in the normal myocardium from 14.7 +/- 3.9 perfusion units (PU) before to 25.8 +/- 6.1 PU after TNP application ( p < 0.05), in the ischemic myocardium from 7.2 +/- 1.5 PU before to 13.8 +/- 2.6 PU after TNP application ( p < 0.05), and in the reperfused myocardium from 10.8 +/- 2.0 PU before to 19.3 +/- 5.6 PU after TNP application ( p < 0.05).
   Conclusions. TNP increases the microvascular blood flow significantly in normal, ischemic, and reperfused myocardium and may provide a novel therapeutic tool in the treatment of ischemic myocardium.
C1 Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Ingemansson,
   Richard/0000-0001-7623-8953; Maljö, Malin/0000-0001-9849-9599
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 32
TC 27
Z9 39
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD AUG
PY 2007
VL 84
IS 2
BP 568
EP 573
DI 10.1016/j.athoracsur.2007.02.066
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 192HS
UT WOS:000248192400030
PM 17643636
DA 2026-07-24
ER
PT J
AU Andrabi, SIH
   Ahmad, J
AF Andrabi, Syed Imran Hussain
   Ahmad, Jawad
TI Negative pressure therapy for laparotomy wounds - A word of caution
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
AB Negative pressure wound therapy (NPWT) is being used for the management of laparotomy wounds. The device applies subatmospheric pressure to the open abdominal wounds. We suggest a modification in its application to prevent a leak from the bowel.
C1 Royal Victoria Hosp, Dept Surg, Belfast BT12 6BA, Antrim, North Ireland.
RP Andrabi, SIH (通讯作者)，73 Sicily Pk, Belfast BT10 0AN, Antrim, North Ireland.
EM imranandrabi@gmail.com
RI Indrabi, Dr Syed/AAX-4352-2021
CR Morykwas M J., 1997, J South Orthop Assoc, V6, P284
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
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NR 3
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1071-5754
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2007
VL 34
IS 4
BP 425
EP 427
DI 10.1097/01.WON.0000281660.99957.79
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 192HY
UT WOS:000248193100011
PM 17667090
DA 2026-07-24
ER
PT J
AU Liao, EC
   Breuing, KH
AF Liao, Eric C.
   Breuing, Karl H.
TI Breast mound salvage using vacuum-assisted closure device as bridge to
   reconstruction with inferolateral AlloDerm hammock
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE breast reconstruction; implant infection; hematoma; acellular dermal
   matrix; AlloDerm; vacuum-assisted closure device; VAC
ID WOUND THERAPY; INFECTIONS; IMPLANTS
C1 Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Breuing, KH (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM kbreuing@partners.org
OI Liao, Eric/0000-0001-6385-7448
CR Armstrong DG, 2004, WOUNDS, P9
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NR 18
TC 16
Z9 18
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD AUG
PY 2007
VL 59
IS 2
BP 218
EP 224
DI 10.1097/SAP.0b013e31802c148c
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 194SF
UT WOS:000248363400019
PM 17667419
DA 2026-07-24
ER
PT J
AU Swenne, CL
   Skytt, B
   Lindholm, C
   Carlsson, M
AF Swenne, C. L.
   Skytt, B.
   Lindholm, C.
   Carlsson, M.
TI Patients' experiences of mediastinitis after coronary artery bypass
   graft procedure
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE coronary artery by-pass; surgical wound infection; mediastinitis; vacuum
   assisted closure; psychology; quality of life
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; SURGERY; QUALITY; STRESS;
   INFECTION; CARE
AB Few studies have focussed on patients' experiences of and suffering due to mediastinitis following Coronary Artery by-pass Graft ( CABG). Mediastinitis creates a complex and invasive experience for the patient with prolonged hospitalisation, and would be expected to be a significant stressor. The aim of the present study was to capture patients' experiences of the medical and nursing care they received for mediastinitis following CABG. Content analysis revealed three themes with regard to how the patients coped with the stress and threats of mediastinitis and its treatment and how they thought it would influence their future life. A first theme centred on physical and psychological discomfort and impact on autonomy. The staff's medical knowledge and the quality of nursing care as well as the patients' understanding of the situation influenced their experience. A second theme was how patients dealt with perceived danger and stress. Coping strategies such as problem solving, information seeking, dissociation, distraction, minimisation and expression of emotion were used to handle the situations. The third theme comprised the patients' belief that the mediastinitis would not affect the outcome of the CABG procedure, even though their confidence in this was influenced by uncertainty about the rehabilitation process.
C1 Univ Uppsala Hosp, Dept Cardiothorac Surg, OTM Div, S-75185 Uppsala, Sweden.
   Dept Publ Hlth & Caring Sci, Uppsala Sci Pk, S-75185 Uppsala, Sweden.
   Uppsala Univ, Cty Council Gavleborg, Ctr Res & Dev, S-80188 Gavle, Sweden.
   Kristianstad Univ, Karolinska Inst, Dept Hlth Sci, Dept Surg Sci, S-29188 Kristianstad, Sweden.
C3 Uppsala University; Uppsala University Hospital; Uppsala University;
   Uppsala University; Kristianstad University; Karolinska Institutet
RP Swenne, CL (通讯作者)，Univ Uppsala Hosp, Dept Cardiothorac Surg, OTM Div, 40,Str, S-75185 Uppsala, Sweden.
EM christine.leo.swenne@akademiska.se
RI Skytt, Bernice/AGR-4086-2022
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NR 23
TC 6
Z9 7
U1 0
U2 4
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 1401-7431
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2007
VL 41
IS 4
BP 255
EP 264
DI 10.1080/14017430701283856
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 197SS
UT WOS:000248577400008
PM 17680514
DA 2026-07-24
ER
PT J
AU Bollero, D
   Carnino, R
   Risso, D
   Gangemi, EN
   Stella, M
AF Bollero, Daniele
   Carnino, Riccardo
   Risso, Daniela
   Gangemi, Ezio N.
   Stella, Maurizio
TI Acute complex traumas of the lower limbs: a modern reconstructive
   approach with negative pressure therapy
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EXPERIENCE; WOUND CLOSURE; MANAGEMENT;
   FRACTURES; INJURIES
AB Acute traumas of the lower limbs cause complex functional damage for the association of skin loss with exposed tendons, bones, and/or vessels, requiring a multidisciplinary approach. Once bone fixation and vascular repair have been carried out, the surgical treatment for skin damage is usually based on early coverage with conventional or microsurgical flaps. Negative pressure therapy can play a primary role in the management of the elderly or intensive care patients, where wounds are secondary to life-threatening problems. A total of 35 patients with 37 acute traumatic wounds of the lower limbs were treated with vacuum-assisted closure (VAC((R))) therapy for an average of 22 days (range 3-46 days). The sponge was applied the day after bone fixation, vascular repair, and surgical debridement of nonviable tissues, so as to obtain a better control of bleeding. After VAC treatment, all patients quickly developed healthy granulation tissue and a significant reduction in both extent and depth of wounds. Split-thickness skin grafts were used to cover granulation tissue in most of the cases (66%-24 cases), and then local flaps (13%-five cases) or direct sutures (8%-three cases). The wounds healed spontaneously without surgical management in four patients. One patient died during the treatment period for concomitant diseases. No relevant complications directly related to VAC((R)) therapy were observed other than one case of severe pain in an amputated stump. The average follow-up duration was 265 days (range 33-874 days). No further tegumentary reconstruction was required. VAC((R)) therapy may represent a valid alternative to immediate reconstruction in selected cases of acute complex traumas of the lower limb and allows for a stable functional result, using a minimally invasive approach.
C1 CTO Hosp, Dept Plast & Reconstruct Surg, Burn Ctr, Traumatol Ctr, I-10126 Turin, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino
RP Bollero, D (通讯作者)，CTO Hosp, Dept Plast & Reconstruct Surg, Burn Ctr, Traumatol Ctr, Via Zuretti 29, I-10126 Turin, Italy.
EM dbollero@hotmail.com
RI Stella, Maurizio/JGD-2010-2023; Gangemi, Ezio Nicola/M-8754-2019
OI Gangemi, Ezio Nicola/0000-0003-4381-7443; Carnino,
   Riccardo/0009-0005-2578-6999
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BISCHOFF M, 2003, EUR J PLAST SURG, V26, P186
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
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NR 15
TC 39
Z9 43
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2007
VL 15
IS 4
BP 589
EP 594
DI 10.1111/j.1524-475X.2007.00267.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 200HP
UT WOS:000248754800020
PM 17650104
DA 2026-07-24
ER
PT J
AU Labler, L
   Trentz, O
AF Labler, Ludwig
   Trentz, Otmar
TI The use of vacuum assisted closure (VAC™) in soft tissue injuries after
   high energy pelvic trauma
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE open fractures; pelvis; soft tissue defect; wound conditioning;
   vacuum-assisted closure
ID NEGATIVE-PRESSURE; DAMAGE CONTROL; WOUND THERAPY; MANAGEMENT; FRACTURES
AB Background Application of vacuum-assisted closure (VAC (TM)) in soft tissue defects after high-energy pelvic trauma is described as a retrospective study in a level one trauma center.
   Materials and methods Between 2002 and 2004, 13 patients were treated for severe soft tissue injuries in the pelvic region. All musculoskeletal injuries were treated with multiple irrigation and debridement procedures and broad-spectrum antibiotics. VAC (TM) was applied as a temporary coverage for defects and wound conditioning.
   Results The injuries included three patients with traumatic hemipelvectomies. Seven patients had pelvic ring fractures with five Morel-Lavallee lesions and two open pelviperineal trauma. One patient suffered from an open iliac crest fracture and a Morel-Lavallee lesion. Two patients sustained near complete pertrochanteric amputations of the lower limb. The average injury severity score was 34.1 +/- 1.4. The application of VAC (TM) started in average 3.8 +/- 0.4 days after trauma and was used for 15.5 +/- 1.8 days. The dressing changes were performed in average every 3 days. One patient (8%) with a traumatic hemipelvectomy died in the course of treatment due to septic complications.
   Conclusions High-energy trauma causing severe soft tissues injuries requires multiple operative debridements to prevent high morbidity and mortality rates. The application of VAC (TM) as temporary coverage of large tissue defects in pelvic regions supports wound conditioning and facilitates the definitive wound closure.
C1 Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Labler, L (通讯作者)，Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM ludwig.labler@usz.ch
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NR 42
TC 46
Z9 77
U1 0
U2 19
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD SEP
PY 2007
VL 392
IS 5
BP 601
EP 609
DI 10.1007/s00423-006-0090-0
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 201DH
UT WOS:000248811200014
PM 16983575
OA Green Accepted
DA 2026-07-24
ER
PT J
AU Loos, B
   Kopp, J
   Hohenberger, W
   Horch, RE
AF Loos, B.
   Kopp, J.
   Hohenberger, W.
   Horch, R. E.
TI Post-malignancy irradiation ulcers with exposed alloplastic materials
   can be salvaged with topical negative pressure therapy (TNP)
SO EJSO
LA English
DT Article; Proceedings Paper
CT Dreilaender Congress
CY 2004
CL Mainz, GERMANY
DE topical negative pressure; cancer; irradiated tissue; alloplastic
   material; oncologic surgery
ID VACUUM-ASSISTED CLOSURE; SURGICAL-TREATMENT; WOUND CONTROL; SURGERY;
   COMPLICATIONS; PENETRATION; EXPERIENCE; RADIATION; MUSCLE
AB Aim: The aim of this study was to salvage or to integrate exposed alloplastic meshes in post malignancy irradiated chronic wounds by using topical negative pressure (TNP) therapy together with staged debridement.
   Methods: Three patients with secondarily exposed alloplastic meshes in irradiated non-healing wounds were treated by serial debridement and repeated topical negative pressure therapy until clean and vital wounds were achieved, followed by ultimate plastic coverage by a myocutancous flap or split-thickness skin graft. The range of the follow-up period was from 18 to 36 months.
   Results: After staged serial debridement and repeated vacuum treatment periods wounds were preconditioned in an acceptable fashion for ultimate plastic coverage. After the treatment with a myocutaneous flap or split-thickness skin graft all three patients achieved long-term stable wounds with no alloplastic mesh complication within the follow-up period.
   Conclusion: Computer-controlled TNP therapy (vacuum-assisted closure therapy) together with staged debridement can help to induce granulation tissue formation in irradiated wounds and allows integration of alloplastic materials into regenerating wounds after ablative oncologic surgery. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Univ Erlangen Nurnberg, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
   Univ Erlangen Nurnberg, Dept Surg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Loos, B (通讯作者)，Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM bernd.loos@online.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
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NR 32
TC 12
Z9 13
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0748-7983
EI 1532-2157
J9 EJSO-EUR J SURG ONC
JI EJSO
PD SEP
PY 2007
VL 33
IS 7
BP 920
EP 925
DI 10.1016/j.ejso.2006.12.018
PG 6
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology; Surgery
GA 212PR
UT WOS:000249609800019
PM 17289332
DA 2026-07-24
ER
PT J
AU Stainier, A
   Tombal, B
   Di Gregorio, M
   Van Cauwenberghe, G
   Querton, M
   Fosseprez, P
   Lorge, F
AF Stainier, Annabelle
   Tombal, Bertrand
   Di Gregorio, Marcelo
   Van Cauwenberghe, Gilles
   Querton, Michael
   Fosseprez, Philippe
   Lorge, Francis
TI Fournier's gangrene on ischial pressure ulcer : use of vacuum-assisted
   closure and therapeutic strategy
SO PROGRES EN UROLOGIE
LA French
DT Article
DE Fournier's gangrene; vacuum-assisted closure; reconstruction
AB Vacuum-assisted closure (V.A.C.) was used in two paraplegic patients with Fournier's gangrene in a context of ischial pressure ulcer. This type of dressing facilitated preparation of reconstruction.
C1 UCL Mt Godinne, Serv Urol, Yvoir, Belgium.
   UCL St Luc, Serv Urol, Brussels, Belgium.
   UCL Mt Godinne, Serv Chirurg Plast, Yvoir, Belgium.
C3 Universite Catholique Louvain; Universite Catholique Louvain Hospital;
   Universite Catholique Louvain; Universite Catholique Louvain; Universite
   Catholique Louvain Hospital
RP Stainier, A (通讯作者)，Ave G Therasse 1, B-5530 Yvoir, Belgium.
EM Annabelle.Stainier@mont.ucl.ac.be
OI TOMBAL, Bertrand/0000-0002-0093-8408
CR Bickels J, 2005, CLIN ORTHOP RELAT R, P346, DOI 10.1097/01.blo.0000180450.21350.3e
   Cannistra C, 2003, PROG UROL, V13, P703
   Demaria RG, 2003, HEART SURG FORUM, V6, P434
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Tahmaz L, 2006, INT J UROL, V13, P960, DOI 10.1111/j.1442-2042.2006.01448.x
NR 5
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER MASSON, CORP OFF
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1166-7087
EI 2405-5131
J9 PROG UROL
JI Prog. Urol.
PD SEP
PY 2007
VL 17
IS 5
BP 1000
EP 1002
DI 10.1016/S1166-7087(07)92407-0
PG 3
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 215JJ
UT WOS:000249804300022
PM 17969807
DA 2026-07-24
ER
PT J
AU Ben-Amotz, R
   Lanz, OI
   Miller, JM
   Filipowicz, DE
   King, MD
AF Ben-Amotz, Ron
   Lanz, Otto I.
   Miller, Jonathan M.
   Filipowicz, Dean E.
   King, Michael D.
TI The use of vacuum-assisted closure therapy for the treatment of distal
   extremity wounds in 15 dogs
SO VETERINARY SURGERY
LA English
DT Article
ID NEGATIVE-PRESSURE; SKIN; MANAGEMENT; INJURIES; SOFT
AB Objective-To evaluate clinical outcome after vacuum-assisted closure (VAC) therapy in dogs with traumatic wounds located in the distal extremities and report our early experience with VAC.
   Study Design-Retrospective study.
   Animals-Dogs (n=15) with traumatic distal extremity wounds.
   Methods-Medical records (1999-2003) of dogs with traumatic injuries to the distal extremities managed by VAC were evaluated. Data included signalment, location of wound, time until surgical intervention, wound reconstruction methods, orthopedic procedures, outcome, complications associated with VAC, and length of hospitalization.
   Results-The mean number of days until reconstruction was 4.6 days (range, 2-7 days). Reconstructive surgery was successful in all cases. Mean hospitalization was 9.7 days (range, 6-16 days). Complications included dermatitis at the wound margin and loss of vacuum causing wound desiccation.
   Conclusion-VAC therapy can be used to achieve adequate management of traumatic distal extremity wounds. VAC provides an effective method of securing skin grafts over the wound bed.
   Clinical Relevance-VAC therapy can be used as an ancillary treatment for distal extremity wounds in dogs before surgical repair as well as a method for securing skin grafts to the wound bed. (C) Copyright 2007 by The American College of Veterinary Surgeons.
C1 Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA 24061 USA.
C3 Virginia Polytechnic Institute & State University
RP Ben-Amotz, R (通讯作者)，Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA 24061 USA.
EM ronba1@gmail.com
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NR 36
TC 49
Z9 52
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD OCT
PY 2007
VL 36
IS 7
BP 684
EP 690
DI 10.1111/j.1532-950X.2007.00321.x
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 215SK
UT WOS:000249829100011
PM 17894595
DA 2026-07-24
ER
PT J
AU Crumbley, DR
   Perciballi, JA
AF Crumbley, David R.
   Perciballi, John A.
TI Negative pressure wound therapy in a contaminated soft-issue wound
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FLUID
AB Today's high-energy weapons can inflict extensive damage to the human body, causing significant tissue, muscle, and bone loss. Contamination, soft tissue swelling, and massive tissue defects associated with injuries from high-energy weapons frequently require these wounds to heal by secondary intention or delayed primary closure. Successful management of the contaminated soft-tissue injury with significant tissue loss poses challenges for the healthcare provider as well as the patient. The following case study demonstrates use of Negative Pressure Wound Therapy (NPWT) in the treatment of a missile-caused contaminated soft-tissue wound and examines some of the issues and outcomes associated with managing this type of catastrophic wound.
C1 USN, Washington, DC 20350 USA.
C3 United States Department of Defense; United States Navy
RP Crumbley, DR (通讯作者)，Natl Naval Med Ctr, Surg Ward 5 E, 8901 Rockville Pike, Bethesda, MD 20889 USA.
EM david.r.crumbley@med.navy.mil
CR [Anonymous], ACUTE CHRONIC WOUNDS
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NR 29
TC 2
Z9 2
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2007
VL 34
IS 5
BP 507
EP 512
DI 10.1097/01.WON.0000290729.93075.1c
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 215YE
UT WOS:000249844100011
PM 17876212
DA 2026-07-24
ER
PT J
AU Horn, PL
   Ruth, B
   Kean, JR
AF Horn, Pamela Lee
   Ruth, Brenda
   Kean, John R.
TI Use of wound VAC therapy in pediatric patients with infected spinal
   wounds - A retrospective review
SO ORTHOPAEDIC NURSING
LA English
DT Article
ID FUSION; INSTRUMENTATION; MANAGEMENT; CLOSURE
AB BACKGROUND: Deep wound infection in patients that have had a posterior spinal fusion for scoliosis is a major complication in pediatric spine surgery.
   PURPOSE: To explore characteristics of pediatric patients who had a posterior spinal fusion with segmental spinal instrumentation and bone graft and subsequently developed deep spinal wound infections that were treated with wound vacuum-assisted closure (V.A.C.) therapy
   METHOD: Retrospective Chart Review. Characteristics of patients' age, gender, comorbid illnesses, identified bacteria, antibiotics, time on V.A.C. device, infection recurrence, any instrumentation removal, and additional surgical intervention was collected.
   FINDINGS: There were 249 patients who had spinal fusions from December 2002 through January 2006, and 11 developed an infection after their spinal fusion and had the use of the V.A.C. device. Those who developed infection within 1 year of their fusion had instrument retention. Wound closure occurred in all cases that used V.A.C. therapy.
C1 Columbus Childrens Hosp, Dept Orthopaed, Clin Serv Care Coordinat, Columbus, OH USA.
C3 University System of Ohio; Ohio State University; Nationwide Childrens
   Hospital
RP Horn, PL (通讯作者)，Columbus Childrens Hosp, Dept Orthopaed, Clin Serv Care Coordinat, Columbus, OH USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BEINER JM, 2003, NEUROSURGERY FOCUS
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   MASSIE JB, 1992, CLIN ORTHOP RELAT R, P99
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   Wimmer C, 1996, J SPINAL DISORD, V9, P505
   YUANINNES MJ, 2001, SPINE
NR 10
TC 14
Z9 17
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0744-6020
J9 ORTHOP NURS
JI Orthop. Nurs.
PD SEP-OCT
PY 2007
VL 26
IS 5
BP 317
EP 322
DI 10.1097/01.NOR.0000295960.94450.69
PG 6
WC Nursing; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Orthopedics
GA 216VM
UT WOS:000249907100008
PM 17921893
DA 2026-07-24
ER
PT J
AU Kiyokawa, K
   Takahashi, N
   Rikimaru, H
   Yamauchi, T
   Inoue, Y
AF Kiyokawa, Kensuke
   Takahashi, Nagahiro
   Rikimaru, Hideaki
   Yamauchi, Toshihiko
   Inoue, Yojiro
TI New continuous negative-pressure and irrigation treatment for infected
   wounds and intractable ulcers
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Background: Continuous irrigation and the vacuum-assisted closure system are effective methods for the treatment of infected wounds and intractable ulcers. The objective of this study was to simultaneously use both of the above methods as a new approach for obtaining more satisfactory, accelerated wound healing.
   Methods: After debridement of the wound, indwelling irrigation and aspiration tubes are placed in the wounds that have been sutured closed. With open wounds, a sponge with the same shape as the wound is placed directly onto the wound surface, and after the two tubes are inserted in the sponge, the wound is covered with film dressing to make the wound completely airtight. A bottle of physiologic saline solution is then attached to the irrigation tube, and a continuous aspirator (Mera Sacume) is attached to the aspiration tube. The bottle of physiologic saline solution is placed at the same height as the wound, and with a pressure gradient between the two of 0, continuous aspiration is applied.
   Results: All nine cases treated as closed air cavity wounds with this method healed after 2 to 3 weeks. In eight cases of open wound, recurrence of infection was observed in only one case.
   Conclusions: The two treatments of continuous irrigation and negative pressure were observed to have an additive and synergistic effect for earlier wound healing. Furthermore, the present method can dramatically reduce the number of dressing changes required, patient pain, psychological stress, and treatment cost.
C1 Kurume Univ, Sch Med, Dept Plast & Reconstruct Surg, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University
RP Kiyokawa, K (通讯作者)，Kurume Univ, Sch Med, Dept Plast & Reconstruct Surg, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM prsmf@med.kurume-u.ac.jp
RI Kiyokawa, Kensuke/Q-5559-2017
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   CLAWSON DK, 1973, CLIN ORTHOP RELAT R, P88
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   Tachi M, 2004, ANN PLAS SURG, V53, P338, DOI 10.1097/01.sap.0000129234.84192.d4
NR 14
TC 39
Z9 57
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2007
VL 120
IS 5
BP 1257
EP 1265
DI 10.1097/01.prs.0000279332.27374.69
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 217VZ
UT WOS:000249976700019
PM 17898598
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Ingemansson, R
   Sjögren, J
AF Malmsjo, Malin
   Ingemansson, Richard
   Sjogren, Johan
TI Mechanisms governing the effects of vacuum-assisted closure in cardiac
   surgery
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID TOPICAL NEGATIVE-PRESSURE; STERNAL WOUND INFECTIONS; SUBATMOSPHERIC
   PRESSURE; HYPERBARIC-OXYGEN; SHEAR-STRESS; BLOOD-FLOW; THERAPY; DEEP;
   MEDIASTINITIS; RECRUITMENT
AB Vacuum-assisted closure has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome achieved with its use. Scientific evidence regarding the mechanisms by which vacuum-assisted closure promotes wound healing has started to emerge, although knowledge regarding the effects on heart and lung function is still limited. The organs in the mediastinum are hemodynamically crucial, and in patients with poststernotomy mediastinitis, vulnerable bypass grafts and reduced cardiac function must be taken into consideration during vacuum-assisted closure therapy. This article provides an overview of the effects of vacuum-assisted closure on heart and lung function and summarizes the current knowledge on the mechanisms by which vacuum-assisted closure therapy promotes wound healing.
C1 Univ Lund Hosp, Dept Med, SE-22184 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Surg, SE-22184 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，Univ Lund Hosp, Dept Med, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Sjögren, Johan/AAZ-6448-2021
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953
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NR 73
TC 35
Z9 36
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2007
VL 120
IS 5
BP 1266
EP 1275
DI 10.1097/01.prs.0000279326.84535.2d
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 217VZ
UT WOS:000249976700020
PM 17898599
DA 2026-07-24
ER
PT J
AU Frykberg, RG
   Williams, DV
AF Frykberg, Robert G.
   Williams, David V.
TI Negative-pressure wound therapy and diabetic foot amputations - A
   retrospective study of payer claims data
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article; Proceedings Paper
CT 11th Annual International Meeting of the
   International-Society-of-Pharmacoeconomics-and-Outcomes-Research
CY MAY 20-24, 2006
CL Philadelphia, PA
SP Int Soc Pharmacoecon & Outcomes Res
ID LOWER-EXTREMITY AMPUTATION; VACUUM-ASSISTED CLOSURE; LOWER-LIMB
   AMPUTATION; HEALTH-CARE; FOLLOW-UP; ULCERS; POPULATION; PREVENTION;
   COST; ULCERATION
AB Background: This study was undertaken to assess the benefits of negative-pressure wound therapy (NPWT) versus traditional wound therapies in reducing the incidence of lower-extremity amputations in patients with diabetic fool: ulcers.
   Methods: Administrative claims data for patients with diabetic foot ulcers from commercial payers (n = 3,524) and Medicare (n = 12,795) were retrospectively analyzed. Patients were divided into NPWT and control/traditional therapy groups on the basis of administrative codes. Risk-adjustment procedures were then performed to match patient risk categories (through total treatment costs) and wound severities (through debridement depth).
   Results: The incidence of amputations in the NPWT groups was lower than that in the control groups. For the cost-based risk-adjustment analysis, amputation incidences with NPWT versus traditional therapy were 35% lower in the Medicare sample (10.8% versus 16.6%; P = .0077) and 34% lower in the commercial payer sample (14.1 % versus 21.4%; P = .0951). Whereas overall amputation rates increased progressively with increasing wound debridement depth in both control groups, the same increasing trend did not occur in the NPWT groups.
   Conclusions: Patients with diabetic foot ulcers in the Medicare sample treated with NPWT had a lower incidence of amputations than those undergoing traditional wound therapy; this finding was evident in wounds of varying depth in both populations studied.
C1 Carl T Hayden Vet Adm Med Ctr, Podiatry Sect, Phoenix, AZ 85012 USA.
   Milliman Inc, Windsor, CT USA.
RP Frykberg, RG (通讯作者)，Carl T Hayden Vet Adm Med Ctr, Podiatry Sect, 650 E Indian Sch Rd, Phoenix, AZ 85012 USA.
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NR 40
TC 26
Z9 30
U1 0
U2 13
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD SEP-OCT
PY 2007
VL 97
IS 5
BP 351
EP 359
DI 10.7547/0970351
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics
GA 219KD
UT WOS:000250082600001
PM 17901338
DA 2026-07-24
ER
PT J
AU Ferdinando, E
   Guerin, L
   Jervis, AO
   Obidigbo, H
AF Ferdinando, Edward
   Guerin, Laura
   Jervis, Aluko O.
   Obidigbo, Hlenrietta
TI Negative-pressure wound therapy and external fixation for infection and
   hematoma after hallux abducto valgus surgery
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID PATIENT; CLOSURE
AB Hematoma refers to the collection or extravasation of blood, usually clotted, in a closed tissue space. It is caused by leakage from local vessels damaged by blunt trauma, local injury, or surgical dissection. In the postoperative phase, a hematoma often results in edema, pain, wound dehiscence, infection, and scarring of the surgical wound. We describe a 44-year-old woman who developed severe complications, including hematoma, abscess, failure of internal fixation, and loss of soft-tissue structures, after hallux abducto valgus surgery. Hospitalization was required for infection control, soft-tissue coverage through negative-pressure wound therapy, and first metatarsophalangeal joint stabilization through external fixation. Early recognition of the signs of infection and hematoma can help decrease the incidence of postoperative complications.
C1 Staten Isl Univ Hosp, Podiatr Residency Program, Dept Surg, Staten Isl, NY USA.
C3 Northwell Health
RP Guerin, L (通讯作者)，970 Bard Ave, Staten Isl, NY 10305 USA.
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
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NR 16
TC 0
Z9 1
U1 0
U2 1
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD SEP-OCT
PY 2007
VL 97
IS 5
BP 410
EP 414
DI 10.7547/0970410
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 219KD
UT WOS:000250082600012
PM 17901348
DA 2026-07-24
ER
PT J
AU Adkesson, MJ
   Travis, EK
   Weber, MA
   Kirby, JP
   Junge, RE
AF Adkesson, Michael J.
   Travis, Erika K.
   Weber, Martha A.
   Kirby, John P.
   Junge, Randall E.
TI Vacuum-assisted closure for treatment of a deep shell abscess and
   osteomyelitis in a tortoise
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID PRESSURE WOUND THERAPY; BLOOD-FLOW; MANAGEMENT; EXPERIENCE
AB Case Description-A female Aldabra tortoise (Geochelone gigantea) was evaluated because of focal necrosis of the carapace.
   Clinical Findings-Debridement revealed a 14.5 X 11.5-cm area of shell necrosis, deep abscess formation, and osteomyelitis involving bacterial (Klebsiella pneumoniae, Staphylococcus aureus, and Pseudomonas spp) and fungal pathogens.
   Treatment and Outcome-Following extensive debridement, vacuum-assisted closure incorporating silver-impregnated bandaging materials was used. The wound was considered healed after 55 days, at which time a layer of epidermal tissue with progressing keratinization was present, with smooth underlying ossification. Keratinization with normal pigmentation continued over the next 67 days.
   Clinical Relevance-Findings suggested that vacuum-assisted closure with silver-impregnated bandaging materials may provide advantages over traditional methods in the treatment of shell lesions in chelonians, including faster wound healing, improved cosmetic appearance of the healed wound, superior control of microbial contamination, and lower overall treatment costs.
C1 Utahs Hogle Zoo, Salt Lake City, UT 84108 USA.
   Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Columbia, MO 65211 USA.
   Washington Univ, Sch Med, St Louis, MO 63110 USA.
C3 University of Missouri System; University of Missouri Columbia;
   Washington University (WUSTL)
RP Adkesson, MJ (通讯作者)，Utahs Hogle Zoo, 2600 E Sunnyside Ave, Salt Lake City, UT 84108 USA.
OI Adkesson, Michael/0000-0002-8766-5296
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barten S L., 2006, Reptile Medicine and Surgery, V2nd, P893
   BENAMOTZ R, 2007, IN PRESS VET SURG
   Boyer TH., 2006, Reptile Medicine and Surgery, P696
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   CLAYTON L, 2003, P ASS REP AMPH VET, P103
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   Kirby JP, 2002, J TRAUMA, V53, P117, DOI 10.1097/00005373-200207000-00024
   Lafortune M, 2002, P AM ASS ZOO VET, P38
   Lafortune Maud, 2005, Journal of Herpetological Medicine and Surgery, V15, P4
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   LANZ OI, 2007, P N AM VET C, P1419
   McArthur Stuart, 2004, P403, DOI 10.1002/9780470698877.ch15
   McArthur Stuart, 2004, P35, DOI 10.1002/9780470698877.ch3
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   O'Malley B., 2005, CLIN ANATOMY PHYSL E
   Paul Julia Claire, 2005, Plast Surg Nurs, V25, P61
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
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   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
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   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
NR 31
TC 31
Z9 41
U1 0
U2 17
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD OCT 15
PY 2007
VL 231
IS 8
BP 1249
EP 1254
DI 10.2460/javma.231.8.1249
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 221RJ
UT WOS:000250244700027
PM 17937557
DA 2026-07-24
ER
PT J
AU Leijnen, M
   Steenvoorde, P
   van Doorn, LP
   da Costa, SA
   Schuttevaer, HM
   van Leeuwen, GAM
   Oskam, J
AF Leijnen, Michiel
   Steenvoorde, Pascal
   van Doorn, Louk P.
   da Costa, S. A.
   Schuttevaer, Herman M.
   van Leeuwen, Gijs A. M.
   Oskam, Jaques
TI A non-healing sinus of the lower leg 5 years after vacuum-assisted
   closure therapy due to a gossypiboma
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID SURGERY
AB Due to the development of vacuum-assisted closure therapy (V.A C.(R) Therapy (TM), KCl, San Antonio, Tex), chronic wound care has taken a step forward. Vacuum-assisted closure has proven to be effective in the treatment of chronic and acute wounds. Although most complications are rare, localized superficial skin irritation is the most common complication reported in the literature. Further complications involve pain, infection, bleeding, and fluid depletion. The authors present a case of a chronic fistula 5 years after vacuum-assisted closure therapy as a result of a piece of foam dressing that was left inside a wound. The retainment of vacuum-assisted closure dressings is a serious complication that can easily be prevented when proper precautions are taken during dressing changes.
C1 Rijnland Hosp, Dept Surg, Leiderdorp, Netherlands.
   Rijnland Wound Ctr, Leiderdorp, Netherlands.
   Rijnland Hosp, Dept Radiol, Leiderdorp, Netherlands.
   Rijnland Hosp, Dept Pathol, Leiderdorp, Netherlands.
C3 Rijnland Hospital; Rijnland Hospital; Rijnland Hospital
RP Leijnen, M (通讯作者)，Rijnland Hosp Leiderdorp, Simon Smitweg 1, Leiderdorp, Netherlands.
EM m.leijnen@rijnland.nl
CR ABDULKARIM FW, 1992, SKELETAL RADIOL, V21, P466
   Carson Stanley N, 2004, Ostomy Wound Manage, V50, P52
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
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   Gawande AA, 2003, NEW ENGL J MED, V348, P229, DOI 10.1056/NEJMsa021721
   Gwan-Nulla DN, 2001, ANN PLAS SURG, V47, P552, DOI 10.1097/00000637-200111000-00014
   Karl T, 2004, ZBL CHIR, V129, pS74, DOI 10.1055/s-2004-822609
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   LEIJNEN M, IN PRESS J WOUND CAR
   MORKYWAS MJ, 1997, ANN PLAST SURG, V38, P553
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   NEGATIVE PRESSUE WOU
NR 14
TC 6
Z9 7
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2007
VL 19
IS 8
BP 227
EP 230
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 222AD
UT WOS:000250267600005
PM 26110367
DA 2026-07-24
ER
PT J
AU Etoz, A
   Kahveci, R
AF Etoz, Abdullah
   Kahveci, Ramazan
TI Negative pressure wound therapy on diabetic foot ulcers
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EXPERIENCE; DEGLOVING INJURIES; TRIAL
AB The effects of negative pressure wound therapy ([NPWT], V.A.C.(R) Therapy, KCl, San Antonio, Tex) were compared with standard dressings in 45 patients with diabetic foot ulcers who were admitted to the Department of Plastic and Reconstructive Surgery, Medical Park, Hospital, Bursa, Turkey. Twenty-four patients were randomly divided into 2 groups-NPWT group and control group. Initially, the mean surface area of wounds in the NPWT group was 109 cm(2), the control. group 94.8 cm(2). The mean duration of open wound care was 11.25 days in the NPWT group and 15,35 days in the control group (P 0.05). After wound managment mean-surface-area of the diabetic. wounds was 88.6 cm(2) in the NPWT group, and 85.3 cm(2) in the control group (P < 0.05). The use of NPWT may be an effective initial wound therapy to achieve faster wound bed granulation in diabetic foot ulcers. Further studies are needed the effects and indications and to modify the technique of,this alternative treatment for use on nonhealing wounds.
RP Etoz, A (通讯作者)，Med Pk Hosp, Hasimiscan Caddesi,Fomara Meydani No 1 Osmangazi, Bursa, Turkey.
EM etoz@yahoo.com
RI /AAG-4626-2019
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   ATTINGER CE, 1997, GRABB SMITHS PLASTIC
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
   de Lange MY, 2000, EUR J PLAST SURG, V23, P178, DOI 10.1007/s002380050244
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
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   Joseph E, 2000, WOUNDS, V12, P60
   Josty IC, 2001, BRIT J PLAST SURG, V54, P363, DOI 10.1054/bjps.2000.3565
   Kirby JP, 2002, J TRAUMA, V53, P117, DOI 10.1097/00005373-200207000-00024
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
NR 13
TC 14
Z9 15
U1 0
U2 9
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2007
VL 19
IS 9
BP 250
EP 254
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 222AF
UT WOS:000250267800005
PM 25942747
DA 2026-07-24
ER
PT J
AU Segers, P
   Kloek, JJ
   Strackee, SD
   de Mol, BAJM
AF Segers, Patrique
   Kloek, Jaap J.
   Strackee, Simon D.
   de Mol, Bas A. J. M.
TI Open window thoracostomy: A new therapeutic option using topical
   negative pressure wound therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POSTPNEUMONECTOMY EMPYEMA; PARAPNEUMONIC
   EFFUSIONS; SURGERY; TRANSPOSITION; EXPERIENCE; MANAGEMENT
AB Open window thoracostomy (OWT) is an invasive treatment option for thoracic empyema that is seldom indicated. These wounds are accompanied with a prolonged hospital stay and significant patient discomfort over an extended period of time. A retrospective report was conducted on patients who underwent OWT at the Academic Medical Center (Amsterdam, The Netherlands) and evaluated if topical negative pressure therapy ([TNP], V.A.C.((R)) Therapy (TM), KCl Medical BV, Houten, The Netherlands) is a valid treatment Option for these wounds. Clinical outcome and applied management methods are analyzed. Between January 1986 and June 2005, 15 patients, with a mean age of 54. years, were treated with OWT. Recently, the authors have used TNP in combination with OWT as a new treatment modality to obtain rapid control over pleural bacterial load and to achieve a well-vascularized wound surface. Good clinical results and a trend toward shorter hospital stays and improved quality of life were seen.
   Open window thoracostomy as a treatment modality for thoracic empyema is a valid option but only when other means fail or are contraindicated. Treatment of open window thoracostomy in combination with TNP is a safe and adequate therapeutic option for thoracic empyema resulting in improved quality of life and overall shorter hospital stay.
C1 Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, NL-1105 AZ Amsterdam, Netherlands.
   Univ Eindhoven, Dept Biomed Engn, Eindhoven, Netherlands.
   Univ Amsterdam, Acad Med Ctr, Dept Plast & Reconstruct Surg, Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Eindhoven
   University of Technology; University of Amsterdam; Academic Medical
   Center Amsterdam
RP Segers, P (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM p.segers@amc.uva.nl
RI Strackee, Simon/AAN-1381-2020; Segers, Patrick/IWM-4183-2023
CR Anstadt MP, 2003, AM J MED SCI, V326, P9, DOI 10.1097/00000441-200307000-00002
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BOUROS D, 2004, PLEURAL DIS, V186, P353
   Colicc GL, 2000, CHEST, V118, P1158, DOI 10.1378/chest.118.4.1158
   DITTERICH D, 2004, ZENTRALBL CHIR, pS137
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NR 18
TC 1
Z9 1
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2007
VL 19
IS 10
BP 264
EP 269
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 222AH
UT WOS:000250268000006
PM 25942509
DA 2026-07-24
ER
PT J
AU Perez, D
   Wildi, S
   Demartines, N
   Bramkamp, M
   Koehler, C
   Clavien, PA
AF Perez, Daniel
   Wildi, Stefan
   Demartines, Nicolas
   Bramkamp, Matthias
   Koehler, Christian
   Clavien, Pierre-Alain
TI Prospective evaluation of vacuum-assisted closure in abdominal
   compartment syndrome and severe abdominal sepsis
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article
AB Background: Open abdomen treatment because of severe abdominal sepsis and abdominal compartment syndrome remains a difficult task. Different surgical techniques are available and are often used according to the surgeon's personal experience. Recently, the abdominal vacuum-assisted closure (VAC) system has been introduced, providing a new possibility to treat an open abdomen. In this study, we evaluate the role of this treatment option.
   Study design: This prospective observational cohort study includes 37 consecutive patients who were temporarily treated with VAC for severe abdominal sepsis or abdominal compartment syndrome, or both. Patients with abdominal trauma were excluded from the study. Thirty-seven patients undergoing major elective laparotomy and primary abdominal closure served as control group. Primary end points were fascial closure rate, physicoemotional recovery, and appearance outcomes 1 year after closure. Secondary end points included mortality, duration of open abdomen, length of ICU stay, and hospitalization time.
   Results: Abdomens were left open for 23 days (range 3 to 122 days) with 3.8 dressing changes (range 1 to 22) per patient. Abdominal closure was achieved in 70% (n = 26), with no marked relation to duration of open abdomen treatment (p > 0.05). After 3 months, patients with VAC treatment recovered to a physical and mental health status similar to patients in the control group (p > 0.05). This status remained stable until the end of the study. Aesthetic outcomes (according to the Vancouver Scar Scale) were considerably poorer in the VAC group compared with controls (p < 0.01).
   Conclusions: Treatment of laparostomy with VAC for abdominal sepsis and abdominal compartment syndrome results in a high rate of successful abdominal closure. In addition, patients recover more rapidly, although hypertrophic scars might interfere with body perception. We recommend abdominal VAC system as first option if open abdomen treatment is indicated.
C1 Univ Zurich Hosp, Dept Visceral & Transplantat Surg, CH-8091 Zurich, Switzerland.
   Univ Zurich Hosp, Dept Internal Med, CH-8091 Zurich, Switzerland.
   Univ Zurich Hosp, Dept Plast & Reconstruct Surg, CH-8091 Zurich, Switzerland.
   Univ Lausanne Hosp, Dept Visceral Surg, Lausanne, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital; University of Zurich; University Zurich
   Hospital; University of Lausanne; Centre Hospitalier Universitaire
   Vaudois (CHUV)
RP Clavien, PA (通讯作者)，Univ Zurich Hosp, Dept Visceral & Transplantat Surg, Raemistr 100, CH-8091 Zurich, Switzerland.
EM clavien@chir.unizh.ch
OI Perez, Daniel/0000-0002-3154-7311; Demartines,
   Nicolas/0000-0002-1530-3114
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NR 36
TC 148
Z9 164
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD OCT
PY 2007
VL 205
IS 4
BP 586
EP 592
DI 10.1016/j.jamcollsurg.2007.05.015
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 222QP
UT WOS:000250312300010
PM 17903734
DA 2026-07-24
ER
PT J
AU Matzi, V
   Lindenmann, J
   Porubsky, C
   Neuboeck, N
   Maier, A
   Smolle-Juettner, FM
AF Matzi, Veronika
   Lindenmann, Joerg
   Porubsky, Christian
   Neuboeck, Nicole
   Maier, Alfred
   Smolle-Juettner, Frevja Maria
TI Intrathoracic insertion of the VAC device in a case of pleural empyema
   20 years after pneumonectorny
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID ASSISTED CLOSURE; WOUND CONTROL; MANAGEMENT
AB We report a 72-year-old man suffering from pleural empyema after pneumonectomy due to nonsmall cell lung cancer 20 years previously. Insufficiency of the bronchial stump was ruled out by bronchoscopy and bronchography. Thoracic computed tomographic scan of the thorax detected an abscess located in the subcutaneous tissue of the right ventrolateral chest wall originating from severe pyogenic osteomyelitis of the fifth and sixth ribs. Our surgical management included partial resection of the chest wall followed by insertion of the vacuum-assisted closure system into the thoracic cavity. The patient fully recovered and was discharged on postoperative day 32.
C1 Med Univ Graz, Dept Gen Surg, Div Thorac & Hyperbar Surg, A-8036 Graz, Austria.
C3 Medical University of Graz
RP Lindenmann, J (通讯作者)，Med Univ Graz, Dept Gen Surg, Div Thorac & Hyperbar Surg, Auenbruggerpl 29, A-8036 Graz, Austria.
EM jo.lindenmann@meduni-graz.at
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Ditterich D, 2006, ZBL CHIR, V131, pS133, DOI 10.1055/s-2006-921499
   Massera F, 2006, ANN THORAC SURG, V82, P288, DOI 10.1016/j.athoracsur.2005.11.046
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   Robinson S., 1915, COLLECTED PAPERS MAY, V7, P618
   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
NR 7
TC 12
Z9 15
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD NOV
PY 2007
VL 84
IS 5
BP 1762
EP 1764
DI 10.1016/j.athoracsur.2007.05.052
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 229DF
UT WOS:000250782500060
PM 17954112
OA Bronze
DA 2026-07-24
ER
PT J
AU Hadamitzky, CD
   Schulte, S
   Horsch, S
AF Hadamitzky, C. Domingos
   Schulte, S.
   Horsch, S.
TI Vacuum assisted wound closure in postoperative periprosthetic groin
   infections: a new gold standard?
SO JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE postoperative complications; infections; vacuum assisted closure; wound
   infection
ID SARTORIUS MYOPLASTY; NEGATIVE-PRESSURE; VASCULAR GRAFTS; MANAGEMENT;
   THERAPY
AB Aim This study was designed to control the results of conservative treatment using vacuum assisted wound closure (VAWC) applied exclusively to cases of deep groin infections with involvement of alloplastic graft material.
   Methods. During a 2 year period 10 patients with 11 deep inguinal infections involving alloplastic graft material were treated with supportive VAWC. Intraoperative management included extensive debridement, sartorius myoplastic and VAWC application. A retrospective case-note review was performed. Variables comorbidity, surgical management of the infection, microbiological results, complications and Doppler results were analysed.
   Results. Six early graft infections (< 30 days after implantation) and 5 late infections were treated. In 3 cases (27.3%) the infected graft material was replaced by a silver-coated Dacron prosthesis. The mean duration of VAWC was 16 +/- 7.7 days; postoperative mean hospital stay was 25.3 +/- 8.5 days. Mean postoperative follow-up was 13.1 months with no procedure-related mortality.
   Conclusion Even in the presence of synthetic vascular graft material, negative pressure therapy can greatly simplify challenging wound healing problems under maintenance of the alloplastic grafts. These preliminary results demonstrate the safety and effectiveness of VAWC for the treatment of deep alloplastic graft infections.
C1 Univ Cologne, Dept Vasc Surg, Hosp Porz Rhein, D-51149 Cologne, Germany.
C3 University of Cologne
RP Hadamitzky, CD (通讯作者)，Univ Cologne, Dept Vasc Surg, Hosp Porz Rhein, Urbacher Weg 19, D-51149 Cologne, Germany.
EM c.hadamitzky@btinternet.com
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NR 18
TC 16
Z9 16
U1 0
U2 0
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0021-9509
EI 1827-191X
J9 J CARDIOVASC SURG
JI J. Cardiovasc. Surg.
PD AUG
PY 2007
VL 48
IS 4
BP 477
EP 483
PG 7
WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 229WN
UT WOS:000250837000008
PM 17653008
DA 2026-07-24
ER
PT J
AU McNulty, AK
   Schmidt, M
   Feeley, T
   Kieswetter, K
AF McNulty, Amy K.
   Schmidt, Marisa
   Feeley, Teri
   Kieswetter, Kris
TI Effects of negative pressure wound therapy on fibroblast viability,
   chemotactic signaling, and proliferation in a provisional wound (fibrin)
   matrix
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CELLS; FOOT; MYOFIBROBLASTS; MECHANOBIOLOGY;
   BIOLOGY
AB Vacuum Assisted Closure (R) brand Negative Pressure Wound Therapy (V.A.C.(R) NPWT) has been shown to be an effective therapeutic option for the treatment of recalcitrant wounds; however, the mechanism of action at the cellular level remains to be elucidated. Here, we examined the effects of negative pressure wound therapy, manifolded with two different dressings, on fibroblast viability, chemotactic signaling, and proliferation in a fibrin clot matrix. Fibroblasts were grown in a three-dimensional fibrin matrix and were treated for 48 hours with either V.A.C.(R) NPWT and GranuFoam (R) Dressing, or with gauze under suction, or as static controls without negative pressure or dressings. Cells treated by gauze under suction showed significantly greater cell death and stimulated less migration and proliferation than static and V.A.C.(R) NPWT-treated cells (p < 0.05). Apoptosis was also significantly higher in gauze under suction than in static treatments. These results indicate that the dressing material has a significant effect on cell response following negative pressure wound therapy. The ability to support cell growth, stimulate chemotaxis, and proliferation without increasing apoptosis may provide an insight into the mechanisms of action of V.A.C.(R) NPWT.
C1 [McNulty, Amy K.; Schmidt, Marisa; Feeley, Teri; Kieswetter, Kris] Kinet Concepts Inc, San Antonio, TX USA.
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NR 38
TC 125
Z9 153
U1 1
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2007
VL 15
IS 6
BP 838
EP 846
DI 10.1111/j.1524-475X.2007.00287.x
PG 9
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 232OR
UT WOS:000251029500142
PM 18028132
DA 2026-07-24
ER
PT J
AU D'Hondt, M
   Devriendt, D
   Van Rooy, F
   Vansteenkiste, F
AF D'Hondt, M.
   Devriendt, D.
   Van Rooy, F.
   Vansteenkiste, F.
TI Systemic peritoneal cavity lavage : a new strategy for treatment of the
   open septic abdomen
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE peritonitis; laparostomy; vacuum assisted closure (VAC)
AB Introduction : Management of the open abdomen is a challenge, certainly when fistulisation is present. This paper presents a new treatment modality for this specific situation.
   Methods : Abdominal sepsis increases the net flow across the peritoneum to 300-500 ml/h. This flow was used to clean and flush the abdomen. Meropenem was administered, as antibiotic concentration in the peritoneal cavity is known to reach therapeutic levels after 8 hours. The abdominal fluid was captured using the abdominal VAC system and additional drains. The total amount of drained fluid was compensated intravenously. Thus, the concept was named "Systemic Peritoneal Cavity Lavage" (SPCL).
   Results : Four patients with an open abdomen and severe abdominal sepsis were treated with SPCL and got out of their septic state within two weeks despite fistulisation and ongoing bowel leakage in three patients. A partial enterectomy with removal of the fistulas could be performed six weeks later.
   Conclusion : SPCL is a promising method to treat patients with severe abdominal sepsis. In combination with the fistula isolation technique it permits delayed treatment of fistulas in a hostile abdomen where immediate removal of the septic focus is impossible.
C1 AZ Groeninge Hosp, Dept Digest Surg, B-8500 Kortrijk, Belgium.
RP D'Hondt, M (通讯作者)，AZ Groeninge Hosp, Dept Digest Surg, Reepkaai 4, B-8500 Kortrijk, Belgium.
EM mathieudhondt2000@yahoo.com
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   Marshall JC, 2003, CRIT CARE MED, V31, P2228, DOI 10.1097/01.CCM.0000087326.59341.51
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NR 7
TC 3
Z9 3
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD OCT
PY 2007
VL 107
IS 5
BP 583
EP 587
DI 10.1080/00015458.2007.11680130
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 234KU
UT WOS:000251163800024
PM 18074927
DA 2026-07-24
ER
PT J
AU Strecker, T
   Rösch, J
   Horch, RE
   Weyand, M
   Kneser, U
AF Strecker, Thomas
   Roesch, Johannes
   Horch, Raymund E.
   Weyand, Michael
   Kneser, Ulrich
TI Sternal wound infections following cardiac surgery:: Risk factor
   analysis and interdisciplinary treatment
SO HEART SURGERY FORUM
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RECTUS-ABDOMINIS MUSCLE; MYOCUTANEOUS
   ADVANCEMENT FLAPS; CHEST-WALL RECONSTRUCTION; SINGLE-STAGE MANAGEMENT;
   MUSCULOCUTANEOUS FLAPS; MEDIASTINAL INFECTION; DEFINITIVE CLOSURE;
   GREATER OMENTUM; HEART SURGERY
AB Objective. Sternal wound infections are a serious complication after cardiac surgery. Although a variety of treatment algorithms has been published, the ideal operative treatment of complicated median sternotomy wounds is the subject of ongoing controversy.
   Methods. In a retrospective review, 3016 consecutive open-heart surgery patients between January 2003 and June 2006 were evaluated: 65.6% underwent coronary artery bypass surgery (CABG), 16.3% cardiac valve replacement, 13.5% combined CABG and valve replacement, 2.8% aortic reconstruction or replacement, 0.6% artificial heart implantation, and 1.2% cardiac transplantation.
   Results. Sixty-three patients (2.1%) developed sternal wound infections. Fifty-six wounds were treated with debridement, irrigation, and re-wiring. Thirty-four patients were treated using vacuum-assisted closure therapy. Nineteen of these patients eventually required plastic surgical coverage with either rectus abdominis or pectoralis major flaps. Diabetes mellitus, rethoracotomy, duration of operation and, interestingly, the time of operation (morning versus afternoon) presented significant risk factors for development of sternal wound infections (P < .05). Three patients developed partial flap necrosis and required a second flap. Eventually, all defects were successfully reconstructed and there was no recurrent ostemyelitis noticed over the entire observation period (follow-up, 23 +/- 13 months).
   Discussion. Patients at risk for development of sternal wound infections may be preferably operated in the morning at first position. Vaccuum-assisted closure therapy acts as a link between radical debridement and definitive plastic coverage. The type of flap is individually chosen based on location of the defect and availability of certain vascular axis. The presented interdisciplinary approach with radical surgical debridement, application of subatmospheric pressure dressings, and early involvement of the plastic surgical team allows efficient treatment of infected median sternotomy wounds.
C1 Univ Erlangen Nurnberg, Ctr Cardiac Surg, D-91054 Erlangen, Germany.
   Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Strecker, T (通讯作者)，Univ Erlangen Nurnberg, Ctr Cardiac Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM thomas.strecker@herz.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
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NR 38
TC 38
Z9 42
U1 0
U2 3
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PD OCT
PY 2007
VL 10
IS 5
BP E366
EP E371
DI 10.1532/HSF98.20071079
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 236MW
UT WOS:000251308100004
PM 17855200
OA gold
DA 2026-07-24
ER
PT J
AU Siegel, HJ
   Long, JL
   Watson, KM
   Fiveash, JB
AF Siegel, Herrick J.
   Long, James L.
   Watson, Kevin M.
   Fiveash, John B.
TI Vacuum-assisted closure for radiation-associated wound complications
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE vacuum assisted closure; wound complication; radiation necrosis; wound
   management; soft tissue sarcoma
ID SOFT-TISSUE SARCOMA; THERAPY; RADIOTHERAPY; BRACHYTHERAPY; EXTREMITY;
   RESECTION
AB Background and Objectives: Vacuum-assisted closure (VAC) technology has proven to be effective in the management of soft tissue loss from infections, vascular insufficiency, and traumatic disorders and may have a similar benefit in the musculoskeletal oncology patient. This study reports a single institution's experience with VAC technology in the management of radiation-associated wound complications in patients with soft tissue sarcomas.
   Materials: Twenty-two patients treated with both surgical intervention and radiation therapy developed either superficial or deep wound complications that were managed with the VAC device. This study group was compared to a retrospectively identified comparison group of 19 patients, in which the VAC device was not used.
   Results: Hospital stay (P < 0.025), length of overall treatment (P < 0.025), number of operative debridements (P < 0.05) and success of wound closure without the need for soft tissue transposition (P < 0.01) was found to be significantly less in the study groups as compared to those not treated with the VAC device.
   Conclusion: VAC technology appears to be safe and effective in the treatment of radiation-associated wound complications.
C1 Univ Alabama Birmingham, Dept Surg, Div Orthopaed Surg, Birmingham, AL USA.
   Univ Alabama Birmingham, Dept Surg, Div Plast Surg, Birmingham, AL USA.
   Univ Alabama Birmingham, Dept Radiat Oncol, Birmingham, AL USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Siegel, HJ (通讯作者)，FOT 920, 1530 3rd Ave S, Birmingham, AL 35294 USA.
EM herrick.siegel@ortho.uab.edu
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NR 21
TC 29
Z9 33
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD DEC 1
PY 2007
VL 96
IS 7
BP 575
EP 582
DI 10.1002/jso.20846
PG 8
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 238UL
UT WOS:000251473100009
PM 17999398
DA 2026-07-24
ER
PT J
AU Thompson, JT
   Marks, MW
AF Thompson, James T.
   Marks, Malcolm W.
TI Negative pressure wound therapy
SO CLINICS IN PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; SOFT-TISSUE
   INJURIES; SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE; FASCIAL
   CLOSURE; OPEN ABDOMEN; SWINE MODEL; MANAGEMENT; DEVICE
AB NPWT has proven to be a revolutionary breakthrough in wound management. Wounds that previously were cumbersome to deal with or were in a chronic, nonhealing state have become manageable. Wounds with exposed bone, tendon, or hardware also have been managed successfully. Numerous adjunctive uses also have been described, showing the versatility and reliability of this method of wound management. The scientific explanations of the benefits of topical negative pressure are ongoing. At the least, multiple elements in the wound-healing process are affected or somehow modified by NPWT. The decision to use any new medical technology must include a cost assessment. NPWT management of a wound incurs some higher costs for the materials that include the sponges, occlusive drapes, and the vacuum machine, which must be rented per diem; however, the duration of dressing changes until final wound healing or definitive wound closure is shorter, compensating for the costs of the materials. Furthermore, as physicians, nurses, and home care specialists become more experienced and adept at managing NPWT, there will be a decrease in the time required. Patients can now be discharged to home while still receiving therapy, thus reducing the need for prolonged inpatient care and these inherent costs. Two recent studies found the cost effectiveness to be comparable to traditional wound therapy with-clinical benefits [54,55].
   NPWT should be considered an important part of the armamentarium for any plastic surgeon dealing with wounds. In the future, there is likely to be a wide range of products and potential indications as this technology continues to evolve.
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University
RP Thompson, JT (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
EM jimthomp@wfubmc.edu
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NR 56
TC 65
Z9 74
U1 1
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0094-1298
EI 1558-0504
J9 CLIN PLAST SURG
JI Clin. Plast. Surg.
PD OCT
PY 2007
VL 34
IS 4
BP 673
EP +
DI 10.1016/j.cps.2007.07.005
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 238US
UT WOS:000251473800007
PM 17967622
DA 2026-07-24
ER
PT J
AU Wilkes, RP
   McNulty, AK
   Feeley, TD
   Schmidt, MA
   Kieswetter, K
AF Wilkes, Robert P.
   McNulty, Amy K.
   Feeley, Teri D.
   Schmidt, Marisa A.
   Kieswetter, Kris
TI Bioreactor for application of subatmospheric pressure to
   three-dimensional cell culture
SO TISSUE ENGINEERING
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COLLAGEN-MATRIX; IN-VITRO; FIBROBLASTS; WOUNDS;
   MECHANOTRANSDUCTION; DIFFERENTIATION; PROLIFERATION; STIMULATION;
   FOUNDATION
AB Vacuum-assisted closure (VAC) negative pressure wound therapy (NPWT) is a highly successful and widely used treatment modality for wound healing, although no apparatus exists to monitor the effects of subatmospheric pressure application in vitro. Such an apparatus is desirable to better understand the biological effects of this therapy and potentially improve upon them. This article describes the development and validation of a novel bioreactor that permits such study. Tissue analogues consisting of 3-dimensional fibroblast-containing fibrin clots were cultured in off-the-shelf disposable cell culture inserts and multiwell plates that were integrated into the bioreactor module. Negative pressure dressings, commercialized for wound therapy, were placed on top of the culture, and subatmospheric pressure was applied to the dressing. Cultures were perfused with media at controlled physiologic wound exudate flow rates. The design of this bioreactor permits observation of the culture using an inverted microscope in brightfield and fluorescence modes and sustained incubation of the system in a 5% carbon dioxide atmosphere. This closed-system mimics the wound micro-environment under VAC NPWT. Matrix compression occurs as the subatmospheric pressure draws the dressing material down. At the contact zone, surface undulations were clearly evident on the fibroblast-containing tissue analogues at 24 h and appeared to correspond to the dressing microstructure. The bioreactor design, consisting of sterilizable machined plastics and disposable labware, can be easily scaled to multiple units. Validation experiments show that cell survival in this system is comparable with that seen in cells grown in static tissue culture. After application of VAC NPWT, cell morphology changed, with cells appearing thicker and with an organized actin cytoskeleton. The development and validation of this new culture system establishes a stable platform for in vitro investigations of subatmospheric pressure application to tissues.
C1 [Wilkes, Robert P.; McNulty, Amy K.; Feeley, Teri D.; Schmidt, Marisa A.; Kieswetter, Kris] Kinetic Concepts Inc, San Antonio, TX USA.
RP Wilkes, RP (通讯作者)，Kinetic Concepts Inc, San Antonio, TX USA.
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NR 27
TC 20
Z9 26
U1 0
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2152-4947
J9 TISSUE ENG
JI Tissue Eng.
PD DEC
PY 2007
VL 13
IS 12
BP 3003
EP 3010
DI 10.1089/ten.2007.0036
PG 8
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 243HW
UT WOS:000251788400020
PM 17988192
DA 2026-07-24
ER
PT J
AU Heller, L
   Ballo, MT
   Cormier, JN
   Oates, SD
   Butler, CE
AF Heller, Lior
   Ballo, Matthew T.
   Cormier, Janice N.
   Oates, Scott D.
   Butler, Charles E.
TI Staged reconstruction for resection wounds in sarcoma patients treated
   with brachytherapy
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE surgical flaps; sarcoma; brachytherapy; radiotherapy; microsurgery;
   wound healing; VAC; vacuum-assisted closure
ID SOFT-TISSUE SARCOMA; ADJUVANT RADIATION-THERAPY; PRIOR SURGERY;
   EXTREMITY; COMPLICATIONS; IRRADIATION; MANAGEMENT
AB Adjuvant brachytherapy reduces local recurrences following wide local excision of large, high-grade sarcomas; but its use with immediate flap reconstruction is associated with a high wound complication rate following previous radiotherapy. To avoid flap irradiation and reduce wound-healing morbidity, a treatment strategy using negative-pressure wound therapy (NPWT) for temporary wound coverage during brachytherapy followed by delayed flap reconstruction was used in 3 previously irradiated sarcoma patients. NPWT was continued after brachytherapy catheter removal to stimulate vascularization, granulation, and wound contraction. Flap reconstructions were performed after the adequacy of the resection margins was pathologically confirmed and the wound bed appeared grossly vascularized. Prior to reconstruction, 2 patients required additional excision of positive or close permanent-section surgical margins. There were no major wound-healing complications during 9-18 months' follow-up. Staged closure using this approach may have advantages over immediate flap reconstruction in some sarcoma patients. Potential advantages include avoiding flap irradiation, reducing wound size and magnitude of the reconstructive procedure, and ensuring tumor-free surgical margins before definitive reconstruction.
C1 [Heller, Lior; Oates, Scott D.; Butler, Charles E.] Univ Texas MD Anderson Canc Ctr, Dept Plast Surg, Houston, TX 77030 USA.
   [Ballo, Matthew T.] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA.
   [Cormier, Janice N.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center; University of Texas System;
   UTMD Anderson Cancer Center
RP Butler, CE (通讯作者)，Univ Texas MD Anderson Canc Ctr, Dept Plast Surg, Unit 443,1515 Holcombe Blvd, Houston, TX 77030 USA.
EM cbutler@mdanderson.org
RI Butler, Charles/GOH-1645-2022
OI Ballo, Matthew/0000-0003-0270-8726
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NR 15
TC 13
Z9 14
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JAN
PY 2008
VL 60
IS 1
BP 58
EP 63
DI 10.1097/01.sap.0000258956.66990.9a
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 243UL
UT WOS:000251822700016
PM 18281799
DA 2026-07-24
ER
PT J
AU Becker, HP
   Willms, A
   Schwab, R
AF Becker, Horst Peter
   Willms, A.
   Schwab, R.
TI Small bowel fistulas and the open abdomen
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Review
DE fistula; small bowel; open abdomen; damage control; laparostomy;
   vacuum-assisted closure
ID ABDOMINAL-WALL DEFECTS; FASCIAL CLOSURE; VENTRAL HERNIA; ENTEROCUTANEOUS
   FISTULAS; TEMPORARY CLOSURE; WOUND CLOSURE; MANAGEMENT; RECONSTRUCTION;
   EXPERIENCE; SEPARATION
AB Over the last 15 years, the contemporary strategies to treat the open abdomen have reduced the lethal complications. Systematic intensive care and modern wound management in conjunction with a plastic barrier to protect the viscera and topical negative pressure on the soft tissues have reduced the development of small bowel fistulas. The literature selected for this review shows that the surgical handling of the exposed bowel, the choice of the material for temporary coverage and early progressive closure of the defect are crucial for the prevention of fistulas. At present, surgeons worldwide have adopted these principles leading to an increase of primary or delayed closure rates. When a small fistula occurs, biological dressings like human acellular dermal matrix and fibrin glue may help to seal the orifice and to treat the patient conservatively. In case of a large fistula, vacuum-assisted wound management is recommended as well. Through a separate hole in the vacuum sponge matching to the fistula, the enteric contents are sucked off while the wound bed heals and is prepared for split thickness skin graft. Surgical resection of established fistula unresponsive to conservative measures should only be performed on patients well-nourished and free of infection with a delay of at least six months. For patients with an open abdomen, surgical expertise and a well-structured management plan offer the best chances to overcome this potentially devastating condition - with or without fistula.
C1 [Becker, Horst Peter; Willms, A.; Schwab, R.] Cent Mil Hosp, Dept Gen Abdominal & Thorac Surg, D-56072 Koblenz, Germany.
RP Becker, HP (通讯作者)，Cent Mil Hosp, Dept Gen Abdominal & Thorac Surg, Ruebenacher Str 170, D-56072 Koblenz, Germany.
EM horstpeter.becker@t-online.de
RI Willms, Arnulf/AFN-0812-2022
OI Willms, Arnulf/0000-0001-9998-6735
CR Adkins AL, 2004, AM SURGEON, V70, P137
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NR 44
TC 80
Z9 95
U1 1
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PY 2007
VL 96
IS 4
BP 263
EP 271
DI 10.1177/145749690709600402
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 243VM
UT WOS:000251825400002
PM 18265852
DA 2026-07-24
ER
PT J
AU Gäddnäs, F
   Saarnio, J
   Ala-Kokko, T
   Laurila, J
   Koivukangas, V
AF Gaddnas, F.
   Saarnio, J.
   Ala-Kokko, T.
   Laurila, J.
   Koivukangas, V.
TI Continuous retention suture for the management of open abdomen:: A high
   rate of delayed fascial closure
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE open abdomen; abdominal compartment syndrome; damage control surgery;
   vacuum assisted closure; relaparotomy; laparostomy; surgical infection
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM PACK TECHNIQUE; DAMAGE-CONTROL;
   TEMPORARY CLOSURE; PERITONITIS; RELAPAROTOMY; EXPERIENCE; MORTALITY;
   WOUNDS; TRAUMA
AB Background and Aims: Open abdomen is most often a consequence of damage control surgery, abdominal decompression or intra-abdominal infections. Ventral hernia after unsuccessful closure of open abdomen causes marked disability to the patient. Several methods for delayed fascial closure have been developed. Patients treated with continuous retention suture were evaluated to find out how often fascial closure was achieved, and what complications were related to the technique.
   Method: A retrospective analysis of 16 open abdomen patients treated with continuous retention suture.
   Results: The most common cause of open abdomen was abdominal infection. Complete fascial closure was achieved in nine of the eleven surviving patients. Closure failed in one patient. Partial closure was also achieved in one patient. The median time between leaving the abdomen open and starting the process of closure was twelve days. The longest period of open abdomen before successful fascial closure was 29 days. Five patients died before the process of closure was complete.
   Conclusion: Delayed fascial closure can be accomplished by using the retention suture method described here.
C1 [Gaddnas, F.; Koivukangas, V.] Oulu Univ Hosp, Dept Surg, FIN-90029 Oulu, Finland.
   [Gaddnas, F.; Ala-Kokko, T.; Laurila, J.] Oulu Univ Hosp, Dept Anesthesiol, Div Intens Care, Oulu, Finland.
C3 University of Oulu; University of Oulu
RP Koivukangas, V (通讯作者)，Oulu Univ Hosp, Dept Surg, PL 21, FIN-90029 Oulu, Finland.
EM vesa.koivukangas@oulu.fi
OI Gäddnäs, Fiia/0000-0002-9825-5014
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   BENDER JS, 1994, J TRAUMA, V36, P182, DOI 10.1097/00005373-199402000-00005
   BROCK WB, 1995, AM SURGEON, V61, P30
   Cheatham ML, 2004, J TRAUMA, V56, P237, DOI 10.1097/01.TA.0000109858.55483.86
   Cipolla J, 2005, AM SURGEON, V71, P202
   Cothren CC, 2006, AM J SURG, V192, P238, DOI 10.1016/j.amjsurg.2006.04.010
   Howdieshell TR, 2004, AM J SURG, V188, P301, DOI 10.1016/j.amjsurg.2004.03.007
   Koniaris LG, 2001, ARCH SURG-CHICAGO, V136, P1359, DOI 10.1001/archsurg.136.12.1359
   Koperna T, 2000, WORLD J SURG, V24, P32, DOI 10.1007/s002689910007
   Lamme B, 2004, BJS-BRIT J SURG, V91, P1046, DOI 10.1002/bjs.4517
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   Loveland JA, 2004, BRIT J SURG, V91, P1095, DOI 10.1002/bjs.4641
   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
   Miller RS, 2005, J TRAUMA, V59, P1365, DOI 10.1097/01.ta.0000196004.49422.af
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   Stone PA, 2004, J TRAUMA, V57, P1082, DOI 10.1097/01.TA.0000149248.02598.9E
   Sugrue M, 2004, INJURY, V35, P642, DOI 10.1016/j.injury.2004.03.011
NR 23
TC 18
Z9 19
U1 0
U2 1
PU FINNISH SURGICAL SOC
PI HELSINKI
PA MAKELANKATU 2 C, PO BOX 49, SF-00501 HELSINKI, FINLAND
SN 1457-4969
J9 SCAND J SURG
JI Scand. J. Surg.
PY 2007
VL 96
IS 4
BP 301
EP 307
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 243VM
UT WOS:000251825400008
PM 18265858
DA 2026-07-24
ER
PT J
AU Easterlin, B
   Bromberg, W
   Linscott, J
AF Easterlin, Bradley
   Bromberg, William
   Linscott, Jack
TI A novel technique of vacuum-assisted wound closure that functions as a
   delayed primary closure
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
AB Contaminated midline abdominal wounds are often left open and allowed to close via secondary intention to prevent surgical site infections. Negative pressure wound therapy (NPWT) devices have decreased time of healing by secondary intention when compared to the prior standard of moist dressings. The authors report a modification of NPWT that utilizes the unique characteristics of the negative pressure system to achieve delayed primary closure while preventing surgical site infections by continuously draining the wound effluent.
C1 [Easterlin, Bradley; Bromberg, William; Linscott, Jack] Mem Hlth Univ Med Ctr, Savannah, GA 31404 USA.
RP Easterlin, B (通讯作者)，Mem Hlth Univ Med Ctr, 4700 Waters Ave, Savannah, GA 31404 USA.
EM easterlin_nb@yahoo.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell PE, 1999, WOUND REPAIR REGEN, V7, pA287
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   WYSOCKI AB, 1993, J INVEST DERMATOL, V101, P64, DOI 10.1111/1523-1747.ep12359590
NR 5
TC 11
Z9 18
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2007
VL 19
IS 12
BP 331
EP 333
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 245HF
UT WOS:000251925000002
PM 25942681
DA 2026-07-24
ER
PT J
AU Benninger, E
   Labler, L
   Seifert, B
   Trentz, O
   Menger, MD
   Meier, C
AF Benninger, Emanuel
   Labler, Ludwig
   Seifert, Burkhardt
   Trentz, Otmar
   Menger, Michael D.
   Meier, Christoph
TI In vitro comparison of intra-abdominal hypertension development
   after different temporary abdominal closure techniques
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE temporary abdominal closure; intra-abdominal pressure; intra-abdominal
   hypertension; abdominal compartment syndrome; vacuum assisted closure;
   VAC
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; COMPARTMENT SYNDROME; FASCIAL
   CLOSURE; SILO CLOSURE; TRAUMA; FOUNDATION; WOUNDS
AB Background. To compare volume reserve capacity (VRC) and development of intra-abdominal hypertension after different in vitro temporary abdominal closure (TAC) techniques.
   Methods. A model of the abdomen was designed. The abdominal wall was simulated with polychloroprene, a synthetic rubber compound. A lentil-shaped defect of 150 cm(2) was cut into the anterior aspect of the abdominal wall. TAC of this defect was performed by a zipper system (ZS), a bag silo closure (BSC), or a vacuum assisted closure (VAC) with subatmospheric pressures ranging from 0- to 200 mmHg. The model with intact abdominal wall served as reference. The model was filled with water to baseline level. The intra-abdominal pressure was increased in 2 mmHg steps from baseline level (6 mmHg) to 40 mmHg by adding volume to the system according to a standardized protocol. VRC with corresponding intra-abdominal pressure were analyzed and compared for the different TAC techniques.
   Results. VRC was the highest after BSC at all pressure levels studied (P < 0.05). VAC and ZS resulted in significantly lower VRC compared with BSC and reference (P < 0.05). The magnitude of negative pressure on the VAC did not significantly influence the VRC.
   Conclusions. In the present in vitro model, BSC demonstrated the highest VRC of all evaluated TAC techniques. Different levels of subatmospheric pressures applied to the VAC did not affect VRC. The results for ZS and VAC indicate that these TAC techniques may increase the risk for recurrent intra-abdominal hypertension and should therefore not be used in high-risk patients during the initial phase after abdominal decompression. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Benninger, Emanuel; Labler, Ludwig; Trentz, Otmar; Meier, Christoph] Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland.
   [Seifert, Burkhardt] Univ Zurich, ISPM, Dept Biostat, Zurich, Switzerland.
   [Menger, Michael D.] Univ Saarland, Inst Clin & Expt Surg, D-6650 Homburg, Germany.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   Saarland University
RP Meier, C (通讯作者)，Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Raemistr 100, CH-8091 Zurich, Switzerland.
EM meierpucillo@hispeed.ch
OI Seifert, Burkhardt/0000-0002-5829-2478
CR [Anonymous], EUR J TRAUMA
   BROCK WB, 1995, AM SURGEON, V61, P30
   Cothren CC, 2006, AM J SURG, V192, P238, DOI 10.1016/j.amjsurg.2006.04.010
   CUESTA MA, 1991, WORLD J SURG, V15, P74, DOI 10.1007/BF01658968
   De Waele JJ, 2006, CRIT CARE, V10, DOI 10.1186/cc4870
   Fernandez L, 1996, J TRAUMA, V40, P258, DOI 10.1097/00005373-199602000-00014
   Gracias VH, 2002, ARCH SURG-CHICAGO, V137, P1298, DOI 10.1001/archsurg.137.11.1298
   Kaplan Mark, 2004, Ostomy Wound Manage, V50, P1
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Oetting P, 2006, CHIRURG, V77, P586, DOI 10.1007/s00104-006-1200-9
   Stone PA, 2004, J TRAUMA, V57, P1082, DOI 10.1097/01.TA.0000149248.02598.9E
   Suliburk JW, 2003, J TRAUMA, V55, P1155, DOI 10.1097/01.TA.0000100218.03754.6A
   Tremblay LN, 2001, AM J SURG, V182, P670, DOI 10.1016/S0002-9610(01)00805-4
NR 15
TC 16
Z9 16
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
J9 J SURG RES
JI J. Surg. Res.
PD JAN
PY 2008
VL 144
IS 1
BP 102
EP 106
DI 10.1016/j.jss.2007.02.021
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 246MA
UT WOS:000252009900015
PM 17764694
DA 2026-07-24
ER
PT J
AU Gasbarro, R
AF Gasbarro, Ron
TI Negative pressure wound therapy: A clinical review
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BLOOD-FLOW; FIBROBLASTS; GROWTH; ULCERS; TRIAL
CR Ågren MS, 1999, J INVEST DERMATOL, V112, P463, DOI 10.1046/j.1523-1747.1999.00549.x
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Luckraz H, 2003, J THORAC CARDIOV SUR, V125, P301, DOI 10.1067/mtc.2003.74
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Schwien T, 2005, OSTOMY WOUND MANAG, V51, P47
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
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   TEOT L, VAC VACUUM ASSISTED
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   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
NR 19
TC 5
Z9 6
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2007
VL 19
IS 12
SU S
BP 2
EP 7
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 247OG
UT WOS:000252088600001
DA 2026-07-24
ER
PT J
AU Lavery, LA
   Seaman, JW
   Barnes, SA
   Armstrong, DG
   Keith, MS
AF Lavery, Lawrence A.
   Seaman, John W., Jr.
   Barnes, Sunni A.
   Armstrong, David G.
   Keith, Michael S.
TI Prediction of healing for postoperative diabetic foot wounds based on
   early wound area progression
SO DIABETES CARE
LA English
DT Article
ID ULCERS; DRESSINGS; TRIAL
AB OBJECTIVE - To evaluate the probability of wound healing based on percentage of wound area reduction (PWAR) at 1 and 4 weeks in individuals with large, chronic, nonischemic diabetic foot wounds following partial foot amputation.
   METHODS - Data from a 16-week randomized clinical trial (RCT) of 162 patients were analyzed to compare outcomes associated with negative-pressure wound therapy (NPWT) delivered through the V.A.C. Therapy System (Kinetic Concepts, San Antonio, TX) (n = 77) versus standard moist wound therapy (MWT) (n = 85). The 1- and 4-week regression models included 153 and 129 of the RCT patients, respectively.
   RESULTS - Early changes in PWAR were predictive of final healing at 16 weeks. Specifically, wounds that reached >= 15% PWAR at 1 week or >= 60% PWAR at 4 weeks had a 68 and 77% (respectively) probability of healing vs. a 31 and 30% probability if these wound area reductions were not achieved. Patients receiving NPWT were 2.5 times more likely to achieve both a >= 15% PWAR at 1 week and a 60% area reduction at 1 month (odds ratios 2.51 and 2.49, respectively) compared with those receiving MWT.
   CONCLUSION - Results of this study suggest that clinicians can calculate: the PWAR of a wound as early as 1 week into treatment to predict the likelihood of healing at 16 weeks. This might also assist in identifying a rationale to reevaluate the wound and change wound therapies.
C1 [Lavery, Lawrence A.] Texas A&M Univ, Scott & White Mem Hosp, Dept Surg, Georgetown, TX 77843 USA.
   [Barnes, Sunni A.; Keith, Michael S.] Kinet Concepts Inc, Hlth Outcomes Res, San Antonio, TX USA.
   [Seaman, John W., Jr.] Baylor Univ, Dept Stat Sci, Waco, TX 76798 USA.
   [Armstrong, David G.] Rosalind Franklin Univ Med & Sci, Dr William M Sch Coll Podiat Med, N Chicago, IL USA.
C3 Texas A&M University System; Scott & White Medical Center; Baylor
   University; Rosalind Franklin University of Medicine & Science
RP Lavery, LA (通讯作者)，Texas A&M Hlth Sci Ctr, Scott & White Georgetown Clin, 703 Highland Spring Ln, Georgetown, TX 78628 USA.
EM lklavery@yahoo.com
OI Lavery, Lawrence/0000-0002-7920-9952
CR [Anonymous], 1999, WINBUGS VERSION 1 2
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Attinger CE, 2006, PLAST RECONSTR SURG, V117, p72S, DOI 10.1097/01.prs.0000225470.42514.8f
   Brown G S, 2000, Adv Skin Wound Care, V13, P277
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   Margolis DJ, 2003, AM J MED, V115, P627, DOI 10.1016/j.amjmed.2003.06.006
   Margolis DJ, 2002, DIABETES CARE, V25, P1835, DOI 10.2337/diacare.25.10.1835
   MCCALLON KS, 2000, OSTOMY WOUND MANAG, V46, P28
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   van Rijswijk L, 1994, Ostomy Wound Manage, V40, P40
   VANRIJSWIJK L, 1993, J FAM PRACTICE, V36, P625
NR 12
TC 112
Z9 121
U1 1
U2 19
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD JAN
PY 2008
VL 31
IS 1
BP 26
EP 29
DI 10.2337/dc07-1300
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 248TQ
UT WOS:000252178900006
PM 17934156
OA Bronze
DA 2026-07-24
ER
PT J
AU Friedrich, JB
   Petrov, RV
   Askay, SAW
   Clark, MP
   Foy, HA
   Isik, FF
   Dellinger, EP
   Klein, MB
   Engrav, LH
AF Friedrich, Jeffrey B.
   Petrov, Roman V.
   Askay, Shelley A. Wiechman
   Clark, Molly P.
   Foy, Hugh A.
   Isik, F. Frank
   Dellinger, E. Patchen
   Klein, Matthew B.
   Engrav, Loren H.
TI Resection of panniculus morbidus: A salvage procedure with a steep
   learning curve
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID ABDOMINOPLASTY; ADJUVANT; SURGERY
AB Background: A subset of obese people develop a pannus hanging to the floor. This panniculus morbidus prevents weight loss, as the patient cannot exercise. It prevents hygiene, leading to a profound odor and ultimately results in intertrigo, cellulitis, and/or abdominal ulceration. The only two options are to live/die with it or resect it. Some of these people are otherwise ready for a weight loss program. For this group, resection of the panniculus morbidus may be indicated. The authors reviewed the literature and found the condition has not been addressed in this journal since 1994 and was not considered in the recent supplement on body contouring. In 1998, the authors began resecting panniculus morbidus for this small group. The authors found the learning curve to be profoundly steep, with many wound complications, a finding that is quite in conflict with the literature on the subject, and decided to present their experience.
   Methods: The authors conducted a retrospective chart review of 23 patients and collected data on demographics, ambulation, hygiene, technique, complications, and outcome.
   Results: The technique of closure evolved as the authors struggled with complications. The current method of closure is three suture layers over four suction drains with a small wound vacuum-assisted closure device at each end of the incision. All patients ultimately healed and found it easier to ambulate and perform hygiene.
   Conclusion: Resection of panniculus morbidus is a beneficial salvage procedure for some morbidly obese people, but the learning curve is steep and the current literature is misleading.
C1 [Friedrich, Jeffrey B.; Petrov, Roman V.; Askay, Shelley A. Wiechman; Clark, Molly P.; Foy, Hugh A.; Isik, F. Frank; Dellinger, E. Patchen; Klein, Matthew B.; Engrav, Loren H.] Univ Washington, Harborview Med Ctr, Dept Surg, Div Plast Surg, Seattle, WA 98104 USA.
   [Friedrich, Jeffrey B.; Petrov, Roman V.; Askay, Shelley A. Wiechman; Clark, Molly P.; Foy, Hugh A.; Isik, F. Frank; Dellinger, E. Patchen; Klein, Matthew B.; Engrav, Loren H.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA.
   [Friedrich, Jeffrey B.; Petrov, Roman V.; Askay, Shelley A. Wiechman; Clark, Molly P.; Foy, Hugh A.; Isik, F. Frank; Dellinger, E. Patchen; Klein, Matthew B.; Engrav, Loren H.] Harborview Med Ctr, Dept Hosp & Nutr, Seattle, WA USA.
C3 University of Washington; University of Washington Seattle; Harborview
   Medical Center; University of Washington; University of Washington
   Seattle; Harborview Medical Center
RP Engrav, LH (通讯作者)，Univ Washington, Harborview Med Ctr, Dept Surg, Div Plast Surg, Box 359796,325 9th Ave, Seattle, WA 98104 USA.
EM engrav@u.washington.edu
RI Petrov, Roman/GXV-4075-2022; Dellinger, E./AFZ-2144-2022
OI Friedrich, Jeffrey/0000-0002-5245-9708
CR Acarturk TG, 2004, ANN PLAS SURG, V53, P360, DOI 10.1097/01.sap.0000135139.33683.2f
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NR 25
TC 19
Z9 22
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2008
VL 121
IS 1
BP 108
EP 114
DI 10.1097/01.prs.0000293760.41152.29
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 249DZ
UT WOS:000252208700015
PM 18176212
DA 2026-07-24
ER
PT J
AU Simek, M
   Nemec, P
   Zalesak, B
   Hajek, R
   Kalab, M
   Jecminkova, L
AF Simek, M.
   Nemec, P.
   Zalesak, B.
   Hajek, R.
   Kalab, M.
   Jecminkova, L.
TI Negative pressure therapy as a treatment modality for surgical site
   infection in cardiac surgery
SO ACTA CHIRURGICA BELGICA
LA English
DT Article; Proceedings Paper
CT 9th Annual Conference of the European-Society-of-Surgery
CY NOV 12, 2005
CL Vienna, AUSTRIA
SP European Soc Surg
DE vacuum assisted closure; cardiac surgery; sternal infection;
   mediastinitis
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND-INFECTION; POSTSTERNOTOMY
   MEDIASTINITIS; POSTOPERATIVE MEDIASTINITIS; RISK-FACTORS; MICROBIOLOGY;
   MANAGEMENT; DRAINAGE
AB Background : Negative pressure therapy (NPT), primarily introduced for the treatment of pressure ulcers or chronic debilitating wounds, has recently emerged as a novel treatment strategy in the field of cardiac surgery, providing superior results to the conventional therapeutic strategies.
   Patients and methods : From November 2004 to October 2005, 25 patients underwent NPT (negative pressure therapy). Four patients (16%) were treated for extensive leg-wound infections, 10 (40%) were treated for superficial sternal wound infections and 11 (44%) for deep sternal wound infections. The median age was 67.9 years (range 48 to 79) and the median BMI was 34.2 kg/M-2 (range 28 to 41). Because of wound infection complications, 11 patients (44%) were re-admitted to the department. In 13 patients (52%), NPT was employed after the failure of the conventional treatment strategy.
   Results : All 25 patients were successfully healed. In-hospital mortality was 0% and 30-day survival was 100%. The overall length of hospitalization reached 36.4 days (range I I to 62). The median number of dressing changes was 4.9 (range 3 to 9). The median NPT treatment time until the surgical closure was 9.7 days (range 6 to 24 days). In 17 patients (68%), the excessive residual sternal defect required a local advancement flap transfer. One patient (4%) with a chronic wire-related fistula was re-admitted 6 months after NPT therapy.
   Conclusion : NPT therapy can be considered as an effective treatment strategy associated with a low risk of procedure failure and wound infection recurrence, particularly in the management of sternal wound infection after cardiac surgery.
C1 [Simek, M.; Nemec, P.; Hajek, R.; Kalab, M.; Jecminkova, L.] Univ Hosp, Dept Cardiac Surg, Olomouc 77520, Czech Republic.
   [Zalesak, B.] Univ Hosp, Dept Plast & Aesthet Surg, Olomouc 77520, Czech Republic.
   [Simek, M.; Nemec, P.; Zalesak, B.; Hajek, R.; Kalab, M.; Jecminkova, L.] Palacky Univ, Fac Med, CR-77147 Olomouc, Czech Republic.
C3 University Hospital Olomouc; University Hospital Olomouc; Palacky
   University Olomouc
RP Simek, M (通讯作者)，Univ Hosp, Dept Cardiac Surg, I P Pavlova 6, Olomouc 77520, Czech Republic.
EM martin.simek@c-mail.cz
RI Hajek, Roman/I-6639-2017
OI Hajek, Roman/0000-0001-6955-6267; Šimek, Martin/0000-0001-5377-2096
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Ascherman JA, 2004, PLAST RECONSTR SURG, V114, P676, DOI 10.1097/01.PRS.0000130939.32238.3B
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   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
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NR 25
TC 2
Z9 3
U1 0
U2 6
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD NOV-DEC
PY 2007
VL 107
IS 6
BP 653
EP 657
DI 10.1080/00015458.2007.11680141
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 250NR
UT WOS:000252307800010
PM 18274179
DA 2026-07-24
ER
PT J
AU Boulanger, K
   Lemaire, V
   Jacquenfin, D
AF Boulanger, K.
   Lemaire, V.
   Jacquenfin, D.
TI Vacuum-assisted closure of enterocutaneous fistula
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE vacuum-assisted closure; enterocutaneous fistula
ID MANAGEMENT; SYSTEM
AB The authors report their experience in the treatment of a posttraumatic enterocutaneous fistula with negative-pressure therapy. After sustaining an epigastric shot wound, a 33-year-old woman underwent three consecutive laparotomies, which eventually led to an open abdomen with the interposition of a surgical mesh. Enterocutaneous fistulae were subsequently documented and Vacuum-Assisted Closure therapy was instituted along with total parenteral nutrition and systemic antibiotics. Development of a suitable granulation bed and closure of the fistulae were noted after two weeks of treatment and a split-thickness skin graft was applied to the wound. Follow-up at 8 months showed stable coverage and a return to normal enteral feeding.
C1 [Boulanger, K.; Lemaire, V.; Jacquenfin, D.] Univ Hosp Liege, Dept Plast & Reconstruct Surg, B-4000 Liege, Belgium.
C3 University of Liege
RP Boulanger, K (通讯作者)，Univ Hosp Liege, Dept Plast & Reconstruct Surg, Sart Tilman 1B, B-4000 Liege, Belgium.
RI /C-7389-2009
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   BRANDT CP, 1995, SURGERY, V118, P736, DOI 10.1016/S0039-6060(05)80043-1
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   Dosluoglu HH, 2005, J VASC SURG, V42, P989, DOI 10.1016/j.jvs.2005.07.006
   Erdmann D, 2001, PLAST RECONSTR SURG, V108, P2066, DOI 10.1097/00006534-200112000-00036
   Falconi M, 2002, GUT S4, V49, piv2
   Gunn LA, 2006, ANN PLAS SURG, V57, P621, DOI 10.1097/01.sap.0000228966.13979.1c
   Heller L, 2006, AM J SURG, V191, P165, DOI 10.1016/j.amjsurg.2005.09.003
   Hyon SH, 2000, ASAIO J, V46, P511, DOI 10.1097/00002480-200007000-00028
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NR 14
TC 13
Z9 15
U1 0
U2 1
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD NOV-DEC
PY 2007
VL 107
IS 6
BP 703
EP 705
DI 10.1080/00015458.2007.11680153
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 250NR
UT WOS:000252307800022
PM 18274191
DA 2026-07-24
ER
PT J
AU Körber, A
   Franckson, T
   Grabbe, S
   Dissemond, J
AF Koerber, A.
   Franckson, T.
   Grabbe, S.
   Dissemond, J.
TI Vacuum assisted closure device improves the take of mesh grafts in
   chronic leg ulcer patients
SO DERMATOLOGY
LA English
DT Article
DE vacuum assisted closure; mesh graft; chronic leg ulcer
AB Background: Vacuum assisted closure (VAC) is established in the management of acute and chronic wounds. In recent years, few data have been published concerning VAC therapy after skin graft transplantation. Objectives: The aim of this study was to determine whether postoperative VAC helps assist closure of mesh grafts in chronic leg ulcer patients. Patients/Methods: We report a consecutive case series of 54 patients with chronic leg ulcers who received a total of 74 mesh grafts. A postoperative VAC therapy was performed in 28 mesh grafts, and 46 mesh grafts were treated with standard gauze therapy. Results: In the VAC group, 92.9% of grafts showed complete healing, compared to 67.4% in the control group without postoperative VAC therapy. Differential analysis revealed a negative correlation of the take rate in patients over 70 years of age or in patients suffering from diabetes mellitus or dermatoliposclerosis. Particularly patients with diabetes mellitus and of greater age exhibited improved take rates, both 100%, in the VAC group compared to 50 and 62%, respectively. Conclusion: The results of our retrospective study demonstrate for the first time the significant benefit of VAC therapy after skin grafting in chronic leg ulcer patients as evaluated in a clinical trial. Copyright (c) 2008 S. Karger AG, Basel.
C1 [Koerber, A.; Franckson, T.; Grabbe, S.; Dissemond, J.] Essen Univ Sch Med, Dept Dermatol, Essen, Germany.
C3 University of Duisburg Essen
RP Dissemond, J (通讯作者)，Univ Sch Med, Dept Dermatol, Hufelandstr 55, DE-45122 Essen, Germany.
EM joachimdissemond@hotmail.com
RI Dissemond, Joachim/AFG-0691-2022; Grabe, Stephan/AAJ-4578-2021
CR Ahnlide I, 2000, ACTA DERM-VENEREOL, V80, P28
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NR 42
TC 51
Z9 58
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-8665
EI 1421-9832
J9 DERMATOLOGY
JI Dermatology
PY 2008
VL 216
IS 3
BP 250
EP 256
DI 10.1159/000112937
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 254ML
UT WOS:000252590600014
PM 18204263
DA 2026-07-24
ER
PT J
AU Durmishi, Y
   Gervaz, P
   Bühler, L
   Bucher, P
   Zufferey, G
   Al-Mazrouei, A
   Morel, P
AF Durmishi, Y.
   Gervaz, P.
   Buehler, L.
   Bucher, P.
   Zufferey, G.
   Al-Mazrouei, A.
   Morel, Ph.
TI Vacuum-assisted abdominal closure:: its role in the treatment of complex
   abdominal and perineal wounds
SO JOURNAL DE CHIRURGIE
LA French
DT Article
DE treatment; adominal wall; VAC; Fournier's gangrene; open abdomen.
ID OPEN ABDOMEN; COMPARTMENT SYNDROME; FASCIAL CLOSURE; EXPERIENCE;
   GANGRENE; TRAUMA
AB Introduction: Vacuum-assisted closure (VAC) is a promising approach for the management of complex abdominal and perineal wounds. This paper summarizes our experience with this therapeutic modality and demonstrates its efficacity in difficult situations.
   Patients and methods: From January 2003 until December 2005, 48 patients (age 30-89) were treated with VAC therapy for open abdomen, infected laparotomy wounds, or tissue loss due to debridement of Fournier's gangrene. Wound dressings were changed every 2-3 days.
   Results: Thirty eight patients (79%) had major co-morbid conditions liable to impact negatively on wound healing. The treatment duration with VAC varied from 20-30 days with an average of eleven dressing changes (minimum 3-maximum 18). Treatment was effective in all patients. Spontaneous closure was achieved in 36 cases (75%); nine patients (19%) required a split-thickness skin graft, and three (6%) underwent delayed secondary closure. Conclusion: In our institution, VAC has become the treatment of choice for complex abdominal and perineal wounds. It is a safe, simple, and effective technique to speed wound healing and it has reduced the duration of hospital treatment in difficult clinical situations and in patients whose general condition is often severely compromised.
C1 [Durmishi, Y.; Gervaz, P.; Buehler, L.; Bucher, P.; Zufferey, G.; Al-Mazrouei, A.; Morel, Ph.] Hop Cantonal Univ Geneva, Dept Chirurg, CH-1211 Geneva, Switzerland.
C3 University of Geneva
RP Durmishi, Y (通讯作者)，Hop Cantonal Univ Geneva, Dept Chirurg, 24 Rue Micheli du Crest, CH-1211 Geneva, Switzerland.
EM ymer.durmishi@hcuge.ch
OI Buhler, Leo/0000-0002-9461-8498
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   TEOT L, 2004, J PLAIES CICATRISATI
NR 16
TC 12
Z9 15
U1 0
U2 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0021-7697
J9 J CHIR-PARIS
JI J. Chir.
PD MAY-JUN
PY 2007
VL 144
IS 3
BP 209
EP 213
DI 10.1016/S0021-7697(07)89516-0
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 254PU
UT WOS:000252600200005
PM 17925713
DA 2026-07-24
ER
PT J
AU Kanakaris, NK
   Thanasas, C
   Keramaris, N
   Kontakis, G
   Granick, MS
   Giannoudis, PV
AF Kanakaris, N. K.
   Thanasas, C.
   Keramaris, N.
   Kontakis, G.
   Granick, M. S.
   Giannoudis, P. V.
TI The efficacy of negative pressure wound therapy in the management of
   lower extremity trauma: Review of clinical evidence
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE negative pressure wound therapy (NPWT); vacuum-assisted wound closure
   (VAC (R)); wound heating; trauma; burns; review
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; TIBIAL SHAFT FRACTURES;
   SUBATMOSPHERIC PRESSURE; TEMPORARY TREATMENT; SKIN-GRAFTS; EXPERIENCE;
   RECONSTRUCTION; PROGRESSION; CHILDREN
AB A large number of aids have been conceived and introduced into clinical practice (nutritional supplements, local dressings, technical innovations) aimed at facilitating and optimising wound heating in both acute and chronic wound settings.
   Among these advances, negative pressure wound therapy (NPWT) has been introduced during the last 30 years, and has been analysed in over 400 manuscripts of the English, Russian and German literature. Until very recently, vacuum assisted closure (VAC(R)) (KCI, TX, USA) has been the only readily available commercial device that provides locatised negative pressure to the wound and is the predominant agent used to deliver NPWT featured in this review.
   We conducted a comprehensive review of the existing clinical evidence of the English literature on the apptications of NPWT in the acute setting of trauma and burns of the lower extremity. Overall, 16 clinical studies have been evaluated and scrutinised as to the safety and the efficacy of this adjunct therapy in the specific environment of trauma.
   Effectiveness was comparable to the standard dressing and wound coverage methods. The existing clinical evidence justifies its application in Lower limb injuries associated with soft tissue trauma. (C) 2007 Elsevier Ltd. All rights reserved.
C1 [Kanakaris, N. K.; Thanasas, C.; Keramaris, N.; Giannoudis, P. V.] Univ Leeds, Teaching Hosp, Acad Dept Trauma & Orthopaed, Leeds LS1 3EX, W Yorkshire, England.
   [Granick, M. S.] Univ Med & Dent New Jersey, Sch Med, Dept Plast Surg, Newark, NJ 07103 USA.
C3 University of Leeds; Rutgers University System; Rutgers University New
   Brunswick; Rutgers University Biomedical & Health Sciences
RP Giannoudis, PV (通讯作者)，Univ Leeds, Teaching Hosp, Acad Dept Trauma & Orthopaed, Great George St, Leeds LS1 3EX, W Yorkshire, England.
EM pgiannoudi@aol.com
RI Giannoudis, Peter/AAA-3617-2020
OI Kanakaris, Nikolaos/0000-0002-1695-1519
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NR 46
TC 89
Z9 106
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD DEC
PY 2007
VL 38
SU 5
BP S9
EP S18
DI 10.1016/j.injury.2007.10.029
PG 10
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 258FZ
UT WOS:000252855100003
PM 18045598
DA 2026-07-24
ER
PT J
AU Gregor, S
   Maegele, M
   Sauerland, S
   Krahn, JF
   Peinemann, F
   Lange, S
AF Gregor, Sven
   Maegele, Marc
   Sauerland, Stefan
   Krahn, Jan F.
   Peinemann, Frank
   Lange, Stefan
TI Negative pressure wound therapy - A vacuum of evidence?
SO ARCHIVES OF SURGERY
LA English
DT Review
ID ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; RANDOMIZED-TRIAL; SURGICAL
   WOUNDS; SKIN-GRAFTS; MANAGEMENT; DRESSINGS
AB Objective: To systematically examine the clinical effectiveness and safety of negative pressure wound therapy (NPWT) compared with conventional wound therapy.
   Data Sources: MEDLINE, EMBASE, CINAHL, and the Cochrane Library were searched. Manufacturers were contacted, and trial registries were screened.
   Study Selection: Randomized controlled trials (RCTs) and non-RCTs comparing NPWT and conventional therapy for acute or chronic wounds were included in this review. The main outcomes of interest were wound-healing variables. After screening 255 full-text articles, 17 studies remained. In addition, 19 unpublished trials were found, of which 5 had been prematurely terminated.
   Data Extraction: Two reviewers independently extracted data and assessed methodologic quality in a standardized manner.
   Data Synthesis: Seven RCTs (n=324) and 10 non-RCTs (n=278) met the inclusion criteria. The overall methodologic quality of the trials was poor. Significant differences in favor of NPWT for time to wound closure or incidence of wound closure were shown in 2 of 5 RCTs and 2 of 4 non-RCTs. A meta-analysis of changes in wound size that included 4 RCTs and 2 non-RCTs favored NPWT (standardized mean difference: RCTs, -0.57; non-RCTs, -1.30).
   Conclusions: Although there is some indication that NPWT may improve wound healing, the body of evidence available is insufficient to clearly prove an additional clinical benefit of NPWT. The large number of prematurely terminated and unpublished trials is reason for concern.
C1 [Sauerland, Stefan; Krahn, Jan F.] Univ Witten Herdecke, Inst Res Operat Med, D-51109 Cologne, Germany.
   [Gregor, Sven] Univ Witten Herdecke, Dept Abdominal Vasc & Transplantat Surg, D-51109 Cologne, Germany.
   [Maegele, Marc] Univ Witten Herdecke, Dept Trauma Orthoped Surg, D-51109 Cologne, Germany.
   [Peinemann, Frank; Lange, Stefan] Inst Qual & Efficiency Hlth Care, Cologne, Germany.
   [Gregor, Sven] Reg Hosp Gummersbach, Dept Abdominal Thorac & Vasc Surg, Gummersbach, Germany.
C3 Witten Herdecke University; Witten Herdecke University; Witten Herdecke
   University
RP Sauerland, S (通讯作者)，Univ Witten Herdecke, Inst Res Operat Med, Ostmerheimer Str 200, D-51109 Cologne, Germany.
EM Stefan.Sauerland@ifom-uni-wh.de
RI /H-2800-2019
OI Sauerland, Stefan/0000-0003-1048-796X
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NR 52
TC 139
Z9 159
U1 0
U2 26
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0004-0010
EI 1538-3644
J9 ARCH SURG-CHICAGO
JI Arch. Surg.
PD FEB
PY 2008
VL 143
IS 2
BP 189
EP 196
DI 10.1001/archsurg.2007.54
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 259GG
UT WOS:000252927200019
PM 18283145
DA 2026-07-24
ER
PT J
AU Mokhtari, A
   Sjögren, J
   Nilsson, J
   Gustafsson, R
   Malmsjö, M
   Ingemansson, R
AF Mokhtari, Arash
   Sjogren, Johan
   Nilsson, Johan
   Gustafsson, Ronny
   Malmsjo, Malin
   Ingemansson, Richard
TI The cost of vacuum-assisted closure therapy in treatment of deep sternal
   wound infection
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE health economics; health policy; mediastinitis; wound closure; CABG;
   sternum
ID BYPASS GRAFT-SURGERY; LONG-TERM SURVIVAL; CARDIAC-SURGERY;
   POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS; COMPLICATIONS; SYSTEM;
   IMPACT
AB Objectives. Surgical sites infections are very expensive and the total costs for coronary artery bypass grafting (CABG) surgery followed by deep sternal wound infection (DSWI) with conventional therapy are estimated to be 2.8 times that for normal, CABG surgery. Promising results have been reported with vacuum-assisted closure (VAC) therapy in patients with DSWI. This study presents the cost of VAC therapy in patients with DSWI after CABG surgery. Design. Thirty-eight CABG patients with DSWI, between 2001 and 2005, were treated with VAC therapy. The cost of surgery, intensive care, ward care, laboratory tests and other costs were analyzed. Results. No three-month mortality or recurrent infection was observed. The average cost of CABG procedure and treatment of DSWI was 2.5 times higher than the mean cost of CABG alone. No significant correlations were found between the preoperative EuroSCORE and the cost of DSWI therapy. Conclusions. VAC therapy for patients who underwent CABG surgery followed by DSWI seems to be cost effective, and has low mortality rate.
C1 [Mokhtari, Arash; Sjogren, Johan; Nilsson, Johan; Gustafsson, Ronny; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Malmsjo, Malin] Univ Lund Hosp, Dept Internal Med, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Mokhtari, A (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, SE-22185 Lund, Sweden.
EM arash.mokhtari@med.lu.se
RI Sjögren, Johan/AAZ-6448-2021; Nilsson, Johan/A-4742-2011
OI Maljö, Malin/0000-0001-9849-9599; Nilsson, Johan/0000-0001-6860-6090;
   Ingemansson, Richard/0000-0001-7623-8953
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NR 21
TC 36
Z9 41
U1 0
U2 2
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 1401-7431
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2008
VL 42
IS 1
BP 85
EP 89
DI 10.1080/14017430701744469
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 262BB
UT WOS:000253122900011
PM 18273735
OA Bronze
DA 2026-07-24
ER
PT J
AU Brem, MH
   Blanke, M
   Olk, A
   Schmidt, J
   Mueller, O
   Hennig, FF
   Gusinde, J
AF Brem, M. H.
   Blanke, M.
   Olk, A.
   Schmidt, J.
   Mueller, O.
   Hennig, F. F.
   Gusinde, J.
TI The vacuum-assisted closure (VAC) and instillation dressing.: Limb
   salvage after 3° open fracture with massive bone and soft tissue defect
   and superinfection
SO UNFALLCHIRURG
LA German
DT Article
DE vacuum-assisted closure; trauma; fracture; tissue defect; wound healing
ID NEGATIVE-PRESSURE; MANAGEMENT; INJURIES; THERAPY
AB We report the case of a 17-year-old boy who was hit by a high velocity train. The polytraumatized patient suffered a 3 degrees open femur defect fracture with a substantial loss of the lateral femoral muscles and significant disruption of the soft tissue of the lower leg. The enormous wound areas on the thigh and the lower leg were infected by Pseudomonas aeruginosa, Enterobacter cloacae, and Stenotrophomonas maltophilia. The enormous tissue defects and the superinfection did not leave any hope for saving the limb from amputation. After rapid aggressive debridement and pulsatile lavage, we covered the wounds as a last resort with a new technique of vacuum-assisted closure (V.A.C) and instillation (V.A.C. Instill((R))) dressings. In sequences of 1 min we instilled Lavasept, kept it for 20 min on the wound surface, and exhausted the liquid. We repeated this for 6 consecutive days and then changed the dressing. In the follow-up examinations the number of germs was significantly reduced. During follow-up care we used the V.A.C. treatment without instillation and finally we transplanted skin onto the clean wound surface and were able to save the leg of this young patient. We discharged him with a good function of his lower leg. This technique of V.A.C. Instill seems to offer great possibilities in critically infected wound situations.
C1 [Brem, M. H.; Blanke, M.; Olk, A.; Mueller, O.; Hennig, F. F.; Gusinde, J.] Univ Klinikum, Chirurg Klin, Abt Unfallchirurg, D-91054 Erlangen, Germany.
   [Schmidt, J.] Univ Klinikum Erlangen, Anasthesiol Klin, Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Brem, MH (通讯作者)，Univ Klinikum, Chirurg Klin, Abt Unfallchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM matthias.brem@chir.imed.uni-erlangen.de
RI /I-3462-2012
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   WILLY C, 2005, VAKUUMTHERAPIE
NR 13
TC 20
Z9 22
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD FEB
PY 2008
VL 111
IS 2
BP 122
EP 125
DI 10.1007/s00113-007-1360-1
PG 4
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 263BG
UT WOS:000253192000009
PM 18219474
DA 2026-07-24
ER
PT J
AU Shapiro, SB
   Mumme, DE
AF Shapiro, Stephen B.
   Mumme, Daniel E.
TI Use of negative pressure wound therapy in the management of wound
   dehiscence in a pregnant patient
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID OBSTRUCTION
C1 [Shapiro, Stephen B.] Gundersen Lutheran Hlth Syst, Dept Gen Surg, La Crosse, WI USA.
   [Mumme, Daniel E.] Gundersen Lutheran Med Fdn, Dept Res, La Crosse, WI USA.
C3 Gundersen Lutheran Medical Center
RP Shapiro, SB (通讯作者)，Gundersen Lutheran Hlth Syst, Dept Surg, 1900 S Ave, La Crosse, WI 54601 USA.
EM sbshapir@gundluth.org
CR Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
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NR 5
TC 3
Z9 3
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2008
VL 20
IS 2
BP 46
EP 48
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 266JF
UT WOS:000253430400006
PM 25941964
DA 2026-07-24
ER
PT J
AU Kumar, P
AF Kumar, Pramod
TI Limited access dressing
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; OCCLUSIVE DRESSINGS;
   WOUND CONTROL; SKIN-GRAFTS; THERAPY; GROWTH; TRIAL; FLORA
C1 [Kumar, Pramod] Kasturba Med Coll & Hosp, Dept Plast Surg, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Kasturba Medical College,
   Manipal
RP Kumar, P (通讯作者)，Kasturba Med Coll & Hosp, Dept Plast Surg, Manipal 576104, Karnataka, India.
EM pkumar86@hotmail.com
RI Kumar, Pramod/L-8280-2015
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NR 45
TC 10
Z9 11
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2008
VL 20
IS 2
BP 49
EP 59
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 266JF
UT WOS:000253430400007
PM 25941965
DA 2026-07-24
ER
PT J
AU DeFranzo, AJ
   Pitzer, K
   Molnar, JA
   Marks, MW
   Chang, MC
   Miller, PR
   Letton, RW
   Argenta, LC
AF DeFranzo, Anthony J.
   Pitzer, Keith
   Molnar, Joseph A.
   Marks, Malcolm W.
   Chang, Michael C.
   Miller, Preston R.
   Letton, Robert W.
   Argenta, Louis C.
TI Vacuum-assisted closure for defects of the abdominal wall
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 73rd Annual Meeting of the American-Society-of-Plastic-Surgeons
CY OCT   17, 2004
CL Philadelphia, PA
SP Amer Soc Plast Surg
ID INJURED PATIENTS; RECONSTRUCTION; FLAP
AB Background: Reconstruction of the abdominal wall poses a problem common to many surgical specialties: Abdominal wall defects may be caused by trauma and/or prior surgery, with dehiscence or infection. Several options to repair the structural integrity of the abdominal wall exist, including primary closure, flaps, mesh, and skin grafts. Complications of these procedures include recurrent infection of the abdominal wall, infection of mesh, dehiscence, flap death, and poor skin graft take. Risk factors predisposing to these complications include tissue edema, preoperative tissue infection, and patient debilitation, with poor wound healing potential. Ideally, reconstruction should be performed on a nonedematous, clean tissue bed with bacterial levels less than 10(5) bacteria/cm(3) in a well-nourished patient.
   Methods: Vacuum-assisted closure was used in a series of patients in an attempt to prepare the abdominal wall for reconstruction and reduce the risk of complications. Charts were reviewed for 100 patients who underwent abdominal wall reconstruction after vacuum-assisted closure therapy. Their wound cause, reconstruction technique, complications, and number of days on the vacuum-assisted closure device are reported.
   Results: The ability of vacuum-assisted closure to reduce edema, increase blood flow, potentially decrease bacterial colonization, and reduce wound size greatly facilitated abdominal wall reconstruction. The vacuum-assisted closure device served as a temporary dressing with which to control dehiscence and to maintain abdominal wall integrity when bowel wall edema prevented abdominal closure.
   Conclusion: Vacuum-assisted closure therapy frequently shortened time to abdominal wall reconstruction and simplified the method of reconstruction.
C1 [DeFranzo, Anthony J.] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
   Wake Forest Univ, Bowman Gray Sch Med, Dept Gen Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University; Wake Forest Baptist Medical Center
RP DeFranzo, AJ (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM adefranz@wfubmc.edu
RI Molnar, Joseph/AEK-5540-2022
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NR 18
TC 36
Z9 49
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAR
PY 2008
VL 121
IS 3
BP 832
EP 839
DI 10.1097/01.prs.0000299268.51008.47
PG 8
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 268GA
UT WOS:000253566000013
PM 18317132
DA 2026-07-24
ER
PT J
AU Tarkin, IS
   Clare, MP
   Marcantonio, A
   Pape, HC
AF Tarkin, I. S.
   Clare, M. P.
   Marcantonio, A.
   Pape, H. C.
TI An update on the management of high-energy plion fractures
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE piton fracture; plafond fracture; distal tibia fracture; biological
   plating; vacuum assisted; closure device
ID TIBIAL PILON FRACTURES; VACUUM-ASSISTED CLOSURE; INTERNAL-FIXATION;
   EXTERNAL FIXATION; PLAFOND FRACTURES; OPEN REDUCTION; DISTAL TIBIA;
   INTRAARTICULAR FRACTURE; ARTICULAR-CARTILAGE; TREATMENT PROTOCOL
AB High energy piton fractures present a unique challenge to the patient and orthopaedic surgeon. Care for the soft tissue envelope is as important as management of this articular fracture. This article reviews the fundamental principles for treatment of the patient with severe piton fracture. Staged operative care is emphasised to prevent wound and infectious complications which have historically plagued piton fracture surgery. New innovations directed at improving results are discussed including biological planting and wound care using the vacuum assisted closure device. Lastly, validated outcomes are presented which highlight the severity of these injuries despite optimal care. (c) 2007 Elsevier Ltd. All rights reserved.
C1 [Tarkin, I. S.; Marcantonio, A.; Pape, H. C.] Univ Pittsburgh, Med Ctr, Div Orthopaed Traumatol, Pittsburgh, PA 15213 USA.
   [Clare, M. P.] Florida Orthopaed Inst, Div Foot & Ankle Surg, Tampa, FL USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Florida Orthopaedic Institute
RP Tarkin, IS (通讯作者)，Univ Pittsburgh, Med Ctr, Div Orthopaed Traumatol, 3471 5th Ave, Pittsburgh, PA 15213 USA.
EM tarkinis@upmc.edu
OI Pape, Hans-Christoph/0000-0002-2059-4980
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   [No title captured]
NR 57
TC 76
Z9 102
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2008
VL 39
IS 2
BP 142
EP 154
DI 10.1016/j.injury.2007.07.024
PG 13
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 268UV
UT WOS:000253606200001
PM 18054017
DA 2026-07-24
ER
PT J
AU Potter, MJ
   Banwell, P
   Baldwin, C
   Clayton, E
   Irvine, L
   Linge, C
   Grobbelaar, AO
   Sanders, R
   Dye, JF
AF Potter, Matthew J.
   Banwell, Paul
   Baldwin, Christopher
   Clayton, Elizabeth
   Irvine, Laurie
   Linge, Claire
   Grobbelaar, Addrian O.
   Sanders, Roy
   Dye, Julian F.
TI In vitro optimisation of topical negative pressure regimens for
   angiogenesis into synthetic dermal replacements
SO BURNS
LA English
DT Article
DE topical negative pressure; angiogenesis; synthetic dermal replacements
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTIVE SURGERY; ARTIFICIAL SKIN; TISSUE
   DEFECTS; WOUND CONTROL; MATRIX; ALLOGRAFT; INTEGRA; FIBROBLASTS;
   EXPERIENCE
AB Background: The use of synthetic dermal replacements (SDRs) in the treatment of large wounds, which have associated morbidity and mortality, has attracted great interest. However, because of poor outcome, SDRs have limited use. The addition of topical negative pressure (TNP) has increased their success, but little research has focused on the underlying mechanisms. This paper studies the in vitro effects of TNP on commonly used SDRs to identify the most effective TNP regimen and optimum SDR for encouraging endothelial cell ingress.
   Methods: Endothelial cells were co-cultured in vitro on four SDRs with or without TNP. Negative pressure (125 mmHg) was applied intermittently, continuously, for 4 h per day, or not at all. Endothelial ingress was measured for each condition.
   Results: In the collagen controls, cell migration was minimal. Integra (TM) gave the greatest endothelial cell migration (p < 0.05, n = 3). TNP increased endothelial cell migration, intermittent application being the optimum regimen.
   Conclusions: Integra (TM) has an open sponge structure which may account for greater angiogenicity than Alloderm (TM), Permacol (TM) and Xenoder (TM). In vitro intermittent TNP stimulates the greatest angiogenic response. The majority of clinical studies investigating SDR success with TNP have used continuous regimens; this study suggests a change in clinical practice to intermittent application. (c) 2007 Elsevier Ltd and ISBI. All rights reserved.
C1 [Potter, Matthew J.; Baldwin, Christopher; Clayton, Elizabeth; Linge, Claire; Grobbelaar, Addrian O.; Sanders, Roy; Dye, Julian F.] Mt Vernon Hosp, RAFT Inst, Northwood HA6 2RN, Middx, England.
   [Banwell, Paul] Salisbury Dist Gen Hosp, Odstock Burns & Wound Healing Charitable Trust, Salisbury, Wilts, England.
   [Irvine, Laurie] Watford Hosp, NHS Trust, Dept Obstet & Gynaecol, Watford, England.
C3 Salisbury District Hospital; Watford General Hospital
RP Potter, MJ (通讯作者)，43 Queen St, Eynsham OX29 4HH, England.
EM Mattpotters@hotmail.com
RI Dye, Julian Francis/U-3396-2019; Potter, Matthew/JFK-2500-2023;
   Grobbelaar, Adriaan/IUQ-0370-2023
OI Dye, Julian Francis/0000-0001-7634-2822; Grobbelaar,
   Adriaan/0000-0003-2001-5173
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NR 45
TC 25
Z9 32
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAR
PY 2008
VL 34
IS 2
BP 164
EP 174
DI 10.1016/j.burns.2007.06.020
PG 11
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 270DZ
UT WOS:000253701600002
PM 18242874
DA 2026-07-24
ER
PT J
AU Canavese, F
   Gupta, S
   Krajbich, JI
   Emara, KM
AF Canavese, F.
   Gupta, S.
   Krajbich, J. I.
   Emara, K. M.
TI Vacuum-assisted closure for deep infection after spinal instrumentation
   for scoliosis
SO JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
LA English
DT Article
ID SOFT-TISSUE DEFECTS; WOUND INFECTIONS; MANAGEMENT; FUSION; ADULTS
AB Our aim was to review the efficacy of the wound vacuum-assisted closure (VAC) system in the treatment of deep infection after extensive instrumentation and fusion for spinal deformity in children and adolescents.
   A total of 14 patients with early deep spinal infection were treated using this technique. Of these, 12 had neuromuscular or syndromic problems. Clinical and laboratory data were reviewed. The mean follow-up was 44 months (24 to 72). All wounds healed. Two patients required plastic surgery to speed up the process. In no patient was the hardware removed and there was no loss of correction or recurrent infection.
   We believe that the wound VAC system is a useful tool in the armamentarium of the spinal surgeon dealing with patients susceptible to wound infections, especially those with neuromuscular diseases. It allows for the retention of the instrumentation and the maintenance of spinal correction. It is reliable and easy to use.
C1 [Canavese, F.; Gupta, S.; Krajbich, J. I.] Shriners Hosp Children, Dept Pediat Orthopaed, Portland, OR 97237 USA.
RP Canavese, F (通讯作者)，Shriners Hosp Children, Dept Pediat Orthopaed, 3101 SW Sam Jackson Pk Rd, Portland, OR 97237 USA.
EM canavese_federico@yahoo.fr
RI ; Emara, Khaled/Q-1008-2019; Gupta, Subhas/C-5458-2018
OI CANAVESE, Federico/0000-0002-6114-5372; Emara,
   Khaled/0000-0001-7060-0325; Gupta, Subhas/0000-0001-5091-3922
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NR 18
TC 53
Z9 66
U1 0
U2 1
PU BRITISH EDITORIAL SOC BONE JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 0301-620X
J9 J BONE JOINT SURG BR
JI J. Bone Joint Surg.-Br. Vol.
PD MAR
PY 2008
VL 90B
IS 3
BP 377
EP 381
DI 10.1302/0301-620X.90B3.19890
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 271FR
UT WOS:000253774800021
PM 18310764
OA Bronze
DA 2026-07-24
ER
PT J
AU Murray, CK
   Hsu, JR
   Solomkin, JS
   Keeling, JJ
   Andersen, RC
   Ficke, JR
   Calhoun, JH
AF Murray, Clinton K.
   Hsu, Joseph R.
   Solomkin, Joseph S.
   Keeling, John J.
   Andersen, Romney C.
   Ficke, James R.
   Calhoun, Jason H.
TI Prevention and management of infections associated with combat-related
   extremity injuries
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Review
DE combat; trauma; extremity; infection
ID OPEN TIBIAL FRACTURES; DELAYED SURGICAL-TREATMENT;
   OPERATION-IRAQI-FREEDOM; HUMERAL SHAFT FRACTURES; PRESSURE WOUND
   THERAPY; EXTERNAL FIXATION; FEMORAL-SHAFT; INTERNAL-FIXATION; DEEP
   INFECTION; WAR WOUNDS
AB Orthopedic injuries suffered by casualties during combat constitute approximately 65% of the total percentage of injuries and are evenly distributed between upper and lower extremities. The high-energy explosive injuries, environmental contamination, varying evacuation procedures, and progressive levels of medical care make managing combat-related injuries challenging. The goals of orthopedic injury management are to prevent infection, promote fracture healing, and restore function. It appears that 2% to 15% of combat-related extremity injuries develop osteomyelitis, although lower extremity injuries are at higher risk of infections than upper extremity. Management strategies of combat-related injuries primarily focus on early surgical debridement and stabilization, antibiotic administration, and delayed primary closure. Herein, we provide evidence-based recommendations from military and civilian data to the management of combat-related injuries of the extremity. Areas of emphasis include the utility of bacterial cultures, antimicrobial therapy, irrigation fluids and techniques, timing of surgical care, fixation, antibiotic impregnated beads, wound closure, and wound coverage with negative pressure wound therapy. Most of the recommendations are not supported by randomized controlled trials or adequate cohorts studies in a military population and further efforts are needed to answer best treatment strategies.
C1 [Murray, Clinton K.; Hsu, Joseph R.; Solomkin, Joseph S.; Keeling, John J.; Andersen, Romney C.; Ficke, James R.; Calhoun, Jason H.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
C3 United States Department of Defense; United States Army; Brooke Army
   Medical Center
RP Murray, CK (通讯作者)，Brooke Army Med Ctr, Infect Dis Serv, 3851 Roger Dr, Ft Sam Houston, TX 78234 USA.
EM Clinton.Murray@amedd.army.mil
OI Solomkin, Joseph/0000-0001-6382-4902; Andersen,
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NR 143
TC 123
Z9 150
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD MAR
PY 2008
VL 64
IS 3
SU S
BP S239
EP S251
DI 10.1097/TA.0b013e318163cd14
PG 13
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 276SY
UT WOS:000254164300005
PM 18316968
DA 2026-07-24
ER
PT J
AU Bhattacharyya, T
   Mehta, P
   Smith, RM
   Pomahac, B
AF Bhattacharyya, Timothy
   Mehta, Priyesh
   Smith, R. Malcolm
   Pomahac, Bohdan
TI Routine use of wound vacuum-assisted closure does not allow coverage
   delay for open tibia fractures
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID SOFT-TISSUE INJURIES; SEVERE COMPOUND FRACTURES; MANAGEMENT; THERAPY;
   RECONSTRUCTION; COMPLICATIONS; FOUNDATION; EXPERIENCE; TRAUMA; TRENDS
AB Background: Prevention of infection is a paramount concern after open fracture of the tibia. Previous studies have shown that delay in soft-tissue coverage may raise infection rates. Use of vacuum-assisted closure devices in open fracture wounds has become common. The authors analyzed whether use of the vacuum-assisted closure sponge can allow delay of flap coverage for open tibia fractures without an increase in infection rate.
   Methods: The authors identified 38 patients with Gustilo grade IIIB open fractures from their trauma registry with a minimum I-year follow-up. From the medical record, the authors collected information on the time from injury to definitive wound coverage, type of fixation, type of coverage, and demographics. Infected patients were defined as patients that required surgical debridement after coverage with positive cultures.
   Results: Patients who underwent definitive coverage within 7 days had a significantly decreased rate of infection (12.5 percent) compared with patients who had coverage at 7 days or more after injury (57 percent) (p < 0.008). The overall infection rate was 36 percent with routine use of the vacuum-assisted closure sponge. Patients who developed infection had a greater mean time to coverage than patients who did not develop infection (8.9 days versus 4.8 days; p < 0.029).
   Conclusions: Routine use of vacuum-assisted closure with open tibia fractures is safe and provides a good primary dressing over open wounds. For Gustilo grade IIIB tibia fractures, vacuum-assisted closure therapy does not allow delay of soft-tissue coverage past 7 days without a concomitant elevation in infection rates.
C1 [Bhattacharyya, Timothy] Brigham & Womens Hosp, Massachusetts Gen Hosp, Partners Orthoped Trauma Serv, Boston, MA 02118 USA.
   Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02118 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Massachusetts General Hospital; Harvard University;
   Harvard University Medical Affiliates; Brigham & Women's Hospital
RP Bhattacharyya, T (通讯作者)，Brigham & Womens Hosp, Massachusetts Gen Hosp, Partners Orthoped Trauma Serv, 55 Fruit St,Yawkey 3600, Boston, MA 02118 USA.
RI Pomahac, Bohdan/AAH-1792-2019
OI Pomahac, Bohdan/0000-0003-3703-8240
CR Alberts KA, 1999, INJURY, V30, P519, DOI 10.1016/S0020-1383(99)00143-6
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NR 25
TC 107
Z9 131
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR
PY 2008
VL 121
IS 4
BP 1263
EP 1266
DI 10.1097/01.prs.0000305536.09242.a6
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 277AA
UT WOS:000254183600023
PM 18349645
DA 2026-07-24
ER
PT J
AU Mees, ST
   Palmes, D
   Mennigen, R
   Senninger, N
   Haier, J
   Bruewer, M
AF Mees, Soeren Torge
   Palmes, Daniel
   Mennigen, Rudolf
   Senninger, Norbert
   Haier, Joerg
   Bruewer, Matthias
TI Endo-vacuum assisted closure treatment for rectal anastomotic
   insufficiency
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE anastomotic leakage; vacuum assisted closure; rectal surgery; wound
   healing
ID RISK-FACTORS; MESORECTAL EXCISION; WOUND CONTROL; RESECTION; DRAINAGE;
   LEAKAGE; CANCER
AB BACKGROUND: Anastomotic insufficiency in patients with colorectal anastomosis is a major complication with high morbidity and mortality. Local treatment with transrectal lavage and drainage can be considered in patient without peritonitis. In order to prevent prolonged wound closure and secondary complications during conservative treatment we investigated the vacuum assisted closure (VAC) in this setting.
   METHODS: Ten patients with anastomotic insufficiency after colorectal resections, who did not require transabdominal interventions, were treated with an Endo-vacuum assisted closure dressing (Group A; n=5) or by transrectal lavage (Group B; n=5). Time for wound healing, duration of hospitalization and pain assessment were compared in both groups.
   RESULTS: The Endo-vacuum assisted closure treatment was performed for a median time of 27 days without any vacuum assisted closure associated complications. Wound healing was significantly accelerated in Group A compared to Group B. Time in hospital was slightly shortened in patients with Endo-vacuum assisted closure. Pain assessment in both groups did not show any significant differences.
   CONCLUSION: Endo-vacuum assisted closure therapy is a novel approach that can be considered in diverted patients with failed colorectal anastomoses. Larger randomized trials that include complete cost-benefit analyses are needed to establish its role in this setting.
C1 [Mees, Soeren Torge; Palmes, Daniel; Mennigen, Rudolf; Senninger, Norbert; Haier, Joerg; Bruewer, Matthias] Univ Hosp Muenster, Dept Gen Surg, D-48149 Munster, Germany.
C3 University of Munster
RP Mees, ST (通讯作者)，Univ Hosp Muenster, Dept Gen Surg, Waldeyerstr 1, D-48149 Munster, Germany.
EM soerentorge.mees@ukmuenster.de
RI Haier, Jörg/JJF-6724-2023
OI Haier, Jörg/0000-0002-1278-9438
CR Anderson ID, 1996, BRIT J SURG, V83, P535, DOI 10.1002/bjs.1800830434
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NR 20
TC 64
Z9 76
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD APR
PY 2008
VL 51
IS 4
BP 404
EP 410
DI 10.1007/s10350-007-9141-z
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 277SP
UT WOS:000254235300008
PM 18197452
DA 2026-07-24
ER
PT J
AU Salazard, B
   Niddam, J
   Ghez, O
   Metras, D
   Magalon, G
AF Salazard, B.
   Niddam, J.
   Ghez, O.
   Metras, D.
   Magalon, G.
TI Vacuum-assisted clsoure in the treatment of poststernotomy mediastinitis
   in the paediatric patient
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article; Proceedings Paper
CT Congress of the French-Society-of-Plastic-Surgery
CY MAR, 2006
CL Brussels, BELGIUM
SP French Soc Plast Surg
DE mediastinitis; negative pressure therapy; sternal dehiscence treatment
ID MUSCLE FLAP; POSTOPERATIVE MEDIASTINITIS; CARDIAC-SURGERY; CLOSURE;
   INFECTION; CHILDREN; INFANT
AB Introduction: Delayed sternal closure after paediatric open heart procedure is often necessary. The risk of delayed sternal closure is infection: superficial wound or sternal and mediastinal infection. The incidence of sternal wound infection reported in the literature varies from 0.5 to 10%. The mortality for poststernotomy deep sternal infection continues to be high - from 14 to 47%. Established treatment includes surgical debridement, drainage and irrigation, antibiotics, frequent change of wound dressing and direct or secondary closure with omentum or pectoral muscle flap.
   Patients and methods: Between October 2003 and August 2005, three children, aged from 9 days to 2 years and who had developed severe mediastinitis after cardiac surgery were treated with the vacuum-assisted closure (VAC) system.
   Results: The duration of VAC treatment ranged from 12 to 21 days. The response to VAC was rapid with local purulence and C.-reactive protein (CRP) both decreasing within 72 h in all cases. After good granulation was obtained, two patients required a thin skin graft.
   Discussion: All three children had peritoneal dialysis which did not permit omental use. The use of pectoralis major is a difficult technique in neonates and the haemodynamic conditions were poor in our cases. The VAC technique is a good indication in post-cardiotomy mediastinitis in children: it plays a role in the reduction of infection and provides good heating. (c) 2007 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Salazard, B.; Niddam, J.; Magalon, G.] Timone Childrens Hosp, Dept Paediat Plast Surg, F-13385 Marseille 05, France.
   [Metras, D.] Timone Childrens Hosp, Dept Paediat Thorac & Cardiac Surg, F-13385 Marseille, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille
RP Salazard, B (通讯作者)，Hop Conception, Serv Pr Magalon, 147 Blvd Baille, F-13385 Marseille 05, France.
EM bruno.salazard@wanadoo.fr
RI /AAF-1639-2019
CR Brandt C, 2002, PLAST RECONSTR SURG, V109, P2231, DOI 10.1097/00006534-200206000-00009
   Erez E, 2000, ANN THORAC SURG, V70, P1449, DOI 10.1016/S0003-4975(00)01869-5
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   Gursel E, 2002, PLAST RECONSTR SURG, V110, P844, DOI 10.1097/01.PRS.0000019917.27798.BE
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Ohye RG, 2004, J THORAC CARDIOV SUR, V128, P480, DOI 10.1016/j.jtcvs.2004.04.023
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   STAHL RS, 1988, PLAST RECONSTR SURG, V82, P1000, DOI 10.1097/00006534-198812000-00010
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NR 11
TC 27
Z9 35
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PY 2008
VL 61
IS 3
BP 302
EP 305
DI 10.1016/j.bjps.2007.05.004
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 278FI
UT WOS:000254269600012
PM 17586108
DA 2026-07-24
ER
PT J
AU Rozen, WM
   Shahbaz, S
   Morsi, A
AF Rozen, Warren Matthew
   Shahbaz, Shekhib
   Morsi, Adel
TI An improved alternative to vacuum-assisted closure (VAC) as a negative
   pressure dressing in lower limb split skin grafting: A clinical trial
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE split; skin; graft; negative; pressure; dressings
ID BOLSTER
AB Background: The use of negative pressure in the dressing of split skin grafts has been shown to promote heating by a variety of mechanisms, including a decrease in interstitial oedema, an increase in perfusion and a decrease in bacterial. colonisation. Vacuum-assisted closure (VAC) dressings have, until now, been used as the archetype for negative pressure dressings and have been reflected as such in the literature. However, patient mobility and cost are still an issue with these dressings, and alternatives have been keenly sought. We describe an alternative method of negative pressure dressing, which we have found to be a safe and successful alternative in the setting of tower limb split skin grafts.
   Materials and methods: A prospective cohort investigation was performed on nine consecutive patients at Monash Medical Centre undergoing split-skin grafting for a Lower limb soft tissue defect. The dressing comprised a single cut foam sheet, a conventional disposable closed-system suction drain and an adhesive dressing.
   Results: In all nine patients, there was a 100% take of the graft, with no partial or complete loss. There were no complications encountered. Cost analysis demonstrated a minimum treatment cost of $577 over 5 days compared to $3180 for commercial VAC dressed wounds: a net saving of $2603 per patient.
   Conclusions: The use of a simple suction drain is a cheap and safe alternative to commercial VAC dressings for the treatment of Lower limb split skin grafts. Length of hospital stay and cost are superior to VAC, with no diminished clinical outcome. (c) 2007 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. ALL rights reserved.
C1 [Rozen, Warren Matthew; Shahbaz, Shekhib; Morsi, Adel] Royal Melbourne Hosp, Dept Surg, Parkville, Vic, Australia.
C3 Melbourne Health; Royal Melbourne Hospital
RP Rozen, WM (通讯作者)，Royal Melbourne Hosp, Dept Surg, 32A Wanda Rd, N Caulfield, Vic 3161, Australia.
EM warrenrozen@hotmail.com
RI Rozen, Warren Matthew/AAE-6296-2022
OI Rozen, Warren Matthew/0000-0002-4092-182X; Morsi,
   Adel/0000-0002-4298-0989
CR Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Collier M, 1997, Nurs Times, V93, P32
   Deva AK, 2000, MED J AUSTRALIA, V173, P128, DOI 10.5694/j.1326-5377.2000.tb125564.x
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Plikaitis CM, 2006, EXPERT REV MED DEVIC, V3, P175, DOI 10.1586/17434440.3.2.175
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   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
NR 9
TC 25
Z9 32
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PY 2008
VL 61
IS 3
BP 334
EP 337
DI 10.1016/j.bjps.2007.01.064
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 278FI
UT WOS:000254269600019
PM 18267313
DA 2026-07-24
ER
PT J
AU Olejnik, J
   Sedlak, I
   Brychta, I
   Tibensky, I
AF Olejnik, J.
   Sedlak, I
   Brychta, I
   Tibensky, I
TI Vacuum supported laparostomy - an effective treatment of intraabdominal
   infection
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE vacuum supported laparostomy; vacuum assisted closure; vacuum sealing;
   staged lavage; peritonitis; severe sepsis
ID MANAGEMENT; THERAPY; CLOSURE; ABDOMEN
AB Background: Notable experience using the vacuum assisted closure for abdominal wall defects was an assumption for its intra-abdominal application in severely septic patients with intra-abdominal infection. The goal of this study was to evaluate our experience with this new therapeutic technique.
   Methods: This study is a retrospective analysis and comparison of two groups of patients with severe sepsis and proven intra-abdominal source of infection. Group A consisted of 41 patients, 31 men and 10 women with the age ranging 18-78 years old (mean 49.5), who were treated surgically between 1998 and 2002 using a combination of laparostomy, multiple irrigations and abdominal drainage. Group B consisted of 46 patients, 32 men and 14 women age 18-87 years old (mean 50.8), who were treated between 2002 and 2006 using former techniques with the addition of an intra-abdominal vacuum assisted negative pressure therapy system.
   Results: In the group A the number of re-laparotomies with debridement of the open abdominal wound in general anesthesia ranged from 5 to 18 over 10 to 35 days (mean 19.4) of hospital stay. In the group B, the number of re-laparotomies decreased to 3-9 and the hospital stay decreased to 7-29 days (mean 14.5). Fifteen patients (36.6%) in the group A died because of severe sepsis, compared to 11 patients (23.9%) in the group B.
   Conclusion: Authors confirmed a significant reduction of morbidity and mortality using the intra-abdominal vacuum assisted system in the treatment of localized intra-abdominal sepsis (Tab. 2, Ref. 18).
C1 [Olejnik, J.; Sedlak, I; Brychta, I; Tibensky, I] Sloval Med Univ, Dept Gen Surg, Derers Univ Hosp, SK-83305 Bratislava, Slovakia.
C3 Slovak Medical University Bratislava
RP Olejnik, J (通讯作者)，Sloval Med Univ, Dept Gen Surg, Derers Univ Hosp, Limbova 5, SK-83305 Bratislava, Slovakia.
EM juraj.olejnik@szu.sk
RI Brychta, Ivan/JLT-0662-2023
OI Brychta, Ivan/0009-0000-9329-093X
CR Adam U, 1997, LANGENBECKS ARCH CHI, V382, P18
   Barie P S, 2001, Curr Opin Crit Care, V7, P263, DOI 10.1097/00075198-200108000-00009
   BROCK WB, 1995, AM SURGEON, V61, P30
   Bui TD, 2006, AM J SURG, V192, P235, DOI 10.1016/j.amjsurg.2006.01.013
   Fabian TC, 2007, SURG CLIN N AM, V87, P73, DOI 10.1016/j.suc.2006.09.011
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NR 18
TC 19
Z9 20
U1 0
U2 2
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2007
VL 108
IS 7
BP 320
EP 323
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 278FJ
UT WOS:000254269700010
PM 17972552
DA 2026-07-24
ER
PT J
AU Chen, Y
   Almeida, AA
   Mitnovetski, S
   Goldstein, J
   Lowe, C
   Smith, JA
AF Chen, Yi
   Almeida, Aubrey A.
   Mitnovetski, Sergei
   Goldstein, Jacob
   Lowe, Cassie
   Smith, Julian A.
TI Managing deep sternal wound infections with vacuum-assisted closure
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE cardiac surgery; deep sternal wound infection; negative pressure
   dressing; vacuum-assisted closure
ID LONG-TERM SURVIVAL; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   RISK-FACTORS; MANAGEMENT; THERAPY; DRAINAGE; RUPTURE; IMPACT; FLAPS
AB Deep sternal wound infection is an uncommon but serious complication of cardiac surgery. Currently, there is no consensus on the optimal management. Vacuum-assisted closure (VAC) has been increasingly used to facilitate wound healing. We aim to review the management of deep sternal wound infections using VAC dressing at our hospital. A retrospective review of consecutive cases of deep sternal wound infections was carried out. Median sternotomies were carried out in 2665 patients between July 2001 and June 2006. Thirty-one patients developed deep sternal wound infections (1.2%). In 26 of these patients, VAC dressing was used either as a stand-alone therapy or as an adjunct to late sternal reconstruction. Deep sternal wound infections were diagnosed on average 13 days from initial surgery. Of the patients treated with VAC dressing, 17 (65%) had stand-alone VAC therapy and 9 had VAC therapy followed by sternal reconstruction. The average duration of VAC dressing in the two groups were 21 and 13 days respectively. There were seven in-hospital deaths, six in the stand-alone VAC group and one death from a reconstructive patient who did not have VAC therapy. The length of hospital stay was similar in two VAC groups (37 vs 45 days). Median follow up was 17 months. No late relapse was found in the stand-alone group. In the intermediate therapy group, two patients had chronic wound sinuses and one patient had a wound collection. Vacuum-assisted closure dressing may be used both as a stand-alone and as an intermediate therapy for deep sternal wound infection. Reconstructive surgery may be avoided in a significant proportion of patients. No late relapse has been associated with VAC use.
C1 [Chen, Yi; Almeida, Aubrey A.; Mitnovetski, Sergei; Goldstein, Jacob; Lowe, Cassie; Smith, Julian A.] Monash Univ, Cardiothorac Surg Unit, Monash Med Ctr, Melbourne, Vic 3004, Australia.
   [Almeida, Aubrey A.; Goldstein, Jacob; Smith, Julian A.] Monash Univ, Dept Surg, Melbourne, Vic 3004, Australia.
C3 Monash University; Monash University
RP Chen, Y (通讯作者)，Monash Med Ctr, Cardiothorac Surg Unit, 246 Clayton Rd, Clayton, Vic 3168, Australia.
EM chen_yi11@hotmail.com
OI Smith, Julian/0000-0003-1244-4277
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NR 20
TC 19
Z9 21
U1 0
U2 0
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1445-1433
J9 ANZ J SURG
JI ANZ J. Surg.
PD MAY
PY 2008
VL 78
IS 5
BP 333
EP 336
DI 10.1111/j.1445-2197.2008.04467.x
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 282HO
UT WOS:000254558700007
PM 18380722
DA 2026-07-24
ER
PT J
AU Baser, NT
   Isik, V
   Bulutoglu, R
   Gökrem, S
   Aslan, G
AF Baser, Nesrin Tan
   Isik, Volkan
   Bulutoglu, Refika
   Goekrem, Serdar
   Aslan, Guercan
TI Subatmospheric pressure wound dressing in wound management:: Medical
   education
SO TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
LA Turkish
DT Article
DE wound healing; occlusive dressings; varicose ulcer; diabetic foot;
   surgical wound dehiscence
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; TOPICAL
   NEGATIVE-PRESSURE; DIABETIC FOOT WOUNDS; SECURING SKIN-GRAFTS; DEGLOVING
   INJURIES; DONOR-SITE; TISSUE DEFECTS; ABDOMINAL-WALL; STERNAL WOUNDS
AB Subatmospheric pressure dressing (SPWD) is a new wound dressing that has been used latterly. SPWD is the controlled application of subatmospheric pressure to a wound using an electrical pump to intermittently or continuously convey subatmospheric pressure through connecting tubing to a specialized wound dressing. Recent studies with this wound dressing, the use of which was initially recomended for chronic wounds, has shown that it can effectively be used for acute wounds, skin grafted areas and donor site care, degloving injuries and bums. SPWD is a topical treatment used to promote healing in acute and chronic wounds by applying subatmospheric pressure to the wound bed. Four board mechanisms of action are proposed: increase of local blood supply, mechanical deformation, removal of harmful enzymes from the wound bed, decrease intertisiel edema. The combination of these mechanisms makes the SPWD treatment an extremely versatile tool in the armamentarium of wound healing. SPWD is generally well tolerated and, with few complications. Numerous case studies and articles have documented this treatment effectiveness. But, recent experimental studies, evaluations and personal experience raise many questions about the currently treatment protocol of SPWD: Is intermittent subatmospheric pressure therapy equivalent to continuos subatmospheric pressure wound therapy, how is optimal pressure level for wound healing?
   In this article, the past and present of subatmospheric pressure wound care is revised by considering articles within the accessible literature. Furthermore, insufficient and inquisitional aspects of this method is also emphasized.
C1 [Baser, Nesrin Tan; Isik, Volkan; Bulutoglu, Refika; Goekrem, Serdar; Aslan, Guercan] Ankara Egitim Arastirma Hastanesi, Rekonstruktif Estetek Cerrahi Klin, Ankara, Turkey.
C3 Ankara Training & Research Hospital
RP Baser, NT (通讯作者)，Ankara Egitim Arastirma Hastanesi, Rekonstruktif Estetek Cerrahi Klin, 2 Plast, Ankara, Turkey.
EM drbaser@superonline.com
RI Tan Başer, Nesrin/AAR-8330-2021
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NR 94
TC 3
Z9 3
U1 0
U2 7
PU ORTADOGU AD PRES & PUBL CO
PI ANKARA
PA TURKOCAGI CAD NO 30, BALGAT, ANKARA, 06520, TURKEY
SN 1300-0292
EI 2146-9040
J9 TURK KLIN TIP BILIM
JI Turk. Klin. Tip Bilim. Derg.
PD DEC
PY 2007
VL 27
IS 6
BP 902
EP 915
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 282QT
UT WOS:000254583000014
DA 2026-07-24
ER
PT J
AU Blume, PA
   Walters, J
   Payne, W
   Ayala, J
   Lantis, J
AF Blume, Peter A.
   Walters, Jodi
   Payne, Wyatt
   Ayala, Jose
   Lantis, John
TI Comparison of negative pressure wound therapy using vacuum-assisted
   closure with advanced moist wound therapy in the treatment of diabetic
   foot ulcers: A multicenter randomized controlled trial
SO DIABETES CARE
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Podiatric-Medicine
CY AUG 16-19, 2007
CL Philadelphia, PA
SP Amer Podiatr Med
AB OBJECTIVE - The purpose of this study was to evaluate safety and clinical efficacy of negative pressure wound therapy (NPWT) compared with advanced moist wound therapy (AMWT) to treat foot ulcers in diabetic patients.
   RESEARCH DESIGN AND METHODS- This multicenter randomized controlled trial enrolled 342 patients with a mean age of 58 years; 79% were male, Complete ulcer closure was defined as skin closure (100% reepithelization) without drainage or dressing requirements. Patients were randomly assigned to either NPWT (vacuum-assisted closure) or AMWT (predominately hydrogels and alginates) and received standard off-loading therapy as needed. The trial evaluated treatment until day 112 or ulcer closure by any means. Patients whose wounds achieved ulcer closure were followed at 3 and 9 months. Each study visit included closure assessment by wound examination and tracings.
   RESULTS - A greater proportion of foot ulcers achieved complete ulcer closure with NPWT (73 of 169, 43.2%) than with AMWT (48 of 166, 28.9%) within the 112-day active treatment phase (P = 0.007). The Kaplan-Meier median estimate for 100% ulcer closure was 96 days (95% CI 75.0-114.0) for NPWT and not determinable for AMWT (P = 0.001). NPWT patients experienced significantly (P = 0.035) fewer secondary amputations. The proportion of home care therapy days to total therapy days for NPWT was 9,471 of 10,579 (89.5%) and 12,210 of 12,810 (95.3%) for AMWT. In assessing safety, no significant difference between the groups was observed in treatment-related complications such as infection, cellulitis, and osteomyelitis at 6 months.
   CONCLUSIONS - NPWT appears to be as safe as and more efficacious than AMWT for the treatment of diabetic foot ulcers.
C1 [Blume, Peter A.] N Amer Ctr Limb Preservat, New Haven, CT 06515 USA.
   [Walters, Jodi] So Arizona Vet Affairs Med Ctr, Tucson, AZ USA.
   [Payne, Wyatt] Bay Pines VA Healthcare Syst, Inst Tissue Regenerat Repair & Rehabil, Bay Pines, FL USA.
   Univ S Florida, Div Plast Surg, Tampa, FL USA.
   [Ayala, Jose] Valley Baptist Hosp, Brownsville, TX USA.
   [Lantis, John] St Lukes Roosevelt Hosp, New York, NY 10025 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Southern Arizona Veterans Affairs Health Care System; State University
   System of Florida; University of South Florida; Mount Sinai Morningside;
   Mount Sinai West
RP Blume, PA (通讯作者)，N Amer Ctr Limb Preservat, 506 Blake St, New Haven, CT 06515 USA.
EM peter.b@snet.net
CR [Anonymous], GUID MAN WOUNDS PAT
   [Anonymous], 2005, NAT DIAB FACT SHEET
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   Marston WA, 2003, DIABETES CARE, V26, P1701, DOI 10.2337/diacare.26.6.1701
   Mulder G, 2003, WOUNDS, V15, P92
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   Singh N, 2005, JAMA-J AM MED ASSOC, V293, P217, DOI 10.1001/jama.293.2.217
   *US DEP HHS, 2000, GUID IND CHRON CUT U, P15
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   2004, VAC THERAPY CLIN GUI
NR 20
TC 451
Z9 542
U1 3
U2 70
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD APR
PY 2008
VL 31
IS 4
BP 631
EP 636
DI 10.2337/dc07-2196
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 282UE
UT WOS:000254591900001
PM 18162494
OA Bronze
DA 2026-07-24
ER
PT J
AU Wedemeyer, J
   Schneider, A
   Manns, MP
   Jackobs, S
AF Wedemeyer, Jochen
   Schneider, Andrea
   Manns, Michael P.
   Jackobs, Steffan
TI Endoscopic vacuum-assisted closure of upper intestinal anastomotic leaks
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Article
ID ESOPHAGEAL; MANAGEMENT; SURGERY; STENTS; CARCINOMA
AB Background: Management of intrathoracic anastomotic leaks remains an interdisciplinary challenge. Established treatment options include percutaneous drainage, endoscopic closure, or even surgical revision. All these procedures are associated with high morbidity and mortality rates.
   Objective: We report a new, effective endoscopic treatment option for intrathoracic esophageal anastomotic leaks by using an endoscopic vacuum-assisted Closure system.
   Patients: Two patients with intrathoracic anastomotic leaks after esophagectomy and gastrectomy were included.
   Methods: Surgical reinterventions failed to seal the leaks in 1 patient, whereas in the other patient the anastomotic leakage persisted after endoscopic placement of 2 covered self-expanding metal stents. We endoscopically placed transnasal draining tubes that were armed with a size-adjusted sponge at their distal tip in the necrotic anastomotic cavities. Continuous suction was applied. Sponge and drain were changed twice a week.
   Results: No complications were noted during the course of treatment. After a median of 15 days, closure of the wound cavities was achieved in all cases. A median of 5 endoscopic interventions was necessary. Both patients returned gradually to a solid diet without recurrence of the leaks.
   Conclusion: Endoscopic vacuum-assisted closure might be an effective alternative in the treatment of upper intestinal anastomotic leaks.
C1 [Wedemeyer, Jochen; Schneider, Andrea; Manns, Michael P.] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany.
   [Jackobs, Steffan] Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, D-30625 Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School
RP Wedemeyer, J (通讯作者)，Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
RI Manns, Michael/AFG-3063-2022
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NR 17
TC 149
Z9 176
U1 0
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
EI 1097-6779
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD APR
PY 2008
VL 67
IS 4
BP 708
EP 711
DI 10.1016/j.gie.2007.10.064
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 282VW
UT WOS:000254596300022
PM 18374029
DA 2026-07-24
ER
PT J
AU Peinemann, F
   McGauran, N
   Sauerland, S
   Lange, S
AF Peinemann, Frank
   McGauran, Natalie
   Sauerland, Stefan
   Lange, Stefan
TI Negative pressure wound therapy: Potential publication bias caused by
   lack of access to unpublished study results data
SO BMC MEDICAL RESEARCH METHODOLOGY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SYSTEMATIC REVIEWS; PHARMACEUTICAL-INDUSTRY;
   RANDOMIZED-TRIAL; LEG ULCERS; METAANALYSES; SPONSORSHIP; MANAGEMENT;
   EFFICACY; IMPACT
AB Background: Negative pressure wound therapy (NPWT) is widely applied, although the evidence base is weak. Previous reviews on medical interventions have shown that conclusions based on published data alone may no longer hold after consideration of unpublished data. The main objective of this study was to identify unpublished randomised controlled trials (RCTs) on NPWT within the framework of a systematic review.
   Methods: RCTs comparing NPWT with conventional wound therapy were identified using MEDLINE, EMBASE, CINAHL and The Cochrane Library. Every database was searched from inception to May 2005. The search was updated in December 2006. Reference lists of original articles and systematic reviews, as well as congress proceedings and online trial registers, were screened for clues to unpublished RCTs. Manufacturers of NPWT devices and authors of conference abstracts were contacted and asked to provide study information. Trials were considered nonrandomised if concealment of allocation to treatment groups was classified as "inadequate". The study status was classified as "completed", "discontinued", "ongoing" or "unclear". The publication status of completed or discontinued RCTs was classified as "published" if a full-text paper on final study results ( completed trials) or interim results (discontinued trials) was available, and "unpublished" if this was not the case. The type of sponsorship was also noted for all trials.
   Results: A total of 28 RCTs referring to at least 2755 planned or analysed patients met the inclusion criteria: 13 RCTs had been completed, 6 had been discontinued, 6 were ongoing, and the status of 3 RCTs was unclear. Full-text papers were available on 30% of patients in the 19 completed or discontinued RCTs ( 495 analysed patients in 10 published RCTs vs. 1154 planned patients in 9 unpublished RCTs). Most information about conference abstracts and unpublished study information referring to trials that were unpublished at the time these documents were generated was obtained from the manufacturer Kinetic Concepts Inc. ( KCI) ( 19 RCTs), followed by The Cochrane Library ( 18) and a systematic review ( 15). We were able to obtain some information on the methods of unpublished RCTs, but results data were either not available or requests for results data were not answered; the results of unpublished RCTs could therefore not be considered in the review. One manufacturer, KCI, sponsored the majority of RCTs (19/28; 68%). The sponsorship of the remaining trials was unclear.
   Conclusion: Multi-source comprehensive searches identify unpublished RCTs. However, lack of access to unpublished study results data raises doubts about the completeness of the evidence base on NPWT.
C1 [Peinemann, Frank; McGauran, Natalie; Lange, Stefan] Inst Qual & Efficiency Hlth Care IQWiG, D-51105 Cologne, Germany.
   [Sauerland, Stefan] Univ Witten Herdecke, Inst Res Operat Med, D-51109 Cologne, Germany.
C3 Witten Herdecke University
RP Peinemann, F (通讯作者)，Inst Qual & Efficiency Hlth Care IQWiG, Dillenburger Str 27, D-51105 Cologne, Germany.
EM frank.peinemann@iqwig.de; n.mcgauran@iqwig.de;
   stefan.sauerland@infomuni-wh.de; stefan.lange@iqwig.de
RI ; Peinemann, Frank/H-2800-2019
OI Sauerland, Stefan/0000-0003-1048-796X; Peinemann,
   Frank/0000-0002-4727-1313
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   [Anonymous], Assessing risk of bias in a non-randomized study
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NR 82
TC 35
Z9 39
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2288
J9 BMC MED RES METHODOL
JI BMC Med. Res. Methodol.
PD FEB 11
PY 2008
VL 8
AR 4
DI 10.1186/1471-2288-8-4
PG 16
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 288GJ
UT WOS:000254973900001
PM 18267008
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Andrews, BT
   Smith, RB
   Hoffman, HT
   Funk, GF
AF Andrews, Brian T.
   Smith, Russell B.
   Hoffman, Henry T.
   Funk, Gerry F.
TI Orocutaneous and pharyngocutaneous fistula closure using a
   vacuum-assisted closure system
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fistula closure; salivary leak; topical negative pressure dressing;
   vacuum-assisted closure
ID ENTEROCUTANEOUS FISTULAS; RADIATION-THERAPY; WOUND CONTROL; MANAGEMENT;
   COMPLICATIONS; LARYNGECTOMY; SURGERY; HEAD
AB Objectives: The vacuum-assisted closure (VAC) system is a topical negative pressure dressing that has been used extensively to manage a multitude of complicated wounds, including enterocutaneous fistula. We hypothesize that the VAC system may also facilitate the closure of orocutaneous and pharyngocutaneous fistulas.
   Methods: A retrospective chart review was performed.
   Results: Three patients were identified. Two patients developed fistulas after undergoing salvage laryngectomy, and 1 patient developed a fistula after having a hemiglossectomy defect reconstructed by a radial forearm free flap. The VAC system was successful in closing the fistula in 2 of the 3 patients. Complete fistula closure took 3 and 11 days in the 2 cases. The 1 failure of fistula closure was due to poor collapsibility of the neck tissue along the fistula tract caused by fibrosis following prior radiotherapy.
   Conclusions: The VAC system is a feasible treatment option for closing head and neck fistulas, especially when collapsible tissue is present at the fistula site.
C1 [Andrews, Brian T.; Smith, Russell B.; Hoffman, Henry T.; Funk, Gerry F.] Univ Iowa, Coll Med, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
C3 University of Iowa
RP Funk, GF (通讯作者)，Univ Iowa, Coll Med, Dept Otolaryngol Head & Neck Surg, 21200 Pomerantz Pavil,200 Hawkins Dr, Iowa City, IA 52242 USA.
OI Hoffman, Henry/0000-0003-4486-855X; Andrews, Brian/0000-0003-3994-6808
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NR 15
TC 34
Z9 42
U1 0
U2 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 298
EP 302
DI 10.1177/000348940811700410
PG 5
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500010
PM 18478840
DA 2026-07-24
ER
PT J
AU Baharestani, MM
AF Baharestani, Mona Mylene
TI Negative pressure wound therapy in the adjunctive management of
   necrotizing fascitis: Examining clinical outcomes
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE necrotizing fascitis; case study; negative pressure wound therapy;
   treatment duration; length of hospital stay
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INFECTIONS; FASCIITIS; DEVICE; SKIN
AB Prompt diagnosis and treatment of necrotizing fascitis reduces the morbidity and mortality rates of this devastating disease. To examine the clinical outcomes of using negative pressure wound therapy in the adjunctive management of wounds secondary to necrotizing fascitis, a retrospective review of medical records was conducted. Participants included 11 consecutive patients (16 wounds) with a diagnosis of necrotizing fascitis admitted to a teaching hospital between 2000 and 2005 and treated on an inpatient basis with negative pressure wound therapy. The patients included seven men, four women (average age 54 years; range 18 to 82 years). Variables abstracted from the medical records and consultation notes included: demographic information, tissue and blood bacteriological data, wound history, wound healing outcomes, duration of negative pressure wound therapy, length of hospital stay, and mortality and morbidity information. Variables were entered into an electronic database and analyzed. Operative tissue biopsies were obtained and all participants received serial surgical debridements as well as infection, nutrition, and hemodynamic support. Negative pressure wound therapy was applied to the wound(s) at 125 mm Hg continuous negative pressure until reconstructive closure could be performed. Most wounds (10) were on lower extremities, seven patients presented with sepsis, and beta-hemolytic Streptococcus was identified in nine wounds. Mean number of negative pressure wound therapy treatment days was 25 (range: 7 to 74), mean length of stay was 67 days (range: 21 to 186). All wounds were successfully closed - 73% received split-thickness skin grafts, 27% required flaps, 100% limb salvage was achieved, and all patients survived. No negative pressure wound therapy or dressing-associated complications were observed. Negative pressure wound therapy was found to be a viable adjunctive treatment in the management of wounds associated with necrotizing fascitis.
C1 [Baharestani, Mona Mylene] James H Quillen Vet Affairs Med Ctr, Johnson City, TN USA.
   E Tennessee State Univ, Ctr Nursing Res, Off 112, Johnson City, TN 37614 USA.
C3 East Tennessee State University
RP Baharestani, MM (通讯作者)，E Tennessee State Univ, Ctr Nursing Res, Off 112, Johnson City, TN 37614 USA.
EM baharest@etsu.edu
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   [No title captured]
NR 38
TC 17
Z9 20
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD APR
PY 2008
VL 54
IS 4
BP 44
EP 50
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 290TJ
UT WOS:000255144800006
PM 18480505
DA 2026-07-24
ER
PT J
AU Sachithanandan, A
   Nanjaiah, P
   Nightingale, P
   Wilson, IC
   Graham, TR
   Rooney, SJ
   Keogh, BE
   Pagano, D
AF Sachithanandan, Anand
   Nanjaiah, Prakash
   Nightingale, Peter
   Wilson, Ian C.
   Graham, Timothy R.
   Rooney, Stephen J.
   Keogh, Bruce E.
   Pagano, Domenico
TI Deep sternal wound infection requiring revision surgery: impact on
   mid-term survival following cardiac surgery
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 21st Annual Meeting of the
   European-Association-for-Cardio-Thoracic-Surgery (EACTS)
CY SEP 16-19, 2007
CL Geneva, SWITZERLAND
SP European Assoc Cardio Thorac Surg (EACTS)
DE deep sternal infection; survival
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; BYPASS GRAFT-SURGERY;
   RISK-FACTORS; COMPLICATIONS; MEDIASTINITIS
AB Objective: To assess the impact of deep sternal wound infection on in-hospital mortality and mid-term survival following adult cardiac surgery. Methods: Prospectively collected data on 4586 consecutive patients who underwent a cardiac surgical procedure via a median sternotomy from 1st January 2001 to 31st December 2005 were analysed. Patients with a deep sternal wound infection (DSWI) were identified in accordance with the Centres for Disease Control and Prevention guidelines. Nineteen variables (patient-related, operative and postoperative) were analysed. Logistic regression analysis was used to calculate a propensity score for each patient. Late survival data were obtained from the UK Central Cardiac Audit Database. Mean follow-up of DSWI patients was 2.28 years. Results: DSWI requiring revision surgery developed in 1.65% (76/4586) patients. Stepwise multivariable logistic regression analysis identified age, diabetes, a smoking history and ventilation time as independent predictors of a DSWI. DSWI patients were more likely to develop renal failure, require reventitation and a tracheostomy postoperatively. Treatment included vacuum assisted closure therapy in 81.5% (62/76) patients and sternectomy with musculocutaneous flap reconstruction in 35.5% (27/76) patients. In-hospital mortality was 9.2% (7/76) in DSWI patients and 3.7% (167/4510) in non-DSWI patients (OR 1.300 (0.434-3.894) p = 0.639). Survival with Cox regression analysis with mean propensity score (co-variate) showed freedom from all-cause mortality in DSWI at 1, 2, 3 and 4 years was 91%, 89%, 84% and 79%, respectively compared with 95%, 93%, 90% and 86%, respectively for patients without DSWI ((p = 0.082) HR 1.59 95% CI (0.94-2.68)). Conclusion: DSWI is not an independent predictor of a higher in-hospital mortality or reduced mid-term survival following cardiac surgery in this population. (C) 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
C1 [Sachithanandan, Anand; Nanjaiah, Prakash; Wilson, Ian C.; Graham, Timothy R.; Rooney, Stephen J.; Pagano, Domenico] Univ Birmingham, NHS Fdn Trust, Dept Cardiothorac Surg, Birmingham B15 2TH, W Midlands, England.
   [Nightingale, Peter] Univ Hosp Birmingham, NHS Fdn Trust, Wellcome Trust Clin Res Facil, Birmingham, W Midlands, England.
   [Keogh, Bruce E.] UCL, Natl Inst Clin Outcomes Res, London WC1E 6BT, England.
C3 Oxford University Hospitals NHS Foundation Trust; University of
   Birmingham; Oxford University Hospitals NHS Foundation Trust; University
   of Birmingham; University of London; University College London
RP Pagano, D (通讯作者)，Univ Birmingham, NHS Fdn Trust, Dept Cardiothorac Surg, Birmingham B15 2TH, W Midlands, England.
EM domenico.pagano@uhb.nhs.uk
CR Borger MA, 1998, ANN THORAC SURG, V65, P1050, DOI 10.1016/S0003-4975(98)00063-0
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NR 21
TC 39
Z9 43
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD APR
PY 2008
VL 33
IS 4
BP 673
EP 677
DI 10.1016/j.ejcts.2008.01.002
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 292KU
UT WOS:000255265700041
PM 18243720
OA Bronze
DA 2026-07-24
ER
PT J
AU Rinker, B
   Amspacher, JC
   Wilson, PC
   Vasconez, HC
AF Rinker, Brian
   Amspacher, Jonathan C.
   Wilson, Patrick C.
   Vasconez, Henry C.
TI Subatmospheric pressure dressing as a bridge to free tissue transfer in
   the treatment of open tibia fractures
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 50th Annual Meeting of the
   Southeastern-Society-of-Plastic-and-Reconstructive-Surgeons
CY JUN 09-13, 2007
CL Destin, FL
SP SE Soc Plastic & Reconstruct Surg
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; WOUND THERAPY;
   LOWER-EXTREMITY; MICROSURGICAL RECONSTRUCTION; TEMPORARY TREATMENT;
   MANAGEMENT; TRAUMA; STATE
AB Background: Free flap reconstruction performed shortly after injury is associated with reduced complications but is not always feasible. Subatmospheric pressure dressings have several beneficial effects on wounds. This study reviewed a large series of open tibia fractures to determine whether subatmospheric pressure dressings affected complication rates.
   Methods: One hundred five patients underwent free muscle flap reconstruction for open tibia fractures between 1991 and 2005. Patients were divided into three groups: acute (flap performed 1 to 7 days after injury), subacute (8 to 42 days after injury), and chronic (>42 days after injury). Five outcome measures were used: infectious complications, flap-related complications, surgical procedures, hospital stay, and time to bony union. The subacute group was divided into patients who underwent subatmospheric pressure dressing therapy and those who did not.
   Results: The complication rate in the subacute group (n = 55) was 47 percent, compared with 39 percent in the chronic group (n = 18) and 31 percent in the acute group (n = 32). Time to union was significantly shorter in the acute group than in the other groups. Subacute patients who underwent subatmospheric dressing therapy had lower overall complication (35 percent), infectious complication (6 percent), and flap-related complication rates (12 percent) than those who did not (53, 18, and 21 percent, respectively). Time to union was significantly shorter with the dressings.
   Conclusion: Subatmospheric pressure dressing therapy as a "bridge" to free flap reconstruction in patients with open tibia fractures was associated with reduced complication rates in the subacute group, suggesting that the dressings may effectively extend the acute period when early free tissue transfer is not possible.
C1 [Rinker, Brian; Amspacher, Jonathan C.; Wilson, Patrick C.; Vasconez, Henry C.] Univ Kentucky, Div Plast Surg, Kentucky Clin, Lexington, KY 40536 USA.
C3 University of Kentucky
RP Rinker, B (通讯作者)，Univ Kentucky, Div Plast Surg, Kentucky Clin, K454, Lexington, KY 40536 USA.
EM brink2@uky.edu
RI Wilson, Patrick/HGC-3157-2022
CR Archdeacon MT, 2006, J ORTHOP TRAUMA, V20, P134, DOI 10.1097/01.bot.0000184147.82824.7c
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NR 37
TC 51
Z9 57
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAY
PY 2008
VL 121
IS 5
BP 1664
EP 1673
DI 10.1097/PRS.0b013e31816a8d9d
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 294VU
UT WOS:000255435200019
PM 18453991
DA 2026-07-24
ER
PT J
AU Petzina, R
   Ugander, M
   Gustafsson, L
   Engblom, H
   Hetzer, R
   Arheden, H
   Ingemansson, R
   Malmsjö, M
AF Petzina, Rainer
   Ugander, Martin
   Gustafsson, Lotta
   Engblom, Henrik
   Hetzer, Roland
   Arheden, Hakan
   Ingemansson, Richard
   Malmsjo, Malin
TI Topical negative pressure therapy of a sternotomy wound increases
   sternal fluid content but does not affect internal thoracic artery blood
   flow:: Assessment using magnetic resonance imaging
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS;
   CONVENTIONAL TREATMENT; GREATER OMENTUM; COMPLICATIONS; INFECTION;
   TRANSPOSITION; SURGERY; WALL
AB Objective: Topical negative pressure therapy has excellent healing effects in poststernotomy mediastinitis. Topical negative pressure therapy reduces bacterial counts, increases wound edge microvascular blood flow and granulation tissue formation, and facilitates healing. No study has yet been performed to examine the effect of topical negative pressure on the blood and fluid content in the sternal bone marrow, which is a crucial component in osteitis.
   Methods: Eight pigs underwent median sternotomy, left internal thoracic artery harvesting, followed by topical negative pressure treatment. Magnetic resonance imaging was used to quantify both tissue fluid and/or blood content (T2-weighted short tau inversion recovery [T2-STIR]) and internal thoracic artery blood flow (flow quantification).
   Results: Before application of topical negative pressure, the T2-STIR signal intensity ratio was lower for the left than for the right hemisternum (left, 1.3; right, 2.6), indicating lower levels of tissue fluid content on the left, devascularized side. On application of topical negative pressure, the T2-STIR signal intensity ratio increased immediately for both the sternal bone and the pectoral muscle (left hemisternum after 4 minutes of topical negative pressure: 2.3), leveled off after 4 minutes, and remained unchanged for the ensuing 40 minutes, suggesting movement of fluid and/or blood into the tissue of the wound edge. Topical negative pressure did not affect blood flow in the right internal thoracic artery.
   Conclusions: T2-STIR measurements show that topical negative pressure increases sternotomy wound edge tissue fluid and/or blood content. Topical negative pressure creates a pressure gradient that presumably draws fluid from the surrounding tissue to the sternal wound edge and into the vacuum source. This "endogenous drainage'' may be one possible mechanism by which osteitis is resolved by topical negative pressure in poststernotomy mediastinitis.
C1 Lund Univ, SE-22184 Lund, Sweden.
   [Petzina, Rainer; Gustafsson, Lotta; Malmsjo, Malin] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
   [Engblom, Henrik; Arheden, Hakan] Univ Lund Hosp, Dept Clin Physiol, S-22185 Lund, Sweden.
   [Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Petzina, Rainer; Hetzer, Roland] Deutsch Herzzentrum Berlin, Berlin, Germany.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Skane University Hospital; Lund University; Skane University
   Hospital; German Heart Center Berlin
RP Malmsjö, M (通讯作者)，Lund Univ, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Ugander, Martin/AAQ-4447-2021
OI Ugander, Martin/0000-0003-3665-2038; Ingemansson,
   Richard/0000-0001-7623-8953; Gustafsson, Lotta/0000-0002-9826-9133;
   Petzina, Rainer/0000-0002-0688-5482; Maljö, Malin/0000-0001-9849-9599
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NR 28
TC 8
Z9 8
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD MAY
PY 2008
VL 135
IS 5
BP 1007
EP 1013
DI 10.1016/j.jtcvs.2007.09.070
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 295ZH
UT WOS:000255512800007
PM 18455577
OA Bronze
DA 2026-07-24
ER
PT J
AU Ichioka, S
   Watanabe, H
   Sekiya, N
   Shibata, M
   Nakatsuka, T
AF Ichioka, Shigeru
   Watanabe, Hiromi
   Sekiya, Naomi
   Shibata, Masahiro
   Nakatsuka, Takashi
TI A technique to visualize wound bed microcirculation and the acute effect
   of negative pressure
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CUTANEOUS BLOOD-FLOW; PERFUSION; FOUNDATION;
   STATE; MODEL
AB Although previous studies have proved that subatmospheric pressure in vacuum assisted closure therapy increased blood flow at the wound edge, no reports have presented data on blood flow in the wound bed. This study examined a technique that visualized microcirculation of the wound bed and estimated the acute effect of negative pressure. The superficial stratum of the mouse gluteal skin was microsurgically excised preserving the subdermal vascular plexus. The preserved vessels were visualized as the wound bed microcirculation using an intravital microscope-video-computer system. Three levels of negative pressure (-125 mmHg [n=12], -500 mmHg [n=12], 0 mmHg [n=8]) were applied to the wound. Our experimental model successfully and quantitatively visualized wound bed microcirculation under negative pressure application. A negative pressure of -125 mmHg significantly increased wound bed blood flow immediately after pressure application, maintained for 1 minute after pressure release, whereas in the -500 mmHg group blood flow decreased with time and reached a statistically significant level 5 minutes after pressure application. These findings reinforce the hypothesis that enhanced blood flow in the wound bed as well as at the wound edge may contribute to the beneficial effects of certain levels of negative pressure therapy for wound perfusion.
C1 [Ichioka, Shigeru; Watanabe, Hiromi; Sekiya, Naomi; Nakatsuka, Takashi] Saitama Med Univ, Dept Plast & Reconstruct Surg, Moroyama, Saitama 3500495, Japan.
   [Shibata, Masahiro] Univ Tokyo, Grad Sch Med, Dept Biomol Engn, Tokyo, Japan.
C3 Saitama Medical University; University of Tokyo
RP Ichioka, S (通讯作者)，Saitama Med Univ, Dept Plast & Reconstruct Surg, 38 Morohongo, Moroyama, Saitama 3500495, Japan.
EM ichioka-stm@umin.ac.jp
CR [Anonymous], 2005, Wound Healing and Ulcers of the Skin: Diagnosis and Therapy, DOI DOI 10.1007/3-540-26761-12
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 16
TC 72
Z9 82
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1067-1927
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2008
VL 16
IS 3
BP 460
EP 465
DI 10.1111/j.1524-475X.2008.00390.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 298DL
UT WOS:000255666500017
PM 18471264
OA Bronze
DA 2026-07-24
ER
PT J
AU Pirela-Cruz, MA
   Machen, MS
   Esquivel, D
AF Pirela-Cruz, Miguel A.
   Machen, M. Shaun
   Esquivel, David
TI Management of large soft-tissue wounds with negative pressure therapy -
   Lessons learned from the war zone
SO JOURNAL OF HAND THERAPY
LA English
DT Article; Proceedings Paper
CT Conference on the Contributions of the Military Hand Therapist in Combat
   and Postdeployment Rehabilitation
CY 2005
CL San Antonio, TX
SP Brook Army Med Ctr
ID VACUUM-ASSISTED CLOSURE; INJURIES; EXPERIENCE; TRAUMA
AB The recent conflicts in Afghanistan and Iraq have demonstrated that body armor has led to increase survival of combatants but the extremity injuries have been alarming. The increased. numbers of extremity injuries have led to the acceptance and use of negative pressure therapy (NPT) in managing large wounds. This article reviews some of the lessons learned in treating wounds of the upper extremity using NPT.
C1 [Pirela-Cruz, Miguel A.] Texas Tech Univ, Hlth Sci Ctr, Dept Orthopaed & Rehabil, El Paso, TX 79905 USA.
   [Machen, M. Shaun] William Beaumont Army Med Ctr, El Paso, TX 79920 USA.
   [Esquivel, David] RE Thomason Hosp, El Paso, TX USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center El Paso; Texas Tech University; William Beaumont Army Medical
   Center
RP Pirela-Cruz, MA (通讯作者)，Texas Tech Univ, Hlth Sci Ctr, Dept Orthopaed & Rehabil, 4800 Alberta Ave, El Paso, TX 79905 USA.
EM Miguel.Pirelacruz@luke.uf.mil
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Leininger BE, 2006, J TRAUMA, V61, P1207, DOI 10.1097/01.ta.0000241150.15342.da
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Moues C M, 2005, J Wound Care, V14, P224
   Phelps JR, 2006, OSTOMY WOUND MANAG, V52, P54
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Stawicki SP, 2008, INJURY, V39, P93, DOI 10.1016/j.injury.2007.06.011
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NR 18
TC 9
Z9 14
U1 0
U2 1
PU HANLEY & BELFUS-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0894-1130
J9 J HAND THER
JI J. Hand Ther.
PD APR-JUN
PY 2008
VL 21
IS 2
BP 196
EP 202
DI 10.1197/j.jht.2007.12.007
PG 7
WC Orthopedics; Rehabilitation; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rehabilitation; Surgery
GA 299PW
UT WOS:000255768500013
PM 18436141
DA 2026-07-24
ER
PT J
AU Bapat, V
   El-Muttardi, N
   Young, C
   Venn, G
   Roxburgh, J
AF Bapat, Vinayak
   El-Muttardi, Naguib
   Young, Christopher
   Venn, Graham
   Roxburgh, James
TI Experience with vacuum-assisted closure of sternal wound infections
   following cardiac surgery and evaluation of chronic complications
   associated with its use
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID MUSCLE FLAPS; POSTSTERNOTOMY MEDIASTINITIS; STERNOTOMY; IRRIGATION;
   THERAPY
AB Objectives: We report our experience in use of Vacuum-assisted closure therapy (VAC) in the treatment of poststernotomy wound infection with emphasis on recurrent wound-related problems after use of VAC and their treatment. Methods: Between July 2000 and June 2003, 2706 patients underwent various cardiac procedures via median sternotomy. Forty-nine patients with postoperative sternal wound infection (1.9%) were managed with VAC. Wounds were classified as either superficial sternal wound infection (28 patients) or deep sternal wound infection (21 patients). In the superficial sternal wound infection group, 23 patients had VAC as definitive treatment (GroupA), while five patients (Group B) had VAC followed by surgical closure. Similarly, in the deep sternal wound infection group, 12 patients had VAC as definitive treatment (Group C), while nine patients had VAC followed by surgical closure (Group D). Patients were discharged after satisfactory wound closure. Upon discharge patients were followed up at interval of three to six months. Recurrent sternal problems when identified were investigated and additional surgical procedures were carried out when necessary. Results: There were nine deaths, all due to unrelated causes except in one patient who died of right ventricular rupture (Group C). Nine patients in Group A had recurrent wound problems of which six had VAC system for > 21 days. Three patients underwent extensive debridement due to sternal osteomyelitis. All eight patients in Group B presented with chronic wound-related problems and underwent multiple debridements. Four patients had laparoscopic omental flaps. In contrast 14 patients (Group B and D) who were treated with shorter duration of VAC followed by either a flap or direct surgical closure, did not present with recurrent problems. Conclusion: VAC therapy is a safe and reliable option in the treatment of sternal wound infection. However, prolonged use of VAC system as a replacement for surgical closure of sternal wound appears to be associated with recurrent problems of the sternal wound. Strategy of use of VAC for a short duration followed by early surgical closure appears favorable.
C1 [Bapat, Vinayak; Young, Christopher; Venn, Graham; Roxburgh, James] St Thomas Hosp, Dept Cardiothorac Surg, London, England.
   [El-Muttardi, Naguib] St Thomas Hosp, Dept Plast Surg, London, England.
C3 Guy's & St Thomas' NHS Foundation Trust; Guy's & St Thomas' NHS
   Foundation Trust
RP Bapat, V (通讯作者)，123 Turney Rd, London, England.
EM vnbapat@yahoo.com
RI /AAA-2540-2020
CR Arbulu A, 1996, EUR J CARDIO-THORAC, V10, P110, DOI 10.1016/S1010-7940(96)80132-1
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NR 24
TC 46
Z9 50
U1 0
U2 2
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0886-0440
J9 J CARDIAC SURG
JI J. Card. Surg.
PD MAY-JUN
PY 2008
VL 23
IS 3
BP 227
EP 233
DI 10.1111/j.1540-8191.2008.00595.x
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 300PX
UT WOS:000255838800009
PM 18435637
DA 2026-07-24
ER
PT J
AU Reed, SF
   Novosel, TJ
   Weireter, LJ
   Collins, JN
   Britt, RC
   Alvey, C
   Merkh, K
   Britt, LD
AF Reed, Scott F.
   Novosel, Timothy J.
   Weireter, Leonard J.
   Collins, Jay N.
   Britt, Rebecca C.
   Alvey, Corrine
   Merkh, Kathy
   Britt, L. D.
TI A novel technique for vacuum assisted closure on injured tissue or in
   confined spaces
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
C1 [Reed, Scott F.; Novosel, Timothy J.; Weireter, Leonard J.; Collins, Jay N.; Britt, Rebecca C.; Britt, L. D.] Eastern Virginia Med Sch, Norfolk, VA 23507 USA.
   [Alvey, Corrine; Merkh, Kathy] Sentara Norfolk Gen Hosp, Norfolk, VA USA.
C3 Eastern Virginia Medical School; Sentara Healthcare
RP Reed, SF (通讯作者)，Eastern Virginia Med Sch, 825,Fairfax Ave 610, Norfolk, VA 23507 USA.
EM reedsf@evms.edu
RI Ivic, Rebecca Katherine/AFK-0661-2022
OI Ivic, Rebecca Katherine/0000-0002-4595-4604
NR 0
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD MAY
PY 2008
VL 64
IS 5
BP 1406
EP 1407
DI 10.1097/TA.0b013e318150733c
PG 2
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 301SH
UT WOS:000255915400046
PM 18469668
DA 2026-07-24
ER
PT J
AU Liguori, PA
   Peters, KL
   Bowers, JM
AF Liguori, Paul A.
   Peters, Kim L.
   Bowers, Jolene M.
TI Combination of negative pressure wound therapy and acoustic pressure
   wound therapy for treatment of infected surgical wounds: A case series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE acoustic pressure wound therapy; negative pressure wound therapy;
   surgical wounds; wound infection; debridement
ID ULTRASOUND THERAPY; VACUUM
AB The optimal wound therapy for healing infected wounds post surgery or surgical debridement has not been established. Negative pressure wound therapy and acoustic pressure wound therapy are advanced wound-healing modalities that apply forms of mechanical pressure to wound tissue in an effort to promote healing by stimulating cellular proliferation. Using a combination of negative pressure wound therapy and acoustic pressure wound therapy was evaluated in a series of six patients with large, infected surgical wounds presenting with moderate to large amounts of serosanguineous drainage. After concurrent treatment with both modalities (range: 4 to 12 weeks), wound volume was reduced by 99% to 100% in all wounds except one wound for which depth at end of treatment was not measurable due to hypergranulation. Similarly, wound surface area was reduced by 82% to 100%, with the exception of the hypergranular wound, which decreased in size by 60%. Serosanguineous wound drainage was reduced in four wounds and remained unchanged in two wounds.
C1 [Liguori, Paul A.; Peters, Kim L.; Bowers, Jolene M.] Whittier Rehabil Hosp, Haverhill, MA USA.
RP Liguori, PA (通讯作者)，Whittier Rehabil Hosp, Haverhill, MA USA.
CR Ennis W, 2002, Wound Healing: Alternatives in Management, P68
   Ennis WJ, 2005, OSTOMY WOUND MANAG, V51, P24
   Gregor S, 2008, ARCH SURG-CHICAGO, V143, P189, DOI 10.1001/archsurg.2007.54
   Joseph E, 2000, WOUNDS, V12, P60
   Kavros Steven J, 2007, Adv Skin Wound Care, V20, P221, DOI 10.1097/01.ASW.0000266660.88900.38
   Lewis R, 2001, Health Technol Assess, V5, P1
   Singh Aparajita, 2004, Asian J Surg, V27, P326, DOI 10.1016/S1015-9584(09)60061-0
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Unger PG, 2008, OSTOMY WOUND MANAG, V54, P57
   Vermeulen H, 2005, BJS-BRIT J SURG, V92, P665, DOI 10.1002/bjs.5055
NR 10
TC 9
Z9 10
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAY
PY 2008
VL 54
IS 5
BP 50
EP 53
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 302IA
UT WOS:000255960800007
PM 18493094
DA 2026-07-24
ER
PT J
AU Olejnik, J
   Vokurka, J
   Vician, M
AF Olejnik, Juraj
   Vokurka, Jiri
   Vician, Marek
TI Acute necrotizing pancreatitis: Intra-abdominal vacuum sealing after
   necrosectomy
SO HEPATO-GASTROENTEROLOGY
LA English
DT Article
DE severe acute pancreatitis; acute necrotizing pancreatitis; infected
   pancreatic necrosis; pancreatic necrosectomy; intra-abdominal vacuum
   sealing; bursostomy; laparostomy
ID OPEN ABDOMEN; CLOSURE; MANAGEMENT
AB Background: Cases of acute pancreatitis with infected pancreatic necrosis warrant consideration of surgical interventions designed to achieve the goal of pancreatic debridement and drainage. Notable experience with the use of vacuum assisted closure for abdominal wall defects was an assumption for its peripancreatic application after debridement in septic patients with infected pancreatic necrosis confirmed by radiological evidence of gas or results of fine needle aspiration. The goal of this study was to evaluate our own experience with this new therapeutic technique.
   Methods: This study is a multi-center retrospective analysis and comparison of 2 groups of patients with severe sepsis and a proven pancreatic source of infection. Group A consisted of 67 patients, 42 men and 25 women with ages ranging from 19-90 years (mean 48.0), who were treated surgically between 2002 and 2006 using a combination of laparostomy, multiple irrigations and abdominal drainage. Group B consisted of 39 patients, 28 men and 11 women aged from 18-87 years (mean 51.8), who were treated between 2002 and 2006 using the former techniques with the addition of an intra-abdominal vacuum assisted negative pressure therapy system.
   Results: The number of repeat laparotomies with debridement of the open abdominal wound in general anesthesia in group A ranged from 5-18 over 10-33 days (median 21) of surgical treatment period. The number of repeat laparotomies in group B decreased to 3-9 and the surgical treatment period decreased to 9-29 days (median 16). Seventeen patients (25.4%) in group A died because of severe sepsis and multiple organ failure, compared to 7 patients (17.9%) in group B.
   Conclusion: Authors confirmed significant reduction of morbidity and mortality with the use of the intra-abdominal vacuum assisted system in the treatment of localized pancreatic source of sepsis.
C1 [Olejnik, Juraj; Vician, Marek] Slovak Med Univ, Derers Univ Hosp, Dept Surg, Bratislava, Slovakia.
   [Vokurka, Jiri] Masaryk Univ, St Anna Univ Hosp, Fac Med, Dept Surg 1, Brno, Czech Republic.
C3 Slovak Medical University Bratislava; St. Anne's University Hospital
   Brno (FNUSA); Masaryk University
RP Olejnik, J (通讯作者)，Slovak Med Univ, Derers Univ Hosp, Dept Gen Surg, Limbova 5, Bratislava 83305, Slovakia.
EM olejnik@chello.sk
CR Adam U, 1997, LANGENBECK ARCH CHIR, V382, pS18, DOI 10.1007/PL00014638
   Balthazar EJ, 2002, RADIOLOGY, V223, P603, DOI 10.1148/radiol.2233010680
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   BROCK WB, 1995, AM SURGEON, V61, P30
   Büchler MW, 2000, ANN SURG, V232, P619
   Bui TD, 2006, AM J SURG, V192, P235, DOI 10.1016/j.amjsurg.2006.01.013
   De Waele JJ, 2004, CRIT CARE, V8, pR504, DOI 10.1186/cc2991
   Fabian TC, 2007, SURG CLIN N AM, V87, P73, DOI 10.1016/j.suc.2006.09.011
   Gloor B, 2001, ARCH SURG-CHICAGO, V136, P592, DOI 10.1001/archsurg.136.5.592
   Hallay J, 2001, HEPATO-GASTROENTEROL, V48, P1488
   Holzheimer RG, 2001, EUR J MED RES, V6, P161
   Labler L, 2004, ZBL CHIR, V129, pS14, DOI 10.1055/s-2004.822668
   Nathens AB, 2004, CRIT CARE MED, V32, P2524, DOI 10.1097/01.CCM.0000148222.09869.92
   OLEJNIK J, 2004, LEK OBZOR, V53, P261
   Pupelis G, 2001, NUTRITION, V17, P91, DOI 10.1016/S0899-9007(00)00508-6
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   Tautenhahn J, 2004, CHIRURG, V75, P492, DOI 10.1007/s00104-004-0844-6
NR 18
TC 9
Z9 13
U1 0
U2 4
PU H G E UPDATE MEDICAL PUBLISHING S A
PI ATHENS
PA PO BOX 17257, ATHENS GR-10024, GREECE
SN 0172-6390
J9 HEPATO-GASTROENTEROL
JI Hepato-Gastroenterol.
PD MAR-APR
PY 2008
VL 55
IS 82-83
BP 315
EP 318
PG 4
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 304YC
UT WOS:000256144000005
PM 18613356
DA 2026-07-24
ER
PT J
AU Patané, F
   Zingarelli, E
   Sansone, F
   Cappuccio, G
   Rinaldi, M
AF Patane, Francesco
   Zingarelli, Edoardo
   Sansone, Fabrizio
   Cappuccio, Gianfranco
   Rinaldi, Mauro
TI Vacuum-assisted sternal closure after a 'depression induced ischemic
   test' in severe mediastinitis
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Article
DE mediastinitis; sternal wound infection; vacuum assisted sternal closure
ID POSTSTERNOTOMY MEDIASTINITIS; MANAGEMENT
AB We present a case of a 71-year-old patient with arterial myocardial revascularization and postoperative course complicated with sternal wound diastasis and subsequent mediastinitis. The patient underwent double revision of the mediastinum: the first in 13th and the second in 27th with total sternectomy. Although the resulting external exposure of pericardial cavity and grafts is a contraindication for using vacuum-assisted closure (VAC), we used it after a 'depression induced ischemic test' (DIIT) to evaluate ischemic threshold. After the VAC therapy period (from 32nd to 112th postoperative day), the sternal wound was ready to close. We think that VAC-therapy is a safe and economic approach in the treatment of serious substance loss even with pericardial cavity and graft exposure.
C1 [Patane, Francesco; Zingarelli, Edoardo; Sansone, Fabrizio; Rinaldi, Mauro] San Giovanni Battista Hosp, Dept Cardiac Surg, I-10126 Turin, Italy.
   [Cappuccio, Gianfranco] Villa Serena Hosp, Div Cardiovasc Rehabil, Turin, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino; AOU San Giovanni
   Battista-Molinette
RP Patané, F (通讯作者)，San Giovanni Battista Hosp, Dept Cardiac Surg, C So Bramante 88, I-10126 Turin, Italy.
EM f_patane@hotmail.com
RI Patane, Francesco/AAW-9473-2021
OI Rinaldi, Mauro/0000-0002-7092-8619
CR Catarino PA, 2000, ANN THORAC SURG, V70, P1891, DOI 10.1016/S0003-4975(00)02173-1
   Cowan KN, 2005, ANN THORAC SURG, V80, P2205, DOI 10.1016/j.athoracsur.2005.04.005
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 6
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1558-2027
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD JUN
PY 2008
VL 9
IS 6
BP 622
EP 624
DI 10.2459/JCM.0b013e3282f226ee
PG 3
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 305UX
UT WOS:000256204400012
PM 18475132
DA 2026-07-24
ER
PT J
AU Landau, AG
   Hudson, DA
   Adams, K
   Geldenhuys, S
   Pienaar, C
AF Landau, Alex G.
   Hudson, Don A.
   Adams, Kevin
   Geldenhuys, Stuart
   Pienaar, Conrad
TI Full-thickness skin grafts: Maximizing graft take using negative
   pressure dressings to prepare the graft bed
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; AVASCULAR DEFECTS; WOUND CONTROL; CONTRACTION;
   FOUNDATION; SURVIVAL; STATE
AB Background: Full thickness skin grafts (FTSGs) remain a good option for resurfacing defects of the face, neck, and dorsum of the feet. It results in soft, pliable, functional skin with minimal contraction. However, FTSG may result in patchy or irregular "take" resulting in recurrent contractures and pigmentary discrepancies. This study examines the use of a negative pressure dressing (NPD) to increase FTSG take.
   Methods: Wounds resulting from trauma, postburn contracture release, and an excision of a congenital nevus were included in the study. The wounds were prepared by surgical excision or debridement. A NPD was then applied for a period of 7 days, at which time the wounds were inspected and, if there was sufficient granulation tissue, covered with a FTSG. If the wound had not yet granulated sufficiently another NPD was placed and reassessed in 7 days. The FTSGs were harvested from the groin and abdominal area exactly to the size of the defect. A sponge bolster dressing was then applied. The take of the FTSG was judged using a grid of 1 x 1-cm squares. The wounds were measured and the amount of graft take was calculated as a percentage of the wound size. Complications in both the wound as well as the donor sites were noted.
   Results: Twenty-four patients were included in the study. The mean age was 6 years (range 1-14 years), including 9 burn contracture excisions, 14 road traffic accident-related injuries, and 1 excision of a congenital nevus. The site involved was the foot (6 patients), ankle (9 patients), axilla (2 patients), forearm (4 patients), face (2 patients), and the neck (1 patient). The average surface area of the defect was 78 cm(2) (range 18-264 cm(2)). Groin skin was harvested in all the cases. The NPD was applied on average for 8 days (range 7-15 days). The mean graft take was 95% (range 70%-100%). Only 1 patient had significant graft loss of 30%. Donor site morbidity was low, attaining primary closure in all but 2. Mean follow-up was 9 months.
   Conclusion: The results of this study confirm that the use of NPD enhances FTSG take.
C1 [Landau, Alex G.; Hudson, Don A.; Adams, Kevin; Geldenhuys, Stuart; Pienaar, Conrad] Univ Cape Town, Groote Schuur Hosp, Dept Plast Surg, ZA-7925 Cape Town, South Africa.
C3 University of Cape Town
RP Hudson, DA (通讯作者)，Groote Schuur Hosp, Dept Plast & Reconstruct Surg, H53 OMB, ZA-7925 Cape Town, South Africa.
EM donald.hudson@uct.ac.za
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   BAUER BS, 1993, PLAST RECONSTR SURG, V92, P59, DOI 10.1097/00006534-199307000-00009
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   FELDMAN JJ, 1984, PEDIAT PLASTIC SURG, VP, P552
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   Iwuagwu FC, 1999, PLAST RECONSTR SURG, V103, P1198, DOI 10.1097/00006534-199904040-00015
   McGregor IA, 1989, FUNDAMENTAL TECHNIQU
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Netscher DT, 1996, PLAST RECONSTR SURG, V98, P1120, DOI 10.1097/00006534-199611000-00052
   Paletta CE, 2006, PLASTIC SURG
   Patterson I, 2006, PLAST RECONSTR SURG, V118, P1551, DOI 10.1097/01.prs.0000240809.75586.be
   PLACE MJ, 1997, GRABB SMITHS PLASTIC, V17
   RAYNELL A, 1952, BR J PLAST SURG, V5, P6
   Rhodes ND, 2001, BRIT J PLAST SURG, V54, P273, DOI 10.1054/bjps.2000.3540
   ROBINSON JB, 1999, SELECTED READ PLAST, V9, P1
   RUDOLPH R, 1973, SURG GYNECOL OBSTET, V136, P641
   RUDOLPH R, 1990, PLASTIC SURG, V221
   Stephenson AJ, 2000, BRIT J PLAST SURG, V53, P397, DOI 10.1054/bjps.2000.3335
   Ünal S, 2005, ANN PLAS SURG, V55, P102, DOI 10.1097/01.sap.0000164531.23770.60
   WRIGHT JK, 1980, PLAST RECONSTR SURG, V66, P428, DOI 10.1097/00006534-198066030-00019
NR 23
TC 31
Z9 38
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2008
VL 60
IS 6
BP 661
EP 666
DI 10.1097/SAP.0b013e318146c288
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 306QZ
UT WOS:000256264200016
PM 18520204
DA 2026-07-24
ER
PT J
AU Eneroth, M
   van Houtum, WH
AF Eneroth, Magnus
   van Houtum, William H.
TI The value of debridement and Vacuum-Assisted Closure (VAC) Therapy in
   diabetic foot ulcers
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Diabetic Foot
CY MAY 09-12, 2007
CL Noordwijkerhout, NETHERLANDS
DE diabetes; foot ulcers; debridement; VAC
ID PRESSURE WOUND THERAPY; MAGGOT THERAPY; DRESSINGS; TRIAL
AB Background Treatment of diabetic foot ulcers includes a number of different regimes such as glycaemic control, re-vascularization, surgical, local wound treatment, offloading and other non-surgical treatments. Although considered the standard of care, the scientific evidence behind the various debridements used is scarce. This presentation will focus on debridement and V.A.C. Therapy, two treatments widely used in patients with diabetes and foot ulcers.
   Methods A review of existing literature on these treatments in diabetic foot ulcers, with focus on description of the various types of debridements used, the principles behind negative pressure wound therapy (NPWT) using the V.A.C. Therapy system and level of evidence.
   Results Five randomized controlled trials (RCT) of debridement were identified; three assessed the effectiveness of a hydrogel as a debridement method, one evaluated surgical debridement and one evaluated larval therapy. Pooling the three hydrogel RCTs suggested that hydrogels are significantly more effective than gauze or standard care in healing diabetic foot ulcers. Surgical debridement and larval therapy showed no significant benefit. Other debridement methods such as enzyme preparations or polysaccharide beads have not been evaluated in RCTs of people with diabetes. More than 300 articles have been published on negative pressure wound therapy, including several small RCTs and a larger multi-centre RCT of diabetic foot ulcers. Negative pressure wound therapy seems to be a safe and effective treatment for complex diabetic foot wounds, and could lead to a higher proportion of healed wounds, faster healing rates, and potentially fewer re-amputations than standard care.
   Conclusions Although debridement of the ulcer is considered a prerequisite for healing of diabetic foot ulcers, the grade of evidence is quite low. This may be due to a lack of studies rather than lack of effect. Negative pressure wound therapy seems to be safe and effective in the treatment of some diabetic foot ulcers, although there is still only one well-performed trial that evaluates the effect. Copyright (C) 2008 John Wiley & Sons, Ltd.
C1 [Eneroth, Magnus] Malmo Univ Hosp, Dept Orthopaed, S-20502 Malmo, Sweden.
   [van Houtum, William H.] Spaarne Hosp Hoofddorp, Dept Internal Med, NL-2134 TM Hoofddorp, Netherlands.
C3 Lund University; Skane University Hospital; Spaarne Hospital
RP Eneroth, M (通讯作者)，Malmo Univ Hosp, Dept Orthopaed, S-20502 Malmo, Sweden.
EM magnus.eneroth@med.lu.se
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
   [Anonymous], 2002, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD003556
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Carlson E V, 1999, Am J Crit Care, V8, P262
   Cervo FA, 2000, GERIATRICS, V55, P55
   d'Hemecourt PA, 1998, WOUNDS, V10, P69
   Degreef HJ, 1998, DERMATOL CLIN, V16, P365, DOI 10.1016/S0733-8635(05)70019-X
   Eaglstein WH, 1997, SURG CLIN N AM, V77, P689, DOI 10.1016/S0039-6109(05)70575-2
   Edmonds M, 2000, DIABETES-METAB RES, V16, pS51, DOI 10.1002/1520-7560(200009/10)16:1+<::AID-DMRR142>3.0.CO;2-S
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Etöz A, 2004, WOUNDS, V16, P264
   Horch RE, 1998, CELL TRANSPLANT, V7, P309, DOI 10.1016/S0963-6897(98)00005-0
   Hunt TK, 1997, SURG CLIN N AM, V77, P587, DOI 10.1016/S0039-6109(05)70570-3
   Jensen WA, 1998, SEX PLANT REPROD, V11, P1, DOI 10.1007/s004970050113
   Joseph E, 2000, WOUNDS, V12, P60
   Jude EB, 2007, DIABETIC MED, V24, P280, DOI 10.1111/j.1464-5491.2007.02079.x
   Knowles A, 2001, Nurs Stand, V16, P73
   Maklebust J, 1996, Crit Care Nurs Clin North Am, V8, P141
   Markevich YO, 2000, DIABETOLOGIA, V43, pA15
   MCCALLON S.K., 2000, Ostomy Wound Manage, V46, P28
   McCardle Joanne E, 2006, Br J Nurs, V15, pS12
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Mumcuoglu KY, 1998, DIABETES CARE, V21, P2030, DOI 10.2337/diacare.21.11.2030
   Nemoto K, 2000, CHEMOTHERAPY, V46, P111, DOI 10.1159/000007264
   PHILBECK TE, 2001, HOME HLTH CARE CONSU, V8, P26
   Piaggesi A, 1998, DIABETIC MED, V15, P412, DOI 10.1002/(SICI)1096-9136(199805)15:5<412::AID-DIA584>3.0.CO;2-1
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   Schwien T, 2005, OSTOMY WOUND MANAG, V51, P47
   Sherman RA, 2003, DIABETES CARE, V26, P446, DOI 10.2337/diacare.26.2.446
   Sieggreen M Y, 1997, Adv Wound Care, V10, P32
   Steed DL, 1996, J AM COLL SURGEONS, V183, P61
   Vandeputte J., 1997, PRESENTATION CLIN TR, P50
   *WB SAUND CO, 1981, DORL ILL MED DICT
NR 34
TC 51
Z9 66
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAY-JUN
PY 2008
VL 24
SU 1
BP S76
EP S80
DI 10.1002/dmrr.852
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 308RS
UT WOS:000256408300016
PM 18393328
DA 2026-07-24
ER
PT J
AU Apelqvist, J
   Armstrong, DG
   Lavery, LA
   Boulton, AJM
AF Apelqvist, Jan
   Armstrong, David G.
   Lavery, Lawrence A.
   Boulton, Andrew J. M.
TI Resource utilization and economic costs of care based on a randomized
   trial of vacuum-assisted closure therapy in the treatment of diabetic
   foot wounds
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE amputation; wound; ulcer; infection; resource utilization; diabetes
ID ULCERS; AMPUTATION; MELLITUS
AB BACKGROUND: To evaluate resource utilization and direct economic costs of care for patients treated with negative-pressure wound therapy (NPWT), using the Vacuum-Assisted Closure (V.A.C.) system, compared to standard moist wound therapy (MWT).
   METHODS: A total of 162 diabetic patients with post-amputation wounds (up to the trans-metatarsal level) entered a 16-week, randomized clinical trial. Patients randomized to V.A.C. (n = 77) received therapy with dressing changes every 48 hours. Control patients (n = 85) received standard MWT. Resource utilization, procedures, and direct costs were calculated and analyzed in this post hoc retrospective study.
   RESULTS: There was no difference between groups for in-patient hospital stay (number of admissions or length of stay). More surgical procedures (including debridement) were required in the MWT group (120 vs 43 NPWT, P < .001). The average number of dressing changes performed per patient was 118.0 (range 12-226) for MWT versus 41 (6-140) for NPWT (P = .0001). The MWT group had 11 (range 0-106) outpatient treatment visits during the study versus 4 (range 0-47) in the NPWT group (P < .05). The average direct cost per patient treated for 8 weeks or longer (independent of clinical outcome) was $27,270 and $36,096 in the NPWT and MWT groups, respectively. The average total cost to achieve healing was $25,954 for patients treated with NPWT (n = 43) compared with $38,806 for the MWT group (n = 33).
   CONCLUSION: Treatment of diabetic patients with post amputation wounds using NPWT resulted in lower resource utilization and a greater proportion of patients obtaining wound healing at a lower overall cost of care when compared to MWT. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Armstrong, David G.] Rosalind Franklin Univ Med & Sci, Scholls Ctr Lower Extrem Ambulatory Res, Chicago, IL 60064 USA.
   [Apelqvist, Jan] Lund Univ, Div Clin Sci, Lund, Sweden.
   [Lavery, Lawrence A.] Texas A&M Univ, Dept Surg, Scott & White Hosp, Hlth Sci Ctr,Coll Med, Temple, TX USA.
   [Boulton, Andrew J. M.] Univ Miami, Miami, FL USA.
   [Boulton, Andrew J. M.] Manchester Royal Infirm, Univ Dept Med, Manchester M13 9WL, Lancs, England.
   [Apelqvist, Jan] Malmo Univ Hosp, Dept Endocrinol, Malmo, Sweden.
C3 Chicago Medical School; Rosalind Franklin University of Medicine &
   Science; Lund University; Texas A&M University System; Texas A&M
   University College Station; Texas A&M Health Science Center; University
   of Miami; University of Manchester; Lund University; Skane University
   Hospital
RP Armstrong, DG (通讯作者)，Rosalind Franklin Univ Med & Sci, Scholls Ctr Lower Extrem Ambulatory Res, 3333 Green Bay Rd, Chicago, IL 60064 USA.
EM david.armstrong@rosalindfranklin.edu
OI Lavery, Lawrence/0000-0002-7920-9952
CR Allenet B, 1999, DIABETOLOGIA, V42, pA308
   [Anonymous], 2004, WOUNDS, p3S
   Apelqvist J, 1998, Clin Podiatr Med Surg, V15, P21
   APELQVIST J, 1994, J INTERN MED, V235, P463, DOI 10.1111/j.1365-2796.1994.tb01104.x
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Armstrong DG, 1998, DIABETES CARE, V21, P855, DOI 10.2337/diacare.21.5.855
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Boulton AJM, 2005, LANCET, V366, P1719, DOI 10.1016/S0140-6736(05)67698-2
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Ghatnekar O, 2002, J Wound Care, V11, P70
   Ghatnekar O, 2001, PHARMACOECONOMICS, V19, P767, DOI 10.2165/00019053-200119070-00005
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Joseph E, 2000, WOUNDS, V12, P60
   MCCALLON SK, 2000, OSTOMY WOUND MANAG, V46, P282
   Moues C M, 2005, J Wound Care, V14, P224
   Persson U, 2000, Value Health, V3 Suppl 1, P39
   Ramsey SD, 1999, DIABETES CARE, V22, P382, DOI 10.2337/diacare.22.3.382
   Redekop WK, 2003, PHARMACOECONOMICS, V21, P1171, DOI 10.2165/00019053-200321160-00003
   Sibbald R Gary, 2003, Ostomy Wound Manage, V49, P52
   Tennvall GR, 2004, CLIN INFECT DIS, V39, pS132, DOI 10.1086/383275
   Tennvall GR, 2000, J DIABETES COMPLICAT, V14, P235
   Tennvall GR, 2000, PHARMACOECONOMICS, V18, P225, DOI 10.2165/00019053-200018030-00003
   Treweek S, 2006, J Wound Care, V15, P235
   *WOUND OST CONT NU, 2004, GUID MAN WOUNDS PAT, P57
NR 24
TC 125
Z9 152
U1 0
U2 24
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD JUN
PY 2008
VL 195
IS 6
BP 782
EP 788
DI 10.1016/j.amjsurg.2007.06.023
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 311FI
UT WOS:000256585700010
PM 18355797
DA 2026-07-24
ER
PT J
AU Willy, C
   Voelker, HU
   Engelhardt, M
AF Willy, Christian
   Voelker, Hans-Ulrich
   Engelhardt, Michael
TI Literature on the subject of vacuum therapy: Review and update 2006
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE vacuum therapy; vacuum-assisted closure; peer-reviewed literature;
   evidence-based medicine
ID EVIDENCE-BASED MEDICINE; ASSISTED CLOSURE; WOUND CONTROL
AB Introduction: Today, vacuum therapy can be regarded as established in routine clinical use. Many hundreds of reports on the subject of vacuum therapy have appeared in medical literature. This review intends to give an overview of the peer-reviewed literature published to date and its quality considering criteria of evidence-based medicine (EbM).
   Methods: Literature search (MEDLINE, EMBASE, Cochrane, extensive manual search); up to May 31, 2006; evidence level: Classification of the Oxford Centre for Evidence-based Medicine.
   Results: Five hundred and fifty peer-reviewed citations were identified. Impressive jump in the annual publication rate is found from the year 2000 onwards; continuous broadening of the fields of indications; over 85% of all reports are case reports/series (only n = 27; EbM level < 4). To date, most of the publications are by authors from the United States, Germany, United Kingdom, Austria, the Netherlands, Switzerland, France, and Sweden. 7.5% of all peer-reviewed articles investigate scientific back grounds.
   Discussion: The clinical significance of this therapy is underlined by an obviously continuously marked extension of the range of indications in all surgical fields, and even in extreme ages of the patients. There is a considerable deficit of basic pathophysiological research and well-designed studies. This "deficiency," however, when judged against the quality of the general medical literature, does not point to the poor efficacy or low benefit of vacuum therapy but should rather be seen as a symptom of the clinical practitioner's problems in dealing with modern aspects of the theoretical background of EbM.
C1 [Willy, Christian; Engelhardt, Michael] German Mil Hosp Ulm, Dept Surg, D-89081 Ulm, Germany.
   [Voelker, Hans-Ulrich] Univ Wurzburg, Inst Pathol, Wurzburg, Germany.
C3 Ulm University; Military Hospital Ulm; University of Wurzburg
RP Willy, C (通讯作者)，German Mil Hosp Ulm, Dept Surg, Oberer Eselsberg 40, D-89081 Ulm, Germany.
EM PDDrmedChristianWilly@Bundeswehr.org
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell Paul, 2006, J Tissue Viability, V16, P16
   Feinstein AR, 1997, AM J MED, V103, P529, DOI 10.1016/S0002-9343(97)00244-1
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Fleischmann W, 1992, Acta Orthop Belg, V58 Suppl 1, P227
   HORCH RE, 2006, ZENTRALBL CHIR, V131, P44
   Howes N, 1997, BRIT J SURG, V84, P1220
   Kiter E, 2003, ARCH ORTHOP TRAUM SU, V123, P82, DOI 10.1007/s00402-003-0501-4
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   ROTHENAICHER G, 2006, ZENTRALBL CHIR, V131, P182
   SACKETT DL, 1995, HEALTH ECON, V4, P249, DOI 10.1002/hec.4730040401
   SOLOMON MJ, 1995, SURGERY, V118, P459, DOI 10.1016/S0039-6060(05)80359-9
NR 12
TC 11
Z9 14
U1 0
U2 1
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 1863-9933
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD FEB
PY 2007
VL 33
IS 1
BP 33
EP 39
DI 10.1007/s00068-007-6143-4
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 313HV
UT WOS:000256732600006
PM 26815972
DA 2026-07-24
ER
PT J
AU Schimmer, C
   Sommer, SP
   Bensch, M
   Elert, O
   Leyh, R
AF Schimmer, C.
   Sommer, S. P.
   Bensch, M.
   Elert, O.
   Leyh, R.
TI Management of poststernotomy mediastinitis: Experience and results of
   different therapy modalities
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE poststernotomy mediastinitis; vacuum assisted closure; primary reclosure
   with suction/irrigation system
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND-INFECTION; PERISTERNAL THORACIC
   WALL; CARDIAC-SURGERY; BLOOD-FLOW; DRAINAGE
AB Background: Different primary treatment modalities have been utilized to treat poststernotomy mediastinitis (PM) following cardiac surgery.
   Methods: A literature survey using the key phrases "treatment of deep sternal wound infection" and "poststernotomy-mediastinitis" was performed. Furthermore, a questionnaire regarding the primary treatment of PM was distributed to all 79 German heart surgery centers.
   Results: The review of the literature shows that the current understanding is based purely on retrospective studies, not on evidence-based medicine. All 79 German heart centers replied to the questionnaire. Vacuum-assisted closure therapy (V.A.C.(R)) is used in 28/79 (35%) heart centers as the "first-line" treatment, 22/79 (28%) perform primary reclosure in conjunction with a double-tube irrigation/suction system, and in 29/79 (37%) German heart centers both treatment options were used according to the intraoperative conditions.
   Conclusions: As a primary treatment for PM two treatment modalities are currently in use: primary reclosure coupled with a double-tube suction/irrigation system versus V.A.C.(R) therapy. Since prospective randomized studies have not yet been performed, controlled clinical trials comparing both treatment modalities are pivotal to define the evidence for patients presenting with PM.
C1 [Schimmer, C.; Sommer, S. P.; Bensch, M.; Elert, O.; Leyh, R.] Univ Hosp, Dept Heart Surg, D-97080 Wurzburg, Germany.
C3 University of Wurzburg
RP Schimmer, C (通讯作者)，Univ Hosp, Dept Heart Surg, Oberdurrbacherstr 6, D-97080 Wurzburg, Germany.
EM Schimmer_c@klinik.uni-wuerzburg.de
OI Sommer, Sebastian-Patrick/0000-0002-9990-5330
CR Berg HF, 2000, ANN THORAC SURG, V70, P924, DOI 10.1016/S0003-4975(00)01524-1
   Catarino PA, 2000, ANN THORAC SURG, V70, P1891, DOI 10.1016/S0003-4975(00)02173-1
   Cowan KN, 2005, ANN THORAC SURG, V80, P2205, DOI 10.1016/j.athoracsur.2005.04.005
   De Feo M, 2001, EUR J CARDIO-THORAC, V19, P811, DOI 10.1016/S1010-7940(01)00676-5
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
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   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
NR 20
TC 31
Z9 34
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD JUN
PY 2008
VL 56
IS 4
BP 200
EP 204
DI 10.1055/s-2008-1038386
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 314WD
UT WOS:000256839000004
PM 18481237
DA 2026-07-24
ER
PT J
AU Schintler, MV
   Prandl, EC
AF Schintler, M. V.
   Prandl, E. -C.
TI Vacuum-assisted closure - what is evidence based?
SO EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
LA English
DT Article
DE vacuum-assisted closure; conventional wound treatment; randomised
   clinical trials; evidence-based medicine
ID PRESSURE WOUND THERAPY; SUBATMOSPHERIC PRESSURE; NEGATIVE-PRESSURE;
   BASIC RESEARCH; FOUNDATION; INJURY; STATE
AB Background: VAC - vacuum-assisted closure, synonymous with TNP ( topical negative pressure) or VT ( Vacuum therapy) is a mode of therapy used to encourage wound healing. It is used both as primary treatment of chronic and complex wounds and as an adjunct for temporary closure and wound bed preparation preceding surgical procedures such as skin grafts and flap surgery. The device has come into wide and successful use although the physiological basis of its effect is not yet understood and few evidence-based data are available.
   Methods: A meta-analysis was made of peer-reviewed publications (PubMed-Medline) chosen on the basis of inclusion of the terms, randomised clinical trials, vacuum-assisted closure, and topical negative pressure.
   Results: Scientific data were evaluated from experimental animal studies, randomised clinical trials, observations of clinical applications and case reports on all known effects of VAC therapy. Systematic analysis of the data shows efficacy concerning induction of wound-healing mechanisms, especially in the early stage. Increased perfusion can be considered proven. Data analysis shows positive efficacy for the treatment of infection.
   Conclusions: Although this therapy appears effective, its superiority to conventional techniques has not been demonstrated. Because its mechanisms of action remain unclear, and as there is a gap between evidence-based data and the excellent clinical results, further prospective randomised blinded studies are needed. Even so, we conclude that VT ( vacuum therapy), used when indicated especially by experienced surgeons, is an excellent tool to support wound healing.
C1 [Schintler, M. V.; Prandl, E. -C.] Med Univ Graz, Dept Surg, Div Plast Surg, A-8036 Graz, Austria.
C3 Medical University of Graz
RP Schintler, MV (通讯作者)，Med Univ Graz, Dept Surg, Div Plast Surg, Auenbruggerpl 29, A-8036 Graz, Austria.
EM michael.schintler@meduni-graz.at
CR ADAMS TST, 2004, TOPICAL NEGATIVE PRE
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 45
TC 7
Z9 7
U1 0
U2 2
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 1682-8631
J9 EUR SURG
JI Eur. Surg.
PD FEB
PY 2008
VL 40
IS 1
BP 11
EP 18
DI 10.1007/s10353-008-0381-5
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 315GA
UT WOS:000256865000003
DA 2026-07-24
ER
PT J
AU Nishimura, K
   Kanaoka, Y
   Harada, S
   Saiki, M
   Marumoto, A
   Nakamura, Y
   Nishimura, M
AF Nishimura, Kengo
   Kanaoka, Yasushi
   Harada, Shingo
   Saiki, Munehiro
   Marumoto, Akira
   Nakamura, Yoshinobu
   Nishimura, Motonobu
TI Vacuum-assisted closure (VAC) for bilateral severe ischemic foot after
   revascularization: A patient report
SO YONAGO ACTA MEDICA
LA English
DT Article
DE peripheral aortic disease; severe ischemic foot; vacuum-assisted closure
ID WOUND CONTROL
AB The Vacuum-Assisted Closure (VAC) Therapy (KCI, San Antonio, TX) is a unique system that helps promote wound healing. We report a case of severe ischemic foot in which VAC therapy markedly improved wound healing. A 73-year-old man underwent left axillopopliteal bypass and left 3rd, 4th and 5th digital amputations for gangrene. Although his amputation stumps were complicated with methicillin-resistant Staphylococcus aureus (MRSA) infection, the stumps were successfully healed by VAC. He also had gangrene in his right 1st toe, which could not healed by VAC alone, and we performed right femoropopliteal bypass and right 1st digital amputation. The stump with MRSA infection was also successfully healed by VAC. Histopathologic examination revealed a lot of microvessels in the increased granulation tissue.
C1 [Nishimura, Kengo; Kanaoka, Yasushi; Harada, Shingo; Saiki, Munehiro; Marumoto, Akira; Nakamura, Yoshinobu; Nishimura, Motonobu] Tottori Univ, Fac Med, Dept Surg, Div Organ Regenerat Surg,Sch Med, Yonago, Tottori 6838054, Japan.
C3 Tottori University
RP Nishimura, K (通讯作者)，Tottori Univ, Fac Med, Dept Surg, Div Organ Regenerat Surg,Sch Med, Yonago, Tottori 6838054, Japan.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
NR 8
TC 1
Z9 1
U1 0
U2 1
PU TOTTORI UNIV, FACULTY MEDICINE
PI YONAGO
PA 86 NISHI-CHO, YONAGO, TOTTORI-KEN 683-8503, JAPAN
SN 0513-5710
J9 YONAGO ACTA MED
JI Yonago Acta Med.
PD MAR
PY 2008
VL 51
IS 1
BP 11
EP 15
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 315ST
UT WOS:000256900700002
DA 2026-07-24
ER
PT J
AU Rhode, JM
   Burke, WM
   Cederna, PS
   Haefner, HK
AF Rhode, Jennifer M.
   Burke, William M.
   Cederna, Paul S.
   Haefner, Hope K.
TI Outcomes of surgical management of stage III vulvar hidradenitis
   suppurativa
SO JOURNAL OF REPRODUCTIVE MEDICINE
LA English
DT Article; Proceedings Paper
CT 19th World Congress of the
   International-Society-for-the-Study-of-Vulvovaginal-Disease
CY JUL 28-AUG 04, 2007
CL Juneau, AK
SP Int Soc Study Vulvovaginal Dis
DE hidradenitis suppurativa; skin graft; vulvar diseases; vulvectomy
ID VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE DRESSINGS; CARBON-DIOXIDE
   LASER; SUBATMOSPHERIC PRESSURE; SKIN-GRAFTS; 10-YEAR EXPERIENCE; WOUND
   CONTROL; EXCISION; INFLIXIMAB; PATHOGENESIS
AB OBJECTIVE: To review prior experiences and outcomes of patients treated for stage III vulvar hidradenitis suppurativa (HS) and determine postoperative patient satisfaction.
   STUDY DESIGN. Patients managed surgically for stage III vulvar HS at University of Michigan Health Systems (January 2000 to December 2005) were identified. Retrospective record review was undertaken and data collected. Five met study criteria. All underwent radical vulvectomy to excise the HS. Most required extensive excision of the vulva, including mons, perianal area and buttock. One surgical defect was allowed to heal by secondary intention; all others underwent interval closure with split-thickness skin grafting (STSG). After debridement, all wounds were dressed with a vacuum assisted closure device.
   RESULTS: Of the 5 patients, 4 were satisfied with their outcome. The patient managed without STSG developed an introital stricture and was the only patient regretting undergoing surgical excision of the hidradenitis suppurativa. Some amount of depression was present in all patients postoperatively. Four were happy with the surgery; 3 said they would undergo surgery again.
   CONCLUSION: Patients with severe HS often require radical excision. Data conflict regarding optimal surgical management. Our experience supports good outcome in patients managed with radical excision and STSG.
C1 Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA.
   Columbia Univ, Med Ctr, Dept Obstet & Gynecol, New York, NY USA.
   Wright Patterson Med Ctr, Dept Obstet & Gynecol, Wright Patterson AFB, OH USA.
C3 University of Michigan System; University of Michigan; Columbia
   University
RP Haefner, HK (通讯作者)，Univ Michigan, Med Ctr, Womens Hosp L 4000, Dept Obstet & Gynecol, 1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM haefner@med.umich.edu
RI Burke, William/AAI-9265-2020
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NR 58
TC 19
Z9 20
U1 0
U2 2
PU SCI PRINTERS & PUBL INC
PI ST LOUIS
PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA
SN 0024-7758
EI 1943-3565
J9 J REPROD MED
JI J. Reprod. Med.
PD JUN
PY 2008
VL 53
IS 6
BP 420
EP 428
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Obstetrics & Gynecology
GA 317NC
UT WOS:000257025900009
PM 18664060
DA 2026-07-24
ER
PT J
AU Geiger, S
   McCormick, F
   Chou, R
   Wandel, AG
AF Geiger, Scott
   McCormick, Frank
   Chou, Richard
   Wandel, Amy G.
TI War wounds: Lessons learned from Operation Iraqi Freedom
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID INJURIES; RECONSTRUCTION
AB Background: This study reports the experience of the plastic surgery department at Naval Medical Center San Diego in treating wounds resulting from combat during Operation Iraqi Freedom. Introduction of new technology and modification of medical treatments have emerged to provide greater success in preserving life and limb.
   Methods: The authors conducted a retrospective review of all Navy and Marine Corps casualties treated by the authors' department between April of 2003 and December of 2005. All medical information surrounding the patients' treatment and medivac rosters were used to collect the data.
   Results: The authors treated 68 patients, who underwent 240 operations. The age distribution was consistent with military enlistments (19 to 38 years). The majority of injuries were from blast (55 percent) and gunshot wounds (19 percent). The extremities were the site of injury in 9.1.2 percent of patients, with lower extremity wounds outnumbering upper extremity wounds approximately 2:1. The authors' wound management technique incorporated an aggressive surgical and antibiotic protocol, antibiotic-impregnated beads, and wound vacuum-assisted closure. The authors' limb salvage rate was high at 93.6 percent, with three amputations performed for flap failure. The acute osteomyelitis rate was 24.2 percent and the chronic osteomyelitis rate was 1.6 percent.
   Conclusions: The authors' results reflect a higher limb salvage rate than that achieved during previous wars. They feel their success was attributable to the use of wound vacuum-assisted closure, an aggressive surgical approach, and appropriate antibiotic therapy. Wound vacuum-assisted closure is the single intervention that is new among the authors' choices of techniques for treating combat wounds.
C1 [Geiger, Scott; McCormick, Frank; Chou, Richard; Wandel, Amy G.] USN, Med Ctr, Dept Plast Surg, San Diego, CA 92152 USA.
C3 United States Department of Defense; United States Navy
RP Wandel, AG (通讯作者)，3160 Folsom Blvd, Sacramento, CA 95816 USA.
EM ghhartman@comcast.net
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NR 19
TC 68
Z9 85
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUL
PY 2008
VL 122
IS 1
BP 146
EP 153
DI 10.1097/PRS.0b013e3181773d19
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 318PO
UT WOS:000257104300018
PM 18594399
DA 2026-07-24
ER
PT J
AU Schneiter, D
   Grodzki, T
   Lardinois, D
   Kestenholz, PB
   Wojcik, J
   Kubisa, B
   Pierog, J
   Weder, W
AF Schneiter, Didier
   Grodzki, Tomasz
   Lardinois, Didier
   Kestenholz, Peter B.
   Wojcik, Janusz
   Kubisa, Bartosz
   Pierog, Jaroslaw
   Weder, Walter
TI Accelerated treatment of postpneumonectomy empyema: A binational
   long-term study
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Association-for-Thoracic-Surgery
CY MAY 05-09, 2007
CL Washington, DC
SP Amer Assoc Thorac Surg
ID BRONCHOPLEURAL FISTULA; CLAGETT PROCEDURE; MANAGEMENT; IRRIGATION;
   CLOSURE
AB Objective: Postpneumonectomy empyema remains a clinical challenge. We proposed an accelerated therapy without an open chest window 5 years ago. This concept was evaluated on a larger scale in 2 centers in 2 different countries.
   Methods: Between July 1995 and October 2005, 75 consecutive patients with postpneumonectomy empyema were treated in Szczecin, Poland ( n = 35), and Zurich, Switzerland ( n 5 40). The therapy consisted of repeated open surgical debridement of the pleural cavity after achievement of general anesthesia, a negative pressure wound therapy of the temporarily closed chest cavity filled with povidone-iodine soaked towels, and continuous suction and systemic antimicrobial therapy. If present, bronchopleural fistulae were closed and reinforced either with a muscle flap or the omentum. Finally, the pleural space was filled with an antibiotic solution and definitively closed.
   Results: Of 75 patients ( 63 men; median age, 59 years; age range, 19 - 82 years), postpneumonectomy empyema was present on the right in 46 patients ( 32 with bronchopleural fistula) and in 29 patients ( 12 with bronchopleural fistula) on the left. Median time between pneumonectomy and postpneumonectomy empyema was 131 days ( range, 7 - 7200 days). Bronchopleural fistulae have been closed and additionally reinforced by means of different methods ( omentum, 18; muscle, 11; pericardial fat, 5; azygos vein, 1). The chest was definitively closed within 8 days in 94.6% of patients. The median hospitalization time was 18 days ( range, 9 - 134 days). Postpneumonectomy empyema was successfully treated in 97.3% of patients, including 10 ( 13%) patients who needed a second treatment cycle. Three ( 4%) patients died within 90 days. The median follow-up time was 29.5 moths ( range, 3 - 107 months).
   Conclusions: Treatment of postpneumonectomy empyema with the accelerated treatment is effective and safe. Our results are superior compared with those in reported series using a ( temporary) chest fenestration. Patients appreciate the physical integrity of the chest.
C1 [Weder, Walter] Univ Zurich Hosp, Div Thorac Surg, CH-8091 Zurich, Switzerland.
   [Grodzki, Tomasz; Wojcik, Janusz; Kubisa, Bartosz; Pierog, Jaroslaw] Pomeranian Med Univ, Szczecin Zdunowo, Poland.
C3 University of Zurich; University Zurich Hospital; Pomeranian Medical
   University
RP Weder, W (通讯作者)，Univ Zurich Hosp, Div Thorac Surg, CH-8091 Zurich, Switzerland.
EM walter.weder@usz.ch
RI Wójcik, Janusz/HNI-1040-2023
OI Kubisa, Bartosz/0000-0003-1226-7020
CR Abbas AE, 2002, CURR OPIN PULM MED, V8, P327, DOI 10.1097/00063198-200207000-00015
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NR 19
TC 65
Z9 73
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD JUL
PY 2008
VL 136
IS 1
BP 179
EP 185
DI 10.1016/j.jtcvs.2008.01.036
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 322OT
UT WOS:000257385900026
PM 18603072
OA Bronze
DA 2026-07-24
ER
PT J
AU Marchaland, JP
   Bey, E
   Paranque, A
   Ollat, D
   Boddaert, G
   Versier, G
AF Marchaland, J. -P.
   Bey, E.
   Paranque, A.
   Ollat, D.
   Boddaert, G.
   Versier, G.
TI First treatment of distal loss of tissue on lower limbs. About 15 cases
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE loss of tissue; foot; ankle; trauma; wound heating; reconstructive
   surgery; pediled faciocutaneous flaps
ID FREE FLAPS; RECONSTRUCTION; MANAGEMENT; FRACTURES; INJURIES
AB Distal extremity of Lower limb sustains the complications of loss of tissue: problem of coverage (cutaneous and tendon necrosis, osteoarticutar infection. The whole point of the surgery is to fight against the infection by repeated debridments, against the deformations or their correction by early osteosynthesis (pins and external fixation). The coverage is very important in this treatment: either with Vacuum-Assisted Closure (VAC (R)) and skin graft or fasciocutaneous flap. In spite of this management, the after-effects are important although the conservative treatment is the determining factor of satisfaction. (C) 2007 Elsevier Masson SAS. Tous droits reserves.
C1 [Marchaland, J. -P.; Ollat, D.; Boddaert, G.; Versier, G.] HIA Begin, Serv Chirurg Orthoped & Traumatol, F-94160 St Mande, France.
   [Bey, E.] HIA Percy, Serv Chirurg Plast & Reconstructrice, F-92140 Clamart, France.
   [Paranque, A.] HIA Begin, Serv Chirurg Maxillofaciale & Stomatol, F-94160 St Mande, France.
RP Marchaland, JP (通讯作者)，HIA Begin, Serv Chirurg Orthoped & Traumatol, 69 Ave Paris, F-94160 St Mande, France.
EM jpmarchaland@voila.fr
RI BODDAERT, Guillaume/MKF-0045-2025
OI BODDAERT, Guillaume/0000-0002-0536-3850
CR Belfkira F, 2006, Ann Chir Plast Esthet, V51, P199, DOI 10.1016/j.anplas.2005.12.010
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   Kenzora J E, 1981, Foot Ankle, V1, P348
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   Page JC, 2005, WOUNDS, p9S
   Pinsolle V, 2006, J PLAST RECONSTR AES, V59, P912, DOI 10.1016/j.bjps.2005.11.037
   Riccio M, 2005, MICROSURG, V25, P272, DOI 10.1002/micr.20132
   Seibert Franz Josef, 2003, Clin Podiatr Med Surg, V20, P159, DOI 10.1016/S0891-8422(02)00057-5
   Shilt JS, 2004, J PEDIATR ORTHOPED, V24, P482, DOI 10.1097/01241398-200409000-00006
   VERSIER G, 2005, EMC
NR 18
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD FEB
PY 2008
VL 53
IS 1
BP 14
EP 21
DI 10.1016/j.anplas.2007.04.005
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 322WP
UT WOS:000257406300003
PM 17961899
DA 2026-07-24
ER
PT J
AU Ploumis, A
   Mehbod, AA
   Dressel, TD
   Dykes, DC
   Transfeldt, EE
   Lonstein, JE
AF Ploumis, Avraam
   Mehbod, Amir A.
   Dressel, Thomas D.
   Dykes, Daryll C.
   Transfeldt, Ensor E.
   Lonstein, John E.
TI Therapy of spinal wound infections using vacuum-assisted wound closure:
   Risk factors leading to resistance to treatment
SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES
LA English
DT Article
DE vacuum-assisted closure; spine; infection; instrumentation
ID POSTOPERATIVE INFECTIONS; INSTRUMENTATION; MANAGEMENT; SURGERY; FUSION;
   ADULTS; RECONSTRUCTION; SCOLIOSIS
AB Study Design: This study retrospectively reviewed spine surgical procedures complicated by wound infection and managed by a protocol including the use of vacuum-assisted wound closure (VAC).
   Objective: To define factors influencing the number of debridements needed before the final wound closure by applying VAC for patients with postoperative spinal wound infections.
   Summary of Background Data: VAC has been suggested as a safe and probably effective method for the treatment of spinal wound infections. The risk factors for infection resistance and need for debridement revisions after VAC placement are unknown.
   Methods: Seventy-three consecutive patients with 79 wound infections after undergoing spine surgery were studied (6 of them had recurrence of infection). All patients were taken to the operating room for irrigation and debridement under general anesthesia followed by placement of the VAC with subsequent delayed closure of the wound. Linear regression and t test were used to identify if the following variables were risk factors for the resistance of infection to VAC treatment: timing of clinical appearance of infection, depth of infection (deep or superficial), presence of instrumentation, positive culture for methicillin-resistant Staphylococcus aureus (MRSA) or more than 1 microorganism, age of the patient, and presence of other comorbidities.
   Results: There were 34 males and 39 females with an average age of 58.4 years (21 to 82). Once the VAC was initiated, there was an average of 1.4 procedures until and including closure of the wound. The wound was closed an average of 7 days (range 5 to 14) after the placement of the initial VAC on the wound. The average follow-up was 14 months (range 12 to 28). All of the patients but 2 achieved a clean, closed wound without removal of instrumentation at a minimum follow-up of I year. Sixty patients had implants (instrumentation or allograft) within the site of wound infection. Thirteen patients had a decompression with exposed dura. Sixty-four infections (81%) presented with a draining wound within the first 6 weeks postoperatively. Sixty-nine infections (87.3%) were deep below the fascia. There was no statistical significance (P > 0.05) of all tested risk factors for the resistance of infection to treatment with the VAC system. The parameter more related to repeat VAC procedures was the culture of MRSA or multiple bacteria.
   Conclusions: VAC therapy may be an effective adjunct in closing spinal wounds even after the repeat procedures. The MRSA or multibacterial infections seem to be most likely to need repeat debridements and VAC treatment before final wound closure.
C1 [Ploumis, Avraam; Mehbod, Amir A.; Dressel, Thomas D.; Dykes, Daryll C.; Transfeldt, Ensor E.; Lonstein, John E.] Twin Cities Spine Ctr, Minneapolis, MN 55414 USA.
RP Ploumis, A (通讯作者)，Twin Cities Spine Ctr, 913 E 26th St, Minneapolis, MN 55414 USA.
EM ploumis@med.auth.gr
RI ; /AAH-4169-2019
OI Ploumis, Avraam/0000-0002-6828-3196; 
CR Beiner John M, 2003, Neurosurg Focus, V15, pE14
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NR 20
TC 54
Z9 65
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1536-0652
J9 J SPINAL DISORD TECH
JI J. Spinal Disord. Tech.
PD JUL
PY 2008
VL 21
IS 5
BP 320
EP 323
DI 10.1097/BSD.0b013e318141f99d
PG 4
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 324UC
UT WOS:000257543900004
PM 18600140
DA 2026-07-24
ER
PT J
AU Poulakidas, S
   Kowal-Vern, A
AF Poulakidas, Stathis
   Kowal-Vern, Areta
TI Facilitating residual wound closure after partial graft loss with vacuum
   assisted closure therapy
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
AB Third degree burns require skin grafting. In most instances, if the graft becomes infected, it requires debridement of the site and re-grafting. The purpose of this report is to illustrate the successful healing of a skin graft using negative pressure wound therapy with silver impregnated foam and soft silicone wound contact layer in a 4% total body surface area burn of a lower extremity skin graft infected with Pseudomonas aerugenosa without regrafting. A 27-year-old Hispanic male sustained a gasoline flame burn and presented 72 hours postincident with right lower extremity cellulitis. After intravenous antibiotics, the area was grafted with a partial thickness sheet graft. At 9 days postoperatively, the patient developed a wound infection, with an eventual 40% graft loss and was started on a course of antibiotics. With continued graft loss, on the 22nd postoperative day, negative pressure wound therapy V.A.C.(TM) (Vacuum Assisted Closure-KCI, San Antonio, TX) with silver impregnated foam and soft silicone wound contact layer (Mepitel (TM), Molnlycke Health Care, Gothenburg, Sweden) were applied. The wound was completely re-epithelialized by 9 days. In combination with antibiotics, it was possible to treat a residual open wound and prevent the need for regrafting.
C1 [Poulakidas, Stathis; Kowal-Vern, Areta] Cook Cty Hosp, Dept Trauma, Chicago, IL 60612 USA.
C3 John H Stroger Junior Hospital Cook County
RP Poulakidas, S (通讯作者)，Sumner L Koch Burn Ctr, Room 3229,1901 W Harrison St, Chicago, IL 60612 USA.
CR AMBROSIO A, VAC GRANUFOAM DRESSI
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NR 16
TC 6
Z9 7
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2008
VL 29
IS 4
BP 663
EP 665
DI 10.1097/BCR.0b013e31817db8b6
PG 3
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 325OA
UT WOS:000257597000017
PM 18535475
DA 2026-07-24
ER
PT J
AU Mouës, CM
   van Toorenenbergen, AW
   Heule, F
   Hop, WC
   Hovius, SER
AF Moues, Chantal M.
   van Toorenenbergen, Albert W.
   Heule, Freerk
   Hop, Wim C.
   Hovius, Steven E. R.
TI The role of topical negative pressure in wound repair:: Expression of
   biochemical markers in wound fluid during wound healing
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CHRONIC LEG ULCERS; MATRIX-METALLOPROTEINASES;
   DIFFERENTIAL EXPRESSION; TISSUE INHIBITOR; THERAPY;
   MATRIX-METALLOPROTEINASE-9; ANGIOGENESIS; PROTEASES; ELASTASE
AB The clinical effects of topical negative pressure therapy (TNP) on wound healing are well described in numerous articles. While the mechanism(s) of action are not completely understood, it is postulated that reduction of local and interstitial tissue edema, increased perfusion of the (peri-) wound area, changed bacterial composition, and mechanical stimulation of the woundbed contribute to the clinical success. Our hypothesis is that with the removal of excessive fluid, proteolytic enzymes negatively influencing the healing process are removed. Our aim was to assess whether the concentrations of albumin, matrixmetalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase (TIMP-1) were different between wounds treated with TNP and conventional gauze therapy. We analyzed wound fluid samples of 33 wounds treated with either TNP therapy (n=15) or conventional therapy (n=18) on albumin, pro- and activated MMP-9, TIMP-1, and the ratio of total MMP-9/TIMP-1. Albumin levels were found to increase significantly in acute wounds compared with chronic wounds; however, no difference could be found on comparing TNP with conventional therapy. We did find significantly lower levels of pro-MMP-9 and lower total MMP-9/TIMP-1 ratio in TNP-treated wounds during the follow-up of 10 days. These data strongly suggest that TNP therapy influences the microenvironment of the wound.
C1 [Moues, Chantal M.; Hovius, Steven E. R.] Erasmus Univ, Med Ctr, Dept Plast Reconstruct & Hand Surg, NL-3000 CA Rotterdam, Netherlands.
   [van Toorenenbergen, Albert W.] Erasmus Univ, Med Ctr, Dept Clin Chem, NL-3000 CA Rotterdam, Netherlands.
   [Heule, Freerk] Erasmus Univ, Med Ctr, Dept Dermatol, NL-3000 CA Rotterdam, Netherlands.
   [Hop, Wim C.] Erasmus Univ, Med Ctr, Dept Epidemiol & Biostat, NL-3000 CA Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC
RP Mouës, CM (通讯作者)，Erasmus Univ, Med Ctr, Dept Plast Reconstruct & Hand Surg, POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM cmoues@hotmail.com
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NR 35
TC 62
Z9 71
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2008
VL 16
IS 4
BP 488
EP 494
DI 10.1111/j.1524-475X.2008.00395.x
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 326RF
UT WOS:000257675900004
PM 18638266
DA 2026-07-24
ER
PT J
AU Weidenhagen, R
   Gruetzner, KU
   Wiecken, T
   Spelsberg, F
   Jauch, KW
AF Weidenhagen, Rolf
   Gruetzner, Klaus Uwe
   Wiecken, Timm
   Spelsberg, Fritz
   Jauch, Karl-Walter
TI Endoscopic vacuum-assisted closure of anastomotic leakage following
   anterior resection of the rectum: a new method
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE endoscopic; closure; anastomotic; leakage; resection; rectum
ID WOUND CONTROL; RISK-FACTORS; COMPLICATIONS; MANAGEMENT; SURGERY
AB Background Conservative treatment of anastomotic leakage after anterior resection of the rectum seems to be possible in patients who have no occurrence of generalized peritonitis. This report describes a new method of endoscopic management of large anastomotic leakage in these patients.
   Method The main feature of this new method is the endoscopically assisted placement of an open-cell sponge connected to a vacuum device into the abscess cavity via an introducer device. The sponge system is changed every 48-72 h.
   Results Twenty-nine patients with an anastomotic leakage after anterior resection were treated with the endoscopic vacuum therapy. The total duration of endovac therapy was 34.4 +/- 19.4 days. The total number of endoscopic sessions per patient was 11.4 +/- 6.3. In 21 of the 29 patients, a protecting stoma was created at the primary operation. Four patients were treated successfully without the need of a secondary stoma. Definitive healing was achieved in 28 of the 29 patients.
   Conclusions Endoscopic vacuum-assisted closure is a new efficacious modality for treating anastomotic leakage following anterior resection due to an effective control of the septic focus. Further studies will show if it is possible to reduce the high mortality rate of patients with anastomotic leakage through the avoidance of surgical reinterventions while at the same time preserving the sphincter function.
C1 [Weidenhagen, Rolf; Wiecken, Timm; Spelsberg, Fritz; Jauch, Karl-Walter] Univ Munich, Dept Surg, Klinikum Grosshadern, D-81377 Munich, Germany.
   [Gruetzner, Klaus Uwe] Univ Witten Herdecke, Clin Visceral Vasc & Transplant Surg, Clin Cologne Merheim, D-51109 Cologne, Germany.
C3 University of Munich; Witten Herdecke University
RP Weidenhagen, R (通讯作者)，Univ Munich, Dept Surg, Klinikum Grosshadern, Marchioninistr 15, D-81377 Munich, Germany.
EM rolf.weidenhagen@med.uni-muenchen.de
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NR 29
TC 263
Z9 311
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD AUG
PY 2008
VL 22
IS 8
BP 1818
EP 1825
DI 10.1007/s00464-007-9706-x
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 327KK
UT WOS:000257727800012
PM 18095024
DA 2026-07-24
ER
PT J
AU Svensson, S
   Monsen, C
   Kölbel, T
   Acosta, S
AF Svensson, S.
   Monsen, C.
   Kolbel, T.
   Acosta, S.
TI Predictors for outcome after vacuum assisted closure therapy of
   peri-vascular surgical site infections in the groin
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE vacuum assisted closure; surgical site infection; synthetic vascular
   graft; groin
ID RANDOMIZED CONTROLLED-TRIAL; MUSCLE FLAP COVERAGE; GRAFT INFECTIONS;
   SYNTHETIC GRAFTS; PRESERVATION
AB Objectives: To assess outcomes (wound heating, amputation and mortality) after vacuum assisted closure (VAC (R)) therapy of peri-vascutar surgical site infections in the groin after arterial surgery.
   Design: Retrospective study.
   Materials: Thirty-three groins received VAC (R) therapy between August 2004 and December 2006 at Vascular Centre, Malmo University Hospital.
   Methods: Following surgical revision, VACO therapy was applied in the groin at a continuous topical negative pressure of 125 mm Hg. The median follow up time was 16 months.
   Results: Median age was 75 years. Twenty-three (70%) cases underwent surgery for lower limb ischaemia. Intestinal flora was present in 88% of the wound cultures. Median duration of VACO therapy was 20 days and 27 (82%) wounds heated within 55 days. One serious VAC (R) associated bleeding and three late false femoral artery aneurysms were reported. The median cost of VACO treatment was 2.7% of the in-hospital costs. Synthetic vascular graft infection (n = 21) was associated with adverse infection-retated events (n = 9; p = 0.012). Non-heating wounds were associated with amputation (p = 0.005) and death (p < 0.001).
   Conclusions: VAC (R) treated synthetic vascular graft infections in the groin were at a greater risk of developing infection-related complications. Non-heating surgical site infections after VAC (R) therapy were associated with amputation and death. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Svensson, S.; Monsen, C.; Kolbel, T.; Acosta, S.] Malmo Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
C3 Lund University; Skane University Hospital
RP Acosta, S (通讯作者)，Malmo Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
EM stefan.acosta@telia.com
RI Acosta, Stefan/JAX-3225-2023; Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798; Kölbel, Tilo/0000-0002-9962-0204;
   Acosta, Stefan/0000-0002-8895-6001
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 21
TC 68
Z9 70
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD JUL
PY 2008
VL 36
IS 1
BP 84
EP 89
DI 10.1016/j.ejvs.2007.12.020
PG 6
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 329GZ
UT WOS:000257856300016
PM 18294875
OA Bronze
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Malmsjö, M
   Gesslein, B
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjoe, Malin
   Gesslein, Bodil
   Ingemansson, Richard
TI Evaluation of continuous and intermittent myocardial topical negative
   pressure
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Article
DE collateral blood flow; ischemia; myocardium; topical negative pressure
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; ENDOTHELIAL GROWTH-FACTOR;
   STERNAL WOUND-INFECTION; PERISTERNAL THORACIC WALL;
   CORONARY-ARTERY-DISEASE; BYPASS GRAFT-SURGERY; BLOOD-FLOW; RISK-FACTORS;
   POSTSTERNOTOMY MEDIASTINITIS
AB Objective Topical negative pressure, commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in subcutaneous tissue and skeletal muscle. In wound therapy, intermittent negative pressure is often preferred to continuous negative pressure as tissue exposed to intermittent therapy shows twice as much granulation tissue formation than that exposed to continuous pressure after 2 weeks of therapy. The present study was designed to elucidate the differences in microvascular blood flow in the left anterior descending artery area between continuous and intermittent myocardial topical negative pressure of -50 mmHg.
   Methods Six pigs underwent median sternotomy. Laser Doppler probes were inserted horizontally into the heart muscle in the left anterior descending artery area at depths of approximately 5-6 mm. Measurements of microvascular blood flow were performed in normal myocardium and ischemic myocardium during 20 min of countinuous and intermittent topical negative pressure at -50 mmHg.
   Results Both continuous and intermittent topical negative pressure of -50 mmHg significantly increased microvascular blood flow in the underlying myocardium: from 56.2 +/- 13.1 perfusion units (PU) before to 132.8 +/- 7.4 PU during countinuous topical negative pressure application (P < 0.05) and from 75.8 +/- 12.1 PU before to 153.6 +/- 4.7 PU during intermittent topical negative pressure application (P < 0.05).
   Conclusion No statistically significant difference was found between microvascular blood flow during 20 min of continuous and intermittent topical negative pressure at -50 mmHg in this porcine model.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   [Malmsjoe, Malin; Gesslein, Bodil] Univ Lund Hosp, Dept Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Maljö, Malin/0000-0001-9849-9599;
   Ingemansson, Richard/0000-0001-7623-8953
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   Argenta LC, 1997, ANN PLAST SURG, V38, P577
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NR 37
TC 7
Z9 9
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD AUG
PY 2008
VL 9
IS 8
BP 813
EP 819
DI 10.2459/JCM.0b013e3282f85bda
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 331XS
UT WOS:000258046500010
PM 18607247
DA 2026-07-24
ER
PT J
AU Arigon, JP
   Chapuis, O
   Sarrazin, E
   Pons, F
   Bouix, A
   Jancovici, R
AF Arigon, J. -P.
   Chapuis, O.
   Sarrazin, E.
   Pons, F.
   Bouix, A.
   Jancovici, R.
TI Managing the open abdomen with Vacuum-assisted closure therapy:
   retrospective evaluation of 22 patients
SO JOURNAL DE CHIRURGIE
LA French
DT Article
DE open abdomen; laparostomy; vacuum-assisted wound closure; abdominal
   compartment syndrome; sepsis; abdominal trauma
ID ABDOMINAL COMPARTMENT SYNDROME; PLANNED VENTRAL HERNIA; FASCIAL CLOSURE;
   WOUND CLOSURE; OPEN MANAGEMENT; WALL DEFECTS; TRAUMA; SEPSIS;
   PERITONITIS; STATE
AB Background: The authors reviewed their experience in the management of "open abdomen" using the vacuum-assisted closure device (VAC (R)), in order to assess its morbidity particularly in terms of fistula, and the outcome of abdominal wall integrity.
   Methods: Between January 2003 and October 2006, 22 patients required management with an "open abdomen" technique (18 patients were managed with the VAC, abdominal dressing device with application of a specific sheet and 4 other patients simply required a dressing with the polyurethane sponge). The mean age was 55 years, and M/F sex ratio was 2.67. Indications were abdominal compartment syndrome in 7 patients, initial "abdominal closure" after trauma in one patient, severe abdominal sepsis in 7 patients, and abdominal wound dehiscence where closure was impossible in 7 patients.
   Results: There were no enteric fistulae. Two infections were seen - a chronic suppuration which resolved with antibiotic therapy and a deep abscess which was drained with radiologic guidance. Of the 18 cases of "open abdomen" managed with the VAC, 15 were alive. Six (40%) underwent a delayed primary closure at a mean interval of 9 days; the others underwent secondary healing by granulation, and 10 eventually underwent split thickness skin grafting at a mean interval of 50 days. With VAC closure of the "open abdomen", the development of ventral hernia is an anticipated outcome; in four cases, patients underwent abdominal wall reconstruction at an interval of one year.
   Conclusion: Laparostomy or "open abdomen" using the VACO dressing system should be considered an established and well-defined technique which provides temporary abdominal coverage with limited morbidity.
C1 [Arigon, J. -P.; Chapuis, O.; Sarrazin, E.; Pons, F.; Bouix, A.; Jancovici, R.] Hop Instruct Armees Percy, Serv Chirurg Thorac & Viscerale, F-92140 Clamart, France.
RP Arigon, JP (通讯作者)，Hop Instruct Armees Percy, Serv Chirurg Thorac & Viscerale, F-92140 Clamart, France.
EM jp.arigon@gmail.com
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NR 28
TC 14
Z9 15
U1 0
U2 3
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0021-7697
J9 J CHIR-PARIS
JI J. Chir.
PD MAY-JUN
PY 2008
VL 145
IS 3
BP 252
EP 261
DI 10.1016/S0021-7697(08)73755-4
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 332NJ
UT WOS:000258089400010
PM 18772734
DA 2026-07-24
ER
PT J
AU Glicenstein, J
AF Glicenstein, J.
TI Jules!Guerin (1801-1885) and wounds pneumatic occlusion.: A precursor of
   VAC®
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE wound treatment; wound dressing; history
ID VACUUM-ASSISTED CLOSURE
AB Vacuum-Assisted Closure System (R) (V.A.C.(R)), tested and introduced by MJ Morykwas and LC Argenta in 1977, is a wide-spread procedure used for the treatment of defects and chronic wounds. In the middle of the 19th century, a French surgeon tried hopelessly to convince the medical authorities by that time of the interest of a similar method. In 1844, Jules Guerin (1801-1885) imagined a process and described the technique and the results in the prestigious Academy of Medicine and Sciences in Paris in 1866 and 1867. Jules Guerin proposed to treat chronic wounds and defects by what he called "pneumatic occlusion". He proposed an apparatus with three parts: a process dressing applied to be wound a rubber occlusive membrane linked to an empty bell with a manometer. Jules Guerin presented his method with the indications, severed times at the Academy of Medicine. Results were detailed on complex wounds or amputations strumps. He explained with detail the action of the pneumatic occlusion but without taking on to account the role microorganisms and the absence of hygiene in infections. Unfortunately for him, his presentations were contemporary to the works of Pasteur and Lister. All surgeons privileged the use of antiseptics on wounds. The works of Jules Guerin were forgotten.(c) 2008 Elsevier Masson SAS.
RP Glicenstein, J (通讯作者)，63 Blvd Invalides, F-75007 Paris, France.
EM jglicenstein@free.fr
CR [Anonymous], 1794, GENTLEMANS MAGAZ OCT, P891
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   GUERIN J, 1867, CR HEBD ACAD SCI, V65, P1034
   MAISONNEUVE, 1867, COMPTES RENDUS SEANC, V65, P888
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   STROMEYER, 1838, TRAITE ANATOMIE CHIR, V1, P149
   STROMEYER, 1838, GAZ MED PARIS, V4, P673
NR 17
TC 1
Z9 4
U1 0
U2 0
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD AUG
PY 2008
VL 53
IS 4
BP 378
EP 382
DI 10.1016/j.anplas.2007.12.002
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 334DF
UT WOS:000258201800012
PM 18395314
DA 2026-07-24
ER
PT J
AU Peinemann, F
   McGauran, N
   Sauerland, S
   Lange, S
AF Peinemann, Frank
   McGauran, Natalie
   Sauerland, Stefan
   Lange, Stefan
TI Disagreement in primary study selection between systematic reviews on
   negative pressure wound therapy
SO BMC MEDICAL RESEARCH METHODOLOGY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUCTION DRAINAGE; RANDOMIZED-TRIAL; MANAGEMENT;
   QUALITY; INTERVENTIONS; STATEMENT; CAUTION
AB Background: Primary study selection between systematic reviews is inconsistent, and reviews on the same topic may reach different conclusions. Our main objective was to compare systematic reviews on negative pressure wound therapy ( NPWT) regarding their agreement in primary study selection.
   Methods: This retrospective analysis was conducted within the framework of a systematic review ( a full review and a subsequent rapid report) on NPWT prepared by the Institute for Quality and Efficiency in Health Care ( IQWiG). For the IQWiG review and rapid report, 4 bibliographic databases ( MEDLINE, EMBASE, The Cochrane Library, and CINAHL) were searched to identify systematic reviews and primary studies on NPWT versus conventional wound therapy in patients with acute or chronic wounds. All databases were searched from inception to December 2006. For the present analysis, reviews on NPWT were classified as eligible systematic reviews if multiple sources were systematically searched and the search strategy was documented. To ensure comparability between reviews, only reviews published in or after December 2004 and only studies published before June 2004 were considered. Eligible reviews were compared in respect of the methodology applied and the selection of primary studies.
   Results: A total of 5 systematic reviews ( including the IQWiG review) and 16 primary studies were analysed. The reviews included between 4 and 13 primary studies published before June 2004. Two reviews considered only randomised controlled trials ( RCTs). Three reviews considered both RCTs and non- RCTs. The overall agreement in study selection between reviews was 96% for RCTs ( 24 of 25 options) and 57% for non- RCTs ( 12 of 21 options). Due to considerable disagreement in the citation and selection of non- RCTs, we contacted the review authors for clarification ( this was not initially planned); all authors or institutions responded. According to published information and the additional information provided, most differences between reviews arose from variations in inclusion criteria or interauthor study classification, as well as from different reporting styles ( citation or non- citation) for excluded studies.
   Conclusion: The citation and selection of primary studies differ between systematic reviews on NPWT, particularly with regard to non- RCTs. Uniform methodological and reporting standards need to be applied to ensure comparability between reviews as well as the validity of their conclusions.
C1 [Peinemann, Frank; McGauran, Natalie; Lange, Stefan] Inst Qual & Efficiency Hlth Care IQWiG, D-51105 Cologne, Germany.
   [Sauerland, Stefan] Univ Witten Herdecke, Inst Res Operat Med, D-51109 Cologne, Germany.
C3 Witten Herdecke University
RP Peinemann, F (通讯作者)，Inst Qual & Efficiency Hlth Care IQWiG, Dillen Burger Str 27, D-51105 Cologne, Germany.
EM frank.peinemann@iqwig.de; n.mcgauran@iqwig.de;
   stefan.sauerland@ifomuni-wh.de; stefan.lange@iqwig.de
RI ; Peinemann, Frank/H-2800-2019
OI Sauerland, Stefan/0000-0003-1048-796X; Peinemann,
   Frank/0000-0002-4727-1313
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   2001, LEVELS EVIDENCE GRAD
   2006, NEGATIVE PRESSURE WO
   2007, NEGATIVE PRESSURE WO
NR 70
TC 16
Z9 17
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2288
J9 BMC MED RES METHODOL
JI BMC Med. Res. Methodol.
PD JUN 26
PY 2008
VL 8
AR 41
DI 10.1186/1471-2288-8-41
PG 16
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 335PM
UT WOS:000258302500001
PM 18582373
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ubbink, DT
   Westerbos, SJ
   Nelson, EA
   Vermeulen, H
AF Ubbink, D. T.
   Westerbos, S. J.
   Nelson, E. A.
   Vermeulen, H.
TI A systematic review of topical negative pressure therapy for acute and
   chronic wounds
SO BRITISH JOURNAL OF SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; RANDOMIZED-TRIAL;
   MANAGEMENT; ULCERS
AB Topical negative pressure (TNP) therapy is becoming increasingly popular for all kinds of wounds. Its clinical and cost effectiveness is unclear.
   A search of randomized controlled trials (RCTs) on TNP in adult patients with all kinds of wounds in all settings was undertaken in Medline, Embase, Cinahl (to October 2007) and the Cochrane Library (to issue 4,2007). Information was also sought from manufacturer of the VAC (R) device. Selection of trials for analysis, quality assessment, data abstraction and data synthesis were conducted by two authors independently. The primary endpoint was any measure of wound healing. Secondary endpoints were infection, pain, quality of life, oedema, microcirculation, bacterial load, adverse events, duration of hospital stay and cost.
   The search identified 15 publications on 13 RCTs. These reported on patients with chronic wounds, diabetic wounds, pressure ulcers, skin grafts and acute wounds. In chronic and diabetic wounds, TNP did not allow earlier complete wound healing. It was, however, associated with a 1-10 day reduction in the time needed to prepare the wound for secondary closure surgery. In one trial on acute wounds, 17 (95 per cent confidence interval (c.i.) 0.02 to 0.32) per cent more wounds appeared to heal with TNP; the number needed to treat was six. This was, however, at the cost of an It (95 per cent c.i. 0.01 to 0.21) per cent higher complication rate; the number needed to harm was nine.
   There is little evidence to support the use of TNP in the treatment of wounds.
C1 [Ubbink, D. T.] Univ Amsterdam, Acad Med Ctr, Dept Qual Assurance & Proc Innovat, NL-1100 DE Amsterdam, Netherlands.
   [Ubbink, D. T.] Univ Amsterdam, Acad Med Ctr, Dept Surg, NL-1100 DE Amsterdam, Netherlands.
   [Westerbos, S. J.] Univ Amsterdam, Dept Clin Epidemiol Biostat & Bioinformat, Acad Med Ctr, NL-1100 DE Amsterdam, Netherlands.
   [Nelson, E. A.] Univ Leeds, Sch Healthcare, Leeds, W Yorkshire, England.
   [Vermeulen, H.] Univ Amsterdam, Amsterdam Sch Nursing, NL-1100 DE Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam; University of
   Amsterdam; Academic Medical Center Amsterdam; University of Leeds;
   University of Amsterdam
RP Ubbink, DT (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Qual Assurance & Proc Innovat, Meibergdreef 9,Room J1B-215,POB 22700, NL-1100 DE Amsterdam, Netherlands.
EM D.Ubbink@amc.nl
RI Vermeulen, Hester/P-5739-2016; Ubbink, Dirk/AAF-1266-2021; Nelson,
   Andrea/K-2733-2012
OI Vermeulen, Hester/0000-0002-0743-2979; Ubbink, Dirk/0000-0001-9398-8879;
   Nelson, Andrea/0000-0001-6741-3078
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Etöz A, 2004, WOUNDS, V16, P264
   *EUR WOUND MAN ASS, TOP NEG PRESS WOUND
   Evans D, 2001, BRIT J PLAST SURG, V54, P238, DOI 10.1054/bjps.2001.3547
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   Joseph E, 2000, WOUNDS, V12, P60
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   MCCALLON S.K., 2000, Ostomy Wound Manage, V46, P28
   Mendonca Derick A, 2006, Int Wound J, V3, P261, DOI 10.1111/j.1742-481X.2006.00266.x
   Moher D, 2001, LANCET, V357, P1191, DOI 10.1016/S0140-6736(00)04337-3
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Mouës CM, 2007, J PLAST RECONSTR AES, V60, P672, DOI 10.1016/j.bjps.2006.01.041
   Moues C M, 2005, J Wound Care, V14, P224
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   NELSON EA, 2007, EWMA J, V7, P5
   Pham C T, 2006, J Wound Care, V15, P240
   Plikaitis CM, 2006, EXPERT REV MED DEVIC, V3, P175, DOI 10.1586/17434440.3.2.175
   Ruiz-Canela M, 2000, BMJ-BRIT MED J, V320, P1007, DOI 10.1136/bmj.320.7240.1007
   SCHULZ KF, 1995, JAMA-J AM MED ASSOC, V273, P408, DOI 10.1001/jama.273.5.408
   Ubbink DT, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001898.pub2
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
   Wasiak J, 2007, COCHRANE DATABASE SY
NR 30
TC 174
Z9 200
U1 0
U2 34
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD JUN
PY 2008
VL 95
IS 6
BP 685
EP 692
DI 10.1002/bjs.6238
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 336VA
UT WOS:000258391500004
PM 18446777
OA Bronze
DA 2026-07-24
ER
PT J
AU Bee, TK
   Croce, MA
   Magnotti, LJ
   Zarzaur, BL
   Maish, GO
   Minard, G
   Schroeppel, TJ
   Fabian, TC
AF Bee, Tiffany K.
   Croce, Martin A.
   Magnotti, Louis J.
   Zarzaur, Ben L.
   Maish, George O., III
   Minard, Gayle
   Schroeppel, Thomas J.
   Fabian, Timothy C.
TI Temporary abdominal closure techniques: A prospective randomized trial
   comparing polyglactin 910 mesh and vacuum-assisted closure
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article; Proceedings Paper
CT 66th Annual Meeting of the
   American-Association-for-the-Surgery-of-Trauma
CY SEP 27-29, 2007
CL Las Vegas, NV
SP Amer Assoc Surg Trauma
ID COMPARTMENT SYNDROME; OPEN ABDOMEN; PACK; MESH
AB Objective: The options for abdominal coverage after damage control laparotomy or abdominal compartment syndrome vary by institution, surgeon preference, and type of patient. Some advocate polyglactin mesh (MESH), while others favor vacuum-assisted closure (VAC). We performed a single institution prospective randomized trial comparing morbidity and mortality differences between MESH and VAC.
   Methods: Patients expected to survive and requiring open abdomen management were prospectively randomized to either MESH or VAC. After randomization, an enteral feeding tube was inserted and the closure device placed. VAC patients returned to the operating room every 3 days for a total of three changes at which time polyglactin mesh was placed if closure was not possible. The MESH group had twice daily assessments for the possibility of bedside mesh cinching and closure. Both groups underwent split thickness skin grafting when granulation tissue was evident, if delayed primary closure was not possible.
   Results: Fifty-one patients were randomized. Both cohorts were matched for Injury Severity Scale score, gender, blunt/penetrating/abdominal compartment syndrome and age. Three patients died within 7 days and were excluded from closure rate calculation. There were no differences between delayed primary fascial closure rates in the VAC (31%) or MESH (26%) groups. The fistula rate in the VAC group was 21 % but not statistically different from the 5% rate for MESH. Intraabdominal rates were not statistically different. All VAC fistulas were related to feeding tubes and suture line areas; the MESH fistula followed a retroperitoneal colon leak remote from the mesh.
   Conclusions: MESH and VAC are both useful methods for abdominal coverage, and are equally likely to produce delayed primary closure. The fistula rate for VAC is most likely due to continued bowel manipulation with VAC changes with a feeding tube in place-enteral feeds should be administered via nasojejunal tube. Neither method precludes secondary abdominal wall reconstruction.
C1 [Bee, Tiffany K.; Croce, Martin A.; Magnotti, Louis J.; Zarzaur, Ben L.; Maish, George O., III; Minard, Gayle; Schroeppel, Thomas J.; Fabian, Timothy C.] Univ Tennessee, Hlth Sci Ctr, Dept Surg, Memphis, TN 38163 USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center
RP Bee, TK (通讯作者)，Univ Tennessee, Hlth Sci Ctr, Dept Surg, 956 Court Ave,C208, Memphis, TN 38163 USA.
EM tbee@utmem.edu
RI ; Zarzaur, Ben/S-6572-2019
OI Schroeppel, Thomas/0000-0001-9164-5004; Zarzaur, Ben/0000-0001-9988-9572
CR Barker DE, 2007, J AM COLL SURGEONS, V204, P784, DOI 10.1016/j.jamcollsurg.2006.12.039
   BROCK WB, 1995, AM SURGEON, V61, P30
   Ciresi DL, 1999, AM SURGEON, V65, P720
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   VOYLES CR, 1981, ANN SURG, V194, P219, DOI 10.1097/00000658-198108000-00017
NR 10
TC 158
Z9 176
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD AUG
PY 2008
VL 65
IS 2
BP 337
EP 342
DI 10.1097/TA.0b013e31817fa451
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Surgery
GA 337US
UT WOS:000258461600019
PM 18695468
DA 2026-07-24
ER
PT J
AU Fredeking, AE
   Silverman, RA
AF Fredeking, Arden E.
   Silverman, Robert A.
TI Successful treatment of trigeminal trophic syndrome in a 6-year-old boy
   with negative pressure wound therapy
SO ARCHIVES OF DERMATOLOGY
LA English
DT Article
C1 [Fredeking, Arden E.; Silverman, Robert A.] Washington Hosp Ctr, Dept Dermatol, Washington, DC 20010 USA.
   [Fredeking, Arden E.; Silverman, Robert A.] Georgetown Univ Hosp, Div Dermatol, Washington, DC 20007 USA.
C3 MedStar Washington Hospital Center; Georgetown University
RP Fredeking, AE (通讯作者)，Washington Hosp Ctr, Dept Dermatol, 110 Irving St NW, Washington, DC 20010 USA.
EM arden04@gmail.com
CR Armstrong David G, 2007, Int Wound J, V4, P79, DOI 10.1111/j.1742-481X.2006.00270.x
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Sadeghi P, 2004, DERMATOL SURG, V30, P807, DOI 10.1111/j.1524-4725.2004.30220.x
   Setyadi HG, 2007, SOUTH MED J, V100, P43, DOI 10.1097/01.smj.0000253020.74133.7e
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   Tee RG, 2006, ARCH DERMATOL, V142, P941, DOI 10.1001/archderm.142.7.941
NR 14
TC 25
Z9 26
U1 0
U2 2
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0003-987X
J9 ARCH DERMATOL
JI Arch. Dermatol.
PD AUG
PY 2008
VL 144
IS 8
BP 984
EP 986
DI 10.1001/archderm.144.8.984
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 338JN
UT WOS:000258504100001
PM 18711069
DA 2026-07-24
ER
PT J
AU Keskin, M
   Karabekmez, FE
   Yilmaz, E
   Tosun, Z
   Savaci, N
AF Keskin, Mustafa
   Karabekmez, Furkan E.
   Yilmaz, Erkan
   Tosun, Zekeriya
   Savaci, Nedim
TI Vacuum-assisted closure of wounds and anxiety
SO SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND
   SURGERY
LA English
DT Article; Proceedings Paper
CT 5th Congress of the
   Balkan-Association-for-Plastic-Reconstructive-and-Aesthetic-Surgery
CY MAY 22-26, 2007
CL Izmir, TURKEY
SP Balkan Assoc Plast Reconstruct & Aesthet Surg
DE anxiety; pain; VAC
ID POSTTRAUMATIC-STRESS-DISORDER; SURGERY
AB The aim of this study was to investigate the degree of anxiety in patients in whom the vacuum-assisted closure (VAC) of wounds was used. Psychological evaluations were made on the day before VAC was applied and at the 10th day of treatment in 20 patients with traumatic wounds of the lower extremity. Anxiety was measured with the Hamilton Rating Scale for Anxiety and with the State Anxiety Inventory test. The same measurements were also made in 20 further patients with similar wounds but managed with classic treatment as controls. Both groups showed a significant increase in anxiety during the 10 days. The mean (SD) differences in the anxiety scores measured during the 10-day period were significantly higher in the group treated by VAC than in the control group, State Anxiety Inventory test (14.0 (2.3) compared with 2.6 (1.2), p < 0.001) and Hamilton Rating Scale for Anxiety test (4.4 (0.6) compared with 1.3 (0.6), p < 0.001). Although we think that VAC is an effective tool for treating lower extremity wounds, we have concerns about possible accompanying psychological effects.
C1 [Keskin, Mustafa; Karabekmez, Furkan E.; Tosun, Zekeriya; Savaci, Nedim] Univ Selcuk, Meram Med Fac, Dept Plast & Reconstruct Surg, TR-42080 Konya, Turkey.
   [Yilmaz, Erkan] Univ Selcuk, Meram Med Fac, Dept Psychiat, TR-42080 Konya, Turkey.
C3 Selcuk University; Selcuk University
RP Keskin, M (通讯作者)，Univ Selcuk, Meram Med Fac, Dept Plast & Reconstruct Surg, S Blok 211, TR-42080 Konya, Turkey.
EM drmkeskin@hotmail.com
RI Keskin, Mustafa/W-5938-2019; Savaci, Nedim/ABT-6759-2022; Karabekmez,
   Furkan/AAA-1820-2020
OI Keskin, Mustafa/0000-0003-2066-7454; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 13
TC 25
Z9 28
U1 0
U2 11
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0284-4311
J9 SCAND J PLAST RECONS
JI Scand. J. Plast. Reconstr. Surg. Hand Surg.
PY 2008
VL 42
IS 4
BP 202
EP 205
DI 10.1080/02844310802091586
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 342SS
UT WOS:000258804400007
PM 18763197
DA 2026-07-24
ER
PT J
AU Somanchi, BV
   Khan, S
AF Somanchi, Brinda Vihari
   Khan, Sohail
TI Vacuum-assisted wound closure (VAC) with simultaneous bone transport in
   the leg: A technical note
SO ACTA ORTHOPAEDICA BELGICA
LA English
DT Article
DE long bone fracture; non-union; bone transport; vacuum assisted wound
   closure
ID SOFT-TISSUE INJURIES; THERAPY; FRACTURES; RECONSTRUCTION; EXTREMITIES;
   MANAGEMENT; TRAUMA
AB Successful treatment of infected non union in long bone fractures has always been a challenge. Segmental excision followed by bone transport is one of the common modalities of treatment in such difficult cases. The soft tissue coverage of the resulting wounds was however not well described in the literature. The authors would like to report a simple technique that was used. After segmental bone excision and application of a ring fixator, a vacuum assisted closure (VAC) dressing was applied to the wound, which resulted in not only a remarkable growth of granulation tissue that filled the soft tissue defect, but also satisfactory signs of bony union across the docking site.
   The authors would like to emphasise the benefits of a simple method such as VAC therapy in enhancing cover of the large soft tissue defects during simultaneous bone transportation, and thus avoiding complex plastic surgical procedures.
C1 [Somanchi, Brinda Vihari; Khan, Sohail] Salford Royal Hosp, Salford, Lancs, England.
C3 Salford Royal NHS Foundation Trust; Salford Royal Hospital
RP Somanchi, BV (通讯作者)，3 Squires Court, Salford M5 5AD, Lancs, England.
EM brindavihari2001@yahoo.com
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Attinger C, 2001, ORTHOP CLIN N AM, V32, P135, DOI 10.1016/S0030-5898(05)70199-1
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NR 20
TC 2
Z9 2
U1 0
U2 0
PU ACTA MEDICA BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138-A, B-1180 BRUSSELS, BELGIUM
SN 0001-6462
J9 ACTA ORTHOP BELG
JI Acta Orthop. Belg.
PD AUG
PY 2008
VL 74
IS 4
BP 538
EP 541
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 344IS
UT WOS:000258920700019
PM 18811041
DA 2026-07-24
ER
PT J
AU Martin, DA
   Nanci, GN
   Marlowe, SI
   Larsen, AN
AF Martin, Deborah A.
   Nanci, Gabriella N.
   Marlowe, Steven I.
   Larsen, Alan N.
TI Necrotizing fasciitis with no mortality or limb loss
SO AMERICAN SURGEON
LA English
DT Article; Proceedings Paper
CT Annual Scientific Meeting and Postgraduate Course Program of the
   Southeastern-Surgical-Congress
CY FEB 09-12, 2008
CL Birmingham, AL
SP SE Surg Congress
ID RESISTANT STAPHYLOCOCCUS-AUREUS; STREPTOCOCCAL INFECTIONS; GANGRENE
AB Necrotizing fasciitis is a potentially lethal invasive soft tissue infection. Early aggressive antibiotic therapy and surgical debridement have been the hallmark of successful therapy. It is commonly held that delays in surgical debridement significantly increase the mortality rate and rate of limb loss. A mortality rate of 20 per cent or greater has been reported throughout the last 80 years. We recently reviewed the cases of 20 consecutive patients admitted to our hospital in various stages of necrotizing fasciitis progression. Treatment of all 20 patients consisted of antibiotic therapy and surgical debridement, with frequent follow-up serial debridement. Topical negative pressure was achieved with the use of the Vacuum Assisted Closure system. An aggressive surgical approach, (including the frequency of debridement, appropriate antibiotic utilization, and use of the Vacuum Assisted Closure system), significantly impacted our results, despite delays in treatment and progression of the infection.
C1 [Martin, Deborah A.; Nanci, Gabriella N.; Marlowe, Steven I.; Larsen, Alan N.] Northside Hosp, Atlanta, GA USA.
RP Martin, DA (通讯作者)，960 Johnson Ferry Rd,Sidle 143, Atlanta, GA 30342 USA.
EM dmartinmdfacs@bellsouth.net
RI Martins, Deborah/LRU-0382-2024
CR Anaya DA, 2005, ARCH SURG-CHICAGO, V140, P151, DOI 10.1001/archsurg.140.2.151
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NR 14
TC 6
Z9 6
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI ATLANTA
PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA
SN 0003-1348
J9 AM SURGEON
JI Am. Surg.
PD SEP
PY 2008
VL 74
IS 9
BP 809
EP 812
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 344NC
UT WOS:000258933400007
PM 18807667
DA 2026-07-24
ER
PT J
AU Scherer, SS
   Pietramaggiori, G
   Mathews, JC
   Prsa, MJ
   Huang, S
   Orgill, DP
AF Scherer, Sandra Saja
   Pietramaggiori, Giorgio
   Mathews, Jasmine C.
   Prsa, Michael J.
   Huang, Sui
   Orgill, Dennis P.
TI The mechanism of action of the vacuum-assisted closure device
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID WOUND THERAPY; CLINICAL-EXPERIENCE; CELL-PROLIFERATION; FOOT ULCERS;
   ANGIOGENESIS; PRESSURE; MATRIX; SKIN
AB Background: The vacuum-assisted closure device is widely used clinically, yet its mechanisms of action are incompletely understood. In this study, the authors designed a partially splinted full-thickness murine vacuum-assisted closure model to better understand the mechanism of action of the vacuum-assisted closure device.
   Methods: Full-thickness wounds (n = 1.0 per group) were excised in diabetic mice and treated with the vacuum-assisted closure device or its isolated components: an occlusive dressing, subatmospheric pressure at 125 mmHg (suction), and a polyurethane foam without and with downward compression. Results were quantified with a two-dimensional immunohistochemical staging system based on blood vessel density (CD31) and cell proliferation (Ki67) 7 days after wounding. Microscopic strain was measured by fixing in situ all dressing modalities.
   Results: Wounds exposed to polyurethane foam in compressed and uncompressed dressings or to the vacuum-assisted closure device showed a 2-fold increase in vascularity compared with the occlusive dressing group (p < 0.05). The vacuum-assisted closure device in addition stimulated cell proliferation, with Lip to 82 percent Ki67-positive nuclei, compared with the other groups. Direct measurements of wound surface deformations showed significant microstrains in the vacuum-assisted closure and foam in compressed dressing groups (60 percent and 16 percent, respectively) compared with all other groups.
   Conclusions: These data provide profound insights into the mechanism of action of the vacuum-assisted closure device, providing an explanation for the increases in wound bed vascularity and cell proliferation based on its components. Results suggest that the vascular response is related to the polyurethane foam, whereas tissue strains induced by the vacuum-assisted closure device Stimulated cell proliferation.
C1 [Orgill, Dennis P.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Childrens Hosp, Dept Pathol & Surg, Boston, MA 02115 USA.
   Heidelberg Univ, BG Unfallklin Ludwigshafen, Div Plast & Reconstruct Surg, D-6900 Heidelberg, Germany.
   Univ Geneva, Div Plast Surg, CH-1211 Geneva 4, Switzerland.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital; Harvard
   Medical School; Ruprecht Karls University Heidelberg; University of
   Geneva
RP Orgill, DP (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI PIETRAMAGGIORI, Giorgio/HJA-1920-2022; Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
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NR 19
TC 236
Z9 304
U1 1
U2 33
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2008
VL 122
IS 3
BP 786
EP 797
DI 10.1097/PRS.0b013e31818237ac
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 345KW
UT WOS:000258996700014
PM 18766042
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Johansson, M
   Hlebowicz, J
   Malmsjö, M
   Ingemansson, R
AF Lindstedt, Sandra
   Johansson, Malin
   Hlebowicz, Joanna
   Malmsjo, Malin
   Ingemansson, Richard
TI Myocardial topical negative pressure increases blood flow in
   hypothermic, ischemic myocardium
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE topical negative pressure (TNP); microvascular blood flow; ischemia;
   hypothermia
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND-INFECTION; LASER DOPPLER
   FLOWMETRY; PERISTERNAL THORACIC WALL; LONG-TERM SURVIVAL; POSTSTERNOTOMY
   MEDIASTINITIS; THERAPEUTIC HYPOTHERMIA; CARDIOPULMONARY BYPASS;
   ANGINA-PECTORIS; PORCINE HEART
AB Objectives. Hypothermia protects the myocardium from oxidative injury during ischemic stress and reperfusion. We have previously shown that topical negative pressure (TNP) of -50 mmHg significantly increases microvascular blood flow in the underlying myocardium in normal, ischemic, and reperfused porcine myocardium. The present study was designed to elucidate the effect of TNP between -50 mmHg and -150 mmHg on microvascular blood flow in ischemic myocardium during hypothermia. Design. The microvascular blood flow in the myocardium was recorded, in seven pigs, using laser Doppler velocimetry. Analyses were performed in the epicardium and in the myocardium, after 40 minutes of occlusion of the LAD followed by cooling to 31 degrees C. Results. A TNP of -50 mmHg applied to the epicardium, from 23.3 +/- 3.8 PU to 104.2 +/- 31.3 PU (*p<0.05), and in the myocardium, from 35.0 +/- 7.2 PU to 74.2 +/- 21.8 PU (*p<0.05). Conclusions. Only a TNP level of -50 mmHg significantly increased the microvascular blood flow in both the epicardium and in the myocardium during hypothermia.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Heart & Lung Ctr, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
   [Hlebowicz, Joanna; Malmsjo, Malin] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Heart & Lung Ctr, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473;
   Ingemansson, Richard/0000-0001-7623-8953
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NR 44
TC 3
Z9 3
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2008
VL 42
IS 5
BP 345
EP 353
DI 10.1080/14017430801939225
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 349YE
UT WOS:000259318400009
PM 18609061
OA Bronze
DA 2026-07-24
ER
PT J
AU Koehler, C
   Niederbichler, AD
   Jung, FJ
   Scholz, T
   Labler, L
   Perez, D
   Jandali, A
   Comber, M
   Kuenzi, W
   Wedler, V
AF Koehler, Christian
   Niederbichler, Andreas D.
   Jung, Florian J.
   Scholz, Thomas
   Labler, Ludwig
   Perez, Daniel
   Jandali, Abed
   Comber, Maurice
   Kuenzi, Walter
   Wedler, Volker
TI Wound therapy using the vacuum-assisted closure device: Clinical
   experience with novel indications
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
C1 [Koehler, Christian; Jung, Florian J.; Jandali, Abed; Kuenzi, Walter; Wedler, Volker] Univ Zurich Hosp, Div Plast Hand & Reconstruct Surg, Burn Ctr, CH-8094 Zurich, Switzerland.
   [Scholz, Thomas; Labler, Ludwig; Perez, Daniel; Comber, Maurice] Univ Zurich Hosp, Div Surg, CH-8094 Zurich, Switzerland.
   [Niederbichler, Andreas D.] Hannover Med Sch, Dept Plast Hand & Reconstruct Surg, Burn Ctr, D-3000 Hannover, Germany.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital; Hannover Medical School
RP Koehler, C (通讯作者)，Univ Zurich Hosp, Div Plast Hand & Reconstruct Surg, Burn Ctr, Raemistr 100, CH-8094 Zurich, Switzerland.
EM christian.koehler@usz.ch
OI Perez, Daniel/0000-0002-3154-7311
CR Cohen M, 2001, PLAST RECONSTR SURG, V108, P83, DOI 10.1097/00006534-200107000-00014
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   Emohare O, 2004, J BURN CARE REHABIL, V25, P161, DOI 10.1097/01.BCR.0000111764.67904.CD
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   O'Connor J, 2005, ANN THORAC SURG, V79, P1196, DOI 10.1016/j.athoracsur.2004.09.041
   PLEPP M, 2004, ZENTRALBL CHIR, V129, P24
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
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   Scholl L, 2004, J CARDIAC SURG, V19, P453, DOI 10.1111/j.0886-0440.2004.05002.x
   Schrank C, 2004, ZENTRALBLATT CHIR, V129, P59
   Steiert AE., 2004, ZENTRALBL CHIR, V129, P98, DOI 10.1055/s-2004-822658
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   Tautenhahn J, 2004, ZENTRALBL CHIR, V129, P12
   VOGT PM, 2004, ZENTRALBL CHIR, V129, P92
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   Whelan C, 2005, J UROLOGY, V173, P1463, DOI 10.1097/01.ju.0000157339.05939.21
NR 22
TC 13
Z9 32
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD SEP
PY 2008
VL 65
IS 3
BP 722
EP 731
DI 10.1097/01.ta.0000249295.82527.19
PG 10
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 350BC
UT WOS:000259326400044
PM 18784590
DA 2026-07-24
ER
PT J
AU Randall, KL
   Booth, BA
   Miller, AJ
   Russell, CB
   Laughlin, RT
AF Randall, Kyle L.
   Booth, Branyan A.
   Miller, Adrian J.
   Russell, Corey B.
   Laughlin, Richard T.
TI Use of an acellular regenerative tissue matrix in combination with
   vacuum-assisted closure therapy for treatment of a diabetic foot wound
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE acellular regenerative tissue matrix; chronic wound; diabetes; foot
   ulcer; skin graft; wound vacuum
AB Diabetic foot ulcers can be difficult to treat for a variety of reasons, and may result in amputation. The use of skin grafts can often be a useful method of achieving wound coverage and subsequent healing of diabetic foot ulcers; however, this method of treatment requires creation of a donor site wound that adds to the patient's overall wound burden. Application of an acellular regenerative tissue matrix may eliminate the need for harvesting a skin graft in order to cover a nonhealing wound. The use of vacuum-assisted wound closure has been shown to promote an environment that enhances wound bed contraction and surface epithelialization. The combination of an acellular regenerative tissue matrix with vacuum-assisted wound closure can be used to promote healing in the management of a nonhealing diabetic foot wound.
C1 [Laughlin, Richard T.] Wright State Univ, Boonsholt Sch Med, Dept Orthopaed Surg Sports Med & Rehabil, Dayton, OH 45409 USA.
   [Booth, Branyan A.] Wright State Univ Phys, Dayton, OH USA.
   [Miller, Adrian J.] Miami Valley Hosp Enterostomal Therapy, Continence CNVOCN, Dayton, OH USA.
   [Laughlin, Richard T.] Miami Valley Hosp Foot & Ankle Care Ctr, Dayton, OH USA.
   [Laughlin, Richard T.] Wright State Univ, Dept Orthopaed Sport Med & Rehabil, Dayton, OH 45409 USA.
C3 University System of Ohio; Wright State University Dayton; University
   System of Ohio; Wright State University Dayton; Miami Valley Hospital;
   Miami Valley Hospital; University System of Ohio; Wright State
   University Dayton
RP Laughlin, RT (通讯作者)，Wright State Univ, Boonsholt Sch Med, Dept Orthopaed Surg Sports Med & Rehabil, 30 E Apple St, Suite 2200, Dayton, OH 45409 USA.
EM Richard.laughlin@wright.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brigido SA, 2004, ORTHOPEDICS, V27, pS145
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
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   HARRISON MJG, 1976, J NEUROL SCI, V28, P217, DOI 10.1016/0022-510X(76)90104-0
   Hopf H W, 2001, Foot Ankle Clin, V6, P661, DOI 10.1016/S1083-7515(02)00008-6
   Jude EB, 1999, DIABETOLOGIA, V42, P748, DOI 10.1007/s001250051224
   Kim TN, 1998, J MATER SCI-MATER M, V9, P129, DOI 10.1023/A:1008811501734
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   Veves A, 1998, DIABETES, V47, P457, DOI 10.2337/diabetes.47.3.457
NR 10
TC 14
Z9 30
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD SEP-OCT
PY 2008
VL 47
IS 5
BP 430
EP 433
DI 10.1053/j.jfas.2008.04.012
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 350IV
UT WOS:000259346900009
PM 18725123
DA 2026-07-24
ER
PT J
AU Howell-Taylor, M
   Hall, MG
   Brownlee, WJ
   Taylor, M
AF Howell-Taylor, Melania
   Hall, Macy G., Jr.
   Brownlee, William J., III
   Taylor, Mary
TI Negative pressure wound therapy combined with acoustic pressure wound
   therapy for infected post surgery wounds: A case series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE acoustic pressure wound therapy; wound care; infection; surgery;
   negative pressure wound therapy
ID LOW-FREQUENCY; ULTRASOUND; NONCONTACT; FOOT
AB Acute infection of surgical incision sites often requires specialized wound care in preparation for surgical closure. Optimal therapy for preparing such wounds for a secondary closure procedure remains uncertain. The authors report wound outcomes after administering acoustic pressure wound therapy in conjunction with negative pressure wound therapy with reticulated open-cell foam dressing changes to assist with bacteria removal from open, infected surgical-incision sites in preparation for secondary surgical closure in three patients. Before incorporating acoustic pressure wound therapy at the authors' facility, the average negative pressure wound therapy with reticulated open-cell foam dressing course prior to secondary surgical closure was 30 days; with its addition, two of three patients underwent successful surgical closure with no postoperative complications after 21 and 14 days, respectively; one patient succumbed to nonwound-related complications before wound closure. Larger, prospective studies are needed to evaluate combining negative pressure wound therapy with reticulated open-cell foam dressing and acoustic pressure wound therapy for infected, acute post surgery wounds.
C1 [Howell-Taylor, Melania; Hall, Macy G., Jr.; Brownlee, William J., III; Taylor, Mary] Specialty Hosp Washington Capitol Hill, Washington, DC USA.
RP Howell-Taylor, M (通讯作者)，Specialty Hosp Washington Capitol Hill, Washington, DC USA.
FU Celleration, Inc; Eden Prairie, Minn; HMP Communications/Ostomy Wound
   Management
FX Support for Sound Evidence is provided by an educational grant from
   Celleration, Inc, Eden Prairie, Minn, to HMP Communications/Ostomy Wound
   Management. Celleration support to authors included medical writing
   and/or statistical support only; study design, patient selection, data
   collection, and metrics to measure wound healing are specific to the
   author The opinions and statements herein are also specific to the
   author and are not necessarily those of Celleration, Inc., OWM, or HMP
   Communications. Please note: these articles are subject to peer review.
   The opinions herein may not be consistent with the labeling for MIST
   Therapy Systems. Patients are selected for educational benefit. Visit
   www.celleration.com for the full package insert. Results may vary.
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   *CELL INC, 2006, MIST THER SYST INSTR
   Gehling ML, 2007, OSTOMY WOUND MANAG, V53, P44
   Kavros SJ, 2007, J AM PODIAT MED ASSN, V97, P95, DOI 10.7547/0970095
   Kent Dea J, 2007, Nursing, V37, P36
   Lewis R, 2001, Health Technol Assess, V5, P1
   Liguori PA, 2008, OSTOMY WOUND MANAG, V54, P50
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Stevens DL, 2005, CLIN INFECT DIS, V41, P1373, DOI 10.1086/497143
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
   Unger PG, 2008, OSTOMY WOUND MANAG, V54, P57
   Vermeulen H, 2005, BJS-BRIT J SURG, V92, P665, DOI 10.1002/bjs.5055
NR 13
TC 3
Z9 3
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD SEP
PY 2008
VL 54
IS 9
BP 49
EP 52
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 352CZ
UT WOS:000259474100009
PM 18812625
DA 2026-07-24
ER
PT J
AU Yoong, S
   Dunne, G
   Cochrane, J
   Lee, B
   Lee, J
AF Yoong, Susan
   Dunne, Gillian
   Cochrane, Janette
   Lee, Bernard
   Lee, Jack
TI Vacuum-assisted closure for the treatment of parastomal skin necrosis: A
   novel approach to an unusual complication. Report of a case
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE vacuum-assisted closure; parastomal skin necrosis; parastomal
   complication
AB Extensive peristomal skin necrosis is an unusual complication, which is difficult to manage because of frequent contamination from the stoma site. This wound leads to difficulty in applying the stoma appliance. This case report describes the successful use of the vacuum-assisted closure system in the management of a patient who developed peristomal skin necrosis after emergency Hartmann's procedure.
C1 [Yoong, Susan; Lee, Bernard; Lee, Jack] Belfast City Hosp Trust, Dept Surg, Belfast BT9 7AB, Antrim, North Ireland.
   [Dunne, Gillian; Cochrane, Janette] Belfast City Hosp Trust, Dept Tissue Viabil, Belfast BT9 7AB, Antrim, North Ireland.
C3 Belfast City Hospital; Belfast City Hospital
RP Lee, J (通讯作者)，Belfast City Hosp Trust, Dept Surg, Level 2, Belfast BT9 7AB, Antrim, North Ireland.
EM jack.lee@bch.n-i.nhs.uk
CR Ljung T, 2002, SCAND J GASTROENTERO, V37, P1108, DOI 10.1080/003655202320378338
   Moues C M, 2005, J Wound Care, V14, P224
   Rolstad Bonnie Sue, 2004, Ostomy Wound Manage, V50, P68
   Shellito PC, 1998, DIS COLON RECTUM, V41, P1562, DOI 10.1007/BF02237308
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
NR 5
TC 2
Z9 2
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-3706
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD OCT
PY 2008
VL 51
IS 10
BP 1577
EP 1579
DI 10.1007/s10350-008-9240-5
PG 3
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 352RD
UT WOS:000259514200023
PM 18330646
DA 2026-07-24
ER
PT J
AU Shalom, A
   Eran, H
   Westreich, M
   Friedman, T
AF Shalom, Avshalom
   Eran, Hadad
   Westreich, Melvyn
   Friedman, Tal
TI Our experience with a "homemade" vacuum-assisted closure system
SO ISRAEL MEDICAL ASSOCIATION JOURNAL
LA English
DT Article
DE negative pressure; dressing; cost-effective; improvised
ID SUBATMOSPHERIC PRESSURE; WOUND CONTROL
AB Background: Negative-pressure therapy for the closure of wounds, a technique to accelerate secondary wound healing, is clinically available as the V.A.C.(TM) system (KCI Inc, San Antonio, TX, USA). Budgetary considerations in our institution precluded widespread use of the expensive V.A.C.(TM) system in routine cases.
   Objectives: To develop a less expensive comparably effective dressing, based on the same principles.
   Methods: We used our "homemade" system to treat 15 patients with appropriate complex wounds. Their hospital charts were reviewed and assessed retrospectively. Cost analysis was performed comparing our dressing with the V.A.C.(TM) system.
   Results: Our homemade negative-pressure wound treatment system obtained results similar to what one could expect with the V.A.C.(TM) system in all parameters. Complications encountered were few and minor. Cost per day using our negative-pressure system for a 10 cm(2) wound is about US$1, as compared to US$22, utilizing the V.A.C.(TM) system.
   Conclusions: Our homemade negative-pressure system proved to be a good cost-effective treatment for wound closure in hospitalized patients, yielding results comparable to those of the more expensive V.A.C.(TM) system.
C1 [Friedman, Tal] Assaf Harofeh Med Ctr, Dept Plast Surg, IL-70300 Zerifin, Israel.
   Tel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel.
C3 Shamir Medical Center (Assaf Harofeh); Tel Aviv University; Tel Aviv
   University; Sackler Faculty of Medicine
RP Friedman, T (通讯作者)，Assaf Harofeh Med Ctr, Dept Plast Surg, IL-70300 Zerifin, Israel.
EM fredricag@asaf.health.gov.il
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Chen WM, 2005, GENET EPIDEMIOL, V28, P11, DOI 10.1002/gepi.20034
   DeFranzo AJ, 1999, PLAST RECONSTR SURG, V104, P2145, DOI 10.1097/00006534-199912000-00031
   Fenn CH, 2001, BRIT J PLAST SURG, V54, P348, DOI 10.1054/bjps.2000.3552
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Greer SE, 1999, ANN PLAS SURG, V43, P551, DOI 10.1097/00000637-199911000-00016
   Hallberg H, 2003, SCAND J PLAST RECONS, V37, P97, DOI 10.1080/02844310310005621
   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
NR 15
TC 15
Z9 18
U1 0
U2 2
PU ISRAEL MEDICAL ASSOC JOURNAL
PI RAMAT GAN
PA 2 TWIN TOWERS, 11TH FL, 35 JABOTINSKY ST, PO BOX 3604, RAMAT GAN 52136,
   ISRAEL
SN 1565-1088
J9 ISR MED ASSOC J
JI Isr. Med. Assoc. J.
PD AUG-SEP
PY 2008
VL 10
IS 8-9
BP 613
EP 616
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 352TN
UT WOS:000259520400016
PM 18847164
DA 2026-07-24
ER
PT J
AU Childress, B
   Stechmiller, JK
   Schultz, GS
AF Childress, Beverly
   Stechmiller, Joyce K.
   Schultz, Gregory S.
TI Arginine metabolites in wound fluids from pressure ulcers: A pilot study
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE arginine; nitric oxide; negative pressure; wound therapy; wound healing;
   pressure ulcer
ID NITRIC-OXIDE-SYNTHASE; EXPRESSION; REPAIR; CONTAMINATION; INHIBITION;
   CYTOKINES; PROTEASES; ISOFORMS; ARGINASE; COLLAGEN
AB Compelling evidence suggests that nitric oxide (NO center dot), a metabolite of arginine, plays an important role in wound healing. Arginine is a semi-essential amino acid that is metabolized by nitric oxide synthase and arginase. One model for wound-healing regulation suggests the importance of strict reciprocal control of these enzymes in wounds. The purpose of this pilot study was to investigate arginine metabolism in wound fluids from patients with Stage III or IV pressure ulcers receiving negative pressure wound therapy (NPWT). Wound fluids were collected from 8 patients, aged 31-79 years, before and after initiation of NPWT on Days 1, 3, and 7. Wound fluids were analyzed for nitrates/nitrites (NOx), arginine, citrulline, proline, and ornithine. There were no significant differences between NO,, arginine, citrulline, proline, and ornithine concentrations before and after initiation of NPWT among the various timepoints. However, we observed a downward trend of NO center dot levels from baseline to Day 7 of NPWT treatment. Furthermore, we detected a decrease in arginine levels over the study period, suggesting that the iNOS/citrulline pathway predominated during the first 72 hr of treatment, and the arginase/ornithine pathway dominated thereafter. Arginine and its metabolites are detectable in wound fluids from patients with Stage III or IV pressure ulcers on NPWT. Further studies on chronic wounds are warranted to correlate wound-healing outcomes with arginine metabolites at the cellular and molecular level over a longer period of time.
C1 [Childress, Beverly] VA Off Acad Affiliat, N Florida S Georgia Vet Hlth Syst, Gainesville, FL 32608 USA.
   [Stechmiller, Joyce K.] Univ Florida, Coll Nursing, Adult & Elderly Dept, Gainesville, FL 32611 USA.
   [Schultz, Gregory S.] Univ Florida, Coll Med, Dept Obstet & Gynecol, Gainesville, FL 32611 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Childress, B (通讯作者)，VA Off Acad Affiliat, N Florida S Georgia Vet Hlth Syst, 1601 SW Archer Rd,Vasc 112, Gainesville, FL 32608 USA.
EM Beverly.Childress@va.gov
FU Sigma Theta Tau International; Florida Nurses Foundation; Kinetic
   Concepts, Inc
FX This work was partially supported by grants from the Alpha Theta Tau
   chapter of Sigma Theta Tau International, the Florida Nurses Foundation,
   and Kinetic Concepts, Inc.
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NR 30
TC 9
Z9 12
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2008
VL 10
IS 2
BP 87
EP 92
DI 10.1177/1099800408322215
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nursing
GA 353VI
UT WOS:000259596200002
PM 18829591
DA 2026-07-24
ER
PT J
AU Aust, MC
   Spies, M
   Guggenheim, M
   Gohritz, A
   Kall, S
   Rosenthal, H
   Pichlmaier, M
   Oehlert, G
   Vogt, PM
AF Aust, M. C.
   Spies, M.
   Guggenheim, M.
   Gohritz, A.
   Kall, S.
   Rosenthal, H.
   Pichlmaier, M.
   Oehlert, G.
   Vogt, P. M.
TI Lower limb revascularisation preceding surgical wound coverage - An
   interdisciplinary algorithm for chronic wound closure
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE chronic wounds; arterial occlusive disease; peripheral vascular
   recanalisation; plastic surgical wound closure
ID ANTERIOR THIGH FLAPS; FREE TISSUE TRANSFER; CHRONIC LEG ULCERS;
   LOWER-EXTREMITY; CHRONIC OSTEOMYELITIS; MUSCLE FLAP; PERFORATOR FLAPS;
   FOOT DEFECTS; BLOOD-FLOW; RECONSTRUCTION
AB Background: Chronic wounds may occur or persist due to arterial insufficiency. Despite the high prevalence of arterial occlusive disease, a search of the literature has yielded a paucity of data on the benefit of interventions to recanalise lower extremity arteries prior to surgical closure of chronic wounds.
   Objective: To investigate the correlation of simple clinical examinations and apparative diagnostics for the detection of arterial occlusive disease of the tower extremity in patients with chronic wounds, and to evaluate the benefit of vascular procedures to optimise wound perfusion before surgical closure.
   Patients and methods: During a 6-year period, 150 patients with chronic tower extremity wounds (no heating for more than 30 days) were included into this prospective study. All patients underwent palpation of foot pulses, Doppler sonography and measurement of occlusive pressures. Positive clinical findings were re-evaluated by angiography. All patients with peripheral extremity vessel occlusions underwent vascular interventions (percutaneous transluminal angioplasty with stenting, open thrombectomy or vascular bypass surgery) prior to surgical wound closure.
   Results: In all 34 patients (21%) with missing foot pulses, suspicious Doppler signals or pathological occlusive pressure measurements, the clinical diagnosis of arterial occlusion was confirmed by angiography. An arterial pathology had previously been diagnosed in merely two of those patients. Nineteen patients underwent percutaneous transluminal angioplasty and 21 stents were implanted; in 10 cases, open thrombectomy or vascular bypasses were performed. In all 34 patients, sufficient peripheral recanalisation and improved wound perfusion were successfully achieved.
   For definitive wound closure, microsurgical. tissue transplantation was performed in 15 patients. Angiography was performed prior to surgery. In 11 patients, regional or local flaps were used. Six patients received split skin grafting only; two wounds heated conservatively following vascular intervention. Vacuum-assisted closure (VAC) therapy was applied in 15 cases. Postoperatively, three cases of impaired wound heating and one infection occurred.
   Conclusions: Arterial insufficiency can be diagnosed safety by simple clinical examination. All clinically pathological results were successfully confirmed by angiography, allowing for a targeted peripheral vessel reopening to improve wound perfusion before surgery. This straightforward algorithm helped to improve the success of surgical therapy of chronic lower extremity wounds. (C) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Aust, M. C.; Spies, M.; Gohritz, A.; Kall, S.; Vogt, P. M.] Hannover Med Sch, Clin Plast Hand & Reconstruct Surg, D-30625 Hannover, Germany.
   [Guggenheim, M.] Univ Zurich Hosp, Dept Surg, Div Plast & Reconstruct Surg, Zurich, Switzerland.
   [Rosenthal, H.] Hannover Med Sch, Clin Diagnost Radiol, D-30625 Hannover, Germany.
   [Pichlmaier, M.] Hannover Med Sch, Clin Thorac Heart & Vasc Surg, D-30625 Hannover, Germany.
   [Oehlert, G.] Oststadt Hosp Hannover, Clin Radiol, Hannover, Germany.
C3 Hannover Medical School; University of Zurich; University Zurich
   Hospital; Hannover Medical School; Hannover Medical School
RP Aust, MC (通讯作者)，Hannover Med Sch, Clin Plast Hand & Reconstruct Surg, Carl Neubergstr 1, D-30625 Hannover, Germany.
EM aust_matthias@gmx.de
RI Vogt, Peter/AAL-1332-2020
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NR 47
TC 30
Z9 33
U1 1
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PY 2008
VL 61
IS 8
BP 925
EP 933
DI 10.1016/j.bjps.2007.09.060
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 354EA
UT WOS:000259620500018
PM 18407817
DA 2026-07-24
ER
PT J
AU Bannasch, H
   Iblher, N
   Penna, V
   Torio, N
   Felmerer, G
   Stark, GB
   Momeni, A
AF Bannasch, H.
   Iblher, N.
   Penna, V.
   Torio, N.
   Felmerer, G.
   Stark, G. B.
   Momeni, A.
TI A critical evaluation of the concomitant use of the implantable Doppler
   probe and the vacuum assisted closure system in free tissue transfer
SO MICROSURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   German-Society-for-Plastic-and-Reconstructive-Surgery
CY SEP 06-08, 2007
CL Hannover, GERMANY
SP German Soc Plast & Reconstruct Surg
ID NEGATIVE-PRESSURE DRESSINGS; MICROVASCULAR FREE FLAPS; THICKNESS
   SKIN-GRAFTS; LOWER-EXTREMITY; RECONSTRUCTION
AB Introduction of the Vacuum-Assisted Closure (V.A.C.) system has revolutionized the approach to a multitude of clinical settings. Yet, its use precludes adequate clinical monitoring of skin-grafted free flaps, thus, making a reliable monitoring system essential if broad clinical application is aspired. In a clinical study, the usefulness of the combination of the V.A.C. and implantable Doppler probe was critically evaluated in patients with microsurgical lower extremity reconstruction. We retrospectively analyzed the usefulness of the implantable Doppler probe in five consecutive patients treated in our department from January to July 2007. Inclusion criteria were lower extremity reconstruction by means of skin-grafted free tissue transfers with subsequent application of the V.A.C. device. Five consecutive patients (four males, one female) with a mean age of 37.8 years (range, 8-58 years) matched the criteria mentioned above. Of note, the two pediatric patients (8-year-old male and 12-year-old female) suffered from significant posttraumatic stress disorder necessitating concomitant psychological care by the Department of Psychiatry. All flaps healed uneventfully displaying no signs of vascular compromise. Interpretation of the Doppler signal was simple and well received by the nursing staff. The combination of V.A.C. and the implantable Doppler probe enhances patient comfort due to a reduction of the number of dressing changes while still allowing continuous free flap monitoring. Interpretation of the signal transmitted by the probe is simple and potentially reduces misinterpretations due to different levels of experience. (C) 2008 Wiley-Liss, Inc.
C1 [Bannasch, H.; Iblher, N.; Penna, V.; Torio, N.; Felmerer, G.; Stark, G. B.; Momeni, A.] Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, D-79106 Freiburg, Germany.
C3 University of Freiburg
RP Bannasch, H (通讯作者)，Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Hugstetter Str 55, D-79106 Freiburg, Germany.
EM holger.bannasch@uniklinik-freiburg.de
RI Momeni, Arash/AAV-8300-2020
OI Momeni, Arash/0000-0002-6452-751X
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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NR 20
TC 26
Z9 28
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PY 2008
VL 28
IS 6
BP 412
EP 416
DI 10.1002/micr.20512
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 354FN
UT WOS:000259624400005
PM 18623161
DA 2026-07-24
ER
PT J
AU Horch, RE
   Dragu, A
   Lang, W
   Banwell, P
   Leffler, M
   Grimm, A
   Bach, AD
   Uder, M
   Kneser, U
AF Horch, Raymund E.
   Dragu, Adrian
   Lang, Werner
   Banwell, Paul
   Leffler, Mareike
   Grimm, Andreas
   Bach, Alexander D.
   Uder, Michael
   Kneser, Ulrich
TI Coverage of exposed bones and joints in critically ill patients: Lower
   extremity salvage with topical negative pressure therapy
SO JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TIBIAL SHAFT FRACTURES; POINT-OF-VIEW;
   SUBATMOSPHERIC PRESSURE; RECONSTRUCTIVE SURGERY; TEMPORARY TREATMENT;
   INJURIES; FLAP; WOUNDS; DEFECT
AB Background: Soft tissue defects of the limb with exposure of tendons and bones in critically ill patients usually lead to extremity amputation. A potential treatment with topical negative pressure may allow split-thickness skin grafting to the bone, which leads to limb salvage.
   Materials and Methods: We report on 21 multimorbid patients, 46 to 80 years of age, with severe lower limb soft tissue loss and infection with exposed bone following debridement with critical limb ischemia. Attempts to salvage the extremities were undertaken with repeated surgical debridement followed by vacuum-assisted closure therapy and subsequent split-thickness skin grafting procedures.
   Results: Infection control and limb salvage were achieved in all cases with multiple debridements, topical negative pressure therapy, and skin grafts. In all patients, the exposure of tendons and bones was reversible by this strategy without a free flap transfer.
   Discussion: The patients described in this study were severely compromised by systemic and vascular disorders, so extremity amputation had been considered owing to the overall condition and the exposure of tendons and bones. Since it was possible to salvage the affected limbs with this straightforward and simple procedure, this type of treatment should be considered as a last attempt to prevent amputation.
C1 [Horch, Raymund E.] Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Dept Gen Visceral & Thorac Surg, D-91054 Erlangen, Germany.
   Univ Erlangen Nurnberg, Inst Radiol, D-91054 Erlangen, Germany.
   Nuffield Hosp Brighton, Dept Plast & Reconstruct Surg, E Grinstead, W Sussex, England.
   Queen Victoria Hosp, E Grinstead, W Sussex, England.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Dept Gen Visceral & Thorac Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horck@uk-erlangen.de
RI Horch, Raymund E/H-8128-2019; Dragu, Adrian/AAH-3506-2019
OI Horch, Raymund E/0000-0002-6561-2353; Dragu, Adrian/0000-0003-4633-2695
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   MORYKWAS MJ, 1991, ANN PLAS SURG, V26, P551, DOI 10.1097/00000637-199106000-00009
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Nugent N, 2005, BURNS, V31, P390, DOI 10.1016/j.burns.2004.10.019
   Polykandriotis E, 2006, ZBL CHIR, V131, pS36, DOI 10.1055/s-2006-921476
   Polykandriotis E, 2006, ADV EXP MED BIOL, V585, P311
   Schipper J, 2006, ZBL CHIR, V131, pS141, DOI 10.1055/s-2006-921507
   Schipper J, 2006, HNO, V54, P20, DOI 10.1007/s00106-005-1286-2
   Schipper J, 2007, AURIS NASUS LARYNX, V34, P253, DOI 10.1016/j.anl.2006.07.013
   Seyhan H, 2006, ZBL CHIR, V131, pS33, DOI 10.1055/s-2006-921436
   Strecker T, 2006, J THORAC CARDIOV SUR, V132, P980, DOI 10.1016/j.jtcvs.2006.05.063
   von Gossler C M, 2000, J Cutan Med Surg, V4, P219
   Walgenbach KJ, 2001, VASA-J VASCULAR DIS, V30, P206, DOI 10.1024/0301-1526.30.3.206
   WALGENBACH KJ, 2000, J WOUND HEALING ZFW, V5, P9
   Webb LX, 2004, WOUNDS, P26
NR 46
TC 18
Z9 22
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1203-4754
EI 1615-7109
J9 J CUTAN MED SURG
JI J. Cutan. Med. Surg.
PD SEP-OCT
PY 2008
VL 12
IS 5
BP 223
EP 229
DI 10.2310/7750.2008.07073
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 357NW
UT WOS:000259854400004
PM 18845091
DA 2026-07-24
ER
PT J
AU Olsen, LT
   Fuller, DA
   Milton, J
   Hunt, GJ
AF Olsen, L. Todd
   Fuller, David A.
   Milton, Joseph
   Hunt, G. Jason
TI Subatmospheric Pressure Therapy in the Healing of a Palmar Hand Wound
   With Exposed Median Nerve in a Diabetic Patient
SO ORTHOPEDICS
LA English
DT Article
AB The management of diabetic hand abscesses can be challenging. Wound management after decompression and debridement is complicated by the presence of infection, chronic wound edema, and inhibitory healing factors. An amputation rate of > 60% has been reported.
   This article reports a case of the treatment of a difficult diabetic hand wound with an exposed median nerve. A 56-year-old man presented with a 7-day history of swelling, pain, and erythema in his dominant hand. After serial irrigations and debridement, he had an open wound of the wrist and exposed median nerve. Standard wound vacuum assisted closure (V.A.C.; KCI, San Antonio, Texas) placement was used. After 4 weeks of treatment, the wound had complete granulation, and full epithelial coverage occurred at 10 weeks. Direct application of the wound V.A.C. on an exposed peripheral nerve had not been described.
   It is not clear if the final sensory and motor deficits in the operative hand represent preexisting disease or are the result of the patient's hand infection. Despite the sensory and motor deficits observed during follow-up, the patient was satisfied with his clinical outcome. Application of the V.A.C. system was vital in the elimination of infection and promotion of tissue healing for this historically difficult diabetic hand infection that may have otherwise resulted in a loss of the hand. The V.A.C. system may provide a useful treatment modality in similar difficult wounds with exposed peripheral nerves.
C1 [Olsen, L. Todd] Olsen Orthoped, Midwest City, OK USA.
   [Hunt, G. Jason] St Anthony Hosp, Oklahoma City, OK USA.
   [Fuller, David A.] Univ Med & Dent New Jersey, Cooper Univ Hosp, Newark, NJ 07103 USA.
   [Milton, Joseph] Cooper Univ Hosp, Camden, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Cooper University Hospital
RP Hunt, GJ (通讯作者)，5117 Robin Hill Ln, Oklahoma City, OK 73150 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
J9 ORTHOPEDICS
JI Orthopedics
PD OCT
PY 2008
VL 31
IS 10
BP 1045
EP 1045
PG 1
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 359JW
UT WOS:000259984000025
PM 19225996
DA 2026-07-24
ER
PT J
AU Gudbjartsson, T
   Sigurdsson, HK
   Sigurdsson, E
   Kjartansson, J
AF Gudbjartsson, Tomas
   Sigurdsson, Helgi K.
   Sigurdsson, Engilbert
   Kjartansson, Jens
TI Vacuum-Assisted Closure for Successful Treatment of a Major Contaminated
   Gunshot Chest-Wound: A Case Report
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Chest trauma; Wound healing; Thoracic; Soft tissue injuries and
   infection; Reconstructive surgery; Abdominal trauma; Thoracic and
   abdominal; Multiple trauma
ID FASCIAL CLOSURE; THERAPY; INJURIES
AB Vacuum-assisted closure (VAC) is a well-established treatment for complicated wound infections and chronic wounds, including poststernotomy mediastinitis. The use of VAC in treating high-energy trauma has been more limited. We present a case where VAC was successfully used to treat a contaminated self-inflicted gunshot-wound of the chest and abdomen.
C1 [Gudbjartsson, Tomas] Landspitali Univ Hosp, Dept Cardiothorac Surg, IS-101 Reykjavik, Iceland.
   [Sigurdsson, Helgi K.] Landspitali Univ Hosp, Dept Gen Surg, IS-101 Reykjavik, Iceland.
   [Kjartansson, Jens] Landspitali Univ Hosp, Dept Plast Surg, IS-101 Reykjavik, Iceland.
   [Sigurdsson, Engilbert] Landspitali Univ Hosp, Dept Psychiat, IS-101 Reykjavik, Iceland.
   [Gudbjartsson, Tomas; Sigurdsson, Engilbert; Kjartansson, Jens] Univ Iceland, Fac Med, Reykjavik, Iceland.
C3 Landspitali National University Hospital; Landspitali National
   University Hospital; Landspitali National University Hospital;
   Landspitali National University Hospital; University of Iceland
RP Gudbjartsson, T (通讯作者)，Landspitali Univ Hosp, Dept Cardiothorac Surg, IS-101 Reykjavik, Iceland.
EM tomasgudbjartsson@hotmail.com
RI Sigurdsson, Engilbert/D-2486-2014
OI Sigurdsson, Engilbert/0000-0001-9404-7982
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brown KM, 2001, ANN THORAC SURG, V72, P1409, DOI 10.1016/S0003-4975(01)02844-2
   Herscovici D, 2003, J ORTHOP TRAUMA, V17, P683, DOI 10.1097/00005131-200311000-00004
   Leininger BE, 2006, J TRAUMA, V61, P1207, DOI 10.1097/01.ta.0000241150.15342.da
   Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   McNulty AK, 2007, WOUND REPAIR REGEN, V15, P838, DOI 10.1111/j.1524-475X.2007.00287.x
   O'Connor J, 2005, ANN THORAC SURG, V79, P1196, DOI 10.1016/j.athoracsur.2004.09.041
   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   Roposch A, 1999, J BONE JOINT SURG BR, V81B, P398, DOI 10.1302/0301-620X.81B3.9341
   Stone PA, 2004, J TRAUMA, V57, P1082, DOI 10.1097/01.TA.0000149248.02598.9E
   Suliburk JW, 2003, J TRAUMA, V55, P1155, DOI 10.1097/01.TA.0000100218.03754.6A
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
NR 12
TC 3
Z9 5
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD OCT
PY 2008
VL 34
IS 5
BP 508
EP 510
DI 10.1007/s00068-008-8016-x
PG 3
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 360FH
UT WOS:000260042300012
PM 26815996
DA 2026-07-24
ER
PT J
AU Vikatmaa, P
   Juutilainen, V
   Kuukasjärvi, P
   Malmivaara, A
AF Vikatmaa, P.
   Juutilainen, V.
   Kuukasjarvi, P.
   Malmivaara, A.
TI Negative Pressure Wound Therapy: a Systematic Review on Effectiveness
   and Safety
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE Negative-Pressure Wound Therapy; Wounds; Vacuum-Assisted Closure; Ulcer,
   Review, Systematic
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; MANAGEMENT; ULCERS
AB Objectives: We reviewed the use of negative pressure wound treatment (NPWT) for problematic wounds.
   Methods: A systematic literature review was undertaken to assess the effectiveness and safety of NPWT. Randomized controlled trials (RCTs) assessing NPWT were included.
   Results: A total of 14 RCTs were included. Trials included patients with pressure wounds (2), post-traumatic wounds (3), diabetic foot ulcers (4) and miscellaneous chronic ulcers (5). In all trials NPWT was at least as effective and in some cases more effective than the control treatment. Most evidence supports the effectiveness of NPWT on chronic leg ulcers and posttraumatic ulcers. NPWT appears to be a safe treatment, and serious adverse events have been rarely reported. Only two trials were classified as high quality studies, whereas the remaining were classified as having poor internal validity.
   Conclusions: Reliable evidence on the effectiveness of NPWT is scarce. Tentative evidence indicates that the effectiveness of NPWT is at least as good as or better than current local treatment for wounds. The need for large high-quality randomised studies is apparent. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Vikatmaa, P.] Univ Helsinki, Cent Hosp, Meilahti Hosp, Dept Vasc Surg, Helsinki 00029, Finland.
   [Juutilainen, V.] Univ Helsinki, Cent Hosp, Toolo Hosp, Dept Plast Surg, Helsinki 00029, Finland.
   [Kuukasjarvi, P.; Malmivaara, A.] Finnish Off Hlth Technol Assessment, Stakes, Finland.
C3 University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; Helsinki University Central Hospital; Hyvinkaan Sairaala
RP Vikatmaa, P (通讯作者)，Univ Helsinki, Cent Hosp, Dept Surg, Div Vasc Surg, POB 340, Helsinki 00029, Finland.
EM pirkka.vikatmaa@hus.fi
CR [Anonymous], 2004, COCHRANE DATABASE SY
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   BILBAO JGI, 2005, VACUUM ASSISTED CLOS, P60
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   COSTA V, 2005, NEGATIVE PRESSURE WO, V19, P24
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   MCCALLON S.K., 2000, Ostomy Wound Manage, V46, P28
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   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   *ONT MIN HLTH LONG, 2006, VACC ASS CLOS THER W
   Palfreyman SJ, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001103.pub2
   PEINEMANN F, 2008, BMC MED RESEACH METH, V8
   PHAM C, 2003, 37 ASERNIPS, P53
   Samson D. J., 2004, AHRQ PUBLICATION
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
   UBBINK DT, 2008, COCHRANE DATABASE SY, V2
   VLAYEN J, 2007, KCE REPORTS A, V61
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
NR 33
TC 126
Z9 158
U1 2
U2 29
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD OCT
PY 2008
VL 36
IS 4
BP 438
EP 448
DI 10.1016/j.ejvs.2008.06.010
PG 11
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 363BX
UT WOS:000260242000013
PM 18675559
DA 2026-07-24
ER
PT J
AU Lemaire, V
   Brilmaker, J
   Kerzmann, A
   Jacquemin, D
AF Lemaire, V.
   Brilmaker, J.
   Kerzmann, A.
   Jacquemin, D.
TI Treatment of a Groin Lymphatic Fistula with Negative Pressure Wound
   Therapy
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE Lymphatic diseases; Groin; Negative-pressure wound therapy
AB Introduction: Groin lymphatic fistulas are a troublesome finding after limb revascularization surgery. Its management represents a difficult task for the clinician.
   Report: We report our experience in the treatment of such a condition with negative-pressure wound therapy (NPWT) in a 70-year-old man which benefited from extra-anatomic prosthetic axillofemoral bypass. After a week of treatment, the fistula dried up and closure was obtained with simple suture under local anaesthesia. Follow-up at 9 months showed stable coverage without any sign of leakage.
   Discussion: This study depicts NPWT as an effective non-invasive treatment in the management of groin lymphocutaneous fistula. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Lemaire, V.; Brilmaker, J.; Jacquemin, D.] Univ Liege, Dept Plast & Reconstruct Surg, Liege, Belgium.
   [Kerzmann, A.] Univ Liege, Dept Vasc Surg, Liege, Belgium.
   [Kerzmann, A.] St Nikolaus Hosp, Eupen, Belgium.
C3 University of Liege; University of Liege
RP Lemaire, V (通讯作者)，Domaine Univ Sart Tilman, Univ Hosp Liege, Dept Plast & Reconstruct Surg, Batiment B 35, B-4000 Liege, Belgium.
EM vlemaire@chu.ulg.ac.be
RI /C-7389-2009
OI Kerzmann, Arnaud Louis/0000-0002-9434-3076
CR Abai B, 2007, J VASC SURG, V45, P610, DOI 10.1016/j.jvs.2006.10.043
   Dosluoglu HH, 2005, J VASC SURG, V42, P989, DOI 10.1016/j.jvs.2005.07.006
   Greer SE, 2000, BRIT J PLAST SURG, V53, P484, DOI 10.1054/bjps.2000.3360
   ROBERTS JR, 1993, AM J SURG, V165, P341, DOI 10.1016/S0002-9610(05)80839-6
   Shermak MA, 2005, PLAST RECONSTR SURG, V115, P1954, DOI 10.1097/01.PRS.0000165069.15384.E5
NR 5
TC 17
Z9 21
U1 0
U2 4
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD OCT
PY 2008
VL 36
IS 4
BP 449
EP 451
DI 10.1016/j.ejvs.2008.04.002
PG 3
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 363BX
UT WOS:000260242000014
PM 18524650
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Sumpio, BE
   Allie, DE
   Horvath, KA
   Marston, WA
   Meites, HL
   Mills, JLR
   Orgill, DP
   Salazar, JD
   Song, DH
   Toursarkissian, B
AF Sumpio, Bauer E.
   Allie, David E.
   Horvath, Keith A.
   Marston, William A.
   Meites, Herbert L.
   Mills, Joseph L. R.
   Orgill, Dennis P.
   Salazar, Jorge D.
   Song, David H.
   Toursarkissian, Boulos
TI Role of Negative Pressure Wound Therapy in Treating Peripheral Vascular
   Graft Infections
SO VASCULAR
LA English
DT Article
DE consensus of experts; treatment guidelines; vacuum-assisted therapy;
   vascular graft infections; vascular wounds; wound care
ID VACUUM-ASSISTED CLOSURE; MUSCLE-FLAP COVERAGE; SURGICAL-MANAGEMENT;
   SARTORIUS MYOPLASTY; CLINICAL-EXPERIENCE; GROIN WOUNDS; SURGERY;
   PRESERVATION; BYPASS; DEVICE
AB Wound complications involving large subcutaneous vessels can cause significant challenges for surgeons. Negative pressure wound therapy (NPWT) has been increasingly used for treating complex wounds in vascular surgery, including groin infections, either as a bridge to surgical closure or as a primary wound treatment modality. Although a growing body of evidence exists for managing various problematic wounds, such as diabetic foot ulcers and open abdominal wounds, the role of NPWT in wounds involving large blood vessels or wounds complicating infected vascular grafts has not been well defined. A multidisciplinary advisory panel reviewed the literature relevant to wounds related to vascular surgical procedures and complications, focusing on large subcutaneous or infected vascular conduits. The results supported by the literature and the clinical practice of the consensus panel suggested that NPWT can be a useful adjunct to the management of vascular groin infections and dehiscences but must be used with caution.
C1 [Sumpio, Bauer E.] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06520 USA.
   [Allie, David E.] Lafayette Clin, Cardiovasc Inst S, Dept Surg, Lafayette, LA USA.
   [Horvath, Keith A.] NHLBI, Dept Surg, Bethesda, MD 20892 USA.
   [Horvath, Keith A.] Suburban Hosp, Bethesda, MD USA.
   [Marston, William A.] Univ N Carolina, Dept Surg, Chapel Hill, NC USA.
   [Meites, Herbert L.] Baptist Med Ctr, Dept Surg, Oklahoma City, OK 73112 USA.
   [Mills, Joseph L. R.] Univ Arizona, Hlth Sci Ctr, Dept Surg, Tucson, AZ USA.
   [Orgill, Dennis P.] Harvard Univ, Sch Med, Dept Surg, Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Salazar, Jorge D.; Toursarkissian, Boulos] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
   [Song, David H.] Univ Chicago Hosp, Pritzker Sch Med, Dept Surg, Chicago, IL 60637 USA.
C3 Yale University; National Institutes of Health (NIH) - USA; NIH National
   Heart Lung & Blood Institute (NHLBI); University of North Carolina;
   University of North Carolina Chapel Hill; University of Arizona Health
   Sciences; University of Arizona; Harvard University; Harvard Medical
   School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; University of Texas System; University of Texas at San
   Antonio; University of Illinois System; University of Chicago;
   University of Chicago Medical Center
RP Sumpio, BE (通讯作者)，Yale Univ, Sch Med, Dept Surg, FMB137,POB 208062, New Haven, CT 06520 USA.
EM bauer.sumpio@yale.edu
RI Mills, Joseph/L-2023-2019; Orgill, Dennis/H-7596-2019
OI Mills, Joseph/0000-0002-4955-4384; Orgill, Dennis/0000-0002-8279-7310
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   Andros G, 2006, OSTOMY WOUND MANAG, P1
   [Anonymous], 2004, WOUNDS, p3S
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NR 65
TC 11
Z9 20
U1 2
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD JUL-AUG
PY 2008
VL 16
IS 4
BP 194
EP 200
DI 10.2310/6670.2008.00041
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 365XZ
UT WOS:000260444400003
PM 18845099
DA 2026-07-24
ER
PT J
AU Kumar, S
   O'Donnell, ME
   Khan, K
   Dunne, G
   Carey, PD
   Lee, J
AF Kumar, Susim
   O'Donnell, Mark E.
   Khan, Khalid
   Dunne, Gillian
   Carey, P. Declan
   Lee, Jack
TI Successful treatment of perineal necrotising fasciitis and associated
   pubic bone osteomyelitis with the vacuum assisted closure system
SO WORLD JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
AB Background: Acute necrotising fasciitis is a life-threatening condition, which requires urgent surgical intervention. Surgical debridement is invariably associated with large areas of tissue loss.
   Case presentation: We present a 58-year old woman with a past history of cervical carcinoma who presented with necrotising fasciitis of the perineum and upper thighs with associated pubic bone osteomyelitis. Following extensive debridement, a Vacuum Assisted Closure (VAC) system was applied to the large residual defect to facilitate skin graft application and optimise wound healing.
   Conclusion: This case demonstrates the successful management of a complex and potentially lethal wound of the perineum with debridement, skin grafting and the VAC system.
C1 [Kumar, Susim; O'Donnell, Mark E.; Khan, Khalid; Dunne, Gillian; Carey, P. Declan; Lee, Jack] Belfast City Hosp, Dept Gen Surg, Belfast BT9 7AB, Antrim, North Ireland.
C3 Belfast City Hospital
RP O'Donnell, ME (通讯作者)，Belfast City Hosp, Dept Gen Surg, Lisburn Rd, Belfast BT9 7AB, Antrim, North Ireland.
EM susimkumar@btinternet.com; modonnell904@hotmail.com;
   kalid.khan@belfasttrust.hscni.net; gillian.dunne@belfasttrust.hsci.net;
   declan.carey@belfasttrust.hscni.net; jacklee@doctors.net.uk
CR de Geus HRH, 2005, INTENS CARE MED, V31, P601, DOI 10.1007/s00134-004-2553-5
   Liu SYW, 2006, WORLD J GASTROENTERO, V12, P5256
   Phelps JR, 2006, OSTOMY WOUND MANAG, V52, P54
   Poromanski I, 2004, J Wound Care, V13, P307
   Schaffzin DM, 2004, DIS COLON RECTUM, V47, P1745, DOI 10.1007/s10350-004-0633-9
   Wong CH, 2003, J BONE JOINT SURG AM, V85A, P1454, DOI 10.2106/00004623-200308000-00005
   Young Michael H, 2005, Expert Rev Anti Infect Ther, V3, P279, DOI 10.1586/14787210.3.2.279
   Yuen JC, 2002, J CRANIOFAC SURG, V13, P762, DOI 10.1097/00001665-200211000-00009
NR 8
TC 14
Z9 17
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1477-7819
J9 WORLD J SURG ONCOL
JI World J. Surg. Oncol.
PD JUN 24
PY 2008
VL 6
AR 67
DI 10.1186/1477-7819-6-67
PG 4
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 366JE
UT WOS:000260476200001
PM 18577204
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Richterich, JP
   Heigl, A
   Muff, B
   Luchsinger, S
   Gutzwiller, JP
AF Richterich, Jean-Pierre
   Heigl, Andres
   Muff, Brigitte
   Luchsinger, Sylke
   Gutzwiller, Jean-Pierre
TI Endo-SPONGE-a new endoscopic treatment option in colonoscopy
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; IATROGENIC PERFORATION; ANASTOMOTIC LEAKAGE;
   COLORECTAL-CANCER; WOUND CONTROL; MANAGEMENT; COMPLICATIONS;
   MULTICENTER; GUIDELINES; EXPERIENCE
C1 [Gutzwiller, Jean-Pierre] Spital Zofingen, Gastroenterol Unit, CH-4800 Zofingen, Switzerland.
   [Richterich, Jean-Pierre] Spital Zofingen, Div Surg, CH-4800 Zofingen, Switzerland.
   [Heigl, Andres; Muff, Brigitte] Spital Bulach, Dept Surg, Bulach, Switzerland.
RP Richterich, JP (通讯作者)，Spital Zofingen, Gastroenterol Unit, Muhlethalstr 27, CH-4800 Zofingen, Switzerland.
CR Anderson ML, 2000, AM J GASTROENTEROL, V95, P3418, DOI 10.1111/j.1572-0241.2000.03356.x
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Branagan G, 2005, DIS COLON RECTUM, V48, P1021, DOI 10.1007/s10350-004-0869-4
   CARPIO G, 1989, DIS COLON RECTUM, V32, P624, DOI 10.1007/BF02554186
   Freitag M, 2000, CHIRURG, V71, P568, DOI 10.1007/s001040051104
   Garbay JR, 1996, BRIT J SURG, V83, P42, DOI 10.1002/bjs.1800830112
   Hansen AJ, 2007, J GASTROINTEST SURG, V11, P655, DOI 10.1007/s11605-007-0137-8
   JENTSCHURA D, 1994, SURG ENDOSC-ULTRAS, V8, P672, DOI 10.1007/BF00678564
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Putcha RV, 2003, GASTROENTEROL CLIN N, V32, P1289, DOI 10.1016/S0889-8553(03)00094-3
   Raju GS, 2004, GASTROINTEST ENDOSC, V59, P267, DOI 10.1016/S0016-5107(03)02110-2
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NR 19
TC 5
Z9 7
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD NOV
PY 2008
VL 68
IS 5
BP 1019
EP 1022
DI 10.1016/j.gie.2008.02.038
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 368MC
UT WOS:000260624200048
PM 18534581
DA 2026-07-24
ER
PT J
AU Sentenac, J
AF Sentenac, Jean
TI Facilitating wound healing with VAC therapy: the pharmacist's role
SO EJHP PRACTICE
LA English
DT Article
ID ASSISTED CLOSURE; ULCERS
AB Vacuum Assisted Closure (VAC) therapy is a non-invasive system that facilitates wound healing by applying sub-atmospheric pressure to the wound. Because associated consumables are sterile medical devices, they must be supplied by pharmacists in France, who are valued members of the wound management team.
C1 Ctr Hosp, Pharm Sterilisat Dept, F-11890 Carcassonne 9, France.
RP Sentenac, J (通讯作者)，Ctr Hosp, Pharm Sterilisat Dept, Route St Hilaire, F-11890 Carcassonne 9, France.
EM jean.sentenac@ch-carcassonne.fr
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Baharestani M, 2008, ADV SKIN WOUND CARE, V21, P1
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   LEFRANCE B, 2007, EUR C NANT
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Schuster R, 2006, AM J SURG, V192, P594, DOI 10.1016/j.amjsurg.2006.08.017
   SMITH APS, 2007, CHRONIC WOUND CARE C, P271
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   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 11
TC 0
Z9 0
U1 0
U2 1
PU PHARMA PUBLISHING & MEDIA EUROPE-PPM EUROPE
PI MOL
PA POSTBUS 10001, MOL, B-2400, BELGIUM
SN 1781-9989
EI 2030-3769
J9 EJHP PRACT
JI EJHP Pract.
PY 2008
VL 14
IS 5
BP 57
EP 58
PG 2
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 370GH
UT WOS:000260750200031
DA 2026-07-24
ER
PT J
AU Helgeson, MD
   Potter, BK
   Evans, KN
   Shawen, SB
AF Helgeson, Melvin D.
   Potter, Benjamin K.
   Evans, Korboi N.
   Shawen, Scott B.
TI Bioartificial Dermal Substitute: A Preliminary Report on Its Use for the
   Management of Complex Combat-Related Soft Tissue Wounds
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE blast injury; dermal substitute; Integra; negative pressure dressing;
   split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; ARTIFICIAL SKIN;
   RECONSTRUCTIVE SURGERY; REGENERATION TEMPLATE; CLINICAL-TRIAL; BURN
   INJURY; INTEGRA; EXPERIENCE; DRESSINGS
AB Objective: To report our institutional experience with the use of a bioartificial dermal substitute (Integra) combined with subatmospheric pressure [vacuum-assisted Closure (VAC)] dressings followed by delayed split-thickness skin grafting for management of complex combat-related soft tissue wounds secondary to blast injuries.
   Design: Retrospective review of patients treated December 2004 through November 2005.
   Setting: Military treatment facility.
   Patients/Participants: Integra grafting was performed 18 times in 16 wounds at our institution. Indications for Integra placement were wounds not amenable to simple split-thickness skin grafting. specifically those with substantial exposed bone and/or tendon.
   Intervention: Patients underwent an average of 8.5 irrigation and debridement procedures and concurrent VAC dressings prior to placement of the Integra. Following Integra grafting. all patients were managed with VAC dressings, changed every 3 to 4 days at the bedside or in clinic, with subsequent split-thickness skin grafting an average of 19 days later.
   Main Outcome Measurements: The mechanism and date of injury, size of residual soft tissue deficit, indication for Integra placement, number of irrigation and debridement procedures prior to Integra placement, days from injury to Integra placement, days from Integra placement to split-thickness skin grafting, and clinical outcome were recorded.
   Results: Integra placement and Subsequent skin grafting was successful in achieving durable and cosmetic definitive coverage in 15 of 16 wounds with two of these patients requiring repeat Integra application. Two patients with difficult VAC dressing placement had early Integra graft failure but successfully healed following repeated Integra application and skin grafting.
   Conclusions: Bioartificial dermal substitute grafting, when coupled with subatmospheric dressing management and delayed split-thickness skin grafting, is an effective technique for managing complex combat-related soft tissue wounds with exposed tendon. This can potentially lessen the need for local rotational or free flap coverage.
C1 [Helgeson, Melvin D.; Potter, Benjamin K.; Evans, Korboi N.; Shawen, Scott B.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA.
C3 Walter Reed National Military Medical Center; United States Department
   of Defense; United States Army
RP Shawen, SB (通讯作者)，Walter Reed Army Med Ctr, Orthopaed Surg Serv, 6900 Georgia Ave NW,Bldg 2,Clin 5A, Washington, DC 20307 USA.
EM Scott.Shawen@na.amedd.army.mil
RI Potter,, Benjamin K/U-1769-2019
OI Potter,, Benjamin K/0000-0002-8771-0317
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 35
TC 92
Z9 115
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD JUL
PY 2007
VL 21
IS 6
BP 394
EP 399
DI 10.1097/BOT.0b013e318070c028
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 370SX
UT WOS:000260784500007
PM 17620998
DA 2026-07-24
ER
PT J
AU Pape, HC
   Webb, LX
AF Pape, Hans-Christoph
   Webb, Lawrence X.
TI History of Open Wound and Fracture Treatment
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE open wounds; fracture treatment; VAC; VAC Therapy
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTION
AB This introduction summarizes historical aspects regarding improvements in the treatment of open fractures and complicated wounds. Before the development of standardized surgical wound treatment and antisepsis, amputations were frequently required to prevent sepsis and death. Nowadays, the use of modern scaling techniques has caused a further dramatic reduction in the infection rates and an improvement of the healing response, thus enabling orthopaedic surgeons to perform skin graft coverage, where previously plastic surgeons had to perform skin flaps.
C1 [Pape, Hans-Christoph] Univ Pittsburgh, Med Ctr, Dept Orthopaed Surg, Pittsburgh, PA 15213 USA.
   [Webb, Lawrence X.] Wake Forest Univ, Bowman Gray Sch Med, Dept Orthopaed Surg, Winston Salem, NC USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Wake Forest University; Wake Forest Baptist Medical
   Center
RP Pape, HC (通讯作者)，Univ Pittsburgh, Med Ctr, Dept Orthopaed Surg, Kaufmann Med Bldg,3471 5th Ave,Suite 1010, Pittsburgh, PA 15213 USA.
EM papehc@upmc.edu
OI Pape, Hans-Christoph/0000-0002-2059-4980
CR Aronson J, 1997, J BONE JOINT SURG AM, V79A, P1243, DOI 10.2106/00004623-199708000-00019
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   Li Xue-yong, 2007, Zhonghua Shao Shang Za Zhi, V23, P292
   Morykwas MJ, 1999, J BURN CARE REHABIL, V20, P15, DOI 10.1097/00004630-199901001-00003
   Norbury K, 2007, WOUNDS, V19, P97
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   STEIERT AE, 2008, J PLAST RECONST 0324
   Wangensteen OwenH., 1978, RISE SURG EMPIRIC CR
   Webb Lawrence X, 2006, J Am Acad Orthop Surg, V14, pS82
NR 13
TC 17
Z9 26
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S133
EP S134
DI 10.1097/BOT.0b013e318188e26b
PG 2
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100002
PM 19034158
DA 2026-07-24
ER
PT J
AU Webb, LX
   Pape, HC
AF Webb, Lawrence X.
   Pape, Hans-Christoph
TI Current Thought Regarding the Mechanism of Action of Negative Pressure
   Wound Therapy With Reticulated Open Cell Foam
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE NPWT/ROCF; mechanism of action; VAC; VAC Therapy
ID CLOSURE
AB There arc currently 2 main theories regarding the mechanism of action of negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by VA.C.(R) Therapy (KCI, San Antonio, TX). The first is based on the stimulatory effect of microstrain on cellular mitogenesis, angiogenesis, and elaboration of growth factors. This is the same mechanism that is operational in controlled Ilizarovian distraction or in tissue expansion. The second is based on the enhancement of the dynamics of microcirculation by active evacuation of excess interstitial fluid in the form of edema. Physiologically, there is a lowering of the heightened capillary afterload and a qualitative dilution of contained microcontaminants, bacteria, and proinflammatory cytokines. Based on these effects, the use of NPWT/ROCF has found a place in the management of high-energy traumatic Wounds and certain high-risk elective surgical wounds.
C1 [Webb, Lawrence X.] Wake Forest Univ, Bowman Gray Sch Med, Div Orthopaed Surg, Dept Orthopaed Surg, Winston Salem, NC 27157 USA.
   [Pape, Hans-Christoph] Univ Pittsburgh, Med Ctr, Dept Orthopaed Surg, Pittsburgh, PA USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Webb, LX (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Div Orthopaed Surg, Dept Orthopaed Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM lxwebb@wfubmc.edu
OI Pape, Hans-Christoph/0000-0002-2059-4980
CR Aronson J, 1997, J BONE JOINT SURG AM, V79A, P1243, DOI 10.2106/00004623-199708000-00019
   BRUMBACK RJ, 1989, LOWER EXTREMITY SALV, P71
   Leininger BE, 2006, J TRAUMA, V61, P1207, DOI 10.1097/01.ta.0000241150.15342.da
   Li Xue-yong, 2007, Zhonghua Shao Shang Za Zhi, V23, P292
   MOLNAR JA, 2004, TOPICAL NEGATIVE PRE
   Morykwas MJ, 1999, J BURN CARE REHABIL, V20, P15, DOI 10.1097/00004630-199901001-00003
   Norbury K, 2007, WOUNDS, V19, P97
   REDDIX RN, AM J ORTHOP IN PRESS
   REDDIX RN, 2007, ORTH TRAUM ASS ANN M
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   STANNARD JP, 2007, ORTH TRAUM ASS ANN M
   Webb Lawrence X, 2006, J Am Acad Orthop Surg, V14, pS82
NR 12
TC 28
Z9 34
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S135
EP S137
DI 10.1097/BOT.0b013e31818956ce
PG 3
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100003
PM 19034159
DA 2026-07-24
ER
PT J
AU Powell, ET
AF Powell, Ehaa T.
TI The Role of Negative Pressure Wound Therapy With Reticulated Open Cell
   Foam in the Treatment of War Wounds
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE NPWT/ROCF; aeromedical; VAC; VAC Therapy
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; EXPERIENCE
AB The treatment of war wounds poses many unique challenges to all healthcare providers (surgeons, flight medics, nurses, etc.), whether they arc located at the far forward trauma hospitals located in or near areas of conflict, at regional hospitals Such as Landstuhl Medical Center in Germany, or the larger military hospitals in the United States. These complex wounds often involve massive loss of soft tissue and bone, arc contaminated, and are unlike most injuries seen at civilian hospitals. Treatment guidelines, or doctrine, Lire the result of lessons learned in conflicts over the past few centuries dating back to early 19th century Europe through the Vietnam and recent Persian Gulf war. Advances in surgical and medical treatment have resulted from the complex challenges presented to the war trauma surgeon. More than I million patients have been treated for chronic pressure ulcers, abdominal wounds, diabetic ulcers. and acute civilian trauma wounds with negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by VA.C.(R) Therapy (KCI, San Antonio. TX) for over the past decade. However, the use of NPWT/ROCF for the care of war Wounds at battlefield trauma hospitals and/or in the aeromedical evacuation transport system aboard aircraft is a new application of this wound treatment not yet accepted as doctrine. Investigational studies are ongoing to Study the safety and efficacy of the treatment of battlefield wounds with NPWT/ROCF both for those national citizens treated at the trauma hospitals in Iraq and Afghanistan and for those Wounded American and coalition patients who are transported through the aeromedical transport system to medical centers in the United States.
C1 [Powell, Ehaa T.] 3rd Med Grp, Elmendorf AFB, AK USA.
C3 United States Department of Defense; United States Air Force
RP Powell, ET (通讯作者)，Alaska Reg Hosp, 2751 DeBarr Rd,Suite 310, Anchorage, AK 99508 USA.
EM etpowell@gci.net
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bagg Mark R, 2006, J Am Acad Orthop Surg, V14, pS7
   BURRIS DG, 2004, EMERGENCY WAR SURG 3
   Covey Dana C, 2008, Instr Course Lect, V57, P65
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   Ingari John V, 2007, Tech Hand Up Extrem Surg, V11, P130, DOI 10.1097/bth.0b013e3180312738
   Joseph E, 2000, WOUNDS, V12, P60
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   *US DEP DEF, DEF LINK US CAS STAT
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
NR 15
TC 28
Z9 36
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S138
EP S141
DI 10.1097/BOT.0b013e318188e27d
PG 4
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100004
PM 19034160
DA 2026-07-24
ER
PT J
AU Pollak, AN
AF Pollak, Andrew N.
TI Use of Negative Pressure Wound Therapy With Reticulated Open Cell Foam
   for Lower Extremity Trauma
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE NPWT/ROCF; VAC; VAC Therapy
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; TIBIAL SHAFT FRACTURES;
   TEMPORARY TREATMENT; MANAGEMENT; RECONSTRUCTION; DEFECTS
AB The use of negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by VA.C.(R) Therapy (KCI, San Antonio, TX) has been a valuable adjunct in the treatment of complex lower-extremity injuries. The use of NPWT/ROCF for lower extremity traumatic wounds is based oil mechanical effects on the surrounding tissues, biological effects at the cellular level, and simplification of wound care for nursing personnel. For patients with compartment syndrome, risk of secondary infection and need for skin grafting to achieve soft-tissue coverage may theoretically be reduced. For traumatic wounds, dressing care may be simplified and healing encouraged. For surgical incisions, risk of secondary wound dehiscence and infection may be lowered.
C1 Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Div Orthopaed Traumatol, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP Pollak, AN (通讯作者)，Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Div Orthopaed Traumatol, S Greene St,Suite T3R54, Baltimore, MD 21201 USA.
EM apollak@runoa.unuu.edu
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   Dedmond BT, 2007, J ORTHOP TRAUMA, V21, P11, DOI 10.1097/BOT.0b013e31802cbc54
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
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   LALLISS SJ, 2007, ANN M ORTH TRAUM ASS
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Pollak AN, 2000, J BONE JOINT SURG AM, V82A, P1681, DOI 10.2106/00004623-200012000-00001
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   STANNARD JP, 2007, ANN M ORTH TRAUM ASS
   STANNARD JP, 2008, 75 ANN M AM AC ORTH
   Tarkin IS, 2008, INJURY, V39, P142, DOI 10.1016/j.injury.2007.07.024
NR 20
TC 30
Z9 33
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S142
EP S145
DI 10.1097/BOT.0b013e318188e2a9
PG 4
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100005
PM 19034161
DA 2026-07-24
ER
PT J
AU Tarkin, IS
AF Tarkin, Ivan S.
TI The Versatility of Negative Pressure Wound Therapy with Reticulated Open
   Cell Foam for Soft Tissue Management After Severe Musculoskeletal Trauma
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE NPWT/ROCF; VAC; VAC Therapy
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE;
   OPEN FRACTURES; LOWER-LIMBS; BOLSTER
AB This review serves to outline the current and evolving usages of negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by VA.C.(R) Therapy (KCI, San Antonio. TX) as an adjunctive treatment modality for optimal management of wounds associated with high energy musculoskeletal trauma.
C1 Univ Pittsburgh, Dept Orthopaed Surg, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Tarkin, IS (通讯作者)，Univ Pittsburgh, Dept Orthopaed Surg, Kaufmann Med Bldg,3471 5th Ave, Pittsburgh, PA 15213 USA.
EM tarkinis@upmc.edu
CR AMBROSIO A, 2005, VAC GRANUFOAM SILVER
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   Dedmond BT, 2007, J ORTHOP TRAUMA, V21, P11, DOI 10.1097/BOT.0b013e31802cbc54
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NR 42
TC 12
Z9 12
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S146
EP S151
DI 10.1097/BOT.0b013e318188e2bc
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100006
PM 19034162
DA 2026-07-24
ER
PT J
AU Schlatterer, D
   Hirshorn, K
AF Schlatterer, Daniel
   Hirshorn, Kurt
TI Negative Pressure Wound Therapy With Reticulated Open Cell
   Foam-Adjunctive Treatment in the Management of Traumatic Wounds of the
   Leg: A Review of the Literature
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Review
DE NPWT/ROCF; infection; skin graft; dermal grafts; muscle flap; VAC; VAC
   Therapy
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; SECURING SKIN-GRAFTS;
   TIBIAL SHAFT FRACTURES; FLAP DONOR-SITE; IN-VITRO MODEL; SUBATMOSPHERIC
   PRESSURE; CHRONIC OSTEOMYELITIS; VAC(TM) INSTILLATION;
   CLINICAL-EXPERIENCE
AB Over the last decade, the application of and indications for negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by VA.C.(R) Therapy (KCI, San Antonio, TX) have grown tremendously. This is particularly true in orthopaedic trauma in the management of injuries to the leg, ankle, and foot. This article reviews the evidence-based medicine in terms of NPWT/ROCF, as a method of reducing bacterial counts in wounds, as a bridge until definitive bony coverage, for treating infections, and as ail adjunct to Wound bed preparation and for bolstering split-thickness skin grafts, dermal replacement grafts, and over muscle flaps. NPWT/ROCF has been shown to be ail adjunct to the mainstays of wound management. No significant complications have been noted in the categories of NPWT/ROCF discussed in this reviews In addition, evidence Supports a decrease in complex soft tissue procedures in grade IIIB open fractures when NPWT/ROCF is employed. Although more research needs to be done, NPWT/ROCF appears to provide clinical benefit for the treatment of these complex lower extremity wounds.
C1 [Schlatterer, Daniel; Hirshorn, Kurt] Atlanta Med Ctr, Dept Orthoped Surg, Atlanta, GA 30312 USA.
C3 WellStar Atlanta Medical Center
RP Schlatterer, D (通讯作者)，Atlanta Med Ctr, Dept Orthoped Surg, 303 Pkwy Dr NE, Atlanta, GA 30312 USA.
EM daniel.schlatterer@tenethealth.com
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NR 43
TC 23
Z9 29
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S152
EP S160
DI 10.1097/BOT.0b013e318188e2d7
PG 9
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100007
PM 19034163
DA 2026-07-24
ER
PT J
AU Levin, LS
AF Levin, L. Scott
TI Principles of Definitive Soft Tissue Coverage With Flaps
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE NWPT/ROCF; flaps; VAC; VAC Therapy
ID SURAL ISLAND FLAP; OPEN TIBIAL FRACTURE; CROSS-LEG FLAP; FASCIOCUTANEOUS
   FLAP; RECONSTRUCTION; ANKLE; FOOT; DEFECTS; MICROSURGERY; MANAGEMENT
AB Despite the emergence of negative pressure Wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by VA.C.(R) Therapy (KCI, San Antonio, TX) for orthopaedic trauma, vascularized tissue transfer whether it be pedicle, free, or tissue transfer using the operating microscope or as an island, remains the mainstay of soft tissue reconstruction for orthopaedic traumatology. The critisism of microvascular procedures has been that they are lengthy, costly, and required technical expertise to perform. While technical skills are required, microsurgical care has evolved into a routine operation with high degrees of success in experienced hand. The problem that still remains is access to surgeons who are interested in Soft tissue reconstruction and can perform definitive coverage with flaps. There is a need in the orthopaedic community to solve the problem of lack of flap surgeons and as a result, NPWT/ROCF has been touted as the answer to flap reconstruction. NPWT/ROCF is an important addition to soft tissue reconstruction but it serves as a bridge rather than definitive coverage in many hands. Just as wound technology is evolving with tissue substitutes, growth factors and NPWT/ROCF flaps technology continues to advance with new perforator flaps and local regional flaps, particularly the sural flap, coming on line as mainstays of soft tissue reconstruction
C1 [Levin, L. Scott] Duke Univ, Med Ctr, Div Orthopaed Surg, Durham, NC 27710 USA.
   [Levin, L. Scott] Duke Univ, Med Ctr, Div Plast & Reconstruct Surg, Durham, NC 27710 USA.
C3 Duke University; Duke University
RP Levin, LS (通讯作者)，Duke Univ, Med Ctr, Div Orthopaed Surg, Box 3945, Durham, NC 27710 USA.
EM levin001@mc.duke.edu
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NR 36
TC 20
Z9 23
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S161
EP S166
DI 10.1097/BOT.0b013e318188e2ed
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100008
PM 19034164
DA 2026-07-24
ER
PT J
AU Contractor, D
   Amling, J
   Brandoi, C
   Tosi, LL
AF Contractor, Dhruti
   Amling, June
   Brandoi, Cinzia
   Tosi, Laura L.
TI Negative Pressure Wound Therapy With Reticulated Open Cell Foam in
   Children: An Overview
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE NPWT/ROCF; children; pediatric; wound; infection; VAC; VAC Therapy
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUNDS; SUBATMOSPHERIC PRESSURE;
   MANAGEMENT; MEDIASTINITIS; FRACTURES; INFECTION; INJURIES; TRIAL
AB This article summarizes the results of a comprehensive review of the literature on the use of negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by VA.C.(R) Therapy (KCI, San Antonio, TX) in pediatric patients. A review of the literature revealed 20 articles that discussed the use of NPWT/ROCF in exclusively pediatric patients. Nine articles were retrospective reviews, and I I Were Case Studies. This review discusses the insights from these articles. This review discusses the versatility of NPWT/ROCF for use with pediatric patients with infected wounds; full-thickness burns; open fractures large soft tissue wounds; surgical wounds of the chest, abdomen, and spine; pilonidal disease; and pressure ulcers. NPWT/ROCF has been used in children as young as a few weeks of age, and in children with comorbidities such as congenital heart disease, immunosuppression, And spina bifida. Wound heating in children can be delayed by impaired perfusion, infection, edema, and poor nutrition. Clinical considerations for using NPWT/ROCF in children can include differences in healing due to higher granulation rates requiring more frequent dressing changes, poor nutritional status, small size, and low weight. With pediatric patients, there is no consensus on foam (white or black) selection, optimum amount of negative pressure, frequency of NPWT/ROCF dressing changes, and interposing contact layer selection. Randomized prospective Studies are needed to make recommendations for safe and efficacious clinical practice. Research regarding the effects of dressing types, adjunctive treatment, and wound healing in neonates and children is needed.
C1 [Tosi, Laura L.] Childrens Natl Med Ctr, Bone Hlth Program, Washington, DC 20010 USA.
   [Contractor, Dhruti; Tosi, Laura L.] George Washington Univ, Sch Med, Washington, DC USA.
C3 Children's National Health System; George Washington University
RP Tosi, LL (通讯作者)，Childrens Natl Med Ctr, Bone Hlth Program, 111 Michigan Ave,NW, Washington, DC 20010 USA.
EM ltosi@crunc.org
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NR 46
TC 27
Z9 36
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S167
EP S176
DI 10.1097/BOT.0b013e318188e295
PG 10
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100009
PM 19034165
DA 2026-07-24
ER
PT J
AU Poulakidas, S
   Cologne, K
   Kowa-Vern, A
AF Poulakidas, Stathis
   Cologne, Kyle
   Kowa-Vern, Areta
TI Treatment of Frostbite With Subatmospheric Pressure Therapy
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EXTREMITIES; AMPUTATION; STATE
AB Frostbite may result in loss of skin and tissue requiring amputation; it occurs most often on the exposed areas such as extremity, digits, ears, etc. The usual treatment is observation for demarcation of the injury before amputation or autoamputation of the dry gangrene that may set in between 1 and 3 weeks. In some instances, tissue viability is assessed by a pyrophosphate nuclear scan. This was a 43-year-old African-American man who developed frost-bite of his right foot. He presented 72 hours after injury with hyperemia and cellulitis over the dorsum of the foot and a blistered dorsal surface of the great toe with loss of sensation on all toes and early signs of necrosis. The patient received a 7-day course of ampicillin-sulbactam and a 6-day course of vacuum-assisted closure therapy during a 7-day hospitalization. At the time of discharge, lie had re-epithialialization of the dorsal surface of the right toe and healthy granulation tissue with islands of epidermis emerging on the ventral surface of the right toe. Re-epithelialization was complete by 26 days after injury. In the future, this treatment therapy may find a larger application in frostbite injuries because it may accelerate healing. A study of frostbite treatment confirming the usefulness of this modality may be indicated. (J Burn Care Res 2008;29:1012-1014)
C1 [Poulakidas, Stathis; Cologne, Kyle; Kowa-Vern, Areta] John H Stroger Jr Hosp Cook Cty, Dept Trauma, Sumner L Koch Burn Ctr, Chicago, IL USA.
C3 John H Stroger Junior Hospital Cook County; University of Illinois
   System; University of Illinois Chicago; University of Illinois Chicago
   Hospital
RP Poulakidas, S (通讯作者)，Sumner L Koch Burn Ctr, Room 3229,1901 W Harrison St, Chicago, IL 60612 USA.
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NR 25
TC 11
Z9 11
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD NOV-DEC
PY 2008
VL 29
IS 6
BP 1012
EP 1014
DI 10.1097/BCR.0b013e31818ba0ad
PG 3
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 372ZD
UT WOS:000260939900028
PM 18849842
DA 2026-07-24
ER
PT J
AU Wondberg, D
   Larusson, HJ
   Metzger, U
   Platz, A
   Zingg, U
AF Wondberg, D.
   Larusson, H. J.
   Metzger, U.
   Platz, A.
   Zingg, U.
TI Treatment of the Open Abdomen with the Commercially Available
   Vacuum-Assisted Closure System in Patients with Abdominal Sepsis
SO WORLD JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT International Surgical Week Conference
CY AUG 26-30, 2007
CL Montreal, CANADA
ID FASCIAL CLOSURE; WOUND CLOSURE; VENTRAL HERNIA; PACK TECHNIQUE;
   EXPERIENCE; DEVICE
AB Abdominal Vacuum-Assisted Closure (V.A.C.) systems for treatment of open abdomens have been predominantly used for trauma patients with a high primary fascial closure rate. Use of the V.A.C. technique in abdominal sepsis is less well established.
   All patients with abdominal sepsis and treatment with the abdominal V.A.C. system between 2004 and 2007 were prospectively assessed. End points were fascial closure, V.A.C.-related morbidity, and quality of life score (SF-36) at follow-up.
   Thirty patients with abdominal sepsis were included in the study. Primary fascial closure was feasible in 10, partial closure in 4, and no closure in 16 patients. Median number of V.A.C. changes was 3 (range, 1-10). Nine patients died. V.A.C.-related morbidity was as follows: two fistulas, three fascial edge necroses, one skin blister, and four prolapses of small bowel between the fascia and foam. Univariate analysis showed no variables influencing primary closure rate or V.A.C.-related morbidity. Mortality was significantly influenced by age (P < 0.001), respiratory failure (P = 0.01), and pneumonia (P = 0.03). At follow-up, V.A.C. patients scored lower in the physical health scores and similar in the mental health scores compared with the normal population.
   Treatment of the open abdomen in patients with abdominal sepsis with the abdominal V.A.C. system is safe with good long-term quality of life. Primary closure rate in these patients is substantially lower than in trauma patients. Stepwise closure of the fascia during V.A.C. changes should be attempted to avoid additional lateral retraction of fascial edges. V.A.C.-related complications may be avoided with careful surgical technique.
C1 [Larusson, H. J.; Zingg, U.] Univ Basel Hosp, Dept Surg, CH-4031 Basel, Switzerland.
   [Wondberg, D.; Metzger, U.; Platz, A.; Zingg, U.] Triemli Hosp Zurich, Dept Surg, CH-8063 Zurich, Switzerland.
C3 University of Basel; Triemli Hospital
RP Zingg, U (通讯作者)，Univ Basel Hosp, Dept Surg, Spitalstr 21, CH-4031 Basel, Switzerland.
EM uzingg@uhbs.ch
OI Zingg, Urs/0000-0001-9751-4064
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NR 28
TC 74
Z9 85
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD DEC
PY 2008
VL 32
IS 12
BP 2724
EP 2729
DI 10.1007/s00268-008-9762-y
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 373JS
UT WOS:000260968500032
PM 18836762
DA 2026-07-24
ER
PT J
AU Baharestani, MM
   Houliston-Otto, DB
   Barnes, S
AF Baharestani, Mona M.
   Houliston-Otto, Deborah B.
   Barnes, Sunni
TI Early Versus Late Initiation of Negative Pressure Wound Therapy:
   Examining the Impact on Home Care Length of Stay
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE negative pressure wound therapy; pressure ulcer; home care; surgical
   wound
AB Because of the high cost of some wound management regimens, payors may require that moist wound therapies be used before other treatment approaches, such as negative pressure wound therapy (NPWT), are implemented but few studies have investigated the effect of delayed initiation of NPWT on patient outcomes. To examine the impact of early versus late initiation of NPWT on patient length of stay in home health care, a nonrandomized, retrospective analysis was performed on the Outcome and Assessment Information Set (OASIS) information for home care patients with NPWT-treated Stage III or Stage IV pressure ulcers (N = 98) or surgical wounds (N = 464) gathered between July 2002 and September 2004. Early initiation of NPWT following the start of home care was defined as < 30 days for pressure ulcers and < 7 days for surgical wound patients. Median duration of NPWT was 31 days (range 3 to 169) for pressure ulcers and 27 days (range 5 to 119) for the surgical wound group. Median lengths of stay in the early treatment groups were 85 days (range 11 to 239) for pressure ulcers and 57 days (range 7 to 119) for the surgical group versus 166 days (range 60 to 657) and 87 days (range 31 to 328), respectively, for the late treatment pressure ulcer and surgical groups (P < 0.0001). After controlling demographic patient variables, regression analysis indicated that for each day NPWT initiation was delayed, almost 1 day was added to the total length of stay (beta = 0.96, P < 0.0001 [pressure ulcers]; P = 0.97, P < 0.0001 [surgical wounds]). Early initiation of NPWT may be associated with shorter length of stay for patients receiving home care for Stage III or Stage IV pressure ulcers or surgical wounds. Additional studies to ascertain the cost-effectiveness of treatments and treatment approaches in home care patients are needed.
C1 [Baharestani, Mona M.] E Tennessee State Univ, Ctr Nursing Res, Off 1 112, Johnson City, TN 37614 USA.
   [Baharestani, Mona M.] James H Quillen Vet Affairs Med Ctr, Johnson City, TN USA.
C3 East Tennessee State University
RP Baharestani, MM (通讯作者)，E Tennessee State Univ, Ctr Nursing Res, Off 1 112, Roy Nicks Hall, Johnson City, TN 37614 USA.
EM Baharest@etsu.edu
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   Kobza L, 2000, Ostomy Wound Manage, V46, P48
   Schaum Kathleen D, 2002, Home Healthc Nurse, V20, P57, DOI 10.1097/00004045-200201000-00014
   Schwien T, 2005, OSTOMY WOUND MANAG, V51, P47
NR 13
TC 19
Z9 19
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD NOV
PY 2008
VL 54
IS 11
BP 48
EP 53
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 381CF
UT WOS:000261511800009
PM 19037137
DA 2026-07-24
ER
PT J
AU Brandi, C
   Grimaldi, L
   Nisi, G
   Silvestri, A
   Brafa, A
   Calabrò, M
   D'Aniello, C
AF Brandi, C.
   Grimaldi, L.
   Nisi, G.
   Silvestri, A.
   Brafa, A.
   Calabro, M.
   D'Aniello, C.
TI Treatment with vacuum-assisted closure and cryo-preserved homologous
   de-epidermalised dermis of complex traumas to the lower limbs with loss
   of substance, and bones and tendons exposure
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE VAC therapy; Lower limbs injuries; DED; Traumatic wound
ID WOUND CONTROL; THERAPY; KERATINOCYTES; FIBROBLASTS; MANAGEMENT; CULTURE
AB Lower-limb injuries with toss of tissue and exposure of bones and tendons are an increasing problem. The condition of the wound locally and the patient in general does not always allow immediate and adequate coverage of the structures exposed by the trauma. Therefore, new therapeutic solutions are needed. A reduction in the time that bones and tendons are exposed is essential to achieve complete heating of bone fractures, with reduced risks of infection and less disabling outcomes.
   The effectiveness of vacuum-assisted closure (VAC) therapy in supporting wound heating and of cryopreserved homologous de-epidermalised dermis (DED) in providing an effective template for re-epithelialisation has been previously reported. We carried out a study to evaluate the effectiveness of the synergistic and combined use of the two methodologies. Eighteen patients with traumatic loss of tissue in the lower limbs, involving exposure of bone and tendon structures, were enrolled in the study. All participants had local, general contraindications to first-instance reconstructions, or both.
   All patients received a combination of VAC therapy and DED implants. Granulation tissue was obtained in all wounds, with complete coverage of exposed structures. No infections were detected in the cohort, and all patients were prepared for further necessary reconstructive treatments. In our experience, the combination of VAC therapy and DED could, in selected cases, constitute an effective treatment for complex lower limb traumatic injuries with bone and tendon exposure. (C) 2007 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Brandi, C.; Grimaldi, L.; Nisi, G.; Silvestri, A.; Brafa, A.; Calabro, M.; D'Aniello, C.] Univ Siena, Policlin S Maria Scotte, Dept Gen & Specialist Surg, Plast Surg Unit, I-53100 Siena, Italy.
C3 University of Siena
RP Brandi, C (通讯作者)，Univ Siena, Policlin S Maria Scotte, Dept Gen & Specialist Surg, Plast Surg Unit, Viale Bracci, I-53100 Siena, Italy.
EM cesarebrandi@virgilio.it
OI D'ANIELLO, CARLO/0000-0002-1561-9936; Nisi,
   Giuseppe/0000-0002-0357-8487; Grimaldi, Luca/0000-0002-9251-4396;
   BRANDI, CESARE/0000-0001-9755-7953
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brandi Cesare, 2004, Chir Ital, V56, P425
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
   Court-Brown CM, 1997, BRIT J PLAST SURG, V50, P570, DOI 10.1016/S0007-1226(97)90501-4
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   Haddow DB, 2003, J BIOMED MATER RES A, V64A, P80, DOI 10.1002/jbm.a.10356
   Josty IC, 2001, BRIT J PLAST SURG, V54, P363, DOI 10.1054/bjps.2000.3565
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
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   NAVSARIA HA, 1993, BR J PLAST SURG, V46, P460
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Sposato G, 2001, BRIT J PLAST SURG, V54, P235, DOI 10.1054/bjps.2000.3537
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
NR 20
TC 10
Z9 23
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2008
VL 61
IS 12
BP 1507
EP 1511
DI 10.1016/j.bjps.2007.09.036
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 381EI
UT WOS:000261518000015
PM 17993300
DA 2026-07-24
ER
PT J
AU Descheemaeker, V
   Aillet, S
   Morcel, K
   Gravier, A
   Meyer, N
   Leveque, J
AF Descheemaeker, V.
   Aillet, S.
   Morcel, K.
   Gravier, A.
   Meyer, N.
   Leveque, J.
TI Pyoderma gangrenosum and breast cancer: A case report
SO JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION
LA French
DT Article
DE Breast cancer; Pyoderma gangrenosum; Surgery
ID GANGRAENOSUM
AB The authors report a case of pyoderma gangrenosum (PG) following a breast lumpectomy for a relapse of a breast cancer. The treatment has associated a systemic corticosteroid therapy and local wound care with vacuum assisted closure Vacuum-Assisted Closure (R) and skin graft. (C) 2008 Elsevier Masson SAS. Tous droits reserves.
C1 [Descheemaeker, V.; Aillet, S.; Morcel, K.; Leveque, J.] CHU Anne de Bretagne, Dept Obstet Gynecol & Med Reprod, Unite Chirurg Plast & Reconstruct, F-35203 Rennes 2, France.
   [Descheemaeker, V.; Leveque, J.] Ctr Reg Lutte Canc Eugene Marquis, Dept Chirurg, Rennes, France.
   [Gravier, A.] Ctr Hosp Y Le Foll, Serv Gynecol Obstet, St Brieuc, France.
   [Meyer, N.] CHU Pontchaillou, Serv Dermatol, Rennes, France.
C3 CHU Rennes; UNICANCER; Centre Eugene Marquis; Universite de Rennes; CHU
   Rennes; Universite de Rennes
RP Leveque, J (通讯作者)，CHU Anne de Bretagne, Dept Obstet Gynecol & Med Reprod, Unite Chirurg Plast & Reconstruct, 16 Blvd Bulgarie,BP 90347, F-35203 Rennes 2, France.
EM jean.leveque@chu-rennes.fr
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NR 31
TC 12
Z9 12
U1 0
U2 1
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 0368-2315
EI 1773-0430
J9 J GYNECOL OBST BIO R
JI J. Gynecol. Obstet. Biol. Reprod.
PD OCT
PY 2008
VL 37
IS 6
BP 618
EP 621
DI 10.1016/j.jgyn.2008.06.001
PG 4
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 381ZT
UT WOS:000261575100013
PM 18640792
DA 2026-07-24
ER
PT J
AU Baharestani, M
   Driver, VR
AF Baharestani, Mona
   Driver, Vickie R.
TI Optimizing Clinical and Cost Effectiveness with Early Intervention of
   VAC® Therapy
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE Vacuum Assisted Closure; negative pressure wound therapy; VAC Therapy;
   VAC; cost effectiveness; wound therapy; NPWT
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; SOFT-TISSUE INJURIES;
   DIABETIC FOOT ULCERS; SECURING SKIN-GRAFTS; RANDOMIZED-TRIAL; STERNAL
   WOUNDS; MANAGEMENT; INFECTIONS; DRESSINGS
AB Negative pressure wound therapy (ie, Vacuum Assisted Closure) is used in conjunction with surgical techniques and other modalities to manage acute and chronic wounds. The management of these wounds includes a comprehensive patient assessment and takes into account effective treatment options and cost-effective care. Although Vacuum Assisted Closure is a proven advanced therapy system for the treatment of acute wounds (ie, surgical, traumatic) and chronic wounds (eg, pressure ulcers and diabetic foot wounds), there is a dearth of evidence addressing clinical and cost effectiveness associated with early intervention involving negative pressure wound therapy utilizing reticulated, open cell foam (NPWT/ROCF) in the wound healing process. A panel of experts was convened to determine specific goals and signals for early intervention with NPWT/ROCF, as well as cost implications. Using the literature and their expertise, they established: 1) implementation of NPWT/ROCF early in the healing process of acute wounds is indicated where immediate closure is not an option and/or the wound bed requires preparation for future closure; 2) implementation of NPWT/ROCF is a viable option for chronic wounds such as pressure ulcers and diabetic foot wounds that are not progressing to healing after 4 weeks of treatment; and 3) early implementation of NPWT/ROCF can offset costs incurred by lengthy therapy and sequelae. This paper is intended to help clinicians understand the rationale for early application of NPWT/ROCF and to establish treatment protocols for early intervention.
C1 [Baharestani, Mona] E Tennessee State Univ, Ctr Nursing Res, Johnson City, TN 37614 USA.
   [Baharestani, Mona] James H Quillen Vet Affairs, Johnson City, TN USA.
   [Driver, Vickie R.] Boston Med Univ, Dept Surg, Boston Med Ctr, Endovasc & Vasc Serv, Boston, MA 02118 USA.
C3 East Tennessee State University; Boston Medical Center
RP Baharestani, M (通讯作者)，E Tennessee State Univ, Ctr Nursing Res, Roy Nicks Hall,Off 112, Johnson City, TN 37614 USA.
EM baharest@etsu.edu; vickie.dri-er@bmc.org
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NR 94
TC 0
Z9 0
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD NOV
PY 2008
SU S
BP 2
EP 15
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 382OH
UT WOS:000261614800001
DA 2026-07-24
ER
PT J
AU Steiner, CL
   Trentz, O
   Labler, L
AF Steiner, Christian Luzius
   Trentz, Otmar
   Labler, Ludwig
TI Management of Morel-Lavallee Lesion Associated with Pelvic and/or
   Acetabular Fractures
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Pelvic and acetabular fractures; Soft tissue injuries and infection;
   Wound healing; Hip fracture; Pelvis
ID VACUUM-ASSISTED CLOSURE; DEGLOVING INJURIES; DAMAGE CONTROL; WOUND
   CONTROL; TRAUMA; SEVERITY; THIGH; CARE
AB Objective: Management of Morel-Lavallee soft tissue lesion (MILL) in patients with associated pelvic and/or acetabular fractures is still under discussion. Especially, the sequence of treatment of MLL soft tissue management and osteosynthesis of pelvic and acetabular injury remains controversial.
   Methods: We report all consecutive patients with MILL associated with pelvic ring and/or acetabular fractures during an 8-year period at our hospital. Surgical access and techniques were analyzed concerning complications and outcome.
   Results: Altogether, 20 patients were included in the study. One patient was treated conservatively and MLL healed without complications; 19 patients had an operative treatment of MILL In 15 patients debridement was performed within one day after injury and in four patients with delay Of 5 days at least. Ten patients had surgery for an associated pelvic ring or acetabular fracture. In four of them MILL was operated before, in six patients simultaneously to osteosynthesis. In three patients, the same surgical approach for osteosynthesis and debridement of MLL was used; none of them showed postoperative complications. Altogether, in nine operated patients (47.4%) MLL healed without any complications. Nine operated patients presented prolonged wound healing, however, during long term follow-up, all patients showed complete healing of the MILL One patient died during resuscitive surgical procedures.
   Conclusions: We recommend debridement for early and delayed treatment of MILL Osteosynthesis during first debridement may be performed without adverse outcome. Identical surgical access for both procedures can be used. In case of repeated surgical debridement VAC (R) therapy may be a helpful tool for dead space reduction and wound conditioning.
C1 [Steiner, Christian Luzius; Trentz, Otmar; Labler, Ludwig] Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Steiner, CL (通讯作者)，Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM christian.steiner@usz.ch
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NR 29
TC 22
Z9 27
U1 0
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD DEC
PY 2008
VL 34
IS 6
BP 554
EP 560
DI 10.1007/s00068-007-7056-y
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 384EB
UT WOS:000261726000006
PM 26816279
OA Green Accepted
DA 2026-07-24
ER
PT J
AU von Rüden, C
   Benninger, E
   Mayer, D
   Trentz, O
   Labler, L
AF von Rueden, Christian
   Benninger, Emanuel
   Mayer, Dieter
   Trentz, Otmar
   Labler, Ludwig
TI Bogota-VAC - A Newly Modified Temporary Abdominal Closure Technique
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Abdominal compartment syndrome (ACS); Intra-abdominal pressure (IAP);
   Temporary abdominal closure (TAC); Vacuum-assisted closure (VAC); Volume
   reserve capacity (VRC)
ID COMPARTMENT SYNDROME; TRAUMA; PACK
AB Background: We present Bogota-VAC, a newly modified temporary abdominal closure (TAC) technique for open abdomen condition after abdominal compartment syndrome (ACS).
   Methods: A thin isolation bag (Bogota bag) and a vacuum assisted closure (VAC) system were combined. A matching bag was tension-free fixed on the abdominal fascia by fascia suture. A ring shaped black polyurethane foam of the VAC system was placed into the gap between Bogota bag, abdominal fascia and the wound edge. A constant negative topic pressure of 50-75 mmHg was used in the VAC system.
   Results: Intra-abdominal pressure (IAP: 22 +/- 2 mmHg) of four patients with ACS after severe traumatic brain injury and one patient with isolated ACS after blunt abdominal trauma decreased significantly (p = 0.01) after decompressive laparotomy and treatment with Bogota-VAC (IAP: 10 +/- 2 mmHg) and remained low, measured via urinary bladder pressure. Intracranial pressure (ICP) in the four traumatic brain injury patients decreased from 42 +/- 13 mmHg to 15 +/- 3 mmHg after abdominal decompression. Cerebral perfusion pressure (57 14 mmHg) increased to 74 +/- 2 mmHg.
   Conclusion: The advantage of the presented Bogota-VAC is leak tightness, wound conditioning (soft tissue/fascia), skin protection and facilitation of nursing in combination with highest volume reserve capacity (VRC), thus preventing recurrent increased intra-abdominal and intracranial pressure in the initial phase after decompression of ACS compared to other TAC techniques.
C1 [von Rueden, Christian; Benninger, Emanuel; Trentz, Otmar; Labler, Ludwig] Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland.
   [Mayer, Dieter] Univ Zurich Hosp, Dept Surg, Div Cardiovasc Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP von Rüden, C (通讯作者)，Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM christian.vonrueden@usz.ch
RI Mayer, Dieter/E-7617-2011
OI Mayer, Dieter/0000-0001-5933-7749
CR [Anonymous], EUR J TRAUMA
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   *WORLD SOC ABD COM, CONS DEF REC
NR 13
TC 14
Z9 14
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD DEC
PY 2008
VL 34
IS 6
BP 582
EP 586
DI 10.1007/s00068-008-8007-y
PG 5
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 384EB
UT WOS:000261726000010
PM 26816283
OA Green Accepted
DA 2026-07-24
ER
PT J
AU Lopez, G
   Clifton-Koeppel, R
   Emil, S
AF Lopez, Gregory
   Clifton-Koeppel, Robin
   Emil, Sherif
TI Vacuum-assisted closure for complicated neonatal abdominal wounds
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 41st Annual Meeting of the Pacific-Association-of-Pediatric-Surgeons
CY JUN 29-JUL 03, 2008
CL Grand Teton Natl Pk, WY
SP Pacific Assoc Pediat Surg
DE Vacuum-assisted closure; Neonates; Wounds; Complications
ID EXPERIENCE; MANAGEMENT; THERAPY
AB Background: Neonatal experience in vacuum-assisted closure (VAC) for complex abdominal wounds remains scant.
   Methods: A neonatal VAC protocol was instituted in 2004. The medical records of patients treated with this protocol for the ensuing 3 years were retrospectively reviewed. Continuous data are reported as mean +/- SD (range).
   Results: Ten VAC applications occurred in 8 neonates for a 3-year period. Gestational age and age at VAC application were 30 +/- 6.9 (24-40) weeks and 84.5 +/- 51 (21-165) days, respectively. Birth weight and weight at VAC application were 1495 +/- 1118 (615-3415) g and 3515 +/- 2118 (989-7965) g, respectively. All wound complications occurred after laparotomies (7 elective, 3 emergent). Three wounds included intestinal stomas, and 3 included enterocutaneous fistulae. Average wound area at VAC initiation was 13.6 +/- 6.0 (8.5-25) cm(2). Duration of VAC use was 19.1 +/- 15.3 (7-60) days. Vacuum-assisted closure resulted in complete wound closure in all cases and did not result in any local or systemic complications. Five patients (63%) survived to discharge.
   Conclusions: Vacuum-assisted closure for complicated abdominal wounds is safe and successful in neonates of any gestational age and birth weight. It provides effective wound management, even in the presence of stomas or enterocutaneous fistulae. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Lopez, Gregory; Clifton-Koeppel, Robin; Emil, Sherif] Univ Calif Irvine, Sch Med, Div Pediat Surg, Univ Childrens Hosp, Orange, CA 92868 USA.
C3 University of California System; University of California Irvine
RP Emil, S (通讯作者)，Montreal Childrens Hosp, Div Pediat Gen Surg, Montreal, PQ H3H 1P3, Canada.
EM sherif.emil@muhc.mcgill.ca
CR AREA MJ, 2005, PEDIAT SURG INT, V21, P532
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baharestani MM, 2007, OSTOMY WOUND MANAG, V53, P75
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   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
NR 15
TC 33
Z9 36
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD DEC
PY 2008
VL 43
IS 12
BP 2202
EP 2207
DI 10.1016/j.jpedsurg.2008.08.067
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Surgery
GA 386AC
UT WOS:000261853700014
PM 19040935
DA 2026-07-24
ER
PT J
AU Mody, GN
   Nirmal, IA
   Duraisamy, S
   Perakath, B
AF Mody, Gita N.
   Nirmal, Ida Anita
   Duraisamy, Sulochana
   Perakath, Benjamin
TI A Blinded, Prospective, Randomized Controlled Trial of Topical Negative
   Pressure Wound Closure in India
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE wounds; topical negative pressure; developing world; randomized
   controlled trial; South India
ID VACUUM-ASSISTED CLOSURE; FOOT COMPLICATIONS; THERAPY; PREVALENCE;
   MANAGEMENT; AMPUTATION; DRESSINGS
AB Wound closure using topical negative pressure (TNP) has been reported to be effective, but equipment costs can be prohibitive in resource-challenged countries. Because nonhealing wounds are exceedingly common in developing countries such as India, the ability to optimize wound care with limited resources is very important. To investigate the feasibility and efficacy of providing TNP in an Indian medical referral center, a randomized controlled trial comparing a locally constructed TNP device (treatment) to wet-to-dry gauze dressings (control) was conducted. Eligible study participants (N = 48) were recruited from the inpatient wards. Wound etiologies included diabetic foot ulcers (15), pressure ulcers (11), cellulitis/fasciitis (11), and "other" (11). Following enrollment, wound size was assessed using computer-aided measurements of digital photographs and block-randomized to the study arms using a concealed allocation table. Wounds in both treatment groups were debrided before dressing application and patients were followed until wound closure or being lost to follow-up for an average of 26.3 days (+/- 18.5) in the con trol and 33.1 days (+/- 37.3) in the treatment group. No statistically significant differences in time to closure between the two treatment groups were observed except in a subset analysis of pressure ulcers (mean 10 +/- 7.11 days for treatment and 27 +/- 10.6 days in control group, P = 0.05). Direct costs to close a pressure ulcer also were lower in the TNP than in the control group. A review of the literature suggests the outcomes obtained using a locally constructed TNP device are similar to those obtained using commercially available devices. As a result of this study, a dedicated tissue viability team has been established to identify wounds suitable for TNP oversee treatment, monitor the need for surgical debridement, and employ wound healing principles and technology appropriately. These results suggest that inexpensive materials can be utilized for TNP wound closure in a developing country.
C1 [Mody, Gita N.; Nirmal, Ida Anita; Duraisamy, Sulochana; Perakath, Benjamin] Christian Med Coll & Hosp, Dept Surg, S5 Div, Vellore, Tamil Nadu, India.
C3 Christian Medical College & Hospital (CMCH) Vellore
RP Mody, GN (通讯作者)，Brigham & Womens Hosp, Dept Surg, 75 Francis St, Boston, MA 02115 USA.
EM gmody@partners.org
RI Mody, Gita/KQV-0468-2024
OI Mody, Gita/0000-0003-0218-6948
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Smith LA, 1997, AM SURGEON, V63, P1102
   SMITH LA, 1997, AM SURGEON, V63, P7
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NR 30
TC 47
Z9 48
U1 0
U2 14
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD DEC
PY 2008
VL 54
IS 12
BP 36
EP 46
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 387ZW
UT WOS:000261991100007
PM 19104122
DA 2026-07-24
ER
PT J
AU Hamed, O
   Muck, PE
   Smith, JM
   Krallman, K
   Griffith, NM
AF Hamed, Osama
   Muck, Patrick E.
   Smith, J. Michael
   Krallman, Kelli
   Griffith, Nathan M.
TI Use of vacuum-assisted closure (VAC) therapy in treating lymphatic
   complications after vascular procedures: New approach for lymphoceles
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 36th Annual Meeting of the Society-for-Clinical-Vascular-Surgery
CY MAR 05-08, 2008
CL Las Vegas, NV
SP Soc Clin Vasc Surg
ID ARTERIAL RECONSTRUCTION; ENDOVASCULAR REPAIR; WOUND CONTROL; GROIN;
   LYMPHORRHEA; MANAGEMENT; SURGERY; SCLEROTHERAPY; FLAP; FISTULA
AB Objective: Lymphatic complications, such as lymphocutaneous fistula (LF) and lymphocele, are relatively uncommon after vascular procedures, but their treatment represents a serious challenge. Vacuum assisted closure (VAC) therapy has been reported to be an effective therapeutic option for LF, but the effectiveness of VAC therapy for lymphoceles is uncle it.
   Methods. For LF, we apply the VAC directly to the skin defect after extending it to achieve a clean wound of at least one inch in length. To treat lymphocele, we convert the lymphocele to a LF in a sterile fashion by making a one inch incision in the overlying skin and applying the VAC. The setting was a community teaching hospital. We used 10 patients that we treated with VAC therapy for LF (n = 4) and lymphoceles (n = 6).
   Results: Duration of in-patient stay, duration of in-patient VAC treatment, duration of out-patient VAC treatment, total duration of VAC treatment. The median duration of in-patient stay was 4 (range, 0-18) days, the median duration of in-patient VAC treatment was 1 (range, 0-5) days, the median duration of out-patient VAC treatment was 16 (range, 7-28) days), and the median total duration of VAC therapy was 18 (range, 13-29) days. Successful wound healing was achieved in all patients with no recurrence after VAC removal. VAC therapy for treatment of both LFs and lymphoceles resulted in early control of drainage, rapid wound closure, and short hospital stays.
   Conclusion: Our results suggest that VAC therapy is a convenient and effective therapeutic option for both LFs and lymphoceles. (J Vasc Surg 2008;48:1520-3.)
C1 [Griffith, Nathan M.] Good Samaritan Hosp, Inst Res & Educ, Cincinnati, OH 45220 USA.
   [Hamed, Osama; Muck, Patrick E.; Smith, J. Michael] Good Samaritan Hosp, Dept Gen Vasc Surg, Cincinnati, OH 45220 USA.
C3 Good Samaritan Hospital - Cincinnati; Good Samaritan Hospital -
   Cincinnati
RP Griffith, NM (通讯作者)，Good Samaritan Hosp, Inst Res & Educ, 375 Dixmyth Ave, Cincinnati, OH 45220 USA.
EM nathan_griffith@trihealth.com
RI Griffith, Nathan/JFS-3460-2023
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NR 31
TC 33
Z9 39
U1 0
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD DEC
PY 2008
VL 48
IS 6
BP 1520
EP 1523
DI 10.1016/j.jvs.2008.07.059
PG 4
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA 388FX
UT WOS:000262006800025
PM 19118737
OA Bronze
DA 2026-07-24
ER
PT J
AU Baldwin, C
   Potter, M
   Clayton, E
   Irvine, L
   Dye, J
AF Baldwin, Christopher
   Potter, Matthew
   Clayton, Elizabeth
   Irvine, Laurie
   Dye, Julian
TI Topical Negative. Pressure Stimulates Endothelial Migration and
   Proliferation A Suggested Mechanism for Improved Integration of Integra
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT 12th Congress of the British-Burns-Association
CY 2006
CL Dublin, IRELAND
SP British Burns Assoc
DE topical negative pressure; angiogenesis; wound healing; synthetic dermal
   equivalents
ID VACUUM-ASSISTED CLOSURE; DERMAL REGENERATION TEMPLATE; SUBATMOSPHERIC
   PRESSURE; EXTRACELLULAR-MATRIX; ARTIFICIAL SKIN; CLINICAL-TRIAL; TISSUE
   DEFECTS; WOUND CONTROL; ANGIOGENESIS; THERAPY
AB Topical negative pressure is an effective technique to promote wound healing and the integration of skin graft and synthetic dermal equivalents. We describe an in vitro model to investigate the effect of negative pressure on angiogenesis, a pivotal step. Dermal fibroblasts or human microvascular endothelial cells were cultured on Integra and subjected to intermittent or continuous negative pressure. At fixed intervals of over 120 hours, the Integra was fixed and assessed for cell migration (microscopy), cell viability (MTS assay), and cell proliferation (Ki67 immunostaining). Under control conditions, endothelial cells formed a monolayer and failed to ingress, whereas fibroblasts migrated throughout the Integra within 24 hours. Negative pressure switches endothelial cell to a migratory and proliferative phenotype. Ingress is greatest with intermittent rather than continuous negative pressure. It has no effect on dermal fibroblast function. This study identifies an important, potential pro-angiogenic mechanism by which topical negative pressure promotes wound healing.
C1 [Baldwin, Christopher; Potter, Matthew; Clayton, Elizabeth; Dye, Julian] Mt Vernon Hosp, Inst Plast Surg, RAFT, Northwood HA6 2RN, Middx, England.
   [Irvine, Laurie] Watford Dist Gen Hosp, Watford, England.
C3 Watford General Hospital
RP Dye, J (通讯作者)，Mt Vernon Hosp, Inst Plast Surg, RAFT, Northwood HA6 2RN, Middx, England.
EM dyej@raft.ac.uk
RI Dye, Julian Francis/U-3396-2019; Potter, Matthew/JFK-2500-2023
OI Dye, Julian Francis/0000-0001-7634-2822; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Atiyeh BS, 2005, BURNS, V31, P944, DOI 10.1016/j.burns.2005.08.023
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NR 30
TC 64
Z9 85
U1 0
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JAN
PY 2009
VL 62
IS 1
BP 92
EP 96
DI 10.1097/SAP.0b013e31817762fd
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 388NH
UT WOS:000262026000023
PM 19131729
DA 2026-07-24
ER
PT J
AU Singh, MK
   Rocca, JP
   Rochon, C
   Facciuto, ME
   Sheiner, PA
   Rodriguez-Davalos, MI
AF Singh, M. K.
   Rocca, J. P.
   Rochon, C.
   Facciuto, M. E.
   Sheiner, P. A.
   Rodriguez-Davalos, M. I.
TI Open Abdomen Management With Human Acellular Dermal Matrix in Liver
   Transplant Recipients
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article
ID ABDOMINAL-WALL; CLOSURE; SAFE
AB Background. Abdominal wall closure after liver transplantation is not always feasible and may result in increased intra-abdominal pressure along with associated complications. Various temporary Closure techniques as well as open wound management have been used to address this complex problem. The aim of this series was to describe an approach to definitive wound closure of the open abdomen in liver transplant patients.
   Methods. We performed a retrospective review of all liver transplant patients at our institution from September 2005 to November 2007. The management of the open abdomen in 10 liver transplant patients was reviewed, and a novel approach described to manage these defects.
   Results. Ten patients with open wounds were closed during the study period using human acellular dermal matrix (HADM). There were 7 men and 3 women of median age 55 years. Average size of HADM was 235 cm(2). The median follow-up is,10 months with no incidence of evisceration or hernia. In 1 patient, the graft failed along the lateral side due to infection; it dislodged during vacuum-assisted closure dressing change in another patient at 5 months after closure. Fascial closure was not possible due to organ edema (n = 3), a large liver (n = 4) or wound infection with dehiscence (n = 3).
   Conclusions. RADM can be used for primary wound closure in both clean and contaminated wounds as an alternative to an open abdomen post-liver transplantation.
C1 [Singh, M. K.; Rocca, J. P.; Rochon, C.; Facciuto, M. E.; Sheiner, P. A.; Rodriguez-Davalos, M. I.] Westchester Med Ctr, Dept Hepatobiliary & Liver Transplant, Valhalla, NY USA.
C3 Westchester Medical Center
RP Singh, MK (通讯作者)，Transplant Ctr, BHC A Wing,95 Grasslands Rd, Valhalla, NY 10595 USA.
EM msingh78@gmail.com
RI ; /AAM-6817-2021; Rocca, Juan/AAU-3771-2020
OI Singh, Manoj/0000-0002-1909-1745; 
CR An G, 2004, J TRAUMA, V56, P1266, DOI 10.1097/01.TA.0000068241.66186.00
   Buinewicz B, 2004, ANN PLAS SURG, V52, P188, DOI 10.1097/01.sap.0000100895.41198.27
   de Goyet JD, 1998, TRANSPLANT INT, V11, P117
   Jafri MA, 2007, LIVER TRANSPLANT, V13, P258, DOI 10.1002/lt.21027
   Jones WT, 2003, J PEDIATR SURG, V38, DOI 10.1016/S0022-3468(03)00524-4
   Levi DM, 2003, LANCET, V361, P2173, DOI 10.1016/S0140-6736(03)13769-5
   Oikawa K, 1998, TRANSPLANT P, V30, P3209, DOI 10.1016/S0041-1345(98)00998-1
   Ong TH, 1996, J PEDIATR SURG, V31, P295, DOI 10.1016/S0022-3468(96)90019-6
   Sclafani A P, 2001, Arch Facial Plast Surg, V3, P101, DOI 10.1001/archfaci.3.2.101
   Sclafani Anthony P, 2002, Arch Facial Plast Surg, V4, P164, DOI 10.1001/archfaci.4.3.164
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NR 12
TC 22
Z9 30
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD DEC
PY 2008
VL 40
IS 10
BP 3541
EP 3544
DI 10.1016/j.transproceed.2008.06.105
PG 4
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Surgery; Transplantation
GA 389ZE
UT WOS:000262133300061
PM 19100433
DA 2026-07-24
ER
PT J
AU Lejay, A
   Creton, O
   Thaveau, F
   Bajcz, C
   Stephan, D
   Kretz, JG
   Chakfé, N
AF Lejay, A.
   Creton, O.
   Thaveau, F.
   Bajcz, C.
   Stephan, D.
   Kretz, J. -G.
   Chakfe, N.
TI Current clinical applications of vacuum-assisted closure (VAC) in
   vascular surgery
SO JOURNAL DES MALADIES VASCULAIRES
LA French
DT Article
ID WOUND THERAPY; ISCHEMIA; TRIAL
AB The aim of the study was to evaluate the efficacy of vacuum-assisted closure (VAC) in vascular patients presenting limb ulcers or non heated amputations. The efficacy of the VAC was studied in terms of heating, walking distance, and autonomy of life. This retrospective study included 14 patients, 11 men and three women, who were treated by a VAC therapy between December 2003 and February 2007. Two patients presented critical ischemia with limb ulcers and 12 patients non heated amputations despite previous revascularisation. Vascular reconstruction was performed in all cases before the VAC therapy. The rate of wound heating with VAC therapy was 87%. After wound heating, 92% of patients were walking and 62% of them were independent. In conclusion, VAC therapy may be a useful toot to accelerate heating of lower-timb wounds or non healing wounds secondary to amputation, allowing a faster recovery with a good level of autonomy. (c) 2008 Elsevier Masson SAS.
C1 [Lejay, A.; Creton, O.; Thaveau, F.; Bajcz, C.; Kretz, J. -G.; Chakfe, N.] Ctr Hosp Reg Univ, Serv Chirurg Vasc, F-67091 Strasbourg, France.
   [Stephan, D.] Ctr Hosp Reg Univ, Serv Malad Vasc, F-67091 Strasbourg, France.
C3 CHU Strasbourg; CHU Strasbourg
RP Chakfé, N (通讯作者)，Ctr Hosp Reg Univ, Serv Chirurg Vasc, 1 Pl Hop,BP 426, F-67091 Strasbourg, France.
EM nabil.chakfe@chru-strasbourg.fr
RI Stephan, Dominique/PNF-0972-2026
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 20
TC 5
Z9 6
U1 0
U2 4
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0398-0499
J9 J MAL VASCUL
JI J. Mal. Vasc.
PD DEC
PY 2008
VL 33
IS 4-5
BP 196
EP 201
DI 10.1016/j.jmv.2008.08.002
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 390YR
UT WOS:000262200100002
PM 19019600
DA 2026-07-24
ER
PT J
AU Murphey, GC
   Macias, BR
   Hargens, AR
AF Murphey, Gary C.
   Macias, Brandon R.
   Hargens, Alan R.
TI Depth of penetration of negative pressure wound therapy into underlying
   tissues
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; INTERSTITIAL FLUID PRESSURE; SUBATMOSPHERIC
   PRESSURE; FOUNDATION
AB Negative pressure wound therapy has become ubiquitous in orthopedic surgery and it is therefore important to understand the physiologic conditions of this therapy. The purpose of this study was to determine the magnitude and depth of negative pressure transmission into underlying muscle tissue in a wound model. We hypothesized that the negative pressure is not transmitted beyond 2 mm into underlying muscle tissue. Using both an isolated muscle and a live animal wound model, we applied open cell foam dressing to the tissue. Using a series of vacuum-assisted closure negative pressure settings (0, -75, -125, -200 mmHg) interstitial fluid pressure was measured in the underlying tissue with a solid-state pressure transducer catheter at 1/10 mm depth intervals. In the ex vivo isolated-muscle model, the effect of negative pressure wound therapy on interstitial fluid pressure was extinguished and not significantly different than controls at a depth < 2 mm. In the live animal wound model, the magnitude of interstitial fluid pressures corresponded directly with negative pressure settings (p < 0.01) and inversely with depth into muscle (p < 0.01). Interstitial fluid pressures were significantly (p < 0.05) less than control interstitial fluid pressures (0 mmHg setting) at depths of 0.5, 0.4, and 0.9 mm below the foam/muscle interface when the applied pressures were -75, -125, and -200 mmHg, respectively. Negative pressure wound therapy penetrates no more than 1 mm into rabbit wound tissue at the highest negative pressure setting (-200 mmHg) when using open-cell foam dressing.
C1 [Murphey, Gary C.; Macias, Brandon R.; Hargens, Alan R.] Univ Calif San Diego, Dept Orthopaed Surg, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego
RP Hargens, AR (通讯作者)，Univ Calif San Diego, Dept Orthopaed Surg, 350 Dickinson St,Suite 121, San Diego, CA 92103 USA.
EM ahargens@ucsd.edu
FU Kinetic Concepts Inc; NIH [2 T32 AR07484-22]
FX This project was funded by a donation from Kinetic Concepts Inc. and NIH
   Training Grant 2 T32 AR07484-22. Special thanks to Dr. Kilpadi of
   Kinetic Concepts Inc. for his support and expertise. The other authors
   report no professional or financial affiliations relevant to this study.
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NR 16
TC 16
Z9 23
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN-FEB
PY 2009
VL 17
IS 1
BP 113
EP 117
DI 10.1111/j.1524-475X.2008.00448.x
PG 5
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 395EX
UT WOS:000262508500054
PM 19152658
DA 2026-07-24
ER
PT J
AU Cresti, S
   Ouaïssi, M
   Sielezneff, I
   Chaix, JB
   Pirro, N
   Berthet, B
   Consentino, B
   Sastre, B
AF Cresti, Silvia
   Ouaissi, Mehdi
   Sielezneff, Igor
   Chaix, Jean-Baptiste
   Pirro, Nicolas
   Berthet, Bruno
   Consentino, Bernard
   Sastre, Bernard
TI Advantage of vacuum assisted closure on healing of wound associated with
   omentoplasty after abdominoperineal excision: a case report
SO WORLD JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
ID FLAP RECONSTRUCTION; RESECTION; TRIAL; ADENOCARCINOMA; COMPLICATIONS;
   DEFECTS; RECTUM
AB Background: Primary closure of the perineum with drainage after abdominoperineal excision of the rectum for carcinoma, is widely accepted. However hematoma, perineal abscess and reoperation are significantly more frequent after primary closure than after packing of the perineal cavity. Those complications are frequently related to the patients' clinical antecedent (i.e radiotherapy, diabetes, smoking).
   Case presentation: In the present report, vacuum assisted drainage was used after abdominoperineal excision for carcinoma in the very first step due to intraoperative gross septic contamination during tumor resection. The first case: A 57-years old man with a 30-years history of peri-anal Crohn's disease, the adenocarcinoma of the lowest part of the rectum and Crohn colitis with multiple area of severe dysplasia required panproctocolectomy with a perineal resection. The VAC system was used during 12 days (changed every 3 days). We observed complete healing 18 days after surgery. The second case: A 51-year-old man, with AIDS. An abdominoperineal resection was performed for recurrence epidermoid anal cancer. The patient was discharged at day 25 and complete healing was achieved 30 days later after surgery.
   Conclusion: The satisfactory results showed in the present report appear to be favored by association of omentoplasty and VAC system. Those findings led us to favor VAC system in the case of pelvic exenteration associated with high risk of infection.
C1 [Cresti, Silvia; Ouaissi, Mehdi; Sielezneff, Igor; Chaix, Jean-Baptiste; Pirro, Nicolas; Berthet, Bruno; Consentino, Bernard; Sastre, Bernard] Hop Enfants La Timone, Serv Chirurg Digest & Oncol, Marseille, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille
RP Ouaïssi, M (通讯作者)，Hop Enfants La Timone, Serv Chirurg Digest & Oncol, Marseille, France.
EM sylvia.cresti@mail.ap-hm.fr; mehdi.ouaissi@mail.ap-hm.fr;
   igor.sielezneff@mail.ap.hm.fr; jeanbaptiste.chaix@mail.ap-hm.fr;
   nicolas.pirro@mail.ap-hm.fr; brunot.berthet@mail.ap.fr;
   bernard.consentino@mail.ap-hm.fr; bernard.sastre@mail.ap.hm.fr
RI CHAIX, Jordane/MXM-3911-2025; /HPF-7453-2023
FU Assistance Publique des Hopitaux de Marseille; Faculte de Medecine de
   Marseille
FX This work was supported by Assistance Publique des Hopitaux de Marseille
   and Faculte de Medecine de Marseille.
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NR 15
TC 15
Z9 23
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1477-7819
J9 WORLD J SURG ONCOL
JI World J. Surg. Oncol.
PD DEC 23
PY 2008
VL 6
AR 136
DI 10.1186/1477-7819-6-136
PG 5
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 395NU
UT WOS:000262531600001
PM 19102785
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Dhir, K
   Reino, AJ
   Lipana, J
AF Dhir, Karan
   Reino, Anthony J.
   Lipana, Jon
TI Vacuum-Assisted Closure Therapy in the Management of Head and Neck
   Wounds
SO LARYNGOSCOPE
LA English
DT Article; Proceedings Paper
CT Eastern Section Meeting of the Triologic-Society
CY JAN 25-27, 2008
CL Philadelphia, PA
SP Triol Soc
DE Vacuum-assisted closure; wound VAC; wound dehiscence; salivary leak;
   chronic wound care
ID SECURING SKIN-GRAFTS; DEVICE; SOFT
AB Objectives: The wound vacuum-assisted closure (VAC) has been used in many areas of surgery to promote healing and facilitate secondary reconstruction. Until recently, this treatment modality was overlooked in the otolaryngology literature, and the authors propose that its use should be routine in the treatment of complex head and neck wounds.
   Study Design: An unbiased cohort study without conflict of interest at two tertiary care centers.
   Materials and Methods: All patients treated by the authors presented with complex head and neck wounds from 2005 to 2007 and were subjected to wound VAC therapy. The wound VAC dressing was changed every 72 hours, and the wound etiology, wound site, history of chemotherapy and radiation, hospital duration, gender, outcome, and ancillary procedures were recorded.
   Results: Nineteen patients with 33 wounds were treated using VAC therapy. Eighty-four percent of these patients healed completely without the need for further surgical intervention. The mean age of this cohort was 63.2 years, with a range of 48-75 years. Males far outnumbered females in this study (17:2). Outpatient therapy commenced at discharge after an average of 11.4 days following a hospital stay ranging between 5 and 28 days. Adjunctive procedures performed during and after VAC therapy included hyperbaric oxygen treatment, dermal grafts, salivary diversion, and regional flap reconstruction.
   Conclusions: This study shows the applicability and versatility of vacuum-assisted wound closure in the head and neck. Based on our results the authors feel that this mode of therapy should be a routine part of the Otolaryngologist's armamentarium for the treatment of complex and refractory head and neck wounds.
C1 [Dhir, Karan; Reino, Anthony J.; Lipana, Jon] Mt Sinai Sch Med, Dept Otolaryngol Head & Neck Surg, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Reino, AJ (通讯作者)，Mt Sinai Sch Med, Dept Otolaryngol Head & Neck Surg, 1 Gustave L Levy Pl,Box 1189, New York, NY 10029 USA.
EM areino@optionline.net
CR [Anonymous], 2004, WOUNDS, p3S
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NR 28
TC 48
Z9 56
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD JAN
PY 2009
VL 119
IS 1
BP 54
EP 61
DI 10.1002/lary.20000
PG 8
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine; Otorhinolaryngology
GA 396EO
UT WOS:000262575200010
PM 19117292
DA 2026-07-24
ER
PT J
AU Park, CA
   Defranzo, AJ
   Marks, MW
   Molnar, JA
AF Park, Christopher A.
   Defranzo, Anthony J.
   Marks, Malcolm W.
   Molnar, Joseph A.
TI Outpatient Reconstruction Using Integra and Subatmospheric Pressure
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE outpatient; Integra; subatmospheric pressure; Vacuum Assisted Closure;
   VAC; VAC; wound care; reconstruction; burn contracture; skin graft
ID VACUUM-ASSISTED CLOSURE; ARTIFICIAL SKIN; WOUND CONTROL; SURGERY; TRIAL;
   BURNS
AB Integra (Integra Lifesciences Corporation, Plainsboro, NJ) has been used in a variety of reconstructive surgical procedures. The application of Integra using subatmospheric pressure (V.A.C., Kinetic Concepts, Inc, San Antonio, TX) has been suggested to be easier, faster, and more consistent than previous dressings, allowing grafting as soon as I week after Integra placement. Ten patients were chosen for outpatient reconstructive surgery with Integra and subatmospheric pressure with skin grafting 7-10 days (mean = 8 days) post-Integra. Skin graft take was 75% to 160% (mean = 91.5%). No patients required additional grafting or reconstruction. Integra may be successfully used for reconstruction of difficult areas as an outpatient in combination with subatmospheric pressure (V.A.C.). This allows for expedited treatment, decreased morbidity, and lower cost versus standard Integra application.
C1 [Park, Christopher A.; Defranzo, Anthony J.; Marks, Malcolm W.; Molnar, Joseph A.] Wake Forest Univ, Baptist Med Ctr, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Park, CA (通讯作者)，Wake Forest Univ, Baptist Med Ctr, Dept Plast & Reconstruct Surg, 1 Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM cpark@wfubmc.edu
RI Molnar, Joseph/AEK-5540-2022
FU KCI, Inc.
FX Wake Forest University School of Medicine receives royalties from the
   sale and use of the V.A.C. and distributes a portion of the royalties to
   Louis C. Argenta, MD, and Michael Motykwas, PhD. Joseph A. Molnar, MD,
   PhD, receives research funds from KCI, Inc. (the manufacturer of the
   V.A.C.), and receives compensation for presentations at educalional
   symposia sponsored by KCI, Inc.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BURKE JF, 1981, ANN SURG, V194, P413, DOI 10.1097/00000658-198110000-00005
   Clayton MC, 1998, J BURN CARE REHABIL, V19, P358, DOI 10.1097/00004630-199807000-00017
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Fang P, 2002, J BURN CARE REHABIL, V23, P327, DOI 10.1097/00004630-200209000-00005
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Grant I, 2001, BURNS, V27, P699, DOI 10.1016/S0305-4179(01)00040-7
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   Molnar JA, 2004, PLAST RECONSTR SURG, V113, P1339, DOI 10.1097/01.PRS.0000112746.67050.68
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Ryan CM, 2002, J BURN CARE REHABIL, V23, P311, DOI 10.1097/00004630-200209000-00002
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Sheridan RL, 1999, BURNS, V25, P97, DOI 10.1016/S0305-4179(98)00176-4
NR 16
TC 40
Z9 43
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2009
VL 62
IS 2
BP 164
EP 169
DI 10.1097/SAP.0b013e31817d87cb
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 397RV
UT WOS:000262680700014
PM 19158527
DA 2026-07-24
ER
PT J
AU Montecamozzo, G
   Leopaldi, E
   Baratti, C
   Previde, P
   Ferla, F
   Pizzi, M
   Sposato, J
   Pariani, D
   Sartani, A
   Trabucchi, E
AF Montecamozzo, G.
   Leopaldi, E.
   Baratti, C.
   Previde, P.
   Ferla, F.
   Pizzi, M.
   Sposato, J.
   Pariani, D.
   Sartani, A.
   Trabucchi, E.
TI Incarcerated massive incisional hernia: extensive necrosis of the colon
   in a very obese patient. Surgical treatment and vacuum-assisted closure
   therapy: a case report
SO HERNIA
LA English
DT Article
DE Massive incisional hernia; Bowel strangulation; Vacuum-assisted closure;
   Obesity
ID WOUND CONTROL; METALLOPROTEINASES
AB We discuss a diabetic obese patient with an extensive necrosis of the ascending and transverse colon plus segmental necrosis of the small bowel incarcerated in a massive median incisional hernia below the umbilicus. After a blood test and an abdominal CT scan (without contrast dial), the patient underwent an urgent operation. We performed an extended right hemicolectomy, multiple segmental small bowel resections and a terminal ileostomy. The defect of the abdominal wall was treated with vacuum-assisted closure (VAC) therapy with good results.
C1 [Montecamozzo, G.; Leopaldi, E.; Baratti, C.; Previde, P.; Ferla, F.; Pizzi, M.; Sposato, J.; Pariani, D.; Sartani, A.; Trabucchi, E.] AO Luigi Sacco Univ Milano, Chirurg Oncogastrosurg Dept 1, I-20157 Milan, Italy.
C3 University of Milan; Luigi Sacco Hospital
RP Ferla, F (通讯作者)，AO Luigi Sacco Univ Milano, Chirurg Oncogastrosurg Dept 1, Via GH Grassi 74, I-20157 Milan, Italy.
EM fabioferla@hotmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta PA, 2002, OBSTET GYNECOL, V99, P497, DOI 10.1016/S0029-7844(01)01752-5
   Baynham S A, 1999, Ostomy Wound Manage, V45, P28
   BUCKNALL TE, 1983, ANN ROY COLL SURG, V65, P71
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   DERSCH T, 1994, WOUND REPAIR REGEN, V2, P64
   DIEBEL L, 1992, AM SURGEON, V58, P573
   Korenkov M, 2001, LANGENBECK ARCH SURG, V386, P65, DOI 10.1007/s004230000182
   Korff T, 1999, J CELL SCI, V112, P3249
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   MORYKWAS MJ, 1993, ANN M FED AM SOC EXP
   Moses MA, 1996, J CELL BIOCHEM, V60, P379, DOI 10.1002/(SICI)1097-4644(19960301)60:3<379::AID-JCB9>3.3.CO;2-0
   Mutter D., 2000, Hernia, V4, pS3
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
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NR 16
TC 3
Z9 3
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD DEC
PY 2008
VL 12
IS 6
BP 641
EP 643
DI 10.1007/s10029-008-0370-4
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 398XA
UT WOS:000262763600015
PM 18427907
DA 2026-07-24
ER
PT J
AU Wagner, A
AF Wagner, Andreas
TI Use of Vacuum-Assisted Closure Therapy for the Conditioning of
   Soft-Tissue Defects
SO OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE
LA German
DT Article
DE Vacuum sealing technique; Vacuum-assisted closure; VAC therapy
AB The Problem
   Acute or chronic wounds requiring temporary wound coverage and closure.
   Soft-tissue defects unsuitable for any type of wound closure.
   Soft-tissue defects associated with infection.
   The Solution
   Temporary or definite wound closure according to a general concept for treatment of acute or chronic wounds. Support of wound healing through enhanced cell proliferation and formation of granulation tissue. Improvement of local blood circulation and eradication of infection.
   Surgical Technique
   Surgical debridement.
   Temporary wound closure with vacuum-assisted closure therapy.
   Second look with change of vacuum-assisted closure systems, irrigation and debridement procedures.
   Definitive wound closure through
   vacuum-aided wound reduction and secondary suture or
   mesh grafting or
   debridement and flap coverage.
   Results
   Embedded in the general concept of treatment algorithm for acute or chronic wounds, vacuum-assisted wound closure is part of the therapy. Vacuum therapy facilitates direct wound closure or improves wound conditioning to assist further surgical procedures.
C1 Rudolf Elle gGmbH, Waldkrankenhaus, Lehrstuhl Orthopadie, D-07607 Eisenberg, Germany.
RP Wagner, A (通讯作者)，Rudolf Elle gGmbH, Waldkrankenhaus, Lehrstuhl Orthopadie, Klosterlausnitzer Str 81, D-07607 Eisenberg, Germany.
EM XAndreasWagnerX@aol.com
CR FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Fleischmann W, 1997, UNFALLCHIRURG, V100, P301, DOI 10.1007/s001130050123
   Holle G, 2007, UNFALLCHIRURG, V110, P490, DOI 10.1007/s00113-007-1267-x
   *IQWIG, 2006, 0403 IQWIG
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
NR 6
TC 1
Z9 2
U1 0
U2 2
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0934-6694
J9 OPER ORTHOPADE TRAUM
JI Oper. Orthopade Traumatol.
PD DEC
PY 2008
VL 20
IS 6
BP 525
EP 533
DI 10.1007/s00064-008-1508-3
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 403FB
UT WOS:000263067400009
PM 19137399
DA 2026-07-24
ER
PT J
AU Dian, D
   Sommer, H
   Wilkowski, R
   Mylonas, I
   Janni, W
   Friese, K
AF Dian, D.
   Sommer, H.
   Wilkowski, R.
   Mylonas, I.
   Janni, W.
   Friese, K.
TI First Experiences with Vacuum-Assisted Closure (VAC) as Alternative
   Treatment Method to Repair Defects of the Thoracic Wall after Recurrence
   of Breast Cancer
SO GEBURTSHILFE UND FRAUENHEILKUNDE
LA German
DT Article
DE breast; cancer; recurrence; vacuum assisted closure; VAC
ID PROSPECTIVE RANDOMIZED-TRIAL; WOUND THERAPY
AB Loco-regional recurrence of mastocarcinoma is associated with a bad prognosis. Extensive and complicated surgical treatment using autologous tissue is often necessary to repair and cover defects.
   Patients and Methods: Three female patients were treated with the VAC system after undergoing resection for recurrence. In all cases local primary coverage was not possible.
   Results: In the described cases the wounds healed well during the postoperative phase. No problems with the inlying VAC systems occurred during radiation treatment or during chemotherapy.
   Conclusion: Vacuum-assisted wound closure is a potential option which allows the surgeon to avoid autologous tissue treatment in cases with extensive loco-regional recurrence.
C1 [Dian, D.; Sommer, H.; Mylonas, I.; Janni, W.; Friese, K.] Univ Frauenklin Munchen, D-80337 Munich, Germany.
C3 University of Munich
RP Dian, D (通讯作者)，Univ Frauenklin Munchen, Campus Innenstadt Maistr 11, D-80337 Munich, Germany.
EM darius.dian@med.uni-muenchen.de
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Dian D, 2006, GEBURTSH FRAUENHEILK, V66, P469, DOI 10.1055/s-2006-924112
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   Wondberg D, 2008, WORLD J SURG, V32, P2724, DOI 10.1007/s00268-008-9762-y
NR 13
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0016-5751
J9 GEBURTSH FRAUENHEILK
JI Geburtshilfe Frauenheilkd.
PD JAN
PY 2009
VL 69
IS 1
BP 50
EP 54
DI 10.1055/s-2008-1039242
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 407PF
UT WOS:000263376100008
DA 2026-07-24
ER
PT J
AU Czymek, R
   Schmidt, A
   Eckmann, C
   Bouchard, R
   Wulff, B
   Laubert, T
   Limmer, S
   Bruch, HP
   Kujath, P
AF Czymek, Ralf
   Schmidt, Andreas
   Eckmann, Christian
   Bouchard, Ralf
   Wulff, Birgit
   Laubert, Tillmann
   Limmer, Stefan
   Bruch, Hans-Peter
   Kujath, Peter
TI Fournier's gangrene: vacuum-assisted closure versus conventional
   dressings
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Fournier's gangrene; Vacuum-assisted closure; VAC; Necrotizing
   fasciitis; Fecal diversion
ID HYPERBARIC-OXYGEN THERAPY; NECROTIZING FASCIITIS; MALE GENITALIA; TISSUE
   GAS; MANAGEMENT; SCROTUM; INFECTIONS; DISEASE; BACTERIOLOGY; DIAGNOSIS
AB BACKGROUND: Fournier's gangrene is a fulminant and destructive inflammation of the scrotum, penis, and perineum. The objective of this study was to compare 2 different approaches to wound management after aggressive surgical debridement.
   METHODS: Data from 35 patients with Fournier's gangrene were prospectively collected (1996-2007). Once the patients were stabilized following surgery, they were treated with either daily antiseptic (polyhexanide) dressings (group I, n = 16) or vacuum-assisted closure (VAC) therapy (group II, n = 19).
   RESULTS: The mean age of the patients was 58.2 years in group I and 57.2 years in group II. In both groups, the most common predisposing conditions were diabetes mellitus, chronic alcoholism, and obesity. Escherichia coli, streptococcal species, Pseudomonas aeruginosa, and Staphylococcus aureus were the most frequently isolated organisms. Length of hospital stay was 27.8 days 27.6 days (mortality: 37.5%) in group I and 96.8 days 77.2 days (mortality: 5.3%) in group II. Enterostornies were performed in 43.8% of group I patients and in 89.5% of group II patients.
   CONCLUSIONS: VAC was associated with significantly longer hospitalization and lower mortality. A partial explanation is that some patients with severe sepsis died within the first 3 days after admission and thus could not undergo vacuum therapy. Since our clinical experience has shown that vacuum dressings are particularly effective in the management of large wounds, we use VAC primarily for this indication despite the considerable material requirements involved. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Czymek, Ralf; Schmidt, Andreas; Eckmann, Christian; Bouchard, Ralf; Wulff, Birgit; Laubert, Tillmann; Limmer, Stefan; Bruch, Hans-Peter; Kujath, Peter] Univ Lubeck, Sch Med, Dept Surg, D-23538 Lubeck, Germany.
C3 University of Lubeck
RP Czymek, R (通讯作者)，Univ Lubeck, Sch Med, Dept Surg, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM ralf.czymek@uk-sh.de
RI /E-7731-2010
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NR 48
TC 76
Z9 88
U1 0
U2 6
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD FEB
PY 2009
VL 197
IS 2
BP 168
EP 176
DI 10.1016/j.amjsurg.2008.07.053
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 408SA
UT WOS:000263454000008
PM 19185110
DA 2026-07-24
ER
PT J
AU Ennker, IC
   Malkoc, A
   Pietrowski, D
   Vogt, PM
   Ennker, J
   Albert, A
AF Ennker, Ina C.
   Malkoc, Anita
   Pietrowski, Detlef
   Vogt, Peter M.
   Ennker, Juergen
   Albert, Alexander
TI The concept of negative pressure wound therapy (NPWT) after
   poststernotomy mediastinitis - a single center experience with 54
   patients
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MEDIAN STERNOTOMY; CARDIAC-SURGERY; INFECTION;
   DEEP; COMPLICATIONS; MANAGEMENT; RUPTURE
AB Deep sternal infections, also known as poststernotomy mediastinitis, are a rare but often fatal complication in cardiac surgery. They are a cause of increased morbidity and mortality and have a significant socioeconomic aspect concerning the health system. Negative pressure wound therapy (NPWT) followed by muscular pectoralis plasty is a quite new technique for the treatment of mediastinitis after sternotomy. Although it could be demonstrated that this technique is at least as safe and reliable as other techniques for the therapy of deep sternal infections, complications are not absent. We report about our experiences and complications using this therapy in a set of 54 patients out of 3668 patients undergoing cardiac surgery in our institution between January 2005 and April 2007.
C1 [Ennker, Ina C.; Malkoc, Anita; Pietrowski, Detlef; Ennker, Juergen; Albert, Alexander] Abt Herzchirurg, Med Herzzentrum Lahr Baden, D-77933 Lahr, Germany.
   [Ennker, Ina C.; Vogt, Peter M.] Hannover Med Sch, Klin Plast Hand & Wiederherstellungschirurg, D-30625 Hannover, Germany.
   [Pietrowski, Detlef] Med Univ Vienna, Dept Womens Hlth, Vienna, Austria.
C3 Hannover Medical School; Medical University of Vienna
RP Ennker, IC (通讯作者)，Abt Herzchirurg, Med Herzzentrum Lahr Baden, Hohbergweg 2, D-77933 Lahr, Germany.
EM ennker@hotmail.com; anita.malkoc@heart-lahr.com;
   detlef.pietrowski@gmx.de; vogt@mh-hannover.de; ennker@heart-lahr.com;
   alexander.albert@heart-lahr.com
RI Vogt, Peter/AAL-1332-2020
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NR 21
TC 44
Z9 51
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T
   4LB, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD JAN 12
PY 2009
VL 4
AR 5
DI 10.1186/1749-8090-4-5
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 408WI
UT WOS:000263465600002
PM 19138422
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Canter, HI
   Isci, E
   Erk, Y
AF Canter, Halit Ibrahim
   Isci, Evren
   Erk, Yucel
TI Vacuum-assisted wound closure for the management of a foot ulcer due to
   Buerger's disease
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Buerger's disease; Vacuum-assisted closure; Foot ulcer; Neural island
   flap
ID THROMBOANGIITIS-OBLITERANS; FLAP COVERAGE; PATIENT
AB Thromboangiitis obliterans is a segmental inflammatory disease of the small- and medium-sized vessels mainly affecting the extremities. Although there are numerous reports concerning the treatment of these debilitating, chronic ulcers, such as skin grafting, local flaps, and free flaps, this report is the first published case of a patient with Buerger's disease, successfully managed with vacuum-assisted closure (VAC) application. This therapy decreases the period of hospital stay and increases patient comfort between dressings. Further clinical studies are needed to demonstrate the effectiveness and safety of VAC therapy in treatment of ulcers due to different kinds of vasculitis. (C) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Canter, Halit Ibrahim; Isci, Evren; Erk, Yucel] Hacettepe Univ, Fac Med, Dept Plast & Reconstruct Surg, TR-06100 Ankara, Turkey.
C3 Hacettepe University
RP Canter, HI (通讯作者)，Providence Hosp, Craniofacial Inst, Flour Fisher Ctr 3, 16001 W 9 Mite Rd,3rd Flour, Providence, MI 48075 USA.
EM hicanter@gmail.com
RI Canter, Halil Ibrahim/AFW-3691-2022; isci, evren tevfik/GYA-5663-2022
OI Canter, Halil Ibrahim/0000-0002-0329-5161; 
CR Akyürek M, 2004, PLAST RECONSTR SURG, V114, P1467, DOI 10.1097/01.PRS.0000138749.47015.E8
   Attinger C.E, 2006, PLAST RECONSTR SURG, V117
   Bozkurt A Kursat, 2004, Vascular, V12, P192
   Chang H, 2001, BRIT J PLAST SURG, V54, P76, DOI 10.1054/bjps.2000.3482
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Fisher Andrea, 2003, Issues Emerg Health Technol, P1
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   Khazanchi RK, 1999, SURG TODAY, V29, P86, DOI 10.1007/BF02482978
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   OLIN JW, 2006, CURR OPIN RHEUMATOL, V8, P8
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
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   VanLanduyt K, 1996, ANN PLAS SURG, V36, P154
NR 16
TC 0
Z9 2
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD FEB
PY 2009
VL 62
IS 2
BP 250
EP 253
DI 10.1016/j.bjps.2007.09.031
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 410QZ
UT WOS:000263594500019
PM 17980686
DA 2026-07-24
ER
PT J
AU Lumenta, DB
   Kamolz, LP
   Frey, M
AF Lumenta, David B.
   Kamolz, Lars-Peter
   Frey, Manfred
TI Adult Burn Patients With More Than 60% TBSA Involved-Meek and Other
   Techniques to Overcome Restricted Skin Harvest Availability-The Viennese
   Concept
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID POSTAGE STAMP AUTOGRAFTS; FLYPAPER TECHNIQUE; DERMAL SUBSTITUTE;
   ALLOGRAFT OVERLAY; WOUND CONTRACTION; PRESSURE THERAPY; EXTENSIVE BURNS;
   1ST EXPERIENCES; GRAFTS; ACTICOAT
AB Despite the fact that early excision and grafting has significantly improved outcome over the list decades, the management of severely burned adult patients with >= 60% total body surface area (% TBSA) burned still represents a challenging task for burn care specialists all over the world. In this article, we present our current treatment concept for this entity of severely bun-led patients and analyze its effect in a comparative cohort study. Surgical strategy comprised the use of split-thickness skin grafts (Meek, mesh) for permanent coverage, fluidized microsphere bead-beds for wound conditioning, temporary coverage (polyurethane sheets, Epigard (R); nanocrystalline silver dressings, Acticoat (R); synthetic copolymer sheets based on lactic acid, Suprathel (R); acellular bovine derived collagen matrices, Matriderm (R); allogeneic cultured keratinocyte sheets; and allogeneic split-thickness skill grafts),and negative-pressure wound therapy (vacuum-assisted closure). The autologous split-thickness skin graft expansion using the Meek technique for full-thickness burns and the delayed approach for treating dorsal burn wounds is discussed in detail. To demonstrate differences before and after the introduction of the Meek technique, we have compared patients of 2007 with >= 60% TBSA (n = 10) to those in a matched observation period (n = 7). In the first part of the comparative analysis, all patients of die two samples were analyzed with regard to age, abbreviated burn severity index, Baux, different entities of % TBSA, and survival. In die second step, only the survivors of both years were separated in two groups as follows: patients receiving skin grafts, using the Meek technique (n = 6), were compared with those without Meek grafting (n = 4). When comparing the severely burned patients of 2007 with a cohort of 2006, there were no differences for age (2007: 40.4 +/- 13.4 vs. 2006: 39.1 +/- 14.8 years), abbreviated burn severity index score (2007: 12.2 +/- 1.0 vs. 2006: 12.1 +/- 1.2) or % TBSA (2007: 72.1 +/- 11.7 vs. 2006: 69.3 +/- 8.7% TBSA). In these two rather small groups of severely burned patients with >= 60% TBSA, the overall survival rate of patients was 70.0% (7/10) in 2007 and 42.9% (3/7) in 2006, respectively. Almost all nonsurvivors in both years died within the first 5 days after admission. If assessing the different treatment modalities of till survivors, we found that although the Meek group patients were older (Meek 48.8 +/- 13.3 vs. non-Meek 26.8 +/- 11.5 years, P=.0381) and had consequently higher Bills scores (Meek 124.0 +/- 2.9 vs. non-Meek 93.8 +/- 8.5, P=.0095) than the non-Meek patients, this seemed to have no effect on length-of-stay (80.5 +/- 9.7 vs. non-Meek 79.8 +/- 33.0 days), hospital length-of-stay (85.7 +/- 14.8 vs. non-meek 84.3 +/- 26.1 days) or number of operations (6.5 +/- 1.0 vs. non-Meek 7.0 +/- 4.1 operations). The achieved results represent a combination of vinous treatment changes and, therefore, cannot be attributed to a single modality. The Meek technique is one of the technical options to choose from, to achieve permanent skin replacement; we think that it has its place if integrated in a whole treatment concept for management of severely burned patients. (J Burn Care Res 2009;30:231-242)
C1 [Lumenta, David B.; Kamolz, Lars-Peter; Frey, Manfred] Med Univ Vienna, Dept Surg, Div Plast & Reconstruct Surg, A-1090 Vienna, Austria.
C3 Medical University of Vienna
RP Kamolz, LP (通讯作者)，Med Univ Vienna, Dept Surg, Div Plast & Reconstruct Surg, Waehringer Gurtel 18-20, A-1090 Vienna, Austria.
RI Lumenta, David/AAD-5935-2019
OI Kamolz, Lars-Peter/0000-0002-5975-876X
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NR 54
TC 68
Z9 81
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2009
VL 30
IS 2
BP 231
EP 242
DI 10.1097/BCR.0b013e318198a2d6
PG 12
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 412QI
UT WOS:000263738900004
PM 19165111
DA 2026-07-24
ER
PT J
AU Weinand, C
AF Weinand, Christian
TI The Vacuum-Assisted Closure (VAC) Device for Hastened Attachment of a
   Superficial Inferior-Epigastric Flap to Third-Degree Burns on Hand and
   Fingers
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID NEGATIVE-PRESSURE DRESSINGS; SUBATMOSPHERIC PRESSURE; UPPER EXTREMITY;
   THERAPY; COVERAGE; PEDICLE; RECONSTRUCTION; BOLSTER; TRIAL
AB The vacuum-assisted closure (VAC) device has a wide range of clinical applications, including treatment of infected surgical wounds, traumatic wounds, pressure ulcers, wounds with exposed bone and hardware, diabetic foot ulcers, and venous stasis ulcers. Increased release of growth factors has been described, leading to improved vascularization and thereby formation of new tissue. The system is also used in burn surgery for reconstructive purposes. In this case report, a patient suffered from a third-degree burn injury to the dorsum of the hand with exposure of tendons, necessitating the use of a flap reconstruction. The patient was treated with a superficial inferior-epigastric artery-based flap and the VAC system was applied in a created glove-like shape. Hastened attachment of the flap onto the exposed fingers was observed after 4 days. The author reports on the additional use of the VAC system to hasten flap attachment in a patient with a burn injury to the dorsum of the hand. (J Burn Care Res 2009;30:362-365)
C1 Washington Hosp Ctr, Burns Dept, Div Burns, Washington, DC 20010 USA.
C3 MedStar Washington Hospital Center
RP Weinand, C (通讯作者)，Washington Hosp Ctr, Burns Dept, Div Burns, 110 Irving St NW, Washington, DC 20010 USA.
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NR 33
TC 8
Z9 11
U1 2
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2009
VL 30
IS 2
BP 362
EP 365
DI 10.1097/BCR.0b013e318198a77e
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 412QI
UT WOS:000263738900027
PM 19242270
DA 2026-07-24
ER
PT J
AU Yang, Z
   Liu, M
   Zhang, YG
   Guo, X
   Xu, P
AF Yang, Zhi
   Liu, Miao
   Zhang, Yin-gang
   Guo, Xiong
   Xu, Peng
TI Effects of intermittent negative pressure on osteogenesis in human bone
   marrow-derived stroma cells
SO JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
LA English
DT Article
DE Negative pressure; Bone marrow-derived stroma cells (BMSCs);
   Osteogenesis
ID VACUUM-ASSISTED CLOSURE; SHEAR-STRESS; IN-VITRO; ANGIOGENESIS; THERAPY;
   HYPOXIA
AB We investigated the effects of intermittent negative pressure on osteogenesis in human bone marrow-derived stroma cells (BMSCs) in vitro.
   BMSCs were isolated from adult marrow donated by a hip osteoarthritis patient with prosthetic replacement and cultured in vitro. The third passage cells were divided into negative pressure treatment group and control group. The treatment group was induced by negative pressure intermittently (pressure: 50 kPa, 30 min/times, and twice daily). The control was cultured in conventional condition. The osteogenesis of BMSCs was examined by phase-contrast microscopy, the determination of alkaline phosphatase (ALP) activities, and the immunohistochemistry of collagen type I. The mRNA expressions of osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) in BMSCs were analyzed by real-time polymerase chain reaction (PCR)
   BMSCs showed a typical appearance of osteoblast after 2 weeks of induction by intermittent negative pressure, the activity of ALP increased significantly, and the expression of collagen type I was positive. In the treatment group, the mRNA expression of OPG increased significantly (P < 0.05) and the mRNA expression of OPGL decreased significantly (P < 0.05) after 2 weeks, compared with the control.
   Intermittent negative pressure could promote osteogenesis in human BMSCs in vitro.
C1 [Yang, Zhi; Liu, Miao; Zhang, Yin-gang] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Orthopaed, Xian 710061, Peoples R China.
   [Guo, Xiong] Xi An Jiao Tong Univ, Inst Environm & Endem Dis, MOE Key Lab Environm & Genes Related Dis, Xian 710061, Peoples R China.
   [Xu, Peng] Xi An Jiao Tong Univ, Sch Mat Sci & Engn, Xian 710061, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong
   University
RP Zhang, YG (通讯作者)，Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Orthopaed, Xian 710061, Peoples R China.
EM xgcgfd@126.com
RI Yang, Zhibo/J-1831-2017
OI Xu, Peng/0000-0003-2487-9163
FU Postdoctoral Science Foundation of China [20070421123]
FX Project (No. 20070421123) supported by the Postdoctoral Science
   Foundation of China
CR Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
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NR 21
TC 14
Z9 19
U1 0
U2 10
PU ZHEJIANG UNIV
PI HANGZHOU
PA EDITORIAL BOARD, 20 YUGU RD, HANGZHOU, 310027, PEOPLES R CHINA
SN 1673-1581
EI 1862-1783
J9 J ZHEJIANG UNIV-SC B
JI J. Zhejiang Univ.-SCI. B
PD MAR
PY 2009
VL 10
IS 3
BP 188
EP 192
DI 10.1631/jzus.B0820240
PG 5
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Research & Experimental Medicine
GA 416AW
UT WOS:000263978600005
PM 19283873
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Karoo, ROS
   Shariff, Z
   Stanley, PRW
AF Karoo, R. O. S.
   Shariff, Z.
   Stanley, P. R. W.
TI DuoDERM strip border - A new technique for Vacuum-assisted closure in
   complex facial wounds
SO BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
LA English
DT Article
DE Vacuum Assisted Closure; Facial Wounds; Duoderm; VAC
C1 [Karoo, R. O. S.; Shariff, Z.; Stanley, P. R. W.] Castle Hill Hosp, Kingston Upon Hull, N Humberside, England.
C3 University of Hull
EM richardkaroo@hotmail.com
CR Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
NR 2
TC 1
Z9 1
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0266-4356
EI 1532-1940
J9 BRIT J ORAL MAX SURG
JI Br. J. Oral Maxillofac. Surg.
PD MAR
PY 2009
VL 47
IS 2
BP 163
EP 164
DI 10.1016/j.bjoms.2008.07.200
PG 2
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 416YN
UT WOS:000264041500024
PM 18778879
DA 2026-07-24
ER
PT J
AU Flandrin, A
   Rouleau, C
   Azar, C
   Dubon, O
   Ludovic, P
AF Flandrin, Anaig
   Rouleau, Caroline
   Azar, Chaible
   Dubon, Olivier
   Ludovic, Pierre
TI First Report of a Necrotising Fasciitis of the Breast Following a Core
   Needle Biopsy
SO BREAST JOURNAL
LA English
DT Article
DE breast; core needle biopsy; necrotising fasciitis; vacuum therapy
ID VACUUM-ASSISTED CLOSURE
AB Necrotising fasciitis (NF) is the most aggressive form of soft tissue infection. We report the first case of NF of the breast following a core needle biopsy. Aggressive management including surgical debridement and vacuum therapy allowed wound healing and breast conservation.
C1 [Flandrin, Anaig; Azar, Chaible; Dubon, Olivier; Ludovic, Pierre] Hop Arnaud de Villeneuve, Dept Obstet & Gynecol, Oncol Unit, F-34295 Montpellier 5, France.
   [Rouleau, Caroline] Hop Lapeyronie, Dept Pathol, Montpellier 5, France.
C3 Universite de Montpellier; CHU de Montpellier; Universite de
   Montpellier; CHU de Montpellier
RP Ludovic, P (通讯作者)，Hop Arnaud de Villeneuve, Dept Obstet & Gynecol, Oncol Unit, F-34295 Montpellier 5, France.
EM pl.giacalone@cegetel.net
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NR 17
TC 30
Z9 31
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1075-122X
EI 1524-4741
J9 BREAST J
JI Breast J.
PD MAR-APR
PY 2009
VL 15
IS 2
BP 199
EP 201
DI 10.1111/j.1524-4741.2009.00697.x
PG 3
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA 417PG
UT WOS:000264087900013
PM 19292808
DA 2026-07-24
ER
PT J
AU Lohsiriwat, V
AF Lohsiriwat, Varut
TI Persistent perineal sinus: Incidence, pathogenesis, risk factors, and
   management
SO SURGERY TODAY
LA English
DT Review
DE Pathogenesis; Persistent perineal sinus; Risk factors; Treatment
ID INFLAMMATORY-BOWEL-DISEASE; ABDOMINOPERINEAL RECTAL EXCISION; ABDOMINIS
   MYOCUTANEOUS FLAP; PERIANAL CROHNS-DISEASE; VACUUM-ASSISTED CLOSURE;
   RESTORATIVE PROCTOCOLECTOMY; PREOPERATIVE RADIOTHERAPY; WOUND
   COMPLICATIONS; CONTROLLED TRIAL; POUCH EXCISION
AB This review discusses the incidence, pathogenesis, risk factors, diagnosis, and therapeutic options for persistent perineal sinus (PPS), defined as a perineal wound that remains unhealed more than 6 months after surgery. The incidence of PPS after surgery for inflammatory bowel disease (IBD) ranges from 3% to 70% and after abdominoperineal resection (APR) for low rectal cancer, it can be up to 30%. These unhealed wounds are frequently related to perioperative pelvic or perineal sepsis. Crohn's disease (CD) and neoadjuvant radiation therapy are also important risk factors. The management of PPS is based on an understanding of pathogenesis and clinical grounds. The advantages and disadvantages of the current therapeutic approaches, including the topical administration of various drugs, vacuum-assisted closure, and perineal reconstruction with a muscle flap or a myocutaneous flap are also discussed.
C1 Mahidol Univ, Dept Surg, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand.
C3 Mahidol University
RP Lohsiriwat, V (通讯作者)，Mahidol Univ, Dept Surg, Fac Med, Siriraj Hosp, Prannok Rd, Bangkok 10700, Thailand.
RI Lohsiriwat, Varut/AAD-7143-2019
OI Lohsiriwat, Varut/0000-0002-2252-9509
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NR 48
TC 24
Z9 31
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
J9 SURG TODAY
JI Surg. Today
PD MAR
PY 2009
VL 39
IS 3
BP 189
EP 193
DI 10.1007/s00595-008-3846-z
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 418GI
UT WOS:000264136300002
PM 19280276
DA 2026-07-24
ER
PT J
AU Burda, R
   Kitka, M
AF Burda, R.
   Kitka, M.
TI Osteoplastic static thumb replacement for the total traumatic thumb loss
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE failed thumb replantation; thumb reconstruction; hand infection; vacuum
   assisted closure in septic hand
ID RECONSTRUCTION
AB Despite the fact that replantation of the thumb is at present a common procedure, occasionally due to the different reasons replantation is unsuccessful. We present a case where we have to cope with complete thenar loss and following reconstruction was done in an unusual way. Primarily we have covered the thenar defect with inguinal flap and secondarily we have made thumb bone replacement with heterogenous bone block fixed to the second metacarpal bone. We would like to point out that sometimes it is necessary to make reconstructions by unusual way
C1 [Burda, R.; Kitka, M.] Fac Hosp Louis Pasteur, Dept Trauma Surg, SK-04080 Kosice, Slovakia.
RP Burda, R (通讯作者)，Fac Hosp Louis Pasteur, Dept Trauma Surg, Rastislavova 43, SK-04080 Kosice, Slovakia.
EM burda@netkosice.sk
RI Burda, Rastislav/AAJ-4414-2020
OI Burda, Rastislav/0000-0003-2856-2796; Kitka,
   Miroslav/0000-0003-2614-1496
CR ASCHE C, 1980, HANDCHIRURGIE, V12, P257
   Brenner P, 1997, SCAND J PLAST RECONS, V31, P165, DOI 10.3109/02844319709085484
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NR 14
TC 1
Z9 1
U1 0
U2 0
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2009
VL 110
IS 1
BP 38
EP 42
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 418OY
UT WOS:000264159100008
PM 19408829
DA 2026-07-24
ER
PT J
AU McNulty, AK
   Schmidt, M
   Feeley, T
   Villanueva, P
   Kieswetter, K
AF McNulty, Amy K.
   Schmidt, Marisa
   Feeley, Teri
   Villanueva, Patricia
   Kieswetter, Kris
TI Effects of negative pressure wound therapy on cellular energetics in
   fibroblasts grown in a provisional wound (fibrin) matrix
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID FACTOR-BB; MULTICENTER; LACTATE; CLOSURE
AB Negative pressure wound therapy (NPWT) using reticulated open cell foam dressing (ROCF) is effective for treatment of recalcitrant wounds; however, the effects of this therapy on cellular metabolism remain to be elucidated. The effect of two different subatmospheric pressure applications on the cell energetics of human fibroblasts grown in a 3D fibrin matrix was studied using two different pressure-manifolding materials, an ROCF or gauze under suction (GUS). It was found that levels of cytochrome c oxidase, energy charge, and adenosine triphosphate/adenosine diphosphate were significantly increased following the application of NPWT using ROCF vs. GUS (p < 0.05). Increases in these parameters likely reflect an improved energetic status. In addition, levels of transforming growth factor-beta and platelet-derived growth factor (alpha and beta isoforms) were significantly increased ( 80 and 53%, respectively; p < 0.05) over static control cultures following treatment with NPWT using ROCF but not following GUS. These growth factors are known to be important during wound healing. Clearly, both the material used as the dressing to manifold the subatmospheric pressure and the pressure used have a dramatic effect on cellular response.
C1 [McNulty, Amy K.; Schmidt, Marisa; Feeley, Teri; Villanueva, Patricia; Kieswetter, Kris] Kinet Concepts Inc, Res & Dev, San Antonio, TX 78249 USA.
RP McNulty, AK (通讯作者)，Kinet Concepts Inc, Res & Dev, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM amy.mcnulty@kci1.com
FU Kinetic Concepts International
FX Funding was provided by Kinetic Concepts International.
CR Armstrong David G, 2007, Int Wound J, V4, P79, DOI 10.1111/j.1742-481X.2006.00270.x
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NR 33
TC 66
Z9 80
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2009
VL 17
IS 2
BP 192
EP 199
DI 10.1111/j.1524-475X.2009.00460.x
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 418ZJ
UT WOS:000264188600007
PM 19320887
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Ingemansson, R
   Martin, R
   Huddleston, E
AF Malmsjo, Malin
   Ingemansson, Richard
   Martin, Robin
   Huddleston, Elizabeth
TI Negative-pressure wound therapy using gauze or open-cell polyurethane
   foam: Similar early effects on pressure transduction and tissue
   contraction in an experimental porcine wound model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; STRESS; STATE; VEGF
AB Negative-pressure wound therapy (NPWT), also known as topical negative-pressure therapy, is widely used to manage wounds and accelerate healing. NPWT has so far been delivered mainly via open-cell polyurethane foam, but increasing interest has been directed toward delivering NPWT via gauze. In the present study, the early effects of NPWT on pressure transduction and wound contraction were examined in wounds filled with either polyurethane foam or gauze. An experimental setup of a porcine wound model was used, in which the animals were anesthetized for 12-14 hours. Negative pressures between -50 and -175 mmHg were applied in -25 mmHg increments. Wound bed pressure was measured using a saline filled catheter sutured to the bottom of the wound. The contraction of the wound edges was also determined. The recordings were performed upon reaching steady state, which typically occurred within 1 minute. For both fillers, wound bed negative pressure increased linearly with delivered vacuum with little deviation from set pressure ( correlation coefficient 0.99 in both cases). Similar tissue contraction was observed when using foam and gauze. The most prominent contraction was observed in the range of 0 to -50 mmHg with greater vacuum only producing minor further movement of the wound edge. In conclusion, the present experimental study shows that gauze and foam are equally effective at delivering negative pressure and creating mechanical deformation of the wound.
C1 [Malmsjo, Malin] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
   [Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Martin, Robin; Huddleston, Elizabeth] Smith & Nephew Med Ltd, Kingston Upon Hull, N Humberside, England.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Smith & Nephew
RP Malmsjö, M (通讯作者)，Vasc Res, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
OI Ingemansson, Richard/0000-0001-7623-8953; Martin,
   Robin/0000-0002-9314-0437; Maljö, Malin/0000-0001-9849-9599
FU Ake Wiberg Foundation; M. Bergvall Foundation; Anna-Lisa and Sven Erik
   Lundgrens Foundation; Smith & Nephew Medical Limited
FX This study was supported by the Ake Wiberg Foundation, the M. Bergvall
   Foundation, the Anna-Lisa and Sven Erik Lundgrens Foundation, and Smith
   & Nephew Medical Limited. The authors would like to thank Gary Smith,
   Neill Bannister, and Martin Richardson for technical input into the
   study.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 22
TC 85
Z9 98
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2009
VL 17
IS 2
BP 200
EP 205
DI 10.1111/j.1524-475X.2009.00461.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 418ZJ
UT WOS:000264188600008
PM 19320888
DA 2026-07-24
ER
PT J
AU Timmers, MS
   Graafland, N
   Bernards, AT
   Nelissen, RGHH
   van Dissel, JT
   Jukema, GN
AF Timmers, Michael S.
   Graafland, Niels
   Bernards, Alexandra T.
   Nelissen, Rob G. H. H.
   van Dissel, Jaap T.
   Jukema, Gerrolt N.
TI Negative pressure wound treatment with polyvinyl alcohol foam and
   polyhexanide antiseptic solution instillation in posttraumatic
   osteomyelitis
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EXPERIENCE; THERAPY; INFECTIONS;
   TRIAL; BONE; FOOT
AB In a retrospective, case control cohort study an assessment was made of the clinical outcome of patients with osteomyelitis treated with a new modality of negative pressure wound therapy, so called negative pressure instillation therapy. In this approach, after surgical debridement, a site of osteomyelitis is treated with negative pressure of at least 300 mmHg applied through polyvinyl alcohol dressing. The polyvinyl alcohol foam is irrigated through the tubes three times a day with a polyhexanide antiseptic solution. In 30 patients ( 14 males; mean age 52 [ range, 26-81]) admitted between 1999 and 2003 with osteomyelitis of the pelvis or lower extremity, we assessed time to wound closure, number of surgical procedures and rate of recurrence of infection as well as need for rehospitalizations. For comparison, a control group of 94 patients ( males, 58; mean age 47 [ range, 9-85]), matched for site and severity of osteomyelitis, was identified in hospital records between 1982 and 2002. These patients underwent standard surgical debridement, implantation of gentamicin polymethylmethacrylate beads and long-term intravenous antibiotics. In the Instillation group the rate of recurrence of infection was 3/30 (10%), whereas 55/93 (58.5%) of the controls had a recurrence (p < 0.0001). Moreover, in those treated with instillation the total duration of hospital stay was shorter and number of surgical procedures smaller as compared with the controls ( all p < 0.0001). We conclude that in posttraumatic osteomyelitis negative pressure instillation therapy reduces the need for repeated surgical interventions in comparison with the present standard approach.
C1 [Timmers, Michael S.; Graafland, Niels; Jukema, Gerrolt N.] Free Univ Amsterdam, Dept Trauma Surg, Med Ctr, Amsterdam, Netherlands.
   [Timmers, Michael S.; Jukema, Gerrolt N.] Leiden Univ, Sect Traumatol, Dept Surg, Med Ctr, Leiden, Netherlands.
   [Bernards, Alexandra T.] Leiden Univ, Med Ctr, Dept Med Microbiol, Leiden, Netherlands.
   [Nelissen, Rob G. H. H.] Leiden Univ, Med Ctr, Dept Orthopaed Surg, Leiden, Netherlands.
   [van Dissel, Jaap T.] Leiden Univ, Med Ctr, Dept Infect Dis, Leiden, Netherlands.
C3 Vrije Universiteit Amsterdam; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University -
   Excl LUMC; Leiden University; Leiden University Medical Center (LUMC);
   Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University;
   Leiden University Medical Center (LUMC)
RP Jukema, GN (通讯作者)，Vrije Univ Amsterdam, Med Ctr, Dept Trauma Surg, NL-1007 MB Amsterdam, Netherlands.
EM g.jukema@vumc.nl
RI Nelissen, Rob/AAD-8134-2020
OI Nelissen, Rob/0000-0003-1228-4162
FU Kinetic Concepts Inc. (KCI), San Antonio, TX
FX Conflict of interest: M. S. Timmers, N. M. Graafland, A. T. Bernards, J.
   T. van Dissel, and G. N. Jukema received unrestricted research grants
   from Kinetic Concepts Inc. (KCI), San Antonio, TX. KCI did not provide
   funding for the study reported in this paper.
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NR 29
TC 101
Z9 116
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2009
VL 17
IS 2
BP 278
EP 286
DI 10.1111/j.1524-475X.2009.00458.x
PG 9
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 418ZJ
UT WOS:000264188600017
PM 19320897
DA 2026-07-24
ER
PT J
AU Labler, L
   Rancan, M
   Mica, L
   Härter, L
   Mihic-Probst, D
   Keel, M
AF Labler, Ludwig
   Rancan, Mario
   Mica, Ladislav
   Haerter, Luc
   Mihic-Probst, Daniela
   Keel, Marius
TI Vacuum-Assisted Closure Therapy Increases Local Interleukin-8 and
   Vascular Endothelial Growth Factor Levels in Traumatic Wounds
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Vacuum-assisted closure; Epigard; Trauma; Wound; Cytokines
ID SMOOTH-MUSCLE CELLS; CARDIAC MYOCYTES; HUMAN SKIN; EXPRESSION; VEGF;
   CHEMOKINES; RECEPTORS; HYPEROXIA; HYPOXIA; INJURY
AB Background: Clinical observations are suggesting accelerated granulation tissue formation in traumatic wounds treated with vacuum-assisted closure (VAC). Aim of this study was to determine the impact of VAC therapy versus alternative Epigard application on local inflammation and neovascularization in traumatic soft tissue wounds.
   Methods: Thirty-two patients with traumatic wounds requiring temporary coverage (VAC n = 16; Epigard n = 16) were included. At each change of dressing, samples of wound fluid and serum were collected (n = 80). The cytokines interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF), and fibroblast growth factor-2 were measured by ELISA. Wound biopsies were examined histologically for inflammatory cells and degree of neovascularization present.
   Results: All cytokines were found to be elevated in wound fluids during both VAC and Epigard treatment, whereas serum concentrations were negligible or not detectable. In wound fluids, significantly higher IL-8 (p < (1.001) and VEGF (p < 0.05) levels were detected during VAC therapy. Furthermore, histologic examination revealed increased neovascularization (p < 0.05) illustrated by CD31 and von Willebrand factor immunohistochemistry in wound biopsies of VAC treatment. In addition, there was an accumulation of neutrophils as well as an augmented expression of VEGF (p < 0.005) in VAC wound biopsies.
   Conclusion: This study suggests that VAC therapy of traumatic wounds leads to increased local IL-8 and VEGF concentrations, which may trigger accumulation of neutrophils and angiogenesis and thus, accelerate neovascularization.
C1 [Labler, Ludwig; Rancan, Mario; Mica, Ladislav; Haerter, Luc; Keel, Marius] Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland.
   [Mihic-Probst, Daniela] Univ Zurich Hosp, Dept Surg Pathol, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP Keel, M (通讯作者)，Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM marius.keel@usz.ch
RI Mihic-Probst, Daniela/AAB-6374-2021
OI Mihic-Probst, Daniela/0000-0002-2215-9958
FU Swiss National Foundation (SNF) [3200B0-105987/1]; UBS, Switzerland
FX This work was supported by grant 3200B0-105987/1 from Swiss National
   Foundation (SNF) and UBS, Switzerland.
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NR 40
TC 133
Z9 169
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD MAR
PY 2009
VL 66
IS 3
BP 749
EP 757
DI 10.1097/TA.0b013e318171971a
PG 9
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 419ZU
UT WOS:000264259000027
PM 19276749
OA Green Accepted
DA 2026-07-24
ER
PT J
AU Payne, JL
   Ambrosio, AM
AF Payne, Joanna L.
   Ambrosio, Archel M.
TI Evaluation of an Antimicrobial Silver Foam Dressing for Use With VAC®
   Therapy: Morphological, Mechanical, and Antimicrobial Properties
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE VAC therapy; silver; antimicrobial activity; morphology; wound healing
ID VACUUM-ASSISTED CLOSURE; NANOCRYSTALLINE SILVER
AB The V.A.C.(R) Therapy System (KCI, San Antonio, TX) is an integrated wound management system that creates an environment that promotes wound healing. V.A.C. GranuFoam Silver (R) dressing (S-ROCF) is a reticulated, open-celled polyurethane foam having a pore size range of 400-600 mu m. The foam is coated with silver to impart antimicrobial properties throughout the dressing. The morphological and key mechanical properties including tensile strength, ultimate elongation, tear strength, and compression resistance of this dressing were compared to the original V.A.C.(R)) GranuFoam( dressing (ROCF), Which is also a reticulated, open-celled polyurethane foam, and were found to be comparable. Furthermore, the antimicrobial property of S-ROCF was evaluated in vitro for efficacy against pathogens commonly found in clinical settings, including Staphylococcus aureus and Pseudomonas aeruginosa. S-ROCF was found to be effective during antimicrobial testing with a 99.99% reduction in colony forming units, and remained effective after 72 h of simulated V.A.C. Therapy. The antimicrobial and mechanical characteristics of the foam were unaffected by aging as demonstrated through an accelerated aging process. The V.A.C. GranuFoam Silver (R) dressing is a specialized antimicrobial dressing for use with the V.A.C. Therapy System that exhibits morphological and mechanical properties comparable to the V.A.C. GranuFoam dressing and provides the added benefit of antimicrobial efficacy. (C) 2008 Wiley, Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 89B: 217-222, 2009
C1 [Payne, Joanna L.; Ambrosio, Archel M.] Kinetic Concepts Inc, Global R&D, San Antonio, TX USA.
RP Ambrosio, AM (通讯作者)，Kinetic Concepts Inc, Global R&D, San Antonio, TX USA.
EM archel.ambrosio@kci1.com
CR AMBROSIO AA, 2006, 2006 ANN M SOC BIOM
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Dannenberg R, 2000, THIN SOLID FILMS, V370, P54, DOI 10.1016/S0040-6090(99)00947-5
   Driver Vickie R, 2004, Ostomy Wound Manage, V50, p11S
   Greenhall M, 2006, HIST TODAY, V56, P22
   Heggers John P., 1992, Journal of Burn Care and Rehabilitation, V13, P512, DOI 10.1097/00004630-199209000-00003
   Kizuka T, 1997, J MATER SCI, V32, P1501, DOI 10.1023/A:1018566303784
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Ovington Liza G, 2004, Ostomy Wound Manage, V50, p1S
   Patel CTC, 2000, AM J NURS, V100, P45, DOI 10.2307/3522190
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Taylor PL, 2005, BIOMATERIALS, V26, P7221, DOI 10.1016/j.biomaterials.2005.05.040
NR 12
TC 33
Z9 34
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD APR
PY 2009
VL 89B
IS 1
BP 217
EP 222
DI 10.1002/jbm.b.31209
PG 6
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 422XE
UT WOS:000264460200026
PM 19274724
DA 2026-07-24
ER
PT J
AU Long, MA
   Blevins, A
AF Long, Mary Arnold
   Blevins, Anne
TI Options in Negative Pressure Wound Therapy Five Case Studies
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
C1 [Long, Mary Arnold; Blevins, Anne] Drake Ctr, Cincinnati, OH 45216 USA.
RP Long, MA (通讯作者)，Drake Ctr, 151 Galbraith Rd, Cincinnati, OH 45216 USA.
EM mary.long@healthall.com
CR BROCK W, 1991, AM SURGEON, V61, P30
   Campbell PE, 2006, J WOUND OSTOMY CONT, V33, P176, DOI 10.1097/00152192-200603000-00014
   CHARIKER M E, 1989, Contemporary Surgery, V34, P59
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   Kostiuchenko II, 1986, VESTNIK KHIRURGII, V9, P18
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NR 13
TC 3
Z9 4
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAR-APR
PY 2009
VL 36
IS 2
BP 202
EP 211
DI 10.1097/01.WON.0000347664.10217.2e
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 423LZ
UT WOS:000264499100011
PM 19287271
DA 2026-07-24
ER
PT J
AU Zannis, J
   Angobaldo, J
   Marks, M
   DeFramzo, A
   David, L
   Molnar, J
   Argenta, L
AF Zannis, John
   Angobaldo, Jeff
   Marks, Malcolm
   DeFramzo, Anthony
   David, Lisa
   Molnar, Joseph
   Argenta, Louis
TI Comparison of Fasciotomy Wound Closures Using Traditional Dressing
   Changes and the Vacuum-Assisted Closure Device
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE fasciotomy; VAC; wet-to-dry dressings; primary closure
ID DELAYED PRIMARY CLOSURE; COMPARTMENT SYNDROME
AB Fasciotomy wounds can be a major contributor to length of stay for patients as well as a difficult reconstructive challenge. Once the compartment pressure has been relieved and stabilized, the wound should be closed as quickly and early as possible to avoid later complications. Skin grafting can lead to morbidity and scarring at both the donor and fasciotomy site. Primary closure results in a more functional and esthetic outcome with less morbidity for the patient, but can often be difficult to achieve secondary to edema, skin retraction, and skin edge necrosis. Our objective was to examine fasciotomy wound outcomes, including time to definitive closure, comparing traditional wet-to-dry dressings, and the vacuum-assisted closure (VAC) device.
   This retrospective chart review included a consecutive series of patients over a 10-year period. This series included 458 patients who underwent 804 fasciotomies. Of these fasciotomy wounds, 438 received exclusively VAC. dressings, 270 received only normal saline wet-to-dry dressings, and 96 were treated with a combination of both. Of the sample, 408 patients were treated with exclusively VAC therapy or wet-to-dry dressings and 50 patients were treated with a combination of both.
   In comparing all wounds, there was a statistically significant higher rate of primary closure using the VAC versus traditional wet-to-dry dressings (P < 0.05 for lower extremities and P < 0.03 for upper extremities). The time to primary closure of wounds was shorter in the VAC. group in comparison with the non-VAC group.
   This study has shown that the use of the VAC for fasciotomy wound closure results in a higher rate of primary closure versus traditional wet-to-dry dressings. In addition, the time to primary closure of wounds or time to skin grafting is shorter when the VAC was employed. The VAC used in the described settings decreases hospitalization time, allows for earlier. rehabilitation, and ultimately leads to increased patient satisfaction.
C1 [Zannis, John; Angobaldo, Jeff; Marks, Malcolm; DeFramzo, Anthony; David, Lisa; Molnar, Joseph; Argenta, Louis] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27106 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Argenta, L (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27106 USA.
EM largenta@wfubmc.edu
RI Molnar, Joseph/AEK-5540-2022
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BOXER LK, 2003, INTERNET J PLAST SUR, V1, P2
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   Narayanan K, 1996, INJURY, V27, P449, DOI 10.1016/0020-1383(96)00029-0
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
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   Van der Velde M, 2005, ANN PLAS SURG, V55, P660, DOI 10.1097/01.sap.0000187181.59748.19
   Velmahos GC, 1997, WORLD J SURG, V21, P247, DOI 10.1007/s002689900224
   Willsey DB, 1997, J CLIN ANESTH, V9, P428, DOI 10.1016/S0952-8180(97)00073-1
   Zorrilla P, 2005, J TRAUMA, V59, P1515, DOI 10.1097/01.ta.0000199242.24511.30
NR 18
TC 88
Z9 138
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD APR
PY 2009
VL 62
IS 4
BP 407
EP 409
DI 10.1097/SAP.0b013e3181881b29
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 423OA
UT WOS:000264504400016
PM 19325346
DA 2026-07-24
ER
PT J
AU Stiefel, D
   Schiestl, CM
   Meuli, M
AF Stiefel, Dorothea
   Schiestl, Clemens M.
   Meuli, Martin
TI The positive effect of negative pressure: vacuum-assisted fixation of
   Integra artificial skin for reconstructive surgery
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Vacuum-assisted closure system; Negative pressure; Reconstructive
   surgery; Pediatric patients; Integra artificial skin; Skin substitute
ID DRESSINGS; DERMIS
AB Background: Integra artificial skin (Integra) (Integra Life Sciences Corporation, Plainsboro, NJ) is increasingly used as a skin substitute in reconstructive surgery. However, reliable fixation to the wound bed, a factor of paramount importance for successful application, is often hard to achieve. The vacuum-assisted closure system (VAC; KCl, Switzerland), a well-established subatmospheric pressure device, might be of interest to overcome these problems because of its ability to conform to almost any surface. The goal of this study was to test whether negative pressure application yields reliable fixation of Integra in children undergoing reconstructive surgery.
   Methods: Between 2001 and 2004, VAC was applied in 18 children (n = 18) aged 7 months to 16.5 years. All required reconstructive surgery with implantation of Integra covering 1% to 12% of the total body surface area. After Integra implantation, VAC was installed for 13 to 30 days.
   Results: The VAC fixation of Integra was successful in 17 patients (94.5%). The only failure (5.5%) occurred in a patient in whom negative pressure could not be maintained because of a lesion site susceptible to both dislodgement and infection (perianal region). Consequently, infection occurred, and Integra had to be removed.
   Conclusions: These results demonstrate that VAC is a valid tool for reliable fixation of Integra in children undergoing even demanding reconstructive surgery. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Stiefel, Dorothea; Schiestl, Clemens M.; Meuli, Martin] Univ Childrens Hosp Zurich, Dept Surg, Pediat Burn Ctr Plast & Reconstruct Surg, CH-8032 Zurich, Switzerland.
C3 University Children's Hospital Zurich
RP Stiefel, D (通讯作者)，Univ Childrens Hosp Zurich, Dept Surg, Pediat Burn Ctr Plast & Reconstruct Surg, CH-8032 Zurich, Switzerland.
EM stiefel_d@yahoo.co.uk
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   BURKE JF, 1981, ANN SURG, V194, P413, DOI 10.1097/00000658-198110000-00005
   Dantzer E, 2001, BRIT J PLAST SURG, V54, P659, DOI 10.1054/bjps.2001.3684
   HEIMBACH D, 1988, ANN SURG, V208, P313, DOI 10.1097/00000658-198809000-00008
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   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   McEwan W, 2004, BURNS, V30, P259, DOI 10.1016/j.burns.2003.11.011
   Moiemen NS, 2006, PLAST RECONSTR SURG, V117, p160S, DOI 10.1097/01.prs.0000222609.40461.68
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   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
NR 12
TC 47
Z9 52
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD MAR
PY 2009
VL 44
IS 3
BP 575
EP 580
DI 10.1016/j.jpedsurg.2008.07.006
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 426UN
UT WOS:000264733600018
PM 19302862
DA 2026-07-24
ER
PT J
AU Kollrack, Y
   Möllenhoff, G
AF Kollrack, Y.
   Moellenhoff, G.
TI Ankle osteosynthesis infection
SO UNFALLCHIRURG
LA German
DT Article
DE Infection; Osteosynthesis; Angiopathy; Ankle fracture; Vacuum therapy
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; FRACTURES;
   COMPLICATIONS
AB Should osteosynthesis infection occur after ankle fractures in patients with microangiopathy, the infection needs to be cured quickly and safely to protect implants, bone, and tendons. Vacuum therapy (TNP) provides a perfect treatment plan that keeps the inpatient time low whilst ensuring high patient comfort.
   Four angiopathic patients with deep wound infection after ankle osteosynthesis were treated. At admission, loss of stability and spread of the infection were the immeadiate risks. To prevent this, we treated the patients with vacuum therapy after initial debridement until skin cover was achieved.
   In all cases stability was secured and after 2 dressing changes, the swabs were sterile. The inpatient time was 13 days; overall vacuum therapy time was 59 days. Patient satisfaction was high.
   Vacuum therapy is a perfect strategy after surgical debridement and before secondary mesh grafting. It protects the stability of the bone and open-lying delicate structures in patients with infected osteosynthesis of the ankle and angiopathy and offers an easy, safe, and successful treatment path with a short inpatient time.
C1 [Kollrack, Y.; Moellenhoff, G.] Raphaelsklin Munster, Abt Unfall & Wiederherstellungschirurg, D-48143 Munster, Germany.
RP Kollrack, Y (通讯作者)，Raphaelsklin Munster, Abt Unfall & Wiederherstellungschirurg, Loerstr 23, D-48143 Munster, Germany.
EM ykollrack@yahoo.de
CR Anagnostakos K, 2006, ZBL CHIR, V131, pS87, DOI 10.1055/s-2006-921514
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   BECKER R, 2006, ZENTRALBL CHIR, V131, P93
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   *KCI MED PROD, KCI DEUTSCHL PROD
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   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
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   REICHERT B, 2006, ZENTRALBL CHIR, V131, P24
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NR 31
TC 4
Z9 5
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD APR
PY 2009
VL 112
IS 4
BP 433
EP 438
DI 10.1007/s00113-008-1521-x
PG 6
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 428WY
UT WOS:000264884000013
PM 19283356
DA 2026-07-24
ER
PT J
AU van Hensbroek, PB
   Wind, J
   Dijkgraaf, MGW
   Busch, ORC
   Goslings, JC
AF van Hensbroek, Pieter Boele
   Wind, Jan
   Dijkgraaf, Marcel G. W.
   Busch, Olivier R. C.
   Goslings, J. Carel
TI Temporary Closure of the Open Abdomen: A Systematic Review on Delayed
   Primary Fascial Closure in Patients with an Open Abdomen
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; DAMAGE CONTROL
   LAPAROTOMY; PACK TECHNIQUE; WOUND CLOSURE; WALL RECONSTRUCTION; OPEN
   MANAGEMENT; TRAUMA PATIENTS; VENTRAL HERNIA; MARLEX MESH
AB Background This study was designed to systematically review the literature to assess which temporary abdominal closure (TAC) technique is associated with the highest delayed primary fascial closure (FC) rate. In some cases of abdominal trauma or infection, edema or packing precludes fascial closure after laparotomy. This "open abdomen'' must then be temporarily closed. However, the FC rate varies between techniques.
   Methods The Cochrane Register of Controlled Trials, MEDLINE, and EMBASE databases were searched until December 2007. References were checked for additional studies. Search criteria included (synonyms of) "open abdomen,'' "fascial closure,'' "vacuum,'' "reapproximation,'' and "ventral hernia.'' Open abdomen was defined as "the inability to close the abdominal fascia after laparotomy.'' Two reviewers independently extracted data from original articles by using a predefined checklist.
   Results The search identified 154 abstracts of which 96 were considered relevant. No comparative studies were identified. After reading them, 51 articles, including 57 case series were included. The techniques described were vacuum-assisted closure (VAC; 8 series), vacuum pack (15 series), artificial burr (4 series), Mesh/sheet (16 series), zipper (7 series), silo (3 series), skin closure (2 series), dynamic retention sutures (DRS), and loose packing (1 series each). The highest FC rates were seen in the artificial burr (90%), DRS (85%), and VAC (60%). The lowest mortality rates were seen in the artificial burr (17%), VAC (18%), and DRS (23%).
   Conclusions These results suggest that the artificial burr and the VAC are associated with the highest FC rates and the lowest mortality rates.
C1 [van Hensbroek, Pieter Boele; Wind, Jan; Busch, Olivier R. C.; Goslings, J. Carel] Acad Med Ctr, Dept Surg, NL-1100 DD Amsterdam, Netherlands.
   [Dijkgraaf, Marcel G. W.] Acad Med Ctr, Dept Clin Epidemiol & Biostat, NL-1100 DD Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam
RP van Hensbroek, PB (通讯作者)，Acad Med Ctr, Dept Surg, POB 22660,Room G4-150, NL-1100 DD Amsterdam, Netherlands.
EM p.boelevanhensbroek@amc.uva.nl
RI Dijkgraaf, Marcel/G-6663-2011; Busch, Olivier/AAC-3650-2020
FU Siemens Netherlands; ZonMw [945-06-901]
FX P. Boele van Hensbroek was supported by an unrestricted grant from
   Siemens Netherlands N. V., and J. Wind was supported by a grant
   (945-06-901) from ZonMw.
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NR 56
TC 236
Z9 255
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD FEB
PY 2009
VL 33
IS 2
BP 199
EP 207
DI 10.1007/s00268-008-9867-3
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 430OF
UT WOS:000264997700006
PM 19089494
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Wilkes, R
   Zhao, Y
   Cunningham, K
   Kieswetter, K
   Haridas, B
AF Wilkes, R.
   Zhao, Y.
   Cunningham, K.
   Kieswetter, K.
   Haridas, B.
TI 3D strain measurement in soft tissue: Demonstration of a novel inverse
   finite element model algorithm on MicroCT images of a tissue phantom
   exposed to negative pressure wound therapy
SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CELL-SHAPE; ENDOTHELIAL-CELLS;
   RANDOMIZED-TRIAL; GROWTH-CONTROL; BLOOD-FLOW; ANGIOGENESIS;
   DEFORMATIONS; TENSION; ULCERS
AB This study describes a novel system for acquiring the 3D strain field in soft tissue at sub-millimeter spatial resolution during negative pressure wound therapy (NPWT). Recent research in advanced wound treatment modalities theorizes that microdeformations induced by the application of sub-atmospheric (negative) pressure through V.A.C.(R) GranuFoam (R) Dressing, a reticulated open-cell polyurethane foam (ROCF), is instrumental in regulating the mechanobiology of granulation tissue formation [Saxena, V., Hwang, CW., Huang, S., Eichbaum, Q., Ingber, D., Orgill, D.P., 2004. Vacuum-assisted closure: Microdeformations of wounds and cell proliferation. Plast. Reconstr. Surg. 114, 1086-1096]. While the clinical response is unequivocal, measurement of deformations at the wound-dressing interface has not been possible due to the inaccessibility of the wound tissue beneath the sealed dressing. Here we describe the development of a bench-test wound model for microcomputed tomography (microCT) imaging of deformation induced by NPWT and an algorithm set for quantifying the 3D strain field at sub-millimeter resolution. Microdeformations induced in the tissue phantom revealed average tensile strains of 18%-23% at sub-atmospheric pressures of -50 to -200 mmHg (-6.7 to -26.7 kPa). The compressive strains (22%-24%) and shear strains (20%-23%) correlate with 2D FEM studies of microdeformational wound therapy in the reference cited above. We anticipate that strain signals quantified using this system can then be used in future research aimed at correlating the effects of mechanical loading on the phenotypic expression of dermal fibroblasts in acute and chronic ulcer models. Furthermore, the method developed here can be applied to continuum deformation analysis in other contexts, such as 3D cell culture via confocal microscopy, full scale CT and MRI imaging, and in machine vision. (c) 2008 Elsevier Ltd. All rights reserved.
C1 [Wilkes, R.] Kinet Concepts Inc, Global Res, Adv Mat Grp, San Antonio, TX 78249 USA.
   [Cunningham, K.; Haridas, B.] Device & Implant Innovat LLC, Mason, OH 45040 USA.
   [Haridas, B.] Univ Cincinnati, Dept Biomed Engn, Cincinnati, OH 45221 USA.
C3 University System of Ohio; University of Cincinnati
RP Wilkes, R (通讯作者)，Kinet Concepts Inc, Global Res, Adv Mat Grp, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM rob.wilkes@kcil.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Gold S, 1998, PATTERN RECOGN, V31, P1019, DOI 10.1016/S0031-3203(98)80010-1
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   Holzapfel G.A., 2006, MECH BIOL TISSUE
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   Ingber D.E., 1989, Cell Shape: Determinants Regulation and Regulatory Role, P3
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   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
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NR 41
TC 26
Z9 30
U1 0
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1751-6161
EI 1878-0180
J9 J MECH BEHAV BIOMED
JI J. Mech. Behav. Biomed. Mater.
PD JUL
PY 2009
VL 2
IS 3
BP 272
EP 287
DI 10.1016/j.jmbbm.2008.10.006
PG 16
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 430SO
UT WOS:000265009000007
PM 19627832
DA 2026-07-24
ER
PT J
AU Benninger, E
   Laschke, MW
   Cardell, M
   Keel, M
   Seifert, B
   Trentz, O
   Menger, MD
   Meier, C
AF Benninger, Emanuel
   Laschke, Matthias W.
   Cardell, Markus
   Keel, Marius
   Seifert, Burkhardt
   Trentz, Otmar
   Menger, Michael D.
   Meier, Christoph
TI Intra-Abdominal Pressure Development After Different Temporary Abdominal
   Closure Techniques in a Porcine Model
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Temporary abdominal closure; Intra-abdominal pressure; Abdominal
   compartment syndrome; Animal model; Abdominal injuries; Intra-abdominal
   hypertension
ID COMPARTMENT SYNDROME; OPEN ABDOMEN; FASCIAL CLOSURE; SILO CLOSURE;
   TRAUMA; HYPERTENSION; WOUNDS
AB Background: Decompressive laparotomy followed by temporary abdominal closure (TAC) is an established prophylaxis and treatment for abdominal compartment syndrome. The herein presented study aimed at the comparison of volume reserve capacity and development of intra-abdominal hypertension after forced primary abdominal closure and different TAC techniques in a porcine model.
   Methods: Eight anesthesized and mechanically ventilated domestic pigs underwent a standardized midline laparotomy. A bag was placed into the abdominal cavity. Before abdominal closure, the bag was prefilled with 3,000 mL water to simulate increased intra-abdominal volume. The intra-abdominal pressure (IAP) was then increased in 2 mm Hg steps up to 30 turn Hg by adding volume (volume reserve capacity) to the intra-abdominal bag. Volume reserve capacity with the corresponding IAP were analyzed and compared for primary abdominal closure, bag silo closure, a zipper system, and vacuum-assisted closure (VAC) with different negative pressures (-50, -100, and -150 mm Hg). Hemodynamic and pulmonary parameters were monitored throughout the experiment.
   Results: Volume reserve capacity was the highest for bag silo closure followed by the zipper system and VAC with primary abdominal closure providing the least volume reserve capacity in the whole LAP range. Of interest, VAC -50 nun Hg resulted in a lower volume reserve capacity when compared with VAC -100 and -150 mm Hg. Pulmonary and hemodynamic parameters demonstrated no significant differences between primary abdominal closure and the evaluated TAC techniques at all IAP levels.
   Conclusions: The present experimental in vivo study indicates that bag silo closure and zipper systems may be favorable TAC techniques after decompressive laparotomy. In contrast, the VAC techniques resulted in lower volume reserve capacity and therefore may bear an increased risk for recurrent intra-abdominal hypertension in the initial phase after decompressive laparotomy.
C1 [Benninger, Emanuel; Cardell, Markus; Keel, Marius; Trentz, Otmar; Meier, Christoph] Univ Zurich Hosp, Div Trauma Surg, CH-8091 Zurich, Switzerland.
   [Laschke, Matthias W.; Menger, Michael D.] Univ Saarland, Inst Clin & Expt Surg, D-6600 Saarbrucken, Germany.
   [Seifert, Burkhardt] Univ Zurich, ISPM, Biostat Unit, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; Saarland University;
   University of Zurich
RP Meier, C (通讯作者)，Univ Zurich Hosp, Div Trauma Surg, Raemistr 100, CH-8091 Zurich, Switzerland.
EM christoph.meier@usz.ch
OI Seifert, Burkhardt/0000-0002-5829-2478; Laschke, Matthias
   W/0000-0002-7847-8456
CR [Anonymous], SPSS COMP PROGR VERS
   [Anonymous], EUR J TRAUMA
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NR 24
TC 17
Z9 18
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD APR
PY 2009
VL 66
IS 4
BP 1118
EP 1124
DI 10.1097/TA.0b013e3181820d94
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 431KI
UT WOS:000265059800029
PM 19359923
OA Green Accepted
DA 2026-07-24
ER
PT J
AU Wilkes, R
   Zhao, Y
   Kieswetter, K
   Haridas, B
AF Wilkes, R.
   Zhao, Y.
   Kieswetter, K.
   Haridas, B.
TI Effects of Dressing Type on 3D Tissue Microdeformations During Negative
   Pressure Wound Therapy: A Computational Study
SO JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
LA English
DT Article
DE biology computing; biomechanics; cellular biophysics; computerised
   tomography; deformation; finite element analysis; patient treatment;
   polymer foams; skin; wounds
ID VACUUM-ASSISTED CLOSURE; CELL-SHAPE; ENDOTHELIAL-CELLS;
   RANDOMIZED-TRIAL; GROWTH-CONTROL; BLOOD-FLOW; ANGIOGENESIS; MATRIX;
   PROLIFERATION; TENSION
AB Vacuum-assisted closure (R) (VAC (R)) therapy, also referred to as vacuum-assisted closure (R) negative pressure wound therapy (VAC (R) NPWT), delivered to various dermal wounds is believed to influence the formation of granulation tissue via the mechanism of microdeformational signals. In recent years, numerous experimental investigations have been initiated to study the cause-effect relationships between the mechanical signals and the transduction pathways that result in improved granulation response. To accurately quantify the tissue microdeformations during therapy, a new three-dimensional finite element model has been developed and is described in this paper. This model is used to study the effect of dressing type and subatmospheric pressure level on the variations in the microdeformational strain fields in a model dermal wound bed. Three-dimensional geometric models representing typical control volumes of NPWT dressings were generated using micro-CT scanning of VAC (R) GranuFoam (R), a reticulated open-cell polyurethane foam (ROCF), and a gauze dressing (constructed from USP Class VII gauze). Using a nonlinear hyperfoam constitutive model for the wound bed, simulated tissue microdeformations were generated using the foam and gauze dressing models at equivalent negative pressures. The model results showed that foam produces significantly greater strain than gauze in the tissue model at all pressures and in all metrics (p < 0.0001 for all but epsilon(vol) at -50 mm Hg and -100 mm Hg where p < 0.05). Specifically, it was demonstrated in this current work that the ROCF dressing produces higher levels of tissue microdeformation than gauze at all levels of subatmospheric pressure. This observation is consistent across all of the strain invariants assessed, i.e., epsilon(vol), epsilon(dist), the minimum and maximum principal strains, and the maximum shear strain. The distribution of the microdeformations and strain appears as a repeating mosaic beneath the foam dressing, whereas the gauze dressings appear to produce an irregular distribution of strains in the wound surface. Strain predictions from the developed computational model results agree well with those predicted from prior two-dimensional experimental and computational studies of foam-based NPWT (Saxena, V., , 2004, "Vacuum-assisted closure: Microdeformations of Wounds and Cell Proliferation," Plast. Reconstr. Surg., 114(5), pp. 1086-1096). In conjunction with experimental in vitro and in vivo studies, the developed model can now be extended into more detailed investigations into the mechanobiological underpinnings of VAC (R) NPWT and can help to further develop and optimize this treatment modality for the treatment of challenging patient wounds.
C1 [Wilkes, R.; Zhao, Y.; Kieswetter, K.] Kinet Concepts Inc, San Antonio, TX 78249 USA.
   [Haridas, B.] Univ Cincinnati, Dept Biomed Engn, Cincinnati, OH 45221 USA.
   [Haridas, B.] Device & Implant Innovat LLC, Mason, OH 45040 USA.
C3 University System of Ohio; University of Cincinnati
RP Wilkes, R (通讯作者)，Kinet Concepts Inc, San Antonio, TX 78249 USA.
EM rob.wilkes@kci1.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ARGENTA LC, 1990, TISSUE EXPANSION, P103
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Chen CS, 1997, SCIENCE, V276, P1425, DOI 10.1126/science.276.5317.1425
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   *EPAPS, EJBENDY130011804 EPA
   FOLKMAN J, 1978, NATURE, V273, P345, DOI 10.1038/273345a0
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   *US PHARM, 2004, MON US PHARM, P856
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
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NR 48
TC 45
Z9 59
U1 0
U2 16
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0148-0731
EI 1528-8951
J9 J BIOMECH ENG-T ASME
JI J. Biomech. Eng.-Trans. ASME
PD MAR
PY 2009
VL 131
IS 3
AR 031012
DI 10.1115/1.2947358
PG 12
WC Biophysics; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Engineering
GA 432MG
UT WOS:000265137800012
PM 19154071
DA 2026-07-24
ER
PT J
AU Sari, A
   Fesli, A
   Yener, T
   Basterzi, Y
   Demirkan, F
AF Sari, Alper
   Fesli, Atilla
   Yener, Tolga
   Basterzi, Yavuz
   Demirkan, Ferit
TI The Efficacy of Topical Negative Pressure in the Management of Infected
   and Non-infected Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; THERAPY; FOUNDATION; TRIAL; STATE
AB This study evaluates the efficacy of a vacuum-assisted closure (V.A.C.(R) Therapy, KCl, San Antonio, Tex) device in the comparative management of clean and infected wounds. Vacuum-assisted closure was applied to 57 wounds of 51 patients. Methods. Our protocol consisted of debridement of all necrotic tissue followed by vacuum-assisted closure therapy along with appropriate antibiotic administration. In 5 cases with peripheral circulation impairment, vacuum-assisted closure therapy was terminated due to a poor tissue response. In the remaining 52 wounds, healthy granulation tissue generation was observed. Wound cultures obtained from these patients prior to the start of vacuum-assisted closure proved the presence of infection. Results. The average sizes of the infected and non-infected wounds were 55.77 cm(2) and 57.94 cm(2) prior to the start of vacuum-assisted closure, respectively, while they were reduced to 48.28 cm(2) and 45.70 cm(2) after the last session. At the conclusion of vacuum-assisted closure therapy, 42 wounds were skin grafted and 10 wounds were covered with skin/muscle flaps. Conclusion. Vacuum-assisted closure therapy is a reliable tool in the management of almost any type of wound, whether infected or not infected, unless major circulatory impairment interferes and acted as a contributary factor in wound formation.
C1 [Sari, Alper; Fesli, Atilla; Yener, Tolga; Basterzi, Yavuz; Demirkan, Ferit] Mersin Univ, Dept Plast & Reconstruct Surg, Mersin, Turkey.
C3 Mersin University
RP Sari, A (通讯作者)，Mersin Univ, Kampusu 33343, Mezitli Mersin, Turkey.
EM dralpersari@yahoo.com
RI /G-5030-2015
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 16
TC 1
Z9 1
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2009
VL 21
IS 4
BP 95
EP 101
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 435QD
UT WOS:000265357500004
PM 25903231
DA 2026-07-24
ER
PT J
AU Subramonia, S
   Pankhurst, S
   Rowlands, BJ
   Lobo, DN
AF Subramonia, Sriram
   Pankhurst, Sarah
   Rowlands, Brian J.
   Lobo, Dileep N.
TI Vacuum-Assisted Closure of Postoperative Abdominal Wounds: A Prospective
   Study
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID PLANNED VENTRAL HERNIA; ENTEROCUTANEOUS FISTULA; FASCIAL CLOSURE;
   COMPARTMENT SYNDROME; TEMPORARY CLOSURE; WALL; MANAGEMENT; EXPERIENCE;
   TRAUMA
AB We aimed to study outcome in patients with an open abdomen in whom the abdominal vacuum-assisted closure system (V.A.C.(A (R)) Therapy((TM))) was used to provide temporary cover and achieve wound closure.
   All patients in whom V.A.C. Therapy was used to manage laparotomy wounds between February 2006 and May 2007 at a University Teaching Hospital were followed up prospectively until successful completion or stoppage of V.A.C. Therapy.
   Of the 51 consecutive patients (33 male), V.A.C. Therapy was used to manage a laparostomy in 10 patients and abdominal wound dehiscence in 41. Median (IQR) duration of V.A.C. Therapy was 17 (7-26) days. Wound healing was achieved in 31 (61%) patients, four of whom had additional surgery to assist wound closure. The rest healed by secondary intention. Treatment was withdrawn due to therapy-related complications in nine patients and due to medical or logistical reasons in seven. Four patients died while on therapy. While most V.A.C. Therapy-related problems were minor, two patients developed enteric fistulae that necessitated surgical repair. At a median (IQR) follow-up of 8 (4-13) months, 18 patients had stable cutaneous coverage with no incisional hernia, 12 developed an incisional hernia, 9 were lost to follow-up, and 12 died.
   V.A.C. Therapy is a useful adjunct in the management of the open abdomen and should be considered in the treatment of this problem. Restoration of cutaneous and fascial integrity of the abdominal wall, the risk of fistulisation, and the cost-effectiveness of this therapy require further evaluation.
C1 [Subramonia, Sriram; Rowlands, Brian J.; Lobo, Dileep N.] Univ Nottingham Hosp, Div Gastrointestinal Surg, Nottingham Digest Dis Ctr, Res Unit,Queens Med Ctr, Nottingham NG7 2UH, England.
   [Pankhurst, Sarah] Nottingham City Primary Care Trust, Sherwood Hlth Ctr, Tissue Viabil Serv, Nottingham NG5 4AD, England.
C3 University of Nottingham
RP Lobo, DN (通讯作者)，Univ Nottingham Hosp, Div Gastrointestinal Surg, Nottingham Digest Dis Ctr, Res Unit,Queens Med Ctr, Nottingham NG7 2UH, England.
EM Dileep.Lobo@nottingham.ac.uk
RI Lobo, Dileep N/AAC-6207-2020
OI Lobo, Dileep N/0000-0003-1187-5796
CR AKERS DL, 1991, J VASC SURG, V14, P48
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NR 29
TC 46
Z9 55
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD MAY
PY 2009
VL 33
IS 5
BP 931
EP 937
DI 10.1007/s00268-009-9947-z
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 436BH
UT WOS:000265387100006
PM 19234864
DA 2026-07-24
ER
PT J
AU Koh, C
   Sugo, E
   Wargon, O
AF Koh, Clare
   Sugo, Ella
   Wargon, Orli
TI Unusual presentation of GLUT-1 positive infantile haemangioma
SO AUSTRALASIAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE Infantile haemangioma; congenital haemangioma; reticular haemangioma of
   infancy; glucose transporter protein 1 (GLUT-1); Vacuum Assisted Closure
   (VAC) therapy
ID INVOLUTING CONGENITAL HEMANGIOMAS; VACUUM-ASSISTED CLOSURE; SUBTYPES
AB Infantile haemangiomas are usually not present at birth. This is a case of a female infant with an atypical congenital vascular tumour present at birth which ulcerated in the first few days of life, involuted over several months and showed histopathological features in keeping with either an involuting GLUT-1 positive infantile haemangioma or a reticular haemangioma of infancy. The initial clinical presentation was atypical for an infantile haemangiomas and for a congenital haemangioma, however the histopathology and immunohistochemistry assisted with confirmation of the diagnosis. Vacuum-assisted closure (VAC) therapy aided in the complete healing of the ulcerated infantile haemangioma which was not achievable with conventional dressings.
C1 [Wargon, Orli] Sydney Childrens Hosp, Dept Paediat Dermatol, Vasc Birthmark Clin, Randwick, NSW 2031, Australia.
   [Sugo, Ella] Prince Wales Hosp, Dept Anat Pathol, S Eastern Area Lab Serv, Sydney, NSW, Australia.
C3 NSW Health; Sydney Childrens Hospitals Network; University of New South
   Wales Sydney; Prince of Wales Hospital (POWH)
RP Wargon, O (通讯作者)，Sydney Childrens Hosp, Dept Paediat Dermatol, Vasc Birthmark Clin, High St, Randwick, NSW 2031, Australia.
EM owargon@bigpond.net.au
RI Wargon, Orli/D-6204-2015
OI Wargon, Orli/0000-0002-4466-6985
CR Ahrens WA, 2008, HUM PATHOL, V39, P1519, DOI 10.1016/j.humpath.2008.03.002
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Atherton DJ, 2004, ROOKS TXB DERMATOLOG
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NR 24
TC 4
Z9 5
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0004-8380
EI 1440-0960
J9 AUSTRALAS J DERMATOL
JI Australas. J. Dermatol.
PD MAY
PY 2009
VL 50
IS 2
BP 136
EP 140
DI 10.1111/j.1440-0960.2009.00527.x
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 437IL
UT WOS:000265480400011
PM 19397570
DA 2026-07-24
ER
PT J
AU Kairinos, N
   Solomons, M
   Hudson, DA
AF Kairinos, Nicolas
   Solomons, Michael
   Hudson, Donald A.
TI Negative-Pressure Wound Therapy I: The Paradox of Negative-Pressure
   Wound Therapy
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 52nd Annual Congress of the
   Association-of-Plastic-and-Reconstructive-Surgeons-of-Southern-Africa
CY OCT 19-22, 2008
CL Sun City, SOUTH AFRICA
SP Assoc Plast & Reconstruct Surg S Africa
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; BLOOD-FLOW
AB Background: Does negative-pressure wound therapy reduce or increase the pressure of wound tissues? This seemingly obvious question has never been addressed by a study on living tissues. The aim of this study was to evaluate the nature of tissue pressure changes in relation to negative-pressure wound therapy.
   Methods: Three negative-pressure wound therapy dressing configurations were evaluated-circumferential, noncircumferential, and those within a cavity-on 15 human wounds, with five wounds in each category. Tissue pressure changes were recorded (using a strain gauge sensor) for each 75-mmHg increment in suction, up to -450 mmHg. In the circumferential and noncircumferential groups, tissue pressure was also measured over a 48-hour period at a set suction pressure of -125 mmHg (n = 10).
   Results: In all three groups, mean tissue pressure increased proportionately to the amount of suction applied (p < 0.0005). Mean tissue pressure increments resulting from the circumferential dressings were significantly higher than those resulting from the noncircumferential (p < 0.0005) or cavity group (p < 0.0005); however, there was no significant difference between the latter two groups (p < 0.269). Over the 48-hour period, there was a significant mean reduction in the (increased) tissue pressure (p < 0.04 for circumferential and p < 0.0005 for noncircumferential), but in only three of 10 cases did this reduce to pressures less than those before dressing application.
   Conclusions: Negative-pressure wound therapy increases tissue pressure proportionately to the amount of suction, although this becomes less pronounced over 48 hours. This suggests that negative-pressure wound therapy dressings should be used with caution on tissues with compromised perfusion, particularly when they are circumferential. (Plast. Reconstr. Surg. 123: 589, 2009.)
C1 Groote Schuur Hosp, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
   Groote Schuur Hosp, Martin Singer Hand Unit, Dept Orthopaed Surg, ZA-7925 Cape Town, South Africa.
   Univ Cape Town, ZA-7925 Cape Town, South Africa.
C3 University of Cape Town; University of Cape Town; University of Cape
   Town
RP Kairinos, N (通讯作者)，Groote Schuur Hosp, Dept Plast Surg, H53,Old Main Bldg,Main Rd, ZA-7925 Cape Town, South Africa.
EM nickykairinos@gmail.com
CR ANDROS G, 2006, OSTOMY WOUND MANAG S, V1
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Breen E, 2008, HIGH ALT MED BIOL, V9, P158, DOI 10.1089/ham.2008.1010
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   Petzina R, 2006, EUR J CARDIO-THORAC, V30, P85, DOI 10.1016/j.ejcts.2006.04.009
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
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   2005, HOME HEALTHC NURSE, V23, P469
NR 19
TC 132
Z9 144
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD FEB
PY 2009
VL 123
IS 2
BP 589
EP 598
DI 10.1097/PRS.0b013e3181956551
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 440AE
UT WOS:000265669200019
PM 19182617
DA 2026-07-24
ER
PT J
AU Kairinos, N
   Voogd, AM
   Botha, PH
   Kotze, T
   Kahn, D
   Hudson, DA
   Solomons, M
AF Kairinos, Nicolas
   Voogd, Anda M.
   Botha, Pieter H.
   Kotze, Tessa
   Kahn, Delawir
   Hudson, Donald A.
   Solomons, Michael
TI Negative-Pressure Wound Therapy II: Negative-Pressure Wound Therapy and
   Increased Perfusion. Just an Illusion?
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 52nd Annual Congress of the
   Association-of-Plastic-and-Reconstructive-Surgeons-of-Southern-Africa
CY OCT 19-22, 2008
CL Sun City, SOUTH AFRICA
SP Assoc Plast & Reconstruct Surg So Africa
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; BLOOD-FLOW
AB Background: A recent study demonstrated that negative-pressure wound therapy increases underlying tissue pressure. This finding is incongruous with studies using laser Doppler that show that perfusion is immediately increased on initiation of suction. This study investigated perfusion in negative-pressure wound therapy using two alternative modalities.
   Methods: Radioisotope perfusion imaging was used to determine perfusion beneath circumferential negative-pressure wound therapy dressings on 20 healthy hands (n = 20). Ten hands received suction pressures of -400 mmHg and 10 received -125 mmHg, with the contralateral hand used as a control without any suction. Transcutaneous partial pressure of oxygen was used to determine perfusion beneath noncircumferential negative-pressure wound therapy dressings on 12 healthy legs (n = 12), with each volunteer being sequentially randomized to receive suction pressures of -400 and -125 mmHg, respectively.
   Results: Tissues undergoing circumferential negative-pressure wound therapy demonstrated a mean reduction in perfusion of 40 +/- 11.5 percent (p < 0.0005) and 17 +/- 8.9 percent (p < 0.0005) at suction pressures of -400 mmHg and -125 mmHg, respectively. Perfusion reduction at -400 mmHg was significantly greater than at -125 mmHg (p < 0.015). In the noncircumferential negative-pressure wound therapy group, there was a mean reduction in transcutaneous partial pressure of oxygen of 7.35 +/- 7.4 mmHg (p < 0.0005) and 5.10 +/- 7.4 mmHg(p < 0.0005) at suction pressures of -400 mmHg and -125 mmHg, respectively. There was a tendency for greater reductions in the -400 mmHg group, but this was not significantly different from the -125 mmHg group (p = 0.07).
   Conclusions: These findings demonstrate that perfusion beneath negative-pressure wound therapy decreases for increasing suction pressure. Thus, it is suggested that negative-pressure wound therapy should be used with caution on tissues with compromised vascularity, particularly when used circumferentially. (Plast. Reconstr. Surg. 123: 601, 2009.)
C1 [Kairinos, Nicolas] Groote Schuur Hosp, Dept Plast Surg, ZA-7925 Cape Town, South Africa.
   Groote Schuur Hosp, Dept Nucl Med, ZA-7925 Cape Town, South Africa.
   Groote Schuur Hosp, Dept Surg, ZA-7925 Cape Town, South Africa.
   Groote Schuur Hosp, Dept Orthopaed Surg, ZA-7925 Cape Town, South Africa.
C3 University of Cape Town; University of Cape Town; University of Cape
   Town; University of Cape Town
RP Kairinos, N (通讯作者)，Groote Schuur Hosp, Dept Plast Surg, H53,Old Main Bldg,Main Rd, ZA-7925 Cape Town, South Africa.
EM nickykairinos@gmail.com
RI /T-4458-2019
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Attinger CE, 2006, PLAST RECONSTR SURG, V117, p72S, DOI 10.1097/01.prs.0000225470.42514.8f
   BANWELL P, 2005, THERAPY CLIN GUIDELI
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
   Miller MS, 2005, OSTOMY WOUND MANAG, V51, P44
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Petzina R, 2006, EUR J CARDIO-THORAC, V30, P85, DOI 10.1016/j.ejcts.2006.04.009
   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   Ullmann Y, 2006, ANN PLAS SURG, V56, P401, DOI 10.1097/01.sap.0000201552.81612.68
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
   Willy C, 2006, ZBL CHIR, V131, pS50, DOI 10.1055/s-2006-921421
NR 15
TC 145
Z9 159
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD FEB
PY 2009
VL 123
IS 2
BP 601
EP 612
DI 10.1097/PRS.0b013e318196b97b
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 440AE
UT WOS:000265669200021
PM 19182619
DA 2026-07-24
ER
PT J
AU Ozturk, E
   Ozguc, H
   Yilmazlar, T
AF Ozturk, Ersin
   Ozguc, Halil
   Yilmazlar, Tuncay
TI The use of vacuum assisted closure therapy in the management of
   Fournier's gangrene
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Fournier's gangrene; VAC therapy; Negative pressure vacuuming; Wound
   care
ID NEGATIVE-PRESSURE THERAPY; WOUND CONTROL; SKIN-GRAFTS; RECONSTRUCTION;
   DEVICE; ULCERS; FLORA
AB BACKGROUND: Vacuum Assisted Closure (VAC; Kinetic Concepts, Inc., San Antonio, TX) has been Used to successfully treat a variety of complex Wounds. This technique was investigated for use in managing Fournier's gangrene following initial debridement.
   METHODS: Ten patients with Fournier's gangrene were treated in this study. After initial surgical debridement, 5 were treated using conventional therapy and 5 were treated with VAC at each dressing change. The effectiveness and cost of VAC for this indication were assessed: patient and physician satisfaction were also determined.
   RESULTS: Conventional and VAC treatment were equally effective in healing the wounds. The total costs of each treatment were similar. With the use of VAC, patients had fewer dressing changes, less pain, fewer skipped meals, and greater mobility, Hands-on treatment time was decreased for physicians using VAC.
   CONCLUSIONS: VAC therapy is an effective and economical way to manage Fournier's gangrene. Patients and physicians were more satisfied with VAC therapy than with conventional treatment. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Ozturk, Ersin; Ozguc, Halil; Yilmazlar, Tuncay] Uludag Univ, Fac Med, Dept Gen Surg 16069, Gorukle, Bursa, Turkey.
C3 Uludag University
RP Ozturk, E (通讯作者)，Uludag Univ, Fac Med, Dept Gen Surg 16069, Gorukle, Bursa, Turkey.
EM drozturk@uludag.edu.tr
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Chester DL, 2002, BRIT J PLAST SURG, V55, P510, DOI 10.1054/bjps.2002.3890
   Conquest AM, 2003, J SURG RES, V115, P209, DOI 10.1016/S0022-4804(03)00331-7
   Demaria RG, 2003, J CARDIOVASC SURG, V44, P757
   Eke N, 2000, BJS-BRIT J SURG, V87, P718, DOI 10.1046/j.1365-2168.2000.01497.x
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   Kercher Kent W, 2002, Ostomy Wound Manage, V48, P40
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
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   Senchenkov A, 2006, UROLOGY, V67, P416, DOI 10.1016/j.urology.2005.08.037
   SKILLMAN J, 2003, ORBIT, V22, P62
   Sposato G, 2001, BRIT J PLAST SURG, V54, P235, DOI 10.1054/bjps.2000.3537
   Teenier Pamela, 2007, Home Healthc Nurse, V25, P470, DOI 10.1097/01.NHH.0000281614.96670.80
   Weinfeld AB, 2005, ANN PLAS SURG, V54, P178, DOI 10.1097/01.sap.0000143606.39693.3f
   Yilmazlar T, 2007, WORLD J SURG, V31, P1858, DOI 10.1007/s00268-007-9132-1
NR 27
TC 79
Z9 95
U1 0
U2 7
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2009
VL 197
IS 5
BP 660
EP 665
DI 10.1016/j.amjsurg.2008.04.018
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 442SB
UT WOS:000265859800023
PM 18789410
DA 2026-07-24
ER
PT J
AU Chariker, ME
   Gerstle, TL
   Morrison, CS
AF Chariker, Mark E.
   Gerstle, Theodore L.
   Morrison, Clinton S.
TI An Algorithmic Approach to the Use of Gauze-Based Negative-Pressure
   Wound Therapy as a Bridge to Closure in Pediatric Extremity Trauma
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; TIBIAL SHAFT FRACTURES;
   TEMPORARY TREATMENT; CHILDREN; MANAGEMENT; STRESS; REPAIR; SYSTEM
AB Background: The efficacy of negative-pressure wound therapy as a bridge to definitive closure of traumatic extremity wounds has been demonstrated in adults. Gauze-based negative-pressure wound therapy has been used to facilitate granulation tissue formation and promote closure in a number of wound types. In this study, the authors evaluated the efficacy of gauze-based negative-pressure wound therapy using the Chariker-Jeter technique for pediatric extremity wounds requiring delayed closure.
   Methods: A retrospective review was conducted of 24 pediatric patients presenting with extremity injuries involving soft-tissue defects not amenable to immediate primary closure. After initial irrigation, debridement, and antibiotic therapy, negative-pressure wound therapy using the Chariker-Jeter technique was applied and dressings were changed at 48- to 72-hour intervals before secondary closure or primary closure by skin graft, local flaps, or free tissue transfer.
   Results: Granulation tissue was noted in all wounds by day 4. The duration of vacuum therapy averaged 10 days in patients whose wounds were closed primarily (n = 19) and 17 days in patients who were allowed to heal by secondary intention (n = 5). Nine patients' wounds were closed with skin grafts and local flaps, eight were closed with local flaps only, and three were closed with free tissue transfer. There was no incidence of skin graft loss or flap failure. Follow-up evaluation of the wounds averaged 24 months, during which no complications were noted.
   Conclusions: As a relatively atraumatic wound care technique with few complications, gauze-based negative-pressure wound therapy with the Chariker-Jeter technique provides a highly effective option for temporary soft-tissue management of extremity trauma in pediatric patients. (Plast. Reconstr. Surg. 123: 1510, 2009.)
C1 [Chariker, Mark E.; Gerstle, Theodore L.; Morrison, Clinton S.] Aesthet Plast Surg Inst, Louisville, KY 40202 USA.
RP Chariker, ME (通讯作者)，Aesthet Plast Surg Inst, 444 S 1st St,Suite 200, Louisville, KY 40202 USA.
EM drchariker@drchariker.com
FU Aesthetic Plastic Surgery Institute
FX This work was conducted within the Aesthetic Plastic Surgery Institute
   and was not supported by outside funding sources. Mark E. Chariker, M.
   D., is a consultant for and has received honoraria from Smith & Nephew
   and Medela. Smith & Nephew fully owns the Chariker-Jeter registered
   trademark, and the author receives no royalties or financial
   compensation for the use of the Chariker-Jeter technique. Neither of the
   other authors has any additional financial information to disclose.
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NR 25
TC 34
Z9 44
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAY
PY 2009
VL 123
IS 5
BP 1510
EP 1520
DI 10.1097/PRS.0b013e3181a20563
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 445QZ
UT WOS:000266067900016
PM 19407624
DA 2026-07-24
ER
PT J
AU Spychala, A
   Murawa, D
   Nowaczyk, P
   Polom, K
AF Spychala, Arkadiusz
   Murawa, Dawid
   Nowaczyk, Piotr
   Polom, Karol
TI Use of vacuum-assisted closure in treatment of intestinal fistula-case
   report
SO WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY
LA Polish
DT Article
DE intestinal fistula; vacuum-assisted closure
ID ENTEROCUTANEOUS FISTULAS; WOUND CONTROL; MANAGEMENT; EXPERIENCE
AB Intestinal fistulae are severe complications of gastrointestinal tract operations. Vacuum-assisted closure is one method to treat them. VAC promotes wound heating by increased blood flow through the wound, faster granulation, removal of excess wound fluid and decrease in bacterial colonization. Nowadays the method is commonly used in treatment of stomach compartment syndrome, infected wounds, leg ulceration, as supportive therapy in skin grafting and burn wounds. Another application of the device is intestinal fistula. The aim of the report is case presentation of a patient with intestinal fistula successfully treated by vacuum-assisted closure.
C1 [Spychala, Arkadiusz; Murawa, Dawid; Nowaczyk, Piotr; Polom, Karol] Wielkopolskie Ctr Onkol, Oddzial Chirurg Onkol & Ogolnej 1, PL-61866 Poznan, Poland.
C3 Wielkopolskie Centrum Onkologii
RP Spychala, A (通讯作者)，Wielkopolskie Ctr Onkol, Oddzial Chirurg Onkol & Ogolnej 1, Ul Garbary 15, PL-61866 Poznan, Poland.
EM a_spychala@wp.pl
RI Nowaczyk, Piotr/AAO-5213-2020; Polom, Karol/ABI-6795-2020
OI Nowaczyk, Piotr/0000-0002-6605-7646; Polom, Karol/0000-0003-2011-4155
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Campos ACL, 1999, J AM COLL SURGEONS, V188, P483, DOI 10.1016/S1072-7515(99)00038-1
   Cro C, 2002, POSTGRAD MED J, V78, P364, DOI 10.1136/pmj.78.920.364
   Goverman J, 2006, J TRAUMA, V60, P428, DOI 10.1097/01.ta.0000203588.66012.c4
   Lynch AC, 2004, ANN SURG, V240, P825, DOI 10.1097/01.sla.0000143895.17811.e3
   MCINTYRE PB, 1984, BRIT J SURG, V71, P293, DOI 10.1002/bjs.1800710416
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Rao M, 2007, COLORECTAL DIS, V9, P266, DOI 10.1111/j.1463-1318.2006.01154.x
   SOETERS PB, 1979, ANN SURG, V190, P189, DOI 10.1097/00000658-197908000-00012
NR 12
TC 0
Z9 0
U1 0
U2 1
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA WENEDOW ST 9-1, POZNAN, 61-614, POLAND
SN 1428-2526
J9 WSPOLCZESNA ONKOL
JI Wspolczesna Onkol.
PY 2008
VL 12
IS 10
BP 461
EP 464
PG 4
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 445UB
UT WOS:000266075900006
DA 2026-07-24
ER
PT J
AU Tocco, MP
   Costantino, A
   Ballardini, M
   D'Andrea, C
   Masala, M
   Merico, E
   Mosillo, L
   Sordini, P
AF Tocco, Maria Pia
   Costantino, Alberto
   Ballardini, Mitva
   D'Andrea, Claudio
   Masala, Marcello
   Merico, Eusebio
   Mosillo, Luigi
   Sordini, Paolo
TI Improved results of the vacuum assisted closure and Nitinol clips
   sternal closure after postoperative deep sternal wound infection
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Deep sternal wound infection; Post-sternotomy mediastinitis; Vacuum
   assisted closure; Nitinol clips
ID POSTSTERNOTOMY MEDIASTINITIS; THERAPY
AB Objective: Postoperative deep sternal wound infection is a severe complication of cardiac surgery, with a high mortality rate and a high morbidity rate. The objective of this prospective study is to report our experience with the vacuum assisted closure (VAC) system for the management of deep wound infection. We also devised an innovative closure technique post VAC therapy using thermo reactive clips. The advantage of this technique is that the posterior face of the sternum does not have to be separated from the mediastinal structures thus minimising the risk of damage. Methods: From October 2006 to October 2008, we prospectively evaluated 21 patients affected by mediastinitis after sternotomy. Nineteen patients had sternotomy for coronary artery bypass grafting (CABG), one patient for aortic valve replacement (AVR) and another one for ascending aortic replacement (AAR). All patients were treated with the VAC system at the time of infection diagnosis. When the wound tissue appeared viable and the microbiological cultures were negative, the chest was closed using the most suitable procedure for the patient in question; nine patients were closed using pectoralis flaps, nine patients using Nitinol clips, one patient with a combined technique (use of Nitinol clips and muscle flap), one patient with a direct wound closure and another patient, who needed AAR with a homograft performed in another institution, was closed using sternal wires. Results: We had no mortality; wound heating was successfully achieved in all patients. In more than 50% of the patients, the VAC therapy allowed direct sternal resynthesis. The average duration of the vacuum therapy was 26 days (range 1437 days). Conclusions: VAC is a safe and effective option in the treatment of post-sternotomy mediastinitis, with excellent survival and immediate improvement of local wound conditions; furthermore, the use of Nitinol clips after VAC therapy demonstrated to be a safe and non-invasive option for sternal resynthesis. After VAC therapy, a reduction in number of muscular flaps used and an increase of direct sternal resynthesis were observed. (C) 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
C1 [Tocco, Maria Pia; D'Andrea, Claudio; Mosillo, Luigi] S Filippo Neri Hosp, Thorac Surg Unit, Rome, Italy.
   [Costantino, Alberto; Merico, Eusebio; Sordini, Paolo] S Filippo Neri Hosp, Cardiac Surg Unit, Rome, Italy.
   [Ballardini, Mitva] S Filippo Neri Hosp, Microbiol Unit, Rome, Italy.
   [Masala, Marcello] S Filippo Neri Hosp, Dept Anaesthesia, Rome, Italy.
C3 San Filippo Neri Hospital; San Filippo Neri Hospital; San Filippo Neri
   Hospital; San Filippo Neri Hospital
RP Tocco, MP (通讯作者)，ACOS Filippo Neri, Thorac Surg Unit, Via G Martinotti 20, I-00135 Rome, Italy.
EM mptocco@yahoo.it
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Centofanti P, 2002, ANN THORAC SURG, V74, P943, DOI 10.1016/S0003-4975(02)03674-3
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Eklund AM, 2006, ANN THORAC SURG, V82, P1784, DOI 10.1016/j.athoracsur.2006.05.097
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Gårdlund B, 2002, EUR J CARDIO-THORAC, V21, P825, DOI 10.1016/S1010-7940(02)00084-2
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Lecharny JB, 2001, C ACT, P677
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Negri A, 2002, EUR J CARDIO-THORAC, V22, P571, DOI 10.1016/S1010-7940(02)00411-6
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Reiss N, 2007, ANN THORAC SURG, V83, P2246, DOI 10.1016/j.athoracsur.2006.07.077
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
NR 16
TC 26
Z9 27
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD MAY
PY 2009
VL 35
IS 5
BP 833
EP 838
DI 10.1016/j.ejcts.2008.12.036
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 446QX
UT WOS:000266137300018
PM 19216084
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Steiert, AE
   Gohritz, A
   Schreiber, TC
   Krettek, C
   Vogt, PM
AF Steiert, Andreas E.
   Gohritz, Andreas
   Schreiber, Thomas C.
   Krettek, Christian
   Vogt, Peter M.
TI Delayed flap coverage of open extremity fractures after previous
   vacuum-assisted closure (VAC®) therapy - worse or worth?
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Open fractures; Soft tissue damage; Microsurgery; Delayed; Flap
   reconstruction
ID OPEN TIBIAL FRACTURES; DAMAGE CONTROL; MULTIPLE INJURIES; WOUND CLOSURE;
   RECONSTRUCTION; MANAGEMENT; CLASSIFICATION; DEFECTS; SALVAGE; TRAUMA
AB Background: Controversy remains regarding timing in the management of complex traumatic lower extremity defects. Many authors recommend a definitive bony and soft tissue reconstruction within a critical period of 72 h, yet in many patients this may be impossible due to concomitant injuries or delayed referral. However, little data are available on the results of delayed flap reconstruction of complex traumatic extremity defects, especially using new technologies of wound coverage such as vacuum-assisted closure (VAC (R)) therapy which may reduce the disadvantages of conventional open wound therapy prior to a subsequent flap reconstruction.
   Methods: We retrospectively analysed the soft tissue reconstructions in 43 open extremity fractures during a 4-year period with special regard to complications, overall flap loss and wound infection.
   Results: A total of 29 mate and 13 female patients with 33 open fractures of the tower and 10 of the upper extremity were included. All patients had been referred from a trauma centre at a mean interval of 19 days (range 1-96 days) after the trauma event with temporary VAC (R) of their wounds after initial fracture fixation and initial debridement of necrotic tissue. Flap reconstruction was thus only possible later than 72 h and definitive wound closure was achieved at a mean time of 28 days (range 3-106 days). Overall, three pedicled flaps were lost and one of 38 microsurgical free flaps (2.6%) underwent necrosis, the cause of which was unrelated to treatment delay.
   Conclusions: According to this study, the flap reconstructions performed beyond the frequently quoted critical interval yielded similar results to those of immediate reconstruction within the first 3 days, as reported in the literature.
   This strategy is in accordance with the principles of 'Damage Control Orthopaedics (DCO)' and may reduce the importance of emergency reconstructions, especially in poly-traumatised patients. (C) 2008 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.
C1 [Steiert, Andreas E.; Gohritz, Andreas; Vogt, Peter M.] Hannover Med Sch, Dept Plast Hand & Reconstruct Surg, D-30623 Hannover, Germany.
   [Schreiber, Thomas C.; Krettek, Christian] Hannover Med Sch, Dept Trauma Surg, D-30623 Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School
RP Steiert, AE (通讯作者)，Hannover Med Sch, Dept Plast Hand & Reconstruct Surg, Carl Neuberg Str 1, D-30623 Hannover, Germany.
EM steiert.andreas@mh-hannover.de
RI Vogt, Peter/AAL-1332-2020
OI Krettek, Christian/0000-0001-9807-0020
CR *AM COLL SURG COMM, 2004, ADV TRAUM LIV SUPP A
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 31
TC 91
Z9 103
U1 2
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAY
PY 2009
VL 62
IS 5
BP 675
EP 683
DI 10.1016/j.bjps.2007.09.041
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 447RQ
UT WOS:000266209900028
PM 18373969
DA 2026-07-24
ER
PT J
AU Nordmyr, J
   Svensson, S
   Björck, M
   Acosta, S
AF Nordmyr, J.
   Svensson, S.
   Bjorck, M.
   Acosta, S.
TI Vacuum assisted wound closure in patients with lower extremity arterial
   disease
SO INTERNATIONAL ANGIOLOGY
LA English
DT Article
DE Negative-pressure wound therapy; Wound healing; Arterial occlusive
   diseases; Amputation, mortality
ID INFECTION; THERAPY; FOOT; PRESERVATION
AB Aim. The purpose of this investigation was to analyze predictors for wound healing, amputation and mortality after vacuum assisted closure (VAC (R)) therapy of wounds in the lower limb in patients with arterial disease.
   Methods. One hundred and twenty one wounds were treated and followed for 12 months at two vascular centres in Uppsala and Malmo, Sweden. VAC (R) therapy was applied in the wound at a topical negative pressure of 125 mmHg.
   Results. Median age of the patients was 74 years and critical lower limb ischemia was present in 87% of the patients at admission. Intestinal flora was cultivated in 74% of the wounds. VAC (R) associated bleeding occurred in four patients. Complete wound healing was achieved in 66%. Deep groin infections were associated with synthetic graft infection (P<0.001), treatment outside hospital (P<0.001), faster healing (P<0.01) and lower amputation rate (P<0.005). Diabetes mellitus (OR 2.7; [95% CI 1.2-6.2]) and foot wound (OR 3.0; (95% CI 1.2-7.4]) were independent predictors for amputation. The absence of complete wound healing was the strongest factor for both amputation (P<0.001) and death (P<0.001).
   Conclusion. VAC (R) therapy of complex wounds in the lower limbs in patients with vascular disease was associated with high healing rates. Non-healed wounds after VAC (R) therapy were predictors for amputation and death. [Int Angiol 2009;28:26-3 1]
C1 [Svensson, S.; Acosta, S.] Malmo Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
   [Nordmyr, J.; Bjorck, M.] Univ Uppsala Hosp, Inst Surg Sci, Vasc Surg Sect, Uppsala, Sweden.
   [Nordmyr, J.] Norrkoping Cty Hosp, Dept Surg, Norrkoping, Sweden.
C3 Lund University; Skane University Hospital; Uppsala University; Uppsala
   University Hospital
RP Acosta, S (通讯作者)，Malmo Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
EM stefan.acosta@telia.com
RI Acosta, Stefan/JAX-3225-2023; Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798; Acosta, Stefan/0000-0002-8895-6001
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Banwell P E., 2003, J Wound Care, V12, P28
   Barani J, 2005, J VASC SURG, V42, P75, DOI 10.1016/j.jvs.2005.03.025
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   Brehm V, 2006, J VASC SURG, V44, P226, DOI 10.1016/j.jvs.2006.02.060
   Dosluoglu HH, 2005, J VASC SURG, V42, P989, DOI 10.1016/j.jvs.2005.07.006
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 18
TC 13
Z9 14
U1 0
U2 2
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0392-9590
EI 1827-1839
J9 INT ANGIOL
JI Int. Angiol.
PD FEB
PY 2009
VL 28
IS 1
BP 26
EP 31
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 448HU
UT WOS:000266254500005
PM 19190552
DA 2026-07-24
ER
PT J
AU Gurvich, L
AF Gurvich, Leon
TI Synergism in Using Negative Pressure Wound Therapy With Alternated
   Applications of Autologous Platelet-derived Growth Factors in Treating
   Post-acute Surgical Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID RICH PLASMA
AB Chronic and acute wounds with long tunneling or undermining are always a challenge to wound care providers. One of the most frequently employed treatments for closing tunneled or undermined wounds is negative pressure wound therapy (NPWT). The benefits of this treatment system are widely discussed in the professional literature, and will not be covered here. Even though NPWT allows for faster wound healing initially, in some cases, progress to wound closure is limited and healing stops after reaching a maximum potential, which may occur after just a few weeks. This adverse phenomenon is more common when the wound exhibits deep tunneling or has been extensively undermined. Trying variations of NPWT strategies geared toward closing these wounds is usually unsuccessful. This article describes cases where combined therapy, using the V.A.C.(R) Therapy System (KCl, San Antonio, Tex) and the autologous platelet-derived gel, AutoloGel (TM), (Cytomedix, Rockville, Md) was employed.
C1 L Weiss Mem Hosp Wound Healing Ctr, Chicago, IL 60640 USA.
RP Gurvich, L (通讯作者)，L Weiss Mem Hosp Wound Healing Ctr, 4646 N Marine Dr, Chicago, IL 60640 USA.
EM leon_gurvich@hotmail.com
CR Carter CA, 2003, EXP MOL PATHOL, V74, P244, DOI 10.1016/S0014-4800(03)00017-0
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Niezgoda JA, 2006, PLAST RECONSTR SURG, V117, p24E, DOI 10.1097/01.prs.0000200776.13868.02
   Pietrzak WS, 2005, J CRANIOFAC SURG, V16, P1043, DOI 10.1097/01.scs.0000186454.07097.bf
   Wrotniak Maciej, 2007, Ortop Traumatol Rehabil, V9, P227
NR 5
TC 7
Z9 8
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2009
VL 21
IS 5
BP 134
EP 140
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 448XL
UT WOS:000266295200005
PM 25903320
DA 2026-07-24
ER
PT J
AU Windhofer, C
   Karlbauer, A
   Papp, C
AF Windhofer, Christian
   Karlbauer, Alois
   Papp, Christoph
TI Bone, Tendon, and Soft Tissue Reconstruction in One Stage With the
   Composite Tensor Fascia Lata Flap
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE TFL flap; composite; bone; tendon; and soft tissue reconstruction; one
   stage; osteomyelitis; posttraumatic
ID TOTAL KNEE ARTHROPLASTY; LOWER-EXTREMITY; EXTENSOR MECHANISM; DEFECTS;
   GRAFT; TIBIA; OSTEOMYELITIS; COMPLICATIONS; MANAGEMENT; FRACTURES
AB A 46-year-old patient sustained a dia-infracondylar tibial fracture after a ski accident. Open reduction and internal fixation (ORIF) was carried out. After an initially uneventful postoperative course the patient was readmitted because of local and systemic infection signs. Radical surgical debridement was carried out following by Vacuum-Assisted Closure (VAC) therapy. The resulting defect consisted of bone defect of the tibia tuberosity, and complete loss of the patellar tendon and the overlying soft tissue. Reconstruction was carried out with a combined tensor fascia lata (TFL) flap including the TFL muscle with the ilio-tibial tract, vascularized part of the iliac crest and the overlying soft tissue. Bone healing took place without signs of osteomyelitis recurrence, and full weight bearing was possible 4 months after reconstruction. Successful reconstruction of the patellar tendon using the ilio-tibial tract, enables the patient full active knee joint motion. The soft tissue coverage shows stable conditions. The donor site showed inconspicuous healing without pain and normal range of motion of the hip joint. So this composite TFL flap is an interesting flap not only for defects following trauma, but also for combined defects following extensive infections after knee implants.
C1 [Windhofer, Christian; Papp, Christoph] Hosp Barmherzigen Bruder, Dept Plast & Reconstruct Surg, A-5020 Salzburg, Austria.
   [Karlbauer, Alois] AUVA Traumaclin Salzburg, Salzburg, Austria.
C3 Konventhospital Der Barmherzigen Bruder
RP Windhofer, C (通讯作者)，Hosp Barmherzigen Bruder, Dept Plast & Reconstruct Surg, Kajetanerpl 1, A-5020 Salzburg, Austria.
EM windhofer@utanet.at
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NR 30
TC 4
Z9 6
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2009
VL 62
IS 6
BP 665
EP 668
DI 10.1097/SAP.0b013e31817e9c0f
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 451CD
UT WOS:000266447400021
PM 19461282
DA 2026-07-24
ER
PT J
AU van Koperen, PJ
   Henegouwen, MIV
   Rosman, C
   Bakker, CM
   Heres, P
   Slors, JFM
   Bemelman, WA
AF van Koperen, P. J.
   Henegouwen, M. I. van Berge
   Rosman, C.
   Bakker, C. M.
   Heres, P.
   Slors, J. F. M.
   Bemelman, W. A.
TI The Dutch multicenter experience of the Endo-Sponge treatment for
   anastomotic leakage after colorectal surgery
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article; Proceedings Paper
CT 16th Annual Meeting of the European-Association-of-Endoscopic-Surgery
   (EAES)
CY JUN 11-14, 2008
CL Stockholm, SWEDEN
SP European Assoc Endoscop Surg (EAES)
DE Anastomotic leakage; Rectal surgery; Vacuum-assisted closure
ID RECTAL-CANCER; RISK-FACTORS; MESORECTAL EXCISION; ANTERIOR RESECTION;
   IMPACT
AB Anastomotic leakage is a feared complication following colorectal surgery and is associated with early and long-term morbidity and mortality. The presacral cavity as the result of leakage can be treated with an endo-sponge (B-Braun Medical). The aim of this study was to assess the effectiveness of endo-sponge treatment of the presacral cavity as the result of anastomotic leakage in the Netherlands.
   Between July 2006 and April 2008, 16 patients (M/F = 9:7) with median age 64 years (range 19-78 years) who underwent surgery for rectal cancer (n = 13) or ulcerative colitis (n = 3) were treated with the endo-sponge treatment after anastomotic leakage.
   Of the 16 patients, eight patients started with the endo-sponge treatment within 6 weeks after the initial surgery. In these patients the endo-sponge was placed after a median of 24 days (range 13-39 days) following surgery. In the remaining eight patients the endo-sponge treatment was started later than 6 weeks after the initial surgery. In this group there was a median of 74 days (range 43-1,602 days) between surgery and the start of endo-sponge placement. There was closure in six out of eight patients (75%) in the group that started with the endo-sponge treatment within 6 weeks of surgery compared with three out of eight patients (38%) in the group that started later (p = 0.315). Closure was achieved in a median of 40 (range 28-90) days with a median number of 13 sponge replacements (range 8-17).
   Endo-sponge placement can be helpful in the treatment for anastomotic leakage after colorectal surgery and might prevent a chronic presacral sinus. However, it is not yet clear if this new treatment modality results in quicker healing.
C1 [van Koperen, P. J.; Henegouwen, M. I. van Berge; Slors, J. F. M.; Bemelman, W. A.] Univ Amsterdam, Acad Med Ctr, Dept Surg, NL-1100 A2 Amsterdam DD, Netherlands.
   [Rosman, C.] Canisius Wilhelmina Hosp, Dept Surg, Nijmegen, Netherlands.
   [Bakker, C. M.] Atrium Med Ctr, Dept Gastroenterol, Heerlen, Netherlands.
   [Heres, P.] Waterland Hosp, Dept Surg, Purmerend, Netherlands.
C3 University of Amsterdam; Canisius-Wilhelmina Hospital; Atrium Medical
   Center
RP Bemelman, WA (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Surg, POB 22660, NL-1100 A2 Amsterdam DD, Netherlands.
EM p.j.vankoperen@amc.uva.nl; w.a.bemelman@amc.uva.nl
RI rosman, camiel/F-9059-2016; Bemelman, Wilhelmus/AAA-1635-2021
OI rosman, camiel/0000-0002-9152-3987; van Berge Henegouwen,
   Mark/0000-0001-8689-3134; 
CR Hallbook O, 1996, BRIT J SURG, V83, P60, DOI 10.1002/bjs.1800830119
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   Jestin P, 2008, COLORECTAL DIS, V10, P715, DOI 10.1111/j.1463-1318.2007.01466.x
   Jung SH, 2008, DIS COLON RECTUM, V51, P902, DOI 10.1007/s10350-008-9272-x
   Law WL, 2004, ANN SURG, V240, P260, DOI 10.1097/01.sla.0000133185.23514.32
   Lee WS, 2008, WORLD J SURG, V32, P1124, DOI 10.1007/s00268-007-9451-2
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NR 16
TC 119
Z9 133
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD JUN
PY 2009
VL 23
IS 6
BP 1379
EP 1383
DI 10.1007/s00464-008-0186-4
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 451GG
UT WOS:000266458100033
PM 19037698
OA Green Published, Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Paulsson, P
   Mokhtari, A
   Gesslein, B
   Hlebowicz, J
   Malmsjö, M
   Ingemansson, R
AF Lindstedt, Sandra
   Paulsson, Per
   Mokhtari, Arash
   Gesslein, Bodil
   Hlebowicz, Joanna
   Malmsjo, Malin
   Ingemansson, Richard
TI A compare between myocardial topical negative pressure levels of-25 mmHg
   and-50 mmHg in a porcine model
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; ENDOTHELIAL GROWTH-FACTOR;
   LASER DOPPLER FLOWMETRY; BYPASS GRAFT-SURGERY; BLOOD-FLOW;
   CARDIOPULMONARY BYPASS; CONTROLLED-TRIAL; WOUND THERAPY; MEDIASTINITIS
AB Background: Topical negative pressure (TNP), widely used in wound therapy, is known to stimulate wound edge blood flow, granulation tissue formation, angiogenesis, and revascularization. We have previously shown that application of a TNP of -50 mmHg to the myocardium significantly increases microvascular blood flow in the underlying tissue. We have also shown that a myocardial TNP levels between -75 mmHg and -150 mmHg do not induce microvascular blood flow changes in the underlying myocardium. The present study was designed to elucidate the difference between -25 mmHg and -50 mmHg TNP on microvascular flow in normal and ischemic myocardium.
   Methods: Six pigs underwent median sternotomy. The microvascular blood flow in the myocardium was recorded before and after the application of TNP using laser Doppler flowmetry. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium), and after 20 minutes of LAD occlusion (ischemic myocardium).
   Results: A TNP of -25 mmHg significantly increased microvascular blood flow in both normal (from 263.3 +/- 62.8 PU before, to 380.0 +/- 80.6 PU after TNP application, *p = 0.03) and ischemic myocardium (from 58.8 +/- 17.7 PU before, to 85.8 +/- 20.9 PU after TNP application, *p = 0.04). A TNP of -50 mmHg also significantly increased microvascular blood flow in both normal (from 174.2 +/- 20.8 PU before, to 240.0 +/- 34.4 PU after TNP application, *p = 0.02) and ischemic myocardium (from 44.5 +/- 14.0 PU before, to 106.2 +/- 26.6 PU after TNP application, **p = 0.01).
   Conclusion: Topical negative pressure of -25 mmHg and -50 mmHg both induced a significant increase in microvascular blood flow in normal and in ischemic myocardium. The increase in microvascular blood flow was larger when using -25 mmHg on normal myocardium, and was larger when using -50 mmHg on ischemic myocardium; however these differences were not statistically significant.
C1 [Lindstedt, Sandra; Paulsson, Per; Mokhtari, Arash; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Gesslein, Bodil; Malmsjo, Malin] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
   [Hlebowicz, Joanna] Malmo Univ Hosp, Dept Med, Malmo, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se; per.paulsson@skane.se;
   arash.mokhtari@kane.se; bodil.gesslein@med.lu.se;
   joanna.hlebowicz@skane.se; malin.malmsjo@med.lu.se;
   richard.ingemansson@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Ingemansson,
   Richard/0000-0001-7623-8953; Maljö, Malin/0000-0001-9849-9599
FU Anders Otto Sward Foundation/Ulrika Eklund Foundation; Anna Lisa and
   Sven Eric Lundgren's Foundation for Medical Research; Ake Wiberg
   Foundation; M. Bergvall Foundation; Swedish Medical Association; Royal
   Physiographic Society in Lund; Swedish Medical Research Council;
   Crafoord Foundation
FX This study was supported by the Anders Otto Sward Foundation/Ulrika
   Eklund Foundation, Anna Lisa and Sven Eric Lundgren's Foundation for
   Medical Research, the Ake Wiberg Foundation, the M. Bergvall Foundation,
   the Swedish Medical Association, the Royal Physiographic Society in
   Lund, the Swedish Medical Research Council, the Crafoord Foundation.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 29
TC 5
Z9 10
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD JUN 22
PY 2008
VL 8
AR 14
DI 10.1186/1471-2261-8-14
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 456NX
UT WOS:000266854800001
PM 18570679
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Cuccia, G
   Mucciardi, G
   Morgia, G
   d'Alcontres, FS
   Galì, A
   Cotrufo, S
   Romeo, M
   Magno, C
AF Cuccia, Giuseppe
   Mucciardi, Giuseppe
   Morgia, Giuseppe
   d'Alcontres, Francesco Stagno
   Gali, Alessandro
   Cotrufo, Stefano
   Romeo, Marco
   Magno, Carlo
TI Vacuum-Assisted Closure for the Treatment of Fournier's Gangrene
SO UROLOGIA INTERNATIONALIS
LA English
DT Article
DE Assessment; Fournier's gangrene; Vacuum-assisted closure; Surgical
   treatment
ID HYPERBARIC-OXYGEN; EXPERIENCE
AB Background: Fournier's gangrene (FG) is a very aggressive necrotizing fasciitis involving subcutaneous fat and skin of scrotal and perineal regions. Vacuum-assisted closure (VAC) is a well-known method used to treat complex wounds. The authors for the first time enhance a multimodal strategy to treat the FG using VAC, reducing the number of surgical debridements, allowing a one-step surgical reconstruction with locoregional fasciocutaneous flap. Methods: Six patients with the diagnosis of FG were reviewed retrospectively at our institution. All patients were affected by very extensive FG. The FG Severity Index (FGSI) was used to evaluate the prognosis of the case at admission. Following the acute phase (24-48 h), VAC was used to achieve wound cleaning and prepare the area to a single-stage reconstruction with superomedial thigh flap. Hyperbaric oxygen therapy was also used before final reconstruction. Results: The average FGSI was 10.5, ranging from 8 to 12. All patients survived and were completely healed at the mean follow-up time of 9 months (range 3-30 months). Conclusions: VAC therapy is effective to clean and prepare the wounds, cutting off the fasciitis process and reducing the hospital stay and patient discomfort. Multidisciplinary treatment is mandatory during this devastating infection. Copyright (C) 2009 S. Karger AG, Basel
C1 [Mucciardi, Giuseppe; Morgia, Giuseppe; Gali, Alessandro; Magno, Carlo] Univ Messina, Dept Urol, Messina, Italy.
   [Cuccia, Giuseppe; d'Alcontres, Francesco Stagno; Cotrufo, Stefano; Romeo, Marco] Univ Messina, Plast Surg Unit, Messina, Italy.
C3 University of Messina; University of Messina
RP Magno, C (通讯作者)，Messina Univ Policlin, Dept Urol, Via Consolare Valeria, IT-98100 Messina, Italy.
EM cmagno@unime.it
OI Morgia, Giuseppe/0000-0002-7224-7577
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NR 23
TC 41
Z9 50
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0042-1138
EI 1423-0399
J9 UROL INT
JI Urol.Int.
PY 2009
VL 82
IS 4
BP 426
EP 431
DI 10.1159/000218532
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 456WQ
UT WOS:000266883200010
PM 19506410
DA 2026-07-24
ER
PT J
AU Ahearn, C
AF Ahearn, Cindy
TI Intermittent Negative Pressure Wound Therapy and Lower Negative
   Pressures - Exploring the Disparity between Science and Current
   Practice: A Review of the Literature
SO OSTOMY WOUND MANAGEMENT
LA English
DT Review
DE review; intermittent negative pressure wound therapy; low pressure;
   regional blood flow; granulation tissue
ID VACUUM-ASSISTED CLOSURE; CELL-GROWTH; BLOOD-FLOW; DEVICES
AB Negative pressure wound therapy (NPWT) is used to treat a wide and growing range of problematic acute and chronic wounds. Continuous therapy delivered at -125 mm Hg has been routinely recommended, despite consistent research findings suggesting potential advantages to the use of lower pressures and intermittent therapy. To enhance understanding and document the disparity between the body of NPWT science and current practice with respect to negative pressure levels and modes of therapy, a search of the English-language literature from June 1989 through May 2009 was conducted. Thirty-six publications found to contain directly relevant information (in vitro, in vivo, and clinical data) were examined. While lower negative pressures and intermittent therapy were associated in earlier studies with improved microvascular blood flow in porcine wound models and with reduced pain in patients, early system shortcomings discourage adoption of intermittent therapy. Subsequent preclinical studies confirmed the beneficial effects of intermittent therapy compared to continuous therapy on blood flow and granulation tissue formation and lower pressures (-75 mm Hg or -100 mm Hg) compared to higher pressure (-125 mm Hg) on soft tissue blood flow. Considering the available preclinical evidence, reported patient pain, and common use of high-pressure continuous NPWT in clinical practice, high-quality randomized controlled clinical trials must be conducted to help clinicians optimize care.
C1 Prospera, Clin Serv, Ft Worth, TX 76107 USA.
RP Ahearn, C (通讯作者)，Prospera, Clin Serv, 2831 Bledsoe St, Ft Worth, TX 76107 USA.
EM cahearn@prospera-npwt.com
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   MALMSJO M, ANN PLAST S IN PRESS
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   2002, SPRINGHOUSE NURSES D
NR 36
TC 23
Z9 24
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2009
VL 55
IS 6
BP 22
EP +
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 463BZ
UT WOS:000267404700006
PM 19564670
DA 2026-07-24
ER
PT J
AU Nease, C
AF Nease, Cheryl
TI Using Low Pressure, Negative Pressure Wound Therapy for Wound
   Preparation and the Management of Split-Thickness Skin Grafts in Three
   Patients with Complex Wounds
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case series; traumatic wounds; skin grafts; low-pressure negative
   pressure therapy
AB The use of negative pressure wound therapy (NPWT) is well established in the management of hard-to-heal wounds. One institution, familiar with NPWT's capabilities as well as its shortcomings (eg,. pain at dressing changes and pain with the maximum recommended setting of 125 mm Hg), sought a viable alternative. A low pressure, negative pressure wound therapy (LP-NPWT) system, using subatmospheric pressure levels of 75 mm Hg and a low-adherence dressing, was evaluated to prepare the wound bed for split-thickness skin graft (STSG) on three patients. One patient was a healthy 23-year-old man with extensive trauma-related soft tissue wounds. The two women - 54 and 47 years old - had multiple comorbidities. One had a lower extremity fasciotomy wound and the other had a dehisced surgical wound with a history of irradiation. Wound area was reduced >60% in all three wounds in 3 to 6 weeks as new granulation tissue developed. The average pain reported was moderate (4 to 5 on a Visual Analogue Scale), ranging from 2 to 10 during dressing changes to 1 to 7 between dressing changes; pain levels reported tended to decrease as therapy progressed. Little or no trauma on dressing removal and no signs of infection were noted. In all cases, STSGs, followed by 4 days of LP-NPWT were applied and all wounds healed. The results from these three cases suggest that the LP-NPWT system is a useful healing adjunct for complex wound bed preparation and graft management. Clinical studies to quantify the effects of LP-NPWT technology and compare its safety and efficacy to other negative pressure systems are needed.
C1 Mem Hlth Univ, Med Ctr, Savannah, GA 31403 USA.
RP Nease, C (通讯作者)，Mem Hlth Univ, Med Ctr, 4700 Waters Ave, Savannah, GA 31403 USA.
EM cnease1987@aol.com
CR Andros G, 2006, WOUNDS, P1
   CAMPBELL P, 2006, J WOCN, V33, P2
   COUPER SG, 2008, 21 ANN S ADV WOUND C
   GIROLAMI S, 2008, 21 ANN S ADV WOUND C
   GIROLAMI S, 2007, 20 ANN S ADV WOUND C
   HILL L, 2007, 20 ANN S ADV WOUND C
   Hunter Judith E, 2007, Int Wound J, V4, P256, DOI 10.1111/j.1742-481X.2007.00361.x
   Krasner Diane L, 2002, Ostomy Wound Manage, V48, P38
   LEE SK, 2008, 21 ANN S ADV WOUND C
   PENNY H, 2008, 3 C WORLD UN WOUND H
   PENNY H, 2008, AM PROF WOUND CAR AS
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Sibbald R Gary, 2003, Ostomy Wound Manage, V49, P52
   TERRELL GS, 1992, SURG GYNECOL OBSTET, V175, P437
   World Union of Wound Healing Societies (WUWHS), 2008, PRINC BEST PRACT VAC
NR 15
TC 21
Z9 23
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2009
VL 55
IS 6
BP 32
EP 42
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 463BZ
UT WOS:000267404700007
PM 19564671
DA 2026-07-24
ER
PT J
AU Beral, D
   Adair, R
   Peckham-Cooper, A
   Tolan, D
   Botterill, I
AF Beral, Daniel
   Adair, Robert
   Peckham-Cooper, Adam
   Tolan, Damian
   Botterill, Ian
TI Lesson of the Week Chronic wound sepsis due to retained vacuum
   assisted closure foam
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Article
C1 [Beral, Daniel; Peckham-Cooper, Adam; Botterill, Ian] Leeds Gen Infirm, John Goligher Colorectal Unit, Leeds, W Yorkshire, England.
   [Tolan, Damian] Leeds Gen Infirm, Dept Clin Radiol, Leeds, W Yorkshire, England.
C3 University of Leeds; Leeds General Infirmary; Leeds General Infirmary;
   University of Leeds
RP Botterill, I (通讯作者)，Leeds Gen Infirm, John Goligher Colorectal Unit, Leeds, W Yorkshire, England.
EM ian.botterill@leedsth.nhs.uk
RI Peckham-Cooper, Adam/AAE-8454-2021; Tolan, Damian/HHN-4673-2022
OI Tolan, Damian/0000-0001-9895-9874
CR Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   Fox A, 2004, J Wound Care, V13, P344
   Gawande AA, 2003, NEW ENGL J MED, V348, P229, DOI 10.1056/NEJMsa021721
   Saeed Musab U, 2007, Int J Low Extrem Wounds, V6, P153, DOI 10.1177/1534734607305597
NR 4
TC 17
Z9 19
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD JUN 24
PY 2009
VL 338
AR b2269
DI 10.1136/bmj.b2269
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 463MO
UT WOS:000267436500008
PM 19553260
DA 2026-07-24
ER
PT J
AU Mayer, D
   Rancic, Z
   Meier, C
   Pfammatter, T
   Veith, FJ
   Lachat, M
AF Mayer, Dieter
   Rancic, Zoran
   Meier, Christoph
   Pfammatter, Thomas
   Veith, Frank J.
   Lachat, Mario
TI Open abdomen treatment following endovascular repair of ruptured
   abdominal aortic aneurysms
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
AB Background: Open abdomen treatment (OAT) is considered a lifesaving procedure in patients with abdominal compartment syndrome (ACS) after endovascular or open intervention for ruptured abdominal aortic aneurysms (RAAA). Standardized treatment methods and algorithms for its use are still lacking. The high, published mortality rates may reflect difficulties in detecting and treating ACS, especially in patients treated by emergency endovascular aneurysm repair (eEVAR). Presented are standardized algorithms for OAT, including a new technique using the vacuum-assisted closure (VAC) system developed during 10 years of experience with eEVAR for RAAA.
   Methods. We retrospectively analyzed 102 patients with RAAA treated by eEVAR from January 1998 to April 2008. Abdominal decompression was done when intravesical pressure >20 mm Hg or when abdominal perfusion pressure was < 50 to 60 mm Hg and concomitant organ deterioration occurred. OAT was initially done with a subcutaneously sutured plastic bag or with a nonsutured zipper drape combined with a VAC device (VAC/ETHIZIP; KCI International Inc, Amstelveen, The Netherlands; Ethicon, Somerville, NJ). All patients were switched to VAC/ETHIZIP as soon as possible. Dressings were generally changed every 3 to 5 days. Intra-abdominal pressure was monitored until stability was observed after delayed direct abdominal closure.
   Results. Overall 30-day mortality for eEVAR was 13% (13 of 102); 8% (7 of 82) for patients without ACS and 30% (6 of 20) for those with ACS. Decompression for ACS was needed in 20 patients (20%) primarily during the intervention (n = 14) or secondarily in the intensive care unit (n = 6). Six of 20 (30%) patients requiring OAT died <= 30 days (4 primary, 2 secondary). A mean of 3.6 (range, 1-12) planned second-look interventions were done per patient at an interval of 3 to 5 days. No bowel lesions were observed. Four patients required antibiotic therapy for abdominal infection, and all infections resolved. Delayed abdominal wall closure (direct closure, 11; closure with polypropylene mesh, 3; bilateral anterior rectus abdominis sheath turnover flap, 1) was achieved after a median of 6 days (range, 1-47 days).
   Conclusion: The use of standardized novel techniques and a treatment Protocol and algorithm for OAT after eEVAR for RAAA were feasible and safe. It decreased the workload of the medical and nursing staff, enhanced patient comfort because the need for dressing changes was minimized, and likely contributed to lower overall mortality in RAAA patients. Delayed direct fascial closure was possible in most patients. (J Vasc Surg 2009;50:1-7.)
C1 [Mayer, Dieter; Rancic, Zoran; Lachat, Mario] Univ Zurich Hosp, Cardiovasc Surg Clin, CH-8091 Zurich, Switzerland.
   NYU, Med Ctr, New York, NY 10016 USA.
   Cleveland Clin, New York, NY USA.
C3 University of Zurich; University Zurich Hospital; New York University;
   Cleveland Clinic Foundation
RP Mayer, D (通讯作者)，Univ Zurich Hosp, Cardiovasc Surg Clin, Raemistr 100, CH-8091 Zurich, Switzerland.
EM dieter.mayer@usz.ch
RI Lachat, Mario/G-4826-2011; Mayer, Dieter/E-7617-2011
OI Lachat, Mario/0000-0001-7812-2110; Mayer, Dieter/0000-0001-5933-7749
CR Acosta S, 2007, EUR J VASC ENDOVASC, V33, P277, DOI 10.1016/j.ejvs.2006.09.017
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NR 41
TC 74
Z9 83
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD JUL
PY 2009
VL 50
IS 1
BP 1
EP 7
DI 10.1016/j.jvs.2008.12.030
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 464IL
UT WOS:000267498500001
PM 19563948
OA Green Accepted, Bronze
DA 2026-07-24
ER
PT J
AU Orgill, DP
   Manders, EK
   Sumpio, BE
   Lee, RC
   Attinger, CE
   Gurtner, GC
   Ehrlich, HP
AF Orgill, Dennis P.
   Manders, Ernest K.
   Sumpio, Bauer E.
   Lee, Raphael C.
   Attinger, Christopher E.
   Gurtner, Geoffrey C.
   Ehrlich, H. Paul
TI The mechanisms of action of vacuum assisted closure: More to learn
SO SURGERY
LA English
DT Review
ID PRESSURE WOUND THERAPY; TOPICAL NEGATIVE-PRESSURE; SUBATMOSPHERIC
   PRESSURE; CELL-SHAPE; PROLIFERATION; PROGRESSION; ULCERS; STRAIN;
   GROWTH; SKIN
C1 [Orgill, Dennis P.] Brigham & Womens Hosp, Div Plast & Reconstruct Surg, Boston, MA 02115 USA.
   [Manders, Ernest K.] Univ Pittsburgh, Sch Med, Div Plast & Reconstruct Surg, Pittsburgh, PA USA.
   [Sumpio, Bauer E.] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06510 USA.
   [Lee, Raphael C.] Univ Chicago Hosp, Dept Surg, Chicago, IL 60637 USA.
   [Attinger, Christopher E.] Georgetown Univ, Med Ctr, Limb Ctr, Washington, DC 20007 USA.
   [Gurtner, Geoffrey C.] Stanford Univ, Med Ctr, Dept Surg, Stanford, CA 94305 USA.
   [Ehrlich, H. Paul] Penn State Univ, Milton S Hershey Med Ctr, Dept Surg, Div Plast Surg, Hershey, PA 17033 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Yale University; University of
   Illinois System; University of Chicago; University of Chicago Medical
   Center; Georgetown University; Stanford University; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast & Reconstruct Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019; Lee, Raphael C/KIE-5231-2024
OI Orgill, Dennis/0000-0002-8279-7310; Lee, Raphael C/0000-0002-6628-1867
FU Kinetic Concepts, Inc. (KCI)
FX Supported by a grant from Kinetic Concepts, Inc. (KCI). This document
   reflects the opinion of the authors and was not influenced by KCI.
CR [Anonymous], LAW BONE REMODELING
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NR 71
TC 210
Z9 253
U1 0
U2 23
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD JUL
PY 2009
VL 146
IS 1
BP 40
EP 51
DI 10.1016/j.surg.2009.02.002
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 464IM
UT WOS:000267498600007
PM 19541009
DA 2026-07-24
ER
PT J
AU Lioupis, C
   Kotsis, T
   Barbatis, C
   Seretis, E
   Nomikos, A
   Volondakis-Baltatzis, I
   Papalois, A
   Andrikopoulos, V
   Leaper, D
AF Lioupis, Christos
   Kotsis, Thomas
   Barbatis, Calypso
   Seretis, Eleni
   Nomikos, Alexandros
   Volondakis-Baltatzis, Irene
   Papalois, Apostolos
   Andrikopoulos, Vasilios
   Leaper, David
TI The Effect of Negative Pressure Therapy on the Femoral Vein Blood Flow
   and Wall Structure
SO ANGIOLOGY
LA English
DT Article
DE negatine pressure therapy; VAC therapy; vacuum-assisted closure;
   deep-vein thrombosis; femoral veins; pigs; hemodynamic effects;
   thrombogenicity
ID VACUUM-ASSISTED CLOSURE; SEQUENTIAL PNEUMATIC COMPRESSION; DEEP VENOUS
   THROMBOSIS; MUSCLE FLAP COVERAGE; GRAFT INFECTIONS; GROIN; PROPHYLAXIS;
   MANAGEMENT; STASIS; INJURY
AB Negative pressure therapy has been recently used for managing lymphatic or infective groin complications. The aim of this study was to investigate any possible association between application of negative pressure therapy in the groin area and deep-vein thrombosis. Acute surgical wounds were created at the inguinal areas in 7 pigs. Different negative pressures ranging from -50 to -200 mmHg were applied directly over the femoral vessels, and blood flow alterations were studied using a Doppler ultrasound. Femoral vein specimens were also removed for histological examination after 12 hours of therapy, It has been demonstrated that negative pressure therapy does not significantly alter the baseline lower limb venous return. Histology demonstrated several changes, which are associated with vein thrombogenesis. The hemodynamic and pathological findings still leave a potential for thrombogenic effects of negative pressure therapy and warrant care to protect the femoral veins, with the use of thrombosis prophylaxis measures.
C1 [Lioupis, Christos; Kotsis, Thomas; Andrikopoulos, Vasilios] Red Cross Hosp Athens, Dept Vasc Surg, Athens, Greece.
   [Barbatis, Calypso; Nomikos, Alexandros] Red Cross Hosp Athens, Dept Histopathol, Athens, Greece.
   [Seretis, Eleni; Volondakis-Baltatzis, Irene] St Savas Anticanc Hosp, Dept Electron Microscopy, Athens, Greece.
   [Papalois, Apostolos] Elpen Pharmaceut, Expt Res Ctr, Athens, Greece.
   [Leaper, David] Cardiff Univ, Wound Healing Res Unit, Cardiff, S Glam, Wales.
C3 Cardiff University
RP Lioupis, C (通讯作者)，59 Dimokratias St, Athens 17563, Greece.
EM christoslioupis@yahoo.gr
OI Lioupis, Christos/0000-0001-6197-3218
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NR 39
TC 2
Z9 2
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
J9 ANGIOLOGY
JI Angiology
PD JUN-JUL
PY 2009
VL 60
IS 3
BP 290
EP 300
DI 10.1177/0003319708318376
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 464MY
UT WOS:000267510400004
PM 18504262
DA 2026-07-24
ER
PT J
AU Ruiz-López, M
   Campos, JC
   Pérez, BS
   Sánchez, AG
   Aguilar, JLF
   Navarro, JAB
AF Ruiz-Lopez, Manuel
   Carrasco Campos, Joaquin
   Sanchez Perez, Belinda
   Gonzalez Sanchez, Antonio
   Fernandez Aguilar, Jose Luis
   Bondia Navarro, Jose Antonio
TI Negative pressure therapy in wounds with enteric fistulas
SO CIRUGIA ESPANOLA
LA Spanish
DT Article
DE Enterocutaneous fistulas; Wounds; Negative-pressure wound therapy
ID VACUUM-ASSISTED CLOSURE
AB Objective: Negative pressure therapy (VAC, vacuum assisted closure) is a method used still in our country. It consists of a system of aspirating a wound by means of a piece of foam and a few adhesive films. It allows the treatment of complex wounds, included (although this is still controversial) those with intestinal fistulas. We present 3 cases of treatment with VAC in this situation and a review of the published literature.
   Patients and method: We have treated 10 patients, since VAC therapy was introduced into our centre of which 3 of whom had a fistula in the bed of the surgical wound. We describe the clinical information of the patients and the therapy that followed in each of the cases.
   Results: Significant local clinical improvement of the disease, with control of the symptoms, was achieved in all 3 cases. We were able to re-operate to close the fistula in one of the patients, with subsequent good progression of the wound. In the other two cases it gave them a better quality of life although both died due to the overall complexity of their situation.
   Conclusions: VAC therapy, although controversial in the treatment of intestinal fistulas, can help to improve the local situation of the wounds, the comfort of the patients and their general situation. (c) 2008 AEC. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Ruiz-Lopez, Manuel; Carrasco Campos, Joaquin; Sanchez Perez, Belinda; Gonzalez Sanchez, Antonio; Fernandez Aguilar, Jose Luis; Bondia Navarro, Jose Antonio] Hosp Reg Carlos Haya, Serv Cirugia Gen & Digest, Malaga, Spain.
C3 Hospital Regional Universitario de Malaga
RP Ruiz-López, M (通讯作者)，Hosp Reg Carlos Haya, Serv Cirugia Gen & Digest, Malaga, Spain.
EM man.rui@terra.es
OI Fernández Aguilar, Jose luis/0009-0003-1304-6809; Sánchez,
   Belinda/0000-0003-1659-5427
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 9
TC 8
Z9 12
U1 0
U2 1
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD JUL
PY 2009
VL 86
IS 1
BP 29
EP 32
DI 10.1016/j.ciresp.2009.01.029
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 468DZ
UT WOS:000267796300006
PM 19486962
DA 2026-07-24
ER
PT J
AU Amtsberg, G
   Frank, M
   Lange, J
   Gondert, M
   Kramer, A
   Ekkernkamp, A
   Hinz, P
AF Amtsberg, G.
   Frank, M.
   Lange, J.
   Gondert, M.
   Kramer, A.
   Ekkernkamp, A.
   Hinz, P.
TI Vacuum-assisted closure and instillation dressing (VAC Instill®) in the
   treatment of open fractures
SO INFECTION
LA English
DT Article; Proceedings Paper
CT 1st VAC Instill Symposium
CY NOV 21, 2008
CL Orthoped Univ Hosp, Heidelberg, GERMANY
HO Orthoped Univ Hosp
C1 [Amtsberg, G.] Ernst Moritz Arndt Univ Greifswald, Univ Hosp Greifswald, Unit Traumatol & Reconstruct Surg, D-17475 Greifswald, Germany.
C3 Universitat Greifswald
RP Amtsberg, G (通讯作者)，Ernst Moritz Arndt Univ Greifswald, Univ Hosp Greifswald, Unit Traumatol & Reconstruct Surg, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany.
EM amtsberg@uni-greifswald.de
CR Dedmond BT, 2007, J ORTHOP TRAUMA, V21, P11, DOI 10.1097/BOT.0b013e31802cbc54
   Fleischmann W, 1998, UNFALLCHIRURG, V101, P649, DOI 10.1007/s001130050318
   FRANK M, 2007, EUR J TRAUMA EMER S2, V33, P82
   HINZ P, 2008, TAGL PRAXIS, V49, P73
   Kramer A., 2004, Hyg Med, V5, P147
   KRAMER A, 2008, MED PRAXIS, V5, P27
   Kramer A., 2008, WALLHAUSSERS PRAXIS, P789
   Ostermann PAW, 1996, ZBL CHIR, V121, P990
   Stengel D, 2001, Lancet Infect Dis, V1, P175, DOI 10.1016/S1473-3099(01)00094-9
NR 9
TC 1
Z9 1
U1 0
U2 1
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0300-8126
J9 INFECTION
JI Infection
PD JUN
PY 2009
VL 37
BP 33
EP 34
PG 2
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Infectious Diseases
GA 473XZ
UT WOS:000268246900010
DA 2026-07-24
ER
PT J
AU Amin, AI
   Shaikh, IA
AF Amin, Amin Ibrahim
   Shaikh, Irshad A.
TI Topical negative pressure in managing severe peritonitis: A positive
   contribution?
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Severe peritonitis; Open abdomen; Topical negative pressure; VAC (R)
   Abdominal Dressing System; VAC (R) GranuFoam (R)
ID VACUUM-ASSISTED CLOSURE; TEMPORARY ABDOMINAL CLOSURE; TRIAL COMPARING
   POLYGLACTIN-910-MESH; VASCULAR SURGICAL-PATIENTS; RANDOMIZED-TRIAL;
   PLANNED REOPERATIONS; COMPARTMENT SYNDROME; WOUND CLOSURE; 258 TRAUMA;
   MANAGEMENT
AB AIM: To assess the use of topical negative pressure (TNP) in the management of severe peritonitis.
   METHODS: This is a four-year prospective analysis from January 2005 to December 2008 of 20 patients requiring TNP following laparotomy for severe peritonitis.
   RESULTS: There were 11 males with an average age of (59.3 +/- 3.95) years. Nine had a perforated viscus, five had anastomotic leaks, three had iatrogenic bowel injury, and a further three had severe pelvic inflammatory disease. TNP and the VAC (R) Abdominal Dressing System were initially used. These were changed every two to three days. Abdominal closure was achieved in 15/20 patients within 4.53 +/- 1.64 d. One patient required relaparotomy due to residual sepsis. Two patients with severe faecal peritonitis due to perforated diverticular disease received primary anastomosis at second look laparotomy, as sepsis and their general condition improved. In the remaining 5/20 cases, the abdomen was left open due to bowel oedema and or abdominal wall oedema. Dressing was switched to TNP and VAC (R) GranuFoam (R). Three of the five patients returned a few months later for abdominal wall reconstruction and restoration of intestinal continuity. Two patients developed intestinal fistulae. All 20 patients survived.
   CONCLUSION: The use of TNP is safe. Further studies are needed to assess its value in managing these difficult cases. (C) 2009 The WJG Press and Baishideng. All rights reserved.
C1 [Amin, Amin Ibrahim] Queen Margaret Hosp, Dept Surg, Dunfermline KY12 0SU, Fife, Scotland.
   [Shaikh, Irshad A.] Royal Infirm Edinburgh NHS Trust, Edinburgh EH16 4SA, Midlothian, Scotland.
C3 Royal Infirmary of Edinburgh; University of Edinburgh
RP Amin, AI (通讯作者)，Queen Margaret Hosp, Dept Surg, Dunfermline KY12 0SU, Fife, Scotland.
EM ibrahim.amin@faht.scot.nhs.uk
CR Adkins AL, 2004, AM SURGEON, V70, P137
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NR 23
TC 44
Z9 49
U1 0
U2 1
PU W J G PRESS
PI BEIJING
PA APT 1066, YISHOU GARDEN, NO 58, NORTH LANGXINZHUANG RD, PO BOX 2345,
   BEIJING 100023, PEOPLES R CHINA
SN 1007-9327
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUL 21
PY 2009
VL 15
IS 27
BP 3394
EP 3397
DI 10.3748/wjg.15.3394
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 474EJ
UT WOS:000268265000008
PM 19610140
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Labanaris, AP
   Polykandriotis, E
   Horch, RE
AF Labanaris, Apostolos P.
   Polykandriotis, Elias
   Horch, Raymund E.
TI The effect of vacuum-assisted closure on lymph vessels in chronic wounds
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Chronic wounds; Vacuum-assisted closure; Lymph vessel proliferation
ID TUMOR LYMPHANGIOGENESIS; RECONSTRUCTIVE SURGERY; MONOCLONAL-ANTIBODY;
   NODE METASTASIS; UPPER EXTREMITY; THERAPY; FLAPS; OSTEOMYELITIS;
   INFECTIONS; FOUNDATION
AB Introduction: Chronic wounds come in various forms and result from a multitude of factors that play a detrimental role in the wound-heating process. A breakthrough in wound management came with the introduction of vacuum-assisted closure (VAC). Although numerous papers have been published suggesting that VAC is based upon its unique ability to accelerate the rate of granulation tissue production, enhance angiogenesis and remove excess chronic wound fluid, no attempts have been made to investigate its effect on lymph vessels.
   Patients and methods: From April 2005 to April 2006, 80 patients with chronic wounds were treated with VAC therapy and prospectively studied. The parameters included: the length of VAC treatment, the number of dressing changes, the number of days of hospitalisation and immunocytochemical lymphatic vessel density assessments.
   Results: Lymph vessel proliferation was noted in all types of wounds, up to the first dressing change, but as VAC therapy continued it was apparent that patients exhibiting the same type of wounds did not exhibit the same results. Additionally, the duration of VAC therapy, dressing changes and average number of days of hospitalisation were significantly less in some cases but also prolonged in others.
   Conclusion: VAC therapy seems to be inducing morphological and quantitative alterations on the lymph vessel network in a wound. The effect of VAC therapy varies greatly depending on the presence of underlying diseases and risk factors impairing wound heating.
   An increase in the density of lymph vessels manifested histologically correlates with a better clinical outcome, in terms of heating rates and hospitalisation time. (C) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Etsevier Ltd. All rights reserved.
C1 [Labanaris, Apostolos P.; Polykandriotis, Elias; Horch, Raymund E.] Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Labanaris, AP (通讯作者)，Stadenstr 60, D-90491 Nurnberg, Germany.
EM labanaris@web.de
RI ; Horch, Raymund E/H-8128-2019
OI Polykaniotis, Elias/0000-0002-8152-6420; Horch, Raymund
   E/0000-0002-6561-2353
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NR 42
TC 43
Z9 51
U1 1
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2009
VL 62
IS 8
BP 1068
EP 1075
DI 10.1016/j.bjps.2008.01.006
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 477JY
UT WOS:000268516500017
PM 18524708
DA 2026-07-24
ER
PT J
AU Atkins, BZ
   Wooten, MK
   Kistler, J
   Hurley, K
   Hughes, GC
   Wolfe, WG
AF Atkins, Broadus Zane
   Wooten, Mary Kay
   Kistler, Jean
   Hurley, Kista
   Hughes, G. Chad
   Wolfe, Walter G.
TI Does Negative Pressure Wound Therapy Have a Role in Preventing
   Poststernotomy Wound Complications?
SO SURGICAL INNOVATION
LA English
DT Article
DE subatmospheric pressure; wound healing; cardiac surgery; median
   sternotomy
ID VACUUM-ASSISTED CLOSURE; BYPASS GRAFT-SURGERY; LONG-TERM SURVIVAL;
   PERISTERNAL THORACIC WALL; SURGICAL-SITE INFECTIONS; RISK-FACTORS;
   BLOOD-FLOW; DEEP; MORTALITY; MEDIASTINITIS
AB Background: Sternal wound infection (SWI) remains a devastating complication after cardiac surgery, decreasing long-term and short-term survival. In treating documented SWI, negative pressure wound therapy (NPWT) reduces wound edema and time to definitive closure and improves peristernal blood flow after internal mammary artery (IMA) harvesting. The authors evaluated NPWT as a form of "well wound" therapy in patients at substantial risk for SWI based on existing risk stratification models. Methods: Records of 57 adult cardiac surgery patients (September 2006 to April 2008) were reviewed. After preoperative risk assessment, NPWT was instituted on the clean, closed sternotomy immediately after surgery and continued 4 days postoperatively. Adverse postoperative events, including SWI, need for readmission, and other complications, were documented. Results: Mean age was 60.4 +/- 10 years, and 89.5% were male; 77.2% were obese (mean body mass index 35.3 +/- 6.7), 54.4% were diabetic, and 29 (50.9%) were both obese and diabetic. Coronary artery bypass (CAB) with single IMA was performed in 50.9% of the patients followed in frequency by combined CAB/valve, non-CAB surgery, and CAB with bilateral IMA. Estimated risk for SWI was 6.1 +/- 4%. All patients tolerated NPWT to completion. Thirty-day and in-hospital mortality was 1.8% and unrelated to DSWI. No treatment of SWI was required. Conclusions: In this high-risk cohort, 3 postoperative SWI cases were anticipated but may have been mitigated by NPWT. This is an easily applied and well-tolerated therapy and may stimulate more effective wound healing. Among patients with increased SWI risk, strong consideration should be given to NPWT as a form of "well wound" therapy.
C1 [Atkins, Broadus Zane; Wooten, Mary Kay; Kistler, Jean; Hurley, Kista; Wolfe, Walter G.] Vet Affairs Med Ctr, Dept Surg, Minnepolis, MN USA.
   [Kistler, Jean; Hughes, G. Chad; Wolfe, Walter G.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Duke University
RP Atkins, BZ (通讯作者)，Surg Serv, 112,508 Fulton St, Durham, NC 27705 USA.
EM Broadus.atkins@va.gov
RI Hughes, G. Chad/NOE-9906-2025
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NR 41
TC 108
Z9 128
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD JUN
PY 2009
VL 16
IS 2
BP 140
EP 146
DI 10.1177/1553350609334821
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 479EQ
UT WOS:000268642900009
PM 19460818
DA 2026-07-24
ER
PT J
AU Karl, T
   Billing, A
   Storck, M
AF Karl, T.
   Billing, A.
   Storck, M.
TI Economic and medical effects of a modern standard wound-healing
   treatment concept
SO GEFASSCHIRURGIE
LA German
DT Review
DE Wound care protocol; Hydroactive covering; VAC therapy; Therapy costs;
   Chronic wounds
ID CARE; DRESSINGS
AB The increasing number of patients with chronic wounds as well as the variety of new products for wound care make the development of a standard regimen necessary. One of the aims of a therapeutic standard is to avoid unnecessary and ineffective wound dressings and to adjust treatment to the stage of the wound-healing process. Additionally, synergistic logistic and economic effects can be achieved.
   A wound care protocol is easy to use, always available, and contains precise instructions. However, the initial phase of the introduction of a standard wound-healing treatment concept in two hospitals resulted in an increase in costs of between 21% and 169% (depending on the aspect). The daily costs for materials alone were between (sic) 7.24 and (sic) 7.26 in 2006 and between (sic) 8.66 and (sic) 8.79 in 2007. For each hospital bed, the costs were between (sic) 248.20 and (sic) 317.45 per year. Reasons for this phenomenon include an increased number of cases, an increase in the case mix index, inexperienced users, and the increased use of expensive treatments such as vacuum-assisted closure systems. Further prospective analyses are necessary to analyse the financial aspects of chronic wound care in major hospitals.
C1 [Karl, T.; Billing, A.] Klinikum Offenbach GmbH, Klin Gefasschirurg, D-63069 Offenbach, Germany.
   [Storck, M.] Stadt Klinikum Karlsruhe, Klin Gefass & Thoraxchirurg, Karlsruhe, Germany.
C3 Sana Klinikum Offenbach; Municipal Hospital Karlsruhe
RP Karl, T (通讯作者)，Klinikum Offenbach GmbH, Klin Gefasschirurg, Starkenburgring 66, D-63069 Offenbach, Germany.
EM dr.t.karl@web.de
RI /L-6893-2017
CR [Anonymous], COCHRANE DATABASE SY
   BRADLEY M, 1999, HLTH TECHNOL ASSES 2, V3
   *BVMED, 2005, WIRTSCH GES EINS HYD
   DEBUS ES, 2003, GEFA CHIRURG, V8, P259
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NR 14
TC 3
Z9 3
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0948-7034
J9 GEFASSCHIRURGIE
JI Gefasschirurgie
PD AUG
PY 2009
VL 14
IS 4
BP 284
EP +
DI 10.1007/s00772-009-0675-3
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 482JB
UT WOS:000268880900005
DA 2026-07-24
ER
PT J
AU Thodis, E
   Kriki, P
   Kakagia, D
   Passadakis, P
   Theodoridis, M
   Mourvati, E
   Vargemezis, V
AF Thodis, Elias
   Kriki, Pelagia
   Kakagia, Despoina
   Passadakis, Ploumis
   Theodoridis, Marios
   Mourvati, Euthymia
   Vargemezis, Vassilios
TI Rigorous Vibrio vulnificus Soft Tissue Infection of the Lower Leg
   in a Renal Transplant Patient Managed by Vacuum Therapy and Autologous
   Growth Factors
SO JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
ID ASSISTED CLOSURE; PRESSURE; FEATURES; WOUNDS
AB Background. Vibrio vulnificus is a gram-negative marine bacterium that grows well in coastal waters. It is an opportunistic pathogen that can cause serious life-threatening infections in patients with certain health conditions. Vibrio-induced wound infections in immunosuppressed patients are difficult to treat because the healing process may be significantly delayed. Reconstructive surgery may not be successful in early treatment as skin grafts are likely to fail, and there may be increased morbidity of donor sites of grafts or flaps.
   Objective Herein a case of septicemia and wound necrosis owing to V. vulnificus wound infection in a renal transplant patient is reported.
   Method. To conservatively yet adequately debride the wound bed, stimulate angiogenesis, and accelerate granulation, vacuum-assisted closure was employed. Granulation was further enhanced by autologous platelet concentrate spray, which has also been reported to increase the epithelialization rate.
   Result: Complete epithelialization of the wound was achieved 4 weeks after completion of treatment.
   Conclusion: Noninvasive advanced modalities may be employed to successfully treat infectious soft tissue deficits in immunocompromised patients.
C1 [Thodis, Elias] Democritus Univ Thrace Hosp, Dept Nephrol, Alexandroupolis, Greece.
   Democritus Univ Thrace Hosp, Dept Plast Surg, Alexandroupolis, Greece.
   Democritus Univ Thrace Hosp, Burns Unit, Alexandroupolis, Greece.
C3 Democritus University of Thrace; Democritus University Thrace Hospital;
   Democritus University of Thrace; Democritus University Thrace Hospital;
   Democritus University of Thrace; Democritus University Thrace Hospital
RP Thodis, E (通讯作者)，Democritus Univ Thrace Hosp, Dept Nephrol, Alexandroupolis, Greece.
RI Theodoridis, Marios/MZQ-5176-2025; Kakagia, Despoina/AAP-1202-2021
OI Theodoridis, Marios/0000-0002-4993-7668; Kakagia,
   Despoina/0000-0003-2107-6170
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   Oliver JD, 2005, EPIDEMIOL INFECT, V133, P383, DOI 10.1017/S0950268805003894
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NR 26
TC 4
Z9 6
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1203-4754
EI 1615-7109
J9 J CUTAN MED SURG
JI J. Cutan. Med. Surg.
PD JUL-AUG
PY 2009
VL 13
IS 4
BP 209
EP 214
DI 10.2310/7750.2008.08033
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 485AO
UT WOS:000269092900005
PM 19706229
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Petzina, R
   Ugander, M
   Engblom, H
   Torbrand, C
   Mokhtari, A
   Hetzer, R
   Arheden, H
   Ingemansson, R
AF Malmsjoe, Malin
   Petzina, Rainer
   Ugander, Martin
   Engblom, Henrik
   Torbrand, Christian
   Mokhtari, Arash
   Hetzer, Roland
   Arheden, Hakan
   Ingemansson, Richard
TI Preventing heart injury during negative pressure wound therapy in
   cardiac surgery: Assessment using real-time magnetic resonance imaging
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; EXPERIENCE;
   RUPTURE
AB Objective: Heart rupture is a devastating complication to negative pressure wound therapy in cardiac surgery. Also, reduced cardiac output during negative pressure wound therapy has been reported. The present study aimed to examine the effects of negative pressure wound therapy on the position of the heart in relation to the thoracic wall using magnetic resonance imaging in a porcine sternotomy wound model.
   Methods: Six pigs had median sternotomy followed by negative pressure wound therapy at -75, -125, and -175 mm Hg. Real-time magnetic resonance imaging movies (10 images/s) were acquired in a midventricular transverse plane or a midsagittal plane during the application of negative pressure wound therapy.
   Results: Similar finding were observed at all different negative pressures studied. Negative pressure wound therapy caused the heart to be displaced toward the thoracic wall, and in some cases, the right ventricular free wall bulged into the space between the sternal edges, and the sharp edges of the sternum jutted into and deformed the anterior surface of the right ventricular free wall. These events were not affected by the interposition of 4 layers of paraffin gauze dressing but were hindered by the placement of a rigid barrier between the anterior portion of the heart and the inside of the thoracic wall.
   Conclusion: The results show altered position of the heart in relation to the sternum during negative pressure wound therapy. This may explain 2 potentially hazardous events associated with negative pressure wound therapy, namely, risk for heart rupture and reduced cardiac output. Inserting a rigid barrier over the heart may be a protective measure that is clinically practicable.
C1 [Malmsjoe, Malin; Petzina, Rainer; Engblom, Henrik] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
   [Ugander, Martin; Engblom, Henrik; Arheden, Hakan] Univ Lund Hosp, Dept Clin Physiol, S-22185 Lund, Sweden.
   [Mokhtari, Arash; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Hetzer, Roland] Deutsch Herzzentrum Berlin, Berlin, Germany.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital; German
   Heart Center Berlin
RP Malmsjö, M (通讯作者)，Lund Univ, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Ugander, Martin/AAQ-4447-2021; Torbrand, Christian/HIZ-8092-2022
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953; Ugander, Martin/0000-0003-3665-2038;
   Petzina, Rainer/0000-0002-0688-5482; Torbrand,
   Christian/0000-0001-6442-7554
FU Ake Wiberg Foundation; M. Bergvall Foundation; Swedish Medical
   Association; Royal Physiographic Society in Lund; Swedish Medical
   Research Council; Crafoord Foundation; Swedish HeartLung Foundation;
   Lund University Faculty of Medicine; Swedish Government Grant for
   Clinical Research; Swedish Hypertension Society
FX This study was supported by the Ake Wiberg Foundation, the M. Bergvall
   Foundation, the Swedish Medical Association, the Royal Physiographic
   Society in Lund, the Swedish Medical Research Council, the Crafoord
   Foundation, the Swedish HeartLung Foundation, Lund University Faculty of
   Medicine, the Swedish Government Grant for Clinical Research and the
   Swedish Hypertension Society.
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Banwell Paul, 2006, J Tissue Viability, V16, P16
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NR 15
TC 29
Z9 30
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD SEP
PY 2009
VL 138
IS 3
BP 712
EP 717
DI 10.1016/j.jtcvs.2008.11.068
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 488BC
UT WOS:000269323000028
PM 19698860
OA Bronze
DA 2026-07-24
ER
PT J
AU Graham, JS
   Stevenson, RS
   Mitcheltree, LW
   Hamilton, TA
   Deckert, RR
   Lee, RB
   Schiavetta, AM
AF Graham, John S.
   Stevenson, Robert S.
   Mitcheltree, Larry W.
   Hamilton, Tracey A.
   Deckert, Robin R.
   Lee, Robyn B.
   Schiavetta, Ann M.
TI Medical management of cutaneous sulfur mustard injuries
SO TOXICOLOGY
LA English
DT Article
DE Sulfur mustard; Wound healing; Pig; Skin; Treatment; Medical management
ID HUMAN EPIDERMAL-KERATINOCYTES; IRANIAN VETERANS; LATE COMPLICATIONS;
   LASER DEBRIDEMENT; RANDOMIZED-TRIAL; SKIN-LESIONS; FIBRIN-GLUE; BURNS;
   WOUNDS; GAS
AB Background: Sulfur mustard (2,2'-dichlorodiethyl sulfide; HD) is a potent vesicating chemical warfare agent that poses a continuing threat to both military and civilian populations. Significant cutaneous HD injuries can take several months to heal, necessitate lengthy hospitalizations, and result in long-term complications. There are currently no standardized or optimized methods of casualty management. New strategies are needed to provide for optimal and rapid wound healing.
   Objective: The primary aim of this research was to develop improved clinical strategies (treatment guidelines) for optimal treatment of superficial dermal (second degree) cutaneous HD injuries, with the goal of returning damaged skin to optimal appearance and normal function in the shortest period of time.
   Methods: Superficial dermal HD injuries were created on the ventral abdominal surface of weanling pigs. At 48 h post-exposure, lesions were laser debrided and a treatment adjunct applied. Cultured epithelial allografts and 11 commercial off-the-shelf (COTS) products were examined for their efficacy in improving wound healing of these injuries. Clinical evaluations and a variety of non-invasive bioengineering methods were used at 7 and 14 days post-surgery to follow the progress of wound healing and evaluate various cosmetic and functional properties of the wounds. Measurements included reflectance colorimetry to measure erythema: evaporimetry to examine transepidermal water loss as a method of evaluating barrier function; torsional ballistometry to evaluate the mechanical properties of skin firmness and elasticity; and two-dimensional high frequency ultrasonography (HFU) to monitor skin thickness (e.g., edema, scar tissue). Histopathology and immunohistochemistry were performed 14 days following surgery to examine structural integrity and quality of healing. Logical Decisions (R) for Windows was used to rank the 12 treatment adjuncts that were studied.
   Results: The most efficacious treatment adjuncts included (1) Vacuum Assisted Closure (TM), V.A.C.(R), involving application of topical negative pressure, (2) Amino-Plex (R) Spray (biO(2) Cosmeceuticals International, Inc., Beverly Hills, CA), a nutritive cosmeceutical product that is designed to increase oxygen in cells, stimulate ATP synthesis, improve glucose transportation, stimulate collagen formation, and promote angiogenesis, and (3) ReCell (R) Autologous Cell Harvesting Device (Clinical Cell Culture Americas LLC, Coral Springs. Florida), an innovative medical device that was developed to allow rapid harvesting of autologous cells from a thin split-thickness biopsy followed by spray application of a population of skin cells onto wounds within 30 min of collecting the biopsy, without the need of culturing the keratinocytes in a clinical laboratory.
   Conclusions: Complete re-epithelialization of debrided HD injuries in 7 days is possible. In general, shallow laser debridement through the basement membrane zone (100 mu m) appears to provide better results than deeper debridement (400 mu m) with respect to early re-epithelialization, cosmetic appearance, functional restoration, and structural integrity Of the 12 treatment adjuncts examined, the most promising included Vacuum Assisted Closur (TM), Amino-Plex (R) Spray, and ReCell (R) Autologous Cell Harvesting Device. Published by Elsevier Ireland Ltd.
C1 [Graham, John S.; Stevenson, Robert S.; Deckert, Robin R.] USA, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
   [Mitcheltree, Larry W.; Hamilton, Tracey A.] USA, Comparat Pathol Branch, Div Comparat Med, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
   [Lee, Robyn B.] USA, Program S3, Strategies & Operat Off, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
   [Schiavetta, Ann M.] USA, Vet Med & Surg Branch, Div Comparat Med, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
C3 Research Institute of Chemical Defense - China; Research Institute of
   Chemical Defense - China; Research Institute of Chemical Defense -
   China; Research Institute of Chemical Defense - China
RP Graham, JS (通讯作者)，USA, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM john.s.graham1@us.army.mil; rob.stevenson1@us.army.mil;
   larry.mitcheltree@us.army.mil; tracey.hamilton@us.army.mil;
   robin.deckert@us.army.mil; robyn.lee2@us.army.mil;
   ann.schiavetta@us.army.mil
FU Plastic Surgery Associates of Northern Virginia, LTD, McLean, VA
FX The authors wish to thank MAJ Stephen Dalal, D.V.M. and MAJ Ann
   Schiavetta's staff for veterinary support; F. Steven Tucker and staff
   for clinical pathology support; Jamie Martin and staff for histology
   support; and Bruce Freedman, MD, FACS (Plastic Surgery Associates of
   Northern Virginia, LTD, McLean, VA) for guidance in use of the Sciton
   Profile laser.
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NR 49
TC 38
Z9 43
U1 0
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD SEP 1
PY 2009
VL 263
IS 1
SI SI
BP 47
EP 58
DI 10.1016/j.tox.2008.07.067
PG 12
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 489HX
UT WOS:000269412200010
PM 18762227
DA 2026-07-24
ER
PT J
AU Stannard, JP
   Volgas, DA
   Stewart, R
   McGwin, G
   Alonso, JE
AF Stannard, James P.
   Volgas, David A.
   Stewart, Rena
   McGwin, Gerald, Jr.
   Alonso, Jorge E.
TI Negative Pressure Wound Therapy After Severe Open Fractures: A
   Prospective Randomized Study
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy; osteomyelitis; VAC; severe open
   fractures; orthopaedic trauma
ID VACUUM-ASSISTED CLOSURE; OPEN TIBIAL FRACTURES; SOFT-TISSUE INJURIES;
   SUBATMOSPHERIC PRESSURE; CLINICAL-EXPERIENCE; GRADE-IIIB; MANAGEMENT;
   INFECTION; SHAFT; OSTEOMYELITIS
AB Objectives: To evaluate the impact of negative pressure wound therapy (NPWT) after severe open fractures on deep infection.
   Design: Prospective randomized study.
   Setting: Academic level I trauma center.
   Patients/Participants: Fifty-nine patients with 63 severe high-energy open fractures were enrolled in this study, with data available on 58 patients with 62 open fractures.
   Intervention: Twenty-three patients with 25 fractures randomized to the control group and underwent initial irrigation and debridement followed by standard fine mesh gauze dressing, with repeat irrigation and debridement every 48-72 hours until wound closure. Thirty-five patients randomized to the NPWT group and had identical treatment except that NPWT was applied to the wounds between irrigation and debridement procedures until closure.
   Main Outcome Measurements: The presence or absence of deep wound infection. or osteomyelitis, wound dehiscence, and fracture union were primary outcome measures.
   Results and Conclusions: Control patients developed 2 acute infections (8%) and 5 delayed infections (20%), for a total of 7 deep infections (28%), whereas NPWT patients developed 0 acute infections, 2 delayed infections (5.4%), for a total of 2 deep infections (5.4%). There is a significant difference between the groups for total infections (P = 0.024). The relative risk ratio is 0.199 (95% confidence interval: 0.045-0.874), suggesting that patients treated with NPWT were only one-fifth as likely to have an infection compared with patients randomized to the control group. NPWT represents a promising new therapy for severe open fractures after high-energy trauma.
C1 [Stannard, James P.; McGwin, Gerald, Jr.] Univ Alabama, Div Orthopaed Surg, Dept Epidemiol, Birmingham, AL 35294 USA.
   [McGwin, Gerald, Jr.] Callahan Eye Fdn Hosp, Birmingham, AL USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Stannard, JP (通讯作者)，Univ Alabama, Div Orthopaed Surg, Dept Epidemiol, 950 Fac Off Tower,510 S 20th St, Birmingham, AL 35294 USA.
EM james.stannard@ortho.uab.edu
OI Stannard, James P/0000-0001-8467-6494
FU Kinetics Concepts, Inc, San Antonio, TX
FX The research upon which this article is based was funded through a grant
   to J. R Stannard, MD, from Kinetics Concepts, Inc, San Antonio, TX.
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NR 42
TC 253
Z9 295
U1 3
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2009
VL 23
IS 8
BP 552
EP 557
DI 10.1097/BOT.0b013e3181a2e2b6
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 489ZF
UT WOS:000269465000002
PM 19704269
DA 2026-07-24
ER
PT J
AU Danielsson, PA
   Fredriksson, C
   Huss, FRM
AF Danielsson, Par A.
   Fredriksson, Camilla
   Huss, Fredrik R. M.
TI A Novel Concept for Treating Large Necrotizing Fasciitis Wounds With
   Bilayer Dermal Matrix, Split-thickness Skin Grafts, and Negative
   Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID STREPTOCOCCAL INFECTIONS
AB Treatment of necrotizing fasciitis (NF) includes radical surgical debridement often resulting in large wounds that need to be closed with methods including split-thickness skin grafts (STSG), local flaps, or guided tissue regeneration procedures. In this case report, a 45 year-old Caucasian male was surgically treated for a benign left groin hernia, developed NF, and was transferred to the authors' burn unit. The wound was treated initially with wide debridement and with a brief delay before finally closing the wound. A collagen matrix such as Integra (R) Dermal Regeneration Template (Integra LifeSciences, Plainsboro, NJ) in combination with STSG and negative pressure wound treatment, can provide fast recovery resulting in pliable, functional skin.
C1 [Danielsson, Par A.; Fredriksson, Camilla; Huss, Fredrik R. M.] Linkoping Univ Hosp, Dept Plast Hand & Burn Surg, S-58185 Linkoping, Sweden.
C3 Linkoping University
RP Fredriksson, C (通讯作者)，Linkoping Univ Hosp, Dept Plast Hand & Burn Surg, S-58185 Linkoping, Sweden.
EM Fredrik.huss@lio.se
RI Huss, Fredrik/G-6951-2018
OI Huss, Fredrik/0000-0002-9735-1434
FU Institute of Biomedicine and Surgery; Faculty Of Health Sciences,
   Linkoping Universitet, Linkoping, Sweden
FX We express our sincere gratitude to Mrs. Kristina Briheim and Mrs. Anita
   Lonn, Senior Laboratory Technicians at the Laboratory for Experimental
   Plastic Surgery, Institute of Biomedicine and Surgery, Faculty Of Health
   Sciences, Linkoping Universitet, Linkoping, Sweden.
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NR 11
TC 6
Z9 6
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2009
VL 21
IS 8
BP 215
EP 220
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 490BU
UT WOS:000269472900006
PM 25903675
DA 2026-07-24
ER
PT J
AU Stannard, JP
   Atkins, BZ
   O'Malley, D
   Singh, H
   Bernstein, B
   Fahey, M
   Masden, D
   Attinger, CE
AF Stannard, James P.
   Atkins, Broadus Zane
   O'Malley, David
   Singh, Hardayal
   Bernstein, Brent
   Fahey, Michael
   Masden, Derek
   Attinger, Christopher E.
TI Use of Negative Pressure Therapy on Closed Surgical Incisions: A Case
   Series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; PERISTERNAL THORACIC
   WALL; WOUND THERAPY; BLOOD-FLOW; MULTICENTER
AB Multiple patient comorbidities and environmental factors increase the risk of incisional wound complications. The literature suggests that negative pressure therapy (NPT) on clean closed surgical incisions may help reduce the risk of wound infections and other complications. In this case study, NPT was applied in the operating room to clean closed surgical wounds in four high-risk patients (two men, two women) following coronary artery bypass grafting using bilateral internal mammary arteries, transmetatarsal amputation, and abdominal hysterectomy. All wounds healed well. These results and currently available information suggest that prospective, randomized, controlled clinical studies to assess the safety, efficacy and cost-effectiveness of NPT in the prevention of postoperative wound complications are warranted. In addition, if studies confirm the validity and reliability of the proposed patient grading system discussed, it may help guide use of NPT in postsurgical patients.
C1 [Stannard, James P.] Univ Alabama Birmingham, Sch Med, Dept Orthopaed Trauma, Birmingham, AL USA.
   [Atkins, Broadus Zane] VA Med Ctr, Durham, NC USA.
   [O'Malley, David] Ohio State Univ, James Graham Brown Canc Ctr, Coll Med, Columbus, OH 43210 USA.
   [O'Malley, David] Ohio State Univ, Coll Med, Solove Res Inst, Columbus, OH 43210 USA.
   [Singh, Hardayal] SE Orthoped Sports Med & Shoulder Ctr, Raleigh, NC USA.
   [Bernstein, Brent] St Lukes Hosp, Charcot & Reconstruct Foot Program, Allentown, PA USA.
   [Bernstein, Brent] St Lukes Hosp, Charcot & Reconstruct Foot Program, Bethlehem, PA USA.
   [Fahey, Michael] Fremont Rideout Hlth Grp, Yuba City, CA USA.
   [Attinger, Christopher E.] Georgetown Univ Hosp, Dept Surg Otolaryngol & Orthopaed Surg, Washington, DC 20007 USA.
   [Attinger, Christopher E.] Georgetown Limb Ctr, Washington, DC USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; James Cancer Hospital & Solove Research
   Institute; Georgetown University
RP Stannard, JP (通讯作者)，Care Of Martinez R R, KCI Med Dept, San Antonio, TX USA.
EM ricardo.martinez@kci1.com
RI /AAQ-9524-2020
OI Stannard, James P/0000-0001-8467-6494
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NR 24
TC 1
Z9 2
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2009
VL 21
IS 8
BP 221
EP 228
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 490BU
UT WOS:000269472900007
PM 25903674
DA 2026-07-24
ER
PT J
AU Franczyk, M
   Lohman, RF
   Agarwal, JP
   Rupani, G
   Drum, M
   Gottlieb, LJ
AF Franczyk, Mieczyslawa
   Lohman, Robert F.
   Agarwal, Jayant P.
   Rupani, Gita
   Drum, Melinda
   Gottlieb, Lawrence J.
TI The Impact of Topical Lidocaine on Pain Level Assessment during and
   after Vacuum-Assisted Closure Dressing Changes: A Double-Blind,
   Prospective, Randomized Study
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID LOCAL-ANESTHESIA; MANAGEMENT; LACERATIONS; NO
AB Background: Vacuum-assisted closure dressing changes are frequently painful. The authors hypothesized that administering topical lidocaine into the vacuum-assisted closure sponge would decrease pain during dressing changes.
   Methods: A double-blind, randomized, prospective study was performed on patients (n = 70) undergoing vacuum-assisted closure dressing changes at a single institution between October of 2003 and June of 2005. Patients were randomized to receive either 0.2% lidocaine or 0.9% saline administered through the vacuum-assisted closure tubing into the foam dressing 30 minutes before changing the dressing. All patients received morphine sulfate ad libitum. Pain scores were assessed according to a 0 to 10 numeric pain scale.
   Results: Wound characteristics and patient demographics were similar for both groups. Patients receiving lidocaine reported less pain than control patients during the dressing change (4.3 versus 6.3; p = 0.005) and immediately after (2.4 versus 4.7; p < 0.001) the dressing change. Thirty minutes after the dressing change, pain scores were similar in both groups. Thirty minutes after the dressing change, more patients in the lidocaine group requested small doses of narcotics (> 3 mg morphine equivalent) than in the control group.
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C1 [Lohman, Robert F.] Cleveland Clin Fdn, Dept Plast Surg, Cleveland, OH 44195 USA.
   Univ Chicago, Med Ctr, Dept Therapy Serv, Chicago, IL 60637 USA.
   Univ Chicago, Med Ctr, Dept Anesthesiol & Crit Care, Chicago, IL 60637 USA.
   Univ Chicago, Med Ctr, Sect Plast Surg, Chicago, IL 60637 USA.
   Univ Utah, Div Plast Surg, Salt Lake City, UT USA.
   Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA.
C3 Cleveland Clinic Foundation; University of Chicago; University of
   Chicago Medical Center; University of Chicago; University of Chicago
   Medical Center; University of Chicago; University of Chicago Medical
   Center; Utah System of Higher Education; University of Utah; University
   of Chicago
RP Lohman, RF (通讯作者)，Cleveland Clin Fdn, Dept Plast Surg, Desk A-60,9500 Euclid Ave, Cleveland, OH 44195 USA.
EM lohmanr@ccf.org
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NR 28
TC 31
Z9 35
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2009
VL 124
IS 3
BP 854
EP 861
DI 10.1097/PRS.0b013e3181b038b4
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 490FT
UT WOS:000269485200019
PM 19730304
DA 2026-07-24
ER
PT J
AU Ollat, D
   Bouchard, A
   Tramond, B
   Nuzzaci, F
   Barbier, O
   Versier, G
AF Ollat, Didier
   Bouchard, A.
   Tramond, B.
   Nuzzaci, F.
   Barbier, O.
   Versier, G.
TI Vacuum-assisted closure: a low-cost negative pressure system for wound
   management
SO EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
LA English
DT Article
DE Vacuum-assisted closure; Negative pressure therapy; Wound; Humanitarian
   surgery
ID EXPERIENCE; THERAPY
AB Negative pressure dressings are helpful for humanitarian surgery for healing infected and late-treated large wounds and also wounds with large loss of skin. However, specific commercial device has high costs that are prohibitive for precarious surgery with limited funds and an austere environment. Our idea is to make a negative pressure dressing using only low-cost and non-specific surgical devices. We describe a technical device of negative pressure in which only low-cost disposable medical equipments were used. The vacuum comes from a surgical room electric pump or from a single-use suction canister. Our successful experience suggests that this low-cost alternative method of negative pressure dressing can be safely used in countries with limited health care systems.
C1 [Ollat, Didier; Bouchard, A.; Barbier, O.; Versier, G.] Hop Instruct Armees Begin, Serv Chirurg Orthoped & Traumatol, F-94160 St Mande, France.
   [Tramond, B.] Hop Instruct Armees Laveran, Serv Chirurg Orthoped & Traumatol, F-13000 Marseille, France.
   [Nuzzaci, F.] Hop Mil Instruct, Serv Chirurg Orthoped & Traumatol, Ndjamena, Chad.
RP Ollat, D (通讯作者)，Hop Instruct Armees Begin, Serv Chirurg Orthoped & Traumatol, 69 Paris, F-94160 St Mande, France.
EM didier.ollat@neuf.fr
RI Barbier, Olivier/Z-2116-2019
CR Akhtar S, 2006, ANN PLAS SURG, V56, P700, DOI 10.1097/01.sap.0000214870.57943.f7
   Andreassen GS, 2006, ACTA ORTHOP, V77, P820, DOI 10.1080/17453670610013051
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NR 8
TC 2
Z9 3
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1633-8065
J9 EUR J ORTHOP SURG TR
JI Eur. J. Orthop. Surg. Traumatol.
PD OCT
PY 2009
VL 19
IS 7
BP 505
EP 509
DI 10.1007/s00590-009-0458-2
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 495GW
UT WOS:000269879800012
DA 2026-07-24
ER
PT J
AU Pauniaho, SL
   Costa, J
   Boken, C
   Turnock, R
   Baillie, CT
AF Pauniaho, Satu-Liisa
   Costa, Janet
   Boken, Carole
   Turnock, Rick
   Baillie, Colin T.
TI Vacuum drainage in the management of complicated abdominal wound
   dehiscence in children
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE VAC therapy; Complex; Abdomen; Wound; Children; Neonate
ID ASSISTED CLOSURE SYSTEM; FISTULA; THERAPY
AB Purpose: The aim of the study was to report the outcomes of the vacuum dressing method (vacuum-assisted closure [VAC]) in the management of "complicated" abdominal wounds in a selected group of children including neonates.
   Methods: All children with vacuum (VAC) dressing-assisted closure of a complex abdominal wound (defined as complete/partial wound dehiscence combined with at least one of stoma, anastomosis, tube enterostomy, or infected patch abdominoplasty) were included in a 2-year study that took place in a single tertiary referral hospital. Retrospective case note analysis was used to determine premorbid diagnosis, management, illness severity markers, morbidity, and outcome.
   Results: Nine children (neonate to 16 years) required 11 continuous episodes of VAC therapy. Abdominal wall dehiscence was complete in 7 and partial in 4 episodes. These were complicated by stomas (8), anastomoses (3), enterocutaneous fistulae (3), tube enterostomy (1), and infected patch abdominoplasty (2). Illness severity was assessed by the following proxy physiologic markers: American Society of Anesthesiologists status 3 or more (10), intensive care unit (ICU) (7), inotropes (4), ventilation (7), septic (C-reactive protein >100 and blood culture-positive) (3), liver impairment (aspartate transaminase >58 and alanine transaminase >36) (4), coagulopathy (international normalized ratio >1.3) (4), proinflammatory state (platelet count >450) (5), and nutritional impairment (albumin <37) (9). The median VAC treatment time was 32 days (range, 9-101 days). Of the changes, 70% required a general anesthetic or sedation on ICU. Control of 10 of I I complex abdominal wounds (including 3 established enterocutaneous fistulae) was achieved using VAC therapy. Complications included nonreduction of laparostomy (1), failure of anastomosis (1), and failure of tube enterostomy diversion (1). Four children died of unrelated causes, 2 of them more than 3 months after VAC therapy.
   Conclusions: in our experience with a small series of patients, VAC therapy is both safe and effective in complex pediatric abdominal wounds in severely ill children. It appears to promote wound closure, controls local sepsis, and can be used to manage established fistulae. However, our results suggest that recent bowel anastomoses may be compromised using VAC, which in this circumstance, should be used with caution. (c) 2009 Elsevier Inc. All rights reserved.
EM satu-liisa.pauniaho@fimnet.fi
OI Pauniaho, Satu-Liisa/0000-0002-8212-9240
CR Adamkova M, 2005, Acta Chir Plast, V47, P24
   Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
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   Uygur F, 2008, INT WOUND J, V5, P50, DOI 10.1111/j.1742-481X.2007.00362.x
NR 18
TC 14
Z9 16
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD SEP
PY 2009
VL 44
IS 9
BP 1736
EP 1740
DI 10.1016/j.jpedsurg.2009.01.009
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 497MY
UT WOS:000270065100017
PM 19735817
DA 2026-07-24
ER
PT J
AU Sepúlveda, G
   Espíndola, M
   Maureira, M
   Sepúlveda, E
   Fernández, JI
   Oliva, C
   Sanhueza, A
   Vial, M
   Manterola, C
AF Sepulveda, Gustavo
   Espindola, Manuel
   Maureira, Mauricio
   Sepulveda, Edgardo
   Ignacio Fernandez, Jose
   Oliva, Claudia
   Sanhueza, Antonio
   Vial, Manuel
   Manterola, Carlos
TI Negative-pressure wound therapy versus standard wound dressing in the
   treatment of diabetic foot amputation. A randomised controlled trial
SO CIRUGIA ESPANOLA
LA Spanish
DT Article; Proceedings Paper
CT 44th Chilean Congress on Cardiology and Cardiovascular Surgery
CY DEC, 2007
CL Vina del Mar, CHILE
DE Diabetic foot; Negative-pressure wound therapy; Topical negative
   pressure therapy; Vacuum assisted closure; Negative-pressure dressings
ID VACUUM-ASSISTED CLOSURE; ULCERS; MULTICENTER; VALIDATION; INFECTION;
   ISCHEMIA; COST; RISK; SKIN
AB Introduction: Foot amputation wounds in patients with diabetes are complex and treatment is often difficult. At the moment negative pressure wound therapy (NPWT) is widely used for the treatment of several types of wounds. Nevertheless, the clinical evidence to support the application of this dressing in foot amputation wounds in patients with diabetes is scarce. The aim of this study was to evaluate the efficacy of NPWT compared with standard wound dressing to treat diabetic foot amputation wounds.
   Patients and method: Randomised controlled trial. Diabetic patients aged 18 years or older with a foot amputation wound were assigned to treatment with NPWT (A group) or standard wound dressing (B group). Primary efficacy end point was time in reaching 90% of wound granulation. A size of sample of 11 patients per group was used. NPWT was prepared with a polyurethane ether foam dressing, a Nelaton catheter, a transparent adhesive drape and continuous negative pressure of 100 mmHg. The wound was treated every 48-72 h and evaluated weekly. Descriptive and analytical statistics were used.
   Results: There were 24 patients, with a mean age of 61.8 +/- 9 years (79% men), 12 in each group. The average time to reach 90% of granulation was lower in A group (18.8 +/- 6 days versus 32.3 +/- 13.7 days), a statistically significant difference (P = 0.007).
   Conclusion: NPWT reduces the granulation time of diabetic foot amputation wounds by 40%, compared with the standard wound dressing. (C) 2009 AEC. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Sepulveda, Gustavo; Espindola, Manuel; Maureira, Mauricio; Sepulveda, Edgardo; Ignacio Fernandez, Jose; Oliva, Claudia] Hosp Dipreca, Serv Cirugia Vasc, Santiago, Chile.
   [Sanhueza, Antonio; Vial, Manuel; Manterola, Carlos] Univ La Frontera, Fac Med, Dept Cirugia & Traumatol, Temuco, Chile.
C3 Universidad de La Frontera
RP Sepúlveda, G (通讯作者)，Hosp Dipreca, Serv Cirugia Vasc, Santiago, Chile.
EM dr.gsepulveda@gmail.com
RI ; Manterola, Carlos/F-8826-2013; Vial, Manuel/KZW-9713-2024
OI FERNANDEZ, JOSE IGNACIO/0009-0004-6487-9699; Manterola,
   Carlos/0000-0001-9213-2905; Vial, Manuel/0000-0003-0278-2969
CR Abbott CA, 2005, DIABETES CARE, V28, P1869, DOI 10.2337/diacare.28.8.1869
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NR 47
TC 63
Z9 81
U1 0
U2 18
PU ELSEVIER DOYMA SL
PI BARCELONA
PA TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD SEP
PY 2009
VL 86
IS 3
BP 171
EP 177
DI 10.1016/j.ciresp.2009.03.020
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 497SI
UT WOS:000270081900008
PM 19616774
DA 2026-07-24
ER
PT J
AU Kiliç, A
   Özkaya, U
   Sökücü, S
   Basilgan, S
   Kabukçuoglu, Y
AF Kilic, Ayhan
   Ozkaya, Ufuk
   Sokucu, Sami
   Basilgan, Seckin
   Kabukcuoglu, Yavuz
TI Use of vacuum-assisted closure in the topical treatment of surgical site
   infections
SO ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
LA Turkish
DT Article
DE Negative-pressure wound therapy; wound healing; wound infection/therapy
ID PRESSURE WOUND THERAPY; PROSPECTIVE RANDOMIZED-TRIAL; MANAGEMENT;
   DEVICE; TRAUMA
AB Objectives: This study was designed to evaluate the results of vacuum-assisted closure in the topical treatment of surgical site infections.
   Methods: Vacuum therapy was performed in 17 patients (10 males, 7 females; mean age 60 20 years) using the VAC system (Vacuum-Assisted Closure, Kinetic Concept Inc) for the treatment of surgical site infections. Infective wounds were in the hip (n=6), crus (n=5), knee (n=3), sacrum (n=2), and hand (n=1). The causative organism for infections was gram-positive bacteria in 15 patients (88.2%), and six patients (35.3%) had nosocomial infections. The wounds were treated with a negative pressure of 100-125 mmHg applied continuously for the first two days, and then intermittently for the following days. The mean follow-up period was 11 +/- 6 months.
   Results: The mean duration of vacuum therapy was 16 +/- 4 days and the mean length of hospitalization was 31 +/- 19 days. The patients underwent a mean number of three surgical procedures (range 1 to 6) before vacuum therapy. The mean amount of discharge from the wound was 500 +/- 150 ml. Tissue edema and discharge problems were resolved in all the wounds and a hygienic and dry-looking surgical site was attained. In 11 patients (64.7%), clinical and bacteriologic eradication of infections was achieved at the surgical site through antibiotic use and vacuum therapy. Six patients with nosocomial infections continued to receive antibiotic treatment following resolution of surgical site problems. The mean wound area showed a significant reduction from 36 +/- 14 cm(2) to 11 +/- 10 cm(2) following vacuum therapy (p<0.05). Only two patients (11.8%) required further surgical interventions for the closure of wound site. Two patients (11.8%) complained of pain associated with vacuum application.
   Conclusion: Besides its topical advantages in the care of infected wounds, vacuum-assisted closure provides a more rapid and comfortable treatment opportunity, representing a reliable alternative to conventional wound care methods.
C1 [Kilic, Ayhan; Ozkaya, Ufuk; Sokucu, Sami; Basilgan, Seckin; Kabukcuoglu, Yavuz] Taksim Egitim & Arastirma Hastanesi, Ortopedi & Travmatol Klin, TR-34433 Istanbul, Turkey.
C3 Istanbul Gaziosmanpasa Taksim Training & Research Hospital
RP Kiliç, A (通讯作者)，Taksim Egitim & Arastirma Hastanesi, Ortopedi & Travmatol Klin, TR-34433 Istanbul, Turkey.
EM kilicayhan@yahoo.com
RI Kilic, Ayhan/A-6577-2018
OI Sokucu, Sami/0000-0001-9079-100X
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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   Wongworawat MD, 2003, CLIN ORTHOP RELAT R, P45, DOI 10.1097/01.blo.0000084400.53464.02
NR 28
TC 8
Z9 9
U1 0
U2 3
PU TURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY
PI ISTANBUL
PA SEHREMINI MAH KOYUNCU SK CIGDEM APT NO 4 D 5 FATIH, ISTANBUL, 00000,
   TURKEY
SN 1017-995X
J9 ACTA ORTHOP TRAUMATO
JI Acta Orthop. Traumatol. Turc.
PD JUL-AUG
PY 2009
VL 43
IS 4
BP 336
EP 342
DI 10.3944/AOTT.2009.336
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 500XB
UT WOS:000270338400009
PM 19809231
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Palmen, M
   van Breugel, NAM
   Geskes, GG
   van Belle, A
   Swennen, JMH
   Drijkoningen, AHM
   van der Hulst, RR
   Maessen, JG
AF Palmen, Meindert
   van Breugel, Nathalie A. M.
   Geskes, Gijs G.
   van Belle, Arne
   Swennen, Jos M. H.
   Drijkoningen, Andre H. M.
   van der Hulst, Rene R.
   Maessen, Jos G.
TI Open Window Thoracostomy Treatment of Empyema Is Accelerated by
   Vacuum-Assisted Closure
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID WOUNDS
AB Background. Recurrent thoracic empyema in the presence of residual lung tissue can be treated with an open window thoracostomy (OWT). Vacuum-assisted closure (VAC) of these large thoracic defects is a novel option.
   Methods. Nineteen patients with residual lung tissue received an OWT for treatment of recurrent thoracic empyema. In this retrospective case series, 8 patients (aged 58 +/- 20 years, all male) were treated conventionally, and 11 patients (aged 53 +/- 17 years, 8 male) were treated with VAC.
   Results. The application of the VAC system resulted in rapid debridement of the thoracic cavity and reexpansion of the residual lung tissue. The duration of OWT and VAC therapy was 39 +/- 17 and 31 +/- 19 days, respectively. All 11 patients were amenable for subsequent closure using pedicled muscular flaps. In 2 patients, VAC therapy alone resulted in complete closure of the OWT. The average duration of follow-up was 46 +/- 19 months. All patients, except 1, have recovered well. One patient died of nonpulmonary causes. In the non-VAC group (n = 8), the OWT was managed conventionally by application of saline-soaked gauzes. In 2 patients, the OWT was eventually closed using pedicled muscular flaps (after 75 and 440 days, respectively). Four patients died of OWT-related complications (1 bleeding, 3 recurrent infections) during follow-up; 1 patient died of a cause unrelated to OWT. The average duration of OWT was 933 +/- 1,422 days.
   Conclusions. When compared with conventional management of OWT, VAC therapy accelerates wound healing and improves reexpansion of residual lung tissue in patients with OWT after empyema, allowing rapid surgical closure. (Ann Thorac Surg 2009;88:1131-7) (C) 2009 by The Society of Thoracic Surgeons
C1 [Maessen, Jos G.] Maastricht Univ, Med Ctr, Dept Cardiothorac Surg, NL-6202 AZ Maastricht, Netherlands.
   Maastricht Univ, Med Ctr, Dept Pulmonol, NL-6202 AZ Maastricht, Netherlands.
   Maastricht Univ, Med Ctr, Dept Plast & Reconstruct Surg, NL-6202 AZ Maastricht, Netherlands.
   Leiden Univ, Med Ctr, Dept Cardiothorac Surg, Leiden, Netherlands.
C3 Maastricht University; Maastricht University; Maastricht University;
   Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC)
RP Maessen, JG (通讯作者)，Maastricht Univ, Med Ctr, Dept Cardiothorac Surg, P Debeyelaan 25, NL-6202 AZ Maastricht, Netherlands.
EM j.g.maessen@mumc.nl
RI Palmen, Meindert/GYV-4054-2022
OI Palmen, Meindert/0000-0002-7213-5452
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 13
TC 49
Z9 67
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2009
VL 88
IS 4
BP 1131
EP 1137
DI 10.1016/j.athoracsur.2009.06.030
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 501NL
UT WOS:000270388500012
PM 19766795
DA 2026-07-24
ER
PT J
AU Steigelman, MB
   Norbury, KC
   Kilpadi, DV
   McNeil, JD
AF Steigelman, Megan B.
   Norbury, Kenneth C.
   Kilpadi, Deepak V.
   McNeil, Jeffrey D.
TI Cardiopulmonary Effects of Continuous Negative Pressure Wound Therapy in
   Swine
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; RIGHT-VENTRICULAR
   RUPTURE; BLOOD-FLOW; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   STERNAL WOUNDS; MANAGEMENT; DEVICE; BRIDGE
AB Background. Negative pressure wound therapy (NPWT) has been used for complex sternotomy wounds. Some reports describe foam placement below the posterior sternal table. We compared the hemodynamic and pulmonary effects of foam location during NPWT after median sternotomy.
   Methods. Swine were randomized into four groups (n = 6 per group). A polyurethane open cell foam dressing was placed either within or below the sternal table. In one-half, a silicone mesh barrier was placed between the heart and the foam. The NPWT was applied at -125 mm Hg and then released to ambient pressure. This cycle was repeated two more times, and the foam was removed. Heart rate, mean arterial pressure, cardiac output, mixed venous oxygenation, central venous pressure, and pulmonary artery wedge pressure were measured. Peak inspiratory pressure, mean airway pressure, work of breathing, and intrathoracic pressure measurements were recorded.
   Results. Intersternal placement of foam did not affect hemodynamic parameters. Substernal placement resulted in depression of hemodynamic variables which improved when negative pressure was applied. Pulmonary mechanics were not affected by foam location.
   Conclusions. Initial placement of the foam dressing below the posterior sternal table caused reversible depression of cardiac function which appears to be consistent with direct cardiac compression. NPWT therapy had no clinically significant impact on pulmonary parameters. The use of a protective barrier does not alter hemodynamic or pulmonary parameters but continues to be recommended when NPWT is used for sternotomy wounds. (Ann Thorac Surg 2009; 88: 1277-83) (C) 2009 by The Society of Thoracic Surgeons
C1 [McNeil, Jeffrey D.] Univ Texas Hlth Sci Ctr San Antonio, Div Cardiothorac Surg, Dept Surg, San Antonio, TX 78229 USA.
   Wilford Hall USAF Med Ctr, Dept Surg, Lackland AFB, TX 78236 USA.
   Global R& Kinet Concepts Inc, Dept Physiol & Models, San Antonio, TX USA.
C3 University of Texas System; University of Texas at San Antonio; United
   States Department of Defense; United States Air Force
RP McNeil, JD (通讯作者)，Univ Texas Hlth Sci Ctr San Antonio, Div Cardiothorac Surg, Dept Surg, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM mcneil@uthscsa.edu
FU Cooperative Research and Development Agreement between Wilford Hall
   Medical Center and Kinetic Concepts Inc
FX The authors wish to thank SSgt Tanya Green, Gene Deck, Barbara Collins,
   and Crissy Jenschke for their technical assistance, Mark Borromeo for
   preparing the figures, Zhenmei Liu for statistical analysis, and George
   Hutchinson, Margaret Marsh, Shannon Crenshaw, Nadeem Bridi, Deborah
   Shanley, and Royce Johnson for reviewing the manuscript. The opinions
   expressed in this paper are solely those of the authors and do not
   represent the views of the United States Air Force, United States
   Department of Defense, or the United States Government. This project was
   entirely supported by a Cooperative Research and Development Agreement
   between Wilford Hall Medical Center and Kinetic Concepts Inc.
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
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NR 23
TC 6
Z9 6
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2009
VL 88
IS 4
BP 1277
EP 1283
DI 10.1016/j.athoracsur.2009.06.027
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 501NL
UT WOS:000270388500034
PM 19766821
OA Bronze
DA 2026-07-24
ER
PT J
AU Doughty, D
AF Doughty, Dorothy
TI WOC Nurse Wound Consult Negative Pressure Wound Therapy
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
ID HERNIA REPAIR
C1 Emory Univ, WOCNEC, Atlanta, GA 30322 USA.
C3 Emory University
RP Doughty, D (通讯作者)，Emory Univ, WOCNEC, Atlanta, GA 30322 USA.
EM ddought@emory.edu
CR Candage R, 2008, SURGERY, V144, P703, DOI 10.1016/j.surg.2008.06.018
   Frantz R.A., 2007, Acute and chronic wounds; current management concepts, V3e, P427
   Hiles M, 2009, SURG INNOV, V16, P26, DOI 10.1177/1553350609331397
   Taner T, 2009, DIS COLON RECTUM, V52, P349, DOI 10.1007/DCR.0b013e31819a3e69
NR 4
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1071-5754
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2009
VL 36
IS 5
BP 483
EP 485
DI 10.1097/WON.0b013e3181b51f84
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 501ZK
UT WOS:000270423200003
PM 19752656
DA 2026-07-24
ER
PT J
AU Ferreira, MC
   de Carvalho, VF
   Kamamoto, F
   Tuma, P
   Paggiaro, AO
AF Ferreira, Marcus Castro
   de Carvalho, Viviane Fernandes
   Kamamoto, Fabio
   Tuma Junior, Paulo
   Paggiaro, Andre Oliveira
TI Negative pressure therapy (vacuum) for wound bed preparation among
   diabetic patients: case series
SO SAO PAULO MEDICAL JOURNAL
LA English
DT Article
DE Diabetic foot; Skin transplantation; Surgical flaps; Negative-pressure
   wound therapy; Wound healing
ID ASSISTED CLOSURE; RISK-FACTORS; FOOT ULCERS; PREVALENCE; MANAGEMENT;
   NEUROPATHY; LIMB
AB CONTEXT: Complications from diabetes mellitus affecting the lower limbs occur in 40 to 70% of such patients. Neuropathy is the main cause of ulceration and may be associated with vascular impairment. The wound evolves with necrosis and infection, and if not properly treated, amputation may be the end result. Surgical treatment is preferred in complex wounds without spontaneous healing. After debridement of the necrotic tissue, the wound bed needs to be prepared to receive a transplant of either a graft or a flap. Dressings can be used to prepare the wound bed, but this usually leads to longer duration of hospitalization. Negative pressure using a vacuum system has been proposed for speeding up the treatment. This paper had the objective of analyzing the effects of this therapy on wound bed preparation among diabetic patients.
   CASE SERIES: Eighty-four diabetic patients with wounds in their lower limbs were studied. A commercially available vacuum system was used for all patients after adequate debridement of necrotic tissues. For 65 patients, skin grafts completed the treatment and for the other 19, skin flaps were used. Wound bed preparation was achieved over an average time of 7.51 days for 65 patients and 10 days for 12 patients, and in only one case was not achieved.
   CONCLUSIONS: This experience suggests that negative pressure therapy may have an important role in wound bed preparation and as part of the treatment for wounds in the lower limbs of diabetic patients.
C1 [Ferreira, Marcus Castro; Paggiaro, Andre Oliveira] Univ Sao Paulo, Fac Med, Div Plast Surg, Sao Paulo, Brazil.
   [Kamamoto, Fabio] Univ Sao Paulo, Fac Med, Hosp Clin, Univ Hosp, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Ferreira, MC (通讯作者)，Rua Barata Ribeiro 483,Conj 161 & 162,Bela Vista, BR-01308000 Sao Paulo, Brazil.
EM mferrei@uol.com.br
RI Paggiaro, Andr�/F-1570-2016; Carvalho, Viviane/H-9511-2013
OI Carvalho, Viviane/0000-0002-0807-0586
CR Abbott CA, 2002, DIABETIC MED, V19, P377, DOI 10.1046/j.1464-5491.2002.00698.x
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Schultz GS, 2003, WOUND REPAIR REGEN, V11, pS1, DOI 10.1046/j.1524-475X.11.s2.1.x
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   Wada Alexandre, 2006, Sao Paulo Med. J., V124, P150
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Yager DR, 1999, WOUND REPAIR REGEN, V7, P433, DOI 10.1046/j.1524-475X.1999.00433.x
NR 27
TC 12
Z9 17
U1 2
U2 16
PU ASSOCIACAO PAULISTA MEDICINA
PI SAO PAULO
PA AV BRIG LUIS ANTONIO, 278-7 ANDAR, SAO PAULO, CEP01318-901, BRAZIL
SN 1516-3180
J9 SAO PAULO MED J
JI Sao Paulo Med. J.
PD MAY 7
PY 2009
VL 127
IS 3
BP 166
EP 170
DI 10.1590/S1516-31802009000300010
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 505IH
UT WOS:000270685700010
PM 19820878
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Dzieciuchowicz, L
   Espinosa, G
   Grochowicz, L
AF Dzieciuchowicz, Lukasz
   Espinosa, Gaudencio
   Grochowicz, Lukasz
TI Vacuum assisted closure (VAC) in the treatment of advanced diabetic foot
SO CIRUGIA ESPANOLA
LA Spanish
DT Article
DE Diabetic foot; Vacuum assisted closure; Debridement
ID RANDOMIZED CONTROLLED-TRIAL; PRESSURE WOUND THERAPY; MULTICENTER;
   EXPERIENCE; AMPUTATION
AB Introduction: Deep diabetic foot lesions pose an enormous therapeutic problem. The purpose of this study was to present the experience of the use of vacuum assisted closure (VAC) in the treatment of advanced and complicated diabetic foot lesions.
   Material and methods: Five cases of advanced diabetic foot that were treated with VAC were prospectively studied. Three patients were diagnosed with renal failure, including one with renal transplant, who were receiving immunosuppression therapy. Four patients had undergone local foot surgery. The foot lesions were classified as grade 3 or 4 according to the Wagner classification. In all patients extensive debridement was performed that resulted in open minor amputations in four cases and resection of the metatarsophalangeal joint in one case. The VAC was applied during the same procedure. The median follow-up period of the patients was 9 months.
   Results: Foot salvage was achieved in all cases. The median number of changes of VAC was 16 within median period of 8 weeks. Half of the changes were performed as an outpatient procedure. There were no major complications or clinical signs of infection observed. in one case before treatment with VAC began, angioplasty of the iliac artery and superficial femoral artery was performed. Other interventions carried out after the treatment was started were, two distal revascularizations and two partial transmetatarsal amputations.
   Conclusions: VAC appears to be very useful in the treatment of advanced diabetic foot lesions. (C) 2008 AEC. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Dzieciuchowicz, Lukasz; Espinosa, Gaudencio; Grochowicz, Lukasz] Univ Navarra Clin, Pamplona, Spain.
C3 University of Navarra
RP Dzieciuchowicz, L (通讯作者)，Univ Navarra Clin, Pamplona, Spain.
EM ldzieciuchow@unav.es
RI Dzieciuchowicz, Łukasz/GZA-8667-2022
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
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   US Department of Health and Human Services, 1997, DIAB SURV
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   Wagner F W Jr, 1981, Foot Ankle, V2, P64
NR 13
TC 5
Z9 8
U1 0
U2 7
PU ELSEVIER DOYMA SL
PI BARCELONA
PA TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN
SN 0009-739X
J9 CIR ESPAN
JI Cir. Espan.
PD OCT
PY 2009
VL 86
IS 4
BP 213
EP 218
DI 10.1016/j.ciresp.2009.06.003
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 505OV
UT WOS:000270704600004
PM 19683224
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Canavese, F
   Krajbich, JI
   Kuang, AA
AF Canavese, Federico
   Krajbich, Joseph I.
   Kuang, Anna A.
TI Application of the vacuum-assisted closure in pediatric patients with
   orthopedic sequelae of meningococcemia: report of a case successfully
   treated
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
LA English
DT Article
DE meningococcemia; soft tissue loss; vacuum-assisted closure therapy;
   wound healing
ID WOUND MANAGEMENT; SOFT; EXPERIENCE; SEPTICEMIA
AB Patients who survive the initial acute phase of fulminant meningococcemia are at an increased risk for serious complications as a result of poor tissue perfusion. It is rare that early surgical intervention is required, as it is relatively difficult to determine the degree of tissue loss early on. Once the patient is stable, debridement of all necrotic tissue is essential and may necessitate extensive removal of skin, subcutaneous tissue, and muscle. Widespread use of the vacuum-assisted closure for complex soft tissue injuries has generally showed accelerated wound healing compared with traditional methods. We report a new possible application of the vacuum-assisted closure system in very young patients with loss of tissue as a result of purpura fulminans secondary to meningococcemia. J Pediatr Orthop B 18:388-391 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Canavese, Federico; Krajbich, Joseph I.; Kuang, Anna A.] Shriners Hosp Crippled Children, Portland, OR 97239 USA.
RP Canavese, F (通讯作者)，Shriners Hosp Crippled Children, 3101 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM canavese_federico@yahoo.fr
OI CANAVESE, Federico/0000-0002-6114-5372
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bache CE, 2006, J PEDIATR ORTHOPED, V26, P135, DOI 10.1097/01.bpo.0000187991.71645.e7
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   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
   Canavese F, 2008, J BONE JOINT SURG BR, V90B, P377, DOI 10.1302/0301-620X.90B3.19890
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   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Muangman P, 2006, ANN PLAS SURG, V57, P199, DOI 10.1097/01.sap.0000218636.61803.d6
   O'Connor J, 2005, ANN THORAC SURG, V79, P1196, DOI 10.1016/j.athoracsur.2004.09.041
   Penington AJ, 2007, ANN PLAS SURG, V58, P308, DOI 10.1097/01.sap.0000237642.46000.e6
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NR 16
TC 4
Z9 5
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1060-152X
J9 J PEDIATR ORTHOP B
JI J. Pediatr. Orthop.-Part B
PD NOV
PY 2009
VL 18
IS 6
BP 388
EP 391
DI 10.1097/BPB.0b013e32832d83c9
PG 4
WC Orthopedics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Pediatrics
GA 506HI
UT WOS:000270765400022
PM 19620896
DA 2026-07-24
ER
PT J
AU Khashram, M
   Roake, JA
   Lewis, DR
AF Khashram, Manar
   Roake, Justin A.
   Lewis, David R.
TI The Effect of Vacuum-assisted Closure on the Tissue Oxygenation of
   Venous Ulcers: A Pilot Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID TENSION; DISEASE; INSUFFICIENCY; COMPRESSION; ULCERATION; LIMBS; SKIN
AB Background. Vacuum-assisted closure (V.A.C.(R) Therapy, KCI, San Antonio, TX) has been widely used to increase the healing rate of a variety of wounds. It has been hypothesized that one of the actions of VAC is to increase perfusion and subsequent oxygenation of tissue, The aim of the present study was to investigate the effect of VAC therapy on transcutaneous oximetry measurements (TCOM) of skin surrounding chronic venous ulcers, Methods. This was a prospective, experimental pilot study. Patients undergoing compression therapy were recruited from a community wound clinic. All patients had ankle-brachial pressure indices (ABPI) > 0.8. Three TCOM values were taken from around the ulcer and a reference TCOM was taken from the chest. Negative pressure was applied on the ulcer at 125-mmHg continuous subatmospheric pressure and four-layer compression bandaging over the VAC drapes. The duration of the study was 6 days. On day 6, dressings were removed and TCOM was repeated at the same skin sites. Results. Fourteen of the 17 patients completed the trial. The median age was 73 years (range 49-85). No significant difference was found in oxygen partial pressure pre-and post-VAC therapy around the ulcer site (mean 41.5 mmHg versus 40 mmHg [P = 0.671). There was a significant. difference in TCOM between the reference point and the periwound. area (mean 60.5 versus 40 [P < 0.0005]). Conclusion. This pilot study suggest that VAC therapy does not change oxygen partial pressure around venous ulcers. TCOM of the skin around ulcers were low despite normal ABPIs.
C1 [Khashram, Manar; Roake, Justin A.; Lewis, David R.] Univ Otago, Christchurch Sch Med, Dept Vasc Endovasc & Transplant Surg, Christchurch 8140, New Zealand.
C3 University of Otago
RP Khashram, M (通讯作者)，Univ Otago, Christchurch Sch Med, Dept Vasc Endovasc & Transplant Surg, POB 4345, Christchurch 8140, New Zealand.
EM manar.khashram@gmail.com
RI Khashram, Manar/H-7373-2019
OI Khashram, Manar/0000-0003-4921-8433
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NR 27
TC 3
Z9 3
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2009
VL 21
IS 9
BP 249
EP 253
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 507GB
UT WOS:000270839000006
PM 25903816
DA 2026-07-24
ER
PT J
AU Sumpio, BE
   Driver, VR
   Gibbons, GW
   Holloway, GA
   Joseph, WS
   Lavery, LA
   McGuigan, FX
   Steinberg, J
   Andersen, CA
   Blume, P
   Attinger, CE
AF Sumpio, Bauer E.
   Driver, Vickie R.
   Gibbons, Gary W.
   Holloway, G. Allen
   Joseph, Warren S.
   Lavery, Lawrence A.
   McGuigan, Francis X.
   Steinberg, John
   Andersen, Charles A.
   Blume, Peter
   Attinger, Christopher. E.
TI A Multidisciplinary Approach to Limb Preservation: The Role of VAC®
   Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
ID VACUUM-ASSISTED-CLOSURE; PRESSURE WOUND THERAPY; DIABETIC FOOT ULCERS;
   SECURING SKIN-GRAFTS; HEALTH-CARE COSTS; BED PREPARATION; AMPUTATION
   PREVENTION; BACTERIAL BIOBURDEN; RANDOMIZED-TRIAL; PREVALENCE
AB Many factors and conditions, including trauma, vascular insufficiency, and diabetes mellitus, can lead to all amputation of the lower extremity A panel of experts convened to discuss their clinical experiences achieving limb preservation through a multidisciplinary, coordinated plan of care comprising peripheral revascularization, serial debridement, infection control, wound management, wound coverage, and correction of biomechanical abnormalities. Negative pressure wound therapy utilizing reticulated open cell foam (NPWT/ROCF) as delivered by Vacuum Assisted Closure (R) (V.A.C (R). Therapy, KCI Licensing, Inc., San Antonio, TX) is used in conjunction with various surgical techniques and specialized treatment adjuncts to manage acute and chronic wounds. The purpose of this supplement is to present a multidisciplinary approach to limb preservation that employs the use of NPWT/ROCF as an integral part of a treatment algorithm. A cost analysis is also provided as part of the manuscript.
C1 [Attinger, Christopher. E.] Georgetown Univ Hosp, Georgetown Limb Ctr, Washington, DC 20007 USA.
   [Steinberg, John] Georgetown Univ, Sch Med, Dept Plast Surg, Washington, DC 20057 USA.
   [Sumpio, Bauer E.] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06520 USA.
   [Blume, Peter] Yale Univ, Sch Med, Dept Orthopaed, Sect Podiatr Surg, New Haven, CT 06520 USA.
   [Gibbons, Gary W.] Boston Univ, Sch Med, Quincy Med Ctr, Boston, MA 02215 USA.
   [Driver, Vickie R.] Boston Med Univ, Dept Surg, Endovasc & Vasc Serv, Boston, MA USA.
   [Joseph, Warren S.] Roxborough Mem Hosp, Dept Podiatr Surg, Vet Adm Med Ctr, Coatesville, PA USA.
   [Holloway, G. Allen] Maricopa Cty Gen Hosp, Dept Surg, Arizona Burn Ctr, Phoenix, AZ USA.
   [Andersen, Charles A.] Madigan Army Med Ctr, Wound Care Clin, Tacoma, WA USA.
C3 Georgetown University; Georgetown University; Yale University; Yale
   University; Boston University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Maricopa County General Hospital;
   Madigan Army Medical Center
RP Attinger, CE (通讯作者)，Georgetown Univ Hosp, Georgetown Limb Ctr, 1 Main W,3800 Reservoir Rd, Washington, DC 20007 USA.
EM cattinger@aol.com
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NR 105
TC 5
Z9 5
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2009
SU S
BP 3
EP 18
PG 16
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 507GE
UT WOS:000270839300001
DA 2026-07-24
ER
PT J
AU Owen, LJ
   Hotston-Moore, A
   Holt, PE
AF Owen, L. J.
   Hotston-Moore, A.
   Holt, P. E.
TI Vacuum-assisted wound closure following urine-induced skin and thigh
   muscle necrosis in a cat
SO VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
LA English
DT Article
DE Vacuum-assisted closure; wound; cat; urethral rupture; urine necrosis
ID URETHRAL RUPTURE; NEGATIVE-PRESSURE; THERAPY; MANAGEMENT; TRIAL
AB Vacuum-assisted closure (VAC) is a relatively new technique for wound management in dogs and cats. It was successfully used in this cat to treat severe urine-induced skin and thigh muscle necrosis, resulting from a traumatic urethral rupture. No complications were encountered with application of the VAC technique and production of a healthy granulation bed, suitable for wound reconstruction, was achieved after only five days of VAC treatment. The marked wound contraction (40.3%) obtained after eight days of treatment, was sufficient to allow closure of the defect using a simple, rotational subdermal plexus flap. This was a safe, effective and efficient treatment for a challenging wound in a difficult anatomical location.
C1 [Owen, L. J.; Hotston-Moore, A.; Holt, P. E.] Univ Bristol, Div Compan Anim Sci, Dept Vet Clin Sci, Bristol, Avon, England.
C3 University of Bristol
RP Owen, LJ (通讯作者)，Univ Cambridge, Dept Vet Med, Madingley Rd, Cambridge CB3 0ES, England.
EM lo247@cam.ac.uk
OI Hotston Moore, Alasdair/0000-0001-5404-7283
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NR 19
TC 35
Z9 39
U1 0
U2 10
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0932-0814
EI 2567-6911
J9 VET COMP ORTHOPAED
JI Vet. Comp. Orthop. Traumatol.
PY 2009
VL 22
IS 5
BP 417
EP 421
DI 10.3415/VCOT-08-12-0123
PG 5
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA 507TX
UT WOS:000270879100013
PM 19750293
DA 2026-07-24
ER
PT J
AU Tamhankar, AP
   Ravi, K
   Everitt, NJ
AF Tamhankar, A. P.
   Ravi, K.
   Everitt, N. J.
TI VACCUM ASSISTED CLOSURE® THERAPY IN THE TREATMENT OF MESH INFECTION
   AFTER HERNIA REPAIR
SO SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND
   IRELAND
LA English
DT Article
DE HERNIA; SURGICAL MESH; INFECTION; VACUUM-ASSISTED CLOSURE
ID PROSPECTIVE RANDOMIZED-TRIAL; WOUND THERAPY; INCISIONAL HERNIORRHAPHY;
   GROIN; SURGERY
AB Background: Mesh related infection after prosthetic abdominal wall hernia repair is a difficult clinical problem, particularly in an era of evolving microbial resistance. Commonly advocated treatment for such infection involves complete mesh excision which usually leaves a complicated weak wound. We report the use of VAC therapy for mesh infections that allows mesh preservation leaving a sound wound. Methods: From June 2002 to January 2007, four patients with mesh related infection after abdominal wall hernia repair were treated with VAC therapy. Patients' notes were reviewed to gather clinical details. Results: Mesh infection was evident after a variable period (day three to eight years) following hernia repair. Of the four patients, one had infection with methicillin resistant Staphylococcus aureus (MRSA), while the bacteriological cultures from two confirmed Staphylococcus aureus in one and a mixture of Pseudomonas and enterococcus species in the other. One patient failed to show significant bacterial growth on pus swab culture, having had prior broad-spectrum antibiotic treatment for mesh infection. Three patients had complete mesh preservation and one had partial mesh excision. All patients were treated with VAC therapy, following the drainage of their operation sites, until the visible mesh was covered with granulation (one to seven weeks). No patient had a recurrent hernia after complete wound healing. Conclusion: VAC therapy allows salvage of infected exposed mesh by promoting granulation through the mesh. judicious use of VAC therapy may prevent the need of mesh excision and its wound related complications.
C1 [Tamhankar, A. P.] Chesterfield Royal Hosp, Dept Surg, NHS Fdn Trust, Calow S44 5BL, Chesterfield, England.
RP Tamhankar, AP (通讯作者)，Chesterfield Royal Hosp, Dept Surg, NHS Fdn Trust, Calow S44 5BL, Chesterfield, England.
EM aptamhankar@hotmail.com
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NR 23
TC 13
Z9 16
U1 0
U2 6
PU ROYAL COLLEGE SURGEONS EDINBURGH
PI EDINBURGH
PA NICOLSON ST, EDINBURGH EH8 9DW, SCOTLAND
SN 1479-666X
J9 SURG-J R COLL SURG E
JI Surg. J. R. Coll. Surg. Edinb. Irel.
PD OCT
PY 2009
VL 7
IS 5
BP 316
EP 318
DI 10.1016/S1479-666X(09)80010-3
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 511IL
UT WOS:000271157600010
PM 19848066
DA 2026-07-24
ER
PT J
AU Wong, SL
   Defranzo, AJ
   Morykwas, MJ
   Argenta, LC
AF Wong, S. Lindsey
   Defranzo, Andrew J.
   Morykwas, Michael J.
   Argenta, Louis C.
TI Loxoscelism and Negative Pressure Wound Therapy (Vacuum-Assisted
   Closure): A Clinical Case Series
SO AMERICAN SURGEON
LA English
DT Article
ID RECLUSE SPIDER ENVENOMATION; DAPSONE; BITES
AB Brown recluse spider (Loxosceles sp) bites continue to be a significant challenge to manage clinically. Sequelae from these lesions range from chronic necrotic ulcers that persist for months to an acute life-threatening course of sepsis. Negative pressure wound therapy using vacuum-assisted closure (VAC) has been described for use in both acute and chronic wounds. We present a novel application for the use of this therapy in a retrospective review of eight clinical cases treated with the VAC.
C1 [Wong, S. Lindsey; Defranzo, Andrew J.; Morykwas, Michael J.; Argenta, Louis C.] Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM mmorykwa@wfubmc.edu
OI Morykwas, Michael/0009-0001-5547-5172
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NR 16
TC 1
Z9 8
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD NOV
PY 2009
VL 75
IS 11
BP 1128
EP 1131
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 513PZ
UT WOS:000271336600021
PM 19927520
DA 2026-07-24
ER
PT J
AU Vargo, D
   Richardson, JD
   Campbell, A
   Chang, M
   Fabian, T
   Franz, M
   Kaplan, M
   Moore, F
   Reed, RL
   Scott, B
   Silverman, R
AF Vargo, Daniel
   Richardson, J. David
   Campbell, Andre
   Chang, Michael
   Fabian, Timothy
   Franz, Michael
   Kaplan, Mark
   Moore, Frederick
   Reed, R. Lawrence
   Scott, Bradford
   Silverman, Ronald
CA Open Abdomen Advisory Panel
TI Management of the Open Abdomen: From Initial Operation to Definitive
   Closure
SO AMERICAN SURGEON
LA English
DT Review
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; ACELLULAR
   DERMAL MATRIX; MULTIPLE ORGAN FAILURE; FLUID RESUSCITATION STRATEGIES;
   LONG-TERM COMPLICATIONS; DAMAGE-CONTROL; FASCIAL CLOSURE; TRAUMA
   PATIENTS; WITTMANN PATCH
AB The open abdomen is a relatively new and increasingly common strategy for the management of abdominal emergencies in both trauma and general surgery. The use of an abbreviated laparotomy can reduce mortality associated with conditions such as abdominal compartment syndrome; however, the resulting open abdomen is a complex clinical problem. Modern techniques and technologies are now available that allow for improved management of the open abdomen and the progressive reduction of the fascial defect. Indeed, recent evidence indicates that a large proportion of patients treated with open abdomen can now be closed within the initial hospitalization. These techniques and technologies include the appropriate use of negative pressure therapy and synthetic or biologic repair materials. It is essential that general and trauma surgeons understand the core principles underlying the need for and management of the open abdomen. Toward this goal, an Open Abdomen Advisory Panel was established to identify core principles in the management of the open abdomen and to develop a set of recommendations based on the best available evidence. This review presents the principles and recommendations identified by the Open Abdomen Advisory Panel and provides brief case studies for the illustration of these concepts.
C1 [Richardson, J. David] Univ Louisville, Dept Surg, Louisville, KY 40202 USA.
C3 University of Louisville
RP Richardson, JD (通讯作者)，Univ Louisville, Dept Surg, 550 S Jackson St, Louisville, KY 40202 USA.
EM Jdrich01@louisville.edu
RI /AAJ-2575-2020; Silverman, Ronald/A-5155-2018; Chang,
   Michael/JXN-0401-2024
FU Kinetic Concepts, Inc., San Antonio, TX
FX Funding for the Open Abdomen Advisory Panel, editorial assistance and
   manuscript preparation was provided by the Wound Healing and LifeCell
   divisions of Kinetic Concepts, Inc., San Antonio, TX. Editorial support
   was provided by Medisys Health Communications, High Bridge, NJ. Writing
   assistance was provided by Joshua Kilbridge of Kilbridge Associates, San
   Francisco, CA.
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NR 110
TC 112
Z9 118
U1 0
U2 9
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD NOV
PY 2009
VL 75
IS 11
SU S
BP S1
EP S22
PG 22
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 513QA
UT WOS:000271336700001
PM 19998714
DA 2026-07-24
ER
PT J
AU Eyileten, Z
   Akar, AR
   Eryilmaz, S
   Sirlak, M
   Yazicioglu, L
   Durdu, S
   Uysalel, A
   Ozyurda, U
AF Eyileten, Zeynep
   Akar, Ahmet Ruchan
   Eryilmaz, Sadik
   Sirlak, Mustafa
   Yazicioglu, Levent
   Durdu, Serkan
   Uysalel, Adnan
   Ozyurda, Umit
TI Vacuum-assisted closure and bilateral pectoralis muscle flaps for
   different stages of mediastinitis after cardiac surgery
SO SURGERY TODAY
LA English
DT Article
DE Sternotomy; Dehiscence; Deep sternal wound infection; Mediastinitis;
   Complications
ID STERNAL WOUND-INFECTION; POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS;
   SITE INFECTION; MANAGEMENT; MORTALITY; THERAPY; CLASSIFICATION;
   COMPLICATIONS; STERNOTOMY
AB To assess the results of bilateral pectoralis major muscle flaps (BPMMF) and vacuum-assisted closure (VAC) at different stages of postcardiac surgery mediastinitis.
   Of 65 patients with a deep sternal wound infection (DSWI) after cardiac surgery, 33 with a stable sternum were treated with VAC (59.3 +/- 11.7 years of age) and 32 with an unstable sternum or osteomyelitis (63.3 +/- 9.8 years of age) were treated with early BPMMF and continuous irrigation. Delayed BPMMF reconstruction was necessary in six VAC patients.
   The overall incidence of DSWI was 1.04% within the study period. Deep sternal wound infection was diagnosed 15.9 +/- 10.8 days (range 5-62 days) after surgery. Diabetes was more common in the BPMMF group than in the VAC group (P = 0.046). Hospital mortality after treatment was 4.6% (n = 3) overall. Causes of death were septic multiorgan failure and respiratory failure. The infective pathogens were methicillin-resistant Staphylococcus aureus (MRSA; n = 2) and Acinetobacter species (n = 1). The median hospital stay was 29 days (range 15-110 days). After 6 months, only one recurrent sternal infection had occurred in the VAC group.
   Early BPMMF is an effective surgical treatment for DSWI in patients with an unstable sternum and osteomyelitis. VAC may be considered for patients without osteomyelitis but a stable sternum, or as adjuvant therapy in patients with comorbidity.
C1 [Eyileten, Zeynep; Akar, Ahmet Ruchan; Eryilmaz, Sadik; Sirlak, Mustafa; Yazicioglu, Levent; Durdu, Serkan; Uysalel, Adnan; Ozyurda, Umit] Ankara Univ, Sch Med, Ctr Heart, Dept Cardiovasc Surg, TR-06340 Ankara, Turkey.
C3 Ankara University
RP Akar, AR (通讯作者)，Ankara Univ, Sch Med, Ctr Heart, Dept Cardiovasc Surg, TR-06340 Ankara, Turkey.
RI ; Akar, Ahmet Rüçhan/C-9905-2009; Şırlak, Mustafa/ABI-7443-2020
OI Durdu, Serkan/0000-0002-0578-1657; Şırlak, Mustafa/0000-0001-6806-7672
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NR 26
TC 26
Z9 29
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD NOV
PY 2009
VL 39
IS 11
BP 947
EP 954
DI 10.1007/s00595-008-3982-5
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 514UA
UT WOS:000271419900005
PM 19882316
DA 2026-07-24
ER
PT J
AU Scherer, SS
   Pietramaggiori, G
   Mathews, JC
   Orgill, DP
AF Scherer, Sandra Saja
   Pietramaggiori, Giorgio
   Mathews, Jasmine C.
   Orgill, Dennis P.
TI Short Periodic Applications of the Vacuum-Assisted Closure Device Cause
   an Extended Tissue Response in the Diabetic Mouse Model
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID SUBATMOSPHERIC PRESSURE; CLINICAL-EXPERIENCE; CHRONIC WOUNDS;
   ANGIOGENESIS; THERAPY; SWINE
AB Background: The vacuum-assisted closure device is a widely used mechanical modulator of wound healing; however, the optimal time kinetics of application have not been determined. The objective of the study was to optimize the kinetics of vacuum-assisted closure application.
   Methods: Full-thickness wounds in seven diabetic mice per study group were treated with either an occlusive dressing alone, the vacuum-assisted closure device for 6 or 12 hours, or the vacuum-assisted closure device periodically for 4 hours every other day or continuously for 7 days. Wound closure and tissue response were evaluated by macroscopic, histologic, and immunohistochemical analyses on day 7.
   Results: Wound closure was significantly faster after short initial vacuum-assisted closure (6-hour and 12-hour groups) when compared with continuous treatment. Increased granulation tissue formation was seen in the 12-hour group (2.4-fold increase) and in those treated periodically for 4 hours every other day (3.2-fold increase) compared with the dressing-alone controls. Significant stimulation of cell proliferation was seen after all vacuum-assisted closure patterns (3.6- to 5.3-fold increase), whereas angiogenesis was augmented only after the device was applied for either three times for 4 hours (4.3-fold) or continuously (4.7-fold) when compared with dressing-treated wounds. Treatment three times for 4 hours showed a superior angiogenic effect also when compared with short initial applications (6-hour and 12-hour groups).
   Conclusions: Short vacuum-assisted closure treatment induced an extended biological response in the wound. A total of 12 hours of periodically applied vacuum-assisted closure reached a similar wound tissue response as continuously applied vacuum-assisted closure for 7 days. These findings suggest new clinical approaches for mechanical wound-healing devices. (Plast. Reconstr. Surg. 124: 1458, 2009.)
C1 [Orgill, Dennis P.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
   Univ Hosp Geneva, Dept Surg, Geneva, Switzerland.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; University of Geneva
RP Orgill, DP (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI PIETRAMAGGIORI, Giorgio/HJA-1920-2022; Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
CR Ahroni JH, 1999, DIABETES CARE, V22, P965, DOI 10.2337/diacare.22.6.965
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Chen CS, 1997, SCIENCE, V276, P1425, DOI 10.1126/science.276.5317.1425
   Fabian TS, 2000, AM SURGEON, V66, P1136
   Greene AK, 2006, ANN PLAS SURG, V56, P418, DOI 10.1097/01.sap.0000202831.43294.02
   Huang S, 1999, NAT CELL BIOL, V1, pE131, DOI 10.1038/13043
   Ingber DE, 1995, J BIOMECH, V28, P1471, DOI 10.1016/0021-9290(95)00095-X
   Kilpadi D, 2006, WOUND REPAIR REGEN, V14, P210, DOI 10.1111/j.1743-6109.2006.00112.x
   Kyriakides TR, 1999, P NATL ACAD SCI USA, V96, P4449, DOI 10.1073/pnas.96.8.4449
   MARKS MW, 1987, CLIN PLAST SURG, V14, P455
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Orgill DP, 2004, WOUNDS, p15S
   Pietramaggiori G, 2007, ANN SURG, V246, P896, DOI 10.1097/SLA.0b013e3180caa47f
   Pietramaggiori G, 2007, WOUND REPAIR REGEN, V15, P213, DOI 10.1111/j.1524-475X.2007.00207.x
   Pietramaggiori G, 2006, WOUND REPAIR REGEN, V14, P573, DOI 10.1111/j.1743-6109.2006.00164.x
   Ramsey SD, 1999, DIABETES CARE, V22, P382, DOI 10.2337/diacare.22.3.382
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
   Scherer SS, 2008, WOUNDS, V20, P18
   Zheng W, 2008, AM J PHYSIOL-HEART C, V295, pH794, DOI 10.1152/ajpheart.00343.2008
NR 23
TC 36
Z9 43
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2009
VL 124
IS 5
BP 1458
EP 1465
DI 10.1097/PRS.0b013e3181bbc829
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 515ZZ
UT WOS:000271512700012
PM 20009831
DA 2026-07-24
ER
PT J
AU Oeltjen, JC
   Panos, AL
   Salerno, TA
   Ricci, M
AF Oeltjen, John C.
   Panos, Anthony L.
   Salerno, Tomas A.
   Ricci, Marco
TI Complete Vacuum-Assisted Sternal Closure Following Neonatal Cardiac
   Surgery
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID MEDIASTINITIS
AB P>Vacuum-assisted closure (VAC) has been used with success in the management of adults and children with sternal infections. However, this technique has not been applied previously to neonates requiring delayed sternal closure as the sole modality of therapy. In this article, we describe the management of two newborns with hypoplastic left heart syndrome in whom complete sternal wound healing was accomplished solely by using the VAC system. The implications of this new modality of treatment are discussed.
   (J Card Surg 2009;24:748-750).
C1 [Ricci, Marco] Univ Miami, Miller Sch Med, Jackson Mem Hosp, Holtz Childrens Hosp,Div Cardiothorac Surg & Plas, Miami, FL 33136 USA.
   Univ Miami, Miller Sch Med, Div Cardiothorac Surg & Plast Surg, Miami, FL 33136 USA.
C3 University of Miami; University of Miami
RP Ricci, M (通讯作者)，Univ Miami, Miller Sch Med, Jackson Mem Hosp, Holtz Childrens Hosp,Div Cardiothorac Surg & Plas, POB 016960 R-114, Miami, FL 33136 USA.
EM mricci@med.miami.edu
RI Ricci, Marco/PRQ-7845-2026; Ricci, Marco/KIG-7617-2024
OI Ricci, Marco/0000-0001-6816-4894; Panos, Anthony/0000-0002-4208-1908
CR Fleck Tatjana, 2006, Interact Cardiovasc Thorac Surg, V5, P285, DOI 10.1510/icvts.2005.122424
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   Kadohama T, 2008, ANN THORAC SURG, V85, P1094, DOI 10.1016/j.athoracsur.2007.09.004
   Luckraz H, 2003, J THORAC CARDIOV SUR, V125, P301, DOI 10.1067/mtc.2003.74
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Salazard B, 2008, J PLAST RECONSTR AES, V61, P302, DOI 10.1016/j.bjps.2007.05.004
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Vicchio M, 2007, J THORAC CARDIOV SUR, V134, P254, DOI 10.1016/j.jtcvs.2007.03.024
NR 8
TC 3
Z9 3
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD NOV
PY 2009
VL 24
IS 6
BP 748
EP 750
DI 10.1111/j.1540-8191.2009.00902.x
PG 3
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 516EB
UT WOS:000271523400036
PM 19765169
DA 2026-07-24
ER
PT J
AU Wu, MH
   Wu, HY
AF Wu, Ming-Ho
   Wu, Han-Yun
TI A Simple Device for Closure of a Colocutaneous Fistula within the
   Laparotomy Wound: A Case Report
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE colocutaneous fistula; esophageal carcinoma; esophageal reconstruction;
   laparotomy wound; nonsurgical management
ID ENTEROCUTANEOUS FISTULAS; OPEN ABDOMEN; MANAGEMENT
AB Colocutaneous fistulas within laparotomy wounds are rare and difficult to treat. Surgical repair may be contraindicated or not desired and negative pressure wound therapy may not be successful. A simple device made from a silicone, flexi-aid hand exerciser was used to close a colocutaneous fistula within the laparotomy wound of a 50-year old man following surgery of an esophageal carcinoma and a surgical history of Whipple's procedure for adenocarcinoma of the ampulla of Vater. His wound developed 9 days postoperatively, measured 8 cm x 3 cm x 2 cm, and was contaminated with fecal material. Initial efforts involving cleansing and the use of negative pressure wound therapy were unsuccessful and the patient refused additional surgery. In this patient, a silicone occlusion device, used in conjunction with a silver hydrofiber dressing, prevented fecal soiling and facilitated closure of the colocutaneous fistula and the laparotomy wound. He was discharged on postop day 22 and healed by postop day 64. This was the first time this approach was used. Studies to optimize nonsurgical management approaches of these complicated conditions are needed.
C1 [Wu, Ming-Ho; Wu, Han-Yun] Tainan Municipal Hosp, Dept Surg, Div Thorac Surg, Tainan, Taiwan.
RP Wu, MH (通讯作者)，670 Chung Te Rd, Tainan 701, Taiwan.
EM m2201@mail.ncku.edu.tw
CR Goverman J, 2006, J TRAUMA, V60, P428, DOI 10.1097/01.ta.0000203588.66012.c4
   Kumar R, 2007, SURG LAPARO ENDO PER, V17, P447, DOI 10.1097/SLE.0b013e3180dc9392
   Lansdown A B G, 2005, J Wound Care, V14, P155
   Lynch AC, 2004, ANN SURG, V240, P825, DOI 10.1097/01.sla.0000143895.17811.e3
   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
   Reed T, 2006, OSTOMY WOUND MANAG, V52, P60
   STREZA GA, 1977, AM J SURG, V134, P772, DOI 10.1016/0002-9610(77)90322-1
   Tachi M, 2002, ANN PLAS SURG, V48, P554, DOI 10.1097/00000637-200205000-00019
   WEERD LD, 2007, ANN PLAST SURG, V58, P580
   Wu MH, 2001, EUR J CARDIO-THORAC, V19, P400, DOI 10.1016/S1010-7940(01)00614-5
NR 10
TC 0
Z9 0
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD OCT
PY 2009
VL 55
IS 10
BP 24
EP 26
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 517IN
UT WOS:000271606800007
PM 19864693
DA 2026-07-24
ER
PT J
AU Gerszberg, KS
   Tan, V
AF Gerszberg, Kenneth S.
   Tan, Virak
TI Vacuum-Assisted Closure With External Fixation of the Hand
SO ORTHOPEDICS
LA English
DT Article
ID THERAPY
AB This article demonstrates an easy technique for applying a vacuum-assisted closure around an external fixator of the wrist and hand, with the aid of a surgical glove.
C1 [Gerszberg, Kenneth S.; Tan, Virak] Univ Med & Dent New Jersey, Dept Orthoped, New Jersey Med Sch, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Tan, V (通讯作者)，Univ Med & Dent New Jersey, Dept Orthoped, New Jersey Med Sch, 140 Bergen St,ACC S,D Level Orthoped, Newark, NJ 07103 USA.
EM tanvi@umdnj.edu
CR DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   *KIN CONC INC, 2007, VAC THER SAF INF
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   Lemmon JA, 2008, PLAST RECONSTR SURG, V121, p234E, DOI 10.1097/01.prs.0000305394.80769.8b
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Ng R, 2006, J PLAST RECONSTR AES, V59, P1011, DOI 10.1016/j.bjps.2006.02.002
   Ozer K, 2006, ANN PLAS SURG, V56, P693, DOI 10.1097/01.sap.0000203997.70550.f8
NR 7
TC 3
Z9 3
U1 0
U2 3
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD NOV
PY 2009
VL 32
IS 11
BP 829
EP 831
DI 10.3928/01477447-20090922-16
PG 3
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 520YZ
UT WOS:000271887100004
PM 19902885
DA 2026-07-24
ER
PT J
AU Nishimura, K
   Kanaoka, Y
   Ishiguro, S
   Harada, S
   Shiraya, S
   Fujiwara, Y
   Nakamura, Y
   Kamihira, S
   Nishimura, M
AF Nishimura, K.
   Kanaoka, Y.
   Ishiguro, S.
   Harada, S.
   Shiraya, S.
   Fujiwara, Y.
   Nakamura, Y.
   Kamihira, S.
   Nishimura, M.
TI Vacuum-assisted closure for bilateral severe ischemic foot after
   revascularization: a case report
SO INTERNATIONAL ANGIOLOGY
LA English
DT Article
DE Negative-pressure wound therapy; Ischemia; Foot
ID WOUND CONTROL
AB Vacuum-assisted closure (VAC) therapy is a unique system that helps promote wound healing. We report a case of severe ischemic foot in which VAC therapy markedly improved wound healing. A 73-year-old man underwent left axillopopliteal bypass and left 3rd, 4th, and 5th digital amputations for gangrene. Although his amputation stumps were complicated with methicillin-resistant Staphylococcus aureus (MRSA) infection, the stumps were successfully healed by VAC. He also had gangrene in his right 1st toe, which could not healed by VAC alone, and we performed right femoropopliteal bypass and right 1st digital amputation. The stump with MRSA infection was also successfully healed by VAC. Histopathologic examination revealed a lot of microvessels in the increased granulation tissue. [Int Angiol 2009;28:340-43]
C1 [Nishimura, K.; Kanaoka, Y.; Ishiguro, S.; Harada, S.; Shiraya, S.; Fujiwara, Y.; Nakamura, Y.; Kamihira, S.; Nishimura, M.] Tottori Univ, Fac Med, Div Organ Regenerat Surg, Yonago, Tottori 6838504, Japan.
C3 Tottori University
RP Nishimura, K (通讯作者)，Tottori Univ, Fac Med, Div Organ Regenerat Surg, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan.
EM nige@grape.med.tottori-u.ac.jp
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Cowan KN, 2005, ANN THORAC SURG, V80, P2205, DOI 10.1016/j.athoracsur.2005.04.005
   HAGA M, 2005, JPN J VASC SURG, V14, P689
   MCCALLON S.K., 2000, Ostomy Wound Manage, V46, P28
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
NR 7
TC 4
Z9 4
U1 0
U2 3
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0392-9590
EI 1827-1839
J9 INT ANGIOL
JI Int. Angiol.
PD AUG
PY 2009
VL 28
IS 4
BP 340
EP 343
PG 4
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 521MM
UT WOS:000271925600014
PM 19648880
DA 2026-07-24
ER
PT J
AU Bemelman, WA
AF Bemelman, W. A.
TI Vacuum assisted closure in coloproctology
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Review
DE Endosponge; Anastomotic leakage; Vacuum
ID TOTAL MESORECTAL EXCISION; ANASTOMOTIC LEAKAGE; RECTAL-CANCER; ANTERIOR
   RESECTION; RISK-FACTORS; SURGERY; IMPACT
AB Vacuum-assisted closure has earned its indications in coloproctology. It has been described with variable results in the treatment of large perineal defects after abdominoperineal excision, in the treatment of stoma dehiscence and perirectal abscesses. The most promising indication for vacuum-assisted closure is probably the treatment of para-anastomotic presacral abscesses following anastomotic leakage after total mesorectal excision. Early initiation of vacuum-assisted closure has the potential to prevent debilitating persistent presacral sinuses precluding stoma closure and bad function of the neorectum. Prompt initiation of endosponge treatment is advised after the anastomotic leakage with the purulent cavity is diagnosed. The endosponge is inserted transanally and connected with a low vacuum bottle. With the gradual reduction in the cavity, the endosponge is reduced in size every 3-4 days when the endosponge is exchanged. It takes 3-6 weeks to close the cavity. Future studies should focus on the stoma closure rate and function to assess whether this intensive postoperative treatment of anastomotic leakages is justified.
C1 Acad Med Ctr, Dept Surg, NL-1100 DE Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam
RP Bemelman, WA (通讯作者)，Acad Med Ctr, Dept Surg, POB 22700, NL-1100 DE Amsterdam, Netherlands.
EM w.a.bemelman@amc.uva.nl
RI Bemelman, Wilhelmus/AAA-1635-2021
CR Arumainayagam N, 2009, COLORECTAL DIS, V11, P288, DOI 10.1111/j.1463-1318.2008.01585.x
   Crick S, 2009, TECH COLOPROCTOL, V13, P181, DOI 10.1007/s10151-009-0477-3
   DEHONDT G, 2009, TECH COLOPROCTOL, V15
   DURAI R, 2009, TECH COLOPROCTOL, V14
   Hallbook O, 1996, BRIT J SURG, V83, P60, DOI 10.1002/bjs.1800830119
   Jung SH, 2008, DIS COLON RECTUM, V51, P902, DOI 10.1007/s10350-008-9272-x
   Lee WS, 2008, WORLD J SURG, V32, P1124, DOI 10.1007/s00268-007-9451-2
   Ptok H, 2007, BRIT J SURG, V94, P1548, DOI 10.1002/bjs.5707
   van Koperen PJ, 2009, SURG ENDOSC, V23, P1379, DOI 10.1007/s00464-008-0186-4
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 10
TC 26
Z9 28
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1123-6337
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD DEC
PY 2009
VL 13
IS 4
BP 261
EP 263
DI 10.1007/s10151-009-0543-x
PG 3
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 521YV
UT WOS:000271963500001
PM 19907919
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU D'Hondt, M
   De Hondt, G
   Malisse, P
   Vanden Boer, J
   Knol, J
AF D'Hondt, Mathieu
   De Hondt, Geert
   Malisse, Paul
   Vanden Boer, Jan
   Knol, Joep
TI Chronic pelvic abscedation after completion proctectomy in an irradiated
   pelvis: another indication for ENDO-sponge treatment?
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE ENDO-sponge (R); Irradiated pelvis; Presacral abscess; Proctectomy
ID VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE; WOUND CONTROL;
   RADIOTHERAPY; RESECTION
AB Six years after completion proctectomy, a patient presented with invalidating pain, fever and massive mucopurulent secretion through the perineal wound after completion proctectomy. CT-scan revealed a large presacral abscess and osteonecrosis of the sacrum. The patient consented to placement of an ENDO-sponge(A (R)) (B. Braun Medical B.V., Melsungen Germany). On day 4 granulation tissue covered the walls of the cavity and the amount of necrotic tissue and fibrin was reduced. The foam was changed every 4 days and treatment was continued for 20 days. On day 20, vacuum assisted closure therapy was stopped and the remnant cavity was further rinsed with saline. There was no more evacuation of mucus or pus. Three months later, the patient was symptom free and only a small perineal dimple remained. ENDO-sponge(A (R)) (B. Braun Medical B.V., Melsungen Germany) treatment is possible for presacral abscedation which is a well-known complication following abdominoperineal rectum amputation.
C1 [D'Hondt, Mathieu; Malisse, Paul; Vanden Boer, Jan; Knol, Joep] Maria Ziekenhuis Noord Limburg, Dept Digest Surg, B-3900 Overpelt, Belgium.
   [De Hondt, Geert] Maria Ziekenhuis Noord Limburg, Dept Internal Med, B-3900 Overpelt, Belgium.
RP D'Hondt, M (通讯作者)，Kleine Leiestr 1, B-8500 Kortrijk, Belgium.
EM mathieudhondt2000@yahoo.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Kapiteijn E, 2001, NEW ENGL J MED, V345, P638, DOI 10.1056/NEJMoa010580
   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nagell CF, 2006, INT J COLORECTAL DIS, V21, P657, DOI 10.1007/s00384-005-0083-4
   Ooi BS, 1999, DIS COLON RECTUM, V42, P403, DOI 10.1007/BF02236362
   PAHLMAN L, 1989, BRIT J SURG, V76, P605, DOI 10.1002/bjs.1800760627
   Weidenhagen R, 2006, ZBL CHIR, V131, pS115, DOI 10.1055/s-2006-921512
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 10
TC 9
Z9 9
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD DEC
PY 2009
VL 13
IS 4
BP 311
EP 314
DI 10.1007/s10151-009-0505-3
PG 4
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 521YV
UT WOS:000271963500011
PM 19603139
DA 2026-07-24
ER
PT J
AU Borgquist, O
   Gustafson, L
   Ingemansson, R
   Malmsjö, M
AF Borgquist, Ola
   Gustafson, Lotta
   Ingemansson, Richard
   Malmsjo, Malin
TI Tissue Ingrowth Into Foam but Not Into Gauze During Negative Pressure
   Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FOUNDATION
AB Background. Foam and gauze are two types of wound fillers used for negative pressure wound therapy (NPWT). Differences in the wound healing effects of foam and gauze have been observed clinically. The aim of the present study was to examine the effects of NPWT on the wound bed using foam and gauze. Methods. A porcine peripheral wound model was treated with NPWT at 0, -75 mmHg, or -125 mmHg for 72 hours. The effects of foam and gauze on the wound bed were compared, and the force required to remove the dressings was measured. Sections of biopsies from the wound bed with an overlying dressing were stained with hematoxylin-eosin and Giemsa and were examined histologically. Results. The force ratio needed to remove the wound filler from the wound bed after treatment with negative pressure was greater for foam than for gauze. NPWT caused the wound bed tissue to grow into the foam, while there was I no such ingrowth into gauze. Furthermore, beneath the foam there was more leukocyte infiltration, tissue disorganization, disruption of contact among cells, and differences in size among cells. The results were similar regardless of the level of negative pressure. Conclusion. More force was required to remove foam compared to gauze following NPWT, which may have been due to greater ingrowth into foam. These findings may explain the patient discomfort and wound bed disruption upon removal of foam. The observed differences in wound bed tissue morphology under foam and gauze are in accordance with the clinically observed differences in quality of granulation tissue formation.
C1 [Borgquist, Ola; Gustafson, Lotta; Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, Lund, Sweden.
   [Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，Lund Univ, Dept Ophthalmol, Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Borgquist, Ola/AAO-6451-2020
OI Maljö, Malin/0000-0001-9849-9599; 
FU Ake-Wieberg Foundation; Magn. Bergvall Foundation; Swedish Medical
   Association; Royal Physiographic Society in Lurid; Swedish Medical
   Research Council; Crafoord Foundation; Swedish Heart-Lung Foundation;
   Swedish Government; Swedish Hypertension Society; Prospera
FX The study was financially supported by the Ake-Wieberg Foundation, the
   Magn. Bergvall Foundation, the Swedish Medical Association, the Royal
   Physiographic Society in Lurid, the Swedish Medical Research Council,
   the Crafoord Foundation, the Swedish Heart-Lung Foundation, the Swedish
   Government Grant for Clinical Research, the Swedish Hypertension
   Society, and Prospera. Dr. Malmsjo received a research grant from
   Prospera.
CR Apostoli Alberto, 2008, Prof Inferm, V61, P158
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P E, 1999, J Wound Care, V8, P79
   Banwell P E, 2003, J Wound Care, V12, P22
   BORGQUIST O, PLAST RECON IN PRESS
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   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Evans D, 2001, BRIT J PLAST SURG, V54, P238, DOI 10.1054/bjps.2001.3547
   Gouttefangeas C, 2001, CLIN EXP IMMUNOL, V124, P398, DOI 10.1046/j.1365-2249.2001.01547.x
   Greene AK, 2006, ANN PLAS SURG, V56, P418, DOI 10.1097/01.sap.0000202831.43294.02
   Kirker KR, 2009, WOUNDS, V21, P229
   Lu X., 2003, Chin J Clin Rehab, V7, P1244
   Luttikhuizen DT, 2006, TISSUE ENG, V12, P1955, DOI 10.1089/ten.2006.12.1955
   MORYKWAS M, 2003, 1 INT TOP NEG PRESS, P39
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   PAGLINAWAN R, 2008, EUR TISS REP SOC M S
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
NR 18
TC 43
Z9 49
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2009
VL 21
IS 11
BP 302
EP 309
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 521ZZ
UT WOS:000271967500004
PM 25902776
DA 2026-07-24
ER
PT J
AU Canda, AE
   Karaca, A
AF Canda, A. E.
   Karaca, A.
TI Incisional hernia in action: the use of vacuum-assisted closure and
   porcine dermal collagen implant
SO HERNIA
LA English
DT Article; Proceedings Paper
CT Congress of the Turkish-Society-of-Surgery
CY 2008
CL Antalya, TURKEY
SP Turkish Soc Surg
DE Hernia repair; Open abdomen; Biologic implant; PDC; CollaMend; VAC
ID ABDOMINAL-WALL DEFECTS; PACK TECHNIQUE; WOUND CONTROL; REPAIR;
   EXPERIENCE; RECONSTRUCTION; MANAGEMENT; MATRIX; SUTURE; TRIAL
AB In this paper, we describe our experience in the successful use of vacuum-assisted closure (VAC) and porcine dermal collagen (PDC) mesh reconstruction of a complicated contaminated abdominal wall defect resulting from a strangulated incisional hernia with late jejunal perforation in a 57-year-old obese and diabetic woman.
C1 [Canda, A. E.; Karaca, A.] Manisa State Hosp, Surg Clin, Manisa, Turkey.
C3 Manisa Merkez Efendi State Hospital; Manisa State Hospital
RP Canda, AE (通讯作者)，217 Sok,23-8 Bornova, TR-35040 Izmir, Turkey.
EM emre.canda@deu.edu.tr
RI Canda, Aras/O-7445-2019; karaca, ahmet serdar/AAK-5337-2021
OI karaca, ahmet serdar/0000-0001-6456-1868
CR Adedeji OA, 2002, BRIT J PLAST SURG, V55, P85, DOI 10.1054/bjps.2001.3711
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Buinewicz B, 2004, ANN PLAS SURG, V52, P188, DOI 10.1097/01.sap.0000100895.41198.27
   Burger JWA, 2004, ANN SURG, V240, P578
   Cassar K, 2002, BRIT J SURG, V89, P534, DOI 10.1046/j.1365-2168.2002.02083.x
   Catena F, 2007, Hernia, V11, P57, DOI 10.1007/s10029-006-0171-6
   DELUSTRO F, 1990, CLIN ORTHOP RELAT R, P263
   den Hartog Dennis, 2008, Cochrane Database Syst Rev, pCD006438, DOI 10.1002/14651858.CD006438.pub2
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   Hsu PW, 2009, J PLAST RECONSTR AES, V62, P1484, DOI 10.1016/j.bjps.2008.04.060
   Kim H, 2006, AM J SURG, V192, P705, DOI 10.1016/j.amjsurg.2006.09.003
   Korenkov M, 2002, BJS-BRIT J SURG, V89, P50, DOI 10.1046/j.0007-1323.2001.01974.x
   Miller PR, 2002, J TRAUMA, V53, P843, DOI 10.1097/00005373-200211000-00007
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Navsaria PH, 2003, BRIT J SURG, V90, P718, DOI 10.1002/bjs.4101
   Ozturk E, 2009, AM J SURG, V197, P660, DOI 10.1016/j.amjsurg.2008.04.018
   Parker David M, 2006, Curr Surg, V63, P255, DOI 10.1016/j.cursur.2006.05.003
   Patton JH, 2007, AM J SURG, V193, P360, DOI 10.1016/j.amjsurg.2006.09.021
   Paul A, 1998, EUR J SURG, V164, P361
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Rao M, 2007, COLORECTAL DIS, V9, P266, DOI 10.1111/j.1463-1318.2006.01154.x
   Saettele T M, 2007, Hernia, V11, P279, DOI 10.1007/s10029-006-0186-z
   Shaikh FM, 2007, WORLD J SURG, V31, P1966, DOI 10.1007/s00268-007-9174-4
   Sokmen S, 2002, Hernia, V6, P124
NR 25
TC 6
Z9 8
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
J9 HERNIA
JI Hernia
PD DEC
PY 2009
VL 13
IS 6
BP 651
EP 655
DI 10.1007/s10029-009-0497-y
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 522EI
UT WOS:000271980200017
PM 19347565
DA 2026-07-24
ER
PT J
AU Steingrímsson, S
   Gustafsson, R
   Gudbjartsson, T
   Mokhtari, A
   Ingemansson, R
   Sjögren, J
AF Steingrimsson, Steinn
   Gustafsson, Ronny
   Gudbjartsson, Tomas
   Mokhtari, Arash
   Ingemansson, Richard
   Sjogren, Johan
TI Sternocutaneous Fistulas After Cardiac Surgery: Incidence and Late
   Outcome During a Ten-Year Follow-Up
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; STERNAL OSTEOMYELITIS; WOUND-INFECTION;
   STERNOTOMY; COMPLICATIONS; MEDIASTINITIS; MANAGEMENT
AB Background. Sternocutaneous fistulas (SCFs) after cardiac surgery represent a complex surgical problem involving multiple hospital admissions, prolonged antibiotic treatment, and repeated debridements. Our objective was to identify the incidence of and risk factors for SCF, and to evaluate long-term survival.
   Methods. A total of 12,297 patients underwent sternotomy for cardiac surgery between January 1999 and December 2008, and 32 patients were diagnosed as having SCF during follow-up. Risk factors were identified with multivariate analysis and survival was compared using the log-rank test.
   Results. The cumulative incidence of SCF at one year was 0.23%. There was no significant difference in mean time from sternal closure after cardiac surgery to intervention for SCF with (n = 9) or without (n = 23) preceding sternal wound infection (SWI); 6.1 +/- 4.2 versus 6.9 +/- 4.6 months, (p = ns). Risk factors for developing SCF were previous SWI (odds ratio [OR] = 15.7), renal failure (OR = 12.5), smoking (OR = 4.7), and use of bone wax during cardiac surgery (OR = 4.2). Negative-pressure wound therapy was applied in 20 cases of extensive SCFs. Five-year survival of SCF patients was 58% +/- 1% as compared with 85% +/- 4% in the control group (p = 0.003).
   Conclusions. Sternocutaneous fistula is a devastating diagnosis with significant morbidity and mortality. Previous SWI, renal failure, smoking, and use of bone wax are major risk factors. However, in a majority of patients SCF is not preceded by SWI and our results indicate that SCF may be a foreign body infection that develops in susceptible patients with risk factors for poor wound healing. Negative-pressure wound therapy may be a valuable adjunct in the treatment of extensive SCF. (Ann Thorac Surg 2009;88:1910-5) (C) 2009 by The Society of Thoracic Surgeons
C1 [Sjogren, Johan] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   Univ Iceland, Fac Med, Landspitali Univ Hosp, Dept Cardiothorac Surg, Reykjavik, Iceland.
C3 Lund University; Skane University Hospital; University of Iceland;
   Landspitali National University Hospital
RP Sjögren, J (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM johan.sjogren@med.lu.se
RI Steingrimsson, Steinn/AAF-5475-2021; Sjögren, Johan/AAZ-6448-2021
OI Steingrimsson, Steinn/0000-0001-8320-5607; Ingemansson,
   Richard/0000-0001-7623-8953; 
CR Darouiche RO, 2004, NEW ENGL J MED, V350, P1422, DOI 10.1056/NEJMra035415
   Falagas Matthew E, 2006, J Infect, V52, pe151, DOI 10.1016/j.jinf.2005.08.007
   HERRERA HR, 1983, BRIT J PLAST SURG, V36, P421, DOI 10.1016/0007-1226(83)90120-0
   JOHNSON P, 1985, ANN THORAC SURG, V40, P69, DOI 10.1016/S0003-4975(10)61173-3
   Jones G, 1997, ANN SURG, V225, P766, DOI 10.1097/00000658-199706000-00014
   PAIROLERO PC, 1991, ANN SURG, V213, P583, DOI 10.1097/00000658-199106000-00008
   Peivandi AA, 2003, CARDIOVASC SURG, V11, P207, DOI 10.1016/S0967-2109(03)00006-1
   Petrikkos G, 2001, MYCOSES, V44, P422, DOI 10.1046/j.1439-0507.2001.00673.x
   Roggenkamp A, 2004, EUR J CLIN MICROBIOL, V23, P419, DOI 10.1007/s10096-004-1124-6
   Schierholz JM, 2001, J HOSP INFECT, V49, P87, DOI 10.1053/jhin.2001.1052
   SIEGMANIGRA Y, 1990, SCAND J INFECT DIS, V22, P633, DOI 10.3109/00365549009027114
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
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   Yuen JC, 1995, ANN PLAS SURG, V35, P585, DOI 10.1097/00000637-199512000-00005
NR 16
TC 29
Z9 30
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD DEC
PY 2009
VL 88
IS 6
BP 1910
EP 1915
DI 10.1016/j.athoracsur.2009.07.012
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 522VV
UT WOS:000272029100028
PM 19932261
DA 2026-07-24
ER
PT J
AU Kouretas, PC
   Burch, PT
   Kaza, AK
   Lambert, LM
   Witte, MK
   Everitt, MD
   Siddiqi, FA
AF Kouretas, Peter C.
   Burch, Phillip T.
   Kaza, Aditya K.
   Lambert, Linda M.
   Witte, Madolin K.
   Everitt, Melanie D.
   Siddiqi, Faizi A.
TI Management of Deep Wound Complications With Vacuum-Assisted Therapy
   After Berlin Heart EXCOR Ventricular Assist Device Placement in the
   Pediatric Population
SO ARTIFICIAL ORGANS
LA English
DT Article
DE Pediatrics; Vacuum-assisted closure; Ventricular assist device; Wound
   complications
ID CLOSURE; INFECTION; SUPPORT
AB Wound complications after ventricular assist device (VAD) placement remain a formidable challenge to surgeons. The Berlin Heart EXCOR VAD is a versatile pulsatile system that has been successful in pediatric patients of all ages and sizes. Prevention of device-related complications such as infection, particularly in pediatric patients, remains an essential issue in minimizing patient morbidity and mortality. The introduction of vacuum-assisted wound closure (VAC) therapy and its application in VAD-related wound complications provide an efficient and effective method for wound healing. We report our experience in the management of deep wound complications in two pediatric patients after placement of the Berlin Heart EXCOR VAD. The wound VAC system proved to achieve complete wound healing without any infectious complications.
C1 [Kouretas, Peter C.; Burch, Phillip T.; Kaza, Aditya K.; Lambert, Linda M.; Siddiqi, Faizi A.] Univ Utah, Primary Childrens Med Ctr, Dept Surg, Salt Lake City, UT USA.
   [Witte, Madolin K.; Everitt, Melanie D.] Univ Utah, Primary Childrens Med Ctr, Dept Pediat, Salt Lake City, UT USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Kouretas, PC (通讯作者)，100 N Mario Capecchi Dr,Suite 2800, Salt Lake City, UT 84113 USA.
EM peter.kouretas@hsc.utah.edu
RI Kaza, Aditya/AAE-2116-2019
OI Kaza, Aditya/0000-0003-3450-4496
CR Arabía FA, 2006, J HEART LUNG TRANSPL, V25, P16, DOI 10.1016/j.healun.2005.07.003
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Garatti A, 2007, J HEART LUNG TRANSPL, V26, P956, DOI 10.1016/j.healun.2007.06.007
   Holman WL, 2004, J HEART LUNG TRANSPL, V23, P1359, DOI 10.1016/j.healun.2003.09.025
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Stiller B, 2005, EUR J CARDIO-THORAC, V28, P234, DOI 10.1016/j.ejcts.2005.04.023
   Yuh DD, 2005, ANN THORAC SURG, V80, P1493, DOI 10.1016/j.athoracsur.2004.03.043
NR 8
TC 16
Z9 18
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-564X
EI 1525-1594
J9 ARTIF ORGANS
JI Artif. Organs
PD NOV
PY 2009
VL 33
IS 11
BP 922
EP 925
DI 10.1111/j.1525-1594.2009.00950.x
PG 4
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA 524EY
UT WOS:000272127800008
PM 19874282
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Ingemansson, R
   Martin, R
   Huddleston, E
AF Malmsjo, Malin
   Ingemansson, Richard
   Martin, Robin
   Huddleston, Elizabeth
TI Wound Edge Microvascular Blood Flow Effects of Negative Pressure
   Wound Therapy Using Gauze or Polyurethane Foam
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE blood flow; microvasculature; negative pressure wound therapy; wound
   filler
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL
AB The aim of this study was to examine the effects of negative pressure wound therapy (NPWT) on wound edge microvascular blood flow, comparing different wound fillers. Wounds were created on the backs of 7 pigs. NPWT was applied, using either foam or gauze, at -50,-75, -100, -125, -150, or -175 mm Hg. Microvascular blood flow was measured in muscle tissue, subcutaneous tissue, and in the wound bed, at 0.5, 1, and 2.5 cm from the wound edge, using laser Doppler velocimetry. Similar patterns of blood flow response were observed when using foam or gauze. At 2.5 cm from the wound edge there was an increase in microvascular blood flow, while blood flow was decreased closer (0.5 cm) to the wound edge. The blood flow effects were similar at the different levels of negative pressure in muscle tissue, subcutaneous tissue, and in the wound bed. Altered microvascular blood flow to the wound edge may be one of the mechanisms by which NPWT facilitates healing.
C1 [Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden.
   [Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Martin, Robin] Smith & Nephew Med Ltd, NPWT Strateg Business Unit, Kingston Upon Hull, N Humberside, England.
   [Huddleston, Elizabeth] Smith & Nephew Med Ltd, Emerging Business Grp, Kingston Upon Hull, N Humberside, England.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Smith & Nephew; Smith & Nephew
RP Malmsjö, M (通讯作者)，Vasc Res, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
OI Ingemansson, Richard/0000-0001-7623-8953; Martin,
   Robin/0000-0002-9314-0437; Maljö, Malin/0000-0001-9849-9599
FU Ake Wiberg Foundation; M. Bergvall Foundation; Anna-Lisa and Sven Erik
   Lundgrens Foundation; Smith & Nephew Medical Limited
FX Supported by the Ake Wiberg Foundation, the M. Bergvall Foundation, the
   Anna-Lisa and Sven Erik Lundgrens Foundation, and Smith & Nephew Medical
   Limited.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Banwell Paul, 2006, J Tissue Viability, V16, P16
   Campbell PE, 2006, J WOUND OSTOMY CONT, V33, P176, DOI 10.1097/00152192-200603000-00014
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   CHARIKER M E, 1989, Contemporary Surgery, V34, P59
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Greene AK, 2006, ANN PLAS SURG, V56, P418, DOI 10.1097/01.sap.0000202831.43294.02
   GRIMM A, 2008, STRAHLENTHER ONKOL, V3, P144
   Ichioka S, 2008, WOUND REPAIR REGEN, V16, P460, DOI 10.1111/j.1524-475X.2008.00390.x
   Jones SM, 2005, PLAST RECONSTR SURG, V116, P1023, DOI 10.1097/01.prs.0000178399.68254.13
   JONSSON K, 1991, ANN SURG, V214, P605, DOI 10.1097/00000658-199111000-00011
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   Miller MS, 2005, OSTOMY WOUND MANAG, V51, P44
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Petzina R, 2006, EUR J CARDIO-THORAC, V30, P85, DOI 10.1016/j.ejcts.2006.04.009
   Sjögren J, 2003, ANN THORAC SURG, V75, P1311, DOI 10.1016/S0003-4975(02)04570-8
   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
   ZOGRAFOS GC, 1992, ANN SURG, V215, P266, DOI 10.1097/00000658-199203000-00011
NR 23
TC 61
Z9 77
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2009
VL 63
IS 6
BP 676
EP 681
DI 10.1097/SAP.0b013e31819ae01b
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 526TG
UT WOS:000272316400022
PM 19887926
DA 2026-07-24
ER
PT J
AU Jacobs, S
   Simhaee, DA
   Marsano, A
   Fomovsky, GM
   Niedt, G
   Wu, JK
AF Jacobs, Sharone'
   Simhaee, David A.
   Marsano, Anna
   Fomovsky, Gregory M.
   Niedt, George
   Wu, June K.
TI Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in
   promoting wound healing: a rodent model
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article; Proceedings Paper
CT 20th Annual Symposium on Advanced Wound Care
CY APR 28-MAY 01, 2007
CL Tampa, FL
DE VAC device; Rat model; Wound healing; Angiogenesis
ID MICROVESSEL DENSITY; ANGIOGENESIS; PRESSURE; TUMORS
AB Background: The vacuum-assisted closure device (VAC) has revolutionised wound care, although molecular mechanisms are not well understood. We hypothesise that the VAC device induces production of pro-angiogenic factors and promotes formation of granulation tissue and healing.
   Methods: A novel rodent model of VAC wound healing was established. Excisional wounds were created on rat dorsa. Wounds were dressed with Tegaderm (control group), VAC Granulofoam (R) and Tegaderm(special control group), or VAC Granulofoam (R), T. R. A. C. PAD (R) with 125 mm Hg continuous negative pressure (VAC group). Wound closure rates were calculated as a percentage of initial wound sizes. Rats were sacrificed on postoperative days 3, 5 and 7; harvested tissues were processed for histology [haematoxylin & eosin (H&E), Masson's trichrome, picrosirius red] and Western blot analysis (CD31, vascular endothelial growth factor, basic fibroblast growth factor).
   Results: Statistically significant wound closure rates were achieved in the experimental group at all measured time points: day 3, 28.1% (VAC) vs 8.2% (control) and 8.8% (special control) (ANOVA, P < 0.0001); day 5, 45.3% ( VAC) vs 23.7% (control) and 22.5% ( special control) (ANOVA, P = 0.0003); day 7, 54.4% (VAC) vs 43.0% (control) and 31.5% (special control) (ANOVA; P < 0.0001). Morphological evaluation by Masson's trichrome stain showed increased collagen organisation and wound maturation in the VAC group. These wounds also showed increased expression of vascular endothelial growth factor and fibroblast growth factor-2 on day 5 by Western blot analysis.
   Conclusion: A small animal VAC wound model was established. Wounds treated with a VAC device showed accelerated wound closure rates, increased pro-angiogenic growth factor production and improved collagen deposition. Further application of this model may elucidate other mechanisms. (C) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Jacobs, Sharone'; Simhaee, David A.; Wu, June K.] Columbia Univ, Coll Phys & Surg, Div Plast & Reconstruct Surg, New York, NY USA.
   [Marsano, Anna; Fomovsky, Gregory M.] Columbia Univ, Coll Phys & Surg, Dept Biomed Engn, New York, NY USA.
   [Niedt, George] Columbia Univ, Coll Phys & Surg, Dept Dermatol, New York, NY USA.
C3 Columbia University; Columbia University; Columbia University
RP Wu, JK (通讯作者)，161 Ft Washington Ave,Suite 601, New York, NY 10032 USA.
EM jw92@columbia.edu
OI Marsano, Anna/0000-0002-3084-0823
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Fabian TS, 2000, AM SURGEON, V66, P1136
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   LABLER L, 2006, ZENTRALBL CHIR, V1, pS62
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   Saaristo A, 2006, AM J PATHOL, V169, P1080, DOI 10.2353/ajpath.2006.051251
   Samson D. J., 2004, AHRQ PUBLICATION
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NR 23
TC 88
Z9 106
U1 0
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD OCT
PY 2009
VL 62
IS 10
BP 1331
EP 1338
DI 10.1016/j.bjps.2008.03.024
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 529NJ
UT WOS:000272523800020
PM 18617451
DA 2026-07-24
ER
PT J
AU Durai, R
   Mownah, A
   Ng, PCH
AF Durai, R.
   Mownah, A.
   Ng, P. C. H.
TI Bridge vacuum-assisted closure: a novel technique of using a single
   vacuum machine for multiple adjacent wounds
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID THERAPY; INJURIES
AB Aims: To describe a simple method of applying the VAC dressing to multiple wounds. Methods: Applying a VAC dressing using a sponge bridge to allow the simultaneous treatment of multiple wounds. Results: Successful healing was achieved using this simple method. Conclusion: The use of a simple sponge bridge allowed the simultaneous treatment of two adjacent wounds.
C1 [Durai, R.; Mownah, A.; Ng, P. C. H.] Univ Hosp Lewisham, Dept Surg, London SE13 6LH, England.
C3 University of London; King's College London
RP Durai, R (通讯作者)，Lewisham Hosp NHS Trust, Lewisham High St, London SE13 6LH, England.
EM dr_durai@yahoo.com
CR Banwell PE, 2002, BRIT J PLAST SURG, V55, P264, DOI 10.1054/bjps.2001.3819
   Brown KM, 2001, ANN THORAC SURG, V72, P1409, DOI 10.1016/S0003-4975(01)02844-2
   Durai Rajaraman, 2008, J Perioper Pract, V18, P437
   Gregor S, 2008, ARCH SURG-CHICAGO, V143, P189, DOI 10.1001/archsurg.2007.54
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
NR 5
TC 4
Z9 4
U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1368-5031
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD JAN
PY 2010
VL 64
IS 1
BP 93
EP 94
DI 10.1111/j.1742-1241.2009.02007.x
PG 2
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 531HR
UT WOS:000272655800016
PM 20089017
DA 2026-07-24
ER
PT J
AU Gabriel, A
   Heinrich, C
   Shores, J
   Cho, D
   Baqai, W
   Moores, D
   Miles, D
   Gupta, S
AF Gabriel, Allen
   Heinrich, Cherrie
   Shores, Jaimie
   Cho, David
   Baqai, Waheed
   Moores, Donald
   Miles, Duncan
   Gupta, Subhas
TI Outcomes of vacuum-assisted closure for the treatment of wounds in a
   paediatric population: case series of 58 patients
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Wound care in paediatrics; VAC Therapy
   System; Vacuum-assisted closure
ID NEGATIVE-PRESSURE; MANAGEMENT; THERAPY
AB Objective: This retrospective case series describes our experiences and outcomes using the vacuum-assisted closure (VAC) Therapy System for the management of difficult acute and chronic wounds in paediatric patients.
   Summary background data: Difficult wounds that cannot be closed primarily can create major challenges in paediatric patient care. Decreasing the time to wound closure is especially critical when managing paediatric patients.
   Methods: A retrospective review of medical records for 58 consecutive paediatric patients treated with VAC therapy was performed. Demographics, diagnosis, length of therapy, time to closure, time to discharge, type of VAC dressing used, dressing change schedule, therapy settings, and complications were recorded for each patient.
   Results: The median age of all 58 patients was 10 years (range, 10 days to 16 years). Fifty-four of the 58 wounds reached full closure. Patients were divided into five different groups according to diagnosis. The median time to closure for each group follows: Group 1 (abdominal wounds) 10 days (range, 3-99 days); Group 2 (surgical soft tissue deficit) 12 days (range, 3-30 days); Group 3 (trauma wounds) 7 days (range, 3-10 days); Group 4 (stage III/IV pressure ulcers) 15 days (range, 14-15 days); Group 5 (fasciotomy wounds) 5 days (range, 5-10 days). No complications were recorded for any of the patients.
   Conclusions: The results demonstrate that VAC therapy may be a viable, safe and effective method of managing this difficult-to-treat population. (C) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Gabriel, Allen; Heinrich, Cherrie; Shores, Jaimie; Cho, David; Miles, Duncan; Gupta, Subhas] Loma Linda Univ, Dept Plast & Reconstruct Surg, Med Ctr, Loma Linda, CA 92354 USA.
   [Moores, Donald] Loma Linda Univ, Dept Paediat Surg, Med Ctr, Loma Linda, CA 92354 USA.
   [Baqai, Waheed] Loma Linda Univ, Hlth Res Consulting Grp, Loma Linda, CA 92354 USA.
C3 Loma Linda University; Loma Linda University; Loma Linda University
RP Gupta, S (通讯作者)，Loma Linda Univ, Dept Plast & Reconstruct Surg, Med Ctr, 11175 Campus Dr,Coleman Pavil 21126, Loma Linda, CA 92354 USA.
EM sgupta@ahs.llumc.edu
RI Gabriel, Allen/AFK-3548-2022; Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922; Shores, Jaimie/0000-0002-4272-1389
CR Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
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NR 35
TC 32
Z9 38
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD NOV
PY 2009
VL 62
IS 11
BP 1428
EP 1436
DI 10.1016/j.bjps.2008.06.033
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 536XW
UT WOS:000273078200013
PM 18835547
DA 2026-07-24
ER
PT J
AU Ennker, IC
   Pietrowski, D
   Vöhringer, L
   Kojcici, B
   Albert, A
   Vogt, PM
   Ennker, J
AF Ennker, I. C.
   Pietrowski, D.
   Voehringer, L.
   Kojcici, B.
   Albert, A.
   Vogt, P. M.
   Ennker, J.
TI Surgical debridement, vacuum therapy and pectoralis plasty in
   poststernotomy mediastinitis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Vacuum therapy; M. pectoralis muscle flaps; Mediastinitis; Sternotomy;
   Infection
ID STERNAL WOUND-INFECTION; ASSISTED CLOSURE; MEDIAN STERNOTOMY;
   RADIAL-ARTERY; LONG-TERM; DEEP; COMPLICATIONS
AB In cardiac surgery poststernotomy mediastinitis continues to be a serious cause of morbidity and mortality. We report our experience with vacuum-assisted closure (VAC) therapy followed by reconstruction with M. pectoralis muscle flaps as treatment for deep sternal wound infections. Our group performed a retrospective analysis of 3630 consecutive cardiac surgical patients using median sternotomy from 11/2004 to 11/2007. After removing sternal wires, necrotic debris and potentially infective material, restabilisation of the sternum was performed and VAC therapy was employed. Wound closure and subsequent reconstruction were performed using a bilateral pectoralis muscle plasty. Of the analysed patients 16 female and 29 male patients suffered from deep sternal wound infections and were treated with VAC. The most common risk factors were diabetes mellitus odds ratio (OR 3.5), chronic obstructive pulmonary disease (COPD) (OR 2.9), use of bilateral mammarian artery (OR 2.0) and obesity (1.8). The median age of patients with deep sternal infections was similar to control patients. Staphylococcus epidermis was the most common pathogen (37.8%) followed by Enterococcus faecilis (22.2%) and Staphylococcus aureus (17.8). In 22.2% no pathogen could be detected. The 30 day mortality was 0%, the in-hospital mortality was 15.6%. The results of our studies demonstrate that vacuum therapy in conjunction with early and aggressive debridement is an effective strategy for treating poststernotomy mediastinitis. We consider pectoralis major muscle flap reconstruction as a safe technique and regard it as the primary choice for wound closure in poststernotomy mediastinitis. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Ennker, I. C.; Vogt, P. M.] Hannover Med Sch, Klin Plast Hand & Wiederherstellungschirurg, D-30625 Hannover, Germany.
   [Ennker, I. C.; Pietrowski, D.; Voehringer, L.; Kojcici, B.; Albert, A.; Ennker, J.] Herzzentrum Lahr Baden, D-77933 Lahr, Germany.
C3 Hannover Medical School
RP Ennker, IC (通讯作者)，Hannover Med Sch, Klin Plast Hand & Wiederherstellungschirurg, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM ennker.ina@mh-hannover.de
RI ; Vogt, Peter/AAL-1332-2020
OI Vöhringer, Luise/0009-0001-4741-2980; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Borger MA, 1998, ANN THORAC SURG, V65, P1050, DOI 10.1016/S0003-4975(98)00063-0
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   De Feo M, 2001, ANN THORAC SURG, V71, P324, DOI 10.1016/S0003-4975(00)02137-8
   Desai ND, 2004, NEW ENGL J MED, V351, P2302, DOI 10.1056/NEJMoa040982
   Francel TJ, 2001, ANN THORAC SURG, V72, P1419, DOI 10.1016/S0003-4975(00)02009-9
   Gardner TJ, 2007, CIRCULATION, V115, P678, DOI 10.1161/CIRCULATIONAHA.106.675421
   Harlan JW, 2002, PLAST RECONSTR SURG, V109, P710, DOI 10.1097/00006534-200202000-00045
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Holle G, 2007, UNFALLCHIRURG, V110, P289, DOI 10.1007/s00113-007-1265-z
   Kurlansky PA, 2001, ANN THORAC SURG, V71, P1949, DOI 10.1016/S0003-4975(01)02592-9
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   Zacharias A, 1996, CHEST, V110, P1173, DOI 10.1378/chest.110.5.1173
NR 15
TC 35
Z9 39
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD NOV
PY 2009
VL 62
IS 11
BP 1479
EP 1483
DI 10.1016/j.bjps.2008.05.017
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 536XW
UT WOS:000273078200022
PM 18996074
DA 2026-07-24
ER
PT J
AU Acartürk, TO
AF Acarturk, Tahsin Oguz
TI Treatment of large ischial ulcers communicating with the hip joint with
   proximal femoral resection and reconstruction with a combined vastus
   lateralis, vastus intermedius and rectus femoris musculocutaneous flap
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Vastus lateralis; Vastus intermedius; Rectus femoris; Pressure sore;
   Flap; Vacuum-assisted closure; Lateral circumflex femoral artery;
   Girdlestone arthroplasty
ID PRESSURE SORES; MYOCUTANEOUS FLAP; THIGH FLAP; ARTHROPLASTY; MUSCLE;
   MANAGEMENT; INFECTION; CLOSURE
AB Pressure ulcers which communicate with the hip joint are very difficult to treat. Often, the hip joint is infected with osteomyelitis of the proximal femur resulting in bouts of sepsis and flap failure. These patients require proximal femoral resection and wide debridementin order to eradicate the infection, which in turn results in large and deep cavities. Reconstruction requires either a muscle flap or even a total thigh flap if the defect is very large and the pelvis is involved.
   In a series of six ischial or ischio-trochanteric pressure sores communicating with the hip joint, following multiple serial debridements, the vastus lateralis, vastus intermedius and rectus femoris muscles were raised as a single musculocutaneous flap ('three muscle flap'), based on the descending branch of the lateral femoral circumflex artery, and transposed into the defect. All patients were paraplegics and had signs of sepsis during admission. Two patients had prior failed reconstructions within 3 months of admission and the others had not been operated on before. The external skin defect of the ulcers ranged from 7 x 5 cm to 30 x 12 cm. After 12 months follow up there was no recurrence of pressure sores or sepsis.
   The 'three muscle flap' offers the advantage of providing large bulk to fill deep cavities, while preserving the rest of the thigh. The flap elevation is fast and safe and the vascular pedicle is reliable. This technique is not for simple pressure sores, but should be reserved for large pressure sores complicated with large cavities created after resection of the proximal femur. (C) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 Cukurova Univ, Sch Med, Dept Plast Reconstruct & Aesthet Surg, TR-01330 Adana, Turkey.
C3 Cukurova University
RP Acartürk, TO (通讯作者)，Cukurova Univ, Sch Med, Dept Plast Reconstruct & Aesthet Surg, TR-01330 Adana, Turkey.
EM toacarturk@yahoo.com
RI Acarturk, Tahsin/MIT-6667-2025
CR BERGER SR, 1994, ANN PLAS SURG, V33, P548, DOI 10.1097/00000637-199411000-00014
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NR 16
TC 24
Z9 26
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD NOV
PY 2009
VL 62
IS 11
BP 1497
EP 1502
DI 10.1016/j.bjps.2008.04.063
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 536XW
UT WOS:000273078200025
PM 18718837
DA 2026-07-24
ER
PT J
AU Kairinos, N
   Solomons, M
   Hudson, DA
AF Kairinos, Nicolas
   Solomons, Michael
   Hudson, Donald A.
TI The paradox of negative pressure wound therapy - in vitro studies
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article; Proceedings Paper
CT 37th Annual Congress of the
   South-African-Society-for-Surgery-to-the-Hand
CY SEP 04-05, 2006
CL Durban, SOUTH AFRICA
SP S African Soc Surg Hand
DE Negative-pressure wound therapy; Topical negative pressure; Vacuum
   dressings; Suction dressings; VAC; Tissue pressure
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; BLOOD-FLOW
AB Negative-pressure wound therapy (NPWT) has revolutionised wound care. Yet, it is still not understood how hypobaric tissue pressure accelerates wound healing. There is very little reported on the relevant physics of any substance subjected to suction in this manner. The common assumption is that applying suction to a substance is likely to result in a reduction of pressure in that substance. Although more than 250 research articles have been published on NPWT, there are little data verifying whether suction increases or decreases the pressure of the substance it is applied to. Clarifying this basic question of physics is the first step in understanding the mechanism of action of these dressings.
   In this study, pressure changes were recorded in soft plasticene and processed meat, using an intracranial tissue pressure microsensor. Circumferential, non-circumferential and cavity NPWT dressings were applied, and pressure changes within the underlying substance were recorded at different suction pressures. Pressures were also measured at 1 cm, 2 cm and 3 cm from the NPWT placed in a cavity.
   In all three types of NPWT dressings, the underlying substance pressure was increased (hyperbaric) as suction pressure increased. Although there was a substantial pressure increase at 1 cm, the rise in pressure at the 2-cm and 3-cm intervals was minimal.
   Substance pressure beneath all types of NPWT dressing is hyperbaric in inanimate substances. Higher suction pressures generate greater substance pressures; however, the increased pressure rapidly dissipates as the distance from the dressing is increased. The findings of this study on inanimate objects suggest that we may need to review our current perception of the physics underlying NPWT dressings. Further research of this type on living tissues is warranted. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 Groote Schuur Hosp, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
   Univ Cape Town, ZA-7700 Rondebosch, South Africa.
C3 University of Cape Town; University of Cape Town
RP Kairinos, N (通讯作者)，Groote Schuur Hosp, Dept Plast Surg, H53 Old Main Bldg,Main Rd, ZA-7925 Cape Town, South Africa.
EM nickykairinos@gmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Kamolz LP, 2004, BURNS, V30, P253, DOI 10.1016/j.burns.2003.12.003
   Mendonca Derick A, 2006, Int Wound J, V3, P261, DOI 10.1111/j.1742-481X.2006.00266.x
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Petzina R, 2006, EUR J CARDIO-THORAC, V30, P85, DOI 10.1016/j.ejcts.2006.04.009
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Stone PA, 2004, J TRAUMA, V57, P1082, DOI 10.1097/01.TA.0000149248.02598.9E
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
   Willy C, 2006, ZBL CHIR, V131, pS50, DOI 10.1055/s-2006-921421
NR 12
TC 74
Z9 85
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JAN
PY 2010
VL 63
IS 1
BP 174
EP 179
DI 10.1016/j.bjps.2008.08.037
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 536YA
UT WOS:000273078600028
PM 19036656
DA 2026-07-24
ER
PT J
AU Gdalevitch, P
   Afilalo, J
   Lee, C
AF Gdalevitch, Perry
   Afilalo, Jonathan
   Lee, Chen
TI Predictors of vacuum-assisted closure failure of sternotomy wounds
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Sternal wound; Sternotomy wound infection; Sternal wound complications;
   Sternal wound reconstruction; Vacuum-assisted closure (VAC);
   Mediastinitis
ID CARDIAC-SURGERY; MEDIASTINITIS; BRIDGE
AB Purpose: Vacuum-assisted closure (VAC) is a minimally invasive alternative to a muscle flap for closure of sternotomy wounds. The purpose of this study is to evaluate clinical predictors of VAC therapy failure in order to predict which patients would benefit from this approach.
   Methods: A retrospective cohort study of all patients with VAC management of sternotomy wounds between January 1997 and July 2003 was conducted. In this study, 37 patients had VAC management of their wounds post-cardiac surgery. Prior to data collection, 12 risk factors for impaired wound healing were identified. Information was obtained from patient charts and laboratory values.
   Results: Eight of the 36 patients failed the VAC therapy. Of the 12 variables studied, three were found to be predictive of VAC outcome. Bacteraemic patients had a higher failure rate as compared to patients with negative blood cultures (p <= 0.01). Patients with wound depth >= 4 cm also had a greater occurrence of VAC failure (p <= 0.01). Finally, VAC failure was significantly higher in patients who had a high degree of bony exposure and sternal instability (BESI, p <= 0.03). Patient characteristics and co-morbidities traditionally associated with impaired wound healing did not appear to worsen outcome with VAC.
   Conclusion: Patients who have positive blood cultures, wound depth >= 4 cm or a high degree of BESI tend to have worse outcomes with VAC and may be better managed by a surgical approach. Otherwise, VAC may be a reasonable option even in patients with high risks of impaired wound healing. Prospective randomised studies are needed to validate these hypotheses. Crown Copyright (C) 2008 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons. All rights reserved.
C1 [Gdalevitch, Perry; Lee, Chen] Univ Montreal, Dept Plast & Reconstruct Surg, Montreal, PQ, Canada.
   [Afilalo, Jonathan] McGill Univ, Dept Plast & Reconstruct Surg, Montreal, PQ, Canada.
C3 Universite de Montreal; McGill University
RP Gdalevitch, P (通讯作者)，12 Armstrong, Montreal, PQ H9G 2J7, Canada.
EM perritwin@hotmail.com
RI Afilalo, Jonathan/AEP-0841-2022
CR Anthony S., 1997, HARRISONS PRINCIPLES
   Atiyeh Bishara S., 2002, Current Pharmaceutical Biotechnology, V3, P179, DOI 10.2174/1389201023378283
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Francel TJ, 2001, ANN THORAC SURG, V72, P1411, DOI 10.1016/S0003-4975(00)02008-7
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Luckraz H, 2003, J THORAC CARDIOV SUR, V125, P301, DOI 10.1067/mtc.2003.74
   MADER J, 1995, PRINCIPLES PRACTICE
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 12
TC 20
Z9 22
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JAN
PY 2010
VL 63
IS 1
BP 180
EP 183
DI 10.1016/j.bjps.2008.08.020
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 536YA
UT WOS:000273078600029
PM 19028156
DA 2026-07-24
ER
PT J
AU Leffler, M
   Horch, RE
   Dragu, A
   Bach, AD
AF Leffler, M.
   Horch, R. E.
   Dragu, A.
   Bach, A. D.
TI The use of the artificial dermis (Integra®) in combination with vacuum
   assisted closure for reconstruction of an extensive burn scar - A case
   report
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article; Proceedings Paper
CT Congress of the
   German-and-Austrian-Society-of-Plastic-Reconstructive-and-Aesthetic-Surg
   eons
CY OCT 02-04, 2008
CL Stuttgart, GERMANY
SP DGPRAC, VDAPC, OGPARC
DE Burn; Skin gafting; Artifical dermis; Topical negative pressure
ID NEGATIVE-PRESSURE
AB The artificial dermis Integra (R) (Ethicon (R), Johnson & Johnson Medical, Norderstedt, Germany) is widely used in the treatment of excessive burn injuries. It is also used in reconstructive surgery when large soft-tissue defects could not be covered with local or free flaps. In this article a 25-year old patient who presented with an early childhood burn of the trunk and lower extremity was treated with Integra (R) in combination with the vacuum assisted closure (V.A.C.(R), KCI, Texas, U.S.A.) and split thickness skin grafting. The combination of the artifical dermal substitute with negative pressure therapy has lead to a complete healing of Integra (R) and the skin graft. During the whole treatment sterile wound conditions were present and time-consuming dressing changes could be prevented. Hospital stay was shortened because the patient could be treated as an outpatient with an ambulant vacuum assisted closure device. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Leffler, M.; Horch, R. E.; Dragu, A.; Bach, A. D.] Univ Hosp Erlangen, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Leffler, M (通讯作者)，Univ Hosp Erlangen, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM Mareike.Leffler@uk-erlangen.de
RI Horch, Raymund E/H-8128-2019; Dragu, Adrian/AAH-3506-2019
OI Horch, Raymund E/0000-0002-6561-2353; Dragu, Adrian/0000-0003-4633-2695
CR BURKE JF, 1981, ANN SURG, V194, P413, DOI 10.1097/00000658-198110000-00005
   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   Molnar JA, 2004, PLAST RECONSTR SURG, V113, P1339, DOI 10.1097/01.PRS.0000112746.67050.68
   Pollard RLE, 2008, J PLAST RECONSTR AES, V61, P319, DOI 10.1016/j.bjps.2007.10.029
   Unglaub F, 2005, ZBL CHIR, V130, P157, DOI 10.1055/s-2005-836367
NR 5
TC 32
Z9 35
U1 0
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JAN
PY 2010
VL 63
IS 1
BP E32
EP E35
DI 10.1016/j.bjps.2009.05.022
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 536YA
UT WOS:000273078600041
PM 19523890
DA 2026-07-24
ER
PT J
AU Sinna, R
   Qassemyar, Q
   Boloorchi, A
   Benhaim, T
   Carton, S
   Perignon, D
   Robbe, M
AF Sinna, R.
   Qassemyar, Q.
   Boloorchi, A.
   Benhaim, T.
   Carton, S.
   Perignon, D.
   Robbe, M.
TI Role of the association artificial dermis and negative pressure therapy:
   About two cases
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Artificial dermis; Negative pressure therapy; Medicoeconomic benefits
ID SKIN SUBSTITUTES; MANAGEMENT; TEMPLATE; INTEGRA; TISSUE; BURNS
AB In our modern health system, the improvement of the medical care cannot come along with an increase of expenses. In this purpose, we tried to bring to light the medical and economic, direct and indirect, benefits which exist with the association of an artificial dermis, Integra(R), and negative pressure therapy as the vacuum assisted closure (VAC(R)) for wound which would have been treated by Integra(R) alone. While preserving the aesthetic and functional qualities obtained by the artificial dermis alone followed by a skin graft after 21 days of treatment, the association of the negative pressure allows to perform the skin graft after only 10 days of treatment. This gain of time is a financial economy for the medical centers which have to shorten the durations of stay to be profitable. The patient benefits of a shorter hospitalization and will manage to return to work earlier. The quality of the treatment is not only improved by the absentia of immobilization of the patient but also by the decrease of the complications and the infectious risks due to the use of artificial dermis. The results so obtained highlight that in spite of the initial expense caused by this association the advantages are such that the use of the artificial dermis alone will not have interest any more. (C) 2009 Elsevier Masson SAS. All rights reserved.
C1 [Sinna, R.; Qassemyar, Q.; Boloorchi, A.; Benhaim, T.; Carton, S.; Perignon, D.; Robbe, M.] CHU Nord Amiens, Hop Nord, Serv Chirurg Plast Reconstructrice & Esthet, F-80054 Amiens 1, France.
C3 Universite de Picardie Jules Verne (UPJV); CHU Amiens
RP Sinna, R (通讯作者)，CHU Nord Amiens, Hop Nord, Serv Chirurg Plast Reconstructrice & Esthet, Pl Victor Pauchet, F-80054 Amiens 1, France.
EM raphaelsinna@gmail.com
RI Qassemyar, Quentin/AAF-5105-2019
CR [Anonymous], ANN PLAST SURG
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Dantzer E, 2001, Ann Chir Plast Esthet, V46, P173, DOI 10.1016/S0294-1260(01)00019-X
   Dantzer E, 2003, BRIT J PLAST SURG, V56, P764, DOI 10.1016/S0007-1226(03)00366-7
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NR 15
TC 10
Z9 10
U1 0
U2 4
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD DEC
PY 2009
VL 54
IS 6
BP 582
EP 587
DI 10.1016/j.anplas.2009.02.003
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 538CE
UT WOS:000273160900011
PM 19345466
DA 2026-07-24
ER
PT J
AU Kirkby, KA
   Wheeler, JL
   Farese, JP
   Ellison, GW
   Bacon, NJ
   Sereda, CW
   Lewis, DD
AF Kirkby, Kristin A.
   Wheeler, Jason L.
   Farese, James P.
   Ellison, Gary W.
   Bacon, Nicholas J.
   Sereda, Colin W.
   Lewis, Daniel D.
TI Vacuum-Assisted Wound Closure: Application and Mechanism of Action
SO COMPENDIUM-CONTINUING EDUCATION FOR VETERINARIANS
LA English
DT Article
AB Vacuum-assisted closure (VAC) is a wound management therapy that creates local negative pressure over a wound bed to promote healing. Benefits of VAC therapy include removal of fluid from the extravascular space, improved circulation, enhanced granulation tissue formation, increased bacterial clearance, and hastening of wound closure. This article describes the mechanism of action of VAC therapy, reviews application techniques, and lists potential complications and contraindications.
C1 [Kirkby, Kristin A.; Wheeler, Jason L.; Farese, James P.; Ellison, Gary W.; Bacon, Nicholas J.; Sereda, Colin W.; Lewis, Daniel D.] Univ Florida, Gainesville, FL 32611 USA.
C3 State University System of Florida; University of Florida
RP Kirkby, KA (通讯作者)，Univ Florida, Gainesville, FL 32611 USA.
OI Bacon, Nicholas/0000-0001-5190-5342
NR 0
TC 5
Z9 5
U1 0
U2 1
PU VETERINARY LEARNING SYSTEMS
PI YARDLEY
PA 780 TOWNSHIP LINE RD, YARDLEY, PA 19067-4200 USA
SN 1940-8307
J9 COMPENDIUM
JI Compendium
PD DEC
PY 2009
VL 31
IS 12
BP 568
EP +
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 539VQ
UT WOS:000273287200004
DA 2026-07-24
ER
PT J
AU Kelm, J
   Schmitt, E
   Anagnostakos, K
AF Kelm, Jens
   Schmitt, Eduard
   Anagnostakos, Konstantinos
TI Vacuum-assisted closure in the treatment of early hip joint infections
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE vacuum-assisted closure; VAC-therapy; early infection; hip joint
ID THERAPY
AB The aim of the present study was to evaluate the efficacy of the vacuum-assisted closure (V.A.C.) system in the treatment of early hip joint infections. 28 patients (11 m/17 f; mean age 71 y. [43-84]) with early hip joint infections have been treated by means of the V.A.C.-therapy. At least one surgical revision [1-7] has been unsuccessfully performed for infection treatment prior to V.A.C.-application. Pathogen organisms could have been isolated in 22/28 wounds. During revision, cup inlay and prosthesis head have been exchanged and 1-3 polyvinylalcohol sponges inserted into the wound cavity/periprosthetically at an initial continuous pressure of 200 mm Hg. Postoperatively, a systemic antibiosis was given according to antibiogram. 48-72 h after surgery an alteration from haemorrhagic to serous fluid was observed in the V.A.C.-canister. Afterwards, the pressure was decreased to 150 mm Hg and remained at this level till sponge removal. After a mean period of 9 [3-16] days the inflammation parameters have been retrogressive and the sponges were removed. An infection eradication could be achieved in 26/28 cases. In the two remaining cases the infected prosthesis had to be explanted and a gentamicin-vancomycin-loaded spacer has been implanted, respectively. At a total mean follow-up of 36 [12-87] months no reinfection or infection persistence was observed. The V.A.C.-system can be a valuable contribution in the treatment of early joint infections when properly used. Indications should be early infections with well-maintained soft-tissues for retention of the negative atmospheric pressure.
C1 [Kelm, Jens; Schmitt, Eduard; Anagnostakos, Konstantinos] Univ Saarland, Dept Orthopaed Surg, Univ Hosp, D-6650 Homburg, Germany.
   [Kelm, Jens] Chirurg Orthopad Zentrum Illingen Saar, Saar, Germany.
C3 Universitatsklinikum des Saarlandes; Saarland University
RP Anagnostakos, K (通讯作者)，Univ Saarlandes Kliniken, Klin Orthopadie & Orthopad Chirurg, Kirrbergerstr 1, D-66421 Homburg, Germany.
EM k.anagnostakos@web.de
RI Anagnostakos, Konstantinos/MGC-8753-2025
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NR 17
TC 39
Z9 47
U1 0
U2 7
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2009
VL 6
IS 5
BP 241
EP 246
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 541HE
UT WOS:000273405100003
PM 19834589
DA 2026-07-24
ER
PT J
AU Melvin, JS
   Dombroski, DG
   Torbert, JT
   Kovach, SJ
   Esterhai, JL
   Mehta, S
AF Melvin, J. Stuart
   Dombroski, Derek G.
   Torbert, Jesse T.
   Kovach, Stephen J.
   Esterhai, John L.
   Mehta, Samir
TI Open Tibial Shaft Fractures: I. Evaluation and Initial Wound Management
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID OPEN EXTREMITY FRACTURES; VACUUM-ASSISTED CLOSURE; SOFT-TISSUE;
   ANTIBIOTIC-THERAPY; INFECTION-RATE; BONE; PRESSURE; LAVAGE; IRRIGATION;
   BACTERIA
AB Open fractures of the tibial diaphysis are often associated with severe bone and soft-tissue injury. Contamination of the fracture site and devitalization of the soft-tissue envelope greatly increase the risk of infection, nonunion, and wound complications. Management of open tibial shaft fractures begins with a thorough patient evaluation, including assessment of the bone and soft tissue surrounding the tibial injury. Classification of these injuries according to the system of Gustilo and Anderson at the time of surgical debridement is useful in guiding treatment and predicting outcomes. Administration of antibiotic prophylaxis as soon as possible after injury as well as urgent and thorough debridement, irrigation, and bony stabilization are done to minimize the risk of infection and improve outcomes. The use of antibiotic bead pouches and negative-pressure wound therapy has proved to be efficacious for the acute, temporary management of severe bone and soft-tissue defects.
C1 [Melvin, J. Stuart; Dombroski, Derek G.; Torbert, Jesse T.; Esterhai, John L.] Univ Penn, Dept Orthopaed Surg, Philadelphia, PA 19104 USA.
   [Kovach, Stephen J.] Univ Penn, Div Plast Surg, Philadelphia, PA 19104 USA.
   [Mehta, Samir] Univ Penn, Orthopaed Trauma & Fracture Serv, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania
RP Melvin, JS (通讯作者)，Univ Penn, Dept Orthopaed Surg, Philadelphia, PA 19104 USA.
CR Aderinto J, 2008, J BONE JOINT SURG BR, V90B, P638, DOI 10.1302/0301-620X.90B5.19854
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NR 48
TC 88
Z9 114
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD JAN
PY 2010
VL 18
IS 1
BP 10
EP 19
PG 10
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 543LD
UT WOS:000273578100002
PM 20044487
DA 2026-07-24
ER
PT J
AU Renner, C
   Reschke, S
   Richter, W
AF Renner, Christian
   Reschke, Susanne
   Richter, Wolfgang
TI Thoracic Empyema After Pneumonectomy: Intrathoracic Application of
   Vacuum-Assisted Closure Therapy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
AB We report the use of vacuum-assisted closure (V.A.C. Therapy, KCI Medical, Wiesbaden, Germany) to treat an intrathoracic empyema that occurred after resection of the right lung. Successful closure of the thoracic cavity was achieved with an omental plombage. (Ann Thorac Surg 2010;89:603-4) (C) 2010 by The Society of Thoracic Surgeons
C1 [Renner, Christian; Reschke, Susanne; Richter, Wolfgang] Kliniken Kreis Muehldorf Inn, Dept Surg, D-84453 Muehldorf, Germany.
RP Renner, C (通讯作者)，Kliniken Kreis Muehldorf Inn, Dept Surg, Krankenhausstr 1, D-84453 Muehldorf, Germany.
EM mail@drchristianrenner.de
CR Ditterich D, 2006, ZBL CHIR, V131, pS133, DOI 10.1055/s-2006-921499
   Ditterich D, 2004, ZBL CHIR, V129, pS137
   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
NR 3
TC 10
Z9 10
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD FEB
PY 2010
VL 89
IS 2
BP 603
EP 604
DI 10.1016/j.athoracsur.2009.06.037
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 547BV
UT WOS:000273861100050
PM 20103353
DA 2026-07-24
ER
PT J
AU Aydin, U
   Ozgenel, Y
   Kanturk, R
AF Aydin, Ufuk
   Ozgenel, Yesim
   Kanturk, Riza
TI Vacuum-assisted closure therapy in newborn gangrene
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Newborn; Gangrene; Vacuum-Assisted Closure Therapy
AB Gangrene of the newborn or neonatal gangrene is very uncommon, and it usually involves the extremities. Neonatal gangrene seems to be more frequent in pregnancies re-leated with spontaneus rupture of the amniotic sac leading to delayed delivery or dry labour. However, in most of the cases, no aetiological factor can be found. Foetal pressure necrosis and amniotic band sequence are two of the most common causes of this condition. Thrombosis, emboli, congenital heart disease, coagulopathy, sepsis and polycythaemia are some of the other aetiologic factors. Treatment of this condition is usually conservative and supportive. Conservative treatment includes adequate hydration, prevention from infections and allowing the involved area to demarcate in an aseptic environment. In some cases, surgical debridement and further reconstruction can be necessary. In order to prepare the wound bed for surgical closure after surgical debridement, vacuum-assisted closure (VAC) therapy can be a new, highly effective method in the treatment of newborn gangrene. In this article, a case of a neonatal gangrene treated with the application of VAC therapy is presented. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Aydin, Ufuk; Ozgenel, Yesim; Kanturk, Riza] Uludag Univ, Dept Plast & Reconstruct & Aesthet Surg, TR-16059 Bursa, Turkey.
C3 Uludag University
RP Aydin, U (通讯作者)，Uludag Univ, Dept Plast & Reconstruct & Aesthet Surg, Gorukle Campus, TR-16059 Bursa, Turkey.
EM drufukaydin@gmail.com
CR Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
   HENSINGER RN, 1975, J BONE JOINT SURG AM, VA 57, P121, DOI 10.2106/00004623-197557010-00025
   MARJORIEARCA J, 2005, PEDIAT SURG INT, V21, P532
   Özgenel GY, 2000, EUR J PLAST SURG, V23, P429, DOI 10.1007/s002380000194
   Ramnarine IR, 2002, EUR J CARDIO-THORAC, V22, P1029, DOI 10.1016/S1010-7940(02)00562-6
NR 5
TC 6
Z9 7
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAR
PY 2010
VL 63
IS 3
BP E277
EP E279
DI 10.1016/j.bjps.2009.05.049
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 551JA
UT WOS:000274202700046
PM 19581134
DA 2026-07-24
ER
PT J
AU Psoinos, CM
   Ignotz, RA
   Lalikos, JF
   Fudem, G
   Savoie, P
   Dunn, RM
AF Psoinos, Charles M.
   Ignotz, Ronald A.
   Lalikos, Janice F.
   Fudem, Gary
   Savoie, Paul
   Dunn, Raymond M.
TI Use of gauze-based negative pressure wound therapy in a pediatric burn
   patient
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Negative pressure; Pediatric; Burn; Skin graft
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; BOLSTER
AB Negative pressure wound therapy (NPWT) is described as it is used in the treatment of an infant burn victim. This case highlights the ability and techniques used to maintain an airtight dressing seal in the perirectal region. Use of this dressing type post-skin grafting allowed for 100% graft adhesion and no bacterial contamination despite close proximity to the rectum. Favorable experience and outcome with this patient are strong indicators that NPWT should be considered as a viable treatment in pediatric populations and that situations where body contour or fluids may make NPWT difficult to administer should not be a deterrent to therapy. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Psoinos, Charles M.; Ignotz, Ronald A.; Lalikos, Janice F.; Fudem, Gary; Savoie, Paul; Dunn, Raymond M.] Univ Massachusetts Mem, Div Plast Surg, Med Ctr, Worcester, MA 01655 USA.
C3 University of Massachusetts System; University of Massachusetts
   Worcester
RP Ignotz, RA (通讯作者)，Univ Massachusetts Mem, Div Plast Surg, Med Ctr, Worcester, MA 01655 USA.
EM ronald.ignotz@umassmed.edu
RI Dunn, Riley/GWC-9868-2022
CR Abai B, 2007, J VASC SURG, V45, P610, DOI 10.1016/j.jvs.2006.10.043
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bookout Kimberly, 2004, J Wound Ostomy Continence Nurs, V31, P184
   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   CHARIKER M E, 1989, Contemporary Surgery, V34, P59
   Chariker ME, 2009, PLAST RECONSTR SURG, V123, P1510, DOI 10.1097/PRS.0b013e3181a20563
   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
   GWOSDOW AR, 1993, J BURN CARE REHABIL, P450
   McCord SS, 2007, WOUND REPAIR REGEN, V15, P296, DOI 10.1111/j.1524-475X.2007.00229.x
   Mouës CM, 2008, WOUND REPAIR REGEN, V16, P488, DOI 10.1111/j.1524-475X.2008.00395.x
   Schintler M, 2005, BURNS, V31, P1050, DOI 10.1016/j.burns.2005.03.003
   Simman R, 2004, WOUNDS, V16, P76
   SUSSMAN C, 2006, WOUND CARE COLLABORA, P298
   Thompson G, 2008, BR J COMMUNITY NURS, V13, pS26
   Thompson G., 2008, BR J COMMUNITY NURS, V13, pS28
   Thompson Geoff, 2008, Br J Community Nurs, V13, pS23
   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
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   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
NR 21
TC 12
Z9 15
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD DEC
PY 2009
VL 44
IS 12
BP E23
EP E26
DI 10.1016/j.jpedsurg.2009.09.022
PG 4
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 553VA
UT WOS:000274393700055
PM 20006000
DA 2026-07-24
ER
PT J
AU Batacchi, S
   Matano, S
   Nella, A
   Zagli, G
   Bonizzoli, M
   Pasquini, A
   Anichini, V
   Tucci, V
   Manca, G
   Ban, K
   Valeri, A
   Peris, A
AF Batacchi, Stefano
   Matano, Stefania
   Nella, Alessandra
   Zagli, Giovanni
   Bonizzoli, Manuela
   Pasquini, Andrea
   Anichini, Valentina
   Tucci, Valentina
   Manca, Giuseppe
   Ban, Kevin
   Valeri, Andrea
   Peris, Adriano
TI Vacuum-assisted closure device enhances recovery of critically ill
   patients following emergency surgical procedures
SO CRITICAL CARE
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION;
   INTERNATIONAL-CONFERENCE; FASCIAL CLOSURE; OPEN ABDOMEN; PRESSURE;
   MANAGEMENT; HEMORRHAGE; EXPERTS
AB Introduction Critically ill surgical patients frequently develop intra-abdominal hypertension (IAH) leading to abdominal compartment syndrome (ACS) with subsequent high mortality. We compared two temporary abdominal closure systems (Bogota bag and vacuum-assisted closure (VAC) device) in intra-abdominal pressure (IAP) control.
   Methods This prospective study with a historical control included 66 patients admitted to a medical and surgical intensive care unit (ICU) of a tertiary care referral center (Careggi Hospital, Florence, Italy) from January 2006 to April 2009. The control group included patients consecutively treated with the Bogota bag (Jan 2006-Oct 2007), whereas the prospective group was comprised of patients treated with a VAC. All patients underwent abdominal decompressive surgery. Groups were compared based upon their IAP, SOFA score, serial arterial lactates, the duration of having their abdomen open, the need for mechanical ventilation (MV) along with length of ICU and hospital stay and mortality. Data were collected from the time of abdominal decompression until the end of pressure monitoring.
   Results The Bogota and VAC groups were similar with regards to demography, admission diagnosis, severity of illness, and IAH grading. The VAC system was more effective in controlling IAP (P < 0.01) and normalizing serum lactates (P < 0.001) as compared to the Bogota bag during the first 24 hours after surgical decompression. There was no significant difference between the SOFA scores. When compared to the Bogota, the VAC group had a faster abdominal closure time (4.4 vs 6.6 days, P = 0.025), shorter duration of MV (7.1 vs 9.9 days, P = 0.039), decreased ICU length of stay (LOS) (13.3 vs 19.2 days, P = 0.024) and hospital LOS (28.5 vs 34.9 days; P = 0.019). Mortality rate did not differ significantly between the two groups.
   Conclusions Patients with abdominal compartment syndrome who were treated with VAC decompression had a faster abdominal closure rate and earlier discharge from the ICU as compared to similar patients treated with the Bogota bag.
C1 [Batacchi, Stefano; Matano, Stefania; Nella, Alessandra; Zagli, Giovanni; Bonizzoli, Manuela; Pasquini, Andrea; Anichini, Valentina; Tucci, Valentina; Peris, Adriano] Careggi Teaching Hosp, Emergency Dept, Anaesthesia & Intens Care Unit, I-50139 Florence, Italy.
   [Manca, Giuseppe; Valeri, Andrea] Careggi Teaching Hosp, Dept Gen Surg, I-50139 Florence, Italy.
   [Ban, Kevin] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Emergency Med, Boston, MA 02215 USA.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi;
   University of Florence; Azienda Ospedaliero Universitaria Careggi;
   Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center
RP Zagli, G (通讯作者)，Careggi Teaching Hosp, Emergency Dept, Anaesthesia & Intens Care Unit, Viale Morgagni 85, I-50139 Florence, Italy.
EM giovanni.zagli@unifi.it
FU institutional funds
FX The study was supported by institutional funds only.
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NR 28
TC 73
Z9 83
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1466-609X
EI 1364-8535
J9 CRIT CARE
JI Crit. Care
PY 2009
VL 13
IS 6
AR R194
DI 10.1186/cc8193
PG 8
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 556DF
UT WOS:000274567900023
PM 19961614
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Borgquist, O
   Ingemansson, R
   Malmsjö, M
AF Borgquist, Ola
   Ingemansson, Richard
   Malmsjo, Malin
TI Wound Edge Microvascular Blood Flow during Negative-Pressure Wound
   Therapy: Examining the Effects of Pressures from-10 to-175 mmHg
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; STATE
AB Background: Negative-pressure wound therapy is believed to accelerate wound healing by altered wound edge microvascular blood flow. The current standard negative pressure is -125 mmHg. However, this pressure may cause pain and ischemia and often has to be reduced. The aim of the present study was to examine the blood flow effects of different levels of negative pressures (-10 to -175 mmHg).
   Methods: Wound edge microvascular blood flow was studied in a peripheral wound model in eight 70-kg pigs on application of negative-pressure wound therapy. Blood flow was examined, using laser Doppler velocimetry, in subcutaneous and muscle tissue at 0.5, 2.5, and 5 cm from the wound edge.
   Results: Blood flow changed gradually with increasing negative pressure until reaching a steady state. Blood flow decreased close to the wound edge (0.5 cm) and increased farther from the wound edge (2.5 cm). At 0.5 cm, blood flow decreased 15 percent at -10 mmHg, 64 percent at -45 mmHg, and 97 percent at -80 mmHg. At 2.5 cm, blood flow increased 6 percent at -10 mmHg, 32 percent at -45 mmHg, and 90 percent at -80 mmHg. Higher levels of negative pressure did not have additional blood flow effects (p > 0.30). No blood flow effects were seen 5 cm from the wound edge.
   Conclusions: Blood flow changes gradually when the negative pressure is increased. The levels of pressure for negative-pressure wound therapy may be tailored depending on the wound type and tissue composition, and this study implies that -80 mmHg has similar blood flow effects as the clinical standard, -125 mmHg. (Plast. Reconstr. Surg. 125: 502, 2010.)
C1 Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，Vasc Res, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Borgquist, Ola/AAO-6451-2020
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599
FU Ake-Wieberg Foundation; Magn. Bergvall Foundation; Swedish Medical
   Association; Royal Physiographic Society in Lund; Swedish Medical
   Research Council; Crafoord Foundation; Swedish Heart-Lung Foundation;
   Swedish Government; Swedish Hypertension Society
FX The study was supported by the Ake-Wieberg Foundation, the Magn.
   Bergvall Foundation, the Swedish Medical Association, the Royal
   Physiographic Society in Lund, the Swedish Medical Research Council, the
   Crafoord Foundation, the Swedish Heart-Lung Foundation, the Swedish
   Government Grant for Clinical Research, and the Swedish Hypertension
   Society. The authors thank Rola Ba-Abbad, Bodil Gesslein, and Gisela
   Hakansson, for contributing to the experimental work, and Prospera, for
   valuable support.
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NR 32
TC 132
Z9 172
U1 0
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD FEB
PY 2010
VL 125
IS 2
BP 502
EP 509
DI 10.1097/PRS.0b013e3181c82e1f
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 558KS
UT WOS:000274741700010
PM 20124835
DA 2026-07-24
ER
PT J
AU Wedemeyer, J
   Brangewitz, M
   Kubicka, S
   Jackobs, S
   Winkler, M
   Neipp, M
   Klempnauer, J
   Manns, MP
   Schneider, AS
AF Wedemeyer, Jochen
   Brangewitz, Mira
   Kubicka, Stefan
   Jackobs, Steffan
   Winkler, Michael
   Neipp, Michael
   Klempnauer, Juergen
   Manns, Michael P.
   Schneider, Andrea S.
TI Management of major postsurgical gastroesophageal intrathoracic leaks
   with an endoscopic vacuum-assisted closure system
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Article
ID ESOPHAGEAL ANASTOMOTIC LEAKS; PRESSURE WOUND THERAPY; GASTRIC-CARCINOMA;
   PLASTIC STENTS; FIBRIN GLUE; SURGERY; PERFORATIONS; EXPERIENCE; FISTULAS
AB Background: Endoscopic treatment options for postsurgical intrathoracic leaks include injection of fibrin glue, clip application, and stent placement. Endoscopic vacuum-assisted Closure (E-VAC) may be an effective treatment option.
   Objective: To demonstrate that E-VAC is an effective endoscopic treatment option for Closure of major intrathoracic postsurgical leaks.
   Design and Setting: A prospective, single-center Study at an academic medical center.
   Patients: Eight consecutive patients with major intrathoracic postsurgical leaks.
   Interventions: Endoscopic placement of transnasal draining tubes, armed With a size-adjusted sponge at their distal end, in the necrotic anastomotic cavities, followed by continuous suction. Sponge and drainage were changed twice weekly. Patients were followed-up for 1.93 +/- 137 days.
   Main Outcome Measurement: Successful leak closure.
   Results: Successful Closure of leaks was achieved in 7 of 8 patients (88%) after a mean of 23 +/- 8 clays. A median of 7 endoscopic interventions was necessary. No major treatment-associated short-term or long-term (follow-up, 193 +/- 137 clays) complications were noted.
   Limitations: Small sample size, single-center study, and lack of randomization.
   Conclusion: E-VAC is an effective endoscopic treatment modality for major postsurgical intrathoracic leaks.
C1 [Wedemeyer, Jochen; Brangewitz, Mira; Kubicka, Stefan; Manns, Michael P.; Schneider, Andrea S.] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany.
   [Jackobs, Steffan; Winkler, Michael; Neipp, Michael; Klempnauer, Juergen] Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, D-30625 Hannover, Germany.
   [Neipp, Michael] Klinikum Itzehoe, Dept Gen Vasc & Visceral Surg, Itzehoe, Germany.
C3 Hannover Medical School; Hannover Medical School
RP Wedemeyer, J (通讯作者)，Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM wedemeyer.jochen@mh-hannover.de
RI Manns, Michael/AFG-3063-2022
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NR 26
TC 79
Z9 91
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
EI 1097-6779
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD FEB
PY 2010
VL 71
IS 2
BP 382
EP 386
DI 10.1016/j.gie.2009.07.011
PG 5
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 558VT
UT WOS:000274777200026
PM 19879566
DA 2026-07-24
ER
PT J
AU Boone, D
   Braitman, E
   Gentics, C
   Afthinos, J
   Latif, J
   Sordillo, E
   Todd, G
   Lantis, JC
AF Boone, Deva
   Braitman, Elissa
   Gentics, Cynthia
   Afthinos, John
   Latif, Jawad
   Sordillo, Emilia
   Todd, George
   Lantis, John C., II
TI Bacterial Burden and Wound Outcomes as Influenced by Negative Pressure
   Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL
AB Negative pressure wound therapy (NPWT) has consistently shown significant clinical benefits in wound healing, but the mechanisms are not fully elucidated. While a reduction in bacterial burden is one possible contributor, studies have shown mixed results in this regard. The present study used a porcine infected wound model to test the effect of NPWT on bacterial burden. Methods. Infected wounds (Pseudomonas aeruginosa, coagulase negative Staphylococcus, and Bacteroides fragilis) in a porcine model were treated with V.A.C.(R) therapy with the standard GranuFoam (TM) dressing, V.A.C. therapy with the GranuFoam Silver (R) dressing, or moist gauze for a period of 7 days with three dressing changes. Quantitative and semiquantitative bacterial cultures, histological samples, and digital photographs were taken at dressing changes. Results. The wounds continued to show gross and microscopic improvement when treated with standard NPWT and NPWT with silver compared to moist wound care controls. However, the bacterial burden in all wounds continued to increase and broadened to include local skin flora, which had been absent immediately after wounding. These increases in bacteria were not affected by the use of silver dressings. Conclusion. Negative pressure wound therapy with either standard NPWT foam or silver NPWT foam produced significant improvements in local wound appearance. This occurred despite a persistently high level of bacterial infection; thus, the improvement in healing of these infected wounds cannot be explained by a change in the bacterial burden.
C1 [Boone, Deva; Braitman, Elissa; Gentics, Cynthia; Afthinos, John; Latif, Jawad; Sordillo, Emilia; Todd, George; Lantis, John C., II] Columbia Univ, St Lukes Roosevelt Hosp, New York, NY 10025 USA.
C3 Columbia University; Mount Sinai Morningside; Mount Sinai West
RP Lantis, JC (通讯作者)，Columbia Univ, St Lukes Roosevelt Hosp, 1111 Amsterdam Ave,MU 208, New York, NY 10025 USA.
EM JLantis@chpnet.org
RI Sordillo, Emilia Mia/AAF-3012-2021
OI Sordillo, Emilia Mia/0000-0001-7787-3051
FU Nitric Bio, Inc (Bristol, Pa)
FX The facility performing this work was in part supported by an
   unrestricted grant from Nitric Bio, Inc (Bristol, Pa). The V.A.C.
   devices used for the study were provided by KCI (San Antonio, Tex).
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
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NR 11
TC 18
Z9 23
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2010
VL 22
IS 2
BP 32
EP 37
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 559NT
UT WOS:000274833000004
PM 25901723
DA 2026-07-24
ER
PT J
AU Riebe, E
   Ohlinger, R
   Thele, F
   Köhler, G
AF Riebe, Erik
   Ohlinger, Ralf
   Thele, Franziska
   Koehler, Guenter
TI Polypropylene Mesh Implantation in Combination With Vacuum-Assisted
   Closure in the Management of Metastatic or Locally Recurrent Vulvar
   Cancer Case Report and Review of Literature
SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
LA English
DT Article
DE Vulvar cancer; Vacuum-assisted closure; Mesh implantation;
   Inguinofemoral lymphadenectomy
ID SQUAMOUS-CELL CARCINOMA; LYMPH-NODE METASTASES; GROIN; IDENTIFICATION;
   DISSECTION; SURVIVAL; DISEASE; WOMEN; TRIAL
AB Background: Mesh reconstruction, especially in combination with vacuum-assisted closure, might improve healing and reduce the surgical morbidity of extensive inguinofemoral lymphadenectomy or extensive local resection in progressive cancer of the vulva.
   Cases: Radical vulvectomy combined with inguinofemoral lymphadenectomy was performed in 2 patients (P1, P2). The inguinofemoral wound bed was stabilized by polypropylene mesh implantation and sealed with vacuum closure system. In 1 patient with local recurrence of vulvar cancer (P3), local excision and stabilization of the wound were performed by mesh implantation.
   Conclusions: Mesh implantation fulfills 2 purposes: (1) it protects exposed vessels and the wound can be vacuum sealed; and (2) it stabilizes the surgical bed, permitting the required radical excision locally and inside the vascular compartment.
C1 [Riebe, Erik; Ohlinger, Ralf; Thele, Franziska; Koehler, Guenter] Ernst Moritz Arndt Univ Greifswald, Dept Gynecol & Obstet, D-17475 Greifswald, Germany.
C3 Universitat Greifswald
RP Riebe, E (通讯作者)，Ernst Moritz Arndt Univ Greifswald, Dept Gynecol & Obstet, Wollweberstr 1-3, D-17475 Greifswald, Germany.
EM erik.riebe@uni-greifswald.de
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NR 26
TC 10
Z9 11
U1 0
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1048-891X
EI 1525-1438
J9 INT J GYNECOL CANCER
JI Int. J. Gynecol. Cancer
PD JAN
PY 2010
VL 20
IS 1
BP 179
EP 183
DI 10.1111/IGC.0b013e3181c13343
PG 5
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA 559ZH
UT WOS:000274870800028
PM 20130520
DA 2026-07-24
ER
PT J
AU Argenta, LC
   Morykwas, MJ
   Mays, JJ
   Thompson, EA
   Hammon, JW
   Jordan, JE
AF Argenta, Louis C.
   Morykwas, Michael J.
   Mays, Jennifer J.
   Thompson, Edreca A.
   Hammon, John W.
   Jordan, James E.
TI Reduction of Myocardial Ischemia-Reperfusion Injury by Mechanical Tissue
   Resuscitation Using Sub-Atmospheric Pressure
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID TOPICAL NEGATIVE-PRESSURE; VACUUM-ASSISTED CLOSURE; CLINICAL
   IMPLICATIONS; CONSEQUENCES; GENERATION
AB P>Background: Reperfusion-induced injury after myocardial infarction is associated with a well-defined sequence of early and late cardiomyocyte death. Most present attempts to ameliorate this sequence focus on a single facet of the complex process in an attempt to salvage cardiomyocytes. We examined, as proof of concept, the effects of mechanical tissue resuscitation (MTR) with controlled negative pressure on myocardial injury following acute myocardial infarction. Methods: Anesthetized swine were subjected to 75 minutes of left coronary artery occlusion and three hours of reperfusion. Animals were assigned to one of three groups: (A) untreated control; treatment of involved myocardium for 180 minutes of MTR with (B) -50 mmHg, or (C) -125 mmHg. Results: All three groups were subjected to equivalent ischemic stress. Treatment of the ischemic area with MTR for 180 minutes significantly (p < 0.001) reduced infarct size (area of necrosis/area at risk) in both treatment groups compared to control: 9.3 +/- 1.8% (-50 mmHg) and 11.9 +/- 1.2% (-125 mmHg) versus 26.4 +/- 2.1% (control). Total area of cell death was reduced by 65% with -50 mmHg treatment and 55% in the -125 mmHg group. Conclusions: Treatment of ischemic myocardium with MTR, for a controlled period of time during reperfusion, successfully reduced the extent of myocardial death after acute myocardial infarction. These data provide evidence that MTR using subatmospheric pressure may be a simple, efficacious, nonpharmacological, mechanical strategy for decreasing cardiomyocyte death following myocardial infarction, which can be delivered in the operating room. (J Card Surg 2010;25:247-252).
C1 [Mays, Jennifer J.; Hammon, John W.; Jordan, James E.] Wake Forest Univ Hlth Sci, Dept Cardiothorac Surg, Winston Salem, NC USA.
   [Argenta, Louis C.; Morykwas, Michael J.; Thompson, Edreca A.] Wake Forest Univ Hlth Sci, Dept Plast & Reconstruct Surg, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest University School of Medicine; Wake
   Forest University; Wake Forest University School of Medicine
RP Argenta, LC (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM largenta@wfubmc.edu
OI Morykwas, Michael/0009-0001-5547-5172
FU Cheek Foundation Endowment of the Department of Plastic and
   Reconstructive Surgery of Wake Forest University; RepaiRx Laboratories
   of the Department of Plastic and Reconstructive Surgery at Wake Forest
   University Medical Center
FX This project was funded in part by the Cheek Foundation Endowment of the
   Department of Plastic and Reconstructive Surgery of Wake Forest
   University and by the RepaiRx Laboratories of the Department of Plastic
   and Reconstructive Surgery at Wake Forest University Medical Center.
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NR 19
TC 6
Z9 7
U1 0
U2 4
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0886-0440
J9 J CARDIAC SURG
JI J. Card. Surg.
PD MAR
PY 2010
VL 25
IS 2
BP 247
EP 252
DI 10.1111/j.1540-8191.2009.00972.x
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 563PM
UT WOS:000275145200036
PM 20492032
DA 2026-07-24
ER
PT J
AU Weston, C
AF Weston, C.
TI The Science behind Topical Negative Pressure Therapy
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE Topical negative pressure therapy; VAC (R) Therapy; matrix
   metalloproteinase; cytokines; microvascular blood flow; perfusion; cell
   strain
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; SUBATMOSPHERIC PRESSURE;
   CELL-SHAPE; METALLOPROTEINASES; PROGRESSION; SKIN
AB Topical negative pressure therapy (TNP) is an established part of modern wound healing. With an increasing choice in TNP providers, understanding the differing modes of action, the biochemical and biophysical effects on the Wound at a microscopic and macroscopic level, Plus the role of the interface dressings. will aid the clinician in planning C! it clear goal of therapy. This article reviews the scientific evidence for TNP to date and explores each mechanism of action and the implications for wound healing and patient Outcomes.
C1 KCI Med Ltd, No Europe, Oxford OX5 1GF, England.
RP Weston, C (通讯作者)，KCI Med Ltd, No Europe, KCI House, Oxford OX5 1GF, England.
EM cweston@kci-medical.com
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NR 35
TC 3
Z9 4
U1 0
U2 2
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD FEB
PY 2010
VL 110
IS 1
BP 19
EP 27
DI 10.1080/00015458.2010.11680559
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 570EF
UT WOS:000275654000007
PM 20306904
DA 2026-07-24
ER
PT J
AU Wedemeyer, J
   Helfritz, FA
   Brangewitz, M
   Winkler, M
   Manns, MP
   Schneider, A
AF Wedemeyer, J.
   Helfritz, F. A.
   Brangewitz, M.
   Winkler, M.
   Manns, M. P.
   Schneider, A.
TI Endoscopic Vacuum Assisted Closure for Intestinal Leakages
SO ENDOSKOPIE HEUTE
LA German
DT Article
DE anastomotic leakage; stent; endoscopic vacuum assisted closure
ID ESOPHAGEAL ANASTOMOTIC LEAKS; EXPANDING PLASTIC STENTS; PRESSURE WOUND
   THERAPY; GASTRIC-CARCINOMA; PERFORATIONS; MULTICENTER; EXPERIENCE;
   MANAGEMENT; SURGERY
AB Anastomotic leakage in the upper and lower intestinal tract is associated with high morbidity and mortality. Endoscopic vacuum assisted closure (E-V.A.C.) is a new innovative endoscopic therapeutic option. E-V.A.C. transfers the positive effects of vacuum assisted closure (V.A.C.) on infected cutaneous Wounds to infected cavities that can only be reached endoscopically. For the treatment of rectal insufficiency, a commercially available vacuum system (Endosponge (R)) is available. In the upper gastrointestinal tract the method has been applied successfully for the treatment of intrathoracic anastomotic leakages. E-V.A.C. might be an important alternative to stent placement in intrathoracic anastomotic leakage. Additional indications for the application of E-V.A.C. are expected to be developed within the near future.
C1 [Wedemeyer, J.; Brangewitz, M.; Manns, M. P.; Schneider, A.] Hannover Med Sch, Klin Gastroenterol Hepatol & Endokrinol, D-30625 Hannover, Germany.
   [Helfritz, F. A.; Winkler, M.] Hannover Med Sch, Klin Allgemein Viszeral & Transplantat Chirurg, D-30625 Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School
RP Wedemeyer, J (通讯作者)，Hannover Med Sch, Klin Gastroenterol Hepatol & Endokrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM wedemeyer.jochen@mh-hannover.de
RI Manns, Michael/AFG-3063-2022
CR Choudhury SH, 2001, AM J ROENTGENOL, V176, P161, DOI 10.2214/ajr.176.1.1760161
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NR 28
TC 1
Z9 1
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0933-811X
EI 1439-2577
J9 ENDOSKOPIE HEUTE
JI Endoskopie Heute
PD MAR
PY 2010
VL 23
IS 1
BP 41
EP 45
DI 10.1055/s-0030-1247247
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 571WF
UT WOS:000275785900009
DA 2026-07-24
ER
PT J
AU Tokuda, Y
   Teranishi, K
   Morita, S
   Yamaguchi, K
   Takeuchi, E
AF Tokuda, Yoshiyuki
   Teranishi, Katsuhito
   Morita, Shin
   Yamaguchi, Kazuo
   Takeuchi, Eiji
TI Pneumopericardial Tamponade in a Patient With Partial Sternal Dehiscence
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID CARDIAC-TAMPONADE
AB We present a rare case of sudden pneumopericardial tamponade in a patient with partial sternal dehiscence after cardiac surgery. Urgent decompression was needed in the management of the condition. Vacuum-assisted closure therapy was also used to prevent the problem from recurring. When there is acute hemodynamic deterioration in a patient with sternal wound dehiscence, pneumopericardial tamponade should be considered as a possible complication. (Ann Thorac Surg 2010;89:1291-2) (C) 2010 by The Society of Thoracic Surgeons
C1 [Tokuda, Yoshiyuki; Teranishi, Katsuhito; Morita, Shin; Yamaguchi, Kazuo; Takeuchi, Eiji] Natl Hosp Org, Nagoya Med Ctr, Dept Cardiovasc Surg, Naka Ku, Aichi 4600001, Japan.
C3 Nagoya Medical Center
RP Tokuda, Y (通讯作者)，Natl Hosp Org, Nagoya Med Ctr, Dept Cardiovasc Surg, Naka Ku, 4-1-1 Sannomaru, Aichi 4600001, Japan.
EM tokuda@mxb.mesh.ne.jp
RI Tokuda, Yoshiyuki/B-8432-2016; Takeuchi, Eiji/ABC-6741-2021
OI Tokuda, Yoshiyuki/0000-0001-6405-8752; 
CR Benedík J, 2002, EUR J CARDIO-THORAC, V21, P585, DOI 10.1016/S1010-7940(01)01159-9
   CUMMINGS RG, 1984, ANN THORAC SURG, V37, P511, DOI 10.1016/S0003-4975(10)61146-0
   GAMEL AE, 1994, ACTA PAEDIATR, V83, P1220
   Karoui M, 2008, NEW ENGL J MED, V359, pE16, DOI 10.1056/NEJMicm074422
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   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
NR 6
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD APR
PY 2010
VL 89
IS 4
BP 1291
EP 1292
DI 10.1016/j.athoracsur.2009.09.022
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 573CK
UT WOS:000275885800053
PM 20338363
OA Bronze
DA 2026-07-24
ER
PT J
AU Utz, ER
   Elster, EA
   Tadaki, DK
   Gage, F
   Perdue, PW
   Forsberg, JA
   Stojadinovic, A
   Hawksworth, JS
   Brown, TS
AF Utz, Edward R.
   Elster, Eric A.
   Tadaki, Douglas K.
   Gage, Frederick
   Perdue, Philip W.
   Forsberg, Jonathan A.
   Stojadinovic, Alexander
   Hawksworth, Jason S.
   Brown, Trevor S.
TI Metalloproteinase Expression is Associated with Traumatic Wound Failure
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Luminex; MMP-2; MMP-3; MMP-7; effluent; multiplex; dehiscence; acute
   wound; VAC
ID OPERATION IRAQI FREEDOM; GINGIVAL CREVICULAR FLUID; MATRIX
   METALLOPROTEINASES; EXTREMITY WOUNDS; ENDURING FREEDOM; THERAPY; BLAST;
   MECHANISMS; INJURIES; BIOLOGY
AB Background. Matrix metalloproteinases (MMPs) are crucial in the inflammatory and remodeling phases of wound healing. We previously reported the correlation between pro-inflammatory cytokines and timing of successful combat-wound closure. We now extend our studies to investigate the correlation between wound-remodeling MMP expression and wound healing.
   Methods. Thirty-eight wounds in 25 patients with traumatic extremity combat wounds were prospectively studied. Surgical debridement with vacuum-assisted closure (VAC) device application was repeated every 48 to 72h until surgical wound closure. Wound effluent and patient serum were collected at each wound debridement and analyzed for five matrix metalloproteinases using the Luminex multiplex system; Millipore Corp, Billerica, MA. The primary outcome was wound healing within 30 d of definitive wound closure. Impairment was defined as delayed wound closure (>21 d from injury) or wound dehiscence. MMP expression was compared between impaired and normal healing wounds.
   Results. Elevated levels of serum MMP-2 and MMP-7 and reduced levels of effluent MMP3 were seen in impaired wounds (n = 9) compared with wounds that healed (n = 29; P<0.001). Receiver operating characteristic (ROC) curve analysis yielded area-under-the-curve (AUC) of 0.744, 0.783, and 0.805, respectively.
   Conclusions. Impaired wound healing is characterized by pro-inflammatory MMP-2 and MMP-7. Serum and effluent concentrations of MMP-2, MMP-3, and MMP-7 can effectively predict the outcome of traumatic war wounds and can potentially provide decision-supportive, objective evidence for the timing of wound closure. Published by Elsevier Inc.
C1 [Utz, Edward R.; Elster, Eric A.; Tadaki, Douglas K.; Gage, Frederick; Forsberg, Jonathan A.; Hawksworth, Jason S.; Brown, Trevor S.] USN, Med Res Ctr, Regenerat Med Dept, Silver Spring, MD 20910 USA.
   [Stojadinovic, Alexander; Hawksworth, Jason S.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
   [Utz, Edward R.; Elster, Eric A.; Tadaki, Douglas K.; Forsberg, Jonathan A.; Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
   [Elster, Eric A.; Perdue, Philip W.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA.
   [Forsberg, Jonathan A.] Walter Reed Natl Mil Med Ctr, Integrated Dept Orthopaed & Rehabil, Bethesda, MD USA.
C3 United States Department of Defense; United States Navy; Walter Reed
   National Military Medical Center; United States Department of Defense;
   United States Army; Uniformed Services University of the Health Sciences
   - USA; Walter Reed National Military Medical Center; Walter Reed
   National Military Medical Center
RP Brown, TS (通讯作者)，USN, Med Res Ctr, Regenerat Med Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Trevor.Brown@med.navy.mil
RI Tadaki, Douglas/B-1623-2008; Forsberg, Jonathan/K-2116-2012; Brown,
   Trevor/F-7392-2015; Elster, Eric/G-2332-2010
OI Forsberg, Jonathan/0000-0003-3835-0615; Stojadinovic,
   Alexander/0000-0002-2829-8967; Brown, Trevor/0000-0001-7042-785X;
   Elster, Eric/0000-0002-0981-2748
FU U.S. Navy Bureau of Medicine and Surgery [PE 0604771 N]; Alpha Omega
   Alpha Carolyn L. Kuckein Student Research Fellowship
FX The multidisciplinary care of these patients would not have been
   possible without the dedicated efforts of everyone at NNMC. Both
   civilian and military personnel have rendered skilled and compassionate
   care for these casualties. All of our efforts are dedicated to those who
   have been placed in harm's way for the good of our nation. This effort
   was supported (in part) by the U.S. Navy Bureau of Medicine and Surgery
   under the Medical Development Program (PE 0604771 N) and in part by an
   Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship.
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NR 27
TC 70
Z9 84
U1 0
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD APR
PY 2010
VL 159
IS 2
BP 633
EP 639
DI 10.1016/j.jss.2009.08.021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 575MU
UT WOS:000276072000005
PM 20056248
DA 2026-07-24
ER
PT J
AU Ganacias-Acuna, EF
AF Ganacias-Acuna, Edna F.
TI Active Leptospermum Honey and Negative Pressure Wound Therapy for
   Nonhealing Postsurgical Wounds
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
ID OCCLUSION
C1 Methodist Dallas Med Ctr, Wound Care & Hyperbar Clin, Dallas, TX USA.
RP Ganacias-Acuna, EF (通讯作者)，Methodist Dallas Med Ctr, Wound Care & Hyperbar Clin, Dallas, TX USA.
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NR 14
TC 9
Z9 9
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAR
PY 2010
VL 56
IS 3
BP 10
EP +
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 576XL
UT WOS:000276183300003
PM 20560236
DA 2026-07-24
ER
PT J
AU Borgquist, O
   Ingemansson, R
   Malmsjö, M
AF Borgquist, Ola
   Ingemansson, Richard
   Malmsjo, Malin
TI The Effect of Intermittent and Variable Negative Pressure Wound Therapy
   on Wound Edge Microvascular Blood Flow
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE in vivo; controlled study; negative pressure wound therapy; blood flow;
   pressure levels
ID VACUUM-ASSISTED CLOSURE; MECHANISMS; STRESS
AB Negative pressure wound therapy (NPWT) alters wound edge microvascular blood flow. Some preclinical data suggest that cycling between low and high negative pressure may be more beneficial than continuous NPWT. The purpose of this in vivo study was to compare the effect of intermittent negative pressure (cycled either from 0 to -75 or to -125 mm Hg) and variable negative pressure (cycled from -10 to -75 or -125 mm Hg or from -45 to -75 or -125 mm Hg) on wound edge microvascular blood flow. Using a peripheral wound model (n = 8 domestic 70-kg pigs), intermittent and variable NPWT was applied to surgically created wounds (5 cm diameter, 2 cm. depth) for five cycles of 5 minutes of high and 2 minutes of low pressure. Blood flow was measured using laser Doppler velocimetry in subcutaneous and muscle tissue at 0.5 and 2.5 cm from the wound edge. When NPWT was applied, blood flow decreased an average of 29% +/- 2% in muscle tissue and 22 % +/- 4% in subcutaneous tissue at -75 mm Hg at 0.5 cm from the wound edge and increased an average of 20% +/- 6% for -75 mm Hg at 2.5 cm from the wound edge. Blood flow changed repeatedly when negative pressure was cycled. Large gradients between the cycled pressures (eg, -10 to -75 mm Hg) resulted in greater blood flow alterations than smaller (eg, -45 to -75 mm Hg) gradients. Blood flow alternations were similar between low-pressure settings of -10 mm Hg (variable NPWT) and 0 mm Hg (intermittent NPWT) and between high-pressure settings of -75 or -125 mm Hg. Both intermittent and variable NPWT result in a beneficial combination of increased blood flow, known to facilitate oxygenation and nutrient supply, and decreased blood flow, known to stimulate angiogenesis and granulation tissue formation. Cycling the negative pressure may be especially advantageous when treating poorly vascularized tissue. In cases where intermittent therapy causes patient discomfort, variable therapy may be superior.
C1 [Borgquist, Ola; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University
RP Malmsjö, M (通讯作者)，A13, S-22184 Lund, Sweden.
EM malin.malmsjo@gmail.com
RI ; Borgquist, Ola/AAO-6451-2020
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953
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   Quinn TP, 2002, AM J PHYSIOL-LUNG C, V282, pL897, DOI 10.1152/ajplung.00044.2001
   Ramnarine IR, 2002, EUR J CARDIO-THORAC, V22, P1029, DOI 10.1016/S1010-7940(02)00562-6
   Rivilis I, 2002, AM J PHYSIOL-HEART C, V283, pH1430, DOI 10.1152/ajpheart.00082.2002
   URSCHEL JD, 1988, BRIT J PLAST SURG, V41, P182, DOI 10.1016/0007-1226(88)90049-5
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
   ZOGRAFOS GC, 1992, ANN SURG, V215, P266, DOI 10.1097/00000658-199203000-00011
NR 30
TC 52
Z9 61
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAR
PY 2010
VL 56
IS 3
BP 60
EP +
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 576XL
UT WOS:000276183300010
PM 20368675
DA 2026-07-24
ER
PT J
AU Huston, TL
   Grant, RT
AF Huston, Tara L.
   Grant, Robert T.
TI Abdominal wall gossypiboma
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Vacuum assisted closure device; Abdominoplasty; Bariatric body
   contouring; Gossypiboma
AB A 71-year-old woman, one year following a fleur-de-lis abdominoplasty and incisional hernia repair, presented with two chronic, draining peri-umbilical sinuses. Her immediate postoperative course was complicated by a superficial surgical site infection with central skin breakdown that was treated with vacuum assisted closure (VAC). After the wound had closed completely, two midline sinus tracts developed. A CT scan demonstrated an 8 x 3 x 1.6 cm thick-walled collection along the anterior abdominal wall containing numerous air bubbles. Surgical debridement revealed a cavity containing an 8 x 3 x 1.6 cm block of well incorporated VAC foam. With the increasing clinical use of VAC wound therapy, this image serves as an important reminder to include gossypiboma in the differential diagnosis for patients with chronic wound problems who have previously received VAC treatment. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Huston, Tara L.; Grant, Robert T.] New York Presbyterian Hosp, New York, NY 10065 USA.
C3 Cornell University; Weill Cornell Medicine; NewYork-Presbyterian
   Hospital
RP Huston, TL (通讯作者)，New York Presbyterian Hosp, 525 E 68th St,K707, New York, NY 10065 USA.
EM taa9002@nyp.org
CR Gawande AA, 2003, NEW ENGL J MED, V348, P229, DOI 10.1056/NEJMsa021721
   Saeed Musab U, 2007, Int J Low Extrem Wounds, V6, P153, DOI 10.1177/1534734607305597
NR 2
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAY
PY 2010
VL 63
IS 5
BP E463
EP E464
DI 10.1016/j.bjps.2009.07.034
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 577CW
UT WOS:000276199700033
PM 19683975
DA 2026-07-24
ER
PT J
AU Dian, D
   Bodungen, V
   Himsl, I
   Drinovac, V
   Mylonas, I
   Sommer, H
   Friese, K
AF Dian, Darius
   Bodungen, Vera
   Himsl, Isabelle
   Drinovac, Visnja
   Mylonas, Ioannes
   Sommer, Harald
   Friese, Klaus
TI Worldwide first experiences with vacuum-assisted closure as alternative
   treatment method to repair defects of an extended thoracic wall
   recurrence of breast cancer
SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS
LA English
DT Article
DE Breast; Cancer; Recurrence; Vacuum-assisted closure (VAC)
ID PROSPECTIVE RANDOMIZED-TRIAL; WOUND THERAPY; RECONSTRUCTION
AB Loco-regional recurrences of the breast cancer are associated with a bad prognosis. Often costly autologous-tissue treatment as a surgery aiming at repairing the defects is necessary.
   Four female patients were treated with the vacuum-assisted closure (VAC)-system in context with the recurrence resection. In all cases a primary local masking was not possible.
   In the described cases the wounds healed well during the post-operative phase. There occurred no problems either during the radiation treatment or during chemotherapy in the case of lying VAC-Systems.
   Using vacuum-assisted wound closure one can avoid autologous-tissue treatment in the case of extensive loco-regional recurrences.
C1 [Dian, Darius] Univ Frauenklin Munchen, D-80337 Munich, Germany.
   [Dian, Darius; Bodungen, Vera; Himsl, Isabelle; Drinovac, Visnja; Mylonas, Ioannes; Sommer, Harald; Friese, Klaus] Ludwig Maximillians Univ Hosp, Dept Obstet & Gynaecol, Munich, Germany.
C3 University of Munich; University of Munich
RP Dian, D (通讯作者)，Univ Frauenklin Munchen, Campus Innenstadt,Maistr 11, D-80337 Munich, Germany.
EM darius.dian@med.uni-muenchen.de
OI Dian, Darius/0000-0003-0981-4118
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Dian D, 2006, GEBURTSH FRAUENHEILK, V66, P469, DOI 10.1055/s-2006-924112
   DIAN D, 2009, MANUAL MAMMAKARZINOM, P217
   Dian D, 2008, ARCH GYNECOL OBSTET, V277, P127, DOI 10.1007/s00404-007-0432-3
   Dian Darius, 2007, Archives of Gynecology and Obstetrics, V275, P445, DOI 10.1007/s00404-006-0270-8
   Dian D, 2009, ARCH GYNECOL OBSTET, V280, P539, DOI 10.1007/s00404-009-0954-y
   Dian D, 2009, ARCH GYNECOL OBSTET, V279, P23, DOI 10.1007/s00404-008-0662-z
   Flack S, 2008, J Wound Care, V17, P71
   HAYES D, 2008, OVERVIEW TREATMENT L
   Immer FF, 2005, ANN THORAC SURG, V80, P957, DOI 10.1016/j.athoracsur.2005.03.035
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mouës CM, 2007, J PLAST RECONSTR AES, V60, P672, DOI 10.1016/j.bjps.2006.01.041
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Polykandriotis E, 2006, ZBL CHIR, V131, pS36, DOI 10.1055/s-2006-921476
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   Wondberg D, 2008, WORLD J SURG, V32, P2724, DOI 10.1007/s00268-008-9762-y
NR 17
TC 9
Z9 12
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0932-0067
J9 ARCH GYNECOL OBSTET
JI Arch. Gynecol. Obstet.
PD MAY
PY 2010
VL 281
IS 5
BP 927
EP 932
DI 10.1007/s00404-009-1277-8
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 578AH
UT WOS:000276265100023
PM 19921232
DA 2026-07-24
ER
PT J
AU Bischoff, G
   Muehling, B
   Orend, K
   Bischoff, M
   Sunder-Plassmann, L
AF Bischoff, G.
   Muehling, B.
   Orend, K.
   Bischoff, M.
   Sunder-Plassmann, L.
TI A New Treatment Concept for Bronchial Stump Insufficiency
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE vacuum therapy; bronchial stump; insufficiency; bronchopulmonary fistula
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND INFECTIONS; DEFINITIVE CLOSURE;
   NEGATIVE-PRESSURE; SEALING TECHNIQUE; TISSUE DEFECTS; THERAPY; SURGERY;
   MEDIASTINITIS; MANAGEMENT
AB Introduction: Bronchial stump insufficiency (BSI) remains one of the most feared complications with an incidence of 0-12% in the literature.
   Patients and Method: The present retrospective study reviewed the medical records of 11 patients with BSI. Patients were divided into two groups, depending on treatment. In group A, 5 patients were treated initially unsuccessfully using other therapeutic procedures such pectoralis flap transposition, omentum majus transposition and fibrin glue applications and subsequently treated successfully with vacuum therapy (VT). In 6 patients (group B), only VT (a combination of bronchial suture, thoracoplasty, latissimus muscle transposition and VT) was performed. VT represents a closed dressing system allowing moist wound treatment in full contact with the wound surface as well as protection against contamination with nosocomial pathogens by means of continuous drainage of wound secretions.
   Results: Of the 11 patients reviewed in this study, closure of the bronchial stump with VT was achieved in 8 patients. Of the 8 patients with successful closure of the bronchial stump, 4 patients were in group A and 4 in group B.
   Conclusion: Based on this preliminary experience, the combination of bronchial suture, thoracoplasty, latissimus muscle transposition and VT appears to be a promising concept for the management of bronchial stump insufficiency.
C1 [Bischoff, G.] Univ Ulm, Dept Thorac & Vasc Surg, D-89075 Ulm, Germany.
   Univ Ulm, Dept Trauma Hand Plast & Reconstruct Surg, D-89075 Ulm, Germany.
C3 Ulm University; Ulm University
RP Bischoff, G (通讯作者)，Univ Ulm, Dept Thorac & Vasc Surg, Steinhovelstr 9, D-89075 Ulm, Germany.
EM gisela.bischoff@uniklinik-ulm.de
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NR 34
TC 2
Z9 2
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD APR
PY 2010
VL 58
IS 3
BP 169
EP 174
DI 10.1055/s-0029-1240780
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 580BD
UT WOS:000276420900007
PM 20376728
DA 2026-07-24
ER
PT J
AU Byrnside, V
   Glasgow, M
   Gurunluoglu, R
AF Byrnside, Valerie
   Glasgow, Mark
   Gurunluoglu, Raffi
TI The Vacuum-Assisted Closure in Treating Craniofacial Wounds
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID NECROTIZING FASCIITIS; MANAGEMENT; THERAPY; FACE
C1 [Gurunluoglu, Raffi] Denver Hlth Med Ctr, Dept Plast & Reconstruct Surg, Denver, CO 80204 USA.
   [Byrnside, Valerie; Glasgow, Mark] Denver Hlth Med Ctr, Dept Oral & Maxillofacial Surg, Denver, CO 80204 USA.
C3 Denver Health Medical Center; Denver Health Medical Center
RP Gurunluoglu, R (通讯作者)，Denver Hlth Med Ctr, Dept Plast & Reconstruct Surg, 777 Bannock St, Denver, CO 80204 USA.
EM raffi.gurunluoglu@dhha.org
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   VAC GRANUFOAM DRESSI
   VAC VACUUM ASSISTED
NR 23
TC 15
Z9 16
U1 1
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
EI 1531-5053
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD APR
PY 2010
VL 68
IS 4
BP 935
EP 942
DI 10.1016/j.joms.2009.09.113
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 582EO
UT WOS:000276579200039
PM 20307779
DA 2026-07-24
ER
PT J
AU Hinck, D
   Franke, A
   Gatzka, F
AF Hinck, Daniel
   Franke, Axel
   Gatzka, Friedrich
TI Use of Vacuum-Assisted Closure Negative Pressure Wound Therapy in
   Combat-Related Injuries-Literature Review
SO MILITARY MEDICINE
LA English
DT Article
ID OPERATION-IRAQI-FREEDOM; OPEN TIBIAL FRACTURES; SOFT-TISSUE INJURIES;
   WAR WOUNDS; EXTREMITY WOUNDS; ENDURING FREEDOM; GROWTH-FACTORS;
   MANAGEMENT; INFECTIONS; CARE
AB Despite surgical and technological advances, managing combat-related injuries remains challenging both within and outside of the war theater. Unique characteristics of a war theater such as environmental contamination, varying evacuation procedures, and differing levels of medical care, add to the complexity. The advent of body armor has increased blast survival rates and soldiers are surviving with increasingly mangled limbs that require lengthy. multifaceted care. An inherent high risk of infection contraindicates immediate closure for these wounds. There is growing reported use of negative pressure wound therapy with reticulated open-cell foam (NPWT/ROCF) as delivered by vacuum-assisted closure (VAC) therapy (KCI Licensing Inc., San Antonio, TX) as an adjunctive therapy in these open sort-tissue corn hat wounds. This review evaluates the efficacy of NPWT/ROCF for adjunctive treatment of wartime wounds. Following a literature review, data are summarized and presented.
C1 [Hinck, Daniel; Gatzka, Friedrich] German Mil Hosp Hamburg, Dept Gen Thorax & Visceral Surg, Sect Vasc, Dept Surg, D-22049 Hamburg, Germany.
   [Franke, Axel] German Mil Hosp Koblenz, Dept Trauma Surg, D-56072 Koblenz, Germany.
RP Hinck, D (通讯作者)，German Mil Hosp Hamburg, Dept Gen Thorax & Visceral Surg, Sect Vasc, Dept Surg, Lesserstr 180, D-22049 Hamburg, Germany.
OI Hinck, Daniel/0000-0002-1226-4244
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   Suljagic Vesna, 2003, Vojnosanit Pregl, V60, P443, DOI 10.2298/VSP0304443S
   Ullmann Y, 2006, ANN PLAS SURG, V56, P401, DOI 10.1097/01.sap.0000201552.81612.68
   Vertrees A, 2008, J AM COLL SURGEONS, V207, P801, DOI 10.1016/j.jamcollsurg.2008.08.014
   Wagner S, 2003, WOUND REPAIR REGEN, V11, P253, DOI 10.1046/j.1524-475X.2003.11404.x
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NR 51
TC 43
Z9 55
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2010
VL 175
IS 3
BP 173
EP 181
DI 10.7205/MILMED-D-09-00075
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 582GT
UT WOS:000276585400009
PM 20358706
OA Bronze
DA 2026-07-24
ER
PT J
AU Romero, P
   Kessler, M
   Springer, W
   Holland-Cunz, S
AF Romero, P.
   Kessler, M.
   Springer, W.
   Holland-Cunz, S.
TI Combined IntegraA® and vacuum-assisted therapy in premature infants - A
   case report of secondary wound closure for soft tissue necrosis of the
   lower extremity
SO MONATSSCHRIFT KINDERHEILKUNDE
LA German
DT Article
DE Artificial skin; Integra (R); Soft tissue necrosis; Vacuum-assisted
   closure; Children
ID BURN INJURY
AB The authors report the case of a premature infant who developed large-area skin and soft tissue necrosis as the result of a circulatory disorder in the right leg after thrombosis of the right femoral artery. After necrosectomy and simultaneous IntegraA (R) and vacuum-assisted therapy, split-thickness skin grafts were successfully used to cover the soft tissue defect. The authors report, for the first time, the difficulties involved and their experience with secondary wound closure in hypoperfused soft tissue in a premature infant.
C1 [Romero, P.; Kessler, M.; Holland-Cunz, S.] Univ Klinikum Heidelberg, Chirurg Klin, Sekt Kinderchirurg, D-69120 Heidelberg, Germany.
   [Springer, W.] Univ Klinikum Heidelberg, Zentrum Kinder & Jugendmed, Abt Padiatr Kardiol, D-69120 Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg
RP Romero, P (通讯作者)，Univ Klinikum Heidelberg, Chirurg Klin, Sekt Kinderchirurg, Neuenheimer Feld 110, D-69120 Heidelberg, Germany.
EM Philipp.Romero@med.uni-heidelberg.de
CR Berger A, 2000, CHIRURG, V71, P558, DOI 10.1007/s001040050856
   BURKE JF, 1981, ANN SURG, V194, P413, DOI 10.1097/00000658-198110000-00005
   GROSSE MP, 2008, THESIS U REGENSBURG
   Khan MR, 2007, EUR J PLAST SURG, V30, P101, DOI 10.1007/s00238-007-0160-8
   Lee LF, 2008, PLAST RECONSTR SURG, V121, P1256, DOI 10.1097/01.prs.0000304237.54236.66
   Martinez L, 2002, Cir Pediatr, V15, P97
   Rennekampff HO, 2009, UNFALLCHIRURG, V112, P543, DOI 10.1007/s00113-009-1655-5
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NR 9
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0026-9298
EI 1433-0474
J9 MONATSSCHR KINDERH
JI Mon.schr. Kinderheilkd.
PD APR
PY 2010
VL 158
IS 4
BP 384
EP 387
DI 10.1007/s00112-009-2145-0
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 584AX
UT WOS:000276723500014
DA 2026-07-24
ER
PT J
AU Canavese, F
   Krajbich, JI
AF Canavese, Federico
   Krajbich, Joseph I.
TI Use of vacuum assisted closure in instrumented spinal deformities for
   children with postoperative deep infections
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE VAC therapy; deep wound infection; spinal deformity
ID WOUND CONTROL; MANAGEMENT; ADULTS; FUSION; SOFT
AB Background: Postoperative deep infections are relatively common in children with instrumented spinal deformities, whose healing potential is somewhat compromised. Children with underlying diagnosis of cerebral palsy, spina bifida and other chronic debilitating conditions are particularly susceptible. Vacuum-assisted closure (VAC) is a newer technique to promote healing of wounds resistant to treatment by established methods. This article aims to review the efficacy of the VAC system in the treatment of deep spinal infections following spinal instrumentation and fusion in children and adolescents. Materials and Methods: We reviewed 33 patients with deep postoperative surgical site infection treated with wound VAC technique. We reviewed clinical and laboratory data, including the ability to retain the spinal hardware, loss of correction and recurrent infections. Results : All patients successfully completed their wound VAC treatment regime. None had significant loss of correction and one had persistent infection requiring partial hardware removal. The laboratory indices normalized in all but three patients. Conclusions: Wound VAC technique is a useful tool in the armamentarium of the spinal surgeon dealing with patients susceptible to wound infections, especially those with neuromuscular diseases. It allows for retention of the instrumentation and maintenance of the spinal correction. It is reliable and easy to use.
C1 [Canavese, Federico; Krajbich, Joseph I.] Shriners Hosp Children, Dept Orthoped, Portland, OR 97239 USA.
RP Canavese, F (通讯作者)，Shriners Hosp Children, Dept Orthoped, 3101 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM canavese_federico@yahoo.fr
OI CANAVESE, Federico/0000-0002-6114-5372
CR ABBEY DM, 1995, J SPINAL DISORD, V8, P278, DOI 10.1097/00002517-199508040-00003
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NR 25
TC 10
Z9 10
U1 0
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD APR-JUN
PY 2010
VL 44
IS 2
BP 177
EP 183
DI 10.4103/0019-5413.62067
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 586AM
UT WOS:000276873100008
PM 20419005
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Fong, KD
   Hu, D
   Eichstadt, S
   Gupta, DM
   Pinto, M
   Gurtner, GC
   Longaker, MT
   Lorenz, HP
AF Fong, Kenton D.
   Hu, Dean
   Eichstadt, Shaundra
   Gupta, Deepak M.
   Pinto, Moshe
   Gurtner, Geoffrey C.
   Longaker, Michael T.
   Lorenz, H. Peter
TI The SNaP System: Biomechanical and Animal Model Testing of a Novel
   Ultraportable Negative-Pressure Wound Therapy System
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; STATE
AB Background: Negative-pressure wound therapy is traditionally achieved by attaching an electrically powered pump to a sealed wound bed and applying subatmospheric pressure by means of gauze or foam. The Smart Negative Pressure (SNaP) System (Spiracur, Inc., Sunnyvale, Calif.) is a novel ultraportable negative-pressure wound therapy system that does not require an electrically powered pump.
   Methods: Negative pressure produced by the SNaP System, and a powered pump, the wound vacuum-assisted closure advanced-therapy system (Kinetic Concepts, Inc., San Antonio, Texas), were compared in vitro using bench-top pressure sensor testing and microstrain and stress testing with pressure-sensitive film and micro computed tomographic scan analysis. In addition, to test in vivo efficacy, 10 rats underwent miniaturized SNaP (mSNaP) device placement on open wounds. Subject rats were randomized to a system activation group (approximately 125 mmHg) or a control group (atmospheric pressure). Wound measurements and histologic data were collected for analysis.
   Results: Bench measurement revealed nearly identical negative-pressure delivery and mechanical strain deformation patterns between both systems. Wounds treated with the mSNaP System healed faster, with decreased wound size by postoperative day 7 (51 percent versus 12 percent reduction; p < 0.05) and had more rapid complete reepithelialization (21 days versus 32 days; p < 0.05). The mSNaP device also induced robust granulation tissue formation.
   Conclusions: The SNaP System and an existing electrically powered negative-pressure wound therapy system have similar biomechanical properties and functional wound-healing benefits. The potential clinical efficacy of the SNaP device for the treatment of wounds is supported. (Plast. Reconstr. Surg. 125: 1362, 2010.)
C1 [Lorenz, H. Peter] Stanford Univ, Sch Med, Div Plast & Reconstruct Surg, Dept Surg, Stanford, CA 94305 USA.
   Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA.
C3 Stanford University; Stanford University
RP Lorenz, HP (通讯作者)，Stanford Univ, Sch Med, Div Plast & Reconstruct Surg, Dept Surg, 770 Welch Rd,Suite 400, Stanford, CA 94305 USA.
EM plorenz@stanford.edu
OI Longaker, Michael/0000-0003-1430-8914
FU Spiracur; Oak Foundation; Hagey Laboratory for Pediatric Regenerative
   Medicine
FX This work was supported by Spiracur, the Oak Foundation, and the Hagey
   Laboratory for Pediatric Regenerative Medicine. Portions of the
   experiment (micro computed tomographic strain evaluation) were performed
   at the Stanford Center for Innovation in In Vivo Imaging with
   collaboration from Dr. Timothy Doyle (Stanford Center for Innovation in
   In Vivo Imaging). Spiracur and SNaP are trademarks of Spiracur, Inc. All
   rights reserved.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 10
TC 29
Z9 30
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAY
PY 2010
VL 125
IS 5
BP 1362
EP 1371
DI 10.1097/PRS.0b013e3181d62b25
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 586EW
UT WOS:000276886600008
PM 20440156
DA 2026-07-24
ER
PT J
AU Baillot, R
   Cloutier, D
   Montalin, L
   Côté, L
   Lellouche, F
   Houde, C
   Gaudreau, G
   Voisine, P
AF Baillot, Richard
   Cloutier, Daniel
   Montalin, Livia
   Cote, Louise
   Lellouche, Francois
   Houde, Chanel
   Gaudreau, Genevieve
   Voisine, Pierre
TI Impact of deep sternal wound infection management with vacuum-assisted
   closure therapy followed by sternal osteosynthesis: a 15-year review of
   23 499 sternotomies
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Mediastinitis; VAC therapy; Sternal osteosynthesis
ID LONG-TERM SURVIVAL; POSTOPERATIVE MEDIASTINITIS; FIXATION;
   VASCULARIZATION; DEHISCENCE
AB Objective: This study was undertaken to examine the outcome of patients with deep sternal wound infection (DSWI) now treated with vacuum-assisted closure (VAC) therapy as a bridge to sternal osteosynthesis with horizontal titanium plate fixation. Methods: From 1992 to 2007, a consecutive cohort of 23 499 patients underwent open-heart surgery (OHS) in our institution. The period under study was divided in two according to the use of therapeutic modalities: conventional (1992-2001, N = 118 DSWI): debridement/drainage with primary closure and irrigation (N = 37), debridement/drainage, open packing followed by pectoralis myocutaneous flaps (PMFs) (N = 81); contemporary (2002-2007, N = 149 DSWI): conventional treatment (N = 24) and VAC therapy (N = 125/83.8%). VAC was followed by sternal osteosynthesis with horizontal titanium plates in 92 patients (61.7%). Results: DSWI was diagnosed in 267 out of 23 499 (1.1%) patients of our entire series according to Center for Disease Control Atlanta (CDC) criteria, 118 out of 13 180 (0.9%) in the first and 149 out of 10 319 (1.4%) in the second period (p = 0.001). Hospital mortality (N = 267/23 499) has been 10.25% for the entire cohort under study without any difference between groups (1992-2001: 11.4%; 2002 2007: 9.1%, p = 0.67). More recently, VAC therapy (N = 125) was associated with a lower mortality (4.8% vs 14.1%, p = 0.01). Stepwise multivariable logistic regression analysis for both periods revealed that prolonged intubation in the intensive care unit (ICU), use of bilateral internal thoracic artery grafting (BIMA), diabetes, re-operation for bleeding and body mass index (BMI) >30 kg m(2) are the most powerful predictors of DSWI. In the more recently treated patients using VAC therapy, combined procedures (valve and graft) also emerged as a significant predictor. For the entire study, Staphylococcus epidermidis (49.6%) has been the most frequently identified pathogen, followed by Staphylococcus aureus (38.8%). Methiciltin-resistant S. aureus (MRSA) was observed in 4.9% of the cohort. Neither of these bacteria was associated with increased mortality. Survival analysis with Cox regression model and propensity score adjustment in patients with DSWI showed freedom from all-cause mortality at 1, 5 and 10 years to be, respectively, 91.8%, 80.4% and 61.3% compared with 94.0%, 85.5% and 70.2%, respectively, for patients submitted to OHS without DSWI (p = 0.01). Early adjusted survival for patients with DSWI treated with VAC therapy was 92.8%, 89.8% and 88.0%, respectively, at 1, 2 and 3 years, compared with 83.0%, 76.4% and 61.3%, respectively, for patients with DSWI treated without VAC (p = 0.02). Conclusions: DSWI remains a major and challenging complication of OHS. VAC therapy with sternal preservation followed by delayed sternal osteosynthesis and PMF has been recently proposed as a new therapeutic strategy. Most patients treated with VAC therapy in our second group showed decreased perioperative mortality and increased short-term survival. (C) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
C1 [Baillot, Richard; Cloutier, Daniel; Montalin, Livia; Houde, Chanel; Gaudreau, Genevieve; Voisine, Pierre] Univ Laval, Dept Cardiac, Quebec City, PQ, Canada.
   [Baillot, Richard; Cloutier, Daniel; Montalin, Livia; Houde, Chanel; Gaudreau, Genevieve; Voisine, Pierre] Univ Laval, Dept Plast Surg, Quebec City, PQ, Canada.
   [Lellouche, Francois] Laval Hosp, Res Ctr, Quebec City, PQ, Canada.
   [Cote, Louise] Univ Laval, Dept Med Biol, Quebec City, PQ, Canada.
C3 Laval University; Laval University; Laval University
RP Baillot, R (通讯作者)，Hop Laval, Inst Univ Cardiol & Pneumol Quebec, 2725 Chemin Ste Foy, Quebec City, PQ G1V 4G5, Canada.
EM richard.baillot@chg.ulaval.ca
RI Lellouche, Francois/AAB-9014-2019
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NR 25
TC 125
Z9 141
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD APR
PY 2010
VL 37
IS 4
BP 880
EP 887
DI 10.1016/j.ejcts.2009.09.023
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 588DN
UT WOS:000277047700027
PM 19880326
OA Bronze
DA 2026-07-24
ER
PT J
AU Gaudreau, G
   Costache, V
   Houde, C
   Cloutier, D
   Montalin, L
   Voisine, P
   Baillot, R
AF Gaudreau, Genevieve
   Costache, Victor
   Houde, Chanel
   Cloutier, Daniel
   Montalin, Livia
   Voisine, Pierre
   Baillot, Richard
TI Recurrent sternal infection following treatment with negative pressure
   wound therapy and titanium transverse plate fixation
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 62nd Annual Meeting of the Canadian-Society-of-Plastic-Surgeons
CY JUN 24-28, 2008
CL St Johns, CANADA
SP Canadian Soc Plast Surg
DE Deep sternal wound infection; Mediastinitis; Negative pressure wound
   therapy; Sternal reconstruction with titanium plates
ID VACUUM-ASSISTED CLOSURE; OPEN-HEART-SURGERY; POSTSTERNOTOMY
   MEDIASTINITIS; POSTOPERATIVE MEDIASTINITIS; MUSCLE FLAPS; EXPERIENCE;
   MANAGEMENT; RECONSTRUCTION; DEHISCENCE; UNIT
AB Objective: To provide a definition for recurrent sternal infection (RSI), analyse the risk factors and describe the management of this complication following treatment of deep sternal wound infection (DSWI) with horizontal titanium sternal osteosynthesis and coverage with pectoralis major myocutaneous flaps. Methods: Between 2002 and 2007, 10 665 patients were submitted to open-heart surgery (OHS) in our institution, of whom 149 (1.4%) developed a DSWI. Negative pressure wound therapy (NPWT) followed by sternal osteosynthesis with musculocutaneous coverage was used in 92 (61.7%) patients. A retrospective review was done using a prospectively maintained database to identify risk factors for recurrent infection in this group of patients. Results: Of the 92 patients who underwent sternal osteosynthesis, nine (9.8%) developed recurrent sternal infection requiring hardware removal. Univariate analysis showed that preoperative methicillin-resistant Staphylococcus aureus (MRSA) status (33.3% vs 6.1%; p = 0.03) and prolonged intubation time in ICU (44.4% vs 14.6%; p < 0.05) were significant risk factors. Two-thirds of these patients were also found to be infected with the same germ as the one responsible for their initial DSWI. No death was reported and sternal integrity was preserved in all patients despite plate removal. Conclusions: To lower the rate of RSI in patients treated with transverse sternal ostheosynthesis along with myocutaneous coverage for DSWI, surgeons must consider the MRSA preoperative status as a significant predictor of RSI and /or persistent infection. Chest-wall integrity in patients with RSI can be maintained after hardware removal, even after only a few weeks following initial plating. (C) 2009 European Association for Cardio-Thoracic SurgeryElsevier B.V. All rights reserved.
C1 [Costache, Victor] CHU Grenoble, Serv Chirurg Cardiaque, Dept Cardiac Surg, F-38043 Grenoble, France.
   [Gaudreau, Genevieve; Houde, Chanel; Cloutier, Daniel; Montalin, Livia; Voisine, Pierre; Baillot, Richard] Univ Laval, Dept Cardiac & Plast Surg, Quebec City, PQ, Canada.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   CHU Grenoble Alpes; Laval University
RP Costache, V (通讯作者)，CHU Grenoble, Serv Chirurg Cardiaque, Dept Cardiac Surg, BP 217, F-38043 Grenoble, France.
EM victorscostache@gmail.com
RI Costache, Victor/AFC-8705-2022
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 25
TC 30
Z9 35
U1 0
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD APR
PY 2010
VL 37
IS 4
BP 888
EP 892
DI 10.1016/j.ejcts.2009.07.043
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 588DN
UT WOS:000277047700028
PM 19775906
DA 2026-07-24
ER
PT J
AU Dosluoglu, HH
   Loghmanee, C
   Lall, P
   Cherr, GS
   Harris, LM
   Dryjski, ML
AF Dosluoglu, Hasan H.
   Loghmanee, Cyrus
   Lall, Purandath
   Cherr, Gregory S.
   Harris, Linda M.
   Dryjski, Maciej L.
TI Management of early (&lt;30 day) vascular groin infections using
   vacuum-assisted closure alone without muscle flap coverage in a
   consecutive patient series
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 37th Annual Meeting of the Society-for-Clinical-Vascular-Surgery
CY MAR 18-21, 2009
CL Ft Lauderdale, FL
SP Soc Clin Vasc Surg
ID PROSTHETIC GRAFT INFECTIONS; NEGATIVE-PRESSURE; SYNTHETIC GRAFTS;
   THERAPY; PRESERVATION; EXPERIENCE; BYPASS; SARTORIUS; OUTCOMES; SURGERY
AB Objective: Vacuum-assisted closure (VAC) therapy without muscle flap coverage is our primary approach for graft preservation in early, deep groin infections with and without exposed grafts; however, concerns exist regarding its safety. We report our experience in a consecutive series of patients with early groin infections managed without muscle flap closure.
   Methods: All patients with early (<30 day), deep vascular groin infections without (Szilagyi II) or with (Szilagyi exposed vascular graft or suture line between January 2004 and December 2008 were reviewed. Graft preservation followed by local wound care with VAC was attempted in all with intact anastomoses, patent grafts, and absence of systemic sepsis. Szilagyi classification, microorganism cultured, duration of VAC use, time to healing, additional interventions, and follow-up data (limb salvage, survival) were analyzed.
   Results: Twenty-two patients (26 groins, mean age 69.1 +/- 9.5 years [range, 44-86 years]) presented with deep groin infections 16 +/- 5 days (range, 7-28 days) after the index procedure (bypass-polytetrafluoroethylene [n = 11], autologous vein [n = 3], endarterectomy/patch [n = 6], extra-anatomic bypass [n = 5], percutaneous closure device [n = 1]). Grafts were exposed in 12 groins (Szilagyi III, nine with suture lines). VAC was started one to six days (median, three) after operative debridement. All had positive wound cultures and received culture-directed antibiotic therapy for 47 45 days (range, 14-180 days). Length of stay was significantly more in Szilaui III, whereas mean VAC use and time-to-healing were similar. Mean follow-up was 33.4 +/- 19.5 months (range, 2-72 months). All wounds healed (mean, 49 +/- 21 days). Two treatment failures occurred in the Szilagyi III group (17%). One patient had bleeding from the anastomotic heel eight days after debridement, had graft removal/in situ replacement and one presented with reinfection on day 117 and had partial graft removal/extra-anatomic bypass. There was no perioperative mortality or limb loss, but six late unrelated mortalities and one amputation at 46 months unrelated to the groin infection.
   Conclusions:Management of early, deep groin wound infections with debridement, antibiotics, and VAC treatment is safe and enables graft preservation in the majority of patients with minimal morbidity, no perioperative limb loss, or mortality. (J Vase Surg 2010;51:1160-6.)
C1 [Dosluoglu, Hasan H.; Lall, Purandath] Vet Affairs Med Ctr, Div Vasc Surg, Minnepolis, MN USA.
   [Dosluoglu, Hasan H.; Loghmanee, Cyrus; Cherr, Gregory S.; Harris, Linda M.; Dryjski, Maciej L.] SUNY Buffalo, Div Vasc Surg, Dept Surg, Buffalo, NY 14260 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   State University of New York (SUNY) System; University at Buffalo, SUNY
RP Dosluoglu, HH (通讯作者)，VA Western NY Healthcare Syst, 3495 Bailey Ave, Buffalo, NY 14215 USA.
EM dosluoglu@yahoo.com
RI Harris, Linda/HGD-5419-2022
CR Abai B, 2007, J VASC SURG, V45, P610, DOI 10.1016/j.jvs.2006.10.043
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   Seify H, 2006, PLAST RECONSTR SURG, V117, P1325, DOI 10.1097/01.prs.0000204961.32022.ab
   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
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NR 31
TC 86
Z9 98
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD MAY
PY 2010
VL 51
IS 5
BP 1160
EP 1166
DI 10.1016/j.jvs.2009.11.053
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA 590HL
UT WOS:000277216000013
PM 20356703
OA Bronze
DA 2026-07-24
ER
PT J
AU Perathoner, A
   Klaus, A
   Mühlmann, G
   Oberwalder, M
   Margreiter, R
   Kafka-Ritsch, R
AF Perathoner, Alexander
   Klaus, Alexander
   Muehlmann, Gilbert
   Oberwalder, Michael
   Margreiter, Raimund
   Kafka-Ritsch, Reinhold
TI Damage control with abdominal vacuum therapy (VAC) to manage perforated
   diverticulitis with advanced generalized peritonitis-a proof of concept
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Diverticulitis; VAC; Peritonitis; Colostomy
ID SIGMOID DIVERTICULITIS; HARTMANNS PROCEDURE; EMERGENCY-SURGERY; PRIMARY
   RESECTION; OPEN ABDOMEN; ANASTOMOSIS; CLOSURE; DISEASE; STRATEGIES;
   DIAGNOSIS
AB Perforated diverticulitis with advanced generalized peritonitis is a life-threatening condition requiring emergency operation. To reduce the rate of colostomy formation, a new treatment algorithm with damage control operation, lavage, limited closure of perforation, abdominal vacuum-assisted closure (VAC; V.A.C.A (R)), and second look to restore intestinal continuity was developed.
   This algorithm allowed for three surgical procedures: primary anastomosis +/- VAC in stable patients (group I), but damage control with lavage, limited resection of the diseased colonic segment, VAC and second-look operation with delayed anastomosis in patients with advanced peritonitis or septic shock (group II), and Hartmann procedure was done for social reasons in stable patients (group III)
   All 27 consecutive patients (16 women; median age 68 years) requiring emergency laparotomy for perforated diverticulitis (Hinchey III/IV) between October 2006 and September 2008 were prospectively enrolled in the study. No major complications were observed in group I (n = 6). Nine patients in group II (n = 15) had intestinal continuity restored during a second-look operation, of whom one patient developed anastomotic leakage. The median length of stay at intensive care unit was 5 days. Considering an overall mortality rate of 26% (n = 7), the rate of anastomosis in surviving patients was 70%.
   Damage control with lavage, limited bowel resection, VAC, and scheduled second-look operation represents a feasible strategy in patients with perforated diverticulitis (Hinchey III and IV) to enhance sepsis control and improve rate of anastomosis.
C1 [Perathoner, Alexander; Klaus, Alexander; Muehlmann, Gilbert; Oberwalder, Michael; Margreiter, Raimund; Kafka-Ritsch, Reinhold] Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck
RP Kafka-Ritsch, R (通讯作者)，Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, Anichstr 35, A-6020 Innsbruck, Austria.
EM reinhold.kafka-ritsch@uki.at
CR Ansari MZ, 2000, AUST NZ J SURG, V70, P6, DOI 10.1046/j.1440-1622.2000.01733.x
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NR 30
TC 66
Z9 70
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-1958
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD JUN
PY 2010
VL 25
IS 6
BP 767
EP 774
DI 10.1007/s00384-010-0887-8
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 590QM
UT WOS:000277242100013
PM 20148255
DA 2026-07-24
ER
PT J
AU DeCarbo, WT
   Hyer, CF
AF DeCarbo, William T.
   Hyer, Christopher F.
TI Negative-pressure Wound Therapy Applied to High-risk Surgical Incisions
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE calcaneus; fracture; healing; surgery; total ankle replacement; vacuum
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; TRAUMA
AB Negative-pressure wound therapy (NPWT) is commonly used for chronic wounds, open fractures with soft tissue defects, and coverage over split-thickness skin grafts. NPWT uniformly draws wounds closed by helping to remove interstitial fluid, which contains inflammatory and potentially infectious exudate that could impair healing. Recently in our practice, we have used NPWT in cases involving tenuous incisions, such as those used to access target structures during total ankle replacement or open repair of joint depression calcaneal fractures, in an effort to prevent hematoma or wound dehiscence. Although it is generally understood that NPWT can be efficacious and cost-effective for management of a wide range of lower extremity wounds, we also believe it to be beneficial in the management of low-energy trauma and elective hindfoot and ankle reconstructions, and feel that it has led to decreased pain, swelling, and time to healing in our patients. Based on our experience with ankle arthroplasty and the surgical management of hindfoot and ankle trauma, we believe that the use of NWPT in the immediate postoperative period is both safe and efficacious. (C) 2010 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [DeCarbo, William T.; Hyer, Christopher F.] Orthoped Foot & Ankle Ctr, Westerville, OH 43082 USA.
RP DeCarbo, WT (通讯作者)，Orthoped Foot & Ankle Ctr, 300 Polaris Pkwy,Suite 2000, Westerville, OH 43082 USA.
EM ofacresearch@orthofootankle.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Flack S, 2008, J Wound Care, V17, P71
   Herscovici D, 2003, J ORTHOP TRAUMA, V17, P683, DOI 10.1097/00005131-200311000-00004
   Hunter Judith E, 2007, Int Wound J, V4, P256, DOI 10.1111/j.1742-481X.2007.00361.x
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Weinberg Group Inc, 1999, TECHN ASS V A C IN H, P61
NR 8
TC 47
Z9 56
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAY-JUN
PY 2010
VL 49
IS 3
BP 299
EP 300
DI 10.1053/j.jfas.2010.01.002
PG 2
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 593RZ
UT WOS:000277479500013
PM 20605565
DA 2026-07-24
ER
PT J
AU Rispoli, DM
   Horne, BR
   Kryzak, TJ
   Richardson, MW
AF Rispoli, Damian M.
   Horne, Brandon R.
   Kryzak, Thomas J.
   Richardson, Mark W.
TI Description of a Technique for Vacuum-Assisted Deep Drains in the
   Management of Cavitary Defects and Deep Infections in Devastating
   Military and Civilian Trauma
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Vacuum-assisted closure; Negative-pressure wound therapy; War; Cavitary;
   Infection
ID PRESSURE WOUND THERAPY; CLOSURE THERAPY; EXPERIENCE; DEVICE; FLUID
AB Background: Deep soft-tissue defects often present in high-energy trauma and during the surgical treatment of infection. Injuries caused by high-velocity projectiles can create deep soft-tissue defects that are challenging to manage. Persistent, deep wound cavities have been associated with infection and prolonged wound healing. This article presents a technique that marries vacuum-assisted wound closure technology with traditional drains to allow for management of deep soft-tissue cavities.
   Methods: A deep drain was placed in the cavitary lesion with application of a negative-pressure wound therapy sponge in the standard fashion. The deep drain was brought into the sponge and fenestrated as to allow the sponge to evacuate the deep drain. Several illustrative cases are presented.
   Results: Conversion of deep cavitary defects to superficial defects allowed for delayed primary or secondary closure of the wound defects without the need for increasing the size of the superficial wound to facilitate drainage. Deep infection was also successfully controlled without incurring the additional surgical soft-tissue trauma typical of standard technique.
   Conclusions: The use of the active deep suction decreases edema and dead space, theoretically reducing the chance of infection. It also prevents premature walling off of deeper cavities, which can occur with the use of vacuum-assisted closure therapy on superficial defects. Our method of wound management allows for the reduction of the deep cavitary defects without delaying wound closure or creating more tissue damage.
C1 [Rispoli, Damian M.; Kryzak, Thomas J.] San Antonio Mil Med Ctr Wilford Hall Med Ctr, Dept Orthopaed, Lackland AFB, TX USA.
   [Horne, Brandon R.] Wright Patterson Med Ctr, Wright Patterson AFB, OH USA.
   [Richardson, Mark W.] Wellspan Hlth, Dept Orthopaed, York, PA USA.
C3 Brooke Army Medical Center
RP Rispoli, DM (通讯作者)，59MDW SGO40,2200 Bergquist Dr,Suite 1, Lackland AFB, TX 78326 USA.
EM damian.rispoli@lackland.af.mil
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NR 31
TC 29
Z9 31
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD MAY
PY 2010
VL 68
IS 5
BP 1247
EP 1252
DI 10.1097/TA.0b013e3181d3cc3c
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 595MQ
UT WOS:000277615200034
PM 20453774
DA 2026-07-24
ER
PT J
AU Brox-Jiménez, A
   Díaz-Gómez, D
   Parra-Membrives, P
   Martínez-Baena, D
   Márquez-Muñoz, M
   Lorente-Herce, J
   Jiménez-Vega, J
AF Brox-Jimenez, Antonia
   Diaz-Gomez, Daniel
   Parra-Membrives, Pablo
   Martinez-Baena, Dario
   Marquez-Munoz, Macarena
   Lorente-Herce, Jose
   Jimenez-Vega, Javier
TI A vacuum assisted closure system in complex wounds: a retrospective
   study
SO CIRUGIA ESPANOLA
LA Spanish
DT Article
DE Vacuum-assisted closure (VAC therapy); Complex wounds; Therapy
ID OPEN ABDOMEN; THERAPY
AB Introduction: Vacuum-assisted closure (VAC) therapy is a dynamic and non-invasive system for improving wound healing. This novel therapy is based on applying air suction at a controlled sub-atmospheric pressure. The most important benefits of this therapy include, a reduction in the wound area together with induction of new granulation tissue formation, effective wound cleansing (removal of small tissue by suction), and the continuous removal of wound exudate.
   The aim of this study was to describe our experience with VAC therapy for complex wounds.
   Material and method: We retrospectively evaluated our experience with VAC therapy between April 2007 and August 2008. We employed a "suprafascial" VAC system and an open abdomen VAC system. Descriptive statistical techniques were applied and percentages and means were calculated.
   Results: VAC therapy was applied in 20 patients, of whom 16(80%) had abdominal complex wounds, and 4(20%) in other locations. We employed a "suprafascial" VAC system in 17 patients (85%) and an "intra-abdominal" VAC system in 3 patients (15%). Two patients (10%) developed fistula during "intra-abdominal" VAC therapy (urinary and enteric) but the closure was achieved before therapy was finished. Mean hospital stay was 38.3 days (7-136). No mortality was directly due to the VAC system. Two patients (10%) died due to their septic condition and the rest are still alive. Mean therapy length was 29.17 days (1-77) in the "suprafascial" group and 18 days (7-49) in the "intra-abdominal" group. Average costs were 3197.97 (sic) (119.1-10780.25) per patient.
   Conclusions: VAC therapy can improve and accelerate abdominal wound healing also in the presence of infection and bowel fistula. (C) 2009 AEC. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Brox-Jimenez, Antonia] Complejo Hosp Pontevedra, Serv Cirugia Gen & Aparato Digest, Pontevedra, Spain.
   [Diaz-Gomez, Daniel; Parra-Membrives, Pablo; Martinez-Baena, Dario; Marquez-Munoz, Macarena; Lorente-Herce, Jose; Jimenez-Vega, Javier] Hosp Univ Valme, Serv Cirugia Gen & Aparato Digest, Seville, Spain.
C3 Complexo Hospitalario Universitario de Pontevedra; Hospital Valme
RP Brox-Jiménez, A (通讯作者)，Complejo Hosp Pontevedra, Serv Cirugia Gen & Aparato Digest, Pontevedra, Spain.
EM broxji@yahoo.es
RI ; Parra Membrives, Pablo/A-8851-2019; Martínez-Baena,
   Darío/HHC-3406-2022
OI Lorente-Herce, José Manuel/0000-0002-0579-6306; Parra Membrives,
   Pablo/0000-0002-5044-4828; 
CR Arigon JP, 2008, J CHIR-PARIS, V145, P252, DOI 10.1016/S0021-7697(08)73755-4
   Brox-Jimenez Antonia, 2007, Cir Esp, V82, P150
   de Costa A, 2006, ANZ J SURG, V76, P356, DOI 10.1111/j.1445-2197.2006.03638.x
   Heller L, 2006, AM J SURG, V191, P165, DOI 10.1016/j.amjsurg.2005.09.003
   MUNOZ A, 2007, VAC THERAPY APLICACI
   Olejnik J, 2007, BRATISL MED J, V108, P320
   Robledo-Ogazon Felipe, 2006, Cir Cir, V74, P107
   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
   Wild T, 2007, Ther Umsch, V64, P495, DOI 10.1024/0040-5930.64.9.495
NR 9
TC 13
Z9 22
U1 0
U2 10
PU ELSEVIER DOYMA SL
PI BARCELONA
PA TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD MAY
PY 2010
VL 87
IS 5
BP 312
EP 317
DI 10.1016/j.ciresp.2010.02.001
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 596FC
UT WOS:000277669300008
PM 20378103
DA 2026-07-24
ER
PT J
AU Borgquist, O
   Gustafsson, L
   Ingemansson, R
   Malmsjö, M
AF Borgquist, Ola
   Gustafsson, Lotta
   Ingemansson, Richard
   Malmsjo, Malin
TI Micro- and Macromechanical Effects on the Wound Bed of Negative Pressure
   Wound Therapy Using Gauze and Foam
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE animal model; experimental surgery; negative pressure wound therapy;
   wound healing; wound contraction; macrodeformation; microdeformation
ID VACUUM-ASSISTED CLOSURE; CELL-SHAPE
AB Negative pressure wound therapy (NPWT) results in 2 types of tissue deformation, macrodeformation (ie, wound contraction) and microdeformation (ie, the interaction of tissue and dressing on a microscopic level). These effects have been delineated for one type of wound filler, foam, but not for gauze. The mechanical deformation initiates a signaling cascade which ultimately leads to wound healing. The aim of the present study was to examine the effect of gauze and foam on macro-and microdeformation during treatment with negative pressure.
   An in vivo porcine peripheral wound model was used. NPWT was applied for 72 hours at 0, -75, and -125 mm Hg, using either foam or gauze as wound filler. The mechanical effects of NPWT were examined by measuring the wound surface area reduction and by histologic analysis of the wound bed tissue.
   Similar degrees of wound contraction (macrodeformation) were seen during NPWT regardless if foam or gauze was used. After negative pressure had been discontinued, the wound stayed contracted. There was no difference in wound contraction between -75 and -125 mm Hg. Biopsies of the wound bed revealed a repeating pattern of wound surface undulations and small tissue blebs ("tissue mushrooms") were pulled into the pores of the foam dressing and the spaces between the threads in the gauze dressing (microdeformation). This pattern was obvious in wounds treated both with foam and gauze, at atmospheric pressure (0 mm Hg) as well as at subatmospheric pressures (-75 and -125 mm Hg).
   The degrees of micro-and macrodeformation of the wound bed are similar after NPWT regardless if foam or gauze is used as wound filler.
C1 [Borgquist, Ola; Gustafsson, Lotta; Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden.
   [Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@gmail.com
RI ; Borgquist, Ola/AAO-6451-2020
OI Ingemansson, Richard/0000-0001-7623-8953; Gustafsson,
   Lotta/0000-0002-9826-9133; Maljö, Malin/0000-0001-9849-9599; 
FU Ake-Wieberg Foundation; Magn. Bergvall Foundation; Swedish Medical
   Association; Royal Physiographic Society in Lund; Swedish Medical
   Research Council; Crafoord Foundation; Swedish Heart-Lung Foundation;
   Swedish Government; Swedish Hypertension Society; Prospera
FX Supported by the Ake-Wieberg Foundation, the Magn. Bergvall Foundation,
   the Swedish Medical Association, the Royal Physiographic Society in
   Lund, the Swedish Medical Research Council, the Crafoord Foundation, the
   Swedish Heart-Lung Foundation, the Swedish Government Grant for Clinical
   Research, the Swedish Hypertension Society, and Prospera.
CR AUSTAD ED, 1986, PLAST RECONSTR SURG, V78, P63, DOI 10.1097/00006534-198607000-00009
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NR 20
TC 87
Z9 103
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2010
VL 64
IS 6
BP 789
EP 793
DI 10.1097/SAP.0b013e3181ba578a
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 602CU
UT WOS:000278116900021
PM 20489409
DA 2026-07-24
ER
PT J
AU McNulty, A
   Spranger, I
   Courage, J
   Green, J
   Wilkes, R
   Rycerz, A
AF McNulty, Amy
   Spranger, Ian
   Courage, James
   Green, Jeff
   Wilkes, Robert
   Rycerz, Anthony
TI The Consistent Delivery of Negative Pressure to Wounds Using
   Reticulated, Open Cell Foam and Regulated Pressure Feedback
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID FIBRIN MATRIX; THERAPY; TENSION; GROWTH; PROLIFERATION; GENESIS; TISSUES
AB Negative pressure wound therapy (NPWT) is used to manage wounds and promote wound healing. The most common form of NPWT utilizes reticulated, open cell foam (ROCF). Pressure is transferred to the wound by ROCF using T.R.A.C.(TM) Technology (regulated pressure feedback [RPF]) creating an environment that promotes healing. This study examines the effectiveness of ROCF versus gauze in inducing macrostrain and investigates the ability of NPWT/ROCF/RPF to consistently deliver negative pressure to the wound, compensating for constantly changing wound fluid characteristics. In an in-vitro model, ROCF induced significantly greater macrostrain than gauze demonstrating a 57% decrease in dressing surface area following negative pressure application. The decrease measured with gauze under suction (GUS) was insignificant. The NPWT/ROCF/RPF system consistently delivered negative pressure to the wound when compared to GUS or ROCF without RPF. Further, with the negative pressure source elevated 36 in (90 cm) above surrogate wounds, GUS demonstrated a 7- to 10-fold pressure drop when compared to NPWT/ROCF/RPF. Systems without RPF are limited because they cannot sense or measure pressure delivered at the wound. In situations where pressure drop occurs, neither the clinician nor patient would necessarily know that suboptimal pressure was being delivered to the wound. Therefore, a system with ROOF and RPF capability that effectively monitors and maintains the NPWT environment plays a crucial role in the optimal induction of macrostrain and microstrain. The ability of the NPWT/ROCF/RPF system to monitor and maintain controlled, consistent delivery of negative pressure would seem important to achieve desired clinical outcomes.
C1 [McNulty, Amy; Spranger, Ian; Courage, James; Green, Jeff; Wilkes, Robert; Rycerz, Anthony] Kinet Concepts Inc, San Antonio, TX USA.
RP McNulty, A (通讯作者)，Kinet Concepts Inc, 8023 Vantage Dr, San Antonio, TX USA.
EM amy.mcnulty@kci1.com
CR Abbott CA, 2002, DIABETIC MED, V19, P377, DOI 10.1046/j.1464-5491.2002.00698.x
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NR 24
TC 14
Z9 16
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2010
VL 22
IS 5
BP 114
EP 120
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 603JL
UT WOS:000278204800002
PM 25902176
DA 2026-07-24
ER
PT J
AU Bollero, D
   Driver, V
   Glat, P
   Gupta, S
   Lázaro-Martinez, JL
   Lyder, C
   Ottonello, M
   Pelham, F
   Vig, S
   Woo, K
AF Bollero, Daniele
   Driver, Vickie
   Glat, Paul
   Gupta, Subhas
   Lazaro-Martinez, Jose Luis
   Lyder, Courtney
   Ottonello, Manlio
   Pelham, Francis
   Vig, Stella
   Woo, Kevin
TI The Role of Negative Pressure Wound Therapy in the Spectrum of Wound
   Healing
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE negative pressure wound therapy; moist wound healing; traumatic and
   surgical wounds; pressure ulcers; diabetic foot ulcers; venous ulcers
   and arterial ulcers
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; RANDOMIZED
   CONTROLLED-TRIAL; PARTIAL-THICKNESS BURNS; CHRONIC LEG ULCERS;
   SUBATMOSPHERIC PRESSURE; OCCLUSIVE DRESSINGS; ALGINATE DRESSINGS;
   SUPERFICIAL WOUNDS; IONIC SILVER
AB Wound care clinicians have a wide array of available treatment options to manage and help heal acute and chronic complex wounds that require a systematized and comprehensive approach to address the complexity of wound care and to optimize patient outcomes. The treatment of wounds represents a major cost to society. Public policies increasingly focus on quality of care, patient outcomes, and lowering costs. Wound care clinicians are not immune to these pressures. Wound care clinicians must ensure that their assessments, treatment pathways, and product selections are both clinically and economically sound.
   Negative pressure wound therapy (NPWT) has been demonstrated to be an efficacious option to promote healing in a variety of acute and chronic complex wounds. Previous guidelines on the use of NPWT have focused on application but have not provided recommendations on when it is most appropriate to use NPWT; there are few criteria for 1) when to initiate NPWT based on various wound types, 2) pre-application management to optimize treatment outcomes, 3) identification of appropriate candidates for NPWT, 4) benchmark indicators for treatment response, and 5) recommendations on when to transition between NPWT and moist wound healing (MWH) or another treatment mooality.
   In September 2009, an international panel of wound care experts from multiple disciplines convened to develop a document to guide clinicians in making decisions about the appropriate use of NPWT within the spectrum of wound healing. Where empirical research was lacking, clinical experiences and patient factors were considered to ensure the clinical utility of the document. The goal of these guidelines is to encourage responsible wound management across the healthcare continuum and spectrum of wound pathologies to achieve positive, cost-effective patient outcomes.
C1 [Bollero, Daniele] CTO Hosp Torino, Dept Plast Surg Burn Unit, Turin, Italy.
   [Driver, Vickie] Boston Univ, Boston Med Ctr, Boston, MA USA.
   [Glat, Paul] St Christophers Hosp Children, Philadelphia, PA USA.
   [Gupta, Subhas] Loma Linda Univ, Med Ctr, Dept Plast Surg, Loma Linda, CA 92354 USA.
   [Lazaro-Martinez, Jose Luis] Univ Complutense Madrid, Diabet Foot Unit, Madrid, Spain.
   [Lyder, Courtney] Ronald Reagan UCLA Med Ctr, Sch Nursing, Los Angeles, CA USA.
   [Ottonello, Manlio] S Corona Hosp, Spinal Cord Unit, Pietra Ligure, Italy.
   [Pelham, Francis] NYU, Sch Med, Langone Med Ctr, Hosp Joint Dis, New York, NY USA.
   [Vig, Stella] Mayday Univ Hosp, Croydon, England.
   [Woo, Kevin] Univ Toronto, Fac Nursing, Toronto, ON, Canada.
C3 A.O.U. Citta della Salute e della Scienza di Torino; Boston Medical
   Center; Boston University; Loma Linda University; Complutense University
   of Madrid; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; Ronald
   Reagan UCLA Medical Center; NYU Langone Medical Center; Hospital for
   Joint Disease NYULMC; New York University; Croydon University Hospital;
   University of Toronto
RP Gupta, S (通讯作者)，Loma Linda Univ, Med Ctr, Dept Plast Surg, Loma Linda, CA 92354 USA.
EM sgupta@ahs.llumac.edu
RI ; Gupta, Subhas/C-5458-2018; MARTINEZ, JOSE/AAE-2268-2021
OI Chhabda, Tejinder/0000-0003-3155-3129; 
CR *AG HEALTHC RES QU, NEG PRESS WOUND THER
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   *NAT PRESS ULC ADV, PRESS ULC TREATM QUI
   *NAT PRESS ULC ADV, PRESS ULC STAG REV N
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NR 76
TC 19
Z9 22
U1 0
U2 19
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAY
PY 2010
SU S
BP 4
EP +
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 604GM
UT WOS:000278267500001
DA 2026-07-24
ER
PT J
AU Nather, A
   Chionh, SB
   Han, AYY
   Chan, PPL
   Nambiar, A
AF Nather, Aziz
   Chionh, Siok Bee
   Han, Audrey Y. Y.
   Chan, Pauline P. L.
   Nambiar, Ajay
TI Effectiveness of Vacuum-assisted Closure (VAC) Therapy in the Healing of
   Chronic Diabetic Foot Ulcers
SO ANNALS ACADEMY OF MEDICINE SINGAPORE
LA English
DT Article
DE Diabetic foot wound; Negative pressure dressing; Wound healing
ID WOUNDS
AB Introduction: This is the first prospective study done locally to determine the effectiveness of vacuum-assisted closure (VAC) therapy in the healing of chronic diabetic foot ulcers. Materials and Methods: An electronic vacuum pump was used to apply controlled negative pressure evenly across the wound surface. Changes in wound dimension, presence of wound granulation and infection status of diabetic foot ulcers in 11 consecutive patients with diabetes were followed over the course of VAC therapy. Results: Healing was achieved in all wounds. Nine wounds were closed by split-skin grafting and 2 by secondary closure. The average length of treatment with VAC therapy was 23.3 days. Ten wounds showed reduction in wound size. All wounds were satisfactorily granulated and cleared of bacterial infection at the end of VAC therapy. Conclusions: VAC therapy was useful in the treatment of diabetic foot infection and ulcers, which after debridement, may present with exposed tendon, fascia and/or bone. These included ray amputation wounds, wounds post-debridement for necrotising fasciitis, wounds post-drainage for abscess, a heel ulcer and a sole ulcer. It was able to prepare ulcers well for closure via split-skin grafting or secondary closure in good time. This reduced cost of VAC therapy, as therapy was not prolonged to attain greater reduction in wound area. VAC therapy also provides a sterile, more controlled resting environment to large, exudating wound surfaces. Large diabetic foot ulcers were thus made more manageable. Ann Acad Med Singapore 2010;39:353-8
C1 [Nather, Aziz; Han, Audrey Y. Y.; Chan, Pauline P. L.; Nambiar, Ajay] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Orthopaed Surg, Singapore 119074, Singapore.
   [Chionh, Siok Bee] Natl Univ Hlth Syst, Dept Med, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore
RP Nather, A (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Orthopaed Surg, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore.
EM dosnathe@nus.edu.sg
CR Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Banwell P E, 1999, J Wound Care, V8, P79
   Banwell P E, 2003, J Wound Care, V12, P22
   Brem H, 2006, PLAST RECONSTR SURG, V117, p193S, DOI 10.1097/01.prs.0000225459.93750.29
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   ERASMUS A, 2008, DIABETIC FOOT PROBLE
   Lavery Lawrence A, 2007, Int Wound J, V4, P103, DOI 10.1111/j.1742-481X.2007.00317.x
   *MIN HLTH SING EP, 2004, NAT HLTH SURV 2004
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   NATHER A, 2007, J ORTHOP SURG, V15, P230
   Nather A., 2008, DIABETIC FOOT PROBLE
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
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NR 17
TC 47
Z9 58
U1 2
U2 21
PU ACAD MEDICINE SINGAPORE
PI REPUBLIC SINGAPORE
PA 142 NEIL RD, REPUBLIC SINGAPORE 088871, SINGAPORE
SN 0304-4602
J9 ANN ACAD MED SINGAP
JI Ann. Acad. Med. Singap.
PD MAY
PY 2010
VL 39
IS 5
BP 353
EP 358
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 606OF
UT WOS:000278435400003
PM 20535423
DA 2026-07-24
ER
PT J
AU Schintler, MV
   Grohmann, M
   Donia, C
   Aberer, E
   Scharnagl, E
AF Schintler, Michael V.
   Grohmann, Martin
   Donia, Claudio
   Aberer, Elisabeth
   Scharnagl, Erwin
TI Management of an unfortunate triad after breast reconstruction: Pyoderma
   gangrenosum, full-thickness chest wall defect and Acinetobacter
   Baumannii Infection
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article; Proceedings Paper
CT 1st International Workshop on Wound Technology
CY JAN 18-19, 2009
CL Paris, FRANCE
DE Breast reconstruction; Post-surgical pyoderma gangrenosum; Chest wall
   infection; MDR; Acinetobacter baumannii; VAC Instill (R)
AB If diagnosed late, post-surgical pyoderma gangrenosum (PSPG) is a rare, tricky and potentially life-threatening complication. Once diagnosed, immunosuppressive agents may provoke further complications. Well-intentioned extensive serial debridement may cause deep skin and soft-tissue defects, requiring skin grafting and possible flap surgery. The combination of necessary immunosuppressive treatment, protracted hospital stay and broad-spectrum systemic antimicrobial therapy may encourage serious acquired multidrug resistance (MDR). We report an unfortunate triad following breast reconstruction of PSPG, full-thickness chest wall defect and MDR with Acinetobacter baumannii infection. Interdisciplinary treatment using free flap surgery and negative-pressure wound therapy with instillation therapy (V.A.C.Instill (R) Wound Therapy) enabled survival and complete wound closure. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Schintler, Michael V.; Grohmann, Martin; Donia, Claudio; Scharnagl, Erwin] Med Univ Graz, Dept Surg, Div Plast Surg, A-8036 Graz, Austria.
   [Donia, Claudio] Univ Catania, Cannizzaro Hosp, Div Plast Surg, I-95126 Catania, Italy.
   [Aberer, Elisabeth] Med Univ Graz, Dept Dermatol, A-8036 Graz, Austria.
C3 Medical University of Graz; University of Catania; Medical University of
   Graz
RP Schintler, MV (通讯作者)，Med Univ Graz, Dept Surg, Div Plast Surg, Auenbruggerpl 29, A-8036 Graz, Austria.
EM michael.schintler@meduni-graz.at
CR Brocq L., 1916, ANN DERMATOL SYPHIL, V9, P1
   Brunsting LA, 1930, ARCH DERMATOL SYPH, V22, P655, DOI 10.1001/archderm.1930.01440160053009
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   Jain A, 2000, BRIT J PLAST SURG, V53, P437, DOI 10.1054/bjps.2000.3351
   LONG CC, 1992, BRIT J DERMATOL, V127, P45, DOI 10.1111/j.1365-2133.1992.tb14826.x
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   Weenig RH, 2002, NEW ENGL J MED, V347, P1412, DOI 10.1056/NEJMoa013383
NR 10
TC 36
Z9 37
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JUL
PY 2010
VL 63
IS 7
BP E564
EP E567
DI 10.1016/j.bjps.2009.12.013
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 609KV
UT WOS:000278656200028
PM 20153277
DA 2026-07-24
ER
PT J
AU Le Franc, B
   Sellal, O
   Grimandi, G
   Duteille, F
AF Le Franc, B.
   Sellal, O.
   Grimandi, G.
   Duteille, F.
TI Cost-effectiveness analysis of vacuum-assisted closure in the surgical
   wound bed preparation of soft tissue injuries
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Vacuum-assisted closure; Cost-effectiveness; Reconstructive surgery;
   Soft tissue injuries; Open fracture
ID MANAGEMENT
AB This work proposes, from the point of view of the University Hospital Center of Nantes (acute care), a cost-effectiveness assessment of negative pressure wound therapy (NPWT), in comparison with moist wound therapy, in the surgical preparation of cutaneous defects requiring reconstructive surgery. This retrospective study was realized after data collection from patient files with hospitalization for the management of open-leg fractures with a view to reconstructive surgery by graft or flap (Cauchoix II or III). Effectiveness criteria, after debridement and NWPT initiation, was the time period required for preparing the wound for definitive reconstructive surgery closure by flap or graft. NWPT is compared, over the same 2000 to 2006 period, to the only existing therapeutic alternative, that is to say moist wound therapy. Only direct costs in relation with consumed resources dedicated to each medical strategy were taken into account. A Mann-Whitney U nonparametric test and boostrap technique have been used for statistical and sensitivity analysis. Twenty-five patients were recruited for the two medical strategies. Wound preparation time is significantly shorter for patient treated with NPWT (p = 0.026 Mann-Whitney U-test) and is equal to 20 days less on average for time period required for preparing the wound for reconstructive surgery. Hospitalization costs is very significantly lower for patients being treated with NPWT (p = 0.02). In absolute value, this cost is reduced on the average by 6000 (sic) per patient (i.e. by more than 60%). The incremental cost-effectiveness ratio is of the order of 164 (sic) per day of wound preparation for surgery gained. (C) 2009 Elsevier Masson SAS. All rights reserved.
C1 [Le Franc, B.; Sellal, O.; Grimandi, G.] CHU Nantes, Hop St Jacques, F-44000 Nantes, France.
   [Duteille, F.] CHU Nantes, Hotel Dieu, Serv Chirurg Plast, F-44000 Nantes, France.
C3 Nantes Universite; CHU de Nantes; Nantes Universite; CHU de Nantes
RP Le Franc, B (通讯作者)，CHU Nantes, Hop St Jacques, 85 Rue St Jacques Arsenal, F-44000 Nantes, France.
EM arz7614@yahoo.fr
RI /A-5380-2015
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Bihariesingh VJ, 2004, ARCH ORTHOP TRAUM SU, V124, P73, DOI 10.1007/s00402-003-0615-8
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   Herscovici D, 2003, J ORTHOP TRAUMA, V17, P683, DOI 10.1097/00005131-200311000-00004
   Launois R, 2003, B CANCER, V90, P946
   Launois R., 1999, J EC MED, V17, P77
   Moues C M, 2005, J Wound Care, V14, P224
   Revol M, 1993, Manuel de chirurgie plastique, reconstructrice et esthetique, P350
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   WORONOFFLEMSI MC, 2000, DOSSIER CNHIM, V21, P40
   RESUME RECOMMANDATIO
   PRESENTATION TABLES
NR 16
TC 9
Z9 14
U1 0
U2 4
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
EI 1768-319X
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD JUN
PY 2010
VL 55
IS 3
BP 195
EP 203
DI 10.1016/j.anplas.2009.04.001
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 609MR
UT WOS:000278661300004
PM 19640626
DA 2026-07-24
ER
PT J
AU Marinis, A
   Gkiokas, G
   Anastasopoulos, G
   Fragulidis, G
   Theodosopoulos, T
   Kotsis, T
   Mastorakos, D
   Polymeneas, G
   Voros, D
AF Marinis, Athanasios
   Gkiokas, Georgios
   Anastasopoulos, Georgios
   Fragulidis, Georgios
   Theodosopoulos, Theodosios
   Kotsis, Thomas
   Mastorakos, Dimitrios
   Polymeneas, George
   Voros, Dionisios
TI Surgical Techniques for the Management of Enteroatmospheric Fistulae
SO SURGICAL INFECTIONS
LA English
DT Article; Proceedings Paper
CT 21st Annual Congress of the Surgical-Infection-Society-Europe
CY MAY 01-03, 2008
CL Antalya, TURKEY
SP Surg Infect Soc Europe
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM PACK TECHNIQUE; OPEN ABDOMEN;
   EXPERIENCE; TRAUMA
AB Background: An intestinal fistula in the "open abdomen" is called "enteroatmospheric" and is a great challenge for the surgeon because of the high mortality and morbidity rates associated with it. This report is a study of the surgical strategy for treating patients with enteroatmospheric fistulae.
   Methods: During a 3-year period (2005-2007), two males and one female patient with a mean age of 63 years were referred to our surgical department for management of enteroatmospheric fistulae that developed after operations carried out for severe peritonitis, which was a consequence of sigmoid diverticulum rupture in two cases and disruption of an entero-enteric Roux-en-Y anastomosis after total gastrectomy for cancer in one.
   Results: All patients were appropriately supported in a surgical intensive care unit, with administration of total parenteral nutrition and appropriate antibiotics to eliminate secondary infections. Several re-operations were necessary to treat the enteroatmospheric fistulae. Eventually, all patients were discharged after a lengthy hospital stay (45-145 days).
   Conclusions: The essential principles of our operative strategy are: (1) early intervention; (2) a lateral surgical approach via the circumference of the open abdomen to avoid further damage to the exposed viscera; (3) excision of the involved bowel loop with an end-to-end anastomosis; (4) temporary abdominal closure and coverage of the open abdomen with an absorbable mesh, promoting tissue granulation; (5) skin grafting attempts; and (6) selective use of vacuum-assisted closure.
C1 [Marinis, Athanasios; Gkiokas, Georgios; Anastasopoulos, Georgios; Fragulidis, Georgios; Theodosopoulos, Theodosios; Kotsis, Thomas; Mastorakos, Dimitrios; Polymeneas, George; Voros, Dionisios] Univ Athens, Aretaie Univ Hosp, Dept Surg 2, Athens Med Sch, Athens 11528, Greece.
C3 National & Kapodistrian University of Athens
RP Voros, D (通讯作者)，Univ Athens, Aretaie Univ Hosp, Dept Surg 2, Athens Med Sch, 76 Vassilisis Sofias Ave, Athens 11528, Greece.
EM sakisdoc@yahoo.com
RI Gkiokas, Georgios/AAE-6312-2020; Marinis, Athanasios/AAO-2319-2020
OI Fragulidis, Georgios/0000-0001-6011-8674; Marinis,
   Athanasios/0000-0001-6423-6651
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Bosscha K, 2000, EUR J SURG, V166, P44
   Demetriades D, 2003, J TRAUMA, V55, P999, DOI 10.1097/01.TA.0000082493.55763.27
   Girard S, 2002, AM J SURG, V184, P166, DOI 10.1016/S0002-9610(02)00916-9
   Goverman J, 2006, J TRAUMA, V60, P428, DOI 10.1097/01.ta.0000203588.66012.c4
   Schecter WP, 2006, J AM COLL SURGEONS, V203, P390, DOI 10.1016/j.jamcollsurg.2006.06.001
   Smith LA, 1997, AM SURGEON, V63, P1102
   Subramaniam MH, 2002, J TRAUMA, V53, P386, DOI 10.1097/00005373-200208000-00037
NR 8
TC 18
Z9 19
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD FEB
PY 2009
VL 10
IS 1
BP 47
EP 52
DI 10.1089/sur.2008.044
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Infectious Diseases; Surgery
GA 612DM
UT WOS:000278877000006
PM 19245361
DA 2026-07-24
ER
PT J
AU Awad, SS
   Rao, RK
   Berger, DH
   Albo, D
   Bellows, CF
AF Awad, Samir S.
   Rao, Raghuram K.
   Berger, David H.
   Albo, Daniel
   Bellows, Charles F.
TI Microbiology of Infected Acellular Dermal Matrix (AlloDerm) in Patients
   Requiring Complex Abdominal Closure after Emergency Surgery
SO SURGICAL INFECTIONS
LA English
DT Article; Proceedings Paper
CT 26th Annual Meeting of the Surgical-Infection-Society
CY 2006
CL La Jolla, CA
SP Surg Infect Soc
ID SMALL-INTESTINAL SUBMUCOSA; REPAIR; MANAGEMENT; DEFECTS; HERNIA
AB Background: Acellular dermal matrix (AlloDerm) has recently been introduced as an option for complex abdominal closure for patients with loss of abdominal wall domain secondary to intra-abdominal sepsis or necrotizing fasciitis. AlloDerm has been touted as a promoter of neovascularization and collagen deposition. Currently, the rate of AlloDerm infection in contaminated cases is unknown. Our objective was to determine if the organisms cultured during source control would infect AlloDerm.
   Methods: The medical records of patients who required complex abdominal closure with AlloDerm in a tertiary-care hospital were reviewed from January to December, 2005. For each patient demographic, the reason for urgent surgery, American Society of Anesthesiologists (ASA) class, Acute Physiology and Chronic Health Evaluation (APACHE) II score, serum albumin concentration, culture results of purulent fluid obtained during surgery, and culture results of biopsies of infected-appearing AlloDerm (change of color, delayed granulation, odor) were collected. Data are presented as mean +/- standard error of the mean.
   Results: Seventeen patients required the use of AlloDerm for tension-free closure of the abdominal wall after surgery for source control in necrotizing fasciitis (13%) or intra-abdominal sepsis (87%). The mean age was 61 +/- 2 years; 73% of the patients were Caucasian, the remainder being African American. The mean APACHE II score was 23.7 +/- 2.0, and the median ASA class was 3. The mean preoperative albumin concentration was 2.27 +/- 0.26 g/dL. Most (76%) of the patients had a wound vacuum-assisted closure system placed over the AlloDerm. Four patients (24%) were noted to have an infection of the AlloDerm graft at 24 +/- 10 days postoperatively. The cultures obtained at operation and from infected AlloDerm show similar organisms (Pseudomonas in two, Escherichia coli and methicillin-resistant Staphylococcus aureus in one each). Infected AlloDerm was coated with silver sulfadiazene and moistened dressings, and all four patients had complete resolution of the Allo-Derm infection with an adequate bed of granulation tissue, allowing skin grafting.
   Conclusion: Patients with contaminated abdomens who require complex closure with AlloDerm are at risk of developing infection of their graft material with organisms similar to those present at the time of surgery. Once culture results are obtained, topical antimicrobials with activity against the cultured organisms may be employed as part of the AlloDerm dressings to prevent infection and promote healing.
C1 [Awad, Samir S.; Rao, Raghuram K.; Berger, David H.; Albo, Daniel; Bellows, Charles F.] Baylor Coll Med, Michael E DeBakey Dept Surg, MED VAMC, Houston, TX 77030 USA.
C3 Baylor College of Medicine
RP Awad, SS (通讯作者)，Baylor Coll Med, Michael E DeBakey Dept Surg, MED VAMC, OCL 112,RM 5A-344,2002 Holcombe Blvd, Houston, TX 77030 USA.
EM sawad@bcm.tmc.edu
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
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NR 16
TC 18
Z9 19
U1 0
U2 7
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
J9 SURG INFECT
JI Surg. Infect.
PD FEB
PY 2009
VL 10
IS 1
BP 79
EP 84
DI 10.1089/sur.2008.082
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Infectious Diseases; Surgery
GA 612DM
UT WOS:000278877000011
PM 19298171
DA 2026-07-24
ER
PT J
AU Younan, G
   Ogawa, R
   Ramirez, M
   Helm, D
   Dastouri, P
   Orgill, DP
AF Younan, George
   Ogawa, Rei
   Ramirez, Michelle
   Helm, Douglas
   Dastouri, Pouya
   Orgill, Dennis P.
TI Analysis of Nerve and Neuropeptide Patterns in Vacuum-Assisted
   Closure-Treated Diabetic Murine Wounds
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID GROWTH-FACTOR; PRESSURE ULCERS; SKIN; INFLAMMATION; NEUROPATHY; MICE;
   FOOT; ANGIOGENESIS; TISSUE; SCAR
AB Background: Reestablishment of the peripheral nervous system occurs in parallel with wound healing. With accelerated wound healing seen with the vacuum-assisted closure device, the authors studied its effects on nerve fiber regeneration, nerve sprouting, and the stimulation of neuropeptides and neurotrophins.
   Methods: A vacuum-assisted closure device was applied to a full-thickness diabetic mouse wound using continuous or cyclical modes and compared with foam dressing or occlusive dressing controls, using 10 mice per group. Nerve fibers, substance P, calcitonin gene-related peptide, and nerve growth factor were analyzed using two-dimensional immunohistochemistry and real-time reverse-transcriptase polymerase chain reaction.
   Results: A significant increase in dermal and epidermal nerve fiber densities and in substance P, calcitonin gene-related peptide, and nerve growth factor expression was seen in vacuum-assisted closure treated wounds. Cyclical treatment mode correlated with the largest increase in granulation tissue production, wound surface microdeformations, and a slightly faster wound closure rate.
   Conclusions: This study suggests that vacuum-assisted closure therapy can modulate nerve fiber and neuropeptide production in the wound. Optimized kinetics of vacuum-assisted closure application may provide an opportunity for clinicians to further improve wound healing in denervated wounds such as pressure sores and diabetic foot ulcerations. (Plast. Reconstr. Surg. 126: 87, 2010.)
C1 [Orgill, Dennis P.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast Surg, Boston, MA 02115 USA.
   Nippon Med Sch, Dept Plast Reconstruct & Aesthet Surg, Tokyo 113, Japan.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Nippon Medical School
RP Orgill, DP (通讯作者)，Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310; Younan, George/0000-0001-8502-4850
FU Kinetic Concepts, Inc., San Antonio, Texas
FX Dr. Orgill is the principal investigator on studies receiving research
   grants to the Brigham and Women's Hospital by Kinetic Concepts, Inc.,
   San Antonio, Texas, and is also an expert witness for Kinetic Concepts,
   Inc. The bioreactor used in this study, suction apparatus, and foam were
   provided by Kinetic Concepts, Inc. The other authors have no financial
   conflicts of interest and do not have any financial or business liaison,
   to Kinetic Concepts, Inc.
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NR 38
TC 40
Z9 52
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUL
PY 2010
VL 126
IS 1
BP 87
EP 96
DI 10.1097/PRS.0b013e3181da86d0
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 614ZD
UT WOS:000279097500011
PM 20595860
DA 2026-07-24
ER
PT J
AU Avery, CME
AF Avery, C. M. E.
TI Review of the radial free flap: is it still evolving, or is it facing
   extinction? Part one: soft-tissue radial flap
SO BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
LA English
DT Review
DE Radial flap; Morbidity; Donor site; Fasciocutaneous; Septocutaneous;
   Skin graft; Negative pressure wound dressing
ID ANTEROLATERAL THIGH FLAP; FOREARM FREE-FLAP; DONOR-SITE MORBIDITY;
   FULL-THICKNESS SKIN; VACUUM-ASSISTED CLOSURE; MAJOR MYOCUTANEOUS FLAP;
   ARM FREE-FLAP; NECK RECONSTRUCTION; SUPRAFASCIAL DISSECTION;
   MAXILLOFACIAL RECONSTRUCTION
AB The versatile fasciocutaneous radial flap is robust and reliable, straightforward to harvest, and often produces a satisfactory reconstruction with relatively little long-term morbidity at the donor site. Many surgeons prefer to use a limited number of trusted flaps, and these qualities will ensure that in the intermediate future most surgical trainees will continue to be shown the fasciocutaneous radial flap as both the basic training flap and the established option for reconstruction. Evidence from observational clinical studies and one randomised clinical trial indicates that there is increasing support for the use of the evolutionary technique of suprafascial dissection to minimise morbidity at the donor site. The suprafascial donor site may be repaired with either a meshed or unmeshed partial-thickness skin graft, or a fenestrated full-thickness skin graft, with good rates of successful healing. The application of a negative pressure dressing to the wound seems to facilitate the healing of all types of skin graft. The subfascial donor site, however, remains more prone to complications. It may be helpful to position the donor site of the flap more proximally, but this has not been proven. These refinements probably produce the best outcomes that can currently be achieved. given the inherent Haws of the radial donor site. (C) 2009 The British Association of Oral and Maxillolacial Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 Univ Hosp Leicester, Leicester LE1 5WW, Leics, England.
C3 University Hospitals of Leicester NHS Trust; University of Leicester
RP Avery, CME (通讯作者)，Univ Hosp Leicester, Leicester LE1 5WW, Leics, England.
EM chrisavery@doctors.org.uk
RI /AAI-1364-2019
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NR 122
TC 47
Z9 53
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0266-4356
EI 1532-1940
J9 BRIT J ORAL MAX SURG
JI Br. J. Oral Maxillofac. Surg.
PD JUN
PY 2010
VL 48
IS 4
BP 245
EP 252
DI 10.1016/j.bjoms.2009.09.004
PG 8
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 615HV
UT WOS:000279126300001
PM 19837491
DA 2026-07-24
ER
PT J
AU Kinoshita, O
   Nishimura, T
   Kawata, M
   Ando, M
   Kyo, S
   Ono, M
AF Kinoshita, Osamu
   Nishimura, Takashi
   Kawata, Mitsuhiro
   Ando, Masahiko
   Kyo, Shunei
   Ono, Minoru
TI Vacuum-assisted closure with Safetac technology for mediastinitis in
   patients with a ventricular assist device
SO JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
C1 [Kinoshita, Osamu; Kawata, Mitsuhiro; Ando, Masahiko; Ono, Minoru] Univ Tokyo, Dept Cardiothorac Surg, Bunkyo Ku, Tokyo 1138655, Japan.
   [Nishimura, Takashi; Kyo, Shunei] Univ Tokyo, Dept Therapeut Strategy Heart Failure, Tokyo 1138655, Japan.
C3 University of Tokyo; University of Tokyo
RP Kinoshita, O (通讯作者)，Univ Tokyo, Dept Cardiothorac Surg, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM osamu-k@umin.ac.jp
CR Dykes P J, 2001, J Wound Care, V10, P7
   Dykes P J, 2007, J Wound Care, V16, P97
   Marggraf G, 1999, EUR J SURG, V163, P12
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
NR 4
TC 11
Z9 12
U1 0
U2 0
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1434-7229
EI 1619-0904
J9 J ARTIF ORGANS
JI J. Artif. Organs
PD JUL
PY 2010
VL 13
IS 2
BP 126
EP 128
DI 10.1007/s10047-010-0500-5
PG 3
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA 615JI
UT WOS:000279130500011
PM 20376513
DA 2026-07-24
ER
PT J
AU Kang, GCW
   Por, YC
   Tan, BK
AF Kang, Gavin Chun-Wui
   Por, Yong Chen
   Tan, Bien-Keem
TI In Vivo Tissue Engineering Over Wounds With Exposed Bone and Tendon
   Autologous Dermal Grafting and Vacuum-assisted Closure
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE autologous dermis graft; vacuum-assisted closure; wound; exposed bone;
   joint and tendon; in vivo tissue engineering
ID MANAGEMENT; THERAPY
AB Flap coverage is ideal for wounds exposing bone and tendon, but technically less demanding and speedier options might be considered for small shallow wounds and for wounds with adjacent tissue loss precluding local flaps. We revisited the use of autologous dermal grafting-in combination with vacuum-assisted closure (VAC)-for such wounds.
   Five small-to medium-sized wounds exposing bone, joint, and/or tendon were each covered using an autologous meshed dermal graft followed by VAC application to induce granulation. Closure was completed at 2 weeks by split-thickness skin grafting over the granulating dermis graft.
   Complete and stable wound healing was achieved in all cases within 4 weeks of dermal grafting over exposed bone with excellent outcome at 1 year in terms of donor site healing and return to function. All healed wounds had a nearly flush profile with no bulkiness in the foot and toe region.
   Autologous dermal grafting with VAC is an integrated in vivo tissue engineering system in which the meshed dermis acts as an attractive scaffold for granulation within the conducive VAC-medium. As an alternative to flap surgery or dermal substitutes, the technique is simple, swift, and cost-effective for immediate closure of small shallow wounds and even multiple small wounds, exposing bone and tendon particularly in the lower legs, feet, and toes.
C1 [Kang, Gavin Chun-Wui; Por, Yong Chen; Tan, Bien-Keem] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 169608, Singapore.
C3 Singapore General Hospital
RP Tan, BK (通讯作者)，Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
EM bienkeem@singnet.com.sg
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brandi C, 2008, J PLAST RECONSTR AES, V61, P1507, DOI 10.1016/j.bjps.2007.09.036
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
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   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
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NR 10
TC 23
Z9 27
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUL
PY 2010
VL 65
IS 1
BP 70
EP 73
DI 10.1097/SAP.0b013e3181a72f77
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 616YB
UT WOS:000279246300017
PM 20548234
DA 2026-07-24
ER
PT J
AU Insausti, CL
   Alcaraz, A
   García-Vizcaíno, EM
   Mrowiec, A
   López-Martínez, MC
   Blanquer, M
   Piñero, A
   Majado, MJ
   Moraleda, JM
   Castellanos, G
   Nicolás, FJ
AF Insausti, Carmen L.
   Alcaraz, Antonia
   Garcia-Vizcaino, Eva M.
   Mrowiec, Anna
   Lopez-Martinez, Maria C.
   Blanquer, Miguel
   Pinero, Antonio
   Majado, Maria J.
   Moraleda, Jose M.
   Castellanos, Gregorio
   Nicolas, Francisco J.
TI Amniotic membrane induces epithelialization in massive posttraumatic
   wounds
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID STEM-CELLS; TERM PLACENTA; C-JUN; TRANSPLANTATION; SKIN; EXPRESSION;
   AP-1; DIFFERENTIATION; ACTIVATION; ULCERS
AB Large-surface or deep wounds often become senescent in the inflammatory or proliferation stages and cannot progress to reepithelialization. This failure makes intervention necessary to provide the final sealing epithelial layer. The best current treatment is autologous skin graft, although there are other choices such as allogenic or autologous skin substitutes and synthetic dressings. Amniotic membrane (AM) is a tissue of interest as a biological dressing due to its biological properties and immunologic characteristics. It has low immunogenicity and beneficial reepithelialization effects, with antiinflammatory, antifibrotic, antimicrobial, and nontumorigenic properties. These properties are related to its capacity to synthesize and release cytokines and growth factors. We report the use of AM as a wound dressing in two patients with large and deep traumatic wounds. Negative pressure wound therapy followed by AM application was capable of restoring skin integrity avoiding the need for skin graft reconstruction. AM induced the formation of a well-structured epidermis. To understand this effect, we designed some assays on human keratinocyte-derived HaCaT cells. AM treatment of HaCaT induced ERK1/2 and SAP/JNK kinases phosphorylation and c-jun expression, a gene critical for keratinocytes migration; however, it did not affect cell cycle distribution. These data suggest that AM substantially modifies the behavior of keratinocytes in chronic wounds, thereby allowing effective reepithelialization.
C1 [Alcaraz, Antonia; Garcia-Vizcaino, Eva M.; Mrowiec, Anna; Lopez-Martinez, Maria C.; Nicolas, Francisco J.] Hosp Univ Virgen Arrixaca, Unidad Invest, Oncol Mol & TGF, Murcia 30120, Spain.
   [Pinero, Antonio; Castellanos, Gregorio] Hosp Univ Virgen Arrixaca, Serv Cirugia, Murcia, Spain.
   [Insausti, Carmen L.; Blanquer, Miguel; Majado, Maria J.; Moraleda, Jose M.] Hosp Univ Virgen Arrixaca, Unidad Terapia Celular, Murcia, Spain.
C3 Hospital Clinico Universitario Virgen de la Arrixaca; Hospital Clinico
   Universitario Virgen de la Arrixaca; Hospital Clinico Universitario
   Virgen de la Arrixaca
RP Nicolás, FJ (通讯作者)，Hosp Univ Virgen Arrixaca, Unidad Invest, Oncol Mol & TGF, Crta Madrid Cartagena S-N, Murcia 30120, Spain.
EM franciscoj.nicolas2@carm.es
RI Blanquer Blanquer, Miguel/B-8732-2008; Nicolás, Francisco
   José/H-9422-2019; Moraleda, Jose M/AAB-4119-2020; López-Martínez,
   Carlos/J-7446-2012; Piñero-Madrona, Antonio/AAB-5138-2022
OI Blanquer Blanquer, Miguel/0000-0002-1471-8828; Nicolás, Francisco
   José/0000-0002-3969-1430; Moraleda, Jose M/0000-0001-9080-1466;
   López-Martínez, Carlos/0000-0002-1366-9446; Mrowiec,
   Anna/0000-0001-8745-5494; Piñero-Madrona, Antonio/0000-0002-7718-8318
FU Spanish Ministry of Education and Science; Fundacion Seneca de la Region
   de Murcia; Instituto de Salud Carlos III; Fondo de Investigaciones
   Sanitarias; Hospital Universitario Virgen de la Arrixaca
FX This work was supported by a grant from the Spanish Ministry of
   Education and Science, a grant from the Fundacion Seneca de la Region de
   Murcia, and a grant from the Instituto de Salud Carlos III, Fondo de
   Investigaciones Sanitarias. E.M.G.V. was supported by a student grant
   from de Fundacion Seneca de la Region de Murcia. F.J.N. was supported by
   the Ramon y Cajal program of the Spanish Ministry for Education and
   Science. We are indebted to the Hospital Universitario Virgen de la
   Arrixaca, which strongly supported this research.
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NR 36
TC 74
Z9 82
U1 0
U2 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1067-1927
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2010
VL 18
IS 4
BP 368
EP 377
DI 10.1111/j.1524-475X.2010.00604.x
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 619UB
UT WOS:000279454700077
PM 20636551
DA 2026-07-24
ER
PT J
AU Stannard, JP
   Singanamala, N
   Volgas, DA
AF Stannard, James P.
   Singanamala, Naveen
   Volgas, David A.
TI Fix and flap in the era of vacuum suction devices: What do we know in
   terms of evidence based medicine?
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE Negative pressure wound therapy (NPWT); Vacuum-assisted closure (VAC);
   Open fracture; Wound coverage
ID OPEN TIBIAL FRACTURES; ASSISTED CLOSURE THERAPY; PRESSURE WOUND THERAPY;
   SOFT-TISSUE INJURIES; NEGATIVE-PRESSURE; SUBATMOSPHERIC PRESSURE;
   BLOOD-FLOW; TEMPORARY TREATMENT; SHAFT FRACTURES; MANAGEMENT
AB Introduction: The concept of immediate or early fixation and soft tissue coverage of open fractures is frequently referred to as 'fix and flap,' and negative pressure wound therapy (NPWT) has had a major impact in this area. This article aims to review concepts and evidence relevant to the use of NPWT in open fractures.
   Review of open fracture management: Muscle flaps in open fractures do well in part because they improve blood supply to the underlying fracture. Outcomes of muscle flaps are best when done acutely, before bacterial colonisation. The colonised subacute wound is managed with 'open-wound techniques' until it becomes a chronic localised wound, when flap coverage is again indicated. NPWT provides a useful adjunct in this process as the zone of injury is determined.
   Vacuum-assisted closure review of basic and clinical science literature: Proposed mechanisms of action of NPWT include: increased blood flow, decreased oedema, cytokine release induced by mechanical stretch and increased lactate and oxygen tension in the tissue with induction of collagen transcription and angiogenesis.
   Vacuum-assisted closure in open fractures: NPWT to open fractures caused early appearance of healthy granulation tissue, a reduction in wound area and allowed simpler soft tissue procedures for wound closure. NPWT also improved clinical survival of muscle flaps despite occluded flap venous outflow.
   Summary: The aim in open fractures is to stabilize the fracture and achieve soft tissue coverage before infection develops. NPWT, applied as a temporizing dressing, simplifies soft tissue coverage on the 'reconstructive ladder.' The only Level-I data on that topic showed a significant decrease in infections. However, NPWT does not allow delay in soft tissue coverage. NPWT increases the 'take rate' of skin grafts, skin substitutes and composite skin grafts and allows quicker graft incorporation. (C) 2010 Published by Elsevier Ltd.
C1 [Stannard, James P.; Singanamala, Naveen; Volgas, David A.] Univ Alabama Birmingham, Sect Orthopaed Trauma, Orthopaed Div, Dept Surg, Birmingham, AL 35294 USA.
   [Stannard, James P.] Univ Missouri Hosp, Dept Orthopaed Surg, Columbia, MO 65212 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Missouri System; University of Missouri Columbia
RP Stannard, JP (通讯作者)，Univ Alabama Birmingham, Sect Orthopaed Trauma, Orthopaed Div, Dept Surg, 510 S 20th St,FOT 950, Birmingham, AL 35294 USA.
EM James.Stannard@ortho.uab.edu
OI Volgas, David/0000-0003-2050-185X; Stannard, James P/0000-0001-8467-6494
FU Kinetic Concepts Inc., San Antonio, TX
FX Research funding support for this project was provided by Kinetic
   Concepts Inc., San Antonio, TX.
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NR 49
TC 69
Z9 92
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD AUG
PY 2010
VL 41
IS 8
BP 780
EP 786
DI 10.1016/j.injury.2009.08.011
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 620TL
UT WOS:000279522800002
PM 20471012
DA 2026-07-24
ER
PT J
AU Danks, RR
   Lairet, K
AF Danks, Roy R.
   Lairet, Kimberly
TI Innovations in Caring for a Large Burn in the Iraq War Zone
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID VIENNESE CONCEPT; MEEK
AB The authors report on a single case of a large, civilian burn cared for at a U.S. military hospital during Operation Iraqi Freedom. The management of the patient, using a large negative pressure wound therapy device and the Meek grafting technique, is reviewed. This is a case report. The patient survived his injury. In Iraq, most patients with this severity of injury succumb to the injury. By using two innovative techniques, the authors found that the patient was able to survive his injury and return to his home. (J Burn Care Res 2010; 31: 665-669)
C1 [Danks, Roy R.; Lairet, Kimberly] USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA.
RP Danks, RR (通讯作者)，1001 6th Ave,Ste 230, Leavenworth, KS 66048 USA.
CR *AM BURN ASS, NAT BURN REP 2008 RE
   BERGMANN J, 2009, J BURN CARE RES S, V29, pS58
   Lumenta DB, 2009, J BURN CARE RES, V30, P231, DOI 10.1097/BCR.0b013e318198a2d6
   MEEK CP, 1958, AM J SURG, V96, P557, DOI 10.1016/0002-9610(58)90975-9
   Roka J, 2007, HANDCHIR MIKROCHIR P, V39, P322, DOI 10.1055/s-2007-965324
NR 5
TC 20
Z9 21
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2010
VL 31
IS 4
BP 665
EP 669
DI 10.1097/BCR.0b013e3181e4c8aa
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 622DC
UT WOS:000279638400020
PM 20523231
DA 2026-07-24
ER
PT J
AU Petzina, R
   Hoffmann, J
   Navasardyan, A
   Malmsjö, M
   Stamm, C
   Unbehaun, A
   Hetzer, R
AF Petzina, Rainer
   Hoffmann, Julia
   Navasardyan, Artashes
   Malmsjo, Malin
   Stamm, Christof
   Unbehaun, Axel
   Hetzer, Roland
TI Negative pressure wound therapy for post-sternotomy mediastinitis
   reduces mortality rate and sternal re-infection rate compared to
   conventional treatment
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 23rd Annual Techno-College Meeting of the
   European-Association-for-Cardio-Thoracic-Surgery (EACTS)
CY OCT 17-21, 2009
CL Vienna, AUSTRIA
SP European Assoc Cardio Thorac Surg (EACTS)
DE Mediastinal infection; Wound healing; Cardiac surgery
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; CARDIAC-SURGERY; INFECTION;
   COMPLICATIONS; SURVIVAL
AB Objective: Negative pressure wound therapy (NPWT) is a recently introduced treatment modality for post-sternotomy mediastinitis. The aim of this study was to compare the mortality rate, the sternal re-infection rate and the length of hospital stay in patients with post-sternotomy mediastinitis after NPWT and conventional treatment. Methods: We retrospectively analysed 118 patients with post-sternotomy mediastinitis after cardiac surgery. One group of 69 patients was treated with NPWT and the other group of 49 patients with conventional therapy. Results: There were no major differences between the two groups concerning preoperative data (EuroScore) or primary cardiac surgery (mainly coronary artery bypass grafting). NPWT therapy was found to reduce mortality rate (P = 0.005) and sternal re-infection rate (P = 0.008) compared with conventional treatment and tended to lead to a shorter length of hospital stay (P = 0.08). Conclusions: NPWT for post-sternotomy mediastinitis demonstrates encouraging clinical results with a reduction of the mortality rate and the sternal re-infection rate compared with conventional treatment. The results support NPWT as the first-line treatment for deep sternal wound infections. (C) 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
C1 [Petzina, Rainer; Hoffmann, Julia; Navasardyan, Artashes; Stamm, Christof; Unbehaun, Axel; Hetzer, Roland] Deutsch Herzzentrum Berlin, D-13353 Berlin, Germany.
   [Malmsjo, Malin] Univ Lund Hosp, S-22185 Lund, Sweden.
C3 German Heart Center Berlin; Lund University; Skane University Hospital
RP Petzina, R (通讯作者)，Deutsch Herzzentrum Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM petzina@dhzb.de
RI ; Unbehaun, Axel/IYS-3471-2023; Stamm, Christof/J-5719-2014
OI Maljö, Malin/0000-0001-9849-9599; Petzina, Rainer/0000-0002-0688-5482;
   Unbehaun, Axel/0000-0003-2851-695X; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Cowan KN, 2005, ANN THORAC SURG, V80, P2205, DOI 10.1016/j.athoracsur.2005.04.005
   Doss M, 2002, EUR J CARDIO-THORAC, V22, P934, DOI 10.1016/S1010-7940(02)00594-8
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Fleischmann W, 1996, UNFALLCHIRURG, V99, P283
   JURKIEWICZ MJ, 1980, ANN SURG, V191, P738, DOI 10.1097/00000658-198006000-00012
   Kadohama T, 2008, ANN THORAC SURG, V85, P1094, DOI 10.1016/j.athoracsur.2007.09.004
   LEE AB, 1976, SURGERY, V80, P433
   Lu JCY, 2003, EUR J CARDIO-THORAC, V23, P943, DOI 10.1016/S1010-7940(03)00137-4
   Mokhtari A, 2008, SCAND CARDIOVASC J, V42, P85, DOI 10.1080/14017430701744469
   Mokhtari A, 2006, ANN THORAC SURG, V82, P1063, DOI 10.1016/j.athoracsur.2006.04.085
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Petzina R, 2006, EUR J CARDIO-THORAC, V30, P85, DOI 10.1016/j.ejcts.2006.04.009
   Ridderstolpe L, 2001, EUR J CARDIO-THORAC, V20, P1168, DOI 10.1016/S1010-7940(01)00991-5
   SHUMACKER HB, 1963, ARCH SURG-CHICAGO, V86, P384
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
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   Wetzel-Roth W, 2004, ZBL CHIR, V129, pS7, DOI 10.1055/s-2004-822677
NR 18
TC 65
Z9 82
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD JUL
PY 2010
VL 38
IS 1
BP 110
EP 113
DI 10.1016/j.ejcts.2010.01.028
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 623ML
UT WOS:000279744400020
PM 20171898
OA Bronze
DA 2026-07-24
ER
PT J
AU Durai, R
   Ng, PCH
AF Durai, R.
   Ng, P. C. H.
TI Novel combination Combining J-VAC® and VAC® sponge for draining a rectal
   wound
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE Rectal wound; VAC; negative pressure therapy: stapled haemorrhoidectomy
ID ANASTOMOTIC LEAKAGE; SEPSIS
AB Active drains, which work by negative pressure, require a closed space for retaining the vacuum. Here the authors describe their novel technique of combining a J-Vac (R) drain and the sponge of a vacuum assisted closure dressing pack to drain a rectal wound. This modification may be useful for rectal wounds and anastomotic leaks.
C1 [Durai, R.; Ng, P. C. H.] Univ Hosp Lewisham, Dept Surg, London SE13 6LH, England.
C3 University of London; King's College London
RP Durai, R (通讯作者)，Univ Hosp Lewisham, Dept Surg, London SE13 6LH, England.
EM dr_durai@yahoo.com
CR Durai R, 2009, TECH COLOPROCTOL, V13, P307, DOI 10.1007/s10151-009-0503-5
   McCloud JM, 2006, COLORECTAL DIS, V8, P748, DOI 10.1111/j.1463-1318.2006.01028.x
   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
   Nagell CF, 2006, INT J COLORECTAL DIS, V21, P657, DOI 10.1007/s00384-005-0083-4
   Van Koperen PJ, 2008, COLORECTAL DIS, V10, P943, DOI 10.1111/j.1463-1318.2008.01485.x
   Weidenhagen R, 2008, Rozhl Chir, V87, P397
NR 6
TC 1
Z9 1
U1 0
U2 1
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD JUN
PY 2010
VL 110
IS 3
BP 402
EP 404
DI 10.1080/00015458.2010.11680646
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 625GU
UT WOS:000279884100033
PM 20690536
DA 2026-07-24
ER
PT J
AU Fang, R
   Dorlac, WC
   Flaherty, SF
   Tuman, C
   Cain, SM
   Popey, TLC
   Villard, DR
   Aydelotte, JD
   Dunne, JR
   Anderson, AM
   Powell, ET
AF Fang, Raymond
   Dorlac, Warren C.
   Flaherty, Stephen F.
   Tuman, Caroline
   Cain, Steven M.
   Popey, Tracy L. C.
   Villard, Douglas R.
   Aydelotte, Jayson D.
   Dunne, James R.
   Anderson, Adam M.
   Powell, Elisha T.
TI Feasibility of Negative Pressure Wound Therapy During Intercontinental
   Aeromedical Evacuation of Combat Casualties
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Soft-tissue wounds; Aeromedical evacuation; Negative pressure; Military
   medicine; War; Wounds and injuries
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; EXPERIENCE; MANAGEMENT
AB Objective: The objective of this study was to assess the feasibility of utilizing negative pressure wound therapy (NPWT) for the treatment of wartime soft-tissue wounds during intercontinental aeromedical evacuation.
   Background: Attempts to use NPWT during early phases of overseas contingency operations resulted in occasional vacuum system failures and potentially contributed to wound complications. These anecdotal episodes led to a perception that NPWT during aeromedical evacuation carried a high risk of wound complications and limited its use. As a result, NPWT was not frequently applied in the management of soft-tissue wounds before US casualty arrival in the continental United States (CONUS) for wounds sustained in the combat theaters. Concurrently, early NPWT on the traumatic wounds of host nation casualties not requiring aeromedical evacuation seemed to provide many benefits typically associated with the therapy such as decreased infection rates, earlier wound closure, and improved pain management.
   Methods: On a daily basis, study investigators reviewed the trauma inpatient census at Landstuhl Regional Medical Center, Germany, to identify patient candidates with soft-tissue extremity or torso wounds that required packing. Patient demographics, injuries, and previous wound treatments were recorded. Surgeons inspected wounds in the operating room and applied a NPWT dressing if deemed appropriate. NPWT was continued throughout the remainder of the patient's hospitalization and also during aeromedical evacuation to CONUS. A study investigator escorted the patient during aeromedical evacuation to educate the flight crews, to record the impact on crew workload, and to troubleshoot the system if necessary.
   Results: Thirty enrolled patients with 41 separate wounds flew from Germany to CONUS with a portable NPWT system (VAC Freedom System; Kinetic Concepts Incorporated, San Antonio, TX). All 30 patients arrived at the destination facilities with intact and functional systems. No significant in-flight complications were identified, impact on flight crew workload was negligible, and subjective feedback from both flight crews and patients was uniformly positive. For 29 patients, the NPWT dressing was replaced (frequently with serial exchanges) during initial surgical treatment in CONUS; the 30th patient underwent delayed primary closure of his right forearm fasciotomy. Receiving care teams reported no complications attributable to NPWT during aeromedical vacuation.
   Conclusions: NPWT is feasible during intercontinental aeromedical evacuation of combat casualties without an increase in wound complications or a significant impact on air crew workload. Further studies are indicated to evaluate the efficacy of NPWT in combat wounds compared with other wound care techniques.
C1 [Fang, Raymond; Tuman, Caroline; Cain, Steven M.; Popey, Tracy L. C.; Villard, Douglas R.] Landstuhl Reg Med Ctr, Landstuhl, Germany.
   [Dorlac, Warren C.] Univ Cincinnati, Cincinnati, OH USA.
   [Flaherty, Stephen F.; Aydelotte, Jayson D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
   [Dunne, James R.] Natl Naval Med Ctr, Bethesda, MD USA.
   [Powell, Elisha T.] Alaska Reg Hosp, Anchorage, AK USA.
C3 Landstuhl Regional Medical Center; University System of Ohio; University
   of Cincinnati; United States Department of Defense; United States Army;
   Walter Reed National Military Medical Center; Walter Reed National
   Military Medical Center
RP Fang, R (通讯作者)，LRMC Trauma Program, CMR 402, APO, AE 09180 USA.
EM Raymond.Fang@amedd.army.mil
CR [Anonymous], 2004, WOUNDS, p3S
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
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   Routledge Tom, 2005, J Heart Lung Transplant, V24, P1444, DOI 10.1016/j.healun.2004.12.111
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NR 21
TC 34
Z9 37
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD JUL
PY 2010
VL 69
SU 1
BP S140
EP S145
DI 10.1097/TA.0b013e3181e452a2
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 627AC
UT WOS:000280009000021
PM 20622609
DA 2026-07-24
ER
PT J
AU Leung, BK
   LaBarbera, LA
   Carroll, CA
   Allen, D
   McNulty, AK
AF Leung, Braden K.
   LaBarbera, Lori A.
   Carroll, Christopher A.
   Allen, Diwi
   McNulty, Amy K.
TI The Effects of Normal Saline Instillation in Conjunction With Negative
   Pressure Wound Therapy on Wound Healing in a Porcine Model
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; SUBATMOSPHERIC
   PRESSURE; DEVICE; MULTICENTER; SWINE
AB Acute and chronic wounds impact the lives of millions of patients Since its introduction, negative pressure wound therapy using reticulated open cell foam (NPWT/ROCF). has significantly improved the healing outcome for many of these wounds Methods The effects of intermittent instillation of normal saline in conjunction with NPWT were investigated to determine if instillation therapy provides additional benefits in wound healing Conventional NPWT/ROCF as delivered by VA C (R) Therapy was compared to VA C Instill (R) Therapy with normal saline in the treatment of porcine full-thickness excisional wounds Wounds were treated with NPWT/ROCF or NPWT/ROCF with instillation therapy at approximately 4 cycles of normal saline instillation per day and dwell times of either 5 or 60 minutes for the instilled saline on the wound bed Results Instillation therapy with normal saline at either dwell time elicited a faster rate of wound filling with granulation tissue that contained an increase in total collagen content compared to continuous NPWT/ROCF alone Analyses of wound contraction and the hydration state of the treated tissue exhibited no apparent differences between the experimental instillation therapy groups and the control NIDWT/ROCF group Conclusion. Collectively, these data suggest that instillation therapy with normal saline may lead to wound fill with higher quality granulation tissue composed of increased collagen following wounding of cutaneous tissue compared to the use of NPWT/ROCF alone
C1 [Leung, Braden K.] KCI, Global Res & Dev, San Antonio, TX 78249 USA.
RP Leung, BK (通讯作者)，KCI, Global Res & Dev, 6203 Fannon Dr, San Antonio, TX 78249 USA.
FU Kinetic Concepts, Inc (KCI)
FX Financial support for execution of this study was provided by Kinetic
   Concepts, Inc (KCI)
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Whaley Susan, 2004, Br J Community Nurs, V9, P471
   Wolvos Tom, 2004, Ostomy Wound Manage, V50, P56
NR 29
TC 24
Z9 30
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2010
VL 22
IS 7
BP 179
EP 187
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 629FJ
UT WOS:000280180100004
PM 25901498
DA 2026-07-24
ER
PT J
AU Kumar, P
   Sharma, A
AF Kumar, Pramod
   Sharma, Ankur
TI The Limited Access Dressing for Damage Control in Trauma Patients
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; OPEN CELL FOAM;
   MANAGEMENT
AB The leeching effects of the Limited Access Dressing (LAD) effectively controls infection, reduces edema, promotes earlier physiotherapy, and helps to control secondary damage to trauma cases, which results in faster wound bed preparation reconstruction, and quicker rehabilitaion The following is a case series of 20 consecutive patients treated with LAD without specific controls. In eight cases bone was exposed in three cases tendon was exposed, in two cases both bone and tendon were exposed, and in one case an injured brachial artery was exposed Methods After saline wash, the LAD with intermittent negative pressure was applied (30 minutes negative pressure, 3 5-hour rest period) Wound debridement and physiotherapy were started on day 1 as necessary Second stage elective procedure was done after healthy granulation tissue had covered exposed tendon bone, and vessels. A split-thickness skin graft (SSG) was then applied to cover the wound Results Excellent graft take (> 99%) was seen in 18 of the 20 cases where skin grafting was done under LAD The time taken to prepare the wound for resurfacing (after skin grafting) was less than 6 weeks in the majority (16/18) of cases Post discharge physiotherapy to achieve maximum possible mobilization in upper extremity (10/20) cases was less than 6 weeks in most cases (6/10) The average cost of treatment was Rs 16071 00 (US $365) Conclusion LAD is an effective tool for damage control in trauma cases
C1 [Kumar, Pramod; Sharma, Ankur] Kasturba Med Coll & Hosp, Dept Plast Surg, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Kasturba Medical College,
   Manipal
RP Kumar, P (通讯作者)，Kasturba Med Coll & Hosp, Dept Plast Surg, Manipal 576104, Karnataka, India.
RI Kumar, Pramod/L-8280-2015
OI Kumar, Pramod/0000-0001-8831-1804
CR BONE RC, 1992, CHEST, V101, P1644, DOI 10.1378/chest.101.6.1644
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   Chambers HF, 2006, GOODMAN GILMANS PHAR, P1095
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NR 15
TC 5
Z9 7
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2010
VL 22
IS 7
BP 188
EP 192
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 629FJ
UT WOS:000280180100005
PM 25901497
DA 2026-07-24
ER
PT J
AU Negosanti, L
   Aceti, A
   Bianchi, T
   Corvaglia, L
   Negosanti, F
   Sgarzani, R
   Morselli, PG
   Cipriani, R
   Negosanti, M
   Patrizi, A
   Faldella, G
AF Negosanti, Luca
   Aceti, Arianna
   Bianchi, Tommaso
   Corvaglia, Luigi
   Negosanti, Francesca
   Sgarzani, Rossella
   Morselli, Paolo Giovanni
   Cipriani, Riccardo
   Negosanti, Massimino
   Patrizi, Annalisa
   Faldella, Giacomo
TI Adapting a Vacuum Assisted Closure dressing to challenging wounds:
   negative pressure treatment for perineal necrotizing fasciitis with
   rectal prolapse in a newborn affected by acute myeloid leukaemia
SO EUROPEAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE necrotizing fascitiis; negative pressure therapy; neonatal infection;
   vacuum assisted closure dressing; wound care
ID PSEUDOMONAS-AERUGINOSA; THERAPY; CHILDREN
AB We report the case of a newborn with acute myeloid leukaemia, who developed perineal necrotizing fasciitis due to Pseudomonas Aeruginosa, after twenty days of life. Following surgical debridement, she was effectively treated with topical negative pressure therapy (V.A.C.(R) device) with silver foam dressings, this achieved complete closure in thirteen days. Negative pressure therapy should be considered when conventional wound care fails to achieve complete wound closure, even in neonates.
C1 [Negosanti, Luca; Sgarzani, Rossella; Morselli, Paolo Giovanni; Cipriani, Riccardo] St Orsola Marcello Malpighi Hosp, Unit Plast Surg, I-40138 Bologna, Italy.
   [Aceti, Arianna; Corvaglia, Luigi; Faldella, Giacomo] St Orsola Marcello Malpighi Hosp, Unit Neonatol & Neonatal Intens Care, I-40138 Bologna, Italy.
   [Bianchi, Tommaso] Bellaria Maggiore Hosp, Unit Dermatol, Bologna, Italy.
   [Negosanti, Francesca; Negosanti, Massimino; Patrizi, Annalisa] St Orsola Marcello Malpighi Hosp, Unit Dermatol, I-40138 Bologna, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; IRCCS Azienda
   Ospedaliero-Universitaria di Bologna; AUSL di Bologna; IRCCS Azienda
   Ospedaliero-Universitaria di Bologna
RP Negosanti, L (通讯作者)，St Orsola Marcello Malpighi Hosp, Unit Plast Surg, Via Massarenti 9, I-40138 Bologna, Italy.
EM luca.negosanti81@gmail.com
RI ; Aceti, Arianna/AAB-4007-2019; Negosanti, Luca/AAF-1605-2020; Sgarzani,
   Rossella/M-7495-2018
OI Annalisa, Patrizi/0000-0002-8398-0483; Aceti,
   Arianna/0000-0001-9274-985X; Negosanti, Luca/0000-0002-8110-3604;
   Sgarzani, Rossella/0000-0002-5543-8013; Negosanti,
   Massimino/0000-0001-8754-9992
CR Baharestani MM, 2007, OSTOMY WOUND MANAG, V53, P75
   Bingöl-Kologlu M, 2007, J PEDIATR SURG, V42, P1892, DOI 10.1016/j.jpedsurg.2007.07.018
   European Wound Management Association (EWMA), 2006, Position Document: Management of wound infection
   *EWMA, 2007, POS DOC TOP NEG PRES
   Jaing TH, 2001, J PEDIATR SURG, V36, P948, DOI 10.1053/jpsu.2001.23998
   Labler L, 2006, ZBL CHIR, V131, pS62
   Lo WT, 2005, EUR J PEDIATR, V164, P113, DOI 10.1007/s00431-004-1554-2
   McCord SS, 2007, WOUND REPAIR REGEN, V15, P296, DOI 10.1111/j.1524-475X.2007.00229.x
   Moss RLM, 1996, J PEDIATR SURG, V31, P1142, DOI 10.1016/S0022-3468(96)90104-9
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   Zuloaga-Salcedo Soraya, 2005, Int Wound J, V2, P178, DOI 10.1111/j.1742-4801.2005.00104.x
NR 13
TC 12
Z9 12
U1 0
U2 9
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 1167-1122
EI 1952-4013
J9 EUR J DERMATOL
JI Eur. J. Dermatol.
PD JUL-AUG
PY 2010
VL 20
IS 4
BP 501
EP 503
DI 10.1684/ejd.2010.0964
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 631LO
UT WOS:000280348700015
PM 20406723
DA 2026-07-24
ER
PT J
AU Hsu, CC
   Tsai, WC
   Chen, CPC
   Lu, YM
   Wang, JS
AF Hsu, Chih-Chin
   Tsai, Wen-Chung
   Chen, Carl Pai-Chu
   Lu, Yun-Mei
   Wang, Jong-Shyan
TI Effects of negative pressures on epithelial tight junctions and
   migration in wound healing
SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
LA English
DT Article
DE negative-pressure wound therapy; electric impedance; cell junctions;
   cell movement
ID VACUUM-ASSISTED CLOSURE; CELL-MIGRATION; GROWTH-FACTOR; THERAPY;
   PROLIFERATION; HYPOXIA; MATRIX; MECHANISM; ULCERS; TRIAL
AB Hsu CC, Tsai WC, Chen CP, Lu YM, Wang JS. Effects of negative pressures on epithelial tight junctions and migration in wound healing. Am J Physiol Cell Physiol 299: C528-C534, 2010. First published May 5, 2010; doi: 10.1152/ajpcell.00504.2009.-Negative-pressure wound therapy has recently gained popularity in chronic wound care. This study attempted to explore effects of different negative pressures on epithelial migration in the wound-healing process. The electric cell-substrate impedance sensing (ECIS) technique was used to create a 5 x 10(-4) cm(2) wound in the Madin-Darby canine kidney (MDCK) and human keratinocyte (HaCaT) cells. The wounded cells were cultured in a negative pressure incubator at ambient pressure (AP) and negative pressures of 75 mmHg (NP75), 125 mmHg (NP125), and 175 mmHg (NP175). The effective time (ET), complete wound healing time (T-max), healing rate (R-heal), cell diameter, and wound area over time at different pressures were evaluated. Traditional wound-healing assays were prepared for fluorescent staining of cells viability, cell junction proteins, including ZO-1 and E-cadherin, and actins. Amount of cell junction proteins at AP and NP125 was also quantified. In MDCK cells, the ET (1.25 +/- 0.27 h), T-max (1.76 +/- 0.32 h), and R-heal (2.94 +/- 0.62 x 10(-4) cm(2)/h) at NP125 were significantly (P < 0.01) different from those at three other pressure conditions. In HaCaT cells, the T-max (7.34 +/- 0.29 h) and R-heal (6.82 +/- 0.26 x 10(-5) cm(2)/h) at NP125 were significantly (P < 0.01) different from those at NP75. Prominent cell migration features were identified in cells at the specific negative pressure. Cell migration activities at different pressures can be documented with the real-time wound-healing measurement system. Negative pressure of 125 mmHg can help disassemble the cell junction to enhance epithelial migration and subsequently result in quick wound closure.
C1 [Hsu, Chih-Chin; Tsai, Wen-Chung; Lu, Yun-Mei; Wang, Jong-Shyan] Chang Gung Univ, Grad Inst Rehabil Sci, Coll Med, Tao Yuan 333, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Chilung, Taiwan.
   [Hsu, Chih-Chin; Tsai, Wen-Chung] Chang Gung Univ, Sch Tradit Chinese Med, Tao Yuan 333, Taiwan.
   [Tsai, Wen-Chung; Chen, Carl Pai-Chu] Chang Gung Mem Hosp Linkou, Dept Phys Med & Rehabil, Tao Yuan, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital
RP Wang, JS (通讯作者)，Chang Gung Univ, Grad Inst Rehabil Sci, Coll Med, 259 Wen Hwa 1st Rd, Tao Yuan 333, Taiwan.
EM s5492@mail.cgu.edu.tw
OI Wang, Jong-Shyan/0000-0002-3095-9357
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NR 37
TC 38
Z9 48
U1 1
U2 17
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6143
EI 1522-1563
J9 AM J PHYSIOL-CELL PH
JI Am. J. Physiol.-Cell Physiol.
PD AUG
PY 2010
VL 299
IS 2
BP C528
EP C534
DI 10.1152/ajpcell.00504.2009
PG 7
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 632CK
UT WOS:000280397600036
PM 20445172
DA 2026-07-24
ER
PT J
AU Al-Mufarrej, F
   Margolis, M
   Tempesta, B
   Strother, E
   Gharagozloo, F
AF Al-Mufarrej, Faisal
   Margolis, Marc
   Tempesta, Barbara
   Strother, Eric
   Gharagozloo, Farid
TI Outpatient Management of Post-Pneumonectomy and Post-Lobectomy Empyema
   Using the Vacuum-Assisted Closure System
SO SURGERY TODAY
LA English
DT Article
DE Vacuum-assisted closure; Empyema; Pneumonectomy
ID WOUNDS; DEVICE
AB The goal of this study was to analyze the patterns, therapeutic modalities, and short-term outcomes of patients with chest injuries in the aftermath of the Wen-Chuan earthquake, which occurred on May 12, 2008 and registered 8.0 on the Richter scale.
   Of the 1522 patients who were referred to the West China Hospital of Sichuan University from May 12 to May 27, 169 patients (11.1%) had suffered major chest injuries. The type of injury, the presence of infection, Abbreviated Injury Score (AIS 2005), New Injury Severity Score (NISS), treatment, and short-term outcome were all documented for each case.
   Isolated chest injuries were diagnosed in 129 patients (76.3%), while multiple injuries with a major chest trauma were diagnosed in 40 patients (23.7%). The mean AIS and the median NISS of the hospitalized patients with chest injuries were 2.5 and 13, respectively. The mortality rate was 3.0% (5 patients).
   Most of the chest injuries were classified as minor to moderate trauma; however, coexistent multiple injuries and subsequent infection should be carefully considered in medical response strategies. Coordinated efforts among emergency medical support groups and prior training in earthquake preparedness and rescue in earthquake-prone areas are therefore necessary for efficient evacuation and treatment of catastrophic casualties.
C1 [Al-Mufarrej, Faisal; Margolis, Marc; Strother, Eric; Gharagozloo, Farid] George Washington Univ, Med Ctr, Washington, DC 20037 USA.
   [Margolis, Marc; Tempesta, Barbara; Gharagozloo, Farid] Washington Inst Thorac & Cardiovasc Surg, Washington, DC USA.
C3 George Washington University
RP Al-Mufarrej, F (通讯作者)，George Washington Univ, Med Ctr, 2300 Eye St NW, Washington, DC 20037 USA.
CR Matzi V, 2007, ANN THORAC SURG, V84, P1762, DOI 10.1016/j.athoracsur.2007.05.052
   Morykwas M. J., 1997, ANN PLAST SURG, V38, P563
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   O'Connor J, 2005, ANN THORAC SURG, V79, P1196, DOI 10.1016/j.athoracsur.2004.09.041
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
NR 6
TC 14
Z9 16
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
J9 SURG TODAY
JI Surg. Today
PD AUG
PY 2010
VL 40
IS 8
BP 711
EP 718
DI 10.1007/s00595-008-4096-9
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 634KI
UT WOS:000280579400005
PM 20676853
DA 2026-07-24
ER
PT J
AU Acartürk, TO
AF Acarturk, Tahsin Oguz
TI Reconstruction of lower extremity close-range shotgun injuries with
   gracilis free flap: a report of two cases
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Close range shotgun; gracilis free flap; lower extremity trauma
ID WOUND BALLISTICS; MUSCLE; DEFECTS
AB Close-range shotgun injury to the lower extremity is a devastating problem and is a challenge to the surgeon. Point-blank shotgun injuries to the extremities create a typical wound that is deep but not wide. These wounds almost always need to be treated with local or distant tissue transfer. We report two cases of shotgun injury to the lower extremity at point-blank range, which were treated using debridement, vacuum-assisted closure and free gracilis muscle flap transfer.
C1 Cukurova Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Adana, Turkey.
C3 Cukurova University
RP Acartürk, TO (通讯作者)，Cukurova Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, PK 1275 Gar, Adana, Turkey.
EM toacarturk@yahoo.com
RI Acarturk, Tahsin/MIT-6667-2025
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NR 11
TC 3
Z9 4
U1 0
U2 1
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD JUL
PY 2010
VL 16
IS 4
BP 367
EP 370
PG 4
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 636TI
UT WOS:000280763500016
PM 20849057
DA 2026-07-24
ER
PT J
AU Nelson, JA
   Kim, EM
   Serletti, JM
   Wu, LC
AF Nelson, Jonas A.
   Kim, Elizabeth M.
   Serletti, Joseph M.
   Wu, Liza C.
TI A Novel Technique for Lower Extremity Limb Salvage: The Vastus Lateralis
   Muscle Flap with Concurrent Use of the Vacuum-Assisted Closure Device
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE Cook Doppler; vastus lateralis; vacuum-assisted closure device
ID MICROVASCULAR FREE FLAPS; IMPLANTABLE DOPPLER; EXPERIENCE;
   RECONSTRUCTION; PROBE
AB Free tissue transfer is an essential component of lower extremity limb reconstruction and has dramatically improved salvage attempts. In this report, we examine the use of the underutilized free vastus lateralis muscle flap and describe our treatment protocol that involves a novel application for the vacuum-assisted closure device in an effort to reduce edema and congestion in lower extremity limb salvage. Thirteen patients underwent reconstruction with 14 vastus lateralis flaps with closure occurring on average 35.2 days after injury and an average case duration of 4:34 hours. We report one flap failure, one superficial abscess, and one donor site hematoma. All patients were ambulatory at 6 months. Our early experience using this underutilized flap and novel protocol demonstrate successful lower extremity reconstruction with few complications, and good function and contour. Given its advantages, this versatile flap should be included as an option in lower extremity limb salvage operations.
C1 [Nelson, Jonas A.; Kim, Elizabeth M.; Serletti, Joseph M.; Wu, Liza C.] Univ Penn, Sch Med, Div Plast Surg, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Wu, LC (通讯作者)，Univ Penn, Sch Med, Div Plast Surg, 10 Penn Tower,3400 Spruce St, Philadelphia, PA 19104 USA.
EM Liza.Wu@uphs.upenn.edu
OI Nelson, Jonas/0000-0003-0329-4422
FU Doris Duke Clinical Research Fellowship
FX This project was made possible in part by the Doris Duke Clinical
   Research Fellowship.
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NR 14
TC 13
Z9 14
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD SEP
PY 2010
VL 26
IS 7
BP 427
EP 431
DI 10.1055/s-0030-1251561
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 637GL
UT WOS:000280805300001
PM 20309803
DA 2026-07-24
ER
PT J
AU Arezzo, A
   Miegge, A
   Garbarini, A
   Morino, M
AF Arezzo, A.
   Miegge, A.
   Garbarini, A.
   Morino, M.
TI Endoluminal vacuum therapy for anastomotic leaks after rectal surgery
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE Endosponge; Surgical wound dehiscence; Negative pressure wound therapy;
   Vacuum-assisted closure
ID ASSISTED CLOSURE; WOUND CONTROL; EXPERIENCE
AB Anastomotic leakage after rectal surgery is a very serious complication and is the main cause of postoperative morbidity and mortality. We describe three cases of rectal leakage which we treated with endoscopic vacuum-assisted closure. We used the Endo-SPONGE (B. Braun Aesculap AG, Germany), which consists of an open-cell, cylindrical polyurethane sponge connected to a drainage tube which is linked to a vacuum system to exert constant suction. The possible role of this new tool in the management of anastomotic leaks is also discussed.
C1 [Arezzo, A.; Miegge, A.; Garbarini, A.; Morino, M.] Univ Turin, I-10126 Turin, Italy.
C3 University of Turin
RP Arezzo, A (通讯作者)，Univ Turin, Corso Dogliotti 14, I-10126 Turin, Italy.
EM alberto.arezzo@unito.it
RI Arezzo, Alberto/AAB-6552-2020; Morino, Mario/AAI-6437-2020
OI Arezzo, Alberto/0000-0002-2110-4082; Morino, Mario/0000-0003-4540-1409
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bemelman WA, 2009, TECH COLOPROCTOL, V13, P261, DOI 10.1007/s10151-009-0543-x
   D'Hondt M, 2009, TECH COLOPROCTOL, V13, P311, DOI 10.1007/s10151-009-0505-3
   Durai R, 2009, TECH COLOPROCTOL, V13, P307, DOI 10.1007/s10151-009-0503-5
   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   van Koperen PJ, 2009, SURG ENDOSC, V23, P1379, DOI 10.1007/s00464-008-0186-4
   Weidenhagen R, 2008, Rozhl Chir, V87, P397
NR 8
TC 41
Z9 45
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1123-6337
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD SEP
PY 2010
VL 14
IS 3
BP 279
EP 281
DI 10.1007/s10151-010-0569-0
PG 3
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 641XZ
UT WOS:000281167400015
PM 20352276
DA 2026-07-24
ER
PT J
AU Moiemen, NS
   Yarrow, J
   Kamel, D
   Kearns, D
   Mendonca, D
AF Moiemen, Naiem S.
   Yarrow, Jeremy
   Kamel, Dia
   Kearns, Daniel
   Mendonca, Derek
TI Topical negative pressure therapy: Does it accelerate neovascularisation
   within the dermal regeneration template, Integra? A prospective
   histological in vivo study
SO BURNS
LA English
DT Article
DE Integra; Topical negative pressure; Skin substitutes; Histology,
   Vascularisation; Dermal regeneration template
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; CHRONIC WOUNDS;
   SUBATMOSPHERIC PRESSURE; ANGIOGENESIS; DRESSINGS; MECHANISM; DEVICE;
   TRIAL
AB Background: The use of topical negative pressure (TNP) dressings with dermal regeneration template (DRT), Integra, has improved outcomes and simplified aftercare. Previous clinical studies have suggested accelerated vascularisation; with a reduction in the duration of the 1st stage after the application of Integra, from 2 to 4 weeks to as little as 4 days, but with no histological evidence. However, histological studies, without TNP, have shown that vascularisation occurs between the second and the fourth week. This study set out to examine histologically the rate of DRT neovascularisation when combined with TNP.
   Methods: Eight patients with nine reconstruction sites were enlisted. Unmeshed Integra and fibrin sealant to promote adherence were used. TNP was applied for the duration between the 1st and the 2nd stages. Patients underwent serial biopsies on days 7, 14, 21 and 28 post-application. The biopsies were stained with H&E and endothelial markers CD31 and CD34. Template vascularisation was assessed as a percentage of the template depth in which patent, canalised vascular channels could be demonstrated.
   Results: The median percentage of the template depth which demonstrated canalised channels was 0%, 20%, 61% and 80% for days, 7, 14, 21 and 28, respectively.
   Conclusion: The application of TNP dressings to dermal templates can reduce shearing forces, restrict seroma and haematoma formation, simplify wound care and improve patient tolerance. However, this study could not demonstrate that TNP accelerates neovascularisation as verified by the presence of histologically patent vascular channels. Crown Copyright (C) 2010 Published by Elsevier Ltd and ISBI. All rights reserved.
C1 [Moiemen, Naiem S.; Yarrow, Jeremy; Mendonca, Derek] Univ Hosp Birmingham NHS Fdn Trust, Midlands Burn Ctr, Birmingham, W Midlands, England.
   [Kamel, Dia; Kearns, Daniel] Univ Birmingham, Dept Histopathol, Birmingham, W Midlands, England.
C3 University of Birmingham; University of Birmingham
RP Moiemen, NS (通讯作者)，Univ Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Med Ctr, Birmingham, W Midlands, England.
EM nmoiemen@aol.com
OI Moiemen, Naiem/0000-0003-0836-5138; Mendonca, Derek
   Amith/0000-0002-7861-1966; Kearns, Daniel/0009-0005-3513-2112
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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   McEwan W, 2004, BURNS, V30, P259, DOI 10.1016/j.burns.2003.11.011
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   Molnar JA, 2004, PLAST RECONSTR SURG, V113, P1339, DOI 10.1097/01.PRS.0000112746.67050.68
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Potter MJ, 2008, BURNS, V34, P164, DOI 10.1016/j.burns.2007.06.020
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   STERN R, 1990, Journal of Burn Care and Rehabilitation, V11, P7, DOI 10.1097/00004630-199001000-00003
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
NR 18
TC 43
Z9 48
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
J9 BURNS
JI Burns
PD SEP
PY 2010
VL 36
IS 6
BP 764
EP 768
DI 10.1016/j.burns.2010.04.011
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 642CW
UT WOS:000281182100004
PM 20494522
DA 2026-07-24
ER
PT J
AU Mullally, C
   Carey, K
   Seshadri, R
AF Mullally, Colleen
   Carey, Kim
   Seshadri, Ravi
TI Use of a nanocrystalline silver dressing and vacuum-assisted closure in
   a severely burned dog
SO JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
LA English
DT Article
DE negative pressure wound therapy; silver dressings; thermal burns
ID TOPICAL NEGATIVE-PRESSURE; SUBATMOSPHERIC PRESSURE; SMOKE EXPOSURE;
   THERMAL BURNS; MANAGEMENT; THERAPY; WOUNDS; CATS
AB Objective - To describe the first veterinary use of a nanocrystalline silver dressing (NSD) and use of vacuum-assisted closure (VAC) to treat a severely burned dog.
   Case or Series Summary - A 1-year-old female intact American Staffordshire Terrier with 50% total body surface area burned was referred for definitive care approximately 18-24 hours post injury. The dog was treated with crystalloid fluids, hydroxyethyl starch, and antimicrobials based on culture and sensitivity results of wound cultures, fresh frozen plasma, human serum albumin, and packed red cells. Wound care initially consisted of daily debridement under anesthesia with silver sulfadiazine application and bandaging. Because of the extent and the location of the wounds and morbid state of the patient, early wound grafting was not an option. Because of its reported improvement in granulation tissue formation and decreased tissue edema, VAC was used once the majority of burned tissue was manually debrided. Because of the pain caused by VAC and traditional bandaging techniques with this extent of injury, an NSD was utilized. This strategy was chosen due to the antimicrobial properties of NSD and the reduced necessity for daily bandage changes, which was reduced to only every 3 days. This protocol reduced the need for daily sedation or anesthesia.
   New or Unique Information Provided - VAC and NSD were used successfully for the treatment of a severe burn injury in a dog. The use of NSD decreased the cost of therapy by reducing the need for daily bandage changes, thereby reducing the anesthetic and analgesic costs and allowing the patient to be managed on an outpatient basis.
C1 [Mullally, Colleen; Carey, Kim] City Angels Vet Specialty Ctr, Culver City, CA 90232 USA.
   [Seshadri, Ravi] Vet Specialty Ctr, Salt Lake City, UT 84106 USA.
RP Mullally, C (通讯作者)，City Angels Vet Specialty Ctr, 9599 Jefferson Blvd, Culver City, CA 90232 USA.
EM colleen_mullally@hotmail.com
CR APELQVIST J, 2008, INT WOUND J S4, V5, P19
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NR 32
TC 29
Z9 31
U1 0
U2 27
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1479-3261
J9 J VET EMERG CRIT CAR
JI J. Vet. Emerg. Crit. Care
PD AUG
PY 2010
VL 20
IS 4
BP 456
EP 463
DI 10.1111/j.1476-4431.2010.00564.x
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 642JF
UT WOS:000281207500013
PM 20731813
DA 2026-07-24
ER
PT J
AU Verhaalen, A
   Watkins, B
   Brasel, K
AF Verhaalen, Amy
   Watkins, Bruce
   Brasel, Karen
TI Techniques and Cost Effectiveness of Enteroatmospheric Fistula Isolation
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID MANAGEMENT
AB Background. The following describes successful isolation of enteroatmospheric fistulae within a negative pressure wound therapy system (V.A.C.(R), KCI, San Antonio, TX). Methods. An impermeable. tubular structure was placed around the fistula with a dressing applied to the surrounding wound base, dressed with an impermeable drape and negative pressure, and then an ostomy appliance was placed over the isolated fistula stoma. Cost analysis compared traditional dressings to the NPWT isolation method. Results. All patients underwent fistula isolation with complete diversion of enteric contents. Typical dressing changes occurred 3 times per week. Four patients were discharged from the hospital prior to surgical repair. Conclusion. Successful isolation of enteroatmospheric fistulae using a NPWT system has the potential to lower healthcare system costs by allowing for earlier hospital discharge.
C1 [Verhaalen, Amy; Watkins, Bruce; Brasel, Karen] Med Coll Wisconsin, Dept Gen Trauma & Crit Care Surg, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Verhaalen, A (通讯作者)，9200 W Wisconsin, Milwaukee, WI 53226 USA.
EM averhaal@mcw.edu
CR Edelmann G, 1979, Chirurgie, V105, P503
   Goverman J, 2006, J TRAUMA, V60, P428, DOI 10.1097/01.ta.0000203588.66012.c4
   Kordasiewicz Lynn M, 2004, J Wound Ostomy Continence Nurs, V31, P150
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   Wild T, 2007, Ther Umsch, V64, P495, DOI 10.1024/0040-5930.64.9.495
NR 7
TC 18
Z9 22
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2010
VL 22
IS 8
BP 212
EP 217
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 643LS
UT WOS:000281298600006
PM 25901513
DA 2026-07-24
ER
PT J
AU Paggiaro, AO
   de Carvalho, VF
   Fonseca, GHH
   Doi, A
   Ferreira, MC
AF Paggiaro, Andre Oliveira
   de Carvalho, Viviane Fernandes
   Fonseca, Guilherme Henrique Hencklain
   Doi, Allison
   Ferreira, Marcus Castro
TI Negative Pressure Therapy for Complex Wounds in Patients with
   Sickle-Cell Disease: A Case Study
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE sickle-cell anemia; lower leg ulcer; case study; wound healing; negative
   pressure wound therapy
ID LEG ULCERS
AB Sickle-cell disease is the most prevalent genetic disease in the Brazilian population. Lower limb ulcers are the most frequent cutaneous complications, affecting 8% to 10% of the patients. These ulcers are usually deep and may take many years to heal. Evidence about the effectiveness of systemic or topical treatment of these wounds is limited, apart from stabilization of the anemia. A 28-year old woman with sickle-cell disease was admitted for treatment of three deep chronic lower leg ulcers. All wounds had tendon exposure and contained firmly adherent fibrin slough. Following surgical debridement and before grafting, the wounds were managed with three different dressings: a rayon and normal saline solution dressing, a calcium alginate dressing covered with gauze, and negative pressure therapy. All three wounds healed successfully and their grafts showed complete integration; only the rayon-dressed wound required a second debridement. The alginate and rayon-dressed wounds recurred after 9 months and required additional skin grafts. Helpful research on managing ulcers in patients with sickle-cell disease is minimal, but the results of this case study suggest that topical treatment modalities may affect outcomes. Research to explore the safety and effectiveness of NPT in patients with sickle-cell wounds is warranted.
C1 [Ferreira, Marcus Castro] Univ Sao Paulo, Fac Med, Hosp Clin, Div Plast Surg, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP de Carvalho, VF (通讯作者)，Av Dr Arnaldo,455 Room 1363, BR-01246903 Sao Paulo, Brazil.
EM vivianefcarvalho@usp.br
RI Paggiaro, Andr�/F-1570-2016; Carvalho, Viviane/H-9511-2013
OI Carvalho, Viviane/0000-0002-0807-0586
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 17
TC 11
Z9 11
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD AUG
PY 2010
VL 56
IS 8
BP 62
EP 67
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 644CO
UT WOS:000281348300013
PM 20729564
DA 2026-07-24
ER
PT J
AU Schmelzle, M
   Alldinger, I
   Matthaei, H
   Aydin, F
   Wallert, I
   Eisenberger, CF
   Esch, JSA
   Dizdar, L
   Topp, SA
   Yang, Q
   Knoefel, WT
AF Schmelzle, Moritz
   Alldinger, Ingo
   Matthaei, Hanno
   Aydin, Feride
   Wallert, Ingo
   Eisenberger, Claus F.
   Esch, Jan Schulte Am, II
   Dizdar, Levent
   Topp, Stefan A.
   Yang, Qin
   Knoefel, Wolfram T.
TI Long-Term Vacuum-Assisted Closure in Open Abdomen due to Secondary
   Peritonitis: A Retrospective Evaluation of a Selected Group of Patients
SO DIGESTIVE SURGERY
LA English
DT Article
DE Vacuum-assisted closure therapy; Open abdomen; Peritonitis
ID FASCIAL CLOSURE; ENTEROCUTANEOUS FISTULA; ABDOMINAL CLOSURE; VENTRAL
   HERNIA; WOUND CLOSURE; TRAUMA; EXPERIENCE; MANAGEMENT
AB Background/Aims: Vacuum-assisted closure (VAC) leads to a high fascial closure rate in open abdomen within the first week of treatment. However, little data exist on the role of long-term VAC treatment in patients with peritonitis, where fascial closure cannot be accomplished within the first days. Methods: We reviewed the medical records of 49 patients with open abdomen for more than 7 days due to secondary peritonitis, who underwent a VAC-treatment. Nonparametric analysis was performed using chi(2) test or Fisher's exact test. Results: Fascial closure could be accomplished in only 11 patients (22%), whereas complications occurred in 43 patients (88%). Re-explorations after starting VAC were associated with the occurrence of enterocutaneous fistula (p < 0.001) and were also of prognostic value regarding the rate of fascial closure (p = 0.033). Conclusions: If fascial closure cannot be accomplished within the first days, patients show a dramatically lower fascial closure and an increased complication rate with VAC. Further studies are needed to evaluate whether this subgroup really benefits from VAC. Copyright (C) 2010 S. Karger AG, Basel
C1 [Schmelzle, Moritz; Alldinger, Ingo; Matthaei, Hanno; Aydin, Feride; Wallert, Ingo; Eisenberger, Claus F.; Esch, Jan Schulte Am, II; Dizdar, Levent; Topp, Stefan A.; Knoefel, Wolfram T.] Univ Hosp Dusseldorf, Dept Surg, DE-40225 Dusseldorf, Germany.
   [Yang, Qin] Univ Dusseldorf, Fac Med, Coordinat Ctr Clin Trials, Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf Hospital; Heinrich Heine University Dusseldorf
RP Knoefel, WT (通讯作者)，Univ Hosp Dusseldorf, Dept Surg, Moorenstr 5, DE-40225 Dusseldorf, Germany.
EM knoefel@med.uni-duesseldorf.de
RI Esch, Jan/AAL-9904-2021
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   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
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NR 21
TC 27
Z9 34
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0253-4886
EI 1421-9883
J9 DIGEST SURG
JI Dig. Surg.
PY 2010
VL 27
IS 4
BP 272
EP 278
DI 10.1159/000314609
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 646DT
UT WOS:000281517500005
PM 20664203
DA 2026-07-24
ER
PT J
AU Wu, SC
   Marston, W
   Armstrong, DG
AF Wu, Stephanie C.
   Marston, William
   Armstrong, David G.
TI Wound care: The role of advanced wound healing technologies
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID DIABETIC FOOT ULCERS; HYPERBARIC-OXYGEN THERAPY;
   RANDOMIZED-CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY
   ULCERS; HUMAN SKIN EQUIVALENT; MARROW-DERIVED CELLS; COST-EFFECTIVENESS;
   MULTICENTER; CULTURE
AB Wound repair and regeneration is a highly complex combination of matrix destruction and reorganization. While major hurdles remain, advances over the past generation have improved the clinician's armamentarium in the medical and surgical management of this problem. The purpose of this manuscript is to review the current literature regarding the pragmatic use of three of the most commonly employed advanced therapies; namely, bioengineered tissue, negative pressure wound therapy, and hyperbaric oxygen therapy with a focus on the near-term future of wound healing, including stem cell therapy. (J Vase Surg 2010;52:59S-66S.)
C1 [Armstrong, David G.] Univ Arizona, Coll Med, Dept Surg, SALSA, Tucson, AZ 85724 USA.
   [Wu, Stephanie C.] Rosalind Franklin Univ Med & Sci, N Chicago, IL USA.
   [Marston, William] Univ N Carolina, Sch Med, Dept Surg, Vasc Surg Sect, Chapel Hill, NC USA.
C3 University of Arizona; Rosalind Franklin University of Medicine &
   Science; University of North Carolina; University of North Carolina
   Chapel Hill; University of North Carolina School of Medicine
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, Dept Surg, SALSA, Tucson, AZ 85724 USA.
EM armstrong@usa.net
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NR 56
TC 48
Z9 62
U1 0
U2 20
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD SEP
PY 2010
VL 52
SU S
BP 59S
EP 66S
DI 10.1016/j.jvs.2010.06.009
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 646VC
UT WOS:000281570200009
PM 20804934
DA 2026-07-24
ER
PT J
AU Waibel, BH
   Rotondo, MF
AF Waibel, Brett H.
   Rotondo, Michael F.
TI Damage control in trauma and abdominal sepsis
SO CRITICAL CARE MEDICINE
LA English
DT Article
DE damage control; resuscitation; abdominal wounds; sepsis; trauma
ID VACUUM-ASSISTED CLOSURE; RECOMBINANT-FACTOR-VIIA; RED-BLOOD-CELLS;
   INTENSIVE INSULIN THERAPY; ACELLULAR DERMAL MATRIX; MULTIPLE ORGAN
   FAILURE; FRESH-FROZEN PLASMA; OPEN ABDOMEN; COMPARTMENT SYNDROME; FLUID
   RESUSCITATION
AB Damage control surgery, initially formalized <20 yrs ago, was developed to overcome the poor outcomes in exsanguinating abdominal trauma with traditional surgical approaches. The core concepts for damage control of hemorrhage and contamination control with abbreviated laparotomy followed by resuscitation before definitive repair, although simple in nature, have led to an alteration in which emergent surgery is handled among a multitude of problems, including abdominal sepsis and battlefield surgery. With the aggressive resuscitation associated with damage control surgery, understanding of abdominal compartment syndrome has expanded. It is probably through avoiding this clinical entity that the greatest improvement in surgical outcomes for various emergent surgical problems has occurred in the past two decades. However, with its success, new problems have emerged, including increases in enterocutaneous fistulas and open abdomens. But as with any crisis, innovative strategies are being developed. New approaches to control of the open abdomen and reconstruction of the abdominal wall are being developed from negative pressure dressing therapies to acellular allograft meshes. With further understanding of new resuscitative strategies, the need for damage control surgery may decline, along with its concomitant complications, at the same time retaining the success that damage control surgery has brought to the critically ill trauma and general surgery patient in the past few years. (Crit Care Med 2010; 38[Suppl.]:S421-S430)
C1 [Waibel, Brett H.; Rotondo, Michael F.] E Carolina Univ, Dept Surg, Brody Sch Med, Div Trauma & Surg Crit Care, Greenville, NC 27858 USA.
C3 University of North Carolina; East Carolina University
RP Waibel, BH (通讯作者)，E Carolina Univ, Dept Surg, Brody Sch Med, Div Trauma & Surg Crit Care, Greenville, NC 27858 USA.
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   STONE HH, 1983, ANN SURG, V197, P532, DOI 10.1097/00000658-198305000-00005
   Subramaniam MH, 2002, J TRAUMA, V53, P386, DOI 10.1097/00005373-200208000-00037
   Teixeira PGR, 2009, J TRAUMA, V66, P693, DOI 10.1097/TA.0b013e31817e5c77
   Tisherman SA, 2004, J TRAUMA, V57, P898, DOI 10.1097/01.TA.0000133577.25793.E5
   Tremblay LN, 2001, AM J SURG, V182, P670, DOI 10.1016/S0002-9610(01)00805-4
   Tsuei BJ, 2004, AM SURGEON, V70, P652
   Van den Berghe G, 2001, NEW ENGL J MED, V345, P1359, DOI 10.1056/NEJMoa011300
   Vargo D, 2009, AM SURGEON, V75, pS1
   Vertrees A, 2008, J AM COLL SURGEONS, V207, P801, DOI 10.1016/j.jamcollsurg.2008.08.014
   Waibel BH, 2010, PEDIATR CRIT CARE ME, V11, P199, DOI 10.1097/PCC.0b013e3181b80500
   Waibel BH, 2009, J AM COLL SURGEONS, V209, P580, DOI 10.1016/j.jamcollsurg.2009.07.021
   Wang HE, 2005, CRIT CARE MED, V33, P1296, DOI 10.1097/01.CCM.0000165965.31895.80
   Watters JM, 2006, J TRAUMA, V61, P300, DOI 10.1097/01.ta.0000224211.36154.44
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NR 169
TC 60
Z9 71
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD SEP
PY 2010
VL 38
IS 9
SU S
BP S421
EP S430
DI 10.1097/CCM.0b013e3181ec5cbe
PG 10
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 647FB
UT WOS:000281602100003
PM 20724875
DA 2026-07-24
ER
PT J
AU Lalliss, SJ
   Stinner, DJ
   Waterman, SM
   Branstetter, JG
   Masini, BD
   Wenke, JC
AF Lalliss, Steven J.
   Stinner, Daniel J.
   Waterman, Scott M.
   Branstetter, Joanna G.
   Masini, Brendan D.
   Wenke, Joseph C.
TI Negative Pressure Wound Therapy Reduces Pseudomonas Wound
   Contamination More Than Staphylococcus aureus
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE contamination; infection; open fracture; trauma; negative pressure;
   wound management; acute care
ID VACUUM-ASSISTED CLOSURE
AB Purpose: The purpose of this study is to determine if negative pressure wound therapy (NPWT) treatment results in fewer bacteria than wet-to-dry., (WTD) dressings in a contaminated open fracture wound model
   Methods: For Study Study I. complex wounds were created on the proximal left leg of goats The wounds were inoculated with Pseudomonas aeruginosa The wounds were debrided and irrigated 6 hours after inoculation The first group received WTD dressing chanties twice daily, the second and third groups received NPWT using systems from two different companies All three groups received repeat debridements every 48 hours for 6 days Bacteria quantification was performed both immediately before and after each dabridement For Study 2, the only changes were that Staphylococcus aureus was used and only one NPWT group was included
   Results: In Study I. there were significantly fewer Pseudomonas in both NPWT groups at all imaging sessions after the initial dabridement and irrigation At the 6-day time point. the wounds in the NPWT groups were 43 +/- 14% and 68 +/- 6% of the baseline amount, respectively The WTD groups were 464 +/- 102% of the baseline amount In Study 2, NPWT did not reduce the S aureus contamination within the wound At the 6-day time point, the wounds in the NPWT and WTD groups contained 115 +/- 19% and 192 +/- 52% of the baseline values. respectively
   Conclusion: NPWT showed a significant and sustained decrease in the Pseudomonas levels compared with WTD dressings at all time points This beneficial effect was seen not seen in S aureus
C1 [Lalliss, Steven J.; Stinner, Daniel J.; Waterman, Scott M.; Branstetter, Joanna G.; Masini, Brendan D.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Wenke, JC (通讯作者)，USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
RI Stinner, Daniel/KSM-9513-2024
OI Stinner, Daniel/0000-0002-8981-6262
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   BODEY GP, 1983, REV INFECT DIS, V5, P279
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Dedmond BT, 2007, J ORTHOP TRAUMA, V21, P11, DOI 10.1097/BOT.0b013e31802cbc54
   Herscovici D, 2003, J ORTHOP TRAUMA, V17, P683, DOI 10.1097/00005131-200311000-00004
   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
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NR 15
TC 91
Z9 103
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2010
VL 24
IS 9
BP 598
EP 602
DI 10.1097/BOT.0b013e3181ec45ba
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 647FL
UT WOS:000281603100018
PM 20736802
DA 2026-07-24
ER
PT J
AU Arnold-Long, M
   Johnson, R
   Reed, L
AF Arnold-Long, Mary
   Johnson, Richard
   Reed, LuAnn
TI Negative Pressure Wound Therapy Overlay Technique With Collagen
   Dressings for Nonhealing Wounds
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
AB BACKGROUND: Our clinical experience suggests that the effectiveness of negative pressure wound therapy is enhanced by adding collagen alginate to the dressing regimen, applying foam over areas that are undermined or tunneled, and approximating and securing wound edges prior to applying foam.
   CASES: The use of this combined technique is described in 4 cases, including 2 patients with spinal cord injury and category IV pressure ulcers and 2 patients with extensive postsurgical wounds.
   CONCLUSION: Our outcomes demonstrate the feasibility of this technique and suggest that patients with significant wound size benefit from adding collagen alginate to negative pressure wound therapy and by applying foam over areas that are undermined or tunneled and/or approximating and securing wound edges prior to applying foam.
C1 [Arnold-Long, Mary] Drake Ctr, Cincinnati, OH 45216 USA.
RP Arnold-Long, M (通讯作者)，Drake Ctr, 151 W Galbraith Rd, Cincinnati, OH 45216 USA.
EM mary.long@healthall.com
CR Brett D, 2008, WOUNDS, V20, P347
   FLECK CA, 2004, EXTENDED CARE PRODUC, V92, P20
   *OFF INSP GEN, 2009, PUBL OFF INSP GEN
NR 3
TC 4
Z9 4
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1071-5754
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2010
VL 37
IS 5
BP 549
EP 553
DI 10.1097/WON.0b013e3181eda751
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 649JG
UT WOS:000281764300016
PM 20838320
DA 2026-07-24
ER
PT J
AU Hutan, M
   Sen, HM
AF Hutan, M., Jr.
   Sen, Hutan M.
TI Sandwich Mesh Abdominal Closure
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE SMAC; VAC; open abdomen
ID VACUUM-ASSISTED CLOSURE
AB The open abdomen carries a high mortality rate and represents a big surgical challenge. The recent introduction of vacuum assisted closure (VAC) introduced new techniques of its management, including STAR - Staged Abdominal Repair, Fabian Protocol, VAC supported with PDS, support with polyglactin mesh and the use of tissue expanders in the staged closure of the open abdomen. One of the methods, SMAC - sandwich mesh abdominal closure, emerged in April 2008 by the clinical group from Germany.
   The authors present their own modification of SMAC and a case report, where it was used. By current literary research it was the first patient in the Central European hospital managed by SMAC VAC.
   The authors of the article conclude that SMAC VAC and its modification is highly effective in the management of the open abdomen (Fig. 5, Ref. 4). Full Text in free PDF www.bmj.sk.
C1 [Hutan, M., Jr.; Sen, Hutan M.] Comenius Univ, Dept Surg 4, Fac Med, SK-85197 Bratislava, Slovakia.
C3 Comenius University Bratislava
RP Hutan, M (通讯作者)，Comenius Univ, Dept Surg 4, Fac Med, Antolska 11, SK-85197 Bratislava, Slovakia.
EM matohuto@yahoo.com
CR Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Perez D, 2007, J AM COLL SURGEONS, V205, P586, DOI 10.1016/j.jamcollsurg.2007.05.015
   WIDMAIER U, 2008, VAC DREI LAND K APR
   Zingales F, 2001, Chir Ital, V53, P821
NR 4
TC 2
Z9 2
U1 0
U2 0
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2010
VL 111
IS 8
BP 461
EP 463
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 649NK
UT WOS:000281778100009
PM 21033628
DA 2026-07-24
ER
PT J
AU Sarkar, B
   Napolitano, LM
AF Sarkar, B.
   Napolitano, L. M.
TI Necrotizing soft tissue infections
SO MINERVA CHIRURGICA
LA English
DT Review
DE Soft tissue infections; Fasciitis, necrotizing; Gas gangrene
ID RESISTANT STAPHYLOCOCCUS-AUREUS; COMPLICATED INTRAABDOMINAL INFECTION;
   LABORATORY RISK INDICATOR; HYPERBARIC-OXYGEN THERAPY;
   TOXIC-SHOCK-SYNDROME; VIBRIO-VULNIFICUS; EMERGENCY-DEPARTMENT; CHILDREN
   GUIDELINES; FOURNIERS GANGRENE; DISEASES SOCIETY
AB Necrotizing soft tissue infections (NSTIs) are aggressive severe soft tissue infection that cause rapid and widespread infection and necrosis of the skin and soft tissues and are highly lethal. NSTIs include necrotizing cellulitis, adipositis, fasciitis and myositis/myonecrosis and have significant potential for extensive soft tissue and limb loss. Early diagnosis and treatment of NSTIs remains the cornerstone of therapy. Timely aggressive surgical debridement and early appropriate antibiotic treatment are required for a successful outcome and clinical cure. Mortality rate has decreased from 25-50% in past years, to 10-16% in recent years with aggressive surgical and medical management. Additional innovative strategies for the treatment of NSTIs, including intravenous immuno-globulin G (WIG), hyperbaric oxygen, and vacuum-assisted closure, do not yet have definitive evidence of efficacy, but may be considered in patients at high risk of death. A comprehensive knowledge of the pathophysiology, diagnostic features, causative microbial pathogens, and treatment strategies (including surgical debridement and antimicrobial therapy) is required for successful management of NSTIs.
C1 [Sarkar, B.; Napolitano, L. M.] Univ Michigan, Dept Surg, Div Acute Care Surg, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Napolitano, LM (通讯作者)，Univ Michigan Hlth Syst, Dept Surg, Room 1C421 Univ Hosp,1500 E Med Dr, Ann Arbor, MI 48109 USA.
EM lenan@umich.edu
RI Napolitano, Lena/AAZ-8651-2021
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NR 102
TC 12
Z9 12
U1 0
U2 9
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4733
EI 1827-1626
J9 MINERVA CHIR
JI Minerva Chir.
PD JUN
PY 2010
VL 65
IS 3
BP 347
EP 362
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 654JG
UT WOS:000282163700010
PM 20668422
DA 2026-07-24
ER
PT J
AU Heap, S
   Mehra, S
   Tavakoli, A
   Augustine, T
   Riad, H
   Pararajasingam, R
AF Heap, Sarah
   Mehra, Sanjay
   Tavakoli, Afshin
   Augustine, Titus
   Riad, Hany
   Pararajasingam, Ravi
TI Negative Pressure Wound Therapy Used to Heal Complex Urinary Fistula
   Wounds Following Renal Transplantation into an Ileal Conduit
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Article
DE Ileal conduit; negative pressure wound therapy; renal transplantation;
   urinary fistula
ID KIDNEY-TRANSPLANTATION
AB Transplantation into an ileal conduit is an established option for patients with end-stage renal failure and a nonfunctioning urinary tract. Urinary fistulae are more common following these complex transplants. Urinary fistula in this scenario can cause substantial morbidity and even result in graft loss. The management options depend on the viability of the transplant ureter, the level of local sepsis and the overall condition of the patient. Urinary diversion with a nephrostomy and ureteric stents has been described in aiding the healing of urinary leaks in renal transplants into a functioning urinary tract. We describe the successful use of negative wound pressure therapy to eradicate the local sepsis and help the healing of a recurrent urinary fistula following kidney transplantation into an ileal conduit. To our knowledge these are the first such cases reported in the literature.
C1 [Heap, Sarah; Mehra, Sanjay; Tavakoli, Afshin; Augustine, Titus; Riad, Hany; Pararajasingam, Ravi] Cent Manchester Univ Hosp, Transplant Unit, Manchester Royal Infirm, Manchester, Lancs, England.
C3 University of Manchester
RP Heap, S (通讯作者)，Cent Manchester Univ Hosp, Transplant Unit, Manchester Royal Infirm, Manchester, Lancs, England.
EM sarahheap@hotmail.co.uk
RI Mehra, Sanjay/MSZ-6822-2025; Augustine, Titus/H-8729-2019
OI Augustine, Titus/0000-0002-7391-1839
CR Nie ZL, 2009, TRANSPL P, V41, P1624, DOI 10.1016/j.transproceed.2008.10.103
   SHESTHA B, 2007, KHATMANDU U MED J, V5, P4
   Stevens P, 2009, INT WOUND J, V6, P259, DOI 10.1111/j.1742-481X.2009.00614.x
   Surange RS, 2003, J UROLOGY, V170, P1727, DOI 10.1097/01.ju.0000092023.39043.67
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
   Vikatmaa P, 2008, EUR J VASC ENDOVASC, V36, P438, DOI 10.1016/j.ejvs.2008.06.010
NR 6
TC 7
Z9 10
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1600-6135
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD OCT
PY 2010
VL 10
IS 10
BP 2370
EP 2373
DI 10.1111/j.1600-6143.2010.03237.x
PG 4
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA 655CN
UT WOS:000282220400027
PM 20738265
OA Green Submitted, Green Published
DA 2026-07-24
ER
PT J
AU Garas, G
   Ifeacho, S
   Millard, R
   Tolley, N
AF Garas, G.
   Ifeacho, S.
   Millard, R.
   Tolley, N.
TI Melioidosis and the vacuum-assisted closure device: a rare cause of a
   discharging neck wound, and a new approach to management
SO JOURNAL OF LARYNGOLOGY AND OTOLOGY
LA English
DT Article
DE Melioidosis; Burkholderia Pseudomallei; Vacuum Pump
ID BURKHOLDERIA-PSEUDOMALLEI; STERNAL WOUNDS; AUSTRALIA; SYSTEM;
   EPIDEMIOLOGY; HEAD; MASS
AB Objective: We report a case of melioidosis presenting as a discharging neck abscess, and we describe the use of a vacuum-assisted closure device in its management.
   Method: We report the case of a 44-year-old, Afro-Caribbean woman with melioidosis. We also present the results of a literature search using the search terms 'melioidosis', 'Burkholderia pseudomallei' and 'vacuum-assisted closure device'.
   Results: Microbiological analysis identified the causative organism as being the bacterium Burkholderia pseudomallei, and its antimicrobial sensitivities to imipenem and ciprofloxacin. A vacuum-assisted closure device was used to manage the patient's melioidosis of the neck; we believe this is the first report of such treatment.
   Conclusions: Melioidosis is rare in the UK and western world; however, exposure can occur during travel to endemic areas. We therefore draw attention to this infection as part of the differential diagnosis of a neck abscess. We propose the use of vacuum-assisted closure devices as useful adjuncts to the management of discharging neck wounds.
C1 [Garas, G.; Ifeacho, S.; Millard, R.; Tolley, N.] St Marys Hosp, Dept Otorhinolaryngol Head & Neck Surg, London W2 1NY, England.
C3 Imperial College London
RP Garas, G (通讯作者)，St Marys Hosp, Dept Otorhinolaryngol Head & Neck Surg, Praed St, London W2 1NY, England.
EM garas_george@yahoo.com
RI Garas, George/AAC-1968-2019
OI Garas, George/0000-0001-7468-3287
CR Aldhous P, 2005, NATURE, V434, P692, DOI 10.1038/434692a
   Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Borgherini G, 2006, J TRAVEL MED, V13, P318, DOI 10.1111/j.1708-8305.2006.00050.x
   Chan KPW, 2005, CHEST, V128, P3674, DOI 10.1378/chest.128.5.3674
   Cheng AC, 2005, CLIN MICROBIOL REV, V18, P383, DOI 10.1128/CMR.18.2.383-416.2005
   Currie BJ, 2008, T ROY SOC TROP MED H, V102, P225, DOI 10.1016/j.trstmh.2007.11.005
   Currie BJ, 2000, CLIN INFECT DIS, V31, P981, DOI 10.1086/318116
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   Gibney KB, 2008, CLIN INFECT DIS, V47, P603, DOI 10.1086/590931
   Harlan JW, 2002, PLAST RECONSTR SURG, V109, P710, DOI 10.1097/00006534-200202000-00045
   Heng Bee Hoon, 1998, Annals Academy of Medicine Singapore, V27, P478
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   Kumar GSS, 2008, J NEUROSURG, V108, P243, DOI 10.3171/JNS/2008/108/2/0243
   Ma TL, 2008, JPN J INFECT DIS, V61, P151
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   Raja NS, 2008, J MICROBIOL IMMUNOL, V41, P174
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NR 32
TC 8
Z9 9
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0022-2151
EI 1748-5460
J9 J LARYNGOL OTOL
JI J. Laryngol. Otol.
PD SEP
PY 2010
VL 124
IS 9
BP 1021
EP 1024
DI 10.1017/S0022215110000381
PG 4
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 655GV
UT WOS:000282237900018
PM 20219147
DA 2026-07-24
ER
PT J
AU Riss, S
   Stift, A
   Kienbacher, C
   Dauser, B
   Haunold, I
   Kriwanek, S
   Radlsboek, W
   Bergmann, M
AF Riss, Stefan
   Stift, Anton
   Kienbacher, Caroline
   Dauser, Bernhard
   Haunold, Ingrid
   Kriwanek, Stefan
   Radlsboek, Wolfgang
   Bergmann, Michael
TI Recurrent abscess after primary successful endo-sponge treatment of
   anastomotic leakage following rectal surgery
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Rectal surgery; Anastomotic leakage; Endo-sponge; Endo-vacuum treatment
ID VACUUM-ASSISTED CLOSURE; COLORECTAL-CANCER; CURATIVE RESECTION; ANTERIOR
   RESECTION; LOCAL RECURRENCE; SURVIVAL; IMPACT; COMPLICATIONS; THERAPY;
   ETVARD
AB AIM: To assess long-term efficacy of initially successful endo-sponge assisted therapy.
   METHODS: Between 2006 and 2009, consecutive patients who had undergone primary successful endosponge treatment of anastomotic leakage following rectal cancer surgery were enrolled in the study. Patients were recruited from 6 surgical departments in Vienna. Clinical and oncologic outcomes were assessed through routine endoscopic and radiologic follow-up examination.
   RESULTS: Twenty patients (7 female, 13 male) were included. The indications for endo-sponge treatment were anastomotic leakage (n = 17) and insufficiency of a rectal stump after Hartmann's procedure (n = 3). All patients were primarily operated for rectal cancer. The overall mortality rate was 25%. The median follow-up duration was 17 mo (range 1.5-29.8 mo). Five patients (25%) developed a recurrent abscess. Median time between last day of endo-sponge therapy and occurrence of recurrent abscess was 255 d (range 21-733 d). One of these patients was treated by computed tomography-guided drainage and in 3 patients Hartmann's procedure had to be performed. Two patients (10%) developed a local tumor recurrence and subsequently died.
   CONCLUSION: Despite successful primary outcome, patients who receive endo-sponge therapy should be closely monitored in the first 2 years, since recurrence might occur. (C) 2010 Baishideng. All rights reserved.
C1 [Riss, Stefan; Stift, Anton; Bergmann, Michael] Med Univ Vienna, Div Gen Surg, Dept Surg, A-1090 Vienna, Austria.
   [Kienbacher, Caroline] Floridsdorf Hosp, Dept Surg, A-1210 Vienna, Austria.
   [Dauser, Bernhard] Barmherzige Bruder Wien, Dept Surg, A-1020 Vienna, Austria.
   [Haunold, Ingrid] Barmherzige Schwestern Wien, Dept Surg, A-1060 Vienna, Austria.
   [Kriwanek, Stefan] Rudolfstiftung Hosp, Dept Surg, A-1030 Vienna, Austria.
   [Radlsboek, Wolfgang] Gottlicher Heiland Wien, Dept Surg, A-1170 Vienna, Austria.
C3 Medical University of Vienna; Konventhospital Der Barmherzigen Bruder;
   Rudolfstiftung Hospital
RP Riss, S (通讯作者)，Med Univ Vienna, Div Gen Surg, Dept Surg, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM stefan.riss@meduniwien.ac.at
RI Bergmann, Michael/GZK-7700-2022
OI Bergmann, Michael/0000-0001-8529-1166; Stift, Anton/0000-0002-7243-8138
CR August DA, 2008, J SURG ONCOL, V97, P180, DOI 10.1002/jso.20938
   Bell SW, 2003, BRIT J SURG, V90, P1261, DOI 10.1002/bjs.4219
   den Dulk M, 2009, BRIT J SURG, V96, P1066, DOI 10.1002/bjs.6694
   Glitsch A, 2008, ENDOSCOPY, V40, P192, DOI 10.1055/s-2007-995384
   Jech B, 2007, EUR SURG, V39, P8, DOI 10.1007/s10353-007-0312-x
   Jorgren F., 2009, Colorectal Dis
   Jung SH, 2008, DIS COLON RECTUM, V51, P902, DOI 10.1007/s10350-008-9272-x
   Khan AA, 2008, COLORECTAL DIS, V10, P587, DOI 10.1111/j.1463-1318.2007.01417.x
   McArdle CS, 2005, BJS-BRIT J SURG, V92, P1150, DOI 10.1002/bjs.5054
   McMillan DC, 2003, BRIT J SURG, V90, P215, DOI 10.1002/bjs.4038
   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
   Nagell CF, 2006, INT J COLORECTAL DIS, V21, P657, DOI 10.1007/s00384-005-0083-4
   Nesbakken A, 2001, BRIT J SURG, V88, P400, DOI 10.1046/j.1365-2168.2001.01719.x
   Nielsen HJ, 2000, ANN SURG ONCOL, V7, P617, DOI 10.1007/BF02725342
   Petersen S, 1998, INT J COLORECTAL DIS, V13, P160, DOI 10.1007/s003840050158
   Rahbari NN, 2010, SURGERY, V147, P339, DOI 10.1016/j.surg.2009.10.012
   Riss S, 2010, COLORECTAL DIS, V12, pE104, DOI 10.1111/j.1463-1318.2009.01885.x
   Schintler MV, 2008, EUR SURG, V40, P11, DOI 10.1007/s10353-008-0381-5
   Van Koperen PJ, 2008, COLORECTAL DIS, V10, P943, DOI 10.1111/j.1463-1318.2008.01485.x
   van Koperen PJ, 2009, SURG ENDOSC, V23, P1379, DOI 10.1007/s00464-008-0186-4
   von Bernstorff W, 2009, INT J COLORECTAL DIS, V24, P819, DOI 10.1007/s00384-009-0673-7
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 22
TC 36
Z9 37
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD SEP 28
PY 2010
VL 16
IS 36
BP 4570
EP 4574
DI 10.3748/wjg.v16.i36.4570
PG 5
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 655PG
UT WOS:000282261300011
PM 20857528
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Popov, AF
   Schmitto, JD
   Tirilomis, T
   Bireta, C
   Coskun, KO
   Mokashi, SA
   Emmert, A
   Friedrich, M
   Wiese, CH
   Schoendube, FA
AF Popov, Aron F.
   Schmitto, Jan D.
   Tirilomis, Theodor
   Bireta, Christian
   Coskun, Kasim O.
   Mokashi, Suyog A.
   Emmert, Alexander
   Friedrich, Martin
   Wiese, Christoph H.
   Schoendube, Friedrich A.
TI Daptomycin as a possible new treatment option for surgical management of
   Methicillin-Resistant Staphylococcus aureus sternal wound infection
   after cardiac surgery
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID ARTERY-BYPASS GRAFT; COMPLICATED SKIN; MEDIASTINITIS; MICROBIOLOGY;
   ENDOCARDITIS; BACTEREMIA; VANCOMYCIN; THERAPY; CLOSURE; STAY
AB We present a case of a 77-year old female who had undergone a coronary artery bypass grafting with an aortic valve replacement and developed three month later a Methicillin-Resistant Staphylococcus aureus (MRSA) sternal wound infection which was successful treated with Daptomycin combined with vacuum-assisted closure (VAC).
C1 [Popov, Aron F.; Schmitto, Jan D.; Tirilomis, Theodor; Bireta, Christian; Coskun, Kasim O.; Emmert, Alexander; Friedrich, Martin; Schoendube, Friedrich A.] Univ Gottingen, Dept Thorac & Cardiovasc Surg, D-3400 Gottingen, Germany.
   [Schmitto, Jan D.; Mokashi, Suyog A.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Cardiac Surg,Dept Surg, Boston, MA USA.
   [Wiese, Christoph H.] Univ Gottingen, Dept Anaesthesiol Emergency & Intens Care Med, D-3400 Gottingen, Germany.
C3 University of Gottingen; Harvard University; Harvard Medical School;
   Harvard University Medical Affiliates; Brigham & Women's Hospital;
   University of Gottingen
RP Popov, AF (通讯作者)，Univ Gottingen, Dept Thorac & Cardiovasc Surg, D-3400 Gottingen, Germany.
EM Popov@med.uni-goettingen.de
RI Popov, Aron-Frederik/AAA-9933-2020; Friedrich, Martin/ONJ-5248-2025;
   Schmitto, Jan/AAC-6811-2020; Tirilomis, Theodor/AEP-0737-2022
OI Schmitto, Jan/0000-0002-0344-1405; 
FU Department of Thoracic Cardiovascular Surgery, University of Gottingen,
   Germany
FX The project was supported by a grant from the Department of Thoracic
   Cardiovascular Surgery, University of Gottingen, Germany. The authors
   gratefully thank Mrs. D. Sitte for her expert assistance at wound
   treatment.
CR Fowler VG, 2006, NEW ENGL J MED, V355, P653, DOI 10.1056/NEJMoa053783
   Fowler VG, 2003, CIRCULATION, V108, P73, DOI 10.1161/01.CIR.0000079105.65762.DB
   Furuya EY, 2003, CURR OPIN PHARMACOL, V3, P464, DOI 10.1016/j.coph.2003.05.004
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   NNIS System, 2002, AM J INFECT CONTROL, V30, P458, DOI 10.1067/mic.2002.130032
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   Weis F, 2007, ANN THORAC SURG, V84, P269, DOI 10.1016/j.athoracsur.2007.02.001
NR 17
TC 6
Z9 7
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD AUG 6
PY 2010
VL 5
AR 57
DI 10.1186/1749-8090-5-57
PG 3
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 656ME
UT WOS:000282338800001
PM 20691034
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lerman, B
   Oldenbrook, L
   Eichstadt, SL
   Ryu, J
   Fong, KD
   Schubart, PJ
AF Lerman, Bruce
   Oldenbrook, Leslie
   Eichstadt, Shaundra L.
   Ryu, Justin
   Fong, Kenton D.
   Schubart, Peter J.
TI Evaluation of Chronic Wound Treatment with the SNaP Wound Care System
   versus Modern Dressing Protocols
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; THERAPY; STATE
AB Background: Traditional negative-pressure wound therapy systems use an electrically powered pump to generate negative pressure at the wound bed. The SNaP Wound Care System is a novel, ultraportable device that delivers negative-pressure wound therapy without the use of an electrically powered pump.
   Methods: At an outpatient wound care clinic, 21 subjects with difficult-to-treat lower extremity ulcers received treatment with the SNaP System and were evaluated for wound healing for up to 4 months. Outcomes were then compared with 42 patient-matched controls treated at the same center with modern wound care protocols that included the use of Apligraf, Regranex, and skin grafting.
   Results: In the SNaP-treated group, 100 percent of subjects demonstrated improvement in wound size and 86 percent (18 of 21) exhibited a statistically significant healing trend (p < 0.05). Using Kaplan-Meier estimates of wound healing, SNaP-treated subjects healed in an average of 74.25 +/- 20.1 days from the start of SNaP treatment and the matched controls healed in an average of 148.73 +/- 63.1 days from the start of conventional treatment. This significantly faster healing time represents a 50 percent absolute reduction in time to healing (p < 0.0001) for subjects treated with the SNaP device.
   Conclusions: The findings reported here for the SNaP Wound Care System are similar to published reports for powered negative-pressure wound therapy devices for the treatment of highly challenging lower extremity wounds. This study suggests that the SNaP Wound Care System may be a useful addition to the techniques available to the wound care clinician. (Mast. Reconstr. Stew. 126: 1253, 2010.)
C1 [Schubart, Peter J.] OConnor Hosp, OConnor Wound Care Clin, San Jose, CA 95128 USA.
   Stanford Univ, Dept Surg, Div Plast & Reconstruct Surg, Sch Med, Stanford, CA 94305 USA.
   Stanford Univ, Div Vasc Surg, Dept Surg, Sch Med, Stanford, CA 94305 USA.
C3 Stanford University; Stanford University
RP Schubart, PJ (通讯作者)，OConnor Hosp, OConnor Wound Care Clin, 125 Ciro Ave,Suite 201, San Jose, CA 95128 USA.
EM schubart@ix.netcom.com
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Barber C, 2008, J Wound Care, V17, P517
   BORGQUIST O, 2009, 24 ANN CLIN S ADV SK
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   Capobianco Claire M, 2009, Clin Podiatr Med Surg, V26, P619, DOI 10.1016/j.cpm.2009.08.002
   Edmonds M, 2009, INT J LOW EXTR WOUND, V8, P11, DOI 10.1177/1534734609331597
   FONG KD, WOUNDS IN PRESS
   Fong KD, 2010, PLAST RECONSTR SURG, V125, P1362, DOI 10.1097/PRS.0b013e3181d62b25
   Kalbfleisch J. D., 2011, STAT ANAL FAILURE TI, V360
   Lee E., 1992, STAT METHODS SURVIVA, VSecond
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 12
TC 26
Z9 28
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2010
VL 126
IS 4
BP 1253
EP 1261
DI 10.1097/PRS.0b013e3181ea4559
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 659IB
UT WOS:000282559100011
PM 20885246
DA 2026-07-24
ER
PT J
AU Kane, BJ
   Younan, G
   Helm, D
   Dastouri, P
   Prentice-Mott, H
   Irimia, D
   Chan, RK
   Toner, M
   Orgill, DP
AF Kane, Bartholomew J.
   Younan, George
   Helm, Douglas
   Dastouri, Pouya
   Prentice-Mott, Harrison
   Irimia, Daniel
   Chan, Rodney K.
   Toner, Mehmet
   Orgill, Dennis P.
TI Controlled induction of distributed microdeformation in wounded tissue
   via a microchamber array dressing
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
LA English
DT Article
DE microfabrication; microfluidic devices; negative pressure wound therapy;
   micromechanical forces; wound healing
ID VACUUM-ASSISTED CLOSURE; EXTRACELLULAR-MATRIX; THERAPY;
   MECHANOTRANSDUCTION; PROLIFERATION; CHALLENGES; TENSEGRITY; MECHANISMS;
   DEVICES
AB Mechanical stimuli are known to play an important role in determining the structure and function of living cells and tissues. Recent studies have highlighted the role of mechanical signals in mammalian dermal wound healing. However, the biological link between mechanical stimulation of wounded tissue and the subsequent cellular response has not been fully determined. The capacity for researchers to study this link is partially limited by the lack of instrumentation capable of applying controlled mechanical stimuli to wounded tissue. The studies outlined here tested the hypothesis that it was possible to control the magnitude of induced wound tissue deformation using a microfabricated dressing composed of an array of open-faced, hexagonally shaped microchambers rendered in a patch of silicone rubber. By connecting the dressing to a single vacuum source, the underlying wounded tissue was drawn up into each of the microchambers, thereby inducing tissue deformation. For these studies, the dressings were applied to full-thickness murine dermal wounds with 200 mmHg vacuum for 12 h. These studies demonstrated that the dressing was capable of inducing wound tissue deformation with values ranging from 11 to 29%. Through statistical analysis, the magnitude of the induced deformation was shown to be a function of both microchamber height and width. These results demonstrated that the dressing was capable of controlling the amount of deformation imparted in the underlying tissue. By allowing the application of mechanical stimulation with varying intensities, such a dressing will enable the performance of sophisticated mechanobiology studies in dermal wound healing. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 95A: 333-340, 2010.
C1 [Younan, George; Helm, Douglas; Dastouri, Pouya; Chan, Rodney K.; Orgill, Dennis P.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
   [Kane, Bartholomew J.] Univ Virginia Hlth Syst, Dept Surg, Div Pediat Surg, Charlottesville, VA 22908 USA.
   [Prentice-Mott, Harrison] Massachusetts Gen Hosp, Ctr Engn Med, BioMEMS Resource Ctr, Boston, MA 02114 USA.
   [Irimia, Daniel; Toner, Mehmet] Massachusetts Gen Hosp, Ctr Engn Med & Surg Serv, Boston, MA 02114 USA.
   [Irimia, Daniel; Toner, Mehmet] Harvard Univ, Sch Med, Boston, MA 02114 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; University of Virginia;
   University of Virginia (UVA) Health System; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; Harvard University; Harvard Medical School
RP Orgill, DP (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Irimia, Daniel/S-5404-2019; Orgill, Dennis/H-7596-2019; Chan,
   Rodney/P-6422-2017
OI Irimia, Daniel/0000-0001-7347-2082; Orgill, Dennis/0000-0002-8279-7310;
   Younan, George/0000-0001-8502-4850
FU National Institutes of Health [UL1RR 025758-01, P41 EB002503]
FX Contract grant sponsor: National Institutes of Health; contract grant
   numbers: UL1RR 025758-01, P41 EB002503
CR Ai-Aql ZS, 2008, J DENT RES, V87, P107, DOI 10.1177/154405910808700215
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NR 30
TC 7
Z9 21
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1549-3296
EI 1552-4965
J9 J BIOMED MATER RES A
JI J. Biomed. Mater. Res. Part A
PD NOV
PY 2010
VL 95A
IS 2
BP 333
EP 340
DI 10.1002/jbm.a.32840
PG 8
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 660TF
UT WOS:000282666600001
PM 20607869
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Saaiq, M
   Hameed-ud-Din
   Khan, MI
   Chaudhery, SM
AF Saaiq, Muhammad
   Hameed-ud-Din
   Khan, Muhammad Ibrahim
   Chaudhery, Saud Majid
TI Vacuum-Assisted Closure Therapy as A Pretreatment For Split Thickness
   Skin Grafts
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Open wound; Wound bed preparation; Vacuum assisted closure therapy;
   Vacuum-assisted closure dressing; Split thickness skin graft; Graft take
ID PRESSURE WOUND THERAPY; MANAGEMENT; INJURY
AB Objective. To evaluate the effect of vacuum-assisted closure (VAC) therapy on wound management by measuring the graft take, wound healing time, need for any re-grafting and duration of hospitalization
   Study Design: Single blinded randomized controlled trial.
   Place and Duration of Study This study was carried out in the Department of Plastic and Reconstructive Surgery, Pakistan Institute of Medical Sciences (PIMS), Islamabad, from October 2007 to December 2009
   Methodology: A total of 100 adult patients of either gender with acute traumatic wounds were included. Patients who needed flap coverage as the primary intervention, and those with Diabetes, malignancy, bleeding diathesis were excluded. Half of the patients were randomly assigned to the intervention group and the rest to the control group with lottery method. All wounds were initially subjected to thorough excision Wound bed preparation for STSG (split thickness skin graft) was achieved using 10 days pre-treatment with VAC dressings in the intervention group while employing normal saline gauzes in the control group All patients were subsequently treated with STSG. The primary outcome measure was graft take while the secondary outcome measures included wound healing time, need for any re-grafting and duration of hospital stay Results were compared in both groups using chi-square test.
   Results: Marked differences were found in favour of the VAC therapy group with respect to the various wound management outcome measures studied. i.e. graft take (greater than 95% graft take in 90% of VAC therapy group vs. 18% of controls), wound healing time (2 weeks postgrafting in 90% of VAC therapy group vs. 18% of controls), need for regrafting (none among VAC therapy group vs. 8% of controls) and duration of hospital stay (less than 3 weeks in 90% of VAC therapy group vs. 18% of controls)
   Conclusion: VAC therapy should be employed in the pre-treatment of wounds planned to be reconstructed with STSG, since it has marked advantages in the wound bed preparation compared with the traditional normal saline gauze dressings.
C1 [Saaiq, Muhammad; Hameed-ud-Din; Khan, Muhammad Ibrahim; Chaudhery, Saud Majid] MOs Hosp, PIMS, Dept Plast Surg, Islamabad, Pakistan.
RP Saaiq, M (通讯作者)，MOs Hosp, PIMS, Dept Plast Surg, Room 20, Islamabad, Pakistan.
RI Saaiq, Muhammad/Q-8931-2018
OI Saaiq, Muhammad/0000-0003-1714-0491
CR Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Argenta LC, 2000, ANN PLAS SURG, V45, P335, DOI 10.1097/00000637-200045030-00020
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2006, LANCET, V367, P726, DOI 10.1016/S0140-6736(06)68296-2
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   BREASTED D, 1930, E SMITH SURGICAL PAP
   De Filippo RE, 2002, PLAST RECONSTR SURG, V109, P2450, DOI 10.1097/00006534-200206000-00043
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   MORYKWAS MJ, 2000, ANN PLAST SURG, V45, P335
   Robson MC, 2001, CURR PROB SURG, V38, P65
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   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
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   TRUEMAN P, 2007, POSITION DOCUMENT DE, P5
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NR 27
TC 34
Z9 40
U1 0
U2 1
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD OCT
PY 2010
VL 20
IS 10
BP 675
EP 679
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 661KZ
UT WOS:000282728500010
PM 20943111
DA 2026-07-24
ER
PT J
AU Petzina, R
   Malmsjö, M
   Stamm, C
   Hetzer, R
AF Petzina, Rainer
   Malmsjoe, Malin
   Stamm, Christof
   Hetzer, Roland
TI Major complications during negative pressure wound therapy in
   poststernotomy mediastinitis after cardiac surgery
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RIGHT-VENTRICULAR RUPTURE; CONVENTIONAL
   TREATMENT; RISK-FACTORS; EXPERIENCE; STERNOTOMY; MORTALITY
AB Objective: Negative pressure wound therapy is the first-line treatment modality for poststernotomy mediastinitis in many heart centers. The aim of this study was to analyze major complications and possible preventive methods during negative pressure wound therapy in patients with deep sternal wound infections.
   Methods: We retrospectively analyzed 69 consecutive patients treated with negative pressure wound therapy for poststernotomy mediastinitis between June 2006 and September 2009.
   Results: Five (7.2%) patients sustained major complications during negative pressure wound therapy. Bleeding from coronary artery venous bypass grafts was observed in 4 patients and fulminant bleeding from an infected homograft of the ascending aorta was observed in 1 patient during routine dressing changes of the negative pressure wound therapy system.
   Conclusions: Bleeding is the major complication during negative pressure wound therapy for poststernotomy mediastinitis. Covering the heart with several layers of paraffin gauze is a necessary protective maneuver but cannot completely prevent major complications during negative pressure wound therapy. All operative procedures, including dressing changes, should be performed in the operating room under optimal hygienic and monitoring conditions to increase the salvage rate and to guarantee optimal surgical and anesthesiologic conditions in case of negative pressure wound therapy-related complications. (J Thorac Cardiovasc Surg 2010;140:1133-6)
C1 [Petzina, Rainer; Stamm, Christof; Hetzer, Roland] Deutsch Herzzentrum Berlin, D-13353 Berlin, Germany.
   [Malmsjoe, Malin] Univ Lund Hosp, S-22185 Lund, Sweden.
C3 German Heart Center Berlin; Lund University; Skane University Hospital
RP Petzina, R (通讯作者)，Deutsch Herzzentrum Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM petzina@web.de
RI ; Stamm, Christof/J-5719-2014
OI Maljö, Malin/0000-0001-9849-9599; Petzina, Rainer/0000-0002-0688-5482
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
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NR 16
TC 43
Z9 51
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD NOV
PY 2010
VL 140
IS 5
BP 1133
EP 1136
DI 10.1016/j.jtcvs.2010.06.063
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 665TE
UT WOS:000283057600037
PM 20832086
OA Bronze
DA 2026-07-24
ER
PT J
AU Stiegler, P
   Matzi, V
   Pierer, E
   Hauser, O
   Schaffellner, S
   Renner, H
   Greilberger, J
   Aigner, R
   Maier, A
   Lackner, C
   Iberer, F
   Smolle-Jüttner, FM
   Tscheliessnigg, K
   Stadlbauer, V
AF Stiegler, Philipp
   Matzi, Veronika
   Pierer, Eve
   Hauser, Oliver
   Schaffellner, Silvia
   Renner, Heiko
   Greilberger, Joachim
   Aigner, Reingard
   Maier, Alfred
   Lackner, Carolin
   Iberer, Florian
   Smolle-Juettner, Freyja-Maria
   Tscheliessnigg, Karlheinz
   Stadlbauer, Vanessa
TI Creation of a prevascularized site for cell transplantation in rats
SO XENOTRANSPLANTATION
LA English
DT Article
DE angiogenesis; HEK293; hyperbaric oxygenation; islet cells;
   microencapsulation; vacuum-assisted wound closure; xenotransplantation
ID ENDOTHELIAL GROWTH-FACTOR; HYPERBARIC-OXYGEN TREATMENT;
   VACUUM-ASSISTED-CLOSURE; INOPERABLE PANCREATIC-CARCINOMA;
   MICROENCAPSULATED ISLET GRAFTS; SODIUM CELLULOSE SULFATE; OXIDATIVE
   DNA-DAMAGE; BIOARTIFICIAL PANCREAS; ANTIOXIDANT STATUS; PORCINE ISLETS
AB Introduction:
   Transplanted cells, especially islet cells, are likely to become apoptotic due to local hypoxia leading to graft dysfunction. Isolated pancreatic islet cells depend on the diffusion of oxygen from the surrounding tissue; therefore, access to sufficient oxygen supply is beneficial, particularly when microcapsules are used for immunoisolation in xenotransplantation. The aim of this study was to create a prevascularized site for cell transplantation in rats and test its effectiveness with microencapsulated HEK293 cells.
   Methods:
   The combination of implantation of a foam dressing, vacuum-assisted wound closure (foam+VAC) and hyperbaric oxygenation (HBO) was used in 40 Sprague-Dawley rats. Blood flow and vascular endothelial growth factor (VEGF) levels were determined. Sodium cellulose sulphate (SCS)-microencapsulated HEK293 cells were xenotransplanted into the foam dressing in rats pre-treated with HBO, and angiogenesis and apoptosis were assessed.
   Results:
   Vessel ingrowth and VEGF levels increased depending on the duration of HBO treatment. The area containing the foam was perfused significantly better in the experimental groups when compared to controls. Only a small amount of apoptosis occurs in SCS-microencapsulated HEK293 cells after xenotransplantation.
   Conclusion:
   As ischemia-damaged cells are likely to undergo cell death or loose functionality due to hypoxia, therefore leading to graft dysfunction, the combination foam+VAC and HBO might be a promising method to create a prevascularized site to achieve better results in xenogeneic cell transplantation.
C1 [Stiegler, Philipp; Pierer, Eve; Schaffellner, Silvia; Iberer, Florian; Tscheliessnigg, Karlheinz] Med Univ Graz, Dept Surg, Div Transplantat Surg, A-8036 Graz, Austria.
   [Matzi, Veronika; Renner, Heiko; Maier, Alfred; Smolle-Juettner, Freyja-Maria] Med Univ Graz, Dept Surg, Div Thorac Surg & Hyperbar Med, A-8036 Graz, Austria.
   [Hauser, Oliver] Ziel Biopharma Ltd, Cork, Ireland.
   [Greilberger, Joachim] Med Univ Graz, Ctr Physiol Med, Inst Physiol Chem, A-8036 Graz, Austria.
   [Aigner, Reingard] Med Univ Graz, Dept Radiol, Div Nucl Med, A-8036 Graz, Austria.
   [Lackner, Carolin] Med Univ Graz, Inst Pathol, A-8036 Graz, Austria.
   [Stadlbauer, Vanessa] Med Univ Graz, Dept Internal Med, Div Gastroenterol & Hepatol, A-8036 Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; Medical
   University of Graz; Medical University of Graz; Medical University of
   Graz; Medical University of Graz
RP Stiegler, P (通讯作者)，Med Univ Graz, Dept Surg, Div Transplantat Surg, Auenbruggerpl 29, A-8036 Graz, Austria.
EM philipp.stiegler@meduni-graz.at
OI Stiegler, Philipp/0000-0002-0952-3030; Stadlbauer,
   Vanessa/0000-0001-5508-8271
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NR 79
TC 17
Z9 17
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0908-665X
J9 XENOTRANSPLANTATION
JI Xenotransplantation
PD SEP-OCT
PY 2010
VL 17
IS 5
BP 379
EP 390
DI 10.1111/j.1399-3089.2010.00606.x
PG 12
WC Medicine, Research & Experimental; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Transplantation
GA 667CL
UT WOS:000283170100006
PM 20955294
OA Bronze
DA 2026-07-24
ER
PT J
AU Torbrand, C
   Ugander, M
   Engblom, H
   Arheden, H
   Ingemansson, R
   Malmsjö, M
AF Torbrand, Christian
   Ugander, Martin
   Engblom, Henrik
   Arheden, Hakan
   Ingemansson, Richard
   Malmsjo, Malin
TI Wound contraction and macro-deformation during negative pressure therapy
   of sternotomy wounds
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; OPEN-HEART PROCEDURES; POSTSTERNOTOMY
   MEDIASTINITIS; AGGRESSIVE MANAGEMENT; EARLY INTERVENTION;
   CARDIAC-SURGERY; BLOOD-FLOW; FOUNDATION; EXPERIENCE; INFECTION
AB Background: Negative pressure wound therapy (NPWT) is believed to initiate granulation tissue formation via macro-deformation of the wound edge. However, only few studies have been performed to evaluate this hypothesis. The present study was performed to investigate the effects of NPWT on wound contraction and wound edge tissue deformation.
   Methods: Six pigs underwent median sternotomy followed by magnetic resonance imaging in the transverse plane through the thorax and sternotomy wound during NPWT at 0, -75, -125 and -175 mmHg. The lateral width of the wound and anterior-posterior thickness of the wound edge was measured in the images.
   Results: The sternotomy wound decreased in size following NPWT. The lateral width of the wound, at the level of the sternum bone, decreased from 39 +/- 7 mm to 30 +/- 6 mm at -125 mmHg (p = 0.0027). The greatest decrease in wound width occurred when switching from 0 to -75 mmHg. The level of negative pressure did not affect wound contraction (sternum bone: 32 +/- 6 mm at -75 mmHg and 29 +/- 6 mm at -175 mmHg, p = 0.0897). The decrease in lateral wound width during NPWT was greater in subcutaneous tissue (14 +/- 2 mm) than in sternum bone (9 +/- 2 mm), resulting in a ratio of 1.7 +/- 0.3 (p = 0.0423), suggesting macro-deformation of the tissue. The anterior-posterior thicknesses of the soft tissue, at 0.5 and 2.5 cm laterally from the wound edge, were not affected by negative pressure.
   Conclusions: NPWT contracts the wound and causes macro-deformation of the wound edge tissue. This shearing force in the tissue and at the wound-foam interface may be one of the mechanisms by which negative pressure delivery promotes granulation tissue formation and wound healing.
C1 [Torbrand, Christian; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Torbrand, Christian; Ugander, Martin; Engblom, Henrik; Arheden, Hakan; Ingemansson, Richard; Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
   [Ugander, Martin; Engblom, Henrik; Arheden, Hakan] Lund Univ, Dept Clin Psychol, Lund, Sweden.
   [Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University
RP Malmsjö, M (通讯作者)，Lund Univ, Dept Ophthalmol, Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Ugander, Martin/AAQ-4447-2021; Torbrand, Christian/HIZ-8092-2022
OI Ugander, Martin/0000-0003-3665-2038; Ingemansson,
   Richard/0000-0001-7623-8953; Maljö, Malin/0000-0001-9849-9599; Torbrand,
   Christian/0000-0001-6442-7554
FU Swedish Medical Research Council; Swedish Government; Lund University
   Hospital; Swedish Medical Association; Royal Physiographic Society in
   Lund; Ake Wiberg Foundation; Anders Otto Sward Foundation/Ulrika Eklund
   Foundation; Magnus Bergvall Foundation; Crafoord Foundation; Anna-Lisa
   and Sven-Erik Nilsson Foundation; Jeansson Foundation; Swedish
   Heart-Lung Foundation; Anna and Edvin Berger's Foundation; Marta
   Lundqvist Foundation; Lars Hierta Memorial Foundation; Lund University
   Faculty of Medicine
FX We thank Einar Heiberg, PhD, for valuable help and advice regarding
   image analysis. This study was supported by the Swedish Medical Research
   Council, Lund University Faculty of Medicine, the Swedish Government
   Grant for Clinical Research, Lund University Hospital Research Grants,
   the Swedish Medical Association, the Royal Physiographic Society in
   Lund, the Ake Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika
   Eklund Foundation, the Magnus Bergvall Foundation, the Crafoord
   Foundation, the Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeansson
   Foundation, the Swedish Heart-Lung Foundation, Anna and Edvin Berger's
   Foundation, the Marta Lundqvist Foundation, and the Lars Hierta Memorial
   Foundation.
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NR 30
TC 22
Z9 23
U1 0
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD SEP 30
PY 2010
VL 5
AR 75
DI 10.1186/1749-8090-5-75
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 668TD
UT WOS:000283292200001
PM 20920290
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Weidenhagen, R
   Hartl, WH
   Gruetzner, KU
   Eichhorn, ME
   Spelsberg, F
   Jauch, KW
AF Weidenhagen, Rolf
   Hartl, Wolfgang H.
   Gruetzner, Klaus U.
   Eichhorn, Martin E.
   Spelsberg, Fritz
   Jauch, Karl W.
TI Anastomotic Leakage After Esophageal Resection: New Treatment Options by
   Endoluminal Vacuum Therapy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID ASSISTED CLOSURE THERAPY; ENDOSCOPIC TREATMENT; CARDIAC-SURGERY; PLASTIC
   STENTS; MANAGEMENT; ESOPHAGOGASTRECTOMY; IMPLANTATION; PERFORATIONS;
   INFECTIONS; CARCINOMA
AB Background. Anastomotic leakage after esophagectomy is an important determinant of early and late morbidity and mortality. Control of the septic focus is essential when treating patients with anastomotic leakages. Surgical and endoscopic treatment options are limited.
   Methods. Between 2005 and 2009, we treated 6 patients who experienced an intrathoracic anastomotic leakage after esophageal resection. After all established therapeutic measures had failed, we explored the feasibility of an endoscopically assisted mediastinal vacuum therapy.
   Results. We were able to heal intrathoracic esophageal leakages in all 6 patients without any local complications and without the need for reoperation. One patient died because of a progressive pneumonia.
   Conclusions. Endoscopic vacuum-assisted closure of anastomotic leakages may help to overcome the limitations that are associated with intermittent endoscopic treatment and conventional drainage therapy. Our preliminary results suggest that this new concept may be suitable for those patients. (Ann Thorac Surg 2010;90:1674-81) (C) 2010 by The Society of Thoracic Surgeons
C1 Univ Munich, Univ Hosp Campus Grosshadern, Dept Surg, D-81377 Munich, Germany.
   Asklepios Ctr Thorac Surg, Gauting, Germany.
C3 University of Munich
RP Weidenhagen, R (通讯作者)，Univ Munich, Dept Surg, Marchioninistr 15, D-81377 Munich, Germany.
EM rolf.weidenhagen@med.uni-muenchen.de
RI Eichhorn, Martin/GRE-9126-2022; hartl, Wolfgang/I-1981-2012
OI Eichhorn, Martin/0000-0002-0362-0374; 
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   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
   Weidenhagen R, 2010, ANN THORAC SURG, V90, P1674, DOI 10.1016/j.athoracsur.2010.07.007
   White RA, 2005, J ORTHOP TRAUMA, V19, P56, DOI 10.1097/00005131-200501000-00011
NR 31
TC 104
Z9 117
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD NOV
PY 2010
VL 90
IS 5
BP 1674
EP 1681
DI 10.1016/j.athoracsur.2010.07.007
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 669LO
UT WOS:000283352200059
PM 20971288
DA 2026-07-24
ER
PT J
AU Inhoff, O
   Faulhaber, J
   Rothhaar, B
   Goerdt, S
   Koenen, W
AF Inhoff, Oliver
   Faulhaber, Joerg
   Rothhaar, Baerbel
   Goerdt, Sergij
   Koenen, Wolfgang
TI Analysis of treatment costs for complex scalp wounds
SO JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
LA English
DT Article
DE costs analysis; soft tissue reconstruction; dermal regeneration
   template; fascia lata; negative pressure therapy; collagen sheet
ID DERMAL REGENERATION TEMPLATE; RANDOMIZED CONTROLLED-TRIAL; MOHS
   MICROGRAPHIC SURGERY; BASAL-CELL CARCINOMA; FASCIA LATA; RECONSTRUCTIVE
   SURGERY; SURGICAL EXCISION; ARTIFICIAL SKIN; MANAGEMENT; DEFECTS
AB P>Background: Two stage reconstructions of deep scalp wounds with exposed calvarial bone require a vital granulation tissue. By evaluating different surgical approaches functional and cosmetic results as well as economic aspects have to be taken into account.
   Patients and Methods: 52 patients undergoing three different surgical procedures for soft tissue reconstruction of complex scalp wounds with exposed bone were included into a retrospective study. All patients underwent a two stage procedure with 3D histologic control, soft tissue reconstruction and final split thickness skin grafting. Soft tissue reconstruction was carried out using allogenic fascia lata, an artificial skin substitute or a negative pressure wound therapy (NPWT). The costs for all used materials as well as personnel and infrastructure were calculated.
   Results: Comparing the costs for the different treatments, the fascia lata group was least costly (4,475 euro) followed by the artificial skin substitute group (4,557 euro). The highest expenses occurred in the NPWT group (7,.521 euro). The artificial skin substitute group had the fewest dressing changes and the shortest treatment time.
   Conclusions: Although dermal regeneration templates are expensive, their use may be economic. NPWT causes high treatment costs due to high daily rental rates and frequent and time-consuming dressing changes.
C1 [Inhoff, Oliver; Faulhaber, Joerg; Goerdt, Sergij; Koenen, Wolfgang] Univ Heidelberg, Mannheim Med Sch, Univ Hosp Mannheim, Dept Dermatol Venerol & Allergol, D-6900 Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg
RP Koenen, W (通讯作者)，UMM, Univ Heidelberg, Fac Mannheim, Klin Dermatol Venerol & Allergol, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
EM wolfgang.koenen@umm.de
RI Koenen, Wolfgang/NUP-5484-2025
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NR 30
TC 15
Z9 16
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1610-0379
J9 J DTSCH DERMATOL GES
JI J. Dtsch. Dermatol. Ges.
PD NOV
PY 2010
VL 8
IS 11
BP 890
EP 896
DI 10.1111/j.1610-0387.2010.07474.x
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 669UP
UT WOS:000283376000005
PM 20629843
DA 2026-07-24
ER
PT J
AU Eisenhardt, SU
   Momeni, A
   Iblher, N
   Penna, V
   Schmidt, Y
   Torio, N
   Stark, GB
   Bannasch, H
AF Eisenhardt, Steffen U.
   Momeni, Arash
   Iblher, Niklas
   Penna, Vincenzo
   Schmidt, Yvonne
   Torio, Nestor
   Stark, G. Bjoern
   Bannasch, Holger
TI The Use of the Vacuum-Assisted Closure in Microsurgical Reconstruction
   Revisited: Application in the Reconstruction of the Posttraumatic Lower
   Extremity
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE Negative pressure wound therapy; reconstructive surgery; free flap
   surgery
ID IMPLANTABLE DOPPLER PROBE; MICROVASCULAR FREE FLAPS; PERFORATOR FLAP;
   WOUND CONTROL; SKIN-GRAFTS; FOUNDATION; EXPERIENCE
AB Introduction of vacuum-assisted closure (VAC) system into clinical practice has revolutionized wound care. Despite its multiple advantages, however, the VAC is only rarely used in the setting of microsurgical reconstruction. Concerns have been the inability to clinically monitor the flap as well the possibility of flap compression by the device. The authors put their postoperative treatment concept of applying the VAC to free flaps to the test by reviewing their experience with this concept in patients undergoing microsurgical reconstruction of posttraumatic lower-extremity soft tissue defects. Twenty-six patients (22 male, 4 female) were included in this study. Use of the implantable Doppler probe allowed for postoperative flap monitoring. Two flap failures were observed, both in patients with peripheral vascular disease. In conclusion, using the VAC device in the setting of microsurgical reconstruction is safe and allows for increased patient comfort.
C1 [Eisenhardt, Steffen U.; Momeni, Arash; Iblher, Niklas; Penna, Vincenzo; Schmidt, Yvonne; Torio, Nestor; Stark, G. Bjoern; Bannasch, Holger] Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, D-79106 Freiburg, Germany.
   [Momeni, Arash] Stanford Univ, Med Ctr, Div Plast & Reconstruct Surg, Stanford, CA 94305 USA.
C3 University of Freiburg; Stanford University
RP Eisenhardt, SU (通讯作者)，Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Hugstetter Str 55, D-79106 Freiburg, Germany.
EM steffen.eisenhardt@uniklinik-freiburg.de
RI Momeni, Arash/AAV-8300-2020; Eisenhardt, Steffen Ulrich/AAF-8033-2021
OI Momeni, Arash/0000-0002-6452-751X; Eisenhardt, Steffen
   Ulrich/0000-0003-4471-3160
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
   Bannasch H, 2008, MICROSURG, V28, P412, DOI 10.1002/micr.20512
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NR 25
TC 27
Z9 34
U1 0
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD NOV
PY 2010
VL 26
IS 9
BP 615
EP 621
DI 10.1055/s-0030-1267378
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 670UF
UT WOS:000283452100007
PM 20922656
DA 2026-07-24
ER
PT J
AU Goldstein, JA
   Iorio, ML
   Brown, B
   Attinger, CE
AF Goldstein, Jesse A.
   Iorio, Matthew L.
   Brown, Benjamin
   Attinger, Christopher E.
TI The Use of Negative Pressure Wound Therapy for Random Local Flaps at the
   Ankle Region
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE lower extremity; negative pressure wound therapy; plastic surgery;
   reconstruction; wound
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY; DEVICE; RECONSTRUCTION;
   GRAFTS; LEG
AB Local random flaps are seldom used for reconstruction of complex ankle wounds because of concern for flap failure attributable to vascular compromise and tissue edema. Negative pressure wound therapy has been shown to improve perfusion and limit tissue edema. The objective of this study was to demonstrate the utility of negative pressure wound therapy in improving outcomes for local flaps of the ankle. Ten consecutive patients presenting with complex ankle wounds and reconstructed using local flaps were treated with negative pressure wound therapy postoperatively. Type of flap, immediate and long-term outcomes, and complications were assessed. Seventeen local flaps were performed on 10 patients to reconstruct their ankle wounds. Mean follow up was 88 days. All flaps healed without tissue compromise or necrosis. Only one partial dehiscence and no infections were observed. This study demonstrates that negative pressure therapy may contribute to the viability of random local flaps by decreasing venous congestion. Our experience using negative pressure wound therapy on local flaps suggests that it may serve as a useful adjunct to ensure successful closure of high-risk wounds. (C) 2010 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Goldstein, Jesse A.; Iorio, Matthew L.; Brown, Benjamin; Attinger, Christopher E.] Georgetown Univ Hosp, Dept Plast Surg, Washington, DC 20007 USA.
C3 Georgetown University
RP Goldstein, JA (通讯作者)，Georgetown Univ Hosp, Dept Plast Surg, 3800 Reservoir Rd NW,Bles Bldg,1st Floor, Washington, DC 20007 USA.
EM goldstein.jesse@gmail.com
RI Iorio, Matthew/G-5490-2017
OI Iorio, Matthew/0000-0003-1293-9640
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Attinger CE, 2002, PLAST RECONSTR SURG, V109, P1281, DOI 10.1097/00006534-200204010-00011
   Attinger CE, 2006, PLAST RECONSTR SURG, V117, p72S, DOI 10.1097/01.prs.0000225470.42514.8f
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Clemens Mark W, 2008, Foot Ankle Clin, V13, P145, DOI 10.1016/j.fcl.2007.12.001
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   Hallock GG, 2000, J TRAUMA, V48, P913, DOI 10.1097/00005373-200005000-00016
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   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
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NR 20
TC 31
Z9 40
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD NOV-DEC
PY 2010
VL 49
IS 6
BP 513
EP 516
DI 10.1053/j.jfas.2010.07.001
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 672LS
UT WOS:000283585400007
PM 20801691
DA 2026-07-24
ER
PT J
AU Pan, A
   Cauda, R
   Concia, E
   Esposito, S
   Sganga, G
   Stefani, S
   Nicastri, E
   Lauria, FN
   Carosi, G
   Moroni, M
   Ippolito, G
AF Pan, Angelo
   Cauda, Roberto
   Concia, Ercole
   Esposito, Silvano
   Sganga, Gabriele
   Stefani, Stefania
   Nicastri, Emanuele
   Lauria, Francesco N.
   Carosi, Giampiero
   Moroni, Mauro
   Ippolito, Giuseppe
CA GISIG Working Grp Complicated Skin
TI Consensus document on controversial issues in the treatment of
   complicated skin and skin-structure infections
SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Staphylococcus aureus; MRSA; Complicated skin and skin-structure
   infections; Topical negative therapy; Antibiotic therapy
ID SOFT-TISSUE INFECTIONS; RESISTANT-STAPHYLOCOCCUS-AUREUS; VACUUM-ASSISTED
   CLOSURE; GRAM-POSITIVE BACTERIA; ONCE-WEEKLY DALBAVANCIN; DOUBLE-BLIND
   TRIAL; STANDARD THERAPY; POSTSTERNOTOMY MEDIASTINITIS;
   VANCOMYCIN-AZTREONAM; DEFINITIVE CLOSURE
AB Background: Complicated skin and skin-structure infections (cSSSI), including surgical site infections (SSI), cellulitis, and abscesses, have been extensively studied, but controversial issues still exist.
   Controversial issues: The aim of this GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) working group - a panel of multidisciplinary experts - was to define recommendations for the following controversial issues: (1) What is the efficacy of topical negative pressure wound treatment as compared to standard of care in the treatment of severe surgical site infections, i.e., deep infections, caused by Gram-positive microorganisms? (2) Which are the most effective antibiotic therapies in the treatment of cSSSI, including SSI, due to methicillin-resistant staphylococci? Results are presented and discussed.
   Methods: A systematic literature search using the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and www.clinicaltrials.gov databases of randomized controlled trials and/or non-randomized studies was performed. A matrix was created to extract evidence from original studies using the CONSORT method to evaluate randomized clinical trials and the Newcastle-Ottawa Quality Assessment Scale for case-control studies, longitudinal cohorts, and retrospective studies. The GRADE method was used for grading quality of evidence. An analysis of the studies published between 1990 and 2008 is presented and discussed in detail. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
C1 [Pan, Angelo] Ist Ospitalieri Cremona, Div Malattie Infett & Trop, Cremona, Italy.
   [Cauda, Roberto] Univ Cattolica Sacro Cuore, Ist Malattie Infett, Rome, Italy.
   [Concia, Ercole] Univ Verona, Dipartimento Malattie Infett, I-37100 Verona, Italy.
   [Esposito, Silvano] Univ Naples 2, Dipartimento Malattie Infett, Naples, Italy.
   [Sganga, Gabriele] Univ Cattolica Sacro Cuore, Ist Clin Chirurg, Rome, Italy.
   [Stefani, Stefania] Univ Catania, Dipartimento Microbiol, I-95124 Catania, Italy.
   [Nicastri, Emanuele; Lauria, Francesco N.; Ippolito, Giuseppe] Ist Nazl Malattie Infett Lazzaro Spallanzani, Rome, Italy.
   [Carosi, Giampiero] Univ Brescia, Ist Malattie Infett & Trop, Brescia, Italy.
   [Moroni, Mauro] Univ Milan, Ist Malattie Infett & Trop, Milan, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Verona; Universita della Campania Vanvitelli; Catholic
   University of the Sacred Heart; IRCCS Policlinico Gemelli; University of
   Catania; IRCCS Lazzaro Spallanzani; University of Brescia; University of
   Milan
RP Pan, A (通讯作者)，Ist Ospitalieri Cremona, Div Malattie Infett & Trop, Cremona, Italy.
EM angelo.pan1@tin.it
RI ; STEFANI, STEFANIA/K-8075-2016; Ippolito, Giuseppe/J-7207-2017;
   nicastri, emanuele/K-7780-2016
OI CAUDA, Roberto/0000-0002-1498-4229; STEFANI,
   STEFANIA/0000-0003-1594-7427; Ippolito, Giuseppe/0000-0002-1076-2979;
   nicastri, emanuele/0000-0002-5606-8712
FU Pfizer; GISIG; GlaxoSmithKline; Gilead; Bristol Myers Squibb; Boehringer
   Ingelheim; Abbott; Merck Sharp Dohme; Novartis farma; Wyeth Lederle;
   Janssen
FX The GISIG Consensus Conference was organized with support from an
   unrestricted educational grant from Pfizer.For the present research, all
   members of the faculty of GISIG received a fee from the organizing
   secretariat of the GISIG Project.Conflict of interest for R. Cauda:
   GlaxoSmithKline, Gilead, Bristol Myers Squibb, Boehringer Ingelheim,
   Pfizer, Abbott, Merck Sharp & Dohme, Wyeth. Funding received from
   GlaxoSmithKline, Gilead, Bristol Myers Squibb, Boehringer Ingelheim,
   Pfizer, Abbott, Merck Sharp & Dohme. S. Esposito has received fees for
   speaking at national and international meetings and for consulting on
   Advisory boards from Pfizer, Novartis farma and Wyeth Lederle. G. Sganga
   has received honoraria for speaking for Pfizer. G. Ippolito and F.N.
   Lauria have received expert opinion fees from Pfizer. E. Nicastri has
   received paid expert opinion from MSD and Pfizer. A. Pan has received
   paid expert opinion fees from Janssen.
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NR 55
TC 17
Z9 19
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1201-9712
EI 1878-3511
J9 INT J INFECT DIS
JI Int. J. Infect. Dis.
PD OCT
PY 2010
VL 14
SU 4
BP S39
EP S53
DI 10.1016/j.ijid.2010.05.007
PG 15
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 675OJ
UT WOS:000283839700007
PM 20851013
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pliakos, I
   Papavramidis, TS
   Mihalopoulos, N
   Koulouris, H
   Kesisoglou, I
   Sapalidis, K
   Deligiannidis, N
   Papavramidis, S
AF Pliakos, Ioannis
   Papavramidis, Theodossis S.
   Mihalopoulos, Nikolaos
   Koulouris, Harilaos
   Kesisoglou, Isaak
   Sapalidis, Konstantinos
   Deligiannidis, Nikolaos
   Papavramidis, Spiros
TI Vacuum-assisted closure in severe abdominal sepsis with or without
   retention sutured sequential fascial closure: A clinical trial
SO SURGERY
LA English
DT Article
ID TOPICAL NEGATIVE-PRESSURE; OPEN ABDOMEN; INTRAABDOMINAL HYPERTENSION;
   INTERNATIONAL-CONFERENCE; COMPARTMENT SYNDROME; WOUND CLOSURE; WALL
   RECONSTRUCTION; TEMPORARY CLOSURE; VENTRAL HERNIA; MANAGEMENT
AB Background. Multiple techniques have been introduced to obtain fascial closure for the open abdomen to minimize morbidity and cost of care. We hypothesized that a modification of the vacuum-assisted closure (VAC) technique that provides constant fascial tension and prevents abdominis rectis retraction would facilitate primary fascial closure and reduce morbidity.
   Methods. In all, 53 patients with severe abdominal sepsis were allocated randomly into 2 groups, and 30 patients were analyzed. In the VAC group, we included patients managed only with the VAC device, whereas the retentions sutured sequential fascial closure (RSSFC) group included patients to whom RSSFC was performed.
   Results. The abdomen was left open for 12 days (P = .0001) with 4.4 +/- 1.35 changes per patient for the VAC group (P = .001) and 8 days with 2.87 +/- 0.74 dressing changes per patient for the RSSFC group, respectively. Abdominal closure was possible in only 6 patients in the VAC group, whereas for the RSSFC group, abdominal closure was achieved in 14 patients (P = .005). Planned hernia was exclusively decided in patients in the VAC group (P = .001). The hospital stay was 17.53 +/- 4.59 days for the VAC group and 11.93 +/- 2.05 days for the RSSFC group (P = .0001). The median initial intra-abdominal pressure (IAP) was 12 mm Hg for the VAC group and 16 mm Hg for the RSSFC group (P < .0001).
   Conclusion. We demonstrated the superiority of RSSFC compared with the single use of the VAC device. In our opinion, sequential fascial closure can immediately begin when abdominal sepsis is controlled. (Surgery 2010;148:947-53.)
C1 [Pliakos, Ioannis; Papavramidis, Theodossis S.; Mihalopoulos, Nikolaos; Koulouris, Harilaos; Kesisoglou, Isaak; Sapalidis, Konstantinos; Deligiannidis, Nikolaos; Papavramidis, Spiros] Aristotle Univ Thessaloniki, Dept Surg 3, AHEPA Univ Hosp, Thessaloniki 56334, Greece.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital
RP Pliakos, I (通讯作者)，Aristotle Univ Thessaloniki, Dept Surg 3, AHEPA Univ Hosp, M Sotyros 25, Thessaloniki 56334, Greece.
EM plliakos@hotmail.com
RI Sapalidis, Konstantinos/AAV-2866-2021; Papavramidis,
   Theodossis/E-8260-2011; Papavramidis, Theodossis/E-8260-2011;
   Michalopoulos, Nickos/I-6159-2013
OI Papavramidis, Theodossis/0000-0002-7097-9889; Papavramidis,
   Theodossis/0000-0002-7097-9889; Michalopoulos,
   Nickos/0000-0002-7740-4922
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NR 47
TC 60
Z9 68
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD NOV
PY 2010
VL 148
IS 5
BP 947
EP 953
DI 10.1016/j.surg.2010.01.021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 676CP
UT WOS:000283888000006
PM 20227097
DA 2026-07-24
ER
PT J
AU Rudzka-Nowak, A
   Luczywek, P
   Gajos, MJ
   Piechota, M
AF Rudzka-Nowak, Alina
   Luczywek, Pawel
   Gajos, Maciej Jerzy
   Piechota, Mariusz
TI Application of manuka honey and GENADYNE A4 negative pressure wound
   therapy system in a 55-year-old woman with extensive phlegmonous and
   necrotic lesions in the abdominal integuments and lumbar region after
   traumatic rupture of the colon
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Manuka honey; negative pressure wound therapy system; traumatic rupture
   of the colon
ID ANTIBACTERIAL ACTIVITY; COLORECTAL-CANCER; NEW-ZEALAND; IDENTIFICATION;
   STRAINS; CELLS
AB Background: Antibiotic resistance of bacteria is on the rise and thus, the discovery of alternative therapeutic agents is urgently needed. Honey possesses good therapeutic potential, including wound healing properties and antimicrobial activity.
   Case Report: The authors report on the case of a 55-year-old woman with extensive phlegmonous and necrotic lesions of the abdominal integuments and the lumbar area following traumatic colonic rupture, treated with Manuka honey wound dressings and the GENADYNE A4 negative pressure wound healing system.
   Conclusions: The application of the Manuka honey and the GENADYNE A4 negative pressure wound healing system in treating phlegmonous lesions of the abdominal integuments after rupture of the colon brought good effects, ultimately enabling skin autografting on the wound site and complete wound healing.
C1 [Rudzka-Nowak, Alina; Luczywek, Pawel; Gajos, Maciej Jerzy; Piechota, Mariusz] Univ Hosp Lodz, Mil Med Acad, Dept Anaesthesiol & Intens Therapy, PL-90647 Lodz, Poland.
RP Piechota, M (通讯作者)，Univ Hosp Lodz, Mil Med Acad, Dept Anaesthesiol & Intens Therapy, Hallera Sq 1, PL-90647 Lodz, Poland.
EM mariuszpiechota@poczta.onet.pl
RI Piechota, Mariusz/L-7246-2019
OI Piechota, Mariusz/0000-0002-4269-6742
FU Military Medical Academy University Hospital in Lodz
FX Military Medical Academy University Hospital in Lodz
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NR 26
TC 13
Z9 14
U1 0
U2 6
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PY 2010
VL 16
IS 11
BP CS138
EP CS142
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 677KM
UT WOS:000283991300015
PM 20980964
DA 2026-07-24
ER
PT J
AU Chen, M
   Ling, Y
   Yang, BB
AF Chen, Ming
   Ling, Yi
   Yang, Beibei
TI Management of late cervical esophageal perforation
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Esophageal perforation; late cervical management; primary repair
ID MEDIASTINITIS; INFECTION
AB BACKGROUND
   We aimed to identify different methods of treating late perforation of the cervical esophagus.
   METHODS
   Ten late cervical esophageal perforations were caused by foreign bodies. The subjects were divided into three groups according to their diagnosis and treatment as follows: Group I: Cases with cervical abscess were drained by lateral cervical incision and primarily repaired, Group II: Cases with cervical abscess were drained by lateral cervical incision, and any foreign body granulomas found were removed, and Group III: Foreign bodies were removed. All cases were given broad-spectrum antibiotics and were prohibited from any oral food, except Case 5.
   RESULTS
   All patients recovered without mortality and retained normal swallow function. The time for treatment in each group was different.
   CONCLUSION
   The conservative management of removal of foreign body, prohibition of oral food and administration of broad-spectrum antibiotics is supported. Perforations with the presence of abscess can be surgically treated by debridement closure combined with strip muscle flap repair and irrigation drainage. Granuloma can be removed by lateral cervical incision and vacuum sealing drainage.
C1 [Chen, Ming; Ling, Yi; Yang, Beibei] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Otolaryngol, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Yang, BB (通讯作者)，Jiefang Rd 88, Hangzhou 310009, Zhejiang, Peoples R China.
EM yangbb1959@sina.com
RI Chen, Mingyu/R-6690-2019
CR Baum ED, 2008, ENT-EAR NOSE THROAT, V87, P44, DOI 10.1177/014556130808700115
   Breigeiron R, 2008, DIS ESOPHAGUS, V21, P266, DOI 10.1111/j.1442-2050.2007.00779.x
   Brinster CJ, 2004, ANN THORAC SURG, V77, P1475, DOI 10.1016/j.athoracsur.2003.08.037
   Demirbag S, 2005, CLIN PEDIATR, V44, P131, DOI 10.1177/000992280504400204
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   Kay Marsha, 2005, Curr Gastroenterol Rep, V7, P212, DOI 10.1007/s11894-005-0037-6
   LAM HC, 2003, ENT-EAR NOSE THROAT, V82, P789
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   Ökten I, 2001, SURG TODAY, V31, P36
   Righini CA, 2008, WORLD J GASTROENTERO, V14, P1450, DOI 10.3748/wjg.14.1450
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   Zumbro GL, 2002, AM SURGEON, V68, P36
NR 17
TC 4
Z9 6
U1 0
U2 2
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD NOV 1
PY 2010
VL 16
IS 6
BP 511
EP 515
PG 5
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 678PM
UT WOS:000284091700006
PM 21153943
DA 2026-07-24
ER
PT J
AU Khan, MAA
   Chipp, E
   Hardwicke, J
   Srinivasan, K
   Shaw, S
   Rayatt, S
AF Khan, Muhammad Adil Abbas
   Chipp, Elizabeth
   Hardwicke, Joseph
   Srinivasan, Karthik
   Shaw, Simon
   Rayatt, Sukh
TI The use of Dermal Regeneration Template (Integra®) for reconstruction of
   a large full-thickness scalp and calvarial defect with exposed dura
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Scalp reconstruction; Skin substitute; Integra (R); Dura;
   Vacuum-Assisted Closure
ID ARTIFICIAL DERMIS
AB The reconstruction of large full-thickness scalp defects remains a challenge, particularly when dura is exposed. Various reconstructive methods have been described in the past. Dermal Regeneration Templates (DRTs) are becoming increasingly popular in the management of acute wounds as well as the reconstruction of burn scars, oncological defects and various other complex reconstructive problems. We describe a case where Integra (R) was successfully used together with a Vacuum-Assisted Closure (VAC) dressing to reconstruct a full-thickness scalp defect with exposed dura. Surgical technique is discussed as well as problems encountered during the case and possible solutions. (C) 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Khan, Muhammad Adil Abbas; Chipp, Elizabeth; Hardwicke, Joseph; Srinivasan, Karthik; Rayatt, Sukh] Univ Hosp N Staffordshire, Dept Plast & Reconstruct Surg, Stoke On Trent ST4 6QG, Staffs, England.
   [Shaw, Simon] Univ Hosp N Staffordshire, Dept Neurosurg, Stoke On Trent ST4 6QG, Staffs, England.
C3 Keele University; Keele University
RP Chipp, E (通讯作者)，Univ Hosp N Staffordshire, Dept Plast & Reconstruct Surg, Newcastle Rd, Stoke On Trent ST4 6QG, Staffs, England.
EM elizabeth_chipp@hotmail.com
CR Gonyon DL Jr, 2003, ANN PLAS SURG, V50, P315, DOI 10.1097/01.SAP.0000046788.45508.A3
   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   Khashab Mostafa El, 2009, J Neurosurg Pediatr, V4, P523, DOI 10.3171/2009.7.PEDS09220
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   Moiemen NS, 2001, PLAST RECONSTR SURG, V108, P93, DOI 10.1097/00006534-200107000-00015
   Momoh AO, 2009, ANN PLAS SURG, V62, P656, DOI 10.1097/SAP.0b013e318180c913
   Tufaro AP, 2007, PLAST RECONSTR SURG, V120, P638, DOI 10.1097/01.prs.0000270298.68331.8a
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   Yeong EK, 2006, BURNS, V32, P375, DOI 10.1016/j.burns.2005.08.015
NR 10
TC 42
Z9 46
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2010
VL 63
IS 12
BP 2168
EP 2171
DI 10.1016/j.bjps.2010.03.017
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 683HE
UT WOS:000284463500056
PM 20335087
DA 2026-07-24
ER
PT J
AU Wade, C
   Wolf, SE
   Salinas, R
   Jones, JA
   Rivera, R
   Hourigan, L
   Baskin, T
   Linfoot, J
   Mann, EA
   Chung, K
   Dubick, M
AF Wade, Charles
   Wolf, Steven E.
   Salinas, Reuben
   Jones, John A.
   Rivera, Racheal
   Hourigan, Leslie
   Baskin, Toney
   Linfoot, John
   Mann, Elizabeth A.
   Chung, Kevin
   Dubick, Michael
TI Loss of Protein, Immunoglobulins, and Electrolytes in Exudates From
   Negative Pressure Wound Therapy
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Article
DE negative-pressure wound therapy; wounds and injuries; exudates and
   transudates; carrier proteins, nutrition requirements, nitrogen
ID NUTRITIONAL SUPPORT; ENTERAL NUTRITION; GUIDELINES
AB Background: A relatively new technology in wound care, negative pressure wound therapy (NPWT), has become widely used for the management of open abdomens and soft tissue wounds and provides a means to collect wound exudate to quantify protein loss.
   Methods: A prospective observational study was conducted in surgical, trauma, or burn patients (8 patients with open abdomens and 9 patients with acute soft tissue wounds on NPWT). NPWT exudate was collected and assayed to characterize loss of protein, electrolyte, and immunoglobulins over multiple days of NPWT.
   Results: Total protein was present in open abdomen NPWT exudate, 2.9 +/- 0.9 g/dL. In the soft tissue wound exudate, a similar mean concentration was found, 2.59 +/- 0.6 g/dL (P = .34). Exudate concentrations of albumin, urea nitrogen, immunoglobulins, and electrolytes between wound types were also not significantly different. There were significant (P = .03) differences in the median volume of exudate, 1031 mL/d for open abdomens in contrast to 245 mL/d soft tissue wounds. Therefore, 24-hour losses of proteins and electrolytes were greater in patients with open abdomens than soft tissue wounds. Mean total protein loss was 25 +/- 17 g/d for open abdomens and 8 +/- 5 g/d for soft tissue wounds.
   Conclusion: There are significant losses of proteins in wound exudate. As there is no significant difference in the concentration of total protein between wound type, the rate of loss may be calculated as 2.9 g/dL times the volume of wound exudate. The rate of protein loss from wounds is similar to the presently assumed insensible loss rate of 12-25 g/d.(Nutr Clin Pract. 2010; 25:510-516)
C1 [Hourigan, Leslie] Dept 3851, Ft Sam Houston, TX 78234 USA.
RP Hourigan, L (通讯作者)，Dept 3851, Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM leslie.houri-gan@us.army.mil
OI Wolf, Steven/0000-0003-2972-3440
FU DOD-Department of the Army
FX Dr. Wade was supported by DOD-Department of the Army.
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   WAXMAN K, 1987, J TRAUMA, V27, P136, DOI 10.1097/00005373-198702000-00006
   VAC THERAPY WORKS
NR 24
TC 49
Z9 54
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD OCT
PY 2010
VL 25
IS 5
BP 510
EP 516
DI 10.1177/0884533610379852
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 688JB
UT WOS:000284844500010
PM 20962311
OA Bronze
DA 2026-07-24
ER
PT J
AU Blazquez, D
   Ruiz-Contreras, J
   Fernández-Cooke, E
   González-Granado, I
   Delgado, MD
   Menendez, MT
   Rodriguez-Gil, Y
   Ballen, A
   Del Palacio, A
AF Blazquez, Daniel
   Ruiz-Contreras, Jesus
   Fernandez-Cooke, Elisa
   Gonzalez-Granado, Ignacio
   Dolores Delgado, Maria
   Teresa Menendez, Maria
   Rodriguez-Gil, Yolanda
   Ballen, Aida
   Del Palacio, Amalia
TI Lichtheimia corymbifera subcutaneous infection successfully
   treated with amphotericin B, early debridement, and vacuum-assisted
   closure
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Lichtheimia corymbifera; Mycocladus corymbifer; Absidia corymbifera;
   Zygomycosis; Vacuum-assisted closure; Amphotericin
ID MUCORMYCOSIS; ZYGOMYCOSIS; MANAGEMENT; IDENTIFICATION; MYCOCLADUS
AB Lichtheimia corymbifera (syn. Absidia corymbifera, Mycocladus corymbifer) is an ubiquitous cosmopolitan mold that can cause primary cutaneous and deep tissue infection in healthy individuals. We report a subcutaneous L. corymbifera infection in a 13-year-old immune-competent child, with a severe traumatic injury, with a successful outcome after early diagnosis and treatment with lipid amphotericin B, early debridement, and vacuum-assisted closure (VAC). (C) 2010 Elsevier Inc. All rights reserved.
C1 [Blazquez, Daniel; Ruiz-Contreras, Jesus; Fernandez-Cooke, Elisa; Gonzalez-Granado, Ignacio] Hosp Univ 12 Octubre, Dept Pediat, Madrid, Spain.
   [Dolores Delgado, Maria] Hosp Univ 12 Octubre, Dept Pediat Surg, Madrid, Spain.
   [Teresa Menendez, Maria] Hosp Univ 12 Octubre, Dept Orthopaed Surg, Madrid, Spain.
   [Rodriguez-Gil, Yolanda; Ballen, Aida] Hosp Univ 12 Octubre, Dept Pathol, Madrid, Spain.
   [Del Palacio, Amalia] Hosp Univ 12 Octubre, Dept Microbiol, Madrid, Spain.
C3 Hospital Universitario 12 de Octubre; Hospital Universitario 12 de
   Octubre; Hospital Universitario 12 de Octubre; Hospital Universitario 12
   de Octubre; Hospital Universitario 12 de Octubre
RP Blazquez, D (通讯作者)，Hosp Univ 12 Octubre, Dept Pediat, Madrid, Spain.
EM danielblazquez@hotmail.com
RI ; Blázquez-Gamero, Daniel/ABE-9367-2020
OI Rodriguez Gil, Yolanda/0000-0002-4811-5486; RUIZ-CONTRERAS,
   JESUS/0000-0002-2788-7524; Blázquez-Gamero, Daniel/0000-0001-6483-8329;
   Fernández-Cooke, Elisa/0000-0002-5921-8261
CR Alastruey-Izquierdo A, 2010, J CLIN MICROBIOL, V48, P2154, DOI 10.1128/JCM.01744-09
   Almaslamani M, 2009, MED MYCOL, V47, P532, DOI 10.1080/13693780802595746
   Bialek R, 2005, J CLIN PATHOL, V58, P1180, DOI 10.1136/jcp.2004.024703
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   Chamilos G, 2008, CLIN INFECT DIS, V47, P503, DOI 10.1086/590004
   Garbino J, 2005, J Infect, V51, pe135, DOI 10.1016/j.jinf.2004.11.002
   Rickerts V, 2006, MYCOSES, V49, P27, DOI 10.1111/j.1439-0507.2006.01299.x
   Schwarz P, 2006, J CLIN MICROBIOL, V44, P340, DOI 10.1128/JCM.44.2.340-349.2006
   Spellberg B, 2005, CLIN MICROBIOL REV, V18, P556, DOI 10.1128/CMR.18.3.556-569.2005
   Spellberg B, 2009, CLIN INFECT DIS, V48, P1743, DOI 10.1086/599105
   Zaoutis TE, 2007, PEDIATR INFECT DIS J, V26, P723, DOI 10.1097/INF.0b013e318062115c
NR 11
TC 13
Z9 14
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD DEC
PY 2010
VL 45
IS 12
BP E13
EP E15
DI 10.1016/j.jpedsurg.2010.08.011
PG 3
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 688SM
UT WOS:000284873300004
PM 21129524
DA 2026-07-24
ER
PT J
AU Costache, V
   Gaudreau, G
   Houde, C
   Rodière, M
   Hacini, R
   Blin, D
   Chavanon, O
AF Costache, V.
   Gaudreau, G.
   Houde, C.
   Rodiere, M.
   Hacini, R.
   Blin, D.
   Chavanon, O.
TI The assosciation of VAC® therapy, titanium plates osteosynthesis and
   bilateral pectoral muscle flaps in the management of postoperative
   mediastinitis in an obese and diabetic patient
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Postoperative mediastinitis; Titanium plates osteosynthesis; Negative
   pressure therapy; Bilateral pectoral muscle flaps
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND-INFECTION; POSTSTERNOTOMY
   MEDIASTINITIS; MEDIAN STERNOTOMY; HEART-SURGERY; RECONSTRUCTION;
   DEHISCENCE; FIXATION
AB Postoperative mediastinitis is one of the most worrisome complications after heart surgery. Until now there is no universally accepted strategy in the management of this infectious complication. Recently, various novel techniques like negative pressure therapy and titanium plates sternal reconstruction have allowed a dramatic decrease of mortality and morbidity after mediastinitis. We report the case of a diabetic patient suffering from morbid obesity who developed a severe postoperative mediastinitis after a coronary artery bypass; she was successfully treated by combining negative pressure therapy, titanium plates osteosynthesis and bilateral pectoral muscle flaps. (C) 2009 Elsevier Masson SAS. All rights reserved.
C1 [Costache, V.; Rodiere, M.; Hacini, R.; Blin, D.; Chavanon, O.] Univ Med Gr T Popa, CHU Grenoble, Serv Chirurg Cardiaque, F-38043 Grenoble 09, France.
   [Gaudreau, G.; Houde, C.] Hop Laval, Serv Chirurg Plast, Quebec City, PQ, Canada.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   CHU Grenoble Alpes; Laval University; Laval University Hospital
RP Costache, V (通讯作者)，Univ Med Gr T Popa, CHU Grenoble, Serv Chirurg Cardiaque, BP 217, F-38043 Grenoble 09, France.
EM vcostache@chu-grenoble.fr
RI CHAVANON, Olivier/AAC-8171-2019; Costache, Victor/AFC-8705-2022
OI CHAVANON, Olivier/0000-0001-8625-691X; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baskett RJF, 1999, ANN THORAC SURG, V67, P462, DOI 10.1016/S0003-4975(98)01195-3
   Cicilioni OJ, 2005, PLAST RECONSTR SURG, V115, P1297, DOI 10.1097/01.PRS.0000156918.15595.85
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
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   Guedon C, 1994, Ann Chir Plast Esthet, V39, P191
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   Losanoff JE, 2002, CARDIOVASC SURG, V10, P102, DOI 10.1016/S0967-2109(01)00128-4
   Mohammadi S, 2007, CIRCULATION, V116, pE142, DOI 10.1161/CIRCULATIONAHA.107.706028
   Molina JE, 2006, J THORAC CARDIOV SUR, V132, P782, DOI 10.1016/j.jtcvs.2006.06.008
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   OTTINO G, 1987, ANN THORAC SURG, V44, P173, DOI 10.1016/S0003-4975(10)62035-8
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Thompson JT, 2007, CLIN PLAST SURG, V34, P673, DOI 10.1016/j.cps.2007.07.005
   Tocco MP, 2009, EUR J CARDIO-THORAC, V35, P833, DOI 10.1016/j.ejcts.2008.12.036
   Voss B, 2008, EUR J CARDIO-THORAC, V34, P139, DOI 10.1016/j.ejcts.2008.03.030
NR 23
TC 2
Z9 2
U1 0
U2 8
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD DEC
PY 2010
VL 55
IS 6
BP 597
EP 602
DI 10.1016/j.anplas.2009.08.002
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 691MM
UT WOS:000285084600014
PM 19942336
DA 2026-07-24
ER
PT J
AU Al-Subhi, FS
   Zuker, RM
   Cole, WG
AF Al-Subhi, F. S.
   Zuker, R. M.
   Cole, W. G.
TI Vacuum-assisted closure as a surgical assistant in life-threatening
   necrotizing fasciitis in children
SO CANADIAN JOURNAL OF PLASTIC SURGERY
LA English
DT Article
DE Acute; Fasciitis; Necrotizing; Vacuum-assisted negative pressure
AB Necrotizing fasciitis is a severe soft tissue infection that can involve skin, subcutaneous fat, fascia and muscle. It can result in devastating sequelae including tissue necrosis, sepsis, toxic shock syndrome, cardiopulmonary collapse and death. To control rapidly spreading necrosis, early diagnosis and aggressive surgical treatment with extensive radical debridement of the affected areas is necessary, as well as systemic administration of broad-spectrum antimicrobials and, very often, intensive care support.
   The subatmospheric negative pressure dressing has been previously used in acute and complex wounds management. The concept of using vacuum-assisted closure dressing as another management component is presented in the current article.
C1 [Zuker, R. M.] Hosp Sick Children, Div Plast Surg, Toronto, ON M5G 1X8, Canada.
   Hosp Sick Children, Div Orthoped Surg, Toronto, ON M5G 1X8, Canada.
   Univ Toronto, Dept Surg, Toronto, ON, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto; Hospital for Sick Children (SickKids); University of Toronto
RP Zuker, RM (通讯作者)，Hosp Sick Children, Div Plast Surg, Suite 5416,555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM ronald.zuker@sickkids.ca
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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   Huang WS, 2006, ASIAN J SURG, V29, P133
   Legbo JN, 2005, ANN TROP PAEDIATR, V25, P183, DOI 10.1179/146532805X58111
   Moss RLM, 1996, J PEDIATR SURG, V31, P1142, DOI 10.1016/S0022-3468(96)90104-9
   Taviloglu K, 2005, AM SURGEON, V71, P315
NR 9
TC 11
Z9 16
U1 0
U2 3
PU PULSUS GROUP INC
PI OAKVILLE
PA 2902 S SHERIDAN WAY, OAKVILLE, ONTARIO L6J 7L6, CANADA
SN 1195-2199
J9 CAN J PLAST SURG
JI Can. J. Plast. Surg.
PD WIN
PY 2010
VL 18
IS 4
BP 139
EP 142
DI 10.1177/229255031001800412
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 694LY
UT WOS:000285300900008
PM 22131841
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Chen, WF
   Poulakidas, SJ
   Kowal-Vern, A
   Villare, RC
AF Chen, Wei F.
   Poulakidas, Stathis J.
   Kowal-Vern, Areta
   Villare, Robert C.
TI Trephination and Subatmospheric Pressure Therapy in the Management of
   Extremity Exposed Bone
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Subatmospheric pressure therapy; Trephination; Extremity exposed bone
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE DEFECTS; WOUND CONTROL;
   RECONSTRUCTION; EXPERIENCE; 4TH-DEGREE; BURN; TENDON; FLAPS; HAND
AB Background: Distal lower and upper extremity wounds with bone and tendon exposure present unique challenges to reconstructive surgeons. The limitations of the local anatomy usually make simpler reconstructive modalities such as primary closure and skin grafting difficult. As a result, wounds in this area, especially ones with bone or tendon exposures, are classically treated with free tissue transfer.
   Methods: Limb preservation using the combination of bone trephination and subatmospheric pressure therapy is described.
   Results: Six cases with preserved extremities are presented. Three cases illustrate extremity wound with bone and tendon exposure healing through pregrafting wound optimization (bone trephination) with the use of subatmospheric pressure therapy.
   Conclusions: This treatment may offer an alternative method of limb salvage, in cases where flaps or free tissue transfer are not possible or optimal.
C1 [Poulakidas, Stathis J.] Jr Hosp Cook Cty, Sumner L Koch Burn Ctr, Burn Serv, Dept Trauma,Div Burn Serv, Chicago, IL 60612 USA.
   [Chen, Wei F.] Univ Illinois, Dept Plast Surg, Chicago, IL USA.
   [Villare, Robert C.] Mem Hosp Salem Cty Wound & Vasc Ctr, Dept Surg, Vasc Surg Sect, Salem, NJ USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Poulakidas, SJ (通讯作者)，Jr Hosp Cook Cty, Sumner L Koch Burn Ctr, Burn Serv, Dept Trauma,Div Burn Serv, Rm 3229,1901 W Harrison St, Chicago, IL 60612 USA.
EM spoulakdoc1@msn.com
OI Chen, Wei/0000-0002-4163-6641
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NR 26
TC 4
Z9 5
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD DEC
PY 2010
VL 69
IS 6
BP 1591
EP 1596
DI 10.1097/TA.0b013e3181edba5e
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 695RT
UT WOS:000285391000061
PM 21150535
DA 2026-07-24
ER
PT J
AU Kang, D
   Ellis, E
AF Kang, David
   Ellis, Edward, III
TI Applications of Vacuum-Assisted Closure Device in Maxillofacial
   Reconstruction
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID WOUND CONTROL; NECK WOUNDS; MANAGEMENT; PHYSIOLOGY; THERAPY; GENESIS;
   TISSUES; GROWTH; INJURY; HEAD
C1 [Ellis, Edward, III] Univ Texas Hlth Sci Ctr San Antonio, Dept Oral & Maxillofacial Surg, San Antonio, TX 78229 USA.
   [Kang, David] Univ Texas SW Med Ctr Dallas, Dept Oral & Maxillofacial Surg, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas at San Antonio;
   University of Texas System; University of Texas Southwestern Medical
   Center
RP Ellis, E (通讯作者)，Univ Texas Hlth Sci Ctr San Antonio, Dept Oral & Maxillofacial Surg, 7703 Floyd Curl Dr,MC 7908, San Antonio, TX 78229 USA.
EM ellise3@uthscsa.edu
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NR 25
TC 3
Z9 3
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
EI 1531-5053
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD DEC
PY 2010
VL 68
IS 12
BP 3037
EP 3042
DI 10.1016/j.joms.2010.05.047
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 696GU
UT WOS:000285430700017
PM 20970904
DA 2026-07-24
ER
PT J
AU Fong, KD
   Hu, D
   Eichstadt, SL
   Gorell, E
   Munoz, CA
   Lorenz, HP
   Chang, ALS
AF Fong, Kenton D.
   Hu, Dean
   Eichstadt, Shaundra L.
   Gorell, Emily
   Munoz, Claudia A.
   Lorenz, H. Peter
   Chang, Anne Lynn S.
TI Initial Clinical Experience Using a Novel Ultraportable Negative
   Pressure Wound Therapy Device
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; ULCERS; STATE;
   MULTICENTER; ART
AB Background. Traditional negative pressure wound therapy (NPWT) devices, such as the electrically powered V.A.C.(R) Therapy System (KCI, San Antonio, TX), are important tools in the treatment of both acute and chronic wounds. The following describes the first clinical experience using a novel, non-electrically powered, ultraportable NPWT device called the Smart Negative Pressure (SNaP (TM)) Wound Care System (Spiracur, Sunnyvale, CA). Methods. Twelve consecutive adult subjects with chronic wounds ranging from neuropathic wounds to venous stasis ulcers were treated with the SNaP System at an academic outpatient dermatology clinic. Subjects were followed biweekly for complications and wound healing progression over a 4-week period. Results. Of the 12 subjects treated, 5 achieved complete wound healing within 4 weeks. All subjects demonstrated healing after treatment with the SNaP System, and statistically significant healing was reached at 4 weeks (P < 0.01) for patients who were able to complete the treatment protocol. Use of the SNaP System promoted cleaner wound beds with robust granulation tissue formation. There were no serious adverse events directly related to the device. The most common complaint was mild or moderate wound pain in 3 of 12 subjects. Conclusion. These findings support the safety and potential clinical utility of a new ultraportable NPWT device for the treatment of chronic wounds.
C1 [Gorell, Emily; Munoz, Claudia A.; Chang, Anne Lynn S.] Stanford Univ, Sch Med, Dept Dermatol, Stanford, CA 94305 USA.
   [Hu, Dean] Stanford Univ, Dept Biomed Engn, Stanford, CA 94305 USA.
   [Fong, Kenton D.; Hu, Dean] Spiracur Inc, Sunnyvale, CA USA.
   [Fong, Kenton D.; Eichstadt, Shaundra L.; Lorenz, H. Peter] Stanford Univ, Sch Med, Dept Surg, Div Plast & Reconstruct Surg, Stanford, CA 94305 USA.
C3 Stanford University; Stanford University; Stanford University
RP Chang, ALS (通讯作者)，Stanford Univ, Sch Med, Dept Dermatol, 450 Broadway,Pavil C, Redwood City, CA 94063 USA.
EM alschang@stanford.edu
RI ; Gorell, Emily/AAF-4966-2021
OI Chang, Anne Lynn/0000-0002-2869-2147; Gorell, Emily/0000-0002-2813-3089
FU Spiracur TradeMark Inc.
FX This work was supported by a research grant from Spiracur (TM) Inc.
CR Abbade LPF, 2005, INT J DERMATOL, V44, P989, DOI 10.1111/j.1365-4632.2004.02276.x
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   Malli Suzanne, KEEP CLOSE EYE VACUU
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   US Food & Drug Administration, ADV PAT SER COMPL NE
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NR 17
TC 13
Z9 16
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2010
VL 22
IS 9
BP 230
EP 236
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 697QZ
UT WOS:000285531700007
PM 25901554
DA 2026-07-24
ER
PT J
AU Kim, BS
   Choi, WJ
   Baek, MK
   Kim, YS
   Lee, JW
AF Kim, Bom Soo
   Choi, Woo Jin
   Baek, Mi Kyung
   Kim, Yong Sang
   Lee, Jin Woo
TI Limb Salvage In Severe Diabetic Foot Infection
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE Diabetic Foot; Infection; Amputation; Limb Salvage; Negative Pressure
   Wound Therapy
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; AMPUTATION; ULCERS;
   RISK; MULTICENTER; VALIDATION
AB Background: The purpose of our study was to determine the efficacy of a management algorithm that includes negative pressure wound therapy (NPWT) in diabetic feet with limb-threatening infection. Materials and Methods: Forty-five septic diabetic feet were treated with NPWT between 2006 and 2008. After emergent abscess evacuation, early vascular intervention was performed if necessary. Debridement, with or without partial foot amputation, was followed by NPWT. Wound progress was measured using a digital scanner. A limb was considered salvaged if complete healing was achieved without any or with minor amputation through or below the ankle. The mean followup after complete wound healing was 17 (range, 6 to 35) months. Results: Thirty-two cases (71%) were infected with two or more organisms. Negative pressure wound therapy was applied for 26.2 +/- 14.3 days. The median time to achieve more than 75% wound area granulation was 23 (range, 4 to 55) days and 104 (range, 38 to 255) days to complete wound healing. Successful limb salvage was achieved in 44 cases (98%); 14 (31%) without any amputation and 30 (67%) with partial foot amputations. Total number of operations per limb was 2.4 +/- 1.3. One case of repeated infection and necrosis was managed with a transtibial amputation. There were no complications associated with NPWT. Conclusion: This study provides the outcome of a management algorithm which includes NPWT in salvaging severely infected diabetic feet. With emergent evacuation of abscess, early vascular intervention and appropriate debridement, NPWT can be a useful adjunct to the management of limb-threatening diabetic foot infections.
C1 [Lee, Jin Woo] Yonsei Univ, Coll Med, Dept Orthopaed Surg, Seoul 120752, South Korea.
C3 Yonsei University; Yonsei University Health System
RP Lee, JW (通讯作者)，Yonsei Univ, Coll Med, Dept Orthopaed Surg, 250 Seongsan No, Seoul 120752, South Korea.
EM ljwos@yuhs.ac
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NR 23
TC 19
Z9 24
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD JAN
PY 2011
VL 32
IS 1
BP 31
EP 37
DI 10.3113/FAI.2011.0031
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 703NR
UT WOS:000285986000006
PM 21288432
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Orgill, DP
   Bayer, LR
AF Orgill, Dennis P.
   Bayer, Lauren R.
TI Update on Negative-Pressure Wound Therapy
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED-CLOSURE; SUBATMOSPHERIC PRESSURE; STERNAL WOUNDS;
   SKIN-GRAFTS; BLOOD-FLOW; MANAGEMENT; FOOT; DEBRIDEMENT; INFECTIONS;
   ULCERS
AB Background: Over the last 15 years, negative-pressure wound therapy has become commonly used for treatment of a wide variety of complex wounds. There are now several systems marketed, and additional products will be available in the near future. Many clinicians have noted a dramatic response when negative-pressure wound therapy technology has been used, prompting a number of scientific investigations related to its mechanism of action and clinical trials determining its efficacy.
   Methods: The peer-reviewed literature within the past 5 years was reviewed, using an evidence-based approach.
   Results: Negative-pressure wound therapy works through mechanisms that include fluid removal, drawing the wound together, microdeformation, and moist wound healing. Several randomized clinical trials support the use of negative-pressure wound therapy in certain wound types. Serious complications, including bleeding and infection, have recently been reported by the U.S. Food and Drug Administration in a small number of patients.
   Conclusions: Negative-pressure wound therapy has dramatically changed the way complex wounds are treated. The rapid introduction of this technology has occurred faster than large-scale randomized controlled studies or registry studies have been conducted. Further clinical studies and basic science studies will help surgeons to better understand the evidence and use this technology in the future. (Plast. Reconstr. Surg. 127 (Suppl.): 105S, 2011.)
C1 [Orgill, Dennis P.; Bayer, Lauren R.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Orgill, DP (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
FU Kinetic Concepts Incorporated (KCI), San Antonio, Texas
FX Dr. Orgill is a principal investigator on research grants to the Brigham
   and Women's Hospital by Kinetic Concepts Incorporated (KCI), San
   Antonio, Texas, and is also an expert witness for litigation proceedings
   for KCI. Ms. Bayer has no financial interest in any of the products or
   devices mentioned in this article.
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NR 66
TC 114
Z9 146
U1 2
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2011
VL 127
IS 1
SU S
BP 105S
EP 115S
DI 10.1097/PRS.0b013e318200a427
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 705IP
UT WOS:000286122400016
PM 21200280
DA 2026-07-24
ER
PT J
AU Couch, KS
   Stojadinovic, A
AF Couch, Kara S.
   Stojadinovic, Alexander
TI Negative-Pressure Wound Therapy in the Military: Lessons Learned
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; IRRIGATION; MANAGEMENT; BLOOD; MODEL;
   EXPERIENCE; INJURIES; SYSTEM; SALINE; WATER
AB The utilization of negative pressure for medicinal purposes dates back to 600 BC. The U.S. military has been engaged in continuous overseas combat operations since 2001. Negative-pressure wound therapy has been in use in the treatment of casualties from these operations since 2004. It represents a new standard of practice in combat wound care; it promotes granulation tissue formation and creates mechanical forces supporting wound contraction, facilitating definitive wound closure. This article describes (1) the use of negative-pressure wound therapy in combat casualty care, (2) inherent challenges of its use in theater of operations and across the echelons of care, (3) modifications of this wound therapy to meet military-specific needs, and (4) future directions with this novel wound care modality. (Plast. Reconstr. Sing 127 (Suppl.): 117S, 2011.)
C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Complex Wound & Limb Salvage Ctr, Washington, DC 20307 USA.
   Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC 20307 USA.
C3 Walter Reed National Military Medical Center; United States Department
   of Defense; United States Army; United States Department of Defense;
   United States Army; Walter Reed National Military Medical Center
RP Stojadinovic, A (通讯作者)，Walter Reed Army Med Ctr, Dept Surg, Complex Wound & Limb Salvage Ctr, 6900 Georgia Ave,Room 5C27A NW, Washington, DC 20307 USA.
EM alexander.stojadinovic@amedd.army.mil
OI Stojadinovic, Alexander/0000-0002-2829-8967
FU Combat Wound Initiative Program, Washington, D.C.
FX This clinical research effort was supported, in part, by the Combat
   Wound Initiative Program, Washington, D.C.
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   US SERVICE MEMBER CA
   US MARKETS CURRENT E
NR 36
TC 24
Z9 30
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2011
VL 127
IS 1
SU S
BP 117S
EP 130S
DI 10.1097/PRS.0b013e3181fd344e
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 705IP
UT WOS:000286122400018
PM 21200282
DA 2026-07-24
ER
PT J
AU Janis, JE
   Kwon, RK
   Attinger, CE
AF Janis, Jeffrey E.
   Kwon, Robert K.
   Attinger, Christopher E.
TI The New Reconstructive Ladder: Modifications to the Traditional Model
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ARTIFICIAL DERMIS; WOUND THERAPY; INTEGRA;
   MANAGEMENT; FLAPS; STATE
AB The traditional reconstructive ladder has withstood the test of time, serving as a thought paradigm to guide surgeons in choosing their method of wound closure for an assortment of defects. Advances in anatomical understanding and technological innovations have improved our ability to achieve definitive closure in a wide variety of patients. In this article, the older construct is updated to reflect the use of negative-pressure wound therapy and dermal matrices. Perforator flap concepts are also discussed in terms of their inclusion as a rung on the ladder. (Plast. Reconstr. Surg. 127 (Suppl.): 205S, 2011.)
C1 [Janis, Jeffrey E.] Univ Texas SW Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
   Georgetown Univ, Med Ctr, Dept Plast Surg, Washington, DC 20007 USA.
   Georgetown Univ, Med Ctr, Dept Orthoped Surg, Washington, DC 20007 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; Georgetown University; Georgetown University
RP Janis, JE (通讯作者)，Univ Texas SW Med Ctr Dallas, Dept Plast Surg, 1801 Inwood Rd, Dallas, TX 75390 USA.
EM jeffrey.janis@utsouthwestern.edu
RI Janis, Jeffrey/W-6760-2019
OI Janis, Jeffrey/0000-0001-6103-4798
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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NR 29
TC 196
Z9 219
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2011
VL 127
IS 1
SU S
BP 205S
EP 212S
DI 10.1097/PRS.0b013e318201271c
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 705IP
UT WOS:000286122400028
PM 21200292
DA 2026-07-24
ER
PT J
AU Ennker, IC
   Bär, AK
   Florath, I
   Ennker, J
   Vogt, PM
AF Ennker, I. C.
   Baer, A. K.
   Florath, I.
   Ennker, J.
   Vogt, P. M.
TI In Search of a Standardized Treatment for Poststernotomy Mediastinitis
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE sternotomy; mediastinitis; vacuum therapy; sternal stabilization;
   therapeutic algorithm
ID VACUUM-ASSISTED CLOSURE; WOUND INFECTIONS; STERNOTOMY; TRANSPOSITION;
   EXPERIENCE; MANAGEMENT; ARTERY; FLAP
AB Poststernotomy mediastinitis following median sternotomy procedures such as open heart surgery is a rare complication which nevertheless has a mortality rate of up to 50%. Several treatment options are currently available; however, none of them are standardized. Based on the experience gained from open heart surgery performed at the MediClin Heart Institute Lahr/Baden, a therapeutic algorithm was developed. The treatment steps consist of repeated radical surgical debridement, sternal restabilization, vacuum-assisted closure therapy (VAC) as well as a surgical reconstruction via M. pectoralis plasty (MPP). This approach had a 30-day mortality of 0% and a hospital mortality of 10.4%. The approach proved to be safe and advantageous for specific patient groups operated on at the MediClin Heart Institute Lahr/Baden.
C1 [Ennker, I. C.; Baer, A. K.; Florath, I.; Ennker, J.] MediClin Heart Inst Lahr Baden, D-77933 Lahr, Germany.
   [Ennker, I. C.; Vogt, P. M.] Hannover Med Sch, Clin Plast Chiroplast & Restorat Surg, D-3000 Hannover, Germany.
C3 Hannover Medical School
RP Bär, AK (通讯作者)，MediClin Heart Inst Lahr Baden, Hohbergweg 2, D-77933 Lahr, Germany.
EM antonia.baer@mediclin.de
RI Vogt, Peter/AAL-1332-2020
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NR 20
TC 15
Z9 17
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD FEB
PY 2011
VL 59
IS 1
BP 15
EP 20
DI 10.1055/s-0030-1250335
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 707TE
UT WOS:000286310200003
PM 21243566
DA 2026-07-24
ER
PT J
AU Erba, P
   Ogawa, R
   Ackermann, M
   Adini, A
   Miele, LF
   Dastouri, P
   Helm, D
   Mentzer, SJ
   D'Amato, RJ
   Murphy, GF
   Konerding, MA
   Orgill, DP
AF Erba, Paolo
   Ogawa, Rei
   Ackermann, Maximilian
   Adini, Avner
   Miele, Lino F.
   Dastouri, Pouya
   Helm, Doug
   Mentzer, Steven J.
   D'Amato, Robert J.
   Murphy, George F.
   Konerding, Moritz A.
   Orgill, Dennis P.
TI Angiogenesis in Wounds Treated by Microdeformational Wound Therapy
SO ANNALS OF SURGERY
LA English
DT Article
ID ENDOTHELIAL GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; TOPICAL
   NEGATIVE-PRESSURE; FACTOR VEGF; IN-VITRO; EXPRESSION; HYPOXIA; OXYGEN;
   CANCER; TISSUE
AB Background: Mechanical forces play an important role in tissue neovascularization and are a constituent part of modern wound therapies. The mechanisms by which vacuum assisted closure (VAC) modulates wound angiogenesis are still largely unknown.
   Objective: To investigate how VAC treatment affects wound hypoxia and related profiles of angiogenic factors as well as to identify the anatomical characteristics of the resultant, newly formed vessels.
   Methods: Wound neovascularization was evaluated by morphometric analysis of CD31-stained wound cross-sections as well as by corrosion casting analysis. Wound hypoxia and mRNA expression of HIF-1 alpha and associated angiogenic factors were evaluated by pimonidazole hydrochloride staining and quantitative reverse transcription-polymerase chain reaction (RT-PCR), respectively. Vascular endothelial growth factor (VEGF) protein levels were determined by western blot analysis.
   Results: VAC-treated wounds were characterized by the formation of elongated vessels aligned in parallel and consistent with physiologically function, compared to occlusive dressing control wounds that showed formation of tortuous, disoriented vessels. Moreover, VAC-treated wounds displayed a well-oxygenated wound bed, with hypoxia limited to the direct proximity of the VAC-foam interface, where higher VEGF levels were found. By contrast, occlusive dressing control wounds showed generalized hypoxia, with associated accumulation of HIF-1 alpha and related angiogenic factors.
   Conclusions: The combination of established gradients of hypoxia and VEGF expression along with mechanical forces exerted by VAC therapy was associated with the formation of more physiological blood vessels compared to occlusive dressing control wounds. These morphological changes are likely a necessary condition for better wound healing.
C1 [Erba, Paolo] Univ Lausanne Hosp, Dept Plast Reconstruct & Aesthet Surg, CH-1011 Lausanne, Switzerland.
   [Erba, Paolo; Ogawa, Rei; Dastouri, Pouya; Helm, Doug; Orgill, Dennis P.] Harvard Univ, Brigham & Womens Hosp, Tissue Engn & Wound Healing Lab, Div Plast Surg,Med Sch, Boston, MA 02115 USA.
   [Ogawa, Rei] Nippon Med Sch, Dept Plast Reconstruct & Aesthet Surg, Tokyo 113, Japan.
   [Ackermann, Maximilian; Konerding, Moritz A.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Funct & Clin Anat, Mainz, Germany.
   [Adini, Avner; D'Amato, Robert J.] Harvard Univ, Dept Surg, Vasc Biol Program,Childrens Hosp Boston, Sch Med, Boston, MA 02115 USA.
   [Miele, Lino F.; Mentzer, Steven J.] Harvard Univ, Sch Med, Lab Adapt & Regenerat Biol, Dept Surg, Boston, MA 02115 USA.
   [Murphy, George F.] Harvard Univ, Sch Med, Dept Pathol, Brigham & Womens Hosp, Boston, MA 02115 USA.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Nippon Medical School;
   Johannes Gutenberg University of Mainz; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Boston Children's
   Hospital; Harvard University; Harvard Medical School; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard Medical School
RP Erba, P (通讯作者)，Univ Lausanne Hosp, Dept Plast Reconstruct & Aesthet Surg, CH-1011 Lausanne, Switzerland.
EM erbapaolo@hotmail.com
RI Orgill, Dennis/H-7596-2019; Adini, Avner/AAD-6141-2022
OI Orgill, Dennis/0000-0002-8279-7310; 
FU Kinetics Concepts, Inc.; Department of Surgery at Brigham and Women's
   Hospital
FX Dr. Orgill is an expert witness for Akin, Gump, Strauss, Hauer and Feld,
   LLP that represents Kinetics Concepts, Inc. Dr. Orgill is a principal
   investigator for a research grant to Brigham and Women's Hospital funded
   by Kinetics Concepts, Inc.The study was funded by the Department of
   Surgery at Brigham and Women's Hospital.
CR [Anonymous], HYPERBARIC SURG PERI
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NR 61
TC 160
Z9 197
U1 0
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD FEB
PY 2011
VL 253
IS 2
BP 402
EP 409
DI 10.1097/SLA.0b013e31820563a8
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 708OV
UT WOS:000286374400032
PM 21217515
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Collinge, C
   Reddix, R
AF Collinge, Cory
   Reddix, Robert
TI The Incidence of Wound Complications Related to Negative Pressure Wound
   Therapy Power Outage and Interruption of Treatment in Orthopaedic Trauma
   Patients
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article; Proceedings Paper
CT 51st Annual Meeting of the Society-of-Military-Orthopedic-Surgeons
   (SOMOS)
CY DEC 08, 2009
CL Honolulu, HI
SP Soc Mil Orthoped Surg
DE wound VAC; complications; wound; wound complications; negative pressure;
   infection
ID OPEN CELL FOAM; FRACTURES
AB Objective: Negative pressure wound therapy (NPWT) using the Vacuum Assisted Closure system is an invaluable tool for use on patients with complex limb and soft tissue problems. Recently, the manufacturer (Kinetic Concepts, Inc, San Antonio, TX) made significant modifications to the NPWT platform, including computer software, battery, alarming systems, electric cord and plug apparatus, and others. Since these modifications, we have seen several cases in which the NPWT device has powered off resulting in an unrecognized interruption of therapy. We sought to evaluate the conditions and clinical effects, if any, to orthopaedic trauma patients who experienced an interruption of NPWT therapy when the device powers off.
   Design: Retrospective study of consecutive patients.
   Setting: Two neighboring regional trauma centers.
   Patients: One hundred twenty-three consecutive orthopaedic trauma patients treated with NPWT by two orthopaedic trauma surgeons between May and November 2008.
   Main Outcome Measurements: Patient/injury, treatment, and perioperative clinical outcomes data (with emphasis on wound complications such as infection, graft loss, and unscheduled surgery) were collected from medical records and wound care databases.
   Results: Twelve patients (10%) had problems with the NPWT device powering off causing an unrecognized interruption of therapy. Eleven patients underwent early (less than 6 hours) wound debridement and reapplication of NPWT after detection, of which nine required unplanned surgery. Seven of the 12 patients recognized as having failed NPWT of this type ultimately experienced wound complications, including five deep infections and both patients being treated with an Integra graft (loss of graft).
   Conclusions: We have seen substantial problems in orthopaedic trauma patients treated with the NPWT, in which the device has powered off resulting in an unrecognized interruption of therapy. This has resulted in atypically unhealthy-appearing wounds, unplanned surgeries for debridement, and most importantly, an increased incidence of wound complications, including infection and graft loss (P < 0.05).
C1 [Collinge, Cory] Harris Methodist Ft Worth Hosp, Dept Orthoped Trauma, Ft Worth, TX USA.
   [Reddix, Robert] Univ N Texas, Orthopaed Training Program, Ft Worth Affiliated Hosp, Dept Orthoped Trauma,Dept Orthoped Surg,John Pete, Ft Worth, TX USA.
C3 University of North Texas System; University of North Texas Health
   Science Center
RP Collinge, C (通讯作者)，800 5th Ave,Suite 500, Ft Worth, TX 76104 USA.
EM ccollinge@msn.com
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   Jacobs S, 2009, J PLAST RECONSTR AES, V62, P1331, DOI 10.1016/j.bjps.2008.03.024
   LALLISS SJ, 2007, ANN M ORTH TRAUM ASS
   Leijnen Michiel, 2008, Int J Low Extrem Wounds, V7, P51, DOI 10.1177/1534734607313699
   MURFF HJ, 2001, MAKING HLTH CARE SAF
   Powell ET, 2008, J ORTHOP TRAUMA, V22, pS138, DOI 10.1097/BOT.0b013e318188e27d
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   Schlatterer D, 2005, WOUNDS, p27S
   Schlatterer D, 2008, J ORTHOP TRAUMA, V22, pS152, DOI 10.1097/BOT.0b013e318188e2d7
   Simons D, 1997, PROCEEDINGS OF THE HUMAN FACTORS AND ERGONOMICS SOCIETY 41ST ANNUAL MEETING, 1997, VOLS 1 AND 2, P777
   STEVENS S, 1981, SOUND HEARING
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   Webb LX, 2008, J ORTHOP TRAUMA, V22, pS135, DOI 10.1097/BOT.0b013e31818956ce
   Webb Lawrence X, 2006, J Am Acad Orthop Surg, V14, pS82
   2007, EXTREMITY WAR INJURI
   2003, NATL PATIENT SAFETY
NR 20
TC 34
Z9 40
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD FEB
PY 2011
VL 25
IS 2
BP 96
EP 100
DI 10.1097/BOT.0b013e3181de0134
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics; Sport Sciences
GA 708PA
UT WOS:000286375000011
PM 21245712
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Lindstedt, S
   Ingemansson, R
AF Malmsjo, Malin
   Lindstedt, Sandra
   Ingemansson, Richard
TI Effects on heart pumping function when using foam and gauze for negative
   pressure wound therapy of sternotomy wounds
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; AGGRESSIVE
   MANAGEMENT; EARLY INTERVENTION; INCISION; SURGERY; RUPTURE
AB Background: Negative pressure wound therapy (NPWT) has remarkable effects on the healing of poststernotomy mediastinitis. Foam is presently the material of choice for NPWT in this indication. There is now increasing interest in using gauze, as this has proven successful in the treatment of peripheral wounds. It is important to determine the effects of NPWT using gauze on heart pumping function before it can be used for deep sternotomy wounds. The aim was to examine the effects of NPWT when using gauze and foam on the heart pumping function during the treatment of a sternotomy wound.
   Methods: Eight pigs underwent median sternotomy followed by NPWT at -40, -70, -120 and -160 mmHg, using foam or gauze. The heart frequency, cardiac output, mean systemic arterial pressure, mean pulmonary artery pressure, central venous pressure and left atrial pressure were recorded.
   Results: Cardiac output was not affected by NPWT using gauze or foam. Heart frequency decreased during NPWT when using foam, but not gauze. Treatment with foam also lowered the central venous pressure and the left atrial pressure, while gauze had no such effects. Mean systemic arterial pressure, mean pulmonary artery pressure and systemic vascular resistance were not affected by NPWT. Similar haemodynamic effects were observed at all levels of negative pressure studied.
   Conclusions: NPWT using foam results in decreased heart frequency and lower right and left atrial filling pressures. The use of gauze in NPWT did not affect the haemodynamic parameters studied. Gauze may thus provide an alternative to foam for NPWT of sternotomy wounds.
C1 [Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden.
   [Lindstedt, Sandra; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473
FU Ake-Wieberg Foundation; Magn Bergvall Foundation; Swedish Medical
   Association; Royal Physiographic Society in Lund; Crafoord Foundation;
   Swedish Heart-Lung Foundation; Swedish Hypertension Society; Smith &
   Nephew Wound Management
FX This study was funded by Ake-Wieberg Foundation, the Magn Bergvall
   Foundation, the Swedish Medical Association, the Royal Physiographic
   Society in Lund, the Crafoord Foundation, the Swedish Heart-Lung
   Foundation, the Swedish Hypertension Society and Smith & Nephew Wound
   Management.
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   BORGQUIST O, 2009, WOUNDS
   Campbell PE, 2006, J WOUND OSTOMY CONT, V33, P176, DOI 10.1097/00152192-200603000-00014
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   Miller MS, 2005, OSTOMY WOUND MANAG, V51, P44
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   Steigelman MB, 2009, ANN THORAC SURG, V88, P1277, DOI 10.1016/j.athoracsur.2009.06.027
NR 22
TC 1
Z9 2
U1 0
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD JAN 13
PY 2011
VL 6
AR 5
DI 10.1186/1749-8090-6-5
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 714TH
UT WOS:000286831400001
PM 21232105
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zanus, G
   Boetto, R
   D'Amico, F
   Gringeri, E
   Vitale, A
   Carraro, A
   Bassi, D
   Scopelliti, M
   Bonsignore, P
   Burra, P
   Angeli, P
   Feltracco, P
   Cillo, U
AF Zanus, Giacomo
   Boetto, Riccardo
   D'Amico, Francesco
   Gringeri, Enrico
   Vitale, Alessandro
   Carraro, Amedeo
   Bassi, Domenico
   Scopelliti, Michele
   Bonsignore, Pasquale
   Burra, Patrizia
   Angeli, Paolo
   Feltracco, Paolo
   Cillo, Umberto
TI A novel approach to severe acute pancreatitis in sequential liver-kidney
   transplantation: the first report on the application of VAC therapy
SO TRANSPLANT INTERNATIONAL
LA English
DT Article
DE abdominal sepsis; complications; kidney transplantation; liver
   transplantation; pancreatitis; vacuum-assisted closure therapy
ID ASSISTED CLOSURE; BILIARY STRICTURES; SEVERE PERITONITIS; MANAGEMENT;
   RECIPIENTS; FAILURE; WOUNDS
AB P>This work is the first report of vacuum-assisted closure (VAC) therapy applied as a life-saving surgical treatment for severe acute pancreatitis occurring in a sequential liver- and kidney-transplanted patient who had percutaneous biliary drainage for obstructive "late-onset" jaundice. Surgical exploration with necrosectomy and sequential laparotomies was performed because of increasing intra-abdominal pressure with hemodynamic instability and intra-abdominal multidrug-resistant sepsis, with increasingly difficult abdominal closure. Repeated laparotomies with VAC therapy (applying a continuous negative abdominal pressure) enabled a progressive, successful abdominal decompression, with the clearance of infection and definitive abdominal wound closure. The application of a negative pressure is a novel approach to severe abdominal sepsis and laparostomy management with a view to preventing compartment syndrome and fatal sepsis, and it can lead to complete abdominal wound closure.
C1 [Zanus, Giacomo; Boetto, Riccardo; D'Amico, Francesco; Gringeri, Enrico; Vitale, Alessandro; Carraro, Amedeo; Bassi, Domenico; Scopelliti, Michele; Bonsignore, Pasquale; Cillo, Umberto] Azienda Univ Padova, Hepatobiliary Surg & Liver Transplant Unit, I-35139 Padua, Italy.
   [Feltracco, Paolo] ICU, Padua, Italy.
C3 University of Padua; Azienda Ospedaliera - Universita di Padova
RP Boetto, R (通讯作者)，Azienda Univ Padova, Hepatobiliary Surg & Liver Transplant Unit, Via Concariola N 2, I-35139 Padua, Italy.
EM rboetto@hotmail.com
RI D'Amico, Francesco/AFL-3751-2022; Carraro, Amedeo/AAB-9001-2019;
   GRINGERI, ENRICO/AAB-9315-2019; Cillo, Umberto/AAC-2591-2019;
   Bonsignore, Pasquale/I-7898-2018; Vitale, Alessandro/AAA-9182-2021;
   Burra, Patrizia/AAB-2448-2019; Angeli, Paolo/A-9759-2015; Zanus,
   Giacomo/AIB-1093-2022
OI D'Amico, Francesco/0000-0001-6915-9755; Carraro,
   Amedeo/0000-0001-6449-4597; Scopelliti, Michele/0000-0001-9965-1281;
   GRINGERI, ENRICO/0000-0002-3459-7306; Cillo,
   Umberto/0000-0002-2310-0245; Bonsignore, Pasquale/0000-0002-3118-5453;
   Vitale, Alessandro/0000-0002-4548-8308; Burra,
   Patrizia/0000-0002-8791-191X; 
CR Al-Bahrani A Z, 2006, HPB (Oxford), V8, P446, DOI 10.1080/13651820600917294
   Amin AI, 2009, WORLD J GASTROENTERO, V15, P3394, DOI 10.3748/wjg.15.3394
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   CARMAGO C, 1995, J AM COLL SURGEONS, V181, P249
   de Laet I E, 2007, Med Intensiva, V31, P88
   Hadaya K, 2009, TRANSPL INT, V22, P242, DOI 10.1111/j.1432-2277.2008.00775.x
   Horwood J, 2009, ANN ROY COLL SURG, V91, P681, DOI 10.1308/003588409X12486167520993
   KROKOS NV, 1995, TRANSPLANT INT, V8, P1
   Lochan R, 2009, EXP CLIN TRANSPLANT, V7, P110
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   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
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   Zoepf T, 2006, LIVER TRANSPLANT, V12, P88, DOI 10.1002/lt.20548
NR 18
TC 3
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0934-0874
EI 1432-2277
J9 TRANSPL INT
JI Transpl. Int.
PD MAR
PY 2011
VL 24
IS 3
BP e23
EP e27
DI 10.1111/j.1432-2277.2010.01198.x
PG 5
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA 714WC
UT WOS:000286838700002
PM 21129043
DA 2026-07-24
ER
PT J
AU Borgquist, O
   Ingemansson, R
   Malmsjö, M
AF Borgquist, Ola
   Ingemansson, Richard
   Malmsjo, Malin
TI The Influence of Low and High Pressure Levels during Negative-Pressure
   Wound Therapy on Wound Contraction and Fluid Evacuation
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; METALLOPROTEINASES; EXPRESSION; MARKERS; ULCERS
AB Background: Negative-pressure wound therapy promotes healing by drainage of excessive fluid and debris and by mechanical deformation of the wound. The most commonly used negative pressure, -125 mmHg, may cause pain and ischemia, and the pressure often needs to be reduced. The aim of the present study was to examine wound contraction and fluid removal at different levels of negative pressure.
   Methods: Peripheral wounds were created in 70-kg pigs. The immediate effects of negative-pressure wound therapy (-10 to -175 mmHg) on wound contraction and fluid removal were studied in eight pigs. The long-term effects on wound contraction were studied in eight additional pigs during 72 hours of negative-pressure wound therapy at -75 mmHg.
   Results: Wound contraction and fluid removal increased gradually with increasing levels of negative pressure until reaching a steady state. Maximum wound contraction was observed at -75 mmHg. When negative-pressure wound therapy was discontinued, after 72 hours of therapy, the wound surface area was smaller than before therapy. Maximum wound fluid removal was observed at -125 mmHg.
   Conclusions: Negative-pressure wound therapy facilitates drainage of wound fluid and exudates and results in mechanical deformation of the wound edge tissue, which is known to stimulate granulation tissue formation. Maximum wound contraction is achieved already at -75 mmHg, and this may be a suitable pressure for most wounds. In wounds with large volumes of exudate, higher pressure levels may be needed for the initial treatment period. (Plast. Reconstr. Surg. 127: 551, 2011.)
C1 Lund Univ, Dept Ophthalmol, Lund, Sweden.
   Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   Skane Univ Hosp, Lund, Sweden.
C3 Lund University; Lund University; Lund University; Skane University
   Hospital
RP Malmsjö, M (通讯作者)，Vasc Res BMC A13,Solvegatan 17, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Borgquist, Ola/AAO-6451-2020
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599; 
FU Prospera; Swedish Medical Research Council; Lund University Faculty of
   Medicine; Swedish Government Grant for Clinical Research; Lund
   University Hospital Research Grants; Swedish Medical Association; Royal
   Physiographic Society in Lund; Ake Wiberg Foundation; Anders Otto Sward
   Foundation/Ulrika Eklund Foundation; Magn Bergvall Foundation; Crafoord
   Foundation; Anna-Lisa and Sven-Erik Nilsson Foundation; Jeansson
   Foundation; Swedish Heart-Lung Foundation; Anna och Edvin Berger's
   Foundation; Marta Lundqvist Foundation; Lars Hiertas Memory Foundation
FX The study was supported by Prospera, the Swedish Medical Research
   Council, Lund University Faculty of Medicine, the Swedish Government
   Grant for Clinical Research, Lund University Hospital Research Grants,
   the Swedish Medical Association, the Royal Physiographic Society in
   Lund, the Ake Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika
   Eklund Foundation, the Magn Bergvall Foundation, the Crafoord
   Foundation, the Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeansson
   Foundation, the Swedish Heart-Lung Foundation, Anna och Edvin Berger's
   Foundation, the Marta Lundqvist Foundation, and the Lars Hiertas Memory
   Foundation. The authors thank Bodil Gesslein and Gisela Hakansson for
   contributing to the experimental work.
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NR 35
TC 95
Z9 133
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD FEB
PY 2011
VL 127
IS 2
BP 551
EP 559
DI 10.1097/PRS.0b013e3181fed52a
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 715XJ
UT WOS:000286928100009
PM 20966819
DA 2026-07-24
ER
PT J
AU Tan, Y
   Wang, X
   Li, H
   Zheng, Q
   Li, J
   Feng, G
   Pan, ZJ
AF Tan, Y.
   Wang, X.
   Li, H.
   Zheng, Q.
   Li, J.
   Feng, G.
   Pan, Zhijun
TI The clinical efficacy of the vacuum-assisted closure therapy in the
   management of adult osteomyelitis
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE Vacuum-assisted closure; Osteomyelitis; Debridement; Granulation tissue
ID SOFT-TISSUE INJURIES; NEGATIVE-PRESSURE; WOUND THERAPY; INFECTION;
   FRACTURES; DIAGNOSIS; TRIAL; STATE
AB Vacuum-assisted closure (VAC) therapy is a sophisticated development of a standard surgical procedure. The purpose of this study is to evaluate the clinical efficacy of managing adult osteomyelitis with VAC therapy.
   We included a total of 68 patients that developed osteomyelitis with Cierny-Mader types 2, 3 and 4, and required open wound management between March 2005 and February 2009. In this study, 35 of these patients were treated by VAC therapy and the other 33 by conventional wound management. The patients were well compared with type, debridement times, wounds coverage, bacteriology and recurrence.
   Of the study, the patients treated by VAC therapy had a significantly reduced recurrence (1 vs. 7 wounds, P < 0.05), decreased rate of further autodermoplasty or flap surgery (17 vs. 26 wounds, P < 0.05), and increased cases of bacterial species cultures to negative (29 vs. 15 wounds, P < 0.05), debridement times and type were similar between the two groups.
   VAC therapy represents a good clinical efficacy in treating osteomyelitis; it can promote the granulation tissue formation, bacterial clearance, and reduce the needs for tissue transfer and muscle flaps in patients. In addition, it could be used as an adjuvant for the eradication of osteomyelitis and improving soft-tissue management, it may be more suitable for treating osteomyelitis with soft-tissue problems.
C1 [Tan, Y.; Wang, X.; Li, H.; Zheng, Q.; Li, J.; Feng, G.; Pan, Zhijun] Zhejiang Univ, Sch Med, Dept Orthopaed Surg, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Pan, ZJ (通讯作者)，Zhejiang Univ, Sch Med, Dept Orthopaed Surg, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China.
EM drtany@hotmail.com
RI Pan, Zhijun/AAD-6547-2022
FU Medicine Health Sciences Fund of Zhejiang [2008A095]; Natural Science
   Foundation of Zhejiang [Y208034, Y2100111]
FX This study was supported by the Medicine Health Sciences Fund of
   Zhejiang (2008A095) and the Natural Science Foundation of Zhejiang
   (Y208034, Y2100111).
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NR 30
TC 27
Z9 38
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD FEB
PY 2011
VL 131
IS 2
BP 255
EP 259
DI 10.1007/s00402-010-1197-x
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 716OQ
UT WOS:000286983700017
PM 21181410
DA 2026-07-24
ER
PT J
AU Campbell, AM
   Kuhn, WP
   Barker, P
AF Campbell, A. M.
   Kuhn, W. P.
   Barker, P.
TI Vacuum-assisted closure of the open abdomen in a resource-limited
   setting
SO SOUTH AFRICAN JOURNAL OF SURGERY
LA English
DT Article
ID PACK TECHNIQUE; WOUNDS; TRAUMA
AB Aim. We describe our experience of developing a modified vacuum-assisted closure (VAC) dressing for open abdomens.
   Background. We see a high volume of trauma in our department. Massive delays in presentation of patients with acute abdomen are common. Closure at initial laparotomy is not possible in many cases, either because the patient has or will develop abdominal compartment syndrome, or because several re-look laparotomies will be required. A significant proportion of our patients who have undergone laparotomy therefore spend some of their stay in hospital with an open abdomen. The management of these patients is particularly labour intensive for nursing staff. The Opsite sandwich or Bogota bag invariably leaks, and sometimes needs changing daily. If a patient also has a temporary ileostomy, application can be difficult. The commercial VAC dressing is an improvement on the Opsite sandwich, but is prohibitively expensive. Financial constraints and the volume of abdominal trauma and sepsis we see mean that commercial VAC dressings for laparostomy are not affordable in our setting.
   Methods/results: We describe our adapted VAC dressing. It is inexpensive and easy to apply, has made a big difference in the nursing of patients with an open abdomen, and has enabled us to increase the rate of delayed primary closure (i.e. we have reduced the rate of ventral hernia).
   Conclusion. The modified VAC dressing is now our department's method of choice for temporary abdominal closure.
C1 [Campbell, A. M.; Kuhn, W. P.; Barker, P.] Ngwelezane Hosp, Kwazulu Natal, South Korea.
RP Campbell, AM (通讯作者)，Ngwelezane Hosp, Kwazulu Natal, South Korea.
OI Campbell, Alison/0009-0005-5951-8028
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Fernandez L, 1996, J TRAUMA, V40, P258, DOI 10.1097/00005373-199602000-00014
   Garner GB, 2001, AM J SURG, V182, P630, DOI 10.1016/S0002-9610(01)00786-3
   Ghimenton F, 2000, BRIT J SURG, V87, P106, DOI 10.1046/j.1365-2168.2000.01337.x
   Lee JC, 2006, CURR OPIN CRIT CARE, V12, P346, DOI 10.1097/01.ccx.0000235213.63988.9a
   MOENG S, 2005, INT TRAUMA CARE  FAL, P185
   Moore EE, 1998, WORLD J SURG, V22, P1184, DOI 10.1007/s002689900542
   Navsaria PH, 2003, BRIT J SURG, V90, P718, DOI 10.1002/bjs.4101
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NR 9
TC 10
Z9 11
U1 0
U2 0
PU SA MEDICAL ASSOC
PI PRETORIA
PA BLOCK F CASTLE WALK CORPORATE PARK, NOSSOB STREET, ERASMUSKLOOF EXT3,
   PRETORIA, 0002, SOUTH AFRICA
SN 0038-2361
J9 S AFR J SURG
JI South Afr. J. Surg.
PD NOV
PY 2010
VL 48
IS 4
BP 114
EP 115
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 717AP
UT WOS:000287014900003
PM 21542399
DA 2026-07-24
ER
PT J
AU Powell, AGMT
   Crozier, JEM
   Hodgson, H
   Galloway, DJ
AF Powell, Arfon G. M. T.
   Crozier, Joseph E. M.
   Hodgson, Heather
   Galloway, David J.
TI A case of septicaemic anthrax in an intravenous drug user
SO BMC INFECTIOUS DISEASES
LA English
DT Article
ID INHALATIONAL ANTHRAX; HEROIN; BIOTERRORISM; INFECTION; SURVIVAL;
   OUTBREAK; GLASGOW; COHORT
AB Background: In 2000, Ringertz et al described the first case of systemic anthrax caused by injecting heroin contaminated with anthrax. In 2008, there were 574 drug related deaths in Scotland, of which 336 were associated with heroin and or morphine. We report a rare case of septicaemic anthrax caused by injecting heroin contaminated with anthrax in Scotland.
   Case Presentation: A 32 year old intravenous drug user (IVDU), presented with a 12 hour history of increasing purulent discharge from a chronic sinus in his left groin. He had a tachycardia, pyrexia, leukocytosis and an elevated C-reactive protein (CRP). He was treated with Vancomycin, Clindamycin, Ciprofloxacin, Gentamicin and Metronidazole. Blood cultures grew Bacillus anthracis within 24 hours of presentation. He had a computed tomography (CT) scan and magnetic resonance imagining (MRI) of his abdomen, pelvis and thighs performed. These showed inflammatory change relating to the iliopsoas and an area of necrosis in the adductor magnus. He underwent an exploration of his left thigh. This revealed chronically indurated subcutaneous tissues with no evidence of a collection or necrotic muscle. Treatment with Vancomycin, Ciprofloxacin and Clindamycin continued for 14 days. Negative Pressure Wound Therapy (NPWT) device was applied utilising the Venturi T wound sealing kit. Following 4 weeks of treatment, the wound dimensions had reduced by 77%.
   Conclusions: Although systemic anthrax infection is rare, it should be considered when faced with severe cutaneous infection in IVDU patients. This case shows that patients with significant bacteraemia may present with no signs of haemodynamic compromise. Prompt recognition and treatment with high dose IV antimicrobial therapy increases the likelihood of survival. The use of simple wound therapy adjuncts such as NPWT can give excellent wound healing results.
C1 [Powell, Arfon G. M. T.; Crozier, Joseph E. M.; Galloway, David J.] Gartnavel Royal Hosp, Dept Surg Gastroenterol, Glasgow, Lanark, Scotland.
C3 Gartnavel Royal Hospital
RP Powell, AGMT (通讯作者)，Gartnavel Royal Hosp, Dept Surg Gastroenterol, Glasgow, Lanark, Scotland.
EM arfonpowell@doctors.org.uk
RI Powell, Arfon/H-6794-2019
OI Powell, Arfon/0000-0002-3740-8275
CR [Anonymous], DRUG REL DEATHS SCOT
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NR 24
TC 23
Z9 26
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD JAN 20
PY 2011
VL 11
AR 21
DI 10.1186/1471-2334-11-21
PG 6
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 717ZA
UT WOS:000287086600001
PM 21251266
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lu, F
   Ogawa, R
   Nguyen, DT
   Chen, B
   Guo, DF
   Helm, DL
   Zhan, QA
   Murphy, GF
   Orgill, DP
AF Lu, Feng
   Ogawa, Rei
   Nguyen, Dinh T.
   Chen, Bin
   Guo, Danfeng
   Helm, Douglas L.
   Zhan, Qian
   Murphy, George F.
   Orgill, Dennis P.
TI Microdeformation of Three-Dimensional Cultured Fibroblasts Induces Gene
   Expression and Morphological Changes
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE vacuum-assisted closure (VAC); mechanotransduction; microdeformations;
   wound healing; fibroblast; collagen; smooth muscle actin; fibroblast
   growth factor; transforming growth factor; myofibroblast
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; PATHWAY
AB Background: Vacuum-assisted closure induces microdeformations of the wound surface and accelerates healing of complex wounds; however, a thorough understanding of the biology of cellular mechanotransduction is lacking. We hypothesized that fibroblast shape and function can be altered in an in vitro vacuum-assisted closure device.
   Methods: A 3-dimensional fibrin matrix with cultured murine fibroblasts and an intervening polyurethane foam was exposed to 125 mm Hg suction and compared with similar wells without suction. We measured fibroblast proliferation and morphology using fluorescence microscopy and gene expression change using real-time reverse-transcriptase polymerase chain reaction at 24, 48, and 72 hours.
   Results: Wells exposed to suction induced significant proliferation of fibroblasts and morphologic changes visible by larger, rounder, and notable dendrite-like branching and process extensions. Type 1 collagen alpha 1 (COL1A1), fibroblast growth factor 2 (FGF2, bFGF), and transforming growth factor beta 1 (TGF beta 1) were all up-regulated after 48 hours of exposure to suction. Smooth muscle actin alpha 2 (Acta2, alpha-SMA) was up-regulated after 72 hours.
   Conclusions: Microdeformations produced by the combination of polyurethane foam and suction are associated with increased fibroblast proliferation and up-regulation of gene expressions in fibroblasts.
C1 [Lu, Feng; Ogawa, Rei; Nguyen, Dinh T.; Chen, Bin; Guo, Danfeng; Helm, Douglas L.; Orgill, Dennis P.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
   [Lu, Feng] So Med Univ, Dept Plast & Reconstruct Surg, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China.
   [Ogawa, Rei] Nippon Med Sch, Dept Plast Reconstruct & Aesthet Surg, Tokyo 113, Japan.
   [Chen, Bin] Kunming Med Coll, Affiliated Hosp 2, Dept Burn & Plast Surg, Kunming, Peoples R China.
   [Guo, Danfeng] Cent Hosp Jian, Dept Plast Surg, Jian, Shandong, Peoples R China.
   [Zhan, Qian; Murphy, George F.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Program Dermatopathol,Dept Pathol, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Southern Medical University -
   China; Nippon Medical School; Kunming Medical University; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Orgill, DP (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI /AAG-3449-2019; Orgill, Dennis/H-7596-2019
OI Chen, Bin/0000-0002-7606-1382; Orgill, Dennis/0000-0002-8279-7310
FU KCI
FX Dennis P. Orgill, MD, PhD, is the principal investigator on research
   grants to Brigham and Women's Hospital by KCI, and is an expert witness
   for KCI, San Antonio, Texas. The bioreactor used in this study, suction
   apparatus, and foam were provided by KCI.
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NR 21
TC 70
Z9 83
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAR
PY 2011
VL 66
IS 3
BP 296
EP 300
DI 10.1097/SAP.0b013e3181ea1e9b
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 719UX
UT WOS:000287237800017
PM 21233699
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Runkel, N
   Krug, E
   Berg, L
   Lee, C
   Hudson, D
   Birke-Sorensen, H
   Depoorter, M
   Dunn, R
   Jeffery, S
   Duteille, F
   Bruhin, A
   Caravaggi, C
   Chariker, M
   Dowsett, C
   Ferreira, F
   Martínez, JMF
   Grudzien, G
   Ichioka, S
   Ingemansson, R
   Malmsjo, M
   Rome, P
   Vig, S
   Martin, R
   Smith, J
AF Runkel, N.
   Krug, E.
   Berg, L.
   Lee, C.
   Hudson, D.
   Birke-Sorensen, H.
   Depoorter, M.
   Dunn, R.
   Jeffery, S.
   Duteille, F.
   Bruhin, A.
   Caravaggi, C.
   Chariker, M.
   Dowsett, C.
   Ferreira, F.
   Francos Martinez, J. M.
   Grudzien, G.
   Ichioka, S.
   Ingemansson, R.
   Malmsjo, M.
   Rome, P.
   Vig, S.
   Martin, R.
   Smith, J.
CA Int Expert Panel Negative Pressure
TI Evidence-based recommendations for the use of Negative Pressure Wound
   Therapy in traumatic wounds and reconstructive surgery: Steps towards an
   international consensus
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Negative pressure wound therapy (NPWT); Consensus; Recommendations;
   Systematic review; Traumatic wounds; Reconstructive closure
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; THICKNESS SKIN-GRAFTS;
   SEVERE OPEN FRACTURES; FOREARM DONOR SITE; SUBATMOSPHERIC PRESSURE;
   CLINICAL-EXPERIENCE; LOWER-LIMBS; PEDIATRIC-PATIENTS; CONTROLLED-TRIAL
AB Negative pressure wound therapy (NPWT) has become widely adopted over the last 15 years and over 1000 peer reviewed publications are available describing its use. Despite this, there remains uncertainty regarding several aspects of usage. In order to respond to this gap a global expert panel was convened to develop evidence-based recommendations describing the use of NPWT. In this paper the results of the study of evidence in traumatic wounds (including soft tissue defects, open fractures and burns) and reconstructive procedures (including flaps and grafts) are reported. Evidence-based recommendations were obtained by a systematic review of the literature, grading of evidence, drafting of the recommendations by a global expert panel, followed by a formal consultative consensus development program in which 422 independent healthcare professionals were able to agree or disagree with the recommendations. The criteria for agreement were set at 80% approval. Evidence and recommendations were graded according to the SIGN (Scottish Intercollegiate Guidelines Network) classification system. Twelve recommendations were developed in total; 4 for soft tissue trauma and open fracture injuries, 1 for burn injuries, 3 for flaps and 4 for skin grafts. The present evidence base is strongest for the use of NPWT on skin grafts and weakest as a primary treatment for burns. In the consultative process, 11/12 of the proposed recommendations reached the 80% agreement threshold. The development of evidence-based recommendations for NPWT with direct validation from a large group of practicing clinicians offers a broader basis for consensus than work by an expert panel alone. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Runkel, N.] Black Forest Hosp, Dept Gen Surg, Villingen, Germany.
   [Runkel, N.] Univ Freiburg, D-7800 Freiburg, Germany.
   [Krug, E.] Leiden Univ, Med Ctr, NL-2300 RA Leiden, Netherlands.
   [Berg, L.] Kuopio Univ Hosp, Kuopio, Finland.
   [Lee, C.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Lee, C.] St Marys Hosp, San Francisco, CA USA.
   [Hudson, D.] Groote Schuur Hosp, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
   [Birke-Sorensen, H.] Hamlet Hosp, Aarhus, Denmark.
   [Depoorter, M.] Acad Hosp St Jan, Dept Plast & Reconstruct Surg, Brugge, Belgium.
   [Dunn, R.] Univ Massachusetts, Div Plast Surg, Sch Med, Worcester, MA 01605 USA.
   [Dunn, R.] Mem Hlth Care, Worcester, MA USA.
   [Jeffery, S.] Queen Elizabeth Hosp, Royal Ctr Def Med, Birmingham B15 2TH, W Midlands, England.
   [Duteille, F.] Hop Hotel Dieu, Aesthet & Reconstruct Surg Burn Unit, Nantes, France.
   [Bruhin, A.] Dept Trauma & Visceral Surg, Luzern, Switzerland.
   [Caravaggi, C.] Inst Clin Citta Studi, Ctr Treatment Diabet Foot Pathol, Milan, Italy.
   [Chariker, M.] Aesthet Plast Surg Inst, Louisville, KY USA.
   [Ferreira, F.] Hosp Pedro Hispano, Matosinhos Porto, Portugal.
   [Francos Martinez, J. M.] Hosp Univ Bellvitge, Endocrine Surg Unit, Barcelona, Spain.
   [Grudzien, G.] John Paul 2 Hosp, Dept Cardiovasc Surg & Transplantol, Krakow, Poland.
   [Ichioka, S.] Saitama Med Univ, Dept Plast & Reconstruct Surg, Saitama, Japan.
   [Ingemansson, R.] Univ Lund Hosp, Heart & Lung Div, Dept Cardiothorac Surg, Lund, Sweden.
   [Malmsjo, M.] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Malmsjo, M.] Skane Univ Hosp, Lund, Sweden.
   [Rome, P.] Royal Prince Alfred Hosp, Sydney, NSW, Australia.
   [Rome, P.] Concord Hosp, Sydney, NSW, Australia.
   [Vig, S.] Mayday Univ Hosp, London, England.
   [Martin, R.; Smith, J.] Smith & Nephew, Kingston Upon Hull, N Humberside, England.
C3 University of Freiburg; Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC; University of Eastern
   Finland; University of Eastern Finland Hospital; Kuopio University
   Hospital; University of California System; University of California San
   Francisco; University of Cape Town; University of Massachusetts System;
   University of Massachusetts Worcester; Royal Centre for Defence
   Medicine; University of Birmingham; Nantes Universite; CHU de Nantes;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona; Saitama Medical
   University; Lund University; Skane University Hospital; Lund University;
   Lund University; Skane University Hospital; University of Sydney; NSW
   Health; Royal Prince Alfred Hospital; Concord Repatriation General
   Hospital; Croydon University Hospital; Smith & Nephew
RP Runkel, N (通讯作者)，Postfach 2103, D-78011 Villingen Schwenningen, Germany.
EM norbert.runkel@sbk-vs.de
RI Birke-Sørensen, Hanne/B-6733-2015; jeffery, steven/A-5207-2013
OI jeffery, steven/0000-0001-6587-5412; Ingemansson,
   Richard/0000-0001-7623-8953; Martin, Robin/0000-0002-9314-0437; Maljö,
   Malin/0000-0001-9849-9599
FU Smith Nephew
FX Smith & Nephew provided funding for travel and accommodation for all
   face-to-face expert panel meetings, provided support regarding the
   published literature in NPWT, arranged and provided funding for the
   'consultative phase' of the project (a symposium to 422 Healthcare
   professionals in Hamburg Feb 2010), provided support during the drafting
   of recommendations (authors Jenny Smith and Robin Martin) and provided
   medical writing services in preparation of this manuscript (author Jenny
   Smith). The recommendations reflect the independent and unbiased views
   of the panel and the consensus derived during the project and the
   content of the manuscript has not been unfairly influenced by Smith &
   Nephew.
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NR 90
TC 136
Z9 165
U1 0
U2 29
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2011
VL 42
SU 1
BP S1
EP S12
DI 10.1016/S0020-1383(11)00041-6
PG 12
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 720UU
UT WOS:000287308900001
PM 21316515
DA 2026-07-24
ER
PT J
AU Raad, W
   Lantis, JC
   Tyrie, L
   Gendics, C
   Todd, G
AF Raad, Wissam
   Lantis, John C., II
   Tyrie, Leslie
   Gendics, Cynthia
   Todd, George
TI Vacuum-assisted closure instill as a method of sterilizing massive
   venous stasis wounds prior to split thickness skin graft placement
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Split thickness skin graft; Wound
   sterilisation
ID FOOT; OUTCOMES; ULCERS; TRIAL
AB Patients with massive venous stasis ulcers that have very high bacterial burdens represent some of the most difficult wounds to manage. The vacuum-assisted closure (VAC) device is known to optimise wound bed preparation; however, these patients have too high a bacterial burden for simple VAC application to facilitate this function. We present the application of the VAC with instillation of dilute Dakins solution as a way of bacterial eradication in these patients. Five patients with venous stasis ulcers greater than 200 cm(2) that were colonised with greater than 105 bacteria were treated with the VAC instill for 10 days with 12.5% Dakins solution, instilled for 10 minutes every hour. Two patients had multi-drug-resistant pseudomonas, three with MRSA. All the five had negative quantitative cultures, prior to split thickness skin graft with 100% take and complete healing at 1 year. Adequate delivery of bactericidal agents to the infected tissue can be very difficult, especially while promoting tissue growth. By providing a single delivery system for a bactericidal agent for a short period of time followed by a growth stimulating therapy, the VAC instill provides a unique combination that appears to maximise wound bed preparation.
C1 [Raad, Wissam; Lantis, John C., II; Tyrie, Leslie; Gendics, Cynthia; Todd, George] Columbia Univ, St Lukes Roosevelt Hosp, Dept Surg, New York, NY 10025 USA.
C3 Columbia University; Mount Sinai Morningside; Mount Sinai West
RP Lantis, JC (通讯作者)，Columbia Univ, St Lukes Roosevelt Hosp Ctr, Suite 7A,1090 Amsterdam Ave, New York, NY 10025 USA.
EM jcl161@columbia.edu
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NR 24
TC 45
Z9 54
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2010
VL 7
IS 2
BP 81
EP 85
DI 10.1111/j.1742-481X.2010.00658.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NN
UT WOS:000287513600003
PM 20529147
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Torbrand, C
   Ugander, M
   Engblom, H
   Olivecrona, GK
   Gålne, O
   Arheden, H
   Ingemansson, R
   Malmsjö, M
AF Torbrand, Christian
   Ugander, Martin
   Engblom, Henrik
   Olivecrona, Goran K.
   Galne, Olog
   Arheden, Hakan
   Ingemansson, Richard
   Malmsjo, Malin
TI Changes in cardiac pumping efficiency and intra-thoracic organ volume
   during negative pressure wound therapy of sternotomy wounds, assessment
   using magnetic resonance imaging
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Experimental surgery; Negative pressure wound therapy; Post-sternotomy
   mediastinitis; Sternotomy wound; Wound healing
ID VACUUM-ASSISTED CLOSURE; SURGERY; MEDIASTINITIS
AB Knowledge on the effects of negative pressure wound therapy (NPWT) on the intra-thoracic organs is limited. The present study was performed to investigate the effects of NPWT on the volume of the intra-thoracic organs, using magnetic resonance imaging (MRI), in a porcine sternotomy wound model. Six pigs underwent median sternotomy followed by NPWT at -75, -125 and -175 mmHg. Six pigs were not sternotomised. MR images covering the thorax and heart were acquired. The volumes of the thoracic cavity, lungs, wound fluid and heart were then determined. The volumes of the thoracic cavity and intra-thoracic organs increased after sternotomy and decreased upon NPWT application. The total heart volume variation, which is a measure of cardiac pumping efficiency, was higher after sternotomy and decreased during NPWT. NPWT did not result in the evacuation of wound fluid from the bottom of the wound. NPWT largely closes and restores the thoracic cavity. Cardiac pumping efficiency returns to pre-sternotomy levels during NPWT. This may contribute to the clinical benefits of NPWT over open-chest care, including the stabilizing effects and the reduced need for mechanical ventilation.
C1 [Malmsjo, Malin] Lund Univ, SE-22184 Lund, Sweden.
   [Torbrand, Christian; Galne, Olog; Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, SE-22184 Lund, Sweden.
   [Ugander, Martin; Engblom, Henrik; Arheden, Hakan] Univ Lund Hosp, Dept Clin Physiol, SE-22184 Lund, Sweden.
   [Olivecrona, Goran K.] Univ Lund Hosp, Dept Cardiol, SE-22184 Lund, Sweden.
   [Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, SE-22184 Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Skane University Hospital; Lund University; Skane University
   Hospital; Lund University; Skane University Hospital
RP Malmsjö, M (通讯作者)，Lund Univ, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Torbrand, Christian/HIZ-8092-2022; Ugander, Martin/AAQ-4447-2021
OI Torbrand, Christian/0000-0001-6442-7554; Maljö,
   Malin/0000-0001-9849-9599; Ingemansson, Richard/0000-0001-7623-8953;
   Ugander, Martin/0000-0003-3665-2038
CR Carlsson M, 2004, AM J PHYSIOL-HEART C, V287, pH243, DOI 10.1152/ajpheart.01125.2003
   Conquest AM, 2003, J SURG RES, V115, P209, DOI 10.1016/S0022-4804(03)00331-7
   Gotberg M, BMC CARDIOV IN PRESS
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   Kutschka I, 2004, ZBL CHIR, V129, pS33, DOI 10.1055/s-2004-822607
   Malmsjo M, J THORAC CA IN PRESS
   Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Petzina R, J THORAC CA IN PRESS
   Petzina R, 2007, J THORAC CARDIOV SUR, V133, P1154, DOI 10.1016/j.jtcvs.2007.01.011
   Ramnarine IR, 2002, EUR J CARDIO-THORAC, V22, P1029, DOI 10.1016/S1010-7940(02)00562-6
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   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
NR 13
TC 1
Z9 1
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2010
VL 7
IS 2
BP 115
EP 121
DI 10.1111/j.1742-481X.2010.00664.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NN
UT WOS:000287513600008
PM 20529152
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Nakayama, M
AF Nakayama, Mitsuyuki
TI Applying negative pressure therapy to deep pressure ulcers covered by
   soft necrotic tissue
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure therapy; Pressure ulcer
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; CELLS
AB Negative pressure therapy was applied to 39 deep pressure ulcers covered by soft necrotic tissue. All of the wounds were so deep that there were bones or ligaments just beneath the soft necrotic tissue. They had already received several types of conservative therapy including a necrotomy for periods ranging from 1 to 72 months. The wounds were minimally debrided and put in an adequately wet environment with negative pressure. This environment was established by the application of a suction-dressing. All of these wounds showed clear wound beds within only 1 month. All of the wounds were successfully cured, either with or without a musculocutaneous flap. Negative pressure wound therapy is thus considered to be one of the choices for the management of non healing deep pressure ulcers covered by soft necrotic tissue.
C1 Kanoiwa Hosp, Dept Vasc Surg, Yamanashi 4050018, Japan.
RP Nakayama, M (通讯作者)，Kanoiwa Hosp, Dept Vasc Surg, 1309 Kamikanogawa, Yamanashi 4050018, Japan.
EM mitsu88@mx5.nns.ne.jp
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Black Joyce, 2007, Dermatol Nurs, V19, P343
   Bucalo Brian, 1993, Wound Repair and Regeneration, V1, P181, DOI 10.1046/j.1524-475X.1993.10308.x
   Chen CS, 1997, SCIENCE, V276, P1425, DOI 10.1126/science.276.5317.1425
   Gwan-Nulla DN, 2001, ANN PLAS SURG, V47, P552, DOI 10.1097/00000637-200111000-00014
   Huang S, 1998, MOL BIOL CELL, V9, P3179, DOI 10.1091/mbc.9.11.3179
   Ingber D, 1991, CURR OPIN CELL BIOL, V3, P841, DOI 10.1016/0955-0674(91)90058-7
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   Tachi M, 2004, ANN PLAS SURG, V53, P338, DOI 10.1097/01.sap.0000129234.84192.d4
   URSCHEL JD, 1988, BRIT J PLAST SURG, V41, P182, DOI 10.1016/0007-1226(88)90049-5
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NR 12
TC 6
Z9 8
U1 0
U2 7
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2010
VL 7
IS 3
BP 160
EP 166
DI 10.1111/j.1742-481X.2010.00667.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NP
UT WOS:000287513800005
PM 20455957
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Assadian, O
   Assadian, A
   Stadler, M
   Diab-Elschahawi, M
   Kramer, A
AF Assadian, Ojan
   Assadian, Afshin
   Stadler, Maria
   Diab-Elschahawi, Magda
   Kramer, Axel
TI Bacterial growth kinetic without the influence of the immune system
   using vacuum-assisted closure dressing with and without negative
   pressure in an in vitro wound model
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Bacterial load; MRSA; Negative pressure wound therapy; Occlusive
   dressing; VAC therapy; Vacuum-assisted therapy
ID INFECTION; THERAPY
AB The physical capacity of negative pressure wound therapy (NPWT) dressing on the bacterial growth in an in vitro wound model was investigated. Standardised wounds were contaminated with a clinical Staphylococcus aureus strain and incubated at 35 degrees C for 6 hours. Four wounds were treated with continuous negative pressure (125 mmHg) and four controls without. Bacterial load per gram tissue and per gram polyurethane sponge were measured after 24, 36 and 72 hours. Without negative pressure, the initial mean S. aureus load per gram tissue was 1.42 x 10(4), with negative pressure 1.84 x 10(4), P = 0.294. After 24, 36 and 72 hours, both models yielded comparable numbers of organisms (24 hours: P = 0.081; 48 hours: P = 0.455; 72 hours: P = 0.825, respectively). Bacterial load of sponges with or without negative pressure also did not differ. Over a period of 72 hours, sponges with negative pressure yielded 1.60 x 108, those without negative pressure yielded 1.74 x 10(8) CFU/g sponge (P = 0.876). In non vital tissue without the influence of the immune system, the bacterial load did not decrease in our in vitro model using an NPWT dressing. This observation was independent of the physical effect of continuous negative pressure at 125 mmHg. The reduction in bacteria demonstrated in previous studies appears to be caused by other effects than physical suction alone. However, the results obtained are limited as non viable tissue was used and the effect of suction on dead tissue might be very different from that occurring on perfused tissue, for example, in an animal model or in patients.
C1 [Assadian, Ojan; Stadler, Maria; Diab-Elschahawi, Magda] Med Univ Vienna, Clin Inst Hyg & Med Microbiol, Div Hosp Hyg, A-1090 Vienna, Austria.
   [Assadian, Afshin] Wilhelminenspital Vienna, Dept Gen & Vasc Surg, Vienna, Austria.
   [Kramer, Axel] Ernst Moritz Arndt Univ Greifswald, Inst Hyg & Environm Med, Greifswald, Germany.
C3 Medical University of Vienna; Wilhelminenspital; Universitat Greifswald
RP Assadian, O (通讯作者)，Med Univ Vienna, Vienna Gen Hosp, Clin Inst Hyg & Med Microbiol, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM ojan.assadian@meduniwien.ac.at
RI ; Assadian, Ojan/H-9753-2019
OI Assadian, Ojan/0000-0003-0129-8761; Assadian, Ojan/0000-0003-0129-8761
FU Clinical Department for Hygiene and Medical Microbiology at the Medical
   University of Vienna
FX The financial support for this study was provided by the Clinical
   Department for Hygiene and Medical Microbiology at the Medical
   University of Vienna. The NPWT units and consumables used were kindly
   lent by the KCI Austria GmbH Company. The authors declare no conflict of
   interest. There has been no connection with any company or organisation,
   whose products are mentioned in this article, nor is there any link to a
   competitor for these products.
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NR 33
TC 47
Z9 56
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2010
VL 7
IS 4
BP 283
EP 289
DI 10.1111/j.1742-481X.2010.00686.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NS
UT WOS:000287514100008
PM 20550601
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Lee, KN
   Seo, DM
   Hong, JP
AF Lee, Kangwoo Nathan
   Seo, Dong Man
   Hong, Joon Pio
TI The effect and safety after extended use of continuous negative pressure
   of 75 mmHg over mesh and allodermis graft on open sternal wound from
   oversized heart transplant in a 3-month-old infant
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Heart transplant; Negative pressure therapy; Paediatric sternal wound
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; THERAPY; WALL
AB Negative pressure therapy (NPT) has been reported to be effective in treating infants with open chest wounds. This report further supports its effectiveness by treating a 3-month-old infant with a 12 x 7 cm sized opening in its chest after an oversized heart transplantation. After applying a mesh and allodermis over the defect, 75-mmHg continuous negative pressure was set and used for an extended period of 104 days. The haemodynamic status was evaluated during this period. The wound was closed with secondary intention and it healed well after NPT. There was no haemodynamic instability during the treatment course. The extended use of a continuous negative pressure of 75 mmHg over the mesh and alloderm graft was a reliable and safe option to close the massive defect in the chest of a 3-month-old infant.
C1 [Lee, Kangwoo Nathan; Seo, Dong Man; Hong, Joon Pio] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Plast Surg, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Hong, JP (通讯作者)，Univ Ulsan, Dept Thorac Surg, Asan Med Ctr, Coll Med, 86 Asan Beyoungwongil Poongnapdong Songpagu, Seoul, South Korea.
EM joonphong@amc.seoul.kr
RI ; Hong, Joon/AEV-0712-2022
OI Seo, Dong Man/0000-0002-5831-7954; 
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Kim EK, 2007, ANN PLAS SURG, V58, P536, DOI 10.1097/01.sap.0000245121.32831.47
   Kim H, 2006, AM J SURG, V192, P705, DOI 10.1016/j.amjsurg.2006.09.003
   Malmsjö M, 2009, J THORAC CARDIOV SUR, V138, P712, DOI 10.1016/j.jtcvs.2008.11.068
   Mokhtari A, 2006, ANN THORAC SURG, V82, P1063, DOI 10.1016/j.athoracsur.2006.04.085
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Petzina R, 2007, J THORAC CARDIOV SUR, V133, P1154, DOI 10.1016/j.jtcvs.2007.01.011
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
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   Vicchio M, 2007, J THORAC CARDIOV SUR, V134, P254, DOI 10.1016/j.jtcvs.2007.03.024
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
NR 15
TC 5
Z9 5
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2010
VL 7
IS 5
BP 379
EP 384
DI 10.1111/j.1742-481X.2010.00702.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NU
UT WOS:000287514300009
PM 20840183
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Lindstedt, S
   Ingemansson, R
AF Malmsjo, Malin
   Lindstedt, Sandra
   Ingemansson, Richard
TI Influence on pressure transduction when using different drainage
   techniques and wound fillers (foam and gauze) for negative pressure
   wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Animal model; Experimental surgery; Negative pressure wound therapy;
   Pressure transduction; Sternotomy wound; Wound fluid drainage; Wound
   healing
ID VACUUM-ASSISTED CLOSURE; FOUNDATION
AB Pressure transduction to the wound bed in negative pressure wound therapy (NPWT) is crucial in stimulating the biological effects ultimately resulting in wound healing. In clinical practice, either foam or gauze is used as wound filler. Furthermore, two different drainage techniques are frequently employed. One involves the connection of a non-perforated drainage tube to the top of the dressing, while the other involves the insertion of perforated drains into the dressing. The aim of this study was to examine the efficacy of these two different wound fillers and drainage systems on pressure transduction to the wound bed in a challenging wound (the sternotomy wound). Six pigs underwent median sternotomy. The wound was sealed for NPWT using different wound fillers (foam or gauze) and drainage techniques (see earlier). Pressures between 0 and -175 mmHg were applied and the pressure in the wound was measured using saline-filled catheters sutured to the bottom of the wound (over the anterior surface of the heart) and to the side of the wound (on the thoracic wall). The negative pressure on the wound bed increased linearly with the negative pressure delivered by the vacuum source. In a dry wound, the pressure transduction was similar when using the different wound fillers (foam and gauze) and drainage techniques. In a wet wound, pressure transduction was better when using a perforated drainage tube inserted into the wound filler than a non-perforated drainage tube connected to the top of the dressing (-116 +/- 1 versus -73 +/- 4 mmHg in the wound at a delivered pressure of -125 mmHg for foam, P < 0.01), regardless of the type of wound filler. Gauze and foam are equally effective at delivering negative pressure to the wound bed. Perforated drainage tubes inserted into the wound filler are more efficient than a non-perforated drainage tubes connected to the top of the dressing. The choice of drainage technique may be particularly important in wounds with a large volume of exudate.
C1 [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Malmsjo, Malin; Lindstedt, Sandra; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953; Lindstedt, Sandra/0000-0003-4484-6473
FU Ake-Wieberg Foundation; Magn Bergvall Foundation; Swedish Medical
   Association; Royal Physiographic Society in Lund; Crafoord Foundation;
   Swedish Heart-Lung Foundation; Swedish Hypertension Society; Smith &
   Nephew Wound Management
FX This study was funded by the Ake-Wieberg Foundation, the Magn Bergvall
   Foundation, the Swedish Medical Association, the Royal Physiographic
   Society in Lund, the Crafoord Foundation, the Swedish Heart-Lung
   Foundation, the Swedish Hypertension Society and Smith & Nephew Wound
   Management. We thank Robin Martin (Smith & Nephew) for review of the
   manuscript.
CR Banwell P E, 1999, J Wound Care, V8, P79
   Banwell P E, 2003, J Wound Care, V12, P22
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Evans D, 2001, BRIT J PLAST SURG, V54, P238, DOI 10.1054/bjps.2001.3547
   Gouttefangeas C, 2001, CLIN EXP IMMUNOL, V124, P398, DOI 10.1046/j.1365-2249.2001.01547.x
   Greene AK, 2006, ANN PLAS SURG, V56, P418, DOI 10.1097/01.sap.0000202831.43294.02
   Jones SM, 2005, PLAST RECONSTR SURG, V116, P1023, DOI 10.1097/01.prs.0000178399.68254.13
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   Torbrand C, 2008, INT WOUND J, V5, P579, DOI 10.1111/j.1742-481X.2007.00425.x
NR 13
TC 17
Z9 23
U1 0
U2 11
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2010
VL 7
IS 5
BP 406
EP 412
DI 10.1111/j.1742-481X.2010.00706.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NU
UT WOS:000287514300012
PM 20649833
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Hurd, T
   Chadwick, P
   Cote, J
   Cockwill, J
   Mole, TR
   Smith, JM
AF Hurd, Theresa
   Chadwick, Paul
   Cote, Julien
   Cockwill, John
   Mole, Trevor R.
   Smith, Jennifer M.
TI Impact of gauze-based NPWT on the patient and nursing experience in the
   treatment of challenging wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Gauze-based negative pressure wound therapy; Wound dimensions; Wound
   odour; Wound pain
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; RANDOMIZED-TRIAL; LEG
   ULCERS; THERAPY; MANAGEMENT; EFFICACY; GRAFTS; PAIN
AB Negative pressure wound therapy is widely used in the treatment of hard-to-heal wounds; however, pain during dressing changes, which is often associated with pain on the commencement and cessation of pressure application and because of in-growth of new granulation tissue into interstices of foam dressings, is often experienced. Anecdotal reports have suggested that choice of gauze as the negative pressure wound therapy dressing may reduce the pain associated with dressing changes. A prospective, multi-center, non-comparative clinical investigation was carried out using gauze-based negative pressure wound therapy in chronic and acute wounds. Over 152 patients were evaluated. Median duration of therapy was 18 days with 91% of patients progressing towards healing at the end of therapy. Wound pain and odour were significantly reduced (P < 0.001) over the course of therapy. Wound pain during dressing changes was reported to be absent in 80% of dressing removals. No damage to the wound bed following dressing removal was observed in 96% of dressing changes. Dressing applications were considered easy in 79% of assessments and took a median of 20 min to complete. In patients susceptible to pain, gauze-based negative pressure therapy may be a viable option to maximise patient comfort.
C1 [Hurd, Theresa] Nursing Practice Solut, Toronto, ON, Canada.
   [Chadwick, Paul] Salford Primary Care Trust, Salford, Lancs, England.
   [Cote, Julien] CHUQ, Quebec City, PQ, Canada.
   [Cockwill, John] Wound Management Inc, Smith & Nephew, St Petersburg, FL USA.
   [Mole, Trevor R.; Smith, Jennifer M.] Smith & Nephew Wound Management, Kingston Upon Hull HU3 2BN, N Humberside, England.
C3 Laval University; Laval University Hospital; Smith & Nephew; Smith &
   Nephew
RP Smith, JM (通讯作者)，Smith & Nephew, Adv Wound Devices, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM Jennifer.smith@smith-nephew.com
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Jorgensen B, 2006, WOUND REPAIR REGEN, V14, P233, DOI 10.1111/j.1743-6109.2006.00116.x
   Joseph E, 2000, WOUNDS, V12, P60
   Körber A, 2008, DERMATOLOGY, V216, P250, DOI 10.1159/000112937
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   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Loree S, 2004, J Wound Care, V13, P249
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   McCord SS, 2007, WOUND REPAIR REGEN, V15, P296, DOI 10.1111/j.1524-475X.2007.00229.x
   Mendonca D A, 2007, J Wound Care, V16, P49
   MOFFAT C, 2008, HARD HEAL WOUNDS HOL
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Ozturk E, 2009, AM J SURG, V197, P660, DOI 10.1016/j.amjsurg.2008.04.018
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   VUOLO JC, 2009, BR J NURS, V18, pS22
   Vuolo Julie Caroline, 2009, Br J Nurs, V18, pS22
NR 27
TC 30
Z9 37
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2010
VL 7
IS 6
BP 448
EP 455
DI 10.1111/j.1742-481X.2010.00714.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NW
UT WOS:000287514500003
PM 20673256
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Blume, PA
   Key, JJ
   Thakor, P
   Thakor, S
   Sumpio, B
AF Blume, Peter A.
   Key, Jonathan J.
   Thakor, Pratapji
   Thakor, Sejal
   Sumpio, Bauer
TI Retrospective evaluation of clinical outcomes in subjects with
   split-thickness skin graft: comparing V.A.C.® therapy and conventional
   therapy in foot and ankle reconstructive surgeries
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Split-thickness skin graft;
   Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; PRESSURE WOUND
   THERAPY; DRESSINGS; DEVICE; MULTICENTER; BOLSTER; ULCERS
AB This retrospective study compared the clinical outcomes of negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by Vacuum-Assisted Therapy (R) (V.A.C.(R) Therapy, KCI Licensing Inc., San Antonio, TX) to non-NPWT/ROCF conventional therapy (CT) in split-thickness skin graft (STSG) survival in all patients to determine whether NPWT/ROCF affects the outcome of the graft survival, in terms of overall graft take, duration of graft take, repeated grafts and complications.
   The authors conducted a 10-year retrospective review of 142 patients admitted to a level I trauma centre and treated with an STSG in foot and ankle reconstructive surgeries. Demographic data, wound etiology, dressing type used, time to graft take, NPWT/ROCF duration, complications and outpatient treatments were analysed. There were significantly fewer repeated STSGs required in the NPWT/ROCF group compared to CT [n = 3 (3.5%) versus n = 9 (16%); P = 0.006]. In assessing safety, there were fewer complications in graft failure (seroma, hematoma and infection) in the NPWT/ROCF group as compared to the CT group at 8.9 months (range: 1-12 months). NPWT/ROCF is an excellent alternative for securing an STSG and is associated with improved graft survival as measured by a reduction in the number of repeated STSGs and graft failure complications.
C1 [Blume, Peter A.; Sumpio, Bauer] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06520 USA.
   [Key, Jonathan J.; Thakor, Pratapji; Thakor, Sejal] Ctr Excellence Limb Preservat, New Haven, CT USA.
C3 Yale University
RP Blume, PA (通讯作者)，Yale Univ, Sch Med, Dept Surg, 333 Cedar St,TMP 3,POB 208051, New Haven, CT 06520 USA.
EM peter.b@snet.net
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   BLUME PA, 2004, LOWER EXTREMITY SOFT, P157
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Carson Stanley N, 2004, Ostomy Wound Manage, V50, P52
   Donato M C, 2000, Clin Podiatr Med Surg, V17, P561
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   Flack S, 2008, J Wound Care, V17, P71
   Hanasono MM, 2007, ANN PLAS SURG, V58, P573, DOI 10.1097/01.sap.0000237638.93453.66
   Joseph E, 2000, WOUNDS, V12, P60
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 29
TC 64
Z9 73
U1 0
U2 10
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2010
VL 7
IS 6
BP 480
EP 487
DI 10.1111/j.1742-481X.2010.00728.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NW
UT WOS:000287514500007
PM 20825510
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Wong, SL
   Schneider, AM
   Argenta, LC
   Morykwas, MJ
AF Wong, S. Lindsey
   Schneider, Andrew M.
   Argenta, Louis C.
   Morykwas, Michael J.
TI Loxoscelism and negative pressure wound therapy (vacuum-assisted
   closure): an experimental study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Brown recluse spider bite; Loxoscelism; Negative pressure wound therapy;
   Vacuum-assisted closure
ID RECLUSE SPIDER ENVENOMATION; SUBATMOSPHERIC PRESSURE; RABBIT MODEL;
   WHITE-RABBIT; SWINE MODEL; BITE; FOUNDATION
AB Brown recluse spider (Loxosceles) bites cause lesions ranging from chronic necrotic ulcers to acute life-threatening sepsis. Based on our experience in treating acute and chronic wounds with negative pressure, we postulated that vacuum-assisted closure (VAC) would be valuable in this application. Chester pigs were procured and injected with purified brown recluse spider venom, 1 mu l of venom in two anterior sites and 0.1 mu l of venom in two posterior sites on their dorsum. For each concentration of venom, treatment consisted of either VAC or dry, non adherent dressings (control group). Each day, the wounds were inspected and measured. For wounds receiving 1.0 mu l of venom, the control wounds decreased in surface area to 50% of initial size after 7 days and none had healed, whereas VAC-treated wounds were less than 50% after 48 hours and completely healed and reepithelialised after 8 days. Wounds with 0.1 mu l of venom had 50% reduction after 5 days with no complete healing for control wounds, and the VAC wounds were 50% after 48 hours and all had closed and reepithelialised after 5 days. Our experimental study showed an accelerated healing time in the animals treated with the VAC as compared with controls.
C1 [Wong, S. Lindsey; Schneider, Andrew M.; Argenta, Louis C.; Morykwas, Michael J.] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM mmorykwa@wfubmc.edu
OI Morykwas, Michael/0009-0001-5547-5172
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 18
TC 6
Z9 9
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2010
VL 7
IS 6
BP 488
EP 492
DI 10.1111/j.1742-481X.2010.00722.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NW
UT WOS:000287514500008
PM 20666855
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Sermoneta, D
   Di Mugno, M
   Spada, PL
   Lodoli, C
   Carvelli, ME
   Magalini, SC
   Cavicchioni, C
   Bocci, MG
   Martorelli, F
   Brizi, MG
   Gui, D
AF Sermoneta, D.
   Di Mugno, M.
   Spada, P. L.
   Lodoli, C.
   Carvelli, M. E.
   Magalini, S. C.
   Cavicchioni, C.
   Bocci, M. G.
   Martorelli, F.
   Brizi, M. G.
   Gui, D.
TI Intra-abdominal vacuum-assisted closure (VAC) after necrosectomy for
   acute necrotising pancreatitis: preliminary experience
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal infection; Acute pancreatitis; Laparostomy; Negative pressure;
   VAC
ID TEMPORARY ABDOMINAL CLOSURE; SURGICAL-TREATMENT; 7-YEAR EXPERIENCE; PACK
   TECHNIQUE; WOUND CONTROL; NECROSIS
AB Infection of pancreatic necrosis, although present in less than 10% of acute pancreatitis, carries a high risk of mortality; debridment and drainage of necrosis is the treatment of choice, followed by 'open' or 'close' abdomen management. We recently introduced the use of intra-abdominal vacuum sealing after a classic necrosectomy and laparostomy. Two patients admitted to ICU for respiratory insufficiency and a diagnosis of severe acute pancreatitis developed pancreatic necrosis and were treated by necrosectomy, lesser sac marsupialisation and posterior lumbotomic opening. Both of the patients recovered from pancreatitis and a good healing of laparostomic wounds was obtained with the use of the VAC system. Most relevant advantages of this technique seem to be: the prevention of abdominal compartment syndrome, the simplified nursing of patients and the reduction of time to definitive abdominal closure.
C1 [Sermoneta, D.; Di Mugno, M.; Spada, P. L.; Lodoli, C.; Carvelli, M. E.; Magalini, S. C.; Cavicchioni, C.; Gui, D.] Univ Cattolica Sacro Cuore, Emergency Surg Unit, Dept Surg, Policlin Gemelli, I-00168 Rome, Italy.
   [Bocci, M. G.; Martorelli, F.] Univ Cattolica Sacro Cuore, Intens Care Unit, Dept Anesthesiol, Policlin Gemelli, I-00168 Rome, Italy.
   [Brizi, M. G.] Univ Cattolica Sacro Cuore, Dept Radiol, Policlin Gemelli, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Sermoneta, D (通讯作者)，Univ Cattolica Sacro Cuore, Emergency Surg Unit, Dept Surg, Policlin Gemelli, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
EM daniel.s@tiscali.it
RI Martorelli, Federica/HKE-6474-2023; Bocci, Maria Grazia/AAL-1170-2020
OI Martorelli, Federica/0000-0002-9690-2548; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   BRADLEY EL, 1993, ARCH SURG-CHICAGO, V128, P586
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   Connor S, 2005, SURGERY, V137, P499, DOI 10.1016/j.surg.2005.01.003
   Götzinger P, 2002, WORLD J SURG, V26, P474, DOI 10.1007/s00268-001-0252-8
   Gui D, 2008, LANGENBECK ARCH SURG, V393, P373, DOI 10.1007/s00423-007-0202-5
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NR 21
TC 11
Z9 17
U1 0
U2 5
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2010
VL 7
IS 6
BP 525
EP 530
DI 10.1111/j.1742-481X.2010.00727.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NW
UT WOS:000287514500014
PM 20726923
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Whitehead, SJ
   Forest-Bendien, VL
   Richard, JL
   Halimi, S
   Van, GH
   Trueman, P
AF Whitehead, Sarah J.
   Forest-Bendien, Veronique L.
   Richard, Jean-Louis
   Halimi, Serge
   Van, Georges Ha
   Trueman, Paul
TI Economic evaluation of Vacuum Assisted Closure® Therapy for the
   treatment of diabetic foot ulcers in France
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cost-effectiveness; Diabetic foot ulcers; Negative pressure therapy; VAC
   (R) Therapy
ID PRESSURE WOUND THERAPY; COST-EFFECTIVENESS; AMPUTATIONS; MULTICENTER;
   PREVALENCE; CARE
AB The objective of the study was to assess the cost-effectiveness of Vacuum Assisted Closure (R) (V.A.C.(R)) Therapy compared with advanced wound care (AWC) for the treatment of diabetic foot ulcers (DFUs) in France. A cost-effectiveness model intended to reflect the management of DFUs was updated for the French setting. The Markov model follows the progression of 1000 hypothetical patients over a 1-year period. The model was populated with French-specific data, obtained from published sources and clinical experts. The analysis evaluated costs and health outcomes, in terms of quality-adjusted life-years (QALYs), wounds healed and amputations, from the perspective of the payer. The patients treated with V.A.C.(R) Therapy experienced more QALYs (0.787 versus 0.784) and improved healing rates (50.2% versus 48.5%) at a lower total cost of care ((sic)24 881 versus (sic)28 855 per patient per year) when compared with AWC. Sensitivity analyses conducted around key model parameters indicated that the results were affected by hospital resource use and costs. DFU treatment using V.A.C.(R) Therapy in France was associated with lower costs, additional QALYs, more healed ulcers and fewer amputations than treatment with AWC. V.A.C.(R) Therapy was therefore found to be the dominant treatment option.
C1 [Whitehead, Sarah J.] Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England.
   [Forest-Bendien, Veronique L.] KCI Europe Holding, Amstelveen, Netherlands.
   [Richard, Jean-Louis] Univ Nimes Hosp, Ctr Med, Serv Malad Nutr & Diabetol, Dept Nutr Dis & Diabetol, Nimes, France.
   [Halimi, Serge] CHU Grenoble, Univ Hosp Grenoble, Serv Endocrinol Diabetol Nutr, F-38043 Grenoble, France.
   [Van, Georges Ha] Clin Trois Soleils, Boissise Le Roi, France.
   [Trueman, Paul] Brunel Univ, Hlth Econ Res Grp, London, England.
C3 University of York - UK; Universite de Montpellier; CHU de Nimes; CHU
   Grenoble Alpes; Communaute Universite Grenoble Alpes; Universite
   Grenoble Alpes (UGA); Brunel University
RP Whitehead, SJ (通讯作者)，Univ York, Dept Hlth Sci, York Trials Unit, ARRC Bldg, York YO10 5DD, N Yorkshire, England.
EM sjw138@york.ac.uk
OI HA VAN, GEORGES/0000-0002-8024-8385
FU KCI Europe Holding (Amstelveen, the Netherlands)
FX Funding for this study was provided by KCI Europe Holding (Amstelveen,
   the Netherlands). VL Forest-Bendien, an employee of KCI Europe Holding,
   was involved in the data collection. This work is attributed to York
   Health Economics Consortium, University of York, UK. The V.A.C.(R)
   Therapy System and certain components and methods are subject to one or
   more of the following patents: USA: 5636643, 5645081, 6142982, 6345623,
   6553998, 6814079, 7004915, 7198046, 7216651; EU: EP777504, EP620720,
   EP865304, EP1088569, EP853950, EP1018967, EP1219311, EP1440667; other
   patents pending.
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NR 42
TC 15
Z9 19
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2011
VL 8
IS 1
BP 22
EP 32
DI 10.1111/j.1742-481X.2010.00739.x
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723OD
UT WOS:000287515200003
PM 20875048
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Atkins, BZ
   Tetterton, JK
   Petersen, RP
   Hurley, K
   Wolfe, WG
AF Atkins, Broadus Zane
   Tetterton, Jean K.
   Petersen, Rebecca P.
   Hurley, Kista
   Wolfe, Walter G.
TI Laser Doppler flowmetry assessment of peristernal perfusion after
   cardiac surgery: beneficial effect of negative pressure therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure; Sub-atmospheric pressure; Surgery; Thoracic; Wound
   healing
ID VACUUM-ASSISTED CLOSURE; SURGICAL-SITE INFECTIONS; BYPASS GRAFT-SURGERY;
   BLOOD-FLOW; RISK-FACTORS; WOUND THERAPY; THORACIC WALL; ARTERY;
   MORTALITY; SURVIVAL
AB Negative pressure therapy has been successfully applied to clean, closed incisions in patients at high-risk for wound complications. Using laser Doppler flowmetry, we evaluated peristernal perfusion after cardiac surgery via median sternotomy, assessing the influence of mammary artery harvesting and the impact of negative pressure therapy. Twenty adult patients underwent median sternotomy for cardiac surgery followed by routine closure. Negative pressure was applied at 125 mm Hg for 4 days postoperatively in patients with increased risk for wound complications (n = 10, negative pressure group); standard dressings were applied to control incisions postoperatively (n = 10). Presternal perfusion was determined at baseline and daily for 4 days postoperatively using laser Doppler flowmetry. Results within and between groups were compared with analysis of variance. No wound complications were encountered in either group. Perfusion increased among the patients who underwent negative pressure therapy and decreased among the controls (P = 0.004). Mammary artery harvesting reduced peristernal perfusion by 25.7% in the controls, but negative pressure increased perfusion by 100% after mammary harvesting (P = 0.04). Negative pressure therapy increased perfusion relative to controls and compensated for reduced perfusion rendered by mammary artery harvesting, providing additional support for 'well wound therapy' in high-risk patients.
C1 [Atkins, Broadus Zane] Durham VA Med Ctr, Dept Surg, Surg Serv, Durham, NC 27705 USA.
   [Atkins, Broadus Zane] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
   [Tetterton, Jean K.; Wolfe, Walter G.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
   [Petersen, Rebecca P.] Univ Washington, Dept Surg, Sch Med Seattle, Seattle, WA 98195 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Durham VA Medical Center; Uniformed Services University of the Health
   Sciences - USA; Duke University; University of Washington; University of
   Washington Seattle
RP Atkins, BZ (通讯作者)，Durham VA Med Ctr, Dept Surg, Surg Serv, 112,508 Fulton St, Durham, NC 27705 USA.
EM Broadus.atkins@va.gov
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NR 31
TC 49
Z9 54
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2011
VL 8
IS 1
BP 56
EP 62
DI 10.1111/j.1742-481X.2010.00743.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723OD
UT WOS:000287515200006
PM 21167000
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Rajakaruna, C
   Marchbank, A
AF Rajakaruna, Chanaka
   Marchbank, Adrian
TI Gauze-based negative pressure wound therapy to infected deep sternotomy
   wound complicated by cardiac tamponade: a case report
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE cardiac surgery; negative pressure wound therapy; wound infection;
   tamponade
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; MULTICENTER;
   SURGERY; RUPTURE
AB Negative pressure wound therapy is the standard of care for infections after median sternotomy. Foam-based systems are commonly used even in scenarios when the myocardium is exposed. Gauze-based systems have recently gained popularity. We describe a case of deep sternal dehiscence that lead to a life-threatening complication secondary to wound filler choice.
C1 [Rajakaruna, Chanaka; Marchbank, Adrian] Derriford Hosp, SW Cardiothorac Ctr, Plymouth PL6 8DH, Devon, England.
C3 Derriford Hospital
RP Rajakaruna, C (通讯作者)，Bristol Royal Infirm & Gen Hosp, Bristol Heart Inst, Dept Cardiothorac Surg, Level 7, Bristol BS2 8HW, Avon, England.
EM cha.rajakaruna@gmail.com
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Bapat V, 2008, J CARDIAC SURG, V23, P227, DOI 10.1111/j.1540-8191.2008.00595.x
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
   Hunter Judith E, 2007, Int Wound J, V4, P256, DOI 10.1111/j.1742-481X.2007.00361.x
   Malmsjö M, 2009, ANN PLAS SURG, V63, P676, DOI 10.1097/SAP.0b013e31819ae01b
   Mokhtari A, 2008, SCAND CARDIOVASC J, V42, P85, DOI 10.1080/14017430701744469
   Mokhtari A, 2006, ANN THORAC SURG, V82, P1063, DOI 10.1016/j.athoracsur.2006.04.085
   Sachithanandan A, 2008, EUR J CARDIO-THORAC, V33, P673, DOI 10.1016/j.ejcts.2008.01.002
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
NR 12
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2011
VL 8
IS 1
BP 96
EP 98
DI 10.1111/j.1742-481X.2010.00738.x
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723OD
UT WOS:000287515200011
PM 20880376
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Kiessling, AH
   Lehmann, A
   Isgro, F
   Moritz, A
AF Kiessling, Arndt H.
   Lehmann, Andreas
   Isgro, Frank
   Moritz, Anton
TI Tremendous bleeding complication after vacuum-assisted sternal closure
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID CARDIAC-SURGERY; WOUND INFECTIONS; MANAGEMENT; THERAPY
AB Vacuum-assisted closure (VAC) of complex infected wounds has recently gained popularity among various surgical specialties. The system is based on the application of negative pressure by controlled suction to the wound surface. The effectiveness of the VAC System on microcirculation and the promotion of granulation tissue proliferation are proved. No contraindications for the use in deep sternal wounds in cardiac surgery are described. In our case report we illustrate a scenario were a patient developed severe bleeding from the ascending aorta by penetration of wire fragments in the vessel. We conclude that all free particles in the sternum have to be removed completely before negative pressure is used.
C1 [Kiessling, Arndt H.; Moritz, Anton] Goethe Univ Frankfurt, Dept Thorac & Cardiovasc Surg, Frankfurt, Germany.
   [Isgro, Frank] Klinikum Ludwigshafen, Dept Cardiac Surg, D-67069 Ludwigshafen, Germany.
C3 Goethe University Frankfurt; Ludwigshafen Hospital
RP Kiessling, AH (通讯作者)，Goethe Univ Frankfurt, Dept Thorac & Cardiovasc Surg, Frankfurt, Germany.
EM cardiac.surgeon@dr-kiessling.com
RI Kiessling, Arndt-H/AAI-7261-2020
OI Kiessling, Arndt-H/0000-0003-0472-755X
CR Doss M, 2002, EUR J CARDIO-THORAC, V22, P934, DOI 10.1016/S1010-7940(02)00594-8
   Graf K, 2010, EUR J CARDIO-THORAC, V37, P893, DOI 10.1016/j.ejcts.2009.10.005
   Grauhan O, 2010, INTERACT CARDIOV TH, V11, P493, DOI 10.1510/icvts.2010.238105
   Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   Reiss N, 2007, ANN THORAC SURG, V83, P2246, DOI 10.1016/j.athoracsur.2006.07.077
   Schimmer C, 2008, THORAC CARDIOV SURG, V56, P200, DOI 10.1055/s-2008-1038386
   Schimmer Christoph, 2007, Interact Cardiovasc Thorac Surg, V6, P708, DOI 10.1510/icvts.2007.164004
   Strecker T, 2007, HEART SURG FORUM, V10, pE366, DOI 10.1532/HSF98.20071079
   Wetzel-Roth W, 2004, ZBL CHIR, V129, pS7, DOI 10.1055/s-2004-822677
   White RA, 2005, J ORTHOP TRAUMA, V19, P56, DOI 10.1097/00005131-200501000-00011
NR 10
TC 17
Z9 21
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD FEB 9
PY 2011
VL 6
AR 16
DI 10.1186/1749-8090-6-16
PG 3
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 725PM
UT WOS:000287657800001
PM 21306630
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jäger, C
   Zeichen, J
AF Jaeger, C.
   Zeichen, J.
TI Acute lower leg compartment syndrome
SO OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE
LA German
DT Article
DE Compartment syndrome; Lower extremity; Decompression; Dermatofasciotomy
ID VACUUM-ASSISTED CLOSURE; INTRAMUSCULAR PRESSURE; TIBIAL FRACTURES;
   FASCIOTOMY; DERMATOFASCIOTOMY; THERAPY
AB Decompression of all four muscle compartments of the lower leg to normalize tissue pressure and prevent permanent neuromuscular dysfunction.
   Incipient compartment syndrome (characterized by excessive pain, muscle pain on extension, tensely swollen and shiny skin, and Delta p > 30 mmHg without neuromuscular deficit) and no clinical improvement after conservative treatment and/or acute compartment syndrome (symptoms as for incipient compartment syndrome with neuromuscular deficit and Delta p < 30 mmHg).
   None. There is some dispute about indications and timing of fasciotomy and necrectomy when the need for dermatofasciotomy is recognized late (e.g. intubated intensive care patients).
   In unilateral compartment release as described by Matsen, the lateral compartment is decompressed first through a parafibular approach. After identification of the anterior and superficial posterior compartments by transverse incision of the fasciae, these muscles are also decompressed longitudinally. Finally, the deep posterior compartment beneath the lateral compartment is decompressed. In bilateral dermatofasciotomy, the fasciae of the anterior and lateral compartments are incised through a proximal anterolateral approach and the superficial and deep posterior compartments through a distal dorsomedial approach.
   Synthetic skin substitute or vacuum-assisted wound closure until definitive closure by secondary suture or mesh grafting after about 5 days. Patient mobilization generally depends on the concomitant bone injury.
   During the period from October 2001 to November 2008, 37 dermatofasciotomies were performed at our hospital to treat acute posttraumatic compartment syndrome. On the day of dismissal, symptoms of neuromuscular dysfunction after acute compartment syndrome had not disappeared completely in 5 patients. One patient received intermittent dialysis for acute kidney failure after crush syndrome. There were perioperative complications in a total of 6 patients: iatrogenic neurotomy (n=1), hematoma requiring revision (n=2), deep wound infection (n=2), and superficial disturbed wound healing (n=1).
C1 [Jaeger, C.; Zeichen, J.] Johannes Wesling Klinikum Minden, Klin Unfallchirurg & Orthopadie, D-32429 Minden, Germany.
C3 Ruhr University Bochum
RP Jäger, C (通讯作者)，Johannes Wesling Klinikum Minden, Klin Unfallchirurg & Orthopadie, Hans Nolte Str 1, D-32429 Minden, Germany.
EM christian.jaeger@klinikum-minden.de
CR ADKISON DP, 1991, J BONE JOINT SURG AM, V73A, P112, DOI 10.2106/00004623-199173010-00014
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   SANGMEISTER M, 1998, KOMPARTMENTSYNDROM, V267, P178
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   TSCHERNE H, 1982, UNFALLHEILKUNDE, V85, P111
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   Yang Charlie C, 2006, J Surg Orthop Adv, V15, P19
NR 24
TC 4
Z9 5
U1 0
U2 19
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0934-6694
EI 1439-0981
J9 OPER ORTHOP TRAUMATO
JI Oper. Orthopade Traumatol.
PD FEB
PY 2011
VL 23
IS 1
BP 5
EP 14
DI 10.1007/s00064-010-0010-x
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 726WS
UT WOS:000287758100002
PM 21340447
DA 2026-07-24
ER
PT J
AU Köhler, D
   Pohlemann, T
AF Koehler, D.
   Pohlemann, T.
TI Operative treatment of the peripelvic Morel-Lavall,e lesion
SO OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE
LA German
DT Article
DE Morel-Lavallee lesion; Pelvic ring injuries; Operative therapy; Vacuum
   therapy; Wound healing
ID VACUUM-ASSISTED CLOSURE; DEGLOVING INJURIES; WOUND CONTROL
AB Evacuation of hematoma, hemostasis, reduction of dead space by vacuum systems for minimization of secondary complications, such as full skin necrosis, deep infections, and secondary wound closure.
   Morel-Lavall,e lesion (MLL), all larger epifascial hematomas.
   None.
   Central longitudinal incision, detection of the extent of the hematoma, transection of the full length of the lesion, hemostasis, debridement, application of vacuum systems, secondary wound closure, or splitskin coverage.
   Vacuum therapy must be continued until secretions are less than 30 ml/24 hours. Negative bacterial culture before wound closure is imperative. Daily change of wound dressings, frequent control of inflammation parameters. Weight bearing until consolidation of soft tissue.
   Operative treatment of the MLL with vacuum systems is a relatively new concept, and results on larger collectives have not been published yet. A total of 8 patients in our hospital underwent vacuum therapy after sustaining a MLL, 5 of them with concomitant instability of the pelvic ring. Emergency stabilization and initiation of vacuum therapy were performed on the day of admission. Three patients had initially positive bacterial colonialization. Duration of vacuum therapy was 8.5 days (range 4-14 days). Dressings were changed every 2.6 days (range 1-4 days). While 6 wounds could be closed secondarily, 2 needed split skin coverage. Complications were not observed. Vacuum therapy facilitates wound management and helps reduce bacterial colonialization. It has also been proved to have a beneficial effect on qualitative and quantitative granulation.
C1 [Koehler, D.; Pohlemann, T.] Univ Klinikum Saarlandes, Klin Unfall Hand & Wiederherstellungschirurg, D-66421 Homburg, Germany.
C3 Universitatsklinikum des Saarlandes
RP Köhler, D (通讯作者)，Univ Klinikum Saarlandes, Klin Unfall Hand & Wiederherstellungschirurg, Kirrbergerstr 1, D-66421 Homburg, Germany.
EM daniel.koehler@uks.eu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
   Giannoudis PV, 2004, INJURY, V35, P671, DOI 10.1016/j.injury.2004.03.003
   Hak DJ, 1997, J TRAUMA, V42, P1046, DOI 10.1097/00005373-199706000-00010
   HUDSON DA, 1992, PLAST RECONSTR SURG, V89, P853, DOI 10.1097/00006534-199205000-00013
   KELLAM JF, 1987, ORTHOP CLIN N AM, V18, P25
   Labler L, 2007, LANGENBECK ARCH SURG, V392, P601, DOI 10.1007/s00423-006-0090-0
   Letournel E, 1993, FRACT ACETABULUM SPR, P363
   Morel-Lavallee VAF, 1863, ARCH GEN MED, V1, P20
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   STEINER CL, 2008, EUR J TRAUMA, V34, P708
NR 12
TC 7
Z9 9
U1 0
U2 6
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0934-6694
J9 OPER ORTHOP TRAUMATO
JI Oper. Orthopade Traumatol.
PD FEB
PY 2011
VL 23
IS 1
BP 15
EP 20
DI 10.1007/s00064-010-0003-9
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 726WS
UT WOS:000287758100003
PM 21327954
DA 2026-07-24
ER
PT J
AU Wright, A
   Wright, M
AF Wright, Aaron
   Wright, Monica
TI Bedside Management of an Abdominal Wound Containing an Enteroatmospheric
   Fistula: A Case Report
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE surgery; complication; enteroatmospheric fistula; nursing care; negative
   pressure
ID VACUUM-ASSISTED CLOSURE; ENTEROCUTANEOUS FISTULAS
AB Enteroatmospheric fistulae (EAF) - unnatural connections between the bowel and the outside environment - are a feared complication of major abdominal operations. EAF pose a life-threatening risk to patients already weakened by surgical insult by altering fluid and electrolyte balance and fostering malnutrition. The authors describe a method of wound management for a 64-year-old morbidly obese woman with a history of coronary artery disease, diabetes mellitus, and bipolar disorder who developed a large abdominal wound containing multiple high-output EAF after an incarcerated abdominal hernia repair, wound infection, and subsequent laparotomy and lysis of adhesions followed by graft placement and negative pressure wound therapy. The volume, consistency, and location of the EAF caused commercial negative pressure devices to fail and simple gauze dressings were ineffective in maintaining a clean wound base and containing odor. Effluent collection and wound healing was achieved utilizing a modified method of EAF management that included two connecting rubberized catheter drains and continuous wound irrigation with wall suction and cotton gauze for debridement. Surgical EAF closure was successful after 6 months of care. This method provided a satisfactory balance between the diagnosis of EAF and the readiness to meet the physiologic demands of definitive surgical treatment.
C1 [Wright, Aaron] UC Davis Med Ctr, Trauma Program, Sacramento, CA USA.
   [Wright, Monica] UC Davis Med Ctr, Trauma Nursing Unit, Sacramento, CA USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis
RP Wright, A (通讯作者)，UC Davis Trauma Program, 2315 Stockton Blvd,Room 4212, Sacramento, CA 95817 USA.
EM aaron.wright@ucdmc.ucdavis.edu
CR Al-Khoury G, 2008, J AM COLL SURGEONS, V206, P397, DOI 10.1016/j.jamcollsurg.2007.07.027
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   Foster CE, 1996, SURG CLIN N AM, V76, P1019, DOI 10.1016/S0039-6109(05)70496-5
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   Hahler B, 2009, OSTOMY WOUND MANAG, V55, P30
   Hwang, 2000, Curr Surg, V57, P443, DOI 10.1016/S0149-7944(00)00319-6
   Kaushal Manish, 2004, Clin Colon Rectal Surg, V17, P79, DOI 10.1055/s-2004-828654
   Layton B, 2010, Am J Surg, V199, P48
   Lynch AC, 2004, ANN SURG, V240, P825, DOI 10.1097/01.sla.0000143895.17811.e3
   Miller MS, 2005, OSTOMY WOUND MANAG, V51, P44
   Ovington L.G., 2002, Adv Skin Wound Care, V15, P79
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   Ramsay PT, 2010, AM SURGEON, V76, P637
   Rao M, 2007, COLORECTAL DIS, V9, P266, DOI 10.1111/j.1463-1318.2006.01154.x
   Schecter WP, 2009, J AM COLL SURGEONS, V209, P484, DOI 10.1016/j.jamcollsurg.2009.05.025
   Stawicki S. P., 2008, OPUS 12SCIENTIST, V2, P13
   WEINSTEIN D, 2008, WORLD J SURG, V32, P430
   Wessel Linda Cunningham, 2002, Ostomy Wound Manage, V48, P26
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NR 30
TC 1
Z9 3
U1 0
U2 9
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JAN
PY 2011
VL 57
IS 1
BP 28
EP 32
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 727XU
UT WOS:000287837400008
PM 21252397
DA 2026-07-24
ER
PT J
AU D'Hondt, M
   D'Haeninck, A
   Dedrye, L
   Penninckx, F
   Aerts, R
AF D'Hondt, M.
   D'Haeninck, A.
   Dedrye, L.
   Penninckx, F.
   Aerts, R.
TI Can vacuum-assisted closure and instillation therapy
   (VAC-InstillA® therapy) play a role in the treatment of the
   infected open abdomen?
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE VAC-Instill; Infection; Open abdomen
ID WOUND CONTROL
AB Severe superimposed infection during open abdomen treatment with development of intra-abdominal sepsis is a challenging complication associated with high mortality rates. We report our experience with VAC-Instill(A (R)) therapy (KCI, San Antonio, USA) used for treatment of an infected open abdomen following pancreatic surgery. A literature search revealed no analogous case reports using VAC-Instill(A (R)) therapy for treatment of an infected laparostomy. The encouraging result of the case presented seems to indicate that VAC-Instill(A (R)) therapy could be used as adjunctive treatment in the management of the infected open abdomen when traditional therapy fails to control the infection.
C1 [D'Hondt, M.; D'Haeninck, A.; Dedrye, L.; Penninckx, F.; Aerts, R.] Univ Hosp Leuven, Dept Digest Surg, B-3000 Louvain, Belgium.
C3 KU Leuven; University Hospital Leuven
RP D'Hondt, M (通讯作者)，Kleine Leiestr 1, B-8500 Kortrijk, Belgium.
EM mathieudhondt2000@yahoo.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bryskier A, 2005, ANTIMICROBIAL AGENTS: ANTIBACTERIALS AND ANTIFUNGALS, pXXVII
   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
   Jernigan TW, 2003, ANN SURG, V238, P349, DOI 10.1097/01.sla.0000086544.42647.84
   Martin RR, 1997, SURG CLIN N AM, V77, P929, DOI 10.1016/S0039-6109(05)70595-8
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Wolvos Tom, 2004, Ostomy Wound Manage, V50, P56
NR 7
TC 24
Z9 30
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1123-6337
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD MAR
PY 2011
VL 15
IS 1
BP 75
EP 77
DI 10.1007/s10151-010-0662-4
PG 3
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 728CF
UT WOS:000287850900011
PM 21234637
DA 2026-07-24
ER
PT J
AU Armstrong, DG
   Marston, WA
   Reyzelman, AM
   Kirsner, RS
AF Armstrong, David G.
   Marston, William A.
   Reyzelman, Alexander M.
   Kirsner, Robert S.
TI Comparison of negative pressure wound therapy with an ultraportable
   mechanically powered device vs. traditional electrically powered device
   for the treatment of chronic lower extremity ulcers: A multicenter
   randomized-controlled trial
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; SYSTEM; STATE; CARE
AB The purpose of this study was to compare the ultraportable mechanically powered Smart Negative Pressure (SNaP(R)) Wound Care System to the traditional electrically powered Vacuum-Assisted Closure (VAC(R)) Therapy System in the treatment of chronic lower extremity wounds. This 12-center randomized-controlled trial of patients with noninfected, nonischemic, nonplantar lower extremity wounds had enrolled 65 patients, as of January 5, 2010, at the time of a planned interim analysis. Subjects were randomly assigned to treatment with either the SNaP(R) or VAC(R) Systems. The trial evaluated treatment for up to 16 weeks or till complete closure was achieved. Fifty-three patients (N527 SNaP(R), N526 VAC(R)) completed at least 4 weeks of therapy. Thirty-three patients (N518 SNaP(R), N515 VAC(R)) completed the study with either healing or 16 weeks of therapy. At the time of planned interim analysis, no significant differences (p=0.99) in the proportion of subjects healed between the two devices evaluated were found. In addition, the percent wound size reduction between treatment groups was not significantly different at 4, 8, 12, and 16 weeks, with noninferiority analysis at 4 weeks of treatment reaching the p-value <0.05 significance level (*p=0.019). These interim data suggest no difference in wound closure between the SNaP(R) System and the VAC(R) System in the population studied. We look forward to the final analysis results.
C1 [Armstrong, David G.] Univ Arizona, Coll Med, SALSA, Tucson, AZ 85721 USA.
   [Marston, William A.] Univ N Carolina, Div Vasc Surg, Dept Surg, Sch Med, Chapel Hill, NC USA.
   [Reyzelman, Alexander M.] Samuel Merritt Univ, Dept Med, Calif Sch Podiatr Med, Oakland, CA USA.
   [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
C3 University of Arizona; University of North Carolina; University of North
   Carolina Chapel Hill; University of North Carolina School of Medicine;
   Samuel Merritt University; University of Miami
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, SALSA, Tucson, AZ 85721 USA.
EM armstrong@usa.net
FU Spiracur Inc.; Spiracur; K.C.I.
FX This study was sponsored by a grant from Spiracur Inc., manufacturer of
   the SnAP(R) device. Two authors (Drs. Armstrong and Marston) have
   received research funding from both Spiracur and K.C.I.
CR Apostoli Alberto, 2008, Prof Inferm, V61, P158
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NR 19
TC 24
Z9 26
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2011
VL 19
IS 2
BP 173
EP 180
DI 10.1111/j.1524-475X.2010.00658.x
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 728ML
UT WOS:000287878100226
PM 21362084
DA 2026-07-24
ER
PT J
AU Baharestani, MM
   Gabriel, A
AF Baharestani, Mona Mylene
   Gabriel, Allen
TI Use of negative pressure wound therapy in the management of infected
   abdominal wounds containing mesh: an analysis of outcomes
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Infected abdominal wound; Negative pressure wound therapy; NPWT;
   Synthetic mesh; Vacuum assisted closure
ID VACUUM-ASSISTED CLOSURE; INCISIONAL HERNIA REPAIR; CLINICAL-EXPERIENCE;
   VENTRAL HERNIA; WALL DEFECTS; COMPLICATIONS; TRIAL
AB The purpose of this study was to examine the clinical outcomes of negative pressure wound therapy (NPWT) using reticulated open-cell foam (ROCF) in the adjunctive management of abdominal wounds with exposed and known infected synthetic mesh. A non randomised, retrospective review of medical records for 21 consecutive patients with infected abdominal wounds treated with NPWT was conducted. All abdominal wounds contained exposed synthetic mesh [composite, polypropylene (PP), or knitted polyglactin 910 (PG) mesh]. Demographic and bacteriological data, wound history, pre-NPWT and comparative post-NPWT, operative procedures and complications, hospital length of stay (LOS) and wound healing outcomes were all analysed. Primary endpoints measured were (1) hospital LOS prior to initiation of NPWT, (2) total time on NPWT, (3) hospital LOS from NPWT initiation to discharge and (4) wound closure status at discharge. A total of 21 patients with abdominal wounds with exposed, infected mesh were treated with NPWT. Aetiology of the wounds was ventral hernia repair (n = 11) and acute abdominal wall defect (n = 10). Prior to NPWT initiation, the mean hospital LOS for the composite, PP and PG meshes were 76 days (range: 21-171 days), 51 days (range: 32-62 days) and 19 days (range: 12-39 days), respectively. The mean hospital LOS following initiation of NPWT for wounds with exposed composite, PP and PG mesh were 28, 31 and 32 days, respectively. Eighteen of the 21 wounds (86%) reached full closure after a mean time of 26 days of NPWT and a mean hospital LOS of 30 days postinitiation of NPWT. Three wounds, all with composite mesh left in situ, did not reach full closure, although all exhibited decreased wound dimensions, granulating beds and decreased surface area exposure of mesh. During NPWT/ROCF, one hypoalbuminemic patient with exposed PP mesh developed an enterocutaneous fistula over a prior enterotomy site. This patient subsequently underwent total mesh extraction, takedown of the fistula and PP mesh replacement followed by reinstitution of NPWT and flap closure. In addition to appropriate systemic antibiotics and nutritional optimisation, the adjunctive use of NPWT resulted in successful closure of 86% of infected abdominal wounds with exposed prosthetic mesh. Patient hospital LOS (except those with PG mesh), operative procedures and readmissions were decreased during NPWT compared with treatment prior to NPWT. Future multi-site prospective, controlled studies would provide a strong evidence base from which treatment decisions could be made in the management of these challenging and costly cases.
C1 [Baharestani, Mona Mylene] James H Quillen Vet Affairs Med Ctr, Johnson City, TN USA.
   [Baharestani, Mona Mylene] E Tennessee State Univ, Quillen Coll Med, Dept Surg, Johnson City, TN 37614 USA.
   [Gabriel, Allen] SW Med Grp Plast Surg, Vancouver, WA USA.
   [Gabriel, Allen] Loma Linda Univ, Med Ctr, Dept Plast Surg, Loma Linda, CA USA.
C3 East Tennessee State University; Loma Linda University
RP Baharestani, MM (通讯作者)，James H Quillen Vet Affairs Med Ctr, Johnson City, TN USA.
EM mona.baharestani@va.gov
RI Gabriel, Allen/AFK-3548-2022
CR AGRAWAL S, 2008, EUR J VASC ENDOVASC, V15, P1
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NR 35
TC 33
Z9 36
U1 0
U2 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2011
VL 8
IS 2
BP 118
EP 125
DI 10.1111/j.1742-481X.2010.00756.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 735YW
UT WOS:000288457700005
PM 21176107
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Frykberg, R
   Martin, E
   Tallis, A
   Tierney, E
AF Frykberg, Robert
   Martin, Erin
   Tallis, Arthur
   Tierney, Edward
TI A case history of multimodal therapy in healing a complicated diabetic
   foot wound: negative pressure, dermal replacement and pulsed radio
   frequency energy therapies
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Complex wound; Diabetic foot; Multimodal therapies
ID CELL-PROLIFERATION INDUCTION; MECHANISMS; CLOSURE
AB Advanced multimodal therapies are being used with increasing frequency in the management of difficult or complex wounds. Although the primary goal remains to expedite complete healing, secondary goals include avoidance of superimposed infection, repeated hospitalisations and subsequent amputations. We describe a case involving a limb- and life-threatening necrotising infection in a diabetic patient in which we successfully applied negative pressure wound therapy, dermal replacement therapy and pulsed radio frequency energy to achieve definitive healing. Further study is warranted to elucidate the most effective combinations of such therapies to promote healing of similarly complex wounds.
C1 [Frykberg, Robert; Martin, Erin; Tallis, Arthur; Tierney, Edward] Carl T Hayden VA Med Ctr, Phoenix, AZ 85012 USA.
RP Frykberg, R (通讯作者)，Carl T Hayden VA Med Ctr, 650 E Indian Sch Rd, Phoenix, AZ 85012 USA.
EM Robert.frykberg@va.gov
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
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NR 26
TC 13
Z9 13
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2011
VL 8
IS 2
BP 132
EP 139
DI 10.1111/j.1742-481X.2010.00759.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 735YW
UT WOS:000288457700007
PM 21348945
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hutton, DW
   Sheehan, P
AF Hutton, David W.
   Sheehan, Peter
TI Comparative effectiveness of the SNaP™ Wound Care System
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cost and cost analysis; Diabetic foot ulcers; Negative pressure wound
   therapy; SNaP system; Wound care
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; RANDOMIZED
   CONTROLLED-TRIAL; THERAPY; MULTICENTER; DRESSINGS; COSTS
AB Diabetic lower extremity wounds cause substantial burden to healthcare systems, costing tens of thousands of dollars per episode. Negative pressure wound therapy (NPWT) devices have been shown to be cost-effective at treating these wounds, but the traditional devices use bulky electrical pumps that require a durable medical equipment rental-based procurement process. The Spiracur SNaP (TM) Wound Care System is an ultraportable NPWT system that does not use an electric pump and is fully disposable. It has superior healing compared to standard of care with modern dressings and comparable healing to traditional NPWT devices while giving patients greater mobility and giving clinicians a simpler procurement process. We used a mathematical model to analyse the costs of the SNaP (TM) system and compare them to standard of care and electrically powered NPWT devices. When compared to standard of care, the SNaP (TM) system saves over $9000 per wound treated and more than doubles the number of patients healed. The SNaP system has similar healing time to powered NPWT devices, but saves $2300 in Medicare payments or $2800 for private payers per wound treated. Our analysis shows that the SNaP (TM) system could save substantial treatment costs in addition to allowing patients greater freedom and mobility.
C1 [Hutton, David W.] Univ Michigan, Sch Publ Hlth, Dept Hlth Management & Policy, Ann Arbor, MI 48109 USA.
   [Sheehan, Peter] Sheehan Hlth Management Consulting, New York, NY USA.
C3 University of Michigan System; University of Michigan
RP Hutton, DW (通讯作者)，Univ Michigan, Sch Publ Hlth, Dept Hlth Management & Policy, Ann Arbor, MI 48109 USA.
EM dwhutton@umich.edu
OI Hutton, David/0000-0001-9677-1632
FU Spiracur, Inc.
FX DH has received sponsorship of this research from Spiracur, Inc. PS is a
   consultant for Spiracur.
CR [Anonymous], 2009, RED BOOK PHARM FUND
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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   *CTR MED MED SERV, LCD NEG PRESS WOUND
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   VAC THERAPY EC VALUE
   SNAP WOUND CARE SYST
NR 33
TC 12
Z9 12
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2011
VL 8
IS 2
BP 196
EP 205
DI 10.1111/j.1742-481X.2011.00775.x
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 735YW
UT WOS:000288457700015
PM 21385320
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Assenza, M
   Cozza, V
   Sacco, E
   Clementi, I
   Tarantino, B
   Passafiume, F
   Valesini, L
   Bartolucci, P
   Modini, C
AF Assenza, M.
   Cozza, V.
   Sacco, E.
   Clementi, I.
   Tarantino, B.
   Passafiume, F.
   Valesini, L.
   Bartolucci, P.
   Modini, C.
TI VAC (Vacuum Assisted Closure) treatment in Fournier's gangrene: personal
   experience and literature review
SO CLINICA TERAPEUTICA
LA English
DT Article
DE critically ill patient; fournier's gangrene; infection; necrotizing
   fasciitis; perineum; vacuum assisted closure (VAC)
ID NECROTIZING FASCIITIS; MANAGEMENT; THERAPY; DISEASE; DEVICE
AB Introduction. Fournier's gangrene (FG) is a rapidly developing necrotizing fasciitis that originates in genital and perineal region. The mortality rate is high and requires prompt diagnosis, antibiotic treatment and extensive necrosectomy with derivative colostomy. Vacuum Assisted Closure (VAC) is a wound care system of paramount importance in the treatment of complex wounds, including the perineum.
   Materials and Methods. We evaluated 6 cases of FG (males, mean age: 54.6 yrs) of the last 3 years (February 2008-August 2010). All patients were diabetics. We used intravenous antibiotic treatment and early surgical debridement with colostomy, followed by immediate positioning of a VAC device (NP 125-200 mmHg). The dressing changes were done every 3-4 days. Hyperbaric oxygen therapy (HBOT) was given only to one patient. Microbiological etiology was assessed by multiple cultures to tailor the antimicrobial treatment.
   Results. The VAC therapy reduces the number of dressings and the hospital length of stay (LOS), in agreement with the literature; in one of the cases a secondary reconstructive surgical intervention was possible. The colostomy was reversed in all patients within 3 months.
   Conclusions. Negative pressure is a time saving device, reducing days of hospitalization, patient's discomfort and number of medications. The possibility of a early reconstructive surgery improves significantly quality of life. Clin Ter 2011; 162(1):e1-e5
C1 [Assenza, M.; Sacco, E.; Clementi, I.; Tarantino, B.; Valesini, L.; Bartolucci, P.; Modini, C.] Univ Roma La Sapienza, Policlin Umberto 1, Dept Emergency, Rome, Italy.
   [Cozza, V.; Passafiume, F.] Univ Roma La Sapienza, Policlin Umberto 1, Dept Gen Surg, Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome; Sapienza
   University Rome; University Hospital Sapienza Rome
RP Assenza, M (通讯作者)，Via Demetriade 58, I-00178 Rome, Italy.
EM marco.assenza@uniroma1.it
RI ; ASSENZA, Marco/LLK-2745-2024
OI Cozza, Valerio/0000-0003-3863-5485; ASSENZA, Marco/0000-0002-0400-5410
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NR 25
TC 36
Z9 45
U1 0
U2 5
PU SOC EDITRICE UNIV
PI ROME
PA VIA G B MORGAGNI 1, ROME, 10061, ITALY
SN 0009-9074
J9 CLIN TER
JI Clin. Ter.
PD JAN-FEB
PY 2011
VL 162
IS 1
BP E1
EP E5
PG 5
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 736GB
UT WOS:000288477800011
PM 21448535
DA 2026-07-24
ER
PT J
AU Herr, M
   Grabein, B
   Palm, HG
   Efinger, K
   Riesner, HJ
   Friemert, B
   Willy, C
AF Herr, M.
   Grabein, B.
   Palm, H. -G.
   Efinger, K.
   Riesner, H. -J.
   Friemert, B.
   Willy, C.
TI Necrotizing fasciitis
SO UNFALLCHIRURG
LA German
DT Article
DE Necrotizing fasciitis; Necrotizing soft tissue infection; Streptococcus;
   Vacuum-assisted closure; Wound care
ID SOFT-TISSUE INFECTIONS; STREPTOCOCCUS-PYOGENES DISEASE; LABORATORY RISK
   INDICATOR; GROUP-A STREPTOCOCCUS; GANGRENE; EUROPE; SCORE
AB Necrotizing fasciitis belongs to a group of complicated soft tissue infections that can be even life threatening. Despite growing knowledge about its etiology, predictors, and the clinical progression, the mortality remains at a high level with 20%. A relevant reduction can be achieved only by an early diagnosis followed by consistent therapy. The clinical findings in about 75% of the cases are pain out of proportion, edema and tenderness, blisters, and erythema. It is elementary to differentiate a necrotizing or a non-necrotizing soft tissue infection early. In uncertain cases it can be necessary to perform a surgical exploration to confirm the diagnosis. The histopathologic characteristics are the fascial necrosis, vasculitis, thrombosis of perforating veins, the presence of the disease-causing bacteria as well as inflammatory cells like macrophages and polymorphonuclear granulocytes. Secondly, both the cutis and the muscle can be affected. In many cases there is a disproportion of the degree of local and systemic symptoms. Depending on the infectious agents there are two main types: type I is a polymicrobial infection and type II is a more invasive, serious, and fulminant monomicrobial infection mostly caused by group A Streptococcus pyogenes.
   Invasive, severe forms of streptococcal infections seem to occur more often in recent years. Multimodal and interdisciplinary therapy should be based on radical surgical d,bridement, systemic antibiotic therapy as well as enhanced intensive care therapy, which is sometimes combined with immunoglobulins (in streptococcal or staphylococcal infections) or hyperbaric oxygen therapy (HBOT, in clostridial infections). For wound care of extensive soft tissue defects vacuum-assisted closure has shown its benefit.
C1 [Willy, C.] Bundeswehrkrankenhaus Ulm, Chirurg Zentrum, D-89081 Ulm, Germany.
   [Herr, M.; Riesner, H. -J.; Friemert, B.] Bundeswehrkrankenhaus Ulm, Klin Unfallchirurg & Orthopadie, D-89081 Ulm, Germany.
   [Grabein, B.] Klinikum Univ Munchen, Klin Mikrobiol & Krankenhaushyg KMH, Munich, Germany.
   [Efinger, K.] Bundeswehrkrankenhaus Ulm, Abt Radiol Diagnost, D-89081 Ulm, Germany.
C3 Ulm University; Military Hospital Ulm; Ulm University; Military Hospital
   Ulm; University of Munich; Ulm University; Military Hospital Ulm
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Ulm, Chirurg Zentrum, Oberer Eselsberg 40, D-89081 Ulm, Germany.
EM ChristianWilly@Bundeswehr.org
RI /AAJ-3174-2021
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NR 31
TC 29
Z9 33
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD MAR
PY 2011
VL 114
IS 3
BP 197
EP +
DI 10.1007/s00113-010-1893-6
PG 18
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 737ET
UT WOS:000288552600006
PM 21373930
DA 2026-07-24
ER
PT J
AU Dietz, UA
   Spor, L
   Germer, CT
AF Dietz, U. A.
   Spor, L.
   Germer, C. -T.
TI Management of mesh-related infections
SO CHIRURG
LA German
DT Article
DE Hernia; Surgical mesh; Antibiotic prophylaxis; Infection;
   Vacuum-assisted closure
ID VENTRAL HERNIA REPAIR; INCISIONAL HERNIAS; CLASSIFICATION;
   COMPLICATIONS; METAANALYSIS
AB Infections of an implanted hernia mesh are a major challenge. The incidence of mesh infections after incisional hernia repair is about 1% for endoscopic techniques and can be more than 15% in open techniques. Intraoperative mesh contamination is considered to be the primary cause. All woven or knitted hernia meshes have recesses where bacteria may adhere and establish colonies. The bacterial spectrum for mesh infection includes skin pathogens, such as Staphylococcus aureus (including MRSA), Streptococcus spp., as well as E. coli, Enterococcus and Mycobacteria. The therapy approach needs to be tailored to the morphological findings and the treatment for uncomplicated phlegmon is broad spectrum antibiotic therapy. If there is encapsulated fluid accumulation, CT-controlled drainage and daily infusion of antiseptics via the drain is a good option. For dermal necrosis, mesh fistula, exposed mesh or enterocutaneous fistula, a precise CT evaluation is necessary to tailor the operation. Vacuum systems are gaining increased acceptance in conditioning the local findings. For most patients the therapeutic concept will be based on individual decisions. If parts of a formerly infected mesh remain in the patient, a lifelong follow-up is necessary.
C1 [Dietz, U. A.; Spor, L.; Germer, C. -T.] Univ Klinikum Wurzburg, Klin & Poliklin Allgemein Viszeral Gefass & Kinde, D-97080 Wurzburg, Germany.
C3 University of Wurzburg
RP Dietz, UA (通讯作者)，Univ Klinikum Wurzburg, Klin & Poliklin Allgemein Viszeral Gefass & Kinde, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany.
EM dietz_u@chirurgie.uni-wuerzburg.de
CR Aguilar B, 2010, J LAPAROENDOSC ADV S, V20, P249, DOI 10.1089/lap.2009.0274
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NR 30
TC 21
Z9 25
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-4722
J9 CHIRURG
JI Chirurg
PD MAR
PY 2011
VL 82
IS 3
BP 208
EP +
DI 10.1007/s00104-010-2013-4
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 737GZ
UT WOS:000288558400003
PM 21327906
DA 2026-07-24
ER
PT J
AU Dastouri, P
   Helm, DL
   Scherer, SS
   Pietramaggiori, G
   Younan, G
   Orgill, DP
AF Dastouri, Pouya
   Helm, Douglas L.
   Scherer, Saja S.
   Pietramaggiori, Giorgio
   Younan, George
   Orgill, Dennis P.
TI Waveform Modulation of Negative-Pressure Wound Therapy in the Murine
   Model
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 95th Annual Clinical Congress of the American-College-of-Surgeons/64th
   Annual Sessions of the Owen H Wangensteen Forum on Fundamental Surgical
   Problems
CY OCT 11-15, 2009
CL Chicago, IL
SP Amer Coll Surg
ID VACUUM-ASSISTED CLOSURE; CELL; ANGIOGENESIS; FORCES; SKIN; VEGF; STRETCH
AB Background: Negative-pressure wound therapy applied with a porous foam interface has been shown to accelerate granulation-tissue formation when a cyclic application mode of suction is applied, but the optimal waveform has not been determined. The authors hypothesized that changes in the suction waveform applied to wounds would modulate the biological response of granulation tissue formation.
   Methods: A vacuum-assisted closure device (Kinetic Concepts, Inc., San Antonio, Texas) was applied to full-thickness wounds in 48 male diabetic mice (C57BL/KsJ-Lepr db), which were treated with six different waveforms: square waveforms of 125 mmHg of suction for 2 minutes, alternating with 50 mmHg of suction for 2 minutes, 5 minutes, or 10 minutes; triangular waveform with a 7-minute period oscillating between 50 and 125 mmHg; and static suction at 125 mmHg or static suction at 0 mmHg (occlusive dressing). Wounds were quantitatively evaluated for granulation tissue thickness as well as the number of proliferating cells and the number of blood vessels of the newly formed granulation tissue.
   Results: At 7 days, the continuous and triangular waveforms induced the thickest granulation tissue, with high rates of cellular proliferation and blood vessel counts compared with square wave and occlusive dressing control wounds. Decreasing square waveform frequency significantly increased granulation tissue thickness, cellular proliferation, and blood vessel counts.
   Conclusions: Waveform modulation has a significant effect on granulation tissue formation, angiogenesis, and cellular proliferation in excisional wounds in diabetic mice. The rapid change in pressure seen in our square wave model may be detrimental to granulation tissue formation. (Plast. Reconstr. Surg. 127: 1460, 2011.)
C1 [Orgill, Dennis P.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
   Hop Cantonal Univ Geneva, Div Plast Surg, Geneva, Switzerland.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; University of Geneva
RP Orgill, DP (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI ; Orgill, Dennis/H-7596-2019; PIETRAMAGGIORI, Giorgio/HJA-1920-2022
OI Younan, George/0000-0001-8502-4850; Orgill, Dennis/0000-0002-8279-7310; 
CR Azuma N, 2000, J VASC SURG, V32, P789, DOI 10.1067/mva.2000.107989
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NR 19
TC 30
Z9 34
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR
PY 2011
VL 127
IS 4
BP 1460
EP 1466
DI 10.1097/PRS.0b013e31820a63cb
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 741CH
UT WOS:000288840200008
PM 21460654
DA 2026-07-24
ER
PT J
AU Fries, CA
   Jeffery, SLA
   Kay, AR
AF Fries, C. A.
   Jeffery, S. L. A.
   Kay, A. R.
TI Topical negative pressure and military wounds-A review of the evidence
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE Topical negative pressure; Military wounds; Trauma; Debridement
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; THERAPY; MANAGEMENT
AB Background: Topical negative pressure (TNP) has been used as a method of wound management for some years. Use of TNP is accepted best practice at Role 4. There are advocates of using TNP after initial wound surgery at Role 3 or 2E. The evidence to support forward use of TNP is not comprehensive, especially when considering this narrow cohort of patients and injury pattern. It is the aim of this review to evaluate the current evidence for the use of TNP in all wounds, and to find what evidence there is that may be applicable to military wounds.
   Methods: A literature search of Cinahl, Embase, Medline, ProQuest and the Cochrane Library was conducted; references were cross-referenced. All Randomised Controlled Trials (RCTs) were included in all languages over a comprehensive time period. An interim review was conducted by the Wound Management Working Group of the Academic Department of Military Surgery and Trauma. A further literature review was conducted to find all papers relating to the use of TNP on military wounds.
   Results: 17 reports were reviewed relating to 14 studies including 662 patients. Of these 131 were reported to have had traumatic injuries. Significant results were reported with respect to time to wound healing, patient comfort and reduction in wound volumes. Bacterial load was not affected, in the 3 trials which commented on this, but in 1 there was a significant reduction in wound infections in the TNP group. Several of the trials were small, methodology was not consistent therefore no meta-analysis was possible. 2 papers were found describing case series of military patients being treated with TNP.
   Conclusions: There is very little published evidence in the form of RCTs to support the use of TNP in the acute traumatic military setting. This review supports the requirement for further investigation to evaluate whether this method of wound management has a place forward of Role 4. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Fries, C. A.; Jeffery, S. L. A.] Selly Oak Hosp, Dept Burns & Plast Surg, Birmingham B29 6JD, W Midlands, England.
   [Kay, A. R.] Frenchay Hosp, Burns Ctr, Bristol BS16 1LE, Avon, England.
RP Fries, CA (通讯作者)，Flat 2,190 Harborne Rd, Birmingham B15 3JJ, W Midlands, England.
EM antonfries@gmail.com
RI jeffery, steven/A-5207-2013; Fries, Charles/LZG-4990-2025
OI jeffery, steven/0000-0001-6587-5412; 
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Calhoun JH, 2008, CLIN ORTHOP RELAT R, V466, P1356, DOI 10.1007/s11999-008-0212-9
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   Etoz A, 2007, WOUNDS, V19, P250
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   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   Joseph E, 2000, WOUNDS, V12, P60
   Leininger BE, 2006, J TRAUMA, V61, P1207, DOI 10.1097/01.ta.0000241150.15342.da
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
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   MORYKWAS MJ, 2007, ANN PLAST SURG, V38, P563
   MORYKWAS MJ, 2007, ANN PLAST SURG, V38, P553
   Mouës CM, 2007, J PLAST RECONSTR AES, V60, P672, DOI 10.1016/j.bjps.2006.01.041
   Moues C M, 2005, J Wound Care, V14, P224
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Peinemann F, 2008, BMC MED RES METHODOL, V8, DOI 10.1186/1471-2288-8-41
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
NR 24
TC 17
Z9 19
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD MAY
PY 2011
VL 42
IS 5
BP 436
EP 440
DI 10.1016/j.injury.2010.02.027
PG 5
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 743XQ
UT WOS:000289053200002
PM 20362982
DA 2026-07-24
ER
PT J
AU Bluman, EM
   Ficke, JR
   Covey, DC
AF Bluman, Eric M.
   Ficke, James R.
   Covey, Dana C.
TI War Wounds of the Foot and Ankle: Causes, Characteristics, and Initial
   Management
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE Battlefield injuries; Explosive weaponry; Lower extremity injuries;
   Negative pressure wound therapy
ID RED-CROSS; TRAUMATIC AMPUTATION; LEAD-INTOXICATION; BLAST INJURIES;
   TECHNIQUE TIP; BALLISTICS; CLASSIFICATION; RESUSCITATION; EXPLOSIONS;
   TERRORISM
AB There are many challenges inherent in caring for battlefield injuries to the foot and ankle. Optimal treatment for these injuries continues to change overtime. Newer techniques in the management of massive soft tissue and bony wounds will help to restore the best possible function. These include early damage control surgery, modern limb salvage techniques, and SAWD. The current wars in Iraq and Afghanistan will continue to provide a stimulus for advances in the treatment of high-energy, complex musculoskeletal trauma.
C1 [Bluman, Eric M.] Brigham & Womens Hosp, Dept Orthoped, Foot & Ankle Serv, Boston, MA 02115 USA.
   [Bluman, Eric M.] Harvard Univ, Sch Med, Boston, MA USA.
   [Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
   [Covey, Dana C.] USN, Med Ctr, Dept Orthopaed Surg, San Diego, CA 92134 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard Medical School; Brooke
   Army Medical Center; United States Department of Defense; United States
   Army; United States Department of Defense; United States Navy
RP Bluman, EM (通讯作者)，Brigham Foot & Ankle Ctr Faulkner, 1153 Ctr St,Suite 56, Boston, MA 02130 USA.
EM ebluman@partners.org
RI Bluman, Eric M/K-5849-2019
OI Bluman, Eric M/0000-0002-3848-1677; Covey, Dana/0000-0002-4023-6304
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NR 51
TC 20
Z9 28
U1 0
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
EI 1558-1934
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 1
EP 21
DI 10.1016/j.fcl.2009.11.004
PG 21
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 745TK
UT WOS:000289189200002
PM 20189114
DA 2026-07-24
ER
PT J
AU Bjarnason, T
   Montgomery, A
   Hlebowicz, J
   Lindstedt, S
   Petersson, U
AF Bjarnason, Thordur
   Montgomery, Agneta
   Hlebowicz, Joanna
   Lindstedt, Sandra
   Petersson, Ulf
TI Pressure at the Bowel Surface during Topical Negative Pressure Therapy
   of the Open Abdomen: An Experimental Study in a Porcine Model
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; FASCIAL
   CLOSURE; INTRAABDOMINAL HYPERTENSION; ENTEROCUTANEOUS FISTULAS;
   INTERNATIONAL-CONFERENCE; TEMPORARY CLOSURE; VENTRAL HERNIA; WOUND
   CONTROL; MANAGEMENT
AB Background Topical negative pressure (TNP) therapy is increasingly used in open abdomen management. It is not known to what extent this pressure propagates through the dressing to the bowel surface, potentially increasing the risk of bowel fistula formation. The present study in a porcine model was designed to evaluate pressure propagation.
   Methods A commercially available TNP therapy system (ABThera/VAC) was applied in six pigs after laparotomy. Pressure sensors were placed in predetermined positions in the dressing and in the abdominal cavity and the pressure was registered at TNP settings of -50, -75, -100, -125, and -150 mmHg. Next, after infusing 200 ml of saline into the abdomen through a catheter, the amount of fluid drained through the system during 10 min of TNP therapy was registered. Finally, pressure was measured above and below eight layers of paraffin gauzes during TNP therapy.
   Results Observed pressure within the outer two foams and the foam of the visceral protective layer correlated with preset TNP. The median pressure at the bowel surface was between -2 and -10 mmHg, regardless of preset TNP. Median fluid drainage was 95% of the infused fluid at -75 mmHg and 124% at -150 mmHg. Paraffin gauzes had a limited isolating effect, reducing the pressure by 13% in median.
   Conclusions Negative pressure reaching the bowel surface during TNP therapy with the ABThera system is limited for all TNP levels. Reduced therapy pressure does not lead to reduced pressure at the bowel surface. The system drains the abdominal cavity completely of fluid. Paraffin gauzes are of limited value as a means of pressure isolation.
C1 [Bjarnason, Thordur; Montgomery, Agneta; Petersson, Ulf] Lund Univ, Skane Univ Hosp, Dept Surg, S-20502 Malmo, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, Skane Univ Hosp, S-20502 Malmo, Sweden.
   [Lindstedt, Sandra] Lund Univ, Dept Thorac Surg, Skane Univ Hosp, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Bjarnason, T (通讯作者)，Lund Univ, Skane Univ Hosp, Dept Surg, S-20502 Malmo, Sweden.
EM thordur.bjarnason@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473
FU Einar and Inga Nilsson Foundation for Surgical Research at the
   Department of Surgery in Malmo; Region of Skane Research grants; KCI
FX The study was supported by grants from the Einar and Inga Nilsson
   Foundation for Surgical Research at the Department of Surgery in Malmo
   and by the Region of Skane Research grants. U. P. received an
   unrestricted (unconditional) research grant from KCI in 2008. The grant
   was not used for this study.
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NR 26
TC 25
Z9 27
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD APR
PY 2011
VL 35
IS 4
BP 917
EP 923
DI 10.1007/s00268-010-0937-y
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 745YW
UT WOS:000289208600034
PM 21222123
DA 2026-07-24
ER
PT J
AU Subotic, U
   Kluwe, W
   Oesch, V
AF Subotic, Ulrike
   Kluwe, Wolfram
   Oesch, Valerie
TI Community-Associated Methicillin-Resistant Staphylococcus
   Aureus-Infected Chronic Scalp Wound With Exposed Dura in a
   10-Year-Old Boy: Vacuum-Assisted Closure Is a Feasible Option: Case
   Report
SO NEUROSURGERY
LA English
DT Article
DE Dura; GranuFoam Silver; MRSA; Pediatric; VAC; Vacuum-assisted closure
ID MANAGEMENT
AB BACKGROUND AND IMPORTANCE: Since the introduction of vacuum-assisted closure (VAC) in 1997, it has been used successfully in treating difficult wounds, including spinal wounds and wounds in pediatric patients. There are no reports on VAC therapy in pediatric patients on the scalp, especially with exposed dura. This report describes a 10-year-old boy with a chronic wound of the scalp with exposed dura after multiple neurosurgical interventions who was treated successfully with VAC.
   CLINICAL PRESENTATION: A 10-year-old mentally disabled boy with Apert syndrome suffered from a chronic wound with community-associated methicillin-resistant Staphylococcus aureus (MRSA) infection after multiple neurosurgeon operations. For wound closure, VAC therapy was initiated on the bony defect with exposed dura. The wound healed successfully, and the MRSA disappeared.
   CONCLUSION: The aims of VAC therapy are formation of new granulation tissue, wound cleansing, and bacterial clearance. In this case, the VAC device was excellent for temporary coverage of the defect and for wound cleaning, and it allowed a thick bed of granulation tissue to form over the dura, even with minimal constant negative pressure. The application and management were feasible even in a mentally disabled child. With this experience, we are encouraged to use the VAC device in difficult wounds, even in the head and neck area in children, and to bring this treatment into the outpatient clinic.
C1 [Subotic, Ulrike] Univ Zurich, Childrens Hosp, CH-8032 Zurich, Switzerland.
   [Kluwe, Wolfram] Asklepios Hosp, St Augustin, Germany.
   [Oesch, Valerie] Univ Bern, Childrens Hosp, Bern, Switzerland.
C3 University of Zurich; University Children's Hospital Zurich; University
   of Bern; University Hospital of Bern
RP Subotic, U (通讯作者)，Univ Zurich, Childrens Hosp, Steinwiesstr 75, CH-8032 Zurich, Switzerland.
EM subotic18@gmx.net
OI Subotic, Ulrike/0000-0002-1383-1036
CR AMBROSIO A, 2005, VAC GRANUOFOAM SILVE
   Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
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   Donovan DJ, 2006, NEUROSURGERY S2, V58
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   Khan MAA, 2010, J PLAST RECONSTR AES, V63, P2168, DOI 10.1016/j.bjps.2010.03.017
   Lopez G, 2008, J PEDIATR SURG, V43, P2202, DOI 10.1016/j.jpedsurg.2008.08.067
   Ploumis A, 2008, J SPINAL DISORD TECH, V21, P320, DOI 10.1097/BSD.0b013e318141f99d
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NR 11
TC 16
Z9 22
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-396X
J9 NEUROSURGERY
JI Neurosurgery
PD MAY
PY 2011
VL 68
IS 5
BP E1481
EP E1483
DI 10.1227/NEU.0b013e318210c7fb
PG 3
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 746GE
UT WOS:000289230300006
PM 21307788
DA 2026-07-24
ER
PT J
AU Mouës, CM
   Heule, F
   Hovius, SER
AF Moues, C. M.
   Heule, F.
   Hovius, S. E. R.
TI A review of topical negative pressure therapy in wound healing:
   sufficient evidence?
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Review
DE Topical negative pressure therapy; Surgical wounds; Mechanism of action
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; THICKNESS
   SKIN-GRAFTS; DIABETIC FOOT ULCERS; SUBATMOSPHERIC PRESSURE; FASCIAL
   CLOSURE; OPEN ABDOMEN; SEALING-TECHNIQUE; MANAGEMENT; PROGRESSION
AB BACKGROUND: Topical negative pressure (TNP) therapy has become a useful adjunct in the management of various types of wounds. However, the TNP system still has characteristics of a "black box" with uncertain efficacy for many users. We extensively examined the effectiveness of TNP therapy reported in research studies.
   DATA SOURCES: A database search was undertaken, and over 400 peer-reviewed articles related to the use of TNP therapy (animal, human, and in vitro studies) were identified.
   CONCLUSIONS: Almost all encountered studies were related to the use of the commercial VAC device (KCI Medical, United States). Mechanisms of action that can be attributed to TNP therapy are an increase in blood flow, the promotion of angiogenesis, a reduction of wound surface area in certain types of wounds, a modulation of the inhibitory contents in wound fluid, and the induction of cell proliferation. Edema reduction and bacterial clearance, mechanisms that were attributed to TNP therapy, were not proven in basic research. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Moues, C. M.; Hovius, S. E. R.] Erasmus Univ, Med Ctr, Dept Plast Reconstruct & Hand Surg, NL-3000 DR Rotterdam, Netherlands.
   [Heule, F.] Erasmus Univ, Med Ctr, Dept Dermatol, NL-3000 DR Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC
RP Mouës, CM (通讯作者)，Erasmus Univ, Med Ctr, Dept Plast Reconstruct & Hand Surg, POB 1738, NL-3000 DR Rotterdam, Netherlands.
EM c.moues@erasmusmc.nl
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NR 92
TC 142
Z9 178
U1 0
U2 47
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD APR
PY 2011
VL 201
IS 4
BP 544
EP 556
DI 10.1016/j.amjsurg.2010.04.029
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 747HU
UT WOS:000289311700022
PM 21421104
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Ingemansson, R
   Malmsjö, M
AF Lindstedt, Sandra
   Ingemansson, Richard
   Malmsjo, Malin
TI Sternum wound contraction and distension during negative pressure wound
   therapy when using a rigid disc to prevent heart and lung rupture
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS
AB Background: There are increasing reports of deaths and serious complications associated with the use of negative pressure wound therapy (NPWT), of which right ventricular heart rupture is the most devastating. The use of a rigid barrier has been suggested to offer protection against this lethal complication by preventing the heart from being drawn up against the sharp edges of the sternum. The aim of the present study was to determine whether a rigid barrier can be safely inserted over the heart with regard to the sternum wound edge movement.
   Methods: Sternotomy wounds were created in eight pigs. The wounds were treated with NPWT at -40, -70, -120 and -170 mmHg in the presence and absence of a rigid barrier between the heart and the edges of the sternum. Wound contraction upon NPWT application, and wound distension under mechanical traction to draw apart the edges of the sternotomy were evaluated.
   Results: Wound contraction resulting from NPWT was similar with and without the rigid barrier. When mechanical traction was applied to a NPWT treated sternum wound, the sternal edges were pulled apart. Wound distension upon traction was similar in the presence and absence of a the rigid barrier during NPWT.
   Conclusions: A rigid barrier can safely be inserted between the heart and the edges of the sternum to protect the heart and lungs from rupture during NPWT. The sternum wound edge is stabilized equally well with as without the rigid barrier during NPWT.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Lindstedt, Sandra; Ingemansson, Richard; Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
   [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University
RP Lindstedt, S (通讯作者)，Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
EM sandra.lindstedt@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Ingemansson, Richard/0000-0001-7623-8953; Lindstedt,
   Sandra/0000-0003-4484-6473; Maljö, Malin/0000-0001-9849-9599
FU Swedish Medical Research Council; Lund University Faculty of Medicine;
   Swedish Government; Lund University Hospital; Swedish Medical
   Association; Royal Physiographic Society in Lund; Ake Wiberg Foundation;
   Anders Otto Sward Foundation/Ulrika Eklund Foundation; Magn Bergvall
   Foundation; Crafoord Foundation; Anna-Lisa and Sven-Erik Nilsson
   Foundation; Jeansson Foundation; Swedish Heart-Lung Foundation; Anna and
   Edvin Berger's Foundation; Marta Lundqvist Foundation; Lars Hierta's
   Memorial Foundation
FX This study was supported by the Swedish Medical Research Council, Lund
   University Faculty of Medicine, the Swedish Government Grant for
   Clinical Research, Lund University Hospital Research Grants, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the Ake
   Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika Eklund
   Foundation, the Magn Bergvall Foundation, the Crafoord Foundation, the
   Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeansson Foundation, the
   Swedish Heart-Lung Foundation, Anna and Edvin Berger's Foundation, the
   Marta Lundqvist Foundation, and Lars Hierta's Memorial Foundation.
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NR 17
TC 4
Z9 4
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD MAR 30
PY 2011
VL 6
AR 42
DI 10.1186/1749-8090-6-42
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 747YA
UT WOS:000289356000001
PM 21450095
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Atlan, M
   Naouri, M
   Lorette, G
   Estève, E
   Zakine, G
AF Atlan, M.
   Naouri, M.
   Lorette, G.
   Esteve, E.
   Zakine, G.
TI Original treatment of constitutional painful callosities by surgical
   excision, collagen/elastin matrix (MatriDerm®) and split thickness skin
   graft secured by negative wound therapy
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Dermal substitute; Collagen-elastin matrix; Constitutionnal painful
   callosities; Palmoplantar keratodermia; Negative pressure wound therapy;
   Skin graft; High resolution ultrasound; Cutometer
ID TERM-FOLLOW-UP; PALMOPLANTAR KERATODERMA; DERMAL SUBSTITUTE; MANAGEMENT;
   SURGERY; INTEGRA; BURNS
AB Constitutional painful callosities is an unusual pathology, integrated in the frame of "palmoplantar keratodermia" (PPK). Lesions are located at areas of support of the sole. These lesions are painful and disable the normal walking. Treatments are suspensive and painkillers. We report our experience of a single surgical treatment: surgical excision, split thickness skin graft applied on a dermal substitute and secured by negative wound therapy. A 28-year-old patient, affected by this disease, has a desire of pregnancy but her treatment is highly teratogen. A year post-op, wounds were healed. The walk was possible with a relief of the pain, without any ulcerations. The surgical treatment by excision and graft or flaps was previously reported for PPK. The use of dermal substitute was never described for this indication. Dermal substitute compensate the thickness of the soft tissue defect and give an accurate quality of elasticity in this localisation. The negative wound therapy enhances the quality and shortens the length of graft taking, and the adhesion of the dermal substitute on his bed. (C) 2009 Elsevier Masson SAS. All rights reserved.
C1 [Atlan, M.; Zakine, G.] CHU Tours, Fac Med Francois Rabelais, Hop Trousseau, Serv Chirurg Plast Reconstructrice & Esthet, F-37044 Tours 9, France.
   [Naouri, M.; Lorette, G.; Esteve, E.] CHRU Tours, Serv Dermatol, F-37044 Tours 9, France.
C3 CHU Tours; CHU Tours
RP Atlan, M (通讯作者)，CHU Tours, Fac Med Francois Rabelais, Hop Trousseau, Serv Chirurg Plast Reconstructrice & Esthet, F-37044 Tours 9, France.
EM mike_atlan@hotmail.com
RI Atlan, Michael/M-5256-2013
CR Bédard MS, 2008, PEDIATR DERMATOL, V25, P223, DOI 10.1111/j.1525-1470.2008.00639.x
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NR 22
TC 6
Z9 7
U1 0
U2 5
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
EI 1768-319X
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD APR
PY 2011
VL 56
IS 2
BP 163
EP 169
DI 10.1016/j.anplas.2009.11.013
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 749JO
UT WOS:000289461700013
PM 21492759
DA 2026-07-24
ER
PT J
AU Schiestl, C
   Neuhaus, K
   Biedermann, T
   Böttcher-Haberzeth, S
   Reichmann, E
   Meuli, M
AF Schiestl, C.
   Neuhaus, K.
   Biedermann, T.
   Boettcher-Haberzeth, S.
   Reichmann, E.
   Meuli, M.
TI Novel Treatment for Massive Lower Extremity Avulsion Injuries in
   Children: Slow, but Effective with Good Cosmesis
SO EUROPEAN JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE avulsion injury; vacuum assisted closure system; integra dermal
   regeneration template; reconstructive surgery; children
ID DEGLOVING INJURIES; MANAGEMENT; INTEGRA; WOUNDS; SKIN
AB Background: Extended avulsion injuries are associated with significant loss of skin and subcutaneous fat, leaving the reconstructive surgeon with the challenge of substituting all tissues lost in the best possible way. We wanted to test whether the combined use of a Vacuum Assisted Closure system (VAC) and Integra Dermal Regeneration Template (IDRT) matched the required treatment profile encompassing initial control of infection, remodeling of body contours, and reconstruction of near normal skin.
   Materials and Methods: 4 children with massive lower extremity avulsion injuries were treated with early necrosectomy, VAC application for 3-5 weeks for wound cleansing and wound bed conditioning, subsequent implantation of IDRT, and finally autologous split thickness skin grafting (STSG) for definitive wound closure. Thereafter, a standard rehabilitation program was used. The key parameters of VAC and IDRT application, take rates of IDRT and STSG, complications, length of stay, and final outcome were recorded.
   Results: In all patients, early removal of necrosis and infection control was successfully achieved. Continuous VAC application fostered the formation of a several millimeters thick new tissue layer partly compensating for the lost hypodermis. IDRT implantation and subsequent STSG yielded take rates of nearly 100% and both functionally and cosmetically excellent long-term results. There were no major complications.
   Conclusion: The combination of VAC and IDRT in children with massive leg avulsion injuries is feasible, safe, and delivers high-quality long-term outcomes that appear to justify the multiple operative procedures, the long hospitalization times, and the comparatively high costs entailed.
C1 [Schiestl, C.; Neuhaus, K.; Meuli, M.] Univ Childrens Hosp Zurich, Pediat Burn Ctr, Dept Surg, CH-8032 Zurich, Switzerland.
   [Biedermann, T.; Boettcher-Haberzeth, S.; Reichmann, E.] Dept Surg, Tissue Biol Res Unit, Zurich, Switzerland.
C3 University Children's Hospital Zurich
RP Schiestl, C (通讯作者)，Univ Childrens Hosp Zurich, Pediat Burn Ctr, Dept Surg, Steinwiesstr 75, CH-8032 Zurich, Switzerland.
EM clemens.schiestl@kispi.uzh.ch
RI ; Böttcher, Sophie/JBS-3818-2023
OI Neuhaus, Kathrin/0000-0003-2438-1779; Böttcher,
   Sophie/0000-0002-7713-9807
CR [Anonymous], J TRAUMA
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NR 19
TC 30
Z9 33
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0939-7248
J9 EUR J PEDIATR SURG
JI Eur. J. Pediatr. Surg.
PD MAR
PY 2011
VL 21
IS 2
BP 106
EP 110
DI 10.1055/s-0030-1267234
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 750NL
UT WOS:000289554900008
PM 21157691
DA 2026-07-24
ER
PT J
AU Stremitzer, S
   Dal Borgo, A
   Wild, T
   Goetzinger, P
AF Stremitzer, Stefan
   Dal Borgo, Andrea
   Wild, Thomas
   Goetzinger, Peter
TI Successful bridging treatment and healing of enteric fistulae by
   vacuum-assisted closure (VAC) therapy and targeted drainage in patients
   with open abdomen
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Secondary peritonitis; Enteric fistula; VAC; Bridging therapy
ID TEMPORARY ABDOMINAL CLOSURE; ENTEROCUTANEOUS FISTULAS; GASTROINTESTINAL
   FISTULAS; SURGICAL-MANAGEMENT; SEVERE PERITONITIS; SYSTEM; EXPERIENCE;
   SEPSIS; LAPAROSTOMY; FAILURE
AB The object of this study was to investigate the bridging treatment of enteric fistulae by vacuum-assisted closure (VAC) therapy in patients with open abdomen.
   We retrospectively analyzed patients who have been treated between 1 January 2007 and 31 December 2008 at the intensive care unit of the Department of General Surgery, Medical University Vienna. Control of the fistula was established by VAC therapy to bridge the patients to the time of the fistula resection.
   In the period of investigation, we treated nine (six men/three women) patients suffering from enteric fistulae with VAC therapy. The median age of the patients was 48 (range, 37-67) years. The median duration of VAC therapy was 76 (range, 53-128) days. The median length of stay in the intensive care unit was 44 (range, 25-127) days. The median APACHE II score was 23 (range, 18-25). The predicted mortality was 40%; the actual mortality was 11% (one patient). Primary fascial closure was achieved after median 91 (range, 89-92) days in three patients (33%) and secondary fascial closure after median 292 (range, 252-546) days in another three patients (33%). Fistulae were cured with VAC (five patients, 56%) and surgical resection (three patients, 33%). None of the patients developed a refistulation at the time of follow-up.
   Control of enteric fistulae by VAC therapy can lead to spontaneous fistula closure and is associated with a low mortality.
C1 [Stremitzer, Stefan; Dal Borgo, Andrea; Wild, Thomas; Goetzinger, Peter] Med Univ Vienna, Dept Gen Surg, A-1090 Vienna, Austria.
C3 Medical University of Vienna
RP Stremitzer, S (通讯作者)，Med Univ Vienna, Dept Gen Surg, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM stefan.stremitzer@meduniwien.ac.at
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NR 26
TC 11
Z9 15
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-1958
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD MAY
PY 2011
VL 26
IS 5
BP 661
EP 666
DI 10.1007/s00384-010-1126-z
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 750QD
UT WOS:000289562200016
PM 21212963
DA 2026-07-24
ER
PT J
AU Borgquist, O
   Ingemansson, R
   Malmsjö, M
AF Borgquist, Ola
   Ingemansson, Richard
   Malmsjo, Malin
TI Individualizing the Use of Negative Pressure Wound Therapy for Optimal
   Wound Healing: A Focused Review of the Literature
SO OSTOMY WOUND MANAGEMENT
LA English
DT Review
DE literature review; negative pressure wound therapy; gauze; foam;
   pressure settings
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; PROSPECTIVE
   RANDOMIZED-TRIAL; IMPROVING GRAFT-SURVIVAL; SECURING SKIN-GRAFTS;
   ENDOTHELIAL-CELLS; GAUZE; PROGRESSION; ULCERS; TRANSDUCTION
AB Currently available research suggests that negative pressure wound therapy (NPWT) creates a moist wound healing environment, drains exudate, reduces tissue edema, contracts the wound edges, mechanically stimulates the wound bed, and influences blood perfusion at the wound edge, which may lead to angiogenesis and the formation of granulation tissue. Although no clear evidence is available that NPWT accelerates wound healing compared to other interventions or that one form of NPWT is better than another, preclinical research suggests that the most commonly used dressings, level of negative pressure, and application mode (continuous, intermittent, or variable) may not be optimal for all patients. To summarize available literature related to these NPWT choices, pertinent literature published between 2005 and 2010 was reviewed. Preclinical study results suggest that the maximal biological effect of NPWT at the wound edge often can be achieved at -80 mm Hg and that foam dressings may be advantageous for large defect wounds, whereas gauze dressings may be more suitable for smaller wounds or when scar formation or pain is a concern. Preclinical research results also suggest that intermittent or variable pressure application has a better effect on granulation tissue formation than continuous application. The variable pressure mode maintains a negative pressure environment at lower pressure settings without dramatic fluctuations inherent to intermittent (on-and-off) pressure. Prospective, controlled clinical studies are needed to compare NPWT to other advanced wound care protocols of care and to ascertain the effect of various NPWT methods and regimens on outcomes of care.
C1 [Borgquist, Ola; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Borgquist, Ola] Lund Univ, Dept Anesthesiol & Intens Care, Lund, Sweden.
   [Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
C3 Lund University; Lund University; Lund University; Lund University;
   Skane University Hospital
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Borgquist, Ola/AAO-6451-2020
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953
FU Swedish Medical Research Council; Lund University Faculty of Medicine;
   Swedish Government; Lund University Hospital; Swedish Medical
   Association; Royal Physiographic Society in Lund; Ake Wiberg Foundation;
   Anders Otto Sward Foundation/Ulrika Eklund Foundation; Magn Bergvall
   Foundation; Crafoord Foundation; Anna-Lisa and Sven-Erik Nilsson
   Foundation; Jeansson Foundation; Swedish Heart-Lung Foundation; Anna and
   Edvin Berger's Foundation; Marta Lundqvist Foundation; Lars Hierta's
   Memorial Foundation; Prospera (Fort Worth, TX)
FX The work was supported by the Swedish Medical Research Council, Lund
   University Faculty of Medicine, the Swedish Government Grant for
   Clinical Research, Lund University Hospital Research Grants, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the Ake
   Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika Eklund
   Foundation, the Magn Bergvall Foundation, the Crafoord Foundation, the
   Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeansson Foundation, the
   Swedish Heart-Lung Foundation, Anna and Edvin Berger's Foundation, the
   Marta Lundqvist Foundation, Lars Hierta's Memorial Foundation, and
   Prospera (Fort Worth, TX).
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NR 67
TC 41
Z9 52
U1 1
U2 17
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD APR
PY 2011
VL 57
IS 4
BP 44
EP +
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 752QO
UT WOS:000289707700013
PM 21512192
DA 2026-07-24
ER
PT J
AU Henry, SL
   Weinfeld, AB
   Sharma, SK
   Kelley, PK
AF Henry, Steven L.
   Weinfeld, Adam B.
   Sharma, Sanjay K.
   Kelley, Patrick K.
TI External Doppler Monitoring of Free Flaps through Negative Pressure
   Dressings
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE Free flap; monitoring; wound VAC
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS
AB The negative pressure dressing is a highly effective modality for coverage and bolstering of skin grafts in the early postoperative period. In the situation of a skin graft over a free flap, the surgeon might be inclined to avoid this modality out of concern that the dressing would deleteriously effect flap survival or impede flap monitoring. This case series supports the safety of the negative pressure dressing and demonstrates a technical modification that permits external Doppler monitoring of the flap through the dressing. Thus, this technique provides an ideal environment for skin graft healing while maintaining the ability to monitor the flap in a straightforward manner and also simplifies nursing care.
C1 [Henry, Steven L.; Weinfeld, Adam B.; Sharma, Sanjay K.; Kelley, Patrick K.] Dell Childrens Med Ctr Cent Texas, Univ Med Ctr Brackenridge, Seton Inst Reconstruct Plast Surg, Austin, TX USA.
RP Henry, SL (通讯作者)，1400 N IH 35,Ste 320, Austin, TX 78701 USA.
EM slhenry@seton.org
RI Sharma, Sanjeev Kumar/HTN-7624-2023
OI Sharma, Sanjeev Kumar/0000-0002-3273-0708
CR Bannasch H, 2008, MICROSURG, V28, P412, DOI 10.1002/micr.20512
   Hanasono MM, 2007, ANN PLAS SURG, V58, P573, DOI 10.1097/01.sap.0000237638.93453.66
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
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   Weinfeld AB, 2005, ANN PLAS SURG, V54, P178, DOI 10.1097/01.sap.0000143606.39693.3f
NR 6
TC 9
Z9 10
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD MAY
PY 2011
VL 27
IS 4
BP 215
EP 218
DI 10.1055/s-0031-1272962
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 753OL
UT WOS:000289788800002
PM 21337298
DA 2026-07-24
ER
PT J
AU Saadi, A
   Perentes, JY
   Gonzalez, M
   Tempia, AC
   Wang, YB
   Demartines, N
   Ris, HB
   Krueger, T
AF Saadi, Alend
   Perentes, Jean Yannis
   Gonzalez, Michel
   Tempia, Adrien Caliera
   Wang, Yabo
   Demartines, Nicolas
   Ris, Hans-Beat
   Krueger, Thorsten
TI Vacuum-Assisted Closure Device: A Useful Tool in the Management of
   Severe Intrathoracic Infections
SO ANNALS OF THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 46th Annual Meeting of the Society-of-Thoracic-Surgeons
CY JAN 25-27, 2010
CL Ft Lauderdale, FL
SP Soc Thorac Surg
ID POSTPNEUMONECTOMY EMPYEMA; ACCELERATED TREATMENT; NEGATIVE-PRESSURE;
   CLAGETT PROCEDURE; WOUND CONTROL; THERAPY; EXPERIENCE; SEPSIS
AB Background. This study is an evaluation of the vacuum-assisted closure (VAC) therapy for the treatment of severe intrathoracic infections complicating lung resection, esophageal surgery, viscera perforation, or necrotizing pleuropulmonary infections.
   Methods. We reviewed the medical records of all patients treated by intrathoracic VAC therapy between January 2005 and December 2008. All patients underwent surgical debridement-decortication and control of the underlying cause of infection such as treatment of bronchus stump insufficiency, resection of necrotic lung, or closure of esophageal or intestinal leaks. Surgery was followed by intrathoracic VAC therapy until the infection was controlled. The VAC dressings were changed under general anesthesia and the chest wall was temporarily closed after each dressing change. All patients received systemic antibiotic therapy.
   Results. Twenty-seven patients (15 male, median age 64 years) underwent intrathoracic VAC dressings for the management of postresectional empyema (n = 8) with and without bronchopleural fistula, necrotizing infections (n = 7), and intrathoracic gastrointestinal leaks (n = 12). The median length of VAC therapy was 22 days (range 5 to 66) and the median number of VAC changes per patient was 6 (range 2 to 16). In-hospital mortality was 19% (n = 5) and was not related to VAC therapy or intrathoracic infection. Control of intrathoracic infection and closure of the chest cavity was achieved in all surviving patients.
   Conclusions. Vacuum-assisted closure therapy is an efficient and safe adjunct to treat severe intrathoracic infections and may be a good alternative to the open window thoracostomy in selected patients. Long time intervals in between VAC changes and short course of therapy result in good patient acceptance. (Ann Thorac Surg 2011;91:1582-90) (C) 2011 by The Society of Thoracic Surgeons
C1 [Krueger, Thorsten] CHU Vaudois, Dept Thorac & Vasc Surg, Div Thorac & Vasc Surg, CH-1011 Lausanne, Switzerland.
   CHU Vaudois, Div Visceral Surg, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Krueger, T (通讯作者)，CHU Vaudois, Dept Thorac & Vasc Surg, Div Thorac & Vasc Surg, CH-1011 Lausanne, Switzerland.
EM thorsten.krueger@chuv.ch
RI ; Saadi, Alend/HGT-8854-2022; Krueger, Thorsten/AAK-1780-2021
OI gonzalez, michel/0000-0001-8705-4279; Saadi, Alend/0000-0002-4039-0811;
   Demartines, Nicolas/0000-0002-1530-3114; Perentes,
   Jean/0000-0001-7918-0793
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NR 28
TC 43
Z9 59
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD MAY
PY 2011
VL 91
IS 5
BP 1582
EP 1590
DI 10.1016/j.athoracsur.2011.01.018
PG 10
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 754EE
UT WOS:000289835000063
PM 21354551
DA 2026-07-24
ER
PT J
AU Gill, NA
   Hameed, A
   Sajjad, Y
   Ahmad, Z
   Mirza, MAR
AF Gill, Nauman Ahmad
   Hameed, Abdul
   Sajjad, Yawar
   Ahmad, Zeeshan
   Mirza, Mohammad Ali Rafique
TI "Homemade" Negative Pressure Wound Therapy: Treatment of Complex Wounds
   Under Challenging Conditions
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTION
AB Background. Complex wounds pose a challenge to the surgeons regarding coverage and reconstruction. Negative pressure wound therapy (NPWT) has become a widely accepted technology for managing such wounds. Despite the case reports suggesting excellent outcomes of commercially available NPWT systems, there is paucity of randomized, controlled trials. Homemade alternatives can be of great use in hospitals with limited resources if they are found to be effective for managing complex wounds. Objective. To determine the effectiveness of "homemade" NPWT for coverage of challenging and difficult wounds of different regions of the body with limited options for reconstruction. Methods. Forty-four patients with 51 complex wounds involving different parts of body were included in the study. After initial debridement, the patients were treated with NPWT to obtain a healthy granulating wound bed that could be covered with simple reconstruction (ie, skin graft). Results. The average number of dressing changes was 2.9 and the average duration from start of therapy until the wound was ready for coverage was 13 days. Forty-seven wounds were skin grafted and 3 wounds were covered with local turnover flaps. One post sternotomy wound healed by secondary intention. Conclusion. This simple "homemade" NPWT system is an effective technique for treating challenging wounds on various parts of the body.
C1 [Gill, Nauman Ahmad; Hameed, Abdul; Sajjad, Yawar; Ahmad, Zeeshan; Mirza, Mohammad Ali Rafique] Shaikh Zayed Hosp, Dept Plast & Reconstruct Surg, Fed Postgrad Med Inst, Lahore, Pakistan.
RP Gill, NA (通讯作者)，Shaikh Zayed Hosp, Dept Plast & Reconstruct Surg, Fed Postgrad Med Inst, Block D, Lahore, Pakistan.
EM naumangill22@yahoo.co.uk
RI Ahmad, Zeeshan/KIJ-6670-2024
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Neumeister MW, 2003, HAND CLIN, V19, P1, DOI 10.1016/S0749-0712(02)00141-5
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Rozen WM, 2008, J PLAST RECONSTR AES, V61, P334, DOI 10.1016/j.bjps.2007.01.064
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   Shalom A, 2008, ISR MED ASSOC J, V10, P613
   Tanaka K, 2006, J PLAST RECONSTR AES, V59, P835, DOI 10.1016/j.bjps.2005.10.020
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
NR 18
TC 12
Z9 14
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2011
VL 23
IS 4
BP 84
EP 92
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 755VR
UT WOS:000289968200003
PM 25881336
DA 2026-07-24
ER
PT J
AU Beno, M
   Martin, J
   Sager, P
AF Beno, M.
   Martin, J.
   Sager, P.
TI Vacuum assisted closure in vascular surgery
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE acute and chronic wounds; negative pressure wound therapy; vacuum
   assisted closure; peripheral arterial occlusive disease; infected graft
   material
ID PRESSURE
AB Background: Vacuum assisted closure (VAC - therapy) is a well established method in nearly all surgical disciplines. The aim is to present the efficiency of vacuum assisted closure in the treatment of acute and chronic wounds in patients admitted in the department of vascular surgery.
   Methods: Within the year 2008 there were 59 patients (44 men, 15 women) treated with VAC therapy in our Department of Vascular surgery (Landshut, Germany). VAC was used 22x (37.28 %) in therapy of ulcus cruris (venous, arterial, mixed genesis), 15x (25.42 %) in patients with diabetic foot syndrome, 12x (20.33 %) in secondary healing wounds and infected wounds, 5x (8.47 %) in wounds after several injuries and soft skin tissue infections and 5x (8.47 %) in wound infections connected with vascular graft infections after vascular revascularization.
   Results: VAC therapy seems to be very effective in the management of patients with venous ulcers, especially after a proper surgical treatment (100 %), patients with soft skin tissue infections (100 %) and secondary healing wounds (100 %) especially in combination with MESH - Grafting. In patients with diabetic foot syndrome (80 %) and peripheral arterial occlusive disease (72.7 %), an evaluation of peripheral blood perfusion and revascularization prior to VAC therapy is often necessary. Although VAC was used 5x in the therapy of infected vascular grafts, successful preservation of infected graft material was observed in only one case (infection of PTFE femoro-popliteal bypass graft).
   Conclusion: Vacuum assisted closure in vascular surgery proved to be simple and efficient method in therapy of acute and chronic wounds. The efficiency of VAC systems in therapy of infected graft material after revascularization needs further studies (Tab. 3, Ref. 10). Full Text in free PDF www.bmj.sk.
C1 [Beno, M.; Martin, J.; Sager, P.] Akad Lehrkrankenhaus TU Munchen, KKH Landshut Achdorf, Landshut, Germany.
RP Beno, M (通讯作者)，Akad Lehrkrankenhaus TU Munchen, KKH Landshut Achdorf, Achdorfer Weg 3, Landshut, Germany.
EM mbeno69@yahoo.com
CR Deva AK, 2000, MED J AUSTRALIA, V173, P128, DOI 10.5694/j.1326-5377.2000.tb125564.x
   Eneroth M, 2008, DIABETES-METAB RES, V24, pS76, DOI 10.1002/dmrr.852
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NR 10
TC 6
Z9 9
U1 0
U2 9
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2011
VL 112
IS 5
BP 249
EP 252
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 761TO
UT WOS:000290424100004
PM 21682077
DA 2026-07-24
ER
PT J
AU Arslan, E
   Ozturk, OG
   Aksoy, A
   Polat, G
AF Arslan, Emrah
   Ozturk, Ozlem Goruroglu
   Aksoy, Alper
   Polat, Gurbuz
TI Vacuum-assisted closure therapy leads to an increase in plasma
   fibronectin level
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Plasma fibronectin; Vacuum-assisted closure; Wound healing
ID SUBATMOSPHERIC PRESSURE; RATS; WOUNDS
AB An extensive research has been performed to investigate the mechanisms of action by which the application of subatmospheric pressure to wounds increases the rate of healing. Increased blood flow with vacuum-assisted closure (VAC) use is the most popular aspect. Fibronectin, which is an adhesion molecule, has several functional domains mediating chemotaxis, adhesion and migration. This is thereby involved in differentiation, proliferation, inflammation and thus in wound healing. In this study, plasma fibronectin levels were measured before and after VAC in patients with wounds. The results showed that there was an increase in pre- and post-VAC levels of plasma fibronectin. This statistically significant increase could be another explanation of how VAC therapy promotes wound healing.
C1 [Arslan, Emrah] Canakkale Onsekiz Mart Univ Plast & Reconstruct S, Canakkale, Turkey.
   [Ozturk, Ozlem Goruroglu; Polat, Gurbuz] Mersin Univ Biochem, Mersin, Turkey.
   [Aksoy, Alper] Bursa Konur Hastanesi Plast & Reconstruct Surg, Bursa, Turkey.
C3 Canakkale Onsekiz Mart University; Mersin University; Acibadem Hospitals
   Group
RP Arslan, E (通讯作者)，Canakkale Onsekiz Mart Univ Plast & Reconstruct S, Arastirma & Uygulama Hastanesi, TR-17100 Kepez Canakkale, Turkey.
EM deohus@gmail.com
RI goruroglu ozturk, ozlem/E-9568-2018; /D-1289-2017; ARSLAN,
   Emrah/OLP-5615-2025; POLAT, Gurbuz/N-8024-2015
OI goruroglu ozturk, ozlem/0000-0001-9325-5296; 
CR Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
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NR 21
TC 15
Z9 19
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2011
VL 8
IS 3
BP 224
EP 228
DI 10.1111/j.1742-481X.2011.00772.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 762OI
UT WOS:000290488900004
PM 21401882
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Saziye, K
   Cikirikcioglu, M
   Ilker, U
   Afksendyios, K
AF Saziye, Karaca
   Cikirikcioglu, Mustafa
   Ilker, Uckay
   Afksendyios, Kalangos
TI Comparison of vacuum-assisted closure device and conservative treatment
   for fasciotomy wound healing in ischaemia-reperfusion syndrome:
   preliminary results
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Compartment syndrome; Fasciotomy closure; Fasciotomy treatment; VAC;
   Vascular surgery
ID NEGATIVE-PRESSURE; DIABETIC FOOT; MANAGEMENT; THERAPY; PROMOTE; TRIAL;
   RISK; SKIN
AB Ischaemia-reperfusion syndrome (IRS) is a condition that may require early fasciotomy. In the past, fasciotomies ultimately required prolonged hospitalisation. Vacuum-assisted closure (VAC) therapy system is an innovative method which promotes wound healing by reducing wound oedema, increasing microcirculation, and stimulation of granulation tissue. The aim of this retrospective study was to compare the VAC treatment with the conservative treatment of the fasciotomy wound until definitive surgical closure. The researchers retrospectively identified 15 patients, 3 females and 12 males, with a mean age of 69 years, who underwent a fasciotomy between January 2003 and December 2009 at the University Hospital of Geneva. All of the fasciotomies performed on the patients were on account of IRS. Seven patients were subjected to wound treatment using the VAC-system device and eight patients underwent treatment through the usual conservative method. The data were analysed by comparing the operative wound size, length of time for wound closure and duration of hospital stay in both groups. The number of days after fasciotomy until surgical wound closure in the VAC-system group (n = 7) ranged from 8 to 13 days with a mean of 11 days. The wound size at the day of closure was decreased in length by a mean of 58% (range 29-67%) and in diameter by a mean of 56% (range 33-75%). The duration of hospital stay for this group ranged from 12 to 18 days with a mean of 14 days. No signs of infections were observed and no re-operation was required after first closure. In the conservative group (n = 8), the time to wound closure ranged between 12 and 20 days with a mean of 15 days. The wound size was decreased in length by a mean of 40% (range 32-53%) and in diameter by a mean 46% (range 30-70%). The mean duration of hospital stay was 18 center dot 5 days. Three of the patients in the conservative treatment group manifested wound infection during the course of the treatment. VAC device could be a new standard for treatment of fasciotomy wound. VAC therapy is a recent innovation and becoming more and more a necessary complementary therapy to hasten wound healing. In our preliminary study, the VAC-system device showed significantly reduction of the wound size, decreased tissue oedema, duration of hospital days and improvement of granulation tissue.
C1 [Saziye, Karaca; Cikirikcioglu, Mustafa; Afksendyios, Kalangos] Univ Hosp Geneva, Dept Cardiovasc Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Ilker, Uckay] Univ Hosp Geneva, Dept Infectiol, CH-1211 Geneva 14, Switzerland.
C3 University of Geneva; University of Geneva
RP Saziye, K (通讯作者)，Univ Hosp Geneva, Dept Cardiovasc Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM saziye.karaca@hcuge.ch
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NR 38
TC 30
Z9 37
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2011
VL 8
IS 3
BP 229
EP 236
DI 10.1111/j.1742-481X.2011.00773.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 762OI
UT WOS:000290488900005
PM 21401883
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Eo, S
   Kim, Y
   Cho, S
AF Eo, SuRak
   Kim, YoongSoo
   Cho, SangHun
TI Vacuum-assisted closure improves the incorporation of artificial dermis
   in soft tissue defects: Terudermis® and Pelnac®
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Artificial dermal substitutes; Pelnac (R); Terudermis (R);
   Vacuum-assisted closure
ID SECURING SKIN-GRAFTS; NEGATIVE-PRESSURE DRESSINGS; CLINICAL-TRIAL;
   PENILE SHAFT; RECONSTRUCTION; THERAPY; BOLSTER; INTEGRA; DEVICE
AB As a dermal scaffold, artificial dermal substitutes allow the body to accomplish its own tissue regeneration through infiltration of cells and neovascularisation. However, they show not only rather lower take rates compared to autologous skin grafts alone, but they also require more time for sufficient vascular ingrowth to overlay the skin graft. To accelerate this overlaying, we applied vacuum-assisted closure negative-pressure settings over the artificial dermis: Terudermis (R) and Pelnac (R) grafts. Fourteen patients with complex tissue defects were treated, including bone exposure in two cases, tendon exposure in seven cases and soft tissue defects in five cases. Nine cases had combined wound infections. The time interval between the first artificial dermis graft and the second split-thickness skin graft over it was 7 center dot 64 days on average. Dermal substitutes took place completely in all cases and there were no graft failures.
C1 [Eo, SuRak; Cho, SangHun] DongGuk Univ Int Hosp, Dept Plast & Reconstruct Surg, Ilsan, South Korea.
   [Kim, YoongSoo] Kims Plast Surg Clin, Seoul, South Korea.
C3 Dongguk University
RP Eo, S (通讯作者)，DongGuk Univ Int Hosp, Dept Plast & Reconstruct Surg, 814 SikSa Dong, Goyang Si 410773, Gyeonggi Do, South Korea.
EM surakeo@yahoo.com
RI Eo, SuRak/JXM-4124-2024
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Suzuki S, 2000, BRIT J PLAST SURG, V53, P659, DOI 10.1054/bjps.2000.3426
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NR 39
TC 57
Z9 66
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2011
VL 8
IS 3
BP 261
EP 267
DI 10.1111/j.1742-481X.2011.00780.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 762OI
UT WOS:000290488900009
PM 21561535
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Caro, A
   Olona, C
   Jiménez, A
   Vadillo, J
   Feliu, F
   Vicente, V
AF Caro, Aleidis
   Olona, Carles
   Jimenez, Andrea
   Vadillo, Jordi
   Feliu, Francesc
   Vicente, Vicente
TI Treatment of the open abdomen with topical negative pressure therapy: a
   retrospective study of 46 cases
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal wound; Open abdomen; Topical negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMINAL WOUNDS; TEMPORARY CLOSURE;
   ENTEROCUTANEOUS FISTULA; LAPAROSTOMY; EXPERIENCE; MANAGEMENT; TRAUMA
AB The open abdomen is an ongoing challenge for professionals engaged in its treatment. The change in the integrity of the abdominal wall, the loss of fluids, heat and proteins and contamination of the wound are the main problems. The objective of this article is to describe our experience using the abdominal dressing vacuum-assisted closure therapy in treatment of the open abdomen. Since December 2006, all patients requiring treatment with the open abdomen technique have been treated with the abdominal dressing system and vacuum-assisted closure therapy (VAC (R) KCI, San Antonio, USA). The results obtained with this technique in non traumatic patients are analysed herein. The abdominal dressing system was used on 46 patients in the period between January 2006 and December 2009, with a mean 63 years old (29-80), with a gender distribution of 33 men (72%) and 13 women (28%). Closure of the abdominal wall was possible in 24 patients, 5 of which were primary in the recent postoperative phase, 5 had primary suture of the fascia and application of the supra-aponeurotic prosthesis and 14 had closure of the abdominal wall with a composite polytetrafluoroethylene (PTFE) and polypropylene mesh. Second intention closure took place in the remaining 22 patients (48%), as their conditions did not allow primary closure. The mean treatment time with abdominal dressing was 26 days (6-92) with an average of eight changes per patient. The abdominal dressing topical negative pressure system is a useful option for consideration in the event of needing to leaves the abdomen open. It stabilises the abdominal wall and quantifies and collects exudate from the wound, protects the intra-abdominal viscera and keeps the fascia intact and the cutaneous plane for subsequent closure of the wall.
C1 [Caro, Aleidis; Olona, Carles; Jimenez, Andrea; Vadillo, Jordi; Feliu, Francesc; Vicente, Vicente] Univ Rovira & Virgili, Univ Hosp Joan XXIII Tarragona, Gen Digest Surg Dept, Tarragona 43007, Spain.
C3 Universitat Rovira i Virgili
RP Caro, A (通讯作者)，Univ Rovira & Virgili, Univ Hosp Joan XXIII Tarragona, Gen Digest Surg Dept, Tarragona 43007, Spain.
EM dra5028@gmail.com
RI JimenezFranco, Andrea/PCR-9372-2025; Feliu, Francesc/ABF-5725-2021;
   Vicente, Vicente/L-6185-2019
OI Vicente, Vicente/0000-0002-4278-3264; Caro, Aleidis/0000-0001-6151-3879
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 23
TC 33
Z9 39
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2011
VL 8
IS 3
BP 274
EP 279
DI 10.1111/j.1742-481X.2011.00782.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 762OI
UT WOS:000290488900011
PM 21410648
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Wollina, U
   Meseg, A
   Weber, A
AF Wollina, Uwe
   Meseg, Antje
   Weber, Andreas
TI Use of a collagen-elastin matrix for hard to treat soft tissue defects
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Collagen-elastin matrix; deep soft tissue defects; dermal substitutes;
   mesh-graft transplantation; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; DERMAL SUBSTITUTE; MATRIDERM(R); WOUNDS; BURNS;
   GRAFTS; DEVICE
AB As deep soft tissue defects with exposed bone, cartilage or tendons are not suitable for wound closure with skin mesh grafts, other techniques are needed. We report on six patients, one female and five males, aged between 32 and 89 years, and deep soft tissue defects with exposed tendons, cartilage or bone. The aetiology of these defects was vascular (n = 3), tumour surgery (2), and post-traumatic (1). Wounds were treated with a collagen-elastin matrix applied above the exposed structures. In five patients, the procedure was combined with mesh graft transplantation in the same setting. Follow-up varied between 12 and 40 weeks. Wound healing was uncomplicated in all transplanted patients until first dressing change after 7 days. All but one transplant showed a 100% take rate and the transplant was stable within 10-14 days. A complete wound closure was also achieved without transplantation, but this took 8 weeks. No adverse effects were noted. There was no skin contracture of the skin grafts. Collagen-elastin matrix with split-thickness skin grafts is a useful tool in deep soft tissue. The time to heal can be reduced.
C1 [Wollina, Uwe; Meseg, Antje] Acad Teaching Hosp Dresden Friedrichstadt, Dept Dermatol & Allergol, D-01067 Dresden, Germany.
   [Weber, Andreas] Acad Teaching Hosp Dresden Friedrichstadt, Dept Orthopaed Surg, D-01067 Dresden, Germany.
C3 Technische Universitat Dresden; Municipal Hospital Dresden; Technische
   Universitat Dresden; Municipal Hospital Dresden
RP Wollina, U (通讯作者)，Acad Teaching Hosp Dresden Friedrichstadt, Dept Dermatol & Allergol, Friedrichstr 41, D-01067 Dresden, Germany.
EM wollina-uw@khdf.de
RI Wollina, Uwe/AAJ-9644-2020
OI Wollina, Uwe/0000-0001-5933-2913
CR Banwell P E, 2003, J Wound Care, V12, P22
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NR 22
TC 14
Z9 15
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2011
VL 8
IS 3
BP 291
EP 296
DI 10.1111/j.1742-481X.2011.00785.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 762OI
UT WOS:000290488900013
PM 21449935
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Luedders, DW
   Bohlmann, MK
   Hornemann, A
   Dittmer, C
   Diedrich, K
   Thill, M
AF Luedders, Doerte W.
   Bohlmann, Michael K.
   Hornemann, Amadeus
   Dittmer, Christine
   Diedrich, Klaus
   Thill, Marc
TI Successful application of vacuum-assisted closure therapy for treatment
   of mastitis-associated chronic breast wounds
SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS
LA English
DT Article
DE Breast; Mastitis; Surgery; Vacuum-assisted closure
ID TOPICAL NEGATIVE-PRESSURE; SALVAGE; RECONSTRUCTION; MANAGEMENT; DEVICE
AB Although non-puerperal mastitis is rare and its cause is rather unclear, the number of patients diagnosed with this defect is increasing. In some cases, standard therapy fails and it progresses to a chronic disease. Vacuum-assisted closure (VAC) therapy has shown good results in healing complex wounds.
   The goal of this study was to evaluate our experiences with VAC therapy and to answer the question whether or not should be accepted as an effective treatment in healing chronic wounds caused by non-puerperal mastitis. Retrospectively, we identified five patients with a non-puerperal mastitis chronic wound that was treated using VAC and report on their outcome.
   We reached both wound control and closure of the breast wounds in all patients.
   According to our findings, the VAC therapy can be considered when managing challenging breast wounds, particularly when other therapeutic options have failed. The role of VAC therapy as a primary therapeutic option has not yet been evaluated.
C1 [Luedders, Doerte W.; Bohlmann, Michael K.; Dittmer, Christine; Diedrich, Klaus; Thill, Marc] Univ Hosp Schleswig Holstein, Dept Obstet & Gynaecol, D-23538 Lubeck, Germany.
   [Hornemann, Amadeus] Univ Heidelberg, Univ Hosp Mannheim, Dept Obstet & Gynaecol, D-68167 Mannheim, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; Ruprecht
   Karls University Heidelberg
RP Luedders, DW (通讯作者)，Univ Hosp Schleswig Holstein, Dept Obstet & Gynaecol, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM doerte.luedders@uk-sh.de
CR Berghof S, 2008, SENOLOGIE, V5, P27
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NR 21
TC 9
Z9 11
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0932-0067
J9 ARCH GYNECOL OBSTET
JI Arch. Gynecol. Obstet.
PD JUN
PY 2011
VL 283
IS 6
BP 1357
EP 1362
DI 10.1007/s00404-010-1594-y
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 763DZ
UT WOS:000290536100028
PM 20652284
DA 2026-07-24
ER
PT J
AU Kobayashi, T
   Mikamo, A
   Kurazumi, H
   Suzuki, R
   Shirasawa, B
   Hamano, K
AF Kobayashi, Toshiro
   Mikamo, Akihito
   Kurazumi, Hiroshi
   Suzuki, Ryo
   Shirasawa, Bungo
   Hamano, Kimikazu
TI Secondary omental and pectoralis major double flap reconstruction
   following aggressive sternectomy for deep sternal wound infections after
   cardiac surgery
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DELAYED CLOSURE; MEDIASTINITIS; MODALITY
AB Background: Deep sternal wound infection after cardiac surgery carries high morbidity and mortality. Our strategy for deep sternal wound infection is aggressive strenal debridement followed by vacuum-assisted closure (VAC) therapy and omental-muscle flap reconstrucion. We describe this strategy and examine the outcome and long-term quality of life (QOL) it achieves.
   Methods: We retrospectively examined 16 patients treated for deep sternal wound infection between 2001 and 2007. The most recent nine patients were treated with total sternal resection followed by VAC therapy and secondary closure with omental-muscle flap reconstruction (recent group); whereas the former seven patients were treated with sternal preservation if possible, without VAC therapy, and four of these patients underwent primary closure (former group). We assessed long-term quality of life after DSWI by using the Short Form 36-Item Health Survey, Version 2 (SF36v2).
   Results: One patient died and four required further surgery for recurrence of deep sternal wound infection in the former group. The duration of treatment for deep sternal wound infection in the recent group was significantly shorter than that in previous group (63.4 +/- 54.1 days vs. 120.0 +/- 31.8 days, respectively; p = 0.039). Despite aggressive sternal resection, the QOL of patients treated for DSWI was only minimally compromised compared with age-, sex-, surgical procedures-matched patients without deep sternal wound infection.
   Conclusions: Aggressive sternal debridement followed by VAC therapy and secondary closure with an omental-muscle flap is effective for deep sternal wound infection. In this series, it resulted in a lower incidence of recurrent infection, shorter hospitalization, and it did not compromise long-term QOL greatly.
C1 [Hamano, Kimikazu] Yamaguchi Univ, Dept Surg, Div Cardiac Surg, Grad Sch Med, Yamaguchi 7558505, Japan.
   Yamaguchi Univ, Dept Clin Sci, Div Cardiac Surg, Grad Sch Med, Yamaguchi 7558505, Japan.
C3 Yamaguchi University; Yamaguchi University
RP Hamano, K (通讯作者)，Yamaguchi Univ, Dept Surg, Div Cardiac Surg, Grad Sch Med, 1-1-1 Minami Kogushi, Yamaguchi 7558505, Japan.
EM kimikazu@yamaguchi-u.ac.jp
FU Grants-in-Aid for Scientific Research [22591543] Funding Source: KAKEN
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NR 25
TC 26
Z9 30
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD APR 18
PY 2011
VL 6
AR 56
DI 10.1186/1749-8090-6-56
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 764XX
UT WOS:000290669100001
PM 21501461
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Dobson, MW
   Geisler, D
   Fazio, V
   Remzi, F
   Hull, T
   Vogel, J
AF Dobson, M. W.
   Geisler, D.
   Fazio, V.
   Remzi, F.
   Hull, T.
   Vogel, J.
TI Minimally invasive surgical wound infections: laparoscopic surgery
   decreases morbidity of surgical site infections and decreases the cost
   of wound care
SO COLORECTAL DISEASE
LA English
DT Article
DE Minimally invasive surgery; colorectal surgery; surgical site infections
ID NOSOCOMIAL INFECTIONS; HOSPITALIZATION; SURVEILLANCE
AB Aim
   The morbidity of surgical site infections (SSIs) were compared in patients who underwent open (OS) vs laparoscopic (LS) colorectal surgery.
   Method
   Data from 603 consecutive LS patients and 2246 consecutive OS patients were prospectively recorded. Morbidity of SSIs was assessed by the need for emergency department (ED) evaluation, subsequent hospital re-admission and re-operation. The cost of wound care was measured by the need for home healthcare, wound vacuum assisted closure (VAC) or independent patient wound care.
   Results
   SSIs were identified in 5.8% (n = 25) of LS patients and 4.8% (n = 65) of OS patients. ED evaluation for the infection was needed in 24% of the LS group and 42% of the OS group. Hospital re-admission was needed in one LS patient and in 52% OS patients. No LS patient needed re-operation compared with 12% of OS patients. HHC ($162/dressing change) was required in 63% of the OS group compared with 8% of LS group. A home wound VAC system ($107/day) was utilized in 12% of the OS patients but in none of the LS patients. Dressing changes were managed independently by the patient in 92% of the LS compared with 37% of the OS patients.
   Conclusion
   Laparoscopic colorectal surgery patients experience less morbidity when they develop SSIs incurring less cost compared with open colorectal surgery patients.
C1 [Dobson, M. W.; Geisler, D.; Fazio, V.; Remzi, F.; Hull, T.; Vogel, J.] Cleveland Clin Fdn, Dept Colon & Rectal Surg, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation
RP Dobson, MW (通讯作者)，2001 Vail Ave Suite 320, Charlotte, NC 28207 USA.
EM mdobsondo@hotmail.com
RI Remzi, Feza/AAE-6584-2022
CR [Anonymous], SURG INFECT
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NR 16
TC 29
Z9 36
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1462-8910
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JUL
PY 2011
VL 13
IS 7
BP 811
EP 815
DI 10.1111/j.1463-1318.2010.02302.x
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 774QY
UT WOS:000291402400024
PM 20456462
OA Bronze
DA 2026-07-24
ER
PT J
AU Mentula, P
AF Mentula, P.
TI Non-traumatic causes and the management of the open abdomen
SO MINERVA CHIRURGICA
LA English
DT Article
DE Decompression, surgical; Peritonitis; Pancreatitis, acute necrotizing;
   Surgical wound dehiscence; Aortic rupture
ID ABDOMINAL COMPARTMENT SYNDROME; DIRECT PERITONEAL RESUSCITATION;
   VACUUM-ASSISTED CLOSURE; PRIMARY FASCIAL CLOSURE; DELAYED PRIMARY
   CLOSURE; INTRAABDOMINAL HYPERTENSION; DAMAGE-CONTROL; SEPARATION
   TECHNIQUE; TRAUMA PATIENTS; WOUND CLOSURE
AB The open abdomen is increasingly used for the treatment and prevention of abdominal compartment syndrome. The leading non-traumatic conditions that may cause abdominal compartment syndrome requiring surgical decompression include secondary peritonitis, ruptured abdominal aortic aneurysm and severe acute pancreatitis. Patients may also end up with the open abdomen when the laparotomy wound cannot be closed without tension because of excessive visceral swelling. Also, surgical complications such as laparotomy wound dehiscence, may require temporary abdominal closure techniques. In critically ill surgical patients and in situations when second-look laparotomy is mandatory the open abdomen can be utilized in a preventive manner like in damage control trauma surgery. Underlying disease and the indication for the open abdomen significantly contributes to outcome of patient with open abdomen. Non-traumatic aetiology of the open abdomen is associated with lower likelihood of primary fascial closure and higher rate of open abdomen related complications compared with traumatic aetiology. A number of temporal abdominal closure techniques have been described. Ideally, temporal abdominal closure technique should prevent the development of recurrent abdominal compartment syndrome and facilitate later primary fascia closure with low complication rate. Although fascial closure rate varies between techniques, there are few evidence-based data to support one technique over another. However, recent evolution of temporary abdominal closure techniques have decreased the number of patients with frozen abdomen and reduced the need for planned hernia management. Highest fascial closure rates have been achieved with vacuum-assisted closure systems and systems that provide continuous fascial traction.
C1 Helsinki Univ Cent Hosp, Dept Gastrointestinal Surg, Helsinki 00029, Finland.
C3 University of Helsinki; Helsinki University Central Hospital
RP Mentula, P (通讯作者)，Helsinki Univ Cent Hosp, Dept Gastrointestinal Surg, POB 340, Helsinki 00029, Finland.
EM panu.mentula@hus.fi
RI Mentula, Panu/H-9025-2019
OI Mentula, Panu/0000-0002-6516-3797
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NR 70
TC 10
Z9 10
U1 0
U2 5
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4733
EI 1827-1626
J9 MINERVA CHIR
JI Minerva Chir.
PD APR
PY 2011
VL 66
IS 2
BP 153
EP 163
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 774TR
UT WOS:000291410000010
PM 21593717
DA 2026-07-24
ER
PT J
AU Hatch, QM
   Osterhout, LM
   Ashraf, A
   Podbielski, J
   Kozar, RA
   Wade, CE
   Holcomb, JB
   Cotton, BA
AF Hatch, Quinton M.
   Osterhout, Lisa M.
   Ashraf, Asma
   Podbielski, Jeanette
   Kozar, Rosemary A.
   Wade, Charles E.
   Holcomb, John B.
   Cotton, Bryan A.
TI Current Use of Damage-Control Laparotomy, Closure Rates, and Predictors
   of Early Fascial Closure at the First Take-Back
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Trauma; Laparotomy; Damage control; Temporary closure
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN;
   TRAUMA PATIENTS; WOUND CLOSURE; DEFINITIVE CLOSURE; EARLY COAGULOPATHY;
   TEMPORARY CLOSURE; VENTRAL HERNIA; MANAGEMENT
AB Background: Damage-control laparotomy (DCL) is a lifesaving technique but carries significant morbidity. If DCL is over used and the factors that predict early fascial closure have not been fully evaluated. The purpose of the current study was to determine (1) the current rate of DCL, (2) the percentage of DCLs that are closed at first take-back, and (3) possible physiologic and resuscitative parameters predicting early fascial closure.
   Methods: A retrospective review of all trauma laparotomies from a Level I trauma center between January 2004 and December 2008 was performed. Patients were excluded if they died before first take-back. Univariate and multivariate analyses were performed.
   Results: Nine hundred thirty patients were eligible, 278 (30%) underwent DCL, 36 excluded for death before first take-back. Of the remaining 242 DCL patients, 83 (34%) were closed at first take-back and 159 (66%) were not closed at first take-back. These two groups were similar in injury severity, demographics, and prehospital and emergency department fluids and vitals. Median emergency department international normalized ratio (INR; 1.13 vs. 1.29, p = 0.010), post-op INR (1.4 vs. 1.5, p = 0.028), 24-hour fluids (11.9 L vs. 15.5 L, p = 0.006), peak post-op intra-abdominal pressure (IAP; 15 vs. 18, p < 0.001), and mortality (1.2% vs. 8.2%, p = 0.027) were different between groups. Multivariate analysis noted vacuum-assisted closure at initial laparotomy (Odds ratio, 3.1; 95% confidence interval [CI], 1.42-6.63; p = 0.004) was an independent predictor of closure at first take-back. However, post-op INR (Odds ratio, 0.18; 95% CI, 0.03-0.97; p = 0.04) and post-op peak IAP (Odds ratio, 0.85; 95% CI, 0.76-0.95; p = 0.005) predicted failure to close fascia at first take-back.
   Conclusion: In similarly injured DCL patients, increased post-op INR and IAP predicted inability to achieve primary fascial closure on first take-back, while use of the vacuum-assisted closure was associated with increased likelihood of early fascial closure. At a busy academic Level I trauma center, the current rate of DCL among those undergoing emergent laparotomy is 30%. Whether this represents optimal use or overutilization of this technique still needs to be determined.
C1 Univ Texas Hlth Sci Ctr, Dept Surg, Houston, TX USA.
   Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, Houston, TX USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Texas System; University of Texas Health Science
   Center Houston
RP Cotton, BA (通讯作者)，UTHSCH CeTIR, 6410 Fannin St,1100-20 UPB, Houston, TX 77030 USA.
EM bryan.a.cotton@uth.tmc.edu
RI ; Cotton, Bryan/A-7107-2009; ashraf, Asma/LMN-0743-2024
OI holcomb, john/0000-0001-8312-9157; ashraf, Asma/0000-0001-7026-670X
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NR 59
TC 54
Z9 58
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD JUN
PY 2011
VL 70
IS 6
BP 1429
EP 1436
DI 10.1097/TA.0b013e31821b245a
PG 8
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 775QR
UT WOS:000291478500029
PM 21817981
DA 2026-07-24
ER
PT J
AU Lee, SY
   Niikura, T
   Miwa, M
   Sakai, Y
   Oe, K
   Fukazawa, T
   Kawakami, Y
   Kurosaka, M
AF Lee, Sang Yang
   Niikura, Takahiro
   Miwa, Masahiko
   Sakai, Yoshitada
   Oe, Keisuke
   Fukazawa, Takahiro
   Kawakami, Yohei
   Kurosaka, Masahiro
TI Negative Pressure Wound Therapy for the Treatment of Infected Wounds
   With Exposed Knee Joint After Patellar Fracture
SO ORTHOPEDICS
LA English
DT Article
C1 [Niikura, Takahiro] Kobe Univ, Grad Sch Med, Dept Orthoped Surg, Chuo Ku, Kobe, Hyogo 6500017, Japan.
C3 Kobe University
RP Niikura, T (通讯作者)，Kobe Univ, Grad Sch Med, Dept Orthoped Surg, Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan.
EM tniikura@med.kobe-u.ac.jp
RI Oe, Keisuke/MIO-9342-2025
OI Oe, Keisuke/0000-0001-9992-4550
NR 0
TC 11
Z9 17
U1 0
U2 1
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
J9 ORTHOPEDICS
JI Orthopedics
PD JUN
PY 2011
VL 34
IS 6
BP 478
EP 478
DI 10.3928/01477447-20110427-27
PG 1
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 776GG
UT WOS:000291521900031
PM 21667911
DA 2026-07-24
ER
PT J
AU Diefenbeck, M
   Mennenga, U
   Gückel, P
   Tiemann, AH
   Mückley, T
   Hofmann, GO
AF Diefenbeck, M.
   Mennenga, U.
   Gueckel, P.
   Tiemann, A. H.
   Mueckley, T.
   Hofmann, G. O.
TI Vacuum-Assisted Closure Therapy for the Treatment of Skin and
   Soft-Tissue Infections. Are Wound Specimens of Use in Planning Secondary
   Wound Closure?
SO ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
LA German
DT Article
DE skin and soft tissue infection (SSTI); vacuum-assisted closure (VAC);
   serial debridements
ID SEALING-TECHNIQUE; OPEN FRACTURES; MANAGEMENT; INSTILLATION; INJURIES;
   COVERAGE; TRIAL; BONE
AB Aim: Vacuum-assisted closure is used frequently for the treatment of skin and soft-tissue infections (SSTI) of the extremities. After debridement and repeated VAC dressing changes, the wounds are closed by secondary suture, split-thickness skin grafts or local flaps. However, no objective parameters describe the time point for secondary wound closure. Our thesis was that negative microbiological results from wound specimens can indicate the time for secondary wound closure.
   Patients and Methods: 24 patients with SSTI of the extremities were treated by serial debridements and VAC therapy and analysed prospectively. Debridements were repeated until the wounds were macroscopically free from signs of infection (good granulation/no necrosis). During each revision specimens were taken for microbiological analysis. Moreover, number of revisions, bacterial cultures, type of wound closure and wound status after 3 years and 5 months on average after the last surgery were analysed.
   Results: 6.3 revisions on average were performed until secondary wound closure was possible. In spite of the absence of macroscopic infection, bacteria were still found in tissue samples from 14 of 24 wounds. 6 wounds were free of bacteria for the first time right before wound closure, 3 wounds had become negative during the treatment. After 3.4 years on average, the wounds of all 18 patients available for examination had healed well and were free from signs of infection.
   Conclusion: Vacuum-assisted closure resulted in clean, good granulating wounds without necrosis. However, in more than half of the wounds bacteria persisted. This bacterial load had no correlation to wound healing and outcome after over 3 years. In conclusion, microbiological tissue samples are not suitable as indicator for the time point of secondary wound closure in SSTI.
C1 [Diefenbeck, M.; Mueckley, T.; Hofmann, G. O.] Univ Jena, Klin Unfall Hand & Wiederherstellungschirurg, D-07747 Jena, Germany.
   [Mennenga, U.; Tiemann, A. H.; Hofmann, G. O.] BG Kliniken Bergmannstrost Halle Saale, Klin Unfall & Wiederherstellungschirurg, Halle, Germany.
   [Gueckel, P.] Exquit, Software Solut, Munich, Germany.
C3 Friedrich Schiller University of Jena
RP Diefenbeck, M (通讯作者)，Univ Jena, Klin Unfall Hand & Wiederherstellungschirurg, Erlanger Allee 101, D-07747 Jena, Germany.
EM michael.diefenbeck@med.uni-jena.de
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NR 28
TC 9
Z9 10
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1864-6697
J9 Z ORTHOP UNFALLCHIR
JI Z. Orthop. Unfallchir.
PD JUN
PY 2011
VL 149
IS 3
BP 324
EP 329
DI 10.1055/s-0030-1250694
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 778ST
UT WOS:000291726700011
PM 21305454
DA 2026-07-24
ER
PT J
AU Diefenbeck, M
   Mennenga, U
   Gückel, P
   Tiemann, AH
   Mückley, T
   Hofmann, GO
AF Diefenbeck, M.
   Mennenga, U.
   Gueckel, P.
   Tiemann, A. H.
   Mueckley, T.
   Hofmann, G. O.
TI Vacuum-Assisted Closure Therapy for the Treatment of Acute Postoperative
   Osteomyelitis
SO ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
LA German
DT Article
DE acute posttraumatic/postoperative osteomyelitis; vacuum-assisted closure
   (VAC); serial debridements; osteitis; osteomyelitis
ID GENTAMICIN-PMMA-BEADS; SOFT-TISSUE INJURY; NOSOCOMIAL INFECTIONS;
   SEALING-TECHNIQUE; WOUND THERAPY; IMPLANTS; ALCOHOL; SURGERY; GERMANY;
   TRIAL
AB Aim: Vacuum-assisted closure is used frequently for the treatment of posttraumatic osteomyelitis of the extremities. After debridement and repeated VAC dressing changes, the wounds are closed by secondary suture, split-thickness skin grafts or local flaps. However, no objective parameters describe the time point for secondary wound closure. Our thesis was that negative microbiological results from bone specimens can indicate the time for secondary wound closure. Moreover, treatment course and clinical outcome after 3.4 years should be compared to those of other surgical approaches for acute postoperative osteomyelitis from the literature.
   Patients and Methods: 43 patients with acute postoperative osteomyelitis of the extremities and the pelvis were treated by serial bone and soft tissue debridements and VAC therapy and analysed prospectively. Debridements were repeated until the wounds were macroscopically free from signs of infection (good granulation/no necrosis). During each revision a bone specimen was taken for microbiological analysis. Number of revisions, bacterial cultures, type of wound closure and recurrence of infection after 3 years and 5 months on average after the last surgery was analysed.
   Results: 9.8 debridements on average were performed until eradication of infection and secondary wound closure. Despite the absence of macroscopic infection, bacteria were still found in bone samples from 15 of 43 patients. Three biopsies were free of bacteria for the first time right before wound closure, 25 samples had become negative during the treatment. Six recurrences (19.3%) were noted after 3.4 years on average. Four patients from the group of negative bone biopsies (19%) and two patients from the group of persisting bacteria before secondary closure (20%) had a recurrence of infection.
   Conclusion: In about one third of the bone biopsies bacteria persisted. This bacterial load had no correlation to wound healing and rate of recurrence after over 3 years. In conclusion, microbiological bone samples are not suitable as an indicator for the time point of secondary wound closure. Compared to other treatment options in acute postoperative osteomyelitis from the literature (especially implantation of local antibiotics), no advantage of vacuum-assisted closure could be shown concerning number of debridements and rate of recurrences.
C1 [Diefenbeck, M.; Mueckley, T.; Hofmann, G. O.] Univ Jena, Klin Unfall Hand & Wiederherstellungschirurg, D-07747 Jena, Germany.
   [Mennenga, U.; Tiemann, A. H.; Hofmann, G. O.] BG Kliniken Bergmannstrost, Klin Unfall & Wiederherstellungschirurg, Halle, Germany.
   [Gueckel, P.] Exquit Software Solut, Munich, Germany.
C3 Friedrich Schiller University of Jena
RP Diefenbeck, M (通讯作者)，Univ Jena, Klin Unfall Hand & Wiederherstellungschirurg, Erlanger Allee 101, D-07747 Jena, Germany.
EM michael.diefenbeck@med.uni-jena.de
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NR 30
TC 17
Z9 23
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1864-6697
J9 Z ORTHOP UNFALLCHIR
JI Z. Orthop. Unfallchir.
PD JUN
PY 2011
VL 149
IS 3
BP 336
EP 341
DI 10.1055/s-0030-1270952
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 778ST
UT WOS:000291726700013
PM 21526465
DA 2026-07-24
ER
PT J
AU Kurihara, C
   Nishimura, T
   Kinoshita, O
   Kawata, M
   Hisagi, M
   Kyo, S
   Ono, M
AF Kurihara, Chitaru
   Nishimura, Takashi
   Kinoshita, Osamu
   Kawata, Mitsuhiro
   Hisagi, Motoyuki
   Kyo, Shunei
   Ono, Minoru
TI Successful treatment of mediastinitis after ventricular assist device
   implantation with rerouting of the outflow vascular prosthesis
SO JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Ventricular assist device (VAD); Mediastinitis; Negative pressure wound
   therapy (NPWT); Rerouting
ID GUIDELINE; THERAPY
AB We report successful treatment of mediastinitis with rerouting of the outflow vascular prosthesis after bi-ventricular assist device (Bi-VAD) implantation. A 23 years-old male with fulminant myocarditis underwent VAD implantation. He required sternotomy three times. Mediastinitis developed after the third surgery, and negative pressure wound therapy (NPWT) with irrigation was applied. The infection was well controlled, but after 3 months of NPWT hemorrhage developed because of injury of the outflow vascular prosthesis in the anterior mediastinum. We rerouted the outflow vascular prosthesis to the descending aorta via the left thoracic cavity. After rerouting, artificial material was removed from the anterior mediastinum. The sternal wound healed completely after NPWT. Intractable mediastinitis after extra-corporeal VAD implantation may be treated with irrigation and NPWT, but there is a possibility of outflow graft injury. A sternal wound could be closed as a secondary healing process by rerouting the outflow vascular prosthesis.
C1 [Kurihara, Chitaru; Kinoshita, Osamu; Kawata, Mitsuhiro; Ono, Minoru] Univ Tokyo, Dept Cardiothorac Surg, Bunkyo Ku, Tokyo 1138655, Japan.
   [Nishimura, Takashi; Hisagi, Motoyuki; Kyo, Shunei] Univ Tokyo, Dept Therapeut Strategy Heart Failure, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo; University of Tokyo
RP Kurihara, C (通讯作者)，Univ Tokyo, Dept Cardiothorac Surg, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM baby_star_1207@yahoo.co.jp; takashin-tky@umin.ac.jp
FU Grants-in-Aid for Scientific Research [21249073] Funding Source: KAKEN
CR Holman WL, 2004, J HEART LUNG TRANSPL, V23, P1359, DOI 10.1016/j.healun.2003.09.025
   Kawata M, 2005, J VASC SURG, V42, P573, DOI 10.1016/j.jvs.2004.05.025
   Kawata M, 2005, ARTIF ORGANS, V29, P820, DOI 10.1111/j.1525-1594.2005.00135.x
   Kinoshita O, 2010, J ARTIF ORGANS, V13, P126, DOI 10.1007/s10047-010-0500-5
   Marggraf G, 1999, EUR J SURG, V163, P12
   Petzina R, 2010, EUR J CARDIO-THORAC, V38, P110, DOI 10.1016/j.ejcts.2010.01.028
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   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
NR 8
TC 9
Z9 9
U1 0
U2 0
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1434-7229
EI 1619-0904
J9 J ARTIF ORGANS
JI J. Artif. Organs
PD JUN
PY 2011
VL 14
IS 2
BP 155
EP 158
DI 10.1007/s10047-010-0550-8
PG 4
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA 778XU
UT WOS:000291743500010
PM 21286769
DA 2026-07-24
ER
PT J
AU Kawata, M
   Nishimura, T
   Hoshino, Y
   Kinoshita, O
   Hisagi, M
   Ando, M
   Morota, T
   Motomura, N
   Kyo, S
   Ono, M
AF Kawata, Mitsuhiro
   Nishimura, Takashi
   Hoshino, Yasuhiro
   Kinoshita, Osamu
   Hisagi, Motoyuki
   Ando, Masahiko
   Morota, Tetsuro
   Motomura, Noboru
   Kyo, Shunei
   Ono, Minoru
TI Negative pressure wound therapy for left ventricular assist
   device-related mediastinitis: two case reports
SO JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Negative pressure wound therapy; Left ventricular assist device;
   Mediastinitis; Quality of life
ID CLOSURE; INFECTIONS; SUPPORT
AB We report two cases of successful use of negative pressure wound therapy (NPWT) to control of left ventricular assist device (LVAD)-related mediastinitis. It is difficult to treat mediastinitis in patients who have undergone LVAD implantation, because it is impossible to remove the infected artificial materials from the mediastinal space. This report indicates that NPWT might become the preferred therapeutic option for control of mediastinitis in patients who have undergone LVAD implantation.
C1 [Kawata, Mitsuhiro; Nishimura, Takashi; Hoshino, Yasuhiro; Kinoshita, Osamu; Hisagi, Motoyuki; Ando, Masahiko; Morota, Tetsuro; Motomura, Noboru; Kyo, Shunei; Ono, Minoru] Univ Tokyo, Dept Cardiothorac Surg, Fac Med, Bunkyo Ku, Tokyo 1138654, Japan.
C3 University of Tokyo
RP Kawata, M (通讯作者)，Univ Tokyo, Dept Cardiothorac Surg, Fac Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138654, Japan.
EM mkawata-ths@umin.ac.jp; takashin-tky@umin.ac.jp
RI Motomura, Noboru/AAK-6000-2020
FU Grants-in-Aid for Scientific Research [21249073] Funding Source: KAKEN
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Kinoshita O, 2010, J ARTIF ORGANS, V13, P126, DOI 10.1007/s10047-010-0500-5
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Petzina R, 2010, J THORAC CARDIOV SUR, V140, P1133, DOI 10.1016/j.jtcvs.2010.06.063
   Petzina R, 2010, EUR J CARDIO-THORAC, V38, P110, DOI 10.1016/j.ejcts.2010.01.028
   Sinha P, 2000, CIRCULATION, V102, P194
   Zierer A, 2007, ANN THORAC SURG, V84, P515, DOI 10.1016/j.athoracsur.2007.03.085
NR 8
TC 12
Z9 12
U1 0
U2 0
PU SPRINGER TOKYO
PI TOKYO
PA 1-11-11 KUDAN-KITA, CHIYODA-KU, TOKYO, 102-0073, JAPAN
SN 1434-7229
J9 J ARTIF ORGANS
JI J. Artif. Organs
PD JUN
PY 2011
VL 14
IS 2
BP 159
EP 162
DI 10.1007/s10047-011-0555-y
PG 4
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA 778XU
UT WOS:000291743500011
PM 21347682
DA 2026-07-24
ER
PT J
AU Harrison, TM
   Stanley, BJ
   Sikarskie, JG
   Bohart, G
   Ames, NK
   Tomlian, J
   Marquardt, M
   Marcum, A
   Kiupel, M
   Sledge, D
   Agnew, D
AF Harrison, Tara M.
   Stanley, Bryden J.
   Sikarskie, James G.
   Bohart, George
   Ames, N. Kent
   Tomlian, Janice
   Marquardt, Mark
   Marcum, Annabel
   Kiupel, Matti
   Sledge, Dodd
   Agnew, Dalen
TI SURGICAL AMPUTATION OF A DIGIT AND VACUUM-ASSISTED-CLOSURE (VAC)
   MANAGEMENT IN A CASE OF OSTEOMYELITIS AND WOUND CARE IN AN EASTERN BLACK
   RHINOCEROS (DICEROS BICORNIS MICHAELI)
SO JOURNAL OF ZOO AND WILDLIFE MEDICINE
LA English
DT Article
DE Amputation; black rhinoceros; Diceros bicornis michaeli; MRSA;
   methicillin resistant Staphylococcus aureus; osteomyelitis;
   vacuum-assisted closure; VAC
ID CHRONIC LEG ULCERS; THE-ART TREATMENT; THERAPY
AB A 14-yr-old female eastern black rhinoceros (Diceros bicornis michaeli) presented with progressive suppurative osteomyelitis in her left hind lateral toe. beta-Hemolytic Streptococcus sp. was isolated. The animal was treated with multiple systemic antibiotics, and topical wound cleansing. Repeated debridements and nail trimmings were performed for 5 mo prior to electing amputation. The toe was surgically amputated under general anesthesia between the first and second phalanges. Analgesia was diffused into the wound topically via a catheter and elastomeric pump. The open amputation site was covered with adherent drapes and a negative-pressure wound therapy device provided vacuum-assisted closure (V.A.C.*) for 72 hr. Three months later this animal developed a deep dermal ulcer on the lateral aspect of the right hind limb, at the level of the stifle. Methicillin-resistant Staphylococcus aureus was isolated. The wound was managed by initial daily lavage, followed by I mo of V.A.C. therapy, with 72 hr between dressing changes. Clinically, this therapy expedited the formation of healthy granulation tissue and overall healing was accelerated. The animal tolerated the machine and bandage changes well via operant conditioning. The use of negative-pressure wound therapy appeared to shorten time to resolution of slow-healing wounds in black rhinoceros.
C1 [Harrison, Tara M.; Tomlian, Janice; Marquardt, Mark; Marcum, Annabel] Potter Pk Zoo, Lansing, MI 48912 USA.
   [Harrison, Tara M.; Stanley, Bryden J.; Sikarskie, James G.; Bohart, George; Ames, N. Kent] Michigan State Univ, Ctr Vet Clin, Coll Vet Med, E Lansing, MI 48824 USA.
   [Kiupel, Matti; Sledge, Dodd; Agnew, Dalen] Michigan State Univ, Diagnost Ctr Populat & Anim Hlth, E Lansing, MI 48910 USA.
C3 Michigan State University; Michigan State University
RP Harrison, TM (通讯作者)，Potter Pk Zoo, 1301 S Penn, Lansing, MI 48912 USA.
EM taramharrison@gmail.com
RI Kiupel, Matti/PII-4117-2026; Sledge, Dodd/PCS-0864-2025
OI Harrison, Tara/0000-0002-2072-5936
CR ADKESON M, 2007, J AM VET MED ASSOC, V8, P1240
   Ahmed M, 2007, J VASC SURG, V46, P614, DOI 10.1016/j.jvs.2006.12.092
   Ben-Amotz R, 2007, VET SURG, V36, P684, DOI 10.1111/j.1532-950X.2007.00321.x
   Coke Rob L., 2006, Journal of Herpetological Medicine and Surgery, V16, P102
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   Leffler M, 2010, J PLAST RECONSTR AES, V63, pE32, DOI 10.1016/j.bjps.2009.05.022
   Leininger BE, 2006, J TRAUMA, V61, P1207, DOI 10.1097/01.ta.0000241150.15342.da
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   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
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   Owen LJ, 2009, VET COMP ORTHOPAED, V22, P417, DOI 10.3415/VCOT-08-12-0123
   Pollak AN, 2008, J ORTHOP TRAUMA, V22, pS142, DOI 10.1097/BOT.0b013e318188e2a9
   Sibbald RG, 2008, INT WOUND J, V5, pIII, DOI 10.1111/j.1742-481X.2008.00473.x
   Turek D, 2009, Rozhl Chir, V88, P693
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 21
TC 19
Z9 24
U1 0
U2 7
PU AMER ASSOC ZOO VETERINARIANS
PI YULEE
PA 581705 WHITE OAK ROAD, YULEE, FL 32097 USA
SN 1042-7260
EI 1937-2825
J9 J ZOO WILDLIFE MED
JI J. Zoo Wildl. Med.
PD JUN
PY 2011
VL 42
IS 2
BP 317
EP 321
DI 10.1638/2010-0149.1
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 779DZ
UT WOS:000291759600019
PM 22946413
DA 2026-07-24
ER
PT J
AU Kakarala, K
   Richmon, JD
   Lin, DT
   Deschler, DG
AF Kakarala, Kiran
   Richmon, Jeremy D.
   Lin, Derrick T.
   Deschler, Daniel G.
TI Vacuum-Assisted Closure in Revision Free Flap Reconstruction
SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
LA English
DT Article
ID WOUND CONTROL; NECK WOUNDS; MANAGEMENT; SYSTEM; THERAPY; HEAD
C1 [Kakarala, Kiran; Lin, Derrick T.; Deschler, Daniel G.] Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Div Head & Neck Surg, Boston, MA 02114 USA.
   [Kakarala, Kiran; Lin, Derrick T.; Deschler, Daniel G.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
   [Richmon, Jeremy D.] Johns Hopkins Univ, Div Head & Neck Surg, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   Eye & Ear Infirmary; Harvard University; Harvard Medical School; Johns
   Hopkins University
RP Deschler, DG (通讯作者)，Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Div Head & Neck Surg, 243 Charles St, Boston, MA 02114 USA.
EM daniel_deschler@meei.harvard.edu
RI Richmon, Jeremy/ABI-4295-2020
OI Kakarala, Kiran/0000-0002-1003-8024; Richmon, Jeremy/0000-0002-6588-6549
CR Andrews BT, 2008, ANN OTO RHINOL LARYN, V117, P298, DOI 10.1177/000348940811700410
   Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bannasch H, 2008, MICROSURG, V28, P412, DOI 10.1002/micr.20512
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Dhir K, 2009, LARYNGOSCOPE, V119, P54, DOI 10.1002/lary.20000
   Flack S, 2008, J Wound Care, V17, P71
   Hanasono MM, 2007, ANN PLAS SURG, V58, P573, DOI 10.1097/01.sap.0000237638.93453.66
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Uygur F, 2008, INT WOUND J, V5, P50, DOI 10.1111/j.1742-481X.2007.00362.x
   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
NR 11
TC 11
Z9 11
U1 0
U2 4
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0886-4470
J9 ARCH OTOLARYNGOL
JI Arch. Otolaryngol. Head Neck Surg.
PD JUN
PY 2011
VL 137
IS 6
BP 622
EP 624
DI 10.1001/archoto.2011.74
PG 3
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA 780BJ
UT WOS:000291825900013
PM 21690516
DA 2026-07-24
ER
PT J
AU Wallin, AM
   Boström, L
   Ulfvarson, J
   Ottosson, C
AF Wallin, Ann-Mari
   Bostrom, Lennart
   Ulfvarson, Johanna
   Ottosson, Carin
TI Negative Pressure Wound Therapy - A Descriptive Study
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE negative pressure wound therapy; retrospective descriptive study; wound
   healing; wounds and injuries; comorbidity
ID CLOSURE; VACUUM; ULCERS
AB To address a persistent lack of evidence regarding the clinical outcomes of negative pressure wound therapy (NPWT) and identify which patient groups are most likely to benefit from NPWT, a retrospective, descriptive study was conducted to describe outcomes of this treatment modality when used in clinical practice. Charts from a consecutive series of 87 patients (median age 68 years, range 16 - 92 years) who received NPWT during a period of 24 months were abstracted to a statistical software file. Patient demographics, history, and comorbidity variables as well as treatment outcomes were obtained from the computerized in- and outpatient record system. Treatment outcomes were grouped as successful (goal of care was met) or not successful (goal of care was not met). Successful treatment was noted for a total of 62 patients (71%) with a median treatment time of 17 days. The proportion of patients with a successful outcome was significantly higher in patients with infectious, postoperative, and traumatic wounds than in patients with wounds related to peripheral vascular disease or pressure ulcers (P = 0.001). Treatment complications were observed in 18 patients (21%); five were related to infection. Quality-of-life concerns were noted as a reason for stopping treatment in four patients and equipment problems were recorded for two patients receiving NPWT in the home. This study confirms previous research that NPWT may be an effective and safe treatment method for acute wounds but further studies are needed to evaluate treatment efficacy and effectiveness in patients with peripheral vascular disease or pressure-induced wounds. Results also suggest that research protocols should include patient quality-of-life outcomes.
C1 [Wallin, Ann-Mari; Bostrom, Lennart] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Surg, S-11883 Stockholm, Sweden.
   [Ulfvarson, Johanna] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Neurobiol & Soc, S-11883 Stockholm, Sweden.
   [Ottosson, Carin] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Orthoped Surg, S-11883 Stockholm, Sweden.
C3 Karolinska Institutet; Sodersjukhuset Hospital; Karolinska Institutet;
   Sodersjukhuset Hospital; Sodersjukhuset Hospital; Karolinska Institutet
RP Wallin, AM (通讯作者)，Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Surg, S-11883 Stockholm, Sweden.
EM ann-mari.wallin@soder-sjukhuset.se
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NR 13
TC 6
Z9 7
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2011
VL 57
IS 6
BP 22
EP +
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 780GR
UT WOS:000291843000006
PM 21701045
DA 2026-07-24
ER
PT J
AU Leffler, M
   Derrick, KL
   McNulty, A
   Malsiner, C
   Dragu, A
   Horch, RE
AF Leffler, Mareike
   Derrick, Kathleen L.
   McNulty, Amy
   Malsiner, Caye
   Dragu, Adrian
   Horch, Raymund E.
TI Changes of anabolic processes at the cellular and molecular level in
   chronic wounds under topical negative pressure can be revealed by
   transcriptome analysis
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE topical negative pressure; reticulated open cell foam; vacuum assisted
   closure therapy; microarray; quantitative real time PCR; transcriptome
   analysis
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; TISSUE; THERAPY; MANAGEMENT;
   ULCERS; TRANSPLANTATION; PROLIFERATION; FIBROBLASTS; MEDICINE
AB Chronic wounds - as defined by the World Union of Wound Healing Societies (WUWHS) - are a considerable worldwide health care expense and impair quality of life. In order for chronic wounds to heal, these wounds must be transformed to a more acute state to begin the healing process. Topical negative pressure (TNP) with reticulated open cell foam (ROCF) is known to promote healing in certain types of chronic wounds. However, little is known about changes at the cellular or molecular level in wounds under various treatments, especially under the physical forces induced to tissue by TNP. In the current study, chronic wound samples were obtained during routine wound debridements prior to treatment and 7-12 days after initiating TNP with a continuous setting at -125 mmHg. Whole genome transcriptome microarray analyses were performed on samples to better understand how TNP with ROCF affects these types of wounds. It was found that more genes were expressed following TNP with ROCF as compared to before therapy and to normal, non-wounded tissue. In this study, we show that TNP with ROCF transforms the chronic wound from its inflammation (non-healing) state into more of a progressive, healing phenotype from a molecular point of view with expression of genes that are commonly associated with these terms.
C1 [Leffler, Mareike; Malsiner, Caye; Dragu, Adrian; Horch, Raymund E.] Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
   [Derrick, Kathleen L.; McNulty, Amy] Kinet Concepts Inc, San Antonio, TX USA.
C3 University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Univ Hosp, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@uk-erlangen.de
RI Dragu, Adrian/AAH-3506-2019; Horch, Raymund E/H-8128-2019
OI Dragu, Adrian/0000-0003-4633-2695; Horch, Raymund E/0000-0002-6561-2353
FU Kinetic Concepts Inc. [VACP 2005-17]; Erlangen University [Fe 34499008]
FX Preliminary data of this study have been presented at the
   Drei-Lander-Kongress on VAC Therapy in Zurich, 16 April 2010 and have
   been printed in the supplementary abstract issue of the Zeitschrift fur
   Wundheilung. This study was supported by a research grant of Kinetic
   Concepts Inc. to the Friedrich-Alexander-University of
   Erlangen-Nuernberg (Grant Nr. VACP 2005-17; Erlangen University Nr. Fe
   34499008). The study was approved by the Ethical committee
   Friedrich-Alexander-University of Erlangen-Nuernberg clearance: Nr.
   3343. We thank PD Dr. med. Ulrich Kneser for operating the clinical
   cases presented in Figures 1 and 2.
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   Brem H, 2007, MOL MED, V13, P30, DOI 10.2119/2006-00054.Brem
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NR 49
TC 13
Z9 15
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JUL
PY 2011
VL 15
IS 7
BP 1564
EP 1571
DI 10.1111/j.1582-4934.2010.01147.x
PG 8
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA 783RI
UT WOS:000292101300012
PM 20716124
OA Bronze
DA 2026-07-24
ER
PT J
AU Peinemann, F
   Sauerland, S
AF Peinemann, Frank
   Sauerland, Stefan
TI Negative-Pressure Wound Therapy Systematic Review of Randomized
   Controlled Trials
SO DEUTSCHES ARZTEBLATT INTERNATIONAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; MANAGEMENT; ULCERS
AB Background: In negative-pressure wound therapy (NPWT), a wound is covered with an airtight dressing, and negative pressure is applied. This is thought to promote healing. We evaluated NPWT with an updated, systematic review of the literature.
   Methods: We systematically searched the PubMed and Cochrane Library databases for randomized, controlled trials (RCTs) of NPWT for the treatment of acute or chronic wounds. The primary outcome was complete wound closure.
   Results: We found reports of 9 RCTs in addition to the 12 covered by earlier IQWiG reviews of this topic. Five of the 9 new trials involved NPWT systems that are not on the market. The frequency of complete wound closure is stated in only 5 of the 9 new reports; a statistically significant effect in favor of NPWT was found in only two trials. The results of 8 of the 9 new trials are hard to interpret, both because of apparent bias and because diverse types of wounds were treated.
   Conclusion: Although there may be a positive effect of NPWT, we did not find clear evidence that wounds heal any better or worse with NPWT than with conventional treatment. Good RCTs are still needed to evaluate NPWT.
C1 [Peinemann, Frank; Sauerland, Stefan] IQWIG, D-51105 Cologne, Germany.
RP Peinemann, F (通讯作者)，IQWIG, Dillenburger Str 27, D-51105 Cologne, Germany.
EM frank.peinemann@iqwig.de
RI ; /H-2800-2019
OI Sauerland, Stefan/0000-0003-1048-796X; 
FU Institute for Quality and Efficiency in Health Care (Institut fur
   Qualitat und Wirtschaftlichkeit im Gesundheitswesen, IQWiG)
FX This article was sponsored by the Institute for Quality and Efficiency
   in Health Care (Institut fur Qualitat und Wirtschaftlichkeit im
   Gesundheitswesen, IQWiG).
CR [Anonymous], N0403 IQWIG
   [Anonymous], SER COMPL ASS NEG PR
   [Anonymous], DRAFT GUID IND CHRON
   [Anonymous], N0602 IQWIG
   [Anonymous], STUD VAK BEL CHRON W
   [Anonymous], VERG STUD VAK RAP
   [Anonymous], NEG PRESS WOUND THER
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 35
TC 94
Z9 110
U1 0
U2 15
PU DEUTSCHER AERZTE-VERLAG GMBH
PI COLOGNE
PA DIESELSTRABE 2, POSTFACH 400265, D-50859 COLOGNE, GERMANY
SN 1866-0452
J9 DTSCH ARZTEBL INT
JI Dtsch. Arztebl. Int.
PD JUN 3
PY 2011
VL 108
IS 22
BP 381
EP U15
DI 10.3238/arztebl.2011.0381
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 787OR
UT WOS:000292387100001
PM 21712971
DA 2026-07-24
ER
PT J
AU Stechl, NM
   Baumeister, S
   Grimm, K
   Kraus, TW
   Bockhorn, H
   Exner, KE
AF Stechl, N. M.
   Baumeister, S.
   Grimm, K.
   Kraus, T. W.
   Bockhorn, H.
   Exner, K. E.
TI Microsurgical reconstruction of the pelvic floor after pelvic
   exenteration
SO CHIRURG
LA German
DT Article
DE Rectal cancer; Pelvic exenteration; Microvascular tissue transfer;
   Latissimus dorsi muscle flaps; Postoncological reconstruction
ID RECTAL-CANCER; COLORECTAL-CARCINOMA; RESECTION; RECURRENCE; SURGERY;
   WOUNDS
AB Pelvic exenteration for advanced or recurrent rectal cancer often results in complex defects associated with high complication rates and morbidity for the patients. The goal of therapy is therefore restoration of functional stability and adequate soft tissue coverage, thus enhancing the quality of life with limited life expectancy by an interdisciplinary approach.
   We report on eight patients treated by combined interdisciplinary pelvic exenteration with resection of the sacrum and subsequent coverage of the pelvic floor defect with free latissimus dorsi muscle flaps. All patients were treated in two stages according to a pre-established therapeutic algorithm. First, an abdominal and transsacral pelvic exenenteration was performed with an ileostomy and ileum conduit system and the pelvic floor was closed with vicryl meshes. The open wound was optimized by vacuum-assisted closure (VAC) therapy before reconstruction of the pelvic floor was undertaken 10-12 days later with free latissimus dorsi musculocutaneous flaps either anastomosed to the lower or upper gluteal vessels or to an AV-loop using the saphenous vein as connection to the groin vessels.
   In all cases a sufficient and stable reconstruction of the pelvic floor could be achieved and no flap loss occurred. In three patients a minor wound dehiscence occurred, which could be closed by secondary suture. The time span between the free flap transfer and stable wound closure was 19-28 days. Later complications such as fistula formation and chronic wound infections were not observed. The survival of the patients ranged from 10-36 months.
   The present two-stage concept of pelvic floor reconstruction with free latissimus dorsi muscle flaps for wound closure after pelvic exenteration improves postoperative morbidity and mortality and increases the quality of life of the affected patients. A shortened period of open wound therapy brings additional economic benefits. Because of its anatomical features the free latissimus dorsi flap can be regarded as the method of choice of microsurgical reconstruction within an interdisciplinary concept after pelvic exenteration.
C1 [Stechl, N. M.; Baumeister, S.; Exner, K. E.] Markus Krankenhaus, Klin Plast Wiederherstellungs & Handchirurg, D-60431 Frankfurt, Germany.
   [Grimm, K.; Kraus, T. W.; Bockhorn, H.] Krankenhaus NW Frankfurt, Klin Allgemein & Visceralchirurg, Frankfurt, Germany.
C3 Krankenhaus Nordwest
RP Stechl, NM (通讯作者)，Markus Krankenhaus, Klin Plast Wiederherstellungs & Handchirurg, Wilhelm Epstein Str 4, D-60431 Frankfurt, Germany.
EM N.Stechl@gmx.de
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NR 22
TC 5
Z9 6
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-4722
J9 CHIRURG
JI Chirurg
PD JUL
PY 2011
VL 82
IS 7
BP 625
EP 630
DI 10.1007/s00104-010-2022-3
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 789JM
UT WOS:000292511800010
PM 21161142
DA 2026-07-24
ER
PT J
AU Liu, J
   Morykwas, MJ
   Argenta, LC
   Wagner, WD
AF Liu, Jie
   Morykwas, Michael J.
   Argenta, Louis C.
   Wagner, William D.
TI Development of a biodegradable foam for use in negative pressure wound
   therapy
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE negative pressure wound therapy; poly(epsilon-caprolactone); foam; foam
   dressing; biodegradable polymer
ID VACUUM-ASSISTED CLOSURE; IN-VITRO; DEGRADATION; SCAFFOLDS
AB Treatment of wounds using negative pressure wound therapy (NPWT) uses a nondegradable polyvinyl alcohol (PVA) foam in the application of negative pressures typically for 1-3 days. The purpose of this study was to construct and test biodegradable poly(e-caprolactone) (PCL) foam as a substitute for the PVA foam. Such a foam would be left within the wound until healing was achieved and form a biodegradable matrix into which tissue would grow. The use of such foam would obviate the need for any serial foam changes and a final foam removal, thus making patient care much easier and more economical. PCL foams were prepared by salt leaching and phase separation. Morphological and mechanical properties of the foams were characterized and compared to PVA foam. PCL and PVA foams were tested on the uncut surface of a pig liver maintained in a hydration chamber continuously replenished with saline under the conditions of negative pressure of 50 mm Hg for 72 h. The results demonstrated that PCL foam made from phase separation had the similar properties and function as the PVA foam. The results demonstrate that PCL foam is an appropriate substitute for currently used nondegradable PVA foam in NPWT applications. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 98B: 316-322, 2011.
C1 [Liu, Jie; Morykwas, Michael J.; Argenta, Louis C.; Wagner, William D.] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Wound Repair Nanomed Res Program, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Wagner, WD (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Wound Repair Nanomed Res Program, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM wwagner@wfubmc.edu
OI Morykwas, Michael/0009-0001-5547-5172
CR Aparna S., 2005, BIOMATERIALS, V26, P5500
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Banwell Paul, 2006, J Tissue Viability, V16, P16
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   de Lange MY, 2000, EUR J PLAST SURG, V23, P178, DOI 10.1007/s002380050244
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
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   Lam CXF, 2009, J BIOMED MATER RES A, V90A, P906, DOI 10.1002/jbm.a.32052
   Mikos A.G., 2000, Electronic Journal of Biotechnology, V3, P114
   Miller MS, 2005, OSTOMY WOUND MANAG, V51, P44
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Peña J, 2006, J BIOMED MATER RES A, V76A, P788, DOI 10.1002/jbm.a.30547
   Sanger C, 2007, J CRANIOFAC SURG, V18, P926, DOI 10.1097/scs.0b013e3180a771e9
   Timmers MS, 2009, WOUND REPAIR REGEN, V17, P278, DOI 10.1111/j.1524-475X.2009.00458.x
   Vaz CM, 2005, ACTA BIOMATER, V1, P575, DOI 10.1016/j.actbio.2005.06.006
   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
   Wu LB, 2004, BIOMATERIALS, V25, P5821, DOI 10.1016/j.biomaterials.2004.01.038
NR 24
TC 12
Z9 13
U1 0
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD AUG
PY 2011
VL 98B
IS 2
BP 316
EP 322
DI 10.1002/jbm.b.31854
PG 7
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 789NN
UT WOS:000292522300015
PM 21648059
DA 2026-07-24
ER
PT J
AU Stinner, DJ
   Waterman, SM
   Masini, BD
   Wenke, JC
AF Stinner, Daniel J.
   Waterman, Scott M.
   Masini, Brendan D.
   Wenke, Joseph C.
TI Silver Dressings Augment the Ability of Negative Pressure Wound Therapy
   to Reduce Bacteria in a Contaminated Open Fracture Model
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article; Proceedings Paper
CT 52nd Annual Meeting of the Society-of-Military-Orthopedic-Surgeons
   (SOMOS)
CY DEC 14-17, 2010
CL Vail, CO
SP Soc Mil Orthoped Surg
DE Contamination; Infection; Open fracture; Negative pressure; Silver
   dressing
ID VACUUM-ASSISTED CLOSURE
AB Background: Despite a lack of evidence supporting their use, silver dressings are often used with negative pressure wound therapy (NPWT). This study investigates the effectiveness of silver dressings to reduce bacteria in contaminated wounds when used with NPWT.
   Methods: Complex orthopedic wounds were created on the proximal left legs of anesthetized goats. The wounds were inoculated with either a strain of bioluminescent Pseudomonas aeruginosa or Staphylococcus aureus. These bacteria are genetically modified to emit photons, thereby allowing quantification of bacterial concentration with a photon-counting camera system. The wounds were debrided 6 hours after inoculation and were treated with silver impregnated gauze combined with NPWT. Repeat debridements were performed every 48 hours for 6 days. Imaging was performed pre- and postdebridement. These results were compared with standard NPWT controls that used dressings without silver.
   Results: There were fewer bacteria in the silver groups than the standard NPWT groups at 6 days. In the groups that were inoculated with P. aeruginosa, wounds in the silver group contained 21% +/- 5% of baseline bacterial load compared with 43% +/- 14% in the standard NPWT group. The addition of the silver dressings has a more pronounced effect on Staphylococcus. Wounds in the silver group contained 25% +/- 8% of baseline bacterial load compared with 115% +/- 19% in the standard NPWT group.
   Conclusions: The use of silver dressings with NPWT is a fairly common practice with limited literature to support its use in contaminated wounds. This study demonstrates that the addition of a silver dressing to NPWT effectively reduces bacteria in contaminated wounds and is more beneficial on the gram-positive bacteria. These data support the use of silver dressings in contaminated wounds, particularly ones contaminated by S. aureus.
C1 [Stinner, Daniel J.; Waterman, Scott M.; Masini, Brendan D.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Wenke, JC (通讯作者)，USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
EM joseph.wenke@us.army.mil
RI Stinner, Daniel/KSM-9513-2024
OI Stinner, Daniel/0000-0002-8981-6262
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bluman EM, 2009, FOOT ANKLE INT, V30, P62, DOI 10.3113/FAI.2009.0062
   Castellano Joseph J, 2007, Int Wound J, V4, P114, DOI 10.1111/j.1742-481X.2007.00316.x
   Gerry R, 2007, ANN PLAS SURG, V59, P58, DOI 10.1097/01.sap.0000263420.70303.cc
   Gravante G, 2009, ANN PLAS SURG, V63, P201, DOI 10.1097/SAP.0b013e3181893825
   GUSTILO RB, 1976, J BONE JOINT SURG AM, V58, P453, DOI 10.2106/00004623-197658040-00004
   Keeling JJ, 2008, J BONE JOINT SURG AM, V90A, P2643, DOI 10.2106/JBJS.G.01326
   Lalliss SJ, 2010, J ORTHOP TRAUMA, V24, P598, DOI 10.1097/BOT.0b013e3181ec45ba
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Murray CK, 2008, J TRAUMA, V64, pS232, DOI 10.1097/TA.0b013e318163c3f5
   Nanchahal J, 2009, STANDARDS MANAGEMENT, P26
   Payne JL, 2009, J BIOMED MATER RES B, V89B, P217, DOI 10.1002/jbm.b.31209
   SCHADE VL, 2010, PODIATRY TODAY  0901
   Schlatterer D, 2008, J ORTHOP TRAUMA, V22, pS152, DOI 10.1097/BOT.0b013e318188e2d7
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 18
TC 44
Z9 54
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD JUL
PY 2011
VL 71
SU 1
BP S147
EP S150
DI 10.1097/TA.0b013e318221944a
PG 4
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Surgery
GA 790RW
UT WOS:000292607900025
PM 21795872
DA 2026-07-24
ER
PT J
AU Farrell, D
   Murphy, S
AF Farrell, Dawn
   Murphy, Siobhan
TI Negative Pressure Wound Therapy for Recurrent Pilonidal Disease A Review
   of the Literature
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; SINUS; FLAP; CARCINOMA;
   SURGERY
AB Pilonidal disease arises from hair follicles of the gluteal cleft and may result in a chronic exudative disorder. The management of pilonidal disease following surgical excision remains controversial, despite an abundance of research into different treatment options. Negative pressure wound therapy is an emerging treatment option for complex or recurrent pilonidal disease. We performed a comprehensive literature search, using the electronic databases MEDLINE, Cochrane library, CINAHL, PubMed, and Web of Knowledge. All studies, case reports, and multiple case series evaluating the use of negative pressure wound therapy for treatment of pilonidal disease were included. Despite the breadth of our search parameters, we identified limited studies addressing this issue; all were published between 2003 and 2007. Findings of 5 case reports or multiple case series tentatively suggest that negative pressure wound therapy may be an emerging treatment option for pilonidal disease management. However, we recommend that more rigorous research, including randomized controlled trials, be conducted before implications can be drawn for evidence-based practice.
C1 [Farrell, Dawn; Murphy, Siobhan] Univ Coll Cork, Catherine McAuley Sch Nursing & Midwifery, Cork, Ireland.
C3 University College Cork
RP Farrell, D (通讯作者)，Univ Coll Cork, Catherine McAuley Sch Nursing & Midwifery, Cork, Ireland.
EM d.farrell@ucc.ie
OI Murphy, Siobhan/0000-0003-1795-2887
CR AJAZ S, 2007, GASTROINTEST NURS, V5, P20
   Akin M, 2008, COLORECTAL DIS, V10, P945, DOI 10.1111/j.1463-1318.2008.01563.x
   Banwell P E, 2003, J Wound Care, V12, P22
   Bendewald FR, 2007, OSTOMY WOUND MANAG, V53, P40
   Bethell E, 2003, J Wound Care, V12, P237
   Cooper SM, 2000, INT J DERMATOL, V39, P896, DOI 10.1046/j.1365-4362.2000.00157-3.x
   de Bree E, 2001, ANN SURG ONCOL, V8, P60, DOI 10.1245/aso.2001.8.1.60
   Duxbury M S, 2003, J Wound Care, V12, P355
   Dylek ON, 1998, EUR J SURG, V164, P961
   *EUR WOUND MAN ASS, 2008, POS DOC NEG PRESS WO
   *EUR WOUND MAN ASS, 2008, POS DOC HAND TO HEAL
   Hamilton C, 2008, J Wound Care, V17, P359
   Jones A M, 2006, J Wound Care, V15, P65
   JOSEPH J, 2002, WOUNDS COMPENDIUM CL, V12, P60
   Kaufman Melissa W, 2003, Dermatol Nurs, V15, P317
   Kulacoglu H, 2008, COLORECTAL DIS, V10, P949, DOI 10.1111/j.1463-1318.2007.01463.x
   Lynch JB, 2004, DIS COLON RECTUM, V47, P929, DOI 10.1007/s10350-004-0522-2
   Marsh Ann, 2008, Nurs Stand, V22, P59
   McCallum IJD, 2008, BMJ-BRIT MED J, V336, P868, DOI 10.1136/bmj.39517.808160.BE
   *MCGILL U HLTH CTR, 19 MCGILL U HLTH CTR
   McGuinness JG, 2003, DIS COLON RECTUM, V46, P274, DOI 10.1007/s10350-004-6535-z
   Miller D, 2003, WORLD WIDE WOUNDS
   Mouës CM, 2007, J PLAST RECONSTR AES, V60, P672, DOI 10.1016/j.bjps.2006.01.041
   Moues C M, 2005, J Wound Care, V14, P224
   O'Flynn L, 2000, J Wound Care, V9, P337
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   Stewart A, 2008, J Wound Care, V17, P468
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   Ubbink DT, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001898.pub2
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   Williamson JD, 1999, DIAGN CYTOPATHOL, V20, P367, DOI 10.1002/(SICI)1097-0339(199906)20:6<367::AID-DC7>3.0.CO;2-S
NR 36
TC 20
Z9 27
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2011
VL 38
IS 4
BP 373
EP 378
DI 10.1097/WON.0b013e31821e5117
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 791BC
UT WOS:000292633800009
PM 21606863
DA 2026-07-24
ER
PT J
AU Pour, SM
AF Pour, Saman Mohammadi
TI Use of Negative Pressure Wound Therapy With Silver Base Dressing for
   Necrotizing Fasciitis
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
AB BACKGROUND: Necrotizing fasciitis is a life-threatening infection requiring urgent surgical and medical therapy. Hemodynamic stabilization and antimicrobial therapy precede aggressive surgical excision of necrotic tissue, which should be performed as soon as possible. The rapidly spreading infection and aggressive surgical intervention create challenges for wound management. Multiple dressings are available to address the various challenges associated with management of these wounds; this article discusses negative pressure therapy and antimicrobial dressings in the management of Fournier's gangrene, a form of necrotizing fasciitis that involves tissue of the genital or perianal areas.
   CASE PRESENTATION: This article reviews the case of a 56-year-old man with fever, tachycardia, and perianal pain associated with necrotizing fasciitis. Extensive surgical debridement was done on the day of admission. After several irrigations, the wound was dressed by negative pressure wound therapy with a silver dressing that minimized hospital stay and enabled early reconstruction.
   CONCLUSION: We found that negative pressure wound therapy with a silver-based dressing promoted wound healing and provided a solid matrix for surgical reconstruction.
C1 Univ Tehran Med Sci, Hazrat Rasool Hosp, Dept Gen Surg, Tehran, Iran.
C3 Tehran University of Medical Sciences
RP Pour, SM (通讯作者)，Univ Tehran Med Sci, Hazrat Rasool Hosp, Dept Gen Surg, Niayesh Ave, Tehran, Iran.
EM samanmp@yahoo.com
RI mohammadipour, saman/AAN-5852-2021
OI mohammadipour, saman/0000-0002-9178-6701
CR BARANOSKI S, 2008, WOUND CARE ESSENTIAL, P151
   Campbell PE, 2006, J WOUND OSTOMY CONT, V33, P176, DOI 10.1097/00152192-200603000-00014
   DWYER S, SILVER IS PRECIOUS W
   Miller LG, 2005, NEW ENGL J MED, V352, P1445, DOI 10.1056/NEJMoa042683
   Park H, 2010, SURG CLIN N AM, V90, P1181, DOI 10.1016/j.suc.2010.08.001
   Thwaini A, 2006, POSTGRAD MED J, V82, P516, DOI 10.1136/pgmj.2005.042069
NR 6
TC 13
Z9 19
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2011
VL 38
IS 4
BP 449
EP 452
DI 10.1097/WON.0b013e31821e43f1
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 791BC
UT WOS:000292633800018
PM 21747263
DA 2026-07-24
ER
PT J
AU Anesäter, E
   Borgquist, O
   Hedström, E
   Waga, J
   Ingemansson, R
   Malmsjö, M
AF Anesater, Erik
   Borgquist, Ola
   Hedstrom, Erik
   Waga, Julia
   Ingemansson, Richard
   Malmsjo, Malin
TI The influence of different sizes and types of wound fillers on wound
   contraction and tissue pressure during negative pressure wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Experimental surgery; Negative pressure wound therapy; Tissue pressure;
   Wound contraction; Wound healing
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; BLOOD-FLOW; GAUZE;
   FOAM
AB Negative pressure wound therapy (NPWT) contracts the wound and alters the pressure in the tissue of the wound edge, which accelerates wound healing. The aim of this study was to examine the effect of the type (foam or gauze) and size (small or large) of wound filler for NPWT on wound contraction and tissue pressure. Negative pressures between -20 and -160 mmHg were applied to a peripheral porcine wound (n = 8). The pressure in the wound edge tissue was measured at distances of 0.1, 0.5, 1.0 and 2.0 cm from the wound edge and the wound diameter was determined. At 0.1 cm from the wound edge, the tissue pressure decreased when NPWT was applied, whereas at 0.5 cm it increased. Tissue pressure was not affected at 1.0 or 2.0 cm from the wound edge. The tissue pressure, at 0.5 cm from the wound edge, was greater when using a small foam than when using than a large foam. Wound contraction was greater when using a small foam than when using a large foam during NPWT. Gauze resulted in an intermediate wound contraction that was not affected by the size of the gauze filler. The use of a small foam to fill the wound causes considerable wound contraction and may thus be used when maximal mechanical stress and granulation tissue formation are desirable. Gauze or large amounts of foam result in less wound contraction which may be beneficial, for example when NPWT causes pain to the patient.
C1 [Anesater, Erik; Borgquist, Ola; Waga, Julia; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Anesater, Erik; Borgquist, Ola; Hedstrom, Erik; Waga, Julia; Ingemansson, Richard; Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
   [Borgquist, Ola] Lund Univ, Dept Anesthesiol & Intens Care, Lund, Sweden.
   [Hedstrom, Erik] Lund Univ, Dept Clin Physiol, Lund, Sweden.
   [Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University; Lund University
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Borgquist, Ola/AAO-6451-2020
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599; Hedström, Erik/0000-0003-0041-9357; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P E, 2003, J Wound Care, V12, P22
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
   Borgquist O, 2010, OSTOMY WOUND MANAG, V56, P60
   Borgquist O, 2010, PLAST RECONSTR SURG, V125, P502, DOI 10.1097/PRS.0b013e3181c82e1f
   Borgquist O, 2009, WOUNDS, V21, P302
   Kairinos N, 2010, J PLAST RECONSTR AES, V63, P174, DOI 10.1016/j.bjps.2008.08.037
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
   Krasner Diane L, 2002, Ostomy Wound Manage, V48, P38
   MALMSJO M, 2010, WOUNDS INT, V1
   Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   Malmsjö M, 2011, INTERACT CARDIOV TH, V12, P349, DOI 10.1510/icvts.2010.249078
   Malmsjö M, 2009, WOUND REPAIR REGEN, V17, P200, DOI 10.1111/j.1524-475X.2009.00461.x
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Murphey GC, 2009, WOUND REPAIR REGEN, V17, P113, DOI 10.1111/j.1524-475X.2008.00448.x
   Petzina R, 2006, EUR J CARDIO-THORAC, V30, P85, DOI 10.1016/j.ejcts.2006.04.009
   Sisco M, 2009, PLAST RECONSTR SURG, V123, P599, DOI 10.1097/PRS.0b013e318196ba00
   Sjögren J, 2003, ANN THORAC SURG, V75, P1311, DOI 10.1016/S0003-4975(02)04570-8
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
   Willy C, 2004, ZBL CHIR, V129, pS6
NR 22
TC 27
Z9 31
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2011
VL 8
IS 4
BP 336
EP 342
DI 10.1111/j.1742-481X.2011.00790.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 791HB
UT WOS:000292654600004
PM 21564550
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Fraccalvieri, M
   Zingarelli, E
   Ruka, E
   Antoniotti, U
   Coda, R
   Sarno, A
   Bocchiotti, MA
   Bruschi, S
AF Fraccalvieri, Marco
   Zingarelli, Enrico
   Ruka, Erind
   Antoniotti, Umberto
   Coda, Renato
   Sarno, Antonino
   Bocchiotti, Maria Alessandra
   Bruschi, Stefano
TI Negative pressure wound therapy using gauze and foam: histological,
   immunohistochemical and ultrasonography morphological analysis of the
   granulation tissue and scar tissue. Preliminary report of a clinical
   study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chariker-Jeter method; Foam; Gauze; Negative pressure wound therapy; VAC
   therapy
ID VACUUM-ASSISTED CLOSURE; STATE
AB Negative pressure wound therapy (NPWT) is becoming routine for the preparation of wounds prior to grafting for wound closure. We have been using both foam- and gauze-based NPWT to prepare wounds for closure prior to skin grafting and have obtained similar proportions of closed wounds; 7/7 for wounds treated with gauze-based NPWT and 11/11 for wounds treated with foam-based NPWT. In our follow-up consultations we observed that skin grafts on the foam-treated patients were less pliable than those on the gauze-treated patients. To assess what the mechanism of this effect might be, we compared the specific details of the treatments of both 11 foam and 7 gauze patients, including depth, location, patients' age and co-morbidity; biopsies of granulation and scar tissue were taken and stained with haematoxylin-eosin and by Masson's trichrome staining and conducted ultrasound analysis of the closed wounds, to see if there were features which explained those effects. All foam patients were treated at -125 mm Hg for an average of 25.9 days before skin grafts were applied. All gauze patients were treated at -80 mm Hg for an average of 24.7 days before skin grafts were applied. Biopsies of granulation tissue prior to skin grafting from five foam and four gauze-based NPWT patients did not reveal any obvious histological differences between the treatments. Ultrasound analysis of the skin-grafted wounds showed an average depth of scar tissue of 18 mm in the wound beds of the foam-treated wounds and 7 mm in the gauze-treated ones. Biopsies taken on the scar tissue after treatment with the gauze showed a minor tissue thickness and disorganisation and less sclerotic components. The findings of this preliminary analysis suggest that foam-based NPWT may induce a thicker layer of scar tissue beneath skin grafts than gauze-based NPWT which might explain a reduced pliability of the reconstructed bed. At present it is unclear which mechanism might be responsible for the difference in pressure (-125 versus -80 mm Hg), either the length of the time taken to reconstruct the wound bed or the intrinsic nature of the foam or gauze on the tissue surface. Prospective studies are necessary to investigate whether these preliminary observations are confirmed and to investigate what the mechanism might be.
C1 [Fraccalvieri, Marco; Zingarelli, Enrico; Ruka, Erind; Antoniotti, Umberto; Bocchiotti, Maria Alessandra; Bruschi, Stefano] Univ Turin, San Giovanni Battista Hosp, Dept Reconstruct & Aesthet Plast Surg, Turin, Italy.
   [Coda, Renato] Gradenigo Hosp, Dept Pathol Anat, Turin, Italy.
   [Sarno, Antonino] San Giovanni Battista Hosp, Dept Radiodiagnost, Turin, Italy.
C3 University of Turin; A.O.U. Citta della Salute e della Scienza di
   Torino; AOU San Giovanni Battista-Molinette; Humanitas Hospital
   Gradenigo; A.O.U. Citta della Salute e della Scienza di Torino; AOU San
   Giovanni Battista-Molinette
RP Fraccalvieri, M (通讯作者)，Univ Turin, San Giovanni Battista Hosp, Dept Reconstruct & Aesthet Plast Surg, Turin, Italy.
EM marco@fraccalvieri.it
RI ; /AAF-4387-2019
OI Bruschi, Stefano/0000-0002-4746-9864; Bocchiotti, Maria
   Alessana/0000-0003-0723-1074; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Borgquist O, 2009, WOUNDS, V21, P302
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   Sisco M, 2009, PLAST RECONSTR SURG, V123, P599, DOI 10.1097/PRS.0b013e318196ba00
   *SMITH NEPH, VISTA REC US PROT
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NR 25
TC 23
Z9 32
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2011
VL 8
IS 4
BP 355
EP 364
DI 10.1111/j.1742-481X.2011.00798.x
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 791HB
UT WOS:000292654600006
PM 21564551
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Ingemansson, R
   Malmsjo, M
AF Lindstedt, Sandra
   Ingemansson, Richard
   Malmsjo, Malin
TI Haemodynamic effects of negative pressure wound therapy when using a
   rigid barrier to prevent heart rupture
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Animal model; Experimental surgery; Haemodynamics; Negative pressure
   wound therapy; Sternotomy wound
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   INFECTION; EXPERIENCE; ALGORITHM
AB Right ventricular heart rupture is a devastating complication associated with negative pressure wound therapy (NPWT) in cardiac surgery. The use of a rigid barrier has been suggested to offer protection against this lethal complication by preventing the heart from being drawn up and damaged by the sharp sternum bone edges. The aim of this study was to investigate the haemodynamic effects of placing a rigid barrier over the heart to protect it from rupture during NPWT. Eight pigs underwent median sternotomy followed by NPWT at -70 and -120 mmHg, using foam, with or without a rigid plastic disc between the heart and the sternal edges. The heart frequency, cardiac output, mean systemic arterial pressure, mean pulmonary artery pressure, central venous pressure and left atrial pressure were recorded. Cardiac output was not affected by NPWT, regardless of whether a rigid barrier was used. Heart frequency decreased during NPWT without a disc, and showed a tendency towards a decrease when using a rigid disc. The blood pressure decreased during NPWT without a disc, and showed only a tendency towards a decrease when a disc was inserted between the heart and the sternum. In conclusion, the results of this haemodynamic study show that a rigid disc can safely be placed over the heart during NPWT, to prevent heart rupture. The haemodynamic effects of NPWT in sternotomy wounds are slightly reduced by the presence of the rigid disc.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   [Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473;
   Ingemansson, Richard/0000-0001-7623-8953
CR Conquest AM, 2003, J SURG RES, V115, P209, DOI 10.1016/S0022-4804(03)00331-7
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Ennker IC, 2009, J CARDIOTHORAC SURG, V4, DOI 10.1186/1749-8090-4-5
   Fleck Tatjana, 2006, Int Wound J, V3, P273, DOI 10.1111/j.1742-481X.2006.00273.x
   Gustafsson R, 2006, PLAST RECONSTR SURG, V117, P1167, DOI 10.1097/01.prs.0000200620.77353.40
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Khoynezhad A, 2004, J CARDIAC SURG, V19, P74, DOI 10.1111/j.0886-0440.2004.04015.x
   Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   Malmsjö M, 2009, J THORAC CARDIOV SUR, V138, P712, DOI 10.1016/j.jtcvs.2008.11.068
   Mokhtari A, 2009, INT WOUND J, V6, P48, DOI 10.1111/j.1742-481X.2008.00566.x
   Petzina R, 2007, J THORAC CARDIOV SUR, V133, P1154, DOI 10.1016/j.jtcvs.2007.01.011
   Poncelet AJ, 2008, EUR J CARDIO-THORAC, V33, P232, DOI 10.1016/j.ejcts.2007.11.016
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   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Sjogren Johan, 2004, Interact Cardiovasc Thorac Surg, V3, P666, DOI 10.1016/j.icvts.2004.08.003
   Steigelman MB, 2009, ANN THORAC SURG, V88, P1277, DOI 10.1016/j.athoracsur.2009.06.027
NR 22
TC 5
Z9 5
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2011
VL 8
IS 4
BP 385
EP 392
DI 10.1111/j.1742-481X.2011.00803.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 791HB
UT WOS:000292654600009
PM 21585658
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Anesäter, E
   Roupé, M
   Robertsson, P
   Borgquist, O
   Torbrand, C
   Ingemansson, R
   Lindstedt, S
   Malmsjö, M
AF Anesater, Erik
   Roupe, Markus
   Robertsson, Peter
   Borgquist, Ola
   Torbrand, Christian
   Ingemansson, Richard
   Lindstedt, Sandra
   Malmsjo, Malin
TI The influence on wound contraction and fluid evacuation of a rigid disc
   inserted to protect exposed organs during negative pressure wound
   therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Fluid removal; Negative pressure wound therapy; Protective disc; Wound
   contraction; Wound healing
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS;
   METALLOPROTEINASES; EXPERIENCE; MARKERS; ULCERS
AB The use of a rigid disc as a barrier between the wound bed and the wound filler during negative pressure wound therapy (NPWT) has been suggested to prevent damage to exposed organs. However, it is important to determine that the effects of NPWT, such as wound contraction and fluid removal, are maintained during treatment despite the use of a barrier. This study was performed to examine the effect of NPWT on wound contraction and fluid evacuation in the presence of a rigid disc. Peripheral wounds were created on the backs of eight pigs. The wounds were filled with foam, and rigid discs of different designs were inserted between the wound bed and the foam. Wound contraction and fluid evacuation were measured after application of continuous NPWT at -80 mmHg. Wound contraction was similar in the presence and the absence of a rigid disc (84 +/- 4% and 83 +/- 3%, respectively, compared with baseline). Furthermore, the rigid disc did not affect wound fluid removal compared with ordinary NPWT (e.g. after 120 seconds, 71 +/- 4 ml was removed in the presence and 73 +/- 3 ml was removed in the absence of a disc). This study shows that a rigid barrier may be placed under the wound filler to protect exposed structures during NPWT without affecting wound contraction and fluid removal, which are two crucial features of NPWT.
C1 [Anesater, Erik; Roupe, Markus; Robertsson, Peter; Borgquist, Ola; Torbrand, Christian; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Anesater, Erik; Borgquist, Ola; Torbrand, Christian; Ingemansson, Richard; Lindstedt, Sandra; Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
   [Borgquist, Ola] Lund Univ, Dept Anesthesiol & Intens Care, Lund, Sweden.
   [Torbrand, Christian; Ingemansson, Richard; Lindstedt, Sandra] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Torbrand, Christian/HIZ-8092-2022; Roupé, Markus/K-6502-2014; Borgquist,
   Ola/AAO-6451-2020; Lindstedt, Sandra/AEM-2892-2022
OI Torbrand, Christian/0000-0001-6442-7554; Ingemansson,
   Richard/0000-0001-7623-8953; Roupé, Markus/0000-0001-5472-8134; Maljö,
   Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473
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   BLAKELY M, SAWC 2007
   BORGQUIST O, PLAST RECON IN PRESS
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NR 36
TC 9
Z9 10
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2011
VL 8
IS 4
BP 393
EP 399
DI 10.1111/j.1742-481X.2011.00805.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 791HB
UT WOS:000292654600010
PM 21585660
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Lee, DL
   Ryu, AY
   Rhee, SC
AF Lee, Dong Lark
   Ryu, An Young
   Rhee, Seung Chul
TI Negative pressure wound therapy: an adjuvant to surgical reconstruction
   of large or difficult skin and soft tissue defects
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; NPWT; Skin defect; Skin graft; VAC
ID VACUUM-ASSISTED CLOSURE; DEVICE; GRAFTS
AB Wide and deep wound defects are a challenge to surgeons, particularly when aggressive or more radical operations are unavailable. This article introduces refined techniques, indications and the clinical experience of the application of negative pressure wound therapy (NPWT) as an easy ancillary wound dressing method for the reconstruction of large or difficult skin and soft tissue defects. The authors used NPWT on 88 patients as an adjuvant therapy before reconstructive surgery since 2006. NPWT was applied for two different treatment strategies: as an adjuvant therapy to facilitate the formation of a healthy wound bed and to reduce the size and depth of a defect. NPWT was used as an alternative dressing method for skin grafting for infants or mobile skin surfaces such as the neck, penis, dorsum of the hand, knee joint, abdomen, etc. There were no typical wound complications. NPWT application, if used appropriately, produces successful surgical reconstructions for large, deep skin and soft tissue defects without extensive or radical flap surgery or loss of skin graft.
C1 [Rhee, Seung Chul] Inje Univ, Ilsan Paik Hosp, Dept Plast & Reconstruct Surg, Goyang City 411706, Kyounggi Do, South Korea.
   [Lee, Dong Lark; Ryu, An Young] Hanil Gen Hosp, Dept Plast & Reconstruct Surg, Seoul, South Korea.
C3 Inje University
RP Rhee, SC (通讯作者)，Inje Univ, Ilsan Paik Hosp, Dept Plast & Reconstruct Surg, 2240 Daehwa Dong, Goyang City 411706, Kyounggi Do, South Korea.
EM rheesc@paik.ac.kr
RI Rhee, Seung Chul/I-1278-2019
OI Rhee, Seung Chul/0000-0001-7076-1604
CR Baharestani M, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00607.x
   Borgquist O, 2010, PLAST RECONSTR SURG, V125, P502, DOI 10.1097/PRS.0b013e3181c82e1f
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   de Leon JM, 2009, ADV SKIN WOUND CARE, V22, P122, DOI 10.1097/01.ASW.0000305452.79434.d9
   Hallberg H, 2003, SCAND J PLAST RECONS, V37, P97, DOI 10.1080/02844310310005621
   Hanasono MM, 2007, ANN PLAS SURG, V58, P573, DOI 10.1097/01.sap.0000237638.93453.66
   KIM JS, 2008, J KOREAN SOC PLAST R, V35, P223
   Labler L, 2009, J TRAUMA, V66, P749, DOI 10.1097/TA.0b013e318171971a
   PARK HS, 2003, J KOREAN SOC PLAST R, V30, P585
   Peinemann F, 2008, BMC MED RES METHODOL, V8, DOI 10.1186/1471-2288-8-41
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
   Scherer SS, 2009, PLAST RECONSTR SURG, V124, P1458, DOI 10.1097/PRS.0b013e3181bbc829
   Senchenkov A, 2006, UROLOGY, V67, P416, DOI 10.1016/j.urology.2005.08.037
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   Vikatmaa P, 2008, EUR J VASC ENDOVASC, V36, P438, DOI 10.1016/j.ejvs.2008.06.010
NR 16
TC 20
Z9 25
U1 0
U2 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2011
VL 8
IS 4
BP 406
EP 411
DI 10.1111/j.1742-481X.2011.00813.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 791HB
UT WOS:000292654600012
PM 21595830
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Choi, WW
   McBride, CA
   Kimble, RM
AF Choi, Wilson W.
   McBride, Craig A.
   Kimble, Roy M.
TI Negative pressure wound therapy in the management of neonates with
   complex gastroschisis
SO PEDIATRIC SURGERY INTERNATIONAL
LA English
DT Article
DE Gastroschisis; Neonate; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL-WALL; EXPERIENCE; REDUCTION; SILVER
AB Negative pressure wound therapy (NPWT) is an accepted form of treatment in managing complex wounds in adults and children. It is not as widely used in the neonatal population due to limited clinical experience. We describe the application of the RENASYS (TM) system (Smith and Nephew, UK) in delivering NPWT to four neonates with complex gastroschisis, all of whom achieved successful outcomes.
C1 [Choi, Wilson W.] Univ Queensland, Sch Med, Herston, Qld 4006, Australia.
   [McBride, Craig A.; Kimble, Roy M.] Univ Queensland, Royal Childrens Hosp, Queensland Childrens Med Res Inst, Dept Paediat & Child Hlth, Herston, Qld 4029, Australia.
C3 University of Queensland; Royal Children's Hospital Brisbane; University
   of Queensland
RP Choi, WW (通讯作者)，Univ Queensland, Sch Med, 288 Herston Rd, Herston, Qld 4006, Australia.
EM wilson.choi@uqconnect.edu.au
RI Kimble, Roy/B-4160-2011; /E-7233-2014; McBride, Craig/G-4805-2011
OI Kimble, Roy/0000-0002-2449-7707; McBride, Craig/0000-0001-8377-1748
CR AnvedenHertzberg L, 1996, J PEDIATR SURG, V31, P862, DOI 10.1016/S0022-3468(96)90155-4
   Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Sakata S, 2009, PEDIATR SURG INT, V25, P117, DOI 10.1007/s00383-008-2289-3
   Sandler A, 2004, J PEDIATR SURG, V39, P738, DOI 10.1016/j.jpedsurg.2004.01.040
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   Wright JB, 2002, WOUND REPAIR REGEN, V10, P141, DOI 10.1046/j.1524-475X.2002.10308.x
NR 17
TC 11
Z9 13
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-0358
J9 PEDIATR SURG INT
JI Pediatr. Surg. Int.
PD AUG
PY 2011
VL 27
IS 8
BP 907
EP 911
DI 10.1007/s00383-011-2868-6
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 793KI
UT WOS:000292820200020
PM 21336610
DA 2026-07-24
ER
PT J
AU Hsia, JC
   Moe, KS
AF Hsia, Jennifer C.
   Moe, Kris S.
TI Vacuum-Assisted Closure Therapy for Reconstruction of Soft-Tissue
   Forehead Defects
SO ARCHIVES OF FACIAL PLASTIC SURGERY
LA English
DT Article
ID MANAGEMENT
AB We sought to examine the efficacy of vacuum-assisted closure (VAC) therapy for the reconstruction of full-thickness forehead defects and to determine the appropriate therapeutic strategies for its use. Medical records and photographs were reviewed for 3 patients with full-thickness tissue loss of the forehead region treated with a VAC system. All 3 patients had complete formation of healthy granulation tissue with VAC therapy alone. One patient was treated to full reepithelization of her wound; the other 2 patients underwent successful surgical closure after VAC reduction of the defect. The treatment was well tolerated, with no complications. Although this represents an initial study, it seems that the protocol for VAC therapy presented herein is a reliable technique for the repair of forehead defects that provides excellent functional and aesthetic outcomes. Arch Facial Plast Surg. 2011;13(4):278-282
C1 [Hsia, Jennifer C.; Moe, Kris S.] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle
RP Hsia, JC (通讯作者)，Univ Washington, Dept Otolaryngol Head & Neck Surg, Mail Stop 356515, Seattle, WA 98195 USA.
EM jchsia@u.washington.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baillot R, 2010, EUR J CARDIO-THORAC, V37, P880, DOI 10.1016/j.ejcts.2009.09.023
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   Seternes A, 2010, EUR J VASC ENDOVASC, V40, P60, DOI 10.1016/j.ejvs.2010.02.018
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NR 15
TC 12
Z9 15
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 1521-2491
J9 ARCH FACIAL PLAST S
JI Arch. Facial Plast. Surg.
PD JUL-AUG
PY 2011
VL 13
IS 4
BP 278
EP 282
DI 10.1001/archfacial.2011.40
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 793QU
UT WOS:000292839000010
PM 21768563
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Ingemansson, R
   Malmsjö, M
AF Lindstedt, Sandra
   Ingemansson, Richard
   Malmsjo, Malin
TI A rigid barrier between the heart and sternum protects the heart and
   lungs against rupture during negative pressure wound therapy
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MEDIAN STERNOTOMY INCISION; POSTSTERNOTOMY
   MEDIASTINITIS; AGGRESSIVE MANAGEMENT; EARLY INTERVENTION;
   CARDIAC-SURGERY; EXPERIENCE; INFECTION; GAUZE
AB Objectives: Right ventricular heart rupture is a devastating complication associated with negative pressure wound therapy (NPWT) in cardiac surgery. The use of a rigid barrier has been suggested to offer protection against this lethal complication, by preventing the heart from being drawn up and damaged by the sharp edges of the sternum. The aim of the present study was to investigate whether a rigid barrier protects the heart and lungs against injury during NPWT.
   Methods: Sixteen pigs underwent median sternotomy followed by NPWT at -120 mmHg for 24 hours, in the absence (eight pigs) or presence (eight pigs) of a rigid plastic disc between the heart and the sternal edges. The macroscopic appearance of the heart and lungs was inspected after 12 and 24 hours of NPWT.
   Results: After 24 hours of NPWT at -120 mmHg the area of epicardial petechial bleeding was 11.90 +/- 1.10 cm(2) when no protective disc was used, and 1.15 +/- 0.19 cm(2) when using the disc (p < 0.001). Heart rupture was observed in three of the eight animals treated with NPWT without the disc. Lung rupture was observed in two of the animals, and lung contusion and emphysema were seen in all animals treated with NPWT without the rigid disc. No injury to the heart or lungs was observed in the group of animals treated with NPWT using the rigid disc.
   Conclusion: Inserting a rigid barrier between the heart and the sternum edges offers protection against heart rupture and lung injury during NPWT.
C1 [Lindstedt, Sandra] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   Skane Univ Hosp, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital
RP Lindstedt, S (通讯作者)，Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
EM sandra.lindstedt@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473;
   Ingemansson, Richard/0000-0001-7623-8953
FU Swedish Medical Research Council, Lund University Faculty of Medicine;
   Swedish Government; Swedish Medical Association; Royal Physiographic
   Society in Lund; Ake Wiberg Foundation; Anders Otto Sward Foundation;
   Ulrika Eklund Foundation; Magn Bergvall Foundation; Crafoord Foundation;
   Anna-Lisa and Sven-Erik Nilsson Foundation; Jeansson Foundation; Swedish
   Heart-Lung Foundation; Anna and Edvin Berger's Foundation; Marta
   Lundqvist Foundation; Lars Hierta's Memorial Foundation
FX This study was supported by the Swedish Medical Research Council, Lund
   University Faculty of Medicine, the Swedish Government Grant for
   Clinical Research, Lund University Hospital Research Grants, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the Ake
   Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika Eklund
   Foundation, the Magn Bergvall Foundation, the Crafoord Foundation, the
   Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeansson Foundation, the
   Swedish Heart-Lung Foundation, Anna and Edvin Berger's Foundation, the
   Marta Lundqvist Foundation, and Lars Hierta's Memorial Foundation.
CR Bapat V, 2008, J CARDIAC SURG, V23, P227, DOI 10.1111/j.1540-8191.2008.00595.x
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NR 19
TC 5
Z9 6
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD JUL 8
PY 2011
VL 6
AR 90
DI 10.1186/1749-8090-6-90
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 796PT
UT WOS:000293064800001
PM 21740574
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Honebrink, R
   Buch, R
   Galpin, P
   Burgess, GH
AF Honebrink, Randy
   Buch, Robert
   Galpin, Peter
   Burgess, George H.
TI First Documented Attack on a Live Human by a Cookiecutter Shark
   (Squaliformes, Dalatiidae: Isistius sp.)
SO PACIFIC SCIENCE
LA English
DT Article
ID BRASILIENSIS; BEHAVIOR; BODY
AB An adult long-distance swimmer attempting to cross the 'Alenuihaha Channel between the Hawaiian islands of Hawai'i and Maui was twice bitten by a cookiecutter shark (Squaliformes, Dalatiidae, Isistius sp.). One of these bites presented as an open, round, concave wound typically observed in cookiecutter shark bites inflicted by members of this genus on a broad spectrum of large biota such as marine mammals, elasmobranchs, and bony fishes. The open wound was debrided, subjected to negative pressure wound therapy, and a split thickness skin graft harvested from the left thigh. Postoperative recovery was complicated by delayed healing of the inferior portion of the graft, and cultures and biopsy were normal skin flora and normal tissue, respectively. At 6 months after the incident, the area appeared to be healing with a stable eschar, and by 9 months the wound was healed. Humans entering pelagic waters at twilight and nighttime hours in areas of Isistius sp. occurrence should do so knowing that cookiecutter sharks are a potential danger, particularly during periods of strong moonlight, in areas of man-made illumination, or in the presence of bioluminescent organisms.
C1 [Honebrink, Randy] Hawaii Div Aquat Resources, Honolulu, HI 96813 USA.
   [Buch, Robert; Burgess, George H.] Univ Florida, Florida Program Shark Res, Florida Museum Nat Hist, Gainesville, FL 32611 USA.
   [Buch, Robert] NOAA, Fisheries Serv, NERO, Gloucester, MA 01930 USA.
   [Galpin, Peter] Maui Mem Med Ctr, Wailuku, HI 96793 USA.
C3 State University System of Florida; University of Florida; National
   Oceanic Atmospheric Admin (NOAA) - USA
RP Honebrink, R (通讯作者)，Hawaii Div Aquat Resources, 1151 Punchbowl St, Honolulu, HI 96813 USA.
EM randy.r.honebrink@hawaii.gov
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NR 26
TC 15
Z9 17
U1 0
U2 27
PU UNIV HAWAII PRESS
PI HONOLULU
PA 2840 KOLOWALU ST, HONOLULU, HI 96822 USA
SN 0030-8870
EI 1534-6188
J9 PAC SCI
JI Pac. Sci.
PD JUL
PY 2011
VL 65
IS 3
BP 365
EP 374
DI 10.2984/65.3.365
PG 10
WC Marine & Freshwater Biology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Marine & Freshwater Biology; Zoology
GA 800OM
UT WOS:000293371300006
OA Bronze
DA 2026-07-24
ER
PT J
AU Wettstein, M
   Frieling, T
   Lüthen, R
   Heintges, T
   Niederau, C
   Oette, M
   Vogt, C
   vom Dahl, S
AF Wettstein, M.
   Frieling, T.
   Luethen, R.
   Heintges, T.
   Niederau, C.
   Oette, M.
   Vogt, C.
   vom Dahl, S.
TI Endoscopic Therapy for Leaks in the Gastrointestinal Tract, the Bile
   Ducts and the Pancreas
SO ZEITSCHRIFT FUR GASTROENTEROLOGIE
LA German
DT Review
DE perforations; anastomotic leaks; endoscopic treatment;
   over-the-scope-clip; stenting
ID VACUUM-ASSISTED CLOSURE; THE-SCOPE-CLIP; IATROGENIC COLONIC PERFORATION;
   POSTOPERATIVE ESOPHAGEAL LEAKS; LAPAROSCOPIC CHOLECYSTECTOMY;
   COLONOSCOPIC PERFORATIONS; ANASTOMOTIC LEAKS; RISK-FACTORS; PERCUTANEOUS
   MANAGEMENT; COIL EMBOLIZATION
AB Surgery has been the mainstay of therapy in patients with gastrointestinal perforations, leakage or fistulas. New techniques for endoscopic closure of gastrointestinal perforations provide tools for an effective treatment by less invasive procedures. Temporary placement of covered self-expanding stents is an established therapy for oesophageal perforations and anastomotic leaks. Using conventional endoclips small perforations and leaks in the oesophagus and gastrointestinal tract may be closed. With the new over-the-scope-clips a more effective endoscopic full wall closure is possible in the upper gastrointestinal tract and the rectum. Endoscopically guided endoluminal vacuum therapy using polyurethane sponges is an established method for treating rectal leaks and is now increasingly used also in oesophageal leaks. Biliary leakage following endoscopic or surgical interventions is effectively treated with temporary bile stenting in most cases, but closure using metal stents or coiling may be necessary. Pancreatic leaks are a major therapeutic problem and may require multimodal therapies.
C1 [Wettstein, M.] Klinikum Passau, Med Klin 1, D-94036 Passau, Germany.
   [Frieling, T.] Helios Klinikum Krefeld, Med Klin 2, Krefeld, Germany.
   [Luethen, R.] Marien Hosp, Innere Med Klin, Dusseldorf, Germany.
   [Oette, M.] Krankenhaus Augustinerinnen, Klin Allgemeine Innere Med, Cologne, Germany.
   [Vogt, C.] St Josef Krankenhaus Moers, Innere Med Abt, Moers, Germany.
C3 Helios Kliniken; Marien Hospital Dusseldorf; St. Marien Hospital
RP Wettstein, M (通讯作者)，Klinikum Passau, Med Klin 1, Innstr 76, D-94036 Passau, Germany.
EM matthias.wettstein@klinikum-passau.de
RI vom Dahl, Stephan/AAF-8456-2021
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NR 97
TC 5
Z9 7
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-2771
EI 1439-7803
J9 Z GASTROENTEROL
JI Z. Gastroent.
PD JUN
PY 2011
VL 49
IS 6
BP 740
EP 748
DI 10.1055/s-0031-1273422
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 802YG
UT WOS:000293546300006
PM 21638241
DA 2026-07-24
ER
PT J
AU Demaria, M
   Stanley, BJ
   Hauptman, JG
   Steficek, BA
   Fritz, MC
   Ryan, JM
   Lam, NA
   Moore, TW
   Hadley, HS
AF Demaria, Marco
   Stanley, Bryden J.
   Hauptman, Joe G.
   Steficek, Barbara A.
   Fritz, Michele C.
   Ryan, John M.
   Lam, Nathaniel A.
   Moore, Trevor W.
   Hadley, Heather S.
TI Effects of Negative Pressure Wound Therapy on Healing of Open Wounds in
   Dogs
SO VETERINARY SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE;
   POSTSTERNOTOMY MEDIASTINITIS; EXTREMITY WOUNDS; MANAGEMENT;
   TRANSDUCTION; GAUZE; COST; RECONSTRUCTION
AB Objective: To compare the effect of negative pressure wound therapy (NPWT) with standard-of-care management on healing of acute open wounds in dogs.
   Study Design: Prospective, controlled, experimental study.
   Animals: Adult dogs (n = 10).
   Methods: Full-thickness 4cm x 2 cm wounds were surgically created on each antebrachium and in each dog were randomized to receive either NPWT or standard wound dressings (CON) for 21 days. Dressing changes and wound evaluations were made at 8 time points. First appearance of granulation tissue, smoothness of granulation tissue, exuberance, percent epithelialization, and percent contraction were compared. Biopsies for histopathology were taken, and histologic scores determined, at 5 time points, and aerobic bacterial wound cultures performed at 2 time points.
   Results: Granulation tissue appeared significantly earlier, and was smoother and less exuberant in NPWT wounds compared with CON wounds. Percent contraction in NPWT wounds was less than CON wounds after Day 7. Percent epithelialization in NPWT wounds was less than CON wounds on Days 11, 16, 18, and 21. Histologic scores for acute inflammation were higher in NPWT on Day 3, and lower on Day 7, than CON wounds. Bacterial load was higher in NPWT on Day 7.
   Conclusion: NPWT accelerated appearance of smooth, nonexuberant granulation tissue; however, prolonged use of NPWT impaired wound contraction and epithelialization.
C1 [Demaria, Marco; Stanley, Bryden J.; Hauptman, Joe G.; Fritz, Michele C.; Lam, Nathaniel A.; Moore, Trevor W.; Hadley, Heather S.] Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
   [Steficek, Barbara A.] Michigan State Univ, Coll Vet Med, Diagnost Ctr Populat & Anim Hlth, E Lansing, MI 48824 USA.
   [Ryan, John M.] Univ Edinburgh, Royal Dick Sch Vet Studies, Edinburgh EH9 1QH, Midlothian, Scotland.
C3 Michigan State University; Michigan State University; University of
   Edinburgh
RP Stanley, BJ (通讯作者)，Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
EM stanle32@cvm.msu.edu
OI Fritz, Michele/0000-0002-4146-2469
FU College of Veterinary Medicine, Michigan State University, East Lansing,
   MI.
FX Funded by an Endowed Research Funds grant, College of Veterinary
   Medicine, Michigan State University, East Lansing, MI.
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NR 83
TC 66
Z9 78
U1 0
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD AUG
PY 2011
VL 40
IS 6
BP 658
EP 669
DI 10.1111/j.1532-950X.2011.00849.x
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 803GK
UT WOS:000293569600002
PM 21770975
DA 2026-07-24
ER
PT J
AU Soares, MO
   Bojke, L
   Dumville, J
   Iglesias, C
   Cullum, N
   Claxton, K
AF Soares, Marta O.
   Bojke, Laura
   Dumville, Jo
   Iglesias, Cynthia
   Cullum, Nicky
   Claxton, Karl
TI Methods to elicit experts' beliefs over uncertain quantities:
   application to a cost effectiveness transition model of negative
   pressure wound therapy for severe pressure ulceration
SO STATISTICS IN MEDICINE
LA English
DT Article
DE cost-effectiveness; expert; elicitation; decision analytic models;
   negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; BAYESIAN-ANALYSIS; CARE; PATIENT; TRIAL;
   DISTRIBUTIONS; PROBABILITIES; OPINION; DESIGN
AB We can use decision models to estimate cost effectiveness, quantify uncertainty regarding the adoption decision and provide estimates of the value of further research. In many cases, the existence of only limited data with which to populate a decision model can mean that a cost-effectiveness analysis either does not proceed or may misrepresent the degree of uncertainty associated with model inputs. An example is the case of negative pressure wound therapy (NPWT) used to treat severe pressure ulceration, for which the evidence base is limited and sparse. There is, however, substantial practical experience of using this treatment and its comparators. We can capture this knowledge quantitatively to inform a cost-effectiveness model by eliciting beliefs from experts.
   This paper describes the design and conduct of an elicitation exercise to generate estimates of multiple uncertain model inputs and validate analytical assumptions for a decision model on the use of NPWT. In designing the exercise, the primary focus was the use of elicitation to inform decision models (multistate models), where representations of uncertain beliefs need to be probabilistically coherent. This paper demonstrates that it is feasible to collect formally elicited evidence to inform decision models. Copyright (C) 2011 John Wiley & Sons, Ltd.
C1 [Soares, Marta O.; Bojke, Laura; Claxton, Karl] Univ York, Ctr Hlth Econ, York YO10 5DD, N Yorkshire, England.
   [Dumville, Jo; Iglesias, Cynthia; Cullum, Nicky] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England.
C3 University of York - UK; University of York - UK
RP Soares, MO (通讯作者)，Univ York, Ctr Hlth Econ, Alcuin A Block, York YO10 5DD, N Yorkshire, England.
EM marta.soares@york.ac.uk
RI Soares, Marta Ferreira Oliveira/HJH-3434-2023; Dumville, Jo/O-7867-2014;
   Cullum, Nicky/F-2438-2011
OI Soares, Marta Ferreira Oliveira/0000-0003-1579-8513; Dumville,
   Jo/0000-0002-6546-3685; Cullum, Nicky/0000-0003-2631-123X
FU Medical Research Council [G0501814, MC_U145079308, G0501892] Funding
   Source: Medline; MRC [MC_U145079308, G0501814, G0501892] Funding Source:
   UKRI; Medical Research Council [G0501814, G0501892, MC_U145079308]
   Funding Source: researchfish
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NR 60
TC 43
Z9 48
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0277-6715
EI 1097-0258
J9 STAT MED
JI Stat. Med.
PD AUG 30
PY 2011
VL 30
IS 19
BP 2363
EP 2380
DI 10.1002/sim.4288
PG 18
WC Mathematical & Computational Biology; Public, Environmental &
   Occupational Health; Medical Informatics; Medicine, Research &
   Experimental; Statistics & Probability
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Mathematical & Computational Biology; Public, Environmental &
   Occupational Health; Medical Informatics; Research & Experimental
   Medicine; Mathematics
GA 805ON
UT WOS:000293738600003
PM 21748773
DA 2026-07-24
ER
PT J
AU Palm, HG
   Hauer, T
   Simon, C
   Willy, C
AF Palm, H. -G.
   Hauer, T.
   Simon, C.
   Willy, C.
TI Vacuum-assisted closure of head and neck wounds
SO HNO
LA German
DT Article
DE Vacuum-assisted closure; Head and neck surgery; Wounds; Soft tissue
   injury; Military medicine
ID NEGATIVE-PRESSURE DRESSINGS; SOFT-TISSUE WOUNDS; THERAPY; MANAGEMENT;
   RECONSTRUCTION; MILITARY; SURGERY; DEFECTS; DEVICE; SYSTEM
AB Since the early 1990s, vacuum-assisted closure (VAC) therapy has been used to treat acute and chronic wounds in almost all disciplines of surgery in Germany. Taking this into consideration, the use of vacuum therapy in the area of head and neck surgery was examined.
   A literature review using MEDLINE (with PubMed) and EMBASE as well as a Cochrane search was performed on 15 December 2010. Search terms included "vacuum therapy", "vacuum-assisted closure", "V.A.C.", "VAC", "(topical) negative pressure (wound therapy)".
   There were 1,502 peer-reviewed articles about "vacuum therapy" concerning all medical fields in literature. There were a total of 37 publications from the discipline of head and neck surgery (538 patients). Although benefits for the patients are consistently reported, these results are usually presented only in case reports or case series (evidence level IV and V). Positive results are mainly observed for the treatment of lifting defects in reconstructive surgery and for the treatment of acute and chronic soft tissue defects of the neck. Only little experience exists in the vacuum therapy of war wounds in the head and neck region.
   Due to its advantages (i.e., hygienic temporary wound care with support of the continuous decontamination, wound drainage, promotion of granulation tissue formation, and effective wound conditioning), VAC is an integral and indispensable part of modern wound treatment. Analogous to this general experience, a benefit must also be assumed for head and neck wounds. High-quality and reliable studies on the use of VAC must be performed to verify this observation and the future reimbursement of in- and outpatient wound VAC treatment.
C1 [Willy, C.] Bundeswehrkrankenhaus Ulm, Chirurg Zentrum, D-89081 Ulm, Germany.
   [Palm, H. -G.] Bundeswehrkrankenhaus Ulm, Klin Unfallchirurg & Orthopadie Controlling & Qua, D-89081 Ulm, Germany.
   [Hauer, T.] Bundeswehrkrankenhaus Ulm, Klin Allgemein Viszeral & Thoraxchirurg, D-89081 Ulm, Germany.
   [Simon, C.] Univ HNO Klin Heidelberg, Heidelberg, Germany.
C3 Ulm University; Military Hospital Ulm; Ulm University; Military Hospital
   Ulm; Ulm University; Military Hospital Ulm; Ruprecht Karls University
   Heidelberg
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Ulm, Chirurg Zentrum, Oberer Eselsberg 40, D-89081 Ulm, Germany.
EM ChristianWilly@Bundeswehr.org
RI /AAJ-3174-2021
OI Simon, Christian/0000-0002-4156-9143
CR Andrews BT, 2008, ANN OTO RHINOL LARYN, V117, P298, DOI 10.1177/000348940811700410
   Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Baer D G, 2009, J R Army Med Corps, V155, P327
   Dhir K, 2009, LARYNGOSCOPE, V119, P54, DOI 10.1002/lary.20000
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   Geiger S, 2008, PLAST RECONSTR SURG, V122, P146, DOI 10.1097/PRS.0b013e3181773d19
   *GEM BUND, 2011, SUCHB VAK
   Halama D, 2004, ZBL CHIR, V129, pS53, DOI 10.1055/s-2004-822669
   Horch RE, 2006, ZBL CHIR, V131, pS44, DOI 10.1055/s-2006-921462
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   Leininger BE, 2006, J TRAUMA, V61, P1207, DOI 10.1097/01.ta.0000241150.15342.da
   Li Jin-Qing, 2008, Zhonghua Shao Shang Za Zhi, V24, P13
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   Nouraei S A R, 2003, J Wound Care, V12, P147
   Pirela-Cruz MA, 2008, J HAND THER, V21, P196, DOI 10.1197/j.jht.2007.12.007
   Pollak Andrew N, 2010, J Surg Orthop Adv, V19, P44
   Rispoli DM, 2010, J TRAUMA, V68, P1247, DOI 10.1097/TA.0b013e3181d3cc3c
   Rosenthal EL, 2005, HEAD NECK-J SCI SPEC, V27, P970, DOI 10.1002/hed.20265
   Schipper J, 2006, ZBL CHIR, V131, pS141, DOI 10.1055/s-2006-921507
   Sheppard FR, 2010, AM J SURG, V200, P489, DOI 10.1016/j.amjsurg.2010.03.001
   Steiert AE, 2009, J PLAST RECONSTR AES, V62, P675, DOI 10.1016/j.bjps.2007.09.041
   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
   WILLY C, 2005, VAKUUMTHERAPIE GRUND, P43
   WILLY C, 2005, VAKUUMTHERAPIE GRUND, P9
   WILLY C, 2005, VAKUUMTHERAPIE GRUND, P3
NR 32
TC 11
Z9 12
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0017-6192
EI 1433-0458
J9 HNO
JI HNO
PD AUG
PY 2011
VL 59
IS 8
BP 819
EP +
DI 10.1007/s00106-011-2364-2
PG 11
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 806FN
UT WOS:000293791800010
PM 21769576
DA 2026-07-24
ER
PT J
AU Hill, SM
   Elwood, ET
AF Hill, Sean M.
   Elwood, Eric T.
TI Pediatric Lower Extremity Mower Injuries
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE lower extremity; reconstruction; power mower; pediatric
ID PRESSURE WOUND THERAPY; SOFT-TISSUE INJURIES; CLOSURE; FRACTURES;
   CHILDREN; BRIDGE; TIBIA
AB Lawn mower injuries in children represent an unfortunate common problem to the plastic reconstructive surgeon. There are approximately 68,000 per year reported in the United States. Compounding this problem is the fact that a standard treatment algorithm does not exist. This study follows a series of 7 pediatric patients treated for lower extremity mower injuries by a single plastic surgeon. The extent of soft tissue injury varied. All patients were treated with negative pressure wound therapy as a bridge to definitive closure. Of the 7 patients, 4 required skin grafts, 1 required primary closure, 1 underwent a lower extremity amputation secondary to wounds, and 1 was repaired using a cross-leg flap. Function limitations were minimal for all of our patients after reconstruction. Our basic treatment algorithm is presented with initial debridement followed by the simplest method possible for wound closure using negative pressure wound therapy, if necessary.
C1 [Hill, Sean M.; Elwood, Eric T.] Univ Illinois, Coll Med, Peoria, IL 61656 USA.
C3 University of Illinois System; University of Illinois Peoria
RP Hill, SM (通讯作者)，Univ Illinois, Coll Med, Peoria, IL 61656 USA.
EM shill8@uic.edu
CR Bollero D, 2007, WOUND REPAIR REGEN, V15, P589, DOI 10.1111/j.1524-475X.2007.00267.x
   Bull MJ, 2001, PEDIATRICS, V107, DOI 10.1542/peds.107.6.e106
   Chariker ME, 2009, PLAST RECONSTR SURG, V123, P1510, DOI 10.1097/PRS.0b013e3181a20563
   Costilla V, 2006, ANN EMERG MED, V47, P567, DOI 10.1016/j.annemergmed.2006.02.020
   Dedmond BT, 2007, J ORTHOP TRAUMA, V21, P11, DOI 10.1097/BOT.0b013e31802cbc54
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   Gordis L., 2004, EPIDEMIOLOGY, V3rd
   Herscovici D, 2003, J ORTHOP TRAUMA, V17, P683, DOI 10.1097/00005131-200311000-00004
   Ong YS, 2010, PLAST RECONSTR SURG, V125, P582, DOI 10.1097/PRS.0b013e3181c82ed1
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   Rutherford G, 2003, HAZARD SCREENING REP
NR 14
TC 7
Z9 8
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD SEP
PY 2011
VL 67
IS 3
BP 279
EP 287
DI 10.1097/SAP.0b013e3181fab9ba
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 806QW
UT WOS:000293826100018
PM 21508814
DA 2026-07-24
ER
PT J
AU Erba, P
   Adini, A
   Demcheva, M
   Valeri, CR
   Orgill, DP
AF Erba, Paolo
   Adini, Avner
   Demcheva, Marina
   Valeri, C. Robert
   Orgill, Dennis P.
TI Poly-N-Acetyl Glucosamine Fibers Are Synergistic With
   Vacuum-Assisted Closure in Augmenting the Healing Response of Diabetic
   Mice
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Poly-N-acetyl glucosamine fibers; VAC; Wound healing; Diabetic mice
ID WOUND THERAPY; BANDAGE; CULTURE; LOAD
AB Background: Vacuum-assisted closure (VAC) has become the preferred modality to treat many complex wounds but could be further improved by methods that minimize bleeding and facilitate wound epithelialization. Short fiber poly-N-acetyl glucosamine nanofibers (sNAG) are effective hemostatic agents that activate platelets and facilitate wound epithelialization. We hypothesized that sNAG used in combination with the VAC device could be synergistic in promoting wound healing while minimizing the risk of bleeding.
   Methods: Membranes consisting entirely of sNAG nanofibers were applied immediately to dorsal excisional wounds of db/db mice followed by application of the VAC device. Wound healing kinetics, angiogenesis, and wound-related growth factor expression were measured.
   Results: The application of sNAG membranes to wounds 24 hours before application of the VAC device was associated with a significant activation of wounds (expression of PDGF, TGF beta, EGF), superior granulation tissue formation rich in Collagen I as well as superior wound epithelialization (8.6% +/- 0.3% vs. 1.8% +/- 1.1% of initial wound size) and wound contraction.
   Conclusions: The application of sNAG fiber-containing membranes before the application of the polyurethane foam interface of VAC devices leads to superior healing in db/db mice and represents a promising wound healing adjunct that can also reduce the risk of bleeding complications.
C1 [Erba, Paolo] Univ Basel Hosp, Dept Plast Reconstruct & Aesthet Surg, Div Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
   [Erba, Paolo] Univ Lausanne Hosp, Div Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
   [Adini, Avner] Harvard Univ, Childrens Hosp, Sch Med, Vasc Biol Program,Dept Surg, Boston, MA 02115 USA.
   [Orgill, Dennis P.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast Surg, Boston, MA 02115 USA.
   [Demcheva, Marina] Marine Polymer Technol, Danvers, MA USA.
   [Valeri, C. Robert] USN, Blood Res Lab Inc, Boston, MA USA.
C3 University of Basel; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Boston Children's Hospital; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard Medical School; United States Department of Defense;
   United States Navy
RP Erba, P (通讯作者)，Univ Basel Hosp, Dept Plast Reconstruct & Aesthet Surg, Div Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
EM erbapaolo@hotmail.com
RI Adini, Avner/AAD-6141-2022; Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
FU Marine Polymer Technologies, Inc., Danvers, MA; Marine Polymers, Inc.;
   Kinetic Concepts Inc. (KCI)
FX The Tissue Engineering and Wound Healing Laboratory at Brigham and
   Women's Hospital acknowledges Marine Polymer Technologies, Inc.,
   Danvers, MA, for their material and financial support of this project.
   Supported, in part, by a research contract from Marine Polymers, Inc. to
   Brigham and Women's Hospital. During the time of the experiment, Dr.
   Orgill was a principal investigator for a research study funded by
   Kinetic Concepts Inc. (KCI) to Brigham and Women's Hospital.
CR Aarabi S, 2007, FASEB J, V21, P3250, DOI 10.1096/fj.07-8218com
   Erba P, 2008, J PLAST RECONSTR AES, V61, P852, DOI 10.1016/j.bjps.2007.10.080
   Fischer TH, 2007, J BIOMED MATER RES A, V80A, P167, DOI 10.1002/jbm.a.30877
   Ikeda Y, 2002, J SURG RES, V102, P215, DOI 10.1006/jsre.2001.6323
   Kelly DJ, 2005, J BIOMECH, V38, P1413, DOI 10.1016/j.jbiomech.2004.06.026
   King DR, 2004, J TRAUMA, V57, P756, DOI 10.1097/01.TA.0000147501.64610.AFS
   LAMBERT CA, 1992, LAB INVEST, V66, P444
   MARKS MW, 1987, CLIN PLAST SURG, V14, P455
   McFetridge PS, 2007, ASAIO J, V53, P623, DOI 10.1097/MAT.0b013e31812f3b7e
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Ogawa R, 2008, MED HYPOTHESES, V71, P493, DOI 10.1016/j.mehy.2008.05.020
   Orgill DP, 2004, WOUNDS, p15S
   Orgill DP, 2005, WOUNDS, p39S
   Pietramaggiori G, 2008, J TRAUMA, V64, P803, DOI 10.1097/01.ta.0000244382.13937.a8
   Pietramaggiori G, 2007, ANN SURG, V246, P896, DOI 10.1097/SLA.0b013e3180caa47f
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Scherer SS, 2009, ANN SURG, V250, P322, DOI 10.1097/SLA.0b013e3181ae9d45
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
   Vournakis JN, 2004, J TRAUMA, V57, pS2, DOI 10.1097/01.TA.0000136741.66698.9D
   Vournakis JN, 2003, J SURG RES, V113, P1, DOI 10.1016/S0022-4804(03)00161-6
   Watanabe S, 2005, J BIOSCI BIOENG, V100, P105, DOI 10.1263/jbb.100.105
NR 22
TC 9
Z9 10
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD AUG
PY 2011
VL 71
SU 1
BP S187
EP S193
DI 10.1097/TA.0b013e318225583c
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 806WZ
UT WOS:000293849000007
PM 21814117
DA 2026-07-24
ER
PT J
AU Hospenthal, DR
   Murray, CK
   Andersen, RC
   Bell, RB
   Calhoun, JH
   Cancio, LC
   Cho, JM
   Chung, KK
   Clasper, JC
   Colyer, MH
   Conger, NG
   Costanzo, GP
   Crouch, HK
   Curry, TK
   D'Avignon, LC
   Dorlac, WC
   Dunne, JR
   Eastridge, BJ
   Ficke, JR
   Fleming, ME
   Forgione, MA
   Green, AD
   Hale, RG
   Hayes, DK
   Holcomb, JB
   Hsu, JR
   Kester, KE
   Martin, GJ
   Moores, LE
   Obremskey, WT
   Petersen, K
   Renz, EM
   Saffle, JR
   Solomkin, JS
   Sutter, DE
   Tribble, DR
   Wenke, JC
   Whitman, TJ
   Wiesen, AR
   Wortmann, GW
AF Hospenthal, Duane R.
   Murray, Clinton K.
   Andersen, Romney C.
   Bell, R. Bryan
   Calhoun, Jason H.
   Cancio, Leopoldo C.
   Cho, John M.
   Chung, Kevin K.
   Clasper, Jon C.
   Colyer, Marcus H.
   Conger, Nicholas G.
   Costanzo, George P.
   Crouch, Helen K.
   Curry, Thomas K.
   D'Avignon, Laurie C.
   Dorlac, Warren C.
   Dunne, James R.
   Eastridge, Brian J.
   Ficke, James R.
   Fleming, Mark E.
   Forgione, Michael A.
   Green, Andrew D.
   Hale, Robert G.
   Hayes, David K.
   Holcomb, John B.
   Hsu, Joseph R.
   Kester, Kent E.
   Martin, Gregory J.
   Moores, Leon E.
   Obremskey, William T.
   Petersen, Kyle
   Renz, Evan M.
   Saffle, Jeffrey R.
   Solomkin, Joseph S.
   Sutter, Deena E.
   Tribble, David R.
   Wenke, Joseph C.
   Whitman, Timothy J.
   Wiesen, Andrew R.
   Wortmann, Glenn W.
TI Executive Summary: Guidelines for the Prevention of Infections
   Associated With Combat-Related Injuries: 2011 Update Endorsed by the
   Infectious Diseases Society of America and the Surgical Infection
   Society
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Review
DE Guidelines; Infection; Combat; Trauma; Prevention
AB Despite advances in resuscitation and surgical management of combat wounds, infection remains a concerning and potentially preventable complication of combat-related injuries. Interventions currently used to prevent these infections have not been either clearly defined or subjected to rigorous clinical trials. Current infection prevention measures and wound management practices are derived from retrospective review of wartime experiences, from civilian trauma data, and from in vitro and animal data. This update to the guidelines published in 2008 incorporates evidence that has become available since 2007. These guidelines focus on care provided within hours to days of injury, chiefly within the combat zone, to those combat-injured patients with open wounds or burns. New in this update are a consolidation of antimicrobial agent recommendations to a backbone of high-dose cefazolin with or without metronidazole for most postinjury indications and recommendations for redosing of antimicrobial agents, for use of negative pressure wound therapy, and for oxygen supplementation in flight.
C1 [Hospenthal, Duane R.] San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, Ft Sam Houston, TX 78234 USA.
   [Cancio, Leopoldo C.; Chung, Kevin K.; Costanzo, George P.; Eastridge, Brian J.; Hale, Robert G.; Hsu, Joseph R.; Renz, Evan M.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Andersen, Romney C.; Colyer, Marcus H.; Dunne, James R.; Fleming, Mark E.; Martin, Gregory J.; Whitman, Timothy J.; Wortmann, Glenn W.] Walter Reed Natl Mil Med Ctr Bethesda, Bethesda, MD USA.
   [Tribble, David R.] Infect Dis Clin Res Program, Bethesda, MD USA.
   [Bell, R. Bryan] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
   [Calhoun, Jason H.] Ohio State Univ, Columbus, OH 43210 USA.
   [Cho, John M.] Landstuhl Reg Med Ctr, Landstuhl, Germany.
   [Clasper, Jon C.; Green, Andrew D.] Royal Ctr Def Med, Inst Res & Dev, Birmingham, W Midlands, England.
   [Conger, Nicholas G.; Forgione, Michael A.] Keesler Med Ctr, Keesler AFB, MS USA.
   [Curry, Thomas K.] Madigan Army Med Ctr, Ft Lewis, WA USA.
   [Wiesen, Andrew R.] Western Reg Med Command, Ft Lewis, WA USA.
   [D'Avignon, Laurie C.] USAF, Med Support Agcy, Lackland AFB, TX USA.
   [Dorlac, Warren C.; Solomkin, Joseph S.] Univ Cincinnati, Cincinnati, OH USA.
   [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX USA.
   [Kester, Kent E.] Walter Reed Army Inst Res, Silver Spring, MD USA.
   [Moores, Leon E.] Kimbrough Ambulatory Care Ctr, Ft George G Meade, MD USA.
   [Obremskey, William T.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
   [Petersen, Kyle] USN, Med Res Ctr, Silver Spring, MD USA.
   [Saffle, Jeffrey R.] Univ Utah, Salt Lake City, UT USA.
C3 Brooke Army Medical Center; Walter Reed National Military Medical
   Center; Oregon Health & Science University; University System of Ohio;
   Ohio State University; Landstuhl Regional Medical Center; University of
   Birmingham; Royal Centre for Defence Medicine; Madigan Army Medical
   Center; United States Department of Defense; United States Air Force;
   University System of Ohio; University of Cincinnati; University of Texas
   System; University of Texas Health Science Center Houston; Walter Reed
   Army Institute of Research (WRAIR); United States Department of Defense;
   United States Army; Vanderbilt University; United States Department of
   Defense; United States Navy; Utah System of Higher Education; University
   of Utah
RP Hospenthal, DR (通讯作者)，San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM duane.hospenthal@us.army.mil
RI Martin, Gregory/CAG-8518-2022; /AGJ-2398-2022; Fleming,
   Mark/HJA-3208-2022; Obremskey, William/HRA-4704-2023; Kester,
   Kent/AAF-8235-2020
OI holcomb, john/0000-0001-8312-9157; Fleming, Mark/0000-0002-4753-2632;
   Obremskey, William/0000-0002-8942-1842; Kester,
   Kent/0000-0002-5056-0802; Solomkin, Joseph/0000-0001-6382-4902;
   Andersen, Romney/0009-0000-3507-7612; Bell, R.
   Bryan/0000-0002-3775-109X; Petersen, Kyle/0000-0003-2429-5002;
   Hospenthal, Duane/0000-0003-3354-8075; Hsu, Joseph/0000-0001-9341-2554
FU US Army Medical Command
FX Financial support for the consensus conference and publication of the
   Journal of Trauma supplement was provided by the US Army Medical
   Command.
CR D'Avignon LC, 2011, J TRAUMA, V71, pS282, DOI 10.1097/TA.0b013e318227adc2
   Forgione MA, 2011, J TRAUMA, V71, pS258, DOI 10.1097/TA.0b013e318227ad86
   Hospenthal DR, 2011, J TRAUMA, V71, pS290, DOI 10.1097/TA.0b013e318227add8
   Martin GJ, 2011, J TRAUMA, V71, pS270, DOI 10.1097/TA.0b013e318227adae
   Murray CK, 2011, J TRAUMA, V71, pS235, DOI 10.1097/TA.0b013e318227ac5f
   Petersen K, 2011, J TRAUMA, V71, pS264, DOI 10.1097/TA.0b013e318227ad9a
NR 6
TC 16
Z9 17
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD AUG
PY 2011
VL 71
SU 2
BP S202
EP S209
DI 10.1097/TA.0b013e318227ac37
PG 8
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 806XB
UT WOS:000293849300002
PM 21814088
DA 2026-07-24
ER
PT J
AU Hospenthal, DR
   Murray, CK
   Andersen, RC
   Bell, RB
   Calhoun, JH
   Cancio, LC
   Cho, JM
   Chung, KK
   Clasper, JC
   Colyer, MH
   Conger, NG
   Costanzo, GP
   Crouch, HK
   Curry, TK
   D'Avignon, LC
   Dorlac, WC
   Dunne, JR
   Eastridge, BJ
   Ficke, JR
   Fleming, ME
   Forgione, MA
   Green, AD
   Hale, RG
   Hayes, DK
   Holcomb, JB
   Hsu, JR
   Kester, KE
   Martin, GJ
   Moores, LE
   Obremskey, WT
   Petersen, K
   Renz, EM
   Saffle, JR
   Solomkin, JS
   Sutter, DE
   Tribble, DR
   Wenke, JC
   Whitman, TJ
   Wiesen, AR
   Wortmann, GW
AF Hospenthal, Duane R.
   Murray, Clinton K.
   Andersen, Romney C.
   Bell, R. Bryan
   Calhoun, Jason H.
   Cancio, Leopoldo C.
   Cho, John M.
   Chung, Kevin K.
   Clasper, Jon C.
   Colyer, Marcus H.
   Conger, Nicholas G.
   Costanzo, George P.
   Crouch, Helen K.
   Curry, Thomas K.
   D'Avignon, Laurie C.
   Dorlac, Warren C.
   Dunne, James R.
   Eastridge, Brian J.
   Ficke, James R.
   Fleming, Mark E.
   Forgione, Michael A.
   Green, Andrew D.
   Hale, Robert G.
   Hayes, David K.
   Holcomb, John B.
   Hsu, Joseph R.
   Kester, Kent E.
   Martin, Gregory J.
   Moores, Leon E.
   Obremskey, William T.
   Petersen, Kyle
   Renz, Evan M.
   Saffle, Jeffrey R.
   Solomkin, Joseph S.
   Sutter, Deena E.
   Tribble, David R.
   Wenke, Joseph C.
   Whitman, Timothy J.
   Wiesen, Andrew R.
   Wortmann, Glenn W.
TI Guidelines for the Prevention of Infections Associated With
   Combat-Related Injuries: 2011 Update Endorsed by the Infectious Diseases
   Society of America and the Surgical Infection Society
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Review
DE Guidelines; Infection; Combat; Trauma; Prevention
ID OPERATION-IRAQI-FREEDOM; HYPERBARIC-OXYGEN THERAPY; SMALL-FRAGMENT
   WOUNDS; PENETRATING CRANIOCEREBRAL INJURIES; RANDOMIZED CLINICAL-TRIAL;
   INTRAOPERATIVE BLOOD-LOSS; VACUUM-ASSISTED CLOSURE; SEVERE OPEN
   FRACTURES; OPEN TIBIA FRACTURES; COMPLICATED INTRAABDOMINAL INFECTIONS
AB Despite advances in resuscitation and surgical management of combat wounds, infection remains a concerning and potentially preventable complication of combat-related injuries. Interventions currently used to prevent these infections have not been either clearly defined or subjected to rigorous clinical trials. Current infection prevention measures and wound management practices are derived from retrospective review of wartime experiences, from civilian trauma data, and from in vitro and animal data. This update to the guidelines published in 2008 incorporates evidence that has become available since 2007. These guidelines focus on care provided within hours to days of injury, chiefly within the combat zone, to those combat-injured patients with open wounds or burns. New in this update are a consolidation of antimicrobial agent recommendations to a backbone of high-dose cefazolin with or without metronidazole for most postinjury indications, and recommendations for redosing of antimicrobial agents, for use of negative pressure wound therapy, and for oxygen supplementation in flight.
C1 [Hospenthal, Duane R.] San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, Ft Sam Houston, TX 78234 USA.
   [Cancio, Leopoldo C.; Chung, Kevin K.; Costanzo, George P.; Eastridge, Brian J.; Hale, Robert G.; Hsu, Joseph R.; Renz, Evan M.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Andersen, Romney C.; Colyer, Marcus H.; Dunne, James R.; Fleming, Mark E.; Martin, Gregory J.; Whitman, Timothy J.; Wortmann, Glenn W.] Walter Reed Natl Mil Med Ctr Bethesda, Bethesda, MD USA.
   [Tribble, David R.] Infect Dis Clin Res Program, Bethesda, MD USA.
   [Bell, R. Bryan] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
   [Calhoun, Jason H.] Ohio State Univ, Columbus, OH 43210 USA.
   [Cho, John M.] Landstuhl Reg Med Ctr, Landstuhl, Germany.
   [Clasper, Jon C.; Green, Andrew D.] Royal Ctr Def Med, Inst Res & Dev, Birmingham, W Midlands, England.
   [Conger, Nicholas G.; Forgione, Michael A.] Keesler Med Ctr, Keesler AFB, MS USA.
   [Curry, Thomas K.] Madigan Army Med Ctr, Ft Lewis, WA USA.
   [Wiesen, Andrew R.] Western Reg Med Command, Ft Lewis, WA USA.
   [D'Avignon, Laurie C.] USAF, Med Support Agcy, Lackland AFB, TX USA.
   [Dorlac, Warren C.; Solomkin, Joseph S.] Univ Cincinnati, Cincinnati, OH USA.
   [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX USA.
   [Kester, Kent E.] Walter Reed Army Inst Res, Silver Spring, MD USA.
   [Moores, Leon E.] Kimbrough Ambulatory Care Ctr, Ft George G Meade, MD USA.
   [Obremskey, William T.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
   [Petersen, Kyle] USN, Med Res Ctr, Silver Spring, MD USA.
   [Saffle, Jeffrey R.] Univ Utah, Salt Lake City, UT USA.
C3 Brooke Army Medical Center; Walter Reed National Military Medical
   Center; Oregon Health & Science University; University System of Ohio;
   Ohio State University; Landstuhl Regional Medical Center; University of
   Birmingham; Royal Centre for Defence Medicine; Madigan Army Medical
   Center; United States Department of Defense; United States Air Force;
   University System of Ohio; University of Cincinnati; University of Texas
   System; University of Texas Health Science Center Houston; Walter Reed
   Army Institute of Research (WRAIR); United States Department of Defense;
   United States Army; Vanderbilt University; United States Department of
   Defense; United States Navy; Utah System of Higher Education; University
   of Utah
RP Hospenthal, DR (通讯作者)，San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM duane.hospenthal@us.army.mil
RI Martin, Gregory/CAG-8518-2022; /AGJ-2398-2022; Kester,
   Kent/AAF-8235-2020; Fleming, Mark/HJA-3208-2022; Obremskey,
   William/HRA-4704-2023
OI Kester, Kent/0000-0002-5056-0802; holcomb, john/0000-0001-8312-9157;
   Bell, R. Bryan/0000-0002-3775-109X; Andersen,
   Romney/0009-0000-3507-7612; Solomkin, Joseph/0000-0001-6382-4902;
   Fleming, Mark/0000-0002-4753-2632; Hsu, Joseph/0000-0001-9341-2554;
   Obremskey, William/0000-0002-8942-1842; Petersen,
   Kyle/0000-0003-2429-5002; Hospenthal, Duane/0000-0003-3354-8075
FU US Army Medical Command
FX Financial support for the consensus conference and publication of the
   Journal of Trauma supplement was provided by the US Army Medical
   Command.
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NR 288
TC 128
Z9 137
U1 1
U2 31
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD AUG
PY 2011
VL 71
SU 2
BP S210
EP S234
DI 10.1097/TA.0b013e318227ac4b
PG 25
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 806XB
UT WOS:000293849300003
PM 21814089
DA 2026-07-24
ER
PT J
AU Murray, CK
   Obremskey, WT
   Hsu, JR
   Andersen, RC
   Calhoun, JH
   Clasper, JC
   Whitman, TJ
   Curry, TK
   Fleming, ME
   Wenke, JC
   Ficke, JR
AF Murray, Clinton K.
   Obremskey, William T.
   Hsu, Joseph R.
   Andersen, Romney C.
   Calhoun, Jason H.
   Clasper, Jon C.
   Whitman, Timothy J.
   Curry, Thomas K.
   Fleming, Mark E.
   Wenke, Joseph C.
   Ficke, James R.
CA Prevention Combat-Related Infect
TI Prevention of Infections Associated With Combat-Related Extremity
   Injuries
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Review
DE Extremity; Infection; Prevention; Iraq; Afghanistan
ID OPERATION-IRAQI-FREEDOM; HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND
   THERAPY; SEVERE OPEN FRACTURES; SMALL-FRAGMENT WOUNDS; OPEN TIBIA
   FRACTURES; RESISTANT STAPHYLOCOCCUS-AUREUS; INTRAOPERATIVE BLOOD-LOSS;
   VACUUM-ASSISTED CLOSURE; SUPPLEMENTAL PERIOPERATIVE OXYGEN
AB During combat operations, extremities continue to be the most common sites of injury with associated high rates of infectious complications. Overall, similar to 15% of patients with extremity injuries develop osteomyelitis, and similar to 17% of those infections relapse or recur. The bacteria infecting these wounds have included multidrug-resistant bacteria such as Acinetobacter baumannii, Pseudomonas aeruginosa, extended-spectrum beta-lactamase-producing Klebsiella species and Escherichia coli, and methicillin-resistant Staphylococcus aureus. The goals of extremity injury care are to prevent infection, promote fracture healing, and restore function. In this review, we use a systematic assessment of military and civilian extremity trauma data to provide evidence-based recommendations for the varying management strategies to care for combat-related extremity injuries to decrease infection rates. We emphasize postinjury antimicrobial therapy, debridement and irrigation, and surgical wound management including addressing ongoing areas of controversy and needed research. In addition, we address adjuvants that are increasingly being examined, including local antimicrobial therapy, flap closure, oxygen therapy, negative pressure wound therapy, and wound effluent characterization. This evidence-based medicine review was produced to support the Guidelines for the Prevention of Infections Associated With Combat-Related Injuries: 2011 Update contained in this supplement of Journal of Trauma.
C1 [Murray, Clinton K.; Hsu, Joseph R.; Ficke, James R.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
   [Hsu, Joseph R.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Obremskey, William T.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
   [Andersen, Romney C.; Whitman, Timothy J.; Fleming, Mark E.] Walter Reed Natl Mil Med Ctr Bethesda, Bethesda, MD USA.
   [Calhoun, Jason H.] Ohio State Univ, Columbus, OH 43210 USA.
   [Clasper, Jon C.] Royal Coll Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
   [Curry, Thomas K.] Madigan Army Med Ctr, Ft Lewis, WA USA.
C3 Brooke Army Medical Center; Vanderbilt University; Walter Reed National
   Military Medical Center; University System of Ohio; Ohio State
   University; Madigan Army Medical Center
RP Murray, CK (通讯作者)，Brooke Army Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM clinton.murray@us.army.mil
RI ; Obremskey, William/HRA-4704-2023; Fleming, Mark/HJA-3208-2022
OI Hospenthal, Duane/0000-0003-3354-8075; Hsu, Joseph/0000-0001-9341-2554;
   Obremskey, William/0000-0002-8942-1842; Fleming,
   Mark/0000-0002-4753-2632; Andersen, Romney/0009-0000-3507-7612
FU US Army Medical Command
FX Financial support for the consensus conference and publication of the
   Journal of Trauma supplement was provided by the US Army Medical
   Command.
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NR 304
TC 114
Z9 144
U1 0
U2 36
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD AUG
PY 2011
VL 71
SU 2
BP S235
EP S257
DI 10.1097/TA.0b013e318227ac5f
PG 23
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 806XB
UT WOS:000293849300004
PM 21814090
DA 2026-07-24
ER
PT J
AU De Feo, M
   Della Corte, A
   Vicchio, M
   Pirozzi, F
   Nappi, G
   Cotrufo, M
AF De Feo, Marisa
   Della Corte, Alessandro
   Vicchio, Mariano
   Pirozzi, Francesco
   Nappi, Gianantonio
   Cotrufo, Maurizio
TI Is Post-Sternotomy Mediastinitis Still Devastating after the Advent of
   Negative-Pressure Wound Therapy?
SO TEXAS HEART INSTITUTE JOURNAL
LA English
DT Article
DE Atmospheric pressure; bacterial infections; cardiac surgical
   procedures/adverse effects; length of stay; mediastinitis/prevention &
   control/therapy; postoperative complications/prevention &
   control/therapy; surgical wound infection/etiology/mortality/prevention
   & control/surgery; survival rate; vacuum curettage/methods; wound
   healing/physiology/therapy
ID VACUUM-ASSISTED CLOSURE; DEEP STERNAL INFECTIONS; OPEN-HEART-SURGERY;
   POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY; MUSCLE FLAPS;
   POSTOPERATIVE MEDIASTINITIS; CONVENTIONAL TREATMENT; SUCTION DRAINAGE;
   MANAGEMENT
AB In this study, we reviewed a 15-year experience with the treatment of a severe sequela of cardiac surgery: post-sternotomy mediastinitis. We compared the outcomes of conventional treatment with those of negative-pressure wound therapy, focusing on mortality rate, sternal reinfection, and length of hospital stay.
   We reviewed data on 157 consecutive patients who were treated at our institution from 1995 through 2010 for post-sternotomy mediastinitis after cardiac surgery Of these patients, 74 had undergone extensive wound debridement followed by negative-pressure wound therapy and 83 had undergone conventional treatment, including primary wound reopening, debridement, closed-chest irrigation without rewiring, topical application of granulated sugar for recurrent cases, and final plastic reconstruction with pectoral muscle flap in most cases.
   The 2 study groups were homogeneous in terms of preoperative data and operative variables (the primary cardiac surgery was predominantly coronary artery bypass grafting). Negative-pressure wound therapy was associated with lower early mortality rates (1.4% vs 3.6%; P=0.35) and significantly lower reinfection rates (1.4% vs 16.9%; P=0.001). Significantly shorter hospital stays were also observed with negative pressure in comparison with conventional treatment (mean durations, 273 +/- 9 vs 30.5 +/- 3 d; P=0.02), consequent to the accelerated process of wound healing with negative-pressure therapy.
   Lower mortality and reinfection rates and shorter hospital stays can result from using negative pressure rather than conventional treatment. Therefore, negative-pressure wound therapy is advisable as first-choice therapy for deep sternal wound infection after cardiac surgery (Tex Heart Inst J 2011;38(4):375-80)
C1 [De Feo, Marisa; Della Corte, Alessandro; Vicchio, Mariano; Pirozzi, Francesco; Nappi, Gianantonio] Univ Naples 2, Dept Cardiothorac Sci, I-80731 Naples, Italy.
   [Cotrufo, Maurizio] Pineta Grande Hosp, Dept Cardiovasc Surg, I-87030 Castelvolturno, CE, Italy.
C3 Universita della Campania Vanvitelli
RP Della Corte, A (通讯作者)，V Monaldi Hosp, Dept Cardiovasc Surg & Transplant, Via L Bianchi, I-80131 Naples, Italy.
EM aledellacorte@libero.it
RI Della Corte, Alessandro/K-9383-2016
OI Della Corte, Alessandro/0000-0002-4636-3339
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NR 30
TC 25
Z9 32
U1 0
U2 1
PU TEXAS HEART INST
PI HOUSTON
PA PO BOX 20345, HOUSTON, TX 77225-0345 USA
SN 1526-6702
J9 TEX HEART I J
JI Tex. Heart Inst. J.
PD AUG
PY 2011
VL 38
IS 4
BP 375
EP 380
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 807CE
UT WOS:000293870300014
PM 21841864
DA 2026-07-24
ER
PT J
AU Sofat, S
   Pope, NH
   David, EA
   Bhanot, P
AF Sofat, Sujata
   Pope, Nicolas H.
   David, Elizabeth A.
   Bhanot, Parag
TI Successful Application of the Vacuum-Assisted Closure System in Delayed
   Primary Closure: A Case of Gastrointestinal Perforation
SO AMERICAN SURGEON
LA English
DT Article
ID WOUND-INFECTION
C1 [Sofat, Sujata; Pope, Nicolas H.; David, Elizabeth A.; Bhanot, Parag] Georgetown Univ Hosp, Washington, DC 20007 USA.
C3 Georgetown University
RP Bhanot, P (通讯作者)，Georgetown Univ Hosp, 3800 Reservoir Rd, Washington, DC 20007 USA.
EM pxb129@gunet.georgetown.edu
CR Astagneau P, 2001, J HOSP INFECT, V48, P267, DOI 10.1053/jhin.2001.1003
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NR 5
TC 0
Z9 0
U1 0
U2 2
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD AUG
PY 2011
VL 77
IS 8
BP E168
EP E169
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 807UP
UT WOS:000293927200041
DA 2026-07-24
ER
PT J
AU Lehner, B
   Fleischmann, W
   Becker, R
   Jukema, GN
AF Lehner, Burkhard
   Fleischmann, Wim
   Becker, Rolf
   Jukema, Gerrolt N.
TI First experiences with negative pressure wound therapy and instillation
   in the treatment of infected orthopaedic implants: a clinical
   observational study
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
ID TOTAL KNEE ARTHROPLASTY; PROSTHETIC JOINT INFECTION; HIP-ARTHROPLASTY;
   DEBRIDEMENT; RETENTION; ANTIBIOTICS; REPLACEMENT
AB Infections associated with orthopaedic implants remain a serious complication. The main objective in acute infection control is component retention, whereas this option is usually not considered for chronic infections.
   This multi-centre prospective, non-randomised observational study investigated one possible treatment option for implant retention in combination with negative pressure wound therapy with instillation (NPWTi). Thirty-two patients with an infected orthopaedic implant were analysed. Twenty-two patients had an acute infection (< 8 weeks after implantation) and ten patients had a chronic infection (> 8 weeks and < 36 weeks after implant placement). Polyhexanide was used as the instillation solution in 31 of the 32 cases.
   Nineteen patients (86.4%) with an acute infection and eight patients (80%) with a chronic infection retained their implant at 4-6 months follow-up after treatment.
   Our study showed that NPWTi can be used as adjunctive therapy for salvage of acutely infected orthopaedic implants and may even be considered for early chronically infected implants.
C1 [Lehner, Burkhard] Orthoped Univ Hosp, Dept Orthoped Oncol & Sept Orthoped Surg, D-69118 Heidelberg, Germany.
   [Fleischmann, Wim] Ludwigsburg Bietigheim Kliniken gGmbH, Dept Trauma & Reconstruct Surg, Bietigheim Bissingen, Germany.
   [Becker, Rolf] Eduarduskrankenhaus, Cologne, Germany.
   [Jukema, Gerrolt N.] Univ Zurich Hosp, Dept Trauma Surg, CH-8091 Zurich, Switzerland.
C3 Ruprecht Karls University Heidelberg; University of Zurich; University
   Zurich Hospital
RP Lehner, B (通讯作者)，Orthoped Univ Hosp, Dept Orthoped Oncol & Sept Orthoped Surg, Schlierbacher Landstr 200A, D-69118 Heidelberg, Germany.
EM burkhard.lehner@med.uni-heidelberg.de
FU Kinetic Concepts, Inc. (San Antonio, TX, USA)
FX This observational study was supported by Kinetic Concepts, Inc. (San
   Antonio, TX, USA). The setup of the study and evaluation of the data
   were performed by the individual members of the Steering Committee.
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NR 28
TC 90
Z9 107
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2695
J9 INT ORTHOP
JI Int. Orthop.
PD SEP
PY 2011
VL 35
IS 9
BP 1415
EP 1420
DI 10.1007/s00264-011-1274-y
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 809OS
UT WOS:000294067200021
PM 21584643
OA Bronze
DA 2026-07-24
ER
PT J
AU Damiani, G
   Pinnarelli, L
   Sommella, L
   Tocco, MP
   Marvulli, M
   Magrini, P
   Ricciardi, W
AF Damiani, G.
   Pinnarelli, L.
   Sommella, L.
   Tocco, M. P.
   Marvulli, M.
   Magrini, P.
   Ricciardi, W.
TI Vacuum-assisted closure therapy for patients with infected sternal
   wounds: A meta-analysis of current evidence
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Vacuum-assisted closure therapy; VAC and traditional therapy; VAC and
   standard moist wound therapy; VAC mortality; VAC length of stay;
   Negative pressure therapy and mortality
ID NOSOCOMIAL INFECTION; SUCTION DRAINAGE; MANAGEMENT; MULTICENTER; IMPACT;
   STAY; COST
AB Acute and chronic wound infections are the main reasons for the observed increase in mortality rate and represent a significant risk factor in hospitalisation. From the patient's perspective, wound therapy is an uncomfortable, painful and long-term treatment. Modern sternal-wound-treatment systems would be expected to shorten wound healing and hospital stay periods.
   Vacuum-assisted closure (VAC) therapy is a system that promotes wound healing through the application of negative pressure by controlled suction to the wound surface. The application of controlled levels of negative pressure accelerates healing in many types of wounds.
   There are a number of scientific publications that have used meta-analysis to compare VAC and traditional therapy, considering changes in wound size. This article surveys the research literature focussing on the management of wound infections.
   The objective of this study is to assess the impact of VAC compared with conventional therapy on length of stay (LOS) and mortality.
   Six articles were selected that included a total of 321 patients (169 for VAC therapy and 152 for conventional therapy).
   The meta-analysis showed that VAC therapy resulted in a decrease of 7.18 days in hospital LOS (confidence interval (CI) 95%: 10.82, 3.54), with no significant impact on mortality.
   Our data provide robust evidence of the effectiveness of VAC therapy. (C) 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Damiani, G.; Marvulli, M.; Ricciardi, W.] Univ Cattolica Sacro Cuore, Dept Publ Hlth, I-00168 Rome, Italy.
   [Pinnarelli, L.; Sommella, L.; Tocco, M. P.; Magrini, P.] San Filippo Neri Hosp Trust, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; San
   Filippo Neri Hospital
RP Damiani, G (通讯作者)，Univ Cattolica Sacro Cuore, Dept Publ Hlth, Largo Francesco Vito 1, I-00168 Rome, Italy.
EM gdamiani@rm.unicatt.it
RI Damiani, Gianfranco/K-2782-2016; Pinnarelli, Luigi/K-5673-2016;
   Ricciardi, Walter/AAB-2056-2019
OI Damiani, Gianfranco/0000-0003-3028-6188; Pinnarelli,
   Luigi/0000-0002-9282-0617; Ricciardi, Walter/0000-0002-5655-688X
CR [Anonymous], REV MAN REVMAN COMP
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NR 24
TC 57
Z9 66
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD SEP
PY 2011
VL 64
IS 9
BP 1119
EP 1123
DI 10.1016/j.bjps.2010.11.022
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 809QU
UT WOS:000294072600008
PM 21256819
DA 2026-07-24
ER
PT J
AU D'Hondt, M
   Devriendt, D
   Van Rooy, F
   Vansteenkiste, F
   D'Hoore, A
   Penninckx, F
   Miserez, M
AF D'Hondt, Mathieu
   Devriendt, Dirk
   Van Rooy, Frank
   Vansteenkiste, Franky
   D'Hoore, Andre
   Penninckx, Freddy
   Miserez, Marc
TI Treatment of small-bowel fistulae in the open abdomen with topical
   negative-pressure therapy
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Open abdomen; Enteroatmospheric fistula; Topical negative pressure
   therapy; VAC therapy
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL-WALL DEFECTS; ENTEROCUTANEOUS
   FISTULAS; MANAGEMENT
AB BACKGROUND: An open abdomen (OA) can result from surgical management of trauma, severe peritonitis, abdominal compartment syndrome, and other abdominal emergencies. Enteroatmospheric fistulae (EAF) occur in 25% of patients with an OA and are associated with high mortality.
   METHODS: We report our experience with topical negative pressure (TNP) therapy in the management of EAF in an OA using the VAC (vacuum asisted closure) device (KCI Medical, San Antonio, TX). Nine patients with 17 EAF in an OA were treated with topical TNP therapy from January 2006 to January 2009. Surgery with enterectomy and abdominal closure was planned 6 to 10 weeks later.
   RESULTS: Three EAF closed spontaneously. The median time from the onset of fistulization to elective surgical management was 51 days. No additional fistulae occurred during VAC therapy. One patient with a short bowel died as a result of persistent leakage after surgery.
   CONCLUSIONS: Although previously considered a contraindication to TNP therapy, EAF can be managed successfully with TNP therapy. Surgical closure of EAFs is possible after several weeks. (C) 2011 Elsevier Inc. All rights reserved.
C1 [D'Hondt, Mathieu; Devriendt, Dirk; Van Rooy, Frank; Vansteenkiste, Franky] Groeninge Hosp, Dept Digest Surg, B-8500 Kortrijk, Belgium.
   [D'Hondt, Mathieu; D'Hoore, Andre; Penninckx, Freddy; Miserez, Marc] Univ Hosp Leuven, Dept Digest Surg, B-3000 Louvain, Belgium.
C3 KU Leuven; University Hospital Leuven
RP D'Hondt, M (通讯作者)，Groeninge Hosp, Dept Digest Surg, President Kennedylaan 4, B-8500 Kortrijk, Belgium.
EM mathieudhondt2000@yahoo.com
OI , marc/0000-0002-7047-6114
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NR 22
TC 58
Z9 65
U1 0
U2 9
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD AUG
PY 2011
VL 202
IS 2
BP E20
EP E24
DI 10.1016/j.amjsurg.2010.06.025
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 811LW
UT WOS:000294213300003
PM 21601824
DA 2026-07-24
ER
PT J
AU Strowitzki, M
   Vastmans, J
   Vogel, M
   Jaksche, H
AF Strowitzki, Martin
   Vastmans, Jan
   Vogel, Matthias
   Jaksche, Hans
TI Complex 360°-reconstruction and stabilization of the cervical spine due
   to osteomyelitis
SO EUROPEAN SPINE JOURNAL
LA English
DT Article
DE Vertebral osteomyelitis; Spondylodiscitis; Cervical reconstruction
ID SURGICAL-MANAGEMENT; SPONDYLODISCITIS; ANTERIOR; FUSION;
   INSTRUMENTATION; DEBRIDEMENT; FIXATION; CAGES
AB Osteomyelitis of the cervical spine may lead to profound bony destruction. The presented case developed multilevel osteomyelitic destruction of the cervical spine after decompression due to cervical myelopathy. He could be cured by a multiple-stage procedure: step one: debridement and removal of all anterior implants with vacuum-assisted closure combined with dorsal instrumentation from C0 to T3; step two: anterior reconstruction with expandable titanium cages and plate. The patient regained walking with the aid of a walking frame. The following recommendations are given: multiple stage procedure, extensive debridement and stabilization via an anterior and posterior approach, use of titanium implants.
C1 [Strowitzki, Martin; Jaksche, Hans] Trauma Ctr Murnau, Dept Neurosurg, D-82418 Murnau, Germany.
   [Vastmans, Jan; Vogel, Matthias] Trauma Ctr Murnau, Dept Spinal Cord Injuries, D-82418 Murnau, Germany.
RP Strowitzki, M (通讯作者)，Trauma Ctr Murnau, Dept Neurosurg, Prof Kuntscher Str 8, D-82418 Murnau, Germany.
EM martin.strowitzki@bgu-murnau.de
CR ACOSTA FJR, 2004, FOCUS, V17, pE2
   Barnes Bryan, 2004, Neurosurg Focus, V17, pE11
   Bose B, 1998, SURG NEUROL, V49, P25, DOI 10.1016/S0090-3019(97)00306-6
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   Lee Max C, 2004, Neurosurg Focus, V17, pE7
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NR 28
TC 6
Z9 7
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0940-6719
EI 1432-0932
J9 EUR SPINE J
JI Eur. Spine J.
PD JUL
PY 2011
VL 20
SU 2
BP S248
EP S252
DI 10.1007/s00586-010-1645-x
PG 5
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 811OM
UT WOS:000294221200025
PM 21116660
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Petkar, KS
   Dhanraj, P
   Kingsly, PM
   Sreekar, H
   Lakshmanarao, A
   Lamba, S
   Shetty, R
   Zachariah, JR
AF Petkar, Kiran S.
   Dhanraj, Prema
   Kingsly, Paul M.
   Sreekar, H.
   Lakshmanarao, Aravind
   Lamba, Shashank
   Shetty, Rahul
   Zachariah, Jewel Raj
TI A prospective randomized controlled trial comparing negative pressure
   dressing and conventional dressing methods on split-thickness skin
   grafts in burned patients
SO BURNS
LA English
DT Article
DE Negative pressure dressings; Vacuum assisted closure; Skin graft
ID VACUUM-ASSISTED CLOSURE; DONOR SITE; BOLSTER; WOUNDS
AB Introduction: Split-thickness skin grafting (SSG) is a technique used extensively in the care of burn patients and is fraught with suboptimal graft take when there is a less-than-ideal graft bed and/or grafting conditions. The technique of Negative Pressure Dressing (NPD), initially used for better wound healing has been tried on skin-grafts and has shown to increase the graft take rates. However, comparative studies between the conventional dressing and vacuum assisted closure on skin grafts in burn patients are unavailable. The present study was undertaken to find out if NPD improves graft take as compared to conventional dressing in burns patients.
   Materials and methods: Consecutive burn patients undergoing split-skin grafting were randomized to receive either a conventional dressing consisting of Vaseline gauze and cotton pads or to have a NPD of 80 mm Hg for four days over the freshly laid SSG. The results in terms of amount of graft take, duration of dressings for the grafted area and the cost of treatment of wound were compared between the two groups.
   Results: A total of 40 split-skin grafts were put on 30 patients. The grafted wounds included acute and chronic burns wounds and surgically created raw areas during burn reconstruction. Twenty-one of them received NPD and 19 served as controls. Patient profiles and average size of the grafts were comparable between the two groups. The vacuum closure assembly was well tolerated by all patients. Final graft take at nine days in the study group ranged from 90 to 100 per cent with an average of 96.7 per cent (SD: 3.55). The control group showed a graft take ranging between 70 and 100 percent with an average graft take of 87.5 percent (SD: 8.73). Mean duration of continued dressings on the grafted area was 8 days in cases (SD: 1.48) and 11 days in controls (SD: 2.2) after surgery. Each of these differences was found to be statistically significant (p < .0.001).
   Conclusion: Negative pressure dressing improves graft take in burns patients and can particularly be considered when wound bed and grafting conditions seem less-than-ideal. The negative pressure can also be effectively assembled using locally available materials thus significantly reducing the cost of treatment. (C) 2011 Elsevier Ltd and ISBI. All rights reserved.
C1 [Petkar, Kiran S.; Dhanraj, Prema; Kingsly, Paul M.; Sreekar, H.; Lakshmanarao, Aravind; Lamba, Shashank; Shetty, Rahul; Zachariah, Jewel Raj] Christian Med Coll & Hosp, Dept Plast Surg, Vellore 632004, Tamil Nadu, India.
C3 Christian Medical College & Hospital (CMCH) Vellore
RP Petkar, KS (通讯作者)，Christian Med Coll & Hosp, Dept Plast Surg, Vellore 632004, Tamil Nadu, India.
EM drkiranpetkar2009@gmail.com
RI ; Doss, Kingsly/AAM-9639-2020
OI Petkar, Kiran/0000-0002-3129-4529; Sreekar,
   Harinatha/0000-0001-5364-1475
CR Andrews BT, 2006, LARYNGOSCOPE, V116, P1918, DOI 10.1097/01.mlg.0000235935.07261.98
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Brandi C, 2008, J PLAST RECONSTR AES, V61, P1507, DOI 10.1016/j.bjps.2007.09.036
   Fleischmann W, 1996, UNFALLCHIRURG, V99, P283
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   THORNE CH, 2007, GRABB SMITHS PLASTIC, P8
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
NR 11
TC 96
Z9 112
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD SEP
PY 2011
VL 37
IS 6
BP 925
EP 929
DI 10.1016/j.burns.2011.05.013
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 815GA
UT WOS:000294512900002
PM 21723044
DA 2026-07-24
ER
PT J
AU Trujillo-Martín, M
   García-Pérez, L
   Serrano-Aguilar, P
AF Trujillo-Martin, Maria
   Garcia-Perez, Lidia
   Serrano-Aguilar, Pedro
TI Effectiveness, safety and cost-effectiveness of the negative pressure
   wound therapy on the treatment of chronic wounds: a systematic review
SO MEDICINA CLINICA
LA Spanish
DT Review
DE Negative-pressure wound therapy; Vacuum-assisted closure; Wounds; Ulcer;
   Review
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   ULCERS; GUIDELINES; MANAGEMENT; DRESSINGS; SCIENCE
AB Negative-pressure wound therapy (NPWT) is used to promote wound healing by using suction to drain excess fluid from wounds. A systematic literature review was undertaken to assess the effectiveness, safety and cost-effectiveness of NPWT for the treatment of chronic wounds. Medline, Embase, CENTRAL, CINAHL and the Cochrane Wounds Group Specialised Trials Register were searched. A total of 9 randomized controlled trials (n = 568) comparing NPWT with conventional wound therapy and four economic evaluations identified through NHS EED database were included. Five trials showed significant differences in favour of NPWT in primary outcome measures; however, most studies had small sample sizes and low scientific validity. Complications and adverse effects of NPWT are scarce compared to those of conventional treatment. There is no conclusive scientific evidence on the effectiveness and cost-effectiveness of NPWT in the treatment of chronic wounds and therefore its widespread use is not justified. (C) 2010 Elsevier Espana, S.L. All rights reserved.
C1 [Trujillo-Martin, Maria; Garcia-Perez, Lidia] Fdn Canaria Invest & Salud FUNCIS, Santa Cruz De Tenerife, Spain.
   [Trujillo-Martin, Maria; Garcia-Perez, Lidia; Serrano-Aguilar, Pedro] CIBER Epidemiol & Salud Publ CIBERESP, Sao Paulo, Brazil.
   [Serrano-Aguilar, Pedro] Serv Canario Salud, Serv Evaluac & Planificac, Santa Cruz De Tenerife, Spain.
RP Trujillo-Martín, M (通讯作者)，Fdn Canaria Invest & Salud FUNCIS, Santa Cruz De Tenerife, Spain.
EM mar.trujillomartin@sescs.es
RI García-Pérez, Lidia/C-6364-2011
OI García-Pérez, Lidia/0000-0002-5626-8116
CR Akbari A, 2007, J REHABIL RES DEV, V44, P631, DOI 10.1682/JRRD.2007.01.0002
   Andreassen GS, 2006, ACTA ORTHOP, V77, P820, DOI 10.1080/17453670610013051
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
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   Flack S, 2008, J Wound Care, V17, P71
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
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   Meyer DC, 2005, PLAST RECONSTR SURG, V115, P2174, DOI 10.1097/01.PRS.0000165495.54252.84
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NR 26
TC 10
Z9 17
U1 0
U2 24
PU ELSEVIER DOYMA SL
PI BARCELONA
PA TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN
SN 0025-7753
EI 1578-8989
J9 MED CLIN-BARCELONA
JI Med. Clin.
PD SEP 17
PY 2011
VL 137
IS 7
BP 321
EP 328
DI 10.1016/j.medcli.2010.06.010
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 817GH
UT WOS:000294658800008
PM 20889170
DA 2026-07-24
ER
PT J
AU Verdam, FJ
   Dolmans, DEJGJ
   Loos, MJ
   Raber, MH
   de Wit, RJ
   Charbon, JA
   Vroemen, JPAM
AF Verdam, Froukje J.
   Dolmans, Dennis E. J. G. J.
   Loos, Maarten J.
   Raber, Menno H.
   de Wit, Ralph J.
   Charbon, Jan A.
   Vroemen, Jos P. A. M.
TI Delayed Primary Closure of the Septic Open Abdomen with a Dynamic
   Closure System
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; GENERAL-SURGERY; WALL DEFECTS;
   MANAGEMENT; TRAUMA; STRATEGY
AB Background The major challenge in the management of patients with an infected open abdomen (OA) is to control septic peritonitis and intra-abdominal fluid secretion, and to facilitate repeated abdominal exploration, while preserving the fascia for delayed primary closure. We here present a novel method for closure of the infected OA, based on continuous dynamic tension, in order to achieve re-approximation of the fascial edges of the abdominal wall.
   Methods Eighteen cases with severe peritonitis of various origin (e.g., gastrointestinal perforations, anastomotic leakage) were primarily stabilized by laparostomy, sealed with either the vacuum-assisted closure abdominal dressing or the Bogota bag. After hemodynamic stabilization and control of the sepsis, the Abdominal Re-approximation Anchor System (ABRA; Canica Design, Almonte, Ontario, Canada) was applied. This system approximates the wound margins through dynamic traction exerted by transfascial elastomers. Before ABRA application, 5/18 patients had a grade 2B, 2/18 a grade 3, and 11/18 a grade or 4 status according to the open abdomen classification of Bjorck.
   Results In this severely ill population the mean time before ABRA system application was 12 days (range: 2-39 days). Two of 18 patients died of non-ABRA-related causes within three weeks. In 14 of the remaining 16 patients (88%) primary abdominal closure of the midline was accomplished in 15 days (range: 7-30 days). The other two patients needed a component separation technique according to Ramirez to reach closure. However, secondary wound dehiscence occurred in both these patients. Two thirds of patients (12/18) developed pressure sores to the skin and/or dermis, but all healed without further complications. During outpatient clinic follow-up, 4/14 successfully closed patients still developed a midline hernia.
   Conclusions Delayed primary closure of OA in septic patients could be achieved in 88% with this new approximation system. However, the risk of hernia development remained. We consider this system a useful tool in the treatment of septic patients with an open abdomen.
C1 [Verdam, Froukje J.; Dolmans, Dennis E. J. G. J.; Vroemen, Jos P. A. M.] Amphia Hosp, Dept Gen Surg, NL-4800 RK Breda, Netherlands.
   [Verdam, Froukje J.] Maastricht Univ, Med Ctr, Dept Gen Surg, Maastricht, Netherlands.
   [Dolmans, Dennis E. J. G. J.] Atrium Med Ctr, Dept Gen Surg, Heerlen, Netherlands.
   [Loos, Maarten J.; Charbon, Jan A.] Maxima Med Ctr, Dept Gen Surg, Veldhoven, Netherlands.
   [Raber, Menno H.; de Wit, Ralph J.] Med Spectrum Twente, Dept Gen Surg, Enschede, Netherlands.
C3 Amphia Hospital; Maastricht University; Atrium Medical Center; Maxima
   Medical Center; Medical Spectrum Twente
RP Verdam, FJ (通讯作者)，Amphia Hosp, Dept Gen Surg, POB 90158, NL-4800 RK Breda, Netherlands.
EM froukjeverdam@yahoo.com; jvroemen@amphia.nl
OI Verdam, Froukje/0000-0002-3986-5250
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   Schecter WP, 2006, J AM COLL SURGEONS, V203, P390, DOI 10.1016/j.jamcollsurg.2006.06.001
   Tsuei BJ, 2004, AM SURGEON, V70, P652
   Urbaniak RM, 2006, ANN PLAS SURG, V57, P573, DOI 10.1097/01.sap.0000237052.11796.63
   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
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   Wondberg D, 2008, WORLD J SURG, V32, P2724, DOI 10.1007/s00268-008-9762-y
NR 25
TC 69
Z9 78
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD OCT
PY 2011
VL 35
IS 10
BP 2348
EP 2355
DI 10.1007/s00268-011-1210-8
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 819EI
UT WOS:000294807800023
PM 21850603
OA hybrid
DA 2026-07-24
ER
PT J
AU Chen, E
   Friedman, HI
AF Chen, Elliott
   Friedman, Harold I.
TI Management of Regional Hidradenitis Suppurativa With Vacuum-Assisted
   Closure and Split Thickness Skin Grafts
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE hidradenitis suppurativa; vacuum-assisted closure; split thickness skin
   grafts
ID NEGATIVE-PRESSURE DRESSINGS; PATHOGENESIS; APOCRINE; THERAPY;
   CLINDAMYCIN; EFFICACY; EXCISION; TRIAL
AB Background: Hidradenitis suppurativa can be a debilitating chronic illness. The underlying cause of the disease is still not clear, but effective treatment of widespread regional disease relies on resection of all the involved skin and subcutaneous tissue. Closure of the resulting large wound is dependent on either flap or skin graft coverage. Many of the resulting wounds are too large for flap closure or result in unacceptable flap donor site deficits.
   Methods: We present a series of 11 patients with 24 regional disease sites treated with a protocol of excision, followed by wound vacuum-assisted closure (VAC; KCI, San Antonio, TX) therapy to stimulate angiogenesis of exposed fat, and then skin grafting with the use of VAC to support the grafts on the recipient sites.
   Results: Only 3 of the patients required regrafting. One patient had a VAC failure because of poor patient compliance, and 1 patient had 4 sites that each required regrafting as the epithelium would not fill in the residual open areas as it usually did in other patients. All patients were cured of their local disease.
   Conclusions: Massive regional hidradenitis suppurativa can be successfully managed with wide excision, VAC therapy, and skin grafting to allow these patients to live normal and productive lives.
C1 [Chen, Elliott; Friedman, Harold I.] Univ S Carolina, Div Plast Surg, Dept Surg, Sch Med, Columbia, SC 29203 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia
RP Friedman, HI (通讯作者)，Univ S Carolina, Div Plast Surg, Dept Surg, Sch Med, Suite 302,2 Med Pk Rd, Columbia, SC 29203 USA.
EM harold.friedman@uscmed.sc.edu
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NR 41
TC 54
Z9 57
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2011
VL 67
IS 4
BP 397
EP 401
DI 10.1097/SAP.0b013e3181f77bd6
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 821BC
UT WOS:000294948800018
PM 21587057
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Malmsjö, M
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Ingemansson, Richard
TI Effects on drainage of the mediastinum and pleura during negative
   pressure wound therapy when using a rigid barrier to prevent heart
   rupture
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Drainage; Experimental; Negative wound pressure therapy; Post sternotomi
   mediastinitis; Wound closure
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; POSTSTERNOTOMY
   MEDIASTINITIS; CARDIAC-SURGERY; INFECTION
AB Right ventricular heart rupture is a devastating complication associated with negative pressure wound therapy (NPWT) following cardiac surgery. The use of a rigid disc has been suggested to offer protection against this lethal complication by preventing the heart from being drawn up towards, and damaged by, the sharp sternum edges. The aim of the present study was to compare the wound fluid evacuation from the pericardium and the left pleura when using NPWT with such a disc between the sternal edges and the heart, and when using conventional NPWT. Six pigs underwent median sternotomy followed by NPWT at - 120 mmHg, using foam, with or without a rigid plastic disc between the heart and the sternal edges. A 250 ml saline was infused into the pericardium, and the time required for fluid evacuation was measured. A 500 ml saline was infused into the left pleura and the time for fluid evacuation measured. The pericardium was effectively drained of 250 ml fluid in both cases [conventional NPWT: 24 +/- 0.7 seconds, NPWT with the disc: 25 +/- 1.1 seconds (n.s.)]. The left pleura was effectively drained when using NPWT with the disc, but was not drained at all when using conventional NPWT. The left pleura could be effectively drained of 500 ml fluid when a rigid perforated plastic disc was inserted between the sternal edges and the heart during NPWT. Significantly less drainage of the left pleura was possible when using conventional NPWT without the disc. The pericardium was equally good drained using NPWT with or without the disc.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   [Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   Braxton JH, 2000, ANN THORAC SURG, V70, P2004, DOI 10.1016/S0003-4975(00)01814-2
   Braxton John H, 2004, Semin Thorac Cardiovasc Surg, V16, P70
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   Fleck Tatjana, 2006, Int Wound J, V3, P273, DOI 10.1111/j.1742-481X.2006.00273.x
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Khoynezhad A, 2004, J CARDIAC SURG, V19, P74, DOI 10.1111/j.0886-0440.2004.04015.x
   Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   Malmsjö M, 2009, J THORAC CARDIOV SUR, V138, P712, DOI 10.1016/j.jtcvs.2008.11.068
   Petzina R, 2007, J THORAC CARDIOV SUR, V133, P1154, DOI 10.1016/j.jtcvs.2007.01.011
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
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   Sjogren Johan, 2004, Interact Cardiovasc Thorac Surg, V3, P666, DOI 10.1016/j.icvts.2004.08.003
NR 15
TC 4
Z9 4
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2011
VL 8
IS 5
BP 454
EP 458
DI 10.1111/j.1742-481X.2011.00816.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 822EG
UT WOS:000295026100004
PM 21692991
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Fraccalvieri, M
   Ruka, E
   Bocchiotti, MA
   Zingarelli, E
   Bruschi, S
AF Fraccalvieri, Marco
   Ruka, Erind
   Bocchiotti, Maria Alessandra
   Zingarelli, Enrico
   Bruschi, Stefano
TI Patient's pain feedback using negative pressure wound therapy with foam
   and gauze
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Foam; Gauze; Negative pressure wound therapy; NPWT; Pain
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; EXPERIENCE; STATE;
   ART
AB Wounds can be caused by different mechanisms and have a significant morbidity and mortality. Negative pressure wound therapy (NPWT) is one of the most successful treatment modalities for wound healing. We have been using both foam and gauze-based NPWT. During application of NPWT, we noticed that the patient's pain was of varying intensity depending on the filler used. The aim of our work was to compare the level of pain and feedback before, during the treatment and at the dressing change after treatment with NPWT with two different fillers. For this study, we compared a pool of 13 gauze-treated patients with a pool of 18 foam-treated patients regarding the level of pain and feedback before, during the treatment and at the dressing change after treatment with NPWT. They were all post-traumatic patients with loss of tissue up to the muscular band. The patients were asked to respond to a questionnaire interviewed by the same physician to assess the level of pain using VNS (verbal numerical scale). We observed similar difference of means before and during the treatment with NPWT with gauze and foam. Regarding the pain at the dressing change, the mean of the scores for the foam was 6.5 while for the gauze was 4.15. In this case, we noticed the most significant difference between means from the scores given: 2.35 which was a statistically significant difference between the two groups (P = 0.046). The finding of this study confirms less pain at the dressing change after treatment with gauze-based NPWT. In our opinion, this finding is related to the more adhesive property of the foam probably because of the ingrowth of the granulation tissue in the micropores present on the foam. Considering this statement, we recommend the foam for neuropathic and paraplegic patients and the gauze for patients with bone and tendon exposition wounds, patients that do not tolerate NPWT with foam and low compliant patient particularly paediatric and old-age patients. We remind that the performance of this study was not sponsored by any company.
C1 [Fraccalvieri, Marco; Ruka, Erind; Bocchiotti, Maria Alessandra; Zingarelli, Enrico; Bruschi, Stefano] Univ Turin, Dept Reconstruct & Aesthet Plast Surg, San Giovanni Battista Hosp, Turin, Italy.
C3 University of Turin; A.O.U. Citta della Salute e della Scienza di
   Torino; AOU San Giovanni Battista-Molinette
RP Fraccalvieri, M (通讯作者)，Univ Turin, Dept Reconstruct & Aesthet Plast Surg, San Giovanni Battista Hosp, Turin, Italy.
EM marco@fraccalvieri.it
RI /AAF-4387-2019
OI Bruschi, Stefano/0000-0002-4746-9864; Bocchiotti, Maria
   Alessana/0000-0003-0723-1074
CR Akça O, 1999, LANCET, V354, P41, DOI 10.1016/S0140-6736(99)00874-0
   Apostoli Alberto, 2008, Prof Inferm, V61, P158
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Borgquist O, 2009, WOUNDS, V21, P302
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NR 19
TC 35
Z9 41
U1 0
U2 12
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2011
VL 8
IS 5
BP 492
EP 499
DI 10.1111/j.1742-481X.2011.00821.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 822EG
UT WOS:000295026100009
PM 21827628
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Fuller, M
   Luff, R
   Van den Boom, M
AF Fuller, Matthew
   Luff, Robin
   Van den Boom, Monique
TI A novel approach to wound management and prosthetic use with concurrent
   vacuum-assisted closure therapy
SO PROSTHETICS AND ORTHOTICS INTERNATIONAL
LA English
DT Article
DE Prosthetic design; rehabilitation of amputees; wound management
ID AMPUTATION; AMPUTEES
AB Background and Aim: Stump healing is critical to post amputation management. When healing is not optimal, immobility is prolonged and patients risk hospital acquired deconditioning. Two clinical cases with unhealed trans-femoral stump wounds are described. Vacuum assisted closure (VAC) dressing with concurrent prosthetic utilisation was undertaken successfully in both cases.
   Technique: Fitting of the prosthetic socket included space for VAC dressing with modifications to allow the suction piping to exit the prosthesis. With VAC application, timely rehabilitation and mobility was enabled despite incomplete wound healing.
   Discussion: The two clinical cases described made excellent progress. Discharge home was expedited with the provision of portable VAC pumps. Wounds healed fully without infection. Both patients were able to mobilise sooner than if they had to wait for complete wound closure and, importantly, the consequences of prolonged immobility were minimised. No extra costs were incurred using this novel therapy.
C1 [Fuller, Matthew] Bowley Close Rehabil Ctr, Prosthet Physiotherapy Dept, Southwark PCT, London, England.
   [Van den Boom, Monique] Southwark PCT Rehabil Ctr, Prosthet Dept, London, England.
RP Fuller, M (通讯作者)，Guys & St Thomas NHS Fdn Trust, Physiothatrpy Dept, St Thomas Hosp, Westminster Bridge Rd, London SE1 7EH, England.
EM matthew.fuller@gstt.nhs.uk
CR Asano M, 2008, PROSTHET ORTHOT INT, V32, P231, DOI 10.1080/03093640802024955
   de Morton NA, 2007, CLIN REHABIL, V21, P3, DOI 10.1177/0269215506071313
   Harker J., 2006, World Wide Wounds
   Kulkarni J, 2006, Int J Surg, V4, P217
   MIKLOS C, 2007, TECH FOOT ANKLE SURG, V6, P166
   Nawijn SE, 2005, PROSTHET ORTHOT INT, V29, P13, DOI 10.1080/17461550500066832
   Ryall NH, 2003, DISABIL REHABIL, V25, P833, DOI 10.1080/0963828021000056460
   Thomas Steve., 2001, World Wide Wounds
   van Velzen AD, 2005, PROSTHET ORTHOT INT, V29, P3, DOI 10.1080/17461550500069588
   VanRoss ER, 2009, ARCH PHYS MED REHAB, V90, P610, DOI 10.1016/j.apmr.2008.10.026
NR 10
TC 1
Z9 1
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0309-3646
EI 1746-1553
J9 PROSTHET ORTHOT INT
JI Prosthet. Orthot. Int.
PD JUN
PY 2011
VL 35
IS 2
BP 246
EP 249
DI 10.1177/0309364610397085
PG 4
WC Orthopedics; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rehabilitation
GA 822GV
UT WOS:000295032900015
PM 21527397
DA 2026-07-24
ER
PT J
AU Kilpadi, DV
   Cunningham, MR
AF Kilpadi, Deepak V.
   Cunningham, Mark R.
TI Evaluation of closed incision management with negative pressure wound
   therapy (CIM): Hematoma/seroma and involvement of the lymphatic system
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISIONS
AB The objective of this porcine study was to evaluate the effect of closed incision management with negative pressure wound therapy (CIM) on hematoma/seroma formation, fluid removal into the CIM canister, and involvement of the lymphatic system. In each swine (n = 8), two sets of ventral contralateral subcutaneous dead spaces with overlying sutured incisions were created. Stable isotope-labeled nanospheres were introduced into each subcutaneous dead space. Each contralateral incision was assigned to CIM (continuous -125 mmHg negative pressure) and control (semipermeable film dressing), respectively. Following 4 days of therapy, hematoma/seroma was weighed, total fluid volume in canisters was measured, five pre-identified lymph nodes were harvested, and five key organs were biopsied. There was 25 +/- 8 g (standard error [SE]) (63%) less hematoma/seroma in CIM sites compared to control sites (p = 0.002), without any fluid collection in the CIM canister. In lymph nodes, there were similar to 60 mu g (similar to 50%) more 30- and 50-nm nanospheres from CIM sites than from control sites (p = 0.04 and 0.05, respectively). There was significantly greater nanosphere incidence from CIM sites than from control sites in lungs, liver, and spleen (p < 0.05); no nanospheres were detected in kidney biopsies. Thus, in this porcine model, application of CIM significantly decreased hematoma/seroma levels without fluid collection in the canister, which may be explained by increased lymph clearance.
C1 [Kilpadi, Deepak V.] KCI, San Antonio, TX USA.
   [Cunningham, Mark R.] Surpass Inc, Osceola, WI USA.
RP Kilpadi, DV (通讯作者)，6203 Farinon Dr, San Antonio, TX 78249 USA.
EM kilpadid@kci1.com
CR Abbas SM, 2009, ANZ J SURG, V79, P247, DOI 10.1111/j.1445-2197.2009.04854.x
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   Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
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   Easterlin B, 2007, WOUNDS, V19, P331
   GNEPP DR, 1984, EDEMA, P263
   Gomoll AH, 2006, J ORTHOP TRAUMA, V20, P705, DOI 10.1097/01.bot.0000211159.98239.d2
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   Holm C, 1998, EUR J SURG, V164, P179
   Kilpadi DV, 2007, ANN PLAS SURG, V58, P555, DOI 10.1097/01.sap.0000244991.90285.c3
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Murphey GC, 2009, WOUND REPAIR REGEN, V17, P113, DOI 10.1111/j.1524-475X.2008.00448.x
   Reinhardt CP, 2001, AM J PHYSIOL-HEART C, V280, pH108, DOI 10.1152/ajpheart.2001.280.1.H108
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   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
   Stannard JR, 2009, OSTOMY WOUND MANAG, V55, P58
   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   WILKES RP, SURG INNOV IN PRESS
   Wilson Joyce A, 2004, Adv Skin Wound Care, V17, P426, DOI 10.1097/00129334-200410000-00013
   YASZAY B, 2010, P 2010 SAWC WHS APR, pS128
NR 23
TC 157
Z9 179
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP-OCT
PY 2011
VL 19
IS 5
BP 588
EP 596
DI 10.1111/j.1524-475X.2011.00714.x
PG 9
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 823AA
UT WOS:000295091700009
PM 22092797
DA 2026-07-24
ER
PT J
AU Chong, SJ
   Tan, MK
   Liang, WH
   Kim, SJ
   Soh, CR
AF Chong, Si Jack
   Tan, Meng Kwan
   Liang, Weihao
   Kim, Soo Joang
   Soh, Chai Rick
TI Maintenance of negative-pressure wound therapy while undergoing
   hyperbaric oxygen therapy
SO DIVING AND HYPERBARIC MEDICINE
LA English
DT Article
DE Wounds; hyperbaric oxygen; treatment; equipment; safety
AB (Chong SI, Tan MK, Liang W, Kim SJ, Soh CR. Maintenance of negative-pressure wound therapy while undergoing hyperbaric oxygen therapy. Diving Hyperb Med. 2011;41(3):147-50.)
   Background: Both negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBOT) are useful modalities in the treatment of problem wounds. However, none of the commercially available portable negative-pressure devices have been certified safe for use in a recompression chamber. Thus, the NPWT device is removed while the patient undergoes HBOT. The purpose of this study is to demonstrate that wound negative pressure can be effectively and safely maintained during HBOT.
   Patients and methods: In a small, prospective, randomised crossover trial, we used commonly available clinical materials to connect the NPWT suction tubing to the negative suction generating device in the hyperbaric chamber. Six patients each underwent one HBOT session with continuous NPWT and one HBOT session without concurrent NPWT. We assessed the patient's pain score, the amount of exudate aspirated by the NPWT during HBOT, and the appearance of the wound dressing after each session was assessed in a blinded manner.
   Results: There were no differences in pain scores between the two HBOT sessions. The amount of exudate aspirated during HBOT with NPWT ranged from 5 to 12 ml. Five of the six patients has a better appearance scoring of their dressing when NPWT was maintained during HBOT (P = 0.006).
   Conclusion: We successfully demonstrated a simple design that allows the maintenance of NPWT during HBOT without causing additional pain, and with continued extraction of exudate. The maintenance of NPWT during HBOT also allowed the dressing to be maintained undisturbed.
C1 [Chong, Si Jack] Republ Singapore Navy, Navy Med Serv, Singapore 498822, Singapore.
   [Chong, Si Jack; Liang, Weihao] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 0316, Singapore.
   [Tan, Meng Kwan; Kim, Soo Joang] Singapore Gen Hosp, Hyperbar & Diving Med Ctr, Singapore 0316, Singapore.
   [Soh, Chai Rick] Singapore Gen Hosp, Dept Anaesthesiol, Singapore 0316, Singapore.
C3 Singapore General Hospital; Singapore General Hospital; Singapore
   General Hospital
RP Chong, SJ (通讯作者)，Republ Singapore Navy, Navy Med Serv, 126 Tanah Merah Coast Rd, Singapore 498822, Singapore.
EM chong_si_jack@hotmail.com
CR [Anonymous], 2008, HYP OX THER IND
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Clark L A, 1999, Respir Care Clin N Am, V5, P203
   FABIAN TS, 2007, WOUNDS, V19, P120
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NR 9
TC 6
Z9 9
U1 0
U2 10
PU SOUTH PACIFIC UNDERWATER MED SOC
PI MELBOURNE
PA C/O AUSTRALIAN & NEW ZEALAND COLL ANAESTHETISTS, 630 ST KILDA RD,
   MELBOURNE, VIC 3004, AUSTRALIA
SN 1833-3516
J9 DIVING HYPERB MED
JI Diving Hyperb. Med.
PD SEP
PY 2011
VL 41
IS 3
BP 147
EP 150
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 825GF
UT WOS:000295258500009
PM 21948500
DA 2026-07-24
ER
PT J
AU Dini, V
   Miteva, M
   Romanelli, P
   Bertone, M
   Romanelli, M
AF Dini, Valentina
   Miteva, Maria
   Romanelli, Paolo
   Bertone, Mariastefania
   Romanelli, Marco
TI Immunohistochemical Evaluation of Venous Leg Ulcers Before and After
   Negative Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; IMMUNOREACTIVITY; PATHOGENESIS; MECHANISMS;
   EXPRESSION; OXYGEN; D2-40
AB Venous leg ulcers represent a medical challenge. Whenever possible, therapy should be causal and include compression therapy and surgery. Negative pressure wound therapy (NPWT) has been successfully used in several phases of venous leg ulcer treatment. Positive effects of NPWT, such as reduction of edema, drainage of wound exudate, and acceleration of granulation tissue formation, are reasons for recommending NPWT in order to improve healing rates. Aim. The main goal of this study was to evaluate, using immunohistochemical markers, the efficacy of NPWT in terms of neoangiogenesis and granulation tissue promotion in the treatment of hard-to-heal venous leg ulcers. Methods. Thirty patients with hard-to-heal venous leg ulcers were included. The patients were divided into two groups: one group treated with NPWT, polyurethane foam, and four-layer bandaging system, and the second group with moist wound dressings and four-layer bandaging system. Patients were monitored before and after 1 week of treatment with multiple biopsies taken from the wound bed and wound edge. Immunohistochemical evaluation included markers for angiogenesis (CD31), lymphatic vessels (D240), macrophages (CD68), and lymphocytes (CD3). Results. All patients included in the NPWT group, after 1 week, showed a significant improvement in terms of angiogenesis, lymphatic vessels, and macrophage and lymphocyte proliferation, compared to the control group. Conclusion. This study objectively demonstrated the efficacy of NPWT in hard-to-heal venous leg ulcers via immunohistochemical findings. In particular, the results showed rapid granulation and neoangiogenesis promotion. In the authors' opinion, NPWT must be included as an adjuvant to standard venous leg ulcer therapy.
C1 [Dini, Valentina; Bertone, Mariastefania; Romanelli, Marco] Univ Pisa, Dept Dermatol, I-56126 Pisa, Italy.
   [Miteva, Maria; Romanelli, Paolo] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
C3 University of Pisa; University of Miami
RP Romanelli, M (通讯作者)，Univ Pisa, Dept Dermatol, Via Roma 67, I-56126 Pisa, Italy.
EM m.romanelli@med.unipi.it
RI dini, valentina/F-7747-2017; romanelli, marco/ABI-1154-2020
OI dini, valentina/0000-0002-8537-1999; romanelli,
   marco/0000-0002-4127-0141
FU KCI International; SAWC Spring Young Investigator's Award
FX This study was supported by an unrestricted educational grant from KCI
   International. This research was based on Dr. Dini's abstract, which won
   the 2010 SAWC Spring Young Investigator's Award.
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NR 29
TC 6
Z9 8
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2011
VL 23
IS 9
BP 257
EP 266
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 826IY
UT WOS:000295349000005
PM 25879266
DA 2026-07-24
ER
PT J
AU Impellizzeri, P
   Dardik, H
   Shah, HJ
   Brotman-O'Neil, A
   Ibrahim, IM
AF Impellizzeri, Paul
   Dardik, Herbert
   Shah, Hemal J.
   Brotman-O'Neil, Alissa
   Ibrahim, Ibrahim M.
TI Vacuum-assisted closure therapy with omental transposition for salvage
   of infected prosthetic femoral-distal bypass involving the femoral
   anastomosis
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID RECONSTRUCTION; PROTECTION; MANAGEMENT
AB Vascular graft infections are associated with the potential for devastating sequelae, including hemorrhage, septicemia, amputation, and death. Graft excision and debridement of the infected bed with revascularization via an extra-anatomic site or orthotopic vein bypass has been the traditional treatment of choice. Because the morbidity of these operations is substantial, less radical graft preservation techniques are desirable, such as myoplasty, omental flap transposition, and vacuum-assisted closure therapy. We report a patient with infection involving a prosthetic graft that was treated with vacuum-assisted closure and transposition of an omental tongue to enable coverage of the exposed graft. (J Vasc Surg 2011;54:1154-6.)
C1 [Impellizzeri, Paul; Dardik, Herbert; Shah, Hemal J.; Brotman-O'Neil, Alissa; Ibrahim, Ibrahim M.] Englewood Hosp & Med Ctr, Dept Vasc Surg, Mt Sinai Sch Med, New York, NY USA.
C3 Englewood Hospital & Medical Center; Icahn School of Medicine at Mount
   Sinai
RP Dardik, H (通讯作者)，Englewood Hosp & Med Ctr, Dept Vasc Surg, Englewood, NJ 07631 USA.
EM hdardik@ehmc.com
RI Shah, Hemal/AAN-4360-2020
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NR 16
TC 6
Z9 9
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD OCT
PY 2011
VL 54
IS 4
BP 1154
EP 1156
DI 10.1016/j.jvs.2011.03.300
PG 3
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 829FA
UT WOS:000295562800032
PM 21723688
OA Bronze
DA 2026-07-24
ER
PT J
AU Banasiewicz, T
   Borejsza-Wysocki, M
   Meissner, W
   Malinger, S
   Szmeja, J
   Koscinski, T
   Ratajczak, A
   Drews, M
AF Banasiewicz, Tomasz
   Borejsza-Wysocki, Maciej
   Meissner, Wiktor
   Malinger, Stanislaw
   Szmeja, Jacek
   Koscinski, Tomasz
   Ratajczak, Andrzej
   Drews, Michal
TI Vacuum-assisted closure therapy in patients with large postoperative
   wounds complicated by multiple fistulas
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Article
DE vacuum-assisted closure (VAC) therapy; topical negative pressure;
   enterocutaneous fistula
ID ENTEROCUTANEOUS FISTULAS; ABDOMINAL WOUNDS; CLINICAL-EXPERIENCE; OPEN
   ABDOMEN; SYSTEM; MANAGEMENT; PRESSURE; TRIAL
AB Vacuum-assisted closure (VAC) therapy is a widely acknowledged method for chronic and traumatic wound healing. The feasibility of VAC therapy used for the treatment of intestinal fistulas is still a subject of debate. Complex postoperative wounds pose significant therapeutic problems, especially when there are several fistula openings in the wound area and other sites, usually at the site of previous drains. This paper describes the treatment of three patients in a critical condition, with complex postoperative wounds complicated by multiple fistulas. Vacuum-assisted closure therapy was based on effective drainage of the biggest fistula opening and ensuring conditions promoting the healing process of other fistulas and the wound. A considerable improvement in general condition and wound healing was noted within 2-4 weeks and both the number of fistulas and the volume of excreted contents decreased. After 5-7 weeks a significant improvement in wound healing was observed in all patients. Once the general condition of all patients was considered satisfactory (2-6 months), they underwent surgery aimed at restoration of the digestive tract continuity In our opinion, VAC therapy used for the treatment of postoperative wounds with multiple fistulas in the wound area and other sites should aim mainly at the improvement of patients' general condition, limitation of the number of fistulas as well as accelerated wound healing. This may lead to formation of one stoma-type fistula, which can be dressed and cared for by patients until the continuity of the digestive tract has been surgically restored.
C1 [Banasiewicz, Tomasz; Borejsza-Wysocki, Maciej; Meissner, Wiktor; Malinger, Stanislaw; Szmeja, Jacek; Koscinski, Tomasz; Ratajczak, Andrzej; Drews, Michal] Poznan Univ Med Sci, Dept Gen Gastroenterol & Endocrine Surg, PL-60355 Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Banasiewicz, T (通讯作者)，Poznan Univ Med Sci, Dept Gen Gastroenterol & Endocrinol Surg, 49 Przybyszewskiego, PL-60355 Poznan, Poland.
EM tbanasiewicz@op.pl
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NR 30
TC 24
Z9 31
U1 0
U2 5
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA WENEDOW ST 9-1, POZNAN, 61-614, POLAND
SN 1895-4588
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2011
VL 6
IS 3
BP 155
EP 163
DI 10.5114/wiitm.2011.24694
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 829IV
UT WOS:000295572700007
PM 23255975
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mohr, Z
   Hirche, C
   Gretschel, S
   Bembenek, A
AF Mohr, Z.
   Hirche, C.
   Gretschel, S.
   Bembenek, A.
TI Risk Factors for the Development of Lymphatic Fistula after Ilioinguinal
   Lymph Node Dissection before Isolated Limb Perfusion and its Potential
   Clinical Relevance
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE lymph fistula; radical lymph node dissection; VAC (R) therapy; isolated
   limb perfusion
ID POSTOPERATIVE MORBIDITY; OPERATIVE MORBIDITY; MALIGNANT-MELANOMA;
   COMPLICATIONS; RADIOTHERAPY; ETIOLOGY
AB Introduction: After ilioinguinal radical lymph node dissection (RLND), the therapy for lymph fistulas constitutes a challenge. Risk factors for the genesis of lymph fistulas have not been sufficiently evaluated. We investigated possible factors that could influence the development of lymph fistulas in patients suffering from malignant melanoma after iloinguinal RLND.
   Patient and Methods: The analysis was related to patients with intransit and lymphonodal metastasised malignant melanoma of the lower limb, who underwent RLND and isolated limb perfusion (ILP). Prospective data acquisition from patients undergoing ilioinguinal RLND and ILP in a one-step approach was performed. The association of lymph fistulas to risk factors was calculated using chi-squared, linear-by-linear test and ROC curves. As possible risk factors we investigated the presence of prior surgery and diabetes mellitus typeII in the medical history, chemotherapeutics, patient age and the body mass index (BMI).
   Results: Postoperative lymph fistula occurred in 11 of 108 patients (10.2 %). A significant association to lymph fistulas was found in BMI (30.2 +/- 7.0 kg/m(2), p<0.02). Other parameters, such as prior surgery (82% vs. 71%), diabetes mellitus typeII (9% vs. 11.7%), chemotherapeutics and patient age (mean 67.8 vs. 62.4 years) showed no influence.
   Conclusion: Our results indicate that the incidence of lymph fistulas after RLND and ILP of malignant melanoma of the lower limb was associated with an increased BMI. Thus, for the prevention of lymph fistulae, an initially alternative wound-closure dressing like vacuum assisted closure (V.A.C.) dressing could be of clinical relevance for obese patients.
C1 [Bembenek, A.] Klinikum Reg Hannover, Viszeralchirurg Klin, D-30655 Hannover, Germany.
   [Mohr, Z.; Hirche, C.; Gretschel, S.; Bembenek, A.] Charite, Robert Rossle Klin, Klin Chirurg & Chirurg Onkol, D-13353 Berlin, Germany.
   [Mohr, Z.] Klinikum Stadt Ludwigshafen Rhein, Ludwigshafen, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Ludwigshafen Hospital
RP Bembenek, A (通讯作者)，Klinikum Reg Hannover, Viszeralchirurg Klin, Sieben Stucken 2-4, D-30655 Hannover, Germany.
EM andreas.bembenek@krh.eu
RI Hirche, Christoph/GYA-4981-2022
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NR 37
TC 6
Z9 7
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD AUG
PY 2011
VL 136
IS 4
BP 386
EP U110
DI 10.1055/s-0030-1262547
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 831GW
UT WOS:000295718400012
PM 21341181
DA 2026-07-24
ER
PT J
AU Wainstein, DE
   Tüngler, V
   Ravazzola, C
   Chara, O
AF Wainstein, Daniel E.
   Tuengler, Victoria
   Ravazzola, Constanza
   Chara, Osvaldo
TI Management of external small bowel fistulae: Challenges and
   controversies confronting the general surgeon
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Review
DE Small bowel; Enterocutaneous fistula; Sub-atmospheric pressure
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE ENTEROCUTANEOUS FISTULAS;
   ABDOMINAL-WALL DEFECTS; GASTROINTESTINAL FISTULAS; RECONSTRUCTIVE
   SURGERY; EXPERIENCE; REPAIR; CLASSIFICATION; RECURRENCE; OCTREOTIDE
AB Background: External small bowel fistulae (ESBF) are serious complications that represent a major challenge for general surgeons. They are still associated with significant morbidity and mortality. This article reviews the management of ESBF with emphasis on the treatment using sub-atmospheric pressure as well a timing, strategies and techniques of reconstructive surgery.
   Methods: Relevant articles from 1960 to 2010 were identified using various electronic databases to review randomized controlled trials, prospective observational studies, retrospective studies and case reports and highlight key references.
   Conclusions: External small bowel fistulae require multidisciplinary management and multimodal approaches with a primary essential focus on early recognition and diminishment of mortality factors such as sepsis and malnutrition. In most cases, the initial treatment is conservative, including clinical and nutritional recovery, output control and extensive local wound care. At this stage, the application of local negative pressure is highly effective. This procedure also allows for a spontaneous closure in many patients. Other cases require careful consideration of surgical reconstruction, knowing that success rates are variable and largely dependent on the patient's condition as well as on local aspects of the lesion. Best surgical results are obtained via intra-peritoneal access with extensive enterolysis, resection of the bowel segment from which the fistulae originate and direct abdominal wall closure. (C) 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [Wainstein, Daniel E.] Hosp E Tornu, Buenos Aires, DF, Argentina.
   [Tuengler, Victoria] Charite Univ Med Berlin, Berlin, Germany.
   [Ravazzola, Constanza; Chara, Osvaldo] Univ Buenos Aires, Fac Med, Dept Fisiol & Biofis, Buenos Aires, DF, Argentina.
   [Chara, Osvaldo] CIC, UNLP, CONICET, Inst Fis Fluidos Sistemas Biol IFLYSIB, La Plata, Argentina.
   [Chara, Osvaldo] Tech Univ Dresden, Ctr Informat Serv & High Performance Comp, D-01062 Dresden, Germany.
C3 University of Buenos Aires; University of Buenos Aires Hospital; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of Buenos Aires; National
   University of La Plata; Consejo Nacional de Investigaciones Cientificas
   y Tecnicas (CONICET); Technische Universitat Dresden
RP Wainstein, DE (通讯作者)，Hosp E Tornu, Buenos Aires, DF, Argentina.
EM dwainstein@telered.com.ar
RI Tüngler, Victoria/AAA-2396-2022; Chara, Osvaldo/T-2798-2019
OI Tüngler, Victoria/0000-0003-3486-2824; Chara,
   Osvaldo/0000-0002-0868-2507
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   WAINSTEIN DE, REV ARGENT IN PRESS
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NR 58
TC 6
Z9 8
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PY 2011
VL 9
IS 3
BP 198
EP 203
DI 10.1016/j.ijsu.2010.11.009
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 832BL
UT WOS:000295775300003
PM 21111073
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Dunn, R
   Hurd, T
   Chadwick, P
   Cote, J
   Cockwill, J
   Mole, T
   Smith, J
AF Dunn, Raymond
   Hurd, Theresa
   Chadwick, P.
   Cote, Julien
   Cockwill, John
   Mole, Trevor
   Smith, Jennifer
TI Factors associated with positive outcomes in 131 patients treated with
   gauze-based negative pressure wound therapy
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Negative Pressure Wound Therapy; Gauze-based NPWT; Wound dimensions;
   Goals of NPWT
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; BRIDGE
AB Negative Pressure Wound Therapy (NPWT) is commonly used in many surgical specialties to improve wound management and healing outcomes. This study reports the ability of gauze-based NPWT to address several treatment goals commonly defined at the onset of therapy. A prospective, multi-center, non-comparative clinical investigation was carried out using gauze-based NPWT in chronic and acute wounds. 131 patients including traumatic, post-surgical and chronic wounds were assessed. Weekly percentage reductions in wound area, depth and volume were 8.3%, 15.8% and 20.5% respectively (p < 0.001). A reduction in exudate level was observed from baseline to treatment discontinuation (p < 0.001). An increase (p = 0.007) in red granulation tissue and a decrease (p < 0.001) in non-viable tissue was observed. Baseline wound characteristics associated with slower rates of progress included chronic wound aetiologies, longer wound duration prior to NPWT and presence of diabetes as a comorbidity. Important indicators of wounds which had improved sufficiently and no longer required NPWT included reduction in volume and exudate levels. Gauze-based NPWT can be used to address many of the treatment goals commonly defined at the onset of therapy including reduction in wound volume, management of exudate and infection status, and improvement in wound bed quality. (C) 2011 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [Mole, Trevor; Smith, Jennifer] Smith & Nephew Wound Management, Kingston Upon Hull HU32BN, N Humberside, England.
   [Cockwill, John] Smith & Nephew Wound Management Inc, St Petersburg, FL USA.
   [Cote, Julien] CHUQ, Quebec City, PQ, Canada.
   [Chadwick, P.] Salford Primary Care Trust, Salford, Lancs, England.
   [Hurd, Theresa] Nursing Practice Solut, Toronto, ON, Canada.
   [Dunn, Raymond] UMass Mem Healthcare, Dept Surg, Div Plast Surg, Worcester, MA USA.
C3 Smith & Nephew; Smith & Nephew; Laval University; Laval University
   Hospital; University of Massachusetts System; University of
   Massachusetts Worcester
RP Smith, J (通讯作者)，Smith & Nephew Wound Management, 101 Hessle Rd, Kingston Upon Hull HU32BN, N Humberside, England.
EM jennifer.smith@smith-nephew.com
FU Smith Nephew
FX Funding for this clinical trial was provided by Smith & Nephew.
   Employees of the study sponsors contributed to study design(T. Mole, J.
   Cockwill), carried out data assessment (T. Mole, J. Smith), statistical
   analysis (T. Mole) and interpretation (J. Smith) and provided medical
   writing services (J. Smith). Authors J. Cote, P. Chadwick, and T. Hurd
   all contributed to data collection and patient evaluation. All authors
   contributed to and approved the manuscript.
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Bollero D, 2007, WOUND REPAIR REGEN, V15, P589, DOI 10.1111/j.1524-475X.2007.00267.x
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   CHARIKER M E, 1989, Contemporary Surgery, V34, P59
   Chariker ME, 2009, PLAST RECONSTR SURG, V123, P1510, DOI 10.1097/PRS.0b013e3181a20563
   DORAFSHAR AH, 2009, AM ASS PLASTIC SURG
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Joseph E, 2000, WOUNDS, V12, P60
   Malmsjö M, 2009, ANN PLAS SURG, V63, P676, DOI 10.1097/SAP.0b013e31819ae01b
   Malmsjö M, 2009, WOUND REPAIR REGEN, V17, P200, DOI 10.1111/j.1524-475X.2009.00461.x
   McCord SS, 2007, WOUND REPAIR REGEN, V15, P296, DOI 10.1111/j.1524-475X.2007.00229.x
   Rinker B, 2008, PLAST RECONSTR SURG, V121, P1664, DOI 10.1097/PRS.0b013e31816a8d9d
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NR 16
TC 7
Z9 9
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PY 2011
VL 9
IS 3
BP 258
EP 262
DI 10.1016/j.ijsu.2010.12.005
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 832BL
UT WOS:000295775300016
PM 21187174
DA 2026-07-24
ER
PT J
AU Penny, HL
   Dyson, M
   Spinazzola, J
   Green, A
   Faretta, M
   Meloy, G
AF Penny, Harry L.
   Dyson, Mary
   Spinazzola, Jeremy
   Green, Adam
   Faretta, Michael
   Meloy, Gregory
TI The Use of Negative-Pressure Wound Therapy with Bio-Dome Dressing
   Technology in the Treatment of Complex Diabetic Wounds
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
ID FOOT WOUNDS
C1 [Penny, Harry L.] Blair Med Associates Wound Clin, Altoona, PA USA.
   [Dyson, Mary] Guys Hosp, Sch Med, Kings Coll, London SE1 9RT, England.
   [Spinazzola, Jeremy] Philadelphia Coll Osteopath Med, Philadelphia, PA USA.
   [Green, Adam; Meloy, Gregory] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA.
   [Faretta, Michael] Penn State Univ, State Coll, PA USA.
C3 Guy's & St Thomas' NHS Foundation Trust; University of London; King's
   College London; Philadelphia College of Osteopathic Medicine; Drexel
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park
RP Penny, HL (通讯作者)，Blair Med Associates Wound Clin, Altoona, PA USA.
CR Ahearn C, 2009, OSTOMY WOUND MANAG, V55, P22
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Baldwin C, 2009, ANN PLAS SURG, V62, P92, DOI 10.1097/SAP.0b013e31817762fd
   de Leon JM, 2009, ADV SKIN WOUND CARE, V22, P122, DOI 10.1097/01.ASW.0000305452.79434.d9
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Kaplan M, 2009, ADV SKIN WOUND CARE, V22, P128, DOI 10.1097/01.ASW.0000305451.71811.d5
   KOZAK GP, 1984, MANAGEMENT DIABETIC, P1
   Malmsjö M, 2009, WOUND REPAIR REGEN, V17, P200, DOI 10.1111/j.1524-475X.2009.00461.x
   Mitra A., 2007, ENGENEX FDN BASED HE
   Orgill DP, 2005, BUSINESS BRIEFING GL, P22
NR 10
TC 3
Z9 3
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1527-7941
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUL
PY 2010
VL 23
IS 7
BP 305
EP 312
DI 10.1097/01.ASW.0000383754.84962.dd
PG 8
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 832YS
UT WOS:000295847500003
PM 20562538
DA 2026-07-24
ER
PT J
AU Ho, CH
   Powell, HL
   Collins, JF
   Bauman, WA
   Spungen, AM
AF Ho, Chester H.
   Powell, Heather L.
   Collins, Joseph F.
   Bauman, William A.
   Spungen, Ann M.
TI Poor Nutrition Is a Relative Contraindication to Negative Pressure Wound
   Therapy for Pressure Ulcers: Preliminary Observations in Patients with
   Spinal Cord Injury
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PREVALENCE
AB OBJECTIVE: To assess the efficacy of negative-pressure wound therapy (NPWT) for healing of pressure ulcers (PrUs) in individuals with spinal-cord injury (SCI).
   DESIGN: Multicenter, 28-day observational study.
   SETTING: Ten Veterans Affairs Medical Center SCI centers.
   PATIENTS: Eighty-six SCI inpatients with Stage III/IV pelvic PrUs.
   INTERVENTIONS: Standard wound care with NPWT versus standard wound care alone (NoNPWT).
   MAIN OUTCOME MEASURES: Change in wound surface area (WSA) using the Verg Videometer Measurement Documentation software.
   MAIN RESULTS: The proportion of patients demonstrating a decrease in WSA (healing subgroup) was not significantly different between the NPWT (n = 33) and NoNPWT (n = 53) groups (67% vs 70%, respectively). In the healing subgroup, there was no significant difference between the NPWT versus NoNPWT groups in WSA decrease (-43 +/- 22% vs -50% +/- 26%, not statistically significant). Similarly, in the nonhealing subgroup, there was no significant difference between NPWT and NoNPWT groups (31% +/- 26% vs 32% +/- 34%). In the NPWT group, the nonhealing subgroup (11/33) had significantly lower serum albumin levels than the healing subgroup (22/33) (2.9 +/- 0.4 vs 3.3 +/- 0.5 mg/dL, P < .05). In the NoNPWT group, there was no significant difference in serum albumin levels between the healing versus nonhealing subgroups (3.2 +/- 0.3 vs 3.2 +/- 0.3 mg/dL).
   CONCLUSION: In SCI patients with Stage III/IV pelvic PrUs, NPWT did not significantly influence the rate of healing. Additionally, in malnourished individuals (albumin <3.0 mg/dL), NPWT was not efficacious. Healing outcomes in the NPWT group were significantly influenced by albumin levels, whereas no such disparity was noted between the healing and nonhealing PrUs for the NoNPWT group. Nutritional status appears to be important in the effectiveness of NPWT.
C1 [Ho, Chester H.; Powell, Heather L.] Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Cleveland, OH USA.
   [Ho, Chester H.; Powell, Heather L.] Case Western Reserve Univ, Dept Phys Med & Rehabil, Cleveland, OH 44106 USA.
   [Collins, Joseph F.] VA Med Ctr, Cooperat Studies Program Coordinating Ctr, Perry Point, MD USA.
   [Bauman, William A.; Spungen, Ann M.] James J Peters VA Med Ctr, RR&D Ctr Excellence Med Consequences Spinal Cord, Bronx, NY USA.
   [Bauman, William A.; Spungen, Ann M.] Mt Sinai Sch Med, Dept Med, New York, NY USA.
   [Bauman, William A.; Spungen, Ann M.] Mt Sinai Sch Med, Dept Rehabil Med, New York, NY USA.
C3 University System of Ohio; Case Western Reserve University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Louis Stokes Cleveland Veterans Affairs Medical Center; University
   System of Ohio; Case Western Reserve University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); James J. Peters
   VA Medical Center; Icahn School of Medicine at Mount Sinai; Icahn School
   of Medicine at Mount Sinai
RI ; Collins, Joe/LBH-9523-2024
OI Ho, Chester/0000-0002-4238-5506; 
FU Department of Veterans Affairs, VA Office of Research and Development,
   Clinical Sciences Service [535]; SCI Service and Rehabilitation Research
   and Development Center of Excellence for the Medical Consequences of
   SCI, VA Medical Center, Bronx, New York [B4162C]
FX Funding for this study was provided by the Department of Veterans
   Affairs, VA Office of Research and Development, Clinical Sciences
   Service, Cooperative Studies Program, CS #535; SCI Service and
   Rehabilitation Research and Development Center of Excellence for the
   Medical Consequences of SCI #B4162C, James J. Peters VA Medical Center,
   Bronx, New York. The authors acknowledge Dr William Krol, as well as the
   following participating sites and site investigators for their effort
   and participation in this project: Charlie Norwood VA Medical Center
   (Augusta, Georgia)-Rose C. Trincher, MD; James J. Peters VA Medical
   Center (Bronx, New York)-George A. Deitrick, MD; Louis Stokes VA Medical
   Center (Cleveland, Ohio)-Chester H. Ho, MD; VA North Texas Healthcare
   System: Dallas VA Medical Center-Lance L. Goetz, MD; Edward Hines Jr VA
   Hospital (Hines, Illinois)-Bernard A. Nemchausky, MD; Michael E. Debakey
   VA Medical Center (Houston, Texas)-Sally A. Holmes, MD; VA Palo Alto
   Health Care System (Palo Alto, California)-Roy Sasaki, MD; Hunter Holmes
   McGuire VA Medical Center (Richmond, Virginia)-Meena Midha, MD; James A.
   Haley Veterans' Hospital (Tampa, Florida)-John L. Merritt, MD; and VA
   Boston Healthcare System, West Roxbury Campus (Boston,
   Massachusetts)-Sunil Sabharwal, MD.
CR [Anonymous], 2003, Cochrane Database of Systematic Reviews
   [Anonymous], 2008, COCHRANE DATABASE SY
   Carlson C., 1992, REHABIL NURS RES, V1, P34
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   DEMPSEY DT, 1988, AM J CLIN NUTR, V47, P352, DOI 10.1093/ajcn/47.2.352
   Garber S.L., 2000, Pressure ulcer prevention and treatment following spinal cord injury: A clinical practice guideline for health-care professionals
   Gasbarro R, 2007, WOUNDS, V19, P2
   Gregor S, 2008, ARCH SURG-CHICAGO, V143, P189, DOI 10.1001/archsurg.2007.54
   Haghpanah S, 2006, ARCH PHYS MED REHAB, V87, P1396, DOI 10.1016/j.apmr.2006.06.014
   Hess CL, 2003, ANN PLAS SURG, V51, P210, DOI 10.1097/01.SAP.0000058513.10033.6B
   Joseph E, 2000, WOUNDS, V12, P60
   Kennedy Andrew, 2006, Physiotherapy Theory and Practice, V22, P83, DOI 10.1080/09593980600588781
   Lindsey L, 2000, SPINAL CORD INJURY I
   Luckraz H, 2003, J THORAC CARDIOV SUR, V125, P301, DOI 10.1067/mtc.2003.74
   McKinley WO, 1999, ARCH PHYS MED REHAB, V80, P1402, DOI 10.1016/S0003-9993(99)90251-4
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Schwien T, 2005, OSTOMY WOUND MANAG, V51, P47
   Sibbald R Gary, 2003, Ostomy Wound Manage, V49, P52
   van Rijswijk Lia, 2005, Ostomy Wound Manage, VSuppl, P7
   Whitney J, 2006, WOUND REPAIR REGEN, V14, P663, DOI 10.1111/j.1524-475X.2006.00175.x
   Yarkony Gary M., 1995, P100
NR 21
TC 17
Z9 19
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2010
VL 23
IS 11
BP 508
EP 516
DI 10.1097/01.ASW.0000390493.43835.ec
PG 9
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 832ZF
UT WOS:000295849100004
PM 20975334
DA 2026-07-24
ER
PT J
AU Sakellariou, VI
   Mavrogenis, AF
   Papagelopoulos, PJ
AF Sakellariou, Vasileios I.
   Mavrogenis, Andreas F.
   Papagelopoulos, Panayiotis J.
TI Negative-Pressure Wound Therapy for Musculoskeletal Tumor Surgery
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative pressure wound therapy (NPWT); negative pressure wound therapy
   in musculoskeletal tumor surgery; vacuum-assisted closure in
   musculoskeletal tumor surgery
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; INFECTIONS; RADIATION; TRIAL;
   DEBRIDEMENT; DEVICE
AB OBJECTIVE: To evaluate the effect of negative-pressure wound therapy in musculoskeletal tumor surgery patients.
   MATERIALS AND METHODS: The authors analyzed the medical records of 32 patients treated at the authors' institution for bone and soft-tissue sarcomas and secondary wound-healing complications, from 2005 to 2008; there were 11 men and 21 women, with a mean age of 56 years (range, 35-72 years).
   RESULTS: A statistically significant difference (P = .036) was found regarding the length of hospitalization in the conventional wound treatment group, group A (mean, 25.2 days; range, 15-52 days), compared with the negative wound pressure therapy group, group B (mean, 16.5 days; range, 12-33 days).
   CONCLUSIONS: The use of negative-pressure wound therapy for the management of complicated wound healing in sarcoma patients following tumor surgery is safe and effective and is associated with lower overall complications rates, infection rate, and the need for further surgery and a lower total cost of wound-healing treatment.
C1 [Sakellariou, Vasileios I.] Univ Athens, Sch Med, Dept Orthopaed 1, Attikon Gen Hosp, GR-11527 Athens, Greece.
   [Mavrogenis, Andreas F.] Rizzoli Inst Bologna, Dept Orthopaed, Musculoskeletal Tumor Unit, Bologna, Italy.
   [Papagelopoulos, Panayiotis J.] Univ Athens, Sch Med, Dept Orthopaed 1, Musculoskeletal Tumor Unit, GR-11527 Athens, Greece.
C3 University Hospital Attikon; National & Kapodistrian University of
   Athens; National & Kapodistrian University of Athens
RP Sakellariou, VI (通讯作者)，Univ Athens, Sch Med, Dept Orthopaed 1, Attikon Gen Hosp, GR-11527 Athens, Greece.
RI Papagelopoulos, Panayiotis/AAR-9492-2020
CR Andrews BT, 2006, LARYNGOSCOPE, V116, P1918, DOI 10.1097/01.mlg.0000235935.07261.98
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NR 43
TC 16
Z9 17
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2011
VL 24
IS 1
BP 25
EP 30
DI 10.1097/01.ASW.0000392924.75970.b9
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 833AA
UT WOS:000295851900006
PM 21173588
DA 2026-07-24
ER
PT J
AU Gabriel, A
   Gialich, S
   Kirk, J
   Edwards, S
   Beck, B
   Sorocéanu, A
   Nelson, S
   Gabriel, C
   Gupta, S
AF Gabriel, Allen
   Gialich, Shelby
   Kirk, Julie
   Edwards, Sheriden
   Beck, Brooke
   Soroceanu, Alexandra
   Nelson, Scott
   Gabriel, Cassie
   Gupta, Subhas
TI The Haiti Earthquake: The Provision of Wound Care for Mass Casualties
   Utilizing Negative-Pressure Wound Therapy
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative-pressure wound therapy; modern care in Haiti; reticulated
   open-cell foam dressings; limb salvage
ID VACUUM-ASSISTED CLOSURE; GROWTH-FACTORS; INFECTIONS; EXPERIENCE;
   MECHANISMS; INJURIES; DISASTER; TRAUMA; IRAQ
AB Many months after the devastating earthquake in January 2010, wounds remain a major disease burden in Haiti. Since January 2010, through the efforts of corporations, nonprofit charitable organizations, and medical professionals, advanced wound care techniques, including negative-pressure wound therapy (NPWT), have been introduced into the wound care regimens of various hospitals in Haiti. In June 2010, the authors completed their second volunteer trip at a Haitian hospital specializing in orthopedic wounds. The medical team was composed of a plastic surgeon, orthopedic surgeon, anesthesiologist, medical assistant, scrub technician, and registered nurse (specializing in plastic surgery and orthopedics). The authors' team supplied NPWT devices, reticulated open-cell foam dressings, and canisters donated by Kinetic Concepts, Inc, San Antonio, Texas, for use at the hospital. This report describes the medical challenges in postearthquake Haiti (including limb salvage and infection), benefits of adjunctive use of NPWT/reticulated open-cell foam, and current wound care status in a Haitian orthopedic hospital. The future role of NPWT in Haiti and during mass catastrophe in a least-developed country is also discussed.
C1 [Gabriel, Allen; Gialich, Shelby; Kirk, Julie; Edwards, Sheriden] SW Washington Med Ctr, Dept Surg, Vancouver, WA 98664 USA.
   [Gabriel, Allen; Gupta, Subhas] Loma Linda Univ, Med Ctr, Dept Plast Surg, Loma Linda, CA 92350 USA.
   [Beck, Brooke] Loma Linda Univ, Global Hlth Inst, Loma Linda, CA 92350 USA.
   [Soroceanu, Alexandra] Dalhousie Univ, Queen Elizabeth II Hlth Sci Ctr, Dept Orthoped Surg, Halifax, NS, Canada.
   [Nelson, Scott] Loma Linda Univ, Dept Orthoped Surg, Med Ctr, Loma Linda, CA 92350 USA.
   [Gabriel, Cassie] Columbia Anesthesia Grp, Vancouver, WA USA.
C3 Loma Linda University; Loma Linda University; Queen Elizabeth II Health
   Sciences Centre; Dalhousie University; Loma Linda University
RP Gabriel, A (通讯作者)，SW Washington Med Ctr, Dept Surg, Vancouver, WA 98664 USA.
RI Gupta, Subhas/C-5458-2018; Gabriel, Allen/AFK-3548-2022; Soroceanu,
   Alex/JNR-2108-2023
OI Gupta, Subhas/0000-0001-5091-3922; 
CR Ahern M, 2005, EPIDEMIOL REV, V27, P36, DOI 10.1093/epirev/mxi004
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NR 41
TC 3
Z9 4
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD OCT
PY 2011
VL 24
IS 10
BP 456
EP 462
DI 10.1097/01.ASW.0000406473.36176.79
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 833FZ
UT WOS:000295869200003
PM 21926673
DA 2026-07-24
ER
PT J
AU Birke-Sorensen, H
   Malmsjo, M
   Rome, P
   Hudson, D
   Krug, E
   Berg, L
   Bruhin, A
   Caravaggi, C
   Chariker, M
   Depoorter, M
   Dowsett, C
   Dunn, R
   Duteille, F
   Ferreira, F
   Martínez, JMF
   Grudzien, G
   Ichioka, S
   Ingemansson, R
   Jeffery, S
   Lee, C
   Vig, S
   Runkel, N
   Martin, R
   Smith, J
AF Birke-Sorensen, H.
   Malmsjo, M.
   Rome, P.
   Hudson, D.
   Krug, E.
   Berg, L.
   Bruhin, A.
   Caravaggi, C.
   Chariker, M.
   Depoorter, M.
   Dowsett, C.
   Dunn, R.
   Duteille, F.
   Ferreira, F.
   Francos Martinez, J. M.
   Grudzien, G.
   Ichioka, S.
   Ingemansson, R.
   Jeffery, S.
   Lee, C.
   Vig, S.
   Runkel, N.
   Martin, R.
   Smith, J.
CA Int Expert Panel Negative Pressure
TI Evidence-based recommendations for negative pressure wound therapy:
   Treatment variables (pressure levels, wound filler and contact layer) -
   Steps towards an international consensus
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Negative pressure wound therapy (NPWT); Recommendations; Systematic
   review; Consensus; NPWT wound-filler materials; Negative pressure level
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; MICROVASCULAR
   BLOOD-FLOW; SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE; BACTERIAL
   BIOBURDEN; COST-EFFECTIVENESS; RANDOMIZED-TRIAL; DRESSING CHANGES;
   INFECTED WOUNDS
AB Negative pressure wound therapy (NPWT) is becoming a commonplace treatment in many clinical settings. New devices and dressings are being introduced. Despite widespread adoption, there remains uncertainty regarding several aspects of NPWT use. To respond to these gaps, a global expert panel was convened to develop evidence-based recommendations describing the use of NPWT. In a previous communication, we have reviewed the evidence base for the use of NPWT within trauma and reconstructive surgery. In this communication, we present results of the assessment of evidence relating to the different NPWT treatment variables: different wound fillers (principally foam and gauze); when to use a wound contact layer; different pressure settings; and the impact of NPWT on bacterial bioburden. Evidence-based recommendations were obtained by a systematic review of the literature, grading of evidence and drafting of the recommendations by a global expert panel.
   Evidence and recommendations were graded according to the Scottish Intercollegiate Guidelines Network (SIGN) classification system.
   In general, there is relatively weak evidence on which to base recommendations for any one NPWT treatment variable over another. Overall, 14 recommendations were developed: five for the choice of wound filler and wound contact layer, four for choice of pressure setting and five for use of NPWT in infected wounds. With respect to bioburden, evidence suggests that reduction of bacteria in wounds is not a major mode of action of NPWT. (C) 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Runkel, N.] Black Forest Hosp, Dept Gen Surg, Villingen, Germany.
   [Runkel, N.] Univ Freiburg, D-7800 Freiburg, Germany.
   [Birke-Sorensen, H.] Hamlet Hosp, Aarhus, Denmark.
   [Malmsjo, M.] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Malmsjo, M.] Skane Univ Hosp, Lund, Sweden.
   [Rome, P.] Royal Prince Alfred Hosp, Sydney, NSW, Australia.
   [Rome, P.] Concord Hosp, Sydney, NSW, Australia.
   [Hudson, D.] Groote Schuur Hosp, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
   [Krug, E.] Leiden Univ, Med Ctr, NL-2300 RA Leiden, Netherlands.
   [Berg, L.] Kuopio Univ Hosp, Kuopio, Finland.
   [Bruhin, A.] Dept Trauma & Visceral Surg, Luzern, Switzerland.
   [Caravaggi, C.] Inst Clin Citta Studi Milan, Ctr Treatment Diabet Foot Pathol, Milan, Italy.
   [Chariker, M.] Aesthet Plast Surg Inst, Louisville, KY USA.
   [Depoorter, M.] Acad Hosp St Jan, Dept Plast & Reconstruct Surg, Brugge, Belgium.
   [Dowsett, C.] E London NHS Fdn Trust, Community Hlth Newham Directorate, London, England.
   [Dunn, R.] Univ Massachusetts, Sch Med, Div Plast Surg, Worcester, MA 01605 USA.
   [Dunn, R.] Mem Hlth Care, Worcester, MA USA.
   [Duteille, F.] Hop Hotel Dieu, Plast Aesthet & Reconstruct Surg Burn Unit, Nantes, France.
   [Ferreira, F.] Hosp Pedro Hispano, Matosinhos Porto, Portugal.
   [Francos Martinez, J. M.] Hosp Univ Bellvitge, Endocrine Surg Unit, Barcelona, Spain.
   [Grudzien, G.] John Paul 2 Hosp, Dept Cardiovasc Surg & Transplantol, Krakow, Poland.
   [Ichioka, S.] Saitama Med Univ, Dept Plast & Reconstruct Surg, Saitama, Japan.
   [Ingemansson, R.] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, Lund, Sweden.
   [Jeffery, S.] Queen Elizabeth Hosp, Royal Ctr Def Med, Birmingham B15 2TH, W Midlands, England.
   [Lee, C.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Lee, C.] St Marys Hosp, San Francisco, CA USA.
   [Vig, S.] Mayday Univ Hosp, London, England.
C3 University of Freiburg; Lund University; Lund University; Skane
   University Hospital; NSW Health; Royal Prince Alfred Hospital;
   University of Sydney; Concord Repatriation General Hospital; University
   of Cape Town; Leiden University - Excl LUMC; Leiden University; Leiden
   University Medical Center (LUMC); University of Eastern Finland;
   University of Eastern Finland Hospital; Kuopio University Hospital;
   University of Massachusetts System; University of Massachusetts
   Worcester; Nantes Universite; CHU de Nantes; University of Barcelona;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; Saitama Medical University; Lund University; Skane
   University Hospital; University of Birmingham; Royal Centre for Defence
   Medicine; University of California System; University of California San
   Francisco; Croydon University Hospital
RP Runkel, N (通讯作者)，Black Forest Hosp, Dept Gen Surg, Villingen, Germany.
EM norbert.runkel@sbk-vs.de
RI jeffery, steven/A-5207-2013; Birke-Sørensen, Hanne/B-6733-2015
OI jeffery, steven/0000-0001-6587-5412; Ingemansson,
   Richard/0000-0001-7623-8953; Martin, Robin/0000-0002-9314-0437; Maljö,
   Malin/0000-0001-9849-9599; 
FU Smith Nephew
FX Authors Jenny Smith and Robin Martin are employees of Smith & Nephew.
   The International Expert Panel on Negative Pressure Wound Therapy
   (EP-NPWT) is funded by an unrestricted educational grant provided by
   Smith & Nephew. Where no further conflicts of interest are stated, none
   is known to exist. In addition to this funding, the following financial
   relationships exist:
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NR 122
TC 148
Z9 179
U1 0
U2 42
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD SEP
PY 2011
VL 64
SU 1
BP S1
EP S16
DI 10.1016/j.bjps.2011.06.001
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 835QI
UT WOS:000296050500001
PM 21868296
DA 2026-07-24
ER
PT J
AU Rammelt, S
   Olbrich, A
   Zwipp, H
AF Rammelt, S.
   Olbrich, A.
   Zwipp, H.
TI Hindfoot amputations
SO OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE
LA German
DT Article
DE Foot; Chopart amputation; Pirogoff amputation; Syme amputation;
   Disarticulation
ID ANKLE DISARTICULATION; SYME; PIROGOFF; FOOT
AB Obtaining a durable, weight-bearing stump with minimal or no loss of limb length, and stable soft tissue coverage with preservation of the original sensation of the sole of the foot at the heel.
   Complex trauma to the foot with devitalized or nonreconstructable forefoot and midfoot, deep bony and soft tissue infection, infected Charcot foot with threatening sepsis, necrosis or gangrene of the forefoot and midfoot with vasculopathy, malignant tumors, certain infections, gigantism of the forefoot.
   Possible reconstruction of the midfoot and forefoot beyond the midtarsal (Chopart) joint, loss or irreversible destruction of the sole of the foot or the distal tibial metaphysis.
   The skin incision is designed to retain a long plantar flap with a maximum amount of weight-bearing sole 5-7 cm below amputation level and a shorter anterior flap 1-2 cm below amputation level. Exarticulation or bone resection is performed from anterior to posterior, while preserving the posteromedial vessels to supply the heel flap. The Chopart stump is held in a neutral position avoiding equinus with a tibiotalar external fixator and additional tendon balancing with a noninfected posterior tibialis and one of the peronaeal tendons from medial and lateral through the talar head and Achilles tendon lengthening. Alternatively, a Pirogoff stump with minimal limb length loss (about 2 cm) is achieved with minimal resection at the anterior calcaneal process. The calcaneus is rotated 70-80A degrees and fused to the distal end of the tibia with lag screws or an external frame. Alternatively, a Syme stump is covered with the heel skin after resection of the malleoli flush to the tibial plafond. If anterior wound closure cannot be obtained without tension, temporary vacuum-assisted closure and later definitive coverage with skin grafts, local or free flaps is obtained. In cases of deep infection, the amputation is performed as a staged procedure.
   Nonweight bearing until stable scar formation, early mobilization in a total contact cast. Interim prosthesis after 2-4 weeks, fitting of the definitive prosthesis with special shoewear after 2-3 months.
   Over a 12-year period, 15 Chopart, 7 Pirogoff, and 2 Syme amputations were performed. A total of 15 patients had sustained a complex foot trauma, 9 had a deep infection, among them 7 in a diabetic Charcot foot. In 16 patients, among them all with deep infection, 1-4 planned revisions were performed. In 5 patients (20.8%), the stumps were revised subacutely to a more proximal amputation level. In 2 patients with Chopart amputation, a hindfoot fusion was performed to correct equinus, while 1 Chopart and 1 Pirogoff stump were subjected to resection of a prominent exostosis. Except for 2 patients with Charcot foot, all patients with hindfoot amputation could walk barefoot over short distances.
C1 [Rammelt, S.; Olbrich, A.; Zwipp, H.] Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Klin & Poliklin Unfall & Wiederherstellungsschiru, D-01307 Dresden, Germany.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital
RP Rammelt, S (通讯作者)，Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Klin & Poliklin Unfall & Wiederherstellungsschiru, Fetscherstr 74, D-01307 Dresden, Germany.
EM stefan.rammelt@uniklinikum-dresden.de
RI Rammelt, Stefan/AAE-5863-2019
OI Rammelt, Stefan/0000-0003-1141-6493
CR [Anonymous], 1939, JBJS
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   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
NR 25
TC 16
Z9 17
U1 0
U2 5
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0934-6694
J9 OPER ORTHOP TRAUMATO
JI Oper. Orthopade Traumatol.
PD OCT
PY 2011
VL 23
IS 4
BP 265
EP 279
DI 10.1007/s00064-011-0042-x
PG 15
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 836AR
UT WOS:000296079200003
PM 21922229
DA 2026-07-24
ER
PT J
AU Sumpio, B
   Thakor, P
   Mahler, D
   Blume, P
AF Sumpio, Bauer
   Thakor, Pratapji
   Mahler, David
   Blume, Peter
TI Negative Pressure Wound Therapy as Postoperative Dressing in Below Knee
   Amputation Stump Closure of Patients With Chronic Venous Insufficiency
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; MECHANISMS; INJURIES; TRAUMA
AB The role of negative pressure wound therapy (NPWT) in below knee amputation (BKA) stump closure is not well described. The purpose of this series was to analyze morbidity outcomes, particularly related to dehiscence, of BKAs treated with postoperative NPWT prior to definitive closure. Methods. Medical records were retrospectively reviewed from six patients with large diameter legs due to chronic venous insufficiency of Charcot disease, who underwent a BKA and received postoperative NPWT between April 2006 and December 2008. NPWT was applied as a postsurgical dressing over closed fascia to help condition the open stump for successful closure. Mean patient age was 56 years. The average hospital stay after BKA was 10 days (range, 6-15 days). Average duration of NPWT was 7 days (range, 4-9 days). Results. All patients survived to discharge. Complete reepithelialization and healing of the stump averaged 84 days (range, 39-182 days) following initial placement of NPWT. Patients were casted for prosthesis in an average of 90 days (range, 42-187 days). The average follow-up time was 311 days (range, 210-440 days). None of the wounds dehisced or required repeat procedures during follow up. Complete wound closure was achieved in all cases, and no local or systemic complications were recorded for any of the patients. Conclusion. This experience suggests that early, short-term application of NPWT may be a valuable adjunct in BKA stump closure.
C1 [Sumpio, Bauer] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06520 USA.
   [Thakor, Pratapji] Affiliated Foot & Ankle Surg, New Haven, CT USA.
   [Blume, Peter] Yale Univ, Sch Med, Sect Podiatr Surg, New Haven, CT USA.
C3 Yale University; Yale University
RP Sumpio, B (通讯作者)，Yale Univ, Sch Med, Dept Surg, POB 208062, New Haven, CT 06520 USA.
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NR 30
TC 8
Z9 8
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2011
VL 23
IS 10
BP 301
EP 308
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 838NN
UT WOS:000296299400003
PM 25881107
DA 2026-07-24
ER
PT J
AU Lessing, C
   Slack, P
   Hong, KZ
   Kilpadi, D
   McNulty, A
AF Lessing, Chris
   Slack, Paul
   Hong, K. Z.
   Kilpadi, Deepak
   McNulty, Amy
TI Negative Pressure Wound Therapy With Controlled Saline Instillation
   (NPWTi): Dressing Properties and Granulation Response In Vivo
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FIBROBLASTS
AB Negative pressure wound therapy (NPWT) with reticulated open-cell foam (ROCF) dressings (ROCF G, V.A.C.(R) GranuFoam (TM) Dressing, KCI USA, Inc, San Antonio, TX) creates a healing environment that removes wound exudates, reduces edema, and promotes perfusion and granulation tissue formation. Controlled instillation of saline during NPWT (NPWTi) may further enhance healing by facilitating automatic and contained volumetric wound irrigation and cleansing. A new ROCF dressing (ROCF-V, V.A.C. VeraFlo (TM) Dressing, KCI USA, Inc, San Antonio, TX) has been developed for use with NPWTi; benchtop and in vivo tests compared the properties and performance of both ROCF-G and ROCF-V. Pore size and density (contributors to microdeformation) are similar for both ROCF-G and ROCF-V, while mechanical testing demonstrates ROCF-V is stronger than ROCF-G under both tensile and tear loading. ROCF-V surface energy is higher than ROCF-G, making ROCF-V less hydrophobic. Under wet conditions ROCF-V wicks more fluid and shows less pressure drop than ROCF-G, suggesting ROCF-V may be better suited for NPWTi. After 7 days of therapy in a porcine full-thickness excisional wound model, NPWTi with ROCF-V resulted in a 43% increase (P < 0.05) in granulation tissue thickness compared to NPWT with ROCF-G. These data suggest NPWTi with ROCF-V creates a wound healing environment that provides enhanced granulation tissue formation compared to standard NPWT with ROCF-G.
C1 [Lessing, Chris; Slack, Paul; Hong, K. Z.; Kilpadi, Deepak; McNulty, Amy] Kinet Concepts Inc, San Antonio, TX 78249 USA.
RP Lessing, C (通讯作者)，Kinet Concepts Inc, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM chris.lessing@kci1.com
OI Lessing, Chris/0009-0001-5009-6624
FU KCI USA, Inc.
FX This study was financially supported by KCI USA, Inc. All of the authors
   are employed by KCI USA, Inc.
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NR 22
TC 44
Z9 52
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2011
VL 23
IS 10
BP 309
EP 319
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 838NN
UT WOS:000296299400004
PM 25881108
DA 2026-07-24
ER
PT J
AU Masumoto, K
   Nagata, K
   Oka, Y
   Kai, H
   Yamaguchi, S
   Wada, M
   Kusuda, T
   Hara, T
   Hirose, S
   Iwasaki, A
   Taguchi, T
AF Masumoto, Kouji
   Nagata, Kouji
   Oka, Yoichiro
   Kai, Hiroki
   Yamaguchi, Sadako
   Wada, Mika
   Kusuda, Tsuyoshi
   Hara, Toshiro
   Hirose, Shin-ichi
   Iwasaki, Akinori
   Taguchi, Tomoaki
TI Successful treatment of an infected wound in infants by a combination of
   negative pressure wound therapy and arginine supplementationu
SO NUTRITION
LA English
DT Article
DE Arginine; Children; Negative pressure wound therapy; Surgical site
   infection; Wound dehiscence
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTIONS; MANAGEMENT
AB Objective: Wound dehiscence caused by surgical site infection (SSI) presents a complicated problem. Negative pressure wound therapy (NPWT) was developed to treat wound dehiscence. Nutritional treatment using arginine has also been recently shown to be effective for the treatment of pressure ulcers. Therefore, wound complications due to SSI were treated using NPWT combined with nutritional therapy with an arginine-rich supplement (ARS).
   Methods: Six pediatric patients with wound dehiscence due to SSI received this combined therapy.
   Results: The average age of the patients was 12.2 mo. The operations that these patients underwent included laryngotracheal separation, radical operation for spinal bifida, gastrostomy, colostomy, anorectoplasty, and tumor extirpation. A local wound infection induced wound dehiscence in all patients. Therefore, NPWT was introduced with an enteral administration of ARS. All wounds completely healed within 1 mo after the introduction of this combined therapy without any other complications from the NPWT or ARS. A follow-up study at 6 mo after this therapy was completed showed no complications associated with the wounds.
   Conclusion: This combination therapy using NPWT and ARS administration was effective in inducing early healing of infected wound complications after surgery. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Masumoto, Kouji; Nagata, Kouji; Taguchi, Tomoaki] Kyushu Univ, Grad Sch Med Sci, Dept Pediat Surg Reprod & Dev Med, Kyushu, Japan.
   [Masumoto, Kouji; Oka, Yoichiro; Kai, Hiroki; Iwasaki, Akinori] Fukuoka Univ, Fac Med, Dept Thorac Endocrine & Pediat Surg, Fukuoka 81401, Japan.
   [Yamaguchi, Sadako; Wada, Mika] Kyushu Univ Hosp, Nutr Support Team, Kyushu, Japan.
   [Kusuda, Tsuyoshi; Hara, Toshiro] Kyushu Univ Hosp, Neonatal Intens Care Unit, Kyushu, Japan.
   [Hirose, Shin-ichi] Fukuoka Univ, Dept Pediat, Fac Med, Fukuoka 81401, Japan.
C3 Kyushu University; Fukuoka University; Kyushu University; Kyushu
   University; Fukuoka University
RP Masumoto, K (通讯作者)，Kyushu Univ, Grad Sch Med Sci, Dept Pediat Surg Reprod & Dev Med, Kyushu, Japan.
EM kmasu@fukuoka-u.ac.jp
RI ; Nagata, Kouji/AAH-7315-2021
OI HIROSE, Shinichi/0000-0001-6796-3790; 
FU Ministry of Education and Science in Japan
FX This work was supported in part by a Grant-in-Aid for Scientific
   Research from the Ministry of Education and Science in Japan.
CR Alves CC, 2010, NUTRITION, V26, P873, DOI 10.1016/j.nut.2010.05.003
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   Sobotka L, 2010, NUTRITION, V26, P856, DOI 10.1016/j.nut.2010.05.010
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   Upperman Jeffrey S, 2005, Pediatr Crit Care Med, V6, pS36, DOI 10.1097/01.PCC.0000161584.26999.15
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   Wild T, 2010, NUTRITION, V26, P862, DOI 10.1016/j.nut.2010.05.008
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NR 23
TC 9
Z9 11
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD NOV-DEC
PY 2011
VL 27
IS 11-12
BP 1141
EP 1145
DI 10.1016/j.nut.2011.01.006
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 838RN
UT WOS:000296310000009
PM 21621390
DA 2026-07-24
ER
PT J
AU Caterino, S
   Chieco, PA
   Virgilio, E
   Kazemi, A
   Lorenzon, L
AF Caterino, Salvatore
   Chieco, Paola Addario
   Virgilio, Edoardo
   Kazemi, Andrea
   Lorenzon, Laura
TI Percutaneous Drainage and Vacuum-Assisted Closure System in the
   Management of a Sigmoid Cancer Presenting with an Abscess of the
   Anterior Abdominal Wall
SO AMERICAN SURGEON
LA English
DT Article
C1 [Caterino, Salvatore; Chieco, Paola Addario; Virgilio, Edoardo; Kazemi, Andrea; Lorenzon, Laura] Univ Roma La Sapienza, St Andrea Hosp, Fac Med & Psychol, Surg & Med Dept Clin Sci Biomed Technol & Transla, I-00189 Rome, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea
RP Lorenzon, L (通讯作者)，Univ Roma La Sapienza, St Andrea Hosp, Fac Med & Psychol, Surg & Med Dept Clin Sci Biomed Technol & Transla, Via Grottarossa 1035-39, I-00189 Rome, Italy.
EM laura.lorenzon@uniroma1.it
RI VIRGILIO, EDOARDO/B-4965-2015; Nava, Andrea/ABC-4232-2020; Lorenzon,
   Laura/AAB-9498-2022
OI VIRGILIO, EDOARDO/0000-0002-9324-3487; 
CR Draus JM, 2006, SURGERY, V140, P570, DOI 10.1016/j.surg.2006.07.003
   Stollman NH, 1999, AM J GASTROENTEROL, V94, P3110, DOI 10.1111/j.1572-0241.1999.01501.x
   THURNAM J, 1846, T PATHOL SOC LOND, V1, P265
   Tsai HL, 2007, INT J COLORECTAL DIS, V22, P15, DOI 10.1007/s00384-006-0097-6
NR 4
TC 2
Z9 3
U1 0
U2 3
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD NOV
PY 2011
VL 77
IS 11
BP E226
EP E228
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 838UE
UT WOS:000296316900038
PM 22196631
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Malmsjö, M
   Hansson, J
   Hlebowicz, J
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Hansson, Johan
   Hlebowicz, Joanna
   Ingemansson, Richard
TI Macroscopic changes during negative pressure wound therapy of the open
   abdomen using conventional negative pressure wound therapy and NPWT with
   a protective disc over the intestines
SO BMC SURGERY
LA English
DT Article
DE negative pressure wound therapy open abdomen; macroscopic changes;
   intestinal wall
ID VACUUM-ASSISTED CLOSURE; TRIAL COMPARING POLYGLACTIN-910-MESH; TEMPORARY
   ABDOMINAL CLOSURE; VENTRAL HERNIA RATE; FASCIAL CLOSURE
AB Background: Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) than with other wound management techniques. However, the method has occasionally been associated with increased development of fistulae. We have previously shown that NPWT induces ischemia in the underlying small intestines close to the vacuum source, and that a protective disc placed between the intestines and the vacuum source prevents the induction of ischemia. In the present study we compare macroscopic changes after 12, 24, and 48 hours, using conventional NPWT and NPWT with a protective disc between the intestines and the vacuum source.
   Methods: Twelve pigs underwent midline incision. Six animals underwent conventional NPWT, while the other six pigs underwent NPWT with a protective disc inserted between the intestines and the vacuum source. Macroscopic changes were photographed and quantified after 12, 24, and 48 hours of NPWT.
   Results: The surface of the small intestines was red and mottled as a result of petechial bleeding in the intestinal wall in all cases. After 12, 24 and 48 hours of NPWT, the area of petechial bleeding was significantly larger when using conventional NPWT than when using NPWT with the protective disc (9.7 +/- 1.0 cm(2) vs. 1.8 +/- 0.2 cm(2), p < 0.001, 12 hours), (14.5 +/- 0.9 cm(2) vs. 2.0 +/- 0.2 cm(2), 24 hours) (17.0 +/- 0.7 cm(2) vs. 2.5 +/- 0.2 cm(2) with the disc, p < 0.001, 48 hours)
   Conclusions: The areas of petechial bleeding in the small intestinal wall were significantly larger following conventional NPWT after 12, 24 and 48 hours, than using NPWT with a protective disc between the intestines and the vacuum source. The protective disc protects the intestines, reducing the amount of petechial bleeding.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Lindstedt, Sandra; Malmsjo, Malin; Hlebowicz, Joanna; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Hansson, Johan] Uppsala Univ, Inst Surg Sci, Fac Med, Uppsala, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Uppsala University; Lund University
RP Lindstedt, S (通讯作者)，Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
EM sandra.lindstedt@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953; Lindstedt, Sandra/0000-0003-4484-6473
CR Becker HP, 2007, SCAND J SURG, V96, P263, DOI 10.1177/145749690709600402
   Bee TK, 2008, J TRAUMA, V65, P337, DOI 10.1097/TA.0b013e31817fa451
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   Fischer JE, 2008, AM J SURG, V196, P1, DOI 10.1016/j.amjsurg.2008.01.001
   Kaplan M., 2004, OSTOMY WOUND MANAG S, V50, P1
   Kaplan M, 2004, OSTOMY WOUND MANAG S, V50
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   Trevelyan S L, 2009, J Wound Care, V18, P24
NR 18
TC 8
Z9 9
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD APR 29
PY 2011
VL 11
AR 10
DI 10.1186/1471-2482-11-10
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 840OB
UT WOS:000296449000001
PM 21529362
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Borgquist, O
   Anesäter, E
   Hedström, E
   Lee, CK
   Ingemansson, R
   Malmsjö, M
AF Borgquist, Ola
   Anesater, Erik
   Hedstrom, Erik
   Lee, Charles K.
   Ingemansson, Richard
   Malmsjo, Malin
TI Measurements of wound edge microvascular blood flow during negative
   pressure wound therapy using thermodiffusion and transcutaneous and
   invasive laser Doppler velocimetry
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MICROCIRCULATION; VALIDATION; GAUZE; FOAM
AB The effects of negative pressure wound therapy (NPWT) on wound edge microvascular blood flow are not clear. The aim of the present study was therefore to further elucidate the effects of NPWT on periwound blood flow in a porcine peripheral wound model using different blood flow measurement techniques. NPWT at -20, -40, -80, and -125 mmHg was applied to a peripheral porcine wound (n = 8). Thermodiffusion, transcutaneous, and invasive laser Doppler velocimetry were used to measure the blood perfusion 0.5, 1.0, and 2.5 cm from the wound edge. Thermodiffusion (an invasive measurement technique) generally showed a decrease in perfusion close to the wound edge (0.5 cm), and an increase further from the edge (2.5 cm). Invasive laser Doppler velocimetry showed a similar response pattern, with a decrease in blood flow 0.5 cm from the wound edge and an increase further away. However, 1.0 cm from the wound edge blood flow decreased with high pressure levels and increased with low pressure levels. A different response pattern was seen with transcutaneous laser Doppler velocimetry, showing an increase in blood flow regardless of the distance from the wound edge (0.5, 1.0, and 2.5 cm). During NPWT, both increases and decreases in blood flow can be seen in the periwound tissue depending on the distance from the wound edge and the pressure level. The pattern of response depends partly on the measurement technique used. The combination of hypoperfusion and hyperperfusion caused by NPWT may accelerate wound healing.
C1 [Borgquist, Ola] Lund Univ, Dept Anesthesiol & Intens Care, Lund, Sweden.
   [Borgquist, Ola; Anesater, Erik; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Borgquist, Ola; Anesater, Erik; Hedstrom, Erik; Ingemansson, Richard; Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
   [Hedstrom, Erik] Lund Univ, Dept Clin Physiol, Lund, Sweden.
   [Lee, Charles K.] Univ Calif San Francisco, Div Plast & Reconstruct Surg, San Francisco, CA 94143 USA.
   [Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Lund University; Skane University
   Hospital; Lund University; University of California System; University
   of California San Francisco; Lund University
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Borgquist, Ola/AAO-6451-2020
OI Maljö, Malin/0000-0001-9849-9599; Hedström, Erik/0000-0003-0041-9357;
   Ingemansson, Richard/0000-0001-7623-8953
FU Swedish Medical Research Council; Lund University Faculty of Medicine;
   Swedish Government Grant for Clinical Research; Lund University Hospital
   Research Grants; Swedish Medical Association; Royal Physiographic
   Society in Lund; Ake Wiberg Foundation; Anders Otto Sward
   Foundation/Ulrika Eklund Foundation; Magn Bergvall Foundation; Crafoord
   Foundation; Anna-Lisa and Sven-Erik Nilsson Foundation; Jeansson
   Foundation; Swedish Heart-Lung Foundation; Anna and Edvin Berger's
   Foundation; Marta Lundqvist Foundation; Lars Hierta Memorial Foundation
FX We thank Julia Waga for her invaluable assistance with the experimental
   work. This study was supported by the Swedish Medical Research Council,
   Lund University Faculty of Medicine, the Swedish Government Grant for
   Clinical Research, Lund University Hospital Research Grants, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the Ake
   Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika Eklund
   Foundation, the Magn Bergvall Foundation, the Crafoord Foundation, the
   Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeansson Foundation, the
   Swedish Heart-Lung Foundation, Anna and Edvin Berger's Foundation, the
   Marta Lundqvist Foundation, and the Lars Hierta Memorial Foundation.
   Marcom Medical ApS, Denmark, kindly supplied the O2C unit.
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NR 23
TC 47
Z9 56
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV
PY 2011
VL 19
IS 6
BP 727
EP 733
DI 10.1111/j.1524-475X.2011.00741.x
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 840ZK
UT WOS:000296480900009
PM 22092843
DA 2026-07-24
ER
PT J
AU Sziklavari, Z
   Grosser, C
   Neu, R
   Schemm, R
   Kortner, A
   Szöke, T
   Hofmann, HS
AF Sziklavari, Zsolt
   Grosser, Christian
   Neu, Reiner
   Schemm, Rudolf
   Kortner, Ariane
   Szoeke, Tamas
   Hofmann, Hans-Stefan
TI Complex pleural empyema can be safely treated with vacuum-assisted
   closure
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID OPEN WINDOW THORACOSTOMY; THORACIC EMPYEMA; INTRATHORACIC APPLICATION;
   MANAGEMENT; THERAPY; SURGERY
AB Objective: For patients with postoperative pleural empyema, open window thoracostomy (OWT) is often necessary to prevent sepsis. Vacuum-assisted closure (VAC) is a well-known therapeutic option in wound treatment. The efficacy and safety of intrathoracal VAC therapy, especially in patients with pleural empyema with bronchial stump insufficiency or remain lung, has not yet been investigated.
   Methods: Between October 2009 and July 2010, eight consecutive patients (mean age of 66.1 years) with multimorbidity received an OWT with VAC for the treatment of postoperative or recurrent pleural empyema. Two of them had a bronchial stump insufficiency (BPF).
   Results: VAC therapy ensured local control of the empyema and control of sepsis. The continuous suction up to 125 mm Hg cleaned the wound and thoracic cavity and supported the rapid healing. Additionally, installation of a stable vacuum was possible in the two patients with BPF. The smaller bronchus stump fistula closed spontaneously due to the VAC therapy, but the larger remained open.
   The direct contact of the VAC sponge did not create any air leak or bleeding from the lung or the mediastinal structures. The VAC therapy allowed a better re-expansion of remaining lung.
   One patient died in the late postoperative period (day 47 p.o.) of multiorgan failure. In three cases, VAC therapy was continued in an outpatient service, and in four patients, the OWT was treated with conventional wound care. After a mean time of three months, the chest wall was closed in five of seven cases. However, two patients rejected the closure of the OWT. After a follow-up at 7.7 months, neither recurrent pleural empyema nor BPF was observed.
   Conclusion: VAC therapy was effective and safe in the treatment of complicated pleural empyema. The presence of smaller bronchial stump fistula and of residual lung tissue are not a contraindication for VAC therapy.
C1 [Sziklavari, Zsolt; Grosser, Christian; Schemm, Rudolf; Szoeke, Tamas; Hofmann, Hans-Stefan] Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, D-93049 Regensburg, Germany.
   [Neu, Reiner; Kortner, Ariane; Hofmann, Hans-Stefan] Univ Regensburg, Dept Thorac Surg, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Sziklavari, Z (通讯作者)，Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, Prufeningerstr 86, D-93049 Regensburg, Germany.
EM zsolt.sziklavari@barmherzige-regensburg.de
RI Sziklavari, Zsolt/AGI-2440-2022
CR Deslauriers Jean, 2002, Chest Surg Clin N Am, V12, P605, DOI 10.1016/S1052-3359(02)00017-0
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NR 13
TC 22
Z9 40
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD OCT 6
PY 2011
VL 6
AR 130
DI 10.1186/1749-8090-6-130
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 841IZ
UT WOS:000296507300001
PM 21978620
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU de Tullio, D
   Biondin, V
   Occhionorelli, S
AF de Tullio, Damiano
   Biondin, Veronica
   Occhionorelli, Savino
TI When a Postsurgical Dehiscence Becomes a Serious Problem
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative-pressure wound therapy; wounds and dehiscence; spinocerebellar
   ataxia
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; MODEL
AB Therapeutic management of nonhealing wounds is often a challenging condition. Postlaparotomy wound dehiscence can become a serious problem in patients affected with chronic pain and abdomen distension. In this case report, negative-pressure wound therapy with the Chariker-Jeter method was used to treat a dehiscence in a patient affected with type I spinocerebellar ataxia.
C1 [de Tullio, Damiano; Biondin, Veronica] Univ Ferrara, Gen & Thorac Surg Inst, Dept Surg Anesthesiol & Radiol Sci, I-44100 Ferrara, Italy.
   [Occhionorelli, Savino] Univ Ferrara, Surg Clin Inst, Dept Surg Anesthesiol & Radiol Sci, I-44100 Ferrara, Italy.
C3 University of Ferrara; University of Ferrara
RP de Tullio, D (通讯作者)，Emergency & Temporary Observat Dept Vicenza, Vicenza, Italy.
RI ; occhionorelli, savino/AAB-2552-2022
OI de Tullio, Damiano/0000-0002-3419-9789; occhionorelli,
   savino/0000-0001-7799-4320
CR Ahearn C, 2009, OSTOMY WOUND MANAG, V55, P22
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   CHARIKER M E, 1989, Contemporary Surgery, V34, P59
   De Joanna G, 2008, J NEUROL SCI, V275, P60, DOI 10.1016/j.jns.2008.07.015
   França MC, 2007, ARCH NEUROL-CHICAGO, V64, P1767, DOI 10.1001/archneur.64.12.1767
   Heller L, 2006, AM J SURG, V191, P165, DOI 10.1016/j.amjsurg.2005.09.003
   Hess CL, 2003, ANN PLAS SURG, V51, P210, DOI 10.1097/01.SAP.0000058513.10033.6B
   MAKELA JT, 1995, AM J SURG, V170, P387, DOI 10.1016/S0002-9610(99)80309-2
   Malmsjö M, 2009, WOUND REPAIR REGEN, V17, P200, DOI 10.1111/j.1524-475X.2009.00461.x
   Sibbald R Gary, 2003, Ostomy Wound Manage, V49, P52
   Subramonia S, 2009, WORLD J SURG, V33, P931, DOI 10.1007/s00268-009-9947-z
   Thompson JT, 2007, CLIN PLAST SURG, V34, P673, DOI 10.1016/j.cps.2007.07.005
   van Ramshorst GH, 2010, WORLD J SURG, V34, P20, DOI 10.1007/s00268-009-0277-y
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
NR 14
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2011
VL 24
IS 11
BP 503
EP 506
DI 10.1097/01.ASW.0000407646.05209.e2
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 842DN
UT WOS:000296570000003
PM 22015748
DA 2026-07-24
ER
PT J
AU Suissa, D
   Danino, A
   Nikolis, A
AF Suissa, Daniel
   Danino, Alain
   Nikolis, Andreas
TI Negative-Pressure Therapy versus Standard Wound Care: A Meta-Analysis of
   Randomized Trials
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; MANAGEMENT; ULCERS
AB Background: Several randomized controlled trials comparing negative-pressure therapy to standard wound care for chronic wounds have been published. Although these studies suggest a benefit for negative-pressure therapy, the majority of the review articles on the topic conclude that the studies are inconclusive. The authors conducted a quantitative meta-analysis of the effectiveness of negative-pressure therapy for the management of chronic wounds.
   Methods: The MEDLINE, EMBASE, and Cochrane databases were searched from 1993 to March of 2010 for randomized controlled trials comparing negative-pressure therapy to standard wound care for chronic wounds. Measures of wound size and time to healing, along with the corresponding p values, were extracted from the randomized controlled trials. Relative change ratios of wound size and ratios of median time to healing were combined using a random effects model for meta-analysis.
   Results: Ten trials of negative-pressure therapy versus standard wound care were found. In the negative-pressure therapy group, wound size had decreased significantly more than in the standard wound care group (relative change ratio, 0.77; 95 percent confidence interval, 0.63 to 0.96). Time to healing was significantly shorter in the negative-pressure therapy group in comparison with the standard wound care group (ratio of median time to healing, 0.74; 95 percent confidence interval, 0.70 to 0.78).
   Conclusions: This quantitative meta-analysis of randomized trials suggests that negative-pressure therapy appears to be an effective treatment for chronic wounds. An effect of publication bias cannot be ruled out. (Plast. Reconstr. Surg. 128: 498e, 2011.)
C1 [Suissa, Daniel; Danino, Alain; Nikolis, Andreas] Univ Montreal, Div Plast Surg, Hop Notre Dame, Montreal, PQ, Canada.
C3 Universite de Montreal
RP Suissa, D (通讯作者)，840 Car Stewart, Montreal, PQ H4M 2X2, Canada.
EM daniel.suissa@umontreal.ca
RI Nikolis, Andreas/AAZ-4008-2020; danino, alain/E-4103-2012
CR [Anonymous], 2003, ASERNIP-S Report No.37
   Armstrong David G, 2007, Int Wound J, V4, P79, DOI 10.1111/j.1742-481X.2006.00270.x
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Borenstein M, 2009, Introduction to meta-analysis, P421
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Costa V, 2005, 19 MUHC TECHN ASS UN
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Fisher A, NEGATIVE PRESSURE TH
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Frykberg R G, 2000, J Foot Ankle Surg, V39, pS1
   Geddes DM, 2000, Cochrane Database Syst Rev, V5, DOI [DOI 10.1002/14651858.CD002993, 10.1002/14651858.CD002993]
   Gordois A, 2003, DIABETES CARE, V26, P1790, DOI 10.2337/diacare.26.6.1790
   Gregor S, 2008, ARCH SURG-CHICAGO, V143, P189, DOI 10.1001/archsurg.2007.54
   Harding KG, 2002, BMJ-BRIT MED J, V324, P160, DOI 10.1136/bmj.324.7330.160
   HIGGINS S, 2003, EFFECTIVENESS VACUUM
   Joseph E, 2000, WOUNDS, V12, P60
   Kinetic Concepts Inc., VAC CLIN GUID, P69
   Kinetic Concepts Inc., PAG 2 FIN REP 2008, P2
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   McCarthy JE, 2010, PLAST RECONSTR SURG, V126, P1774, DOI 10.1097/PRS.0b013e3181efa201
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Ontario Health Technology Advisory Committee, NEG PRESS WOUND THER
   Peinemann F, 2008, BMC MED RES METHODOL, V8, DOI 10.1186/1471-2288-8-4
   Pompeo M Q, 2001, Ostomy Wound Manage, V47, P65
   Samson D, AGENCY HLTH CARE RES
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   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
NR 30
TC 80
Z9 95
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2011
VL 128
IS 5
BP 498E
EP 503E
DI 10.1097/PRS.0b013e31822b675c
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 842GQ
UT WOS:000296583600013
PM 22030509
DA 2026-07-24
ER
PT J
AU Jordana, M
   Pint, E
   Martens, A
AF Jordana, M.
   Pint, E.
   Martens, A.
TI The use of vacuum-assisted wound closure to enhance skin graft
   acceptance in a horse
SO VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
LA English
DT Article
ID MANAGEMENT
AB A 16-year-old horse was admitted to the clinic of the Department of Surgery and Anesthesiology of Domestic Animals of the Faculty of Veterinary Medicine (Ghent University) for the treatment of a very large, non-healing wound extending over the dorsomedial and dorsolateral aspects of the left metatarsus. Surgical debridement of exuberant granulation tissue and new bone was performed under general anesthesia, followed by standard wound care under a bandage. Once a new bed of healthy granulation had formed, skin grafting was performed using the punch graft method. Due to the presence of a significant amount of wound exudate, cast immobilization was considered to be contraindicated. Instead, vacuum-assisted closure (VAC) therapy was used as a method of securing the skin grafts to the wound bed during the first days post-operatively. After five days of VAC therapy, the wound dressing was removed and an acceptance of nearly 100% of the punch grafts was observed. Complete epithelialization of the wound was evident 42 days after skin grafting. As far as the authors know, this is the first report describing the use of VAC therapy as a method of wound management in combination with punch grafting on the distal limb of a horse.
C1 [Jordana, M.; Pint, E.; Martens, A.] Univ Ghent, Dept Surg & Anesthesiol Domest Anim, Fac Vet Med, B-9820 Merelbeke, Belgium.
C3 Ghent University
RP Jordana, M (通讯作者)，Univ Ghent, Dept Surg & Anesthesiol Domest Anim, Fac Vet Med, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM mireia.jordanagarcia@ugent.be
RI ; Jordana, Mireia/AAD-8980-2022
OI Martens, Ann/0000-0001-9554-4841; 
CR Gemeinhardt KD, 2005, EQUINE VET EDUC, V17, P27, DOI 10.1111/j.2042-3292.2005.tb00331.x
   Hanson R. R., 2008, EQUINE WOUND MANAGEM, P427
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   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Perrin R., 2011, Pratique Veterinaire Equine, V43, P41
   Rijkenhuizen ABM, 2005, PFERDEHEILKUNDE, V21, P413, DOI 10.21836/PEM20050503
   Schumacher J., 2008, EQUINE WOUND MANAGEM, V2nd, P509
   Schumacher J., 2006, EQUINE SURG, P269, DOI 10.1016/B1-41-600123-9/50027-9
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   Wilmink JM, 2006, EQUINE VET J, V38, P324, DOI 10.2746/042516406777749290
   Wilson DA, 2008, EQUINE WOUND MANAGEM, P225
NR 16
TC 17
Z9 18
U1 1
U2 30
PU UNIV GHENT
PI GHENT
PA FACULTY VETERINARY MEDICINE, B-9000 GHENT, BELGIUM
SN 0303-9021
J9 VLAAMS DIERGEN TIJDS
JI Vlaams Diergeneeskd. Tijdschr.
PD SEP-OCT
PY 2011
VL 80
IS 5
BP 343
EP 350
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 842JS
UT WOS:000296596100004
DA 2026-07-24
ER
PT J
AU Ulusal, AE
   Sahin, MS
   Ulusal, B
   Çakmak, G
   Tuncay, C
AF Ulusal, Ali Engin
   Sahin, M. Sukru
   Ulusal, Betul
   Cakmak, Gokhan
   Tuncay, Cengiz
TI Negative pressure wound therapy in patients with diabetic foot
SO ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
LA English
DT Article
DE Amputation; diabetes, negative pressure wound therapy; wound
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; DRESSINGS
AB Objective: In this study our aim was to compare the results of standard dressing treatment to negative pressure wound therapy (NPWT) performed with a vacuum-assisted closure (VAC) device in patients with diabetic foot ulcers.
   Methods: We assessed the results of 35 patients treated for diabetic foot ulcer between 2006 and 2008. Of these cases, 20 (4 women and 16 men; mean age: 66 years; range: 52-90 years) were treated with standard wet dressings and 16 feet in 15 patients (10 men, 5 women; mean age: 58.9 years; range: 42-83 years) with VAC therapy. The success of treatment was evaluated in terms of hospitalization length and rate of limb salvation.
   Results: The average hospitalization period with VAC treatment was 32 days compared to 59 days with standard dressing treatment. All patients treated with standard dressings eventually had to undergo amputation. However, the amputation rate was 37% in the VAC treated group and 88% of patients had a functional extremity at the end of treatment.
   Conclusion: VAC therapy, together with debridement and appropriate antibiotic therapy, enables a higher rate of limb salvage, especially in Wagner Grade 3 and Grade 4 ulcers.
C1 [Ulusal, Ali Engin] Balikesir Univ, Fac Med, Dept Orthopaed & Traumatol, Balikesir, Turkey.
   [Sahin, M. Sukru; Cakmak, Gokhan; Tuncay, Cengiz] Baskent Univ, Fac Med, Dept Orthopaed & Traumatol, TR-06490 Ankara, Turkey.
   [Ulusal, Betul] Balikesir Univ, Fac Med, Dept Plast & Reconstruct Surg, Balikesir, Turkey.
C3 Balikesir University; Baskent University; Balikesir University
RP Ulusal, AE (通讯作者)，Balikesir Univ Tip Fak, Ortopedi & Travmatol Anabilim Dali, Cagis Kampusu, Balikesir, Turkey.
EM aeulusal@gmail.com
RI Cakmak, Gokhan/AFU-9202-2022; tuncay, ismail cengiz/AAF-3988-2021;
   Sahin, Mehmet Sukru/AAJ-9972-2021
OI Cakmak, Gokhan/0000-0002-7230-2871; tuncay, ismail
   cengiz/0000-0001-5856-8895; Sahin, Mehmet Sukru/0000-0001-7677-8423
CR ANDREW JM, 2001, LEVIN ONEALS DIABETI, P261
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Brem H, 2006, PLAST RECONSTR SURG, V117, p193S, DOI 10.1097/01.prs.0000225459.93750.29
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
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NR 17
TC 27
Z9 36
U1 0
U2 22
PU TURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY
PI ISTANBUL
PA SEHREMINI MAH KOYUNCU SK CIGDEM APT NO 4 D 5 FATIH, ISTANBUL, 00000,
   TURKEY
SN 1017-995X
J9 ACTA ORTHOP TRAUMATO
JI Acta Orthop. Traumatol. Turc.
PD JUL-AUG
PY 2011
VL 45
IS 4
BP 254
EP 260
DI 10.3944/AOTT.2011.2283
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 843GS
UT WOS:000296660900009
PM 21908965
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Mayer, D
   Hasse, B
   Koelliker, J
   Enzler, M
   Veith, FJ
   Rancic, Z
   Lachat, M
AF Mayer, Dieter
   Hasse, Barbara
   Koelliker, Jeannette
   Enzler, Markus
   Veith, Frank J.
   Rancic, Zoran
   Lachat, Mario
TI Long-Term Results of Vascular Graft and Artery Preserving Treatment With
   Negative Pressure Wound Therapy in Szilagyi Grade III Infections Justify
   a Paradigm Shift
SO ANNALS OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAP COVERAGE; CURRENT OPTIONS; GROIN;
   EXPERIENCE; PRESERVATION; MANAGEMENT; SURGERY; BYPASS; TRIAL
AB Objective: To present the first long-term results of Szilagyi III vascular infections treated by negative pressure wound therapy (NPWT) with graft preservation.
   Background Data: Szilagyi III infections are usually treated by graft/artery excision and secondary vascular/plastic reconstruction. Small series treated with NPWT without graft removal are reported with good short-term to midterm results.
   Methods: The outcomes of 44 polymorbid patients (mean age = 62 years) with Szilagyi III infections from 2002 to 2009 were analyzed. Thirteen of forty-four required intensive care unit treatment. Forty grafts (prosthetic = 24, vein = 3, biological = 13) and 9 native arteries were involved. Negative pressure wound therapy (VAC; KCI International, Amstelveen, Netherlands) was applied directly on grafts/arteries (negative pressure = 50-125 mm Hg) after radical debridement of infected tissue. Antibiotic treatment was initiated and adapted according to microbiology.
   Results: Median duration of NPWT was 33 days (IQR: 20-78), of hospital stay 32 (IQR: 20-82) days. All patients survived 30 days. One-year mortality was 16% (7/44). Long-term mortality after a mean follow-up of 43 months (SD: 21) was 41% (18/44).
   Complete wound healing was achieved in 91% (40/44). In 37 of 44 patients, grafts were preserved long-term without reinfection. There was no statistically significant difference in outcome between the various graft types involved.
   Conclusions: Vascular graft/arterial preserving treatment with NPWT in Szilagyi III infections was safe and effective with a very low short-term mortality. The majority of infected grafts were preserved without reinfection during a mean long-term follow-up of 4 years. This new treatment algorithm avoids major reconstructive surgery and should be used when dealing with Szilagyi III vascular infections.
C1 [Mayer, Dieter; Koelliker, Jeannette; Veith, Frank J.; Rancic, Zoran; Lachat, Mario] Univ Zurich Hosp, Cardiovasc Surg Clin, CH-8091 Zurich, CH, Switzerland.
   [Hasse, Barbara] Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, CH-8091 Zurich, CH, Switzerland.
   [Enzler, Markus] Vasc Ctr Hirslanden, Zurich, CH, Switzerland.
   [Veith, Frank J.] Cleveland Clin, New York, NY USA.
   [Veith, Frank J.] NYU Med Ctr, New York, NY 10016 USA.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital; Cleveland Clinic Foundation; New York
   University
RP Mayer, D (通讯作者)，Univ Zurich Hosp, Cardiovasc Surg Clin, Raemistr 100, CH-8091 Zurich, CH, Switzerland.
EM dieter.mayer@usz.ch
RI Lachat, Mario/G-4826-2011; Mayer, Dieter/E-7617-2011; Hasse,
   Barbara/T-1054-2017
OI Lachat, Mario/0000-0001-7812-2110; Mayer, Dieter/0000-0001-5933-7749;
   Hasse, Barbara/0000-0001-7196-3734
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NR 51
TC 54
Z9 60
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0003-4932
J9 ANN SURG
JI Ann. Surg.
PD NOV
PY 2011
VL 254
IS 5
BP 754
EP 760
DI 10.1097/SLA.0b013e3182365864
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 844IK
UT WOS:000296740700011
PM 21997817
DA 2026-07-24
ER
PT J
AU Wagner, S
   Greco, F
   Hoda, MR
   Kawan, F
   Heynemann, H
   Fornara, P
AF Wagner, Sigrid
   Greco, Francesco
   Hoda, M. Raschid
   Kawan, Felix
   Heynemann, Hans
   Fornara, Paolo
TI Is Intensive Multimodality Therapy the Best Treatment for Fournier
   Gangrene? Evaluation of Clinical Outcome and Survival Rate of 41
   Patients
SO SURGICAL INFECTIONS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; NECROTIZING FASCIITIS; HYPERBARIC-OXYGEN;
   SEVERITY INDEX; RISK-FACTORS; STRATEGIES
AB Background: To evaluate the effect of surgical wound debridement, antibiotics, and hyperbaric oxygen (HBO) in the treatment of Fournier gangrene (FG).
   Methods: Forty-one patients with a mean age of 54.3 +/- 14.6 years were referred to our department with a diagnosis of FG. To calculate a Fourier Gangrene Severity Index (FGSI), nine factors were assessed (temperature; heart rate; ventilatory rate; serum sodium, potassium, creatinine, and bicarbonate concentrations; hematocrit; and leukocyte count). After clinical stabilization, extensive debridement of the necrotic tissue was performed, and a surgical vacuum-assisted closure (V. A. C.(R)) device was applied. Hyperbaric oxygen was administered; medical therapy consisted of intravenous antibiotics, electrolyte replacement, and parenteral nutrition.
   Results: Intraoperative cultures revealed Escherichia coli in 27 patients (66%), Pseudomonas aeruginosa in 28 (68%), gram-positive cocci in 24 (59%), and mixed flora (aerobic and anaerobic bacteria) in 39 (95%). One month after primary debridement, wound granulation was sufficient for plastic surgical reconstruction in all patients.
   Conclusion: Because of the rapid worsening of FG, early diagnosis and immediate, aggressive multi-modality therapy with surgical debridement and broad-spectrum empiric antibiotics is crucial. The utility of HBO remains unproved.
C1 [Greco, Francesco] Univ Halle Wittenberg, Urol Clin, Dept Urol & Kidney Transplantat, D-06120 Halle, Germany.
C3 Martin Luther University Halle Wittenberg
RP Greco, F (通讯作者)，Univ Halle Wittenberg, Urol Clin, Dept Urol & Kidney Transplantat, Ernst Grube Str 40, D-06120 Halle, Germany.
EM francesco.greco@medizin.uni-halle.de
RI Greco, Francesco/GPK-1147-2022
OI Greco, Francesco/0000-0002-9466-3029
CR [Anonymous], 1883, SEMIN MED
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NR 22
TC 10
Z9 12
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD OCT
PY 2011
VL 12
IS 5
BP 379
EP 383
DI 10.1089/sur.2010.091
PG 5
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA 846MB
UT WOS:000296905900009
PM 21943303
DA 2026-07-24
ER
PT J
AU Taylor, CJ
   Chester, DL
   Jeffery, SL
AF Taylor, Christopher J.
   Chester, Darren L.
   Jeffery, Steven L.
TI Functional Splinting of Upper Limb Injuries With Gauze-Based Topical
   Negative Pressure Wound Therapy
SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME
LA English
DT Article
DE Functional splinting; hand injury; topical negative pressure;
   war-related injury
ID RECONSTRUCTION
AB Complex hand injuries can be difficult to dress effectively and achieve adequate splintage of the hand in a functional position. During the past 7 years, we have had a great deal of success with topical negative-pressure dressings in the management of complex blast-related extremity war injuries. We have more recently changed to using a gauze-based system and have found this particularly useful in dressing complex hand injuries. We have been able to use this vacuum dressing system to splint the hand in a position of function. This provides an easily applied dressing that, through topical negative pressure, promotes wound healing and ensures a resting functional position, thus minimizing postoperative stiffness. We have not been able to achieve this as efficiently with standard dressings and plaster-of-Paris casts. This article details the technique of functional splinting of complex hand injuries using a gauze-based, topical negative-pressure dressing system. (J Hand Surg 2011;36A:1848-1851. (C) 2011 Published by Elsevier Inc. on behalf of the American Society for Surgery of the Hand.)
C1 [Taylor, Christopher J.; Chester, Darren L.; Jeffery, Steven L.] Queen Elizabeth Hosp, Birmingham B15 2TH, W Midlands, England.
C3 University of Birmingham
RP Taylor, CJ (通讯作者)，New Queen Elizabeth Hosp, Dept Reconstruct Plast Surg, Mindelsohn Way, Birmingham B15 2WB, W Midlands, England.
EM christaylor@doctors.org.uk
RI jeffery, steven/A-5207-2013
OI jeffery, steven/0000-0001-6587-5412
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NR 13
TC 12
Z9 13
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0363-5023
J9 J HAND SURG-AM
JI J. Hand Surg.-Am. Vol.
PD NOV
PY 2011
VL 36A
IS 11
BP 1848
EP 1851
DI 10.1016/j.jhsa.2011.08.023
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 846TR
UT WOS:000296926600019
PM 22036283
DA 2026-07-24
ER
PT J
AU Agha, R
   Ogawa, R
   Pietramaggiori, G
   Orgill, DP
AF Agha, Riaz
   Ogawa, Rei
   Pietramaggiori, Giorgio
   Orgill, Dennis P.
TI A Review of the Role of Mechanical Forces in Cutaneous Wound Healing
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Review
DE cutaneous; wound healing; micromechanical forces; angiogenesis; VAC;
   keloid hypertrophic scarring; wound tension
ID VACUUM-ASSISTED CLOSURE; RED DUROC PIG; HYPERTROPHIC SCAR FORMATION;
   SMOOTH-MUSCLE-CELLS; SILICONE GEL SHEETS; SKIN WOUNDS; IN-VITRO;
   EXTRACELLULAR-MATRIX; HEMODYNAMIC FORCES; VASCULAR-RESPONSES
AB Cutaneous wound healing is a complex process with many types of mechanical forces regulating the quality and speed of healing. The role of mechanical forces in regulating tissue growth, repair and remodelling was recognised more than a century ago. Such forces influence gene expression, the synthesis of growth factors and inflammatory mediators and cellular processes like proliferation of many load-sensitive cells. However, the exact mechanisms by which these forces interact with cells and ways to use them to stimulate tissues are still active research fronts. This article sets to review the literature on mechanical forces and their role in cutaneous wound healing. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Agha, Riaz] Cambridge Univ Hosp NHS Fdn Trust, Dept Vasc Surg, Natl Inst Hlth & Clin Excellence Scholar, Cambridge, England.
   [Ogawa, Rei] Nippon Med Sch, Bunkyo Ku, Tokyo 113, Japan.
   [Pietramaggiori, Giorgio] Univ Geneva, Div Plast Surg, Geneva, Switzerland.
   [Orgill, Dennis P.] Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA 02115 USA.
   [Orgill, Dennis P.] Harvard Univ, Sch Med, Boston, MA USA.
C3 National Institute for Health & Care Excellence; University of
   Cambridge; Nippon Medical School; University of Geneva; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard Medical School
RP Agha, R (通讯作者)，Queen Victoria Hosp NHS Fdn Trust, Dept Plast Surg, Holtye Rd, E Grinstead RH19 3DZ, W Sussex, England.
EM mail@riazagha.com
RI Agha, Riaz/KLC-2726-2024; Orgill, Dennis/H-7596-2019; PIETRAMAGGIORI,
   Giorgio/HJA-1920-2022
OI Agha, Riaz/0000-0002-9348-0095; Orgill, Dennis/0000-0002-8279-7310; 
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NR 124
TC 136
Z9 170
U1 1
U2 86
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD DEC
PY 2011
VL 171
IS 2
BP 700
EP 708
DI 10.1016/j.jss.2011.07.007
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 847FS
UT WOS:000296957900063
PM 22005503
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Ingemansson, R
AF Malmsjo, Malin
   Ingemansson, Richard
TI Effects of green foam, black foam and gauze on contraction, blood flow
   and pressure delivery to the wound bed in negative pressure wound
   therapy
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Experimental surgery; Wound healing; Negative pressure; wound therapy;
   Wound contraction; Blood flow; Wound dressing
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; MATRIX
   METALLOPROTEINASES
AB Background: Negative pressure wound therapy (NPWT) contracts the wound and alters the microvascular blood flow in the wound edge, which may be crucial in promoting wound healing. The aim of the present study was to examine these biological effects in the wound edge using different types of wound fillers.
   Methods: Wounds were created on the backs of pigs and filled with green foam, black foam or gauze. Dressings for NPWT were then applied. The immediate effects of continuous NPWT, including pressure transmission to the wound bed and microvascular blood flow (using laser Doppler velocimetry), were studied in eight pigs that were anaesthetised for 12 h. In another eight pigs, wound contraction was studied during 72 h of NPWT.
   Results: Pressure transduction to the wound bed was similar through green foam, black foam and gauze, with only small pressure drop. Wound contraction was more pronounced for green and black foam than for gauze. Blood flow was found to decrease 0.5 cm from the wound edge and increase 2.5 cm from the wound edge. The increase in blood flow was similar with all wound fillers, while the decrease was less pronounced with gauze than with both foams.
   Conclusions: The biological effects of NPWT depend on the type of wound filler. Green and black foam have similar effects, while gauze results in less pronounced wound contraction and hypoperfusion. NPWT may be tailored to the individual wound type to optimise the effects and minimise the complications by choosing different wound fillers. (C) 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Malmsjo, Malin; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599
FU Molnlycke Health Care AB
FX Molnlycke Health Care AB.
CR ANESATER E, 2011, INT WOUND J
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NR 37
TC 16
Z9 19
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2011
VL 64
IS 12
BP E289
EP E296
DI 10.1016/j.bjps.2011.06.023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 847GC
UT WOS:000296959000001
PM 21788163
DA 2026-07-24
ER
PT J
AU Karatepe, O
   Eken, I
   Acet, E
   Unal, O
   Mert, M
   Koc, B
   Karahan, S
   Filizcan, U
   Ugurlucan, M
   Aksoy, M
AF Karatepe, O.
   Eken, I.
   Acet, E.
   Unal, O.
   Mert, M.
   Koc, B.
   Karahan, S.
   Filizcan, U.
   Ugurlucan, M.
   Aksoy, M.
TI Vacuum Assisted Closure Improves the Quality of Life in Patients with
   Diabetic Foot
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
ID EPIDEMIOLOGY; INFECTIONS; PREVALENCE
AB Background : Diabetes Mellitus (DM) is the most common endocrine disease worldwide. One of the most important chronic complications of this disease is the development of diabetic foot. The management of diabetic foot wounds is quite important with respect to public health.
   Aims : To determine the effect of Vacuum Assisted Closure (VAC) therapy on the quality of life in the treatment of diabetic foot ulcers and compare it with standart wound care.
   Methods : Between May 2007 to December 2008, 67 consecutive patients with diabetic foot ulcers were randomly assigned to VAC therapy (Group1, n : 30) or standart wound care (Group 2, n : 37). The SF-36 questionnaire was administered the day before and in the month following wound healing. Global analyses of the 8 domains and 2 comprehensive indexes of SF-36, Physical Component Summary (PCS) and Mental Component Summary (MCS) were performed.
   Clinical measures included standard antidiabetic treatment, daily wound care including antiseptic bath, debridement, toe removal for gangrene when necessary, and wound care with conventional methods or VAC. Healing time was calculated as the time from hospital admission to the time of re-epithelization.
   Results : There were no differences in the mean age, ulcer size and pulse status of the patients in both groups. Healing time in the VAC group was significantly reduced (p < 0.05). All 8 domains of SF-36 and MCS and PCS scores improved remarkably after VAC therapy.
   Conclusion : Vacuum Assited Closure therapy was found to be effective in the treatment of chronic diabetic ulcers. The improvement of quality of life demonstrates a clear-cut indication in this particular group of patients.
C1 [Karatepe, O.; Eken, I.; Acet, E.; Koc, B.; Karahan, S.] Okmeydani Training & Res Hosp, Dept Gen Surg, TR-34715 Istanbul, Turkey.
   [Unal, O.] Okmeydani Training & Res Hosp, Dept Vasc Surg, TR-34715 Istanbul, Turkey.
   [Mert, M.] Okmeydani Training & Res Hosp, Dept Endocrinol, TR-34715 Istanbul, Turkey.
   [Filizcan, U.] Maltepe Univ, Fac Med, Dept Cardiovasc Surg, Maltepe, Turkey.
   [Ugurlucan, M.] Duzce Ataturk State Hosp, Dept Cardiovasc Surg, Duzce, Turkey.
   [Aksoy, M.] Istanbul Univ, Fac Med, Dept Gen Surg, Istanbul, Turkey.
C3 Istanbul Okmeydani Training & Research Hospital; Istanbul Okmeydani
   Training & Research Hospital; Istanbul Okmeydani Training & Research
   Hospital; Maltepe University; Duzce Ataturk State Hospital; Istanbul
   University
RP Karatepe, O (通讯作者)，Okmeydani Training & Res Hosp, Dept Gen Surg, TR-34715 Istanbul, Turkey.
EM muratugurlucan@yahoo.com
RI ; Unal, Orcun/HJG-7654-2022
OI FILIZCAN, UGUR/0000-0001-5427-550X; Aksoy, Murat/0000-0002-9116-3985;
   Unal, Orcun/0000-0003-1859-8533
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NR 17
TC 47
Z9 49
U1 0
U2 23
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD SEP-OCT
PY 2011
VL 111
IS 5
BP 298
EP 302
DI 10.1080/00015458.2011.11680757
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 847WM
UT WOS:000297003200006
PM 22191131
DA 2026-07-24
ER
PT J
AU Meeker, J
   Weinhold, P
   Dahners, L
AF Meeker, James
   Weinhold, Paul
   Dahners, Laurence
TI Negative Pressure Therapy on Primarily Closed Wounds Improves Wound
   Healing Parameters at 3 Days in a Porcine Model
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE wound healing; negative pressure therapy; closed wounds
ID VACUUM-ASSISTED CLOSURE; DRAINAGE
AB Objectives: We investigated the role of negative pressure therapy (NPT) in postoperative primary wound treatment and closure. To date, extensive evidence exists demonstrating the benefit of negative pressure dressings in the treatment of open wounds; our experiment tested the hypothesis that negative pressure dressings improve healing of closed (sutured) wounds.
   Methods: A porcine model was used to collect data on the characteristics of closed wounds after 3 days of treatment with NPTs as compared with control dressings.
   Results: In six pigs with a total of 56 wounds, load to failure (N/mm) in controls was 0.348 (standard deviation [SD] 0.109) versus NPT at 0.470 (SD, 0.194) with a P value of 0.001; energy to failure (mJ/mm) in controls was 0.85 (SD, 0.378) versus NPT at 1.128 (SD, 0.638) with a P value of 0.035. Blinded grading of clinical wound appearance and cross-sectional hematoma size were also improved at 72 hours.
   Conclusions: NPT dressings applied to surgically closed wounds enhance the healing characteristics of porcine wounds at 3 days.
   Clinical Relevance: We have observed that primarily closed surgical wounds may benefit from treatment with NPT. The benefit of using NPTs may be most pronounced in situations in which wounds are closed under tension, involve considerable soft tissue trauma, or may be at risk of subdermal hematoma formation.
C1 [Meeker, James; Weinhold, Paul; Dahners, Laurence] Univ N Carolina, Dept Orthopaed, Sch Med, Chapel Hill, NC 27599 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine
RP Meeker, J (通讯作者)，Univ N Carolina, Dept Orthopaed, Sch Med, CB 7055, Chapel Hill, NC 27599 USA.
EM jmeeker@unch.unc.edu
OI Weinhold, Paul/0000-0002-7307-3580
FU Orthopaedic Trauma Association
FX The study was funded entirely with a $10,000 Resident Research Grant
   from the Orthopaedic Trauma Association.
CR Ashraf T, 2001, ORTHOPEDICS, V24, P1158
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NR 14
TC 38
Z9 45
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD DEC
PY 2011
VL 25
IS 12
BP 756
EP 761
DI 10.1097/BOT.0b013e318211363a
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 850OY
UT WOS:000297206200011
PM 22089760
DA 2026-07-24
ER
PT J
AU Yoshida, S
   Yokoyama, R
   Sakamoto, A
AF Yoshida, Sei
   Yokoyama, Ryohei
   Sakamoto, Akio
TI TREATMENT OF PELVIC DEFECT AND INFECTION WITH ENDOPROSTHESIS EXPOSURE BY
   TOPICAL NEGATIVE PRESSURE AND IRRIGATION WITH MYOCUTANEOUS FLAP
SO MICROSURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; RECONSTRUCTION
AB The treatment of wound complications and deep infection after hemipelvectomy is challenging. We describe a 17-year-old woman with Ewing sarcoma in the pelvis who underwent hemipelvectomy and reconstruction with an artificial hip joint and bone cement. After the operation, skin necrosis and deep infection with methicillin-resistant Staphylococcus aureus (MRSA) were observed. Debridement resulted in exposure of the artificial joint and bone cement. Topical negative pressure (TNP) and irrigation successfully eradicated the infection. The skin and soft-tissue defect was subsequently reconstructed using a combination of free latissimus dorsi myocutaneous flap and serratus anterior muscle flap. To our knowledge, this is the first described case of combined TNP and irrigation with myocutaneous flap for the treatment of pelvic infection and skin and soft-tissue defect with endoprosthesis exposure. (C) 2011 Wiley Periodicals, Inc. Microsurgery 31: 655-658, 2011.
C1 [Sakamoto, Akio] Kyushu Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Higashi Ku, Fukuoka 8128582, Japan.
   [Yoshida, Sei] Natl Hosp Org, Kyushu Canc Ctr, Dept Plast Surg, Fukuoka, Japan.
   [Yokoyama, Ryohei] Natl Hosp Org, Kyushu Canc Ctr, Dept Orthopaed Surg, Fukuoka, Japan.
C3 Kyushu University; Kyushu Cancer Center; Kyushu Cancer Center
RP Sakamoto, A (通讯作者)，Kyushu Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM akio@med.kyushu-u.ac.jp
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NR 16
TC 6
Z9 7
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0738-1085
J9 MICROSURG
JI Microsurgery
PD NOV
PY 2011
VL 31
IS 8
BP 655
EP 658
DI 10.1002/micr.20932
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 851PN
UT WOS:000297283400011
PM 21919051
DA 2026-07-24
ER
PT J
AU Tuncer, S
   Karaca, S
AF Tuncer, Serdar
   Karaca, Sinan
TI Muscle Transposition and Circumferential Vacuum-Assisted Closure to
   Salvage the Knee Joint in Transtibial Amputation of the Leg: Case Report
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE degloving injury; lower extremity; amputation; vacuum assisted closure;
   skin grafting
ID STUMPS
AB Degloving injury is the avulsion of the skin off the underlying muscle and bone, which may also involve the latter structures in high-energy trauma. This study reports the case of a 33-year-old male patient who sustained a motorcycle accident and presented with hypovolemic shock, multiple fractures, and multiplanar degloving injury of the leg. The foot and distal leg was not salvageable, and a transtibial amputation with anterior tranposition of the posterior compartment muscles was performed; however, a circumferential skin necrosis involving the stump and the knee joint occurred. The wound granulated rapidly using circumferential vacuum-assisted closure therapy and subsequently repaired with split thickness skin grafts. The authors found the topical negative pressure using the Vacuum Assisted Closure (VAC) technique Trademark KCI, Texas, USA, method to be helpful in the care of lower extremity degloving injury, enabling less frequent dressing changes and facilitating formation of granulation tissue with rapid preparation of the wound bed for salvage of the knee joint.
C1 [Tuncer, Serdar; Karaca, Sinan] Istanbul Bilim Univ, Istanbul, Turkey.
C3 Demiroglu Bilim University
RP Tuncer, S (通讯作者)，Kocamansur Sok 104-4 Zarif Apt Sisli, Istanbul, Turkey.
EM serdartuncer@hotmail.com
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   Parry IS, 2008, J BURN CARE RES, V29, P949, DOI 10.1097/BCR.0b013e31818b9ee7
   Shilt JS, 2004, J PEDIATR ORTHOPED, V24, P482, DOI 10.1097/01241398-200409000-00006
   Thompson TC, 1944, J BONE JOINT SURG, V26, P639
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NR 9
TC 2
Z9 3
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD JUN
PY 2011
VL 10
IS 2
BP 93
EP 95
DI 10.1177/1534734611409370
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 851VV
UT WOS:000297300400007
PM 21693444
DA 2026-07-24
ER
PT J
AU Younan, GJ
   Heit, YI
   Dastouri, P
   Kekhia, H
   Xing, W
   Gurish, MF
   Orgill, DP
AF Younan, George J.
   Heit, Yvonne I.
   Dastouri, Pouya
   Kekhia, Hussein
   Xing, Wei
   Gurish, Michael F.
   Orgill, Dennis P.
TI Mast Cells Are Required in the Proliferation and Remodeling Phases of
   Microdeformational Wound Therapy
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; IMMUNE CELLS; INFLAMMATION; MATRIX; TISSUE;
   INVOLVEMENT; CHYMASE; DEVICE
AB Background: Mast cells are important in numerous inflammatory processes. They are also mechanosensitive and likely play an important role in wound healing. The authors hypothesized that mechanical alteration of the wound environment with a distributed suction device could link mast cells to the healing cascade.
   Methods: Controlled uniform full-thickness wound surface microdeformations were induced by suction combined with an open-pore polyurethane foam (microdeformational wound therapy) in mast cell-deficient WWv mice and their mast cell-sufficient littermates. Wound healing parameters were assessed in the inflammatory, proliferative, and remodeling phases of healing.
   Results: Wound tissue granulation, cell proliferation, blood vessel sprouting, and collagen maturation were found to be mast cell-dependent throughout the proliferating and remodeling stages of healing.
   Conclusion: Mast cells are critical in the robust granulation tissue response seen in microdeformational wound therapy and in the modulation of the remodeling phase of wound healing. (Plast. Reconstr. Surg. 128: 649e, 2011.)
C1 [Orgill, Dennis P.] Harvard Univ, Div Plast Surg, Brigham & Womens Hosp, Dept Radiol,Med Sch, Boston, MA 02115 USA.
   Harvard Univ, Dept Med, Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy,Med Sch, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital
RP Orgill, DP (通讯作者)，Harvard Univ, Div Plast Surg, Brigham & Womens Hosp, Dept Radiol,Med Sch, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI ; Orgill, Dennis/H-7596-2019
OI Younan, George/0000-0001-8502-4850; Orgill, Dennis/0000-0002-8279-7310
FU KCI; National Institutes of Health [GM 052585]
FX Dr. Orgill is the principal investigator on research grants to the
   Brigham and Women's Hospital by, and is also an expert witness for,
   Kinetic Concepts, Inc., San Antonio, Texas. This study was not funded by
   KCI. Dr. Gurish has received research support from National Institutes
   of Health grant GM 052585. The other authors have no financial interests
   to declare.
CR [Anonymous], PLAST RECONSTR SURG
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NR 38
TC 54
Z9 62
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2011
VL 128
IS 6
BP 649E
EP 658E
DI 10.1097/PRS.0b013e318230c55d
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 852DU
UT WOS:000297329700012
PM 22094766
DA 2026-07-24
ER
PT J
AU Ozer, MT
   Coskun, AK
   Ozerhan, IH
   Ersoz, N
   Yildiz, R
   Sinan, H
   Demirbas, S
   Kozak, O
   Uzar, AI
   Cetiner, S
AF Ozer, Mustafa Tahir
   Coskun, Ali Kagan
   Ozerhan, Ismail Hakki
   Ersoz, Nail
   Yildiz, Ramazan
   Sinan, Huseyin
   Demirbas, Sezai
   Kozak, Orhan
   Uzar, Ali Ihsan
   Cetiner, Sadettin
TI Use of vacuum-assisted closure (VAC™) in high-energy complicated
   perineal injuries: analysis of nine cases
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE High-energy perineal trauma; Vacuum-assisted closure; Wound care
ID OPEN PELVIC FRACTURES; SOFT-TISSUE INJURIES; WOUND CONTROL; MANAGEMENT;
   THERAPY; TRAUMA
AB Our study reviewed nine patients who were treated with the VAC (TM) Abdominal Dressing System after suffering pelvic fractures and soft tissue loss after high-energy pelvic trauma. Between March 2008 and August 2009, our clinic treated nine patients with complicated perineal injuries from high-energy pelvic trauma with multiple irrigation and debridement procedures and broad-spectrum antibiotics. Protective ostomies were created for all nine patients. Required interventions were made for associated injuries, and VAC (TM) application was started. All patients were male, with an average age of 24.3 (range 21-32) years, and a mean injury severity score of 36.4 (range 16-59). Wound diameters ranged from 15 to 30 cm, and wound depths ranged from 5 to 25 cm. The injuries included one traumatic bilateral hemipelvectomy, and three unilateral and two bilateral lower extremity amputations. Intensive care unit length of stay averaged 12 (6-19) days, and average hospital length of stay was 44.12 (31-64) days. Beginning at an average of day 17 (+/- 5.9 days) post-injury, wound cultures detected no bacterial colonisation. One patient died on the sixth day after injury from septic complications. Two patients' wounds were closed by primary closure, and six patients' wounds were closed by split thickness grafts after an average of 31.4 (17-50) days. Optimal treatment of high-energy perineal injuries requires early and extensive debridement and rich irrigation. The application of the VAC (TM) system as temporary coverage of large complex wounds in the pelvic region enhances wound healing and facilitates an early grafting process.
C1 [Ozer, Mustafa Tahir; Coskun, Ali Kagan; Ozerhan, Ismail Hakki; Ersoz, Nail; Yildiz, Ramazan; Sinan, Huseyin; Demirbas, Sezai; Kozak, Orhan; Uzar, Ali Ihsan; Cetiner, Sadettin] Gulhane Mil Med Acad, Dept Gen Surg, TR-06018 Ankara, Etlik, Turkey.
C3 Gulhane Training & Research Hospital
RP Sinan, H (通讯作者)，Gulhane Mil Med Acad, Dept Gen Surg, TR-06018 Ankara, Etlik, Turkey.
EM hsinan@gata.edu.tr
RI /J-2289-2015; OZERHAN, ISMAIL HAKKI/H-8689-2012; /ACE-3488-2022;
   /O-2379-2014; yıldız, ramazan/HFZ-9568-2022; özerhan, ismail
   hakkı/H-8689-2012
OI OZERHAN, ISMAIL HAKKI/0000-0001-7142-9793; UZAR, Ali
   İhsan/0000-0003-0889-1496; Kozak, Orhan/0000-0002-7302-1203; özerhan,
   ismail hakkı/0000-0001-5777-8671
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NR 21
TC 9
Z9 21
U1 0
U2 11
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2011
VL 8
IS 6
BP 599
EP 607
DI 10.1111/j.1742-481X.2011.00835.x
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 854AL
UT WOS:000297466800006
PM 21854547
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Richards, AJ
   Hagelstein, SM
   Patel, GK
   Ivins, NM
   Sweetland, HM
   Harding, KG
AF Richards, Alastair J.
   Hagelstein, Sue M.
   Patel, Girish K.
   Ivins, Nicola M.
   Sweetland, Helen M.
   Harding, Keith G.
TI Early use of negative pressure therapy in combination with silver
   dressings in a difficult breast abscess
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Breast abscess; Silver dressings; Topical antiseptic; Topical negative
   pressure therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; EFFICACY
AB Combining silver-based dressings with negative pressure therapy after radical excision of chronically infected breast disease is a novel application of two technologies. One patient with complex, chronic, infected breast disease underwent radical excision of the affected area and was treated early with a combination of silver-based dressings and topical negative pressure therapy. The wound was then assessed sequentially using clinical measurements of wound area and depth, pain severity scores and level of exudation. It is possible to combine accepted techniques with modern dressing technologies that result in a positive outcome. In this case, the combination of a silver-based dressing with negative pressure therapy following radical excision proved safe and was well tolerated by the patient. Full epithelisation of the wound was achieved and there was no recurrence of the infection for the duration of the treatment.
C1 [Richards, Alastair J.; Hagelstein, Sue M.; Patel, Girish K.; Ivins, Nicola M.; Sweetland, Helen M.; Harding, Keith G.] Cardiff Univ, Sch Med, Dept Dermatol & Wound Healing, Cardiff CF14 4XN, S Glam, Wales.
C3 Cardiff University
RP Richards, AJ (通讯作者)，Cardiff Univ, Sch Med, Dept Dermatol & Wound Healing, Heath Pk, Cardiff CF14 4XN, S Glam, Wales.
EM richardsaj1@cardiff.ac.uk
RI Patel, Girish/N-7075-2013; Harding, Keith/J-5605-2013
OI Harding, Keith/0000-0003-0048-3279
CR [Anonymous], J WOUND TECHNOL
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bjarnsholt T, 2007, APMIS, V115, P921, DOI 10.1111/j.1600-0463.2007.apm_646.x
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NR 22
TC 13
Z9 15
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2011
VL 8
IS 6
BP 608
EP 611
DI 10.1111/j.1742-481X.2011.00838.x
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 854AL
UT WOS:000297466800007
PM 21883932
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Verbelen, J
   Hoeksema, H
   Heyneman, A
   Pirayesh, A
   Monstrey, S
AF Verbelen, Jozef
   Hoeksema, Henk
   Heyneman, Alexander
   Pirayesh, Ali
   Monstrey, Stan
TI Treatment of Fournier's Gangrene With a Novel Negative Pressure Wound
   Therapy System
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE; MANAGEMENT
AB Fournier's gangrene (FG) is a complex condition that requires surgical debridement, hemodynamic support, antibiotics, and appropriate wound management. This study is the first to assess the use of a low-vacuum negative pressure wound therapy (LV-NPWT) system with low-adherent contact surface in two cases of FG. Methods. The protocol-of-care included twice weekly dressing changes and irrigation with a povidone-iodine-water mixture. Assessments included wound progression (% granulation tissue), ratings of dressing ingrowth, pain during treatment and at dressing changes, patient comfort, and ease-of-use. Results. A 51-year-old man (Patient A) developed FG after surgical removal of a perianal abscess. He received 16 days of LV-NPWT with five dressing changes. A 64-year-old man (Patient B) with multiple comorbidities, developed FG after traumatic injury. He received 20 days of LV-NPWT with six dressing changes. In both patients, LV-NPWT promoted rapid granulation tissue formation. Pain scores averaged low-to-moderate during treatment and dressing changes, and tissue ingrowth was minimal. Conclusion. Overall, ratings were favorable for LV-NPWT ease-of-use and patient comfort. Despite the complexity of these wounds, with the use of LV-NPWT, both wounds progressed to a point where they were able to successfully receive surgical closure with skin grafts and/or flaps. These cases may suggest that LV-NPWT may have a potential role in complex wound management.
C1 [Verbelen, Jozef; Hoeksema, Henk; Heyneman, Alexander; Pirayesh, Ali; Monstrey, Stan] Ghent Univ Hosp, Dept Plast Surg, Wound Healing & Tissue Engn Unit, B-9000 Ghent, Belgium.
C3 Ghent University; Ghent University Hospital
RP Monstrey, S (通讯作者)，Ghent Univ Hosp, Dept Plast Surg, Wound Healing & Tissue Engn Unit, De Pintelaan 185, B-9000 Ghent, Belgium.
EM Stan.monstrey@ugent.be
OI Hoeksema, Henik/0000-0003-3160-4539
FU ConvaTec, Inc.
FX The Department of Plastic and Reconstructive Surgery Wound Healing and
   Tissue Engineering Unit, Gent University Hospital, Gent, Belgium,
   received an unrestricted research grant from ConvaTec, Inc. ConvaTec was
   not involved in the collection or analysis of data. ConvaTec provided
   products for the study.
CR [Anonymous], FOURNIER GANGRENE
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   Moues-Vink CM, TOPICAL NEGATIVE PRE
   Ozturk E, 2009, AM J SURG, V197, P660, DOI 10.1016/j.amjsurg.2008.04.018
   Tahmaz L, 2006, INT J UROL, V13, P960, DOI 10.1111/j.1442-2042.2006.01448.x
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NR 17
TC 8
Z9 9
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2011
VL 23
IS 11
BP 342
EP 349
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 855BL
UT WOS:000297538400005
PM 25881197
DA 2026-07-24
ER
PT J
AU Tipton, AM
   Cohen, SA
   Chelmow, D
AF Tipton, Amanda M.
   Cohen, Stephen A.
   Chelmow, David
TI Wound Infection in the Obese Pregnant Woman
SO SEMINARS IN PERINATOLOGY
LA English
DT Review
DE obesity; cesarean delivery; wound infection; wound seroma; wound
   hematoma; cellulitis
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTION; RISK-FACTORS; CESAREAN
   DELIVERY; DISRUPTION; RECLOSURE; INCISIONS; REDUCE
AB Obesity has been linked as a risk factor for wound complications and is becoming a more common occurrence. We reviewed the risk factors, preventive strategies, and recommended management of wound complications in obese women undergoing cesarean delivery. The limited available data support the use of prophylactic antibiotic before cesarean delivery, closure of subcutaneous space >2 cm, and maintaining normothermia intraoperatively to help reduce the incidence of postoperative wound complications. Data regarding management of cesarean wound complications in the obese patient are sparse, but they do suggest either primary or secondary closure of wounds is preferred to healing by secondary intention. Antibiotics should be administered in the presence of cellulitis or systemic toxicity. Use of vacuum-assisted wound closure devices may be useful in wound management. There is a need for randomized controlled trials which evaluate the prevention and management of wound complications in obese women undergoing cesarean delivery. Semin Perinatol 35:345-349 (C) 2011 Elsevier Inc. All rights reserved.
C1 [Tipton, Amanda M.; Cohen, Stephen A.; Chelmow, David] Virginia Commonwealth Univ, Med Ctr, Dept Obstet & Gynecol, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Chelmow, D (通讯作者)，Virginia Commonwealth Univ, Med Ctr, Dept Obstet & Gynecol, POB 9800034, Richmond, VA 23298 USA.
EM dchelmow@mcvh-vcu.edu
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NR 31
TC 27
Z9 29
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0146-0005
EI 1558-075X
J9 SEMIN PERINATOL
JI Semin. Perinatol.
PD DEC
PY 2011
VL 35
IS 6
BP 345
EP 349
DI 10.1053/j.semperi.2011.05.020
PG 5
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA 858VQ
UT WOS:000297831700007
PM 22108085
DA 2026-07-24
ER
PT J
AU Halvorson, J
   Jinnah, R
   Kulp, B
   Frino, J
AF Halvorson, Jason
   Jinnah, Riyaz
   Kulp, Brenda
   Frino, John
TI Use of Vacuum-assisted Closure in Pediatric Open Fractures With a Focus
   on the Rate of Infection
SO ORTHOPEDICS
LA English
DT Article
ID PRESSURE WOUND THERAPY; OPEN TIBIAL FRACTURES; CHILDREN; EXPERIENCE;
   MANAGEMENT; POPULATION; INJURIES
AB The use of the vacuum-assisted closure device (VAC; KCI, San Antonio, Texas) has given the orthopedist a new tool for the successful management of severe traumatic wounds and open fractures. While the VAC's role in the adult population is proving itself as an improved therapy compared to "traditional wound care," it's role within pediatric orthopedics remains less well defined. Questions remain whether VAC therapy provides benefit regarding decreased infection rates as well as decreased need for extensive soft tissue coverage procedures. A review was therefore performed of a pediatric level I trauma center's experience using the VAC therapy for pediatric open fractures with a focus on the rate of superficial, deep, and chronic infection. A retrospective chart review spanning 4.5 years of all pediatric patients younger than 18 years with an open fracture initially treated with VAC therapy was conducted at a level I pediatric trauma center. This yielded 28 patients with 37 open fractures aged 2 to 17 years who were initially treated with wound VAC therapy. Subsequent chart review of these patients was performed examining in-hospital records, operative notes, and clinical follow-up visits for documented cases of superficial, deep, or chronic infection. Of 37 open pediatric fractures treated with a wound VAC, there were no cases of superficial infection and 2 cases of deep infection for an overall infection rate of 5%. Both infections resolved with surgical intervention and antibiotics without chronic infection development. When compared with historical controls, the use of VAC therapy for pediatric open fractures appears to be an equally safe and effective modality to help reduce infection in pediatric open fractures and should be considered a valuable tool in treating these injuries.
C1 [Halvorson, Jason; Jinnah, Riyaz; Kulp, Brenda; Frino, John] Wake Forest Baptist Hlth, Dept Orthoped Surg, Winston Salem, NC 27103 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Halvorson, J (通讯作者)，Wake Forest Baptist Hlth, Dept Orthoped Surg, Med Ctr Blvd, Winston Salem, NC 27103 USA.
EM jhalvors@wfubmc.edu
FU KCI, San Antonio, Texas
FX In support of the research and preparation of this article, the
   Department of Orthopedic Surgery at Wake Forest Baptist Health received
   grants or outside funding from KCI, San Antonio, Texas.
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NR 22
TC 17
Z9 23
U1 0
U2 10
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
J9 ORTHOPEDICS
JI Orthopedics
PD JUL
PY 2011
VL 34
IS 7
BP E256
EP E260
DI 10.3928/01477447-20110526-15
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 861TA
UT WOS:000298040900004
PM 21717985
DA 2026-07-24
ER
PT J
AU Ooi, A
   Chong, SJ
AF Ooi, A.
   Chong, S. J.
TI Use of adjunctive treatments in improving patient outcome in Fournier's
   gangrene
SO SINGAPORE MEDICAL JOURNAL
LA English
DT Article
DE Fournier's gangrene; hyperbaric oxygen therapy; negative-pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; HYPERBARIC-OXYGEN; FECAL DIVERSION; NECROTIZING
   FASCIITIS; PERINEAL BURNS; MANAGEMENT; EXPERIENCE; MORTALITY; COLOSTOMY;
   SURVIVAL
AB Fournier's gangrene is a polymicrobial necrotising soft tissue infection (NSTI) affecting the perineum and scrotum. It is rapidly progressive and destructive, and is associated with high morbidity and mortality. Management protocol includes prompt diagnosis, early institution of antibiotic therapy and adequate wound debridement, usually requiring multiple operations. The resultant defect can be left to heal by secondary intention, or surgical coverage can be undertaken. We report Fournier's gangrene in a 60-year-old diabetic man and his successful treatment with skin grafting, which utilised a multidisciplinary approach and adjuncts, including negative-pressure wound therapy and hyperbaric oxygen therapy. We also review the literature related to these adjuncts and discuss their usefulness in the management of NSTIs.
C1 [Ooi, A.; Chong, S. J.] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 169608, Singapore.
C3 Singapore General Hospital
RP Ooi, A (通讯作者)，Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
EM dradrianooi@gmail.com
RI Ooi, Adrian/AAJ-8480-2021
OI Ooi, Adrian/0000-0001-7983-3635
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bada-Yllán O, 2006, REV INVEST CLIN, V58, P555
   Bordes J, 2008, BURNS, V34, P840, DOI 10.1016/j.burns.2007.11.009
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NR 18
TC 5
Z9 5
U1 0
U2 3
PU SINGAPORE MEDICAL ASSOC
PI SINGAPORE
PA 2985 JALAN BUKIT MERAH, #02-2C, SMF BUILDING, SINGAPORE, SINGAPORE
SN 0037-5675
J9 SINGAP MED J
JI Singap. Med. J.
PD OCT
PY 2011
VL 52
IS 10
BP E194
EP E197
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 861ZS
UT WOS:000298060200012
PM 22009405
DA 2026-07-24
ER
PT J
AU de Laat, EHEW
   van den Boogaard, MHWA
   Spauwen, PHM
   van Kuppevelt, DHJM
   van Goor, H
   Schoonhoven, L
AF de laat, Erik H. E. W.
   van den Boogaard, Mark H. W. A.
   Spauwen, Paul H. M.
   van Kuppevelt, Dirk H. J. M.
   van Goor, Harry
   Schoonhoven, Lisette
TI Faster Wound Healing With Topical Negative Pressure Therapy in
   Difficult-to-Heal Wounds A Prospective Randomized Controlled
   Trial
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE topical negative pressure; vacuum-assisted closure; sodium hypochlorite;
   difficult-to-heal wounds; pressure ulcer
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; MANAGEMENT; SYSTEM; SORES
AB Objective: A randomized clinical trial was conducted to determine the effectiveness and safety of topical negative pressure therapy in patients with difficult-to-heal wounds.
   Methods: A total of 24 patients were randomly assigned to either treatment with topical negative pressure therapy or treatment with conventional dressing therapy with sodium hypochlorite. The study end point was 50% reduction in wound volume. The maximum follow-up time was 6 weeks.
   Results: The median treatment time to 50% reduction of wound volume in the topical negative pressure group was 2.0 weeks (interquartile range = 1) versus 3.5 weeks (interquartile range = 1.5) in the sodium hypochlorite group (P < 0.001). The unadjusted hazard rate ratio for the time until 50% wound volume reduction was 0.123 (P < 0.001). After adjustment for relevant baseline characteristics in a Cox proportional hazards model treatment group, membership was found as the only and statistically significant indicator for the time to 50% wound volume reduction (hazard rate ratio of 0.117 [P < 0.001]). Subgroup analysis of spinal cord injured patients with severe pressure ulcers showed similar statistically significant results as in the total wound group.
   Conclusion: Topical negative pressure resulted in almost 2 times faster wound healing than treatment with sodium hypochlorite, and is safe to use in patients with difficult-to-heal wounds.
C1 [de laat, Erik H. E. W.; Spauwen, Paul H. M.; van Goor, Harry] Radboud Univ Nijmegen, Med Ctr, Dept Plast Surg, NL-6500 HB Nijmegen, Netherlands.
   [van den Boogaard, Mark H. W. A.] Radboud Univ Nijmegen, Med Ctr, Res Dept Intens & Crit Care, NL-6500 HB Nijmegen, Netherlands.
   [van Kuppevelt, Dirk H. J. M.] Rehabil Ctr, St Maartensklin, Nijmegen, Netherlands.
   [Schoonhoven, Lisette] Radboud Univ Nijmegen, Med Ctr, IQ Sci Inst Qual Healthcare, NL-6500 HB Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Sint Maartens
   Clinic; Radboud University Nijmegen
RP de Laat, EHEW (通讯作者)，Radboud Univ Nijmegen, Med Ctr, Dept Plast Surg 926, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM e.delaat@plchir.umcn.nl
RI van den Boogaard, RN,, Mark/N-5857-2014; Schoonhoven,
   Lisette/O-3330-2013; /P-8241-2015; van Goor, H./H-8035-2014
OI van den Boogaard, RN,, Mark/0000-0003-4233-2903; 
FU department of Nijmegen University Medical Centre
FX the surgical department of Nijmegen University Medical Centre granted
   this study. There is no conflict of interest for this study.
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NR 31
TC 42
Z9 43
U1 1
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2011
VL 67
IS 6
BP 626
EP 631
DI 10.1097/SAP.0b013e31820b3ac1
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 862JB
UT WOS:000298085900025
PM 21629111
DA 2026-07-24
ER
PT J
AU Bassetto, F
   Lancerotto, L
   Salmaso, R
   Pandis, L
   Pajardi, G
   Schiavon, M
   Tiengo, C
   Vindigni, V
AF Bassetto, Franco
   Lancerotto, Luca
   Salmaso, Roberto
   Pandis, Laura
   Pajardi, Giorgio
   Schiavon, Mauro
   Tiengo, Cesare
   Vindigni, Vincenzo
TI Histological evolution of chronic wounds under negative pressure therapy
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Negative pressure therapy; VAC Therapy; Vacuum; Wound; Ulcer
ID VACUUM-ASSISTED CLOSURE; GROWTH; MECHANISMS
AB Background: Negative pressure wound therapy (NPT) has achieved widespread success in the treatment of difficult wounds. However, its effects are but partially explored, and investigations mostly concentrated at the wound-dressing interface; a detailed histological description of the evolution of wounds under NPT is still lacking.
   Materials and Methods: Subsequent punch biopsies of NPT-treated chronic wounds of human patients were analysed. Phenomena occurring in wounds were quantified by analysis of proliferating cells nuclear antigen (PCNA) (proliferating nuclei), CD31 (blood vessels), CD68p (macrophages) and CD45 (lymphocytes) stained slides.
   Results: Three layers were identified in day-0 wounds. Over time, under NPT, the layers behaved differently: the most superficial (1.5 mm) developed granulation tissue, constant in thickness, with high proliferation index, increased in blood vessels density and developed acute inflammation. Instead, the two deeper layers decreased in proliferation rate, maintained vessels density unchanged, were cleared of chronic inflammation and oedema and underwent progression towards stable tissue.
   Discussion: Indeed, while most research has focused on induction of superficial granulation tissue by NPT, deeper layers appear to be also affected, with relieving of chronic inflammation and tissue stabilisation. This may be an important and under-appreciated effect, playing a role in the known positive outcomes of NPT, such as better graft-taking rates. (C) 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Bassetto, Franco; Lancerotto, Luca; Pandis, Laura; Tiengo, Cesare; Vindigni, Vincenzo] Univ Padua, Inst Plast Surg, Padua, Italy.
   [Salmaso, Roberto] Hosp Padova, Dept Pathol, Padua, Italy.
   [Pajardi, Giorgio] Univ Milan, Hand Surg Unit, Dept Plast Surg, Milan, Italy.
   [Schiavon, Mauro] Univ Hosp Udine, Div Plast Surg, Udine, Italy.
C3 University of Padua; University of Padua; Azienda Ospedaliera -
   Universita di Padova; University of Milan; University of Udine;
   University Hospital of Udine
RP Lancerotto, L (通讯作者)，Univ Padua, Inst Plast Surg, Padua, Italy.
EM luca.lancerotto@unipd.it
RI Lancerotto, Luca/A-5745-2013; Vindigni, Vincenzo/K-5059-2016
OI PAJARDI, GIORGIO EUGENIO/0000-0001-6232-034X; TIENGO,
   CESARE/0000-0002-7493-563X; Vindigni, Vincenzo/0000-0001-6638-9010
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   Singer AJ, 1999, NEW ENGL J MED, V341, P738, DOI 10.1056/NEJM199909023411006
   Sisco M, 2009, PLAST RECONSTR SURG, V123, P599, DOI 10.1097/PRS.0b013e318196ba00
   Torbrand C, 2010, J CARDIOTHORAC SURG, V5, DOI 10.1186/1749-8090-5-75
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
   Wilkes R, 2009, J MECH BEHAV BIOMED, V2, P272, DOI 10.1016/j.jmbbm.2008.10.006
NR 28
TC 42
Z9 50
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JAN
PY 2012
VL 65
IS 1
BP 91
EP 99
DI 10.1016/j.bjps.2011.08.016
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 863DW
UT WOS:000298144000021
PM 21885358
DA 2026-07-24
ER
PT J
AU Kollrack, YBM
   Moellenhoff, G
AF Kollrack, Yvonne Bernadette Maria
   Moellenhoff, Gunnar
TI Infected Internal Fixation after Ankle Fractures-A Treatment Path
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE fibula; negative pressure wound therapy; osteosynthesis; surgery; tibia;
   trauma
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY
AB In the emergency treatment of infected internal fixation after ankle fractures, the infection needs to be resolved quickly to protect the implants, bone, and tendons. Vacuum wound therapy (topical negative pressure therapy) has been used for more than 15 years to assist in closure and to accelerate healing of a wide range of wounds. In the present report, we describe the results of treatment of 7 angiopathic (dysvascular) patients who developed a deep wound infection after ankle osteosynthesis. Each patient was treated with initial surgical debridement, followed by vacuum wound therapy and meshed split-thickness skin graft transplantation. The mean inpatient length of vacuum wound therapy was 14.0 +/- 4.31 days, and the mean total duration of vacuum treatment was 54.43 +/- 7.74 days. (C) 2012 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Kollrack, Yvonne Bernadette Maria; Moellenhoff, Gunnar] Univ Munster, Acad Teaching Hosp, Raphaelsklin Muenster, Dept Traumatol, D-48143 Munster, Germany.
C3 University of Munster
RP Kollrack, YBM (通讯作者)，Univ Munster, Acad Teaching Hosp, Raphaelsklin Muenster, Dept Traumatol, Loerstr 23, D-48143 Munster, Germany.
EM e1doktor@yahoo.de
CR Anagnostakos K, 2006, ZBL CHIR, V131, pS87, DOI 10.1055/s-2006-921514
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NR 27
TC 6
Z9 9
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JAN-FEB
PY 2012
VL 51
IS 1
BP 9
EP 12
DI 10.1053/j.jfas.2011.10.018
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 866HU
UT WOS:000298372100003
PM 22196454
DA 2026-07-24
ER
PT J
AU Scala, M
   Spagnolo, F
   Trapasso, M
   Strada, P
   Moresco, L
   Santi, P
AF Scala, Marco
   Spagnolo, Francesco
   Trapasso, Maria
   Strada, Paolo
   Moresco, Luciano
   Santi, Pierluigi
TI Association of Vacuum-assisted Closure and Platelet Gel for the
   Definitive Surgical Repair of an Enterocutaneous Fistula: A Case Report
SO IN VIVO
LA English
DT Article
DE Platelet gel; VAC therapy; regenerative surgery; fistula; wound healing
ID CHRONIC WOUNDS; RICH PLASMA; THERAPY; GRAFTS
AB Background: Regenerative surgery deals with damaged tissue via endogenous cell activation or through autologous cell implantation. Several clinical applications employing cell infusions, platelet gel (PG), or both, are currently applied in cases in which no other therapy is application. The vacuum-assisted closure (VAC) system is a non invasive device used in the management of complicated wounds, which creates sub-atmospheric pressure promoting the wound healing process. Patients and Methods: We describe the case of a 75-year-old woman who underwent several surgical interventions and presented a non-healing ileo-cutaneous fistula. All standard procedures in order to treat the trauma failed, so a treatment associating VAC and PG was performed. Discussion and Conclusion: VAC and PG represent promising opportunities for the treatment of difficult wounds. In this case, the association of regenerative medicine using homologous PG to the VAC therapy was employed in order to enhance the effect of both techniques on tissue repair.
C1 [Scala, Marco] Natl Inst Canc Res IST, Div Surg Oncol, Genoa, Italy.
   [Spagnolo, Francesco; Trapasso, Maria] Natl Inst Canc Res IST, Div Plast Surg, Genoa, Italy.
   [Strada, Paolo] St Martino Hosp, Blood Trasfus Ctr, Genoa, Italy.
   [Moresco, Luciano; Santi, Pierluigi] Univ Genoa, Fac Med, Genoa, Italy.
C3 University of Genoa; IRCCS AOU San Martino IST; University of Genoa;
   IRCCS AOU San Martino IST; University of Genoa
RP Scala, M (通讯作者)，Ist Nazl Ric Canc, SC Oncol Chirurg A, Lgo R Benzi 10, I-16132 Genoa, Italy.
EM marco.scala@hotmail.it
RI Spagnolo, Francesco/AAC-3006-2019
OI Spagnolo, Francesco/0000-0003-3287-1225
CR Akingboye Akinfemi Ayobami, 2010, J Extra Corpor Technol, V42, P20
   Anitua E, 1999, INT J ORAL MAX IMPL, V14, P529
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NR 18
TC 6
Z9 6
U1 0
U2 4
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD JAN-FEB
PY 2012
VL 26
IS 1
BP 147
EP 150
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 868HX
UT WOS:000298515400021
PM 22210730
DA 2026-07-24
ER
PT J
AU Stannard, JP
   Volgas, DA
   McGwin, G
   Stewart, RL
   Obremskey, W
   Moore, T
   Anglen, JO
AF Stannard, James P.
   Volgas, David A.
   McGwin, Gerald, III
   Stewart, Rena L.
   Obremskey, William
   Moore, Thomas
   Anglen, Jeffrey O.
TI Incisional Negative Pressure Wound Therapy After High-Risk Lower
   Extremity Fractures
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article; Proceedings Paper
CT 23rd Annual Meeting of the Orthopaedic-Trauma-Association
CY OCT 17-20, 2007
CL Boston, MA
SP Orthopaed Trauma Assoc
DE negative pressure wound therapy; lower extremity trauma; wound
   dehiscence and infection; tibial plateau fractures; pilon fractures;
   calcaneus fractures
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; PERISTERNAL THORACIC
   WALL; TIBIAL PILON FRACTURES; INTERNAL-FIXATION; BLOOD-FLOW; TEMPORARY
   TREATMENT; OPEN REDUCTION; MANAGEMENT; COMPLICATIONS
AB Objectives: To investigate negative pressure wound therapy (NPWT) to prevent wound dehiscence and infection after high-risk lower extremity trauma.
   Design: Prospective randomized multicenter clinical trial.
   Setting: Four Level I trauma centers.
   Patients/Participants: Blunt trauma patients with one of three high-risk fracture types (tibial plateau, pilon, calcaneus) requiring surgical stabilization.
   Intervention: Incisional NPWT (Group B) was applied to the closed surgical incisions of patients randomized to the study arm of this trial, whereas standard postoperative dressings (Group A) were applied to the control patients.
   Main Outcome Measures: Acute and chronic wound dehiscence and infection.
   Results: Two hundred forty-nine patients with 263 fractures have enrolled in this study with 122 randomized to Group A (controls) and 141 to Group B (NPWT). There was no difference between the groups in the distribution of calcaneus (39%), pilon (17%), or tibial plateau (44%) fractures. There were a total of 23 infections in Group A and 14 in Group B, which represented a significant difference in favor of NPWT (P = 0.049). The relative risk of developing an infection was 1.9 times higher in control patients than in patients treated with NPWT (95% confidence interval, 1.03-3.55).
   Conclusions: There have been no studies evaluating incisional NPWT as a prophylactic treatment to prevent infection and wound dehiscence of high-risk surgical incisions. Our data demonstrate that there is a decreased incidence of wound dehiscence and total infections after high-risk fractures when patients have NPWT applied to their surgical incisions after closure. There is also a strong trend for decreases in acute infections after NPWT. Based on our data in this multicenter prospective randomized clinical trial, NPWT should be considered for high-risk wounds after severe skeletal trauma.
C1 [Stannard, James P.] Univ Missouri, Dept Orthopaed, Columbia, MO 65212 USA.
   [McGwin, Gerald, III] Univ Alabama Birmingham, Callahan Eye Fdn Hosp 609, Birmingham, AL USA.
   [Obremskey, William] Vanderbilt Orthopaed Inst, Nashville, TN USA.
   [Moore, Thomas] Emory Univ, Sch Med, Atlanta, GA USA.
   [Anglen, Jeffrey O.] Indiana Univ, Med Ctr, Indianapolis, IN USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Alabama System; University of Alabama Birmingham;
   Vanderbilt University; Emory University; Indiana University System;
   Indiana University Indianapolis
RP Stannard, JP (通讯作者)，Univ Missouri, Dept Orthopaed, 1 Hosp Dr,MC213,DC053-00, Columbia, MO 65212 USA.
EM StannardJ@health.missouri.edu
RI ; Obremskey, William/HRA-4704-2023
OI Anglen, Jeffrey/0000-0001-9910-6611; Stannard, James
   P/0000-0001-8467-6494; Obremskey, William/0000-0002-8942-1842
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NR 41
TC 291
Z9 338
U1 2
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD JAN
PY 2012
VL 26
IS 1
BP 37
EP 42
DI 10.1097/BOT.0b013e318216b1e5
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics; Sport Sciences
GA 868UO
UT WOS:000298551600009
PM 21804414
DA 2026-07-24
ER
PT J
AU Hou, ZY
   Irgit, K
   Strohecker, KA
   Matzko, ME
   Wingert, NC
   DeSantis, JG
   Smith, WR
AF Hou, Zhiyong
   Irgit, Kaan
   Strohecker, Kent A.
   Matzko, Michelle E.
   Wingert, Nathaniel C.
   DeSantis, Joseph G.
   Smith, Wade R.
TI Delayed Flap Reconstruction With Vacuum-Assisted Closure Management of
   the Open IIIB Tibial Fracture
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE VAC; Open fractures; Wounds; IIIB; Delayed closure; Complication
ID PRESSURE WOUND THERAPY; SOFT-TISSUE INJURIES; LOWER-EXTREMITY; COVERAGE;
   DEFECTS
AB Objective: Vacuum-assisted closure (VAC) therapy has been shown to be effective at reducing bacterial counts in wounds until definitive bony coverage. However, there is continued debate over timing and type of definitive wound coverage even with VAC therapy application.
   Methods: From 2004 to 2009, 32 patients with Gustilo type IIIB open tibia fractures were initially treated with VAC therapy were included. The number of debridements, length of treatment with VAC dressing, definitive wound coverage management, and length of hospital stay, flap-related complications, and time to radiographic fracture healing were recorded.
   Results: The mean Injury Severity Score was 17.3 +/- 2.0. All wounds closed after being treated with the primary VAC closure. The mean interval between the initial injury and definitive intervention was 10.9 days +/- 0.3 days. Twenty of 27 patients (74%) underwent rotational muscle flaps; four received free muscle flaps and three only with split-thickness skin grafts for definitive wound coverage. Nine of 32 patients (28%) underwent below knee amputation, five without flap coverage after several VAC sessions and four after definitive flap coverage. The average time to union was 10.0 months +/- 2.0 months. Eight patients developed nonunion and 11 patients developed infections. The average follow-up time is 2.4 years +/- 0.2 years. Patients were divided into two groups for analysis according to the interval time. The rate of infection was significantly increased in patients who had an interval of more than 7 days from the time of injury to flap coverage.
   Conclusions: The VAC therapy may help to reduce the flap size and need for a flap transfer for type IIIB open tibial fractures. However, prolonged periods of VAC usage, greater than 7 days, should be avoided to reduce higher infection and amputation risks.
C1 [Hou, Zhiyong] Hebei Med Univ, Hosp 3, Dept Orthopaed Surg, Shijiazhuang 050051, Hebei, Peoples R China.
   [Smith, Wade R.] Mt Orthopaed Trauma Surg Swedish, Englewood, CO USA.
   [Irgit, Kaan; Strohecker, Kent A.; Matzko, Michelle E.; Wingert, Nathaniel C.; DeSantis, Joseph G.] Geisinger Med Ctr, Dept Orthopaed Surg, Danville, PA 17822 USA.
C3 Hebei Medical University; Geisinger Medical Center
RP Hou, ZY (通讯作者)，Hebei Med Univ, Hosp 3, Dept Orthopaed Surg, Shijiazhuang 050051, Hebei, Peoples R China.
EM hzy707@yahoo.com.cn
OI MATZKO, MICHELLE/0000-0003-3544-0826; Hou, Zhiyong/0000-0001-5838-4025
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NR 25
TC 83
Z9 101
U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD DEC
PY 2011
VL 71
IS 6
BP 1705
EP 1708
DI 10.1097/TA.0b013e31822e2823
PG 4
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 869RT
UT WOS:000298616400047
PM 22182878
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Malmsjö, M
   Hansson, J
   Hlebowicz, J
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Hansson, Johan
   Hlebowicz, Joanna
   Ingemansson, Richard
TI Microvascular Blood Flow Changes in the Small Intestinal Wall During
   Conventional Negative Pressure Wound Therapy and Negative Pressure Wound
   Therapy Using a Protective Disc Over the Intestines in Laparostomy
SO ANNALS OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL
   HYPERTENSION; MANAGEMENT; FISTULAS
AB Objectives: Blood flow changes in the intestines during conventional negative pressure wound therapy (NPWT), and NPWT using a protective disc over the intestines in laparostomy.
   Background: Higher closure rates of the open abdomen have been reported with NPWT compared with other kinds of wound management. However, the method has been associated with increased development of fistulae. We have compared the changes in blood flow in the intestinal wall using conventional NPWT and NWPT with a protective disc between the intestines and the vacuum source.
   Methods: Midline incisions were made in 10 pigs and either conventional NPWT or NPWT with a disc over the intestines was applied. The microvascular blood flow was measured in the intestinal wall before and after the application of topical negative pressures of -50, -70, and -120 mmHg, using laser Doppler velocimetry.
   Results: The blood flow was significantly decreased (by 24%) after the application of conventional NPWT at -50 mmHg, compared with a slight decrease (2%) after the application of NWPT with a protective disc (P < 0.05). The blood flow was significantly decreased (by 54%) after the application of conventional NPWT at -120 mmHg, compared with a slight decrease (17%) after application of NPWT using a protective disc (P < 0.001).
   Conclusions: Inserting a disc between the intestines and the vacuum source in NPWT protects the intestines from ischemia. The decreased blood flow in the intestinal wall may induce ischemia, which could promote the development of intestinal fistulae.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Lindstedt, Sandra; Malmsjo, Malin; Hlebowicz, Joanna; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Hansson, Johan] Uppsala Univ, Fac Med, Inst Surg Sci, Uppsala, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Uppsala University; Lund University
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Maljö, Malin/0000-0001-9849-9599;
   Ingemansson, Richard/0000-0001-7623-8953
CR Becker HP, 2007, SCAND J SURG, V96, P263, DOI 10.1177/145749690709600402
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NR 28
TC 16
Z9 18
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JAN
PY 2012
VL 255
IS 1
BP 171
EP 175
DI 10.1097/SLA.0b013e31823c9ffa
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 869ZM
UT WOS:000298638900026
PM 22104565
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Gustafsson, L
   Lindstedt, S
   Ingemansson, R
AF Malmsjo, Malin
   Gustafsson, Lotta
   Lindstedt, Sandra
   Ingemansson, Richard
TI Negative Pressure Wound Therapy-associated Tissue Trauma and Pain: A
   Controlled In vivo Study Comparing Foam and Gauze Dressing
   Removal by Immunohistochemistry for Substance P and Calcitonin
   Gene-related Peptide in the Wound Edge
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE animal model; controlled study; negative pressure wound therapy; pain;
   dressing
ID CLOSURE; LIDOCAINE; IMPACT
AB Pain upon negative pressure wound therapy (NPWT) dressing removal has been reported and is believed to be associated with the observation that granulation tissue grows into foam. Wound tissue damage upon removal of the foam may cause the reported pain. Calcitonin gene-related peptide (CGRP) and substance P are neuropeptides that cause inflammation and signal pain and are known to be released when tissue trauma occurs. The aim of this controlled in vivo study was to compare the expression of CGRP and substance P in the wound bed in control wounds and following NPWT and foam or gauze dressing removal. Eight pigs with two wounds each were treated with open-pore structure polyurethane foam or AMD gauze and NPWT of 0 (control) or -80 mm Hg for 72 hours. Following removal of the wound filler, the expression of CGRP and substance P was measured, using arbitrary units, in sections of biopsies from the wound bed using immunofluorescence techniques. Substance P and CGRP were more abundant in the wound edge following the removal of foam than of gauze dressings and least abundant in control wounds. The immunofluorescence staining of the wound edge for CGRP was 52 +/- 3 au after the removal of gauze and 97 +/- 5 au after the removal of foam (P < 0.001). For substance P, the staining was 55 +/- 3 au after gauze removal and 95 +/- 4 au after foam removal (P < 0.001). CGRP and substance P staining was primarily located to nerves and leukocytes. The increase in CGRP and substance P immunofluorescence was especially prominent in the dermis but also was seen in subcutaneous and muscle tissue. Using gauze may be one way of reducing NPWT dressing change-related pain. New wound fillers designed to optimize granulation tissue formation and minimize pain issues presumably will be developed in the near future.
C1 [Malmsjo, Malin; Gustafsson, Lotta] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Malmsjo, Malin; Lindstedt, Sandra; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473;
   Gustafsson, Lotta/0000-0002-9826-9133
FU Swedish Medical Research Council; Lund University Faculty of Medicine;
   Swedish Government; Lund University Hospital; Swedish Medical
   Association; Royal Physiographic Society in Lund; Ake Wiberg Foundation;
   Anders Otto Sward Foundation/Ulrika Eklund Foundation; Magn Bergvall
   Foundation; Crafoord Foundation; Anna-Lisa and Sven-Erik Nilsson
   Foundation; Jeanssom Foundation; Swedish Heart-Lung Foundation; Anna and
   Edvin Berger's Foundation; Marta Lundqvist Foundation; Lars Hierta's
   Memorial Foundation; Prospera (Forth Worth, TX)
FX This study was supported by the Swedish Medical Research Council, Lund
   University Faculty of Medicine, the Swedish Government Grant for
   Clinical Research, Lund University Hospital Research Grants, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the Ake
   Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika Eklund
   Foundation, the Magn Bergvall Foundation, the Crafoord Foundation, the
   Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeanssom Foundation, the
   Swedish Heart-Lung Foundation, Anna and Edvin Berger's Foundation, the
   Marta Lundqvist Foundation, Lars Hierta's Memorial Foundation, and
   Prospera (Forth Worth, TX).
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NR 21
TC 12
Z9 17
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD DEC
PY 2011
VL 57
IS 12
BP 30
EP 35
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 871XR
UT WOS:000298771500007
PM 22156176
DA 2026-07-24
ER
PT J
AU Kumar, AR
   Hunt, P
   Ritter, EM
   Howard, R
AF Kumar, Anand R.
   Hunt, Pasha
   Ritter, E. Matthewe
   Howard, Robert
TI Successful Knee Extensor Mechanism Reconstruction in a Warfare-Related
   Open Lower Extremity Injury Complicated by Mucormycosis Infection: A
   Case Report
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE subcutaneous zygomycosis; limb salvage; knee extensor mechanism
   reconstruction; warfare-related lower extremity trauma
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; MANAGEMENT; EXPERIENCE;
   THERAPY; DEVICE
AB Subcutaneous zygomycosis infection associated with a lower extremity open fracture is a potentially life- and limb-threatening condition. This rare and poorly characterized infection complicating war wounds is unique, complex, and poses a significant reconstructive challenge. The objective of this article is to report the reconstruction of a complex Gustilo IIIC warfare-related distal femur fracture with partial extensor mechanism loss complicated by a subcutaneous zygomycosis infection using a novel combination of local and systemic antifungals with negative pressure wound therapy. Negative pressure wound therapy with silver-impregnated sponges and antibiotic/antifungal beads was used to provide temporary wound coverage, improve revascularization, and deliver local antifungal therapy. The distal open femur fracture was fixed using a lateral approach and the medial distal thigh wound and extensor mechanism were reconstructed using an extended gastrocnemius flap with skin graft. The limb was successfully salvaged and the patient is now ambulatory.
C1 [Kumar, Anand R.; Howard, Robert] Natl Naval Med Ctr, Dept Plast & Reconstruct Surg, Bethesda, MD USA.
   [Kumar, Anand R.; Hunt, Pasha; Ritter, E. Matthewe; Howard, Robert] Uniformed Serv Univ Hlth Sci, Dept Surg Plast Surg, Bethesda, MD 20814 USA.
   [Ritter, E. Matthewe] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA.
C3 Walter Reed National Military Medical Center; Uniformed Services
   University of the Health Sciences - USA; Walter Reed National Military
   Medical Center
RP Kumar, AR (通讯作者)，Natl Naval Med Ctr, Dept Plast & Reconstruct Surg, Bethesda, MD USA.
EM arkumar@mac.com
OI Kumar, Anand/0000-0002-4429-0236
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NR 18
TC 5
Z9 5
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD FEB
PY 2012
VL 26
IS 2
BP E7
EP E10
DI 10.1097/BOT.0b013e318214e2c6
PG 4
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 877RQ
UT WOS:000299200000001
PM 22048185
DA 2026-07-24
ER
PT J
AU Schintler, MV
AF Schintler, M. V.
TI Negative pressure therapy: theory and practice
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article; Proceedings Paper
CT 6th International Symposium on the Diabetic Foot
CY MAY 10-14, 2011
CL Noordwijkerhout, NETHERLANDS
DE negative pressure therapy; efficacy; practice
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; WOUND THERAPY; STATE
AB Negative pressure (wound) therapy, synonymous with topical negative pressure or vacuum therapy mainly cited as branded VAC (R) (vacuum-assisted closure) therapy, is a mode of therapy used to encourage wound healing. It is used both as primary treatment of chronic and complex wounds and as an adjunct for temporary closure and wound bed preparation preceding surgical procedures such as skin grafts and flap surgery. The device has come into wide and successful use, although the physiological basis of its effect is not yet fully understood, and with a delay, increasingly evidence-based data become available. A meta-analysis was made of peer-reviewed publications (PubMedMedline) chosen on the basis of inclusion of the terms randomized clinical trial, vacuum-assisted closure, and topical negative pressure. Scientific data were evaluated from experimental animal studies, randomized clinical trials, observations of clinical applications, and case reports on all known effects of VAC therapy. Systematic analysis of the data shows efficacy concerning induction of wound healing mechanisms, especially in the early stage. Increased perfusion can be considered proven. Data analysis shows positive efficacy for treatment of infection. Although this therapy appears effective and its superiority to conventional techniques has been demonstrated, there are still some critical votes concerning efficacy. Because its mechanisms of action remain unclear, and because there is still some gap between evidence-based data and the excellent clinical results, further prospective, randomized, blinded studies are needed. Even so, we conclude that vacuum therapy, used when indicated and especially by experienced surgeons, is an excellent tool to support wound healing. Copyright (C) 2012 John Wiley & Sons, Ltd.
C1 [Schintler, M. V.] Med Univ Graz, Div Plast & Reconstruct Surg, A-8036 Graz, Austria.
C3 Medical University of Graz
RP Schintler, MV (通讯作者)，Med Univ Graz, Klin Abt Plast Asthet & Rekonstrukt Chirurg, Auenbruggerpl 29, A-8036 Graz, Austria.
EM michael.schintler@medunigraz.at
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NR 43
TC 63
Z9 87
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD FEB
PY 2012
VL 28
SU 1
BP 72
EP 77
DI 10.1002/dmrr.2243
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 880AY
UT WOS:000299377700014
PM 22271727
OA Bronze
DA 2026-07-24
ER
PT J
AU Game, FL
   Hinchliffe, RJ
   Apelqvist, J
   Armstrong, DG
   Bakker, K
   Hartemann, A
   Löndahl, M
   Price, PE
   Jeffcoate, WJ
AF Game, F. L.
   Hinchliffe, R. J.
   Apelqvist, J.
   Armstrong, D. G.
   Bakker, K.
   Hartemann, A.
   Londahl, M.
   Price, P. E.
   Jeffcoate, W. J.
TI A systematic review of interventions to enhance the healing of chronic
   ulcers of the foot in diabetes
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article; Proceedings Paper
CT 6th International Symposium on the Diabetic Foot
CY MAY 10-14, 2011
CL Noordwijkerhout, NETHERLANDS
DE diabetes; diabetic foot; ulcer; wound healing; dressing
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; RANDOMIZED
   CONTROLLED-TRIAL; FIBROBLAST-GROWTH-FACTOR; DOUBLE-BLIND; NEUROPATHIC
   ULCERS; LIMB SALVAGE; MANAGEMENT; PLACEBO; MULTICENTER
AB The outcome of management of diabetic foot ulcers is poor, and there is continuing uncertainty concerning optimal approaches to management. It was for these reasons that in 2006 the International Working Group of the Diabetic Foot (IWGDF) working group on wound healing undertook a systematic review of the evidence to inform protocols for routine care and to highlight areas which should be considered for further study. The same working group has now updated this review by considering papers on the interventions to improve the healing of chronic ulcers published between December 2006 and June 2010. Methodological quality of selected studies was independently assessed by two reviewers using Scottish Intercollegiate Guidelines Network criteria. Selected studies fell into the following ten categories: sharp debridement and wound bed preparation with larvae and hydrotherapy; wound bed preparation using antiseptics, applications and dressing products; resection of the chronic wound; hyperbaric oxygen therapy (HBOT); compression or negative pressure therapy; products designed to correct aspects of wound biochemistry and cell biology associated with impaired wound healing; application of cells, including platelets and stem cells; bioengineered skin and skin grafts; electrical, electromagnetic, lasers, shockwaves and ultrasound; other systemic therapies which did not fit in the above categories. Heterogeneity of studies prevented pooled analysis of results.
   Of the 1322 papers identified, 43 were selected for grading following full text review. The present report is an update of the earlier IWGDF systematic review, but the conclusion is similar: that with the exception of HBOT and, possibly, negative pressure wound therapy, there is little published evidence to justify the use of newer therapies. This echoes the conclusion of a recent Cochrane review and the systematic review undertaken by the National Institute for Health and Clinical Excellence Guidelines Committee in the UK. Analysis of evidence presents considerable difficulties in this field particularly as controlled studies are few and the majority are of poor methodological quality. Copyright (C) 2012 John Wiley & Sons, Ltd.
C1 [Game, F. L.] Derby Hosp NHS Trust, Dept Endocrinol & Diabet, Derby DE22 3NE, England.
   [Game, F. L.; Jeffcoate, W. J.] Nottingham Univ Hosp Trust, Foot Ulcer Trials Unit, Nottingham, England.
   [Hinchliffe, R. J.] St Georges Healthcare NHS Trust, St Georges Vasc Inst, London, England.
   [Apelqvist, J.] Malmo Univ Hosp, Dept Endocrinol, Malmo, Sweden.
   [Armstrong, D. G.] Univ Arizona, Coll Med, So Arizona Limb Salvage Alliance SALSA, Tucson, AZ USA.
   [Bakker, K.] IWGDF, Heemstede, Netherlands.
   [Hartemann, A.] Hop La Pitie Salpetriere, Assistance Publ Hop Paris, Serv Diabetol, Paris, France.
   [Hartemann, A.] Univ P&M Curie, Paris, France.
   [Londahl, M.] Univ Lund Hosp, Dept Endocrinol, S-22185 Lund, Sweden.
   [Londahl, M.] Inst Clin Sci Lund, Lund, Sweden.
   [Price, P. E.] Cardiff Univ, Sch Healthcare Studies, Cardiff, S Glam, Wales.
C3 University of Nottingham; Nottingham University Hospital NHS Trust; City
   St Georges, University of London; Lund University; Skane University
   Hospital; University of Arizona; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP;
   Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite;
   Sorbonne Universite; Lund University; Skane University Hospital; Cardiff
   University
RP Game, FL (通讯作者)，Derby Hosp NHS Trust, Dept Endocrinol & Diabet, Uttoxeter Rd, Derby DE22 3NE, England.
EM fgame@futu.co.uk
RI ; Price, Patricia/B-5817-2013
OI Game, Frances/0000-0002-5294-4789; Löndahl, Magnus/0000-0003-1522-3920; 
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NR 55
TC 157
Z9 187
U1 0
U2 66
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD FEB
PY 2012
VL 28
SU 1
BP 119
EP 141
DI 10.1002/dmrr.2246
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 880AY
UT WOS:000299377700024
PM 22271737
OA Bronze
DA 2026-07-24
ER
PT J
AU Jones, EG
   El-Zawahry, AM
AF Jones, Elizabeth Geiger
   El-Zawahry, Ahmed M.
TI Curative Treatment Without Surgical ReconstructionaAftr Perineal
   Debridement of Fournier's Gangrene
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
ID HYPERBARIC-OXYGEN; MANAGEMENT; THERAPY
AB BACKGROUND: Fournier's gangrene (necrotizing fasciitis) is an acute life-threatening disease of the perineal area that requires urgent medical intervention. Once the affected area is surgically debrided and the patient is stabilized, surgical management typically involves 1 or more additional procedures that may include split-thickness skin grafts, flaps, or an elective diverting urostomy and/or colostomy. The professional literature discussing nonsurgical approaches to healing for Fournier's gangrene after surgical debridement is sparse.
   CASE: We present 3 cases of male patients with Fournier's gangrene from our facility who healed uneventfully with negative pressure wound therapy placed after extensive debridement without further surgical intervention. An added benefit was a satisfactory aesthetic effect.
   CONCLUSION: Expert wound management including negative pressure wound therapy after surgical debridement of Fournier's gangrene eliminated the need for further operative procedures and prolonged hospitalizations in these cases. We believe that surgical teams should consider using negative pressure wound therapy as part of the initial curative plan of care after debridement, and that plans for restorative plastic surgery should be restricted to patients who do not exhibit adequate improvement with conservative wound management.
C1 [El-Zawahry, Ahmed M.] Med Univ S Carolina, Charleston, SC USA.
   [El-Zawahry, Ahmed M.] Ralph H Johnson VA Med Ctr, Dept Urol, Charleston, SC 29401 USA.
C3 Medical University of South Carolina; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Ralph H Johnson VA Medical Center
EM Gwammyliz@heavi.tv
RI El-Zawahry, Ahmed/ABD-8024-2020
CR Beltran S, 2008, REV CHILENA CIRUGLA, V60, P303
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NR 15
TC 5
Z9 8
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1071-5754
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JAN-FEB
PY 2012
VL 39
IS 1
BP 98
EP 102
DI 10.1097/WON.0b013e31823fe212
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 881OY
UT WOS:000299497200012
PM 22237647
DA 2026-07-24
ER
PT J
AU de Weerd, L
   Kjæve, J
   Gurgia, L
   Weum, S
AF de Weerd, L.
   Kjaeve, J.
   Gurgia, L.
   Weum, S.
TI A large abdominal intercostal hernia in a patient with vascular type
   Ehlers-Danlos syndrome: a surgical challenge
SO HERNIA
LA English
DT Article; Proceedings Paper
CT Conference on Abdominal Wall Reconstruction
CY JUN 25-27, 2009
CL Washington, DC
DE Abdominal wall reconstruction; Abdominal intercostal hernia; Vacuum
   assisted closure system
ID REPAIR
AB A patient with vascular type Ehlers-Danlos syndrome developed a large abdominal intercostal hernia secondary to coughing. The tissue friability and associated risks for arterial ruptures and visceral perforations in these patients make hernia repair challenging. The hernia was successfully treated using a novel approach.
C1 [de Weerd, L.; Gurgia, L.] Univ Hosp N Norway, Dept Plast Surg & Hand Surg, N-9038 Tromso, Norway.
   [Kjaeve, J.] Univ Hosp N Norway, Dept Gastrointestinal Surg, N-9038 Tromso, Norway.
   [Weum, S.] Univ Hosp N Norway, Dept Radiol, N-9038 Tromso, Norway.
C3 UiT The Arctic University of Tromso; University Hospital of North
   Norway; UiT The Arctic University of Tromso; University Hospital of
   North Norway; UiT The Arctic University of Tromso; University Hospital
   of North Norway
RP de Weerd, L (通讯作者)，Univ Hosp N Norway, Dept Plast Surg & Hand Surg, Sykehusveien 38, N-9038 Tromso, Norway.
EM louis.deweerd@unn.no
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   BEIGHTON PH, 1969, GUT, V10, P1004, DOI 10.1136/gut.10.12.1004
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NR 13
TC 17
Z9 21
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
J9 HERNIA
JI Hernia
PD FEB
PY 2012
VL 16
IS 1
BP 117
EP 120
DI 10.1007/s10029-010-0721-9
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 881WL
UT WOS:000299521900018
PM 20848297
OA hybrid
DA 2026-07-24
ER
PT J
AU Ngo, QD
   Vickery, K
   Deva, AK
AF Ngo, Quan D.
   Vickery, Karen
   Deva, Anand K.
TI The effect of topical negative pressure on wound biofilms using an in
   vitro wound model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BACTERIAL BIOFILMS; RESISTANCE; THERAPY;
   SILVER; OXYGEN; ACID
AB Chronic non-healing wounds affect a significant number of patients worldwide. Although the etiologies of these wounds are varied, bacterial infection has been suggested as a major factor responsible for the perpetual inflammation and tissue destruction observed in such wounds. Recent evidence has emerged suggesting that bacterial biofilms in particular may have a significant role in this process. At the same time, topical negative pressure dressing is gaining acceptance as a therapy which promotes healing in recalcitrant wounds. In this study an in vitro Pseudomonas aeruginosa biofilm model was developed to mimic potential surface wound biofilms. Topical negative pressure dressing was applied to the model and the effects of topical negative pressure dressing on the in vitro wound biofilms were examined using both quantitative microbiological counting technique and imaging studies. The results demonstrated a small but statistically significant reduction in biofilm bacteria at 2 weeks when exposed to topical negative pressure. When this was combined with silver impregnated foam, the reduction was far more significant and was observable within 24 hours. Microscopically, it was also noted that topical negative pressure compressed the biofilm architecture with a reduction in thickness and diffusion distance.
C1 [Ngo, Quan D.] Univ Sydney, Dept Maxillofacial & Plast Surg, S Western Sydney Med Sch, Sydney, NSW 2006, Australia.
   [Vickery, Karen; Deva, Anand K.] Macquarie Univ, SIRG, Australian Sch Adv Med, N Ryde, NSW, Australia.
C3 University of Sydney; Macquarie University
RP Ngo, QD (通讯作者)，70 Meadows Rd, Mt Pritchard, NSW 2170, Australia.
EM drain_master@hotmail.com
OI ngo, quan/0000-0003-0415-0762; Deva, Anand/0000-0002-0314-7177; Vickery,
   Karen/0000-0003-0998-1370
FU Department of Infectious Disease, University of Sydney
FX The work presented herein was made possible with very generous help from
   the staff at the Infectious Disease and Virology Departments at the
   University of Sydney, especially Prof. Y. Cossart, Prof. R. Kearney, Ms.
   Kate Gilchrist, and Dr. Jean Zou. Funding was provided by the Department
   of Infectious Disease, University of Sydney.
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   Monzón M, 2001, J ANTIMICROB CHEMOTH, V48, P793, DOI 10.1093/jac/48.6.793
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Parsek MR, 2003, ANNU REV MICROBIOL, V57, P677, DOI 10.1146/annurev.micro.57.030502.090720
   Percival SL, 2005, J HOSP INFECT, V60, P1, DOI 10.1016/j.jhin.2004.11.014
   Stacey MC, 2004, MED J AUSTRALIA, V180, P316, DOI 10.5694/j.1326-5377.2004.tb05962.x
   Sun Y, 2008, WOUND REPAIR REGEN, V16, P805, DOI 10.1111/j.1524-475X.2008.00434.x
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
   Yildiz FH, 2004, MOL MICROBIOL, V53, P497, DOI 10.1111/j.1365-2958.2004.04154.x
NR 42
TC 65
Z9 73
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN-FEB
PY 2012
VL 20
IS 1
BP 83
EP 90
DI 10.1111/j.1524-475X.2011.00747.x
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 882GE
UT WOS:000299551000054
PM 22126340
DA 2026-07-24
ER
PT J
AU Willms, A
   Güsgen, C
   Schreyer, C
   Becker, HP
   Schwab, R
AF Willms, A.
   Guesgen, C.
   Schreyer, C.
   Becker, H-P.
   Schwab, R.
TI Prevention of Small Bowel Fistulas During Open Abdominal Treatment:
   Lessons Learned
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE open abdomen; intraabdominal vacuum therapy; VAC (R)-therapy; small
   bowel fistula; abdominal trauma; laparostomy
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; FASCIAL CLOSURE; WALL DEFECTS;
   TEMPORARY CLOSURE; VENTRAL HERNIA; WOUND CLOSURE; MANAGEMENT; SEPSIS;
   TRAUMA
AB Background: Abdominal vacuum therapy has simplified the treatment of a laparostoma. But is that all that it can achieve? The role of abdominal vacuum therapy concerning the development of small bowel fistulas is still under discussion. Treatment of the bowel surface seems to be crucial for the prevention of fistulas. As military surgeons, we need a simple, standardised regimen, leading to reproducible good results and low complication rates. The question is: are we able to eliminate small bowel fistula during open abdominal treatment?
   Patients and Methods: We analysed 28 consecutive patients with open abdominal treatment in the period of 2004 to 2009. From June 2006 on, we implemented an algorithm, using the KCI V.A.C.(R) Abdominal Dressing (Kinetic Concepts Inc., San Antonio, Texas, USA) and a vicryl mesh between the non-adherent layer and the foam to prevent fascial retraction. The patients treated after the installation of the new algorithm were compared to a group treated from 2004 to May 2006 before its installation. Fistula rates, mortality, the fascial closure rate, the number of abdominal dressing changes and the duration of open abdominal treatment were evaluated.
   Results: After implementation of our new algorithm, the fistula rate decreased from 45% to 0%. The mortality during open abdominal treatment decreased from 45% to 6%. In addition, the duration of open abdominal treatment was reduced as well as the number of dressing changes. The primary fascial closure rate was 87%.
   Conclusion: We implemented a regimen, which is suitable for our mission in Afghanistan, as well as for medical evacuation and for the treatment of patients in our hospitals in Germany. It ensures a standardised treatment of the open abdominal cavity with an ideal protecting treatment of the bowel surface. Our algorithm utilises the advantages of the laparostoma while minimising the complications. The development of a small bowel fistula was eliminated in the evaluated patient group and mortality was clearly reduced.
C1 [Willms, A.; Guesgen, C.; Schreyer, C.; Becker, H-P.; Schwab, R.] Bundeswehrzent Krankenhaus Allgemein Viszeral & T, D-56072 Koblenz, Germany.
RP Willms, A (通讯作者)，Bundeswehrzent Krankenhaus Allgemein Viszeral & T, Rubenacherstr 170, D-56072 Koblenz, Germany.
EM ArnulfWillms@gmx.de
RI Schreyer, Christof/AHC-9023-2022; Willms, Arnulf/AFN-0812-2022
OI Willms, Arnulf/0000-0001-9998-6735
CR An G, 2004, J TRAUMA, V56, P1266, DOI 10.1097/01.TA.0000068241.66186.00
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Barker DE, 2007, J AM COLL SURGEONS, V204, P784, DOI 10.1016/j.jamcollsurg.2006.12.039
   Becker HP, 2007, SCAND J SURG, V96, P263, DOI 10.1177/145749690709600402
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   BROCK WB, 1995, AM SURGEON, V61, P30
   de Costa A, 2006, ANZ J SURG, V76, P356, DOI 10.1111/j.1445-2197.2006.03638.x
   Evenson RA, 2006, CHIRURG, V77, P594, DOI 10.1007/s00104-006-1207-2
   Fischer JE, 2008, AM J SURG, V196, P1, DOI 10.1016/j.amjsurg.2008.01.001
   Gäddnäs F, 2007, SCAND J SURG, V96, P301
   Ivatury R, 2009, WORLD J SURG, V33, P1150, DOI 10.1007/s00268-009-0005-7
   Jamshidi R, 2007, ARCH SURG-CHICAGO, V142, P793, DOI 10.1001/archsurg.142.8.793
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   Stevens P, 2009, INT WOUND J, V6, P259, DOI 10.1111/j.1742-481X.2009.00614.x
   Subramonia S, 2009, WORLD J SURG, V33, P931, DOI 10.1007/s00268-009-9947-z
   Tsuei BJ, 2004, AM SURGEON, V70, P652
   Utzolino S, 2010, ZBL CHIR, V135, P240, DOI 10.1055/s-0030-1247360
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   Wild T, 2004, ZENTRALBL CHIR S1, V129, P7
   Wild T, 2006, ZENTRALBL CHIR S1, V131, P111
   Wondberg D, 2008, WORLD J SURG, V32, P2724, DOI 10.1007/s00268-008-9762-y
NR 37
TC 8
Z9 8
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD DEC
PY 2011
VL 136
IS 6
BP 592
EP 597
DI 10.1055/s-0031-1271440
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 883BS
UT WOS:000299608200015
PM 21563053
DA 2026-07-24
ER
PT J
AU Cattoni, DI
   Ravazzola, C
   Tüngler, V
   Wainstein, DE
   Chara, O
AF Cattoni, Diego I.
   Ravazzola, Constanza
   Tuengler, Victoria
   Wainstein, Daniel E.
   Chara, Osvaldo
TI Effect of intestinal pressure on fistula closure during vacuum assisted
   treatment: A computational approach
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Enterocutaneous fistula; Intestinal pressure; Fistula radius;
   Simulation; Computational model
ID ENTEROCUTANEOUS FISTULAS; MANAGEMENT; MODEL; MANOMETRY; MOTILITY;
   GROWTH; MOTOR
AB Background: Enterocutaneous fistulae, pathological communications between the intestinal lumen and the abdominal skin, can arise as serious complication of gastrointestinal surgery. A current non-surgical treatment for this pathology involves topical application of sub-atmospheric pressure, also known as vacuum assisted closure (VAC). While this technique appears to be promising, surgeons report a number of cases in which its application fails to achieve fistula closure. Here, we evaluate the fistula's physical properties during the vacuum assisted closure process in a computational approach exploring the relevance of intraluminal intestinal pressure.
   Methods: A mathematical model formulated by differential equations based on tissue elasticity properties and principles of fluid mechanics was created and forcing functions were integrated to mimic intestinal pressure dynamics. A software to solve equations and to fit the model to experimentally obtained data was developed. This enabled simulations of vacuum assisted fistula closure under different intestinal pressure.
   Results: The simulation output indicates conditions, in which fistula closure can or cannot be expected suggesting favoured or impeded healing, respectively. When modifications of intestinal pressure, as observed in fistula accompanying pathologies, are integrated, the outcome of fistula closure changes considerably. Rise of intestinal pressure is associated with delay of fistula closure and temporary fistula radius augmentation, while reduction of intestinal pressure during sub-atmospheric pressure treatment contributes to a faster and direct fistula closure.
   Conclusion: From the model predictions, we conclude that administration of intestinal pressure decreasing compounds (e. g. butylscopolamine, glucagon) may improve VAC treatment, while intestinal pressure increasing drugs should be avoided. (C) 2011 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [Cattoni, Diego I.] Univ Montpellier, CNRS, Ctr Biochim Struct, INSERM,U554,UMR 5048, F-34090 Montpellier, France.
   [Ravazzola, Constanza; Chara, Osvaldo] Univ Buenos Aires, Sch Med, Dept Physiol & Biophys, RA-1121 Buenos Aires, DF, Argentina.
   [Tuengler, Victoria] Charite Univ Med Berlin, Berlin, Germany.
   [Tuengler, Victoria] Tech Univ Dresden, Klin Kinder & Jugendmed, D-01307 Dresden, Germany.
   [Wainstein, Daniel E.] Gen Acute Hosp Dr E Tornu, RA-1427 Buenos Aires, DF, Argentina.
   [Chara, Osvaldo] Tech Univ Dresden, Ctr Informat Serv & High Performance Comp, D-01069 Dresden, Germany.
   [Chara, Osvaldo] UNLP, CONICET, Inst Phys Liquids & Biol Syst, RA-1900 La Plata, Argentina.
C3 Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Montpellier; University of
   Buenos Aires; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; Technische Universitat Dresden;
   Technische Universitat Dresden; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of La Plata
RP Chara, O (通讯作者)，Tech Univ Dresden, Room 1024,Nothnitzer Str 46, D-01187 Dresden, Germany.
EM osvaldo.chara@tu-dresden.de
RI Tüngler, Victoria/AAA-2396-2022; Chara, Osvaldo/T-2798-2019
OI Tüngler, Victoria/0000-0003-3486-2824; Chara,
   Osvaldo/0000-0002-0868-2507; Cattoni, Diego I/0000-0002-0048-8531
FU National Council for Scientific and Technical Research (CONICET) of
   Argentina; CONICET
FX Funding was provided by the National Council for Scientific and
   Technical Research (CONICET) of Argentina. O.C. is career researcher
   from Consejo Nacional de Investigaciones Cientificas y Tecnicas
   (CONICET) of Argentina. This work was supported by grants from CONICET.
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NR 34
TC 3
Z9 3
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PY 2011
VL 9
IS 8
BP 662
EP 668
DI 10.1016/j.ijsu.2011.09.001
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 890TJ
UT WOS:000300167800017
PM 21945673
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Maeda, S
   Sado, T
   Sakurada, A
   Okada, Y
   Kondo, T
AF Maeda, Sumiko
   Sado, Tetsu
   Sakurada, Akira
   Okada, Yoshinori
   Kondo, Takashi
TI Successful closure of an open-window thoracostomy wound by
   negative-pressure wound therapy: report of a case
SO SURGERY TODAY
LA English
DT Article
DE Chest wall abscess; Empyema; Negative-pressure wound therapy;
   Open-window thoracostomy; Wound healing
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; EMPYEMA;
   MANAGEMENT
AB Negative-pressure wound therapy is a newly developed, noninvasive technique to manage a wide variety of wounds. This novel therapy was successfully used to heal the wound after open-window thoracostomy without surgical closure. A 46-year-old woman was admitted to hospital because of a painful mass on the right side of her chest. Radiological findings revealed an abscess on the right chest wall that had ruptured into the right lung and caused empyema. Antibiotic therapy did not yield sufficient improvement. Open-window thoracostomy was performed to achieve a sterile pleural space, and negative-pressure wound therapy was then applied. The pleural space was reduced, and the patient was discharged home with self-administered wound care. The wound healed completely in 5 months without any need for surgical closure.
C1 [Maeda, Sumiko; Sado, Tetsu; Sakurada, Akira; Okada, Yoshinori; Kondo, Takashi] Tohoku Univ Hosp, Dept Thorac Surg, Aoba Ku, 4-1 Seiryomachi, Sendai, Miyagi 9808575, Japan.
C3 Tohoku University
RP Maeda, S (通讯作者)，Tohoku Univ Hosp, Dept Thorac Surg, Aoba Ku, 4-1 Seiryomachi, Sendai, Miyagi 9808575, Japan.
EM sumaeda-ths@umin.ac.jp
RI Yanaga, Katsuhiko/Y-6290-2019; Maeda, Sumiko/A-5628-2019
OI Yanaga, Katsuhiko/0000-0001-8918-4720; 
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   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Eyileten Z, 2009, SURG TODAY, V39, P947, DOI 10.1007/s00595-008-3982-5
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   Matzi V, 2007, ANN THORAC SURG, V84, P1762, DOI 10.1016/j.athoracsur.2007.05.052
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NR 14
TC 5
Z9 8
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD FEB
PY 2012
VL 42
IS 3
BP 295
EP 298
DI 10.1007/s00595-011-0008-5
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 892ZB
UT WOS:000300323200015
PM 22045234
DA 2026-07-24
ER
PT J
AU Karl, T
   Storck, M
AF Karl, T.
   Storck, M.
TI Negative pressure wound therapy. Importance within a differentiated
   treatment concept for femorodistal and inguinal vascular prosthesis
   infections
SO GEFASSCHIRURGIE
LA German
DT Article
DE Wound healing disorders in the perivascular region; Vascular surgery;
   Graft-preserving procedures; Alloplastic graft material; Negative
   pressure wound therapy (NPWT)
ID VACUUM-ASSISTED CLOSURE; GRAFT INFECTION; AUTOGENOUS RECONSTRUCTION;
   SURGICAL-MANAGEMENT; GROIN INFECTIONS; RIFAMPICIN; REPLACEMENT;
   RESISTANCE; BYPASS
AB Wound healing disorders in the perivascular region are a dangerous complication in vascular surgery. Despite many measures established in the past to prevent such infections, deep wound infections occur in up to 6% of cases. Especially if alloplastic material is used, not only the result of the arterial reconstruction but limb salvage and survival of the patient are critical due to life-threatening septic arrosion bleeding.
   Until a few years ago it was mandatory to completely explant alloplastic graft material in the case of deep infection involving the graft material, however, after the introduction of negative pressure wound therapy (NPWT) there are a growing number of reports available in the literature on successful graft-preserving procedures in cases of periprosthetic infections.
   It was the aim of this analysis of 29 own cases as well as of the literature to define a new classification of inguinal and femorodistal perivascular wound and/or graft infections, under the aspect of the availability of NPWT.
   The decision for graft preservation procedures should be based on the extent (depth) and localization of the infection, the type of bacterial infection and already existing complications. Complex stages, such as arrosion bleeding, anastomotic pseudoaneurysm and septic embolization require complete graft explantation, in less complicated cases graft-preserving procedures using NPWT can be justified.
C1 [Karl, T.] Klin Rotes Kreuz, Abt Gefass & Endovasc Chirurg, D-60316 Frankfurt, Germany.
   [Storck, M.] Stadt Klinikum Karlsruhe, Klin Gefass & Thoraxchirurg, Karlsruhe, Germany.
C3 Municipal Hospital Karlsruhe
RP Karl, T (通讯作者)，Klin Rotes Kreuz, Abt Gefass & Endovasc Chirurg, Konigswarterstr 16, D-60316 Frankfurt, Germany.
EM dr.t.karl@web.de
RI /L-6893-2017
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NR 52
TC 6
Z9 7
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0948-7034
EI 1434-3932
J9 GEFASSCHIRURGIE
JI Gefasschirurgie
PD FEB
PY 2012
VL 17
IS 1
BP 37
EP 44
DI 10.1007/s00772-011-0952-9
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 893AS
UT WOS:000300328000007
DA 2026-07-24
ER
PT J
AU Katz, MS
   Finck, CM
   Schwartz, MZ
   Moront, ML
   Prasad, R
   Timmapuri, SJ
   Arthur, LG
AF Katz, Michael S.
   Finck, Christine M.
   Schwartz, Marshall Z.
   Moront, Matthew L.
   Prasad, Rajeev
   Timmapuri, Shaheen J.
   Arthur, L. Grier
TI Vacuum-assisted closure in the treatment of extensive lymphangiomas in
   children
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 58th Annual Meeting of the British-Association-of-Paediatric-Surgeons
CY JUL 19-22, 2011
CL Belfast, NORTH IRELAND
SP British Assoc Paediat Surg
DE Lymphangioma; Cystic hygroma; Vacuum-assisted closure
ID PRESSURE WOUND THERAPY; LYMPHATIC MALFORMATIONS; SCLEROTHERAPY;
   FOUNDATION; EXPERIENCE
AB Background: The management of lymphangiomas in children is a complex problem with frequent recurrence and infection. Vacuum-assisted closure (VAC) devices have been shown to accelerate the healing of open wounds. We hypothesized that VAC therapy might decrease complications after resection of lymphangiomas.
   Methods: A retrospective review was performed on 13 children (August 2005 to April 2010) who were patients undergoing lymphangioma resection with postoperative VAC therapy. Patient demographics, size and location of the lymphangioma, VAC duration and number of changes, hospital stay, complications, need for further surgery, and length of follow-up were recorded.
   Results: Thirteen children (mean age, 8 years; mean weight, 34 kg) underwent 15 operations for lymphangiomas followed by postoperative VAC therapy. Locations included the head and neck, thorax and abdomen, and lower extremity. The mean VAC duration was 19 days, and they underwent a mean of 2.6 VAC changes. Six children had operative closure of the wound at a mean of 15 days postoperative. The remaining patients underwent closure by secondary intention. There were no recurrences. Complications included VAC device malfunctions requiring intervention and wound infections. Mean follow-up was 289 days.
   Conclusion: Postoperative VAC therapy for the treatment of lymphangiomas can be an effective adjunct to surgical treatment by decreasing risks of recurrence and infection. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Katz, Michael S.; Schwartz, Marshall Z.; Moront, Matthew L.; Prasad, Rajeev; Timmapuri, Shaheen J.; Arthur, L. Grier] Drexel Univ, Coll Med, St Christophers Hosp Children, Dept Pediat Gen Thorac & Minimally Invas Surg, Philadelphia, PA 19134 USA.
   [Finck, Christine M.] Univ Connecticut, Sch Med, Dept Pediat Surg, Connecticut Childrens Med Ctr, Hartford, CT 06112 USA.
C3 Drexel University; Connecticut Children's Medical Center; University of
   Connecticut
RP Arthur, LG (通讯作者)，Drexel Univ, Coll Med, St Christophers Hosp Children, Dept Pediat Gen Thorac & Minimally Invas Surg, Philadelphia, PA 19134 USA.
EM Grier.arthur@tenethealth.com
OI Finck, Christine/0000-0003-1771-7844
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NR 19
TC 19
Z9 20
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD FEB
PY 2012
VL 47
IS 2
BP 367
EP 370
DI 10.1016/j.jpedsurg.2011.11.030
PG 4
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Surgery
GA 894GR
UT WOS:000300415600025
PM 22325392
DA 2026-07-24
ER
PT J
AU Hlebowicz, J
   Hansson, J
   Lindstedt, S
AF Hlebowicz, Joanna
   Hansson, Johan
   Lindstedt, Sandra
TI Microvascular blood flow response in the intestinal wall and the omentum
   during negative wound pressure therapy of the open abdomen
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Negative pressure wound therapy; Open abdomen; Microvascular blood flow;
   Intestinal wall; Omentum
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL
   HYPERTENSION; MANAGEMENT; FISTULAS
AB Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) compared with other wound therapy techniques. However, the method has occasionally been associated with increased development of intestinal fistulae. The present study measures microvascular blood flow in the intestinal wall and the omentum before and during NPWT.
   Six pigs underwent midline incision and application of NPWT to the open abdomen. The microvascular blood flow in the underlying intestinal loop wall and the omentum was recorded before and after the application of NPWT of -50, -70, -100, -120, -150, and -170 mmHg respectively, using laser Doppler velocimetry.
   A significant decrease in microvascular blood flow was seen in the intestinal wall during application of all negative pressures levels. The blood flow was 2.7 (+/- 0.2) Perfusion Units (PU) before and 2.0 (+/- 0.2) PU (*p < 0.05) after application of -50 mmHg, and 3.6 (+/- 0.6) PU before and 1.5 (+/- 0.2) PU (**p < 0.01) after application of -170 mmHg.
   In the present study, we show that negative pressures between -50 and -170 mmHg induce a significant decrease in the microvascular blood flow in the intestinal wall. The decrease in blood flow increased with the amount of negative pressure applied. One can only speculate that a longstanding decreased blood flow in the intestinal wall may induce ischemia and secondary necrosis in the intestinal wall, which, theoretically, could promote the development of intestinal fistulae. We believe that NPWT of the open abdomen is a very effective treatment but could probably be improved.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, S-22185 Lund, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, Lund, Sweden.
   [Hlebowicz, Joanna; Lindstedt, Sandra] Skane Univ Hosp, Lund, Sweden.
   [Hansson, Johan] Uppsala Univ, Fac Med, Inst Surg Sci, Uppsala, Sweden.
   [Lindstedt, Sandra] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Lund
   University; Skane University Hospital; Uppsala University; Lund
   University
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, S-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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NR 34
TC 12
Z9 13
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD MAR
PY 2012
VL 27
IS 3
BP 397
EP 403
DI 10.1007/s00384-011-1317-2
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 895OX
UT WOS:000300507000016
PM 21938450
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Kasai, Y
   Nemoto, H
   Kimura, N
   Ito, Y
   Sumiya, N
AF Kasai, Yoshiaki
   Nemoto, Hitoshi
   Kimura, Naohiro
   Ito, Yoshinori
   Sumiya, Noriyoshi
TI Application of low-pressure negative pressure wound therapy to ischaemic
   wounds
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Low-pressure; Critical limb ischaemia
ID VACUUM-ASSISTED CLOSURE
AB Negative pressure wound therapy (NPWT) is a useful wound dressing that can be applied to a wide variety of wounds. Patients with ischaemic wounds, however, may experience further necrosis with NPWT at the commonly recommended pressure of -125 mm Hg. We hypothesized that with a suction pressure of -125 mm Hg, tissue pressure will likely occlude most of the capillaries adjacent to the wound edge. Therefore, we treated three patients with ischaemic wounds using low-pressure NPWT at -50 mm Hg. All wounds healed successfully without further necrosis at the wound edge. Crown Copyright (C) 2011 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons. All rights reserved.
C1 [Kasai, Yoshiaki; Nemoto, Hitoshi; Kimura, Naohiro; Ito, Yoshinori; Sumiya, Noriyoshi] Showa Univ, Sch Med, Fujigaoka Hosp, Dept Plast & Reconstruct Surg,Aoba Ku, Yokohama, Kanagawa 2278501, Japan.
C3 Showa Medical University
RP Kasai, Y (通讯作者)，Showa Univ, Sch Med, Fujigaoka Hosp, Dept Plast & Reconstruct Surg,Aoba Ku, 1-30 Fujigaoka, Yokohama, Kanagawa 2278501, Japan.
EM floatation-yoshi@nifty.com
OI Nemoto, Hitoshi/0000-0001-9043-1047
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Attinger CE, 2006, PLAST RECONSTR SURG, V117, p72S, DOI 10.1097/01.prs.0000225470.42514.8f
   Borgquist O, 2010, PLAST RECONSTR SURG, V125, P502, DOI 10.1097/PRS.0b013e3181c82e1f
   Castronuovo JJ, 1997, J VASC SURG, V26, P629, DOI 10.1016/S0741-5214(97)70062-4
   Isago T, 2003, J DERMATOL, V30, P596, DOI 10.1111/j.1346-8138.2003.tb00441.x
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Norgren L, 2007, EUR J VASC ENDOVASC, V33, pS5, DOI 10.1016/j.ejvs.2006.09.024
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
   Yamada T, 2008, J VASC SURG, V47, P318, DOI 10.1016/j.jvs.2007.10.045
NR 10
TC 15
Z9 18
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAR
PY 2012
VL 65
IS 3
BP 395
EP 398
DI 10.1016/j.bjps.2011.08.010
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 895VM
UT WOS:000300524800028
PM 21868297
DA 2026-07-24
ER
PT J
AU Yamasaki, O
   Nagao, Y
   Sugiyama, N
   Otsuka, M
   Iwatsuki, K
AF Yamasaki, Osamu
   Nagao, Yoh
   Sugiyama, Narushi
   Otsuka, Masaki
   Iwatsuki, Keiji
TI Surgical management of axillary necrotizing fasciitis: A case report
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE axilla; debridement; latissimus dorsi flap; Streptococcus pyogenes;
   toxic shock-like syndrome
ID CHEST-WALL
AB Axillary necrotizing fasciitis (NF) is quite rare and requires special management with respect to debridement and delayed surgical reconstruction. A 76-year-old man presented to our emergency department with a 2-day history of high fever, severe left axillary pain and redness. A few hours later, he developed discoloration and hemorrhagic bulla in the axilla, and the redness enlarged on the trunk. Emergency surgical debridement was performed. The blackish necrosis in the axilla was completely excised and the erythematous areas in the chest wall were cut down to the level of the fascia. Split-thickness skin grafts were applied during the second debridement on the 30th day of hospitalization and negative pressure wound therapy was used. Although the grafts took partially, full thickness axillary defects remained. We performed reconstruction with a pedicled latissimus dorsi flap on day 78. This case highlights some of the important surgical considerations in the management of axillary NF.
C1 [Yamasaki, Osamu] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Dermatol, Kita Ku, Okayama 7008558, Japan.
   [Sugiyama, Narushi] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Plast & Reconstruct Surg, Okayama Red Cross Hosp, Okayama 7008558, Japan.
C3 Okayama University; Okayama University
RP Yamasaki, O (通讯作者)，Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Dermatol, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
EM yamasa-o@cc.okayama-u.ac.jp
RI Yamasaki, Osamu/LZE-5515-2025
FU Grants-in-Aid for Scientific Research [23591646] Funding Source: KAKEN
CR Anaya DA, 2005, ARCH SURG-CHICAGO, V140, P151, DOI 10.1001/archsurg.140.2.151
   Basoglu M, 2007, SURG TODAY, V37, P558, DOI 10.1007/s00595-006-3391-6
   Brandstrom H, 1996, Lakartidningen, V93, P3687
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   Sarani B, 2009, J AM COLL SURGEONS, V208, P279, DOI 10.1016/j.jamcollsurg.2008.10.032
   Skitarelic N, 2003, INFECTION, V31, P39, DOI 10.1007/s15010-002-3057-2
   Urschel JD, 1997, ANN THORAC SURG, V64, P276, DOI 10.1016/S0003-4975(97)00514-6
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   Wong Chin-Ho, 2008, Am J Surg, V196, pe19, DOI 10.1016/j.amjsurg.2007.08.076
NR 10
TC 5
Z9 9
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0385-2407
J9 J DERMATOL
JI J. Dermatol.
PD MAR
PY 2012
VL 39
IS 3
BP 309
EP 311
DI 10.1111/j.1346-8138.2011.01456.x
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 897US
UT WOS:000300684500023
PM 22211460
DA 2026-07-24
ER
PT J
AU Burlew, CC
   Moore, EE
   Biffl, WL
   Bensard, DD
   Johnson, JL
   Barnett, CC
AF Burlew, Clay Cothren
   Moore, Ernest E.
   Biffl, Walter L.
   Bensard, Denis D.
   Johnson, Jeffrey L.
   Barnett, Carlton C.
TI One hundred percent fascial approximation can be achieved in the
   postinjury open abdomen with a sequential closure protocol
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 118th Scientific Session of the Western-Surgical-Association
CY NOV 07-10, 2010
CL Chicago, IL
SP Western Surg Assoc
DE Trauma; open abdomen; fascial closure; damage control surgery; delayed
   closure; abbreviated laparotomy
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM PACK TECHNIQUE; TRAUMA PATIENTS;
   WOUND CLOSURE; VENTRAL HERNIA; EXPERIENCE
AB BACKGROUND: Multiple techniques have been introduced to obtain fascial closure for the open abdomen. Vacuum-assisted closure has reduced but not eliminated the use of either split-thickness skin grafts to cover the exposed bowel or mesh (prosthetic or biological) approximation of the fascia. We hypothesized that a sequential closure technique performed by a systematic protocol would achieve a higher rate of primary fascial closure than other described techniques.
   METHODS: Our technique of sequential fascial closure was initiated in 2005. Patients with a postinjury open abdomen undergoing the technique were compared with those patients who did not follow the protocol. In brief, vacuum-assisted closure white sponges cover the bowel; the fascia is placed under moderate tension over the white sponges with no. 1-polydioxanone sutures; the black sponge is placed on top of this with the standard occlusive dressing; patients undergo partial fascial closure and replacement of the sponge sandwich every 2 days until completely closed. Protocol violations were defined as not returning to the operating room every other day and absence of fascial retention sutures. Patients who died before return to the operating room in the first 48 hours were excluded.
   RESULTS: One hundred consecutive patients underwent damage control surgery during the five-year study period and survived to second laparotomy; 49 patients attained fascial closure at the second laparotomy. Fifty-one patients required an open abdomen after the second laparotomy and comprise the study population. The majority were men (80%) with a mean age of 34.7 years +/- 2.0 years, mean injury severity score of 37.1 +/- 2.4, and mean abdominal trauma index of 26.4 +/- 2.1. Average initial base deficit was 15.7 +/- 0.6 and 24-hour red cell transfusions were 20.4 +/- 2.4 units. Of the 51 patients, 29 followed the protocol and 100% had fascial closure. Of the 22 patients who did not follow the protocol, 12 (55%) attained fascial closure. There were no significant differences in injury severity score, abdominal trauma index, base deficit, or red cell transfusions between the two groups.
   CONCLUSIONS: A methodical approach with sequential fascial closure achieves 100% fascial approximation in our experience. This technique reduces the morbidity of the open abdomen and the cost of either complex abdominal reconstruction or biological mesh insertion. (J Trauma. 2012;72: 235-241. Copyright (C) 2012 by Lippincott Williams & Wilkins)
C1 [Burlew, Clay Cothren] Denver Hlth Med Ctr, Dept Surg, Surg Intens Care Unit, Denver, CO 80204 USA.
   Univ Colorado, Denver, CO 80202 USA.
C3 Denver Health Medical Center; University of Colorado System; University
   of Colorado Denver
RP Burlew, CC (通讯作者)，Denver Hlth Med Ctr, Dept Surg, Surg Intens Care Unit, 777 Bannock St,MC 0206, Denver, CO 80204 USA.
EM clay.cothren@dhha.org
CR APRAHAMIAN C, 1990, J TRAUMA, V30, P719, DOI 10.1097/00005373-199006000-00011
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Barker DE, 2007, J AM COLL SURGEONS, V204, P784, DOI 10.1016/j.jamcollsurg.2006.12.039
   Bee TK, 2008, J TRAUMA, V65, P337, DOI 10.1097/TA.0b013e31817fa451
   Byrnes MC, 2010, AM J SURG, V199, P359, DOI 10.1016/j.amjsurg.2009.08.033
   Cipolla J, 2005, AM SURGEON, V71, P202
   Collier B, 2007, JPEN-PARENTER ENTER, V31, P410, DOI 10.1177/0148607107031005410
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   Stonerock CE, 2003, AM SURGEON, V69, P1030
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   Weinberg JA, 2008, J TRAUMA, V65, P345, DOI 10.1097/TA.0b013e31817fa489
NR 25
TC 56
Z9 60
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD JAN
PY 2012
VL 72
IS 1
BP 235
EP 241
DI 10.1097/TA.0b013e318236b319
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Surgery
GA 898IF
UT WOS:000300734800043
PM 22310132
DA 2026-07-24
ER
PT J
AU Heit, YI
   Dastouri, P
   Helm, DL
   Pietramaggiori, G
   Younan, G
   Erba, P
   Münster, S
   Orgill, DP
   Scherer, SS
AF Heit, Yvonne I.
   Dastouri, Pouya
   Helm, Douglas L.
   Pietramaggiori, Giorgio
   Younan, George
   Erba, Paolo
   Muenster, Stefan
   Orgill, Dennis P.
   Scherer, Sandra S.
TI Foam Pore Size Is a Critical Interface Parameter of Suction-Based Wound
   Healing Devices
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EXTRACELLULAR-MATRIX; CELL-PROLIFERATION; SKIN;
   ADHESION; MODEL
AB Background: Suction-based wound healing devices with open-pore foam interfaces are widely used to treat complex tissue defects. The impact of changes in physicochemical parameters of the wound interfaces has not been investigated.
   Methods: Full-thickness wounds in diabetic mice were treated with occlusive dressing or a suction device with a polyurethane foam interface varying in mean pore size diameter. Wound surface deformation on day 2 was measured on fixed tissues. Histologic cross-sections were analyzed for granulation tissue thickness (hematoxylin and eosin), myofibroblast density (alpha-smooth muscle actin), blood vessel density (platelet endothelial cell adhesion molecule-1), and cell proliferation (Ki67) on day 7.
   Results: Polyurethane foam-induced wound surface deformation increased with polyurethane foam pore diameter: 15 percent (small pore size), 60 percent (medium pore size), and 150 percent (large pore size). The extent of wound strain correlated with granulation tissue thickness that increased 1.7-fold in small pore size foam-treated wounds, 2.5-fold in medium pore size foam-treated wounds, and 4.9-fold in large pore size foam-treated wounds (p < 0.05) compared with wounds treated with an occlusive dressing. All polyurethane foams increased the number of myofibroblasts over occlusive dressing, with maximal presence in large pore size foam-treated wounds compared with all other groups (p < 0.05).
   Conclusions: The pore size of the interface material of suction devices has a significant impact on the wound healing response. Larger pores increased wound surface strain, tissue growth, and transformation of contractile cells. Modification of the pore size is a powerful approach for meeting biological needs of specific wounds. (Plast. Reconstr. Surg. 129: 589, 2012.)
C1 [Scherer, Sandra S.] Univ Lausanne Hosp, Dept Plast Surg, CH-1011 Lausanne, Switzerland.
   Harvard Univ, Brigham & Womens Hosp, Div Plast Surg, Sch Med, Cambridge, MA 02138 USA.
   Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University
RP Scherer, SS (通讯作者)，Univ Lausanne Hosp, Dept Plast Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM saja.scherer@googlemail.com
RI Münster, Stefan/D-6946-2011; Orgill, Dennis/H-7596-2019; PIETRAMAGGIORI,
   Giorgio/HJA-1920-2022
OI Münster, Stefan/0000-0002-8697-0344; Orgill, Dennis/0000-0002-8279-7310;
   Younan, George/0000-0001-8502-4850
FU Kinetic Concepts, Inc.
FX Dr. Orgill has been a consultant and an expert witness for Kinetic
   Concepts, Inc. (San Antonio, Texas), and a principal investigator on
   basic research studies on the vacuum-assisted closure device conducted
   through a grant to Brigham and Women's Hospital from Kinetic Concepts,
   Inc. The remaining authors have no financial disclosures to report.
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NR 17
TC 37
Z9 40
U1 0
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAR
PY 2012
VL 129
IS 3
BP 589
EP 597
DI 10.1097/PRS.0b013e3182402c89
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 900ZV
UT WOS:000300932300064
PM 22090246
DA 2026-07-24
ER
PT J
AU Schessel, ES
   Ger, R
   Oddsen, R
AF Schessel, Eli S.
   Ger, Ralph
   Oddsen, Robert
TI The Costs and Outcomes of Treating a Deep Pressure Ulcer in a Patient
   with Quadriplegia
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE pressure ulcer; quadriplegia; ischial; external tissue expanders
ID PREVENTION
AB The cost of pressure ulcers, especially Stage III and Stage IV ulcers, is substantial. A 27-year-old man with a 6-year history of quadriplegia developed an ischial pressure ulcer. Twelve months of treatment with wet-to-dry dressings were followed by admission to several facilities and 15 months of care with biological dressings and negative pressure wound therapy (NPWT). When admitted to the authors' wound care center, the wound measured 4.5 cm x 3.2 cm with exposed bone. A review of his insurance records showed that paid claims totaled $242,350, including $52,992 for NPWT rental costs. The patient was considered a good candidate for minimally invasive surgical intervention with external tissue expanders. Following a 14-day course of antibiotics to treat his infection, the wound was debrided and the tissue expanders applied. After 16 days, the wound was closed. The patient returned to work 6 weeks after the procedure. At the 23-month follow-up, the wound remained closed. Insurance payments for the care that resulted in wound closure totaled $43,814. This case study illustrates the potential of the external tissue expansion technique to close deep pressure ulcers within a relatively short amount of time at comparatively lower cost. Studies including control treatments are needed to confirm these conclusions.
C1 [Schessel, Eli S.] Flushing Hosp Med Ctr, Div Plast Surg, Flushing, NY USA.
RP Schessel, ES (通讯作者)，108-33 70th Rd,Forest Hills, New York, NY USA.
EM WoodWest3@aol.com
CR *AHCPR, AHCPR PUBL
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   US Department of Health and Human Services, PROF OLD AM 2009 ADM
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NR 18
TC 9
Z9 12
U1 1
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD FEB
PY 2012
VL 58
IS 2
BP 41
EP 46
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Surgery
GA 901LL
UT WOS:000300968300007
PM 22316632
DA 2026-07-24
ER
PT J
AU Bertheuil, N
   Aillet, S
   Heusse, JL
   Flecher, E
   Watier, E
AF Bertheuil, N.
   Aillet, S.
   Heusse, J. L.
   Flecher, E.
   Watier, E.
TI Large Necrosis: A Rare Complication of Medial Thighplasty
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Medial thighplasty; Skin necrosis; Bariatric surgery; Obesity
ID THIGH LIFT
AB Obesity is a major public health problem in Western societies. After failure of diet and exercise, patients can have bariatric surgery. Weight loss causes excess skin on the body, including the thighs. This leads to difficulty walking and psychological disorders such as devalued self-image. Medial thighplasty is an intervention to reduce excess skin and fat in the thighs. The main complications are scar migration, scar infection, hematoma, lymphedema, gaping vulva, and, rarely, skin necrosis. We describe a case of flap necrosis after a reoperation of medial thighplasty. Treatment included debridement of necrotic tissue and healing of the wound by secondary intention (vacuum-assisted closure and dressings with calcium alginate). Complete healing was achieved in 4 months. As the patient refused any new procedure, skin grafting was not performed. The aesthetic results of plastic surgery procedures are often imperfect. Patients should be clearly prepared and informed about the results expected from the operation. Surgeons should know contraindications for reoperation.
C1 [Bertheuil, N.; Aillet, S.; Heusse, J. L.; Flecher, E.; Watier, E.] Hosp Sud, Dept Plast Reconstruct & Aesthet Surg, F-35200 Rennes, France.
C3 CHU Rennes
RP Bertheuil, N (通讯作者)，Hosp Sud, Dept Plast Reconstruct & Aesthet Surg, 16 Blvd Bulgarie, F-35200 Rennes, France.
EM nbertheuil@gmail.com
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   Ellabban MG, 2004, BRIT J PLAST SURG, V57, P222, DOI 10.1016/j.bjps.2003.12.011
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NR 10
TC 3
Z9 5
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-216X
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD FEB
PY 2012
VL 36
IS 1
BP 88
EP 90
DI 10.1007/s00266-011-9752-6
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 901WY
UT WOS:000301000500014
PM 21607533
DA 2026-07-24
ER
PT J
AU Goudie, EB
   Gendics, C
   Lantis, JC
AF Goudie, Ewan B.
   Gendics, Cynthia
   Lantis, John C., II
TI Multimodal therapy as an algorithm to limb salvage in diabetic patients
   with large heel ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Clinics; Evidence; Infection; Wounds
ID QUALITY-OF-LIFE; PARTIAL CALCANECTOMY; FOOT; ULCERATIONS
AB In many series of diabetic foot ulcer care, heel ulcers greater than 4 cm across have been identified as an independent predictor of limb loss. Therefore, we set out to pursue the most aggressive limb salvage algorithm in patients with heel ulcers greater than 4 cm in diameter. Over 5 years, we identified 21 patients, 3984 years of age, all with diabetes mellitus, with heel ulcers greater than 4 cm in diameter and had magnetic resonance imaging or bone scan evidence of osteomyelitis. Seven of the 21 patients had end-stage renal disease defined as being haemodialysis dependent. All patients had ankle brachial indices <0./4 or monophasic pulse volume recordings. All patients underwent distal bypass surgery with vein. After adequate perfusion was obtained, all patients underwent partial calcanectomy and intra-operative negative pressure wound therapy (NPWT) placement. This was followed by treatment with recombinant platelet-derived growth factor (PDGF). One patient underwent amputation during the healing process secondary to ongoing sepsis. Twenty of 21 patients healed acutely (within 6 months). Three of 20 patients went on to subsequent below knee amputation within 12 months of healing primarily. At 2 years, 12 of 21 (57%) were ambulating independently, 1 of 21 was dead, 4 of 21 had undergone amputation, 4 (19%) had limbs that were intact but were not ambulating. A total limb salvage rate of 76% at 2 years mirrored the secondary patency rates, with 100% follow up. Heel ulcers require multimodality therapy if they are going to have any chance to heal. We believe the algorithm presented allows for the required revascularisation and a modulation of the heel ulcer microenvironment by augmenting the microcirculation through NPWT, and improving the proliferative capacity with PDGF.
C1 [Goudie, Ewan B.] Univ Edinburgh, Dept Orthopead, Edinburgh, Midlothian, Scotland.
   [Gendics, Cynthia; Lantis, John C., II] St Lukes Roosevelt Hosp, Div Vasc Surg, New York, NY USA.
C3 University of Edinburgh; Mount Sinai Morningside; Mount Sinai West
RP Lantis, JC (通讯作者)，St Lukes Roosevelt Hosp, 1090 Amsterdam Ave,Suite 7A, New York, NY 10024 USA.
EM jcl161@columbia.edu
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   [张力伟 Zhang Liwe], 2011, [混凝土, Concrete], P16
NR 27
TC 35
Z9 39
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2012
VL 9
IS 2
BP 132
EP 138
DI 10.1111/j.1742-481X.2011.00869.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 904WZ
UT WOS:000301230900006
PM 21951818
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Hansson, J
   Hlebowicz, J
AF Lindstedt, Sandra
   Hansson, Johan
   Hlebowicz, Joanna
TI Comparative study of the microvascular blood flow in the intestinal wall
   during conventional negative pressure wound therapy and negative
   pressure wound therapy using paraffin gauze over the intestines in
   laparostomy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Intestinal wall; Laparostomy; Microvascular blood flow; Negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME
AB Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) than with other kinds of wound management. We have recently shown that NPWT decreases the blood flow in the intestinal wall, and that the blood flow could be restored by inserting a protective disc over the intestines. The aim of the present study was to investigate whether layers of Jelonet (TM) (Smith & Nephew) dressing (paraffin tulle gras dressing made from open weave gauze) over the intestines could protect the intestines from hypoperfusion. Midline incisions were made in ten pigs and were subjected to treatment with NPWT with and without four layers of Jelonet over the intestines. The microvascular blood flow was measured in the intestinal wall before and after the application of topical negative pressures of -50, -70 and -120 mmHg, using laser Doppler velocimetry. Baseline blood flow was defined as 100% in all settings. The blood flow was significantly reduced, to 61 +/- 7% (P < 0.001), after the application of -50 mmHg using conventional NPWT, and to 62 +/- 7% (P < 0.001) after the application of -50 mmHg with Jelonet dressings between the dressing and the intestines. The blood flow was significantly reduced, to 38 +/- 5% (P < 0.001), after the application of -70 mmHg, and to 42 +/- 6% (P < 0.001) after the application of -70 mmHg with Jelonet dressings. The blood flow was significantly reduced, to 34 +/- 9% (P < 0.001), after the application of -120 mmHg, and to 38 +/- 6% (P < 0.001) after the application of -120 mmHg with Jelonet dressings. The use of four layers of Jelonet over the intestines during NPWT did not prevent a decrease in microvascular blood flow in the intestinal wall.
C1 [Lindstedt, Sandra] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Lindstedt, Sandra; Hlebowicz, Joanna] Skane Univ Hosp, Lund, Sweden.
   [Hansson, Johan] Uppsala Univ, Dept Surg Sci, Fac Med, Uppsala, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Uppsala
   University; Lund University
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473
CR Becker HP, 2007, SCAND J SURG, V96, P263, DOI 10.1177/145749690709600402
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NR 22
TC 12
Z9 13
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2012
VL 9
IS 2
BP 150
EP 155
DI 10.1111/j.1742-481X.2011.00871.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 904WZ
UT WOS:000301230900008
PM 21985421
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Egemen, O
   Ozkaya, O
   Ozturk, MB
   Aksan, T
   Orman, Ç
   Akan, M
AF Egemen, Onur
   Ozkaya, Ozay
   Ozturk, Muhammed Besir
   Aksan, Tolga
   Orman, Cagdas
   Akan, Mithat
TI Effective use of negative pressure wound therapy provides quick
   wound-bed preparation and complete graft take in the management of
   chronic venous ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chronic venous insufficiency; Chronic wound; Negative pressure wound
   therapy; Skin graft; Venous ulcer
ID VACUUM-ASSISTED CLOSURE; CHRONIC LEG ULCERS; EPIDEMIOLOGY;
   METALLOPROTEINASES; DRESSINGS; EFFICACY; SURGERY; TRIAL; STATE; SEPS
AB Venous ulcers are characterised by longstanding and recurrent loss of skin integrity. Once occurred, healing is slow and recurrence is high because of inappropriate conditions of the wound bed. This study involves 20 patients with chronic venous ulcers at least 6 weeks of duration treated with negative pressure wound therapy (NPWT). Patients underwent a radical debridement of all devitalised tissues in the first operation. After adequate haemostasis, silver-impregnated polyurethane foam was applied. Once the wounds were determined to be clean and adequate granulation tissue formation was achieved, split-thickness skin grafts were applied. Black polyurethane foam was applied over them. All wounds completely healed without the need for further debridement or regrafting. The mean number of silver-impregnated foam dressing changes prior to grafting was 2.9 (one to eight changes). The mean number of NPWT foam changes was 2.6 after skin grafting (two to five changes). Two patients who did not use conservative treatments for chronic venous insufficiency (CVI) after discharge from the hospital had recurrence of venous ulcers in the follow-up period. Application of NPWT provides quick wound-bed preparation and complete graft take in venous ulcer treatment.
C1 [Egemen, Onur; Ozkaya, Ozay; Ozturk, Muhammed Besir; Aksan, Tolga; Orman, Cagdas; Akan, Mithat] Okmeydani Educ & Res Hosp, Plast & Reconstruct Surg Clin, Istanbul, Turkey.
C3 Istanbul Okmeydani Training & Research Hospital
RP Egemen, O (通讯作者)，Atakoy 4 Kisim TO-80 Blok,D 7 34158 Bakirkoy, Istanbul, Turkey.
EM onuregemen@gmail.com
RI /AAM-6524-2020
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NR 50
TC 16
Z9 21
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2012
VL 9
IS 2
BP 199
EP 205
DI 10.1111/j.1742-481X.2011.00876.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 904WZ
UT WOS:000301230900012
PM 21992173
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Fraccalvieri, M
   Pristerà, G
   Zingarelli, E
   Ruka, E
   Bruschi, S
AF Fraccalvieri, Marco
   Pristera, Giuseppe
   Zingarelli, Enrico
   Ruka, Erind
   Bruschi, Stefano
TI Treatment of chronic heel osteomyelitis in vasculopathic patients. Can
   the combined use of Integra®, skin graft and negative pressure wound
   therapy be considered a valid therapeutic approach after partial
   tangential calcanectomy?
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Heel ulcers; Integra (R) Dermal Regeneration Template; Negative pressure
   wound therapy; Partial calcanectomy; Total calcanectomy
ID SURAL FLAP; OS CALCIS; RESECTION; FOOT; ULCERATIONS; EXPERIENCE;
   AMPUTATION
AB Osteomyelitis of the calcaneus is a difficult problem to manage. Patients affected by osteomyelitis of the calcaneus often have a below-the-knee amputation because of their comorbidity. In this article, we present seven cases of heel ulcerations with chronic osteomyelitis treated with Integra (R) Dermal Regeneration Template, skin graft and negative pressure wound therapy after partial tangential calcanectomy, discussing the surgical and functional results. In this casuistic of patients, all wounds healed after skin grating of the neodermis generated by Integra (R) with no patient requiring a below-knee amputation.
C1 [Fraccalvieri, Marco; Zingarelli, Enrico; Ruka, Erind; Bruschi, Stefano] Univ Turin, Dept Plast Reconstruct & Aesthet Surg, San Giovanni Battista Hosp, I-10126 Turin, Italy.
   [Pristera, Giuseppe] San Giovanni Battista Hosp, Dept Orthopaed Surg, Turin, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino; AOU San Giovanni
   Battista-Molinette; University of Turin; A.O.U. Citta della Salute e
   della Scienza di Torino; AOU San Giovanni Battista-Molinette
RP Fraccalvieri, M (通讯作者)，Univ Turin, Dept Reconstruct & Aesthet Plast Surg, San Giovanni Battista Molinette Hosp, Via Cherasco 23, I-10126 Turin, Italy.
EM marco@fraccalvieri.it
RI ; /AAF-4387-2019
OI Bruschi, Stefano/0000-0002-4746-9864; 
CR ANTONIOU D, 1974, J BONE JOINT SURG AM, VA 56, P338, DOI 10.2106/00004623-197456020-00014
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NR 19
TC 34
Z9 37
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2012
VL 9
IS 2
BP 214
EP 220
DI 10.1111/j.1742-481X.2011.00878.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 904WZ
UT WOS:000301230900014
PM 22050631
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Simek, M
   Hajek, R
   Fluger, I
   Molitor, M
   Grulichova, J
   Langova, K
   Tobbia, P
   Nemec, P
   Zalesak, B
   Lonsky, V
AF Simek, M.
   Hajek, R.
   Fluger, I.
   Molitor, M.
   Grulichova, J.
   Langova, K.
   Tobbia, P.
   Nemec, P.
   Zalesak, B.
   Lonsky, V.
TI Superiority of topical negative pressure over closed irrigation therapy
   of deep sternal wound infection in cardiac surgery
SO JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 58th Annual Meeting of the Scandinavian-Association-for-Thoracic-Surgery
   (SATS)
CY AUG 20-22, 2009
CL Stockholm, SWEDEN
SP Scandinavian Assoc Thorac Surg (SATS)
DE Wound infection; Negative-pressure wound therapy; Cardiac surgical
   procedures, complications
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; LONG-TERM SURVIVAL;
   POSTSTERNOTOMY MEDIASTINITIS; BLOOD-FLOW; STERNOTOMY; IMPACT; MANAGEMENT
AB Aim. We sought to compare clinical outcomes, in-hospital mortality and 1-year survival of two different treatment modalities of deep sternal wound infection, topical negative pressure and the closed irrigation therapy.
   Methods. Retrospective analysis of 66 consecutive patients treated for deep sternal infection at our institution. A total of 28 patients (February 2002 through September 2004) underwent primarily closed irrigation therapy, and 34 patients (November 2004 through December 2007) had the application of topical negative pressure. Four patients (July 2004 through December 2004) who underwent a combination of both strategies were excluded from the study. Clinical and wound care outcomes were compared, focusing on therapeutic failure rate, in-hospital stay and the 1-year mortality of both treatment strategies.
   Results. Topical negative pressure was associated with a significantly lower failure rate of the primary therapy (P<0.05), shortening of the intensive care unit stay (P<0.001), a particular decrease in the in-hospital stay (P<0.05) and the 1-year mortality (P<0.05) in comparison with closed irrigation therapy. Comparable overall length of the therapy, in-hospital stay and the risk of wire-related fistulas after chest reconstruction were found.
   Conclusion. Topical negative pressure is a superior method of treatment for deep sternal wound infection, which is based on lower therapeutic failure rate, significant decrease in-hospital stay, and the decrease of the 1-year mortality rate, compared with primarily applied closed irrigation.
C1 [Simek, M.; Hajek, R.; Fluger, I.; Grulichova, J.; Tobbia, P.; Nemec, P.; Lonsky, V.] Univ Hosp & Palacky Univ, Fac Med, Dept Cardiac Surg, Olomouc 77520, Czech Republic.
   [Molitor, M.; Zalesak, B.] Univ Hosp & Palacky Univ, Fac Med, Dept Plast & Reconstruct Surg, Olomouc 77520, Czech Republic.
   [Langova, K.] Univ Hosp & Palacky Univ, Fac Med, Inst Med Biophys, Olomouc 77520, Czech Republic.
C3 University Hospital Olomouc; Palacky University Olomouc; Palacky
   University Olomouc; University Hospital Olomouc; University Hospital
   Olomouc; Palacky University Olomouc
RP Simek, M (通讯作者)，Univ Hosp & Palacky Univ, Fac Med, Dept Cardiac Surg, IP Pavlova 6, Olomouc 77520, Czech Republic.
EM martin.simek@c-mail.cz
RI ; Molitor, Martin/AAF-8445-2021; Hajek, Roman/AAB-4232-2020
OI Šimek, Martin/0000-0001-5377-2096; Molitor, Martin/0000-0003-3843-9150; 
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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NR 25
TC 15
Z9 18
U1 0
U2 12
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0021-9509
EI 1827-191X
J9 J CARDIOVASC SURG
JI J. Cardiovasc. Surg.
PD FEB
PY 2012
VL 53
IS 1
BP 113
EP 120
PG 8
WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Surgery
GA 905KH
UT WOS:000301270600016
PM 22231537
DA 2026-07-24
ER
PT J
AU Gallo, O
   Deganello, A
   Meccariello, G
   Spina, R
   Peris, A
AF Gallo, Oreste
   Deganello, Alberto
   Meccariello, Giuseppe
   Spina, Rosario
   Peris, Adriano
TI Vacuum-assisted closure for managing neck abscesses involving the
   mediastinum
SO LARYNGOSCOPE
LA English
DT Article
DE Neck abscess; mediastinitis; vacuum-assisted closure; infection
ID DESCENDING NECROTIZING MEDIASTINITIS; MANAGEMENT; INFECTION; SEPSIS
AB A 57-year-old immunocompetent male patient with a deep neck abscess involving the mediastinum was referred to us following unsuccessful treatment at his local hospital with medical therapy and ultrasound-guided aspiration. After initial evaluation and resuscitation, a contrast-enhanced computed tomography (CT) scan was performed, and the patient was transferred for surgical drainage. A vacuum-assisted closure (VAC) device was used as a surgical drain to help prevent reaccumulation of the purulent collections. A repeat CT scan on day 3 confirmed the absence of residual pus in the mediastinum and in the neck spaces, and the VAC device was removed. Perfect healing of the deep tissues with successful mediastinal toilette was observed. The patient resumed oral meals on postoperative day 10, and 2 days later he was discharged. A 1-month follow-up CT again demonstrated the complete healing and absence of the neck abscess. This case illustrates the possibility of avoiding more extensive and life-threatening procedures, such as open thoracotomy, in the treatment of neck abscesses extending into the mediastinum, and highlights the utility of VAC in the management of deep neck abscesses. Laryngoscope, 2012
C1 [Gallo, Oreste; Deganello, Alberto; Meccariello, Giuseppe] Univ Florence, Acad Clin Otolaryngol & Head Neck Surg, Dept Surg Sci, I-50134 Florence, Italy.
   [Spina, Rosario; Peris, Adriano] Careggi Teaching Hosp, Anaesthesia & Intens Care Unit Emergency Dept, Florence, Italy.
C3 University of Florence; University of Florence; Azienda Ospedaliero
   Universitaria Careggi
RP Gallo, O (通讯作者)，Univ Florence, Acad Clin Otolaryngol & Head Neck Surg, Dept Surg Sci, Viale Morgagni 85, I-50134 Florence, Italy.
EM o.gallo@med.unifi.it
RI ; Meccariello, Giuseppe/K-5685-2016; DEGANELLO, ALBERTO/I-2742-2014
OI Gallo, Oreste/0000-0003-3426-7179; Meccariello,
   Giuseppe/0000-0001-7753-4615; DEGANELLO, ALBERTO/0000-0003-1008-7333
CR Andrews BT, 2008, ANN OTO RHINOL LARYN, V117, P298, DOI 10.1177/000348940811700410
   Batacchi S, 2009, CRIT CARE, V13, DOI 10.1186/cc8193
   Daramola OO, 2009, OTOLARYNG HEAD NECK, V141, P123, DOI 10.1016/j.otohns.2009.03.033
   Deganello A, 2009, ACTA OTORHINOLARYNGO, V29, P160
   Dellinger RP, 2008, CRIT CARE MED, V36, P296, DOI 10.1097/01.CCM.0000298158.12101.41
   Dhir K, 2009, LARYNGOSCOPE, V119, P54, DOI 10.1002/lary.20000
   DURANDY Y, 1989, J THORAC CARDIOV SUR, V97, P282
   Ferguson D A Jr, 1992, Microbios, V69, P53
   Huang TT, 2004, HEAD NECK-J SCI SPEC, V26, P854, DOI 10.1002/hed.20014
   Islam Asad, 2008, J Med Case Rep, V2, P368, DOI 10.1186/1752-1947-2-368
   Min HK, 2004, ANN THORAC SURG, V77, P306, DOI 10.1016/S0003-4975(03)01333-X
   Parhiscar A, 2001, ANN OTO RHINOL LARYN, V110, P1051, DOI 10.1177/000348940111001111
   Perez D, 2007, J AM COLL SURGEONS, V205, P586, DOI 10.1016/j.jamcollsurg.2007.05.015
   Saadi A, 2011, ANN THORAC SURG, V91, P1582, DOI 10.1016/j.athoracsur.2011.01.018
   Singhal P, 2008, HEART LUNG CIRC, V17, P124, DOI 10.1016/j.hlc.2007.08.004
   Wang LF, 2003, AM J OTOLARYNG, V24, P111, DOI 10.1053/ajot.2003.31
NR 16
TC 26
Z9 30
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0023-852X
J9 LARYNGOSCOPE
JI Laryngoscope
PD APR
PY 2012
VL 122
IS 4
BP 785
EP 788
DI 10.1002/lary.22403
PG 4
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA 911KD
UT WOS:000301714800016
PM 22252529
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Menn, ZK
   Lee, E
   Klebuc, MJ
AF Menn, Zachary K.
   Lee, Edward
   Klebuc, Michael J.
TI Acellular Dermal Matrix and Negative Pressure Wound Therapy: A
   Tissue-Engineered Alternative to Free Tissue Transfer in the Compromised
   Host
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE acellular; dermal; matrix; lower; extremity
ID MICROSURGICAL RECONSTRUCTION; INTEGRA; COMPLICATIONS; SURGERY
AB Free tissue transfer has revolutionized lower extremity reconstruction; however, its use in elderly patients with multiple medical problems can be associated with elevated rates of perioperative morbidity and mortality. This study evaluates the use of acellular dermal matrix (ADM) in conjunction with negative pressure wound therapy (NPWT) and delayed skin graft application as an alternative to free tissue transfer in this compromised population. Bilayer, ADM (Integra, Plainsboro, NJ) was used in conjunction with NPWT (Wound V. A. C, Kinetic Concepts Inc., San Antonio, TX) to achieve vascularized coverage of complex lower extremity wounds with denuded tendon and bone in elderly, medically compromised patients. Following incorporation, the matrix was covered with split-thickness skin graft. Four patients (age range, 50 to 76 years) with multiple medical comorbidities were treated with the above protocol. The average time to complete vascularization of the matrix was 29 days. Definitive closure with split-thickness skin graft was achieved in three patients and one wound healed by secondary intention. No medical or surgical complications were encountered and stable soft tissue coverage was achieved in all patients. This early experience suggests that dermal substitute and NPWT with delayed skin graft application can provide a reasonable tissue-engineered alternative to free tissue transfer in the medically compromised individual.
C1 [Menn, Zachary K.; Lee, Edward; Klebuc, Michael J.] Methodist Hosp, Inst Reconstruct Surg, Houston, TX 77030 USA.
C3 Houston Methodist
RP Klebuc, MJ (通讯作者)，6560 Fannin,Suite 2200, Houston, TX 77030 USA.
EM mklebuc@tmhs.org
CR Bocchi A, 2000, ANN PLAS SURG, V45, P284, DOI 10.1097/00000637-200045030-00011
   BURKE JF, 1981, ANN SURG, V194, P413, DOI 10.1097/00000658-198110000-00005
   Corradino B, 2010, J PLAST RECONSTR AES, V63, pE245, DOI 10.1016/j.bjps.2009.05.038
   Dantzer E, 2001, BRIT J PLAST SURG, V54, P659, DOI 10.1054/bjps.2001.3684
   El-Hadidy MR, 2003, EGYPT J PLAST RECONS, V27, P61, DOI [10.3727/096368914X678382, DOI 10.3727/096368914X678382]
   Howard MA, 2005, PLAST RECONSTR SURG, V116, P1659, DOI 10.1097/01.prs.0000187135.49423.9f
   Jones NF, 2007, PLAST RECONSTR SURG, V119, P2053, DOI 10.1097/01.prs.0000260591.82762.b5
   Lee LF, 2008, PLAST RECONSTR SURG, V121, P1256, DOI 10.1097/01.prs.0000304237.54236.66
   Moiemen NS, 2006, PLAST RECONSTR SURG, V117, p160S, DOI 10.1097/01.prs.0000222609.40461.68
   Molnar JA, 2004, PLAST RECONSTR SURG, V113, P1339, DOI 10.1097/01.PRS.0000112746.67050.68
   Moore C, 2003, BRIT J PLAST SURG, V56, P66, DOI 10.1016/S0007-1226(02)00413-7
   Park CA, 2009, ANN PLAS SURG, V62, P164, DOI 10.1097/SAP.0b013e31817d87cb
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Payne CE, 2009, J PLAST RECONSTR AES, V62, P393, DOI 10.1016/j.bjps.2007.09.015
NR 14
TC 28
Z9 31
U1 1
U2 8
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD FEB
PY 2012
VL 28
IS 2
BP 139
EP 143
DI 10.1055/s-0031-1289167
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 912DX
UT WOS:000301776000009
PM 21959551
DA 2026-07-24
ER
PT J
AU Colli, A
AF Colli, Andrea
TI First experience with a new negative pressure incision management system
   on surgical incisions after cardiac surgery in high risk patients
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE incision; wound healing; negative pressure wound therapy; cardiac
   surgery; median sternotomy
ID STERNAL WOUND COMPLICATIONS; VACUUM-ASSISTED CLOSURE; LONG-TERM
   SURVIVAL; BYPASS GRAFT-SURGERY; SITE INFECTIONS; THERAPY; MEDIASTINITIS;
   IMPACT; RESISTANCE; MORTALITY
AB Background: Sternal wound infection remains a serious potential complication after cardiac surgery. A recent development for preventing wound complications after surgery is the adjunctive treatment of closed incisions with negative pressure wound therapy. Suggested mechanisms of preventive action are improving the local blood flow, removing fluids and components in these fluids, helping keep the incision edges together, protecting the wound from external contamination and promoting incision healing. This work reports on our initial evaluation and clinical experience with the Prevena (TM) Incision Management System, a recently introduced new negative pressure wound therapy system specifically developed for treating closed surgical incisions and helping prevent potential complications. We evaluated the new treatment on sternal surgical incisions in patients with multiple co-morbidities and consequently a high risk for wound complications.
   Methods: The Prevena (TM) incision management system was used in 10 patients with a mean Fowler risk score of 15.1 [Range 8-30]. The negative pressure dressing was applied immediately after surgery and left in place for 5 days with a continuous application of -125 mmHg negative pressure. Wounds and surrounding skin were inspected immediately after removal of the Prevena (TM) incision management system and at day 30 after surgery.
   Results: Wounds and surrounding skin showed complete wound healing with the absence of skin lesions due to the negative pressure after removal of the Prevena (TM) dressing. No device-related complications were observed. No wound complications occurred in this high risk group of patients until at least 30 days after surgery.
   Conclusions: The Prevena (TM) system appears to be safe, easy to use and may help achieve uncomplicated wound healing in patients at risk of developing wound complications after cardiothoracic surgery.
C1 [Colli, Andrea] Hosp Badalona Germans Trias & Pujol, Dept Cardiac Surg, Badalona, Spain.
   [Colli, Andrea] Univ Padua, Cardiac Surg Unit, Dept Cardiol Thorac & Vasc Sci, Padua, Italy.
C3 Hospital Germans Trias i Pujol; University of Padua
RP Colli, A (通讯作者)，Hosp Badalona Germans Trias & Pujol, Dept Cardiac Surg, Badalona, Spain.
EM colli.andrea.bcn@gmail.com
RI Colli, Andrea/G-4858-2011
OI Colli, Andrea/0000-0003-2724-3961
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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   Pachowsky M, INT ORTHOP
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NR 32
TC 79
Z9 87
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD DEC 6
PY 2011
VL 6
AR 160
DI 10.1186/1749-8090-6-160
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 916KB
UT WOS:000302100400001
PM 22145641
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pachowsky, M
   Gusinde, J
   Klein, A
   Lehrl, S
   Schulz-Drost, S
   Schlechtweg, P
   Pauser, J
   Gelse, K
   Brem, MH
AF Pachowsky, Milena
   Gusinde, Johannes
   Klein, Andrea
   Lehrl, Siegfried
   Schulz-Drost, Stefan
   Schlechtweg, Philipp
   Pauser, Johannes
   Gelse, Kolja
   Brem, Matthias H.
TI Negative pressure wound therapy to prevent seromas and treat surgical
   incisions after total hip arthroplasty
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; OPEN FRACTURES; TRAUMA; MANAGEMENT; DEFECT;
   BONE
AB The purpose of this study was to evaluate the use of negative pressure wound therapy (NPWT) to improve wound healing after total hip arthroplasty (THA) and its influence on the development of postoperative seromas in the wound area.
   The study is a prospective randomised evaluation of NPWT in patients with large surgical wounds after THA, randomising patients to either a standard dressing (group A) or a NPWT (group B) over the wound area. The wound area was examined with ultrasound to measure the postoperative seromas in both groups on the fifth and tenth postoperative days.
   There were 19 patients randomised in this study. Ten days after surgery, group A (ten patients, 70.5 +/- 11.01 years of age) developed seromas with an average size of 5.08 ml and group B (nine patients, 66.22 +/- 17.83 years of age) 1.97 ml. The difference was significant (p = 0.021).
   NPWT has been used on many different types of traumatic and non traumatic wounds. This prospective, randomised study has demonstrated decreased development of postoperative seromas in the wound and improved wound healing.
C1 [Pachowsky, Milena; Gusinde, Johannes; Klein, Andrea; Schulz-Drost, Stefan; Gelse, Kolja; Brem, Matthias H.] Univ Erlangen Nurnberg, Dept Surg, Div Trauma Surg & Orthopaed Surg, D-91054 Erlangen, Germany.
   [Lehrl, Siegfried] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, D-91054 Erlangen, Germany.
   [Schlechtweg, Philipp] Univ Erlangen Nurnberg, Dept Radiol, D-91054 Erlangen, Germany.
   [Pauser, Johannes] Univ Erlangen Nurnberg, Dept Orthopaed Rhumatol, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Brem, MH (通讯作者)，Univ Erlangen Nurnberg, Dept Surg, Div Trauma Surg & Orthopaed Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM brem@bwh.harvard.edu
CR Brem MH, 2008, UNFALLCHIRURG, V111, P122, DOI 10.1007/s00113-007-1360-1
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NR 20
TC 162
Z9 193
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2695
J9 INT ORTHOP
JI Int. Orthop.
PD APR
PY 2012
VL 36
IS 4
BP 719
EP 722
DI 10.1007/s00264-011-1321-8
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 917JP
UT WOS:000302171000005
PM 21761149
OA Bronze
DA 2026-07-24
ER
PT J
AU Siciliano, RF
   Waisberg, DR
   Samano, MN
   Leite, PF
   Tuma, P
   Barreiro, GC
   Strabelli, TMV
AF Siciliano, Rinaldo Focaccia
   Waisberg, Daniel Reis
   Samano, Marcos Naoyuki
   Leite, Paulo Ferreira
   Tuma Junior, Paulo
   Barreiro, Guilherme Cardinali
   Varejao Strabelli, Tania Mara
TI Poststernotomy aspergillosis: successful treatment with voriconazole,
   surgical debridement and vacuum-assisted closure therapy
SO CLINICS
LA English
DT Article
ID PRACTICE GUIDELINES; OSTEOMYELITIS; INFECTIONS; DEEP
C1 [Siciliano, Rinaldo Focaccia; Varejao Strabelli, Tania Mara] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Infect Control Team,Heart Inst InCor, Sao Paulo, Brazil.
   [Waisberg, Daniel Reis; Samano, Marcos Naoyuki] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Div Thorac Surg,Heart Inst InCor, Sao Paulo, Brazil.
   [Leite, Paulo Ferreira] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Chron Coronary Dis Unit,Heart Inst InCor, Sao Paulo, Brazil.
   [Tuma Junior, Paulo; Barreiro, Guilherme Cardinali] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Div Plast Surg, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo
RP Siciliano, RF (通讯作者)，Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Infect Control Team,Heart Inst InCor, Sao Paulo, Brazil.
EM rinaldo_focaccia@uol.com.br
RI Samano, Marcos/B-8982-2012; Samano, Marcos/B-8982-2012; Waisberg, Daniel
   Reis/AAD-9783-2019; Strabelli, Tânia/B-1857-2015
OI Samano, Marcos/0000-0002-0602-0569; Waisberg, Daniel
   Reis/0000-0003-4284-0633; Strabelli, Tânia/0000-0003-1955-1008
CR Brunet F, 1996, J THORAC CARDIOV SUR, V111, P1200
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NR 14
TC 3
Z9 5
U1 0
U2 0
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PY 2012
VL 67
IS 3
BP 297
EP 299
DI 10.6061/clinics/2012(03)17
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 919WN
UT WOS:000302362900017
PM 22473415
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Guomundsdóttir, I
   Steingrimsson, S
   Guobjartsson, T
AF Guomundsdottir, Ingibjorg
   Steingrimsson, Steinn
   Guobjartsson, Tomas
TI Negative pressure wound therapy in Iceland - indication and outcome
SO LAEKNABLADID
LA Icelandic
DT Article
DE Negative pressure wound therapy (NPWT); wound infectons; indications;
   outcome; healing rate
ID VACUUM-ASSISTED CLOSURE; TRIAL; MULTICENTER; ULCERS
AB Introduction: Negative pressure wound therapy (NPWT) is a recent therapeutic option in wound healing, where a vacuum source is used to create sub-atmospheric pressure in the wound bed with airtight dressings. The aims were to study the indications for the use of NPWT in a whole country and evaluate the outcome of treatment.
   Material and methods: This was a retrospective study that included all patients that were treated with NPWT in Iceland between January and December 2008. Information on indication, duration and outcome of treatment was collected from patient charts. Factors that are known to affect wound healing, such as diabetes, smoking and age, were also registered.
   Results: During the 12 month study period a total of 65 NPWT-treatments were given to 56 patients; 35 (63%) males and 21 (37%) females, with an average age of 62 yrs (range; 8 - 93). The indications for treatment were: wound infection (40%), promotion of wound healing (42%) and keeping cavities open (19%). The lower limbs (26%) and chest area (25%) were the most common sites for treatment. Six patients died during the treatment period, none of them due to complications related to NPWT, and these patients were excluded from analysis of wound healing. In the other 59 treatments, 40 wounds (68%) healed successfully, but healing was incomplete in 19. Treatment related complications were recorded in 19 (32%) cases; wound pain (12%) and skin problems (11%) being the most common ones.
   Conclusion: NPWT has been used considerably in Iceland, especially for infected surgical wounds and chronic wounds. In two thirds of cases a complete wound healing was achieved, which must be regarded as a favorable outcome.
C1 [Guomundsdottir, Ingibjorg] Univ Iceland, Dept Vasc Surg, IS-101 Reykjavik, Iceland.
   [Steingrimsson, Steinn; Guobjartsson, Tomas] Univ Iceland, Landspitali Univ Hosp, IS-101 Reykjavik, Iceland.
   [Guobjartsson, Tomas] Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.
C3 University of Iceland; University of Iceland; Landspitali National
   University Hospital; University of Iceland
RP Guobjartsson, T (通讯作者)，Univ Iceland, Dept Vasc Surg, IS-101 Reykjavik, Iceland.
EM tomasgud@landspitali.is
RI Steingrimsson, Steinn/AAF-5475-2021
OI Steingrimsson, Steinn/0000-0001-8320-5607
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Attinger CE, 2006, PLAST RECONSTR SURG, V117, p72S, DOI 10.1097/01.prs.0000225470.42514.8f
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Moues C M, 2005, J Wound Care, V14, P224
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Petzina R, 2010, J THORAC CARDIOV SUR, V140, P1133, DOI 10.1016/j.jtcvs.2010.06.063
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Sjögren J, 2011, INTERACT CARDIOV TH, V12, P117, DOI 10.1510/icvts.2010.252668
   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 19
TC 1
Z9 2
U1 0
U2 3
PU LAEKNAFELAG ISLANDS-ICELANDIC MEDICAL ASSOC
PI KOPAVOGUR
PA HLIDASMARI 8, KOPAVOGUR, 200, ICELAND
SN 0023-7213
EI 1670-4959
J9 LAEKNABLADID
JI Laeknabladid
PD MAR
PY 2012
VL 98
IS 3
BP 149
EP 153
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 920FT
UT WOS:000302389800004
PM 22450519
OA gold
DA 2026-07-24
ER
PT J
AU Schibilsky, D
   Benk, C
   Haller, C
   Berchtold-Herz, M
   Siepe, M
   Beyersdorf, F
   Schlensak, C
AF Schibilsky, David
   Benk, Christoph
   Haller, Christoph
   Berchtold-Herz, Michael
   Siepe, Matthias
   Beyersdorf, Friedhelm
   Schlensak, Christian
TI Double tunnel technique for the LVAD driveline: improved management
   regarding driveline infections
SO JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Left ventricular assist device; Driveline; Exit site infection; Double
   tunnel technique; Vacuum-assisted closure therapy
AB A driveline exit site infection is a serious and common complication in long-term left ventricular assist device (LVAD) support. To reduce the incidence and severity of late driveline infections, we modified our surgical technique (double tunnel), and compared it to the conventional short and straight driveline tunnel technique (conventional). We analyzed 43 consecutive patients (37 HeartMate II; 6 Ventrassist) regarding late onset driveline exit site infections after using the surgical driveline tunnel technique after successful LVAD implantation. Of these 43 patients, 11 were treated with the conventional short and straight driveline tunnel technique (conventional), while 32 patients were treated with the modified long subfascial, C-shaped technique (double tunnel). We observed slightly fewer superficial driveline exit site infections in the double tunnel group, even though the difference was not statistically significant (0.638 vs. 1.148 infections/1,000 patient-days; P = 0.22). There were also insignificantly fewer surgical interventions because of exit site infections in the double tunnel group (0.159 vs. 0.581 revisions/1,000 patient-days; P = 0.18). The double tunnel technique offers more surgical options in the case of driveline exit site infections. Due to the long subfascial tunnel, the infected site can be separated from the new driveline exit site, and vacuum-assisted closure therapy can be applied to the infected area. In conclusion, we recommend using the double tunnel driveline technique because of the low infection rate and better treatment options in the case of driveline exit site infection.
C1 [Schibilsky, David; Schlensak, Christian] Univ Med Ctr Tubingen, Dept Thorac & Cardiovasc Surg, D-72076 Tubingen, Germany.
   [Benk, Christoph; Haller, Christoph; Berchtold-Herz, Michael; Siepe, Matthias; Beyersdorf, Friedhelm] Univ Med Ctr Freiburg, Dept Cardiovasc Surg, D-79106 Freiburg, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital; University of Freiburg
RP Schibilsky, D (通讯作者)，Univ Med Ctr Tubingen, Dept Thorac & Cardiovasc Surg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
EM david.schibilsky@med.uni-tuebingen.de;
   christian.schlensak@med.uni-tuebingen.de
RI Schibilsky, David/AAM-2187-2020; Siepe, Matthias/AAF-9846-2019;
   Beyersdorf, Friedhelm/AAK-3718-2020; Haller, Christoph/IQU-0577-2023
OI Schibilsky, David/0000-0002-7597-7778; Siepe,
   Matthias/0000-0003-3305-9343; Beyersdorf, Friedhelm/0000-0003-2975-2751;
   
CR Al-Hwiesh AK, 2007, SAUDI J KIDNEY DIS T, V18, P37
   FAVAZZA A, 1995, PERITON DIALYSIS INT, V15, P357
   KHANNA RK, 1995, J NEUROSURG, V83, P791, DOI 10.3171/jns.1995.83.5.0791
   Morshuis M, 2009, EUR J CARDIO-THORAC, V35, P1020, DOI 10.1016/j.ejcts.2008.12.033
   Nicolini F, 2009, EUR J CARDIO-THORAC, V35, P214, DOI 10.1016/j.ejcts.2008.11.003
   Pasque MK, 2002, ANN THORAC SURG, V74, P1267, DOI 10.1016/S0003-4975(02)03752-9
   PATRICK CC, 1992, INFECT IMMUN, V60, P1363, DOI 10.1128/IAI.60.4.1363-1367.1992
   Zierer A, 2007, ANN THORAC SURG, V84, P515, DOI 10.1016/j.athoracsur.2007.03.085
NR 8
TC 44
Z9 47
U1 0
U2 3
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1434-7229
EI 1619-0904
J9 J ARTIF ORGANS
JI J. Artif. Organs
PY 2012
VL 15
IS 1
BP 44
EP 48
DI 10.1007/s10047-011-0607-3
PG 5
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA 921VM
UT WOS:000302506200009
PM 21987183
DA 2026-07-24
ER
PT J
AU Patel, RM
   Nagle, DJ
AF Patel, Ronak M.
   Nagle, Daniel J.
TI Nonoperative Management of Scleroderma of the Hand With Tadalafil and
   Subatmospheric Pressure Wound Therapy: Case Report
SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME
LA English
DT Article
DE Negative pressure wound therapy; scleroderma
ID SYSTEMIC-SCLEROSIS; SILDENAFIL
AB Scleroderma, or systemic sclerosis (SS), is an autoimmune disease leading to ischemic fibrosis and widespread collagen deposition, invariably affecting the hands. Optimized medical management remains the mainstay of therapy for SS. Surgery can be considered in refractory or severely disabling cases. However, microvascular insufficiency and fibrosis can lead to wound complications and, ultimately, amputation. We present the case of a 61-year-old man with a known history of scleroderma who presented with pain, chronic infection, and ulcerations in the left hand. Initially, amputation seemed a reasonable intervention. After medical optimization with tadalafil, his ulcerations persisted. Instead of amputation, we applied a subatmospheric pressure wound therapy device to his hand. In 4 months, his wounds had healed, there was no evidence of infection, and no digits were amputated. (J Hand Surg 2012;37A:803-806. Copyright (C) 2012 by the American Society for Surgery of the Hand. All rights reserved.)
C1 [Patel, Ronak M.; Nagle, Daniel J.] Northwestern Univ, Feinberg Sch Med, Dept Orthopaed Surg, Chicago Ctr Surg Hand, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine
RP Patel, RM (通讯作者)，Northwestern Univ, Feinberg Sch Med, Dept Orthopaed Surg, Chicago Ctr Surg Hand, 401 E Ontario St,1707, Chicago, IL 60611 USA.
EM rmpatel7@gmail.com
CR Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   BARRY M, 1983, ARTHRITIS RHEUM, V26, P1041, DOI 10.1002/art.1780260816
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   Chung Lorinda, 2007, J Dtsch Dermatol Ges, V5, P460, DOI 10.1111/j.1610-0387.2007.06279.x
   Colglazier CL, 2005, J RHEUMATOL, V32, P2440
   Gore J, 2005, ANN RHEUM DIS, V64, P1387, DOI 10.1136/ard.2004.034488
   Kelm J, 2009, INT J MED SCI, V6, P241
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   Webb LX, 2001, UNFALLCHIRURG, V104, P918, DOI 10.1007/PL00002776
NR 16
TC 9
Z9 9
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0363-5023
EI 1531-6564
J9 J HAND SURG-AM
JI J. Hand Surg.-Am. Vol.
PD APR
PY 2012
VL 37A
IS 4
BP 803
EP 806
DI 10.1016/j.jhsa.2011.12.030
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 925JA
UT WOS:000302756300027
PM 22305739
DA 2026-07-24
ER
PT J
AU Narducci, F
   Samouelian, V
   Marchaudon, V
   Koenig, P
   Fournier, C
   Phalippou, J
   Leblanc, E
AF Narducci, Fabrice
   Samouelian, Vanessa
   Marchaudon, Valerie
   Koenig, Philippe
   Fournier, Charles
   Phalippou, Jerome
   Leblanc, Eric
TI Vacuum-assisted closure therapy in the management of patients undergoing
   vulvectomy
SO EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
LA English
DT Article
DE Vulvar cancer; Vulvectomy; Lymphadenectomy; Healing; Vacuum assisted
   closure
ID CANCER; COMPLICATIONS; CARCINOMA; TRENDS
AB Objectives: To investigate whether systematic postoperative VAC therapy could improve vulvectomy healing.
   Study design: We reviewed medical data from 54 women who underwent in the period of March 2006 to December 2009 radical vulvectomy or wide local vulvectomy with defect volume >40 cm(3). Patients were divided into two groups according to immediate postoperative care. Patients treated with systematic vacuum-assisted closure (VAC) therapy immediately after surgery were included in the "VAC group" while patients receiving conventional care (CC) were included in the "CC group".
   Results: The characteristics of the VAC group (n = 30) and CC group (n = 24) were similar and there were no significant differences in operative data, histological results or oncologic follow-up. The median length of use of VAC was 11 days after surgery (6-38). The length of hospital stay for patients in the VAC group and CC group was 17.8 (+/- 8.7) and 18.4 days (+/- 9.9) (p = 0.8) respectively. The lengths of complete healing were 44.4 (+/- 18.4) vs. 60.2 (+/- 28.7) days (p = 0.0175) respectively.
   Conclusions: In our study we proved that using VAC dressing immediately after vulvectomy (at least 6 cm x 7 cm) for 11 days reduces the total length of cicatrization by approximately 16 days. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Narducci, Fabrice; Samouelian, Vanessa; Marchaudon, Valerie; Koenig, Philippe; Fournier, Charles; Phalippou, Jerome; Leblanc, Eric] Ctr Oscar Lambret, Ctr Canc, F-59020 Lille, France.
C3 UNICANCER; Centre Oscar Lambret
RP Narducci, F (通讯作者)，Ctr Oscar Lambret, Ctr Canc, 3 Rue Frederic Combemale,BP 307, F-59020 Lille, France.
EM f-narducci@o-lambret.fr
OI Phalippou, Jerome/0000-0002-5396-7894; narducci,
   fabrice/0000-0001-5809-3535; leblanc, eric/0000-0001-7299-0339;
   PHALIPPOU, Jérôme/0000-0003-3779-6869
CR Ansink A, 2000, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD002036, DOI 10.1002/14651858.CD002036]
   Arvas M, 2005, INT J GYNECOL OBSTET, V88, P127, DOI 10.1016/j.ijgo.2004.10.004
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   de Hullu JA, 2006, EJSO-EUR J SURG ONC, V32, P825, DOI 10.1016/j.ejso.2006.03.035
   Gaarenstroom KN, 2003, INT J GYNECOL CANCER, V13, P522, DOI 10.1046/j.1525-1438.2003.13304.x
   Hoogerbrugge N, 2006, EUR J CANCER, V42, P2492, DOI 10.1016/j.ejca.2006.05.027
   McGuire P, 2000, ONCOLOGY
   Schimp VL, 2004, GYNECOL ONCOL, V92, P586, DOI 10.1016/j.ygyno.2003.10.055
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NR 10
TC 18
Z9 20
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-2115
J9 EUR J OBSTET GYN R B
JI Eur. J. Obstet. Gynecol. Reprod. Biol.
PD APR
PY 2012
VL 161
IS 2
BP 199
EP 201
DI 10.1016/j.ejogrb.2011.12.016
PG 3
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 925MN
UT WOS:000302765400016
PM 22252048
DA 2026-07-24
ER
PT J
AU Eisenhardt, SU
   Schmidt, Y
   Thiele, JR
   Iblher, N
   Penna, V
   Torio-Padron, N
   Stark, GB
   Bannasch, H
AF Eisenhardt, S. U.
   Schmidt, Y.
   Thiele, J. R.
   Iblher, N.
   Penna, V.
   Torio-Padron, N.
   Stark, G. B.
   Bannasch, H.
TI Negative pressure wound therapy reduces the
   ischaemia/reperfusion-associated inflammatory response in free muscle
   flaps
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Free flap surgery; Negative pressure wound therapy;
   Ischaemia/reperfusion injury
ID VACUUM-ASSISTED CLOSURE; ISCHEMIA-REPERFUSION INJURY; RAT SKIN FLAPS;
   ISCHEMIA/REPERFUSION INJURY; CONTROLLED-TRIAL; CELL-DEATH; LIVER;
   APOPTOSIS; MECHANISMS; FOUNDATION
AB Background: We recently established negative pressure wound therapy (NPWT) as a safe postoperative care concept for free muscle flaps; however, the molecular effects of NPWT on free muscle flaps remain elusive. Here we investigated the effects of NPWT on pathological changes associated with ischaemia/reperfusion injury in free flap tissue.
   Methods: From July 2008 to September 2010, 30 patients receiving skin-grafted free muscle transfer for defect coverage were randomly assigned to two treatment groups: In one group the skin-grafted free flap was covered by a vacuum dressing (NPWT); in the second group, flaps were covered by conventional petroleum gauze dressings (conv). Biopsies were taken intraoperatively prior to clipping of the pedicle and on postoperative day 5. Samples were analysed by immunohistochemistry for infiltration of inflammatory cells, real-time polymerase chain reaction (RT-PCR) for the analysis of expression levels of interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF)-alpha as markers of inflammation. Histological samples were also examined for interstitial oedema formation, and apoptosis was detected by a terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay.
   Results: NPWT leads to a significantly reduced tissue infiltration of CD68 + macrophages and reduced expression of the inflammatory cytokines IL-1 beta and TNF alpha. None of these parameters was significantly elevated in the pre-ischaemic biopsies. Furthermore, NPWT reduced the interstitial oedema formation and the number of apoptotic cells in free flap tissue.
   Conclusion: NPWT of skin-grafted free muscle flaps leads to a reduced inflammatory response following ischaemia/reperfusion, resulting in reduced oedema formation improving the microcirculation and ultimately reduced tissue damage. We thereby deliver new insight into the effects of NPWT. (C) 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Eisenhardt, S. U.; Schmidt, Y.; Thiele, J. R.; Iblher, N.; Penna, V.; Torio-Padron, N.; Stark, G. B.; Bannasch, H.] Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, D-79106 Freiburg, Germany.
C3 University of Freiburg
RP Eisenhardt, SU (通讯作者)，Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Hugstetter Str 55, D-79106 Freiburg, Germany.
EM steffen.eisenhardt@uniklinik-freiburg.de
RI Eisenhardt, Steffen Ulrich/AAF-8033-2021
OI Eisenhardt, Steffen Ulrich/0000-0003-4471-3160
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NR 43
TC 75
Z9 89
U1 0
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAY
PY 2012
VL 65
IS 5
BP 640
EP 649
DI 10.1016/j.bjps.2011.11.037
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 926XD
UT WOS:000302864300024
PM 22137686
DA 2026-07-24
ER
PT J
AU Beitz, JM
   van Rijswijk, L
AF Beitz, Janice M.
   van Rijswijk, Lia
TI Developing Evidence-Based Algorithms for Negative Pressure Wound Therapy
   in Adults with Acute and Chronic Wounds: Literature and Expert-based
   Face Validation Results
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE wounds; algorithms; negative pressure wound therapy; validation studies;
   evidence-based medicine/classification
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; PROSPECTIVE
   RANDOMIZED-TRIAL; SUBATMOSPHERIC PRESSURE; ABDOMINAL WOUNDS; OPEN
   ABDOMEN; POSTSTERNOTOMY MEDIASTINITIS; TEMPORARY TREATMENT; CARE
   ALGORITHMS; PALLIATIVE CARE
AB Negative pressure wound therapy (NPWT) is used extensively in the management of acute and chronic wounds, but concerns persist about its efficacy, effectiveness, and safety. Available guidelines and algorithms are wound type-specific, not evidence-based, and many lack clearly described relative and absolute contraindications and stop criteria. The purpose of this research was to: 1) develop evidence-based algorithms for the safe use of NPWT in adults with acute and chronic wounds by nonwound expert clinicians, and 2) obtain face validity for the algorithms. Using NPWT meta-analyses and systematic reviews (n = 10), NPWT guidelines of care (n = 12), general evidence-based guidelines of wound care (n = 11), and a framework for transitioning between moisture-retentive and NPWT care (n = 1), a set of three algorithms was developed. Literature-based validity for each of the 39 discreet algorithm steps/decision points was obtained by reviewing best available evidence from systematic literature reviews (n = 331 publications) and abstraction of all NPWT-relevant publications (n = 182) using the patient-oriented Strength of Recommendation (SORT) taxonomy. Of the 182 NPWT studies abstracted, 25 met criteria for level 1 and 2 evidence but only one general assessment step had both level 1 evidence and an "A" strength of recommendation. Next, an Institutional Review Board-approved, cross-sectional mixed methods survey design face validation pilot study was conducted to solicit comments on, and rate the validity of, the 51 discreet algorithm-related statements, including the 39 decisions/steps. Twelve (12) of the 15 invited interdisciplinary wound experts agreed to participate. The overall algorithm content validity index (CVI) was high (0.96 out of 1). Helpful design suggestions to ensure safe use were made, and participants suggested an examination of commonly used wound definitions in follow-up studies. Results of the literature-based face validation confirm that the evidence base for using NPWT remains limited, especially for chronic wounds, and that safety guidance may be affected by the fact that evidence-based ratings cannot accurately reflect relative or absolute product contraindications because they simply are not included in clinical studies. These findings, the positive expert panel comments, and the high CVI confirm the need for an algorithm with explicit NPWT start-and-stop criteria and suggest that follow-up content and construct validation of these algorithms is warranted.
C1 [Beitz, Janice M.] La Salle Univ, Sch Nursing & Hlth Sci, Philadelphia, PA 19141 USA.
   [van Rijswijk, Lia] Holy Family Univ, Ing & Allied Hlth Profess, Philadelphia, PA USA.
C3 La Salle University
RP Beitz, JM (通讯作者)，La Salle Univ, Sch Nursing & Hlth Sci, 1900 W Olney Ave, Philadelphia, PA 19141 USA.
EM beitz@lasalle.edu
RI vanRijswijk, Lia/LZF-6639-2025
FU ConvaTec, Inc (Skillman, NJ)
FX This study was supported by a research grant from ConvaTec, Inc
   (Skillman, NJ). The study was conducted, the data analyzed, and the
   manuscript written by the authors, who are responsible for the content
   of the publication. The authors do not have a financial interest in any
   of the products discussed.
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NR 199
TC 8
Z9 8
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD APR
PY 2012
VL 58
IS 4
BP 50
EP +
PG 19
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 927GF
UT WOS:000302894500010
PM 22466133
DA 2026-07-24
ER
PT J
AU Kadota, H
   Kakiuchi, Y
   Yoshida, T
AF Kadota, Hideki
   Kakiuchi, Yasunori
   Yoshida, Takamasa
TI Management of chylous fistula after neck dissection using
   negative-pressure wound therapy: A preliminary report
SO LARYNGOSCOPE
LA English
DT Article
DE Negative-pressure wound therapy; chylous fistula; neck dissection
ID VACUUM-ASSISTED CLOSURE; THORACIC-DUCT; SOMATOSTATIN; EXPERIENCE
AB Chylous fistula is a distressing complication resulting from thoracic duct injury during neck dissections. We have successfully managed chylous fistula using negative-pressure wound therapy (NPWT) in a case where all conservative treatments failed. A 60-year-old man with tongue cancer underwent subtotal glossectomy and bilateral neck dissections. On postoperative day 4, a chylous fistula with large drainage developed in the right neck. Conservative treatments were not effective, therefore, NPWT was started from postoperative day 9. The drainage volume then began to decrease, and the chylous fistula was closed 6 days after starting NPWT. In our case, the effects of wound shrinkage and fluid removal by NPWT were considered to contribute to early closure. Although preliminary, NPWT can be an important treatment choice for the management of a chylous fistula after neck dissections.
C1 [Kadota, Hideki] Okinawa Prefectural Chubu Hosp, Dept Plast & Reconstruct Surg, Uruma, Okinawa 9042293, Japan.
   [Kadota, Hideki; Kakiuchi, Yasunori; Yoshida, Takamasa] Sasebo Kyosai Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Sasebo, Nagasaki, Japan.
RP Kadota, H (通讯作者)，Okinawa Prefectural Chubu Hosp, Dept Plast & Reconstruct Surg, 281 Miyazato, Uruma, Okinawa 9042293, Japan.
EM hkadota@hotmail.co.jp
RI Kadota, Hideki/AAU-7710-2020
OI Kadota, Hideki/0000-0001-7833-3524; Yoshida,
   Takamasa/0000-0002-2946-9481
CR Abai B, 2007, J VASC SURG, V45, P610, DOI 10.1016/j.jvs.2006.10.043
   Andrews BT, 2008, ANN OTO RHINOL LARYN, V117, P298, DOI 10.1177/000348940811700410
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bollero D, 2007, WOUND REPAIR REGEN, V15, P589, DOI 10.1111/j.1524-475X.2007.00267.x
   deGier HHW, 1996, HEAD NECK-J SCI SPEC, V18, P347, DOI 10.1002/(SICI)1097-0347(199607/08)18:4<347::AID-HED6>3.0.CO;2-Y
   Dhir K, 2009, LARYNGOSCOPE, V119, P54, DOI 10.1002/lary.20000
   Ennker IC, 2009, J CARDIOTHORAC SURG, V4, DOI 10.1186/1749-8090-4-5
   Goverman J, 2006, J TRAUMA, V60, P428, DOI 10.1097/01.ta.0000203588.66012.c4
   Gregor RT, 2000, OTOLARYNG HEAD NECK, V122, P434, DOI 10.1016/S0194-5998(00)70061-1
   Harada A, 2010, Kyobu Geka, V63, P1039
   Lemaire V, 2008, EUR J VASC ENDOVASC, V36, P449, DOI 10.1016/j.ejvs.2008.04.002
   Orgill DP, 2011, PLAST RECONSTR SURG, V127, p105S, DOI 10.1097/PRS.0b013e318200a427
   Rollon A, 1996, INT J ORAL MAX SURG, V25, P363, DOI 10.1016/S0901-5027(06)80031-7
   Santaolalla F, 2010, EUR J CANCER CARE, V19, P510, DOI 10.1111/j.1365-2354.2009.01086.x
   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
   ULIBARRI JI, 1990, LANCET, V336, P258, DOI 10.1016/0140-6736(90)91793-A
   Valentine CN, 2002, HEAD NECK-J SCI SPEC, V24, P810, DOI 10.1002/hed.10103
NR 17
TC 26
Z9 31
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0023-852X
J9 LARYNGOSCOPE
JI Laryngoscope
PD MAY
PY 2012
VL 122
IS 5
BP 997
EP 999
DI 10.1002/lary.23216
PG 3
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA 927XY
UT WOS:000302945100012
PM 22447207
DA 2026-07-24
ER
PT J
AU Kieser, DC
   Roake, JA
   Hammond, C
   Lewis, DR
AF Kieser, D. C.
   Roake, J. A.
   Hammond, C.
   Lewis, D. R.
TI Negative pressure wound therapy as an adjunct to compression for healing
   chronic venous ulcers
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE topical negative pressure wound therapy; VAC; venous ulcers
ID VACUUM-ASSISTED CLOSURE
AB Objective: To determine the efficacy of negative pressure wound therapy (NPWT), when used in combination with compression bandaging, for healing chronic resistant venous ulcers.
   Method: In this pilot study, seven patients (with a total of I 2 chronic resistant venous ulcers) received adjunctive NPWT and compression bandaging for 4 weeks. Their wounds were monitored for a total of 12 weeks.
   Results: Dormant ulcers were seen to rapidly develop into healthy wounds, with a granulating base.
   Conclusion: This regimen may have a role in stimulating chronic venous ulcers into healing wounds, or in preparing them for skin grafting.
C1 [Kieser, D. C.] Dunedin Publ Hosp, Dunedin, New Zealand.
   [Roake, J. A.; Lewis, D. R.] Christchurch Hosp, Christchurch, New Zealand.
   [Hammond, C.] Nurse Maude Hosp & Hosp, Christchurch, New Zealand.
C3 Dunedin Public Hospital; Christchurch Hospital New Zealand
RP Kieser, DC (通讯作者)，Dunedin Publ Hosp, Dunedin, New Zealand.
EM kieserdavid@gmail.com
RI ; Hammond, Catherine/QMQ-8616-2026
OI Kieser, David/0000-0001-6060-6627; 
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
   Cullum N., 2006, COCHRANE DB SYST REV, V3
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   FALANGA V, 2002, CLIN RELEVANCE WOUND
   Furniss D., 2005, SURG WOUND INFECT RO
   Kaplan M, 2004, WOUNDS, P20
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   Loree S, 2004, J Wound Care, V13, P249
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Ubbink DT, 2008, COCHRANE DB SYST REV, V3
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
NR 11
TC 14
Z9 17
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2011
VL 20
IS 1
BP 35
EP 37
DI 10.12968/jowc.2011.20.1.35
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 928NU
UT WOS:000302990600006
PM 21278639
DA 2026-07-24
ER
PT J
AU Goutos, I
   Ghosh, SJ
AF Goutos, I.
   Ghosh, S. J.
TI Gauze-based negative pressure wound therapy as an adjunct to
   collagen-elatin dermal template resurfacing
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE dermal template; Matriderm; negative pressure
ID VACUUM-ASSISTED CLOSURE; INTEGRA ARTIFICIAL SKIN; CONTROLLED-TRIAL;
   DRESSINGS
AB Objective: To report the first case series of gauze-based negative pressure wound therapy (NPWT) as an adjunct to collagen-elastin dermal template resurfacing and provide a brief overview of the current knowledge and controversies regarding NPWT in association with dermal templates.
   Method: In this prospective study, patients undergoing single stage resurfacing with Matriderm (Dr Suwelack Skin & Health Care, Germany) between September 2007 and September 2008 at Stoke Mandeville Hospital were identified and followed up.A gauze-based NPWT system (VISTA) was used to secure the dermal template and split skin graft to the wound bed. Rates of epithelialisation, the patients' analgesic requirements and patient concordance with the device were all recorded.
   Results: In the 10 patients studied (7 males and 3 females) this modality of vacuum therapy was found to be effective in all cases for bolstering single stage collagen-elastin dermal templates onto wounds, and contributed to excellent rates of epithelialisation (mean: 94%, range: 70-100%). Additionally, patient concordance with the device was excellent and the costs associated with its use were much lower compared with foam-based NPWT.
   Conclusion: We recommend the consideration of gauze-based NPWT as cost-effective alternative to foam based modalities in association with the use of dermal templates.
C1 [Goutos, I.; Ghosh, S. J.] Stoke Mandeville Hosp, Dept Plast Surg, Aylesbury HP21 8AL, Bucks, England.
RP Goutos, I (通讯作者)，Stoke Mandeville Hosp, Dept Plast Surg, Aylesbury HP21 8AL, Bucks, England.
EM ioannisgoutos@hotmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baldwin C, 2009, ANN PLAS SURG, V62, P92, DOI 10.1097/SAP.0b013e31817762fd
   BURKE JF, 1981, ANN SURG, V194, P413, DOI 10.1097/00000658-198110000-00005
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   Chang KP, 2001, BURNS, V27, P839, DOI 10.1016/S0305-4179(01)00052-3
   CHARIKER M E, 1989, Contemporary Surgery, V34, P59
   Clayton MC, 1998, J BURN CARE REHABIL, V19, P358, DOI 10.1097/00004630-199807000-00017
   DEVRIES HJC, 1995, BRIT J DERMATOL, V132, P690
   Greene AK, 2006, ANN PLAS SURG, V56, P418, DOI 10.1097/01.sap.0000202831.43294.02
   Haslik W, 2010, J PLAST RECONSTR AES, V63, P360, DOI 10.1016/j.bjps.2008.09.026
   Iusupov Iu N, 1987, Vestn Khir Im I I Grek, V138, P42
   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Malmsio M, 2008, SIMILAR PHYS PROPERT
   Malmsio M., 2008, NEGATIVE PRESSURE WO
   McCord SS, 2007, WOUND REPAIR REGEN, V15, P296, DOI 10.1111/j.1524-475X.2007.00229.x
   McEwan W, 2004, BURNS, V30, P259, DOI 10.1016/j.burns.2003.11.011
   Miller MS, 2005, OSTOMY WOUND MANAG, V51, P44
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Molnar JA, 2004, PLAST RECONSTR SURG, V113, P1339, DOI 10.1097/01.PRS.0000112746.67050.68
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Moues C M, 2005, J Wound Care, V14, P224
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Stiefel D, 2009, J PEDIATR SURG, V44, P575, DOI 10.1016/j.jpedsurg.2008.07.006
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 25
TC 6
Z9 7
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2011
VL 20
IS 2
BP 55
EP +
DI 10.12968/jowc.2011.20.2.55
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 929YV
UT WOS:000303102700003
PM 21378679
DA 2026-07-24
ER
PT J
AU Bondokji, S
   Rangaswamy, M
   Reuter, C
   Farajalla, Y
   Mole, T
   Cockwill, J
   Smith, J
AF Bondokji, S.
   Rangaswamy, M.
   Reuter, C.
   Farajalla, Y.
   Mole, T.
   Cockwill, J.
   Smith, J.
TI Clinical efficacy of a new variant of a foam-based NWPT system
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; polyurethane foam; wound dimensions;
   granulation tissue
ID VACUUM-ASSISTED CLOSURE; PRESSURE-WOUND-THERAPY; RANDOMIZED
   CONTROLLED-TRIAL; MULTICENTER; ULCERS; GAUZE
AB Objective: To evaluate the clinical efficacy of a new variant of a foam-based negative wound pressure wound therapy (NPWT) system.
   Method:A newly available polyurethane foam-based NPWT system (RENASYS-F, Smith & Nephew) was used to treat 18 patients in a prospective, multi-centre study.The patients had a variety of wound types including pressure ulcers, diabetic foot ulcers, traumatic and surgical wounds.
   Results: The mean patient age was 48.3 years (range 25-72). Mean treatment duration was 14.6 days (range 5-29).At the end of therapy, 83% (15) wounds had progressed sufficiently, leading to a change in treatment from NPWT. Median reductions in wound area, depth and volume of 31.3%, 45.5% and 74.2% respectively were observed over the course of therapy.This equated to a weekly reduction in area, depth and volume of 12.9%, 20.0% and 32.1% respectively. Exudate level (p=0.013) and wound malodour (p=0.03) were significantly reduced between the onset and the end of NPWT.The percentage cover of 'beefy' red granulation tissue in the wound bed was significantly increased (p<0.001) and non-viable tissue significantly reduced (p=0.008) between the onset and the end of NPWT.
   Conclusion: These data demonstrate that an alternative foam-based NPWT system (RENASYS-F) is able to address the common treatment goals associated with application of NPWT including reduction in wound dimensions, reduction in exudate levels and an improvement in wound bed quality.
C1 [Bondokji, S.] Int Med Ctr, Jeddah, Saudi Arabia.
   [Rangaswamy, M.] Welcare Hosp, Dubai, U Arab Emirates.
   [Reuter, C.] Al Mafraq Hosp, Abu Dhabi, U Arab Emirates.
   [Farajalla, Y.] Dubai Hosp, Dubai, U Arab Emirates.
   [Mole, T.; Cockwill, J.; Smith, J.] Smith & Nephew, Adv Wound Devices, Kingston Upon Hull, N Humberside, England.
C3 Dubai Hospital; Smith & Nephew
RP Bondokji, S (通讯作者)，Int Med Ctr, Jeddah, Saudi Arabia.
EM Jennifer.Smith@smith-nephew.com
FU Smith Nephew
FX Funding for this study was provided by Smith & Nephew. Authors TM, JC
   and JS are all employees of Smith & Nephew.
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Bollero D, 2007, WOUND REPAIR REGEN, V15, P589, DOI 10.1111/j.1524-475X.2007.00267.x
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   DeFranzo AJ, 2008, PLAST RECONSTR SURG, V121, P832, DOI 10.1097/01.prs.0000299268.51008.47
   Etoz A, 2007, WOUNDS, V19, P250
   Joseph E, 2000, WOUNDS, V12, P60
   Lee Hyun-Joo, 2009, J Orthop Surg Res, V4, P14, DOI 10.1186/1749-799X-4-14
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Malmsjö M, 2009, ANN PLAS SURG, V63, P676, DOI 10.1097/SAP.0b013e31819ae01b
   Malmsjö M, 2009, WOUND REPAIR REGEN, V17, P200, DOI 10.1111/j.1524-475X.2009.00461.x
   McCord SS, 2007, WOUND REPAIR REGEN, V15, P296, DOI 10.1111/j.1524-475X.2007.00229.x
   Mody GN, 2008, OSTOMY WOUND MANAG, V54, P36
   Sadat U, 2008, J Wound Care, V17, P45
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 15
TC 9
Z9 10
U1 0
U2 11
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2011
VL 20
IS 2
BP 62
EP +
DI 10.12968/jowc.2011.20.2.72
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 929YV
UT WOS:000303102700004
PM 21378681
DA 2026-07-24
ER
PT J
AU Vaughn, CJ
   Lalikos, JF
AF Vaughn, C. J.
   Lalikos, J. F.
TI The use of acellular dermal regeneration template for recalcitrant
   pilonidal disease
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE pilonidal sinus disease; vacuum-assisted closure; integra; dermal
   regeneration template
ID VACUUM-ASSISTED CLOSURE; SURGERY; THERAPY; SINUS
AB Numerous techniques have been described for the treatment of pilonidal disease, yet there remains no consensus on the optimal management of recurrent pilonidal disease. Pilonidal wounds often lack the structural integrity to heal over and Integra provides a scaffold for the regrowth of an autogenous dermis from the patient's own fibroblasts and collagen. Postoperative negative pressure wound therapy (NPWT) may speed vascularisation of Integra, re-epithelialisation, and wound closure. This case report concerns two patients with chronic pilonidal sinuses who underwent wide excision and placement of Integra with postoperative NPWT. Postoperatively, the patients were assessed for complications and recurrence. Both patients went on to heal and did not require further surgical treatment after a median follow-up of 29 months. Integra may help prevent pocket or cyst formation during the closure process and provides a neodermis, allowing for full re-epithelialisation. More research and a longer follow-up are needed to evaluate the role of Integra and NPWT in recurrent pilonidal disease.
C1 [Vaughn, C. J.; Lalikos, J. F.] Univ Massachusetts, Sch Med, Dept Surg, Div Plast Surg, Worcester, MA 01610 USA.
C3 University of Massachusetts System; University of Massachusetts
   Worcester
RP Vaughn, CJ (通讯作者)，Univ Massachusetts, Sch Med, Dept Surg, Div Plast Surg, Worcester, MA 01610 USA.
EM cjvaughn3@gmail.com
CR Bendewald FR, 2007, OSTOMY WOUND MANAG, V53, P40
   Eiinnebosel M., 2009, WORLD J SURG, V33, P130
   Holzer B, 2003, Colorectal Dis, V5, P222, DOI 10.1046/j.1463-1318.2003.00471.x
   Ichioka S, 2003, ANN PLAS SURG, V51, P383, DOI 10.1097/01.SAP.0000067971.90978.8F
   Lynch JB, 2004, DIS COLON RECTUM, V47, P929, DOI 10.1007/s10350-004-0522-2
   Matino James J, 2010, Conn Med, V74, P393
   McGuinness JG, 2003, DIS COLON RECTUM, V46, P274, DOI 10.1007/s10350-004-6535-z
   Moiemen NS, 2006, PLAST RECONSTR SURG, V117, p160S, DOI 10.1097/01.prs.0000222609.40461.68
NR 8
TC 4
Z9 4
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2011
VL 20
IS 6
BP 275
EP 277
DI 10.12968/jowc.2011.20.6.275
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 929YZ
UT WOS:000303103100003
PM 21727876
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Ingemansson, R
AF Malmsjo, M.
   Ingemansson, R.
TI Green foam, black foam or gauze for NWPT: effects on granulation tissue
   formation
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE experimental surgery; wound healing; negative pressure wound therapy;
   granulation tissue formation
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; NEGATIVE-PRESSURE;
   DRESSING CHANGES
AB Objective: To compare the effects of green foam with black foam and gauze during negative pressure wound therapy (NPWT), with regard to wound bed appearance and granulation tissue formation, and monitoring of wound exudate.
   Method: Wounds on the backs of eight pigs underwent 72 hours of NPWT plus either green polyurethane foam with an open pore structure, black polyurethane foam with an open pore structure or saline-moistened AMD gauze. Sections of biopsies from the wound bed, including the overlying dressing, were examined histologically with regard to microdeformation of the wound bed and granulation tissue formation. The force required to remove the wound fillers was measured.
   Results: Wound exudate and bleeding could be easily seen when using gauze and green foam, but were not visible under the black foam. Such visibility facilitates monitoring of the wound status. No difference was found in the quantity or characteristics of the granulation tissue formed under the green foam or black foam. Both green foam and black foam resulted in more pronounced granulation tissue formation than gauze under negative pressure. There was also more leucocyte infiltration and tissue disorganisation under green foam and black foam than under gauze. All three wound fillers created microdeformation within the wound bed surface. Similar forces were required to remove green foam and black foam (5.0 +/- 0.6 N for green foam and 4.0 +/- 0.4 N for black foam), while less force was needed for gauze (2.1 +/- 0.2 N). This may be a result of tissue ingrowth into the foam (357 +/- 12 mu m for green foam and 362 +/- 14 mu m for black foam), but not into gauze (0 mu m), as shown by examination of biopsy sections from the wound bed.
   Conclusion: Green foam and black foam have similar biological effects on the wound bed. Bleeding and exudate can be more easily monitored when using green foam or gauze. Differences in the wound bed tissue morphology when using foam or gauze plus NPWT support clinical observations that granulation tissue under foam is thick but fragile, whereas that under foam is thinner but denser.
C1 [Malmsjo, M.] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Ingemansson, R.] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Ingemansson, R.] Skane Univ Hosp, Lund, Sweden.
C3 Lund University; Lund University; Lund University; Skane University
   Hospital
RP Malmsjö, M (通讯作者)，Lund Univ, Dept Ophthalmol, Lund, Sweden.
EM malin.malmsjo@med.lu.se
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599
FU Molnlycke Health Care AB
FX The study was supported by Molnlycke Health Care AB.
CR Bollero D, 2007, WOUND REPAIR REGEN, V15, P589, DOI 10.1111/j.1524-475X.2007.00267.x
   Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
   Borgquist O, 2009, WOUNDS, V21, P302
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   Chariker ME, 2009, PLAST RECONSTR SURG, V123, P1510, DOI 10.1097/PRS.0b013e3181a20563
   Dunbar A, 2005, OSTOMY WOUND MANAG, V51, P18
   Evans D, 2001, BRIT J PLAST SURG, V54, P238, DOI 10.1054/bjps.2001.3547
   Fraccalvieri M., 2011, INT WOUND J IN PRESS, V12
   Franczyk M, 2009, PLAST RECONSTR SURG, V124, P854, DOI 10.1097/PRS.0b013e3181b038b4
   Greene AK, 2006, ANN PLAS SURG, V56, P418, DOI 10.1097/01.sap.0000202831.43294.02
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Paglinawan R, 2008, COMP STUDY INFLUENCE
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Wilkes R, 2009, J BIOMECH ENG-T ASME, V131, DOI 10.1115/1.2947358
   Zannis J, 2009, ANN PLAS SURG, V62, P407, DOI 10.1097/SAP.0b013e3181881b29
NR 20
TC 13
Z9 17
U1 0
U2 9
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2011
VL 20
IS 6
BP 294
EP 299
DI 10.12968/jowc.2011.20.6.294
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 929YZ
UT WOS:000303103100008
PM 21727880
DA 2026-07-24
ER
PT J
AU Rocco, G
   Cecere, C
   La Rocca, A
   Martucci, N
   Salvi, R
   Passera, E
   Cicalese, M
AF Rocco, Gaetano
   Cecere, Ciriaco
   La Rocca, Antonello
   Martucci, Nicola
   Salvi, Rosario
   Passera, Eliseo
   Cicalese, Marcellino
TI Caveats in using vacuum-assisted closure for post-pneumonectomy empyema
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Vacuum assisted closure; Pneumonectomy; Empyema; Bronchopleural fistula
ID BRONCHOPLEURAL FISTULA; MANAGEMENT; DEVICE
AB Vacuum-assisted closure (VAC) of chronic empyemas can potentially set challenging patients free of prolonged hospitalization by warranting outpatient care. We wanted to test this concept in post-pneumonectomy empyema patients.
   Three patients with post-pneumonectomy bronchopleural fistula were subjected to open window thoracostomy (OWT) and subsequently to VAC. The BPFs were closed by endobronchial stents in 2 of the patients. The VAC system was applied at a median time of 35 days (range, 23-113) after pneumonectomy. The patients were scheduled for outpatient visits every three days with complete change of the VAC sponges.
   Hypotension and acute thoracic pain despite minimal suction applied to the VAC sponges were observed during treatment and eventually caused VAC discontinuation. In one patient, the sponges of the VAC system could not be directly removed through the OWT and careful dissection through VATS under deep sedation was needed.
   VAC can be of help to obliterate the post-pneumonectomy empyema cavity but its use can trigger clinically significant complications. Cautious monitoring of the VAC system must be exercised in the early period prior to discharging patients to the outpatient clinic.
C1 [Rocco, Gaetano; La Rocca, Antonello; Martucci, Nicola; Salvi, Rosario; Passera, Eliseo; Cicalese, Marcellino] Pascale Fdn, Natl Canc Inst, Dept Thorac Surg & Oncol, Div Thorac Surg, I-80131 Naples, Italy.
   [Cecere, Ciriaco] Univ Naples Federico 2, Dept Thorac Surg, Naples, Italy.
C3 IRCCS Fondazione Pascale; University of Naples Federico II
RP Rocco, G (通讯作者)，Pascale Fdn, Natl Canc Inst, Dept Thorac Surg & Oncol, Div Thorac Surg, Via Semmola 81, I-80131 Naples, Italy.
EM gaetano.rocco@btopenworld.com
RI Rocco, Gaetano/K-4801-2016
OI Rocco, Gaetano/0000-0003-4150-8604
CR Aru GM, 2010, ANN THORAC SURG, V90, P266, DOI 10.1016/j.athoracsur.2010.04.092
   Hazelrigg Stephen R, 2010, Ann Thorac Surg, V90, P270, DOI 10.1016/j.athoracsur.2010.05.026
   Jones NC, 2006, ANN THORAC SURG, V81, P364, DOI 10.1016/j.athoracsur.2004.09.054
   Massera F, 2006, ANN THORAC SURG, V82, P288, DOI 10.1016/j.athoracsur.2005.11.046
   Passera E, 2011, ANN THORAC SURG, V92, pE23, DOI 10.1016/j.athoracsur.2011.03.047
   Schneiter D, 2008, J THORAC CARDIOV SUR, V136, P179, DOI 10.1016/j.jtcvs.2008.01.036
   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
NR 7
TC 17
Z9 23
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD MAY
PY 2012
VL 41
IS 5
BP 1069
EP 1071
DI 10.1093/ejcts/ezr196
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 930TA
UT WOS:000303161800032
PM 22219471
OA Bronze
DA 2026-07-24
ER
PT J
AU Orseck, MJ
   Trujillo, MG Jr
   Ritter, EF
AF Orseck, Michael J.
   Trujillo, Manny G., Jr.
   Ritter, Edmond F.
TI Screw Fixation of Dermal Regeneration Template for Scalp Reconstruction
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE dermal regeneration template; Integra; scalp; scalp reconstruction;
   screw fixation; fixation
ID DEFECTS; INTEGRA; SKIN
AB Despite many advances in reconstructive techniques, the full-thickness scalp defect remains a difficult problem for the reconstructive surgeon. Patient and disease-specific factors occasionally make reconstruction with a dermal regeneration template (DRT) an attractive option when other methods are less advised. Although the applicability of dermal regeneration templates has been well elucidated, the method of DRT immobilization has not been standardized. Given the difficulty of adherence and subsequent infiltration of host cells into the DRT from the underlying bone due to seroma, hematoma, or shearing forces, we propose a screw and bolster system for DRT immobilization. We present a series of 13 patients with full-thickness scalp loss who underwent reconstruction with DRT and a subsequent split-thickness skin graft. All 13 patients were treated with the screw-bolster method of DRT fixation before a vacuum-assisted closure dressing. The average surface area of the defect was 96 cm(2). The mean time interval between the application of DRT and skin graft was 28 days. At a mean of 9-month follow-up, all patients achieved a well-vascularized neo-dermis, and progressed to complete, stable wound healing following application of a split-thickness skin graft. We propose that a screw-bolster system of fixation is a safe and effective method of immobilizing DRT in full-thickness scalp defects.
C1 [Trujillo, Manny G., Jr.] Spartanburg Reg Med Ctr, Dept Surg Educ, Spartanburg, SC 29303 USA.
   [Orseck, Michael J.] Spartanburg Reg Med Ctr, Div Plast Surg, Spartanburg, SC 29303 USA.
   [Ritter, Edmond F.] Med Coll Georgia, Div Plast Surg, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University
RP Trujillo, MG Jr (通讯作者)，Spartanburg Reg Med Ctr, Dept Surg Educ, 101 E Wood St, Spartanburg, SC 29303 USA.
EM mtrujillomd@gmail.com
CR [Anonymous], PLAST RECONSTR SURG
   BURKE JF, 1981, ANN SURG, V194, P413, DOI 10.1097/00000658-198110000-00005
   Gonyon DL Jr, 2003, ANN PLAS SURG, V50, P315, DOI 10.1097/01.SAP.0000046788.45508.A3
   Khan MAA, 2010, J CRANIOFAC SURG, V21, P905, DOI 10.1097/SCS.0b013e3181d8418e
   Komorowska-Timek E, 2005, PLAST RECONSTR SURG, V115, P1010, DOI 10.1097/01.PRS.0000154210.60284.C6
   Lee Samson, 2006, Curr Opin Otolaryngol Head Neck Surg, V14, P249, DOI 10.1097/01.moo.0000233595.61305.d8
   Leedy Jason E, 2005, Plast Reconstr Surg, V116, p54e, DOI 10.1097/01.prs.0000179188.25019.6c
NR 7
TC 11
Z9 12
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2012
VL 68
IS 5
BP 457
EP 460
DI 10.1097/SAP.0b013e318243390b
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 930UD
UT WOS:000303166200011
PM 22531400
OA hybrid
DA 2026-07-24
ER
PT J
AU Ross, RE
   Aflaki, P
   Gendics, C
   Lantis, JC
AF Ross, R. E.
   Aflaki, P.
   Gendics, C.
   Lantis, J. C., II
TI Complex lower extremity wounds treated with skin grafts and NPWT: a
   retrospective review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE split-thickness skin grafts; negative wound pressure therapy; lower
   extremity wounds
ID VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE DRESSINGS; FOREARM DONOR
   SITE; LEG ULCERS; BOLSTER; DEVICE; SURVIVAL
AB Objective: To evaluate a single centre experience with the use of NPWT for securing split-thickness skin grafts in the management of specifically lower extremity chronic wounds, including revascularised arterial wounds, amputations, diabetic and venous leg ulcers.
   Method:A seven-year retrospective review of a prospectively maintained database of all the patients who underwent primary split-thickness skin grafts (STSG) with immediate postoperative NPWT for at least 96 hours was carried out. The percentage graft take after removal of NPWT device and clinical follow-up date were reviewed.
   Results: A total of 59 skin grafts procedures had adequate follow up to be reviewed. This included 39% post-debridement/ amputation wounds in patients that presented with diabetic foot infection/ gangrene, 31% venous leg ulcers, and 31% other post-surgical wounds (arterial ulcers that had undergone revascularisation). The mean percentage graft survival after removal of VAC was 94%; 63% of cases had complete graft survival, 25% had 90-99% survival, and 8.5% had 80-89% survival. Outpatient follow up ranged from 2 weeks to 5 years (mean of 10 months). Fifteen per cent of patients were lost to follow up, and of the remaining patients, 76% remained completely healed, 10% remained partially healed, and 14% lost the entire STSG.
   Conclusion: Patients with STSG secured with NPWT required fewer repeated grafting procedures, had very high initial graft survival with complete recipient bed coverage, and had good long term wound closure rates compared with historical controls. While retrospective reviews, such as this, support NPWT as a good method of STSG affixation, the paucity of reviews of other methods does not allow for good historic comparison, so a well enrolled prospective trial would be of use.
C1 [Ross, R. E.; Aflaki, P.; Gendics, C.; Lantis, J. C., II] Columbia Univ, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Div Vasc Endovasc Surg, New York, NY 10027 USA.
C3 Mount Sinai West; Columbia University; Mount Sinai Morningside
RP Ross, RE (通讯作者)，Columbia Univ, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Div Vasc Endovasc Surg, New York, NY 10027 USA.
EM Jcl161@columbia.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Chio EG, 2010, OTOLARYNG HEAD NECK, V142, P174, DOI 10.1016/j.otohns.2009.11.003
   FLOWERS RS, 1970, SURG CLIN N AM, V50, P439
   Hallberg H, 2003, SCAND J PLAST RECONS, V37, P97, DOI 10.1080/02844310310005621
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   Jewell L, 2007, PLAST RECONSTR SURG, V120, P451, DOI 10.1097/01.prs.0000267416.64164.7e
   Körber A, 2008, DERMATOLOGY, V216, P250, DOI 10.1159/000112937
   Lantis J., 2004, 2 WORLD UN WOUND HEA
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Molnar JA, 2000, PLAST RECONSTR SURG, V105, P174, DOI 10.1097/00006534-200001000-00030
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mowlavi A, 2000, ANN PLAS SURG, V45, P629, DOI 10.1097/00000637-200045060-00010
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   Rudolph RB, 1990, PLASTIC SURG
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
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   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
   Weinfeld AB, 2005, ANN PLAS SURG, V54, P178, DOI 10.1097/01.sap.0000143606.39693.3f
   WINTER GD, 1962, NATURE, V193, P293, DOI 10.1038/193293a0
   WOOD MK, 1995, ANN ROY COLL SURG, V77, P222
   Younan G, 2010, PLAST RECONSTR SURG, V126, P87, DOI 10.1097/PRS.0b013e3181da86d0
   Zuhaili B, 2010, PLAST RECONSTR SURG, V125, P855, DOI 10.1097/PRS.0b013e3181ccdc42
NR 30
TC 20
Z9 24
U1 0
U2 19
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2011
VL 20
IS 10
BP 490
EP +
DI 10.12968/jowc.2011.20.10.490
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 931BR
UT WOS:000303189700007
PM 22067888
DA 2026-07-24
ER
PT J
AU Moffatt, CJ
   Mapplebeck, L
   Murray, S
   Morgan, PA
AF Moffatt, C. J.
   Mapplebeck, L.
   Murray, S.
   Morgan, P. A.
TI The experience of patients with complex wounds and the use of NPWT in a
   home-care setting
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE developing a wound through crisis; living with a complex wound; NPWT;
   recommendations for care
ID SELF-MANAGEMENT; SOCIAL SUPPORT; ADHERENCE; METAANALYSIS; ULCER; PAIN
AB Objective: To explore the experience of patients living with complex wounds and the impact of undergoing negative pressure wound therapy (NPWT) as part of their treatment.
   Method: Qualitative data were collected from eight patients, using semi-structured interviews. A purposive, stratified sampling approach was used to identify participants with a range of wound types, as well as age and gender. Participants were recruited from one primary care trust and were interviewed, following 10 days of treatment with NPWT. The matrix-based 'Framework' approach, from the National Centre for Social Research, was used to structure the analysis.
   Results:Of the eight participants recruited, five were female and three male,with an age range of 46-77 years. Five overarching categories, with their constituent themes, were identified from the data. The first, developing a wound through crisis, has three themes:a failing body, missed diagnosis and failed professional intervention. The second category, decreased control, has four related themes: poor communication;failed wound healing; poor discharge planning and failure to recover. The third category, increased control, has four themes: understanding what is happening; symptom control; positive professional relationships and returning to health. The fourth category, using NPWT, has two themes: information and understanding of NPWT and expectations and experience of NPWT. The final category sets out participant recommendations about the device and has two themes: device issues and improving professional practice.
   Conclusion: This study investigated the experience of patients undergoing NPWT for complex wounds in the home setting and reveals a number of the psychosocial effects of using this therapy in this environment. Participants saw NPWT as an active intervention, associated with improved wound healing and symptom control. The participant experience described in this study, and the recommendations they make, provide a valuable resource to inform service improvement programmes and wound research.
   Declaration of interest: This study was supported by a research grant from Smith & Nephew Ltd.
C1 [Moffatt, C. J.; Murray, S.; Morgan, P. A.] Derby Hosp NHS Fdn Trust, Lymphoedema Serv, Royal Derby Hosp, Derby, England.
   [Moffatt, C. J.] Univ Nottingham, Sch Nursing Midwifery & Physiotherapy, Queens Med Ctr, Nottingham NG7 2RD, England.
   [Mapplebeck, L.] N E Lincolnshire Care Plus Trust, Lincoln, England.
C3 University of Nottingham; University of Nottingham
RP Moffatt, CJ (通讯作者)，Derby Hosp NHS Fdn Trust, Lymphoedema Serv, Royal Derby Hosp, Derby, England.
EM philip.morgan5@nhs.net
OI Moffatt, Christine/0000-0002-2436-0129
FU Smith Nephew Ltd.
FX This study was supported by a research grant from Smith & Nephew Ltd.
CR [Anonymous], 2009, BMJ
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NR 26
TC 24
Z9 31
U1 0
U2 10
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2011
VL 20
IS 11
BP 512
EP +
DI 10.12968/jowc.2011.20.11.512
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA 931BS
UT WOS:000303189800004
PM 22240846
DA 2026-07-24
ER
PT J
AU Valiente, LH
   García-Alcalá, DG
   Paz, PS
   Rowan, S
AF Herrero Valiente, L.
   Garcia-Alcala, D. G.
   Serrano Paz, P.
   Rowan, S.
TI The challenges of managing a complex stoma with NPWT
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE colostomy; stoma; wound; negative pressure wound therapy
ID PRESSURE-WOUND-THERAPY; VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE;
   POLYURETHANE-FOAM; GAUZE; WALL
AB This paper reports the clinical experience of a 71-year-old female with resection of the colon, who subsequently developed postoperative complications. A colostomy was carried out; necrosis of the colostomy edges and stoma retraction complicated optimal stoma appliance placement. It was possible to treat the resulting cavity with negative pressure wound therapy (NPWT) by isolating the stoma and treating the peristomal wound area. The wound was treated with NPWT for 30 days; at day 20, the patient was discharged to home to continue with NPWT for a further 10 days by community nurses, with regular follow-up visits in the outpatient clinic. The patient improved steadily and achieved complete closure of the wound.
C1 [Herrero Valiente, L.] Hosp Elche, Gen & Vasc Surg Dept, Elche, Spain.
   [Serrano Paz, P.] Hosp Elche, Dept Gen Surg, Coloproctol Unit, Elche, Spain.
RP Valiente, LH (通讯作者)，Hosp Elche, Gen & Vasc Surg Dept, Elche, Spain.
EM herrero_luival@gva.es
CR Byrnes MC, 2010, SURG INFECT, V11, P505, DOI 10.1089/sur.2010.032
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   Malmsjo M, 2010, WOUNDS INT, V1, P1
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NR 19
TC 3
Z9 4
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2012
VL 21
IS 3
BP 120
EP 123
DI 10.12968/jowc.2012.21.3.120
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 932GR
UT WOS:000303278900003
PM 22399079
DA 2026-07-24
ER
PT J
AU Khanbhai, M
   Fosah, R
   Oddy, MJ
   Richards, T
AF Khanbhai, M.
   Fosah, R.
   Oddy, M. J.
   Richards, T.
TI Disposable NPWT device to facilitate early patient discharge following
   complex DFU
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE diabetic foot; negative pressure wound therapy
ID FOOT ULCERS; THERAPY; COST
AB Negative pressure wound therapy (NPWT) is a valuable tool in complex wound management. Despite its popularity, NPWT therapy systems can have drawbacks, including reduced mobility and cost; therefore, NPWT is predominantly hospital based. The advent of a new, lightweight and disposable system may aid early discharge and permit outpatient treatment. This case report describes how one such system facilitated early discharge in a patient with a complex diabetic foot ulcer
C1 [Khanbhai, M.] UCL, London WC1E 6BT, England.
   [Fosah, R.; Oddy, M. J.; Richards, T.] Univ Coll London Hosp, London, England.
C3 University of London; University College London; University of London;
   University College London; University College London Hospitals NHS
   Foundation Trust
RP Khanbhai, M (通讯作者)，UCL, London WC1E 6BT, England.
EM mustafa.khanbhai@doctors.org.uk
RI Richards, Toby/K-6547-2013
OI Richards, Toby/0000-0001-9872-4653
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   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Barringer CB, 2004, BRIT J PLAST SURG, V57, P482, DOI 10.1016/j.bjps.2004.01.005
   Kilpadi D, 2006, WOUND REPAIR REGEN, V14, P210, DOI 10.1111/j.1743-6109.2006.00112.x
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NR 12
TC 7
Z9 8
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2012
VL 21
IS 4
BP 180
EP +
DI 10.12968/jowc.2012.21.4.180
PG 2
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 932GS
UT WOS:000303279000005
PM 22584676
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Malmsjö, M
   Hansson, J
   Hlebowicz, J
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Hansson, Johan
   Hlebowicz, Joanna
   Ingemansson, Richard
TI Pressure transduction and fluid evacuation during conventional negative
   pressure wound therapy of the open abdomen and NPWT using a protective
   disc over the intestines
SO BMC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; PACK TECHNIQUE;
   7-YEAR EXPERIENCE; TEMPORARY CLOSURE; LAPAROSTOMY; FISTULAS; SEPSIS;
   WALL
AB Background: Negative pressure wound therapy (NPWT) has gained acceptance among surgeons, for the treatment of open abdomen, since very high closure rates have been reported with this method, compared to other kinds of wound management for the open abdomen. However, the method has occasionally been associated with increased development of fistulae. We have previously shown that NPWT induces ischemia in the underlying small intestines close to the vacuum source, and that a protective disc placed between the intestines and the vacuum source prevents the induction of ischemia. In this study we compare pressure transduction and fluid evacuation of the open abdomen with conventional NPWT and NPWT with a protective disc.
   Methods: Six pigs underwent midline incision and the application of conventional NPWT and NPWT with a protective disc between the intestines and the vacuum source. The pressure transduction was measured centrally beneath the dressing, and at the anterior abdominal wall, before and after the application of topical negative pressures of -50, -70 and -120 mmHg. The drainage of fluid from the abdomen was measured, with and without the protective disc.
   Results: Abdominal drainage was significantly better (p < 0. 001) using NPWT with the protective disc at -120 mmHg (439 +/- 25 ml vs. 239 +/- 31 ml), at -70 mmHg (341 +/- 27 ml vs. 166 +/- 9 ml) and at -50 mmHg (350 +/- 50 ml vs. 151 +/- 21 ml) than with conventional NPWT. The pressure transduction was more even at all pressure levels using NPWT with the protective disc than with conventional NPWT.
   Conclusions: The drainage of the open abdomen was significantly more effective when using NWPT with the protective disc than with conventional NWPT. This is believed to be due to the more even and effective pressure transduction in the open abdomen using a protective disc in combination with NPWT.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
   [Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, SE-22185 Lund, Sweden.
   [Hansson, Johan] Uppsala Univ, Fac Med, Inst Surg Sci, Uppsala, Sweden.
   [Hlebowicz, Joanna] Malmo Univ Hosp, Dept Med, Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Uppsala University; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Ingemansson,
   Richard/0000-0001-7623-8953; Maljö, Malin/0000-0001-9849-9599
CR Amin AI, 2009, WORLD J GASTROENTERO, V15, P3394, DOI 10.3748/wjg.15.3394
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NR 26
TC 15
Z9 17
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD MAR 24
PY 2012
VL 12
AR 4
DI 10.1186/1471-2482-12-4
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 933DC
UT WOS:000303338600001
PM 22443416
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Argenta, LC
   Zheng, ZL
   Bryant, A
   Tatter, SB
   Morykwas, MJ
AF Argenta, Louis C.
   Zheng, Zhenlin
   Bryant, Allyson
   Tatter, Stephen B.
   Morykwas, Michael J.
TI A New Method for Modulating Traumatic Brain Injury With Mechanical
   Tissue Resuscitation
SO NEUROSURGERY
LA English
DT Article
DE Subatmospheric pressure treatment; Tissue resuscitation; Traumatic brain
   injury
ID CONTROLLED CORTICAL IMPACT; MAGNETIC-RESONANCE-SPECTROSCOPY;
   VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; COMPARTMENT SYNDROME;
   COGNITIVE DEFICITS; MR SPECTROSCOPY; CEREBRAL EDEMA; WOUND FLUID; RAT
   MODELS
AB BACKGROUND: Traumatic brain injuries remain a treatment enigma with devastating late results. As terminally differentiated tissue, the brain retains little capacity to regenerate, making early attempts to preserve brain cells after brain injury essential.
   OBJECTIVE: To resuscitate damaged tissue by modulating edema, soluble cytokines, and metabolic products in the "halo" of damaged tissue around the area of central injury that progressively becomes compromised. By re-equilibrating the zone of injury milieu, it is postulated neurons in this area will survive and function.
   METHODS: Mechanical tissue resuscitation used localized, controlled, subatmospheric pressure directly to the area of controlled cortical impact injury and was compared with untreated injured controls and with sham surgery in a rat model. Functional outcome, T2 magnetic resonance imaging hyperintense volume, magnetic resonance imaging spectroscopy metabolite measurement, tissue water content, injury cavity area, and cortical volume were compared.
   RESULTS: There were significant differences between mechanical tissue resuscitation treated and untreated groups in levels of myoinositol, N-acetylaspartate, and creatine. Treated animals had significantly less tissue swelling and density than the untreated animals. Nonviable brain tissue areas were smaller in treated animals than in untreated animals. Treated animals performed better than untreated animals in functional tests. Histological analysis showed the remaining viable ipsilateral cerebral area was 58% greater for treated animals than for untreated animals, and the cavity for treated animals was 95% smaller than for untreated animals 1 month after injury.
   CONCLUSION: Mechanical tissue resuscitation with controlled subatmospheric pressure can significantly modulate levels of excitatory amino acids and lactate in traumatic brain injury, decrease the water content and volume of injured brain, improve neuronal survival, and speed functional recovery.
C1 [Argenta, Louis C.; Zheng, Zhenlin; Bryant, Allyson; Morykwas, Michael J.] Wake Forest Univ Hlth Sci, Dept Plast & Reconstruct Surg, Winston Salem, NC USA.
   [Tatter, Stephen B.] Wake Forest Univ Hlth Sci, Dept Neurosurg, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest University School of Medicine; Wake
   Forest University; Wake Forest University School of Medicine
RP Argenta, LC (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM largenta@wfubmc.edu
RI ; Tatter, Stephen/AAD-6524-2021
OI Morykwas, Michael/0009-0001-5547-5172; Tatter,
   Stephen/0000-0002-1063-0431
FU Wake Forest University Department of Plastic and Reconstructive Surgery;
   REPAIRx Laboratories of the Department of Plastic and Reconstructive
   Surgery
FX This study was supported in part by funds from the Cheek Endowment of
   Wake Forest University Department of Plastic and Reconstructive Surgery.
   Support was also obtained from REPAIRx Laboratories of the Department of
   Plastic and Reconstructive Surgery. Wake Forest Health Sciences has
   applied for patents related to this material. No licenses or royalties
   have been granted. The authors have no personal financial or
   institutional interest in any of the drugs, materials, or devices
   described in this article.
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NR 79
TC 11
Z9 13
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-396X
EI 1524-4040
J9 NEUROSURGERY
JI Neurosurgery
PD MAY
PY 2012
VL 70
IS 5
BP 1281
EP 1295
DI 10.1227/NEU.0b013e3182446760
PG 15
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 933VA
UT WOS:000303390400060
PM 22157550
DA 2026-07-24
ER
PT J
AU Armstrong, DG
   Marston, WA
   Reyzelman, AM
   Kirsner, RS
AF Armstrong, David G.
   Marston, William A.
   Reyzelman, Alexander M.
   Kirsner, Robert S.
TI Comparative effectiveness of mechanically and electrically powered
   negative pressure wound therapy devices: A multicenter randomized
   controlled trial
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; GAUZE; CARE;
   TRANSDUCTION; SYSTEM; STATE; FOAM
AB This study was designed to compare the ultraportable mechanically powered Smart Negative Pressure (SNaP) Wound Care System (Spiracur, Sunnyvale, CA) with the electrically powered Vacuum-Assisted Closure (VAC) Therapy System (Kinetic Concepts, Inc. [KCI], San Antonio, TX) in a multicenter, comparative efficacy, noninferiority-powered, randomized controlled trial. We enrolled 132 people with noninfected, nonischemic, nonplantar lower extremity diabetic and venous wounds. Each subject was randomly assigned (1:1) to treatment with either system in conjunction with appropriate off-loading and compression therapy. The trial evaluated treatment for up to 16 weeks or complete wound closure (defined as complete reepithelialization without drainage). Primary end point analysis of wound size reduction found that SNaP-treated subjects demonstrated noninferiority to the VAC-treated subjects at 4, 8, 12, and 16 weeks (p?=?0.0030, 0.0130, 0.0051, and 0.0044, respectively). KaplanMeier analysis showed no significant difference in complete wound closure between SNaP- and VAC-treated subjects at all time points. Device related adverse events and complications such as infection were also similar between treatment groups. These data support similar wound healing outcomes between the SNaP system and the VAC system in the population studied.
C1 [Armstrong, David G.] Univ Arizona, Coll Med, So Arizona Limb Salvage Alliance SALSA, Tucson, AZ 85724 USA.
   [Marston, William A.] Univ N Carolina, Sch Med, Dept Surg, Div Vasc Surg, Chapel Hill, NC USA.
   [Reyzelman, Alexander M.] Samuel Merritt Univ, Dept Med, Calif Sch Podiatr Med, Oakland, CA USA.
   [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
C3 University of Arizona; University of North Carolina; University of North
   Carolina Chapel Hill; University of North Carolina School of Medicine;
   Samuel Merritt University; University of Miami
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, So Arizona Limb Salvage Alliance SALSA, 1501 N Campbell Ave,POB 245072, Tucson, AZ 85724 USA.
EM armstrong@usa.net
FU Spiracur, Inc.; KCI
FX This study was sponsored by a grant from Spiracur, Inc. Two authors (DGA
   and WAM) have received research funding from both Spiracur, Inc. and
   KCI.
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NR 27
TC 54
Z9 63
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2012
VL 20
IS 3
BP 332
EP 341
DI 10.1111/j.1524-475X.2012.00780.x
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 936NY
UT WOS:000303598500008
PM 22564228
DA 2026-07-24
ER
PT J
AU Rahmanian-Schwarz, A
   Willkomm, LM
   Ganser, P
   Hirt, B
   Schaller, HE
AF Rahmanian-Schwarz, Afshin
   Willkomm, Lina-Marie
   Ganser, Philipp
   Hirt, Bernhard
   Schaller, Hans-Eberhard
TI A novel option in negative pressure wound therapy (NPWT) for chronic and
   acute wound care
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy; RENASYS GO; VAC; Foam-based NPWT
   system; Wound dressing; Acute and chronic wounds
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; CLINICAL-EFFICACY;
   MANAGEMENT; TRIAL; STATE
AB Introduction: Negative pressure wound therapy (NPWT) has become a widely accepted technique in treatment of all kinds of wounds. After a long period of clinical application of the V.A.C.(TM) system (KCI Inc., San Antonio, Texas, USA) a number of options for delivery of NPWT are now commercially available. An urgent need exists for evidence demonstrating clinical efficacy of these new devices to support clinicians regarding their choice of NPWT.
   Methods: 42 patients with an acute or chronic wound were randomly assigned to either treatment by V.A.C.(TM) (group A) or therapy with an alternative newly available polyurethane foam-based NPWT system (RENASYS GO (TM) - F/P, Smith & Nephew GmbH) (group B). In both groups NPWT was applied after surgical debridement to prepare the wound bed for skin grafting. After skin grafting NPWT was applied additionally to secure skin grafts and improve grafts survival. Primary outcome measures were the time to complete healing (days) and duration of the NPWT application (days). Secondary outcome measures were the number of dressing changes and reported complications. In addition, we evaluated the cost-benefit in the clinical implementation.
   Results: There were no significant differences comparing the investigated parameters between both groups. Especially average time to complete healing and average time NPWT was applied did not differ (p > 0.05). No complications occurred in either group. By an almost identical supply agreement of both providers for our hospital RENASYS (TM) system appeared to be more cost-effective.
   Conclusion: After a long period of preserving a monopoly market position of the V.A.C.(TM) system, a new comparable option was successfully tested in this preliminary study. The polyurethane foam-based NPWT system (RENASYS GO (TM) - F/P, Smith & Nephew GmbH) is an efficient and cost-effective alternative NPWT system, which we effectively implemented in therapeutic management of different kinds of wounds. (C) 2011 Elsevier Ltd and ISBI. All rights reserved.
C1 [Rahmanian-Schwarz, Afshin; Willkomm, Lina-Marie; Ganser, Philipp; Schaller, Hans-Eberhard] Univ Tubingen, BG Trauma Ctr, Dept Plast Reconstruct Hand & Burn Surg, D-72074 Tubingen, Germany.
   [Hirt, Bernhard] Univ Tubingen, Dept Anat, D-72074 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University of
   Tubingen
RP Rahmanian-Schwarz, A (通讯作者)，Univ Tubingen, BG Trauma Ctr, Dept Plast Reconstruct Hand & Burn Surg, D-72074 Tubingen, Germany.
EM arahmanian@bgu-tuebingen.de
CR [Anonymous], GER MED SCI
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NR 28
TC 41
Z9 45
U1 0
U2 22
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD JUN
PY 2012
VL 38
IS 4
BP 573
EP 577
DI 10.1016/j.burns.2011.10.010
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 937VQ
UT WOS:000303691500016
PM 22100423
DA 2026-07-24
ER
PT J
AU Albert, NM
   Rock, R
   Sammon, MA
   Bena, JF
   Morrison, SL
   Whitman, A
   Kato, I
   Landis-Erdman, JC
AF Albert, Nancy M.
   Rock, Ronald
   Sammon, Mary Ann
   Bena, James F.
   Morrison, Shannon L.
   Whitman, Angela
   Kato, Irene
   Landis-Erdman, Judith C.
TI Do Patient and Nurse Outcome Differences Exist Between 2 Negative
   Pressure Wound Therapy Systems?
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; MANAGEMENT; ULCERS; COST
AB PURPOSE: We prospectively compared the effectiveness of foam- and gauze-based negative pressure wound therapy (NPWT) systems on wound healing, pain, cost, and hospital length of stay. We also compare ease of use and time in performing dressing changes reported by nurses.
   DESIGN: Randomized, controlled clinical trial comparing foam- and gauze-based NPWT systems.
   SUBJECTS AND SETTING: Eleven adult subjects with physician orders for NPWT participated in the study. Subjects were middle-aged, white, and male.
   METHODS: Six subjects were randomly allocated to foam- based and 5 to gauze-based NPWT systems. Wound healing rates and pain at the first dressing change were measured using a centimeter ruler and a visual analog scale, respectively. Wound care costs were tabulated from a checklist of supplies used and nurse perceptions were measured by responses to Likert-type surveys. Relationships between NPWT system and selected variables were measured using Wilcoxon rank sum tests.
   RESULTS: Median wound healing rates did not differ significantly between foam- based and gauze-based NPWT systems when measured in centimeters at first dressing change for length (10.6 vs 16.5, P = .58), width (2.7 vs 4.2, P = .41), depth (2.2 vs 2.5, P = .78), and tunneling and undermining (both 0 vs 0, P = .82 and.79, respectively). No differences were detected in pain rating at first dressing change (3.2 vs 2.4, P = .77), cost of wound care ($510.18 vs $333.54 P = .86), or hospital length of stay (26.33 vs 14.8 days; P = .58), respectively. There were no differences in nurses' experiences in ease of performing dressing changes and mean time to perform the first dressing change for foam- or gauze-based NPWT systems: 32.3 vs 38.8 minutes; P = .52, respectively.
   CONCLUSIONS: In a pilot study comparing the effectiveness of foam- and gauze-based NPWT systems, no statistically significant differences were found in patient wound healing, pain, length of stay, or cost of wound care. Nursing time and perceptions about the ease of preparing and completing dressing changes did not differ between systems. Additional research is needed to more definitively determine any differences in wound healing or nurse satisfaction using gauze-versus foam-based NPWT systems.
C1 [Albert, Nancy M.] Cleveland Clin, Nursing Inst, Cleveland, OH 44195 USA.
   [Sammon, Mary Ann; Landis-Erdman, Judith C.] Cleveland Clin, Wound Care Consult Team, Cleveland, OH 44195 USA.
   [Whitman, Angela] Cleveland Clin, Vasc Surg Stepdown Unit, Cleveland, OH 44195 USA.
   [Kato, Irene] Cleveland Clin, Colo Rectal Surg Unit, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Cleveland
   Clinic Foundation; Cleveland Clinic Foundation
RP Albert, NM (通讯作者)，Cleveland Clin, Nursing Inst, 9500 Euclid Ave,Mail Code J3-4, Cleveland, OH 44195 USA.
EM albertn@ccf.org
RI Albert, Nancy/ACQ-4895-2022
FU Smith & Nephew (St. Petersburg, Florida)
FX We thank Cheryl Patterson, PhD, MBA, RN, and Patricia Adler, PhD, RN,
   for their roles in study oversight and Laura Rinker, RN, CPN, for her
   role in coordination of patient enrollment. Smith & Nephew (St.
   Petersburg, Florida) provided partial funding for data collection and
   full funding of statistical analysis.
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NR 30
TC 14
Z9 14
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2012
VL 39
IS 3
BP 259
EP 266
DI 10.1097/WON.0b013e3182487a50
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 940VJ
UT WOS:000303920900006
PM 22552107
DA 2026-07-24
ER
PT J
AU Buote, NJ
   Havig, ME
AF Buote, Nicole J.
   Havig, Marc E.
TI The Use of Vacuum-Assisted Closure in the Management of Septic
   Peritonitis in Six Dogs
SO JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION
LA English
DT Article
ID GENERALIZED PERITONITIS; ABDOMINAL DRAINAGE; CATS; INFECTIONS; THERAPY;
   LACTATE
AB The purpose of this study was to describe the appropriate surgical technique, postoperative monitoring, and complications encountered with use of vacuum-assisted closure (VAC) in six dogs with confirmed septic peritonitis. Initial diagnosis of septic peritonitis was performed by measuring either the blood-to-fluid lactate ratio and glucose concentration differences or cytologic verification of intracellular bacteria. After appropriate surgical procedures were performed to manage the primary cause of peritoneal sepsis, a VAC was performed. Serum and abdominal fluid protein levels were measured, and all complications were noted during the postoperative period. Three of the six dogs (50%) survived to the secondary closure and were subsequent discharged, which is similar to previous studies where the abdomen was either closed primarily or treated with open abdominal drainage. No major complications occurred with bandage management during hospitalization. The results of this study support VAC as a feasible technique for managing septic peritonitis. (J Am Anim Hosp Assoc 2012; 48:164-171. DOI 10.5326/JAAHA-MS-5755)
C1 [Buote, Nicole J.; Havig, Marc E.] Anim Med Ctr, Dept Surg, New York, NY 10021 USA.
RP Buote, NJ (通讯作者)，Vet Ctr Amer W Lost Angeles, Los Angeles, CA 90025 USA.
EM njbuote@aol.com
RI Buote, Nicole/HKF-2946-2023
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NR 29
TC 20
Z9 20
U1 0
U2 16
PU AMER ANIMAL HOSPITAL ASSOC
PI LAKEWOOD
PA PO BOX 150899, LAKEWOOD, CO 80215-0899 USA
SN 0587-2871
EI 1547-3317
J9 J AM ANIM HOSP ASSOC
JI J. Am. Anim. Hosp. Assoc.
PD MAY-JUN
PY 2012
VL 48
IS 3
BP 164
EP 171
DI 10.5326/JAAHA-MS-5755
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 940XO
UT WOS:000303926600002
PM 22474052
DA 2026-07-24
ER
PT J
AU Li, W
   Meng, QG
   Bi, ZG
AF Li, W.
   Meng, Q. -G.
   Bi, Z. -G.
TI Clinical results of vacuum sealing drainage combined with sural nerve
   flap for soft tissue defect
SO MINERVA ORTOPEDICA E TRAUMATOLOGICA
LA English
DT Article
DE Sural nerve; Drainage; Soft tissue infections
ID ASSISTED CLOSURE; COVERAGE
AB Aim. The sural nerve flap failure is still a problem for the patient with reconstructive surgery. The cause were attributed to infection, tension and insufficient debridement. Negative pressure when applied to soft tissue defects results in a significant increase ingranulation tissue production compared to similar conventionally treated wounds in the patients. There were no clinical signs of infection and cultures were negtive in any of the wounds that achieved complete closure.
   Methods. We used vacuum sealing drainage (VSD) combined with sural nerve flap for the reconstruction of defects of lower one-third of the leg, foot and ankel.with exposed tendon or bone in 25 patients between 2007 and 2009. The defects were covered with no major complications.
   Results. All 25 flaps survived after the operation. The blood supply and venous return of the skin flaps were good. In 2 flaps, there was a small amount of distal marginal necrosis, which was excised and closed spontaneously or skin grafted. Slight venous congestion of the flap occurred in one patients, which were cured by removing some sutures. No other clinical abnormalities were discovered. Mean follow-up was 17 months (5-24 months). The flap was warm, and no venous congestion was observed.
   Conclusion. We concluded that the vacuum sealing drainage combined with sural nerve flap can be recommended for the treatment of acute traumatic soft tissue defects and for soft tissue defects complicated by exposed bone and /or implants.
C1 [Li, W.; Meng, Q. -G.; Bi, Z. -G.] Harbin Med Univ, Dept Orthoped Surg, Affiliated Hosp 4, Harbin, Heilongjiang Pr, Peoples R China.
C3 Harbin Medical University
RP Bi, ZG (通讯作者)，Harbin Med Univ, Affiliated Hosp 1, Dept Orthoped Surg, Harbin, Peoples R China.
EM jbjsbr@126.com
RI bi, zheng/PUC-9915-2026
CR [Anonymous], 2009, ANN PLAST SURG, V63, P77
   Chen SL, 2002, PLAST RECONSTR SURG, V110, P1664, DOI 10.1097/00006534-200212000-00007
   Dersch T, 1994, 4 ANN M WOUND HEAL S
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   Hollier L, 2002, PLAST RECONSTR SURG, V110, P1673, DOI 10.1097/00006534-200212000-00008
   Maffi TR, 2005, ANN PLAS SURG, V54, P302, DOI 10.1097/01.sap.0000146682.75075.b2
   MASQUELET AC, 1992, PLAST RECONSTR SURG, V89, P1115, DOI 10.1097/00006534-199206000-00018
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Savk Ö, 2006, J DERMATOL, V33, P700, DOI 10.1111/j.1346-8138.2006.00162.x
   Yao SQ, MODIFIED
NR 12
TC 0
Z9 0
U1 0
U2 3
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4911
J9 MINERVA ORTOP TRAUMA
JI Minerva Ortop. Traumatol.
PD JUN
PY 2012
VL 63
IS 3
BP 185
EP 191
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 941KM
UT WOS:000303962100007
DA 2026-07-24
ER
PT J
AU Liu, DSH
   Sofiadellis, F
   Ashton, M
   MacGill, K
   Webb, A
AF Liu, David Shi Hao
   Sofiadellis, Foti
   Ashton, Mark
   MacGill, Kirstie
   Webb, Angela
TI Early soft tissue coverage and negative pressure wound therapy optimises
   patient outcomes in lower limb trauma
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Flap; Reconstruction; Trauma; Time; Negative Pressure Wound Therapy;
   Lower Limb
ID SEVERE OPEN FRACTURES; VACUUM-ASSISTED CLOSURE; TIBIAL SHAFT;
   RECONSTRUCTION; FLAP; MANAGEMENT; EXPERIENCE
AB Background: The timing of soft tissue reconstruction for severe open lower limb trauma is critical to its successful outcome, particularly in the setting of exposed metalware and pre-existing wound infection. The use of negative pressure wound therapy (NPWT) may allow a delay in soft tissue coverage without adverse effects. This study evaluated the impact of delayed free-flap reconstruction, prolonged metalware exposure, pre-flap wound infection, and the efficacy of NPWT on the success of soft tissue coverage after open lower limb injury.
   Methods: Retrospective review of all free-flap reconstructions for lower limb trauma undertaken at a tertiary trauma centre between June 2002 and July 2009.
   Results: 103 patients underwent 105 free-flap reconstructions. Compared with patients who were reconstructed within 3 days of injury, the cohort with delayed reconstruction beyond 7 days had significantly increased rates of pre-flap wound infection, flap re-operation, deep metal infection and osteomyelitis. Pre-flap wound infection independently predicted adverse surgical outcomes. In the setting of exposed metalware, free-flap transfer beyond one day significantly increased the flap failure rate. These patients required more surgical procedures and a longer hospital stay. The use of NPWT significantly lowered the rate of flap re-operations and venous thrombosis, but did not allow a delay in reconstruction beyond 7 days from injury without a concomitant rise in skeletal and flap complications.
   Conclusions: Following open lower limb trauma, soft tissue coverage within 3 days of injury and immediately following fracture fixation with exposed metalware minimises pre-flap wound infection and optimises surgical outcomes. NPWT provides effective temporary wound coverage, but does not allow a delay in definitive free-flap reconstruction. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Liu, David Shi Hao; Sofiadellis, Foti; Ashton, Mark; MacGill, Kirstie; Webb, Angela] Royal Melbourne Hosp, Dept Plast & Reconstruct Surg, Parkville, Vic 3050, Australia.
C3 Melbourne Health; Royal Melbourne Hospital
RP Liu, DSH (通讯作者)，Royal Melbourne Hosp, Dept Plast & Reconstruct Surg, Level 7,Grattan St, Parkville, Vic 3050, Australia.
EM dshliu@bigpond.com; fsofia@gmail.com; mwashton@iimetro.com.au;
   kmacgill@optusnet.com.au; dr.a.webb@gmail.com
OI Webb, Angela/0000-0002-0659-8029
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NR 25
TC 92
Z9 112
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JUN
PY 2012
VL 43
IS 6
BP 772
EP 778
DI 10.1016/j.injury.2011.09.003
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 942LI
UT WOS:000304045100016
PM 22001504
DA 2026-07-24
ER
PT J
AU Li, RG
   Yu, B
   Wang, G
   Chen, B
   Qin, CH
   Guo, G
   Jin, D
   Ren, GH
AF Li, Run-Guang
   Yu, Bin
   Wang, Gang
   Chen, Bin
   Qin, Cheng-He
   Guo, Gang
   Jin, Dan
   Ren, Gao-Hong
TI Sequential therapy of vacuum sealing drainage and free-flap
   transplantation for children with extensive soft-tissue defects below
   the knee in the extremities
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Free flap; Transplantation; Vacuum sealing drainage (VSD) technique;
   Microsurgical technique
ID PRESSURE WOUND THERAPY; CROSS-LEG FLAP; ASSISTED CLOSURE;
   RECONSTRUCTION; TRAUMA; INJURIES; FOOT
AB Purpose: The aim of the study is to evaluate the surgical technique and clinical significance of the sequential therapy of vacuum sealing drainage (VSD) and free-flap transplantation for children with extensive soft-tissue defects below the knee in the extremities.
   Methods: Twenty-two children (aged from 3 to 10 years) received sequential therapy of VSD and free-flap transplantation. All cases suffered from extensive area soft-tissue defects and exposure or partial defects of bones, tendons and other deep tissues. The wound sizes varied from 10 cm x 6 cm to 30 cm x 22 cm. Amongst 22 cases, 12 cases had fresh wounds and the remaining 10 children had necrotising infection. After complete debridement, the wounds were covered by VSD. External fixation or Kirschner-wire fixation should be performed for the cases complicated by unsteady fractures. After the removal of negative pressure VSD devices, free-flap transplantations were performed in 8 cases after debridement, and 14 cases received combined therapy of free-flap transplantation and skin grafting depending upon the severity of soft-tissue and deep-tissue defects. The flap survival and wound healing were followed up postoperatively.
   Results: After VSD treatment, the infection of deep-tissue exposure was effectively prevented, and granulation tissues surrounding the exposed areas of tendons and bones grew well. All patients who received free-flap transplantation at the second stage survived without the occurrence of vascular crisis, infection or sinus formation. During follow-up ranging from 6 to 24 months, all the patients were satisfied with the morphological appearance and functional recovery of the affected limbs.
   Conclusion: Sequential therapy of VSD and free-flap transplantation can serve as a reliable option for children with extensive soft-tissue defects below the knee in the extremities and exposed deep tissues, after complete debridement, which significantly shortens remedy period, enhances success rate for surgery and achieves maximal restoration of limb function. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Li, Run-Guang; Yu, Bin; Wang, Gang; Chen, Bin; Qin, Cheng-He; Guo, Gang; Jin, Dan; Ren, Gao-Hong] So Med Univ, Dept Orthopaed & Traumatol, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China.
C3 Southern Medical University - China
RP Ren, GH (通讯作者)，So Med Univ, Dept Orthopaed & Traumatol, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China.
EM doctor020@163.com
OI Gaohong, Ren/0000-0002-4941-6723; Runguang, Li/0000-0002-4703-7180
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NR 30
TC 36
Z9 65
U1 0
U2 22
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JUN
PY 2012
VL 43
IS 6
BP 822
EP 828
DI 10.1016/j.injury.2011.09.031
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 942LI
UT WOS:000304045100025
PM 22071284
DA 2026-07-24
ER
PT J
AU Dini, M
   Quercioli, F
   Mori, A
   Romano, GF
   Lee, AQ
   Agostini, T
AF Dini, Mario
   Quercioli, Fabio
   Mori, Andrea
   Romano, Gianmaria Federico
   Lee, Alessandro Quattrini
   Agostini, Tommaso
TI Vacuum-assisted closure, dermal regeneration template and degloved
   cryopreserved skin as useful tools in subtotal degloving of the lower
   limb
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Extensive degloving; Cryopreserved skin; Lower limb; Vacuum-assisted
   closure; Dermal regeneration template
ID MANAGEMENT; INJURIES
AB The standard management of degloving injuries involves either immediate grafting with the avulsed skin or full-or split-thickness grafts at a later date. Alternative methods include pedicle and free flaps and revascularisation. The authors present an innovative technique of treating degloving injuries with cryopreserved split-thickness skin grafts harvested from degloved flap, artificial dermal replacement and vacuum-assisted closure (VAC therapy). To the authors' knowledge, this is the first reported case of such bilaminar reconstruction of a degloving injury. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Dini, Mario; Quercioli, Fabio; Mori, Andrea; Romano, Gianmaria Federico; Lee, Alessandro Quattrini; Agostini, Tommaso] Univ Florence, Dept Plast & Reconstruct Surg, I-50100 Florence, Italy.
C3 University of Florence
RP Agostini, T (通讯作者)，Univ Florence, Dept Plast & Reconstruct Surg, Largo Palagi 1, I-50100 Florence, Italy.
EM tommasoagostini@ymail.com
RI Agostini, Tommaso/G-5688-2011
OI Agostini, Tommaso/0000-0001-6743-5218
CR Arnez ZM, J PLAST RECONSTR JAN
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   HIDALGO DA, 1986, CLIN PLAST SURG, V13, P701
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NR 6
TC 25
Z9 34
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JUN
PY 2012
VL 43
IS 6
BP 957
EP 959
DI 10.1016/j.injury.2011.03.020
PG 3
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 942LI
UT WOS:000304045100051
PM 21492856
DA 2026-07-24
ER
PT J
AU Masden, D
   Goldstein, J
   Endara, M
   Xu, K
   Steinberg, J
   Attinger, C
AF Masden, Derek
   Goldstein, Jesse
   Endara, Mathew
   Xu, Kyle
   Steinberg, John
   Attinger, Christopher
TI Negative Pressure Wound Therapy for At-Risk Surgical Closures in
   Patients With Multiple Comorbidities A Prospective Randomized
   Controlled Study
SO ANNALS OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; MESH GRAFTS; SKIN-GRAFTS;
   MULTICENTER; AMPUTATION; INCISIONS; IMPROVES
AB Purpose: The purpose of this study is to evaluate the effect of Negative Pressure Wound Therapy (NPWT) on closed surgical incisions. We performed a prospective randomized controlled clinical trial comparing NPWT to standard dry dressings on surgical incisions.
   Methods: Patients presenting to a high-volume wound center were randomized to receive either a V. A. C. (KCI, San Antonio, TX) or a standard dry dressing over their incision at the conclusion of surgery. These were primarily high-risk patients with multiple comorbidities. The 2 groups were compared, and all incisions were evaluated for infection and dehiscence postoperatively.
   Results: Eighty-one patients were included for analysis. Thirty-seven received dry dressings, and 44 received NPWT. Seventy-four of these underwent lower extremity wound closure. Average follow-up was 113 days. There were no differences in demographic, preoperative, and operative variables between groups; 6.8% of the NPWT group and 13.5% of the dry dressing group developed wound infection, but this was not statistically significant (P = 0.46). There was no difference in time to develop infection between the groups. There was no statistical difference in dehiscence between NPWT and dry dressing group (36.4% vs 29.7%; P = 0.54) or mean time to dehiscence between the 2 groups (P = 0.45). Overall, 35% of the dry dressing group and 40% of the NPWT group had a wound infection, dehiscence, or both. Of these, 9 in the NPWT group (21%) and 8 in the dry dressing group (22%) required reoperation.
   Conclusions: There is a significant rate of postoperative infection and dehiscence in patients with multiple comorbidities. There was no difference in the incidence of infection or dehiscence between the NPWT and dry dressing group. This study is registered with ClinicalTrials.gov. The unique registration number is NCT01366105.
C1 [Masden, Derek; Goldstein, Jesse; Endara, Mathew; Xu, Kyle; Steinberg, John; Attinger, Christopher] Georgetown Univ Hosp, Dept Plast Surg, Washington, DC 20007 USA.
C3 Georgetown University
RP Attinger, C (通讯作者)，Georgetown Univ Hosp, Dept Plast Surg, 3800 Reservoir Rd NW,Bless Bldg,1st Floor, Washington, DC 20007 USA.
EM cattinger@aol.com
RI Xu, Kyle/HCI-5630-2022
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NR 53
TC 88
Z9 104
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JUN
PY 2012
VL 255
IS 6
BP 1043
EP 1047
DI 10.1097/SLA.0b013e3182501bae
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 943DQ
UT WOS:000304101100016
PM 22549748
DA 2026-07-24
ER
PT J
AU Wilkes, RP
   Kilpadi, DV
   Zhao, YB
   Kazala, R
   McNulty, A
AF Wilkes, Robert Peyton
   Kilpadi, Deepak V.
   Zhao, Yabin
   Kazala, Richard
   McNulty, Amy
TI Closed Incision Management With Negative Pressure Wound Therapy (CIM):
   Biomechanics
SO SURGICAL INNOVATION
LA English
DT Article
DE biomedical engineering; hernias; orthopedic surgery; Cesarean section;
   dehiscence; finite element analysis; tissue mechanics; negative pressure
   wound therapy; CIM; modeling
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISIONS; SKIN; TENSION; MODELS;
   TRIAL
AB A novel closed incision management with negative pressure wound therapy (CIM) has been developed for convenient use with closed incisions that has the potential to be beneficial for patients at risk for postoperative complications. Incisions are typically under lateral tension. This study explored the biomechanical mechanisms by which integrity of the incisional closure is enhanced by CIM. CIM was hypothesized to affect local stresses around closed incisions in a beneficial manner. Finite element analyses (FEA) indicated that application of CIM decreased the lateral stresses similar to 50% around the incision and changed the direction of the stresses to a distribution that is typical of intact tissue. Bench evaluations corroborated findings that CIM significantly increased the force required to disrupt the closed incision by (similar to)50% as compared with closure alone. In conclusion, using 2 FEAs and bench modeling, CIM was shown to reduce and normalize tissue stresses and bolster appositional forces at the incision.
C1 [Wilkes, Robert Peyton] Kinet Concepts Inc, Global Res & Dev, San Antonio, TX 78249 USA.
RP Wilkes, RP (通讯作者)，Kinet Concepts Inc, Global Res & Dev, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM robert.wilkes@kci1.com
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NR 46
TC 217
Z9 263
U1 0
U2 17
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD MAR
PY 2012
VL 19
IS 1
BP 67
EP 75
DI 10.1177/1553350611414920
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 943SP
UT WOS:000304145800014
PM 21868417
DA 2026-07-24
ER
PT J
AU Stone, PA
   Mousa, AY
   Hass, SM
   Dearing, D
   Campbell, JR
   Parker, A
   Thompson, S
   AbuRahma, AF
AF Stone, Patrick A.
   Mousa, Albeir Y.
   Hass, Stephen M.
   Dearing, Daniel
   Campbell, James R., II
   Parker, Ashley
   Thompson, Stephanie
   AbuRahma, Ali F.
TI Antibiotic-loaded polymethylmethacrylate beads for the treatment of
   extracavitary vascular surgical site infections
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 25th Annual Meeting of the Eastern-Vascular-Society
CY SEP 22-24, 2011
CL Washington, DC
SP Eastern Vasc Soc
ID PROSTHETIC GRAFT INFECTIONS; STAPHYLOCOCCUS-AUREUS; CURRENT OPTIONS;
   MUSCLE FLAPS; MANAGEMENT; PREVENTION; REPLACEMENT; VANCOMYCIN; EFFICACY;
   BYPASS
AB Objective: This study assessed the efficacy of antibiotic-loaded polymethylmethacrylate (PMMA) beads in the treatment of lower extremity vascular surgical site infections (VSSIs).
   Methods: This was a retrospective review of all patients with a VSSI of a lower extremity bypass treated with antibiotic-loaded PMMA beads and culture-specific antibiotics during a 4.5-year period. Data collected included patient demographics, comorbidities, site of initial graft infection, symptoms and signs at presentation, initial and additional surgical debridement, wound culture results, type of antibiotic beads implanted, and graft treatment strategy, comprising conduit preservation or in situ replacement, with associated soft tissue management by muscle flap or vacuum-assisted closure. Primary outcome measures included death, recurrent infection, and limb salvage.
   Results: Forty patients developed 42 extracavitary lower extremity VSSIs (bilateral groin infections in two). Patients were treated according to our treatment algorithm with antibiotic-impregnated PMMA beads. Previous reconstructions included nine aortofemoral bypasses (groin infection only), 20 infrainguinal bypasses, five extra-anatomic bypasses, five femoral interpositions, two combined inflow-outflow bypass procedures, and one patch angioplasty with VSSI. Cultures isolated 59 pathogens (39 gram-positive, 18 gram-negative, 2 Candida spp). Methicillin-resistant Staphylococcus aureus was cultured from 10 VSSs (23.8%) overall and from 27.7% of those patients with attempted graft preservation or in situ reconstructions. Two patients (4.8%) had no growth despite clinical signs of infection. Repeat VSS exploration and culture results led to an average of 1.4 bead replacements before definitive treatment. Final treatment strategy included graft preservation of patent bypasses in 28, partial graft excision with in situ replacement in eight, graft removal only with residual graft remaining at implant site (ie, incorporated anastomotic conduit, 11.9%) in five, and extra-anatomic reconstruction in one. Sartorius muscle flap was performed in 14 groin infections (37.8%). The 30-day mortality was 0%, and limb loss was 7.1% (n = 3). At the median follow-up of 17 months, the limb loss was 21.4% and the recurrent infection rate was 19.4% (seven of 36) in those with attempted graft preservation or in situ replacement.
   Conclusions: Antibiotic-loaded PMMA beads may serve as an adjunct in the management of VSSIs and may also expand treatment options for graft preservation or in situ reconstruction, with expected recurrent infection rate approaching 20%. Further experience with this adjunct may help elucidate its role in the management of this complicated problem, including the need for bead exchanges, until perigraft cultures are free of microbes. (J Vasc Surg 2012;55:1706-11.)
C1 [Stone, Patrick A.; Mousa, Albeir Y.; Hass, Stephen M.; Dearing, Daniel; Campbell, James R., II; Parker, Ashley; Thompson, Stephanie; AbuRahma, Ali F.] W Virginia Univ, Dept Vasc Surg, Charleston, WV 25304 USA.
C3 West Virginia University
RP Stone, PA (通讯作者)，W Virginia Univ, Dept Vasc Surg, 3100 MacCorkle Ave, Charleston, WV 25304 USA.
EM pstone0627@yahoo.com
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NR 24
TC 39
Z9 43
U1 0
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD JUN
PY 2012
VL 55
IS 6
BP 1706
EP 1711
DI 10.1016/j.jvs.2011.12.037
PG 6
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA 944MF
UT WOS:000304206000023
PM 22421462
OA Bronze
DA 2026-07-24
ER
PT J
AU Martindell, D
AF Martindell, Denise
TI The Safe Use of Negative-Pressure Wound Therapy
SO AMERICAN JOURNAL OF NURSING
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DEVICES
AB The Pennsylvania Patient Safety Reporting System is a confidential, statewide Internet reporting system to which all Pennsylvania hospitals, outpatient-surgery facilities, and birthing centers, as well as some abortion facilities, must file information on medical errors. Safety Monitor is a column from Pennsylvania's Patient Safety Authority, the authority that informs nurses on issues that can affect patient safety and presents strategies they can easily integrate into practice. For more information on the authority, visit www.patientsafetyauthority.org. For the original article discussed in this column or for other articles on patient safety, click on "Patient Safety Advisories" and then "Advisory Library" in the left-hand navigation menu.
C1 ECRI Inst, Plymouth Meeting, PA USA.
RP Martindell, D (通讯作者)，ECRI Inst, Plymouth Meeting, PA USA.
EM dmartindell@ecri.org
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NR 18
TC 6
Z9 8
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0002-936X
EI 1538-7488
J9 AM J NURS
JI Am. J. Nurs.
PD JUN
PY 2012
VL 112
IS 6
BP 59
EP 63
DI 10.1097/01.NAJ.0000415134.85429.9d
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 948TQ
UT WOS:000304525900025
PM 22627354
DA 2026-07-24
ER
PT J
AU Hogan, N
   Byrnes, V
   Hussey, A
   Joyce, M
AF Hogan, Niamh
   Byrnes, Valerie
   Hussey, Alan
   Joyce, Myles
TI Surgical management of gluteal metastatic cutaneous Crohn's disease
SO JOURNAL OF CROHNS & COLITIS
LA English
DT Article
DE Metastatic cutaneous Crohn's; Gluteal
ID HIDRADENITIS SUPPURATIVA; INFLIXIMAB; PERINEAL
AB Metastatic cutaneous Crohn's disease is a rare entity first described by McCallum et al. in 1976. It is diagnosed when histologically characteristic granulomata are seen at a site not contiguous with inflammatory disease in the gastrointestinal tract. We herein report presentation, diagnosis and management of a 28 year old lady with disabling, symptomatic cutaneous Crohn's of the buttocks and natal cleft refractory to Infliximab therapy. To the best of our knowledge only four other adult cases have been reported in the literature of metastatic cutaneous Crohn's disease of the buttock area distant from a flexure or area of skin apposition. The differential diagnosis in this case was Hidradenitis Suppurativa. A good cosmetic result and excellent symptom control were achieved with extensive debridement, wide local excision, vacuum assisted closure and delayed skin grafting. (C) 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
C1 [Hogan, Niamh; Joyce, Myles] Univ Coll Hosp Galway, Dept Colorectal Surg, Galway, Ireland.
   [Byrnes, Valerie] Univ Coll Hosp Galway, Dept Gastroenterol, Galway, Ireland.
   [Hussey, Alan] Univ Coll Hosp Galway, Dept Plast Surg, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Ollscoil na
   Gaillimhe-University of Galway; Ollscoil na Gaillimhe-University of
   Galway
RP Hogan, N (通讯作者)，Univ Coll Hosp Galway, Dept Colorectal Surg, Galway, Ireland.
EM niamhogan@gmail.com
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NR 19
TC 3
Z9 3
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1873-9946
J9 J CROHNS COLITIS
JI J. Crohns Colitis
PD JUN
PY 2012
VL 6
IS 5
BP 617
EP 620
DI 10.1016/j.crohns.2011.12.015
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 950ZF
UT WOS:000304689700017
PM 22398091
OA hybrid
DA 2026-07-24
ER
PT J
AU De Brabandere, K
   Jacobs-Tulleneers-Thevissen, D
   Czapla, J
   La Meir, M
   Delvaux, G
   Wellens, F
AF De Brabandere, Kristof
   Jacobs-Tulleneers-Thevissen, Daniel
   Czapla, Jens
   La Meir, Mark
   Delvaux, Georges
   Wellens, Francis
TI Negative-Pressure Wound Therapy and Laparoscopic Omentoplasty for Deep
   Sternal Wound Infections after Median Sternotomy
SO TEXAS HEART INSTITUTE JOURNAL
LA English
DT Article
DE Coronary artery bypass grafting; debridement; deep sternal wound
   infection; laparoscopy; mediastinitis; negative-pressure wound therapy;
   omentoplasty; surgical flaps; surgical wound infection/mortality/surgery
ID VACUUM-ASSISTED CLOSURE; OMENTAL-FLAP; MUSCLE FLAPS; RISK-FACTORS;
   MEDIASTINITIS; RECONSTRUCTION
AB Deep sternal wound infection remains one of the most serious complications in patients who undergo median sternotomy for coronary artery bypass surgery.
   We describe our experience in treating 6 consecutive patients with our treatment protocol that combines aggressive debridement, broad-spectrum antibiotics, negative-pressure wound therapy omentoplasty with laparoscopically harvested omentum, and the use of bilateral pectoral muscle advancement flaps.
   The number of debridements needed in order to attain clinically clean wounds and negative cultures varied between 1 and 10, with a median of 5. The length of stay after omentoplasty and bilateral pectoral muscle advancement flap placement varied between 11 and 22 days. One of the 6 patients developed a small wound dehiscence that was treated conservatively No bleeding related to vacuum-assisted closure therapy was identified. Three patients had pneumonia. Two of the 3 patients had an episode of acute renal failure. The 30-day mortality rate was zero, although 1 patient died in the hospital 43 days after the re-constructive surgery of multiple-organ failure due to pneumonia that was induced by end-stage pulmonary fibrosis. No patient died between hospital discharge and the most recent follow-up date (4-12 mo). Late local follow-up results, both functional and aesthetic, were good.
   We conclude that negative-pressure wound therapy-in combination with omentoplasty using laparoscopically harvested omentum and with the use of bilateral pectoral advancement flaps-is a valuable technique in the treatment of deep sternal wound infection because it produces good functional and aesthetic results. (Tex Heart Inst J 2012;39 (3):367-71)
C1 [De Brabandere, Kristof; Jacobs-Tulleneers-Thevissen, Daniel; Delvaux, Georges] Univ Ziekenhuis Brussel, Dept Gen & Abdominal Surg, B-1090 Brussels, Belgium.
   [Czapla, Jens; La Meir, Mark; Wellens, Francis] Univ Ziekenhuis Brussel, Dept Cardiac Surg, B-1090 Brussels, Belgium.
C3 University Hospital Brussels; Vrije Universiteit Brussel; University
   Hospital Brussels; Vrije Universiteit Brussel
RP De Brabandere, K (通讯作者)，Univ Ziekenhuis Brussel, Dept Gen & Abdominal Surg, Laarbeeklaan 101, B-1090 Brussels, Belgium.
EM kristof.de.brabandere@gmail.com
RI Jacobs-Tulleneers-Thevissen, Daniel/GNH-4840-2022; La Meir,
   Mark/CAH-0364-2022
OI Jacobs-Tulleneers-Thevissen, Daniel/0000-0001-5758-9547; La Meir,
   Mark/0000-0002-6261-5110
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NR 28
TC 11
Z9 14
U1 0
U2 3
PU TEXAS HEART INST
PI HOUSTON
PA PO BOX 20345, HOUSTON, TX 77225-0345 USA
SN 1526-6702
J9 TEX HEART I J
JI Tex. Heart Inst. J.
PD JUN
PY 2012
VL 39
IS 3
BP 367
EP 371
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 955VN
UT WOS:000305049100012
PM 22719146
DA 2026-07-24
ER
PT J
AU de Weerd, L
   Kjæve, J
   Nergård, S
AF de Weerd, Louis
   Kjaeve, Jorn
   Nergard, Solveig
TI The parachute design as a new extraperitoneal method of closing a
   recalcitrant high-output enterocutaneous fistula: report of a case
SO SURGERY TODAY
LA English
DT Article
DE Enterocutaneous fistula; Muscle flap; Vacuum-assisted closure system
ID GASTROINTESTINAL FISTULAS; MANAGEMENT; NUTRITION; SURGERY
AB We introduce a new method for closure of a recalcitrant high-output jejunal enterocutaneous fistula. First, a transposed rectus abdominis muscle is sutured into the fistula opening using a parachuting technique, then the muscle is covered with a skin graft and temporarily immobilized to the fistula wall and abdominal wall with a negative pressure device. This extraperitoneal method provides tension-free closure of the fistula with well-vascularized tissue, without compromising the intestinal lumen. No bowel is resected. This new technique allows for early mobilization and recommencement of enteral nutrition.
C1 [de Weerd, Louis; Nergard, Solveig] Univ Hosp N Norway, Dept Plast Surg & Hand Surg, N-9038 Tromso, Norway.
   [Kjaeve, Jorn] Univ Hosp N Norway, Dept Surg Gastroenterol, N-9038 Tromso, Norway.
C3 UiT The Arctic University of Tromso; University Hospital of North
   Norway; UiT The Arctic University of Tromso; University Hospital of
   North Norway
RP de Weerd, L (通讯作者)，Univ Hosp N Norway, Dept Plast Surg & Hand Surg, N-9038 Tromso, Norway.
EM louis.deweerd@unn.no
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   Cohen M, 2006, CLIN PLAST SURG, V33, P295, DOI 10.1016/j.cps.2005.12.001
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NR 14
TC 3
Z9 3
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
J9 SURG TODAY
JI Surg. Today
PD JUL
PY 2012
VL 42
IS 7
BP 681
EP 685
DI 10.1007/s00595-012-0128-6
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 958HD
UT WOS:000305226200011
PM 22294423
DA 2026-07-24
ER
PT J
AU Dorafshar, AH
   Franczyk, M
   Gottlieb, LJ
   Wroblewski, KE
   Lohman, RF
AF Dorafshar, Amir H.
   Franczyk, Mieczyslawa
   Gottlieb, Lawrence J.
   Wroblewski, Kristen E.
   Lohman, Robert F.
TI A Prospective Randomized Trial Comparing Subatmospheric Wound Therapy
   With a Sealed Gauze Dressing and the Standard Vacuum-Assisted Closure
   Device
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; wound healing
ID NEGATIVE-PRESSURE; STERNAL WOUNDS; SYSTEM; BRIDGE
AB Objective: Two methods of subatmospheric pressure wound therapy-wall suction applied to a sealed gauze dressing (GSUC) and the vacuum-assisted closure device (VAC)-were compared in hospitalized patients at University of Chicago Medical Center.
   Summary of Background Data: VAC therapy is widely used, but can be expensive and difficult to apply; it also fails in some patients.
   Methods: A randomized prospective study of 87 patients (N = 45 in the GSUC arm and N = 42 in the VAC arm) was undertaken between October 2006 and May 2008. The study comprised patients with acute wounds resulting from trauma, dehiscence, or surgery.
   Results: Demographics and wound characteristics were similar in both groups. There were significant reductions in wound surface area and volume in each group. In the GSUC group, the reductions in wound surface area and volume were 4.5%/day and 8.4%/day, respectively (P < 0.001 for both), and in the VAC group, this was 4.9%/day and 9.8%/day, respectively (P < 0.001 for both). The reductions in wound surface area and volume were similar in both groups (P = 0.60 and 0.19, respectively, for the group-by-time interaction). The estimated difference (VAC - GSUC) was 0.4% (95% confidence interval: -1.0, 1.7) for wound surface area and 1.4% (95% confidence interval: -0.7, 3.5) for volume. The mean cost per day for GSUC therapy was $4.22 versus $96.51 for VAC therapy (P < 0.01) and the average time required for a GSUC dressing change was 19 minutes versus 31 minutes for a VAC dressing change (P < 0.01). The sum of pain intensity differences was 0.50 in the GSUC group compared with 1.73 for the VAC group (P = 0.02).
   Conclusions: GSUC is noninferior to VAC with respect to changes in wound volume and surface area in an acute care setting. In addition, GSUC dressings were easier to apply, less expensive, and less painful.
C1 [Lohman, Robert F.] Cleveland Clin, Dept Plast & Reconstruct Surg, Cleveland, OH 44106 USA.
   [Lohman, Robert F.] Cleveland Clin, Dept Orthopaed Surg, Cleveland, OH 44106 USA.
   [Dorafshar, Amir H.] Johns Hopkins Med Inst, Div Plast & Reconstruct Surg, Baltimore, MD 21205 USA.
   [Franczyk, Mieczyslawa] Univ Chicago, Dept Therapy Serv, Chicago, IL 60637 USA.
   [Gottlieb, Lawrence J.] Univ Chicago, Sect Plast & Reconstruct Surg, Chicago, IL 60637 USA.
   [Wroblewski, Kristen E.] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Johns Hopkins
   University; Johns Hopkins Medicine; University of Chicago; University of
   Chicago; University of Chicago
RP Lohman, RF (通讯作者)，Cleveland Clin Fdn, Dept Plast & Reconstruct Surg, 9500 Euclid Ave,Desk A-60, Cleveland, OH 44195 USA.
EM lohmanr@ccf.org
RI Dorafshar, Amir/AAP-2657-2021
OI Dorafshar, Amir/0000-0001-7045-3601
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NR 31
TC 56
Z9 63
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUL
PY 2012
VL 69
IS 1
BP 79
EP 84
DI 10.1097/SAP.0b013e318221286c
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 961RJ
UT WOS:000305485200019
PM 21712704
DA 2026-07-24
ER
PT J
AU Woods, S
   Marques, AID
   Renwick, MG
   Argyle, SA
   Yool, DA
AF Woods, Samantha
   Marques, Ana I. de Castro
   Renwick, Mala G.
   Argyle, Sally A.
   Yool, Donald A.
TI Nanocrystalline silver dressing and subatmospheric pressure therapy
   following neoadjuvant radiation therapy and surgical excision of a
   feline injection site sarcoma
SO JOURNAL OF FELINE MEDICINE AND SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND CLOSURE
AB Clinical summary This is the first clinical report of use of a combination of nanocrystalline silver and subatmospheric pressure therapy to treat a resistant wound infection, following tumour removal and radiation therapy, in a difficult-to-manage surgical site in a cat.
   Practical relevance The therapy was well tolerated and the authors suggest it is a valid treatment protocol for management of non-healing or infected wounds in the cat.
C1 [Woods, Samantha; Marques, Ana I. de Castro; Renwick, Mala G.; Argyle, Sally A.; Yool, Donald A.] Univ Edinburgh, Div Vet Clin Sci, Royal Dick Sch Vet Studies, Easter Bush Vet Ctr,Hosp Small Anim, Roslin EH25 9RG, Midlothian, Scotland.
C3 University of Edinburgh
RP Woods, S (通讯作者)，Univ Edinburgh, Div Vet Clin Sci, Royal Dick Sch Vet Studies, Easter Bush Vet Ctr,Hosp Small Anim, Roslin EH25 9RG, Midlothian, Scotland.
EM samantha.woods@ed.ac.uk
RI Woods, Samantha/MFI-5154-2025; Yool, Donald/PKQ-5683-2026; Renwick,
   Mala/HNQ-7074-2023
OI Woods, Samantha/0009-0003-8265-5819; Yool, Donald/0000-0002-3562-9111; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 24
TC 6
Z9 7
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1098-612X
EI 1532-2750
J9 J FELINE MED SURG
JI J. Feline Med. Surg.
PD MAR
PY 2012
VL 14
IS 3
BP 214
EP 218
DI 10.1177/1098612X12439269
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 962FL
UT WOS:000305526800006
PM 22370864
OA Green Submitted, Green Published, Bronze
DA 2026-07-24
ER
PT J
AU Gupta, S
AF Gupta, Subhas
TI Special Issue: The Impact of Evolving V.A.C® Therapy Technology on
   Outcomes in Wound Care Prologue
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Wound care
ID VACUUM-ASSISTED CLOSURE; ANGIOGENESIS; STRESS; STATE
AB In May 2011, an international panel of wound care experts from multiple disciplines convened to develop this document to summarise the evolution of negative pressure wound therapy (NPWT) technology devices over the past 15 years, specifically concentrating on the V.A.C.(R) Therapy (KCI USA, Inc., San Antonio, TX) family of products. The aim of this document, which will be comprised of six articles, is to describe appropriate use of current technology options across a variety of wound types. The articles will include literature reviews, initiation criteria, treatment outcomes, technical pearls and clinical cases that will show the enhanced outcomes and potential economic value of the various NPWT technologies in use today.
C1 Loma Linda Univ, Sch Med, Dept Plast Surg, Loma Linda, CA 92354 USA.
C3 Loma Linda University
RP Gupta, S (通讯作者)，Loma Linda Univ, Sch Med, Dept Plast Surg, 11175 Campus Dr,Coleman Pavil 21226, Loma Linda, CA 92354 USA.
EM plsurgeon@gmail.com
RI Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922
FU Kinetic Concepts, Inc.
FX Dr SG has a consulting agreement with Kinetic Concepts, Inc. for the
   development of this article. This article is part of an educational
   supplement funded by Kinetic Concepts, Inc. to provide an overview of
   the V.A.C.(R) Therapy family of products for new users in developing
   markets. This supplement is targeted for distribution at the 2012 World
   Union of Wound Healing Societies (WUWHS) conference.
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NR 26
TC 7
Z9 8
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2012
VL 9
SU 1
SI SI
BP III
EP VII
DI 10.1111/j.1742-481X.2012.00978.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 962UX
UT WOS:000305573000001
PM 22727140
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Armstrong, DG
   Andros, G
AF Armstrong, David G.
   Andros, George
TI Use of negative pressure wound therapy to help facilitate limb
   preservation
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Diabetic foot ulcer; Limb preservation; Negative pressure wound therapy;
   Venous leg ulcer
ID VACUUM-ASSISTED CLOSURE; FOOT ULCERS; PLANTAR PRESSURE; AMPUTATION;
   CARE; MULTICENTER; MANAGEMENT; PREVENT; TRIAL; TEAM
AB Because of changes in demography, non-communicable diseases cause more deaths worldwide than infectious disease for the first time in history. One of the most prevalent of these maladies is diabetes mellitus, which resulted in 4.6 million deaths in 2011. There will be approximately 552 million people with diabetes worldwide by 2030. For these patients, one of the most common severe complications will be a foot wound. Patients with diabetes have at least a 25% lifetime risk of developing a foot ulcer. Many of these infections go on to amputation. Those patients have a 50% mortality rate in the 5 years following the initial amputation. Indeed, these problems are costly as well. In 2010, spending on diabetes was estimated to account for 11.6% of the total health care expenditure in the world. This review merges scientific evidence with expert experience to show the role of negative pressure wound therapy using reticulated open cell foam (V.A.C.(R) Therapy, KCI USA, Inc., San Antonio, TX) in limb preservation.
C1 [Armstrong, David G.] Univ Arizona, Coll Med, Dept Surg, Tucson, AZ 85724 USA.
   [Andros, George] Valley Presbyterian Hosp, Amputat Prevent Ctr, Van Nuys, CA USA.
C3 University of Arizona
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, Dept Surg, 1501 N Campbell Ave, Tucson, AZ 85724 USA.
EM armstrong@usa.net
FU Kinetic Concepts, Inc.
FX Dr DA and Dr GA have Consulting agreements with Kinetic Concepts, Inc.
   This article is part of an educational supplement funded by Kinetic
   Concepts, Inc. to provide an overview of the V.A.C.(R) Therapy family of
   products for new users in developing markets. Targeted for distribution
   at the 2012 World Union of Wound Healing Societies (WUWHS) conference,
   this supplement article presents a brief literature review and clinical
   experience treating diabetic foot and leg ulcers with V.A.C.(R) Therapy.
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   Rogers LC, 2010, J VASC SURG, V52, p23S, DOI 10.1016/j.jvs.2010.06.004
   Rogers LC, 2010, J AM PODIAT MED ASSN, V100, P101, DOI 10.7547/1000101
   Schwien T, 2005, OSTOMY WOUND MANAG, V51, P47
   Singh N, 2005, JAMA-J AM MED ASSOC, V293, P217, DOI 10.1001/jama.293.2.217
   Sumpio BE, 2010, J VASC SURG, V51, P1504, DOI 10.1016/j.jvs.2010.04.010
   Sumpio BE, 2009, WOUNDS, P3
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   Wu Stephanie C, 2005, Curr Diab Rep, V5, P423, DOI 10.1007/s11892-005-0049-5
   Zhang P., 2009, Economic impact of diabetes in IDF Diabetes Atlas, Vfourth
NR 44
TC 11
Z9 15
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2012
VL 9
SU 1
SI SI
BP 1
EP 7
DI 10.1111/j.1742-481X.2012.01015.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 962UX
UT WOS:000305573000002
PM 22727134
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Gupta, S
   Ichioka, S
AF Gupta, Subhas
   Ichioka, Shigeru
TI Optimal use of negative pressure wound therapy in treating pressure
   ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Pressure ulcer; Wound healing
ID PROSPECTIVE RANDOMIZED-TRIAL; VACUUM-ASSISTED CLOSURE; BED PREPARATION;
   HOME-CARE; MANAGEMENT; IMPACT
AB Pressure ulcers (PrUs) are a challenging health concern for both the clinician and the patient. The exact incidence and prevalence of PrUs varies widely among specific clinical populations, from 0.4% to 38% in acute care, from 2.2% to 24% in long-term care and from 0% to 17% in home care. The economic impact of these wounds is impressive with an estimated cost of $11 to $17.2 billion annually in the USA. Guidelines from the National Pressure Ulcer Advisory Panel and European Pressure Ulcer Advisory Panel have provided recommendations for the prevention and treatment of PrUs. Negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF; V.A.C.(R) Therapy, KCI USA, Inc. San Antonio, TX) has been successfully used for managing PrUs. This review combines expert opinion with scientific evidence to describe the use of NPWT/ROCF in patients with PrUs.
C1 [Gupta, Subhas] Loma Linda Univ, Sch Med, Dept Plast Surg, Loma Linda, CA 92354 USA.
   [Ichioka, Shigeru] Saitama Med Univ, Dept Plast Surg, Kawagoe, Saitama, Japan.
C3 Loma Linda University; Saitama Medical University
RP Gupta, S (通讯作者)，Loma Linda Univ, Sch Med, Dept Plast Surg, 11175 Campus Dr,Coleman Pavil 21226, Loma Linda, CA 92354 USA.
EM plsurgeon@gmail.com
RI Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922
FU Kinetic Concepts, Inc.; Grants-in-Aid for Scientific Research [23592652]
   Funding Source: KAKEN
FX Dr SG has a consulting agreement with Kinetic Concepts, Inc. for the
   development of this article, and Dr SI is a Key Opinion Leader in Japan.
   This article is part of an educational supplement funded by Kinetic
   Concepts, Inc. to provide an overview of the V.A.C.(R) Therapy family of
   products for new users in developing markets. This supplement is
   targeted for distribution at the 2012 World Union of Wound Healing
   Societies (WUWHS) conference.
CR [Anonymous], 2010, VAC THER CLIN GUID R
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], 2012, OV SCI CLIN EV UT KC
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   Langemo DK, 2005, WOUNDS, V17, P3
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NR 27
TC 14
Z9 21
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2012
VL 9
SU 1
SI SI
BP 8
EP 16
DI 10.1111/j.1742-481X.2012.01012.x
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 962UX
UT WOS:000305573000003
PM 22727135
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Demetriades, D
AF Demetriades, Demetrios
TI Total management of the open abdomen
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal compartment syndrome; Damage control; Negative pressure
   therapy; Open abdomen
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM-ASSISTED CLOSURE; FASCIAL CLOSURE;
   PACK TECHNIQUE; THERAPY
AB The management of complex abdominal problems with the open abdomen (OA) technique has become a routine procedure in surgery. The number of cases treated with an OA has increased dramatically because of the popularisation of damage control for life-threatening conditions, recognition and treatment of intra-abdominal hypertension and abdominal compartment syndrome and new evidence regarding the management of severe intra-abdominal sepsis. Although OA has saved numerous lives and has addressed many problems related to the primary pathology, this technique is also associated with serious complications. New knowledge about the pathophysiology of the OA and the development of new technologies for temporary abdominal wall closure (e.g. ABThera (TM) Open Abdomen Negative Pressure Therapy; KCI USA Inc., San Antonio, TX) has helped improve the management and outcomes of these patients. This review will merge expert physician opinion with scientific evidence regarding the total management of the OA.
C1 Univ So Calif, Keck Sch Med, Dept Surg, Div Trauma Emergency Surg & Surg Crit Care, Los Angeles, CA 90033 USA.
C3 University of Southern California
RP Demetriades, D (通讯作者)，Univ So Calif, Keck Sch Med, Dept Surg, Div Trauma Emergency Surg & Surg Crit Care, 1510 San Pablo St,HCC 514, Los Angeles, CA 90033 USA.
EM demetria@usc.edu
FU Kinetic Concepts Inc.
FX Dr DD has a consulting agreement with Kinetic Concepts, Inc. This
   article is part of an educational supplement funded by Kinetic Concepts
   Inc. to provide an overview of the V.A.C.(R) Therapy family of products
   for new users in developing markets.
CR Adkins AL, 2004, AM SURGEON, V70, P137
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NR 26
TC 62
Z9 71
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2012
VL 9
SU 1
SI SI
BP 17
EP 24
DI 10.1111/j.1742-481X.2012.01018.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 962UX
UT WOS:000305573000004
PM 22727136
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Gabriel, A
AF Gabriel, Allen
TI Integrated negative pressure wound therapy system with volumetric
   automated fluid instillation in wounds at risk for compromised healing
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE At-risk wounds; Infected wounds; Negative pressure wound therapy with
   instillation
ID CASE SERIES
AB Nearly all wounds are at risk for compromised healing due to excessive exudation, oedema, contaminants and presence of inflammatory mediators. Compromised wounds have the potential to develop complications, such as infection, which may lead to delayed wound healing, prolonged hospitalisation and more frequent readmissions. It is generally believed that the wound advances from contamination to colonisation when the bacteria on the wound's surface begin to replicate and increase their metabolic activity. Heavy bacterial bioburden increases the metabolic requirements, stimulates a proinflammatory environment and encourages the in-migration of monocytes, macrophages and leukocytes all of which can negatively impact wound healing. Bacteria also secrete harmful cytokines which can lead to vasoconstriction and decreased blood flow. Thus, controlling or preventing infections is essential for normal wound healing process to occur. While the mainstay of treating wound infection has historically included intravenous, oral and/or topical antimicrobials in addition to frequent gauze dressing changes, a shift towards wound management with advanced modalities, such as negative pressure wound therapy (NPWT), has occurred during the past decade. This review will provide expert opinion and scientific support for the use of NPWT with instillation (NPWTi; V.A.C. Instill (R) Wound Therapy and V.A.C. VeraFlo (TM) Therapy, KCI USA, Inc., San Antonio, TX) for the treatment of at-risk and complicated wounds.
C1 SW Med Grp Plast Surg, Dept Plast Surg, Vancouver, WA 98664 USA.
RP Gabriel, A (通讯作者)，SW Med Grp Plast Surg, Dept Plast Surg, 505 NE 87th Ave,Suite 250, Vancouver, WA 98664 USA.
EM gabrielallen@yahoo.com
RI Gabriel, Allen/AFK-3548-2022
FU Kinetic Concepts, Inc.
FX Dr AG has a Consulting agreement with Kinetic Concepts, Inc. This
   article is part of an educational supplement funded by Kinetic Concepts,
   Inc. to provide an overview of the V.A.C.(R) Therapy family of products
   for new users in developing markets. Targeted for distribution at the
   2012 World Union of Wound Healing Societies (WUWHS) conference, this
   supplement article presents a brief literature review and clinical
   experience treating compromised wounds using V.A.C.(R) Therapy with
   instillation (i.e. VA.C. Instill (R) Wound Therapy and V.A.C. VeraFlo
   (TM) Therapy).
CR [Anonymous], 2010, HLTH CAR ACQ INF
   Bernstein BH, 2005, WOUNDS, V17, P37
   D'Hondt M, 2011, TECH COLOPROCTOL, V15, P75, DOI 10.1007/s10151-010-0662-4
   Gabriel A., 2011, CLIN S ADV SKIN WOUN
   Gabriel A, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00628.x
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NR 15
TC 30
Z9 34
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2012
VL 9
SU 1
SI SI
BP 25
EP 31
DI 10.1111/j.1742-481X.2012.01014.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 962UX
UT WOS:000305573000005
PM 22727137
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Stannard, JP
   Gabriel, A
   Lehner, B
AF Stannard, James P.
   Gabriel, Allen
   Lehner, Burkhard
TI Use of negative pressure wound therapy over clean, closed surgical
   incisions
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Surgical incisions; Wound dehiscence
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; BLOOD-FLOW;
   MANAGEMENT; INFECTIONS
AB The literature has reported that surgical site infections account for 17-22% of health care-associated infections, while surgical wound dehiscence rates range from 0.25% to 3.0% (post laparatomies), 1.6% to 42.3% (post-caesarean incisions) and 0.5% to 2.5% (sternal incisions). These types of incisional complications can become a significant cost burden to the health care system because of lengthy hospital stays and readmissions, additional nursing care and added surgical procedures. Therefore, the type of therapy used for surgical incisions plays a critical role in the healing process. The success of negative pressure wound therapy (NPWT; V.A.C.(R) Therapy; KCI USA, Inc., San Antonio, TX) for open wounds has been well documented and has led to its use over clean, closed surgical incisions. This review will focus on clinician experience and literature review of incisional NPWT and will include clinical cases describing NPWT's successful use over surgical incisions.
C1 [Stannard, James P.] Univ Missouri, Missouri Orthopaed Inst, Sch Med, Dept Orthoped Surg, Columbia, MO 65212 USA.
   [Gabriel, Allen] SW Med Grp Plast Surg, Vancouver, WA USA.
   [Lehner, Burkhard] Orthoped Univ Hosp, Dept Orthoped Oncol & Sept Orthoped Surg, Heidelberg, Germany.
C3 University of Missouri System; University of Missouri Columbia; Ruprecht
   Karls University Heidelberg
RP Stannard, JP (通讯作者)，Univ Missouri, Missouri Orthopaed Inst, Sch Med, Dept Orthoped Surg, 1100 Virginia Ave, Columbia, MO 65212 USA.
EM stannardj@missouri.edu
RI ; Gabriel, Allen/AFK-3548-2022
OI Stannard, James P/0000-0001-8467-6494; 
FU Kinetic Concepts, Inc.
FX Dr JPS, Dr AG and Dr BL have Consulting agreements with Kinetic
   Concepts, Inc. This article is part of an educational supplement funded
   by Kinetic Concepts, Inc. to provide an overview of the V.A.C.(R)
   Therapy family of products for new users in developing markets. Targeted
   for distribution at the 2012 World Union of Wound Healing Societies
   (WUWHS) conference, this supplement article presents a brief literature
   review and clinical experience treating clean, closed surgical incisions
   with V.A.C.(R) Therapy or Prevena (TM) Incision Management System.
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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NR 39
TC 71
Z9 84
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2012
VL 9
SU 1
SI SI
BP 32
EP 39
DI 10.1111/j.1742-481X.2012.01017.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 962UX
UT WOS:000305573000006
PM 22727138
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Gupta, S
AF Gupta, Subhas
TI Optimal use of negative pressure wound therapy for skin grafts
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Biomatrix; Negative pressure wound therapy; Split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE; BOLSTER; TRIAL
AB Skin grafting is a technique used for transplanting human skin (i.e. epidermal and some dermal layers) from a harvest site to a recipient site. However, advancements in bioengineered matrices have also introduced alternatives to skin grafts. The method used to secure the graft, whether skin or biomatrix, is critical in reducing graft failure. During the past several years, negative pressure wound therapy using reticulated open-cell foam (NPWT/ROCF; V.A.C.(R) Therapy, KCI USA, Inc., San Antonio, TX) has become a well-established method for bolstering grafts to recipient beds and is being used more frequently over biomatrices to help improve graft outcomes. This review will combine expert opinion with scientific evidence for the use of NPWT/ROCF over grafts.
C1 Loma Linda Univ, Sch Med, Dept Plast Surg, Loma Linda, CA 92350 USA.
C3 Loma Linda University
RP Gupta, S (通讯作者)，Loma Linda Univ, Sch Med, Dept Plast Surg, 11175 Campus Dr,Coleman Pavil 21226, Loma Linda, CA 92350 USA.
EM plsurgeon@gmail.com
RI Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922
FU Kinetic Concepts, Inc.
FX Dr SG has a consulting agreement with Kinetic Concepts, Inc. for the
   development of this article. This article is part of an educational
   supplement funded by Kinetic Concepts, Inc. to provide an overview of
   the V.A.C.(R) Therapy family of products for new users in developing
   markets. This supplement is targeted for distribution at the 2012 World
   Union of Wound Healing Societies (WUWHS) conference.
CR [Anonymous], 2010, VAC THER CLIN GUID R
   Avery C, 2000, INT J ORAL MAX SURG, V29, P198, DOI 10.1016/S0901-5027(00)80092-2
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NR 20
TC 39
Z9 47
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2012
VL 9
SU 1
SI SI
BP 40
EP 47
DI 10.1111/j.1742-481X.2012.01019.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 962UX
UT WOS:000305573000007
PM 22727139
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Liu, L
   Tan, G
   Luan, FJ
   Tang, X
   Kang, PD
   Tu, CQ
   Pei, FX
AF Liu, Lei
   Tan, Gang
   Luan, Fujun
   Tang, Xin
   Kang, Pengde
   Tu, Chongqi
   Pei, Fuxing
TI The use of external fixation combined with vacuum sealing drainage to
   treat open comminuted fractures of tibia in the Wenchuan earthquake
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
ID PLATEAU FRACTURES; INTERNAL-FIXATION; ASSISTED CLOSURE; MANAGEMENT;
   CLASSIFICATION; INFECTIONS; PRESSURE; SYSTEM
AB The purpose of this study was to review the results of external fixation combined with vacuum sealing drainage (VSD) to treat patients who sustained tibial and fibular fractures in the Wenchuan earthquake.
   We retrospectively analysed 179 cases (of which 85 were classified as Gustilo grade III) of open comminuted fracture of the tibia and fibula caused by the Wenchuan earthquake. The patients were followed up for an average of 15 months; detailed records were kept on their function and recovery.
   After caring for the life-threatening injuries; fractures were treated by external fixation, with VSD used on the surface or in the cavity of the wound after debridement. Antibiotics were administered on the basis of drug sensitivity test results. After the infection had been controlled and healthy granulation tissue had developed, the patients underwent secondary suture, free skin grafting, or skin flap transfer.
   Good results can be achieved when external fixation combined with vacuum sealing drainage were used to treat open comminuted fractures of tibia and fibula in the Wenchuan earthquake.
C1 [Liu, Lei; Tan, Gang; Luan, Fujun; Tang, Xin; Kang, Pengde; Tu, Chongqi; Pei, Fuxing] Sichuan Univ, W China Hosp, Dept Orthoped, Chengdu 610041, Peoples R China.
C3 Sichuan University
RP Pei, FX (通讯作者)，Sichuan Univ, W China Hosp, Dept Orthoped, Chengdu 610041, Peoples R China.
EM gukeliulei@126.com; peifuxing@vip.163.com
OI Changchao, Dong/0000-0002-5833-4017
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NR 26
TC 23
Z9 42
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD JUL
PY 2012
VL 36
IS 7
BP 1441
EP 1447
DI 10.1007/s00264-011-1404-6
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 963EG
UT WOS:000305602300018
PM 22083371
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Gabriel, A
   Wong, WD
   Gupta, S
AF Gabriel, Allen
   Wong, Wendy
   Gupta, Subhas
TI Single-stage Reconstruction for Soft Tissue Defects: A Case Series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE negative pressure wound therapy; wound closure technique; skin
   transplantation; case series; single-stage reconstruction
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; DERMAL REGENERATION
   TEMPLATE; LOWER-EXTREMITY TRAUMA; THICKNESS SKIN-GRAFTS; INTEGRA;
   PROLIFERATION; MANAGEMENT; SURGERY; BOLSTER
AB Various techniques for obtaining expedient aesthetic coverage of soft tissue defects with limited donor site morbidity have been developed, including the use of a dermal regeneration template (DRT) as the first step in a two-stage surgical approach. Use of DRT in reconstruction has increased as a result of reports suggesting improved cosmetic results and reduced scarring compared to split-thickness skin grafts (STSG), but this approach requires a return to the operating room. To evaluate outcomes of a single-stage procedure, a prospective evaluation of patients with complicated soft tissue defects measuring < 200 cm(2) was conducted. Following trauma or resection of a tumor, 20 patients underwent single-stage reconstruction with surgical debridement and application of a single-layered DRT and a meshed STSG. Negative pressure wound therapy (NPWT) was applied as a bolster with continuous -125 mm Hg pressure for 5 days. After 5 days, traditional dressings were applied and patients were followed until healed with a minimum follow-up of 5 months to a maximum follow-up of 19 months. Participants included 20 patients (14 men, six women; average age 60 years old [range: 27-92 years]; average wound size 104.5 cm(2) [range: 40.0-180.0 cm(2)]). Wounds were located on the lower extremities (10 patients), upper extremities (seven patients), and trunk (three patients). Average graft take was 98.3% with an average take time of 5.6 days (SD 0.50). No significant differences in graft take rates between male and female patients, smokers and nonsmokers, and patients with and without diabetes mellitus were observed. Wound location also did not affect graft take rates. No wound breakdown, adverse events, or re-operation occurred during follow-up. In this case series, single-stage reconstruction using DRT, STSG, and NPWT was used with good outcomes and second-stage reconstruction surgery was avoided. Prospective, randomized, controlled clinical studies to compare the various surgical and wound care approaches to closing these tissue defects are warranted.
C1 [Gabriel, Allen] SW Med Grp, Dept Surg, Vancouver, WA USA.
   [Wong, Wendy; Gupta, Subhas] Loma Linda Univ, Med Ctr, Dept Plast Surg, Loma Linda, CA USA.
C3 Loma Linda University
RP Gabriel, A (通讯作者)，505 NE 87th Ave,Suite 250, Vancouver, WA 98664 USA.
EM gabrielallen@yahoo.com
RI Gabriel, Allen/AFK-3548-2022; Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 39
TC 6
Z9 8
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2012
VL 58
IS 6
BP 30
EP +
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 967AY
UT WOS:000305879700007
PM 22688857
DA 2026-07-24
ER
PT J
AU Benech, A
   Arcuri, F
   Poglio, G
   Brucoli, M
   Guglielmetti, R
   Crespi, MC
   Pia, F
AF Benech, A.
   Arcuri, F.
   Poglio, G.
   Brucoli, M.
   Guglielmetti, R.
   Crespi, M. C.
   Pia, F.
TI Vacuum-assisted closure therapy in reconstructive surgery
SO ACTA OTORHINOLARYNGOLOGICA ITALICA
LA English
DT Article
DE Fibular free flap; Subatmospheric pressure; Maxillofacial wound; VAC
   therapy
ID PRESSURE WOUND THERAPY; PROLIFERATION; FOUNDATION; MANAGEMENT; FRACTURES
AB In 1997, supported by experimental work, Argenta published a clinical report describing a variety of complicated wounds whose treatment responded successfully to negative pressure dressings using a vacuum-assisted closure system (VAC) (Kinetic Concepts Inc., San Antonio, TX). This system has been successfully used in the fields of orthopaedics and traumatology, general surgery, plastic and reconstructive surgery and gynaecology/obstetrics for a large variety of complicated wounds located in several regions, particularly in the torso and extremities. To the best of our knowledge, the use of the VAC therapy in treating free flaps surgical wounds has not been discussed in the literature. Since 2009 at the Novara Major Hospital, we have been using the VAC therapy in selected cases for difficult and complicated wounds of the maxillofacial region. The purpose of this study is to describe and discuss three cases undergoing VAC therapy followed by loco-regional flaps in the management of exposed bone after fibular free flap. The advantages and disadvantages of VAC therapy in treating complicated wounds have been reported by several studies; compared with conventional wet-to-dry dressings, this system eliminates interstitial oedema, exudates and debrides while increasing blood perfusion leading to a more rapid promotion of wound healing with less bacterial loading. Although surgical debridement, wet-to-dry dressing changes and antibiotic treatment are the mainstay in managing maxillofacial wounds, VAC therapy can be used to obtain primary closure or to prepare the wound bed until definitive reconstruction is carried out. In our opinion, the VAC technique is an innovative therapy, and at our institution represents the standard of care for the majority of complicated wounds.
C1 [Benech, A.; Arcuri, F.; Poglio, G.; Brucoli, M.] Piemonte Orientale Univ, Maxillofacial Unit, Novara, Italy.
   [Guglielmetti, R.; Crespi, M. C.; Pia, F.] Piemonte Orientale Univ, Otorhinolaryngol Clin, Novara, Italy.
C3 University of Eastern Piedmont Amedeo Avogadro; University of Eastern
   Piedmont Amedeo Avogadro
RP Arcuri, F (通讯作者)，Osped Maggiore La Carita, SCDU Chirurg Maxillofacciale, Corso Mazzini 18, I-28100 Novara, Italy.
EM fraarcuri@libero.it
OI Poglio, Giuseppe/0000-0001-6867-048X; BRUCOLI,
   Matteo/0000-0002-2867-1936; BENECH, Arnaldo/0000-0003-1905-1089
CR Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Fabian TS, 2000, AM SURGEON, V66, P1136
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
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NR 21
TC 20
Z9 23
U1 0
U2 2
PU PACINI EDITORE
PI PISA
PA VIA DELLA GHERARDESCA-ZONA INDUSTRIALE OSPEDALETTO, 56121 PISA, ITALY
SN 0392-100X
EI 1827-675X
J9 ACTA OTORHINOLARYNGO
JI Acta Otorhinolaryngol. Ital.
PD JUN
PY 2012
VL 32
IS 3
BP 192
EP 197
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 967BQ
UT WOS:000305881500009
PM 22767986
DA 2026-07-24
ER
PT J
AU Anesäter, E
   Borgquist, O
   Torbrand, C
   Roupé, KM
   Ingemansson, R
   Lindstedt, S
   Malmsjö, M
AF Anesater, Erik
   Borgquist, Ola
   Torbrand, Christian
   Roupe, K. Markus
   Ingemansson, Richard
   Lindstedt, Sandra
   Malmsjo, Malin
TI The use of a rigid disc to protect exposed structures in wounds treated
   with negative pressure wound therapy: Effects on wound bed pressure and
   microvascular blood flow
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; EXPERIENCE;
   RUPTURE
AB There are increasing reports of deaths and serious complications associated with the use of negative pressure wound therapy (NPWT). Bleeding may occur in patients when NPWT is applied to a wound with exposed blood vessels or vascular grafts, possibly due to mechanical deformation and hypoperfusion of the vessel walls. Recent evidence suggests that using a rigid barrier disc to protect underlying tissue can prevent this mechanical deformation. The aim of this study was to examine the effect of rigid discs on the tissue exposed to negative pressure with regard to tissue pressure and microvascular blood flow. Peripheral wounds were created on the backs of eight pigs. The pressure and microvascular blood flow in the wound bed were measured when NPWT was applied. The wound was filled with foam, and rigid discs of different designs were inserted between the wound bed and the foam. The discs were created with or without channels (to accommodate exposed sensitive structures such as blood vessels and nerves), perforations, or a porous dressing that covered the underside of the discs (to facilitate pressure transduction and fluid evacuation). When comparing the results for pressure transduction to the wound bed, no significant differences were found using different discs covered with dressing, whereas pressure transduction was lower with bare discs. Microvascular blood flow in the wound bed decreased by 49?+/-?7% when NPWT was applied to control wounds. The reduction in blood flow was less in the presence of a protective disc (e.g., -6?+/-?5% for a dressing-covered, perforated disc, p?=?0.006). In conclusion, NPWT causes hypoperfusion of superficial tissue in the wound bed. The insertion of a rigid barrier counteracts this effect. The placement of a rigid disc over exposed blood vessels or nerves may protect these structures from rupture and damage.
C1 [Anesater, Erik; Borgquist, Ola; Torbrand, Christian; Roupe, K. Markus; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Anesater, Erik; Borgquist, Ola; Torbrand, Christian; Roupe, K. Markus; Ingemansson, Richard; Lindstedt, Sandra; Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
   [Borgquist, Ola] Lund Univ, Dept Anesthesiol, Lund, Sweden.
   [Torbrand, Christian] Lund Univ, Dept Urol, Lund, Sweden.
   [Ingemansson, Richard; Lindstedt, Sandra] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University; Lund University
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Torbrand, Christian/HIZ-8092-2022; Roupé, Markus/K-6502-2014; Lindstedt,
   Sandra/AEM-2892-2022; Borgquist, Ola/AAO-6451-2020
OI Torbrand, Christian/0000-0001-6442-7554; Roupé,
   Markus/0000-0001-5472-8134; Maljö, Malin/0000-0001-9849-9599;
   Ingemansson, Richard/0000-0001-7623-8953; Lindstedt,
   Sandra/0000-0003-4484-6473; 
FU Swedish Medical Research Council, Lund University Faculty of Medicine;
   Swedish Government Grant for Clinical Research, Lund University Hospital
   Research Grants; Swedish Medical Association; Royal Physiographic
   Society in Lund; Ake Wiberg Foundation; Anders Otto Sward
   Foundation/Ulrika Eklund Foundation; Magn Bergvall Foundation; Crafoord
   Foundation; Anna-Lisa and Sven-Erik Nilsson Foundation; Jeansson
   Foundation; Swedish Heart-Lung Foundation; Anna and Edvin Berger's
   Foundation; Marta Lundqvist Foundation; Lars Hierta Memorial Foundation
FX This study was supported by the Swedish Medical Research Council, Lund
   University Faculty of Medicine, the Swedish Government Grant for
   Clinical Research, Lund University Hospital Research Grants, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the Ake
   Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika Eklund
   Foundation, the Magn Bergvall Foundation, the Crafoord Foundation, the
   Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeansson Foundation, the
   Swedish Heart-Lung Foundation, Anna and Edvin Berger's Foundation, the
   Marta Lundqvist Foundation, and the Lars Hierta Memorial Foundation.
CR [Anonymous], PLAST RECONSTR SURG
   [Anonymous], S ADV WOUND CAR 2012
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   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P244, DOI 10.1111/j.1067-1927.2004.012117.x
NR 25
TC 10
Z9 12
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2012
VL 20
IS 4
BP 611
EP 616
DI 10.1111/j.1524-475X.2012.00801.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 967HA
UT WOS:000305896300019
PM 22672059
OA Bronze
DA 2026-07-24
ER
PT J
AU Fagerdahl, AM
   Boström, L
   Ulfvarson, J
   Ottosson, C
AF Fagerdahl, Ann-Mari
   Bostrom, Lennart
   Ulfvarson, Johanna
   Ottosson, Carin
TI Risk Factors for Unsuccessful Treatment and Complications With Negative
   Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB The aim of this retrospective study was to identify risk factors related to unsuccessful treatment and complications with negative pressure wound therapy (NPWT). Methods. A consecutive series of patients treated with NPWT for wounds of various etiologies (n = 87) from 2005-2007 at a general hospital in a large city (Stockholm, Sweden) were assessed for risk for unsuccessful treatment and complications associated with NPWT. Results. Twenty-nine percent of the patients treated with NPWT had unsuccessful treatment results. The strongest risk factors associated with unsuccessful treatment were pressure ulcers (OR 4.6) or a positive culture for Staphylococci (OR 3.4). The complication rate was 21%, of which 14 patients had to terminate treatment. A positive culture for either Staphylococci or Pseudomonas was strongly associated (P = 0.001) with risk of complications during NPWT treatment. Patients with insufficient peripheral circulation in the extremities had a risk of both unsuccessful treatment and complications. Conclusion. The findings of the present study stress the importance of evaluating bacterial cultures and adequate antibiotic therapy when infection is suspected. The status of the patient's peripheral macrocirculation in the lower extremities seems to have a significant impact on the risk of unsuccessful treatment or complications. There, fore, is it of great importance to evaluate peripheral circulation status before initializing NPWT.
C1 [Fagerdahl, Ann-Mari; Bostrom, Lennart; Ottosson, Carin] Karolinska Inst, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden.
   [Ulfvarson, Johanna] Karolinska Inst, Dept Neurobiol Care Sci & Soc, S-11883 Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet
RP Fagerdahl, AM (通讯作者)，Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.
EM ann-mari.fagerdahl@sodersjukhuset.se
OI Fagerdahl, Ami/0000-0002-9170-581X
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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NR 28
TC 15
Z9 17
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2012
VL 24
IS 6
BP 168
EP 177
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 971HT
UT WOS:000306195500006
PM 25874465
DA 2026-07-24
ER
PT J
AU Hardin, MO
   Mace, JE
   Ritchie, JD
   Chung, KK
   Markell, KW
   Renz, EM
   Wolf, SE
   Blackbourne, LH
   White, CE
AF Hardin, Mark O.
   Mace, James E.
   Ritchie, John D.
   Chung, Kevin K.
   Markell, Katharine W.
   Renz, Evan M.
   Wolf, Steven E.
   Blackbourne, Lorne H.
   White, Christopher E.
TI An Experience in the Management of the Open Abdomen in Severely Injured
   Burn Patients
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article; Proceedings Paper
CT 41st Annual Meeting of the American-Burn-Association
CY MAR 24-27, 2009
CL San Antonio, TX
SP Amer Burn Assoc
ID ABDOMINAL COMPARTMENT SYNDROME; OPERATION IRAQI FREEDOM; FASCIAL
   CLOSURE; TRAUMA PATIENTS
AB Few descriptions of temporary abdominal closure for planned relaparotomy have been reported in burned patients. The purpose of this study is to describe our experience and outcomes in the management of burned patients with an open abdomen. The authors performed a retrospective review of all admissions to our burn center from March 2003 to June 2008, identifying patients treated by laparotomy with temporary abdominal closure. The authors collected data on patient demographics, indication for laparotomy, methods of temporary and definitive abdominal closure, and outcomes. Of 2,104 patients admitted, 38 underwent a laparotomy with temporary abdominal closure. Their median TBSA was 55%, and the incidence of inhalation injury was 58%. Abdominal compartment syndrome was the most common indication for laparotomy (82%) followed by abdominal trauma (16%). The in-hospital mortality associated with an open abdomen was 68%. Temporary abdominal closure was performed most commonly using negative pressure wound therapy (90%). Fascial closure was performed in 21 patients but was associated with a 38% rate of failure requiring reexploration. Of 12 survivors, fascial closure was achieved in seven patients and five were managed with a planned ventral hernia. Burned patients who necessitate an open abdomen management strategy have a high morbidity and mortality. Fascial closure was associated with a high rate of failure but was successful in a select group of patients. Definitive abdominal closure with a planned ventral hernia was associated with no increased mortality and remains an option when "tension-free" fascial closure cannot be achieved. (J Burn Care Res 2012;33:491-496)
C1 [Hardin, Mark O.; Mace, James E.; Ritchie, John D.; Chung, Kevin K.; Markell, Katharine W.; Renz, Evan M.; Wolf, Steven E.; Blackbourne, Lorne H.; White, Christopher E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP White, CE (通讯作者)，USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
OI Wolf, Steven/0000-0003-2972-3440
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NR 21
TC 12
Z9 14
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2012
VL 33
IS 4
BP 491
EP 496
DI 10.1097/BCR.0b013e3182479b00
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Dermatology; Surgery
GA 972KC
UT WOS:000306275000016
PM 22777397
DA 2026-07-24
ER
PT J
AU Vig, S
   Dowsett, C
   Berg, L
   Caravaggi, C
   Rome, P
   Birke-Sorensen, H
   Bruhin, A
   Chariker, M
   Depoorter, M
   Dunn, R
   Duteille, F
   Ferreira, F
   Martínez, JMF
   Grudzien, G
   Hudson, D
   Ichioka, S
   Ingemansson, R
   Jeffery, S
   Krug, E
   Lee, C
   Malmsjo, M
   Runkel, N
   Martin, R
   Smith, J
AF Vig, S.
   Dowsett, C.
   Berg, L.
   Caravaggi, C.
   Rome, P.
   Birke-Sorensen, H.
   Bruhin, A.
   Chariker, M.
   Depoorter, M.
   Dunn, R.
   Duteille, F.
   Ferreira, F.
   Francos Martinez, J. M.
   Grudzien, G.
   Hudson, D.
   Ichioka, S.
   Ingemansson, R.
   Jeffery, S.
   Krug, E.
   Lee, C.
   Malmsjo, M.
   Runkel, N.
   Martin, R.
   Smith, J.
CA Int Expert Panel Negative Pressure
TI Evidence-based recommendations for the use of negative pressure wound
   therapy in chronic wounds: Steps towards an international consensus
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Review
DE Negative Pressure Wound Therapy (NPWT); Consensus; Recommendations;
   Systematic review; Chronic wounds; Pressure ulcers; Diabetic foot
   ulcers; Ischaemic ulcers
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; RANDOMIZED
   CONTROLLED-TRIAL; CHRONIC LEG ULCER; CLINICAL-APPLICATIONS; LIMB
   ISCHEMIA; SKIN-GRAFTS; AMPUTATION; MULTICENTER; EXPERIENCE
AB Aim: Negative Pressure Wound Therapy (NPWT) has become widely adopted over the last 15 years and over 1000 peer-reviewed publications are available describing its use. Despite this, there remains uncertainty regarding several aspects of usage. In order to respond to this gap a global expert panel was convened to develop evidence-based recommendations describing the use of NPWT. In this communication the results of the study of evidence in chronic wounds including pressure ulcers, diabetic foot ulcers (DFU), venous leg ulcers (VLU), and ischaemic lower limb wounds are reported.
   Methods: Evidence-based recommendations were obtained by a systematic review of the literature, grading of evidence, drafting of the recommendations by a global expert panel followed by a formal consultative consensus development program in which 422 independent healthcare professionals were able to agree or disagree with the recommendations. The criteria for agreement were set at 80% agreement. Evidence and recommendations were graded according to the SIGN (Scottish Intercollegiate Guidelines Network) classification system.
   Results: The primary treatment goal of NPWT in most chronic wounds is to achieve wound closure (either by secondary intention or preparing the wound for surgical closure). Secondary goals commonly include: to reduce wound dimensions, and to improve the quality of the wound bed. Thirteen evidence based recommendations were developed in total to address these treatment goals; 4 for pressure ulcers, 4 for DFU, 3 for ischaemic lower limb wounds and 2 for VLU.
   Conclusion: The present evidence base is strongest for the use of NPWT in non-ischaemic DFU and weakest in VLU. The development of evidence-based recommendations for NPWT with direct validation from a large group of practicing clinicians offers a broader basis for consensus than work by an expert panel alone. (c) 2011 Published by Elsevier Ltd on behalf of Tissue Viability Society.
C1 [Vig, S.] Croydon Univ Hosp, London, England.
   [Dowsett, C.] E London NHS Fdn Trust, Community Hlth Newham Directorate, London, England.
   [Berg, L.] Kuopio Univ Hosp, Kuopio, Finland.
   [Caravaggi, C.] Ctr Treatment Diabet Foot Pathol, Ist Clin Citta Studi, Milan, Italy.
   [Rome, P.] Royal Prince Alfred Hosp, Sydney, NSW, Australia.
   [Rome, P.] Concord Hosp, Sydney, NSW, Australia.
   [Birke-Sorensen, H.] Aleris Hamlet Hosp, Aarhus, Denmark.
   [Bruhin, A.] Dept Trauma & Visceral Surg, Luzern, Switzerland.
   [Chariker, M.] Aesthet Plast Surg Inst, Louisville, KY USA.
   [Depoorter, M.] Acad Hosp St Jan, Dept Plast & Reconstruct Surg, Brugge, Belgium.
   [Dunn, R.] Univ Massachusetts, Sch Med, Div Plast Surg, Worcester, MA USA.
   [Dunn, R.] Mem Hlth Care, Worcester, MA USA.
   [Duteille, F.] Hop Hotel Dieu, Aesthet & Reconstruct Surg Burn Unit, Nantes, France.
   [Ferreira, F.] Hosp Pedro Hispano, Matosinhos Porto, Portugal.
   [Francos Martinez, J. M.] Hosp Univ Bellvitge, Endocrine Surg Unit, Barcelona, Spain.
   [Grudzien, G.] John Paul 2 Hosp, Dept Cardiovasc Surg & Transplantol, Krakow, Poland.
   [Hudson, D.] Groote Schuur Hosp, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
   [Ichioka, S.] Saitama Med Univ, Dept Plast & Reconstruct Surg, Saitama, Japan.
   [Ingemansson, R.] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, Lund, Sweden.
   [Jeffery, S.] Queen Elizabeth Hosp, Royal Ctr Def Med, Birmingham B15 2TH, W Midlands, England.
   [Krug, E.] Leiden Univ, Med Ctr, NL-2300 RA Leiden, Netherlands.
   [Lee, C.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Lee, C.] St Marys Hosp, San Francisco, CA USA.
   [Malmsjo, M.] Skane Univ Hosp, Lund, Sweden.
   [Malmsjo, M.] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Runkel, N.] Univ Freiburg, Freiburg, Germany.
   [Runkel, N.] Black Forest Hosp, Dept Gen Surg, Villingen, Germany.
   [Martin, R.; Smith, J.] Smith & Nephew, Kingston Upon Hull, N Humberside, England.
C3 Croydon University Hospital; University of Eastern Finland; University
   of Eastern Finland Hospital; Kuopio University Hospital; NSW Health;
   Royal Prince Alfred Hospital; University of Sydney; Concord Repatriation
   General Hospital; University of Massachusetts System; University of
   Massachusetts Worcester; Nantes Universite; CHU de Nantes; Institut
   d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University
   Hospital; University of Barcelona; University of Cape Town; Saitama
   Medical University; Lund University; Skane University Hospital;
   University of Birmingham; Royal Centre for Defence Medicine; Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC); University of California System; University of California
   San Francisco; Lund University; Skane University Hospital; Lund
   University; University of Freiburg; Smith & Nephew
RP Runkel, N (通讯作者)，Postfach 2103, D-78011 Villingen Schwenningen, Germany.
EM norbert.runkel@sbk-vs.de
RI ; jeffery, steven/A-5207-2013; Birke-Sørensen, Hanne/B-6733-2015
OI Martin, Robin/0000-0002-9314-0437; Maljö, Malin/0000-0001-9849-9599;
   jeffery, steven/0000-0001-6587-5412; Ingemansson,
   Richard/0000-0001-7623-8953; 
FU SN
FX S&N provided funding for travel and accommodation for all face-to-face
   expert panel meetings, provided support regarding the published
   literature in NPWT, arranged and provided funding for the 'consultative
   phase' of the project (a symposium to 422 Healthcare professionals in
   Hamburg Feb 2010), provided support during the drafting of
   recommendations (authors Jenny Smith and Robin Martin) and provided
   medical writing services in preparation of this manuscript (author Jenny
   Smith). The recommendations reflect the independent and unbiased views
   of the panel and the consensus derived during the project and the
   content of the manuscript has not been unfairly influenced by Smith &
   Nephew.
CR [Anonymous], TASC 2 ALI DOC
   [Anonymous], TASC 2 PAD DOC
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], NPUAP REF
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NR 88
TC 83
Z9 102
U1 0
U2 47
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-206X
J9 J TISSUE VIABILITY
JI J. Viab.
PY 2011
VL 20
SU 1
BP S1
EP S18
DI 10.1016/j.jtv.2011.07.002
PG 18
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA 972UM
UT WOS:000306306000001
PM 22119531
DA 2026-07-24
ER
PT J
AU Anagnostakos, K
   Mosser, P
AF Anagnostakos, K.
   Mosser, P.
TI Bacteria identification on NPWT foams: clinical relevance or
   contamination?
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; bacteria growth; microbiological
   findings; bone infection
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; NEGATIVE-PRESSURE;
   BIOFILM FORMATION; STAPHYLOCOCCUS-AUREUS; GROWING BACTERIA; FOUNDATION;
   CANDIDA; STATE; MODEL
AB Objective: To compare and interpret the microbiological findings of tissue samples prior to and during negative pressure wound therapy (NPWT), as well as those of NPWT foams.
   Method: A retrospective evaluation of 101 NPWT dressings (29 polyurethane, 72 polyvinylalcohol; 43 deeply inserted, 56 superficially, two combined deeply and superficially; 67 hardware present and 34 no hardware present) in 64 patients was conducted. All foam and tissue samples were cultured over a period of 7 days. Tissue and foam samples were incubated on blood agar plates and in tryptic soya broth. Positive results indicated a microbial growth with > 10(5) colony forming units (CFU)/ml.
   Results: Total mean implantation period was 6 +/- 2 days (2-14 days). On 39 foams (39%), at least one organism could be identified. While S. aureus and S. epidermidis were the most common organisms prior to NPWT, during therapy S. epidermidis and S. aureus were most frequently identified in the tissue samples, with E. faecalis and S. epidermidis on the foams. In 12 cases (31%), the organisms in the tissue samples during NPWT and on the foams were identical, whereas in two cases a different organism was evident on the foam. In 6 cases (15%) the microbiological examination of the tissue samples was negative while positive on the foam. In the remaining 19 cases (54%), an organism could be identified on the foams while no tissue samples were microbiologically examined.
   Conclusion:This study shows that, in at least 20% of the cases, a bacterium might be solely identified on the NPWT foam or differ to those isolated in the tissue; whether this is a contamination, bacterial switch or the results of insufficient microbiological diagnostics prior to NPWT cannot be surely stated.
C1 [Anagnostakos, K.; Mosser, P.] Univ Hosp Saarland, Dept Orthopaed Surg, Saarland, Germany.
C3 Universitatsklinikum des Saarlandes
RP Anagnostakos, K (通讯作者)，Univ Hosp Saarland, Dept Orthopaed Surg, Saarland, Germany.
EM k.anagnostakos@web.de
RI Anagnostakos, Konstantinos/MGC-8753-2025
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NR 21
TC 14
Z9 16
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2012
VL 21
IS 7
BP 333
EP +
DI 10.12968/jowc.2012.21.7.333
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 973VJ
UT WOS:000306387600006
PM 22886333
DA 2026-07-24
ER
PT J
AU Glass, GE
   Nanchahal, J
AF Glass, Graeme E.
   Nanchahal, Jagdeep
TI The methodology of negative pressure wound therapy: Separating fact from
   fiction
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Negative pressure wound therapy; VAC; Wound filler; Interface material;
   Tissue perfusion
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; OF-THE-LITERATURE;
   RANDOMIZED CONTROLLED-TRIAL; CLINICAL-EXPERIENCE; CELL-PROLIFERATION;
   POLYURETHANE-FOAM; SEALING TECHNIQUE; MODEL; SKIN
AB Background: Negative pressure wound therapy (NPWT) is a technique that has gained such rapid acceptance for such a diversity of wound management problems that the evidence for optimal use has struggled to keep up. While clinical studies have sought to evaluate its effectiveness for a variety of acute and chronic wounds, preclinical studies have suggested that features such as the magnitude and periodicity of negative pressure, the wound filler and interface materials and the drainage conduit might introduce key pathophysiological variations at the wound bed influencing healing. Optimising the methodological approach is the key to achieving the best outcomes with NPWT. The aim of the present study was to evaluate and summarise the clinical and experimental evidence for how these methodological variations influence wound healing when using NPWT.
   Methods: A literature review was conducted to evaluate each component of NPWT inciting methodological variation with reference to clinical and preclinical variables including wound volume reduction, blood flow, granulation and growth factor stimulation.
   Results: Fourteen commercially available NPWT systems are currently available. Both foam and gauze transmit NP efficiently. While some preclinical evidence suggests foam may preferentially promote cell proliferation, there is no clear evidence to favour one wound filler. Most wound contraction occurs within the first -50 mmHg and physiological optimisation may be achieved within -80 mmHg. Cyclical NP-mediated cell mechanotransduction may alter the healing characteristics of the wound bed but no definitive clinical protocol has been established. There is insufficient evidence to credit NPWT with reduced bacterial wound colonisation.
   Conclusion: There is an urgent need to develop evidence-based NPWT regimes, tailoring the methodological aspects of therapy to the clinical need. An individualised strategy may yield improved outcomes and realise the potential of this powerful therapeutic intervention. (C) 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Glass, Graeme E.; Nanchahal, Jagdeep] Univ Oxford, Kennedy Inst Rheumatol, London W6 8LH, England.
C3 University of Oxford; Kennedy Institute for Rheumatology
RP Glass, GE (通讯作者)，Univ Oxford, Kennedy Inst Rheumatol, ARC Bldg,65 Aspenlea Rd, London W6 8LH, England.
EM graemeglass@hotmail.com
RI ; Glass, Graeme/I-7011-2019
OI Nanchahal, Jagdeep/0000-0002-9579-9411; 
FU Kennedy Institute of Rheumatology Trustees; Arthritis Research UK; NIHR
   Biomedical Research Centre
FX We are grateful for support from the Kennedy Institute of Rheumatology
   Trustees, Arthritis Research UK and the NIHR Biomedical Research Centre
   funding scheme.
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NR 81
TC 39
Z9 47
U1 0
U2 27
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2012
VL 65
IS 8
BP 989
EP 1001
DI 10.1016/j.bjps.2011.12.012
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 975CL
UT WOS:000306484300010
PM 22236476
DA 2026-07-24
ER
PT J
AU Semlacher, RA
   Taylor, EJ
   Golas, L
   Snyder, KR
   Semlacher, BM
   Martel, JR
   Martel, JB
AF Semlacher, Roy A.
   Taylor, Elise J.
   Golas, Liliya
   Snyder, Kiersten R.
   Semlacher, Berlin M.
   Martel, Joseph R.
   Martel, James B.
TI Safety of Negative-Pressure Wound Therapy Over Ocular Structures
SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; STATE
AB This is a report of the use, efficacy, and theoretic safety of negative-pressure wound therapy over ocular structures as a part of surgical treatment for necrotizing fasciitis. We treated a 65-year-old man with facial necrotizing fasciitis requiring serial debridement and closure of extensive periorbital and nasal wounds with skin grafts. Negative-pressure wound therapy was first used as a bridge to allow temporary closure and to encourage granulation tissue development. It was then used as a bolster dressing to stabilize skin grafts in the complex wound, not amenable to tie-over dressings. Excellent functional and cosmetic reconstruction of the periorbital and nasal regions was achieved. After treatment, the patient's corrected vision was 20/20. To our knowledge, the use of negative-pressure wound therapy directly over ocular structures has not been previously documented. In this case, it was safely used over the eyes with no sequelae to the patient's vision.
C1 [Taylor, Elise J.; Snyder, Kiersten R.; Semlacher, Berlin M.; Martel, Joseph R.; Martel, James B.] Martel Eye Med Grp, Rancho Cordova, CA 95670 USA.
   [Semlacher, Roy A.] Mercy San Juan Med Ctr, Carmichael, CA USA.
   [Golas, Liliya] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
C3 Stanford University
RP Martel, JR (通讯作者)，Martel Eye Med Grp, 11216 Trinity River Dr, Rancho Cordova, CA 95670 USA.
EM ojos@me.com
OI Snyder, Kiersten/0000-0003-2802-0524
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Byrnside V, 2010, J ORAL MAXIL SURG, V68, P935, DOI 10.1016/j.joms.2009.09.113
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NR 8
TC 5
Z9 5
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0740-9303
J9 OPHTHAL PLAST RECONS
JI Ophthalmic Plast. Reconstr. Surg.
PD JUL-AUG
PY 2012
VL 28
IS 4
BP E98
EP E101
DI 10.1097/IOP.0b013e318236859c
PG 5
WC Ophthalmology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology; Surgery
GA 977KE
UT WOS:000306657200012
PM 22186986
DA 2026-07-24
ER
PT J
AU Desai, KK
   Hahn, E
   Pulikkotill, B
   Lee, E
AF Desai, Kunj K.
   Hahn, Edward
   Pulikkotill, Benson
   Lee, Edward
TI Negative Pressure Wound Therapy: An Algorithm
SO CLINICS IN PLASTIC SURGERY
LA English
DT Article
DE Complications; Clinical evidence; Negative pressure wound therapy; NPWT;
   Subatmospheric pressure; Wound healing
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   ULCERS; SUBATMOSPHERIC PRESSURE; ABDOMINAL CLOSURE; FASCIAL CLOSURE;
   OPEN ABDOMEN; COST-EFFECTIVENESS; SUCTION DRAINAGE; CLINICAL-TRIAL
AB Negative pressure wound therapy (NPWT) has overwhelmed the wound-healing world. A systematic review puts it into perspective. The authors have developed an algorithm after careful evaluation and analysis of the scientific literature supporting the use of these devices. This article describes mechanisms of action, technical considerations, wound preparation, and clinical evidence, reviews the literature, and discusses NPWT use in specific wounds, such as diabetic foot ulcers, open abdomen, pressure ulcers, open fractures, sterna wounds, grafts, and flaps. Contraindications for and complications of NPWT are outlined, and specific recommendations given for the situations in which the authors use NPWT.
C1 [Lee, Edward] Univ Med & Dent New Jersey, New Jersey Med Sch, Div Plast Surg, Newark, NJ 07103 USA.
   [Desai, Kunj K.; Hahn, Edward; Pulikkotill, Benson] New Jersey Med Sch UMDNJ, Dept Surg, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences
RP Lee, E (通讯作者)，Univ Med & Dent New Jersey, New Jersey Med Sch, Div Plast Surg, 140 Bergen St,Suite E1620, Newark, NJ 07103 USA.
EM leee9@umdnj.edu
OI Lee, Edward/0000-0003-0487-3493
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NR 85
TC 31
Z9 34
U1 2
U2 34
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0094-1298
EI 1558-0504
J9 CLIN PLAST SURG
JI Clin. Plast. Surg.
PD JUL
PY 2012
VL 39
IS 3
BP 311
EP +
DI 10.1016/j.cps.2012.05.002
PG 15
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 980CN
UT WOS:000306871300009
PM 22732378
DA 2026-07-24
ER
PT J
AU Quyn, AJ
   Johnston, C
   Hall, D
   Chambers, A
   Arapova, N
   Ogston, S
   Amin, AI
AF Quyn, A. J.
   Johnston, C.
   Hall, D.
   Chambers, A.
   Arapova, N.
   Ogston, S.
   Amin, A. I.
TI The open abdomen and temporary abdominal closure systems - historical
   evolution and systematic review
SO COLORECTAL DISEASE
LA English
DT Review
DE Open abdomen; laparostomy; historical evolution; systematic review
ID VACUUM-ASSISTED CLOSURE; TRIAL COMPARING POLYGLACTIN-910-MESH; SEVERE
   INTRAABDOMINAL INFECTION; VASCULAR CATASTROPHES ABSENCE; TOPICAL
   NEGATIVE-PRESSURE; DAMAGE CONTROL LAPAROTOMY; CONTROL OPEN CELIOTOMIES;
   PRIMARY FASCIAL CLOSURE; CRITICALLY-ILL PATIENTS; PERITONEAL-CAVITY OPEN
AB Aim Several techniques for temporary abdominal closure have been developed. We systematically review the literature on temporary abdominal closure to ascertain whether the method can be tailored to the indication. Method Medline, Embase, the Cochrane Central Register of Controlled Trials and relevant meeting abstracts until December 2009 were searched using the following headings: open abdomen, laparostomy, VAC (vacuum assisted closure), TNP (topical negative pressure), fascial closure, temporary abdominal closure, fascial dehiscence and deep wound dehiscence. The data were analysed by closure technique and aetiology. The primary end-points included delayed fascial closure and in-hospital mortality. The secondary end-points were intra-abdominal complications. Results The search identified 106 papers for inclusion. The techniques described were VAC (38 series), mesh/sheet (30 series), packing (15 series), Wittmann patch (eight series), Bogota bag (six series), dynamic retention sutures (three series), zipper (15 series), skin only and locking device (one series each). The highest facial closure rates were seen with the Wittmann patch (78%), dynamic retention sutures (71%) and VAC (61%). Conclusion Temporary abdominal closure has evolved from simple packing to VAC based systems. In the absence of sepsis Wittmann patch and VAC offered the best outcome. In its presence VAC had the highest delayed primary closure and the lowest mortality rates. However, due to data heterogeneity only limited conclusions can be drawn from this analysis.
C1 [Quyn, A. J.; Johnston, C.; Hall, D.; Chambers, A.; Arapova, N.; Amin, A. I.] Fife NHS Trust, Victoria Hosp, Dept Gen Surg, Kirkcaldy KY2 5AH, Fife, Scotland.
   [Quyn, A. J.; Ogston, S.] Univ Dundee, Ninewells Hosp & Med Sch, Sch Med, Dundee DD1 9SY, Scotland.
C3 University of Dundee
RP Quyn, AJ (通讯作者)，Fife NHS Trust, Victoria Hosp, Dept Gen Surg, Hayfield Rd, Kirkcaldy KY2 5AH, Fife, Scotland.
EM aamin1@nhs.net
RI Johnston, Chris/ABC-5875-2020; Chambers, Adam Christian/HGU-5326-2022
OI Johnston, Chris/0000-0001-9935-7365; Quyn, Aaron/0000-0002-4333-5658;
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NR 126
TC 122
Z9 141
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD AUG
PY 2012
VL 14
IS 8
BP E429
EP E438
DI 10.1111/j.1463-1318.2012.03045.x
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 980NX
UT WOS:000306901200001
PM 22487141
DA 2026-07-24
ER
PT J
AU Chatzoulis, G
   Chatzoulis, K
   Spyridopoulos, P
   Pappas, P
   Ploumis, A
AF Chatzoulis, G.
   Chatzoulis, K.
   Spyridopoulos, P.
   Pappas, P.
   Ploumis, A.
TI Salvage of an infected titanium mesh in a large incisional ventral
   hernia using medicinal honey and vacuum-assisted closure: a case report
   and literature review
SO HERNIA
LA English
DT Review
DE Hernia repair; Infection; MRSA; Prosthetic mesh; Honey
ID REPAIR; COMPLICATIONS; PROPHYLAXIS; BACTERIA; EFFICACY; WOUNDS; TRIAL;
   MODEL
AB The overall reported percentage of mesh infections is 1.3%. Infections after incisional ventral hernia repair depend on many factors. Salvaging an infected mesh should be the priority, because serious complications are reported following mesh removal. In this case report, a methicillin-resistant Staphylococcus aureus (MRSA)-infected titanium mesh was salvaged by a novel technique, not requiring removal. The combination of vacuum-assisted closure (VAC (TM) therapy) of the wound and medical honey (L-Mesitran (TM)) proved to be successful in leaving the mesh in situ. We report the successful management of this infected titanium mesh and review the literature regarding the possible pathogenetic mechanisms and treatment options.
C1 [Chatzoulis, G.; Chatzoulis, K.; Spyridopoulos, P.; Pappas, P.] 424 Gen Mil Hosp, Dept Surg 1, Thessaloniki, Greece.
   [Ploumis, A.] Univ Ioannina, Dept Orthopaed & Rehabil, GR-45110 Ioannina, Greece.
C3 University of Ioannina
RP Chatzoulis, G (通讯作者)，424 Gen Mil Hosp, Dept Surg 1, Eukarpias Ave,VST 903, Thessaloniki, Greece.
EM surgchatz@yahoo.gr; kxatzo@yahoo.gr; pdsdoc@the.forthnet.gr;
   vasilaki@med.auth.gr; aploumis@cc.uoi.gr
OI Ploumis, Avraam/0000-0002-6828-3196
CR Anthony T, 2000, WORLD J SURG, V24, P95, DOI 10.1007/s002689910018
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   Stremitzer S, 2010, WORLD J SURG, V34, P1702, DOI 10.1007/s00268-010-0543-z
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NR 27
TC 13
Z9 14
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
J9 HERNIA
JI Hernia
PD AUG
PY 2012
VL 16
IS 4
BP 475
EP 479
DI 10.1007/s10029-010-0767-8
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 986IL
UT WOS:000307335200018
PM 21191626
DA 2026-07-24
ER
PT J
AU Dutton, M
   Curtis, K
AF Dutton, M.
   Curtis, K.
TI Well-wound therapy: use of NPWT to prevent laparotomy breakdown
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; prevention strategy; well-wound
   therapy; laparotomy breakdown
AB The use of negative pressure wound therapy (NPWT) for the treatment of wounds is not uncommon in modern health-care systems. However, use of NPWT as a wound prevention strategy, or 'well-wound therapy', is not so common. To date, papers that do discuss the use of NPWT in this way have focused mainly on orthopaedic and sternotomy wounds. This case study will present the use of NPWT with the goal of preventing laparotomy breakdown, utilising an innovative splinting technique.
C1 [Dutton, M.; Curtis, K.] St George Hosp, Trauma Serv, Sydney, NSW, Australia.
   [Dutton, M.; Curtis, K.] Univ Sydney, Sydney Nursing Sch, Sydney, NSW 2006, Australia.
   [Curtis, K.] George Inst Global Hlth, Sydney, NSW, Australia.
C3 St George Hospital; University of Sydney; George Institute for Global
   Health
RP Dutton, M (通讯作者)，St George Hosp, Trauma Serv, Sydney, NSW, Australia.
EM Matthew.Dutton@sesiahs.health.nsw.gov.au
RI ; Dutton, Matthew/PTF-9105-2026
OI Curtis, Kate/0000-0002-3746-0348; 
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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   Gomoll AH, 2006, J ORTHOP TRAUMA, V20, P705, DOI 10.1097/01.bot.0000211159.98239.d2
   Mangram AJ, 1999, INFECT CONT HOSP EP, V20, P250, DOI 10.1086/501620
   Pratin C, 2011, WOUND PRACT RES, V19, P122
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   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
   Willy C., 2006, The Theory and Practice of Vacuum Therapy: Scientific basis, Indications for use, case reports, practical advice
   Witham Gary, 2003, Nurs Times, V99, P30
NR 10
TC 4
Z9 5
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2012
VL 21
IS 8
BP 386
EP 388
DI 10.12968/jowc.2012.21.8.386
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 990EX
UT WOS:000307614900006
PM 22885311
DA 2026-07-24
ER
PT J
AU Ward, C
   Ciraulo, D
   Coulter, M
   Desjardins, S
   Liaw, L
   Peterson, S
AF Ward, Christopher
   Ciraulo, David
   Coulter, Michael
   Desjardins, Steven
   Liaw, Lucy
   Peterson, Sarah
TI Does treatment of split-thickness skin grafts with negative-pressure
   wound therapy improve tissue markers of wound healing in a porcine
   experimental model?
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; split thickness skin graft
ID VACUUM-ASSISTED CLOSURE; DEVICE; MIGRATION
AB BACKGROUND: Negative-pressure wound therapy (NPWT) has been used for to treat wounds for more than 15 years and, more recently, has been used to secure split-thickness skin grafts. There are some data to support this use of NPWT, but the actual mechanism by which NPWT speeds healing or improves skin graft take is not entirely known. The purpose of this project was to assess whether NPWT improved angiogenesis, wound healing, or graft survival when compared with traditional bolster dressings securing split-thickness skin grafts in a porcine model.
   METHODS: We performed two split-thickness skin grafts on each of eight 30 kg Yorkshire pigs. We took graft biopsies on postoperative days 2, 4, 6, 8, and 10 and submitted the samples for immunohistochemical staining, as well as standard hematoxylin and eosin staining. We measured the degree of vascular ingrowth via immunohistochemical staining for von Willenbrand's factor to better identify blood vessel epithelium. We determined the mean cross-sectional area of blood vessels present for each representative specimen, and then compared the bolster and NPWT samples. We also assessed each graft for incorporation and survival at postoperative day 10.
   RESULTS: Our analysis of the data revealed that there was no statistically significant difference in the degree of vascular ingrowth as measured by mean cross-sectional capillary area (p = 0.23). We did not note any difference in graft survival or apparent incorporation on a macroscopic level, although standard hematoxylin and eosin staining indicated that microscopically, there seemed to be better subjective graft incorporation in the NPWT samples and a nonsignificant trend toward improved graft survival in the NPWT group.
   CONCLUSION: We were unable to demonstrate a significant difference in vessel ingrowth when comparing NPWT and traditional bolster methods for split-thickness skin graft fixation. More studies are needed to elucidate the manner by which NPWT exerts its effects and the true clinical magnitude of these effects. (J Trauma Acute Care Surg. 2012;73: 447-451. Copyright (c) 2012 by Lippincott Williams & Wilkins)
C1 [Ward, Christopher; Ciraulo, David; Desjardins, Steven] Maine Med Ctr, Dept Surg, Portland, ME 04102 USA.
   [Liaw, Lucy; Peterson, Sarah] Maine Med Ctr, Res Inst, Scarborough, ME USA.
C3 Maine Medical Center; Maine Medical Center
RP Ward, C (通讯作者)，Maine Med Ctr, Dept Surg, 22 Bramhall St, Portland, ME 04102 USA.
EM wardc1@mmc.org
FU Maine Medical Center Mentored Research Committee; National Center for
   Research Resources at the National Institutes of Health [2P20RR018789,
   5P30 RR030927]
FX This study was supported with a grant from the Maine Medical Center
   Mentored Research Committee. This study also used materials provided
   free of cost by Smith and Nephew. There was no direct pharmaceutical or
   industry financial support.This study was conducted using existing
   resources funded by two grants, both from the National Center for
   Research Resources at the National Institutes of Health 2P20RR018789
   (PI: Wojchowski) and 5P30 RR030927 (PI: Friesel).
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NR 19
TC 6
Z9 6
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD AUG
PY 2012
VL 73
IS 2
BP 447
EP 450
DI 10.1097/TA.0b013e31825aa9ea
PG 4
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 992VG
UT WOS:000307807400039
PM 22846954
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Negosanti, L
   Sgarzani, R
   Nejad, P
   Pinto, V
   Tavaniello, B
   Palo, S
   Oranges, CM
   Fabbri, E
   Michelina, VV
   Zannetti, G
   Morselli, PG
   Cipriani, R
AF Negosanti, Luca
   Sgarzani, Rossella
   Nejad, Parissa
   Pinto, Valentina
   Tavaniello, Beatrice
   Palo, Stefano
   Oranges, Carlo Maria
   Fabbri, Erich
   Michelina, Veronica Vietti
   Zannetti, Guido
   Morselli, Paolo Giovanni
   Cipriani, Riccardo
TI VAC® therapy for wound management in patients with contraindications to
   surgical treatment
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE complex wound; topical negative pressure; VAC
ID VACUUM-ASSISTED CLOSURE; PRESSURE
AB The treatment of complex wounds often requires multiple surgical debridement and eventually reconstruction with skin grafts or flaps, under local or general anesthesia. When the patient's general conditions contraindicate surgical procedures, topical negative pressure with Vacuum Assisted Closure (VAC (R)) device can achieve wound healing with reduction of healing time and simpler management. We treated with VAC (R) device four patients with complex wounds and important contraindications to surgery. In all the patients, we used VAC (R) device with common protocol of topical negative pressure. The healing was obtained in a period variable between 18 and 40 days; the results were satisfactory in three cases, one patient developed an aesthetically unpleasant scar. We present our experience to propose VAC (R) when surgical procedures are contraindicated.
C1 [Negosanti, Luca; Sgarzani, Rossella; Nejad, Parissa; Pinto, Valentina; Tavaniello, Beatrice; Palo, Stefano; Oranges, Carlo Maria; Fabbri, Erich; Michelina, Veronica Vietti; Zannetti, Guido; Morselli, Paolo Giovanni; Cipriani, Riccardo] St Orsola Marcello Malpighi Hosp, Dept Plast Surg, I-40138 Bologna, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna
RP Negosanti, L (通讯作者)，St Orsola Marcello Malpighi Hosp, Dept Plast Surg, Via Massarenti 9, I-40138 Bologna, Italy.
EM luca.negosanti81@gmail.com
RI Oranges, Carlo M/ABI-2156-2020; Negosanti, Luca/AAF-1605-2020; Sgarzani,
   Rossella/M-7495-2018
OI Oranges, Carlo M/0000-0003-1735-5329; Negosanti,
   Luca/0000-0002-8110-3604; FABBRI, ERICH/0000-0002-3808-3185; Sgarzani,
   Rossella/0000-0002-5543-8013
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Giovannini UM, 2001, WOUNDS, V13, P82
   Heugel JR, 2002, J BURN CARE REHABIL, V23, P167, DOI 10.1097/00004630-200205000-00005
   McCord SS, 2007, WOUND REPAIR REGEN, V15, P296, DOI 10.1111/j.1524-475X.2007.00229.x
   Morykwas M J, 1997, J South Orthop Assoc, V6, P279
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Negosanti L, 2010, EUR J DERMATOL, V20, P501, DOI 10.1684/ejd.2010.0964
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Thompson JT, 2007, CLIN PLAST SURG, V34, P673, DOI 10.1016/j.cps.2007.07.005
   Whitworth, 2004, 1 INT TOP NEG PRESS, P22
   Wild T, 2007, Ther Umsch, V64, P495, DOI 10.1024/0040-5930.64.9.495
NR 14
TC 6
Z9 6
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD MAY-JUN
PY 2012
VL 25
IS 3
SI SI
BP 277
EP 280
DI 10.1111/j.1529-8019.2012.01451.x
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 993TH
UT WOS:000307882000010
PM 22913447
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Tuncel, U
   Turan, A
   Bayraktar, MA
   Aydin, U
   Erkorkmaz, U
AF Tuncel, Umut
   Turan, Aydin
   Bayraktar, M. Alper
   Aydin, Ufuk
   Erkorkmaz, Unal
TI Clinical Experience With the Use of Gauze-based Negative Pressure Wound
   Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TRANSDUCTION; MANAGEMENT; INJURIES; PATIENT;
   IMPACT; FOAM
AB Purpose. In this preliminary study, gauze-based negative pressure wound therapy (NPWT) was used to accelerate granulation tissue formation and promote closure in a number of wound types. The authors aimed to evaluate the efficacy of gauze-based NPWT using the Chariker-Jeter technique for wounds requiring delayed closure. Methods. A retrospective review was conducted of 50 patients with wounds not suitable for immediate primary closure. After initial irrigation, debridement, and antibiotic therapy, Chariker-Jeter technique NPWT was used and dressings were changed at 24- to 48-hour intervals before secondary closure or primary closure. In addition, a 4-point category scoring system (severe, moderate, mild, and none) was used to evaluate pain. Semi-quantitative data also were obtained. Results. Wound size decreased considerably, granulation tissue formation was accelerated, and exudate was reduced and removed by the end of the treatment. The patients were followed for 12 months. Pre- and post-treatment averages of the wound surface areas were 90.21 +/- 74.97 cm(2) and 35.71 +/- 53.63 cm(2), respectively (P < 0.001). Average duration of treatment was 12.98 +/- 3.18 days and average wound size reduction following the treatment was 64.61% +/- 30.42%. Granulation tissue was clinically observed in all wounds by day 5. Six cases healed without any operation; the others required various reconstructive methods to cover the wounds. After surgical intervention, only 3 patients treated with gauze-based NPWT had a recurrence. No infections were observed during the follow-up period. According to the pain form, only 2 patients had severe pain. Conclusion. The gauze-based NPWT was found to be a safe and cost-effective method in temporary soft-tissue management of chronic nonhealing wounds suitable delayed closure.
C1 [Tuncel, Umut] Gaziosmanpasa Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, TR-60100 Tokat, Turkey.
   [Bayraktar, M. Alper] Cekirge State Hosp, Dept Plast Reconstruct & Aesthet Surg, Bursa, Turkey.
   [Aydin, Ufuk] Edirne State Hosp, Dept Plast Reconstruct & Aesthet Surg, Edirne, Turkey.
   [Erkorkmaz, Unal] Gaziosmanpasa Univ, Dept Biostat, TR-60100 Tokat, Turkey.
C3 Tokat Gaziosmanpasa University; Cekirge State Hospital; Edirne State
   Hospital; Tokat Gaziosmanpasa University
RP Tuncel, U (通讯作者)，Gaziosmanpasa Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, TR-60100 Tokat, Turkey.
EM drumuttuncel@gmail.com
RI Turan, Aydın/V-6669-2017; Tuncel, Umut/P-3185-2015; Erkorkmaz,
   Ünal/AAA-4241-2022
OI Turan, Aydın/0000-0002-1540-1443; Tuncel, Umut/0000-0001-5029-2927;
   Erkorkmaz, Ünal/0000-0002-8497-4704
CR Abai B, 2007, J VASC SURG, V45, P610, DOI 10.1016/j.jvs.2006.10.043
   Ashcroft GS, 2003, AM J CLIN DERMATOL, V4, P737, DOI 10.2165/00128071-200304110-00002
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Bollero D, 2007, WOUND REPAIR REGEN, V15, P589, DOI 10.1111/j.1524-475X.2007.00267.x
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
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   CHARIKER M E, 1989, Contemporary Surgery, V34, P59
   Chariker ME, 2009, PLAST RECONSTR SURG, V123, P1510, DOI 10.1097/PRS.0b013e3181a20563
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   de Lange MY, 2000, EUR J PLAST SURG, V23, P178, DOI 10.1007/s002380050244
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   DeFranzo AJ, 1999, PLAST RECONSTR SURG, V104, P2145, DOI 10.1097/00006534-199912000-00031
   Dunn RM, 2011, EPLASTY, V16, P11
   Franczyk M, 2009, PLAST RECONSTR SURG, V124, P854, DOI 10.1097/PRS.0b013e3181b038b4
   Gilliver SC, 2007, CLIN DERMATOL, V25, P56, DOI 10.1016/j.clindermatol.2006.09.012
   Herscovici D, 2003, J ORTHOP TRAUMA, V17, P683, DOI 10.1097/00005131-200311000-00004
   Hurd T, 2010, INT WOUND J, V7, P448, DOI 10.1111/j.1742-481X.2010.00714.x
   Krasner Diane L, 2002, Ostomy Wound Manage, V48, P38
   Malmsjö M, 2010, INT WOUND J, V7, P406, DOI 10.1111/j.1742-481X.2010.00706.x
   Malmsjö M, 2009, WOUND REPAIR REGEN, V17, P200, DOI 10.1111/j.1524-475X.2009.00461.x
   Psoinos CM, 2009, J PEDIATR SURG, V44, pE23, DOI 10.1016/j.jpedsurg.2009.09.022
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
NR 23
TC 1
Z9 1
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2012
VL 24
IS 8
BP 227
EP 233
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 994EI
UT WOS:000307913300010
PM 25874610
DA 2026-07-24
ER
PT J
AU Stoffan, AP
   Ricca, R
   Lien, C
   Quigley, S
   Linden, BC
AF Stoffan, Alexander P.
   Ricca, Robert
   Lien, Chueh
   Quigley, Sandy
   Linden, Bradley C.
TI Use of negative pressure wound therapy for abdominal wounds in neonates
   and infants
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Neonatal; Infant; Abdominal wounds; Negative pressure wound therapy;
   Surgery
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; MANAGEMENT; TRAUMA; EXPERIENCE;
   CHILDREN
AB Background: Negative pressure wound therapy (NPWT) is an established and effective tool in the management of complicated abdominal wounds. This management approach has been used in infants, but few large series reports exist in the literature.
   Methods: The outcomes of infants with abdominal wounds receiving NPWT over the last 10 years at our institution were evaluated. Overall survival, time between initiation of NPWT, and discharge/death were examined.
   Results: We identified 18 infants who had abdominal wounds treated with NPWT. Diagnoses were varied, as was the duration of therapy. The median NPWT duration of treatment was 34.0 +/- 92.1 days. Forty-four percent of the infants had a stoma before application of NPWT, and 22% of the infants had enterocutaneous fistulas before use of NPWT. There were only 2 cases in which a new fistula developed during the use of NPWT, and both of these omphalopagus conjoined twins had undergone the Bianchi procedure. No additional NPWT-related complications were identified. Of 18 infants, 6 died in this cohort.
   Conclusion: Negative pressure wound therapy is an important therapeutic tool for the management of abdominal wounds in infants. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Stoffan, Alexander P.; Lien, Chueh; Linden, Bradley C.] Harvard Univ, Sch Med, Dept Surg, Childrens Hosp Boston, Boston, MA 02115 USA.
   [Ricca, Robert] Univ Washington, Sch Med, Seattle Childrens Hosp, Dept Pediat Surg, Seattle, WA 98105 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Boston Children's Hospital; University of Washington;
   University of Washington Seattle; Seattle Children's Hospital
RP Stoffan, AP (通讯作者)，Harvard Univ, Sch Med, Dept Surg, Childrens Hosp Boston, Boston, MA 02115 USA.
EM bradley.linden@childrens.harvard.edu
CR [Anonymous], 2007, OPUS 12 SCI
   Baharestani MM, 2007, OSTOMY WOUND MANAG, V53, P75
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   CHARIKER M E, 1989, Contemporary Surgery, V34, P59
   Chariker ME, 2009, PLAST RECONSTR SURG, V123, P1510, DOI 10.1097/PRS.0b013e3181a20563
   Costa AD., 2006, ANZ J SURG, V76, P356
   DeFranzo AJ, 2008, PLAST RECONSTR SURG, V121, P832, DOI 10.1097/01.prs.0000299268.51008.47
   Fenton SJ, 2007, J PEDIATR SURG, V42, P957, DOI 10.1016/j.jpedsurg.2007.01.029
   Garner GB, 2001, AM J SURG, V182, P630, DOI 10.1016/S0002-9610(01)00786-3
   Lopez G, 2008, J PEDIATR SURG, V43, P2202, DOI 10.1016/j.jpedsurg.2008.08.067
   Malmsjö M, 2009, ANN PLAS SURG, V63, P676, DOI 10.1097/SAP.0b013e31819ae01b
   McCord SS, 2007, WOUND REPAIR REGEN, V15, P296, DOI 10.1111/j.1524-475X.2007.00229.x
   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
   Morris GS, 2007, OSTOMY WOUND MANAG, V53, P52
   Pauniaho SL, 2009, J PEDIATR SURG, V44, P1736, DOI 10.1016/j.jpedsurg.2009.01.009
   Pham C T, 2006, J Wound Care, V15, P240
   Prichayudh S, 2011, SURG TODAY, V41, P72, DOI 10.1007/s00595-009-4202-7
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   Thompson JT, 2007, CLIN PLAST SURG, V34, P673, DOI 10.1016/j.cps.2007.07.005
   Zupancic JAF, 2007, PEDIATRICS, V119, pE156, DOI 10.1542/peds.2005-2957
NR 21
TC 19
Z9 21
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD AUG
PY 2012
VL 47
IS 8
BP 1555
EP 1559
DI 10.1016/j.jpedsurg.2012.01.014
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 995HY
UT WOS:000308000100022
PM 22901916
DA 2026-07-24
ER
PT J
AU Berger, P
   de Bie, D
   Moll, FL
   de Borst, GJ
AF Berger, Paul
   de Bie, Dennis
   Moll, Frans L.
   de Borst, Gert-Jan
TI Negative pressure wound therapy on exposed prosthetic vascular grafts in
   the groin
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID VACUUM ASSISTED CLOSURE; INFECTIONS; MANAGEMENT; FLAPS
AB Objective: This study assessed the outcome of vacuum-assisted closure (VAC) as primary therapy for exposed prosthetic vascular grafts in the groin (Szilagyi III).
   Methods: The study included all consecutive patients with Szilagyi III groin infections and exposed prosthetic graft material from 2009 to 2011. After initial wound debridement, VAC was applied using a two-layer combination, consisting of polyvinyl alcohol and polyurethane sponges. Continuous negative pressure was set on a maximum of 50 mm Hg. All patients received complementary antibiotic therapy. The primary end point was defined as complete wound closure. Secondary end points comprised bleeding complications, amputation, and death.
   Results: The study evaluated 15 patients with 17 Szilagyi III groin infections. Mean total length of VAC therapy was 43 days (range, 14-76 days). Mean time until complete healing was 51 days (range, 24-82 days). Mean length of VAC therapy in the hospital was 21 days (range, 5-61 days). Eleven patients received continued VAC treatment at home for a mean length of 22 days (range, 5-69 days). Complete healing was achieved in 14 groins (82%). Three failures due to persisting infection, persisting necrosis, and a pseudomonas infection were noted. No bleeding complications, amputations, or late reinfections occurred. Median follow-up was 380 days (range, 56-939 days). Despite therapy failure, all 17 grafts were preserved.
   Conclusions: VAC therapy on an exposed prosthetic vascular graft in the groin is safe and feasible when applying a combination of polyvinyl alcohol and polyurethane foam dressing and 50 mm Hg of continuous negative pressure, resulting in midterm graft preservation. (J Vasc Surg 2012;56:714-20.)
C1 [Berger, Paul; de Bie, Dennis; Moll, Frans L.; de Borst, Gert-Jan] Univ Med Ctr Utrecht, Dept Vasc Surg, NL-3508 GA Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center
RP Berger, P (通讯作者)，Univ Med Ctr Utrecht, Dept Vasc Surg, G04-129,POB 85500, NL-3508 GA Utrecht, Netherlands.
EM p.berger@umcutrecht.nl
CR Colwell AS, 2004, ANN PLAS SURG, V52, P49, DOI 10.1097/01.sap.0000099960.68038.53
   Dosluoglu HH, 2010, J VASC SURG, V51, P1160, DOI 10.1016/j.jvs.2009.11.053
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   Kotsis T, 2007, ACTA CHIR BELG, V107, P37, DOI 10.1080/00015458.2007.11680008
   Mayer D, 2011, ANN SURG, V254, P754, DOI 10.1097/SLA.0b013e3182365864
   O'Connor S, 2006, J VASC SURG, V44, P38, DOI 10.1016/j.jvs.2006.02.053
   Perera Ganesha B, 2006, Vasc Endovascular Surg, V40, P1, DOI 10.1177/153857440604000101
   PERLER BA, 1993, J VASC SURG, V18, P358, DOI 10.1016/0741-5214(93)90252-H
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NR 18
TC 26
Z9 31
U1 0
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD SEP
PY 2012
VL 56
IS 3
BP 714
EP 720
DI 10.1016/j.jvs.2012.02.007
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 996KM
UT WOS:000308085500018
PM 22554424
DA 2026-07-24
ER
PT J
AU Polzer, H
   Mutschler, W
AF Polzer, H.
   Mutschler, W.
TI Vacuum assisted closure therapy. Management of a severe blast injury to
   the lower limb
SO UNFALLCHIRURG
LA German
DT Article
DE Blast injury; Lower extremity; Negative pressure wound therapy; Soft
   tissue injury; Wound management
ID SOFT-TISSUE INJURY; OPEN FRACTURES; NEGATIVE-PRESSURE; WOUND CONTROL
AB This article reports the case of a 23-year-old woman who sustained severe soft tissue injuries with open fractures of the left distal femur, the left proximal tibia, a subtotal amputation of the left foot with injuries to the anterior and posterior tibial artery due to a bomb blast. When the patient was transferred to our hospital 17 days after the trauma, all primarily closed wounds were severely infected. The fractures were treated by external fixateur and k-wire fixation. After debridement and initiation of negative pressure therapy the anterior tibial artery was reconstructed after 3 days and partial wound closure by a rectus abdominis muscle flap was achieved after 19 days. After almost total wound closure was accomplished open reduction internal fixation (ORIF) was performed for the distal femur fracture and a modification of the external fixateur for the tibial and foot fractures. The negative pressure therapy is an important component for treatment of complex soft tissue injuries and open fractures; however, it must be embedded in an interdisciplinary treatment plan with well-defined treatment goals.
C1 [Polzer, H.; Mutschler, W.] Klinikum Ludwig Maximilians Univ Munchen, Chirurg Klin & Poliklin, D-80336 Munich, Germany.
C3 University of Munich
RP Polzer, H (通讯作者)，Klinikum Ludwig Maximilians Univ Munchen, Chirurg Klin & Poliklin, Campus Innenstadt,Nussbaumstr 20, D-80336 Munich, Germany.
EM hans.polzer@med.uni-muenchen.de
RI Polzer, Hans/Q-3864-2019
OI Polzer, Hans/0000-0002-6713-4017
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Evans D, 2001, BRIT J PLAST SURG, V54, P238, DOI 10.1054/bjps.2001.3547
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   GUSTILO RB, 1976, J BONE JOINT SURG AM, V58, P453, DOI 10.2106/00004623-197658040-00004
   Holle G, 2007, UNFALLCHIRURG, V110, P490, DOI 10.1007/s00113-007-1267-x
   Holle G, 2007, UNFALLCHIRURG, V110, P289, DOI 10.1007/s00113-007-1265-z
   Kamolz LP, 2004, BURNS, V30, P253, DOI 10.1016/j.burns.2003.12.003
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
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   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
NR 11
TC 1
Z9 1
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
J9 UNFALLCHIRURG
JI Unfallchirurg
PD SEP
PY 2012
VL 115
IS 9
BP 792
EP 797
DI 10.1007/s00113-012-2210-3
PG 6
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 998JV
UT WOS:000308235200008
PM 22935897
DA 2026-07-24
ER
PT J
AU Losi, P
   Briganti, E
   Costa, M
   Sanguinetti, E
   Soldani, G
AF Losi, Paola
   Briganti, Enrica
   Costa, Manolo
   Sanguinetti, Elena
   Soldani, Giorgio
TI Silicone-coated non-woven polyester dressing enhances
   reepithelialisation in a sheep model of dermal wounds
SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; THERAPY; EVOLUTION
AB Negative-pressure wound therapy (NPWT) also known as V.A.C. (Vacuum-assisted closure), is widely used to manage various type of wounds and accelerate healing. NPWT has so far been delivered mainly via open-cell polyurethane (PU) foam or medical gauze. In this study an experimental setup of sheep wound model was used to evaluate, under NPWT conditions, the performance of a silicone-coated non-woven polyester (N-WPE) compared with PU foam and cotton hydrophilic gauze, used as reference materials. Animals were anesthetized with spontaneous breathing to create three 3 x 3 cm skin defects bilaterally; each animal received three different samples on each side (n = 6 in each experimental group) and was subjected to negative and continuous 125 mmHg pressure up to 16 days. Wound conditions after 1, 8 and 16 days of treatment with the wound dressings were evaluated based on gross and histological appearances. Skin defects treated with the silicone-coated N-WPE showed a significant decrease in wound size, an increase of re-epithelialization, collagen deposition and wound neovascularisation, and a minimal stickiness to the wound tissue, in comparison with gauze and PU foam. Taken all together these findings indicate that the silicone-coated N-WPE dressing enhances wound healing since stimulates higher granulation tissue formation and causes minor tissue trauma during dressing changes.
C1 [Losi, Paola; Briganti, Enrica; Costa, Manolo; Sanguinetti, Elena; Soldani, Giorgio] CNR, Lab Biomat & Graft Technol, Inst Clin Physiol, I-54100 Massa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR)
RP Soldani, G (通讯作者)，CNR, Lab Biomat & Graft Technol, Inst Clin Physiol, Via Aurelia Sud, I-54100 Massa, Italy.
EM giorgio.soldani@ifc.cnr.it
OI Soldani, Giorgio/0000-0002-9042-0994; Losi, Paola/0000-0002-1350-8626
CR [Anonymous], WOUNDS LACERATIONS E
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Banwell Paul, 2006, J Tissue Viability, V16, P16
   Bassetto F, 2012, J PLAST RECONSTR AES, V65, P91, DOI 10.1016/j.bjps.2011.08.016
   Bollero D, 2010, OSTOMY WOUND MANAG, P4
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   CHARIKER M E, 1989, Contemporary Surgery, V34, P59
   Davies P., 2008, J WOUND CARE S, V17, P1
   DeWall RA, 2003, ANN THORAC SURG, V76, pS2210, DOI 10.1016/j.athoracsur.2003.09.007
   Edwards Jacky, 2009, Br J Community Nurs, V14, pS32
   Falanga V, 2005, LANCET, V366, P1736, DOI 10.1016/S0140-6736(05)67700-8
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   Morris Clare, 2009, Paediatr Nurs, V21, P38
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   Mouës CM, 2007, J PLAST RECONSTR AES, V60, P672, DOI 10.1016/j.bjps.2006.01.041
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Petzina R, 2007, J THORAC CARDIOV SUR, V133, P1154, DOI 10.1016/j.jtcvs.2007.01.011
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   WUWHS, 2008, VAC ASS CLOS REC US
NR 28
TC 8
Z9 10
U1 0
U2 28
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-4530
EI 1573-4838
J9 J MATER SCI-MATER M
JI J. Mater. Sci.-Mater. Med.
PD SEP
PY 2012
VL 23
IS 9
BP 2235
EP 2243
DI 10.1007/s10856-012-4701-8
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 998LY
UT WOS:000308242000019
PM 22692367
OA gold
DA 2026-07-24
ER
PT J
AU Blum, ML
   Esser, M
   Richardson, M
   Paul, E
   Rosenfeldt, FL
AF Blum, Martin L.
   Esser, Max
   Richardson, Martin
   Paul, Eldho
   Rosenfeldt, Franklin L.
TI Negative Pressure Wound Therapy Reduces Deep Infection Rate in Open
   Tibial Fractures
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy; open fractures; open tibial fractures;
   deep infection
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; LOWER-EXTREMITY TRAUMA;
   SHAFT FRACTURES; INTRAMEDULLARY NAILS; TEMPORARY TREATMENT;
   RANDOMIZED-TRIAL; MANAGEMENT; COMPLICATIONS; NONUNION
AB Objectives: To evaluate the effect of negative pressure wound therapy (NPWT) on deep infection rate in open tibial fractures.
   Design: Retrospective cohort study. Data was collected from medical records and radiographs.
   Setting: Two level-1 trauma centers.
   Patients/Participants: Patients who sustained an open tibial fracture which underwent delayed soft tissue coverage between January 2002 and December 2007 were included. Exclusion criteria included open fractures receiving a combination of NPWT and conventional dressings, fractures which were treated with a primary amputation, and fractures associated with mortality.
   Intervention: NPWT with reticulated open cell foam or conventional dressings at surgeon's discretion.
   Main Outcome Measurement: Deep infection rate.
   Results: A total of 229 open tibial fractures in 220 patients met the inclusion criteria and received either NPWT (166/229-72%) or conventional dressings (63/229-28%). There was a decreased rate of deep infection in the NPWT group compared with the conventional dressing group [8.4% (14/166) vs. 20.6%(13/63); P = 0.01]. Univariate predictors of deep infection included Gustilo type {odds ratio (OR): 3.13 [95% confidence interval (CI): 1.74-5.64]; P, 0.001} and use of NPWT [OR: 0.35 (95% CI: 0.16-0.80); P = 0.01]. When adjustment was performed for Gustilo type with multivariate analysis, use of NPWT was found to reduce the risk of deep infection by almost 80% [OR: 0.22 (95% CI: 0.09-0.55); P = 0.001].
   Conclusions: These results suggest that NPWT reduces the rate of deep infection when used for the dressing of traumatic wounds in open tibial fractures.
C1 [Blum, Martin L.; Rosenfeldt, Franklin L.] Monash Univ, Fac Med Nursing & Hlth Sci, Melbourne, Vic 3004, Australia.
   [Blum, Martin L.] NTRI, Melbourne, Vic, Australia.
   [Blum, Martin L.; Rosenfeldt, Franklin L.] Alfred Hosp, Dept Surg, Melbourne, Vic, Australia.
   [Esser, Max] Alfred Hosp, Dept Orthopaed Surg, Melbourne, Vic, Australia.
   [Richardson, Martin] Royal Melbourne Hosp, Dept Orthopaed Surg, Melbourne, Vic, Australia.
   [Paul, Eldho] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia.
C3 Monash University; Florey Institute of Neuroscience & Mental Health;
   Howard Florey Institute Affiliates; Florey Institute of Neuroscience &
   Mental Health; Howard Florey Institute Affiliates; Melbourne Health;
   Royal Melbourne Hospital; Monash University
RP Blum, ML (通讯作者)，23-185 Barkly St, St Kilda, Vic 3182, Australia.
EM martyblum@hotmail.com
RI ; Richardson, Martin/H-2272-2018
OI Paul, Eldho/0000-0003-1263-7255; 
CR Alberts KA, 1999, INJURY, V30, P519, DOI 10.1016/S0020-1383(99)00143-6
   [Anonymous], 2007, J ORTHOP TRAUMA S10, V21, pS1
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NR 38
TC 80
Z9 94
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2012
VL 26
IS 9
BP 499
EP 505
DI 10.1097/BOT.0b013e31824133e3
PG 7
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 999YQ
UT WOS:000308352200014
PM 22487900
DA 2026-07-24
ER
PT J
AU Large, TM
   Douglas, G
   Erickson, G
   Grayson, JK
AF Large, Thomas M.
   Douglas, Geoffrey
   Erickson, Gregory
   Grayson, J. Kevin
TI Effect of Negative Pressure Wound Therapy on the Elution of Antibiotics
   From Polymethylmethacrylate Beads in a Porcine Simulated Open Femur
   Fracture Model
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy; bone cement; anti-bacterial agents;
   tobramycin; vancomycin
ID VACUUM-ASSISTED CLOSURE; ACRYLIC BONE-CEMENT; OPEN CELL FOAM;
   SOFT-TISSUE INJURIES; SPACERS IN-VIVO; 2-STAGE REVISION; HIP SPACERS;
   VANCOMYCIN; GENTAMICIN; TOBRAMYCIN
AB Objectives: To determine whether negative pressure wound therapy (NPWT) affects antibiotic elution in simulated femur fractures treated with antibiotic impregnated polymethylmethacrylate (PMMA) beads and whether fascial closure between beads and sponge affects the outcome.
   Methods: PMMA beads containing vancomycin and tobramycin were placed adjacent to bilateral corticotomies created in 20 anesthetized pigs. In 1 leg, NPWT was applied with the sponge either in direct contact with the beads or superficial to reapproximated fascia lata. The contralateral wound was conventionally closed. Vancomycin and tobramycin concentrations in wound drainage were measured every 12 hours for 72 hours, and tobramycin levels were measured in periosteal tissue obtained at 72 hours.
   Results: Drainage vancomycin and tobramycin concentrations were highest at 12 hours and fell rapidly by 24 hours but remained steady thereafter. At each 12-hour interval, there were no significant differences in the vancomycin and tobramycin concentrations between NPWT and control wound drainage, although whether the fascia was closed or left open had an influence on vancomycin levels. The total vancomycin and tobramycin eluted into the drains was significantly less in the NPWT group with open fascia. The antibiotic levels measured in wound drainage remained above the minimum inhibitory concentration for common wound organisms throughout the study period. Neither NPWT nor fascial closure had a significant effect on tobramycin periosteal tissue concentrations.
   Conclusions: Concurrent application of NPWT with antibiotic impregnated PMMA beads to simulated open femur fractures in pigs did not decrease local antibiotic concentrations but did decrease the total amount of eluted vancomycin and tobramycin locally available when the fascia was left open.
C1 [Large, Thomas M.; Erickson, Gregory] David Grant USAF Med Ctr, Dept Orthopaed Surg, Bodin Circle Travis AFB, CA 94535 USA.
   [Douglas, Geoffrey; Grayson, J. Kevin] David Grant USAF Med Ctr, Clin Invest Facil, Bodin Circle Travis AFB, CA 94535 USA.
RP Large, TM (通讯作者)，David Grant USAF Med Ctr, Dept Orthopaed Surg, 101 Bodin Circle Travis AFB, Bodin Circle Travis AFB, CA 94535 USA.
EM tom_large@hotmail.com
OI Large, Thomas/0000-0002-7087-0031
CR ADAMS K, 1992, CLIN ORTHOP RELAT R, P244
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NR 39
TC 9
Z9 14
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2012
VL 26
IS 9
BP 506
EP 511
DI 10.1097/BOT.0b013e31825354ce
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 999YQ
UT WOS:000308352200015
PM 22549033
DA 2026-07-24
ER
PT J
AU Stinner, DJ
   Hsu, JR
   Wenke, JC
AF Stinner, Daniel J.
   Hsu, Joseph R.
   Wenke, Joseph C.
TI Negative Pressure Wound Therapy Reduces the Effectiveness of Traditional
   Local Antibiotic Depot in a Large Complex Musculoskeletal Wound Animal
   Model
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE Negative pressure wound therapy; local antibiotics; bead pouch;
   orthopaedic infection
ID VACUUM-ASSISTED CLOSURE; BEADS; FRACTURES; RELEASE
AB Objectives: Negative pressure wound therapy (NPWT) has been used to help manage open wounds. Surgeons also often use local antibiotic depot as adjunctive therapy in an effort to reduce infection rates. These 2 techniques have been reported to be used in conjunction, but there are little data to support this practice. We sought to compare the contamination levels of wounds treated with the commonly used antibiotic bead pouch technique to wounds that received both antibiotic beads and NWPT.
   Methods: The effectiveness of a bead pouch was compared with antibiotic beads with NPWT. The anterior compartment and proximal tibia of goats were injured and inoculated with Staphylococcus aureus. Six hours later, the wounds were debrided and the animals were assigned to a group; the bacteria level was quantified immediately before and after initial debridement and 2 days after treatment.
   Results: The wounds in the antibiotic bead pouch group had 6-fold less bacteria than the augmented NPWT group, 11 + 2% versus 67 + 11% of baseline values, respectively (P = 0.01). As expected, high levels of the antibiotic were consistently recovered from the augmented NPWT effluent samples at all time points.
   Conclusions: NPWT reduces the effectiveness of local antibiotic depot. These results can provide surgeons with the information to personalize the adjunctive therapies to individual patients, with the degree of difficulty in managing the wound and concern for infection being the 2 variables dictating treatment.
C1 [Stinner, Daniel J.; Wenke, Joseph C.] USA, Dept Regenerat Med, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Hsu, Joseph R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
C3 United States Department of Defense; United States Army; Brooke Army
   Medical Center
RP Stinner, DJ (通讯作者)，USA, Dept Regenerat Med, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
EM daniel.stinner@gmail.com
RI Stinner, Daniel/KSM-9513-2024
OI Stinner, Daniel/0000-0002-8981-6262; Hsu, Joseph/0000-0001-9341-2554
FU intramural federal funding
FX This project was supported by intramural federal funding.
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NR 30
TC 35
Z9 40
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2012
VL 26
IS 9
BP 512
EP 518
DI 10.1097/BOT.0b013e318251291b
PG 7
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 999YQ
UT WOS:000308352200016
PM 22495524
DA 2026-07-24
ER
PT J
AU Streubel, PN
   Stinner, DJ
   Obremskey, WT
AF Streubel, Philipp N.
   Stinner, Daniel J.
   Obremskey, William T.
TI Use of Negative-pressure Wound Therapy in Orthopaedic Trauma
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; SEALING-TECHNIQUE; OPEN
   FRACTURES; TRIAL; CONTAMINATION; INFECTIONS; EXPERIENCE; MANAGEMENT;
   DRESSINGS
AB Negative-pressure wound therapy (NPWT) has become an important adjunct to the management of traumatic wounds and surgical incisions related to musculoskeletal trauma. On the battlefield, this adjunct therapy allows early wound management and safe aeromedical evacuation. NPWT mechanisms of action include stabilization of the wound environment, reduction of wound edema, improvement of tissue perfusion, and stimulation of cells at the wound surface. NPWT stimulates granulation tissue and angiogenesis and may improve the likelihood of primary closure and reduce the need for free tissue transfer. In addition, NPWT reduces the bacterial bioburden of wounds contaminated with gram-negative bacilli. However, an increased risk of colonization of gram-positive cocci (eg, Staphylococcus aureus) exists. Although NPWT facilitates wound management, further research is required to determine conclusively whether this modality is superior to other management options. Ongoing research will continue to define the indications for and benefits of NPWT as well as establish the role of combination therapy, in which NPWT is used with instillation of antibiotic solutions, placement of antibiotic-laden cement beads, or silver-impregnated sponges.
C1 [Streubel, Philipp N.; Obremskey, William T.] Vanderbilt Univ, Ctr Med, Div Orthopaed Trauma, Nashville, TN 37232 USA.
   [Stinner, Daniel J.] Brooke Army Med Ctr, San Antonio, TX USA.
C3 Vanderbilt University; United States Department of Defense; United
   States Army; Brooke Army Medical Center
RP Streubel, PN (通讯作者)，Vanderbilt Univ, Ctr Med, Div Orthopaed Trauma, Nashville, TN 37232 USA.
RI Stinner, Daniel/KSM-9513-2024; Obremskey, William/HRA-4704-2023
OI Stinner, Daniel/0000-0002-8981-6262; Obremskey,
   William/0000-0002-8942-1842; Streubel, Philipp/0000-0002-4585-1779
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NR 41
TC 74
Z9 90
U1 0
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD SEP
PY 2012
VL 20
IS 9
BP 564
EP 574
DI 10.5435/JAAOS-20-09-564
PG 11
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 000JK
UT WOS:000308382400003
PM 22941799
DA 2026-07-24
ER
PT J
AU Deniz, H
   Gokaslan, G
   Arslanoglu, Y
   Ozcaliskan, O
   Guzel, G
   Yasim, A
   Ustunsoy, H
AF Deniz, Hayati
   Gokaslan, Gokhan
   Arslanoglu, Yavuz
   Ozcaliskan, Ozerdem
   Guzel, Gokalp
   Yasim, Alptekin
   Ustunsoy, Hasim
TI Treatment outcomes of postoperative mediastinitis in cardiac surgery;
   negative pressure wound therapy versus conventional treatment
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Cardiac surgery; Sternal wound infection; Negative pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; BYPASS GRAFT-SURGERY; LONG-TERM SURVIVAL;
   POSTSTERNOTOMY MEDIASTINITIS; MUSCLE FLAPS; SUCTION DRAINAGE; HEART
   SURGERY; RISK-FACTORS; INFECTION; STERNOTOMY
AB Background: The aim of the present study is to compare negative pressure wound therapy versus conventional treatment outcomes at postoperative mediastinitis after cardiac surgery.
   Methods: Between January 2000 and December 2011, after 9972 sternotomies, postoperative mediastinitis was diagnosed in 90 patients. The treatment modalities divided the patients into two groups: group 1 patients (n = 47) were initially treated with the negative pressure wound therapy and group 2 patients (n = 43) were underwent conventional treatment protocols. The outcomes were investigated with Kaplan-Meier method, log-rank test, Student's test and Fisher's exact test.
   Results: The 90-days mortality was found significantly lower in the negative pressure wound group than in the conventionally treated group. Overall survival was significantly better in the negative pressure wound group than in the conventionally treated group.
   Conclusion: Negative pressure wound therapy is safe and reliable option in mediastinitis after cardiac surgery, with excellent survival and low failure rate when compared with conventional treatments.
C1 [Deniz, Hayati; Gokaslan, Gokhan; Arslanoglu, Yavuz; Ozcaliskan, Ozerdem; Guzel, Gokalp; Yasim, Alptekin; Ustunsoy, Hasim] Gaziantep Univ, Fac Med, Dept Cardiovasc Surg, TR-27310 Sehitkamil, Gaziantep, Turkey.
C3 Gaziantep University
RP Deniz, H (通讯作者)，Gaziantep Univ, Fac Med, Dept Cardiovasc Surg, TR-27310 Sehitkamil, Gaziantep, Turkey.
EM hayatideniz@gmail.com
RI Güzel, Gökalp/JPX-0148-2023; Ozcaliskan, Ozerdem/M-9720-2018;
   ARSLANOGLU, YAVUZ/JLK-8285-2023
OI Güzel, Gökalp/0000-0003-0377-3095; Ozcaliskan,
   Ozerdem/0000-0002-4121-7068; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Assmann A, 2011, THORAC CARDIOV SURG, V59, P25, DOI 10.1055/s-0030-1250598
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   De Feo M, 2001, ANN THORAC SURG, V71, P324, DOI 10.1016/S0003-4975(00)02137-8
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   JULIAN OC, 1957, SURGERY, V42, P753
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   Simek M, 2012, J CARDIOVASC SURG, V53, P113
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   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
   Wettstein R, 2002, J THORAC CARDIOV SUR, V123, P1185, DOI 10.1067/mtc.2002.121304
NR 32
TC 30
Z9 39
U1 1
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD JUL 11
PY 2012
VL 7
AR 67
DI 10.1186/1749-8090-7-67
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 001DC
UT WOS:000308439200001
PM 22784512
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Juhl, AA
   Koudahl, V
   Damsgaard, TE
AF Juhl, Alexander Andersen
   Koudahl, Vibeke
   Damsgaard, Tine Engberg
TI Deep sternal wound infection after open heart surgery - reconstructive
   options
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Review
DE deep sternal wound infection; TNP; mediastinitis; surgical flaps;
   reconstructive surgical procedures; sternum surgery; surgical wound
   infection; review; open heart surgery
ID VACUUM-ASSISTED CLOSURE; EMORY 20-YEAR EXPERIENCE; MUSCLE FLAPS;
   POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY; STERNOTOMY WOUNDS;
   PECTORALIS FLAPS; MANAGEMENT; THERAPY; IMPACT
AB Objectives. The management of sternal defects arisen after deep sternal wound infection is challenging and often requires extensive interdisciplinary teamwork between plastic and thoracic surgeons. In this study, the published literature on methods used to reconstruct sternal defects arisen as a result of deep sternal wound infection after open-heart surgery will be reviewed. Design. The Cochrane, Embase, PubMed, and SveMed + databases were searched in December 2011. Only papers regarding treatment of deep sternal wound infection after open-heart surgery in adults were included. Results. The literature search identified 224 original papers that met the inclusion criteria. The majority dealt with surgical techniques. None of the studies regarding reconstructive options were designed as randomized controlled trials, and the levels of evidence are generally low. Conclusion. The treatment of deep sternal wound infection has evolved considerably, but there is still little consensus regarding optimal surgical management and a general lack of a standard treatment protocol. The use of muscle flap transposition is well documented. Recent studies recommend the use of topical negative pressure therapy as an adjunct to surgical reconstruction.
C1 [Juhl, Alexander Andersen; Koudahl, Vibeke; Damsgaard, Tine Engberg] Aarhus Univ Hosp, Dept Plast Surg, DK-8000 Aarhus C, Denmark.
C3 Aarhus University
RP Juhl, AA (通讯作者)，Aarhus Univ Hosp, Dept Plast Surg, Norrebrogade 44, DK-8000 Aarhus C, Denmark.
EM alexander@oncology.dk
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   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
NR 30
TC 20
Z9 27
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PD OCT
PY 2012
VL 46
IS 5
BP 254
EP 261
DI 10.3109/14017431.2012.674549
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 002LU
UT WOS:000308534400002
PM 22404844
DA 2026-07-24
ER
PT J
AU Foroulis, CN
   Karapanagiotidis, G
   Papakonstantinou, C
AF Foroulis, Christophoros N.
   Karapanagiotidis, Georgios
   Papakonstantinou, Christos
TI Pericardial Patch Tracheoplasty for the Repair of a Long, Multisegmental
   Postintubation Tracheal Damage
SO ARTIFICIAL ORGANS
LA English
DT Article
DE Tracheal stenosis; Tracheoplasty; Pericardial patch
ID REPLACEMENT; STENOSIS; DEFECTS
AB A 64-year-old man was admitted with a postintubation, multisegmental tracheal damage comprising of two stenotic lesions, below and above a tracheotomy. The patient underwent resection of the damaged anterolateral tracheal wall through a combined collar-cuff and median sternotomy incision and tracheoplasty with autologous pericardium around a Silastic T-tube that was fixed to the cricoid cartilage, healthy distal trachea, and the remaining membranous wall. The postoperative period was complicated with a deep sternal wound infection that was successfully treated with vacuum-assisted closure for 2 weeks. Removal of the T-tube 9 months later resulted in a patent and well-functioning airway. Pericardial patch tracheoplasty and T-tube stenting of the repair for several months is a good alternative to extended tracheal resection for the treatment of the rare long, postintubation multisegmental tracheal damage. The pericardial patch is highly resistant to infection and allows the formation of a neotrachea.
C1 [Foroulis, Christophoros N.; Karapanagiotidis, Georgios; Papakonstantinou, Christos] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Thorac & Cardiovasc Surg, Sch Med, Thessaloniki 54636, Greece.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital
RP Foroulis, CN (通讯作者)，Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Thorac & Cardiovasc Surg, Sch Med, 1 Stilponos Kiriakidi St, Thessaloniki 54636, Greece.
EM cforoulis@otenet.gr
RI Foroulis, Christophoros/ABD-9464-2021
OI Foroulis, Christophoros/0000-0002-5708-7210; Karapanagiotidis,
   Georgios/0000-0002-2065-7646
CR Abbasidezfouli A, 2007, ANN THORAC SURG, V84, P211, DOI 10.1016/j.athoracsur.2007.03.050
   Bando K, 1996, ANN THORAC SURG, V62, P981, DOI 10.1016/0003-4975(96)00478-X
   BRYANT LR, 1964, J THORAC CARDIOV SUR, V48, P733, DOI 10.1016/S0022-5223(19)33356-2
   Cheng ATL, 1997, ARCH OTOLARYNGOL, V123, P1069
   Foroulis Christophoros N, 2003, Interact Cardiovasc Thorac Surg, V2, P595, DOI 10.1016/S1569-9293(03)00142-7
   Grillo HC, 2002, ANN THORAC SURG, V73, P1995, DOI 10.1016/S0003-4975(02)03564-6
   GRILLO HC, 1990, EUR J CARDIO-THORAC, V4, P573, DOI 10.1016/1010-7940(90)90149-T
   TOCEWICZ K, 1993, EUR J CARDIO-THORAC, V7, P101, DOI 10.1016/1010-7940(93)90189-I
NR 8
TC 2
Z9 3
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-564X
J9 ARTIF ORGANS
JI Artif. Organs
PD SEP
PY 2012
VL 36
IS 9
BP 835
EP 839
DI 10.1111/j.1525-1594.2011.01435.x
PG 5
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA 003EL
UT WOS:000308590900014
PM 22428774
DA 2026-07-24
ER
PT J
AU Kafka-Ritsch, R
   Birkfellner, F
   Perathoner, A
   Raab, H
   Nehoda, H
   Pratschke, J
   Zitt, M
AF Kafka-Ritsch, Reinhold
   Birkfellner, Franz
   Perathoner, Alexander
   Raab, Helmut
   Nehoda, Hermann
   Pratschke, Johann
   Zitt, Matthias
TI Damage Control Surgery with Abdominal Vacuum and Delayed Bowel
   Reconstruction in Patients with Perforated Diverticulitis Hinchey III/IV
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article
DE Perforated; Diverticulitis; Hinchey; Abdominal; Vacuum; Anastomosis
ID LAPAROSCOPIC PERITONEAL-LAVAGE; HARTMANNS PROCEDURE; SIGMOID
   DIVERTICULITIS; PRIMARY ANASTOMOSIS; COMPLICATED DIVERTICULITIS;
   GENERALIZED PERITONITIS; ASSISTED CLOSURE; COLECTOMY; RESECTION;
   REVERSAL
AB With the use of abdominal vacuum therapy, we have developed a damage control concept for patients with perforated diverticulitis and generalized peritonitis. The primary aim of this concept was to enhance recovery and allow bowel reconstruction in a second-look operation.
   A total of 51 patients (28 female, 55 %) with a median (range) age of 69 (28-87) years, with perforated diverticulitis Hinchey III (n = 40, 78 %) or Hinchey IV (n = 11, 22 %) and a median (range) Mannheim peritonitis index of 26 (12-39), admitted between October 2006 and September 2011, were prospectively enrolled in the study. At initial operation, limited resection of the diseased segment, lavage, and application of abdominal vacuum-assisted closure dressing was performed. After patient resuscitation, a second look was performed in an elective setting.
   Hospital mortality rate was 9.8 %; 35 (76 %) of patients were discharged with reconstructed colon, and 93 % of patients live without a stoma at follow-up. Risk factors for mortality were American Society of Anesthesiologist score (p = 0.01), organ failure at initial presentation (p = 0.03), cardiac comorbidity (p = 0.05), and a Hartmann procedure at second look (p = 0.00).
   With this abdominal vacuum-based damage control concept, an acceptable hospital mortality rate and a high rate of bowel reconstruction at second look were achieved in patients with perforated diverticulitis and generalized peritonitis.
C1 [Kafka-Ritsch, Reinhold; Perathoner, Alexander; Pratschke, Johann; Zitt, Matthias] Innsbruck Med Univ, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, A-6020 Innsbruck, Austria.
   [Birkfellner, Franz; Nehoda, Hermann] St Johann Tirol Hosp, A-6380 St Johann In Tirol, Austria.
   [Raab, Helmut] Innsbruck Med Univ, Dept Anaesthesiol, Ctr Operat Med, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck; Medical University of Innsbruck
RP Kafka-Ritsch, R (通讯作者)，Innsbruck Med Univ, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, Anichstr 35, A-6020 Innsbruck, Austria.
EM reinhold.kafka-ritsch@uki.at
CR Alvarez JA, 2007, DIGEST SURG, V24, P471, DOI 10.1159/000111823
   Chapman J, 2005, ANN SURG, V242, P576, DOI 10.1097/01.sla.0000184843.89836.35
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   Tan KK, 2011, J GASTROINTEST SURG, V15, P277, DOI 10.1007/s11605-010-1330-8
   Vermeulen J, 2009, COLORECTAL DIS, V11, P619, DOI 10.1111/j.1463-1318.2008.01667.x
   Vermeulen J, 2007, DIGEST SURG, V24, P361, DOI 10.1159/000107719
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   Zingg U, 2010, COLORECTAL DIS, V12, P54, DOI 10.1111/j.1463-1318.2008.01694.x
NR 27
TC 75
Z9 82
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1091-255X
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD OCT
PY 2012
VL 16
IS 10
BP 1915
EP 1922
DI 10.1007/s11605-012-1977-4
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 008KF
UT WOS:000308955100014
PM 22843083
DA 2026-07-24
ER
PT J
AU Iblher, N
   Fritsche, HM
   Katzenwadel, A
   Penna, V
   Eisenhardt, SU
   Stark, GB
   Lampert, F
AF Iblher, N.
   Fritsche, H. -M.
   Katzenwadel, A.
   Penna, V.
   Eisenhardt, S. U.
   Stark, G. B.
   Lampert, F.
TI Refinements in reconstruction of penile skin loss using intra-operative
   prostaglandin injections, postoperative tadalafil application and
   negative pressure dressings
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Skin graft; Penile reconstruction; Negative-pressure wound therapy;
   Tadalafil; PDE5-inhibitor; Prostaglandin
ID VACUUM-ASSISTED CLOSURE; FLAP SURVIVAL; ERECTILE DYSFUNCTION; WOUND
   CONTRACTION; GRAFTS; SILDENAFIL; RATS; MANAGEMENT; SHAFT
AB Purpose: Penile shaft skin defects represent demanding reconstructive tasks because a high degree of flexibility and stability of the skin grafts are essential to allow regular erections and sexual intercourse.
   Methods: A new concept of tailoring skin grafts to the erect penis by intra-operative application of prostaglandin E1 and postoperative stabilisation by negative-pressure wound therapy and pharmacological expansion by tadalafil was tested on four patients with penile shaft skin defects. Graft take, stability, pliability, softness and aesthetic results were evaluated up to at least 12 months postoperatively. The ratio of the skin transplanted area in the non-erect compared to the erect penis (non-erect/erect ratio) and the ratio of the skin transplanted area in the erect penis at 12 months compared to intra-operatively (Post/Pre ratio) was determined to define the amount of graft contraction and flexibility. International Index of Erectile Function (IIEF)-5 scores were evaluated postoperatively.
   Results: There were no complications. Graft take was 97, 100, 100 and 100%. Stable skin grafts were achieved after 2 weeks. Sexual intercourse was possible at 2-3 months. The Post/Pre ratio was between 81 and 87% and proves comparably mild contracture rates. The non-erect/erect ratio of 50-72% shows how significantly undersized penile shaft skin grafts are when adjusted to the non-erect penis and that an adequate flexibility for erections can be reconstructed. IIEF-5 scores proved regular potency in three patients; one patient was no longer sexually active.
   Conclusions: With the new concept of tailoring the skin graft to the erect penis, pharmacological expansion and external stabilisation by vacuum-assisted closure (VAC) dressing the difficult task of penile skin reconstruction can be facilitated, accelerated and the functional and aesthetic outcome improved compared to earlier efforts or to results presented in the literature. (C) 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Iblher, N.; Penna, V.; Eisenhardt, S. U.; Stark, G. B.; Lampert, F.] Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Freiburg, Germany.
   [Fritsche, H. -M.] Caritas Krankenhaus St Josef, Dept Urol, Regensburg, Germany.
   [Katzenwadel, A.] Univ Freiburg, Med Ctr, Dept Urol, Freiburg, Germany.
C3 University of Freiburg; University of Freiburg
RP Iblher, N (通讯作者)，Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Freiburg, Germany.
EM niklas.iblher@uniklinik-freiburg.de
RI ; Eisenhardt, Steffen Ulrich/AAF-8033-2021
OI Lampert, Florian/0000-0003-4052-0601; Eisenhardt, Steffen
   Ulrich/0000-0003-4471-3160
CR Bandera BC, 2005, AM SURGEON, V76, P614
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   Eisenhardt SU, 2010, J RECONSTR MICROSURG, V26, P615, DOI 10.1055/s-0030-1267378
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NR 27
TC 10
Z9 10
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD OCT
PY 2012
VL 65
IS 10
BP 1377
EP 1383
DI 10.1016/j.bjps.2012.04.020
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 008ZS
UT WOS:000308995700020
PM 22633389
DA 2026-07-24
ER
PT J
AU Roberts, DJ
   Zygun, DA
   Grendar, J
   Ball, CG
   Robertson, HL
   Ouellet, JF
   Cheatham, ML
   Kirkpatrick, AW
AF Roberts, Derek J.
   Zygun, David A.
   Grendar, Jan
   Ball, Chad G.
   Robertson, Helen Lee
   Ouellet, Jean-Francois
   Cheatham, Michael L.
   Kirkpatrick, Andrew W.
TI Negative-pressure wound therapy for critically ill adults with open
   abdominal wounds: A systematic review
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Abdominal injuries; intra-abdominal sepsis; temporary abdominal closure;
   vacuum-assisted wound closure; wounds and injuries
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; FASCIAL CLOSURE; COMPARTMENT
   SYNDROME; INTRAABDOMINAL HYPERTENSION; TEMPORARY CLOSURE;
   CLINICAL-TRIALS; VENTRAL HERNIA; TRAUMA; MANAGEMENT
AB BACKGROUND: Open abdominal management with negative-pressure wound therapy (NPWT) is increasingly used for critically ill trauma and surgery patients. We sought to determine the comparative efficacy and safety of NPWT versus alternate temporary abdominal closure (TAC) techniques in critically ill adults with open abdominal wounds.
   METHODS: We conducted a systematic review of published and unpublished comparative studies. We searched MEDLINE, PubMed, EMBASE, Scopus, Web of Science, the Cochrane Database, the Center for Reviews and Dissemination, clinical trials registries, and bibliographies of included articles. Two authors independently abstracted data on study design, methodological quality, patient characteristics, and outcomes.
   RESULTS: Among 2,715 citations identified, 2 randomized controlled trials and 9 cohort studies (3 prospective/6 retrospective) met inclusion criteria. Methodological quality of included prospective studies was moderate. One randomized controlled trial observed an improved fascial closure rate (relative risk [RR], 2.4; 95% confidence interval [CI], 1.0-5.3) and length of hospital stay after addition of retention sutured sequential fascial closure to the Kinetic Concepts Inc. (KCI) vacuum-assisted closure (VAC). Another reported a trend toward enhanced fascial closure using the KCI VAC versus Barker's vacuum pack (RR, 2.6; 95% CI, 0.95-7.1). A prospective cohort study observed improved mortality (RR, 0.48; 95% CI, 0.25-0.92) and fascial closure (RR, 1.5; 95% CI, 1.1-2.0) for patients who received the ABThera versus Barker's vacuum pack. Another noted a reduced arterial lactate, intra-abdominal pressure, and hospital stay for those fitted with the KCI VAC versus Bogota bag. Most included retrospective studies exhibited low methodological quality and reported no mortality or fascial closure benefit for NPWT.
   CONCLUSION: Limited prospective comparative data suggests that NPWT versus alternate TAC techniques may be linked with improved outcomes. However, the clinical heterogeneity and quality of available studies preclude definitive conclusions regarding the preferential use of NPWT over alternate TAC techniques. (J Trauma Acute Care Surg. 2012; 73: 629-639. Copyright (C) 2012 by Lippincott Williams & Wilkins)
C1 [Roberts, Derek J.; Grendar, Jan; Ball, Chad G.; Ouellet, Jean-Francois; Kirkpatrick, Andrew W.] Univ Calgary, Dept Surg, Calgary, AB T2N 2T9, Canada.
   [Roberts, Derek J.; Zygun, David A.] Univ Calgary, Dept Community Hlth Sci, Calgary, AB T2N 2T9, Canada.
   [Roberts, Derek J.; Zygun, David A.; Kirkpatrick, Andrew W.] Univ Calgary, Dept Crit Care Med, Calgary, AB T2N 2T9, Canada.
   [Zygun, David A.] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 2T9, Canada.
   [Ball, Chad G.; Ouellet, Jean-Francois; Kirkpatrick, Andrew W.] Univ Calgary, Reg Trauma Program, Calgary, AB T2N 2T9, Canada.
   [Robertson, Helen Lee] Univ Calgary, Hlth Sci Lib, Calgary, AB T2N 2T9, Canada.
   [Roberts, Derek J.; Zygun, David A.; Grendar, Jan; Ball, Chad G.; Ouellet, Jean-Francois; Kirkpatrick, Andrew W.] Foothills Med Ctr, Calgary, AB, Canada.
   [Cheatham, Michael L.] Orlando Reg Med Ctr Inc, Dept Surg Educ, Orlando, FL USA.
C3 University of Calgary; University of Calgary; University of Calgary;
   University of Calgary; University of Calgary; University of Calgary;
   University of Calgary; University Calgary Hospital; Orlando Health;
   Orlando Regional Medical Center
RP Kirkpatrick, AW (通讯作者)，Univ Calgary, Dept Surg, 1403-29th St, Calgary, AB T2N 2T9, Canada.
EM Andrew.Kirkpatrick@AlbertaHealthServices.Ca
RI Roberts, Derek/L-6229-2019; Robertson, Helen Lee/AAH-2875-2019
OI Roberts, Derek/0000-0001-6111-6291; Robertson, Helen
   Lee/0000-0002-2348-2239
FU University of Calgary; KCI [KCI Clinical/University Calgary Alberta
   Health/082611-000/7]; KCI USA
FX Dr. Kirkpatrick has an investigator-initiated trial agreement with KCI
   USA and the Governors of the University of Calgary for funding of a
   randomized comparison of baseline wall suction and the ABThera open
   abdomen NPT system for adults with critical illness and open abdominal
   wounds (KCI contract number: KCI Clinical/University Calgary Alberta
   Health/082611-000/7). Dr. Cheatham has received compensation from KCI
   USA as a lecturer and is an investigator on the included ABTAC-50 study.
   The remaining authors have no conflicts of interest to declare. Dr.
   Roberts is supported by funding from the Clinician Investigator and
   Surgeon Scientist Programs at the University of Calgary. These
   institutions had no role in the design and conduct of the study;
   collection, management, analysis, and interpretation of the data; or
   preparation, review, or approval of the article.
CR [Anonymous], 5 WORLD C ABD COMP S
   [Anonymous], COCHRANE HDB SYSTEMA
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NR 48
TC 92
Z9 114
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD SEP
PY 2012
VL 73
IS 3
BP 629
EP 639
DI 10.1097/TA.0b013e31825c130e
PG 11
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 009TK
UT WOS:000309047900015
PM 22929494
DA 2026-07-24
ER
PT J
AU Dowsett, C
   Davis, L
   Henderson, V
   Searle, R
AF Dowsett, Caroline
   Davis, Lynn
   Henderson, Valerie
   Searle, Richard
TI The economic benefits of negative pressure wound therapy in
   community-based wound care in the NHS
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Community; Database; Health economics; Negative pressure wound therapy;
   Wound care
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; ULCERS;
   MULTICENTER; COST
AB The human and economic costs of wounds are of major concern within today's National Health Service. Advances in wound care technology have been shown to be beneficial both in healing and in relation to patient quality of life. Negative pressure has often been associated with high-cost care and restricted to use in the secondary care setting. There is growing use of negative pressure within the community, and this has the potential to benefit the patient and the service by providing quality care in the patient's home setting. Three community sites were chosen to monitor their use of negative pressure wound therapy (NPWT) over a period of 2 years, and this paper presents some of the key findings of this work. The data generated has been used to help target resources and prevent misuse of therapy. Cost per patient episode has been calculated, and this can be compared to similar costs in secondary care, showing significant savings if patients are discharged earlier from secondary care. There is also an increased demand for more patients with complex wounds to be cared for in the community, and in the future, it is likely that community initiated NPWT may become more common. Early analysis of the data showed that the average cost of dressing complex wounds would be significantly less than using traditional dressings, where increased nursing visits could increase costs. There is a compelling argument for more negative pressure to be used and initiated in the community, based not only on improved quality of life for patients but also on the economic benefits of the therapy.
C1 [Searle, Richard] Smith & Nephew Healthcare, Kingston Upon Hull, N Humberside, England.
   [Dowsett, Caroline] E London NHS Fdn Trust, London, England.
C3 Smith & Nephew
RP Searle, R (通讯作者)，Smith & Nephew Healthcare, Kingston Upon Hull, N Humberside, England.
EM Richard.searle@smith-nephew.com
CR [Anonymous], 2008, BEST PRACT STAT GAUZ
   [Anonymous], TRANSF COMM SERV
   [Anonymous], 2010, EQ EXC LIB NHS
   [Anonymous], 2010, NHS OUTC FRAM 2011 1
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   Department of Health, 2011, UK DRUG TAR MAY 2011
   Drew Philip, 2007, Int Wound J, V4, P149, DOI 10.1111/j.1742-481X.2007.00337.x
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NR 17
TC 38
Z9 44
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2012
VL 9
IS 5
BP 544
EP 552
DI 10.1111/j.1742-481X.2011.00913.x
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 010AG
UT WOS:000309066200011
PM 22321132
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Tian, M
   Wang, XQ
   Xiao, YR
   Lu, SL
   Jiang, YZ
AF Tian, Ming
   Wang, Xiqiao
   Xiao, Yurui
   Lu, Shuliang
   Jiang, Yuzhi
TI A Successful Rescue of Systematic Inflammatory Response Syndrome
   Resulting From Severe Wound Infection
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE systematic inflammatory response syndrome; SIRS; debridement; topical
   negative pressure; antibiotics; local wound infection
ID VACUUM-ASSISTED CLOSURE; THERAPY; MULTICENTER
AB This article reports a critical case of systematic inflammatory response syndrome (SIRS) due to wound infection. By intensive local wound treatment including debridement, topical negative pressure, and topical antibiotics, SIRS was effectively controlled, vital signs stabilized, and the wound healed in 45 days. This case reflects the close association between wound infection and SIRS while highlighting early diagnosis of local pathology and local treatment.
C1 [Tian, Ming; Wang, Xiqiao; Xiao, Yurui; Lu, Shuliang; Jiang, Yuzhi] Shanghai Jiao Tong Univ, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University
RP Jiang, YZ (通讯作者)，Shanghai Jiao Tong Univ, Dept Trauma Repair, Shanghai Burns Inst, Ruijin Hosp,Sch Med, Shanghai 200025, Peoples R China.
EM yuzhijiang.med@gmail.com
OI Tian, Ming/0000-0003-1665-321X
FU key projects in the National Science & Technology Pillar Program
   [2012BAI11B04]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   authors are supported by key projects in the National Science &
   Technology Pillar Program (2012BAI11B04).
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 10
TC 1
Z9 1
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2012
VL 11
IS 3
SI SI
BP 152
EP 154
DI 10.1177/1534734612456395
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 010EX
UT WOS:000309078600004
PM 22885608
DA 2026-07-24
ER
PT J
AU Coban, YK
AF Coban, Yusuf Kenan
TI Combination of Negative Pressure Wound Therapy and Hyalomatrix
   Application for Soft Tissue Defect of the Great Toe
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE great toe; soft tissue defect; combination therapy
AB Soft tissue defect of the hallux can be particularly difficult to manage because of the absence of local muscle tissue for coverage. The author presents his experience of a combination therapy for severe posttraumatic soft tissue defect of the hallux in a young patient.
C1 Inonu Univ, Fac Med, Dept Plast Surg, TR-44280 Malatya, Turkey.
C3 Inonu University
RP Coban, YK (通讯作者)，Inonu Univ, Fac Med, Dept Plast Surg, TR-44280 Malatya, Turkey.
EM ykenanc@yahoo.com
RI Coban, Yusuf Kenan/AAV-8105-2020
OI Coban, Yusuf Kenan/0000-0003-3009-8339
CR Cigna E, 2013, INT WOUND J, V10, P534, DOI 10.1111/j.1742-481X.2012.01011.x
   Demirtas Y, 2010, MICROSURG, V30, P24, DOI 10.1002/micr.20696
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   Xie X, 2010, J WOUND CARE, V19, P488
NR 5
TC 6
Z9 10
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2012
VL 11
IS 3
SI SI
BP 155
EP 156
DI 10.1177/1534734612456396
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 010EX
UT WOS:000309078600005
PM 22843635
DA 2026-07-24
ER
PT J
AU Tian, M
   Wang, XQ
   Xiao, YR
   Lu, SL
   Jiang, YZ
AF Tian, Ming
   Wang, Xiqiao
   Xiao, Yurui
   Lu, Shuliang
   Jiang, Yuzhi
TI A Rare Case of Diabetic Hand Ulcer Caused by Streptococcus
   agalactiae
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE diabetic hand ulcer; Streptococcus agalactiae; negative pressure wound
   therapy
ID FOOT ULCERS
AB This study reports the case of a 71-year-old woman with type 2 diabetes whose paronychia rapidly progressed to the right middle finger and then to the whole dorsal aspect necrosis of the right hand. After admission, the diagnosis of diabetic hand ulcer was established and Streptococcus agalactiae found as the pathogen. The authors controlled glucose, used 3% hydrogen peroxide and sulfadiazine silver in routine dressing, as well as surgical debridement, topical negative pressure, and skin grafting. The wound closed in 32 days after surgery. Diabetic hand ulcer is often developed from a small wound. The wound, if neglected, will expand very quickly and may lead to amputation and even death. So early diagnosis, standardized treatment, and postoperative rehabilitation is very important.
C1 [Tian, Ming; Wang, Xiqiao; Xiao, Yurui; Lu, Shuliang; Jiang, Yuzhi] Shanghai Jiao Tong Univ, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University
RP Jiang, YZ (通讯作者)，Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Shanghai Burns Inst, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China.
EM yuzhi.jiang@hotmail.com
OI Tian, Ming/0000-0003-1665-321X
FU National Natural Science Foundation of China [30700871, 30600645,
   81071568, 2005CB522603]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Supported
   by the National Natural Science Foundation of China (30700871, 30600645,
   81071568, 2005CB522603).
CR AKINTEWE TA, 1983, TROP GEOGR MED, V35, P353
   Archibald LK, 1997, DIABETIC MED, V14, P607, DOI 10.1002/(SICI)1096-9136(199707)14:7<607::AID-DIA395>3.0.CO;2-G
   Gill GV, 1998, LANCET, V351, P113, DOI 10.1016/S0140-6736(05)78146-0
   Houshian S, 2006, INT J INFECT DIS, V10, P315, DOI 10.1016/j.ijid.2005.06.009
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NR 9
TC 4
Z9 5
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2012
VL 11
IS 3
SI SI
BP 174
EP 176
DI 10.1177/1534734612457032
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 010EX
UT WOS:000309078600011
PM 22863692
DA 2026-07-24
ER
PT J
AU Jordan, CJ
   Kulendra, E
   Perry, KL
   Halfacree, ZJ
AF Jordan, C. J.
   Kulendra, E.
   Perry, K. L.
   Halfacree, Z. J.
TI Management of peristomal tissue necrosis following prepubic urethrostomy
   in a cat
SO VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
LA English
DT Article
DE Prepubic urethrostomy; vacuum assisted closure; urogenital;
   reconstructive surgery; temporary urethral ligation
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; SKIN; DOGS
AB This report describes the successful management of peristomal tissue necrosis following prepubic urethrostomy in a cat. The novel technique of temporary urethral ligation was used in combination with temporary tube cystostomy and vacuum assisted closure to allow for wound management prior to performing wound closure by utilization of a flank fold skin flap then definitive prepubic urethrostomy. Eleven month follow-up indicated excellent outcome with the cat having returned to normal behaviour apart from having adapted its posture to urinate.
C1 [Kulendra, E.; Perry, K. L.; Halfacree, Z. J.] Royal Vet Coll, Small Anim Med & Surg Grp, Hatfield, Herts, England.
C3 University of London; University of London Royal Veterinary College
RP Jordan, CJ (通讯作者)，Poles Lane, Winchester SO21 2LL, Hants, England.
EM chris@andersonmoores.com
RI Perry, Karen/AAY-7641-2020
OI Perry, Karen/0000-0001-6456-1817; Halfacree, Zoe/0000-0001-6891-8828;
   Kulena, Elvin/0000-0002-2026-3065
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baines SJ, 2001, VET SURG, V30, P107, DOI 10.1053/jvet.2001.20327
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   Bjorling D, 2003, TXB SMALL ANIMAL SUR, P1645
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   Hosgood G, 2003, TXB SMALL ANIMAL SUR, P67
   HUNT GB, 1995, VET SURG, V24, P172, DOI 10.1111/j.1532-950X.1995.tb01312.x
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   Owen LJ, 2009, VET COMP ORTHOPAED, V22, P417, DOI 10.3415/VCOT-08-12-0123
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   Tang Su-yang, 2004, Zhonghua Zheng Xing Wai Ke Za Zhi, V20, P139
NR 19
TC 6
Z9 7
U1 0
U2 5
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0932-0814
EI 2567-6911
J9 VET COMP ORTHOPAED
JI Vet. Comp. Orthop. Traumatol.
PY 2012
VL 25
IS 5
BP 433
EP 437
DI 10.3415/VCOT-11-11-0168
PG 5
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA 012QU
UT WOS:000309252400014
PM 22829103
OA Bronze
DA 2026-07-24
ER
PT J
AU Acosta, S
   Monsen, C
AF Acosta, S.
   Monsen, C.
TI Outcome after VAC® Therapy for Infected Bypass Grafts in the Lower Limb
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE VAC; Negative pressure wound therapy; Bypass; Graft infection; Wound
   healing; Amputation; Mortality
ID VASCULAR GRAFT; GROIN; CLOSURE
AB Objective: To assess the outcome of vacuum-assisted wound closure (VAC (R)) therapy for infected bypass grafts.
   Methods: A retrospective 7-year review of patient records from 2004 to 2011 of all patients receiving VAC (R) therapy for infected bypass grafts.
   Results: Thirty-seven patients with 42 wounds and 45 infected bypass (28 synthetic) grafts received VAC (R) treatment. Two serious bleeding episodes from the suture lines occurred. The median VAC (R) therapy time was 20 days. The proportion of patent bypass grafts was 91% (41/45) at a median time of 3.5 months from the start of VAC (R) therapy. Five patients with seven bypasses had persistent infection or re-infection, and the total graft preservation rate was 76% (34/45). The median follow-up time was 15 months. The presence of two infected bypass grafts in one groin wound was associated with an increased major amputation rate (hazard ratio (HR) 7.4 [95% confidence interval (CI) 2.0-27.5]), and synthetic graft infection (HR 5.0 [95% CI 1.5-17.4]) and non-healed wound (HR 3.6 [95% CI 1.5-8.7]) were associated with mortality.
   Conclusion: VAC (R) therapy of infected bypass grafts was able to induce effective wound healing without compromising the early bypass function. Two infected synthetic bypasses in the wound were associated with the highest risk of adverse outcome. (C) 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Acosta, S.; Monsen, C.] Skane Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
C3 Lund University; Skane University Hospital
RP Acosta, S (通讯作者)，Skane Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
EM stefan.acosta@telia.com
RI Acosta, Stefan/JAX-3225-2023; Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798; Acosta, Stefan/0000-0002-8895-6001
CR Armstrong PA, 2007, J VASC SURG, V46, P71, DOI 10.1016/j.jvs.2007.02.058
   Barani J, 2005, J VASC SURG, V42, P75, DOI 10.1016/j.jvs.2005.03.025
   Berger P, J VASC SURG
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   Dee A, 2007, J Wound Care, V16, P42
   Fischer J, 2011, J VASC SURG
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   Kragsterman B, 2011, J ENDOVASC THER, V18, P666, DOI 10.1583/11-3465.1
   Mayer D, 2011, ANN SURG, V254, P754, DOI 10.1097/SLA.0b013e3182365864
   Pinocy J, 2003, WOUND REPAIR REGEN, V11, P104, DOI 10.1046/j.1524-475X.2003.11205.x
   Reiffel A, 2011, ANN VASC SURG
   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
   SZILAGYI DE, 1972, ANN SURG, V176, P321, DOI 10.1097/00000658-197209000-00008
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NR 16
TC 18
Z9 19
U1 0
U2 2
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD SEP
PY 2012
VL 44
IS 3
BP 294
EP 299
DI 10.1016/j.ejvs.2012.06.005
PG 6
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 013KE
UT WOS:000309303500015
PM 22818802
DA 2026-07-24
ER
PT J
AU Poller, WC
   Schwerg, M
   Melzer, C
AF Poller, Wolfram C.
   Schwerg, Marius
   Melzer, Christoph
TI Therapy of Cardiac Device Pocket Infections with Vacuum-Assisted Wound
   Closure - Long-Term Follow-Up
SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
LA English
DT Article
DE cardiac device infection; local device infection; vacuum-assisted
   closure (V; A; C; ); pacemaker; implantable cardioverter defibrillator
   (AICD)
ID IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; LEAD EXTRACTION; PACEMAKER
   LEADS; POSTSTERNOTOMY MEDIASTINITIS; PERMANENT PACEMAKER; MANAGEMENT;
   REMOVAL; COMPLICATIONS; ENDOCARDITIS; EXPERIENCE
AB Background: Cardiac device infections are serious complications that require aggressive treatment strategies, including interventional or surgical lead extraction. Methods: Here we describe the long-time follow-up of vacuum-assisted closure (V.A.C.) treatment in five patients with local cardiac device infection (LDI). In these patients the device was removed, the electrodes were shortened, and a V.A.C. treatment was applied. The primary endpoint was defined as time to re-LDI. Results: Three patients had LDI of a pacemaker pocket, whereas two presented with an infection of their ICD pocket. The V.A.C. treatment was applied for 34.4 +/- 17.9 days. The mean hospitalization time was 38.6 +/- 19.2 days. The follow-up period was assessed for 34.6 +/- 19.2 months. Only one patient developed re-LDI, 69 days after removal of the device. The other four patients did not show any signs of reinfection during the follow-up period. None of the five patients sustained serious adverse events. Conclusions: V.A.C. treatment may be an option for selected patients with LDI who refuse a laser-guided lead extraction or surgical removal of the electrodes as the primary therapy. (PACE 2012; 35:12171221)
C1 [Poller, Wolfram C.; Schwerg, Marius; Melzer, Christoph] Charite, Dept Cardiol & Angiol, Berlin, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin
RP Poller, WC (通讯作者)，Med Klin Schwerpunkt Kardiol & Angiol, Charite Campus Mitte, Schumannstr 20-21, D-10117 Berlin, Germany.
EM wolfram.poller@charite.de
RI Poller, Wolfram/AAB-2185-2021
OI Poller, Wolfram/0000-0002-4632-5551
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baddour LM, 2003, CIRCULATION, V108, P2015, DOI 10.1161/01.CIR.0000093201.57771.47
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   Habib G, 2009, EUR HEART J, V30, P2369, DOI 10.1093/eurheartj/ehp285
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   Satsu T, 2010, PACE, V33, P426, DOI 10.1111/j.1540-8159.2009.02661.x
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NR 32
TC 12
Z9 16
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0147-8389
EI 1540-8159
J9 PACE
JI PACE-Pacing Clin. Electrophysiol.
PD OCT
PY 2012
VL 35
IS 10
BP 1217
EP 1221
DI 10.1111/j.1540-8159.2012.03479.x
PG 5
WC Cardiac & Cardiovascular Systems; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Engineering
GA 015MG
UT WOS:000309449600013
PM 22845624
DA 2026-07-24
ER
PT J
AU Dzieciuchowicz, L
   Kruszyna, L
   Krashiski, Z
   Espinosa, G
AF Dzieciuchowicz, Lukasz
   Kruszyna, Lukasz
   Krashiski, Zbigniew
   Espinosa, Gaudencio
TI Monitoring of Systemic Inflammatory Response in Diabetic Patients With
   Deep Foot Infection Treated With Negative Pressure Wound Therapy
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE Diabetic Foot; Negative Pressure Wound Therapy; Inflammatory Markers
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE; AMPUTATION
AB Background: The purpose of this study was to establish the safety of negative pressure wound therapy (NPWT) in the treatment of acutely debrided, deep diabetic foot infections (DDFI) and to determine the value of inflammatory markers in monitoring of treatment of these infections with negative pressure wound therapy. Methods: A group of ten patients with DDFI treated by radical surgical debridement and simultaneous NPWT was prospectively studied. During the debridement, a deep tissue sample was obtained and sent for microbiological testing. The patients were followed clinically for 10 days and NPWT dressings were changed every 2 to 3 days or sooner when indicated. The peripheral blood samples were obtained before the radical debridement and 3 and 10 days afterwards and concentrations of white blood cell, neutrophils, lymphocytes and C-reactive protein (CRP) were measured. The changes in concentration of inflammatory markers were analyzed with a Friedman test. Results: In all but one patient the presence of DDFI was confirmed by the culture results. At baseline, the elevated WBC and neutrophil concentrations were observed only in half of the patients while the CRP concentration was elevated in nine patients. During followup, all patients showed a favorable clinical evolution and statistically significant decrease of WBC, neutrophils and CRP (p < 0.001). There were not statistically significant changes in lymphocyte count. Conclusion: NPWT can be safely applied in acutely debrided DDFI. CRP seems to be the most adequate parameter for both diagnosis and monitoring of treatment of DDFI.
C1 [Dzieciuchowicz, Lukasz; Kruszyna, Lukasz; Krashiski, Zbigniew] Pozna Univ Med Sci, Dept Gen & Vasc Surg, Pozna, Poland.
   [Dzieciuchowicz, Lukasz; Espinosa, Gaudencio] Univ Navarra, Univ Hosp Pamplona, Dept Angiol & Vasc Surg, Pamplona, Spain.
C3 University of Navarra
RP Kruszyna, L (通讯作者)，Poznan Univ Med Sci, Dept Gen & Vasc Surg, Dluga 1-2 St, PL-61848 Poznan, Poland.
EM lukaszkruszyna@poczta.onet.pl
RI Dzieciuchowicz, Łukasz/GZA-8667-2022; Kruszyna, Lukasz/AAV-2308-2021
OI Kruszyna, Lukasz/0000-0001-5205-5765
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
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   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
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   Nather A, 2010, ANN ACAD MED SINGAP, V39, P353
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NR 22
TC 13
Z9 15
U1 0
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD OCT
PY 2012
VL 33
IS 10
BP 832
EP 837
DI 10.3113/FAI.2012.0832
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 015ZL
UT WOS:000309486800004
PM 23050705
DA 2026-07-24
ER
PT J
AU Domínguez, LP
   Rivera, HP
   Alvarado, NC
   Saco, AL
   Vázquez, AR
   Núñez, EC
AF Perez Dominguez, Lucinda
   Pardellas Rivera, Hermelinda
   Caceres Alvarado, Nieves
   Lopez Saco, Angel
   Rivo Vazquez, Angel
   Casal Nunez, Enrique
TI Vacuum assisted closure in open abdomen and deferred closure: experience
   in 23 patients
SO CIRUGIA ESPANOLA
LA Spanish
DT Article
DE Laparostomy; Open abdomen; Vacuum assisted closure
ID ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION; TEMPORARY
   CLOSURE; FASCIAL CLOSURE; INTERNATIONAL-CONFERENCE; ACUTE-PANCREATITIS;
   DAMAGE-CONTROL; MANAGEMENT; WOUNDS; PRESSURE
AB Introduction: We analyse our experience and the results obtained with the use of vacuum assisted closure (VAC (R), KCI Clinic Spain SL) in the management of open abdomen.
   Material and methods: We retrospectively reviewed the laparostomies performed between June 2006 and March 2011 using VAC (R) treatment in the Hospital Xeral-Cies, Vigo.
   Results: We included 23 consecutive patients (18 males and 5 females) on whom the VAC (R) was used in the open abdomen due to different indications (abdominal trauma, peritonitis, pancreatitis, ischaemic disease or abdominal compartmental syndrome). The VAC (R) needed changing a mean of 3.1 times per patient (range 1-7), with total mean treatment duration of 14.8 days (2-43) until closure, primary closure being achieved in 18 out of 21 patients (86%). The mean hospital stay was 110.1 days (8-163) and 6 patients (26%) died during their hospital stay due to problems related to their underlying disease. Seven cases (30%) had complications during the VAC (R) therapy: 3 intra-abdominal abscesses (13%), 4 fistulas or suture dehiscence (17%), and 1 evisceration (4%).
   Conclusions: VAC (R) therapy is simple to manage, with an acceptable rate of complication, particularly of intestinal fistulas, and a reduced mortality. Of the various systems available for the deferred closure of the abdomen, the VAC (R) has made considerable progress in the past few years, mainly due to its adaptable material, and its numerous advantages. Its use will possibly increase in the future. (c) 2011 AEC. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Perez Dominguez, Lucinda; Pardellas Rivera, Hermelinda; Caceres Alvarado, Nieves; Lopez Saco, Angel; Rivo Vazquez, Angel; Casal Nunez, Enrique] Hosp Xeral Cies, Serv Cirugia Gen, Vigo, Pontevedra, Spain.
C3 Complexo Hospitalario Universitario de Vigo
RP Domínguez, LP (通讯作者)，Hosp Xeral Cies, Serv Cirugia Gen, Complexo Hosp Univ Vigo, Vigo, Pontevedra, Spain.
EM lucindaperezdominguez@hotmail.com
CR Amin AI, 2009, WORLD J GASTROENTERO, V15, P3394, DOI 10.3748/wjg.15.3394
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NR 40
TC 12
Z9 16
U1 0
U2 2
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD OCT
PY 2012
VL 90
IS 8
BP 506
EP 512
DI 10.1016/j.ciresp.2012.03.009
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 017SL
UT WOS:000309611200009
PM 22652131
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Vos, RJ
   Yilmaz, A
   Sonker, U
   Kelder, JC
   Kloppenburg, GTL
AF Vos, Roemer J.
   Yilmaz, Alaaddin
   Sonker, Uday
   Kelder, Johannes C.
   Kloppenburg, Geoffrey T. L.
TI Primary closure using Redon drains vs vacuum-assisted closure in
   post-sternotomy mediastinitis
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE VAC; Redon; Mediastinitis; Infection; Sternotomy
ID STERNAL WOUND-INFECTION; POSTSTERNOTOMY MEDIASTINITIS; POSTOPERATIVE
   MEDIASTINITIS; CONVENTIONAL TREATMENT; CARDIAC-SURGERY; RISK-FACTORS;
   MANAGEMENT; CATHETERS; THERAPY
AB Vacuum-assisted closure (VAC) is a commonly used therapy for the treatment of post-sternotomy mediastinitis. Primary closure of the sternum with high vacuum suction using Redon drains is an alternative that may reduce hospital stay. The aim of this study was to describe for the first time, the results of VAC compared with Redon drainage.
   We performed a retrospective analysis of 132 patients undergoing VAC (n = 89) or primary closure of the sternum with Redon drains (n = 43) as treatment for post-sternotomy mediastinitis between January 2000 and January 2011. Patient characteristics, risk factors and procedure-related variables were analysed. Duration of therapy, treatment failure, hospital stay and mortality as well as C-reactive protein and blood leucocyte counts on admission and at various time intervals during hospital stay were determined.
   In-hospital mortality was 12.5% in the VAC group compared with 14% in the Redon group (P = 0.96). Treatment failure in the VAC and Redon groups occurred in 28 and 23% of the patients, respectively (P = 0.68). Intensive-care stay in the VAC group was 6.8 +/- 14.4 days, and 4.8 +/- 10.1 days in the Redon group (P = 0.99). Hospitalization in the VAC group was 74 +/- 61 days and in the Redon group, 45 +/- 38 days (P = 0.0001).
   Primary closure using high vacuum suction drains is a safe and feasible treatment modality for post-sternotomy mediastinitis. It reduces hospital stay when compared with VAC therapy, without compromising mortality.
C1 [Vos, Roemer J.; Yilmaz, Alaaddin; Sonker, Uday; Kloppenburg, Geoffrey T. L.] St Antonius Hosp, Dept Cardiothorac Surg, NL-3435 CM Nieuwegein, Netherlands.
   [Kelder, Johannes C.] St Antonius Hosp, Dept Cardiol, NL-3435 CM Nieuwegein, Netherlands.
C3 St. Antonius Hospital Utrecht; St. Antonius Hospital Utrecht
RP Kloppenburg, GTL (通讯作者)，St Antonius Hosp, Dept Cardiothorac Surg, Koekoekslaan 1, NL-3435 CM Nieuwegein, Netherlands.
EM geoffrey_kloppenburg@hotmail.com
OI Vos, Roemer/0000-0002-2511-988X
CR Berg HF, 2000, ANN THORAC SURG, V70, P924, DOI 10.1016/S0003-4975(00)01524-1
   Calvat S, 1996, ANN THORAC SURG, V61, P195, DOI 10.1016/0003-4975(95)00921-3
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NR 22
TC 16
Z9 21
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD OCT
PY 2012
VL 42
IS 4
BP E53
EP E57
DI 10.1093/ejcts/ezs404
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 018TV
UT WOS:000309687000003
PM 22885227
OA Bronze
DA 2026-07-24
ER
PT J
AU Arezzo, A
   Verra, M
   Reddavid, R
   Cravero, F
   Bonino, MA
   Morino, M
AF Arezzo, Alberto
   Verra, Mauro
   Reddavid, Rossella
   Cravero, Francesca
   Bonino, Marco Augusto
   Morino, Mario
TI Efficacy of the over-the-scope clip (OTSC) for treatment of colorectal
   postsurgical leaks and fistulas
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Colorectal surgery; Postoperative complications; Anastomotic leak;
   Endoscopic clips; Over-the-scope clip
ID PERFORATIONS; CLOSURE; SURGERY
AB Colorectal postsurgical leaks and fistulas are severe complications that dramatically increase morbidity and mortality. The aim of this study was to evaluate the clinical impact of over-the-scope clip (OTSC) closure to seal the visceral wall in the management of acute and chronic colorectal postsurgical leaks and fistulas.
   We reviewed our prospective series of acute and chronic colorectal postsurgical leaks and fistulas observed between April 2008 and September 2011 and treated by OTSC. Indications were all cases with an orifice < 15 mm in maximum diameter with no extraluminal abscess and luminal stenosis.
   Endoscopic OTSC closure was performed in 14 consecutive patients (mean defect = 9.1 mm in diameter) by means of 10.5- or 12-mm clips, depending on the wall defect diameter. In eight cases, the indication was an acute leak and in six cases a chronic leak, mainly after anterior rectal resection; two cases were complicated by a rectovaginal fistula and in two other cases by a colocutaneous fistula. OTSC treatment was used to complete endoscopic vacuum-assisted closure of a large defect in three cases. The overall success rate was 86 % (12/14): 87 % (7/8) in acute and 83 % (5/6) in chronic cases. No OTSC-related complications occurred. Further surgery was required in one case.
   Endoscopic OTSC closure of colorectal postsurgical leaks and fistulas is a safe technique, with a high success rate in both acute and chronic cases, including rectovaginal and colocutaneous fistulas.
C1 [Arezzo, Alberto; Verra, Mauro; Reddavid, Rossella; Cravero, Francesca; Bonino, Marco Augusto; Morino, Mario] Univ Turin, I-10126 Turin, Italy.
C3 University of Turin
RP Arezzo, A (通讯作者)，Univ Turin, Corso Dogliotti 14, I-10126 Turin, Italy.
EM alberto.arezzo@mac.com
RI Morino, Mario/AAI-6437-2020; Reddavid, Rossella/ABD-9000-2020; Arezzo,
   Alberto/AAB-6552-2020
OI Morino, Mario/0000-0003-4540-1409; Reddavid,
   Rossella/0000-0003-0603-9953; Bonino, Marco Augusto/0000-0002-1462-5322;
   Arezzo, Alberto/0000-0002-2110-4082
CR Bonin Eduardo A, 2010, Curr Gastroenterol Rep, V12, P374, DOI 10.1007/s11894-010-0136-x
   Bruce J, 2001, BJS-BRIT J SURG, V88, P1157, DOI 10.1046/j.0007-1323.2001.01829.x
   Chambers WM, 2004, BEST PRACT RES CL GA, V18, P865, DOI 10.1016/j.bpg.2004.06.026
   Kirschniak A, 2011, SURG ENDOSC, V25, P2901, DOI 10.1007/s00464-011-1640-2
   Manta R, 2011, ENDOSCOPY, V43, P545, DOI 10.1055/s-0030-1256196
   Parodi A, 2010, GASTROINTEST ENDOSC, V72, P881, DOI 10.1016/j.gie.2010.04.006
   Raju GS, 2007, GASTROINTEST ENDOSC, V66, P774, DOI 10.1016/j.gie.2007.04.020
   Raju GS, 2004, GASTROINTEST ENDOSC, V59, P267, DOI 10.1016/S0016-5107(03)02110-2
   Schurr MO, 2008, ENDOSCOPY, V40, P584, DOI 10.1055/s-2008-1077354
   Trecca A, 2008, TECH COLOPROCTOL, V12, P315, DOI 10.1007/s10151-008-0442-6
   Voermans RP, 2011, ENDOSCOPY, V43, P217, DOI 10.1055/s-0030-1256072
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 12
TC 63
Z9 78
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
J9 SURG ENDOSC
JI Surg. Endosc.
PD NOV
PY 2012
VL 26
IS 11
BP 3330
EP 3333
DI 10.1007/s00464-012-2340-2
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 021IX
UT WOS:000309879600045
PM 22580885
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Kleif, J
   Fabricius, R
   Bertelsen, CA
   Bruun, J
   Gögenur, I
AF Kleif, Jakob
   Fabricius, Rasmus
   Bertelsen, Claus Anders
   Bruun, Jens
   Gogenur, Ismail
TI Promising results after vacuum-assisted wound closure and mesh-mediated
   fascial traction
SO DANISH MEDICAL JOURNAL
LA English
DT Article
ID TOPICAL NEGATIVE-PRESSURE; OPEN ABDOMEN; TRAUMA
AB INTRODUCTION: Patients with an open abdomen (OA) present a major challenge to the surgeon. High mortality and associated complication rates have been reported depending on the specific method of temporary abdominal closure, the primary disorder and any co-morbidity. Vacuum-assisted wound closure and mesh-mediated fascial traction (VAWCM) is a novel technique recently introduced for late fascial closure of the OA. In previous studies, the disease aetiologies were mainly vascular and visceral surgical disease and trauma. We report our results using VAWCM in a non-trauma patient population treated with an OA due to visceral surgical disease.
   MATERIAL AND METHODS: Medical records of all patients in our department treated with VAWCM during the period from 1 August 2009 to 31 May 2011 were reviewed. All sixteen patients were non-trauma patients. The initial treatment was vacuum-assisted closure (VAC) (Abdominal Dressing System KCI, San Antonio, Texas, USA). VAWCM treatment was initiated if complete fascial closure could not be obtained with VAC.
   RESULTS: Two patients died of multiple organ failure that was not associated with the VAWCM treatment. In one patient, treatment was terminated due to a very short life expectancy. We achieved a complete fascial closure rate in seven out of 16 patients. One patient had a pancreatic fistula at discharge that was not associated with the VAWCM treatment. No enteric fistulas occurred.
   CONCLUSION: It seems that VAWCM can improve the rate of complete fascial closure after treatment with OA without increasing the mortality or the occurrence of enteric fistula compared with other kinds of temporary abdominal closure.
C1 [Kleif, Jakob; Fabricius, Rasmus; Bertelsen, Claus Anders; Bruun, Jens; Gogenur, Ismail] Cent Hosp Hillerod, Kirurg Afdeling, DK-3400 Hillerod, Denmark.
RP Kleif, J (通讯作者)，Cent Hosp Hillerod, Kirurg Afdeling, DK-3400 Hillerod, Denmark.
EM kleifen@dadlnet.dk
RI ; Bertelsen, Claus Anders/AAZ-8209-2020
OI Gögenur, Ismail/0000-0002-3753-268X; Bertelsen, Claus
   Anders/0000-0001-6337-8447; Kleif, Jakob/0000-0002-9330-0410
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   [Anonymous], WORLD J SURG
   Caro A, 2011, INT WOUND J, V8, P274, DOI 10.1111/j.1742-481X.2011.00782.x
   den Hartog Dennis, 2008, Cochrane Database Syst Rev, pCD006438, DOI 10.1002/14651858.CD006438.pub2
   Diaz JJ, 2010, J TRAUMA, V68, P1425, DOI 10.1097/TA.0b013e3181da0da5
   Garner GB, 2001, AM J SURG, V182, P630, DOI 10.1016/S0002-9610(01)00786-3
   Hoyrup S, 2012, DAN MED J, V59
   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
   Oetting P, 2006, CHIRURG, V77, P586, DOI 10.1007/s00104-006-1200-9
   Perez D, 2007, J AM COLL SURGEONS, V205, P586, DOI 10.1016/j.jamcollsurg.2007.05.015
   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   Schmelzle M, 2010, DIGEST SURG, V27, P272, DOI 10.1159/000314609
   Seternes A, 2010, EUR J VASC ENDOVASC, V40, P60, DOI 10.1016/j.ejvs.2010.02.018
   Shaikh IA, 2010, COLORECTAL DIS, V12, P931, DOI 10.1111/j.1463-1318.2009.01929.x
   Stevens P, 2009, INT WOUND J, V6, P259, DOI 10.1111/j.1742-481X.2009.00614.x
   Stone PA, 2004, J TRAUMA, V57, P1082, DOI 10.1097/01.TA.0000149248.02598.9E
   Suliburk JW, 2003, J TRAUMA, V55, P1155, DOI 10.1097/01.TA.0000100218.03754.6A
   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
   Wondberg D, 2008, WORLD J SURG, V32, P2724, DOI 10.1007/s00268-008-9762-y
NR 19
TC 14
Z9 15
U1 0
U2 1
PU DANISH MEDICAL ASSOC
PI COPENHAGEN
PA TRONDHJEMSGADE 9, DK-2100 COPENHAGEN, DENMARK
EI 2245-1919
J9 DAN MED J
JI Dan. Med. J.
PD SEP
PY 2012
VL 59
IS 9
AR A4495
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 021LM
UT WOS:000309886300003
PM 22951196
DA 2026-07-24
ER
PT J
AU Sjögren, J
   Gustafsson, R
   Nilsson, J
   Lindstedt, S
   Nozohoor, S
   Ingemansson, R
AF Sjogren, Johan
   Gustafsson, Ronny
   Nilsson, Johan
   Lindstedt, Sandra
   Nozohoor, Shahab
   Ingemansson, Richard
TI Negative-pressure wound therapy following cardiac surgery: bleeding
   complications and 30-day mortality in 176 patients with deep sternal
   wound infection
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Wound infection; Sternum; Negative-pressure wound therapy; Outcome
ID RIGHT-VENTRICULAR RUPTURE; VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY
   MEDIASTINITIS; POSTOPERATIVE MEDIASTINITIS; CONVENTIONAL TREATMENT
AB Negative-pressure wound therapy (NPWT) has been used for the treatment of deep sternal wound infection (DSWI) with promising results. However, questions have been raised regarding the potential risk of right ventricle (RV) rupture during treatment. In the present study, we evaluate our clinical experience of NPWT focusing on RV rupture and major bleeding complications and its potentially negative impact on 30-day mortality during an 11-year period. Serious bleeding complications during NPWT were reviewed for 176 patients treated for DSWI between January 1999 and April 2010. The 30-day mortality following DSWI was 1.1% (2/176). Four patients (2.3%) suffered bleeding from the RV rupture during NPWT of the sternal wound (two spontaneous and two debridement related). Furthermore, two patients had debridement-related bleedings from the venous bypass grafts during wound dressing change. The very low 30-day mortality (1.1%) following DSWI supports the use of NPWT. Overall, even if major bleeding complications may occur, the risk of RV rupture seems to be outweighed by the benefit of superior infection control. However, surgical experience is recommended when debriding sternal wounds and we recommend the use of a wound dressing, such as paraffin gauze, in order to protect the RV from direct contact with the polyurethane foam. (C) 2011 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Sjogren, Johan; Gustafsson, Ronny; Nilsson, Johan; Lindstedt, Sandra; Nozohoor, Shahab; Ingemansson, Richard] Lund Univ, Univ Lund Hosp, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital
RP Sjögren, J (通讯作者)，Lund Univ, Univ Lund Hosp, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM johan.sjogren@med.lu.se
RI Nilsson, Johan/A-4742-2011; Lindstedt, Sandra/AEM-2892-2022; Sjögren,
   Johan/AAZ-6448-2021
OI Nilsson, Johan/0000-0001-6860-6090; Lindstedt,
   Sandra/0000-0003-4484-6473; Ingemansson, Richard/0000-0001-7623-8953; 
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
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   Ennker IC, 2009, J CARDIOTHORAC SURG, V4, DOI 10.1186/1749-8090-4-5
   Erwin F, 2010, INTERACT CARDIOV TH, V10, P472
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   Lu JCY, 2003, EUR J CARDIO-THORAC, V23, P943, DOI 10.1016/S1010-7940(03)00137-4
   Niclauss L, 2010, INTERACT CARDIOV TH, V10, P470, DOI 10.1510/icvts.2009.223891
   Petzina R, 2010, EUR J CARDIO-THORAC, V38, P110, DOI 10.1016/j.ejcts.2010.01.028
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Yellin A, 2003, J THORAC CARDIOV SUR, V125, P554, DOI 10.1067/mtc.2003.31
NR 15
TC 45
Z9 51
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD FEB
PY 2011
VL 12
IS 2
BP 117
EP 120
DI 10.1510/icvts.2010.252668
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 022BR
UT WOS:000309930500006
PM 21106567
OA Bronze
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Lindstedt, S
   Ingemansson, R
AF Malmsjo, Malin
   Lindstedt, Sandra
   Ingemansson, Richard
TI Effects of foam or gauze on sternum wound contraction, distension and
   heart and lung damage during negative-pressure wound therapy of porcine
   sternotomy wounds
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Animal model; Wound contraction; Experimental surgery; Heart rupture;
   Negative-pressure wound therapy; Sternotomy wound
ID VACUUM-ASSISTED CLOSURE; VENTRICULAR RUPTURE; TRANSDUCTION
AB The study was performed to compare the effects of negative-pressure wound therapy (NPWT) using gauze and foam on wound edge movement and the macroscopic appearance of the heart and lungs after NPWT. Sternotomy wounds were created in 6x70 kg pigs. Negative pressures of -40, -70, -120 and -160 mmHg were applied and the following were evaluated: wound contraction, distension and the macroscopic appearance of the heart and lungs after NPWT. Wound contraction was greater when using foam than gauze (3.5+/-0.3 cm and 1.3+/-0.2 cm, respectively, P<0.01). The application of traction to the lateral edges of the sternotomy resulted in greater wound distention with foam than with gauze (5.3+/-0.3 cm and 3.6+/-0.2 cm, respectively, P<0.001). After using foam, the surface of the heart was red and mottled, and lung emphysema and sometimes, lung rupture were observed. After using gauze, the organ surface had no markings. The study shows that foam allows greater wound contraction and distension than gauze. This movement of the wound edges may cause damage to the underlying organs. There is less damage to the heart and lungs when using gauze than foam. (C) 2011 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden.
   [Lindstedt, Sandra; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Maljö, Malin/0000-0001-9849-9599;
   Ingemansson, Richard/0000-0001-7623-8953
FU Ake-Wieberg Foundation; Magn Bergvall Foundation; Swedish Medical
   Association; Royal Physiographic Society in Lund; Crafoord Foundation;
   Swedish Heart-Lung Foundation; Swedish Hypertension Society; Smith &
   Nephew Wound Management
FX This study was funded by the Ake-Wieberg Foundation, the Magn Bergvall
   Foundation, the Swedish Medical Association, the Royal Physiographic
   Society in Lund, the Crafoord Foundation, the Swedish Heart-Lung
   Foundation, the Swedish Hypertension Society and Smith & Nephew Wound
   Management.
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
   Borgquist O, 2009, WOUNDS, V21, P302
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   FDA PPHN, 2009, SER COMPL ASS NEG PR
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Jeffery LC, 2009, EPLASTY, V9, pe28
   Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   Malmsjö M, 2009, WOUND REPAIR REGEN, V17, P200, DOI 10.1111/j.1524-475X.2009.00461.x
   Malmsjö M, 2009, J THORAC CARDIOV SUR, V138, P712, DOI 10.1016/j.jtcvs.2008.11.068
   Mokhtari A, 2006, ANN THORAC SURG, V82, P1063, DOI 10.1016/j.athoracsur.2006.04.085
   Paglinawan R, 2008, COMP STUDY INFLUENCE
   Sartipy U, 2008, SINGAP MED J, V49, pE134
   Sjögren J, 2003, ANN THORAC SURG, V75, P1311, DOI 10.1016/S0003-4975(02)04570-8
   Torbrand C, 2008, INT WOUND J, V5, P579, DOI 10.1111/j.1742-481X.2007.00425.x
NR 15
TC 10
Z9 13
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD MAR
PY 2011
VL 12
IS 3
BP 349
EP 354
DI 10.1510/icvts.2010.249078
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 022VM
UT WOS:000309991900003
PM 21186283
OA Bronze
DA 2026-07-24
ER
PT J
AU Berdajs, DA
   Trampuz, A
   Ferrari, E
   Ruchat, P
   Hurni, M
   von Segesser, LK
AF Berdajs, Denis A.
   Trampuz, Andrej
   Ferrari, Enrico
   Ruchat, Patrick
   Hurni, Michel
   von Segesser, Ludwig K.
TI Delayed primary versus late secondary wound closure in the treatment of
   postsurgical sternum osteomyelitis
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Surgical site infections; Mediastinitis; Poststernotomy infection;
   Surgical complications
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; RISK-FACTORS; POSTOPERATIVE
   MEDIASTINITIS; SURGERY; INFECTION
AB Sternal osteomyelitis and poststernotomy mediastinitis is a severe and life-threatening complication after the cardiac surgery. The incidence ranges up to 3% with a mortality rate up to 29%. In addition, postoperative infections after sternotomy are associated with prolonged hospital stay, increased healthcare costs and impaired quality of patient life, representing an economic and social burden. The emergence of increasing antimicrobial resistant bacteria augments the importance of postsurgical infections since the antimicrobial choices are becoming limited. Furthermore, the incidence of infection is an indicator for the quality of patient care in the international benchmark studies. Although several therapy strategies are nowadays present in clinical practice, there is a lack of evidence-based surgical consensus for treatment of this surgical complication. In most cases the poststernotomy mediastinitis involves surgical revision with debridement, open dressing and/or vacuum-assisted therapy. After the granulation tissue on open chest wound is achieved, secondary closure andyor reconstruction with vascularized soft tissue flaps, such as omentum or pectoral muscle is performed. It seems there is a need for more effective surgical treatment of poststernotomy wound infections, which may address the prolonged hospitalization and reduce the number of surgical interventions and with this also the perioperative morbidity. In light of this we propose a randomized study comparing new delayed primary closure of the sternum to the secondary vacuum-assisted closure. (C) 2011 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Berdajs, Denis A.; Ferrari, Enrico; Ruchat, Patrick; Hurni, Michel; von Segesser, Ludwig K.] CHU Vaudois, Dept Cardiovasc Surg, CH-1011 Lausanne, Switzerland.
   [Trampuz, Andrej] CHU Vaudois, Dept Infect Dis, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Berdajs, DA (通讯作者)，CHU Vaudois, Dept Cardiovasc Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM denis.berdajs@chuv.ch
RI Berdajs, Denis/AAG-8268-2021; /AAD-2897-2020
OI Berdajs, Denis/0000-0003-0478-903X; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Gårdlund B, 2002, EUR J CARDIO-THORAC, V21, P825, DOI 10.1016/S1010-7940(02)00084-2
   KRABATSCH T, 1995, J CARDIAC SURG, V10, P637, DOI 10.1111/j.1540-8191.1995.tb00654.x
   LOOP FD, 1990, ANN THORAC SURG, V49, P179, DOI 10.1016/0003-4975(90)90136-T
   Lu JCY, 2003, EUR J CARDIO-THORAC, V23, P943, DOI 10.1016/S1010-7940(03)00137-4
   Mangram AJ, 1999, AM J INFECT CONTROL, V27, P97, DOI 10.1016/S0196-6553(99)70088-X
   MILANO CA, 1995, CIRCULATION, V92, P2245, DOI 10.1161/01.CIR.92.8.2245
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   WOUTERS R, 1994, TEX HEART I J, V21, P183
NR 11
TC 15
Z9 18
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUN
PY 2011
VL 12
IS 6
BP 914
EP 918
DI 10.1510/icvts.2010.263483
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 022XH
UT WOS:000309997000007
PM 21372144
OA Bronze
DA 2026-07-24
ER
PT J
AU Haghshenasskashani, A
   Rahnavardi, M
   Yan, TD
   McCaughan, BC
AF Haghshenasskashani, Alireza
   Rahnavardi, Mohammad
   Yan, Tristan D.
   McCaughan, Brian C.
TI Intrathoracic application of a vacuum-assisted closure device in
   managing pleural space infection after lung resection: is it an option?
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Pleural space infection; Vacuum-assisted closure; Empyema; Lung
   resection
ID OPEN WINDOW THORACOSTOMY; POSTPNEUMONECTOMY EMPYEMA; MANAGEMENT; THERAPY
AB Empyema after lung resection is a challenging condition to manage and is associated with a high mortality. Intrathoracic application of a vacuum-assisted closure (VAC) device is recently introduced as an adjunct in the management of this condition. A best evidence topic was constructed to address whether this approach is effective in successful chest closure and reducing hospital stay. Twenty-three papers were found using the reported search, of which nine papers were identified that provided the best evidence to answer the question. All papers were retrospective and included a total of 69 patients treated with intrathoracic VAC. There was only one cohort study and the rest were either case series or case reports. In a cohort of 19 patients reported by Palmen et al. the average duration of an open window thoracostomy in a group of patients with VAC (n = 11) was 39 +/- 17 days and in those without VAC (n = 8) was 933 +/- 1422 days. Median length of VAC treatment was 22 days (range 6-66 days) in a series of 28 patients reported by Saadi et al. Some authors excluded patients with a bronchopleural fistula (BPF) from VAC treatment. However, Groetzner et al. have safely used VAC in patients with BPF after covering the bronchus stump with an intrathoracic muscle flap. The mediastinum and the bronchus can be covered using a polyvinyl-alcohol foam. Polyurethane foam is commonly used to fill the intrathoracic cavity up to the superficial wound. The suggested starting level of negative pressure is as low as -25 mmHg to -75 mmHg depending on the presence or absence of signs of mediastinal traction; this negative pressure can gradually be increased to -125 mmHg over time. The recommended interval between VAC changes is two to five days. Accumulated evidence in this article, although limited, suggests that VAC, as an adjunct to the standard treatment, can potentially alleviate the morbidity and decrease hospital stay in patients with empyema after lung resection. VAC can reduce inpatient length of treatment and can make the condition manageable in an outpatient setting. These results are yet to be proven by larger studies and clinical trials. (C) 2011 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Haghshenasskashani, Alireza; Rahnavardi, Mohammad; Yan, Tristan D.; McCaughan, Brian C.] Univ Sydney, Royal Prince Alfred Hosp, Dept Cardiothorac Surg, Sydney, NSW 2006, Australia.
   [Haghshenasskashani, Alireza; Rahnavardi, Mohammad; Yan, Tristan D.; McCaughan, Brian C.] Baird Inst Appl Heart & Lung Surg Res, Sydney, NSW, Australia.
C3 University of Sydney; NSW Health; Royal Prince Alfred Hospital
RP Rahnavardi, M (通讯作者)，Univ Sydney, Royal Prince Alfred Hosp, Dept Cardiothorac Surg, Sydney, NSW 2006, Australia.
EM rahnavardi@gmail.com
OI Yan, Tristan/0000-0002-7473-1522
CR Al-Mufarrej F, 2010, SURG TODAY, V40, P711, DOI 10.1007/s00595-008-4096-9
   [Anonymous], 17 EUR C GEN THOR SU
   Aru GM, 2010, ANN THORAC SURG, V90, P266, DOI 10.1016/j.athoracsur.2010.04.092
   Ben-Nun A, 2003, Interact Cardiovasc Thorac Surg, V2, P616, DOI 10.1016/S1569-9293(03)00149-X
   CLAGETT OT, 1963, J THORAC CARDIOV SUR, V45, P141, DOI 10.1016/S0022-5223(19)32877-6
   Ditterich D, 2006, ZBL CHIR, V131, pS133, DOI 10.1055/s-2006-921499
   Dunning Joel, 2003, Interact Cardiovasc Thorac Surg, V2, P405, DOI 10.1016/S1569-9293(03)00191-9
   Gharagozloo Farid, 2006, Thorac Surg Clin, V16, P215, DOI 10.1016/j.thorsurg.2006.05.012
   Groetzner J, 2009, THORAC CARDIOV SURG, V57, P417, DOI 10.1055/s-0029-1185907
   Matzi V, 2007, ANN THORAC SURG, V84, P1762, DOI 10.1016/j.athoracsur.2007.05.052
   Okuda Masaya, 2009, Interact Cardiovasc Thorac Surg, V9, P916, DOI 10.1510/icvts.2009.212308
   Palmen M, 2009, ANN THORAC SURG, V88, P1131, DOI 10.1016/j.athoracsur.2009.06.030
   Renner C, 2010, ANN THORAC SURG, V89, P603, DOI 10.1016/j.athoracsur.2009.06.037
   SHAMJI FM, 1983, J THORAC CARDIOV SUR, V86, P818
   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
   Widmer MK, 2000, EUR J CARDIO-THORAC, V18, P435, DOI 10.1016/S1010-7940(00)00538-8
NR 16
TC 22
Z9 26
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD AUG
PY 2011
VL 13
IS 2
BP 168
EP 174
DI 10.1510/icvts.2011.267286
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 024YD
UT WOS:000310146800013
PM 21602420
OA Bronze
DA 2026-07-24
ER
PT J
AU Suzuki, R
   Mikamo, A
   Kurazumi, H
   Hamano, K
AF Suzuki, Ryo
   Mikamo, Akihito
   Kurazumi, Hiroshi
   Hamano, Kimikazu
TI Delayed sternal closure after vacuum-assisted closure therapy for
   tracheo-innominate artery fistula repair
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Tracheo-innominate artery fistula; Tracheostomy; Vacuum-assisted closure
   therapy
ID MANAGEMENT
AB We report a case of successful innominate artery resection with delayed sternal closure after vacuum-assisted closure (VAC) therapy for a tracheo-innominate artery fistula (TIF). A 42-year-old woman with cerebral palsy underwent tracheostomy for respiratory assistance. On postoperative day 14, she was transferred to our hospital after an episode of massive hemoptysis. TIF was diagnosed based on the findings of multidetector computed tomography. Thus, we resected the innominate artery and started VAC therapy to control the postoperative local infection. The patient recovered uneventfully, without any infectious sequelae. Our strategy, which includes VAC therapy, for TIF repair may eliminate postoperative infective problems that could induce sequential bleeding and sternal compromise. To our knowledge, this is the first report of using VAC therapy for TIF. (C) 2011 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Suzuki, Ryo; Mikamo, Akihito; Kurazumi, Hiroshi; Hamano, Kimikazu] Yamaguchi Univ, Grad Sch Med, Dept Surg & Clin Sci, Div Cardiac Surg, Ube, Yamaguchi 7558505, Japan.
C3 Yamaguchi University
RP Mikamo, A (通讯作者)，Yamaguchi Univ, Grad Sch Med, Dept Surg & Clin Sci, Div Cardiac Surg, 1-1-1 Minami Kogushi, Ube, Yamaguchi 7558505, Japan.
EM mikamo@yamaguchi-u.ac.jp
FU Grants-in-Aid for Scientific Research [22591543] Funding Source: KAKEN
CR ABURAHMA AF, 1992, SURGERY, V112, P84
   ALFARO J, 1993, EUR J CARDIO-THORAC, V7, P615, DOI 10.1016/1010-7940(93)90250-F
   Black MD, 1996, ANN THORAC SURG, V62, P286, DOI 10.1016/0003-4975(96)00178-6
   Gasparri MG, 2004, ANN THORAC SURG, V77, P1424, DOI 10.1016/S0003-4975(03)01000-2
   GELMAN JJ, 1994, J AM COLL SURGEONS, V179, P626
   JONES JW, 1976, ANN SURG, V184, P194, DOI 10.1097/00000658-197608000-00011
   NUNN DB, 1975, ANN THORAC SURG, V20, P698, DOI 10.1016/S0003-4975(10)65764-5
   RAMESH M, 1978, J THORAC CARDIOV SUR, V75, P138
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NR 10
TC 2
Z9 2
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD AUG
PY 2011
VL 13
IS 2
BP 229
EP 231
DI 10.1510/icvts.2011.269985
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 024YD
UT WOS:000310146800034
PM 21628318
OA Bronze
DA 2026-07-24
ER
PT J
AU Vos, RJ
   Yilmaz, A
   Sonker, U
   Kelder, JC
   Kloppenburg, GTL
AF Vos, Roemer J.
   Yilmaz, Alaaddin
   Sonker, Uday
   Kelder, Johannes C.
   Kloppenburg, Geoffrey T. L.
TI Vacuum-assisted closure of post-sternotomy mediastinitis as compared to
   open packing
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Vacuum-assisted closure; Mediastinitis; Infection; Sternotomy
ID STERNAL WOUND-INFECTION; POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS;
   POSTOPERATIVE MEDIASTINITIS; THERAPY; SURVIVAL; SURGERY
AB Post-sternotomy mediastinitis is a rare but serious complication of cardiac surgery leading to prolonged hospital stay and higher mortality. In the last decades several treatment modalities have been described, of which vacuum-assisted closure (VAC) shows the most promising results. The aim of this study is to describe clinical outcomes of VAC as compared to open packing and to predict risk factors for mortality. We performed a retrospective analysis of 113 patients with mediastinitis undergoing VAC (n = 89) or open packing (n = 24) between January 2000 and July 2010. Patient characteristics, risk factors and procedure-related variables were analysed. C-reactive protein and leukocyte counts were determined on admission and at regular intervals during hospital stay. We compared length of treatment, treatment failure, hospital stay and mortality. We also analysed risk factors predicting mortality. In-hospital mortality in the VAC group was 12.4% compared to 41.7% in the conventional group (P = 0.0032). Intensive care stay was 6.8 +/- 14.4 days with VAC therapy compared to 18.5 +/- 21.0 days with open packing (P = 0.0081). Significant risk factors for mortality were pre-operative renal failure and obesity. Our findings indicate that VAC therapy is superior to open packing, resulting in shorter intensive care stay and improved survival.
C1 [Vos, Roemer J.; Yilmaz, Alaaddin; Sonker, Uday; Kloppenburg, Geoffrey T. L.] St Antonius Hosp, Dept Cardiothorac Surg, Nieuwegein, Netherlands.
   [Kelder, Johannes C.] St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.
C3 St. Antonius Hospital Utrecht; St. Antonius Hospital Utrecht
RP Kloppenburg, GTL (通讯作者)，St Antonius Hosp, Dept Cardiothorac Surg, Nieuwegein, Netherlands.
EM geoffrey_kloppenburg@hotmail.com
OI Vos, Roemer/0000-0002-2511-988X
CR Davydov Iu A, 1992, Khirurgiia (Mosk), P21
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Ennker IC, 2011, THORAC CARDIOV SURG, V59, P15, DOI 10.1055/s-0030-1250335
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Fuchs U, 2005, ANN THORAC SURG, V79, P526, DOI 10.1016/j.athoracsur.2004.08.032
   HORAN TC, 1992, AM J INFECT CONTROL, V20, P271, DOI 10.1016/S0196-6553(05)80201-9
   Karra R, 2006, J THORAC CARDIOV SUR, V132, P537, DOI 10.1016/j.jtcvs.2006.04.037
   Lu JCY, 2003, EUR J CARDIO-THORAC, V23, P943, DOI 10.1016/S1010-7940(03)00137-4
   Mokhtari A, 2008, SCAND CARDIOVASC J, V42, P85, DOI 10.1080/14017430701744469
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Risnes I, 2010, ANN THORAC SURG, V89, P1502, DOI 10.1016/j.athoracsur.2010.02.038
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Tomos P, 2006, ANN THORAC SURG, V81, P754, DOI 10.1016/j.athoracsur.2004.10.065
NR 15
TC 37
Z9 46
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JAN
PY 2012
VL 14
IS 1
BP 17
EP 20
DI 10.1093/icvts/ivr049
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 025GD
UT WOS:000310174000005
PM 22108946
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Osada, H
   Nakajima, H
   Morishima, M
   Su, T
AF Osada, Hiroaki
   Nakajima, Hiroyuki
   Morishima, Manabu
   Su, Takamitsu
TI Candidal mediastinitis successfully treated using vacuum-assisted
   closure following open-heart surgery
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Antibiotics; Mediastinal infection; Postoperative care; Candidal
   infection; Surgical site infection
ID STERNAL WOUND-INFECTION; POST-STERNOTOMY MEDIASTINITIS; LONG-TERM
   SURVIVAL; THERAPY
AB Deep sternal wound infections (DSWIs) are an uncommon but serious complication after open-heart surgery. The reported incidence of DSWIs due to Candida albicans is 0.4%, but these infections have an extremely high mortality of 56%. We herein report a rare case of a 79-year old woman who suffered from Candidal DSWI after repeated open-heart surgeries. We treated her with negative pressure wound therapy (NPWT). This is the rare case report that provides evidence that NPWT is a safe and suitable technique for the management of Candidal DSWIs.
C1 [Osada, Hiroaki] Mitsubishi Kyoto Hosp, Dept Cardiovasc Surg, Nishikyo Ku, Kyoto 6158087, Japan.
RP Osada, H (通讯作者)，Mitsubishi Kyoto Hosp, Dept Cardiovasc Surg, Nishikyo Ku, 1 Katsuragoshomachi, Kyoto 6158087, Japan.
EM osahiro@kuhp.kyoto-u.ac.jp
RI /HPF-4944-2023
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Clancy CJ, 1997, CLIN INFECT DIS, V25, P608, DOI 10.1086/513770
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Malani PN, 2002, CLIN INFECT DIS, V35, P1316, DOI 10.1086/344192
   Modrau IS, 2009, ANN THORAC SURG, V88, P1905, DOI 10.1016/j.athoracsur.2009.08.012
   Petzina R, 2010, EUR J CARDIO-THORAC, V38, P110, DOI 10.1016/j.ejcts.2010.01.028
   Risnes I, 2010, ANN THORAC SURG, V89, P1502, DOI 10.1016/j.athoracsur.2010.02.038
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   Tocco MP, 2009, EUR J CARDIO-THORAC, V35, P833, DOI 10.1016/j.ejcts.2008.12.036
NR 9
TC 7
Z9 9
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUN
PY 2012
VL 14
IS 6
BP 872
EP 874
DI 10.1093/icvts/ivs084
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 025GK
UT WOS:000310175300052
PM 22422875
OA Bronze
DA 2026-07-24
ER
PT J
AU Steingrimsson, S
   Gottfredsson, M
   Gudmundsdottir, I
   Sjögren, J
   Gudbjartsson, T
AF Steingrimsson, Steinn
   Gottfredsson, Magnus
   Gudmundsdottir, Ingibjorg
   Sjogren, Johan
   Gudbjartsson, Tomas
TI Negative-pressure wound therapy for deep sternal wound infections
   reduces the rate of surgical interventions for early re-infections
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Deep sternal wound infection (DSWI); Mediastinitis; Cardiac surgery;
   Negative-pressure wound therapy; Outcome; Re-infection
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   CONVENTIONAL TREATMENT; ICELAND; IMPACT
AB OBJECTIVES: To evaluate the outcome of treatment for deep sternal wound infection (DSWI) in a nationwide patient cohort, before and after the introduction of negative-pressure wound therapy (NPWT).
   METHODS: This was a population-based cohort of all patients treated for DSWI in Iceland out of 2446 open heart operations performed between 2000 and 2010. Length of hospital stay, survival and reoperations were compared in (i) 23 patients treated with open and/or closed irrigation before August 2005 (conventional treatment, CvT group) and in (ii) 20 patients treated after this time with NPWT as a first-line therapy (NPWT group).
   RESULTS: The DSWI rate was 1.8% and did not change during the study period. Demographics were similar for both groups, except for peripheral arterial disease which was less common in the NPWT group. Coagulase-negative staphylococci were also more common (as the only pathogen identified) in the NPWT group (70% vs 30%, P = 0.01). The median length of hospital stay was 43 days in both groups and the sternum could be closed with delayed primary closure in all except 2 patients, one in each group. Eight patients in the CvT group required surgical revision for re-infections, including debridement and rewiring, when compared with 1 patient in the NPWT group (P = 0.02). Furthermore, 6 patients in the CvT group developed late chronic infections of the sternum requiring surgical revision, compared with one in the NPWT group (P = 0.10). The 30-day mortality was not significantly different between groups (4% vs 0%, P > 0.1) and the same was true for 1-year mortality (17% vs 0%, P = 0.11).
   CONCLUSIONS: NPWT significantly reduces the risk of early re-infections in patients with DSWI. There was a lower rate of late chronic sternal infections and lower mortality in the NPWT group, but the difference was not statistically significant. We conclude that NPWT should be considered as a first-line treatment for most DSWIs.
C1 [Steingrimsson, Steinn; Gudbjartsson, Tomas] Landspitali Univ Hosp, Dept Cardiothorac Surg, IS-101 Reykjavik, Iceland.
   [Steingrimsson, Steinn; Gottfredsson, Magnus; Gudbjartsson, Tomas] Univ Iceland, Fac Med, Reykjavik, Iceland.
   [Gottfredsson, Magnus] Landspitali Univ Hosp, Dept Infect Dis, IS-101 Reykjavik, Iceland.
   [Gudmundsdottir, Ingibjorg] Landspitali Univ Hosp, Dept Vasc Surg, IS-101 Reykjavik, Iceland.
   [Sjogren, Johan] Lund Univ, Skane Univ Hosp, Dept Cardiothorac Surg, Lund, Sweden.
C3 Landspitali National University Hospital; University of Iceland;
   Landspitali National University Hospital; Landspitali National
   University Hospital; Lund University; Skane University Hospital
RP Gudbjartsson, T (通讯作者)，Landspitali Univ Hosp, Dept Cardiothorac Surg, IS-101 Reykjavik, Iceland.
EM tomasgud@landspitali.is
RI Steingrimsson, Steinn/AAF-5475-2021; Gottfredsson, Magnus/AAD-9086-2020;
   Sjögren, Johan/AAZ-6448-2021
OI Steingrimsson, Steinn/0000-0001-8320-5607; Gottfredsson,
   Magnus/0000-0003-2465-0422; 
FU Landspitali University Research Foundation
FX This study was supported by grants from the Landspitali University
   Research Foundation.
CR Assmann A, 2011, THORAC CARDIOV SURG, V59, P25, DOI 10.1055/s-0030-1250598
   Baillot R, 2010, EUR J CARDIO-THORAC, V37, P880, DOI 10.1016/j.ejcts.2009.09.023
   Bapat V, 2008, J CARDIAC SURG, V23, P227, DOI 10.1111/j.1540-8191.2008.00595.x
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Graf K, 2010, EUR J CARDIO-THORAC, V37, P893, DOI 10.1016/j.ejcts.2009.10.005
   Holzknecht BJ, 2010, J CLIN MICROBIOL, V48, P4221, DOI 10.1128/JCM.01382-10
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   Jidéus L, 2009, SCAND CARDIOVASC J, V43, P194, DOI 10.1080/14017430802573098
   Petzina R, 2010, EUR J CARDIO-THORAC, V38, P110, DOI 10.1016/j.ejcts.2010.01.028
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   Sjögren J, 2011, INTERACT CARDIOV TH, V12, P117, DOI 10.1510/icvts.2010.252668
   Steingrimsson S, 2008, SCAND CARDIOVASC J, V42, P208, DOI 10.1080/14017430801919557
   Steingrímsson S, 2009, ANN THORAC SURG, V88, P1910, DOI 10.1016/j.athoracsur.2009.07.012
NR 14
TC 53
Z9 69
U1 1
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD SEP
PY 2012
VL 15
IS 3
BP 406
EP 410
DI 10.1093/icvts/ivs254
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 025GN
UT WOS:000310175900016
PM 22691377
OA Bronze
DA 2026-07-24
ER
PT J
AU Cioffi, KM
   Schmiedt, CW
   Cornell, KK
   Radlinsky, MG
AF Cioffi, Krista M.
   Schmiedt, Chad W.
   Cornell, Karen K.
   Radlinsky, MaryAnn G.
TI Retrospective evaluation of vacuum-assisted peritoneal drainage for the
   treatment of septic peritonitis in dogs and cats: 8 cases (2003-2010)
SO JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
LA English
DT Article
DE cat; dog; sepsis; septic abdomen; vacuum-assisted closure; VAPD
ID GENERALIZED PERITONITIS; ABDOMINAL DRAINAGE; WOUND CONTROL; CLOSURE;
   EXPERIENCE
AB Objective - To describe the use of vacuum-assisted peritoneal drainage (VAPD) in dogs and cats with septic peritonitis.
   Design - Retrospective descriptive study.
   Setting - University Veterinary Teaching Hospital.
   Animals - Six dogs and 2 cats with septic peritonitis.
   Interventions - Application of VAPD after abdominal exploration.
   Measurements - Pre- and post-operative physical and clinicopathologic data, surgical findings, treatment, VAPD fluid production, outcome, and survival are reported.
   Main results - Eight nonconsecutive cases of septic peritonitis, consisting of 6 dogs and 2 cats, were treated surgically and had VAPD applied post-operatively. The mean duration of clinical signs prior to surgical intervention was 4 +/- 3 days. VAPD therapy was applied for a mean of 2 +/- 1.1 days and collected a median of 27 mL/kg/d of abdominal effusate. The median time in hospital was 5 days and abdominal closure was completed in 5 of the 8 patients. All specimens collected at surgery cultured positive for bacteria, most commonly Enterococcus spp. The peritoneum of 4 animals was cultured at the time of abdominal closure; 1 was negative and 3 were positive for Escherichia coli, Enterococcus spp. or gram-positive cocci. Cultures before and after surgery differed in 2 patients. Hypoproteinemia was present in all patients postoperatively. Three patients were considered survivors, all of which were dogs. Five patients died or were euthanized due to cardiopulmonary arrest (n = 3), pyothorax (n = 1), and acute, severe, septic peritonitis (n = 1).
   Conclusions - VAPD is available for maintaining abdominal drainage for the treatment of septic peritonitis after surgical intervention; however, similar to open abdominal drainage and closed suction drainage, nosocomial infection and hypoproteinemia remain challenges in the treatment of septic peritonitis.
C1 [Cioffi, Krista M.; Schmiedt, Chad W.; Cornell, Karen K.; Radlinsky, MaryAnn G.] Univ Georgia, Dept Small Anim Surg, Vet Teaching Hosp, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia
RP Radlinsky, MG (通讯作者)，Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg, Athens, GA 30605 USA.
EM radlinsk@uga.edu
RI ; Schmiedt, Chad/AEV-2703-2022
OI Cornell, Karen/0000-0002-3586-0559; Schmiedt, Chad/0000-0003-1561-0736
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Barker DE, 2007, J AM COLL SURGEONS, V204, P784, DOI 10.1016/j.jamcollsurg.2006.12.039
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   Culp WTN, 2009, SMALL ANIMAL CRITICA, P667
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NR 26
TC 25
Z9 28
U1 0
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1479-3261
EI 1476-4431
J9 J VET EMERG CRIT CAR
JI J. Vet. Emerg. Crit. Care
PD OCT
PY 2012
VL 22
IS 5
BP 601
EP 609
DI 10.1111/j.1476-4431.2012.00791.x
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 030CK
UT WOS:000310545300013
PM 22931241
DA 2026-07-24
ER
PT J
AU Bloemen, MCT
   van der Wal, MBA
   Verhaegen, PDHM
   Nieuwenhuis, MK
   van Baar, ME
   van Zuijlen, PPM
   Middelkoop, E
AF Bloemen, Monica C. T.
   van der Wal, Martijn B. A.
   Verhaegen, Pauline D. H. M.
   Nieuwenhuis, Marianne K.
   van Baar, Margriet E.
   van Zuijlen, Paul P. M.
   Middelkoop, Esther
TI Clinical effectiveness of dermal substitution in burns by topical
   negative pressure: A multicenter randomized controlled trial
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; RECONSTRUCTIVE SURGERY;
   SUBJECTIVE EVALUATION; WOUND THERAPY; FOLLOW-UP; DEVICE; SURVIVAL;
   INTEGRA; RELIABILITY
AB Previous research has shown clinical effectiveness of dermal substitution; however, in burn wounds, only limited effect has been shown. A problem in burn wounds is the reduced take of the autograft, when the substitute and graft are applied in one procedure. Recently, application of topical negative pressure (TNP) was shown to improve graft take. The aim of this study was to investigate if application of a dermal substitute in combination with TNP improves scar quality after burns. In a four-armed multicenter randomized controlled trial, a split-skin graft with or without a dermal substitute and with or without TNP was compared in patients with deep dermal or full-thickness burns requiring skin transplantation. Graft take and rate of wound epithelialization were evaluated. Three and 12 months postoperatively, scar parameters were measured. The results of 86 patients showed that graft take and epithelialization did not reveal significant differences. Significantly fewer wounds in the TNP group showed postoperative contamination, compared to other groups. Highest elasticity was measured in scars treated with the substitute and TNP, which was significantly better compared to scars treated with the substitute alone. Concluding, this randomized controlled trial shows the effectiveness of dermal substitution combined with TNP in burns, based on extensive wound and scar measurements.
C1 [Bloemen, Monica C. T.; van der Wal, Martijn B. A.; Verhaegen, Pauline D. H. M.; Nieuwenhuis, Marianne K.; van Baar, Margriet E.; van Zuijlen, Paul P. M.; Middelkoop, Esther] Assoc Dutch Burn Ctr, NL-1940 EA Beverwijk, Netherlands.
   [Bloemen, Monica C. T.; van der Wal, Martijn B. A.; Verhaegen, Pauline D. H. M.; van Zuijlen, Paul P. M.; Middelkoop, Esther] Red Cross Hosp, Burn Ctr, Beverwijk, Netherlands.
   [van der Wal, Martijn B. A.; van Zuijlen, Paul P. M.; Middelkoop, Esther] Vrije Univ Amsterdam, Med Ctr, Dept Plast Reconstruct & Hand Surg, Amsterdam, Netherlands.
   [Verhaegen, Pauline D. H. M.; van Zuijlen, Paul P. M.] Red Cross Hosp, Dept Plast Reconstruct & Hand Surg, Beverwijk, Netherlands.
   [Nieuwenhuis, Marianne K.] Martini Hosp, Burn Ctr, Groningen, Netherlands.
   [van Baar, Margriet E.] Maasstad Hosp, Burn Ctr, Rotterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Martini Hospital; Maasstad Hospital
RP Middelkoop, E (通讯作者)，Assoc Dutch Burn Ctr, Postbus 1015, NL-1940 EA Beverwijk, Netherlands.
EM e.middelkoop@vumc.nl
RI van Zuijlen, Paul/AAE-4670-2020; Middelkoop, Esther/M-3735-2014;
   nieuwenhuis, marianne/HJA-0658-2022; van Baar, Margriet/AAG-4219-2021
OI van Zuijlen, Paul/0000-0003-3461-8848; Middelkoop,
   Esther/0000-0001-8843-1080; nieuwenhuis, marianne/0000-0001-5632-3333; 
FU Dutch Burns Foundation [07.109]
FX This research was supported by a grant from the Dutch Burns Foundation
   (grant number 07.109). No financial support was received from the
   producers of the tested materials. None of the authors had a conflict of
   interest.
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NR 40
TC 69
Z9 81
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2012
VL 20
IS 6
BP 797
EP 805
DI 10.1111/j.1524-475X.2012.00845.x
PG 9
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 031ZA
UT WOS:000310680200003
PM 23110478
DA 2026-07-24
ER
PT J
AU Franklin, ME
   Alvarez, A
   Russek, K
AF Franklin, Morris E.
   Alvarez, Allen
   Russek, Karla
TI Negative Pressure Therapy: A Viable Option for General Surgical
   Management of the Open Abdomen
SO SURGICAL INNOVATION
LA English
DT Review
DE nontraumatic surgery; open abdomen; temporary abdominal closure
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM-ASSISTED CLOSURE; FASCIAL CLOSURE;
   WOUND CLOSURE; VENTRAL HERNIA; DAMAGE CONTROL; PACK TECHNIQUE;
   EXPERIENCE; TRAUMA
AB Background. Management of the open abdomen (OA) is challenging for surgeons and requires experienced medical teamwork. The need for improvements in temporary abdominal closure methods has led to the development of a negative-pressure therapy (NPT; ABThera OA NPT, KCI USA, Inc, San Antonio, TX). Method. The authors present a 19-patient case series documenting their use of NPT for OA management in nontraumatic surgery. All received NPT until the fascia was considered ready for closure. Results. Of 19 patients, 17 (89.5%) achieved fascial closure with a Kaplan-Meier (KM) median time to closure of 6 days. Mean hospital and intensive care unit stays were 32.1 and 26.6 days, respectively. During their hospitalization, 5 patients (26.3%) died, with a KM median time to mortality of 53 days. Conclusion. These findings demonstrate effective use of NPT for managing the OA in critically ill patients, and this has led the authors to use it in their general surgery practice.
C1 [Franklin, Morris E.; Alvarez, Allen; Russek, Karla] Texas Endosurg Inst, San Antonio, TX 78222 USA.
RP Franklin, ME (通讯作者)，Texas Endosurg Inst, 4242 E Southcross Blvd,Suite 1, San Antonio, TX 78222 USA.
EM fellow@texasendosurgery.com
CR Adkins AL, 2004, AM SURGEON, V70, P137
   Aydin C, 2008, LANGENBECK ARCH SURG, V393, P67, DOI 10.1007/s00423-007-0189-y
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NR 32
TC 11
Z9 11
U1 0
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD DEC
PY 2012
VL 19
IS 4
BP 353
EP 363
DI 10.1177/1553350611429693
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 031ZH
UT WOS:000310680900002
PM 22228757
DA 2026-07-24
ER
PT J
AU Rasilainen, SK
   Mentula, PJ
   Leppäniemi, AK
AF Rasilainen, S. K.
   Mentula, P. J.
   Leppaniemi, A. K.
TI Vacuum and mesh-mediated fascial traction for primary closure of the
   open abdomen in critically ill surgical patients
SO BRITISH JOURNAL OF SURGERY
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION; TEMPORARY
   CLOSURE; ASSISTED CLOSURE; AORTIC-ANEURYSM; OPEN MANAGEMENT;
   RECONSTRUCTION; DECOMPRESSION; PERITONITIS; LAPAROTOMY
AB Background: Several temporary abdominal closure techniques have been used in the management of open abdomen. Failure to achieve delayed primary fascial closure results in a large ventral hernia. This retrospective analysis evaluated whether the use of vacuum-assisted closure and mesh-mediated fascial traction (VACM) as temporary abdominal closure improved the delayed primary fascial closure rate compared with non-traction methods.
   Methods: Patients treated with an open abdomen between 2004 and 2010 were analysed.
   Results: Among 50 patients treated with VACM and 54 using non-traction techniques (control group), the delayed primary fascial closure rate was 78 and 44 per cent respectively (P < 0.001); rates among those who survived to abdominal closure were 93 and 59 per cent respectively. Independent predictors of delayed primary fascial closure in multivariable logistic regression analysis were the use of VACM (odds ratio (OR) 4.43, 95 per cent confidence interval 1.64 to 11.99) and diagnosis other than peritonitis, severe acute pancreatitis or ruptured abdominal aortic aneurysm (OR 3.45, 1.07 to 11.04), which represented the main diagnoses. Prophylactic open abdomen was used to inhibit the development of intra-abdominal hypertension more frequently in the VACM group (28 versus 7 per cent; P = 0.008). Twelve per cent of patients in the VACM group developed an enteroatmospheric fistula compared with 19 per cent of control patients. Among survivors, three of 31 treated with VACM and 17 of 36 controls were left with a planned ventral hernia (P = 0.001).
   Conclusion: The indication for open abdomen contributed to the probability of delayed primary fascial closure. VACM resulted in a higher fascial closure rate and lower planned hernia rate than methods that did not provide fascial traction. Copyright (c) 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
C1 [Rasilainen, S. K.; Mentula, P. J.; Leppaniemi, A. K.] Helsinki Univ Cent Hosp, Dept Abdominal Surg, Helsinki, Finland.
C3 University of Helsinki; Helsinki University Central Hospital
RP Rasilainen, SK (通讯作者)，Pihlajatie 6 A,POB 02270, Espoo, Finland.
EM suvi.rasilainen@hus.fi
RI Leppäniemi, Ari/GQZ-7991-2022; Mentula, Panu/H-9025-2019
OI Mentula, Panu/0000-0002-6516-3797
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NR 37
TC 107
Z9 122
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD DEC
PY 2012
VL 99
IS 12
BP 1725
EP 1733
DI 10.1002/bjs.8914
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 032NZ
UT WOS:000310727300016
PM 23034811
OA Bronze
DA 2026-07-24
ER
PT J
AU Leaper, DJ
   Schultz, G
   Carville, K
   Fletcher, J
   Swanson, T
   Drake, R
AF Leaper, David J.
   Schultz, Gregory
   Carville, Keryln
   Fletcher, Jacqueline
   Swanson, Theresa
   Drake, Rebecca
TI Extending the TIME concept: what have we learned in the past 10 years?
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chronic wounds; Debridement; Infection; Inflammation; Moisture balance;
   TIME; Wound bed preparation
ID PRESSURE WOUND THERAPY; RANDOMIZED-CONTROLLED-TRIAL; VENOUS LEG ULCERS;
   NEGATIVE-PRESSURE; NANOCRYSTALLINE SILVER; COST-EFFECTIVENESS; CADEXOMER
   IODINE; BED PREPARATION; DEBRIDEMENT; BIOFILMS
AB The TIME acronym (tissue, infection/inflammation, moisture balance and edge of wound) was first developed more than 10 years ago, by an international group of wound healing experts, to provide a framework for a structured approach to wound bed preparation; a basis for optimising the management of open chronic wounds healing by secondary intention. However, it should be recognised that the TIME principles are only a part of the systematic and holistic evaluation of each patient at every wound assessment. This review, prepared by the International Wound Infection Institute, examines how new data and evidence generated in the intervening decade affects the original concepts of TIME, and how it is translated into current best practice. Four developments stand out: recognition of the importance of biofilms (and the need for a simple diagnostic), use of negative pressure wound therapy (NPWT), evolution of topical antiseptic therapy as dressings and for wound lavage (notably, silver and polyhexamethylene biguanide) and expanded insight of the role of molecular biological processes in chronic wounds (with emerging diagnostics and theranostics). Tissue: a major advance has been the recognition of the value of repetitive and maintenance debridement and wound cleansing, both in time-honoured and novel methods (notably using NPWT and hydrosurgery). Infection/inflammation: clinical recognition of infection (and non infective causes of persisting inflammation) is critical. The concept of a bacterial continuum through contamination, colonisation and infection is now widely accepted, together with the understanding of biofilm presence. There has been a return to topical antiseptics to control bioburden in wounds, emphasised by the awareness of increasing antibiotic resistance. Moisture: the relevance of excessive or insufficient wound exudate and its molecular components has led to the development and use of a wide range of dressings to regulate moisture balance, and to protect peri-wound skin, and optimise healing. Edge of wound: several treatment modalities are being investigated and introduced to improve epithelial advancement, which can be regarded as the clearest sign of wound healing. The TIME principle remains relevant 10 years on, with continuing important developments that incorporate new evidence for wound care.
C1 [Leaper, David J.] Cardiff Univ, Sect Wound Healing, Inst Translat Innovat Methodol & Engagement, Cardiff CF14 4XN, S Glam, Wales.
   [Schultz, Gregory] Univ Florida, Dept Obstet & Gynecol, Inst Wound Res, Gainesville, FL 32611 USA.
   [Carville, Keryln] Silver Chain Nursing Assoc, Osborne Pk, WA, Australia.
   [Carville, Keryln] Curtin Univ Technol, Osborne Pk, WA, Australia.
   [Swanson, Theresa] SW Healthcare, Int Wound Infect Inst, Warrnambool, Vic, Australia.
C3 Cardiff University; State University System of Florida; University of
   Florida; Curtin University
RP Leaper, DJ (通讯作者)，Cardiff Univ, Sect Wound Healing, Inst Translat Innovat Methodol & Engagement, Cardiff CF14 4XN, S Glam, Wales.
EM profdavidleaper@doctors.co.uk
FU BBraun; Convatec; Smith Nephew; Ethicon; Coloplast; Systagenix; KCI;
   Health Point; Hollister Wound Care
FX The authors are grateful to the committee of the International Wound
   Infection Institute for their comments and enhancements to this article.
   The committee members are Terry Swanson - Chair (Australia), David
   Armstrong (USA), Joyce Black (USA), Keryln Carville (Australia), Jose
   Contreras Ruiz (Mexico), Marc Despatis (Canada), Val Edwards-Jones (UK),
   Jacqui Fletcher (UK), Georgina Gethin (Ireland), Jenny Hurlow (USA),
   David Keast (Canada), Patricia Larsen (USA), David Leaper (UK), Heather
   Orsted (Canada), Greg Schultz (USA), Dianne Smith (Australia), Geoff
   Sussman (Australia) and RichardWhite (UK). The authors would also like
   to extend their thanks to the members of the International Advisory
   Board on Wound Bed Preparation, who developed the original TIME
   principles, and to Keith Harding (UK), chair of the International Wound
   Infection Institute, 2007-2012. DJL paid speaker or received research
   grants from BBraun, Convatec, Smith & Nephew, Ethicon, Coloplast,
   Systagenix; GS received research grants from KCI, Health Point, Smith &
   Nephew, and Hollister Wound Care in 2011-2012; KC attended education
   events or presented for Smith & Nephew during 2012; JF paid consultancy
   for KCI, Systagenix, BBraun and Medi in 2011-2012; TS attended education
   events or presented for Coloplast, Smith & Nephew, Convatec,
   Independence Australia, and Molnlycke during 2012; RD undertakes
   freelance writing and editorial assignments.
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NR 90
TC 274
Z9 345
U1 2
U2 95
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2012
VL 9
SU 2
SI SI
BP 1
EP 19
DI 10.1111/j.1742-481X.2012.01097.x
PG 19
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 035UR
UT WOS:000310976200001
PM 23145905
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Lawall, H
AF Lawall, Holger
TI Treatment of chronic wounds
SO VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
LA English
DT Review
DE Chronic wounds; local treatment; wound dressings; ulcer treatment
ID RANDOMIZED CONTROLLED-TRIAL; VENOUS LEG ULCERS; NEGATIVE-PRESSURE
   THERAPY; VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; QUALITY-OF-LIFE;
   VENUS III; MULTICENTER; ULTRASOUND; MANAGEMENT
AB Treatment of underlying diseases is of paramount importance due to the complex genesis of chronic wounds. This should be followed by a stage-adapted wound treatment, which usually consists of a phase-adapted wound debridement, ensued by a moist wound treatment. In case of epithelialization, a phase-specific shift to dry wound treatment should be performed. Despite the growing number of new wound dressings and therapeutics, current scientific data is incomplete, and evidence for the effectiveness of these wound dressings is only sparse. No significant advantage of one wound dressing over the other exists.
   The status of negative pressure treatment is still controversial, and no clear evidence is present. In order to achieve a permanent treatment success, causal therapy of venous obstructions and/or arterial disorders is of importance. Systematic and consistent compression therapy is of utmost significance when treating venous wounds.
C1 Asklepios W Klinikum Hamburg, Gefasszentrum, DE-22559 Hamburg, Germany.
RP Lawall, H (通讯作者)，Asklepios W Klinikum Hamburg, Gefasszentrum, Suurheid 20, DE-22559 Hamburg, Germany.
EM H.Lawall@asklepios.com
CR Al Ghazal P, 2011, WUND MANAGEMENT, V5, P254
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NR 56
TC 11
Z9 13
U1 0
U2 63
PU VERLAG HANS HUBER HOGREFE AG
PI BERN 9
PA LAENGGASS-STRASSE 76, CH-3000 BERN 9, SWITZERLAND
SN 0301-1526
J9 VASA
JI Vasa
PD NOV
PY 2012
VL 41
IS 6
BP 396
EP 409
DI 10.1024/0301-1526/a000230
PG 14
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 036ZW
UT WOS:000311071800003
PM 23129035
DA 2026-07-24
ER
PT J
AU Wedemeyer, J
   Kubicka, S
   Lankisch, TO
   Wirth, T
   Patecki, M
   Hiss, M
   Manns, MP
   Schneider, AS
AF Wedemeyer, Jochen
   Kubicka, Stefan
   Lankisch, Tim O.
   Wirth, Thomas
   Patecki, Margret
   Hiss, Marcus
   Manns, Michael P.
   Schneider, Andrea S.
TI Transgastrically placed endoscopic vacuum-assisted closure system as an
   addition to transgastric necrosectomy in necrotizing pancreatitis
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Article
ID PRESSURE WOUND THERAPY; ESOPHAGEAL LEAKAGE
AB Background: Endoscopic transluminal debridement of infected pancreatic necrosis has been proved to be an important alternative to surgical debridement. Recently, endoscopic vacuum-assisted closure (EVAC) has been described as a new effective treatment option in upper intestinal anastomotic leaks.
   Objective: To test whether the EVAC can be applied to transgastrically accessible infected cavities.
   Design: Single-center case study.
   Setting: Academic medical center.
   Patients: Two patients with necrotizing pancreatitis.
   Main Outcome Measurement: Successful closure of leak.
   Results: We successfully applied EVAC to treat transgastrically accessible necrotic cavities.
   Limitations: Small case number.
   Conclusions: EVAC might be an important additional endoscopic treatment option for infected pancreatic necrosis, especially if established endoscopic treatment options fail.
C1 [Wedemeyer, Jochen; Kubicka, Stefan; Lankisch, Tim O.; Wirth, Thomas; Manns, Michael P.; Schneider, Andrea S.] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-3000 Hannover, Germany.
   [Patecki, Margret; Hiss, Marcus] Hannover Med Sch, Dept Nephrol, D-3000 Hannover, Germany.
   [Wedemeyer, Jochen] Robert Koch Hosp Gehrden, Dept Med 1, Gehrden, Germany.
   [Kubicka, Stefan] Kreiskliniken Reutlingen, Dept Med 1, Reutlingen, Germany.
C3 Hannover Medical School; Hannover Medical School
RP Wedemeyer, J (通讯作者)，Klinikum Reg Hannover, Robert Koch Hosp, Dept Med 1, Von Reden Str 1, D-30989 Gehrden, Germany.
EM jochen.wedemeyer@krh.eu
RI Patecki, Margret/GLQ-8590-2022; Manns, Michael/AFG-3063-2022
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
   Banks PA, 2006, AM J GASTROENTEROL, V101, P2379, DOI 10.1111/j.1572-0241.2006.00856.x
   Gardner TB, 2011, GASTROINTEST ENDOSC, V73, P718, DOI 10.1016/j.gie.2010.10.053
   Holle G, 2007, UNFALLCHIRURG, V110, P490, DOI 10.1007/s00113-007-1267-x
   Loske G, 2011, ENDOSCOPY, V43, P540, DOI 10.1055/s-0030-1256345
   Seifert H, 2000, LANCET, V356, P653, DOI 10.1016/S0140-6736(00)02611-8
   Seifert H, 2009, GUT, V58, P1260, DOI 10.1136/gut.2008.163733
   Sermoneta D, 2010, INT WOUND J, V7, P525, DOI 10.1111/j.1742-481X.2010.00727.x
   Thompson JT, 2007, CLIN PLAST SURG, V34, P673, DOI 10.1016/j.cps.2007.07.005
   Vikatmaa P, 2008, EUR J VASC ENDOVASC, V36, P438, DOI 10.1016/j.ejvs.2008.06.010
   Wedemeyer J, 2010, GASTROINTEST ENDOSC, V71, P382, DOI 10.1016/j.gie.2009.07.011
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 12
TC 16
Z9 20
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD DEC
PY 2012
VL 76
IS 6
BP 1238
EP 1241
DI 10.1016/j.gie.2012.08.014
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 040TT
UT WOS:000311347800020
PM 23025973
DA 2026-07-24
ER
PT J
AU Begum, SSS
   Papagiannopoulos, K
AF Begum, Shah S. S.
   Papagiannopoulos, Kostas
TI The Use of Vacuum-Assisted Wound Closure Therapy in Thoracic Operations
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID NEGATIVE-PRESSURE; EMPYEMA; MANAGEMENT; POSTPNEUMONECTOMY; PROMOTE;
   DEVICE; TRIAL
AB Background. Conventional treatment of complex, non-resolving empyemas after an episode of pneumonia or a chest operation often requires an open-window thoracostomy. This necessitates frequent, often painful dressing changes and is associated with prolonged hospitalization. The wound is often malodorous, causing significant social distress to patients and unquestionably affects their quality of life. We assessed the value of using vacuum-assisted closure (VAC) therapy in managing patients with a persistent infected pleural space.
   Methods. The study included 10 patients. All patients signed an informed consent and were debriefed before the procedure. An empyema developed in 1 patient after an episode of pneumonia. The other 9 had recently undergone a thoracic surgical procedure. All patients underwent initial open drainage of the pleural cavity and debridement. A VAC therapy system was then inserted intraoperatively or on the first postoperative day. The patients were discharged home with a portable VAC therapy system in situ. Subsequent dressing changes were managed by tissue-viability nurses in the community, without the need for further anesthesia or analgesia. Over a period of time, the cavity was sterilized and eventually obliterated spontaneously.
   Results. All patients were mobilized early and fast-tracked through the hospital. This prevented the need for daily dressing changes; hence, minimizing the disruption of normal activities and reducing the need for nursing care. Overall, the length of hospitalization was shorter, and the VAC therapy facilitated closure of the infected wound cavity. The use of the VAC therapy system negated the need for a second surgical procedure to close the wound cavity. None of the patients reported pain, odor, or inconvenience associated with the VAC therapy system.
   Conclusions. Our observations suggest that the use of VAC therapy to treat such patients is safe, facilitates early discharge and recovery, and offers a "civilized," cost-effective treatment in a community setting.
C1 [Begum, Shah S. S.; Papagiannopoulos, Kostas] St James Univ Hosp, Dept Thorac Surg, Leeds LS9 7TF, W Yorkshire, England.
C3 Saint James's University Hospital
RP Papagiannopoulos, K (通讯作者)，St James Univ Hosp, Dept Thorac Surg, Level 3,Bexley Wing, Leeds LS9 7TF, W Yorkshire, England.
EM kpapagiannopoulos@yahoo.com
OI Papagiannopoulos, Konstantinos/0000-0002-7088-8004
CR Al-Mufarrej F, 2010, SURG TODAY, V40, P711, DOI 10.1007/s00595-008-4096-9
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 19
TC 15
Z9 20
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD DEC
PY 2012
VL 94
IS 6
BP 1835
EP 1840
DI 10.1016/j.athoracsur.2012.08.009
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 041XW
UT WOS:000311436300019
PM 23122932
OA Bronze
DA 2026-07-24
ER
PT J
AU Kheirabadi, BS
   Terrazas, IB
   Williams, JF
   Hanson, MA
   Dubick, MA
   Blackbourne, LH
AF Kheirabadi, Bijan S.
   Terrazas, Irasema B.
   Williams, James F.
   Hanson, Margaret A.
   Dubick, Michael A.
   Blackbourne, Lorne H.
TI Negative-pressure wound therapy: A hemostatic adjunct for control of
   coagulopathic hemorrhage in large soft tissue wounds
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; hemostatic adjunct; coagulopathy; swine
ID VACUUM-ASSISTED CLOSURE; INJURIES; MANAGEMENT
AB BACKGROUND: Negative-pressure wound therapy has been commonly used for treating chronic wounds and recently applied for treatment of traumatic wounds. We investigated the potential hemostatic benefit of negative-pressure wound therapy for control of refractory hemorrhage in a soft tissue wound model in swine.
   METHODS: Coagulopathy was induced in pigs (n = 38, 36 kg) by hemodilution and hypothermia. Next, a large soft tissue wound (diameter, approximately 20 cm) was created by slicing the gluteus maximus muscle. Free bleeding was allowed for 1 minute, and wounds were then randomly dressed with either laparotomy gauze (G) alone or TraumaPad (TP, a kaolin-coated dressing) alone or in combination with negative pressure (NP, approximately -500 mm Hg). All wounds were sealed with adhesive drapes. Fluid resuscitation was administered and targeted to mean arterial pressure of 60 mm Hg. Pigs were observed for 150 minutes or until death after which tissues were sampled for histologic examination.
   RESULTS: Induced coagulopathy as measured by increases in prothrombin time (12%) and activated partial thromboplastin time (22%) and decreases in fibrinogen (48%) were similar in all groups. There were no differences in initial bleeding rates (4.5 mL/kg/min). Dressing the wounds with G or TP produced hemostasis only in one pig (1 of 18 pigs). Addition of NP to these dressings secured hemostasis in 70% (G) and 90% (TP) of animals with average hemostasis time of 34 minutes and 25 minutes, respectively. Blood losses and fluid resuscitation requirements were significantly less, and survival times were significantly longer in NP adjunct groups than in the other groups. Survival rates were 80% (G+NP) and 90% (TP+NP) versus 0% (G) and 10% (TP) in the respective groups. Histologic examination showed similar superficial myofibril damages in all groups.
   CONCLUSION: To our knowledge, the present data provide the first evidence that NP serves as an effective hemostatic adjunct and when combined with standard hemostatic dressing it is able to stop lethal coagulopathic bleeding in large soft tissue wounds. (J Trauma Acute Care Surg. 2012; 73: 1188-1194. Copyright (c) 2012 by Lippincott Williams & Wilkins)
C1 [Kheirabadi, Bijan S.; Terrazas, Irasema B.; Williams, James F.; Hanson, Margaret A.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Kheirabadi, BS (通讯作者)，3650 Chambers Pass,BHT2,Bldg 3610, Ft Sam Houston, TX 78234 USA.
EM BIJAN.KHEIRABADI@US.ARMY.MIL
FU US Army Medical Research and Materiel Command; Veterinary Support Branch
FX We express our sincere gratitude to Dr. Harold Klemcke for his careful
   review and editorial assistance of the article. We also acknowledge our
   Veterinary Support Branch for their support and assistance in conducting
   these experiments. The excellent technical assistance by Dr. Adekoye
   Sanni (DVM), SPC Birk Greene, and SPC Alice Craig is greatly
   appreciated.The funding for this work was provided solely by the US Army
   Medical Research and Materiel Command.
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NR 24
TC 10
Z9 10
U1 2
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2012
VL 73
IS 5
BP 1188
EP 1194
DI 10.1097/TA.0b013e31826f98ea
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 043VF
UT WOS:000311577100028
PM 23117379
DA 2026-07-24
ER
PT J
AU Ramanujam, CL
   Zgonis, T
AF Ramanujam, Crystal L.
   Zgonis, Thomas
TI Surgical Soft Tissue Closure of Severe Diabetic Foot Infections: A
   Combination of Biologics, Negative Pressure Wound Therapy, and Skin
   Grafting
SO CLINICS IN PODIATRIC MEDICINE AND SURGERY
LA English
DT Article
DE Diabetic foot; Wounds; Neuropathy; Biologics; Negative pressure wound
   therapy; Amputation
AB Creative surgical strategies are often warranted for long-term closure of diabetic foot wounds. This article provides a case report describing the successive use of negative pressure wound therapy, advanced biologics, and split thickness skin grafting for healing an extensive surgical wound. Although the success of these therapies is enticing, their use should be based on careful patient selection in a multidisciplinary setting.
C1 [Ramanujam, Crystal L.; Zgonis, Thomas] Univ Texas Hlth Sci Ctr San Antonio, Dept Orthopaed Surg, Div Podiatr Med & Surg, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas at San Antonio
RP Zgonis, T (通讯作者)，Univ Texas Hlth Sci Ctr San Antonio, Dept Orthopaed Surg, Div Podiatr Med & Surg, 7703 Floyd Curl Dr MSC 7776, San Antonio, TX 78229 USA.
EM zgonis@uthscsa.edu
CR Capobianco Claire M, 2010, Foot Ankle Spec, V3, P241, DOI 10.1177/1938640010375113
   Clemens Mark W, 2010, Surg Technol Int, V20, P61
   Collier Mark, 2006, Nurs Stand, V21, ppassim
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   Ramsey SD, 1999, DIABETES CARE, V22, P382, DOI 10.2337/diacare.22.3.382
   Reiber GE, 1998, AM J SURG, V176, p5S, DOI 10.1016/S0002-9610(98)00181-0
   Roukis TS, 2009, SURG RECONSTRUCTION, P129
NR 7
TC 8
Z9 11
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0891-8422
EI 1558-2302
J9 CLIN PODIATR MED SUR
JI Clin. Podiatr. Med. Surg.
PD JAN
PY 2012
VL 29
IS 1
BP 143
EP +
DI 10.1016/j.cpm.2011.10.004
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 044VB
UT WOS:000311651100014
PM 22243576
DA 2026-07-24
ER
PT J
AU Watt, AJ
   Friedrich, JB
   Huang, JI
AF Watt, Andrew J.
   Friedrich, Jeffrey B.
   Huang, Jerry I.
TI Advances in Treating Skin Defects of the Hand Skin Substitutes and
   Negative-Pressure Wound Therapy
SO HAND CLINICS
LA English
DT Article
DE Hand reconstruction; Skin substitute; Dermal substitute; VAC; Integra
ID DERMAL REGENERATION TEMPLATE; CLINICAL-TRIAL; TISSUE DEFECTS; MATRIX;
   ALLOGRAFT; CLOSURE; INTEGRA; GRAFTS; RECONSTRUCTION; MANAGEMENT
AB Surgeons and scientists have been developing alternative methods of hand reconstruction that may play an adjunctive role to, or completely supplant, more traditional reconstructive modalities. This article provides an overview of these emerging techniques, with an emphasis on skin substitutes and negative-pressure wound therapy as they apply to the treatment of soft tissue defects of the hand. The indications, contraindications, and relative advantages and disadvantages of these techniques are discussed in detail.
C1 [Watt, Andrew J.; Huang, Jerry I.] Univ Washington, Hand Ctr, Seattle, WA 98105 USA.
   [Watt, Andrew J.; Huang, Jerry I.] Univ Washington, Dept Orthoped Surg & Sports Med, Seattle, WA 98105 USA.
   [Friedrich, Jeffrey B.] Univ Washington, Dept Surg, Div Plast Surg, Seattle, WA 98105 USA.
   [Friedrich, Jeffrey B.] Univ Washington, Dept Orthopaed, Seattle, WA 98105 USA.
   [Friedrich, Jeffrey B.] Univ Washington, Harborview Med Ctr, Seattle, WA 98104 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle; University of Washington;
   University of Washington Seattle; Harborview Medical Center; University
   of Washington; University of Washington Seattle
RP Watt, AJ (通讯作者)，Univ Washington, Hand Ctr, 4245 Roosevelt Ave NE,Box 354740, Seattle, WA 98105 USA.
EM ajwatt50@gmail.com
OI Friedrich, Jeffrey/0000-0002-5245-9708
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NR 35
TC 14
Z9 15
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0712
EI 1558-1969
J9 HAND CLIN
JI Hand Clin.
PD NOV
PY 2012
VL 28
IS 4
BP 519
EP +
DI 10.1016/j.hcl.2012.08.010
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 047XW
UT WOS:000311875800008
PM 23101602
DA 2026-07-24
ER
PT J
AU Tian, M
   Jiang, YZ
   Niu, YW
   Xiao, YR
   Lu, SL
   Wang, XQ
AF Tian, Ming
   Jiang, Yu-Zhi
   Niu, Yi-Wen
   Xiao, Yu-Rui
   Lu, Shu-Liang
   Wang, Xi-Qiao
TI A Severely Infected Diabetic Foot Treated Successfully Without Using
   Systemic Antibiotics
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE antibiotic; diabetic foot; infection
ID RESISTANT STAPHYLOCOCCUS-AUREUS; VACUUM-ASSISTED CLOSURE;
   INTERNATIONAL-CONSENSUS; PRACTICAL GUIDELINES; ULCERS; PREVENTION;
   FOUNDATION; MANAGEMENT; EXPRESSION; THERAPY
AB About 50% to 70% of all lower extremity amputations are related to diabetes infection. And antibiotic therapy is routinely used for all infected wounds to reduce the mortality of diabetic foot. Here, we report a case of diabetic foot with acute and deep severe infection. During hospital therapy, we used negative pressure therapy and extensive debridement without systemic antibiotic application, and we successfully rescued a foot from amputation. Negative pressure therapy and extensive debridement are very important and effective methods to control infection and promote wound healing in diabetes foot.
C1 [Tian, Ming; Jiang, Yu-Zhi; Niu, Yi-Wen; Xiao, Yu-Rui; Lu, Shu-Liang; Wang, Xi-Qiao] Jiao Tong Univ, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University
RP Wang, XQ (通讯作者)，Jiao Tong Univ, Inst Burn, Ruijin Hosp, Sch Med, 197 Ruijin Rd, Shanghai 200025, Peoples R China.
EM boyamedicine@163.com
OI Tian, Ming/0000-0003-1665-321X
FU National Natural Science Foundation of China [30872686, 81071568];
   Shanghai Municipal Education Commission [11CXY38]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by grants from the National Natural Science Foundation of
   China (No. 30872686 and No. 81071568) and Scientific Innovation Project
   of Shanghai Municipal Education Commission (11CXY38).
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NR 18
TC 6
Z9 7
U1 0
U2 16
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2012
VL 11
IS 4
BP 296
EP 298
DI 10.1177/1534734612458286
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 048KC
UT WOS:000311909200009
PM 23089961
DA 2026-07-24
ER
PT J
AU Glaser, DA
   Farnsworth, CL
   Varley, ES
   Nunn, TA
   Sayad-Shah, M
   Breisch, EA
   Yaszay, B
AF Glaser, Diana A.
   Farnsworth, Christine L.
   Varley, Eric S.
   Nunn, Thomas A.
   Sayad-Shah, Mehria
   Breisch, Eric A.
   Yaszay, Burt
TI Negative Pressure Therapy for Closed Spine Incisions: A Pilot Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; RISK-FACTORS; WOUND
   INFECTIONS; MANAGEMENT; RESISTANCE; PIG
AB Negative pressure therapy (NPT), used on open wounds or postoperative infections, has not been evaluated on closed spinal incisions. This was analyzed after 3 days and 5 days of NPT application using biomechanics and histology in a porcine model. Methods. In, 8 mature miniature pigs, 2 end-to-end midline spine incisions were closed in a standard fashion. Negative pressure (Prevena (TM) Incision Management System, KCI, San Antonio, TX) was applied to one incision.(NPT group) while standard dry dressings were used on the other (control group). After 3 days or 5 days, all incisions underwent biomechanical (eg, failure load, failure energy, and stress), histological, and scar scale evaluation Analysis. ANOVAs compared the groups (3 day vs 5-day, NPT vs control, P < 0.05). Negative pressure therapy demonstrated a significantly improved scar scale height grade than the control (P = 0.026). Failure load (4.9 +/- 4.0 vs 16.5 +/- 14.6 N), energy. absorbed (8.0 +/- 9.0 vs 26.9 +/- 23.0 mJ), and ultimate stress (62 +/- 53 vs. 204 +/- 11.8 N/mm(2)) were lower in the control group. Histological analysis revealed no differences in incision scar width. Conclusion. Negative pressure therapy application on closed. incisions presented, a trend toward improved;early healing strength, and in significantly improved incision appearance. Clinically, NPT may improve incision. integrity minimizing the risk of dehiscence or subsequent infection. Patients at high risk of postoperative incision site complications may. benefit from primary application of NPT.
C1 [Glaser, Diana A.; Farnsworth, Christine L.; Nunn, Thomas A.; Breisch, Eric A.; Yaszay, Burt] Rady Childrens Hosp, Orthoped Biomech Res Ctr, San Diego, CA USA.
   [Varley, Eric S.; Sayad-Shah, Mehria] Univ Calif San Diego, Dept Orthopaed Surg, San Diego, CA 92103 USA.
C3 Rady Childrens Hospital San Diego; University of California System;
   University of California San Diego
RP Farnsworth, CL (通讯作者)，Childrens Specialists San Diego, Dept Orthoped Res, 3020 Childrens Way,MC 5054, San Diego, CA 92123 USA.
EM cfarnsworth@rchsd.org
RI Farnsworth, Christine/Q-5617-2018
OI Farnsworth, Christine/0000-0001-7615-3749
FU KCI Medical, San Antonio,TX; KCI Medical, Inc
FX This study was supported by a research grant from KCI Medical, San
   Antonio,TX.The authors would like to recognize and thank Tracey Bastrom,
   MA, for statistical analysis; JD Bomar for figure development; and KCI
   Medical, Inc for research support.
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NR 28
TC 33
Z9 36
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2012
VL 24
IS 11
BP 308
EP 316
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 048NK
UT WOS:000311919000002
PM 25876166
DA 2026-07-24
ER
PT J
AU Lancerotto, L
   Bayer, LR
   Orgill, DP
AF Lancerotto, Luca
   Bayer, Lauren R.
   Orgill, Dennis P.
TI Mechanisms of action of microdeformational wound therapy
SO SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE Microdeformational wound therapy; Negative pressure; Wound therapy;
   NPWT; Microdeformation; Sub-atmospheric; Angiogenesis; Granulation;
   Foam; Dressing; Wound closure; Wound healing
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; IN-VIVO; SKIN;
   GROWTH; PROLIFERATION; EXPRESSION; MANAGEMENT; GRAFTS; TRAUMA
AB Microdeformational Wound Therapy (MDWT) is a class of medical devices that have revolutionized the treatment of complex wounds over the last 20 years. These devices, are a subset of Negative Pressure Wound Therapy (NPWT), in which there is a highly porous interface material placed between the wound and a semi-occlussive dressing and connected to suction. The porous interface material acts to deform the wound on a micro scale promoting cellular proliferation. These devices appear to significantly improve the speed of healing in many wounds, facilitate granulation tissue formation and reduce the complexity of subsequent reconstructive operations. The mechanisms through which such effects are obtained are beginning to be better understood through basic research and clinical trials. Further work in this field is likely to yield devices that are designed to treat specific wound types. (c) 2012 Elsevier Ltd. All rights reserved.
C1 [Lancerotto, Luca; Orgill, Dennis P.] Brigham & Womens Hosp, Div Plast Surg, Tissue Engn & Wound Healing Lab, Boston, MA 02115 USA.
   [Lancerotto, Luca] Univ Padua, Inst Plast Reconstruct & Aesthet Surg, I-35100 Padua, Italy.
   [Lancerotto, Luca; Orgill, Dennis P.] Harvard Univ, Sch Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; University of Padua; Harvard University; Harvard
   Medical School
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, Tissue Engn & Wound Healing Lab, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Lancerotto, Luca/A-5745-2013; Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
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   Stinner DJ, 2011, J TRAUMA, V71, pS147, DOI 10.1097/TA.0b013e318221944a
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NR 66
TC 57
Z9 62
U1 0
U2 23
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1084-9521
J9 SEMIN CELL DEV BIOL
JI Semin. Cell Dev. Biol.
PD DEC
PY 2012
VL 23
IS 9
BP 987
EP 992
DI 10.1016/j.semcdb.2012.09.009
PG 6
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA 049DS
UT WOS:000311962800007
PM 23036531
DA 2026-07-24
ER
PT J
AU Gutierrez, IM
   Gollin, G
AF Gutierrez, Ivan M.
   Gollin, Gerald
TI Negative pressure wound therapy for children with an open abdomen
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE VAC; Open abdomen; Abdominal compartment syndrome; Negative pressure
   wound therapy
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; DAMAGE-CONTROL;
   MANAGEMENT; DEHISCENCE; EXPERIENCE
AB The utility of negative pressure wound therapy (NPWT) in the management of adults with an open abdomen has been well documented. We reviewed our experience with NPWT in the management of infants and children with this condition.
   The records of all children who were treated with NPWT for an open abdomen between March 2005 and September 2009 at a single children's hospital were reviewed.
   Twenty-five subjects were identified. They included children who developed abdominal compartment syndrome after a laparotomy (n = 12) or in whom the abdomen could not be safely closed at the time of laparotomy (n = 13). NWPT was accomplished with the vacuum-assisted closure (VACA (R)) system in all patients. The median duration for NPWT was 4.5 days. In 16 subjects, the abdomen was closed successfully after NPWT. In 14 children, the abdominal wall fascia was successfully approximated, and two children underwent a patch abdominal closure. But nine subjects died before an abdominal closure could be attempted. Only two (12.5%) children developed enterocutaneous fistulae.
   NPWT is a reliable tool for infants and children with an open abdomen. Wound management was facilitated and abdominal wall closure was ultimately achieved in all survivors. Enterocutaneous fistulae developed in two children, however, these were likely due to underlying bowel injury and would have occurred despite variations in management of the open abdomen.
C1 [Gutierrez, Ivan M.; Gollin, Gerald] Loma Linda Univ, Sch Med, Div Pediat Surg, Loma Linda, CA 92354 USA.
C3 Loma Linda University
RP Gollin, G (通讯作者)，Loma Linda Univ, Sch Med, Div Pediat Surg, 11175 Campus St,CP 21111, Loma Linda, CA 92354 USA.
EM ggollin@llu.edu
CR Amin AI, 2009, WORLD J GASTROENTERO, V15, P3394, DOI 10.3748/wjg.15.3394
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NR 21
TC 12
Z9 14
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD DEC
PY 2012
VL 397
IS 8
BP 1353
EP 1357
DI 10.1007/s00423-012-0923-y
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 050PR
UT WOS:000312067000021
PM 22382700
DA 2026-07-24
ER
PT J
AU Mees, J
   Mardin, WA
   Senninger, N
   Bruewer, M
   Palmes, D
   Mees, ST
AF Mees, Julia
   Mardin, Wolf Arif
   Senninger, Norbert
   Bruewer, Matthias
   Palmes, Daniel
   Mees, Soeren Torge
TI Treatment options for postoperatively infected abdominal wall wounds
   healing by secondary intention
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Wound healing; Postoperative wound infection; Standardized treatment;
   Pathway
ID VACUUM-ASSISTED CLOSURE; DRESSINGS; MANAGEMENT; THERAPY
AB We present our current clinical approach for the treatment of postoperatively infected wounds of the abdominal wall healing by secondary intention that may help in the design of a randomized controlled trial to develop a standardized wound treatment pathway.
   Patients with postoperatively infected abdominal wounds treated with either Advanced Wound Care (AWC) dressings or vacuum-assisted closure (VAC) therapy were enrolled in the study. Follow-up was carried out prospectively for wound healing and incidence of incisional hernia at the earliest 3 years after surgery.
   Sixty-two patients were included and wounds were initially treated antiseptically for 5.19 +/- 2.91 days. Prior to VAC therapy, AWC dressings were applied for 8.75 +/- 2.93 days to reduce reinfection. Greater wound size (> 12 x 6 x 6cm) and extensive secretion (> 200 ml/day) argued for the VAC system. Overall incidence of incisional hernia was 20.4 %, with 18.4 % occurring in AWC-treated patients and 27.3 % in VAC-treated patients. Based on these results, a wound treatment pathway was established in our department.
   The established wound treatment pathway has helped to increase both workflow efficacy and outcome in the treatment of abdominal wounds. Wound size, amount of secretion, and status of infection were the parameters we used for the determination of appropriate treatment. The observational data gathered during the initiation of our pathway lay the basis for future randomized controlled trials that will determine the most appropriate treatment options in the setting of a standardized wound treatment pathway.
C1 [Mees, Julia; Mardin, Wolf Arif; Senninger, Norbert; Bruewer, Matthias; Palmes, Daniel; Mees, Soeren Torge] Univ Hosp Munster, Dept Gen & Visceral Surg, D-48149 Munster, Germany.
C3 University of Munster
RP Mees, ST (通讯作者)，Univ Hosp Munster, Dept Gen & Visceral Surg, Waldeyerstr 1, D-48149 Munster, Germany.
EM soerentorge.mees@ukmuenster.de
FU Systagenix Wound Management, Norderstedt, Germany
FX This project was funded by an unrestricted educational grant from
   Systagenix Wound Management, Norderstedt, Germany, formerly Johnson &
   Johnson Wound Management.
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NR 18
TC 15
Z9 16
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1435-2443
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD DEC
PY 2012
VL 397
IS 8
BP 1359
EP 1366
DI 10.1007/s00423-012-0988-7
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 050PR
UT WOS:000312067000022
PM 22875224
DA 2026-07-24
ER
PT J
AU Azzopardi, EA
   Boyce, DE
   Dickson, WA
   Azzopardi, E
   Laing, JHE
   Whitaker, IS
   Shokrollahi, K
AF Azzopardi, Ernest Anthony
   Boyce, Dean E.
   Dickson, William A.
   Azzopardi, Elayne
   Laing, James Hamish Ellsworth
   Whitaker, Iain S.
   Shokrollahi, Kayvan
TI Application of Topical Negative Pressure (Vacuum-Assisted Closure) to
   Split-Thickness Skin Grafts A Structured Evidence-Based
   Review
SO ANNALS OF PLASTIC SURGERY
LA English
DT Review
DE topical negative pressure; VAC; negative pressure wound therapy;
   split-thickness skin graft
ID SIGNAL-TRANSDUCTION; THERAPY; PROLIFERATION; BOLSTER
AB Introduction: Significant controversy surrounds the effectiveness of negative pressure wound therapy although it has been in use for decades. Although many clinicians favor this modality in relation to its practicality, ease of use especially in complex wounds, it has faced the same challenges as other dressings in relation to evidence base of efficacy in relation to a number of outcome measures. In view of the current financial pressures on health care systems worldwide, this structured review systematically challenges the evidence for perioperative application of topical negative pressure (TNP) to split-thickness skin grafts (STSGs) through evidence-based critical appraisal, and extrapolate the mechanisms of action on the mechanisms through which TNP may aid wound healing. Weighted evidence-based recommendations regarding the impact of TNP on split skin graft quality and quantity of take as outcomes.
   Methods: Phase 1: Structured literature search. Phase 2: Retrieved articles were critically appraised for rigor and methodological validity by 3 independent authors, then stratified according to a validated "levels of evidence" framework. Graded "current best evidence" recommendations could therefore be proposed.
   Results: Of the 220 studies retrieved in the initial search, 38 studies satisfied our quality of evidence criteria. Current best evidence supports 2 complementary trends explaining the mechanisms whereby STSG benefits from TNP. Active stimulation of epithelial mitosis: TNP creates mechanical stretch which stimulates multiple signaling pathways up-regulating growth-and mitosis-associated epithelial transcription factors. Topical negative pressure also promotes microcirculatory flow (graft and wound edge), stimulates angiogenesis and basement membrane integrity (grade C). Prevention of complications: significant reduction of graft lift-off by edema, exudates, subgraft hematoma, and reduction of shear when compared to traditional dressings (grade B). Topical negative pressure promotes significant qualitative improvement in the final STSG result studies (level 1B). The role of TNP in prevention of infection is, however, equivocal and further research is required. No evidence of harm from TNP application was reported.
   Conclusions: Topical negative pressure increases quantity and quality of split skin graft take compared to traditional bolster dressings. The advantages are increased in irregularly contoured, technically difficult wounds and suboptimal recipient wound beds where it seems to be the best modality currently available. Large-scale randomized clinical controlled trials remain scanty in all areas of wound dressing research including negative pressure therapy.
C1 [Azzopardi, Ernest Anthony; Boyce, Dean E.; Dickson, William A.; Laing, James Hamish Ellsworth; Whitaker, Iain S.; Shokrollahi, Kayvan] Morriston Hosp, Welsh Ctr Burns & Plast Surg, Swansea, W Glam, Wales.
   [Azzopardi, Ernest Anthony] Cardiff Univ, Sch Dent, Cardiff, S Glam, Wales.
   [Azzopardi, Elayne] Manchester Metropolitan Univ, Fac Hlth Psychol & Social Care, Res Inst Hlth & Social Change, Manchester M15 6BH, Lancs, England.
   [Azzopardi, Elayne] Whiston Hosp, Mersey Reg Burns & Plast Surg Unit, Liverpool, Merseyside, England.
C3 Morriston Hospital; Cardiff University; Manchester Metropolitan
   University; Whiston Hospital
RP Shokrollahi, K (通讯作者)，Morriston Hosp, Welsh Ctr Burns & Plast Surg, Swansea, W Glam, Wales.
EM kshokrollahi@hotmail.com
RI Whitaker, Iain/O-5896-2019; Laing, Hamish/AAN-3921-2020; Shokrollahi,
   Kayvan/V-4993-2019; /AAE-2342-2021
OI Whitaker, Iain/0000-0002-3922-2079; Laing, Hamish/0000-0002-5661-7937;
   Azzopardi, Ernest/0000-0002-4511-0954; Shokrollahi,
   Kayvan/0000-0003-1044-7781; 
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NR 48
TC 59
Z9 75
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JAN
PY 2013
VL 70
IS 1
BP 23
EP 29
DI 10.1097/SAP.0b013e31826eab9e
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 056KJ
UT WOS:000312487400006
PM 23249474
DA 2026-07-24
ER
PT J
AU Seifarth, FG
   Knight, CG
AF Seifarth, Federico G.
   Knight, Colin G.
TI A Simple Postoperative Umbilical Negative-Pressure Dressing
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE umbilical wounds; vacuum-assisted closure; negative-pressure wound
   dressing; laparoscopy; wound infection
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; WOUNDS; EXPERIENCE; THERAPY
AB Application of umbilical wound dressings is challenging because of the shape and depth of the navel. Dressing changes and umbilical wound cleaning as practiced by many surgeons are painful procedures. The authors describe a simple and durable postoperative umbilical vacuum dressing, providing the advantages of topical negative-pressure wound therapy.
C1 [Seifarth, Federico G.] Pediat Inst & Childrens Hosp, Dept Pediat Surg, Cleveland Clin Fdn, Cleveland, OH USA.
   [Knight, Colin G.] Miami Childrens Hosp, Dept Pediat Surg, Miami, FL USA.
C3 Cleveland Clinic Foundation
RP Seifarth, FG (通讯作者)，Pediat Inst & Childrens Hosp, Dept Pediat Surg, Cleveland Clin Fdn, Cleveland, OH USA.
CR Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Baharestani M, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00607.x
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
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NR 10
TC 6
Z9 9
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1527-7941
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2013
VL 26
IS 1
BP 26
EP 29
DI 10.1097/01.ASW.0000425937.02498.87
PG 3
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 058OJ
UT WOS:000312643100007
PM 23263397
DA 2026-07-24
ER
PT J
AU Vargo, D
AF Vargo, Daniel
TI Negative pressure wound therapy in the prevention of wound infection in
   high risk abdominal wound closures
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Wound infection; Risk stratification; Wound dressing
ID SURGICAL SITE INFECTIONS; INCISIONS; SCIP
AB BACKGROUND: Wound infections continue to be an issue in abdominal surgery. Tissue perfusion may be a contributing factor. Negative pressure application may have promise in decreasing wound complication.
   METHOD: A retrospective review of prospectively collected data in patients with high-risk abdominal wounds was undertaken. Comorbidities, risk factors for infection, wound classification, and wound outcomes were all evaluated. The primary outcome measure was wound infection rate. Secondary outcomes included device safety and overall surgical site complication rate.
   RESULTS: Thirty patients were identified who had skin flaps in whom negative pressure was used. Negative pressure was applied for an average of 5.6 days (range, 5-7 days). No patient developed ischemia or necrosis of the skin flaps. No wound infections were identified. The overall wound complication rate was 3%. The comparable historical control wound complication rate was 20%, and chi(2) analysis showed a statistically significant decrease in the infection rate with negative-pressure wound therapy (P < .05).
   CONCLUSIONS: Negative-pressure wound therapy applied to a closed, high-risk surgical wound is safe, with no evidence of skin necrosis and decreased wound infection rate. (C) 2012 Published by Elsevier Inc.
C1 Univ Utah, Sch Med, Dept Surg, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah
RP Vargo, D (通讯作者)，Univ Utah, Sch Med, Dept Surg, Salt Lake City, UT 84112 USA.
EM daniel.vargo@hsc.utah.edu
CR Anderson DJ, 2011, INFECT DIS CLIN N AM, V25, P135, DOI 10.1016/j.idc.2010.11.004
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NR 9
TC 39
Z9 47
U1 1
U2 10
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD DEC
PY 2012
VL 204
IS 6
BP 1021
EP 1023
DI 10.1016/j.amjsurg.2012.10.004
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 060UG
UT WOS:000312803000058
PM 23231938
DA 2026-07-24
ER
PT J
AU Turza, KC
   Campbell, CA
   Rosenberger, LH
   Politano, AD
   Davies, SW
   Riccio, LM
   Sawyer, RG
AF Turza, Kristin C.
   Campbell, Chris A.
   Rosenberger, Laura H.
   Politano, Amani D.
   Davies, Stephen W.
   Riccio, Lin M.
   Sawyer, Robert G.
TI Options for Closure of the Infected Abdomen
SO SURGICAL INFECTIONS
LA English
DT Review
ID TEMPORARY ABDOMINAL CLOSURE; ACELLULAR DERMAL MATRIX; PLANNED MULTIPLE
   LAPAROTOMIES; POLYPROPYLENE MESH CLOSURE; INCISIONAL HERNIA REPAIR;
   COMPARTMENT SYNDROME; VENTRAL HERNIA; DAMAGE-CONTROL; FASCIAL CLOSURE;
   WITTMANN PATCH
AB Background: The infected abdomen poses substantial challenges to surgeons, and often, both temporary and definitive closure techniques are required. We reviewed the options available to close the abdominal wall defect encountered frequently during and after the management of complicated intra-abdominal infections.
   Methods: A comprehensive review was performed of the techniques and literature on abdominal closure in the setting of intra-abdominal infection.
   Results: Temporary abdominal closure options include the Wittmann Patch, Bogota bag, vacuum-assisted closure (VAC), the AbThera (TM) device, and synthetic or biologic mesh. Definitive reconstruction has been described with mesh, components separation, and autologous tissue transfer.
   Conclusion: Reconstructing the infected abdomen, both temporarily and definitively, can be accomplished with various techniques, each of which is associated with unique advantages and disadvantages. Appropriate judgment is required to optimize surgical outcomes in these complex cases.
C1 [Turza, Kristin C.; Rosenberger, Laura H.; Politano, Amani D.; Davies, Stephen W.; Riccio, Lin M.; Sawyer, Robert G.] Univ Virginia Hlth Syst, Dept Surg, Charlottesville, VA 22908 USA.
   [Campbell, Chris A.] Univ Virginia Hlth Syst, Dept Plast & Reconstruct Surg, Charlottesville, VA 22908 USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System
RP Turza, KC (通讯作者)，Univ Virginia Hlth Syst, Dept Surg, POB 800679, Charlottesville, VA 22908 USA.
EM kt4p@virginia.edu
RI Sawyer, Robert/JXW-6900-2024
OI Sawyer, Robert/0000-0002-8155-2661; Rosenberger,
   Laura/0000-0002-6829-6747
FU NIAID NIH HHS [T32 AI078875] Funding Source: Medline
CR American Society of Colon and Rectal Surgeons, STOM SIT PROC
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NR 65
TC 16
Z9 20
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD DEC
PY 2012
VL 13
IS 6
BP 343
EP 351
DI 10.1089/sur.2012.014
PG 9
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA 061GF
UT WOS:000312835800001
PM 23216525
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Upton, D
   Stephens, D
   Andrews, A
AF Upton, D.
   Stephens, D.
   Andrews, A.
TI Patients' experiences of negative pressure wound therapy for the
   treatment of wounds: a review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE negative pressure wound therapy; wound; patients' experiences; quality
   of life; pain; stress; anxiety
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; FOURNIERS GANGRENE; LEG
   ULCERS; CARE; NPWT; MANAGEMENT; SYSTEM; IMPACT; STATE
AB center dot Objective: To review the research on patients' experiences of undergoing negative pressure wound therapy (NPWT).
   center dot Method: A literature search was carried out using the following databases: Academic Search Complete, CINAHL, PsychINFO, MEDLINE, PubMed and PsyARTICLES. The search covered the period from 2001 to 2012, using the keywords: ['negative pressure wound therapy' OR 'vacuum- assisted closure' OR 'topical negative therapy'] AND ['patients' experiences' OR 'psychological' OR 'stress' OR 'anxiety' OR 'wellbeing' OR 'pain' OR 'quality of life' OR 'physical'].
   center dot Results: Twenty-five relevant articles were included. NPWT is generally considered to be successful in reducing wound depth and facilitating healing. However, studies have highlighted a number of issues that need to be considered. For example, the type of dressing used during treatment can have a significant effect on patients' experience of pain. Furthermore, the NPWT system can cause patients to feel anxious due to both the patient and the health professional being unfamiliar with this form of treatment. It can also restrict patients' daily care and wider social life, which may result in a negative self-image and low self-esteem. Despite this, some studies have reported positive improvements to patients' quality of life. Additionally, since NPWT can lead to faster healing, any detrimental impact upon patients' wellbeing may be short-term and less prolonged than that of other treatments.
   center dot Conclusion: Compared with other treatments, there is evidence to show that NPWT can lead to faster wound healing, and a reduced frequency of dressing changes and other treatments. However, there are a number of challenges with the use of NPWT, which need to be explored further so that improvements can be made. Specifically, certain aspects of NPWT may impact negatively on patients' wellbeing, albeit short-term. Therefore, research needs to explore patients' experiences of NPWT throughout the treatment process and to consider how this can be improved to minimise any negative effects.
   center dot Declaration of interest: There were no external sources of funding for this study. The authors have no commercial or financial conflicts of interest to declare.
C1 [Upton, D.] Univ Worcester, Inst Hlth & Soc, St Johns, Worcester, England.
C3 University of Worcester
RP Upton, D (通讯作者)，Univ Worcester, Inst Hlth & Soc, St Johns, Worcester, England.
EM d.upton@worc.ac.uk
OI Upton, Dominic/0000-0002-5547-6204
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NR 41
TC 36
Z9 43
U1 0
U2 39
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2013
VL 22
IS 1
BP 34
EP 39
DI 10.12968/jowc.2013.22.1.34
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 062QX
UT WOS:000312937300007
PM 23299356
DA 2026-07-24
ER
PT J
AU Arhi, C
   El-Gaddal, A
AF Arhi, Chanpreet
   El-Gaddal, Ahmed
TI Use of a Silver Dressing for Management of an Open Abdominal Wound
   Complicated by an Enterocutaneous Fistula-From Hospital to Community
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
ID OPEN ABDOMEN
AB BACKGROUND: Management of an open abdominal wound complicated by an enterocutaneous fistula poses multiple challenges. The enterocutaneous fistula we discuss opened directly into the abdominal wound, without forming a track through skin.
   CASE: We discuss a patient who underwent a Hartmann's procedure for diverticulitis, followed by repeat laparotomies for washout. Due to the edematous bowel and ongoing sepsis, it was not possible to close the abdomen by primary closure. Negative pressure wound therapy (NPWT) has been used successfully in these circumstances. However, the position of an enterocutaneous fistula prevented application of NPWT, and a more conservative approach was used to reduce infection and enable wound closure by secondary intention.
   CONCLUSION: Owing to the presence of an enterocutaneous fistula, we applied a silver-based dressing as an alternative to NPWT. The silver-based dressing was initially applied during the patient's hospital course and continued into the community, ultimately resulting in closure of the wound and fistula.
C1 [Arhi, Chanpreet; El-Gaddal, Ahmed] Queen Elizabeth Hosp, London SE18 4QH, England.
RP El-Gaddal, A (通讯作者)，Queen Elizabeth Hosp, Stadium Rd, London SE18 4QH, England.
EM ahmed.elgaddal@nhs.net
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   Guo S, 2010, J DENT RES, V89, P219, DOI 10.1177/0022034509359125
   Jamshidi R, 2007, ARCH SURG-CHICAGO, V142, P793, DOI 10.1001/archsurg.142.8.793
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NR 14
TC 5
Z9 5
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JAN-FEB
PY 2013
VL 40
IS 1
BP 101
EP 103
DI 10.1097/WON.0b013e318279bfa5
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 063UP
UT WOS:000313027800014
PM 23277219
DA 2026-07-24
ER
PT J
AU Ashby, RL
   Dumville, JC
   Soares, MO
   McGinnis, E
   Stubbs, N
   Torgerson, DJ
   Cullum, N
AF Ashby, Rebecca L.
   Dumville, Jo C.
   Soares, Marta O.
   McGinnis, Elizabeth
   Stubbs, Nikki
   Torgerson, David J.
   Cullum, Nicky
TI A pilot randomised controlled trial of negative pressure wound therapy
   to treat grade III/IV pressure ulcers [ISRCTN69032034]
SO TRIALS
LA English
DT Article
DE Negative pressure wound therapy; Pressure ulcer; Pilot randomised
   controlled trial
ID VENOUS LEG ULCERS; QUALITY-OF-LIFE; CLINICAL-TRIAL; ULCERATION; COST; UK
AB Background: Negative pressure wound therapy (NPWT) is widely promoted as a treatment for full thickness wounds; however, there is a lack of high-quality research evidence regarding its clinical and cost effectiveness. A trial of NPWT for the treatment of grade III/IV pressure ulcers would be worthwhile but premature without assessing whether such a trial is feasible. The aim of this pilot randomised controlled trial was to assess the feasibility of conducting a future full trial of NPWT for the treatment of grade III and IV pressure ulcers and to pilot all aspects of the trial.
   Methods: This was a two-centre (acute and community), pilot randomised controlled trial. Eligible participants were randomised to receive either NPWT or standard care (SC) (spun hydrocolloid, alginate or foam dressings). Outcome measures were time to healing of the reference pressure ulcer, recruitment rates, frequency of treatment visits, resources used and duration of follow-up.
   Results: Three hundred and twelve patients were screened for eligibility into this trial over a 12-month recruitment period and 12/312 participants (3.8%) were randomised: 6 to NPWT and 6 to SC. Only one reference pressure ulcer healed (NPWT group) during follow-up (time to healing 79 days). The mean number of treatment visits per week was 3.1 (NPWT) and 5.7 (SC); 6/6 NPWT and 1/6 SC participants withdrew from their allocated trial treatment. The mean duration of follow-up was 3.8 (NPWT) and 5.0 (SC) months.
   Conclusions: This pilot trial yielded vital information for the planning of a future full study including projected recruitment rate, required duration of follow-up and extent of research nurse support required. Data were also used to inform the cost-effectiveness and value of information analyses, which were conducted alongside the pilot trial.
C1 [Ashby, Rebecca L.; Dumville, Jo C.; Torgerson, David J.] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England.
   [Soares, Marta O.] Univ York, Ctr Hlth Econ, York YO10 5DD, N Yorkshire, England.
   [McGinnis, Elizabeth] Leeds Gen Infirm, Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England.
   [Stubbs, Nikki] St Marys Hosp, NHS Leeds Community Healthcare, Leeds, W Yorkshire, England.
   [Cullum, Nicky] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester, Lancs, England.
C3 University of York - UK; University of York - UK; Leeds General
   Infirmary; University of Leeds; University of Manchester
RP Cullum, N (通讯作者)，Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester, Lancs, England.
EM nicky.cullum@manchester.ac.uk
RI McGinnis, Elizabeth/PNF-2864-2026; Dumville, Jo/O-7867-2014; Torgerson,
   David/L-4566-2019; Cullum, Nicky/F-2438-2011; Soares, Marta Ferreira
   Oliveira/HJH-3434-2023
OI Dumville, Jo/0000-0002-6546-3685; Torgerson, David/0000-0002-1667-4275;
   Cullum, Nicky/0000-0003-2631-123X; Soares, Marta Ferreira
   Oliveira/0000-0003-1579-8513; McGinnis, Elizabeth/0000-0002-2848-9149
FU Medical Research Council [G0501814]; Medical Research Council [G0501814]
   Funding Source: researchfish; MRC [G0501814] Funding Source: UKRI
FX We would like to gratefully acknowledge the participants who took part
   in this research study. We would also like to thank Research Nurse Sally
   Blundell and the nurses in NHS Leeds who were responsible for data
   collection. Thanks are also due to Una Adderley who performed the
   blinded assessment of wound photographs. This work was supported by the
   Medical Research Council (grant no. G0501814).
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NR 43
TC 32
Z9 42
U1 0
U2 20
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JUL 28
PY 2012
VL 13
AR 119
DI 10.1186/1745-6215-13-119
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 065QD
UT WOS:000313162600001
PM 22839453
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gonzaga, TA
   Endorf, FW
   Mohr, WJ
   Ahrenholz, DH
AF Gonzaga, Teresa A.
   Endorf, Frederick W.
   Mohr, William J.
   Ahrenholz, David H.
TI Novel Surgical Approach for Axillary Hidradenitis Suppurativa Using a
   Bilayer Dermal Regeneration Template: A Retrospective Case Study
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article; Proceedings Paper
CT Midwestern Burn Regional Conference
CY SEP 28-30, 2011
CL Riverside, IA
ID MANAGEMENT
AB Hidradenitis suppurativa (HS) is a chronic debilitating disease of apocrine gland-bearing skin characterized by recurrent abscesses with subsequent rupture, scarring, and draining sinus tracts, most frequently affecting the axillary, inguinal, and anogenital regions. Conservative and temporizing treatment methods have been used to treat mild to moderate disease, but wide local excision of affected tissue is necessary for advanced disease. This creates a large soft tissue defect for which there is no consensus for reconstruction. Recovery is hampered by disease recurrence, tissue necrosis, and reoperation. The authors have described in this case study an alternative surgical approach to treat severe HS. All surgical procedures were performed by dedicated burn surgeons at a regional burn center using a two-stage surgical approach. The first stage is a wide local excision of all affected axillary tissue with immediate placement of a bilayer dermal regeneration template to cover the defect. This is secured with a negative pressure wound therapy dressing. The second stage uses a thin split thickness skin graft to close the wound. Results of four patients are presented. There were no recurrences of HS. Two patients required reoperations to address granulation tissue overgrowth and small areas of autograft loss. One patient experienced skin substitute loss as a result of infection. Inadequate excision of HS is the leading cause of disease recurrence. Using a bilayer dermal regeneration template with subsequent skin graft, surgeons can be aggressive in their excision of HS, achieving satisfactory functional and cosmetic results and minimizing axillary recurrence. (J Burn Care Res 2013;34:51-57)
C1 [Gonzaga, Teresa A.; Endorf, Frederick W.; Mohr, William J.; Ahrenholz, David H.] Reg Hosp, Burn Ctr, St Paul, MN 55101 USA.
   [Endorf, Frederick W.; Mohr, William J.; Ahrenholz, David H.] Reg Hosp, Dept Trauma & Gen Surg, St Paul, MN 55101 USA.
   [Endorf, Frederick W.; Mohr, William J.; Ahrenholz, David H.] Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities
RP Gonzaga, TA (通讯作者)，Reg Hosp, Burn Ctr, 640 Jackson St, St Paul, MN 55101 USA.
CR Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
   Gottlieb M, 2005, MANAGEMENT COMPLEX P
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   YU CCW, 1990, BRIT J DERMATOL, V122, P763
NR 18
TC 25
Z9 27
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2013
VL 34
IS 1
BP 51
EP 57
DI 10.1097/BCR.0b013e31826a7be7
PG 7
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Dermatology; Surgery
GA 068IH
UT WOS:000313359400018
PM 23128139
DA 2026-07-24
ER
PT J
AU Li, JQ
   Topaz, M
   Tan, H
   Li, YJ
   Li, WZ
   Xun, WX
   Yuan, YQ
   Chen, SZ
   Li, XY
AF Li, Jinqing
   Topaz, Morris
   Tan, Hong
   Li, Yuejun
   Li, Wangzhou
   Xun, Wenxing
   Yuan, Yanqin
   Chen, Shaozong
   Li, Xueyong
TI Treatment of Infected Soft Tissue Blast Injury in Swine by Regulated
   Negative Pressure Wound Therapy
SO ANNALS OF SURGERY
LA English
DT Article
DE blast injury; infection; regulated negative pressure wound therapy;
   wound healing
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   ULCERS; MULTICENTER
AB Objective: This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected blast injuries in swine.
   Background: Approximately 30% to 80% of blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries.
   Methods: Infected soft tissue blast injuries were treated with gauze dressings or RNPT with different pressures ranging from -5 to -35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the blast injury, the bacterial load, bacterial species, and several inflammatory markers were detected.
   Results: Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from -10 to -25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue blast injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group.
   Conclusions: RNPT clearly shows beneficial effects in treating the infected soft tissue blast injury in comparison with the gauze dressing therapy in swine.
C1 [Li, Jinqing; Li, Yuejun; Li, Wangzhou; Xun, Wenxing; Yuan, Yanqin; Chen, Shaozong; Li, Xueyong] Fourth Mil Med Univ, Tangdu Hosp, Dept Plast & Burn Surg, Xian 710038, Peoples R China.
   [Topaz, Morris] Hillel Yaffe Med Ctr, Plast Surg Unit, Hadera, Israel.
   [Tan, Hong] Univ Colorado, Cell & Dev Biol Dept, Aurora, CO USA.
C3 Air Force Medical University; University of Colorado System; University
   of Colorado Anschutz
RP Li, XY (通讯作者)，Fourth Mil Med Univ, Tangdu Hosp, Dept Plast & Burns, Xian 710038, Peoples R China.
EM yuy-ong@fmmu.edu.cn
RI Li, Jinqing/A-2334-2013
OI Li, Jinqing/0000-0003-4635-2661; Tan, Hong/0000-0002-8660-8222
FU National Natural Science grants [81071570, 30872679]
FX Supported by National Natural Science grants (81071570 and 30872679).
   The authors declare that they have nothing to disclose.
CR [Anonymous], 105 GEN M AM SOC MIC
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NR 32
TC 27
Z9 31
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD FEB
PY 2013
VL 257
IS 2
BP 335
EP 344
DI 10.1097/SLA.0b013e318269d1ca
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 068IX
UT WOS:000313361300024
PM 23108116
DA 2026-07-24
ER
PT J
AU Anesäter, E
   Borgquist, O
   Torbrand, C
   Roupe, KM
   Ingemansson, R
   Lindstedt, S
   Malmsjö, M
AF Anesater, Erik
   Borgquist, Ola
   Torbrand, Christian
   Roupe, K. Markus
   Ingemansson, Richard
   Lindstedt, Sandra
   Malmsjo, Malin
TI A Rigid Disc for Protection of Exposed Blood Vessels During Negative
   Pressure Wound Therapy
SO SURGICAL INNOVATION
LA English
DT Article
DE experimental surgery; wound healing; negative pressure wound therapy;
   microvascular blood flow
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   FLOW; EXPERIENCE
AB Background. There are increasing reports of serious complications and deaths associated with negative pressure wound therapy (NPWT). Bleeding may occur when NPWT is applied to a wound with exposed blood vessels. Inserting a rigid disc in the wound may protect these structures. The authors examined the effects of rigid discs on wound bed tissue pressure and blood flow through a large blood vessel in the wound bed during NPWT. Methods. Wounds were created over the femoral artery in the groin of 8 pigs. Rigid discs were inserted. Wound bed pressures and arterial blood flow were measured during NPWT. Results. Pressure transduction to the wound bed was similar for control wounds and wounds with discs. Blood flow through the femoral artery decreased in control wounds. When a disc was inserted, the blood flow was restored. Conclusions. NPWT causes hypoperfusion in the wound bed tissue, presumably as a result of mechanical deformation. The insertion of a rigid barrier alleviates this effect and restores blood flow.
C1 [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, SE-22184 Lund, Sweden.
   [Anesater, Erik; Borgquist, Ola; Torbrand, Christian; Roupe, K. Markus; Ingemansson, Richard; Lindstedt, Sandra; Malmsjo, Malin] Skane Univ Hosp, SE-22184 Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital
RP Malmsjö, M (通讯作者)，Lund Univ, Dept Ophthalmol, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Lindstedt, Sandra/AEM-2892-2022; Roupé, Markus/K-6502-2014; Torbrand,
   Christian/HIZ-8092-2022; Borgquist, Ola/AAO-6451-2020
OI Lindstedt, Sandra/0000-0003-4484-6473; Ingemansson,
   Richard/0000-0001-7623-8953; Roupé, Markus/0000-0001-5472-8134; Maljö,
   Malin/0000-0001-9849-9599; Torbrand, Christian/0000-0001-6442-7554; 
FU Swedish Medical Research Council; Lund University Faculty of Medicine;
   Swedish Government Grant for Clinical Research; Lund University Hospital
   Research Grants; Swedish Medical Association; Royal Physiographic
   Society in Lund; Ake Wiberg Foundation; Anders Otto Sward
   Foundation/Ulrika Eklund Foundation; Magn Bergvall Foundation; Crafoord
   Foundation; Anna-Lisa and Sven-Erik Nilsson Foundation; Jeansson
   Foundation; Swedish Heart-Lung Foundation; Anna and Edvin Berger's
   Foundation; Marta Lundqvist Foundation; Lars Hierta Memorial Foundation
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   supported by the Swedish Medical Research Council, Lund University
   Faculty of Medicine, the Swedish Government Grant for Clinical Research,
   Lund University Hospital Research Grants, the Swedish Medical
   Association, the Royal Physiographic Society in Lund, the Ake Wiberg
   Foundation, the Anders Otto Sward Foundation/Ulrika Eklund Foundation,
   the Magn Bergvall Foundation, the Crafoord Foundation, the Anna-Lisa and
   Sven-Erik Nilsson Foundation, the Jeansson Foundation, the Swedish
   Heart-Lung Foundation, Anna and Edvin Berger's Foundation, the Marta
   Lundqvist Foundation, and the Lars Hierta Memorial Foundation.
CR Bapat V, 2008, J CARDIAC SURG, V23, P227, DOI 10.1111/j.1540-8191.2008.00595.x
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   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
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   Petzina R, 2010, J THORAC CARDIOV SUR, V140, P1133, DOI 10.1016/j.jtcvs.2010.06.063
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   U.S. Food and Drug Administration, 2009, FDA PREL PUBL HLTH N
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
NR 20
TC 1
Z9 1
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD FEB
PY 2013
VL 20
IS 1
BP 74
EP 80
DI 10.1177/1553350612444169
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 068JF
UT WOS:000313362300010
PM 22517331
DA 2026-07-24
ER
PT J
AU Pauchot, J
   Elkhyat, A
   Rolin, G
   Mac, S
   Grumblat, A
   Fotso, A
   Humbert, P
   Tropet, Y
AF Pauchot, Julien
   Elkhyat, Ahmed
   Rolin, Gwenael
   Mac, Sophie
   Grumblat, Anne
   Fotso, Arnaud
   Humbert, Philippe
   Tropet, Yves
TI Dermal Equivalents in Oncology: Benefit of One-Stage Procedure
SO DERMATOLOGIC SURGERY
LA English
DT Article
ID ARTIFICIAL DERMIS; RECONSTRUCTIVE SURGERY; SUBATMOSPHERIC PRESSURE;
   REGENERATION TEMPLATE; CLINICAL-TRIAL; INTEGRA; SKIN; DEFECTS; BURNS;
   MATRIDERM(R)
AB Background In oncology, dermal equivalent may be indicated to cover losses of substance related to skin tumors or after the removal of skin flaps. Objective To report our experience of two dermal equivalents, Matriderm 1 mm with a one-stage graft (DE1) and Integra DL with a two-stage graft (DE2) in oncology. Patients and Method Retrospective, single-center study involving 16 patients. Results Sixteen patients received dermal equivalents as an alternative to flaps (7 cases), over tendinous areas (7 cases), and for cosmetic purposes (2 cases). Twelve patients received DE1 and four DE2. Wound healing times with DE1 were 4 weeks less than those with DE2. Three cases of infection were noted with DE2. The use of dermal equivalents as an alternative to skin flaps was effective, and no adhesions were found over the tendinous areas. Conclusion The learning curve, the two-stage graft required with DE2, and not using a vacuum-assisted closure system can explain the high infection rate. The use of dermal equivalents is particularly indicated in the treatment of skin defect in oncology. The possibility of a one-stage graft with DE1 and combination with negative pressure therapy is beneficial.
C1 [Pauchot, Julien; Tropet, Yves] Univ Hosp Besancon, Orthopaed Traumatol Plast Reconstruct & Hand Surg, F-25030 Besancon, France.
   [Pauchot, Julien] Univ Franche Comte, Res Unit EA IFR INSERM 4268 I4S 133, F-25030 Besancon, France.
   [Elkhyat, Ahmed; Humbert, Philippe] Univ Hosp Besancon, Dept Dermatol, F-25030 Besancon, France.
   [Elkhyat, Ahmed; Rolin, Gwenael; Humbert, Philippe] Univ Hosp Besancon, Res Unit IBC, F-25030 Besancon, France.
   [Rolin, Gwenael] Univ Hosp Besancon, Clin Invest Ctr Besancon, F-25030 Besancon, France.
   [Mac, Sophie] Univ Hosp Besancon, Skinexigence SAS, F-25030 Besancon, France.
   [Grumblat, Anne] Univ Hosp Besancon, CAMSP, F-25030 Besancon, France.
   [Fotso, Arnaud] Univ Hosp Besancon, Dept Pediat Surg, F-25030 Besancon, France.
C3 Universite Marie et Louis Pasteur; CHU Besancon; Universite Marie et
   Louis Pasteur; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Marie et Louis Pasteur; CHU Besancon; Universite
   Marie et Louis Pasteur; CHU Besancon; Universite Marie et Louis Pasteur;
   CHU Besancon; Universite Marie et Louis Pasteur; CHU Besancon;
   Universite Marie et Louis Pasteur; CHU Besancon; Universite Marie et
   Louis Pasteur; CHU Besancon
RP Pauchot, J (通讯作者)，Univ Hosp Besancon, Orthopaed Traumatol Plast Reconstruct & Hand Surg, Pl St Jacques, F-25030 Besancon, France.
EM jpauchot@chu-besancon.fr
RI ROLIN, Gwenaël/ABE-1820-2021
OI ROLIN, Gwenaël/0000-0002-6234-869X
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NR 23
TC 10
Z9 11
U1 0
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1076-0512
J9 DERMATOL SURG
JI Dermatol. Surg.
PD JAN
PY 2013
VL 39
IS 1
BP 43
EP 50
DI 10.1111/dsu.12044
PN 1
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 071KJ
UT WOS:000313591100005
PM 23190429
DA 2026-07-24
ER
PT J
AU Everett, CB
   Thomas, BW
   Moncure, M
AF Everett, Christopher B.
   Thomas, Bruce W.
   Moncure, Michael
TI Internal vacuum-assisted closure device in the swine model of severe
   liver injury
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Liver trauma; Negative-pressure therapy; Swine model; Hemorrhage
ID FIBRIN SEALANT DRESSINGS; REDUCE BLOOD-LOSS; INTRAABDOMINAL PRESSURE;
   HEPATIC-INJURY; VENOUS HEMORRHAGE; FASCIAL CLOSURE; DAMAGE CONTROL;
   MANAGEMENT; SURVIVAL; PACKING
AB Objectives: The authors present a novel approach to nonresectional therapy in major hepatic trauma utilizing intraabdominal perihepatic vacuum assisted closure (VAC) therapy in the porcine model of Grade V liver injury.
   Methods: A Grade V injury was created in the right lobe of the liver in a healthy pig. A Pringle maneuver was applied (4.5 minutes total clamp time) and a vacuum assisted closure device was placed over the injured lobe and connected to suction. The device consisted of a perforated plastic bag placed over the liver, followed by a 15 cm by 15cm VAC sponge covered with a nonperforated plastic bag. The abdomen was closed temporarily. Blood loss, cardiopulmonary parameters and bladder pressures were measured over a one-hour period. The device was then removed and the animal was euthanized.
   Results: Feasibility of device placement was demonstrated by maintenance of adequate vacuum suction pressures and seal. VAC placement presented no major technical challenges. Successful control of ongoing liver hemorrhage was achieved with the VAC. Total blood loss was 625 ml (20ml/kg). This corresponds to class II hemorrhagic shock in humans and compares favorably to previously reported estimated blood losses with similar grade liver injuries in the swine model. No post-injury cardiopulmonary compromise or elevated abdominal compartment pressures were encountered, while hepatic parenchymal perfusion was maintained.
   Conclusion: These data demonstrate the feasibility and utility of a perihepatic negative pressure device for the treatment of hemorrhage from severe liver injury in the porcine model.
C1 [Everett, Christopher B.; Thomas, Bruce W.] Univ Kansas, Sch Med, Dept Surg, Wichita, KS 67214 USA.
   [Moncure, Michael] Univ Kansas, Med Ctr, Dept Surg, Kansas City, KS 66103 USA.
C3 University of Kansas; University of Kansas Medical Center; University of
   Kansas; University of Kansas Medical Center
RP Thomas, BW (通讯作者)，Univ Kansas, Sch Med, Dept Surg, 929 N St Francis St, Wichita, KS 67214 USA.
EM forfeem@gmail.com
FU Kansas University Medical Center; Wesley Medical Center Trauma Research
   Fund
FX This study was funded in part by funds from the Kansas University
   Medical Center, and the Wesley Medical Center Trauma Research Fund.
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NR 39
TC 1
Z9 1
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD DEC 5
PY 2012
VL 7
AR 38
DI 10.1186/1749-7922-7-38
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 073BF
UT WOS:000313717500001
PM 23217091
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Shweiki, E
   Gallagher, KE
AF Shweiki, Ehyal
   Gallagher, Kathy E.
TI Negative pressure wound therapy in acute, contaminated wounds:
   documenting its safety and efficacy to support current global practice
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Contaminated; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; MANAGEMENT; EXPERIENCE;
   DRESSINGS; SYSTEM; AMPUTATION; CARE
AB Negative pressure wound therapy (NPWT) is in widespread use and its role in wound care is expanding worldwide. It is estimated that 300 million acute wounds are treated globally each year. Currently, sporadic data exist to support NPWT in acutely contaminated wounds. Despite lack of data, use of negative pressure wound therapy in such cases is increasing across the globe. We retrospectively reviewed 86 consecutive patients, totalling 97 contaminated wounds. All wounds were Class IV based on US Center for Disease Control criteria. Sepsis criteria were present in 78/86 (91%) of patients. All patients were managed with NPWT. Wound type, degree of tissue destruction, presence of infection, wound dimension, timing of initial NPWT, type and timing of wound closure and patient comorbidities were recorded. Outcome endpoints included durability of wound closure and death. Wound location was 41/97 (42%) in the torso; 56/97 (58%) at the extremities. Tissue necrosis was present in 84/97 (87%) of wounds. Infection was present in 86/97 (89%) of wounds. Average wound size was 619 cm2 when square surface area measured; 786 cm3 when volume measurements taken. Mean time to wound closure was 17 days, median 10 days and mode 6 days. Durability of wound closure 73/79 (92%). Deaths were noted in 6/86 (7%) of patients. No deaths appeared related to NPWT. Contemporary NPWT related acute wound care is expanding empirically, in quantity and scope across the globe. However, several areas of concern are known regarding this contemporary use of NPWT in acute wounds. Thus, it is important to assess the safety and efficacy of such expanded empiric NPWT practice. Based on our findings with NPWT in the largest known patient cohort of this type, NPWT appears safe and effective in managing acute, contaminated wounds including patients meeting sepsis criteria. These findings provide evidence-based support for current worldwide empiric NPWT-related acute wound care.
C1 [Shweiki, Ehyal] Thomas Jefferson Univ Hosp, Dept Surg, Philadelphia, PA 19107 USA.
   [Gallagher, Kathy E.] Christiana Care Hlth Syst, Dept Surg, Newark, DE 19713 USA.
C3 Thomas Jefferson University; Christiana Care Health System
RP Gallagher, KE (通讯作者)，Christiana Care Hlth Syst, Dept Surg, MAP2 Suite 3301, Newark, DE 19713 USA.
EM KaGallagher@christianacare.org
CR [Anonymous], 2010, NEG PRESS WOUND THER
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NR 40
TC 21
Z9 24
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2013
VL 10
IS 1
BP 13
EP 43
DI 10.1111/j.1742-481X.2012.00940.x
PG 31
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 073MK
UT WOS:000313746900005
PM 22420782
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Powers, AK
   Neal, MT
   Argenta, LC
   Wilson, JA
   DeFranzo, AJ
   Tatter, SB
AF Powers, Alexander K.
   Neal, Matthew T.
   Argenta, Louis C.
   Wilson, John A.
   DeFranzo, Anthony J.
   Tatter, Stephen B.
TI Vacuum-assisted closure for complex cranial wounds involving the loss of
   dura mater
SO JOURNAL OF NEUROSURGERY
LA English
DT Article
DE complex scalp wound; vacuum-assisted closure; surgical technique
ID RANDOMIZED CONTROLLED-TRIAL; SUBATMOSPHERIC PRESSURE; RECONSTRUCTIVE
   SURGERY; NECK RECONSTRUCTION; SKIN-GRAFTS; THERAPY; MANAGEMENT; SYSTEM;
   HEAD; INTEGRA
AB The aim in this study was to describe the safety and efficacy of vacuum-assisted closure (VAC) in patients with complex cranial wounds with extensive scalp, bone, and dural defects who were not candidates for immediate free tissue transfer. Five patients (4 men and 1 woman) ages 24-73 years with complex cranial wounds were treated with VAC at Wake Forest Baptist Medical Center. Etiologies included trauma, squamous cell carcinoma, and malignant meningioma. Cutaneous wound defects measured as large as 15 cm in diameter. Four of the 5 patients had open skull defects with concomitant dural defects, and 1 patient had dural dehiscence. After surgical debridement, all 5 patients were treated with the direct application of a VAC device to a reapproximated dura mater (1 patient), to a pericranial flap (1 patient), or to a regenerative tissue matrix overlying CNS tissue (3 patients). In all cases involving open cranial wounds, the VAC device promoted granulation tissue formation over the dural substitute, prevented CSF leakage, and kept the wounds free from local infection. The duration of VAC therapy ranged from 16 to 91 days. Although VAC therapy was intended as a temporary measure until these patients could be stabilized for larger tissue transfer procedures or they succumbed to their primary pathology, 1 patient had a successful skin graft following VAC therapy. Hydrocephalus requiring shunt placement developed in 2 patients during VAC therapy. The VAC dressings applied to a tissue matrix or other barrier over brain tissue in extensive cranial wounds are safe and well tolerated, providing a functional barrier and preventing infection. (http://thejns.org/doi/abs/10.3171/2012.10.JNS112241)
C1 [Powers, Alexander K.; Neal, Matthew T.; Wilson, John A.; Tatter, Stephen B.] Wake Forest Univ, Bowman Gray Sch Med, Dept Neurosurg, Winston Salem, NC 27157 USA.
   [Argenta, Louis C.; DeFranzo, Anthony J.] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University; Wake Forest Baptist Medical Center
RP Powers, AK (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Neurosurg, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM apowers@wfubmc.edu
RI Tatter, Stephen/AAD-6524-2021
OI Tatter, Stephen/0000-0002-1063-0431
FU KCI
FX Wake Forest University has patents pertaining to the VAC device and
   receives royalties from KCI for the device. Dr. Argenta receives a
   portion of these royalties by university policy.
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   Yuan-Innes M J, 2001, Spine (Phila Pa 1976), V26, pE30
NR 44
TC 23
Z9 30
U1 0
U2 8
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 0022-3085
J9 J NEUROSURG
JI J. Neurosurg.
PD FEB
PY 2013
VL 118
IS 2
BP 302
EP 308
DI 10.3171/2012.10.JNS112241
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 076DY
UT WOS:000313937900012
PM 23157181
DA 2026-07-24
ER
PT J
AU Phan, TQV
   Depner, C
   Theodorou, P
   Lefering, R
   Perbix, W
   Spilker, G
   Weinand, C
AF Phan, Truong Q. V.
   Depner, Christian
   Theodorou, Panagiotis
   Lefering, Rolf
   Perbix, Walter
   Spilker, Gerald
   Weinand, Christian
TI Failure of Secondary Wound Closure After Sternal Wound Infection
   Following Failed Initial Operative Treatment Causes and Treatment
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE deep sternal wound infection; gram-negative bacteria; wound dehiscence;
   salvage flap closure
ID OPEN-HEART SURGERY; CARDIAC-SURGERY; MUSCLE FLAPS; RISK-FACTORS;
   POSTOPERATIVE MEDIASTINITIS; RECONSTRUCTION; TRANSPOSITION; SURVIVAL;
   COMPLICATIONS; EXPERIENCE
AB Background: Patients transferred to Plastic Surgery Departments for sternum osteomyelitis have a high morbidity of about 3%. Despite several known options for sternal wound coverage and salvage operations, wound dehiscence or wound necrosis can occur, increasing patient morbidity.
   Patients and Methods: One hundred thirty-five patients admitted between January 2007 and December 2010 were evaluated in a retrospective study for wound dehiscence after salvage-wound coverage at our institution. Various flaps were applied, such as pectoralis major myocutaneous pedicled flaps, pectoralis major muscle pedicled flaps, latissimus dorsi pedicled flaps, greater omental flaps, and vertical rectus abdominis muscle and transverse rectus abdominis muscle flaps. Inclusion criteria were sternal wound infection, bacterial wound infection, previous wound debridement outside our institution, vacuum-assisted closure device wound treatment at our institution, and secondary flap closure of the sternal defect at our institution. A multivariate regression analysis was performed.
   Results: One hundred thirty patients met the inclusion criteria. In all patients, bacterial wound colonization was shown. Forty patients showed wound dehiscence after closure at our institution. Reasons for wound dehiscence were attributed to wound size, >4 different species of bacteria colonizing the wound, gram-negative bacteria, Candida albicans, intensive care unit stay, and female gender. Interestingly, wound dehiscence was not significant correlated to obesity, smoking, atherosclerosis, renal insufficiency or type of closure influenced significantly, or necrosis.
   Conclusions: Female patients after CABG, with large sternal wounds infected with gram-negative bacteria and candida, have an 85% risk of wound dehiscence after flap coverage for sternal wound infection.
C1 Univ Hosp Cologne Merheim, Dept Plast Reconstruct & Aesthet Surg, Cologne, Germany.
   Univ Hosp Cologne Merheim, Inst Res Operat Med IFOM, Cologne, Germany.
   Univ Cologne, Dept Cardiothorac Surg, D-50931 Cologne, Germany.
   Univ Dusseldorf, Dept Cardiovasc Surg, D-40225 Dusseldorf, Germany.
C3 University of Cologne; University of Cologne; University of Cologne;
   Heinrich Heine University Dusseldorf
RP Weinand, C (通讯作者)，Univ Klin Standort Koln Merheim, Dept Plast Reconstruct & Aesthet Surg, Ostmerheimer Str 200, D-51109 Cologne, Germany.
EM phant@kliniken-koeln.de; weinandc@kliniken-koeln.de
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NR 35
TC 16
Z9 19
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2013
VL 70
IS 2
BP 216
EP 221
DI 10.1097/SAP.0b013e31823b67ec
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 076NW
UT WOS:000313964300020
PM 22274149
DA 2026-07-24
ER
PT J
AU Ganz, OM
   Gumener, R
   Gervaz, P
   Schwartz, J
   Pittet-Cuénod, B
AF Ganz, Oanna Meyer
   Gumener, Raphael
   Gervaz, Pascal
   Schwartz, Julien
   Pittet-Cuenod, Brigitte
TI Management of unusual genital lymphedema complication after Fournier's
   gangrene: a case report
SO BMC SURGERY
LA English
DT Article
DE Fournier's gangrene; Penile lymphedema; Negative pressure wound therapy;
   Perineal reconstruction
ID MYOFASCIOCUTANEOUS ADVANCEMENT FLAP; SINGLE-STAGE RECONSTRUCTION;
   PERINEAL DEFECTS
AB Background: Fournier's gangrene is a bacterial infection characterized by necrotizing fasciitis, skin and soft tissue involvement, and eventually myositis of the perineal region. Aggressive debridement of devitalized tissue and overlying skin is of paramount importance, but often leaves large defects to be reconstructed. The present case reports successful extensive perineal defects coverage following Fournier's gangrene and management of subsequent penile lymphoedema impairing sexual function in a young patient.
   Case presentation: Following perianal abscess drainage, a healthy young man presented with scrotal pain. Fournier's gangrene was diagnosed and treated with multiple surgical debridements. Tissue excision extended through the entire perineal area, base of the penile shaft, lower abdominal region, the inner thighs, and gluteal region, corresponding to 12% of the total body surface area. After serial debridements and negative pressure dressings, the defect was covered by two stages of skin grafting. Graft take was 90%. Healing was achieved without hypertrophic or retractile scar. However, chronic penile lymphedema remained and was first treated with compressive garments for 2 years. Upon failure of this conservative approach, we performed a circumcision, but only a "penile lift" allowed a satisfactory esthetical and functional result.
   Conclusion: Fournier's gangrene can be complicated by a chronic lymphedema of the penis. Conservative treatment is likely to fail in severe cases and can be treated surgically by "penile lift".
C1 [Ganz, Oanna Meyer; Gumener, Raphael; Pittet-Cuenod, Brigitte] Geneva Univ Hosp & Med Sch, Div Plast Reconstruct & Aesthet Surg, CH-1211 Geneva 14, Switzerland.
   [Gervaz, Pascal] Geneva Univ Hosp & Med Sch, Dept Surg, CH-1211 Geneva 14, Switzerland.
   [Schwartz, Julien] Geneva Univ Hosp & Med Sch, Div Urol, CH-1211 Geneva 14, Switzerland.
RP Ganz, OM (通讯作者)，Geneva Univ Hosp & Med Sch, Div Plast Reconstruct & Aesthet Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM oanna.meyer@hcuge.ch
OI Gervaz, Pascal/0000-0001-6926-8134
CR Binder JP, 2007, TECHNIQUES CHIRURGIC
   Cuccia G, 2009, UROL INT, V82, P426, DOI 10.1159/000218532
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NR 11
TC 2
Z9 2
U1 1
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD DEC 23
PY 2012
VL 12
AR 26
DI 10.1186/1471-2482-12-26
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 077UD
UT WOS:000314052800001
PM 23259537
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Christensen, TJ
   Thorum, T
   Kubiak, EN
AF Christensen, Thomas J.
   Thorum, Troy
   Kubiak, Erik N.
TI Lidocaine Analgesia for Removal of Wound Vacuum-Assisted Closure
   Dressings: A Randomized Double-Blinded Placebo-Controlled Trial
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE wound vacuum-assisted closure dressing; soft-tissue management; pain
   management
ID PRESSURE; MANAGEMENT; ANESTHESIA; SYSTEM
AB Objectives: Wound vacuum-assisted closure (VAC) is a technique used frequently by orthopedic surgeons to facilitate wound closure. Bedside VAC removal can be a source of great pain for patients, which we hypothesize can be decreased by topical lidocaine application.
   Design: This was a prospective randomized double-blinded, placebo-controlled trial (registered on clinicaltrials.gov), utilizing the crossover intervention technique.
   Setting: The study was carried out at a level 1 trauma center.
   Patients/Participants: Nondiabetic, adult patients requiring at least 2 extremity wound VAC dressing changes were involved.
   Intervention: In a double-blinded fashion, topical lidocaine (1%) was compared with topical normal saline (0.9% NaCl) after injection into the VAC sponge. The crossover intervention technique, wherein each patient received an independent VAC change with lidocaine and saline, served to control for all possible patient characteristics. Randomization determined which sample was given first or second.
   Main Outcome Measurements: The patients were evaluated for visual analog pain scores, narcotic requirement, and wound characteristics.
   Results: A total of 11 patients were enrolled for a total of 21 VAC changes (mean wound size 133 cm(2)); 1 patient withdrew after his first VAC dressing was changed with saline. Controlling for pre-VAC change pain, the lidocaine intervention was associated with 2.4 points less on the 0-10 visual analog scale for pain (P value <0.001, -3.0 to -1.7) and 1.7 mg less morphine-equivalents administered (P value <0.001, -2.3 to -1.1) during the VAC sponge removal.
   Conclusions: The patients undergoing an extremity wound VAC dressing removal at the bedside should be pretreated with topical lidocaine because it decreases pain and narcotic requirements.
C1 [Christensen, Thomas J.; Thorum, Troy; Kubiak, Erik N.] Univ Utah, Dept Orthopaed Surg, Salt Lake City, UT USA.
C3 Utah System of Higher Education; University of Utah
RP Kubiak, EN (通讯作者)，590 Wakara Way, Salt Lake City, UT 84108 USA.
EM erik.kubiak@hsc.utah.edu
FU NIH National Center for Research Resources [5UL1 RR025764]
FX The statistical analysis was supported by grant number 5UL1 RR025764
   from the NIH National Center for Research Resources.
CR Argenta PA, 2002, OBSTET GYNECOL, V99, P497, DOI 10.1016/S0029-7844(01)01752-5
   Ayoub C, 2007, GASTROINTEST ENDOSC, V66, P786, DOI 10.1016/j.gie.2007.03.1086
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NR 26
TC 18
Z9 32
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD FEB
PY 2013
VL 27
IS 2
BP 107
EP 112
DI 10.1097/BOT.0b013e318251219c
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 077VV
UT WOS:000314058300014
PM 23343829
DA 2026-07-24
ER
PT J
AU Langfitt, M
   Webb, LX
   Onwuchuruba, C
   Callahan, M
   Smith, TL
AF Langfitt, Maxwell
   Webb, Lawrence X.
   Onwuchuruba, Cheryl
   Callahan, Michael
   Smith, Thomas L.
TI Microvascular Effects of Subatmospheric Pressure in Striated Muscle
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE topical subatmospheric pressure; vasodilation; blood flow;
   vacuum-assisted closure; microvascular permeability
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; BLOOD-FLOW; DEVICE
AB Objective Topical application of subatmospheric pressure (TASAP) promotes faster wound healing, but tissue effects are not entirely understood. This study investigated microvascular effects of TASAP in striated muscle with the hypothesis being that TASAP elicits arteriolar vasodilation and decreases interstitial accumulation of protein.
   Methods Rat cremasteric microcirculation was directly examined in two experiments utilizing a novel technique. First, TASAP was applied to the cremaster in three experimental groups and a non-TASAP control group. Arteriolar diameters were directly measured before and after TASAP. In experiment two, intravascular fluorescein isothiocyanate (FITC)-labeled albumin and topical leukotriene B-4 (LTB4) were delivered to the cremaster. Microvascular permeability was assessed by measuring the accumulation/ disappearance of FITC-albumin in the interstitial tissue.
   Results TASAP produced significant arteriolar vasodilation compared with control values. The mean maximum percent increase in diameter with TASAP was 8.70% at -2 kPa (p < 0.05), 7.16% at -4 kPa (p < 0.05), and 10.43% at -6 kPa (p < 0.01). TASAP decreased interstitial FITC-albumin by 26.3% (p < 0.008) following LTB4; the control group showed a steady increase in interstitial FITC-albumin.
   Conclusions These results support the hypothesis that TASAP elicits significant arteriolar vasodilation with a subsequent increase in blood flow as well as a decrease in interstitial protein accumulation.
C1 [Smith, Thomas L.] Wake Forest Univ, Baptist Med Ctr, Dept Orthopaed Surg, Sch Med, Winston Salem, NC 27157 USA.
   [Webb, Lawrence X.] Mercer Univ, Sch Med, Dept Orthopaed Surg, Macon, GA 31207 USA.
   [Onwuchuruba, Cheryl] Univ Tennessee, Sch Med, Dept Orthoped Surg, Knoxville, TN USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Mercer
   University; University of Tennessee System; University of Tennessee
   Health Science Center
RP Smith, TL (通讯作者)，Wake Forest Univ, Baptist Med Ctr, Dept Orthopaed Surg, Sch Med, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM tsmith@wakehealth.edu
FU NIH [5 T32HL007115-27, 5 T32HL007115-28]
FX Supported in part by the NIH Short TermResearch Training of Medical
   Students grant 5 T32HL007115-27, (M. Langfitt), 5 T32HL007115-28 (C.
   Onwuchuruba).
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NR 24
TC 3
Z9 4
U1 0
U2 1
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD FEB
PY 2013
VL 29
IS 2
BP 117
EP 123
DI 10.1055/s-0032-1329924
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 078AH
UT WOS:000314070000007
PM 23292989
DA 2026-07-24
ER
PT J
AU Berrevoet, F
   Vanlander, A
   Sainz-Barriga, M
   Rogiers, X
   Troisi, R
AF Berrevoet, F.
   Vanlander, A.
   Sainz-Barriga, M.
   Rogiers, X.
   Troisi, R.
TI Infected large pore meshes may be salvaged by topical negative pressure
   therapy
SO HERNIA
LA English
DT Article
DE Mesh; Infection; Ventral hernia; Negative pressure therapy; Vacuum
   assisted therapy; Large pore
ID VACUUM-ASSISTED CLOSURE; INCISIONAL HERNIA; REPAIR; PREVENTION;
   MANAGEMENT; WOUNDS; COMPLICATIONS; RECURRENCE
AB To evaluate the efficacy of negative pressure therapy for superficial and deep mesh infections after ventral and incisional hernia repair by a prospective monocentric observational study.
   During a 6-year period, 724 consecutive open ventral and incisional hernia repairs were performed. Pre- and intraoperative data as well as postoperative complications were prospectively recorded. In case of wound infection, negative pressure therapy (NPT) was our primary treatment.
   Sixty-three patients (8.7 %) were treated using negative pressure therapy after primary ventral and incisional hernia repair. Infectious complications needing NPT occurred in 54 patients in the retromuscular group (54/523; 10.3 %), none when laparoscopically treated and in 9 patients (9/143; 6.3 %) treated by an open intraperitoneal mesh technique. Considering outcome, all meshes were completely salvaged in the retromuscular mesh group after a median of 5 dressing changes (range, 2-9), while in the intraperitoneal mesh, group 3 meshes needed complete (n = 2) or partial (n = 1) excision. Mean duration to complete wound closure was 44 days (range, 26-63 days).
   NPT is a useful adjunct for salvage of deep infected meshes, particularly when large pore monofilament mesh is used.
C1 [Berrevoet, F.; Vanlander, A.; Sainz-Barriga, M.; Rogiers, X.; Troisi, R.] Ghent Univ Hosp & Med Sch, Dept Gen & Hepatobiliary Surg, B-9000 Ghent, Belgium.
   [Berrevoet, F.; Vanlander, A.; Sainz-Barriga, M.; Rogiers, X.; Troisi, R.] Ghent Univ Hosp & Med Sch, Liver Transplantat Serv, B-9000 Ghent, Belgium.
C3 Ghent University; Ghent University Hospital; Ghent University; Ghent
   University Hospital
RP Berrevoet, F (通讯作者)，Ghent Univ Hosp & Med Sch, Dept Gen & Hepatobiliary Surg, De Pintelaan 185 2K12 IC, B-9000 Ghent, Belgium.
EM Frederik.Berrevoet@ugent.be
RI Sainz-Barriga, Mauricio/A-6456-2009; Troisi, Roberto/E-8737-2015;
   Berrevoet, Frederik/A-6117-2008; Vanlander, Aude/AAP-3342-2021
OI Sainz-Barriga, Mauricio/0000-0002-9981-4340; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Arvidsson D, 2005, BJS-BRIT J SURG, V92, P1085, DOI 10.1002/bjs.5137
   Aufenacker TJ, 2006, BJS-BRIT J SURG, V93, P5, DOI 10.1002/bjs.5186
   Bernard C, 2007, Hernia, V11, P315, DOI 10.1007/s10029-007-0222-7
   Berrevoet F, 2011, AM J SURG, V201, P85, DOI 10.1016/j.amjsurg.2010.01.022
   Berrevoet F, 2010, WORLD J SURG, V34, P1710, DOI 10.1007/s00268-010-0600-7
   Borgquist O, 2010, OSTOMY WOUND MANAG, V56, P60
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Carbonell AM, 2005, SURG ENDOSC, V19, P1670, DOI 10.1007/s00464-005-0103-z
   Cobb WS, 2003, AM SURGEON, V69, P784
   Deysine M, 1998, SURG CLIN N AM, V78, P1105, DOI 10.1016/S0039-6109(05)70372-8
   Heller L, 2006, AM J SURG, V191, P165, DOI 10.1016/j.amjsurg.2005.09.003
   Kercher KW, 2002, OSTOMY WOUND MANAG, V48, P44
   Klinge U, 2002, J BIOMED MATER RES, V63, P765, DOI 10.1002/jbm.10449
   Klinge U, 2002, J SURG RES, V103, P208, DOI 10.1006/jsre.2002.6358
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NR 32
TC 58
Z9 66
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD FEB
PY 2013
VL 17
IS 1
BP 67
EP 73
DI 10.1007/s10029-012-0969-3
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 081BT
UT WOS:000314291300010
PM 22836918
OA Green Published
DA 2026-07-24
ER
PT J
AU López-Cano, M
   Armengol-Carrasco, M
AF Lopez-Cano, M.
   Armengol-Carrasco, M.
TI Use of vacuum-assisted closure in open incisional hernia repair: a novel
   approach to prevent seroma formation
SO HERNIA
LA English
DT Article
DE Hernia; Seroma; Prevention
ID PREDICTORS; DEVICE
AB Frequent complications in incisional hernia surgery are re-herniation, wound infection and seroma formation. The use of subatmospheric pressure dressings such as the vacuum-assisted closure (VAC) device has been shown to be an effective way to accelerate healing of various wounds. Here, we describe the application of the VAC device as a postoperative dressing to prevent seroma formation after open incisional hernia repair.
   Three consecutive patients (63, 65 and 60 years of age, respectively) underwent incisional hernia repair. Patient body mass index was 30.9, 26.6 and 29 kg/m(2), respectively. All hernias were complex with a defect size greater than 10 cm and were repaired using the onlay technique. After suture skin closure the incision was covered with a thin VAC sponge (KCI, San Antonio, TX) that was set at -125 mm Hg and left in place for 5 days before removal.
   An abdominal CT scan performed before discharge from the hospital did not show seroma formation. Physical examination 3 months after surgery was normal with no evidence of seroma (abdominal bulge and/or fluid wave).
   This successful preliminary experience in three patients encourages the use of the VAC system in incisional hernia repair, particularly in selected patients with risk factors for seroma formation (e.g., large defects, obesity, patient comorbidities, nutritional status, number of prior abdominal incisions, etc.). Therefore, prevention of seroma formation after incisional hernia repair may be added as a novel application of the VAC device.
C1 [Lopez-Cano, M.; Armengol-Carrasco, M.] Hosp Univ Vall dHebron, Dept Surg, Abdominal Wall Unit, Barcelona 08035, Spain.
C3 Hospital Universitari Vall d'Hebron
RP López-Cano, M (通讯作者)，Hosp Univ Vall dHebron, Dept Surg, Abdominal Wall Unit, Passeig Vall dHebron 119-129, Barcelona 08035, Spain.
EM manulopez@vhebron.net
RI López-Cano, Manuel/H-2465-2011
OI López-Cano, Manuel/0000-0002-7993-9453; Armengol Carrasco,
   Manuel/0000-0002-3211-3195
CR Bendavid R, 2001, ABDOMINAL WALL HERNI, P753
   Kaafarani HMA, 2009, AM J SURG, V198, P639, DOI 10.1016/j.amjsurg.2009.07.019
   Klink CD, 2010, HERNIA, V14, P175, DOI 10.1007/s10029-009-0603-1
   Klink CD, 2010, HERNIA, V15, P69
   Korenkov M, 2001, LANGENBECK ARCH SURG, V386, P65, DOI 10.1007/s004230000182
   Poelman MM, 2010, HERNIA, V14, P369, DOI 10.1007/s10029-010-0646-3
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
NR 8
TC 21
Z9 25
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
J9 HERNIA
JI Hernia
PD FEB
PY 2013
VL 17
IS 1
BP 129
EP 131
DI 10.1007/s10029-011-0837-6
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 081BT
UT WOS:000314291300023
PM 21667262
DA 2026-07-24
ER
PT J
AU Schmedes, GW
   Banks, CA
   Malin, BT
   Srinivas, PB
   Skoner, JM
AF Schmedes, Gregg W.
   Banks, Caroline A.
   Malin, Barry T.
   Srinivas, Pamela B.
   Skoner, Judith M.
TI Massive Flap Donor Sites and the Role of Negative Pressure Wound Therapy
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article
DE free flap donor site complications; negative pressure wound therapy;
   microvascular head and neck reconstruction; massive flap donor site
   defects; scapular free tissue transfer; latissimus myocutaneous free
   tissue transfer; reconstructive surgery
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EXPERIENCE; SURGICAL INCISIONS;
   RECONSTRUCTION; NECK; HEAD; COMPLICATIONS
AB Objective. Report our experience with negative pressure wound therapy (NPWT) applied to massive scapular and latissimus free flap donor sites, in the setting of microvascular reconstruction for extensive head and neck defects.
   Study Design. Retrospective case series with chart review.
   Setting. Tertiary academic referral center.
   Subjects and Methods. Retrospective review was conducted of all patients who underwent scapular or latissimus free tissue transfer by the senior author for head and neck reconstruction, over a 5-year period (2006-2011). In addition to NPWT details, comprehensive patient data were abstracted and compiled, including demographics, operative details, hospital stay, postoperative follow-up, and donor site complications.
   Results. Ninety-four patients underwent reconstruction of extensive postablative head and neck defects using either a scapular or latissimus free flap. Mean harvested flap skin paddle size was 140 cm(2). All donor sites were closed primarily. Fifty-two patients (55%) had NPWT applied over closed donor site incisions postoperatively. The other 42 patients (45%) received only conventional incision care. Major donor site complications occurred in 12% (n = 5) of the patients who did not undergo NPWT, as compared with a 6% (n = 3) complication rate among patients in the NPWT-treated group.
   Conclusion. This is the first study to examine NPWT in the postoperative treatment of closed high-tension wounds following scapular or latissimus dorsi harvest for reconstruction of extensive head and neck defects. Our results suggest that NPWT is a safe technique in the management of massive scapular and latissimus free flap harvest sites that may decrease associated major donor wound complications.
C1 [Schmedes, Gregg W.; Banks, Caroline A.; Malin, Barry T.; Skoner, Judith M.] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
   [Srinivas, Pamela B.] Med Univ S Carolina, Dept Therapeut Serv, Charleston, SC 29425 USA.
C3 Medical University of South Carolina; Medical University of South
   Carolina
RP Skoner, JM (通讯作者)，Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,MSC 550, Charleston, SC 29425 USA.
EM skonerjm@musc.edu
CR Arcuri F, 2011, J CRANIOFAC SURG, V22, P2347, DOI [10.1097/SCS.0b013e318231e480, 10.1097/SCS.0b013e31820f7fac]
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   Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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NR 19
TC 20
Z9 25
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD DEC
PY 2012
VL 147
IS 6
BP 1049
EP 1053
DI 10.1177/0194599812459015
PG 5
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA 081CH
UT WOS:000314293000011
PM 22949007
DA 2026-07-24
ER
PT J
AU Oh, BH
   Lee, SH
   Nam, KA
   Lee, HB
   Chung, KY
AF Oh, B. H.
   Lee, S. H.
   Nam, K. A.
   Lee, H. B.
   Chung, K. Y.
TI Comparison of negative pressure wound therapy and secondary intention
   healing after excision of acral lentiginous melanoma on the foot
SO BRITISH JOURNAL OF DERMATOLOGY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; GROWTH-FACTORS; SKIN; MECHANISM
AB Background Melanoma in dark-skinned individuals often develops in an acral lentiginous fashion on the foot and wide excision usually results in a substantial defect. Various repair methods, including free flap, full-thickness skin graft and secondary intention healing (SIH), are used to repair these defects. Recently, use of negative pressure wound treatment (NPWT) has been shown to accelerate wound healing in different types of wound.
   Objectives To compare the functional and cosmetic results of NPWT and SIH in patients who underwent wide excision of melanomas on the foot.
   Methods The wound defects of 22 patients after wide excision of melanoma on the foot were treated using SIH (n = 13) or NPWT (n = 9).
   Results There was no significant difference in time to complete wound healing between the two groups. However, evaluation using the Vancouver Burn Scar Assessment Scale at the time of complete healing showed that the mean score of the NPWT group was significantly lower than that of the SIH group. The NPWT group also had significantly better results than the SIH group in terms of total score, vascularity and height of the scars. As for complications, no wound infection was encountered in the NPWT group, whereas eight of the 13 patients in SIH group had wound infections during the course of treatment despite frequent and meticulous aseptic dressing changes.
   Conclusions These results show that, despite the drawback of rather prolonged healing time, NPWT is an excellent therapeutic option for wounds after wide excision of melanoma on the foot, with acceptable functional and cosmetic outcomes.
C1 [Oh, B. H.; Lee, S. H.; Nam, K. A.] Yonsei Univ, Coll Med, Dept Dermatol, Severance Hosp,Cutaneous Biol Res Inst, Seoul, South Korea.
   [Lee, H. B.] Hallym Univ, Kangnam Sacred Heart Hosp, Dept Plast Surg, Seoul, South Korea.
   [Chung, K. Y.] Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Dept Dermatol,Severance Hosp,Cutaneous Biol Res I, Seoul, South Korea.
C3 Yonsei University; Severance Hospital; Yonsei University Health System;
   Hallym University; Yonsei University; Severance Hospital; Yonsei
   University Health System
RP Chung, KY (通讯作者)，Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Dept Dermatol,Severance Hosp,Cutaneous Biol Res I, Seoul, South Korea.
EM kychung@yuhs.ac
RI kyung ae, nam/HNP-9338-2023; Oh, Byung Ho/HLQ-2899-2023
OI Chung, Kee Yang/0000-0003-3257-0297; Oh, Byung Ho/0000-0001-9575-5665
CR Abe M, 2012, EUR J DERMATOL, V22, P46, DOI 10.1684/ejd.2011.1582
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   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
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   Vig S, 2011, J TISSUE VIABILITY, V20, pS1, DOI 10.1016/j.jtv.2011.07.002
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NR 29
TC 26
Z9 31
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-0963
EI 1365-2133
J9 BRIT J DERMATOL
JI Br. J. Dermatol.
PD FEB
PY 2013
VL 168
IS 2
BP 333
EP 338
DI 10.1111/bjd.12099
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 083NG
UT WOS:000314470600019
PM 23362968
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Aerden, D
   Bosmans, I
   Vanmierlo, B
   Spinnael, J
   Keymeulen, B
   Van den Brande, P
AF Aerden, D.
   Bosmans, I.
   Vanmierlo, B.
   Spinnael, J.
   Keymeulen, B.
   Van den Brande, P.
TI Skin grafting the contaminated wound bed: reassessing the role of the
   preoperative swab
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE wound culture; split thickness skin grafting; negative wound pressure
   therapy; wound bed preparation
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT; SUCCESS; INFECTIONS; DRESSINGS;
   SURFACE
AB Objective: To investigate use of the preoperative wound swab to predict graft failure compared with establishing the indication for skin grafting on clinical grounds alone.
   Method: Patients requiring meshed split-thickness skin grafting were prospectively included; the indication for grafting was established on clinical grounds exclusively. A preoperative swab of the wound bed was taken, but its result was concealed to prevent it influencing clinical decision-making. Negative pressure wound therapy (NPWT) was used for both wound bed preparation and graft fixation. After 2 months, graft area take percentage was measured using digital image processing software and the results validated against the result of the preoperative wound swab.
   Results: Eighty-seven wounds were included in the study. Mean graft area take percentage was 88%, with five grafts considered complete failures (< 25% take). A posteriori analysis of the wound cultures showed that 53% had been contaminated on grafting, but these did not fare any worse than near-sterile wounds. Qualitative analysis of cultures showed that wounds containing either Pseudomonas aeruginosa or Staphylococcus aureus did have inferior outcome (mean take percentage 78.9% vs 91.3%; p=0.038). Diabetes was also a deteriorating factor (mean take percentage 83.0% vs 90.7%; p=0.004).
   Conclusion: Establishing the indication for skin grafting on clinical grounds exclusively does not yield grossly inferior results. In light of recent advances in skin grafting, including use of NPWT as adjuvant therapy, the requirement for routine preoperative wound swabs may be questioned.
   Declaration of interest: There were no external sources of funding for this study. The authors have no conflicts of interest to declare.
C1 [Aerden, D.; Bosmans, I.; Van den Brande, P.] Univ Hosp Brussels, Dept Vasc Surg, Brussels, Belgium.
   [Aerden, D.; Vanmierlo, B.; Keymeulen, B.] Univ Hosp Brussels, Diabet Foot Clin, Brussels, Belgium.
   [Spinnael, J.] Univ Hosp Brussels, Dept Plast Surg, Brussels, Belgium.
   [Spinnael, J.] Univ Hosp Brussels, Wound Care Clin, Brussels, Belgium.
C3 Universite Libre de Bruxelles; University Hospital Brussels; University
   Hospital Brussels; University Hospital Brussels; University Hospital
   Brussels
RP Aerden, D (通讯作者)，Univ Hosp Brussels, Dept Vasc Surg, Brussels, Belgium.
EM isabelle.bosmans@uzbrussel.be
RI ; Aerden, Dimitri/AAM-5294-2021
OI Keymeulen, Bart/0000-0002-8671-4527; Aerden, Dimitri/0000-0001-5384-6147
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NR 20
TC 15
Z9 18
U1 0
U2 15
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2013
VL 22
IS 2
BP 85
EP 89
DI 10.12968/jowc.2013.22.2.85
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 085CL
UT WOS:000314589200011
PM 23665663
DA 2026-07-24
ER
PT J
AU Künzel, RA
   Marathovouniotis, N
   Kellner, MW
   Boemers, TM
AF Kuenzel, R. A.
   Marathovouniotis, N.
   Kellner, M. W.
   Boemers, T. M.
TI Severe degloving injury to both feet in a child
SO UNFALLCHIRURG
LA German
DT Article
DE Degloving; Avulsion injury; Traumatology; Full-thickness graft;
   Vacuum-assisted closure therapy
ID SKIN AVULSION INJURIES; CLASSIFICATION; OPTIONS; LIMBS
AB Although rarely described, it is generally accepted that degloving injuries can successfully be treated by defatting the degloved skin and replacing it with a full-thickness graft. There have been few reports on the outcome of this reconstructive procedure in children. In this report, we describe the use of the VAC system to treat a case of degloving injury to both feet of a 4-year-old boy who was pulled into a luggage belt while standing on it.
C1 [Kuenzel, R. A.; Marathovouniotis, N.; Boemers, T. M.] Kliniken Stadt Koln GmbH, Kinderkrankenhaus Amsterdamer Str, Klin Kinderchirurg & Kinderurol, D-50735 Cologne, Germany.
   [Kellner, M. W.] Kliniken Stadt Koln GmbH, Kinderkrankenhaus Amsterdamer Str, Abt Kinderradiol, D-50735 Cologne, Germany.
C3 University of Cologne; University of Cologne
RP Künzel, RA (通讯作者)，Kliniken Stadt Koln GmbH, Kinderkrankenhaus Amsterdamer Str, Klin Kinderchirurg & Kinderurol, Amsterdamer Str 59, D-50735 Cologne, Germany.
EM kuenzelr@kliniken-koeln.de
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NR 17
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
J9 UNFALLCHIRURG
JI Unfallchirurg
PD FEB
PY 2013
VL 116
IS 2
BP 171
EP 175
DI 10.1007/s00113-012-2163-6
PG 5
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 088LK
UT WOS:000314835700012
PM 22699318
DA 2026-07-24
ER
PT J
AU Crainiceanu, Z
   Olariu, S
   Bloanca, V
   Farca, I
   Bodog, F
   Matusz, P
   Bratu, T
AF Crainiceanu, Z.
   Olariu, S.
   Bloanca, V.
   Farca, I.
   Bodog, F.
   Matusz, P.
   Bratu, T.
TI Continuous Negative Pressure Wound Therapy in the Treatment of a
   Gigantic Trophic Leg Ulcer
SO CHIRURGIA
LA English
DT Article
DE trophic leg ulcers; pathologic reflux; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; CONTROLLED-TRIAL; SKIN-GRAFTS; DIAGNOSIS
AB Aim: to present a therapeutic algorithm for chronic venous insufficiency complicated with ulceration, using etiologic treatment combined with local treatment by negative pressure wound therapy (NPWT) before and after skin grafting.
   Material and method: we are discussing a 59 years-old patient with a lower leg gigantic, circumferential trophic lesion. The aetiology was combined, post-traumatic and chronic venous insufficiency, with 30 years of evolution.
   Results: the treatment was applied in two surgical steps. Initially the pathological refluxes were interrupted; secondarily a skin graft was applied, preceded and followed by NPWT until graft intake. The wound healed completely; patient developed secondary foot lymphoedema.
   Conclusions: 1. Case treatment particularity consists in using a combination of etiologic and local treatment, combined with adjuvant NPWT. 2. Secondary lymphoedema developed due to circumferential location of the lesion. 3. Continuous NPWT has proven its efficiency in chronic ulcer before and after skin grafting, reducing costs and duration of treatment.
C1 [Crainiceanu, Z.; Bloanca, V.; Matusz, P.; Bratu, T.] Victor Babes Univ Med & Pharm, Plast & Reconstruct Surg Dept, Emergency Cty Hosp, Timisoara 300736, Romania.
   [Olariu, S.; Farca, I.] Victor Babes Univ Med & Pharm, Dept Surg 1, Emergency Cty Hosp, Timisoara 300736, Romania.
   [Bodog, F.] Univ Oradea, Plast & Reconstruct Surg Dept, Oradea, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; University of Oradea
RP Olariu, S (通讯作者)，Victor Babes Univ Med & Pharm, Dept Surg 1, Emergency Cty Hosp, I Bulbuca Bvd 10, Timisoara 300736, Romania.
EM srnolariu@yahoo.com
RI /AAQ-2387-2021; Crainiceanu, Zorin/H-1362-2011; Bloanca,
   Vlad/NDT-5296-2025
OI Crainiceanu, Zorin/0000-0002-2880-7485; Bloanca,
   Vlad/0000-0002-4365-9847
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
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NR 20
TC 4
Z9 4
U1 0
U2 14
PU EDITURA CELSIUS
PI BUCHAREST
PA STR LITOVOI VOIEVOD NR 1, BL OD7A, SC A, AP 20, SECTOR 2, BUCHAREST,
   00000, ROMANIA
SN 1221-9118
EI 1842-368X
J9 CHIRURGIA-BUCHAREST
JI Chirurgia
PD JAN-FEB
PY 2013
VL 108
IS 1
BP 112
EP 115
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 092WH
UT WOS:000315153200020
PM 23464781
DA 2026-07-24
ER
PT J
AU Saraiya, HA
   Shah, MN
AF Saraiya, Hemant A.
   Shah, Mukesh N.
TI Use of Indigenously Made Negative-Pressure Wound Therapy System for
   Patients with Diabetic Foot
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative-pressure wound therapy; diabetic foot; nonhealing wounds;
   vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE; DEVICE
AB OBJECTIVE: Negative-pressure wound therapy (NPWT) is a well-known treatment modality for chronic, difficult, nonhealing wounds. Unfortunately, many commercially available negative-pressure therapy systems for wounds are expensive, require hospitalization, and may not be available throughout the world. The authors have designed a less expensive and effective NPWT system from components readily available in the hospital.
   DESIGN: The system is assembled from ethylene oxide sterilized polyurethane foam, transparent adhesive dressing, and a simple negative suction drain system, which is being routinely used in surgical cases. The multiple holes suction tube is inserted between 2 layers of polyurethane foam and is put on the wound, which is sealed by adhesive dressing. The negative pressure is created using a closed wound suction set. The dressing is changed every third day or as needed.
   MAIN RESULTS: The authors have used this system in 11 patients with diabetic foot. The mean time for preparation of wound for surgery with this system was 7 days (5-9 days). The raw areas were either secondarily closed or were covered with split-thickness skin graft. The mean hospital stay for debridement and definitive surgical procedure was 11 days (8-15 days).
   CONCLUSION: In the authors' experience, the NPWT system developed from off-the-shelf components reduces the length of hospital stays and therefore cost, without any compromise on quality. It leads to a quicker wound closure and reduces the need for multiple surgeries or flaps. This modification presents a simple, cheap, and effective alternative to commercially available NPWT machines.
C1 [Saraiya, Hemant A.] Sushrut Plast Surg Res Ctr, Ahmadabad, Gujarat, India.
   [Saraiya, Hemant A.] Gujarat Canc Res Inst, Ahmadabad, Gujarat, India.
   [Shah, Mukesh N.] GCS Med Coll, Ahmadabad, Gujarat, India.
C3 The Gujarat Cancer & Research Institute
RP Saraiya, HA (通讯作者)，Sushrut Plast Surg Res Ctr, Ahmadabad, Gujarat, India.
RI Saraiya, Hemant/JWP-9745-2024
OI Saraiya, Hemant/0000-0001-9721-6454
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NR 15
TC 6
Z9 8
U1 1
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1527-7941
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD FEB
PY 2013
VL 26
IS 2
BP 74
EP 77
DI 10.1097/01.ASW.0000426716.51702.29
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 094TN
UT WOS:000315286800006
PM 23337647
DA 2026-07-24
ER
PT J
AU Dezfuli, B
   Li, CS
   Young, JN
   Wong, MS
AF Dezfuli, Bobby
   Li, Chin-Shang
   Young, J. Nilas
   Wong, Michael S.
TI Treatment of Sternal Wound Infection with Vacuum-Assisted Closure
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID RISK-FACTORS; MEDIAN STERNOTOMY; MEDIASTINITIS; COMPLICATIONS;
   MANAGEMENT; SURGERY; THERAPY; SURVIVAL; BRIDGE; IMPACT
AB Introduction. Previous work has demonstrated the efficacy of vacuum-assisted closure (VAC) in the treatment of poststernotomy local wound infections, compared to historical treatment protocol. The negative pressure has been found to protect wounds against contamination, prevent wound fluid retention, increase blood flow, and increase rates of granulation tissue formation. For this study, a retrospective analysis compared patients receiving VAC as definitive treatment versus bridging to delayed flap closure. Methods. Sixteen patients developed sternal wound infections after cardiac surgeries at the authors' institution from 2006 to 2008. Data was gathered regarding patient comorbidities, treatment method, and outcome. Study objectives included assessment of risk factors that warranted secondary surgical closure and examination of long-term followup where VAC was the definitive treatment modality. Results. Group A (n = 12) had VAC as the final treatment modality. Group B (n = 4) required myocutaneous flap closure. One patient in Group B passed away prior to flap surgery. Both groups had similar risk factors, except Group B had a higher risk of body mass index (BMI) > 35 that was near statistically significant (P = 0.085; odds ratio = 0.0, 95% CI = [0.0 - 1.21]). Group A required a shorter hospital stay on average. Long-term follow-up showed the majority of Group A had completely healed sternal wounds 2-3 years from initial cardiac surgery. Conclusions. Vacuum-assisted closure as definitive treatment modality is a successful, first line therapy for local superficial sternal wound infections. When deep infections occur, however, VAC as bridge-to-flap coverage is recommended over attempted secondary healing with VAC.
C1 [Dezfuli, Bobby] Univ Arizona, Med Ctr, Dept Orthopaed Surg, Tucson, AZ 85719 USA.
   [Li, Chin-Shang] Univ Calif Davis, Dept Publ Hlth Sci, Div Biostat, Davis, CA 95616 USA.
   [Young, J. Nilas] UC Davis Sch Med, Dept Surg, Div Cardiothorac Surg, Sacramento, CA USA.
   [Wong, Michael S.] UC Davis Sch Med, Dept Surg, Div Plast & Reconstruct Surg, Sacramento, CA USA.
C3 University of Arizona; University of California System; University of
   California Davis; University of California System; University of
   California Davis; University of California System; University of
   California Davis
RP Dezfuli, B (通讯作者)，Univ Arizona, Med Ctr, Dept Orthopaed Surg, 1609 N Warren Ave,Suite 110,POB 245064, Tucson, AZ 85719 USA.
EM dezfuli@email.arizona.edu
FU National Center for Research Resources, a component of the National
   Institutes of Health [UL1 RR024146]; NIH Roadmap for Medical Research
FX The authors would like to acknowledge the Division of Cardiothoracic
   Surgery and Keanna Jordan from the Health Information Management
   Department at UCDMC for their help with data collection. This
   publication was made possible by Grant Number UL1 RR024146 from the
   National Center for Research Resources, a component of the National
   Institutes of Health and NIH Roadmap for Medical Research.
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NR 38
TC 1
Z9 1
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2013
VL 25
IS 2
BP 41
EP 50
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 096UM
UT WOS:000315430100005
PM 25867806
DA 2026-07-24
ER
PT J
AU Awad, T
   Butcher, M
AF Awad, T.
   Butcher, M.
TI Handling the sequelae of breast cancer treatment: use of NPWT to enhance
   patient independence
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE breast cancer; wound breakdown; negative pressure wound therapy; quality
   of life; care partnership
ID QUALITY-OF-LIFE
AB A cancer diagnosis can be an overwhelming experience and has devastating implications for an individual, their family and friends. Radical treatment, although often essential, can have its own health consequences. This case study describes the management of a 38-year-old woman with a portable, non-electrical negative pressure wound therapy device, suggesting benefits in terms of healing, patient independence and improved quality of life. The case study also highlights the importance of effective communication, patient involvement and empowerment in clinical decision-making, showing that an effective client-clinician relationship can help overcome the physical and emotional sequelae of this diagnosis.
C1 [Awad, T.] BUPA Cromwell Hosp, London, England.
   [Butcher, M.] South West Wound Care Consultancy, S Tyneside, Devon, England.
RP Awad, T (通讯作者)，BUPA Cromwell Hosp, London, England.
EM m.butcher_woundcare@hotmail.com
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NR 24
TC 5
Z9 5
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2013
VL 22
IS 3
BP 162
EP 166
DI 10.12968/jowc.2013.22.3.162
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA 098BR
UT WOS:000315519600008
PM 23665735
DA 2026-07-24
ER
PT J
AU Wedemeyer, J
   Lankisch, T
AF Wedemeyer, J.
   Lankisch, T.
TI Endoscopic vacuum-assisted closure
SO INTERNIST
LA German
DT Article
DE Anastomotic leak; Esophagus; Rectum; Vacuum-assisted closure; Drainage
ID ESOPHAGEAL ANASTOMOTIC LEAKS; PRESSURE WOUND THERAPY; ANTERIOR
   RESECTION; PLASTIC STENTS; RECTAL-CANCER; RISK-FACTORS; PANCREATITIS;
   NECROSECTOMY; PERFORATIONS; DRAINAGE
AB Anastomotic leakage in the upper and lower intestinal tract is associated with high morbidity and mortality. Within the last 10 years endoscopic treatment options have been accepted as sufficient treatment option of these surgical complications. Endoscopic vacuum assisted closure (E-VAC) is a new innovative endoscopic therapeutic option in this field. E-VAC transfers the positive effects of vacuum assisted closure (VAC) on infected cutaneous wounds to infected cavities that can only be reached endoscopically. A sponge connected to a drainage tube is endoscopically placed in the leakage and a continuous vacuum is applied. Sponge and vacuum allow removal of infected fluids and promote granulation of the leakage. This results in clean wound grounds and finally allows wound closure. Meanwhile the method was also successfully used in the treatment of necrotic pancreatitis.
C1 [Wedemeyer, J.] Klinikum Reg Hannover GmbH, Klinikum Robert Koch Gehrden, Schwerpunkt Gastroenterol & Hepatol, Med Klin 1, D-30989 Gehrden, Germany.
   [Lankisch, T.] Hannover Med Sch, Klin Gastroenterol Hepatol & Endokrinol, Hannover, Germany.
C3 Hannover Medical School
RP Wedemeyer, J (通讯作者)，Klinikum Reg Hannover GmbH, Klinikum Robert Koch Gehrden, Schwerpunkt Gastroenterol & Hepatol, Med Klin 1, Von Reden Str 1, D-30989 Gehrden, Germany.
EM jochen.wedemeyer@krh.eu
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NR 25
TC 1
Z9 1
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0020-9554
EI 1432-1289
J9 INTERNIST
JI Internist
PD MAR
PY 2013
VL 54
IS 3
BP 309
EP 313
DI 10.1007/s00108-012-3182-7
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 098TT
UT WOS:000315572700005
PM 23430199
DA 2026-07-24
ER
PT J
AU Pliakos, I
   Papavramidis, TS
   Michalopoulos, N
   Deligiannidis, N
   Kesisoglou, I
   Sapalidis, K
   Papavramidis, S
AF Pliakos, Ioannis
   Papavramidis, Theodossis S.
   Michalopoulos, Nick
   Deligiannidis, Nickolaos
   Kesisoglou, Isaak
   Sapalidis, Konstantinos
   Papavramidis, Spiros
TI The Value of Vacuum-Assisted Closure in Septic Patients Treated with
   Laparostomy
SO AMERICAN SURGEON
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; WOUND CLOSURE; TEMPORARY CLOSURE;
   FASCIAL CLOSURE; SILO CLOSURE; WALL; MESH; EXPERIENCE; MANAGEMENT;
   SANDWICH
AB The ideal method of temporary abdominal closure (TAC) should allow rapid closure, easy maintenance, and wound repair with minimal tissue damage. The aim of this retrospective study is to compare open abdomen outcomes between patients managed with vacuum-assisted closure (VAC), and patients managed with other methods of TAC, when septic abdomen is present. Two groups of patients with septic open abdomen: 27 treated with VAC versus 31 treated with other techniques of TAC. We studied open abdomen duration, number of dressing changes, re-exploration rate, successful abdominal closure rate, overall mortality, and development of enteroatmospheric fistulas. The VAC device demonstrated its superiority concerning open abdomen duration (P < 0.001), number of dressing changes (P < 0.001), re-exploration rate (P < 0.002), successful abdominal closure rate (P < 0.0001), and development of enteroatmospheric fistulas (P < 0.00001). Compared with other methods of TAC, our experience with the VAC device demonstrated its advantages concerning clinical feasibility. The high rates of direct fascia closure with an acceptable rate of ventral hernias are further benefits of this technique.
C1 [Pliakos, Ioannis; Papavramidis, Theodossis S.; Michalopoulos, Nick; Deligiannidis, Nickolaos; Kesisoglou, Isaak; Sapalidis, Konstantinos; Papavramidis, Spiros] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Surg 3, GR-54006 Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital
RP Papavramidis, TS (通讯作者)，Aigaiou 6, Thessaloniki 54655, Greece.
EM papavramidis@hotmail.com
RI Sapalidis, Konstantinos/AAV-2866-2021; Michalopoulos,
   Nickos/I-6159-2013; Papavramidis, Theodossis/E-8260-2011; Papavramidis,
   Theodossis/E-8260-2011
OI Michalopoulos, Nickos/0000-0002-7740-4922; Papavramidis,
   Theodossis/0000-0002-7097-9889; Papavramidis,
   Theodossis/0000-0002-7097-9889
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NR 29
TC 30
Z9 33
U1 0
U2 8
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD SEP
PY 2012
VL 78
IS 9
BP 957
EP 961
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 101AL
UT WOS:000315747300010
PM 22964204
DA 2026-07-24
ER
PT J
AU Strub, GM
   Moe, KS
AF Strub, Graham Michael
   Moe, Kristen S.
TI The Use of Negative-Pressure Therapy in the Closure of Complex Head and
   Neck Wounds
SO FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA
LA English
DT Article
DE Negative pressure wound therapy; Vacuum-assisted closure; Complex head
   and neck wounds
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; MANAGEMENT;
   RECONSTRUCTION; EXPERIENCE; FOREHEAD; SUCTION; SKIN
AB The evolution of wound care has seen much technological advancement over many decades. Most recently, negative-pressure therapy, by which a vacuum pressure is applied through a wound bed, has dramatically improved the surgical outcomes of complex wounds. Although initial studies focused on wounds to the abdomen, torso, and extremities, more publications are appearing that demonstrate the efficacy of negative-pressure wound therapy in the head and neck. This article reviews the history and evolution of negative-pressure therapy, highlights the current opinions on its mechanism of action, and summarizes its use in complex head and neck wounds.
C1 [Strub, Graham Michael; Moe, Kristen S.] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle
RP Strub, GM (通讯作者)，Univ Washington, Box 3566515,1959 Northeast Pacific St, Seattle, WA 98195 USA.
EM strub@uw.edu
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NR 46
TC 8
Z9 10
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1064-7406
J9 FACIAL PLAST SURG CL
JI Facial Plast. Surg. Clin. N. Am.
PD FEB
PY 2013
VL 21
IS 1
BP 137
EP +
DI 10.1016/j.fsc.2012.11.005
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 101BQ
UT WOS:000315750600014
PM 23369596
DA 2026-07-24
ER
PT J
AU Bradley, BH
   Cunningham, M
AF Bradley, Beth Hawkins
   Cunningham, Muriel
TI Biofilms in Chronic Wounds and the Potential Role of Negative Pressure
   Wound Therapy
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE biofilms; chronic wounds; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; BACTERIAL BIOFILMS; IN-VITRO; IRRIGATION
   TREATMENT; CLINICAL-EXPERIENCE; CYSTIC-FIBROSIS; LEG ULCERS; INFECTIONS;
   COLONIZATION; SUSCEPTIBILITY
AB Biofilms are communities of microbes that exist in a variety of environments. The extracellular substances secreted by biofilms make them difficult to eradicate, giving the bacterial community in the biofilm a resistance advantage over freefloating (planktonic) microbes. Biofilms are particularly problematic in chronic wounds because of their resistance to conventional therapies and tendency to delay healing. Multimodal strategies to combat wound biofilms are necessary, including wound debridement, antimicrobial treatment, and continued disruption of biofilms. Negative pressure wound therapy with irrigation or instillation may lower the bacterial burden in chronic wounds and prevent the biofilm formation. This article provides an overview of biofilms and evolving strategies to counteract them.
C1 [Bradley, Beth Hawkins] Innovat Therapies Inc, Clin Educ, Gaithersburg, MD 20877 USA.
   [Cunningham, Muriel] Innovat Therapies Inc, Gaithersburg, MD 20877 USA.
RP Bradley, BH (通讯作者)，Innovat Therapies Inc, Clin Educ, 12 Meem Ave, Gaithersburg, MD 20877 USA.
EM bbradley@itimedical.com
OI Cunningham, Muriel/0009-0003-1829-5003
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NR 78
TC 23
Z9 28
U1 0
U2 32
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAR-APR
PY 2013
VL 40
IS 2
BP 143
EP 149
DI 10.1097/WON.0b013e31827e8481
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 103XI
UT WOS:000315952400005
PM 23354367
DA 2026-07-24
ER
PT J
AU Campisi, CC
   Boccardo, F
   Piazza, C
   Campisi, C
AF Campisi, Corrado C.
   Boccardo, Francesco
   Piazza, Cesare
   Campisi, Corradino
TI Evolution of chylous fistula management after neck dissection
SO CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
LA English
DT Review
DE chyle leak; conservative management; lymphatic fistula; surgical
   options; thoracic duct
ID THORACIC-DUCT EMBOLIZATION; VACUUM-ASSISTED CLOSURE; PAPILLARY
   THYROID-CARCINOMA; PRESSURE WOUND THERAPY; POSTOPERATIVE COMPLICATIONS;
   PERCUTANEOUS EMBOLIZATION; CHYLOTHORAX; SOMATOSTATIN; LYMPHEDEMA;
   EXPERIENCE
AB Purpose of review
   The present review is focused on the management of lymphatic, chylous, and thoracic duct lesions following head and neck surgery, with particular attention to these complications after neck dissection. Postoperative scenarios may include chylous fistula, chylothorax, chylomediastinum, chylopericardium, lymphocele, persistent lymphorrhea, and secondary lymphedema.
   Recent findings
   There is a paucity of literature on the treatment of lymphatic, chylous, and thoracic duct injuries following head and neck surgery; however, this review suggests that the most appropriate treatment should include both conservative and surgical approaches. Nonsurgical options consist of low-fat diet with medium-chain triglycerides, total parenteral nutrition, careful monitoring of fluid and electrolytes, drainage of the leakage, somatostatin analogs such as octreotide, and negative-pressure wound therapy. On the other hand, surgical management includes therapeutic percutaneous lymphography-guided thoracic duct cannulation and embolization, thoracic duct ligation, excision and imbrication of leaking lymphatics, chylous fistula surgical/microsurgical repair, fistula closure by locoregional flaps, video-assisted thoracoscopic surgery, thoracotomy, pleurodesis and decortication, pericardial 'window', and pleura-venous/pleura-peritoneal shunts. In addition, single or, preferably, multiple lymphovenous anastomoses may be taken into account.
   Summary
   The various possible clinical presentations of such challenging lymphatic, chylous, and thoracic duct injuries require an appropriate multidisciplinary approach by experienced teams. Primary prevention of these complications can be achieved through adequate surgical planning to minimize lesions, including structured and thorough patient assessment, and centralization of resources and teams.
C1 [Campisi, Corrado C.] Univ Hosp San Martino, IRCCS, IST Natl Inst Canc Res, Dept Surg,Unit Plast & Reconstruct Surg, I-16132 Genoa, Italy.
   [Boccardo, Francesco; Campisi, Corradino] Univ Hosp San Martino, IRCCS, IST Natl Inst Canc Res, Dept Surg,Unit Lymphat Surg, I-16132 Genoa, Italy.
   [Piazza, Cesare] Univ Brescia, Dept Otorhinolaryngol Head & Neck Surg, Brescia, Italy.
C3 University of Genoa; IRCCS AOU San Martino IST; University of Genoa;
   IRCCS AOU San Martino IST; University of Brescia
RP Campisi, CC (通讯作者)，Univ Hosp San Martino, IRCCS, IST Natl Inst Canc Res, Dept Surg,Unit Plast & Reconstruct Surg, Largo Rosanna Benzi 10, I-16132 Genoa, Italy.
EM corrado.campisi@edu.unige.it
RI ; PIAZZA, Cesare/H-5925-2018; BOCCARDO, FRANCESCO MARIA/AAB-7086-2019
OI Campisi, Corrado/0000-0002-3565-8764; PIAZZA,
   Cesare/0000-0002-2391-9357; BOCCARDO, FRANCESCO
   MARIA/0000-0002-5369-6852; Campisi, Corrado/0000-0002-3565-8764
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NR 69
TC 71
Z9 95
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1068-9508
EI 1531-6998
J9 CURR OPIN OTOLARYNGO
JI Curr. Opin. Otolaryngol. Head Neck Surg.
PD APR
PY 2013
VL 21
IS 2
BP 150
EP 156
DI 10.1097/MOO.0b013e32835e9d97
PG 7
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 105ZT
UT WOS:000316111900009
PM 23449286
DA 2026-07-24
ER
PT J
AU Endo, J
   Kuniyoshi, K
   Mochizuki, M
   Shimoyama, K
   Koyama, T
   Aiba, A
   Kadota, R
   Sasaki, Y
AF Endo, Jun
   Kuniyoshi, Kazuki
   Mochizuki, Makondo
   Shimoyama, Katsuhito
   Koyama, Tadaaki
   Aiba, Atsuomi
   Kadota, Ryo
   Sasaki, Yasuhito
TI Two-staged hindfoot reconstruction with vascularized fibula graft for
   calcaneal osteomyelitis caused by methicillin-resistant Staphylococcus
   aureus: A case report
SO MICROSURGERY
LA English
DT Article
ID FRACTURES
AB Hindfoot reconstruction after calcaneal osteomyelitis is a challenging procedure designed to restore the weight bearing function of the heel and to allow a functional reconstruction of the Achilles tendon. Some patients require subtalar arthrodesis after primary calcaneal osteosyntesis or hindfoot reconstruction due to the considerable pain associated with weight-bearing caused by the irregular surface of the subtalar joint. To date, no reports have shown a case of hindfoot reconstruction with subtalar arthrodesis using a pedicled vascularized fibula graft. We report a case of a 24-year-old woman who presented with calcaneal methicillin-resistant Staphylococcus aureus osteomyelitis after open comminuted fracture due to a fall. Radical debridement of bone and soft tissue was repeated six times in combination with negative pressure wound therapy, followed by hindfoot reconstruction with pedicled vascularized fibula and subtalar arthrodesis. Good functional restoration had been achieved by the final follow-up 18 months after surgery. (c) 2013 Wiley Periodicals, Inc. Microsurgery, 2013.
C1 [Endo, Jun; Kuniyoshi, Kazuki; Mochizuki, Makondo; Shimoyama, Katsuhito; Koyama, Tadaaki; Aiba, Atsuomi; Kadota, Ryo; Sasaki, Yasuhito] Numazu City Hosp, Dept Orthopaed Surg, Shizuoka 4100302, Japan.
RP Endo, J (通讯作者)，Numazu City Hosp, 550 Higashi Shiiji, Shizuoka 4100302, Japan.
EM orthopaedics@hotmail.co.jp
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NR 17
TC 10
Z9 16
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
J9 MICROSURG
JI Microsurgery
PD MAR
PY 2013
VL 33
IS 3
BP 232
EP 235
DI 10.1002/micr.22070
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 108ZR
UT WOS:000316335400011
PM 23345037
DA 2026-07-24
ER
PT J
AU Mhatre, P
   Huang, M
   Cohler, M
AF Mhatre, Priya
   Huang, Mark
   Cohler, Marissa
TI Autonomic Dysreflexia With Negative-Pressure Wound Therapy: A Report of
   Two Cases
SO PM&R
LA English
DT Article
ID SPINAL-CORD-INJURY; ULCER RISK-FACTORS; TOXICITY; LIDOCAINE
AB Pressure ulcers and autonomic dysreflexia (AD) are common complications that may affect individuals with spinal cord injury (SCI). Negative-pressure wound therapy (NPWT) is a frequently used modality to aid in wound healing in the treatment of pressures ulcers in patients with SCI. Although the common triggers of AD have been well described in the literature, there have been no formal reports of NPWT itself as a cause of AD. We detail 2 cases of patients with SCI and with AD thought to be secondary to NPWT and discuss modifications made to allow for continued treatment with NPWT while minimizing further episodes of AD. We propose that NPWT should be considered as a potential source of AD in patients with SCI undergoing this therapy. PM R2013;5:238-241
C1 [Mhatre, Priya; Huang, Mark; Cohler, Marissa] Northwestern Univ, Feinberg Sch Med, Rehabil Inst Chicago, Dept Phys Med & Rehabil, Chicago, IL 60611 USA.
C3 Shirley Ryan AbilityLab; Northwestern University; Feinberg School of
   Medicine
RP Huang, M (通讯作者)，Northwestern Univ, Feinberg Sch Med, Rehabil Inst Chicago, Dept Phys Med & Rehabil, 345 E Super St, Chicago, IL 60611 USA.
EM mhuang@ric.org
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NR 15
TC 0
Z9 0
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1934-1482
J9 PM&R
JI PM&R
PD MAR
PY 2013
VL 5
IS 3
BP 238
EP 241
DI 10.1016/j.pmrj.2012.11.008
PG 4
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation; Sport Sciences
GA 110HN
UT WOS:000316433300015
PM 23481332
DA 2026-07-24
ER
PT J
AU Fitzgerald, JEF
   Gupta, S
   Masterson, S
   Sigurdsson, HH
AF Fitzgerald, James E. F.
   Gupta, Shradha
   Masterson, Sarah
   Sigurdsson, Helgi H.
TI Laparostomy management using the ABThera™ open abdomen negative pressure
   therapy system in a grade IV open abdomen secondary to acute
   pancreatitis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Acute pancreatitis; Laparostomy; Negative pressure therapy; Open
   abdomen; Vacuum dressing
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; RANDOMIZED
   CONTROLLED-TRIAL; INTRAABDOMINAL HYPERTENSION; INTERNATIONAL-CONFERENCE;
   SUBATMOSPHERIC PRESSURE; DIFFUSE PERITONITIS; FASCIAL CLOSURE; WOUNDS;
   ETAPPENLAVAGE
AB Wound control in laparostomy for the treatment of intra-abdominal hypertension remains challenging and numerous techniques have been described. We report the first UK experience with a new commercially available device specifically designed to facilitate management of the open abdomen. A 44-year-old gentleman presented with a 3-day history of constant severe epigastric pain and associated vomiting. Amylase was markedly elevated and he was admitted for supportive management of pancreatitis, with subsequent transfer to intensive care due to severe systemic inflammatory syndrome. The patient decompensated, developing intra-abdominal hypertension with renal and respiratory failure. This was successfully managed by performing a laparostomy and using an ABThera Open Abdomen Negative Pressure Therapy System (KCI, San Antonio, TX). We describe its use to facilitate wound control, including enteroatmospheric fistula, allowing granulation and eventual restoration of gastrointestinal continuity 383-days after admission. We found the ABThera System proved to be a useful treatment adjunct, protecting intra-abdominal contents while removing large volumes of exudate and infected material from within the abdominal cavity. Complex cases such as this remain infrequent and this article provides a summary of our experience, including a review of indications for laparostomy and the underlying basic science in this difficult area.
C1 [Fitzgerald, James E. F.; Gupta, Shradha; Sigurdsson, Helgi H.] Chelsea & Westminster NHS Hosp Trust, Dept Gen Surg, London SW10 9NH, England.
   [Masterson, Sarah] Chelsea & Westminster NHS Hosp Trust, Tissue Viabil Serv, London SW10 9NH, England.
RP Fitzgerald, JEF (通讯作者)，Chelsea & Westminster NHS Hosp Trust, Dept Gen Surg, 369 Fulham Rd, London SW10 9NH, England.
EM edwardfitzgerald@doctors.org.uk
RI Fitzgerald, James/F-2565-2013
OI Fitzgerald, James/0000-0002-4453-5117
FU Kinetic Concepts Inc.
FX Figure 1 ABThera (TM) Open Abdomen Negative Pressure Therapy System,
   Courtesy of KCI Licensing, Inc. J. E. F. F. has received speaker fees
   for the presentation of this case since the manuscript was prepared from
   Kinetic Concepts Inc.
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NR 36
TC 16
Z9 23
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2013
VL 10
IS 2
BP 138
EP 144
DI 10.1111/j.1742-481X.2012.00953.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 112DB
UT WOS:000316571100005
PM 22487377
OA Green Submitted
DA 2026-07-24
ER
PT J
AU van den Bulck, R
   Siebers, Y
   Zimmer, R
   Acton, C
   Janzing, H
   Lang, W
AF van den Bulck, Rosine
   Siebers, Yvonne
   Zimmer, Robert
   Acton, Claire
   Janzing, Heinrich
   Lang, Werner
TI Initial clinical experiences with a new, portable, single-use negative
   pressure wound therapy device
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Dynamic pressure control; DPC; NPWT; NPWT; ROCF; VAC therapy; VAC Via
ID VACUUM-ASSISTED CLOSURE
AB Since the introduction of negative pressure wound therapy in combination with reticulated open cell foam (NPWT/ROCF) in 1997, the clinical and economic benefits of this therapy have been showed in several randomised-controlled studies. This article describes the clinical application of a new portable NPWT unit. The V.A.C.Via Therapy System (KCI USA, Inc., San Antonio, TX) offers continuous negative pressure and dynamic pressure control for wound treatment of low exudating (<80 ml/day), small-to-medium size wounds, grafts and flaps in all care settings, including homecare. We describe four cases in which this new device was successfully used.
C1 [van den Bulck, Rosine] Hosp Edith Cavell, Dept Wound & Stoma Care, B-1000 Brussels, Belgium.
   [Siebers, Yvonne] VieCuri Med Ctr, Dept Surg Wound Care, Venlo, Netherlands.
   [Zimmer, Robert] Univ Hosp, Dept Surg Wound Care, Erlangen, Germany.
   [Acton, Claire] Guys & St Thomas NHS Fdn Trust, Dept Surg Tissue Viabil, London, England.
   [Janzing, Heinrich] VieCuri Med Ctr, Dept Surg, Venlo, Netherlands.
   [Lang, Werner] Univ Hosp, Dept Vasc Surg, Erlangen, Germany.
C3 VieCuri Medical Center; University of Erlangen Nuremberg; Guy's & St
   Thomas' NHS Foundation Trust; VieCuri Medical Center; University of
   Erlangen Nuremberg
RP van den Bulck, R (通讯作者)，Hosp Edith Cavell, Dept Wound & Stoma Care, B-1000 Brussels, Belgium.
EM rosine.vandenbulck@gmail.com
CR Argenta A, 2003, EUR TISS REP SOC FOC
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   FDA, FDA CLEAR LETT VAC V
   Gabriel A, 2011, WOUNDS, V23, pA22
   McNulty A., 2009, CLIN S ADV SKIN WOUN
   McNulty A, 2011, S ADV WOUND CAR APR
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
NR 12
TC 10
Z9 10
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2013
VL 10
IS 2
BP 145
EP 151
DI 10.1111/j.1742-481X.2012.00954.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 112DB
UT WOS:000316571100006
PM 22432923
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Tuncel, U
   Erkorkmaz, Ü
   Turan, A
AF Tuncel, Umut
   Erkorkmaz, Unal
   Turan, Aydin
TI Clinical evaluation of gauze-based negative pressure wound therapy in
   challenging wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Challenging wounds; Gauze; Negative pressure; Wound care; Wound filler
ID VACUUM-ASSISTED CLOSURE; DOUBLE-BLIND; EXPERIENCE; TRANSDUCTION;
   POLYHEXANIDE; ULCERS; IMPACT; FLAPS; FOAM
AB The aim of this randomised clinical study was to evaluate the effectiveness and safety of gauze-based negative pressure wound therapy (NPWT) in patients with challenging wounds. A total of 50 consecutive patients who had wound drainage for more than 5 days, required open wound management and had existence of culture positive infection were included the study. In this study, gauze-based NPWT was compared with conventional dressing therapy in the treatment of patients with difficult-to-heal wounds. The patients were randomly divided into two groups. Group I (n = 25) was followed by conventional antiseptic (polyhexanide solution) dressings, and group II (n = 25) was treated with saline-soaked antibacterial gauze-based NPWT. The wounds' sizes, number of debridement, bacteriology and recurrence were compared between group I and group II. The mean age of the patients was 59 center dot 50 years (range 2397). In group I, average wound sizes of pre- and post-treatment periods were 50 center dot 60 +/- 55 center dot 35 and 42 center dot 50 +/- 47 center dot 92 cm2, respectively (P < 0 center dot 001). Average duration of treatment was 25 center dot 52 +/- 16 center dot 99 days, and average wound size reduction following the treatment was 19 center dot 99% in this group. In group II, the wounds displayed considerable shrinkage, accelerated granulation tissue formation, decreased and cleared away exudate. The average wound sizes in the pre- and post-treatment periods were 98 center dot 44 +/- 100 center dot 88 and 72 center dot 08 +/- 75 center dot 78 cm2, respectively (P < 0 center dot 001). Average duration of treatment was 11 center dot 96 +/- 2 center dot 48 days, and average wound size reduction following the treatment was 32 center dot 34%. The patients treated with antibacterial gauze-based NPWT had a significantly reduced recurrence (2 wounds versus 14 wounds, P = 0 center dot 001), and increased number of the culture-negative cases (22 wounds versus 16 wounds, P < 0 center dot 047) in a follow-up period of 12 months. There was a statistically significant difference between two groups in all measurements. As a result, we can say that the gauze-based NPWT is a safe and effective method in the treatment of challenging infective wounds when compared with conventional wound management.
C1 [Tuncel, Umut; Turan, Aydin] Gaziosmanpasa Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, TR-60150 Tokat, Turkey.
   [Erkorkmaz, Unal] Gaziosmanpasa Univ, Fac Med, Dept Biostat, TR-60150 Tokat, Turkey.
C3 Tokat Gaziosmanpasa University; Tokat Gaziosmanpasa University
RP Tuncel, U (通讯作者)，Gaziosmanpasa Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, TR-60150 Tokat, Turkey.
EM drumuttuncel@gmail.com
RI Tuncel, Umut/P-3185-2015; Erkorkmaz, Ünal/AAA-4241-2022; Turan,
   Aydın/V-6669-2017
OI Tuncel, Umut/0000-0001-5029-2927; Erkorkmaz, Ünal/0000-0002-8497-4704;
   Turan, Aydın/0000-0002-1540-1443
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   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
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   Tavakoli K, 1999, BRIT J PLAST SURG, V52, P476, DOI 10.1054/bjps.1999.3126
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NR 30
TC 20
Z9 21
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2013
VL 10
IS 2
BP 152
EP 158
DI 10.1111/j.1742-481X.2012.00955.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 112DB
UT WOS:000316571100007
PM 22420837
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Rycerz, AM
   Slack, P
   McNulty, AK
AF Rycerz, Anthony M.
   Slack, Paul
   McNulty, Amy K.
TI Distribution assessment comparing continuous and periodic wound
   instillation in conjunction with negative pressure wound therapy using
   an agar-based model
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Instillation therapy; Negative pressure wound therapy; V; A; C; Wound
   healing
AB Negative pressure wound therapy (NPWT) is a widely accepted and effective treatment for various wound types, including complex wounds. Negative pressure with instillation was initially used as a gravity-fed system whereby reticulated, open-cell foam in the wound bed was periodically exposed to cycles of soaking with instillation solution followed by NPWT. Recent publications have alluded to positive outcomes with continuous instillation, where fluid is delivered simultaneously with negative pressure. To evaluate the distribution of instillation solutions to wound beds in conjunction with negative pressure, agar-based models were developed and exposed to coloured instillation solutions to identify exposure intensity via agar staining. This model allowed comparison of continuous- versus periodic-instillation therapy with negative pressure. Continuous instillation at a rate of 30 cc/hour with negative pressure showed isolated exposure of instillation fluid to wound beds in agar wound models with and without undermining and tunnelling. In contrast, periodic instillation illustrated uniform exposure of the additive to the entire wound bed including undermined and tunnel areas, with increased staining with each instillation cycle. These findings suggest that periodic instillation facilitates more uniform exposure throughout the wound, including tunnels and undermining, to instillation solutions, thereby providing therapy consistent with the clinician-ordered treatment.
C1 [Rycerz, Anthony M.] Kinet Concepts Inc, AHS Appl Sci, San Antonio, TX 78249 USA.
RP Rycerz, AM (通讯作者)，Kinet Concepts Inc, AHS Appl Sci, 6203 Farinon Dr,Bldg 5, San Antonio, TX 78249 USA.
EM anthony.rycerz@kci1.com
CR Brown P., 2009, QUICK REFERENCE WOUN
   Chatterjee Justin S, 2005, Int Wound J, V2, P258
   Fleischmann W, 2009, INFECTION, V37, P4
   Gabriel A., 2011, MEDSCAPE REFERE 0519
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NR 13
TC 21
Z9 24
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2013
VL 10
IS 2
BP 214
EP 220
DI 10.1111/j.1742-481X.2012.00968.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 112DB
UT WOS:000316571100016
PM 22487428
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Norris, R
   Chapman, AWP
   Krikler, S
   Krkovic, M
AF Norris, R.
   Chapman, A. W. P.
   Krikler, S.
   Krkovic, M.
TI A novel technique for the treatment of infected metalwork in orthopaedic
   patients using skin closure over irrigated negative pressure wound
   therapy dressings
SO ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
LA English
DT Article
DE Vacuum-assisted closure; Negative pressure wound therapy; Infected
   orthopaedic metalwork
ID VACUUM-ASSISTED CLOSURE; INSTRUMENTED SPINAL-FUSION; IMPLANT INFECTIONS;
   DEEP INFECTIONS; CHILDREN
AB INTRODUCTION There has been recent interest in the use of negative pressure wound therapy (NWPT) as an adjunct to parenteral antibiotics in the treatment of infection in orthopaedic patients with metalwork in situ. To address some of the limitations of standard NPWT in this situation, the senior author has developed a modified method of treatment for infected metalwork (excluding arthroplasty) in orthopaedic patients that includes irrigation and skin closure over the standard NPWT dressing.
   METHODS This retrospective study examined the outcome of a case series of 16 trauma and orthopaedic patients with deep infection involving metalwork in whom this modified form of NPWT was used. In conjunction with standard parenteral antibiotic therapy and a multidisciplinary approach, this modified technique included serial debridements in theatre, irrigation and negative pressure dressings over a white polyvinyl alcohol foam (KCI, Kidlington, UK) as well as closure of the skin over the foam.
   RESULTS Among the 16 patients, there was a variety of upper and lower limb as well as spinal trauma and elective cases. In all 16 patients, there was successful resolution of the infection with no early or unplanned removal of any metalwork required.
   CONCLUSIONS Patients with infected metalwork are a heterogeneous group, and often suffer high morbidity and mortality. The modified NPWT technique shows potential as an adjunct in the treatment of complex orthopaedic patients with infected metalwork.
C1 [Norris, R.; Chapman, A. W. P.; Krikler, S.; Krkovic, M.] Univ Hosp Coventry & Warwickshire NHS Trust, Coventry, W Midlands, England.
C3 University of Warwick
RP Norris, R (通讯作者)，22 Peacocks, Warwick CV34 6BS, England.
EM rory_norris@yahoo.co.uk
OI Krkovic, Matija/0000-0003-2172-2849
CR [Anonymous], SCI WOUND THER
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   van Rhee MA, 2007, SPINE J, V7, P596, DOI 10.1016/j.spinee.2006.09.002
   Vicario C, 2007, ACTA ORTHOP BELG, V73, P102
NR 15
TC 10
Z9 15
U1 0
U2 7
PU ROYAL COLL SURGEONS ENGLAND
PI LONDON
PA 35-43 LINCOLN'S INN FIELDS, LONDON WC2A 3PN, ENGLAND
SN 0035-8843
J9 ANN ROY COLL SURG
JI Ann. R. Coll. Surg. Engl.
PD MAR
PY 2013
VL 95
IS 2
BP 118
EP 124
DI 10.1308/003588413X13511609957254
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 112LL
UT WOS:000316593600010
PM 23484994
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Karl, T
   Woeste, S
AF Karl, T.
   Woeste, S.
TI Prevention of inguinal wound healing disorders in vascular surgery.
   Results of using an epidermal negative pressure system (Prevena™)
SO GEFASSCHIRURGIE
LA German
DT Article
DE Wound healing disorders in the groin; Prevention; Negative pressure
   wound therapy (NPWT); Graft infection; Cost-benefit analysis
AB Complications of wound healing and wound infections (surgical site infections) are a serious problem after surgery. Consequences for patients include a reduction in quality of life, a threat to the therapy outcome, an increased length of stay in hospital and increased mortality. For the hospital substantial additional costs of up to 80,000 US$ have been reported, which are not adequately funded by the German diagnosis-related groups (G-DRG) system. Based on the worldwide positive experience of negative pressure wound therapy (NPWT) a new device is now available to reduce the incidence of wound healing complications after surgery by prophylactic use of an epidermal NPWT system (Prevena (TM) Incision Management System, Kinetic Concepts, San Antonio, Tx). In our case study (n = 14), the effectiveness and the economic benefits of the Prevena (TM) system after inguinal vascular access compared to a historical collective group were analyzed. The system was used only in patients with a risk score a parts per thousand yenaEuro parts per thousand 4 points. In the Prevena (TM) group there were no wound healing disorders and in the control group one patient (7.14%) developed a wound infection. From an economic point of view, the increased costs by the prophylactic use of the Prevena (TM) system are justified by surgery with a high incidence of wound healing disorders and infections and at the same time high resulting costs in high-risk patients.
C1 [Karl, T.; Woeste, S.] Klin Rotes Kreuz, Abt Gefass & Endovasc Chirurg, D-60316 Frankfurt, Germany.
RP Karl, T (通讯作者)，Klin Rotes Kreuz, Abt Gefass & Endovasc Chirurg, Konigswarterstr 16, D-60316 Frankfurt, Germany.
EM dr.t.karl@web.de
CR [Anonymous], SURG SIT INF PREV TR
   Bandyk DF, 2000, VASCULAR SURG, P733
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   Exton RJ, 2007, EUR J VASC ENDOVASC, V34, P188, DOI 10.1016/j.ejvs.2007.03.012
   Kipaldi DV, 2011, WOUND REPAIR REGEN, V19, P588
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   Zeeuw J, 2007, MED KLIN, V102, P858
   Zegelman M, 2008, LEITLINIEN GEFASSINF
NR 8
TC 7
Z9 7
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0948-7034
J9 GEFASSCHIRURGIE
JI Gefasschirurgie
PD MAR
PY 2013
VL 18
IS 2
BP 120
EP 125
DI 10.1007/s00772-012-1046-z
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 113BG
UT WOS:000316640200011
DA 2026-07-24
ER
PT J
AU Soares, MO
   Dumville, JC
   Ashby, RL
   Iglesias, CP
   Bojke, L
   Adderley, U
   McGinnis, E
   Stubbs, N
   Torgerson, DJ
   Claxton, K
   Cullum, N
AF Soares, Marta O.
   Dumville, Jo C.
   Ashby, Rebecca L.
   Iglesias, Cynthia P.
   Bojke, Laura
   Adderley, Una
   McGinnis, Elizabeth
   Stubbs, Nikki
   Torgerson, David J.
   Claxton, Karl
   Cullum, Nicky
TI Methods to Assess Cost-Effectiveness and Value of Further Research When
   Data Are Sparse: Negative-Pressure Wound Therapy for Severe Pressure
   Ulcers
SO MEDICAL DECISION MAKING
LA English
DT Article
DE Markov model; elicited evidence; pilot trial; negative pressure wound
   therapy; sparse; evidence synthesis; expected value of information;
   research design; cost-effectiveness analysis
ID RANDOMIZED CONTROLLED-TRIAL; VENOUS LEG ULCERS; EXPECTED VALUE;
   PROBABILITY-DISTRIBUTIONS; INFORMATION ANALYSIS; DECISION-MAKING;
   MULTICENTER; EFFICACY; MODEL; CARE
AB Health care resources are scarce, and decisions have to be made about how to allocate funds. Often, these decisions are based on sparse or imperfect evidence. One such example is negative-pressure wound therapy (NPWT), which is a widely used treatment for severe pressure ulcers; however, there is currently no robust evidence that it is effective or cost-effective. This work considers the decision to adopt NPWT given a range of alternative treatments, using a decision analytic modeling approach. Literature searches were conducted to identify existing evidence on model parameters. Given the limited evidence base, a second source of evidence, beliefs elicited from experts, was used. Judgments from experts on relevant (uncertain) quantities were obtained through a formal elicitation exercise. Additionally, data derived from a pilot trial were also used to inform the model. The 3 sources of evidence were collated, and the impact of each on cost-effectiveness was evaluated. An analysis of the value of further information indicated that a randomized controlled trial may be worthwhile in reducing decision uncertainty, where from a set of alternative designs, a 3-arm trial with longer follow-up was estimated to be the most efficient. The analyses presented demonstrate how allocation decisions about medical technologies can be explicitly informed when data are sparse and how this kind of analyses can be used to guide future research prioritization, not only indicating whether further research is worthwhile but what type of research is needed and how it should be designed.
C1 [Soares, Marta O.; Bojke, Laura; Claxton, Karl] Univ York, Ctr Hlth Econ, York YO10 5DD, N Yorkshire, England.
   [Dumville, Jo C.; Ashby, Rebecca L.; Iglesias, Cynthia P.; Torgerson, David J.] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England.
   [Adderley, Una] Univ Teesside, Sch Hlth & Social Care, Middlesbrough, Cleveland, England.
   [McGinnis, Elizabeth] Leeds Gen Infirm, Leeds Teaching Hosp Natl Hlth Serv NHS Trust, Leeds, W Yorkshire, England.
   [Stubbs, Nikki] St Marys Hosp, NHS Leeds Community Healthcare, Leeds, W Yorkshire, England.
   [Cullum, Nicky] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester, Lancs, England.
C3 University of York - UK; University of York - UK; University of
   Teesside; Leeds General Infirmary; University of Leeds; University of
   Manchester
RP Soares, MO (通讯作者)，Univ York, Ctr Hlth Econ, Alcuin A Block, York YO10 5DD, N Yorkshire, England.
EM marta.soares@york.ac.uk
RI Cullum, Nicky/F-2438-2011; McGinnis, Elizabeth/PNF-2864-2026; Torgerson,
   David/L-4566-2019; Soares, Marta Ferreira Oliveira/HJH-3434-2023;
   Dumville, Jo/O-7867-2014
OI Cullum, Nicky/0000-0003-2631-123X; Torgerson, David/0000-0002-1667-4275;
   Soares, Marta Ferreira Oliveira/0000-0003-1579-8513; Adderley,
   Una/0000-0003-1894-3755; Dumville, Jo/0000-0002-6546-3685; McGinnis,
   Elizabeth/0000-0002-2848-9149
FU Medical Research Council [G0501814]; MRC [G0501892, G0501814] Funding
   Source: UKRI; Medical Research Council [G0501814, G0501892] Funding
   Source: researchfish; National Institute for Health Research
   [NF-SI-0512-10028] Funding Source: researchfish
FX Received 10 February 2011 from the Centre for Health Economics, The
   University of York, York, UK (MOS, LB, KC); Department of Health
   Sciences, The University of York, York, UK (JCD, RLA, CI, DT); School of
   Health and Social Care, Teesside University, Middlesbrough, UK (UA);
   Leeds Teaching Hospitals National Health Service (NHS) Trust, Leeds
   General Infirmary, Leeds, UK (EM); NHS Leeds Community Healthcare, St
   Mary's Hospital, Leeds, UK (NS); and School of Nursing, Midwifery and
   Social Work, University of Manchester, Manchester, UK (NC). This work
   was supported by the Medical Research Council (grant number G0501814).
   Kinetic Concepts Inc. supplied the NPWT machines used in the pilot trial
   at no cost. The manufacturer had no role in the design of the pilot
   trial or in the collection, analysis, and interpretation of the data.
   Revision accepted for publication 24 March 2012.
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NR 52
TC 24
Z9 29
U1 1
U2 21
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0272-989X
EI 1552-681X
J9 MED DECIS MAKING
JI Med. Decis. Mak.
PD APR
PY 2013
VL 33
IS 3
SI SI
BP 415
EP 436
DI 10.1177/0272989X12451058
PG 22
WC Health Care Sciences & Services; Health Policy & Services; Medical
   Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Medical Informatics
GA 113RH
UT WOS:000316685000012
PM 22927694
DA 2026-07-24
ER
PT J
AU Tocco, MP
   Ballardini, M
   Masala, M
   Perozzi, A
AF Tocco, Maria Pia
   Ballardini, Milva
   Masala, Marcello
   Perozzi, Antonio
TI Post-sternotomy chronic osteomyelitis: is sternal resection always
   necessary?
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Post-sternotomy sternocutaneous fistula; Post-sternotomy chronic
   osteomyelitis; Post-sternotomy chronic dehiscence; Chronic sternal wound
   infection
ID POSTOPERATIVE MEDIASTINITIS; ANTIBIOTIC-TREATMENT; WOUND COMPLICATIONS;
   CARDIAC-SURGERY; RISK-FACTORS; MANAGEMENT; MICROBIOLOGY; INFECTIONS
AB The goal of this study was to investigate alternative strategies to the sternal resection in the treatment of post-sternotomy osteomyelitis. We report our experience in the treatment of chronic infection of median sternotomy following open heart surgery without sternal resection.
   A 4-year retrospective study was performed, consisting of 70 patients affected by post-sternotomy sternocutaneous fistulas due to chronic osteomyelitis: 45 patients underwent only medical treatment and 25 underwent steel wire removal and surgical debridement (conservative surgery). Of the 25, 7 patients underwent an additional vacuum assisted closure (VAC) therapy due to widespread infected subcutaneous tissue. The diagnosis of osteomyelitis was supported via 3D CT scan images.
   Complete wound healing was achieved in 67 patients including a patient who achieved healing after being affected by a fistula for over 24 years before coming under our observation, another, affected by mycobacteria other than tuberculosis osteomyelitis, who needed antimicrobial treatment for a period of 30 months and 2 who were affected by Aspergillus infection and needed radical cartilage removal. Fistula relapses were observed in 6 patients of the total 70, possibly due to the too short-term antibiotic therapy used in the presence of coagulase-negative Staphylococcus (CoNS) with multiple resistances and in the presence of Corynebacterium species.
   Post-sternotomy chronic osteomyelitis can be successfully treated mainly by systemic antimicrobial therapy alone, without mandatory surgical treatments, provided that accurate microbiological and radiological studies are performed. The presence of CoNS and Corynebacterium species seemed to be associated with a need for a prolonged combined antimicrobial therapy with a minimum of 6 months up to a maximum of 18 months. The CT scan and the 3D reconstruction of the sternum proved to be a good method to evaluate the status of the sternum and support the treatments. The VAC therapy was not useful in treating osteomyelitis, although, if used appropriately in the postoperative deep sternal wound infection with the sponge fitted between the sternal edges, it seems to be an effective method to eradicate the infection in the sternum and to prevent chronic osteomyelitis.
C1 [Tocco, Maria Pia] San Filippo Neri Hosp, Thorac Surg Unit, Rome, Italy.
   [Ballardini, Milva] San Filippo Neri Hosp, Microbiol Unit, Rome, Italy.
   [Masala, Marcello] San Filippo Neri Hosp, Infect Dis Unit, Rome, Italy.
   [Perozzi, Antonio] San Filippo Neri Hosp, Dept Radiol, Rome, Italy.
C3 San Filippo Neri Hospital; San Filippo Neri Hospital; San Filippo Neri
   Hospital; San Filippo Neri Hospital
RP Tocco, MP (通讯作者)，San Filippo Neri Hosp, Thorac Surg Unit, Via Martinotti 20, Rome, Italy.
EM mptocco@yahoo.it
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NR 14
TC 35
Z9 43
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD APR
PY 2013
VL 43
IS 4
BP 715
EP 721
DI 10.1093/ejcts/ezs449
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 113VB
UT WOS:000316696300017
PM 22869252
OA Bronze
DA 2026-07-24
ER
PT J
AU Wolvos, T
AF Wolvos, Tom
TI The Use of Negative Pressure Wound Therapy with an Automated, Volumetric
   Fluid Administration: An Advancement in Wound Care
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; INSTILLATION; INSTILL(R); MULTICENTER;
   INFECTIONS; DRESSINGS; ULCERS; TRIAL
AB Introduction. This small pilot study introduces initial clinical experience with a system combining negative pressure wound therapy and negative pressure wound therapy with instillation (NPWT/NPWTi, V.A.C. ULTA (TM) Negative Pressure Wound Therapy, KCI USA, Inc, San Antonio, TX). Materials and Methods. The NPWT system with instillation delivers controlled volumetric fluid instillation, and uses instillation-specific reticulated open-cell foam (ROCF) dressings: Dressing A (ROCF-V, V.A.C. VeraFlo (TM) Dressing, KCI USA, Inc, San Antonio, TX) or Dressing B (ROCF-VC, V.A.C. VeraFlo Cleanse (TM) Dressing, KCI USA, Inc, San Antonio, TX). Six patients ranging in age from 26-83 years were treated with either NPWT with instillation and Dressing A or Dressing B, and Microcyn (R) antiseptic solution (Oculus Innovative Sciences, Petaluma, CA) (n = 5) or quarter- strength Dakin's Solution (R) (Century Pharmaceuticals, Indianapolis, IN) (n = 1), as the instillate. Negative pressure wound therapy was applied in 1 patient to a single wound using Dressing C (ROCF; V.A.C.(R) GranuFoam (TM) Dressing, KCI USA, Inc, San Antonio, TX) in one half of the wound, and Dressing B in the other half. In this patient series, instillation was repeated every 2-4 hours with a 5-10 minute soak time followed by negative pressure at -100 mm Hg to -125 mm Hg. All wounds were closed by skin graft or primary, secondary, or delayed primary intention. Results. For the wound treated with NPWT only, no difference in degree or quality of granulation tissue formation was observed by either dressing. Conclusion. The system worked well across multiple wound types in either NPWT mode or NPWT with instillation mode, and no complications were observed. Larger patient studies with controls are needed to validate the clinical observations in this patient series.
C1 Scottsdale Healthcare Osborn Med Ctr, Scottsdale, AZ 85251 USA.
C3 Scottsdale Healthcare Osborn
RP Wolvos, T (通讯作者)，Scottsdale Healthcare Osborn Med Ctr, 7400 E Osborn Rd, Scottsdale, AZ 85251 USA.
EM twolvosmd@scottsdalesurgical.com
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NR 24
TC 19
Z9 23
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2013
VL 25
IS 3
BP 75
EP 83
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 115WJ
UT WOS:000316842300006
PM 25867939
DA 2026-07-24
ER
PT J
AU Ottosen, B
   Pedersen, BD
AF Ottosen, B.
   Pedersen, B. D.
TI Patients' experiences of NPWT in an outpatient setting in Denmark
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE patient experience; negative pressure wound therapy;
   phenomenological-hermeneutic approach
ID VACUUM-ASSISTED CLOSURE; WOUNDS
AB Objective: To study patients' experiences of negative pressure wound therapy (NPWT) used for wounds of various aetiologies in the outpatient setting and the influences on daily life.
   Method: In this qualitative study, a phenomenological-hermeneutic approach was used. Ten patients underwent qualitative interviews regarding their NPWT treatment. The French philosopher, Ricoeur's, theory of interpretation guided the data analysis, which included three levels: naive reading, structural analysis and critical interpretation and discussion.
   Results: The patients experienced a high level of dependency on the equipment and a greater confidence as treatment proceeded. There is a link between treatment and tolerance. Duration of treatment influenced the patients' ability to cope with it and the patients gradually developed an acceptance of the technology. The support of relatives was important, particularly after delivery of a baby and wound treatment following caesarean section. Some patients were embarrassed due to the appearance and smell of the exudate.
   Conclusion: Use of NPWT clearly influences patients' daily life. Patients have a feeling of being dependent on and attached to the equipment, and they experienced embarrassment about odour, anxiety and uneasiness in relation to complications, a need for relatives' support and other social-relation issues. It was important to include relatives as a resource and make use of the opportunity they presented to assist patients during information sessions about treatment.
C1 [Ottosen, B.] Odense Univ Hosp, Dept Plast Surg, Univ Ctr Wound Healing, Odense, Denmark.
   [Pedersen, B. D.] Univ So Denmark, Fac Hlth Sci, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark
RP Ottosen, B (通讯作者)，Odense Univ Hosp, Dept Plast Surg, Univ Ctr Wound Healing, Odense, Denmark.
EM birthe.ottosen@ouh.regionsyddanmark.dk
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   Lindseth A, 2004, SCAND J CARING SCI, V18, P145, DOI 10.1111/j.1471-6712.2004.00258.x
   Moffatt CJ, 2011, J WOUND CARE, V20, P512, DOI 10.12968/jowc.2011.20.11.512
   Morse J., 1993, QUALITATIVE HLTH RES, V3, P267, DOI [DOI 10.1177/104973239300300301, 10.1177/104973239300300301]
   NELSON EA, 2007, EWMA J, V7, P5
   Pedersen BD, 1999, NURSING PRACTICE LAN
   Ricoeur Paul., 1976, INTERPRETATION THEOR
   Runkel N, 2011, INJURY, V42, pS1, DOI 10.1016/S0020-1383(11)00041-6
   Scheel ME, 2008, SCAND J CARING SCI, V22, P629, DOI 10.1111/j.1471-6712.2007.00564.x
   Ubbink DT, 2008, COCHRANE DB SYST REV, V3
NR 14
TC 12
Z9 14
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2013
VL 22
IS 4
BP 197
EP 206
DI 10.12968/jowc.2013.22.4.197
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA 118WW
UT WOS:000317058300006
PM 23702673
DA 2026-07-24
ER
PT J
AU Navsaria, P
   Nicol, A
   Hudson, D
   Cockwill, J
   Smith, J
AF Navsaria, Pradeep
   Nicol, Andrew
   Hudson, Donald
   Cockwill, John
   Smith, Jennifer
TI Negative pressure wound therapy management of the "open abdomen"
   following trauma: a prospective study and systematic review
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Negative Pressure Wound Therapy (NPWT); Grade 1 and 2 open abdomen;
   Abdominal trauma; Fascial closure
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; FASCIAL
   CLOSURE; INTRAABDOMINAL HYPERTENSION; RETROSPECTIVE EVALUATION
AB Introduction: The use of Negative Pressure Wound Therapy (NPWT) for temporary abdominal closure of open abdomen (OA) wounds is widely accepted. Published outcomes vary according to the specific nature and the aetiology that resulted in an OA. The aim of this study was to evaluate the effectiveness of a new NPWT system specifically used OA resulting from abdominal trauma.
   Methods: A prospective study on trauma patients requiring temporary abdominal closure (TAC) with grade 1 or 2 OA was carried out. All patients were treated with NPWT (RENASYS AB Smith & Nephew) to achieve TAC. The primary outcome measure was time taken to achieve fascial closure and secondary outcomes were complications and mortality.
   Results: A total of 20 patients were included. Thirteen patients (65%) achieved fascial closure following a median treatment period of 3 days. Four patients (20%) died of causes unrelated to NPWT. Complications included fistula formation in one patient (5%) with spontaneous resolution during NPWT), bowel necrosis in a single patient (5%) and three cases of infection (15%). No fistulae were present at the end of NPWT.
   Conclusion: This new NPWT kit is safe and effective and results in a high rate of fascial closure and low complication rates in the severely injured trauma patient.
C1 [Navsaria, Pradeep; Nicol, Andrew; Hudson, Donald] Univ Cape Town, Dept Surg, Groote Schuur Hosp, ZA-7925 Cape Town, South Africa.
   [Cockwill, John] Smith & Nephew, St Petersburg, FL USA.
   [Smith, Jennifer] Smith & Nephew, Kingston Upon Hull HU3 2BN, N Humberside, England.
C3 University of Cape Town; Smith & Nephew; Smith & Nephew
RP Smith, J (通讯作者)，Smith & Nephew, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM jennifer.smith@smith-nephew.com
RI Navsaria, Pradeep/AAS-1807-2020
OI Navsaria, Pradeep/0000-0002-5152-3317
FU Smith Nephew (SN)
FX This study was funded by Smith & Nephew (S&N). Authors JS and JC are
   employees of S&N. DH was part of an International Expert Panel on
   Negative Pressure Wound Therapy funded by an unrestricted educational
   grant provided by Smith & Nephew.
CR [Anonymous], OPEN ABDOMEN TREATME
   [Anonymous], EUR J TRAUMA
   [Anonymous], COLORECTAL DIS OFFIC
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   Cheatham ML, 2007, INTENS CARE MED, V33, P951, DOI 10.1007/s00134-007-0592-4
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   Schmelzle M, 2010, DIGEST SURG, V27, P272, DOI 10.1159/000314609
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NR 26
TC 42
Z9 50
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JAN 10
PY 2013
VL 8
AR 4
DI 10.1186/1749-7922-8-4
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 119DM
UT WOS:000317077600001
PM 23305306
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Deschka, H
   Machner, M
   Wimmer-Greinecker, G
AF Deschka, Heinz
   Machner, Matthias
   Wimmer-Greinecker, Gerhard
TI Presternal False Aneurysm Due to Osseous Arrosion of the Right Ventricle
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE aneurysm; myocardial injury (includes blunt penetrating and iatrogenic);
   sternum; wound healing
ID VACUUM-ASSISTED CLOSURE; STERNAL INFECTION; CARDIAC-SURGERY; RUPTURE
AB Right ventricular rupture after open heart surgery is a rare but severe postoperative complication. In most cases, right ventricular bleeding is associated with mediastinitis and either directly caused by inflammatory processes or iatrogenically through penetration of dehiscent sternal edges or vacuum-assisted closure therapy. We describe a case of right ventricular rupture due to osseous arrosion in a closed chest in the absence of mediastinitis which led to the creation of a massive presternal false aneurysm.
C1 [Deschka, Heinz; Machner, Matthias; Wimmer-Greinecker, Gerhard] Heart & Vessel Ctr Bad Bevensen, Dept Cardiothorac Surg, D-29549 Bad Bevensen, Germany.
RP Deschka, H (通讯作者)，Heart & Vessel Ctr Bad Bevensen, Dept Cardiothorac Surg, Romstedterstr 25, D-29549 Bad Bevensen, Germany.
EM deschkaheinz@hotmail.com
CR Arbulu A, 1996, EUR J CARDIO-THORAC, V10, P110, DOI 10.1016/S1010-7940(96)80132-1
   Bapat V, 2008, J CARDIAC SURG, V23, P227, DOI 10.1111/j.1540-8191.2008.00595.x
   Khoynezhad A, 2004, J CARDIAC SURG, V19, P74, DOI 10.1111/j.0886-0440.2004.04015.x
   Niclauss L, 2010, INTERACT CARDIOV TH, V10, P470, DOI 10.1510/icvts.2009.223891
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   Yellin A, 2003, J THORAC CARDIOV SUR, V125, P554, DOI 10.1067/mtc.2003.31
NR 6
TC 0
Z9 0
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD APR
PY 2013
VL 61
IS 3
BP 261
EP 263
DI 10.1055/s-0032-1327761
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 120MY
UT WOS:000317175800016
PM 23258758
DA 2026-07-24
ER
PT J
AU Grauhan, O
   Navasardyan, A
   Hofmann, M
   Müller, P
   Stein, J
   Hetzer, R
AF Grauhan, Onnen
   Navasardyan, Artashes
   Hofmann, Michael
   Mueller, Peter
   Stein, Julia
   Hetzer, Roland
TI Prevention of poststernotomy wound infections in obese patients by
   negative pressure wound therapy
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID OPEN-HEART-SURGERY; CARDIAC-SURGERY; POSTOPERATIVE MEDIASTINITIS;
   SURGICAL INCISIONS; DEHISCENCE; MANAGEMENT; STERNOTOMY; DEEP
AB Objective: The majority of wound infections after median sternotomy in obese patients are triggered by the breakdown of skin sutures and subsequent seepage of skin flora. The purpose of this study was to evaluate negative pressure wound dressing treatment for the prevention of infection. We hypothesized that negative pressure wound dressing treatment for 6 to 7 days applied immediately after skin closure reduces the numbers of wound infections.
   Methods: In a prospective study, 150 consecutive obese patients (body mass index >= 30) with cardiac surgery performed via median sternotomy were analyzed. In the negative pressure wound dressing treatment group (n = 75), a foam dressing (Prevena, KCI, Wiesbaden, Germany) was placed immediately after skin suturing, and negative pressure of-125 mm Hg was applied for 6 to 7 days. In the control group (n = 75), conventional wound dressings were used. The primary end point was wound infection within 90 days. Mann-Whitney U test and Fisher exact test were used. Freedom from infection was estimated by Kaplan-Meier analysis.
   Results: Three of 75 patients (4%) with continuous negative pressure wound dressing treatment had wound infections compared with 12 of 75 patients (16%) with conventional sterile wound dressing (P = .0266; odds ratio, 4.57; 95% confidence interval, 1.23-16.94). Wound infections with Gram-positive skin flora were found in only 1 patient in the negative pressure wound dressing treatment group compared with 10 patients in the control group (P = .0090; odds ratio, 11.39; 95% confidence interval, 1.42-91.36).
   Conclusions: Negative pressure wound dressing treatment over clean, closed incisions for the first 6 to 7 postoperative days significantly reduces the incidence of wound infection after median sternotomy in a high-risk group of obese patients. (J Thorac Cardiovasc Surg 2013; 145:1387-92)
C1 [Grauhan, Onnen; Navasardyan, Artashes; Hofmann, Michael; Mueller, Peter; Stein, Julia; Hetzer, Roland] Deutsch Herzzentrum Berlin, Dept Cardiothorac & Vasc Surg, D-13353 Berlin, Germany.
C3 German Heart Center Berlin
RP Grauhan, O (通讯作者)，Deutsch Herzzentrum Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM grauhan@dhzb.de
CR [Anonymous], EPIDEMIOLOGY
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NR 22
TC 147
Z9 173
U1 0
U2 16
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD MAY
PY 2013
VL 145
IS 5
BP 1387
EP 1392
DI 10.1016/j.jtcvs.2012.09.040
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 129LJ
UT WOS:000317840600038
PM 23111014
OA Bronze
DA 2026-07-24
ER
PT J
AU Berg, LT
   Jaakkola, P
AF Berg, L. T.
   Jaakkola, P.
TI KUOPIO TREATMENT STRATEGY AFTER DEEP STERNAL WOUND INFECTION
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Deep sternal wound infection; mediastinitis; m. pectoralis major flap;
   m. latissimus dorsi flap; sternotomy; surgical flaps
ID VACUUM-ASSISTED CLOSURE; EMORY 20-YEAR EXPERIENCE; MUSCLE FLAPS;
   CARDIAC-SURGERY; MANAGEMENT; MEDIASTINITIS; THERAPY
AB Backgrounds and Aims: Infection of sternotomy wound is a rare potentially fatal complication because of the risk for deep sternal infection. Current treatment comprises antibiotics, debridement, negative pressure wound therapy and sometimes transposition of muscle or omental flaps to fill the anterior mediastinal dead space.
   Material and Methods: The management of 60 consecutive deep sternotomy wound infections is reviewed. The one stage treatment was mostly chosen. In 5 patients after debridement, negative pressure wound therapy was used before flap reconstruction. Fifty-seven patients were rewired and 3 patients had sternectomy. The choice of the flap was based mainly on anatomic location of a sternal wound defect and also on which grafts been used in cardiac operation.
   Results: The unilateral turnover split pectoralis major flap was the choice for 50 patients. In 8 patients latissimus dorsi flap was used. Rectus abdominis was used as a standalone flap in 4 patients and in combination with pectoralis major in one. All patients survived after deep sternal wound infection. In only 33 patients the recovery was totally uneventful. In the remaining 27 patients there were one or more complications. Not a single flap was lost completely, but due to partial flap necrosis, a redo reconstruction was needed in 3 patients. Negative pressure wound therapy was used after flap reconstruction in eight patients with incomplete post-flap healing to prepare for wound revision and split thickness skin graft.
   Conclusions: A structured approach including both cardiac and plastic surgery in case of deep sternal wound infection is recommended. A single stage surgery with the help of muscle flap reconstruction is our standard treatment. With our protocol, we have been able to keep the mortality low.
C1 [Berg, L. T.] Kuopio Univ Hosp, Dept Plast Surg, SF-70210 Kuopio, Finland.
   [Jaakkola, P.] Kuopio Univ Hosp, Dept Cardiac Surg, SF-70210 Kuopio, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; Kuopio University Hospital
RP Berg, LT (通讯作者)，Univ Kuopio, Cent Hosp, Dept Surg, PostBox 1777, FI-70211 Kuopio, Finland.
EM leena.berg@kuh.fi
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   Vrtik M, 2006, ASIAN CARDIOVASC THO, V14, P14
NR 20
TC 11
Z9 12
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PY 2013
VL 102
IS 1
BP 3
EP 8
DI 10.1177/145749691310200102
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 129YX
UT WOS:000317881000002
PM 23628629
OA Bronze
DA 2026-07-24
ER
PT J
AU Kääriäinen, M
   Kuokkanen, H
AF Kaariainen, M.
   Kuokkanen, H.
TI PRIMARY CLOSURE OF THE ABDOMINAL WALL AFTER "OPEN ABDOMEN" SITUATION
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Abdominal compartment syndrome; open abdomen; primary closure;
   components separation; biologic; synthetic; mesh; perforator saving;
   negative pressure wound therapy; perforator saving components separation
ID ACELLULAR DERMAL MATRIX; ASSISTED WOUND CLOSURE; COMPARTMENT SYNDROME;
   FASCIAL CLOSURE; SEPARATION; RECONSTRUCTION; COMPLEX; REPAIR
AB "Open abdomen" is a strategy used to avoid or treat abdominal compartment syndrome. It has reduced mortality both in trauma and non-trauma abdominal catastrophes but also has created a challenging clinical problem. Traditionally, open abdomen is closed in two phases; primarily with a free skin graft and later with a flap reconstruction. A modern trend is to close the abdomen within the initial hospitalization. This requires multi-professional co-operation. Temporary abdominal closure methods, e.g. negative pressure wound therapy alone or combined with mesh-mediated traction, have been developed to facilitate direct fascial closure. Components separation technique, mesh reinforcement or bridging of the fascial defect with mesh and perforator saving skin undermining can be utilized in the final closure if needed. These techniques can be combined. Choice of the treatment depends on the condition of the patient and size of the fascia and skin defect, and the state of the abdominal contents. In this paper we review the literature on the closure of an open abdomen and present the policy used in our institution in the open abdomen situations.
C1 [Kaariainen, M.; Kuokkanen, H.] Tampere Univ Hosp, Dept Plast Surg, FI-33521 Tampere, Finland.
C3 Tampere University; Tampere University Hospital
RP Kääriäinen, M (通讯作者)，Tampere Univ Hosp, Dept Plast & Reconstruct Surg, POB 2000, FI-33521 Tampere, Finland.
EM minna.t.kaariainen@gmail.com
RI /M-6470-2013
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NR 29
TC 13
Z9 17
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PY 2013
VL 102
IS 1
BP 20
EP 24
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 129YX
UT WOS:000317881000005
PM 23628632
DA 2026-07-24
ER
PT J
AU Thorsteinsson, DT
   Valsson, F
   Geirsson, A
   Gudbjartsson, T
AF Thorsteinsson, David T.
   Valsson, Felix
   Geirsson, Arnar
   Gudbjartsson, Tomas
TI Major cardiac rupture following surgical treatment for deep sternal
   wound infection
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Rupture; Heart; Right ventricle; Deep sternal wound infection; Negative
   pressure wound therapy
AB We report a case of an 80-year old male patient who sustained a major rupture of the right ventricle after surgical revision of an infected sternotomy wound following coronary artery bypass surgery. The rupture of the right ventricle occurred despite an early wound debridement and the use of negative pressure wound therapy on the sternum that did not provide sufficient stability to the sternum after the sternal wires were removed. The rupture resulted in a major bleeding but by establishing emergent cardiopulmonary bypass, the patient was saved.
C1 [Thorsteinsson, David T.; Geirsson, Arnar; Gudbjartsson, Tomas] Landspitali Univ Hosp, Dept Cardiothorac Surg, Reykjavik, Iceland.
   [Valsson, Felix] Landspitali Univ Hosp, Dept Anesthesia & Intens Care, Reykjavik, Iceland.
   [Geirsson, Arnar] Yale Univ, Sect Cardiac Surg, New Haven, CT USA.
   [Gudbjartsson, Tomas] Univ Iceland, Fac Med, Reykjavik, Iceland.
C3 Landspitali National University Hospital; Landspitali National
   University Hospital; Yale University; University of Iceland
RP Gudbjartsson, T (通讯作者)，Landspitali Univ Hosp, Dept Cardiothorac Surg, Reykjavik, Iceland.
EM tomasgud@landspitali.is
RI Thorsteinsson, David/JFB-6115-2023; Geirsson, Arnar/S-4735-2019
OI Thorsteinsson, David/0009-0004-1043-1733; 
CR Arbulu A, 1996, EUR J CARDIO-THORAC, V10, P110, DOI 10.1016/S1010-7940(96)80132-1
   Khoynezhad A, 2004, J CARDIAC SURG, V19, P74, DOI 10.1111/j.0886-0440.2004.04015.x
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   Sjögren J, 2011, INTERACT CARDIOV TH, V12, P117, DOI 10.1510/icvts.2010.252668
   Yellin A, 2003, J THORAC CARDIOV SUR, V125, P554, DOI 10.1067/mtc.2003.31
NR 5
TC 7
Z9 11
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD MAY
PY 2013
VL 16
IS 5
BP 708
EP 709
DI 10.1093/icvts/ivt004
PG 2
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 132UX
UT WOS:000318095300042
PM 23357524
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Reeder, S
   de Roos, KP
   de Maeseneer, M
   Sommer, A
   Neumann, HAM
AF Reeder, S.
   de Roos, K-P.
   de Maeseneer, M.
   Sommer, A.
   Neumann, H. A. M.
TI Ulcer recurrence after in-hospital treatment for recalcitrant venous leg
   ulceration
SO BRITISH JOURNAL OF DERMATOLOGY
LA English
DT Article
ID RISK-FACTORS; TRIAL
AB Background Leg ulceration caused by chronic venous disease occurs in 1% of the adult Western population. A majority of these patients is successfully treated in the outpatient setting. A minority of patients is hospitalized, most frequently because of the lack of healing tendency. The literature provides recurrence rates for ulcer disease, but lacks specific data on recurrence rates after in-hospital treatment of recalcitrant venous leg ulcers. Objectives To investigate time to ulcer recurrence after in-hospital treatment of venous leg ulceration. Methods A multicentre, retrospective cohort study of patients admitted for leg ulceration between 1996 and 2007 was conducted. Results Data could be collected for 107 of the patients. Of these, 27 had conservative treatment (bed rest, local wound care, pain management) and 48 patients underwent surgical ulcer treatment with (n=19) or without (n=29) initial vacuum-assisted closure (VAC) treatment. The treatment method was miscellaneous' in the remaining 32 patients. Median admission time was 30days, median percentage of closure at discharge was 95%, and median time to ulcer recurrence 60days. The MannWhitney U-test showed significant differences between the conservative group and the surgery group, the latter having a longer length of hospital stay (P<0.0001) and a higher percentage of ulcer closure (P<0.0001), but there was no difference in time to ulcer recurrence (P=0.273). Comparable differences were demonstrated between the conservative group and the VAC plus surgery group. No significant differences could be demonstrated between the surgically treated patients and those treated by VAC and surgery. Conclusions Hospital stay is significantly shorter in cases of surgical treatment of recalcitrant venous leg ulcers. Most ulcers recur within 2months after hospital discharge. Recurrence of venous leg ulcers after hospital admission is independent of the method of treatment and cause of ulceration.
C1 [Reeder, S.; de Maeseneer, M.; Neumann, H. A. M.] Erasmus MC, Dept Dermatol, Rotterdam, Netherlands.
   [de Roos, K-P.] DermaPark, Dept Dermatol, Uden, Netherlands.
   [de Maeseneer, M.] Univ Antwerp, Fac Med & Hlth Sci, B-2020 Antwerp, Belgium.
   [Sommer, A.] Reinaert Clin, Dept Dermatol, Maastricht, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; University of Antwerp;
   Maastricht University
RP Reeder, S (通讯作者)，Erasmus MC, Dept Dermatol, Rotterdam, Netherlands.
EM s.reeder@erasmusmc.nl
RI De Maeseneer, Marianne/KBQ-4711-2024
OI De Maeseneer, Marianne/0000-0003-1114-8150
CR Abbade LPF, 2011, INT J DERMATOL, V50, P405, DOI 10.1111/j.1365-4632.2010.04654.x
   [Anonymous], COCHRANE DATABASE SY
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NR 13
TC 12
Z9 19
U1 1
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-0963
J9 BRIT J DERMATOL
JI Br. J. Dermatol.
PD MAY
PY 2013
VL 168
IS 5
BP 999
EP 1002
DI 10.1111/bjd.12164
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 134SC
UT WOS:000318233700013
PM 23253015
DA 2026-07-24
ER
PT J
AU Qu, JF
   Yan, RL
   Wang, L
   Wu, J
   Cao, LH
   Zhao, GZ
   Sun, KY
   Zhang, L
   Du, XJ
   Peng, Y
   Li, SG
   Ma, HD
   Gao, JH
   Liu, HD
AF Qu, Jiafu
   Yan, Rongliang
   Wang, Liang
   Wu, Jun
   Cao, Lihai
   Zhao, Guozhi
   Sun, Kaiyan
   Zhang, Ling
   Du, Xiaojian
   Peng, Yi
   Li, Shaoguang
   Ma, Haidong
   Gao, Jianhua
   Liu, Hongda
TI Free dermatoplasty combined with vacuum sealing drainage for the
   treatment of large-area soft tissue defects accompanied by bone exposure
   in the lower leg
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE vacuum sealing drainage; lower leg; soft tissue trauma defect; bone
   exposure; free dermatoplasty
ID ASSISTED CLOSURE THERAPY; WOUND THERAPY; MANAGEMENT; FRACTURES
AB The aim of this study was to investigate the clinical efficacy of free dermatoplasty combined with vacuum sealing drainage (VSD) for the treatment of large-area soft tissue defects accompanied by bone exposure in the lower leg (crus). Free dermatoplasty combined with VSD was used to treat 36 patients with large-area soft tissue defects accompanied by bone exposure in the lower leg. The areas of the soft tissue defects ranged from 25x12 to 35x30 cm and the areas of exposed bone ranged from 6x4 to 10x6 cm. When evaluated by the open fracture Gustilo classification, 14 cases were of Gustilo type IIIA and 22 cases were of type IIIB. During surgery, adjacent available muscle flaps were transferred to cover the outer areas of the exposed bone and reduce the bone exposure range. Following VSD treatment, granulation tissues grew well and free dermatoplasty combined with VSD was used to treat and repair the wound surfaces. The patients were followed up for 1-5 years (mean duration, 2.5 years). All 36 cases with skin flap grafts survived, the free skin graft texture on the wound surface was good, the recovery of lower limb function was satisfactory and the success rate was 80.56%. Free dermatoplasty combined with VSD used for the treatment of large-area soft tissue defects accompanied by bone exposure in the lower leg may eliminate the need for amputation and complex surgery, and is a simple, fast and effective treatment method.
C1 [Qu, Jiafu; Yan, Rongliang; Wang, Liang; Wu, Jun; Cao, Lihai; Zhao, Guozhi; Sun, Kaiyan; Du, Xiaojian; Peng, Yi; Li, Shaoguang; Ma, Haidong; Gao, Jianhua; Liu, Hongda] Second Hosp Tangshan, Foot & Ankle Surg Inst Tangshan, Dept Foot & Ankle Surg, Tangshan 063000, Hebei, Peoples R China.
   [Zhang, Ling] Tangshan Peoples Hosp, Dept Burn & Plast Surg, Tangshan 063000, Hebei, Peoples R China.
RP Qu, JF (通讯作者)，Second Hosp Tangshan, Foot & Ankle Surg Inst Tangshan, Dept Foot & Ankle Surg, 21 Jianse North Rd, Tangshan 063000, Hebei, Peoples R China.
EM jfhdcn@yeah.net
RI Zhao, Guozhi/HTL-7351-2023
FU Medical Science Research Project of Hebei Province [20090633]
FX This study was supported by the Medical Science Research Project of
   Hebei Province (20090633).
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NR 18
TC 26
Z9 43
U1 0
U2 9
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAY
PY 2013
VL 5
IS 5
BP 1375
EP 1380
DI 10.3892/etm.2013.999
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 136TB
UT WOS:000318385200021
PM 23737883
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Steinkamp, M
   Gress, TM
AF Steinkamp, Martin
   Gress, Thomas M.
TI Endoscopic Options for the Treatment of Anastomotic Leakages in the
   Rectum
SO VISZERALMEDIZIN
LA German
DT Article
DE Anastomotic leakages; Rectum; Endoscopic treatment
ID LOW ANTERIOR RESECTION; TOTAL MESORECTAL EXCISION; ENDO-SPONGE
   TREATMENT; SCOPE CLIP OTSC; MALIGNANT COLONIC OBSTRUCTION; EXPANDABLE
   METALLIC STENT; RISK-FACTORS; FIBRIN GLUE; GASTROINTESTINAL ANASTOMOSES;
   FISTULAS SECONDARY
AB Background: Anastomotic leakages are severe complications in colorectal surgery. Endoscopic treatment techniques have been increasingly established. In this article we present an overview of the most frequently used endoscopic techniques. Methods: Systematic review of the literature. Results: The most relevant endoscopic procedures for the treatment of colorectal anastomotic leakages comprise the injection of fibrin glue, vacuum-assisted closure systems, over-the-scope clips (OTSC), and implantation of self-expanding metal stents. In contrast to the frequent use of these techniques in clinical practice, there is a paucity of evidence from controlled clinical trials supporting the various endosopic techniques. Conclusion: The clinical value of the different methods is mostly dependent on the investigators' experience. Prospective randomized trials are required to generate a valid data basis for the approaches already used in clinical practice.
C1 [Steinkamp, Martin; Gress, Thomas M.] Univ Klinikum Giessen & Marburg GmbH, Klin Gastroenterol Endokrinol Stoffwechsel Infekt, Standort Marburg, Germany.
C3 University Hospital of Giessen & Marburg
RP Steinkamp, M (通讯作者)，Univ Klinikum Giessen & Marburg GmbH, Klin Gastroenterol Endokrinol Stoffwechsel Infekt, Standort Marburg Baldingerstr, D-35037 Marburg, Germany.
EM steinkam@med.uni-marburg.de
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NR 84
TC 2
Z9 2
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-6664
EI 1662-6672
J9 VISZERALMEDIZIN
JI Viszeralmedizin
PY 2012
VL 28
IS 6
BP 369
EP 375
DI 10.1159/000345837
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 137ZR
UT WOS:000318478300002
DA 2026-07-24
ER
PT J
AU Wedemeyer, J
AF Wedemeyer, Jochen
TI Endoscopic Therapy of Esophageal Leakages
SO VISZERALMEDIZIN
LA German
DT Article
DE Esophagus; Anastomotic leakage; Enteral stents; Endoscopic
   vacuum-assisted closure; Clip; Fibrin glue
ID VACUUM-ASSISTED CLOSURE; THORACIC ANASTOMOTIC LEAKS; STENTS;
   PERFORATIONS; MANAGEMENT; FISTULAS; RESECTION; CLIPS
AB Background: Postsurgical leakages after resections of the esophagus are associated with high morbidity and mortality. Methods: Placement of self-expanding stents is the best established endoscopic treatment option for esophageal leakages. A new option comprises the endoscopic placement of vacuum sponge systems. These systems apply the positive effects of negative pressure wound dressings (vacuum-assisted closure, V.A.C.) used for extensive infected skin defects to endoscopically accessible cavities. The development of over-the-scope clips (OTSC) provides another endoscopic treatment modality for esophageal leaks. Results: Leakage closure rates in more than 80% of the cases can be achieved by using these endoscopic techniques. Conclusion: Endoscopic treatment of upper gastrointestinal leakages is the treatment of choice and has almost replaced surgical revision during the last 10 years.
C1 [Wedemeyer, Jochen] Klinikum Reg Hannover GmbH, KRH Klinikum Robert Koch Gehrden, Med Klin Schwerpunkt Gastroenterol & Hepatol 1, D-30989 Gehrden, Germany.
RP Wedemeyer, J (通讯作者)，Klinikum Reg Hannover GmbH, Klinikum Robert Koch Gehrden, Med Klin Schwerpunkt Gastroenterol & Hepatol 1, Von Reden Str 1, D-30989 Gehrden, Germany.
EM jochen.wedemeyer@krh.eu
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   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Wedemeyer J, 2010, GASTROINTEST ENDOSC, V71, P382, DOI 10.1016/j.gie.2009.07.011
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
   Weidenhagen R, 2010, ANN THORAC SURG, V90, P1674, DOI 10.1016/j.athoracsur.2010.07.007
NR 32
TC 2
Z9 2
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-6664
EI 1662-6672
J9 VISZERALMEDIZIN
JI Viszeralmedizin
PY 2012
VL 28
IS 6
BP 376
EP 379
DI 10.1159/000345807
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 137ZR
UT WOS:000318478300003
DA 2026-07-24
ER
PT J
AU Bohn, G
AF Bohn, Gregory
TI Mechanically Powered Ambulatory Negative Pressure Wound Therapy Device
   for Treatment of a Colostomy Takedown Site
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE colostomy; infected wounds; negative pressure wound therapy; ostomy;
   stoma
AB BACKGROUND: The management of postostomy takedown surgical wound sites can be challenging. Complications from these contaminated wounds can lead to serious complications such as hernia formation and increased healthcare costs. Negative pressure wound therapy (NPWT) has been shown to be potentially helpful in managing these heavily colonized wound sites. We report the case of a mechanically powered ambulatory NPWT device (SNaP Wound Care System; Spiracur Inc, Sunnyvale, California) for treating these postcolostomy takedown wounds.
   CASE: A young 9-year-old boy in Port-Au-Prince, Haiti, had under gone colostomy as a protective measure after pelvic fracture 5 months prior. Having healed the pelvic fracture and being fully ambulatory, he underwent takedown of his colostomy with reanastomosis of the bowel. At the completion of surgery, the ostomy wound site was managed by a mechanically powered NPWT device. This allowed the patient to remain ambulatory without the need for attachment to a heavier electrically powered NPWT device during healing. Dressing changes were limited to twice weekly instead of 3 times daily.
   CONCLUSION: This case demonstrates the feasibility of an underdescribed application for a new mechanically powered ambulatory negative pressure device. Findings from this case study suggest that this device may be clinically applicable for patients undergoing ostomy takedown in the United States and in developing nations such as Haiti.
C1 [Bohn, Gregory] Trinity Wound Care & Hyperbar Med, Bettendorf, IA USA.
RP Bohn, G (通讯作者)，4500 Utica Ridge Rd, Bettendorf, IA 52722 USA.
EM gregbohn1@mchsi.com
CR Armstrong DG, 2011, WOUND REPAIR REGEN, V19, P173, DOI 10.1111/j.1524-475X.2010.00658.x
   Gabriel A, 2006, WOUNDS, V18, P245
   Gabriel A, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00628.x
   Kaiser AM, 2008, J GASTROINTEST SURG, V12, P437, DOI 10.1007/s11605-007-0457-8
   Lerman B, 2010, PLAST RECONSTR SURG, V126, P1253, DOI 10.1097/PRS.0b013e3181ea4559
   Lerman Bruce, 2010, J Diabetes Sci Technol, V4, P825
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   Rosen MJ, 2006, J GASTROINTEST SURG, V10, P895, DOI 10.1016/j.gassur.2005.11.008
NR 8
TC 4
Z9 4
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1071-5754
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2013
VL 40
IS 3
BP 315
EP 317
DI 10.1097/WON.0b013e31828f478e
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 142GV
UT WOS:000318786300014
PM 23652704
DA 2026-07-24
ER
PT J
AU Sano, H
   Kajikawa, A
   Ueda, K
AF Sano, Hitomi
   Kajikawa, Akiyoshi
   Ueda, Kazuki
TI Study of continuous irrigation negative-pressure treatment using an
   original ulceration model
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Chronic wound; infection; irrigation
ID VACUUM-ASSISTED CLOSURE; INFECTIONS; WOUNDS
AB A continuous irrigation with intermittent aspiration (CIIA) method has previously been developed in the treatment of infected expander sites. For the purpose of treatment of infected wounds, a new intermittent negative pressure irrigation treatment (INPIT) has been developed that is a combination of CIIA with topical negative-pressure therapy. This study aims to investigate the efficacy of INPIT. The efficacy of irrigation was investigated by changing the conditions including the location and the number of irrigation tubes, flow volume, and the timetable of negative-pressure application using original ulcer models. Although the presence of side holes and increase in the number of tubes or flow volume improved the irrigation efficacy, non-washed-out areas remained. On the other hand, INPIT allowed more uniform and wide area washing even at low flow volume. The results suggest that INPIT is superior to general conventional continuous irrigation treatment in irrigation efficiency.
C1 [Sano, Hitomi; Kajikawa, Akiyoshi; Ueda, Kazuki] Fukushima Med Univ, Dept Plast & Reconstruct Surg, Fukushima 96001295, Japan.
RP Kajikawa, A (通讯作者)，Fukushima Med Univ, Dept Plast & Reconstruct Surg, 1 Hikarigaoka, Fukushima 96001295, Japan.
EM sasasa116sasasa@hotmail.com
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NR 13
TC 1
Z9 2
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD JUN
PY 2013
VL 47
IS 3
BP 175
EP 179
DI 10.3109/2000656X.2012.747961
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 144LO
UT WOS:000318941000003
PM 23676011
OA gold
DA 2026-07-24
ER
PT J
AU Fujiwara, T
   Nishimoto, S
   Ishise, H
   Sotsuka, Y
   Kawai, K
   Fukuda, K
   Kakibuchi, M
AF Fujiwara, Toshihiro
   Nishimoto, Soh
   Ishise, Hisako
   Sotsuka, Yohei
   Kawai, Kenichiro
   Fukuda, Kenji
   Kakibuchi, Masao
TI Influence of continuous or intermittent negative pressure on bacterial
   proliferation potency in vitro
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Negative pressure wound therapy; bacterial proliferation; intermittent
   cycle; continuous mode; Escherichia coli; infected wound
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY
AB Negative pressure wound therapy is helpful and effective in the treatment of intractable skin ulcers and defects, not only acute wounds. However, application of negative pressure wound therapy for an infected wound is still controversial. The authors developed an in-vitro model of negative pressure wound therapy and investigated the influence of various types of negative pressure environment on the proliferation potency of non-pathogenic Escherichia coli. E. coli in Luria-Bertani liquid media was cultured at 37 degrees C under different environments, which were normal atmosphere in group 1, continuous negative pressure of 75 mmHg in group 2, intermittent negative pressure of 75 mmHg with cycle time of 1 minute aspiration and 1 minute abeyance in group 3, with the one of 3 minutes aspiration and 3 minutes abeyance in group 4. The relative amounts of E. coli in each group were investigated at different times. The proliferation potency of E. coli was higher under negative pressure than under normal atmosphere; higher under intermittent negative pressure than under continuous negative pressure; and higher under intermittent negative pressure with a short cycle than with a long cycle. It is important to consider the possibility that the intermittent and continuous mode of negative pressure wound therapy may promote proliferation of bacteria in an infected wound with no blood flow like necrotic tissue.
C1 [Fujiwara, Toshihiro; Nishimoto, Soh; Ishise, Hisako; Sotsuka, Yohei; Kawai, Kenichiro; Fukuda, Kenji; Kakibuchi, Masao] Hyogo Coll Med, Dept Plast & Reconstruct Surg, Nishinomiya, Hyogo 6638501, Japan.
C3 Hyogo Medical University
RP Fujiwara, T (通讯作者)，Hyogo Coll Med, Dept Plast & Reconstruct Surg, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan.
EM fuji-t@hyo-med.ac.jp
OI Sotsuka, Yohei/0000-0003-3871-7886
FU Japanese Ministry of Education, Culture, Sports, Science and Technology
   (MEXT) [22791743]; Hyogo College of Medicine; Grants-in-Aid for
   Scientific Research [22791743] Funding Source: KAKEN
FX This work was supported by Grant-in-Aid for Young Scientists (B)
   (22791743) from the Japanese Ministry of Education, Culture, Sports,
   Science and Technology (MEXT) and Grant-in-Aid for Researchers, Hyogo
   College of Medicine, 2009.
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NR 23
TC 10
Z9 11
U1 1
U2 17
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD JUN
PY 2013
VL 47
IS 3
BP 180
EP 184
DI 10.3109/2000656X.2012.748667
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 144LO
UT WOS:000318941000004
PM 23627563
OA gold
DA 2026-07-24
ER
PT J
AU Carlson, GL
   Patrick, H
   Amin, AI
   McPherson, G
   MacLennan, G
   Afolabi, E
   Mowatt, G
   Campbell, B
AF Carlson, Gordon L.
   Patrick, Hannah
   Amin, Amin I.
   McPherson, Gladys
   MacLennan, Graeme
   Afolabi, Ebenezer
   Mowatt, Graham
   Campbell, Bruce
TI Management of the Open Abdomen A National Study of Clinical Outcome
   and Safety of Negative Pressure Wound Therapy
SO ANNALS OF SURGERY
LA English
DT Article
DE abdominal compartment syndrome; abdominal wall reconstruction;
   intestinal failure; intestinal fistula; laparostomy; negative pressure
   wound therapy; sepsis
ID VACUUM-ASSISTED CLOSURE; TEMPORARY ABDOMINAL CLOSURE; FASCIAL CLOSURE;
   EXPERIENCE; MORTALITY; TRAUMA
AB Objective: To determine clinical outcome of open abdomen therapy and assess the influence of negative pressure wound therapy on outcome.
   Background: Leaving the abdomen open (laparostomy) is an option following laparotomy for severe abdominal sepsis or trauma. Negative pressure wound therapy (NPWT) has become a popular means of managing laparostomy wounds. It may facilitate nursing care and delayed primary wound closure but the evidence to support its use is poor and concern has arisen about the risk of intestinal fistulation from exposed bowel, leading to an increased risk of death.
   Methods: Prospective observational study of 578 patients treated with an open abdomen in 105 hospitals in the United Kingdom between January 1, 2010, and June 30, 2011. Propensity analysis was used to compare adverse outcomes (fistulation, death, intestinal failure, bleeding requiring intervention) and delayed primary closure rates in patients who did and did not receive NPWT.
   Findings: The most common indication for an open abdomen (n = 398, 68.9%) was abdominal sepsis. Overall hospital mortality was 28.2%. The majority of patients (n = 355, 61.4%) were treated with NPWT. Intestinal fistulation [relative risk (RR) = 0.83, 95% confidence interval (CI): 0.44-1.58], death (RR = 0.87, 95% CI: 0.64-1.20), bleeding (RR = 0.74, 95% CI: 0.45-1.23), and intestinal failure (RR = 1.00, 95% CI: 0.64-1.57) were no more common in patients receiving NPWT, but the rate of delayed primary closure was significantly lower (RR = 0.74, 95% CI: 0.60-0.90, P = 0.002) when NPWT was used.
   Conclusions: The indications for an open abdomen in the United Kingdom appear to be significantly different to those described in N. America, where its use in the management of trauma predominates. NPWT in patients with an open abdomen is not associated with an increase in mortality or intestinal fistulation. It is, however, associated with a reduced rate of delayed primary closure. Although this may be related to patient selection, NPWT may leave patients with abdominal wall defects that require further treatment.
C1 [Carlson, Gordon L.] Salford Royal NHS Fdn Trust, Dept Surg, Natl Intestinal Failure Ctr, Salford, Lancs, England.
   [Patrick, Hannah; Campbell, Bruce] Natl Inst Hlth & Clin Excellence, London, England.
   [Amin, Amin I.] Victoria Hosp, Dept Surg, Kirkcaldy, Fife, Scotland.
   [McPherson, Gladys; MacLennan, Graeme; Afolabi, Ebenezer; Mowatt, Graham] Univ Aberdeen, Hlth Serv Res Unit, Aberdeen, Scotland.
   [Campbell, Bruce] Peninsula Coll Med & Dent, Exeter, Devon, England.
C3 Salford Royal NHS Foundation Trust; National Institute for Health & Care
   Excellence; University of Aberdeen; University of Exeter; University of
   Plymouth
RP Carlson, GL (通讯作者)，Salford Royal NHS Fdn Trust, Dept Surg, Eccles Old Rd, Manchester M6 8HD, Lancs, England.
EM gordon.carlson@srft.nhs.uk
OI MacLennan, Graeme/0000-0002-1039-5646; Afolabi,
   Ebenezer/0009-0007-0069-7337
FU National Institute for Health and Clinical Excellence; Chief Scientist
   Office [HSRU1] Funding Source: researchfish
FX This study was supported by National Institute for Health and Clinical
   Excellence. The authors declare no conflicts of interest.
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NR 29
TC 93
Z9 113
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JUN
PY 2013
VL 257
IS 6
BP 1154
EP 1159
DI 10.1097/SLA.0b013e31828b8bc8
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 145VP
UT WOS:000319047300034
PM 23478532
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Hansson, J
   Hlebowicz, J
AF Lindstedt, Sandra
   Hansson, Johan
   Hlebowicz, Joanna
TI The effect of negative wound pressure therapy on haemodynamics in a
   laparostomy wound model
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Haemodynamics; Laparostomy; Negative pressure wound therapy; Wound
   management
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; MICROVASCULAR
   BLOOD-FLOW; OPEN ABDOMEN; INTESTINAL WALL; MANAGEMENT; SEPSIS
AB We have recently shown that negative pressure wound therapy (NPWT) induces a decrease in microvascular blood flow in the small intestinal loop close to the dressing. The effect of NPWT is thus thought to be local. In this study, we investigate whether the application of NPWT in laparostomy affects the haemodynamics. Midline incisions were made in six pigs followed by NPWT at 120 mmHg for 20 minutes. The cardiac output, mean systemic arterial pressure, mean pulmonary artery pressu re, central venous pressure, left atrial pressure and superior mesenteric artery blood flow were recorded. The blood flow in a small branch of the superior mesenteric artery was then recorded under NPWT between 50 and 175 mmHg. Cardiac output was not affected by NPWT [P = not significant (n.s.)]. Neither the mean arterial pressure nor the mean pulmonary artery pressure was affected by NPWT (P = n.s.). Negative pressures of 50, 75, 100 and 125 mmHg did not alter the blood flow in the small branch of the superior mesenteric artery (P = n.s.). After application of 150 mmHg, a significant decrease in blood flow was seen (P < 0 center dot 01), while the application of 175 mmHg resulted in only a slight decrease in blood flow (P = n.s.). The effect of NPWT in laparotomy seems to be local and to have no influence on central haemodynamics or the blood flow to the superior mesenteric artery.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Hansson, Johan] Uppsala Univ, Fac Med, Dept Surg Sci, Uppsala, Sweden.
   [Hlebowicz, Joanna] Malmo Univ Hosp, Dept Med, Lund, Sweden.
C3 Lund University; Skane University Hospital; Uppsala University; Lund
   University; Skane University Hospital
RP Lindstedt, S (通讯作者)，Lund Univ, Skane Univ Hosp, Heart & Lung Ctr, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473
FU Crafoord Foundation; Region Skane
FX This study was supported by the Crafoord Foundation and Region Skane.
CR Andrabi Syed Imran Hussain, 2007, J Ayub Med Coll Abbottabad, V19, P89
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NR 24
TC 4
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2013
VL 10
IS 3
BP 285
EP 290
DI 10.1111/j.1742-481X.2012.00974.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 146CF
UT WOS:000319065700010
PM 22515427
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Fraccalvieri, M
   Sarno, A
   Gasperini, S
   Zingarelli, E
   Fava, R
   Salomone, M
   Bruschi, S
AF Fraccalvieri, Marco
   Sarno, Antonino
   Gasperini, Stefano
   Zingarelli, Enrico
   Fava, Raffaella
   Salomone, Marco
   Bruschi, Stefano
TI Can Single Use Negative Pressure Wound Therapy be an alternative method
   to manage keloid scarring? A preliminary report of a clinical and
   ultrasound/colour-power-doppler study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Compression therapy; Keloid; Mechanic forces; Negative wound pressure
   therapy; Silicone
ID HYPERTROPHIC SCARS; RISK-FACTORS; EFFICACY; PATHOGENESIS; PREVENTION
AB Keloid scarring represents a pathological healing where primary healing phenomenon is deviated from normal. Pico is a single use negative pressure wound therapy system originally introduced to manage open or just closed wounds. Pico dressing is made of silicone, and distributes an 80 mmHg negative pressure across wound bed. Combination of silicon layer and continuous compression could be a valid method to manage keloid scarring. Since November 2011, three patients were enrolled and evaluated before negative pressure treatment, at end of treatment (1 month) and 2 months later, through Vancouver Scar Scale (VSS), Visual Analog Scale (VAS) and a scoring system for itching. Ultrasound (US) and colour-power-doppler (CPD) examination was performed to evaluate thickness and vascularisation of the scar. One patient was discharged from study after 1 week. In last two patients, VSS, VAS and itching significantly improved after 1 month therapy and the results were stable after 2 months without any therapy. At end of therapy, the appearance of palisade vessels' disappeared in both cases at CPD exam; US showed a thickness reduction (average 43 center dot 8%). We propose a well-tolerated, non invasive treatment to manage keloid scarring. Prospective studies are necessary to investigate whether these preliminary observations are confirmed.
C1 [Fraccalvieri, Marco; Zingarelli, Enrico; Salomone, Marco; Bruschi, Stefano] Univ Turin, San Giovanni Battista Hosp, Dept Plast Reconstruct & Aesthet Surg, I-10126 Turin, Italy.
   [Sarno, Antonino] Giovanni Battista Hosp, Radiol Unit, Turin, Italy.
   [Gasperini, Stefano] Univ Pisa, SIRTES Int Sch Wound Repair, Pisa, Italy.
   [Fava, Raffaella] Local Hlth Unit Moncalieri, Turin, Italy.
C3 University of Turin; A.O.U. Citta della Salute e della Scienza di
   Torino; AOU San Giovanni Battista-Molinette; A.O.U. Citta della Salute e
   della Scienza di Torino; AOU San Giovanni Battista-Molinette; University
   of Pisa
RP Fraccalvieri, M (通讯作者)，Univ Turin, San Giovanni Battista Molinette Hosp, Dept Reconstruct & Aesthet Plast Surg, Via Cherasco 23, I-10126 Turin, Italy.
EM marco@fraccalvieri.it
RI /AAF-4387-2019
OI Bruschi, Stefano/0000-0002-4746-9864
CR Agha R, 2011, J SURG RES, V171, P700, DOI 10.1016/j.jss.2011.07.007
   Akaishi S, 2010, PLAST RECONSTR SURG, V126, p109e
   Akaishi S, 2008, ANN PLAS SURG, V60, P445, DOI 10.1097/SAP.0b013e3181238dd7
   Al-Attar A, 2006, PLAST RECONSTR SURG, V117, P286, DOI 10.1097/01.prs.0000195073.73580.46
   Atiyeh BS, 2007, AESTHET PLAST SURG, V31, P468, DOI 10.1007/s00266-006-0253-y
   Baryza Mary Jo, 1995, Journal of Burn Care and Rehabilitation, V16, P535, DOI 10.1097/00004630-199509000-00013
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   BORGOGNONI L, 2000, ANN BURNS FIRE DISAS, V8, P164
   Bush JA, 2011, WOUND REPAIR REGEN, V19, pS32, DOI 10.1111/j.1524-475X.2010.00607.x
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   Ogawa R, 2008, MED HYPOTHESES, V71, P493, DOI 10.1016/j.mehy.2008.05.020
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   Slemp AE, 2006, CURR OPIN PEDIATR, V18, P396, DOI 10.1097/01.mop.0000236389.41462.ef
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   Yagmur C, 2010, PLAST RECONSTR SURG, V126, P426, DOI 10.1097/PRS.0b013e3181df715d
NR 26
TC 13
Z9 17
U1 0
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2013
VL 10
IS 3
BP 340
EP 344
DI 10.1111/j.1742-481X.2012.00988.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 146CF
UT WOS:000319065700018
PM 22716191
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Vos, RJ
   Yilmaz, A
   Sonker, U
   Kloppenburg, GTL
AF Vos, Roemer J.
   Yilmaz, Alaaddin
   Sonker, Uday
   Kloppenburg, Geoffrey T. L.
TI Acute mediastinal bleeding during vacuum-assisted closure
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Bleeding; Complication; Mediastinitis; Vacuum-assisted closure
ID POSTSTERNOTOMY MEDIASTINITIS; SURGERY
AB Vacuum-assisted closure is commonly used to treat post-sternotomy mediastinitis. Several studies show improved outcome using vacuum-assisted therapy; however, risks using negative pressure should not be underestimated. We describe two cases of acute mediastinal bleeding during vacuum treatment for post-sternotomy mediastinitis and discuss preventative measurements.
C1 [Vos, Roemer J.; Yilmaz, Alaaddin; Sonker, Uday; Kloppenburg, Geoffrey T. L.] St Antonius Hosp, Dept Cardiothorac Surg, NL-3435 CM Nieuwegein, Netherlands.
C3 St. Antonius Hospital Utrecht
RP Kloppenburg, GTL (通讯作者)，St Antonius Hosp, Dept Cardiothorac Surg, Koekoekslaan 1, NL-3435 CM Nieuwegein, Netherlands.
EM geoffrey_kloppenburg@hotmail.com
OI Vos, Roemer/0000-0002-2511-988X
CR Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
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   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
NR 8
TC 5
Z9 6
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2013
VL 10
IS 3
BP 348
EP 350
DI 10.1111/j.1742-481X.2012.00989.x
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 146CF
UT WOS:000319065700020
PM 22630562
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Roberts, DJ
   Jenne, CN
   Ball, CG
   Tiruta, C
   Léger, C
   Xiao, ZW
   Faris, PD
   McBeth, PB
   Doig, CJ
   Skinner, CR
   Ruddell, SG
   Kubes, P
   Kirkpatrick, AW
AF Roberts, Derek J.
   Jenne, Craig N.
   Ball, Chad G.
   Tiruta, Corina
   Leger, Caroline
   Xiao, Zhengwen
   Faris, Peter D.
   McBeth, Paul B.
   Doig, Christopher J.
   Skinner, Christine R.
   Ruddell, Stacy G.
   Kubes, Paul
   Kirkpatrick, Andrew W.
TI Efficacy and safety of active negative pressure peritoneal therapy for
   reducing the systemic inflammatory response after damage control
   laparotomy (the Intra-peritoneal Vacuum Trial): study protocol for a
   randomized controlled trial
SO TRIALS
LA English
DT Article
DE Abdominal injuries; Damage control laparotomy; Inflammation; Negative
   pressure wound therapy; Randomized controlled trial; Sepsis; Temporary
   abdominal closure; Wounds and injuries
ID TEMPORARY ABDOMINAL CLOSURE; PLANNED RELAPAROTOMY; COMPARTMENT SYNDROME;
   ORGAN DYSFUNCTION; ASSISTED CLOSURE; CYTOKINE RELEASE; PACK TECHNIQUE;
   SEPTIC SHOCK; OPEN ABDOMEN; ON-DEMAND
AB Background: Damage control laparotomy, or abbreviated initial laparotomy followed by temporary abdominal closure (TAC), intensive care unit resuscitation, and planned re-laparotomy, is frequently used to manage intraabdominal bleeding and contamination among critically ill or injured adults. Animal data suggest that TAC techniques that employ negative pressure to the peritoneal cavity may reduce the systemic inflammatory response and associated organ injury. The primary objective of this study is to determine if use of a TAC dressing that affords active negative pressure peritoneal therapy, the ABThera Open Abdomen Negative Pressure Therapy System, reduces the extent of the systemic inflammatory response after damage control laparotomy for intra-abdominal sepsis or injury as compared to a commonly used TAC method that provides potentially less efficient peritoneal negative pressure, the Barker's vacuum pack.
   Methods/ Design: The Intra-peritoneal Vacuum Trial will be a single-center, randomized controlled trial. Adults will be intraoperatively allocated to TAC with either the ABThera or Barker's vacuum pack after the decision has been made by the attending surgeon to perform a damage control laparotomy. The study will use variable block size randomization. On study days 1, 2, 3, 7, and 28, blood will be collected. Whenever possible, peritoneal fluid will also be collected at these time points from the patient's abdomen or TAC device. Luminex technology will be used to quantify the concentrations of 65 mediators relevant to the inflammatory response in peritoneal fluid and plasma. The primary endpoint is the difference in the plasma concentration of the pro-inflammatory cytokine IL-6 at 24 and 48 h after TAC dressing application. Secondary endpoints include the differential effects of these dressings on the systemic concentration of other pro-inflammatory cytokines, collective peritoneal and systemic inflammatory mediator profiles, postoperative fluid balance, intra-abdominal pressure, and several patient-important outcomes, including organ dysfunction measures and mortality.
   Discussion: Results from this study will improve understanding of the effect of active negative pressure peritoneal therapy after damage control laparotomy on the inflammatory response. It will also gather necessary pilot information needed to inform design of a multicenter trial comparing clinical outcomes among patients randomized to TAC with the ABThera versus Barker's vacuum pack.
C1 [Roberts, Derek J.; Ball, Chad G.; Kirkpatrick, Andrew W.] Univ Calgary, Dept Surg, Calgary, AB T2N 2T9, Canada.
   [Roberts, Derek J.; Ball, Chad G.; Tiruta, Corina; Xiao, Zhengwen; Faris, Peter D.; Kirkpatrick, Andrew W.] Foothills Med Ctr, Calgary, AB T2N 2T9, Canada.
   [Roberts, Derek J.; Faris, Peter D.; Doig, Christopher J.] Univ Calgary, Dept Community Hlth Sci, Div Epidemiol, Calgary, AB T2N 4Z6, Canada.
   [Roberts, Derek J.; Faris, Peter D.; Doig, Christopher J.] Univ Calgary, Dept Community Hlth Sci, Div Biostat, Calgary, AB T2N 4Z6, Canada.
   [Jenne, Craig N.; Leger, Caroline; Doig, Christopher J.; Skinner, Christine R.; Ruddell, Stacy G.; Kubes, Paul; Kirkpatrick, Andrew W.] Univ Calgary, Dept Crit Care Med, Calgary, AB T2N 5A1, Canada.
   [Jenne, Craig N.; Leger, Caroline; Doig, Christopher J.; Skinner, Christine R.; Ruddell, Stacy G.; Kubes, Paul; Kirkpatrick, Andrew W.] Foothills Med Ctr, Calgary, AB T2N 5A1, Canada.
   [Ball, Chad G.] Univ Calgary, Dept Oncol, Calgary, AB T2N 2T9, Canada.
   [Ball, Chad G.; Tiruta, Corina; Xiao, Zhengwen; Kirkpatrick, Andrew W.] Univ Calgary, Reg Trauma Program, Calgary, AB T2N 2T9, Canada.
   [Faris, Peter D.] Univ Calgary, Alberta Hlth Serv, Res Excellence Support Team, Calgary, AB T2N 2T9, Canada.
   [Kubes, Paul] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada.
   [Jenne, Craig N.; Leger, Caroline; Kubes, Paul] Foothills Med Ctr, Hlth Res Innovat Ctr, Calgary, AB T2N 4N1, Canada.
   [Jenne, Craig N.; Leger, Caroline; Kubes, Paul] Univ Calgary, Calvin Phoebe & Joan Snyder Inst Chron Dis, Calgary, AB T2N 4N1, Canada.
   [McBeth, Paul B.] Univ British Columbia, Dept Med, Div Crit Care Med, Vancouver, BC V6Z 1Y6, Canada.
   [McBeth, Paul B.] St Pauls Hosp, Vancouver, BC V6Z 1Y6, Canada.
C3 University of Calgary; University of Calgary; University Calgary
   Hospital; University of Calgary; University of Calgary; University of
   Calgary; University of Calgary; University Calgary Hospital; University
   of Calgary; University of Calgary; Alberta Health Services (AHS);
   University of Calgary; University of Calgary; University of Calgary;
   University Calgary Hospital; University of Calgary; University of
   British Columbia; St. Paul's Hospital
RP Kirkpatrick, AW (通讯作者)，Univ Calgary, Dept Surg, North Tower 10th Floor,1403-29th St Northwest, Calgary, AB T2N 2T9, Canada.
EM Andrew.Kirkpatrick@albertahealthservices.ca
RI Doig, Christopher/AAC-7949-2020; Jenne, Craig/HCH-3413-2022; Faris,
   Peter/AAJ-3436-2020; Roberts, Derek/L-6229-2019
OI Faris, Peter/0000-0001-5208-817X; Roberts, Derek/0000-0001-6111-6291
FU Alberta Innovates - Health Solutions Clinician Fellowship Award;
   Knowledge Translation Canada Strategic Training in Health Research
   Fellowship; Clinician Investigator and Surgeon Scientist Programs at the
   University of Calgary; University of Calgary
FX DJR is supported by an Alberta Innovates - Health Solutions Clinician
   Fellowship Award, a Knowledge Translation Canada Strategic Training in
   Health Research Fellowship, and funding from the Clinician Investigator
   and Surgeon Scientist Programs at the University of Calgary. CL and CNJ
   are supported by the Calvin, Phoebe and Joan Snyder Chair in Critical
   Care Medicine based at the University of Calgary and awarded to PK. AWK
   has an investigator-initiated trial funding agreement with Kinetic
   Concepts Incorporated (KCI) USA and the Governors of the University of
   Calgary for the clinical and laboratory costs of conducting the study
   (KCI contract number: KCI
   Clinical/UniversityCalgaryAlbertaHealth/082611-000/7). KCI USA will have
   no role in the design or conduct of the study; collection, management,
   analysis, or interpretation of the data; or preparation, review, or
   approval of the manuscript. The remaining authors have no competing
   interests to declare. We would like to thank Anita Verdonk, RN, BScN,
   CEN, ET, who was formerly a clinical therapies specialist with KCI
   Medical Canada Inc., for providing technical information on the ABThera
   (TM) device. We would also like to thank Sandy Cochrane at Multimedia
   Services, University of Calgary for assistance with creation of the
   illustrations of the ABThera T and Barker's vacuum pack.
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NR 83
TC 22
Z9 31
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD MAY 16
PY 2013
VL 14
AR 141
DI 10.1186/1745-6215-14-141
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 150NT
UT WOS:000319398500001
PM 23680127
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Trevillyan, JM
   Johnson, PDR
AF Trevillyan, Janine M.
   Johnson, Paul D. R.
TI Steroids control paradoxical worsening of Mycobacterium ulcerans
   infection following initiation of antibiotic therapy
SO MEDICAL JOURNAL OF AUSTRALIA
LA English
DT Article
ID DIAGNOSIS
AB A 19-year-old man with a 3-month history of a non-healing ulcer of the right knee and indurated oedema involving the entire lower leg (Box 1) presented after not responding to multiple courses of antibiotics. A punch biopsy showed necrosis of the dermis and subcutaneous tissues, and extensive infiltration with extracellular acid-fast bacilli on auramine-rhodamine staining. Potymerase chain reaction (PCR) testing for the 152404 insertion sequence of Mycobacterium ulcerans was positive,(1) and M. ulcerans was isolated from culture at 6 weeks. The patient reported holidaying on the Bellarine Peninsula, an endemic area for M. ulcerans, 6 months before the development of the lesion. Surgical intervention was deferred due to the extensive area involved and World Health Organization guidelines suggesting antibiotics as first-line treatment for extensive oedematous disease.(2) He commenced oral daily rifampicin (600 mg) and moxifloxacin (400 mg) and, within a week, noted a marked decrease in. exudate and improvement in the painful oedematous disease of the lower leg. Therapy was well tolerated and the ulcer remained stable with only one small area of new skin loss lateral to the primary lesion.
   Four weeks later, there was a rapid deterioration in clinical condition, with fevers, sweats, anorexia and a recurrence of lower limb oedema and pain. Significant skin breakdown occurred around the ulcer and distally on the leg, with copious serous exudate (Box 2). Full blood examination showed a neutrophilia (neutrophil count, 14.9x10(9)/L [reference interval, 1.9-8.0x10(9)/L]) and a raised C-reactive protein level (69.8 mg/L [reference interval, <3 mg/L]). Prednisolone 50 mg daily and intravenous piperacillin tazobactam 4.5 g three times daily was commenced. An ultrasound of the Limb showed extensive liquefaction of the subcutaneous fat, and swabs were PCR-positive for M. ulcerans but culture-negative following prolonged incubation.
   Within 12 hours of commencing prednisolone therapy (combined with broad-spectrum antibiotics), the patient became afebrile, with neutrophil and C-reactive protein levels within reference intervals on full blood examination and an improvement in ulcer appearance. He was discharged on a 25 mg maintenance dose of prednisolone white continuing rifampicin and moxifloxacin. Increasing areas of skin loss and exudate,developed when prednisolone was decreased to 12.5 mg daily, and thus he underwent a limited debridement of the lateral knee and negative-pressure wound therapy (VAC GranuFoam dressing, KCI Medical), followed by successful split skin grafting., Heat therapy (Bair Hugger, 3M Arizant Healthcare) was used to maintain skin temperature at 39 degrees C.
   Prednisolone was continued for 2 weeks postoperatively (15 mg daily) and then stopped without further deterioration in the patient's condition. The patient completed a 3-month course of antimycobacterial antibiotics, at which time there was no sign of ongoing infection. Two skin sites subsequently discharged a small amount of culture-negative material but, at 12 months, there was no evidence of microbiological relapse.
C1 [Trevillyan, Janine M.; Johnson, Paul D. R.] Austin Hlth, Dept Infect Dis, Melbourne, Vic, Australia.
   [Johnson, Paul D. R.] Victorian Infect Dis Reference Lab, WHO Collaborating Ctr Mycobacterium Ulcerans West, Melbourne, Vic, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Austin Research Institute; Victorian Infectious
   Diseases Reference Laboratory
RP Trevillyan, JM (通讯作者)，Austin Hlth, Dept Infect Dis, Melbourne, Vic, Australia.
EM janine.trevillyan@monash.edu
RI Trevillyan, Janine/AAD-1631-2019
OI Trevillyan, Janine/0000-0002-8660-5558
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NR 10
TC 13
Z9 15
U1 0
U2 8
PU AUSTRALASIAN MED PUBL CO LTD
PI PYRMONT
PA LEVEL 2, 26-32 PYRMONT BRIDGE RD, PYRMONT, NSW 2009, AUSTRALIA
SN 0025-729X
J9 MED J AUSTRALIA
JI Med. J. Aust.
PD MAY 6
PY 2013
VL 198
IS 8
BP 443
EP 444
DI 10.5694/mja12.11559
PG 2
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 153RR
UT WOS:000319620700020
PM 23641997
DA 2026-07-24
ER
PT J
AU Dorafshar, AH
   Franczyk, M
   Karian, L
   Teven, C
   Wroblewski, K
   Gottlieb, LJ
   Lohman, RF
AF Dorafshar, Amir H.
   Franczyk, Mieczyslawa
   Karian, Laurel
   Teven, Chad
   Wroblewski, Kristen
   Gottlieb, Lawrence J.
   Lohman, Robert F.
TI A Prospective Randomized Trial Comparing Subatmospheric Wound Therapy
   With a Sealed Gauze Dressing and the Standard Vacuum-Assisted Closure
   Device: A Supplementary Subgroup Analysis of Infected Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE subatmospheric pressure wound therapy; vacuum-assisted closure; gauze
   dressing with suction; infection
ID TOPICAL TREATMENT; INSTILLATION; SYSTEM; DEFECT; PAIN
AB Introduction. Subatmospheric pressure wound therapy (SAWT) is commonly used to manage infected wounds. However, this practice remains controversial because the safety and efficacy of the technique has not been carefully documented. Methods. The authors assessed the safety and efficacy of a sealed gauze dressing with wall suction applied (GSUC) compared to vacuum assisted-closure (VAC), both soaked with topical antimicrobials. Subjects included 31 hospitalized patients with acutely infected wounds compared with 56 patients with noninfected wounds. Results. There were significant reductions in wound surface area and volume in both infected and noninfected groups; there was no significant difference in the rate of change observed in the GSUC vs the VAC arms of the study. In the infected group, the reduction in wound surface area was 4.4% per day for GSUC and 4.8% per day for VAC. Wound volume was 7.8% per day for GSUC, and 9.7% per day for VAC (P < 0.001 for all). Evidence of wound infection in all patients, regardless of treatment group, resolved by 96 hours of onset of treatment, and there were no complications specifically related to the use of a sealed dressing over infected wounds. Conclusion. Gauze dressing with wall suction and VAC therapy can be used in selected acute, infected wounds and both methods of treatment appear to be similarly effective for reducing wound surface area and volume.
C1 [Dorafshar, Amir H.; Franczyk, Mieczyslawa; Teven, Chad; Gottlieb, Lawrence J.] Univ Chicago, Plast & Reconstruct Surg Sect, Chicago, IL 60637 USA.
   Univ Chicago, Dept Therapy Serv, Chicago, IL 60637 USA.
   [Karian, Laurel] Univ Med & Dent New Jersey, Div Plast Surg, Newark, NJ 07103 USA.
   [Wroblewski, Kristen] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA.
   [Lohman, Robert F.] Cleveland Clin, Dept Plast Surg, Cleveland, OH 44106 USA.
C3 University of Chicago; University of Chicago; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences; University of Chicago; Cleveland Clinic Foundation
RP Lohman, RF (通讯作者)，Cleveland Clin Fdn, Dept Plast, 9500 Euclid Ave,Desk A-60, Cleveland, OH 44195 USA.
EM robert.lohman@case.edu
RI Teven, Chad/HKO-4889-2023; Dorafshar, Amir/AAP-2657-2021
OI Dorafshar, Amir/0000-0001-7045-3601
FU University of Chicago
FX This study was funded by the Dean and Barbara White Fund, The University
   of Chicago. The authors report no affiliation with KCI, manufacturer of
   the pressure wound therapy device tested in this study.
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NR 47
TC 3
Z9 3
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2013
VL 25
IS 5
BP 121
EP 130
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 154CL
UT WOS:000319649000004
PM 25866892
DA 2026-07-24
ER
PT J
AU Sagar, S
   Kumar, S
   Gupta, A
   Singhal, M
   Mishra, B
AF Sagar, Sushma
   Kumar, Subodh
   Gupta, Amit
   Singhal, Maneesh
   Mishra, Biplab
TI Successful Management of a Case of Primary Cutaneous Mucormycosis in an
   Immunocompetent Host
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE cutaneous mucormycosis; vacuum-assisted closure; immunocompetent host
ID ZYGOMYCOSIS; INFECTIONS; THERAPY
AB Primary cutaneous mucormycosis is a rare disease in the immunocompetent, and research on this condition is limited to case reports. Clinical presentation is not sufficiently distinctive to allow a diagnosis and the immunocompetent state precludes even the suspicion of the condition. There is agreement in literature regarding the absence of guidelines for its treatment. Most reports have used a combination of aggressive and repeated surgical debridement and systemic antifungals, usually amphotericin B. The authors propose the use of vacuum-assisted closure technology in managing these wounds with a possible role in decreasing the number and extent of debridement and limiting deeper tissue damage.
C1 [Sagar, Sushma; Kumar, Subodh; Gupta, Amit; Singhal, Maneesh; Mishra, Biplab] All India Inst Med Sci, Jai Prakash Narayan Apex Trauma Ctr, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; Jai Prakash
   Narayan Apex Trauma Center
RP Kumar, S (通讯作者)，All India Inst Med Sci, Jai Prakash Narayan Apex Trauma Ctr, Room 306, New Delhi 110029, India.
EM subodh6@gmail.com
RI sagar, sushma/K-5397-2019; Kumar, Subodh/JYP-8905-2024
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NR 24
TC 0
Z9 1
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2013
VL 25
IS 5
BP 136
EP 140
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 154CL
UT WOS:000319649000006
PM 25866894
DA 2026-07-24
ER
PT J
AU Falagas, ME
   Tansarli, GS
   Kapaskelis, A
   Vardakas, KZ
AF Falagas, Matthew E.
   Tansarli, Giannoula S.
   Kapaskelis, Anastasios
   Vardakas, Konstantinos Z.
TI Impact of Vacuum-Assisted Closure (VAC) Therapy on Clinical Outcomes of
   Patients with Sternal Wound Infections: A Meta-Analysis of
   Non-Randomized Studies
SO PLOS ONE
LA English
DT Article
ID TOPICAL NEGATIVE-PRESSURE; LONG-TERM SURVIVAL; SUCTION DRAINAGE;
   CARDIAC-SURGERY; MANAGEMENT; MEDIASTINITIS; MORTALITY; TRIAL; COST
AB Objective: To examine the impact of VAC therapy on mortality of patients with sternal wound infections after cardiothoracic surgery.
   Summary Background Data: Controversial results regarding mortality of patients with sternal wound infections were published.
   Methods: We performed a systematic search in PubMed and Scopus. Mortality was the primary outcome of the meta-analysis. Recurrences, complications and length of stay were secondary outcomes.
   Results: Twenty-two retrospective studies including 2467 patients were eligible for inclusion. Patients treated with VAC had significantly lower mortality compared to those treated without VAC [2233 patients, RR = 0.40, (95% CI 0.28, 0.57)]. This finding was consistent regardless of the study design, the exclusion of studies with positive findings, the criteria for establishment of the compared groups, the time of mortality assessment or the type of infections under study, provided that adequate data was available. VAC therapy was associated with fewer recurrences (RR = 0.34, 95% CI: 0.19-0.59). The meta-analysis did not show any difference in the length of stay (RR = -2.25, 95% CI: -7.52-3.02).
   Conclusions: VAC therapy was associated with lower mortality than other surgical techniques in retrospective cohorts of patients with DSWIs following cardiothoracic surgery.
C1 [Falagas, Matthew E.; Tansarli, Giannoula S.; Kapaskelis, Anastasios; Vardakas, Konstantinos Z.] Alfa Inst Biomed Sci, Athens, Greece.
   [Falagas, Matthew E.; Kapaskelis, Anastasios; Vardakas, Konstantinos Z.] Mitera Hosp, Hygeia Grp, Dept Internal Med Infect Dis, Athens, Greece.
   [Falagas, Matthew E.] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA.
C3 Alfa Institute Of Biomedical Sciences; Tufts University
RP Falagas, ME (通讯作者)，Alfa Inst Biomed Sci, Athens, Greece.
EM m.falagas@aibs.gr
RI /M-5253-2019
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Assmann A, 2011, THORAC CARDIOV SURG, V59, P25, DOI 10.1055/s-0030-1250598
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   Berg HF, 2000, ANN THORAC SURG, V70, P924, DOI 10.1016/S0003-4975(00)01524-1
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   Segers Patrique, 2005, Interact Cardiovasc Thorac Surg, V4, P555, DOI 10.1510/icvts.2005.112714
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   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   Soares MO, 2012, MED DECIS MAKING
   Sood Smita, 2012, Indian J Community Med, V37, P39, DOI 10.4103/0970-0218.94023
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   van Wingerden JJ, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-121
   Vos RJ, 2012, EUR J CARDIOTHORAC S
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 41
TC 29
Z9 33
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 31
PY 2013
VL 8
IS 5
AR e64741
DI 10.1371/journal.pone.0064741
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 156DC
UT WOS:000319799900092
PM 23741379
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Blackham, AU
   Farrah, JP
   McCoy, TP
   Schmidt, BS
   Shen, P
AF Blackham, Aaron U.
   Farrah, Jason P.
   McCoy, Thomas P.
   Schmidt, Benjamin S.
   Shen, Perry
TI Prevention of surgical site infections in high-risk patients with
   laparotomy incisions using negative-pressure therapy
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Negative-pressure therapy; Surgical site infections; Prevention;
   Laparotomy; Quality improvement
ID VACUUM-ASSISTED CLOSURE; COLORECTAL SURGERY; BOWEL PREPARATION; WOUND
   INFECTIONS; RANDOMIZED-TRIAL; COLLAGEN SPONGE; FOLLOW-UP; PROPHYLAXIS;
   REDUCTION; GUIDELINE
AB BACKGROUND: This study evaluates the efficacy of negative-pressure therapy (NPT) in preventing surgical site infections (SSIs) in high-risk surgical oncology patients.
   METHODS: A retrospective analysis of 191 operations for colorectal, pancreatic, or peritoneal surface malignancies was performed. Incisional NPT was used in patients with multiple SSI risk factors. Rates of SSIs were compared with patients treated with a standard sterile dressing (SSD).
   RESULTS: NPT was used in 104 patients, whereas SSDs were used in 87 patients. Despite being at an increased risk of SSI, patients treated with NPT developed fewer superficial incisional SSIs compared with SSD patients (6.7% vs 19.5%, P = .015). In a subgroup analysis of clean-contaminated cases, NPT was associated with fewer superficial incisional SSIs (6.0% vs 27.4%, P - .001), fewer total SSIs (16.0% vs 35.5%, P = .011), and fewer wound openings for any reason (16.0% vs 35.5%, P = .011).
   CONCLUSIONS: Our findings suggest that NPT decreases SSIs in high-risk surgical oncology patients. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Blackham, Aaron U.; Farrah, Jason P.; Schmidt, Benjamin S.; Shen, Perry] Wake Forest Sch Med, Dept Gen Surg, Winston Salem, NC 27157 USA.
   [McCoy, Thomas P.] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest University
RP Shen, P (通讯作者)，Wake Forest Sch Med, Dept Gen Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM pshen@wakehealth.edu
RI ; McCoy, Thomas P/PGU-0093-2026
OI Schmidt, Benjamin/0000-0002-4947-2725; McCoy, Thomas
   P/0000-0003-4813-1248
CR [Anonymous], SURG SIT INF PREV TR
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NR 40
TC 96
Z9 116
U1 0
U2 8
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD JUN
PY 2013
VL 205
IS 6
BP 647
EP 654
DI 10.1016/j.amjsurg.2012.06.007
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 156DY
UT WOS:000319802500005
PM 23375758
DA 2026-07-24
ER
PT J
AU Fluieraru, S
   Bekara, F
   Naud, M
   Herlin, C
   Faure, C
   Trial, C
   Téot, L
AF Fluieraru, S.
   Bekara, F.
   Naud, M.
   Herlin, C.
   Faure, C.
   Trial, C.
   Teot, L.
TI Sterile-water negative pressure instillation therapy for complex wounds
   and NPWT failures
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE instillation; negative pressure therapy; complex wounds; granulation
   tissue formation; surgical closure
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; FOAM
AB Objective: To investigate use of negative pressure wound therapy (NPWT) combined with instillation for patients either presenting with a complex wound or after failure of classic NPWT.
   Method: A retrospective case series study conducted on patients treated using an NPWT instillation system (V.A.C. Instill; KCI Inc.) from January to December 2012. The instillation machine was used with pure saline so as not to interfere with local antibacterial solutions. Two clinical indications-patients presenting either large undermining, deep inaccessible wounds or infected wounds and those for whom conventional NPWT had proved ineffective, were analysed-with efficacy of the promotion of granulation tissue as the primary outcome. Length of instillation time, the rhythm and the amount of liquid to be injected compared with the estimated volume of the cavity were also evaluated.
   Results: Twenty-four patients were included in this series-12 post-NPWT failures and 12 complex wounds-with positive outcomes in 23 cases. Surgical closure was realised after promotion of granulation tissue, using either flaps or skin grafts alone, or combined with previous application of a dermal substitute. No complications linked to instillation were observed during the period of use.
   Conclusion: The results of this case series suggests that use of NPWT combined with pure saline instillation could have a positive impact on the healing trajectory of patients with complex wounds or after failure of classic NPWT.
C1 [Fluieraru, S.; Bekara, F.; Herlin, C.; Trial, C.; Teot, L.] Montpellier Univ Hosp, Dept Surg, Wound Healing Unit, Pole EMMBRUN, Montpellier, France.
   [Naud, M.; Faure, C.] Montpellier Univ Hosp, Med Device Unit, Dept Pharm, Montpellier, France.
C3 Universite de Montpellier; CHU de Montpellier; Universite de
   Montpellier; CHU de Montpellier
RP Fluieraru, S (通讯作者)，Montpellier Univ Hosp, Dept Surg, Wound Healing Unit, Pole EMMBRUN, Montpellier, France.
EM l-teot@chu-montpellier.fr
CR [Anonymous], COCHRANE DATABASE SY
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NR 23
TC 41
Z9 58
U1 0
U2 4
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2013
VL 22
IS 6
BP 293
EP 299
DI 10.12968/jowc.2013.22.6.293
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 157BX
UT WOS:000319871500002
PM 24049811
DA 2026-07-24
ER
PT J
AU Heiney, J
   Redfern, R
AF Heiney, J.
   Redfern, R.
TI Difficult leg wounds successfully closed with decortication,
   bioresorbable ECM and NPWT
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE compartment syndrome; decortication; negative pressure wound therapy;
   wound complications
ID VACUUM-ASSISTED CLOSURE; ACUTE COMPARTMENT SYNDROME; THERAPY; TRIAL;
   MULTICENTER; MANAGEMENT; FRACTURES; SMOKING; ULCERS; RISK
AB Complications of a missed compartment syndrome are severe. This case demonstrates the difficulty in dealing with such complications, including the difficult situation of being faced with limb salvage when amputation is the best option. Through a short case description and several images, it is demonstrated how even the most difficult wounds in cases like this can be dealt with and achieve a non-painful limb salvage. In particular, an extreme technique of decorticating the bone and applying bioresorbable extracellular matrix with negative pressure wound therapy was applied in order to achieve final wound closure and pain relief. This case demonstrates integration of multiple modalities for complex wound closure.
C1 [Heiney, J.] Univ Toledo, Med Ctr, Dept Orthopaed, Toledo, OH 43606 USA.
   [Redfern, R.] Toledo Hosp, Sponsored Res Dept, Toledo, OH USA.
C3 University System of Ohio; University of Toledo
RP Heiney, J (通讯作者)，Univ Toledo, Med Ctr, Dept Orthopaed, Toledo, OH 43606 USA.
EM jakeheiney@ameritech.net
OI Redfern, Roberta/0000-0001-9883-2910
CR [Anonymous], 2009, Sources: 2009 data are projections from the 2007 California Health Interview Survey; California Department of Finance population estimates; Medi-Cal, Healthy Families and Medicare administrative data; and 2010 California Health Benefits Review Program Estimates of Sources of Health Insurance in California
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NR 26
TC 3
Z9 5
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2013
VL 22
IS 6
BP 314
EP 316
DI 10.12968/jowc.2013.22.6.314
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 157BX
UT WOS:000319871500006
PM 24049815
DA 2026-07-24
ER
PT J
AU Brangewitz, M
   Voigtländer, T
   Helfritz, FA
   Lankisch, TO
   Winkler, M
   Klempnauer, J
   Manns, MP
   Schneider, AS
   Wedemeyer, J
AF Brangewitz, M.
   Voigtlaender, T.
   Helfritz, F. A.
   Lankisch, T. O.
   Winkler, M.
   Klempnauer, J.
   Manns, M. P.
   Schneider, A. S.
   Wedemeyer, J.
TI Endoscopic closure of esophageal intrathoracic leaks: stent versus
   endoscopic vacuum-assisted closure, a retrospective analysis
SO ENDOSCOPY
LA English
DT Article
ID THORACIC ANASTOMOTIC LEAKS; PRESSURE WOUND THERAPY; GASTRIC-CARCINOMA;
   PLASTIC STENTS; PERFORATIONS; MANAGEMENT
AB Background and study aim: Placement of covered self-expanding metal or plastic stents (SEMS or SEPS) is an established method for managing intrathoracic leaks. Recently, endoscopic vacuum-assisted closure (EVAC) has been described as a new effective treatment option. Our aim was to compare stent placement with EVAC for nonsurgical closure of intrathoracic anastomotic leaks.
   Patients and methods: In a retrospective analysis we were able to identify 39 patients who were treated with SEMS or SEPS and 32 patients who were treated with EVAC for intrathoracic leakage. In addition to successful fistula closure, we analyzed hospital mortality, number of endoscopic interventions, incidence of stenoses, and duration of hospitalization.
   Results: In a multivariate analysis, successful wound closure was independently associated with EVAC therapy (hazard ratio 2.997, 95% confidence interval [95%CI] 1.568 - 5.729; P = 0.001). The overall closure rate was significantly higher in the EVAC group (84.4%) compared with the SEMS/SEPS group (53.8%). No difference was found for hospitalization and hospital mortality. We found significantly more strictures in the stent group (28.2% vs. 9.4% with EVAC, P < 0,05).
   Conclusions: EVAC is an effective endoscopic treatment option for intrathoracic leaks and showed higher effectiveness than stent placement in our cohort.
C1 [Brangewitz, M.; Voigtlaender, T.; Lankisch, T. O.; Manns, M. P.; Schneider, A. S.; Wedemeyer, J.] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany.
   [Helfritz, F. A.; Winkler, M.; Klempnauer, J.] Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, Hannover, Germany.
   [Wedemeyer, J.] Robert Koch Hosp, Dept Internal Med, Gehrden, Germany.
C3 Hannover Medical School; Hannover Medical School
RP Wedemeyer, J (通讯作者)，Gehrden Klinikum Reg Hannover, Dept Internal Med, Robert Koch Hosp, Von Reden Str 1, D-30989 Gehrden, Germany.
EM jochen.wedemeyer@krh.eu
RI Manns, Michael/AFG-3063-2022
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NR 22
TC 190
Z9 229
U1 0
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0013-726X
EI 1438-8812
J9 ENDOSCOPY
JI Endoscopy
PD JUN
PY 2013
VL 45
IS 6
BP 433
EP 438
DI 10.1055/s-0032-1326435
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 157RH
UT WOS:000319916300007
PM 23733727
DA 2026-07-24
ER
PT J
AU Shankaran, V
   Brooks, M
   Mostow, E
AF Shankaran, Vidya
   Brooks, Megan
   Mostow, Eliot
TI Advanced therapies for chronic wounds: NPWT, engineered skin, growth
   factors, extracellular matrices
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE extracellular matrix; growth factors; negative pressure wound therapy;
   wounds; wound care
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; CHRONIC LEG ULCERS;
   VENOUS LEG; DOUBLE-BLIND; MULTICENTER; EFFICACY; SAFETY; APLIGRAF(R);
   TRIAL
AB Advanced wound care implies the use of products or procedures that are specialized. Although dermatologists are used to being specialists of the skin, hair, and nails, chronic wound care has evolved such that there are some specific treatment options that are more commonly ordered and performed in wound care clinics. Wound care clinics are staffed by specialists and generalists including dermatologists, but also orthopedic surgeons, vascular surgeons, infectious disease specialists, internists, family practitioners, hyperbaric oxygen-trained physicians from a variety of backgrounds, podiatrists, physician assistants, and nurse practitioners. The care of chronic wounds has almost become its own specialty, with so-called advanced therapies now including the use of growth factors, extracellular matrices, engineered skin, and negative pressure wound therapy. It is critical that the dermatologists understand the treatments such that they can appropriately apply or order them directly, or be involved with the care of their patients receiving these therapies.
C1 [Shankaran, Vidya] Summa Hlth Syst, Akron, OH USA.
   [Brooks, Megan; Mostow, Eliot] Akron Gen Med Ctr, Akron, OH USA.
   [Mostow, Eliot] Northeast Ohio Med Univ, Rootstown, OH USA.
   [Mostow, Eliot] Case Western Sch Med, Cleveland, OH 44320 USA.
C3 Summa Health System; Akron General Medical Center; University System of
   Ohio; Northeast Ohio Medical University (NEOMED); University System of
   Ohio; Case Western Reserve University
EM emostow@neomed.edu
RI Brooks, Megan/JMC-6016-2023
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NR 37
TC 33
Z9 41
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD MAY-JUN
PY 2013
VL 26
IS 3
SI SI
BP 215
EP 221
DI 10.1111/dth.12050
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 159GV
UT WOS:000320034800005
PM 23742282
DA 2026-07-24
ER
PT J
AU Hsu, CC
   Chow, SE
   Chen, CPC
   Tsai, WC
   Wang, JS
   Yu, SY
   Lee, SC
AF Hsu, Chih-Chin
   Chow, Shu-Er
   Chen, Carl Pai-Chu
   Tsai, Wen-Chung
   Wang, Jong-Shyan
   Yu, Shin-Ying
   Lee, Sheng-Chi
TI Negative pressure accelerated monolayer keratinocyte healing involves
   Cdc42 mediated cell podia formation
SO JOURNAL OF DERMATOLOGICAL SCIENCE
LA English
DT Article
DE Negative-pressure wound therapy; Wound healing; Cell movement; Actins
ID VACUUM-ASSISTED CLOSURE; ENDOTHELIAL-CELLS; WOUND THERAPY; ACTIN;
   PROLIFERATION; MECHANISMS; VIABILITY; MIGRATION; NETWORKS; DYNAMICS
AB Background: Negative-pressure wound therapy (NPWT) is developed to facilitate wound healing at controlled subatmospheric pressures in modern medicine. Molecular mechanism for this therapy is still undefined.
   Objective: This study highlights the localization and time-course of the cell division control protein 42 (Cdc42) in the cell membrane at ambient pressure (AP) and negative pressures of 75 mmHg (NP75), 125 mmHg (NP125) and 175 mmHg (NP175).
   Methods: The prepared cells were cultured in a negative pressure incubator with the same O-2 and CO2 tensions at the four different pressures. The effective time, complete wound closure time, cell volume, cell viability, and the fluorescence of proliferating cell nuclear antigens (PCNA) and actins were evaluated in cells at different pressures. Wound-healing process and Cdc42 fluorescence were examined in cells with the knockdown of Cdc42. Cdc42 pathway proteins in cell membranes were analyzed after incubation at different pressures for 6 and 12 h.
   Results: The cells at NP125 had less wound closure time and obvious cell podia. Similar PCNA fluorescent intensity was observed in cells at different pressures. The Cdc42, neural Wiskott-Aldrich syndrome protein, and actin expression increased significantly (p < 0.05) in plasma membranes of cells at NP125 for 12 h. The knockdown of active Cdc42 resulted in the absence of Cdc42 expression at the cell leading edge.
   Conclusions: The activation and localization of Cdc42 pathway proteins in the cell membrane are involved in the cell podia formation in keratinocytes at NP125. NPWT may facilitate cell migration to accelerate wound healing. (c) 2013 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Hsu, Chih-Chin; Yu, Shin-Ying; Lee, Sheng-Chi] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Keelung 20401, Taiwan.
   [Hsu, Chih-Chin; Tsai, Wen-Chung] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Tao Yuan, Taiwan.
   [Chow, Shu-Er] Chang Gung Univ, Coll Med, Ctr Gen Studies, Tao Yuan, Taiwan.
   [Chen, Carl Pai-Chu; Tsai, Wen-Chung] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Tao Yuan, Taiwan.
   [Wang, Jong-Shyan] Chang Gung Univ, Inst Rehabil Sci, Coll Med, Tao Yuan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung
   University; Chang Gung Memorial Hospital; Chang Gung University
RP Hsu, CC (通讯作者)，Chang Gung Mem Hosp, Dept Phys Med & Rehabil, 222 Maijin Rd, Keelung 20401, Taiwan.
EM steele0618@gmail.com
OI Wang, Jong-Shyan/0000-0002-3095-9357
FU Chang Gung Memorial Hospital, Keelung [CMRPG290401]
FX We thank the Chang Gung Memorial Hospital, Keelung, for a Grant
   (CMRPG290401) to support this study.
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NR 34
TC 22
Z9 25
U1 0
U2 14
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0923-1811
EI 1873-569X
J9 J DERMATOL SCI
JI J. Dermatol. Sci.
PD JUN
PY 2013
VL 70
IS 3
BP 196
EP 203
DI 10.1016/j.jdermsci.2013.03.007
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 160UO
UT WOS:000320146200007
PM 23622765
DA 2026-07-24
ER
PT J
AU Nuutila, K
   Siltanen, A
   Peura, M
   Harjula, A
   Nieminen, T
   Vuola, J
   Kankuri, E
   Aarnio, P
AF Nuutila, Kristo
   Siltanen, Antti
   Peura, Matti
   Harjula, Ari
   Nieminen, Tapio
   Vuola, Jyrki
   Kankuri, Esko
   Aarnio, Pertti
TI Gene expression profiling of negative-pressure-treated skin graft donor
   site wounds
SO BURNS
LA English
DT Article
DE Wound healing; Gene expression; Epidermis; Dermis
ID VACUUM-ASSISTED CLOSURE; THERAPY
AB Negative-pressure wound therapy (NPWT) is Widely used to improve skin wound healing. Although NPWT has been studied as a treatment for wound closure and healing, the molecular mechanisms explaining its therapeutic effects remain unclear. To investigate the effect of NPWT on gene expression, and to discover the genes most dominantly responding to this treatment during skin wound healing, we applied negative pressure on split-thickness skin graft donor sites from the first postoperative day (POD) to the seventh POD. Biopsies were collected from 4 NPWT-treated and 2 control patients. Two biopsy samples were taken from each patient: one from intact skin before graft harvesting, and one on the seventh POD from the donor site wound. Genome-wide microarrays were performed on all samples. Gene expression changes on the seventh POD were compared between NPWT and control patients, and were analyzed for statistical significance. In addition, we analyzed wound exudates for volume, and for concentrations of leukocytes, erythrocytes, and haemoglobin. NPWT induced major changes in gene expression during healing. These changes ranged from 10-fold induction to 27-fold suppression. The genes most induced were associated with cell proliferation and inflammation, and the most down-regulated genes were linked to epidermal differentiation. Our results provide the first insight into the molecular mechanisms behind NPWT, and suggest that NPWT enhances specific inflammatory gene expression at the acute phase associated with epithelial migration and wound healing. However, its continued use may inhibit epithelial differentiation. (c) 2012 Elsevier Ltd and ISBI. All rights reserved.
C1 [Nuutila, Kristo; Siltanen, Antti; Peura, Matti; Harjula, Ari; Kankuri, Esko] Univ Helsinki, Inst Biomed, FIN-00290 Helsinki, Finland.
   [Harjula, Ari] Univ Helsinki, Meilahti Hosp, Dept Cardiothorac Surg, FIN-00290 Helsinki, Finland.
   [Nieminen, Tapio; Aarnio, Pertti] Satakunta Cent Hosp, Dept Surg, Pori 28500, Finland.
   [Vuola, Jyrki] Univ Helsinki, Cent Hosp, Toolo Hosp, Helsinki Burn Ctr, Helsinki 00260, Finland.
C3 University of Helsinki; University of Helsinki; Satakunta Central
   Hospital; University of Helsinki; Helsinki University Central Hospital;
   Hyvinkaan Sairaala
RP Nuutila, K (通讯作者)，Univ Helsinki, Inst Biomed, POB 63, FIN-00014 Helsinki, Finland.
EM kristo.nuutila@helsinki.fi
RI Kankuri, Esko/AGF-5256-2022
OI Kankuri, Esko/0000-0002-2193-8773; harjula, ari/0000-0001-6691-3636
FU Finnish Funding Agency for Technology and Innovation (TEKES),
   Regenerative Active Matrix (RAM) [40102/08]
FX Lahja Eurajoki (Helsinki), Leena Liljeroos (Pori), and Ulla
   Hohtari-Kivimaki (Pori) are gratefully acknowledged for their skilful
   technical assistance. We thank Hannu Kuokkanen and Ilkka Kaartinen for
   kind assistance with the ethics permits. The project was funded by the
   Finnish Funding Agency for Technology and Innovation (TEKES),
   Regenerative Active Matrix (RAM) project (40102/08).
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NR 30
TC 36
Z9 41
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD JUN
PY 2013
VL 39
IS 4
BP 687
EP 693
DI 10.1016/j.burns.2012.09.014
PG 7
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 161RC
UT WOS:000320210000022
PM 23141686
DA 2026-07-24
ER
PT J
AU Kirkpatrick, AW
   Roberts, DJ
   De Waele, J
   Jaeschke, R
   Malbrain, MLNG
   De Keulenaer, B
   Duchesne, J
   Bjorck, M
   Leppaniemi, A
   Ejike, JC
   Sugrue, M
   Cheatham, M
   Ivatury, R
   Ball, CG
   Blaser, AR
   Regli, A
   Balogh, ZJ
   D'Amours, S
   Debergh, D
   Kaplan, M
   Kimball, E
   Olvera, C
AF Kirkpatrick, Andrew W.
   Roberts, Derek J.
   De Waele, Jan
   Jaeschke, Roman
   Malbrain, Manu L. N. G.
   De Keulenaer, Bart
   Duchesne, Juan
   Bjorck, Martin
   Leppaniemi, Ari
   Ejike, Janeth C.
   Sugrue, Michael
   Cheatham, Michael
   Ivatury, Rao
   Ball, Chad G.
   Blaser, Annika Reintam
   Regli, Adrian
   Balogh, Zsolt J.
   D'Amours, Scott
   Debergh, Dieter
   Kaplan, Mark
   Kimball, Edward
   Olvera, Claudia
CA Pediat Guidelines Sub-Comm World
TI Intra-abdominal hypertension and the abdominal compartment syndrome:
   updated consensus definitions and clinical practice guidelines from the
   World Society of the Abdominal Compartment Syndrome
SO INTENSIVE CARE MEDICINE
LA English
DT Article
DE Intra-abdominal hypertension; Abdominal compartment syndrome; Critical
   care; Grading of Recommendations; Assessment, Development, and
   Evaluation; Evidence-based medicine; World Society of the Abdominal
   Compartment Syndrome
ID DAMAGE CONTROL RESUSCITATION; VACUUM-ASSISTED CLOSURE; CRITICALLY-ILL
   PATIENTS; OPEN ABDOMEN; INTERNATIONAL-CONFERENCE; PRESSURE MEASUREMENT;
   FASCIAL CLOSURE; VENTRAL HERNIA; RISK-FACTORS; MANAGEMENT
AB To update the World Society of the Abdominal Compartment Syndrome (WSACS) consensus definitions and management statements relating to intra-abdominal hypertension (IAH) and the abdominal compartment syndrome (ACS).
   We conducted systematic or structured reviews to identify relevant studies relating to IAH or ACS. Updated consensus definitions and management statements were then derived using a modified Delphi method and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) guidelines, respectively. Quality of evidence was graded from high (A) to very low (D) and management statements from strong RECOMMENDATIONS (desirable effects clearly outweigh potential undesirable ones) to weaker SUGGESTIONS (potential risks and benefits of the intervention are less clear).
   In addition to reviewing the consensus definitions proposed in 2006, the WSACS defined the open abdomen, lateralization of the abdominal musculature, polycompartment syndrome, and abdominal compliance, and proposed an open abdomen classification system. RECOMMENDATIONS included intra-abdominal pressure (IAP) measurement, avoidance of sustained IAH, protocolized IAP monitoring and management, decompressive laparotomy for overt ACS, and negative pressure wound therapy and efforts to achieve same-hospital-stay fascial closure among patients with an open abdomen. SUGGESTIONS included use of medical therapies and percutaneous catheter drainage for treatment of IAH/ACS, considering the association between body position and IAP, attempts to avoid a positive fluid balance after initial patient resuscitation, use of enhanced ratios of plasma to red blood cells and prophylactic open abdominal strategies, and avoidance of routine early biologic mesh use among patients with open abdominal wounds. NO RECOMMENDATIONS were possible regarding monitoring of abdominal perfusion pressure or the use of diuretics, renal replacement therapies, albumin, or acute component-parts separation.
   Although IAH and ACS are common and frequently associated with poor outcomes, the overall quality of evidence available to guide development of RECOMMENDATIONS was generally low. Appropriately designed intervention trials are urgently needed for patients with IAH and ACS.
C1 [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Surg, Calgary, AB T2N 2T9, Canada.
   [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Crit Care Med, Calgary, AB T2N 2T9, Canada.
   [Kirkpatrick, Andrew W.] Foothills Med Ctr, Reg Trauma Serv, Calgary, AB T2N 2T9, Canada.
   [Roberts, Derek J.] Univ Calgary, Dept Surg, Calgary, AB T2N 5A1, Canada.
   [Roberts, Derek J.] Univ Calgary, Dept Community Hlth Sci, Calgary, AB T2N 5A1, Canada.
   [De Waele, Jan] Ghent Univ Hosp, Dept Crit Care Med, Ghent, Belgium.
   [De Waele, Jan] Ghent Med Sch, Ghent, Belgium.
   [Jaeschke, Roman] McMaster Univ, Dept Med, Hamilton, ON L8P 3B6, Canada.
   [Jaeschke, Roman] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON L8P 3B6, Canada.
   [Malbrain, Manu L. N. G.] Ziekenhuis Netwerk Antwerpen, ZNA Stuivenberg, Intens Care Unit, B-2060 Antwerp 6, Belgium.
   [Malbrain, Manu L. N. G.] Ziekenhuis Netwerk Antwerpen, ZNA Stuivenberg, High Care Burn Unit, B-2060 Antwerp 6, Belgium.
   [De Keulenaer, Bart; Regli, Adrian] Fremantle Hosp, Intens Care Unit, Fremantle, WA 6959, Australia.
   [Duchesne, Juan] Tulane Surg Intens Care Unit, Div Surg Anesthesia & Emergency Med, Sect Trauma & Crit Care Surg, New Orleans, LA 70112 USA.
   [Bjorck, Martin] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
   [Leppaniemi, Ari] Univ Helsinki, Meilahti Hosp, Dept Abdominal Surg, Helsinki 00029, Finland.
   [Ejike, Janeth C.] Loma Linda Univ Childrens Hosp, Loma Linda, CA USA.
   [Sugrue, Michael] Letterkenny Hosp, Donegal, Ireland.
   [Sugrue, Michael] Donegal Clin Res Acad, Donegal, Ireland.
   [Sugrue, Michael] Univ Coll Hosp, Galway, Ireland.
   [Cheatham, Michael] Orlando Reg Med Ctr Inc, Dept Surg Educ, Orlando, FL 32806 USA.
   [Ivatury, Rao] Virginia Commonwealth Univ, Med Coll Virginia, Richmond, VA 23298 USA.
   [Ball, Chad G.] EG 23 Foothills Med Ctr, Reg Trauma Serv, Calgary, AB T2N 2T9, Canada.
   [Blaser, Annika Reintam] Univ Tartu, Clin Anaesthesiol & Intens Care, EE-51014 Tartu, Estonia.
   [Regli, Adrian] Univ Western Australia, Sch Med & Pharmacol, Crawley, WA 6009, Australia.
   [Regli, Adrian] Univ Notre Dame, Sch Med, Fremantle, WA 6959, Australia.
   [Balogh, Zsolt J.] Univ Newcastle, John Hunter Hosp, Newcastle, NSW 2310, Australia.
   [D'Amours, Scott] Liverpool Hosp, Trauma Dept, Liverpool, Nsw Bc 2170, Australia.
   [Debergh, Dieter] Ghent Univ Hosp, Dept Intens Care, B-9000 Ghent, Belgium.
   [Kaplan, Mark] Albert Einstein Med Ctr, Philadelphia, PA 19141 USA.
   [Kimball, Edward] Univ Utah, Dept Surg, Salt Lake City, UT USA.
   [Olvera, Claudia] Univ Anahuac, Amer British Cowdray Med Ctr, Mexico City, DF, Mexico.
C3 University of Calgary; University Calgary Hospital; University of
   Calgary; University Calgary Hospital; University of Calgary; University
   Calgary Hospital; University of Calgary; University of Calgary; Ghent
   University; Ghent University Hospital; Ghent University; McMaster
   University; McMaster University; ZNA Stuivenberg; ZNA Stuivenberg; South
   Metropolitan Health Service; Fiona Stanley Fremantle Hospitals Group;
   Fremantle Hospital; University of Western Australia; Tulane University;
   Uppsala University; University of Helsinki; Helsinki University Central
   Hospital; Loma Linda University; Ollscoil na Gaillimhe-University of
   Galway; Orlando Health; Orlando Regional Medical Center; Virginia
   Commonwealth University; University of Tartu; University of Western
   Australia; The University of Notre Dame Australia; John Hunter Hospital;
   University of Newcastle; Liverpool Hospital; Ghent University; Ghent
   University Hospital; Yeshiva University; Utah System of Higher
   Education; University of Utah; Universidad Anahuac
RP Kirkpatrick, AW (通讯作者)，Foothills Med Ctr, Dept Surg, Calgary, AB T2N 2T9, Canada.
EM Andrew.kirkpatrick@albertahealthservices.ca; Derek.Roberts01@gmail.com;
   jan.dewaele@UGent.be; jaeschke@mcmaster.ca; manu.malbrain@skynet.be;
   bdekeul@hotmail.com; jduchesn@tulane.edu; martin@bjorck.pp.se;
   ari.leppaniemi@hus.fi; jejike@llu.edu; acstrauma@hotmail.com;
   Michael.cheatham@orlandohealth.com; rivatury@mcvh-vcu.edu;
   ball.chad@gmail.com; annika.reintam.blaser@ut.ee;
   Adrian.regli@gmail.com; Zsolt.balogh@hne.health.nsw.gov.au;
   Scott.Damours@swsahs.nsw.gov.au; dieter.debergh@UGent.be;
   kaplanm@einstein.edu; Edward.kimball@hsc.utah.edu; claudia_olvera@me.com
RI De Waele, Jan/E-2704-2013; Roberts, Derek/L-6229-2019; Malbrain,
   Manu/B-3680-2017; Leppäniemi, Ari/GQZ-7991-2022; Ivatury,
   Rao/H-2922-2019; Balogh, Zsolt/A-2002-2010; Jaeschke,
   Roman/ABW-5103-2022; Bjorck, Martin/A-4104-2008; Reintam Blaser,
   Annika/M-1573-2013
OI De Waele, Jan/0000-0003-1017-9748; D'Amours, Scott/0009-0004-4975-7984;
   Roberts, Derek/0000-0001-6111-6291; Regli, Adrian/0000-0002-3960-6013;
   Malbrain, Manu/0000-0002-1816-5255; Reintam Blaser,
   Annika/0000-0003-1211-7372
FU Alberta Innovates-Health Solutions Clinician Fellowship Award; Clinician
   Investigator Program at the University of Calgary; World Society of the
   Abdominal Compartment Syndrome
FX Dr. Roberts is supported by an Alberta Innovates-Health Solutions
   Clinician Fellowship Award and funding from the Clinician Investigator
   Program at the University of Calgary. We thank Gordon Guyatt, MD, MSc,
   Department of Medicine, McMaster University, Hamilton, Ontario, Canada
   L8P 3B6, Department of Clinical Epidemiology and Biostatistics, McMaster
   University for methodological guidance. We also thank Ms. Michelle
   Mercado and Ms. Alma Rados of the Trauma Association of Canada for
   web-hosting and editing. This manuscript was commissioned and supported
   by the World Society of the Abdominal Compartment Syndrome
   (www.wsacs.org).
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NR 96
TC 1033
Z9 1374
U1 3
U2 97
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0342-4642
EI 1432-1238
J9 INTENS CARE MED
JI Intensive Care Med.
PD JUL
PY 2013
VL 39
IS 7
BP 1190
EP 1206
DI 10.1007/s00134-013-2906-z
PG 17
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 163KF
UT WOS:000320334100003
PM 23673399
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Morris, MW
   Westmoreland, T
   Sawaya, DE
   Blewett, CJ
AF Morris, Michael W., Jr.
   Westmoreland, Tamarah
   Sawaya, David E.
   Blewett, Christopher J.
TI Staged closure with negative pressure wound therapy for gastroschisis
   with liver herniation: A case report
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Gastroschisis; Liver herniation; Negative pressure wound therapy
ID RISK STRATIFICATION
AB Liver herniation with gastroschisis is an uncommon occurrence that is associated with a poor prognosis. This report presents a single case of complex gastroschisis complicated by herniation of the left hepatic lobe. In the subject case, the abdominal wall defect was successfully closed by sequential closure with negative pressure wound therapy after the initial application of a preformed silo. As there are no established standards for the management of gastroschisis with liver herniation, there exists an opportunity for multicenter review to define approaches to optimize clinical outcomes with this complex congenital issue. As a result of the complexity and rarity of this congenital abnormality, reports with a positive prognosis carry clinical relevance. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Morris, Michael W., Jr.] Univ Mississippi, Sch Med, Dept Surg, Jackson, MS 39216 USA.
   [Westmoreland, Tamarah; Sawaya, David E.; Blewett, Christopher J.] Univ Mississippi, Sch Med, Dept Surg, Div Pediat Surg, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi; University of Mississippi Medical Center
RP Morris, MW (通讯作者)，Univ Mississippi, Sch Med, Dept Surg, Jackson, MS 39216 USA.
EM mmorrisjr@umc.edu
OI Westmoreland, Tamarah/0000-0003-2912-1298
CR Alvarez SM, 2007, J PEDIATR SURG, V42, P943, DOI 10.1016/j.jpedsurg.2007.01.026
   Arnold MA, 2007, J PEDIATR SURG, V42, P1520, DOI 10.1016/j.jpedsurg.2007.04.032
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NR 10
TC 2
Z9 4
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD MAY
PY 2013
VL 48
IS 5
BP E13
EP E15
DI 10.1016/j.jpedsurg.2013.03.005
PG 3
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 163XP
UT WOS:000320372100004
PM 23701801
DA 2026-07-24
ER
PT J
AU Pauli, EM
   Krpata, DM
   Novitsky, YW
   Rosen, MJ
AF Pauli, Eric M.
   Krpata, David M.
   Novitsky, Yuri W.
   Rosen, Michael J.
TI Negative Pressure Therapy for High-Risk Abdominal Wall Reconstruction
   Incisions
SO SURGICAL INFECTIONS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; SURGICAL SITE
   INFECTION; VENTRAL HERNIA REPAIR; WOUND THERAPY; CARDIAC-SURGERY;
   FRACTURES; MULTICENTER; PREDICTORS; MANAGEMENT
AB Background: A high rate of surgical site infection (SSI) accompanies the repair of large ventral hernias in the presence of bacterial contamination. Recent clinical and laboratory studies suggest that negative-pressure therapy (NPT) applied to closed surgical incisions may reduce the risk of SSI in high-risk populations. We hypothesized that NPT would reduce the risk of SSI in patients undergoing the repair of contaminated ventral hernias.
   Methods: We reviewed retrospectively our prospectively collected database for patients undergoing repair of potentially contaminated and infected ventral hernias with or without NPT. All of the patients had primary wound closure. In the NPT group, a vacuum dressing was applied over the closed midline wound. The primary outcome measure was SSI at 30 d post-operatively.
   Results: We evaluated 119 patients (70 with a standard wound dressing (SWD) and 49 with NPT). The groups were similar in age, gender, body mass index (BMI), the prevalence of chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), and smoking; and the number of prior abdominal operations. The SWD group had a higher American Society of Anesthesiologists (ASA) score than did the NPT group (3.0 vs. 2.8; p = 0.01). The two groups were similar in the sizes of their hernia defects and duration of surgery, and did not differ in their 30-d rates of SSI (25.8% SWD vs. 20.4% NPT; p = 0.50) or in the distribution of major and minor SSIs (SWD: 6 major, 12 minor vs. NPT: 2 major, 8 minor; p = 0.56). Factors associated with an increased risk of SSI included ASA score (p = 0.02), BMI (p = 0.05), defect area (p < 0.01), DM (p = 0.01), and duration of surgery, (p < 0.01).
   Conclusions: This retrospective, non-randomized study found that NPT in the setting of a closed surgical incision after potentially contaminated or infected ventral hernia repair (VHR) did not reduce the incidence of SSI. Although prophylactic NPT has reduced wound morbidity in some surgical populations, it does not appear to offer the same reduction in wound morbidity in high-risk, contaminated, and potentially contaminated open VHR.
C1 [Pauli, Eric M.; Krpata, David M.; Novitsky, Yuri W.; Rosen, Michael J.] Univ Hosp Case Med Ctr, Case Comprehens Hernia Ctr, Dept Surg, Cleveland, OH USA.
C3 University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital
RP Rosen, MJ (通讯作者)，11100 Euclid Ave,Mail Stop LKS 5047, Cleveland, OH 44106 USA.
EM Michael.Rosen@uhhospitals.org
RI Rosen, Michael/ABA-0409-2022
FU Lifecell, Inc.; Davol, Inc.; W.L. Gore, Inc. (Newark, DE); Cook Group,
   Inc. (Bloomington, IN)
FX Yuri Novitsky serves as a speaker for Lifecell, Inc. (Branchburg, NJ),
   and Davol, Inc. (Warwick, RI), and as a consultant for Davol and for
   Kensey-Nash, Inc. (Exton, PA). Michael Rosen serves as a speaker for
   Lifecell, Inc., and receives research support from Lifecell, Inc.,
   Davol, Inc., W.L. Gore, Inc. (Newark, DE), and the Cook Group, Inc.
   (Bloomington, IN). None of the other authors have relationships to
   disclose.
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NR 34
TC 52
Z9 55
U1 0
U2 11
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
J9 SURG INFECT
JI Surg. Infect.
PD JUN
PY 2013
VL 14
IS 3
BP 270
EP 274
DI 10.1089/sur.2012.059
PG 5
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA 168LD
UT WOS:000320706300003
PM 23590852
DA 2026-07-24
ER
PT J
AU Sziklavari, Z
   Grosser, C
   Neu, R
   Schemm, R
   Szöke, T
   Ried, M
   Hofmann, HS
AF Sziklavari, Zsolt
   Grosser, Christian
   Neu, Reiner
   Schemm, Rudolf
   Szoeke, Tamas
   Ried, Michael
   Hofmann, Hans-Stefan
TI Minimally invasive vacuum-assisted closure therapy in the management of
   complex pleural empyema
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Empyema; Minimally invasive surgery; VAC therapy; Wound closure
ID OPEN-WINDOW THORACOSTOMY; INTRATHORACIC APPLICATION; DEVICE
AB OBJECTIVES: The pool of potential candidates for pleural empyema is expanding. In a previous technical report, we tested the feasibility of the minimally invasive insertion of a vacuum-assisted closure (Mini-VAC) system without the insertion of an open-window thoracostomy (OWT). In this study, we describe a consecutive case series of complex pleural empyemas that were managed by this Mini-VAC therapy.
   METHODS: In this retrospective study, we investigated 6 patients with multimorbidity (Karnofsky index <= 50%) who were consecutively treated with Mini-VAC for a primary, postoperative or recurrent pleural empyema between January 2011 and February 2012.
   RESULTS: Local control of the infection and control of sepsis were satisfactory in all 6 of the patients treated by Mini-VAC therapy. The suction used did not create any air leaks or bleeding from the lung or mediastinal structures. Mini-VAC therapy allowed a reduction of the empyema cavity and improved the re-expansion of the residual lung. Mini-VAC therapy resulted in a rapid eradication of the empyema. The chest wall was closed in all patients during the first hospital stay. All patients left the hospital in good health (Karnofsky index > 70%) and with a non-infected pleural cavity at a mean of 22 +/- 11 days after Mini-VAC installation. Pleural empyema was not detected in any of the 6 patients at the 3-month follow-up appointment.
   CONCLUSIONS: The Mini-VAC procedure with the abdication of an OWT offers a rapid treatment for complex pleural empyema with minimal surgical effort and the opportunity for a primary closure of the empyema cavity.
C1 [Sziklavari, Zsolt; Grosser, Christian; Schemm, Rudolf; Szoeke, Tamas; Hofmann, Hans-Stefan] Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, D-93049 Regensburg, Germany.
   [Neu, Reiner; Ried, Michael; Hofmann, Hans-Stefan] Univ Regensburg, Dept Thorac Surg, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Hofmann, HS (通讯作者)，Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, Prufeningerstr 86, D-93049 Regensburg, Germany.
EM hans-stefan.hofmann@barmherzige-regensburg.de
RI Sziklavari, Zsolt/AGI-2440-2022; Ried, Michael/AAC-4518-2022
OI Ried, Michael/0000-0002-2365-4803
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NR 12
TC 21
Z9 26
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUL
PY 2013
VL 17
IS 1
BP 49
EP 53
DI 10.1093/icvts/ivt093
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 170NI
UT WOS:000320858900012
PM 23536021
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Park, JK
   Lee, JH
   Kwak, JJ
   Shin, HB
   Jung, HW
   Bae, SW
   Yeo, ED
   Lee, YK
   Yang, SS
AF Park, Jun Kyu
   Lee, Jong Hoon
   Kwak, Jeong Ja
   Shin, Hee Bong
   Jung, Hae Won
   Bae, Sang Won
   Yeo, Eui Dong
   Lee, Young Koo
   Yang, Seong Seok
TI Evaluation of an Antimicrobial Silver Foam Dressing
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE nanosilver; vacuum-assisted closure; MRSA; rat
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; NANOPARTICLES; MANAGEMENT
AB CuraVAC Ag, a product that delivers negative pressure wound therapy through a polyurethane foam dressing, contains silver nanoparticles, which, when moistened with water, release silver ions onto a wound surface. The in vitro antimicrobial action of silver can destroy both gram-positive and gram-negative bacteria, as well as methicillin-resistant Staphylococcus aureus (MRSA). The purpose of this study was to assess the efficacy and in vivo outcomes of using the product. Methods. Thirty-six female Sprague-Dawley white rats, 8-weeks old and 250 g - 300 g in weight, were used. The experimental product was prepared using a vacuum-assisted closure (VAC) kit and coating it using the silver nanoparticles. For the control group, a 10% povidone-iodine solution was applied. Results. All groups showed decreases in wound area over time, in the order CuraVAC Ag (group A) > CuraVAC (group B) > control (group C). On the third, fifth, and seventh days, wound healing efficacy scores increased in both group A and group C. Groups A and B showed more rapid decreases than group C in bacterial culture from wounds. Conclusion. CuraVAC Ag may be useful for treatment of wounds infected with bacteria.
C1 [Park, Jun Kyu] CG Bio Co Ltd, Kyonggi Do, South Korea.
   [Lee, Jong Hoon] Eulji Univ, Sch Med, Eulji Gen Hosp, Dept Plast & Reconstruct Surg, Seoul, South Korea.
   [Kwak, Jeong Ja] Soonchunhyang Univ, Dept Pathol, Gyeonggi Do, South Korea.
   [Shin, Hee Bong] Soonchunhyang Univ, Dept Lab Med, Gyeonggi Do, South Korea.
   [Shin, Hee Bong] Soonchunhyang Univ, Dept Genet, Gyeonggi Do, South Korea.
   [Jung, Hae Won] Incheon Saranghosp, Dept Nephrol, Incheon Si, South Korea.
   [Bae, Sang Won] Baroseum Hosp, Dept Orthoped Surg, Daejeon Si, South Korea.
   [Yeo, Eui Dong; Lee, Young Koo] Soonchunhyang Univ, Dept Orthoped Surg, Gyeonggi Do, South Korea.
   [Yang, Seong Seok] Soonchunhyang Univ, Bucheon Hosp, Coll Med, Dept Orthoped Surg, Seoul, South Korea.
C3 Eulji University; Soonchunhyang University; Soonchunhyang University;
   Soonchunhyang University; Soonchunhyang University; Soonchunhyang
   University
RP Lee, YK (通讯作者)，Soonchunhyang Univ, Dept Orthoped Surg, 4 Jung Dong, Bucheon Si 420767, Gyeonggi Do, South Korea.
EM brain0808@hanmail.net
OI Yeo, Euidong/0000-0002-7844-3552
FU Basic Science Research Program through the National Research Foundation
   of Korea; Ministry of Education, Science, and Technology [2011-0013275]
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea, funded by the
   Ministry of Education, Science, and Technology (2011-0013275).
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NR 14
TC 10
Z9 10
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2013
VL 25
IS 6
BP 153
EP 159
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 174LP
UT WOS:000321157300005
PM 25866981
DA 2026-07-24
ER
PT J
AU Daigle, P
   Despatis, MA
   Grenier, G
AF Daigle, Patrick
   Despatis, Marc-Antoine
   Grenier, Guillaume
TI How mechanical deformations contribute to the effectiveness of
   negative-pressure wound therapy
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; MYOFIBROBLAST
   DIFFERENTIATION; EXTRACELLULAR-MATRIX; GRANULATION-TISSUE; TENSION;
   REPAIR; MECHANOTRANSDUCTION; CONTRACTION; HYPOXIA
AB Negative-pressure wound therapy (NPWT) has significantly improved healing rates and patient comfort since its inception. However, a considerable number of questions have been raised regarding its mechanisms of action. Many health care workers and researchers have attempted to clarify the role of NPWT in wound healing. The purpose of this perspective article is to assemble some of the concepts that have been put forward in order to propose an integrated view of the mechanisms involved in NPWT. Particular emphasis will be placed on mechanically induced tissue deformations and their involvement in some of the key processes of wound healing, including nutrient and oxygen transport, blood vessel formation, and cellular proliferation and differentiation, mainly of myofibroblasts.
C1 [Daigle, Patrick; Despatis, Marc-Antoine; Grenier, Guillaume] Univ Sherbrooke, Etienne LeBel Clin Res Ctr, Sherbrooke, PQ J1K 2R1, Canada.
   [Despatis, Marc-Antoine] Univ Sherbrooke, Div Vasc Surg, Dept Surg, Sherbrooke, PQ J1K 2R1, Canada.
   [Grenier, Guillaume] Univ Sherbrooke, Fac Med, Dept Surg, Div Orthopaed Surg, Sherbrooke, PQ, Canada.
C3 University of Sherbrooke; University of Sherbrooke; University of
   Sherbrooke
RP Despatis, MA (通讯作者)，3001-12th Ave North, Sherbrooke, PQ J1H 5N4, Canada.
EM marc-antoine.despatis@usherbrooke.ca; guillaume.grenier@usherbrooke.ca
FU Fonds pour la Recherche en Sante du Quebec (FRSQ); FRSQ; Canadian
   Institutes of Health Research
FX Patrick Daigle holds scholarships from the Fonds pour la Recherche en
   Sante du Quebec (FRSQ). Guillaume Grenier holds an Investigator Award
   from FRSQ. This work was supported by grants from the Canadian
   Institutes of Health Research.
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NR 48
TC 30
Z9 41
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL
PY 2013
VL 21
IS 4
BP 498
EP 502
DI 10.1111/wrr.12052
PG 5
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 174VZ
UT WOS:000321186200003
PM 23627711
DA 2026-07-24
ER
PT J
AU Li, RG
   Ren, GH
   Tan, XJ
   Yu, B
   Hu, JJ
AF Li, Run-guang
   Ren, Gao-hong
   Tan, Xiong-jin
   Yu, Bin
   Hu, Ji-jie
TI Free flap transplantation combined with skin grafting and vacuum sealing
   drainage for repair of circumferential or sub-circumferential
   soft-tissue wounds of the lower leg
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE free flap transplantation; skin grafting; circumferential wounds; vacuum
   sealing drainage (VSD); microsurgical techniques
ID NEGATIVE-PRESSURE THERAPY; ASSISTED CLOSURE; LOWER-EXTREMITY;
   RECONSTRUCTION; MANAGEMENT; COVERAGE; FRACTURES; OUTCOMES; TRAUMA; FLOW
AB Background: This study is aimed at evaluating the operation techniques and clinical significance of free flap transplantation combined with skin grafting and vacuum sealing drainage (VSD) in repairing severe traumatic extensive circumferential or semi-circumferential soft-tissue defects of the lower leg.
   Material/Methods: Thirty patients with severe lower leg injuries were treated by free flap transplantation combined with skin grafting and VSD from January 2008 to June 2011. The size of the wounds ranged from 23 x 8 cm to 44 x 28 cm and all affected more 70% of the low leg circumferential area. Wounds were complicated by exposure, necrosis, or infection of deep tissues. The wounds were first debrided and covered by VSD. When the condition of the wound had improved (5 to 7 days later), free flaps were harvested to reconstruct damaged tissue and skin grafts and VSD was used to cover granulation tissues around the transplanted flap.
   Results: Granulation tissues developed and the area requiring flap cover decreased in all 30 patients after debridement and VSD. In 28 of 30 cases, the transplanted flaps grew well without complication. Peripheral necrosis was observed in only 2 cases, which required a second debridement and skin graft. Ten wound areas covered by grafts were left with scattered peripheral wounds, which healed with the help of 1 more skin graft or dressing change. Morphological appearance and functional recovery were satisfactory in all 30 cases.
   Conclusions: Initial debridement and the temporary VSD cover followed after several days by free flap transplantation combined with skin grafting and VSD protection is a reliable treatment regimen for traumatic large circumferential or sub-circumferential soft tissue wounds of the lower leg with deep tissue exposure.
C1 [Li, Run-guang; Ren, Gao-hong; Yu, Bin; Hu, Ji-jie] Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou, Guangdong, Peoples R China.
   [Tan, Xiong-jin] 169th Hosp PLA, Dept Orthoped, Hengyang, Hunan, Peoples R China.
C3 Southern Medical University - China
RP Ren, GH (通讯作者)，Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou, Guangdong, Peoples R China.
EM doctor020@163.com
OI Gaohong, Ren/0000-0002-4941-6723; Runguang, Li/0000-0002-4703-7180
FU "Natural Science Foundation of Guangdong Province" in China
   [S2012010009434]; "Special Project on the Integration of Industry,
   Education and Research of Guangdong Province" in China [2012B091100462]
FX This work was supported by the "Natural Science Foundation of Guangdong
   Province" (Approval number S2012010009434) and "Special Project on the
   Integration of Industry, Education and Research of Guangdong Province"
   (Approval number 2012B091100462) in China
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NR 40
TC 35
Z9 56
U1 0
U2 23
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JUN 28
PY 2013
VL 19
BP 510
EP 517
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 174WW
UT WOS:000321188800001
PM 23807087
OA hybrid
DA 2026-07-24
ER
PT J
AU Barysch, MJ
   Weibel, L
   Neuhaus, K
   Subotic, U
   Schärer, L
   Donghi, D
   Hafner, J
   Braun, R
   Läuchli, S
   Dummer, R
   Schiestl, C
AF Barysch, Marjam J.
   Weibel, Lisa
   Neuhaus, Kathrin
   Subotic, Ulrike
   Schaerer, Leo
   Donghi, Davide
   Hafner, Juerg
   Braun, Ralph
   Laeuchli, Severin
   Dummer, Reinhard
   Schiestl, Clemens
TI Dermatofibrosarcoma Protuberans in Childhood Treated with Slow Mohs
   Micrographic Surgery
SO PEDIATRIC DERMATOLOGY
LA English
DT Article
ID IMATINIB MESYLATE; EXCISION; CHILDREN
AB Dermatofibrosarcoma protuberans (DFSP) in childhood is a rare tumor with high recurrence rates. Wide local excision can result in disfiguring mutilation, whereas Mohs micrographic surgery (MMS) reduces surgical margins. MMS in children is not performed routinely, as the required infrastructures such as a histopathology lab in close proximity to the operating room is often lacking. We retrospectively reviewed children diagnosed with DFSP treated at our hospital over 2years. We recorded surgical treatment details, including margins, duration of inpatient stay, outcome, follow-up, and molecular genetic tumor tissue analysis. Four children with a median age of 6.8years (range 6.0-8.8years) were identified who had a diagnostic delay of a median of 2.5years (range 0.5-4.0years); all underwent complete tumor excision using the slow MMS technique using vacuum-assisted closure systems between repeated excisions and before wound closure. The median maximal safety margins were 1.5cm (range 1.0-3.0cm). By using vacuum-assisted closure systems, no dressing changes were needed, pain was limited, and full mobility was maintained in all children. The median total time in the hospital was 11days (range 10-14days). No relapses occurred during a median follow-up of 25.8months (range 11.3-32.6months). Collagen 1A1/platelet-derived growth factor B (COL1A1/PDGFB) translocation on chromosomes 17 and 22 was detected in all three analyzable specimens. Lesions suspected of being DFSP warrant prompt histologic evaluation; interdisciplinary management is mandatory in particular for children. Micrographic surgery allows smaller surgical margins than wide excision and should be considered as the treatment of choice in children with DFSP. The interim usage of vacuum-assisted closure systems increases patient comfort. Translocations in the COL1A1/PDGFB gene imply susceptibility to targeted treatment modalities for therapy-resistant cases.
C1 [Barysch, Marjam J.; Neuhaus, Kathrin; Subotic, Ulrike; Schiestl, Clemens] Univ Childrens Hosp Zurich, Dept Plast & Reconstruct Surg, Zurich, Switzerland.
   [Barysch, Marjam J.; Weibel, Lisa; Hafner, Juerg; Braun, Ralph; Laeuchli, Severin; Dummer, Reinhard] Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland.
   [Barysch, Marjam J.; Weibel, Lisa; Neuhaus, Kathrin; Subotic, Ulrike; Schiestl, Clemens] Childrens Res Ctr, Zurich, Switzerland.
   [Weibel, Lisa] Univ Childrens Hosp Zurich, Zurich, Switzerland.
   [Schaerer, Leo] Inst Dermatopathol, Friedrichshafen, Germany.
C3 University Children's Hospital Zurich; University of Zurich; University
   Zurich Hospital; University Children's Hospital Zurich
RP Schiestl, C (通讯作者)，Univ Childrens Hosp Zurich, Dept Surg, Zurich, Switzerland.
EM clemens.schiestl@kispi.uzh.ch
RI ; Dummer, Reinhard/JQI-5867-2023
OI Subotic, Ulrike/0000-0002-1383-1036; Braun, Ralph P/0000-0003-1253-8206;
   Weibel, Lisa/0000-0002-8696-8164; Neuhaus, Kathrin/0000-0003-2438-1779
CR Chang CK, 2004, EJSO, V30, P341, DOI 10.1016/j.ejso.2003.12.005
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NR 25
TC 12
Z9 15
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-8046
EI 1525-1470
J9 PEDIATR DERMATOL
JI Pediatr. Dermatol.
PD JUL
PY 2013
VL 30
IS 4
BP 462
EP 468
DI 10.1111/pde.12039
PG 7
WC Dermatology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Pediatrics
GA 175CC
UT WOS:000321206100024
PM 23432099
OA Bronze
DA 2026-07-24
ER
PT J
AU Yang, YH
   Jeng, SF
   Hsieh, CH
   Feng, GM
   Chen, CC
AF Yang, Yi-Hsun
   Jeng, Seng-Feng
   Hsieh, Ching-Hua
   Feng, Guan-Ming
   Chen, Chien Chung
TI Vacuum-assisted closure for complicated wounds in head and neck region
   after reconstruction
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Vacuum-assisted closure (VAC) system; Negative pressure wound therapy
   (NPWT); Head and neck reconstruction; Complicated wound; Fistula
   formation
ID TOPICAL NEGATIVE-PRESSURE; FAILED FREE FLAPS; TRAUMATIC WOUNDS; VAC(R)
   THERAPY; MANAGEMENT; SURGERY; SYSTEM; EXPERIENCE; EXTREMITY; DRESSINGS
AB Objective: The aim of this study is to suggest that negative pressure wound therapy (NPWT) is an excellent alternative for managing complicated wounds after head and neck reconstruction.
   Summary background data: Management of complicated wounds such as wound infection or persistent saliva leakage from poor wound healing with dead space is challenging in head and neck reconstruction. The NPWT is a useful device widely used in treating many complicated wounds. In this study, we applied this device on complicated wounds after head and neck reconstruction and share our experience and modifications.
   Methods: From January 2004 to December 2009, 13 male patients (mean age: 50.0 years) were included. Eleven patients were reconstructed with free flap transfer and the other two patients received a local flap for repair immediately after tumour ablation. Among them, 12 patients (92%) had complicated wounds with infection and one patient (8%) with partial loss of the free flap. Eight of these 13 patients (62%) had saliva leakage and fistula formation. For those who had a free flap transfer, the vacuum-assisted closure (VAC) system was applied with modifications to the complicated wound 2 weeks later, after better neo-vascularisation around the free flap. Watertight suturing on the mucosal side is needed to ensure air sealing and enhance wound healing acquired by the VAC system.
   Results: All wounds demonstrated adequate control of wound infection, quick obliteration of dead space and rapid growth of granulation tissue under the NPWT. Eleven patients (85%) had wound healing with secondary intention; one (8%) needed a further skin grafting; and one patient (8%) needed a free flap transfer due to partial flap loss in a severe wound infection even after the NPWT application. The average duration of the NPWT usage was 10.8 days (4-24 days); most of the wounds healed within 1 week after the NPWT application.
   Conclusion: The NPWT is an excellent alternative for managing complicated wounds after head and neck reconstruction. It is safe and comfortable for the patient and provides good results in infection control, dead space obliteration and improvement of wound healing. (c) 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Yang, Yi-Hsun; Jeng, Seng-Feng; Feng, Guan-Ming; Chen, Chien Chung] I Shou Univ, E Da Hosp, Dept Plast & Reconstruct Surg, Kaohsiung, Taiwan.
   [Hsieh, Ching-Hua] Chang Gung Univ, Dept Plast & Reconstruct Surg, Kaohsiung Chang Gung Mem Hosp, Tao Yuan, Taiwan.
   [Hsieh, Ching-Hua] Coll Med, Tao Yuan, Taiwan.
C3 E-Da Hospital; I Shou University; Chang Gung Memorial Hospital; Chang
   Gung University
RP Chen, CC (通讯作者)，I Shou Univ, E Da Hosp, Dept Plast & Reconstruct Surg, Kaohsiung, Taiwan.
EM rason0709@hotmail.com
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NR 31
TC 35
Z9 48
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2013
VL 66
IS 8
BP E209
EP E216
DI 10.1016/j.bjps.2013.03.006
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 178IM
UT WOS:000321441300001
PM 23578735
DA 2026-07-24
ER
PT J
AU Carey, JN
   Sheckter, CC
   Watt, AJ
   Lee, GK
AF Carey, Joseph N.
   Sheckter, Clifford C.
   Watt, Andrew J.
   Lee, Gordon K.
TI Intra-abdominal pedicled rectus abdominis muscle flap for treatment of
   high-output enterocutaneous fistulae: Case reports and review of
   literature
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Enterocutaneous fistula; Pedicled flap; Rectus abdominis
ID SURGICAL REPAIR; CLOSURE; ABDOMEN
AB Despite advances in nutritional supplementation, sepsis management, percutaneous drainage and surgical technique, enterocutaneous fistulae remain a considerable source of morbidity and mortality. Use of adjunctive modalities including negative pressure wound therapy and fibrin glue have been shown to improve the rapidity of fistula closure; however, the overall rate of closure remains poor. The challenge of managing chronic, high-output proximal enterocutaneous fistulae can be successfully achieved with appropriate medical management and intra-abdominal placement of pedicled rectus abdominis muscle flaps. We report two cases of recalcitrant high output enterocutaneous fistulae that were treated successfully with pedicled intra-abdominal rectus muscle flaps. Indications for pedicled intra-abdominal rectus muscle flaps include persistent patency despite a reasonable trial of non-operative intervention, failure of traditional operative interventions (serosal patch, Graham patch), and persistent electrolyte and nutritional abnormalities in the setting of a high-output fistula. (C) 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Carey, Joseph N.; Sheckter, Clifford C.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
   [Watt, Andrew J.; Lee, Gordon K.] Stanford Univ, Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Stanford, CA 94305 USA.
C3 University of Southern California; Stanford University
RP Lee, GK (通讯作者)，Stanford Univ, Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Stanford, CA 94305 USA.
EM glee@stanford.edu
CR Chander J, 2004, WORLD J SURG, V28, P179, DOI 10.1007/s00268-003-7017-5
   Chang SH, 2010, J PLAST RECONSTR AES, V63, P1055, DOI 10.1016/j.bjps.2009.10.024
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   Scala M, 2012, PLAST RECONSTR SURG, V129, p391E, DOI 10.1097/PRS.0b013e31823af180
NR 10
TC 8
Z9 9
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2013
VL 66
IS 8
BP 1145
EP 1148
DI 10.1016/j.bjps.2012.12.008
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 178IM
UT WOS:000321441300026
PM 23317765
DA 2026-07-24
ER
PT J
AU Hasse, B
   Husmann, L
   Zinkernagel, A
   Weber, R
   Lachat, M
   Mayer, D
AF Hasse, Barbara
   Husmann, Lars
   Zinkernagel, Annelies
   Weber, Rainer
   Lachat, Mario
   Mayer, Dieter
TI Vascular graft infections
SO SWISS MEDICAL WEEKLY
LA English
DT Article
DE prosthetic vascular graft infection; negative pressure wound therapy;
   graft preservation; 18F-fluorodeoxyglucose positron emission tomography;
   computed tomographic angiography
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAP COVERAGE; ANTIMICROBIAL THERAPY;
   PROSTHESIS INFECTION; F-18-FDG PET/CT; DACRON GRAFTS; WOUND CLOSURE;
   MANAGEMENT; SURGERY; COMPLICATIONS
AB Vascular procedures are rarely complicated by infection, but if prosthetic vascular graft infection (PVGI) occurs, morbidity and mortality are high. Several patient-related, surgery-related and postoperative risk factors are reported, but they are not well validated. PVGI is due to bacterial colonisation of the wound and the underlying prosthetic graft, generally as a result of direct contamination during the operative procedure, mainly from the patient's skin or adjacent bowel. There is no consensus on diagnostic criteria or on the best management of PVGI. On the basis of reported clinical studies and our own experience, we advocate a surgical approach combining repeated radical local debridement, with graft preservation whenever possible or partial excision of the infected graft, depending on its condition, plus simultaneous negative-pressure wound therapy (NPWT). In addition, antimicrobial therapy is recommended, but there is no consensus on which classes of agent are adequate for the treatment of PVGI and whether certain infections may be treated by means of NPWT alone. Since staphylococci and Gram-negative rods are likely to be isolated, empirical treatment might include a penicillinase-resistant beta-lactam or a glycopeptide, plus an aminoglycoside, the latter for Gram-negative coverage and synergistic treatment of Gram-positive cocci. Additionally, empirical treatment might include rifampicin since it penetrates well into biofilms.
C1 [Hasse, Barbara; Zinkernagel, Annelies; Weber, Rainer] Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, CH-8091 Zurich, Switzerland.
   [Hasse, Barbara; Husmann, Lars; Zinkernagel, Annelies; Weber, Rainer; Lachat, Mario; Mayer, Dieter] Univ Zurich, CH-8091 Zurich, Switzerland.
   [Husmann, Lars] Univ Zurich Hosp, Clin Nucl Med, CH-8091 Zurich, Switzerland.
   [Lachat, Mario; Mayer, Dieter] Univ Zurich Hosp, Cardiovasc Surg Clin, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP Hasse, B (通讯作者)，Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Raemistr 100, CH-8091 Zurich, Switzerland.
EM barbara.hasse@usz.ch; dieter.mayer@usz.ch
RI Lachat, Mario/G-4826-2011; Zinkernagel, Annelies/F-1780-2017; Weber,
   Rainer/D-5175-2012; Mayer, Dieter/E-7617-2011; Hasse,
   Barbara/T-1054-2017
OI Lachat, Mario/0000-0001-7812-2110; Zinkernagel,
   Annelies/0000-0003-4700-1118; Mayer, Dieter/0000-0001-5933-7749; Hasse,
   Barbara/0000-0001-7196-3734
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NR 51
TC 91
Z9 98
U1 0
U2 5
PU E M H SWISS MEDICAL PUBLISHERS LTD
PI MUTTENZ
PA FARNSBURGERSTR 8, CH-4132 MUTTENZ, SWITZERLAND
SN 1424-7860
EI 1424-3997
J9 SWISS MED WKLY
JI Swiss Med. Wkly.
PD JAN 24
PY 2013
VL 143
AR w13754
DI 10.4414/smw.2013.13754
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 184QH
UT WOS:000321907400001
PM 23348860
OA Green Submitted, Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Acosta, S
   Monsen, C
   Dencker, M
AF Acosta, Stefan
   Monsen, Christina
   Dencker, Magnus
TI Clinical outcome and microvascular blood flow in VAC®- and
   Sorbalgon®-treated peri-vascular infected wounds in the groin
   after vascular surgery - an early interim analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Groin infection; Laser Doppler blood flow; Negative pressure wound
   therapy; Vacuum-assisted wound closure; Vascular surgery
ID ASSISTED CLOSURE THERAPY; GRAFT INFECTIONS
AB Vacuum-assisted wound closure (VAC (R)) therapy is considered to be superior to conventional dressings in the treatment of peri-vascular groin infections after vascular surgery at our department. Therefore, we performed an early interim analysis of the clinical outcomes in these seriously ill patients at risk of amputation and death. Patients were randomised to either VAC (R) (n = 5) or Sorbalgon (R) (n = 5; best alternative treatment) therapy after surgical debridement. Non-invasive, laser Doppler perfusion imaging (LDPI) studies of the skin adjacent to the undressed wound were performed after 14 days of wound treatment. There was no difference in LDPI values in VAC (R) versus Sorbalgon (R) treated patients (P = 0 center dot 46). One patient in the VAC (R) group suffered from two re-bleeding episodes, leading to vascular resection and transfemoral amputation and in the Sorbalgon (R) group two had a complete wound healing time of more than 4 months and one had a visible interposition bypass graft in the groin after 1 month of treatment. No patient died of the groin infection. Although not statistically proven, fewer wound treatment failures were recorded in the VAC (R) group, justifying this early interim analysis. LDPI studies were feasible.
C1 [Acosta, Stefan; Monsen, Christina] Malmo Univ Hosp, Vasc Ctr Malmo Lund, SE-20502 Malmo, Sweden.
   [Dencker, Magnus] Skane Univ Hosp, Dept Clin Physiol & Nucl Med, Malmo, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Acosta, S (通讯作者)，Malmo Univ Hosp, Vasc Ctr Malmo Lund, SE-20502 Malmo, Sweden.
EM stefan.acosta@telia.com
RI Acosta, Stefan/JAX-3225-2023; Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-8895-6001; Acosta, Stefan/0000-0002-3225-0798
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NR 13
TC 14
Z9 16
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2013
VL 10
IS 4
BP 377
EP 382
DI 10.1111/j.1742-481X.2012.00993.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 187YM
UT WOS:000322157600006
PM 22672773
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Young, SR
   Hampton, S
   Martin, R
AF Young, Stephen R.
   Hampton, Sylvie
   Martin, Robin
TI Non-invasive assessment of negative pressure wound therapy using high
   frequency diagnostic ultrasound: oedema reduction and new tissue
   accumulation
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Granulation tissue; High frequency diagnostic ultrasound;
   Macrodeformation; Negative pressure wound therapy; Tissue oedema
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; GAUZE; SKIN
AB Tissue oedema plays an important role in the pathology of chronic and traumatic wounds. Negative pressure wound therapy (NPWT) is thought to contribute to active oedema reduction, yet few studies have showed this effect. In this study, high frequency diagnostic ultrasound at 20 MHz with an axial resolution of 60 mu m was used to assess the effect of NPWT at - 80 mmHg on pressure ulcers and the surrounding tissue. Wounds were monitored in four patients over a 3-month period during which changes in oedema and wound bed thickness (granulation tissue) were measured non-invasively. The results showed a rapid reduction of periwound tissue oedema in all patients with levels falling by a mean of 43% after 4 days of therapy. A 20% increase in the thickness of the wound bed was observed after 7 days due to new granulation tissue formation. Ultrasound scans through the in situ gauze NPWT filler also revealed the existence of macrodeformation in the tissue produced by the negative pressure. These preliminary studies suggest that non-invasive assessment using high frequency diagnostic ultrasound could be a valuable tool in clinical studies of NPWT.
C1 [Young, Stephen R.] Skin Sci Consultancy, Cambridge, England.
   [Hampton, Sylvie] Tissue Viabil Consultancy Serv, Eastbourne, England.
   [Martin, Robin] Smith & Nephew Med Ltd, Adv Wound Devices Strateg Business Unit, Kingston Upon Hull HU3 2BN, N Humberside, England.
C3 Smith & Nephew
RP Martin, R (通讯作者)，Smith & Nephew Med Ltd, Adv Wound Devices Strateg Business Unit, POB 81,101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM robin.martin@smith-nephew.com
OI Martin, Robin/0000-0002-9314-0437
FU Smith and Nephew
FX The study was funded by Smith and Nephew. RM is an employee of Smith and
   Nephew.
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NR 28
TC 24
Z9 28
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2013
VL 10
IS 4
BP 383
EP 388
DI 10.1111/j.1742-481X.2012.00994.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 187YM
UT WOS:000322157600007
PM 22672782
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Zhao, JC
   Xian, CJ
   Yu, JA
   Shi, K
AF Zhao Jing-Chun
   Xian Chun-Jing
   Yu Jia-Ao
   Shi Kai
TI Reconstruction of infected and denuded scrotum and penis by combined
   application of negative pressure wound therapy and split-thickness skin
   grafting
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Genital defects; Negative pressure wound therapy; Reconstruction;
   Split-thickness skin graft
ID GANGRENE
AB Trauma to the genital region and perineum can leave behind lifelong sequelae and pose significant challenges to surgeons in the restoration of functional ability and aesthetic status. Effective methods and techniques are indispensable during the treatment period. Negative pressure wound therapy (NPWT) is a widely accepted technique that is becoming a commonplace treatment in many clinical settings. The purpose of this case report was to introduce the efficacy of the concurrent usage of NPWT and split-thickness skin grafting (STSG) in the reconstruction of genital injuries. A man suffered a traffic accident that caused necrosis of the scrotum and penis associated with a severe infection caused by Pseudomonas aeruginosa and Enterobacter cloacea. After debridement, we adopted NPWT during the postoperative dressing changes and the application of meshed STSG. The outcomes showed that combination of NPWT and split-thickness skin grafts is safe, well-tolerated and efficient in the reconstruction of penoscrotal defects. This could be a versatile tool for reconstruction after perineal and penoscrotal trauma.
C1 [Zhao Jing-Chun; Xian Chun-Jing; Yu Jia-Ao; Shi Kai] Jilin Univ, Hosp 1, Burns & Plast Reconstruct Unit, Changchun 130031, Jilin Province, Peoples R China.
C3 Jilin University
RP Yu, JA (通讯作者)，Jilin Univ, Hosp 1, Burns & Plast Reconstruct Unit, 3302 Jilin Rd, Changchun 130031, Jilin Province, Peoples R China.
EM bu_dong007@163.com
CR Aydin T, 2010, J PLAST RECONSTR AES, V63, P1394, DOI 10.1016/j.bjps.2010.01.006
   Borgquist O, 2011, OSTOMY WOUND MANAG, V57, P44
   Dunn R, 2011, INT J SURG, V9, P258, DOI 10.1016/j.ijsu.2010.12.005
   Jing-Chun Z, 2011, WOUNDS, V23, pe21
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   Maguiña P, 2003, BURNS, V29, P857, DOI 10.1016/j.burns.2003.07.001
   Maguina P, 2010, PLAST RECONSTR SURG, V125, p28E, DOI 10.1097/PRS.0b013e3181c2a292
   Pham C, 2007, BURNS, V33, P946, DOI 10.1016/j.burns.2007.03.020
   Rapp DE, 2005, UROLOGY, V65, P1216, DOI 10.1016/j.urology.2005.02.006
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   Wang DL, 2003, BRIT J PLAST SURG, V56, P484, DOI 10.1016/S0007-1226(03)00187-5
NR 14
TC 16
Z9 16
U1 0
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2013
VL 10
IS 4
BP 407
EP 410
DI 10.1111/j.1742-481X.2012.00997.x
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 187YM
UT WOS:000322157600010
PM 22672131
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Hlebowicz, J
AF Lindstedt, Sandra
   Hlebowicz, Joanna
TI Blood flow response in small intestinal loops at different depths during
   negative pressure wound therapy of the open abdomen
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Intestinal wall; Microvascular blood flow; Negative pressure wound
   therapy; Open abdomen
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; INTRAABDOMINAL
   HYPERTENSION; ENTEROCUTANEOUS FISTULA; PROTECTIVE DISC; MANAGEMENT;
   LAPAROSTOMY; WALL; RECOMMENDATIONS; SEPSIS
AB High closure rates of the open abdomen have been reported following negative pressure wound therapy (NPWT). However, the method has occasionally been associated with increased development of intestinal fistulae. We have previously shown that the application of NPWT to the open abdomen causes a decrease in microvascular blood flow in the small intestinal loop and the omentum adjacent to the visceral protective layer of the dressing. In this study we investigate whether the negative pressure affects only small intestinal loops lying directly below the dressing or if it also affects small intestinal loops that are not in direct contact with the dressing. Six pigs underwent midline incision and application of NPWT to the open abdomen. The microvascular blood flow was measured in four intestinal loops at different depths from the visceral protective layer, at two different locations: beneath the dressing and at the anterior abdominal wall, before and after the application of NPWT of -50, -70, -100, -120, -150 and -170 mmHg, using laser Doppler velocimetry. Negative pressures between -50 and -170 mmHg caused a significant decrease in the microvascular blood flow in the intestinal loops in direct contact with the visceral protective layer. A slight, but significant, decrease in blood flow was also seen in the intestinal loops lying beneath these loops. The decrease in microvascular blood flow increased with the amount of negative pressure applied. No difference in blood flow was seen in the intestinal loops lying deeper in the abdominal cavity. A decrease in blood flow was seen in the upper two intestinal loops located apically and anteriorly, but not in the lower two, indicating that this is a local effect and that pressure decreases with distance from the source. A long-term decrease in blood flow in the intestinal wall may induce ischaemia and secondary necrosis in the intestinal wall, which could promote the development of intestinal fistulae. We believe that NPWT of the open abdomen is a very effective treatment, but that it could be improved by gaining more knowledge on the mechanisms involved.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Dept Cardiothorac Surg, S-21112 Lund, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, Malmo, Sweden.
C3 Lund University; Skane University Hospital; Lund University
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, S-21112 Lund, Sweden.
EM sandra.lindstedt.ingemansson@gmail.com
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473
FU Region Skane
FX We would like to thank our funding source Region Skane.
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Amin AI, 2009, WORLD J GASTROENTERO, V15, P3394, DOI 10.3748/wjg.15.3394
   Becker HP, 2007, SCAND J SURG, V96, P263, DOI 10.1177/145749690709600402
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   Cheatham ML, 2010, CRIT CARE MED, V38, P402, DOI 10.1097/CCM.0b013e3181b9e9b1
   Cheatham ML, 2009, WORLD J SURG, V33, P1116, DOI 10.1007/s00268-009-0003-9
   Deenichin GP, 2008, SURG TODAY, V38, P5, DOI 10.1007/s00595-007-3573-x
   DeFranzo AJ, 2006, CLIN PLAST SURG, V33, P213, DOI 10.1016/j.cps.2005.12.007
   Draus JM, 2006, SURGERY, V140, P570, DOI 10.1016/j.surg.2006.07.003
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   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   Schachtrupp A, 2002, Hernia, V6, P155
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   ZOGRAFOS GC, 1992, ANN SURG, V215, P266, DOI 10.1097/00000658-199203000-00011
NR 32
TC 5
Z9 6
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2013
VL 10
IS 4
BP 411
EP 417
DI 10.1111/j.1742-481X.2012.00998.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 187YM
UT WOS:000322157600011
PM 22698003
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Gabriel, A
   Thimmappa, B
   Rubano, C
   Storm-Dickerson, T
AF Gabriel, Allen
   Thimmappa, Brinda
   Rubano, Christopher
   Storm-Dickerson, Toni
TI Evaluation of an ultra-lightweight, single-patient-use negative pressure
   wound therapy system over dermal regeneration template and skin grafts
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Dermal regeneration template; Skin graft; Ultra-lightweight negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; CONTROLLED-TRIAL;
   RECONSTRUCTION; INTEGRA; DEVICE; FOOT
AB As the use of negative pressure wound therapy (NPWT) over skin grafts has increased, traditional methods of NPWT system reimbursement and application are increasingly being challenged. A simplified method of accessing and operating NPWT in the outpatient setting is needed, particularly in cases where immediate outpatient use of NPWT is optimal. We evaluated use of a new ultra-lightweight, off-the-shelf, disposable, single-patient-use NPWT system (SP-NPWT; V.A.C.Via Therapy, KCI USA, Inc., San Antonio, TX) over dermal regeneration template (DRT) and/or skin grafts. SP-NPWT was initiated over a DRT and/or skin graft in 33 patients with 41 graft procedures. Endpoints were recorded and compared to a historical control group of 25 patients with 28 grafts bolstered with traditional rental NPWT (V.A.C.(R) Therapy, KCI USA, Inc.). Average length of inpatient hospital stay was 0 center dot 0 days for the SP-NPWT group and 6 center dot 0 days for the control group (P < 0 center dot 0001). The average duration of SP-NPWT post-DRT or skin graft was 5 center dot 6 days for the SP-NPWT group and 7 center dot 0 days for the control (P < 0 center dot 0001). Preliminary data suggest that, compared to traditional NPWT, off-the-shelf SP-NPWT may provide a quicker, seamless transition to home, resulting in decreased hospital stay and potential cost savings.
C1 [Gabriel, Allen; Thimmappa, Brinda; Rubano, Christopher; Storm-Dickerson, Toni] Southwest Washington Med Ctr, Dept Surg, Vancouver, WA 98664 USA.
RP Gabriel, A (通讯作者)，Southwest Washington Med Ctr, Dept Surg, 505 NE 87th Ave Bldg A Suite 250, Vancouver, WA 98664 USA.
EM gabrielallen@yahoo.com
RI Gabriel, Allen/AFK-3548-2022
CR Avery C, 2000, INT J ORAL MAX SURG, V29, P198, DOI 10.1016/S0901-5027(00)80092-2
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Blume PA, 2010, INT WOUND J, V7, P480, DOI 10.1111/j.1742-481X.2010.00728.x
   *CMS H, 2005, MEDCAC M US CAR CHRO
   *CMS H, 2009, ROADM QUAL MEAS TRAD
   GABRIEL A, 2011, 2011 CLIN S ADV SKIN
   Grant I, 2001, BURNS, V27, P699, DOI 10.1016/S0305-4179(01)00040-7
   Jencks SF, 2009, NEW ENGL J MED, V360, P1418, DOI 10.1056/NEJMsa0803563
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
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NR 16
TC 8
Z9 8
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2013
VL 10
IS 4
BP 418
EP 424
DI 10.1111/j.1742-481X.2012.00999.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 187YM
UT WOS:000322157600012
PM 22682307
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Omran, N
   Habal, P
   Mandak, J
   Chek, JL
AF Omran, Nedal
   Habal, Petr
   Mandak, Jiri
   Chek, James L.
TI Broncho-Pleural Fistula Following Vacuum-Assisted Closure Therapy
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
AB Wereport a case of bronchopleural- cutaneous fistula following long-term vacuum-assisted closure therapy to manage a sternal dehiscence after coronary artery bypass surgery.
C1 Charles Univ Prague, Fac Med, Dept Cardiac Surg, Hradec Kralove, Czech Republic.
   Charles Univ Prague, Fac Hosp Hradec Kralove, Dept Cardiac Surg, Hradec Kralove, Czech Republic.
C3 University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague
RP Omran, N (通讯作者)，Charles Univ Hosp, Dept Cardiac Surg, Sokolska 581, Hradec Kralove 50005, Czech Republic.
EM nidal81@gmail.com
RI /AAK-7375-2021; Chek, James Lago/E-4971-2018; Habal, Petr/O-3068-2017;
   Manďák, Jiří/H-5767-2016
OI Chek, James Lago/0000-0001-9957-5071; Habal, Petr/0000-0002-7338-0185;
   Manďák, Jiří/0000-0003-3673-0534
FU research programme PRVOUK [P-37/04]
FX The work was supported by the research programme PRVOUK P-37/04
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Kiessling AH, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-16
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Petzina R, 2006, EUR J CARDIO-THORAC, V30, P85, DOI 10.1016/j.ejcts.2006.04.009
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   TAVILLA G, 1991, ANN THORAC SURG, V52, P1179, DOI 10.1016/0003-4975(91)91310-R
NR 7
TC 5
Z9 6
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD JUL
PY 2013
VL 28
IS 4
BP 397
EP 398
DI 10.1111/jocs.12126
PG 2
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 188BR
UT WOS:000322167100016
PM 23711339
DA 2026-07-24
ER
PT J
AU Tavusbay, C
   Kar, H
   Cin, N
   Kamer, E
   Aksut, H
   Karahalli, O
   Atahan, K
   Haciyanli, M
AF Tavusbay, Cengiz
   Kar, Haldun
   Cin, Necat
   Kamer, Erdinc
   Aksut, Hayri
   Karahalli, Onder
   Atahan, Kemal
   Haciyanli, Mehmet
TI The use of vacuum-assisted wound closure system for management of
   difficult wounds.
SO BIOMEDICAL RESEARCH-INDIA
LA English
DT Article
DE Fournier's gangrene; Open abdomen; wound dehiscence; Vacuum assisted
   closure therapy
ID ABDOMINAL WOUNDS; SUBATMOSPHERIC PRESSURE; CLINICAL-EXPERIENCE; THERAPY;
   FISTULAS; STATE
AB We aimed to present the results of our different clinical practise experience about the treatment and management of extremely difficult wounds using the vacuum-assisted closure system (VAC). In this retrospective study, we analysed the records of 51 consecutive patients who were applied VAC for different clinical practise between 2008 and 2012 at the Izmir Katip Celebi University, Ataturk Education and Training Hospital. There were 51 patients in our study with an average age of 54.6(16-78) years and 22(43.1%) were male, and 29(56.9%) were females. We used VAC system to manage the wound in 29(56.9%) patients with wound dehiscence (with or without fascial necrosis), in 17(33.3%) patients with open abdomen, and in 5(9.8%) patients with Fournier gangrene. The average hospital stay was38.4 days (10-101). The average duration of VAC application was 24.3 (8-56) days. The average number the application of VAC dressingswas 12.01 (3 to 28). Directly VAC related complications (enteroatmospheric fistula and wound haematoma) were seen in two patients (3.9%). A total of 27(52.9%) patients underwent delayed primary or graft closure. In the remaining 19(37.2%) patients, the wound was left to granulate and heal by secondary intention. 5 (9.8%) patients died because of complications related to primary disease while on VAC application. We concluded that VAC is an important tool in the armamentarium of the surgeons managing in patients with complex and difficult wounds, particularly, in cases of open abdomen.
C1 [Tavusbay, Cengiz; Kar, Haldun; Cin, Necat; Kamer, Erdinc; Aksut, Hayri; Karahalli, Onder; Atahan, Kemal; Haciyanli, Mehmet] Izmir Katip Celebi Univ, Ataturk Res & Training Hosp, TR-35360 Izmir, Turkey.
C3 Izmir Katip Celebi University; Izmir Ataturk Training & Research
   Hospital
RP Tavusbay, C (通讯作者)，Erzene Mah Sehit Taha Carim Cad Ozveri Sitesi 3-1, TR-35050 Izmir, Turkey.
RI TAVUSBAY, Cengiz/N-9236-2014; kar, haldun/R-6845-2019; HACIYANLI,
   MEHMET/P-6709-2019; Kamer, Erdinc/A-5245-2009
OI Kamer, Erdinc/0000-0002-5084-5867
CR [Anonymous], EUR J TRAUMA
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   BanwellP E., 2004, INT WOUND J, V1, P95
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NR 22
TC 1
Z9 2
U1 0
U2 1
PU SCIENTIFIC PUBLISHERS INDIA
PI ALIGARH
PA 87-GREATER AZAD ENCLAVE, P O QUARSI, ALIGARH, 00000, INDIA
SN 0970-938X
J9 BIOMED RES-INDIA
JI Biomed. Res.-India
PD JUL-SEP
PY 2013
VL 24
IS 3
BP 329
EP 336
PG 8
WC Engineering, Biomedical; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Research & Experimental Medicine
GA 189ZZ
UT WOS:000322308100008
DA 2026-07-24
ER
PT J
AU Deng, K
   Yu, AX
   Xia, CY
   Li, ZH
   Wang, WY
AF Deng, Kai
   Yu, Ai-Xi
   Xia, Cheng-Yan
   Li, Zong-Huan
   Wang, Wei-Yang
TI Combination of negative pressure wound therapy with open bone grafting
   for bone and soft tissue defects
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE negative pressure wound therapy; bone graft; osseous/soft tissue defect;
   polluted wound
AB The aim of this study was to investigate the efficiency of negative pressure wound therapy (NPWT) combined with open bone graft (OBG; NPWT-OBG) for the treatment of bone and soft tissue defects with polluted wounds in an animal model. All rabbits with bone and soft tissue defects and polluted wounds were randomly divided into two groups, the experimental group (NPWT with bone graft) and the control group (OBG). The efficacy of the treatment was assessed by the wound conditions and healing time. Bacterial bioburdens and bony calluses were evaluated by bacteria counting and X-rays, respectively. Furthermore, granulation tissue samples from the wounds on days 0, 3, 7 and 14 of healing were evaluated for blood vessels and vascular endothelial growth factor (VEGF) levels. Wounds in the experimental group tended to have a shorter healing time, healthier wound conditions, lower bacterial bioburden, improvement of the bony calluses and an increased blood supply compared with those in the control group. With NPWT, wound infection was effectively controlled. For wounds with osseous and soft tissue defects, NPWT combined with bone grafting was demonstrated to be more effective than an OBG.
C1 [Deng, Kai; Yu, Ai-Xi; Xia, Cheng-Yan; Li, Zong-Huan; Wang, Wei-Yang] Wuhan Univ, Dept Microorthoped, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Dept Microorthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM yuaixi666@163.com
FU National Natural Science Funds of China [81171713]; National Natural
   Science Funds of Hubei Province [2012FFB04311]
FX This project was supported by the National Natural Science Funds of
   China (grant no. 81171713) and the National Natural Science Funds of
   Hubei Province (grant no. 2012FFB04311).
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NR 21
TC 12
Z9 14
U1 0
U2 10
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD AUG
PY 2013
VL 8
IS 2
BP 468
EP 472
DI 10.3892/mmr.2013.1536
PG 5
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 190XS
UT WOS:000322377400025
PM 23784004
OA Bronze
DA 2026-07-24
ER
PT J
AU Walter, G
   Kemmerer, M
   Hoffmann, R
AF Walter, G.
   Kemmerer, M.
   Hoffmann, R.
TI Treatment of Septic Olecranon and Patellar Bursitis by Excision and
   Vacuum-Assisted Closure Therapy
SO ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
LA German
DT Article
DE septic olecranon bursitis; septic patellar bursitis; total bursectomy
ID ANTIBIOTIC-THERAPY; PREPATELLAR; DIAGNOSIS
AB Background: Treatment of septic olecranon and patellar bursitis differs considerably and is currently under discussion. We therefore performed a retrospective study of our patients with septic bursitis in the past 5 years.
   Patients and Method: Between March 2007 and February 2012 we treated 79 patients with septic olecranon (n = 43) and patellar (n = 36) bursitis surgically: 61-males, 18 females, age 51 (range: 11-91) years. Four patients had not been treated before, 25 had suffered recurrences after 1-10 previous procedures, and 9 patients had not improved after conservative therapy. 34 patients presented with traumatic rupture or fistula of their bursae. In all cases we performed a radical bursectomy and vacuum-assisted therapy for 4 to 5 days. In addition, patients received systemic antibiotics. We phoned all patients and were successful in 57 cases (72%). We questioned these patients for range of movement, limitations at work, pain, sensibility disorder, satisfaction with the result and further surgical procedures. In all cases we took tissue specimens for cultures, in 48 preparations histological examination was performed.
   Results: Microbiological and histological results are discussed in detail. 40 patients were free of complaints, 15 complained of mild pain, 54 of 57 had unlimited range of motion. Minor discomforts at desk work were reported by 5 of 43 patients, 12 out of 36 patient reported discomfort when performing on their knees. There was no recurrence in the period of investigation.
   Conclusion: We recommend our treatment concept for septic olecranon and patellar bursitis because patient satisfaction is high and recurrences are reliably avoided. The soft tissue is spared, so that plastic covering procedures are seldom necessary.
C1 [Walter, G.; Kemmerer, M.] Berufsgenossenschaftliche Unfallklin, Friedberger Landstr 430, D-60389 Frankfurt, Germany.
RP Walter, G (通讯作者)，Berufsgenossenschaftliche Unfallklin, Friedberger Landstr 430, D-60389 Frankfurt, Germany.
EM gerhard.walter@bgu-frankfurt.de
CR Abzug JM, 2012, J HAND SURG-AM, V37A, P1252, DOI 10.1016/j.jhsa.2011.08.036
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NR 18
TC 2
Z9 3
U1 0
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1864-6697
EI 1864-6743
J9 Z ORTHOP UNFALLCHIR
JI Z. Orthop. Unfallchir.
PD AUG
PY 2013
VL 151
IS 4
BP 353
EP 357
DI 10.1055/s-0033-1350612
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 203RS
UT WOS:000323311400005
PM 23963983
DA 2026-07-24
ER
PT J
AU Valesky, EM
   Kaufmann, R
   Meissner, M
AF Valesky, E. M.
   Kaufmann, R.
   Meissner, M.
TI Special indications for negative pressure wound therapy in dermatologic
   surgery
SO HAUTARZT
LA German
DT Article
DE Vacuum sealing; Hidradenitis suppurativa; Trepanation; Split skin graft;
   Wounds
ID VACUUM-ASSISTED CLOSURE; CLOSED INCISION MANAGEMENT; THICKNESS
   SKIN-GRAFTS; EXPRESSION; FLUID
AB In recent years negative pressure wound therapy (NPWT) has gained more and more supporters in dermatologic surgery. NPWT has become one of the standard therapeutic options, especially for non-healing diabetic, venous and arterial ulcers of the legs. When managing large wounds after tumor surgery, NPWT is frequently used to induce granulation tissue and reduce wound size before the wound is closed with split- or full-thickness skin grafts or local flaps. In addition to these well-established uses, NPWT can be also employed for a variety of "new" or rare indications, some of which are presented in this review.
C1 [Valesky, E. M.; Kaufmann, R.; Meissner, M.] Univ Frankfurt Klinikum, Klin Dermatol Venerol & Allergol, D-60590 Frankfurt, Germany.
C3 Goethe University Frankfurt; Goethe University Frankfurt Hospital
RP Valesky, EM (通讯作者)，Univ Frankfurt Klinikum, Klin Dermatol Venerol & Allergol, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
EM eva.valesky@kgu.de
RI Meissner, Markus/F-9125-2014
OI Meissner, Markus/0000-0002-5630-587X
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NR 29
TC 4
Z9 6
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0017-8470
EI 1432-1173
J9 HAUTARZT
JI Hautarzt
PD AUG
PY 2013
VL 64
IS 8
BP 585
EP 591
DI 10.1007/s00105-013-2545-x
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 204DY
UT WOS:000323346500006
PM 23896694
DA 2026-07-24
ER
PT J
AU Cheatham, ML
   Demetriades, D
   Fabian, TC
   Kaplan, MJ
   Miles, WS
   Schreiber, MA
   Holcomb, JB
   Bochicchio, G
   Sarani, B
   Rotondo, MF
AF Cheatham, Michael L.
   Demetriades, Demetrios
   Fabian, Timothy C.
   Kaplan, Mark J.
   Miles, William S.
   Schreiber, Martin A.
   Holcomb, John B.
   Bochicchio, Grant
   Sarani, Babak
   Rotondo, Michael F.
TI Prospective Study Examining Clinical Outcomes Associated with a Negative
   Pressure Wound Therapy System and Barker's Vacuum Packing Technique
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION;
   INTERNATIONAL-CONFERENCE; AMERICAN-ASSOCIATION; OPEN ABDOMEN; CLOSURE;
   MANAGEMENT; TRAUMA; COMPLICATION; SURGERY
AB The open abdomen has become a common procedure in the management of complex abdominal problems and has improved patient survival. The method of temporary abdominal closure (TAC) may play a role in patient outcome.
   A prospective, observational, open-label study was performed to evaluate two TAC techniques in surgical and trauma patients requiring open abdomen management: Barker's vacuum-packing technique (BVPT) and the ABThera(TM) open abdomen negative pressure therapy system (NPWT). Study endpoints were days to and rate of 30-day primary fascial closure (PFC) and 30-day all-cause mortality.
   Altogether, 280 patients were enrolled from 20 study sites. Among them, 168 patients underwent at least 48 hours of consistent TAC therapy (111 NPWT, 57 BVPT). The two study groups were well matched demographically. Median days to PFC were 9 days for NPWT versus 12 days for BVPT (p = 0.12). The 30-day PFC rate was 69 % for NPWT and 51 % for BVPT (p = 0.03). The 30-day all-cause mortality was 14 % for NPWT and 30 % for BVPT (p = 0.01). Multivariate logistic regression analysis identified that patients treated with NPWT were significantly more likely to survive than the BVPT patients [odds ratio 3.17 (95 % confidence interval 1.22-8.26); p = 0.02] after controlling for age, severity of illness, and cumulative fluid administration.
   Active NPWT is associated with significantly higher 30-day PFC rates and lower 30-day all-cause mortality among patients who require an open abdomen for at least 48 h during treatment for critical illness.
C1 [Cheatham, Michael L.] Orlando Reg Med Ctr Inc, Dept Surg Educ, Orlando, FL 32806 USA.
   [Demetriades, Demetrios] Los Angeles Cty Univ Southern Calif Med Ctr, Los Angeles, CA USA.
   [Fabian, Timothy C.] Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA.
   [Kaplan, Mark J.] Albert Einstein Med Ctr, Philadelphia, PA 19141 USA.
   [Miles, William S.] Carolinas Med Ctr, Charlotte, NC 28203 USA.
   [Schreiber, Martin A.] Oregon Hlth & Sci Univ, Portland, OR USA.
   [Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
   [Bochicchio, Grant] Univ Maryland, Baltimore, MD 21201 USA.
   [Sarani, Babak] Univ Penn, Pittsburgh, PA USA.
   [Rotondo, Michael F.] E Carolina Univ, Greenville, NC USA.
C3 Orlando Health; Orlando Regional Medical Center; University of Tennessee
   System; University of Tennessee Health Science Center; Yeshiva
   University; Carolinas Medical Center; Oregon Health & Science
   University; University of Texas System; University of Texas Health
   Science Center Houston; University System of Maryland; University of
   Maryland Baltimore; University of Pennsylvania; University of North
   Carolina; East Carolina University
RP Cheatham, ML (通讯作者)，Orlando Reg Med Ctr Inc, Dept Surg Educ, 86 West Underwood St,Suite 201, Orlando, FL 32806 USA.
EM michael.cheatham@orlandohealth.com
RI ; Martin, Schreiber/F-2175-2013
OI holcomb, john/0000-0001-8312-9157; Sarani, Babak/0000-0001-6247-3004; 
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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NR 27
TC 131
Z9 159
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD SEP
PY 2013
VL 37
IS 9
BP 2018
EP 2030
DI 10.1007/s00268-013-2080-z
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 204MM
UT WOS:000323369400002
PM 23674252
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hasegawa, K
   Namba, Y
   Kimata, Y
AF Hasegawa, Kenjiro
   Namba, Yuzaburo
   Kimata, Yoshihiro
TI Negative Pressure Wound Therapy Incorporating Early Exercise Therapy in
   Hand Surgery: Bag-type Negative Pressure Wound Therapy
SO ACTA MEDICA OKAYAMA
LA English
DT Article
DE negative pressure wound therapy; early exercise therapy; wound healing;
   hand surgery
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; CLINICAL-EXPERIENCE;
   INJURIES
AB In the postoperative treatment of hand surgery, it is important to start exercise therapy as early as possible. In conventional negative pressure wound therapy, the fingers are immobilized by the film dressing covering the wound and hand, thereby preventing sufficient rehabilitation. Here, we devised a bag-type negative pressure wound therapy that makes it possible to start finger exercises almost immediately, and we applied it to 4 patients: one each with hand burns, symmetrical peripheral gangrene, a crush injury accompanied by extensive skin defects and a fingertip degloving injury. The duration of the bag-type negative pressure wound therapy ranged from three to eight weeks, and good granulation was achieved, so that a skin graft was not required. In addition, particularly in the case of the fingertip degloving injury, good nail regeneration was achieved. Except for the case of symmetrical peripheral gangrene, a good range of joint motion with a percent total active motion (% TAM) of 94.7% or more was achieved. Our therapy was performed by inserting the hand into a sealing bag; sufficient exercise therapy was made possible by expanding the bag during rehabilitation.
C1 [Hasegawa, Kenjiro; Namba, Yuzaburo; Kimata, Yoshihiro] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Plast & Reconstruct Surg, Okayama 7008558, Japan.
C3 Okayama University
RP Hasegawa, K (通讯作者)，Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Plast & Reconstruct Surg, Okayama 7008558, Japan.
EM k-hase@md.okayama-u.ac.jp
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   Ng R, 2006, J PLAST RECONSTR AES, V59, P1011, DOI 10.1016/j.bjps.2006.02.002
   Shimizu T, 2012, INJURY, V43, P940, DOI 10.1016/j.injury.2012.02.011
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NR 18
TC 10
Z9 12
U1 0
U2 5
PU OKAYAMA UNIV MED SCHOOL
PI OKAYAMA
PA EDITORIAL OFFICE, ACTA MEDICA OKAYAMA OKAYAMA UNIVERSITY MEDICAL SCHOOL
   2-5-1 SHIKATA-CHO, KITA-KU, OKAYAMA, 700-8558, JAPAN
SN 0386-300X
J9 ACTA MED OKAYAMA
JI Acta Med. Okayama
PD AUG
PY 2013
VL 67
IS 4
BP 271
EP 276
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 205UK
UT WOS:000323470100010
PM 23970327
DA 2026-07-24
ER
PT J
AU Morinaga, K
   Kiyokawa, K
   Rikimaru, H
   Aoyagi, S
   Tayama, K
   Akashi, H
AF Morinaga, Keigo
   Kiyokawa, Kensuke
   Rikimaru, Hideaki
   Aoyagi, Shigeaki
   Tayama, Keiichiro
   Akashi, Hidetoshi
TI Results of intra-wound continuous negative pressure irrigation treatment
   for mediastinitis
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Mediastinitis; wound healing; wound closure; exposed heart and aorta;
   artificial dermis
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; POSTSTERNOTOMY
   MEDIASTINITIS; CARDIAC-SURGERY; INFECTION; EXPERIENCE; DRAINAGE;
   COMPLICATIONS; MANAGEMENT; MORTALITY
AB Intra-wound continuous negative pressure irrigation treatment (IW-CONPIT) was administered to cases of mediastinitis as the therapy of choice, with satisfactory results being obtained in terms of improved survival rates and quick healing of wounds. Accordingly, these treatment results and efficacy were evaluated. After debridement, a sponge was trimmed to conform to the shape of the wound and then it was attached to the surface of the wound. Two tubes with several side holes were placed within the sponge. In cases in which the blood vessels and/or the heart are exposed, an artificial dermis was attached to cover the blood vessels and/or the heart in order to not come in direct contact with the sponge. Next, the top of the wound was covered with polyethylene film to create an air-tight wound seal. A bottle of saline solution was connected to one of the tubes and a continuous aspirator to the other, and continuous negative pressure irrigation of the wound was thus carried out. After performing this treatment for 2-3 weeks, and when wound granulation improved, either skin grafts or the transplantation of muscle flaps was performed as necessary to achieve wound healing. A combination of the continuous negative pressure method and the continuous irrigation method resulted in improved healing rates and lower mortality rates for mediastinitis. It also significantly reduced the number of dressings, as well as the degree of labour and medical materials required; therefore, a reduced hospital stay and shorter treatment period was thus achieved using this treatment method.
C1 [Morinaga, Keigo; Kiyokawa, Kensuke; Rikimaru, Hideaki] Kurume Univ, Sch Med, Dept Plast & Reconstruct Surg & Maxillofacial Sur, Kurume, Fukuoka 8300011, Japan.
   [Aoyagi, Shigeaki; Tayama, Keiichiro; Akashi, Hidetoshi] Kurume Univ, Sch Med, Dept Surg, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University
RP Morinaga, K (通讯作者)，Kurume Univ, Sch Med, Dept Plast & Reconstruct Surg & Maxillofacial Sur, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM prsmf@med.kurume-u.ac.jp
RI Kiyokawa, Kensuke/Q-5559-2017
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   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 20
TC 9
Z9 11
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD SEP
PY 2013
VL 47
IS 4
BP 297
EP 302
DI 10.3109/2000656X.2013.765885
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 206AY
UT WOS:000323489200013
PM 23710790
OA gold
DA 2026-07-24
ER
PT J
AU Rentea, RM
   Somers, KK
   Cassidy, L
   Enters, J
   Arca, MJ
AF Rentea, Rebecca M.
   Somers, Kimberly K.
   Cassidy, Laura
   Enters, Jessica
   Arca, Marjorie J.
TI Negative pressure wound therapy in infants and children: a
   single-institution experience
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Wound healing; Neonatal; Infants; Abdominal wounds; Negative pressure
   wound therapy; Surgery
ID VACUUM-ASSISTED CLOSURE; PEDIATRIC-PATIENTS; MANAGEMENT; GASTROSCHISIS;
   MEDIASTINITIS; FRACTURES; INFECTION; INJURIES; SURGERY; SKIN
AB Background: Information regarding the use of negative pressure wound therapy (NPWT) in the pediatric population is limited. Because of adverse outcomes in adult patients, the Food and Drug Administration issued a warning in 2011 about the use of NPWT in infants and children.
   Methods: We performed an institutional review board-approved, single-institution, retrospective review of pediatric patients who had undergone NPWT from 2007-2011. We collected the types of wounds for which NPWT was initiated, the NPWT outcomes, and the complications encountered.
   Results: The data from 290 consecutive patients were reviewed. Their average age was 9.3 y (range 12 d to 18 y), and their average weight was 46.5 kg (range 1.1-177). Of the wounds, 66% were classified as acute, 10% as chronic, and 24% as traumatic. The two most common indications were surgical wound dehiscence (n = 47) and skin grafting (n = 41). NPWT was used in 15 wounds containing surgical hardware, with 2 devices requiring eventual removal. NPWT was used for a median of 9 d per patient (two dressing changes). Complications occurred in 5 patients (1.7%). Documentation problems were noted in 44 patients. After NPWT, about one-third of the patients (n = 95 patients) were able to undergo delayed primary closure.
   Conclusions: NPWT is an effective adjunct in wound healing and closure in the pediatric population, with no mortality ascribed to NPWT. Also, the complication rates were low. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Rentea, Rebecca M.] Med Coll Wisconsin, Dept Surg, Milwaukee, WI 53226 USA.
   [Somers, Kimberly K.; Cassidy, Laura; Enters, Jessica; Arca, Marjorie J.] Med Coll Wisconsin, Childrens Hosp Wisconsin, Dept Surg, Div Pediat Surg, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin; Medical College of Wisconsin; Children's
   Hospital of Wisconsin
RP Arca, MJ (通讯作者)，Med Coll Wisconsin, Childrens Hosp Wisconsin, Dept Surg, Div Pediat Surg, 999 North 92nd Ave,Suite 320, Milwaukee, WI 53226 USA.
EM marca@chw.org
OI Rentea, Rebecca/0000-0002-8689-5989
CR American Academy of Pediatrics, US DRUGS NOT DESCR P
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NR 27
TC 29
Z9 34
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
J9 J SURG RES
JI J. Surg. Res.
PD SEP
PY 2013
VL 184
IS 1
BP 658
EP 664
DI 10.1016/j.jss.2013.05.056
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 207NX
UT WOS:000323609400106
PM 23768766
DA 2026-07-24
ER
PT J
AU Cheong, YK
   Jun, H
   Cho, YP
   Song, GW
   Moon, KM
   Kwon, TW
   Lee, SG
AF Cheong, Yong-Kyu
   Jun, Heungman
   Cho, Yong-Pil
   Song, Gi-Won
   Moon, Ki-Myung
   Kwon, Tae-Won
   Lee, Sung-Gyu
TI Negative pressure wound therapy for inguinal lymphatic complications in
   critically ill patients
SO JOURNAL OF THE KOREAN SURGICAL SOCIETY
LA English
DT Article
DE Wound; Lymphatic; Complication; Negative pressure; Therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Purpose: In this study, we investigated the therapeutic potential of regulated negative pressure vacuum-assisted wound therapy for inguinal lymphatic complications in critically ill, liver transplant recipients.
   Methods: The great saphenous vein was harvested for hepatic vein reconstruction during liver transplantation in 599 living-donor liver transplant recipients. Fourteen of the recipients (2.3%) developed postoperative inguinal lymphatic complications and were treated with negative pressure wound therapy, and they were included in this study.
   Results: The average total duration of negative pressure wound therapy was 23 days (range, 11 to 42 days). Complete resolution of the lymphatic complications and wound healing were achieved in all 14 patients, 5 of whom were treated in hospital and 9 as outpatients. There was no clinically detectable infection, bleeding or recurrence after an average follow-up of 27 months (range, 7 to 36 months).
   Conclusion: Negative pressure wound therapy is an effective, readily-available treatment option that is less invasive than exploration and ligation of leaking lymphatics and provides good control of drainage and rapid wound closure in critically ill patients.
C1 [Cheong, Yong-Kyu; Cho, Yong-Pil; Song, Gi-Won; Kwon, Tae-Won; Lee, Sung-Gyu] Univ Ulsan, Dept Surg, Asan Med Ctr, Coll Med, Seoul 138736, South Korea.
   [Jun, Heungman] Korea Univ, Dept Surg, Anam Hosp, Seoul, South Korea.
   [Moon, Ki-Myung] Pusan Natl Univ, Dept Surg, Yangsan Hosp, Yangsan, South Korea.
C3 University of Ulsan; Asan Medical Center; Korea University; Korea
   University Medicine (KU Medicine); Pusan National University; Pusan
   National University Hospital
RP Cho, YP (通讯作者)，Univ Ulsan, Dept Surg, Asan Med Ctr, Coll Med, 88 Olymp Ro 43 Gil, Seoul 138736, South Korea.
EM ypcho@amc.seoul.kr
RI Jun, Heungman/AFN-9427-2022
FU Daewoong Pharma Group
FX This work was supported in part by the Daewoong Pharma Group.
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NR 22
TC 1
Z9 2
U1 0
U2 2
PU KOREAN SURGICAL SOCIETY
PI SEOUL
PA 3304HO, 101 DONG, BROWNSTONE SEOUL, 335, JUNGMIN-DONG, JUNG-GU, SEOUL,
   100-859, SOUTH KOREA
SN 2233-7903
EI 2093-0488
J9 J KOREAN SURG SOC
JI J. Korean Surg. Soc.
PD SEP
PY 2013
VL 85
IS 3
BP 134
EP 138
DI 10.4174/jkss.2013.85.3.134
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 210AP
UT WOS:000323802000007
PM 24020023
OA gold
DA 2026-07-24
ER
PT J
AU Yusuf, E
   Jordan, X
   Clauss, M
   Borens, O
   Mäder, M
   Trampuz, A
AF Yusuf, Erlangga
   Jordan, Xavier
   Clauss, Martin
   Borens, Olivier
   Maeder, Mark
   Trampuz, Andrej
TI High bacterial load in negative pressure wound therapy (NPWT) foams used
   in the treatment of chronic wounds
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BREAST IMPLANTS; JOINT INFECTION; SONICATION;
   DIAGNOSIS; CONTAMINATION; TRIAL
AB No earlier study has investigated the microbiology of negative pressure wound therapy (NPWT) foam using a standardized manner. The purpose of this study is to investigate the bacterial load and microbiological dynamics in NPWT foam removed from chronic wounds (>3 months). To determine the bacterial load, a standardized size of the removed NPWT foam was sonicated. The resulting sonication fluid was cultured, and the colony-forming units (CFU) of each species were enumerated. Sixty-eight foams from 17 patients (mean age 63 years, 71% males) were investigated. In 65 (97%) foams, 1 and in 37 (54%) 2 bacterial types were found. The bacterial load remained high during NPWT treatment, ranging from 10(4) to 10(6) CFU/ml. In three patients (27%), additional type of bacteria was found in subsequent foam cultures. The mean bacterial count +/- standard deviation was higher in polyvinyl alcohol foam (6.1 +/- 0.5 CFU/ml) than in polyurethane (5.5 +/- 0.8 CFU/ml) (p=0.02). The mean of log of sum of CFU/ml in foam from 125mmHg (5.5 +/- 0.8) was lower than in foam from 100mmHg pressure (5.9 +/- 0.5) (p=0.01). Concluding, bacterial load remains high in NPWT foam, and routine changing does not reduce the load.
C1 [Yusuf, Erlangga; Borens, Olivier] Univ Lausanne Hosp, Surg Sept Unit, Dept Surg & Anesthesiol, Lausanne, Switzerland.
   [Jordan, Xavier; Maeder, Mark] Ctr Paraplegia & Craniocerebral Injury REHAB, Basel, Switzerland.
   [Clauss, Martin] Kantonsspital Baselland, Clin Orthoped & Trauma Surg, Liestal, Switzerland.
   [Trampuz, Andrej] Free & Humboldt Univ Berlin, Charite Univ Med, Ctr Musculoskeletal Surg, D-10117 Berlin, Germany.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Kantonsspital Baselland; Free University of Berlin; Humboldt University
   of Berlin; Charite Universitatsmedizin Berlin
RP Trampuz, A (通讯作者)，Free & Humboldt Univ Berlin, Charite Univ Med, Ctr Musculoskeletal Surg, Charitepl 1, D-10117 Berlin, Germany.
EM andrej.trampuz@gmail.com
RI Trampuz, Andrej/K-9633-2013; Clauss, Martin/K-9981-2019; Yusuf,
   Erlangga/H-5166-2019
OI Clauss, Martin/0000-0002-1598-2209; Yusuf, Erlangga/0000-0003-4779-2191;
   Jordan, Xavier/0000-0003-3389-0057
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NR 24
TC 58
Z9 67
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2013
VL 21
IS 5
BP 677
EP 681
DI 10.1111/wrr.12088
PG 5
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 210IQ
UT WOS:000323825300005
PM 23927079
DA 2026-07-24
ER
PT J
AU Wiegand, C
   Springer, S
   Abel, M
   Wesarg, F
   Ruth, P
   Hipler, UC
AF Wiegand, Cornelia
   Springer, Steffen
   Abel, Martin
   Wesarg, Falko
   Ruth, Peter
   Hipler, Uta-Christina
TI Application of a drainage film reduces fibroblast ingrowth into
   large-pored polyurethane foam during negative-pressure wound therapy in
   an in vitro model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID ASSISTED CLOSURE THERAPY; GAUZE; TRANSDUCTION; EXPRESSION; DEVICE; SKIN
AB Negative-pressure wound therapy (NPWT) is an advantageous treatment option in wound management to promote healing and reduce the risk of complications. NPWT is mainly carried out using open-cell polyurethane (PU) foams that stimulate granulation tissue formation. However, growth of wound bed tissue into foam material, leading to disruption of newly formed tissue upon dressing removal, has been observed. Consequently, it would be of clinical interest to preserve the positive effects of open-cell PU foams while avoiding cellular ingrowth. The study presented analyzed effects of NPWT using large-pored PU foam, fine-pored PU foam, and the combination of large-pored foam with drainage film on human dermal fibroblasts grown in a collagen matrix. The results showed no difference between the dressings in stimulating cellular migration during NPWT. However, when NPWT was applied using a large-pored PU foam, the fibroblasts continued to migrate into the dressing. This led to significant breaches in the cell layers upon removal of the samples after vacuum treatment. In contrast, cell migration stopped at the collagen matrix edge when fine-pored PU foam was used, as well as with the combination of PU foam and drainage film. In conclusion, placing a drainage film between collagen matrix and the large-pored PU foam dressing reduced the ingrowth of cells into the foam significantly. Moreover, positive effects on cellular migration were not affected, and the effect of the foam on tissue surface roughness in vitro was also reduced.
C1 [Wiegand, Cornelia; Springer, Steffen; Hipler, Uta-Christina] Univ Med Ctr Jena, Dept Dermatol, D-07740 Jena, Germany.
   [Wesarg, Falko] Univ Jena, Inst Mat Sci & Technol, Jena, Germany.
   [Abel, Martin; Ruth, Peter] Lohmann & Rauscher GmbH & Co KG, Rengsdorf, Germany.
C3 Friedrich Schiller University of Jena; Lohmann & Rauscher (L&R)
RP Wiegand, C (通讯作者)，Univ Med Ctr Jena, Dept Dermatol, Erfurter Str 35, D-07740 Jena, Germany.
EM c.wiegand@med.uni-jena.de
RI ; Abel, Martin/JFS-2478-2023
OI Springer, Steffen/0000-0002-9224-2925; Abel, Martin/0000-0002-0683-0553
FU Lohmann & Rauscher GmbH & Co KG, Rengsdorf, Germany; Lohmann & Rauscher
   GmbH Co. KG Germany
FX This work was funded by Lohmann & Rauscher GmbH & Co KG, Rengsdorf,
   Germany.The authors would like to disclose that the authors M. A. and P.
   R. are employees of Lohmann & Rauscher GmbH & Co. KG Germany and that
   the authors C. W. and U.-C. H. received travel grants from Lohmann &
   Rauscher GmbH & Co. KG Germany to participate at wound healing
   conferences.
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NR 25
TC 4
Z9 5
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2013
VL 21
IS 5
BP 697
EP 703
DI 10.1111/wrr.12073
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 210IQ
UT WOS:000323825300008
PM 23937617
DA 2026-07-24
ER
PT J
AU Davis, KE
   Lafontaine, J
   Bills, J
   Noble, D
   Wight-Carter, M
   Oni, G
   Rohrich, RJ
   Lavery, LA
AF Davis, Kathryn E.
   Lafontaine, Javier
   Bills, Jessica
   Noble, Deborah
   Wight-Carter, Mary
   Oni, Georgette
   Rohrich, Rod J.
   Lavery, Lawrence A.
TI The comparison of two negative-pressure wound therapy systems in a
   porcine model of wound healing
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; GAUZE
AB The purpose of this study was to compare two negative-pressure wound healing systems (NPWT), -75mmHg with a silicone-coated (SC) dressing and -125mmHg with polyurethane foam dressing (standard of care). In addition, this study compared the effects of two different dressing interfaces, SC dressing and gauze, with -75mmHg pressure. For both comparisons, two groups of five pigs were evaluated over a 21-day time course. Two excisional wounds were made on each animal and NPWT dressings were applied. A canvas saddle was constructed to hold the NPWT device so the animal had free range of the pen. Dressings were changed twice a week and wound measurements were taken. Specimens for histology and gene expression analyses were taken on day 7 and 21. These data show that there is increased expression in a few genes associated with remodeling and inflammatory processes in the NPWT-125 with polyurethane foam as compared with the NPWT-75 with SC dressing. These two systems, however, are equivalent with respect to wound healing, histology, and gene expression over 21 days of healing. Further, we demonstrate that there is no difference in measure of healing between the SC dressing and a basic gauze dressing.
C1 [Davis, Kathryn E.; Lafontaine, Javier; Bills, Jessica; Noble, Deborah; Wight-Carter, Mary; Oni, Georgette; Rohrich, Rod J.; Lavery, Lawrence A.] Univ Texas SW Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center
RP Davis, KE (通讯作者)，Univ Texas SW Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd F4-310A, Dallas, TX 75390 USA.
EM kathryn.davis@utsouthwestern.edu
RI rohrich, rod/AAJ-7504-2020
OI Lavery, Lawrence/0000-0002-7920-9952
FU Convatec, Inc.; KCI; Osirus; Health Point; Thermotek; Integra; Glasko
   Smith and Kline; Convatec; Innovative Therapies Inc.
FX This research was funded through an educational grant from Convatec,
   Inc.Dr. Lavery has research grants from KCI, Osirus, Health Point,
   Thermotek, Integra, Glasko Smith and Kline, Convatec, and Innovative
   Therapies Inc. He is on the Speaker's Bureau for Shire, KCI, and
   Innovative Technologies Inc. He is a Consultant/ Advisor for Innovative
   Therapies Inc, Pam Labs. He has Stock ownership in Diabetica Solutions
   and Prizm Medical and holds patents with Diabetica Solutions. Dr. Davis
   has grants from Convatec and Innovative Therapies, Inc.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
NR 22
TC 6
Z9 8
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2013
VL 21
IS 5
BP 740
EP 745
DI 10.1111/wrr.12079
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 210IQ
UT WOS:000323825300013
PM 23926906
OA Bronze
DA 2026-07-24
ER
PT J
AU Fussey, JM
   Luesley, DM
   Sterne, GD
AF Fussey, Jonathan M.
   Luesley, David M.
   Sterne, Guy D.
TI Vaginoplasty: A Modern Approach A Report of 2 Cases
SO JOURNAL OF REPRODUCTIVE MEDICINE
LA English
DT Article
DE fibrin tissue sealant; grafting; skin; plastic surgery; split-thickness
   skin graft; surgical procedure; reconstructive; vacuum-assisted closure;
   vaginoplasty
AB BACKGROUND: Split-thickness skin graft vaginoplasty is one of many methods for vaginal reconstruction. In its 130-year history it has been modified by numerous authors in attempts to improve graft viability and neovaginal function. We describe a modern approach that aims to improve outcomes and reduce complications.
   CASES: Two cases of split-thickness skin graft vaginoplasty are presented in which the traditional Abbe-McIndoe technique was supplemented by the combined use of vacuum-assisted closure and fibrin tissue sealant. In both cases 100% graft survival and normal neovaginal function were observed, with no recipient site complications. Both patients mobilized on postoperative day 3, and both were sexually active 4 months postoperatively.
   CONCLUSION: This approach has not been described previously in the literature. The impressive results seen in these cases suggest that the use of vacuum-assisted closure and fibrin tissue sealant in combination may improve graft survival and resulting neovaginal function.
C1 City Hosp, Dept Gynecol, Birmingham B18 7QH, W Midlands, England.
   [Fussey, Jonathan M.] City Hosp, Dept Plast Surg, Birmingham B18 7QH, W Midlands, England.
C3 University of Birmingham; University of Birmingham
RP Fussey, JM (通讯作者)，City Hosp, Dept Plast Surg, Dudley Rd, Birmingham B18 7QH, W Midlands, England.
EM jfussey@doctors.org.uk
OI Fussey, Jonathan/0000-0001-9971-4334
CR Abbe R., 1898, Med. Rec, V54, P836
   Banister J B, 1938, Proc R Soc Med, V31, P1055
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   Tercan M, 2002, PLAST RECONSTR SURG, V109, P706, DOI 10.1097/00006534-200202000-00044
   Vedung Sigfrid, 1993, Journal of Burn Care and Rehabilitation, V14, P356, DOI 10.1097/00004630-199305000-00009
NR 6
TC 5
Z9 5
U1 0
U2 2
PU SCI PRINTERS & PUBL INC
PI ST LOUIS
PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA
SN 0024-7758
J9 J REPROD MED
JI J. Reprod. Med.
PD SEP-OCT
PY 2013
VL 58
IS 9-10
BP 441
EP 444
PG 4
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 210UF
UT WOS:000323859500013
PM 24050035
DA 2026-07-24
ER
PT J
AU Fagerdahl, AM
   Boström, L
   Ottosson, C
   Ulfvarson, J
AF Fagerdahl, Ann-Mari
   Bostrom, Lennart
   Ottosson, Carin
   Ulfvarson, Johanna
TI Patients' Experience of Advanced Wound Treatment-A Qualitative Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE advanced moist wound therapy; negative pressure wound therapy;
   qualitative research; quality of life; wound treatment
ID LEG ULCERS; GREEN FOAM; BLACK FOAM; OF-LIFE; THERAPY; GAUZE
AB Introduction. Each patient experiences wound treatment differently, and it is important to enhance the knowledge of the impact of the treatment to be able to individualize patient care. Methods. This descriptive qualitative study aims to describe the experience of patients with wounds treated with advanced moist wound therapy (AMWT) and negative pressure wound therapy (NPWT). Data were collected from 15 diaries written by patients during their treatment, and analyzed with content analysis. Results. The results identified an overall theme of "threat to normality," and 3 subcategories including "impact on daily life," "manageability," and "powerlessness." Conclusion. While there were many similarities in the descriptions of the patients in the 2 groups, there also were unique features for each treatment group. For patients treated with AMWT, the main concern was pain. For patients treated with NPWT, the main concern was the optimal functioning of the machine. Patients undergoing wound treatment have different focuses, concerns, and needs related to treatment modality. It is important for health care personnel to carry this in mind to be able to individualize patient care.
C1 [Fagerdahl, Ann-Mari; Bostrom, Lennart] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Surg, S-11883 Stockholm, Sweden.
   [Ottosson, Carin] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Orthopaed Surg, S-11883 Stockholm, Sweden.
   [Ulfvarson, Johanna] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Nursing, S-11883 Stockholm, Sweden.
C3 Sodersjukhuset Hospital; Karolinska Institutet; Karolinska Institutet;
   Sodersjukhuset Hospital; Karolinska Institutet
RP Fagerdahl, AM (通讯作者)，Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden.
EM ann-mari.fagerdahl@sodersjukhuset.se
OI Fagerdahl, Ami/0000-0002-9170-581X
CR Abbotts Joanne, 2010, Br J Nurs, V19, pS37
   Bowers Kate, 2009, Nurs Stand, V24, P47
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NR 22
TC 13
Z9 14
U1 0
U2 13
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2013
VL 25
IS 8
BP 205
EP 211
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Surgery
GA 212WW
UT WOS:000324014500004
PM 25867129
DA 2026-07-24
ER
PT J
AU Reiter, M
   Harréus, U
AF Reiter, Maximilian
   Harreus, Ulrich
TI Vacuum assisted closure in the management of wound healing disorders in
   the head and neck: A retrospective analysis of 23 cases
SO AMERICAN JOURNAL OF OTOLARYNGOLOGY
LA English
DT Article
ID SKIN-GRAFTS; THERAPY; DEVICE
AB Background: Since the middle of the 1990s vacuum-assisted closure (VAC) has been used in many areas of surgery to manage complex wounds and impaired wound healing. Until recently, little attention has been paid to this treatment modality in the field of head and neck surgery. The evaluation of its efficacy in wound healing disorders of the head and neck was the aim of this study.
   Material and methods: Patients with complex wounds and impaired healing treated with VAC therapy between 2008 and 2011 were included into the study. VAC dressings were changed every 3 days and improvements in wound healing were documented.
   Results: 23 patients were treated with VAC therapy, in 18 cases (78%) closure of the defect could be reached without any further surgical procedure. 5 patients needed subsequent regional flap reconstruction to close the remaining defect. All of these patients had undergone salvage surgery in a previously irradiated neck before.
   Conclusion: Vacuum assisted closure is an effective treatment in the management of wound healing disorders and complex wounds in the head and neck. It offers a useful, non-invasive modality to close even large defects in the area. Previous irradiation seems to have a significant negative influence on the outcome of the therapy, but more data are required to assess these effects. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Reiter, Maximilian; Harreus, Ulrich] Univ Munich, Dept Otolaryngol Head & Neck Surg, D-81377 Munich, Germany.
C3 University of Munich
RP Reiter, M (通讯作者)，Univ Munich, Dept Otorhinolaryngol Head & Neck Surg, Grosshadem Clin, Marchioninistr 15, D-81377 Munich, Germany.
EM maximilian.reiter@med.uni-muenchen.de
OI Reiter, Maximilian/0000-0003-3100-6838
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NR 27
TC 20
Z9 25
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0196-0709
EI 1532-818X
J9 AM J OTOLARYNG
JI Am. J. Otolaryngol.
PD SEP-OCT
PY 2013
VL 34
IS 5
BP 411
EP 415
DI 10.1016/j.amjoto.2013.03.001
PG 5
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 214QC
UT WOS:000324149400009
PM 23558358
DA 2026-07-24
ER
PT J
AU Spillebeen, AL
   Or, M
   Van Goethem, B
   de Rooster, H
AF Spillebeen, A. L.
   Or, M.
   Van Goethem, B.
   de Rooster, H.
TI Negative pressure wound therapy to promote wound healing in companion
   animals
SO VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
LA Dutch
DT Review
ID VACUUM-ASSISTED-CLOSURE; SUBATMOSPHERIC PRESSURE; MANAGEMENT; SKIN;
   OSTEOMYELITIS; TRIAL; EXPERIENCE; ULCERS
AB Negative pressure wound therapy is a respected treatment method in human patients with acute and chronic wounds. The local application of negative pressure stimulates the blood flow and the formation of healthy granulation tissue, and also evacuates exudate. Worldwide, there is a growing interest in the application of negative pressure wound therapy in companion animals. Promising results have been reported although more research is necessary to study the effects of this treatment in dogs and cats. A thorough evaluation of the applicability and the advantages of negative pressure wound therapy in companion animals is recommended.
C1 [Spillebeen, A. L.; Or, M.; Van Goethem, B.; de Rooster, H.] Univ Ghent, Vakgrp Geneeskunde & Klin Biol Kleine Huisdieren, Fac Diergeneeskunde, Salisburylaan 133, B-9820 Merelbeke, Belgium.
C3 Ghent University
RP Spillebeen, AL (通讯作者)，Univ Ghent, Vakgrp Geneeskunde & Klin Biol Kleine Huisdieren, Fac Diergeneeskunde, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM A.L.Spillebeen@uu.nl
RI de Rooster, Hilde/AAX-9497-2020; Van Goethem, Bart/AAM-7175-2020
OI de Rooster, Hilde/0000-0001-8087-256X; 
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NR 70
TC 3
Z9 3
U1 1
U2 10
PU UNIV GHENT
PI GHENT
PA FACULTY VETERINARY MEDICINE, B-9000 GHENT, BELGIUM
SN 0303-9021
J9 VLAAMS DIERGEN TIJDS
JI Vlaams Diergeneeskd. Tijdschr.
PD JUL-AUG
PY 2013
VL 82
IS 4
BP 191
EP 200
DI 10.21825/vdt.v82i4.16696
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 216LH
UT WOS:000324284400003
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hansen, E
   Durinka, JB
   Costanzo, JA
   Austin, MS
   Deirmengian, GK
AF Hansen, Erik
   Durinka, Joel B.
   Costanzo, James A.
   Austin, Matthew S.
   Deirmengian, Gregory K.
TI Negative Pressure Wound Therapy Is Associated With Resolution of
   Incisional Drainage in Most Wounds After Hip Arthroplasty
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
ID TOTAL KNEE ARTHROPLASTY; CLOSED SURGICAL INCISIONS; ASSISTED CLOSURE
   DEVICE; MANAGEMENT; INFECTION; FRACTURES; EFFICACY; TRAUMA
AB Persistent wound drainage after hip arthroplasty is a risk factor for periprosthetic infection. Negative pressure wound therapy (NPWT) has been used in other fields for wound management although it is unclear whether the technique is appropriate for total hip arthroplasty.
   We determined (1) the rate of wound complications related to use of NPWT for persistent incisional drainage after hip arthroplasty; (2) the rate of resolution of incisional drainage using this modality; and (3) risk factors for failure of NPWT for this indication.
   In a pilot study we identified 109 patients in whom NPWT was used after hip arthroplasty for treating postoperative incisional drainage between April 2006 and April 2010. On average, the NPWT was placed on postoperative Day 3 to 4 (range, 2-9 days) and applied for 2 days (range, 1-10 days). We then determined predictors of subsequent surgery. Patients were followed until failure or a minimum of 1 year (average, 29 months; range, 1-62 months).
   Eighty-three patients (76%) had no further surgery and 26 patients (24%) had subsequent surgery: 11 had superficial irrigation and d,bridement (I&D), 12 had deep I&D with none requiring further surgery, and three ultimately had component removal. Predictors of subsequent surgery included international normalized ratio level greater than 2, greater than one prior hip surgery, and device application greater than 48 hours. There were no wound-related complications associated with NPWT.
   The majority of our patients had cessation of wound drainage with NPWT.
   Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
C1 [Hansen, Erik; Durinka, Joel B.; Costanzo, James A.; Austin, Matthew S.; Deirmengian, Gregory K.] Thomas Jefferson Univ Hosp, Rothman Inst Orthopaed, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University; Rothman Institute
RP Deirmengian, GK (通讯作者)，Thomas Jefferson Univ Hosp, Rothman Inst Orthopaed, 925 Chestnut St,5th Floor, Philadelphia, PA 19107 USA.
EM kirkor8@yahoo.com
RI Austin, Matthew/CAI-5870-2022
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NR 25
TC 40
Z9 50
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-921X
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD OCT
PY 2013
VL 471
IS 10
BP 3230
EP 3236
DI 10.1007/s11999-013-2937-3
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 216YU
UT WOS:000324323900029
PM 23539123
DA 2026-07-24
ER
PT J
AU De Martino, C
   Caiazzo, P
   Albano, M
   Calbi, F
   Pastore, M
   Tramutoli, PR
AF De Martino, Ciro
   Caiazzo, Paolo
   Albano, Michele
   Calbi, Francesco
   Pastore, Mauro
   Tramutoli, Pio Rocco
TI Laparostomy with topical negative pressure for treating severe
   peritonitis Preliminary experience with 16 cases and review of the
   literature
SO ANNALI ITALIANI DI CHIRURGIA
LA English
DT Article
DE Laparostomy; Peritonitis; Topical negative pressure
ID VACUUM-ASSISTED CLOSURE; LONG-TERM IMPACT; OPEN ABDOMEN; SECONDARY
   PERITONITIS; DAMAGE CONTROL; MANAGEMENT; THERAPY; TRAUMA
AB INTRODUCTION: The aim of this study was to assess the authors' initial experience with laparostomy and intraperitoneal topical negative pressure (TNP) in patients with severe peritonitis. The authors also reviewed the recent literature on the effectiveness and safety of abdominal TNP.
   PATIENTS AND METHODS: Sixteen patients (10 male, 6 female, mean age 55 years), suffering from severe peritonitis, underwent emergency laparotomy and laparostomy with TNP Abdominal sepsis originated from the small intestine (n = 7), large intestine (n = 6), biliary tract (n = 2), and pancreas (n = 1). In 2 patients abdominal wall mesh infection and soft tissue gangrene were observed.
   RESULTS: The mortality rate was 31.2%. The main complications probably related to TNP were enteric fistulae (25%), bleeding (25%), abdominal abscesses (12.5%), bowel ischemia (62%). Delayed primary closure was performed in 8 patients (57.1%) whereas in 6 cases a parietal graft was necessary, and one patient underwent an autologus skin graft.
   CONCLUSIONS: Laparostomy with intraperitoneal TNP is a safe and effective method for managing patients with severe peritonitis. Morbidity can be reduced through individualized application of the laparostomy dressing and pressure gradient. The abdominal wall should be managed in such a way as to make possible delayed primary closure.
C1 [De Martino, Ciro; Caiazzo, Paolo; Albano, Michele; Calbi, Francesco; Pastore, Mauro; Tramutoli, Pio Rocco] San Carlo Reg Hosp Potenza, Emergency Surg Unit, Potenza, Italy.
RP De Martino, C (通讯作者)，Via F Wenner 18, I-84080 Pellezzano, SA, Italy.
EM ciro.de@tiscali.it
OI De Martino, Ciro/0000-0001-6055-7802
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NR 24
TC 1
Z9 1
U1 0
U2 3
PU EDIZIONI LUIGI POZZI
PI ROME
PA VIA PANAMA 68, 00198 ROME, ITALY
SN 0003-469X
EI 2239-253X
J9 ANN ITAL CHIR
JI Ann. Ital. Chir.
PD JUL-AUG
PY 2013
VL 84
IS 4
BP 429
EP 436
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 217KI
UT WOS:000324358000012
PM 23917343
DA 2026-07-24
ER
PT J
AU Boettcher-Haberzeth, S
   Schiestl, C
AF Boettcher-Haberzeth, Sophie
   Schiestl, Clemens
TI Management of Avulsion Injuries
SO EUROPEAN JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE avulsion injury; children; Vacuum Assisted Closure system; Integra
   Dermal Regeneration Template
ID VACUUM-ASSISTED CLOSURE; DERMAL REGENERATION TEMPLATE; DEGLOVING
   INJURIES; LOWER-LIMB; SKIN; CONTRACTION; EXTREMITIES; CHILDREN; FLAP
AB The optimal management sequence to treat avulsion injuries in children is particularly difficult because of the following problems: (1) Assessment of these rare but frequently massive injuries can be very difficult and treacherous, as the extent of the injury is often underestimated and treatment therefore considered inappropriate; (2) Avulsion injuries have a high risk of infection: lesions are always contaminated due to the mechanism of injury (mostly vehicle accidents) and subsequent long-term hospitalization adds an additional risk for nosocomial infections; (3) Children with avulsion injuries have an increased risk to develop functional deficits: although the body grows, scars and reconstructed tissues may not adapt sufficiently and this may lead to serious constraints. Because of these problems, avulsion injuries may lead to a high morbidity and even mortality, especially if the injury is mismanaged. Reviewing the most recent data regarding the management of avulsion injuries yields the following key points: (1) A scoring system may help to assess the primary dimension of the defect; (2) Innovative techniques such as the use of a Vacuum Assisted Closure system may lower the risk of infection; (3) Choosing a comprehensive, reconstructive approach taking the growth of the child into consideration, may reduce the development of serious functional deficits and improve cosmetic outcome.
C1 [Boettcher-Haberzeth, Sophie; Schiestl, Clemens] Univ Childrens Hosp Zurich, Pediat Burn Ctr, Div Plast & Reconstruct Surg, Dept Surg, CH-8032 Zurich, Switzerland.
   [Boettcher-Haberzeth, Sophie] Univ Childrens Hosp Zurich, Tissue Biol Res Unit, Dept Surg, CH-8032 Zurich, Switzerland.
C3 University Children's Hospital Zurich; University Children's Hospital
   Zurich
RP Schiestl, C (通讯作者)，Univ Childrens Hosp Zurich, Pediat Burn Ctr, Div Plast & Reconstruct Surg, Dept Surg, CH-8032 Zurich, Switzerland.
EM clemens.schiestl@kispi.uzh.ch
RI Böttcher, Sophie/JBS-3818-2023
OI Böttcher, Sophie/0000-0002-7713-9807
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NR 21
TC 7
Z9 13
U1 0
U2 5
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0939-7248
EI 1439-359X
J9 EUR J PEDIATR SURG
JI Eur. J. Pediatr. Surg.
PD OCT
PY 2013
VL 23
IS 5
BP 359
EP 364
DI 10.1055/s-0033-1353493
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 220YO
UT WOS:000324623700004
PM 23982820
DA 2026-07-24
ER
PT J
AU Neuhaus, K
   Meuli, M
   Koenigs, I
   Schiestl, C
AF Neuhaus, Kathrin
   Meuli, Martin
   Koenigs, Ingo
   Schiestl, Clemens
TI Management of "Difficult" Wounds
SO EUROPEAN JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE negative pressure wound therapy; wound healing; immunosuppression;
   child; pressure sore
ID VACUUM-ASSISTED CLOSURE; PRESSURE SORES; NUTRITION; THERAPY; ULCERS;
   FLAPS
AB Pressure sores (PSs) and wounds in immunocompromised children are rather rare conditions. No doubt, their management is often complex and difficult, even for experienced pediatric plastic surgeons. As there are no algorithms for standard care, the therapeutic approach is individual. Successful PS management always implies primary and secondary prevention. With a PS present, rapid relief of pressure is crucial. If local wound care fails to restore skin integrity within a short period of time, surgical defect closure is mandatory. Overall, full-thickness skin grafts and local flap surgery are the most suitable methods regarding result quality, procedure complexity, and risks. Negative pressure wound therapy (NPWT) plays an instrumental role in wound bed preparation before definitive coverage. Recurrence rate is high (the complication). It does not much depend on the surgical technique employed, but rather depends on whether the various pathogenic factors leading to PS can be eliminated or alleviated. In both temporarily and permanently immunocompromised children, wound healing is significantly impaired. At the same time, these patients have no or low host defense activity. Thus, they are at high risk not only for local wound infection but also for potentially life threatening septic complications. Rapid and definitive wound closure is therefore essential. When conservative therapy fails, simple surgical techniques granting rapid and definitive wound closure should be used.
C1 [Neuhaus, Kathrin; Meuli, Martin; Schiestl, Clemens] Univ Childrens Hosp Zurich, Pediat Burn Ctr, Div Plast & Recontruct Surg, Dept Surg, CH-8032 Zurich, Switzerland.
   [Koenigs, Ingo] Univ Med Ctr Eppendorf, Dept & Clin Paediat Surg, Hamburg, Germany.
   [Koenigs, Ingo] Altonas Children Hosp, Hamburg, Germany.
C3 University Children's Hospital Zurich; University of Hamburg; University
   Medical Center Hamburg-Eppendorf
RP Neuhaus, K (通讯作者)，Univ Childrens Hosp Zurich, Pediat Burn Ctr, Div Plast & Recontruct Surg, Dept Surg, Steinwiesstr 75, CH-8032 Zurich, Switzerland.
EM kathrin.neuhaus@kispi.uzh.ch
OI Neuhaus, Kathrin/0000-0003-2438-1779
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NR 41
TC 12
Z9 13
U1 0
U2 22
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0939-7248
EI 1439-359X
J9 EUR J PEDIATR SURG
JI Eur. J. Pediatr. Surg.
PD OCT
PY 2013
VL 23
IS 5
BP 365
EP 374
DI 10.1055/s-0033-1354588
PG 10
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 220YO
UT WOS:000324623700005
PM 24008551
DA 2026-07-24
ER
PT J
AU Shweiki, E
   Gallagher, KE
AF Shweiki, Ehyal
   Gallagher, Kathy E.
TI Assessing a Safe Interval for Subsequent Negative Pressure Wound Therapy
   Change After Initial Placement in Acute, Contaminated Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; contamination; dressing changes
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; MANAGEMENT; INFECTIONS;
   DRESSINGS; DEFINITIONS; EXPERIENCE; SEPSIS; SYSTEM; TRIAL
AB Background. Negative pressure wound therapy (NPWT) is empirically expanding across the globe. Yet published data with NPWT in acute, contaminated wounds is limited, and several concerns arise regarding contemporary acute wound care NPWT practice. Specifically, there are no evidence-based time intervals Specifying when NPWT should be changed after initial placement in such Cases; therefore, NPWT was studied in acute, contaminated wounds. Methods. The authors retrospectively reviewed 86 consecutive patients, and a total of 97 contaminated wounds. All wounds were class IV, based on Centers for Disease Control and Prevention (CDC) criteria. All patients were managed with NPWT. Patient and wound-specific variables were analyzed. Outcome endpoints included durability of wound closure and death: Results. Mean time of subsequent NPWT after initial placement was 2.9 days, median time 3 days, mode 2 days, and standard deviation (SD) 1.24 days. Durability of wound closure was 73/79 (92%). Deaths were noted in 6/86 (7%) of patients. No deaths appeared related to NPWT. Conclusions. Based on the findings in this study, analyzing NPWT in the largest known patient cohort of this type, a time interval of 1.7 days to 4.1 days (mean time 2.9 days, SD 1.24), between initial and subsequent placement of NPWT in acute, contaminated wounds is safe and effective.
C1 [Shweiki, Ehyal] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA.
   [Gallagher, Kathy E.] Christiana Care Hlth Syst, Newark, DE 19713 USA.
C3 Thomas Jefferson University; Christiana Care Health System
RP Gallagher, KE (通讯作者)，Christiana Care Hlth Syst, Surg Crit Care, MAP 2,Suite 3301,4735 Ogletown Stanton Rd, Newark, DE 19713 USA.
EM kagallagher@christianacare.org
CR [Anonymous], MOR SEC WORLD OUR SH
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NR 40
TC 3
Z9 3
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2013
VL 25
IS 9
BP 263
EP 271
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 225MB
UT WOS:000324965900006
PM 25867242
DA 2026-07-24
ER
PT J
AU Van Noten, C
   van Doorn, KJ
   Vermander, E
   Vlayen, S
   Verpooten, GA
   Couttenye, MM
AF Van Noten, Charlotte
   van Doorn, Karin Janssen
   Vermander, Evert
   Vlayen, Sonja
   Verpooten, Gert A.
   Couttenye, Marie-Madeleine
TI Maximal conservative therapy of calcific uremic arteriolopathy
SO CLINICAL NEPHROLOGY
LA English
DT Article
DE calciphylaxis; cinacalcet; sodium thiosulfate; wound care
ID CALCIPHYLAXIS
AB We present the case of a 61-year-old female patient in long-term hemodialysis who developed calcific uremic arteriolopathy (CUA) upon administration of the oral calcimimetic agent cinacalcet for treatment of secondary hyperparathyroidism. In May 2009, the baseline serum values were parathormone (PTH) 310 pg/ml, calcium 9.1 mg/dl and phosphorous 6.9 mg/dl. Necrotic wounds in the suprapubic fat tissue were successfully treated first, by correcting the calcium phosphorous product; second, through treatment with sodium thiosulfate and third, through intensive wound care with hyperbaric oxygen therapy and vacuum-assisted closure therapy, with no need for parathyroidectomy. Multiple factors have been described to play a role in the development of CUA. Based on the findings of this case, the treatment of CUA should be aimed at correcting different causes simultaneously.
C1 [Van Noten, Charlotte; van Doorn, Karin Janssen; Verpooten, Gert A.; Couttenye, Marie-Madeleine] Univ Antwerp Hosp, Dept Nephrol Hypertens, B-2650 Antwerp, Belgium.
   [Vermander, Evert] Univ Antwerp Hosp, Dept Dermatol, B-2650 Antwerp, Belgium.
   [Vlayen, Sonja] Univ Antwerp Hosp, Dept Nursing, B-2650 Antwerp, Belgium.
   [Verpooten, Gert A.; Couttenye, Marie-Madeleine] Univ Antwerp, Antwerp, Belgium.
C3 University of Antwerp; University of Antwerp; University of Antwerp;
   University of Antwerp
RP Couttenye, MM (通讯作者)，Univ Antwerp Hosp, Dept Nephrol Hypertens, Wilrijkstr 10, B-2650 Antwerp, Belgium.
EM marie.couttenye@ua.ac.be
RI Couttenye, Marie/E-3473-2017
OI Couttenye, Marie/0000-0003-0324-2171
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   Weenig RH, 2007, J AM ACAD DERMATOL, V56, P569, DOI 10.1016/j.jaad.2006.08.065
NR 7
TC 1
Z9 1
U1 0
U2 1
PU DUSTRI-VERLAG DR KARL FEISTLE
PI DEISENHOFEN-MUENCHEN
PA BAHNHOFSTRASSE 9 POSTFACH 49, D-82032 DEISENHOFEN-MUENCHEN, GERMANY
SN 0301-0430
J9 CLIN NEPHROL
JI Clin. Nephrol.
PD JUL
PY 2012
VL 78
IS 1
BP 61
EP 63
DI 10.5414/CN107016
PG 3
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 226OU
UT WOS:000325046500009
PM 22732339
DA 2026-07-24
ER
PT J
AU Jong, JY
   Shim, H
   Lee, YJ
   Lee, SH
   Lee, JG
AF Jong, Ji Young
   Shim, Hongjin
   Lee, Yun Jin
   Lee, Seung Hwan
   Lee, Jae Gil
TI Application of negative pressure wound therapy in patients with wound
   dehiscence after abdominal open surgery: a single center experience
SO JOURNAL OF THE KOREAN SURGICAL SOCIETY
LA English
DT Article
DE Negative pressure wound therapy; Vacuum-assisted closure; Surgical wound
   dehiscence; Abdomen; Surgery
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; GUIDELINES; DEVICE; TRIAL
AB Purpose: Since the 1990's, negative pressure wound therapy (NPWT) has been used to treat soft tissue defects, burn wounds, and to achieve skin graft fixation. In the field of abdominal surgery, the application of NPWT is increasing in cases with an open abdominal wound requiring temporary wound closure and a second look operation. In the present study, the authors analyzed patients that underwent NPWT for postoperative wound dehiscence.
   Methods: The computerized records of patients that had undergone an abdominal operation from November 2009 to May 2012 were retrospectively analyzed.
   Results: The number of total enrolled patients was 50, and 30 patients (60%) underwent an emergency operation. Diagnoses were as follows: panperitonitis or intra-abdominal abscess (24 cases, 48%), intestinal obstruction (10 cases, 20%), cancer (7 cases, 14%), mesentery ischemia (3 cases, 6%), and hemoperitoneum (1 case, 2%). NPWT was applied at a mean of 12.9 +/- 8.2 days after surgery and mean NPWT duration was 17.9 days (2 to 96 days). The 11 patients (22%) with unsuccessful wound closure had a deeper and more complex wound than the other 39 patients (78%) (90.9% vs. 38.5%, P = 0.005). There were two complication cases (4%) due to delayed wound healing.
   Conclusion: Most patients recovered well due to granulation formation and suturing. NPWT was found to be convenient and safe, but a prospective comparative study is needed to confirm the usefulness of NPWT in patients whose wounds are dehisced.
C1 [Jong, Ji Young; Lee, Seung Hwan; Lee, Jae Gil] Yonsei Univ, Coll Med, Dept Surg, Seoul 120752, South Korea.
   [Shim, Hongjin] Yonsei Univ, Wonju Coll, Dept Surg, Wonju, South Korea.
   [Lee, Yun Jin] Severance Hosp, Dept Wound Ostomy Continence Nursing, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University; Severance Hospital
RP Lee, JG (通讯作者)，Yonsei Univ, Coll Med, Dept Surg, Severance Hosp, 50 Yonsei Ro, Seoul 120752, South Korea.
EM jakii@yuhs.ac
RI Lee, Jae Gil/O-1464-2017; Lee, Seung Hwan/AAE-4710-2022
OI Lee, Jae Gil/0000-0002-1148-8035; Lee, Seung Hwan/0000-0001-7325-8262;
   Jang, Ji Young/0000-0001-6372-4194
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 19
TC 5
Z9 6
U1 0
U2 4
PU KOREAN SURGICAL SOCIETY
PI SEOUL
PA 3304HO, 101 DONG, BROWNSTONE SEOUL, 335, JUNGMIN-DONG, JUNG-GU, SEOUL,
   100-859, SOUTH KOREA
SN 2233-7903
EI 2093-0488
J9 J KOREAN SURG SOC
JI J. Korean Surg. Soc.
PD OCT
PY 2013
VL 85
IS 4
BP 180
EP 184
DI 10.4174/jkss.2013.85.4.180
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 226SP
UT WOS:000325056600006
PM 24106685
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhou, M
   Yu, AX
   Wu, G
   Xia, CY
   Hu, X
   Qi, BW
AF Zhou, Min
   Yu, Aixi
   Wu, Gang
   Xia, Chengyan
   Hu, Xiang
   Qi, Baiwen
TI Role of different negative pressure values in the process of infected
   wounds treated by vacuum-assisted closure: an experimental study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Different negative pressure values; VAC; Vacuum-assisted closure; Wound
   healing
ID ENDOTHELIAL GROWTH-FACTOR; SUBATMOSPHERIC PRESSURE; THERAPY; EXPERIENCE;
   FREQUENCY; OUTCOMES; TRIAL
AB Vacuum-assisted closure (VAC) device is widely used to treat infected wounds in clinical work. Although the effect of VAC with different negative pressure values is well established, whether different negative pressures could result in varying modulation of wound relative cytokines was not clear. We hypothesise that instead of the highest negative pressure value the suitable value for VAC is the one which is the most effective on regulating wound relative cytokines. Infected wounds created on pigs' back were used to investigate the effects of varying negative pressure values of VAC devices. Wounds were treated with VAC of different negative pressure values or moist gauze, which was set as control. The VAC foam, semiocclusive dresses and moist gauze were changed on days 3, 5, 7 and 9 after wounds were created. When changing dressings, tissues from wounds were harvested for bacteria count and histology examination including Masson's trichrome stain and immunohistochemistry for microvessels. Western blot was carried out to test the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Results showed that on days 3 and 5 the number of bacteria in wounds treated by VAC with 75, 150, 225 and 300 mmHg was significantly decreased compared with that in wounds treated by gauze and 0 mmHg pressure value. However, there was no difference in wounds treated with negative pressure values of 75 , 150, 225 and 300 mmHg at any time spot. Immunohistochemistry showed that more microvessels were generated in wounds treated by VAC using 75 and 150 mmHg negative pressure comparing with that using 225 and 300 mmHg on days 3 and 5. However this difference vanished on days 7 and 9. Morphological evaluation by Masson's trichrome staining showed increased collagen deposition in VAC of 75 and 150 mmHg compared with that in VAC of 225 and 300 mmHg. Western blot showed that the expression of VEGF and bFGF significantly increased when the wounds treated with 75 and 150 mmHg negative pressure values compared with the wounds treated with 225 and 300 mmHg on day 5. Treatment using VAC with different negative pressure values more than 75 mmHg has similar efficiency on reducing bacteria in the infected wound. VAC with negative pressure values of 75 and 150 mmHg promote wound healing more quickly than other pressure values. Moreover, comparing with vigorous negative pressure, relatively moderate pressures contribute to wound healing via accelerated granulation growth, increased angiogenic factor production and improved collagen fibre deposition. Further study of this model may show other molecular mechanisms.
C1 [Zhou, Min; Yu, Aixi; Wu, Gang; Xia, Chengyan; Hu, Xiang; Qi, Baiwen] Wuhan Univ, Zhongnan Hosp, Dept Microorthoped, Wuhan 430071, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Microorthoped, 169 Donghu Rd, Wuhan 430071, Peoples R China.
EM yuaixi666@163.com
OI Yu, Aixi/0000-0002-3751-0894
FU National Natural Science Funds of China [81171713]
FX The authors would like to thank Chen Wei-ming for his instruction on
   this trial, and thank VSD company (Wuhan, China) for supplying vacuum
   pump, open-pore foam and semiocclusive dressing. This study was financed
   by the National Natural Science Funds of China. Project code: 81171713.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 33
TC 36
Z9 44
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2013
VL 10
IS 5
BP 508
EP 515
DI 10.1111/j.1742-481X.2012.01008.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 227DW
UT WOS:000325090300006
PM 22640026
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Malmsjö, M
   Ingemansson, R
   Lindstedt, S
   Gustafsson, L
AF Malmsjo, Malin
   Ingemansson, Richard
   Lindstedt, Sandra
   Gustafsson, Lotta
TI Comparison of bacteria and fungus-binding mesh, foam and gauze as
   fillers in negative pressure wound therapy - pressure transduction,
   wound edge contraction, microvascular blood flow and fluid retention
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Blood flow; Experimental surgery; Negative pressure wound therapy; Wound
   dressing; Wound healing
ID VACUUM-ASSISTED CLOSURE; EVIDENCE-BASED RECOMMENDATIONS; PERISTERNAL
   THORACIC WALL; MATRIX METALLOPROTEINASES; STEPS
AB Bacteria- and fungus-binding mesh binds with and inactivates bacteria and fungus, which makes it an interesting alternative, wound filler for negative pressure wound therapy (NPWT). This study was conducted to compare the performance of pathogen-binding mesh, foam and gauze as wound fillers in NPWT with regard to pressure transduction, fluid retention, wound contraction and microvascular blood flow. Wounds on the backs of 16 pigs were filled with pathogen-binding mesh, foam or gauze and treated with NPWT. The immediate effects of 0, -40, -60, -80 and -120 mmHg, on pressure transduction and blood flow were examined in eight pigs using laser Doppler velocimetry. Wound contraction and fluid retention were studied during 72 hours of NPWT at -80 and -120 mmHg in the other eight pigs. Pathogen-binding mesh, gauze and foam provide similar pressure transduction to the wound bed during NPWT. Blood flow was found to decrease 05 cm laterally from the wound edge and increase 25 cm from the wound edge, but was unaltered 50 cm from the wound edge. The increase in blood flow was similar with all wound fillers. The decrease in blood flow was more pronounced with foam than with gauze and pathogen-binding mesh. Similarly, wound contraction was more pronounced with foam, than with gauze and pathogen-binding mesh. Wound fluid retention was the same in foam and pathogen-binding mesh, while more fluid was retained in the wound when using gauze. The blood flow 05-5 cm from the wound edge and the contraction of the wound during NPWT were similar when using pathogen-binding mesh and gauze. Wound fluid was efficiently removed when using pathogen-binding mesh, which may explain previous findings that granulation tissue formation is more rapid under pathogen-binding mesh than under gauze. This, in combination with its pathogen-binding properties, makes this mesh an interesting wound filler for use in NPWT.
C1 [Malmsjo, Malin; Gustafsson, Lotta] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Ingemansson, Richard; Lindstedt, Sandra] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University
RP Malmsjö, M (通讯作者)，Lund Univ, Dept Ophthalmol, Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Ingemansson,
   Richard/0000-0001-7623-8953; Maljö, Malin/0000-0001-9849-9599;
   Gustafsson, Lotta/0000-0002-9826-9133
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NR 37
TC 13
Z9 20
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2013
VL 10
IS 5
BP 597
EP 605
DI 10.1111/j.1742-481X.2012.01029.x
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 227DW
UT WOS:000325090300019
PM 22716081
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Upton, D
   Andrews, A
AF Upton, D.
   Andrews, A.
TI Negative pressure wound therapy: improving the patient experience Part 1
   of 3
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; pain; patient experience; skin trauma;
   stress; wound treatment
ID DIABETIC FOOT ULCERS; PAIN; STRESS; IMPACT; CARE
AB Negative pressure wound therapy (NPWT) is an effective treatment for healing wounds, which may have additional benefits, such as reduced time spent in hospital and fewer dressing changes. However, as with most wound treatments, NPWT can be painful for some patients. Research has shown that the pain and accompanying stress of wound care can impair patient quality of life and delay the healing process, highlighting the need to explore ways in which the patient experience of NPWT might be improved. This article presents part one of three studies which aimed to investigate the above. In the present study, an online survey was used to explore the views of wound care clinicians worldwide (n = 221) on NPWT and levels of pain, stress and skin trauma in patients during the different stages of treatment. Findings suggest that, in the opinion of clinicians, patients' pain levels vary during the different stages of NPWT and that removal of the wound fillers and dressings or covering films are the most painful stages.
C1 [Upton, D.; Andrews, A.] Univ Worcester, Inst Hlth & Soc, Worcester, MA USA.
RP Upton, D (通讯作者)，Univ Worcester, Inst Hlth & Soc, Worcester, MA USA.
EM d.upton@worc.ac.uk
OI Upton, Dominic/0000-0002-5547-6204
FU Molnlycke Health Care
FX This study was supported by a financial grant from Molnlycke Health
   Care. The authors have no commercial or social conflicts of interest
   with respect to the article or its content.
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NR 34
TC 6
Z9 9
U1 0
U2 15
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2013
VL 22
IS 10
BP 552
EP 557
DI 10.12968/jowc.2013.22.10.552
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 228JS
UT WOS:000325182900005
PM 24142077
DA 2026-07-24
ER
PT J
AU He, XF
   Hu, Y
   Ye, PH
   Huang, L
   Zhang, F
   Ruan, YP
AF He, Xianfeng
   Hu, Yong
   Ye, Penghan
   Huang, Lei
   Zhang, Feng
   Ruan, Yongping
TI The operative treatment of complex pilon fractures: A strategy of soft
   tissue control
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Negative pressure wound therapy; pilon fractures; soft tissue control;
   staged protocol
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; PRESSURE WOUND
   THERAPY; BLOOD-FLOW; NEGATIVE-PRESSURE; INTERNAL-FIXATION; TIBIAL
   PLAFOND; OPEN REDUCTION; MANAGEMENT
AB Background: Pilon fractures are challenging to manage because of the complexity of the injury pattern and the risk of significant complications. The soft tissue injury and handling of the soft tissue envelope are crucial in pilon fracture outcomes. The purpose of this study was to evaluate the early rate of complications using the strategy of "soft tissue control" for operative treatment of complex pilon fractures.
   Materials and Methods: 36 complex pilon fractures were treated with the "soft tissue control" strategy. Patients followed the standard staged protocol, anterolateral approach to the distal tibia, the "no-touch" technique and incisional negative pressure wound therapy for pilon fractures. Patients were examined clinically at 2-3 weeks and then 8 weeks for complications associated with the surgical technique.
   Results: All fractures were AO/OTA (Orthopaedic Trauma Association) type C fractures (61% C3, 22% C2 and 16% C1). Only one patient developed superficial infection and resolved with antibiotics and local wound care. None developed deep infection.
   Conclusions: The strategy of soft tissue control for treatment of pilon fractures resulted in relatively low incidence of early wound complications in patients with complex pilon fractures.
C1 [He, Xianfeng; Hu, Yong; Ye, Penghan; Huang, Lei; Zhang, Feng; Ruan, Yongping] Ningbo 6 Hosp, Dept Orthoped Surg, Ningbo 315040, Zhejiang, Peoples R China.
RP He, XF (通讯作者)，Ningbo 6 Hosp, Dept Orthoped Surg, East Zhongshan Rd 1059, Ningbo 315040, Zhejiang, Peoples R China.
EM hexianfeng120@163.com
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NR 25
TC 9
Z9 18
U1 0
U2 9
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD SEP-OCT
PY 2013
VL 47
IS 5
BP 487
EP 492
DI 10.4103/0019-5413.118205
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 231FJ
UT WOS:000325400200010
PM 24133309
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Marinovic, M
   Bakota, B
   Spanjol, J
   Sosa, I
   Grzalja, N
   Gulan, G
   Ivancic, A
   Cicvaric, T
AF Marinovic, Marin
   Bakota, Bore
   Spanjol, Josip
   Sosa, Ivan
   Grzalja, Nikola
   Gulan, Gordan
   Ivancic, Aldo
   Cicvaric, Tedi
TI High pressure injection injury of the foot: a role of negative pressure
   wound therapy
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE High pressure injection injury; Foot injury; Negative pressure wound
   therapy (NPWT)
ID GREASE-GUN INJURY; HAND; WATER
AB High pressure injection injuries (HPII) of the foot are not common in every-day practice. We present a 50-year-old patient with a HPII of the left foot caused by water-gun in a self-inflicted accident working as a technical diver four meters under the sea surface. Surgical treatment included extensive debridement of necrotic tissue and fibrin deposits and removal of foreign material. A negative pressure wound therapy (NPWT) device was applied resulting in a good wound base for subsequent skin grafting leading to a good functional and cosmetic outcome. (c) 2013 Elsevier Ltd. All rights reserved.
C1 [Marinovic, Marin; Grzalja, Nikola; Cicvaric, Tedi] Univ Hosp Rijeka, Dept Traumatol, Rijeka 51000, Croatia.
   [Bakota, Bore] Gen Hosp Karlovac, Dept Traumatol, Karlovac, Croatia.
   [Spanjol, Josip] Univ Hosp Rijeka, Dept Urol, Rijeka 51000, Croatia.
   [Sosa, Ivan] Dept Forens Med & Criminalist, Rijeka, Croatia.
   [Gulan, Gordan] Clin Ortopaed Lovran, Lovran, Croatia.
   [Ivancic, Aldo] Univ Hosp Rijeka, Dept Thoracovasc Surg, Rijeka 51000, Croatia.
C3 University of Rijeka; University of Rijeka; University of Rijeka
RP Marinovic, M (通讯作者)，Univ Hosp Rijeka, Dept Traumatol, Tome Strizica 3, Rijeka 51000, Croatia.
EM marin.marinovic2@gmail.com
RI ; Šoša, Ivan/F-3562-2011; Bakota, Bore/PSM-5323-2026; Španjol,
   Josip/O-3756-2018; Marinovic, Marin/O-4285-2019
OI Grzalja, Nikola/0000-0001-9141-1830; Šoša, Ivan/0000-0002-6869-3734;
   Bakota, Bore/0000-0001-9840-369X; Španjol, Josip/0000-0002-5551-8128; 
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NR 23
TC 2
Z9 4
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD SEP
PY 2013
VL 44
SU 3
BP S7
EP S10
PG 4
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 231PT
UT WOS:000325430100003
PM 24060024
DA 2026-07-24
ER
PT J
AU de Runz, A
   Zuily, S
   Gosset, J
   Wahl, D
   Simon, E
AF de Runz, Antoine
   Zuily, Stephane
   Gosset, Jessica
   Wahl, Denis
   Simon, Etienne
TI Particular catastrophic antiphospholipid syndrome, on the sole surgical
   site after breast reduction
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Mammaplasty; Antiphospholipid syndrome; Skin necrosis; Negative-pressure
   wound therapy; Skin transplantation; Skin artificial
ID PRESSURE WOUND THERAPY
AB A 20-year-old woman treated with vitamin K antagonist for antiphospholipid syndrome (APS) (pulmonary embolisms at age 15) was admitted for breast reduction after bridging therapy. At 2 days post-surgery haematomas appeared on the surgical site and anticoagulant therapy was withheld. She developed a skin and breast necrosis leading to the diagnosis of catastrophic APS. Despite medical treatment (anticoagulant therapy, corticosteroids and intravenous immunoglobulins) and surgery, necrosis continued. After 2 weeks of negative-pressure wound therapy (V.A.C.(R) Therapy (TM)) the patient improved, mammary tissues were alive, well vascularised and budding. Breast reconstruction was then initiated. Artificial dermis graft (MatriDerm (R) 2 mm) was applied, and 3 weeks later the apposition of split-thickness skin graft on it. Six months later, results of the surgery were good and the patient was satisfied. (C) 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [de Runz, Antoine; Simon, Etienne] Nancy Univ Hosp, Dept Maxillofacial Plast Reconstruct & Cosmet Sur, Nancy, France.
   [Zuily, Stephane; Wahl, Denis] Nancy Univ Hosp, Vasc Med Div, Nancy, France.
   [Zuily, Stephane; Wahl, Denis] Nancy Univ Hosp, Reg Competence Ctr Rare Vasc & Syst Autoimmune Di, Nancy, France.
   [Zuily, Stephane; Wahl, Denis; Simon, Etienne] Univ Lorraine, Nancy, France.
   [Zuily, Stephane; Wahl, Denis] INSERM, UMR S 1116, Nancy, France.
   [Gosset, Jessica] Clin Villa Isabey, Nancy, France.
C3 CHU de Nancy; CHU de Nancy; CHU de Nancy; Universite de Lorraine;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Lorraine
RP de Runz, A (通讯作者)，Serv Chirurg Maxillofaciale Plast Reconstructrice, 29 Ave Marechal de Lattre de Tassigny, F-54000 Nancy, France.
EM antoine@email.com
OI de Runz, Antoine/0000-0003-1213-0710
CR Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
   Cervera R, 2009, J AUTOIMMUN, V32, P240, DOI 10.1016/j.jaut.2009.02.008
   Eisenhardt SU, 2012, J PLAST RECONSTR AES, V65, P640, DOI 10.1016/j.bjps.2011.11.037
   Erkan D, 2010, AUTOIMMUN REV, V10, P74, DOI 10.1016/j.autrev.2010.08.005
   Jacobs S, 2009, J PLAST RECONSTR AES, V62, P1331, DOI 10.1016/j.bjps.2008.03.024
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   Kiney AV, 2008, LUPUS, V17, P952, DOI 10.1177/0961203308096662
NR 7
TC 5
Z9 5
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD NOV
PY 2013
VL 66
IS 11
BP E321
EP E324
DI 10.1016/j.bjps.2013.04.037
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 232CM
UT WOS:000325466700006
PM 23680115
DA 2026-07-24
ER
PT J
AU Isaac, AL
   Armstrong, DG
AF Isaac, Adam L.
   Armstrong, David G.
TI Negative Pressure Wound Therapy and Other New Therapies for Diabetic
   Foot Ulceration The Current State of Play
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Negative pressure wound therapy; Wound chemotherapy; Diabetic foot
   ulcer; Theragnostics
ID VACUUM-ASSISTED CLOSURE; AMPUTATION-PREVENTION; MULTICENTER; ULCERS;
   SYSTEM
AB Up to 25% of people with diabetes will develop a foot ulcer, with 1 in 5 ulcers requiring an amputation. An interdisciplinary team approach to limb salvage, combined with a vertical and horizontal strategy for wound healing, may help to systematically simplify what is a complex process. The organization and integration of care, with an emphasis placed on identifying key diagnostic points in healing and warning signs for recurrence, will be instrumental in improving outcomes in patients with diabetes and complicated foot wounds.
C1 [Isaac, Adam L.; Armstrong, David G.] Univ Arizona, Coll Med, Dept Surg, SALSA, Tucson, AZ 85724 USA.
C3 University of Arizona
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, Dept Surg, SALSA, 1501 North Campbell Ave, Tucson, AZ 85724 USA.
EM armstrong@usa.net
RI Isaac, Adam/L-9111-2019
OI Isaac, Adam/0000-0001-5338-3445
FU KCI; Spiracur
FX Dr Isaac reports no conflict of interest. Dr Armstrong has received
   research support from KCI and Spiracur and serves on the scientific
   advisory board of Spiracur.
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
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   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Armstrong DG, DIABETES CA IN PRESS
   Armstrong DG, OSTOMY WOUND MANAG S, V50, p3S
   Blitz NM, 2006, LOWER EXTREMITY SOFT, P343
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Driver VR, 2010, J VASC SURG, V52, p17S, DOI 10.1016/j.jvs.2010.06.003
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   Giovinco Nicholas A, 2010, Eplasty, V10, pe9
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NR 40
TC 31
Z9 38
U1 0
U2 30
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD SEP
PY 2013
VL 97
IS 5
BP 899
EP +
DI 10.1016/j.mcna.2013.03.015
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 232TA
UT WOS:000325516100011
PM 23992900
OA Bronze
DA 2026-07-24
ER
PT J
AU Sharp, E
AF Sharp, E.
TI Single-use NPWT for the treatment of complex orthopaedic surgical and
   trauma wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; orthopaedic; portable; improving
   outcomes
ID VACUUM-ASSISTED CLOSURE; TIBIAL PILON FRACTURES; THERAPY
AB Orthopaedic limb reconstruction patients often have wounds that are difficult to heal either due to the underlying problems, their surgery, underlying comorbidities or a combination of these factors. Negative pressure wound therapy (NPWT) is a useful tool with which to manage these wounds; however, many systems are not ideal for use in the patient's home, due in part to size and complexity. There are also staff training issues if transferring patients to an area which does not routinely use negative pressure systems. This paper reports the outcomes for some of the patients who were treated with a novel, single-use NPWT device in a orthopaedic trauma/limb reconstruction unit.
C1 Glasgow Royal Infirm, Glasgow, Lanark, Scotland.
C3 University of Glasgow
RP Sharp, E (通讯作者)，Glasgow Royal Infirm, Gatehouse Bldg, Glasgow, Lanark, Scotland.
EM emma.sharp@ggc.scot.nhs.uk
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Harding Keith, 2007, Int Wound J, V4 Suppl 2, P1
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NR 15
TC 6
Z9 7
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2013
VL 22
IS 10
SU S
BP S5
EP S9
DI 10.12968/jowc.2013.22.Sup10.S5
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 234XH
UT WOS:000325677100002
PM 24142141
DA 2026-07-24
ER
PT J
AU Agostini, T
   Dini, M
   Li, AQ
   Grassetti, L
   Mori, A
   Spinelli, G
   Lo Russo, G
   Lazzeri, D
AF Agostini, Tommaso
   Dini, Mario
   Li, Alessandro Quattrini
   Grassetti, Luca
   Mori, Andrea
   Spinelli, Giuseppe
   Lo Russo, Giulia
   Lazzeri, Davide
TI A novel combined surgical approach to head and neck dermatofibrosarcoma
   protuberans
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Dermatofibrosarcoma protuberans; Head and neck; Vacuum-assisted closure;
   Dermal regenerative template; Skin graft
ID MICROSURGICAL RECONSTRUCTION; SUBATMOSPHERIC PRESSURE; INTEGRA; SURGERY;
   SKIN; DEFECTS; REGION
AB Introduction: The surgical management of dermatofibrosarcoma protuberans has historically been a challenge, particularly in the head and neck and other aesthetic areas. The current priority is to achieve local oncologic control and a good reconstructive outcome. Here, we present our experience using a novel combined approach with a dermal regenerative template, sub-atmospheric pressure and skin graft.
   Materials and methods: Five patients presenting at the Department of Plastic and Reconstructive Surgery of the University of Florence between January 2010 and October 2011 were included in the study following Institutional Review Board approval. All patients underwent a wide local excision of dermatofibrosarcoma protuberans affecting the head and neck.
   Results: The combined approach using the negative-pressure device, a dermal regenerative template and skin grafting proved effective in the management of this type of sarcoma with a good aesthetic and functional outcome, particularly on the neck or the supraclavicular region.
   Conclusion: Although the present multi-step technique requires patient compliance, it results in good local oncologic control of the resection margins. It is possible to perform a wider excision in the event of positive margins without interfering with the last reconstructive outcome. (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Agostini, Tommaso; Dini, Mario; Li, Alessandro Quattrini; Mori, Andrea; Lo Russo, Giulia] Univ Florence, CTO AOUC, Dept Plast & Reconstruct, I-50134 Florence, Italy.
   [Agostini, Tommaso; Spinelli, Giuseppe] Univ Florence, CTO AOUC, Dept Maxillo Facial Surg, I-50121 Florence, Italy.
   [Lazzeri, Davide] Hosp Cisanello, Dept Plast & Reconstruct Surg, Pisa, Italy.
C3 University of Florence; University of Florence
RP Agostini, T (通讯作者)，Univ Florence, Fac Med, CTO AOUC, Dept Plast & Reconstruct Surg, Largo Palagi 1, I-50100 Florence, Italy.
EM tommasoagostini@ymail.com
RI Agostini, Tommaso/G-5688-2011
OI Agostini, Tommaso/0000-0001-6743-5218; Grassetti,
   Luca/0000-0002-8856-7997
CR Bianchi B, 2011, J CRANIO MAXILL SURG, V39, P289, DOI 10.1016/j.jcms.2010.05.005
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NR 18
TC 15
Z9 17
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD OCT
PY 2013
VL 41
IS 7
BP 681
EP 685
DI 10.1016/j.jcms.2013.01.009
PG 5
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 236YI
UT WOS:000325835000025
PM 23485484
DA 2026-07-24
ER
PT J
AU Munguía-Canales, DA
   Vargas-Mendoza, GK
   Alvarez-Bestoff, G
   Calderón-Abbo, MC
AF Alejandro Munguia-Canales, Daniel
   Kosai Vargas-Mendoza, Gary
   Alvarez-Bestoff, Gustavo
   Cutiel Calderon-Abbo, Moises
TI Management of Pleural Empyema With a Vacuum-Assisted Closure Device and
   Reconstruction of Open Thoracic Window in a Patient With Liver Cirrhosis
SO ARCHIVOS DE BRONCONEUMOLOGIA
LA Spanish
DT Article
DE Liver cirrhosis; Pleural empyema; Vacuum-assisted closure device
ID INTRATHORACIC APPLICATION; SURGERY; POSTPNEUMONECTOMY; THERAPY; OPTION
AB The patient is a 21-year-old female, diagnosed with cryptogenic cirrhosis at the age of 9. She presented with left post-pneumonic empyema that did not remit with conventional medical management and evolved with fistulization to the skin in the 7th intercostal space in the left subscapular region. We performed an open thoracic window procedure, and on the 6th day the patient was sent home with a portable vacuum-assisted closure device, with changes of the material every 4 days until the cavity was completed obliterated (92 days). Imaging tests showed full expansion of the lung, and chest wall reconstruction was performed with titanium rods. The high mortality of empyema in patients with liver disease requires both implementing and searching for new adjuvant therapies, like the use of vacuum-assisted closure systems and reconstruction with titanium rods. Controlled studies with a wide range of cases are needed for proper evaluation. (C) 2012 SEPAR. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Alejandro Munguia-Canales, Daniel; Kosai Vargas-Mendoza, Gary; Alvarez-Bestoff, Gustavo; Cutiel Calderon-Abbo, Moises] Hosp Cardiol, Serv Cirugia Torac, Ctr Med Nacl Siglo 21, IMSS, Mexico City, DF, Mexico.
C3 Instituto Mexicano del Seguro Social
RP Munguía-Canales, DA (通讯作者)，Hosp Cardiol, Serv Cirugia Torac, Ctr Med Nacl Siglo 21, IMSS, Mexico City, DF, Mexico.
EM munguia.cirujano@gmail.com
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   Renner C, 2010, ANN THORAC SURG, V89, P603, DOI 10.1016/j.athoracsur.2009.06.037
   Rocco G, 2012, EUR J CARDIO-THORAC, V41, P1069, DOI 10.1093/ejcts/ezr196
   Saadi A, 2011, ANN THORAC SURG, V91, P1582, DOI 10.1016/j.athoracsur.2011.01.018
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NR 19
TC 4
Z9 8
U1 0
U2 1
PU EDICIONES DOYMA S A
PI BARCELONA
PA TRAV DE GRACIA 17-21, 08021 BARCELONA, SPAIN
SN 0300-2896
EI 1579-2129
J9 ARCH BRONCONEUMOL
JI Arch. Bronconeumol.
PD OCT
PY 2013
VL 49
IS 10
BP 447
EP 449
DI 10.1016/j.arbres.2012.11.003
PG 3
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 237YQ
UT WOS:000325908000006
PM 23312986
DA 2026-07-24
ER
PT J
AU Stanley, BJ
   Pitt, KA
   Weder, CD
   Fritz, MC
   Hauptman, JG
   Steficek, BA
AF Stanley, Bryden J.
   Pitt, Kathryn A.
   Weder, Christian D.
   Fritz, Michele C.
   Hauptman, Joe G.
   Steficek, Barbara A.
TI Effects of Negative Pressure Wound Therapy on Healing of Free
   Full-Thickness Skin Grafts in Dogs
SO VETERINARY SURGERY
LA English
DT Article
ID VACUUM-ASSISTED-CLOSURE; MICROVASCULAR BLOOD-FLOW; POLYURETHANE-FOAM;
   CONTROLLED-TRIAL; MANAGEMENT; DRESSINGS; DEVICE; GAUZE; OSTEOMYELITIS;
   TRANSDUCTION
AB Objective To compare healing of free, full-thickness, meshed skin grafts under negative pressure wound therapy (NPWT) with bolster dressings in dogs. Study design Randomized, controlled experimental study, paired design. Animals Dogs (n=5) Methods Full-thickness skin wounds (4cmx1.5cm) were created bilaterally on the antebrachia of 5 dogs (n=10). Excised skin was grafted to the contralateral limb. Grafts were randomized to NPWT or bolster dressings (control; CON). NPWT was applied continuously for 7 days. Grafts were evaluated on Days 2, 4, 7, 10, 14, and 17, biopsied on days 0, 4, 7, and 14, and had microbial culture on Day 7. Outcome variables were: time to first appearance of granulation tissue, percent graft necrosis, and percent open mesh. Significance was set at P<.05. Histologic findings, culture results, and graft appearance were reported. Results Granulation tissue appeared earlier in the NPWT grafts compared with CON grafts. Percent graft necrosis and remaining open mesh area were both greater in CON grafts compared with NPWT grafts at most time points. Histologic results showed no significant difference in all variables measured, and all cultures were negative. Conclusions Variables of graft acceptance were superior when NPWT was used in the first week post-grafting. Fibroplasia was enhanced, open meshes closed more rapidly and less graft necrosis occurred with NPWT application. More preclinical studies are required to evaluate histologic differences.
C1 [Stanley, Bryden J.; Pitt, Kathryn A.; Weder, Christian D.; Fritz, Michele C.; Hauptman, Joe G.] Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
   [Steficek, Barbara A.] Michigan State Univ, Coll Vet Med, Diagnost Ctr Populat, E Lansing, MI 48824 USA.
C3 Michigan State University; Michigan State University
RP Stanley, BJ (通讯作者)，Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
EM stanle32@cvm.msu.edu
OI Fritz, Michele/0000-0002-4146-2469
FU Michigan Animal Health Foundation; Michigan Veterinary Medical
   Association; NIH [5T35RR017491-07]
FX Contract grant sponsor: Michigan Animal Health Foundation, Michigan
   Veterinary Medical Association; Contract grant sponsor: NIH; Contract
   grant number: 5T35RR017491-07.
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NR 61
TC 52
Z9 61
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD JUN
PY 2013
VL 42
IS 5
BP 511
EP 522
DI 10.1111/j.1532-950X.2013.12005.x
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 238DA
UT WOS:000325919700003
PM 23550662
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Kepa, K
   Krzych, L
   Waclawczyk, T
   Krejca, M
AF Kepa, Krzysztof
   Krzych, Lukasz
   Waclawczyk, Tomasz
   Krejca, Michal
TI The use of negative pressure wound therapy in the treatment of wound
   infections - a single-center 12-month experience
SO KARDIOCHIRURGIA I TORAKOCHIRURGIA POLSKA-POLISH JOURNAL OF THORACIC AND
   CARDIOVASCULAR SURGERY
LA English
DT Article
DE cardiac surgery; infection; treatment; NPWT; VAC
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTION; RISK; MEDIASTINITIS
AB Background: The prevalence of surgical site infections (SSI) in cardiac surgery is about 0.5-10%, according to different sources, and leads to a prolonged hospital stay and higher mortality.
   The aim of the study was to describe the clinical outcomes of our 12-month experience using negative pressure wound therapy (NPWT).
   Material and methods: We performed a retrospective analysis of 32 patients undergoing NPWT between October 1, 2011 and September 30, 2012 (i.e. 2.7% of all patients who underwent surgical treatment in this period). Patient characteristics, risk factors, and procedure-related variables were analyzed and compared in two groups: group 1 included patients with infection of skin and subcutaneous tissue (1.2%), while group 2 consisted of patients with mediastinitis (1.6%).
   Results: Mediastinitis was three times more frequent among women (p = 0.09) and diabetics (p = 0.08), and four times more frequent in patients with chronic obstructive pulmonary disease (p = 0.2). The most frequently performed procedure was coronary artery bypass grafting (87.5%). Methicillin-resistant Staphylococcus epidermidis (26.2%) and Pseudomonas aeruginosa (21%) were the pathogens that were most frequently isolated from the infected wounds. The mean time of hospitalization was 64 +/- 35 days, which was similar in the two studied groups. In-hospital mortality in the mediastinitis group was 16.7%; no deaths were related to the use of NPWT therapy.
   Results: Our findings indicate that NPWT is a viable option for SSI treatment. Moreover, the use of NPWT may lower patient mortality, as well as reduce the length and costs of hospitalization. In order to achieve this, however, it is necessary to diagnose the infection early and to implement adequate treatment.
C1 [Kepa, Krzysztof; Krzych, Lukasz; Waclawczyk, Tomasz; Krejca, Michal] Gornoslaskie Ctr Med Katowicach, Oddzial Kardiochirurg, Katowicach, Poland.
RP Kepa, K (通讯作者)，Slaska 18-1, PL-40741 Katowice, Poland.
EM kepa.krzysiek@gmail.com
OI Wacławczyk, Tomasz/0000-0001-6504-2779; Krzych,
   Lukasz/0000-0002-5252-8398
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
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NR 14
TC 1
Z9 1
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1731-5530
EI 1897-4252
J9 KARDIOCHIR TORAKOCHI
JI Kardiochirurgia Torakochirurg. Pol.
PD SEP
PY 2013
VL 10
IS 3
BP 204
EP 210
DI 10.5114/kitp.2013.38093
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 239EB
UT WOS:000326004300003
OA gold
DA 2026-07-24
ER
PT J
AU Hedley, J
   Woods, S
   Eatwell, K
AF Hedley, J.
   Woods, S.
   Eatwell, K.
TI The use of negative pressure wound therapy following subcarapacial
   abscess excision in a tortoise
SO JOURNAL OF SMALL ANIMAL PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; TURTLES; DOGS
AB A 42-year-old female Testudo graeca was referred with a five-month history of a non-healing carapacial wound. Previous treatment had involved long-term antibiotic therapy and conscious debridement of necrotic tissue. On presentation an extensive deep wound with purulent discharge was visible on the right side of the carapace. A computed tomographic scan was performed to assess the extent of the wound. This revealed a large carapacial deficit with two underlying soft tissue masses. Surgical debridement was performed under general anaesthesia resulting in an even larger defect. Because of the extensive nature of the deficit, negative pressure wound therapy was applied to aid wound healing. A negative pressure of approximately 120mmHg was maintained and bandages were changed every third day. Wound healing progressed rapidly and a healthy granulation bed was formed within 16 days.
C1 [Hedley, J.] Univ Edinburgh, Royal Dick Sch Vet Studies, Hosp Small Anim, Easter Bush Vet Ctr, Roslin EH25 9RG, Midlothian, Scotland.
   Univ Edinburgh, Roslin Inst, Roslin EH25 9RG, Midlothian, Scotland.
C3 University of Edinburgh; University of Edinburgh; UK Research &
   Innovation (UKRI); Biotechnology and Biological Sciences Research
   Council (BBSRC); Roslin Institute
RP Hedley, J (通讯作者)，Univ Edinburgh, Royal Dick Sch Vet Studies, Hosp Small Anim, Easter Bush Vet Ctr, Roslin EH25 9RG, Midlothian, Scotland.
RI Woods, Samantha/MFI-5154-2025
OI Woods, Samantha/0009-0003-8265-5819
CR Adkesson MJ, 2007, JAVMA-J AM VET MED A, V231, P1249, DOI 10.2460/javma.231.8.1249
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Barten S L., 2006, Reptile Medicine and Surgery, V2nd, P893
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   Coke Rob L., 2006, Journal of Herpetological Medicine and Surgery, V16, P102
   Demaria M, 2011, VET SURG, V40, P658, DOI 10.1111/j.1532-950X.2011.00849.x
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   Maclean B., 2004, MANUAL REPTILE MED, P63
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   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Mullally C, 2010, J VET EMERG CRIT CAR, V20, P456, DOI 10.1111/j.1476-4431.2010.00564.x
   Safdar A, 2007, CLIN INFECT DIS, V45, P1602, DOI 10.1086/522998
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
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NR 24
TC 3
Z9 6
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4510
EI 1748-5827
J9 J SMALL ANIM PRACT
JI J. Small Anim. Pract.
PD NOV
PY 2013
VL 54
IS 11
BP 610
EP 613
DI 10.1111/jsap.12118
PG 4
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 241LS
UT WOS:000326169000010
PM 23889043
DA 2026-07-24
ER
PT J
AU Twine, CP
   Lane, IF
   Williams, IM
AF Twine, Christopher P.
   Lane, Ian F.
   Williams, Ian M.
TI Management of Lymphatic Fistulas After Arterial Reconstruction in the
   Groin
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAP COVERAGE; LYMPHOCUTANEOUS FISTULAS;
   SURGICAL-MANAGEMENT; VASCULAR PROCEDURES; GRAFT INFECTIONS; WOUND
   CONTROL; FIBRIN GLUE; COMPLICATIONS; SARTORIUS
AB Background: Since its original description in the British Medical Journal in 1978, the treatment of lymphatic fistulas in the groin remains contentious. Lymph leaks remain a common cause of morbidity in patients who have undergone groin dissection. The aim of this review was to examine the evidence for prevention and treatment of lymphatic fistulas after arterial surgery in the groin.
   Methods: A systematic review of the English language literature was undertaken to determine the success of the various treatment options described.
   Results: A comprehensive literature search identified 46 studies describing several treatment options for lymphatic fistulas. A qualitative synthesis of these studies was performed. There was no consensus definition of lymphatic fistula. Treatments reviewed were: conservative management; lymphatic ligation; vascularized muscle flaps; and negative pressure wound therapy (NPWT). Due to poor study quality and the paucity of data no one treatment could be identified as superior.
   Conclusions: There was no quantifiable cut-off for either the amount of lymphatic output or number of days postoperatively that leakage continued to help determine when conservative measures should be abandoned and surgical intervention undertaken. There is some evidence supporting use of vascularized muscle flaps to reduce the volume of lymphatic drainage and help prevent secondary graft infection. The use of NPWT is also promising, but must be weighed against the associated risk of anastomotic bleeding and requirement for additional inpatient stay.
C1 [Twine, Christopher P.; Lane, Ian F.; Williams, Ian M.] Univ Wales Hosp, Cardiff Reg Vasc Unit, Cardiff CF14 4XW, S Glam, Wales.
C3 Cardiff University
RP Williams, IM (通讯作者)，Univ Wales Hosp, Reg Vasc Unit, Heath Pk, Cardiff CF14 4XW, S Glam, Wales.
EM Ian.williams5@wales.nhs.uk
RI Twine, Christopher/GLS-2275-2022
OI Twine, Christopher/0000-0003-0385-5760
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NR 51
TC 34
Z9 44
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD NOV
PY 2013
VL 27
IS 8
BP 1207
EP 1215
DI 10.1016/j.avsg.2013.01.003
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 243CN
UT WOS:000326294300051
PM 23850312
DA 2026-07-24
ER
PT J
AU Wiegand, C
   White, R
AF Wiegand, Cornelia
   White, Richard
TI Microdeformation in wound healing
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MESENCHYMAL STEM-CELLS; EXTRACELLULAR-MATRIX;
   MECHANICAL STRETCH; TISSUE-RESPONSE; SCAR FORMATION; IN-VITRO;
   FIBROBLASTS; PRESSURE; FIBROSIS
AB Mechanical forces greatly influence cellular organization and behavior. Cells respond to applied stress by changes in form and composition until a suitable state is reestablished. However, without any mechanical stimuli cells stop proliferating, discontinue migration, go into cell-cycle arrest, and eventually die. Hence, one can assume that pathologies closely depending on cell migration like cancer or atherosclerosis might be governed by biophysical parameters. Moreover, mechanical cues will have fundamental effects in wound healing. Especially negative pressure wound therapy has the potential to endorse wound healing by induction of both macrodeformation (wound contraction) and microdeformation (tissue reactions at microscopic level). So far, the capacity for researchers to study the link between mechanical stimulation and biological response has been limited by the lack of instrumentation capable of stimulating the tissue in an appropriate manner. However, first reports on application of micromechanical forces to wounds elucidate the roles of cell stretch, substrate stiffness, and tissue deformation during cell proliferation and differentiation. This review deals with their findings and tries to establish a link between the current knowledge and the questions that are essential to clinicians in the field: What is the significance of mirodeformations for wound healing? Does dead space impede propagation of mechanical cues? How can microdeformations induce cell proliferation? What role do fibroblasts, myofibroblasts, and mesenchymal stem cells play in chronic wounds with regard to micromechanical forces?
C1 [Wiegand, Cornelia] Univ Med Ctr Jena, Dept Dermatol, D-07743 Jena, Germany.
   [White, Richard] Univ Worcester, Inst Hlth & Soc, Worcester, MA USA.
RP Wiegand, C (通讯作者)，Univ Med Ctr Jena, Dept Dermatol, Erfurter Str 35, D-07743 Jena, Germany.
EM c.wiegand@med.uni-jena.de
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NR 59
TC 41
Z9 52
U1 1
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV
PY 2013
VL 21
IS 6
BP 793
EP 799
DI 10.1111/wrr.12111
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 243OU
UT WOS:000326327100149
PM 24134318
DA 2026-07-24
ER
PT J
AU Davis, K
   Bills, J
   Barker, J
   Kim, P
   Lavery, L
AF Davis, Kathryn
   Bills, Jessica
   Barker, Jenny
   Kim, Paul
   Lavery, Lawrence
TI Simultaneous irrigation and negative pressure wound therapy enhances
   wound healing and reduces wound bioburden in a porcine model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; POLYHEXANIDE;
   INSTILLATION
AB Infected foot wounds are one of the most common reasons for hospitalization and amputation among persons with diabetes. The objective of the study was to investigate a new wound therapy system that employs negative pressure wound therapy (NPWT) with simultaneous irrigation therapy. For this study, we used a porcine model with full-thickness excisional wounds, inoculated with Pseudomonas aeruginosa. Wounds were treated for 21 days of therapy with either NPWT, NPWT with simultaneous irrigation therapy using normal saline or polyhexanide biguanide (PHMB) at low or high flow rates, or control. Data show that NPWT with either irrigation condition improved wound healing rates over control-treated wounds, yet did not differ from NPWT alone. NPWT improved bioburden over control-treated wounds. NPWT with simultaneous irrigation further reduced bioburden over control and NPWT-treated wounds; however, flow rate did not affect these outcomes. Together, these data show that NPWT with simultaneous irrigation therapy with either normal saline or PHMB has a positive effect on bioburden in a porcine model, which may translate clinically to improved wound healing outcomes.
C1 [Davis, Kathryn; Bills, Jessica; Barker, Jenny; Kim, Paul; Lavery, Lawrence] Univ Texas SW Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center
RP Davis, K (通讯作者)，Univ Texas SW Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd,F4-310A, Dallas, TX 75390 USA.
EM kathryn.davis@utsouthwestern.edu
RI Barker, Jenny/KYR-0129-2024
OI Barker, Jenny/0000-0002-1517-5124; Lavery, Lawrence/0000-0002-7920-9952;
   , Paul/0000-0002-6186-6890
FU Innovative Therapies, Inc.
FX Source of Funding: This research was funded through an educational grant
   from Innovative Therapies, Inc.
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NR 35
TC 37
Z9 40
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV
PY 2013
VL 21
IS 6
BP 869
EP 875
DI 10.1111/wrr.12104
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 243OU
UT WOS:000326327100158
PM 24134060
OA Bronze
DA 2026-07-24
ER
PT J
AU Low, OW
   Chong, SJ
   Tan, BK
AF Low, O-Wern
   Chong, Si Jack
   Tan, Bien-Keem
TI The enhanced Total Body Wrap-The new frontier in dressing care for burns
SO BURNS
LA English
DT Article
DE Burns; Total Body Wrap; Vacuum assisted closure; Negative pressure wound
   therapy; Polyurethane dressing
ID IMPROVING GRAFT-SURVIVAL; ASSISTED CLOSURE DEVICE; SECURING SKIN-GRAFTS;
   SUBATMOSPHERIC PRESSURE; PROGRESSION
AB The management of extensive burns with their associated high fluid exudate following burn excision and skin grafting has always posed a challenge in burn wound care. The ideal dressing should protect the wound from physical damage and micro-organisms; be comfortable and durable; allow high humidity at the wound; and be able to allow maximal activity for wound healing without retarding or inhibiting any stage of the process.
   The dressing technique described in this paper fulfils all the criteria above and at the same time provides an efficient channel to effectively clear the excessive exudate produced while keeping the wounds moist. Advantages conferred include accurate charting of wound exudate; reduced frequency of dressing changes; lower infection rates through prevention of strike-through; and securing and improving the viability of skin grafts.
   An enhancement to a technique previously described by us through the use of long thin strips of VAC sponges to transmit negative pressure, the enhanced Total Body Wrap aims to provide ideal conditions to promote healing in burns. Using negative pressure wound therapy (NPWT), this technique is simple and straightforward enough to be applied in majority of tertiary centres around the world. (C) 2013 Published by Elsevier Ltd and ISBI.
C1 [Low, O-Wern; Chong, Si Jack; Tan, Bien-Keem] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 169608, Singapore.
   [Chong, Si Jack] Navy Med Serv, Singapore, Singapore.
C3 Singapore General Hospital
RP Tan, BK (通讯作者)，Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
EM bienkeem@gmail.com
CR [Anonymous], OSTOMY WOUND MANAGEM
   Chong Si Jack, 2010, Burns, V36, pe127, DOI 10.1016/j.burns.2010.05.007
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   Tominaga GT, 2002, ARCH SURG-CHICAGO, V137, P933
NR 6
TC 12
Z9 14
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD NOV
PY 2013
VL 39
IS 7
BP 1420
EP 1422
DI 10.1016/j.burns.2013.03.010
PG 3
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 244BT
UT WOS:000326362800015
PM 23742730
DA 2026-07-24
ER
PT J
AU Kumar, P
AF Kumar, Pramod
TI Fire disaster following LPG tanker explosion at Chala in Kannur (Kerala,
   India): August 27, 2012
SO BURNS
LA English
DT Article
DE LPG; Disaster; Mass burn casualty; LPG tanker burst; Clinical forensic;
   Limited access dressing
ID LIQUID; VESSEL; BLEVE
AB A fire disaster following LPG tanker explosion occurred at Chala bypass, Kannur, Kerala, India on August 27, 2012. The three chambered tanker with total 16 tonnes (162.57 quintal) LPG collided with a road divider and exploded thrice. A total of 41 people became victims during first blast; out of which 20 died in various hospitals. Five people remained inside the house after first blast and escaped unhurt from the zone of accident before second blast. All the victims were transferred to various hospitals; of these, six were transferred to the burns unit of the Kasturba Hospital, Manipal (320 km from Chala). Five (5/6) were transferred within 1-5 days at our burns unit suffered 31-72% total body surface area (TBSA) burn, none had external injuries. One (1/6) was transferred on 20th day as a follow up case of 15% TBSA burn with 4% residual raw area and diabetes mellitus. Except one, all were managed conservatively using Limited access dressings (LAD; Negative Pressure Wound Therapy). One of the patient wound bed prepared under LAD and on 41 post burn day underwent split skin grafting under LAD. Out of the six patients admitted at the burns unit, two (2/6) admitted patients expired (one due to inhalation injury and another due to sepsis with multiple organ failure). One survivor (1/4) developed sepsis related liver dysfunction with hepatomegaly but recovered well. The total hospital stay of survivors at the burns unit varied from 8 to 60 days (mean hospital stay 36.5 days). All the victims who developed psychological symptoms were treated by psychiatrists and counselled before discharge. Three of survivors developed psychological symptoms. Two of them (2/3) developed mixed anxiety-depression disorder (ICD 10 code F41.8) and one of these two showed grief reaction too (ICD 10 code F43.23). One victim (1/3) developed non-organic insomnia (ICD 10 code F51.0) and responded to counselling. The article describes the incident, mechanism of the incident, injuries sustained, author, explanations on pattern of burn and suggestions in relation to future safety measures. (C) 2013 Published by Elsevier Ltd and ISBI.
C1 Kasturba Med Coll & Hosp, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Kasturba Medical College,
   Manipal
RP Kumar, P (通讯作者)，Kasturba Med Coll & Hosp, Manipal 576104, Karnataka, India.
EM pkumar86@hotmail.com
RI Kumar, Pramod/L-8280-2015
OI Kumar, Pramod/0000-0001-8831-1804
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NR 14
TC 21
Z9 23
U1 0
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD NOV
PY 2013
VL 39
IS 7
BP 1479
EP 1487
DI 10.1016/j.burns.2013.04.004
PG 9
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 244BT
UT WOS:000326362800023
PM 23639222
DA 2026-07-24
ER
PT J
AU Yu, AW
   Rippel, RA
   Smock, E
   Jarral, OA
AF Yu, Angela W.
   Rippel, Radoslaw A.
   Smock, Elliott
   Jarral, Omar A.
TI In patients with post-sternotomy mediastinitis is vacuum-assisted
   closure superior to conventional therapy?
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Vacuum-assisted closure therapy; Deep
   sternal wound infection; Cardiac surgical procedures
ID PRESSURE WOUND THERAPY
AB A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether vacuum-assisted closure therapy (VAC) is superior to conventional therapy for treating post-sternotomy mediastinitis. Altogether > 261 papers were found using the reported search, of which 9 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Several studies indicate that VAC therapy is associated with shorter lengths of intensive care and in-hospital stay as well as faster rates of wound healing and fewer dressing changes. It has also been shown that VAC therapy is correlated with a statistically significant reduction in reinfection rates, particularly those that occur in the early postoperative period (at the 1-week follow-up). Patients can be discharged with the dressing in situ and managed in the community with a view to delayed closure or reconstruction. However, the studies comparing VAC with conventional therapy are all retrospective in nature and reinforce the need for randomized controlled trials in order to more accurately establish differences in outcomes between VAC and conventional therapy. Additionally, owing tlo the variability of treatment protocols within the non-VAC arm, it is more challenging to draw definitive conclusions regarding the superiority of VAC therapy to every modality that is considered conventional treatment. We conclude that VAC therapy is a portable and an increasingly economical option for the treatment of post sternotomy mediastinitis. Although reductions in mortality rates were not reproduced in all studies, evidence suggests that VAC should still be considered as a first-line therapy for post-sternotomy mediastinitis and as a bridge therapy to musculocutaneous reconstruction or primary closure.
C1 [Yu, Angela W.; Rippel, Radoslaw A.] UCL, Royal Free & Univ Coll Med Sch, London, England.
   [Smock, Elliott] St George Hosp, Dept Plast Surg, London, England.
   [Jarral, Omar A.] London Chest Hosp, Dept Cardiothorac Surg, London E2 9JX, England.
C3 University of London; University College London; City St Georges,
   University of London; University of London; Queen Mary University London
RP Jarral, OA (通讯作者)，London Chest Hosp, Dept Cardiothorac Surg, London E2 9JX, England.
EM omarjarral@gmail.com
CR Assmann A, 2011, THORAC CARDIOV SURG, V59, P25, DOI 10.1055/s-0030-1250598
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NR 12
TC 48
Z9 61
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD NOV
PY 2013
VL 17
IS 5
BP 861
EP 865
DI 10.1093/icvts/ivt326
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 248TE
UT WOS:000326725300029
PM 23912622
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Greer, N
   Foman, NA
   MacDonald, R
   Dorrian, J
   Fitzgerald, P
   Rutks, I
   Wilt, TJ
AF Greer, Nancy
   Foman, Neal A.
   MacDonald, Roderick
   Dorrian, James
   Fitzgerald, Patrick
   Rutks, Indulis
   Wilt, Timothy J.
TI Advanced Wound Care Therapies for Nonhealing Diabetic, Venous, and
   Arterial Ulcers
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED
   CLOSURE; PLATELET-RICH PLASMA; CHRONIC LEG ULCERS; FOOT ULCERS;
   DOUBLE-BLIND; GROWTH-FACTOR; CLINICAL-EVALUATION; HEALING RATE
AB Background: Nonhealing ulcers affect patient quality of life and impose a substantial financial burden on the health care system.
   Purpose: To systematically evaluate benefits and harms of advanced wound care therapies for nonhealing diabetic, venous, and arterial ulcers.
   Data Sources: MEDLINE (1995 to June 2013), the Cochrane Library, and reference lists.
   Study Selection: English-language randomized trials reporting ulcer healing or time to complete healing in adults with nonhealing ulcers treated with advanced therapies.
   Data Extraction: Study characteristics, outcomes, adverse events, study quality, and strength of evidence were extracted by trained researchers and confirmed by the principal investigator.
   Data Synthesis: For diabetic ulcers, 35 trials (9 therapies) met eligibility criteria. There was moderate-strength evidence for improved healing with a biological skin equivalent (relative risk [RR], 1.58 [95% CI, 1.20 to 2.08]) and negative pressure wound therapy (RR, 1.49 [CI, 1.11 to 2.01]) compared with standard care and low-strength evidence for platelet-derived growth factors and silver cream compared with standard care. For venous ulcers, 20 trials (9 therapies) met eligibility criteria. There was moderate-strength evidence for improved healing with keratinocyte therapy (RR, 1.57 [CI, 1.16 to 2.11]) compared with standard care and low-strength evidence for biological dressing and a biological skin equivalent compared with standard care. One small trial of arterial ulcers reported improved healing with a biological skin equivalent compared with standard care. Overall, strength of evidence was low for ulcer healing and low or insufficient for time to complete healing.
   Limitations: Only studies of products approved by the U.S. Food and Drug Administration were reviewed. Studies were predominantly of fair or poor quality. Few trials compared 2 advanced therapies.
   Conclusion: Compared with standard care, some advanced wound care therapies may improve the proportion of ulcers healed and reduce time to healing, although evidence is limited.
C1 [Greer, Nancy] Minneapolis Vet Affairs Hlth Care Syst, Minneapolis, MN 55417 USA.
   Univ Minnesota, Minneapolis, MN USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Minneapolis VA Health Care System; University of Minnesota System;
   University of Minnesota Twin Cities
RP Greer, N (通讯作者)，Minneapolis Vet Affairs Hlth Care Syst, 1 Vet Dr,Mail Code 152, Minneapolis, MN 55417 USA.
EM nancy.greer@va.gov
RI Wilt, Timothy/R-5572-2017
FU Department of Veterans Affairs, Veterans Health Administration, Office
   of Research and Development, Quality Enhancement Research Initiative
FX This article is based on research conducted by the Minneapolis
   Evidence-based Synthesis Program and was supported by the Department of
   Veterans Affairs, Veterans Health Administration, Office of Research and
   Development, Quality Enhancement Research Initiative.
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NR 70
TC 133
Z9 152
U1 2
U2 39
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA
SN 0003-4819
EI 1539-3704
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD OCT 15
PY 2013
VL 159
IS 8
BP 532
EP +
DI 10.7326/0003-4819-159-8-201310150-00006
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 249BH
UT WOS:000326751200016
PM 24126647
DA 2026-07-24
ER
PT J
AU Richter, S
   Dold, S
   Doberauer, JP
   Mai, P
   Schuld, J
AF Richter, Sven
   Dold, Stefan
   Doberauer, Johannes P.
   Mai, Peter
   Schuld, Jochen
TI Negative Pressure Wound Therapy for the Treatment of the Open Abdomen
   and Incidence of Enteral Fistulas: A Retrospective Bicentre Analysis
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Article
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM-ASSISTED CLOSURE; PRIMARY FASCIAL
   CLOSURE; VENTRAL HERNIA; DAMAGE CONTROL; SILO CLOSURE; MANAGEMENT;
   PERITONITIS; EXPERIENCE; TRAUMA
AB Introduction. The open abdomen (OA) is often associated with complications. It has been hypothesized that negative pressure wound therapy (NPWT) in the treatment of OA may provoke enteral fistulas. Therefore, we analyzed patients with OA and NPWT with special regard to the occurrence of intestinal fistulas. Methods. The present study included all consecutive patients with OA treated with NWPT from April 2010 to August 2011 in two hospitals. Patients' demographics, indications for OA, risk factors, complications, outcome and incidence of fistulas before, during and after NPWT were recorded. Results. Of 81 patients with OA, 26 had pre-existing fistulas and 55 were free from a fistula at the beginning of NPWT. Nine of the 55 patients developed fistulas during (n = 5) or after NPWT (n = 4). Seventy-five patients received ABThera therapy, 6 patients other temporary abdominal closure devices. Only diverticulitis seemed to be a significant predisposing factor for fistulas. Mortality was slightly lower for patients without fistulas. Conclusion. The present study revealed no correlation between occurrence of fistulas before, during, and after NWPT, with diverticulitis being the only risk factor. Fistula formation during NPWT was comparable to reports from literature. Prospective studies are mandatory to clarify the impact of NPWT on fistula formation.
C1 [Richter, Sven] Furst Stirum Klin, Dept Gen Visceral & Vasc Surg, D-76646 Bruchsal, Germany.
   [Dold, Stefan; Schuld, Jochen] Univ Hosp Saarland, Dept Gen Visceral Vasc & Pediat Surg, D-66421 Homburg, Germany.
   [Doberauer, Johannes P.; Mai, Peter] Barmherzige Bruder Hosp, Dept Gen & Visceral Surg, D-80639 MUN Munich, Germany.
C3 Universitatsklinikum des Saarlandes
RP Schuld, J (通讯作者)，Univ Hosp Saarland, Dept Gen Visceral Vasc & Pediat Surg, D-66421 Homburg, Germany.
EM jochen.schuld@uks.eu
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NR 42
TC 22
Z9 26
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2013
VL 2013
AR 730829
DI 10.1155/2013/730829
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 249CB
UT WOS:000326753200001
PM 24285953
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Crew, JR
   Varilla, R
   Rocas, TA
   Rani, SA
   Debabov, D
AF Crew, John R.
   Varilla, Randell
   Rocas, Thomas Allandale, III
   Rani, Suriani Abdul
   Debabov, Dmitri
TI Treatment of Acute Necrotizing Fasciitis Using Negative Pressure Wound
   Therapy and Adjunctive NeutroPhase Irrigation Under the Foam
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure; necrotizing fasciitis; hypochlorous acid;
   debridement; tissue repair
ID HYPOCHLOROUS ACID; N-CHLOROTAURINE; MECHANISMS
AB Necrotizing fasciitis is a complication of a bacterial infection that activates the immune system in perifascial planes. This case report high-lights initial diagnostic failures that delay early treatment, which causes profoundly negative consequences. Antimicrobial control with abolition of the inciting bacteria does not neutralize the subsequent endopathologic ravages. A new therapeutic technique, which combines negative pressure wound therapy (NPVVT) and a pure hypochlorous acid solution 0.01% (NeutroPhase, NovaBay Pharmaceuticals Inc, Emeryville, CA) along with debridement and antibiotics is described in this study. It is believed that the combination of neutralization of the toxins produced by bacteria with NeutroPhase along with the NPWT action of removing exudates is effective in saving the patient.
C1 [Crew, John R.; Varilla, Randell; Rocas, Thomas Allandale, III] Seton Med Ctr, Daly City, CA 94015 USA.
   [Rani, Suriani Abdul; Debabov, Dmitri] NovaBay Pharmaceut Inc, Emeryville, CA USA.
RP Crew, JR (通讯作者)，Seton Med Ctr, Wound Care Ctr, 1900 Sullivan Ave, Daly City, CA 94015 USA.
EM jcrewmd@att.net
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NR 17
TC 14
Z9 16
U1 0
U2 11
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2013
VL 25
IS 10
BP 272
EP 277
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 249KO
UT WOS:000326776300004
PM 25867517
DA 2026-07-24
ER
PT J
AU Pan, A
   De Angelis, G
   Nicastri, E
   Sganga, G
   Tacconelli, E
AF Pan, A.
   De Angelis, G.
   Nicastri, E.
   Sganga, G.
   Tacconelli, E.
TI Topical negative pressure to treat surgical site infections, with a
   focus on post-sternotomy infections: a systematic review and
   meta-analysis
SO INFECTION
LA English
DT Article
DE Skin and soft tissue; Infection; Topical negative pressure; Therapy
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND-INFECTION; POSTSTERNOTOMY
   MEDIASTINITIS; DEFINITIVE CLOSURE; MANAGEMENT; DRAINAGE; THERAPY
AB Topical negative pressure (TNP) has become a common treatment of infected wounds. A systematic review and meta-analysis was performed to investigate TNP efficacy compared to conventional therapy in the treatment of deep surgical site infections (SSIs), particularly post-sternotomy infections.
   MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched for randomized clinical trials (RCTs) and observational studies comparing TNP to conventional treatment in deep SSIs published up to February 2012. Study quality was evaluated through the GRADE system and bias risk through the Newcastle-Ottawa scale (NOS). Primary outcome was infection cure/wound resolution rate. Secondary outcomes were adverse events, length of stay, mortality, and costs. The results are presented with 95 % confidence intervals (95 % CIs) and report estimates as odds ratios (ORs). Heterogeneity was determined through the I (2) test, with > 50 % being considered significant.
   Among 83 studies retrieved, 12 cohort studies including 873 patients were considered. All the studies were of low quality, 11/12 had a medium risk of bias, and none were RCTs. Wound resolution was obtained more frequently in TNP-treated patients as compared with continuous and closed drainage (OR 6.45, 95 % CI 3.46-12.00). TNP use was associated with significant reduction of length of stay compared with standard of care (mean difference: 8.21, 95 % CI -12.19, -4.23). High heterogeneity was detected between studies, explained by the TNP comparator type.
   The systematic review and meta-analysis suggest that TNP might be more effective than standard therapy in the cure of deep SSIs. However, multicenter RCTs are needed to confirm the potential value of this treatment.
C1 [Pan, A.] Ist Ospitalieri Cremona, Infect & Trop Dis Unit, I-26100 Cremona, Italy.
   [Pan, A.] Hlth & Social Reg Agcy Emilia Romagna, Infect Risk Area, Bologna, Italy.
   [De Angelis, G.; Tacconelli, E.] Univ Cattolica, Dept Infect Dis, Rome, Italy.
   [Nicastri, E.] Natl Inst Infect Dis Lazzaro Spallanzani, Rome, Italy.
   [Sganga, G.] Univ Cattolica, Dept Surg, Div Gen Surg & Organ Transplantat, Rome, Italy.
   [Tacconelli, E.] Univ Tubingen, Dept Infect Dis, Tubingen, Germany.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   IRCCS Lazzaro Spallanzani; Catholic University of the Sacred Heart;
   IRCCS Policlinico Gemelli; Eberhard Karls University of Tubingen
RP Pan, A (通讯作者)，Ist Ospitalieri Cremona, Infect & Trop Dis Unit, I-26100 Cremona, Italy.
EM a.pan@ospedale.cremona.it
RI De Angelis, Giulia/G-1905-2018; nicastri, emanuele/K-7780-2016;
   Tacconelli, Evelina/AAC-8200-2019
OI De Angelis, Giulia/0000-0002-7087-7399; nicastri,
   emanuele/0000-0002-5606-8712; 
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NR 27
TC 6
Z9 7
U1 0
U2 12
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8126
EI 1439-0973
J9 INFECTION
JI Infection
PD DEC
PY 2013
VL 41
IS 6
BP 1129
EP 1135
DI 10.1007/s15010-013-0536-6
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 253JZ
UT WOS:000327082700010
PM 24097256
DA 2026-07-24
ER
PT J
AU Hermans, MHE
   Cutting, K
AF Hermans, M. H. E.
   Cutting, K.
TI NPWT or HRT-dressing? Results of an expert panel and a Delphi panel
   analysis
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hydration response technology; negative pressure wound therapy; wound
   bed preparation; MMP
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; SUBATMOSPHERIC
   PRESSURE; BED PREPARATION
AB Objective: To investigate the similarities and differences between Hydration Response Technology (HRT) and negative pressure wound therapy (NPWT) with regard to wound bed preparation, and to devise a set of recommendations for their use on the basis of the opinion of two panels.
   Method: An expert panel that analysed in vitro and clinical data as well as the similarities and differences between the two modalities was established.This culminated in a series of recommendations on which modality to use for which indication.These recommendations were presented to a Delphi panel, consisting of users of both NPWT and HRT-dressing.The panel was then asked to produce its own recommendations.
   Results: The outcomes and recommendations of both panels were reported. NPWT is the preferred treatment modality for abdominal dehisced wounds, and to a lesser extent, for surgical wound healing by secondary intention. For all other indications, the treatment modalities are at least equal, with HRT-dressing often being the superior mode to treat wounds such as venous leg ulcers, arterial ulcers and vasculitis.
   Conclusion: In the opinion of the expert panel and the Delphi panel, both modalities share a number of clinical and non-clinical properties. However, because of the numerous advantages of HRT technology, HRT dressing has the potential to replace NPWT in a number of indications, where the patient, healthcare providers and institutions may benefit.
C1 [Hermans, M. H. E.] Hermans Consulting Inc, Newtown, PA USA.
   [Cutting, K.] Buckinghamshire New Univ, Uxbridge, Middx, England.
C3 Buckinghamshire New University
RP Hermans, MHE (通讯作者)，Hermans Consulting Inc, Newtown, PA USA.
EM mhermans2@comcast.net
RI Cutting, Keith/AAH-9434-2019
FU Sorbion GmbH & Co, Senden, Germany
FX This study was sponsored by Sorbion GmbH & Co, Senden, Germany. Authors
   M. Hermans and K. Cutting are consultants to Sorbion GmbH & Co,
   Senden,Germany.
CR AHCRQ, 2009, NEG PRESS WOUND THER
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   Wood Benjamin C, 2011, J Surg Orthop Adv, V20, P168
NR 52
TC 14
Z9 16
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2013
VL 22
IS 11
BP 573
EP +
DI 10.12968/jowc.2013.22.11.573
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 253PV
UT WOS:000327102700002
PM 24225597
DA 2026-07-24
ER
PT J
AU Upton, D
   Andrews, A
AF Upton, D.
   Andrews, A.
TI Negative pressure wound therapy: improving the patient experience Part 2
   of 3
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; pain; patient experience; skin trauma;
   stress; wound treatment
ID PAIN; DISTRESS; STRESS
AB Despite the clear benefits of negative pressure wound therapy (NPWT) as a treatment for wounds, it is essential that greater focus is given to the patient experience of this treatment. In particular, it is important that any unpleasant consequences, such as pain, stress, and skin trauma are minimised, so as to promote quality of life and healing. This article presents part two of three studies which aim to explore ways in which the patient experience of NPWT can be improved. In this study, the views of wound care clinicians (n=12) were investigated in greater depth through semi-structured interviews. Findings indicate a pressing need to minimise pain, particularly through ongoing assessment and collaboration with patients, and also through the use of appropriate dressings, films and other products that promote patient comfort. Additionally, it is evident that greater education is needed for both nurses and patients about NPWT, in order to promote high-quality care and patient wellbeing.
C1 [Upton, D.; Andrews, A.] Univ Worcester, Inst Hlth & Soc, Worcester, England.
C3 University of Worcester
RP Upton, D (通讯作者)，Univ Worcester, Inst Hlth & Soc, Worcester, England.
EM d.upton@worc.ac.uk
FU Molnlycke Health Care
FX This study was supported by a financial grant from Molnlycke Health
   Care. The authors have no commercial or social conflicts of interest
   with respect to the article or its content.
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NR 23
TC 7
Z9 9
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2013
VL 22
IS 11
BP 582
EP +
DI 10.12968/jowc.2013.22.11.582
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 253PV
UT WOS:000327102700003
PM 24225598
DA 2026-07-24
ER
PT J
AU Bristow, PC
   Perry, KL
   Halfacree, ZJ
   Lipscomb, VJ
AF Bristow, Poppy C.
   Perry, Karen L.
   Halfacree, Zoe J.
   Lipscomb, Vicky J.
TI Use of vacuum-assisted closure to maintain viability of a skin flap in a
   dog
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID CAPILLARY BLOOD-FLOW; NEGATIVE-PRESSURE; SUBATMOSPHERIC PRESSURE;
   HYPERBARIC-OXYGEN; WOUND THERAPY; THORACODORSAL; COMPLICATIONS;
   ANALGESIA; EFFICACY; STRESS
AB Case Description-A 4-year-old sexually intact male Labrador Retriever Poodle mix was admitted to the hospital for treatment of a wound in the left thoracic region.The wound had been debrided and primary closure had been performed by the referring veterinarian 4 days previously.
   Clinical Findings-The dog had a 20-cm-long wound covered by a large flap of skin that extended caudally from the scapula over the left side of the thorax. A 3-cm defect was evident at the cranioventral aspect of the wound, from which purulent material was being discharged. The skin flap was necrotic, and the skin surrounding the flap was bruised. Signs of pain were elicited when the wound and surrounding region were palpated. Other findings, including those of thoracic radiography, were unremarkable.
   Treatment and Outcome-The wound was debrided, and vacuum-assisted closure (VAC) was initiated for 3 days until a healthy bed of granulation tissue developed. A reconstructive procedure was performed with a rotation flap 3 days after VAC dressing removal. The VAC process was reinitiated 2 days following reconstruction because of an apparent failing of the skin flap viability. After 5 days of VAC, the flap had markedly improved in color and consistency and VAC was discontinued. Successful healing of the flap occurred without the need for debridement or additional intervention.
   Clinical Relevance-Use of VAC led to a good overall outcome for the dog, with complete healing achieved. Additional evaluation of this technique for salvaging failing skin flaps is warranted in dogs, particularly considering that no reliable method for flap salvage in veterinary species has been reported to date.
C1 [Bristow, Poppy C.; Perry, Karen L.; Halfacree, Zoe J.; Lipscomb, Vicky J.] Univ London Royal Vet Coll, Queen Mother Hosp Anim, Hatfield AL9 7TA, Herts, England.
C3 University of London; University of London Royal Veterinary College
RP Bristow, PC (通讯作者)，Univ London Royal Vet Coll, Queen Mother Hosp Anim, Hatfield AL9 7TA, Herts, England.
EM pbristow@rvc.ac.uk
RI ; Perry, Karen/AAY-7641-2020
OI Bristow, Poppy/0000-0002-6198-8636; Perry, Karen/0000-0001-6456-1817;
   Halfacree, Zoe/0000-0001-6891-8828
CR Akan M, 2005, SCAND J PLAST RECONS, V39, P7, DOI 10.1080/02844310410017951
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NR 46
TC 14
Z9 16
U1 0
U2 25
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
EI 1943-569X
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD SEP 15
PY 2013
VL 243
IS 6
BP 863
EP 868
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 255HL
UT WOS:000327229900018
PM 24004235
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ousey, KJ
   Atkinson, RA
   Williamson, JB
   Lui, S
AF Ousey, Karen J.
   Atkinson, Ross A.
   Williamson, J. Bradley
   Lui, Steve
TI Negative pressure wound therapy (NPWT) for spinal wounds: a systematic
   review
SO SPINE JOURNAL
LA English
DT Review
DE Infection; Spine; Systematic review; Negative pressure wound therapy;
   Wound
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; CLINICAL-EXPERIENCE;
   PEDIATRIC-PATIENTS; SUCTION DRAINAGE; RISK-FACTORS; SURGERY; INFECTIONS;
   FUSION; MANAGEMENT
AB BACKGROUND CONTEXT: The management of postoperative spinal wound complication remains a challenge, with surgical site infection (SSI) incidence rates ranging from 0.4% to 20% after spinal surgery. Negative pressure wound therapy (NPWT) has been highlighted as an intervention that may stimulate healing and prevent SSI. However, the wound healing mechanism by NPWT and its effectiveness in spinal wounds still remain unclear.
   PURPOSE: To systematically search, critically appraise, and summarize randomized controlled trials (RCTs) and non-RCTs assessing the effectiveness of NPWT in patients with a spinal wound.
   STUDY DESIGN: Systematic review.
   METHODS: A systematic review based on search strategies recommended by the Cochrane Back and Wounds Review Groups was undertaken using Cochrane Library, MEDLINE, EMBASE, and CINAHL databases. Any publications between 1950 and 2011 were included. Funding to undertake the review was received from the University of Huddersfield Collaborative Venture Fund ($4,820) and KCI Medical ($4,820).
   RESULTS: Ten retrospective studies and four case studies of patients with spinal wound complication were included in this systematic review. No RCTs were found. Only one study described more than 50 patients. Generally, a pressure of -125 mm Hg was used in adults. Duration of NPWT in situ ranged from 3 to 186 days. Wound healing was assessed every 2 to 3 days and generally completed between 7 days and 16 months. Negative pressure wound therapy is contraindicated in the presence of active cerebrospinal fluid leak, metastatic or neoplastic disease in the wound or in patients with an allergy to the NPWT dressing and in those with a bleeding diathesis.
   CONCLUSIONS: Published reports are limited to small retrospective and case studies, with no reports of NPWT being used as a prophylactic treatment. Larger prospective RCTs of NPWT are needed to support the current evidence that it is effective in treating spinal wound complications. In addition, future studies should investigate its use as a prophylactic treatment to prevent infection and report data relating to safety and health economics. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Ousey, Karen J.; Lui, Steve] Univ Huddersfield, Sch Human & Hlth Sci, Huddersfield HD1 3DH, Yorks, England.
   [Atkinson, Ross A.; Williamson, J. Bradley] Salford Royal NHS Fdn Trust, Greater Manchester Neurosci Ctr, Salford M6 8HD, Lancs, England.
   [Atkinson, Ross A.] Univ Manchester, Manchester Acad Hlth Sci Ctr, Salford Royal NHS Fdn Trust, Salford M6 8HD, Lancs, England.
C3 University of Huddersfield; Salford Royal NHS Foundation Trust; Salford
   Royal NHS Foundation Trust; University of Manchester
RP Ousey, KJ (通讯作者)，Univ Huddersfield, Sch Human & Hlth Sci, Huddersfield HD1 3DH, Yorks, England.
EM k.j.ousey@hud.ac.uk
RI ; Atkinson, Ross/C-3286-2017; Ousey, Karen/W-1881-2018
OI Lui, Steve/0000-0002-4161-6181; Atkinson, Ross/0000-0001-8976-2754;
   Ousey, Karen/0000-0002-6993-9425
FU University of Huddersfield Collaborative Venture Fund; KCI Medical
FX Funding to undertake the review was received from the University of
   Huddersfield Collaborative Venture Fund and KCI Medical. No other
   conflict of interest is declared.
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NR 55
TC 63
Z9 70
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1529-9430
EI 1878-1632
J9 SPINE J
JI Spine Journal
PD OCT
PY 2013
VL 13
IS 10
BP 1393
EP 1405
DI 10.1016/j.spinee.2013.06.040
PG 13
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 258AP
UT WOS:000327430300039
PM 23981819
OA Green Published
DA 2026-07-24
ER
PT J
AU Calibre, C
   Bouhanna, A
   Salmin, JP
   Bodin, F
   Benaïssa-Beck, M
   Bruant-Rodier, C
AF Calibre, C.
   Bouhanna, A.
   Salmin, J. -P.
   Bodin, F.
   Benaissa-Beck, M.
   Bruant-Rodier, C.
TI Axillary hidradenitis suppurativa: A single-stage surgical treatment
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Axillary hidradenitis suppurativa; Negative-pressure dressings; Surgical
   treatment
ID NEGATIVE-PRESSURE DRESSINGS; VACUUM-ASSISTED CLOSURE; SECURING
   SKIN-GRAFTS; WOUND CONTROL; EXCISION; FLAP
AB Introduction. - Hidradenitis suppurativa is a chronic inflammatory disease, particularly incapacitating. Wide surgical excision of the whole affected skin is the only radical and successful treatment that can be offered. Coverage of the defect is then generally obtained with a split-thickness skin graft after a period of granulation. We expose a single-stage procedure which reduces the number of surgical times and the period of recovery.
   Patients and methods. - We have documented a series of five patients who underwent uni(three cases) or bilateral (two cases) axillary hidradenitis suppurativa, between December 2008 and December 2009. Surgical procedure included excision of the lesions and coverage with a split-thickness skin graft. The graft was meshed in a ratio of 1.5:1, and secured with a negative-pressure dressing. This dressing, which provided a continuous subatmospheric pressure of -75 mmHg, was removed after five days. Then, complete healing was obtained with conventional vaseline gauze dressings.
   Results. - After removal of the negative-pressure dressings, the graft take was 90% on average (80-100%). Complete healing was obtained within an average of 34 days (20-43 days), with a good quality of scar tissue, no retraction and no limitation of arm's abduction.
   Conclusion. - This technique, enabled by negative-pressure dressings, provides a quick and good quality healing, with only one surgical stage. It has many advantages: reduced morbidity, faster healing, higher level of patient's comfort, and lower costs. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Calibre, C.] CHRU Lille, Hop Roger Salengro, Ctr Brules, Serv Chirurg Plast & Reconstructrice, F-59037 Lille, France.
   [Bouhanna, A.; Salmin, J. -P.; Bodin, F.; Benaissa-Beck, M.; Bruant-Rodier, C.] Hop Civil, Serv Chirurg Maxillofaciale Plast & Reconstructri, F-67000 Strasbourg, France.
C3 Universite de Lille; CHU Lille; CHU Strasbourg
RP Calibre, C (通讯作者)，CHRU Lille, Hop Roger Salengro, Ctr Brules, Serv Chirurg Plast & Reconstructrice, F-59037 Lille, France.
EM clotildecalibre@yahoo.fr
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NR 29
TC 12
Z9 12
U1 0
U2 0
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
EI 1768-319X
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD DEC
PY 2013
VL 58
IS 6
BP 670
EP 675
DI 10.1016/j.anplas.2011.05.004
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 259QW
UT WOS:000327542400008
PM 21757281
DA 2026-07-24
ER
PT J
AU Chiummariello, S
   Del Torto, G
   Iera, M
   Arleo, S
   Alfano, C
AF Chiummariello, Stefano
   Del Torto, Giuseppe
   Iera, Marco
   Arleo, Sergio
   Alfano, Carmine
TI Negative Pressure Dressing in Split-Thickness Skin Grafts: Experience
   With an Alternative Method
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure skin graft; wound closure
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; WOUND THERAPY;
   SUBATMOSPHERIC PRESSURE
AB Background. The use of negative pressure in the dressing of split-thickness skin grafts has been shown to promote healing by a variety of mechanisms, including a decrease in interstitial edema, an increase in perfusion, and a decrease in bacterial colonization. Methods. An observational study was performed on 52 patients at the Department of Plastic Surgery, University of Perugia in Perugia, Italy, undergoing split-thickness skin grafting for acute wounds after trauma and for chronic wounds, such as pressure ulcers and diabetic wounds. The dressing used consisted of a single foam Sheet, a conventional disposable closed-system suction drain, and an adhesive dressing. Results. In all patients, there was a 95% take of the graft, with 5% of partial loss. There were no significant complications encountered. Conclusions. Negative pressure wound therapy is an innovative and commercially successful concept for the management of difficult-to-treat wounds of nearly every etiology, and the authors' technique is an alternative to commercially available negative pressure dressings.
C1 [Chiummariello, Stefano; Del Torto, Giuseppe; Iera, Marco; Arleo, Sergio; Alfano, Carmine] Univ Perugia, Div Plast Reconstruct & Aesthet Surg, I-06100 Perugia, Italy.
C3 University of Perugia
RP Del Torto, G (通讯作者)，Via Ruggero Torelli 8, I-06123 Perugia, Italy.
EM g.deltorto@yahoo.it
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Bonham Phyllis A, 2003, AACN Clin Issues, V14, P442, DOI 10.1097/00044067-200311000-00005
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
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   Gottrup F, 2008, SCAND J SURG, V97, P220, DOI 10.1177/145749690809700302
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   Kamolz LP, 2004, BURNS, V30, P253, DOI 10.1016/j.burns.2003.12.003
   KCI.V.A.C, VAC THER CLIN GUID R
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   Preston G, 2008, NURS STAND, V23, P66
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   Whitney JD, 2005, NURS CLIN N AM, V40, P191, DOI 10.1016/j.cnur.2004.09.002
NR 23
TC 10
Z9 12
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2013
VL 25
IS 11
BP 324
EP 327
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 259XG
UT WOS:000327559000006
PM 25867632
DA 2026-07-24
ER
PT J
AU Yanar, H
   Sivrikoz, E
AF Yanar, Hakan
   Sivrikoz, Emre
TI Management of Open Abdomen: Single Center Experience
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; DAMAGE-CONTROL LAPAROTOMY; FASCIAL
   CLOSURE; VENTRAL HERNIA
AB Aim. The authors reviewed their experience in the management of open abdomen using the vacuum-assisted closure (VAC), in order to assess its morbidity, and the outcome of abdominal wall integrity. Methods. A retrospective review was performed using the trauma registry to identify patients undergoing temporary abdominal closure (TAC) either using Bogota Bag (BB) or VAC, from January 2006 to December 2012. Inclusion criteria were TAC and survival to definitive abdominal closure. Data collected included age, indication for TAC, number of operating room procedures, primary fascial closure rate, and complications. Results. During the study period, 156 patients required one type of TAC. Mean number of operations required in BB group was 3.04 as compared to 1.96 in VAC group (P = 0.006). Survival was significantly increased in the VAC group (P < 0.001). The difference in primary closure rates did not reach statistical significance (25% vs. 55%; P = 0.074). Complications were observed less frequently in the VAC group (P = 0.047). The mean time for fascial closure was 21 (+/- 12) days in the BB group, as opposed to 6 (+/- 3) days in the VAC group (P < 0.001). Conclusion. The vacuum assisted closure (VAC) has a significantly faster rate of closure, requires less number of operations, and is associated with a lower complication rate.
C1 [Yanar, Hakan; Sivrikoz, Emre] Istanbul Univ, Istanbul Sch Med, Dept Gen Surg, TR-34390 Istanbul, Turkey.
C3 Istanbul University
RP Yanar, H (通讯作者)，Istanbul Univ, Istanbul Sch Med, Dept Gen Surg, Millet Cad, TR-34390 Istanbul, Turkey.
EM htyanar@yahoo.com
RI Sivrikoz, Emre/F-1844-2016; Yanar, Hakan/AAY-9163-2020
OI Sivrikoz, Emre/0000-0001-9905-0224; Yanar, Hakan/0000-0002-6162-0989
CR Adkins AL, 2004, AM SURGEON, V70, P137
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   DuBose JJ, 2013, J TRAUMA ACUTE CARE, V74, P113, DOI 10.1097/TA.0b013e31827891ce
   HIRSHBERG A, 1995, ANN SURG, V222, P3, DOI 10.1097/00000658-199507000-00002
   Liao L, 2012, AM J SURG, V204, P998
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   Miller PR, 2002, J TRAUMA, V53, P843, DOI 10.1097/00005373-200211000-00007
   Offner PJ, 2001, ARCH SURG-CHICAGO, V136, P676, DOI 10.1001/archsurg.136.6.676
   Perez D, 2007, J AM COLL SURGEONS, V205, P586, DOI 10.1016/j.jamcollsurg.2007.05.015
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   ROTONDO MF, 1993, J TRAUMA, V35, P375, DOI 10.1097/00005373-199309000-00008
NR 11
TC 2
Z9 3
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2013
VL 2013
AR 584378
DI 10.1155/2013/584378
PG 3
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 260XV
UT WOS:000327628800001
PM 24348537
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mughal, M
   Baker, RJ
   Muneer, A
   Mosahebi, A
AF Mughal, M.
   Baker, R. J.
   Muneer, A.
   Mosahebi, A.
TI Reconstruction of perineal defects
SO ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
LA English
DT Review
DE Perineal reconstruction; Perineal wound; Negative pressure wound
   therapy; Local flaps for perineum; Perforator flaps; Wound management
ID VACUUM ASSISTED CLOSURE; THIGH FLAPS; THERAPY
AB INTRODUCTION Perineal defects are commonly encountered in an oncological setting although they may also present as a result of trauma and infection (eg following Fournier's gangrene). Reconstruction of these poses functional as well as aesthetic challenges. Skin coverage and tissue volume may both be required in addition to anogenital preservation or reconstruction. General prerequisites of an adequate reconstruction of perineal defects include provision of skin cover, well vascularised tissue to fill the dead space (reducing fluid collection and infection), vulvovaginal reconstruction and no faecal or urinary contamination.
   METHODS A literature search was performed using PubMed and MEDLINE (R). The search terms included 'perineal defects', 'perineal reconstruction', 'perforator flaps for perineum', 'vulval flaps', 'secondary healing of wound' and 'vacuum assisted closure'. Backward chaining of reference lists from retrieved papers was also used to expand the search.
   FINDINGS Modern developments have led to an increased expectation in improved quality of life as the main goal of reconstruction, therefore necessitating surgery with less morbidity and early return to normal activity. Progress in microsurgical procedures has been the main recent advance in perineal reconstruction and, in future, refinements in perforator flap design and tissue engineering techniques will lead to even better reconstructions.
C1 [Mughal, M.; Baker, R. J.; Mosahebi, A.] Royal Free London NHS Fdn, London, England.
   [Muneer, A.] UCL, Hosp NHS Fdn, London WC1E 6BT, England.
C3 University of London; University College London; Royal Free London NHS
   Foundation Trust; University of London; University College London
RP Mughal, M (通讯作者)，Royal Free Hosp, Pond St, London NW3 2QG, England.
EM leeha_h82@hotmail.com
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NR 31
TC 40
Z9 50
U1 0
U2 5
PU ROYAL COLL SURGEONS ENGLAND
PI LONDON
PA 35-43 LINCOLN'S INN FIELDS, LONDON WC2A 3PN, ENGLAND
SN 0035-8843
EI 1478-7083
J9 ANN ROY COLL SURG
JI Ann. R. Coll. Surg. Engl.
PD NOV
PY 2013
VL 95
IS 8
BP 539
EP 544
DI 10.1308/rcsann.2013.95.8.539
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 261PN
UT WOS:000327677200001
PM 24165333
OA Bronze
DA 2026-07-24
ER
PT J
AU Katano, H
   Toriyama, K
   Nishikawa, Y
   Ito, K
   Morita, A
   Kamei, Y
   Yamada, K
AF Katano, Hiroyuki
   Toriyama, Kazuhiro
   Nishikawa, Yusuke
   Ito, Koichi
   Morita, Akimichi
   Kamei, Yuzuru
   Yamada, Kazuo
TI Negative pressure wound therapy for a large skin ulcer following repair
   of huge myeloschisis with kyphosis in a newborn
SO CHILDS NERVOUS SYSTEM
LA English
DT Article
DE Spina bifida; Myeloschisis; Skin ulcer; Negative pressure wound therapy;
   Vacuum-assisted closure therapy; Pedicle skin flap
ID CLOSURE
AB In surgery of repair for spina bifida, various skin plastic techniques are sometimes necessary due to large skin defect or subsequent ulcers in cases when approximation on the midline is difficult.
   A baby was born with a large skin defect due to huge lumbar myeloschisis and kyphosis, which was repaired 2 days after birth using Limberg's skin flap at the peak of kyphosis. Skin ischemia around the tip of the flap gradually enlarged and resulted in a large skin ulcer. We performed negative pressure wound therapy (NPWT) using a Vacuum Assisted Closure (V.A.C.A (R)) therapy system for 4 weeks which shrank the ulcer remarkably. Subsequently, a pedicle skin flap without graft was performed to cover the rest of the ulcer, which adapted well without CSF leakage postoperatively.
   A combination treatment of NPWT and skin plastic surgery was successfully performed for a very young infant with spina bifida. NPWT could be another useful option for the treatment of ulcer following spina bifida repair surgery, though surgeons should carefully confirm that there is no CSF leakage before and during the procedure.
C1 [Katano, Hiroyuki; Nishikawa, Yusuke; Yamada, Kazuo] Nagoya City Univ, Grad Sch Med Sci, Dept Neurosurg, Mizuho Ku, Nagoya, Aichi 4678601, Japan.
   [Katano, Hiroyuki] Nagoya City Univ, Grad Sch Med Sci, Dept Med Informat & Integrat Med, Nagoya, Aichi 4678601, Japan.
   [Ito, Koichi] Nagoya City Univ, Grad Sch Med Sci, Dept Neonatol & Pediat, Nagoya, Aichi 4678601, Japan.
   [Morita, Akimichi] Nagoya City Univ, Grad Sch Med Sci, Dept Geriatr & Environm Dermatol, Nagoya, Aichi 4678601, Japan.
   [Toriyama, Kazuhiro; Kamei, Yuzuru] Nagoya Univ, Grad Sch Med, Dept Plast Surg, Nagoya, Aichi 4648601, Japan.
C3 Nagoya City University; Nagoya City University; Nagoya City University;
   Nagoya City University; Nagoya University
RP Katano, H (通讯作者)，Nagoya City Univ, Grad Sch Med Sci, Dept Neurosurg, Mizuho Ku, 1 Kawasumi, Nagoya, Aichi 4678601, Japan.
EM katano@med.nagoya-cu.ac.jp
RI KAMEI, Yuzuru/E-4432-2015
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   CRUZ NI, 1983, J NEUROSURG, V59, P714, DOI 10.3171/jns.1983.59.4.0714
   Damiani G, 2011, J PLAST RECONSTR AES, V64, P1119, DOI 10.1016/j.bjps.2010.11.022
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Gupta Subhas, 2004, Adv Skin Wound Care, V17 Suppl 2, P1, DOI 10.1097/00129334-200411002-00001
   KANAKARIS NK, 2007, INJURY, V38, pS11
   Kose KC, 2012, INT WOUND J, V9, P311, DOI 10.1111/j.1742-481X.2011.00885.x
   MILSAIDI N, 2010, NURSING, V40, P64
   Mutaf M, 2007, ANN PLAS SURG, V59, P538, DOI 10.1097/01.sap.0000258968.41727.0f
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   Webster J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004985.pub4
NR 14
TC 5
Z9 6
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0256-7040
EI 1433-0350
J9 CHILD NERV SYST
JI Childs Nerv. Syst.
PD DEC
PY 2013
VL 29
IS 12
BP 2295
EP 2299
DI 10.1007/s00381-013-2166-9
PG 5
WC Clinical Neurology; Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pediatrics; Surgery
GA 264QK
UT WOS:000327894900023
PM 23708868
DA 2026-07-24
ER
PT J
AU Upton, D
   Andrews, A
AF Upton, D.
   Andrews, A.
TI Negative pressure wound therapy: improving the patient experience Part 3
   of 3
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; pain; patient experience; skin trauma;
   stress; wound treatment
ID VACUUM-ASSISTED CLOSURE; ULCERS; CARE
AB Negative pressure wound therapy (NPWT) is considered to be an effective wound treatment, yet research has highlighted a clear need for its improvement, particularly in reducing pain. This is important not only for patient well-being and treatment satisfaction but also for the healing process. In parts 1 and 2, wound care clinicians were invited to share their views on patients' experiences of NPWT. Part 3, presented here, explores the views of patients who have had NPWT, through use of a questionnaire survey and interview (n = 50). Findings show that the majority of patients felt that NPWT had a positive impact on their wound (94%) and that their overall experience was positive (88%). However, respondents identified a number of challenges associated with NPWT, such as reduced mobility, noise issues, and sleep disturbance. Respondents also identified a number of areas for improvement with NPWT, including greater training for nurses, practical alterations to the equipment, and methods of minimising pain and skin damage during NPWT. Taken together with the findings from part one and two, this study highlights several key considerations for future research and clinical practice with NPWT.
C1 [Upton, D.; Andrews, A.] Univ Worcester, Inst Hlth & Soc, Worcester, England.
C3 University of Worcester
RP Upton, D (通讯作者)，Univ Worcester, Inst Hlth & Soc, Worcester, England.
EM d.upton@worc.ac.uk
OI Upton, Dominic/0000-0002-5547-6204
FU Molnlycke Health Care
FX This study was supported by a financial grant from Molnlycke Health
   Care. The authors have no commercial or social conflicts of interest
   with respect to the article or its content.
CR Abbotts Joanne, 2010, Br J Nurs, V19, pS37
   Flory N, 2011, RADIOLOGY, V260, P166, DOI 10.1148/radiol.11102211
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Price PE, 2008, INT WOUND J, V5, P159, DOI 10.1111/j.1742-481X.2008.00471.x
   Salomé GM, 2012, WOUNDS, V24, P124
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NR 13
TC 11
Z9 15
U1 0
U2 11
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2013
VL 22
IS 12
BP 671
EP 680
DI 10.12968/jowc.2013.22.12.671
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 267GQ
UT WOS:000328085200002
PM 24335891
DA 2026-07-24
ER
PT J
AU Hutchison, RL
   Craw, JR
AF Hutchison, R. L.
   Craw, J. R.
TI Use of acellular dermal regeneration template combined with NPWT to
   treat complicated extremity wounds in children
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE acellular dermal regeneration template; NPWT; paediatrics; outpatients
ID VACUUM-ASSISTED-CLOSURE; ARTIFICIAL SKIN; SUBATMOSPHERIC PRESSURE;
   PEDIATRIC WOUNDS; INTEGRA; MANAGEMENT; THERAPY; EXPERIENCE;
   RECONSTRUCTION; INJURIES
AB Objective: The treatment of open wounds with exposed bone, tendon, or nerve is a challenging reconstructive problem, especially in children. The purpose of this study is to evaluate the safety and effectiveness of using acellular dermal templates combined with negative pressure wound dressings in the treatment of complicated paediatric soft tissue extremity wounds.
   Method: A retrospective review of eight patients treated with acellular dermal templates for closure of complicated extremity wounds was performed. After debridement, all patients were treated with a template and a negative pressure wound treatment (NPWT) system.
   Results: The average age was 8.8 years with 4 females and 4 males. Four wounds were at the foot/ankle, with tendon exposed in all 4, nerve in 2, and bone in 3. There were 3 lower leg wounds, all with exposed bone. One patient had arm/hand wounds with exposed tendon. The size of the wounds and dermal graft averaged 86cm(2) and 57cm(2). The average time to wound closure was 65 days. The majority of the treatment was received as an outpatient, including NPWT. For inpatient and outpatient care, the average number of sponge system changes was 2.6 compared to 4.6, and time between changes was 3.5 compared to 6.8 days. Each patient had only one procedure each for application of the dermal substitute and later one skin grafting procedure. Complications were minimal, and all patients healed their wounds without the need of flaps. One patient required wound revision.
   Conclusion: Our study demonstrates that a dermal template combined with NPWT can safely and effectively be used to treat complicated wounds in children. Closure was obtained without flaps, the majority of the treatment time was spent in the outpatient setting, and the complication rate was low.
C1 [Hutchison, R. L.] Childrens Mercy Hosp & Clin, Div Orthopaed Surg, Kansas City, MO USA.
   [Hutchison, R. L.; Craw, J. R.] Univ Missouri, Kansas City Sch Med, Dept Orthopaed Surg, Kansas City, MO 64110 USA.
C3 Children's Mercy Hospital; University of Missouri System; University of
   Missouri Kansas City
RP Hutchison, RL (通讯作者)，Childrens Mercy Hosp & Clin, Div Orthopaed Surg, Kansas City, MO USA.
EM rlhutchison@cmh.edu
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NR 32
TC 18
Z9 23
U1 0
U2 13
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2013
VL 22
IS 12
BP 708
EP 712
DI 10.12968/jowc.2013.22.12.708
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 267GQ
UT WOS:000328085200006
PM 24335895
DA 2026-07-24
ER
PT J
AU Seo, SG
   Yeo, JH
   Kim, JIH
   Kim, JB
   Cho, TJ
   Lee, DY
AF Seo, Sang Gyo
   Yeo, Ji Hyun
   Kim, J. I. Hye
   Kim, Ji-Beom
   Cho, Tae-Joon
   Lee, Dong Yeon
TI Negative-pressure wound therapy induces endothelial progenitor cell
   mobilization in diabetic patients with foot infection or skin defects
SO EXPERIMENTAL AND MOLECULAR MEDICINE
LA English
DT Article
DE diabetic foot; endothelial progenitor cell; negative-pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; VASCULOGENESIS; NUMBER
AB Non healing chronic wounds are difficult to treat in patients with diabetes and can result in severe medical problems for these patients and for society. Negative-pressure wound therapy (NPWT) has been adopted to treat intractable chronic wounds and has been reported to be effective. However, the mechanisms underlying the effects of this treatment have not been elucidated. To assess the vasculogenic effect of NPWT, we evaluated the systemic mobilization of endothelial progenitor cells (EPCs) during NPWT. Twenty-two of 29 consecutive patients who presented at the clinic of Seoul National Universty Hospital between December 2009 and November 2010 who underwent NPWT for diabetic foot infections or skin ulcers were included in this study. Peripheral blood samples were taken before NPWT (pre-NPWT) and 7-14 days after the initiation of NPWT (during-NPWT). Fluorescence-activated cell sorting (FACS) analysis showed that the number of cells in EPC-enriched fractions increased after NPWT, and the numbers of EPC colony forming units (CFUs) significantly increased during NPWT. We believe that NPWT is useful for treating patients with diabetic foot infections and skin ulcers, especially when these conditions are accompanied by peripheral arterial insufficiency. The systemic mobilization of EPCs during NPWT may be a mechanism for healing intractable wounds in diabetic patients with foot infections or skin defects via the formation of increased granulation tissue with numerous small blood vessels.
C1 [Seo, Sang Gyo; Yeo, Ji Hyun; Kim, J. I. Hye; Kim, Ji-Beom; Cho, Tae-Joon; Lee, Dong Yeon] Seoul Natl Univ, Coll Med, Dept Orthoped Surg, Seoul, South Korea.
C3 Seoul National University (SNU)
RP Lee, DY (通讯作者)，Seoul Natl Univ Hosp, Dept Orthoped Surg, 101 Daehak Ro, Seoul 110744, South Korea.
EM leedy@snu.ac.kr
RI ; Cho, Tae-Joon/I-9355-2012
OI Seo, Sang Gyo/0000-0003-0145-4066; Cho, Tae-Joon/0000-0001-8514-377X
FU Seoul National University Hospital Research Fund [SNUH-03-2012-0430];
   National Research Foundation of Korea (NRF); Ministry of Education,
   Science and Technology [2010-0021475]
FX This work was supported by the Seoul National University Hospital
   Research Fund (SNUH-03-2012-0430) and by the Basic Science Research
   Program through the National Research Foundation of Korea (NRF), which
   was funded by the Ministry of Education, Science and Technology
   (2010-0021475).
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NR 27
TC 35
Z9 49
U1 0
U2 18
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1226-3613
EI 2092-6413
J9 EXP MOL MED
JI Exp. Mol. Med.
PD NOV
PY 2013
VL 45
AR e62
DI 10.1038/emm.2013.129
PG 5
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA 267UO
UT WOS:000328123900012
PM 24232261
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Joethy, J
   Sebastin, SJ
   Chong, AKS
   Peng, YP
   Puhaindran, ME
AF Joethy, Janna
   Sebastin, Sandeep J.
   Chong, Alphonsus Khin Sze
   Peng, Yeong Pin
   Puhaindran, Mark E.
TI Effect of negative-pressure wound therapy on open fractures of the lower
   limb
SO SINGAPORE MEDICAL JOURNAL
LA English
DT Article
DE free flap; negative-pressure wound therapy; occlusive dressing; open
   tibial fractures; vacuum-aided closure
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY; DEEP INFECTION; TIME-DELAY;
   FREE FLAPS; MANAGEMENT; RECONSTRUCTION; TRAUMA
AB INTRODUCTION Early debridement and coverage has long been regarded as the standard of care for open fractures of the lower limb, as infection is a serious complication. However, the best time for wound closure remains controversial. Negative-pressure wound therapy (NPWT) is thought to result in reduced flap infection and failure. To determine the effect of NPWT, we reviewed patients with open fractures of the lower limb and compared the rates of infection and flap failure in two time-based cohorts.
   METHODS Two cohorts of patients (periods 2003-2004 and 2008-2009) with Gustilo type IIIB open tibial fractures were recruited and their outcomes were compared. In the 2003-2004 cohort, wounds were dressed with occlusive dressing. In the 2008-2009 cohort, all patients underwent NPWT. Data was retrospectively analysed with regard to infection, failure, age, type of flap, comorbidities and defect size. The incidences of infection and flap failure were further analysed for any statistical difference between the different treatment protocols.
   RESULTS In the 2003-2004 cohort, 33% of patients developed infection and 11% had flap failure. However, in the 2008-2009 cohort, 10% of patients developed infection and 6% had flap failure. The difference in the incidence of infection was statistically significant between the two cohorts (p = 0.029).
   CONCLUSION Patients in the 2008-2009 cohort had better outcomes, and we are of the opinion that performing NPWT may have contributed to this result.
C1 [Joethy, Janna] Natl Univ Hlth Syst, Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 119228, Singapore.
   [Sebastin, Sandeep J.; Chong, Alphonsus Khin Sze; Peng, Yeong Pin; Puhaindran, Mark E.] Natl Univ Hlth Syst, Dept Hand & Reconstruct Microsurg, Singapore 119228, Singapore.
C3 National University of Singapore; Singapore General Hospital; National
   University of Singapore
RP Puhaindran, ME (通讯作者)，Natl Univ Hlth Syst, Dept Hand & Reconstruct Microsurg, 1E Kent Ridge Rd,NUHS Tower Block,Level 11, Singapore 119228, Singapore.
EM Mark_E_Puhaindran@nuhs.edu.sg
RI ; /E-7820-2010; Chong, Alphonsus/AGT-2992-2022
OI Chong, Alphonsus/0000-0001-6224-5482; 
CR Ashford RU, 2004, INJURY, V35, P411, DOI 10.1016/S0020-1383(03)00236-5
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NR 19
TC 16
Z9 20
U1 0
U2 5
PU SINGAPORE MEDICAL ASSOC
PI SINGAPORE
PA 2985 JALAN BUKIT MERAH, #02-2C, SMF BUILDING, SINGAPORE, SINGAPORE
SN 0037-5675
J9 SINGAP MED J
JI Singap. Med. J.
PD NOV
PY 2013
VL 54
IS 11
BP 620
EP 623
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 270LY
UT WOS:000328321100012
PM 24276097
DA 2026-07-24
ER
PT J
AU Philouze, G
   Scotté, M
AF Philouze, G.
   Scotte, M.
TI Negative-pressure wound therapy using vacuum assisted closure:
   Principles, techniques and indications
SO PROGRES EN UROLOGIE
LA French
DT Article
DE VAC therapy; Wound healing; Wound defect
AB The Vacuum Assisted Closure therapy (VAC) is an efficient treatment in case of large wound defects with extensive loss of muscular and cutaneous tissues. The success of this therapy is based on strict rules of procedure and regular clinicobiological evaluation before and during treatment. The negative-pressure therapy can lead to a total healing of the defect but a secondary surgical closure or a skin graft can be necessary in some cases. (C) 2013 Elsevier Masson SAS. All rights reserved.
C1 [Philouze, G.; Scotte, M.] CHU Charles Nicolle, Serv Chirurg Gen & Digest, F-76031 Rouen, France.
C3 Universite de Rouen Normandie; CHU de Rouen
RP Scotté, M (通讯作者)，CHU Charles Nicolle, Serv Chirurg Gen & Digest, 1 Rue Germont, F-76031 Rouen, France.
EM michel.scotte@chu-rouen.fr
OI scotté, michel/0000-0001-9519-7632
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Carlson G, 2013, ANN SURG, DOI DOI 10.1097/SLA.0B013E3.8BC8.1828
   Czymek R, 2009, AM J SURG, V197, P168, DOI 10.1016/j.amjsurg.2008.07.053
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   Haute Autorite de sante, 2011, TRAIT PLAIES PRESS N
   Ozturk E, 2009, AM J SURG, V197, P660, DOI 10.1016/j.amjsurg.2008.04.018
   Rao M, 2007, COLORECTAL DIS, V9, P266, DOI 10.1111/j.1463-1318.2006.01154.x
NR 7
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER MASSON, CORP OFF
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1166-7087
EI 2405-5131
J9 PROG UROL
JI Prog. Urol.
PD DEC
PY 2013
VL 23
IS 4
SI SI
BP F106
EP F110
DI 10.1016/j.fpurol.2013.05.006
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 274DW
UT WOS:000328587100002
DA 2026-07-24
ER
PT J
AU Seidel, D
   Lefering, R
   Neugebauer, EAM
AF Seidel, Doerthe
   Lefering, Rolf
   Neugebauer, Edmund A. M.
TI Treatment of subcutaneous abdominal wound healing impairment after
   surgery without fascial dehiscence by vacuum assisted closure™
   (SAWHI-V.A.C®-study) versus standard conventional wound therapy: study
   protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Surgical wound; Wound healing; Wound healing disorder; Wound healing
   impairment; Post-surgical wound healing disorder; Surgical wound
   infection; Abdominal wound healing impairment; Vacuum assisted closure;
   Negative pressure wound therapy; Abdominal wall
ID GENERAL-SURGERY; RISK-FACTORS; PRESSURE; MANAGEMENT; PATIENT; OPTION
AB Background: A decision of the Federal Joint Committee Germany in 2008 stated that negative pressure wound therapy is not accepted as a standard therapy for full reimbursement by the health insurance companies in Germany. This decision is based on the final report of the Institute for Quality and Efficiency in Health Care in 2006, which demonstrated through systematic reviews and meta-analysis of previous study projects, that an insufficient state of evidence regarding the use of negative pressure wound therapy for the treatment of acute and chronic wounds exists. Further studies were therefore indicated.
   Methods/design: The study is designed as a multinational, multicenter, prospective randomized controlled, adaptive design, clinical superiority trial, with blinded photographic analysis of the primary endpoint. Efficacy and effectiveness of negative pressure wound therapy for wounds in both medical sectors (in-and outpatient care) will be evaluated. The trial compares the treatment outcome of the application of a technical medical device which is based on the principle of negative pressure wound therapy (intervention group) and standard conventional wound therapy (control group) in the treatment of subcutaneous abdominal wounds after surgery. The aim of the SAWHI-VAC (R) study is to compare the clinical, safety and economic results of both treatment arms.
   Discussion: The study project is designed and conducted with the aim of providing solid evidence regarding the efficacy of negative pressure wound therapy. Study results will be provided until the end of 2014 to contribute to the final decision of the Federal Joint Committee Germany regarding the general admission of negative pressure wound therapy as a standard of performance within both medical sectors.
C1 [Seidel, Doerthe; Lefering, Rolf; Neugebauer, Edmund A. M.] Univ Witten Herdecke, Fac Hlth, Sch Med, IFOM Inst Res Operat Med, D-51109 Cologne, Germany.
C3 Witten Herdecke University
RP Seidel, D (通讯作者)，Univ Witten Herdecke, Fac Hlth, Sch Med, IFOM Inst Res Operat Med, Ostmerheimer Str 200,Bldg 38, D-51109 Cologne, Germany.
EM Doerthe.Seidel@uni-wh.de
FU Kinetic Concepts Incorporated (KCI)
FX The manufacturer Kinetic Concepts Incorporated (KCI) is funding the
   SAWHI-study. Kelly Simpson, Stacey Pugh, Kathy Sherwood and Alex
   Hartnagel contributed to the first version of the study protocol in
   their role as representatives of the funding company. KCI provided all
   necessary information about the used medical devices and associated
   consumable supplies. Dr. Stefanie de Lange is the deputy leader of the
   Center for Clinical Trials and Innovation of the Institute for Research
   in Operative Medicine. She is the project manager of the study.
   Furthermore she is responsible for all ethical, legal and safety aspects
   of the trial. Steffi de Lange supervises the CRAs working in the
   SAWHI-study and acts as the organizational leader of the trial. Dr.
   Peter Kruger and Dr. Franziska Schwarzkopff are working as data managers
   in the IFOM. They are responsible for the data management of the
   SAWHI-study. Tim Mathes works in the evidence based medicine department
   of the IFOM. He designed and drafted the statistical analysis plan
   supervised by Rolf Lefering. Dr. Melanie Affupper-Fink was the leader of
   the Center for Clinical Trials and Innovation of the Institute for
   Research in Operative Medicine until August 2012 and provided general
   support to the development and conduct of the SAWHI-study. Her successor
   is Dr. Wolfgang Eglmeier.
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NR 32
TC 10
Z9 16
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD NOV 20
PY 2013
VL 14
AR 394
DI 10.1186/1745-6215-14-394
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 276ME
UT WOS:000328753600001
PM 24252551
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Angarita, FA
   Acuna, SA
   Torregrosa, L
   Tawil, M
   Sánchez, EF
   Heilbron, O
   Domínguez, LC
AF Angarita, Fernando A.
   Acuna, Sergio A.
   Torregrosa, Lilian
   Tawil, Mauricio
   Sanchez, Elio F.
   Heilbron, Oscar
   Carlos Dominguez, Luis
TI Bilateral necrotizing fasciitis of the breast following quadrantectomy
SO BREAST CANCER
LA English
DT Article
DE Necrotizing fasciitis; Breast; Soft-tissue infections; Negative-pressure
   wound therapy; Breast cancer
ID SOFT-TISSUE INFECTIONS; VACUUM-ASSISTED CLOSURE; STERNAL WOUND
   INFECTIONS; STREPTOCOCCUS-MILLERI; MORTALITY; MANAGEMENT; THERAPY;
   COMPLEX; SKIN; DETERMINANTS
AB Necrotizing fasciitis (NF) is a rare and highly lethal soft-tissue infection that involves the skin, subcutaneous tissue, and fascia. Although it can affect any part of the body, the breast is seldom involved. We describe a case of bilateral NF of the breast following elective quadrantectomy, successfully treated with antibiotics, bilateral mastectomy, and a vacuum-assisted wound closure system.
C1 [Angarita, Fernando A.] Toronto Gen Res Inst, Div Expt Therapeut, Toronto, ON M5G 2M1, Canada.
   [Acuna, Sergio A.] Mt Sinai Hosp, Peter A Silverman Ctr Int Hlth, Toronto, ON M5G 1X5, Canada.
   [Torregrosa, Lilian; Tawil, Mauricio; Sanchez, Elio F.; Heilbron, Oscar; Carlos Dominguez, Luis] Pontificia Univ Javeriana, Hosp Univ San Ignacio, Dept Surg, Bogota, Colombia.
   [Torregrosa, Lilian; Tawil, Mauricio] Ctr Javeriano Oncol, Breast & Soft Tissue Clin, Bogota, Colombia.
C3 University of Toronto; University Health Network Toronto; Toronto
   General Hospital; University of Toronto; Sinai Health System Toronto;
   Hospital Universitario San Ignacio; Pontificia Universidad Javeriana
RP Angarita, FA (通讯作者)，Toronto Gen Res Inst, Div Expt Therapeut, Room 4-425,67 Coll St, Toronto, ON M5G 2M1, Canada.
EM fernando.angarita@uhnres.utoronto.ca
RI Angarita, Fernando A/AAI-9245-2020; Acuna, Sergio/H-7783-2013
OI Angarita, Fernando A/0000-0002-8546-7309; Acuna,
   Sergio/0000-0002-6266-2136; DOMINGUEZ, LUIS/0000-0002-1595-8364;
   Torregrosa Almonacid, Lilian/0000-0002-5392-7083
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NR 50
TC 14
Z9 17
U1 0
U2 7
PU SPRINGER JAPAN KK
PI TOKYO
PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065,
   JAPAN
SN 1340-6868
EI 1880-4233
J9 BREAST CANCER-TOKYO
JI Breast Cancer
PD JAN
PY 2014
VL 21
IS 1
BP 108
EP 114
DI 10.1007/s12282-010-0219-4
PG 7
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA 277VV
UT WOS:000328848300015
PM 20814771
DA 2026-07-24
ER
PT J
AU Siegel, HJ
AF Siegel, Herrick J.
TI Management of Open Wounds Lessons from Orthopedic Oncology
SO ORTHOPEDIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Sarcoma; Wound complications; Hyperbaric oxygen treatment; Silver
   dressings
ID HYPERBARIC-OXYGEN; SILVER-NITRATE; NANOCRYSTALLINE SILVER; RESISTANCE;
   TISSUE; ANTIBACTERIAL; DRESSINGS; COMPLICATIONS; THERAPY; CLOSURE
AB The management of complex wounds remains a challenge, and although there have been many promising advances, patients often undergo a morbid and lengthy process to obtain sufficient, satisfactory healing. Sarcoma patients are especially vulnerable to soft tissue wound-healing complications. These patients are often treated with neoadjuvant radiation and/or chemotherapy and have compromised local vascularity to healing tissue. The advent and refinement of wound vacuum-assisted closure technology have been shown to have a tremendous impact. This article reviews the benefits of some novel technologies currently undergoing investigation in orthopedic oncology that will likely have applications in wound management from other causes.
C1 Univ Alabama Birmingham, Med Ctr, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Siegel, HJ (通讯作者)，Univ Alabama Birmingham, Med Ctr, Birmingham, AL 35294 USA.
EM hsiegel@uabmc.edu
FU Stryker; Corin
FX Paid consultant for Stryker and Corin.
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NR 40
TC 9
Z9 11
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0030-5898
EI 1558-1373
J9 ORTHOP CLIN N AM
JI Orthop. Clin. North Am.
PD JAN
PY 2014
VL 45
IS 1
BP 99
EP +
DI 10.1016/j.ocl.2013.08.006
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 278VH
UT WOS:000328917500014
PM 24267211
DA 2026-07-24
ER
PT J
AU Sahin, I
   Ozturk, S
   Deveci, M
   Ural, AU
   Onguru, O
   Isik, S
AF Sahin, Ismail
   Ozturk, Sinan
   Deveci, Mustafa
   Ural, Ali Ugur
   Onguru, Onder
   Isik, Selcuk
TI Experimental assessment of the neo-vascularisation of acellular dermal
   matrix in the wound bed pretreated with mesenchymal stem cell under
   subatmospheric pressure
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article; Proceedings Paper
CT 80th Annual Meeting of the American-Society-of-Plastic-Surgeons (ASPS)
CY SEP 23-27, 2011
CL Denver, CO
SP Amer Soc Plast Surg
DE Acellular dermal matrix; Mesenchymal stem cells; Negative pressure wound
   therapy; Neo-vascularisation
ID ENDOTHELIAL GROWTH-FACTOR; IMPROVING GRAFT-SURVIVAL; ASSISTED CLOSURE
   DEVICE; SECURING SKIN-GRAFTS; RECONSTRUCTION; ANGIOGENESIS; REPLACEMENT;
   DRESSINGS; BOLSTER; MODEL
AB Neo-vascularisation of the acellular dermal matrix (ADM) is an essential procedure if a full-thickness wound is closed with ADM and skin is grafted over the ADM.
   In this study, we aimed to improve the neo-vascularisation of ADM by combining the effects of negative pressure wound therapy (NPWT) and mesenchymal stem cells (MSCs) on angiogenesis. In this study, 28 female Sprague-Dawley rats were used and divided into four groups. Full-thickness dorsal skin defects were created in 2 x 2 cm dimensions. The wounds were treated with only the ADM in group 1, the ADM and NPWT in group 2, the ADM and MSCs in group 3 and the ADM, NPWT and MSCs in group 4. By the ninth day of surgery, the excisional biopsy samples were histologically examined to identify the rates of ADM adherence to the recipient bed; the newly formed blood vessels which penetrate the ADM vertically and vascularisation were evaluated by immunohistochemical staining.
   The graft adherence rates were higher in group 4 than in the other groups statistically, p = 0.003. The numbers of cluster of differentiation 31 (CD31)-stained newly formed microvessels were higher in group 4 than in the other groups statistically, p < 0.05. All subjects in group 4 had the vertical vessels in normal calibration with open lumen vessels which penetrate the ADM.
   These findings suggest that MSC transplantation induces angiogenesis more efficiently than NPWT. The combination of the NPWT with MSC in this study has shown a synergistic effect on angiogenesis and has affected the neo-vascularisation of the ADM significantly. (C) 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Sahin, Ismail; Ozturk, Sinan; Isik, Selcuk] Gulhane Mil Med Acad, Dept Plast & Reconstruct Surg, TR-06010 Ankara, Turkey.
   [Deveci, Mustafa] Numune Egitim & Arastirma Hastanesi, Dept Plast & Reconstruct Surg, Ankara, Turkey.
   [Ural, Ali Ugur] Bayindir Hosp, Dept Haematol, Ankara, Turkey.
   [Onguru, Onder] Gulhane Mil Med Acad, Dept Pathol, TR-06010 Ankara, Turkey.
C3 Gulhane Training & Research Hospital; Ankara Numune Training & Research
   Hospital; Bayindir Hastanesi; Bayindir Health Group; Gulhane Training &
   Research Hospital
RP Sahin, I (通讯作者)，Gulhane Mil Med Acad, Dept Plast & Reconstruct Surg, TR-06010 Ankara, Turkey.
EM drismailsahin@yahoo.com
RI /AAJ-4406-2021
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   Wong AK, 2008, PLAST RECONSTR SURG, V121, P1144, DOI 10.1097/01.prs.0000302505.43942.07
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NR 25
TC 14
Z9 16
U1 0
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JAN
PY 2014
VL 67
IS 1
BP 107
EP 114
DI 10.1016/j.bjps.2013.08.001
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 282XU
UT WOS:000329208900025
PM 24055332
DA 2026-07-24
ER
PT J
AU Mangukia, CV
   Agarwal, S
   Satyarthy, S
   Datt, V
   Satsangi, D
AF Mangukia, Chirantan V.
   Agarwal, Saket
   Satyarthy, Subodh
   Datt, Vishnu
   Satsangi, Deepak
TI Mediastinitis Following Pediatric Cardiac Surgery
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Review
ID DELAYED STERNAL CLOSURE; VACUUM-ASSISTED CLOSURE; SURGICAL-SITE
   INFECTIONS; OPEN-HEART-SURGERY; MEDIAN STERNOTOMY INFECTION;
   RISK-FACTORS; POSTOPERATIVE MEDIASTINITIS; MUSCLE FLAPS;
   WOUND-INFECTION; CARDIOVASCULAR-SURGERY
AB BackgroundMediastinitis following pediatric cardiac surgery is associated with significantly high morbidity and mortality.
   MethodIn our review, 21 studies from 1986 to 2011 (12 retrospective studies, eight prospective studies, and a multi-institutional study) including 44,693 pediatric cardiac patients were analyzed.
   Results and ConclusionYounger age, malnutrition, preoperative respiratory tract infection, high American anesthesiology score, longer duration of surgery, prolonged ventilation, and ICU stay were definite risk factors for mediastinitis. Early primary closure over drains, vacuum-assisted closure, muscle flap, and omental flap remain the most frequently performed treatments for post-sternotomy mediastinitis. Vacuum-assisted closure has emerged as the technique of choice in recent years. doi: 10.1111/jocs.12243 (J Card Surg 2014;29:74-82)
C1 [Mangukia, Chirantan V.; Agarwal, Saket; Satyarthy, Subodh; Satsangi, Deepak] GB Pant Hosp, Dept Cardiothorac & Vasc Surg, New Delhi, India.
   [Datt, Vishnu] GB Pant Hosp, Dept Anesthesiol, New Delhi, India.
C3 Govind Ballabh Pant Institute of Postgraduate Medical Education &
   Research; Govind Ballabh Pant Institute of Postgraduate Medical
   Education & Research
RP Mangukia, CV (通讯作者)，GB Pant Hosp, Dept CTVS, New Delhi, India.
EM cvm2585@gmail.com
RI Mangukia, Chirantan/M-9486-2018
OI Mangukia, Chirantan/0000-0001-7950-2238
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NR 80
TC 12
Z9 16
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD JAN
PY 2014
VL 29
IS 1
BP 74
EP 82
DI 10.1111/jocs.12243
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 284HO
UT WOS:000329307000013
PM 24267786
DA 2026-07-24
ER
PT J
AU Costello, JP
   Amling, JK
   Emerson, DA
   Peer, SM
   Afflu, DK
   Zurakowski, D
   Jonas, RA
   Nath, DS
AF Costello, J. P.
   Amling, J. K.
   Emerson, D. A.
   Peer, S. M.
   Afflu, D. K.
   Zurakowski, D.
   Jonas, R. A.
   Nath, D. S.
TI Negative pressure wound therapy for sternal wound infections following
   congenital heart surgery
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; sternal wound infection; congenital
   heart surgery; mediastinitis
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE MEDIASTINITIS; CARDIAC-SURGERY;
   MANAGEMENT
AB Objective: This study examines the efficacy of a comprehensive, multidisciplinary wound management team and negative pressure wound therapy (NPWT) for the treatment of sternal wound infections in congenital heart surgery patients.
   Method: A single-institution retrospective review of all congenital heart surgery patients with postoperative sternal wound infections who were treated with NPWT was performed. Patients were evaluated based on (a) whether NPWT occurred before or after the establishment of a multidisciplinary wound management team, and (b) whether NPWT was initiated early (within 2 days) or late (greater than 2 days) after diagnosis of a sternal wound infection.
   Results: The median duration of NPWT was 12 days (range 2-50 days). NPWT was successfully initiated in patients as young as 15 days of age. There was a trend toward shorter duration of both NPWT and antibiotic use following (a) the implementation of the multidisciplinary wound management team, and (b) in patients with early use of NPWT; however, these results did not achieve statistical significance.
   Conclusion: NPWT can be successfully utilised in congenital heart surgery patients, including young neonates, for the treatment of sternal wound infections. The trends observed in the reduction of wound therapy duration and antibiotic duration with early implementation of negative pressure therapy and multidisciplinary wound management require further investigation to verify their clinical efficacy in patient care.
C1 [Costello, J. P.; Emerson, D. A.; Peer, S. M.; Afflu, D. K.; Jonas, R. A.; Nath, D. S.] Childrens Natl Hlth Syst, Div Cardiovasc Surg, Washington, DC USA.
   [Costello, J. P.] Childrens Natl Hlth Syst, Sheikh Zayed Inst Pediat Surg Innovat, Washington, DC USA.
   [Amling, J. K.] Childrens Natl Hlth Syst, Wound & Surg Airway Program, Washington, DC USA.
   [Zurakowski, D.] Harvard Univ, Sch Med, Dept Anaesthesia, Boston Childrens Hosp, Boston, MA 02115 USA.
   [Zurakowski, D.] Harvard Univ, Sch Med, Dept Surg, Boston Childrens Hosp, Boston, MA 02115 USA.
C3 Children's National Health System; Children's National Health System;
   Children's National Health System; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital; Harvard
   Medical School; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Boston Children's Hospital
RP Costello, JP (通讯作者)，Childrens Natl Hlth Syst, Div Cardiovasc Surg, Washington, DC USA.
EM dnath@childrensnational.org
RI ; Peer, Syed/ABD-8308-2020
OI Emerson, Dominic/0000-0001-5728-0152; Afflu, Derek/0000-0002-8146-029X;
   Peer, Syed/0000-0003-0859-2496
CR Al-Sehly AA, 2005, ANN THORAC SURG, V80, P2314, DOI 10.1016/j.athoracsur.2005.05.035
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NR 15
TC 14
Z9 17
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2014
VL 23
IS 1
BP 31
EP 36
DI 10.12968/jowc.2014.23.1.31
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 286GX
UT WOS:000329456100005
PM 24406541
DA 2026-07-24
ER
PT J
AU Tan, A
   Gollop, ND
   Klimach, G
   Maruthappu, M
   Smith, SF
AF Tan, A.
   Gollop, N. D.
   Klimach, G.
   Maruthappu, M.
   Smith, S. F.
TI Should infected laparotomy wounds be treated with negative pressure
   wound therapy?
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Infected laparotomy; Negative pressure wound therapy; Vacuum associated
   closure therapy
ID POLYURETHANE-FOAM; GAUZE
AB A best evidence topic in surgery was written according to a structured protocol. The question addressed whether there is any benefit in treating infected laparotomy wounds with negative pressure wound therapy (NPWT). Forty-five papers were found using the reported search; of which 4 represented the best evidence to answer the question. The evidence on this subject is limited; there is a single non-randomised controlled trial, 2 prospective cohort studies, and 1 retrospective cohort study discussed in this paper. From the available literature, the use of NPWT in infected laparotomy wounds does reduce the length of hospital stay, the number of dressing changes required and promote faster wound healing. (C) 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [Tan, A.] Univ Edinburgh, Sch Med, Edinburgh EH8 9YL, Midlothian, Scotland.
   [Gollop, N. D.] Norfolk & Norwich Univ Hosp, Norwich NR4 7UY, Norfolk, England.
   [Klimach, G.] Univ Sussex, Sch Med, Brighton, E Sussex, England.
   [Maruthappu, M.] Univ Oxford, Sch Med, Oxford OX1 2JD, England.
   [Smith, S. F.] Univ Cambridge, Sch Med, Cambridge CB2 1TN, England.
C3 University of Edinburgh; Norfolk & Norwich University Hospitals NHS
   Foundation Trust; Norfolk & Norwich University Hospital; University of
   Sussex; University of Oxford; University of Cambridge
RP Gollop, ND (通讯作者)，Norfolk & Norwich Univ Hosp, Norwich NR4 7UY, Norfolk, England.
EM n.gollop@doctors.org.uk
RI Smith, Stephanie/AAK-3690-2020
OI Smith, Stephanie/0000-0001-9290-3773
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   Dorafshar AH, 2012, ANN PLAS SURG, V69, P79, DOI 10.1097/SAP.0b013e318221286c
   Khan OA, 2011, INT J SURG, V9, P585, DOI 10.1016/j.ijsu.2011.08.001
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   Malmsjö M, 2009, WOUND REPAIR REGEN, V17, P200, DOI 10.1111/j.1524-475X.2009.00461.x
   Marquardt C, 2008, GAUZE VERSUS FOAM TO
   Marquardt C, 2011, SURG SITE INFECT MED
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   Zhen ZJ, 2011, INT J SURG, V9, P378, DOI 10.1016/j.ijsu.2011.02.012
NR 10
TC 12
Z9 12
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PY 2014
VL 12
IS 1
BP 26
EP 29
DI 10.1016/j.ijsu.2013.11.002
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 288KX
UT WOS:000329612000006
PM 24246173
DA 2026-07-24
ER
PT J
AU Kairinos, N
   Holmes, WJM
   Solomons, M
   Hudson, DA
   Kahn, D
AF Kairinos, Nicolas
   Holmes, William J. M.
   Solomons, Michael
   Hudson, Donald A.
   Kahn, Delawir
TI Does a Zone of Increased Perfusion Exist around Negative-Pressure
   Dressings?
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; MICROVASCULAR
   BLOOD-FLOW; LASER-DOPPLER FLOWMETRY; WOUND-THERAPY; INTERMITTENT;
   RESPONSES
AB Background: Although recent work has demonstrated that perfusion adjacent to a negative-pressure wound therapy dressing is decreased, laser Doppler studies have indicated that there is a zone of increased perfusion a couple of centimeters away. The existence of such a zone of increased perfusion is counterintuitive to the fact that negative-pressure wound therapy has been shown to increase tissue pressure. This study, using an alternative to laser Doppler, evaluated whether such a zone exists.
   Methods: Six volunteers were randomized into three groups to test different suction pressures (-75, -125, and -400 mmHg). Each volunteer would have two dressings applied on either side of the lower back. A thermal imaging camera was used to assess perfusion around the dressing during different phases (e.g., Suction on and Suction off). The mean area under the curve for each phase was compared with those of other phases by means of one-way analysis of variance. Each condition (phase) was compared in a systematic manner with every other by means of Fisher's least significant difference for post hoc comparisons. A Pearson's correlation was determined to test the effects of the different suction pressure groups.
   Results: No significant difference could be demonstrated for the area under the curve for the different phases. There was no significant correlation between the three suction pressures tested and the difference between the mean area under the curve for Dressing on, no suction and the two Suction on periods (Pearson correlation = 0.24; p > 0.4).
   Conclusions: Thermographic evaluation of tissue around a negative-pressure dressing did not demonstrate a zone of increased perfusion, contrary to other studies, which used laser Doppler. This is in keeping with recent work demonstrating that negative-pressure wound therapy increases tissue pressure while the dressing is applying suction.
   CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V.
C1 Univ Cape Town, Dept Plast Surg, ZA-7925 Cape Town, South Africa.
   Univ Cape Town, Dept Orthopaed Surg, Martin Singer Hand Unit, ZA-7925 Cape Town, South Africa.
   Univ Cape Town, Dept Surg, ZA-7925 Cape Town, South Africa.
   Groote Schuur Hosp, ZA-7925 Cape Town, South Africa.
C3 University of Cape Town; University of Cape Town; University of Cape
   Town; University of Cape Town
RP Kairinos, N (通讯作者)，5 Pipit Lane,Century Dr, ZA-7441 Cape Town, South Africa.
EM nickykairinos@gmail.com
FU Department of Surgery, Groote Schuur Hospital, Cape Town; Kinetic
   Concepts Inc., South Africa; Thermal Health Solutions, South Africa
FX The authors have no financial disclosures or conflicts of interest to
   declare. This study was funded by the Department of Surgery, Groote
   Schuur Hospital, Cape Town. The Vacuum-Assisted Closure dressings were
   sponsored by Kinetic Concepts Inc., South Africa. The thermal image
   camera was sponsored by Thermal Health Solutions, South Africa.
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NR 38
TC 23
Z9 26
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2013
VL 132
IS 4
BP 978
EP 987
DI 10.1097/PRS.0b013e31829f4ad9
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 290ZE
UT WOS:000329796500079
PM 23783056
DA 2026-07-24
ER
PT J
AU Wang, XG
   Zhang, YH
   Han, CM
AF Wang, Xingang
   Zhang, Yuanhai
   Han, Chunmao
TI Topical negative pressure improves autograft take by altering nutrient
   diffusion: A hypothesis
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE topical negative pressure; wound healing; autograft
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; CLINICAL
   EFFECTIVENESS; BURNS; SKIN; SURGERY; THERAPY; INTEGRA
AB The one-step surgical procedure for dermal substitutes combined with topical negative pressure (TNP) has proven effective for treating deep skin defects with improved graft take. The primary mechanism by which TNP improves autograft take is unknown. Some studies suggest that TNP promotes the rapid angiogenesis of dermal substitutes, improving graft take. However, at the early stage of one-step transplantation, the vascular system has not formed and imbibition is the main mode of nutrient supply. TNP can shorten the diffusion distance from the wound bed to the graft, leading to the timely renewal of the wound exudate via suction, removing any surplus exudate, and reducing tissue edema. In addition, TNP can regulate the local blood flow and inhibit bacterial colonization. Therefore, we hypothesized that TNP establishes a rapid balance between the nutrient supply to the wound bed and nutritional requirement of the graft via these pathways in the relatively closed, moist environment, improving autograft take. However, this balance could be affected by any negative pressure, intermittent or continuous. It is necessary to test this hypothesis in laboratory and clinical studies of the mode of nutrient supply in the imbibition phase and the change in exudate content.
C1 [Wang, Xingang; Han, Chunmao] Zhejiang Univ, Affiliated Hosp 2, Dept Burns, Hangzhou 310003, Zhejiang, Peoples R China.
   [Wang, Xingang; Han, Chunmao] Zhejiang Univ, Affiliated Hosp 2, Wound Care Ctr, Hangzhou 310003, Zhejiang, Peoples R China.
   [Zhang, Yuanhai] Quhua Hosp, Dept Burns & Plast Surg, Quzhou, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Wang, XG (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Dept Burns, Hangzhou 310003, Zhejiang, Peoples R China.
EM wxg8157@163.com
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NR 18
TC 8
Z9 9
U1 0
U2 7
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JAN 16
PY 2014
VL 20
BP 61
EP 63
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 291XH
UT WOS:000329865400001
PM 24435118
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Bonds, AM
   Novick, TK
   Dietert, JB
   Araghizadeh, FY
   Olson, CH
AF Bonds, Allison M.
   Novick, Tessa K.
   Dietert, Jessica B.
   Araghizadeh, Farshid Y.
   Olson, Craig H.
TI Incisional Negative Pressure Wound Therapy Significantly Reduces
   Surgical Site Infection in Open Colorectal Surgery
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE Wound closure; Wound healing; Outcomes research; Colon and rectal
   surgery
ID PERIOPERATIVE INTRAPERITONEAL CHEMOTHERAPY; SYNCHRONOUS PERITONEAL
   CARCINOMATOSIS; CYTOREDUCTIVE SURGERY; LIVER METASTASES; HYPERTHERMIC
   CHEMOTHERAPY; CANCER PATIENTS; ORIGIN; SURVIVAL; OUTCOMES;
   CHEMOHYPERTHERMIA
AB BACKGROUND: Surgical site infections in colorectal surgery remain a common problem, and are associated with an increase in cost of care and length of stay.
   OBJECTIVE: This study aims to evaluate the effect of known risk factors and the use of incisional negative pressure wound therapy on surgical site infection rates.
   DESIGN: This is a single-center retrospective study with the use of chart review.
   SETTINGS: The study took place at a tertiary academic medical center.
   PATIENTS: All patients undergoing open colectomy at a single institution from 2009 through 2011 were studied.
   MAIN OUTCOME MEASURES: The primary outcome measured was the presence or absence of surgical site infection.
   RESULTS: Overall, 69 of the 254 patients (27.2%) experienced surgical site infection; 4 (12.5%) surgical site infections were seen in patients undergoing incisional negative pressure wound therapy and 65 (29.3%) were seen in patients undergoing standard closure. Multiple logistic regression revealed 2 significant factors: diabetes mellitus increased the chance of surgical site infection (OR, 1.98; p < 0.05), and the use of incisional negative pressure wound therapy decreased the chance of surgical site infection (OR, 0.32; p < 0.05). Obesity was associated with a trend toward increasing surgical site infection (OR, 1.64; p = 0.10).
   LIMITATIONS: This study is limited by its retrospective nature and the high baseline prevalence of surgical site infection.
   CONCLUSIONS: Incisional negative pressure wound therapy appears to reduce surgical site infection in open colorectal surgery. Further study may be helpful to identify patient populations who would have the greatest benefit from this technique (see Video, Supplemental Digital Content 1, http://links.lww.com/DCR/A115).
C1 [Bonds, Allison M.; Novick, Tessa K.; Dietert, Jessica B.; Araghizadeh, Farshid Y.; Olson, Craig H.] Univ Texas Southwestern, Sect Colorectal Surg, Dept Surg, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center
RP Olson, CH (通讯作者)，Univ Texas Southwestern, 1801 Inwood Rd,Ste WA4 416, Dallas, TX 75390 USA.
EM Craig.Olson@utsouthwestern.edu
OI Novick, Tessa/0000-0002-5659-8772
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   Varban O, 2009, CANCER-AM CANCER SOC, V115, P3427, DOI 10.1002/cncr.24385
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   Yan TD, 2006, EJSO-EUR J SURG ONC, V32, P1119, DOI 10.1016/j.ejso.2006.06.007
NR 39
TC 87
Z9 97
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD DEC
PY 2013
VL 56
IS 12
BP 1403
EP 1408
DI 10.1097/DCR.0b013e3182a39959
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 292SR
UT WOS:000329923200013
PM 24201395
DA 2026-07-24
ER
PT J
AU Zhou, M
   Qi, BW
   Yu, AX
   Pan, ZY
   Zhu, SB
   Deng, K
   Tao, SX
AF Zhou, Min
   Qi, Baiwen
   Yu, Aixi
   Pan, Zhenyu
   Zhu, Shaobo
   Deng, Kai
   Tao, Shengxiang
TI VACUUM ASSISTED CLOSURE THERAPY FOR TREATMENT OF COMPLEX WOUNDS IN
   REPLANTED EXTREMITIES
SO MICROSURGERY
LA English
DT Article
ID NEGATIVE-PRESSURE; MANAGEMENT; RECONSTRUCTION; FRACTURES; INFECTION
AB The object of this study was to compare the outcomes of the vacuum assisted closure (VAC) therapy and conventional wound care with dressing change for treatment of complex wounds in patients with replantation of amputated upper and lower extremities. Data of 43 patients with replantation of amputated extremities from May 2004 to December 2011 were reviewed. There were 18 wounds of 18 patients with replantation, which were treated by dressing change and 26 wounds of 25 patients by VAC therapy. The outcomes were evaluated by the survival rate of replanted extremities, growth of granulation tissue, interval between wound treatment and secondary procedure and eventual secondary wound coverage methods. Vascular thromboses were found in 3 patients with wound treatment by dressing change and 5 by VAC. All replants of two groups of patients survived after salvage procedures. The wound score was 3.6 +/- 0.7 in the conventional dressing change group and 5.8 +/- 0.7 in the VAC group at the sixth day after treatment, respectively. The intervals between wound treatment and secondary wound coverage procedure were 12.0 +/- 1.7 days in the dressing change group and 6.1 +/- 0.7 days in the VAC group. Flaps were applied for wound coverage in 9 out of 18 (50.0%) wounds in the dressing change group and 5 out of 26 (19.2%) in the VAC group (P < 0.05), when the wounds of rest of patients were covered by the skin graft. The results showed that VAC could promote the growth of granulation tissue of wound, decrease the need of flap for wound coverage, and did not change the survival of replantation. (C) 2013 Wiley Periodicals, Inc.
C1 [Zhou, Min; Qi, Baiwen; Yu, Aixi; Pan, Zhenyu; Zhu, Shaobo; Deng, Kai; Tao, Shengxiang] Wuhan Univ, Dept Orthoped Microsurg, Zhongnan Hosp, Wuhan 430071, Hubei Province, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Dept Orthoped Microsurg, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei Province, Peoples R China.
EM yuaixi666@163.com
OI Yu, Aixi/0000-0002-3751-0894
FU National Natural Science Funds of China [81171713]
FX Grant sponsor: National Natural Science Funds of China; Grant number:
   81171713.
CR Ahuja NK, 2012, MICROSURG, V32, P196, DOI 10.1002/micr.20966
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   Battiston B, 2002, MICROSURG, V22, P187, DOI 10.1002/micr.22505
   Blume P, 2011, WOUND REPAIR REGEN, V19, P302, DOI 10.1111/j.1524-475X.2011.00669.x
   Bowler PG, 2013, J HOSP INFECT, V83, P232, DOI 10.1016/j.jhin.2012.11.018
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   Murray RC, 2011, MICROSURG, V31, P104, DOI 10.1002/micr.20833
   Niu Z, 2006, ZHONG HUA XIAN WEI W, V29, P462
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   Rozen WM, 2008, J PLAST RECONSTR AES, V61, P334, DOI 10.1016/j.bjps.2007.01.064
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   Yoshida S, 2011, MICROSURG, V31, P655, DOI 10.1002/micr.20932
NR 30
TC 15
Z9 18
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD NOV
PY 2013
VL 33
IS 8
BP 620
EP 624
DI 10.1002/micr.22178
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 296LJ
UT WOS:000330186200007
PM 24307267
DA 2026-07-24
ER
PT J
AU Wen, G
   Wang, CY
   Chai, YM
   Cheng, L
   Chen, M
   Lv, YM
AF Wen, Gen
   Wang, Chun-Yang
   Chai, Yi-Min
   Cheng, Liang
   Chen, Ming
   Lv, Yi-Min
TI DISTALLY BASED SAPHENOUS NEUROCUTANEOUS PERFORATOR FLAP COMBINED WITH
   VAC THERAPY FOR SOFT TISSUE RECONSTRUCTION AND HARDWARE SALVAGE IN THE
   LOWER EXTREMITIES
SO MICROSURGERY
LA English
DT Article
ID PRESSURE WOUND THERAPY; ASSISTED CLOSURE THERAPY; NEGATIVE-PRESSURE;
   MUSCULOCUTANEOUS FLAP; CLINICAL-EXPERIENCE; TIBIAL FRACTURES;
   SPINAL-FUSION; ISLAND FLAP; FREE MUSCLE; COVERAGE
AB The complex wound with the exposed hardware and infection is one of the common complications after the internal fixation of the tibia fracture. The salvage of hardware and reconstruction of soft tissue defect remain challenging. In this report, we presented our experience on the use of the distally based saphenous neurocutaneous perforator flap combined with vacuum-assisted closure ( VAC) therapy for the coverage of the soft tissue defect and the exposed hardware in the lower extremity with fracture. Between January 2008 and July 2010, seven patients underwent the VAC therapy followed by transferring a reversed saphenous neurocutaneous perforator flap for reconstruction of the wound with exposed hardware around the distal tibia. The sizes of the flaps ranged from 6 x 3 cm to 15 x 6 cm. Six flaps survived completely. Partial necrosis occurred in one patient. There were no other complications of repair and donor sites. Bone healing was achieved in all patients. In conclusion, the reversed saphenous neurocutaneous perfortor flaps combined with the VAC therapy might be one of the options to cover the complex wound with exposed hardware in the lower extremities. (C) 2013 Wiley Periodicals, Inc.
C1 [Wen, Gen; Wang, Chun-Yang; Chai, Yi-Min; Cheng, Liang; Chen, Ming; Lv, Yi-Min] Jiao Tong Univ, Dept Orthoped Surg, Shanghai Peoples Hosp 6, Shanghai 200233, Peoples R China.
C3 Shanghai Jiao Tong University
RP Chai, YM (通讯作者)，Jiao Tong Univ, Dept Orthoped Surg, Shanghai Peoples Hosp 6, 600 YiShan Rd, Shanghai 200233, Peoples R China.
EM chaiyimin@gmail.com
RI 文, 根/JWP-9726-2024
FU Science and Technology Commission of Shanghai Municipality Program
   [11JC1409400]
FX Grant sponsor: Science and Technology Commission of Shanghai
   Municipality Program; grant number: 11JC1409400.
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NR 41
TC 16
Z9 22
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD NOV
PY 2013
VL 33
IS 8
BP 625
EP 630
DI 10.1002/micr.22162
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 296LJ
UT WOS:000330186200008
PM 23946231
DA 2026-07-24
ER
PT J
AU Armstrong, DG
   Isaac, AL
   Bevilacqua, NJ
   Wu, SC
AF Armstrong, David G.
   Isaac, Adam L.
   Bevilacqua, Nicholas J.
   Wu, Stephanie C.
TI Offloading Foot Wounds in People with Diabetes
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE diabetic foot ulcer; offloading; total contact casting; review
ID TOTAL CONTACT CASTS; RANDOMIZED CONTROLLED-TRIAL; PLANTAR ULCERATION;
   CLINICAL-TRIAL; HEALING RATES; ULCERS; PRESSURE; MANAGEMENT; WALKERS;
   DEVICES
AB Up to 25% of people with diabetes will develop a foot ulcer at some point during their lifetime, and 1 in 5 will require an amputation. In 2006, more than 65,700 lower-limb amputations were performed in the United States alone in people with diabetes, and the 5-year mortality rate following an amputation is worse than for most malignancies. Along with an interdisciplinary team approach to diabetic limb salvage, "toe and flow," a vertical and horizontal approach to wound healing, is changing the way these patients are cared for. The vertical strategy for wound healing refers to covering important structures and filling defects with negative pressure wound therapy, while the horizontal strategy utilizes skin grafting, bioengineered skin substitutes, and aggressive offloading. The gold standard for offloading foot wounds in people with diabetes is total contact casting, however, recent studies have shown that the modality is seldom used in the current clinical setting. Other offloading devices include removable cast walkers, half shoes, healing sandals, and, more recently, lightweight, rapidly custom-built braces. Offloading of the diabetic foot is often overlooked as a critical part of wound healing, but past experience guides the authors to the conclusion that it is often not what one puts on the wound, but rather what is taken off that primarily affects healing in many of these patients.
C1 [Armstrong, David G.] Univ Arizona, Coll Med, Tucson, AZ 85721 USA.
   [Isaac, Adam L.] Mid Atlantic Permanente Med Grp, Rockville, MD USA.
   [Bevilacqua, Nicholas J.] North Jersey Orthopaed Specialists, Teaneck, NJ USA.
   [Wu, Stephanie C.] Rosalind Franklin Univ Med & Sci, Chicago, IL USA.
C3 University of Arizona; Permanente Medical Groups; Chicago Medical
   School; Rosalind Franklin University of Medicine & Science
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, Tucson, AZ 85721 USA.
EM armstrong@usa.net
RI Isaac, Adam/L-9111-2019
OI Isaac, Adam/0000-0001-5338-3445
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NR 43
TC 14
Z9 22
U1 0
U2 14
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2014
VL 26
IS 1
BP 13
EP 20
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 297PH
UT WOS:000330266900003
DA 2026-07-24
ER
PT J
AU Hutan, M
   Sen, HM
   Skultety, J
   Sekac, J
   Koudelka, P
   Prochotsky, A
   Yaghi, A
   Labas, P
AF Hutan, M., Jr.
   Sen, Hutan M.
   Skultety, J.
   Sekac, J.
   Koudelka, P.
   Prochotsky, A.
   Yaghi, A.
   Labas, P.
TI Use of intraabdominal VAC (Vacuum Assisted Closure) lowers mortality and
   morbidity in patients with open abdomen
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE VAC; open abdomen; Kern laparostomy; SMAC; dynamic compression sutures
AB Objective: Authors compare two groups of patients with open abdomen. The objective is to compare and evaluate two treatment modalities, namely Kern laparostomy and vacuum-assisted closure in terms of mortality, closure of abdominal wound, and fistula management, all these stratified by BMI and CRP.
   Background: Open abdomen can be considered a "patient salvage technique", used in patients with abdominal sepsis, as well as in patients with abdominal compartment syndrome, and in damage control surgery. Various management techniques are known, of which Kern laparostomy is most widely used. Newer techniques using negative pressure have emerged, still waiting for their wider acceptance and use. The authors present their study, in which they compare Kern laparostomy and intraabdominal VAC in patients with open abdomen.
   Material and methods: Study consists of 44 patients treated at the authors clinics, while group KERN consisted of patients managed by Kern laparostomy, and group VAC was managed by intraabdominal VAC. The groups were compared in terms of mortality, abdominal closure, appearance of enteroatmospheric fistulas, primary closure of fistulas, and possibility of diversion of enteral contents. All outputs were stratified by CRP (C-reactive protein) and BMI (Body Mass Index).
   Results: In VAC group, a significant decrease in mortality was seen, as well as significantly higher closure of abdominal wall, and significantly higher possibility of diversion of enteral content from fistulas. No statistically significant findings were observed in stratification with CRP and BMI.
   Conclusion: Intraabdominal VAC offers patients lower morbidity and mortality and should be defined as a treatment of choice in patients with open abdomen (Tab. 4, Fig. 3, Ref. 15). Full Text in PDF www.elis.sk.
C1 [Hutan, M., Jr.; Skultety, J.; Sekac, J.; Koudelka, P.; Prochotsky, A.] Comenius Univ, Univ Hosp Bratislava, Hosp St Cyril & Methodius, Sch Med,Surg Clin 2, SK-85107 Bratislava, Slovakia.
   [Sen, Hutan M.] Comenius Univ, Univ Hosp Bratislava, Hosp Ruzinov, Sch Med,Surg Clin 4, SK-85107 Bratislava, Slovakia.
   [Yaghi, A.] Hosp Ruzinov, Univ Hosp Bratislava, Anaesthesiol & Intens Med Clin, Bratislava, Slovakia.
   [Labas, P.] Comenius Univ, Univ Hosp Bratislava, Hosp Stare Mesto, Sch Med,Surg Clin 1, SK-85107 Bratislava, Slovakia.
C3 Comenius University Bratislava; Slovak Medical University Bratislava;
   Slovak Medical University Bratislava; Comenius University Bratislava;
   Slovak Medical University Bratislava; Comenius University Bratislava;
   Slovak Medical University Bratislava
RP Hutan, M (通讯作者)，Comenius Univ, Univ Hosp Bratislava, Hosp St Cyril & Methodius, Sch Med,Surg Clin 2, Antolska 11, SK-85107 Bratislava, Slovakia.
EM matohuto@yahoo.com
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   Caro A, 2011, INT WOUND J, V211
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   Evenson RA, 2006, CHIRURG, V77, P594, DOI 10.1007/s00104-006-1207-2
   Goverman J, 2006, J TRAUMA, V60, P428, DOI 10.1097/01.ta.0000203588.66012.c4
   Hutan M, 2010, BRATISL MED J, V111, P461
   Joyce MR, 2006, CURR PROB SURG, V46, P384
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   Shaikh IA, 2010, COLORECTAL DIS, V12, P931, DOI 10.1111/j.1463-1318.2009.01929.x
   Stremitzer S, 2011, INT J COLORECT DIS
NR 15
TC 7
Z9 7
U1 0
U2 3
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2013
VL 114
IS 8
BP 451
EP 454
DI 10.4149/BLL_2013_094
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 297QL
UT WOS:000330269900005
PM 23944619
OA Bronze
DA 2026-07-24
ER
PT J
AU Schlüer, AB
   Schols, JMGA
   Halfens, RJG
AF Schlueer, Anna-Barbara
   Schols, Jos M. G. A.
   Halfens, Ruud J. G.
TI Pressure Ulcer Treatment in Pediatric Patients
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE pressure ulcer; pediatric nursing; wound care in pediatrics;
   negative-pressure wound therapy
ID SKIN; WOUNDS; PREVALENCE; MANAGEMENT; THERAPY; ADULT; FLAP
AB OBJECTIVE: To assess pressure ulcer (PrU) treatment in Swiss hospitalized pediatric patients and to determine whether there are differences in PrU treatment, according to demographic characteristics of the patients.
   DESIGN: A descriptive multicenter point prevalence study was conducted in June 2009 in all German-speaking pediatric hospitals in Switzerland.
   SETTING: All hospitalized patients from birth up to 17 years or younger in 14 Swiss pediatric hospitals, including all pediatric departments, were assessed.
   PATIENTS: A total of 412 patients participated in this study.
   MAIN OUTCOME MEASURES: The instrument and method of the Dutch National Prevalence Measurement of Care Problems were used.
   MAIN RESULTS: Thirty-five percent of the patients had a PrU. Almost all of these PrUs (94.1%) were of category 1. The most severe PrUs occurred in patients older than 8 years. Age of the patient and department were the only characteristics that significantly influenced the occurrence of PrU categories 2 to 4. Pressure ulcer categories 2 to 4 were mostly covered with hydrocolloid or polyurethane foam dressings. No pediatric-specific guideline regarding PrU treatment is used in the involved hospitals.
   CONCLUSION: Most patients had category 1 PrUs, so appropriate prevention to decrease any further trauma in these patients was necessary. Severe PrUs (categories 2-4) are mostly limited to older pediatric (aged 98 years) patients with chronic conditions or after surgery intervention. A PrU treatment guideline adapted for pediatric needs is recommended.
C1 [Schlueer, Anna-Barbara] Univ Childrens Hosp Zurich, Dept Nursing Dev & Sci, Zurich, Switzerland.
   [Schlueer, Anna-Barbara] Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland.
   [Schols, Jos M. G. A.] CAPHRI Maastricht Univ, Dept Family Med, Maastricht, Netherlands.
   [Schols, Jos M. G. A.] CAPHRI Maastricht Univ, Dept Hlth Serv Res, Maastricht, Netherlands.
   [Halfens, Ruud J. G.] CAPHRI Maastricht Univ, Dept Hlth Serv Res, Maastricht, Netherlands.
C3 University Children's Hospital Zurich; University Children's Hospital
   Zurich; Maastricht University; Maastricht University; Maastricht
   University
RP Schlüer, AB (通讯作者)，Univ Childrens Hosp Zurich, Dept Nursing Dev & Sci, Zurich, Switzerland.
OI Schlüer, Anna-Barbara/0000-0003-1046-3650
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NR 44
TC 17
Z9 19
U1 0
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2013
VL 26
IS 11
BP 504
EP 510
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 298TF
UT WOS:000330346700005
PM 24149665
DA 2026-07-24
ER
PT J
AU Karr, JC
   de Mola, FL
   Pham, T
   Tooke, L
AF Karr, Jeffrey C.
   de Mola, Fernando Loret
   Tri Pham
   Tooke, Leslie
TI Wound Healing and Cost-Saving Benefits of Combining Negative-Pressure
   Wound Therapy with Silver
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; wound healing and silver; cost savings
ID VACUUM-ASSISTED CLOSURE; TRIAL
AB A 20-patient case series is presented, demonstrating the incorporation of a silver antimicrobial negative-pressure dressing and a negative-pressure wound therapy device for improved healing outcomes, decreased nursing time expenditure, and decreased cost expenditure.
C1 [Karr, Jeffrey C.; de Mola, Fernando Loret; Tri Pham; Tooke, Leslie] Lakeland Reg Med Ctr, Wound Care Ctr, Lakeland, FL 33805 USA.
RP Karr, JC (通讯作者)，Lakeland Reg Med Ctr, Wound Care Ctr, Lakeland, FL 33805 USA.
CR Barrows Christina, 2009, Home Healthc Nurse, V27, P279
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Carson SN, 2005, WOUNDS, V17, P282
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   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 8
TC 8
Z9 8
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD DEC
PY 2013
VL 26
IS 12
BP 562
EP 565
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 298TS
UT WOS:000330348000006
PM 24253213
DA 2026-07-24
ER
PT J
AU Kaufman-Rivi, D
   Hazlett, AC
   Hardy, MA
   Smith, JM
   Seid, HB
AF Kaufman-Rivi, Diana
   Hazlett, Antoinette C.
   Hardy, Mary Anne
   Smith, Jacquelyn M.
   Seid, Heather B.
TI Provider Experiences with Negative-Pressure Wound Therapy Systems
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative-pressure wound therapy; wound care; medical device reports;
   wound management
AB OBJECTIVE: MedWatch, the Food and Drug Administration's (FDA's) nationwide adverse event reporting system, serves to monitor device performance after a medical device is approved or cleared for market. Through the MedWatch adverse event reporting system, the FDA receives Medical Device Reports of deaths and serious injuries with negative-pressure wound therapy (NPWT) systems, many of which are used in homes and in extended-care facilities. In response to reported events, this study was conducted to obtain additional information about device issues that healthcare professionals face in these settings, as well as challenges that caregivers might encounter using this technology at home. The study was exploratory and descriptive in nature.
   PARTICIPANTS: The FDA surveyed wound care specialists and professional home healthcare providers to learn about users' experiences with NPWT.
   DESIGN: In the first phase of the study, a semistructured questionnaire was developed for telephone interviews and self-administration. In the second phase, a web-based survey was adapted from the semistructured instrument.
   RESULTS: Respondent concerns primarily centered on issues not directly related to the NPWT devices: NPWT prescription, provider education in addition to patient training and appropriate wound management practices, notably ongoing wound assessment, and patient monitoring.
   CONCLUSION: Overall, respondents thought that there was a definite benefit to NPWT, regardless of the care setting, and that it was a safe therapy when prescribed and administered appropriately.
C1 [Kaufman-Rivi, Diana; Hazlett, Antoinette C.] US FDA, Ctr Devices & Radiol Hlth, Off Surveillance & Biometr, Div Patient Safety Partnerships, Silver Spring, MD 20993 USA.
   [Hardy, Mary Anne] Montgomery Hlth Advocates LLC, Derwood, MD USA.
   [Smith, Jacquelyn M.; Seid, Heather B.] Social & Sci Syst Inc, Silver Spring, MD USA.
C3 US Food & Drug Administration (FDA); Social & Scientific Systems
RP Kaufman-Rivi, D (通讯作者)，US FDA, Ctr Devices & Radiol Hlth, Off Surveillance & Biometr, Div Patient Safety Partnerships, Silver Spring, MD 20993 USA.
FU Food and Drug Administration; Social & Scientific Systems, Inc for
   Medical Product Safety Network Activities
FX The authors acknowledge the members of the Food and Drug Administration
   Center for Devices and Radiological Health Workgroup, who throughout the
   project provided excellent analytic, scientific, and clinical expertise.
   Special thanks to study participants and to the professional
   organizations who worked with the Food and Drug Administration and
   Social & Scientific Systems, Inc on this effort, as well as all other
   stakeholders that the authors have collaborated with and will continue
   to work with in the future to ensure the safe use of negative-pressure
   wound therapy. This survey was funded under the Food and Drug
   Administration contract with Social & Scientific Systems, Inc for
   Medical Product Safety Network Activities. Submitted June 27, 2012;
   accepted in revised form October 23, 2012.
CR [Anonymous], 2024, MedWatch: The FDA safety information and adverse event reporting program
   [Anonymous], 2015, Overview of Device Regulation
   [Anonymous], 2009, TECHN ASS REP
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   Shirakawa M, 2005, ARCH DERMATOL, V141, P1449, DOI 10.1001/archderm.141.11.1449
   Thompson G, 2008, BR J COMMUNITY NURS, V13, pS26
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   Thompson Geoff, 2008, Br J Community Nurs, V13, pS23
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   US Food and Drug Administration, Premarket Notification 510(k)
   US Food and Drug Administration. Center for Devices and Radiological Health, PROD CLASS NEG PRESS
   US Food and Drug Administration. Center for Devices and Radiological Health, 2009, ADV PAT SER COMPL NE
   US Food and Drug Administration. Center for Devices and Radiological Health, MEDSUN MED PROD SAF
   US Food and Drug Administration (FDA), 2009, SER COMPL ASS NEG PR
   US Food and Drug Administration (FDA). Center for Devices and Radiological Health, MEDWATCH FORM FDA 35
   World Union of Wound Healing Societies, PRINC BEST PRACT VAC
NR 24
TC 5
Z9 5
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUL
PY 2013
VL 26
IS 7
BP 311
EP 318
DI 10.1097/01.ASW.0000431962.90766.2e
PG 8
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 299YL
UT WOS:000330431500004
PM 23777881
DA 2026-07-24
ER
PT J
AU Chang, EI
   Festekjian, JH
   Miller, TA
   Ardehali, A
   Rudkin, GH
AF Chang, Eric I.
   Festekjian, Jaco H.
   Miller, Timothy A.
   Ardehali, Abbas
   Rudkin, George H.
TI Chest Wall Reconstruction for Sternal Dehiscence After Open Heart
   Surgery
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE sternal dehiscence; poststernotomy mediastinitis; chest wall
   reconstruction
ID VACUUM-ASSISTED CLOSURE; GREATER OMENTUM; WOUND COMPLICATIONS;
   STERNOTOMY WOUNDS; TRANSPOSITION; MEDIASTINITIS; MANAGEMENT; FLAP;
   IRRIGATION; INFECTION
AB Background: Sternal dehiscence is a grave complication after open heart surgery. Sternal debridement and flap coverage are the mainstays of therapy, but no consensus exists regarding the appropriate level of debridement. More recently, the use of vacuum-assisted closure devices has been advocated as a bridge to definitive closure, but indications for use remain incompletely defined.
   Materials and Methods: A retrospective review of all chest wall reconstructions performed from January 2000 to December 2010 was conducted. The type of operative management was evaluated to assess morbidity, mortality, and length of hospital stay.
   Results: Fifty-four patients underwent chest wall reconstruction for post-sternotomy mediastinitis. Of these patients, 24 underwent conservative sternal debridement with flap closure, 24 underwent radical sternectomy including resection of the costal cartilages followed by flap closure, and 6 underwent radical sternectomy with vacuum-assisted closure therapy followed by flap closure in a delayed fashion. There were 15 patients in the conservative group and 8 patients in the radical sternectomy group who developed postoperative complications (62.5% vs 33.3%, P < 0.05). The conservative sternectomy group had more serious complications requiring reoperation compared to the radical sternectomy group (86.7% vs 25.0%, P < 0.05). The most common complication in the former group was flap dehiscence (8/15, 53.3%), whereas that in the latter group was a superficial wound infection (6/8, 75.0%). There was no significant difference in mortality (25.0% vs 25.0%, P > 0.05%) or length of hospital stay.
   Conclusions: Radical sternectomy including the costal cartilages is associated with lower rates of surgical morbidity and reoperation, but not mortality.
C1 [Chang, Eric I.; Festekjian, Jaco H.; Miller, Timothy A.; Rudkin, George H.] Univ Calif Los Angeles, Med Ctr, Div Plast & Reconstruct Surg, Los Angeles, CA 90095 USA.
   [Ardehali, Abbas] Univ Calif Los Angeles, Med Ctr, Div Cardiothorac Surg, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center
RP Rudkin, GH (通讯作者)，Univ Calif Los Angeles, Med Ctr, Div Plast & Reconstruct Surg, 200 UCLA Med Plaza,Suite 465, Los Angeles, CA 90095 USA.
EM eichang@hotmail.com
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NR 33
TC 11
Z9 14
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUL
PY 2013
VL 71
IS 1
BP 84
EP 87
DI 10.1097/SAP.0b013e31824872d9
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 300EC
UT WOS:000330446200022
PM 23123614
DA 2026-07-24
ER
PT J
AU Condé-Green, A
   Chung, TL
   Holton, LH
   Hui-Chou, HG
   Zhu, Y
   Wang, H
   Zahiri, H
   Singh, DP
AF Conde-Green, Alexandra
   Chung, Thomas L.
   Holton, Luther H., III
   Hui-Chou, Helen G.
   Zhu, Yue
   Wang, Howard
   Zahiri, Hamid
   Singh, Devinder P.
TI Incisional Negative-Pressure Wound Therapy Versus Conventional Dressings
   Following Abdominal Wall Reconstruction A Comparative Study
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE incisional negative-pressure wound therapy; abdominal wall
   reconstruction; conventional dry gauze dressings; outcomes
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Background: Improvements in surgical techniques have allowed us to achieve primary closure in a high percentage of large abdominal hernia repairs. However, postoperative wound complications remain common. The benefits of negative-pressure wound therapy (NPWT) in the management of open abdominal wounds are well described in the literature. Our study investigates the effects of incisional NPWT after primary closure of the abdominal wall.
   Methods: A retrospective chart review was performed for the period between September 2008 and May 2011 to analyze the outcomes of patients treated postoperatively with incisional NPWT versus conventional dry gauze dressings. Patient information collected included history of abdominal surgeries, smoking status, and body mass index. Postoperative complications were analyzed using W 2 exact test and logistic regression analysis.
   Results: Fifty-six patients were included in this study; of them, 23 were treated with incisional NPWT, whereas 33 received conventional dressings. The rates of overall wound complications in groups I and II were 22% and 63.6%, respectively (P = 0.020). The rates of skin dehiscence were 9% and 39%, respectively (P = 0.014). Both outcomes achieved statistical significance. Rates of infection, skin and fat necrosis, seroma, and hernia recurrence were 4%, 9%, 0%, and 4% for group I and 6%, 18%, 12%, 9% for group II, respectively.
   Conclusions: This study suggests that incisional NPWT following abdominal wall reconstruction significantly improves rates of wound complication and skin dehiscence when compared with conventional dressings. Prospective, randomized, controlled studies are needed to further characterize the potential benefits of this therapy on wound healing after abdominal wall reconstruction.
C1 [Conde-Green, Alexandra; Chung, Thomas L.; Holton, Luther H., III; Hui-Chou, Helen G.; Singh, Devinder P.] Univ Maryland, Med Ctr, Div Plast Surg, Baltimore, MD 21201 USA.
   [Zhu, Yue; Zahiri, Hamid] Univ Maryland, Med Ctr, Dept Surg, Baltimore, MD 21201 USA.
   [Wang, Howard] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore
RP Condé-Green, A (通讯作者)，Univ Maryland, Med Ctr, Div Plast Surg, Room S8D18,22 South Greene St, Baltimore, MD 21201 USA.
EM acondegreen@yahoo.com
RI Hui-Chou, Helen/AHE-3492-2022; Singh, Devinder/AAN-4716-2021
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 19
TC 118
Z9 144
U1 1
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2013
VL 71
IS 4
BP 394
EP 397
DI 10.1097/SAP.0b013e31824c9073
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 300GX
UT WOS:000330453500017
PM 22868327
DA 2026-07-24
ER
PT J
AU de Leon, JM
AF de Leon, Jean M.
TI Novel Techniques Using Negative Pressure Wound Therapy for the
   Management of Wounds With Enterocutaneous Fistulas in a Long-term Acute
   Care Facility
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Enterocutaneous fistulas; Negative pressure wound therapy; VAC Therapy;
   Wounds; Wound healing
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; DRESSINGS
AB Patient status and wound condition are important factors to consider when developing an appropriate wound management plan. Comorbid conditions such as diabetes mellitus, obesity, and peripheral vascular disease affect wound healing, as do complications, such as fistulas and infections. This article describes 3 novel techniques, using negative pressure wound therapy with reticulated open-cell foam for managing patients with wounds containing an enterocutaneous fistula.
C1 [de Leon, Jean M.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center
RP de Leon, JM (通讯作者)，UT Southwestern Med Ctr, Dept Phys Med & Rehabil, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM jean.deleon@utsouthwestern.edu
CR [Anonymous], 2010, THER CLIN GUID REF S
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   BERRY SM, 1994, CURR PROB SURG, V31, P474
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NR 33
TC 5
Z9 5
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2013
VL 40
IS 5
BP 481
EP 488
DI 10.1097/WON.0b013e3182a21c08
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 300KA
UT WOS:000330461600008
PM 24448617
DA 2026-07-24
ER
PT J
AU Freeman, JJ
   Storto, DLP
   Berry-Cabán, CS
AF Freeman, Julie J.
   Storto, Dominic L. P.
   Berry-Caban, Cristobal S.
TI Repair of a Vesicocutaneous Fistula Using Negative-Pressure Wound
   Therapy and Urinary Diversion via a Nephrostomy Tube
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Bladder; Fistula; Negative pressure wound therapy; Vesicocutaneous
   fistula
AB BACKGROUND: This article describes an unusual case of a vesicocutaneous fistula in a patient with a history of radiation therapy and recent abdominal surgery.
   CASE: A 61-year-old woman was transferred to our acute care facility from a rehabilitation facility, with poor nutritional intake and a concern for urine draining from her wound. A nephrostomy tube was placed (she had only 1 functioning kidney) and negative-pressure wound therapy was used to close the fistula.
   CONCLUSION: Urinary diversion via a nephrostomy tube and negative-pressure wound therapy were used to successfully and safely close this vesicocutaneous fistula.
C1 [Freeman, Julie J.] Womack Army Med Ctr, Dept Nursing, Ft Bragg, NC USA.
   [Storto, Dominic L. P.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC USA.
   [Berry-Caban, Cristobal S.] Womack Army Med Ctr, Dept Res, Ft Bragg, NC USA.
C3 United States Department of Defense; United States Army; United States
   Department of Defense; United States Army; United States Department of
   Defense; United States Army
RP Freeman, JJ (通讯作者)，2209 Goldentree Way, Vienna, VA 22182 USA.
EM Julie.jacob.freeman@gmail.com
CR Banihani MN, 2009, SINGAP MED J, V50, pE336
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   Kim SB, 2009, CLIN ORTHOP SURG, V1, P176, DOI 10.4055/cios.2009.1.3.176
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   Kishore T A, 2005, Indian J Med Sci, V59, P265
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NR 17
TC 4
Z9 5
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2013
VL 40
IS 5
BP 536
EP 538
DI 10.1097/WON.0b013e3182a46549
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 300KA
UT WOS:000330461600014
PM 24448623
DA 2026-07-24
ER
PT J
AU Irkoren, S
   Sivrioglu, N
   Karaca, H
AF Irkoren, Saime
   Sivrioglu, Nazan
   Karaca, Huray
TI Rare Complication After VAC Therapy in the Treatment of Tissue Defect
   Due to Surgical Excision of Pilonidal Sinus
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE pilonidal sinus; negative pressure wound therapy; squamosal cell
   carcinoma; tissue defect; vacuum-assisted closure
ID PRESSURE WOUND THERAPY; DISEASE
AB BACKGROUND: Pilonidal sinus is frequently managed with surgical incision. If the wound is left open to heal by secondary intention, negative pressure wound therapy (NPWT) is often used to promote healing.
   CASE: We describe the case of a 60-year-old patient referred after excision of a pilonidal sinus, which was managed postoperatively with NPWT. Unfortunately, the patient developed squamous cell carcinoma, which was undetected postoperatively, as the dressing was left in place for 5 days.
   CONCLUSION: Guidelines for the use of NPWT should be followed, with dressing intervals at 2 to 3 days. Wounds managed by NPWT should be monitored carefully for malignancy at the time of dressing changes.
C1 [Irkoren, Saime; Sivrioglu, Nazan; Karaca, Huray] Adnan Menderes Univ, Dept Plast & Reconstruct Surg, Fac Med, Aydin, Turkey.
C3 Adnan Menderes University
RP Irkoren, S (通讯作者)，Adnan Menderes Univ, Fac Med Ctr 09100, Dept Plast & Reconstruct Surg, Aydin, Turkey.
EM saimeirkoren@hotmail.com
CR Baharestani MM, 2004, WOUNDS, p29S
   Chatzis I, 2009, EUR J DERMATOL, V19, P408, DOI 10.1684/ejd.2009.0705
   Citak M, 2010, ARCH ORTHOP TRAUM SU, V130, P1511, DOI 10.1007/s00402-010-1091-6
   Farrell D, 2011, J WOUND OSTOMY CONT, V38, P373, DOI 10.1097/WON.0b013e31821e5117
   Kiessling AH, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-16
   Malek MM, 2007, DIS COLON RECTUM, V50, P1475, DOI 10.1007/s10350-007-0267-9
   Nessar G, 2004, AM J SURG, V187, P300, DOI 10.1016/j.amjsurg.2003.11.012
NR 7
TC 2
Z9 3
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD NOV-DEC
PY 2013
VL 40
IS 6
BP 641
EP 643
DI 10.1097/WON.0b013e3182a9c2d9
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 300KB
UT WOS:000330461700016
PM 24202229
DA 2026-07-24
ER
PT J
AU Kim, PJ
   Attinger, CE
   Steinberg, JS
   Evans, KK
   Lehner, B
   Willy, C
   Lavery, L
   Wolvos, T
   Orgill, D
   Ennis, W
   Lantis, J
   Gabriel, A
   Schultz, G
AF Kim, Paul J.
   Attinger, Christopher E.
   Steinberg, John S.
   Evans, Karen K.
   Lehner, Burkhard
   Willy, Christian
   Lavery, Larry
   Wolvos, Tom
   Orgill, Dennis
   Ennis, William
   Lantis, John
   Gabriel, Allen
   Schultz, Gregory
TI Negative-Pressure Wound Therapy with Instillation: International
   Consensus Guidelines
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; MICROVASCULAR
   BLOOD-FLOW; DIABETIC FOOT ULCERS; IN-VITRO; SUBATMOSPHERIC PRESSURE;
   IRRIGATION TREATMENT; AERUGINOSA BIOFILMS; INSTILL(R) THERAPY; BACTERIAL
   COUNTS
AB Background: Negative-pressure wound therapy with instillation is increasingly utilized as an adjunct therapy for a wide variety of wounds. Despite its growing popularity, there is a paucity of evidence and lack of guidance to provide effective use of this therapy.
   Methods: A panel of experts was convened to provide guidance regarding the appropriate use of negative-pressure wound therapy with instillation. A face-to-face meeting was held where the available evidence was discussed and individual clinical experience with this therapy was shared. Follow-up communication among the panelists continued until consensus was achieved. The final consensus recommendations were derived through more than 80 percent agreement among the panelists.
   Results: Nine consensus statements were generated that address the appropriate use of negative-pressure wound therapy with instillation. The question of clinical effectiveness of this therapy was not directly addressed by the consensus panel.
   Conclusion: This document serves as preliminary guidelines until more robust evidence emerges that will support or modify these consensus recommendations.
C1 [Attinger, Christopher E.] Georgetown Univ Hosp, Dept Plast Surg, Washington, DC 20007 USA.
   Heidelberg Univ, Orthoped & Trauma Clin, Heidelberg, Germany.
   Mil Hosp Berlin, Dept Trauma Senior Surg & Orthoped Reconstruct Se, Berlin, Germany.
   Univ Texas Southwestern, Dept Plast Surg, Dallas, TX USA.
   Scottsdale Healthcare Osborn Med Ctr, Div Gen Surg, Scottsdale, AZ USA.
   Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA.
   Univ Illinois, Dept Clin Surg, Chicago, IL USA.
   Columbia Univ, Dept Surg, New York, NY USA.
   Southwest Washington Med Ctr, Dept Plast & Maxillofacial Surg, Vancouver, WA USA.
   Univ Florida, Dept Wound Res, Gainesville, FL USA.
C3 Georgetown University; Ruprecht Karls University Heidelberg; University
   of Texas System; University of Texas Southwestern Medical Center;
   Scottsdale Healthcare Osborn; Harvard University; Harvard Medical
   School; University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; Columbia University; State
   University System of Florida; University of Florida
RP Attinger, CE (通讯作者)，Georgetown Univ Hosp, Dept Plast Surg, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM cattinger@aol.com
RI Orgill, Dennis/H-7596-2019; Gabriel, Allen/AFK-3548-2022; /AAJ-3174-2021
OI Orgill, Dennis/0000-0002-8279-7310; Lavery,
   Lawrence/0000-0002-7920-9952; Evans, Karen/0000-0003-1056-2114; ,
   Paul/0000-0002-6186-6890
FU Kinetic Concepts, Inc. (San Antonio, Texas)
FX The consensus panel was hosted by MedStar Georgetown University Hospital
   through an unrestricted educational grant provided by Kinetic Concepts,
   Inc. (San Antonio, Texas). This unrestricted grant provided financial
   support for a face-to-face expert panel meeting to discuss the available
   peer-reviewed publications as well as participants' clinical experience
   with negative-pressure wound therapy with instillation. The authors are
   solely responsible for the contents of this article.
CR Allen D., 2014, Int Wound J
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   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
   Willy C, 2013, ANTISEPTICS SURG, P33
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   Wolvos Tom, 2004, Ostomy Wound Manage, V50, P56
NR 52
TC 76
Z9 98
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2013
VL 132
IS 6
BP 1569
EP 1579
DI 10.1097/PRS.0b013e3182a80586
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 300LQ
UT WOS:000330465800064
PM 24005370
DA 2026-07-24
ER
PT J
AU Georgakarakos, E
   Charalampidis, D
   Kakagia, D
   Georgiadis, GS
   Lazarides, MK
   Papanas, N
AF Georgakarakos, Efstratios
   Charalampidis, Dimitris
   Kakagia, Despoina
   Georgiadis, George S.
   Lazarides, Miltos K.
   Papanas, Nikolaos
TI Current Achievements With Topical Negative Pressure to Improve Wound
   Healing in Dehiscent Ischemic Stumps of Diabetic Patients: A Case Series
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE diabetes; granulation; ischemia; negative pressure treatment; wound
   healing
ID VACUUM-ASSISTED-CLOSURE; SUBATMOSPHERIC PRESSURE; HYPERBARIC-OXYGEN;
   THERAPY; FOOT; AMPUTATIONS; MULTICENTER; EXPRESSION; ULCER; FLUID
AB Negative pressure wound therapy has been increasingly used either as a primary or as an adjunctive therapeutic measure to treat a variety of recalcitrant wounds during the past years. It is thought to act by creating a local environment that promotes cell proliferation, angiogenesis, and granulation tissue formation, leading to accelerated wound healing to the point of spontaneous closure or reducing the wound size to facilitate significantly further surgical reconstruction. This case series presents our preliminary experience with the use of a Topical Negative Pressure system in the treatment of challenging ischemic wounds of diabetic patients. It aims to underscore its beneficial effects and explore its potential role in the management of ischemic amputated stumps to avoid ipsilateral re-amputation at a higher level.
C1 [Georgakarakos, Efstratios; Charalampidis, Dimitris; Georgiadis, George S.; Lazarides, Miltos K.] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Vasc Surg, Komotini, Greece.
   [Kakagia, Despoina] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Plast & Reconstruct Surg, Komotini, Greece.
   [Papanas, Nikolaos] Democritus Univ Thrace, Dept Internal Med 2, Outpatient Clin Diabet Foot, Komotini, Greece.
C3 Democritus University of Thrace; Democritus University of Thrace;
   Democritus University of Thrace
RP Georgakarakos, E (通讯作者)，Univ Hosp Alexandroupolis, Dept Vasc Surg, Alexandroupolis 68100, Greece.
EM efstratiosgeorg@gmail.com
RI Kakagia, Despoina/AAP-1202-2021; Lazarides, Miltos/K-9070-2019;
   Georgakarakos, Efstratios/AAP-2524-2021
OI Kakagia, Despoina/0000-0003-2107-6170; Lazarides,
   Miltos/0000-0003-3458-7412; 
CR [Anonymous], CURR VASC PHARM
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   Stechmiller JK, 2006, WOUND REPAIR REGEN, V14, P371, DOI 10.1111/j.1743-6109.2006.00134.x
   Stone PA, 2005, ANN VASC SURG, V19, P805, DOI 10.1007/s10016-005-7973-3
   Tiaka Elisavet K, 2012, Perspect Vasc Surg Endovasc Ther, V24, P37, DOI 10.1177/1531003512442093
   Tiaka EK, 2012, ANGIOLOGY, V63, P302, DOI 10.1177/0003319711416804
   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   Wu SC, 2010, J VASC SURG, V52, p59S, DOI 10.1016/j.jvs.2010.06.009
   Xie X, 2010, J WOUND CARE, V19, P488
NR 41
TC 9
Z9 10
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD JUN
PY 2013
VL 12
IS 2
SI SI
BP 138
EP 145
DI 10.1177/1534734613483769
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 301GE
UT WOS:000330520000008
PM 23667104
DA 2026-07-24
ER
PT J
AU Guerra, O
   Maclin, MM
AF Guerra, O.
   Maclin, M. M.
TI Non-crosslinked porcine-derived acellular dermal matrix for the
   management of complex ventral abdominal wall hernias: a report of 45
   cases
SO HERNIA
LA English
DT Article
DE Ventral abdominal wall hernias; Non-crosslinked intact porcine-derived
   acellular dermal matrix; Vacuum-assisted closure; Synthetic mesh;
   Biologic acellular dermal matrix; Strattice
ID TERM-FOLLOW-UP; INCISIONAL HERNIA; COMPONENT SEPARATION; REPAIR;
   RECONSTRUCTION; OUTCOMES; LAPAROTOMY
AB Ventral abdominal wall hernias are common and repair is frequently associated with complications and recurrence. Although non-crosslinked intact porcine-derived acellular dermal matrix (PADM) has been used successfully in the repair of complex ventral hernias, there is currently no consensus regarding the type of mesh and surgical techniques to use in these patients. This report provides added support for PADM use in complex ventral hernias.
   In a consecutive series of adult patients (2008-2011), complex ventral abdominal wall hernias (primary and incisional) were repaired with PADM by a single surgeon. Patient comorbidities, repair procedures, and postoperative recovery, recurrence, and complications were noted.
   Forty-four patients (mean age, 57.5 years) underwent 45 single-stage ventral abdominal wall hernia repairs (3 primary; 42 incisional). Previously placed synthetic mesh was removed in 17 cases. In 40 cases, primary fascial closure was achieved; in 5 cases, PADM was used as a bridge. Vacuum-assisted closure (VAC) was used for 38/45 cases: 19 closed incisions, 16 cases using the "French fry" technique, and 3 cases with open incisions. Mean hospital stay was 8.2 days (range, 3-32) and mean follow-up was 17 months (range, 1-48). There were 4 (8.9 %) hernia recurrences, 3 requiring additional repair and 1 requiring PADM explantation. There were 3 (6.7 %) skin dehiscences, 4 (8.9 %) deep wound infections requiring drainage, and 5 (11.1 %) seromas (4 self-limited, 1 requiring drainage).
   Non-crosslinked intact PADM yielded favorable early outcomes when used to repair complex ventral abdominal wall hernias in high-risk patients.
C1 [Guerra, O.] Suburban Surg Associates, St Louis, MO 63141 USA.
   [Maclin, M. M.] Parkcrest Plast Surg, St Louis, MO USA.
RP Guerra, O (通讯作者)，Suburban Surg Associates, 555 N New Ballas Rd,Ste 265, St Louis, MO 63141 USA.
EM omarg@ssainc.net
FU LifeCell Corp., Branchburg, NJ
FX This was an Institutional Review Board-approved retrospective cohort
   study. Editorial support for this article was provided by Peloton
   Advantage, LLC, Parsippany, NJ, and funded by LifeCell Corp.,
   Branchburg, NJ. Dr. Guerra is a consultant for LifeCell Corp. and KCI.
   Dr. Maclin is a consultant for KCI, LifeCell Corp. and Cook Medical.
CR [Anonymous], ANN PLAST SURG
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NR 21
TC 13
Z9 14
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD FEB
PY 2014
VL 18
IS 1
BP 71
EP 79
DI 10.1007/s10029-013-1148-x
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 304BK
UT WOS:000330720000009
PM 23934355
OA hybrid
DA 2026-07-24
ER
PT J
AU Salman, AE
   Yetisir, F
   Aksoy, M
   Tokaç, M
   Yildirim, MB
   Kiliç, M
AF Salman, A. E.
   Yetisir, F.
   Aksoy, M.
   Tokac, M.
   Yildirim, M. B.
   Kilic, M.
TI Use of dynamic wound closure system in conjunction with vacuum-assisted
   closure therapy in delayed closure of open abdomen
SO HERNIA
LA English
DT Article
DE Severe sepsis; Fascia; Abdomen
ID FASCIAL CLOSURE; MANAGEMENT
AB Definitive abdominal closure may not be possible for several days or weeks after laparotomy in damage-control surgery, abdominal compartment syndrome and intraabdominal sepsis, until the patient has stabilized. Vacuum-assisted closure (VAC therapy(A (R)), KCI, San Antonio, TX, USA) and abdominal re-approximation anchor system (ABRA, Canica, Almonte, Ontario, Canada) are novel techniques in delayed closure of open abdomen. Our aim is to present the use of these strategies in the management of 7 patients with open abdomen.
   Between August 2010 and December 2011, 7 patients with severe peritonitis were stabilized by laparotomy and treated with either ABRA system or ABRA system in conjunction with VAC dressing. VAC dressing applied to 4 patients initially and followed by ABRA. ABRA was applied alone to remaining 3 patients. Demographic data and patient characteristics, timing of VAC dressing and ABRA system were recorded. ICU and hospital stay and development of incisional hernia were also recorded. Stage of open abdomen, width of abdominal defect, extent to damage to fascia, and pressure sores were staged.
   The mean duration with VAC dressing before ABRA application was 18 days. The mean duration of ABRA application was 53 days. The average width of the abdominal defect was 18 cm. The average length of defect was 20.8 cm. Delayed primary abdominal closure was accomplished in 6 patients without further surgery. Incisional hernia with a small abdominal defect developed in 2 patients.
   Abdominal re-approximation anchor system and VAC dressing can be used separately or in conjunction with each other for closure of delayed open abdomen successfully.
C1 [Salman, A. E.] Etlik Res & Training Hosp, Dept Anesthesiol & Reanimat, Ankara, Turkey.
   [Yetisir, F.; Tokac, M.; Yildirim, M. B.; Kilic, M.] Etlik Res & Training Hosp, Dept Gen Surg, Ankara, Turkey.
   [Aksoy, M.] Ataturk Training & Res Hosp, Dept Anesthesiol & Reanimat, Ankara, Turkey.
C3 Ankara Etlik Ihtisas Egitim ve Arastirma Hastanesi; Ankara Etlik Ihtisas
   Egitim ve Arastirma Hastanesi; Ankara Etlik Ihtisas Egitim ve Arastirma
   Hastanesi
RP Salman, AE (通讯作者)，Etlik Res & Training Hosp, Dept Anesthesiol & Reanimat, Ankara, Turkey.
EM ebru.salman@gmail.com; drfahriyetisir@hotmail.com
RI ; TOKAÇ, MEHMET/AAA-9577-2021; AKSOY, SEI MUSTAFA/AAM-9773-2020;
   YILDIRIM, Murat Baki/AAP-6226-2021
OI yetisir, fahri/0000-0002-8216-1355; TOKAÇ, MEHMET/0000-0002-7278-0937;
   AKSOY, SEI MUSTAFA/0000-0003-3197-5655; YILDIRIM, Murat
   Baki/0000-0001-9176-1160
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   Dal A, 2006, CAN J PLAST SURG, V14, P233
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NR 16
TC 37
Z9 42
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD FEB
PY 2014
VL 18
IS 1
BP 99
EP 104
DI 10.1007/s10029-012-1008-0
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 304BK
UT WOS:000330720000012
PM 23108788
DA 2026-07-24
ER
PT J
AU Siegel, HJ
   Herrera, DF
   Gay, J
AF Siegel, Herrick J.
   Herrera, Diego F.
   Gay, Jason
TI Silver Negative Pressure Dressing With Vacuum-assisted Closure of
   Massive Pelvic and Extremity Wounds
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
ID COMPLICATIONS; INFECTIONS; MANAGEMENT; BACTERIA; EFFICACY; FUSION;
   TUMORS
AB Massive soft tissue loss involving the pelvis and extremities from trauma, infections, and tumors remains a challenging and debilitating problem. Although vacuum-assisted closure (VAC) technology is effective in the management of soft tissue loss, the adjunct of a silver dressing in the setting of massive wounds has not been as well tested.
   Does a silver negative pressure dressing used in conjunction with a wound VAC decrease (1) the length of acute hospital stay and overall length of treatment; (2) the number of surgical d,bridements the patients underwent as part of their care; and (3) the likelihood of wound closure without soft tissue transposition?
   We evaluated 42 patients with massive (> 200 cm(2)) pelvic and extremity wounds from trauma, infection, or tumor who were treated with the wound VAC with or without a silver negative pressure dressing between January 2003 and January 2010; the first 26 patients were treated with the wound VAC alone, and in the final 16 consecutively treated patients, the silver dressing was added to the regimen. We reviewed medical records to determine length of treatment as well as the number and type of surgical interventions these patients underwent. We compared the group treated with the wound VAC alone with those patients treated with the wound VAC and silver negative pressure dressing.
   Hospital stay averaged 19 days in the VAC only group and 7.5 days in the VAC with silver dressing group (p < 0.041), length of overall treatment averaged 33 days in the VAC only group and 14.3 days in the VAC with silver dressing group (p < 0.022), number of operative d,bridements averaged 7.9 in the VAC alone group and 4.1 in the VAC with silver dressing group (p < 0.001), and success of wound closure without soft tissue transposition was 16 of 26 patients in the VAC alone group and three of 16 patients in the VAC with silver dressing group (p < 0.033).
   Based on the reduced length of care and the number of surgical procedures these patients with massive wounds of the pelvis and extremities underwent, we now use the silver negative pressure dressing in combination with the wound VAC as part of routine care of such patients. These results may be used as hypothesis-generating data for future randomized studies.
   Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
C1 [Siegel, Herrick J.; Herrera, Diego F.] UAB, Sch Med, Dept Surg, Birmingham, AL 35305 USA.
   [Gay, Jason] UAB, Med Ctr, Orthopaed RNFA, Birmingham, AL 35305 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Siegel, HJ (通讯作者)，UAB, Sch Med, Dept Surg, Birmingham, AL 35305 USA.
EM hsiegel@uabmc.edu
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NR 33
TC 11
Z9 19
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-921X
EI 1528-1132
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD MAR
PY 2014
VL 472
IS 3
BP 830
EP 835
DI 10.1007/s11999-013-3123-3
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA AA3ET
UT WOS:000330976400011
PM 23813240
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Orgill, DP
   Bayer, LR
AF Orgill, Dennis P.
   Bayer, Lauren R.
TI Negative pressure wound therapy: past, present and future
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Negative pressure; NPWT; Subatmospheric pressure; VAC; Wound healing
ID VACUUM-ASSISTED CLOSURE; PROLIFERATION; FOUNDATION; TISSUE
AB Negative pressure wound therapy (NPWT), which was introduced as a commercial product (V.A.C.(R) Therapy, KCI USA, Inc., San Antonio, TX) less than 20 years ago, has revolutionised the treatment of complex wounds. Indicated for wide variety of wound types, NPWT is an adjunctive therapy that can be used safely in a range of care settings. Current research indicates that there are four primary NPWT mechanisms of action: macrodeformation, microdeformation, fluid removal and environmental control of the wound. The interaction of the primary mechanisms results in secondary effects through cell signalling (e.g. granulation tissue formation, cell proliferation and modulation of inflammation). Better understanding of the mechanisms of action also provides insight into future directions for NPWT research that could create better solutions for patients with complex wounds.
C1 [Orgill, Dennis P.; Bayer, Lauren R.] Harvard Univ, Brigham & Womens Hosp, Div Plast Surg, Sch Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019
FU Kinetic Concepts, Inc. (KCI); KCI
FX Dr. David P Orgill presented as a faculty member during the 2013
   International Surgical Wound Forum (ISWF), an annual educational event
   sponsored by Kinetic Concepts, Inc. (KCI). His article is part of a
   KCI-funded educational supplement based on faculty presentations at 2012
   and 2013 ISWF sessions related to wound care strategies with a focus on
   use of negative pressure wound therapy with instillation (i.e. VA.C.
   Instill (R) Wound Therapy and V.A.C. VeraFlo (TM) Therapy, KCI, San
   Antonio, TX). KCI assisted with editorial review of the manuscript.
   Lauren R Bayer states no conflict of interest or financial relationship
   with KCI.
CR [Anonymous], 2010, VAC THER CLIN GUID R
   [Anonymous], 2012, 2012 WOUND CARE PROD
   [Anonymous], 2011, 2011 WOUND CARE PROD
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 18
TC 136
Z9 170
U1 0
U2 29
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2013
VL 10
SU 1
SI SI
BP 15
EP 19
DI 10.1111/iwj.12170
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AA3GG
UT WOS:000330980300004
PM 24251839
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Rycerz, AM
   Allen, D
   Lessing, MC
AF Rycerz, Anthony M.
   Allen, Diwi
   Lessing, M. Christian
TI Science supporting negative pressure wound therapy with instillation
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Negative pressure wound therapy; Negative pressure wound therapy with
   instillation; Periodic instillation; Reticulated open-cell foam; Wound
   cleansing
ID VACUUM-ASSISTED CLOSURE
AB A new method (V.A.C.ULTA (TM) Therapy System, KCI USA, Inc., San Antonio, TX) combines the benefits of negative pressure wound therapy (NPWT; V.A.C.(R) Therapy, KCI USA, Inc.) with regulated, periodic instillation of user-selected topical wound solutions (V.A.C. VeraFlo (TM) Therapy, KCI USA, Inc.). In simulated wound model studies comparing solution distribution using NPWT with and without a soak phase, the instillation soak phase allowed for uniform solution distribution across the wound bed, whereas continuous (no soak) irrigation resulted in uneven coverage. Additional in vitro work illustrated that bacterial particle aerosolisation during wound cleansing was significantly decreased using NPWT with instillation (NPWTi) versus commercially available low-pressure wound cleansers (P < 0.05). In porcine studies, NPWT with saline instillation induced 43% more granulation tissue versus NPWT (P < 0.05) and was as effective at wound cleansing as pulsed lavage. These studies have demonstrated that NPWTi may be an effective wound management therapy that provides both wound cleansing and NPWT benefits.
C1 [Rycerz, Anthony M.; Allen, Diwi; Lessing, M. Christian] Kinet Concepts Inc, San Antonio, TX 78249 USA.
RP Rycerz, AM (通讯作者)，Kinet Concepts Inc, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM anthony.rycerz@kci1.com
OI Lessing, Chris/0009-0001-5009-6624
FU Kinetic Concepts, Inc. (KCI); KCI
FX All authors (AMR, DA and MCL) are employees of Kinetic Concepts, Inc.
   (KCI). Drs AMR and MCL presented as a faculty members during the
   International Surgical Wound Forum (ISWF), an annual educational event
   sponsored by Kinetic Concepts, Inc. (KCI). This article is part of a
   KCI-funded educational supplement based on faculty presentations at 2012
   and 2013 ISWF sessions related to wound care strategies with a focus on
   use of negative pressure wound therapy with instillation (i.e. VA.C.
   Instill (R) Wound Therapy and V.A.C. VeraFlo (TM) Therapy, KCI, San
   Antonio, TX). The authors express special thanks to the KCI Research and
   Development Department and especially to Dr Amy McNulty and Dr Paul
   Slack for guidance and execution. They also thank reviewers
   (specifically Twan Wackers, Alice Goodwin and Dr Sandra Garcia) whose
   input is greatly appreciated.
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NR 18
TC 31
Z9 39
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2013
VL 10
SU 1
SI SI
BP 20
EP 24
DI 10.1111/iwj.12171
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AA3GG
UT WOS:000330980300005
PM 24251840
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Dalla Paola, L
AF Dalla Paola, Luca
TI Diabetic foot wounds: the value of negative pressure wound therapy with
   instillation
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Diabetic foot wounds; Instillation therapy; Negative pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; LOWER-LIMB AMPUTATIONS; MAJOR AMPUTATION;
   PERIPHERAL ANGIOPLASTY; DECREASING INCIDENCE; RISK-FACTORS; ULCERS;
   ULCERATION; CARE; MULTICENTER
AB Chronic wounds such as diabetic foot wounds are a tremendous burden to the health care system and often require a multidisciplinary approach to prevent amputations. Advanced technologies such as negative pressure wound therapy (NPWT) and bioengineered tissues have been successfully used in the treatment of these types of complex wounds. However, the introduction of NPWT with instillation (NPWTi) has provided an alternative treatment for treating complex and difficult-to-heal wounds. This article provides an overview of NPWT and the new NPWTi system and describes preliminary experience using NPWTi on patients with complicated infected diabetic foot wounds after surgical debridement and in a multidisciplinary setting.
C1 [Dalla Paola, Luca] Maria Cecilia Hosp, Diabet Foot Unit, I-48010 Cotignola, RA, Italy.
C3 Maria Cecilia Hospital
RP Dalla Paola, L (通讯作者)，Maria Cecilia Hosp, Diabet Foot Unit, Diabet Foot Dept, GVM Care & Res, Via Corriera 1, I-48010 Cotignola, RA, Italy.
EM ldallapaola@libero.it
FU Kinetic Concepts, Inc. (KCI); KCI
FX Dr LDP presented as a faculty member during the 2012 International
   Surgical Wound Forum (ISWF), an annual educational event sponsored by
   Kinetic Concepts, Inc. (KCI). His article is part of a KCI-funded
   educational supplement based on faculty presentations at 2012 and 2013
   ISWF sessions related to wound care strategies with a focus on use of
   negative pressure wound therapy with instillation (i.e. V.A.C. Instill
   (R) Wound Therapy and V.A.C. VeraFlo (TM) Therapy; KCI, San Antonio,
   TX). KCI assisted with editorial review of the manuscript.
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NR 63
TC 27
Z9 28
U1 0
U2 46
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2013
VL 10
SU 1
SI SI
BP 25
EP 31
DI 10.1111/iwj.12174
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AA3GG
UT WOS:000330980300006
PM 24251841
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Back, DA
   Scheuermann-Poley, C
   Willy, C
AF Back, David A.
   Scheuermann-Poley, Catharina
   Willy, Christian
TI Recommendations on negative pressure wound therapy with instillation and
   antimicrobial solutions - when, where and how to use: what does the
   evidence show?
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Antiseptics; Contamination; Instillation; Negative pressure wound
   therapy; Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; IN-VITRO MODEL; IRRIGATION TREATMENT; VAC(TM)
   INSTILLATION; INFECTED WOUNDS; PROXIMAL FEMUR; OPEN FRACTURE;
   PREVENTION; HIP; POLIHEXANIDE
AB Infections of contaminated or colonised acute or chronic wounds remain a grave risk for patients even today. Despite modern surgical debridement concepts and antibiotics, a great need exists for new therapies in wound management. Since the late 1990s, advantageous effects of negative pressure wound therapy (NPWT) have been combined with local antiseptic wound cleansing in the development of NPWT with instillation (NPWTi). This article summarises the current scientific knowledge on this topic. MEDLINE literature searches were performed on the subject of negative pressure wound and instillation therapy covering publications from the years 1990 to 2013 (36 peer-reviewed citations) and regarding randomised controlled trials (RCTs) covering wound care with bone involvement (27 publications) or soft-tissue wounds without bone participation (11 publications) from 2005 to 2012. The use of NPWTi in the therapy of infected wounds appears to be not yet widespread, and literature is poor and inhomogeneous. However, some reports indicate an outstanding benefit of NPWTi for patients, using antiseptics such as polyhexanide (concentration 0.005-0.04%) and acetic acid (concentration 0.25-1%) in acute and chronic infected wounds and povidone-iodine (10% solution) as prophylaxis in contaminated wounds with potential viral infection. Soaking times are recommended to be 20 minutes each, using cycle frequencies of four to eight cycles per day. Additionally, the prophylactic use of NPWTi with these substances can be recommended in contaminated wounds that cannot be closed primarily with surgical means. Although first recommendations may be given currently, there is a great need for RCTs and multicentre studies to define evidence-based guidelines for an easier approach to reach the decision on how to use NPWTi.
C1 [Back, David A.; Scheuermann-Poley, Catharina; Willy, Christian] Bundeswehrkrankenhaus Berlin, Dept Traumatol & Orthoped, D-10115 Berlin, Germany.
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Berlin, Colonel Dept Traumatol & Orthoped, Scharnhorststr 13, D-10115 Berlin, Germany.
EM christianwilly@bundeswehr.org
OI Back, David Alexander/0000-0001-7552-7753
FU Kinetic Concepts, Inc. (KCI); KCI
FX Dr CW presented as a faculty member during the 2012 and 2013
   International Surgical Wound Forum (ISWF), an annual educational event
   sponsored by Kinetic Concepts, Inc. (KCI). He is the guest editor for
   this KCI-funded educational supplement based on faculty presentations at
   2012 and 2013 ISWF sessions related to wound care strategies with a
   focus on use of negative pressure wound therapy with instillation (i.e.
   V.A.C. Instill (R) Wound Therapy and V.A.C. VeraFlo (TM) Therapy; KCI,
   San Antonio, TX). KCI assisted with editorial review of manuscript. Dr
   DAB and Dr CSP report no conflict of interests or financial relationship
   with KCI.
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NR 83
TC 64
Z9 81
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2013
VL 10
SU 1
SI SI
BP 32
EP 42
DI 10.1111/iwj.12183
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AA3GG
UT WOS:000330980300007
PM 24251842
OA Green Accepted, Bronze
DA 2026-07-24
ER
PT J
AU Phillips, PL
   Yang, QP
   Schultz, GS
AF Phillips, Priscilla L.
   Yang, Qingping
   Schultz, Gregory S.
TI The effect of negative pressure wound therapy with periodic instillation
   using antimicrobial solutions on Pseudomonas aeruginosa biofilm
   on porcine skin explants
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Irrigation; pDADMAC; PHMB; PVP-I; Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; INSTILL(R) THERAPY; CASE SERIES; LEG ULCERS;
   INFECTIONS; INJURIES; OSTEOMYELITIS
AB Negative pressure wound therapy with instillation (NPWTi) is increasingly used as an adjunct therapy for a wide variety of infected wounds. However, the effect of NPWTi on mature biofilm in wounds has not been determined. This study assessed the effects of NPWTi using saline or various antimicrobial solutions on mature Pseudomonas aeruginosa biofilm using an ex vivo porcine skin explant biofilm model. Treatment consisted of six cycles with 10-minute exposure to instillation solution followed by 4 hours of negative pressure at -125 mm Hg over a 24-hour period. NPWTi using saline reduced bacterial levels by 1-log (logarithmic) of 7-log total colony-forming units (CFUs). In contrast, instillation of 1% povidone iodine (2-log), L-solution (3-log), 0.05% chlorhexidine gluconate (3-log), 0.1% polyhexamethylene biguanide (4-log), 0.2% polydiallyldimethylammonium chloride (4-log) and 10% povidone iodine (5-log), all significantly reduced (P < 0.001) total CFUs. Scanning electron micrographs showed disrupted exopolymeric matrix of biofilms and damaged bacterial cells that correlated with CFU levels. Compared with previous studies assessing microbicidal effects of topical antimicrobial dressings on biofilms cultured on porcine skin explants, these ex vivo model data suggest that NPWTi with delivery of active antimicrobial agents enhances the reduction of CFUs by increasing destruction and removal of biofilm bacteria. These results must be confirmed in human studies.
C1 [Phillips, Priscilla L.; Yang, Qingping; Schultz, Gregory S.] Univ Florida, Dept Obstet & Gynecol, Inst Wound Res, Gainesville, FL 32611 USA.
C3 State University System of Florida; University of Florida
RP Phillips, PL (通讯作者)，POB 100424, Gainesville, FL 32610 USA.
EM prislp@ufl.edu
OI Phillips, Priscilla/0000-0001-7917-7703
FU Kinetic Concepts, Inc. (KCI); KCI
FX Dr GSS presented as a faculty member during the 2012 International
   Surgical Wound Forum (ISWF), an annual educational event sponsored by
   Kinetic Concepts, Inc. (KCI). His article is part of a KCI-funded
   educational supplement based on faculty presentations at 2012 and 2013
   ISWF sessions related to wound care strategies with a focus on use of
   negative pressure wound therapy with instillation (i.e. V.A.C. Instill
   (R) Wound Therapy and V.A.C. VeraFlo (TM) Therapy; KCI, San Antonio,
   TX). KCI assisted with editorial review of the manuscript. Dr PLP and Ms
   QY state no conflict of interests or financial relationship with KCI.
   This study was funded by an unrestricted research grant from Kinetic
   Concepts, Inc. (KCI).
CR Amtsberg G, 2009, INFECTION, V37, P33
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NR 33
TC 72
Z9 88
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2013
VL 10
SU 1
SI SI
BP 48
EP 55
DI 10.1111/iwj.12180
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AA3GG
UT WOS:000330980300009
PM 24251844
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Brinkert, D
   Ali, M
   Naud, M
   Maire, N
   Trial, C
   Téot, L
AF Brinkert, David
   Ali, Mazen
   Naud, Magali
   Maire, Nicolas
   Trial, Chloe
   Teot, Luc
TI Negative pressure wound therapy with saline instillation: 131 patient
   case series
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Diabetic foot ulcers; Infection; Instillation therapy; Orthopaedic
   wounds
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; SYSTEM
AB Negative pressure wound therapy combined with timed, cyclical instillation (NPWTi) of topical wound solutions has been recently presented as a new adjunctive modality for treating wounds with signs of infection. Normal saline, antiseptics and antimicrobials all have been proposed in scientific and clinical studies as potentially effective when used with NPWTi for treating heavily infected wounds. This is a prospective clinical study of 131 patients with 131 wounds treated with NPWTi using saline between January 2012 and December 2012 in two orthopaedic centres and one surgical wound healing centre in France. Saline was exclusively used. Results were favourable: in 98% of the cases, the wounds could be closed after debridement and following the use of NPWTi. Mean duration of NPWTi was 12.19 days. This does not preclude the need for treating the biofilm appropriately with more active antibacterial products when biofilm has been documented.
C1 [Brinkert, David; Maire, Nicolas] Strasbourg Univ Hosp, Dept Orthoped, Strasbourg, France.
   [Ali, Mazen] Orleans Hosp, Orthoped Unit, Orleans, France.
   [Naud, Magali] Montpellier Univ Hosp, Coll Pharm, F-34090 Montpellier, France.
   [Trial, Chloe; Teot, Luc] Montpellier Univ Hosp, Wound Healing Unit, F-34090 Montpellier, France.
C3 Universites de Strasbourg Etablissements Associes; Universite de
   Strasbourg; CHU Strasbourg; Centre Hospitalier Universitaire d'Orleans;
   Universite de Montpellier; CHU de Montpellier; Universite de
   Montpellier; CHU de Montpellier
RP Téot, L (通讯作者)，Montpellier Univ Hosp, Pole EMMBRUN, 39 Ave Charles Flauhault, F-34090 Montpellier, France.
EM l-teot@chu-montpellier.fr
FU Kinetic Concepts, Inc. (KCI); KCI
FX Dr LT presented as a faculty member during the 2012 International
   Surgical Wound Forum (ISWF), an annual educational event sponsored by
   Kinetic Concepts, Inc. (KCI). His article is part of a KCI-funded
   educational supplement based on faculty presentations at 2012 and 2013
   ISWF sessions related to wound care strategies with a focus on use of
   negative pressure wound therapy with instillation (i.e. V.A.C. Instill
   (R) Wound Therapy and V.A.C. VeraFlo (TM) Therapy; KCI, San Antonio,
   TX). Karen Beach (KCI, Inc.) assisted with medical writing support. Drs
   DB, MN, NM and CT state no conflict of interests or financial
   relationship with KCI.
CR [Anonymous], OSTOMY WOUND MANAG S
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   Wolvos Tom, 2004, Ostomy Wound Manage, V50, P56
NR 22
TC 93
Z9 117
U1 1
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2013
VL 10
SU 1
SI SI
BP 56
EP 60
DI 10.1111/iwj.12176
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AA3GG
UT WOS:000330980300010
PM 24251845
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Pliakos, I
   Michalopoulos, N
   Papavramidis, TS
   Arampatzi, S
   Diza-Mataftsi, E
   Papavramidis, S
AF Pliakos, Ioannis
   Michalopoulos, Nikolaos
   Papavramidis, Theodossis S.
   Arampatzi, Stergiani
   Diza-Mataftsi, Eudoxia
   Papavramidis, Spiros
TI The Effect of Vacuum-Assisted Closure in Bacterial Clearance of the
   Infected Abdomen
SO SURGICAL INFECTIONS
LA English
DT Article
ID INTENSIVE-CARE-UNIT; GRAM-NEGATIVE BACILLI; SEVERE PERITONITIS;
   SURGICAL-PATIENTS; ABDOMINAL SEPSIS; LAPAROSTOMY; MANAGEMENT;
   RESISTANCE; STATES; SUSCEPTIBILITY
AB Background: Laparostomy with vacuum-assisted closure (VAC) plays an important role in improving survival in the presence of abdominal infection. We conducted a study of the qualitative changes in the bacterial flora of the peritoneal cavity in patients with severe abdominal infection treated with laparostomy and a VAC device. Methods: Thirty-nine patients with severe abdominal infection treated with abdominal opening and VAC were registered in a clinical study. When an incidence of 53.8% of hospital-acquired peritoneal infection (HAPI) was found in the study patient population, it was decided to divide the patients in two groups according to whether or not they developed a HAPI. The patients' outcomes were then analyzed. Results: The durations of abdominal opening (p=0.04), length of stay in the intensive care unit (ICU) (p=0.01), and of hospitalization (p=0.04) were significantly greater in patients with HAPI than in those without it, whereas mortality did not differ on the basis of these three variables. Conclusions: Superinfection is common in laparostomy done with a VAC device for managing severe abdominal infection. The data in the present study show that VAC does not alter the quality of the bacterial burden in primary abdominal contamination, nor does it seem to prevent a high incidence of HAPI. However, VAC is as effective in reducing mortality among patients with HAPI as among those without it.
C1 [Pliakos, Ioannis; Michalopoulos, Nikolaos; Papavramidis, Theodossis S.; Papavramidis, Spiros] Aristotle Univ Thessaloniki, Dept Surg 3, AHEPA Univ Hosp, GR-54006 Thessaloniki, Greece.
   [Arampatzi, Stergiani; Diza-Mataftsi, Eudoxia] Aristotle Univ Thessaloniki, Dept Microbiol 2, AHEPA Univ Hosp, GR-54006 Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital;
   Aristotle University of Thessaloniki; Ahepa University Hospital
RP Pliakos, I (通讯作者)，Lysimachou 3, Thessaloniki 54645, Greece.
EM plliakos@hotmail.com
RI Papavramidis, Theodossis/E-8260-2011; Michalopoulos, Nickos/I-6159-2013;
   Papavramidis, Theodossis/E-8260-2011
OI Papavramidis, Theodossis/0000-0002-7097-9889; Michalopoulos,
   Nickos/0000-0002-7740-4922; Papavramidis, Theodossis/0000-0002-7097-9889
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NR 36
TC 19
Z9 22
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD FEB 1
PY 2014
VL 15
IS 1
BP 18
EP 23
DI 10.1089/sur.2012.156
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA AA9BE
UT WOS:000331387900004
PM 24286126
DA 2026-07-24
ER
PT J
AU Zuo, HY
   Chen, Y
AF Zuo, H. Y.
   Chen, Y.
TI Retinervus luffae fructus (RLF): a novel material for use in negative
   pressure wound therapy
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE retinervus luffae fructus; negative pressure wound therapy; limb defects
ID VACUUM-ASSISTED CLOSURE; FLAP RECONSTRUCTION; CYLINDRICA; EPIDEMIOLOGY;
   MANAGEMENT; FRACTURES; INFECTION; EXTRACTS; DYE
AB Objective: To describe a modified negative pressure wound therapy, (NPWT) apparatus, made mainly of an environmentally-friendly material derived from the retinervus luffae fructus (RLF; or loofah) plant.
   Method: We retrospectively reviewed the charts of patients with skin defects on their limbs who underwent treatment with the RLF-NPWT device from September 2012 to October 2012.The endpoint of the study was healing by secondary intention; the time (days) to endpoint was evaluated.
   Results: The RLF-NPWT device was used in 16 patients.The age of the patients ranged from 15-82 years, with a mean age of 43 +/- 17 years. Six patients sustained crush injuries, nine patients had open limb injuries from motor vehicle accidents and a further patient had a diabetic foot ulcer.The mean time to healing was 8.5 +/- 2.4 days. Following RLF-NPWT, fresh granulation tissue was observed in all wound beds, with no evidence of macroscopical necrosis.All 16 patients in the study achieved secondary healing.
   Conclusion: The environmentally friendly RLF-NPWT apparatus is easy to use and able to provide continual negative pressure for optimal preparation of the wound bed.The cost-effectiveness of RLF-NPWT compared to standard NPWT requires further investigation.
C1 [Zuo, H. Y.; Chen, Y.] Jinling Gen Hosp, Dept Orthopaed, Nanjing, Jiangsu, Peoples R China.
RP Zuo, HY (通讯作者)，Jinling Gen Hosp, Dept Orthopaed, Nanjing, Jiangsu, Peoples R China.
EM 13813889089@139.com
OI zuo, yanhai/0000-0002-9103-6791
CR Abirami MS., 2011, PHARMACOLOGYONLINE, V3, P281
   Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Altinisik A, 2010, J HAZARD MATER, V179, P658, DOI 10.1016/j.jhazmat.2010.03.053
   Banerjee M, 2013, INJURY, V44, P1015, DOI 10.1016/j.injury.2012.12.007
   Bickels J, 2005, CLIN ORTHOP RELAT R, P346, DOI 10.1097/01.blo.0000180450.21350.3e
   Byrnside V, 2010, J ORAL MAXIL SURG, V68, P935, DOI 10.1016/j.joms.2009.09.113
   Court-Brown CM, 1998, INJURY, V29, P529, DOI 10.1016/S0020-1383(98)00125-9
   Culliford AT, 2007, J PLAST RECONSTR AES, V60, P99, DOI 10.1016/j.bjps.2006.03.070
   Demir H, 2008, J HAZARD MATER, V153, P389, DOI 10.1016/j.jhazmat.2007.08.070
   Durai R, 2010, INT J CLIN PRACT, V64, P93, DOI 10.1111/j.1742-1241.2009.02007.x
   Gill NA, 2011, WOUNDS, V23, P84
   Hou ZY, 2011, J TRAUMA, V71, P1705, DOI 10.1097/TA.0b013e31822e2823
   Ibrahim MA, 2011, INDIAN J EXP BIOL, V49, P552
   Impellizzeri P, 2011, J VASC SURG, V54, P1154, DOI 10.1016/j.jvs.2011.03.300
   Jiang N, 2010, INT J AGRIC BIOL, V12, P205
   Kakarala K, 2011, ARCH OTOLARYNGOL, V137, P622, DOI 10.1001/archoto.2011.74
   Katz MS, 2012, J PEDIATR SURG, V47, P367, DOI 10.1016/j.jpedsurg.2011.11.030
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   Leffler M, 2010, J PLAST RECONSTR AES, V63, pE32, DOI 10.1016/j.bjps.2009.05.022
   Liu LL, 2010, ACTA BIOCH BIOPH SIN, V42, P585, DOI 10.1093/abbs/gmq056
   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
   Ng YM, 2011, J STRUCT BIOL, V174, P164, DOI 10.1016/j.jsb.2010.12.007
   Oboh IO, 2009, AFR J AGR RES, V4, P684
   Ploumis A, 2008, J SPINAL DISORD TECH, V21, P320, DOI 10.1097/BSD.0b013e318141f99d
   Reed SF, 2008, J TRAUMA, V64, P1406, DOI 10.1097/TA.0b013e318150733c
   Riebe E, 2010, INT J GYNECOL CANCER, V20, P179, DOI 10.1111/IGC.0b013e3181c13343
   Satsu T, 2010, PACE, V33, P426, DOI 10.1111/j.1540-8159.2009.02661.x
   Shaheed A, 2009, ENVIRON TECHNOL, V30, P1435, DOI 10.1080/09593330903193485
   Tocco MP, 2009, EUR J CARDIO-THORAC, V35, P833, DOI 10.1016/j.ejcts.2008.12.036
   Webster R, 2011, PLAST RECONSTR SURG, V128, p784E, DOI 10.1097/PRS.0b013e318230be64
   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Wood T, 2012, J TRAUMA ACUTE CARE, V72, P1078, DOI 10.1097/TA.0b013e31823fb06b
   Zhang LW, 2012, WATER SCI TECHNOL, V65, P190, DOI 10.2166/wst.2011.846
NR 33
TC 1
Z9 1
U1 0
U2 9
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2014
VL 23
IS 2
BP 81
EP 87
DI 10.12968/jowc.2014.23.2.81
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AB6RN
UT WOS:000331917300009
PM 24526084
DA 2026-07-24
ER
PT J
AU Trevino, CM
   Verhaalen, A
   Bruce, ML
   Webb, T
AF Trevino, Colleen M.
   Verhaalen, Amy
   Bruce, Marie L.
   Webb, Travis
TI Conversion of an Enterocutaneous Fistula Associated With an Open
   Abdominal Wound Into a Drain-Controlled Enterocutaneous Fistula
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE enterocutaneous fistula; cutaneous fistula; fistula isolation
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Open abdominal wounds with enterocutaneous fistulae present health care providers and patients with complex wound management issues. Frequently, large wounds with exposed bowel are present and require the utilization of multiple wound care modalities to provide a method of control and isolation of fistula effluent to allow for maximum wound healing. This case study presents a unique approach to management of low-output enterocutaneous fistula with an open abdominal wound. Through the use of negative pressure wound therapy, a standard surgical drain, and optimized nutrition, fistula drainage was redirected and the abdominal wound healed, leaving a drain-controlled enterocutaneous fistula.
C1 [Trevino, Colleen M.; Verhaalen, Amy; Bruce, Marie L.; Webb, Travis] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Trevino, CM (通讯作者)，Med Coll Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
EM ctrevino@mcw.edu
OI Trevino, Colleen/0000-0002-7813-3642
CR European Wound Management Association, 2007, POS DOC TOP NEG PRES
   Heller L, 2006, AM J SURG, V191, P165, DOI 10.1016/j.amjsurg.2005.09.003
   Ichioka S, 2008, WOUND REPAIR REGEN, V16, P460, DOI 10.1111/j.1524-475X.2008.00390.x
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Schecter WP, 2006, J AM COLL SURGEONS, V203, P390, DOI 10.1016/j.jamcollsurg.2006.06.001
   Schecter WP, 2009, J AM COLL SURGEONS, V209, P484, DOI 10.1016/j.jamcollsurg.2009.05.025
   Verhaalen AL, 2006, GEN SURG NEWS, V33
NR 7
TC 1
Z9 2
U1 1
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2014
VL 26
IS 2
BP 43
EP 46
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AB6VL
UT WOS:000331927500003
PM 25860225
DA 2026-07-24
ER
PT J
AU Fortelny, RH
   Hofmann, A
   Gruber-Blum, S
   Petter-Puchner, AH
   Glaser, KS
AF Fortelny, Rene H.
   Hofmann, Anna
   Gruber-Blum, Simone
   Petter-Puchner, Alexander H.
   Glaser, Karl S.
TI Delayed closure of open abdomen in septic patients is facilitated by
   combined negative pressure wound therapy and dynamic fascial suture
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   Society-of-American-Gastrointestinal-and-Endoscopic-Surgeons (SAGES)
CY APR 17-20, 2013
CL Baltimore, MD
SP Soc Amer Gastrointestinal & Endoscop Surg
DE Secondary peritonitis; Open abdomen; Negative pressure wound therapy;
   Dynamic fascial suture; Delayed closure
ID ABDOMINAL-WALL DEFECTS; MANAGEMENT; MESH
AB The aim of this prospective controlled trial was the definition of the optimal timepoint for delayed closure after negative pressure wound therapy (NPWT) in the treatment of the open abdomen (OA) in septic patients after abdominal surgery. The delayed closure of the abdominal wall after abdominal NPWT treatment is often problematic due to the lateralization of the fascial edge leading to unfavorably high tensile forces of the adapting sutures in the midline. We present the results of an innovative combination of NPWT with a new fascial-approximation technique using dynamic fascial sutures (DFS) and delayed closure of the abdominal wall.
   Eighty-seven patients subjected to OA therapy following surgery for secondary peritonitis were treated with NPWT and DFS. In all patients, a running suture of elastic vessel loops was used to approximate fascial edges. This procedure was continued for the duration of NPWT until final closure of the abdomen with running suture in 55 patients (63.2 %) and interrupted suture technique in eight patients (9.2 %). An anterior component separation was performed in seven patients.
   Delayed closure was achieved in 68 patients (78.2 %) after 12.6 days [mean (SD) 25.1 (2-204)] days and 4.3 re-operations [mean (SD) 6.0 (1-43)]. Fifteen (17.2 %) superficial and two (2.3 %) deep wound infections occurred. In three (3.4 %) cases, entero-atmospheric fistulas had to be treated. We recorded no technique-specific complications. Four (5.9 %) incisional hernia were detected in a mean follow-up of 40.5 months (16-65). Mortality rate was 55.2 %.
   Using a new technique combining NPWT and DFS in the treatment of the OA, the delayed closure of the fascial edges by running suture can be achieved and the number of re-operations can be kept low. The technique was safe and led to a low incidence of incisional hernias. Extensive abdominal wall reconstruction was seldom required.
C1 [Fortelny, Rene H.; Hofmann, Anna; Gruber-Blum, Simone; Petter-Puchner, Alexander H.; Glaser, Karl S.] Wilhelminenspital Stadt Wien, Dept Gen Visceral & Oncol Surg, A-1171 Vienna, Austria.
   [Hofmann, Anna; Gruber-Blum, Simone; Petter-Puchner, Alexander H.] Ludwig Boltzmann Inst Expt & Clin Traumatol, A-1200 Vienna, Austria.
C3 Wilhelminenspital; Ludwig Boltzmann Institute; Ludwig Boltzmann
   Institute for Experimental & Clinical Traumatology
RP Fortelny, RH (通讯作者)，Wilhelminenspital Stadt Wien, Dept Gen Visceral & Oncol Surg, Montleartstr 37, A-1171 Vienna, Austria.
EM rene.fortelny@wienkav.at
RI /S-5290-2019; Fortelny, René/AAD-5922-2021
CR Albertsmeier M, 2012, LANGENBECK ARCH SURG, V397, P363, DOI 10.1007/s00423-011-0884-6
   Barker DE, 2007, J AM COLL SURGEONS, V204, P784, DOI 10.1016/j.jamcollsurg.2006.12.039
   Bjarnason T, 2011, WORLD J SURG, V35, P917, DOI 10.1007/s00268-010-0937-y
   Björck M, 2009, WORLD J SURG, V33, P1154, DOI 10.1007/s00268-009-9996-3
   Brandl A, 2013, HERNIA
   Canda AE, 2009, HERNIA, V13, P651, DOI 10.1007/s10029-009-0497-y
   Diener MK, 2010, ANN SURG, V251, P843, DOI 10.1097/SLA.0b013e3181d973e4
   Dietz UA, 2012, HERNIA, V16, P451, DOI 10.1007/s10029-012-0919-0
   Israelsson LA, 2012, LANGENBECK ARCH SURG, V397, P1201, DOI 10.1007/s00423-012-1019-4
   Jernigan TW, 2003, ANN SURG, V238, P349, DOI 10.1097/01.sla.0000086544.42647.84
   Kafka-Ritsch R, 2012, WORLD J SURG, V36, P1765, DOI 10.1007/s00268-012-1586-0
   Keramati M, 2008, BURNS, V34, P493, DOI 10.1016/j.burns.2007.06.024
   Koniaris LG, 2001, ARCH SURG-CHICAGO, V136, P1359, DOI 10.1001/archsurg.136.12.1359
   Latifi R, 2012, WORLD J SURG, V36, P516, DOI 10.1007/s00268-011-1306-1
   Millbourn D, 2011, HERNIA, V15, P261, DOI 10.1007/s10029-010-0775-8
   Millbourn D, 2009, ARCH SURG-CHICAGO, V144, P1056, DOI 10.1001/archsurg.2009.189
   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
   Mingoli A, 1999, ITAL J GASTROENTEROL, V31, P449
   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   Pliakos I, 2010, SURGERY, V148, P947, DOI 10.1016/j.surg.2010.01.021
   RAMIREZ OM, 1990, PLAST RECONSTR SURG, V86, P519, DOI 10.1097/00006534-199009000-00023
   Regner JL, 2012, WORLD J SURG, V36, P497, DOI 10.1007/s00268-011-1203-7
   Salman AE, 2012, HERNIA
   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
   Verdam FJ, 2011, WORLD J SURG, V35, P2348, DOI 10.1007/s00268-011-1210-8
   Wild T, 2006, ZBL CHIR, V131, pS111, DOI 10.1055/s-2006-921490
NR 26
TC 51
Z9 56
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD MAR
PY 2014
VL 28
IS 3
BP 735
EP 740
DI 10.1007/s00464-013-3251-6
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA AB7HX
UT WOS:000331961500004
PM 24149855
DA 2026-07-24
ER
PT J
AU Bludau, M
   Hölscher, AH
   Herbold, T
   Leers, JM
   Gutschow, C
   Fuchs, H
   Schröder, W
AF Bludau, M.
   Hoelscher, A. H.
   Herbold, T.
   Leers, J. M.
   Gutschow, C.
   Fuchs, H.
   Schroeder, W.
TI Management of upper intestinal leaks using an endoscopic vacuum-assisted
   closure system (E-VAC)
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Esophageal perforation; Anastomotic leakage; Endoscopic vacuum-assisted
   closure system
ID ESOPHAGEAL-PERFORATION; ANASTOMOTIC LEAKAGE; RESECTION; THERAPY; OPTIONS
AB Esophageal perforations and postoperative leakage of esophagogastrostomy are considered to be life-threatening conditions due to the development of mediastinitis and consecutive sepsis. Vacuum-assisted closure (VAC), a well-established treatment method for superficial infected wounds, is based on a negative pressure applied to the wound via a vacuum-sealed sponge. Endoluminal VAC (E-VAC) therapy is a novel method, and experience with its esophageal application is limited.
   This retrospective study summarizes the experience of a center with a high volume of upper gastrointestinal surgery using E-VAC therapy for patients with leakages of the esophagus. The study investigated 14 patients who had esophageal defects treated with E-VAC. Three patients had a spontaneous defect; two patients had an iatrogenic defect; and nine patients had a postoperative esophageal defect.
   The average duration of application was 12.1 days, and an average of 3.9 E-VAC systems were used. For 6 of the 14 patients, E-VAC therapy was combined with the placement of self-expanding metal stents. Complete restoration of the esophageal defect was achieved in 12 (86 %) of the 14 patients. Two patients died due to prolonged sepsis.
   This report demonstrates that E-VAC therapy adds an additional treatment option for partial esophageal wall defects. The combination of E-VAC treatment and endoscopic stenting is a successful novel procedure for achieving a high closure rate.
C1 [Bludau, M.; Hoelscher, A. H.; Herbold, T.; Leers, J. M.; Gutschow, C.; Fuchs, H.; Schroeder, W.] Univ Cologne, Dept Gen Visceral & Canc Surg, D-50937 Cologne, Germany.
C3 University of Cologne
RP Bludau, M (通讯作者)，Univ Cologne, Dept Gen Visceral & Canc Surg, Kerpener Str 62, D-50937 Cologne, Germany.
EM marc.bludau@uk-koeln.de; wolfgang.schroeder@uni-koeln.de
RI /AAP-2598-2021
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Kuehn F, 2012, J GASTROINTEST SURG, V16, P2145, DOI 10.1007/s11605-012-2014-3
   Leers JM, 2009, SURG ENDOSC, V23, P2258, DOI 10.1007/s00464-008-0302-5
   Loske G, 2011, ENDOSCOPY, V43, P540, DOI 10.1055/s-0030-1256345
   Loske G, 2010, ENDOSCOPY, V42, pE144, DOI 10.1055/s-0029-1244092
   Loske G, 2010, SURG ENDOSC, V24, P2531, DOI 10.1007/s00464-010-0998-x
   Pross M, 2000, GASTROINTEST ENDOSC, V51, P73, DOI 10.1016/S0016-5107(00)70391-9
   Schmidt H, 2001, Kongressbd Dtsch Ges Chir Kongr, V118, P278
   Schorsch T, 2013, SURG ENDOSC, V27, P2040, DOI 10.1007/s00464-012-2707-4
   Vallböhmer D, 2010, DIS ESOPHAGUS, V23, P185, DOI 10.1111/j.1442-2050.2009.01017.x
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Wedemeyer J, 2010, GASTROINTEST ENDOSC, V71, P382, DOI 10.1016/j.gie.2009.07.011
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
   Weidenhagen R, 2010, ANN THORAC SURG, V90, P1674, DOI 10.1016/j.athoracsur.2010.07.007
NR 17
TC 109
Z9 129
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD MAR
PY 2014
VL 28
IS 3
BP 896
EP 901
DI 10.1007/s00464-013-3244-5
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AB7HX
UT WOS:000331961500026
PM 24149851
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Knapp-Hoch, H
   de Matos, R
AF Knapp-Hoch, Heather
   de Matos, Ricardo
TI CLINICAL TECHNIQUE: NEGATIVE PRESSURE WOUND THERAPY-GENERAL PRINCIPLES
   AND USE IN AVIAN SPECIES
SO JOURNAL OF EXOTIC PET MEDICINE
LA English
DT Article
DE avian; negative pressure wound therapy; vacuum-assisted closure; wound
   management
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; DOGS; SKIN; CAT; EXPERIENCE;
   NECROSIS
AB Negative pressure wound therapy (NPWT) is an adjunctive wound management modality that has been shown to augment the treatment of acute and chronic dermal and subdermal wounds in human and veterinary medicine. The proposed effects of NPWT are multifactorial and include improvement of wound perfusion, reduction of interstitial edema and substances inhibitory to wound healing, enhancement of granulation tissue formation, and reduction in bacterial contamination from a wound bed. Together, the proposed benefits of NVVPT can lead to enhanced efficiency of wound healing when this treatment modality is applied to a wound. In this article, the authors provide an overview of the mechanism of action of NPWT. Case selection, system application and management, as well as contraindications to NPWT therapy are presented. Potential uses, practical application, and limitations of use of NPWT in avian species are discussed. Copyright 2014 Elsevier Inc. All rights reserved.
C1 [Knapp-Hoch, Heather; de Matos, Ricardo] Cornell Univ, Coll Vet Med, Dept Clin Sci, Ithaca, NY 14850 USA.
C3 Cornell University
RP de Matos, R (通讯作者)，Cornell Univ, Coll Vet Med, Dept Clin Sci, VMC Box 25, Ithaca, NY 14850 USA.
EM rd95@cornell.edu
CR Adkesson MJ, 2007, JAVMA-J AM VET MED A, V231, P1249, DOI 10.2460/javma.231.8.1249
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   Bovill E, 2008, INT WOUND J, V5, P511, DOI 10.1111/j.1742-481X.2008.00437.x
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   Ritzman Tracey K., 2004, Veterinary Clinics of North America Exotic Animal Practice, V7, P87, DOI 10.1016/j.cvex.2003.08.003
   SPEARMAN R. I. C., 1985, FORM FUNCTION BIRDS, V3, P1
   Wood Benjamin C, 2011, J Surg Orthop Adv, V20, P168
NR 33
TC 3
Z9 7
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1557-5063
EI 1931-6283
J9 J EXOT PET MED
JI J. Exot. Pet Med.
PD JAN
PY 2014
VL 23
IS 1
BP 56
EP 66
DI 10.1053/j.jepm.2013.11.010
PG 11
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA AB7RH
UT WOS:000331987900006
DA 2026-07-24
ER
PT J
AU Vos, RJ
   van Putte, BP
   Sonker, U
   Kloppenburg, GTL
AF Vos, Roemer J.
   van Putte, Bart P.
   Sonker, Uday
   Kloppenburg, Geoffrey T. L.
TI Primary closure using Redon drains for the treatment of post-sternotomy
   mediastinitis
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Mediastinitis; Infection; Redon drainage; Sternotomy
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; POSTOPERATIVE
   MEDIASTINITIS; CONVENTIONAL TREATMENT; RISK-FACTORS; THERAPY;
   DEBRIDEMENT; INFECTIONS; CATHETERS
AB OBJECTIVES: Post-sternotomy mediastinitis is a severe complication of open heart surgery resulting in prolonged hospital stay and increased mortality. Vacuum-assisted closure is commonly used as treatment for post-sternotomy mediastinitis, but has some disadvantages. Primary closure over high vacuum suction Redon drains previously has shown to be an alternative approach with promising results. We report our short-and long-term results of Redon therapy-treated mediastinitis.
   METHODS: We performed a retrospective analysis of 124 patients who underwent primary closure of the sternum over Redon drains as treatment for post-sternotomy mediastinitis in Amphia Hospital (Breda, Netherlands) and St. Antonius Hospital (Nieuwegein, Netherlands). Patient characteristics, preoperative risk factors and procedure-related variables were analysed. Duration of therapy, hospital stay, treatment failure and mortality as well as C-reactive protein and blood leucocyte counts on admission and at various time intervals during hospital stay were determined.
   RESULTS: Mean age of patients was 68.7 +/- 11.0 years. In 77.4%, the primary surgery was coronary artery bypass grafting. Presentation of mediastinitis was 15.2 +/- 9.8 days after surgery. Duration of Redon therapy was 25.9 +/- 18.4 days. Hospital stay was 32.8 +/- 20.7 days. Treatment failure occurred in 8.1% of patients. In-hospital mortality was 8.9%. No risk factors were found for mortality or treatment failure. The median follow-up time was 6.6 years. One-and 5-year survivals were 86 and 70%, respectively.
   CONCLUSIONS: Primary closure using Redon drains is a feasible, simple and efficient treatment modality for post-sternotomy mediastinitis.
C1 [Vos, Roemer J.; Sonker, Uday; Kloppenburg, Geoffrey T. L.] St Antonius Hosp, Dept Cardiothorac Surg, NL-3435 CM Nieuwegein, Netherlands.
   [van Putte, Bart P.] Amphia Hosp, Dept Cardiothorac Surg, Breda, Netherlands.
C3 St. Antonius Hospital Utrecht; Amphia Hospital
RP Vos, RJ (通讯作者)，St Antonius Hosp, Dept Cardiothorac Surg, Koekoekslaan 1, NL-3435 CM Nieuwegein, Netherlands.
EM roemervos@gmail.com
OI Vos, Roemer/0000-0002-2511-988X
CR Atkins BZ, 2011, AM J SURG, V202, P565, DOI 10.1016/j.amjsurg.2011.06.013
   Berg HF, 2000, ANN THORAC SURG, V70, P924, DOI 10.1016/S0003-4975(00)01524-1
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NR 16
TC 7
Z9 14
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JAN
PY 2014
VL 18
IS 1
BP 33
EP 37
DI 10.1093/icvts/ivt385
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AB8II
UT WOS:000332033200010
PM 24071369
DA 2026-07-24
ER
PT J
AU Björck, M
   Wanhainen, A
AF Bjorck, M.
   Wanhainen, A.
TI Management of Abdominal Compartment Syndrome and the Open Abdomen
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE Abdominal aortic aneurysm; Abdominal compartment syndrome; Consensus
   guidelines; Grading of recommendations; Intra-abdominal hypertension;
   Open abdomen; Rupture; Temporary abdominal closure
ID CLINICAL-PRACTICE GUIDELINES; MEDIATED FASCIAL TRACTION; ASSISTED WOUND
   CLOSURE; INTRAABDOMINAL HYPERTENSION; INTERNATIONAL-CONFERENCE;
   ENDOVASCULAR REPAIR; AORTOILIAC SURGERY; DAMAGE CONTROL; SIGMOID COLON;
   PRESSURE
AB Objectives: The management of the abdominal compartment syndrome (ACS) and the open abdomen (OA) are important to improve survival after major vascular surgery, in particular ruptured abdominal aortic aneurysm (RAAA). The aim is to summarize contemporary knowledge in this field.
   Methods: The consensus definitions of the World Society of the Abdominal Compartment Syndrome (WSACS) that were published in 2006 and the clinical practice guidelines published in 2007 were updated in 2013. Structured clinical questions were formulated (modified Delphi method), and the evidence base to answer those questions was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) guidelines.
   Results: Most of the previous definitions were kept untouched, or were slightly modified. Four new definitions were added, including a definition of OA and of lateralization of the abdominal wall, an important clinical problem to approach during prolonged OA treatment. A classification system of the OA was added.
   Seven recommendations were formulated, in summary: Trans-bladder intra-abdominal pressure (IAP) should be monitored in patients at risk. Protocolized monitoring and management are recommended, and decompression laparotomy if ACS. When OA, protocolized efforts to obtain an early abdominal fascial closure, and strategies utilizing negative pressure wound therapy should be used, versus not. In most cases the evidence was graded as weak or very weak. In six of the structured clinical questions, no recommendation could be made.
   Conclusion: This review summarizes changes in definitions and management guidelines of relevance to vascular surgery, and data on the incidence of ACS after open and endovascular aortic surgery. (C) 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Bjorck, M.; Wanhainen, A.] Uppsala Univ, Dept Surg Sci, Vasc Surg Sect, SE-75185 Uppsala, Sweden.
C3 Uppsala University
RP Björck, M (通讯作者)，Uppsala Univ, Dept Surg Sci, SE-75185 Uppsala, Sweden.
EM martin@bjorck.pp.se
RI Bjorck, Martin/A-4104-2008
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NR 40
TC 47
Z9 63
U1 0
U2 13
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD MAR
PY 2014
VL 47
IS 3
BP 279
EP 287
DI 10.1016/j.ejvs.2013.12.014
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA AC1OI
UT WOS:000332265500011
PM 24447530
DA 2026-07-24
ER
PT J
AU Kucharzewski, M
   Mieszczanski, P
   Wilemska-Kucharzewska, K
   Taradaj, J
   Kuropatnicki, A
   Sliwinski, Z
AF Kucharzewski, Marek
   Mieszczanski, Pawel
   Wilemska-Kucharzewska, Katarzyna
   Taradaj, Jakub
   Kuropatnicki, Andrzej
   Sliwinski, Zbigniew
TI The Application of Negative Pressure Wound Therapy in the Treatment of
   Chronic Venous Leg Ulceration: Authors Experience
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB The aim of the study was to use negative pressure wound therapy (NPWT) in patients with chronic venous leg ulceration. The authors present their experience in treatment of 15 patients whose average ulceration surface area was 62.6 cm(2). In 10 patients, the ulcers healed within 6 weeks and in the remaining patients within 20 weeks. Based on the results obtained, the authors imply that NPWT is an effective method in the treatment of chronic venous leg.
C1 [Kucharzewski, Marek] Med Univ Silesia, Dept Descript & Topog Anat, PL-41808 Zabrze, Poland.
   [Kucharzewski, Marek; Wilemska-Kucharzewska, Katarzyna] Specialist Hosp 2, Outpatient Surg Ctr 2, PL-41902 Bytom, Poland.
   [Mieszczanski, Pawel] NZOZ Dist Hosp, Dept Gen Surg, PL-46200 Kluczbork, Poland.
   [Taradaj, Jakub] Acad Phys Educ Katowice, Dept Physiotherapy Basics, PL-40065 Katowice, Poland.
   [Kuropatnicki, Andrzej] Pedag Univ Krakow, Chair Euroamer Hist & Culture, PL-31128 Krakow, Poland.
   [Kuropatnicki, Andrzej] Med Univ Silesia, Dept Foreign Languages, PL-41808 Zabrze, Poland.
   [Sliwinski, Zbigniew] Jan Kochanowski Univ, Fac Hlth Sci, Inst Physiotherapy, PL-25317 Kielce, Poland.
C3 Medical University of Silesia; Akademia Wychowania Fizycznego im.
   Jerzego Kukuczki w Katowicach; University of the National Education
   Commission; Medical University of Silesia; Jan Kochanowski University
RP Kucharzewski, M (通讯作者)，Med Univ Silesia, Dept Descript & Topog Anat, Jordana 19, PL-41808 Zabrze, Poland.
EM kucharzewskimarek@poczta.onet.pl
RI ; Śliwiński, Zbigniew/O-2678-2014; Taradaj, Jakub/T-5411-2018
OI Kucharzewski, Marek/0000-0001-7950-679X; Śliwiński,
   Zbigniew/0000-0001-7402-1793; Taradaj, Jakub/0000-0002-1796-5832;
   Kuropatnicki, Andrzej K/0000-0001-9977-7431
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NR 20
TC 7
Z9 9
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT-UK
JI Biomed Res. Int.
PY 2014
VL 2014
AR 297230
DI 10.1155/2014/297230
PG 5
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA AC1QW
UT WOS:000332272100001
PM 24696847
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU McGarry, TJ
   Joshi, R
   Kawata, H
   Patel, J
   Feld, G
   Birgersdotter-Green, UM
   Pretorius, V
AF McGarry, Thomas J.
   Joshi, Rajeev
   Kawata, Hiro
   Patel, Jigar
   Feld, Gregory
   Birgersdotter-Green, Ulrika M.
   Pretorius, Victor
TI Pocket infections of cardiac implantable electronic devices treated by
   negative pressure wound therapy
SO EUROPACE
LA English
DT Article
DE Cardiac implantable electronic device; Pocket infection; Negative
   pressure wound therapy
ID VACUUM-ASSISTED-CLOSURE; UNITED-STATES; CARDIOVERTER-DEFIBRILLATORS;
   LEAD EXTRACTION; RATES; MANAGEMENT; MORTALITY; FOOT; PACEMAKERS; TRENDS
AB Managing an infection of the pocket of a cardiac implantable electronic device (CIED) is frequently challenging. The wound is often treated with a drain or wet-to-dry dressings that allow healing by secondary intention. Such treatment can prolong the hospital stay and can frequently result in a disfiguring scar. Negative pressure wound therapy (NPWT) has been frequently used to promote the healing of chronic or infected surgical wounds. Here we describe the first series of 28 patients in which NPWT was successfully used to treat CIED pocket infections.
   After removal of the CIED and debridement of the pocket, a negative pressure of 125 mmHg continuously applied to the wound through an occlusive dressing. Negative pressure wound therapy was continued for a median of 5 days (range 215 days) and drained an average of 260 mL sero-sanguineous fluid (range 35970 mL). At the conclusion of NPWT, delayed primary closure of the pocket was performed with 1-0 prolene mattress sutures. The median length of stay after CIED extraction was 11.0 days (range 243 days). Virtually all infected pockets healed without complications and without evidence of recurrent infection over a median follow-up of 49 days (range 10752 days). One patient developed a recurrent infection when NPWT was discontinued prematurely and a new device was implanted at the infected site.
   We conclude that NPWT is a safe and effective means to promote healing of infected pockets with a low incidence of recurrent infection and a satisfactory cosmetic result.
C1 [McGarry, Thomas J.; Joshi, Rajeev; Kawata, Hiro; Patel, Jigar; Feld, Gregory; Birgersdotter-Green, Ulrika M.] Univ Calif San Diego Hlth Syst, Div Cardiol, Cardiac Electrophysiol Program, Sulpizio Family Cardiovasc Ctr, La Jolla, CA USA.
   [Pretorius, Victor] Univ Calif San Diego Hlth Syst, Sulpizio Family Cardiovasc Ctr, Div Cardiothorac Surg, La Jolla, CA USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Birgersdotter-Green, UM (通讯作者)，9444 Med Ctr Dr MC7411, La Jolla, CA 92037 USA.
EM ubgreen@ucsd.edu
RI /AAG-4316-2021
OI pretorius, victor/0000-0001-6360-4002
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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   Webster J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub2
NR 31
TC 9
Z9 14
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1099-5129
EI 1532-2092
J9 EUROPACE
JI Europace
PD MAR
PY 2014
VL 16
IS 3
BP 372
EP 377
DI 10.1093/europace/eut305
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AC2LK
UT WOS:000332332400015
PM 24127355
OA Bronze
DA 2026-07-24
ER
PT J
AU Shi, YD
   Qi, FZ
   Zhang, Y
AF Shi, Yue-Dong
   Qi, Fa-Zhi
   Zhang, Yong
TI Treatment of sternal wound infections after open-heart surgery
SO ASIAN JOURNAL OF SURGERY
LA English
DT Article
DE infection; muscle flap; sterpotomy
ID TRANSVERSE PLATE FIXATION; RECONSTRUCTION; COMPLICATIONS; MANAGEMENT;
   RISK; FLAP
AB Objective: The aim of this study was to investigate the proper treatment of infected median sternotomy wounds.
   Methods: A retrospective study was conducted to investigate the proper treatment of infected median sternotomy wounds on patients with sternal wound infections from January 2007 to July 2009. The characteristics of the sternal infections and the treatment outcomes were analysed.
   Results: Ninety-seven patients with sternal wound infections were treated. A total of 32 patients acquired the infection within one month after open-heart surgery, 10 patients got the infection one to two months after the surgery, and 1 patient died two days after debridement. There were 54 patients who acquired the infection beyond two months post-surgery, while 1 patient died on the day before the operation. One patient received four cycles of wound debridement, 18 patients received two cycles and 78 patients only received one cycle. A total of 14 patients received a vacuum-assisted closure treatment. There were 73 patients who had surgery for repair of muscle flaps, 1 patient for breast tissue flap, 63 patients for pectoralis major muscle flap, and 9 patients with rectus abdominis muscle flap. There were 12 patients who received a transverse plate fixation of the sternum with titanium plating.
   Conclusion: A positive prognosis can be obtained by the algorithm treatment based on the onset and depth of the sternal infection. Copyright (c) 2013, Asian Surgical Association. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [Shi, Yue-Dong; Qi, Fa-Zhi; Zhang, Yong] Fudan Univ, Zhongshan Hosp, Dept Plast & Reconstruct Surg, Shanghai 200032, Peoples R China.
C3 Fudan University
RP Qi, FZ (通讯作者)，Fudan Univ, Zhongshan Hosp, Dept Plast & Reconstruct Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
EM dsyzcn@163.com
CR Birkmeyer NJO, 1998, CIRCULATION, V97, P1689, DOI 10.1161/01.CIR.97.17.1689
   Cabbabe EB, 2009, PLAST RECONSTR SURG, V123, P1490, DOI 10.1097/PRS.0b013e3181a205f9
   Cicilioni OJ, 2005, PLAST RECONSTR SURG, V115, P1297, DOI 10.1097/01.PRS.0000156918.15595.85
   Cohen DJ, 2002, ANN THORAC SURG, V73, P563
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   Greig AVH, 2007, J PLAST RECONSTR AES, V60, P372, DOI 10.1016/j.bjps.2006.10.005
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   SHUMACKER HB, 1963, ARCH SURG-CHICAGO, V86, P384
NR 19
TC 15
Z9 19
U1 1
U2 3
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD JAN
PY 2014
VL 37
IS 1
BP 24
EP 29
DI 10.1016/j.asjsur.2013.07.006
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AC2SH
UT WOS:000332353800005
PM 23972506
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hisata, Y
   Hashizume, K
   Tanigawa, K
   Miura, T
   Odate, T
   Tasaki, Y
   Eishi, K
AF Hisata, Yoichi
   Hashizume, Koji
   Tanigawa, Kazuyoshi
   Miura, Takashi
   Odate, Tomohiro
   Tasaki, Yuichi
   Eishi, Kiyoyuki
TI Vacuum-assisted closure therapy for salvaging a methicillin-resistant
   Staphylococcus aureus-infected prosthetic graft
SO ASIAN JOURNAL OF SURGERY
LA English
DT Article
DE infected prosthetic graft; methicillin-resistant Staphylococcus aureus;
   wound-closure techniques
ID PRESSURE WOUND THERAPY; MUSCLE FLAP COVERAGE; GROIN; MANAGEMENT;
   PROLIFERATION; PRESERVATION; EXPERIENCE
AB Infection of a vascular prosthesis after a bypass surgery is relatively rare. However, once developed, serious complications can occur, such as bleeding, sepsis, and organ ischemia, occasionally resulting in leg amputation or even death in some cases. The treatment of a vascular prosthesis infection involves the necessary removal of the infected graft; subsequently, an extra-anatomical bypass surgery is often considered. We herein report a case in which postoperative methicillin-resistant Staphylococcus aureus infection caused dehiscence of the femoral vessels and exposure of the graft vessel and anastomosed area. The infected tissue was surgically removed (debridement), and the patient's condition was successfully treated by the application of a nonadherent dressing and vacuum-assisted closure therapy combined with the bridging technique. Copyright (C) d2013, Asian Surgical Association. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [Hisata, Yoichi; Hashizume, Koji; Tanigawa, Kazuyoshi; Miura, Takashi; Odate, Tomohiro; Tasaki, Yuichi; Eishi, Kiyoyuki] Nagasaki Univ Hosp, Div Cardiovasc Surg, Nagasaki 8528108, Japan.
C3 Nagasaki University
RP Hisata, Y (通讯作者)，Nagasaki Univ Hosp, Div Cardiovasc Surg, 1-7-1 Sakamoto, Nagasaki 8528108, Japan.
EM hisata.y@gmail.com
CR Banwell PE, 2002, BRIT J PLAST SURG, V55, P264, DOI 10.1054/bjps.2001.3819
   CALLIGARO KD, 1994, ANN SURG, V220, P461, DOI 10.1097/00000658-199410000-00005
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   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
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NR 16
TC 1
Z9 3
U1 0
U2 0
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD JAN
PY 2014
VL 37
IS 1
BP 46
EP 48
DI 10.1016/j.asjsur.2013.07.001
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AC2SH
UT WOS:000332353800008
PM 23978424
OA Green Submitted
DA 2026-07-24
ER
PT J
AU de Abreu, IRLB
   Pontes, EPO
   Tamagno, MFL
   Sardenberg, RA
   Younes, RN
   Abrao, FC
AF de Abreu, Igor Renato L. B.
   Pontes, Edgard P. O.
   Tamagno, Mauro F. L.
   Sardenberg, Rodrigo Afonso
   Younes, Riad Naim
   Abrao, Fernando Conrado
TI Treatment of thoracic wounds with adapted vacuum therapy
SO ASIAN JOURNAL OF SURGERY
LA English
DT Article
DE infections; thoracic wounds; vacuum therapy
ID ASSISTED CLOSURE; EMPYEMA
AB This is a report of seven cases of infected thoracic wounds treated with an adapted low-cost vacuum therapy in the Thoracic Surgery Unit of Santa Marcelina Hospital. The vacuum system used was designed and adapted to our hospital due to financial limitations on the acquisition of commercial kits. The vacuum-assisted closure kit used in this study consisted of chlorhexidine sponges (which are usually used for antisepsis of the surgical team), a 16F naso-gastric tube, and two sterile adhesive films (OPSITE) for surgical field reinforcement. The mean duration of vacuum therapy was 13.4 days (range, 10-20 days), with an average of three dressing changes (range, 1-5). After treatment with vacuum-assisted closure, three wounds (3/7) were closed with simple primary sutures, one of the lesions (1/7) was closed by muscle flap rotation, and three wounds (3/7) healed by second intention. This adapted vacuum therapy was safe and easy to apply in our institution, including its use in patients with thoracostomies. Copyright (C) 2013, Asian Surgical Association. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [de Abreu, Igor Renato L. B.; Abrao, Fernando Conrado] Hosp Santa Marcelina, Oncol Ctr Hosp Sao Jose, Dept Thorac Surg, Sao Paulo, Brazil.
   [Pontes, Edgard P. O.; Tamagno, Mauro F. L.] Hosp Santa Marcelina, Dept Thorac Surg, Sao Paulo, Brazil.
   [Sardenberg, Rodrigo Afonso] Hosp Sao Jose, Ctr Oncol, Sao Paulo, Brazil.
   [Younes, Riad Naim] Univ Sao Paulo, Dept Surg, Hosp Sao Jose, Ctr Oncol, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Abrao, FC (通讯作者)，Rua Souza Ramos 144,Apto 11, BR-04120080 Sao Paulo, Brazil.
EM fernandocabrao@uol.com.br
OI Abreu, Igor/0000-0003-2071-1427
CR MILLER JI, 1984, ANN THORAC SURG, V38, P227, DOI 10.1016/S0003-4975(10)62243-6
   Molnar TF, 2007, EUR J CARDIO-THORAC, V32, P422, DOI 10.1016/j.ejcts.2007.05.028
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   O'Connor J, 2005, ANN THORAC SURG, V79, P1196, DOI 10.1016/j.athoracsur.2004.09.041
   Palmen M, 2009, ANN THORAC SURG, V88, P1131, DOI 10.1016/j.athoracsur.2009.06.030
   Segers P, 2006, THORAC CARDIOV SURG, V54, P289, DOI 10.1055/s-2006-924003
   Widmer MK, 2000, EUR J CARDIO-THORAC, V18, P435, DOI 10.1016/S1010-7940(00)00538-8
NR 7
TC 2
Z9 2
U1 0
U2 3
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD JAN
PY 2014
VL 37
IS 1
BP 49
EP 52
DI 10.1016/j.asjsur.2013.07.015
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AC2SH
UT WOS:000332353800009
PM 24026077
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Liu, Y
   Zhou, Q
   Wang, YC
   Liu, ZC
   Dong, ML
   Wang, YJ
   Li, X
   Hu, DH
AF Liu, Yang
   Zhou, Qin
   Wang, Yunchuan
   Liu, Zhengcai
   Dong, Maolong
   Wang, Yaojun
   Li, Xiao
   Hu, Dahai
TI Negative Pressure Wound Therapy Decreases Mortality in a Murine Model of
   Burn-Wound Sepsis Involving Pseudomonas aeruginosa Infection
SO PLOS ONE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; INJURY;
   COLONIZATION; PERSISTENCE; VIRULENCE; PATIENT; DEVICE; PAO1; UNIT
AB Background: The colonization of burn wounds by Pseudomonas aeruginosa can lead to septic shock, organ injuries, and high mortality rates. We hypothesized that negative pressure wound therapy (NPWT) would decrease invasion and proliferation of P. aeruginosa within the burn wound and reduce mortality.
   Methods: Thermal injuries were induced in anesthetized mice, and P. aeruginosa was applied to the wound surface for 24 h. After removing the burn eschar and debridement, the animals were subjected to either NPWT or wet-to-dry (WTD) treatment protocols. The bacterial loads on the wound surface were assessed during 7 d of treatment, as were the concentrations of inflammatory cytokines in the peripheral blood samples. Survival was monitored daily for 14 d after burn induction. Finally, samples of wounded skin, lung, liver, and kidney were collected and subjected to histopathological examination.
   Results: Applying P. aeruginosa to the burn wound surface led to sepsis. During early stages of treatment, NPWT reduced the mortality of the septic animals and levels of P. aeruginosa within the burn wound compared with WTD-treated animals. Circulating levels of cytokines and cytoarchitectural abnormalities were also significantly reduced via NPWT.
   Conclusions: Our data indicate that NPWT inhibits the invasion and proliferation of P. aeruginosa in burn-wounded tissue and decreases early mortality in a murine model of burn-wound sepsis. These therapeutic benefits likely result from the ability of NPWT to decrease bacterial proliferation on the wound surface, reduce cytokine serum concentrations, and prevent damage to internal organs.
C1 [Liu, Yang; Zhou, Qin; Wang, Yunchuan; Dong, Maolong; Wang, Yaojun; Hu, Dahai] Fourth Mil Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, Xian 710032, Shaanxi, Peoples R China.
   [Liu, Zhengcai; Li, Xiao] Fourth Mil Med Univ, Xijing Hosp, Dept Hepatobiliary Surg, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Hu, DH (通讯作者)，Fourth Mil Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, Xian 710032, Shaanxi, Peoples R China.
EM hudahaifmmu@163.com
RI ; Wang, Yunchuan/LWK-1681-2024
OI Liu, Zhengcai/0000-0001-5046-440X; Hu, Dahai/0000-0001-5543-092X
FU Academic Support Program Funds of Xijing Hospital, the Fourth Military
   Medical University
FX The study was supported by grants from the Academic Support Program
   Funds of Xijing Hospital, the Fourth Military Medical University. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 32
TC 68
Z9 84
U1 1
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 28
PY 2014
VL 9
IS 2
AR e90494
DI 10.1371/journal.pone.0090494
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AC3DW
UT WOS:000332396200213
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Swanson, EA
   Freeman, LJ
   Seleem, MN
   Snyder, PW
AF Swanson, Elizabeth A.
   Freeman, Lynetta J.
   Seleem, Mohamed N.
   Snyder, Paul W.
TI Biofilm-infected wounds in a dog
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID NEGATIVE-PRESSURE; BACTERIAL; DIVERSITY; DEBRIDEMENT; DIAGNOSTICS;
   THERAPY; CARE
AB Case Description-A 4-year-old spayed female Mastiff was evaluated for treatment of chronic nonhealing pressure wounds over both elbow regions resulting from attempts at hypertrophic callus excision.
   Clinical Findings-The wound bed granulation tissue was mottled red and yellow with hyperemic, rolled epithelial edges. The right wound communicated with a large fluid pocket along the thoracic wall. The dog had an inflammatory leukogram with a left shift.
   Treatment and Outcome-The wounds were debrided, and tissue specimens were collected for histologic evaluation, microbial culture, and bacterial identification by means of molecular diagnostic techniques. The left wound was closed immediately. Calcium alginate rope with silver was packed into the right wound. Vacuum-assisted closure was applied for 6 days. Debridement was repeated, and a thoracodorsal axial pattern flap was used to cover the wound. Systemic treatment with antimicrobials was initiated, and pressure over the elbow regions was relieved. Bacterial biofilms were identified histologically in tissue specimens from both wounds. Staphylococcus intermedius, Staphylococcus epidermidis, and Streptococcus canis were cultured and identified by 16S rRNA fragment sequencing. Pyrosequencing identified multiple bacterial species and no fungal organisms. Both wounds healed successfully.
   Clinical Relevance-Biofilms are implicated in infected orthopedic implants in veterinary patients; however, this is the first report of a bacterial biofilm in chronic wounds in a dog. In human wound care, extensive debridement is performed to disrupt the biofilm; a multimodal treatment approach is recommended to delay reformation and help clear the infection. In this case, biofilm reformation was prevented by systemic treatment with antimicrobials, by reducing local pressure on the wounds, and by wound closure.
C1 [Swanson, Elizabeth A.; Freeman, Lynetta J.] Purdue Univ, Coll Vet Med, Dept Vet Clin Sci, W Lafayette, IN 47907 USA.
   [Seleem, Mohamed N.; Snyder, Paul W.] Purdue Univ, Coll Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA.
C3 Purdue University System; Purdue University; Purdue University System;
   Purdue University
RP Swanson, EA (通讯作者)，Mississippi State Univ, Coll Vet Med, Dept Clin Sci, Mississippi State, MS 39762 USA.
EM eswanson@cvm.msstate.edu
RI Seleem, Mohamed/H-2774-2018
OI Seleem, Mohamed/0000-0003-0939-0458; Freeman,
   Lynetta/0000-0002-4077-1497
CR [Anonymous], 2012, EPLASTY
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   Wolcott RD, 2010, J WOUND CARE, V19, P320, DOI 10.12968/jowc.2010.19.8.77709
   Wolcott RD, 2010, J WOUND CARE, V19, P272
   Wolcott R, 2011, PLAST RECONSTR SURG, V127, p28S, DOI 10.1097/PRS.0b013e3181fca244
   Wolcott RD, 2008, JAMA-J AM MED ASSOC, V299, P2682, DOI 10.1001/jama.299.22.2682
   Wolcott RD, 2010, ADV WOUND CARE-SER, V1, P311, DOI 10.1089/awc.2009.0104
NR 31
TC 25
Z9 30
U1 0
U2 34
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
EI 1943-569X
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD MAR 15
PY 2014
VL 244
IS 6
BP 699
EP 707
DI 10.2460/javma.244.6.699
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA AC4LQ
UT WOS:000332493200009
PM 24568112
DA 2026-07-24
ER
PT J
AU Asher, SA
   White, HN
   Illing, EA
   Carroll, WR
   Magnuson, JS
   Rosenthal, EL
AF Asher, Scott A.
   White, Hilliary N.
   Illing, Elisa A.
   Carroll, William R.
   Magnuson, J. Scott
   Rosenthal, Eben L.
TI Intraluminal Negative Pressure Wound Therapy for Optimizing Pharyngeal
   Reconstruction
SO JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
LA English
DT Article
ID SALVAGE TOTAL LARYNGECTOMY; ORGAN PRESERVATION THERAPY; ASSISTED CLOSURE
   DEVICE; PHARYNGOCUTANEOUS-FISTULA; ANASTOMOTIC LEAKAGE; VACUUM THERAPY;
   SOFT-TISSUE; NECK WOUNDS; MANAGEMENT; COMPLICATIONS
AB IMPORTANCE Pharyngocutaneous fistula formation after pharyngeal reconstruction is one of the most common and challenging problems to manage. Despite many advances in management, the published success rates indicate a role for any adjuvant therapy that could potentially decrease this complication.
   OBJECTIVE To describe the use of intraluminal negative pressure dressings (NPDs) in pharyngeal reconstruction.
   DESIGN, SETTING, AND PARTICIPANTS Retrospective case series at a tertiary care academic hospital. Twelve laryngectomy patients underwent pharyngeal reconstruction augmented by placement of an intrapharyngeal NPD in combination with the introduction of vascularized tissue from August 2011 to May 2012. All patients had potential risk factors for compromised wound healing defined as previous radiation therapy, hypothyroidism, diabetes mellitus, compromised nutrition, or established pharyngocutaneous fistula.
   INTERVENTIONS An NPD was placed in an intraluminal position spanning the length of the pharyngeal defect as part of the reconstructive procedure. The negative pressure sponge was attached to a standard nasogastric tube to which negative pressure was applied. External closure of the pharynx was then achieved with regional or free tissue transfer.
   MAIN OUTCOMES AND MEASURES Pharyngeal closure rates, timing until return to oral diet, identification of wound healing risk factors, and adverse events related to use of the device.
   RESULTS Eleven of 12 patients (92%) achieved pharyngeal closure with reconstruction using negative pressure wound therapy. All patients had at least 1 potential risk factor for compromised wound healing, with 11 of 12 (92%) having 2 or more. Seven patients had an established pharyngocutaneous fistula, and 5 patients underwent primary reconstruction after laryngopharyngectomy. In 6 of these 7 patients undergoing fistula repair, pharyngeal closure was achieved, and they resumed an oral diet at 1 week postoperatively. The other had successful leak repair initially, but 1 week later developed a separate area of wound breakdown and a second fistula. All 5 patients in whom an intraluminal NPD was placed at the time of initial vacularized tissue reconstruction were able to resume an oral diet by 3 weeks postoperatively, with 3 of them eating by mouth at 1 week postoperatively. No serious adverse events could be attributed to the use of intraluminal NPDs.
   CONCLUSIONS AND RELEVANCE Intraluminal negative pressure wound therapy is feasible and safe. Future research should be conducted to determine its potential in optimizing pharyngeal reconstruction in high-risk patients.
C1 [Asher, Scott A.; White, Hilliary N.; Illing, Elisa A.; Carroll, William R.; Magnuson, J. Scott; Rosenthal, Eben L.] Univ Alabama Birmingham, Div Otolaryngol Head & Neck Surg, Dept Surg, Sch Med, Birmingham, AL USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Rosenthal, EL (通讯作者)，Div Otolaryngol Head & Neck Surg, BDB Ste 563,1808 7th Ave South, Birmingham, AL 35233 USA.
EM oto@uab.edu
RI Rosenthal, Eben/KLC-3513-2024; Magnuson, Jason/ABX-9283-2022
OI Rosenthal, Eben/0000-0003-0294-5203; 
CR Andrades P, 2008, LARYNGOSCOPE, V118, P1157, DOI 10.1097/MLG.0b013e31816f695a
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   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
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NR 42
TC 23
Z9 30
U1 0
U2 4
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6181
EI 2168-619X
J9 JAMA OTOLARYNGOL
JI JAMA Otolaryngol-Head Neck Surg.
PD FEB
PY 2014
VL 140
IS 2
BP 143
EP 149
DI 10.1001/jamaoto.2013.6143
PG 7
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA AC8FB
UT WOS:000332767800010
PM 24370595
DA 2026-07-24
ER
PT J
AU Wagstaff, MJD
   Driver, S
   Coghlan, P
   Greenwood, JE
AF Wagstaff, Marcus James Dermot
   Driver, Sara
   Coghlan, Patrick
   Greenwood, John Edward
TI A randomized, controlled trial of negative pressure wound therapy of
   pressure ulcers via a novel polyurethane foam
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DERMAL MATRIX; POLYMER; SKIN
AB The objectives of the study were (1) to look for any local, clinically apparent response, within and around a debrided wound, to a novel biocompatible polyurethane foam during repeated, short-term implantation, and (2) to assess the material's efficacy as a negative pressure wound therapy (NPWT) interface compared with a widely used, commercially available foam. Twenty pressure ulcers in 18 patients underwent surgical debridement, then randomization to receive novel treatment or control foam as the wound interface for NPWT. Dressing changes every 2-3 days allowed qualitative wound assessment and quantitative measurement to compare outcomes. No adverse reaction was observed in any patient receiving the new foam. The new novel foam performed as a NPWT interface as effectively as the control standard foam. In deep wounds, the new foam was easier to remove, fragmented less, and showed less retention than the control foam. No marginal in-growth occurred, making removal less traumatic and reducing bleeding from cavity wall granulations. The results support previous large animal studies, and independent ISO10993 testing, that the new foam is safe and biocompatible. Its efficacy as an NPWT interface, nontraumatic removal with low fragmentation and retention rate, favors the new material, especially in deep cavity wounds.
C1 [Wagstaff, Marcus James Dermot] Royal Adelaide Hosp, Dept Plast & Reconstruct Surg, Adelaide, SA 5000, Australia.
   [Coghlan, Patrick; Greenwood, John Edward] Royal Adelaide Hosp, Adult Burn Ctr, Adelaide, SA 5000, Australia.
   [Driver, Sara] Royal Dist Nursing Serv, Adelaide, SA, Australia.
C3 Royal Adelaide Hospital; Royal Adelaide Hospital
RP Greenwood, JE (通讯作者)，Royal Adelaide Hosp, Adult Burn Ctr, N Terrace, Adelaide, SA 5000, Australia.
EM john.greenwood@health.sa.gov.au
OI Wagstaff, Marcus/0000-0003-3160-3720
FU PolyNovo Biomaterials Pty Ltd, Port Melbourne, Victoria, Australia
FX Funding for this study was provided by PolyNovo Biomaterials Pty Ltd,
   Port Melbourne, Victoria, Australia, who provided the treatment
   materials (NovoPore) and paid the RDNS to backfill the position of the
   study nurse. By virtue of the gratis supply of pumps, dressings and
   control foam, Kinetic Concepts Incorporated, San Antonio, Texas,
   additionally supported the trial.
CR [Anonymous], 2009, FDA PREL PUBL HLTH N
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Dearman BL, 2013, J BURN CARE RES, V34, P151, DOI 10.1097/BCR.0b013e31828089f9
   FDA Safety Communication, 2011, UPDATE SER COMPL ASS
   Greenwood JE, 2010, WOUND PRACT RES, V18, P14
   Greenwood JE, 2010, WOUND PRACT RES, V18, P24
   Greenwood JE, 2012, J BURN CARE RES, V33, P7, DOI 10.1097/BCR.0b013e3182372be9
   Greenwood JE, 2012, J BURN CARE RES, V33, P163, DOI 10.1097/BCR.0b013e318233fac1
   Li A, 2009, J BURN CARE RES, V30, P717, DOI 10.1097/BCR.0b013e3181abffca
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
NR 10
TC 32
Z9 41
U1 0
U2 26
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR
PY 2014
VL 22
IS 2
BP 205
EP 211
DI 10.1111/wrr.12146
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA AC9DV
UT WOS:000332835400188
PM 24635170
DA 2026-07-24
ER
PT J
AU Kakagia, D
   Karadimas, EJ
   Drosos, G
   Ververidis, A
   Trypsiannis, G
   Verettas, D
AF Kakagia, D.
   Karadimas, E. J.
   Drosos, G.
   Ververidis, A.
   Trypsiannis, G.
   Verettas, D.
TI Wound closure of leg fasciotomy: Comparison of vacuum-assisted closure
   versus shoelace technique. A randomised study
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Fasciotomy; Wound; Leg injury; Vacuum-assisted closure; Shoelace
   technique
ID DELAYED PRIMARY CLOSURE; ACUTE COMPARTMENT SYNDROME; VESSEL LOOP
   SHOELACE; DEVICE; TRAUMA
AB Background: Fasciotomies, though essential for the prevention and management of compartment syndromes, may increase morbidity and prolong hospitalisation. Two widely applied methods of delayed primary closure are compared in leg fasciotomy wounds.
   Patients and methods: Two groups, each of 25 patients with leg fasciotomies due to fractures and soft tissue injuries, who were randomly assigned to be treated either by vacuum assisted closure (VAC (R), n = 42 wounds, group V) or by the shoelace technique (n = 40 wounds, group S), were evaluated in this study. Wound length, time to definite closure, complications, need for additional interventions and daily treatment costs were data collected and statistically assessed.
   Results: Wound closure time was significantly higher in group V compared to group S (p = 0.001; 95% CI of the difference, 1.8-6.3 days).
   Five group V patients required split thickness skin grafts. In six group S patients, the vessel loops had to be replaced.
   The mean daily cost of negative pressure therapy alone was 135 euro (range 117-144 euro), whilst the mean daily cost of treatment for the shoelace technique was 14 euro ranging from 8 to 18 euro (p = <0.001).
   Conclusions: Both VAC (R) and the shoelace technique are safe, reliable and effective methods for closure of leg fasciotomy wounds. VAC (R) requires longer time to definite wound closure and is far more expensive than the shoelace technique, especially when additional skin grafting is required. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Kakagia, D.] Democritus Univ Thrace Hosp, Dept Plast & Reconstruct Surg, Alexandroupolis, Greece.
   [Karadimas, E. J.; Drosos, G.; Ververidis, A.; Verettas, D.] Democritus Univ Thrace Hosp, Dept Orthoped, Alexandroupolis, Greece.
   [Karadimas, E. J.] Hellen Red Cross Hosp, Dept Orthoped, Athens, Greece.
   [Trypsiannis, G.] Democritus Univ Thrace, Dept Med Stat, Alexandroupolis, Greece.
C3 Democritus University of Thrace; Democritus University Thrace Hospital;
   Democritus University of Thrace; Democritus University Thrace Hospital;
   Democritus University of Thrace
RP Kakagia, D (通讯作者)，7 P Kirillou Str, Alexandroupolis 68100, Greece.
EM despoinakakagia@yahoo.com
RI Kakagia, Despoina/AAP-1202-2021
OI Kakagia, Despoina/0000-0003-2107-6170
CR Almekinders L C, 1991, Orthop Rev, V20, P84
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   MUBARAK SJ, 1983, SURG CLIN N AM, V63, P539
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NR 28
TC 57
Z9 77
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD MAY
PY 2014
VL 45
IS 5
BP 890
EP 893
DI 10.1016/j.injury.2012.02.002
PG 4
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA AD2AS
UT WOS:000333035500015
PM 22377275
DA 2026-07-24
ER
PT J
AU Sashida, Y
AF Sashida, Yasunori
TI New chest tube management maintained with negative pressure therapy
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Wound healing; negative pressure therapy; chest tube management;
   pressure sore; empyema; lung abscess
ID VACUUM-ASSISTED CLOSURE; FOUNDATION; DRAINAGE
AB Management of a chest tube, especially when lasting for a long period, becomes difficult. The orifice of thoracostomy where a tube is inserted is maintained sterile usually with water-tight sutures. The longer and tighter the sutures are placed, the more severely skin becomes sore by pressure. Recently not only pressure sores but also other various open wounds were successfully treated by negative pressure therapy. This study presents two cases of intrathoracic abscess which were successfully treated by chest tube maintained with negative pressure therapy. One case was a bed-ridden cerebral palsy patient with empyema thoracis and the other was a premature baby with lung abscess. Both needed a chest tube longer than a month. Negative pressure was applied not only in the abscess cavity but also in the wound of tube insertion, thus simultaneously draining the abscess and accelerating the wound healing of the tube insertion. It was gradually elevated from 20 to 50 H2O (14.7 to 36.7 mmHg), which is below the level of the physiologic forced inspiration, with a 10 cm H2O (7.4 mmHg) increase every other day. Both abscesses disappeared without a complication.
C1 Okinawa Prefectural Chubu Hosp, Div Plast Surg, Uruma City, Okinawa 9042293, Japan.
RP Sashida, Y (通讯作者)，Okinawa Prefectural Chubu Hosp, Div Plast Surg, Kyoku 281, Uruma City, Okinawa 9042293, Japan.
EM sashida@cosmos.ne.jp
CR Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   Manzanet G, 2005, CHEST, V127, P2211, DOI 10.1378/chest.127.6.2211
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Munnell ER, 1997, ANN THORAC SURG, V63, P1497, DOI 10.1016/S0003-4975(97)00082-9
   Palmen M, 2009, ANN THORAC SURG, V88, P1131, DOI 10.1016/j.athoracsur.2009.06.030
   Wongworawat MD, 2003, CLIN ORTHOP RELAT R, P45, DOI 10.1097/01.blo.0000084400.53464.02
NR 8
TC 0
Z9 0
U1 0
U2 8
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD APR
PY 2014
VL 48
IS 2
BP 155
EP 157
DI 10.3109/2000656X.2012.762005
PG 3
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA AD2BM
UT WOS:000333037900012
PM 23829503
OA gold
DA 2026-07-24
ER
PT J
AU Bertelsen, CA
   Fabricius, R
   Kleif, J
   Kristensen, B
   Gögenur, I
AF Bertelsen, Claus Anders
   Fabricius, Rasmus
   Kleif, Jakob
   Kristensen, Bent
   Gogenur, Ismail
TI Outcome of Negative-Pressure Wound Therapy for Open Abdomen Treatment
   After Nontraumatic Lower Gastrointestinal Surgery: Analysis of Factors
   Affecting Delayed Fascial Closure in 101 Patients
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; DAMAGE CONTROL;
   INTESTINAL WALL; MANAGEMENT; MESH; LAPAROSTOMY; TRACTION
AB Few studies have focused on the risk factors for failure to achieve fascial closure after use of negative-pressure wound therapy (NPWT) in an open abdomen (OA). We aimed at analyzing possible risk factors for failure of fascial closure and the risk of fistulas after nontrauma lower gastrointestinal (GI) tract surgery treated with OA.
   This retrospective study included 101 nontrauma patients treated with OA from 2007 to 2011. Multivariate analyses of risk factors were performed.
   Indications for OA were diffuse peritonitis (n = 47), need for second look (n = 26), failure to achieve fascial closure (e.g., bowel edema) at primary laparotomy (n = 24), and fascial necrosis (n = 4). Of the 101 patients, 61 (60 %) were alive at discharge, with one death possibly related to OA (fistula from an iatrogenic perforation). Delayed fascial closure was obtained in 40 (66 %) of the surviving patients, with 80 % when the indications for OA was need for second look and 72 % in cases of diffuse peritonitis. Compared with need for second look [hazard ratio (HR = 1), 95 % CI], proportional HR for failure of delayed fascial closure were peritonitis 1.96 (1.10-3.49) and failure to achieve fascial closure at primary laparotomy 4.70 (2.17-10.2). In the presence of a stoma the HR was 2.02 (1.13-3.63).
   OA using NPWT seems to be a safe procedure, with few procedure-related complications. Failure of fascial closure is related to the indication of OA and the presence of a stoma. Prospective multicenter studies are needed to establish which patients with lower GI surgery benefit from OA.
C1 [Bertelsen, Claus Anders; Fabricius, Rasmus; Kleif, Jakob; Gogenur, Ismail] Univ Copenhagen, Hillerod Univ Hosp, Dept Surg, DK-3400 Hillerod, Denmark.
   [Kristensen, Bent] Univ Copenhagen, Hillerod Univ Hosp, Dept Clin Physiol & Nucl Med, DK-3400 Hillerod, Denmark.
   [Gogenur, Ismail] Univ Copenhagen, Herlev Univ Hosp, Dept Surg, DK-2730 Herlev, Denmark.
C3 University of Copenhagen; University of Copenhagen; University of
   Copenhagen; Herlev & Gentofte Hospital
RP Bertelsen, CA (通讯作者)，Univ Copenhagen, Hillerod Univ Hosp, Dept Surg, Dyrehavevej 29, DK-3400 Hillerod, Denmark.
EM cabertelsen@gmail.com
RI ; Bertelsen, Claus Anders/AAZ-8209-2020
OI Gögenur, Ismail/0000-0002-3753-268X; Kleif, Jakob/0000-0002-9330-0410;
   Bertelsen, Claus Anders/0000-0001-6337-8447
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Adkins AL, 2004, AM SURGEON, V70, P137
   Amin AI, 2009, WORLD J GASTROENTERO, V15, P3394, DOI 10.3748/wjg.15.3394
   Carlson GL, 2013, ANN SURG, V257, P1154, DOI 10.1097/SLA.0b013e31828b8bc8
   Caro A, 2011, INT WOUND J, V8, P274, DOI 10.1111/j.1742-481X.2011.00782.x
   Fieger AJ, 2011, ZBL CHIR, V136, P56, DOI 10.1055/s-0030-1247376
   Goussous N, 2014, INJURY, V45, P151, DOI 10.1016/j.injury.2013.01.039
   Goussous N, 2012, SURGERY, V152, P777, DOI 10.1016/j.surg.2012.07.015
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   Hoyrup S, 2012, DAN MED J, V59
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NR 34
TC 25
Z9 29
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD APR
PY 2014
VL 38
IS 4
BP 774
EP 781
DI 10.1007/s00268-013-2360-7
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AD3ND
UT WOS:000333151900004
PM 24337240
DA 2026-07-24
ER
PT J
AU Chen, YE
   Gerstle, T
   Verma, K
   Treiser, MD
   Kimball, AB
   Orgill, DP
AF Chen, Y. Erin
   Gerstle, Theodore
   Verma, Kapil
   Treiser, Matthew D.
   Kimball, Alexandra B.
   Orgill, Dennis P.
TI Management of Hidradenitis Suppurativa Wounds with an Internal Vacuum-
   Assisted Closure Device
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID SUBATMOSPHERIC PRESSURE; DOUBLE-BLIND; THERAPY; EXCISION; GRANULATION;
   BRIDGE
AB Background: Hidradenitis suppurativa is a chronic, debilitating disease that is difficult to treat. Once medical management fails, wide local excision offers the best chance for cure. However, the resultant wound often proves too large or contaminated for immediate closure.
   Methods: The authors performed a retrospective chart review of hidradenitis cases managed surgically between 2005 and 2010. Data collected included patient characteristics, management method, and outcomes. Approximately half of the patients received internal vacuum-assisted closure therapy using the vacuum-assisted closure system and delayed closure and half of the patients received immediate primary closure at the time of their excision. Delayed closure consisted of closing the majority of the wound in a linear fashion following internal vacuum-assisted closure while accepting healing by means of secondary intention for small wound areas.
   Results: Patients managed with internal vacuum-assisted closure had wounds on average four times larger in area than patients managed without internal vacuum-assisted closure. In both groups, all wounds were eventually closed primarily. Healing times averaged 2.2 months with internal vacuum-assisted closure and 2.7 months without. At an average follow-up time of 2.3 months, all patients with internal vacuum-assisted closure had no recurrence of their local disease.
   Conclusions: Severe hidradenitis presents a treatment challenge, as surgical excisions are often complicated by difficult closures and unsatisfactory recurrence rates. This study demonstrates that wide local excision with reasonable outcomes can be achieved using accelerated delayed primary closure. This method uses internal vacuum-assisted closure as a bridge between excision and delayed primary closure, facilitating closure without recurrence in large, heavily contaminated wounds.
   CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.
C1 Beth Israel Deaconess Med Ctr, Dept Med, New York, NY 10003 USA.
   Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
   Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
   Massachusetts Gen Hosp, Dept Dermatol, Boston, MA 02114 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Georgetown University; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital
RP Orgill, DP (通讯作者)，75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019; Kimball, Alexana/M-6347-2019
OI Kimball, Alexana/0000-0001-9405-0479; Chen, Yiyin
   Erin/0000-0001-9452-1402; Verma, Kapil Dev/0000-0002-1163-2535
FU Kinetic Concepts, Inc.
FX Dr. Orgill has been an expert witness, consultant, and grant recipient
   of funding provided by Kinetic Concepts, Inc., the manufacturer of the
   V.A.C. devices mentioned in this article. The remaining authors have no
   financial interests to disclose.
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NR 36
TC 38
Z9 43
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAR
PY 2014
VL 133
IS 3
BP 370E
EP 377E
DI 10.1097/PRS.0000000000000080
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AD4TN
UT WOS:000333243600017
PM 24572882
DA 2026-07-24
ER
PT J
AU Kim, PJ
   Attinger, CE
   Steinberg, JS
   Evans, KK
   Powers, KA
   Hung, RW
   Smith, JR
   Rocha, ZM
   Lavery, L
AF Kim, Paul J.
   Attinger, Christopher E.
   Steinberg, John S.
   Evans, Karen K.
   Powers, Kelly A.
   Hung, Rex W.
   Smith, Jesse R.
   Rocha, Zinnia M.
   Lavery, Larry
TI The Impact of Negative- Pressure Wound Therapy with Instillation
   Compared with Standard Negative- Pressure Wound Therapy: A
   Retrospective, Historical, Cohort, Controlled Study
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; POLYHEXANIDE;
   INFECTIONS; EFFICACY; INSTILL(R); MANAGEMENT; DRESSINGS; BACTERIA;
   BETAINE
AB Background: Negative-pressure wound therapy with instillation is a novel wound therapy that combines negative pressure with instillation of a topical solution.
   Methods: This retrospective, historical, cohort-control study examined the impact of negative-pressure wound therapy with and without instillation.
   Results: One hundred forty-two patients (negative-pressure wound therapy, n = 74; therapy with instillation, 6-minute dwell time, n = 34; and therapy with instillation, 20-minute dwell time, n = 34) were included in the analysis. Number of operative visits was significantly lower for the 6- and 20-minute dwell time groups (2.4 0.9 and 2.6 0.9, respectively) compared with the no-instillation group (3.0 +/- 0.9) (p 0.05). Hospital stay was significantly shorter for the 20-minute dwell time group (11.4 +/- 5.1 days) compared with the no-instillation group (14.92 +/- 9.23 days) (p 0.05). Time to final surgical procedure was significantly shorter for the 6- and 20-minute dwell time groups (7.8 +/- 5.2 and 7.5 +/- 3.1 days, respectively) compared with the no-instillation group (9.23 +/- 5.2 days) (p 0.05). Percentage of wounds closed before discharge and culture improvement for Gram-positive bacteria was significantly higher for the 6-minute dwell time group (94 and 90 percent, respectively) compared with the no-instillation group (62 and 63 percent, respectively) (p 0.05).
   Conclusion: The authors' results suggest that negative-pressure wound therapy with instillation (6- or 20-minute dwell time) is more beneficial than standard negative-pressure wound therapy for the adjunctive treatment of acutely and chronically infected wounds that require hospital admission.
   CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.
C1 [Attinger, Christopher E.] Georgetown Univ Hosp, Dept Plast Surg, Washington, DC 20007 USA.
   Georgetown Univ, Sch Med, Washington, DC 20057 USA.
   Georgetown Univ, Med Ctr, Washington, DC 20057 USA.
   Univ Texas SW Med Ctr Dallas, Dept Plast Surg, Dallas, TX USA.
C3 Georgetown University; Georgetown University; Georgetown University;
   University of Texas System; University of Texas Southwestern Medical
   Center
RP Attinger, CE (通讯作者)，Georgetown Univ Hosp, Dept Plast Surg, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM cattinger@aol.com
OI Lavery, Lawrence/0000-0002-7920-9952; , Paul/0000-0002-6186-6890; Smith,
   Jesse/0000-0003-2221-2306; Evans, Karen/0000-0003-1056-2114
FU Kinetic Concepts, Inc
FX Dr. Kim is a consultant for Kinetic Concepts, Inc. Dr. Attinger is an
   uncompensated consultant for Kinetic Concepts, Inc. Dr. Lavery has
   received past research funding from Kinetic Concepts, Inc. The other
   authors have no financial interest to declare in relation to the content
   of this article.
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NR 29
TC 139
Z9 170
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAR
PY 2014
VL 133
IS 3
BP 709
EP 716
DI 10.1097/01.prs.0000438060.46290.7a
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AD4TN
UT WOS:000333243600071
PM 24572860
DA 2026-07-24
ER
PT J
AU Lavery, LA
   La Fontaine, J
   Thakral, G
   Kim, PJ
   Bhavan, K
   Davis, KE
AF Lavery, Lawrence A.
   La Fontaine, Javier
   Thakral, Gaurav
   Kim, Paul J.
   Bhavan, Kavita
   Davis, Kathryn E.
TI Randomized Clinical Trial to Compare Negative- Pressure Wound Therapy
   Approaches with Low and High Pressure, Silicone- Coated Dressing, and
   Polyurethane Foam Dressing
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID MICROVASCULAR BLOOD-FLOW; VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS;
   AREA; MULTICENTER
AB Background: This study was designed to compare two approaches to negative-pressure wound therapy: 125-mmHg pressure with a polyurethane foam dressing and 75-mmHg pressure with a silicone-coated dressing.
   Methods: Forty patients with diabetic foot wounds, after incision and drainage or amputation for infection, were assigned randomly to negative-pressure wound therapy with 75-mmHg continuous pressure with a silicone-covered dressing (75-mmHg group) or 125-mmHg with a polyurethane foam dressing (125-mmHg group) for up to 4 weeks or until surgical closure.
   Results: There was no difference in the proportion of wounds that were closed surgically (75-mmHg group, 50 percent; 125-mmHg group, 60 percent), wounds that demonstrated 50 percent wound area reduction (75-mmHg group, 65 percent; 125-mmHg group, 80 percent), or wounds that demonstrated 50 percent wound volume reduction after 4 weeks of therapy (75-mmHg group, 95 percent; 125-mmHg group, 90 percent).
   Conclusion: The authors' results suggest that there was no difference in outcomes in wounds treated with low pressure (75 mmHg) with a silicone-coated interface and high pressure (125 mmHg) with a polyurethane foam interface.
   CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
C1 [Lavery, Lawrence A.] Univ Texas SW Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
   Univ Texas SW Med Ctr Dallas, Dept Med, Dallas, TX 75390 USA.
   Georgetown Univ, Dept Plast Surg, Washington, DC USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas Southwestern
   Medical Center; Georgetown University
RP Lavery, LA (通讯作者)，Univ Texas SW Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd,F4-310A, Dallas, TX 75390 USA.
EM larry.lavery@utsouthwestern.edu
OI Lavery, Lawrence/0000-0002-7920-9952; , Paul/0000-0002-6186-6890
FU KCI; Osirus; Health Point; ThermoTek; Integra; GlaxoSmithKline;
   ConvaTec; Innovative Therapies, Inc; Smith and Nephew
FX Dr. Lavery has research grants from KCI, Osirus, Health Point,
   ThermoTek, Integra, GlaxoSmithKline, ConvaTec, and Innovative Therapies,
   Inc. He is on the speaker's bureau for Shire, KCI, and Innovative
   Technologies and is a consultant/advisor for Innovative Therapies and
   Pamlab, L. L. C. He has stock ownership in Diabetica Solutions and Prizm
   Medical and holds patents with Diabetica Solutions. Dr. Lafontaine has
   received research funding from Smith and Nephew, KCI, Innovative
   Therapies, Inc., and Convatec. He is on the speaker's bureau of Shire
   and Smith and Nephew. Dr. Davis has grants from ConvaTec and Innovative
   Therapies. Dr. Kim has research grants and serves on scientific advisory
   boards for KCI and Innovative Technologies. The remaining authors have
   no financial interests to disclose.
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NR 14
TC 32
Z9 43
U1 2
U2 38
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAR
PY 2014
VL 133
IS 3
BP 722
EP 726
DI 10.1097/01.prs.0000438046.83515.6a
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AD4TN
UT WOS:000333243600073
PM 24263388
DA 2026-07-24
ER
PT J
AU Fraccalvieri, M
   Fierro, MT
   Salomone, M
   Fava, P
   Zingarelli, EM
   Cavaliere, G
   Bernengo, MG
   Bruschi, S
AF Fraccalvieri, Marco
   Fierro, Maria Teresa
   Salomone, Marco
   Fava, Paolo
   Zingarelli, Enrico M.
   Cavaliere, Giovanni
   Bernengo, Maria G.
   Bruschi, Stefano
TI Gauze-based negative pressure wound therapy: a valid method to manage
   pyoderma gangrenosum
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Inflammatory ulcer; Negative pressure wound therapy; Pain; Pyoderma
   gangrenosum; Vacuum therapy
ID VACUUM-ASSISTED CLOSURE; DIAGNOSIS; TISSUE; FOAM
AB Pyoderma gangrenosum (PG) is an uncommon ulcerative, non-infective chronic inflammatory skin disorder of unknown aetiology. Systemic therapies are necessary to control the associated medical diseases, and, due to the inflammatory nature of PG, topical or systemic immunosuppressant agents are effective, but wound healing is usually slow. Negative wound pressure therapy (NPWT) has become an important tool for the management of complex skin ulcers, and usage in PG has been recently described in the literature: we present four cases of classic PG in which NPWT in association with systemic therapy achieved wound healing and a drastic pain reduction.
C1 [Fraccalvieri, Marco; Salomone, Marco; Zingarelli, Enrico M.; Bruschi, Stefano] Univ Turin, Dept Plast Surg, Turin, Italy.
   [Fierro, Maria Teresa; Fava, Paolo; Cavaliere, Giovanni; Bernengo, Maria G.] Univ Turin, Dept Biomed Sci & Human Oncol, Dermatol Sect, I-10124 Turin, Italy.
C3 University of Turin; University of Turin
RP Fraccalvieri, M (通讯作者)，Univ Turin, Dept Plast Surg, Via Cherasco 23, Turin, Italy.
EM marco@fraccalvieri.it
RI ; Fava, Paolo/A-1128-2019; /AAF-4387-2019
OI Bruschi, Stefano/0000-0002-4746-9864; FIERRO, MARIA
   TERESA/0000-0003-0996-6322; Fava, Paolo/0000-0002-8443-7458; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 23
TC 18
Z9 21
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2014
VL 11
IS 2
BP 164
EP 168
DI 10.1111/j.1742-481X.2012.01058.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AD7EF
UT WOS:000333424100009
PM 22891652
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Risnes, I
   Abdelnoor, M
   Veel, T
   Svennevig, JL
   Lundblad, R
   Rynning, SE
AF Risnes, Ivar
   Abdelnoor, Michael
   Veel, Terje
   Svennevig, Jan Ludvig
   Lundblad, Runar
   Rynning, Stein Erik
TI Mediastinitis after coronary artery bypass grafting: the effect of
   vacuum-assisted closure versus traditional closed drainage on survival
   and re-infection rate
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Coronary artery bypass grafting; Mediastinitis; Mortality; Re-infection;
   Traditional closed drainage; Vacuum-assisted closure
ID LONG-TERM SURVIVAL; STERNAL WOUND-INFECTION; RISK-FACTORS;
   POSTSTERNOTOMY MEDIASTINITIS; THERAPY; IMPACT; MORTALITY; SURGERY
AB Mediastinitis is treated with either vacuum-assisted closure (VAC) or traditional closed drainage (TCD) with irrigation. The aim of the study was to determine the effect of the two treatments on mortality and re-infection rate in a source population, using 21 314 consecutive patients undergoing isolated coronary artery bypass grafting (CABG) from January 1997 to October 2010. Median observation time was 2.9 years in the VAC group and 8.0 years in the TCD group. The epidemiological design was of an exposed (VAC, n = 64) versus non-exposed (TCD, n = 66) cohort with two endpoints: (1) mortality and (2) failure of sternal wound healing or re-infection. The crude effect of treatment technique versus endpoint was estimated by univariate analysis. Stratification analysis by the Mantel-Haenszel method was performed to quantify confounders and to pinpoint effect modifiers. Adjustment for confounders was performed using Cox regression analysis. Mediastinitis was diagnosed 6-105 (median 14) days after primary operation in the VAC group and 13 (5-29) days in the TCD group. There was no difference between groups in long-term survival. Failure of sternal wound healing or re-infection occurred less frequently in the VAC group (6%) than in the TCD group (21%; relative risk = 0.29, 95% CI = 0.06-0.88, P = 0.01). There are concerns for increase in right ventricle rupture in VAC compared with TCD. There was no difference in survival after VAC therapy and TCD therapy of post-CABG mediastinitis. Failure of sternal wound healing or re-infection was more common after TCD therapy.
C1 [Risnes, Ivar; Veel, Terje; Rynning, Stein Erik] Feiring Heart Clin, Feiring, Norway.
   [Abdelnoor, Michael] Oslo Univ Hosp, Unit Epidemiol & Biostat, Oslo, Norway.
   [Svennevig, Jan Ludvig; Lundblad, Runar] Oslo Univ Hosp, Dept Thorac & Cardiovasc Surg, Oslo, Norway.
C3 University of Oslo; University of Oslo
RP Risnes, I (通讯作者)，Feiring Heart Clin, Feiring, Norway.
EM ivar.risnes@feiringklinikken.no
RI abdelnoor, michael/K-4248-2019
CR Abboud CS, 2004, ANN THORAC SURG, V77, P676, DOI 10.1016/S0003-4975(03)01523-6
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NR 24
TC 25
Z9 35
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2014
VL 11
IS 2
BP 177
EP 182
DI 10.1111/j.1742-481X.2012.01060.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AD7EF
UT WOS:000333424100011
PM 22925188
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Allen, D
   LaBarbera, LA
   Bondre, IL
   Lessing, MC
   Rycerz, AM
   Kilpadi, DV
   Collins, BA
   Perkins, J
   McNulty, AK
AF Allen, Diwi
   LaBarbera, Lori A.
   Bondre, Ioana L.
   Lessing, M. Christian
   Rycerz, Anthony M., Jr.
   Kilpadi, Deepak V.
   Collins, Barbara A.
   Perkins, Joanna
   McNulty, Amy K.
TI Comparison of tissue damage, cleansing and cross-contamination potential
   during wound cleansing via two methods: lavage and negative pressure
   wound therapy with instillation
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Environmental cross-contamination; Lavage; NPWTi; Tissue trauma; Wound
   cleansing
ID VANCOMYCIN-RESISTANT ENTEROCOCCI; PULSATILE LAVAGE;
   ACINETOBACTER-BAUMANNII; ENVIRONMENTAL CONTAMINATION;
   STAPHYLOCOCCUS-AUREUS; SOFT-TISSUE; IRRIGATION; INFECTIONS; OUTBREAK;
   SYSTEM
AB The use of lavage was compared to negative pressure wound therapy (NPWT) with instillation (NPWTi) to assess extent of soft tissue damage, debris removal and environmental cross-contamination susceptibility in three distinct models. Scanning electron microscopy in an ex vivo model showed increased visible tissue trauma from lavage treatment at low and high pressures versus NPWTi, with the degree of trauma relative to the pressure of the irrigant. These results were corroborated in granulating full-thickness excisional swine wounds coated with dextran solution to simulate wound debris. Both low-pressure lavage and NPWTi demonstrated effective cleansing in this model, reducing debris by >90%. However, using three-dimensional photography to evaluate tissue damage by measuring immediate tissue swelling (changes in wound volume and depth) showed significantly greater (P < 0.05) swelling in low-pressure lavage-treated wounds compared with NPWTi-treated wounds. Lastly, bench top wound models were inoculated with fluorescent bacterial particles to assess environmental cross-contamination potential and collected at measured distances after treatment with low-pressure lavage and NPWTi. No evidence of cross-contamination was found with NPWTi, whereas one-half of the particles became aerosolised' during low-pressure lavage (P < 0.05). Collectively, these studies demonstrate the effective wound cleansing capabilities of NPWTi without the tissue damage and environmental contamination associated with lavage.
C1 [Allen, Diwi; LaBarbera, Lori A.; Bondre, Ioana L.; Lessing, M. Christian; Rycerz, Anthony M., Jr.; Kilpadi, Deepak V.; Collins, Barbara A.; Perkins, Joanna; McNulty, Amy K.] Kinet Concepts Inc, Act Healing Solut Appl Sci, San Antonio, TX 78249 USA.
RP Allen, D (通讯作者)，Kinet Concepts Inc, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM diwi.allen@kci1.com
RI ; Bondre, Ioana/GXF-4790-2022
OI Lessing, Chris/0009-0001-5009-6624; 
FU KCI
FX The authors would like to thank the staff at Surpass preclinical
   facility for their assistance with wound creation and cleansing
   therapies; A. Jimenez of Vel-Lab Research for histology processing; M.
   Manwaring of KCI for his help with the wound template for the ex vivo
   wound model portion of the study and Z. Liu of KCI for statistical
   analyses. This study was supported by KCI. Many of the authors are
   employees of KCI. All authors report no other conflicts of interest
   relevant to this study.
CR Adili A, 2002, J ORTHOP TRAUMA, V16, P413, DOI 10.1097/00005131-200207000-00008
   [Anonymous], COCHRANE DATABASE SY
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   Snyder GM, 2008, INFECT CONT HOSP EP, V29, P583, DOI 10.1086/588701
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NR 30
TC 28
Z9 34
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2014
VL 11
IS 2
BP 198
EP 209
DI 10.1111/j.1742-481X.2012.01073.x
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AD7EF
UT WOS:000333424100014
PM 22905800
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Lee, KT
   Pyon, JK
   Lim, SY
   Mun, GH
   Oh, KS
   Bang, SI
AF Lee, Kyeong-Tae
   Pyon, Jai-Kyong
   Lim, So-Young
   Mun, Goo-Hyun
   Oh, Kap Sung
   Bang, Sa-Ik
TI Negative-pressure wound dressings to secure split-thickness skin grafts
   in the perineum
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative-pressure dressing; Perineum; Split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; MANAGEMENT; THERAPY;
   DEVICE; TRIAL; BED
AB Several researches have shown that negative-pressure wound dressings can secure split-thickness skin grafts and improve graft survival. However, in anatomically difficult body regions such as the perineum it is questionable whether these dressings have similar beneficial effects. In this study, we evaluated the effects of negative-pressure wound dressings on split-thickness skin grafts in the perineum by comparing wound healing rate and complication rate with that of tie-over dressings. A retrospective chart review was performed for the patients who underwent a split-thickness skin graft to reconstruct perineal skin defects between January 2007 and December 2011. After grafting, the surgeon selected patients to receive either a negative-pressure dressing or a tie-over dressing. In both groups, the initial dressing was left unchanged for 5 days, then changed to conventional wet gauze dressing. Graft success was assessed 2 weeks after surgery by a single clinician. A total of 26 patients were included in this study. The mean age was 56.6 years and the mean wound size was 273.1 cm(2). Among them 14 received negative-pressure dressings and 12 received tie-over dressings. Negative-pressure dressing group had higher graft taken rate (P = 0.036) and took shorter time to complete healing (P = 0.01) than tie-over dressing group. The patients with negative-pressure dressings had a higher rate of graft success and shorter time to complete healing, which has statistical significance. Negative-pressure wound dressing can be a good option for effective management of skin grafts in the perineum.
C1 [Lee, Kyeong-Tae; Pyon, Jai-Kyong; Lim, So-Young; Mun, Goo-Hyun; Oh, Kap Sung; Bang, Sa-Ik] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Plast Surg, Seoul 135710, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Bang, SI (通讯作者)，Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Plast Surg, Ilwon Dong 50, Seoul 135710, South Korea.
EM skymaker26@gmail.com
RI Lee, Kyeong-Tae/AAJ-2478-2021; Mun, Goo-Hyun/I-2540-2019
CR Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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NR 17
TC 18
Z9 25
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2014
VL 11
IS 2
BP 223
EP 227
DI 10.1111/j.1742-481X.2012.01078.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AD7EF
UT WOS:000333424100017
PM 22958590
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Hurd, T
   Trueman, P
   Rossington, A
AF Hurd, Theresa
   Trueman, Paul
   Rossington, Alan
TI Use of a Portable, Single-use Negative Pressure Wound Therapy Device in
   Home Care Patients with Low to Moderately Exuding Wounds: A Case Series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case reports; negative-pressure wound therapy; wounds; community health
   care
ID ASSISTED CLOSURE VAC; COST-EFFECTIVENESS; MULTICENTER; TRIAL
AB Negative pressure wound therapy (NPWT) is widely used in the management of acute and chronic wounds. The purpose of this 8-week study was to evaluate outcomes of using a new canisterless, portable, single-use NPWT system in patients with wounds treated in a Canadian community healthcare setting. The device is designed to provide negative pressure at 80 +/- 20 mm Hg, 24 hours a day of continuous usage, for a maximum wear time of 7 days. Data on wound outcomes, including exudate levels, wound appearance, and wound area, were collected weekly by a Registered Nurse as part of routine practice. When treatment was discontinued, patients and nurses were asked to rate their satisfaction with the device. Data from patients who had used a conventional NPWT device to manage their wounds were retrospectively abstracted from their medical records. In the prospective study, conducted between October 2011 and July 2012,326 patients (median age = 61 years; range 17-91 years) with wounds of mixed etiology (53 pressure ulcers, 21 venous leg ulcers, 16 diabetic foot ulcers, and 15 traumatic and 221 surgical wounds) were treated for a maximum of 8 weeks with the portable NPWT device. The majority of patients (228 out of 326; 68%) achieved complete wound closure within 8 weeks of treatment. The Kaplan-Meier estimate of median time to healing of all wounds was 9 weeks. The majority of patients (318 patients, 97%) reported they were pleased or satisfied with the dressing performance. Nurses indicated satisfaction with the dressing performance for all but two patients (99%). The majority (89%) of patients managed with conventional, NPWT (n = 539) had an open surgical wound with moderate or high levels of exudate. Healing rates in the portable and conventional NPWT group were similar (10% to 11% per week). Portable, single-use NPWT has the potential to deliver good wound outcomes in community care settings and simplify the use of negative pressure for nurses and patients. Additional research is needed to evaluate treatment efficacy and cost effectiveness.
C1 [Hurd, Theresa] Nursing Practice Solut, Toronto, ON, Canada.
   [Rossington, Alan] Smith & Nephew, Stat & Data Programme, Kingston Upon Hull HU3 2BN, N Humberside, England.
C3 Smith & Nephew
RP Trueman, P (通讯作者)，Smith & Nephew, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM paul.trueman@smith-nephew.com
OI Roldán Díaz, Irene/0009-0008-3975-8085
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Borgquist O, 2011, OSTOMY WOUND MANAG, V57, P44
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NR 18
TC 33
Z9 33
U1 0
U2 12
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAR
PY 2014
VL 60
IS 3
BP 30
EP 36
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AD9FU
UT WOS:000333571000004
PM 24610558
DA 2026-07-24
ER
PT J
AU Tuncel, U
   Turan, A
   Markoc, F
   Erkorkmaz, U
   Elmas, C
   Kostakoglu, N
AF Tuncel, Umut
   Turan, Aydin
   Markoc, Fatma
   Erkorkmaz, Unal
   Elmas, Cigdem
   Kostakoglu, Naci
TI Loofah Sponge as an Interface Dressing Material in Negative Pressure
   Wound Therapy: Results of an In Vivo Study
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE in vivo; loofah; negative pressure wound therapy; gauze; foam
ID VACUUM-ASSISTED CLOSURE; EVIDENCE-BASED RECOMMENDATIONS; GOURD
   LUFFA-CYLINDRICA; PORE-SIZE; CONTRACTION; GAUZE; FOAM; TRANSDUCTION;
   PROLIFERATION; ANGIOGENESIS
AB Since the introduction of negative pressure wound therapy (NPWT), the physiological effects of various interface dressing materials have been studied. The purpose of this experimental study was to compare the use of loofah sponge to standard polyurethane foam or a cotton gauze sponge. Three wounds, each measuring 3 cm x 3 cm, were created by full-thickness skin excision on the dorsal sides of 24 New Zealand adult white rabbits. The rabbits were randomly divided into four groups of six rabbits each. In group 1 (control), conventional saline-moistened gauze dressing was provided and changed at daily intervals. The remaining groups were provided NPWT dressings at -125 mm Hg continuous pressure. This dressing was changed every 3 days for 9 days; group 2 was provided polyurethane foam, group 3 had conventional saline-soaked antimicrobial gauze, and group 4 had loofah sponge. Wound area measurements and histological findings (inflammation, granulation tissue, neovascularization, and reepithelialization) were analyzed on days 3, 6, and 9. Wound area measurements at these intervals were significantly different between the control group and study groups (P <0.05). Granulation and neovascularization scores were also significantly different between the control and treatment groups at day 3 (P = 0.002). No differences in any of the healing variables studied were observed between the other three dressing materials. According to scanning electron microscopy analysis of the three interface materials, the mean pore size diameter of foam and gauze interface materials was 415.80 +/- 217.58 mu m and 912.33 +/- 116.88 mu m, respectively. The pore architecture of foam was much more regular than that of gauze. The average pore size diameter of loofah sponge was 736.83 +/- 23.01 mu m; pores were hierarchically located - ie, the smaller ones were usually peripheral and larger ones were central. For this study, the central part of loofah sponge was discarded to achieve a more homogenous structure of interface material. Loofah sponge study results were similar to those using gauze or foam, but the purchase price of loofah sponge is lower than that of currently available interface dressings. More experimental, randomized controlled studies are needed to confirm these results.
C1 [Tuncel, Umut; Turan, Aydin; Markoc, Fatma] Gaziosmanpasa Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, TR-60100 Tokat, Turkey.
   [Erkorkmaz, Unal] Sakarya Univ, Fac Med, Dept Biostat, Sakarya, Turkey.
   [Elmas, Cigdem] Gazi Med Sch, Dept Histol & Embryol, Ankara, Turkey.
   [Kostakoglu, Naci] Gaziosmanpasa Univ, Dept Plast Reconstruct & Aesthet Surg, TR-60100 Tokat, Turkey.
C3 Tokat Gaziosmanpasa University; Sakarya University; Gazi University;
   Tokat Gaziosmanpasa University
RP Tuncel, U (通讯作者)，Gaziosmanpasa Univ, Fac Med Plast Reconstruct & Aesthet Surg, TR-60100 Tokat, Turkey.
EM drumuttuncel@gmail.com
RI Turan, Aydın/V-6669-2017; Tuncel, Umut/P-3185-2015; Erkorkmaz,
   Ünal/AAA-4241-2022; Elmas, Cigdem/AHE-1281-2022
OI Turan, Aydın/0000-0002-1540-1443; Tuncel, Umut/0000-0001-5029-2927;
   Erkorkmaz, Ünal/0000-0002-8497-4704; 
FU Scientific Research Projects Unit, Gaziosmanpasa University, Tokat,
   Turkey
FX This study was supported by a grant from the Scientific Research
   Projects Unit, Gaziosmanpasa University, Tokat, Turkey. KCI, San
   Antonio, TX, provided technical and device support.
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NR 58
TC 13
Z9 14
U1 0
U2 12
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAR
PY 2014
VL 60
IS 3
BP 37
EP 45
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AD9FU
UT WOS:000333571000005
PM 24610559
DA 2026-07-24
ER
PT J
AU Wedemeyer, J
   Memming, M
   Schmidt, M
AF Wedemeyer, J.
   Memming, M.
   Schmidt, M.
TI Endoskopische Therapie der osophagusleckage
SO ENDOSKOPIE HEUTE
LA German
DT Article
DE osophagus; Endo-VAC; OTSC; Anastomosenleckage; selbstexpandierender
   Stent; selfexpanding stent; OTSC; anastomotic leakage; Endo-VAC;
   esophagus
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE ESOPHAGEAL LEAKS; EXPANDING
   PLASTIC STENTS; ENDOSCOPIC CLOSURE; ANASTOMOTIC LEAKS; METAL STENTS;
   PERFORATIONS; SYSTEM; OTSC
AB Postsurgical leakages after resections of the esophagus are associated with high morbidity and mortality. Endoscopic therapy has gained increasingly acceptance and has almost completely replaced surgical revision. Placement of self expanding stents is the best established endoscopic treatment option for esophageal leakages. A new development is the endoscopic placement of vacuum sponge systems. Which have been adapted from VAC therapy for extensive infected skin defects. The development of over the scope clips (OTSC) provides another endoscopic treatment modality for esophageal leaks. Comprehensive knowledge of the various methods and their advantages as well as their limitations and drawbacks is necessary to provide optimal endoscopic care in these critically situations.
C1 [Wedemeyer, J.; Schmidt, M.] KRH Klinikum Robert Koch Gehrden, Med Klin 1, Schwerpunkt Gastroenterol & Hepatol, D-30989 Gehrden, Germany.
   [Memming, M.] KRH Klinikum Robert Koch Gehrden, D-30989 Gehrden, Germany.
RP Wedemeyer, J (通讯作者)，KRH Klinikum Robert Koch Gehrden, Med Klin 1, Schwerpunkt Gastroenterol & Hepatol, Von Reden Str 1, D-30989 Gehrden, Germany.
EM jochen.wedemeyer@krh.eu
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NR 22
TC 0
Z9 0
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0933-811X
EI 1439-2577
J9 ENDOSKOPIE HEUTE
JI Endoskopie Heute
PD MAR
PY 2014
VL 27
IS 1
BP 17
EP 21
DI 10.1055/s-0034-1366189
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA AE0HK
UT WOS:000333644300004
DA 2026-07-24
ER
PT J
AU Osterhoff, G
   Zwolak, P
   Krüger, C
   Wilzeck, V
   Simmen, HP
   Jukema, GN
AF Osterhoff, Georg
   Zwolak, Pawel
   Krueger, Carmen
   Wilzeck, Verena
   Simmen, Hans-Peter
   Jukema, Gerrolt N.
TI Risk factors for prolonged treatment and hospital readmission in 280
   cases of negative-pressure wound therapy
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; Vacuum-assisted closure; Open
   fractures; Risk factors; Wound healing
ID VACUUM-ASSISTED CLOSURE; MECHANISMS
AB Background: There is evidence of certain beneficial effects and increasing understanding of the mechanisms of action of negative-pressure wound therapy (NPWT). However, it is known that prolonged duration of NPWT is associated with increased bacterial growth and efforts should be made to decrease the duration of NPWT. It was the aim of this study to evaluate potential risk factors for the duration, from first application of NPWT to secondary wound closure and to identify factors that increase the rate of hospital readmission.
   Methods: In a retrospective cohort study, 261 patients (46 +/- 19 years, 70 female) who underwent 280 treatments with NPWT were analysed. Patient-specific and demographic characteristics and the presence of several risk factors were documented. The duration of treatment from first application of NPWT to secondary wound closure, the number of interventions, the duration of hospital stay and the incidence of readmissions due to complications of the wound treated by NPWT were recorded and a risk factor analysis was performed.
   Results: The median number of NPWT procedures was 2.0 +/- 2.0, the duration of NPWT was 6.0 +/- 14.7 days and the length of hospital stay was 16.0 +/- 27.9 days. Presence of an open fracture (p = .002) and increased age (p = .004) were identified as independent risk factors for a prolonged duration of NPWT. Patients who smoked (p = .001) or patients with alcohol/drug abuse (p = .015) were more likely to return to hospital (smoking: 18 out of 58 cases; alcohol/drug abuse: 7 out of 19 cases). No such association was seen for diabetes (p = .702), peripheral vascular disease (PVD) (p = .052), immunosuppressive medication (p = .187), immunodeficiency (p = .404), trauma (p = .358), infection (p = .298) and open fracture (p = .061).
   Conclusions: Patient age and presence of an open fracture are independent predictors of a prolonged duration from first application of NPWT to secondary wound closure. These results should be taken into account for the calculation of average costs and anticipated hospital stay associated with this therapy. (C) 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Osterhoff, Georg; Zwolak, Pawel; Krueger, Carmen; Wilzeck, Verena; Simmen, Hans-Peter; Jukema, Gerrolt N.] Univ Zurich, Div Trauma Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich
RP Osterhoff, G (通讯作者)，Univ Zurich Hosp, Div Trauma Surg, Dept Surg, Raemistr 100, CH-8091 Zurich, Switzerland.
EM georg.osterhoff@usz.ch
RI ; Osterhoff, Georg/IXW-9149-2023
OI Simmen, Hans-Peter/0000-0002-5201-4549; Osterhoff,
   Georg/0000-0001-5051-0998
CR [Anonymous], GER MED SCI
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NR 20
TC 18
Z9 18
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAY
PY 2014
VL 67
IS 5
BP 629
EP 633
DI 10.1016/j.bjps.2014.01.010
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AE2OE
UT WOS:000333811800016
PM 24507965
DA 2026-07-24
ER
PT J
AU Penny, HL
   Spinazzola, J
   Green, A
   Rifkah, M
   Faretta, M
   Youshaw, D
   Weaver, A
   Zaki, P
AF Penny, H. L.
   Spinazzola, J.
   Green, A.
   Rifkah, M.
   Faretta, M.
   Youshaw, D.
   Weaver, A.
   Zaki, P.
TI Negative pressure wound therapy with Bio-Dome dressing technology in the
   treatment of complex wounds: A case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; chronic wounds; wound size reduction;
   wound volume reduction
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL
AB The treatment of complex wounds is difficult and not always effective. Various treatment options are used with varying degrees of success. Negative pressure wound therapy (NPWT) is a cost-efficient and effective way to help treat these wounds. The use of a vacuum device applies the negative pressure to the site of the wound and promotes waste removal and increases circulation and tissue formation. While various NPWT systems are currently on the market, we utilised the ConvaTec Engenex (R) system with Bio-Dome(TM) technology; however, our case study is not intended to advocate the specific use of this system, but instead focusses on the use of NPWT as a viable option for wound healing. Each of the following case study patients presented with difficult-to-heal wounds that failed traditional therapeutic approaches. Through the use of NPWT, our patients saw major wound size reductions. Each patient exhibited at least a 94% reduction in wound area, wound volume or both.
C1 [Penny, H. L.; Youshaw, D.] Blair Med Associates Podiatry Dept, Altoona, PA 16602 USA.
   [Spinazzola, J.] Penn State Hershey Med Ctr, Hershey, PA USA.
   [Green, A.] Hofstra Univ, Sch Med, Hofstra North Shore LIJ, Hempstead, NY 11550 USA.
   [Rifkah, M.] Marshall Univ, Sch Med, Huntington, WV USA.
   [Faretta, M.] Commonwealth Med Coll, Scranton, PA USA.
   [Weaver, A.] Juniata Coll, Duncansville, PA USA.
   [Zaki, P.] Penn State Univ, Hollidaysburg, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Hofstra University;
   Marshall University; Geisinger Commonwealth School of Medicine;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University
RP Penny, HL (通讯作者)，Blair Med Associates Podiatry Dept, Altoona, PA 16602 USA.
EM hpenny@bma.md
CR Ahearn C, 2009, OSTOMY WOUND MANAG, V55, P22
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Baldwin C, 2009, ANN PLAS SURG, V62, P92, DOI 10.1097/SAP.0b013e31817762fd
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NR 12
TC 1
Z9 1
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2014
VL 23
IS 4
BP S4
EP S9
DI 10.12968/jowc.2014.23.Sup4.S4
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AE3AV
UT WOS:000333848600002
PM 24762555
DA 2026-07-24
ER
PT J
AU Anagnostakos, K
   Mosser, P
AF Anagnostakos, K.
   Mosser, P.
TI Negative pressure wound therapy in the management of postoperative
   infections after musculoskeletal tumour surgery
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; infections; musculoskeletal tumour
   surgery
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE SARCOMA; COMPLICATIONS;
   RADIOTHERAPY; EXTREMITY; STATE
AB Objective: The aim of the present retrospective study was to report on the effectiveness of the negative pressure wound therapy (NPWT) in the treatment of infected wounds after musculoskeletal tumour surgery.
   Method: A total of 12 patients (10 male, 2 female, mean age 44.9 years with 9 early and 3 late infections) were included in the study. Patient parameters measured include age, gender, tumour diagnosis and localisation, pathogen organism, foam used, pressure height and modus, number of NPWT dressings changes, total duration of NPWT, need for secondary wound closure, length of hospitalisation, complications, and follow-up.
   Results: The NPWT dressings were changed on average 6.7 (SD +/- 6.9) times after a mean duration of 5.6 (SD +/- 2.4) days. The total duration of NPWT was 37.7 (SD +/- 32.9)days. The mean hospital stay was 77.5 (SD +/- 58.8) days. In 7 out of 12 cases, a split-thickness skin graft transplantation was performed. In these cases, no seroma or hematoma formation beneath the skin graft could be observed. At a mean follow-up 39.2 (range: 9-73) months, no reinfection or infection persistence was apparent.
   Conclusion: NPWT can be of valuable assistance in the treatment of infected wounds following musculoskeletal tumour surgery. The patients should be informed about the long treatment period.
C1 [Anagnostakos, K.; Mosser, P.] Univ Hosp Saarland, Dept Orthopaed Surg, Homburg, Germany.
C3 Universitatsklinikum des Saarlandes
RP Anagnostakos, K (通讯作者)，Univ Hosp Saarland, Dept Orthopaed Surg, Homburg, Germany.
EM k.anagnostakos@web.de
RI Anagnostakos, Konstantinos/MGC-8753-2025
CR Anagnostakos K, 2012, J WOUND CARE, V21, P333, DOI 10.12968/jowc.2012.21.7.333
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NR 29
TC 5
Z9 5
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2014
VL 23
IS 4
BP 191
EP 197
DI 10.12968/jowc.2014.23.4.191
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AE3AV
UT WOS:000333848600006
PM 24762382
DA 2026-07-24
ER
PT J
AU Pellino, G
   Sciaudone, G
   Candilio, G
   Campitiello, F
   Selvaggi, F
   Canonico, S
AF Pellino, Gianluca
   Sciaudone, Guido
   Candilio, Giuseppe
   Campitiello, Ferdinando
   Selvaggi, Francesco
   Canonico, Silvestro
TI Effects of a New Pocket Device for Negative Pressure Wound Therapy on
   Surgical Wounds of Patients Affected With Crohn's Disease: A Pilot Trial
SO SURGICAL INNOVATION
LA English
DT Article
DE negative pressure wound therapy; instrumentation; methods; patient
   satisfaction; wound healing; surgical site infections; Crohn's disease
ID INFLAMMATORY-BOWEL-DISEASE; VACUUM-ASSISTED CLOSURE; SITE INFECTION;
   INTESTINAL WALL; OPEN ABDOMEN; PREVENTION; SURGERY; PROPHYLAXIS;
   INCISIONS; LAPAROSTOMY
AB Introduction. Surgical site infections (SSIs) affect costs of care and prolong length of stay. Crohn's disease (CD) represents an independent risk factor for SSI. The risk can be further increased by concomitant administration of immunosuppressive drugs and poor performance status at the time of surgery. Patients suffering from CD often need more than one surgical intervention during life, sometimes requiring fashioning of a stoma. The aim of this pilot study was to compare a portable device for negative pressure wound therapy (PICO, Smith & Nephew, London, UK) to conventional gauze dressings in patients undergoing surgery for stricturing CD. Methods. Between January 2010 and November 2011, this controlled trial enrolled 30 patients, who were assigned to treatment with either PICO (n = 13) or conventional dressings (n = 17). Each patient completed a 3-month follow-up. Results. Patients receiving PICO experienced significantly less postoperative wound complications (P = .001) and SSI (P = .017) compared with those who received conventional dressings. This resulted in shorter hospital stay (P = .0007). No significant differences in cosmetic results were found. Conclusion. These data suggest that PICO allows faster and safe discharge by reducing the incidence of SSI and wound-related complications in selected patients undergoing surgical intervention for stricturing CD. This could be particularly useful in patients receiving steroids.
C1 [Pellino, Gianluca; Sciaudone, Guido; Candilio, Giuseppe; Campitiello, Ferdinando; Selvaggi, Francesco; Canonico, Silvestro] Univ Naples 2, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Selvaggi, F (通讯作者)，Univ Naples 2, Dept Surg, Piazza Miraglia 5, I-80138 Naples, Italy.
EM fselvaggi@hotmail.com
RI ; Selvaggi, Francesco/HSH-7500-2023; Pellino, Gianluca/B-8458-2015
OI SCIAUDONE, Guido/0000-0003-4221-8502; Selvaggi,
   Francesco/0000-0002-3219-3797; Pellino, Gianluca/0000-0002-8322-6421
FU Smith & Nephew, London, United Kingdom
FX The Chief of the Unit where the study was carried out received a funding
   from Smith & Nephew, London, United Kingdom, to buy the devices employed
   in the present study. Results were not submitted or shown to Smith &
   Nephew.
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NR 37
TC 53
Z9 54
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD APR
PY 2014
VL 21
IS 2
BP 204
EP 212
DI 10.1177/1553350613496906
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AF2WR
UT WOS:000334573700022
PM 23883481
DA 2026-07-24
ER
PT J
AU Morodomi, Y
   Takenoyama, M
   Yamaguchi, M
   Inamasu, E
   Yoshida, T
   Kawano, D
   Okamoto, T
   Inoue, Y
   Maehara, Y
   Ichinose, Y
AF Morodomi, Yosuke
   Takenoyama, Mitsuhiro
   Yamaguchi, Masafumi
   Inamasu, Eiko
   Yoshida, Tsukihisa
   Kawano, Daigo
   Okamoto, Tatsuro
   Inoue, Yojiro
   Maehara, Yoshihiko
   Ichinose, Yukito
TI Application of Continuous Negative Pressure Irrigation and Negative
   Pressure Fixation to Treat a Bronchopleural Fistula with Thoracic
   Empyema
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Thoracic empyema with a bronchopleural fistula (BPF) represents a highly lethal and intractable clinical condition after thoracic surgery. Mortality associated with BPF is estimated to be 27% to 71%.(1,2) Death is attributed to difficulty in removing bacteria from the thoracic cavity and contralateral pneumonia due to aspiration of bacteria.
   The key to controlling wound infection is debridement and lavage. Under these conditions, the lack of blood flow and presence of a high number of bacteria at the wound site prevent normal granulation. Bronchopleural fistula makes it impossible to lavage the wound because of the high risk of causing aspiration pneumonia in the remaining lungs due to the presence of lavage liquid.
   When infection and granulation are controlled and wound bed preparation is complete, thoracoplasty is often performed to close BPF using a muscle flap or omentum. However, the flap or omentum can occasionally be too unstable to be fixed due to coughing, and pooled sputum or infectious discharge around a BPF can prevent closure of the fistula.
   Here, we present a novel and safe technique that enables negative pressure wound therapy (NPWT) and BPF irrigation to promote granulation and fistula closure. In addition, we present a negative pressure fixation system after thoracoplasty.
C1 [Morodomi, Yosuke; Kawano, Daigo; Okamoto, Tatsuro; Maehara, Yoshihiko] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka 8128582, Japan.
   [Takenoyama, Mitsuhiro; Yamaguchi, Masafumi; Inamasu, Eiko; Yoshida, Tsukihisa; Ichinose, Yukito] Kyushu Natl Canc Ctr, Dept Thorac Oncol, Fukuoka, Japan.
   [Inoue, Yojiro] Kyushu Natl Canc Ctr, Dept Plast & Reconstruct Surg, Fukuoka, Japan.
C3 Kyushu University
RP Morodomi, Y (通讯作者)，Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM yo-suke@surg2.med.kyushu-u.ac.jp
OI Morodomi, Yosuke/0000-0002-8882-0833
CR Asai K, 2006, GEN THORAC CARDIOVAS, V54, P507, DOI 10.1007/s11748-006-0045-y
   ASAMURA H, 1992, J THORAC CARDIOV SUR, V104, P1456
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   Owens BD, 2007, J BONE JOINT SURG AM, V89A, P1723, DOI 10.2106/JBJS.F.01210
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NR 9
TC 3
Z9 6
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD MAY
PY 2014
VL 218
IS 5
BP E87
EP E90
DI 10.1016/j.jamcollsurg.2013.12.053
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AF2ZS
UT WOS:000334581600001
PM 24745581
DA 2026-07-24
ER
PT J
AU Lee, JY
   Jung, H
   Kwon, H
   Jung, SN
AF Lee, Jun Yong
   Jung, Hyunwook
   Kwon, Ho
   Jung, Sung-No
TI Extended negative pressure wound therapy-assisted dermatotraction for
   the closure of large open fasciotomy wounds in necrotizing fasciitis
   patients
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Necrotizing fasciitis; Negative pressure wound therapy; Dermatotraction;
   Fournier's gangrene; Fasciotomy
ID SHOELACE TECHNIQUE; MANAGEMENT; DIAGNOSIS; LIMB
AB Background: Necrotizing fasciitis (NF) is a rapid progressive infection of the subcutaneous tissue or fascia and may result in large open wounds. The surgical options to cover these wounds are often limited by the patient condition and result in suboptimal functional and cosmetic wound coverage. Dermatotraction can restore the function and appearance of the fasciotomy wound and is less invasive in patients with comorbidities. However, dermatotraction for scarred, stiff NF fasciotomy wounds is often ineffective, resulting in skin necrosis. The authors use extended negative pressure wound therapy (NPWT) as an assist in dermatotraction to close open NF fasciotomy wounds. The authors present the clinical results, followed by a discussion of the clinical basis of extended NPWT-assisted dermatotraction.
   Methods: A retrospective case series of eight patients with NF who underwent open fasciotomy was approved for the study. After serial wound preparation, dermatotraction was applied in a shoelace manner using elastic vessel loops. Next, the extended NPWT was applied over the wound. The sponge was three times wider than the wound width, and the transparent covering drape almost encircled the anatomical wound area. The negative pressure of the NPWT was set at a continuous 100 mmHg by suction barometer. The clinical outcome was assessed based on wound area reduction after treatment and by the achievement of direct wound closure.
   Results: After the first set of extended NPWT-assisted dermatotraction procedures, the mean wound area was significantly decreased (658.12 cm(2) to 29.37 cm(2); p = 0.002), as five out of eight patients achieved direct wound closure. One patient with a chest wall defect underwent latissimus dorsi musculocutaneous flap coverage, with primary closure of the donor site. Two Fournier's gangrene patients underwent multiple sets of treatment and finally achieved secondary wound closure with skin grafts. The patients were followed up for 18.3 months on average and showed satisfactory results without wound recurrence.
   Conclusions: Extended NPWT-assisted dermatotraction advances scarred, stiff fasciotomy wound margins synergistically in NF and allows direct closure of the wound without complications. This method can be another good treatment option for the NF patient with large open wounds whose general condition is unsuitable for extensive reconstructive surgery.
C1 [Lee, Jun Yong] Catholic Univ Korea, Incheon St Marys Hosp, Dept Plast & Reconstruct Surg, Inchon 403720, South Korea.
   [Jung, Hyunwook; Kwon, Ho; Jung, Sung-No] Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Plast & Reconstruct Surg, Uijeongbu Si 480717, Gyeonggi Do, South Korea.
C3 Catholic University of Korea; Catholic University of Korea
RP Jung, SN (通讯作者)，Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Plast & Reconstruct Surg, 271 Cheonbo Ro, Uijeongbu Si 480717, Gyeonggi Do, South Korea.
EM jsn7190@catholic.ac.kr
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NR 28
TC 44
Z9 53
U1 0
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD APR 15
PY 2014
VL 9
AR 29
DI 10.1186/1749-7922-9-29
PG 10
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA AF6DR
UT WOS:000334805100001
PM 24731449
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Olona, C
   Duque, E
   Caro, A
   Jiménez, A
   Moreno, F
   Coronas, JM
   Vicente, V
AF Olona, Carles
   Duque, Enric
   Caro, Aleidis
   Jimenez, Andrea
   Moreno, Felix
   Coronas, Jose M.
   Vicente, Vicente
TI Negative-Pressure Therapy in the Postoperative Treatment of Incisional
   Hernioplasty Wounds: A Pilot Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative pressure therapy; incisional hernioplasty; seroma
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISIONS; OPEN ABDOMEN; REPAIR; WALL;
   EXPERIENCE; MANAGEMENT; MECHANISMS; MESH
AB Negative pressure therapy has proven useful in the treatment of the complex complications of surgical wounds. In this pilot study, the authors found that the negative pressure system can be used safely in the postoperative period of incisional hernia surgery and reduces the number of days of drainage.
C1 [Olona, Carles; Duque, Enric; Jimenez, Andrea; Moreno, Felix; Coronas, Jose M.; Vicente, Vicente] Joan XXIII Univ Hosp, Gen & Digest Surg Dept, Tarragona, Spain.
   [Caro, Aleidis] Parc Tauli Univ Hosp, Gen & Digest Surg Dept, Sabadell, Spain.
C3 Autonomous University of Barcelona; Parc Tauli Hospital Universitari
RP Olona, C (通讯作者)，Joan XXIII Univ Hosp, Gen & Digest Surg Dept, Tarragona, Spain.
RI ; JimenezFranco, Andrea/PCR-9372-2025; Vicente, Vicente/L-6185-2019
OI Caro, Aleidis/0000-0001-6151-3879; Vicente, Vicente/0000-0002-4278-3264
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NR 23
TC 19
Z9 20
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD FEB
PY 2014
VL 27
IS 2
BP 77
EP 80
DI 10.1097/01.ASW.0000442873.48590.b5
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA AG4KE
UT WOS:000335387600006
PM 24440865
DA 2026-07-24
ER
PT J
AU Marinis, A
   Gkiokas, G
   Argyra, E
   Fragulidis, G
   Polymeneas, G
   Voros, D
AF Marinis, A.
   Gkiokas, G.
   Argyra, E.
   Fragulidis, G.
   Polymeneas, G.
   Voros, D.
TI "ENTEROATMOSPHERIC FISTULAE"-GASTROINTESTINAL OPENINGS IN THE OPEN
   ABDOMEN: A REVIEW AND RECENT PROPOSAL OF A SURGICAL TECHNIQUE
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Review
DE Enteroatmospheric; fistula; open abdomen; vacuum-assisted therapy;
   vacuum-assisted closure; enterocutaneous; enteric fistula
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM PACK TECHNIQUE; SMALL-BOWEL
   FISTULAS; ENTEROCUTANEOUS FISTULAS; EXPOSED FISTULA; MANAGEMENT; WOUNDS;
   SEPSIS
AB The occurrence of an enteric fistula in the middle of an open abdomen is called an enteroatmospheric fistula, which is the most challenging and feared complication for a surgeon to deal with. It is in fact not a true fistula because it neither has a fistula tract nor is covered by a well-vascularized tissue. The mortality of enteroatmospheric fistulae was as high as 70% in past decades but is currently approximately 40% due to advanced modern intensive care and improved surgical techniques. Management of patients with an open abdomen and an enteroatmospheric fistula is very challenging. Intensive care support of organs and systems is vital in order to manage the severely septic patient and the associated multiple organ failure syndrome. Many of the principles applied to classic enterocutaneous fistulae are used as well. Control of enteric spillage, attempts to seal the fistula, and techniques of peritoneal access for excision of the involved loop are reviewed in this report. Additionally, we describe our recent proposal of a lateral surgical approach via the circumference of the open abdomen in order to avoid the hostile and granulated surface of the abdominal trauma, which is adhered to the intraperitoneal organs.
C1 [Marinis, A.] Tzaneion Gen Hosp, Dept Surg 1, GR-18536 Piraeus, Greece.
   [Gkiokas, G.; Fragulidis, G.; Polymeneas, G.; Voros, D.] Aretaieion Univ Hosp, Dept Surg 2, Athens, Greece.
   [Argyra, E.] Aretaieion Univ Hosp, Dept Anesthesiol 1, Athens, Greece.
RP Marinis, A (通讯作者)，Tzaneion Gen Hosp, Dept Surg 1, 1 Zanni & Afentouli STRs, GR-18536 Piraeus, Greece.
EM drmarinis@gmail.com
RI Gkiokas, Georgios/AAE-6312-2020
OI Fragulidis, Georgios/0000-0001-6011-8674; Marinis,
   Athanasios/0000-0001-6423-6651
CR Al-Khoury G, 2008, J AM COLL SURGEONS, V206, P397, DOI 10.1016/j.jamcollsurg.2007.07.027
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NR 30
TC 58
Z9 67
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD JUN
PY 2013
VL 102
IS 2
BP 61
EP 68
DI 10.1177/1457496913482252
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AG7FC
UT WOS:000335582700003
PM 23820678
DA 2026-07-24
ER
PT J
AU Asher, SA
   White, HN
   Golden, JB
   Magnuson, JS
   Carroll, WR
   Rosenthal, EL
AF Asher, Scott A.
   White, Hilliary N.
   Golden, Joseph B.
   Magnuson, J. Scott
   Carroll, William R.
   Rosenthal, Eben L.
TI Negative Pressure Wound Therapy in Head and Neck Surgery
SO JAMA FACIAL PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ORGAN PRESERVATION THERAPY; SALVAGE TOTAL
   LARYNGECTOMY; SOFT-TISSUE; PHARYNGOCUTANEOUS FISTULA; VASCULAR-SURGERY;
   MUSCLE FLAP; RECONSTRUCTION; MANAGEMENT; COMPLICATIONS
AB IMPORTANCE Negative pressure wound therapy has been shown to accelerate healing. There is a paucity of literature reporting its use as a tool to promote wound healing in head and neck reconstruction.
   OBJECTIVE To review 1 institution's experience with negative pressure dressings to further describe the indications, safety, and efficacy of this technique in the head and neck.
   DESIGN, SETTING, AND PARTICIPANTS Retrospective case series at a tertiary care academic hospital. One hundred fifteen patients had negative pressure dressings applied between April 2005 and December 2011. Data were gathered, including indications, details of negative pressure dressing use, adverse events, wound healing results, potential risk factors for compromised wound healing (defined as previous radiation therapy, hypothyroidism, or diabetes mellitus), and wound characteristics (complex wounds included those with salivary contamination, bone exposure, great vessel exposure, in the field of previous microvascular free tissue transfer, or in the case of peristomal application in laryngectomy).
   EXPOSURE Negative pressure wound therapy utilized after head and neck reconstruction.
   MAIN OUTCOMES AND MEASURES Indications for therapy, length and number of dressing applications, identification of wound healing risk factors, classification of wound complexity, wound healing results, and adverse events related to the use of the device.
   RESULTS Negative pressure wound therapy was used primarily for wounds of the neck (94 of 115 patients [81.7%]) in addition to other head and neck locations (14 of 115 patients [12.2%]), and free tissue transfer donor sites (7 of 115 patients [6.1%]). The mean (SD) wound size was 5.6 (5.0) cm. The mean number of negative pressure dressing applications was 1.7 (1.2), with an application length of 3.7 (1.4) days. Potential risk factors for compromised wound healing were present in 82 of 115 patients (71.3%). Ninety-one of 115 patients (79.1%) had complex wounds. Negative pressure dressings were used in wounds with salivary contamination (n = 64), bone exposure (n = 40), great vessel exposure (n = 25), previous free tissue transfer (n = 55), and peristomal application after laryngectomy (n = 32). Adverse events occurred in 4 of 115 patients (3.5%).
   CONCLUSIONS AND RELEVANCE Negative pressure wound therapy in head and neck surgery is safe and has potential to be a useful tool for complex wounds in patients with a compromised ability to heal.
C1 [Asher, Scott A.; White, Hilliary N.; Golden, Joseph B.; Magnuson, J. Scott; Carroll, William R.; Rosenthal, Eben L.] Univ Alabama Birmingham, Sch Med, Div Otolaryngol Head & Neck Surg, Dept Surg, Birmingham, AL USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Rosenthal, EL (通讯作者)，Div Otolaryngol Head & Neck Surg, BDB Suite 56,1808 Seventh Ave South, Birmingham, AL 35233 USA.
EM oto@uab.edu
RI Rosenthal, Eben/KLC-3513-2024; Magnuson, Jason/ABX-9283-2022
OI Rosenthal, Eben/0000-0003-0294-5203; 
CR Anagnostakos K., 2005, THEORY PRACTICE VACU
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NR 56
TC 21
Z9 24
U1 0
U2 8
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6076
EI 2168-6092
J9 JAMA FACIAL PLAST SU
JI JAMA Facial Plast. Surg.
PD MAR-APR
PY 2014
VL 16
IS 2
BP 120
EP 126
DI 10.1001/jamafacial.2013.2163
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AH2OX
UT WOS:000335961900008
PM 24357046
DA 2026-07-24
ER
PT J
AU Pitt, KA
   Stanley, BJ
AF Pitt, Kathryn A.
   Stanley, Bryden J.
TI Negative Pressure Wound Therapy: Experience in 45 Dogs
SO VETERINARY SURGERY
LA English
DT Article
DE wound dressing; negative pressure; vacuum-assisted; wound healing
ID VACUUM-ASSISTED-CLOSURE; LOWER-EXTREMITY TRAUMA; SECURING SKIN-GRAFTS;
   OPEN CELL FOAM; OPERATION IRAQI-FREEDOM; SUBATMOSPHERIC PRESSURE;
   POLYURETHANE-FOAM; SWINE MODEL; WAR WOUNDS; MANAGEMENT
AB ObjectiveTo report experience with negative pressure wound therapy (NPWT) in 45 consecutive dogs admitted with extensive cutaneous wounds and to determine if NPWT is feasible in veterinary hospital practice.
   Study DesignProspective descriptive study.
   AnimalsDogs (n=45).
   MethodsCollected data were organized into 6 categories: patient data, wound data, NPWT data, adjunctive treatments, complications, and final outcome.
   ResultsWounds (53 in 45 dogs) were largely traumatic in origin, and distributed fairly evenly to the trunk, proximal and distal aspects of the limbs. Most wounds (34 dogs, 76%) had no granulation tissue and were treated a mean of 4.2 days after wounding, whereas 11 dogs had granulating wounds that were initially treated a mean of 87 days after wounding. Median NPWT use was 3 days with a mean hospitalization of 7.8 days. Most wounds (33; 62%) were closed surgically after NPWT and were healed by 14 days. The other 18 wounds healed (mean, 21 days) by second intention after hospital discharge. Overall, 96% of the wounds healed; 2 dogs died before definitive closure could be attempted.
   ConclusionNPWT is applicable to a wide variety of canine wounds, is well tolerated, allows for several days between dressing changes, and can used to optimize the wound bed for surgical closure or second intention healing.
C1 [Pitt, Kathryn A.; Stanley, Bryden J.] Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
C3 Michigan State University
RP Stanley, BJ (通讯作者)，Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
EM stanle32@cvm.msu.edu
FU NIH HHS [T32 OD011167] Funding Source: Medline
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NR 64
TC 33
Z9 40
U1 0
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD MAY
PY 2014
VL 43
IS 4
BP 380
EP 387
DI 10.1111/j.1532-950X.2014.12155.x
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA AH2TA
UT WOS:000335972800002
PM 24512302
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Fleck, T
   Fleck, M
AF Fleck, Tatjana
   Fleck, Michael
TI Negative pressure wound therapy for the treatment of sternal wound
   infections after cardiac surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Postoperative complication; Sternal
   wound infection; Wound healing
ID VACUUM-ASSISTED CLOSURE; MEDIASTINITIS
AB We retrospectively collected and analysed data from patients with sternal wound infections between 1995 and 2001, which were treated with different wound management strategies, and compared them with our patients from 2002 to 2011, who were treated with the sternal negative pressure wound therapy (NPWT). From 1995 to 2001, a total of 198 patients (group A) with a mean age of 65 +/- 10 years developed sternal wound infection (67% deep) after cardiac surgery. Wound management consisted of surgical debridement and immediate sternal closure or open packing. From 2002 to 2011, a total of 326 patients (group B) (71% deep) were managed with NPWT at the time of surgical debridement. Total mortality was 10% in group A and 3.6% in group B. Recurrence rates were 34 and 8.5%, respectively, for the groups A and B. The meantime of NPWT was 11 days. In group B patients, 75% proceeded to sternal closure. With the introduction of NPWT, the treatment of sternal wound infections could be substantially improved. Particularly, the high recurrence rates could be minimised; furthermore, the goal to salvage the sternal bone is facilitated.
C1 [Fleck, Tatjana] Med Univ Vienna, Dept Cardiac Surg, AKH Vienna, A-1090 Vienna, Austria.
   [Fleck, Michael] Med Univ Vienna, Dept Cardiothorac & Vasc Anesthesia, AKH Vienna, A-1090 Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna
RP Fleck, T (通讯作者)，Med Univ Vienna, Dept Cardiac Surg, AKH Vienna, Leitstelle 20A,Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM tatjana.fleck@meduniwien.ac.at
FU KCI USA
FX This study was funded by KCI USA. The first author (TF) is a Consultant
   for KCI Int and KCI Europe.
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NR 23
TC 14
Z9 18
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
IS 3
BP 240
EP 245
DI 10.1111/j.1742-481X.2012.01079.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AH8HJ
UT WOS:000336377600003
PM 22943741
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Lelong, AS
   Martelli, N
   Bonan, B
   Prognon, P
   Pineau, J
AF Lelong, Anne-Sophie
   Martelli, Nicolas
   Bonan, Brigitte
   Prognon, Patrice
   Pineau, Judith
TI Use of a risk assessment method to improve the safety of negative
   pressure wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Risk analysis; Safety
ID MANAGEMENT; TISSUE
AB To conduct a risk analysis of the negative pressure wound therapy (NPWT) care process and to improve the safety of NPWT, a working group of nurses, hospital pharmacists, physicians and hospital managers performed a risk analysis for the process of NPWT care. The failure modes, effects and criticality analysis (FMECA) method was used for this analysis. Failure modes and their consequences were defined and classified as a function of their criticality to identify priority actions for improvement. By contrast to classical FMECA, the criticality index (CI) of each consequence was calculated by multiplying occurrence, severity and detection scores. We identified 13 failure modes, leading to 20 different consequences. The CI of consequences was initially 712, falling to 357 after corrective measures were implemented. The major improvements proposed included the establishment of 6-monthly training cycles for nurses, physicians and surgeons and the introduction of computerised prescription for NPWT. The FMECA method also made it possible to prioritise actions as a function of the criticality ranking of consequences and was easily understood and used by the working group. This study is, to our knowledge, the first to use the FMECA method to improve the safety of NPWT.
C1 [Lelong, Anne-Sophie; Martelli, Nicolas; Prognon, Patrice; Pineau, Judith] Georges Pompidou European Hosp, AP HP, Dept Pharm, F-75015 Paris, France.
   [Bonan, Brigitte] Foch Hosp, Dept Pharm, Suresnes, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Europeen Georges-Pompidou - APHP; Hospital Foch
RP Martelli, N (通讯作者)，Georges Pompidou European Hosp, AP HP, Dept Pharm, 20 Rue Leblanc, F-75015 Paris, France.
EM nicolas.martelli@egp.aphp.fr
RI Martelli, Nicolas/ABB-2722-2021
OI Martelli, Nicolas/0000-0001-5959-231X
CR Ahmed F, 2010, J PLAST RECONSTR AES, V63, pE497, DOI 10.1016/j.bjps.2009.09.006
   Anesäter E, 2011, INT WOUND J, V8, P336, DOI 10.1111/j.1742-481X.2011.00790.x
   Bonan B, 2009, INT J QUAL HEALTH C, V21, P44, DOI 10.1093/intqhc/mzn052
   Bonnabry P, 2006, INT J QUAL HEALTH C, V18, P9, DOI 10.1093/intqhc/mzi082
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   Bonnabry P, 2008, J AM MED INFORM ASSN, V15, P453, DOI 10.1197/jamia.M2677
   Citak M, 2010, ARCH ORTHOP TRAUM SU, V130, P1511, DOI 10.1007/s00402-010-1091-6
   *EWMA, 2007, POS DOC TOP NEG PRES
   Fraccalvieri M, 2011, INT WOUND J, V8, P355, DOI 10.1111/j.1742-481X.2011.00798.x
   French National Authority for Health, 2010, NEG PRESS WOUND THER
   Kamolz LP, 2004, BURNS, V30, P253, DOI 10.1016/j.burns.2003.12.003
   KCI, 2010, VAC THER CLIN GUID R
   Lepage B, 2009, QUAL SAF HEALTH CARE, V18, P441, DOI 10.1136/qshc.2007.025742
   Nguyen C, 2011, J EVAL CLIN PRACT
   Niel-Lainé J, 2011, BMJ QUAL SAF, V20, P698, DOI 10.1136/bmjqs.2010.048074
   Orgill DP, 2011, PLAST RECONSTR SURG, V127, p105S, DOI 10.1097/PRS.0b013e318200a427
   Smith & Nephew, 2011, SMITH NEPHEW RENASYS
   U.S. Food and Drug Administration, 2009, FDA PREL PUBL HLTH N
   US Food and Drug Administration. Center for Devices and Radiological Health, 2009, ADV PAT SER COMPL NE
   van Wingerden JJ, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-121
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 21
TC 1
Z9 2
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
IS 3
BP 253
EP 258
DI 10.1111/j.1742-481X.2012.01081.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AH8HJ
UT WOS:000336377600005
PM 22931525
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Nickerson, TP
   Zielinski, MD
   Jenkins, DH
   Schiller, HJ
AF Nickerson, Terry P.
   Zielinski, Martin D.
   Jenkins, Donald H.
   Schiller, Henry J.
TI The Mayo Clinic experience with Morel-Lavallee lesions: Establishment of
   a practice management guideline
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Closed degloving injury; Morel-Lavallee lesion; posttraumatic seroma
ID CLOSED DEGLOVING INJURIES; THIGH; SCLERODHESIS; EFFUSIONS
AB BACKGROUND: Although uncommon, Morel-Lavallee lesions (also called closed degloving injuries) are associated with considerable morbidity in trauma patients. There is lack of consensus regarding proper management of these lesions. Management options include nonoperative therapies, along with percutaneous and operative techniques. We sought to define the factors associated with failure of percutaneous aspiration to better identify patients requiring immediate operative management.
   METHODS: We retrospectively searched our prospectively collected database for patient records containing the terms Morel-Lavallee, closed degloving injury, or posttraumatic seroma from February 2, 2004, through December 23, 2011. Treatment methods included compression wraps or observation (nonoperative management), percutaneous aspiration, or operative management with incision/drainage or formal debridement of skin and soft tissues that resulted in wound vacuum-assisted closure placement and/or split-thickness skin graft (operative management). The treatment groups were compared using univariate analysis and chi(2) testing.
   RESULTS: We identified 79 patients with 87 Morel-Lavallee lesions in the setting of trauma. Most were caused by motor vehicle collisions (25%). No difference was observed between the treatment groups in sex, body mass index, anticoagulation treatment, diabetes mellitus, smoking history, or alcohol use. The percutaneous aspiration group had higher rates of recurrence (56% vs. 19% and 15% in nonoperative and operative groups, respectively). The percentage of patients who had aspiration of more than 50 mL of fluid was higher for lesions that recurred than for lesions that resolved (83% vs. 33%, p = 0.02).
   CONCLUSION: Aspiration of more than 50 mL of fluid from Morel-Lavallee lesions was much more common among lesions that recurred (83%) than among those that resolved (33%). We therefore recommend that aspiration of more than 50 mL of fluid from a Morel-Lavallee lesion prompts operative intervention. We have now adopted this as a practice management guideline. Copyright (C) 2014 by Lippincott Williams & Wilkins
C1 [Nickerson, Terry P.; Zielinski, Martin D.; Jenkins, Donald H.; Schiller, Henry J.] Mayo Clin, Div Trauma Crit Care & Gen Surg, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Schiller, HJ (通讯作者)，Mayo Clin, Div Trauma Crit Care & Gen Surg, 200 First St SW, Rochester, MN 55905 USA.
EM schiller.henry@mayo.edu
CR Bansal A, 2013, INJURY, V44, P66, DOI 10.1016/j.injury.2011.11.024
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NR 18
TC 112
Z9 153
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD FEB
PY 2014
VL 76
IS 2
BP 493
EP 497
DI 10.1097/TA.0000000000000111
PG 5
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA AH8KG
UT WOS:000336386100036
PM 24458056
DA 2026-07-24
ER
PT J
AU Tian, B
   Khoo, D
   Tay, AC
   Soo, KC
   Tan, NC
   Tan, HK
   Iyer, NG
AF Tian, Brian
   Khoo, Deborah
   Tay, Ai Choo
   Soo, Khee-Chee
   Tan, Ngian Chye
   Tan, Hiang Khoon
   Iyer, N. Gopalakrishna
TI Management of orocutaneous fistulas using a vacuum-assisted closure
   system
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Article
DE salivary fistula; pharyngocutaneous fistula; anastomotic leak;
   postoperative complications; vacuum-assisted closure
ID PHARYNGOCUTANEOUS FISTULA; WOUND CONTROL; NECK WOUNDS; THERAPY; SOFT;
   STABILITY; STRESS; HEAD
AB BackgroundThe vacuum-assisted closure (VAC) system has been used to manage complicated wounds. The purpose of this study was to describe a novel technique in using the VAC system for orocutaneous fistulas.
   MethodsA retrospective study was performed on 10 patients treated at the National Cancer Centre, Singapore, who developed postoperative orocutaneous fistulas. Hydrogum dental paste was used as a sealant together with the VAC system to close the fistulas. We used either the RENASYS or VAC ATS system with 50 mm Hg to 125 mm Hg continuous suction.
   ResultsThe 10 patients developed 11 fistulas. The median age of this cohort was 67 years (range, 33-80 years). Nine patients had successful closure of their fistulas with VAC therapy whereas 1 patient had unsuccessful VAC therapy and required flap reconstruction. The median time to fistula closure was 19 days (range, 6-36 days). The median time to radiotherapy after surgery was 46 days (range, 26-62 days).
   ConclusionVAC therapy is an effective treatment option for orocutaneous fistulas. (c) 2013 Wiley Periodicals, Inc. Head Neck 36: 873-881, 2014
C1 [Tian, Brian; Khoo, Deborah; Soo, Khee-Chee; Tan, Ngian Chye; Tan, Hiang Khoon; Iyer, N. Gopalakrishna] Natl Canc Ctr Singapore, Dept Surg Oncol, Singapore 169610, Singapore.
   [Tay, Ai Choo] Singapore Gen Hosp, Dept Nursing, Singapore, Singapore.
C3 National Cancer Centre Singapore (NCCS); Singapore General Hospital
RP Iyer, NG (通讯作者)，Natl Canc Ctr Singapore, 11 Hosp Dr, Singapore 169610, Singapore.
EM gopaliyer@yahoo.com
RI Tan, Hiang Khoon/AAG-2815-2021
OI Tan, Hiang Khoon/0000-0002-8565-2926; Iyer, N.
   Gopalakrishna/0000-0002-8812-6219; Khoo, Deborah/0000-0001-7961-5339
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NR 22
TC 25
Z9 28
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD JUN
PY 2014
VL 36
IS 6
BP 873
EP 881
DI 10.1002/hed.23393
PG 9
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA AH9VP
UT WOS:000336493200021
PM 23733717
DA 2026-07-24
ER
PT J
AU Jeffers, AM
   Maxson, PM
   Thompson, SL
   McCormack, HE
   Cima, RR
AF Jeffers, Amy M.
   Maxson, Pamela M.
   Thompson, Susan L.
   McCormack, Heather E.
   Cima, Robert R.
TI Combined Negative Pressure Wound Therapy and Ultrasonic MIST Therapy for
   Open Surgical Wounds A Case Series
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE negative pressure wound therapy; noncontact low-frequency ultrasound;
   open abdominal wounds; secondary-intention wound healing; surgical
   wounds; ultrasonic MIST therapy
ID VACUUM-ASSISTED CLOSURE; LOW-FREQUENCY ULTRASOUND; NONCONTACT
AB BACKGROUND: Surgical wounds are at increased risk of infection when left open to heal through secondary intention; they increase length of hospital stay, hospital costs, readmission rates, and patient morbidity. New technologies and methods of treating acute and chronic wounds are emerging. Two recent developments for the treatment of open wounds are noncontact low-frequency ultrasound (NCLFU) treatment and negative pressure wound therapy (NPWT).
   METHODS: This case series reports findings from 4 hospitalized patients with complex conditions who underwent colorectal surgery resulting in open abdominal wounds. The wounds were treated with NCLFU in combination with NPWT. Data were collected via retrospective review of medical records.
   RESULTS: After concurrent treatment with NPWT (range, 13-18 days) and NCLFU (range, 5-9 treatments), wound areas in these 4 cases were reduced by 4.5% to 37% and wound volume decreased by 17% to 62%. Granulation tissue increased in the open tissue areas in all patients. In addition, 3 of the cases received a mesh graft.
   CONCLUSIONS: Combination treatment with NPWT and NCLFU therapy with or without sharp debridement enhanced wound healing in the open abdominal wounds of these 4 patients.
C1 [Jeffers, Amy M.; Maxson, Pamela M.; Thompson, Susan L.] Mayo Clin, Dept Nursing, Rochester, MN 55905 USA.
   [McCormack, Heather E.] Mayo Clin, Dept Phys Med & Rehabil, Rochester, MN 55905 USA.
   [Cima, Robert R.] Mayo Clin, Div Colon & Rectal Surg, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Maxson, PM (通讯作者)，Mayo Clin, Dept Nursing, 200 First St SW, Rochester, MN 55905 USA.
EM maxson.pamela@mayo.edu
CR [Anonymous], 2012, ACUTE CHRONIC WOUNDS
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   de Lissovoy G, 2009, AM J INFECT CONTROL, V37, P387, DOI 10.1016/j.ajic.2008.12.010
   Kavros Steven J, 2007, Adv Skin Wound Care, V20, P221, DOI 10.1097/01.ASW.0000266660.88900.38
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   Liguori PA, 2008, OSTOMY WOUND MANAG, V54, P50
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Orgill DP, 2009, SURGERY, V146, P40, DOI 10.1016/j.surg.2009.02.002
   Serena T, 2009, OSTOMY WOUND MANAG, V55, P22
   Sussman C, 2007, WOUND CARE COLLABORA, P612
   Thai Thao P, 2002, Ostomy Wound Manage, V48, P52
   Wick EC, 2011, DIS COLON RECTUM, V54, P1475, DOI 10.1097/DCR.0b013e31822ff8f0
NR 14
TC 5
Z9 5
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAR-APR
PY 2014
VL 41
IS 2
BP 181
EP 186
DI 10.1097/WON.0000000000000014
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AH9WV
UT WOS:000336496700011
PM 24595182
DA 2026-07-24
ER
PT J
AU Argo, R
AF Argo, Rosie
TI Necrotizing Enterocolitis in a Neonate A Case Study Using Negative
   Pressure Wound Therapy
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE abdominal wall defects; negative pressure wound therapy neonates;
   negative pressure wound therapy; neonate necrotizing enterocolitis
ID MANAGEMENT
AB BACKGROUND: Necrotizing enterocolitis (NEC) is a disease of the intestine detrimental that occurs in approximately 10% of neonates who weigh 1500 g or less; it is associated with a 25% mortality rate. Additional abdominal wall defects and disturbance of environmental surroundings further compromise the likelihood of mortality. Early intervention and aggressive surgical treatment have been shown to decrease the mortality rate of this disease process.
   CASE STUDY: This case study describes wound and ostomy management on a neonate with NEC who, after bowel perforation, required a distal and proximal jejunostomy and a colostomy. Frequent dressing changes were disrupting the neonates' environmental factors that affect growth. Management began with an alginate dressing, but it was unsuccessful in containing the drainage. Negative pressure wound therapy was then applied to eliminate exudate and infectious material, control odor, and decrease environmental factors affecting growth, as well as to assist in wound closure.
   CONCLUSION: Necrotizing enterocolitis and potential complications such as perforation and dehiscence can be devastating for hospitalized neonates. In this case, negative pressure wound therapy promoted tissue growth and managed exudate and odor, while decreasing intervals between dressing changes. The abdominal wound healed, allowing for a better plane for stoma pouching. The neonate's ostomies were successfully reversed and he continues to thrive to date.
C1 Banner Estrella Med Ctr, Phoenix, AZ 85037 USA.
C3 Banner Research; Banner Health; Banner Estrella Medical Center
RP Argo, R (通讯作者)，Banner Estrella Med Ctr, 9201 West Thomas Rd, Phoenix, AZ 85037 USA.
EM Rosie.argo@bannerhealth.com
CR Altimier L, 2003, COMPREHENSIVE NEONAT, p[229, 20]
   Borgquist O, 2011, OSTOMY WOUND MANAG, V57, P44
   Bryant PA, 2004, NAT REV IMMUNOL, V4, P457, DOI 10.1038/nri1369
   de Leon JM, 2013, J WOUND OSTOMY CONT, V40, P481, DOI 10.1097/WON.0b013e3182a21c08
   Razmus IS, 2011, J WOUND OSTOMY CONT, V38, P22, DOI [10.1097/WON.0b013e318202abdd, 10.1097/WON.0b013e3181fee6e9]
NR 5
TC 2
Z9 3
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2014
VL 41
IS 3
BP 222
EP 225
DI 10.1097/WON.0000000000000033
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AH9ZN
UT WOS:000336505400006
PM 24805173
DA 2026-07-24
ER
PT J
AU Guffanti, A
AF Guffanti, Alan
TI Negative Pressure Wound Therapy in the Treatment of Diabetic Foot Ulcers
   A Systematic Review of the Literature
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE diabetic wounds; negative pressure wound therapy; standard moist wound
   therapy; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; MULTICENTER
AB Negative pressure wound therapy (NPWT) is an option for management of complex wounds such as diabetic foot ulcers; therefore, the nursing literature from 2000 to 2010 was reviewed for studies comparing clinical outcomes for diabetic foot ulcers treated with NPWT and those treated with standard moist wound therapy (SMWT). PubMed and OVID databases were explored using the following search terms: vacuum-assisted closure, NPWT, diabetic wounds, and standard most wound therapy. Research studies to judge efficacy were limited to the results from studies of experimental studies with randomized clinical trials on patients with diabetic foot wounds as the inclusion criteria. Four studies were identified that met the established criteria. Despite variations in patient population, methodology, and additional outcome variables studied, NPWT systems were shown to be more effective than SMWT with regard to proportion of healed wounds and rate of wound closure.
C1 [Guffanti, Alan] Adv Vasc Wound Associates, Darby, PA USA.
RP Guffanti, A (通讯作者)，101 Summit Lane,Apt E1, Bala Cynwyd, PA 19004 USA.
EM alan.guffanti@gmail.com
CR [Anonymous], DIAB STAT
   [Anonymous], 2011 NAT DIAB FACT S
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
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NR 13
TC 28
Z9 37
U1 4
U2 43
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2014
VL 41
IS 3
BP 233
EP 237
DI 10.1097/WON.0000000000000021
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AH9ZN
UT WOS:000336505400008
PM 24805174
DA 2026-07-24
ER
PT J
AU Téot, L
   Guillot-Masanovic, M
   Miquel, P
   Truchetet, F
   Meaume, S
   Dompmartin, A
   Kerihuel, JC
   Trial, C
   Faure, C
AF Teot, Luc
   Guillot-Masanovic, Margot
   Miquel, Pierre
   Truchetet, Francois
   Meaume, Sylvie
   Dompmartin, Anne
   Kerihuel, Jean Charles
   Trial, Chloe
   Faure, Christine
TI Clinical impact of negative-pressure wound therapy: A 1,126-patient
   observational prospective study
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; END-POINTS;
   MULTICENTER; ULCER; EXPERIENCE
AB Negative-pressure wound therapy (NPWT) was developed in the early 1990s and reported in 1997 by Argenta and Morykwas. Ignored at first, this technique progressively came to be considered as an outstanding advancement in reconstructive surgery. Several randomized controlled studies produced evidence for the effect of NPWT on promotion of granulation tissue formation and prevention of tissue damage and amputation. However, no important longitudinal study has yet produced clinical and economic data on the consequences of integrating NPWT into practice in multiple institutions. This prospective, comparative longitudinal study of NPWT as a clinical-practice innovation was conducted in 1,126 patients between March 2006 and June 2009 in 30 university and nonuniversity public and private hospitals in France. NPWT was proposed in a nonrandomized fashion for various clinical indications, and the patients were divided into two groups, one using NPWT, the second using standard care. Efficacy criteria were spontaneous closure, closure after surgical coverage using skin grafts or flaps, or achievement of 40% wound area regression. The results, observed in a pragmatic but not randomized study, are suggestive of a favorable impact of NPWT in multiple clinical situations. The significance of differences between surgical patients who underwent NPWT and those who did not was unclear, as NPWT had already been adopted by most of the surgical wards.
C1 [Teot, Luc; Trial, Chloe] Montpellier Reg Univ Hosp, Dept Surg, Montpellier, France.
   [Guillot-Masanovic, Margot] La Reunion Reg Univ Hosp, Rehabil Unit, St Denis, Reunion, France.
   [Miquel, Pierre] Valenciennes Hosp, Dept Orthoped, Valenciennes, France.
   [Truchetet, Francois] Metz Thionville Reg Univ Hosp, Dept Dermatol, Thionville, France.
   [Meaume, Sylvie] Paris Rothschild APHP Univ Hosp, Dept Geriatr, Paris, France.
   [Dompmartin, Anne] Caen Reg Univ Hosp, Dept Dermatol, Caen, France.
   [Kerihuel, Jean Charles] Vertical Co, Paris, France.
   [Faure, Christine] Montpellier Reg Univ Hosp, Montpellier, France.
C3 Universite de Montpellier; CHU de Montpellier; CHU Reunion; CH de
   Valenciennes; CHR Metz-Thionville; Assistance Publique Hopitaux Paris
   (APHP); Sorbonne Universite; Hopital Universitaire Rothschild - APHP;
   CHU de Caen NORMANDIE; Universite de Montpellier; CHU de Montpellier
RP Téot, L (通讯作者)，Hop Lapeyronie, Montpellier Univ Hosp, Dept Surg, Wound Healing Unit, 371 Ave Doyen Giraud, F-34295 Montpellier 5, France.
EM l-teot@chu-montpellier.fr
RI Dompmartin, Anne/HNI-8166-2023
FU French Ministry of Health; Direction Generale de l'Offre de Soins under
   French Ministry of Health
FX The STIC-TPN study group was funded by the French Ministry of Health and
   mainly realized thanks to the participation of Alain-Charles Masquelet
   (AP-HP Avicenne), Beatrice Crickx (AP-HP Bichat), Clelia Debure (AP-HP
   HEGP-Broussais), Maurice Mimoun and Florent Bonnet (AP-HP Rothschild),
   Patrice Mertl and Catherine Lok (CHU Amiens), Sandrine Cairey-Remonnay
   and Brigitte Faivre (CHU Besancon), Jean-Claude Castede and Thierry
   Fabre (CHU Bordeaux), Fabrice Narducci (Centre Oscar Lambret Lille),
   Bernard Lelong (Institut Paoli Calmettes Marseille), Michel Pannier and
   Franck Duteille (CHU Nantes), Elisa Lebreton (CHU Nice), Jean-Louis
   Richard and Denyse Vannereau (CHU Nimes), Geraldine Perceau (CHU Reims),
   Astrid Wilk (CHU Strasbourg), Jean-Louis Grolleau (CHU Toulouse), and
   Matthieu Lebrun and Annie Vermersch (CH Valenciennes).r A special thanks
   to Sophie Pinson, CRA, and to Cecile Peignier, project nurse in the
   Montpellier University Hospital. This study was covered by a project
   grant from the Direction Generale de l'Offre de Soins under the French
   Ministry of Health.
CR [Anonymous], 2004, WOUNDS, p3S
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
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   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Bovill E, 2008, INT WOUND J, V5, P511, DOI 10.1111/j.1742-481X.2008.00437.x
   DeFranzo AJ, 2008, PLAST RECONSTR SURG, V121, P832, DOI 10.1097/01.prs.0000299268.51008.47
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   Fuchs U, 2005, ANN THORAC SURG, V79, P526, DOI 10.1016/j.athoracsur.2004.08.032
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Moues C M, 2005, J Wound Care, V14, P224
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   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Steed DL, 2003, SURG CLIN N AM, V83, P547, DOI 10.1016/S0039-6109(02)00208-6
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NR 21
TC 9
Z9 12
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2014
VL 22
IS 3
BP 341
EP 350
DI 10.1111/wrr.12179
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA AI1QF
UT WOS:000336625600008
PM 24844333
DA 2026-07-24
ER
PT J
AU Kairinos, N
   McKune, A
   Solomons, M
   Hudson, DA
   Kahn, D
AF Kairinos, Nicolas
   McKune, Andrew
   Solomons, Michael
   Hudson, Donald A.
   Kahn, Delawir
TI The flaws of laser Doppler in negative-pressure wound therapy research
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; MICROVASCULAR
   BLOOD-FLOW; ACTIVATION; RESPONSES
AB Recent studies, using modalities other than laser Doppler, have indicated that perfusion during negative-pressure wound therapy (NPWT) is reduced, contrary to world literature. The aim of the present study was to evaluate whether the measuring technique of the laser Doppler could be influenced by the compressive nature of NPWT dressings and whether this could explain the conflicting findings. A hypothesis that it may be possible for laser Doppler to record similar readings to those obtained during NPWT by merely compressing tissues manually was tested on 12 NPWT dressings, with each undergoing an alternating series of manual compressive forces and NPWT (-125mmHg). During the periods of NPWT (n=12), the mean perfusion recording increased in five experiments, reduced in six, and remained unchanged in one. During the period when manual pressure was applied (n=12), there was a mean increase in perfusion in six experiments and a reduction in six. The type of change in perfusion (increase or decrease) was the same for both NPWT and manual pressure in 10 of the 12 experiments. In conclusion, laser Doppler can incorrectly record increased perfusion when tissues are compressed, implying that it is flawed in the field of NPWT research as tissues are always compressed to some degree by the NPWT dressing.
C1 [Kairinos, Nicolas; Hudson, Donald A.] Univ Cape Town, Dept Plast Reconstruct & Maxillofacial Surg, ZA-7925 Cape Town, South Africa.
   [Kairinos, Nicolas; Hudson, Donald A.; Kahn, Delawir] Groote Schuur Hosp, ZA-7925 Cape Town, South Africa.
   [McKune, Andrew] Univ KwaZulu Natal, Dept Sports Sci, Durban, South Africa.
   [Solomons, Michael] Univ Cape Town, Dept Orthopaed Surg, Martin Singer Hand Unit, ZA-7925 Cape Town, South Africa.
   [Kahn, Delawir] Univ Cape Town, Dept Surg, ZA-7925 Cape Town, South Africa.
C3 University of Cape Town; University of Cape Town; University of Kwazulu
   Natal; University of Cape Town; University of Cape Town
RP Kairinos, N (通讯作者)，5 Pipit Lane,Century Dr, ZA-7441 Cape Town, South Africa.
EM nickykairinos@gmail.com
RI McKune, Andrew/AAM-3086-2020
OI McKune, Andrew/0000-0002-5479-1544
FU Department of Surgery, Groote Schuur Hospital; University of Cape Town
FX This study was supported by funding from the Department of Surgery,
   Groote Schuur Hospital and the University of Cape Town. We would like to
   acknowledge Professor Sandie Thomson and Dr. Damian Clark for granting
   us the use of their laser Doppler.
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   Willy C, 2006, ZBL CHIR, V131, pS50, DOI 10.1055/s-2006-921421
NR 30
TC 26
Z9 30
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2014
VL 22
IS 3
BP 424
EP 429
DI 10.1111/wrr.12168
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA AI1QF
UT WOS:000336625600017
PM 24844341
DA 2026-07-24
ER
PT J
AU Abarca-Buis, RF
   Munguía, NM
   Gonzalez, JMM
   Solís-Arrieta, L
   Osorio, LSY
   Krötzsch, E
AF Abarca-Buis, Rene F.
   Munguia, Nadia M.
   Melchor Gonzalez, Juan Manuel
   Solis-Arrieta, Lilia
   Saldivar y Osorio, Liliana
   Kroetzsch, Edgar
TI Silver from Polyurethane Dressing Is Delivered by Gradient to Exudate,
   Tissue, and Serum of Patients Undergoing Negative-Pressure Wound
   Treatment
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative-pressure wound therapy; silver dressing; wounds
ID VACUUM-ASSISTED CLOSURE; TOPICAL SILVER; ARGYRIA; SULFADIAZINE;
   SELENIUM; METALLOTHIONEIN; MICROANALYSIS; BLOOD; LIGHT
AB OBJECTIVE: This study aimed to evaluate the distribution and concentration of silver eluted from silver-coated polyurethane dressing (V.A.C. GranuFoam Silver Dressing; KCI, San Antonio, Texas) in vitro and in patients undergoing negative-pressure wound therapy (NPWT).
   DESIGN: This was a descriptive study of the effect of silver-coated polyurethane dressing in patients undergoing NPWT.
   PARTICIPANTS: Six patients with infected wounds undergoing NPWT using silver-coated polyurethane dressing.
   INTERVENTIONS: To evaluate silver release in vitro, the authors soaked dressing fragments in water and human serum for different lengths of time and performed atomic absorption spectroscopy. For patient evaluation, the authors obtained exudate, serum, and wound tissue at different time points from 6 patients undergoing NPWT and measured silver levels by atomic absorption and dispersed x-ray spectroscopy.
   MAIN RESULTS: Silver from the dressing was immediately released in vitro at a rate 3 times greater in serum than in water. In vivo, silver was delivered to wound exudate at rates 102 to 104 times greater than in corresponding serum. Few surface silver deposits were detected in treated tissue.
   CONCLUSION: The high concentration of silver found in wound exudate reflects not only the affinity for silver in serum components and wound fluids, but also that most silver ions are not distributed systemically in the patient; instead, they are transported by the vacuum created by therapy.
C1 [Abarca-Buis, Rene F.; Kroetzsch, Edgar] Inst Nacl Rehabil, Ctr Nacl Invest & Atenc Quemados, Lab Connect Tissue, Mexico City, DF, Mexico.
   [Munguia, Nadia M.; Saldivar y Osorio, Liliana] Univ Nacl Autonoma Mexico, Fac Quim, Dept Analyt Chem, Mexico City 04510, DF, Mexico.
   [Melchor Gonzalez, Juan Manuel] Inst Seguridad Social Estado Mexico & Municipios, Dept Plast Surg, Mexico City, DF, Mexico.
   [Solis-Arrieta, Lilia] Inst Nacl Rehabil, Lab Elect Microscopy, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Abarca-Buis, RF (通讯作者)，Inst Nacl Rehabil, Ctr Nacl Invest & Atenc Quemados, Lab Connect Tissue, Mexico City, DF, Mexico.
RI Krötzsch, Edgar/ABG-2017-2021
OI Krötzsch, Edgar/0000-0002-0696-0147; Abarca-Buis, René
   Fernando/0000-0003-3372-813X
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NR 37
TC 11
Z9 11
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD APR
PY 2014
VL 27
IS 4
BP 156
EP 162
DI 10.1097/01.ASW.0000444849.71374.bc
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA AI2ZK
UT WOS:000336727500003
PM 24637649
DA 2026-07-24
ER
PT J
AU Cauthon, DJ
   Worthen, T
   Freed, L
   DeComas, AM
AF Cauthon, David J.
   Worthen, Tucker
   Freed, Lewis
   DeComas, Amalia M.
TI Malignant Eccrine Hidradenoma
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID CLEAR-CELL HIDRADENOMA; SKIN
AB Hidradenomas are adenomatous tumors of sweat gland origin that are usually benign and can occur in any cutaneous skin surface. When malignant, the tumors have high recurrence rates and are often fatal. Because of their infrequency and clinical ambiguity, hidradenomas are often misdiagnosed as other soft-tissue masses. Radiation and chemotherapy have not shown to be of benefit; therefore, wide aggressive excision and lymphadenectomy are currently the treatments of choice. We present the case of a patient with a malignant hidradenoma presenting in her medial heel. After excisional biopsy identified the tumor, the patient was successfully treated with wide excision and delayed closure via vacuum-assisted closure.
C1 [Cauthon, David J.; Worthen, Tucker] Midwestern Univ, Arizona Sch Podiatr Med, Glendale, AZ 85308 USA.
   [Freed, Lewis] East Valley Foot & Ankle Specialists, Mesa, AZ USA.
   [DeComas, Amalia M.] Core Inst, Phoenix, AZ USA.
C3 Midwestern University; Midwestern University - Glendale
RP Cauthon, DJ (通讯作者)，Midwestern Univ, Arizona Sch Podiatr Med, 19555 N 59th Ave, Glendale, AZ 85308 USA.
EM david.cauthon@gmail.com
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NR 17
TC 0
Z9 1
U1 0
U2 1
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD JUL-AUG
PY 2013
VL 103
IS 4
BP 333
EP 336
DI 10.7547/1030333
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA AI4PK
UT WOS:000336847100009
PM 23878386
DA 2026-07-24
ER
PT J
AU Driver, VR
   Blume, PA
AF Driver, Vickie R.
   Blume, Peter A.
TI Evaluation of Wound Care and Health-Care Use Costs in Patients with
   Diabetic Foot Ulcers Treated with Negative Pressure Wound Therapy versus
   Advanced Moist Wound Therapy
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; IMPACT
AB Background: We conducted a post-hoc retrospective analysis of patients enrolled in a randomized controlled trial to evaluate overall costs of negative pressure wound therapy (NPWT; V.A.C. Therapy; KCI USA, Inc, San Antonio, Texas) versus advanced moist wound therapy (AMWT) in treating grade 2 and 3 diabetic foot wounds during a 12-week therapy course.
   Methods: Data from two study arms (NPWT [n = 169] or AMWT [n = 166]) originating from Protocol VAC2001-08 were collected from patient records and used as the basis of the calculations performed in our cost analysis.
   Results: A total of 324 patient records (NPWT = 162; AMWT = 162) were analyzed. There was a median wound area reduction of 85.0% from baseline in patients treated with NPWT compared to a 61.8% reduction in those treated with AMWT. The total cost for all patients, regardless of closure, was $1,941,472.07 in the NPWT group compared to $2,196,315.86 in the AMWT group. In patients who achieved complete wound closure, the mean cost per patient in the NPWT group was $10,172 compared to $9,505 in the AMWT group; the median cost per 1 cm(2) of closure was $1,227 with NPWT and $1,695 with AMWT. In patients who did not achieve complete wound closure, the mean total wound care cost per patient in the NPWT group was $13,262, compared to $15,069 in the AMWT group. The median cost to close 1 cm2 in wounds that didn't heal using NPWT was $1,633, compared to $2,927 with AMWT.
   Conclusions: Our results show greater cost effectiveness with NPWT versus AMWT in recalcitrant wounds that didn't close during a 12-week period, due to lower expenditures on procedures and use of health-care resources.
C1 [Driver, Vickie R.] VA New England Hlth Care Div, Dept Surg, Providence, RI 02908 USA.
   [Blume, Peter A.] Yale Univ, Sch Med, Dept Anesthesiol, New Haven, CT 06510 USA.
C3 Yale University
RP Driver, VR (通讯作者)，VA New England Hlth Care Div, Dept Surg, 830 Chalkstone Ave, Providence, RI 02908 USA.
EM drvdriver@aol.com
CR [Anonymous], 3 C WORLD UN WOUND H
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NR 27
TC 43
Z9 46
U1 1
U2 25
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD MAR-APR
PY 2014
VL 104
IS 2
BP 147
EP 153
DI 10.7547/0003-0538-104.2.147
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA AI4QD
UT WOS:000336849000004
PM 24725034
DA 2026-07-24
ER
PT J
AU Lin, CY
   Li, TS
   Choong, MY
   Chung, KC
AF Lin, Chih-Yen
   Li, Tzong-Shiun
   Choong, Mun-Yau
   Chung, Kao-Chi
TI A Modified Negative Pressure Wound Therapy System for Curviform Skin
   Graft Wounds
SO AMERICAN SURGEON
LA English
DT Article
C1 [Lin, Chih-Yen; Chung, Kao-Chi] Natl Cheng Kung Univ, Inst Biomed Engn, Tainan 70101, Taiwan.
   [Li, Tzong-Shiun; Choong, Mun-Yau] China Med Univ, Div Plast Surg, Dept Surg, China Med Univ Hosp, Taichung, Taiwan.
C3 National Cheng Kung University; China Medical University Taiwan; China
   Medical University Hospital - Taiwan
RP Chung, KC (通讯作者)，Natl Cheng Kung Univ, Inst Biomed Engn, 701 1 Univ Rd, Tainan 70101, Taiwan.
EM kaochi@mail.bme.ncku.edu.tw
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Molnar JA, 2000, PLAST RECONSTR SURG, V105, P174, DOI 10.1097/00006534-200001000-00030
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
NR 4
TC 0
Z9 0
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JAN
PY 2013
VL 79
IS 1
BP E52
EP E53
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AI6DT
UT WOS:000336961200021
PM 23317611
DA 2026-07-24
ER
PT J
AU Batra, RK
   Aseeja, V
AF Batra, R. K.
   Aseeja, Veena
TI VAC Therapy in Large Infected Sacral Pressure Ulcer Grade IV-Can Be an
   Alternative to Flap Reconstruction?
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Vacuum-assisted closure (VAC) therapy; Flap surgery
AB Vacuum-assisted closure (VAC) therapy is a new entrant in wound care after growth factors and alginate or hydrocolloid dressing, in the treatment of pressure ulcers. We have been using this technique for diabetic foot ulcers. A young nondiabetic man presented with a large sacral bed sore after high doses of ionotropes in an intensive care unit for treating severe hypotension. His wound was debrided, and instead of flap surgery in such infected wound, he was treated with VAC therapy. The complete wound healing was achieved in 6 weeks and at half the cost of flap surgery. Moreover, the chances of flap failure and its related complications were eliminated.
C1 [Batra, R. K.] Alchemist Hosp, Sect 21, Panchkula, Haryana, India.
   [Aseeja, Veena] MMIMSR, Mullana, Haryana, India.
C3 Maharishi Markandeshwar University
RP Batra, RK (通讯作者)，Alchemist Hosp, Sect 21, Panchkula, Haryana, India.
EM rkbatra70@rediffmail.com
CR Bassetto F, 2012, J PLAST RECONSTR AES, V65, P91, DOI 10.1016/j.bjps.2011.08.016
   Baynham S., 1999, OSTOMY WOUND MANAGE, V45, P34
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   PHILBECK TE, 2001, HOME CARE CONSULTANT, V8, P27
   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
NR 7
TC 7
Z9 10
U1 0
U2 11
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD APR
PY 2014
VL 76
IS 2
BP 162
EP 164
DI 10.1007/s12262-012-0770-7
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AI6KD
UT WOS:000336981800019
PM 24891788
OA Bronze
DA 2026-07-24
ER
PT J
AU Shada, AL
   Rosenberger, LH
   Mentrikoski, MJ
   Silva, MA
   Feldman, SH
   Kleiner, DE
AF Shada, Amber L.
   Rosenberger, Laura H.
   Mentrikoski, Mark J.
   Silva, Michael A.
   Feldman, Sanford H.
   Kleiner, Daniel E.
TI Endoluminal Negative-Pressure Therapy for Preventing Rectal Anastomotic
   Leaks: A Pilot Study in a Pig Model
SO SURGICAL INFECTIONS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COLORECTAL SURGERY; ANTERIOR RESECTION; STOMA
AB Background: Anastomotic leak after rectal resection carries substantial morbidity and mortality. A diverting ileostomy is beneficial for high-risk anastomoses, but its creation and reversal carry a surgical risk in addition to that of resection itself. We sought an alternative method for managing complications of rectal anastomosis.
   Methods: We developed an endoluminal negative-pressure technology with a diverting proximal sump, and hypothesized that it would close anastomotic disruptions in pigs. We performed rectal resections on pigs, with primary anastomoses and the creation of an anastomotic defect. In animals in the treatment group we inserted an endoluminal negative-pressure device and kept it at a low level of continuous suction for 5 d. No device was inserted in a control group of animals. After the 5-d period of treatment we evaluated the anastomoses in both the treatment and control groups of animals for leakage, using contrast enemas. Specimens of anastomosed rectum were evaluated histologically for mucosal integrity and for the location and density of inflammatory responses.
   Results: Fourteen pigs were assigned to either the treatment (n = 10) or control (n = 4) group. Of the pigs in the treatment group, 90% had complete closure of their rectal defect, as compared with 25% of the animals in the control group (chi(2) test, p = 0.04). The animals in the treatment group had only minimal mucosal and serosal inflammation, whereas those in the control group had extensive mucosal damage with associated serositis.
   Conclusions: Endoluminal negative-pressure therapy was well-tolerated and led to successful closure of 90% of the anastomic rectal defects in the treatment group of animals in the present study. Additional evaluation of this therapy is warranted.
C1 [Shada, Amber L.; Rosenberger, Laura H.] Univ Virginia Hlth Syst, Dept Surg, Charlottesville, VA USA.
   [Mentrikoski, Mark J.] Univ Virginia Hlth Syst, Dept Pathol, Charlottesville, VA USA.
   [Silva, Michael A.] Univ Virginia Hlth Syst, Dept Med, Charlottesville, VA USA.
   [Feldman, Sanford H.] Univ Virginia, Ctr Comparat Med, Charlottesville, VA 22908 USA.
   [Kleiner, Daniel E.] Washington Univ, Dept Surg, St Louis, MO USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; Washington University (WUSTL)
RP Shada, AL (通讯作者)，Univ Virginia, Dept Surg, POB 800300, Charlottesville, VA 22908 USA.
EM as4em@virginia.edu
RI ; Feldman, Sanford/AAH-7070-2021
OI Rosenberger, Laura/0000-0002-6829-6747; Feldman,
   Sanford/0000-0001-8041-8690
FU National Institutes of Health (NIH) [5-T32-AI-078875-02]; Hunter
   Surgical Corporation
FX Dr. Rosenberger is supported by National Institutes of Health (NIH)
   Grant 5-T32-AI-078875-02 from the National Institutes of Health. The
   remaining authors declare no grant funding. Additional support for this
   study was provided by a grant from Hunter Surgical Corporation. We thank
   Gina Wimer, Jeremy Gatesman, and the rest of the University of Virginia
   Center for Comparative Medicine staff for their help executing this
   project.
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NR 23
TC 11
Z9 13
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD APR
PY 2014
VL 15
IS 2
BP 123
EP 130
DI 10.1089/sur.2012.198
PG 8
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA AI9TS
UT WOS:000337282100009
PM 24476015
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Kairinos, N
   Pillay, K
   Solomons, M
   Hudson, DA
   Kahn, D
AF Kairinos, Nicolas
   Pillay, Kamlen
   Solomons, Michael
   Hudson, Donald A.
   Kahn, Delawir
TI The Influence Manufacturers Have on Negative-Pressure Wound Therapy
   Research
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MECHANISMS; SURGERY; DEVICE
AB Background: Studies investigating the effects of negative-pressure wound therapy using the Chariker-Jeter system (gauze-based interface) and the vacuum-assisted closure system often have outcomes that favor one particular system. This study attempts to examine whether manufacturer involvement could be related to the outcomes of these scientific studies.
   Methods: A literature review was undertaken to identify a cohort of studies that compared these two forms of negative-pressure wound therapy. Clinical outcomes studies, basic research studies, and published conference abstracts were included. All the articles' abstracts and conclusions were given to five surgeons, who were blinded to the titles and authors. They were individually asked to record what they would consider to be the take-home message of each article (in terms of which system is superior). After categorizing each study according to the system that it appears to favor, the level of manufacturer involvement in each study was evaluated. The relationship between the outcome of a study and the level of manufacturer involvement in that study was then investigated.
   Results: Of the total of 24 studies found to match the inclusion criteria, 22 were considered to favor a particular system (the other two were categorized as impartial). Of the 24 studies, 19 had some form of manufacturer involvement. Of the 19 that had some form of manufacturer involvement, 18 had outcomes that were deemed beneficial to the involved manufacturer, whereas one was deemed to have an impartial outcome.
   Conclusions: This study suggests that manufacturer involvement in these studies (regardless of level) correlates with the outcomes being beneficial to the involved manufacturer in almost all cases. Potential reasons for this and the implications thereof are discussed.
C1 Univ Cape Town, Dept Plast Surg, ZA-7925 Cape Town, South Africa.
   Univ Cape Town, Dept Surg, ZA-7925 Cape Town, South Africa.
   Univ Cape Town, Dept Orthopaed Surg, Martin Singer Hand Unit, ZA-7925 Cape Town, South Africa.
   Groote Schuur Hosp, ZA-7925 Cape Town, South Africa.
C3 University of Cape Town; University of Cape Town; University of Cape
   Town; University of Cape Town
RP Kairinos, N (通讯作者)，5 Pipit Lane, ZA-7441 Century City, Cape Town, South Africa.
EM nickykairinos@gmail.com
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NR 25
TC 22
Z9 23
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAY
PY 2014
VL 133
IS 5
BP 1178
EP 1183
DI 10.1097/PRS.0000000000000130
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AI9XR
UT WOS:000337300900051
PM 24445882
DA 2026-07-24
ER
PT J
AU Xia, CY
   Yu, AX
   Qi, BW
   Zhou, M
   Li, ZH
   Wang, WY
AF Xia, Cheng-Yan
   Yu, Ai-Xi
   Qi, Baiwen
   Zhou, Min
   Li, Zong-Huan
   Wang, Wei-Yang
TI Analysis of blood flow and local expression of angiogenesis-associated
   growth factors in infected wounds treated with negative pressure wound
   therapy
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE negative pressure wound therapy; angiogenesis-associated growth factors;
   protein biochip array; blood flow; infected wound
ID VACUUM-ASSISTED CLOSURE; IN-VIVO; DIABETIC MICE; TISSUE; CELLS; SKIN;
   EGF; ANGIOPOIETIN-2; LEPTIN; TRIAL
AB Angiogenesis is involved in the wound healing process. Increased angiogenesis and blood flow constitute a major mechanism of negative pressure wound therapy (NPWT), which has been shown to facilitate the healing of infected wounds. However, the effect on the expression of angiogensis-related growth factor remains unknown. The goal of the current study was to investigate the angiogenic factor levels prior to and following NPWT in infected wounds. A total of 20 patients with infected wounds treated with NPWT were included in the study. Patients acted as their own control; the postoperative measurements of patients were considered as the experimental group, while preoperative measurements were considered as the controlled group. Blood flow was recorded prior to and during NPWT. A total of 10 angiogensis-related growth factors were detected using a protein biochip array to analyze the change in protein levels prior to NPWT, and on the third day during NPWT. All wounds were successfully reconstructed by skin grafting or using local flaps following NPWT. NPWT resulted in significantly increased blood flow in the wound. There was a significant increase in vascular endothelial growth factor (VEGF), EGF, platelet-derived growth factor and angiotesin-2 following NPWT, while basic fibroblast growth factor decreased significantly. NPWT affects the local expression of angiogenesis-associated growth factors, which represents another mechanism to explain how NPWT accelerates wound healing.
C1 [Xia, Cheng-Yan; Yu, Ai-Xi; Qi, Baiwen; Zhou, Min; Li, Zong-Huan; Wang, Wei-Yang] Wuhan Univ, Dept Microorthopaed, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Dept Microorthopaed, Zhongnan Hosp, 169 East Lake Rd, Wuhan 430071, Hubei, Peoples R China.
EM yuaixi666@163.com
FU National Science Funds of China [81171713]; Doctoral candidate
   Independent research of Wuhan University [2012303020203]
FX This study was funded by grants from the National Science Funds of China
   (project code, 81171713), and by the Doctoral candidate Independent
   research of Wuhan University (grant no. 2012303020203).
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NR 42
TC 50
Z9 62
U1 0
U2 20
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAY
PY 2014
VL 9
IS 5
BP 1749
EP 1754
DI 10.3892/mmr.2014.1997
PG 6
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA AJ3HR
UT WOS:000337557600034
PM 24584462
OA Bronze
DA 2026-07-24
ER
PT J
AU Wang, WY
   Pan, ZY
   Hu, X
   Li, ZH
   Zhao, Y
   Yu, AX
AF Wang, Weiyang
   Pan, Zhenyu
   Hu, Xiang
   Li, Zonghuan
   Zhao, Yong
   Yu, Ai-Xi
TI Vacuum-assisted closure increases ICAM-1, MIF, VEGF and collagen I
   expression in wound therapy
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE severe traumatic wound; vacuum-assisted closure; intercellular adhesion
   molecule-1; migration inhibitory factor; collagen I
ID FIBROBLAST-GROWTH-FACTOR; MIGRATION INHIBITORY FACTOR; L-SELECTIN;
   TISSUE; METALLOPROTEINASES; FOUNDATION; MATRIX; DEVICE; MICE
AB Severe traumatic wounds are challenging to manage during surgery. The introduction of vacuum-assisted closure (VAC) is a breakthrough in wound management. The aim of the present study was to investigate the effect of VAC on cytokines in wounds during the management of severe traumatic wounds following initial debridement. VAC and conventional wound care (CWC) were independently applied to severe traumatic wounds on pigs. The expression levels of intercellular adhesion molecule-1 (ICAM-1), migration inhibitory factor (MIF), vascular endothelial growth factor (VEGF), basic fibroblast growth factor, collagen I and human fibroblast collagenase 1 were detected by quantitative polymerase chain reaction and western blotting. VAC significantly increased the expression of ICAM-1, MIF, VEGF and collagen I compared with that induced by CWC at the protein and mRNA levels. Therefore, the results of the present study indicate that VAC therapy is an effective method for treating severe traumatic wounds, as it increases the expression of cytokines in wounds. VAC significantly increases the expression of ICAM-1, MIF, VEGF and collagen I to manage severe traumatic wounds.
C1 [Wang, Weiyang; Pan, Zhenyu; Hu, Xiang; Li, Zonghuan; Zhao, Yong; Yu, Ai-Xi] Wuhan Univ, Zhongnan Hosp, Dept Microorthoped, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Microorthoped, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM yuaixi666@hotmail.com
OI Yu, Aixi/0000-0002-3751-0894
FU National Natural Science Funds of China [81171713]
FX The authors thank Wuhan VSD Medical Science & Technology, Co., Ltd.
   (Wuhan, China) for supplying the vacuum pump. The study was financed by
   a grant from the National Natural Science Funds of China (no. 81171713).
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NR 31
TC 20
Z9 24
U1 0
U2 15
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAY
PY 2014
VL 7
IS 5
BP 1221
EP 1226
DI 10.3892/etm.2014.1567
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AJ3HS
UT WOS:000337557700029
PM 24940415
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Willy, C
AF Willy, Christian
TI Breakthrough ideas leading to new futures: next steps
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE ABThera (TM) therapy; Incisions; NPWT; Open abdomen; Prevena (TM)
   therapy
AB In 2010, the educational International Surgical Wound Forum (ISWF) was created to facilitate discussion among global experts regarding modern wound treatment challenges and how negative pressure wound therapy (NPWT) could be used to address those challenges. This is the second of two supplements, which are based on 2012 and 2013 ISWF presentations and demonstrate the evolution of NPWT's role in wound care. The previous supplement provided an overview of critical health care issues and current clinical practice and reviewed evidence and experience using NPWT with instillation of topical wound solutions. This supplement presents clinical experience using negative pressure over closed surgical incisions, in the open abdomen, and in wounds with enteroatmospheric fistulas.
C1 [Willy, Christian] Bundeswehrkrankenhaus Berlin, Dept Traumatol & Orthopaed Sept & Plast Surg, D-10115 Berlin, Germany.
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Berlin, Colonel Dept Traumatol & Orthopaed Sept & Plast S, Scharnhorststr 13, D-10115 Berlin, Germany.
EM christianwilly@bundeswehr.org
NR 0
TC 0
Z9 0
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
SU 1
SI SI
BP 1
EP 2
DI 10.1111/iwj.12236
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AJ3MO
UT WOS:000337570900001
PM 24851727
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Brem, MH
   Bail, HJ
   Biber, R
AF Brem, Matthias H.
   Bail, Hermann J.
   Biber, Roland
TI Value of incisional negative pressure wound therapy in orthopaedic
   surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Incisional negative pressure wound therapy; Incisions; Infection;
   Traumatic wounds; Wound complications
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISIONS; FRACTURES
AB Soft tissue and wound treatment after orthopaedic interventions especially after trauma) is still an enormously challenging situation for every surgeon. Since development of negative pressure wound therapy (NPWT), new indications have been consistently added to the original field of application. Recently, NPWT has been applied directly over high-risk closed surgical incisions. Review of the literature indicates that this therapy has shown positive effects on incisions after total ankle replacement or calcaneal fractures, preventing haematoma and wound dehiscence. In those cases reduced swelling, decreased pain and healing time of the wound were seen. Additionally, NPWT applied on incisions after acetabular fractures showed a decreased rate of infection and wound healing problems compared with published infection rates. Even after total hip arthroplasty, incisional NPWT reduced incidence of postoperative seroma and improved wound healing. In patients with tibial plateau, pilon or calcaneus fractures requiring surgical stabilisation after blunt trauma, reduced risk of developing acute and chronic wound dehiscence and infection was observed when using incisional NPWT. To conclude, incisional NPWT can help to reduce risk of delayed wound healing and infection after severe trauma and orthopaedic interventions.
C1 [Brem, Matthias H.; Bail, Hermann J.; Biber, Roland] Univ Erlangen Nurnberg, Dept Trauma & Orthopaed Surg, Teaching Hosp, Nurnberg, Germany.
C3 University of Erlangen Nuremberg
RP Brem, MH (通讯作者)，Klinikum Nuernberg, Dept Trauma & Orthopaed Surg, Breslauer Str 201, D-90471 Nurnberg, Germany.
EM Matthias.Brem@klinikum-nuernberg.de
RI Biber, Roland/AAP-6691-2021
OI Biber, Roland/0000-0002-7700-0311
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   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Voinchet V, 1996, Ann Chir Plast Esthet, V41, P583
   Wolvos Tom, 2004, Ostomy Wound Manage, V50, P56
NR 15
TC 27
Z9 31
U1 1
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
SU 1
SI SI
BP 3
EP 5
DI 10.1111/iwj.12252
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AJ3MO
UT WOS:000337570900002
PM 24851728
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Grauhan, O
   Navasardyan, A
   Tutkun, B
   Hennig, F
   Müller, P
   Hummel, M
   Hetzer, R
AF Grauhan, Onnen
   Navasardyan, Artashes
   Tutkun, Baris
   Hennig, Felix
   Mueller, Peter
   Hummel, Manfred
   Hetzer, Roland
TI Effect of surgical incision management on wound infections in a
   poststernotomy patient population
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Mediastinitis; Poststernotomy infection; Prevena Therapy; Surgical
   incision management; Surgical site infection
ID POSTOPERATIVE MEDIASTINITIS; THERAPY
AB Skin breakdown and infiltration of skin flora are key causative elements in poststernotomy wound infections. We hypothesised that surgical incision management (SIM) using negative pressure wound therapy over closed surgical incisions for 6-7 days would reduce wound infections in a comprehensive poststernotomy patient population. 'All comers' undergoing median sternotomy at our institution were analysed prospectively from 1 September to 15 October 2013 (study group, n=237) and retrospectively from January 2008 to December 2009 (historical control group, n=3508). The study group had SIM ( Prevena (TM) Therapy) placed immediately after skin suturing and applied at -125 mmHg for 6-7 days, whereas control group received conventional sterile wound tape dressings. Primary endpoint was wound infection within 30 days. Study group had a significantly lower infection rate than control group: 1.3% (3 patients) versus 3.4% (119 patients), respectively (P<0.05; odds ratio 2.74). In the study group, when the foam dressing was removed after 6-7 days, the incision was primarily closed in 234 of 237 patients (98.7%). SIM over clean, closed incisions for the first 6-7 postoperative days significantly reduced the incidence of wound infection after median sternotomy. Based on these data SIM may be cost- effective in patients undergoing cardiac surgery.
C1 [Grauhan, Onnen; Navasardyan, Artashes; Tutkun, Baris; Hennig, Felix; Mueller, Peter; Hetzer, Roland] Deutsch Herzzentrum Berlin, Dept Cardiothorac & Vasc Surg, D-13353 Berlin, Germany.
   [Hummel, Manfred] Paulinen Krankenhaus, Dept Internal Med, Berlin, Germany.
C3 German Heart Center Berlin
RP Grauhan, O (通讯作者)，Deutsch Herzzentrum Berlin, Dept Cardiothorac & Vasc Surg, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM Grauhan@dhzb.de
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
   Doss M, 2002, EUR J CARDIO-THORAC, V22, P934, DOI 10.1016/S1010-7940(02)00594-8
   DURHAM SJ, 2008, CARDIAC SURG ADULT, P535
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Gårdlund B, 2002, EUR J CARDIO-THORAC, V21, P825, DOI 10.1016/S1010-7940(02)00084-2
   Gelape Cláudio Léo, 2007, Arq. Bras. Cardiol., V89, pe3
   Graf K, 2010, EUR J CARDIO-THORAC, V37, P893, DOI 10.1016/j.ejcts.2009.10.005
   Grauhan O, 2013, J THORAC CARDIOV SUR, V145, P1387, DOI 10.1016/j.jtcvs.2012.09.040
   Pachowsky M, 2012, INT ORTHOP, V36, P719, DOI 10.1007/s00264-011-1321-8
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Stannard JR, 2009, OSTOMY WOUND MANAG, V55, P58
NR 11
TC 62
Z9 71
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
SU 1
SI SI
BP 6
EP 9
DI 10.1111/iwj.12294
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AJ3MO
UT WOS:000337570900003
PM 24851729
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Weir, G
AF Weir, Gregory
TI The use of a surgical incision management system on vascular surgery
   incisions: a pilot study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE SIM; Surgical incision management; Surgical site infection; Vascular
   surgery
ID INFECTIONS
AB Health care-associated infections in hospitals, including surgical site infections, contribute significantly to morbidity as well as mortality. Surgical incision management (SIM) using negative pressure wound therapy (Prevena (TM) Incision Management System, Kinetic Concepts, Inc., San Antonio, TX, USA) is designed to cover and protect closed surgical incisions from external factors including infectious sources and local trauma, while negative pressure removes fluid and infectious material from the surgical incision. A prospective case-control study assessed wound complications in patients undergoing vascular bypass procedures, where both femoral areas were incised to gain access to the femoral arteries. SIM was placed on one femoral area while a standard postoperative wound dressing was placed on the contralateral femoral area. Eight patients were included in this pilot study. All of them required bilateral femoral artery access. During the follow-up period patients were monitored for wound complications. All wound complications requiring surgical intervention were considered significant. No significant wound complications occurred in wounds treated with SIM, compared with three significant complications in control wounds. These preliminary data would suggest a potential reduction in wound complications and no observed increase in haemorrhage in high-risk patients with severe co-morbidities undergoing vascular surgery.
C1 Eugene Marais Hosp, Vasc & Hyperbar Unit, Pretoria, South Africa.
RP Weir, G (通讯作者)，Eugene Marais Hosp, Vasc & Hyperbar Unit, POB 26091, Pretoria, South Africa.
EM gweir@vascular.co.za
CR [Anonymous], 2010, HLTH CARE ACQUIRED I
   Klevens RM, 2007, PUBLIC HEALTH REP, V122, P160, DOI 10.1177/003335490712200205
   Scott R.D., 2009, The direct medical costs of healthcare associated infections in US hospitals and the benefits of prevention
   1996, AM J INFECT CONTROL, V24, P380
NR 4
TC 15
Z9 16
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
SU 1
SI SI
BP 10
EP 12
DI 10.1111/iwj.12261
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AJ3MO
UT WOS:000337570900004
PM 24851730
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Terzi, C
   Egeli, T
   Canda, AE
   Arslan, NC
AF Terzi, Cem
   Egeli, Tufan
   Canda, Aras E.
   Arslan, Naciye C.
TI Management of enteroatmospheric fistulae
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Enteroatmospheric fistula; Negative pressure wound therapy; Open abdomen
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; SMALL-BOWEL
   FISTULAS; OPEN ABDOMEN; ENTEROCUTANEOUS FISTULAS; INTESTINAL
   FISTULIZATION; PERITONITIS; TRAUMA; SYSTEM; WOUNDS
AB A small-bowel enteroatmospheric fistula (EAF) is an especially challenging complication for patients with open abdomens (OAs) and their surgeons. Manipulation of the bowel during treatment (e.g. dressing changes) is one of the risk factors for developing these openings between the atmosphere and the gastrointestinal tract. Unlike enterocutaneous fistulae, EAFs have neither overlying soft tissue nor a real fistula tract, which reduces the likelihood of their spontaneous closure. Surgical closure is necessary but not always easy to do in the OA environment. Negative pressure wound therapy (NPWT) has been used successfully as an adjunct therapy to heal the wound around EAFs. This review discusses many aspects of managing EAFs in patients with OAs, and presents techniques that have been developed to isolate the fistula and divert effluent while applying NPWT to the surrounding wound bed.
C1 [Terzi, Cem; Egeli, Tufan; Canda, Aras E.; Arslan, Naciye C.] Dokuz Eylul Univ Hosp, Dept Surg, TR-35340 Izmir, Turkey.
C3 Dokuz Eylul University
RP Terzi, C (通讯作者)，Dokuz Eylul Univ Hosp, Dept Surg, TR-35340 Izmir, Turkey.
EM cem.terzi@deu.edu.tr
RI Arslan, N Cigdem/IUQ-1419-2023; Egeli, Tufan/B-5796-2019; Canda,
   Aras/O-7445-2019
OI Arslan, N Cigdem/0000-0002-2282-7207; 
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
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NR 31
TC 33
Z9 40
U1 0
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
SU 1
SI SI
BP 17
EP 21
DI 10.1111/iwj.12288
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AJ3MO
UT WOS:000337570900006
PM 24851732
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ozer, MT
   Sinan, H
   Zeybek, N
   Peker, Y
AF Ozer, M. Tahir
   Sinan, Huseyin
   Zeybek, Nazif
   Peker, Yusuf
TI A simple novel technique for enteroatmospheric fistulae: silicone
   fistula plug
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE EAF; Enteroatmospheric fistula; Negative pressure wound therapy; NPWT;
   Open abdomen
ID OPEN ABDOMEN; MANAGEMENT
AB Enteroatmospheric fistulae (EAFs), a rare condition that develops in patients treated with an open abdomen, present serious problems for the surgeon. There are no fixed algorithms for treatment of EAF, and treatment options are determined based on the experience of the surgeon and status of the patient. We developed a 'suspended silicone fistula plug' for treating a patient who developed an EAF after undergoing multiple operations in a short period of time. Used in conjunction with negative pressure wound therapy, application of this novel therapy resulted in EAF closure and patient discharge.
C1 [Ozer, M. Tahir; Sinan, Huseyin; Zeybek, Nazif; Peker, Yusuf] Gulhane Mil Med Acad, Dept Gen Surg, Ankara, Turkey.
C3 Gulhane Training & Research Hospital
RP Ozer, MT (通讯作者)，Gulhane Mil Med Acad, Dept Gastrointestinal Surg, Ankara, Turkey.
EM mtahirozer@gmail.com
OI Zeybek, Nazif/0000-0001-5033-834X
CR D'Hondt M, 2011, AM J SURG, V202, pE20, DOI 10.1016/j.amjsurg.2010.06.025
   Di Saverio S, 2011, J TRAUMA, V71, P760, DOI 10.1097/TA.0b013e318216e340
   Dubose Joseph J, 2010, Clin Colon Rectal Surg, V23, P182, DOI 10.1055/s-0030-1262986
   Jannasch O, 2011, ZBL CHIR, V136, P585, DOI 10.1055/s-0031-1271428
   Marinis A, 2009, SURG INFECT, V10, P47, DOI 10.1089/sur.2008.044
   Polk TM, 2012, WORLD J SURG, V36, P524, DOI 10.1007/s00268-011-1315-0
   Prichayudh S, 2011, SURG TODAY, V41, P72, DOI 10.1007/s00595-009-4202-7
NR 7
TC 14
Z9 17
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
SU 1
SI SI
BP 22
EP 24
DI 10.1111/iwj.12308
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AJ3MO
UT WOS:000337570900007
PM 24851733
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ozer, MT
   Coskun, AK
   Sinan, H
   Saydam, M
   Akay, EO
   Peker, S
   Ogunc, G
   Demirbas, S
   Peker, Y
AF Ozer, M. Tahir
   Coskun, Ali K.
   Sinan, Huseyin
   Saydam, Mehmet
   Akay, Emin O.
   Peker, Subutay
   Ogunc, Gokhan
   Demirbas, Sezai
   Peker, Yusuf
TI Use of self-expanding covered stent and negative pressure wound therapy
   to manage late rectal perforation after injury from an improvised
   explosive device: a case report
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Blast injuries; High-energy perineal trauma; Stents; Vacuum-assisted
   closure; Wound care
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; TRIAL; OBSTRUCTION;
   SURGERY; VAC(TM)
AB Blast injuries, caused by explosions accompanied by high-pressure waves, produce tissue damage in the acute period, followed in the later period by circulatory disorders due to vascular endothelial damage and related tissue necrosis. Blunt rectal perforation is rare and difficult to diagnose. In the acute period following blast pelvic injuries, the main objectives are to stop bleeding, minimise contamination and preserve the patient's life. The patient in this report had major vascular injuries, severe pelvic injury and, in the later period, rectal perforation because of vascular endothelial damage caused by the blast effect. Our aim was to treat the patient conservatively because of his poor general condition. We placed a self-expanding covered stent (SECS) into the rectum and then applied negative pressure wound therapy (NPWT; V.A.C.(R) Therapy, KCI) to the pelvic region and perirectal area. At the end of the treatment, the rectal perforation was closed, and the patient was discharged with healing. In this article, we discuss the novel use of an SECS with NPWT and review related literature.
C1 [Ozer, M. Tahir; Coskun, Ali K.; Peker, Subutay; Demirbas, Sezai; Peker, Yusuf] Gulhane Mil Med Acad, Dept Gen Surg, TR-06018 Ankara, Turkey.
   [Sinan, Huseyin; Saydam, Mehmet] Ankara Mevki Mil Hosp, Dept Gen Surg, Ankara, Turkey.
   [Akay, Emin O.] Gulhane Mil Med Acad, Dept Urol, TR-06018 Ankara, Turkey.
   [Ogunc, Gokhan] Ankara Police Dept, Dept Criminol, Ankara, Turkey.
C3 Gulhane Training & Research Hospital; Mevki Military Hospital; Gulhane
   Training & Research Hospital; Ministry of Interior - Turkey
RP Ozer, MT (通讯作者)，Gulhane Mil Med Acad, Dept Gen Surg, TR-06018 Ankara, Turkey.
EM mtahirozer@gmail.com
RI /R-8767-2019; /ACE-3488-2022; /J-2289-2015
OI SAYDAM, Mehmet/0000-0003-0953-4589; 
CR Baron TH, 2003, GASTROINTEST ENDOSC, V58, P421, DOI 10.1067/S0016-5107(03)00023-3
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NR 20
TC 2
Z9 2
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
SU 1
SI SI
BP 25
EP 29
DI 10.1111/iwj.12287
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AJ3MO
UT WOS:000337570900008
PM 24851734
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Ryan, SP
   Pugliano, V
AF Ryan, S. P.
   Pugliano, V.
TI CONTROVERSIES IN INITIAL MANAGEMENT OF OPEN FRACTURES
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Review
DE Open fracture; antibiotic; negative pressure wound therapy
ID OPEN TIBIAL FRACTURES; PRESSURE WOUND THERAPY; LONG-BONE FRACTURES;
   SURGICAL DEBRIDEMENT; DEEP INFECTION; TIME-DELAY; COVERAGE; LEG;
   COMPLICATIONS; ANTIBIOTICS
AB Background: Treatment of open fractures continues to be a challenge for orthopedic and trauma surgeons, and early treatment recommendations, which persist in the literature for decades, often do not have supporting data.
   Methods: This is a critical review of the literature surrounding controversies in the initial management of open fractures. It also focuses on the utility of negative pressure dressings in the care of associated complex wounds. Studies were selected based on their relevance to the treatment of open fractures.
   Results: A total of 40 studies were included. The following topics were critically discussed: timing of initial debridement, antibiotic coverage, utility of obtaining cultures, and timing of wound closure.
   Conclusion: The majority of open fractures require urgent, not emergent, irrigation and debridement. Antibiotics are essential in preventing infection in open fractures. Timely wound closure after all necrotic tissue has been debrided decreases complications in open fractures. Finally, negative pressure wound therapy has dramatically changed the care of associated complex wounds.
C1 [Ryan, S. P.; Pugliano, V.] Tufts Med Ctr, Dept Orthopaed Surg, Boston, MA 02111 USA.
C3 Tufts Medical Center
RP Ryan, SP (通讯作者)，Tufts Med Ctr, Dept Orthopaed Surg, Biewend 8th Floor,800 Washington St Box 306, Boston, MA 02111 USA.
EM sryan3@tuftsmedicalcenter.org
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   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
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NR 40
TC 30
Z9 33
U1 0
U2 18
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD JUN
PY 2014
VL 103
IS 2
BP 132
EP 137
DI 10.1177/1457496913519773
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AJ3NL
UT WOS:000337573400008
PM 24737846
DA 2026-07-24
ER
PT J
AU Zheng, YR
   Wang, XG
   Zhang, LP
   You, CG
   Feng, ZZ
   Han, CM
AF Zheng, Yurong
   Wang, Xingang
   Zhang, Liping
   You, Chuangang
   Feng, Zhanzeng
   Han, Chunmao
TI Successful Treatment of a Patient With Complicated Diabetic Foot Wound:
   A Case Report
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE diabetic foot; multimodal therapies; patient compliance
ID DRESSINGS; DISEASE; ULCERS
AB Foot ulceration is one of the most serious complications of diabetes mellitus and may lead to amputation of the lower extremity. Timely prophylaxis and treatment of diabetic foot ulceration are important to maintain a good quality of life. This article reports a complicated diabetic patient with severe limb-threatening necrotizing infection. We successfully applied endovascular stent insertion, digit amputation, negative pressure wound therapy, and advanced dressings in different wound phases to achieve definitive wound healing after 12 months of treatment. Based on this case report, we would like to emphasize the importance of combined multiple therapies and patient compliance for severe diabetic foot ulcers.
C1 [Zheng, Yurong; Wang, Xingang; Zhang, Liping; You, Chuangang; Feng, Zhanzeng; Han, Chunmao] Zhejiang Univ, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Han, CM (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Coll Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China.
EM hanchunmao1@126.com
OI Zheng, Yurong/0000-0002-1224-4796
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Barnea Y, 2010, THER CLIN RISK MANAG, V6, P21
   Beckman JA, 2002, JAMA-J AM MED ASSOC, V287, P2570, DOI 10.1001/jama.287.19.2570
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   Broughton G, 2006, PLAST RECONSTR SURG, V117, p12S, DOI 10.1097/01.prs.0000225430.42531.c2
   Dubsky M, 2013, INT WOUND J, V10, P555, DOI 10.1111/j.1742-481X.2012.01022.x
   Dyet JF, 2000, DIABETES-METAB RES, V16, pS16, DOI 10.1002/1520-7560(200009/10)16:1+<::AID-DMRR131>3.3.CO;2-N
   Frykberg RG, 2015, INT WOUND J, V12, P53, DOI 10.1111/iwj.12050
   Gregg EW, 2004, DIABETES CARE, V27, P1591, DOI 10.2337/diacare.27.7.1591
   Hilton JR, 2004, CLIN INFECT DIS, V39, pS100, DOI 10.1086/383270
   Hobizal KB, 2012, DIABET FOOT ANKLE, V3, DOI 10.3402/dfa.v3i0.18409
   Jeffcoate WJ, 2003, LANCET, V361, P1545, DOI [10.1001/jama.2018.18323, 10.1001/jama.2018.18323]
   Kota Siva Krishna, 2013, J Cardiovasc Dis Res, V4, P79, DOI 10.1016/j.jcdr.2012.10.002
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   McLennan S, 2006, WOUND PRACT RES, V14, P8
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   Singh N, 2005, JAMA-J AM MED ASSOC, V293, P217, DOI 10.1001/jama.293.2.217
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   Vaneau M, 2007, ARCH DERMATOL, V143, P1291, DOI 10.1001/archderm.143.10.1291
NR 21
TC 2
Z9 3
U1 2
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD JUN
PY 2014
VL 13
IS 2
BP 140
EP 146
DI 10.1177/1534734614529650
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AJ3NW
UT WOS:000337574600012
PM 24743750
DA 2026-07-24
ER
PT J
AU Hagiya, H
   Matsumoto, M
   Yamasawa, T
   Haruki, Y
   Otsuka, F
AF Hagiya, Hideharu
   Matsumoto, Mitsuaki
   Yamasawa, Takahiko
   Haruki, Yuto
   Otsuka, Fumio
TI A Case of Vascular Graft Infection Caused by Staphylococcus
   lugdunensis after Femoropopliteal Bypass Operation
SO ACTA MEDICA OKAYAMA
LA English
DT Article
DE coagulase-negative Staphylococcus (CNS); femoropopliteal (FP) bypass;
   Staphylococcus lugdunensis; vacuum-assisted closure (VAC) therapy;
   vascular graft infection (VGI)
ID CLINICAL-PRACTICE GUIDELINES; CHLORHEXIDINE; ENDOCARDITIS; FREQUENCY;
   TRIAL
AB A 79-year-old man who had undergone a right femoropopliteal (FP) bypass operation 6 weeks previously was diagnosed with vascular graft infection caused by Staphylococcus lugdunensis. Another FP bypass operation was performed, with long-term administration of antibiotics, and the patient eventually recovered well without any recurrences for over 2 years. Although S. lugdunens is classified as coagulase-negative Staphylococcus, its pathogenicity has been reported to be equal to that of S. aureus. Based on the literature review, the organism characteristically colonizes the inguinal area of human skin; thus, operations such as FP bypass grafting may place patients at a relatively high risk for infection by S. lugdunensis, a potentially high-pathogenicity organism.
C1 [Hagiya, Hideharu; Otsuka, Fumio] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Med, Okayama 7008558, Japan.
   [Hagiya, Hideharu] Tsuyama Cent Hosp, Emergency Unit, Tsuyama, Okayama 7080841, Japan.
   [Hagiya, Hideharu] Tsuyama Cent Hosp, Crit Care Ctr, Tsuyama, Okayama 7080841, Japan.
   [Matsumoto, Mitsuaki; Yamasawa, Takahiko] Tsuyama Cent Hosp, Dept Cardiac Surg, Tsuyama, Okayama 7080841, Japan.
   [Haruki, Yuto] Tsuyama Cent Hosp, Dept Pharm, Tsuyama, Okayama 7080841, Japan.
C3 Okayama University
RP Hagiya, H (通讯作者)，Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Med, Okayama 7008558, Japan.
EM e_dai_for_all@hotmail.com
CR Anderson DJ, Infect
   Braithwaite BD, 1998, BRIT J SURG, V85, P1378
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NR 32
TC 0
Z9 3
U1 0
U2 4
PU OKAYAMA UNIV MED SCHOOL
PI OKAYAMA
PA EDITORIAL OFFICE, ACTA MEDICA OKAYAMA OKAYAMA UNIVERSITY MEDICAL SCHOOL
   2-5-1 SHIKATA-CHO, KITA-KU, OKAYAMA, 700-8558, JAPAN
SN 0386-300X
J9 ACTA MED OKAYAMA
JI Acta Med. Okayama
PD JUN
PY 2014
VL 68
IS 3
BP 171
EP 175
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AJ4OL
UT WOS:000337655600007
PM 24942796
DA 2026-07-24
ER
PT J
AU Sawada, T
   Asai, J
   Nomiyama, T
   Masuda, K
   Takenaka, H
   Katoh, N
AF Sawada, Takahiro
   Asai, Jun
   Nomiyama, Tomoko
   Masuda, Koji
   Takenaka, Hideya
   Katoh, Norito
TI Trigeminal trophic syndrome: Report of a case and review of the
   published work
SO JOURNAL OF DERMATOLOGY
LA English
DT Review
DE craniotomy; review; therapeutics; trigeminal nerve injuries; trigeminal
   trophic syndrome
AB Trigeminal trophic syndrome is a rare complication of trigeminal nerve injury that causes facial ulceration, anesthesia and paresthesia in the same trigeminal dermatomes. We present a case of a 65-year-old woman with a history of meningioma resection 18 years prior who presented 16 years later with an intractable ulceration around her left nasolabial sulcus. Pain and light-touch sensations around the ulcer were decreased. She admitted to frequent manipulation due to a crawling sensation. A skin biopsy showed acanthotic changes and a decreased number of peripheral nerve fibers. Trigeminal trophic syndrome was diagnosed. Carbamazepine was not effective, and the ulcer persisted at 7 months after the initial presentation. We reviewed 36 English-language publications from 2003 to 2012, and analyzed 61 cases of trigeminal trophic syndrome, including this patient. The mean age was 53.3 +/- 19.7 years (range, 6-91). The right side of the face was more commonly affected (57%) than the left side. The ala nasi were involved in 48 cases (79%), followed by the cheek in 17 cases (28%). A corneal lesion was observed in 11 cases (18%), suggesting the importance of ophthalmologic consultations. The two major etiologies were trigeminal nerve ablation (18 cases; 30%) and cerebrovascular accidents (18 cases; 30%). The latent period ranged from days to 30 years. Gabapentin and carbamazepine were frequently administrated with variable efficacy. Application of thermoplastic dressings or negative pressure wound therapy demonstrated favorable outcomes. Surgery was an option with a high recurrence rate. Trigeminal trophic syndrome remains a clinical challenge.
C1 [Sawada, Takahiro; Asai, Jun; Nomiyama, Tomoko; Masuda, Koji; Takenaka, Hideya; Katoh, Norito] Kyoto Prefectural Univ Med, Dept Dermatol, Kyoto 6028566, Japan.
C3 Kyoto Prefectural University of Medicine
RP Sawada, T (通讯作者)，Kyoto Prefectural Univ Med, Dept Dermatol, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan.
EM tasawa@koto.kpu-m.ac.jp
RI Asai, Jun/AAD-4796-2020
OI Asai, Jun/0000-0002-7610-0820
CR Fredeking AE, 2008, ARCH DERMATOL, V144, P984, DOI 10.1001/archderm.144.8.984
   Frühauf J, 2008, MAYO CLIN PROC, V83, P502, DOI 10.4065/83.4.502
   Garza I, 2008, CEPHALALGIA, V28, P980, DOI 10.1111/j.1468-2982.2008.01636.x
   Luksic I, 2008, J NEUROSURG, V108, P170, DOI 10.3171/JNS/2008/108/01/0170
   Mishra SN, 2011, INDIAN J DERMATOL VE, V77, DOI 10.4103/0378-6323.86501
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NR 15
TC 41
Z9 45
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD JUN
PY 2014
VL 41
IS 6
BP 525
EP 528
DI 10.1111/1346-8138.12490
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AJ4ZK
UT WOS:000337689100009
PM 24807466
DA 2026-07-24
ER
PT J
AU Bulla, A
   Farace, F
   Uzel, AP
   Casoli, V
AF Bulla, Antonio
   Farace, Francesco
   Uzel, Andre-Pierre
   Casoli, Vincent
TI Negative Pressure Wound Therapy and External Fixation Device: A Simple
   Way to Seal the Dressing
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy; bone wax
ID VACUUM-ASSISTED CLOSURE
AB Negative pressure therapy is widely applied to treat lower limb trauma. However, sealing a negative pressure dressing in the presence of an external fixation device may be difficult and time consuming. Therefore, screws, pins, wires, etc, may preclude the vacuum, preventing the plastic drape to perfectly adhere to the foam. To maintain the vacuum, we tried to prevent air leaking around the screws putting bone wax at the junction between the pins and the plastic drape. This solution, in our hands, avoids air leakage and helps maintain vacuum in a fast and inexpensive way.
C1 [Bulla, Antonio; Farace, Francesco] Univ Sassari, Univ Hosp Trust, Plast Surg Unit, Dept Surg Microsurg & Med Sci, Via Pasubio 5, I-07100 Sassari, Italy.
   [Bulla, Antonio] Univ Sassari, Univ Hosp Trust, Dept Biomed Sci, I-07100 Sassari, Italy.
   [Uzel, Andre-Pierre] CHU Pointe A Pitre, Serv Orthopedietraumatol, Pointe a Pitre, Guadeloupe, France.
   [Casoli, Vincent] CHU Bordeaux, Francois Xavier Michelet Ctr, Bordeaux, France.
C3 University of Sassari; University of Sassari; CHU Guadeloupe; Universite
   de Bordeaux; CHU Bordeaux
RP Bulla, A (通讯作者)，Univ Sassari, Univ Hosp Trust, Plast Surg Unit, Dept Surg Microsurg & Med Sci, Via Pasubio 5, I-07100 Sassari, Italy.
EM abulla80@gmail.com
CR Hardwicke Joseph, 2006, Int J Low Extrem Wounds, V5, P101, DOI 10.1177/1534734606288576
   Lemmon JA, 2008, PLAST RECONSTR SURG, V121, p234E, DOI 10.1097/01.prs.0000305394.80769.8b
   Ozer K, 2006, ANN PLAS SURG, V56, P693, DOI 10.1097/01.sap.0000203997.70550.f8
   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 5
TC 17
Z9 21
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD JUL
PY 2014
VL 28
IS 7
BP E176
EP E177
DI 10.1097/BOT.0000000000000013
PG 2
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA AJ5QC
UT WOS:000337739400005
PM 24296597
DA 2026-07-24
ER
PT J
AU Bird, JE
AF Bird, Justin E.
TI "Advances in the Surgical Management of Bone Tumors"
SO CURRENT ONCOLOGY REPORTS
LA English
DT Article
DE Bone tumor; Musculoskeletal surgery; Tumor resection; Navigation;
   Computer-assisted surgery; Negative pressure wound therapy; Orthopedic
   oncology; Technology; Megaprosthesis; Antibacterial coatings;
   Osteointegration; Orthopedic implants
ID COMPUTER NAVIGATION; OSTEOID OSTEOMA; ORTHOPEDIC-SURGERY;
   PROGNOSTIC-FACTORS; IMAGE GUIDANCE; RESECTION; CHONDROSARCOMA; PELVIS;
   RECONSTRUCTION; ACCURACY
AB Bone tumor surgery is extremely challenging, particularly when tumors are located in tightly confined anatomical areas and abutting critical organs and neurovascular structures. Tumor resection requires good cutting accuracy to ensure safety, to achieve negative margins, and to preserve critical structures when possible. The purpose of this paper was to review the literature on the surgical advances for bone tumor surgery published within the last year. The majority of literature identified focused on computer-assisted surgical approaches. There is increasing evidence that 3D navigation plays an important role in the resection of bone tumors. Reconstruction materials that encourage healing and prevent infections are also in development. Optimal care includes execution of a well-developed pre-operative plan using a multidisciplinary approach led by the orthopaedic oncologist.
C1 Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center
RP Bird, JE (通讯作者)，Univ Texas MD Anderson Canc Ctr, 1400 Pressler St Suite FCT 10-5054, Houston, TX 77030 USA.
EM jebird@mdanderson.org
OI Bird, Justin/0000-0002-7537-3018
CR Agrawal N, 2013, J RECONSTR MICROSURG, V29, P107, DOI 10.1055/s-0032-1329920
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NR 55
TC 8
Z9 9
U1 0
U2 20
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3790
EI 1534-6269
J9 CURR ONCOL REP
JI Curr. Oncol. Rep.
PD JUL
PY 2014
VL 16
IS 7
AR 392
DI 10.1007/s11912-014-0392-2
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AJ5RG
UT WOS:000337743000002
PM 24853049
DA 2026-07-24
ER
PT J
AU Dohmen, PM
   Misfeld, M
   Borger, MA
   Mohr, FW
AF Dohmen, Pascal M.
   Misfeld, Martin
   Borger, Michael A.
   Mohr, Friedrich W.
TI Closed incision management with negative pressure wound therapy
SO EXPERT REVIEW OF MEDICAL DEVICES
LA English
DT Review
DE negative pressure wound therapy; prevention; surgical site infections
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS;
   STAPHYLOCOCCUS-AUREUS; METHICILLIN-RESISTANT; SUBATMOSPHERIC PRESSURE;
   CARDIAC-SURGERY; INFECTIONS; COMPLICATIONS; PREVENTION; FRACTURES
AB Post-sternotomy mediastinitis is the most severe surgical site infection after sternotomy with an incidence between 1-4% related to the patient co-morbidity. This complication will increase morbidity and mortality and may also have an economic impact. There are guidelines to prevent surgical site infections; however, age and co-morbidities increase and therefore it is important to develop new tools to improve wound healing. This manuscript will give an overview of a new concept using negative pressure wound therapy over a closed incision (so-called, closed incision management) after surgery and will include the principles of negative pressure wound therapy and the positively applied mechanical forces as a permutation of Wolff's law. The use and indication of this therapy is supported by experimental studies divided into physiological and biomechanical property studies. Finally, an overview of clinical studies is given based on the evidence rating scale for therapeutic studies.
C1 [Dohmen, Pascal M.; Misfeld, Martin; Borger, Michael A.; Mohr, Friedrich W.] Univ Leipzig, Heart Ctr Leipzig, Dept Cardiac Surg, D-04289 Leipzig, Germany.
   [Dohmen, Pascal M.] Univ Free State, Dept Cardiothorac Surg, Bloemfontin, South Africa.
C3 Heart Center Leipzig GMBH; Leipzig University
RP Dohmen, PM (通讯作者)，Univ Leipzig, Heart Ctr Leipzig, Dept Cardiac Surg, Struempellstr 39, D-04289 Leipzig, Germany.
EM pascal.dohmen@yahoo.de
RI ; Borger, Michael/H-3553-2013
OI Misfeld, Martin/0000-0001-7940-0629; Borger, Michael/0000-0003-1046-1364
FU KCI Europe Holding B.V.
FX P Dohmen received research grants provided by KCI Europe Holding B.V.
   The authors have no other relevant affiliations or financial involvement
   with any organization or entity with a financial interest in or
   financial conflict with the subject matter or materials discussed in the
   manuscript apart from those disclosed. The authors would like to thank
   Julissa Ramos of KCI for editorial assistance with this review article
   preparation.
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NR 47
TC 17
Z9 19
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1743-4440
EI 1745-2422
J9 EXPERT REV MED DEVIC
JI Expert Rev. Med. Devices
PD JUL
PY 2014
VL 11
IS 4
BP 395
EP 402
DI 10.1586/17434440.2014.911081
PG 8
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA AJ5WF
UT WOS:000337760200008
PM 24754343
DA 2026-07-24
ER
PT J
AU Cook, SJ
   Nichols, FR
   Brunker, LB
   Bachus, KN
AF Cook, Saranne J.
   Nichols, Francesca R.
   Brunker, Lucille B.
   Bachus, Kent N.
TI A novel vacuum assisted closure therapy model for use with percutaneous
   devices
SO MEDICAL ENGINEERING & PHYSICS
LA English
DT Article
DE Animal model; Hairless rat; Negative-pressure wound therapy; Wound
   healing; Percutaneous device; Skin
ID PRESSURE WOUND THERAPY; MICROVASCULAR BLOOD-FLOW; OSSEOINTEGRATED
   PROSTHESES; HAIRLESS RAT; SKIN; IMPLANTS; INTERFACE; INFECTION; MOUSE
AB Long-term maintenance of a dermal barrier around a percutaneous prosthetic device remains a common clinical problem. A technique known as Negative Pressure Wound Therapy (NPWT) uses negative pressure to facilitate healing of impaired and complex soft tissue wounds. However, the combination of using negative pressure with percutaneous prosthetic devices has not been investigated. The goal of this study was to develop a methodology to apply negative pressure to the tissues surrounding a percutaneous device in an animal model; no tissue healing outcomes are presented. Specifically, four hairless rats received percutaneous porous coated titanium devices implanted on the dorsum and were bandaged with a semi occlusive film dressing. Two of these animals received NPWT; two animals received no NPWT and served as baseline controls. Over a 28-day period, both the number of dressing changes required between the two groups as well as the pressures were monitored. Negative pressures were successfully applied to the periprosthetic tissues in a clinically relevant range with a manageable number of dressing changes. This study provides a method for establishing, maintaining, and quantifying controlled negative pressures to the tissues surrounding percutaneous devices using a small animal model. Published by Elsevier Ltd on behalf of IPEM
C1 [Cook, Saranne J.; Nichols, Francesca R.; Bachus, Kent N.] Univ Utah, Orthopaed Res Lab, Orthopaed Ctr, Salt Lake City, UT 84108 USA.
   [Cook, Saranne J.; Nichols, Francesca R.; Brunker, Lucille B.; Bachus, Kent N.] Dept Vet Affairs Med Ctr, Bone & Joint Res Lab, Salt Lake City, UT 84148 USA.
   [Bachus, Kent N.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah; US Department of
   Veterans Affairs; Utah System of Higher Education; University of Utah
RP Bachus, KN (通讯作者)，Univ Utah, Orthopaed Res Lab, Orthopaed Ctr, 590 Wakara Way,Suite A100, Salt Lake City, UT 84108 USA.
EM kent.bachus@hsc.utah.edu
RI Bachus, Kent/KYO-7869-2024
OI Bachus, Kent/0000-0003-4435-6378
FU Department of Defense (BAA-10) [10091004]; Department of Orthopedics,
   University of Utah
FX The authors acknowledge funding from the Department of Defense (BAA-10
   (No. 10091004)). The Army Medical Research Acquisition Activity, 820
   Chandler Street, US Fort Detrick, MD 21702-5014 is the awarding and
   administering acquisition office. The content of the research does not
   necessarily reflect the position or the policy of the Government, and no
   official endorsement should be inferred. Funding is also provided in
   part by the Department of Orthopedics, University of Utah.
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NR 45
TC 2
Z9 2
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1350-4533
EI 1873-4030
J9 MED ENG PHYS
JI Med. Eng. Phys.
PD JUN
PY 2014
VL 36
IS 6
BP 768
EP 773
DI 10.1016/j.medengphy.2014.01.008
PG 6
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA AJ8CQ
UT WOS:000337930700017
PM 24685323
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Huang, CY
   Leavitt, T
   Bayer, LR
   Orgill, DP
AF Huang, Chenyu
   Leavitt, Tripp
   Bayer, Lauren R.
   Orgill, Dennis P.
TI Effect of negative pressure wound therapy on wound healing
SO CURRENT PROBLEMS IN SURGERY
LA English
DT Review
ID VACUUM-ASSISTED-CLOSURE; THICKNESS SKIN-GRAFTS; PROSPECTIVE
   RANDOMIZED-TRIAL; CLOSED INCISION MANAGEMENT; DIABETIC MOUSE MODEL;
   SUBATMOSPHERIC PRESSURE; TISSUE PRESSURE; DIFFERENT SIZES; BACTERIAL
   LOAD; EXPOSED BONE
C1 [Huang, Chenyu; Leavitt, Tripp; Orgill, Dennis P.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast Surg, Boston, MA 02115 USA.
   [Huang, Chenyu] Hebei United Univ, Meitan Gen Hosp, Dept Plast Surg, Beijing 100028, Peoples R China.
   [Leavitt, Tripp] Boston Univ, Sch Med, Boston, MA 02118 USA.
   [Bayer, Lauren R.; Orgill, Dennis P.] Brigham & Womens Hosp, Ambulatory Treatment Room & Wound Care Ctr, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; North China University of
   Science & Technology; Boston University; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital
RP Huang, CY (通讯作者)，Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast Surg, Boston, MA 02115 USA.
RI Huang, Chenyu/I-4410-2018; Orgill, Dennis/H-7596-2019
OI Huang, Chenyu/0000-0001-9521-5650; Leavitt, Tripp/0000-0001-7829-2646; 
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NR 121
TC 389
Z9 499
U1 4
U2 66
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0011-3840
EI 1535-6337
J9 CURR PROB SURG
JI Curr. Probl. Surg.
PD JUL
PY 2014
VL 51
IS 7
BP 301
EP 331
DI 10.1067/j.cpsurg.2014.04.001
PG 31
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AJ8TX
UT WOS:000337981700002
PM 24935079
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Liu, T
   Yang, F
   Li, ZF
   Yi, CL
   Bai, XJ
AF Liu, Tao
   Yang, Fan
   Li, Zhanfei
   Yi, Chengla
   Bai, Xiangjun
TI A Prospective Pilot Study to Evaluate Wound Outcomes and Levels of Serum
   C-reactive Protein and Interleukin-6 in the Wound Fluid of Patients with
   Trauma-related Chronic Wounds
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE trauma; chronic wound; C-reactive protein; interleukin-6; negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE THERAPY; GROWTH-FACTOR;
   INFECTION; CARE; MARKERS
AB If surgical closure of chronic wounds is an option, choosing an appropriate time to definitely close these wounds remains a challenge. Although the underlying mechanisms of nonhealing are not completely understood, serum C-reactive protein (CRP) and interleukin-6 (IL-6) in wound fluid have been found to be markers of the systemic and local inflammation state of chronic wounds. The purpose of this prospective, descriptive pilot study was to evaluate the effect of debridement, systemic antibiotics, and negative pressure wound therapy (NPWT) on the outcomes of trauma-related chronic wounds and changes in local inflammation responses, measured using CRP and IL-6 levels as indicators of cytokine regulation. Between June 2012 and May 2013, 20 consecutive patients (14 men, six women, mean age 40 [range 17-561 years) with various trauma-related, nonhealing chronic wounds were enrolled in the study after failing to heal for an average of 8.5 (range 6-16) weeks using a protocol of regular debridement and gauze dressings. Before the start of the study, wounds were cultured, and laboratory values for white blood cell count (WBC), neutrophils, and levels of serum CRP and IL-6 in the wound fluid obtained. Wounds were surgically debrided and NPWT (continuous at 125 mm Hg) applied. All patients were prescribed systemic antibiotics, and mean time interval between NPWT dressing changes was 5 (range 3-7) days. During an average mean NPWT treatment time of 13 (range 5-20) days, CRP and IL-6 concentrations decreased from 66.4 mg/L to 10.4 mg/L and 44.1 pg/mL to 8.6 pg/mL, respectively (P <0.001). The presence/absence of bacteria, WBC, and neutrophil counts did not change. No complications were noted, and all wounds were successfully closed using various surgical procedures. In this study, clinical wound improvement and a significant decrease in wound fluid CRP and IL-6 levels were observed. Studies with a larger sample size and a more robust study design may help elucidate the relationship between inflammatory molecules, infection, and healing outcomes.
C1 [Liu, Tao; Yang, Fan; Li, Zhanfei; Yi, Chengla; Bai, Xiangjun] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Traumat Surg, Wuhan 430074, Peoples R China.
C3 Huazhong University of Science & Technology
RP Bai, XJ (通讯作者)，Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Hangkong Rd 1095, Wuhan 430074, Peoples R China.
EM baixiangjun@hotmail.com
RI Li, Zhanfei/JQW-2611-2023; Liu, Tao/OZE-7740-2025
OI Bai, Xiangjun/0009-0003-4847-2285; Liu, Tao/0009-0009-7392-9260
FU Ministry of Health Industry Sector Funds [201002014]; National 12th
   Five-support program - Research and Integrate New Technology
   Demonstration of Trauma [2012BA111B00]; Hubei Science and Technology Key
   Project [2013CFA075]; Hubei Province's Outstanding Medical Academic
   Leader Program; National Nature Science Foundation of China [81271348]
FX Dr. Bai's efforts were supported by the Ministry of Health Industry
   Sector Funds (Item Number. 201002014), the National 12th Five-support
   program - Research and Integrate New Technology Demonstration of Trauma
   (Item Number. 2012BA111B00), Hubei Science and Technology Key Project
   (Item Number. 2013CFA075), and Hubei Province's Outstanding Medical
   Academic Leader Program. Dr. Yi received support from the National
   Nature Science Foundation of China (Grant No. 81271348).
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NR 37
TC 21
Z9 24
U1 0
U2 10
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2014
VL 60
IS 6
BP 30
EP 37
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AK0FU
UT WOS:000338089100006
PM 24905355
DA 2026-07-24
ER
PT J
AU Zhang, J
   Hu, ZC
   Chen, D
   Guo, D
   Zhu, JY
   Tang, B
AF Zhang, Jian
   Hu, Zhi-Cheng
   Chen, Dong
   Guo, Dong
   Zhu, Jia-Yuan
   Tang, Bing
TI Effectiveness and Safety of Negative-Pressure Wound Therapy for Diabetic
   Foot Ulcers: A Meta-Analysis
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; QUALITY; INTERVENTIONS; MULTICENTER;
   MANAGEMENT; ENHANCE
AB Background: The authors conducted a meta-analysis to evaluate the effectiveness and safety of negative-pressure wound therapy for diabetic foot ulcers.
   Methods: PubMed, EMBASE, and the Cochrane Library were searched to identify relevant studies published up to February of 2013. All randomized controlled trials comparing negative-pressure wound therapy and non-negative-pressure wound therapy (i.e., standard wound care) for diabetic foot ulcers were included. Results were pooled using meta-analysis to assess the efficacy and safety of negative pressure in managing diabetic foot ulcers.
   Results: The databases were derived from eight qualified studies that included a total of 669 patients. Overall, compared with the non-negative-pressure wound therapy-treated diabetic foot ulcers, negative pressure resulted in a significantly higher proportion of healed ulcers (relative risk, 1.52; 95 percent CI, 1.23 to 1.89; p < 0.001), more reduction of ulcer area (standardized mean difference, 0.89; 95 percent CI, 0.41 to 1.37; p = 0.003), and shorter time to wound healing (standardized mean difference, -1.10; 95 percent CI, -1.83 to -0.37; p = 0.003). Negative-pressure wound therapy patients also experienced significantly fewer major amputations (relative risk, 0.14; 95 percent CI, 0.04 to 0.51; p = 0.003), but the rate of minor amputations was not affected (p = 0.837). No significant difference was observed between negative-pressure wound therapy and non-negative-pressure wound therapy (p = 0.683). No heterogeneity among studies was detected.
   Conclusion: Negative-pressure wound therapy appears to be more effective for diabetic foot ulcers compared with non-negative-pressure wound therapy, and has a similar safety profile.
C1 [Tang, Bing] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burns & Plast Surg, Guangzhou 510080, Guangdong, Peoples R China.
   Sun Yat Sen Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Guangzhou 510080, Guangdong, Peoples R China.
   Sun Yat Sen Univ, Affiliated Hosp 3, Dept Plast Surg, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
RP Tang, B (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burns & Plast Surg, 58 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China.
EM tangbing@mail.sysu.edu.cn
RI dong, chen/GPF-6169-2022
FU National Natural Science Foundation of China [30973128, 81272096];
   Research Fund for the Doctoral Program of Higher Education of China
   [20110171110064]; Sun Yat-sen University Clinical Research 5010 Program
   [2013001]
FX This work was supported by research grants 30973128 and 81272096 from
   the National Natural Science Foundation of China, research grant
   20110171110064 from the Research Fund for the Doctoral Program of Higher
   Education of China, and research grant 2013001 from the Sun Yat-sen
   University Clinical Research 5010 Program.
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   MCCALLON S.K., 2000, Ostomy Wound Manage, V46, P28
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   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
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NR 36
TC 57
Z9 68
U1 0
U2 46
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUL
PY 2014
VL 134
IS 1
BP 141
EP 151
DI 10.1097/PRS.0000000000000275
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AK0PK
UT WOS:000338116400053
PM 24622569
DA 2026-07-24
ER
PT J
AU Raza, A
   Cuenca, AG
   Tan, S
   Singhal, D
AF Raza, Ahsan
   Cuenca, Alex G.
   Tan, Sanda
   Singhal, Dhruv
TI Omental Flaps for Coverage of Sacral or Gluteal Defects: A Useful and
   Potentially Underused Tool
SO AMERICAN SURGEON
LA English
DT Article; Proceedings Paper
CT Annual Scientific Meeting and Postgraduate Course Program of the
   Southeastern-Surgical-Congress
CY FEB 22-25, 2014
CL Savannah, GA
SP SE Surg Congress
ID RECONSTRUCTION
AB A 51-year-old man presented with a slowly growing mass arising from his left gluteus maximus muscle that measured 12 cm in its greatest dimension (Fig. 1A). Imaging demonstrated that the mass extended into the dorsal aspect of the sacrum. Preoperative staging of the neoplasm was T2bN0M0. The patient underwent preoperative radiation therapy before undergoing extirpation of the lesion including partial sacrectomy, partial iliac bone resection, and pelvic floor reconstruction. AGore-tex (TM) mesh was used to span the sacral defect and the wound was closed primarily. Unfortunately, a fall three weeks postprocedure resulted in wound dehiscence, exposing the underlying mesh. Negative pressure wound therapy was initially used as a temporizing approach given the performance status of the patient at that time. After improvement in the patient's nutritional and performance status, and the formation of a healthy wound bed, the decision was made for wound de bridement, colonic diversion, and omental flap coverage.
   The procedure began with the patient prone by incising the remaining intact prior inferolateral incision. The resulting wound was over 15 cm in size tracking inferomedially (Fig. 1A). The wound was debrided to healthy bleeding tissue. The preoperative plan was to pedicle the omental flap through Petit's triangle so as to avoid dissection around the rectum (Fig. 1B). We then dissected a subcutaneous tunnel from the right edge of the wound up to Petit's triangle on the right side (marked out with medial border being marked by the latissimus and inferior border being marked by thepossible immunocompromised conditions such as diabetes, poor nutrition, history of radiation to the affected area, and wound infections. Flap options include local flaps including muscle, fasciocutaneous skin flaps from the gluteal, back, or posterior thigh region. Other options include VRAM flap and pedicled omental flaps. Paraspinal muscles have been used with greater success for flat wounds but omentum is ideal for deep wounds as a result of its ability to be readily contoured. However, the approach taken for this patient is often not considered. In our case, the patient had radiotherapy to the gluteal region; therefore, local flap options were very limited. He also had a history of wound infection and debridement and needed reconstruction with well-vascularized tissue with the ability to overcome resistant bacterial infection. In such patients, transpelvic vertical rectus abdominis muscle flaps have been advocated. 1 The flap is detached from the pubis and the pelvis inset isiliac crest). The patient was then turned supine. The abdomen was opened with the midline incision proceeding to the left of the umbilicus to preserve the possibility of a left vertical rectus abdominis myocutaneous (VRAM) flap. Laparoscopy was also not performed in case a VRAM flap was needed. The omentum was freed from the distal transverse colon and greater curvature of the stomach and the flap was mobilized inferolaterally with vascular supply based on the right gastroepiploic artery. The cecum was mobilized medially to expose the region of Petit's triangle from the abdominal approach. The omentum was placed near the triangle for easy access in second part of the surgery. An end colostomy through the left rectus muscle was created and the abdominal fascia was closed. The patient was then turned prone.
   A 5-cm counterincision over the previously marked Petit's triangle was made and the omentum was delivered through the previously dissected space. As demonstrated in Figure 2A, complete coverage of the sacral defect was achieved. We then secured the omentum to the sacral wound using polydioxanone suture. The remainder of the omentum was used to fill the void of the left gluteal region. A superiorly oriented incision was then performed from the lateral edge of the initial incision thereby developing a superiorly based rotation advancement fasciocutaneous flap (18 5 cm). The fasciocutaneous flap was then advanced over the omentum and the wound was closed primarily. The patient was seen in clinic postoperatively six weeks after the operation (Fig. 2C). He was ambulating well. At three months, the sacral wound had healed well. The colostomy was reversed.
   Soft tissue reconstruction of the pelvis with vascularized tissue flaps is becoming an increasingly common procedure. The primary goal of such an operation is to restore form and function, obliterate dead space, and create an environment favorable to wound healing. Resections of tumors from the pelvis and presacral areas often leave deep and extensive defects, which are challenging for the surgeon to reconstruct. Other obstacles that hamper wound healing also include possible immunocompromised conditions such as diabetes, poor nutrition, history of radiation to the affected area, and wound infections. Flap options include local flaps including muscle, fasciocutaneous skin flaps from the gluteal, back, or posterior thigh region. Other options include VRAM flap and pedicled omental flaps. Paraspinal muscles have been used with greater success for flat wounds but omentum is ideal for deep wounds as a result of its ability to be readily contoured. However, the approach taken for this patient is often not considered.
   In our case, the patient had radiotherapy to the gluteal region; therefore, local flap options were very limited. He also had a history of wound infection and debridement and needed reconstruction with well-vascularized tissue with the ability to overcome resistant bacterial infection. In such patients, transpelvic vertical rectus abdominis muscle flaps have been advocated. (1)The flap is detached from the pubis and the pelvis inset isadvanced into the sacral defect. Because the operative plan included colonic diversion and colostomy creation, this approach was not considered ideal. Another flap that has been widely used in intraperitoneal and extraperitoneal defects because of its generous blood supply, large surface area, and angiogenic potential is an omental flap. It successfully fills dead spaces, induces angiogenesis, and is known to have immunological function. (2)These properties make it an effective option in treating infected, irradiated, or ischemic wounds.
   Anatomically, the omentum can be divided into greater and lesser omentum, gastrohepatic, and hepatoduodenal ligaments. For an omental pedicle flap, greater omentum is used with the vascular supply being from either the right or left gastroepiploic artery. Omental pedicle flap length can be varied depending on the volume needed at the recipient site. It is dissected from the transverse colon and greater curvatureof the stomach and tunneled laterally along the left or right colic gutter to the pelvic floor. (2)Petit's triangle is formed by the iliac crest, latissimus dorsi, and external oblique muscles. This can be used as a tunnel to bring the omentum posteriorly to cover sacral defects. Contraindications for the use of omental flaps include adhesions, prior surgeries, malignancies with peritoneal metastasis, or other concomitant abdominal disease. (3)The main disadvantage of using the omental flap is the combined anterior and posterior approach, which increases morbidity and creates problems with positioning. (4)Other complications may include small bowel obstruction, herniation, and fluid and electrolyte disturbances. The omental flap has also been used successfully in chest wall, scrotal, and penile reconstruction. Reconstructive options for large sacral defects, which have been previously irradiated and infected, are very limited. The possibilities that have been explored in this report include local flap options like gluteal, thigh, or back flaps as well as vertical rectus abdominis and pedicled omental flaps. When the surgeon cannot use local flaps or free tissue transfers, the omental flap with its rich vascular supply, contourability, and ability to fight infections can be used successfully through the Petit triangle to cover such defects. This is a safe option with good wound closure and healing and provides better results than the use of local flaps. It may be a particularly attractive option when colostomy is also indicated.
C1 [Raza, Ahsan; Cuenca, Alex G.; Tan, Sanda] Univ Florida, Coll Med, Dept Surg, Div Gen Surg, Gainesville, FL 32610 USA.
   [Singhal, Dhruv] Univ Florida, Coll Med, Dept Surg, Div Plast & Reconstruct Surg, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Tan, S (通讯作者)，Univ Florida, Coll Med, Dept Surg, Box 100019, Gainesville, FL 32610 USA.
EM sanda.tan@surgery.ufl.edu
CR GIORDANO PA, 1994, PLAST RECONSTR SURG, V93, P1508, DOI 10.1097/00006534-199406000-00030
   Hultman CS, 2010, ANN PLAS SURG, V64, P559, DOI 10.1097/SAP.0b013e3181ce3947
   Hultman CS, 2001, ANN PLAS SURG, V46, P242, DOI 10.1097/00000637-200103000-00007
   Miles WK, 2000, PLAST RECONSTR SURG, V105, P2387, DOI 10.1097/00006534-200006000-00012
NR 4
TC 2
Z9 2
U1 0
U2 4
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JUL
PY 2014
VL 80
IS 7
BP E202
EP E204
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA AK2WX
UT WOS:000338282000009
PM 24987886
DA 2026-07-24
ER
PT J
AU Rocco, G
   Martucci, N
   La Rocca, A
   La Manna, C
   De Luca, G
   Fazioli, F
   Mori, S
AF Rocco, Gaetano
   Martucci, Nicola
   La Rocca, Antonello
   La Manna, Carmine
   De Luca, Giuseppe
   Fazioli, Flavio
   Mori, Stefano
TI Postoperative Local Morbidity and the Use of Vacuum-Assisted Closure
   After Complex Chest Wall Reconstructions With New and Conventional
   Materials
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID COMBINATION; RESECTION; BIOMATERIALS; INFECTION; RADIATION; IMPLANTS;
   SURGERY; DEFECTS; CANCER
AB Background. New materials (NM) such as titanium plates, cryopreserved grafts, and acellular collagen matrices are being increasingly used for chest wall reconstruction as a result of improved incorporation while maintaining structural stability and reduced need for removal from infected areas. Direct comparisons between NM and conventional materials (CM) in terms of local morbidity and need for prosthesis removal are lacking.
   Methods. Between January 2005 and July 2013, 109 procedures were performed to remove chest wall tumors in 86 patients. Of these, 32 underwent complex chest wall reconstructions owing to either recurrence, defect extension (greater than 3 ribs or >100 cm(2)) or local conditions (ie, previous irradiation or infection). New materials and CM (ie, polytetrafluoroethylene and methyl methacrylate) were used in 17 (53%) and 15 (47%) patients, respectively. Of the 32 patients included in the high complexity group, 23 patients did not exhibit any postoperative complications (72%). However, 9 patients (28%) underwent both a first and a second reoperation after a median interval of 4 months from the first procedure (range, 7 days to 60 months). Vacuum-assisted closure (VAC) was instituted in all patients as a means to control sepsis and facilitate space obliteration with healthy tissue.
   Results. In 7 patients the reason for reintervention was local wound complications. In 4 of 7 patients, the prosthesis had to be removed (3 CM and 1 NM, 4.6% of the whole series; 12.5% in the high complexity group, 5.9% for NM and 20% for CM). The median time to complete chest wall healing after VAC in patients with local sepsis was 14 months (range, 5 to 60 months). All patients are currently alive and well except for 1 who died 11 months after complete chest wall healing as a result of dissemination of metastatic chondrosarcoma. At univariate analysis, predictors of overall and grade 2 or less morbidity according to the Common Terminology Criteria for Adverse Events version 4.0 were first (p = 0.038) and second (p = 0.015) redo operations. Conversely, patients with a body mass index of less than 25 kg/m(2) (p = 0.049) undergoing one (p = 0.032) or two reconstructions (p = 0.00047) with combined materials (p = 0.00029) were more likely to experience local wound complications and require VAC. On multiple regression analysis, redo operations (first, p = 0.032; second, p = 0.00047) and the use of combined (synthetic and biologic) materials (p = 0.0029) were confirmed to be related to an increased incidence of wound complications.
   Conclusions. Multiple redo operations after complex chest wall reconstruction performed with a combination of NM and CM may be associated with an increased incidence of local wound complications. Nevertheless, in these cases, the use of NM and VAC yielded a low rate (5.8% versus 20% with CM) of prosthesis removal while achieving complete wound healing. (C) 2014 by The Society of Thoracic Surgeons
C1 IRCCS, Fdn Pascale, Ist Nazl Tumori, Div Thorac Surg,Sect Orthoped, Naples, Italy.
   IRCCS, Fdn Pascale, Ist Nazl Tumori, Serv Reconstruct Surg, Naples, Italy.
C3 IRCCS Fondazione Pascale; Fondazione IRCCS Istituto Nazionale Tumori
   Milan; IRCCS Fondazione Pascale; Fondazione IRCCS Istituto Nazionale
   Tumori Milan
RP Rocco, G (通讯作者)，Via Terminio 1, I-83028 Avellino, Italy.
EM gaetano.rocco@btopenworld.com
RI ; Rocco, Gaetano/K-4801-2016
OI INVERNIZZI, GIORGIO/0000-0002-0409-8127; Rocco,
   Gaetano/0000-0003-4150-8604; FAZIOLI, FLAVIO/0000-0002-4308-1192
CR [Anonymous], COMM TERM CRIT ADV E
   Arnold PG, 1996, PLAST RECONSTR SURG, V98, P804, DOI 10.1097/00006534-199610000-00008
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   Rocco G, 2011, SEMIN THORAC CARDIOV, V23, P307, DOI 10.1053/j.semtcvs.2012.01.011
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   Saadi A, 2011, ANN THORAC SURG, V91, P1582, DOI 10.1016/j.athoracsur.2011.01.018
   Weyant MJ, 2006, ANN THORAC SURG, V81, P279, DOI 10.1016/j.athoracsur.2005.07.001
NR 21
TC 25
Z9 27
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD JUL
PY 2014
VL 98
IS 1
BP 291
EP 296
DI 10.1016/j.athoracsur.2014.04.022
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AK4ZF
UT WOS:000338432600072
PM 24857855
DA 2026-07-24
ER
PT J
AU Ren, HT
   Li, Y
AF Ren, Haitao
   Li, Yuan
TI Severe complications after negative pressure wound therapy in burned
   wounds: two case reports
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE negative pressure wound therapy; complication; burn sepsis; bleeding;
   drainage
ID MULTICENTER
AB We present two typical cases of severe complications (sepsis and hemorrhage) after negative pressure wound therapy (NPWT) in burned patients. Necrotic tissues in some deep burn wounds are difficult to judge correctly and remove thoroughly. An electrically burned blood vessel looks "intact" but can easily break. Necrotic tissue or injured blood vessels when using NPWT are dangerous, both for causing sepsis and hemorrhage. This is the first article that reports the severe complications of NPWT in burned patients. It is imperative to heed indications and avoid contraindications. Proper preparation of wound beds, close observation, and sufficient irrigation are also crucial to avoid these severe complications, and there is an urgent need to substitute the central vacuum system with the low-pressure system.
C1 [Ren, Haitao] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Burns & Wound Ctr, Hangzhou 310006, Zhejiang, Peoples R China.
   [Li, Yuan] Zhejiang Univ, Dept Ultrasound, Womens Hosp, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Li, Y (通讯作者)，Zhejiang Univ, Dept Ultrasound, Womens Hosp, Sch Med, Xue Shi Rd 1, Hangzhou 310006, Zhejiang, Peoples R China.
EM docliyuan@126.com
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
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   DELLINGER RP, 2013, CRIT CARE MED, V41, P580, DOI DOI 10.1097/CCM.0B013E31827E83AF
   Dumville JC, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010318.pub2
   GUPTA S, 2012, BASICS, P1
   Isaac AL, 2013, MED CLIN N AM, V97, P899, DOI 10.1016/j.mcna.2013.03.015
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   [No title captured]
NR 16
TC 10
Z9 18
U1 0
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2014
VL 10
BP 513
EP 516
DI 10.2147/TCRM.S66117
PG 4
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA AK4ZU
UT WOS:000338434200001
PM 25061310
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Santarpino, G
   Pollari, F
   Fischlein, TJ
AF Santarpino, Giuseppe
   Pollari, Francesco
   Fischlein, Theodor J.
TI Sternal closure following negative pressure wound therapy: a safe
   approach with a new titanium device
SO INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Mediastinal infection; Wound closure; Wound dehiscence; Wound infection
ID VACUUM-ASSISTED CLOSURE; SURGICAL-SITE INFECTIONS; LONG-TERM SURVIVAL;
   POSTOPERATIVE MEDIASTINITIS; RISK-FACTORS; DEEP; IMPACT; SURGERY;
   SYSTEM; COMPLICATIONS
AB Background: The application of negative pressure wound therapy (NPWT) in patients with deep wound infection after cardiac surgery has steadily increased worldwide. Following NPWT, in patients with concomitant sternal diastasis, preparation of the substernal structures for the sternal wires application is mandatory, with increased risk of severe complications, such as laceration of the right ventricle. The aim of this study is to present an innovative technique for sternal closure after NPWT, using the ASCS r System (ASCS atraumatic Sternum Closure System; KS Handelsvertretung Produktinovation, Bad Homburg, Germany).
   Methods: Between January 2009 and August 2012, 88 patients (mean age 64.2 +/- 12.4 years) with deep wound infection and sternal diastasis received NPWT; 16 of these patients (18.2%) underwent sternal closure after NPWT with ASCS r.
   Results: In all 16 cases, neither sub-sternal dissection nor placement of trans-or peristernal wires was necessary. No damage to the aortocoronary bypass and ventricular rupture occurred. Minimal post-operative bleeding from Redon drains (mean 40 +/- 10 ml) was present. At follow-up, deep wound infection and sternal diastasis did not occur.
   Conclusions: The ASCS r System combined with NPWT in patients with postoperative deep wound infection and sternal diastasis is a feasible and safe procedure. Because preparation of the substernal structures is not necessary, this device might prevent the occurrence of severe complications. Our experience, however, is limited and larger case series are necessary to fully evaluate this new and innovative technique.
C1 [Santarpino, Giuseppe; Pollari, Francesco; Fischlein, Theodor J.] Klinikum Nurnberg, Dept Cardiac Surg, Nurnberg, Germany.
C3 Klinikum Nurnberg
RP Santarpino, G (通讯作者)，Klinikum Sud, Klinikum Nurnberg, Dept Cardiac Surg, Breslauerstr 201, D-90471 Nurnberg, Germany.
EM g.santarpino@libero.it
RI Santarpino, Giuseppe/H-8678-2013; Pollari, Francesco/Q-4656-2016
OI Santarpino, Giuseppe/0000-0002-4913-9834; Pollari,
   Francesco/0000-0003-1729-532X
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   Schols RM, 2011, EUR J PLAST SURG, V34, P487, DOI 10.1007/s00238-011-0573-2
   Simek M, 2012, J CARDIOVASC SURG, V53, P113
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   Toumpoulis IK, 2005, CHEST, V127, P464, DOI 10.1378/chest.127.2.464
   Trick WE, 2000, J THORAC CARDIOV SUR, V119, P108, DOI 10.1016/S0022-5223(00)70224-8
   Zeitani J, 2013, EUR J CARDIO-THORAC, V43, pE144, DOI 10.1093/ejcts/ezt080
NR 25
TC 1
Z9 1
U1 0
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0391-3988
EI 1724-6040
J9 INT J ARTIF ORGANS
JI Int. J. Artif. Organs
PD MAR
PY 2014
VL 37
IS 3
BP 264
EP 269
DI 10.5301/ijao.5000295
PG 6
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA AK6CK
UT WOS:000338515100008
PM 24619892
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Raju, A
   Ooi, A
   Ong, YS
   Tan, BK
AF Raju, Ashvin
   Ooi, Adrian
   Ong, Yee Siang
   Tan, Bien Keem
TI Traumatic Lower Limb Injury and Microsurgical Free Flap Reconstruction
   with the Use of Negative Pressure Wound Therapy: Is Timing Crucial?
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article; Proceedings Paper
CT 7th Biennial Meeting of the World-Society-of-Reconstructive-Microsurgery
   (WSRM)
CY JUL 11-14, 2013
CL Chicago, IL
SP World Soc Reconstruct Microsurgery
DE negative pressure wound therapy; lower limb trauma; free flap
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY TRAUMA; SEVERE OPEN FRACTURES;
   SOFT-TISSUE COVERAGE; MANAGEMENT; OUTCOMES; DEFECTS; DISTAL; LEG
AB Background The timing of microsurgical free flap reconstruction for traumatic lower limb injury has been described as being optimal if conducted within the early period following injury, as higher rates of infection and flap loss were reported in the subsequent time period. However, for various reasons, reconstruction of these defects may be delayed. The aim of this article is to show that adequate debridement, negative pressure wound dressing, and sound reconstructive principles has led to increased free flap success rates regardless of the period between injury and reconstruction.
   Patients and Methods A 10-year retrospective single-center analysis of 50 traumatic lower limb cases from 2002 to 2012 was conducted. All patients had microsurgical free flap reconstruction after a period of negative pressure wound therapy (NPWT). Patient factors and reconstructive methods were analyzed and outcomes were compared.
   Results Mean interval between admission and free flap coverage was 17.5 days, and patients underwent NPWT for an average of 12 days (range, 1-35). Approximately 8% of patients had postoperative infections. Overall free flap success rate was 96%. Approximately 90% of patients were able to return to their premorbid footwear, with 96% able to mobilize independently approaching the end of their follow-up period.
   Conclusion Our study shows that traumatic lower limb reconstruction in the delayed period is no longer associated with high rates of flap failure. Improvements in microsurgery and the advent of NPWT have made timing no longer crucial in free flap coverage of traumatic lower limb injuries.
C1 [Raju, Ashvin] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117595, Singapore.
   [Ooi, Adrian; Ong, Yee Siang; Tan, Bien Keem] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 169608, Singapore.
C3 National University of Singapore; Singapore General Hospital
RP Ooi, A (通讯作者)，Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
EM dradrianooi@gmail.com
RI Ooi, Adrian/AAJ-8480-2021
OI Ooi, Adrian/0000-0001-7983-3635
CR BYRD HS, 1985, PLAST RECONSTR SURG, V76, P719, DOI 10.1097/00006534-198511000-00011
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NR 24
TC 32
Z9 36
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD JUL
PY 2014
VL 30
IS 6
BP 427
EP 430
DI 10.1055/s-0034-1371510
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA AK8OD
UT WOS:000338686300011
PM 24752744
DA 2026-07-24
ER
PT J
AU Achora, S
   Muliira, JK
   Thanka, AN
AF Achora, Susan
   Muliira, Joshua Kanaabi
   Thanka, Anita Nesa
TI Strategies to Promote Healing of Split Thickness Skin Grafts: An
   Integrative Review
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Review
DE dressings; evidence-based practice; fixation; nursing care; split
   thickness skin graft; wound care
ID WOUNDS; THERAPY; HEAD
AB Skin grafts are commonly used to promote healing of shallow wounds and burns, and wound care nurses play an important role in management of wounds treated with grafting. The purpose of this article was to review recent findings regarding strategies to promote healing of split-thickness skin grafts including topical phenytoin or platelet-rich plasma prior to graft application, fibrin sealant, or negative pressure wound therapy to stabilize a graft and to promote close adherence of the graft to the underlying wound bed and adjunctive therapies such as laser.
C1 [Achora, Susan; Muliira, Joshua Kanaabi; Thanka, Anita Nesa] Sultan Qaboos Univ, Dept Adult Hlth & Crit Care, Coll Nursing, Muscat, Oman.
C3 Sultan Qaboos University
RP Achora, S (通讯作者)，Sultan Qaboos Univ, Coll Nursing, POB 66, Al Khoud Muscat, Oman.
EM susanachora@ymail.com
RI MULIIRA, JOSHUA/ABC-7480-2020
OI MULIIRA, JOSHUA/0000-0003-3091-8835
CR Adams DC, 2005, DERMATOL SURG, V31, P1055
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   Al-Mutairi N, 2010, DERMATOL SURG, V36, P499, DOI 10.1111/j.1524-4725.2010.01477.x
   Anderson JJ, 2012, DIABET FOOT ANKLE, V3
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NR 32
TC 17
Z9 19
U1 0
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2014
VL 41
IS 4
BP 335
EP 339
DI 10.1097/WON.0000000000000035
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AK8WV
UT WOS:000338710300007
PM 24988511
DA 2026-07-24
ER
PT J
AU Chadi, SA
   Kidane, B
   Britto, K
   Brackstone, M
   Ott, MC
AF Chadi, Sami A.
   Kidane, Biniam
   Britto, Karen
   Brackstone, Muriel
   Ott, Michael C.
TI Incisional Negative Pressure Wound Therapy Decreases the Frequency of
   Postoperative Perineal Surgical Site Infections: A Cohort Study
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE Colon and rectal surgery; Abdominoperineal resection; Incisional
   negative pressure wound therapy; Wound closure
ID ABDOMINOPERINEAL RESECTION; RISK-FACTORS; PRIMARY CLOSURE;
   RECTAL-CANCER; CARCINOMA; COMPLICATIONS; PREVENTION; SURGERY;
   MANAGEMENT; EXCISION
AB BACKGROUND: Abdominoperineal resection is a procedure associated with high rates of perineal surgical site infections, causing distress to the patient, costs to the hospital system, and delays in further treatment.
   OBJECTIVE: The aim of this study was to investigate the role of incisional negative pressure wound therapy in decreasing the rates of perineal surgical site infection.
   DESIGN: This retrospective cohort study had a historical, consecutively sampled control group.
   SETTINGS: This study was conducted at a single-institution tertiary care academic institution.
   PATIENTS: All patients undergoing an abdominoperineal resection between 2008 and 2012 were assessed.
   INTERVENTIONS: Perineal incisional negative pressure wound therapy was applied to all patients following an abdominoperineal resection between 2010 and 2012 at 125 mmHg continuous suction for 5 days postoperatively.
   MAIN OUTCOME MEASURES: The development of a perineal surgical site infection within the first 30 days postoperatively was the primary outcome measured.
   RESULTS: Fifty-nine patients were included: 27 in the incisional negative pressure wound therapy group and 32 in the control group. A statistically lower proportion of perineal surgical site infections were detected in the incisional negative pressure wound therapy group than in the standard dressing group (15% vs 41%; p = 0.02). Both populations were similar in perioperative risk factors, with the exception of increased levels of blood urea nitrogen, a higher proportion of hypertensive patients, and a longer mean operative time in the incisional negative pressure wound therapy group. Additionally, an increased length of stay was observed in the incisional negative pressure wound therapy group (11 vs 8 days; p = 0.03). After adjusting for confounders, including the type of perineal dissection, incisional negative pressure wound therapy was found to be an independent predictor of not developing an surgical site infection (adjusted OR, 0.11; 95% CI, 0.04-0.66; p = 0.01).
   LIMITATIONS: The study's retrospective nature limits the results because of the risk of interpreter bias, although this was addressed in part by reviewing data in duplicate. We controlled for the potential for selection bias with our consecutive sampling model.
   CONCLUSIONS: Our study demonstrates a role for incisional negative pressure wound therapy in decreasing rates of perineal surgical site infection following abdominoperineal resection. Prospective randomized trials will be required to further investigate this intervention.
C1 [Chadi, Sami A.; Kidane, Biniam; Brackstone, Muriel; Ott, Michael C.] London Hlth Sci Ctr, Div Gen Surg, London, ON, Canada.
   [Chadi, Sami A.; Britto, Karen; Brackstone, Muriel; Ott, Michael C.] Western Univ, Schulich Sch Med & Dent, London, ON N6A 5W9, Canada.
C3 London Health Sciences Centre; Western University (University of Western
   Ontario)
RP Ott, MC (通讯作者)，Western Univ, Schulich Sch Med & Dent, London Hlth Sci Ctr, Victoria Campus,800 Commissioners Rd,E2-211, London, ON N6A 5W9, Canada.
EM michael.ott@lhsc.on.ca
RI Chadi, Sami/DWM-5165-2022
OI Kidane, Biniam/0000-0002-2982-2505; Ott, Michael/0000-0002-0816-7089
CR Artioukh DY, 2007, COLORECTAL DIS, V9, P362, DOI 10.1111/j.1463-1318.2006.01159.x
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   Wiatrek Rebecca L, 2008, Clin Colon Rectal Surg, V21, P76, DOI 10.1055/s-2008-1055325
NR 23
TC 55
Z9 74
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD AUG
PY 2014
VL 57
IS 8
BP 999
EP 1006
DI 10.1097/DCR.0000000000000161
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA AL6KO
UT WOS:000339241500013
PM 25003295
DA 2026-07-24
ER
PT J
AU Parcells, AL
   Abernathie, B
   Datiashvili, R
AF Parcells, Alexis Lanteri
   Abernathie, Brenon
   Datiashvili, Ramazi
TI The Use of Urinary Bladder Matrix in the Treatment of Complicated Open
   Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE urinary bladder matrix; complicated wounds; vacuum-assisted closure
ID SMALL-INTESTINAL SUBMUCOSA; SOFT-TISSUE REPAIR; EXTRACELLULAR-MATRIX;
   DOG-MODEL; SCAFFOLDS; DEGRADATION; THERAPY; REGENERATION; BIOSCAFFOLD
AB Background. Management of complicated open wounds represents a challenge when reconstructive options are not applicable. Urinary bladder matrix (UBM) provides a biocompatible material that allows inductive tissue remodeling. Methods. The use of urinary bladder matrix in the treatment of 5 patients with complicated open wounds that failed to heal with conventional therapy is presented. Results. A 3-year old male sustained a second-degree oil burn measuring 8 cm x 4 cm to his dorsal forearm; UBM was applied weekly and the wound epithelialized in 3 weeks. A 52-year old male sustained massive second and third degree burns to his leg after a fire; UBM was applied weekly and the wound epithelialized in 28 weeks. A 61-year old female sustained a severe crushing injury to her right knee. A gastrocnemius muscle transfer and rectus abdominus muscle free flap transfer both failed, then UBM and vacuum-assisted closure therapy were applied and the wound epithelialized in 24 weeks. A 54-year old,female underwent a breast mastectomy and immediate reconstruction with pedicled transverse rectus abdominus flap. The patient developed partial necrosis and the wound was managed with UBM and vacuum-assisted closure therapy. The wound epithelialized in 12 weeks. A 36-year old female sustained severe degloving injuries to both hands with exposed metacarpals. Weekly application of UBM provided tissue remodeling over the bones, which allowed successful skin grafting and closure. Conclusions. These experiences show UBM to be an effective method in management of complicated open wounds in select cases. Further studies need to be implemented to confirm this conclusion.
C1 [Parcells, Alexis Lanteri; Abernathie, Brenon; Datiashvili, Ramazi] Rutgers Biomed & Hlth Sci, Dept Surg, Div Plast Surg, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Parcells, AL (通讯作者)，Rutgers Biomed & Hlth Sci, Dept Surg, Div Plast Surg, 140 East Bergen St Suite 1620, Newark, NJ 07103 USA.
EM lanteral@njms.rutgers.edu
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NR 24
TC 30
Z9 31
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2014
VL 26
IS 7
BP 189
EP 196
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AM0NA
UT WOS:000339541100002
PM 25860538
DA 2026-07-24
ER
PT J
AU Bezjian, M
   Wellehan, JFX
   Walsh, MT
   Anderson, E
   Jacobson, E
AF Bezjian, Marisa
   Wellehan, James F. X., Jr.
   Walsh, Michael T.
   Anderson, Eric
   Jacobson, Elliott
TI MANAGEMENT OF WOUNDS IN A LOGGERHEAD SEA TURTLE (CARETTA CARETTA)
   CAUSED BY TRAUMATIC BYCATCH INJURY FROM THE SPINES OF A SPOTTED EAGLE
   RAY (AETOBATUS NARINARI)
SO JOURNAL OF ZOO AND WILDLIFE MEDICINE
LA English
DT Article
DE Aetobatus narinari; bycatch; Caretta caretta; loggerhead turtle;
   stingray spine; trawl net
ID RISK
AB A subadult female loggerhead sea turtle (Caretta caretta) was caught in a trawl net off the west coast of Florida with a spotted eagle ray (Aetobatus narinari) spine lodged in the left stifle. Surgical removal of the spine was performed and antibiotic treatment was initiated. Four weeks later, endoscopy revealed a second spine entering an intestinal lumen. The fistulous tract of the left prefemoral fossa was surgically excised and the intestinal perforation was repaired. Dehiscence occurred and a vacuum-assisted closure (VAC) system was used on the wound for approximately 18 days to help reduce infection and increase the rate of healing. The left stifle wound was treated to heal by second intention. The turtle remained in rehabilitation for 19 mo before being released off the west coast of Florida. This case describes stingray envenomation injuries as a complex and potentially life-threatening bycatch effect to sea turtles caught in trawl nets.
C1 [Bezjian, Marisa; Wellehan, James F. X., Jr.; Jacobson, Elliott] Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA.
   [Walsh, Michael T.] Univ Florida, Coll Vet Med, Dept Large Anim Clin Sci, Gainesville, FL 32610 USA.
   [Anderson, Eric] Mote Marine Lab & Aquarium, Sarasota, FL 34236 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; Mote Marine
   Laboratory & Aquarium
RP Bezjian, M (通讯作者)，Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, 2015 SW 16th Ave, Gainesville, FL 32610 USA.
EM marisa.bezjian@gmail.com
RI Wellehan, Jim/B-2021-2008
OI Wellehan, Jim/0000-0001-5692-6134
CR Bolten AB, 2011, FRONT ECOL ENVIRON, V9, P295, DOI 10.1890/090126
   Finkbeiner EM, 2011, BIOL CONSERV, V144, P2719
   Fowler M, 2012, FOWLERS ZOO WILD ANI, V7, P170
   Griffiths SP, 2006, MAR FRESHWATER RES, V57, P395, DOI 10.1071/MF05190
   ISIS, 2002, REF RANG PHYS VAL CA
   JACOBSON E, ESTABLISHING PLASMA
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   Marine Turtle Specialist Group, 1996, IUCN 2013
   Sasso CR, 2006, FISH RES, V81, P86, DOI 10.1016/j.fishres.2006.05.016
   Sasso CR, 2011, HERPETOL CONSERV BIO, V6, P443
   United States Fish and Wildlife Service, 2011, DETERMINATION 9 DIST, V76, P58868
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NR 14
TC 4
Z9 6
U1 0
U2 29
PU AMER ASSOC ZOO VETERINARIANS
PI YULEE
PA 581705 WHITE OAK ROAD, YULEE, FL 32097 USA
SN 1042-7260
EI 1937-2825
J9 J ZOO WILDLIFE MED
JI J. Zoo Wildl. Med.
PD JUN
PY 2014
VL 45
IS 2
BP 428
EP 432
DI 10.1638/2013-0178R.1
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA AM2AF
UT WOS:000339649800035
PM 25000714
DA 2026-07-24
ER
PT J
AU Li, ZH
   Yu, AX
AF Li, Zonghuan
   Yu, Aixi
TI Complications of negative pressure wound therapy: A mini review
SO WOUND REPAIR AND REGENERATION
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; RIGID BARRIER; MANAGEMENT; ULCERS; DISC
AB Negative pressure wound therapy, with its wide indications and narrow contraindications, has been widely used for various complicated wounds. Despite its excellent properties in promoting wound healing, there are sporadic but increasing reports on the complications. These complications included bleeding, infection, pain, rupture of the heart, and death in the short term. When used for the long term, the therapy may decrease life quality, increase anxiety, and lead to malnutrition. In this review, we briefly summarize the complications of negative pressure wound therapy.
C1 [Li, Zonghuan; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Microorthoped, Wuhan 430072, Hubei, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, 169 Donghu Rd, Wuchang Dist Wuhan 430071, Hubei, Peoples R China.
EM yuaixi666@163.com
FU National Science Funds of China [81171713]
FX This work was financed by National Science Funds of China (Project code:
   81171713).
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   [Anonymous], NEG PRESS WOUND THER
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NR 40
TC 45
Z9 55
U1 2
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2014
VL 22
IS 4
BP 457
EP 461
DI 10.1111/wrr.12190
PG 5
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA AM2DG
UT WOS:000339658700005
PM 24852446
DA 2026-07-24
ER
PT J
AU Yang, SL
   Han, R
   Liu, Y
   Hu, LY
   Li, XL
   Zhu, LY
AF Yang, Shao-Ling
   Han, Rui
   Liu, Yu
   Hu, Li-Ye
   Li, Xiao-Ling
   Zhu, Lv-Yun
TI Negative pressure wound therapy is associated with up-regulation of bFGF
   and ERK1/2 in human diabetic foot wounds
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID FIBROBLAST-GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; PROLIFERATION;
   MULTICENTER; IMPAIRMENT; MECHANISMS; CELLS
AB Chronic foot wounds are a leading cause of morbidity and hospitalization for patients with diabetes. Negative pressure wound therapy (NPWT) is known to promote healing of diabetic foot wounds, but the underlying molecular mechanisms remain elusive. We propose to gain molecular insights into the wound healing promoting signals underlying the effects of NPWT on diabetic foot wounds in humans. We assessed 30 patients with diabetic foot ulcers. Of these cases, 15 were treated with NPWT, while 15 patients were treated with traditional gauze therapy. Granulated tissue was harvested before and after treatment in both patient groups and histologically analyzed with hematoxylin & eosin as well as Masson's trichrome staining methods. Immunohistochemistry and Western blot analysis was performed to evaluate expression of basic fibroblast growth factor (bFGF) and extracellular signal-regulated kinase (ERK) 1/2, previously associated with promoting cellular growth and/or wound healing. Unlike controls, the wounds in the NPWT-treated diabetic patients developed characteristic features of granulated tissue with increased collagen deposition. Immunohistochemical analysis also revealed an increase in bFGF levels in NPWT-treated patients. Western blot analysis further showed a significant up-regulation of bFGF and phosphorylated ERK1/2 protein levels in the NPWT-treated diabetic patients vs. controls. Our studies reveal that NPWT is associated with an up-regulation of bFGF and ERK1/2 signaling, which may be involved in promoting the NPWT-mediated wound healing response.
C1 [Yang, Shao-Ling; Hu, Li-Ye; Li, Xiao-Ling; Zhu, Lv-Yun] PLA, Peace Hosp, Dept Endocrinol, Shijiazhuang 050082, Hebei, Peoples R China.
   [Han, Rui] Hebei Med Univ, Dept Neurol, Affiliated Hosp 1, Shijiazhuang, Hebei, Peoples R China.
   [Liu, Yu] Hebei Med Univ, Dept Biochem & Mol Biol, Tradit Chinese Med Coll, Lab Med Biotechnol Hebei Prov, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Zhu, LY (通讯作者)，PLA, Peace Hosp, Dept Endocrinol, 398 Zhongshan Rd, Shijiazhuang 050082, Hebei, Peoples R China.
EM yshling9@126.com
RI ; lvyun, zhu/Z-4736-2019
OI Liu, Yu/0000-0001-6268-3511; 
FU Hebei Province Natural Science Foundation of P.R. China [C2009001352]
FX This research was supported by the Hebei Province Natural Science
   Foundation of P.R. China (No. C2009001352). The authors wish to thank
   Professor Chun-Fang Zhao (Department of Embryology, Hebei Medical
   University) for her technical assistance.
CR [Anonymous], 2012, EPLASTY
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NR 37
TC 36
Z9 42
U1 0
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2014
VL 22
IS 4
BP 548
EP 554
DI 10.1111/wrr.12195
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA AM2DG
UT WOS:000339658700017
PM 24809625
DA 2026-07-24
ER
PT J
AU Tarzia, V
   Carrozzini, M
   Bortolussi, G
   Buratto, E
   Bejko, J
   Comisso, M
   Mescola, V
   Penzo, V
   Guarino, M
   De Franceschi, M
   Pagnin, C
   Castoro, M
   Guglielmi, C
   Testolin, L
   Bottio, T
   Gerosa, G
AF Tarzia, Vincenzo
   Carrozzini, Massimiliano
   Bortolussi, Giacomo
   Buratto, Edward
   Bejko, Jonida
   Comisso, Marina
   Mescola, Valentina
   Penzo, Valentina
   Guarino, Mauro
   De Franceschi, Marco
   Pagnin, Chiara
   Castoro, Massimo
   Guglielmi, Cosimo
   Testolin, Luca
   Bottio, Tomaso
   Gerosa, Gino
TI Impact of vacuum-assisted closure therapy on outcomes of sternal wound
   dehiscenceaEuro
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 27th Annual Meeting of the
   European-Association-for-Cardio-Thoracic-Surgery (EACTS)
CY OCT 05-09, 2013
CL Vienna, AUSTRIA
SP European Assoc Cardio Thorac Surg
DE Vacuum-assisted closure therapy; Sternal wound dehiscence;
   Mediastinitis; Sternal wound complication; Surgical site infection; Cost
   analysis
ID POSTSTERNOTOMY MEDIASTINITIS; COMPLICATIONS; INFECTION; DEFORMATIONS;
   STERNOTOMY
AB OBJECTIVES: Sternal wound dehiscence (SWD) after cardiac surgery is a rare but serious condition associated with considerable costs and morbidity. We sought to evaluate the results of the introduction of vacuum-assisted closure (VAC) therapy in the management of sternal wound dehiscence, compared with those of previous conventional treatments.
   METHODS: We retrospectively collected 7148 patients who underwent cardiac surgery at our institution between January 2002 and June 2012. A total of 152 (2.1%) patients had a sternal wound dehiscence: 107 were treated with conventional treatments (Group A) and 45 were managed with VAC therapy (Group B). Patients were stratified according to preoperative risk factors and type of sternal wound dehiscence (superficial or deep; infected or not) and compared by means of a propensity-matched analysis. A cost analysis was also performed.
   RESULTS: Forty-five patients of each group matched for all preoperative risk factors and type of sternal wound dehiscence. SWD-related mortality rate was significantly lower in Group B (11 vs 0%; P = 0.05). Incidence of mediastinitis (P < 0.0001), sepsis (P = 0.04), delayed SWD infection (P = 0.05), other complication (P = 0.05), surgical sternal revision (P = 0.04) and surgical superficial revision (P < 0.0001) were all significantly lower in Group B. Mean patient cost was 31 106a,not sign in Group A and 24 383a,not sign in Group B, thus achieving a mean saving of 6723a,not sign per patient.
   CONCLUSIONS: In our experience, the use of VAC therapy for the management of SWD was considerably effective in decreasing mortality (SWD related), incidence of complications and need for surgical procedures; thus, leading to a significant reduction of costs.
C1 [Tarzia, Vincenzo; Carrozzini, Massimiliano; Bortolussi, Giacomo; Buratto, Edward; Bejko, Jonida; Comisso, Marina; Mescola, Valentina; Penzo, Valentina; Guarino, Mauro; De Franceschi, Marco; Pagnin, Chiara; Guglielmi, Cosimo; Testolin, Luca; Bottio, Tomaso; Gerosa, Gino] Univ Padua, Cardiac Surg Unit, Dept Cardiac Thorac & Vasc Sci, I-35128 Padua, Italy.
   [Castoro, Massimo] Padova Univ Hosp, Hlth Technol Assessment Unit, Padua, Italy.
C3 University of Padua; University of Padua; Azienda Ospedaliera -
   Universita di Padova
RP Tarzia, V (通讯作者)，Univ Padua, Policlin Univ, Cardiac Surg Unit, Dept Cardiac Thorac & Vasc Sci,Ctr V Gallucci, Via Giustiniani 2, I-35128 Padua, Italy.
EM v.tarzia@gmail.com
RI Tarzia, Vincenzo/AAC-2097-2019; Bortolussi, Giacomo/AAM-3278-2020;
   Buratto, Edward/AAW-9469-2020; Carrozzini, Massimiliano/M-7138-2018;
   Gerosa, Gino/M-8106-2014; BOTTIO, TOMASO/AAQ-9040-2020
OI Tarzia, Vincenzo/0000-0003-2360-2031; Bortolussi,
   Giacomo/0000-0003-3640-1597; Buratto, Edward/0000-0002-8330-3917;
   Carrozzini, Massimiliano/0000-0001-5506-0201; Gerosa,
   Gino/0000-0002-6261-699X; BOTTIO, TOMASO/0000-0001-7299-2983
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NR 16
TC 32
Z9 39
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUL
PY 2014
VL 19
IS 1
BP 70
EP 74
DI 10.1093/icvts/ivu101
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AM2HB
UT WOS:000339669900019
PM 24722512
OA Bronze
DA 2026-07-24
ER
PT J
AU Kawajiri, H
   Aeba, R
   Takaki, H
   Yozu, R
   Iwata, S
AF Kawajiri, Hiroyuki
   Aeba, Ryo
   Takaki, Hidenobu
   Yozu, Ryohei
   Iwata, Satoshi
TI Negative pressure therapy for post-sternotomy wound infections in young
   children
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Wound infection; Sternotomy; Congenital heart disease
ID VACUUM-ASSISTED CLOSURE; PEDIATRIC CARDIAC-SURGERY; MUSCLE FLAP;
   POSTOPERATIVE MEDIASTINITIS; RISK-FACTORS; EXPERIENCE
AB OBJECTIVES: Post-sternotomy wound infection remains a significant morbidity in congenital and paediatric cardiac surgery. However, the techniques used for this complication in children are not optimal in terms of mortality, morbidity and the use of medical resources. Negative pressure therapy is an effective modality in the treatment in adults, but reports of its use in children are limited. This study evaluated the use of negative pressure therapy in young children for post-sternotomy wound infections.
   METHODS: From October 2004 to June 2012, 15 consecutive cases of post-sternotomy wound infections in patients a parts per thousand currency sign6 years of age were managed with negative pressure therapy, and these patients were followed up for a parts per thousand yen12 months after wound closure. The median Aristotle comprehensive complexity score was 9.9 +/- 4.0. The infection was identified at a median of 16 days after surgery, and the procedure was performed within 24 h of diagnosis. No additional surgical procedures were applied.
   RESULTS: No cases of hospital mortality or second surgery for infection control occurred. The median duration until wound closure was 25 days (range: 5-92 days). Further, no patient showed sternal instability at treatment termination. During the mean follow-up period of 45.8 +/- 31.3 months after wound closure, no admission occurred for infection recurrence. According to a multivariable analysis, the infection depth and patient weight significantly lengthened treatment duration (P = 0.008 and 0.046, respectively).
   CONCLUSIONS: Negative pressure therapy is an effective treatment modality for wound infections in paediatric cardiac surgery and results in low morbidity, mortality and medical resource use.
C1 [Kawajiri, Hiroyuki; Aeba, Ryo; Takaki, Hidenobu; Yozu, Ryohei] Keio Univ, Div Cardiovasc Surg, Tokyo 1608582, Japan.
   [Iwata, Satoshi] Keio Univ, Ctr Infect Dis & Infect Control, Tokyo 1608582, Japan.
C3 Keio University; Keio University
RP Aeba, R (通讯作者)，Keio Univ, Div Cardiovasc Surg, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM aebajp@gmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BACKER CL, 1994, ANN THORAC SURG, V57, P797, DOI 10.1016/0003-4975(94)90179-1
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NR 23
TC 6
Z9 9
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUL
PY 2014
VL 19
IS 1
BP 102
EP 106
DI 10.1093/icvts/ivu050
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AM2HB
UT WOS:000339669900026
PM 24648466
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Liu, YN
   Yan, Y
   Li, SJ
   Liu, H
   Wu, Q
   Zhang, LJ
   Yang, Y
   Chen, JF
AF Liu, Yi-Nan
   Yan, Yan
   Li, Shi-Jie
   Liu, Hui
   Wu, Qi
   Zhang, Li-Jian
   Yang, Yue
   Chen, Jin-Feng
TI Reliable management of post-esophagectomy anastomotic fistula with
   endoscopic trans-fistula negative pressure drainage
SO WORLD JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE anastomotic fistula; esophagectomy; endoscopic management
ID VACUUM-ASSISTED CLOSURE; LEAKAGE
AB Background: A gastroesophageal anastomotic fistula remains a potentially life-threatening post-esophagectomy complication. To promote fistula closure, we developed a modified endoscopic method of trans-fistula drainage with persistent negative pressure. In this study, we aimed to evaluate the efficacy of this endoscopic therapy.
   Methods: Between June and November 2013, five male patients with post-surgical esophageal leakages who had undergone trans-fistula drainage therapy were treated with the modified endoscopic trans-fistula negative pressure drainage (E-TNPD) method. We placed a nasogastric silicone tube into the paraesophageal cavity through the fistula and accomplished drainage of the infected effusion with continuous negative pressure, resulting in shrinkage of the para-anastomotic cavity and eventual fistula closure. We withdrew the trans-fistula drainage when there were no signs of leakage, as confirmed by esophagography. Final closure was confirmed by esophagography before the patient was allowed to begin oral intake.
   Results: E-TNPD was successful in all five patients. The median duration of drainage until tube removal was 34 days (range: 18 to 81 days). The duration for Cases 1 to 4 was 18 to 28 days. Case 5 suffered from multiple separate leaks at the anastomotic site and the gastric conduit. Complete restoration was achieved in 81 days for this patient. We found that in general, the earlier that trans-fistula drainage was established, the shorter the duration of hospitalization until complete defect closure.
   Conclusions: E-TNPD provided reliable and convenient management of post-surgical gastroesophageal anastomotic fistula and esophageal perforation. This method promoted fistula closure and prevented unnecessary repeated endoscopic examinations, extra equipment and expense.
C1 [Liu, Yi-Nan; Zhang, Li-Jian; Yang, Yue; Chen, Jin-Feng] Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 2, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China.
   [Yan, Yan; Li, Shi-Jie; Wu, Qi] Peking Univ, Canc Hosp & Inst, Endoscopy Ctr, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China.
   [Liu, Hui] Beijing Pharma & Biotech Ctr, Beijing 100193, Peoples R China.
C3 Peking University; Peking University
RP Chen, JF (通讯作者)，Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 2, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China.
EM chengjinfeng123@163.com
RI Zhang, Lijian/OUK-0816-2025
FU Beijing Science New Star Plan [Z11111005450000]; National Nature Science
   Foundation of China [81101598]
FX This study was supported by the Beijing Science New Star Plan
   (Z11111005450000) and the National Nature Science Foundation of China
   (81101598).
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NR 14
TC 14
Z9 16
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7819
J9 WORLD J SURG ONCOL
JI World J. Surg. Oncol.
PD JUL 30
PY 2014
VL 12
AR 240
DI 10.1186/1477-7819-12-240
PG 6
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA AM4PI
UT WOS:000339837000001
PM 25078091
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhang, CW
   Liu, DL
   Liang, Z
   Liu, F
   Lin, HB
   Guo, ZD
AF Zhang, Chenwei
   Liu, Dalie
   Liang, Zhi
   Liu, Fei
   Lin, Haibo
   Guo, Zhengdong
TI Repair of Refractory Wounds Through Grafting of Artificial Dermis and
   Autologous Epidermis Aided by Vacuum-Assisted Closure
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE VAC; Artificial dermis; Wound; Autologous epidermis
ID NEGATIVE-PRESSURE THERAPY; TISSUE DEFECTS; RECONSTRUCTION; FOUNDATION;
   DRESSINGS; INTEGRA; STATE; SOFT
AB This study aimed to investigate the clinical efficacy of vacuum-assisted closure (VAC) combined with grafting of artificial dermis and autologous epidermis in the repair of refractory wounds.
   Patients with refractory wounds underwent debridement. Then the VAC device was used to culture wound granulation tissue. After the wound granulation tissue began to grow, artificial dermis was grafted on the wounds with VAC treatment. Then autologous epidermis was grafted on the artificial dermis to repair the wounds after survival of the artificial epidermis. The study mainly observed length of the hospital stay, survival of the artificial dermis, time required for culture of the granulation tissue using VAC before grafting of the artificial dermis, survival time of the artificial dermis, survival conditions of the autologous epidermis, influence on functions of a healed wound at a functional part, healing conditions of donor sites, and recurrence conditions of the wounds.
   Healing was successful for 22 patients (95.7%), but treatment failed for 1 child. The 22 patients were followed up for 6 to 24 months. According to follow-up findings, the skin grafts had good color and a soft texture. They were wear resistant and posed no influence on function. The appearance of the final results was the same as that of the full-thickness skin graft. Mild or no pigmentation and no scar formation occurred at the donor sites, and the wounds did not recur.
   Vacuum-assisted closure combined with grafting of artificial dermis and autologous epidermis is an effective means for repairing refractory wounds and is worth clinical popularizing and application.
   This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.spinger.com/00266.
C1 [Zhang, Chenwei; Liu, Dalie] Southern Med Univ, Zhujiang Hosp, Dept Plast Surg, Guangzhou 510282, Guangdong, Peoples R China.
   [Zhang, Chenwei; Liang, Zhi; Liu, Fei; Lin, Haibo; Guo, Zhengdong] Guangdong Med Coll, Dept Plast Surg, Affiliated Nanshan Hosp, Shenzhen 518052, Peoples R China.
C3 Southern Medical University - China; Guangdong Medical University
RP Liu, DL (通讯作者)，Southern Med Univ, Zhujiang Hosp, Dept Plast Surg, Guangzhou 510282, Guangdong, Peoples R China.
EM dalieliu2008@126.com
RI Liu, Fei/AAW-6037-2021
FU Shenzhen Science and Technology Program [201203226]
FX The research was supported by the Shenzhen Science and Technology
   Program (No. 201203226).
CR [Anonymous], BR J PLAST SURG
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   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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NR 22
TC 9
Z9 12
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD AUG
PY 2014
VL 38
IS 4
BP 727
EP 732
DI 10.1007/s00266-014-0341-3
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AM5AE
UT WOS:000339866500015
PM 24902915
DA 2026-07-24
ER
PT J
AU Zheng, ZL
   Morykwas, M
   Campbell, D
   McGee, M
   Hollingsworth, C
   Adams, F
   Mays, J
   Tatter, S
   Argenta, L
AF Zheng, Zhen-Lin
   Morykwas, Michael
   Campbell, Douglas
   McGee, Maria
   Hollingsworth, Charlotte
   Adams, Farren
   Mays, Jennifer
   Tatter, Stephen
   Argenta, Louis
TI Mechanical Tissue Resuscitation at the Site of Traumatic Brain Injuries
   Reduces the Volume of Injury and Hemorrhage in a Swine Model
SO NEUROSURGERY
LA English
DT Article
DE Magnetic resonance imaging analysis; Mechanical tissue resuscitation;
   Subatmospheric pressure treatment; Swine model; Traumatic brain injury
ID VACUUM-ASSISTED CLOSURE; CONTROLLED CORTICAL IMPACT; PERISTERNAL
   THORACIC WALL; PRESSURE WOUND THERAPY; BLOOD-FLOW; EDEMA;
   PATHOPHYSIOLOGY; FOOTBALL; RAT
AB BACKGROUND: Traumatic brain injuries (TBIs) continue to be a devastating problem with limited treatment options. Previous research applying controlled vacuum to TBI in a rat model resulted in smaller injuries and more rapid recovery.
   OBJECTIVE: To examine the effects of the application of a controlled vacuum (mechanical tissue resuscitation) to TBI in a large-animal model. The magnitude of vacuum, length of application, and length of delay between injury and the application of mechanical tissue resuscitation were investigated.
   METHODS: Localized, controlled cortical injuries were created in swine. Vacuums of -50 and -100 mm Hg were compared. Mechanical tissue resuscitation for 3 or 5 days was compared. Delays of 0, 3, or 6 hours between the creation of the TBI and the initiation of mechanical tissue resuscitation were examined. Analysis included histological assessments, computed tomographic perfusion, and magnetic resonance imaging (T2, proton magnetic spectra).
   RESULTS: A -100 mm Hg vacuum resulted in significantly smaller mean contused brain and hemorrhage volumes compared with -50 mm Hg and controls. Magnetic resonance spectra of treated animals returned to near baseline values. All 10 animals with 5-day mechanical tissue resuscitation treatment survived. Three of 6 animals treated for 3 days died after the discontinuation of treatment. A 3-hour delay resulted in similar results as immediate treatment. A 6-hour delay produced significant, but lesser responses.
   CONCLUSION: Application of mechanical tissue resuscitation to TBI was efficacious in the large-animal model. Application of -100 mm Hg for 5 days resulted in significantly improved outcomes. Delays of up to 3 hours between injury and the initiation of treatment did not diminish the efficacy of the mechanical tissue resuscitation treatment.
C1 [Zheng, Zhen-Lin; Morykwas, Michael; McGee, Maria; Hollingsworth, Charlotte; Adams, Farren; Mays, Jennifer; Argenta, Louis] Wake Forest Univ Hlth Sci, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
   [Campbell, Douglas] Wake Forest Univ Hlth Sci, Dept Gen Surg, Winston Salem, NC 27157 USA.
   [Tatter, Stephen] Wake Forest Univ Hlth Sci, Dept Neurosurg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest University School of Medicine; Wake
   Forest University; Wake Forest University School of Medicine; Wake
   Forest University; Wake Forest University School of Medicine
RP Argenta, L (通讯作者)，Wake Forest Univ Hlth Sci, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM largenta@wakehealth.edu
RI ; Tatter, Stephen/AAD-6524-2021
OI Morykwas, Michael/0009-0001-5547-5172; Tatter,
   Stephen/0000-0002-1063-0431
FU US Army [W81XWH-09-1-0437]; Cheek Research Endowment of Wake Forest
   University
FX This study was supported by grant W81XWH-09-1-0437 from the US Army and
   by the Cheek Research Endowment of the Wake Forest University. A patent
   covering the technique described in this article has been issued to some
   of the authors (LA, MM, ST) and Wake Forest Health Services. The authors
   have no personal, financial, or institutional interest in any of the
   drugs, materials, or devices described in this article.
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NR 33
TC 9
Z9 11
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0148-396X
EI 1524-4040
J9 NEUROSURGERY
JI Neurosurgery
PD AUG
PY 2014
VL 75
IS 2
BP 152
EP 161
DI 10.1227/NEU.0000000000000341
PG 10
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA AM8PE
UT WOS:000340138400030
PM 24618796
DA 2026-07-24
ER
PT J
AU Fleming, ME
   O'Daniel, A
   Bharmal, H
   Valerio, I
AF Fleming, Mark E.
   O'Daniel, Anthony
   Bharmal, Husain
   Valerio, Ian
TI Application of the Orthoplastic Reconstructive Ladder to Preserve Lower
   Extremity Amputation Length
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE amputation; soft tissue; length; energy; salvage
ID EXTERNAL TISSUE EXPANDER; EXTRACELLULAR-MATRIX; FREE FLAPS; TRAUMATIC
   AMPUTATIONS; ENERGY-EXPENDITURE; SKIN-GRAFTS; STUMPS; MANAGEMENT;
   AMPUTEES; MODEL
AB Background: A primary goal in traumatic lower extremity amputation management is preservation of limb length. Energy expenditure during ambulation directly correlates with residual limb length, preserved limb segments, and stable joint preservation. An additional factor affecting limb function includes achieving adequate residual limb soft tissue coverage. This report describes techniques for achieving a stable soft tissue envelope to facilitate limb length and joint preservation.
   Methods: A series of traumatic amputation cases with inadequate soft tissue coverage are reviewed. Concepts from the reconstructive surgery ladder were used to achieve residual limb soft tissue coverage and to preserve lower extremity amputation length.
   Results: Soft tissue coverage was accomplished through a series of methods including delayed primary closure with assistance from an external tissue expander, use of acellular dermal regenerative templates combined with split-thickness skin grafting and negative-pressure wound therapy, use of biologic scaffolds such as extracellular porcine urinary bladder matrix combined with delayed skin grafting, and local pedicle flaps or adjacent tissue rearrangements and free tissue transfers.
   Conclusions: The preservation of residual limb length in lower extremity amputations is crucial to optimize prosthetic fitting and to obtain the maximal functional outcome. A series of cases are presented that outline soft tissue coverage options for preserving maximal residual limb length. Applying various concepts from the reconstructive ladder may allow for viable soft tissue coverage to maximize functional outcome.
C1 [Fleming, Mark E.; O'Daniel, Anthony; Bharmal, Husain] Walter Reed Natl Mil Med Ctr, Dept Orthopaed, Bethesda, MD 20889 USA.
   [Fleming, Mark E.; Valerio, Ian] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Valerio, Ian] Walter Reed Natl Mil Med Ctr, Plast & Reconstruct Serv, Bethesda, MD USA.
C3 Walter Reed National Military Medical Center; Uniformed Services
   University of the Health Sciences - USA; Walter Reed National Military
   Medical Center
RP Fleming, ME (通讯作者)，Walter Reed Natl Mil Med Ctr, Dept Orthopaed, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM drmefleming@msn.com
RI Fleming, Mark/HJA-3208-2022; Valerio, Ian/F-9161-2017
OI Fleming, Mark/0000-0002-4753-2632; 
CR Beattie AJ, 2009, TISSUE ENG PT A, V15, P1119, DOI 10.1089/ten.tea.2008.0162
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NR 40
TC 27
Z9 36
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD AUG
PY 2014
VL 73
IS 2
BP 183
EP 189
DI 10.1097/SAP.0b013e3182a638d8
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AM8RH
UT WOS:000340144200015
PM 24691339
DA 2026-07-24
ER
PT J
AU Shin, SJ
   Han, D
   Song, H
   Jang, YJ
   Park, DH
   Park, MC
AF Shin, Seung Jun
   Han, DaeHee
   Song, Hyunsuk
   Jang, Yu Jin
   Park, Dong Ha
   Park, Myong Chul
TI Continuous High-Pressure Negative Suction Drain: New Powerful Tool for
   Closed Wound Management: Clinical Experience
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Seroma; wall suction; continuous high-pressure negative suction drain
ID VACUUM-ASSISTED CLOSURE; THERAPY; SKIN
AB Background: Although various reconstructive flap surgeries have been successfully performed, there still are difficult wound complications, such as seroma formation, wound margin necrosis, delayed wound healing, and even flap failures. The negative-pressure wound therapy has been described in detail in the literature to assist open chronic/complex wound closure in reconstructive surgery. However, the negative-pressure wound therapy was difficult to be applied under the incisional closed wounds.
   Methods: A total of 23 patients underwent the various reconstructive flap surgeries with continuous high-pressure negative suction drain. Instead of using regular suction units, Barovac (50-90 mm Hg, Sewoon Medical, Seoul, Republic of Korea) drainage tubes were connected to the wall suction unit, providing continuous high-powered negative pressure. In addition, continuous subatmospheric suction pressure (100-300 mm Hg) was applied. Outcome of the measures was obtained from the incidence of seroma, volume of postoperative drainage, hospitalization period, and incidence of other typical wound complications. Dead space was evaluated postoperatively with ultrasonography.
   Results: Using continuous high-pressure negative suction drain, successful management of seroma was obtained without any major complication such as wound infection, flap loss, and wound margin necrosis, except for only 1 case of seroma after discharge from the hospital. The indwelling time of the drain in the latissimus dorsi donor site was significantly reduced in comparison with the authors' previous data (P = 0.047). The volume of drainage and hospitalization period were also reduced; however, these were not statistically significant. The dead space with continuous high-pressure negative suction drain was more reduced than in the control group in the immediate postoperative period and confirmed with ultrasonography.
   Conclusions: Continuous high-pressure negative suction drain might be the simple and powerful solution in the management of challenging closed wounds.
C1 [Shin, Seung Jun; Han, DaeHee; Song, Hyunsuk; Jang, Yu Jin; Park, Dong Ha; Park, Myong Chul] Ajou Univ Hosp, Dept Plast & Reconstruct Surg, Suwon 443721, Gyeonggi Do, South Korea.
C3 Ajou University; Ajou University Hospital
RP Park, MC (通讯作者)，Ajou Univ Hosp, Dept Plast & Reconstruct Surg, Suwon 443721, Gyeonggi Do, South Korea.
EM mpark@ajou.ac.kr
CR Agrawal A, 2006, ANZ J SURG, V76, P1088, DOI 10.1111/j.1445-2197.2006.03949.x
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   Lee DL, 2011, INT WOUND J, V8, P406, DOI 10.1111/j.1742-481X.2011.00813.x
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NR 15
TC 6
Z9 10
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD JUL
PY 2014
VL 25
IS 4
BP 1427
EP 1431
DI 10.1097/SCS.0000000000000575
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AN0EZ
UT WOS:000340257800116
PM 24905942
DA 2026-07-24
ER
PT J
AU Linkov, G
   Cracchiolo, J
   Fielding, AF
   Liu, JC
AF Linkov, Gary
   Cracchiolo, Jennifer
   Fielding, Allen F.
   Liu, Jeffrey C.
TI Facial Nerve Function Preservation With Vacuum-Assisted Closure
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Vacuum-assisted closure; necrotizing fasciitis; facial nerve
   preservation; facial wound
ID NECK; WOUNDS; HEAD; MANAGEMENT
AB Importance: Laboratory and clinical studies have shown that vacuum-assisted closure (VAC) therapy increases wound blood flow and granulation tissue formation and decreases accumulation of fluid and bacteria. Many publications outline the use of VAC dressings in the treatment of sternal, sacral, upper and lower extremity, perineal, and abdominal wounds, but few describe its use in the head and neck region. No report to date has addressed the use of VAC therapy in helping to preserve facial nerve integrity.
   Observations: We present a case of a 64-year-old woman who underwent tissue debridement for necrotizing fasciitis of the left face, neck, and upper chest. She subsequently had exposed facial nerve that was covered with a VAC dressing and demonstrated complete granulation by postoperative day 7 with preservation of function.
   Conclusions and Relevance: This case highlights the effectiveness of VAC in eliminating infectious material and promoting granulation tissue formation. This is the first time that VAC therapy has been shown to maintain neural function when placed directly on functioning cranial nerves.
C1 [Linkov, Gary; Cracchiolo, Jennifer; Liu, Jeffrey C.] Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19140 USA.
   [Fielding, Allen F.] Temple Univ, Sch Med, Dept Oral & Maxillofacial Surg, Philadelphia, PA 19140 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Temple University
RP Linkov, G (通讯作者)，Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 3401 N Broad St, Philadelphia, PA 19140 USA.
EM Gary.Linkov@tuhs.temple.edu
OI Liu, Jeffrey/0000-0001-8377-0905; Linkov, Gary/0000-0001-8584-5851
CR Byrnside V, 2010, J ORAL MAXIL SURG, V68, P935, DOI 10.1016/j.joms.2009.09.113
   Dhir K, 2009, LARYNGOSCOPE, V119, P54, DOI 10.1002/lary.20000
   Gallo O, 2012, LARYNGOSCOPE, V122, P785, DOI 10.1002/lary.22403
   Reiter M, 2013, AM J OTOLARYNG, V34, P411, DOI 10.1016/j.amjoto.2013.03.001
   Yang YH, 2013, J PLAST RECONSTR AES, V66, pE209, DOI 10.1016/j.bjps.2013.03.006
NR 5
TC 7
Z9 8
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD JUL
PY 2014
VL 25
IS 4
BP 1560
EP 1561
DI 10.1097/SCS.0000000000000963
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AN0EZ
UT WOS:000340257800152
PM 24926725
DA 2026-07-24
ER
PT J
AU Liu, DH
   Zhang, LH
   Li, TT
   Wang, GQ
   Du, HL
   Hou, HP
   Han, L
   Tang, PF
AF Liu, Daohong
   Zhang, Lihai
   Li, Tongtong
   Wang, Guoqi
   Du, Hailong
   Hou, Hongping
   Han, Li
   Tang, Peifu
TI Negative-Pressure Wound Therapy Enhances Local Inflammatory Responses in
   Acute Infected Soft-Tissue Wound
SO CELL BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Infection; Negative-pressure wound therapy; Inflammatory; Cytokine
ID VACUUM-ASSISTED CLOSURE; IL-1 RECEPTOR ANTAGONIST;
   STAPHYLOCOCCUS-AUREUS; GENE-EXPRESSION; NEUTROPHIL RECRUITMENT; IN-VIVO;
   INTERLEUKIN-8; MECHANISMS; SYSTEM; INJURY
AB Clinical studies found that negative-pressure wound therapy (NPWT) displayed significant clinical benefits in the healing of infected wounds. However, the effect of NPWT on local inflammatory responses in acute infected soft-tissue wound has not been investigated thoroughly. The purpose of this study was to test the impact of NPWT on local expression of proinflammatory cytokines, amount of neutrophils, and bacterial bioburden in wound from acute infected soft-tissue wounds. Full-thickness wounds were created on the back of rabbits, and were inoculated with Staphylococcus aureus strain ATCC29213. The wounds were treated with sterile saline-moistened gauze dressings and NPWT with continuous negative pressure (-125 mmHg). Wound samples were harvested on days 0 (6 h after bacterial inoculation), 2, 4, 6, and 8 at the center of wound beds before irrigation for real-time PCR analysis of gene expression of IL-1 beta, IL-8, and TNF-alpha. Wound biopsies were examined histologically for neutrophil quantification in different layers of tissue. Quantitative bacterial cultures at the same time point were analyzed for bacterial clearance. Application of NPWT to acute infected wounds in rabbits was compared with treatment with sterile saline-moistened gauze, over an 8-day period. NPWT-treated wounds exhibited earlier and greater peaking of IL-1 beta and IL-8 expression and decrease in TNF-alpha expression over the early 4 days (P < 0.05). Furthermore, histologic examination revealed that significantly increased neutrophil count was observed in the shallow layer in wound biopsies of NPWT treatment at day 2 (P < 0.001). In addition, there was a statistically significant decrease of bacteria load from baseline (day 0) at days 2 and 8 in NPWT group (P < 0.05). In conclusion, this study demonstrates that NPWT of acute infected soft-tissue wounds leads to increased local IL-1 beta and IL-8 expression in early phase of inflammation, which may trigger accumulation of neutrophils and thus accelerate bacterial clearance. Meanwhile, the success of NPWT in the treatment of acute wounds can attenuate the expression of TNF-alpha, and the result may partly explain how NPWT can avoid significantly impairing wound healing.
C1 [Liu, Daohong; Zhang, Lihai; Li, Tongtong; Wang, Guoqi; Du, Hailong; Hou, Hongping; Tang, Peifu] Peoples Liberat Army, Dept Orthopaed, Genearl Hosp, Beijing 100853, Peoples R China.
   [Han, Li] Chinese PLA Inst Dis Control & Prevent, Ctr Hosp Infect Control, Beijing 100071, Peoples R China.
RP Tang, PF (通讯作者)，Peoples Liberat Army, Dept Orthopaed, Genearl Hosp, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM hanlicdc@163.com; drpeifutang@163.com
RI Hou, Hongping/ABQ-8065-2022
OI Tang, Peifu/0000-0003-4279-1704
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NR 44
TC 37
Z9 40
U1 1
U2 15
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1085-9195
EI 1559-0283
J9 CELL BIOCHEM BIOPHYS
JI Cell Biochem. Biophys.
PD SEP
PY 2014
VL 70
IS 1
BP 539
EP 547
DI 10.1007/s12013-014-9953-0
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA AN4XN
UT WOS:000340593200075
PM 24748178
DA 2026-07-24
ER
PT J
AU Hutan, M
   Bartko, C
   Majesky, I
   Prochotsky, A
   Sekac, J
   Skultety, J
AF Hutan, Martin
   Bartko, Christian
   Majesky, Ivan
   Prochotsky, Augustin
   Sekac, Jaroslav
   Skultety, Jan
TI Reconstruction option of abdominal wounds with large tissue defects
SO BMC SURGERY
LA English
DT Article
DE NPWT; Split skin grafting; Abdominal wall defect
ID INTRAPERITONEAL COMPOSITE MESH; VACUUM PACK TECHNIQUE; VASCULAR
   SURGICAL-PATIENTS; WALL DEFECTS; HERNIA REPAIR; INCISIONAL
   HERNIORRHAPHY; 7-YEAR EXPERIENCE; TEMPORARY CLOSURE; INGUINAL-HERNIA;
   INFECTION RISK
AB Background: Abdominal wall defects result from trauma, abdominal wall tumors, necrotizing infections or complications of previous abdominal surgeries. Apart from cosmetics, abdominal wall defects have strong negative functional impact on the patients.
   Many different techniques exist for abdominal wall repair. Most problematic and troublesome are defects, where major part of abdominal wall had to be resected and tissue for transfer or reconstruction is absent.
   Case presentation: Authors of the article present operative technique, in which reconstruction of abdominal wall was managed by composite polypropylene mesh with absorbable collagen film, creation of granulation tissue with use of NPWT (negative pressure wound therapy), and subsequent split skin grafting. Three patients with massive abdominal wall defect were successfully managed and abdominal wall reconstruction was performed by mentioned technique. Functional and cosmetic effect is acceptable and patients have good postoperative quality of life.
   Conclusions: Patients with giant abdominal defects can benefit from described technique. It serves as the only option, with which abdominal wall is fully reconstructed without need for the secondary intervention.
C1 [Hutan, Martin; Bartko, Christian; Majesky, Ivan; Prochotsky, Augustin; Sekac, Jaroslav; Skultety, Jan] Comenius Univ, Fac Med, Surg Clin 2, Univ Hosp Bratislava,Hosp st Cyril & Methodius, Bratislava 85107, Slovakia.
C3 Comenius University Bratislava; Slovak Medical University Bratislava
RP Hutan, M (通讯作者)，Comenius Univ, Fac Med, Surg Clin 2, Univ Hosp Bratislava,Hosp st Cyril & Methodius, Antolska 11, Bratislava 85107, Slovakia.
EM matohuto@yahoo.com
OI Bartko, Christian/0009-0002-5274-0230
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NR 30
TC 11
Z9 13
U1 0
U2 23
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD AUG 8
PY 2014
VL 14
AR 50
DI 10.1186/1471-2482-14-50
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AN5QQ
UT WOS:000340646800001
PM 25103782
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ousey, KJ
   Milne, J
   Cook, L
   Stephenson, J
   Gillibrand, W
AF Ousey, Karen J.
   Milne, Jeanette
   Cook, Leanne
   Stephenson, John
   Gillibrand, Warren
TI A pilot study exploring quality of life experienced by patients
   undergoing negative-pressure wound therapy as part of their wound care
   treatment compared to patients receiving standard wound care
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Quality of life; Social isolation
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; CHRONIC LEG
   ULCERATION; SATISFACTION
AB The use of negative pressure wound therapy (NPWT) has been widely documented as a technique to help heal complex wounds. This article presents the findings of a preliminary study which aimed to explore quality of life (QoL) experienced by patients undergoing NPWT as part of their wound care treatment in comparison to that of patients with a wound using traditional (standard) wound care therapies. A quasi-experimental study was undertaken, with patients treated in wound care/vascular clinics with chronic/acute wounds. QoL impact was measured using the Cardiff Wound Impact Schedule and administered post-consent at timed intervals. Our results identified that there were no real differences in QoL scores recorded by patients over the 12-week period. Although there was no overall interaction between the therapies used for wound healing, NPWT did have an effect on social life: during the first 2 weeks of the application of therapy, patients in the NPWT group reported an increase in the social life domain. The authors conclude that true QoL can only be elicited if an accurate baseline is established or if data is collected over a long enough period to allow comparison of scores over time.
C1 [Ousey, Karen J.; Cook, Leanne; Stephenson, John; Gillibrand, Warren] Univ Huddersfield, Ctr Hlth & Social Care Res, Sch Human & Hlth Sci, Huddersfield HD1 3DH, W Yorkshire, England.
   [Milne, Jeanette] South Tyneside Fdn Trust Community Serv, Hebburn NE31 1AT, Tyne & Wear, England.
C3 University of Huddersfield
RP Ousey, KJ (通讯作者)，Univ Huddersfield, Ctr Hlth & Social Care, Sch Human & Hlth Sci, Ramsden Bldg, Huddersfield HD1 3DH, W Yorkshire, England.
EM k.j.ousey@hud.ac.uk
RI ; Ousey, Karen/W-1881-2018
OI Stephenson, John/0000-0002-7902-1837; Ousey, Karen/0000-0002-6993-9425;
   Gillibrand, Warren/0000-0001-8122-2833
FU Smith and Nephew
FX Cardiff Wound Healing Centre for permission to use CWIS. We thank all
   the practitioners for their help with recruitment and data collection
   and to the patients who completed the questionnaires. This study was
   funded by a non-restrictive educational grant from Smith and Nephew.
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   Wounds UK, 2008, BEST PRACT STAT GAUZ
NR 27
TC 13
Z9 15
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2014
VL 11
IS 4
BP 357
EP 365
DI 10.1111/j.1742-481X.2012.01098.x
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Surgery
GA AN5XH
UT WOS:000340665000005
PM 23095095
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Mark, KS
   Alger, L
   Terplan, M
AF Mark, Katrina S.
   Alger, Lindsay
   Terplan, Mishka
TI Incisional Negative Pressure Therapy to Prevent Wound Complications
   Following Cesarean Section in Morbidly Obese Women: A Pilot Study
SO SURGICAL INNOVATION
LA English
DT Article
DE obesity; cesarean section; wound complication; negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; INFECTIONS; MANAGEMENT
AB Objective. We sought to evaluate the efficacy of incisional negative pressure therapy in decreasing postoperative wound complications when placed prophylactically over clean, closed incisions following cesarean section in obese patients. Study design. This was a retrospective cohort study comparing rates of wound complications following cesarean sections in morbidly obese women prior to and following the institution of standard use of prophylactic incisional negative pressure therapy. All women with a body mass index greater than 45 kg/m(2) undergoing cesarean section in a 2-year period in a single institution were included. The exposure was incisional negative pressure therapy, which began in September 2009, versus standard wound dressing used in the previous year. The main outcome was wound complication identified by ICD-9 codes. Demographic and wound outcomes were compared with chi(2) and t tests. Stata version 11.0 was used for all analysis. Results. A total of 63 women met the inclusion criteria, 21 of whom received negative pressure wound therapy. The historical comparison and exposure groups were similar in all characteristics studied with the exceptions of length of surgery (64 vs 76 minutes, P =.03), length of labor (78 vs 261 minutes, P =.02), scheduled versus nonscheduled (77% vs 52%, P =.04), and mean age (29.5 vs 26.1 years, P =.04), respectively. There were 5 wound complications in the control group (10.4%) and none (0%) in the study group (P =.15). Conclusions. This pilot study suggests a decrease in wound complications in morbidly obese women receiving incisional negative pressure therapy following cesarean section.
C1 [Mark, Katrina S.; Alger, Lindsay; Terplan, Mishka] Univ Maryland, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP Mark, KS (通讯作者)，Univ Maryland, Dept Obstet Gynecol & Reprod Sci, 11 S Paca St,Suite 400, Baltimore, MD 21201 USA.
EM kmark@fpi.umaryland.edu
OI Mark, Katrina/0000-0001-5127-2936
CR Alanis M C, 2010, AM J OBSTET GYNECOL, V203, p271e1, DOI DOI 10.1016/J.AJ0G.2010.06.049
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NR 25
TC 46
Z9 48
U1 0
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD AUG
PY 2014
VL 21
IS 4
BP 345
EP 349
DI 10.1177/1553350613503736
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AN6PD
UT WOS:000340716600001
PM 24056202
DA 2026-07-24
ER
PT J
AU Sunn, G
AF Sunn, Gabriel
TI Spinal Cord Injury Pressure Ulcer Treatment An Experience-Based Approach
SO PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
LA English
DT Article
DE Pressure ulcer; Pressure ulcer treatment; Spinal cord injury; Wound
   dressing; Wound healing
ID MANAGEMENT; OUTCOMES
AB Pressure ulcers continue to impact the lives of spinal cord injury patients severely. Pressure ulcers must be accurately staged according to National Pressure Ulcer Advisory recommendations before treatment design. The first priority in treatment of pressure ulcers is offloading. Intact skin ulcers may be treated with noncontact nonthermal low-frequency ultrasound. Superficial pressure ulcers may be treated with a combination of collagenase and foam dressings. Deeper pressure ulcers warrant negative-pressure wound therapy dressings along with biologic adjuncts to fill in wound depth. Discovery and treatment of osteomyelitis is a high priority when initially evaluating pressure ulcers. Surgical intervention must always be considered.
C1 [Sunn, Gabriel] Miami VA Hosp, Spinal Cord Injury Unit, Miami, FL 33125 USA.
   [Sunn, Gabriel] Univ Miami, Miller Sch Med, Dept Phys Med & Rehabil, Miami, FL 33101 USA.
C3 University of Miami
RP Sunn, G (通讯作者)，Miami VA Hosp, Spinal Cord Injury Unit, 1C,1201 Northwest 16th St, Miami, FL 33125 USA.
EM gabriel.sunn@gmail.com
CR Chan BC, 2013, INT WOUND J, V10, P431, DOI 10.1111/j.1742-481X.2012.01002.x
   Dorsett P, 2008, SPINAL CORD, V46, P386, DOI 10.1038/sj.sc.3102159
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Fowler E, 2008, OSTOMY WOUND MANAG, V54, P42
   Gélis A, 2009, SPINAL CORD, V47, P651, DOI 10.1038/sc.2009.32
   James GA, 2008, WOUND REPAIR REGEN, V16, P37, DOI 10.1111/j.1524-475X.2007.00321.x
   Kitagawa Tsunemi, 2002, Journal of Nippon Medical School, V69, P268, DOI 10.1272/jnms.69.268
   Pineda Carlos, 2009, Semin Plast Surg, V23, P80, DOI 10.1055/s-0029-1214160
   Scheel-Sailer A, 2013, SPINAL CORD, V51, P828, DOI 10.1038/sc.2013.91
   Shi L, 2009, J WOUND OSTOMY CONT, V36, pS12, DOI 10.1097/WON.0b013e3181bfdd1a
   Srivastava A, 2009, J SPINAL CORD MED, V32, P125, DOI 10.1080/10790268.2009.11760763
NR 11
TC 7
Z9 11
U1 1
U2 33
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1047-9651
EI 1558-1381
J9 PHYS MED REH CLIN N
JI Phys. Med. Rehabil. Clin. N. Am.
PD AUG
PY 2014
VL 25
IS 3
BP 671
EP +
DI 10.1016/j.pmr.2014.05.002
PG 11
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA AN6UU
UT WOS:000340734700012
PM 25064794
DA 2026-07-24
ER
PT J
AU Tansarli, GS
   Vardakas, KZ
   Stratoulias, C
   Peppas, G
   Kapaskelis, A
   Falagas, ME
AF Tansarli, Giannoula S.
   Vardakas, Konstantinos Z.
   Stratoulias, Constantinos
   Peppas, George
   Kapaskelis, Anastasios
   Falagas, Matthew E.
TI Vacuum-Assisted Closure versus Closure without Vacuum Assistance for
   Preventing Surgical Site Infections and Infections of Chronic Wounds: A
   Meta-Analysis of Randomized Controlled Trials
SO SURGICAL INFECTIONS
LA English
DT Review
ID DIABETIC FOOT ULCERS; THERAPY; MULTICENTER; FRACTURES
AB Objectives: We sought to examine whether vacuum-assisted closure (VAC) is associated with fewer surgical site infections (SSIs) or infections of chronic wounds than other management procedures for surgical wounds.
   Methods: The PubMed and Scopus databases were searched systematically. Randomized controlled trials (RCTs) comparing the development of SSIs or infections of chronic wounds between patients treated with VAC for acute or chronic wounds and those whose wounds were treated without VAC were considered eligible for inclusion in the study.
   Results: Eight RCTs met the inclusion criteria for the study. Four of the studies included chronic or diabetic lower extremity wounds and four included fractures. In three of four studies reporting on fractures, the wounds were not closed post-operatively, whereas in one study primary closure of the wound was performed. With regard to wounds left open after the stabilization of fractures, patients whose wounds were treated with VAC developed fewer SSIs than those whose wounds were treated without VAC ([367 patients (196 with VAC; 171 without VAC) relative risk [RR], 0.47; 95% CI 0.28-0.81]). On the contrary, no difference in the development of SSIs occurred among patients with chronic or diabetic lower-extremity wounds treated with VAC and those whose wounds were treated without VAC ([638 patients (320 with VAC; 318 without VAC) RR 1.67; 95% CI: 0.71-3.94]).
   Conclusion: The available evidence suggests that the development of infections in wounds treated with VAC depends on the type of wound being treated.
C1 [Tansarli, Giannoula S.; Vardakas, Konstantinos Z.; Peppas, George; Kapaskelis, Anastasios; Falagas, Matthew E.] Alfa Inst Biomed Sci, Athens 15123, Greece.
   [Vardakas, Konstantinos Z.; Kapaskelis, Anastasios; Falagas, Matthew E.] IASO Gen Hosp, IASO Grp, Dept Internal Med Infect Dis, Athens, Greece.
   [Stratoulias, Constantinos] Mitera Hosp, Hygeia Grp, Dept Surg, Athens, Greece.
   [Falagas, Matthew E.] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA.
C3 Alfa Institute Of Biomedical Sciences; Tufts University
RP Falagas, ME (通讯作者)，Alfa Inst Biomed Sci, 19 Neapoleos St, Athens 15123, Greece.
EM m.falagas@aibs.gr
RI /M-5253-2019
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
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   Brem H, 2007, J CLIN INVEST, V117, P1219, DOI 10.1172/JCI32169
   Diener H, 2009, CHIRURG, V80, P814, DOI 10.1007/s00104-009-1692-1
   Gregor S, 2008, ARCH SURG-CHICAGO, V143, P189, DOI 10.1001/archsurg.2007.54
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   Moher D, 1998, LANCET, V352, P609, DOI 10.1016/S0140-6736(98)01085-X
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   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
   Suissa D, 2011, PLAST RECONSTR SURG, V128, p498E, DOI 10.1097/PRS.0b013e31822b675c
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 20
TC 3
Z9 5
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD AUG
PY 2014
VL 15
IS 4
BP 363
EP 367
DI 10.1089/sur.2013.028
PG 5
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA AO0PY
UT WOS:000341014100001
PM 24810943
DA 2026-07-24
ER
PT J
AU Succar, J
   Douaiher, J
   Lancerotto, L
   Li, Q
   Yamaguchi, R
   Younan, G
   Pejler, G
   Orgill, DP
AF Succar, Julien
   Douaiher, Jeffrey
   Lancerotto, Luca
   Li, Qiong
   Yamaguchi, Ryushiro
   Younan, George
   Pejler, Gunnar
   Orgill, Dennis P.
TI The Role of Mouse Mast Cell Proteases in the Proliferative Phase of
   Wound Healing in Microdeformational Wound Therapy
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; IMMUNE CELLS; CHYMASE; FIBRONECTIN; TRYPTASE;
   ACTIVATION; TISSUE; ANGIOGENESIS; MATRIX; LINK
AB Background: Stored in the secretory granules of cutaneous mouse mast cells are mouse mast cell proteases (mMCP-4, -5, and -6). Using transgenic mouse lines that lacked these enzymes, it was shown that mMCP-4 and mMCP-5 modulate the outcome of burn-induced skin injury. Whether or not these proteases also play a role in the repair of surgically damaged skin, with or without microdeformational wound therapy, remains to be determined.
   Methods: Wild-type C57BL/6 mice and transgenic C57BL/6 mouse lines lacking mMCP-4, -5, or -6 were subjected to surgical wounding of their skin. Wounds were splinted with a stabilizing patch, and the mice received either microdeformational wound therapy (n = 5) or occlusive dressing (n = 5) for 7 days. Wound healing parameters were assessed in the proliferative phase.
   Results: Cell proliferation in the wounded wild-type mice receiving microdeformational wound therapy was 60 +/- 3 percent. Cell proliferation was only 35 +/- 5 percent, 25 +/- 5 percent, and 45 +/- 4 percent for the treated mMCP-4, mMCP-5, and mMCP-6 null mice, respectively (p = 0.005). Blood vessel sprouting was higher in the control mice with microdeformational wound therapy (170 +/- 40 vessels/high-power field) compared with mouse mast cell protease 6 null mice with microdeformational wound therapy (70 +/- 20 vessels/high-power field; p = 0.005), and higher in the control mice with occlusive dressing (110 +/- 30 vessels/high-power field) compared with mMCP-4 null mice with occlusive dressing (50 +/- 20 vessels/high-power field; p = 0.01). Qualitatively, the granulation tissue of all the protease-deficient groups receiving microdefoimational wound therapy was disrupted.
   Conclusion: Results suggest that mouse mast cell proteases 4, 5, and 6 are mediators of the critical role mast cells play in microdefoi national wound therapy in the proliferative phase of healing.
C1 Univ Kentucky, Dept Gen Surg, Lexington, KY 40506 USA.
   Johns Hopkins Univ, Dept Gen Surg, Baltimore, MD 21218 USA.
   Univ Padua, Dept Plast Surg, I-35100 Padua, Italy.
   Changzheng Hosp, Dept Plast Surg, Shanghai, Peoples R China.
   Mito Chuo Hosp, Dept Surg, Mito, Ibaraki, Japan.
   Inova Fairfax Hosp, Dept Gen Surg, Falls Church, VA USA.
   Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, S-90183 Umea, Sweden.
   Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
C3 University of Kentucky; Johns Hopkins University; University of Padua;
   Naval Medical University; Inova Fairfax Hospital; Swedish University of
   Agricultural Sciences; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University
RP Orgill, DP (通讯作者)，75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI ; Orgill, Dennis/H-7596-2019; Lancerotto, Luca/A-5745-2013
OI Younan, George/0000-0001-8502-4850; 
CR Abonia JP, 2005, J IMMUNOL, V174, P7285, DOI 10.4049/jimmunol.174.11.7285
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NR 54
TC 14
Z9 18
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2014
VL 134
IS 3
BP 459
EP 467
DI 10.1097/PRS.0000000000000432
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AO1JU
UT WOS:000341069200008
PM 24814421
DA 2026-07-24
ER
PT J
AU Hendricks, N
   Hendricks, J
   Hoffmann, K
   Hemprich, A
   Halama, D
AF Hendricks, Nora
   Hendricks, Joerg
   Hoffmann, Karen
   Hemprich, Alexander
   Halama, Dirk
TI Using Medical Silicone to Ensure an Airtight Negative Pressure Wound
   Therapy Dressing Seal in Challenging Wounds: A Case Series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case series; negative pressure wound therapy; medical silicone;
   dressings; healing
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; TISSUE DEFECTS;
   RECONSTRUCTION; FOUNDATION; MANAGEMENT; PERFUSION; INTEGRA; TRIAL
AB Negative pressure wound therapy (NPWT) has been used for a broad range of indications and wound types. However, it can be difficult to maintain an airtight dressing seal when the wound is located in an anatomically challenging area or environment. To address this problem, medical silicone, used to create intraoral vacuum dressings, was used in five, patients (one woman, four men,, age range 57 to 66 years) to seal leaking NPWT dressings (four polyurethane dressings and one polyurethane silver foam dressing). The wounds were located in the head and neck, abdominal, lower extremity, and anogenital areas. Initial wound sizes ranged from 2.5 cm(2) to 700 cm(2), and periwound areas were characterized by irregular surfaces (scars, skin folds, or curved surfaces), humid milieu, or mobile structures. In all five patients, negative, pressure was set at -125 mm Hg constant suction, and the silicone was able to seal the leaking dressings. Wound size reductions from 2.5 cm(2) to 13.5 cm(2) were observed during 9 to 64 days (range) of NPWT treatment. In these patients,, medical silicone was found to be a suitable material to facilitate airtight sealing of the dressings used with NPWT.
C1 [Hendricks, Nora] Univ Hosp Leipzig, Dept Paediat & Prevent Dent, D-04103 Leipzig, Sachsen, Germany.
   [Hendricks, Joerg; Hemprich, Alexander; Halama, Dirk] Univ Hosp Leipzig, Dept Oral & Maxillofacial Surg, D-04103 Leipzig, Sachsen, Germany.
   [Hoffmann, Karen] Univ Hosp Leipzig, Dept Surg Med Wound Ostomy & Kinesiatr Management, D-04103 Leipzig, Sachsen, Germany.
C3 Leipzig University; Leipzig University; Leipzig University
RP Halama, D (通讯作者)，Univ Hosp Leipzig, Dept Oral & Maxillofacial Surg, Liebigstr 10-14, D-04103 Leipzig, Sachsen, Germany.
EM dirk.halama@medizin.uni-leipzig.de
RI Hemprich, Alexander/JXL-9631-2024
CR Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
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NR 29
TC 9
Z9 11
U1 0
U2 15
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD AUG
PY 2014
VL 60
IS 8
BP 40
EP 46
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AO2QZ
UT WOS:000341171600007
PM 25105477
DA 2026-07-24
ER
PT J
AU Seidel, D
   Mathes, T
   Lefering, R
   Storck, M
   Lawall, H
   Neugebauer, EAM
AF Seidel, Doerthe
   Mathes, Tim
   Lefering, Rolf
   Storck, Martin
   Lawall, Holger
   Neugebauer, Edmund A. M.
TI Negative pressure wound therapy versus standard wound care in chronic
   diabetic foot wounds: study protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Diabetic foot wound; Amputation wound; Chronic wound; Foot ulcer;
   Diabetic foot; Foot diseases; Diabetes complications; Diabetes mellitus;
   Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE
AB Background: In August 2010, the Federal Joint Committee (G-BA) decided that negative pressure wound therapy (NPWT) would not be reimbursable in German ambulatory care. This decision was based on reports from the Institute for Quality and Efficiency in Health Care (IQWiG), which concluded that there is no convincing evidence in favor of NPWT. The aim of this diabetic foot study (DiaFu study) is to evaluate whether the clinical, safety and economic results of NPWT are superior to the results of standard wound treatment.
   Methods/Design: The DiaFu study is designed as a national, multicenter, randomized controlled clinical superiority trial with a special focus on outpatient care in Germany. Competent patients in inpatient and outpatient care suffering from a chronic diabetic foot wound for a minimum of four weeks may be included in the study. The trial evaluates the treatment outcome of the application of a technical medical device which is based on the principle of NPWT (intervention group) in comparison to standard moist wound therapy (control group). All treatment systems used in the intervention group bear the symbol of free trade capacity in the European Union (CE mark) and will be operated within normal conditions of clinical routine and according to manufacturer's instructions. Primary endpoints are the time to complete wound healing and the rate of wound healing achieved in each group within the maximum study treatment time of 16 weeks. Primary endpoints will be confirmed by blinded assessment of wound photographs.
   Discussion: The DiaFu study will provide solid evidence regarding the efficacy and effectiveness of NPWT until 31 December 2014, the date when G-BA plans to decide on future reimbursement of NPWT in both ambulatory and in-hospital care. The study is designed to comply with all quality requirements of G-BA and IQWiG and will contribute to evidence-based wound care in Germany. The study has been initiated by the statutory health insurance companies in Germany and is co-funded by two manufacturers of NPWT systems.
C1 [Seidel, Doerthe; Mathes, Tim; Lefering, Rolf; Neugebauer, Edmund A. M.] Univ Witten Herdecke, Sch Med, Fac Hlth, Inst Res Operat Med IFOM, D-51109 Cologne, Germany.
   [Storck, Martin] Stadt Klinikum Karlsruhe gGmbH, D-76133 Karlsruhe, Germany.
   [Lawall, Holger] Asklepios Westklinikum Hamburg, Abt Angiol Diabetol, D-22559 Hamburg, Germany.
C3 Witten Herdecke University; Municipal Hospital Karlsruhe
RP Seidel, D (通讯作者)，Univ Witten Herdecke, Sch Med, Fac Hlth, Inst Res Operat Med IFOM, Ostmerheimer Str 200,Bldg 38, D-51109 Cologne, Germany.
EM Doerthe.Seidel@uni-wh.de
RI /L-6893-2017
FU Kinetic Concepts Incorporated (KCI); Smith Nephew (SN)
FX The authors declare that they have no personal competing interests. The
   overall study project was initiated and is funded by the involved
   statutory health insurance companies in Germany. This includes the
   provision of integrated care contracts for ambulant NPWT of study
   patients and for an additional cohort. The study is co-funded by the
   manufacturers of the evaluated medical products Kinetic Concepts
   Incorporated (KCI) and Smith & Nephew (S&N). This includes the personnel
   expenses for the study team. The Institute for Research in Operative
   Medicine is planning and conducting this clinical trial as an
   independent scientific institute.
CR [Anonymous], N0403 IQWIG
   [Anonymous], N0602 IQWIG
   [Anonymous], GUID IND CHRON CUT U
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NR 17
TC 15
Z9 16
U1 0
U2 44
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD AUG 27
PY 2014
VL 15
AR 334
DI 10.1186/1745-6215-15-334
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AO3FQ
UT WOS:000341215000001
PM 25158846
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Deng, ZM
   Cai, L
   Jin, W
   Ping, AS
   Wei, RX
AF Deng, Zhouming
   Cai, Lin
   Jin, Wei
   Ping, Ansong
   Wei, Renxiong
TI One-stage reconstruction with open bone grafting and vacuum-assisted
   closure for infected tibial non-union
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE vacuum-assisted closure; Papineau technique; tibial non-union; infected
ID SOFT-TISSUE TRANSFER; NON-UNION; SEGMENTAL DEFECTS; CHRONIC
   OSTEOMYELITIS; PAPINEAU TECHNIQUE; THERAPY; MANAGEMENT; ILIZAROV;
   WOUNDS; FRACTURES
AB Introduction: Non-union of the tibia complicated by osteomyelitis is one of the most challenging problems in orthopaedic surgery. There remains a significant amount of debate and controversy regarding the optimal medical management of infected tibial non-union. There are few articles which have reported the outcomes of treatment for infected non-union of tibia from single-stage reconstruction with open bone grafting plus vacuum-assisted closure (VAC).
   Material and methods: Our report covers experience between March 2007 and February 2010 of open bone grafting plus VAC in one stage for patients with infected tibial non-union. The time for bone union and wound healing to occur, the duration of hospitalisation, and the rate of resolution of infection were all analysed. The main outcome measures were based on a clinical scoring system that assessed functional ability, range of knee and ankle motion, shortening, infection and pain. Fifteen patients were involved in this study.
   Results: All patients were followed up for an average of 22.6 months (range: 14-42 months). Bone union was achieved in 93.3% (14/15) of patients after a mean of 5.93 months (range: 3-10 months). All wounds healed within an average period of 5 weeks (range: 3-10 weeks), and the function and appearance of all limbs were satisfactory.
   Conclusions: Open bone grafting combined with VAC in a one-stage procedure can be a feasible alternative to the treatment of infected tibial non-union, especially for those wounds which are not good candidates for microsurgery; however, further studies are required to confirm the likely benefits.
C1 [Deng, Zhouming; Cai, Lin; Jin, Wei; Ping, Ansong; Wei, Renxiong] Wuhan Univ, Zhongnan Hosp, Dept Orthopaed, Wuhan 430071, Hubei Province, Peoples R China.
C3 Wuhan University
RP Cai, L (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthopaed, 169 Donghu Rd, Wuhan 430071, Hubei Province, Peoples R China.
EM guke3559@yahoo.com.cn
RI Ping, An/GRJ-3145-2022; Li, Caiting/ABD-6818-2021
FU Fundamental Research Funds for the Central Universities [2012303020207]
FX This study was supported by the Fundamental Research Funds for the
   Central Universities (No. 2012303020207)
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NR 40
TC 20
Z9 24
U1 0
U2 10
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD AUG
PY 2014
VL 10
IS 4
BP 764
EP 772
DI 10.5114/aoms.2013.34411
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AO3YW
UT WOS:000341274400019
PM 25276163
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Baltzis, D
   Eleftheriadou, I
   Veves, A
AF Baltzis, Dimitrios
   Eleftheriadou, Ioanna
   Veves, Aristidis
TI Pathogenesis and Treatment of Impaired Wound Healing in Diabetes
   Mellitus: New Insights
SO ADVANCES IN THERAPY
LA English
DT Review
DE Diabetes mellitus; Foot ulceration; Ulcer treatment strategies; Wound
   healing
ID ENDOTHELIAL PROGENITOR CELLS; HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED
   CLOSURE; GROWTH-FACTOR; FOOT ULCERS; MATRIX-METALLOPROTEINASES;
   NEUROPATHIC ULCERS; MAST-CELLS; ANGIOGENESIS; MANAGEMENT
AB Diabetic foot ulcers (DFUs) are one of the most common and serious complications of diabetes mellitus, as wound healing is impaired in the diabetic foot. Wound healing is a dynamic and complex biological process that can be divided into four partly overlapping phases: hemostasis, inflammation, proliferative and remodeling. These phases involve a large number of cell types, extracellular components, growth factors and cytokines. Diabetes mellitus causes impaired wound healing by affecting one or more biological mechanisms of these processes. Most often, it is triggered by hyperglycemia, chronic inflammation, micro- and macro-circulatory dysfunction, hypoxia, autonomic and sensory neuropathy, and impaired neuropeptide signaling. Research focused on thoroughly understanding these mechanisms would allow for specifically targeted treatment of diabetic foot ulcers. The main principles for DFU treatment are wound debridement, pressure off-loading, revascularization and infection management. New treatment options such as bioengineered skin substitutes, extracellular matrix proteins, growth factors, and negative pressure wound therapy, have emerged as adjunctive therapies for ulcers. Future treatment strategies include stem cell-based therapies, delivery of gene encoding growth factors, application of angiotensin receptors analogs and neuropeptides like substance P, as well as inhibition of inflammatory cytokines. This review provides an outlook of the pathophysiology in diabetic wound healing and summarizes the established and adjunctive treatment strategies, as well as the future therapeutic options for the treatment of DFUs.
C1 [Baltzis, Dimitrios; Eleftheriadou, Ioanna] Joslin Beth Israel Deaconess Foot Ctr & Microcirc, Boston, MA USA.
   [Veves, Aristidis] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center
RP Veves, A (通讯作者)，Beth Israel Deaconess Med Ctr, One Deaconess Rd,PA-321A, Boston, MA 02215 USA.
EM aveves@bidmc.harvard.edu
OI Veves, Aristidis/0000-0002-3901-4405; Eleftheriadou,
   Ioanna/0000-0003-2763-2481
FU National Institute of Health [1R01DK091949, 1R01NS066205, 1R01DK076937,
   1R01NS046710, 1R24DK091210-01]
FX Sponsorship for this study was funded by the National Institute of
   Health Grants 1R01DK091949 (AV), 1R01NS066205 (AV, LPN) 1R01DK076937
   (AV), 1R01NS046710 (AV) and 1R24DK091210-01 (AV). All named authors meet
   the ICMJE criteria for authorship for this manuscript, take
   responsibility for the integrity of the work as a whole, and have given
   final approval for the version to be published.
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NR 91
TC 587
Z9 672
U1 7
U2 491
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0741-238X
EI 1865-8652
J9 ADV THER
JI Adv. Ther.
PD AUG
PY 2014
VL 31
IS 8
BP 817
EP 836
DI 10.1007/s12325-014-0140-x
PG 20
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA AO5ZO
UT WOS:000341426600004
PM 25069580
DA 2026-07-24
ER
PT J
AU Villa, R
   Costa, S
   Focchi, S
   Corbellini, C
   Vigorelli, M
   Avesani, EC
AF Villa, Roberta
   Costa, Stefano
   Focchi, Sibilla
   Corbellini, Carlo
   Vigorelli, Massimo
   Avesani, Ettore Contessini
TI Successful open abdomen treatment for multiple ischemic duodenal
   perforated ulcers in dermatomyositis
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Dermatomyositis; Duodenal perforations; Retroperitoneal air; Intestinal
   ischemia; Acute abdomen; Emergency surgery; Open abdomen
ID JUVENILE DERMATOMYOSITIS; MANIFESTATION; MANAGEMENT; THERAPY
AB Introduction: Dermatomyositis is an autoimmune disease characterized by proximal myopathy, cutaneous Gottron papules and heliotrope rash; intestinal involvement associated to acute vasculitis is less common but could be a life-threatening condition.
   Methods: A 21-year-old woman, affected by dermatomyositis, presented to our attention with a three-day story of severe abdominal pain, no bowel movement and biliary vomit. She was diagnosed with acute abdomen. A CT scan with bowel contrast demonstrated the presence of a leakage from the retroperitoneal aspect of duodenum. The surgical and clinical management in the light of literature review is presented.
   Results: Our first approach consisted in primary repair of the duodenal perforation with omentopexy. Post-operative course was complicated by hemorrhage. A reintervention showed a new perforation associated with multiple ischemic intestinal areas. We performed a gastroenteric anastomosis with functional exclusion of the damaged duodenum and positioning of drainages to create a biliary fistula. A nutritional enteric tube and an open abdomen vacuum-assisted closure system to monitor the fistula creation and to prevent abdominal contamination and collections were positioned. To reduce the amount of biliary leakage, a percutaneous transhepatic biliary drainage was placed, with progressive fistula flow disappearance in four months.
   Conclusions: In patients with dermatomyositis, when clinical findings and symptoms suggest abdominal vasculitis, it is very important to be aware of the risk of bowel and particularly duodenal perforations. Open abdomen treatment favors control of contamination by gastrointestinal contents, offers temporary abdominal closure, helps ICU care and delays definitive surgery.
C1 [Villa, Roberta; Costa, Stefano; Focchi, Sibilla; Corbellini, Carlo; Vigorelli, Massimo; Avesani, Ettore Contessini] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Gen & Emergency Surg, Milan, Italy.
   [Villa, Roberta; Focchi, Sibilla; Corbellini, Carlo; Avesani, Ettore Contessini] Univ Milan, Fac Med, Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan
RP Avesani, EC (通讯作者)，Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Gen & Emergency Surg, Milan, Italy.
EM ettore.contessini@unimi.it
OI Corbellini, Carlo/0000-0003-0814-0537
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NR 25
TC 5
Z9 5
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD AUG 30
PY 2014
VL 9
AR 48
DI 10.1186/1749-7922-9-48
PG 5
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA AO6HT
UT WOS:000341451800001
PM 26085838
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gudmundsdottir, I
   Steingrimsson, S
   Valsdottir, E
   Gudbjartsson, T
AF Gudmundsdottir, Ingibjorg
   Steingrimsson, Steinn
   Valsdottir, Elsa
   Gudbjartsson, Tomas
TI Negative pressure wound therapy - review
SO LAEKNABLADID
LA Icelandic
DT Article
DE Negative pressure wound therapy (NPWT); vacuum assisted closure; wound
   infection; treatment; outcome; review
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-CONTROLLED-TRIAL; SURGICAL SITE
   INFECTIONS; ABDOMINAL COMPARTMENT SYNDROME; POST-STERNOTOMY
   MEDIASTINITIS; MICROVASCULAR BLOOD-FLOW; OPEN-HEART-SURGERY;
   CARDIAC-SURGERY; POSTSTERNOTOMY MEDIASTINITIS; STERNOCUTANEOUS FISTULAS
AB Negative pressure wound therapy (NPWT) is a new therapeutic option in wound healing and was first described in its present form in 1997. A vacuum source is used to create sub-atmospheric pressure in the local wound environment to promote healing. This is achieved by connecting a vacuum pump to a tube that is threaded into a wound gauze or foam filler dressing covered with a drape. This concept in wound treatment has been shown to be useful in treating different wound infections, including diabetic wounds as well as complex infections of the abdomen and thorax. NPWT has been used in Iceland for over a decade and its use is steadily increasing. This review describes the indications and outcome of NPWT and is aimed at a broad group of doctors and nurses where recent Icelandic studies on the subject are covered.
C1 [Gudmundsdottir, Ingibjorg; Steingrimsson, Steinn; Valsdottir, Elsa; Gudbjartsson, Tomas] Landspitali Univ Hosp, Dept Surg, Reykjavik, Iceland.
   [Valsdottir, Elsa; Gudbjartsson, Tomas] Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.
C3 Landspitali National University Hospital; University of Iceland
RP Gudbjartsson, T (通讯作者)，Landspitali Univ Hosp, Dept Surg, Reykjavik, Iceland.
EM tomasgud@landspitali.is
RI Steingrimsson, Steinn/AAF-5475-2021
OI Steingrimsson, Steinn/0000-0001-8320-5607
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   Yu AW, 2013, INTERACT CARDIOV TH, V17, P861, DOI 10.1093/icvts/ivt326
NR 68
TC 1
Z9 1
U1 0
U2 19
PU LAEKNAFELAG ISLANDS-ICELANDIC MEDICAL ASSOC
PI KOPAVOGUR
PA HLIDASMARI 8, KOPAVOGUR, 200, ICELAND
SN 0023-7213
EI 1670-4959
J9 LAEKNABLADID
JI Laeknabladid
PD APR
PY 2014
VL 100
IS 4
BP 219
EP 224
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AO8QJ
UT WOS:000341619000002
PM 24713539
OA gold
DA 2026-07-24
ER
PT J
AU Chipp, E
   Sheena, Y
   Titley, OG
AF Chipp, E.
   Sheena, Y.
   Titley, O. G.
TI Extended applications of gauze-based negative pressure wound therapy in
   hand surgery: A review of five cases
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE wound; dressing; topical negative pressure; hand; upper limb
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS
AB Negative pressure wound therapy (NPWT) is an established treatment for a wide variety of acute and chronic wounds. Although the exact mechanism of action is still undefined, the proposed benefits of NPWT have been well described in the literature and include improved wound perfusion, granulation and reduction of oedema and bacteria. Here we describe a series of five challenging cases where NPWT dressings were applied for both elective and traumatic wounds of the upper limb. We describe the application of the dressing and the benefits seen in our patients. We believe the patients would have had inferior outcomes if managed by the best alternative conventional dressings.
C1 [Chipp, E.; Sheena, Y.; Titley, O. G.] Univ Hosp Birmingham, Birmingham Hand Ctr, Birmingham, W Midlands, England.
C3 University of Birmingham
RP Chipp, E (通讯作者)，Univ Hosp Birmingham, Birmingham Hand Ctr, Birmingham, W Midlands, England.
EM elizabeth_chipp@hotmail.com
OI Sheena, Yezen/0009-0000-2283-7811
CR Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
   Foo A, 2009, J PLAST RECONSTR AES, V62, pE129, DOI 10.1016/j.bjps.2008.05.030
   Hanasono MM, 2007, ANN PLAS SURG, V58, P573, DOI 10.1097/01.sap.0000237638.93453.66
   Kairinos N, 2010, J PLAST RECONSTR AES, V63, pE425, DOI 10.1016/j.bjps.2009.11.032
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
   Moiemen NS, 2010, BURNS, V36, P764, DOI 10.1016/j.burns.2010.04.011
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   Taylor CJ, 2011, J HAND SURG-AM, V36A, P1848, DOI 10.1016/j.jhsa.2011.08.023
NR 9
TC 2
Z9 2
U1 0
U2 4
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2014
VL 23
IS 9
BP 448
EP 451
DI 10.12968/jowc.2014.23.9.448
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AP0QY
UT WOS:000341769000007
PM 25284297
DA 2026-07-24
ER
PT J
AU Petit-Clair, N
   Smith, M
   Chernev, I
AF Petit-Clair, N.
   Smith, M.
   Chernev, I.
TI Modified NPWT using round channel drain for pacemaker pocket non-healing
   complex wound: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE round channel drain; negative pressure wound therapy; wound closure;
   pacemaker
ID ELECTRONIC DEVICE INFECTIONS; MANAGEMENT; THERAPY
AB Infection of cardiovascular implantable electronic devices poses a serious medical problem. Management of infected pocket wounds may be challenging for the physician and cause prolonged morbidity for the patient. The mainstay of treatment for infected cardiovascular implantable electronic devices is complete removal of the infected device and appropriate antibiotic therapy. In contrast, removal is not required for superficial or incisional infection at the pocket site if there is no involvement of the device. Here, we describe a modified negative pressure wound therapy (NPWT) technique using a round channel drain for pacemaker pocket non-healing complex wound, which started as a superficial incisional wound infection.
C1 [Petit-Clair, N.; Smith, M.] Avalon Univ, Sch Med, Youngstown, OH 44505 USA.
   [Smith, M.] Appalachian Reg Healthcare, Dept Surg, Beckley, WV USA.
   [Chernev, I.] Appalachian Reg Healthcare, Dept Med, Beckley, WV USA.
   [Chernev, I.] West Virginia Sch Osteopath Med, Lewisburg, WV USA.
RP Petit-Clair, N (通讯作者)，Avalon Univ, Sch Med, Youngstown, OH 44505 USA.
EM ivantchernev@yahoo.com
CR Baddour LM, 2010, CIRCULATION, V121, P458, DOI 10.1161/CIRCULATIONAHA.109.192665
   Mansoor J, 2013, INT WOUND J
   McGarry TJ, 2014, EUROPACE, V16, P372, DOI 10.1093/europace/eut305
   Mond HG, 2011, PACE, V34, P1013, DOI 10.1111/j.1540-8159.2011.03150.x
   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Sohail MR, 2010, EXPERT REV ANTI-INFE, V8, P831, DOI 10.1586/ERI.10.54
   Voigt A, 2010, PACE, V33, P414, DOI 10.1111/j.1540-8159.2009.02569.x
NR 7
TC 2
Z9 3
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2014
VL 23
IS 9
BP 453
EP 455
DI 10.12968/jowc.2014.23.9.453
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AP0QY
UT WOS:000341769000008
PM 25284298
DA 2026-07-24
ER
PT J
AU Zhu, J
   Yu, AX
   Qi, BW
   Li, ZH
   Hu, X
AF Zhu, Jin
   Yu, Aixi
   Qi, Baiwen
   Li, Zonghuan
   Hu, Xiang
TI Effects of Negative Pressure Wound Therapy on Mesenchymal Stem Cells
   Proliferation and Osteogenic Differentiation in a Fibrin Matrix
SO PLOS ONE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; HYDROSTATIC-PRESSURE;
   MECHANICAL STRAIN; BONE REGENERATION; STRETCH PROMOTES; VIABILITY;
   PATHWAYS
AB Vacuum-assisted closure (VAC) negative pressure wound therapy (NPWT) has been proven to be an effective therapeutic method for the treatment of recalcitrant wounds. However, its role in bone healing remains to be unclear. Here, we investigated the effects of NPWT on rat periosteum-derived mesenchymal stem cells (P-MSCs) proliferation and osteoblastic differentiation in a 3D fibrin matrix. P-MSCs underwent primary culture for three passages before being used to construct cell clots. The fibrin clots were incubated with NPWT under continuous suction at -125 mmHg in a subatmospheric perfusion bioreactor. Clots exposed to atmospheric pressure served as the static control. Compared to the control group, cell proliferation significantly increased in NPWT group after incubation for 3 days. There was no statistical difference in apoptosis rate between two groups. The ALP activity and mineralization of P-MSCs all increased under continuous suction. The expressions of collagen type 1 and transcription factor Cbfa-1 were higher at the 1-, 3-, and 7-day timepoints and the expressions of osteocalcin and integrin beta 5 were higher at the 3-, and 7-day timepoints in the NPWT group. These results indicate that a short time treatment with NPWT, applied with continuous suction at 2125 mmHg, can enhance cellular proliferation of P-MSCs and induce the differentiation toward an osteogenic phenotype. The mechanotransduction molecule integrin beta 5 was found to be highly expressed after NPWT treatment, which indicates that NPWT may play a positive role in fracture healing through enhance bone formation and decrease bone resorption.
C1 [Zhu, Jin; Yu, Aixi; Qi, Baiwen; Li, Zonghuan; Hu, Xiang] Wuhan Univ, Zhongnan Hosp, Dept Microorthoped, Wuhan 430072, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Microorthoped, Wuhan 430072, Peoples R China.
EM yuaixi666@hotmail.com
FU National Natural Science Foundation of China [81171713]; Hubei
   Provience's Outstanding Medical Academic Leader Program
FX This study was supported by the National Natural Science Foundation of
   China (no. 81171713) and the Hubei Provience's Outstanding Medical
   Academic Leader Program. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 37
TC 19
Z9 22
U1 1
U2 34
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 12
PY 2014
VL 9
IS 9
AR e107339
DI 10.1371/journal.pone.0107339
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AP0SM
UT WOS:000341774300059
PM 25216182
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hoeller, M
   Schintler, MV
   Pfurtscheller, K
   Kamolz, LP
   Tripolt, N
   Trop, M
AF Hoeller, Michael
   Schintler, Michael Valentin
   Pfurtscheller, Klaus
   Kamolz, Lars-Peter
   Tripolt, Norbert
   Trop, Marija
TI A retrospective analysis of securing autologous split-thickness skin
   grafts with negative pressure wound therapy in paediatric burn patients
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy; Autologous split-thickness skin graft;
   Treatment of paediatric burns; Mobility
ID VACUUM-ASSISTED CLOSURE
AB Background and Aim: Deep dermal and full-thickness burn wounds are excised and grafted with split-thickness skin grafts. Especially in less compliant patients such as young children, conventional fixing methods can often be ineffective due to high mobility rates in this age group.
   The aim of this retrospective single-centre study was to give an overview of our experience in the fixation of autologous split-thickness skin grafts (ASTSGs) on burn wounds by negative pressure wound therapy (NPWT) in paediatric patients.
   Methods: A retrospective analysis describing 53 paediatric patients with burns or burn-related injuries who were treated as 60 individual cases were conducted. All patients received ASTSGs secured by NPWT.
   Results: Of the individual cases, 60 cases with a mean age of 8 6 years (the youngest was 3 months, the eldest was 24 years old) were treated in a single procedure with ASTSG and NPWT. Total burn surface area (TBSA) was, median (med) 4.5% (3.0-12.0%). The TBSA of deep dermal thickness to full-thickness (IIb-III degrees) burns was med 4.0% (2.0-6.0%). The TBSA treated with ASTSG and NPWT was med 3.5% (2.0-6.0%). Take rate was, med 96% (90-99%) with a total range of 70-100%. The only significant correlation that could be found was between the grafted TBSA and the take rate. The smaller the grafted TBSA the better the take rate resulted, as expected. In three cases, major complications were noted.
   Conclusion: To sum up our experience, the NPWT system has developed itself to be a constant, well-implemented and useful tool in securing ASTSGs to the wound bed. The main advantage of the technique is a much higher mobility of the patient compared to conventional fixation methods. The high compliance rate of an often challenging group of patients such as children recompenses possible higher costs compared to conventional fixation methods. (C) 2013 Elsevier Ltd and ISBI. All rights reserved.
C1 [Hoeller, Michael; Pfurtscheller, Klaus; Trop, Marija] Med Univ Graz, Dept Paediat & Adolescent Med, Childrens Burn Unit, A-8010 Graz, Austria.
   [Schintler, Michael Valentin; Kamolz, Lars-Peter] Med Univ Graz, Dept Surg, Div Plast & Reconstruct Surg, A-8010 Graz, Austria.
   [Tripolt, Norbert] Med Univ Graz, Dept Internal Med, Div Endocrinol & Metab, A-8010 Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; Medical
   University of Graz
RP Hoeller, M (通讯作者)，Med Univ Graz, Dept Paediat & Adolescent Med, Childrens Burn Unit, Auenbruggerpl 34-2, A-8010 Graz, Austria.
EM michael.hoeller@klinikum-graz.at
RI Tripolt, Norbert/AFP-4429-2022
OI Kamolz, Lars-Peter/0000-0002-5975-876X
CR [Anonymous], COCHRANE DATABASE SY
   Baharestani M, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00607.x
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 21
TC 18
Z9 28
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD SEP
PY 2014
VL 40
IS 6
BP 1116
EP 1120
DI 10.1016/j.burns.2013.12.007
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA AP2JL
UT WOS:000341898400007
PM 24438740
DA 2026-07-24
ER
PT J
AU Choi, HJ
AF Choi, Hwan Jun
TI Cervical Necrotizing Fasciitis Resulting in Acupuncture and Herbal
   Injection for Submental Lipoplasty
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Acupuncture; complication; necrotizing fasciitis; wound infection;
   trauma
ID INFECTION; MEDICINE; PATIENT
AB Acupuncture is used for some conditions as an alternative to medication or surgical intervention. Several complications had been reported, and they are generally due to physical injury by the needle or transmission of diseases. Necrotizing fasciitis is an uncommon infection, but potentially lethal, especially when associated with systemic disorders such as diabetes. The authors report a case of serious cervical necrotizing fasciitis that developed after acupuncture and herbal injection treatment of fat accumulation of the submental area in a 32-year-old healthy woman. She presented with discharging wound over the submental area. The initial diagnosis was based on clinical information, in which localized necrosis areas in the cervical and chin regions were observed. Wide antibiotic therapy was applied, followed by surgical drainage, debridement, and negative pressure wound therapy. Culture was positive for Serratia liquefaciens and Staphylococcus intermedius. She made a good recovery.
C1 [Choi, Hwan Jun] Soonchunhyang Univ, Dept Plast & Reconstruct Surg, Coll Med, Cheonan, South Korea.
C3 Soonchunhyang University
RP Choi, HJ (通讯作者)，Soonchunhyang Univ, Cheonan Hosp, Dept Plast & Reconstruct Surg, 23-20 Byeongmyeong Dong, Cheonan Si 330721, Chuncheongnam D, South Korea.
EM medi619@hanmail.net
FU Soonchunhyang University Research Fund
FX This work was supported by the Soonchunhyang University Research Fund.
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   Konstantinov IE, 2008, ANN THORAC SURG, V86, P1973, DOI 10.1016/j.athoracsur.2008.05.004
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NR 18
TC 7
Z9 9
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD SEP
PY 2014
VL 25
IS 5
BP E507
EP E509
DI 10.1097/SCS.0000000000001120
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AP2VK
UT WOS:000341933600040
PM 25148627
DA 2026-07-24
ER
PT J
AU Saydam, FA
   Basaran, K
   Ceran, F
   Mert, B
AF Saydam, Funda Akoz
   Basaran, Karaca
   Ceran, Fatih
   Mert, Bulent
TI Foot Ischemia After a Free Fibula Flap Harvest: Immediate Salvage With
   an Interpositional Sapheneous Vein Graft
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Foot ischemia; free fibula flap; salvage
ID MAGNETIC-RESONANCE ANGIOGRAPHY; DONOR-SITE MORBIDITY; MANDIBULAR
   RECONSTRUCTION; COMPARTMENT SYNDROME; LOWER LEG; TRANSPLANTATION;
   VESSELS; HEAD
AB The most dreaded major donor-site complication of free fibula flap is a foot ischemia, which is fortunately rare. Various authors have discussed the efficacy of the use of preoperative imaging methods including color Doppler, magnetic resonance angiography, and conventional angiography. A 25-year-old man presented with a 10-cm mandibular defect after a facial gunshot injury. Lower extremity color Doppler revealed triphasic peroneal, tibialis anterior, and posterior artery flows. A fibula osteocutaneous flap was harvested, and the mandible was reconstructed. However, the suture sites at the donor site began to demonstrate signs of necrosis, abscess formation, and widespread cellulitis beginning from postoperative day 9. Angiogram of the lower extremity on the 13th day demonstrated no flow in the right posterior tibial artery distal to the popliteal artery, whereas the anterior tibial artery had weak flow with collateral filling distally. An emergency bypass with a saphenous vein graft between the popliteal artery and the distal posterior tibial artery was performed. Repeated debridements, local wound care, and vacuum-assisted closure were applied. A skin graft was placed eventually. The extremity healed without severe functional disability. In conclusion, although the arterial anatomy is completely normal in preoperative evaluation, vascular complications may still ocur at the donor fibula free flap site. In addition, emergency cardiovascular bypass surgery, as we experienced, may be necessary for limb perfusion.
C1 [Saydam, Funda Akoz; Basaran, Karaca; Ceran, Fatih] Bagcilar Training & Res Hosp, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkey.
   [Mert, Bulent] Bagcilar Training & Res Hosp, Dept Cardiovasc Surg, Istanbul, Turkey.
C3 Istanbul Bagcilar Training & Research Hospital; Istanbul Bagcilar
   Training & Research Hospital
RP Basaran, K (通讯作者)，Bagcilar Training & Res Hosp, Dept Plast Surg, Oztopuz Cad Camli Konak, Ulus Besiktas Istanbul, Turkey.
EM basarankaraca@gmail.com
RI Ceran, Fatih/JPK-6708-2023; Mert, Bülent/HLW-5592-2023; Basaran,
   Karaca/AHD-9009-2022
OI Ceran, Fatih/0000-0003-3403-1457; 
CR Ahmad N, 2007, J RECONSTR MICROSURG, V23, P199, DOI 10.1055/s-2007-981500
   Hölzle F, 2011, BRIT J ORAL MAX SURG, V49, P270, DOI 10.1016/j.bjoms.2010.05.002
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   Kelly AM, 2007, AM J ROENTGENOL, V188, P268, DOI 10.2214/AJR.04.1950
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NR 14
TC 6
Z9 9
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD SEP
PY 2014
VL 25
IS 5
BP 1784
EP 1786
DI 10.1097/SCS.0000000000000906
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AP2VK
UT WOS:000341933600087
PM 25119400
DA 2026-07-24
ER
PT J
AU Waltzman, JT
   Bell, DE
AF Waltzman, Joshua T.
   Bell, Derek E.
TI Vacuum-Assisted Closure Device as a Split-Thickness Skin Graft Bolster
   in the Burn Population
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID ALCOHOL; INJURY; FIRES; RISK
AB The vacuum-assisted closure device (VAC) is associated with improved wound healing outcomes. Its use as a bolster device to secure a split-thickness skin graft has been previously demonstrated; however, there is little published evidence demonstrating its benefits specifically in the burn population. With use of the VAC becoming more commonplace, its effect on skin graft take and overall time to healing in burn patients deserves further investigation. Retrospective review of burn registry database at a high-volume level I trauma center and regional burn center during a 16-month period was performed. Patients who had a third-degree burn injury requiring a split-thickness skin graft and who received a VAC bolster were included. Data points included age, sex, burn mechanism, burn location, grafted area in square centimeters, need for repeat grafting, percent graft take, and time to complete reepithelialization. Sixty-seven patients were included in the study with a total of 88 skin graft sites secured with a VAC. Age ranged from <1 year to 84 years (average 41 years). The average grafted area was 367 +/- 545 cm(2). The three most common were the leg, thigh, and arm (28, 15, and 12%, respectively). Average percent graft take was 99.5 +/- 1.5%. Notably, no patients returned to the operating room for repeat grafting. The average time to complete reepithelialization was 16 +/- 7 days. The VAC is a highly reliable and reproducible method to bolster a split-thickness skin graft in the burn population. The observed rate of zero returns to the operating room for repeat grafting was especially encouraging. Its ability to conform to contours of the body and cover large surface areas makes it especially useful in securing a graft. This method of bolstering results in decreased repeat grafting and minimal graft loss, thus decreasing morbidity compared with conventional bolster dressings.
C1 [Waltzman, Joshua T.; Bell, Derek E.] Univ Rochester, Med Ctr, Div Plast Surg, Rochester, NY 14642 USA.
C3 University of Rochester
RP Bell, DE (通讯作者)，Univ Rochester, Med Ctr, Div Plast Surg, Strong Mem Hosp, 601 Elmwood Ave,Box 661, Rochester, NY 14642 USA.
CR ALLER RD, 1982, JAMA-J AM MED ASSOC, V248, P1451, DOI 10.1001/jama.1982.03330120021019
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NR 17
TC 31
Z9 35
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD SEP-OCT
PY 2014
VL 35
IS 5
BP E338
EP E345
DI 10.1097/BCR.0000000000000009
PG 8
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA AP5CZ
UT WOS:000342098600008
PM 24577227
DA 2026-07-24
ER
PT J
AU Sziklavari, Z
   Ried, M
   Hofmann, HS
AF Sziklavari, Zsolt
   Ried, Michael
   Hofmann, Hans-Stefan
TI Vacuum-assisted closure therapy in the management of lung abscess
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Lung infection; Lung abscess; Surgery techniques; Vacuum-assisted
   closure; Negative-pressure wound therapy
ID COMPLEX PLEURAL EMPYEMA
AB Background: Despite significant advances in the treatment of thoracic infections, complex lung abscess remains a problem in modern thoracic surgery. We describe the novel application of vacuum-assisted closure for the treatment of a lung abscess. The technical details and preliminary results are reported.
   Methods: After the initial failed conservative treatment of an abscess, minimally invasive surgical intervention was performed with vacuum-assisted closure. The vacuum sponges were inserted in the abscess cavity at the most proximal point to the pleural surface. The intercostal space of the chest wall above the entering place was secured by a soft tissue retractor. The level of suction was initially set to 100 mm Hg, with a maximum suction of 125 mm Hg. The sponge was changed once on the 3rd postoperative day.
   Results: The abscess cavity was rapidly cleaned and decreased in size. The mini-thoracotomy could be closed on the 9th postoperative day. Closure of the cavity was simple, without any short-or long-term treatment failure. This technique reduced the trauma associated with the procedure. The patient was discharged on the 11th postoperative day.
   Conclusions: Vacuum-assisted closure systems should be considered for widespread use as an alternative option for the treatment of complicated pulmonary abscess in elderly, debilitated, immunocompromised patients after failed conservative treatment.
C1 [Sziklavari, Zsolt; Hofmann, Hans-Stefan] Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, D-93049 Regensburg, Germany.
   [Ried, Michael] Univ Regensburg, Dept Thorac Surg, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Sziklavari, Z (通讯作者)，Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, Pruferningerstr 86, D-93049 Regensburg, Germany.
EM zsolt.sziklavari@barmherzige-regensburg.de
RI Sziklavari, Zsolt/AGI-2440-2022; Ried, Michael/AAC-4518-2022
OI Ried, Michael/0000-0002-2365-4803
CR Bartlett JG, 2012, ANAEROBE, V18, P235, DOI 10.1016/j.anaerobe.2011.12.004
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NR 10
TC 4
Z9 6
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD SEP 6
PY 2014
VL 9
AR 157
DI 10.1186/s13019-014-0157-x
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA AP9FA
UT WOS:000342383000001
PM 25193086
OA Green Published, gold
DA 2026-07-24
ER
PT J
AU Violette, DB
AF Violette, David B., Jr.
TI The Search for the Missing 50-Year-Old Gold
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE gold injection; arthritis; wound matrix; negative pressure wound
   therapy; split-thickness skin graft
ID RHEUMATOID-ARTHRITIS
AB Intramuscular and subcutaneous injections of foreign bodies have been used for a number of years for a variety of reasons, including medical and cosmetic purposes. The author describes a case of chronic wound complications secondary to intramuscular gold injections for the treatment of rheumatoid arthritis. The lesions were completely excised, the defect first treated with negative-pressure wound therapy, and, ultimately, split-thickness skin grafting with excellent functional result.
C1 Lewis Gale Med Ctr, Salem, VA 24153 USA.
RP Violette, DB (通讯作者)，Lewis Gale Med Ctr, Salem, VA 24153 USA.
CR Forestier J, 1935, J LAB CLIN MED, V20, P827
   Hurst S, 2002, J RHEUMATOL, V29, P1639
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NR 5
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD OCT
PY 2014
VL 27
IS 10
BP 444
EP 446
DI 10.1097/01.ASW.0000450830.27549.47
PG 3
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA AQ1WE
UT WOS:000342573700003
PM 25225991
DA 2026-07-24
ER
PT J
AU Wu, JF
   Zhang, XD
   Zhao, QM
   Mao, DS
   Lu, X
AF Wu, Jinfang
   Zhang, Xudong
   Zhao, Qiming
   Mao, Dongsheng
   Lu, Xin
TI Vacuum Sealing Drainage in the Treatment of Migrated Polyacrylamide
   Hydrogel after Breast Augmentation: A Case Report
SO BREAST CARE
LA English
DT Article
DE Vacuum sealing drainage; Polyacrylamide hydrogel; Breast augmentation;
   Complications
ID THERAPY
AB Background: Polyacrylamide hydrogel (PAAG) injection for breast augmentation can result in a variety of complications, including implant migration. The migrated PAAG can become colonized by pathogens, resulting in secondary infections which can be extremely difficult to treat. Case Report: We report the case of a 43-year-old female patient who underwent PAAG injection for breast augmentation. Implant migration was diagnosed 8 years after the initial injection. Conclusion: Here, we report the first use of vacuum sealing drainage as a convenient and effective alternative to manage the complications of extensive PAAG migration after breast augmentation.
C1 [Wu, Jinfang; Zhang, Xudong; Zhao, Qiming; Mao, Dongsheng; Lu, Xin] 117 PLA Hosp, Dept Plast & Reconstruct Surg, Hangzhou 310013, Zhejiang, Peoples R China.
RP Zhang, XD (通讯作者)，117 PLA Hosp, Dept Plast & Reconstruct Surg, 14 Lin Ying Rd, Hangzhou 310013, Zhejiang, Peoples R China.
EM zxdyqky@yahoo.com.cn
RI Zhao, Qiming/OHU-6722-2025
CR Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Do ER, 2012, ARCH PLAST SURG-APS, V39, P267
   Labler L, 2009, J TRAUMA, V66, P749, DOI 10.1097/TA.0b013e318171971a
   Mouës CM, 2011, AM J SURG, V201, P544, DOI 10.1016/j.amjsurg.2010.04.029
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   Yu L, 2012, AESTHET PLAST SURG, V36, P1120, DOI 10.1007/s00266-012-9928-8
NR 6
TC 4
Z9 4
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-3791
EI 1661-3805
J9 BREAST CARE
JI Breast Care
PY 2014
VL 9
IS 4
BP 273
EP 275
DI 10.1159/000365954
PG 3
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA AQ2XR
UT WOS:000342653800008
PM 25404887
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Babiak, I
AF Babiak, Ireneusz
TI Open tibial fractures grade IIIC treated successfully with external
   fixation, negative-pressure wound therapy and recombinant human bone
   morphogenetic protein 7
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE NPWT; open tibial fracture grade IIIC; rhBMP-7; VAC-therapy
ID VACUUM-ASSISTED CLOSURE; BMP-7; SHAFT
AB The aim of the therapy in open tibial fractures grade III was to cover the bone with soft tissue and achieve healed fracture without persistent infection. Open tibial fractures grade IIIC with massive soft tissue damage require combined orthopaedic, vascular and plastic-reconstructive procedures. Negative-pressure wound therapy (NPWT), used in two consecutive cases with open fracture grade IIIC of the tibia diaphysis, healed extensive soft tissue defect with exposure of the bone. NPWT eventually allowed for wound closure by split skin graft within 21-25 days. Ilizarov external fixator combined with application of recombinant human bone morphogenetic protein-7 at the site of delayed union enhanced definitive bone healing within 16-18 months.
C1 Med Univ Warsaw, Dept Orthopaed & Traumatol, PL-02005 Warsaw, Poland.
C3 Medical University of Warsaw
RP Babiak, I (通讯作者)，Med Univ Warsaw, Dept Orthopaed & Traumatol, Ul Lindleya 4, PL-02005 Warsaw, Poland.
EM ibabiak@wum.edu.pl
OI Babiak, Ireneusz/0000-0002-8431-8969
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NR 35
TC 9
Z9 11
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2014
VL 11
IS 5
BP 476
EP 482
DI 10.1111/j.1742-481X.2012.01112.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AQ3BY
UT WOS:000342664900004
PM 23163923
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Yao, M
   Fabbi, M
   Hayashi, H
   Park, N
   Attala, K
   Gu, GS
   French, MA
   Driver, VR
AF Yao, Min
   Fabbi, Matteo
   Hayashi, Hisae
   Park, Nanjin
   Attala, Khaled
   Gu, Gousheng
   French, Michael A.
   Driver, Vickie R.
TI A retrospective cohort study evaluating efficacy in high-risk patients
   with chronic lower extremity ulcers treated with negative pressure wound
   therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Wound healing; Comorbidities; Low
   extremity chronic ulcers; Early intervention
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; CHRONIC VENOUS
   INSUFFICIENCY; DIABETIC FOOT ULCERS; LIMB SALVAGE; IMPACT; COSTS; CARE;
   MULTICENTER; MANAGEMENT
AB The purpose of this study was to evaluate the efficacy of negative pressure wound therapy (NPWT) compared with standard of care on wound healing in high-risk patients with multiple significant comorbidities and chronic lower extremity ulcers (LEUs) across the continuum of care settings. A retrospective cohort study of real-world' high-risk patients was conducted using Boston University Medical Center electronic medical records, along with chart abstraction to capture detailed medical history, comorbidities, healing outcomes and ulcer characteristics. A total of 342 patients, 171 NPWT patients with LEUs were matched with 171 non-NPWT patients with respect to age and gender, were included in this cohort from 2002 to 2010. The hazard ratios (HRs) were estimated by COX proportional hazard models after adjusting for potential confounders. The NPWT patients were 263 times (95% CI = 187-370) more likely to achieve wound closure compared with non-NPWT patients. Moreover, incidence of wound closure in NPWT patients were increased in diabetic ulcers (HR = 326, 95% CI = 221-483), arterial ulcers (HR = 227, CI = 156-378) and venous ulcers (HR = 631, 95% CI = 149-266) compared with non-NPWT patients. In addition, wound healing appeared to be positively affected by the timing of NPWT application. Compared with later NPWT users (1 year or later after ulcer onset), early NPWT users (within 3 months after ulcer onset) and intermediate NPWT users (4-12 months after ulcer onset) were 338 and 218 times more likely to achieve wound healing, respectively. This study showed that despite the greater significant comorbidities, patients receiving NPWT healed faster. Early use of NPWT demonstrated better healing. The longer the interval before intervention is with NPWT, the higher the correlation is with poor outcome.
C1 [Yao, Min; Fabbi, Matteo; Hayashi, Hisae; Park, Nanjin; Attala, Khaled; Gu, Gousheng; French, Michael A.; Driver, Vickie R.] VA New England Hlth Care Div, Providence, RI 02908 USA.
   [Yao, Min; Fabbi, Matteo; Hayashi, Hisae; Park, Nanjin; Attala, Khaled; Gu, Gousheng; French, Michael A.] Limb Preservat & Wound Care Res, Ctr Restorat & Regenerat Med, Dept Surg, Providence, RI USA.
   [Yao, Min; Driver, Vickie R.] Boston Med Ctr, Dept Surg, Boston, MA USA.
   [Yao, Min; Driver, Vickie R.] Boston Univ, Sch Med, Boston, MA 02118 USA.
   [Driver, Vickie R.] Ctr Restorat & Regenerat Med, Dept Surg, Providence, RI 02908 USA.
C3 Boston Medical Center; Boston University
RP Driver, VR (通讯作者)，VA New England Hlth Care Div, Providence, RI 02908 USA.
EM drvdriver@aol.com
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
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NR 32
TC 24
Z9 30
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2014
VL 11
IS 5
BP 483
EP 488
DI 10.1111/j.1742-481X.2012.01113.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AQ3BY
UT WOS:000342664900005
PM 23163962
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Dohmen, PM
   Markou, T
   Ingemansson, R
   Rotering, H
   Hartman, JM
   van Valen, R
   Brunott, M
   Segers, P
AF Dohmen, Pascal M.
   Markou, Thanasie
   Ingemansson, Richard
   Rotering, Heinrich
   Hartman, Jean M.
   van Valen, Richard
   Brunott, Maaike
   Segers, Patrique
TI Use of Incisional Negative Pressure Wound Therapy on Closed Median
   Sternal Incisions after Cardiothoracic Surgery: Clinical Evidence and
   Consensus Recommendations
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Cardiovascular Infections; Mediastinitis; Negative-Pressure Wound
   Therapy
ID VACUUM-ASSISTED CLOSURE; SURGICAL-SITE INFECTIONS; BYPASS GRAFT-SURGERY;
   RISK-FACTORS; CARDIAC-SURGERY; POSTOPERATIVE MEDIASTINITIS; DEEP;
   MANAGEMENT; COMPLICATIONS; PREVENTION
AB Negative pressure wound therapy is a concept introduced initially to assist in the treatment of chronic open wounds. Recently, there has been growing interest in using the technique on closed incisions after surgery to prevent potentially severe surgical site infections and other wound complications in high-risk patients. Negative pressure wound therapy uses a negative pressure unit and specific dressings that help to hold the incision edges together, redistribute lateral tension, reduce edema, stimulate perfusion, and protect the surgical site from external infectious sources. Randomized, controlled studies of negative pressure wound therapy for closed incisions in orthopedic settings (which also is a clean surgical procedure in absence of an open fracture) have shown the technology can reduce the risk of wound infection, wound dehiscence, and seroma, and there is accumulating evidence that it also improves wound outcomes after cardiothoracic surgery. Identifying at-risk individuals for whom prophylactic use of negative pressure wound therapy would be most cost-effective remains a challenge; however, several risk-stratification systems have been proposed and should be evaluated more fully. The recent availability of a single-use, closed incision management system offers surgeons a convenient and practical means of delivering negative pressure wound therapy to their high-risk patients, with excellent wound outcomes reported to date. Although larger, randomized, controlled studies will help to clarify the precise role and benefits of such a system in cardiothoracic surgery, limited initial evidence from clinical studies and from the authors' own experiences appears promising. In light of the growing interest in this technology among cardiothoracic surgeons, a consensus meeting, which was attended by a group of international experts, was held to review existing evidence for negative pressure wound therapy in the prevention of wound complications after surgery and to provide recommendations on the optimal use of negative pressure wound therapy on closed median sternal incisions after cardiothoracic surgery.
C1 [Dohmen, Pascal M.] Univ Leipzig, Heart Ctr Leipzig, Dept Cardiac Surg, D-04109 Leipzig, Germany.
   [Dohmen, Pascal M.] Univ Free State, Fac Hlth Sci, Dept Cardiothorac Surg, Bloemfontein, South Africa.
   [Markou, Thanasie] Isala Klinieken Zwolle, Dept Cardiothorac Surg, Zwolle, Netherlands.
   [Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Rotering, Heinrich] Univ Clin Munster, Dept Cardiothorac Surg, Munster, Germany.
   [Hartman, Jean M.] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiothorac Surg, NL-9713 AV Groningen, Netherlands.
   [van Valen, Richard; Brunott, Maaike] Erasmus Univ, Dept Cardiothorac Surg, Rotterdam, Netherlands.
   [Segers, Patrique] Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, NL-1105 AZ Amsterdam, Netherlands.
C3 Heart Center Leipzig GMBH; Leipzig University; University of the Free
   State; Lund University; Skane University Hospital; University of
   Munster; University of Groningen; Erasmus University Rotterdam; Erasmus
   University Rotterdam - Excl Erasmus MC; University of Amsterdam;
   Academic Medical Center Amsterdam
RP Dohmen, PM (通讯作者)，Univ Leipzig, Heart Ctr Leipzig, Dept Cardiac Surg, D-04109 Leipzig, Germany.
EM pascal.dohmen@yahoo.de
RI Segers, Patrick/IWM-4183-2023
OI Ingemansson, Richard/0000-0001-7623-8953
FU KCI Europe Holding B.V
FX Supporting grant provided by KCI Europe Holding B.V. All authors had
   final responsibility for the decision to submit the article for
   publication.
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NR 59
TC 31
Z9 36
U1 0
U2 17
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD OCT 4
PY 2014
VL 20
BP 1814
EP 1825
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AQ3EW
UT WOS:000342673400001
PM 25280449
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Saab, IR
   Sarhane, KA
   Ezzeddine, HM
   Abu-Sittah, GS
   Ibrahim, AE
AF Saab, I. R.
   Sarhane, K. A.
   Ezzeddine, H. M.
   Abu-Sittah, G. S.
   Ibrahim, A. E.
TI Treatment of a paediatric patient with a distal lower extremity
   traumatic wound using a dermal regeneration template and NPWT
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE degloving injury; dermal regeneration template; integra; lower extremity
   reconstruction; negative pressure wound therapy; vacuum-assisted closure
ID RECONSTRUCTIVE SURGERY; ARTIFICIAL DERMIS; INTEGRA; MANAGEMENT; SKIN;
   SUBSTITUTE; EXPERIENCE; MATRIX
AB Degloving injuries are common in trauma and represent a spectrum of complex wounds, the management of which may be highly challenging especially in the paediatric population. In severe injuries leading to wounds reaching tendon and bone, vascularity is compromised precluding traditional wound management, and sometimes necessitating amputation. This report highlights the use of a dermal regeneration template combined with vacuum-assisted closure (VAC) in the treatment of complex traumatic degloving wounds. Here, we present a case of a five-year-old boy who sustained a high-energy shear injury to his lower extremity that resulted in an extensive degloving wound involving the distal third of his leg and the dorsum of his foot.After debridement, the patient underwent VAC combined with a dermal skin substitute placement, followed by split-thickness skin grafting. The extremity healed with no complications and without the need for amputation or flap reconstruction, achieving satisfactory recovery of range of motion and favourable cosmetic results.
C1 [Saab, I. R.; Sarhane, K. A.; Ezzeddine, H. M.; Abu-Sittah, G. S.; Ibrahim, A. E.] Amer Univ Beirut, Dept Surg, Div Plast & Reconstruct Surg, Beirut, Lebanon.
C3 American University of Beirut
RP Saab, IR (通讯作者)，Amer Univ Beirut, Dept Surg, Div Plast & Reconstruct Surg, Beirut, Lebanon.
EM karim.sarhane@yahoo.com
RI Abu-Sittah, Ghassan/AAE-3169-2020; SERHAN, Karim/CAG-5222-2022
OI SERHAN, Karim/0000-0003-4458-4047
CR Corporation I. L., 2010, INTEGRA DERM REG TEM
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NR 30
TC 8
Z9 11
U1 0
U2 9
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2014
VL 23
IS 10
BP S5
EP S8
DI 10.12968/jowc.2014.23.Sup10.S5
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AQ6XZ
UT WOS:000342958500006
PM 25289652
DA 2026-07-24
ER
PT J
AU Takahara, S
   Sai, S
   Kagatani, T
   Konishi, A
AF Takahara, Shingo
   Sai, Sadahiro
   Kagatani, Tomoaki
   Konishi, Akinobu
TI Efficacy and haemodynamic effects of vacuum-assisted closure for
   post-sternotomy mediastinitis in children
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Mediastinal infection; Vacuum-assisted closure; Congenital heart
   disease; Paediatrics; Circulatory haemodynamics
ID PEDIATRIC CARDIAC-SURGERY; POSTOPERATIVE MEDIASTINITIS; NEGATIVE
   PRESSURES; THERAPY; INFECTION; IRRIGATION; EXPERIENCE; SWINE
AB OBJECTIVES: Post-sternotomy mediastinitis is a significant morbidity with controversial management. Vacuum-assisted closure (VAC) has been used to treat mediastinitis, with many reports documenting its efficacy and feasibility, particularly in adults. However, its use is not prevalent in the paediatric population because of concerns that it may deteriorate haemodynamics. This study aimed to evaluate outcomes and effects of VAC on the haemodynamics of paediatric patients with post-sternotomy mediastinitis.
   METHODS: Six patients were treated with VAC between April 2005 and March 2013. We retrospectively investigated their profiles, clinical outcomes and haemodynamic changes, including mean blood pressure (MBP), mean heart rate (MHR), urinary output, amount of diuretics and vasoactive-inotropic score (VIS), before and after VAC initiation.
   RESULTS: The median age and body weight of patients were 6.4 months and 4.5 kg, respectively. Three patients (50%) had single ventricular physiology. The median VAC duration was 12 days. One patient died of pulmonary venous obstruction after mediastinitis was cured. The average MBPs in every 8-h period were examined, and there were no significant changes (P = 0.773); the average MHRs were examined in the same manner and they decreased significantly after initiation of VAC (P = 0.032). Only 2 patients required vasoactive agents. The VIS did not change in 1 patient and decreased in the other. The mean amount of diuretics administered and urinary output per body weight did not change significantly (P = 0.395 and 0.273, respectively).
   CONCLUSIONS: In conclusion, the haemodynamics of children were not significantly affected by the negative pressure of VAC, indicating that this therapy may be safe and effective for post-sternotomy mediastinitis, even in small children with complex cardiac anomalies.
C1 [Takahara, Shingo; Sai, Sadahiro; Kagatani, Tomoaki; Konishi, Akinobu] Miyagi Childrens Hosp, Dept Cardiovasc Surg, Aoba Ku, Sendai, Miyagi 9893126, Japan.
RP Takahara, S (通讯作者)，Miyagi Childrens Hosp, Dept Cardiovasc Surg, Aoba Ku, 4-3-17 Ochiai, Sendai, Miyagi 9893126, Japan.
EM dr_takashin@hotmail.com
RI Takahara, Shingo/AAZ-4640-2021
OI Takahara, Shingo/0000-0002-8363-293X
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NR 22
TC 5
Z9 7
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD OCT
PY 2014
VL 19
IS 4
BP 627
EP 631
DI 10.1093/icvts/ivu234
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AR1CO
UT WOS:000343318800019
PM 25006212
DA 2026-07-24
ER
PT J
AU Bruhin, A
   Ferreira, F
   Chariker, M
   Smith, J
   Runkel, N
AF Bruhin, A.
   Ferreira, F.
   Chariker, M.
   Smith, J.
   Runkel, N.
TI Systematic review and evidence based recommendations for the use of
   Negative Pressure Wound Therapy in the open abdomen
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Negative Pressure Wound Therapy (NPWT); Open abdomen; Temporary
   abdominal closure; Evidence-based recommendations; Systematic review
ID VACUUM-ASSISTED CLOSURE; TEMPORARY ABDOMINAL CLOSURE; DAMAGE-CONTROL
   LAPAROTOMY; MEDIATED FASCIAL TRACTION; DELAYED PRIMARY CLOSURE;
   COMPARTMENT SYNDROME; RETROSPECTIVE EVALUATION; FLUID EVACUATION; TRAUMA
   PATIENTS; VENTRAL HERNIA
AB Introduction: Negative Pressure Wound Therapy (NPWT) is widely used in the management of the open abdomen despite uncertainty regarding several aspects of usage. An expert panel was convened to develop evidence-based recommendations describing the use of NPWT in the open abdomen. Methods: A systematic review was carried out to investigate the efficacy of a range of Temporary Abdominal Closure methods including variants of NPWT. Evidence-based recommendations were developed by an International Expert Panel and graded according to the quality of supporting evidence. Results: Pooled results, in non-septic patients showed a 72% fascial closure rate following use of commercial NPWT kits in the open abdomen. This increased to 82% by the addition of a 'dynamic' closure method. Slightly lower rates were showed with use of Wittmann Patch (68%) and home-made NPWT (vac-pack) (58%). Patients with septic complications achieved a lower rate of fascial closure than non-septic patients but NPWT with dynamic closure remained the best option to achieve fascial closure. Mortality rates were consistent and seemed to be related to the underlying medical condition rather than being influenced by the choice of dressing, Treatment goals for open abdomen were defined prior to developing eleven specific evidence-based recommendations suitable for different stages and grades of open abdomen. Discussion and conclusion: The most efficient temporary abdominal closure techniques are NPWT kits with or without a dynamic closure procedure. Evidence-based recommendations will help to tailor its use in a complex treatment pathway for the individual patient. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
C1 [Bruhin, A.] Dept Trauma & Visceral Surg, Luzern, Switzerland.
   [Ferreira, F.] Hosp Pedro Hispano, Matosinhos Porto, Portugal.
   [Chariker, M.] Aesthet Plast Surg Inst, Louisville, KY USA.
   [Smith, J.] Smith & Nephew, Kingston Upon Hull, N Humberside, England.
   [Runkel, N.] Black Forest Hosp, Dept Gen Surg, Villingen Schwenningen, Germany.
   [Runkel, N.] Univ Freiburg, Freiburg, Germany.
C3 Smith & Nephew; University of Freiburg
RP Smith, J (通讯作者)，101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM jennifer.smith@smith-nephew.com
FU SN; Smith Nephew.
FX S&N provided funding for travel and accommodation for all face-to-face
   expert panel meetings, provided support regarding the published
   literature in NPWT, provided support during the drafting of treatment
   goals and recommendations (author JS) and provided medical writing
   services in preparation of this manuscript (JS). The recommendations
   reflect the independent and unbiased views of the panel and the
   consensus derived during the project and the content of the manuscript
   has not been unfairly influenced by Smith & Nephew. The NPWT-Expert
   Panel was supported by Smith & Nephew.
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NR 111
TC 107
Z9 126
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD OCT
PY 2014
VL 12
IS 10
BP 1105
EP 1114
DI 10.1016/j.ijsu.2014.08.396
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AR4XG
UT WOS:000343588800016
PM 25174789
OA hybrid
DA 2026-07-24
ER
PT J
AU Carassou-Maillan, A
   Savary, D
   Jacquetin, B
AF Carassou-Maillan, A.
   Savary, D.
   Jacquetin, B.
TI Necrotizing fasciitis and double bowel perforation after retropubic
   sub-urethral sling
SO JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION
LA French
DT Article
DE Necrotizing fasciitis; Tension-free vaginal tape (TVT) procedure; Bowel
   perforation; Vacuum-assisted closure system; Retropubic sub-urethral
   sling
AB A 60-year-old woman without medical history developed after a Tension-free Vaginal Tape (TVT) procedure a necrotizing fasciitis and an abscess. After unadapted initial treatment, surgical procedure revealed 2 bowel perforations caused by the sling. Treatment was achieved by total mesh removal, bowel repair, necrosis excision and vacuum-assisted closure system. This is the first case report about the association of necrotizing fasciitis and double bowel perforations after TVT procedure. Any critical sepsis or with unsatisfactory evolution after retropubic sub-urethral sling has to make look for a digestive wound. (c) 2013 Elsevier Masson SAS. All rights reserved.
C1 [Carassou-Maillan, A.; Savary, D.; Jacquetin, B.] CHU Estaing, F-63003 Clermont Ferrand 1, France.
C3 Universite Clermont Auvergne (UCA); CHU Clermont Ferrand
RP Carassou-Maillan, A (通讯作者)，CHU Estaing, 1 Pl Lucie Aubrac, F-63003 Clermont Ferrand 1, France.
EM ananda_carassoumaillan@yahoo.fr
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NR 10
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER MASSON, CORP OFF
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 0368-2315
EI 1773-0430
J9 J GYNECOL OBST BIO R
JI J. Gynecol. Obstet. Biol. Reprod.
PD OCT
PY 2014
VL 43
IS 8
BP 629
EP 632
DI 10.1016/j.jgyn.2013.08.011
PG 4
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA AR6IT
UT WOS:000343688100010
PM 24332737
DA 2026-07-24
ER
PT J
AU Wilkin, G
   Khogali, S
   Garbedian, S
   Slagel, B
   Blais, S
   Gofton, W
   Liew, A
   Renaud, JM
   Papp, S
AF Wilkin, Geoffrey
   Khogali, Shiemaa
   Garbedian, Shawn
   Slagel, Bradley
   Blais, Simon
   Gofton, Wade
   Liew, Allan
   Renaud, Jean-Marc
   Papp, Steven
TI Negative-Pressure Wound Therapy After Fasciotomy Reduces Muscle-Fiber
   Regeneration in a Pig Model
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; RANDOMIZED
   CONTROLLED-TRIAL; SOFT-TISSUE INJURIES; SKELETAL-MUSCLE; COMPARTMENT
   SYNDROME; ISCHEMIA; EXPERIENCE; MANAGEMENT; DEVICE
AB Background: Negative-pressure wound therapy (NPWT) can improve fasciotomy wound closure, but its effects on skeletal muscle are largely unknown. The purpose of this study was to evaluate NPWT effects on skeletal muscle after fasciotomy for compartment syndrome in an animal model and to assess regional variability in muscle fiber regeneration.
   Methods: Compartment syndrome was induced in the hindlimb of twenty-two adult female pigs with use of a continuous intracompartmental serum-infusion model. Fasciotomy was performed after six hours, and animals were randomized to receive either wet-to-dry gauze dressings (control group) or NPWT dressings (2125 mm Hg, continuous suction) for seven days. Delayed primary wound closure was attempted at seven days, and the peroneus tertius was harvested for analysis seven days or twenty-one days after fasciotomy. Muscles were weighed, and hematoxylin and eosin-stained samples from four regions of the muscle (superficial central, deep central, lateral, and proximal) were mapped for different cellular morphologies.
   Results: Muscle weight was greater in the affected limb at all time points with no difference between treatment groups. At seven days, only the deep central samples in the NPWT group had a significantly greater cross-sectional area containing normal fibers as compared with that found in the controls. By twenty-one days, the deep central, lateral, and proximal regions of the NPWT-treated muscles had a smaller cross-sectional area containing normal fiber morphology and a greater cross-sectional area containing only mononucleated cells as compared with the controls.
   Conclusions: NPWT did not decrease muscle weight. At twenty-one days, the extent of muscle fiber regeneration after fasciotomy for compartment syndrome was reduced in muscles treated with NPWT for seven days compared with the values in the control group treated with wet-to-dry gauze dressings.
C1 [Wilkin, Geoffrey; Gofton, Wade; Liew, Allan; Papp, Steven] Univ Ottawa, Div Orthopaed Surg, Ottawa Hosp, Ottawa, ON K1Y 4E9, Canada.
   [Khogali, Shiemaa; Blais, Simon; Renaud, Jean-Marc] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada.
C3 University of Ottawa; Ottawa Hospital Research Institute; University of
   Ottawa
RP Wilkin, G (通讯作者)，Univ Ottawa, Div Orthopaed Surg, Ottawa Hosp, Civ Campus,1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada.
EM geoff.wilkin@gmail.com
RI Wilkin, Geoffrey/KHU-8540-2024
OI Wilkin, Geoffrey/0000-0002-9807-7916
FU KCI Ltd (San Antonio, Texas); Canadian Institutes of Health Research
   (CIHR); Department of Surgery
FX Funding for study materials was provided by grants from KCI Ltd (San
   Antonio, Texas), the Canadian Institutes of Health Research (CIHR), and
   the institution's Department of Surgery. Funding sources had no role in
   designing or conducting the experimental procedures, in drafting the
   manuscript, or in the decision to publish the findings.
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NR 32
TC 14
Z9 19
U1 0
U2 7
PU JOURNAL BONE JOINT SURGERY
PI NEEDHAM
PA 20 PICKERING ST, NEEDHAM, MA 02492 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD AUG 20
PY 2014
VL 96A
IS 16
BP 1378
EP 1385
DI 10.2106/JBJS.M.01010
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA AR8BB
UT WOS:000343799400017
PM 25143498
DA 2026-07-24
ER
PT J
AU Lipsker, A
   Le Roux, F
   Saint, F
   Pignot, G
AF Lipsker, A.
   Le Roux, F.
   Saint, F.
   Pignot, G.
TI Fournier's gangrene: Surgical management
SO PROGRES EN UROLOGIE
LA French
DT Article
ID VACUUM-ASSISTED CLOSURE; THERAPY
AB Introduction. - Perineoscrotal Fournier's gangrene is a rare and acute disease, with pejorative evolution and prognosis. This is an emergency situation requiring a concomitant medical and surgical management.
   Methods. - This article suggests making a clarification on surgical techniques of Fournier's gangrene by integrating the recent data of the literature.
   Results. - The immediate management requires an extensive surgical debridement associated with broad-spectrum antibiotics. After debridement, skin loss can be very damaging and difficult to repair. When general infection has been controlled, the second goal is surgery for skin coverage. The use of vacuum-assisted closure therapy is an alternative to conventional dressings. Finally, plastic surgery could be proposed to guide healing.
   Conclusion. - Extensive debridement, vacuum-assisted closure therapy, and plastic surgery are the keys of surgical management of Fournier's gangrene. (C) 2014 Elsevier Masson SAS. All rights reserved.
C1 [Lipsker, A.; Saint, F.] Univ Picardie, CHU Amiens, Serv Urol Transplant, F-80054 Amiens, France.
   [Le Roux, F.] Univ Picardie, CHU Amiens, Serv Chirurg Digest & Metabol, F-80054 Amiens, France.
   [Pignot, G.] Univ Paris 11, AP HP, Hop Bicetre, Serv Urol, F-94275 Le Kremlin Bicetre, France.
C3 Universite de Picardie Jules Verne (UPJV); CHU Amiens; Universite de
   Picardie Jules Verne (UPJV); CHU Amiens; Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Bicetre - APHP; Universite Paris
   Saclay; Hopital Universitaire Antoine-Beclere - APHP
RP Pignot, G (通讯作者)，Univ Paris 11, AP HP, Hop Bicetre, Serv Urol, 78 Rue Gen Leclerc, F-94275 Le Kremlin Bicetre, France.
EM gg_pignot@yahoo.fr
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bedos JP, 2006, ANN FR ANESTH, V25, P982, DOI 10.1016/j.annfar.2006.03.021
   Cuccia G, 2009, UROL INT, V82, P426, DOI 10.1159/000218532
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NR 14
TC 2
Z9 4
U1 0
U2 3
PU ELSEVIER MASSON, CORP OFF
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1166-7087
EI 2405-5131
J9 PROG UROL
JI Prog. Urol.
PD SEP
PY 2014
VL 24
IS 3
SI SI
BP F80
EP F85
DI 10.1016/j.fpurol.2014.06.001
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AR8RU
UT WOS:000343843000005
DA 2026-07-24
ER
PT J
AU Ko, YS
   Jung, SW
AF Ko, Yoon Song
   Jung, Sung Won
TI Vacuum-assisted close versus conventional treatment for postlaparotomy
   wound dehiscence
SO ANNALS OF SURGICAL TREATMENT AND RESEARCH
LA English
DT Article
DE Vacuum-assisted closure; Dehiscence; Wound
ID INCISIONAL HERNIA; PREVENTION; OPERATIONS; TRAUMA
AB Purpose: The conventional treatment for postlaparotomy wound dehiscence usually involves surgical revision. Recently, vacuum-assisted closure has been successfully used in postlaparotomy wound dehiscence. The aim of the present study was to compare the clinical outcome of 207 patients undergoing vacuum-assisted closure therapy or conventional treatment for postlaparotomy wound dehiscence.
   Methods: Two hundred and seven consecutive patients underwent treatment for postlaparotomy wound dehiscence: vacuum-assisted closure therapy (January 2007 through August 2012, n = 25) or conventional treatment (January 2001 through August 2012, n = 182).
   Results: The failure rate to first-line treatment with vacuum-assisted closure and conventional treatment were 0% and 14.3%, respectively (P = 0.002). There was no statistically significant difference in the enterocutaneous fistulas and hospital stay after vacuum-assisted closure therapy or conventional treatment respectively.
   Conclusion: Our findings support that vacuum-assisted closure therapy is a safe and reliable option in postlaparotomy wound dehiscence with very low failure rate in surgical revision compared with conventional treatment.
C1 [Ko, Yoon Song; Jung, Sung Won] Korea Univ, Coll Med, Anam Hosp, Dept Surg, Seoul 136705, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Jung, SW (通讯作者)，Korea Univ, Coll Med, Anam Hosp, Div HBP Surg & Liver Transplantat,Dept Surg, 73 Inchon Ro, Seoul 136705, South Korea.
EM sungwon94@naver.com
CR Banwell P E, 2003, J Wound Care, V12, P22
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NR 13
TC 4
Z9 5
U1 0
U2 3
PU KOREAN SURGICAL SOCIETY
PI SEOUL
PA 3304HO, 101 DONG, BROWNSTONE SEOUL, 335, JUNGMIN-DONG, JUNG-GU, SEOUL,
   100-859, SOUTH KOREA
SN 2288-6575
EI 2288-6796
J9 ANN SURG TREAT RES
JI Ann. Surg. Treat. Res.
PD NOV
PY 2014
VL 87
IS 5
BP 260
EP 264
DI 10.4174/astr.2014.87.5.260
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AS3UM
UT WOS:000344203500006
PM 25368852
OA hybrid
DA 2026-07-24
ER
PT J
AU McBride, CA
   Stockton, K
   Storey, K
   Kimble, RM
AF McBride, Craig A.
   Stockton, Kellie
   Storey, Kristen
   Kimble, Roy M.
TI Negative pressure wound therapy facilitates closure of large congenital
   abdominal wall defects
SO PEDIATRIC SURGERY INTERNATIONAL
LA English
DT Article
DE Negative pressure wound therapy; Abdominal wall defect; Hernia,
   abdominal; Gastroschisis; Pediatric; Repair
ID GIANT OMPHALOCELE
AB The degree of viscero-abdominal disproportion often makes single-stage reduction difficult in large abdominal wall defects, without risking respiratory or hemodynamic compromise. As a consequence, clinicians have adopted a number of different methods to control these defects. Repair may be in the neonatal period, or later in life. Delayed repairs require epithelialization of the gastroschisis or omphalocele. Definitive repair may be in single or multiple stages. This paper describes four children in whom negative pressure wound therapy (NPWT) was used to facilitate closure of these complex defects.
C1 [McBride, Craig A.; Stockton, Kellie; Storey, Kristen; Kimble, Roy M.] Univ Queensland, Queensland Childrens Med Res Inst, Ctr Childrens Burns & Trauma Res, Brisbane, Qld, Australia.
   [McBride, Craig A.; Stockton, Kellie; Storey, Kristen; Kimble, Roy M.] Childrens Hlth Queensland, Stuart Pegg Paediat Burns Ctr, Brisbane, Qld, Australia.
   [McBride, Craig A.] Univ Queensland, Royal Childrens Hosp, Dept Paediat & Child Hlth, Herston, Qld 4029, Australia.
C3 University of Queensland; Royal Children's Hospital Brisbane; University
   of Queensland
RP McBride, CA (通讯作者)，Univ Queensland, Queensland Childrens Med Res Inst, Ctr Childrens Burns & Trauma Res, Brisbane, Qld, Australia.
EM craig.a.mcbride@gmail.com
RI Stockton, Kellie/F-2423-2015; McBride, Craig/G-4805-2011; Kimble,
   Roy/B-4160-2011
OI Stockton, Kellie/0000-0002-0756-5157; McBride,
   Craig/0000-0001-8377-1748; Kimble, Roy/0000-0002-2449-7707
CR Adetayo OA, 2012, ANN PLAS SURG, V69, P104, DOI 10.1097/SAP.0b013e31822128f5
   Choi WW, 2011, PEDIATR SURG INT, V27, P907, DOI 10.1007/s00383-011-2868-6
   Davies MW, 2002, COCHRANE DB SYST REV, V3, DOI DOI 10.1002/14651858.CD003671
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   Kilbride KE, 2006, J PEDIATR SURG, V41, P212, DOI 10.1016/j.jpedsurg.2005.10.003
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   Levy S, 2013, J PEDIATR SURG, V48, P2525, DOI 10.1016/j.jpedsurg.2013.05.067
   Morris MW, 2013, J PEDIATR SURG, V48, pE13, DOI 10.1016/j.jpedsurg.2013.03.005
   Runkel N, 2011, INJURY, V42, pS1, DOI 10.1016/S0020-1383(11)00041-6
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NR 12
TC 10
Z9 11
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-0358
EI 1437-9813
J9 PEDIATR SURG INT
JI Pediatr. Surg. Int.
PD NOV
PY 2014
VL 30
IS 11
BP 1163
EP 1168
DI 10.1007/s00383-014-3545-3
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA AS5UX
UT WOS:000344335900013
PM 25060123
DA 2026-07-24
ER
PT J
AU Matiasek, J
   Djedovic, G
   Mattesich, M
   Morandi, E
   Pauzenberger, R
   Pikula, R
   Verstappen, R
   Pierer, G
   Koller, R
   Rieger, UM
AF Matiasek, J.
   Djedovic, G.
   Mattesich, M.
   Morandi, E.
   Pauzenberger, R.
   Pikula, R.
   Verstappen, R.
   Pierer, G.
   Koller, R.
   Rieger, U. M.
TI The combined use of NPWT and instillation using an octenidine based
   wound rinsing solution: a case study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy with instillation; octenilin wound
   irrigation solution; pressure ulcer; wound bed preparation, flap
   closure; negative pressure wound therapy
ID RESISTANT STAPHYLOCOCCUS-AUREUS; METHICILLIN-RESISTANT; THERAPY;
   DIHYDROCHLORIDE; FLAP
AB Effective wound bed preparation is an essential element in the healing of chronic wounds, including pressure ulcers (PUs). Negative pressure wound therapy (NPWT) reduces oedema, stimulates the formation of granulation tissue and helps remove wound exudate. This helps prepare the wound bed for secondary healing, skin grafting or coverage with flaps. Combining NPWT with an instillation phase using an antiseptic (octenidine based) irrigation solution is a novel approach to PU management.
   Three patients with Category 4 gluteal PUs were treated with NPWT and instillation fluid, following surgical debridement of necrotic tissue. The aim was to achieve optimal wound bed preparation prior to wound closure by local fasciocutaneous flap.
   The antiseptic efficacy of octenilin wound irrigation solution in microorganism eradication was quantified by in vitro tests simulating real conditions using leg ulcer vacuum exudates.
   All wounds completely healed after four weeks, and no adverse incidents occurred due to instillation of octenidine. No recurrence of the PU occurred during a one year follow-up.
C1 [Matiasek, J.; Koller, R.] Wilhelminenspital Stadt Wien, Dept Plast Aesthet & Reconstruct Surg, Vienna, Austria.
   [Matiasek, J.; Djedovic, G.; Mattesich, M.; Morandi, E.; Pauzenberger, R.; Pikula, R.; Verstappen, R.; Pierer, G.; Rieger, U. M.] Med Univ Innsbruck, Dept Plast Reconstruct & Aesthet Surg, A-6020 Innsbruck, Austria.
   [Rieger, U. M.] St Markus Hosp, Dept Plast & Aesthet Surg Reconstruct & Hand Surg, Frankfurt, Germany.
C3 Wilhelminenspital; Medical University of Innsbruck
RP Matiasek, J (通讯作者)，Wilhelminenspital Stadt Wien, Dept Plast Aesthet & Reconstruct Surg, Vienna, Austria.
OI Verstappen, Ralph/0000-0002-2609-109X; Pauzenberger,
   Reinhard/0000-0001-7146-6260
CR Ahluwalia R, 2009, INT WOUND J, V6, P355, DOI 10.1111/j.1742-481X.2009.00624.x
   [Anonymous], TREATM PRESS ULC QUI
   [Anonymous], 2009, BACT CHALL TIM REACT
   Ashley ESD, 2004, CLIN INFECT DIS, V38, P1555, DOI 10.1086/420819
   Broder K., 2010, WOUNDS, V22, pE13
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   Romanelli M., 2006, SCI PRACTICE PRESSUR
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   Vogt PeterM., 2011, Praxis der Plastischen Chirurgie
NR 28
TC 16
Z9 24
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2014
VL 23
IS 11
BP 590
EP 596
DI 10.12968/jowc.2014.23.11.590
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AS8BK
UT WOS:000344475200009
PM 25375407
DA 2026-07-24
ER
PT J
AU Braun, LR
   Fisk, WA
   Lev-Tov, H
   Kirsner, RS
   Isseroff, RR
AF Braun, Liza R.
   Fisk, Whitney A.
   Lev-Tov, Hadar
   Kirsner, Robert S.
   Isseroff, Roslyn R.
TI Diabetic Foot Ulcer: An Evidence-Based Treatment Update
SO AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
LA English
DT Review
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; OFF-LOADING DEVICES;
   RISK-FACTORS; MANAGEMENT; AMPUTATION; INTERVENTIONS; PREVENTION; HEAL;
   SKIN
AB Background Diabetic foot ulcers (DFUs) are extremely debilitating and difficult to treat. Multidisciplinary management, patient education, glucose control, debridement, offloading, infection control, and adequate perfusion are the mainstays of standard care endorsed by most practice guidelines. Adjunctive therapies represent new treatment modalities endorsed in recent years, though many lack significant high-powered studies to support their use as standard of care.
   Objective This update intends to identify recent, exclusively high level, evidence-based evaluations of DFU therapies. Furthermore, it suggests a direction for future research.
   Methods PubMed, Embase, Ovid Technologies, CI-NAHL, Cochrane, and Web of Science databases were systematically searched for recent systematic reviews published after 2004, and randomized controlled trials published in 2012-2013 that evaluated treatment modalities for DFUs. These papers are reviewed and the quality of available evidence is discussed.
   Results A total of 34 studies met inclusion criteria. Studied therapies include debridement, off-loading, negative pressure therapy, dressings, topical therapies, hyperbaric oxygen therapy, growth factors, bioengineered skin substitutes, electrophysical therapy, and alternative therapy. Good-quality evidence is lacking to justify the use of many of these therapies, with the exception of standard care (offloading, debridement) and possibly negative pressure wound therapy.
   Limitations There is an overall lack of high-level evidence in new adjunctive management of DFU. Comparison of different treatment modalities is difficult, since existing studies are not standardized.
   Conclusions Many therapeutic modalities are available to treat DFU. Quality high-level evidence exists for standard care such as off-loading. Evidence for adjunctive therapies such as negative pressure wound therapy, skin substitutes, and platelet-derived growth factor can help guide adjunctive care but limitations exist in terms of evidence quality.
C1 [Braun, Liza R.; Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
   [Fisk, Whitney A.; Isseroff, Roslyn R.] Univ Calif Davis, Dept Dermatol, Sacramento, CA 95817 USA.
   [Lev-Tov, Hadar] Montefiore Med Ctr, Albert Einstein Coll Med, Div Dermatol, Bronx, NY 10467 USA.
   [Isseroff, Roslyn R.] VA Northern Calif Hlth Care Syst, Mather, CA USA.
C3 University of Miami; University of California System; University of
   California Davis; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University
RP Lev-Tov, H (通讯作者)，Montefiore Med Ctr, Albert Einstein Coll Med, Div Dermatol, Bronx, NY 10467 USA.
EM lhadar1@gmail.com
RI Isseroff, Roslyn/HPH-5753-2023
FU Organogenesis; Shire; KCI
FX No sources of funding were used to prepare this review. Robert Kirsner
   has received consulting fees or honorarium from Organogenesis, Shire,
   and KCI. Dr. Isseroff, Dr. Lev Tov, Ms. Braun, and Ms. Fisk have no
   conflicts of interest that are directly relevant to the content of this
   review.
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NR 69
TC 86
Z9 108
U1 0
U2 51
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-0561
EI 1179-1888
J9 AM J CLIN DERMATOL
JI Am. J. Clin. Dermatol.
PD JUL
PY 2014
VL 15
IS 3
BP 267
EP 281
DI 10.1007/s40257-014-0081-9
PG 15
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AT0BH
UT WOS:000344601300009
PM 24902659
DA 2026-07-24
ER
PT J
AU O'Connor, JV
   DuBose, JJ
   Scalea, TM
AF O'Connor, James V.
   DuBose, Joseph J.
   Scalea, Thomas M.
TI Damage-control thoracic surgery: Management and outcomes
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 72nd Annual Meeting of the
   American-Association-for-the-Surgery-of-Trauma / Clinical Congress of
   Acute Care Surgery
CY SEP 18-23, 2013
CL San Francisco, CA
SP Amer Assoc Surg Trauma
DE Damage control; thoracic trauma; thoracotomy
ID LUNG RESECTION; ABBREVIATED THORACOTOMY; POSTTRAUMATIC EMPYEMA;
   PULMONARY TRACTOTOMY; TRAUMA; INJURY; MORTALITY; PACKING; CLOSURE
AB BACKGROUND: Damage-control surgery is successfully used for severe abdominal trauma. Although the damage-control surgery principles are applicable to thoracic trauma, there is a dearth of data on damage-control thoracic surgery.
   METHODS: This is an institutional review board-approved, retrospective trauma registry study, from January 2002 to December 2012, for thoracic injuries requiring emergency thoracotomy or sternotomy, with temporary closure. Demographics, physiologic and laboratory data, operative procedures, and outcomes were abstracted. Data are presented as mean and SD; Student's t test was used with p < 0.05 conferring statistically significance.
   RESULTS: Forty-four patients were identified, with a median age of 34 years and 86% males. Mean (SD) Injury Severity Score (ISS) was 33.2 (14.7), with 93% having a chest Abbreviated Injury Scale (AIS) score of 3 or greater, 61% having a chest AIS score of 4 or greater, and 32% having a chest AIS score of 5 or greater. Of the patients, 48% had gunshot wounds and 21% had stab wounds. Admission temperature, pH, base deficit, and international normalized ratio were 36 degrees C (1 degrees C), 7.07 (0.13), 11.1 (6.5), and 1.7, respectively. Incisions included anterolateral thoracotomy in 69% and sternotomy in 25%; 73% required pulmonary resection, 20% required cardiorraphy, and 9% had major vascular injuries; multiple procedures were common. Mean intraoperative transfusion was 13 U of packed red blood cells. Forty-two patients (95%) had thoracic packing with vacuum-assisted closure. The thorax was closed when physiology normalized, on a mean (SD) of 3 (1) days. When comparing physiologic parameters at initial operation and chest closure, temperature was 34.4 degrees C (1.3 degrees C) versus 37.4 degrees C (0.8 degrees C), pH was 7.13 (0.14) versus 7.38 (0.6), and international normalized ratio was 1.8 (0.9) versus 1.2 (0.3), respectively, all statistically significantly (p < 0.001). Complications included sepsis (36%), renal failure requiring continuous renal replacement therapy (30%), adult respiratory distress syndrome (25%), and empyema (23%). Six required salvage extracorporeal membrane oxygenation with one survivor. Mortality was 23%. Predictors included higher ISS, renal failure, continuous renal replacement therapy, and extracorporeal membrane oxygenation. All survivors were neurologically intact and dialysis free.
   CONCLUSION: Patients with severe chest trauma and marked physiologic derangement can benefit from damage-control thoracic surgery. Thoracic packing and temporary vacuum closure avoids thoracic compartment syndrome. Timing of thoracic closure is based on physiology. While complications were common, mortality is acceptable in this group of severely injured, metabolically depleted, challenging patients. Copyright (C) 2014 by Lippincott Williams & Wilkins
C1 [O'Connor, James V.] Univ Maryland, Sch Med, Med Ctr, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP O'Connor, JV (通讯作者)，Univ Maryland, Sch Med, Med Ctr, R Adams Cowley Shock Trauma Ctr, 22 S Greene St, Baltimore, MD 21201 USA.
EM joconnor@umm.edu
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NR 30
TC 45
Z9 62
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2014
VL 77
IS 5
BP 660
EP 665
DI 10.1097/TA.0000000000000451
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Surgery
GA AT1OB
UT WOS:000344702300002
PM 25494414
DA 2026-07-24
ER
PT J
AU Karlakki, S
   Brem, M
   Giannini, S
   Khanduja, V
   Stannard, J
   Martin, R
AF Karlakki, S.
   Brem, M.
   Giannini, S.
   Khanduja, V.
   Stannard, J.
   Martin, R.
TI Negative pressure wound therapy for management of the surgical incision
   in orthopaedic surgery A REVIEW OF EVIDENCE AND MECHANISMS FOR AN
   EMERGING INDICATION
SO BONE & JOINT RESEARCH
LA English
DT Article
DE Incisional NPWT; Surgical site infection; Single-use NPWT; NPWT;
   Mechanism of action; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; EVIDENCE-BASED
   RECOMMENDATIONS; HIGH-RISK PATIENTS; SUBATMOSPHERIC PRESSURE;
   INTERNATIONAL CONSENSUS; SITE INFECTIONS; CARDIAC-SURGERY;
   LOWER-EXTREMITY; PREVENTION
AB Objectives
   The period of post-operative treatment before surgical wounds are completely closed remains a key window, during which one can apply new technologies that can minimise complications. One such technology is the use of negative pressure wound therapy to manage and accelerate healing of the closed incisional wound (incisional NPWT).
   Methods
   We undertook a literature review of this emerging indication to identify evidence within orthopaedic surgery and other surgical disciplines. Literature that supports our current understanding of the mechanisms of action was also reviewed in detail.
   Results
   A total of 33 publications were identified, including nine clinical study reports from orthopaedic surgery; four from cardiothoracic surgery and 12 from studies in abdominal, plastic and vascular disciplines. Most papers (26 of 33) had been published within the past three years. Thus far two randomised controlled trials - one in orthopaedic and one in cardiothoracic surgery - show evidence of reduced incidence of wound healing complications after between three and five days of post-operative NPWT of two- and four-fold, respectively. Investigations show that reduction in haematoma and seroma, accelerated wound healing and increased clearance of oedema are significant mechanisms of action.
   Conclusions
   There is a rapidly emerging literature on the effect of NPWT on the closed incision. Initiated and confirmed first with a randomised controlled trial in orthopaedic trauma surgery, studies in abdominal, plastic and vascular surgery with high rates of complications have been reported recently. The evidence from single-use NPWT devices is accumulating. There are no large randomised studies yet in reconstructive joint replacement.
C1 [Karlakki, S.] Robert Jones Agnes Hunt Orthopaed Hosp, Arthroplasty Dept, Oswestry SY10 7AG, Shrops, England.
   [Brem, M.] Univ Erlangen Nurnberg, Klinikum Nuernberg, Dept Orthopaed & Trauma Surg, D-90419 Nurnberg, Germany.
   [Giannini, S.] Ist Ortoped Rizzoli, I-40136 Bologna, Italy.
   [Khanduja, V.] Addenbrookes Hosp, Dept Trauma & Orthopaed, Cambridge CB2 0QQ, England.
   [Stannard, J.] Univ Missouri, Missouri Orthopaed Inst, Dept Orthopaed Surg, Columbia, MO 65212 USA.
   [Martin, R.] Smith & Nephew Ltd, Adv Wound Devices, Adv Wound Management Div, Kingston Upon Hull HU3 2BN, N Humberside, England.
C3 Keele University; Klinikum Nurnberg; University of Erlangen Nuremberg;
   IRCCS Istituto Ortopedico Rizzoli; Cambridge University Hospitals NHS
   Foundation Trust; Addenbrooke's Hospital; University of Cambridge;
   University of Missouri System; University of Missouri Columbia; Smith &
   Nephew
RP Martin, R (通讯作者)，Robert Jones Agnes Hunt Orthopaed Hosp, Oswestry, Shrops, England.
EM robin.martin@smith-nephew.com
RI Khanduja, Vikas/U-9318-2017
OI Khanduja, Vikas/0000-0001-9454-3978; Martin, Robin/0000-0002-9314-0437
FU Smith Nephew
FX The authors are members of an Expert Panel on incisional NPWT in
   orthopaedic surgery funded by Smith & Nephew. R. Martin is an employee
   of Smith & Nephew.
CR [Anonymous], DZF
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NR 67
TC 98
Z9 115
U1 0
U2 11
PU BRITISH EDITORIAL SOC BONE JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2046-3758
J9 BONE JOINT RES
JI Bone Jt. Res.
PD DEC
PY 2013
VL 2
IS 12
BP 276
EP 284
DI 10.1302/2046-3758.212.2000190
PG 9
WC Cell & Tissue Engineering; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Orthopedics
GA AT2JP
UT WOS:000344761200004
PM 24352756
OA gold
DA 2026-07-24
ER
PT J
AU Glass, GE
   Murphy, GF
   Esmaeili, A
   Lai, LM
   Nanchahal, J
AF Glass, G. E.
   Murphy, G. F.
   Esmaeili, A.
   Lai, L. -M.
   Nanchahal, J.
TI Systematic review of molecular mechanism of action of negative-pressure
   wound therapy
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; ENDOTHELIAL GROWTH-FACTOR; MATRIX
   METALLOPROTEINASES; GENE-EXPRESSION; SHEAR-STRESS; TNF-ALPHA; EGR-1;
   HYPOXIA; INTERLEUKIN-8; TRANSCRIPTION
AB BackgroundNegative-pressure wound therapy (NPWT) promotes angiogenesis and granulation, in part by strain-induced production of growth factors and cytokines. As their expression profiles are being unravelled, it is pertinent to consider the mode of action of NPWT at the molecular level.
   MethodsMEDLINE (January 1997 to present), Embase (January 1997 to present), PubMed (no time limit), the Cochrane Database of Systematic Reviews and the Cochrane Controlled Trials Register were searched for articles that evaluated the influence of NPWT on growth factor expression quantitatively.
   ResultsSixteen studies met the inclusion criteria. Tumour necrosis factor expression was reduced in acute and chronic wounds, whereas expression of interleukin (IL) 1 was reduced in acute wounds only. Systemic IL-10 and local IL-8 expression were increased by NPWT. Expression of vascular endothelial growth factor, fibroblast growth factor 2, transforming growth factor and platelet-derived growth factor was increased, consistent with mechanoreceptor and chemoreceptor transduction in response to stress and hypoxia. Matrix metalloproteinase-1, -2, -9 and -13 expression was reduced but there was no effect on their enzymatic inhibitor, tissue inhibitor of metalloproteinase 1.
   ConclusionCytokine and growth factor expression profiles under NPWT suggest that promotion of wound healing occurs by modulation of cytokines to an anti-inflammatory profile, and mechanoreceptor and chemoreceptor-mediated cell signalling, culminating in angiogenesis, extracellular matrix remodelling and deposition of granulation tissue. This provides a molecular basis for understanding NPWT.
   How the vacuum works
C1 [Glass, G. E.; Nanchahal, J.] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford OX3 7FY, England.
   [Murphy, G. F.] Univ Oxford, St Hughs Coll, Oxford OX3 7FY, England.
   [Glass, G. E.; Murphy, G. F.; Esmaeili, A.] Royal Free Hosp, Dept Plast Surg, London NW3 2QG, England.
   [Lai, L. -M.] Royal Free Hosp, Dept Gen & Breast Surg, London NW3 2QG, England.
   [Lai, L. -M.] St Albans Hosp, Dept Gen Surg, St Albans, Herts, England.
C3 University of Oxford; Kennedy Institute for Rheumatology; University of
   Oxford; University of London; University College London; UCL Medical
   School; Royal Free London NHS Foundation Trust; University of London;
   University College London; UCL Medical School; Royal Free London NHS
   Foundation Trust
RP Glass, GE (通讯作者)，Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Roosevelt Dr, Oxford OX3 7FY, England.
EM graeme.glass@ndorms.ox.ac.uk
RI ; Glass, Graeme/I-7011-2019
OI Esmaeili, Ali/0009-0003-5280-2574; Nanchahal,
   Jagdeep/0000-0002-9579-9411
FU Academy of Medical Sciences (AMS) [AMS-SGCL6-Glass] Funding Source:
   researchfish
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NR 60
TC 176
Z9 214
U1 0
U2 37
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD DEC
PY 2014
VL 101
IS 13
BP 1627
EP 1636
DI 10.1002/bjs.9636
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AT2WI
UT WOS:000344794500002
PM 25294112
OA Bronze
DA 2026-07-24
ER
PT J
AU Salica, A
   Weltert, L
   Scaffa, R
   Guerrieri, L
   Nardella, S
   Bellisario, A
   De Paulis, R
AF Salica, Andrea
   Weltert, Luca
   Scaffa, Raffaele
   Guerrieri, Lorenzo
   Nardella, Saverio
   Bellisario, Alessandro
   De Paulis, Ruggero
TI Negative pressure wound treatment improves Acute Physiology and Chronic
   Health Evaluation II score in mediastinitis allowing a successful
   elective pectoralis muscle flap closure: Six-year experience of a single
   protocol
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; CARDIAC-SURGERY;
   POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS; BLOOD-FLOW; INFECTION;
   COMPLICATIONS; THERAPY; DEBRIDEMENT
AB Objectives: Optimal management of poststernotomy mediastinitis is controversial. Negative pressure wound treatment improves wound environment and sternal stability with low surgical invasiveness. Our protocol was based on negative pressure followed by delayed surgical closure. The aim of this study was to provide the results at early follow-up and to identify the risk factors for adverse outcome.
   Methods: In 5400 cardiac procedures, 44 consecutive patients with mediastinitis were enrolled in the study. Mediastinitis treatment was based on urgent debridement and negative pressure as the first-line approach. After wound sterilization, chest closure was achieved by elective pectoralis muscle advancement flap. Each patient's hospital data were collected prospectively. Variables included patient demographics and clinical and biological data. Acute Physiology and Chronic Health Evaluation (APACHE) II score was calculated at the time of diagnosis and 48 hours after debridement. Focus outcome measures were mediastinitis-related death and need for reintervention after pectoralis muscle closure.
   Results: El Oakley type I and type IIIA mediastinitis were the most frequent types (63.6%). Methicillin-resistant Staphylococcus aureus was present in 25 patients (56.8%). Mean APACHE II score was 19.4 +/- 4 at the time of diagnosis, and 30 patients (68.2%) required intensive care unit transfer before surgical debridement. APACHE II score improved 48 hours after wound debridement and negative pressure application (mean value, 19.4 +/- 4 vs 7.2 +/- 2; P = .005) independently of any other variables included in the study. One patient in septic shock at the time of diagnosis died (2.2%).
   Conclusions: Negative pressure promotes a significant improvement in clinical status according to APACHE II score and allows a successful elective surgical closure.
C1 [Salica, Andrea; Weltert, Luca; Scaffa, Raffaele; Guerrieri, Lorenzo; Nardella, Saverio; Bellisario, Alessandro; De Paulis, Ruggero] European Hosp, Dept Cardiac Surg, I-00149 Rome, Italy.
RP De Paulis, R (通讯作者)，European Hosp, Div Cardiac Surg, Via Portuense 700, I-00149 Rome, Italy.
EM depauli@tin.it
RI Salica, Andrea/GSN-3794-2022; De Paulis, Ruggero/P-2408-2015; Scaffa,
   Raffaele/GRJ-8591-2022
OI WELTERT, Luca Paolo/0000-0001-6094-8280; De Paulis,
   Ruggero/0000-0002-3603-2202; Scaffa, Raffaele/0000-0002-9048-631X
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NR 30
TC 8
Z9 10
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD NOV
PY 2014
VL 148
IS 5
BP 2397
EP 2403
DI 10.1016/j.jtcvs.2014.04.025
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AT7QM
UT WOS:000345132600129
PM 24836724
OA Bronze
DA 2026-07-24
ER
PT J
AU Biter, LU
   Beck, GMN
   Mannaerts, GHH
   Stok, MM
   van der Ham, AC
   Grotenhuis, BA
AF Biter, L. Ulas
   Beck, Guyon M. N.
   Mannaerts, Guido H. H.
   Stok, Myrte M.
   van der Ham, Arie C.
   Grotenhuis, Brechtje A.
TI The Use of Negative-Pressure Wound Therapy in Pilonidal Sinus Disease: A
   Randomized Controlled Trial Comparing Negative-Pressure Wound Therapy
   Versus Standard Open Wound Care After Surgical Excision
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE Pilonidal sinus disease; Vacuum therapy; Negative pressure wound
   therapy; Wound care; Wound size reduction; Surgical excision
ID VACUUM-ASSISTED CLOSURE; METAANALYSIS; SURGERY
AB BACKGROUND: Pilonidal sinus disease is associated with significant morbidity after surgical treatment with regard to wound healing. Recent case studies suggested that negative-pressure wound therapy as primary treatment following surgical excision may shorten the duration of wound healing.
   OBJECTIVE: The purpose of this randomized controlled trial was to evaluate the role of vacuum therapy in pilonidal sinus disease: negative-pressure wound therapy versus standard open wound care after surgical excision.
   METHODS: Patients were randomly assigned to either negative-pressure wound therapy for 2 weeks or standard open wound healing. The primary end point of the study was the time to complete wound healing. Secondary end points were visual analog scale score, wound size ratio at day 14 (ie, wound healing rate), time to resume daily activities, and recurrence within 6 months after wound closure.
   RESULTS: Forty-nine patients were included in the study: 24 patients were treated with vacuum therapy, and 25 patients underwent standard open wound care. Complete wound healing was achieved at a median of 84 days in the vacuum therapy group versus 93 days in control patients (p = 0.44). The wound size ratio was significantly lower in the vacuum therapy group (0.30 versus 0.57, p = 0.02), ie, higher wound healing rate in the first 2 weeks. There was no difference in visual analog scale scores and disease recurrence between both groups. The time to resume full daily activities after surgery was 27 days in the patients undergoing vacuum therapy and 29 days in the control patients (p = 0.92).
   LIMITATIONS: This study is limited by the small number of patients, the lack of blinding to patients and doctors, and the absence of patient quality-of-life evaluation.
   CONCLUSION: It is feasible to apply vacuum therapy in the treatment of pilonidal sinus disease, and it has a positive effect on wound size reduction in the first 2 weeks. However, there is no difference in time to complete wound healing and time to resume daily life activities.
C1 [Biter, L. Ulas; Beck, Guyon M. N.; Mannaerts, Guido H. H.; Stok, Myrte M.; van der Ham, Arie C.; Grotenhuis, Brechtje A.] St Franciscus Gasthuis, Dept Surg, NL-3004 BA Rotterdam, Netherlands.
C3 Franciscus Gasthuis
RP Biter, LU (通讯作者)，St Franciscus Gasthuis, Dept Surg, POB 10900, NL-3004 BA Rotterdam, Netherlands.
EM u.biter@sfg.nl
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NR 18
TC 57
Z9 69
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD DEC
PY 2014
VL 57
IS 12
BP 1406
EP 1411
DI 10.1097/DCR.0000000000000240
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA AT8BF
UT WOS:000345158100015
PM 25380007
DA 2026-07-24
ER
PT J
AU Adogwa, O
   Fatemi, P
   Perez, E
   Moreno, J
   Gazcon, GC
   Gokaslan, ZL
   Cheng, J
   Gottfried, O
   Bagley, CA
AF Adogwa, Owoicho
   Fatemi, Parastou
   Perez, Edgar
   Moreno, Jessica
   Gazcon, Gustavo Chagoya
   Gokaslan, Ziya L.
   Cheng, Joseph
   Gottfried, Oren
   Bagley, Carlos A.
TI Negative pressure wound therapy reduces incidence of postoperative wound
   infection and dehiscence after long-segment thoracolumbar spinal fusion:
   a single institutional experience
SO SPINE JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Deformity; Wound dehiscence; Wound
   infection; Spine outcomes; Surgical site infections
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; LUMBAR SPINE;
   SURGERY; DUROTOMY; MULTICENTER; PREVENTION; ULCERS; STATE
AB BACKGROUND CONTEXT: Wound dehiscence and surgical site infections (SSIs) can have a profound impact on patients as they often require hospital readmission, additional surgical interventions, lengthy intravenous antibiotic administration, and delayed rehabilitation. Negative pressure wound therapy (NPWT) exposes the wound site to negative pressure, resulting in the improvement of blood supply, removal of excess fluid, and stimulation of cellular proliferation of granulation tissue.
   PURPOSE: To assess the incidence of wound infection and dehiscence in patients undergoing long-segment thoracolumbar fusion before and after the routine use of NPWT.
   STUDY DESIGN: Retrospective study.
   PATIENT SAMPLE: One hundred sixty patients undergoing long-segment thoracolumbar spine fusions were included in this study.
   OUTCOME MEASURES: Postoperative incidence of wound infection and dehiscence.
   METHODS: All adult patients undergoing thoracolumbar fusion for spinal deformity over a 6-year period at Duke University Medical Center by the senior author (CB) were included in this study. In 2012, a categorical change was made by the senior author (CB) that included the postoperative routine use of incisional NPWT devices after primary wound closure in all long-segment spine fusions. Before 2012, NPWT was not used. After primary wound closure, a negative pressure device is contoured to the size of the incision and placed over the incision site for 3 postoperative days. We retrospectively review the first 46 cases in which NPWT was used and compared them with the immediately preceding 114 cases to assess the incidence of wound infection and dehiscence.
   RESULTS: One hundred sixty (NPWT: 46 cases, non-NPWT: 114 cases) long-segment thoracolumbar spine fusions were performed for deformity correction. Baseline characteristics were similar between both cohorts. Compared with the non-NPWT cohort, a 50% decrease in the incidence of wound dehiscence was observed in the NPWT patient cohort (6.38% vs. 12.28%, p=.02). Similarly, compared with the non-NPWT cohort, the incidence of postoperative SSIs was significantly decreased in the NPWT cohort (10.63% vs. 14.91%, p=.04).
   CONCLUSIONS: Routine use of incisional NPWT was associated with a significant reduction in the incidence of postoperative wound infection and dehiscence. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Adogwa, Owoicho; Fatemi, Parastou; Perez, Edgar; Moreno, Jessica; Gazcon, Gustavo Chagoya; Gottfried, Oren; Bagley, Carlos A.] Duke Univ, Med Ctr, Div Neurosurg, Durham, NC 27710 USA.
   [Gokaslan, Ziya L.] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD USA.
   [Cheng, Joseph] Vanderbilt Univ, Med Ctr, Dept Neurosurg, Nashville, TN 37232 USA.
C3 Duke University; Johns Hopkins University; Vanderbilt University
RP Adogwa, O (通讯作者)，DUMC, Box 3807, Durham, NC 27710 USA.
EM owoicho.adogwa@gmail.com
RI Moreno, Jessica/AAV-1030-2021; Chagoya, Gustavo/S-8172-2019
OI Chagoya, Gustavo/0000-0002-8337-4467
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NR 24
TC 89
Z9 96
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1529-9430
EI 1878-1632
J9 SPINE J
JI Spine Journal
PD DEC
PY 2014
VL 14
IS 12
BP 2911
EP 2917
DI 10.1016/j.spinee.2014.04.011
PG 7
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA AU2EQ
UT WOS:000345429500020
PM 24769401
DA 2026-07-24
ER
PT J
AU Hayn, E
AF Hayn, Ernesto
TI Successful treatment of complex traumatic and surgical wounds with a
   foetal bovine dermal matrix
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Dermal repair; Plastic surgery; Reconstructive surgery; Trauma; Wound
   healing
ID BIOENGINEERED SKIN; COVERAGE
AB A foetal bovine dermal repair scaffold (PriMatrix, TEI Biosciences) was used to treat complex surgical or traumatic wounds where the clinical need was to avoid skin flaps and to build new tissue in the wound that could be reepithelialised from the wound margins or closed with a subsequent application of a split-thickness skin graft (STSG). Forty-three consecutive cases were reviewed having an average size of 793 cm(2), 50% of which had exposed tendon and/or bone. In a subset of wounds (447%), the implantation of the foetal dermal collagen scaffold was also augmented with negative pressure wound therapy (NPWT). Complete wound healing was documented in over 80% of the wounds treated, whether the wound was treated with the foetal bovine dermal scaffold alone (952%) or when supplemented with NPWT (824%). The scaffold successfully incorporated into wounds with exposed tendon and/or bone to build vascularised, dermal-like tissue. The new tissue in the wound supported STSGs however, in the majority of the cases (883%); wound closure was achieved through reepithelialisation of the incorporated dermal scaffold by endogenous wound keratinocytes. The foetal bovine dermal repair scaffold was found to offer an effective alternative treatment strategy for definitive closure of challenging traumatic or surgical wounds on patients who were not suitable candidates for tissue flaps.
C1 Plast Surg Palm Beach, Wellington, FL 33414 USA.
RP Hayn, E (通讯作者)，Plast Surg Palm Beach, 10115 W Forest Hill Blvd,400, Wellington, FL 33414 USA.
EM Docehayn@gmail.com
CR Cornwell Kevin G, 2009, Clin Podiatr Med Surg, V26, P507, DOI 10.1016/j.cpm.2009.08.001
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NR 19
TC 26
Z9 29
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2014
VL 11
IS 6
BP 675
EP 680
DI 10.1111/iwj.12028
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AU3JS
UT WOS:000345509700018
PM 23452161
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Timmons, J
   Russell, F
AF Timmons, John
   Russell, Fiona
TI The use of negative-pressure wound therapy to manage enteroatmospheric
   fistulae in two patients with large abdominal wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Enteroatmospheric fistulae; Fistulae; Negative pressure; Open abdomen
ID INTRAABDOMINAL HYPERTENSION; COMPARTMENT SYNDROME; CLOSURE
AB Enteric fistulae are a relatively common complication of bowel surgery or in surgery where the bowel has been exposed. Fistulae can present a significant threat to patients' well-being. Changes in surgical techniques and in particular the rise in damage control surgery for emergency patients have led to an increase in open abdominal wounds. The presence of an enteroatmospheric fistula on the surface of a wound can cause a number of distressing symptoms/issues for the patient whilst providing a significant challenge for the clinician. The loss of fluid, proteins and electrolytes will place the patient in danger of becoming hypokalaemic and malnourished. A variety of techniques are available, most refer to a method of isolating the fistula using stoma rings or washers and ostomy paste. The role of negative pressure in the management of wounds with fistula is in its infancy; however, there is evidence to suggest that isolation techniques can be advantageous in managing wounds with fistulae.
C1 [Timmons, John] Smith & Nephew Healthcare, Wound Care, Kingston Upon Hull, Yorks, England.
   [Timmons, John; Russell, Fiona] Aberdeen Royal Infirm, Dept Tissue Viabil, Aberdeen, Scotland.
C3 Smith & Nephew; University of Aberdeen
RP Timmons, J (通讯作者)，Smith & Nephew Healthcare, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM john.timmons@smith-nephew.com
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NR 11
TC 11
Z9 12
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2014
VL 11
IS 6
BP 723
EP 729
DI 10.1111/iwj.12038
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AU3JS
UT WOS:000345509700025
PM 23490208
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Buchanan, PJ
   Kung, TA
   Cederna, PS
AF Buchanan, Patrick J.
   Kung, Theodore A.
   Cederna, Paul S.
TI Evidence-Based Medicine: Wound Closure
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID FREE-TISSUE TRANSFER; VACUUM-ASSISTED CLOSURE; CIGARETTE-SMOKING;
   SKIN-GRAFTS; BACTERIAL INOCULATION; RECONSTRUCTIVE LADDER; PERFORATOR
   FLAP; BLOOD-FLOW; THERAPY; SURGERY
AB Learning Objectives: After reading this article, the participant should be able to: 1. Describe various wound closure techniques available to the modern plastic surgeon, including the indications and contraindications of each. 2. Explain the fundamental concepts of wound healing as it relates to reconstruction. 3. Understand the role of commonly used reconstructive adjuncts such as negative-pressure wound therapy, dermal substitutes, and tissue expansion. 4. Assess the important patient factors that may influence the strategy for surgical wound closure.
   Summary: Successful wound closure requires a comprehensive approach that includes consideration of suitable surgical techniques and critical patient factors. A clear understanding of key concepts such as wound healing, flap design, and patient risk assessment is imperative to a favorable outcome. In this Maintenance of Certification/Continuing Medical Education article, the reader is provided a summary of the available surgical options for wound closure and a discussion of the algorithm used to choose the most appropriate reconstructive strategy.
C1 [Buchanan, Patrick J.; Kung, Theodore A.; Cederna, Paul S.] Univ Michigan Hlth Syst, Dept Surg, Sect Plast & Reconstruct Surg, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Cederna, PS (通讯作者)，Univ Michigan Hlth Syst, Dept Surg, Sect Plast & Reconstruct Surg, 1500 East Med Ctr Dr 2130 Taubman Ctr,SPC 5340, Ann Arbor, MI 48109 USA.
EM cederna@med.umich.edu
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NR 95
TC 40
Z9 45
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2014
VL 134
IS 6
BP 1391
EP 1404
DI 10.1097/PRS.0000000000000720
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AU3WL
UT WOS:000345541400031
PM 25415102
DA 2026-07-24
ER
PT J
AU Qiu, B
   Peng, F
   Zhong, J
   Wang, Z
AF Qiu, Bo
   Peng, Fei
   Zhong, Jun
   Wang, Zhe
TI Effect of Negative Pressure Wound Therapy and External Fixation in the
   Treatment of Femur Fracture Complicated by Skin Avulsion: A
   Retrospective Case Series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; external fixation; femoral fracture;
   soft tissue avulsion
AB Objective. The purpose of this study is to explore the clinical effects of negative pressure wound therapy (NPWT) and external fixation in the treatment of femur fracture complicated by skin avulsion. Materials and Methods. Seven cases of comminuted fracture of the femur caused by traffic accidents and complicated by skin avulsion were retrospectively analyzed. After stabilization and treatment of life-threatening injuries, these 7 patients underwent wound debridement, external fixation of the fracture, and coverage of the wound with NPWT. Secondarily, the wounds were covered by skin-grafting. Patients were followed for an average of 12 months. Results. After infection prophylaxis had been implemented and healthy granulation tissue had developed, each patient underwent secondary suture, free-skin grafting, or skin flap transfer. No wound had purulent drainage upon removal of the NPWT 4 to 7 days after placement. Secondary skin grafting was accomplished successfully in all 7 patients. Patients were followed for 6 to 15 months, and all wounds were well healed with no case of nonunion, osteomyelitis, or deformity at the site of union. Conclusion. External fixation with NPWT is effective treatment for femur fracture complicated by skin avulsion. The rate of infection is low and hospital stay is relatively short.
C1 [Qiu, Bo; Peng, Fei; Zhong, Jun; Wang, Zhe] Wuhan Univ, Renmin Hosp, Dept Orthoped, Hubei 430060, Peoples R China.
C3 Wuhan University
RP Qiu, B (通讯作者)，Wuhan Univ, Renmin Hosp, Dept Orthoped, 99 Zhangzhidong Rd, Wuhan 430060, Peoples R China.
EM drqb123@163.com
CR [Anonymous], OSTOMY WOUND MANAG S
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NR 13
TC 1
Z9 1
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2014
VL 26
IS 10
BP 280
EP 284
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AW2OZ
UT WOS:000346129200002
PM 25855992
DA 2026-07-24
ER
PT J
AU Koenen, W
   Kunte, C
AF Koenen, W.
   Kunte, C.
TI Dermatologic surgery on the scalp
SO HAUTARZT
LA German
DT Article
DE Soft tissue defects; Skull bone; Vacuum assisted closure; Dermal skin
   substitutes; Complications
ID OUTER TABLE; DEFECTS; RECONSTRUCTION; COVERAGE; CLOSURE; GRAFTS; WOUNDS;
   SKULL; BONE
AB Soft tissue defects of the scalp can be closed with varying techniques depending on size and depth of the defect. While small and superficial defects can be closed primarily or be left open for secondary intention healing, larger and deeper defects may need flaps or skin grafts. Extensive defects may require combined flaps or vacuum assisted closure techniques. Defects of the periosteum with denuded skull bone must be treated immediately to avoid bony complications. Usually, the tabula externa is fenestrated with holes or abraded totally to create better healing conditions. Granulation tissue may be induced on the properly prepared skull with vacuum-assisted closure, by using collagen sheets or with dermal skin substitutes. New developments in tissue engineering will surely provide new techniques for dealing with deep and extensive soft tissue defects.
C1 [Koenen, W.] Dermatol Fronhof, D-67098 Bad Durkheim, Germany.
   [Kunte, C.] Artemed Fachklin, Abt Dermatol & Dermatochirurg, Munich, Germany.
RP Koenen, W (通讯作者)，Dermatol Fronhof, Fronhofallee 1, D-67098 Bad Durkheim, Germany.
EM w.koenen@gmx.de
RI Koenen, Wolfgang/NUP-5484-2025
OI Kunte, Christian/0000-0002-3220-9816
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NR 18
TC 4
Z9 5
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0017-8470
EI 1432-1173
J9 HAUTARZT
JI Hautarzt
PD DEC
PY 2014
VL 65
IS 12
BP 1037
EP 1042
DI 10.1007/s00105-014-3533-5
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AW3CZ
UT WOS:000346164400008
PM 25394521
DA 2026-07-24
ER
PT J
AU Schröder, W
   Leers, JM
   Bludau, M
   Herbold, T
   Holscher, AH
AF Schroeder, W.
   Leers, J. M.
   Bludau, M.
   Herbold, T.
   Holscher, A. H.
TI Perforations near the cardia in benign diseases
SO CHIRURG
LA German
DT Article
DE Esophageal perforation; Boerhaave syndrome; Endoscopic stenting; Vacuum
   assisted closure; Esophagectomy
ID ESOPHAGEAL-PERFORATION; ANASTOMOTIC LEAK; COMPUTED-TOMOGRAPHY; CONTRAST
   SWALLOW; MANAGEMENT; IMPACT; SURGERY; OPTIONS; CLOSURE; ADULTS
AB Esophageal perforations nearby the cardia are a clinical disorder of various causes. Perforations occur most often following diagnostic or interventional endoscopy but spontaneous perforations (Boerhaave syndrome) are less frequent. Due to the heterogeneous etiology there is a broad range of therapeutic options. In most cases the esophageal perforation site can be covered by an endoscopic stent. Recent endoscopic procedures are the intraluminal application of an endoscopic vacuum-assisted closure system (endo-VAC) or clipping of the esophageal defect. Surgical procedures include direct suturing with external coverage of the defect or transhiatal blunt dissection of the esophagus without primary reconstruction. All endoscopic and surgical procedures often require an additional drainage of the mediastinum and if necessary of the thoracic and abdominal cavities. The clinical presentation ranges from a simple perforation without concomitant esophageal pathology to a defect of considerable length with pleural perforation and associated septic multiple organ failure. The severity of the septic course is the crucial parameter for the choice of the procedure. An early multiple organ failure indicates an insufficient drainage of the septic focus and is indicative for surgical resection. The overall mortality is given as 12 % in the current literature and primarily depends on the localization and the etiology of the perforation. The highest mortality rates are observed with Boerhaave syndrome. The most important prognostic variable is the time interval between perforation and initiation of therapy whereby the mortality rises up to 20 % if the interval exceeds 24 h. Due to the complex therapy and the poor prognosis esophageal perforations should be treated in specialized centers.
C1 [Schroeder, W.; Leers, J. M.; Bludau, M.; Herbold, T.; Holscher, A. H.] Univ Klin Koln, Klin Allgemein Viszeral & Tumorchirurg, D-50937 Cologne, Germany.
C3 University of Cologne
RP Schröder, W (通讯作者)，Univ Klin Koln, Klin Allgemein Viszeral & Tumorchirurg, Kerpener Str 62, D-50937 Cologne, Germany.
EM wolfgang.schroeder@uni-koeln.de
RI /AAP-2598-2021; Schröder, Wolfgang/A-8799-2008
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NR 19
TC 5
Z9 5
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD DEC
PY 2014
VL 85
IS 12
BP 1064
EP +
DI 10.1007/s00104-014-2805-z
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AW3ES
UT WOS:000346169400004
PM 25488114
DA 2026-07-24
ER
PT J
AU Schorsch, T
   Müller, C
   Loske, G
AF Schorsch, T.
   Mueller, C.
   Loske, G.
TI Endoscopic vacuum therapy of perforations and anastomotic insufficiency
   of the esophagus
SO CHIRURG
LA German
DT Article
DE Postoperative complications; Treatment outcome; Retrospective studies;
   Wound healing; Negative pressure wound therapy
ID ASSISTED CLOSURE; MANAGEMENT; LEAKAGE; ESOPHAGECTOMY; OPTIONS;
   COMPLICATIONS; RESECTION; STENT
AB The high morbidity and mortality of esophageal defects show that the clinical challenge in the treatment of this disease still remains. An innovative method which has been developed in recent years for esophageal leakage is endoscopic vacuum therapy.
   A retrospective analysis of all patients treated for esophageal perforation with endoscopic vacuum therapy in our department was carried out.
   From November 2006 to October 2013 a total of 35 patients were treated with this method and of these 21 had anastomotic leakage, 7 had iatrogenic perforation due to flexible or rigid endoscopy and 7 patients had esophageal defects of various other origins. Drainage systems with an open pore polyurethane tip were placed using a standard endoscope. The vacuum drainage may be positioned either in the esophageal lumen onto the defect or through the defect into the extraluminal wound cavity. The intraluminal or intracavitary vacuum drainage is connected to an electronically controlled vacuum device and a continuous negative pressure of 125 mmHg is maintained for several days. The esophageal lumen or wound cavity collapses around the drainage resulting in intraluminal evacuation and closure of the defect. Under endoscopic monitoring the vacuum system is changed regularly until stable secondary healing of the intracorporeal wound or closure of the transmural defect is achieved.
   In 32 out of 35 patients (91.4 %) healing of defects was achieved after median treatment duration of 11 days (range 4-78 days). The postoperative anastomotic leakage healed in 20 out of 21 patients (95.2 %) after a median of 11 days (range 4-46 days) of therapy. The defects in the 7 patients who were treated for iatrogenic perforation all healed (100 %) after a median treatment time of 5 days (range 4-7 days). There was one case of a recurrent fistula 75 days after treatment. The 90-day mortality in this series of 35 patients was 5.7 %.
   The results of this retrospective study emphasize the increasing importance of endoscopic vacuum therapy in the current literature as an endoscopic treatment method in the management of esophageal perforation and anastomotic leakage.
C1 [Schorsch, T.; Mueller, C.; Loske, G.] Kathol Marienkrankenhaus GmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, D-22087 Hamburg, Germany.
C3 St. Marien Hospital
RP Loske, G (通讯作者)，Kathol Marienkrankenhaus GmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
EM loske.chir@marienkrankenhaus.org
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NR 35
TC 64
Z9 71
U1 0
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD DEC
PY 2014
VL 85
IS 12
BP 1081
EP 1093
DI 10.1007/s00104-014-2764-4
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AW3ES
UT WOS:000346169400006
PM 24920346
DA 2026-07-24
ER
PT J
AU Leiboff, AR
AF Leiboff, A. R.
TI Vertically drained closed incision NPWT. A novel method for managing
   surgical incisions: a case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE vertically drained closed incision negative pressure wound therapy;
   incisional NPWT; vacuum-assisted closure; wound dressing; surgical wound
   infection; suction drain
ID PRESSURE WOUND THERAPY; SITE INFECTIONS; MANAGEMENT; SURGERY;
   PREVENTION; MECHANISMS
AB Topical negative pressure wound therapy (NPWT) is being used with increasing frequency to treat closed surgical incisions that are at high risk for wound complications. Known benefits of topical NPWT include improved perfusion, physical wound support and isolation. This case series report of four colon operations introduces a method to manage closed surgical incisions that is designed to potentiate the effects of topical NPWT. Channel drains are placed vertically through a closed incision and in contact with the foam sponge of a NPWT dressing. The drains transmit negative pressure into the wound in order to enhance fluid removal, reduce dead space and improve tissue apposition for primary healing.
C1 Stony Brook Med, Hlth Sci Ctr, Dept Surg, Div Colon & Rectal Surg, Stony Brook, NY 11794 USA.
C3 State University of New York (SUNY) System; Stony Brook University;
   Stony Brook University Hospital
RP Leiboff, AR (通讯作者)，Stony Brook Med, Hlth Sci Ctr, Dept Surg, Div Colon & Rectal Surg, T18-046B, Stony Brook, NY 11794 USA.
EM Arnold.Leiboff@stonybrookmedicine.edu
CR Adogwa O., 2014, SPINE J, DOI 10.10161j.spinee.2014.04.0I I
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   Kubek E.VV., 2013, MICROBIAL PATHOGENS
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   TADYCH K, 1987, SURG GYNECOL OBSTET, V165, P483
   Tauber R, 2013, J PLAST RECONSTR AES, V66, P390, DOI 10.1016/j.bjps.2012.09.030
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NR 23
TC 4
Z9 5
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2014
VL 23
IS 12
BP 623
EP +
DI 10.12968/jowc.2014.23.12.623
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AW4EA
UT WOS:000346232800004
PM 25492278
DA 2026-07-24
ER
PT J
AU Kostaras, EK
   Tansarli, GS
   Falagas, ME
AF Kostaras, Efthymios K.
   Tansarli, Giannoula S.
   Falagas, Matthew E.
TI Use of Negative-Pressure Wound Therapy in Breast Tissues: Evaluation of
   the Literature
SO SURGICAL INFECTIONS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; PYODERMA-GANGRENOSUM; RECONSTRUCTION;
   MANAGEMENT; SALVAGE; MULTICENTER; ULCERS; FLAP
AB Background: Negative-pressure wound therapy (NPWT) has been suggetsed to have a positive impact on the healing of sternal or extremity wounds. However, few data deriving from breast surgery have been published. We evaluated the available literature regarding the effectiveness of NPWT systems in the healing of breast tissues.
   Methods: The PubMed and Scopus databases were searched systematically, and all studies that provided relevant data were considered eligible for inclusion in the review. Twenty studies (154 female patients) met the inclusion criteria (four cohort studies, one case series, and 15 case reports).
   Results: The NPWT system was used alone in 17 patients and in combination with other techniques in the remaining 137. The lesion was secondary to plastic surgery in 107 women, other operations in 40 women (38 of them for breast cancer), and primary breast infection in seven women. Infections (including necrotizing fasciitis), pyoderma gangrenosum, and necrosis were among the most common complications for which NPWT was used. In total, 150 of 154 patients receiving NPWT healed completely. Two patients died before complete closure for reasons unrelated to the wound, and NPWT failed in two patients who healed later with muscle flap coverage.
   Conclusion: The scant published evidence suggests that NPWT systems might be useful in the healing of complicated breast wounds. However, larger studies are needed to investigate the effectiveness of this system further before it is established in breast surgery.
C1 [Kostaras, Efthymios K.; Tansarli, Giannoula S.; Falagas, Matthew E.] Alfa Inst Biomed Sci, Athens 15123, Greece.
   [Falagas, Matthew E.] IASO Gen Hosp, IASO Grp, Dept Internal Med Infect Dis, Athens, Greece.
   [Falagas, Matthew E.] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA.
C3 Alfa Institute Of Biomedical Sciences; Tufts University
RP Falagas, ME (通讯作者)，Alfa Inst Biomed Sci, 9 Neapoleos St, Athens 15123, Greece.
EM m.falagas@aibs.gr
CR Angarita FA, 2014, BREAST CANCER-TOKYO, V21, P108, DOI 10.1007/s12282-010-0219-4
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   Stoeckel WT, 2006, BREAST, V15, P610, DOI 10.1016/j.breast.2005.11.006
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NR 33
TC 18
Z9 20
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD DEC 1
PY 2014
VL 15
IS 6
BP 679
EP 685
DI 10.1089/sur.2013.165
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA AW5TA
UT WOS:000346335500003
PM 24871230
DA 2026-07-24
ER
PT J
AU Shih, YJ
   Chang, SC
   Wang, CH
   Dai, NT
   Chen, SG
   Chen, TM
   Tzeng, YS
AF Shih, Yu-Jen
   Chang, Shun-Cheng
   Wang, Chih-Hsin
   Dai, Niann-Tzyy
   Chen, Shyi-Gen
   Chen, Tim-Mo
   Tzeng, Yuan-Sheng
TI A Simple Protocol for the Management of Deep Sternal Surgical Site
   Infection: A Retrospective Study of Twenty-Five Cases
SO SURGICAL INFECTIONS
LA English
DT Article
ID OPEN-HEART-SURGERY; MEDIASTINITIS; FLAP
AB Background: Deep sternal incisional surgical site infection is a serious and potentially life-threatening complication after open heart surgery. Although a rare post-operative complication, the rates of post-operative morbidity and mortality are greater in patients who develop a deep sternal incisional surgical site infection than in those who do not.
   Methods: We evaluated retrospectively the results of patients who developed a deep sternal incisional surgical site infection who were treated with either a pectoralis major flap or delayed primary closure after previous negative-pressure wound therapy (NWPT). From July 2007 to July 2012, 25 patients had a deep sternal incisional surgical site infection after open heart surgery in the Departments of Plastic Surgery and Cardiac Surgery of the Tri-Service General Hospital Medical Center. Sternal refixation was not performed in our patients.
   Results: In 15 patients, a unilateral or bilateral pectoralis major advancement flap with a myocutaneous or muscle flap was used. In seven patients, delayed primary closure was performed after NPWT. One patient received a rectus abdominis myocutaneous flap and another received a free anterior lateral thigh flap. One patient died after developing nosocomial pneumonia with severe sepsis after debridement.
   Conclusions: In our series, no patient required sternal re-fixation. Our findings suggest that delayed primary closure and use of a unilateral or bilateral pectoralis major flap following NPWT for a deep sternal incisional surgical site infection are simple and quick methods for managing such difficult surgical incisions even if the deep sternal surgical site infection is located in the lower one-third of the sternum.
C1 [Shih, Yu-Jen; Chang, Shun-Cheng; Wang, Chih-Hsin; Dai, Niann-Tzyy; Chen, Shyi-Gen; Chen, Tim-Mo; Tzeng, Yuan-Sheng] Natl Def Med Ctr, Triserv Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, Taipei 114, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical University
RP Tzeng, YS (通讯作者)，Natl Def Med Ctr, Triserv Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, 325 Cheng Kung Rd Sec 2, Taipei 114, Taiwan.
EM m6246kimo@yahoo.com.tw
RI Tzeng, Yuan-sheng/AAD-8843-2020; Shih, Yu-Jen/JAC-4777-2023; Chen,
   Tim/KVV-8381-2024
CR [Anonymous], J MED SCI
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NR 20
TC 3
Z9 3
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD DEC 1
PY 2014
VL 15
IS 6
BP 815
EP 820
DI 10.1089/sur.2013.245
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA AW5TA
UT WOS:000346335500024
PM 25493910
DA 2026-07-24
ER
PT J
AU Wu, CC
   Chew, KY
   Chen, CC
   Kuo, YR
AF Wu, Cheng-Chun
   Chew, Khong-Yik
   Chen, Chien-Chang
   Kuo, Yur-Ren
TI Antimicrobial-Impregnated Dressing Combined with Negative-Pressure Wound
   Therapy Increases Split-Thickness Skin Graft Engraftment: A Simple
   Effective Technique
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE antimicrobial-impregnated dressing; negative-pressure wound therapy;
   skin graft
ID VACUUM-ASSISTED CLOSURE; POLYHEXAMETHYLENE BIGUANIDE; CLINICAL-TRIAL;
   RECONSTRUCTION; BOLSTER
AB OBJECTIVE: Immobilization and adequate surface contact to wounds are critical for skin graft take. Techniques such as the tie-over dressing, cotton bolster, and vacuum-assisted closure are used to address this, but each has its limitations. This study is designed to assess the effect of antimicrobial-impregnated dressing (AMD) combined with negative-pressure wound therapy (NPWT) on skin graft survival.
   DESIGN: Retrospective case-control study
   PARTICIPANTS: Patients with chronic or contaminated wounds treated with split-thickness skin graft. A broad spectrum of wounds was included, from causes such as trauma, burns, chronic diabetic ulcers, and infection.
   INTERVENTIONS: Antimicrobial-impregnated dressing, which contains 0.2% polyhexamethylene biguanide, with NPWT
   MAIN OUTCOME MEASURE: Success of skin graft MAIN RESULTS: In the AMD group, all skin grafts achieved 100% take without secondary intervention. No infection or graft failure was observed in any patients, and no complications, such as hematoma or seroma formation, were noted, although in the control group partial loss of skin grafts was noted in 3 patients. Infection and inadequate immobilization were thought to be the main reasons. There were no hematoma or seroma formations in the control group.
   CONCLUSION: Use of an AMD dressing with NPWT after split-thickness skin grafting can be an effective method to ensure good graft to wound contact and enhances skin graft take in chronic and contaminated wounds.
C1 [Wu, Cheng-Chun; Chew, Khong-Yik; Chen, Chien-Chang; Kuo, Yur-Ren] Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Div Plast & Reconstruct Surg,Dept Surg, Taoyuan, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital
RP Wu, CC (通讯作者)，Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Div Plast & Reconstruct Surg,Dept Surg, Taoyuan, Taiwan.
OI Kuo, Yur-Ren/0000-0002-9388-5009
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NR 23
TC 22
Z9 25
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2015
VL 28
IS 1
BP 21
EP 27
DI 10.1097/01.ASW.0000459038.81701.fb
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA AW6XR
UT WOS:000346409500007
PM 25502972
DA 2026-07-24
ER
PT J
AU Mosser, P
   Kelm, J
   Anagnostakos, K
AF Mosser, Philipp
   Kelm, Jens
   Anagnostakos, Konstantinos
TI Negative Pressure Wound Therapy in the Management of Late Deep
   Infections After Open Reconstruction of Achilles Tendon Rupture
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE Achilles tendon; infection; split-thickness skin graft; vacuum-assisted
   closure
ID VACUUM-ASSISTED CLOSURE; COVERAGE; REPAIR; COMPLICATIONS; METAANALYSIS;
   STATE
AB Infection is a major complication after open reconstruction of Achilles tendon ruptures. We report on the use of vacuum-assisted closure (VAC) therapy in the treatment of late deep infections after open Achilles tendon reconstruction. Six patients (5 males [83.33%], 1 female [16.67%]; mean age, 52.8 [range 37 to 66] years) were been treated using an identical protocol. Surgical management consisted of debridement, lavage, and necrectomy of infected tendon parts. The VAC therapy was used for local wound preconditioning and infection management. A continuous negative pressure of 125 mm Hg was applied on each wound. For final wound closure, a split-thickness skin graft was performed. The skin graft healing process was also supported by VAC therapy during the first 5 days. The VAC dressings were changed a mean average of 3 (range 1 to 4) times until split-thickness skin grafting could be performed. The mean total duration of the VAC therapy was 13.6 +/- 5.9 days. The mean hospital stay was 31.2 +/- 15.9 days. No complications with regard to bleeding, seroma, or hematoma formation beneath the skin graft were observed. At a mean follow-up duration of 29.9 (range 4 to 65) months, no re-infection or infection persistence was observed. The VAC device seems to be a valuable tool in the treatment of infected tendons. The generalization of these conclusions should await the results of future studies with larger patient series. (C) 2015 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Mosser, Philipp; Anagnostakos, Konstantinos] Univ Klinikum Saarlandes, Klin Orthopadie & Orthopad Chirurg, D-66421 Homburg, Germany.
   [Kelm, Jens] Chirurg Orthopad Zentrum Illingen, Illingen, Germany.
C3 Universitatsklinikum des Saarlandes
RP Anagnostakos, K (通讯作者)，Univ Klinikum Saarlandes, Klin Orthopadie & Orthopad Chirurg, D-66421 Homburg, Germany.
EM k.anagnostakos@web.de
RI Anagnostakos, Konstantinos/MGC-8753-2025
CR Anagnostakos K, 2012, J WOUND CARE, V21, P333, DOI 10.12968/jowc.2012.21.7.333
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NR 22
TC 14
Z9 17
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JAN-FEB
PY 2015
VL 54
IS 1
BP 2
EP 6
DI 10.1053/j.jfas.2014.09.040
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA AW7CH
UT WOS:000346421600002
PM 25451209
DA 2026-07-24
ER
PT J
AU Glass, GE
   Jain, A
AF Glass, G. E.
   Jain, A.
TI Pretibial lacerations: Experience from a lower limb trauma centre and
   systematic review
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Pretibial laceration; Haematoma; Management; Dunkin classification;
   Elderly
ID SKIN-GRAFTS; MANAGEMENT; INJURY; MOBILIZATION; HEMATOMAS; THICKNESS;
   CLOSURE; WOUNDS
AB Background: Pretibial lacerations are an important and neglected problem among the elderly. Poor management leads to prolonged hospitalisation and terminal decline. This study summarises our experience and evidence from the literature to ascertain an evidence-based rationale for referral and management.
   Methods: Our data were obtained from review of a prospectively gathered database. Additionally, Pubmed, Embase, Medline, and the Cochrane Database of Systematic Reviews were searched through July 2013, with eligible studies evaluated using standard methodology.
   Results: Seventy-three pretibial lacerations in 73 patients (63 females) were identified. Mean age was 78 +/- 14, 1SD. Sixty patients were managed operatively with a mean length of stay of 11 +/- 7 days, 1SD when uncomplicated by medical co-morbidity. Seven deaths occurred (4 in-hospital; 2 treated surgically and 2 treated conservatively) and 3 deaths occurred within 3 months of discharge; a death rate more than twice that of matched controls. Donor site "over-grafting" was performed in 19 cases and resulted in accelerated donor site healing (11 +/- 9 days, 1SD vs. 29 +/- 42 days, 1SD; P < 0.001). Negative pressure wound therapy delayed discharge (21 +/- 23 days, 1SD vs. 15 +/- 14 days, 1SD; P = 0.028). Microbiological sampling is unhelpful. Bed rest is unnecessary. "De-fatting" the flap is unproven.
   Conclusion: Admissions expose the elderly to physical/functional decline and death. Our findings support a change of practice, minimising admissions for minor (Dunkin type I/II) injuries and rapid, protocol-driven surgical intervention and discharge for Dunkin type III/IV injuries with avoidance of negative pressure wound therapy in all but selected cases. (C) 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Glass, G. E.; Jain, A.] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford OX3 7FY, England.
   [Jain, A.] Imperial Coll NHS Fountat Trust, Charing Cross Hosp, Dept Plast & Reconstruct Surg, London W6 8RF, England.
C3 University of Oxford; Kennedy Institute for Rheumatology; Imperial
   College London
RP Jain, A (通讯作者)，Imperial Coll NHS Fountat Trust, Charing Cross Hosp, Dept Plast Surg, Fulham Palace Rd, London W6 8RF, England.
EM ajainuk@aol.com
RI Glass, Graeme/I-7011-2019
FU Academy of Medical Sciences; Academy of Medical Sciences (AMS)
   [AMS-SGCL6-Glass] Funding Source: researchfish
FX GG is in receipt of a grant from the Academy of Medical Sciences for
   work unrelated to this study.
CR [Anonymous], NURS STAND
   [Anonymous], NURS STAND
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NR 41
TC 17
Z9 22
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2014
VL 67
IS 12
BP 1694
EP 1702
DI 10.1016/j.bjps.2014.08.001
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AW8ZB
UT WOS:000346546600013
PM 25175272
DA 2026-07-24
ER
PT J
AU Loaec, E
   Vaillant, PY
   Bonne, L
   Marianowski, R
AF Loaec, E.
   Vaillant, P. -Y.
   Bonne, L.
   Marianowski, R.
TI Negative-pressure wound therapy for the treatment of pharyngocutaneous
   fistula
SO EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
LA English
DT Article
DE Negative-pressure wound therapy; Pharyngocutaneous fistula; Head and
   neck cancer; Total laryngectomy; Partial laryngectomy
ID VACUUM-ASSISTED CLOSURE; NECK WOUNDS; MANAGEMENT; HEAD; LARYNGECTOMY;
   EXPERIENCE; SURGERY; SYSTEM
AB Introduction: Pharyngocutaneous fistula is a well-known complication of head and neck cancer surgery. The purpose of this study was to determine the value of negative-pressure wound therapy (NPWT) for the treatment of these fistulas. NPWT is used in many fields of medicine, but its use in otorhinolaryngology has been rarely reported. NPWT is a cost-effective means to accelerate wound healing.
   Patients and methods: A single-centre retrospective study was conducted on 7 patients with pharyngocutaneous fistula following surgery for squamous cell carcinoma between January 2011 and April 2013. These fistulas were treated by negative-pressure wound therapy (NPWT).
   Results: This series comprised seven male patients with a mean age of 65 years and 9 months. The mean duration of treatment was 23 days (range: 11 to 42 days). Two patients had a history of radiotherapy for pharyngolaryngeal cancer. Negative-pressure wound therapy achieved cure of the fistula in all patients with satisfactory acceptability. Mean follow-up was 10 months (range: 6 months to 2 years).
   Conclusion: Negative-pressure wound therapy represents a valuable treatment option in certain settings for the management of pharyngocutaneous fistula following head and neck cancer surgery. (C) 2014 Published by Elsevier Masson SAS.
C1 [Loaec, E.; Vaillant, P. -Y.; Bonne, L.] Hop Instruct Armees Clermont Tonnerre, Serv ORL CCF, F-29241 Brest, France.
   [Marianowski, R.] CHRU Brest, Hop Morvan, Serv ORL CCF, F-29609 Brest, France.
C3 Universite de Bretagne Occidentale; CHU Brest
RP Loaec, E (通讯作者)，Hop Instruct Armees Clermont Tonnerre, Serv ORL CCF, Rue Colonel Fontferrier,CC 41, F-29241 Brest, France.
EM emilye.loaec@gmail.com
OI remi, marianowski/0000-0001-8545-9045
CR Andrews BT, 2008, ANN OTO RHINOL LARYN, V117, P298, DOI 10.1177/000348940811700410
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   Gallo O, 2012, LARYNGOSCOPE, V122, P785, DOI 10.1002/lary.22403
   Le Franc B, 2010, ANN CHIR PLAST ESTH, V55, P195, DOI 10.1016/j.anplas.2009.04.001
   Mclean JN, 2012, ANN PLAS SURG, V68, P442, DOI 10.1097/SAP.0b013e318225832a
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
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NR 24
TC 27
Z9 36
U1 0
U2 4
PU ELSEVIER MASSON
PI MILANO
PA VIA PALEOCAPA 7, 20121 MILANO, ITALY
SN 1879-7296
EI 1879-730X
J9 EUR ANN OTORHINOLARY
JI Eur. Ann. Otorhinolaryngol.-Head Neck Dis.
PD DEC
PY 2014
VL 131
IS 6
BP 351
EP 355
DI 10.1016/j.anorl.2013.12.001
PG 5
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA AW9SU
UT WOS:000346598400006
PM 25439627
DA 2026-07-24
ER
PT J
AU Suzuki, T
   Minehara, A
   Matsuura, T
   Kawamura, T
   Soma, K
AF Suzuki, Takashi
   Minehara, Akihiro
   Matsuura, Terumasa
   Kawamura, Tadashi
   Soma, Kazui
TI Negative-pressure wound therapy over surgically closed wounds in open
   fractures
SO JOURNAL OF ORTHOPAEDIC SURGERY
LA English
DT Article
DE fractures, open; negative-pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; DEGLOVING INJURIES; SKIN; MANAGEMENT;
   INCISIONS; DEVICE; FLAPS; LIMB
AB Purpose. To evaluate the outcome of open fracture surgery with negative-pressure wound therapy (NPWT) applied directly over surgical wounds.
   Methods. Medical records of 10 men and 4 women aged 6 to 70 (mean, 43.7) years who underwent internal fixation, external fixation, or splint application for open fractures of the lower leg (n=7), foot and ankle (n=5), or knee (n=2), and NPWT were reviewed. The NPWT was applied directly over the surgical wound without a non-adherent contact layer. The foam was changed every 3 days. The standard negative pressure was 125 mm Hg. The NPWT was stopped when the wound discharge became <50 ml per day. The duration of NPWT and the level of negative pressure were recorded, as were wound condition, reasons for NPWT, and outcome.
   Results. The mean duration of NPWT was 9.1 (range, 3-24) days. Four patients developed maceration of the skin under the foam, whereas 2 patients developed skin blisters under the drape. No necrosis of flap skin or infection occurred, and all the fractures eventually united.
   Conclusions. Maceration of the skin was seen in some cases but did not affect the overall outcome. NPWT directly over the skin surface had no deleterious effect on wound and fracture healing.
C1 [Suzuki, Takashi; Minehara, Akihiro; Matsuura, Terumasa; Kawamura, Tadashi; Soma, Kazui] Kitasato Univ Hosp, Ctr Emergency Med, Sagamihara, Kanagawa 2520375, Japan.
C3 Kitasato University
RP Suzuki, T (通讯作者)，Kitasato Univ Hosp, Ctr Emergency Med, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520375, Japan.
EM takashisuzuki911@yahoo.co.jp
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
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NR 26
TC 31
Z9 33
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2309-4990
J9 J ORTHOP SURG-HONG K
JI J. Orthop. Surg.
PY 2014
VL 22
IS 1
BP 30
EP 34
DI 10.1177/230949901402200109
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA AX0GF
UT WOS:000346630400009
PM 24781609
OA gold
DA 2026-07-24
ER
PT J
AU Mirzabeigi, MN
   Wilson, AJ
   Fischer, JP
   Basta, M
   Kanchwala, S
   Kovach, SJ
   Serletti, JM
   Wu, LC
AF Mirzabeigi, Michael N.
   Wilson, Anthony J.
   Fischer, John P.
   Basta, Marten
   Kanchwala, Suhail
   Kovach, Stephen J.
   Serletti, Joseph M.
   Wu, Liza C.
TI Predicting and Managing Donor-Site Wound Complications in Abdominally
   Based Free Flap Breast Reconstruction: Improved Outcomes with Early
   Reoperative Closure
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT Aesthetic Meeting
CY APR 24-29, 2014
CL San Francisco, CA
ID FREE TISSUE TRANSFER; SPARING FREE TRAM; DIEP FLAP; FUNCTIONAL IMPACT;
   MYOCUTANEOUS FLAP; MORBIDLY OBESE; SIEA FLAPS; WALL; ABDOMINOPLASTY;
   EXPERIENCE
AB Background: The purpose of this study was to (1) determine risk factors predictive of delayed abdominal healing; (2) determine characteristics that perpetuate progression to chronic abdominal wounds and describe the resultant morbidity; and (3) identify outcomes and cost following two treatment strategies-conservative wound care and early reoperative primary closure.
   Methods: Patients were identified from a database of abdominally based free flaps performed from January of 2005 through July of 2012.
   Results: One thousand two hundred eighteen abdominal donor sites were reviewed, and 167 cases (13.7 percent) of delayed abdominal wound healing were identified. Obesity (p < 0.0001), smoking (p = 0.043), bilateral reconstruction (p = 0.006), preoperative chemotherapy (p = 0.006), and abdominal mesh (p = 0.028) were independently associated with delayed healing. Initiation of chemotherapy p < 0.0001), wet-to-dry wound care (p = 0.001), negative-pressure wound therapy (p = 0.002), and flap type (p = 0.047) were predictive of chronic wounds, and such wounds generated higher rates of hospital readmission (p = 0.009), mesh complications (p < 0.001), and hernia/bulge (p = 0.006). Patients who underwent delayed primary wound closure were more likely to have a well-healed abdomen within 1 month (90.9 percent versus 24.2 percent; p < 0.0001), resulting in lower cost, fewer hospital readmissions, lower rates of scar revision, and lower rates of mesh complications/hernia/bulge.
   Conclusions: Chronic abdominal wounds were associated with abdominal wall sequelae, including hernia. Early reoperative primary wound closure has been successfully and selectively implemented, resulting in improved patient outcomes.
C1 [Mirzabeigi, Michael N.; Wilson, Anthony J.; Fischer, John P.; Basta, Marten; Kanchwala, Suhail; Kovach, Stephen J.; Serletti, Joseph M.; Wu, Liza C.] Univ Penn Hlth Syst, Div Plast Surg, Philadelphia, PA USA.
C3 University of Pennsylvania
RP Wu, LC (通讯作者)，Div Plast Surg, 10 Penn Tower 3400 Spruce St, Philadelphia, PA 19104 USA.
EM liza.wu@uphs.upenn.edu
RI Basta, Marten/I-8953-2019
OI Basta, Marten/0000-0002-9937-5886
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   Selber JC, 2010, PLAST RECONSTR SURG, V126, P1142, DOI 10.1097/PRS.0b013e3181f02520
   Selber JC, 2009, PLAST RECONSTR SURG, V124, P1015, DOI 10.1097/PRS.0b013e3181b453fd
   Spear SL, 2007, PLAST RECONSTR SURG, V119, P788, DOI 10.1097/01.prs.0000252003.14537.d2
   Suominen S, 1997, ANN PLAS SURG, V39, P229, DOI 10.1097/00000637-199709000-00002
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   Vega S, 2008, PLAST RECONSTR SURG, V122, P329, DOI 10.1097/PRS.0b013e31817f45cb
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   Wu LC, 2008, PLAST RECONSTR SURG, V122, P702, DOI 10.1097/PRS.0b013e3181823c15
NR 36
TC 26
Z9 29
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2015
VL 135
IS 1
BP 14
EP 23
DI 10.1097/PRS.0000000000000805
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA AX4OG
UT WOS:000346911000044
PM 25539292
DA 2026-07-24
ER
PT J
AU Coutin, JV
   Lanz, OI
   Magnin-Bissel, GC
   Ehrich, MF
   Miller, EI
   Werre, SR
   Riegel, TO
AF Coutin, Julia V.
   Lanz, Otto I.
   Magnin-Bissel, Geraldine C.
   Ehrich, Marion F.
   Miller, Emily I.
   Werre, Stephen R.
   Riegel, Thomas O.
TI Cefazolin Concentration in Surgically Created Wounds Treated With
   Negative Pressure Wound Therapy Compared to Surgically Created Wounds
   Treated With Nonadherent Wound Dressings
SO VETERINARY SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TANDEM MASS-SPECTROMETRY; MICROVASCULAR
   BLOOD-FLOW; BETA-LACTAM ANTIBIOTICS; ENDOTHELIAL GROWTH-FACTOR;
   SOLID-PHASE EXTRACTION; ANTIBACTERIAL ACTIVITY; LIQUID-CHROMATOGRAPHY;
   PROTEIN-BINDING; CYTOKINE LEVELS
AB ObjectiveTo compare cefazolin concentrations in biopsied tissue samples collected from surgically created wounds treated with negative pressure wound therapy to those collected from surgically created wounds treated with nonadherent dressings.
   Study DesignProspective, controlled, experimental study.
   AnimalsAdult female spayed Beagles (n=12).
   MethodsFull thickness cutaneous wounds were created on each antebrachium (n=24). Immediately after surgery, cefazolin (22mg/kg intravenously [IV]) was administered to each dog and continued every 8hours during the study. The right wound was randomly assigned to group I or group II whereas the wound on the contralateral antebrachium was assigned to the other group. Group I wounds were treated with negative pressure wound therapy (NPWT) and group II wounds were treated with nonadherent dressings for 3 days. Dressings were changed and tissue biopsies obtained from wound beds at 24hours intervals for both groups. Cefazolin wound tissue and plasma concentrations were measured by liquid chromatography mass spectrometry (LC-MS/MS). Blood samples for measuring plasma cefazolin concentrations were collected before biopsy sampling. At the time of surgery and at each subsequent bandage change, wound beds were swabbed and submitted for aerobic and anaerobic culture.
   ResultsAfter initiating cefazolin treatment, wound tissue antibiotic concentrations between treatment groups were not significantly different at any sampling time. Similarly, after initiating cefazolin treatment, plasma cefazolin concentrations were not significantly different at any sampling time for individual dogs.
   ConclusionsUsing a canine experimental model, NPWT treatment of surgically created wounds does not statistically impact cefazolin tissue concentrations when compared with conventional nonadherent bandage therapy.
C1 [Coutin, Julia V.; Lanz, Otto I.; Miller, Emily I.; Riegel, Thomas O.] Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Phase 2 Duckpond Dr, Blacksburg, VA 24061 USA.
   [Magnin-Bissel, Geraldine C.] Virginia Maryland Reg Coll Vet Med, Dept Res & Grad Studies, Blacksburg, VA 24061 USA.
   [Ehrich, Marion F.; Werre, Stephen R.] Virginia Maryland Reg Coll Vet Med, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA.
RP Lanz, OI (通讯作者)，Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Phase 2 Duckpond Dr, Blacksburg, VA 24061 USA.
EM olanz@vt.edu
OI Ehrich, Marion/0000-0002-5466-4203; Magnin,
   Geraldine/0000-0001-9061-7263
FU Virginia-Maryland Regional College of Veterinary Medicine, Veterinary
   Memorial Fund
FX Funded in part by the Virginia-Maryland Regional College of Veterinary
   Medicine, Veterinary Memorial Fund.
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NR 51
TC 13
Z9 19
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD JAN
PY 2015
VL 44
IS 1
BP 9
EP 16
DI 10.1111/j.1532-950X.2014.12218.x
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA AX5JU
UT WOS:000346963000003
PM 24962470
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ishikawa, K
   Minamimoto, T
   Mizuki, T
   Furukawa, H
AF Ishikawa, Kosuke
   Minamimoto, Toshiyuki
   Mizuki, Takeo
   Furukawa, Hiroshi
TI Surgical Management of Extensive Peristomal Pyoderma Gangrenosum
   Associated With Colon Cancer
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE colonic neoplasms; negative-pressure wound; ostomy; pyoderma gangrenosum
   skin transplantation; surgical stomas; therapy
ID VACUUM-ASSISTED CLOSURE; CLINICAL-FEATURES; THERAPY
AB BACKGROUND: Extensive peristomal skin ulcer due to pyoderma gangrenosum is difficult to manage and causes significant morbidity.
   CASE: A 69-year-old man presented with a 10x7-cm painful peristomal skin necrosis during cancer chemotherapy for metastatic colon adenocarcinoma. The diagnosis of peristomal pyoderma gangrenosum was made on the basis of the presence of the skin necrosis with a well-defined, undermined, violaceous border. One month after the presentation along with daily cleansing and minimal debridement without immunosuppressive treatments, wound bed preparation was deemed sufficient for a split-thickness skin graft using negative pressure wound therapy for graft fixation. One month after the operation, the ulcer was completely healed and the patient could manage ostomy pouching independently. He died of cancer 5 months later; no recurrence of the ulcer was observed during this period.
   CONCLUSION: Peristomal pyoderma gangrenosum was successfully treated with skin grafting after local wound management. Negative pressure wound therapy was useful for skin graft fixation in the peristomal region.
C1 [Ishikawa, Kosuke; Minamimoto, Toshiyuki] Hakodate Municipal Hosp, Dept Plast & Reconstruct Surg, Hakodate, Hokkaido 0418680, Japan.
   [Mizuki, Takeo] Hakodate Municipal Hosp, Dept Nursing Care, Hakodate, Hokkaido 0418680, Japan.
   [Furukawa, Hiroshi] Hokkaido Univ Grad Sch Med, Dept Plast & Reconstruct Surg, Hakodate, Hokkaido, Japan.
C3 Hokkaido University
RP Ishikawa, K (通讯作者)，Hakodate Municipal Hosp, Dept Plast & Reconstruct Surg, Minato Chou 1-10-1, Hakodate, Hokkaido 0418680, Japan.
EM kishikawa-hok@umin.org
RI Ishikawa, Kosuke/R-4781-2019
OI Ishikawa, Kosuke/0000-0002-6068-7276
CR Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
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NR 16
TC 12
Z9 13
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JAN-FEB
PY 2015
VL 42
IS 1
BP 102
EP 105
DI 10.1097/WON.0000000000000098
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AY3BZ
UT WOS:000347460800016
PM 25549316
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Son, BS
   Lee, S
   Cho, WH
   Hwang, JJ
   Kim, KD
   Kim, DH
AF Son, Bong Soo
   Lee, Sungsoo
   Cho, Woo Hyun
   Hwang, Jung Joo
   Kim, Kil Dong
   Kim, Do Hyung
TI Modified blowhole skin incision using negative pressure wound therapy in
   the treatment of ventilator-related severe subcutaneous emphysema
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Subcutaneous emphysema; Mechanical ventilation; Negative pressure wound
   therapy
ID HOLES
AB OBJECTIVES: A 2-3-cm blowhole incision in the supraclavicular or infraclavicular area is widely used to eliminate the presence of subcutaneous air in cases of life-threatening subcutaneous emphysema (SE). However, when the patient is supported by mechanical ventilation, it is difficult to eliminate completely such air because mechanical ventilation leads consistently to the formation of large amounts of air. To overcome this, we applied negative pressure wound therapy (NPWT) along with blowhole incisions for the treatment of severe SE.
   METHODS: To evaluate the feasibility of NPWT, we retrospectively analysed the clinical outcomes of 10 patients who developed severe SE during ventilator care and were treated with a modified blowhole incision using NPWT from January 2009 to November 2013.
   RESULTS: All patients showed immediate improvement in SE after NPWT, and no symptom aggravation occurred after NPWT. The mean duration of NPWT was 7.5 +/- 5.1 (range, 3-14) days, and the mean number of dressing changes was 1.5 +/- 0.7 (range, 1-2). There were no blowhole-incision-related wound infections or any other complications.
   CONCLUSIONS: While it is not necessary to apply a blowhole incision with NPWT in all cases of SE, this therapy can be helpful for patients with severe SE associated with mechanical ventilation requiring rapid decompression.
C1 [Son, Bong Soo; Kim, Do Hyung] Pusan Natl Univ, Yangsan Hosp, Dept Thorac & Cardiovasc Surg, Yangsan 626770, Gyeongsangnam D, South Korea.
   [Lee, Sungsoo] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Thorac & Cardiovasc Surg, Seoul, South Korea.
   [Cho, Woo Hyun] Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Yangsan 626770, Gyeongsangnam D, South Korea.
   [Hwang, Jung Joo; Kim, Kil Dong] Eulji Univ Hosp, Dept Thorac & Cardiovasc Surg, Taejon, South Korea.
C3 Pusan National University; Pusan National University Hospital; Yonsei
   University; Severance Hospital; Yonsei University Health System; Pusan
   National University; Pusan National University Hospital; Eulji
   University; Eulji University Hospital
RP Kim, DH (通讯作者)，Pusan Natl Univ, Yangsan Hosp, Dept Thorac & Cardiovasc Surg, Yangsan 626770, Gyeongsangnam D, South Korea.
EM yumccs@nate.com
OI Son, Bong Soo/0000-0001-6681-6094; Lee, Sungsoo/0000-0001-8998-9510
FU Research Institute for Convergence of Biomedical Science and Technology,
   Pusan National University Yangsan Hospital
FX This work was supported by the Research Institute for Convergence of
   Biomedical Science and Technology, Pusan National University Yangsan
   Hospital.
CR Byun Chun Sung, 2013, Korean J Thorac Cardiovasc Surg, V46, P383, DOI 10.5090/kjtcs.2013.46.5.383
   Dumont SW, 2008, ANAESTHESIA, V63, P212, DOI 10.1111/j.1365-2044.2007.05426.x
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   Turnbull DK, 2002, ACTA ANAESTH SCAND, V46, P227
   Vijayalakshmi A M, 2003, Indian Pediatr, V40, P1092
NR 8
TC 18
Z9 22
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD DEC
PY 2014
VL 19
IS 6
BP 904
EP 907
DI 10.1093/icvts/ivu287
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AY5OR
UT WOS:000347622300004
PM 25164135
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Cheng, HT
   Hsu, YC
   Wu, CI
AF Cheng, Hsu-Tang
   Hsu, Yung-Chang
   Wu, Chao-I
TI Efficacy and safety of negative pressure wound therapy for Szilagyi
   grade III peripheral vascular graft infection
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Review; Negative pressure wound therapy; Vascular surgical procedures;
   Surgical wound
ID VACUUM-ASSISTED CLOSURE; GROIN
AB A best evidence topic in vascular surgery was written according to a structured protocol. The question addressed was whether it is safe and effective to use negative pressure wound therapy (NPWT) for Szilagyi grade III (i.e. the arterial implant proper involved in the infection) peripheral vascular graft infection. Altogether, 69 papers were found using the reported search. From the search results, reference lists of potentially eligible studies and related citations in PubMed, seven papers represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. In the only randomized, controlled trial that compared NPWT (n = 10) and alginate dressing change (n = 10), the NPWT group demonstrated shorter time to full skin epithelialization (median 57 vs 104 days; P = 0.026). In the other six case series, the recruited case number ranged from 12 to 72. The mode of NPWT varied among the included studies, with the majority using a continuous negative pressure of 125 mmHg. One study combined NPWT and sartorius myoplasty, another used sartorius myoplasty in selected cases and others did not. The mean duration of using NPWT ranged from 14.2 to 43 days. The mean duration to achieve complete wound healing ranged from 24 (the study with sartorius myoplasty) to 51 days. The NPWT treatment failure rate ranged from 0 (the study with sartorius myoplasty) to 25%. The major complication of NPWT was bleeding and the incidence rate was reported to be <10%. We conclude that the amount of evidence for recommending NPWT alone as the first-line treatment for Szilagyi grade III peripheral vascular graft infection is small with only one small-sized randomized controlled trial demonstrating that NPWT alone is superior to alginate dressing change in shortening the time to complete wound healing by 2 months. Limited evidence (case series with >1 year of follow-up) showed that NPWT with a continuous negative pressure of 125 mmHg, or combined NPWT and sartorius myoplasty, may shorten the time to complete wound healing by 2 months, have a >70% success rate, and have a <10% NPWT-related complication rate.
C1 [Cheng, Hsu-Tang; Hsu, Yung-Chang; Wu, Chao-I] China Med Univ Hosp, Dept Surg, Taichung, Taiwan.
   [Cheng, Hsu-Tang; Hsu, Yung-Chang; Wu, Chao-I] China Med Univ, Sch Med, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan
RP Cheng, HT (通讯作者)，China Med Univ Hosp, Dept Surg, Taichung, Taiwan.
EM hsutangcheng@gmail.com
CR Berger P, 2012, J VASC SURG, V56, P714, DOI 10.1016/j.jvs.2012.02.007
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   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
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NR 8
TC 16
Z9 20
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD DEC
PY 2014
VL 19
IS 6
BP 1048
EP U235
DI 10.1093/icvts/ivu289
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AY5OR
UT WOS:000347622300032
PM 25185571
OA Bronze
DA 2026-07-24
ER
PT J
AU Dumville, JC
   Munson, C
   Christie, J
AF Dumville, Jo C.
   Munson, Christopher
   Christie, Janice
TI Negative pressure wound therapy for partial-thickness burns
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Negative-Pressure Wound Therapy; Wound Healing; Burns [pathology;
   therapy]; Randomized Controlled Trials as Topic; Suction
   [instrumentation; methods]; Humans
ID SUBATMOSPHERIC PRESSURE; PROGRESSION; PATIENT
AB Background
   A burn wound is a complex and evolving injury, with both local and systemic consequences. Burn treatments include a variety of dressings, as well as newer strategies, such as negative pressure wound therapy (NPWT), which, by means of a suction force that drains excess fluids from the burn, tries to promote the wound healing process and minimise progression of the burn wound.
   Objectives
   To assess the effectiveness of NPWT for people with partial-thickness burns.
   Search methods
   We searched the Cochrane Wounds Group Specialised Register (searched 04 September 2014); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2014, Issue 8).
   Selection criteria
   All randomised controlled trials (RCTs) and controlled clinical trials (CCTs) that evaluated the safety and effectiveness of NPWT for partial-thickness burns.
   Data collection and analysis Two review authors used standardised forms, and extracted the data independently. We assessed each trial for risk of bias, and resolved differences by discussion.
   Main results
   One RCT, that was an interim report, satisfied the inclusion criteria. We undertook a narrative synthesis of results, as the absence of data and poor reporting precluded us from carrying out any formal statistical analysis. The trial was at high risk of bias.
   Authors' conclusions
   There was not enough evidence available to permit any conclusions to be drawn regarding the use of NPWT for treatment of partial-thickness burn wounds.
C1 [Dumville, Jo C.; Christie, Janice] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Munson, Christopher] St Johns Hosp Howden, Dept Plast Surg, Livingston, Scotland.
C3 University of Manchester
RP Dumville, JC (通讯作者)，Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
EM jo.dumville@manchester.ac.uk
RI Dumville, Jo/O-7867-2014; Christie, Janice/O-9320-2014
OI Dumville, Jo/0000-0002-6546-3685; Christie, Janice/0000-0001-6176-6075
FU National Institute for Health Research (NIHR)
FX External sources The National Institute for Health Research (NIHR) is
   the sole funder of the Cochrane Wounds Group, UK.
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NR 34
TC 35
Z9 41
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2014
IS 12
AR CD006215
DI 10.1002/14651858.CD006215.pub4
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AY5YZ
UT WOS:000347646300020
PM 25500895
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Willms, A
   Güsgen, C
   Schaaf, S
   Bieler, D
   von Websky, M
   Schwab, R
AF Willms, A.
   Guesgen, C.
   Schaaf, S.
   Bieler, D.
   von Websky, M.
   Schwab, R.
TI Management of the open abdomen using vacuum-assisted wound closure and
   mesh-mediated fascial traction
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Open abdomen; Peritonitis; Abdominal trauma; Vacuum therapy; Abdominal
   compartment syndrome
ID TEMPORARY ABDOMINAL CLOSURE; SMALL-BOWEL FISTULAS; DAMAGE-CONTROL;
   SURGICAL COMPLICATIONS; COMPARTMENT SYNDROME; NEGATIVE-PRESSURE;
   GENERAL-SURGERY; WALL DEFECTS; TRAUMA; CLASSIFICATION
AB The open abdomen has become an accepted treatment option of critically ill patients with severe intra-abdominal conditions. Fascial closure is a particular challenge in patients with peritonitis. This study investigates whether fascial closure rates can be increased in peritonitis patients by using an algorithm that combines vacuum-assisted wound closure and mesh-mediated fascial traction. Moreover, fascial closure rates for patients with peritonitis, trauma or abdominal compartment system (ACS) are compared.
   Data were collected prospectively from all patients who underwent open abdomen management at our institution from 2006 to 2012. All patients were treated under a standardised algorithm that combines vacuum-assisted closure and mesh placement at the fascial level.
   During the study period, 53 patients (mean age 53 years) underwent open abdomen management for a mean duration of 15 days. Indications for leaving the abdomen open were peritonitis (51 %), trauma (26 %), and ACS or abdominal wall dehiscence (23 %). The fascial closure rate was 79 % in an intention-to-treat analysis and 89 % in a per-protocol analysis. Mortality was 13 %. No patient developed an enteroatmospheric fistula or abdominal wall dehiscence after closure. The mean duration of treatment was significantly longer in peritonitis patients (20 days) than in patients without peritonitis (10 days) (p = 0.03). There were no significant differences in fascial closure rates between patients with peritonitis (87 %), trauma (85 %), and ACS or abdominal wall dehiscence (100 %) (p = 0.647).
   Regardless of the underlying pathology, high fascial closure rates can be achieved using a combination of vacuum-assisted closure and mesh-mediated fascial traction.
C1 [Willms, A.; Guesgen, C.; Schaaf, S.; Schwab, R.] German Armed Forces Cent Hosp Koblenz, Dept Gen Visceral & Thorac Surg, D-56072 Koblenz, Germany.
   [Willms, A.; von Websky, M.] Univ Hosp Bonn, Dept Gen Visceral Thorac & Vasc Surg, Bonn, Germany.
   [Bieler, D.] German Armed Forces Cent Hosp Koblenz, Dept Orthopaed Trauma Surg Reconstruct Surg Hand, D-56072 Koblenz, Germany.
C3 University of Bonn
RP Willms, A (通讯作者)，German Armed Forces Cent Hosp Koblenz, Dept Gen Visceral & Thorac Surg, Ruebenacher Str 170, D-56072 Koblenz, Germany.
EM ArnulfWillms@gmx.de
RI Bieler, Dan/HZL-5995-2023; Willms, Arnulf/AFN-0812-2022; von Websky,
   Martin/AFC-6767-2022
OI Bieler, Dan/0000-0002-0708-1259; Willms, Arnulf/0000-0001-9998-6735; 
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NR 53
TC 57
Z9 66
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD JAN
PY 2015
VL 400
IS 1
BP 91
EP 99
DI 10.1007/s00423-014-1240-4
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AY6WR
UT WOS:000347704100010
PM 25128414
DA 2026-07-24
ER
PT J
AU Contreras-Ruiz, J
   Ramos-Cadena, A
   Solis-Arias, P
   Lozano-Platonoff, A
   Lopez-García, LA
   Contreras-Barrera, ME
   Saenz-Corral, C
   de-la-Cruz-Garcia, I
   Cárdenas-Mejía, A
   Lopez-Oliver, R
AF Contreras-Ruiz, Jose
   Ramos-Cadena, Angeles
   Solis-Arias, Patricia
   Lozano-Platonoff, Adriana
   Lopez-Garcia, Lirio A.
   Contreras-Barrera, Martha E.
   Saenz-Corral, Claudia
   de-la-Cruz-Garcia, Isabel
   Cardenas-Mejia, Alexander
   Lopez-Oliver, Ruben
TI Negative Pressure Wound Therapy in Preseptal Orbital Cellulitis
   Complicated With Necrotizing Fasciitis and Preseptal Abscess
SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BLOOD-FLOW; MANAGEMENT; EXPERIENCE
AB Purpose: Preseptal cellulitis (PC) may be locally complicated with abscess formation and necrotizing fasciitis. If not treated promptly and adequately, it may result in further complications. The authors report a series of patients where negative pressure wound therapy (NPWT) proved a safe and valuable adjunct therapy in avoiding complications of PC and in accelerating wound healing.
   Methods: A 4 patient case series. Four male patients (11 months to 58 years old) with unilateral complicated PC.
   Interventions: Patients were admitted with PC and treated initially with specific intravenous antibiotic therapy. These patients did not respond adequately; therefore, surgical drainage and/or debridement were performed. After surgery, persistent edema and purulent discharge was observed prompting the need for adjunct NPWT every 48 to 72 hours. NPWT is the use of vacuum through a wound filler material covered with an airtight drape connected to a pump. Complete ophthalmologic examination was performed after each 48-hour cycle. Length of hospital stay, days from surgery to discharge, days from start of NPWT to discharge, clinical improvement, and safety.
   Results: Four patients were diagnosed with PC between 2 and 5 days of evolution. Two diabetic adults developed the condition secondary to trauma, the adolescent as a result of a cosmetic piercing, and the infant associated to sinusitis. NPWT reached -125 mm.Hg, except for the infant who received -75 mm.Hg. The average number of days necessary for improvement with NPWT was 6.7 days. Only 2 patients required surgical reconstruction. Time from debridement to discharge was in average 13.5 days. No ocular complications were observed, and follow up was satisfactory with normal eyelid function and aesthetics and preserved visual acuity.
   Conclusions: NPWT proved to be safe and effective for treating locally complicated PC as an adjuvant therapy to antibiotic and surgical treatment that decreased the length of hospital stay, and the time for recovery in patients that were slow responders. No ocular complications were observed in any of these patients' follow up ranging from 1 to 4 years.
C1 [Contreras-Ruiz, Jose; Lozano-Platonoff, Adriana; de-la-Cruz-Garcia, Isabel] Dr Manuel Gea Gonzalez Gen Hosp, Interdisciplinary Wound & Ost Care Ctr, Mexico City, DF, Mexico.
   [Ramos-Cadena, Angeles] Dr Manuel Gea Gonzalez Gen Hosp, Div Ophthalmol, Mexico City, DF, Mexico.
   [Solis-Arias, Patricia; Lopez-Garcia, Lirio A.; Contreras-Barrera, Martha E.; Saenz-Corral, Claudia] Dr Manuel Gea Gonzalez Gen Hosp, Div Dermatol, Mexico City, DF, Mexico.
   [Cardenas-Mejia, Alexander] Dr Manuel Gea Gonzalez Gen Hosp, Div Plast Surg, Mexico City, DF, Mexico.
   [Lopez-Oliver, Ruben] Dr Manuel Gea Gonzalez Gen Hosp, Div Ophthalmol, Oculoplast Sect, Mexico City, DF, Mexico.
RP Lopez-Oliver, R (通讯作者)，Calzada de Tlalpan 4800,Col Secc 15, Tlalpan 14080, DF, Mexico.
EM drlopezoliver@yahoo.com.mx
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NR 22
TC 12
Z9 14
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0740-9303
EI 1537-2677
J9 OPHTHAL PLAST RECONS
JI Ophthalmic Plast. Reconstr. Surg.
PD JAN-FEB
PY 2015
VL 31
IS 1
BP 23
EP 28
DI 10.1097/IOP.0000000000000163
PG 6
WC Ophthalmology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology; Surgery
GA AY7YP
UT WOS:000347772000016
PM 24896773
DA 2026-07-24
ER
PT J
AU Yumun, G
   Erdolu, B
   Toktas, F
   Eris, C
   Ay, D
   Turk, T
   As, AK
AF Yumun, Gunduz
   Erdolu, Burak
   Toktas, Faruk
   Eris, Cuneyt
   Ay, Derih
   Turk, Tamer
   As, Ahmet Kagan
TI Deep Sternal Wound Infection after Coronary Artery Bypass Surgery:
   Management and Risk Factor Analysis for Mortality
SO HEART SURGERY FORUM
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; OPEN PACKING; MEDIASTINITIS;
   THERAPY; STERNOTOMY
AB Background: Deep sternal wound infection is a life-threatening complication after cardiac surgery. The aim of this study was to investigate the factors leading to mortality, and to explore wound management techniques on deep sternal wound infection after coronary artery bypass surgery.
   Methods: Between 2008 and 2013, 58 patients with deep sternal wound infection were analyzed. Risk factors for mortality and morbidity including age, gender, body mass index, smoking status, chronic renal failure, hypertension, diabetes, and treatment choice were investigated.
   Results: In this study, 19 patients (32.7%) were treated by primary surgical closure (PSC), and 39 patients (67.3%) were treated by delayed surgical closure following a vacuum-assisted closure system (VAC). Preoperative patient characteristics were similar between the groups. Fourteen patients (24.1%) died in the postoperative first month. The mortality rate and mean duration of hospitalization in the PSC group was higher than in the VAC group (P = .026, P = .034). Significant risk factors for mortality were additional operation, diabetes mellitus, and a high level of EuroSCORE.
   Conclusions: Delayed surgical closure following VAC therapy may be associated with shorter hospitalization and lower mortality in patients with deep sternal wound infection. Additional operation, diabetes mellitus, and a high level of EuroSCORE were associated with mortality.
C1 [Yumun, Gunduz] Namik Kemal Univ, Sch Med, Dept Cardiovasc Surg, Tekirdag, Turkey.
   [Erdolu, Burak; Toktas, Faruk; Eris, Cuneyt; Ay, Derih; Turk, Tamer; As, Ahmet Kagan] Bursa Yuksek Ihtisas Educ & Res Hosp, Dept Cardiovasc Surg, Bursa, Turkey.
C3 Namik Kemal University; Yuksek Ihtisas Training & Research Hospital
RP Yumun, G (通讯作者)，Namik Kemal Univ, Sch Med, Dept Cardiovasc Surg, Tekirdag, Turkey.
EM gunduzyumun@gmail.com
RI Erdolu, Burak/JYO-5975-2024; Toktaş, Faruk/AAH-3495-2019; Yümün,
   Gündüz/M-1768-2015; AS, Ahmet Kagan/ABG-9688-2021
OI Toktaş, Faruk/0000-0002-0820-3879; Yümün, Gündüz/0000-0002-1503-329X;
   AS, Ahmet Kagan/0000-0001-8098-4393; TÜRK, TAMER/0000-0003-1668-020X
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   Raja Shahzad G, 2007, Interact Cardiovasc Thorac Surg, V6, P523, DOI 10.1510/icvts.2007.157370
   Roques F, 1999, EUR J CARDIO-THORAC, V15, P816, DOI 10.1016/S1010-7940(99)00106-2
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Vos RJ, 2012, INTERACT CARDIOV TH, V14, P17, DOI 10.1093/icvts/ivr049
NR 15
TC 13
Z9 16
U1 0
U2 5
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PD AUG
PY 2014
VL 17
IS 4
BP E212
EP E216
DI 10.1532/HSF98.2014346
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA AZ0CH
UT WOS:000347913500008
PM 25179975
OA gold
DA 2026-07-24
ER
PT J
AU Kimura, M
   Nishimura, T
   Kinoshita, O
   Okada, S
   Inafuku, H
   Kyo, S
   Ono, M
AF Kimura, Mitsutoshi
   Nishimura, Takashi
   Kinoshita, Osamu
   Okada, Shuichi
   Inafuku, Hitoshi
   Kyo, Shunei
   Ono, Minoru
TI Successful Treatment of Pump Pocket Infection after Left Ventricular
   Assist Device Implantation by Negative Pressure Wound Therapy and
   Omental Transposition
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE pump pocket infection; mediastinitis; negative pressure wound therapy;
   implantable left ventricular assist device; omental transposition
ID POSTSTERNOTOMY MEDIASTINITIS; CLOSURE
AB A 52-year-old man suffering from dilated cardiomyopathy underwent implantable left ventricular assist device (LVAD) insertion as a bridge to transplantation. He presented with evidence of LVAD-related mediastinitis and pump pocket infection 57 days after the LVAD implantation. The mediastinum was reopened and irrigated. A large amount of pus was observed around the outflow and inflow conduits and in the pump pocket. Negative pressure wound therapy (NPWT) was initiated. Methicillin-resistant Staphylococcus aureus (MRSA) was isolated from blood and mediastinal pus. Enterobacter cloacae was also isolated by mediastinal pus culture after the beginning of the NPWT. Three weeks after the start of the NPWT, the pus culture became negative, and omental transposition and sternal closure were performed. Intravenous antibiotics were administered until day 42, with the treatment subsequently switched to oral antibiotics. He was discharged from the hospital on day 57 and followed up at the outpatient clinic. Our findings suggest that NPWT followed by omental transposition be useful to treat mediastinitis or pump pocket infection after implantable LVAD insertion.
C1 [Kimura, Mitsutoshi; Nishimura, Takashi; Kyo, Shunei] Univ Tokyo, Dept Therapeut Strategy Heart Failure, Tokyo 1138655, Japan.
   [Kinoshita, Osamu; Ono, Minoru] Univ Tokyo, Dept Cardiothorac Surg, Tokyo 1138655, Japan.
   [Okada, Shuichi] Gunma Prefectural Cardiovasc Ctr, Div Cardiovasc Surg, Gunma, Japan.
   [Inafuku, Hitoshi] Univ Ryukyus, Div Thorac & Cardiovasc Surg, Nishihara, Okinawa 90301, Japan.
C3 University of Tokyo; University of Tokyo; University of the Ryukyus
RP Nishimura, T (通讯作者)，Univ Tokyo, Dept Therapeut Strategy Heart Failure, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM takashin-tky@umin.ac.jp
OI Kimura, Mitsutoshi/0009-0007-9071-4400
FU Sun Medical Technology Research Corp. (Nagano, Japan)
FX Mitsutoshi Kimura, Takashi Nishimura, and Shunei Kyo belong to
   Department of Therapeutic Strategy for Heart Failure, which is an
   endowed department sponsored by 13 companies including Sun Medical
   Technology Research Corp. (Nagano, Japan).
CR Kawata M, 2011, J ARTIF ORGANS, V14, P159, DOI 10.1007/s10047-011-0555-y
   Kinoshita O, 2010, J ARTIF ORGANS, V13, P126, DOI 10.1007/s10047-010-0500-5
   Kurihara C, 2011, J ARTIF ORGANS, V14, P155, DOI 10.1007/s10047-010-0550-8
   Lahpor J, 2010, EUR J CARDIO-THORAC, V37, P357, DOI 10.1016/j.ejcts.2009.05.043
   Manahan MA, 2006, ANN PLAS SURG, V57, P435, DOI 10.1097/01.sap.0000221545.83524.46
   Matsumiya G, 2003, ANN THORAC SURG, V75, P287, DOI 10.1016/S0003-4975(02)04169-3
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Parissis H, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-111
   Saiki Yoshikatsu, 2008, Interact Cardiovasc Thorac Surg, V7, P712, DOI 10.1510/icvts.2008.176727
   Shafii AE, 2011, J HEART LUNG TRANSPL, V30, P1421, DOI 10.1016/j.healun.2011.08.007
   Simon D, 2005, CLIN INFECT DIS, V40, P1108, DOI 10.1086/428728
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Topkara VK, 2010, ANN THORAC SURG, V90, P1270, DOI 10.1016/j.athoracsur.2010.04.093
NR 13
TC 18
Z9 20
U1 0
U2 1
PU MEDICAL TRIBUNE INC
PI TOKYO
PA ED COMM ANNALS THORACIC CARDIOVASCULAR SURG, 2-1-30 KUDAN MINAMI,
   CHIYODA-KU, TOKYO, 102-0074, JAPAN
SN 1341-1098
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2014
VL 20
SU S
BP 842
EP 845
DI 10.5761/atcs.cr.12.02192
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA AZ1AO
UT WOS:000347973000110
PM 23535582
OA gold
DA 2026-07-24
ER
PT J
AU Aydin, U
   Gorur, A
   Findik, O
   Yildirim, A
   Kocogullari, CU
AF Aydin, Ufuk
   Gorur, Alper
   Findik, Orhan
   Yildirim, Abdullah
   Kocogullari, Cevdet Ugur
TI Therapeutic efficacy of vacuum-assisted-closure therapy in the treatment
   of lymphatic complications following peripheral vascular interventions
   and surgeries
SO VASCULAR
LA English
DT Article
DE Lymphatic system; complication; vacuum-assisted closure
ID PRESSURE WOUND THERAPY; GROIN; INFECTIONS; LYMPHORRHEA; LYMPHOCELE;
   GRAFT
AB Objectives Lymphatic complications, lymphocele and lymphorrhea being the leading, are generally encountered after vascular interventions and surgeries. The present study aimed to evaluate the outcomes of vacuum-assisted-closure (VAC) therapy, which we frequently prefer as the first-choice treatment for such complications.
   Materials and methods Among patients undergoing peripheral vascular intervention or surgery between January 2008 and February 2012, the medical files of 21 patients who received VAC therapy or other treatment due to symptomatic lymphatic complications were retrospectively analyzed and the results were discussed.
   Results Group I consisted of 10 patients (three with lymphocele and seven with lymphorrhea) who underwent VAC therapy as the first-choice treatment, Group II consisted of 11 patients of which 7 patients received various therapies before VAC therapy and 4 patients received other treatments alone. The patients who received VAC therapy as the primary therapy demonstrated more rapid wound healing, early drainage control, and shorter hospital stay. The mean hospital medical cost was Euro1038 (range, Euro739-1826) for the patients who primarily underwent VAC therapy; it was calculated to be Euro2137 (range, Euro1610-3130) for the other patients (p=0.001).
   Conclusion In addition to its safety and good clinical outcomes, VAC therapy also has economic advantages and should be the primary method for the treatment of lymphatic complications.
C1 [Aydin, Ufuk; Gorur, Alper; Findik, Orhan; Kocogullari, Cevdet Ugur] Kocaeli Derince Training & Res Hosp, Dept Cardiovasc Surg, Kocaeli, Turkey.
   [Yildirim, Abdullah] Kocaeli Derince Training & Res Hosp, Dept Plast & Reconstruct Surg, Kocaeli, Turkey.
C3 Kocaeli Derince Training & Research Hospital; Kocaeli Derince Training &
   Research Hospital
RP Aydin, U (通讯作者)，Kocaeli Derince Training & Res Hosp, Dept Cardiovasc Surg, Kocaeli, Turkey.
EM nesruf@isnet.net.tr
RI Aydin, Ufuk/GRK-0110-2022; GÖRÜR, DURMUŞ ALPER/HIZ-8555-2022;
   kocogullari, cevdet ugur/KRP-5775-2024; findik, orhan/LZH-3310-2025
OI Aydin, Ufuk/0000-0002-4083-6211; GÖRÜR, DURMUŞ
   ALPER/0000-0002-0004-173X; kocogullari, cevdet ugur/0000-0002-6303-2478;
   
CR Abai B, 2007, J VASC SURG, V45, P610, DOI 10.1016/j.jvs.2006.10.043
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   Beno M, 2011, BRATISL MED J, V112, P249
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   Chang WH, 2010, KOREAN J THORAC CARD, V43, P562
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NR 18
TC 11
Z9 15
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD FEB
PY 2015
VL 23
IS 1
BP 41
EP 46
DI 10.1177/1708538114529950
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AZ3BH
UT WOS:000348102300006
PM 24676535
DA 2026-07-24
ER
PT J
AU Miranda-Díaz, AG
   Hermosillo-Sandoval, JM
   Gutiérrez-Martínez, CA
   Rodríguez-Carrizalez, AD
   Román-Pintos, LM
   Cardona-Muñoz, EG
   Pacheco-Moisés, FP
   Arias-Carvajal, O
AF Guillermina Miranda-Diaz, Alejandra
   Manuel Hermosillo-Sandoval, Jose
   Alberto Gutierrez-Martinez, Carlos
   Daniel Rodriguez-Carrizalez, Adolfo
   Miguel Roman-Pintos, Luis
   German Cardona-Munoz, Ernesto
   Paul Pacheco-Moises, Fermin
   Arias-Carvajal, Oscar
TI Effect of necrosectomy and vacuum-assisted closure (VAC) on
   mitochondrial function and oxidative stress markers in severe acute
   pancreatitis
SO REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
LA Spanish
DT Article
DE Acute pancreatitis; Mitochondrial dysfunction; Oxidative stress; Severe
   acute pancreatitis
ID NITRIC-OXIDE; CLINICAL CHARACTERISTICS; SUPEROXIDE-DISMUTASE;
   MEMBRANE-FLUIDITY; FREE-RADICALS; ATP SYNTHASE; ABNORMALITIES;
   ANTIOXIDANT; METABOLISM; PREDICTION
AB Background: Severe acute pancreatitis (SAP) is associated with high morbidity and mortality.
   Objective: To evaluate whether necrosectomy, alone or combined with vacuum-assisted closure (VAC), has any additional beneficial effects on mitochondrial function and/or oxidative stress markers in SAP.
   Methods: Patients with SAP, APACHE II score > 8, and inadequate response to management in an intensive care unit were included in a prospective observational study. Sixteen underwent necrosectomy and 24 underwent necrosectomy plus VAC every 48 h. Patients were then categorized as survivors or deceased. Submitochondrial membrane fluidity of platelets and F0F1-ATPase hydrolysis were measured to represent mitochondrial function. Oxidative/nitrosative stress was measured using lipoperoxides (LPOs), nitric oxide (NO), erythrocyte membrane fluidity, and total antioxidant capacity (TAC).
   Results: Membrane fluidity in submitochondrial particles of platelets remained significantly increased throughout the study, and then eventually rised in deceased patients managed with necrosectomy + VAC vs. survivors (p < 0.041). Hydrolysis was significantly increased from baseline to endpoint in all patients, predominating in those who died after management with necrosectomy (p < 0.03). LPO increased in all patients, and necrosectomy was more efficient for the eventual decrease in survivors (p < 0.039). NO was found to be increased for the baseline-endpoint result among both survivors and deceased patients with both management options. Erythrocyte membrane fluidity was increased in survivors managed with necrosectomy + VAC, and eventually returned to normal (p < 0.045). TAC was found to be consumed in all patients for the duration of the study.
   Conclusions: Mitochondrial dysfunction and oxidative/nitrosative stress with significant systemic antioxidant consumption were found. Necrosectomy was more efficient and better cleared LPOs. Necrosectomy + VAC improved erythrocyte membrane fluidity and increased survival.
C1 [Guillermina Miranda-Diaz, Alejandra; Daniel Rodriguez-Carrizalez, Adolfo; Miguel Roman-Pintos, Luis; German Cardona-Munoz, Ernesto; Arias-Carvajal, Oscar] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Fisiol, Guadalajara 44430, Jalisco, Mexico.
   [Manuel Hermosillo-Sandoval, Jose] Inst Mexicano Seguro Social, Hosp Especialidades, Ctr Med Nacl Occidente, Dept Cirugia Gen, Guadalajara, Jalisco, Mexico.
   [Alberto Gutierrez-Martinez, Carlos] Inst Mexicano Seguro Social, Hosp Especialidades, Ctr Med Nacl Occidente, Unidad Cuidados Intens, Guadalajara, Jalisco, Mexico.
   [Paul Pacheco-Moises, Fermin] Univ Guadalajara, Dept Quim, Guadalajara 44430, Jalisco, Mexico.
C3 Universidad de Guadalajara; Instituto Mexicano del Seguro Social;
   Instituto Mexicano del Seguro Social; Universidad de Guadalajara
RP Miranda-Díaz, AG (通讯作者)，Univ Guadalajara, Ctr Univ Ciencias Salud, Guadalajara 44430, Jalisco, Mexico.
EM kindalex1@outlook.com
RI Román Pintos, Luis Miguel/B-8464-2014; pacheco-moises,
   fermin/ISB-3118-2023
OI Román Pintos, Luis Miguel/0000-0002-5180-3810; CARDONA MUÑOZ, ERNESTO
   GERMAN/0000-0001-7868-667X; pacheco-moises, fermin/0000-0002-3769-5649
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NR 39
TC 1
Z9 2
U1 0
U2 4
PU ARAN EDICIONES, S A
PI MADRID
PA CASTELLO, 128, 1O, 28006 MADRID, SPAIN
SN 1130-0108
EI 2340-4167
J9 REV ESP ENFERM DIG
JI Rev. Esp. Enferm. Dig.
PD SEP-DEC
PY 2014
VL 106
IS 8
BP 505
EP 514
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AZ5OQ
UT WOS:000348270400002
PM 25544407
DA 2026-07-24
ER
PT J
AU Nolff, MC
   Fehr, M
   Bolling, A
   Dening, R
   Kramer, S
   Reese, S
   Meyer-Lindenberg, A
AF Nolff, M. C.
   Fehr, M.
   Bolling, A.
   Dening, R.
   Kramer, S.
   Reese, S.
   Meyer-Lindenberg, A.
TI Negative pressure wound therapy, silver coated foam dressing and
   conventional bandages in open wound treatment in dogs
SO VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
LA English
DT Article
DE Negative pressure wound therapy; foam dressing; bacterial wound
   contamination; open wound management; wound bed preparation
ID VACUUM-ASSISTED CLOSURE; SEPTIC PERITONITIS; MANAGEMENT; SKIN; VIABILITY
AB Objectives: To evaluate negative pressure wound therapy (NPWT) for treatment of complicated wounds in dogs.
   Study type: Retrospective multicentre study.
   Materials and methods: Dogs (n = 50) undergoing open wound treatment were classified according to treatment method used: bandage (Group A, n = 7), NPWT (Group B, n = 18), and foam dressing (Group C, n = 25). Pairs of patients matched based on wound conformation, localization, and underlying cause were compared between Group A and C (n = 7 pairs) and between groups B and C (n = 18 pairs) in terms of duration of previous treatment, time to closure, and complications.
   Results: Signalment, antibiotic medications, antiseptic treatment, and bacterial status of wounds were comparable between groups. The duration of previous treatment was significantly higher in patients assigned to Group B (p = 0.04) compared to Group C, while no significant difference was found between groups A and B. Total time to wound closure was significantly shorter in Group C compared to Group A (p = 0.02) and in Group B compared to Group C (p = 0.003). Wounds treated with NPWT suffered significantly less complications (p = 0.008) and were significantly less septic during treatment (p = 0.016) than wounds treated with a foam dressing.
   Conclusion: This study shows that time to healing was halved in NPWT treated patients compared to foam dressing treated patients, which in turn healed faster than patients treated with conventional bandage, underlining the value of NPWT therapy for the treatment of complicated wounds.
C1 [Nolff, M. C.; Meyer-Lindenberg, A.] Univ Munich, Clin Small Anim Surg & Reprod, D-80539 Munich, Germany.
   [Fehr, M.; Bolling, A.; Dening, R.; Kramer, S.] Univ Vet Med Hanover, Small Anim Clin, Hannover, NH, Germany.
   [Reese, S.] Univ Munich, Dept Vet Basic Sci, D-80539 Munich, Germany.
C3 University of Munich; University of Veterinary Medicine Hannover;
   University of Munich
RP Nolff, MC (通讯作者)，Univ Munich, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Germany.
EM m.nolff@lmu.de
RI Reese, Sven/F-1826-2016; Nolff, Mirja/W-6756-2019; Meyer-Lindenberg,
   Andrea/H-1076-2011
OI Reese, Sven/0000-0002-4605-9791; Nolff, Mirja/0000-0001-9317-7769;
   Meyer-Lindenberg, Andrea/0000-0001-6137-3773
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   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
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NR 38
TC 23
Z9 26
U1 1
U2 41
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0932-0814
EI 2567-6911
J9 VET COMP ORTHOPAED
JI Vet. Comp. Orthop. Traumatol.
PY 2015
VL 28
IS 1
BP 30
EP 38
DI 10.3415/VCOT-14-05-0076
PG 9
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA AZ8UK
UT WOS:000348489700007
PM 25449799
DA 2026-07-24
ER
PT J
AU Sea, S
   Meckmongkol, T
   Moront, ML
   Timmapuri, S
   Prasad, R
   Schwartz, MZ
   Arthur, LG
AF Sea, Stephanie
   Meckmongkol, Teerin
   Moront, Matthew L.
   Timmapuri, Shaheen
   Prasad, Rajeev
   Schwartz, Marshall Z.
   Arthur, L. Grier
TI Vacuum-Assisted Closure: A Novel Method of Managing Surgical Necrotizing
   Enterocolitis
SO EUROPEAN JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE necrotizing enterocolitis; abdominal compartment syndrome;
   vacuum-assisted closure
ID ABDOMINAL COMPARTMENT SYNDROME; NEGATIVE-PRESSURE; MANAGEMENT; THERAPY
AB PurposeNecrotizing enterocolitis (NEC) requiring surgical intervention is associated with mortality rates approaching 50%. We evaluated outcomes of patients that underwent surgical treatment for NEC with vacuum-assisted closure (VAC) of the abdomen as compared with traditional laparotomy, bowel resection, and ostomy creation.
   MethodsA retrospective review identified 26 patients from 2007 to 2012 with NEC. Overall, 17 patients were treated with laparotomy, and 9 were treated with laparotomy and VAC (LapVac). Age, weight, preoperative and postoperative mean airway pressure, length of bowel resected, duration on total peripheral nutrition, time until initiation of feeds, and length of stay were assessed. A Student's t-test was used for statistical analysis.
   ResultsNine LapVac patients underwent a total of 1.21.3 VAC changes and had open abdomens for 13.1 +/- 19.1 days. LapVac and traditional laparotomy patients had similar outcomes with respect to amount of bowel resected, time on a ventilator, time to initiation of feeds, and length of hospital stay. Two of nine patients (22%) in the LapVac group were placed in continuity without the need for an ostomy. We identified a subset of patients in the LapVac group that demonstrated signs of abdominal compartment syndrome (ACS), exhibiting mean airway pressures greater than 15 cm H2O preoperatively. Patients with ACS treated with VAC therapy had shorter time to initiation of feeds (p=0.047) and shorter lengths of stay (p=0.0395) as compared with traditional laparotomy.
   ConclusionOur data demonstrate that use of the wound VAC is a safe approach in the management of premature infants with NEC requiring surgical intervention with outcomes comparable to standard surgical management. Use of the wound VAC may allow the establishment of bowel continuity and abdominal closure without the need for an ostomy. VAC therapy may also hasten the recovery of NEC patients with concomitant ACS by eliminating the compartment syndrome. Larger studies are required to confirm this theory.
C1 [Sea, Stephanie; Meckmongkol, Teerin; Moront, Matthew L.; Timmapuri, Shaheen; Prasad, Rajeev; Schwartz, Marshall Z.; Arthur, L. Grier] St Christophers Hosp Children, Dept Pediat Surg, Philadelphia, PA 19134 USA.
RP Sea, S (通讯作者)，St Christophers Hosp Children, Dept Pediat Surg, 3601 A St, Philadelphia, PA 19134 USA.
EM stephanieasea@gmail.com; Grier.Arthur@tenethealth.com
OI Meckmongkol, Teerin/0000-0003-4868-1725
CR Amin AI, 2009, WORLD J GASTROENTERO, V15, P3394, DOI 10.3748/wjg.15.3394
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NR 17
TC 10
Z9 13
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0939-7248
EI 1439-359X
J9 EUR J PEDIATR SURG
JI Eur. J. Pediatr. Surg.
PD FEB
PY 2015
VL 25
IS 1
BP 41
EP 45
DI 10.1055/s-0034-1387940
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA AZ9HL
UT WOS:000348524500010
PM 25172983
OA Bronze
DA 2026-07-24
ER
PT J
AU Echebiri, NC
   McDoom, MM
   Aalto, MM
   Fauntleroy, J
   Nagappan, N
   Barnabei, VM
AF Echebiri, Nelson C.
   McDoom, M. Maya
   Aalto, Meaghan M.
   Fauntleroy, Jessie
   Nagappan, Nagammai
   Barnabei, Vanessa M.
TI Prophylactic Use of Negative Pressure Wound Therapy After Cesarean
   Delivery
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID SURGICAL SITE INFECTION; MEDICAL DECISION-ANALYSIS; RISK-FACTORS;
   POSTDISCHARGE SURVEILLANCE; LAPAROTOMY INCISIONS; SECTION; PRIMER;
   VACUUM; PREVENTION; MANAGEMENT
AB OBJECTIVE: To evaluate the economic benefit of prophylactic negative pressure wound therapy on a closed laparotomy incision after cesarean delivery in comparison with standard postoperative dressing.
   METHODS: We designed a decision-analytic model from a third-party payer's perspective to determine the cost-benefit of prophylactic application of negative pressure wound therapy compared with standard postoperative dressing on a closed laparotomy incision after cesarean delivery. Our primary outcome measure was the expected value of the cost per strategy. Baseline probabilities and cost assumptions were derived from published literature. We conducted sensitivity analyses using both deterministic and probabilistic models. Cost estimates reflect 2014 U. S. dollars.
   RESULTS: Under our baseline parameters, standard postoperative dressing was the preferred strategy. Standard postoperative dressing and prophylactic negative pressure wound therapy cost $547 and $804 per strategy, respectively. Sensitivity analyses showed that prophylactic negative pressure wound therapy can be cost-beneficial if it is priced below $192; standard postoperative dressing is the preferred strategy among patients with surgical site infection rate of 14% or less. If surgical site infection rates are greater than 14%, prophylactic negative pressure wound therapy could be cost-beneficial depending on the degree of reduction in surgical site infections. At a surgical site infection rate of 30%, the rate must be reduced by 15% for negative pressure wound therapy to become the preferred strategy. Monte Carlo simulation of 1,000 patients in 1 million trials showed that standard postoperative dressing was the preferred cost-beneficial strategy with a frequency of 85%.
   CONCLUSION: Our cost-benefit analysis provides economic evidence suggesting that negative pressure wound therapy should not be used on closed laparotomy incisions of patients with low risk of postcesarean delivery surgical site infections. However, among patients with a high risk of surgical site infections, prophylactic negative pressure wound therapy is potentially cost-beneficial.
C1 SUNY Buffalo, Dept Obstet & Gynecol, Buffalo, NY 14221 USA.
   Mississippi State Univ, Social Sci Res Ctr, Starkville, MS USA.
   Harvard Univ, Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA 02115 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Mississippi State University; Harvard University; Harvard T.H. Chan
   School of Public Health
RP Echebiri, NC (通讯作者)，SUNY Buffalo, Dept Obstet Gynecol, 219 Bryant St, Buffalo, NY 14221 USA.
EM nelsonechebiri@gmail.com
OI Barnabei, Vanessa/0000-0002-9650-0143
CR Alanis MC, 2010, AM J OBSTET GYNECOL, V203
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NR 41
TC 38
Z9 42
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD FEB
PY 2015
VL 125
IS 2
BP 299
EP 307
DI 10.1097/AOG.0000000000000634
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CA0GR
UT WOS:000348595500004
PM 25569006
DA 2026-07-24
ER
PT J
AU Bollero, D
   Malvasio, V
   Catalano, F
   Stella, M
AF Bollero, Daniele
   Malvasio, Valeria
   Catalano, Fabio
   Stella, Maurizio
TI Negative-pressure surgical management after pathological scar surgical
   excision: a first report
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Prevena; Scar; Wound healing
ID CLOSED INCISION MANAGEMENT; WOUND THERAPY; HYPERTROPHIC SCARS;
   PATHOPHYSIOLOGY; INFECTION; SURGERY
AB Wound dehiscence is a surgical complication caused by the application of opposing and distracting forces tending to pull apart the suture line. In recent years, a novel negative pressure surgical management system has been developed to prevent surgical wound complications. This system creates a closed environment that removes exudates and other potentially infectious material, protects the surgical site from external contamination, provides support in holding the edges of the incision together and promotes wound healing. In this study, we describe our first experience with Prevena, a closed incision negative pressure management system used on suture line following wide pathological scars excision for the prevention of postoperative wound dehiscence. Eight patients with wide and mature pathological skin scars were treated with Prevena. The device was positioned directly after surgical correction for 8 days with a continuous application of -125 mmHg negative pressure. All treated patients had no postoperative surgical wound dehiscence. In one case, a limit of the device was represented by its poor adherence on hairy surface, hampering the maintenance of an appropriate local negative pressure. In another case, suture line was longer than Prevena foam and it was covered partially. Prevena system appears to be safe, easy to use and may represent a support technique to wide pathological skin scars surgical correction.
C1 [Bollero, Daniele; Malvasio, Valeria; Catalano, Fabio; Stella, Maurizio] CTO Hosp, Burn Ctr, Dept Plast Surg, Turin, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino
RP Bollero, D (通讯作者)，CTO Hosp, Burn Ctr, Dept Plast Surg, Turin, Italy.
EM info@danielebollero.it
RI Stella, Maurizio/JGD-2010-2023
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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   Wolfram D, 2009, DERMATOL SURG, V35, P171, DOI 10.1111/j.1524-4725.2008.34406.x
NR 26
TC 19
Z9 22
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2015
VL 12
IS 1
BP 17
EP 21
DI 10.1111/iwj.12040
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CA4CK
UT WOS:000348851700004
PM 23418720
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Malmsjö, M
   Hlebowicz, J
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Hlebowicz, Joanna
   Ingemansson, Richard
TI Comparative study of the microvascular blood flow in the intestinal
   wall, wound contraction and fluid evacuation during negative pressure
   wound therapy in laparostomy using the VAC abdominal dressing and the
   ABThera open abdomen negative pressure therapy system
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE ABThera; Fluid evacuation; Microvascular blood flow; NPWT; Open abdomen;
   VAC
ID ASSISTED CLOSURE; COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION;
   PROTECTIVE DISC; RECOMMENDATIONS; SEPSIS
AB To compare the changes in microvascular blood flow in the small intestinal wall, wound contraction and fluid evacuation, using the established V.A.C. abdominal dressing (VAC dressing) and a new abdominal dressing, the ABThera open abdomen negative pressure therapy system (ABThera dressing), in negative pressure wound therapy (NPWT). Midline incisions were made in 12 pigs, which were subjected to treatment with NPWT using the VAC or ABThera dressing. The microvascular blood flow in the intestinal wall, were measured before and after the application at topical negative pressures of -50, -75 and -125 mmHg, using laser Doppler velocimetry. Wound contraction and fluid evacuation were also measured. Baseline blood flow was defined as 100% in all settings. The blood flow was significantly reduced, to 646 +/- 67% (P < 005) after the application of -50 mmHg using the VAC dressing, and to 653 +/- 96% (P < 005) after the application of -50 mmHg with the ABThera dressing. The blood flow was significantly reduced, to 396 +/- 67% (P < 005) after the application of -125 mmHg using VAC, and to 405 +/- 62% (P < 005) after the application of -125 mmHg with ABThera. No significant difference in the reduction in blood flow could be observed between the two groups. The ABThera system gave significantly better fluid evacuation from the wound compared to the VAC system. There was no difference between the dressings regarding the reduction in blood flow, but the ABThera dressing afforded better drainage of the abdomen and better wound contraction than the VAC dressing.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
   [Lindstedt, Sandra; Malmsjo, Malin; Hlebowicz, Joanna; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, SE-22185 Lund, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, SE-22185 Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University
RP Lindstedt, S (通讯作者)，Lund Univ, SUS, Skane Univ Hosp, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM sandra.lindstedt@med.lu.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953; Lindstedt, Sandra/0000-0003-4484-6473
CR Becker HP, 2007, SCAND J SURG, V96, P263, DOI 10.1177/145749690709600402
   Bee TK, 2008, J TRAUMA, V65, P337, DOI 10.1097/TA.0b013e31817fa451
   Cheatham ML, 2007, INTENS CARE MED, V33, P951, DOI 10.1007/s00134-007-0592-4
   Deenichin GP, 2008, SURG TODAY, V38, P5, DOI 10.1007/s00595-007-3573-x
   Fischer JE, 2008, AM J SURG, V196, P1, DOI 10.1016/j.amjsurg.2008.01.001
   Hlebowicz J, 2012, INT J COLORECTAL DIS, V27, P397, DOI 10.1007/s00384-011-1317-2
   Lindstedt S, 2012, BMC SURG, V12, DOI 10.1186/1471-2482-12-4
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NR 18
TC 20
Z9 22
U1 0
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2015
VL 12
IS 1
BP 83
EP 88
DI 10.1111/iwj.12056
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CA4CK
UT WOS:000348851700014
PM 23517436
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Upton, D
   Andrews, A
AF Upton, Dominic
   Andrews, Abbye
TI Pain and trauma in negative pressure wound therapy: a review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Pain; Skin; tissue damage; Trauma;
   Wound
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; CLINICAL-EXPERIENCE;
   MANAGEMENT; INFECTIONS; PATIENT; GRAFTS; STRESS; IMPACT; STATE
AB Negative pressure wound therapy (NPWT) is considered an effective wound treatment, but there are a number of issues that need to be addressed for improvements to be made. This review aimed to explore the literature relating to the pain and skin trauma that may be experienced during NPWT. A literature search was carried out using the following databases: Academic Search Complete, CINAHL, PsychINFO, MEDLINE and PsyARTICLES. A total of 30 articles were reviewed. Studies reported varying levels of pain in patients undergoing NPWT, with certain treatment factors affecting the level of pain, such as the NPWT system and the dressing/filler used. Similarly, although there is much less research exploring NPWT-related trauma, findings suggest that dressing and filler type may impact on whether trauma occurs. However, further research needs to consider the different stages of NPWT and how pain and trauma can be minimised during the whole procedure. As both pain and skin trauma impact on the patient's well-being and on wound healing, it is essential that research further explores the factors that may affect the experience of pain and trauma, so as to inform developments in wound care.
C1 [Upton, Dominic; Andrews, Abbye] Univ Worcester, Inst Hlth & Soc, Worcester WR2 6AJ, England.
C3 University of Worcester
RP Upton, D (通讯作者)，Univ Worcester, Inst Hlth & Soc, Worcester WR2 6AJ, England.
EM d.upton@worc.ac.uk
OI Upton, Dominic/0000-0002-5547-6204
CR Abbotts Joanne, 2010, Br J Nurs, V19, pS37
   [Anonymous], 2008, COCHRANE DATABASE SY
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   Verbelen J, 2011, WOUNDS, V23, P342
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
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   Wu SC, 2008, INT WOUND J, V5, P10, DOI 10.1111/j.1742-481X.2008.00466.x
NR 42
TC 38
Z9 41
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2015
VL 12
IS 1
BP 100
EP 105
DI 10.1111/iwj.12059
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CA4CK
UT WOS:000348851700016
PM 23489350
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Filippelli, S
   Perri, G
   Brancaccio, G
   Iodice, FG
   Albanese, SB
   Trimarchi, E
   Carotti, A
AF Filippelli, Sergio
   Perri, Gianluigi
   Brancaccio, Gianluca
   Iodice, Francesca G.
   Albanese, Sonia B.
   Trimarchi, Eugenio
   Carotti, Adriano
TI Vacuum-Assisted Closure System in Newborns After Cardiac Surgery
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID POSTSTERNOTOMY MEDIASTINITIS; WOUND-INFECTION; EXPERIENCE
AB ObjectiveTo analyze the effectiveness and the results of the use of a vacuum-assisted closure (VAC) system for the treatment of complex sternal wounds in newborns after cardiac surgery.
   MethodsFrom May 2008 until December 2012, six patients developed post-sternotomy wound problems (large defects of epithelialization or mediastinitis), which were treated with a VAC system. Median age at the time of institution of VAC was 24.5 days (range 16 to 65 days). Median time of treatment was 14 days (range 3 to 42 days).
   ResultsAll patients were newborns and all underwent delayed sternal closure after cardiac surgery. The indications for using the VAC system were: mediastinitis in two patients (33.3%) and impairment of healing without signs of infection in four (66.7%). All children after VAC therapy achieved healing of the sternal wound. VAC therapy was started with high negative pressures (-125mmHg) continuously then switched to an intermittent modality in all patients.
   ConclusionVAC system with high negative pressure is safe, effective, and is a well-tolerated therapy in newborns with complex sternal wounds. doi: 10.1111/jocs.12463 (J Card Surg 2015;30:190-193)
C1 [Filippelli, Sergio; Perri, Gianluigi; Brancaccio, Gianluca; Iodice, Francesca G.; Albanese, Sonia B.; Carotti, Adriano] Bambino Gesu Pediat Hosp, IRCCS, Dept Pediat Cardiol & Cardiac Surg, I-00165 Rome, Italy.
   [Trimarchi, Eugenio] San Vincenzo Hosp, Pediat Cardiac Surg Unit, Taormina, Italy.
C3 IRCCS Bambino Gesu
RP Perri, G (通讯作者)，Bambino Gesu Pediat Hosp, IRCCS, Dept Pediat Cardiac Surg, Piazza S Onofrio 4, I-00165 Rome, Italy.
EM dr.gianluigiperri@gmail.com
RI Carotti, Adriano/AAR-8567-2021
OI Iodice, Francesca Giovanna/0000-0002-0478-619X; Perri,
   Gianluigi/0000-0002-3787-0873; brancaccio, gianluca/0000-0001-8113-6513;
   Albanese, Sonia/0000-0002-9064-6651
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NR 18
TC 6
Z9 9
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD FEB
PY 2015
VL 30
IS 2
BP 190
EP 193
DI 10.1111/jocs.12463
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA CA4UO
UT WOS:000348901200013
PM 25363601
DA 2026-07-24
ER
PT J
AU Ye, JN
   Xie, T
   Wu, MJ
   Ni, PW
   Lu, SL
AF Ye, Junna
   Xie, Ting
   Wu, Minjie
   Ni, Pengwen
   Lu, Shuliang
TI Negative Pressure Wound Therapy Applied Before and After Split-Thickness
   Skin Graft Helps Healing of Fournier Gangrene A Case Report
   (CARE-Compliant)
SO MEDICINE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TRIAL
AB Fournier gangrene is a rare but highly infectious disease characterized by fulminant necrotizing fasciitis involving the genital and perineal regions. Negative pressure wound therapy (NPWT; KCI USA Inc, San Antonio, TX) is a widely adopted technique in many clinical settings. Nevertheless, its application and effect in the treatment of Fournier gangrene are unclear.
   A 47-year-old male patient was admitted with an anal abscess followed by a spread of the infection to the scrotum, which was caused by Pseudomonas aeruginosa. NPWT was applied on the surface of the scrotal area and continued for 10 days. A split-thickness skin graft from the scalp was then grafted to the wound, after which, NPWT utilizing gauze sealed with an occlusive dressing and connected to a wall suction was employed for 7 days to secure the skin graft.
   At discharge, the percentage of the grafted skin alive on the scrotum was 98%. The wound beside the anus had decreased to 4 x 0.5 cm with a depth of 1 cm. Follow-up at the clinic 1 month later showed that both wounds had healed. The patient did not complain of any pain or bleeding, and was satisfied with the outcome.
   NPWT before and after split-thickness skin grafts is safe, well tolerated, and efficacious in the treatment of Fournier gangrene.
C1 [Ye, Junna; Lu, Shuliang] Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Burns, Shanghai 200030, Peoples R China.
   [Xie, Ting; Wu, Minjie; Ni, Pengwen] Shanghai Jiao Tong Univ, Sch Med, Shanghai Hosp 9, Dept Wound Healing, Shanghai 200030, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Lu, SL (通讯作者)，197 RuiJin 2nd Rd, Shanghai 200025, Peoples R China.
EM 13901738685@139.com
RI Ye, Junna/ABF-6141-2020
FU Shanghai Excellent Youth Teacher Cultivation Program; National Science
   and Technology Support Program of China [2012BAI11B04]
FX This work was supported by Shanghai Excellent Youth Teacher Cultivation
   Program and National Science and Technology Support Program of China
   (No. 2012BAI11B04).
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NR 16
TC 19
Z9 23
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB
PY 2015
VL 94
IS 5
AR e426
DI 10.1097/MD.0000000000000426
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CA6DZ
UT WOS:000349000400004
PM 25654376
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Maguire, P
   Azagrar, JM
   Carb, A
   Lesser, A
AF Maguire, Patrick
   Azagrar, Joseph M.
   Carb, Allan
   Lesser, Arnold
TI The Successful Use of Negative-Pressure Wound Therapy in Two Cases of
   Canine Necrotizing Fasciitis
SO JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MANUKA HONEY
AB A 5 mo old female Akita and a 1 yr, 5 mo old male German shorthaired pointer were both evaluated for soft-tissue lesions characterized by rapidly expanding edema, erythema, and pain. Ultrasound was utilized to locate and sample fluid accumulations, and beta-hemolytic Streptococcus was isolated from the wounds. Development of systemic symptoms including fever, tachycardia, and tachypnea as well as a lack of response to medical management prompted surgical intervention in both cases. During surgical exploration and debridement, disruption of intermuscular tissue planes was appreciated and necrotizing fasciitis (NF) was suspected. Negative-pressure wound therapy systems utilizing 120 mm Hg of continual negative pressure were applied to wounds for 5 and 4 days for the Akita and German shorthaired pointer, respectively. Resolution of infection was achieved and although the lesions were associated with limbs, amputation was avoided. In both cases, the results of histopathology were consistent with NF. NF is recognized as a rapidly progressive infection associated with high rates of morbidity and mortality. Timely use of negative-pressure wound therapy appears to be a viable management tool to accompany surgical debridement, appropriate antibiotics, and analgesics.
C1 [Maguire, Patrick; Azagrar, Joseph M.; Carb, Allan; Lesser, Arnold] New York Vet Specialty Ctr, Farmingdale, NY 11735 USA.
RP Maguire, P (通讯作者)，New York Vet Specialty Ctr, Farmingdale, NY 11735 USA.
EM PatrickMaguire7606@gmail.com
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NR 16
TC 5
Z9 5
U1 0
U2 19
PU AMER ANIMAL HOSPITAL ASSOC
PI LAKEWOOD
PA PO BOX 150899, LAKEWOOD, CO 80215-0899 USA
SN 0587-2871
EI 1547-3317
J9 J AM ANIM HOSP ASSOC
JI J. Am. Anim. Hosp. Assoc.
PD JAN-FEB
PY 2015
VL 51
IS 1
BP 43
EP 48
DI 10.5326/JAAHA-MS-6033
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CA9FU
UT WOS:000349228000008
PM 25415211
DA 2026-07-24
ER
PT J
AU Schwartz, JA
   Goss, SG
   Facchin, F
   Gendics, C
   Lantis, JC
AF Schwartz, J. A.
   Goss, S. G.
   Facchin, F.
   Gendics, C.
   Lantis, J. C.
TI Single-use negative pressure wound therapy for the treatment of chronic
   lower leg wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; chronic wounds; single-use negative
   pressure wound therapy; pressure ulcers; diabetic foot ulcers; venous
   leg ulcers
ID VACUUM-ASSISTED CLOSURE; ULCERS
AB Objective: Lower extremity ulcers are caused by multiple disease processes and contribute to a high level of patient morbidity and health-care spending in the US. Negative pressure wound therapy (NPWT) has been used extensively for wound bed preparation. Our aim is to assess the efficacy of an affordable, low-profile single-use NPWT (single-use NPWT) on chronic lower extremity wounds that would usually be deemed too small or superficial for traditional NPWT.
   Method: A prospective pilot study was undertaken in which chronic lower extremity wounds were treated with single-use NPWT. Study visits were biweekly for primary contact dressing change, with the negative pressure unit being changed weekly. Biweekly assessments were made of wound appearance, surface area, depth, exudate amount, peri-wound skin integrity, and signs of clinical infection. Digital photography was performed at each visit. Patients with venous leg ulcers (VLUs) were treated with a 3-layer wrap. Diabetic foot ulcers (DFUs) were treated with off-loading shoes.
   Results: The study recruited 12 patients. There were 13 wounds in total; two DFUs, two traumatic/postoperative/pressure ulcers, and nine VLUs. DFUs decreased in size on average 62%, VLUs by 32%, and traumatic/postoperative/pressure wounds by 74%. The wound appearance became more favourable and the wound depth decreased with the use of single-use NPWT.
   Conclusion: Single-use NPWT is a suitable therapy for chronic lower extremity wounds. Single-use NPWT led to a decrease in wound size and depth, an increased amount of granulation tissue, and a high level of patient satisfaction, with a low complication rate.
C1 [Schwartz, J. A.; Goss, S. G.; Lantis, J. C.] St Lukes Roosevelt Hosp, Dept Surg, New York, NY 10025 USA.
   [Facchin, F.] Univ Padua, Padua, Italy.
   [Gendics, C.] Mt Sinai St Lukes, New York, NY 10025 USA.
C3 Mount Sinai Morningside; Mount Sinai West; University of Padua; Mount
   Sinai Morningside
RP Schwartz, JA (通讯作者)，St Lukes Roosevelt Hosp, Dept Surg, New York, NY 10025 USA.
EM jlantis@chpnet.org
RI Facchin, Federico/GLN-4990-2022
OI Facchin, Federico/0000-0002-6695-1103
FU Smith & Nephew, Hull, UK
FX This study was funded by Smith & Nephew, Hull, UK. JC Lantis is a paid
   consultant for KCI, Smith & Nephew, Healthpoint and Macrocure. C Gendics
   is a paid consultant for Macrocure and ManukaMed.
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   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Schultz Gregory S, 2004, Int Wound J, V1, P19, DOI 10.1111/j.1742-481x.2004.00008.x
   Smith, 2012, PICO NEG PRESS WOUND
   Stockl K, 2004, DIABETES CARE, V27, P2129, DOI 10.2337/diacare.27.9.2129
   Velasco M, 2011, ACTAS DERMO-SIFILOGR, V102, P780, DOI 10.1016/j.ad.2011.05.005
   Vig S, 2011, J TISSUE VIABILITY, V20, pS1, DOI 10.1016/j.jtv.2011.07.002
NR 14
TC 6
Z9 6
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2015
VL 24
IS 2
SU S
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CB1AX
UT WOS:000349359900002
DA 2026-07-24
ER
PT J
AU Soares, KC
   Baltodano, PA
   Hicks, CW
   Cooney, CM
   Olorundare, IO
   Cornell, P
   Burce, K
   Eckhauser, FE
AF Soares, Kevin C.
   Baltodano, Pablo A.
   Hicks, Caitlin W.
   Cooney, Carisa M.
   Olorundare, Israel O.
   Cornell, Peter
   Burce, Karen
   Eckhauser, Frederic E.
TI Novel wound management system reduction of surgical site morbidity after
   ventral hernia repairs: a critical analysis
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Ventral hernia; Incisional hernia; Surgical site infection; Surgical
   site occurrence; Negative-pressure wound therapy; Vacuum-assisted
   closure
ID VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE THERAPY; INCISIONAL HERNIA;
   SUTURE REPAIR; MESH REPAIR; RISK; INFECTION; PREVENTION; COMPLICATIONS;
   SURGERY
AB BACKGROUND: Prophylactic incisional negative-pressure wound therapy use after ventral hernia repairs (VHRs) remains controversial. We assessed the impact of a modified negative-pressure wound therapy system (hybrid-VAC or HVAC) on outcomes of open VHR.
   METHODS: A 5-year retrospective analysis of all VHRs performed by a single surgeon at a single institution compared outcomes after HVAC versus standard wound dressings. Multivariable logistic regression compared surgical site infections, surgical site occurrences, morbidity, and reoperation rates.
   RESULTS: We evaluated 199 patients (115 HVAC vs 84 standard wound dressing patients). Mean follow-up was 9 months. The HVAC cohort had lower surgical site infections (9% vs 32%, P < 001) and surgical site occurrences (17% vs 42%, P = .001) rates. Rates of major morbidity (19% vs 31%, P = .04) and 90-day reoperation (5% vs 14%, P = .02) were lower in the HVAC cohort.
   CONCLUSIONS: The HVAC system is associated with optimized outcomes following open VHR. Prospective studies should validate these findings and define the economic implications of this intervention. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Soares, Kevin C.; Baltodano, Pablo A.; Hicks, Caitlin W.; Cornell, Peter; Burce, Karen; Eckhauser, Frederic E.] Johns Hopkins Univ, Dept Surg, Baltimore, MD 21218 USA.
   [Cooney, Carisa M.; Olorundare, Israel O.] Johns Hopkins Univ, Sch Med, Dept Plast & Reconstruct Surg, Baltimore, MD USA.
C3 Johns Hopkins University; Johns Hopkins University
RP Eckhauser, FE (通讯作者)，Johns Hopkins Univ, Dept Surg, Baltimore, MD 21218 USA.
EM feckhau2@jhmi.edu
RI Soares, Kevin/PII-7807-2026; Hicks, Caitlin/JAX-4080-2023
OI Hicks, Caitlin/0000-0001-7638-1936
FU KCI grant [115258]
FX This study was made possible in part through an investigator-initiated
   trial grant from KCI grant number 115258.
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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   Stoikes N, 2013, AM SURGEON, V79, P1177
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   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
NR 30
TC 55
Z9 59
U1 0
U2 6
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD FEB
PY 2015
VL 209
IS 2
BP 324
EP 332
DI 10.1016/j.amjsurg.2014.06.022
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CB6EU
UT WOS:000349720500016
PM 25194761
DA 2026-07-24
ER
PT J
AU Hafeez, K
   Haroon-ur-Rashid
   Khani, GMK
   Kumar, D
   Kumar, S
AF Hafeez, Kamran
   Haroon-ur-Rashid
   Khani, Ghulam Mustafa Kaim
   Kumar, Darshan
   Kumar, Sunil
TI Vacuum Assisted Closure- utilization as home based therapy in the
   management of complex diabetic extremity wounds
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Diabetic wound; Vacuum assisted closure; Complex lower limb wounds
ID RANDOMIZED CONTROLLED-TRIAL; FOOT ULCERS; MULTICENTER; AMPUTATION;
   IMPACT
AB Objective: Vacuum assisted closure is a reported technique to manage complex wounds. We have utilized this technique by using simple locally available material in the management of our patients on outpatient basis. The objective of this study is to present our experience.
   Methods: This study was conducted from June 2011 to June 2013 at Dow University Hospital and Aga Khan University Hospital, Karachi. There were 38 patients managed with vacuum assisted closure. Mean age was 56 7.8 years. Twenty three patients presented with necrotizing fasciitis and 15 patients with gangrene.' Lower limbs were involved in majority of the patients. Debridennent or amputations were done. Vacuum dressing was changed twice weekly in outpatient department. Wounds were closed secondarily if possible. or covered with split thickness skin graft in another admission.
   Results: All the wounds were successfully granulated at the end of vacuum therapy. Mean hospital stay was 7.5 days. Vacuum dressing was applied for a mean of 20 days. There was reduction in the size of the wound. Thirteen patients underwent secondary closure of the wound under local anesthesia, 18 patients required coverage with split thickness skin graft and 7 patients healed with secondary intention.
   Conclusion: Vacuum assisted closure appeared to be an effective method to manage complex diabetic wounds requiring sterile wound environment.
C1 [Hafeez, Kamran; Haroon-ur-Rashid] Aga Khan Univ Hosp, Karachi, Pakistan.
   [Hafeez, Kamran; Khani, Ghulam Mustafa Kaim; Kumar, Darshan; Kumar, Sunil] Dow Univ Hlth Sci, Dow Int Med Coll, Karachi, Pakistan.
C3 Aga Khan University; Dow University of Health Sciences
RP Hafeez, K (通讯作者)，Dow Univ Hlth Sci, Dow Int Med Coll, Ojha Campus Suparco Rd, Karachi, Pakistan.
EM kamranhafeez@hotmail.com
RI Hafeez, Kamran/AAN-5205-2021
OI Hafeez, Kamran/0000-0001-5098-0922
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 19
TC 4
Z9 6
U1 0
U2 6
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD JAN-FEB
PY 2015
VL 31
IS 1
BP 95
EP 99
DI 10.12669/pjms.311.6093
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CB9FD
UT WOS:000349936500019
PM 25878622
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Bi, HD
   Fang, S
   Jiang, D
   Xing, X
   Zhu, J
   Wang, XY
   Dai, HY
   Zhong, XY
   Li, JH
AF Bi, Hongda
   Fang, Shuo
   Jiang, Dong
   Xing, Xin
   Zhu, Ji
   Wang, Xiaoyun
   Dai, Haiying
   Zhong, Xueying
   Li, Junhui
TI Ultrasound-guided scraping of fibrous capsule plus bilayered negative
   pressure wound therapy for treatment of refractory postmastectomy seroma
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Seroma; Negative pressure wound therapy; Wound healing; Drainage
ID VACUUM-ASSISTED CLOSURE; BREAST-CANCER SURGERY; AXILLARY DISSECTION;
   FIBRIN SEALANT; PREVENTION; COMPLICATIONS; SUCTION; RECONSTRUCTION;
   MANAGEMENT; MASTECTOMY
AB Introduction: Seroma is a frequent complication of breast cancer surgery. Treatment of prolonged or refractory seroma remains a clinical challenge. This study aimed to evaluate the efficacy of a novel approach for refractory seroma treatment; the method combines minimally invasive scraping for fibrous capsule removal and self-designed bilayered negative pressure wound therapy (b-NPWT) to achieve favorable wound healing.
   Methods: Twenty-four patients with refractory seroma received ultrasound-guided scraping of fibrous capsule around the refractory seroma, and then a bilayered NPWT system simultaneously allowing for fluid drainage and dynamic topical pressure was manually implemented immediately. The time of NPWT application and wound healing was recorded, and pathological examination was conducted for the removed fibrous tissues.
   Results: Removal of the fibrous capsule was securely achieved by minimally invasive scraping through a 1.5-cm incision guided with ultrasound scanning. All refractory seromas in the 24 patients healed uneventfully after an average application of NPWT for 7.2 +/- 3.3 days without recurrence during the 3-12 months of follow-up. Biopsy of the removed fibrous tissue demonstrated that single-layered endothelial cells stained with CD31, D2-40, and Ki-67 existed both on the surface of and inside the fibrous tissue.
   Conclusions: The combination of fibrous capsule removal by ultrasound-guided scraping with successive bilayered NPWT therapy is effective and minimally invasive for promoting wound healing of refractory postmastectomy seroma. (C) 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Bi, Hongda; Fang, Shuo; Xing, Xin; Zhu, Ji; Wang, Xiaoyun; Dai, Haiying; Zhong, Xueying; Li, Junhui] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai 200433, Peoples R China.
   [Jiang, Dong] Second Mil Med Univ, Changhai Hosp, Dept Ultrasound, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Xing, X (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM xingxin57@163.com; Lissot@163.com
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NR 31
TC 4
Z9 6
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAR
PY 2015
VL 68
IS 3
BP 403
EP 409
DI 10.1016/j.bjps.2014.11.007
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CB9VL
UT WOS:000349981500024
PM 25547936
DA 2026-07-24
ER
PT J
AU Nolff, MC
   Flatz, KM
   Meyer-Lindenberg, A
AF Nolff, M. C.
   Flatz, K. M.
   Meyer-Lindenberg, A.
TI Preventive incisional negative pressure wound therapy (Prevena®) for an
   at-risk-surgical closure in a female Rottweiler
SO SCHWEIZER ARCHIV FUR TIERHEILKUNDE
LA English
DT Article
DE negative pressure wound therapy; closed incision wound healing
   deficiency; abscess
ID VACUUM-ASSISTED CLOSURE; CLEAN-CONTAMINATED WOUNDS; INFECTION-RATES;
   DOGS; MANAGEMENT; CATS; SKIN; SURGERY; SYSTEM
AB This case report describes a combination of negative pressure-wound-therapy (NPWT) and NPWT assisted incision management after resection of an abscess located at the right thoracic wall in a Rottweiler. The patient had a history of severe incisional complications after surgical interventions performed in the past, including repeated episodes of wound dehiscence, major skin necrosis and infection with and without a multiresistant strain of Staphylococcus aureus and several episodes of open wound management with healing rates between months and a year. Wound closure after resection of the mass was performed as a staged procedure. After two days of open NPWT the wound was primarily closed and a preventive incisional vacuum assisted therapy (CI-NPWT) was started for 7 days. The patient was discharged during therapy with the portable device in place. The Unit was removed at day 7 post wound closure, suture removal followed at day 10. Wound healing was uneventful and no major complications occurred at a follow up time of 8 months. This is the first description of closed incisional negative pressure wound therapy in the dog.
C1 [Nolff, M. C.; Flatz, K. M.; Meyer-Lindenberg, A.] Univ Munich, Clin Small Anim Surg & Reprod, Ctr Clin Vet Med, D-80539 Munich, Germany.
C3 University of Munich
RP Nolff, MC (通讯作者)，Univ Munich, Clin Small Anim Surg & Reprod, Ctr Clin Vet Med, Vet Str 13, D-80539 Munich, Germany.
EM m.nolff@lmu.de
RI ; Meyer-Lindenberg, Andrea/H-1076-2011; Nolff, Mirja/W-6756-2019
OI Flatz, Katharina Maria/0009-0008-8350-1703; Meyer-Lindenberg,
   Andrea/0000-0001-6137-3773; Nolff, Mirja/0000-0001-9317-7769
CR Adkesson MJ, 2007, JAVMA-J AM VET MED A, V231, P1249, DOI 10.2460/javma.231.8.1249
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   Frey T N., 2012, J AM VET MED ASSOC, V236, P88
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NR 24
TC 10
Z9 12
U1 0
U2 6
PU GESELLSCHAFT SCHWEIZER TIERARZTINNEN & TIERARZTE
PI BERN
PA BRUCKFELDSTRASSE 18, BERN, CH-3012, SWITZERLAND
SN 0036-7281
EI 1664-2848
J9 SCHWEIZ ARCH TIERH
JI Schweiz. Arch. Tierheilkd.
PD FEB
PY 2015
VL 157
IS 2
BP 105
EP 109
DI 10.17236/sat00009
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CC0GQ
UT WOS:000350014200011
PM 26753336
DA 2026-07-24
ER
PT J
AU Davis, JS
   Kourliouros, A
   Deshpande, R
   Cavale, N
AF Davis, James S.
   Kourliouros, Antonios
   Deshpande, Ranjit
   Cavale, Naveen
TI Novel technique for avoidance of pressure competition between a negative
   pressure wound therapy device and chest drains in the management of deep
   sternal wound infections
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy device; Sternal wound infection; Pleural
   effusion; Mediastinitis
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS
AB In recent years, the use of negative pressure wound therapy (NPWT) devices has changed the way sternal wound infections are being managed. It is not uncommon for deep sternal wound infections to occur together with mediastinal or even pleural collections requiring underwater seal drainage. In these patients in whom there is a communication between the pleural and mediastinal cavities, the concomitant use of an NPWT device negates the pressure gradient within the pleural and mediastinal drains, allowing suppurative fluid to stagnate. We present a novel technique to address this limitation of NPWT devices in patients with sternal wound infections that communicate with a pleural collection.
C1 [Davis, James S.; Cavale, Naveen] Kings Coll Hosp London, Dept Plast Surg, London SE5 9RS, England.
   [Kourliouros, Antonios; Deshpande, Ranjit] Kings Coll Hosp London, Dept Cardiothorac Surg, London SE5 9RS, England.
C3 King's College Hospital NHS Foundation Trust; King's College Hospital;
   King's College Hospital NHS Foundation Trust; King's College Hospital
RP Davis, JS (通讯作者)，Kings Coll Hosp London, Dept Plast Surg, Denmark Hill, London SE5 9RS, England.
EM jamesdavis1@nhs.net
RI Cavale, Naveen/KHX-8083-2024
CR Ennker IC, 2009, J PLAST RECONSTR AES, V62, P1479, DOI 10.1016/j.bjps.2008.05.017
   Falagas ME, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064741
   Ortak T, 2008, EUR J PLAST SURG, V30, P223, DOI 10.1007/s00238-007-0194-y
   Ridderstolpe L, 2001, EUR J CARDIO-THORAC, V20, P1168, DOI 10.1016/S1010-7940(01)00991-5
   Scholl L, 2004, J CARDIAC SURG, V19, P453, DOI 10.1111/j.0886-0440.2004.05002.x
   Schols RM, 2011, EUR J PLAST SURG, V34, P487, DOI 10.1007/s00238-011-0573-2
   Vos RJ, 2012, INTERACT CARDIOV TH, V14, P17, DOI 10.1093/icvts/ivr049
   Yu AW, 2013, INTERACT CARDIOV TH, V17, P861, DOI 10.1093/icvts/ivt326
NR 8
TC 3
Z9 5
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD FEB
PY 2015
VL 20
IS 2
BP 270
EP 272
DI 10.1093/icvts/ivu389
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA CC2UG
UT WOS:000350199500022
PM 25415315
OA Bronze
DA 2026-07-24
ER
PT J
AU Nguyen, TQ
   Franczyk, M
   Lee, JC
   Greives, MR
   O'Connor, A
   Gottlieb, LJ
AF Nguyen, Trang Q.
   Franczyk, Mieczyslawa
   Lee, Justine C.
   Greives, Matthew R.
   O'Connor, Annemarie
   Gottlieb, Lawrence J.
TI Prospective Randomized Controlled Trial Comparing Two Methods of
   Securing Skin Grafts Using Negative Pressure Wound Therapy:
   Vacuum-Assisted Closure and Gauze Suction
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID DEVICE; BOLSTER
AB Negative pressure wound therapy (NPWT) has revolutionized the management of complicated wounds and has contributed an additional modality for securing split thickness skin grafts (STSG). The standard for NPWT is the vacuum-assisted closure (VAC) device. The authors' institution has accumulated experience using standard gauze sealed with an occlusive dressing and wall suction (GSUC) as their primary mode for NPWT. The authors report a randomized controlled trial comparing the efficacy of the GSUC vs the VAC in securing STSG. A prospective, randomized, controlled trial was conducted in 157 wounds in 104 patients requiring STSG from August 2009 to July 2012. All wounds were randomized to VAC or GSUC treatment and assessed for skin graft adherence/take. At postoperative day 4 or 5, NPWT was discontinued, and the size of the graft and any nonadherent areas were measured and recorded. Concomitant comorbidities, wound location, etiology, study failures, and reoperative rates were also reviewed. In all, 77 and 80 wounds were randomized to the GSUC and VAC study arms. Patient demographics were similar between both groups in terms of age, sex, comorbidities, etiology, and wound location. In all, 64 of 80 wounds in the GSUC group and 60 of 77 wounds in the VAC group had full take of the skin graft by postoperative day 4 or 5 (P = .80). The mean percent take in the GSUC group was 96.12% vs 96.21% in the VAC arm (P = .98). The use of NPWT in securing STSG is a useful method to promote adherence and healing. This study demonstrates that a low-cost, readily accessible system utilizing gauze dressings and wall suction (GSUC) results in comparable skin graft take in comparison to the VAC device.
C1 [Nguyen, Trang Q.; Greives, Matthew R.; O'Connor, Annemarie; Gottlieb, Lawrence J.] Univ Chicago Med, Sect Plast & Reconstruct Surg, Dept Surg, Chicago, IL USA.
   [Franczyk, Mieczyslawa] Univ Chicago Med, Dept Therapy Serv, Chicago, IL USA.
   [Lee, Justine C.] Univ Calif Los Angeles, David Geffen Sch Med, Div Plast & Reconstruct Surg, Los Angeles, CA 90095 USA.
C3 University of Chicago; University of Chicago; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center; David Geffen School of Medicine at UCLA
RP Gottlieb, LJ (通讯作者)，Univ Chicago, Dept Surg, 5841 South Maryland Ave,MC 6035, Chicago, IL 60637 USA.
OI Lee, Justine C/0000-0002-8943-0837; Greives, Matthew/0000-0003-4602-5054
FU Barbara White Gift Fund
FX This study was supported by the Dean and Barbara White Gift Fund.
CR Andrews BT, 2006, LARYNGOSCOPE, V116, P1918, DOI 10.1097/01.mlg.0000235935.07261.98
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   Körber A, 2008, DERMATOLOGY, V216, P250, DOI 10.1159/000112937
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
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   Weinfeld AB, 2005, ANN PLAS SURG, V54, P178, DOI 10.1097/01.sap.0000143606.39693.3f
NR 16
TC 24
Z9 30
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2015
VL 36
IS 2
BP 324
EP 328
DI 10.1097/BCR.0000000000000089
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA CC5JO
UT WOS:000350395100029
PM 25162948
DA 2026-07-24
ER
PT J
AU Arul, GS
   Sonka, BJ
   Lundy, JB
   Rickard, RF
   Jeffery, SLA
AF Arul, G. Suren
   Sonka, B. J.
   Lundy, J. B.
   Rickard, R. F.
   Jeffery, S. L. A.
TI Management of complex abdominal wall defects associated with penetrating
   abdominal trauma
SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PLANNED VENTRAL HERNIA; DAMAGE CONTROL; STAGED
   MANAGEMENT; NEGATIVE-PRESSURE; WOUND CLOSURE; LAPAROTOMY; ABDOMEN
AB Introduction The paradigm of Damage Control Surgery (DCS) has radically improved the management of abdominal trauma, but less well described are the options for managing the abdominal wall itself in an austere environment. This article describes a series of patients with complex abdominal wall problems managed at the UK-led Role 3 Medical Treatment Facility (MTF) in Camp Bastion, Afghanistan.
   Method Contemporaneous review of a series of patients with complex abdominal wall injuries who presented to the Role 3 MTF between July and November 2012.
   Results Five patients with penetrating abdominal trauma associated with significant damage to the abdominal wall were included. All patients were managed using DCS principles, leaving the abdominal wall open at the end of the first procedure. Subsequent management of the abdominal wall was determined by a multidisciplinary team of general and plastic surgeons, intensivists and specialist nurses. The principles of management identified included minimising tissue loss on initial laparotomy by joining adjacent wounds and marginal debridement of dead tissue; contraction of the abdominal wall was minimised by using topical negative pressure dressing and dermal-holding sutures. Definitive closure was timed to allow oedema to settle and sepsis to be controlled. Closure techniques include delayed primary closure with traction sutures, components separation, and mesh closure with skin grafting.
   Discussion A daily multidisciplinary team discussion was invaluable for optimal decision making regarding the most appropriate means of abdominal closure. Dermal-holding sutures were particularly useful in preventing myostatic contraction of the abdominal wall. A simple flow chart was developed to aid decision making in these patients. This flow chart may prove especially useful in a resource-limited environment in which returning months or years later for closure of a large ventral hernia may not be possible.
C1 [Arul, G. Suren] 212 Field Hosp, Sheffield, S Yorkshire, England.
   [Sonka, B. J.] William Beaumont Army Med Ctr, Dept Surg, El Paso, TX 79920 USA.
   [Lundy, J. B.] Joint Base Sane Antonio, San Antonio Mil Med Ctr, San Antonio, TX USA.
   [Rickard, R. F.; Jeffery, S. L. A.] Royal Ctr Def Med, Dept Surg, Birmingham, W Midlands, England.
   [Rickard, R. F.] Derriford Hosp, Plymouth PL6 8DH, Devon, England.
C3 William Beaumont Army Medical Center; Brooke Army Medical Center; Royal
   Centre for Defence Medicine; Derriford Hospital
RP Arul, GS (通讯作者)，Birmingham Childrens Hosp, Dept Surg, Steelhouse Lane, Birmingham B4 6NH, W Midlands, England.
EM surenarul@doctors.org.uk
RI ; jeffery, steven/A-5207-2013
OI Arul, Gularaj Suren/0000-0002-1586-6857; jeffery,
   steven/0000-0001-6587-5412
CR [Anonymous], J TRAUMA
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NR 30
TC 5
Z9 6
U1 0
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0035-8665
EI 2052-0468
J9 J ROY ARMY MED CORPS
JI J. R. Army Med. Corps
PD MAR
PY 2015
VL 161
IS 1
BP 46
EP 52
DI 10.1136/jramc-2014-000276
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CC7VB
UT WOS:000350575400011
PM 24817321
DA 2026-07-24
ER
PT J
AU Pandit, V
   Nesbitt, SR
   Kim, DY
   Mixon, A
   Kotha, SP
AF Pandit, Vaibhav
   Nesbitt, Sterling Robert
   Kim, Diana Y.
   Mixon, Amanda
   Kotha, Shiva P.
TI Combinatorial therapy using negative pressure and varying lithium dosage
   for accelerated wound healing
SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
LA English
DT Article
DE Wnt signaling; Piezoelectric vacuum pump; Murine fibroblasts;
   beta-catenin; Migration into score
ID BETA-CATENIN; SIZE
AB In this work, we investigated the effects of negative pressure, applied using a pump designed for Negative Pressure Wound Therapy (NPWT), on the process of wound healing in vitro via initiation of the Wnt signaling pathway. Results indicate that negative pressure enhanced Wnt signaling and migration into a simulated wound in vitro in NIH-3T3 murine fibroblast cells. Increasing doses of lithium (upto 15 mM) increased basal Wnt signaling and enhanced cell migration into the simulated wound site. A combination of negative pressure and increased doses of lithium synergistically increased Wnt signaling and demonstrated further enhanced cell migration into simulated wound sites, with maximal filling of the simulated wound observed at lithium concentrations of at least 10 mM. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Pandit, Vaibhav; Nesbitt, Sterling Robert; Kim, Diana Y.; Mixon, Amanda; Kotha, Shiva P.] Rensselaer Polytech Inst, Dept Biomed Engn, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA.
C3 Rensselaer Polytechnic Institute
RP Pandit, V (通讯作者)，Rensselaer Polytech Inst, Dept Biomed Engn, Ctr Biotechnol & Interdisciplinary Studies, 110 8th St, Troy, NY 12180 USA.
EM pandiv@rpi.edu; sterling.nesbitt@gmail.com; kimd13@rpi.edu;
   mixona@rpi.edu; kothas2@rpi.edu
FU NY Capital Alliance Program; Rensselaer; NIH/NIA [R01 AG030637]
FX We would like to acknowledge funding provided by the NY Capital Alliance
   Program and start-up funding from Rensselaer. We would also like to
   acknowledge NIH/NIA R01 AG030637.
CR Amini-Nik S, 2014, J CLIN INVEST, V124, P2599, DOI 10.1172/JCI62059
   Amini-Nik S, 2011, STEM CELLS, V29, P1371, DOI 10.1002/stem.688
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NR 14
TC 14
Z9 16
U1 0
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1751-6161
EI 1878-0180
J9 J MECH BEHAV BIOMED
JI J. Mech. Behav. Biomed. Mater.
PD APR
PY 2015
VL 44
BP 173
EP 178
DI 10.1016/j.jmbbm.2015.01.012
PG 6
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA CD1LK
UT WOS:000350836200018
PM 25658877
DA 2026-07-24
ER
PT J
AU Saziye, K
   Afksendiyos, K
AF Saziye, Karaca
   Afksendiyos, Kalangos
TI The vacuum-assisted closure (VAC®) system for surgical site infection
   with involved vascular grafts
SO VASCULAR
LA English
DT Article
DE SSI; vascular graft infection; VAC; wound infection
ID RESISTANT STAPHYLOCOCCUS-AUREUS; TERM-FOLLOW-UP; NEGATIVE-PRESSURE;
   MANAGEMENT; GROIN; SURGERY; EXPERIENCE; THERAPY; IMPACT
AB Background: In vascular surgery, surgical site infection is the most common postoperative morbidity, occurring in 5-10% of vascular patients. The optimal management of surgical site infection with involved lower limb vascular grafts remains controversial. We present our 6-year results of using the V.A.C.((R)) system in surgical site infection with involved vascular grafts.
   Methods: A retrospective 6-year review of patient who underwent a VAC((R)) therapy for postoperative surgical site infection in lower limb with involved vascular grafts in our department between January 2006 and December 2011. V. A. C therapy was used in 40 patients. All patients underwent surgical wound revision with VAC((R)) therapy and antibiotics.
   Results: The mean time of use of the V. A. C. system was 14.2 days. After mean of 12 days in 34 of 40 patients, in whom the use of VAC((R)) therapy resulted in delayed primary closure or healing by secondary intention. The mean postoperative follow-up time was 61.67 months, during which 3 patients died.
   Conclusion: We showed that the V.A.C.((R)) system is valuable for managing specifically surgical site infection with involved vascular grafts. Using the V.A.C.((R)) system, reoperation rates are reduced; 85% of patients avoided graft replacement.
C1 [Saziye, Karaca; Afksendiyos, Kalangos] Univ Hosp Geneva, Dept Cardiovasc Surg, CH-1211 Geneva 14, Switzerland.
C3 University of Geneva
RP Saziye, K (通讯作者)，Univ Hosp Geneva, Dept Cardiovasc Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM saziye.karaca@hcuge.ch
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NR 28
TC 8
Z9 9
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD APR
PY 2015
VL 23
IS 2
BP 144
EP 150
DI 10.1177/1708538114537488
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CD3EP
UT WOS:000350961000006
PM 24879657
DA 2026-07-24
ER
PT J
AU Indolfi, C
   Passafaro, F
   Mongiardo, A
   Spaccarotella, C
   Torella, D
   Sorrentino, S
   Polimeni, A
   Emanuele, V
   Curcio, A
   De Rosa, S
AF Indolfi, Ciro
   Passafaro, Francesco
   Mongiardo, Annalisa
   Spaccarotella, Carmen
   Torella, Daniele
   Sorrentino, Sabato
   Polimeni, Alberto
   Emanuele, Vittorio
   Curcio, Antonio
   De Rosa, Salvatore
TI Delayed Sudden Radial Artery Rupture After Left Transradial Coronary
   Catheterization A Case Report
SO MEDICINE
LA English
DT Article
AB Local complications at the radial access site are not frequent, hence its large diffusion as the preferred access route for endovascular procedures. However, in a time of fast widespreading, better comprehension of all potential complications becomes critical to facilitate their early recognition and the most appropriate treatment.
   In this case report, we present for the first time a case of sudden massive bleeding at the left wrist, due to spontaneous gross rupture of the left radial artery bleeding 15 days after an endovascular procedure through a left radial arterial access. The patient had been readmitted to the hospital after evidence of local infection at the left wrist with loss of substance. The radial artery was patent with no evidence of pseudoaneurysm.
   After sudden radial artery rupture, with massive bleeding and suspicion that the local infection could have reached the arterial wall, surgical hemostasis with artery ligation was obtained. Healing of the large wound was then efficiently speeded up using a negative pressure wound therapy.
   This is the first case of macroscopic radial artery rupture associated with local wrist infection after arterial catheterization. After prompt surgical hemostasis, negative pressure wound therapy was very helpful in favoring healing of the large and deep wound.
C1 [Indolfi, Ciro; Passafaro, Francesco; Mongiardo, Annalisa; Spaccarotella, Carmen; Torella, Daniele; Sorrentino, Sabato; Polimeni, Alberto; Emanuele, Vittorio; Curcio, Antonio; De Rosa, Salvatore] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Div Cardiol, I-88100 Catanzaro, Italy.
   [Indolfi, Ciro] CNR, Dept Med, URT CNR, Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Consiglio Nazionale delle
   Ricerche (CNR)
RP Indolfi, C (通讯作者)，Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, I-88100 Catanzaro, Italy.
EM indolfi@unicz.it
RI Sorrentino, Sabato/D-3297-2019; De Rosa, Salvatore/J-6350-2012;
   Spaccarotella, CARMEN ANNA MARIA/IAS-0433-2023; Polimeni,
   Alberto/M-9243-2019; Curcio, Antonio/JZT-5160-2024; TORELLA,
   Daniele/A-3296-2009
OI Sorrentino, Sabato/0000-0002-8316-7134; De Rosa,
   Salvatore/0000-0001-5388-942X; Spaccarotella, CARMEN ANNA
   MARIA/0000-0003-1825-0510; Mongiardo, Annalisa/0009-0001-5364-7479;
   Polimeni, Alberto/0000-0002-9166-3031; Curcio,
   Antonio/0000-0003-3213-4436; TORELLA, Daniele/0000-0002-4915-5084;
   INDOLFI, Ciro/0000-0003-1241-6487
CR Basili S, 2014, CIRC-CARDIOVASC INTE, V7, P577, DOI 10.1161/CIRCINTERVENTIONS.113.001197
   Dandekar VK, 2012, CARDIOVASC REVASCULA, V13, P39, DOI 10.1016/j.carrev.2011.08.005
   De Rosa S, 2014, JACC-CARDIOVASC INTE, V7, pE89, DOI 10.1016/j.jcin.2013.11.028
   De Rosa S, 2014, INT J CARDIOL, V171, P66, DOI 10.1016/j.ijcard.2013.11.046
   Hamon M, 2013, EUROINTERVENTION, V8, P1242, DOI 10.4244/EIJV8I11A192
   Lehmann R, 2011, J INTERV CARDIOL, V24, P56, DOI 10.1111/j.1540-8183.2010.00603.x
   Nagelschmitz J, 2014, CLIN PHARMACOL-ADV A, V6, P51, DOI 10.2147/CPAA.S47895
   Pignatelli P, 2011, CARDIOVASC THER, V29, P385, DOI 10.1111/j.1755-5922.2010.00168.x
   Xhepa E, 2014, EUROINTERVENTION, V10, P198, DOI 10.4244/EIJV10I2A33
NR 9
TC 4
Z9 4
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAR
PY 2015
VL 94
IS 10
AR e634
DI 10.1097/MD.0000000000000634
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CD3SP
UT WOS:000351001300022
PM 25761194
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Cunningham, T
   Marks, M
AF Cunningham, Teresa
   Marks, Malcolm
TI Vacuum-Assisted Closure Device and Skin Substitutes for Complex Mohs
   Defects
SO DERMATOLOGIC SURGERY
LA English
DT Article
ID ARTIFICIAL SKIN; PRESSURE; MANAGEMENT; DRESSINGS; THERAPY; INTEGRA;
   GRAFTS; TRIAL
AB BACKGROUND Soft tissue defects created by excision of dermatologic malignancies may present a significant challenge to the reconstructive surgeon, particularly when tendon, bone, cartilage, or other vital structures are exposed. Although there are several reliable options for regional or free tissue transfer, many patients with skin cancers are poor surgical candidates. Recent literature has described the use of an acellular dermal regeneration template (ADRT) (Integra LifeSciences Corp, Plainsboro, NJ) with split-thickness skin grafting (STSG) as an alternative to the previously mentioned surgical options.
   OBJECTIVE To use ADRT with negative-pressure wound therapy (NPWT) and STSG to reconstruct complex Mohs defects of the scalp and feet.
   MATERIALS AND METHODS Two patients underwent wide local excision of squamous cell carcinomas of the skin. ADRT and a NPWT device were applied. The patients were then skin grafted 7 to 10 days later.
   RESULTS Both patients had take of their skin grafts and completely healed their wounds without local recurrence. Results were both functionally and aesthetically satisfactory.
   CONCLUSION The use of ADRT with vacuum-assisted closure followed by split-thickness skin grafting is an acceptable alternative to regional or free tissue transfer for reconstruction of complex Mohs defects.
C1 [Cunningham, Teresa; Marks, Malcolm] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Cunningham, T (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM tcunning@wakehealth.edu
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NR 17
TC 22
Z9 23
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-0512
EI 1524-4725
J9 DERMATOL SURG
JI Dermatol. Surg.
PD SEP
PY 2014
VL 40
IS 9
SU S
BP S120
EP S126
DI 10.1097/DSS.0000000000000113
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CD4MP
UT WOS:000351057400013
PM 25158872
DA 2026-07-24
ER
PT J
AU Atema, JJ
   Gans, SL
   Boermeester, MA
AF Atema, J. J.
   Gans, S. L.
   Boermeester, M. A.
TI Systematic Review and Meta-analysis of the Open Abdomen and Temporary
   Abdominal Closure Techniques in Non-trauma Patients
SO WORLD JOURNAL OF SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; MEDIATED FASCIAL
   TRACTION; DAMAGE CONTROL SURGERY; OPEN MANAGEMENT; WOUND CLOSURE;
   PLANNED REOPERATIONS; COMPARTMENT SYNDROME; SEVERE PERITONITIS; SEPTIC
   ABDOMEN
AB Several challenging clinical situations in patients with peritonitis can result in an open abdomen (OA) and subsequent temporary abdominal closure (TAC). Indications and treatment choices differ among surgeons. The risk of fistula development and the possibility to achieve delayed fascial closure differ between techniques. The aim of this study was to review the literature on the OA and TAC in peritonitis patients, to analyze indications and to assess delayed fascial closure, enteroatmospheric fistula and mortality rate, overall and per TAC technique.
   Electronic databases were searched for studies describing the OA in patients of whom 50 % or more had peritonitis of a non-traumatic origin.
   The search identified 74 studies describing 78 patient series, comprising 4,358 patients of which 3,461 (79 %) had peritonitis. The overall quality of the included studies was low and the indications for open abdominal management differed considerably. Negative pressure wound therapy (NPWT) was the most frequent described TAC technique (38 of 78 series). The highest weighted fascial closure rate was found in series describing NPWT with continuous mesh or suture mediated fascial traction (6 series, 463 patients: 73.1 %, 95 % confidence interval 63.3-81.0 %) and dynamic retention sutures (5 series, 77 patients: 73.6 %, 51.1-88.1 %). Weighted rates of fistula varied from 5.7 % after NPWT with fascial traction (2.2-14.1 %), 14.6 % (12.1-17.6 %) for NPWT only, and 17.2 % after mesh inlay (17.2-29.5 %).
   Although the best results in terms of achieving delayed fascial closure and risk of enteroatmospheric fistula were shown for NPWT with continuous fascial traction, the overall quality of the available evidence was poor, and uniform recommendations cannot be made.
C1 [Atema, J. J.; Gans, S. L.; Boermeester, M. A.] Univ Amsterdam, Acad Med Ctr, Dept Surg G4 142, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam
RP Atema, JJ (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Surg G4 142, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM j.j.atema@amc.uva.nl
OI Boermeester, Marja/0000-0003-3890-8105
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NR 87
TC 181
Z9 216
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD APR
PY 2015
VL 39
IS 4
BP 912
EP 925
DI 10.1007/s00268-014-2883-6
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CD6WN
UT WOS:000351231100014
PM 25446477
OA Green Accepted
DA 2026-07-24
ER
PT J
AU McCallon, SK
   Frilot, C
AF McCallon, Stanley K.
   Frilot, Clifton
TI A Retrospective Study of the Effects of Clostridial Collagenase Ointment
   and Negative Pressure Wound Therapy for the Treatment of Chronic
   Pressure Ulcers
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE retrospective study; wound care; chronic pressure ulcer; collagenase;
   negative pressure wound therapy; debridement
ID VACUUM-ASSISTED CLOSURE; BED PREPARATION; DEBRIDEMENT; TRIAL
AB Nonhealing, chronic pressure ulcers present a continuous challenge in the global health care venue, with decreased mobility and the effects of aging on skin placing the elderly at particular risk. Debridement is an important process to decrease risk of infection and promote healing. Enzymatic debridement with, for example, clostridial collagenase ointment (CCO) has been shown to assist with the achievement and maintenance of a clean wound bed in preparation for closure. Negative pressure wound therapy (NPWT) has also been used successfully for the treatment of wounds. Although conclusive research has demonstrated positive independent effects of both CCO and NPWT as treatments for chronic pressure ulcers, there are no known published studies that have investigated the 2 as a conjunctive treatment. Materials and Methods. A retrospective analysis of 114 adult patients was conducted to assess wound healing of chronic pressure ulcers in a setting with medically complex patients. Two groups were established comparing those who received NPWT alone to those who received NPWT plus CCO. The study sample included 67 patients treated with NPWT + CCO and 47 patients who received only NPWT. Results. Results were similar for both treatment groups with mean values indicating the cohorts were closely aligned with respect to wound size, complexity, length of long-term acute care hospital stay, and duration of NPWT. The patients who received NPWT + CCO demonstrated statistically significant changes in several key areas including initial Bates-Jensen Wound Assessment Tool (BWAT) score, changes in the overall BWAT score and in the necrotic tissue domain. Conclusion. Data analysis from this retrospective study indicates patients who received both therapies (NPWT + CCO) demonstrated improved outcomes in speed of debridement and rate of wound closure compared to those who received NPWT alone.
C1 [McCallon, Stanley K.; Frilot, Clifton] LSU Hlth Sci Ctr Shreveport, Shreveport, LA 71103 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport
RP McCallon, SK (通讯作者)，LSU Hlth Sci Ctr Shreveport, Shreveport, LA 71103 USA.
EM smccal@lsuhsc.edu
FU Smith and Nephew Biotherapeutics, Fort Worth, TX
FX This study was funded in part through an unrestricted grant from Smith
   and Nephew Biotherapeutics, Fort Worth, TX. The grantor had no input on
   study design, data collection, or statistical analysis.
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NR 28
TC 13
Z9 17
U1 0
U2 12
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2015
VL 27
IS 3
BP 44
EP 53
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CD7UA
UT WOS:000351297600002
PM 25786076
DA 2026-07-24
ER
PT J
AU Law, A
   Cyhaniuk, A
   Krebs, B
AF Law, Amy
   Cyhaniuk, Anissa
   Krebs, Blake
TI Comparison of Health Care Costs and Hospital Readmission Rates
   Associated With Negative Pressure Wound Therapies
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; cost effective; comparative
   effectiveness; chronic wounds
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; RANDOMIZED-TRIAL;
   PREVALENCE; IMPACT
AB Objective. A retrospective national claims database analysis evaluated total and wound-related costs (eg, hospital readmission rates) for patients with chronic wounds treated with negative pressure wound therapy (NPWT), comparing NPWT-V (V.A.C. Therapy, KCI, an Acelity company, San Antonio, TX) and NPWT-O (other non-KCI models of NPWT, the brands of which were not known to the researchers). Methods. Patients with >= 1 NPWT claim from January 2009-June 2012 in outpatient settings in the United States were included, if they had continuous medical and pharmacy benefits for 12 months before the initial index date of their NPWT claim and at least 3 months post index. Mean total health care costs were assessed at 3 months and 12 months; wound-related hospital readmission rates were assessed at 3 months and 6 months. Cost differences between cohorts were analyzed by t test and readmission rates were analyzed by chi-square test. Results. At 3 months, the cohort of NPWT-V patients was significantly younger (59.2 vs 63.6 years, P < 0.01). The same patients were followed at 3, 6, and 12 months, although some fell out as time progressed. At the 3-month assessment, mean comorbidity scores did not differ between the NPWT-V group and the NPWT-O groups (3.38 vs 3.66). Total costs were lower for NPWT-V vs NPWT-O at 3 months ($35,498 vs $39,722, respectively; P = 0.08) and 12 months ($80,768 vs $111,212; P = 0.03). Significantly lower inpatient (P = 0.01), emergency room (P < 0.01), and home (P = 0.05) costs, despite higher (P = 0.04) NPWT costs, accounted for lower 12-month NPWT-V total costs. Wound-related readmission rates were significantly lower for NPWT-V at 3 months (5% vs 8%; P <= 0.01) and 6 months (6% vs 11%; P = 0.01). For all wound types, NPWT-O patients had a 17-fold higher rate of switching to alternate NPWT models compared with NPWT-V patients. Conclusion. In this retrospective analysis, NPWT-V patients had lower total costs, lower wound-related costs, and lower hospital readmission rates than NPWT-O patients at all time points assessed.
C1 [Law, Amy] Acelity Co, KCI, San Antonio, TX 78249 USA.
   [Cyhaniuk, Anissa; Krebs, Blake] Optum Life Sci, Eden Prairie, MN USA.
C3 Optum
RP Law, A (通讯作者)，Acelity Co, KCI, 12930 Interstate Highway 10 West, San Antonio, TX 78249 USA.
EM amy.law@acelity.com
FU Optum Life Sciences (Eden Prairie, MN)
FX The authors disclose that Amy Law is an employee of KCI, an Acelity
   Company (San Antonio, TX); Anissa Cyhaniuk and Blake Krebs, with Optum
   Life Sciences (Eden Prairie, MN), were paid consultants on this study.
   Claims data and analytics were provided by Optum Life Sciences.
CR [Anonymous], 3 C WORLD UN WOUND H
   [Anonymous], CONGR BUDG OFF PUB
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NR 28
TC 6
Z9 6
U1 0
U2 12
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2015
VL 27
IS 3
BP 63
EP 72
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CD7UA
UT WOS:000351297600004
PM 25786078
DA 2026-07-24
ER
PT J
AU Hermans, MHE
   Lee, SK
   Ragan, MR
   Laudi, P
AF Hermans, Michel H. E.
   Lee, S. Kwon
   Ragan, Mitzie R.
   Laudi, Pam
TI Results of a Retrospective Comparative Study: Material Cost for Managing
   a Series of Large Wounds in Subjects With Serious Morbidity With a
   Hydrokinetic Fiber Dressing or Negative Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; hydrokinetic fiber dressing; chronic
   wounds
ID LOW-FREQUENCY ULTRASOUND; NONCONTACT; MIST; CARE; SKIN
AB This retrospective observational study analyzed lesions with regard to healing trends and cost of materials. Materials and Methods. The observed lesions were mostly postsurgical or stage IV pressure ulcers in patients with serious morbidity. The wounds were treated with a hydrokinetic fiber dressing (sorbion Sachet S, sorbion Gmbh & Co, a BSN medical company, Senden, Germany) (n = 26) or negative pressure wound therapy (NPWT) (n = 16). Results. Primary healing trends (ie, reduction of wound size, change from necrosis to granulation tissue, and change from granulation tissue to epithelium) and secondary healing trends (ie, periwound conditions) were similar for wounds treated with the hydrokinetic dressing when compared to wounds treated with NPWT. Cost of materials was substantially lower for wounds treated with the hydrokinetic fiber dressing compared to the NPWT, with cost reductions of $1,640 (348%) to $2,242 (1794%) per wound, depending on the criteria used for the analysis. Conclusion. In this set of wounds, the hydrokinetic fiber dressing was shown to lead to similar healing results while providing substantial reductions of the cost of materials. For the types of wounds presented in this observational study, the hydrokinetic fiber dressing seems to be an effective substitution for negative pressure wound therapy.
C1 [Hermans, Michel H. E.] Hermans Consulting Inc, Newtown, PA 18940 USA.
   [Lee, S. Kwon; Ragan, Mitzie R.; Laudi, Pam] Vibra Hosp Sacramento, Folsom, CA USA.
RP Hermans, MHE (通讯作者)，Hermans Consulting Inc, Newtown, PA 18940 USA.
EM mhermans@hermans-hci.com
FU sorbion Gmbh & Co, a BSN medical company (Selden, Germany)
FX This study was supported by sorbion Gmbh & Co, a BSN medical company
   (Selden, Germany), for which Michel H. E. Hermans, MD, and Kwon Lee, MD,
   FACS, FAPWH, are consultants.
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NR 30
TC 4
Z9 6
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2015
VL 27
IS 3
BP 73
EP 82
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CD7UA
UT WOS:000351297600005
PM 25786079
DA 2026-07-24
ER
PT J
AU Or, M
   Van Goethem, B
   Polis, I
   Spillebeen, A
   Vandekerckhove, P
   Saunders, J
   de Rooster, H
AF Or, M.
   Van Goethem, B.
   Polis, I.
   Spillebeen, A.
   Vandekerckhove, P.
   Saunders, J.
   de Rooster, H.
TI Pedicle digital pad transfer and negative pressure wound therapy for
   reconstruction of the weight-bearing surface after complete digital loss
   in a dog
SO VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
LA English
DT Article
DE Digit amputation; digital pad transfer; NPVVT; negative pressure wound
   therapy; wound; healing
ID VACUUM-ASSISTED-CLOSURE; DISTAL EXTREMITY; SKIN-GRAFT; MANAGEMENT;
   SALVAGE; AMPUTATION
AB A young Labrador Retriever was presented for treatment of severe distal hindlimb necrosis caused by bandage ischemia. During digit amputation at the metatarsophalangeal joints, the third and fourth digital pads were salvaged and transferred to the metatarsal stump to create a weight-bearing surface. Negative pressure wound therapy (NPVVT) was utilized for flap immobilization and to promote granulation tissue in the remaining wound defect. Sturdy adherence of the digital pads was achieved after only four days. The skin defect healed completely by second intention and the stump was epithelialized with a thin pad after three months. At the nine month follow-up examination, the stump had a thick hyperkeratinized pad. The dog walked and ran without any apparent signs of discomfort and compensated for the loss of limb length by extending the stifle and tarsocrural joints. Despite a challenging wound in a difficult anatomical location, digital pad flap transfer and NPWT proved successful in restoring long-term ambulation in an active large breed dog.
C1 [Or, M.; Van Goethem, B.; Polis, I.; Spillebeen, A.; de Rooster, H.] Univ Ghent, Fac Vet Med, Dept Small Anim Med & Clin Biol, B-9820 Merelbeke, Belgium.
   [Vandekerckhove, P.] DAC Malpertuus, Heusden, Belgium.
   [Saunders, J.] Univ Ghent, Fac Vet Med, Dept Med Imaging Domest Anim & Small Anim Orthope, B-9820 Merelbeke, Belgium.
C3 Ghent University; Ghent University
RP Or, M (通讯作者)，Univ Ghent, Fac Vet Med, Dept Small Anim Med & Clin Biol, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM matanor5@gmail.com
RI ; de Rooster, Hilde/AAX-9497-2020; Van Goethem, Bart/AAM-7175-2020
OI Spillebeen, Anneleen Lily/0009-0006-7012-9821; de Rooster,
   Hilde/0000-0001-8087-256X; 
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NR 34
TC 7
Z9 8
U1 0
U2 19
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0932-0814
EI 2567-6911
J9 VET COMP ORTHOPAED
JI Vet. Comp. Orthop. Traumatol.
PY 2015
VL 28
IS 2
BP 140
EP 144
DI 10.3415/VCOT-14-04-0056
PG 5
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA CD8HF
UT WOS:000351335100010
PM 25449188
DA 2026-07-24
ER
PT J
AU Banasiewicz, T
   Hermann, J
   Krokowicz, L
   Drews, M
AF Banasiewicz, T.
   Hermann, J.
   Krokowicz, L.
   Drews, M.
TI "Sandwich technique" with bridging, a modification of negative pressure
   wound therapy for anal fistulas
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
C1 [Banasiewicz, T.; Hermann, J.; Krokowicz, L.; Drews, M.] Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, PL-60355 Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Krokowicz, L (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, Przybyszewskiego 49, PL-60355 Poznan, Poland.
EM lkrokowicz@gmail.com
CR [Anonymous], 2014, NPWT
   Banasiewicz T., 2014, Negative Pressure Wound Therapy, V1, P39
   Bemelman WA, 2009, TECH COLOPROCTOL, V13, P261, DOI 10.1007/s10151-009-0543-x
   Horst N, 2014, NPWT, V1, P17
NR 4
TC 6
Z9 8
U1 0
U2 1
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD MAR
PY 2015
VL 19
IS 3
BP 173
EP 175
DI 10.1007/s10151-014-1247-4
PG 3
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA CE0VL
UT WOS:000351526700008
PM 25403770
DA 2026-07-24
ER
PT J
AU Spindler, N
   Lehmann, S
   Steinau, HU
   Mohr, FW
   Langer, S
AF Spindler, N.
   Lehmann, S.
   Steinau, H. -U.
   Mohr, F. -W.
   Langer, S.
TI Complication management after interventions on thoracic organs. Deep
   sternal wound infections
SO CHIRURG
LA German
DT Article
DE Median sternotomy; Sternal osteomyelitis; Mediastinitis; Wound
   debridement; Muscle flaps
ID VACUUM-ASSISTED CLOSURE; SURGERY; MEDIASTINITIS
AB With an incidence rate of 0.5-4 % and a mortality of up to 50 %, deep sternal wound infections are a rare but devastating complication after median sternotomy for cardiac surgery. Currently, no standard operating procedures exist. Long-term drainage with continuous lavage or negative pressure wound therapy should be used to condition the wound. After restabilization of the sternum and primary closure, the infection often reoccurs presenting deep cavities with an open, unstable thorax and an uncovered mediastinum. This article gives an overview of the different options for deep sternal wound infections in plastic reconstructive surgery. The key point for successful treatment is still the extent of debridement. Primary coverage with a pedicled flap can be made only if the wound debridement was performed radically enough. In the clinic of the author, in which over 120 patients with deep sternal wound infections were treated in 2.5 years, latissimus dorsi muscle flaps have been established as the gold standard.
C1 [Spindler, N.; Langer, S.] Univ Klin Orthopadie Unfallchirurg & Plast Chirur, Abt Plast Asthet & Spezielle Handchirurg, D-04103 Leipzig, Germany.
   [Lehmann, S.; Mohr, F. -W.] Univ Klin Leipzig, Herzzentrum Leipzig GmbH, Helios Klin, Leipzig, Germany.
   [Steinau, H. -U.] Univ Klinikum Essen, Klin Unfallchirurg, Essen, Germany.
C3 Helios Kliniken; Heart Center Leipzig GMBH; Leipzig University;
   University of Duisburg Essen
RP Spindler, N (通讯作者)，Univ Klin Orthopadie Unfallchirurg & Plast Chirur, Abt Plast Asthet & Spezielle Handchirurg, Liebigstr 20, D-04103 Leipzig, Germany.
EM nick.spindler@medizin.uni-leipzig.de
CR Borger MA, 1998, ANN THORAC SURG, V65, P1050, DOI 10.1016/S0003-4975(98)00063-0
   Filsoufi F, 2009, J CARDIOTHOR VASC AN, V23, P488, DOI 10.1053/j.jvca.2009.02.007
   Funkat A, 2014, THORAC CARDIOV SURG, V62, P380, DOI 10.1055/s-0034-1383430
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NR 10
TC 17
Z9 22
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD MAR
PY 2015
VL 86
IS 3
BP 228
EP 233
DI 10.1007/s00104-014-2833-8
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE1WL
UT WOS:000351603500004
PM 25693778
DA 2026-07-24
ER
PT J
AU Dessy, LA
   Serratore, F
   Corrias, F
   Parisi, P
   Mazzocchi, M
   Carlesimo, B
AF Dessy, Luca A.
   Serratore, Francesco
   Corrias, Federico
   Parisi, Paola
   Mazzocchi, Marco
   Carlesimo, Bruno
TI Retention of polyurethane foam fragments during VAC therapy: a
   complication to be considered
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Foam-fragments retention; Healing; Negative pressure therapy
ID NEGATIVE-PRESSURE THERAPY; SPINAL WOUND INFECTIONS; THICKNESS
   SKIN-GRAFTS; ASSISTED CLOSURE; TRIAL
AB Vacuum-assisted closure (VAC) therapy is a closed-loop, non-invasive active system, characterised by a controlled and localised negative pressure applied on porous polyurethane absorbent foams. It promotes healing of acute and chronic wounds. Therapeutic effects of VAC therapy have been proved and demonstrated; however, this method can have some disadvantages. Even if it is a quite versatile device, only qualified medical/paramedical personnel should use it in order to avoid possible complications that can occur after an improper application. In this report, 11 cases of foam-fragment retention within the wound are presented. This rare complication did not promote healing, but further hindered it. On the basis of our experience, it is mandatory to define the indications, benefits and limitations of VAC therapy.
C1 [Dessy, Luca A.; Serratore, Francesco; Corrias, Federico; Parisi, Paola; Carlesimo, Bruno] Univ Roma La Sapienza, Dept Plast & Reconstruct Surg, I-00185 Rome, Italy.
   [Mazzocchi, Marco] Univ Perugia, Dept Plast & Reconstruct Surg, I-06100 Perugia, Italy.
C3 Sapienza University Rome; University of Perugia
RP Serratore, F (通讯作者)，Univ Roma La Sapienza, Dept Plast & Reconstruct Surg, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
EM serratorefrancesco@yahoo.it
RI PARISI, PAOLA/ACJ-8116-2022
OI PARISI, PAOLA/0000-0003-2639-2957
FU NHLBI NIH HHS [R01 HL066053] Funding Source: Medline; Wellcome Trust
   Funding Source: Medline
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NR 30
TC 12
Z9 15
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2015
VL 12
IS 2
BP 132
EP 136
DI 10.1111/iwj.12062
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CE2EI
UT WOS:000351626400003
PM 23590296
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Lindstedt, S
   Malmsjö, M
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Ingemansson, Richard
TI C-reactive protein and leucocyte counts drop faster using the
   HeartShield® device in patients with DSWI
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE C-reactive protein; Deep sternal wound infection; HeartShield (R);
   Negative pressure therapy; Right ventricular rupture
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; PREVENT HEART RUPTURE;
   POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY; RIGID BARRIER; INFECTION;
   EXPERIENCE; ALGORITHM
AB Right ventricular heart rupture is a devastating complication associated with negative pressure wound therapy (NPWT) in cardiac surgery. The use of a rigid barrier disc (HeartShield) has been suggested to offer protection against this lethal complication by preventing the heart from being drawn up by the negative pressure and damaged by the sharp sternum bone edges. Seven patients treated with conventional NPWT and seven patients treated with NPWT with a protective barrier disc (HeartShield) were compared with regard to bacterial clearance and infection parameters including C-reactive protein levels and leucocyte counts. C-reactive protein levels and leucocyte counts dropped faster and bacterial clearance occurred earlier in the HeartShield (R) group compared with the conventional NPWT group. Negative biopsy cultures were shown after 31 +/- 04 NPWT dressing changes in the HeartShield group, and after 54 +/- 06 NPWT dressing changes in the conventional NPWT group (P<0001). All patients were followed up with clinical check-up after 3months. None of the patients in the HeartShield group had any signs of reinfection such as deep sternal wound infection (DSWI) or sternal fistulas, whereas in the conventional NPWT group, two patients had signs of sternal fistulas that demanded hospitalisation. HeartShield hinders the right ventricle to come into contact with the sharp sternal edges during NPWT and thereby protects from heart damage. This study shows that using HeartShield is beneficial in treating patients with DSWI. Improved wound healing by HeartShield may be a result of the efficient drainage of wound effluents from the thoracic cavity.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Lindstedt, Sandra; Malmsjo, Malin; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@med.lu.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473;
   Ingemansson, Richard/0000-0001-7623-8953
CR [Anonymous], 2009, SER COMPL ASS NEG PR
   [Anonymous], 2011, FDA SAF COMM UPDATE
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NR 28
TC 2
Z9 2
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2015
VL 12
IS 2
BP 189
EP 194
DI 10.1111/iwj.12079
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CE2EI
UT WOS:000351626400013
PM 23651118
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Hudson, DA
   Adams, KG
   Van Huyssteen, A
   Martin, R
   Huddleston, EM
AF Hudson, Donald A.
   Adams, Kevin G.
   Van Huyssteen, Adriaan
   Martin, Robin
   Huddleston, Elizabeth M.
TI Simplified negative pressure wound therapy: clinical evaluation of an
   ultraportable, no-canister system
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Closed surgical incision; Negative pressure wound therapy; Portable;
   Postoperative care; Wound healing
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; CLOSED INCISION
   MANAGEMENT; SURGICAL INCISIONS; DEHISCENCE; FRACTURES; SURGERY; DEVICE;
   MODEL
AB The aim of this study was to evaluate a prototype negative pressure wound therapy (NPWT) system that has been developed to simplify NPWT for wounds at the lower end of the acuity scale. The new device has a single preset pressure of -80mmHg, is single use and operates without an exudate canister. The disposable NPWT system (PICO) was tested in a prospective, non-comparative, multicentre clinical trial to assess device functionality and clinical acceptance. Twenty patients were recruited for a maximum treatment period of 14days. The NPWT devices were fitted with data log chips to enable longitudinal assessment of negative pressure and leak rates during therapy. Sixteen (80%) patients had closed surgical wounds, two (10%) patients had traumatic wounds and two (10%) patients received meshed split thickness skin grafts. The mean study duration was 107days (range: 5-14days) and the mean dressing wear time per individual patient was 46days (range: 2-11). Fifty-five percent of wounds had closed by the end of the 14-day study or earlier, with a further 40% of wounds progressing to closure. Real-time pressure monitoring showed continuous delivery of NPWT. Three cases are discussed representing different wound locations and different patient factors that can increase the risk of post-surgical complications. Clinical studies of the disposable NPWT system confirmed the ability of the simplified single-use device to function consistently over the expected wear time. The anticipated reduced costs, ease of use and increased mobility of patients using this system may enable NPWT benefits to be available to a greater proportion of patients.
C1 [Hudson, Donald A.; Adams, Kevin G.] Groote Schuur Hosp, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
   [Hudson, Donald A.; Adams, Kevin G.] Univ Cape Town, ZA-7925 Cape Town, South Africa.
   [Van Huyssteen, Adriaan] Panorama Medi Clin, Orthopaed Hip & Knee Surg, Cape Town, South Africa.
   [Martin, Robin; Huddleston, Elizabeth M.] Smith & Nephew Med Ltd, Adv Wound Management Div, Kingston Upon Hull, N Humberside, England.
C3 University of Cape Town; University of Cape Town; Smith & Nephew
RP Huddleston, EM (通讯作者)，Smith & Nephew Med Ltd, Adv Wound Management Div, POB 81 101 Hessle Rd, Kingston Upon Hull, N Humberside, England.
EM elizabeth.huddleston@smith-nephew.com
OI Martin, Robin/0000-0002-9314-0437
FU Smith Nephew Ltd.
FX This work was funded by Smith & Nephew Ltd. EH and RM are employees of
   Smith & Nephew. The authors would like to thank Ben Askem (Smith &
   Nephew Hull) for providing data analysis and evaluation of the device
   data loggers and 3 Degree Clinical Research Organisation in South Africa
   for clinical trial monitoring services.
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NR 28
TC 55
Z9 61
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2015
VL 12
IS 2
BP 195
EP 201
DI 10.1111/iwj.12080
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CE2EI
UT WOS:000351626400014
PM 23647737
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Scalise, A
   Tartaglione, C
   Bolletta, E
   Calamita, R
   Nicoletti, G
   Pierangeli, M
   Grassetti, L
   Di Benedetto, G
AF Scalise, Alessandro
   Tartaglione, Caterina
   Bolletta, Elisa
   Calamita, Roberto
   Nicoletti, Giovanni
   Pierangeli, Marina
   Grassetti, Luca
   Di Benedetto, Giovanni
TI The enhanced healing of a high-risk, clean, sutured surgical incision by
   prophylactic negative pressure wound therapy as delivered by Prevena™
   Customizable™ : cosmetic and therapeutic results
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Surgical incision; Surgical wound
   infection; Wound healing
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; BLOOD-FLOW; SITE
   INFECTIONS; MANAGEMENT; HEALTH; DEHISCENCE
AB According to the literature, incisional closure complications may range from postoperative surgical site infections, representing 17-22% of health care-associated infections, surgical wound dehiscence and formation of haematomas or seromas, and can lead to delayed or impaired incision healing. These kinds of situations are more common when wounds are closed under tension or in specific patient morbidities. Obesity, in particular, is associated with an impaired blood flow to tissues, predisposing the patient to increased risk of wound complications by various mechanisms. Incisional complications can become relevant economic burdens for health care systems because of an increase in the average length of hospital stay and readmissions, and additional medical and surgical procedures. Thus, a preventive therapy may have a critical role in the management of healing. Negative pressure wound therapy (NPWT) technology as delivered by Prevena Customizable (Kinetic Concepts Inc., San Antonio, TX) has recently been the focus of a new investigation, as a prophylactic measure to prevent complications via immediate postoperative application in high-risk, clean, closed surgical incisions. The authors present a 62-year-old class II obese female, who underwent bilateral inguinal dermolipectomy. Prophylactic NPWT as delivered by Prevena was performed successfully over surgical incisions. Cosmetic and therapeutic results are shown.
C1 [Scalise, Alessandro; Tartaglione, Caterina; Bolletta, Elisa; Calamita, Roberto; Pierangeli, Marina; Grassetti, Luca; Di Benedetto, Giovanni] Univ Politecn Marche, Dept Plast & Reconstruct Surg, I-60126 Ancona, Italy.
   [Nicoletti, Giovanni] Univ Pavia, Dept Plast & Reconstruct Surg, I-27100 Pavia, Italy.
   [Nicoletti, Giovanni] Univ Pavia, Dept Diagnost Paediat Clin & Surg Sci, I-27100 Pavia, Italy.
C3 Marche Polytechnic University; University of Pavia; University of Pavia
RP Scalise, A (通讯作者)，Univ Politecn Marche, Dept Plast & Reconstruct Surg, Via Conca 71, I-60126 Ancona, Italy.
EM a.scalise@univpm.it
RI ; Nicoletti, Giovanni/Q-4356-2019
OI Grassetti, Luca/0000-0002-8856-7997; Nicoletti,
   Giovanni/0000-0002-1507-4067; Scalise, Alessandro/0000-0002-9198-4943
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NR 49
TC 23
Z9 27
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2015
VL 12
IS 2
BP 218
EP 223
DI 10.1111/iwj.12370
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CE2EI
UT WOS:000351626400017
PM 25234139
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Prasetyono, TOH
   Rini, IS
   Wibisono, C
AF Prasetyono, Theddeus O. H.
   Rini, Irena Sakura
   Wibisono, Cindy
TI EASEPort NPWT System to Enhance Skin Graft Survival - A Simple Assembly
SO INTERNATIONAL SURGERY
LA English
DT Article
DE Bandages; Foreign body; Exudate and transudate; Skin transplantation
   Wound; healing
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; NEGATIVE-PRESSURE;
   TRIAL; MODEL
AB Skin graft has been known to be prone to failure. This study was aimed to make a simplification of the negative pressure wound therapy (NPWT), which follows EASEPort (effective, affordable, safe, easily handled, and portable) concept to support the take of skin graft. The design of the EASEPort-NPWT was then made and technically verified. Thereafter, an animal experimental study comparing the EASEPort-NPWT to the classic tie-over technique on skin graft over exudative wound was conducted. The EASEPortNPWT was verified to be able to yield and sustain the subatmospheric pressure needed. In the animal study, the treatment group showed better skin graft survival rate (97.55 +/- 11.18% take) than the control group (54.88 +/- 19.73%) on day-7. Histopathology examination showed good quality of the skin structures taken from the treatment group, which was better than the structures of the skin in the control group. In summary, this study has been able to fulfill its objective to create a device following EASEPort concept. Subsequently, the EASEPort-NPWT was able to enhance skin graft survival rate in exudative wound.
C1 [Prasetyono, Theddeus O. H.; Wibisono, Cindy] Univ Indonesia, Cipto Mangunkusumo Hosp, Dept Surg, Div Plast Surg,Fac Med, Jakarta 13410, Indonesia.
   [Rini, Irena Sakura] Dharmais Hosp, Dept Surg, Div Plast Surg, Jakarta, Indonesia.
C3 University of Indonesia; Dr. Cipto Mangunkusumo National Public
   Hospital; Dharmais Hospital
RP Prasetyono, TOH (通讯作者)，Univ Indonesia, Cipto Mangunkusumo Hosp, Dept Surg, Div Plast Surg, Jl Diponegoro 71, Jakarta 13410, Indonesia.
EM teddyohprasetyono@yahoo.com
RI Prasetyono, Theddeus/GSD-6856-2022
OI Rini, Irena Sakura/0000-0003-4173-5911
CR [Anonymous], 2004, VAC ASS CLOS THER WO, P1
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NR 19
TC 3
Z9 3
U1 0
U2 1
PU INT COLLEGE OF SURGEONS
PI CHICAGO
PA 1516 N LAKE SHORE DR, CHICAGO, IL 60610 USA
SN 0020-8868
J9 INT SURG
JI Int. Surg.
PD MAR
PY 2015
VL 100
IS 3
BP 518
EP 523
DI 10.9738/INTSURG-D-14-00029.1
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE2RX
UT WOS:000351665100024
PM 25785338
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Meagher, H
   Moloney, MC
   Grace, PA
AF Meagher, H.
   Moloney, M. Clarke
   Grace, P. A.
TI Conservative management of mesh-site infection in hernia repair surgery:
   a case series
SO HERNIA
LA English
DT Article
DE Infected mesh graft; Infected hernia; Conservative management; Negative
   pressure wound therapy; Abdominal hernia repair
ID RANDOMIZED CLINICAL-TRIAL; INCISIONAL HERNIAS; RISK-FACTORS;
   METAANALYSIS; PROSTHESIS; SUTURE
AB The aim of this study is to assess the outcome of conservative management of infected mesh grafts following abdominal wall hernia repair.
   This study retrospectively examined the charts of patients who developed mesh-site infection following surgery for abdominal hernia repair to determine how effective conservative management in the form of antibiotics and wound management was on the resolution of infection and wound healing.
   Over a period of 30 months, 13 patients developed infected mesh grafts post-hernia repair surgery. Twelve patients were successfully treated conservatively with local wound care and antibiotics if clinically indicated. One patient returned to theatre to have the infected mesh removed. Of the patients that healed eleven were treated with negative pressure wound therapy (VAC(A (R))).
   This series of case studies indicate that conservative management of abdominal wall-infected hernia mesh cases is likely to be successful.
C1 [Meagher, H.] Univ Hosp Limerick, Dept Nursing, Limerick, Ireland.
   [Moloney, M. Clarke; Grace, P. A.] Univ Hosp Limerick, Vasc Res Unit, Limerick, Ireland.
C3 University of Limerick; University of Limerick
RP Moloney, MC (通讯作者)，Univ Hosp Limerick, Vasc Res Unit, Limerick, Ireland.
EM mary.clarkemoloney@hse.ie
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NR 40
TC 32
Z9 45
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2015
VL 19
IS 2
BP 231
EP 237
DI 10.1007/s10029-013-1069-8
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE3BS
UT WOS:000351699800008
PM 23504138
DA 2026-07-24
ER
PT J
AU Olona, C
   Caro, A
   Duque, E
   Moreno, F
   Vadillo, J
   Rueda, JC
   Vicente, V
AF Olona, C.
   Caro, A.
   Duque, E.
   Moreno, F.
   Vadillo, J.
   Rueda, J. C.
   Vicente, V.
TI Comparative study of open abdomen treatment: ABThera™ vs. abdominal
   dressing™
SO HERNIA
LA English
DT Article
DE Negative pressure therapy; Open abdomen; Abdominal closure
ID VACUUM-ASSISTED CLOSURE; COMPARTMENT SYNDROME; MANAGEMENT; SURGERY;
   STRATEGIES; TRAUMA; SYSTEM
AB Negative pressure therapy (NPT) is a widely recognised procedure for the temporary closure of open abdominal wounds. In this study, we compare two NPT products, the V.A.C.A (R) abdominal dressing (AD) system and the new ABThera (TM) (ABT) system, in terms of the primary closure rates achieved, types of closure, and the associated morbidity.
   We employed a retrospective comparative study of open-abdomen patients treated with NPT using either AD or ABT. The indications for treatment were damage control surgery, abdominal compartment syndrome, or severe abdominal sepsis.
   The group of patients treated with ABT showed a higher percentage of primary closures (41 vs. 11 %) and required fewer days of NPT (17 vs. 26 days) than the AD group. Differences were statistically significant. In addition, only 4 % of patients in the ABT group exhibited enteroatmospheric fistulae, compared to 17 % in the AD group.
   Compared to the AD system, ABT can achieve faster primary closure after open abdomen treatment with only minor complications.
C1 [Olona, C.; Caro, A.; Duque, E.; Moreno, F.; Vadillo, J.; Rueda, J. C.; Vicente, V.] Univ Hosp Joan XXIII Tarragona, Digest & Gen Surg Dept, Tarragona 43007, Spain.
RP Olona, C (通讯作者)，Univ Hosp Joan XXIII Tarragona, Digest & Gen Surg Dept, 4th Dr Mallafre Guasch St 3th Floor, Tarragona 43007, Spain.
EM drcarlesolona@gmail.com
OI Caro, Aleidis/0000-0001-6151-3879; Vicente, Vicente/0000-0002-4278-3264
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Biondo S, 2012, CIR ESPAN, V90, P345, DOI 10.1016/j.ciresp.2011.12.007
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   Carlson GL, 2013, ANN SURG, V257, P1154, DOI 10.1097/SLA.0b013e31828b8bc8
   Caro A, 2011, INT WOUND J, V8, P274, DOI 10.1111/j.1742-481X.2011.00782.x
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   Cheatham ML, 2010, CRIT CARE MED, V38, P402, DOI 10.1097/CCM.0b013e3181b9e9b1
   DeOliveira ML, 2006, ANN SURG, V244, P931, DOI 10.1097/01.sla.0000246856.03918.9a
   Fortelny RH, 2014, SURG ENDOSC, V28, P735, DOI 10.1007/s00464-013-3251-6
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   MacLean AA, 2008, ACTA CHIR BELG, V108, P212, DOI 10.1080/00015458.2008.11680206
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   Perez D, 2007, J AM COLL SURGEONS, V205, P586, DOI 10.1016/j.jamcollsurg.2007.05.015
   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   Pliakos I, 2012, AM SURGEON, V78, P957
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NR 20
TC 20
Z9 20
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2015
VL 19
IS 2
BP 323
EP 328
DI 10.1007/s10029-014-1253-5
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE3BS
UT WOS:000351699800021
PM 24756917
DA 2026-07-24
ER
PT J
AU Nolff, MC
   Meyer-Lindenberg, A
AF Nolff, M. C.
   Meyer-Lindenberg, A.
TI Necrotising fasciitis in a domestic shorthair cat - negative pressure
   wound therapy assisted debridement and reconstruction
SO JOURNAL OF SMALL ANIMAL PRACTICE
LA English
DT Article
ID SKIN; CLOSURE; MANAGEMENT; DIAGNOSIS
AB A 10-year-old, domestic shorthair cat was presented for acute lameness of the left forelimb accompanied by severe pain, swelling, skin necrosis, malodorous discharge and pyrexia. Following a presumptive diagnosis of necrotising fasciitis aggressive surgical debridement of the affected soft tissues of the antebrachium and negative pressure wound treatment of the open defect were performed. Surgical findings supported the tentative diagnosis of necrotising fasciitis and Streptococcus canis was isolated from the wound. A free skin graft was performed 29 days after admission, and augmented by 3 days of negative pressure wound therapy to facilitate graft incorporation. Healing was achieved without complications and no functional or aesthetic abnormalities remained.
C1 [Nolff, M. C.; Meyer-Lindenberg, A.] Univ Munich, Clin Small Anim Surg & Reprod, Munich, Germany.
C3 University of Munich
RP Nolff, MC (通讯作者)，Univ Munich, Clin Small Anim Surg & Reprod, Munich, Germany.
RI Meyer-Lindenberg, Andrea/H-1076-2011; Nolff, Mirja/W-6756-2019
OI Meyer-Lindenberg, Andrea/0000-0001-6137-3773; Nolff,
   Mirja/0000-0001-9317-7769
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   [Anonymous], 34 ANN M AM BURN ASS
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   Cunningham JD, 2001, MT SINAI J MED, V68, P253
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   Guille AE, 2007, JAVMA-J AM VET MED A, V230, P1669, DOI 10.2460/javma.230.11.1669
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   Simman R, 2004, WOUNDS, V16, P76
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   Steinstraesser L, 2009, INT J LOW EXTR WOUND, V8, P28, DOI 10.1177/1534734609331991
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NR 22
TC 12
Z9 12
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4510
EI 1748-5827
J9 J SMALL ANIM PRACT
JI J. Small Anim. Pract.
PD APR
PY 2015
VL 56
IS 4
BP 281
EP 284
DI 10.1111/jsap.12275
PG 4
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CE4BN
UT WOS:000351775900009
PM 25323110
DA 2026-07-24
ER
PT J
AU Yang, CK
   Alcantara, S
   Goss, S
   Lantis, JC
AF Yang, C. Kevin
   Alcantara, Sean
   Goss, Selena
   Lantis, John C., II
TI Cost analysis of negative-pressure wound therapy with instillation for
   wound bed preparation preceding split-thickness skin grafts for massive
   (&gt;100 cm2) chronic venous leg ulcers
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PATIENT
AB Objective: Massive (>= 100 cm(2)) venous leg ulcers (VLUs) demonstrate very low closure rates with standard compression therapy and are costly to manage. Negative-pressure wound therapy (NPWT), followed by a split-thickness skin graft (STSG), can be a cost-effective alternative to this standard care. We performed a cost analysis of these two treatments.
   Methods: A retrospective review was performed of 10 ulcers treated with surgical debridement, 7 days of inpatient NPWT with topical antiseptic instillation (NPWTi), and STSG, with 4 additional days of inpatient NPWT bolster over the graft. Independent medical cost estimators were used to compare the cost of this treatment protocol with standard outpatient compression therapy.
   Results: The average length of time ulcers were present before patients entered the study was 38 months (range, 3-120 months). Eight of 10 patients had complete VLU closure by 6 months after NPWTi with STSG. The 6-month costs of the proposed treatment protocol and standard twice-weekly compression therapy were estimated to be $27,000 and $28,000, respectively.
   Conclusions: NPWTi with STSG treatment is more effective for closure of massive VLUs at 6 months than that reported for standard compression therapy. Further, the cost of the proposed treatment protocol is comparable with standard compression therapy.
C1 [Lantis, John C., II] Mt Sinai St Lukes Hosp, New York, NY 10025 USA.
   [Lantis, John C., II] Mt Sinai Roosevelt Hosp, New York, NY 10025 USA.
C3 Mount Sinai Morningside; Mount Sinai West
RP Lantis, JC (通讯作者)，Mt Sinai St Lukes Hosp, 1090 Amsterdam Ave,Ste 7A, New York, NY 10025 USA.
EM jlantis@chpnet.org
FU KCI (San Antonio, Tex)
FX J. C. L. is a paid consultant for KCI (San Antonio, Tex).
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NR 29
TC 25
Z9 28
U1 0
U2 12
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD APR
PY 2015
VL 61
IS 4
BP 995
EP 999
DI 10.1016/j.jvs.2014.11.076
PG 5
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA CE4BP
UT WOS:000351776100024
PM 25595397
OA Bronze
DA 2026-07-24
ER
PT J
AU Mody, GN
   Zurovcik, DR
   Joharifard, S
   Kansayisa, G
   Uwimana, G
   Baganizi, E
   Ntakiyiruta, G
   Mugenzi, D
   Riviello, R
AF Mody, Gita N.
   Zurovcik, Danielle R.
   Joharifard, Shahrzad
   Kansayisa, Grace
   Uwimana, Gemimah
   Baganizi, Erick
   Ntakiyiruta, Georges
   Mugenzi, Dominique
   Riviello, Robert
TI Biomechanical and Safety Testing of a Simplified Negative-Pressure Wound
   Therapy Device
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; CLOSURE; UPDATE
AB Background: There is a large, unmet need for acute and chronic wound care worldwide. Application of proven therapies such as negative-pressure wound therapy in resource-constrained settings is limited by cost and lack of electrical supply. To provide an alternative to existing electrically powered negative-pressure wound therapy systems, a bellows-powered negative-pressure wound therapy system was designed and iteratively improved during field-based testing. The authors describe the design process and the results of safety and biomechanical testing of their simplified negative-pressure wound therapy system.
   Methods: Simplified negative-pressure wound therapy was tested at two hospitals in Rwanda. Patients with wounds ranging from 2 to 150 cm(2) and meeting inclusion and exclusion criteria were enrolled. Wounds were categorized by difficulty of dressing application according to location and contour. Outcomes were maintenance of negative pressure and occurrence of adverse events.
   Results: Thirty-seven patients with 42 wounds were treated with simplified negative-pressure wound therapy. Eighty-five dressings in total were applied. On average, the final simplified negative-pressure wound therapy dressing maintained negative pressure for 31.7 hours on all wounds (n = 37), and 52.7 hours on wounds in easy-to-dress locations. No unexpected adverse events occurred.
   Conclusions: This is the first systematic report of the performance of a bellows-powered negative-pressure wound therapy device designed specifically for use in resource-constrained settings. The authors found that elimination of air leaks in the simplified negative-pressure wound therapy dressing is essential, and that their system is safe and feasible for use in these environments. Subsequent trials will study the system's efficacy.
C1 [Mody, Gita N.] Brigham & Womens Hosp, Ctr Surg & Publ Hlth, Dept Gen Surg, Boston, MA 02115 USA.
   Worldwide Innovat Healthcare Inc, Boston, MA USA.
   Univ British Columbia, Dept Surg, Vancouver, BC V5Z 1M9, Canada.
   Natl Univ Rwanda, Butaro, Rwanda.
   Rwinkwavu Hosp, Dept Nursing, Butaro, Rwanda.
   Drew Cares Int, Kigali, Rwanda.
   Natl Univ Rwanda, Kigali Univ Teaching Hospital, Dept Surg, Butare, Rwanda.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; University of British Columbia; University of Rwanda;
   University of Rwanda
RP Mody, GN (通讯作者)，Brigham & Womens Hosp, Ctr Surg & Publ Hlth, Dept Gen Surg, 75 Francis St, Boston, MA 02115 USA.
EM gmody@partners.org
RI ; Mody, Gita/KQV-0468-2024
OI Joharifard, Shahrzad/0000-0002-0202-8758; Mody, Gita/0000-0003-0218-6948
FU Fogarty International Clinical Research Fellowship; Vanderbilt
   University [R24 TW007988]; Hugh Hampton Young Memorial Fund Fellowship;
   Massachusetts Institute of Technology Legatum Center
FX The authors would like to acknowledge the Fogarty International Clinical
   Research Fellowship, the National Institutes for Health and
   International Clinical Research Fellows Program at Vanderbilt University
   (R24 TW007988), the Hugh Hampton Young Memorial Fund Fellowship, and the
   Massachusetts Institute of Technology Legatum Center for financial
   support of the project. They would like to thank the Ministry of Health
   of Rwanda for promoting a culture of innovation and equity in patient
   care. Lastly, they would like to acknowledge the staff at Rwinkwavu
   Hospital, Inshuti Mu Buzima/Partners In Health, and Kigali University
   Teaching Hospital for their collaboration and support and their
   commitment to improving patient care on a daily basis.
CR Armstrong DG, 2011, PLAST RECONSTR SURG, V127, p116S, DOI 10.1097/PRS.0b013e3181fb5431
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Flack S, 2008, J Wound Care, V17, P71
   Fong KD, 2010, PLAST RECONSTR SURG, V125, P1362, DOI 10.1097/PRS.0b013e3181d62b25
   KOSTIUCHENOK BM, 1986, VESTN KHIR IM GREKOV, V137, P18
   Landsman Adam, 2010, J Diabetes Sci Technol, V4, P831
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   Mouës CM, 2011, AM J SURG, V201, P544, DOI 10.1016/j.amjsurg.2010.04.029
   Murray CJL, 2012, LANCET, V380, P2197, DOI [10.1016/S0140-6736(12)61689-4, 10.1016/S0140-6736(12)61729-2]
   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Orgill DP, 2011, PLAST RECONSTR SURG, V127, p105S, DOI 10.1097/PRS.0b013e318200a427
   Perez D, 2010, AM J SURG, V199, P14, DOI 10.1016/j.amjsurg.2008.12.029
   Zurovcik D, 2011, IEEE GLOB HUM TECHN
   Zurovcik D, 2007, DEV SIMPLIFIED NEGAT
NR 17
TC 5
Z9 7
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR
PY 2015
VL 135
IS 4
BP 1140
EP 1146
DI 10.1097/PRS.0000000000001101
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE5XU
UT WOS:000351910200053
PM 25502858
DA 2026-07-24
ER
PT J
AU Perentes, JY
   Abdelnour-Berchtold, E
   Blatter, J
   Lovis, A
   Ris, HB
   Krueger, T
   Gonzalez, M
AF Perentes, Jean Yannis
   Abdelnour-Berchtold, Etienne
   Blatter, Jeannine
   Lovis, Alban
   Ris, Hans-Beat
   Krueger, Thorsten
   Gonzalez, Michel
TI Vacuum-assisted closure device for the management of infected
   postpneumonectomy chest cavities
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID ACCELERATED TREATMENT; MUSCLE TRANSPOSITION; EMPYEMA; THERAPY;
   EXPERIENCE
AB Background: Infected postpneumonectomy chest cavities may be related to chronic postpneumonectomy empyema or arise in rare situations of necrotizing pneumonia with complete lung destruction where pneumonectomy and pleural debridement are required. We evaluated the safety and efficacy of an intrathoracic vacuum-assisted closure device (VAC) for the treatment of infected postpneumonectomy chest cavities.
   Method: A retrospective single institution review of all patients with infected postpneumonectomy chest cavities treated by VAC between 2005 and 2013. Patients underwent surgical debridement of the thoracic cavity, muscle flap closure of the bronchial stump when a fistula was present, and repeated intrathoracic VAC dressings until granulation tissue covered the entire chest cavity. After this, the cavity was obliterated by a Clagett procedure and closed.
   Results: Twenty-one patients (14 men and 7 women) underwent VAC treatment of their infected postpneumonectomy chest cavity. Twelve patients presented with a chronic postpneumonectomy empyema (10 of them with a bronchopleural fistula) and 9 patients with an empyema occurring in the context of necrotizing pneumonia treated by pneumonectomy. In-hospital mortality was 23%. The median duration of VAC therapy was 23 days (range, 4-61 days) and the median number of VAC changes per patient was 6 (range, 2-14 days). Infection control and successful chest cavity closure was achieved in all surviving patients. One adverse VAC treatment-related event was identified (5%).
   Conclusions: The intrathoracic VAC application is a safe and efficient treatment of infected postpneumonectomy chest cavities and allows the preservation of chest wall integrity.
C1 [Perentes, Jean Yannis; Abdelnour-Berchtold, Etienne; Blatter, Jeannine; Ris, Hans-Beat; Krueger, Thorsten; Gonzalez, Michel] CHU Vaudois, Div Thorac Surg, CH-1011 Lausanne, Switzerland.
   [Lovis, Alban] CHU Vaudois, Div Pneumol, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Gonzalez, M (通讯作者)，CHU Vaudois, Div Thorac Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM Michel.Gonzalez@chuv.ch
RI ; Krueger, Thorsten/AAK-1780-2021
OI Perentes, Jean/0000-0001-7918-0793; gonzalez,
   michel/0000-0001-8705-4279; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 26
TC 23
Z9 34
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD MAR
PY 2015
VL 149
IS 3
BP 745
EP 750
DI 10.1016/j.jtcvs.2014.10.052
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA CE6EX
UT WOS:000351930600038
PM 25454910
OA Bronze
DA 2026-07-24
ER
PT J
AU Schulz, D
   Mohor, GS
   Solovan, C
AF Schulz, Dietmar
   Mohor, Georgiana Simona
   Solovan, Caius
TI Unusual foreign body in the sigmoid colon, chronic alcohol abuse, and
   Fournier gangrene: a case report
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE pancreatic stent; wound debridement; vacuum-assisted closure;
   transplanted skin; necrotizing infection
AB Fournier gangrene (FG) is an infectious condition with fulminant evolution and is sometimes life-threatening. Here, we present the case of an immunocompromised 59-year-old male with surgical history of a pancreatic pseudocyst stented endoscopically. After unrecognized stent migration in the sigmoid without colonic perforation, he developed severe necrosis of the scrotum and perineum, which spontaneously perforated, presenting a smell suggesting moist gangrene. FG that has spread to the male genital organs presents therapeutic challenges. The purpose of our study is to present this case, typical for FG, with an educational aim both for the internal and surgical specialties, and the goal of further multidisciplinary collaboration for the optimal management of the patient with personalized treatment.
C1 [Schulz, Dietmar] Sana Kliniken Leipziger Land, Urol Klin, Leipzig, Germany.
   [Mohor, Georgiana Simona; Solovan, Caius] Univ Clin Dermatol & Venereol, Timisoara, Romania.
   [Solovan, Caius] Victor Babes Univ Med & Pharm, Dept Dermatol, Timisoara, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara
RP Mohor, GS (通讯作者)，Univ Clin Dermatol & Venereol, Marasesti Nr 5, Timisoara, Romania.
EM simona.mohor@gmx.de
CR Ahmadnia H, 2009, URO TODAY INT J, V2
   [Anonymous], 1883, SEMIN MED
   [Anonymous], COCHRANE DATABASE SY, DOI DOI 10.1002/14651858.CD007937.PUB2
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   Grabe M., 2011, Guidelines on urological infections
   Kujath P, 2002, DEUT MED WOCHENSCHR, V127, P2508, DOI 10.1055/s-2002-35644
   Marsman J W, 1996, Australas Radiol, V40, P80
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   Pais Jr VM, MEDSCAPE
   Papachristodoulou AJ, 1997, LANGENBECK ARCH CHIR, V382, P15, DOI 10.1007/BF02539302
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   Pour SM, 2011, J WOUND OSTOMY CONT, V38, P449, DOI 10.1097/WON.0b013e31821e43f1
   Wróblewska M, 2014, POL J MICROBIOL, V63, P267
   Yilmazlar T, 2014, ULUS TRAVMA ACIL CER, V20, P333, DOI 10.5505/tjtes.2014.06870
NR 16
TC 4
Z9 4
U1 0
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2015
VL 10
BP 673
EP 677
DI 10.2147/CIA.S79609
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA CE7IY
UT WOS:000352013800001
PM 25878494
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, J
   Zhang, H
   Wang, S
AF Wang, J.
   Zhang, H.
   Wang, S.
TI Application of vacuum sealing drainage in the treatment of internal
   fixation instrument exposure after early postoperative infection
SO MINERVA CHIRURGICA
LA English
DT Article
DE Drainage; Infection; Bone plates
ID POSTERIOR SPINAL-FUSION; ASSISTED WOUND CLOSURE; MANAGEMENT
AB Aim. This retrospective study aimed to investigate the effect of vacuum sealing drainage (VSD) in the management of fractured patients with internal fixation instrument exposure caused by early postoperative infection after open reduction and internal fixation (ORIF).
   Methods. Fourteen patients (11 men, 3 women, age range 9-63 years) with spinal and extremities fractures were enrolled in this study, including atlanto-axial fracture (N.=1), thoraco-lumbar fracture (N.=1), humerus fracture (N.=1), femoral fracture (N.=2), humerus fracture together with femoral fracture (N.=1), fracture of tibia and fibula (N.=3), L1 vertebral fracture together with tibia and fibula fracture (N.=2), Li vertebral fracture (N.=2) and L1 vertebral fracture complicated by type II diabetes (N.=1). Infections occurred at the surgical incisions 1-7 days after ORIF operation. Deep spread of the infection caused exposure of internal fixation device. All patients underwent local debridement with retention of internal fixation device. VSD foam dressings containing the drainage tube were placed into the wound, covering external fixation devices and fully eliminating the dead space of soft tissue to avoid effusion. Continuous drainage and VSD irrigation was performed for 24 h with regular replacement of VSD.
   Results. After 14-43 days of VSD treatment, internal fixation devices were covered by healthy granulation tissue and complete wound healing was achieved. During a postoperative follow-up period of between 2 to 52 months, physical examinations and imaging studies of all patients showed good functional recovery, no loosening of internal fixation devices, and no systemic or local infection.
   Conclusion. The use of VSD, while retaining the internal fixation device can be safe and effective with earlier wound healing and functional recovery.
C1 [Wang, J.; Zhang, H.; Wang, S.] Lanzhou Univ, Hosp 2, Dept Orthoped, Lanzhou 730030, Gansu, Peoples R China.
   [Wang, S.] Orthoped Key Lab, Lanzhou, Gansu, Peoples R China.
C3 Lanzhou University
RP Wang, S (通讯作者)，Lanzhou Univ, Hosp 2, Dept Orthoped, Lanzhou 730030, Gansu, Peoples R China.
EM k.alpha@163.com
CR Fassett DR, 2004, SEMIN SPINE SURG, V16, P174
   Guangyu H., 2010, J Spinal Surg, V8, P278
   Halliman DG, 2004, CURR MICROBIOL, V48, P214, DOI 10.1007/s00284-003-4091-8
   Liu HD, 2010, CHINESE J BONE JOINT, V25, P1083
   Luo XB, 2010, J SPINE SURG, V8, P274
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   Picada R, 2000, J SPINAL DISORD, V13, P42, DOI 10.1097/00002517-200002000-00009
   Ploumis A, 2008, J SPINAL DISORD TECH, V21, P320, DOI 10.1097/BSD.0b013e318141f99d
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   Weinstein MA, 2000, J SPINAL DISORD, V13, P422, DOI 10.1097/00002517-200010000-00009
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   Zhang C, 2010, CHINESE J ORTHOPAEDI, V5, P496
NR 15
TC 18
Z9 39
U1 0
U2 6
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4733
EI 1827-1626
J9 MINERVA CHIR
JI Minerva Chir.
PD FEB
PY 2015
VL 70
IS 1
BP 17
EP 22
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE7PS
UT WOS:000352034400003
PM 25389757
DA 2026-07-24
ER
PT J
AU Zhang, F
   Lv, KY
   Qiu, XC
   Luo, PF
   Zheng, XF
   Zhu, SH
   Xia, ZF
AF Zhang, Fang
   Lv, Kai-Yang
   Qiu, Xiao-Chen
   Luo, Peng-Fei
   Zheng, Xing-Feng
   Zhu, Shi-Hui
   Xia, Zhao-Fan
TI Using negative pressure wound therapy on microskin autograft wounds
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE NPWT; Skin defect; Microskin graft; Skin grafting; Wound repair
ID OF-THE-LITERATURE; SKIN-GRAFTS; CLOSURE; TRIAL; MANAGEMENT; DEVICE; LEG
AB Background: Microskin autografts with conventional wrap and compression are used extensively in the treatment of skin and tissue defects. This comparative study aimed at investigation of the clinical application of negative pressure wound therapy (NPWT) in combination with microskin autografts for repair of acute and chronic wounds.
   Methods: A prospective case-control study was performed from December 1, 2010-December 31, 2013 in Changhai Hospital, Shanghai. We compared a study group of patients received microskin autografting covered by NPWT with that of a control group of patients received microskin autografting covered by a conventional gauze.
   Results: A total of 81 patients were in this study, 27 patients were allocated to the study group and 54 patients to the control group. The study group exhibited significant low infection rate and pain score during removal of inner layer at first dressing change after skin grafting compared with those of the control group (P < 0.05). The time interval between skin grafting and first postoperative change was longer in the study group than that in the control group (P < 0.01), the study group showed a significant shorter 95% wound healing time (P < 0.05), and survival rate of microskin autografts in the study group was higher than that in the control group (P < 0.05).
   Conclusions: NPWT is beneficial for wound closure after microskin autografts, which prolongs the interval between skin transplantation and first postoperative dressing change, reduces pain during removal of inner layer dressing, increases skin graft survival rate, and shortens wound healing time. Therefore, NPWT can be recommended for repair of acute and chronic wounds with microskin autografts. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Zhang, Fang; Lv, Kai-Yang; Luo, Peng-Fei; Zheng, Xing-Feng; Zhu, Shi-Hui; Xia, Zhao-Fan] Second Mil Med Univ, Affiliated Changhai Hosp, Dept Burn Surg, Shanghai 200433, Peoples R China.
   [Zhang, Fang] 73901 Troop PLA, Shanghai, Peoples R China.
   [Qiu, Xiao-Chen] 309th Hosp PLA, Dept Burns & Plast Surg, Beijing, Peoples R China.
C3 Naval Medical University
RP Zhu, SH (通讯作者)，Second Mil Med Univ, Affiliated Changhai Hosp, Dept Burn Surg, Shanghai 200433, Peoples R China.
EM doctorzhushihui@163.com; xiazhaofan@163.com
RI Zheng, Xingfeng/C-2982-2011
FU National Natural Science Foundation of China [81000308, 81120108015];
   Science and Technology Commission of Shanghai Municipality
   [12QA1404400]; 1255 Foundation of Changhai Hospital [CH125510207,
   CH125510208, CH125510212]
FX This work was financially supported by the key project of the National
   Natural Science Foundation of China (No. 81120108015), the National
   Natural Science Foundation of China (No. 81000308), the Science and
   Technology Commission of Shanghai Municipality (No. 12QA1404400) and the
   1255 Foundation of Changhai Hospital (No. CH125510207, CH125510208,
   CH125510212). The authors acknowledge Professor Sheng-De Ge for formal
   English revision of the article.
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NR 35
TC 16
Z9 20
U1 0
U2 19
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAY 1
PY 2015
VL 195
IS 1
BP 344
EP 350
DI 10.1016/j.jss.2014.12.025
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE9CA
UT WOS:000352139900044
PM 25586332
DA 2026-07-24
ER
PT J
AU Dale, AP
   Saeed, K
AF Dale, Adam P.
   Saeed, Kordo
TI Novel negative pressure wound therapy with instillation and the
   management of diabetic foot infections
SO CURRENT OPINION IN INFECTIOUS DISEASES
LA English
DT Review
DE diabetic foot infections; diabetes; diabetic foot; negative pressure
   wound therapy negative pressure wound therapy with instillation
ID VACUUM-ASSISTED CLOSURE; POLYHEXAMETHYLENE BIGUANIDE MOUTHRINSE;
   BACTERIAL COUNTS; ANTIMICROBIAL SOLUTIONS; CARE; ULCERS; POLYHEXANIDE;
   MULTICENTER; IRRIGATION; EXPERIENCE
AB Purpose of review
   The use of negative pressure wound therapy with instillation (NPWTi) in complex or difficult-to-treat acute and chronic wounds has expanded rapidly since the introduction of commercially available NPWTi systems. We summarize the evidence related to NPWTi and particularly focus on the application of this technology in diabetic foot ulcers, diabetic foot infections and postoperative diabetic wounds.
   Recent findings
   The benefits of negative pressure wound therapy (NPWT) are well documented in the treatment of complex acute and chronic wounds, including noninfected postoperative diabetic wounds and diabetic foot ulcers. Combining intermittent wound irrigation with NPWT may offer additional benefits compared to NPWT alone, including further reduction of wound bed bioburden, increased granulation tissue formation and provision of wound irrigation in a sealed environment, thus preventing potential cross-contamination events. Recently, available evidence suggests that adjunctive NPWTi may be superior to standard NPWT in the management of diabetic infections following surgical debridement and may promote granulation tissue formation in slow-to-heal wounds.
   Summary
   Available evidence relating to the utilization of NPWTi in diabetic foot infections is promising but limited in quality, being derived mostly from case series or small retrospective or prospective studies. In order to confirm or refute the potential benefits of NPWTi in this patient cohort, well designed randomized controlled studies are required that compare NPWTi to NPWT or standard wound care methodologies.
C1 [Dale, Adam P.; Saeed, Kordo] Hampshire Hosp NHS Fdn Trust, Royal Hampshire Cty Hosp, Dept Microbiol, Winchester SO22 5DG, Hants, England.
RP Saeed, K (通讯作者)，Hampshire Hosp NHS Fdn Trust, Royal Hampshire Cty Hosp, Romsey Rd, Winchester SO22 5DG, Hants, England.
EM kordosaeed@nhs.net
OI Dale, Adam/0000-0001-8163-7481; Saeed, Kordo/0000-0003-0123-0302
FU National Institute for Health Research [ACF-2014-26-005] Funding Source:
   researchfish
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NR 58
TC 18
Z9 24
U1 4
U2 33
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7375
EI 1473-6527
J9 CURR OPIN INFECT DIS
JI Curr. Opin. Infect. Dis.
PD APR
PY 2015
VL 28
IS 2
BP 151
EP 157
DI 10.1097/QCO.0000000000000146
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA CE9EW
UT WOS:000352147700005
PM 25692273
DA 2026-07-24
ER
PT J
AU Leaper, D
   Ousey, K
AF Leaper, David
   Ousey, Karen
TI Evidence update on prevention of surgical site infection
SO CURRENT OPINION IN INFECTIOUS DISEASES
LA English
DT Review
DE antibiotic prophylaxis; antimicrobial sutures; antiseptics; surgical
   dressings; surgical site infection
ID TRICLOSAN-COATED SUTURES; EDGE PROTECTION DEVICES; PRESSURE WOUND
   THERAPY; ANTIBIOTIC-PROPHYLAXIS; RISK; SURGERY; TRIAL; SURVEILLANCE;
   METAANALYSIS
AB Purpose of review
   Surgical site infection (SSI) is a common healthcare-associated infection and complicates up to 10-20% of operations with considerable strain on healthcare resources. Apart from the widely adopted use of appropriate hair removal, antibiotic prophylaxis, avoidance of hypothermia and perioperative glycaemic control to reduce SSIs, this review has considered new research and systematic reviews, and whether their findings should be included in guidelines.
   Recent findings
   The efficacy of preoperative bathing/showering, antibiotic prophylaxis for clean surgery and perioperative oxygen supplementation to reduce the risk of SSI is still in doubt. By contrast, the use of 2% chlorhexidine in alcohol skin preparation, postoperative negative pressure wound therapy and antiseptic surgical dressings do show promise. Antimicrobial sutures in independent meta-analyses were found to reduce the risk of SSI after all classes of surgery (except dirty) whereas the use of wound guards, or diathermy skin incision (compared with scalpel incision), did not.
   Summary
   The incidence of SSI after surgery is not falling. Based on this review of published trials and evidence-based systematic reviews some advances might be included into these care bundles. More research is needed together with improved compliance with care bundles.
C1 [Leaper, David; Ousey, Karen] Univ Huddersfield, Sch Human & Hlth Sci, Inst Skin Integr & Infect Prevent, Huddersfield HD1 3DH, W Yorkshire, England.
C3 University of Huddersfield
RP Leaper, D (通讯作者)，Univ Huddersfield, Sch Human & Hlth Sci, Inst Skin Integr & Infect Prevent, Huddersfield HD1 3DH, W Yorkshire, England.
EM profdavidleaper@doctors.org.uk
RI Ousey, Karen/W-1881-2018
OI Ousey, Karen/0000-0002-6993-9425
FU Johnson and Johnson; Smith and Nephew; Carefusion
FX In the last 5 years D.L. has acted in an advisory capacity or been
   supported financially in sponsored symposia for Ethicon (Johnson and
   Johnson), Smith and Nephew and Carefusion. K.O. has no conflicts of
   interest.
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NR 52
TC 69
Z9 89
U1 0
U2 50
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7375
EI 1473-6527
J9 CURR OPIN INFECT DIS
JI Curr. Opin. Infect. Dis.
PD APR
PY 2015
VL 28
IS 2
BP 158
EP 163
DI 10.1097/QCO.0000000000000144
PG 6
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA CE9EW
UT WOS:000352147700006
PM 25692267
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Boo, YJ
   Nam, MH
   Lee, EH
   Lee, KC
AF Boo, Yoon Jung
   Nam, Myung Hyun
   Lee, Eun Hee
   Lee, Kuang Chul
TI Cyclic neutropenia with a novel gene mutation presenting with a
   necrotizing soft tissue infection and severe sepsis: case report
SO BMC PEDIATRICS
LA English
DT Article
DE Cyclic neutropenia; Soft tissue infection; Necrotizing;
   Negative-pressure wound therapy
ID FASCIITIS
AB Background: Cyclic neutropenia is a rare disease. We report a 31-month-old girl with congenital cyclic neutropenia with a novel mutation in the ELANE gene who developed an acute necrotizing soft-tissue infection on her left axillary legion.
   Case presentation: A 31-month-old girl was admitted to our pediatric emergency room because of a necrotizing soft tissue infection of the left axillary area. The infection progressed rapidly and resulted in septic shock. Despite a medical treatment and surgical debridement, the sepsis was not controlled, and severe inflammation developed. After applying of negative-pressure wound therapy, her clinical symptoms improved. Finally, she was diagnosed with cyclic neutropenia with a novel genetic mutation. One month after admission, she was discharged with a completely recovered wound and no need for skin grafting.
   Conclusion: Both adequate medical treatment and effective control of the source of infection are critically important to reduce morbidity in such complex cases of necrotizing fasciitis as appeared in an immunocompromised pediatric patient.
C1 [Boo, Yoon Jung] Korea Univ, Div Pediat Surg, Dept Surg, Coll Med, Seoul 136705, South Korea.
   [Nam, Myung Hyun] Korea Univ, Coll Med, Dept Lab Med, Seoul 136705, South Korea.
   [Lee, Eun Hee; Lee, Kuang Chul] Korea Univ, Coll Med, Dept Pediat, Seoul 136705, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine); Korea University;
   Korea University Medicine (KU Medicine)
RP Boo, YJ (通讯作者)，Korea Univ, Div Pediat Surg, Dept Surg, Coll Med, 73 Inchonro, Seoul 136705, South Korea.
EM drboo@korea.ac.kr; myunghyun.nam@gmail.com
OI Nam, Myung-Hyun/0000-0002-8737-6902
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
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NR 10
TC 8
Z9 12
U1 0
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD APR 2
PY 2015
VL 15
AR 34
DI 10.1186/s12887-015-0352-5
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA CE9UD
UT WOS:000352188000001
PM 25880377
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pepe, G
   Magalini, S
   Callari, C
   Persiani, R
   Lodoli, C
   Gui, D
AF Pepe, G.
   Magalini, S.
   Callari, C.
   Persiani, R.
   Lodoli, C.
   Gui, D.
TI Vacuum Assisted Closure (VAC) therapy™ as a swiss knife multi-tool for
   enteric fistula closure: tips and tricks: a pilot study
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Enterocutaneous fistula management; VAC therapy (TM)
ID ENTEROCUTANEOUS FISTULAS; OPEN ABDOMEN; NEGATIVE-PRESSURE; MANAGEMENT;
   METAANALYSIS; WOUNDS; SYSTEM
AB OBJECTIVE: Enterocutaneous fistulas (ECFs) are an uncommon surgical problem, but they are characterized by a difficult management. Vacuum-assisted closure (VAC) therapy is a method utilized for chronic and traumatic wound healing. At first, VAC therapy had been contraindicated in the treatment of intestinal fistulas, but as time went by, VAC therapy revealed itself to be a "Swiss knife multi-tool". This paper presents some clinical cases of enterocutaneous (ECF) and enteroatmospheric fistulas (EAF) treated with VAC therapy T.
   MATERIALS AND METHODS: The history of 8 patients treated for complex fistulas was revised. Four of them presented with enterocutaneous and four with enteroatmospheric fistulas. All were treated with VAC therapy with variations elaborated to help in accelerated closure of intestinal wall lesions.
   RESULTS: Four out of four ECFs closed spontaneously. In the EAF group, in three cases the fistula turned slowly into an entero-cutaneous fistula, and in one out of four it closed spontaneously. The mean length of VAC therapy T was 35.5 days and that of spontaneous closure was 36.4 days.
   CONCLUSIONS: The results of our study encourage the use of VAC therapy T for the treatment of enterocutaneous fistulas. VAC therapy T use has a double therapeutic value: (1) it promotes the healing of the skin and allows also the management of EAFs; (2) in selected cases, those in which it is possible to create a deep fistula tract ("well") it is possible to assist to a complete healing with closure of the ECFs.
C1 [Pepe, G.; Magalini, S.; Lodoli, C.; Gui, D.] Univ Cattolica Sacro Cuore, Gemelli Polyclin, Dept Surg, Emergency Surg Unit, I-00168 Rome, Italy.
   [Callari, C.] Univ Cattolica Sacro Cuore, Gemelli Polyclin, Dept Surg, Endocrine & Metab Surg Unit, I-00168 Rome, Italy.
   [Persiani, R.] Univ Cattolica Sacro Cuore, Gemelli Polyclin, Dept Surg, Gen Surg Unit, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Pepe, G (通讯作者)，Univ Cattolica Sacro Cuore, Gemelli Polyclin, Dept Surg, Emergency Surg Unit, I-00168 Rome, Italy.
EM gildapepe@yahoo.it
RI Persiani, Roberto/AAC-2077-2022
OI Persiani, Roberto/0000-0001-5584-6095
CR [Anonymous], WORLD J SURG ONCOL
   Banasiewicz T, 2011, VIDEOSURGERY MINIINV, V6, P155, DOI 10.5114/wiitm.2011.24694
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NR 21
TC 20
Z9 23
U1 0
U2 2
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD SEP
PY 2014
VL 18
IS 17
BP 2527
EP 2532
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CF0AA
UT WOS:000352203700021
PM 25268100
DA 2026-07-24
ER
PT J
AU Lee, HJ
   Lee, H
AF Lee, Hyun Jik
   Lee, Hyuk
TI Endoscopic Vacuum-assisted Closure With Sponge for Esophagotracheal
   Fistula After Esophagectomy
SO SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
LA English
DT Article
DE endoscopic vacuum-assisted closure with sponge; esophagotracheal
   fistula; esophagectomy
ID INTESTINAL ANASTOMOTIC LEAKS; EXPERIENCE; MANAGEMENT; SURGERY
AB We experienced a case of endoscopic vacuum-assisted closure with sponge for esophagotracheal fistula diagnosed after esophagectomy due to squamous cell esophageal cancer. The patient, who had undergone a robotic-assisted thoracoscopic esophagectomy and esophageal reconstruction of the stomach, was referred for the management of esophagotracheal fistula. Diagnostic esophagogastroduodenoscopy and imaging studies were performed, and they indicated anastomotic leakage with esophagotracheal fistula. The patient was treated by the endoscopic placement of full-covered self-expanding metal stents, but the fistula persisted. Then, we applied a size-adjusted sponge endoscopically with continuous suction by a vacuum system in the fistula lesion. Complete closure was achieved without any procedure-related complications. After 40 days, symptomatic esophageal stricture was detected and treated successfully with endoscopic balloon dilation. Endoscopic vacuum-assisted closure with a sponge might be an adequate alternative treatment option for esophageal stenting for esophagotracheal fistula after esophagectomy.
C1 [Lee, Hyun Jik] Minimally Invas Image Guided Surg Inst, IHU, Strasbourg, France.
   [Lee, Hyuk] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Gastroenterol, Seoul 135710, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Lee, H (通讯作者)，Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Gastroenterol, 50 Irwon Dong, Seoul 135710, South Korea.
EM leehyuk@skku.edu
CR Babor Richard, 2009, Surg Laparosc Endosc Percutan Tech, V19, pe1, DOI 10.1097/SLE.0b013e318196c706
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NR 9
TC 13
Z9 13
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1530-4515
EI 1534-4908
J9 SURG LAPARO ENDO PER
JI Surg. Laparosc. Endosc. Pct. Tech.
PD APR
PY 2015
VL 25
IS 2
BP E76
EP E77
DI 10.1097/SLE.0000000000000143
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CF0JV
UT WOS:000352230800008
PM 25799256
DA 2026-07-24
ER
PT J
AU Schlatterer, DR
   Hirschfeld, AG
   Webb, LX
AF Schlatterer, Daniel R.
   Hirschfeld, Adam G.
   Webb, Lawrence X.
TI Negative Pressure Wound Therapy in Grade IIIB Tibial Fractures: Fewer
   Infections and Fewer Flap Procedures?
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; SUBATMOSPHERIC PRESSURE;
   MICROSURGICAL RECONSTRUCTION; INTRAMEDULLARY NAILS; TEMPORARY TREATMENT;
   SEALING-TECHNIQUE; MANAGEMENT; COVERAGE; SHAFT
AB Grade IIIB open tibia fractures are devastating injuries. Some clinicians advocate wound closure or stable muscle flap coverage within 72 hours to limit complications such as infection. Negative pressure wound therapy was approved by the FDA in 1997 and has become an adjunct for many surgeons in treating these fractures. Opinions vary regarding the extent to which negative pressure wound therapy contributes to limb salvage. Evidence-based practice guidelines are limited for use of negative pressure wound therapy in Grade IIIB tibia fractures. This systematic literature review of negative pressure wound therapy in Grade IIIB tibia fractures may substantiate current use and guide future studies.
   We sought to answer the following: (1) Does the use of negative pressure would therapy compared with gauze dressings lead to fewer infections? (2) Does it allow flap procedures to be performed safely beyond 72 hours without increased infection rates? (3) Is it associated with fewer local or free flap procedures?
   We conducted a systematic review of six large databases (through September 1, 2013) for studies reporting use of negative pressure wound therapy in Grade IIIB open tibia fractures, including information regarding infection rates and soft tissue reconstruction. The systematic review identified one randomized controlled trial and 12 retrospective studies: four studies compared infection rates between negative pressure wound therapy and gauze dressings, 10 addressed infection rates with extended use, and six reported on flap coverage rates in relation to negative pressure wound therapy use beyond 72 hours. None of the 13 studies was eliminated owing to lack of study quality.
   Negative pressure wound therapy showed a decrease in infection rates over rates for gauze dressings in two of four studies (5.4% [two of 35] versus 28% [seven of 25], and 8.4% [14 of 166] versus 20.6% [13 of 63]), an equivalent infection rate in one study (15% [eight of 53] versus 14% [five of 16]), and an increased infection rate in the fourth study (29.5% [23 of 78] versus 8% [two of 25]). In terms of the second question regarding infection rates with negative pressure wound therapy beyond 72 hours, eight of 10 studies concluded there was no increase in infection rates, whereas two of 10 reported an increase in infection rates associated with negative pressure wound therapy use beyond 72 hours. Infection rates varied from 0% to 57% in these 10 studies. Five studies reported low infection rates of 0% to 7% and five reported rates of 27% to 57%. The third question (addressed by six studies) regarded the potential decreased use of a soft tissue flap in patients treated with extended negative pressure wound therapy. Flap rates were reduced by 13% to 60% respectively compared with those of historical controls. Grade IIIB tibia fractures by definition required soft tissue procedures. The patients in these six studies had Grade IIIB tibia fractures after the first d,bridement. However, after extended negative pressure wound therapy, fewer patients required flaps than grading at the first d,bridement would have predicted.
   There is an increasing body of data supporting negative pressure wound therapy as an adjunctive modality at all stages of treatment for Grade IIIB tibia fractures. There is an association between decreased infection rates with negative pressure wound therapy compared with gauze dressings. There is evidence to support negative pressure wound therapy beyond 72 hours without increased infection rates and to support a reduction in flap rates with negative pressure wound therapy. However, negative pressure wound therapy use for Grade IIIB tibia fractures requires extensive additional study.
   Level III, therapeutic study.
C1 [Schlatterer, Daniel R.] Atlanta Med Ctr, Orthopaed Trauma, Atlanta, GA 30312 USA.
   [Hirschfeld, Adam G.] Atlanta Med Ctr, Orthopaed Surg, Atlanta, GA 30312 USA.
   [Webb, Lawrence X.] Cent GA Orthoped Trauma Inst, Macon, GA USA.
C3 WellStar Atlanta Medical Center; WellStar Atlanta Medical Center
RP Schlatterer, DR (通讯作者)，Atlanta Med Ctr, Orthopaed Trauma, 303 Pkwy Dr NE, Atlanta, GA 30312 USA.
EM danschlatterer@yahoo.com
OI Hirschfeld, Adam/0009-0003-7372-7235
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NR 55
TC 63
Z9 78
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-921X
EI 1528-1132
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD MAY
PY 2015
VL 473
IS 5
BP 1802
EP 1811
DI 10.1007/s11999-015-4140-1
PG 10
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA CF1CB
UT WOS:000352280100043
PM 25595096
OA Bronze
DA 2026-07-24
ER
PT J
AU Ellenrieder, M
   Redanz, S
   Bader, R
   Mittelmeier, W
   Podbielski, A
AF Ellenrieder, Martin
   Redanz, Sylvio
   Bader, Rainer
   Mittelmeier, Wolfram
   Podbielski, Andreas
TI Influence of Antimicrobial Coatings of Vacuum-Assisted Closure Dressings
   on Methicillin-Resistant Staphylococcus aureus Growth Kinetics:
   An In Vitro Study
SO SURGICAL INFECTIONS
LA English
DT Article
ID NEGATIVE-PRESSURE; WOUND THERAPY; SILVER; ANTIBACTERIAL; PREVENTION;
   ULCERS; VIVO
AB Background: Silver-containing negative-pressure wound therapy (NPWT) foam dressings should reduce the microbial load of infected surgical sites and thereby promote healing. The effects of silver and an experimental copper coating of NPWT dressings on the growth kinetics of methicillin-resistant Staphylococcus aureus (MRSA) were investigated with a focus on the importance of the initial bacterial load and the incubation time.
   Methods: Commercially available foam samples with and without silver coating were inoculated in vitro with six MRSA suspensions differing in bacterial concentration (1.85x10(3) to 1.85x10(8) colony-forming units per milliliter [CFU/mL]). In a second series, uncoated, silver-containing and experimental copper-coated foam samples were inoculated with one MRSA suspension (1.85x10(6) CFU/mL). The MRSA viable counts in the entrapped fluid were evaluated statistically after 1, 3, 7, and 14 d incubation.
   Results: Silver foam samples reduced MRSA counts by two decimal powers compared with the corresponding inocula. With respect to the uncoated samples, silver coating reduced MRSA concentrations by up to 7 logs, which was significant (p <= 0.045) for all groups except the one with the highest MRSA concentration. The antibacterial effect of copper became apparent only after 7 d, but thereafter was far more pronounced than the effects of silver (p<0.01 after 14 d).
   Conclusions: Antimicrobial-coated foam dressings showed significant in vitro antibacterial properties and thus could be advantageous in the treatment of MRSA-infected incisions.
C1 [Ellenrieder, Martin; Bader, Rainer; Mittelmeier, Wolfram] Univ Med Rostock, Dept Orthopaed, D-18055 Rostock, Germany.
   [Redanz, Sylvio; Podbielski, Andreas] Univ Med Rostock, Inst Med Microbiol Virol & Hyg, D-18055 Rostock, Germany.
C3 University of Rostock; University of Rostock
RP Ellenrieder, M (通讯作者)，Univ Med Rostock, Dept Orthopaed, Doberaner Str 142, D-18055 Rostock, Germany.
EM martin.ellenrieder@uni-rostock.de
RI Redanz, Sylvio/AAH-1369-2020; Ellenrieder, Martin/JQJ-5155-2023
OI Redanz, Sylvio/0000-0003-1541-2545; 
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NR 35
TC 9
Z9 10
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD APR 1
PY 2015
VL 16
IS 2
BP 139
EP 145
DI 10.1089/sur.2013.268
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA CF2EN
UT WOS:000352360400004
PM 25658621
DA 2026-07-24
ER
PT J
AU Hickson, E
   Harris, J
   Brett, D
AF Hickson, Evelyn
   Harris, Jeanette
   Brett, David
TI A Journey to Zero: Reduction of Post-Operative Cesarean Surgical Site
   Infections over a Five-Year Period
SO SURGICAL INFECTIONS
LA English
DT Article
ID PRESSURE WOUND THERAPY; MANAGEMENT
AB Background: Surgical site infections (SSI) are a substantial concern for cesarean deliveries in which a surgical site complication is most unwelcome for a mother with a new infant. Steps taken pre- and post-operatively to reduce the number of complications may be of substantial benefit clinically, economically, and psychologically.
   Methods: A risk-based approach to incision management was developed and implemented for all cesarean deliveries at our institution. A number of incremental interventions for low-risk and high-risk patients including pre-operative skin preparations, standardized pre- and post-operative protocols, post-operative nanocrystalline silver anti-microbial barrier dressings, and incisional negative pressure wound therapy (NPWT) were implemented sequentially over a 5-y period. A systematic clinical chart review of 4,942 patients spanning all cesarean deliveries between 2007-2012 was performed to determine what effects the interventions had on the rate of SSI for cesarean deliveries.
   Results: The percentage of SSI was reduced from 2.13% (2007) to 0.10% (2012) (p<0.0001). There were no substantial changes in the patient population risk factors over this time. As a result of the changes in incision management practice, a total of 92 cesarean post-operative SSIs were avoided: A total cost saving of nearly $5,000,000.
   Conclusion: Applying a clinical algorithm for assessing the risk of surgical site complication and making recommendations on pre-operative and post-operative incision management can result in a substantial and sustainable reduction in cesarean SSI.
C1 [Hickson, Evelyn] MultiCare Hlth Syst, Puyallup, WA USA.
   [Harris, Jeanette] MultiCare Hlth Syst, Infect Prevent, Puyallup, WA USA.
   [Brett, David] Smith & Nephew Wound Management Div, St Petersburg, FL 33701 USA.
C3 Smith & Nephew
RP Brett, D (通讯作者)，Smith & Nephew Wound Management Div, St Petersburg, FL 33701 USA.
EM dave.brett@smith-nephew.com
OI Harris, Jeanette/0000-0002-9871-2764
FU Smith Nephew
FX E.H. has acted as a consultant for a fee and been paid or sponsored by
   the organization (Smith & Nephew) to speak to professional or lay
   groups. J.H. has been paid or sponsored by the organization (Smith &
   Nephew) to speak to professional or lay groups. D.B. is an employee and
   a shareholder of Smith & Nephew, Inc.
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NR 15
TC 24
Z9 25
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD APR 1
PY 2015
VL 16
IS 2
BP 174
EP 177
DI 10.1089/sur.2014.145
PG 4
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA CF2EN
UT WOS:000352360400011
PM 25826622
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Said, SM
   Daly, RC
AF Said, Sameh M.
   Daly, Richard C.
TI Healing High-Risk Sternotomy Incisions: Interrupted Suture Closure and
   Negative Pressure Wound Therapy
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID INFECTIONS; MANAGEMENT
AB High-risk sternotomy incisions represent a challenge at the time of wound closure. We present an alternate wound closure technique that can be used in high-risk sternotomy incisions and consists of a combination of space-obliterating sutures and negative pressure (suction using wound VAC) therapy. doi: 10.1111/jocs.12388 (J Card Surg 2015;30:346-350)
C1 [Said, Sameh M.; Daly, Richard C.] Mayo Clin, Div Cardiovasc Surg, Rochester, MN USA.
C3 Mayo Clinic
RP Daly, RC (通讯作者)，200 First St,SW, Rochester, MN 55905 USA.
EM rdaly@mayo.edu
RI Said, Sameh/GPX-2127-2022
OI Said, Sameh/0000-0003-2193-0314
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NR 10
TC 2
Z9 2
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD APR
PY 2015
VL 30
IS 4
BP 346
EP 350
DI 10.1111/jocs.12388
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA CF4BV
UT WOS:000352494400008
PM 24943468
DA 2026-07-24
ER
PT J
AU Aydin, S
   Aydin, ÇA
   Ugurlucan, FG
   Yasa, C
   Dural, Ö
AF Aydin, Serdar
   Aydin, Cagri Arioglu
   Ugurlucan, Funda Gungor
   Yasa, Cenk
   Dural, Ozlem
TI Recurrent pyoderma gangrenosum after cesarean delivery successfully
   treated with vacuum-assisted closure and split thickness skin graft: A
   case report
SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
LA English
DT Article
DE cesarean delivery; pregnancy; pyoderma gangrenosum; split thickness skin
   graft; vacuum-assisted closure
ID WOUND CONTROL; SURGERY; THERAPY
AB We describe the case of a 32-year-old woman (gravidity: 4; parity: 2) who underwent cesarean delivery at 37 weeks of gestation and presented with dehiscence and infection of the surgical wound. She had a history of wound infection and dehiscence of the scar from a previous cesarean delivery and dehiscence in the dorsal side of her left hand at the site of intravenous catheterization. The patient was initially diagnosed with a skin infection and later with pyoderma gangrenosum. No evidence of any underlying disease was found. The lesions were treated with systemic corticosteroids and azathioprine, but the lesions were unresponsive to treatment. This complicated case of pyoderma gangrenosum after cesarean delivery, which initially mimicked wound infection, was successfully treated with vacuum-assisted closure and split-thickness skin graft. This synergistic approach with vacuum-assisted closure could be an important treatment option for aggressive and slow-healing lesions.
C1 [Aydin, Serdar] Bezmialem Vakif Univ, Dept Obstet & Gynecol, TR-34093 Istanbul, Turkey.
   [Aydin, Serdar; Aydin, Cagri Arioglu; Ugurlucan, Funda Gungor; Yasa, Cenk; Dural, Ozlem] Istanbul Univ Sch Med, Dept Obstet & Gynecol, Istanbul, Turkey.
C3 Bezmialem Vakif University; Istanbul University
RP Aydin, S (通讯作者)，Bezmialem Vakif Univ, Dept Obstet & Gynecol, Adnan Menderes Bulvari, TR-34093 Istanbul, Turkey.
EM serdariks@yahoo.com
RI Ugurlucan, Funda/AAD-3082-2020; Dural, Ozlem/AAY-2248-2020; Yasa,
   Cenk/K-9844-2016; Aydın, Serdar/AAR-9362-2020
OI Yasa, Cenk/0000-0002-7183-1456; Aydın, Serdar/0000-0002-2043-395X
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NR 16
TC 18
Z9 19
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1341-8076
EI 1447-0756
J9 J OBSTET GYNAECOL RE
JI J. Obstet. Gynaecol. Res.
PD APR
PY 2015
VL 41
IS 4
BP 635
EP 639
DI 10.1111/jog.12559
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CF8DV
UT WOS:000352786800022
PM 25370183
DA 2026-07-24
ER
PT J
AU Gage, MJ
   Yoon, RS
   Egol, KA
   Liporace, FA
AF Gage, Mark J.
   Yoon, Richard S.
   Egol, Kenneth A.
   Liporace, Frank A.
TI Uses of Negative Pressure Wound Therapy in Orthopedic Trauma
SO ORTHOPEDIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Negative pressure wound therapy; VAC; Infection; Trauma; Open wound;
   Wound dehiscence; Limb salvage; Open fracture
ID VACUUM-ASSISTED CLOSURE; CLOSED INCISION MANAGEMENT; CONTROLLED-TRIAL;
   COMPLICATIONS; FRACTURES
AB Negative pressure wound therapy (NPWT) is a useful management tool in the treatment of traumatic wounds and high-risk incisions after surgery. Since its development nearly 2 decades ago, uses and indications of NPWT have expanded, allowing its use in a variety of clinical scenarios. In addition to providing a brief summary on its mechanism of action, this article provides a focused, algorithmic approach on the use of NPWT by reviewing the available data, the appropriate clinical scenarios and indications, and the specific strategies that can be used to maximize outcomes.
C1 [Gage, Mark J.; Yoon, Richard S.; Egol, Kenneth A.; Liporace, Frank A.] NYU, Dept Orthopaed Surg, Div Orthopaed Trauma, Hosp Joint Dis, New York, NY USA.
   [Liporace, Frank A.] Jersey City Med Ctr, Orthopaed Trauma & Adult Reconstruct, Dept Orthopaed Surg, Jersey City, NJ 07302 USA.
C3 New York University; NYU Langone Medical Center; Hospital for Joint
   Disease NYULMC
RP Liporace, FA (通讯作者)，NYU, Orthopaed Trauma Res, Div Orthopaed Trauma, Hosp Joint Dis,Dept Orthopaed Surg, New York, NY 10012 USA.
EM liporace33@gmail.com
RI Yoon, Richard/D-2522-2009
OI Yoon, Richard/0000-0001-5240-6633; Gage, Mark/0000-0002-7410-7850
CR Chen Shao-zong, 2005, Zhonghua Zheng Xing Wai Ke Za Zhi, V21, P197
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NR 28
TC 24
Z9 25
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0030-5898
EI 1558-1373
J9 ORTHOP CLIN N AM
JI Orthop. Clin. North Am.
PD APR
PY 2015
VL 46
IS 2
BP 227
EP +
DI 10.1016/j.ocl.2014.11.002
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CF8QI
UT WOS:000352826600007
PM 25771317
DA 2026-07-24
ER
PT J
AU Harding, K
AF Harding, Keith
TI PROLOGUE: TRANSFORMATIONAL HEALING SOLUTIONS
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; instillation therapy; surgical incision
   management; epidermal skin harvesting; wound dressings
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; MULTICENTER; ULCERS;
   STATE
AB In recent years, the provision of wound care for patients has dramatically improved through the development of new therapeutic options, allowing for a wide range of wound care therapy choices. In June 2014, an educational International Surgical Wound Forum (ISWF) was held to present current options in wound care to a multidisciplinary group of healthcare providers. Topics included negative pressure wound therapy with instillation and dwell time (NPWTi-d), surgical incision management (SIM), use of NPWT in the management of the open abdomen, epidermal skin harvesting, and advanced wound dressings. This supplement provides in-depth discussion of some of the topics covered at the 2014 ISWF.
C1 [Harding, Keith] Cardiff Univ, Sch Med, Clin Innovat, Cardiff CF10 3AX, S Glam, Wales.
   [Harding, Keith] Cardiff Univ, Sch Med, WHRU, Cardiff CF10 3AX, S Glam, Wales.
C3 Cardiff University; Cardiff University
RP Harding, K (通讯作者)，Cardiff Univ, Sch Med, Clin Innovat, Cardiff CF10 3AX, S Glam, Wales.
EM HardingKG@cardiff.ac.uk
RI Harding, Keith/J-5605-2013
OI Harding, Keith/0000-0003-0048-3279
FU KCI, an Acelity company
FX KH presented as a faculty member during the 2014 International Surgical
   Wound Forum (ISWF), an annual educational event sponsored by KCI, an
   Acelity company. He is the guest editor for this educational supplement
   based on faculty presentations from the ISWF 2014. Acelity provided
   editorial assistance.
CR [Anonymous], OSTOMY WOUND MANAG S
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NR 12
TC 1
Z9 1
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2015
VL 24
IS 4
SU S
BP 4
EP 5
DI 10.12968/jowc.2015.24.Sup4b.4
PG 2
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CG1YK
UT WOS:000353071900001
PM 25853642
DA 2026-07-24
ER
PT J
AU Wolvos, T
AF Wolvos, Tom
TI THE EVOLUTION OF NEGATIVE PRESSURE WOUND THERAPY: NEGATIVE PRESSURE
   WOUND THERAPY WITH INSTILLATION
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy with instillation; wound healing; dwell
   time; instillation therapy
ID SALINE INSTILLATION; FIBRIN MATRIX; PROLIFERATION; CONJUNCTION; MODEL
AB Complex wounds pose a considerable burden to patients and the health-care system. The development of negative pressure wound therapy (NPWT) has revolutionised the treatment of these wounds. NPWT helps create a favourable wound healing environment by removing infectious material, decreasing oedema and promoting perfusion and granulation tissue formation. Additionally, NPWT has been reported to help reduce time to wound closure and length of hospital stay. Modifications of this foundation of wound care have added intermittent instillation with a dwell time to NPWT (NPWTi-d). This new system offers more comprehensive wound care through automated wound irrigation, allowing more control over the wound environment and the opportunity to deliver topical wound solutions directly to the affected tissues. A comparison between the two therapies, NPWT and NPWTi-d, is described, and two real-world applications of NPWTi-d are presented.
C1 Scottsdale Healthcare Osborn Med Ctr, Gen Surg, Scottsdale, AZ 85251 USA.
C3 Scottsdale Healthcare Osborn
RP Wolvos, T (通讯作者)，Scottsdale Healthcare Osborn Med Ctr, Gen Surg, Scottsdale, AZ 85251 USA.
EM twolvosmd@scottsdalesurgical.com
FU KCI, an Acelity company, Edinburgh, Scotland
FX TW presented as a faculty member during the 2014 International Surgical
   Wound Forum (ISWF), an annual educational event sponsored by KCI, an
   Acelity company, held in 2014 in Edinburgh, Scotland. This article is
   part of a KCI-funded educational supplement based on 2014 ISWF faculty
   presentations about wound-care strategies using negative pressure wound
   therapy. Acelity assisted with the editorial review of the manuscript.
   TW also has a consultant agreement with KCI, an Aecilty company.
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NR 21
TC 21
Z9 29
U1 0
U2 20
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2015
VL 24
IS 4
SU S
BP 15
EP 20
DI 10.12968/jowc.2015.24.Sup4b.15
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CG1YK
UT WOS:000353071900003
PM 25853644
DA 2026-07-24
ER
PT J
AU Horch, RE
AF Horch, Raymund E.
TI INCISIONAL NEGATIVE PRESSURE WOUND THERAPY FOR HIGH-RISK WOUNDS
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE surgical incision management; negative pressure wound therapy; closed
   incision; topical negative pressure therapy; skin circulation; Prevena
   Therapy
ID SURGICAL INCISION; MANAGEMENT-SYSTEM; WEIGHT-LOSS; SURGERY;
   ABDOMINOPLASTY; COMPLICATIONS; PERFUSION; CLOSURES; VACUUM
AB With an ageing population and a growing number of people with obesity and/or undergoing advanced cancer therapies, there is an increasing risk of surgical site complications including surgical site infections (SSIs). Postoperative shifting of large mobilised tissue flaps, such as in abdominoplasties, remains a dreaded complication, particularly following massive weight loss. Besides negative implications for the patient, surgical site complications result in an economic burden due to prolonged and repeated wound treatments. Preventative tools to reduce SSIs are needed. In selected patients at high risk of SSI and/or wound breakdown, use of incisional NPWT has been shown to actively manage clean, closed surgical incisions. This article contains a review of scientific and clinical research relevant to incisional NPWT use over surgical incisions, with particular emphasis on the common problem of wound breakdown and SSI following body-contouring surgery in post-bariatric patients. Although there are a growing number of studies describing use of incisional NPWT in a variety of applications, including vascular, cardiac and orthopaedic, a literature search revealed few studies regarding incisional NPWT use post body-contouring surgery. In a clinical study of seroma formation, less seroma and haematoma formation was reported in post-bariatric patients who received incisional NPWT, versus the control, following body-contouring surgery. In another study of widely applied external NPWT wound dressings over the ventral and lateral trunk following post-bariatric abdominal dermolipectomy, results showed a significant reduction in exudate formation, earlier drain removal, and decreased length of hospitalisation, compared with conventional treatment. Additional controlled studies are needed to validate the clinical impact of incisional NPWT following body-contouring surgery, and to determine proper recommendations for its use.
C1 Univ Erlangen Nurnberg, Univ Hosp Erlangen, Lab Tissue Engn & Regenerat Med, Dept Plast & Hand Surg & Director, Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Univ Hosp Erlangen, Lab Tissue Engn & Regenerat Med, Dept Plast & Hand Surg & Director, Erlangen, Germany.
EM Raymund.Horch@uk-erlangen.de
RI Horch, Raymund/H-8128-2019
FU KCI, an Acelity company
FX REH served as a scientific advisor to KCI, an Acelity company, and
   presented as a faculty member during the 2014 International Surgical
   Wound Forum (ISWF), an annual educational event sponsored by KCI, an
   Acelity company. This article is part of a KCI-funded educational
   supplement based on 2014 ISWF faculty presentations. Acelity provided
   editorial assistance.
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   Baharestani M, 2008, ADV SKIN WOUND CARE, V21, P1
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   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Condé-Green A, 2013, ANN PLAS SURG, V71, P394, DOI 10.1097/SAP.0b013e31824c9073
   Constantine RS, 2014, AESTHET SURG J, V34, P578, DOI 10.1177/1090820X14528208
   de Lissovoy G, 2009, AM J INFECT CONTROL, V37, P387, DOI 10.1016/j.ajic.2008.12.010
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   Dragu A, 2009, OBES SURG, V19, P1599, DOI 10.1007/s11695-008-9559-y
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   Kubek E.W., 2014, MICROBIAL PATHOGENS, P1833
   Leffler M, 2011, J CELL MOL MED, V15, P1564, DOI 10.1111/j.1582-4934.2010.01147.x
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   Mark KS, 2014, SURG INNOV, V21, P345, DOI 10.1177/1553350613503736
   Masden D, 2012, ANN SURG, V255, P1043, DOI 10.1097/SLA.0b013e3182501bae
   Pachowsky M, 2012, INT ORTHOP, V36, P719, DOI 10.1007/s00264-011-1321-8
   Pauli EM, 2013, SURG INFECT, V14, P270, DOI 10.1089/sur.2012.059
   Schmedes GW, 2012, OTOLARYNG HEAD NECK, V147, P1049, DOI 10.1177/0194599812459015
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   Strobel LA, 2014, J TISSUE ENG REGEN M, V8, P176, DOI 10.1002/term.1511
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   Zannis J, 2009, ANN PLAS SURG, V62, P407, DOI 10.1097/SAP.0b013e3181881b29
NR 40
TC 66
Z9 77
U1 2
U2 22
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2015
VL 24
IS 4
SU S
BP 21
EP 28
DI 10.12968/jowc.2015.24.Sup4b.21
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CG1YK
UT WOS:000353071900004
PM 25853645
DA 2026-07-24
ER
PT J
AU Akers, KS
   Rowan, MP
   Niece, KL
   Graybill, JC
   Mende, K
   Chung, KK
   Murray, CK
AF Akers, Kevin S.
   Rowan, Matthew P.
   Niece, Krista L.
   Graybill, John C.
   Mende, Katrin
   Chung, Kevin K.
   Murray, Clinton K.
TI Antifungal wound penetration of amphotericin and voriconazole in
   combat-related injuries: case report
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Invasive fungal infection; Pharmacokinetics; Negative-Pressure Wound
   Therapy; NPWT; Effluent
ID INVASIVE FUNGAL-INFECTIONS; B DEOXYCHOLATE; EXPRESSION; PLASMA;
   PHARMACOKINETICS; EPIDEMIOLOGY; BATTLEFIELD; BIOMARKERS; CYTOKINE;
   REGIMENS
AB Background: Survivors of combat trauma can have long and challenging recoveries, which may be complicated by infection. Invasive fungal infections are a rare but serious complication with limited treatment options. Currently, aggressive surgical debridement is the standard of care, with antifungal agents used adjunctively with uncertain efficacy. Anecdotal evidence suggests that antifungal agents may be ineffective in the absence of surgical debridement, and studies have yet to correlate antifungal concentrations in plasma and wounds.
   Case presentation: Here we report the systemic pharmacokinetics and wound effluent antifungal concentrations of five wounds from two male patients, aged 28 and 30 years old who sustained combat-related blast injuries in southern Afghanistan, with proven or possible invasive fungal infection. Our data demonstrate that while voriconazole sufficiently penetrated the wound resulting in detectable effluent levels, free amphotericin B (unbound to plasma) was not present in wound effluent despite sufficient concentrations in circulating plasma. In addition, considerable between-patient and within-patient variability was observed in antifungal pharmacokinetic parameters.
   Conclusion: These data highlight the need for further studies evaluating wound penetration of commonly used antifungals and the role for therapeutic drug monitoring in providing optimal care for critically ill and injured war fighters.
C1 [Akers, Kevin S.; Rowan, Matthew P.; Niece, Krista L.; Graybill, John C.; Chung, Kevin K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Akers, Kevin S.; Mende, Katrin; Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
   [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
   [Chung, Kevin K.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
C3 Brooke Army Medical Center; Uniformed Services University of the Health
   Sciences - USA; Uniformed Services University of the Health Sciences -
   USA
RP Akers, KS (通讯作者)，US Army, Inst Surg Res, 3698 Chambers Pass,JBSA, Ft Sam Houston, TX 78234 USA.
EM kevin.s.akers.mil@mail.mil
OI Graybill, John Christopher/0000-0001-5823-2566
FU Defense Medical Research & Development Program (DMRDP) Military
   Infectious Disease Clinical Trial Award (MID-CTA)
   [D_MIDCTA_I_12_J2_299]; U.S. Department of Energy; USAMRMC
FX This study was conducted under a protocol reviewed and approved by the
   U.S. Army Medical Research and Materiel Command Institutional Review
   Board and in accordance with approved protocols BAMC C.2013.095 and
   H-09-059. This work was supported by Defense Medical Research &
   Development Program (DMRDP) Military Infectious Disease Clinical Trial
   Award (MID-CTA) #D_MIDCTA_I_12_J2_299, and in part by an appointment to
   the Postgraduate Research Participation Program at the U.S. Army
   Institute of Surgical Research administered by the Oak Ridge Institute
   for Science and Education through an interagency agreement between the
   U.S. Department of Energy and USAMRMC. A portion of this material was
   presented at the 2014 Military Health Systems Research Symposium, Ft.
   Lauderdale FL. We gratefully acknowledge the invaluable contributions of
   Doug Johnson LVN, Kristie Harnisch RN, Crystal Rosemann RN, Charnae
   Williams BS, and the participating research subjects, without whom this
   research would not be possible.
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NR 32
TC 31
Z9 33
U1 1
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD APR 15
PY 2015
VL 15
AR 184
DI 10.1186/s12879-015-0918-8
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA CG3PN
UT WOS:000353192200001
PM 25886578
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Riot, S
   de Bonnecaze, G
   Garrido, I
   Ferron, G
   Grolleau, JL
   Chaput, B
AF Riot, Samuel
   de Bonnecaze, Guillaume
   Garrido, Ignacio
   Ferron, Gwenael
   Grolleau, Jean-Louis
   Chaput, Benoit
TI Is the use of negative pressure wound therapy for a malignant wound
   legitimate in a palliative context? "The concept of NPWT ad
   vitam": A case series
SO PALLIATIVE MEDICINE
LA English
DT Article
DE Palliative wound; case series; negative pressure wound therapy; quality
   of life
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Background: The management of malignant wounds remains particularly difficult. They are often malodorous, highly exuding, and painful. In this context, the use of negative pressure wound therapy is usually not recommended. It is, however, an effective procedure for maintaining a good quality of life in certain palliative situations.
   Case presentation: Five patients underwent negative pressure wound therapy for a malignant wound in our unit. Three had sarcomas, one patient had a parietal recurrence of breast carcinoma, and one patient had melanoma. They were in a metastatic palliative situation and were no longer receiving specific treatment.
   Case management and outcomes: The patients reported a decrease in odor and exudates with negative pressure wound therapy, compared with conventional dressings. No patients complained of pain associated with the suction system itself. Fewer dressing changes reduced the pain and encouraged the resumption of social interactions. The average duration of negative pressure wound therapy before the death of the patients was 49days. No complications or bleeding were observed. The duration of the patients' stay was shortened by implementing negative pressure wound therapy at home.
   Conclusion: We report on our experiences with five patients for whom manufacturers and health authorities contraindicated the use of negative pressure wound therapy because of its potential to encourage tumor growth, although it was considered to be beneficial for all of these patients. This procedure may offer an alternative to conventional wound dressings at the end of life and improve the quality of life of patients by controlling the three most disabling elements: the odor, exudate, and pain associated with changing the dressings. Miniaturization and lower costs could promote the systematic use of negative pressure wound therapy.
C1 [Riot, Samuel; Garrido, Ignacio; Grolleau, Jean-Louis; Chaput, Benoit] Univ Toulouse, CHU Rangueil, Dept Plast & Reconstruct Surg, Toulouse, France.
   [de Bonnecaze, Guillaume; Chaput, Benoit] Univ Toulouse, CHU Rangueil Larrey, Dept Otorhinolaryngol Head & Neck Surg, Toulouse, France.
   [Garrido, Ignacio; Ferron, Gwenael; Chaput, Benoit] Univ Inst Canc, Toulouse, France.
C3 Communaute d'universites et etablissements de Toulouse (Comue);
   Universite de Toulouse (EPE); CHU de Toulouse; Communaute d'universites
   et etablissements de Toulouse (Comue); Universite de Toulouse (EPE); CHU
   de Toulouse
RP Chaput, B (通讯作者)，CHU Rangueil, Dept Plast & Reconstruct Surg, Ave Jean Poulhes, F-31059 Toulouse, France.
EM Benoitchaput31@gmail.com
RI /P-6193-2014
OI CHAPUT, benoit/0000-0002-8567-3479
CR Alvarez OM, 2007, J PALLIAT MED, V10, P1161, DOI 10.1089/jpm.2007.9909
   [Anonymous], NURS STAND
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Benbow M, 1999, Community Nurse, V5, P47
   Ford-Dunn S, 2006, PALLIATIVE MED, V20, P477, DOI 10.1191/0269216306pm1117cr
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NR 8
TC 28
Z9 30
U1 0
U2 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-2163
EI 1477-030X
J9 PALLIATIVE MED
JI Palliat. Med.
PD MAY
PY 2015
VL 29
IS 5
BP 470
EP 473
DI 10.1177/0269216314560009
PG 4
WC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; General & Internal Medicine
GA CG3VZ
UT WOS:000353209000010
PM 25524962
DA 2026-07-24
ER
PT J
AU Tricco, AC
   Antony, J
   Vafaei, A
   Khan, PA
   Harrington, A
   Cogo, E
   Wilson, C
   Perrier, L
   Hui, W
   Straus, SE
AF Tricco, Andrea C.
   Antony, Jesmin
   Vafaei, Afshin
   Khan, Paul A.
   Harrington, Alana
   Cogo, Elise
   Wilson, Charlotte
   Perrier, Laure
   Hui, Wing
   Straus, Sharon E.
TI Seeking effective interventions to treat complex wounds: an overview of
   systematic reviews
SO BMC MEDICINE
LA English
DT Review
DE Complex wound; Effectiveness; Systematic review; Treatment; Ulcer;
   Wounds
ID TOPICAL NEGATIVE-PRESSURE; RANDOMIZED CONTROLLED-TRIALS;
   SILVER-RELEASING DRESSINGS; DIABETIC FOOT ULCERS; VENOUS LEG ULCERS;
   ADJUNCTIVE THERAPY; HYPERBARIC-OXYGEN; SURGICAL WOUNDS; MEASUREMENT
   TOOL; MANAGEMENT
AB Background: Numerous, often multi-faceted regimens are available for treating complex wounds, yet the evidence of these interventions is recondite across the literature. We aimed to identify effective interventions to treat complex wounds through an overview of systematic reviews.
   Methods: MEDLINE (OVID interface, 1946 until October 26, 2012), EMBASE (OVID interface, 1947 until October 26, 2012), and the Cochrane Database of Systematic Reviews (Issue 10 of 12, 2012) were searched on October 26, 2012. Systematic reviews that examined adults receiving care for their complex wounds were included. Two reviewers independently screened the literature, abstracted data, and assessed study quality using the Assessment of Multiple Systematic Reviews (AMSTAR) tool.
   Results: Overall, 99 systematic reviews were included after screening 6,200 titles and abstracts and 422 full-texts; 54 were systematic reviews with a meta-analysis (including data on over 54,000 patients) and 45 were systematic reviews without a meta-analysis. Overall, 44% of included reviews were rated as being of high quality (AMSTAR score >= 8). Based on data from systematic reviews including a meta-analysis with an AMSTAR score >= 8, promising interventions for complex wounds were identified. These included bandages or stockings (multi-layer, high compression) and wound cleansing for venous leg ulcers; four-layer bandages for mixed arterial/venous leg ulcers; biologics, ultrasound, and hydrogel dressings for diabetic leg/foot ulcers; hydrocolloid dressings, electrotherapy, air-fluidized beds, and alternate foam mattresses for pressure ulcers; and silver dressings and ultrasound for unspecified mixed complex wounds. For surgical wound infections, topical negative pressure and vacuum-assisted closure were promising interventions, but this was based on evidence from moderate to low quality systematic reviews.
   Conclusions: Numerous interventions can be utilized for patients with varying types of complex wounds, yet few treatments were consistently effective across all outcomes throughout the literature. Clinicians and patients can use our results to tailor effective treatment according to type of complex wound. Network meta-analysis will be of benefit to decision-makers, as it will permit multiple treatment comparisons and ranking of the effectiveness of all interventions.
C1 [Tricco, Andrea C.; Antony, Jesmin; Vafaei, Afshin; Khan, Paul A.; Harrington, Alana; Cogo, Elise; Wilson, Charlotte; Perrier, Laure; Hui, Wing; Straus, Sharon E.] St Michaels Hosp, Li Ka Shing Knowledge Inst, 209 Victoria St,East Bldg, Toronto, ON M5B 1W8, Canada.
   [Tricco, Andrea C.] Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON M5T 3M7, Canada.
   [Straus, Sharon E.] Univ Toronto, Dept Geriatr Med, Toronto, ON M5S 1A1, Canada.
C3 University of Toronto; Li Ka Shing Knowledge Institute; Saint Michaels
   Hospital Toronto; University of Toronto; University of Toronto
RP Straus, SE (通讯作者)，St Michaels Hosp, Li Ka Shing Knowledge Inst, 209 Victoria St,East Bldg, Toronto, ON M5B 1W8, Canada.
EM sharon.straus@utoronto.ca
RI ; Perrier, Laure/D-4638-2011; Tricco, Andrea/B-9920-2011
OI Cogo, Elise/0000-0003-2480-3652; Vafaei, Afshin/0000-0002-3605-409X;
   Perrier, Laure/0000-0001-9941-7129; Straus, Sharon/0000-0002-6106-832X;
   Khan, Paul/0000-0003-2863-0496; 
FU Toronto Central Local Health Integrated Network; Canadian Institutes for
   Health Research/Drug Safety and Effectiveness Network (CIHR/DSEN); CIHR
FX This project was funded by the Toronto Central Local Health Integrated
   Network. ACT is funded by a Canadian Institutes for Health Research/Drug
   Safety and Effectiveness Network (CIHR/DSEN) New Investigator Award on
   Knowledge Synthesis Methodology. SES is funded by a CIHR tier 1 Research
   Chair in Knowledge Translation.
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NR 125
TC 34
Z9 46
U1 1
U2 72
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD APR 22
PY 2015
VL 13
AR 89
DI 10.1186/s12916-015-0288-5
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CG4MC
UT WOS:000353258900001
PM 25899006
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hu, C
   Zhang, TG
   Ren, B
   Deng, ZM
   Cai, L
   Lei, J
   Ping, AS
AF Hu, Chao
   Zhang, Taogen
   Ren, Bin
   Deng, Zhouming
   Cai, Lin
   Lei, Jun
   Ping, Ansong
TI Effect of Vacuum-Assisted Closure Combined with Open Bone Grafting to
   Promote Rabbit Bone Graft Vascularization
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Bone Regeneration; Bone Transplantation; Negative-Pressure Wound
   Therapy; Transplantation, Homologous
ID PRESSURE WOUND THERAPY; FIBROBLAST GROWTH FACTOR-2; INFECTED TIBIAL
   NONUNION; NEGATIVE-PRESSURE; CHRONIC OSTEOMYELITIS; NON-UNION;
   RECONSTRUCTION; MANAGEMENT; EXCISION; DEFECTS
AB Background: Patients with composite bone non-union and soft tissue defects are difficult to treat. Vacuum-assisted closure (VAC) combined with open bone grafting is one of the most effective treatments at present. The aim of the present study was to preliminarily investigate the effect and mechanism of VAC combined with open bone grafting to promote rabbit bone graft vascularization, and to propose a theoretical basis for clinical work.
   Material/Methods: Twenty-four New Zealand white rabbits were randomly divided into an experimental and a control group. Allogeneic bones were grafted and banded with the proximal femur with a suture. The experimental group had VAC whereas the control group had normal wound closure. The bone vascularization rate was compared based on X-ray imaging, fluorescent bone labeling (labeled tetracycline hydrochloride and calcein), calcium content in the callus, and expression of fibroblast growth factor-2 (FGF-2) in bone allografts by Western blot analysis at the 4th, 8th, and 12th week after surgery.
   Results: At the 4th, 8th, and 12th week after surgery, the results of the tests demonstrated that the callus was larger, contained more calcium (p<0.05), and expressed FGF-2 at higher levels (p<0.05) in the experimental group than in the control group. Fluorescent bone labeling showed the distance between the two fluorescent ribbons was significantly shorter in the control group than in the experimental group at the 8th and 12th week after surgery.
   Conclusions: VAC combined with open bone grafting promoted rabbit bone graft vascularization.
C1 [Hu, Chao; Deng, Zhouming; Cai, Lin; Lei, Jun; Ping, Ansong] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430072, Hubei, Peoples R China.
   [Zhang, Taogen] People Hosp Daye City, Dept Orthoped, Daye, Hubei, Peoples R China.
   [Ren, Bin] Wuhan Univ, Zhongnan Hosp, Dept Radiochemo Therapy, Wuhan 430072, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Cai, L (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430072, Hubei, Peoples R China.
EM guke3559@aliyun.com
RI Ping, An/GRJ-3145-2022; Li, Caiting/ABD-6818-2021
OI Hu, Chao/0000-0001-9093-2642; 
FU Hubei Provincial Natural Science [2014CFA063]
FX The study was funded by the key grant from Hubei Provincial Natural
   Science (No. 2014CFA063)
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NR 41
TC 12
Z9 14
U1 0
U2 8
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD APR 27
PY 2015
VL 21
BP 1200
EP 1206
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CG8DW
UT WOS:000353538400002
PM 25913359
DA 2026-07-24
ER
PT J
AU Gardenbroek, TJ
   Musters, GD
   Buskens, CJ
   Ponsioen, CY
   D'Haens, GRAM
   Dijkgraaf, MGW
   Tanis, PJ
   Bemelman, WA
AF Gardenbroek, T. J.
   Musters, G. D.
   Buskens, C. J.
   Ponsioen, C. Y.
   D'Haens, G. R. A. M.
   Dijkgraaf, M. G. W.
   Tanis, P. J.
   Bemelman, W. A.
TI Early reconstruction of the leaking ileal pouch-anal anastomosis: a
   novel solution to an old problem
SO COLORECTAL DISEASE
LA English
DT Article
DE Ileal pouch-anal anastomosis; inflammatory bowel disease; anastomotic
   leakage; vacuum assisted therapy; Endo-sponge (R)
ID VACUUM-ASSISTED CLOSURE
AB AimThe study aimed to determine the effectiveness and direct medical costs of early surgical closure of the anastomotic defect after a short course of Endo-sponge (R) therapy of the presacral cavity, compared with conventional treatment in patients with anastomotic leakage after ileal pouch-anal anastomosis (IPAA).
   MethodPatients with anastomotic leakage after IPAA undergoing early surgical closure of the anastomotic defect after a short Endo-sponge (R) treatment were prospectively followed and compared with a consecutive cohort of patients with an anastomotic leak treated by creation of a loop ileostomy and occasional drainage of the presacral cavity.
   ResultsA total of 15 patients were treated with early surgical closure and 29 were treated conventionally. In the early surgical closure group, the Endo-sponge (R) treatment was continued for a median of 12days [interquartile range (IQR) 7-15days] with a median of 3 (IQR 2-4) Endo-sponge (R) changes. Secondary anastomotic healing was achieved in all patients (n=15) in the early surgical closure group compared with 52% (n=16) in the conventional treatment group (P=0.003). Closure of the anastomotic defect was achieved after a median of 48 (25-103)days in the early surgical closure group compared with 70 (IQR 49-175)days in the conventional treatment group (P=0.013). A functional pouch was seen in 93% and 86% of the patients in each group. There was no significant difference in direct medical cost.
   ConclusionEarly surgical closure after a short period of Endo-sponge (R) treatment is highly effective in treating anastomotic leakage after IPAA without increasing cost.
C1 [Gardenbroek, T. J.; Musters, G. D.; Buskens, C. J.; Tanis, P. J.; Bemelman, W. A.] Acad Med Ctr, Dept Surg, NL-1100 DD Amsterdam, Netherlands.
   [Gardenbroek, T. J.] Onze Lieve Vrouw Hosp, Dept Surg, Amsterdam, Netherlands.
   [Ponsioen, C. Y.; D'Haens, G. R. A. M.] Acad Med Ctr, Dept Gastroenterol & Hepatol, NL-1100 DD Amsterdam, Netherlands.
   [Dijkgraaf, M. G. W.] Acad Med Ctr, Clin Res Unit, NL-1100 DD Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Onze Lieve
   Vrouwe Gasthuis Hospital; University of Amsterdam; Academic Medical
   Center Amsterdam; University of Amsterdam; Academic Medical Center
   Amsterdam
RP Bemelman, WA (通讯作者)，Acad Med Ctr, Dept Surg, POB 22660, NL-1100 DD Amsterdam, Netherlands.
EM w.a.bemelman@amc.uva.nl
RI Bemelman, Wilhelmus/AAA-1635-2021; Dijkgraaf, Marcel/G-6663-2011; Tanis,
   Pieter/U-2827-2019
OI Tanis, Pieter/0000-0002-3146-3310
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NR 15
TC 51
Z9 53
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD MAY
PY 2015
VL 17
IS 5
BP 426
EP 432
DI 10.1111/codi.12867
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA CG8NO
UT WOS:000353565100016
PM 25512241
OA Green Accepted, Bronze
DA 2026-07-24
ER
PT J
AU Simon, K
   Schulz-Drost, M
   Besendörfer, M
   Carbon, RT
   Schulz-Drost, S
AF Simon, K.
   Schulz-Drost, M.
   Besendoerfer, M.
   Carbon, R. T.
   Schulz-Drost, S.
TI Use of Negative Pressure Wound Therapy on Surgical Incisions (Prevena™)
   after Surgery of Pectus Deformities Reduces Wound Complications
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE pectus repair surgery; preventive negative pressure wound therapy;
   Prevena (TM); postoperative wound healing disorder; wound infection; VAC
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS;
   MANAGEMENT-SYSTEM; CARDIAC-SURGERY; RISK-FACTORS; STERNOTOMY; INFECTION;
   PREVENTION; EXPERIENCE; SURVIVAL
AB Introduction: Pectus surgery can lead to postoperative wound complications in some cases. The purpose of this study is to determine whether preventive negative pressure wound therapy (NPWT) could reduce wound complications after open pectus surgery.
   Material and Methods: 100 patients after open procedure for the treatment of pectus excavatum or pectus carinatum in the years 2010 to 2012 were retrospectively analysed. 50 patients treated with Prevena (TM) (KCI Medical Products GmbH, Wiesbaden, Germany) were compared with 50 patients whose wounds were covered with OPSITE (R) film (Smith & Nephew, Hamburg, Germany). Wound closure was performed following a standard procedure as well as the placement of subcutaneous drains. Therefore two comparable groups of patients were formed and analysed by standardised parameters. The wound dressing was placed epicutaneously immediately after wound closure in the operating room and removed after 5 days in each case. Follow-ups were performed immediately after removal of the wound dressing, at the time of discharge from hospital as well as 6 and 12 weeks after operation. The wounds were checked for tenderness, pain, secretion, redness and fistulas.
   Results: The Prevena group showed 10% wound complications which needed operative treatment, whereas the OPSITE group showed complications in 24%. Some patients who were treated with Prevena showed superficial skin lesions at the rim of the foam and the film. All of these lesions healed well.
   Conclusion: Treating wounds postoperatively with preventive measures (NPWT) showed a remarkable reduction of wound complications following open pectus surgery whereas statistically the difference was not significant (p = 0.074).
C1 [Simon, K.; Besendoerfer, M.; Carbon, R. T.; Schulz-Drost, S.] Univ Klinikum Erlangen, Kinderchirurg Abt, D-91054 Erlangen, Germany.
   [Schulz-Drost, M.] Univ Klinikum Erlangen, Arztliche DRG Koordinat, D-91054 Erlangen, Germany.
   [Schulz-Drost, S.] Univ Klinikum Erlangen, Unfallchirurg Abt, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   University of Erlangen Nuremberg
RP Schulz-Drost, S (通讯作者)，Univ Klinikum Erlangen, Kinderchirurg Abt, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM stefan.schulz-drost@uk-erlangen.de
OI Besendörfer, Manuel/0000-0001-8679-4646
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NR 28
TC 5
Z9 5
U1 0
U2 12
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2015
VL 140
IS 2
BP 156
EP 162
DI 10.1055/s-0033-1360291
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CG8UQ
UT WOS:000353590100010
PM 24647815
DA 2026-07-24
ER
PT J
AU Tuffaha, HW
   Gillespie, BM
   Chaboyer, W
   Gordon, LG
   Scuffham, PA
AF Tuffaha, Haitham W.
   Gillespie, Brigid M.
   Chaboyer, Wendy
   Gordon, Louisa G.
   Scuffham, Paul A.
TI Cost-utility analysis of negative pressure wound therapy in high-risk
   cesarean section wounds
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Cost-effectiveness; Negative pressure wound therapy; Cesarean section;
   Value of information
ID SURGICAL-SITE INFECTIONS; INFORMATION ANALYSIS; HEALTH-CARE;
   DECISION-MAKING; RESEARCH DESIGN; EXPECTED VALUE; TRIAL DESIGN; OBESITY;
   IMPACT; WOMEN
AB Background: Obese women undergoing cesarean section are at increased risk of postoperative infection. There is growing interest in negative pressure wound therapy (NPWT) to prevent closed surgical incision complications including surgical site infection; however, the evidence on the effectiveness and cost-effectiveness of this technology is limited. The objective of this study was to evaluate the cost-effectiveness of NPWT compared with that of standard dressing in preventing surgical site infection in obese women undergoing elective cesarean section based on current evidence and to estimate the value and optimal design of additional research to study this technology.
   Methods: The analysis was from the perspective of Queensland Health, Australia, using a decision model. Parameters were obtained from the published literature, a pilot clinical trial, and expert opinion. Monte Carlo simulation was performed to calculate the net monetary benefit, characterize decision uncertainty, and estimate the value of additional research. Comparing the expected monetary benefits and costs of alternative trial sample sizes informed the optimal future study design.
   Results: The incremental net monetary benefit of NPWTwas Australian dollars 70, indicating that NPWT is cost-effective compared with that of standard dressing. The probability of NPWT being cost-effective was 65%. The estimated value of additional research to resolve decision uncertainty would be Australian dollars 2.7 million. The optimal sample size of a future trial investigating the relative effectiveness of NPWT would be 200 patients per arm.
   Conclusions: Based on the current evidence, NPWT is cost-effective; however, there is high uncertainty surrounding the decision to adopt this technology. Additional research is worthwhile before implementation. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Tuffaha, Haitham W.; Gillespie, Brigid M.; Chaboyer, Wendy; Gordon, Louisa G.; Scuffham, Paul A.] Griffith Univ, Griffith Hlth Inst, Gold Coast, Qld, Australia.
   [Tuffaha, Haitham W.; Gordon, Louisa G.; Scuffham, Paul A.] Griffith Univ, Sch Med, Ctr Appl Hlth Econ, Meadowbrook, Qld 4131, Australia.
   [Tuffaha, Haitham W.; Gillespie, Brigid M.; Chaboyer, Wendy] Griffith Univ, Res Ctr Hlth Practice Innovat, CNHMRC Ctr Res Excellence Nursing Intervent Hospi, Gold Coast, Qld, Australia.
C3 Griffith University; Menzies Health Institute Queensland; Griffith
   University; Griffith University
RP Tuffaha, HW (通讯作者)，Griffith Univ, Griffith Hlth Inst, Sch Med, Ctr Appl Hlth Econ, Meadowbrook, Qld 4131, Australia.
EM haitham.tuffaha@griffith.edu.au
RI Chaboyer, Wendy/F-9588-2018; Gillespie, Brigid/E-7799-2012; Scuffham,
   Paul/B-3066-2014; Tuffaha, Haitham/P-2676-2016; Collins,
   Louisa/P-1427-2016
OI Chaboyer, Wendy/0000-0001-9528-7814; Gillespie,
   Brigid/0000-0003-3186-5691; Scuffham, Paul/0000-0001-5931-642X; Tuffaha,
   Haitham/0000-0003-2993-3480; Collins, Louisa/0000-0002-3159-4249
FU National Health and Medical Research Council PhD scholarship through the
   Centre for Research Excellence in Nursing Interventions for Hospitalised
   Patients
FX H.W.T. is supported by a National Health and Medical Research Council
   PhD scholarship through the Centre for Research Excellence in Nursing
   Interventions for Hospitalised Patients.
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NR 60
TC 43
Z9 45
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAY 15
PY 2015
VL 195
IS 2
BP 612
EP 622
DI 10.1016/j.jss.2015.02.008
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Surgery
GA CG9QH
UT WOS:000353651600028
PM 25796106
DA 2026-07-24
ER
PT J
AU Ninan, N
   Thomas, S
   Grohens, Y
AF Ninan, Neethu
   Thomas, Sabu
   Grohens, Yves
TI Wound healing in urology
SO ADVANCED DRUG DELIVERY REVIEWS
LA English
DT Review
DE Urology; Growth factors; Stem cells; siRNA; Laser tissue welding;
   Negative pressure wound therapy
ID MESENCHYMAL STEM-CELLS; HYPERBARIC-OXYGEN THERAPY; GROWTH-FACTORS;
   FIBRIN SEALANT; IN-VITRO; BOTULINUM-TOXIN; URETERAL INJURY; BLADDER;
   GENE; CYSTITIS
AB Wound healing is a dynamic and complex phenomenon of replacing devitalized tissues in the body. Urethral healing takes place in four phases namely inflammation, proliferation, maturation and remodelling, similar to dermal healing. However, the duration of each phase of wound healing in urology is extended for a longer period when compared to that of dermatology. An ideal wound dressing material removes exudate, creates a moist environment, offers protection from foreign substances and promotes tissue regeneration. A single wound dressing material shall not be sufficient to treat all kinds of wounds as each wound is distinct. This review includes the recent attempts to explore the hidden potential of growth factors, stem cells, siRNA, miRNA and drugs for promoting wound healing in urology. The review also discusses the different technologies used in hospitals to treat wounds in urology, which make use of innovative biomaterials synthesised in regenerative medicines like hydrogels, hydrocolloids, foams, films etc., incorporated with growth factors, drug molecules or nanopartides. These include surgical zippers, laser tissue welding, negative pressure wound therapy, and hyperbaric oxygen treatment (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ninan, Neethu; Grohens, Yves] Univ Bretagne Sud, Lab Ingn Mat Bretagne, F-56321 Lorient, France.
   [Ninan, Neethu; Thomas, Sabu] Mahatma Gandhi Univ, Ctr Nanosci & Nanotechnol, Kottayam 686560, Kerala, India.
C3 Mahatma Gandhi University, Kerala
RP Ninan, N (通讯作者)，Univ Bretagne Sud, Lab Ingn Mat Bretagne LIMatB, Ctr Rech Christiaan Huygens, Rue St Maude,BP 92116, F-56321 Lorient, France.
EM neethuninan85@yahoo.co.in
RI Ninan, Neethu/G-6281-2015; thomas, sabu/G-7310-2016
OI Ninan, Neethu/0000-0002-4469-5954; thomas, sabu/0000-0003-4726-5746
FU Brittany region; European Union (FEDER); French Ministry for research
FX We are thankful to Brittany region, The European Union (FEDER) and the
   French Ministry for research, for supporting this work.
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NR 105
TC 39
Z9 47
U1 1
U2 66
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-409X
EI 1872-8294
J9 ADV DRUG DELIVER REV
JI Adv. Drug Deliv. Rev.
PD MAR
PY 2015
VL 82-83
BP 93
EP 105
DI 10.1016/j.addr.2014.12.002
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CH0UF
UT WOS:000353737200012
PM 25500273
DA 2026-07-24
ER
PT J
AU Bayne, D
   Martin, N
AF Bayne, Duncan
   Martin, Niall
TI A Simple Method to Prevent Vacuum-Assisted Closure Sponge Retention in
   Cavity Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE foam retention; vacuum-assisted wound closure
ID THERAPY
AB While few procedures are complication free, the safety profile of vacuum-assisted closure therapy for wounds has been good. Although rarely reported in the literature, the retention of foam in wounds following this therapy has caused complications. The authors present a technique to prevent foam retention and reduce wound morbidity due to tissue regrowth.
C1 [Bayne, Duncan] Royal Hosp Haslar, Dept Plast Surg, Haslar, Hants, England.
   [Martin, Niall] Minist Def, London, England.
RP Bayne, D (通讯作者)，Queen Victoria Hosp Fdn Trust, Dept Plast Surg, Holtye Rd, E Grinstead RH19 3DZ, W Sussex, England.
EM paperscorrespondence@inbox.com
CR Cravero L, 2006, J PLAST RECONSTR AES, V59, P1250, DOI 10.1016/j.bjps.2006.01.038
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   U.S. FDA, 2022, Manufacturer and User Facility Device Experience
NR 5
TC 1
Z9 1
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2014
VL 26
IS 7
BP E53
EP E54
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CH1XM
UT WOS:000353816500001
DA 2026-07-24
ER
PT J
AU Anglim, B
   O'Connor, H
   Daly, S
AF Anglim, B.
   O'Connor, H.
   Daly, S.
TI Prevena™, negative pressure wound therapy applied to closed Pfannenstiel
   incisions at time of caesarean section in patients deemed at high risk
   for wound infection
SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Article
DE High-risk pregnancy; obesity in pregnancy; Prevena (TM) negative
   pressure wound therapy; wound infection
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT-SYSTEM; PREVENTION; EXPERIENCE;
   DELIVERY; SURGERY
AB The aim of our retrospective study is to report on our experience using the Prevena (TM) wound system in obese patients undergoing caesarean section delivery. A total of 26 cases were identified from July 2012 to October 2013. The median BMI of these women was 45.3 kg/m(2). Elective caesarean sections were performed in 20 women (77%). There were four cases (15%) of superficial dehiscence. Factors associated with wound breakdown were wound infection (p = 0.03), increasing BMI (p = 0.001) and emergency LSCS (p = 0.04). In a logistic regression model the presence of infection was the only factor which remained associated with wound breakdown. Wound disruption is a major cause of morbidity following caesarean section in morbidly obese patients. The wound complication rate in our experience was low with the Prevena (TM) dressing with no cases of sheath dehiscence, and no patient required a second operation. The presence of infection is the most important factor in wound breakdown and should be the focus for management protocols.
C1 [Anglim, B.; O'Connor, H.; Daly, S.] Coombe Women & Infants Univ Hosp, Dept Obstet & Gynaecol, Dublin 8, Ireland.
RP Anglim, B (通讯作者)，Coombe Women & Infants Univ Hosp, Dept Obstet & Gynaecol, Dublin 8, Ireland.
EM breffini.anglim@gmail.com
RI ; O'Connor, Hannah/JBJ-1868-2023
OI Daly, Sean/0009-0001-8450-8113; 
CR Alanis MC, 2010, AM J OBSTET GYNECOL, V203, DOI 10.1016/j.ajog.2010.06.049
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NR 21
TC 17
Z9 20
U1 0
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0144-3615
EI 1364-6893
J9 J OBSTET GYNAECOL
JI J. Obstet. Gynaecol.
PD APR
PY 2015
VL 35
IS 3
BP 255
EP 258
DI 10.3109/01443615.2014.958442
PG 4
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CH3IP
UT WOS:000353924500008
PM 25383909
DA 2026-07-24
ER
PT J
AU Zhou, ZY
   Liu, YK
   Chen, HL
   Liu, F
AF Zhou, Zhen-Yu
   Liu, Ya-Ke
   Chen, Hong-Lin
   Liu, Fan
TI Wound management with vacuum assisted closure in surgical site infection
   after ankle surgery
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Ankle surgery; Surgical site infection; Vacuum assisted closure;
   Standard moist wound care
ID TOPICAL NEGATIVE-PRESSURE; RANDOMIZED CONTROLLED-TRIAL; THERAPY; FOOT;
   MULTICENTER
AB Objective: The aim of this study was to compare the efficacy of vacuum assisted closure (VAC) with standard moist wound care (SMWC) in surgical site infection after ankle surgery.
   Methods: A prospective cohort was performed among patients with surgical site infection after ankle surgery between 2012 and 2013. The follow-up period was three month, and the efficacy end point was complete wound closure rate.
   Results: Ninety-four patients were analyzed, with 61 patients in the VAC group and 33 in the SMWC group. The complete wound closure rate in the VAC group was higher than that in the SMWC group at 3 month follow up (90.2% Vs. 72.7%, p = 0.028). The median time to complete wound closure was 31 days (95% CI 20.2-41.8) for VAC, and 63 days (95% CI 46.9-79.1) for SMWC (chi(2) = 4.023, p = 0.045). In the superficial infection subgroup, the median times to complete wound closure were 20 days (95% CI 14.2-35.1) in the VAC group and 42 days (95% CI 35.4-69.4) in SMWC group (chi(2) = 4.331, p = 0.041). In the deep subgroup, the median times to complete wound closure were 46 days (95% CI 28.2-65.9) in the VAC group and 75 days (95% CI 43.2-79.6) in SMWC group (chi(2) = 6.475, p = 0.026).
   Conclusion: Our result showed that vacuum assisted closure was more effective than standard moist wound care in surgical site infection after ankle surgery. (C) 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.
C1 [Zhou, Zhen-Yu; Liu, Ya-Ke; Liu, Fan] Nantong Univ, Affiliated Hosp, Dept Orthopaed, Nantong, Jiangsu, Peoples R China.
   [Chen, Hong-Lin] Nantong Univ, Nantong City 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University
RP Liu, F (通讯作者)，Nantong Univ, Affiliated Hosp, Dept Orthopaed, Xisi Rd 20, Nantong City 226001, Jiangsu, Peoples R China.
EM pphss@126.com
RI Chen, Hong-Lin/E-5418-2010
OI Liu, Fan/0000-0002-4967-7595
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NR 16
TC 4
Z9 6
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD MAY
PY 2015
VL 17
BP 15
EP 18
DI 10.1016/j.ijsu.2015.03.008
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CH4EQ
UT WOS:000353986200004
PM 25791994
DA 2026-07-24
ER
PT J
AU Yoshino, D
   Sato, K
   Sato, M
AF Yoshino, Daisuke
   Sato, Kakeru
   Sato, Masaaki
TI Endothelial Cell Response Under Hydrostatic Pressure Condition Mimicking
   Pressure Therapy
SO CELLULAR AND MOLECULAR BIOENGINEERING
LA English
DT Article
DE Positive pressure; Negative pressure; Endothelial morphology; Cellular
   area; Cell density; Cell cycle; Proliferation
ID VACUUM-ASSISTED CLOSURE; PROLIFERATION; MORPHOLOGY; MIGRATION; CADHERIN
AB Chronic wounds increase the risk of infection and may lead to complications or disease. Although treatment techniques involving topical negative pressure have been used widely to promote wound healing, the relationship between promotion of wound healing and negative pressure remains unclear. In the present study, we studied the effects of hydrostatic pressure (HP) on endothelial cells (ECs) during pressure treatment. We examined the morphologic and functional responses of ECs to HP using an experimental system developed to apply both negative and positive pressure to ECs. Morphologic parameters such as aspect ratio, orientation angle, and tortuosity did not change after exposure to HP for up to 24 h. In contrast, application of HP led to significant changes in cell area and cell density, and the formation of intercellular gaps was observed as early as 3 h before the cell density reached its peak value. We also found HP progressed EC cycle, which remained at rest according to contact inhibition. Although there were some differences with respect to trends in changes in those parameters, positive and negative pressures had similar effects on ECs. Considering the results of this study, we conclude that exposure to HP enhances the proliferation of ECs.
C1 [Yoshino, Daisuke] Tohoku Univ, Inst Fluid Sci, Aoba Ku, Sendai, Miyagi 9808577, Japan.
   [Sato, Kakeru] Tohoku Univ, Grad Sch Engn, Aoba Ku, Sendai, Miyagi 9808579, Japan.
   [Sato, Masaaki] Tohoku Univ, Frontier Res Inst Interdisciplinary Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan.
   [Sato, Kakeru] Tokyo Gas Co Ltd, Minato Ku, Tokyo 1058527, Japan.
C3 Tohoku University; Tohoku University; Tohoku University; Tokyo Gas Co.,
   Ltd.
RP Yoshino, D (通讯作者)，Tohoku Univ, Inst Fluid Sci, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan.
EM yoshino.d@m.tohoku.ac.jp
RI Yoshino, Daisuke/IXN-3988-2023
OI Yoshino, Daisuke/0000-0002-2948-1210
CR [Anonymous], 2008, COCHRANE DATABASE SY
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NR 25
TC 22
Z9 23
U1 0
U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1865-5025
EI 1865-5033
J9 CELL MOL BIOENG
JI Cell. Mol. Bioeng.
PD JUN
PY 2015
VL 8
IS 2
BP 296
EP 303
DI 10.1007/s12195-015-0385-8
PG 8
WC Cell & Tissue Engineering; Biophysics; Cell Biology; Engineering,
   Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Biophysics; Engineering
GA CH4ET
UT WOS:000353986500007
DA 2026-07-24
ER
PT J
AU Howe, LM
AF Howe, Lisa M.
TI Current Concepts in Negative Pressure Wound Therapy
SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
LA English
DT Article
DE Negative pressure wound therapy (NPWT); Vacuum-assisted closure (VAC);
   Dogs; Cats; Wound care Wounds
ID VACUUM-ASSISTED-CLOSURE; MICROVASCULAR BLOOD-FLOW; OPEN ABDOMEN;
   GENERALIZED PERITONITIS; SEPTIC PERITONITIS; SALINE INSTILLATION;
   BACTERIAL BIOBURDEN; CLOSED WOUNDS; MANAGEMENT; GAUZE
AB Negative pressure wound therapy (NPWT) is becoming recognized in veterinary medicine as a viable option for the management of complex wounds. NPWT has many advantages over traditional wound care and results in quicker and improved wound healing in many instances. This article discusses the art and science of NPWT, as well as the many current indications, complications, advantages and disadvantages, and future directions of NPWT in small animal veterinary medicine. This therapy will likely have a growing role in veterinary medical practice for complicated wound management and other usages in coming years.
C1 Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Small Anim Clin Sci, College Stn, TX 77843 USA.
C3 Texas A&M University System; Texas A&M University College Station
RP Howe, LM (通讯作者)，Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Small Anim Clin Sci, College Stn, TX 77843 USA.
EM lhowe@cvm.tamu.edu
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NR 95
TC 15
Z9 24
U1 2
U2 39
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0195-5616
EI 1878-1306
J9 VET CLIN N AM-SMALL
JI Vet. Clin. N. Am.-Small Anim. Pract.
PD MAY
PY 2015
VL 45
IS 3
BP 565
EP +
DI 10.1016/j.cvsm.2015.01.005
PG 21
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CH7PH
UT WOS:000354228600010
PM 25744142
DA 2026-07-24
ER
PT J
AU Verma, H
   Ktenidis, K
   George, RK
   Tripathi, R
AF Verma, Himanshu
   Ktenidis, Kiriakos
   George, Robbie K.
   Tripathi, Ramesh
TI Vacuum-assisted closure therapy for vascular graft infection (Szilagyi
   grade III) in the groin - a 10-year multi-center experience
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Graft preservation; Sartorious flap; Vacuum therapy; Vascular graft
   infections
ID MUSCLE-FLAP COVERAGE; CONSECUTIVE PATIENT SERIES; MANAGEMENT
AB The aim of the study was to evaluate the benefit of vacuum-assisted closure (VAC) therapy in the management of deep, alloplastic graft infections (Szilagyi grade III) in the groin. From 2000 to 2009, we identified and included in our study 72 deep inguinal infections in 68 patients, involving native as well as synthetic graft or patch material. There were 29 early graft infections (<30 days after implantation) and 43 late infections (30 days after implantation). Among these, 17 cases involved native grafts/patches (12 grafts and 5 patches), while 55 cases involved non-native grafts/patches [26 polytetrafluorethylene (PTFE) grafts and 24 Dacron grafts (Haemashield, Meadox Medical, Boston Scientific Corporation, Natick, NY; Gelsoft graft, Vascutek, Inchinnan, Renfrewshire, Scotland, UK; Intervascular, Mahwah, NJ); INVISTA, and 5 Vascu-Guard bovine pericardial patches; Synovis Surgical Innovation]. All patients were treated with multiple wound debridements, graft salvage, sartorius myoplasty, intravenous antibiotics and VAC therapy until thorough surface healing was achieved. Exclusion criteria were an alloplastic graft infection with proximal expansion above the inguinal ligament, blood culture positive for septicaemia or septic anastomotic herald or overt bleeding. Nine months after initiation of therapy, overall, graft/patch salvage was achieved in 61 of 72 (847%) cases. Of the native graft/patch group, infected graft material was replaced with an autogenous great saphenous vein graft or patch in four patients (235%). In the non-native group, vein or synthetic graft preservation without revision was achieved in 48 of 55 (873%) patients. The mean duration of VAC therapy was 16 +/- 77 days, and postoperative mean hospital stay was 253 +/- 85 days. In 23 of 72 (319%) cases, a secondary closure of the wound was achieved; in the other 49 cases, wound healing was achieved by meshed split-thickness skin grafting. Mean wound healing time for all wounds was 243 +/- 125 days. Specific complications during VAC therapy were wound fluid retention in 2 cases and an increased need for analgesics in 12 cases (1666%). Negative pressure wound therapy (NPWT) has been reported to be useful in the treatment of severe wound infections. Even in the presence of synthetic vascular graft material, NPWT can greatly simplify challenging wound-healing problems leading to wound dehiscence and its sequelae. Our long-term experience demonstrates the safety and effectiveness of VAC therapy in the management of deep graft infections.
C1 [Verma, Himanshu; George, Robbie K.; Tripathi, Ramesh] Narayana Hrudayalaya, Narayana Inst Vasc Sci, Bangalore 560099, Karnataka, India.
   [Ktenidis, Kiriakos] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Dept Vasc Surg, Surg Univ Clin 1, GR-54006 Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; Papageorgiou Hospital
RP Tripathi, R (通讯作者)，Narayana Hrudayalaya, Narayana Inst Vasc Sci, 258-A Bommasandra Ind Area,Hosur Rd, Bangalore 560099, Karnataka, India.
EM ramesh.tripathi@vascularsurgeon.org
RI Tripathi, Ramesh/C-2934-2017
OI Tripathi, Ramesh/0000-0001-7099-1733; George, Robbie/0000-0001-6981-3817
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NR 20
TC 25
Z9 31
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2015
VL 12
IS 3
BP 317
EP 321
DI 10.1111/iwj.12110
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CI1CA
UT WOS:000354476800016
PM 23796163
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hofmann, HS
   Neu, R
   Potzger, T
   Schemm, R
   Grosser, C
   Szöke, T
   Sziklavari, Z
AF Hofmann, Hans-Stefan
   Neu, Reiner
   Potzger, Tobias
   Schemm, Rudolf
   Grosser, Christian
   Szoeke, Tamas
   Sziklavari, Zsolt
TI Minimally Invasive Vacuum-Assisted Closure Therapy With Instillation
   (Mini-VAC-Instill) for Pleural Empyema
SO SURGICAL INNOVATION
LA English
DT Article
DE pleural empyema; VAC-instill; minimally invasive thoracic surgery
AB Enthusiasm for minimally invasive thoracic surgery is increasing. Thoracoscopy plays a significant therapeutic role in the fibrinopurulent stage (stage II) of empyema, in which loculated fluid cannot often be adequately drained by chest tube alone. For some debilitated and septic patients, further procedures such as open-window thoracostomy (OWT) with daily wound care or vacuum-assisted closure (VAC) therapy are necessary. In the present article, we propose a new option of minimally invasive VAC therapy including a topical solution of the empyema without open-window thoracostomy (Mini-VAC-instill). Three patients who underwent surgery using this technique are also presented. The discussion is focused on the advantages and disadvantages of the approach.
C1 [Hofmann, Hans-Stefan; Schemm, Rudolf; Grosser, Christian; Szoeke, Tamas; Sziklavari, Zsolt] Hosp Barmherzige Bruder Regensburg, D-93049 Regensburg, Germany.
   [Neu, Reiner; Potzger, Tobias] Univ Regensburg, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Hofmann, HS (通讯作者)，Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, Prufeningerstr 86, D-93049 Regensburg, Germany.
EM hans-stefan.hofmann@barmherzige-regensburg.de
RI Sziklavari, Zsolt/AGI-2440-2022
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NR 13
TC 10
Z9 15
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD JUN
PY 2015
VL 22
IS 3
BP 235
EP 239
DI 10.1177/1553350614540811
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CI2IE
UT WOS:000354568900003
PM 25049317
DA 2026-07-24
ER
PT J
AU Holt, R
   Murphy, J
AF Holt, Rachel
   Murphy, John
TI PICO™ incision closure in oncoplastic breast surgery: a case series
SO BRITISH JOURNAL OF HOSPITAL MEDICINE
LA English
DT Article
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; RECONSTRUCTION;
   MAMMAPLASTY; MANAGEMENT; MASTECTOMY; IMPACT
AB Single-use negative pressure wound therapy (PICO (TM)) has been used on high-risk surgically incised wounds with encouraging results, but there is no evidence for its use in oncoplastic breast surgery. This article reports a case series with closed incisions in oncoplastic breast procedures following the introduction of PICO (TM).
C1 [Holt, Rachel] Univ Hosp South Manchester NHS Fdn Trust, Plast Surg, Manchester M23 9LT, Lancs, England.
   [Murphy, John] Univ Hosp South Manchester NHS Fdn Trust, Nightingale & Genesis Breast Ctr, Manchester M23 9LT, Lancs, England.
C3 Wythenshawe Hospital NHS Foundation Trust; Wythenshawe Hospital NHS
   Foundation Trust
RP Holt, R (通讯作者)，Univ Hosp South Manchester NHS Fdn Trust, Plast Surg, Manchester M23 9LT, Lancs, England.
EM rachel.holt@uhsm.nhs.uk
CR [Anonymous], 2009, EARL LOC ADV BREAST
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NR 27
TC 23
Z9 25
U1 1
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 1750-8460
EI 1759-7390
J9 BRIT J HOSP MED
JI Br. J. Hosp. Med.
PD APR
PY 2015
VL 76
IS 4
BP 217
EP 223
DI 10.12968/hmed.2015.76.4.217
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CI3TB
UT WOS:000354669200022
PM 25853353
DA 2026-07-24
ER
PT J
AU Rencüzogullari, A
   Dalci, K
   Eray, IC
   Yalav, O
   Okoh, AK
   Akcam, T
   Ülkü, A
   Sakman, G
   Parsak, CP
AF Rencuzogullari, Ahmet
   Dalci, Kubilay
   Eray, Ismail Cem
   Yalav, Orcun
   Okoh, Alexis Kofi
   Akcam, Tolga
   Ulku, Abdullah
   Sakman, Gurhan
   Parsak, Cam P.
TI Comparison of early surgical alternatives in the management of open
   abdomen: a randomized controlled study
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Abdominal compartment syndrome; Bogota bag; intraabdominal hypertension;
   vacuum assisted closure
ID ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL PRESSURE; CLOSURE;
   TRAUMA; DEVICE; SEPSIS
AB BACKGROUND: Abdominal compartment syndrome (ACS) is a clinical syndrome characterized by progressive intraabdominal organ dysfunction resulting from an acute increase in intra-abdominal pressure (IAP). In the absence of prompt treatment, ACS can lead to lethal organ failure. Treatment of ACS is achieved by immediate decompression of the abdominal cavity. As to how and when decompression laparotomy should be performed depends on the clinical condition of the patients. There is limited data regarding outcomes of abdominal closure techiques. The present study aimed to investigate two different temporary closure methods, the vacuum assisted closure (VAC) and Bogota bag techniques, in 40 patients who underwent decompressive laparotomy as part of the management of ACS.
   METHODS: The study included 40 patients who developed ACS during follow-up or following trauma and abdominal surgery. As part of the treatment for ACS, these patients underwent decompressive laparotomy at the Cukurova University Medical Faculty, General Surgery Department and followed up in the Intensive Care Unit of the same hospital. VAC and Bogota bag procedures were performed as temporary closure methods for the treatment of ACS. Patients were randomly assigned to each of the two groups according to the temporary closure method performed. Clinical, laboratory, mortality and morbidity results of the patients in both groups were compared.
   RESULTS: Demographic features of the patients (age, sex, body mass index, co-morbidities) were similar between the two groups. The most common reason of ACS was gastrointestinal perforation in 12 (30%) patients. Decrease in incision width was significantly faster in the VAC group than in the Bogota group. Primary closure of fascia was considered appropriate in 16.9 days in the VAC group and 20.5 days in the Bogota bag group. The decrease in abdominal pressure was similar between the two groups on days 1, 4 and 7 but appeared to be significantly lower on day 14 in the VAC group. 12 patients (30%) died during the study. Among the deceased patients, 5 (12%) were in the VAC group, whereas, 7 (17.5%) belonged to the Bogota bag group.
   CONCLUSION: Based on these results, it is suggested that VAC has advantages when compared to the Bogota bag as a temporary closure method in the management of abdominal compartment syndrome.
C1 [Rencuzogullari, Ahmet; Dalci, Kubilay; Eray, Ismail Cem; Yalav, Orcun; Akcam, Tolga; Ulku, Abdullah; Sakman, Gurhan; Parsak, Cam P.] Cukurova Univ, Fac Med, Dept Gen Surg, Adana, Turkey.
   [Okoh, Alexis Kofi] Ankara Univ, Fac Med, Dept Gen Surg, TR-06100 Ankara, Turkey.
C3 Cukurova University; Ankara University
RP Rencüzogullari, A (通讯作者)，Balcali Hastanesi, TR-01330 Adana, Turkey.
EM rncz1980@gmail.com
RI Dalcı, Kubilay/K-1798-2018; /J-8033-2018; Akcam, Atılgan/K-2237-2018;
   Okoh, Alexis/F-7755-2015
CR [Anonymous], AKTUEL TIP DERGISI
   [Anonymous], CORE TOPICS GEN EMER
   [Anonymous], CRITICAL CARE POSTGR
   [Anonymous], CURR OPIN CRIT CARE
   [Anonymous], COMPLICATIONS SURG
   [Anonymous], EUR J TRAUMA
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   Batacchi S, 2009, CRIT CARE, V13, DOI 10.1186/cc8193
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NR 34
TC 7
Z9 10
U1 0
U2 1
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD MAY
PY 2015
VL 21
IS 3
BP 168
EP 174
DI 10.5505/tjtes.2015.09804
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA CI5DD
UT WOS:000354772200002
PM 26033648
OA Bronze
DA 2026-07-24
ER
PT J
AU Strangio, G
   Zullo, A
   Ferrara, EC
   Anderloni, A
   Carlino, A
   Jovani, M
   Ciscato, C
   Hassan, C
   Repici, A
AF Strangio, Giuseppe
   Zullo, Angelo
   Ferrara, Elisa Chiara
   Anderloni, Andrea
   Carlino, Alessandra
   Jovani, Manol
   Ciscato, Camilla
   Hassan, Cesare
   Repici, Alessandro
TI Endo-sponge therapy for management of anastomotic leakages after
   colorectal surgery: A case series and review of literature
SO DIGESTIVE AND LIVER DISEASE
LA English
DT Article
DE Anastomotic leakage; Colon surgery; Endoscopic treatment; Endo-sponge
ID TOTAL MESORECTAL EXCISION; VACUUM-ASSISTED CLOSURE; RECTAL-CANCER;
   ANTERIOR RESECTION; RISK-FACTORS; DRAINAGE; LEAKS; EXPERIENCE; SINUSES;
   IMPACT
AB Background: Endo-sponge treatment is a novel approach to manage selected patients with anastomotic leakage following colorectal surgery. However, the available data are still scanty.
   Aims: To evaluate the efficacy and safety of the endo-sponge therapy in a large series, and to perform a review of the current evidence concerning such a treatment.
   Methods: Consecutive patients diagnosed with partial colonic anastomotic leakage managed with endo-sponge placement were enrolled. The endo-sponge system was changed every 48-72 h as outpatient, until to cavity closure. Literature review was performed for pooled-data analysis.
   Results: Twenty-five patients were enrolled, including 13 (52%) with diverting ileostomy. Following endo-sponge applications (median sessions: 9, range: 1-39; median treatment duration: 4 weeks, range: 1-32), a complete healing was achieved in 22 (88%) patients. Three (12%) patients developed a major complication (1 uretheric fistula, 1 ileal fistula, and 1 pararectal abscess), all successfully treated by surgery. Ileostomy closure was achieved in 11 (84.6%) patients. No mortality related to the procedure was observed. Overall, 174 patients treated with endo-sponge were reported in literature. By considering data of the larger 7 studies, a complete healing of presacral cavity was achieved in 131 (94.3%) out of 149 patients.
   Conclusions: Our relatively large series of patients confirmed the efficacy, tolerability, and an acceptably low complication rate of endo-sponge therapy for colorectal anastomosis leakage treatment. (C) 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
C1 [Strangio, Giuseppe; Ferrara, Elisa Chiara; Anderloni, Andrea; Carlino, Alessandra; Jovani, Manol; Ciscato, Camilla; Repici, Alessandro] IRCCS Ist Clin Humanitas, Dept Gastroenterol, Milan, Italy.
   [Zullo, Angelo; Hassan, Cesare] Nuovo Regina Margherita Hosp, Gastronterol & Digest Endoscopy, Rome, Italy.
C3 Humanitas University; IRCCS Humanitas Research Hospital; Poliambulatorio
   Nuovo Regina Margherita
RP Zullo, A (通讯作者)，PTP Nuovo Regina Margherita, Gastroenterol Endoscopia Digest, Via E Morosini 30, I-00153 Rome, Italy.
EM angelozullo66@yahoo.it
RI hassan, cesare/H-2844-2012; Zullo, Angelo/AAV-7092-2020; Repici,
   Alessandro/HFH-8162-2022; Anderloni, Andrea/ABE-9139-2020
OI hassan, cesare/0000-0001-7167-1459; Zullo, Angelo/0000-0003-2329-8105;
   Repici, Alessandro/0000-0002-1621-6450; Anderloni,
   Andrea/0000-0002-1021-0031
CR Alves A, 1999, J AM COLL SURGEONS, V189, P554, DOI 10.1016/S1072-7515(99)00207-0
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NR 33
TC 48
Z9 58
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1590-8658
EI 1878-3562
J9 DIGEST LIVER DIS
JI Dig. Liver Dis.
PD JUN
PY 2015
VL 47
IS 6
BP 465
EP 469
DI 10.1016/j.dld.2015.02.007
PG 5
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CI6MY
UT WOS:000354875000007
PM 25769505
DA 2026-07-24
ER
PT J
AU Yoon, BW
   Yi, KI
   Kang, JH
   Kim, SG
   Cha, W
AF Yoon, Byung-Woo
   Yi, Keun-Ik
   Kang, Ji-Hun
   Kim, Soon Gu
   Cha, Wonjae
TI Negative pressure wound therapy for cervical esophageal perforation with
   abscess
SO AURIS NASUS LARYNX
LA English
DT Article
DE Cervical esophageal perforation; Neck; Abscess; Negative pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Perforation of the cervical esophagus is a rare but life-threatening condition. Cervical esophageal perforation with abscess formation can be usually treated with conservative treatments of simple drainage and antibiotics. Aggressive surgical treatments are considered if conservative treatments fail. But the aggressive treatments have low success rate and high morbidity in cervical esophageal perforation. Negative pressure wound therapy (NPWT) was widely used in various complicated wounds, such as diabetic foot ulcers, open abdomen, pressure ulcers, open fractures, sterna wounds, grafts, and flaps since it had been introduced in 1997. NPWT is known to be a valuable tool in the management of various complicated wounds. In this report, we described a case of intractable cervical esophageal perforation with abscess, which was successfully treated with NPWT after the failure of conservative management. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Yoon, Byung-Woo; Yi, Keun-Ik; Kang, Ji-Hun; Kim, Soon Gu; Cha, Wonjae] Pusan Natl Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Busan 602739, South Korea.
   [Cha, Wonjae] Pusan Natl Univ Hosp, Biomed Res Inst, Busan 602739, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital
RP Cha, W (通讯作者)，Pusan Natl Univ Hosp, 179 Gudeok Ro, Busan 602739, South Korea.
EM cha.wonjae@gmail.com
RI ; Cha, Wonjae/AAH-8958-2020
OI Yi, Keun-Ik/0000-0002-7924-5646; Cha, Wonjae/0000-0001-7292-9474
CR Abbas G, 2009, SURGERY, V146, P749, DOI 10.1016/j.surg.2009.06.058
   Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
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   Biancari F, 2013, WORLD J SURG, V37, P1051, DOI 10.1007/s00268-013-1951-7
   Brinster CJ, 2004, ANN THORAC SURG, V77, P1475, DOI 10.1016/j.athoracsur.2003.08.037
   Desai KK, 2012, CLIN PLAST SURG, V39, P311, DOI 10.1016/j.cps.2012.05.002
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
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NR 11
TC 4
Z9 8
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0385-8146
EI 1879-1476
J9 AURIS NASUS LARYNX
JI Auris Nasus Larynx
PD JUN
PY 2015
VL 42
IS 3
BP 254
EP 257
DI 10.1016/j.anl.2014.11.003
PG 4
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA CI8OJ
UT WOS:000355031300015
PM 25510951
DA 2026-07-24
ER
PT J
AU Oguz, A
   Gümüs, M
   Turkoglu, A
   Bozdag, Z
   Ülger, BV
   Agaçayak, E
   Böyük, A
AF Oguz, Abdullah
   Gumus, Metehan
   Turkoglu, Ahmet
   Bozdag, Zubeyir
   Ulger, Burak Veli
   Agacayak, Elif
   Boyuk, Abdullah
TI Fournier's Gangrene: A Summary of 10 Years of Clinical Experience
SO INTERNATIONAL SURGERY
LA English
DT Article
DE Fournier's gangrene; Trephine ostomy; Vacuum-assisted closure; Mortality
ID VACUUM-ASSISTED CLOSURE; SEVERITY INDEX; MANAGEMENT; MORTALITY
AB We aimed to present our clinical experience with FG treatment. Fournier's gangrene (FG) is a rare but serious disease characterized by progressive necrosis in the genitourinary and perineal region. The retrospective study included 43 patients. Patients were divided into 2 groups as survivors and nonsurvivors. Included in the analysis were data pertaining to demographics, predisposing factors, comorbidities, results of bacteriologic analyses, number of debridements, duration of treatment, FG Severity Index (FGSI) score, fecal diversion methods (trephine ostomy or Flexi-Seal Fecal Management System-FMS), and dressing methods (wet or negative aspiration system). In the nonsurvivor group, urea, WBC, and age were significantly higher, whereas albumin, hematocrit, platelet count, and length of hospital stay (LOHS) were significantly lower compared to the survivor group. Mean FGSI was lower in survivors in comparison with nonsurvivors (5.00 +/- 1.86 and 10.00 +/- 1.27, respectively; P < 0.001). We conclude that FGSI is an important predictor in the prognosis of FG. Vacuum-assisted closure (VAC) should be performed in compliant patients in order to enhance patient comfort by reducing pain and the number of dressings. Fecal diversion should be performed as needed, preferably by using FMS. The trephine ostomy should be the method of choice in cases where an ostomy is necessary.
C1 [Oguz, Abdullah; Gumus, Metehan; Turkoglu, Ahmet; Bozdag, Zubeyir; Ulger, Burak Veli; Boyuk, Abdullah] Dicle Univ, Fac Med, Dept Gen Surg, TR-21280 Diyarbakir, Turkey.
   [Agacayak, Elif] Dicle Univ, Fac Med, Dept Obstet & Gynecol B, TR-21280 Diyarbakir, Turkey.
C3 Dicle University; Dicle University
RP Oguz, A (通讯作者)，Dicle Univ, Fac Med, Dept Gen Surg, TR-21280 Diyarbakir, Turkey.
EM dragtiz@hotmail.com
RI /Q-6602-2019
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NR 37
TC 41
Z9 50
U1 0
U2 6
PU INT COLLEGE OF SURGEONS
PI CHICAGO
PA 1516 N LAKE SHORE DR, CHICAGO, IL 60610 USA
SN 0020-8868
J9 INT SURG
JI Int. Surg.
PD MAY
PY 2015
VL 100
IS 5
BP 934
EP 941
DI 10.9738/INTSURG-D-15-00036.1
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CJ0UF
UT WOS:000355193300028
PM 25859652
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Li, XQ
   Liu, JQ
   Liu, Y
   Hu, XL
   Dong, ML
   Wang, HT
   Hu, DH
AF Li, Xiaoqiang
   Liu, Jiaqi
   Liu, Yang
   Hu, Xiaolong
   Dong, Maolong
   Wang, Hongtao
   Hu, Dahai
TI Negative pressure wound therapy accelerates rats diabetic wound by
   promoting agenesis
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Negative pressure wound therapy; diabetic wound; angiogenesis; wound
   healing
ID ENDOTHELIAL GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; OF-THE-LITERATURE;
   MICROVESSEL DENSITY; EXPRESSION; VASCULARIZATION; ANGIOPOIETINS;
   MELLITUS; TUMORS
AB Negative Pressure Wound Therapy (NPWT) has become widely adopted to several wound treatment over the last 15 years, including diabetic foot ulcer (DFU). Much of the existing evidence supports that NPWT increase in blood flow, reduce in edema, decrease bacterial proliferation and accelerate granulation-tissue formation. However, the accurate mechanism is not clear till now. The aim of the present study was to further elucidate the effects of NPWT on angiogenesis of diabetic wound model. As result, our data showed: 1) NPWT promoted the wound healing and blood perfusion on both diabetic and normal wound compared with control, 2) The NPWT increased wound vessel density, and the wound treated with NPWT showed well developed and more functional vessels at day 7 post operation compared with control 3) NPWT up regulated the expression of VEGF at day 3 and Ang1 at day 7 on RNA and protein level. 4) Ang2 was up regulated in diabetic rats but NPWT attenuated this affection. Our data indicated that NPWT increased vessel density and promoted the maturation of neovascular over the potential mechanism of up regulated VEGF and Ang1 and down regulated of Ang2.
C1 [Li, Xiaoqiang; Liu, Jiaqi; Liu, Yang; Hu, Xiaolong; Dong, Maolong; Wang, Hongtao; Hu, Dahai] Fourth Mil Med Univ, Dept Burn & Cutaneous Surg, Burn Ctr PLA, Xijing Hosp, Xian 710032, Peoples R China.
C3 Air Force Medical University
RP Wang, HT (通讯作者)，Fourth Mil Med Univ, Dept Burn & Cutaneous Surg, Burn Ctr PLA, Xijing Hosp, Xian 710032, Peoples R China.
EM wang-ht@fmmu.edu.cn; hudhai@fmmu.edu
RI ; /AFR-6600-2022
OI Hu, Dahai/0000-0001-5543-092X; 
FU Natural Science Foundation of Shaanxi Province of China [2014JM4180]
FX This work was supported by the Natural Science Foundation of Shaanxi
   Province of China (2014JM4180).
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NR 22
TC 33
Z9 37
U1 1
U2 6
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 3
BP 3506
EP 3513
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CJ2IK
UT WOS:000355307300047
PM 26064242
DA 2026-07-24
ER
PT J
AU Monsen, C
   Acosta, S
   Mani, K
   Wann-Hansson, C
AF Monsen, C.
   Acosta, S.
   Mani, K.
   Wann-Hansson, C.
TI A randomised study of NPWT closure versus alginate dressings in
   peri-vascular groin infections: quality of life, pain and cost
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative wound pressure therapy; groin infection; quality of life; pain;
   cost
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; TRIAL; GRAFT
AB Objective: The aim of this study was to compare the vacuum assisted wound closure (VAC) system (negative pressure wound therapy; NPWT) and alginate wound dressings in terms of quality of life (QoL), pain resource use and cost in patients with deep peri-vascular groin infection after vascular surgery.
   Method: Patients with deep peri-vascular groin infection (Szilagyi grade III) were included and randomised to NPWT or alginate therapy. EuroQol 5D (EQ-5D) and brief pain inventory (BPI) were used to evaluate QoL and pain, respectively. l
   Results: Wound healing time until complete skin epithelialisation was shorter in the NPWT (n=9) compared to the alginate group (n=7), median 57 and 104 days, respectively (p=0.026). No difference was recorded in QoL and pain between the groups at study start and the second assessment. QoL analysis within groups between time points, showed that patients in NPWT groups improved in EQ-5D domains, 'self-care' (p= 0.034), 'usual activities' (p=0.046); EQ-5D index value (p=0.046) and EQ-VAS (p=0.028). Patients in the NPWT group reported significantly less pain 'affecting their relations with other people' and 'sleep' between time points. The NPWT group had significantly fewer dressing changes compared to the alginate group (p<0.001). The median frequency of wound dressing changes outside hospital was 20 (IQR 6-29) in the NPWT group (n=9), compared to 48 (IQR 42-77) in the alginate group (n=8; p=0.004). The saved personnel time for wound care in the first week for the NPWT group, compared with the alginate group, was 4.5 hours per week per nurse. The total hospitalised care cost was 83-87% of the total cost in both groups.
   Conclusion: NPWT therapy in patients with deep peri-vascular groin infection can be regarded as the dominant strategy due to improved clinical outcome with equal cost and quality of life measures.
C1 [Monsen, C.; Acosta, S.] Skane Univ Hosp, Vasc Ctr Malmo Lund, Malmo, Sweden.
   [Mani, K.] Univ Uppsala Hosp, Inst Surg Sci, Uppsala, Sweden.
   [Wann-Hansson, C.] Malmo Univ, Dept Care Sci, Malmo, Sweden.
C3 Lund University; Skane University Hospital; Uppsala University; Uppsala
   University Hospital; Malmo University
RP Monsen, C (通讯作者)，Skane Univ Hosp, Vasc Ctr Malmo Lund, Malmo, Sweden.
EM christina.monsen@skane.se
RI Acosta, Stefan/JAX-3225-2023; Kumlien, Christine/ISB-5443-2023; Mani,
   Kevin/MIP-6841-2025
OI Acosta, Stefan/0000-0002-3225-0798; Kumlien,
   Christine/0000-0002-1437-5060; 
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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NR 26
TC 26
Z9 28
U1 0
U2 16
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2015
VL 24
IS 6
BP 252
EP 260
DI 10.12968/jowc.2015.24.6.252
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CJ8PK
UT WOS:000355765400003
PM 26075373
DA 2026-07-24
ER
PT J
AU Matiasek, J
   Djedovic, G
   Unger, L
   Beck, H
   Mattesich, M
   Pierer, G
   Koller, R
   Rieger, UM
AF Matiasek, J.
   Djedovic, G.
   Unger, L.
   Beck, H.
   Mattesich, M.
   Pierer, G.
   Koller, R.
   Rieger, U. M.
TI Outcomes for split-thickness skin transplantation in high-risk patients
   using octenidine
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE split-thickness skin graft; octenidine; tie-over dressing; cortisone
   therapy; diabetes mellitus; antiseptic wound management
ID RANDOMIZED CONTROLLED-TRIAL; DOUBLE-BLIND; DIHYDROCHLORIDE;
   COLONIZATION; DISINFECTION; WOUNDS
AB Skin transplantation is a commonly used surgical technique; however, the complication rate, including postoperative infection and delayed wound healing due to inefficient perfusion, is significantly higher in patients suffering from comorbidities. Hence, a subsequent repeat procedure is often necessary. In this report, two case studies are presented in which an octenidine-based antiseptic is used with a tie-over dressing (TOD) instead of povidone iodine (PVP-iodine), following a split-thickness skin graft. The two patients selected were deemed to be at high risk of impaired wound healing due to comorbidities. The first patient, a confirmed smoker with diabetes, presented with a nodular melanoma that was resected and covered with a split-thickness skin graft. After 5 days of negative pressure wound therapy as a TOD, in combination with PVP-iodine, the graft became necrotic. A second split-thickness skin graft was performed and an antiseptic regimen with octenidine in combination with the same TOD resulted in a completely healed transplant.
   The second patient, also a confirmed smoker with diabetes and receiving oral corticosteroid treatment, was diagnosed with a skin necrosis on her leg. Following the split-thickness skin graft, octenidine and TOD were applied. The patient's skin graft completely healed without any adverse events.
   These two case studies indicate that the combination of octenidine and TOD following split-thickness skin transplantation is safe, well-tolerated and appears to have positive benefits in the reconstruction of defects in patients with impaired wound healing.
C1 [Matiasek, J.; Unger, L.; Beck, H.; Koller, R.] Wilhelminenspital Stadt Wien, Dept Plast Aesthet & Reconstruct Surg, Vienna, Austria.
   [Matiasek, J.; Djedovic, G.; Mattesich, M.; Pierer, G.; Rieger, U. M.] Med Univ Innsbruck, Dept Plast Reconstruct & Aesthet Surg, A-6020 Innsbruck, Austria.
   [Djedovic, G.; Rieger, U. M.] St Markus Hosp, Dept Plast & Aesthet Surg, Reconstruct & Hand Surg, Frankfurt, Germany.
C3 Wilhelminenspital; Medical University of Innsbruck
RP Matiasek, J (通讯作者)，Wilhelminenspital Stadt Wien, Dept Plast Aesthet & Reconstruct Surg, Vienna, Austria.
EM johannes.matiasek@me.com
RI Unger, Lukas Walter/I-8768-2019
OI Unger, Lukas Walter/0000-0002-8423-2268
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NR 20
TC 9
Z9 11
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2015
VL 24
IS 6
SU S
BP S8
EP S12
DI 10.12968/jowc.2015.24.Sup6.S8
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CJ8PN
UT WOS:000355765800003
PM 26075514
DA 2026-07-24
ER
PT J
AU Mazoch, M
   Montgomery, C
AF Mazoch, M.
   Montgomery, C.
TI Retained wound vacuum foam in non-healing wounds: a real possibility
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; wound vacuum sponge; retained vacuum
   sponge; foreign body; wound vac
ID ASSISTED CLOSURE
AB Negative pressure wound therpay (NPWT) has revolutionised the management of chronic wounds, particularly pressure ulcers (PU). Frequently, PUs are too large to close primarily, so NPWT is used to assist in management on an outpatient basis. If not closely monitored, NPWT closure foam can be accidentally left in patients. Here we describe two cases where NPWT closure foam was left in patients resulting in persistent infections. Additionally, some suggestions of how to help avoid these should be 'never' events are provided.
C1 [Mazoch, M.; Montgomery, C.] Univ Arkansas Med Sci, Dept Orthoped, Little Rock, AR 72205 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences
RP Mazoch, M (通讯作者)，Univ Arkansas Med Sci, Dept Orthoped, 4301 W Markham,Suite 531, Little Rock, AR 72205 USA.
EM MJMazoch@uams.edu
CR Beral D, 2009, BMJ-BRIT MED J, V338, DOI 10.1136/bmj.b2269
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NR 8
TC 12
Z9 13
U1 1
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2015
VL 24
IS 6
SU S
BP S18
EP S20
DI 10.12968/jowc.2015.24.Sup6.S18
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CJ8PN
UT WOS:000355765800005
PM 26075511
DA 2026-07-24
ER
PT J
AU Fox, CM
   Johnson, B
   Storey, K
   Das Gupta, R
   Kimble, R
AF Fox, Carly M.
   Johnson, Bethan
   Storey, Kristen
   Das Gupta, Romi
   Kimble, Roy
TI Negative pressure wound therapy in the treatment of ulcerated infantile
   haemangioma
SO PEDIATRIC SURGERY INTERNATIONAL
LA English
DT Article
DE Negative pressure wound therapy; Infantile haemangioma; Vascular
   malformations; Wound healing
ID SUBATMOSPHERIC PRESSURE; PREVENTION; PROPRANOLOL; MULTICENTER;
   MANAGEMENT; INFECTION
AB Infantile haemangioma is a common benign tumour of infancy. Ulceration is the most common complication and is often painful and difficult to treat. Propranolol therapy is widely used to induce involution in rapidly growing or ulcerated lesions, or those in anatomically awkward locations. The ideal dressing regimen for these lesions would provide effective analgesia, act as a wound dressing, and aid involution of the primary lesion. To date, no ideal regimen has been established. Negative pressure wound therapy (NPWT) has been used in adult and paediatric populations to help improve wound healing in a variety of settings. It may provide a useful alternative to traditional dressing regimens in ulcerated infantile haemangioma.
   Six consecutive patients with ulcerating infantile haemangioma presenting to the Royal Children's Hospital vascular anomalies clinic were included in the study. Each patient was treated with a combination of NPWT and propranolol. Outcomes including time to wound healing, perceived ease of dressing management, and analgesia were recorded.
   Complete wound healing was obtained in all cases. Patient outcomes in terms of analgesia, comfort, and ease of wound dressing were improved following application of NPWT.
   We propose that this regimen represents a novel therapy for management of ulcerated infantile haemangioma. Possible mechanisms for healing effect, and improved analgesia are discussed. Further investigation is required to determine if negative pressure wound therapy results in faster healing times compared to traditional dressing regimens.
C1 [Fox, Carly M.; Johnson, Bethan; Storey, Kristen; Das Gupta, Romi; Kimble, Roy] Lady Cilento Childrens Hosp, Dept Paediat & Child Hlth, Vasc Anomalies Grp, Royal Childrens Hosp, South Brisbane, Qld 4101, Australia.
   [Johnson, Bethan; Storey, Kristen; Das Gupta, Romi; Kimble, Roy] Univ Queensland, Lady Cilento Childrens Hosp, Dept Paediat Surg, South Brisbane, Qld 4101, Australia.
   [Fox, Carly M.] Lady Cilento Childrens Hosp, Dept Plast & Reconstruct Surg, South Brisbane, Qld 4101, Australia.
C3 Childrens Health Queensland Hospital & Health Service; Queensland
   Childrens Hospital; University of Queensland; Childrens Health
   Queensland Hospital & Health Service; Queensland Childrens Hospital;
   Childrens Health Queensland Hospital & Health Service; Queensland
   Childrens Hospital
RP Fox, CM (通讯作者)，Lady Cilento Childrens Hosp, Dept Paediat & Child Hlth, Vasc Anomalies Grp, Royal Childrens Hosp, South Brisbane, Qld 4101, Australia.
EM carlymfox@gmail.com
RI Kimble, Roy/B-4160-2011
OI Kimble, Roy/0000-0002-2449-7707
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Choi WW, 2011, PEDIATR SURG INT, V27, P907, DOI 10.1007/s00383-011-2868-6
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NR 25
TC 11
Z9 12
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-0358
EI 1437-9813
J9 PEDIATR SURG INT
JI Pediatr. Surg. Int.
PD JUL
PY 2015
VL 31
IS 7
BP 653
EP 658
DI 10.1007/s00383-015-3716-x
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA CK0ZI
UT WOS:000355934000008
PM 25966985
DA 2026-07-24
ER
PT J
AU Swift, SH
   Zimmerman, MB
   Hardy-Fairbanks, AJ
AF Swift, Sara H.
   Zimmerman, M. Bridget
   Hardy-Fairbanks, Abbey J.
TI Effect of Single-Use Negative Pressure Wound Therapy on Postcesarean
   Infections and Wound Complications for High-Risk Patients
SO JOURNAL OF REPRODUCTIVE MEDICINE
LA English
DT Article
DE cellulitis; cesarean section; endometritis; endomyometritis;
   negative-pressure dressings; negative-pressure wound therapy;
   postcesarean section; Prevena; seroma; topical negative-pressure
   therapy; vacuum-assisted closure; wound infection
ID CLOSED INCISION MANAGEMENT; VACUUM-ASSISTED CLOSURE; SURGICAL INCISIONS;
   PREVENTION; EXPERIENCE; SURGERY; SYSTEM
AB OBJECTIVE: To evaluate the effect of a single-use negative pressure wound therapy (NPWT) system on postoperative complications after cesarean delivery.
   STUDY DESIGN: A historical control cohort of women was collected as part of a quality improvement project over a 6-month period. All women with at least 1 risk factor for postoperative complications were included in this control cohort. An intervention cohort of 110 women with at least 1 risk factor for postoperative complications was eligible to have a single-use NPWT system placed at the time of cesarean delivery. Primary outcomes were wound/infectious morbidity, including any surgical site infection (deep or superficial) as defined by the Centers for Disease Control, or wound separation without infection.
   RESULTS: Despite significantly higher overall burden of risk factors for postoperative complications, the intervention group showed a significantly lower rate (21.0% vs. 6.4%, p =0.0007) of overall wound/infectious morbidity. The rate of isolated wound separation between the 2 groups was not statistically significant (3.8% vs. 2.7%, p = 0.754) and was likely due to the low rate of wound separations.
   CONCLUSION: Application of an NPWT system to a primarily closed cesarean incision at time of surgery significantly decreased both deep and superficial infectious morbidity in our intervention group, which had more risk factors for wound complications and postoperative infection.
C1 Belin Hlth Care Syst, Green Bay, WI USA.
   Univ Iowa Hosp & Clin, Dept Biostat, Iowa City, IA 52242 USA.
   [Hardy-Fairbanks, Abbey J.] Univ Iowa Hosp & Clin, Dept Obstet & Gynecol, Iowa City, IA 52242 USA.
C3 University of Iowa; University of Iowa
RP Hardy-Fairbanks, AJ (通讯作者)，Univ Iowa Hosp & Clin, Dept Obstet & Gynecol, 200 Hawkins Dr, Iowa City, IA 52242 USA.
EM abbey-hardy-fairbanks@uiowa.edu
OI Hardy-Fairbanks, Abbey/0000-0003-4041-3937
CR [Anonymous], 2010, 390153WEB KIN CONC I
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   Wong Edward S., 1999, P189
NR 24
TC 30
Z9 33
U1 0
U2 11
PU SCI PRINTERS & PUBL INC
PI ST LOUIS
PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA
SN 0024-7758
EI 1943-3565
J9 J REPROD MED
JI J. Reprod. Med.
PD MAY-JUN
PY 2015
VL 60
IS 5-6
BP 211
EP 218
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CK3FL
UT WOS:000356101900006
PM 26126306
DA 2026-07-24
ER
PT J
AU Sporns, PB
   Zimmer, S
   Hanning, U
   Zoubi, T
   Wölfer, J
   Herbort, M
   Schwindt, W
   Niederstadt, T
AF Sporns, Peter Bernhard
   Zimmer, Sebastian
   Hanning, Uta
   Zoubi, Tarek
   Woelfer, Johannes
   Herbort, Mirco
   Schwindt, Wolfram
   Niederstadt, Thomas
TI Acute tonsillar cerebellar herniation in a patient with traumatic dural
   tear and VAC therapy after complex trauma
SO SPINE JOURNAL
LA English
DT Article
DE Trauma; VAC; Intracranial hypotension; Tonsillar herniation; Dural tear;
   Cerebrospinal fluid
AB BACKGROUND CONTEXT: Cases of cerebral hypotension and tonsillar herniation after accidental lumbar cerebrospinal fluid (CSF) drainage or chest tube drainage with intrathoracic CSF leaks have been reported. To the authors' knowledge, this case presents the first report of severe intracranial hypotension because of suction of CSF by a Vacuum-Assisted Closure (VAC) device.
   PURPOSE: The purpose of this study was to report a life-threatening intracranial hypotension in a polytraumatized patient after VAC therapy.
   STUDY DESIGN: This study is a case report.
   METHODS: A 23-year-old woman suffered of a Grade 3 open pelvic fracture after a motor vehicle accident. After a VAC therapy, the patient became nonresponsive. A cranial computer tomography (CCT) showed signs of intracranial hypotension with narrowing of the basal cisterns and sagging of the cerebellar tonsils. The VAC was removed. Further neuroradiological diagnostic showed a tear in the dural sac at the L5-S1 level. The patient consequently underwent neurosurgery. After a dural patch, she was oriented postoperatively and the CCT improved to a normal state.
   RESULTS: Fifteen days after admission, the patient was discharged without neurologic sequelae.
   CONCLUSIONS: Severely injured patients undergoing VAC therapy with secondary neurologic deterioration not because of head injury should be appropriately diagnosed to rule out dural laceration and cranial hypotension. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Sporns, Peter Bernhard; Zimmer, Sebastian; Hanning, Uta; Zoubi, Tarek; Schwindt, Wolfram; Niederstadt, Thomas] Univ Hosp, Dept Clin Radiol, D-48149 Munster, Germany.
   [Woelfer, Johannes] Univ Hosp, Dept Neurosurg, D-48149 Munster, Germany.
   [Herbort, Mirco] Univ Hosp, Dept Trauma Surg, D-48149 Munster, Germany.
C3 University of Munster; University of Munster; University of Munster
RP Sporns, PB (通讯作者)，Univ Hosp, Dept Clin Radiol, Albert Schweitzer Campus 1,Gebaude A1, D-48149 Munster, Germany.
EM peter.sporns@ukmuenster.de
RI Hanning, Uta/ACB-3126-2022
OI Hanning, Uta/0000-0002-7543-8555; Sporns, Peter
   Bernhard/0000-0002-3028-0539
CR Baugnon KL, 2014, NEUROIMAG CLIN N AM, V24, P439, DOI 10.1016/j.nic.2014.03.001
   Fehnel CR, 2014, BMJ CASE REP, V2014
   Kalani MYS, 2013, WORLD NEUROSURG, V79, DOI 10.1016/j.wneu.2011.04.028
   Lee SE, 2014, EUR SPINE J, V23, P1772, DOI 10.1007/s00586-014-3332-9
   Loya JJ, 2012, J NEUROSURG, V117, P615, DOI 10.3171/2012.4.JNS112030
   Luszczyk MJ, 2014, SPINE J, V14, P49, DOI 10.1016/j.spinee.2013.03.049
   Mokri B, 2000, Neurosurg Focus, V9, pe6
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   Sugrue PA, 2009, J NEUROSURG, V110, P800, DOI 10.3171/2008.5.17568
NR 12
TC 9
Z9 9
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1529-9430
EI 1878-1632
J9 SPINE J
JI Spine Journal
PD JUL 1
PY 2015
VL 15
IS 7
BP E13
EP E16
DI 10.1016/j.spinee.2015.04.025
PG 4
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA CK6BY
UT WOS:000356314000003
PM 25912500
DA 2026-07-24
ER
PT J
AU Fulco, I
   Erba, P
   Valeri, RC
   Vournakis, J
   Schaefer, DJ
AF Fulco, Ilario
   Erba, Paolo
   Valeri, Robert C.
   Vournakis, John
   Schaefer, Dirk J.
TI Poly-N-acetyl glucosamine nanofibers for negative-pressure wound
   therapies
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FIBERS; FOAM
AB The wound healing promoting effect of negative wound pressure therapies (NPWT) takes place at the wound interface. The use of bioactive substances at this site represents a major research area for the development of future NPWT therapies. To assess wound healing kinetics in pressure ulcers treated by NPWT with or without the use of a thin interface membrane consisting of poly-N-acetyl glucosamine nanofibers (sNAG) a prospective randomized clinical trial was performed. The safety of the combination of NPWT and sNAG was also assessed in patients treated with antiplatelet drugs. In the performed study, the combination of NPWT and sNAG in 10 patients compared to NPWT alone in 10 patients promoted wound healing due to an improved contraction of the wound margins (p=0.05) without a change in wound epithelization. In 6 patients treated with antiplatelet drugs no increased wound bleeding was observed in patients treated by NPWT and sNAG. In conclusion, the application of thin membranes of sNAG nanofibers at the wound interface using NPWT was safe and augmented the action of NPWT leading to improved wound healing due to a stimulation of wound contraction.
C1 [Fulco, Ilario; Erba, Paolo; Schaefer, Dirk J.] Univ Basel Hosp, Div Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
   [Erba, Paolo] Univ Lausanne Hosp, Div Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
   [Valeri, Robert C.] Naval Blood Res Lab, Boston, MA USA.
   [Vournakis, John] Marine Polymer Technol Inc, Danvers, MA USA.
C3 University of Basel
RP Erba, P (通讯作者)，Univ Basel Hosp, Dept Plast Reconstruct & Aesthet Surg, CH-4031 Basel, Switzerland.
EM erbapaolo@hotmail.com
RI Fulco, Ilario/Y-3177-2019; Schaefer, Dirk/I-9806-2018
OI Fulco, Ilario/0000-0001-8672-439X; 
FU Marine Polymer Technologies Inc., Danvers, MA, USA
FX Source of Funding: This study was supported by a research contract from
   Marine Polymer Technologies Inc., Danvers, MA, USA to University
   Hospital Basel, Switzerland.
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NR 17
TC 6
Z9 13
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2015
VL 23
IS 2
BP 197
EP 202
DI 10.1111/wrr.12273
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CK7YE
UT WOS:000356452000168
PM 25703411
DA 2026-07-24
ER
PT J
AU Kempton, LB
   Larson, TB
   Montijo, HE
   Seymour, RB
   Getz, SB
   Bosse, MJ
AF Kempton, Laurence B.
   Larson, Timothy B.
   Montijo, Harvey E.
   Seymour, Rachel B.
   Getz, Stanely B.
   Bosse, Michael J.
TI Increased Cost of Negative Pressure Dressings Is Not Justified for
   Split-Thickness Skin Grafting of Low-Risk Wounds
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE split-thickness skin graft; negative pressure dressing; negative
   pressure therapy; trauma
ID VACUUM-ASSISTED CLOSURE; FOLLOW-UP; THERAPY; BOLSTER; DEVICE;
   MANAGEMENT; FIXATION; DEFECTS; TRAUMA; TRIAL
AB Objectives:(1) To determine whether negative pressure dressings (NPDs) are superior to conventional compressive dressings (CDs) for split-thickness skin grafts (STSGs) placed on healthy, low-risk wounds, (2) To determine the cost difference of NPDs versus that of CDs.Design:Retrospective.Setting:Level I Trauma Center.Patients/Participants:One hundred ninety-five traumatic wounds treated with STSG.Main Outcome Measurements:Patients were assigned outcomes based on postoperative documentation: completely healed, incompletely healed (small areas of graft necrosis), failed, or lost to follow-up. The costs associated with each dressing type were documented.Results:Thirty five of 195 STSGs were lost to follow-up, leaving n = 120 STSG-NPD, n = 40 STSG-CD. Of the remaining 120 STSGs treated with NPD, 91 completely healed, 23 incompletely healed, and 6 failed. Of the 40 STSGs treated with a CD, 37 completely healed, 1 incompletely healed, and 2 failed. Patients treated with CDs had a higher likelihood of healing relative to those treated with the NPD (P = 0.018). Analyzing the outcomes as failed versus not failed revealed no significant difference between the groups (P = 1.00). There were more smokers in the CD group (P = 0.022). In this series, the mean cost associated with NPD compared with that of CD was $2370 more per patient.Conclusions:There is a high rate of successful healing of STSGs for traumatic extremity wounds regardless of the dressing used. The increased cost of NPDs is not justified in wounds that are at a low risk of developing STSG failure.Level of Evidence:Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
C1 [Kempton, Laurence B.; Larson, Timothy B.; Montijo, Harvey E.; Seymour, Rachel B.; Bosse, Michael J.] Carolinas Med Ctr, Dept Orthopaed Surg, Charlotte, NC 28203 USA.
   [Getz, Stanely B.] Carolinas Med Ctr, Dept Gen Surg, Charlotte, NC 28203 USA.
C3 Carolinas Medical Center; Carolinas Medical Center
RP Bosse, MJ (通讯作者)，Carolinas HealthCare Syst, Dept Orthopaed Surg, 1320 Scott Ave, Charlotte, NC 28204 USA.
EM michael.bosse@carolinashealthcare.org
OI Seymour, Rachel/0000-0002-9203-8297
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NR 38
TC 15
Z9 17
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD JUL
PY 2015
VL 29
IS 7
BP 301
EP 306
DI 10.1097/BOT.0000000000000259
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA CK8LW
UT WOS:000356490600001
PM 25463425
DA 2026-07-24
ER
PT J
AU Kao, HK
   Hsu, HH
   Chuang, WY
   Chang, KP
   Chen, B
   Guo, L
AF Kao, H. -K.
   Hsu, H. -H.
   Chuang, W. -Y.
   Chang, K. -P.
   Chen, B.
   Guo, L.
TI Experimental study of fat grafting under negative pressure for wounds
   with exposed bone
SO BRITISH JOURNAL OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MESENCHYMAL STEM-CELLS; ANGIOGENESIS;
   PROLIFERATION; MECHANISMS; DEATH; ADIPOCYTES; ACTIVATION; THERAPY;
   MATRIX
AB BackgroundThe combination of fat grafting and negative pressure (VAC) therapy represents a synergistic interaction of all essential components for wound healing. The aim of this experimental study was to determine whether it could promote healing of wounds with exposed bone.
   MethodsFull-thickness wounds with denuded bone in Sprague-Dawley rats were treated with either polyurethane foam dressing, fat grafting alone, polyurethane foam dressing with VAC, or polyurethane foam dressing with VAC combined with a single, or two administrations of fat graft. Wound healing kinetics, tissue growth, cell proliferation (Ki-67) and angiogenesis (platelet endothelial cell adhesion molecule 1 and -smooth muscle actin) were investigated. Messenger RNA levels related to angiogenesis (vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF)), profibrosis (platelet-derived growth factor A and transforming growth factor ), adipocyte expression (fatty acid-binding protein (FABP) 4 and peroxisome proliferator activated receptor ), and extracellular matrix remodelling (collagen I) were measured in wound tissues.
   ResultsWounds treated by VAC combined with fat grafting were characterized by cell proliferation, neoangiogenesis and maturation of functional blood vessels; they showed accelerated granulation tissue growth over the denuded bone compared with VAC- or foam dressing-treated wounds. Fat grafting alone over denuded bone resulted in complete necrosis. Expression of angiogenesis markers (VEGF and b-FGF) and adipocyte expression factors (FABP-4) was upregulated in wounds treated with VAC combined with fat grafting.
   ConclusionFat grafting with VAC therapy may represent a simple but effective clinical solution for a number of complex tissue defects, and warrants testing in clinical models.
C1 [Kao, H. -K.] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Taoyuan, Taiwan.
   [Hsu, H. -H.] Chang Gung Mem Hosp, Kidney Res Ctr, Dept Nephrol, Taoyuan, Taiwan.
   [Chuang, W. -Y.] Chang Gung Mem Hosp, Dept Pathol, Taoyuan, Taiwan.
   [Chang, K. -P.] Chang Gung Mem Hosp, Dept Otolaryngol & Head Neck Surg, Taoyuan, Taiwan.
   [Chang, K. -P.] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
   [Chen, B.; Guo, L.] Lahey Hosp & Med Ctr, Dept Plast Surg, Burlington, MA 01805 USA.
   [Chen, B.] Kunming Med Univ, Burn Inst Yunnan Prov, Dept Reparat & Reconstruct Surg, Affiliated Hosp 2, Kunming, Peoples R China.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung University;
   Lahey Hospital & Medical Center; Kunming Medical University
RP Guo, L (通讯作者)，Lahey Hosp & Med Ctr, Dept Plast Surg, 41 Mall Rd,6W, Burlington, MA 01805 USA.
EM lifei.guo@lahey.org
RI /AAG-3449-2019; Chuang, Wen-Yu/I-8013-2019
OI Chen, Bin/0000-0002-7606-1382; Chuang, Wen-Yu/0000-0002-3729-073X; Guo,
   Lifei/0000-0003-2019-0086
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NR 23
TC 20
Z9 25
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD JUL
PY 2015
VL 102
IS 8
BP 998
EP 1005
DI 10.1002/bjs.9826
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CK8VD
UT WOS:000356516400018
PM 25974177
OA Bronze
DA 2026-07-24
ER
PT J
AU Sziklavari, Z
   Ried, M
   Hofmann, HS
AF Sziklavari, Z.
   Ried, M.
   Hofmann, H. -S.
TI Intrathoracic Vacuum-Assisted Closure in the Treatment of Pleural
   Empyema and Lung Abscess
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE vacuum-assisted closure; VAC; pleural empyema; lung abscess; Mini-VAC;
   Mini-VAC-Instill
ID OPEN-WINDOW THORACOSTOMY; PRESSURE WOUND THERAPY; POSTPNEUMONECTOMY
   EMPYEMA; MANAGEMENT
AB Background: Complex pleural empyema or lung abscesses are either characterised by long-standing treatment (including treatment failure) or by a bad general condition of the patient (multiple morbidity, sepsis). The operative rectification is often associated with increased morbidity and mortality rates in these cases. Traditionally, the therapeutic tendency for such patients was towards primary creation of a thoracic window including open wound treatment, but this was always also associated with a long sickness and restrictions in the quality of life. The intrathoracic vacuum treatment (VAC) offers here entirely new options in the treatment of complicated pleural empyema and lung abscesses.
   Method: We present an illustration of our own clinical experience associated with a selective literature research via Medline (keywords: VAC, vacuum-assisted closure, thoracic empyema).
   Results: After the initial successes of the extra-thoracic application of the VAC treatment, the procedure was also analysed for its intrathoracic/pleural use to treat pleural empyema and lung abscesses with and without bronchus stump insufficiency. Initially, the use of the intrathoracic VAC treatment was carried out via a thoracic window (with rib resection), later we developed a minimally invasive procedure (Mini-VAC) while relieving the osseous thorax. An additional intrapleural rinsing with antiseptics (Mini-VAC-Instill) is very practical in cases of proven germ populations. The benefits of the Mini-Vac/Mini-VAC-Instill are: immediate secretion suction with quick local cleaning, rapid germ eradication with a small risk of a fresh population, improvement of the expansion behaviour of the lung as well as short treatment times with quick reclosure of the thorax. In addition to many retrospective examinations, there has so far only been one cohort study in which the classic thoracic window was compared with the VAC treatment. The duration of the stomatic situation as well as the long-term survival in the VAC group were better here than those in the non-VAC group.
   Conclusion: The intrathoracic VAC treatment (Mini-Vac/Mini-VAC-Instill) is an innovative procedure that promotes wound cleaning and wound healing in complicated pleural empyema and lung abscesses. Due to the benefits of this procedure, including the improvement of the patient ' s comfort and the quality of life, the procedure has seen a rapid and broad clinical acceptance.
C1 [Sziklavari, Z.; Hofmann, H. -S.] Krankenhaus Barmherzige Bruder, Klin Thoraxchirurg, D-93049 Regensburg, Germany.
   [Ried, M.; Hofmann, H. -S.] Univ Klinikum Regensburg, Klin Thoraxchirurg, Regensburg, Germany.
C3 University of Regensburg
RP Sziklavari, Z (通讯作者)，Krankenhaus Barmherzige Bruder, Klin Thoraxchirurg, Prufeningerstr 86, D-93049 Regensburg, Germany.
EM zsolt.sziklavari@barmherzige-regensburg.de
RI Ried, Michael/AAC-4518-2022; Sziklavari, Zsolt/AGI-2440-2022
OI Ried, Michael/0000-0002-2365-4803; 
CR Al-Mufarrej F, 2010, SURG TODAY, V40, P711, DOI 10.1007/s00595-008-4096-9
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NR 38
TC 8
Z9 9
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD JUN
PY 2015
VL 140
IS 3
BP 321
EP 327
DI 10.1055/s-0034-1383273
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CL5YC
UT WOS:000357040200024
PM 25906022
DA 2026-07-24
ER
PT J
AU Bozkurt, B
   Tokac, M
   Dumlu, EG
   Yalcin, A
   Kilic, M
AF Bozkurt, B.
   Tokac, M.
   Dumlu, E. G.
   Yalcin, A.
   Kilic, M.
TI Our First Experience With Negative Pressure Incision Management System
   Implemented on the Clean Surgical Incision in the Renal Transplantation
   Recipient: A Case Report
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article
ID WOUND-HEALING COMPLICATIONS; KIDNEY-TRANSPLANTATION; THERAPY; SERIES
AB Multiple comorbidities and environmental factors increase the complications of incisional wounds in patients. It was demonstrated in previous prospective and randomized studies that negative pressure wound therapy (NPWT) reduced wound infection and other complications in clean, closed surgical incisions. In this case report, the Prevena incision management system was implemented on the clean, closed surgical incision of a 52-year-old female patient, who was given a renal transplantation from cadaver postoperatively in the operating theater. It was removed from the patient on the fifth day after the operation. Following the removal of Prevena, the wound and surrounding skin of the patient were observed. Wound healing was complete, and no skin lesion or tool-related complication was found around the wound due to NPWT. The Prevena NPWT system can be conveniently and safely implemented on the operational incision in renal transplant recipients in order to prevent surgical wound complications.
C1 [Bozkurt, B.; Tokac, M.; Dumlu, E. G.] Ataturk Training & Res Hosp, Organ Transplantat Ctr, Ankara, Turkey.
   [Yalcin, A.; Kilic, M.] Yildirim Beyazit Univ, Dept Gen Surg, Ankara, Turkey.
C3 Ankara Etlik Ihtisas Egitim ve Arastirma Hastanesi; Ankara Yildirim
   Beyazit University
RP Bozkurt, B (通讯作者)，Ataturk Training & Res Hosp, Organ Transplantat Ctr, Eskisehir Yolu 8 Km 2,Bilkent, Ankara, Turkey.
EM birkan.bozkurt@gmail.com
RI bozkurt, birkan/AAN-9219-2020; yalçın, abdussamed/JQW-2480-2023; TOKAÇ,
   MEHMET/AAA-9577-2021
OI TOKAÇ, MEHMET/0000-0002-7278-0937
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NR 16
TC 8
Z9 9
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD JUN
PY 2015
VL 47
IS 5
BP 1515
EP 1517
DI 10.1016/j.transproceed.2015.04.057
PG 3
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Surgery; Transplantation
GA CL6GY
UT WOS:000357066800067
PM 26093755
DA 2026-07-24
ER
PT J
AU Rasilainen, SK
   Juhani, MP
   Kalevi, LA
AF Rasilainen, Suvi Kaarina
   Juhani, Mentula Panu
   Kalevi, Leppaniemi Ari
TI Microbial colonization of open abdomen in critically ill surgical
   patients
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Open abdomen; Laparostomy; Temporary abdominal closure; Microbial
   colonization
ID ASSISTED WOUND CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; MEDIATED FASCIAL
   TRACTION; INTRAABDOMINAL HYPERTENSION; DAMAGE CONTROL; ENTEROATMOSPHERIC
   FISTULAS; PERITONEAL-CAVITY; ENTERIC FISTULA; OPEN MANAGEMENT; VACUUM
AB Introduction: This study was designed to describe the time-course and microbiology of colonization of open abdomen in critically ill surgical patients and to study its association with morbidity, mortality and specific complications of open abdomen. A retrospective cohort analysis was done.
   Methods: One hundred eleven consecutive patients undergoing vacuum-assisted closure with mesh as temporary abdominal closure method for open abdomen were analyzed. Microbiological samples from the open abdomen were collected. Statistical analyses were performed using Fisher's exact test for categorical variables. Mann-Whitney U test was used when comparing number of temporary abdominal closure changes between colonized and sterile patients. Kaplan-Meier analysis was done to calculate cumulative estimates for colonization. Cox regression analyses were performed to analyze risk factors for colonization.
   Results: Microbiological samples were obtained from 97 patients. Of these 76 (78 %) were positive. Sixty-one (80 %) patients were colonized with multiple micro-organisms and 27 (36 %) were cultured positive for candida species. The duration of open abdomen treatment adversely affected the colonization rate. Thirty-three (34 %) patients were colonized at the time of laparostomy. After one week of open abdomen treatment 69, and after two weeks 76 patients were colonized with cumulative colonization estimates of 74 % and 89 %, respectively. Primary fascial closure rate was 80 % (61/76) and 86 % (18/21) for the colonized and sterile patients, respectively. The rate of wound complications did not significantly differ between these groups.
   Conclusions: Microbial colonization of open abdomen is associated with the duration of open abdomen treatment. Wound complications are common after open abdomen, but colonization does not seem to have significant effect on these. The high colonization rate described herein should be taken into account when primarily sterile conditions like acute pancreatitis and aortic aneurysmal rupture are treated with open abdomen.
C1 [Rasilainen, Suvi Kaarina] Jorvi Hosp, Dept Abdominal Surg, Espoo 150, Finland.
   [Juhani, Mentula Panu; Kalevi, Leppaniemi Ari] Univ Helsinki, Cent Hosp, Dept Abdominal Surg, Helsinki, Finland.
C3 University of Helsinki; Helsinki University Central Hospital
RP Rasilainen, SK (通讯作者)，Jorvi Hosp, Dept Abdominal Surg, Espoo 150, Finland.
EM rasilainensuvi@gmail.com
RI Mentula, Panu/H-9025-2019
OI Mentula, Panu/0000-0002-6516-3797
FU Helsinki University Hospital
FX This study was financially supported only by a Helsinki University
   Hospital research grant for emergency abdominal-surgery.
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NR 38
TC 15
Z9 19
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JUN 25
PY 2015
VL 10
AR 25
DI 10.1186/s13017-015-0018-5
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA CL7LP
UT WOS:000357153900001
PM 26136816
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Cao, L
   Peng, MM
   Sun, JJ
   Yu, XC
   Shi, B
AF Cao, L.
   Peng, M. M.
   Sun, J. J.
   Yu, X. C.
   Shi, B.
TI Application of vacuum-assisted closure in seawater-immersed wound
   treatment under different negative pressures
SO GENETICS AND MOLECULAR RESEARCH
LA English
DT Article
DE Vacuum-assisted closure; Wound therapy; Seawater immersion; Negative
   pressure
ID SKIN-GRAFTS; THERAPY; DEVICE; EXPRESSION; EXPERIENCE; REPAIR
AB The therapeutic effect of vacuum-assisted closure (VAC) has been confirmed in many types of complex wounds, but there are few relevant reports regarding seawater-immersed wounds. The aim of this study was to determine the effect of VAC on seawater-immersed wound healing under different negative pressures and explore the optimal negative pressure value. Four purebred miniature pigs were used as the experimental animal models. Four acute, symmetrical wounds were made on each side of the spine and designated as the experimental group (wounds with 2 h of seawater immersion) and the control group (wounds without seawater immersion). Wounds were divided into a conventional dressing group and 3 further groups with different VAC therapies (negative pressure at either 120, 180, or 240 mmHg). The extent of wound healing, and speed of granulation growth and re-epithelialization were measured. Bacterial flora distribution in the wounds was observed, and fibronectin levels in the exudate of the wounds were tested. Results showed that seawater immersion aggravated wound injury and that VAC therapy with 180 mmHg negative pressure induced the fastest epidermis migration, obvious edema elimination, significant capillary proliferation, and the highest level of fibronectin, and that in wounds, the proportion of Gram-negative bacteria tended to decrease and that of Gram-positive bacteria tended to increase. Our results show that VAC promotes seawater-immersed wound healing and that 180 mmHg negative pressure may be optimal for wound healing.
RP Shi, B (通讯作者)，Chinese Peoples Liberat Army Gen Staff Hosp, Dept Plast Surg, Beijing, Peoples R China.
EM shibingbeijing@126.com
FU Natural Science Research Foundation of China
FX Research supported by grants from the Natural Science Research
   Foundation of China.
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NR 26
TC 4
Z9 5
U1 0
U2 15
PU FUNPEC-EDITORA
PI RIBEIRAO PRETO
PA RUA FLORIANO PEIXOTO 2444, ALTO DA BOA VISTA, RIBEIRAO PRETO, SP 00000,
   BRAZIL
SN 1676-5680
J9 GENET MOL RES
JI Genet. Mol. Res.
PY 2015
VL 14
IS 2
BP 6146
EP 6155
DI 10.4238/2015.June.8.12
PG 10
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CL7YU
UT WOS:000357189800044
PM 26125815
OA Bronze
DA 2026-07-24
ER
PT J
AU Marston, WA
   Armstrong, DG
   Reyzelman, AM
   Kirsner, RS
AF Marston, William A.
   Armstrong, David G.
   Reyzelman, Alexander M.
   Kirsner, Robert S.
TI A Multicenter Randomized Controlled Trial Comparing Treatment of Venous
   Leg Ulcers Using Mechanically Versus Electrically Powered Negative
   Pressure Wound Therapy
SO ADVANCES IN WOUND CARE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; QUALITY-OF-LIFE; SURROGATE END-POINTS; CARE;
   INSUFFICIENCY; MANAGEMENT; ULCERATION; SYSTEM; IMPACT
AB Objective: This study compares two different negative pressure wound therapy (NPWT) modalities in the treatment of venous leg ulcers (VLUs), the ultraportable mechanically powered (MP) Smart Negative Pressure (SNaP (R)) Wound Care System to the electrically powered (EP) Vacuum-Assisted Closure (V.A.C.(R)) System.
   Approach: Patients with VLUs from 13 centers participated in this prospective randomized controlled trial. Each subject was randomly assigned to treatment with either MP NPWT or EP NPWT and evaluated for 16 weeks or complete wound closure.
   Results: Forty patients (n = 19 MP NPWT and n = 21 EP NPWT) completed the study. Primary endpoint analysis of wound size reduction found wounds in the MP NPWT group had significantly greater wound size reduction than those in the EP NPWT group at 4, 8, 12, and 16 weeks (p-value = 0.0039, 0.0086, 0.0002, and 0.0005, respectively). Kaplan-Meier analyses showed greater acceleration in complete wound closure in the MP NPWT group. At 30 days, 50% wound closure was achieved in 52.6% (10/19) of patients treated with MP NPWT and 23.8% (5/21) of patients treated with EP NPWT. At 90 days, complete wound closure was achieved in 57.9% (11/19) of patients treated with MP NPWT and 38.15% (8/21) of patients treated with EP NPWT.
   Innovation: These data support the use of MP-NPWT for the treatment of VLUs.
   Conclusions: In this group of venous ulcers, wounds treated with MP NPWT demonstrated greater improvement and a higher likelihood of complete wound closure than those treated with EP NPWT.
C1 [Marston, William A.] Univ N Carolina, Dept Surg, Div Vasc Surg, Sch Med, Chapel Hill, NC 27599 USA.
   [Armstrong, David G.] Univ Arizona, Coll Med, SALSA, Tucson, AZ USA.
   [Reyzelman, Alexander M.] Samuel Merritt Univ, Calif Sch Podiatr Med, Dept Med, Oakland, CA USA.
   [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; University of Arizona;
   Samuel Merritt University; University of Miami
RP Marston, WA (通讯作者)，Univ N Carolina, Dept Surg, Div Vasc Surg, Sch Med, Chapel Hill, NC 27599 USA.
EM sky@med.unc.edu
CR Apostoli Alberto, 2008, Prof Inferm, V61, P158
   Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
   Armstrong DG, 2011, WOUND REPAIR REGEN, V19, P173, DOI 10.1111/j.1524-475X.2010.00658.x
   Borgquist O, 2011, OSTOMY WOUND MANAG, V57, P44
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Dowsett C, 2012, INT WOUND J, V9, P544, DOI 10.1111/j.1742-481X.2011.00913.x
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NR 41
TC 14
Z9 18
U1 0
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD FEB
PY 2015
VL 4
IS 2
BP 75
EP 82
DI 10.1089/wound.2014.0575
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CL8XP
UT WOS:000357257800001
PM 25713749
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Das Ghatak, P
   Schlanger, R
   Ganesh, K
   Lambert, L
   Gordillo, GM
   Martinsek, P
   Roy, S
AF Das Ghatak, Piya
   Schlanger, Richard
   Ganesh, Kasturi
   Lambert, Lynn
   Gordillo, Gayle M.
   Martinsek, Patsy
   Roy, Sashwati
TI A Wireless Electroceutical Dressing Lowers Cost of Negative Pressure
   Wound Therapy
SO ADVANCES IN WOUND CARE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TRAUMA; TISSUE
AB Objective: To test whether the use of a wireless electroceutical dressing (WED) (Procellera (R)) in conjunction with a 5-day negative pressure wound therapy (NPWT) may reduce the number of dressing changes required per week with this therapy.
   Approach: At the Ohio State University Comprehensive Wound Center, chronic wound patients (n = 30) undergoing NPWT were randomized into two arms following consent as approved by the institutional review board. The control arm received standard of care NPWT, where the dressing change was performed thrice a week. The test arm received the same care except that the WED was added as an interface layer and dressing change was limited to twice a week.
   Results: A reduced cost of care was achieved using the WED in conjunction with NPWT. Despite fewer dressing changes in wounds dressed with the WED, closure outcomes were comparable with no overt signs of any wound complication, including infection. The cost of NPWT care during the week was significantly lower (from $2918 to $2346) in the WED-treated group compared with patients in the control arm.
   Innovation: This work introduces a novel technology platform involving a WED, which may be used in conjunction with NPWT. If used as such, NPWT is effective in decreasing the frequency of dressing change and lowering the cost of care.
   Conclusion: This work points toward the benefit of using the WED combined with NPWT. A larger clinical trial investigating the cost-effectiveness of WED in wound care is warranted.
C1 [Roy, Sashwati] Ohio State Univ, Dept Surg, Comprehens Wound Ctr, Wexner Med Ctr, Columbus, OH 43210 USA.
   Ohio State Univ, Dept Plast Surg, Comprehens Wound Ctr, Wexner Med Ctr, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Roy, S (通讯作者)，Ohio State Univ, Dept Surg, Comprehens Wound Ctr, Wexner Med Ctr, 511 DHLRI, Columbus, OH 43210 USA.
EM sashwati.roy@osumc.edu
RI ; Gordillo, Gayle/LPP-8918-2024
OI Roy, Sashwati/0000-0002-9995-4917; Gordillo, Gayle/0000-0001-8369-6637
CR Abarca-Buis RF, 2014, ADV SKIN WOUND CARE, V27, P156, DOI 10.1097/01.ASW.0000444849.71374.bc
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NR 27
TC 22
Z9 30
U1 1
U2 24
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAY
PY 2015
VL 4
IS 5
BP 302
EP 311
DI 10.1089/wound.2014.0615
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CL8YI
UT WOS:000357260300004
PM 26005596
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Bradbury, S
   Walkley, N
   Ivins, N
   Harding, K
AF Bradbury, Sarah
   Walkley, Neal
   Ivins, Nicola
   Harding, Keith
TI Clinical Evaluation of a Novel Topical Negative Pressure Device in
   Promoting Healing in Chronic Wounds
SO ADVANCES IN WOUND CARE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; THERAPY; MULTICENTER;
   MANAGEMENT; SYSTEM; ULCERS; LEG; ULCERATION; PROTEASES
AB Aim: This observational study evaluated the use of a novel, ultraportable, mechanically powered topical negative pressure device in promoting healing in chronic wounds, including venous and mixed etiology leg ulcers and neuropathic foot ulcers.
   Materials and Methods: Evaluable patients (n = 37) received treatment with the SNaP (R) Wound Care System for up to 6 weeks. The primary objective was percentage change in wound size, with secondary objectives of clinical assessment of wound parameters, ease of use, and impact on quality of life.
   Results: A 42.64% mean percentage decrease in wound area was observed, with an overall decrease for each wound etiology subgroup. Increased granulation tissue, decreased exudate levels, and decreased wound pain were reported. Quality-of-life scores increased overall, and the device was easy to use, comfortable, portable, and inconspicuous.
   Conclusion: The SNaP Wound Care System has the potential to promote healing in chronic wounds of different etiologies.
C1 [Bradbury, Sarah; Walkley, Neal; Ivins, Nicola; Harding, Keith] Cardiff Univ, Sch Med, Wound Healing Res Unit, Rm 18 UGF,Hlth Pk, Cardiff CF14 4XN, S Glam, Wales.
C3 Cardiff University
RP Walkley, N (通讯作者)，Cardiff Univ, Sch Med, Wound Healing Res Unit, Rm 18 UGF,Hlth Pk, Cardiff CF14 4XN, S Glam, Wales.
EM walkleyna@cardiff.ac.uk
RI Bradbury, Sarah/KBR-2907-2024; Harding, Keith/J-5605-2013
OI Harding, Keith/0000-0003-0048-3279
FU Spiracur Inc.
FX This observational study was supported by funding from Spiracur Inc.
CR Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
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   World Union of Wound Healing Societies (WUWHS), 2008, WORLD UN WOULD HEAL
NR 40
TC 9
Z9 11
U1 0
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUN
PY 2015
VL 4
IS 6
BP 346
EP 357
DI 10.1089/wound.2014.0596
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CL8YL
UT WOS:000357260600004
PM 26029485
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Matsumoto, T
   Parekh, SG
AF Matsumoto, Takumi
   Parekh, Selene G.
TI Use of Negative Pressure Wound Therapy on Closed Surgical Incision After
   Total Ankle Arthroplasty
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE dressing; incisional negative pressure wound therapy; surgical
   complications; total ankle arthroplasty; wound healing problem
ID VACUUM-ASSISTED CLOSURE; FOLLOW-UP; HIP-ARTHROPLASTY; RISK-FACTORS;
   COMPLICATIONS; REPLACEMENT; MANAGEMENT; DRAINAGE; PROSTHESES; FRACTURES
AB Background: Wound healing problems of the anterior ankle incision are among the most common complications after total ankle arthroplasty, possibly resulting in exposure of the prostheses and infection. The aim of this study was to investigate the role of negative pressure wound therapy (NPWT) in decreasing the rate of wound healing problems after total ankle arthroplasty.
   Methods: This is a retrospective cohort study including consecutive patients who underwent total ankle arthroplasty by a single surgeon at a single institution between 2009 and 2013. The incisional negative pressure dressing was applied to all patients who underwent total ankle arthroplasty between 2012 and 2013 with a continuous application of -80 mm Hg negative pressure for 6 days postoperatively. The control group consisted of patients who underwent total ankle arthroplasty between 2009 and 2012 with a conventional nonadherent gauze dressing. Seventy-four patients were involved in this study: 37 in the control group and 37 in the incisional NPWT group.
   Results: All patients tolerated the incisional NPWT to completion without any dressing failures or skin problems. Both groups showed similar distributions in demographics and perioperative risk factors for wound healing. There were 9 (24%) wound healing problems in the control group and 1 (3%) in the incisional NPWT group. Incisional NPWT was found to reduce wound healing problems with an odds ratio of 0.10 (95% CI, 0.01-0.50; P = .004).
   Conclusions: Our study demonstrated that there was a decreased incidence of wound healing problems following total ankle arthroplasty with incisional NPWT dressings. This is the first study evaluating the efficacy of incisional NPWT as an adjunct treatment for wound healing after total ankle arthroplasty.
   Level of Evidence: Level III, retrospective comparative study.
C1 [Matsumoto, Takumi; Parekh, Selene G.] Duke Univ, Dept Orthopaed Surg, Med Ctr, Durham, NC USA.
   [Parekh, Selene G.] Duke Fuqua Sch Business, Durham, NC USA.
C3 Duke University; Duke University
RP Parekh, SG (通讯作者)，Duke Univ Hosp, North Carolina Orthopaed Clin, Dept Orthopaed, 3609 Southwest Durham Dr, Durham, NC 27709 USA.
EM selene.parekh@gmail.com
OI Parekh, Selene/0000-0002-1308-9038
CR Anderson T, 2003, J BONE JOINT SURG AM, V85A, P1321, DOI 10.2106/00004623-200307000-00019
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   Webster J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub2
   Whalen JL, 2010, FOOT ANKLE INT, V31, P301, DOI 10.3113/FAI.2010.0301
   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
   Zaidi R, 2013, BONE JOINT J, V95B, P1500, DOI 10.1302/0301-620X.95B11.31633
NR 40
TC 45
Z9 50
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD JUL
PY 2015
VL 36
IS 7
BP 787
EP 794
DI 10.1177/1071100715574934
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CL9KA
UT WOS:000357295900007
PM 25736324
DA 2026-07-24
ER
PT J
AU Sano, H
   Ichioka, S
AF Sano, Hitomi
   Ichioka, Shigeru
TI Involvement of nitric oxide in the wound bed microcirculatory change
   during negative pressure wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Blood flow; Intravital microscope; L-NAME; Mechanical stress
ID VACUUM-ASSISTED CLOSURE; SYNTHASE; PHOSPHORYLATION; ARTERY
AB This study investigated the role of nitric oxide (NO) in the mechanism of blood flow increase in the wound bed during negative pressure wound therapy (NPWT). We developed an improved experimental model that allowed visualisation of the wound bed microcirculation under NPWT. Wounds were created on the mouse ear, taking care to preserve the subdermal vascular plexus, because the wound bed microcirculation was visualised using an intravital microscope system. We investigated whether application of a NO synthase inhibitor (N-G-nitro-l-arginine methyl ester: L-NAME) might diminish the effect of the NPWT in increasing the wound blood flow. The experimental animals were divided into a negative pressure group (negative pressure of -125 mmHg applied to the wound for 5 minutes; n = 8), and a negative pressure plus L-NAME group (administration of L-NAME prior to application of the negative pressure; n = 8). In the negative pressure group, significant increase of blood flow was observed at 1 minute after the negative pressure application, which was sustained until 5 minutes. On the contrary, in the negative pressure plus L-NAME group, no significant changes were observed throughout the period of observation. These findings suggest that NO synthesis is involved in the wound bed microcirculatory change induced by NPWT.
C1 [Sano, Hitomi] Univ Tokyo, Grad Sch Med, Dept Surg Sci, Tokyo, Japan.
   [Ichioka, Shigeru] Saitama Med Univ, Dept Plast & Reconstruct Surg, Moroyama, Saitama 3500495, Japan.
C3 University of Tokyo; Saitama Medical University
RP Ichioka, S (通讯作者)，Saitama Med Univ, Dept Plast & Reconstruct Surg, 38 Morohongo, Moroyama, Saitama 3500495, Japan.
EM ichioka2006@yahoo.co.jp
FU Grants-in-Aid for Scientific Research [23592652] Funding Source: KAKEN
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NR 21
TC 6
Z9 8
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2015
VL 12
IS 4
BP 397
EP 401
DI 10.1111/iwj.12121
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CM2OI
UT WOS:000357520400004
PM 23834415
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Langer, V
   Bhandari, PS
   Rajagopalan, S
   Mukherjee, MK
AF Langer, Vijay
   Bhandari, Prem S.
   Rajagopalan, Satyamoorthy
   Mukherjee, Mrinal K.
TI Negative pressure wound therapy as an adjunct in healing of chronic
   wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chronic wounds; Negative pressure wound therapy; Vacuum sealing
   technique; Wound bed preparation; Wounds and injuries
ID VACUUM-ASSISTED CLOSURE; GLYCATION END-PRODUCTS; EXPERIENCE; DEVICE;
   TRIAL
AB Negative pressure wound therapy (NPWT) has emerged as a cutting-edge technology and provides an alternative solution to the problem of wounds. This study was undertaken to assess the efficacy of this technique in the treatment of chronic wounds. A prospective clinical study was used to evaluate our experience in use of NPWT in the healing of pressure ulcers and chronic wounds over 2 years. The primary end point of the study group was the time taken for appearance of healthy granulation tissue and full reepithelialisation without drainage. All patients with sepsis were excluded from the study. The statistical analysis of the data was carried out. Of the 60 patients studied, 41 had associated comorbidities including diabetes mellitus. The commonest site of occurrence was the lower limb. Coverage in the form of a flap was required at presentation in 6333% of patients. However, after initiation of NPWT, none of them required the procedure and they healed spontaneously either by secondary intention or by skin grafting. The time taken for appearance of healthy granulation tissue was 1436 +/- 424 days. Complete healing of wounds occurred by 331 +/- 1022 days. There was a statistically significant difference in the volume of the wounds before and after the intervention (P = 0000). Complications resulting from NPWT were minimal. This technique is an excellent adjunct to surgical debridement.
C1 [Langer, Vijay; Bhandari, Prem S.; Mukherjee, Mrinal K.] Army Hosp Res & Referral, Dept Plast & Reconstruct Surg, New Delhi 110010, India.
   [Rajagopalan, Satyamoorthy] Armed Forces Med Coll, Dept Surg, Pune, Maharashtra, India.
C3 Armed Forces Medical College
RP Langer, V (通讯作者)，Army Hosp Res & Referral, Dept Plast & Reconstruct Surg, New Delhi 110010, India.
EM vlangz@gmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
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NR 30
TC 28
Z9 34
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2015
VL 12
IS 4
BP 436
EP 442
DI 10.1111/iwj.12132
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CM2OI
UT WOS:000357520400011
PM 23855645
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Stanger, KM
   Albert, F
   Kneser, U
   Bogdan, C
   Horch, RE
AF Stanger, Katrin M.
   Albert, Frauke
   Kneser, Ulrich
   Bogdan, Christian
   Horch, Raymund E.
TI Management of chronic osteomyelitis of the tibia with life-threatening
   complications under negative pressure wound therapy and isolation of
   Helcococcus kunzii
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Free flap; Helcococcus kunzii; Marjolin ulcer; Negative pressure wound
   therapy; Wound infection
ID PROSTHETIC JOINT INFECTION; SKIN; ABSCESS; GRAFT
AB We report the case of an 86-year-old man with severe wound infection originating from a chronic crural ulcer of the lower limb, which under negative pressure wound therapy led to excessive tissue necrosis and perforation of the anterior tibial artery. A swab taken 10 and 7 days preoperatively was positive for Helcococcus kunzii. H. kunzii has been described as a potentially pathogenic organism. The questions whether the negative pressure wound therapy itself caused the bleeding or the negative pressure wound therapy, which generates an anaerobic atmosphere, has triggered the growth and invasion of the facultative anaerobic bacterium H. kunzii and owing to the infection the artery perforated or whether the bacteria has no influence at all remain currently unanswered. After surgical debridement the signs of infection were completely eliminated, and a free musculocutaneous flap led to rapid healing of the wound. Following which H. kunzii was no longer detectable.
C1 [Stanger, Katrin M.; Horch, Raymund E.] Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Univ Hosp Erlangen, D-91054 Erlangen, Germany.
   [Albert, Frauke; Bogdan, Christian] Univ Erlangen Nurnberg, Univ Hosp Erlangen, Inst Microbiol, Clin Microbiol Immunol & Hyg, D-91054 Erlangen, Germany.
   [Kneser, Ulrich] Heidelberg Univ, Dept Plast & Hand Surg, Dept Hand Plast & Reconstruct Surg, Burn Ctr,BG Trauma Ctr Ludwigshafen, Heidelberg, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   Ruprecht Karls University Heidelberg
RP Stanger, KM (通讯作者)，Univ Klinikum Erlangen, Plast & Handchirurg Klin, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM km@stangermail.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353; Bogdan,
   Christian/0000-0002-2300-0631
CR Bleiziffer O, 2011, J CELL MOL MED, V15, P2452, DOI 10.1111/j.1582-4934.2010.01247.x
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NR 29
TC 12
Z9 14
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2015
VL 12
IS 4
BP 443
EP 446
DI 10.1111/iwj.12133
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CM2OI
UT WOS:000357520400012
PM 23855685
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Abma, E
   Kitshoff, AM
   Vandenabeele, S
   Bosmans, T
   Stock, E
   de Rooster, H
AF Abma, E.
   Kitshoff, A. M.
   Vandenabeele, S.
   Bosmans, T.
   Stock, E.
   de Rooster, H.
TI Treatment of necrotizing fasciitis using negative pressure wound therapy
   in a puppy
SO VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TOXIC-SHOCK-SYNDROME; STREPTOCOCCUS-CANIS
AB A two-month-old German shepherd dog was presented with anorexia, lethargy and left hind limb lameness associated with swelling of the thigh. Clinical findings combined with cytology led to the presumptive diagnosis of necrotizing fasciitis (NF). Extensive debridement was performed and silver-foam-based negative pressure wound therapy (NPWT) was applied. During the first 48 hours, a negative pressure of -75 mmHg was used. Evaluation of the wound demonstrated no progression of necrosis and a moderate amount of granulation tissue formation. A new dressing was placed and a second 48-hour cycle of NPWT was initiated at -125 mmHg. At removal, a healthy wound bed was observed and surgical closure was performed.
   The prompt implementation of NPWT following surgical debridement led to accelerated wound healing without progression of necrosis in this case of canine NF. Negative pressure wound therapy could become an integral part of the management strategy of canine NF, improving the prognosis of this life-threatening disease.
C1 [Abma, E.; Kitshoff, A. M.; Vandenabeele, S.; Bosmans, T.; de Rooster, H.] Univ Ghent, Fac Vet Med, Dept Med & Clin Biol Small Anim, B-9820 Merelbeke, Belgium.
   [Stock, E.] Univ Ghent, Dept Med Imaging & Orthoped Small Anim, Fac Vet Med, B-9820 Merelbeke, Belgium.
C3 Ghent University; Ghent University
RP Abma, E (通讯作者)，Univ Ghent, Fac Vet Med, Dept Med & Clin Biol Small Anim, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM eline.abma@ugent.be
RI Kitshoff, Adriaan/AFS-4979-2022; de Rooster, Hilde/AAX-9497-2020
OI Kitshoff, Adriaan/0000-0001-9657-740X; de Rooster,
   Hilde/0000-0001-8087-256X
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NR 29
TC 1
Z9 1
U1 0
U2 14
PU UNIV GHENT
PI GHENT
PA FACULTY VETERINARY MEDICINE, B-9000 GHENT, BELGIUM
SN 0303-9021
J9 VLAAMS DIERGEN TIJDS
JI Vlaams Diergeneeskd. Tijdschr.
PD MAY-JUN
PY 2015
VL 84
IS 3
BP 147
EP 153
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CM2ZL
UT WOS:000357550800004
DA 2026-07-24
ER
PT J
AU Dumville, JC
   Owens, GL
   Crosbie, EJ
   Peinemann, F
   Liu, ZM
AF Dumville, Jo C.
   Owens, Gemma L.
   Crosbie, Emma J.
   Peinemann, Frank
   Liu, Zhenmi
TI Negative pressure wound therapy for treating surgical wounds healing by
   secondary intention
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; CLOSURE; METAANALYSIS; INFECTIONS;
   SURVIVAL; DISEASE; SURGERY; GROIN
AB Background
   Following surgery, incisions are usually closed by fixing the edges together with sutures (stitches), staples, adhesive glue or clips. This process helps the cut edges heal together and is called 'healing by primary intention'. However, not all incised wounds are closed in this way: where there is high risk of infection, or when there has been significant tissue loss, wounds may be left open to heal from the 'bottom up'. This delayed healing is known as 'healing by secondary intention'. Negative pressure wound therapy (NPWT) is one treatment option for surgical wounds that are healing by secondary intention.
   Objectives
   To assess the effects of negative pressure wound therapy (NPWT) on the healing of surgical wounds healing by secondary intention (SWHSI) in any care setting.
   Search methods
   For this review, in May 2015 we searched the following databases: the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials; Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations; Ovid EMBASE; and EBSCO CINAHL. There were no restrictions based on language or date of publication.
   Selection criteria
   Published or unpublished randomised controlled trials (RCTs) comparing the effects of NPWT with alternative treatments or different types of NPWT in the treatment of SWHSI. We excluded open abdominal wounds from this review as they are the subject of a separate Cochrane review that is in draft.
   Data collection and analysis Two review authors independently performed study selection, risk of bias assessment and data extraction.
   Main results
   We located two studies (69 participants) for inclusion in this review. One study compared NPWT with an alginate dressing in the treatment of open, infected groin wounds. and one study compared NPWT with a silicone dressing in the treatment of excised pilonidal sinus. The trials reported limited outcome data on healing, adverse events and resource use.
   Authors' conclusions
   There is currently no rigorous RCT evidence available regarding the clinical effectiveness of NPWT in the treatment of surgical wounds healing by secondary intention as defined in this review. The potential benefits and harms of using this treatment for this wound type remain largely uncertain.
C1 [Dumville, Jo C.; Liu, Zhenmi] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Owens, Gemma L.; Crosbie, Emma J.] Univ Manchester, Inst Canc Sci, Manchester M13 9PL, Lancs, England.
   [Peinemann, Frank] Univ Cologne, Childrens Hosp, Pediat Oncol & Hematol, D-50931 Cologne, Germany.
C3 University of Manchester; University of Manchester; University of
   Cologne
RP Dumville, JC (通讯作者)，Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
EM jo.dumville@manchester.ac.uk
RI ; Liu, Zhenmi/O-7046-2014; Dumville, Jo/O-7867-2014; /H-2800-2019
OI Davidson, Emma/0000-0003-0284-8630; Liu, Zhenmi/0000-0003-0840-1071;
   Owens, Gemma Louise/0000-0003-3471-4370; Dumville,
   Jo/0000-0002-6546-3685; 
FU School of Nursing, Midwifery and Social Work. University of Manchester,
   UK; National Institute for Health Research [13/89/08]; National
   Institute for Health Research [NIHR-CS-012-009, 13/89/08,
   ACF-2012-06-012] Funding Source: researchfish
FX Internal sources School of Nursing, Midwifery and Social Work.
   University of Manchester, UK. External sources This project was
   supported by the National Institute for Health Research, via Cochrane
   Infrastructure and Cochrane Programme Grant funding (NIHR Cochrane
   Programme Grant 13/89/08 - High Priority Cochrane Reviews in Wound
   Prevention and Treatment) to Cochrane Wounds. The views and opinions
   expressed therein are those of the authors and do not necessarily
   reflect those of the Systematic Reviews Programme, NIHR, NHS or the
   Department of Health, UK.
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NR 63
TC 55
Z9 64
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2015
IS 6
AR CD011278
DI 10.1002/14651858.CD011278.pub2
PG 39
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CM3TE
UT WOS:000357606400074
PM 26042534
OA Green Submitted
DA 2026-07-24
ER
PT J
AU McGarrah, B
AF McGarrah, Barbara
TI Using Negative Pressure Therapy for Wound Healing in the Extremely
   Low-Birth-Weight Infant (Micropreemie)
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE low birth-weight infant; micropreemie; necrotizing enterocolitis (NEC);
   negative pressure wound therapy
ID PEDIATRIC WOUNDS
AB BACKGROUND: The term micropreemie describes an infant born weighing less than 1 pound 12 ounces (800 g) or before 26 weeks' gestation. The gastrointestinal tract of these premature infants is fragile due to developmental immaturity. In this case study, we describe our experience with wound care following surgical intervention for necrotizing enterocolitis in a micropreemie.
   CASE: Baby A is a female who was born at 23 weeks 5 days; she weighed 530 g. On day 12 of life, a sonogram was interpreted as suspicious for intestinal perforation. She underwent exploratory laparotomy with ileal perforation resection and stoma formation. A patch made from porcine small intestine submucosa was used to close the abdomen and negative pressure therapy using an open cell reticulated black foam was placed to assist with wound healing and decrease the need for frequent dressing changes.
   CONCLUSION: Our experience with this case demonstrates the feasibility of negative pressure wound therapy in selected micropreemie infants. Negative pressure therapy was effective in wound closure and decreased the number of dressing changes anticipated using conventional wound care.
C1 [McGarrah, Barbara] Texas Hlth Harris Methodist Ft Worth, Ft Worth, TX 76104 USA.
RP McGarrah, B (通讯作者)，Texas Hlth Harris Methodist Ft Worth, 1300 W Terrell, Ft Worth, TX 76104 USA.
EM mcgarrahba@charter.net
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NR 11
TC 5
Z9 6
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2015
VL 42
IS 4
BP 409
EP 412
DI 10.1097/WON.0000000000000139
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA CM8KV
UT WOS:000357950600006
PM 26135829
DA 2026-07-24
ER
PT J
AU Borejsza-Wysocki, M
   Szmyt, K
   Bobkiewicz, A
   Malinger, S
   Swirkowicz, J
   Hermann, J
   Drews, M
   Banasiewicz, T
AF Borejsza-Wysocki, Maciej
   Szmyt, Krzysztof
   Bobkiewicz, Adam
   Malinger, Stanislaw
   Swirkowicz, Jozef
   Hermann, Jacek
   Drews, Michal
   Banasiewicz, Tomasz
TI Endoscopic vacuum-assisted closure system (E-VAC): case report and
   review of the literature
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Review
DE endoscopic vacuum-assisted wound closure system; Endo-Sponge;
   vacuum-assisted wound closure therapy; eosophageal leakage; rectal
   anastomotic leakage; pancreatico-gastric anastomotic insufficiency
ID ENDO-SPONGE TREATMENT; ANASTOMOTIC LEAKAGE; RISK-FACTORS; ESOPHAGEAL
   LEAKAGE; RECTAL RESECTION; THERAPY; DRAINAGE; SURGERY; PERFORATIONS;
   INSUFFICIENCY
AB Negative pressure wound therapy (NPWT) has become a standard in the treatment of chronic and difficult healing wounds. Negative pressure wound therapy is applied to the wound via a special vacuum-sealed sponge. Nowadays, the endoscopic vacuum-assisted wound closure system (E-VAC) has been proven to be an important alternative in patients with upper and lower intestinal leakage not responding to standard endoscopic and/or surgical treatment procedures. Endoscopic vacuum-assisted wound closure system provides perfect wound drainage and closure of various kinds of defect and promotes tissue granulation. Our experience has shown that E-VAC may significantly improve the morbidity and mortality rate. Moreover, E-VAC may be useful in a multidisciplinary approach from upper gastrointestinal to rectal surgery complications. On the other hand, major limitations of the E-VAC system are the necessity of repeated endoscopic interventions and constant presence of well-trained staff Further, large-cohort studies need to be performed to establish the applicability and effectiveness of E-VAC before routine widespread use can be recommended.
C1 [Borejsza-Wysocki, Maciej; Szmyt, Krzysztof; Bobkiewicz, Adam; Malinger, Stanislaw; Swirkowicz, Jozef; Hermann, Jacek; Drews, Michal; Banasiewicz, Tomasz] Poznan Univ Med Sci, Dept Gen & Endocrine Surg & Gastrointestinal Onco, PL-60355 Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Szmyt, K (通讯作者)，Poznan Univ Med Sci, Dept Gen & Endocrine Surg & Gastrointestinal Onco, 49 Przybyszewskiego St, PL-60355 Poznan, Poland.
EM krzysztof.szmyt@gmail.com
OI Bobkiewicz, Adam/0000-0002-4657-5788
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NR 51
TC 15
Z9 24
U1 0
U2 6
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2015
VL 10
IS 2
BP 299
EP 310
DI 10.5114/wiitm.2015.52080
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CM8RB
UT WOS:000357968200023
PM 26240633
DA 2026-07-24
ER
PT J
AU Klüter, T
   Fitschen-Oestern, S
   Weuster, M
   Fickenscher, H
   Seekamp, A
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AF Klueter, T.
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   Weuster, M.
   Fickenscher, H.
   Seekamp, A.
   Lippross, S.
TI Toxic shock syndrome after open ankle fracture
SO UNFALLCHIRURG
LA German
DT Article
DE Infection risk; Staphylogenic toxins; Open fracture; Sepsis; Negative
   pressure wound therapy
ID PRESSURE WOUND THERAPY; MANAGEMENT; INFECTION
AB The treatment of open fractures is a challenge for the attending surgeon. Depending on the severity, the risk of infection rises up to 50 %. Local infection up to the point of sepsis can develop in spite of surgical and antimicrobial therapy. The present case demonstrates the case of an 18-year-old man who developed toxic shock syndrome (TSS) after an open ankle fracture. This potentially life-threating syndrome usually presents with the main symptoms of fever, hypotension and exanthema and is caused by toxins, such as toxic shock syndrome toxin 1 (TSST-1) and staphylococcal enterotoxins A-D. In some cases it is associated with cardiopulmonary decompensation and can rapidly progress to multiorgan failure.
C1 [Klueter, T.; Fitschen-Oestern, S.; Weuster, M.; Seekamp, A.; Lippross, S.] Univ Klinikum Schleswig Holstein, Klin Unfallchirurg Traumatol, D-24105 Kiel, Germany.
   [Fickenscher, H.] Univ Klinikum Schleswig Holstein, Inst Infektionsmed, D-24105 Kiel, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; University
   of Kiel; Schleswig Holstein University Hospital
RP Klüter, T (通讯作者)，Univ Klinikum Schleswig Holstein, Klin Unfallchirurg Traumatol, Campus Kiel,Arnold Heller Str 3, D-24105 Kiel, Germany.
EM Tim.Klueter@uksh.de
RI Fickenscher, Helmut/J-9655-2019
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NR 15
TC 1
Z9 1
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD JUL
PY 2015
VL 118
IS 7
BP 643
EP 646
DI 10.1007/s00113-014-2659-3
PG 4
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA CM9JY
UT WOS:000358025900020
PM 25312681
DA 2026-07-24
ER
PT J
AU Coccolini, F
   Biffl, W
   Catena, F
   Ceresoli, M
   Chiara, O
   Cimbanassi, S
   Fattori, L
   Leppaniemi, A
   Manfredi, R
   Montori, G
   Pesenti, G
   Sugrue, M
   Ansaloni, L
AF Coccolini, Federico
   Biffl, Walter
   Catena, Fausto
   Ceresoli, Marco
   Chiara, Osvaldo
   Cimbanassi, Stefania
   Fattori, Luca
   Leppaniemi, Ari
   Manfredi, Roberto
   Montori, Giulia
   Pesenti, Giovanni
   Sugrue, Michael
   Ansaloni, Luca
TI The open abdomen, indications, management and definitive closure
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Open abdomen; Peritonitis; Pancreatitis; Trauma; Management; Closure
ID ABDOMINAL COMPARTMENT SYNDROME; INFECTED PANCREATIC NECROSIS;
   NEGATIVE-PRESSURE THERAPY; INTRAABDOMINAL HYPERTENSION; TEMPORARY
   CLOSURE; FASCIAL CLOSURE; BIOLOGIC MESHES; WOUND THERAPY; EXPERIENCE;
   OUTCOMES
AB The indications for Open Abdomen (OA) are generally all those situations in which is ongoing the development an intra-abdominal hypertension condition (IAH), in order to prevent the development of abdominal compartmental syndrome (ACS). In fact all those involved in care of a critically ill patient should in the first instance think how to prevent IAH and ACS. In case of ACS goal directed therapy to achieve early opening and early closure is the key: paradigm of closure shifts to combination of therapies including negative pressure wound therapy and dynamic closure, in order to reduce complications and avoid incisional hernia.
   There have been huge studies and progress in survival of critically ill trauma and septic surgical patients: this in part has been through the great work of pioneers, scientific societies and their guidelines; however future studies and continued innovation are needed to better understand optimal treatment strategies and to define more clearly the indications, because OA by itself is still a morbid procedure.
C1 [Coccolini, Federico; Ceresoli, Marco; Manfredi, Roberto; Montori, Giulia; Ansaloni, Luca] Papa Giovanni XXIII Hosp, Dept Gen Surg, I-24127 Bergamo, Italy.
   [Biffl, Walter] Denver Hlth Med Ctr, Denver, CO USA.
   [Catena, Fausto] Osped Maggiore Parma, Dept Gen Surg, Parma, Italy.
   [Chiara, Osvaldo; Cimbanassi, Stefania] Osped Niguarda Ca Granda, Niguarda Trauma Ctr, Milan, Italy.
   [Fattori, Luca; Pesenti, Giovanni] Azienda Osped San Gerardo, Unita Operat Chirurg Urgenza, Monza, Italy.
   [Leppaniemi, Ari] Univ Helsinki, Dept Abdominal Surg, Helsinki, Finland.
   [Sugrue, Michael] Letterkenny Hosp, Donegal, Ireland.
   [Sugrue, Michael] Donegal Clin Res Acad, Donegal, Ireland.
   [Sugrue, Michael] Univ Coll Hosp, Galway, Ireland.
C3 ASST Papa Giovanni XXIII; Denver Health Medical Center; University of
   Parma; University Hospital of Parma; Ospedale Niguarda Ca' Granda; IRCCS
   Ca Granda Ospedale Maggiore Policlinico; University of Helsinki;
   Ollscoil na Gaillimhe-University of Galway
RP Coccolini, F (通讯作者)，Papa Giovanni XXIII Hosp, Dept Gen Surg, Piazza OMS 1, I-24127 Bergamo, Italy.
EM federico.coccolini@gmail.com
RI Leppäniemi, Ari/GQZ-7991-2022; chiara, osvaldo/R-6151-2018; Coccolini,
   Federico/AAJ-6507-2020; Montori, Giulia/ABF-9661-2020; Ansaloni,
   Luca/AAP-9134-2020; Gunardi, Triana/MGT-0616-2025; Ansaloni,
   Luca/AAJ-6507-2020; Ceresoli, Marco/GMW-5356-2022
OI chiara, osvaldo/0000-0003-2409-2109; Coccolini,
   Federico/0000-0001-6364-4186; Montori, Giulia/0000-0002-7649-2174;
   Ansaloni, Luca/0000-0001-6427-0307; Ansaloni, Luca/0000-0001-6427-0307;
   Ceresoli, Marco/0000-0001-7935-3842
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NR 71
TC 90
Z9 116
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JUL 25
PY 2015
VL 10
AR 32
DI 10.1186/s13017-015-0026-5
PG 10
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA CN4MK
UT WOS:000358404000001
PM 26213565
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chadi, SA
   Vogt, KN
   Knowles, S
   Murphy, PB
   Van Koughnett, JA
   Brackstone, M
   Ott, MC
AF Chadi, Sami A.
   Vogt, Kelly N.
   Knowles, Sarah
   Murphy, Patrick B.
   Van Koughnett, Julie Ann
   Brackstone, Muriel
   Ott, Michael C.
TI Negative pressure wound therapy use to decrease surgical nosocomial
   events in colorectal resections (NEPTUNE): study protocol for a
   randomized controlled trial
SO TRIALS
LA English
DT Article
DE Surgical site infection; Colorectal resection; Negative pressure wound
   therapy; Prevena (TM)
ID VACUUM-ASSISTED CLOSURE; CLOSED INCISION MANAGEMENT; SITE INFECTIONS;
   CARE; PREVENTION
AB Background: Surgical site infections (SSIs) are the second most common form of nosocomial infection. Colorectal resections have high rates of SSIs secondary to the inherently contaminated intraluminal environment. Negative pressure wound therapy dressings have been used on primarily closed incisions to reduce surgical site infections in other surgical disciplines. No randomized control trials exist to support the use of negative pressure wound therapy following elective open colorectal resection to reduce surgical site infection.
   Methods/Design: In this single-center, superiority designed prospective randomized open blinded endpoint controlled trial, patients scheduled for a colorectal resection via a laparotomy will be considered eligible. Patients undergoing laparoscopic resection will be enrolled but only randomized and included if the operation is converted to an open procedure. Exclusion criteria are patients receiving an abdominoperineal resection or a palliative procedure, as well as pregnant patients and those with an adhesive allergy. After informed consent, 300 patients will be randomized to the use of a standard adhesive gauze dressing or to a negative pressure wound device. Patients will be followed in hospital and reassessed on post-operative day 30. The primary outcome measure is SSI within the first 30 post-operative days. Secondary outcomes include the length of hospital stay, the number of return visits related to a potential or actual SSI, cost, and the need for homecare. The primary endpoint analysis follows the intention-to-treat principle.
   Discussion: NEPTUNE is the first randomized controlled trial to investigate the role of incisional negative pressure wound therapy in decreasing the rates of surgical site infections in the abdominal incisions of patients following an elective, open colorectal resection. This low-risk intervention may help decrease the morbidity and costs associated with the development of an SSI in our patients.
C1 [Chadi, Sami A.; Vogt, Kelly N.; Knowles, Sarah; Murphy, Patrick B.; Van Koughnett, Julie Ann; Brackstone, Muriel; Ott, Michael C.] Univ Western Ontario, Dept Surg, Div Gen Surg, London, ON N6A 3K7, Canada.
   [Ott, Michael C.] Univ Western Ontario, LHSC, Schulich Sch Med & Dent, Dept Surg & Surg Oncol, London, ON N6A 5W9, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); London Health Sciences Centre
RP Ott, MC (通讯作者)，Univ Western Ontario, Dept Surg, Div Gen Surg, London, ON N6A 3K7, Canada.
EM michael.ott@lhsc.on.ca
RI Chadi, Sami/DWM-5165-2022; Murphy, Patrick/T-5337-2019
OI Ott, Michael/0000-0002-0816-7089
FU Kinetic Concepts Inc. (San Antonio, TX, USA)
FX The study is funded by an industry grant from Kinetic Concepts Inc. (San
   Antonio, TX, USA).
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NR 20
TC 19
Z9 21
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUL 30
PY 2015
VL 16
AR 322
DI 10.1186/s13063-015-0817-8
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CN7WM
UT WOS:000358645200002
PM 26223227
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kuffler, DP
AF Kuffler, Damien P.
TI Improving the ability to eliminate wounds and pressure ulcers
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID PLATELET-RICH PLASMA; LOW-LEVEL LASER; VACUUM-ASSISTED CLOSURE; DIABETIC
   FOOT ULCERS; NERVE GROWTH-FACTOR; ELECTRICAL-STIMULATION; LIGHT THERAPY;
   SKIN FLAPS; SURVIVAL; TISSUE
AB Pressure ulcers can be initiated by as little as 2 hours of constant pressure on the ski, that blocks blood circulation causing the skin and underlying tissues to die, leading to an open wound that never heals, but continues to grow in diameter and depth, and frequently jeopardizes patients' lives. Despite the application of many diverse techniques, pressure ulcers remain exceptionally difficult to heal because many ulcer elimination techniques have minimal effects, and although other techniques may appear to be effective, the evidence supporting their efficacy is weak. However, increasing evidence indicates that other techniques, such as the application of platelet-rich plasma, vacuum assisted closure, electrical stimulation, and hyperbaric oxygen therapy are effective and should be substituted for the older techniques. This review describes different standard and novel techniques that have been tested for eliminating pressure ulcers and discusses the relative efficacy of these techniques.
C1 Univ Puerto Rico, Inst Neurobiol, 201 Blvd Valle, San Juan, PR 00901 USA.
C3 University of Puerto Rico
RP Kuffler, DP (通讯作者)，Univ Puerto Rico, Inst Neurobiol, 201 Blvd Valle, San Juan, PR 00901 USA.
EM dkuffler@hotmail.com
RI /ABV-7119-2022
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NR 81
TC 15
Z9 16
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2015
VL 23
IS 3
BP 312
EP 317
DI 10.1111/wrr.12284
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CN8MC
UT WOS:000358693900003
PM 25801293
OA Bronze
DA 2026-07-24
ER
PT J
AU Hu, N
   Wu, XH
   Liu, R
   Yang, SH
   Huang, W
   Jiang, DM
   Wu, Q
   Xia, T
   Shao, ZW
   Ye, ZW
AF Hu, Ning
   Wu, Xing-huo
   Liu, Rong
   Yang, Shu-hua
   Huang, Wei
   Jiang, Dian-ming
   Wu, Qiang
   Xia, Tian
   Shao, Zeng-wu
   Ye, Zhe-wei
TI Novel application of vacuum sealing drainage with continuous irrigation
   of potassium permanganate for managing infective wounds of gas gangrene
SO JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL
   SCIENCES
LA English
DT Article
DE vacuum sealing drainage; potassium permanganate; irrigation; gas
   gangrene; trauma
ID OF-THE-LITERATURE; NEGATIVE-PRESSURE; ASSISTED CLOSURE;
   HYPERBARIC-OXYGEN; TISSUE DEFECTS; THERAPY; MANAGEMENT
AB Traumatic gas gangrene is a fatal infection mainly caused by Clostridium perfringens. It is a challenge to manage gas gangrene in open wounds and control infection after debridement or amputation. The aim of the present study was to use vacuum sealing drainage (VSD) with continuous irrigation of potassium permanganate to manage infective wounds of gas gangrene and observe its clinical efficacy. A total of 48 patients with open traumatic gas gangrene infection were included in this study. Amputations were done for 27 patients, and limb salvage procedures were performed for the others. After amputation or aggressive debridement, the VSD system, including polyvinyl alcohol (PVA) foam dressing and polyurethane (PU) film, with continuous irrigation of 1:5000 potassium permanganate solutions, was applied to the wounds. During the follow-up, all the patients healed without recurrence within 8-18 months. There were four complications. Cardiac arrest during amputation surgery occurred in one patient who suffered from severe septic shock. Emergent resuscitation was performed and the patient returned to stable condition. One patient suffered from mixed infection of Staphylococcal aureus, and a second-stage debridement was performed. One patient suffered from severe pain of the limb after the debridement. Exploratory operation was done and the possible reason was trauma of a local peripheral nerve. Three cases of crush syndrome had dialysis treatment for concomitant renal failure. In conclusion, VSD can convert open wound to closed wound, and evacuate necrotic tissues. Furthermore, potassium permanganate solutions help eliminate anaerobic microenvironment and achieve good therapeutic effect on gas gangrene and mixed infection. VSD with continuous irrigation of potassium permanganate is a novel, simple and feasible alternative for severe traumatic open wounds with gas gangrene infection.
C1 [Hu, Ning; Jiang, Dian-ming] Chongqing Med Univ, Affiliated Hosp 1, Inst Orthopaed Res & Educ, Dept Orthopaed Surg, Chongqing 400016, Peoples R China.
   [Wu, Xing-huo; Yang, Shu-hua; Huang, Wei; Wu, Qiang; Xia, Tian; Shao, Zeng-wu; Ye, Zhe-wei] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Orthopaed Surg, Wuhan 430022, Peoples R China.
   [Liu, Rong] Wuhan Univ Sci & Technol, Wuhan Puren Hosp, Dept Orthopaed Surg, Wuhan 430080, Peoples R China.
C3 Chongqing Medical University; Huazhong University of Science &
   Technology; Wuhan University of Science & Technology
RP Ye, ZW (通讯作者)，Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Orthopaed Surg, Wuhan 430022, Peoples R China.
EM ninghu@126.com; wuxinghuo@163.com; 56138779@qq.com
RI Shao, Zengwu/E-9301-2018; Ye, Zhewei/OMM-6832-2025
OI hu, ning/0000-0001-9933-5924; liu, yifei/0009-0002-3294-1668; Ye,
   Zhewei/0000-0002-2730-9820; Liu, Rong/0000-0002-0575-3293
FU National Natural Science Foundation of China [81201393]
FX This study was supported by a grant from the National Natural Science
   Foundation of China (No. 81201393).
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NR 30
TC 17
Z9 18
U1 0
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1672-0733
EI 1993-1352
J9 J HUAZHONG U SCI-MED
JI J. Huazhong Univ. Sci. Tech.-Med.
PD AUG
PY 2015
VL 35
IS 4
BP 563
EP 568
DI 10.1007/s11596-015-1471-9
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CN9JC
UT WOS:000358762100017
PM 26223928
DA 2026-07-24
ER
PT J
AU Vassallo, IM
   Formosa, C
AF Vassallo, Ian Mario
   Formosa, Cynthia
TI Comparing Calcium Alginate Dressings to Vacuum-assisted Closure: A
   Clinical Trial
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE diabetic ulcers; calcium alignate; negative pressure; lower extremity
   wounds; wound healing
ID PRESSURE WOUND THERAPY; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   DISEASE; NEGATIVE-PRESSURE; HIGH-RISK; ULCERS; MULTICENTER; MANAGEMENT;
   ULCERATION; GAUZE
AB Introduction. Several treatment modalities and protocols for arterial wound ulcers are available; however, little consensus exists on which treatment modality provides the best results. The present study sought to compare and evaluate the clinical efficacy of vacuum-assisted closure wound therapy to calcium alginate dressings in the treatment of neuroischemic diabetic foot ulceration. Material and Methods. A single-center quasi-experimental matched subject clinical trial was conducted on 30 subjects living with type 2 diabetes and presenting with a newly diagnosed neuroischemic foot ulceration. Subjects were divided into 2 groups. Group A (n = 15) underwent negative pressure wound therapy and Group B (n = 15) underwent treatment using calcium alginate dressings. Ulcer area and depth were measured during the trial. Results. Both negative pressure therapy and calcium alginate dressings were effective in reducing the surface area and depth of ulcers (P = 0.0001). However, negative pressure was 3.2 times more effective in reducing surface area and 3.78 times more effective in reducing depth of ulcers when compared to calcium alginate (P = 0.0001). Conclusion. Vacuum-assisted closure should be considered as the treatment of choice for neuroischemic ulceration owing to its advantages in reducing surface area and depth when compared to calcium alginate dressings. Improved care could result in improved health outcomes, improved quality of life, and fewer diabetes-related foot complications.
C1 [Vassallo, Ian Mario] Dept Hlth, Valletta, Malta.
   [Formosa, Cynthia] Univ Malta, Fac Hlth Sci, Msida, Malta.
C3 University of Malta
RP Formosa, C (通讯作者)，Univ Malta, Fac Hlth Sci, Msida, Malta.
EM Cynthia.formosa@um.edu.mt
RI ; Formosa, Cynthia/AAC-3182-2020
OI , Abda Ali/0009-0003-8852-5222; Formosa, Cynthia/0000-0002-4251-1621
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NR 45
TC 14
Z9 17
U1 0
U2 14
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2015
VL 27
IS 7
BP 180
EP 190
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CO0CZ
UT WOS:000358819000005
PM 26192736
DA 2026-07-24
ER
PT J
AU Lee, J
   Lee, KJ
   Sun, WY
AF Lee, Jina
   Lee, Kwan Ju
   Sun, Woo Young
TI Necrotizing fasciitis of the breast in a pregnant woman successfully
   treated using negative-pressure wound therapy
SO ANNALS OF SURGICAL TREATMENT AND RESEARCH
LA English
DT Article
DE Necrotizing fasciitis; Breast; Pregnancy; Negative-pressure wound
   therapy
ID SOFT-TISSUE INFECTIONS
AB Necrotizing fasciitis (NF) is a rare and rapidly progressive disease involving the skin, subcutaneous tissue, and deep soft tissue. Although NF can occur any part of the body, the breast is an uncommon primary site for NF, and its occurrence in the breast during pregnancy has never previously been reported. Here, we report the case of a healthy 31-year-old pregnant woman who presented with NF of the left breast that was successfully treated with breast-conserving debridement and secondary wound closure using negative-pressure wound therapy.
C1 [Lee, Jina; Lee, Kwan Ju; Sun, Woo Young] Catholic Univ Korea, Coll Med, Daejeon St Marys Hosp, Dept Surg, Taejon 301723, South Korea.
C3 Catholic University of Korea
RP Sun, WY (通讯作者)，Catholic Univ Korea, Coll Med, Daejeon St Marys Hosp, Dept Surg, 64 Daeheung Ro, Taejon 301723, South Korea.
EM sun2729@naver.com
OI Sun, Woo Young/0000-0002-5447-4266
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NR 10
TC 18
Z9 22
U1 0
U2 7
PU KOREAN SURGICAL SOCIETY
PI SEOUL
PA 3304HO, 101 DONG, BROWNSTONE SEOUL, 335, JUNGMIN-DONG, JUNG-GU, SEOUL,
   100-859, SOUTH KOREA
SN 2288-6575
EI 2288-6796
J9 ANN SURG TREAT RES
JI Ann. Surg. Treat. Res.
PD AUG
PY 2015
VL 89
IS 2
BP 102
EP 106
DI 10.4174/astr.2015.89.2.102
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CO1ET
UT WOS:000358897300009
PM 26236701
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Luo, XB
   Tang, XY
   Ma, YZ
   Zhang, YG
   Fang, SZ
AF Luo, Xiaobo
   Tang, Xiangyu
   Ma, Yuanzheng
   Zhang, Yonggang
   Fang, Shuzhi
TI The efficacy of negative pressure wound therapy in treating sacroiliac
   joint tuberculosis with a chronic sinus tract: a case series
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Sacroiliac joint; Tuberculosis; Negative pressure wound therapy;
   Chemotherapy; Sinus
ID VACUUM-ASSISTED CLOSURE; C-REACTIVE PROTEIN
AB Objective: Tuberculous sacroiliitis with abscess accounts for approximately 50 % of all sacroiliac joint tuberculosis cases. Tuberculous abscesses spread into the sacroiliac joint capsule, subcutaneous tissue, and the skin, and finally becomes a skin sinus. As there are no previous reports about sacroiliac joint tuberculosis with a chronic sinus, we evaluated its clinical characteristics and management by negative pressure wound therapy.
   Methods: A retrospective analysis of 12 patients with sacroiliac joint tuberculosis with chronic sinuses treated between January 2005 and January 2010 was conducted. Patients were treated with negative pressure wound therapy (NPWT). Treatment was divided into three phases: control phase, standard dressing changes daily for 4 weeks; interphase washout period, dressing changes every 3 days for 1 week; and intervention phase, no dressing changes until minimal sinus tract drainage (<5 ml per 24 h). Outcomes including the sinus healing time and the drainage volume were evaluated.
   Results: The mean follow-up was 37.1 months. Sinus healing was observed at an average of 25.25 +/- 7.23 (range, 20-42) days after initial treatment. The mean volume of drainage did not change during the control phase, but decreased from 29.17 +/- 16.63 to 0.25 +/- 0.87 ml in the intervention phase. The mean daily reduction of wound volume, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) in the intervention phase was greater than in the control phase (P < 0.05). Anti-tubercular therapy was administered an average of 14.00 +/- 2.95 (range, 12-18) months. ESR and CRP returned to normal within 3 months after the sinus closure. Bony fusion was observed in 5 (41.7 %) patients, and fibrous ankylosis in the other patients at last follow-up. All patients healed uneventfully.
   Conclusions: Early diagnosis of sacroiliac joint tuberculosis with a chronic sinus can be difficult. NPWT provides better healing of sacroiliac joint tuberculosis with a chronic sinus than standard dressing changes.
C1 [Luo, Xiaobo; Tang, Xiangyu; Zhang, Yonggang] Chinese Peoples Liberat Army, Gen Hosp, Dept Orthoped, Hosp 301, Beijing 100853, Peoples R China.
   [Luo, Xiaobo; Ma, Yuanzheng] Chinese Peoples Liberat Army, Hosp 309, Dept Orthoped, Beijing 100091, Peoples R China.
   [Tang, Xiangyu; Fang, Shuzhi] Chinese Peoples Liberat Army, Hosp 264, Beijing 100853, Peoples R China.
C3 Chinese People's Liberation Army General Hospital
RP Zhang, YG (通讯作者)，Chinese Peoples Liberat Army, Gen Hosp, Dept Orthoped, Hosp 301, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM yonggangzhang23@yeah.net
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NR 33
TC 5
Z9 9
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD AUG 6
PY 2015
VL 10
AR 120
DI 10.1186/s13018-015-0250-4
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CO1IH
UT WOS:000358907300001
PM 26243259
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sziklavari, Z
   Ried, M
   Neu, R
   Schemm, R
   Grosser, C
   Szöke, T
   Hofmann, HS
AF Sziklavari, Zsolt
   Ried, Michael
   Neu, Reiner
   Schemm, Rudolf
   Grosser, Christian
   Szoeke, Tamas
   Hofmann, Hans-Stefan
TI Mini-open vacuum-assisted closure therapy with instillation for
   debilitated and septic patients with pleural empyema
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Vacuum-assisted closure; Negative pressure wound therapy; Instillation;
   Empyema; Minimally invasive
ID OPEN-WINDOW THORACOSTOMY; THORACIC EMPYEMA; POSTPNEUMONECTOMY EMPYEMA;
   INTRATHORACIC APPLICATION; LUNG RESECTION; MANAGEMENT; PERSISTENT;
   SURGERY; DEVICE; OPTION
AB OBJECTIVES: This prospective study is an evaluation of the mini-open vacuum-assisted closure with instillation (Mini-VAC-Instill) therapy for the treatment of complicated pleural empyema.
   METHODS: We investigated septic patients in poor general physical condition (Karnofsky index <= 50%) with multimorbidity and/or immunosuppression who were treated by minimally invasive intrathoracic VAC-Instill therapy without the insertion of an open-window thoracostomy (OWT) between December 2012 and November 2014. All patients underwent mini-thoracotomy with position of a tissue retractor, surgical debridement and local decortication. Surgery was followed by intrathoracic vacuum therapy including periodic instillation using antiseptics. The VAC dressings were changed under general anaesthesia and the chest wall was closed during the same hospital stay. All patients received systemic antibiotic therapy.
   RESULTS: Fifteen patients (13 males, median age: 71 years) underwent intrathoracic Mini-VAC-Instill dressings for the management of pleural empyema without bronchopleural fistula. The median length of vacuum therapy was 9 days (5-25 days) and the median number of VAC changes per patient was 1 (1-5). In-hospital mortality was 6.7% (n = 1) and was not related to Mini-VAC-Instill therapy or intrathoracic infection. Control of intrathoracic infection and closure of the chest cavity was achieved in 85.7% of surviving patients (12 of 14). After the follow-up at an average of 13.2 months (range, 3-25 months), we observed recurrence once, 21 days after discharge. Two patients died in the late postoperative period (Day 43 and Day 100 after discharge) of fulminant urosepsis and carcinoma-related multiorgan failure, respectively. Analysis of the follow-up interviews in the outpatient clinic showed a good quality of life and a subjectively good long-term aesthetic result.
   CONCLUSIONS: Mini-VAC-Instill therapy is an upgrade of Mini-VAC, which guarantees the advantage of an open treatment, including flushing but without OWT. This procedure is minimally invasive, highly compatible especially with patients in poor general condition and may be an alternative to the OWT in selected patients. Consequently, a very short course of therapy results in good patient acceptance.
C1 [Sziklavari, Zsolt; Schemm, Rudolf; Grosser, Christian; Szoeke, Tamas; Hofmann, Hans-Stefan] Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, D-93049 Regensburg, Germany.
   [Ried, Michael; Neu, Reiner; Hofmann, Hans-Stefan] Univ Regensburg, Dept Thorac Surg, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Sziklavari, Z (通讯作者)，Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, Prufeningerstr 86, D-93049 Regensburg, Germany.
EM zsolt.sziklavari@barmherzige-regensburg.de
RI Ried, Michael/AAC-4518-2022; Sziklavari, Zsolt/AGI-2440-2022
OI Ried, Michael/0000-0002-2365-4803; 
CR Al-Mufarrej F, 2010, SURG TODAY, V40, P711, DOI 10.1007/s00595-008-4096-9
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NR 25
TC 18
Z9 28
U1 0
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD AUG
PY 2015
VL 48
IS 2
BP E9
EP E16
DI 10.1093/ejcts/ezv186
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA CO7CM
UT WOS:000359315100001
PM 26017017
OA Bronze
DA 2026-07-24
ER
PT J
AU Tavusbay, C
   Genc, H
   Cin, N
   Kar, H
   Kamer, E
   Atahan, K
   Haciyanli, M
AF Tavusbay, Cengiz
   Genc, Hudai
   Cin, Necat
   Kar, Haldun
   Kamer, Erdinc
   Atahan, Kemal
   Haciyanli, Mehmet
TI Use of a vacuum-assisted closure system for the management of
   enteroatmospheric fistulae
SO SURGERY TODAY
LA English
DT Article
DE Enteroatmospheric; Fistula; Open abdomen; Abdominal complications;
   Peritonitis; Vacuum-assisted closure
ID OPEN ABDOMEN
AB The aim of this study was to analyze the management of enteroatmospheric fistulae (EAF) in an open abdomen using vacuum-assisted closure (VAC) therapy.
   Eighteen patients (ten male/eight female) were treated in our surgical department for the management of EAF. VAC therapy was used to manage both complex and open abdominal wounds and for effluent control in all patients except one until definitive surgery could be performed or spontaneous closure of the EAF occurred.
   The median age of the patients was 61.1 years (range 29-84 years). Their average hospital stay was 88.89 days (range 22-129 days). The median number of VAC applications was 22.5, and the median duration of VAC applications was 43.6 days (range 14-114 days). Non-surgical spontaneous closure of the fistulae with negative pressure wound therapy could be achieved in four patients. In the other six patients, after the EAF were controlled with VAC therapy, definitive surgery was performed. Primary fascial repair was performed in two patients, and the component separation technique was synchronously performed in another two patients. Ventral hernia repair using polypropylene mesh was performed in a patient 1 year after discharge from the hospital. One patient was discharged with skin grafting plus ileostomy after the EAF was managed with VAC therapy. Eight patients (44.4 %) died due to intraabdominal infections and sepsis, which could not be controlled despite all precautions. No VAC-related complications were observed in this study.
   A VAC system can be successfully used for wound management in the control of fistula effluent in patients with an EAF in an open abdomen until spontaneous fistula closure occurs or definitive fistula surgery can be performed.
C1 [Tavusbay, Cengiz; Genc, Hudai; Cin, Necat; Kar, Haldun; Kamer, Erdinc; Atahan, Kemal; Haciyanli, Mehmet] Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Surg, TR-35360 Izmir, Turkey.
C3 Izmir Ataturk Training & Research Hospital; Izmir Katip Celebi
   University
RP Kamer, E (通讯作者)，Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Surg, TR-35360 Izmir, Turkey.
EM erdinc.kamer@gmail.com
RI TAVUSBAY, Cengiz/N-9236-2014; kar, haldun/R-6845-2019; HACIYANLI,
   MEHMET/P-6709-2019; Kamer, Erdinc/A-5245-2009
OI Kamer, Erdinc/0000-0002-5084-5867
CR Aguila DJ, 2011, J AM COLL SURGEONS, V213, pE17, DOI 10.1016/j.jamcollsurg.2011.06.422
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NR 25
TC 29
Z9 36
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD SEP
PY 2015
VL 45
IS 9
BP 1102
EP 1111
DI 10.1007/s00595-014-1020-3
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CP1UE
UT WOS:000359660900004
PM 25163660
DA 2026-07-24
ER
PT J
AU Aviki, EM
   Batalden, RP
   del Carmen, MG
   Berkowitz, LR
AF Aviki, Emeline M.
   Batalden, Rebecca Posthuma
   del Carmen, Marcela G.
   Berkowitz, Lori R.
TI Vacuum-Assisted Closure for Episiotomy Dehiscence
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
AB BACKGROUND:Episiotomy dehiscence can result in a large vulvovaginal defect not amenable to delayed primary closure.CASE:A 26-year-old woman who underwent a forceps-assisted vaginal delivery with mediolateral episiotomy presented on postpartum day 5 with complete wound breakdown. Surgical exploration of the wound revealed a defect extending from the perineum into the vagina and deep into the ischiorectal fossa with poor tissue quality not amenable to a timely delayed primary closure. A vacuum-assisted closure device was used in lieu of traditional wound preparation and resulted in wound closure after 11 days of vacuum-assisted wound therapy.CONCLUSION:A vacuum-assisted closure device may be appropriate in cases of complex episiotomy breakdown and may expedite wound healing in the outpatient setting.
C1 [Aviki, Emeline M.] Massachusetts Gen Hosp, Vincent Obstet & Gynecol, Boston, MA 02114 USA.
   Harvard Univ, Sch Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School
RP Aviki, EM (通讯作者)，Massachusetts Gen Hosp, Vincent Obstet & Gynecol, 55 Fruit St, Boston, MA 02114 USA.
EM eaviki@partners.org
OI Aviki, Emeline/0000-0003-0891-9399
CR Dudley LM, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008977.pub2
   Frankman EA, 2009, AM J OBSTET GYNECOL, V200, DOI 10.1016/j.ajog.2008.11.022
   Milcheski Dimas André, 2013, Rev. Col. Bras. Cir., V40, P312
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Narducci F, 2012, EUR J OBSTET GYN R B, V161, P199, DOI 10.1016/j.ejogrb.2011.12.016
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   Uygur D, 2004, AUST NZ J OBSTET GYN, V44, P244, DOI 10.1111/j.1479-828X.2004.00187.x
NR 8
TC 6
Z9 7
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD SEP
PY 2015
VL 126
IS 3
BP 530
EP 533
DI 10.1097/AOG.0000000000000785
PG 4
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CP2KH
UT WOS:000359705400012
PM 25923027
DA 2026-07-24
ER
PT J
AU Listewnik, MJ
   Sielicki, P
   Mokrzycki, K
   Biskupski, A
   Brykczynski, M
AF Listewnik, Mariusz J.
   Sielicki, Piotr
   Mokrzycki, Krzysztof
   Biskupski, Andrzej
   Brykczynski, Miroslaw
TI The Use of Vacuum-Assisted Closure in Purulent Complications and
   Difficult-To-Heal Wounds in Cardiac Surgery
SO ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE cardiac surgery; vacuum assisted therapy; wound infection
ID RISK-FACTORS; POSTOPERATIVE MEDIASTINITIS; INFECTIONS; THERAPY; SITE
AB Background. Sternal wound infections are a serious and potentially fatal complication of cardiac surgery.
   Objectives. The aim of the study was to analyze the results of using the vacuum-assisted closure (VAC) system over a 4-year period.
   Material and Methods. Quantitative VAC performance data from a retrospective review of a consecutive cohort of 47 patients treated with VAC for post-cardiac surgery wound complications were collected and statistically analyzed. In the study group 35 patients developed infections of the post-operative chest wound. In 12 other patients wound dehiscence was observed, but repeated cultures did not reveal the presence of any bacteria.
   Results. The statistical analysis identified the following as significant risk factors: age, female sex, being overweight, a high total logistic EuroScore, the use of both internal thoracic arteries for bypass grafting, and diabetes. In the wound negative culture group the total length of hospital stay was significantly shorter than in the wound positive culture group. Mortality in this group was 0.0% vs. 5.7% in the wound positive culture group. In the study material, Gram-negative bacteria were responsible for 77% of the post-operative wound infections, with only 14% Gram-positive wound cultures. No complications were related to VAC use.
   Conclusions. The use of negative-pressure wound therapy with other concomitant surgical procedures is a good method of treating infected wounds as well as non-contaminated dehiscence of the wound and sternum. Considering that most of the infections within the authors' department are caused by Gram-negative bacteria, it would be beneficial to consider modifying the model of preventive antibiotic treatment to cover the Gram-negative spectrum in addition to the Gram-positive bacteria currently targeted.
C1 [Listewnik, Mariusz J.; Sielicki, Piotr; Mokrzycki, Krzysztof; Biskupski, Andrzej; Brykczynski, Miroslaw] Pomeranian Med Univ, Dept Cardiac Surg, PL-70111 Szczecin, Poland.
C3 Pomeranian Medical University
RP Listewnik, MJ (通讯作者)，Pomeranian Med Univ, Dept Cardiac Surg, Powstancow Wielkopolskich 72, PL-70111 Szczecin, Poland.
EM sindbaad@poczta.onet.pl
RI Biskupski, Andrzej/J-2941-2014
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   Zeitani J, 2004, ANN THORAC SURG, V77, P672, DOI 10.1016/S0003-4975(03)01594-7
NR 15
TC 11
Z9 14
U1 1
U2 7
PU WROCLAW MEDICAL UNIV
PI WROCLAW
PA UL K MARCINKOWSKIEGO 2-6, WROCLAW, 50-368, POLAND
SN 1899-5276
EI 2451-2680
J9 ADV CLIN EXP MED
JI Adv. Clin. Exp. Med.
PD MAY-JUN
PY 2015
VL 24
IS 4
BP 643
EP 650
DI 10.17219/acem/28111
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CQ0LL
UT WOS:000360287300012
PM 26469109
OA gold
DA 2026-07-24
ER
PT J
AU Ng, ZY
   Salgado, CJ
   Moran, SL
   Chim, H
AF Ng, Zhi Yang
   Salgado, Christopher J.
   Moran, Steven L.
   Chim, Harvey
TI Soft Tissue Coverage of the Mangled Upper Extremity
SO SEMINARS IN PLASTIC SURGERY
LA English
DT Article
DE upper extremity; hand; injury; soft tissue flap
ID ANTEROLATERAL THIGH FLAP; RECONSTRUCTION; TRAUMA; REPLANTATION;
   MANAGEMENT; AMPUTATION; SELECTION
AB Mangled upper extremity injuries usually involve high-impact trauma with crushing and tearing of the limb and its associated soft tissue structures. Such trauma is particularly mutilating because of the nature of the injury and the involvement of structures vital for proper function. Although advancements in flap technique and improvements in bone fixation methods have enabled good functional and clinical outcomes in limb salvage reconstruction, this remains a challenging area. Attempts at limb preservation should be fully exhausted before consideration is given for amputation, which results in significantly decreased function. Here the authors focus on the various modalities of soft tissue coverage available including allogenic substitutes, the adjunctive use of negative pressure wound therapy, and the design and utilization of flaps to address various defect configurations for the goals of wound healing, aesthetics, and functional restoration in the mangled upper extremity.
C1 [Ng, Zhi Yang] Alexandra Hosp, Dept Orthopaed Surg, Singapore, Singapore.
   [Salgado, Christopher J.; Chim, Harvey] Univ Miami, Miller Sch Med, Div Plast Surg, Miami, FL 33136 USA.
   [Moran, Steven L.] Mayo Clin, Div Plast Surg, Rochester, MN USA.
C3 University of Miami; Mayo Clinic
RP Chim, H (通讯作者)，Univ Miami, Miller Sch Med, Dept Surg, Div Plast Surg, Clin Res Bldg,1120 NW 14th St,4th Floor, Miami, FL 33136 USA.
EM harveychim@yahoo.com
RI Ng, Zhi Yang/N-8251-2018
OI Ng, Zhi Yang/0000-0003-0538-3066
CR Bastidas N, 2009, ANN PLAS SURG, V62, P410, DOI 10.1097/SAP.0b013e318184ab2f
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NR 38
TC 18
Z9 22
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1535-2188
J9 SEMIN PLAST SURG
JI Semin. Plast. Surg.
PD FEB
PY 2015
VL 29
IS 1
BP 48
EP 54
DI 10.1055/s-0035-1544170
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CQ4BG
UT WOS:000360548500008
PM 25685103
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Prince, N
   Blackburn, S
   Murad, G
   Mast, B
   Sapountzis, S
   Shaw, C
   Werning, J
   Singhal, D
AF Prince, Noah
   Blackburn, Spiros
   Murad, Gregory
   Mast, Bruce
   Sapountzis, Stamatis
   Shaw, Christiana
   Werning, John
   Singhal, Dhruv
TI Vacuum-Assisted Closure Therapy to the Brain A Safe Method for Wound
   Temporization in Composite Scalp and Calvarial Defects
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT 57th Annual Meeting of the
   South6eastern-Society-of-Plastic-and-Reconstructive-Surgeons
CY JUN 08-12, 2014
CL Nassau, BAHAMAS
SP SE Soc Plast & Reconstruct Surg
ID INFECTIONS; DURA
AB Background
   When composite scalp and calvarial defects with dural or cortical brain exposure are encountered, active infection or indeterminate oncologic margins complicate the timing of scalp reconstruction. The purpose of this study was to evaluate the safety and efficacy of vacuum-assisted closure (VAC) therapy as a temporizing measure in these complex scalp defects with dural or cortical brain exposure and a hostile local wound environment.
   Methods
   From December 2012 to December 2013, all composite scalp and calvarial defects reconstructed by the senior author (D.S.) were reviewed and 10 cases were identified. Five of these cases were temporized with VAC therapy. The medical records of these patients were reviewed.
   Results
   Five patients (mean age, 66.2 years) with composite scalp and calvarial defects were temporized with VAC therapy. The indications for delay included gross wound infection in 4 patients and an indeterminate intraoperative oncologic margin. The average size of the scalp and calvarial defects measured 123 and 49 cm(2), respectively. One patient underwent VAC therapy over exposed cortical brain with a dural defect measuring 25 cm(2). The average time between the initial operation and definitive reconstruction was 4.8 days. The average daily VAC output was 74 mL. Reconstructive methods included 1 free flap, 2 scalp rotational advancement flaps, and readvancement of 2 prior free flaps. At an average follow-up of 32 weeks, 1 patient developed a subcentimeter postoperative wound breakdown that was treated successfully with an incisional VAC.
   Conclusions
   We found the use of VAC therapy applied directly to the dura or cortical brain as a safe and effective technique for short-term wound temporization in the setting of indeterminate oncologic margins or active infection.
C1 [Prince, Noah; Mast, Bruce; Singhal, Dhruv] Univ Florida, Dept Surg, Div Plast & Reconstruct Surg, Sch Med, Gainesville, FL 32610 USA.
   [Blackburn, Spiros; Murad, Gregory] Univ Florida, Sch Med, Dept Neurosurg, Gainesville, FL 32610 USA.
   [Sapountzis, Stamatis] China Med Univ Hosp, Dept Plast Surg, Taichung, Taiwan.
   [Shaw, Christiana] Univ Florida, Sch Med, Dept Surg, Div Surg Oncol, Gainesville, FL 32610 USA.
   [Werning, John] Univ Florida, Sch Med, Dept Otolaryngol, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; China Medical
   University Taiwan; China Medical University Hospital - Taiwan; State
   University System of Florida; University of Florida; State University
   System of Florida; University of Florida
RP Singhal, D (通讯作者)，Univ Florida, Dept Surg, Div Plast & Reconstruct Surg, POB 100138, Gainesville, FL 32610 USA.
EM dhruv.singhal@surgery.ufl.edu
OI Shaw, Christiana/0000-0002-7522-0556; BLACKBURN,
   SPIROS/0000-0003-2902-5079
CR Bartels CG, 2001, HAUTARZT, V52, P653
   Colwell AS, 2004, ANN PLAS SURG, V52, P49, DOI 10.1097/01.sap.0000099960.68038.53
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Hardwicke Joseph, 2006, Int J Low Extrem Wounds, V5, P101, DOI 10.1177/1534734606288576
   Khan MAA, 2010, J PLAST RECONSTR AES, V63, P2168, DOI 10.1016/j.bjps.2010.03.017
   Marathe US, 2004, LARYNGOSCOPE, V114, P961, DOI 10.1097/00005537-200406000-00001
   Powers AK, 2013, J NEUROSURG, V118, P302, DOI 10.3171/2012.10.JNS112241
   Subotic U, 2011, NEUROSURGERY, V68, pE1481, DOI 10.1227/NEU.0b013e318210c7fb
NR 8
TC 17
Z9 19
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2015
VL 74
SU 4
BP S218
EP S221
DI 10.1097/SAP.0000000000000374
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA CQ4IC
UT WOS:000360567200009
PM 25978553
DA 2026-07-24
ER
PT J
AU Dumville, JC
   Land, L
   Evans, D
   Peinemann, F
AF Dumville, Jo C.
   Land, Lucy
   Evans, Debra
   Peinemann, Frank
TI Negative pressure wound therapy for treating leg ulcers
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; ULCERATION; EFFICACY; TRIAL; METAANALYSIS;
   PREVALENCE; IMPACT; CARE
AB Background
   Leg ulcers are open skin wounds that occur between the ankle and the knee that can last weeks, months or even years and are a consequence of arterial or venous valvular insufficiency. Negative pressure wound therapy (NPWT) is a technology that is currently used widely in wound care and is promoted for use on wounds. NPWT involves the application of a wound dressing to the wound, to which a machine is attached. The machine applies a carefully controlled negative pressure (or vacuum), which sucks any wound and tissue fluid away from the treated area into a canister.
   Objectives
   To assess the effects of negative pressure wound therapy (NPWT) for treating leg ulcers in any care setting.
   Search methods
   For this review, in May 2015 we searched the following databases: the Cochrane Wounds Group Specialised Register (searched 21 May 2015); the Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library 2015, Issue 4); Ovid MEDLINE (1946 to 20 May 2015); Ovid MEDLINE (In-Process & Other Non-Indexed Citations 20 May 2015); Ovid EMBASE (1974 to 20 May 2015); EBSCO CINAHL (1982 to 21 May 2015). There were no restrictions based on language or date of publication.
   Selection criteria
   Published or unpublished randomized controlled trials (RCTs) comparing the effects of NPWT with alternative treatments or different types of NPWT in the treatment of leg ulcers.
   Data collection and analysis
   Two review authors independently performed study selection, risk of bias assessment and data extraction.
   Main results
   We included one study, with 60 randomized participants, in the review. The study population had a range of ulcer types that were venous arteriolosclerotic and venous/arterial in origin. Study participants had recalcitrant ulcers that had not healed after treatment over a six-month period. Participants allocated to NPWT received continuous negative pressure until they achieved 100% granulation (wound preparation stage). A punch skin-graft transplantation was conducted and the wound then exposed to further NPWT for four days followed by standard care. Participants allocated to the control arm received standard care with dressings and compression until 100% granulation was achieved. These participants also received a punch skin-graft transplant and then further treatment with standard care. All participants were treated as in-patients until healing occurred.
   There was low quality evidence of a difference in time to healing that favoured the NPWT group: the study reported an adjusted hazard ratio of 3.2, with 95% confidence intervals (CI) 1.7 to 6.2. The follow-up period of the study was a minimum of 12 months.
   There was no evidence of a difference in the total number of ulcers healed (29/30 in each group) over the follow-up period; this finding was also low quality evidence. There was low quality evidence of a difference in time to wound preparation for surgery that favoured NPWT (hazard ratio 2.4, 95% CI 1.2 to 4.7).
   Limited data on adverse events were collected: these provided low quality evidence of no difference in pain scores and Euroqol (EQ5D) scores at eight weeks after surgery.
   Authors' conclusions
   There is limited rigorous RCT evidence available concerning the clinical effectiveness of NPWT in the treatment of leg ulcers. There is some evidence that the treatment may reduce time to healing as part of a treatment that includes a punch skin graft transplant, however, the applicability of this finding may be limited by the very specific context in which NPWT was evaluated. There is no RCT evidence on the effectiveness of NPWT as a primary treatment for leg ulcers.
C1 [Dumville, Jo C.] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Land, Lucy] Birmingham City Univ, Ctr Hlth & Social Care Res, Birmingham, W Midlands, England.
   [Evans, Debra] Birmingham City Univ, Div Community Hlth & Social Work, Birmingham, W Midlands, England.
   [Peinemann, Frank] Univ Cologne, Childrens Hosp, Pediat Oncol & Hematol, D-50931 Cologne, Germany.
C3 University of Manchester; Birmingham City University; Birmingham City
   University; University of Cologne
RP Dumville, JC (通讯作者)，Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
EM jo.dumville@manchester.ac.uk
RI /H-2800-2019; Dumville, Jo/O-7867-2014
OI Land, Lucy/0000-0001-8634-8056; Dumville, Jo/0000-0002-6546-3685
FU School of Nursing, Midwifery and Social Work, University of Manchester,
   UK; National Institute for Health Research, via Cochrane Infrastructure
   [13/89/08]; National Institute for Health Research, via Cochrane
   Programme Grant [13/89/08]; National Insitiute for Health Research
   (NIHR); National Institute for Health Research [13/89/08] Funding
   Source: researchfish
FX Internal sources School of Nursing, Midwifery and Social Work,
   University of Manchester, UK. External sources This project was
   supported by the National Institute for Health Research, via Cochrane
   Infrastructure and Cochrane Programme Grant funding (NIHR Cochrane
   Programme Grant 13/89/08 - High Priority Cochrane Reviews in Wound
   Prevention and Treatment) to Cochrane Wounds. The views and opinions
   expressed therein are those of the authors and do not necessarily
   reflect those of the Systematic Reviews Programme, NIHR, NHS or the
   Department of Health., UK. The National Insitiute for Health Research
   (NIHR) is the sole funder of the Cochrane Wounds Group, UK.
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NR 60
TC 64
Z9 72
U1 2
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2015
IS 7
AR CD011354
DI 10.1002/14651858.CD011354.pub2
PG 38
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CQ5MF
UT WOS:000360647800063
PM 26171910
OA Bronze
DA 2026-07-24
ER
PT J
AU Schwartz, JA
   Fuller, A
   Avdagic, E
   Gendics, C
   Lantis, JC
AF Schwartz, J. A.
   Fuller, A.
   Avdagic, E.
   Gendics, C.
   Lantis, J. C.
TI Use of NPWT with and without Soft Port technology in infected foot
   wounds undergoing partial diabetic foot amputation
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; chronic wounds; pressure ulcers;
   diabetic foot ulcers; amputation
ID THERAPY; TRIAL
AB Objective: Negative pressure wound therapy (NPWT) has previously been shown to be effective in closing diabetic foot wounds that have undergone amputation over a 16-week period. For patients with plantar foot wounds, NPWT is a key therapy. An alternative NPWT with and without a novel soft, flexible port system needs to be evaluated for its comparable efficacy. Our objective was to show the non-inferiority of an alternative negative pressure system, and in a small subset, a novel foam dressing system.
   Method: We performed a single centre prospective study of patients with diabetes undergoing open bone resection in the foot for acutely infected wounds. Wounds were treated with NPWT/Soft Port technology (SPT), for 112 days or until primary closure or the wound was deemed ready for delayed primary closure. Rate of closure and quality of life were analysed. A previously published cohort was used as a control.
   Results: Of the 30 patients initially recruited, 29 met eligibility requirements and had NPWT applied a median of 2 days postoperatively. There were seven patients (24%) who had delayed primary closure (mean=58 days) and 52% had sufficient progress to change in treatment (15/29; mean=62 days). Only one patient reached the 112-day mark without sufficient progress to be closed. The primary method of delayed primary closure was split-thickness skin graft. There was a reduction in wound area 56.3% (initial mean area=17.4cm(2) to final mean area=7.6 cm(2); p=0.001) at the end of treatment (mean=58.7 days) reduced to 4.3cm(2) a 67.2% reduction (p=0.004) at the end of study (112 days).
   Conclusion: The alternative NPWT and the SPT was well tolerated and effective in the population in aggregate. There was no inferiority between the two technologies. The aggregate closure or progression to be ready for closure rate of 75% at 69 days compares very favourably with previously published data for NPWT in this population of 56% at 56 days (range: 26-92 days). Both cohorts did significantly better than previously published standard of care closure rates of 39% at 77 days.
C1 [Schwartz, J. A.; Fuller, A.; Avdagic, E.] St Lukes Roosevelt Hosp, New York, NY 10025 USA.
   [Lantis, J. C.] St Lukes Roosevelt Hosp, Dept Surg, New York, NY USA.
   [Lantis, J. C.] St Lukes Roosevelt Hosp, Vasc Endovasc Surg, New York, NY USA.
   [Fuller, A.; Avdagic, E.; Gendics, C.] Mt Sinai, New York, NY 10025 USA.
C3 Mount Sinai West; Mount Sinai Morningside; Mount Sinai Morningside;
   Mount Sinai West; Mount Sinai West; Mount Sinai Morningside
RP Schwartz, JA (通讯作者)，St Lukes Roosevelt Hosp, New York, NY 10025 USA.
EM jlantis@chpnet.org
FU Smith Nephew; Acelity; Macrocure; Manukamed
FX J.C. Lantis is a paid consultant for Smith & Nephew, Acelity, Macrocure
   and Manukamed. This trial as supported by an institutional grant to St
   Luke's and Roosevelt Hospital sponsored by Smith & Nephew. The outcome
   of the trial had no bearing on the condition of the grant. No
   investigator holds an equity position in Smith & Nephew. C. Gendics is a
   paid consultant of Acelity.
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Joseph E, 2000, WOUNDS, V12, P60
   McCallon S.K., 2000, OSTOMY WOUND MANAG, V46, P8
   Rahmanian-Schwarz A, 2012, BURNS, V38, P573, DOI 10.1016/j.burns.2011.10.010
NR 4
TC 6
Z9 7
U1 0
U2 10
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2015
VL 24
IS 9
SU S
BP S4
EP S12
DI 10.12968/jowc.2015.24.Sup9.S4
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CQ5NK
UT WOS:000360651600002
PM 26352284
DA 2026-07-24
ER
PT J
AU Semsarzadeh, NN
   Tadisina, KK
   Maddox, J
   Chopra, K
   Singh, DP
AF Semsarzadeh, Nina N.
   Tadisina, Kashyap K.
   Maddox, John
   Chopra, Karan
   Singh, Devinder P.
TI Closed Incision Negative-Pressure Therapy Is Associated with Decreased
   Surgical-Site Infections: A Meta-Analysis
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; WOUND-THERAPY;
   MANAGEMENT-SYSTEM; CARE; SURGERY; PREVENTION; DEHISCENCE; DRESSINGS
AB Background: Negative-pressure therapy has recently been used over closed incisions to decrease surgical-site occurrences, including infection and dehiscence. A meta-analysis was performed to evaluate the effectiveness of closed incision negative-pressure therapy in lowering the incidence of surgical-site infections compared with standard dressings.
   Methods: A literature search was conducted to find publications comparing closed incision negative-pressure therapy to standard incisional care. A fixed-effects model was used to assess between-study and between-incision location subgroup heterogeneity and effect size. Funnel plots were used to assess publication bias.
   Results: The overall weighted average rates of surgical-site infection in the closed incision negative-pressure therapy and control groups were 6.61 percent and 9.36 percent, respectively. This reflects a relative reduction in surgical site infection rate of 29.4 percent. A decreased likelihood of surgical-site infection was evident in the closed incision negative-pressure therapy group compared with the control group across all studies, and across all four incision location subgroups. Across all studies, odds of surgical-site infections decreased 0.564 (p < 0.00001). After excluding groin incision studies because of heterogeneity following sensitivity analysis, the odds of surgical-site infection decrease was still 0.496 (p < 0.00001). In addition, overall rates of dehiscence in closed incision negative-pressure therapy and control groups were 5.32 percent and 10.68 percent, respectively.
   Conclusions: The results of this meta-analysis suggest that closed incision negative-pressure therapy is a potentially effective method for reducing surgical-site infections. It also appears that closed incision negative-pressure therapy may be associated with a decreased incidence of dehiscence, but the published data available were too heterogeneous to perform meta-analysis.
C1 [Singh, Devinder P.] Univ Maryland, Sch Med, Div Plast Surg, Baltimore, MD 21201 USA.
   Johns Hopkins Univ Hosp, Dept Plast & Reconstruct Surg, Baltimore, MD 21287 USA.
   Walter Reed Natl Mil Med Ctr, Dept Gen Surg, Bethesda, MD USA.
   Univ Illinois, Coll Med, Chicago, IL USA.
C3 University System of Maryland; University of Maryland Baltimore; Johns
   Hopkins University; Johns Hopkins Medicine; Walter Reed National
   Military Medical Center; University of Illinois System; University of
   Illinois Chicago; University of Illinois Chicago Hospital
RP Singh, DP (通讯作者)，Univ Maryland, Sch Med, Div Plast Surg, 22 S Greene St, Baltimore, MD 21201 USA.
EM dsingh@smail.umaryland.edu
RI Singh, Devinder/AAN-4716-2021
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NR 52
TC 125
Z9 136
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2015
VL 136
IS 3
BP 592
EP 602
DI 10.1097/PRS.0000000000001519
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CQ5ZI
UT WOS:000360683800001
PM 26313829
DA 2026-07-24
ER
PT J
AU Rhee, SM
   Valle, MF
   Wilson, LM
   Lazarus, G
   Zenilman, JM
   Robinson, KA
AF Rhee, Susan M.
   Valle, M. Frances
   Wilson, Lisa M.
   Lazarus, Gerald
   Zenilman, Jonathan M.
   Robinson, Karen A.
TI Negative pressure wound therapy technologies for chronic wound care in
   the home setting: A systematic review
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID EXTRACELLULAR-MATRIX; DERMAL FIBROBLASTS; SKIN; REPAIR; ANGIOGENESIS;
   CONTRACTION; ELASTICITY; EXPRESSION; SCAFFOLDS; RESPONSES
AB The use of negative pressure wound therapy (NPWT) is increasing in both the inpatient and outpatient settings. We conducted a systematic review on the efficacy and safety of NPWT for the treatment of chronic wounds in the home setting. We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and the Cumulative Index to Nursing and Allied Health Literature, up to June 2014. Two independent reviewers screened search results. Seven studies met our criteria for inclusion. Six of the studies compared NPWT devices to other wound care methods and one study compared two different NPWT technologies. Data were limited by variability in the types of comparator groups, methodological limitations, and poor reporting of outcomes. We were unable to draw conclusions about the efficacy or safety of NPWT for the treatment of chronic wounds in the home setting due to the insufficient evidence. Consensus is needed on the methods of conducting and reporting wound care research so that future studies are able inform decisions about the use of NPWT in the home environment for chronic wounds.
C1 [Rhee, Susan M.; Zenilman, Jonathan M.] Johns Hopkins Univ, Div Infect Dis, Sch Med, Johns Hopkins Bayview Med Ctr, Baltimore, MD 21218 USA.
   [Valle, M. Frances] Univ Maryland, Sch Nursing, Dept Org Syst & Adult Hlth, College Pk, MD USA.
   [Wilson, Lisa M.] Johns Hopkins Univ Bloomberg, Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA.
   [Lazarus, Gerald] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21218 USA.
   [Robinson, Karen A.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; University System of
   Maryland; University of Maryland College Park; Johns Hopkins University;
   Johns Hopkins Bloomberg School of Public Health; Johns Hopkins
   University; Johns Hopkins University
RP Robinson, KA (通讯作者)，1830 E Monument St,Suite 8068, Baltimore, MD USA.
EM krobin@jhmi.edu
RI ; Robinson, Karen/OWA-0447-2025
OI Rhee, Susan/0009-0002-3350-2245; 
FU PHS HHS [HHS 290-201-20007-I] Funding Source: Medline
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NR 43
TC 8
Z9 11
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2015
VL 23
IS 4
BP 506
EP 517
DI 10.1111/wrr.12295
PG 12
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CQ7EG
UT WOS:000360765100174
PM 25845268
DA 2026-07-24
ER
PT J
AU Stanirowski, PJ
   Wnuk, A
   Cendrowski, K
   Sawicki, W
AF Stanirowski, Pawe Jan
   Wnuk, Anna
   Cendrowski, Krzysztof
   Sawicki, Wodzimierz
TI Growth factors, silver dressings and negative pressure wound therapy in
   the management of hard-to-heal postoperative wounds in obstetrics and
   gynecology: a review
SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS
LA English
DT Review
DE Gynecology; Growth factor; Obstetrics; Negative pressure wound therapy;
   Platelet-rich plasma; Silver dressing; Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTION; PLATELET-RICH PLASMA;
   RISK-FACTORS; CESAREAN-SECTION; ABDOMINAL HYSTERECTOMY; NECROTIZING
   FASCIITIS; CARCINOMA; COMPLICATIONS; DEHISCENCE
AB The last two decades witnessed the development of numerous innovative regimens for the management of patients with abnormally healing and infected wounds. Growth factors, negative pressure wound therapy (NPWT) and antiseptic dressings containing silver are examples of methods with best documented efficacy, being widely used in the treatment of acute and chronic post-traumatic wounds, burns and ulcers of various etiology. As far as obstetrics and gynecology are concerned, prevention and treatment of infected, hard-to-heal postoperative wounds is of crucial importance. This article reviews the available literature to discuss the possibilities for use, efficacy and cost-effectiveness of growth factors, NPWT and silver dressings in the treatment of difficult-to-heal postsurgical wounds in obstetrics and gynecology.
   An extensive search of the English and Polish literature via PubMed and EMBASE databases was undertaken for articles published between January 1960 and April 30, 2014 to identify articles that described and assessed use, efficacy and cost-effectiveness of growth factors, silver dressings and NPWT in patients with hard-to-heal postoperative wounds following obstetric or gynecological surgery.
   Literature review regarding the use of growth factors, NPWT and silver dressings suggests that these methods may play an important role in the management of wounds after invasive obstetric and gynecological procedures. Obese patients, patients after vulvectomy or prior radiation therapy may benefit most, however, due to non-numerous randomized reports, prospective studies on the use of above-mentioned methods in the treatment of postsurgical wounds following obstetric and gynecological interventions are required.
C1 [Stanirowski, Pawe Jan; Wnuk, Anna; Cendrowski, Krzysztof; Sawicki, Wodzimierz] Med Univ Warsaw, Mazovian Brodno Hosp, Fac Med 2, Dept Obstet Gynecol & Oncol, Warsaw, Poland.
   [Stanirowski, Pawe Jan; Wnuk, Anna; Cendrowski, Krzysztof; Sawicki, Wodzimierz] Mazovian Brodno Hosp, PL-03242 Warsaw, Poland.
C3 Medical University of Warsaw
RP Stanirowski, PJ (通讯作者)，Med Univ Warsaw, Mazovian Brodno Hosp, Fac Med 2, Dept Obstet Gynecol & Oncol, Warsaw, Poland.
EM stanirowski@gmail.com
RI Stanirowski, Paweł Jan/H-5741-2019
OI Stanirowski, Paweł Jan/0000-0001-7445-7546; Sawicki,
   Włodzimierz/0000-0003-0812-7877; Wnuk, Anna/0000-0002-9731-0667;
   Cendrowski, Krzysztof/0000-0001-6283-3145
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NR 80
TC 23
Z9 28
U1 0
U2 43
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0932-0067
EI 1432-0711
J9 ARCH GYNECOL OBSTET
JI Arch. Gynecol. Obstet.
PD OCT
PY 2015
VL 292
IS 4
BP 757
EP 775
DI 10.1007/s00404-015-3709-y
PG 19
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CQ8EU
UT WOS:000360840100011
PM 25864095
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Li, TT
   Wang, GQ
   Yin, P
   Li, ZR
   Zhang, LC
   Liu, JH
   Li, M
   Zhang, LH
   Han, L
   Tang, PF
AF Li, Tongtong
   Wang, Guoqi
   Yin, Peng
   Li, Zhirui
   Zhang, Licheng
   Liu, Jianheng
   Li, Ming
   Zhang, Lihai
   Han, Li
   Tang, Peifu
TI Effect of negative pressure on growth, secretion and biofilm formation
   of Staphylococcus aureus
SO ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR
   MICROBIOLOGY
LA English
DT Article
DE Negative pressure; Staphylococcus aureus; Virulence; Biofilm formation
ID VACUUM-ASSISTED CLOSURE; MESENCHYMAL STEM-CELLS; VITRO WOUND MODEL;
   IN-VITRO; SUBINHIBITORY CONCENTRATIONS; VIRULENCE DETERMINANTS; MAGGOT
   EXCRETIONS; BACTERIAL-GROWTH; ALPHA-HEMOLYSIN; IMMUNE-SYSTEM
AB Negative pressure wound therapy (NPWT) has gained popularity in the management of contaminated wounds as an effective physical therapy, although its influence on the bacteria in the wounds remains unclear. In this study, we attempted to explore the effect of negative pressure conditions on Staphylococcus aureus, the most frequently isolated pathogen during wound infection. S. aureus was cultured in Luria-Bertani medium at subatmospheric pressure of -125 mmHg for 24 h, with the bacteria grown at ambient pressure as the control. The application of negative pressure was found to slow down the growth rate and inhibit biofilm development of S. aureus, which was confirmed by static biofilm assays. Furthermore, decreases in the total amount of virulence factors and biofilm components were observed, including alpha-hemolysin, extracellular adherence protein, polysaccharide intercellular adhesin and extracellular DNA. With quantitative RT-PCR analysis, we also revealed a significant inhibition in the transcription of virulence and regulatory genes related to wound infections and bacterial biofilms. Together, these findings indicated that negative pressure could inhibit the growth, virulence and biofilm formation of S. aureus. A topical subatmospheric pressure condition, such as NPWT, may be a potential antivirulence and antibiofilm strategy in the field of wound care.
C1 [Li, Tongtong; Yin, Peng] Nankai Univ, Coll Med, Tianjin 300071, Peoples R China.
   [Li, Tongtong; Wang, Guoqi; Yin, Peng; Li, Zhirui; Zhang, Licheng; Liu, Jianheng; Li, Ming; Zhang, Lihai; Tang, Peifu] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China.
   [Han, Li] Chinese PLA Inst Dis Control & Prevent, Ctr Hosp Infect Control, Beijing 100071, Peoples R China.
C3 Nankai University; Chinese People's Liberation Army General Hospital
RP Zhang, LH (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China.
EM zhanglihai301@gmail.com; hanlicdc@163.com; pftang301@163.com
RI Li, Zhirui/OJT-0490-2025
OI Tang, Peifu/0000-0003-4279-1704
FU National Natural Science Foundation of China [81472112]
FX This research was supported by the National Natural Science Foundation
   of China (No. 81472112). The authors declare that they have no conflicts
   of interest.
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NR 49
TC 19
Z9 20
U1 0
U2 37
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0003-6072
EI 1572-9699
J9 ANTON LEEUW INT J G
JI Antonie Van Leeuwenhoek
PD OCT
PY 2015
VL 108
IS 4
BP 907
EP 917
DI 10.1007/s10482-015-0545-9
PG 11
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA CQ8NG
UT WOS:000360864000010
PM 26272011
DA 2026-07-24
ER
PT J
AU Laperuta, P
   Napolitano, F
   Vatrella, A
   Di Crescenzo, RM
   Cortese, A
   Di Crescenzo, V
AF Laperuta, Paolo
   Napolitano, Filomena
   Vatrella, Alessandro
   Di Crescenzo, Rosa Maria
   Cortese, Antonio
   Di Crescenzo, Vincenzo
TI Post-pneumonectomy broncho-pleural fistula successfully closed by
   open-window thoracostomy associated with VAC therapy
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Post-pneumonectomy broncho-pleural fistula; Open-window thoracostomy;
   Vacuum assisted closure therapy
ID NEEDLE-ASPIRATION-CYTOLOGY; LYMPH-NODE; HODGKIN-LYMPHOMA; EMPYEMA SPACE;
   CLOSURE; LESIONS; FLAPS
AB Broncho-pleural fistula (BPF), is a dramatic complication that may occur after lung resection. The treatment is challenging due to its high rate of morbidity and mortality. Herein, a case of BPF associated with empyema, occurred in an elderly patient who had undergone to left pneumonectomy for non-small cell lung cancer (NSCLC), is reported. After various treatments including chest drainage and endoscopic procedures, BPF was successfully closed by open-window thoracotomy associated with vacuum assisted closure (V.A.C.) device therapy. The authors conclude that V.A.C. is a convenient and safe measure in the management of empyema with BPF. Moreover, in similar clinical contexts, V.A.C. may be the only option available that may assure the survival of the patient and the avoiding any later-phases of residual cavity. (C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [Laperuta, Paolo; Napolitano, Filomena; Vatrella, Alessandro; Di Crescenzo, Rosa Maria; Cortese, Antonio; Di Crescenzo, Vincenzo] Univ Salerno, Dept Med & Surg, Unit Maxillofacial Surg, I-84100 Salerno, Italy.
C3 University of Salerno
RP Di Crescenzo, V (通讯作者)，Univ Salerno, Dept Med & Surg, Thorac Surg, I-84131 Salerno, Italy.
EM laper@libero.it; milena.napolitano@yahoo.it; avatrella@unisa.it;
   vdcres@alice.it; ancortese@unisa.it; vdicrescenzo@unisa.it
RI Vatrella, Alessandro/K-8001-2016; cortese, antonio/K-7317-2016; di
   crescenzo, rosa maria/HKW-6011-2023
OI Vatrella, Alessandro/0000-0001-8265-3037; cortese,
   antonio/0000-0002-0875-0725; di crescenzo, rosa
   maria/0000-0003-0404-0141; Di Crescenzo, Vincenzo/0000-0001-8745-8089
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NR 24
TC 11
Z9 14
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD OCT
PY 2014
VL 12
SU 2
BP S17
EP S19
DI 10.1016/j.ijsu.2014.08.390
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CR0ER
UT WOS:000360991700005
PM 25159544
DA 2026-07-24
ER
PT J
AU Pellino, G
   Sciaudone, G
   Candilio, G
   De Fatico, GS
   Landino, I
   Della Corte, A
   Guerniero, R
   Benevento, R
   Santoriello, A
   Campitiello, F
   Selvaggi, F
   Canonico, S
AF Pellino, Gianluca
   Sciaudone, Guido
   Candilio, Giuseppe
   De Fatico, G. Serena
   Landino, Isabella
   Della Corte, Angela
   Guerniero, Raffaella
   Benevento, Raffaella
   Santoriello, Antonio
   Campitiello, Ferdinando
   Selvaggi, Francesco
   Canonico, Silvestro
TI Preventive NPWT over closed incisions in general surgery: Does age
   matter?
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Colorectal surgery; Breast; Surgical
   site infection; Surgical site event; SSI; Complication
ID SURGICAL SITE INFECTION; POUCH-ANAL ANASTOMOSIS; ULCERATIVE-COLITIS;
   CROHNS-DISEASE; RESTORATIVE PROCTOCOLECTOMY; ILEAL POUCH; STAPLED
   HAEMORRHOIDOPEXY; ANTIBIOTIC-PROPHYLAXIS; COLORECTAL SURGERY;
   RANDOMIZED-TRIAL
AB Surgical site events (SSE), including surgical wound complications and surgical site infections, are a major concern in patients undergoing general surgery operations. These increase the costs of care, and can lead to prolonged hospital stay and need for further treatments, ultimately resulting in poor quality of life. Negative pressure wound therapy (NPWT) has been recently reported as a preventive strategy to avoid SSE, but little is known on the topic, and particularly in geriatric population.
   Our primary aim was to assess the efficacy of NPWT by means of a pocket device (PICO, Smith & Nephew, London, UK) in preventing SSE compared with conventional dressings in patients undergoing surgery with primary wound closure for breast and for colorectal diseases in our Unit. Our secondary aims were to assess the efficacy and safety of PICO in elderly patients, and to seek for differences between breast and abdominal results.
   All consecutive patients undergoing breast and colorectal surgery in our Unit between September 2012 and May 2014 were prospectively enrolled in this open label controlled study. Breast patients receiving NPWT were assigned to group B1, those receiving conventional dressings were assigned to group B2. Colorectal patients were assigned to group C1 (NPWT) and C2 (conventional dressings) in similar fashion. Each group included 25 patients, and at least 10 (40%) patients aged over 65 years to allow sub-analyses.
   NPWT significantly reduced SSE in both breast and colorectal patients compared with controls. No significant differences were observed according to age. Similar benefits were observed in breast and colorectal patients.
   Our results suggest that PICO is an effective tool to prevent SSE in patients undergoing general surgery, irrespective of age. Its use is recommended in frail, elderly patients at risk of SSE. (C) 2014 Published by Elsevier Ltd on behalf of Surgical Associates Ltd.
C1 [Pellino, Gianluca; Sciaudone, Guido; Candilio, Giuseppe; De Fatico, G. Serena; Landino, Isabella; Della Corte, Angela; Guerniero, Raffaella; Benevento, Raffaella; Santoriello, Antonio; Campitiello, Ferdinando; Selvaggi, Francesco; Canonico, Silvestro] Univ Naples 2, Dept Med Surg Neurol Metab & Ageing Sci, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Canonico, S (通讯作者)，Univ Naples 2, Dept Med Surg Neurol Metab & Ageing Sci, Piazza Miraglia 2, I-80138 Naples, Italy.
EM gipe1984@gmail.com; guido.sciaudone@unina2.it; g.candilio@alice.it;
   seredefa@gmail.com; isabella.landino@fastwebnet.it;
   angeladellacorte@live.it; raffaella.guerniero@libero.it;
   raffaella.benevento@gmail.com; antonio.santoriello@unina2.it;
   ferdinando.campitiello@unina2.it; fselvaggi@hotmail.com;
   silvestro.canonico@unina2.it
RI Selvaggi, Francesco/HSH-7500-2023; Pellino, Gianluca/B-8458-2015
OI Selvaggi, Francesco/0000-0002-3219-3797; Pellino,
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CR Accardo G, 2014, MINERVA CHIR S1, V69, P97
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   WILSON APR, 1986, LANCET, V1, P311
NR 54
TC 60
Z9 67
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD OCT
PY 2014
VL 12
SU 2
BP S64
EP S68
DI 10.1016/j.ijsu.2014.08.378
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CR0ER
UT WOS:000360991700017
PM 25159226
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Arai, M
   Kushimoto, S
   Kim, S
   Masuno, T
   Hagiwara, J
   Ishii, H
   Yokota, H
AF Arai, Masatoku
   Kushimoto, Shigeki
   Kim, Shiei
   Masuno, Tomohiko
   Hagiwara, Jun
   Ishii, Hiromoto
   Yokota, Hiroyuki
TI A novel technique for managing open abdomen with the combined use of
   mesh-mediated traction and the bilateral anterior rectus abdominis
   sheath turnover flap method: how to do it
SO SURGERY TODAY
LA English
DT Article
DE Bilateral anterior rectus abdominis sheath turnover flap method;
   Negative pressure wound therapy; Open abdomen
ID CLOSURE
AB Proper management of abdominal compartment syndrome and open abdomen is important for improving the survival of critically ill patients. However, in cases requiring a prolonged period of open abdomen, it is frequently difficult to perform definitive fascial closure due to lateralization of the abdominal musculature. We herein present a novel combined technique for managing open abdomen. A 74-year-old male with diffuse peritonitis was transferred to our department, after which a long period of open abdomen made it difficult to achieve fascial closure. Polypropylene mesh was sutured to the fascial edges to reduce the gap, which was then serially tightened under negative pressure wound therapy. However, since it was not possible to accomplish definitive fascial closure, abdominal closure was performed using the bilateral anterior rectus abdominis sheath turnover flap method after removing the mesh, without any complications. This combined technique may be an effective alternative in patients requiring open abdomen with subsequent difficulty in achieving definitive fascial closure.
C1 [Arai, Masatoku; Kim, Shiei; Masuno, Tomohiko; Hagiwara, Jun; Ishii, Hiromoto; Yokota, Hiroyuki] Nippon Med Sch, Dept Emergency & Crit Care Med, Bunkyo Ku, Tokyo 1138603, Japan.
   [Kushimoto, Shigeki] Tohoku Univ, Grad Sch Med, Div Emergency & Crit Care Med, Aoba Ku, Sendai, Miyagi 9808574, Japan.
C3 Nippon Medical School; Tohoku University
RP Arai, M (通讯作者)，Nippon Med Sch, Dept Emergency & Crit Care Med, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan.
EM amasatoku@nms.ac.jp
RI Kushimoto, Shigeki/AET-6785-2022
FU Grants-in-Aid for Scientific Research [25462836] Funding Source: KAKEN
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Breuing K, 2010, SURGERY, V148, P544, DOI 10.1016/j.surg.2010.01.008
   Cheatham ML, 2013, WORLD J SURG, V37, P2018, DOI 10.1007/s00268-013-2080-z
   Kirkpatrick AW, 2013, INTENS CARE MED, V39, P1190, DOI 10.1007/s00134-013-2906-z
   Kushimoto S, 2007, WORLD J SURG, V31, P2, DOI 10.1007/s00268-006-0282-3
   Miyamoto Y, 2015, SURG TODAY, V45, P121, DOI 10.1007/s00595-014-0936-y
   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   Regner JL, 2012, WORLD J SURG, V36, P497, DOI 10.1007/s00268-011-1203-7
NR 8
TC 4
Z9 6
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD OCT
PY 2015
VL 45
IS 10
BP 1335
EP 1339
DI 10.1007/s00595-015-1133-3
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CR1GM
UT WOS:000361072900020
PM 25708720
DA 2026-07-24
ER
PT J
AU Suarez-Grau, JM
   Jurado, JFG
   Menchero, JG
   Luque, JAB
AF Manuel Suarez-Grau, Juan
   Guadalajara Jurado, Juan Francisco
   Gomez Menchero, Julio
   Bellido Luque, Juan Antonio
TI Delayed primary closure in open abdomen with stoma using dynamic closure
   system
SO SPRINGERPLUS
LA English
DT Article
DE Open abdomen; Surgery; ABRA; VAC; Abdominal wall; Closure;
   Compartimental syndrome
ID WOUND CLOSURE
AB Background: The situation of abdominal sepsis secondary to colonic perforation sometimes forces treat the patient with multiple interventions in the open abdomen (OA) context. Correct management of OA is important to restore the patient's clinical situation and to avoid further complications of the abdominal wall. Delayed primary closure of the abdomen using a dynamic and progressive traction is a relatively new technique for treating the OA.
   Case presentation: We report the case of a 50 year old woman with history of malnutrition and chronic obstructive pulmonary disease, affects for an OA after several surgical interventions. Two previous interventions (right colectomy, ileostomy and laparotomy with Bogota bag) for disseminated peritonitis and abdominal compartment syndrome were performed. Six days after the Bogota bag the of the dynamic closure system ABRA (R) system was placed to delayed primary closure of the abdomen with excellent result results of the contingency of the abdominal wall.
   Discussion: The most common technique in the current management of OA is the placement of vacuum-assisted closure or the use of a mesh. These systems generally require several operations to restore the integrity of the abdominal wall. However, the dynamic closure of the abdominal wall makes it possible to restore it into the same process.
   Conclusions: ABRA system allows delayed primary closure of the abdominal wall in an OA by sepsis secondary to colonic perforation. The stoma was not a problem with this technique. The final closure of the abdomen was at 16 days after the ABRA placement. The abdominal wall has not alterations in the follow up after 3 years.
C1 [Manuel Suarez-Grau, Juan; Guadalajara Jurado, Juan Francisco; Gomez Menchero, Julio; Bellido Luque, Juan Antonio] Gen Hosp Riotinto, Minas De Riotinto, Huelva, Spain.
RP Suarez-Grau, JM (通讯作者)，Gen Hosp Riotinto, Minas De Riotinto, Huelva, Spain.
EM graugrau@gmail.com
RI Suarez Grau, Juan Manuel/AAU-8685-2021; /G-4670-2015
OI Suarez Grau, Juan Manuel/0000-0002-2937-7683; 
CR [Anonymous], 2000, ACTA CHIRURG AUSTRIA
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NR 12
TC 1
Z9 2
U1 0
U2 5
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-1801
J9 SPRINGERPLUS
JI SpringerPlus
PD SEP 17
PY 2015
VL 4
AR 519
DI 10.1186/s40064-015-1316-9
PG 4
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CR4KJ
UT WOS:000361300600021
PM 26405639
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Balsa, IM
   Culp, WTN
AF Balsa, Ingrid M.
   Culp, William T. N.
TI Wound Care
SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
LA English
DT Article
DE Wound management; Wound healing; Bandage; Dressing
ID SMALL-INTESTINAL SUBMUCOSA; THICKNESS SKIN WOUNDS; SUCTION DRAINS;
   THERAPY; INFECTIONS; DOGS; FIBROBLASTS; IRRIGATION
AB Wound care requires an understanding of normal wound healing, causes of delays of wound healing, and the management of wounds. Every wound must be treated as an individual with regard to cause, chronicity, location, and level of microbial contamination, as well as patient factors that affect wound healing. Knowledge of wound care products available and when negative pressure wound therapy and drain placement is appropriate can improve outcomes with wound healing. Inappropriate product use can cause delays in healing. As a wound healing progresses, management of a wound and the bandage material used must evolve.
C1 [Balsa, Ingrid M.; Culp, William T. N.] Univ Calif Davis, Dept Surg & Radiol Sci, Davis, CA 95616 USA.
C3 University of California System; University of California Davis
RP Culp, WTN (通讯作者)，Univ Calif Davis, Dept Surg & Radiol Sci, One Shields Dr, Davis, CA 95616 USA.
EM wculp@ucdavis.edu
OI Balsa, Ingrid/0000-0002-1824-5896; Culp, William/0000-0001-6132-156X
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NR 55
TC 53
Z9 64
U1 1
U2 78
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0195-5616
EI 1878-1306
J9 VET CLIN N AM-SMALL
JI Vet. Clin. N. Am.-Small Anim. Pract.
PD SEP
PY 2015
VL 45
IS 5
BP 1049
EP +
DI 10.1016/j.cvsm.2015.04.009
PG 19
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CR8EH
UT WOS:000361583400012
PM 26022525
DA 2026-07-24
ER
PT J
AU Dondossola, D
   Cavenago, M
   Piconi, S
   Antonelli, B
   Melada, E
   Lonati, C
   Gatti, S
   Rossi, G
AF Dondossola, D.
   Cavenago, M.
   Piconi, S.
   Antonelli, B.
   Melada, E.
   Lonati, C.
   Gatti, S.
   Rossi, G.
TI Negative Pressure Wound Treatment of Infections Caused By Extensively
   Drug-Resistant Gram-Negative Bacteria After Liver Transplantation: Two
   Case Reports
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article; Proceedings Paper
CT 38th National Congress of the Italian-Transplantation-Society
CY SEP 24-26, 2014
CL Siena, ITALY
SP Italian Transplantat Soc
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTIONS; FUNGAL-INFECTIONS;
   INSTILLATION; THERAPY; SUSCEPTIBILITY; COMPLICATIONS; RECIPIENTS; PERIOD
AB Although survival after liver transplantation (LT) has progressively improved over the last years, an increased prevalence of clinically relevant infections in LT patients is well documented. In particular, the spread of infections sustained by extensively drug-resistant bacteria (XDR) produced an increase in the incidence of wound infections. Implementation of treatments for these life-threatening events is mandatory. This study describes 2 LT patients in whom XDR wound infection was effectively treated using negative pressure wound treatment (NPWT) combined with targeted local and systemic antibiotic therapy. Over the last 3 years, 2 of 8 patients with XDR infection admitted to our unit developed wound infection caused by XDR Klebsiella pneumoniae (KP-XDR). Positive results of the abdominal fluid culture and of the wound swab for KP-XDR were followed by sepsis. In both cases wound debridement was required and deep fascial layer dehiscence was detected. Combination antibiotic therapy was administered for sepsis treatment and, after failure of conventional NPWT, a NPWT with local instillation (NPWTi; V.A.C.-Ulta/ Vera Flo-Instillation Therapy-KCI USA, Inc., San Antonio, TX, USA) of colistinrifampicin was applied. After NPWTi application a reduction in bacterial load and exudate was observed with reduction in inflammatory markers. A complete healing of wound was achieved and both patients are currently alive. Instillation and NPWT are widely discussed in the literature. Results of the present study indicate beneficial effects of NPWT combined with targeted local and systemic antibiotic therapy; in both cases a life-threatening complication was cured. We consider local instillation of selected antibiotics applied to NPWTi a valuable tool for deep wound infection sustained by XDR bacteria.
C1 [Dondossola, D.; Cavenago, M.; Antonelli, B.; Melada, E.; Lonati, C.; Gatti, S.; Rossi, G.] IRCCS Ca Granda Osped Maggiore Policlin Milano, Hepatobiliarypancreat Surg Unit, Milan, Italy.
   [Piconi, S.] Azienda Osped Luigi Sacco, Infect Dis Unit, Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan;
   Luigi Sacco Hospital
RP Dondossola, D (通讯作者)，IRCCS Ca Granda Osped Maggiore Policlin Milano, Hepatobiliarypancreat Surg Unit, Via F Sforza, Milan, Italy.
EM dondossola.daniele@gmail.com
RI Gatti, Stefano/M-1780-2015; Cavenago, Marco/N-4743-2018; lonati,
   caterina/ABI-1503-2020; Rossi, Giorgio/M-3445-2015; dondossola,
   daniele/A-7978-2016
OI Gatti, Stefano/0000-0003-2209-4338; lonati,
   caterina/0000-0001-7855-7851; Rossi, Giorgio/0000-0002-5588-1306;
   dondossola, daniele/0000-0002-4374-3184; Antonelli,
   Barbara/0000-0001-8435-1294
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 28
TC 8
Z9 9
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD SEP
PY 2015
VL 47
IS 7
BP 2145
EP 2149
DI 10.1016/j.transproceed.2014.11.078
PG 5
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Immunology; Surgery; Transplantation
GA CR8ZW
UT WOS:000361644000015
PM 26361664
DA 2026-07-24
ER
PT J
AU Gillespie, BM
   Rickard, CM
   Thalib, L
   Kang, E
   Finigan, T
   Homer, A
   Lonie, G
   Pitchford, D
   Chaboyer, W
AF Gillespie, Brigid M.
   Rickard, Claire M.
   Thalib, Lukman
   Kang, Evelyn
   Finigan, Tracey
   Homer, Allison
   Lonie, Gordon
   Pitchford, Don
   Chaboyer, Wendy
TI Use of Negative-Pressure Wound Dressings to Prevent Surgical Site
   Complications After Primary Hip Arthroplasty: A Pilot RCT
SO SURGICAL INNOVATION
LA English
DT Article
DE hip replacement; orthopedic; infection; vacuum dressing; feasibility;
   complications
ID THERAPY; INFECTION
AB Purpose. Negative-pressure wound therapy (NPWT) is increasingly used for primary surgical incisions despite the paucity of evidence. Study objectives were to assess the use of NPWT on surgical sites to prevent infections and other wound complications after elective primary hip arthroplasty and to consider feasibility of a larger trial. Methods. A nonmasked, randomized controlled pilot trial. Patients were recruited preoperatively from the preadmission clinic of an Australian hospital during 2013-2014. Computer-generated randomization was performed with allocation concealed until completion of surgery. The intervention group received NPWT (PICO) while the control group received the standard care hydrocolloid, reinforced with 2 absorbent dressings. Patients were followed for 6 weeks for postoperative complications (infection, length of stay, readmission) and skin complications (bruising, seroma, hematoma, dehiscence). Feasibility end points included numbers recruited, randomized, and followed up; fidelity; and costs. Results. Of 77 people approached, 76 were recruited, and 70 were randomized. Of 35 in the negative-pressure group, 2 received the standard dressing. Attrition at 6 weeks exceeded 10% in both groups. Dressing costs were lower in the control group ($3.01/d vs $38.40/d); SSI incidence was 2/35 in the NPWT and 3/35 in the control group (intention to treat: risk ratio [RR] = 0.67; 95% confidence interval [CI] = 0.12-3.7; P = .65). NPWT patients experienced more postoperative wound complications (RR = 1.6; 95% CI = 1.0-2.5; P = .04). Conclusion. A reduction of 3% in SSI incidence suggests that a definitive trial requires approximately 900 patients per group. Yet there is uncertainty around the benefit of NPWT after elective hip arthroplasty.
C1 [Gillespie, Brigid M.; Rickard, Claire M.; Kang, Evelyn; Chaboyer, Wendy] Griffith Univ, Gold Coast, Qld 4222, Australia.
   [Thalib, Lukman] Kuwait Univ, Safat, Kuwait.
   [Finigan, Tracey; Homer, Allison; Lonie, Gordon; Pitchford, Don] Gold Coast Univ Hosp, Southport, Qld, Australia.
C3 Griffith University; Kuwait University; Gold Coast University Hospital
RP Gillespie, BM (通讯作者)，Griffith Univ, NHMRC Res Ctr Clin Excellence Nursing Intervent N, Gold Coast, Qld 4222, Australia.
EM b.gillespie@griffith.edu.au
RI Gillespie, Brigid/E-7799-2012; Thalib, Lukman/HAI-7553-2022; Rickard,
   Claire/C-3440-2008; Chaboyer, Wendy/F-9588-2018
OI Gillespie, Brigid/0000-0003-3186-5691; Thalib,
   Lukman/0000-0002-1211-6495; Rickard, Claire/0000-0002-6341-7415;
   Chaboyer, Wendy/0000-0001-9528-7814; Kang, Evelyn/0000-0001-8253-1638
FU Queensland Government Department of Employment, Economic Development &
   Innovation Smart Futures Research Fellowship; Office for Medical &
   Health Research, Queensland Government; National Health & Medical
   Research Council Centre
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: BG
   gratefully acknowledges the financial support of The Queensland
   Government Department of Employment, Economic Development & Innovation
   Smart Futures Research Fellowship and the Office for Medical & Health
   Research, Queensland Government; BG, CR, EK and WC also acknowledge the
   support of National Health & Medical Research Council Centre for
   Research Excellence in Nursing Interventions for Hospitalised Patients
CR Andersson AE, 2010, AM J INFECT CONTROL, V38, P711, DOI 10.1016/j.ajic.2010.03.017
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   Viera AJ, 2005, FAM MED, V37, P360
NR 23
TC 62
Z9 66
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD OCT
PY 2015
VL 22
IS 5
BP 488
EP 495
DI 10.1177/1553350615573583
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CS0RE
UT WOS:000361769100007
PM 25733548
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Chen, PY
   Hsu, CC
   Yang, KC
   Wu, CC
   Wang, CL
AF Chen, Pei-Yu
   Hsu, Chih-Chin
   Yang, Kai-Chiang
   Wu, Chang-Chin
   Wang, Chung-Li
TI The effects of negative pressure treatment on the extracellular matrix
   gene expression and protein production of fibroblasts
SO PROCESS BIOCHEMISTRY
LA English
DT Article
DE Wound healing; Negative pressure wound therapy; Fibroblast;
   Extracellular matrix
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; ANGIOGENESIS; GROWTH;
   PROLIFERATION; MECHANISM; MIGRATION
AB Although negative pressure wound therapy (NPWT) has been suggested for the management of acute and chronic wounds, the underlying mechanism of NPWT on the cellular level is not fully understood. Using a primary fibroblast culture model with controlled negative pressure, the cellular responses to the negative pressure was investigated. The present results showed that cell proliferation of fibroblasts was not affected under negative pressure. The mRNA expressions of collagen type I, collagen type Ill, and fibronectin were down-regulated when cells treated with negative pressure for once only. However, those mRNA expressions were up-regulated when cells subjected to periodical negative pressure consecutively for 5 days. The protein production of TGF-beta 1 was enhanced, while the TIMP-1, decorin, and IL-6 were not influenced. The pro-MMP-9 was not stimulated when fibroblasts subjected to negative pressure. The regulations of extracellular matrix production in fibroblasts provides an insight into the cellular mechanisms of NPWT. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Chen, Pei-Yu; Wu, Chang-Chin; Wang, Chung-Li] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Orthoped Surg, Coll Med, Taipei 10002, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Keelung 20401, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Univ, Sch Tradit Chinese Med, Coll Med, Taoyuan 33302, Taiwan.
   [Yang, Kai-Chiang] Taipei Med Univ, Sch Dent Technol, Coll Oral Med, Taipei 11031, Taiwan.
   [Wu, Chang-Chin] En Chu Kong Hosp, Dept Orthoped, New Taipei City 237, Taiwan.
   [Wang, Chung-Li] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Orthoped Surg,Yun Lin Branch, Yunlin 64041, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital; Chang
   Gung Memorial Hospital; Chang Gung University; Taipei Medical
   University; En Chu Kong Hospital; National Taiwan University; National
   Taiwan University Hospital
RP Wang, CL (通讯作者)，Natl Taiwan Univ Hosp, Dept Orthoped Surg, Yun Lin Branch, 579,Sec 2,Yunlin Rd, Touliu 640, Yunlin, Taiwan.
EM f92548050@gmail.com; steele1@ms10.hinet.net; pumpkin@tmu.edu.tw;
   dtorth65@yahoo.com.tw; chungli@ntu.edu.tw
RI Chen, Pei-yu/H-1669-2013; Yang, Kai-Chiang/AFN-1742-2022
OI Chen, Pei-yu/0000-0003-2793-2361; WANG, CHUNG-LI/0000-0002-3364-8183; 
FU National Science Council, Taiwan [NSC 98-2314-B-002-020-MY3]
FX The study was supported by grants from the National Science Council,
   Taiwan (NSC 98-2314-B-002-020-MY3).
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NR 42
TC 4
Z9 5
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-5113
EI 1873-3298
J9 PROCESS BIOCHEM
JI Process Biochem.
PD OCT
PY 2015
VL 50
IS 10
BP 1662
EP 1668
DI 10.1016/j.procbio.2015.06.014
PG 7
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Engineering
GA CS0TP
UT WOS:000361775400023
DA 2026-07-24
ER
PT J
AU Montori, G
   Di Giovanni, G
   Mzoughi, Z
   Angot, C
   Al Samman, S
   Solaini, L
   Cheynel, N
AF Montori, Giulia
   Di Giovanni, Giacomo
   Mzoughi, Zeineb
   Angot, Cedric
   Al Samman, Sophie
   Solaini, Leonardo
   Cheynel, Nicolas
TI Pneumoretroperitoneum and Pneumomediastinum Revealing a Left Colon
   Perforation
SO INTERNATIONAL SURGERY
LA English
DT Article
DE Pneumomediastinum; Retroperitoneum; Colonic; Perforation
ID SIGMOID DIVERTICULUM PERFORATION; SOFT-TISSUE INFECTIONS
AB Left colon perforation usually occurs in complicated diverticulitis or cancer. The most frequent signs are intraperitoneal abscess or peritonitis. In cases of retroperitoneal colonic perforation, diagnosis may be difficult. A 59-year-old woman presented with left thigh pain and with abdominal discomfort associated with mild dyspnea. Computed tomography scan showed air bubbles and purulent collection in the retroperitoneum, with subcutaneous emphysema extending from the left thigh to the neck. Computed tomography scan also revealed portal vein gas and thrombosis with multiple liver abscesses. An emergency laparotomy revealed a perforation of the proximal left colon. No masses were found. A left colectomy was performed. The retroperitoneum was drained and washed extensively. A negative pressure wound therapy was applied. A second-look laparotomy was performed 48 hours later. The retroperitoneum was drained and an end colostomy was performed. Intensive Care Unit postoperative stay was 9 days, and the patient was discharged on the 32nd postoperative day. Pneumoretroperitoneum and pneumomediastinum are rare signs of colonic retroperitoneal perforation. The diagnosis may be delayed, especially in the absence of peritoneal irritation. Clinical, laboratory, and especially radiologic parameters might be useful. Surgical treatment must be prompt to improve prognosis.
C1 [Montori, Giulia; Di Giovanni, Giacomo; Mzoughi, Zeineb; Angot, Cedric; Al Samman, Sophie; Cheynel, Nicolas] Ctr Hosp Univ Bocage, Dept Gen & Emergency Surg, Dijon, France.
   [Solaini, Leonardo] Univ Brescia, Dept Clin & Surg Sci, Surg Clin, I-25128 Brescia, Italy.
C3 Universite Bourgogne Europe; CHU Dijon Bourgogne; University of Brescia
RP Solaini, L (通讯作者)，Univ Brescia, Dept Clin & Surg Sci, Surg Clin, I-25128 Brescia, Italy.
EM leonardosolaini@gmail.com
RI ; Montori, Giulia/ABF-9661-2020; /AAQ-2317-2021
OI Solaini, Leonardo/0000-0002-5031-9285; Montori,
   Giulia/0000-0002-7649-2174; 
CR Biondo S, 2002, AM J SURG, V183, P256, DOI 10.1016/S0002-9610(02)00780-8
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   Yasar NF, 2011, ULUS TRAVMA ACIL CER, V17, P93, DOI 10.5505/tjtes.2011.69783
NR 10
TC 7
Z9 9
U1 0
U2 1
PU INT COLLEGE OF SURGEONS
PI CHICAGO
PA 1516 N LAKE SHORE DR, CHICAGO, IL 60610 USA
SN 0020-8868
J9 INT SURG
JI Int. Surg.
PD JUN
PY 2015
VL 100
IS 6
BP 984
EP 988
DI 10.9738/INTSURG-D-14-00201.1
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CS3OO
UT WOS:000361984200005
PM 26414818
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Karadsheh, MJ
   Nelson, J
   Wilcox, R
AF Karadsheh, Murad J.
   Nelson, Josh
   Wilcox, Richard
TI The Application of Skin Adhesive to Maintain Seal in Negative Pressure
   Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE tissue adhesive; negative pressure wound therapy; skin adhesives
ID VACUUM-ASSISTED CLOSURE; ALLERGIC CONTACT-DERMATITIS; BENZOIN
AB Background. Optimal wound healing in negative pressure wound therapy (NPWT) depends on a properly sealed vacuum system. Anatomically difficult wounds disrupt the adhesive dressing, resulting in air leaks that impair the integrity of this system. Several techniques have been used in previous reports to prevent air leaks, including the addition of skin adhesives (eg, Skin-Prep [Smith & Nephew, St. Petersburg, FL] or compound tincture of benzoin), hydrocolloid dressings, silicone, and stoma paste. The purpose of this case report is to demonstrate the effectiveness of using a cyanoacrylate tissue adhesive, dermaFLEX (FLEXCon, Spencer, MA), in maintaining an airtight, durable seal in NPWT. Materials and Methods. The authors present a patient with a difficult to manage anogenital wound where efforts to maintain an airtight seal in NPWT proved difficult. It was decided during the course of treatment to use the cyanoacrylate tissue adhesive to create an airtight, durable seal. The tissue adhesive was applied circumferentially to the skin surrounding the wound edge. After placement of vacuum-assisted closure foam over the wound, the adhesive dressing was applied with its edges overlapping the skin area where the tissue adhesive was applied. Results. The size of the wound was visibly reduced at each dressing change. An airtight seal was consistently maintained for 3 days at a time, surviving the difficult environment of the wound and maximizing the life of each adhesive dressing. Conclusion. For wounds in anatomically challenging locations, the use of the tissue adhesive appears to be a safe and viable option in creating a durable seal in NPWT.
C1 [Karadsheh, Murad J.] Michigan State Univ, Coll Human Med, Grand Rapids, MI 49503 USA.
   [Nelson, Josh] Grand Rapids Med Educ Partners, Grand Rapids, MI USA.
   [Wilcox, Richard] Spectrum Hlth Reg Burn Ctr, Grand Rapids, MI USA.
C3 Michigan State University; Michigan State University College of Human
   Medicine
RP Karadsheh, MJ (通讯作者)，Michigan State Univ, Coll Human Med, 15 Michigan St Ne, Grand Rapids, MI 49503 USA.
EM mkarads@gmail.com
RI /V-4883-2019
CR Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
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NR 17
TC 9
Z9 9
U1 0
U2 13
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2015
VL 27
IS 9
BP 244
EP 248
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CS4QY
UT WOS:000362062200003
PM 26367786
DA 2026-07-24
ER
PT J
AU Nolff, MC
   Layer, A
   Meyer-Lindenberg, A
AF Nolff, M. C.
   Layer, A.
   Meyer-Lindenberg, A.
TI Negative pressure wound therapy with instillation for body wall
   reconstruction using an artificial mesh in a Dachshund
SO AUSTRALIAN VETERINARY JOURNAL
LA English
DT Article
DE bite wounds; dogs; negative pressure wound therapy; polypropylene mesh
ID VACUUM-ASSISTED CLOSURE; THORACIC WALL; BITE WOUNDS; DOGS; MANAGEMENT;
   CATS
AB Case reportA 4-year-old spayed female Dachshund was presented in shock, displaying multiple haematomas and puncture wounds along the left abdominal wall and ventral aspect of the abdomen after being attacked by another dog. A defect of the left lateral body wall was palpated. Surgery revealed a massive body wall defect and concurrent injury of the intestines. Surgical debridement was performed and the injured portion of the jejunum was resected. The abdominal wall was reconstructed using a polypropylene mesh. Negative pressure wound therapy (NPWT) with instillation of 0.04% polyhexanide (-125mmHg, instillation interval of 2h, duration 20min) was started. Microbial culture after reconstruction of the defect and before application of the NPWTi dressing revealed multiresistant Staphylococcus pseudintermedius. The NPWT dressing was changed on days 2, 5 and 7. Microbial cultures obtained at the first two dressing changes were negative. Therapy was well tolerated and the mesh was completely covered by granulation tissue after 10days, when the wound was surgically closed.
   ConclusionBite wounds frequently result in massive, contaminated defects with impaired perfusion, and reconstruction using foreign material carries the risk of biofilm formation and infection. Instillation therapy may provide an alternative for bacterial clearance and fast integration of the mesh.
C1 [Nolff, M. C.; Layer, A.; Meyer-Lindenberg, A.] Univ Munich, Dept Clin Vet Med, Clin Small Anim Surg & Reprod, Munich, Germany.
C3 University of Munich
RP Nolff, MC (通讯作者)，Univ Munich, Dept Clin Vet Med, Clin Small Anim Surg & Reprod, Munich, Germany.
EM m.nolff@lmu.de
RI Meyer-Lindenberg, Andrea/H-1076-2011; Nolff, Mirja/W-6756-2019
OI Meyer-Lindenberg, Andrea/0000-0001-6137-3773; Nolff,
   Mirja/0000-0001-9317-7769
CR [Anonymous], ANTISEPTICS SURG
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NR 31
TC 12
Z9 15
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0005-0423
EI 1751-0813
J9 AUST VET J
JI Aust. Vet. J.
PD OCT
PY 2015
VL 93
IS 10
BP 367
EP 372
DI 10.1111/avj.12368
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CS6CI
UT WOS:000362164400024
PM 26412118
DA 2026-07-24
ER
PT J
AU Günal, Ö
   Tuncel, U
   Turan, A
   Barut, S
   Kostakoglu, N
AF Gunal, Ozgur
   Tuncel, Umut
   Turan, Aydin
   Barut, Sener
   Kostakoglu, Naci
TI The Use of Vacuum-Assisted Closure and GranuFoam Silver® Dressing in the
   Management of Diabetic Foot Ulcer
SO SURGICAL INFECTIONS
LA English
DT Article
ID PRESSURE WOUND THERAPY; NEGATIVE-PRESSURE; ESCHERICHIA-COLI;
   NANOPARTICLES; EXPERIENCE; DIAGNOSIS; EFFICACY
AB Purpose: The aim of this retrospective study was to evaluate the efficacy of vacuum-assisted closure (VAC) and GranuFoam Silver((R)) dressing (KCI, San Antonio, TX) compared with conventional GranuFoam((R)) dressing in the management of diabetic foot ulcers. Patients and Methods: Twenty-one consecutive patients treated with conventional or silver-coated foam dressing were reviewed retrospectively. The wound duration was 6mo. Group 1 (n=10) received conventional foam dressing (GranuFoam) and group 2 (n=11) received silver-coated foam dressing (GranuFoam Silver). The wound surface area, duration of treatment, bacteriology, and recurrence were compared between the groups. The mean age of the patients was 61.7010.52y in group 1 and 67.2711.28y in group 2. Results: In group 1, the average surface area of the wounds was 45.30 +/- 46.96cm(2) and 18.40 +/- 23.48cm(2) in the pre-treatment and post-treatment periods, respectively. There was a statistically significant difference between two measurements (p=0.005). Average duration of the treatment was 25.50 +/- 27.13d in this group. In group 2, average surface area of the wounds in the pre-treatment and post-treatment periods were 41.55 +/- 36.03cm(2) and 7.64 +/- 3.91cm(2), respectively. There was a statistically significant difference between two measurements (p=0.003). Average duration of the treatment was 10.09 +/- 3.51d in this group. The patients treated with silver-impregnated polyurethane foam dressing had reduced recurrence (2 vs. 7 wounds, p=0.030) and increased number of the culture-negative cases at the end of the treatment. Conclusion: With the results of the study, it was concluded that VAC GranuFoam silver dressing can be superior to conventional GranuFoam dressing in reducing the recurrence rate of infected diabetic foot ulcers.
C1 [Gunal, Ozgur; Barut, Sener] Gaziosmanpasa Univ, Fac Med, Dept Infect Dis & Clin Microbiol, TR-60100 Tokat, Turkey.
   [Tuncel, Umut; Turan, Aydin; Kostakoglu, Naci] Gaziosmanpasa Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, TR-60100 Tokat, Turkey.
C3 Tokat Gaziosmanpasa University; Tokat Gaziosmanpasa University
RP Günal, Ö (通讯作者)，Gaziosmanpasa Univ, Fac Med, Dept Infect Dis & Clin Microbiol, TR-60100 Tokat, Turkey.
EM ozgurgop@yahoo.com
RI Turan, Aydın/V-6669-2017; Barut, Sener/AAI-2731-2021; Gunal,
   Ozgur/I-7882-2014; Tuncel, Umut/P-3185-2015
OI Turan, Aydın/0000-0002-1540-1443; Barut, Sener/0000-0003-2047-8573;
   Gunal, Ozgur/0000-0002-7744-4123; Tuncel, Umut/0000-0001-5029-2927
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Thomas JG, 2011, J WOUND CARE, V20, P124, DOI 10.12968/jowc.2011.20.3.124
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   Tuncel U, 2012, INT WOUND J, V5, P1742
NR 33
TC 20
Z9 27
U1 1
U2 28
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD OCT 1
PY 2015
VL 16
IS 5
BP 558
EP 565
DI 10.1089/sur.2014.093
PG 8
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA CS6VT
UT WOS:000362221800014
PM 26114333
DA 2026-07-24
ER
PT J
AU Ciloglu, S
   Duran, A
   Pekcan, SY
   Buyukdogan, H
AF Ciloglu, Sinem
   Duran, Alpay
   Pekcan, Sirin Yasar
   Buyukdogan, Hasan
TI Leg ulcer in a patient with Rothmund-Thomson syndrome
SO SPRINGERPLUS
LA English
DT Article
ID THERAPY
AB Background: Rothmund-Thomson syndrome is a rare genetic condition exhibiting some dermatological, craniofacial, ophthalmological, and central nervous system abnormalities.
   Case description: A 51-year-old male patient, diagnosed with Rothmund-Thomson syndrome, attended to our outpatient clinic with complaint of unhealing wound in lower part of his left leg. Over this period, he had received various local therapies such as creams, wound dressings and hyperbaric oxygen therapy but no progress could be achieved. The wound gradually enlarged. Negative pressure wound therapy was applied at - 125 mmHg for 20 days. Wound was finally covered with split-thickness skin graft.
   Discussion and evaluation: There is only one case of Rothmund-Thomson syndrome with leg ulcer reported in the literature. However, complete closure has not been achieved with non-surgical therapies in this case. Therefore we performed negative pressure wound therapy followed by skin grafting.
   Conclusions: It is useful to treat therapy resistant wounds in Rothmund-Thomson syndrome by negative pressure, which can preserve residual vital tissue, and help clear away necrotizing tissue effectively and close the wound promptly.
C1 [Ciloglu, Sinem; Buyukdogan, Hasan] Haydarpasa Numune Training & Res Hosp, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkey.
   [Duran, Alpay] Sinop Ataturk State Hosp, Dept Plast Reconstruct & Aesthet Surg, Sinop, Turkey.
   [Pekcan, Sirin Yasar] Haydarpasa Numune Training & Res Hosp, Dept Dermatol, Istanbul, Turkey.
C3 Istanbul Haydarpasa Sultan Abdulhamid Training & Research Hospital;
   Istanbul Haydarpasa Numune Training & Research Hospital; Sinop
   University; Sinop Ataturk State Hospital; Istanbul Haydarpasa Numune
   Training & Research Hospital; Istanbul Haydarpasa Sultan Abdulhamid
   Training & Research Hospital
RP Duran, A (通讯作者)，Sinop Ataturk State Hosp, Dept Plast Reconstruct & Aesthet Surg, Sinop, Turkey.
EM dr.alpayduran@hotmail.com
RI ; Eroglu, Sinem/AAY-7996-2021; DURAN, ALPAY/IZP-7041-2023
OI Buyukdogan, Hasan/0000-0002-8508-1414; DURAN, ALPAY/0000-0003-0489-2088
CR Altunay I, 2010, INT WOUND J, V7, P531, DOI 10.1111/j.1742-481X.2010.00734.x
   Larizza L, 2010, ORPHANET J RARE DIS, V5, DOI 10.1186/1750-1172-5-2
   Seidel D, 2014, TRIALS, V15, DOI 10.1186/1745-6215-15-334
   Wang LL, 2001, AM J MED GENET, V102, P11, DOI 10.1002/1096-8628(20010722)102:1<11::AID-AJMG1413>3.0.CO;2-A
   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 5
TC 3
Z9 3
U1 0
U2 5
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-1801
J9 SPRINGERPLUS
JI SpringerPlus
PD OCT 5
PY 2015
VL 4
AR 572
DI 10.1186/s40064-015-1374-z
PG 3
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CS7AA
UT WOS:000362234700003
PM 26543707
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Szabó, L
   Szegedi, I
   Kiss, C
   Szikszay, E
   Remenyik, É
   Csízy, I
   Juhász, I
AF Szabo, Levente
   Szegedi, Istvan
   Kiss, Csongor
   Szikszay, Edit
   Remenyik, Eva
   Csizy, Istvan
   Juhasz, Istvan
TI Excessive pediatric fasciitis necrotisans due to Pseudomonas
   aeruginosa infection successfully treated with negative pressure
   wound therapy
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE fasciitis necrotisans; histiocytosis X; life-saving; negative pressure
   wound therapy; pediatric case; Pseudomonas aeruginosa infection
ID EXTENSIVE NECROTIZING FASCIITIS; VACUUM-ASSISTED CLOSURE; SOFT-TISSUE
   INFECTIONS; LEUKEMIA; CHILD
AB The case of a 10-year old female child is described with a history of myeloproliferative disorder having skin, bone and visceral involvement. Bone marrow biopsy revealed histiocytosis X. During chemotherapy necrotizing fasciitis of the lower abdominal wall was diagnosed. Multiple microbiological cultures taken from the wound base revealed Pseudomonas aeruginosa infection. Surgical necrectomy and application of negative pressure wound therapy (NPWT) was started together with intensive care treatment for sepsis. As both wound and general condition of the patient improved, autologous split thickness skin grafting was carried out in two sitting under continuing NPWT application. The applied skin grafts showed excellent take, the perilesional subcutaneous recesses resolved and complete healing was achieved after 28 days of NPWT treatment. Proper dermatological diagnosis and immediate escharectomy complemented with application of NPWT can be life-saving in the treatment of necrotizing fasciitis.
C1 [Szabo, Levente; Szegedi, Istvan; Kiss, Csongor; Szikszay, Edit; Csizy, Istvan] Univ Debrecen, Inst Pediat, Ctr Clin, H-4032 Debrecen, Hungary.
   [Remenyik, Eva; Juhasz, Istvan] Univ Debrecen, Dept Dermatol, Ctr Clin, Burn & Dermatosurg Unit, H-4032 Debrecen, Hungary.
   [Juhasz, Istvan] Univ Debrecen, Fac Med Dent, Dept Surg & Operat Tech, H-4032 Debrecen, Hungary.
C3 University of Debrecen; University of Debrecen; University of Debrecen
RP Juhász, I (通讯作者)，Univ Debrecen, Dept Dermatol, Ctr Clin, Nagyerdei Krt 98, H-4032 Debrecen, Hungary.
EM ijuhi@yahoo.com
CR Al-Subhi FS, 2010, CAN J PLAST SURG, V18, P139, DOI 10.1177/229255031001800412
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Endorf FW, 2009, J BURN CARE RES, V30, P769, DOI 10.1097/BCR.0b013e3181b48321
   Jaing TH, 2001, J PEDIATR SURG, V36, P948, DOI 10.1053/jpsu.2001.23998
   Lo WT, 2005, EUR J PEDIATR, V164, P113, DOI 10.1007/s00431-004-1554-2
   Melchionda F, 2011, PEDIATRIC REP, V3, P127, DOI 10.4081/pr.2011.e33
   Sarkar B, 2010, MINERVA CHIR, V65, P347
   Steinstraesser L, 2009, INT J LOW EXTR WOUND, V8, P28, DOI 10.1177/1534734609331991
NR 8
TC 10
Z9 11
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD SEP-OCT
PY 2015
VL 28
IS 5
BP 300
EP 302
DI 10.1111/dth.12252
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CS9YD
UT WOS:000362448900011
PM 26032296
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Kisch, T
   Liodaki, ME
   Mauss, KL
   Kalousis, K
   Wenzel, ET
   Mailaender, P
   Stang, FH
AF Kisch, Tobias
   Liodaki, Maria E.
   Mauss, Karl L.
   Kalousis, Konstantinos
   Wenzel, Eike T.
   Mailaender, Peter
   Stang, Felix H.
TI Reduced Amputation Rate by Circular TNP Application on Split-Skin Grafts
   After Deep Dermal Foot Scalds in Insulin-Dependent Diabetic Patients
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; LOWER-EXTREMITY; GLOBAL
   PREVALENCE; BURNS; MULTICENTER; STRESS; ULCERS
AB The incidence of insulin-dependent diabetes mellitus (IDDM) is expected to increase significantly. Due to peripheral neuropathy and angiopathy in IDDM patients, feet scalding results in deep burn injuries. Regularly amputations are needed with tremendous consequences. In relatively healthy patients, split-skin graft (SSG) take is better when topical negative pressure (TNP) is applied. We compared the outcome of circular TNP dressing with that of antiseptic dressing on freshly laid SSG after tangential excision in IDDM patients with deep dermal foot scalds. Seventy patients admitted to a burn center with isolated foot burns were identified (2008-2013). Ten of them suffered from IDDM and presented with a deep dermal foot scald. After tangential excision and split-skin grafting, five of them were treated with TNP. The others received an antiseptic dressing regime. Differences were analyzed using either Chi-square or Student's t-test. Group comparison regarding age, gender, body mass index, HbA1c on arrival, glucose in serum, IDDM disease duration, and TBSA revealed no significant differences. But percentage of graft take was at a significantly higher rate in the TNP group (90.2 +/- 4.017 vs 39 +/- 15.362) and fewer operations had to be performed compared to the control group (2.0 +/- 0.447 vs 4.6 +/- 0.927). Due to reduced occurrence of necrosis, the number of amputations required was significantly lower in the TNP group. TNP application on freshly laid SSG following tangential excision in IDDM patients after deep dermal foot scalds minimized amputation rates and therefore is of great benefit for such patients.
C1 [Kisch, Tobias; Liodaki, Maria E.; Mauss, Karl L.; Kalousis, Konstantinos; Wenzel, Eike T.; Mailaender, Peter; Stang, Felix H.] Univ Hosp Schleswig Holstein, Dept Plast Surg, Hand Surg, Burn Unit, D-23538 Lubeck, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital
RP Kisch, T (通讯作者)，Univ Hosp Schleswig Holstein, Dept Plast Surg, Hand Surg, Burn Unit, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.
RI Kalousis, Konstantinos/I-4398-2019; Kisch, Tobias/AAR-4695-2021
OI Kalousis, Konstantinos/0000-0002-3015-0806; Kisch,
   Tobias/0000-0002-0655-2119
CR Al-Qattan MM, 2000, BURNS, V26, P102, DOI 10.1016/S0305-4179(99)00097-2
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NR 24
TC 9
Z9 10
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD SEP-OCT
PY 2015
VL 36
IS 5
BP E253
EP E258
DI 10.1097/BCR.0000000000000184
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA CT0PM
UT WOS:000362498600001
PM 25412058
DA 2026-07-24
ER
PT J
AU Dini, V
   Oranges, T
   Rotella, L
   Romanelli, M
AF Dini, Valentina
   Oranges, Teresa
   Rotella, Luca
   Romanelli, Marco
TI Hidradenitis Suppurativa and Wound Management
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE hidradenitis suppurativa; acne inversa; wound care
ID VACUUM-ASSISTED CLOSURE; SURGICAL-TREATMENT; TREATMENT OPTION; CASE
   SERIES; EXCISION; LASER; CLINDAMYCIN; PREVALENCE; INFLIXIMAB; ADALIMUMAB
AB Hidradenitis suppurativa (HS) is a chronic, burdensome, debilitating disease of the hair follicle. It presents with recurrent painful inflamed and noninflamed lesions usually in specific body areas such as axillary, inguinal, perineal, and genital areas. It is associated with a large range of other diseases and conditions, such as obesity, arthropathy, inflammatory bowel diseases, and sqaumous cell carcinoma. Medical therapy may be systemic or topical, mainly based on antibiotics, retinoids, hormones and immunosuppressive drugs, including biological therapies. Surgical and laser therapies may be a valid therapeutic approach in order to treat locally recurring lesions. The aim of this article is to review the wound healing options after skin excision and laser treatments, with a focus on lesions left to heal by secondary intention, analyzing the efficacy of moist wound dressings, negative pressure wound therapy, bioactive dressings, such as platelet-rich plasma gel and hylarunoic acid scaffold, or autologous keratinocyte suspension in platelet concentrate and skin-grafting tecniques.
C1 [Dini, Valentina; Oranges, Teresa; Rotella, Luca; Romanelli, Marco] Univ Pisa, I-56126 Pisa, Italy.
C3 University of Pisa
RP Dini, V (通讯作者)，Univ Pisa, Dept Clin & Expt Med, Dermatol Unit, Via Roma 67, I-56126 Pisa, Italy.
EM valentina.dini@unipi.it
RI ; Oranges, Teresa/AAM-9690-2020; romanelli, marco/ABI-1154-2020; dini,
   valentina/F-7747-2017
OI Rotella, Luca/0000-0003-0141-6369; Oranges, Teresa/0000-0002-7277-3278;
   romanelli, marco/0000-0002-4127-0141; dini,
   valentina/0000-0002-8537-1999
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NR 75
TC 28
Z9 29
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2015
VL 14
IS 3
SI SI
BP 236
EP 244
DI 10.1177/1534734615598890
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CT3MN
UT WOS:000362710900006
PM 26248827
DA 2026-07-24
ER
PT J
AU Kakagia, D
AF Kakagia, Despoina
TI How to Close a Limb Fasciotomy Wound: An Overview of Current Techniques
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE limb fasciotomy wound; open trauma; dermatotraction; negative pressure
   therapy; compartment syndrome; assisted wound closure
ID DELAYED PRIMARY CLOSURE; VACUUM-ASSISTED CLOSURE; LOOP SHOELACE
   TECHNIQUE; VISCOELASTIC PROPERTIES; SKIN DEFECTS; DEVICE; TRAUMA;
   DERMATOTRACTION; STRETCH
AB Early fasciotomy is the gold standard of prevention and treatment of compartment syndrome; however, the resulting wounds may significantly increase morbidity. To address the challenge of timely and safe closure of fasciotomy wounds, numerous methods have been described. A thorough search of medical databases PubMed/MEDLINE, ScienceDirect, SCOPUS, EMBASE, and Google Scholar was conducted for articles published between 1976 and 2013 using the search terms limb fasciotomy wound closure, open wound management, skin stretching, and fasciotomy complications. A total of 49 articles on technique descriptions, case reports of 2 or more patients, and of complications and comparative studies regarding limb fasciotomy wound closure were included. Details of the duration of treatment, advantages and disadvantages, direct cost, and complications were data extracted for each technique from the 49 studies included in this overview. Thorough knowledge of available techniques and their comparative advantages is essential for their clinical implementation, careful selection of patients, management of possible complications, decreased morbidity, and hospital recovery time and is also crucial for optimization of functional and aesthetic outcomes.
C1 [Kakagia, Despoina] Democritus Univ Thrace, Alexandroupolis, Greece.
C3 Democritus University of Thrace
RP Kakagia, D (通讯作者)，7 P Kirillou St, Alexandroupolis 68100, Greece.
EM despoinakakagia@yahoo.com
RI Kakagia, Despoina/AAP-1202-2021
OI Kakagia, Despoina/0000-0003-2107-6170
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NR 57
TC 17
Z9 25
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2015
VL 14
IS 3
SI SI
BP 268
EP 276
DI 10.1177/1534734614550310
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CT3MN
UT WOS:000362710900010
PM 25256284
DA 2026-07-24
ER
PT J
AU Jang, MY
   Hong, JP
   Bordianu, A
   Suh, HS
AF Jang, Min Young
   Hong, Joon Pio
   Bordianu, Anca
   Suh, Hyun Suk
TI Using a Contradictory Approach to Treat a Wound Induced by Hematoma in a
   Patient With Antiphospholipid Antibody Syndrome Using Negative Pressure
   Wound Therapy: Lessons Learnt
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE negative pressure wound therapy (NPWT); wound; antiphospholipid antibody
   syndrome; hematoma; bleeding
ID MANAGEMENT; EFFICACY
AB A 48-year-old woman with antiphospholipid syndrome (APS) had multiple skin necrosis caused by massive bleeding and hematoma collection at the right lower leg, left thigh, and abdomen. During the first month, we did surgical debridement every 2 to 3 days with meticulous coagulation and applied negative pressure wound therapy (NPWT). Then as the base showed initial granulation, we changed the NPWT every 4 days. NPWT was used with lower pressure and cyclic mode (-40 to -75 mm Hg) to minimize trauma and to reduce the possibility of bleeding from the wounds. After 2 months of NPWT treatment, all the wounds eventually healed with secondary intension despite the patient's condition with diabetes, hemodialysis, anticoagulant use, and corticosteroid therapy. This report supports the idea that if accompanied by conservative debridement with meticulous bleeding control, application of NPWT in low pressures and close monitoring of the patient, NPWT is possible to use even in wounds of patients with risk for bleeding.
C1 [Jang, Min Young; Hong, Joon Pio; Suh, Hyun Suk] Univ Ulsan, Seoul Asan Med Ctr, Coll Med, Seoul, South Korea.
   [Bordianu, Anca] Carol Davila Univ Med & Pharm, Bucharest, Romania.
C3 University of Ulsan; Asan Medical Center; Carol Davila University of
   Medicine & Pharmacy
RP Suh, HS (通讯作者)，Asan Med Ctr, Dept Plast Surg, Poongnap2 Dong,388-1, Seoul 138736, South Korea.
EM hyunsuk.suh@amc.seoul.kr
RI SUH, Hyunsuk/ABE-9911-2020; Hong, Joon/AEV-0712-2022; /AAS-5572-2020
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   Kim EK, 2007, ANN PLAS SURG, V58, P536, DOI 10.1097/01.sap.0000245121.32831.47
   Lee KN, 2015, INT WOUND J, V12, P686, DOI 10.1111/iwj.12201
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NR 9
TC 8
Z9 10
U1 1
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2015
VL 14
IS 3
SI SI
BP 303
EP 306
DI 10.1177/1534734615598421
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CT3MN
UT WOS:000362710900016
PM 26248826
DA 2026-07-24
ER
PT J
AU Mihaljevic, AL
   Schirren, R
   Müller, TC
   Kehl, V
   Friess, H
   Kleeff, J
AF Mihaljevic, Andre L.
   Schirren, Rebekka
   Mueller, Tara C.
   Kehl, Victoria
   Friess, Helmut
   Kleeff, Joerg
TI Postoperative negative-pressure incision therapy following open
   colorectal surgery (Poniy): study protocol for a randomized controlled
   trial
SO TRIALS
LA English
DT Article
DE Abdominal dressing; Colorectal surgery; Negative-pressure wound therapy;
   Randomized trial; Surgical site infection; Wound edge protector; Wound
   infection
ID SURGICAL-SITE INFECTIONS; WOUND EDGE PROTECTION; MANAGEMENT-SYSTEM;
   HOSPITAL STAY; PROPHYLAXIS; MULTICENTER; PREVENTION; CEFOTETAN;
   CLASSIFICATION; COMPLICATIONS
AB Background: Postoperative surgical site infections cause substantial morbidity, prolonged hospitalization, costs and even mortality, and remain one of the most frequent surgical complications. In prospective trials with adequate follow-up, more than 20 % of patients undergoing elective colorectal surgery are affected and methods to reduce surgical site infections are urgently needed. Negative-pressure incision therapy is a novel intervention that holds promise to reduce postoperative wound infection rates, but has not yet been rigorously tested in a randomized controlled trial.
   Methods/Design: The aim is to investigate whether the postoperative application of a negative-pressure incision therapy device for 5-7 days reduces the rate of surgical site infections following open elective colorectal surgery by 50 %. This is a randomized, controlled, observer-blinded multicentre clinical trial with two parallel study groups. The primary outcome measure will be the rate of surgical site infections within 30 days postoperatively. Surgical site infections are defined according to criteria of the US Centers for Disease Control and Prevention. Statistical analysis of the primary endpoint measure will be based on the intention-to-treat population. The global level of significance is set at 5 % (two-sided) and the sample size (n = 170 per group) is determined to assure a power of 80 %.
   Discussion: The Poniy trial will explore whether the rate of surgical site infections can be reduced by the application of a negative-pressure incision therapy device in patients undergoing open elective colorectal surgery. Its pragmatic design guarantees high external validity and clinical relevance.
C1 [Mihaljevic, Andre L.; Schirren, Rebekka; Mueller, Tara C.; Friess, Helmut; Kleeff, Joerg] Tech Univ Munich, Klinikum Rechts Isar, Dept Surg, D-81675 Munich, Germany.
   [Mihaljevic, Andre L.; Schirren, Rebekka; Mueller, Tara C.; Friess, Helmut; Kleeff, Joerg] CHIR Net Munich, D-81675 Munich, Germany.
   [Kehl, Victoria] Tech Univ Munich, Klinikum Rechts Isar, Inst Med Stat & Epidemiol, D-81675 Munich, Germany.
   [Kleeff, Joerg] Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Gen Visceral & Pediat Surg, D-40225 Dusseldorf, Germany.
C3 Technical University of Munich; Technical University of Munich; Heinrich
   Heine University Dusseldorf; Heinrich Heine University Dusseldorf
   Hospital
RP Kleeff, J (通讯作者)，Royal Liverpool & Broadgreen Univ Hosp NHS Trust, Prescot St, Liverpool L7 8XP, Merseyside, England.
EM kleeff@tum.de
RI Friess, Helmut/ABO-1348-2022; Mueller, Tara/AAE-6774-2022; Kleeff,
   Jorg/B-2124-2009
OI Mihaljevic, André/0000-0003-1902-657X; Kleeff, Jorg/0000-0003-3432-6669
FU KCI Inc. (San Antonio, TX, USA)
FX The NPIT devices in the intervention group (Prevena Incision Management
   System) are provided by KCI Inc., Wiesbaden, Germany. Furthermore,
   financial support to cover costs for data management, monitoring and
   trial coordination are provided by KCI Inc. (San Antonio, TX, USA).
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   World Medical Association, 2013, 64 WMA GEN ASS
NR 44
TC 18
Z9 21
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD OCT 19
PY 2015
VL 16
AR 471
DI 10.1186/s13063-015-0995-4
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CT7QU
UT WOS:000363010400002
PM 26482031
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Maillard, H
AF Maillard, H.
TI Negative pressure therapy: NPT
SO ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
LA French
DT Article
DE Negative topic pressure; Surgical wound; Chronic wound; Budding
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; ULCERS
AB Negative pressure therapy or treatment (NPT) is used very frequently in hospitals in both surgical and medical departments. NPT consists of maintaining the wound surface at a pressure below ambient atmospheric pressure by means of a specially designed dressing attached to a depressurisation device as well as a system to drain exudate. NPT has been shown to be beneficial in increasing blood flow, thanks to feedback resulting from the decreased oxygen pressure, angiogenesis and reduction of the wound surface area. The French Health Authority (HAS) has issued recommendations for good use in a specific and limited series of applications. NPT may be used in post-traumatic or post-surgical wounds, burns, and in chronic wounds, such as bedsores and ulcers. It is also effective as an adjuvant treatment for infected wounds. In recent years, various different NPT devices have become commercially available. (C) 2015 Elsevier Masson SAS. All rights reserved.
C1 Ctr Hosp Gen, Serv Dermatol, F-72037 Le Mans 9, France.
RP Maillard, H (通讯作者)，Ctr Hosp Gen, Serv Dermatol, 194 Ave Rubillard, F-72037 Le Mans 9, France.
EM hmaillard@ch-lemans.fr
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NR 12
TC 1
Z9 2
U1 0
U2 4
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0151-9638
EI 2214-5451
J9 ANN DERMATOL VENER
JI Ann. Dermatol. Venereol.
PD AUG-SEP
PY 2015
VL 142
IS 8-9
BP 498
EP 501
DI 10.1016/j.annder.2015.06.008
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CT8VS
UT WOS:000363095600006
PM 26249531
DA 2026-07-24
ER
PT J
AU Achten, J
   Parsons, NR
   Bruce, J
   Petrou, S
   Tutton, E
   Willett, K
   Lamb, SE
   Costa, ML
AF Achten, Juul
   Parsons, Nick R.
   Bruce, Julie
   Petrou, Stavros
   Tutton, Elizabeth
   Willett, Keith
   Lamb, Sarah E.
   Costa, Matthew L.
TI Protocol for a randomised controlled trial of standard wound management
   versus negative pressure wound therapy in the treatment of adult
   patients with an open fracture of the lower limb: UK Wound management of
   Open Lower Limb Fractures (UK WOLFF)
SO BMJ OPEN
LA English
DT Article
ID ASSISTED CLOSURE THERAPY; HEALTH; INFECTION; EUROQOL; COSTS
AB Introduction: Patients who sustain open lower limb fractures have reported infection risks as high as 27%. The type of dressing applied after initial debridement could potentially affect this risk. In this trial, standard dressings will be compared with a new emerging treatment, negative pressure wound therapy, for patients with open lower limb fractures.
   Methods and analysis: All adult patients presenting with an open lower limb fracture, with a Gustilo and Anderson (G&A) grade 2/3, will be considered for inclusion. 460 consented patients will provide 90% power to detect a difference of eight points in the Disability Rating Index (DRI) score at 12 months, at the 5% level. A randomisation sequence, stratified by trial centre and G&A grade, will be produced and administered by a secure web-based service. A qualitative substudy will assess patients' experience of giving consent for the trial, and acceptability of trial procedures to patients and staff. Patients will have clinical follow-up in a fracture clinic up to a minimum of 12 months as per standard National Health Service (NHS) practice. Functional and quality of life outcome data will be collected using the DRI, SF12 and EQ-5D questionnaires at 3, 6, 9 and 12 months postoperatively. In addition, information will be requested with regards to resource use and any late complications or surgical interventions related to their injury. The main analysis will investigate differences in the DRI score at 1 year after injury, between the two treatment groups on an intention-to-treat basis. Tests will be two sided and considered to provide evidence for a significant difference if p values are less than 0.05.
   Ethics and dissemination: Ethical approval was given by NRES Committee West Midlands-Coventry & Warwickshire on 6/2/2012 (ref: 12/WM/0001). The results of the trial will be disseminated via peer-reviewed publications and presentations at relevant conferences.
C1 [Achten, Juul; Parsons, Nick R.; Bruce, Julie; Petrou, Stavros; Costa, Matthew L.] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England.
   [Tutton, Elizabeth; Willett, Keith; Lamb, Sarah E.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
C3 University of Warwick; University of Oxford
RP Achten, J (通讯作者)，Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England.
EM Juul.Achten@ndorms.ox.ac.uk
RI Petrou, Stavros/ABD-8323-2021; Achten, Juul/KUD-8515-2024; Parsons,
   Nick/AAA-8713-2019; Bruce, Julie/G-7588-2014
OI Petrou, Stavros/0000-0003-3121-6050; Achten, Juul/0000-0002-8857-5743;
   Parsons, Nick/0000-0001-9975-888X; Bruce, Julie/0000-0002-8462-7999;
   Lamb, Sarah/0000-0003-4349-7195; Costa, Matthew/0000-0003-3644-1388;
   Tutton, Elizabeth/0000-0003-3973-360X
FU Health Technology Assessment Programme of the National Institute of
   Health Research (NIHR) [HTA10/57/20]; NIHR Oxford Musculoskeletal
   Biomedical Research Unit; University of Warwick; University Hospitals
   Coventry and Warwickshire NHS trust; MRC [G0700452, G0501681] Funding
   Source: UKRI; Economic and Social Research Council [1499410] Funding
   Source: researchfish; Medical Research Council [G0700452, G0501681]
   Funding Source: researchfish; National Institute for Health Research
   [10/57/20] Funding Source: researchfish
FX This trial is funded through the Health Technology Assessment Programme
   of the National Institute of Health Research (NIHR; HTA10/57/20). The
   research was supported by the NIHR Oxford Musculoskeletal Biomedical
   Research Unit. The views expressed are those of the author(s) and not
   necessarily those of the NHS, the NIHR or the Department of Health. This
   protocol was written following the SPIRIT protocol guidance. The trial
   was co-sponsored by the University of Warwick and University Hospitals
   Coventry and Warwickshire NHS trust.
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NR 26
TC 17
Z9 22
U1 0
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2015
VL 5
IS 9
AR e009087
DI 10.1136/bmjopen-2015-009087
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CU4FZ
UT WOS:000363484000087
PM 26395498
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Alavi, A
   Kirsner, RS
AF Alavi, Afsaneh
   Kirsner, Robert S.
TI Local wound care and topical management of hidradenitis suppurativa
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE clindamycin; hidradenitis suppurativa; NPWT; resorcinol; retinoid;
   topical treatments
ID NEGATIVE-PRESSURE DRESSINGS; VACUUM-ASSISTED CLOSURE; THICKNESS
   SKIN-GRAFTS; CLINDAMYCIN
AB Hidradenitis suppurativa (HS) is a chronic, recurrent, debilitating disease predominantly involving apocrine gland-bearing skin. The folliculoinfundibular dysfunction and an aberrant cutaneous immune response to commensal bacteria are recognized as potential contributors. Topical antibiotics, such as clindamycin, and keratolytic agents have been used in the management of early stages of HS. Proper wound care is a key part of management, particularly in patients with advanced HS. The evidence for the optimal topical therapy or optimal local wound care is limited. As such, a multidisciplinary approach is necessary to address all aspects of HS, including topical therapy, systemic therapy, and proper wound care. The focus of this paper is to review the evidence for the topical management and local wound care strategies in patients with HS.
C1 [Alavi, Afsaneh] Univ Toronto, Dept Med Dermatol, Toronto, ON M5S 1B2, Canada.
   [Kirsner, Robert S.] Univ Miami, Dept Dermatol, Coral Gables, FL 33124 USA.
   [Kirsner, Robert S.] Univ Miami, Dept Cutaneous Surg, Coral Gables, FL 33124 USA.
C3 University of Toronto; University of Miami; University of Miami
RP Alavi, A (通讯作者)，Univ Toronto, Womens Coll Hosp, Wound Care Ctr, Dept Med Dermatol, Main Bldg,76 Grenville St,10th Fl, Toronto, ON M5S 1B2, Canada.
EM afsaneh.alavi@utoronto.ca
OI alavi, afsaneh/0000-0003-1171-4917
FU AbbVie
FX Dr Alavi is an advisor, consultant, and speaker for AbbVie and Janssen.
   She is an investigator for AbbVie and Novartis and received an
   unrestricted educational grant from AbbVie. Dr Kirsner declared no
   conflicts of interest.
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NR 18
TC 31
Z9 38
U1 1
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD NOV
PY 2015
VL 73
IS 5
SU 1
BP S55
EP S61
DI 10.1016/j.jaad.2015.07.048
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CU4IE
UT WOS:000363490300013
PM 26470618
DA 2026-07-24
ER
PT J
AU Malsiner, CCM
   Schmitz, M
   Horch, RE
   Keller, AK
   Leffler, M
AF Malsiner, Carmen C. M.
   Schmitz, Marweh
   Horch, Raymund E.
   Keller, Andrea K.
   Leffler, Mareike
TI Vessel transformation in chronic wounds under topical negative pressure
   therapy: an immunohistochemical analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Angiogenesis; Hypoxia; Topical negative pressure; Vacuum-assisted
   closure; Vessel proliferation
ID VACUUM-ASSISTED CLOSURE; ARTERIOVENOUS LOOP; TISSUE; HYPOXIA;
   ANGIOGENESIS; GROWTH; PROLIFERATION; EXPRESSION; VAC(R)
AB The underlying physiological mechanism of topical negative pressure (TNP) therapy is not yet completely understood. This prospective clinical study aims to clarify a potential influence of TNP therapy on vessel proliferation and hypoxia in chronic wounds. TNP was applied on chronic wounds of 16 patients (-125 mmHg) to prepare them for a plastic-surgical reconstruction using free or pedicled flaps. Tissue biopsies were taken from the wound edge and wound bed at different time points. All samples were stained with haematoxylin and eosin, hypoxia-induced factor-1 alpha and endothelial cell markers (CD31 and CD34) for the immunohistological analysis of inflammation, hypoxia and vessel proliferation. Between day 5 and day 8 of treatment, a considerable increase in blood vessel density could be observed, reaching a maximum of approximately 200% in contrast to the vessel density prior to treatment. In addition, the number of hypoxic and inflammatory cells was found to be increased at particular time points. This study demonstrates a stimulating effect on vessel proliferation under TNP treatment. TNP appears to support (neo-) angiogenesis and transformation of chronic non-healing wounds in a physiological wound healing process when combined with surgical debridement. This effect underlines the positive influence of TNP in the treatment of chronic wounds as shown by various clinical reports.
C1 [Malsiner, Carmen C. M.; Schmitz, Marweh; Horch, Raymund E.; Leffler, Mareike] Univ Erlangen Nurnberg, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
   [Keller, Andrea K.] Univ Erlangen Nurnberg, Dept Med Informat Biometry & Epidemiol, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@uk-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
CR [Anonymous], 2008, INT WOUND J S4, V5, piii, DOI DOI 10.1111/J.1742-1481X.2008.00537.X
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NR 51
TC 16
Z9 18
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2015
VL 12
IS 5
BP 501
EP 509
DI 10.1111/iwj.12143
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CU8RL
UT WOS:000363810700002
PM 24028468
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Mansoor, J
   Ellahi, I
   Junaid, Z
   Habib, A
   Ilyas, U
AF Mansoor, Junaid
   Ellahi, Irfan
   Junaid, Zartash
   Habib, Adeel
   Ilyas, Uzair
TI Clinical evaluation of improvised gauze-based negative pressure wound
   therapy in military wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chariker-Jeter system; Military wounds; Negative pressure wound therapy;
   VAC pack
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE
AB The use of negative pressure wound therapy (NPWT) in civilian and military wounds is found effective in promoting granulation tissue, decreasing exudate and improving patient comfort. The Use of gauze-based NPWT is increasing in civilian trauma cases with availability of proprietary systems using gauze as filler material rather than the traditionally used reticulated open-cell foam. Military trauma wounds differ from civilian trauma wounds in energy of impact, degree and nature of contamination as well as the hostile environments. The Use of gauze as filler material for NPWT in military trauma wounds is less well studied. This study is a retrospective analysis of use of improvised gauze-based NPWT in military trauma wounds. The whole assembly was constructed from commonly available operation theatre supplies and no proprietary system was used. Results were very encouraging and the use of this improvised method can be useful and cheap alternative to costly proprietary systems.
C1 [Mansoor, Junaid; Ellahi, Irfan; Junaid, Zartash; Habib, Adeel; Ilyas, Uzair] Combined Mil Hosp, Dept Surg, Peshawar, Pakistan.
RP Mansoor, J (通讯作者)，345-2 Shami Colony, Kharian Cantt, Punjab, India.
EM drjunaid2004@gmail.com
CR [Anonymous], 2008, BEST PRACT STAT GAUZ
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NR 24
TC 9
Z9 12
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2015
VL 12
IS 5
BP 559
EP 563
DI 10.1111/iwj.12164
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CU8RL
UT WOS:000363810700012
PM 24118754
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Karaca, S
   Kalangos, A
AF Karaca, Saziye
   Kalangos, Afksendiyos
TI Vacuum-assisted closure (VAC)-Instill® with continuous irrigation for
   the treatment of Mycoplasma hominis mediastinitis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cardiac surgery; Mycoplasma hominis; VAC-Instill (R)
ID INFECTION; PERICARDITIS
AB A 56-year-old patient who underwent ascending aorta replacement postoperatively developed mediastinitis with atypical Mycoplasma hominis. We present the first successful treatment of M. hominis mediastinitis after cardiac surgery with vacuum-assisted closure (VAC)-Instill (R) therapy combined with dilute antiseptic irrigation for bacterial eradication.
C1 [Karaca, Saziye; Kalangos, Afksendiyos] Univ Hosp Geneva, Dept Cardiovasc Surg, CH-1211 Geneva 14, Switzerland.
C3 University of Geneva
RP Karaca, S (通讯作者)，Univ Hosp Geneva, Dept Cardiovasc Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM saziye.karaca@hcuge.ch
RI Kalangos, Afksendiyos/AAM-8202-2021
CR AVRIL JL, 2000, BACTERIOLOGIE CLIN
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NR 8
TC 15
Z9 18
U1 0
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2015
VL 12
IS 5
BP 595
EP 597
DI 10.1111/iwj.12234
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CU8RL
UT WOS:000363810700019
PM 24684727
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Cemile, N
   Opara, P
   Ozturk, C
   Djohan, R
AF Ozturk, Cemile Nurdan
   Opara, Praise
   Ozturk, Can
   Djohan, Risal
TI Treatment of Foot Degloving Injury With Aid of Negative Pressure Wound
   Therapy and Dermal Regeneration Template
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE avulsion; fascia; lower extremity; skin; trauma; wound vacuum
ID VACUUM-ASSISTED CLOSURE; AVULSION INJURIES; SKIN-GRAFTS; RECONSTRUCTION;
   MANAGEMENT; INTEGRA; FLAP; SOLE; HEEL
AB Degloving injury of the foot continues to be a challenging condition to treat. Despite current advancements in reconstructive options, most of these injuries can result in amputations, causing physical and emotional impairment. Few reports have been published on the management of these complex traumatic injuries. Typical reconstruction options have included skin grafting and reattachment of the avulsed skin. Many treating physicians have encountered challenging issues in predicting tissue viability, knowing the extent of the injury, and making a logical decision for limb salvage procedures. The present report provides an algorithm of our approach in managing degloving injuries. A case of foot degloving injury, treated by serial surgical operations with the dominant aim of salvaging the avulsed tissue, is presented. The avulsed portion of the foot, with no identifiable vessels for microsurgical reattachment, was defatted and used as a full-thickness skin graft. Negative pressure wound therapy and a dermal regeneration template were used as adjunct techniques to help obtain good soft tissue coverage. The traditional treatment methods for degloving injuries and the applications of new wound care technologies are discussed. (C) 2015 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Ozturk, Cemile Nurdan; Ozturk, Can] Roswell Pk Canc Inst, Dept Head & Neck Surgery Plast & Reconstruct Surg, Buffalo, NY 14263 USA.
   [Djohan, Risal] Cleveland Clin, Inst Dermatol & Plast Surg, Dept Plast Surg, Cleveland, OH USA.
C3 Roswell Park Comprehensive Cancer Center; Cleveland Clinic Foundation
RP Cemile, N (通讯作者)，Roswell Pk Canc Inst, Dept Head & Neck Surgery Plast & Reconstruct Surg, Elm & Carlton St, Buffalo, NY 14263 USA.
EM cemile.ozturk@roswellpark.org
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NR 18
TC 8
Z9 11
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD NOV-DEC
PY 2015
VL 54
IS 6
BP 1132
EP 1135
DI 10.1053/j.jfas.2014.06.014
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA CU8WX
UT WOS:000363825900027
PM 26234924
DA 2026-07-24
ER
PT J
AU Lonie, S
   Hallam, J
   Yii, M
   Davis, P
   Newcomb, A
   Nixon, I
   Rosalion, A
   Ricketts, S
AF Lonie, Sarah
   Hallam, Jane
   Yii, Michael
   Davis, Philip
   Newcomb, Andrew
   Nixon, Ian
   Rosalion, Alexander
   Ricketts, Sophie
TI Changes in the management of deep sternal wound infections: a 12-year
   review
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE negative-pressure wound therapy; sternotomy; surgical wound infection;
   vacuum-assisted closure; wound closure technique
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   MUSCLE FLAPS; THERAPY; MODALITY; BRIDGE
AB BackgroundDeep sternal wound infection (DSWI) is a rare but life-threatening complication following cardiac surgery associated with increased morbidity and mortality. Management of these patients has evolved over the years and can include sternal rewiring, mediastinal irrigation, negative-pressure wound therapy (NPWT) dressing or repair with flaps. We reviewed changes in our management of DSWI and outcomes.
   MethodsUsing the Australian and New Zealand Society of Cardiac and Thoracic Surgeons database, 5472 underwent cardiac surgery at St Vincent's Hospital, Melbourne, and 42 were identified as developing DSWI requiring re-operation between June 2002 and September 2014. Data were collected pertaining to risk factors for DSWI, management strategies and outcomes. Patients were compared from a period prior to NPWT dressing use (June 2002-February 2006, n = 14) and since the NPWT has been used regularly in the management of DSWI (from March 2006, n = 28). Patients were also compared based on the requirement for flap closure of their sternal wound.
   ResultsBecause of the widespread use of NPWT dressings, there is a trend towards fewer sternal infections requiring flap closure (25 versus 42.8%) and less post-operative complications after definitive closure (7.1 versus 28.6%). Before and after widespread NPWT use, patients require similar number of re-operations before closure and have no significant differences in time to definitive closure or length of hospital stay.
   ConclusionThe use of NPWT dressings as a bridge to definitive closure may reduce the need for more burdensome flap reconstruction, does not delay definitive reconstruction or prolong hospital stay and may reduce post-reconstruction complications requiring re-operation.
C1 [Lonie, Sarah; Ricketts, Sophie] St Vincents Hosp, Dept Plast & Reconstruct Surg, Melbourne, Vic, Australia.
   [Lonie, Sarah; Hallam, Jane; Yii, Michael; Davis, Philip; Newcomb, Andrew; Nixon, Ian; Rosalion, Alexander] St Vincents Hosp, Dept Cardiothorac Surg, Melbourne, Vic, Australia.
C3 St Vincent's Health; St Vincent's Hospital Melbourne; NSW Health; St
   Vincents Hospital Sydney; NSW Health; St Vincents Hospital Sydney; St
   Vincent's Health; St Vincent's Hospital Melbourne
RP Lonie, S (通讯作者)，St Vincents Hosp, 41 Victoria Parade, Fitzroy, Vic 3065, Australia.
EM sjlonie88@gmail.com
RI Davis, Philip/A-9312-2011; Newcomb, Andrew/ABD-9220-2021; Lonie,
   Sarah/JXN-0672-2024
OI Newcomb, Andrew/0000-0002-0465-3602; Lonie, Sarah/0000-0001-8109-6507
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NR 25
TC 15
Z9 20
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD NOV
PY 2015
VL 85
IS 11
BP 878
EP 881
DI 10.1111/ans.13279
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CU9NY
UT WOS:000363872500020
PM 26331481
DA 2026-07-24
ER
PT J
AU Rodriguez-Unda, N
   Soares, KC
   Azoury, SC
   Baltodano, PA
   Hicks, CW
   Burce, KK
   Cornell, P
   Cooney, CM
   Eckhauser, FE
AF Rodriguez-Unda, Nelson
   Soares, Kevin C.
   Azoury, Said C.
   Baltodano, Pablo A.
   Hicks, Caitlin W.
   Burce, Karen K.
   Cornell, Peter
   Cooney, Carisa M.
   Eckhauser, Frederic E.
TI Negative-Pressure Wound Therapy in the Management of High-Grade Ventral
   Hernia Repairs
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article
DE Ventral hernia; Vacuum-assisted closure; Negative pressure wound
   therapy; Grade 3 hernia; abdominal wall reconstruction; Surgical site
   infection
ID ACELLULAR DERMAL MATRIX; ABDOMINAL-WALL DEFECTS; HIGH-RISK; INCISIONAL
   HERNIA; UMBILICAL HERNIA; SYNTHETIC MESH; POLYPROPYLENE MESH; OUTCOMES;
   RECONSTRUCTION; RECURRENCE
AB Despite improved operative techniques, open ventral hernia repair (VHR) surgery in high-risk, potentially contaminated patients remains challenging. As previously reported by our group, the use of a modified negative-pressure wound therapy system (hybrid-VAC or HVAC) in patients with grade 2 hernias is associated with lower surgical site occurrence (SSO) and surgical site infection (SSI) rates. Accordingly, the authors aim to evaluate whether the HVAC would similarly improve surgical site outcomes following VHR in patients with grade 3 hernias.
   A 4-year retrospective review (2011-2014) was conducted of all consecutive, modified ventral hernia working group (VHWG) grade 3 hernia repairs with HVAC closure performed by a single surgeon (FEE) at a single institution. Operative data and 90-day outcomes were evaluated. Overall outcomes (e.g., recurrence, reoperation, mortality) were reviewed for the study group.
   A total of 117 patients with an average age of 56.7 +/- 11.9 years were classified as grade 3 hernias and underwent open VHR with subsequent HVAC closure. Fifty patients were male (42.7 %), the mean BMI was 35.2 (+/- 9.5), and 60.7 % had a history of prior hernia repair. The average fascial defect size was 201.5 (+/- 167.3) cm(2) and the mean length of stay was 14.2 (+/- 9.3) days. Ninety-day outcomes showed an SSO rate of 20.7 % and an SSI rate of 5.2 %. The overall hernia recurrence rate was 4.2 % (n=6) with a mean follow-up of 11 +/- 7.3 months.
   Modified VHWG grade 3 ventral hernias are associated with significant morbidity. In our series utilizing the HVAC system after VHR, the observed rate of SSO and SSI compared favorably to reported series. Further prospective cost-effective studies are warranted to validate these findings.
C1 [Rodriguez-Unda, Nelson; Soares, Kevin C.; Azoury, Said C.; Baltodano, Pablo A.; Hicks, Caitlin W.; Burce, Karen K.; Cornell, Peter; Cooney, Carisa M.; Eckhauser, Frederic E.] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21287 USA.
C3 Johns Hopkins University
RP Eckhauser, FE (通讯作者)，Johns Hopkins Univ, Sch Med, Dept Surg, Blalock 618,600 N Wolfe St, Baltimore, MD 21287 USA.
EM feckhau2@jhmi.edu
RI Hicks, Caitlin/JAX-4080-2023; Soares, Kevin/PII-7807-2026
OI Hicks, Caitlin/0000-0001-7638-1936; 
FU KCI(R)
FX This study was made possible in part through an investigator initiated
   trial grant from KCI (R).
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NR 45
TC 13
Z9 13
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD NOV
PY 2015
VL 19
IS 11
BP 2054
EP 2061
DI 10.1007/s11605-015-2894-0
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA CV0YH
UT WOS:000363979300016
PM 26239514
DA 2026-07-24
ER
PT J
AU Murphy, P
   Lee, K
   Dubois, L
   DeRose, G
   Forbes, T
   Power, A
AF Murphy, Patrick
   Lee, Kevin
   Dubois, Luc
   DeRose, Guy
   Forbes, Thomas
   Power, Adam
TI Negative pressure wound therapy for high-risk wounds in lower extremity
   revascularization: study protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Surgical site infection; Vascular surgery; Negative pressure wound
   therapy; Prevena
ID SURGICAL SITE INFECTION
AB Background: Rates of surgical site infections (SSIs) following groin incision for femoral artery exposure are much higher than expected of a clean operation. The morbidity and mortality is high, particularly with the use of prosthetic grafts. The vascular surgery population is at an increased risk of SSIs related to peripheral vascular disease (PVD), diabetes, obesity, previous surgery and presence of tissue loss. Negative pressure wound therapy (NPWT) dressings have been used on primarily closed incisions to reduce surgical site infections in other surgical disciplines. We have not come across any randomized controlled trials to support the prophylactic use of negative pressure wound therapy in high-risk vascular patients undergoing lower limb revascularization.
   Methods/design: In this single-center, prospective randomized controlled trial, patients scheduled for a lower limb revascularization requiring open femoral artery exposure who are at a high risk (BMI > 30 kg/m(2), previous femoral cutdown or Rutherford V or VI category for chronic limb ischemia) will be eligible for the study. A total of 108 groin incisions will be randomized to the use of a negative pressure wound device or standard adhesive gauze dressing. Patients will be followed in hospital and reassessed within the first 30 days postoperatively. The primary outcome is SSI within the first 30 days of surgery and will be determined using the intention-to-treat principle. Secondary outcomes include length of stay, emergency room visits, reoperation, amputation and mortality. A cost analysis will be performed.
   Discussion: The trial is expected to define the role of NPWT in SSI prophylaxis for lower limb revascularization in high-risk vascular patients. The results of the study will be used to inform current best practice for perioperative care and the minimization of SSIs.
C1 [Murphy, Patrick] Univ Western Ontario, Dept Surg, Div Gen Surg, London, ON N6A 5A5, Canada.
   [Lee, Kevin; Dubois, Luc; DeRose, Guy; Power, Adam] Univ Western Ontario, Dept Surg, Div Vasc Surg, London, ON N6A 4G5, Canada.
   [Forbes, Thomas] Univ Toronto, Dept Surg, Div Vasc Surg, Toronto, ON M5T 1P5, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); University of Toronto
RP Power, A (通讯作者)，Univ Western Ontario, Dept Surg, Div Vasc Surg, 800 Commissioner Rd East, London, ON N6A 4G5, Canada.
EM adam.power@lhsc.on.ca
RI Murphy, Patrick/T-5337-2019
FU Western University (London, ON, Canada)
FX The study is funded by a university grant from the Western University
   (London, ON, Canada) and the NPWT devices are donated by Kinetic
   Concepts Inc. (San Antonio, TX, USA).
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
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NR 19
TC 13
Z9 13
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD NOV 4
PY 2015
VL 16
AR 504
DI 10.1186/s13063-015-1026-1
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CV1IN
UT WOS:000364007500003
PM 26537879
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kim, PJ
   Attinger, CE
   Oliver, N
   Garwood, C
   Evans, KK
   Steinberg, JS
   Lavery, LA
AF Kim, Paul J.
   Attinger, Christopher E.
   Oliver, Noah
   Garwood, Caitlin
   Evans, Karen K.
   Steinberg, John S.
   Lavery, Larry A.
TI Comparison of Outcomes for Normal Saline and an Antiseptic Solution for
   Negative-Pressure Wound Therapy with Instillation
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ANTIMICROBIAL SOLUTIONS; BACTERIAL COUNTS;
   POLYHEXANIDE; BETAINE; FOAM
AB Background: Negative-pressure wound therapy with instillation is an adjunctive treatment that uses periodic instillation of a solution and negative pressure for a wide diversity of wounds. A variety of solutions have been reported, with topical antiseptics as the most frequently chosen option. The objective of this study was to compare the outcomes of normal saline versus an antiseptic solution for negative-pressure wound therapy with instillation for the adjunctive treatment of infected wounds.
   Methods: This was a prospective, randomized, effectiveness study comparing 0.9% normal saline versus 0.1% polyhexanide plus 0.1% betaine for the adjunctive treatment of infected wounds that required hospital admission and operative debridement. One hundred twenty-three patients were eligible, with 100 patients randomized for the intention-to-treat analysis and 83 patients for the per-protocol analysis. The surrogate outcomes measured were number of operative visits, length of hospital stay, time to final surgical procedure, proportion of closed or covered wounds, and proportion of wounds that remained closed or covered at the 30-day follow-up.
   Results: There were no statistically significant differences in the demographic profiles in the two cohorts except for a larger proportion of male patients (p = 0.004). There was no statistically significant difference in the surrogate outcomes with the exception of the time to final surgical procedure favoring normal saline (p = 0.038).
   Conclusion: The authors' results suggest that 0.9% normal saline may be as effective as an antiseptic (0.1% polyhexanide plus 0.1% betaine) for negative-pressure wound therapy with instillation for the adjunctive inpatient management of infected wounds.
   CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
C1 [Kim, Paul J.] Medstar Georgetown Univ Hosp, Ctr Wound Healing & Hyperbar Med, Dept Plast Surg, Washington, DC 20007 USA.
   Univ Texas Southwestern, Dept Plast Surg, Dallas, TX USA.
C3 Georgetown University; University of Texas System; University of Texas
   Southwestern Medical Center
RP Kim, PJ (通讯作者)，Medstar Georgetown Univ Hosp, Ctr Wound Healing & Hyperbar Med, Dept Plast Surg, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM paul.j.kim@gunet.georgetown.edu
OI Lavery, Lawrence/0000-0002-7920-9952; , Paul/0000-0002-6186-6890; Evans,
   Karen/0000-0003-1056-2114
FU Acelity, Inc.
FX This study was not supported in any manner by Acelity, Inc., or B.
   Braun, Inc. Drs. Steinberg, Attinger, and Kim have all received research
   and consulting funding in the past from Acelity, Inc., the manufacturer
   of the device discussed in this article. The remaining authors have no
   financial information to disclose.
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NR 28
TC 82
Z9 96
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2015
VL 136
IS 5
BP 657E
EP 664E
DI 10.1097/PRS.0000000000001709
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CV2OS
UT WOS:000364096700001
PM 26505723
DA 2026-07-24
ER
PT J
AU Ozden, R
   Duman, IG
   Uruc, V
   Dogramaci, Y
   Kalaci, A
   Komurcu, E
AF Ozden, Raif
   Duman, Ibrahim Gokhan
   Uruc, Vedat
   Dogramaci, Yunus
   Kalaci, Aydiner
   Komurcu, Erkam
TI THE COMPARISON OF VACUUM ASSISTED CLOSURE AND CONVENTIONAL COTTON GAUZE
   DRESSING IN THE TREATMENT OF DEFECTIVE LOWER EXTREMITY INJURIES
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Vacuum assisted closure; Negative pressure wound therapy; Negative
   pressure wound therapy; Traumatic wounds
ID SOFT-TISSUE INJURIES; PROSPECTIVE RANDOMIZED-TRIAL; PRESSURE WOUND
   THERAPY; CLINICAL-EXPERIENCE; MANAGEMENT
AB We performed a retrospective analysis to compare the efficacy of the vacuum assisted closure (VAC) therapy and conventional cotton gauze dressing of wounds. From July 2011 to August 2013, 40 patients were included in the study. All patients were reconstructed with split thickness skin graft after the granulation tissue was sufficient Two groups of 20 patients Were compared retrospectively. Data were collected for gender, age, time needed for sufficient granulation tissue for split thickness skin grafts, length of stay in hospital and. number of debridement for wound VAC application, and conventional cotton gauze dressing methods. Demographic data were the Same. for two groups. Time needed to have a good granulation tissue that was sufficient for split thickness skin graft, length of stay in hospital, and number of debridement were significantly less in VAC treatment group (P<0,05). No major complication occurred that was directly attributable to treament. VAC therapy appears to be a good adjunct for the treatment of musculoskeletal injuries and found to facilitate the rapid formation of healthy granulation tissue on wounds in the lower limb and shortens the length of stay in hospital.
C1 [Ozden, Raif; Duman, Ibrahim Gokhan; Uruc, Vedat; Dogramaci, Yunus; Kalaci, Aydiner; Komurcu, Erkam] Mustafa Kemal Univ, Fac Med, Dept Orthopaed & Traumatol, Antakya, Hatay, Turkey.
C3 Hatay Mustafa Kemal University
RP Ozden, R (通讯作者)，Mustafa Kemal Univ, Fac Med, Dept Orthopaed & Traumatol, Antakya, Hatay, Turkey.
RI KALACI, AYDINER/AAB-5471-2022; /F-5634-2018; /ABE-3720-2020
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NR 33
TC 3
Z9 3
U1 0
U2 5
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2014
VL 30
IS 6
BP 1337
EP 1342
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CV2VI
UT WOS:000364114900028
DA 2026-07-24
ER
PT J
AU Perry, KL
   Rutherford, L
   Sajik, DMR
   Bruce, M
AF Perry, Karen L.
   Rutherford, Lynda
   Sajik, David M. R.
   Bruce, Mieghan
TI A preliminary study of the effect of closed incision management with
   negative pressure wound therapy over high-risk incisions
SO BMC VETERINARY RESEARCH
LA English
DT Article
DE Negative Pressure Wound Therapy; High-Energy Fracture; Arthrodesis;
   Swelling; Wound discharge
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; BLOOD-FLOW; SURGICAL
   INCISIONS; CALCANEAL FRACTURES; ORTHOPEDIC-SURGERY; INTERNAL-FIXATION;
   SKIN; CAT; DOGS
AB Background: Certain postoperative wounds are recognised to be associated with more complications than others and may be termed high-risk. Wound healing can be particularly challenging following high-energy trauma where wound necrosis and infection rates are high. Surgical incision for joint arthrodesis can also be considered high-risk as it requires extensive and invasive surgery and postoperative distal limb swelling and wound dehiscence are common. Recent human literature has investigated the use of negative pressure wound therapy (NPWT) over high-risk closed surgical incisions and beneficial effects have been noted including decreased drainage, decreased dehiscence and decreased infection rates. In a randomised, controlled study twenty cases undergoing distal limb high-energy fracture stabilisation or arthrodesis were randomised to NPWT or control groups. All cases had a modified Robert-Jones dressing applied for 72 h postoperatively and NPWT was applied for 24 h in the NPWT group. Morphometric assessment of limb circumference was performed at six sites preoperatively, 24 and 72 h postoperatively. Wound discharge was assessed at 24 and 72 h. Postoperative analgesia protocol was standardised and a Glasgow Composite Measure Pain Score (GCPS) carried out at 24, 48 and 72 h. Complications were noted and differences between groups were assessed.
   Results: Percentage change in limb circumference between preoperative and 24 and 72 h postoperative measurements was significantly less at all sites for the NPWT group with exception of the joint proximal to the surgical site and the centre of the operated bone at 72 h. Median discharge score was lower in the NPWT group than the control group at 24 h. No significant differences in GCPS or complication rates were noted.
   Conclusions: Digital swelling and wound discharge were reduced when NPWT was employed for closed incision management. Larger studies are required to evaluate whether this will result in reduced discomfort and complication rates postoperatively.
C1 [Perry, Karen L.] Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
   [Rutherford, Lynda; Sajik, David M. R.] Royal Vet Coll, Dept Clin Sci & Serv, Hatfield AL9 7TA, Herts, England.
   [Bruce, Mieghan] Royal Vet Coll, Dept Prod & Populat Hlth, Hatfield AL9 7TA, Herts, England.
C3 Michigan State University; University of London; University of London
   Royal Veterinary College; University of London; University of London
   Royal Veterinary College
RP Perry, KL (通讯作者)，Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, 736 Wilson Rd, E Lansing, MI 48824 USA.
EM kperry@cvm.msu.edu
RI Bruce, Mieghan/K-2472-2019; Perry, Karen/AAY-7641-2020
OI Bruce, Mieghan/0000-0003-3176-2094; Perry, Karen/0000-0001-6456-1817
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NR 58
TC 12
Z9 15
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1746-6148
J9 BMC VET RES
JI BMC Vet. Res.
PD NOV 9
PY 2015
VL 11
AR 279
DI 10.1186/s12917-015-0593-4
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CV6GW
UT WOS:000364369700002
PM 26552901
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rezzadeh, KS
   Nojan, M
   Buck, A
   Li, A
   Vardanian, A
   Crisera, C
   Festekjian, J
   Jarrahy, R
AF Rezzadeh, Kameron S.
   Nojan, Miriam
   Buck, Anisa
   Li, Andrew
   Vardanian, Andrew
   Crisera, Christopher
   Festekjian, Jaco
   Jarrahy, Reza
TI The use of negative pressure wound therapy in severe open lower
   extremity fractures: identifying the association between length of
   therapy and surgical outcomes
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Negative pressure wound therapy; Perioperative; Reconstructive surgery
ID OPEN TIBIAL FRACTURES; VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES;
   MANAGEMENT; RECONSTRUCTION; INFECTION; COVERAGE; TRAUMA
AB Background: Negative pressure wound therapy (NPWT) is a widely accepted method of temporary coverage for complex lower extremity wounds before definitive reconstruction. However, the precise role of NPWT in the perioperative management of patients with complicated lower extremity injuries remains unclear. In this study, we examine the effect of NPWT on flap complications and overall outcomes based on timing of soft-tissue reconstruction relative to initial injury and implementation of NPWT.
   Methods: We retrospectively reviewed the medical records of 32 consecutive patients presenting to a single institution receiving lower extremity reconstruction after Gustilo class IIIB or IIIC open tibial fractures over a 5-y period. Length of hospitalization, number of surgical procedures, flap failure, infection, and nonunion were parameters of interest in this study.
   Results: The incidence of complications in patients treated with NPWT was lower compared with patients who underwent wet-to-dry dressing changes, regardless of when surgery was performed. The highest rate of complications was observed in patients operated on >6 wk after injury and who received wet-to-dry dressing changes wound care. By comparison, those who underwent surgery within 1 wk of injury and who were bridged with NPWT had the lowest rate of complications.
   Conclusions: The use of NPWT therapy in the perioperative management of patients with open lower extremity fractures reduces complication rates associated with limb salvage surgery. Our results suggest that NPWT can be used as a temporizing measure to optimize patients before flap surgery, effectively lengthening the window of opportunity for definitive reconstruction. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Rezzadeh, Kameron S.; Nojan, Miriam; Buck, Anisa; Li, Andrew; Vardanian, Andrew; Crisera, Christopher; Festekjian, Jaco; Jarrahy, Reza] Univ Calif Los Angeles, David Geffen Sch Med, Div Plast & Reconstruct Surg, Dept Surg, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA
RP Jarrahy, R (通讯作者)，Univ Calif Los Angeles, David Geffen Sch Med, Div Plast & Reconstruct Surg, Dept Surg, 200 UCLA Med Plaza,Suite 465, Los Angeles, CA 90095 USA.
EM rjarrahy@mednet.ucla.edu
OI Vardanian, Andrew/0009-0004-9764-8029; Li, Anew/0000-0001-9933-7057
CR Arangio GA, 1997, J TRAUMA, V42, P942, DOI 10.1097/00005373-199705000-00027
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NR 23
TC 23
Z9 30
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD DEC
PY 2015
VL 199
IS 2
BP 726
EP 731
DI 10.1016/j.jss.2015.06.004
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CV7DW
UT WOS:000364433600061
PM 26141870
DA 2026-07-24
ER
PT J
AU Altintas, B
   Biber, R
   Brem, MH
AF Altintas, Burak
   Biber, Roland
   Brem, Matthias H.
TI The accelerating effect of negative pressure wound therapy with Prevena™
   on the healing of a closed wound with persistent serous secretion
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Closed wound; NPWT; Wound secretion
AB Negative pressure wound therapy has been lately used on closed incisions in the immediate postoperative period to accelerate wound healing. However, there are no data in the literature regarding the use of this type of therapy for wounds with persistent secretion in the early postoperative care. We present the first report of persistent postoperative serous wound secretion in a patient after femoral nailing treated successfully with Prevena (KCI), a closed incision negative pressure management system (CINPWT).
C1 [Altintas, Burak; Biber, Roland; Brem, Matthias H.] Klinikum Nurnberg, Dept Trauma & Orthoped Surg, Nurnberg, Germany.
C3 Klinikum Nurnberg
RP Brem, MH (通讯作者)，Klinikum Nurnberg, Dept Trauma & Orthoped Surg, Breslauerstr 201, Nurnberg, Germany.
EM Matthias.brem@klinikum-nuernberg.de
RI Biber, Roland/AAP-6691-2021
OI Biber, Roland/0000-0002-7700-0311
CR DeCarbo WT, 2010, J FOOT ANKLE SURG, V49, P299, DOI 10.1053/j.jfas.2010.01.002
   Kilpadi DV, 2011, WOUND REPAIR REGEN, V19, P588, DOI 10.1111/j.1524-475X.2011.00714.x
   Meeker J, 2011, J ORTHOP TRAUMA, V25, P756, DOI 10.1097/BOT.0b013e318211363a
   Pachowsky M, 2012, INT ORTHOP, V36, P719, DOI 10.1007/s00264-011-1321-8
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
NR 5
TC 12
Z9 13
U1 0
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2015
VL 12
IS 6
BP 662
EP 663
DI 10.1111/iwj.12198
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CW0VP
UT WOS:000364708200009
PM 24393137
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Lee, KN
   Ben-Nakhi, M
   Park, EJ
   Hong, JP
AF Lee, Kangwoo N.
   Ben-Nakhi, Muneera
   Park, Eun J.
   Hong, Joon P.
TI Cyclic negative pressure wound therapy: an alternative mode to
   intermittent system
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cyclic mode; Diabetic foot; Negative pressure wound therapy; Wound
ID VACUUM-ASSISTED CLOSURE; BLOOD-FLOW; DRESSINGS; FLAPS
AB The purpose of this study was to develop and test a novel mode of negative pressure wound therapy (NPWT) that minimises pain while preserving the efficacy in wound healing. A porcine model was used in this study. Wounds were generated in animals and treated with either simple dressing or various treatment modes of NPWT. The wound volume, perfusion level and vasculature status were analysed and compared among different groups. Clinical application was performed to evaluate the level of pain occurring when negative pressure is applied. Among the NPWT groups, the Cyclic-50 group showed most decrement in wound volume, even though statistical relevance was not found (P = 0302). The perfusion level was significantly increased in the Cyclic-50 group compared with the Intermittent group (P < 0001) and the Cyclic-100 group (P = 0004). Evaluation of blood vessel formation revealed that the Cyclic-50 group showed the highest number of vasculature with statistical significance (P < 0001). In clinical application, the cyclic group showed significant decrease in pain compared with the intermittent group (P = 0001). The cyclic NPWT mode decreased patient discomfort while maintaining superior wound healing effects as the intermittent mode.
C1 [Lee, Kangwoo N.; Ben-Nakhi, Muneera; Park, Eun J.; Hong, Joon P.] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Plast & Reconstruct Surg, Seoul 138736, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Hong, JP (通讯作者)，Univ Ulsan, Coll Med, Asan Med Ctr, Dept Plast & Reconstruct Surg, 388-1 Poongnap Dong, Seoul 138736, South Korea.
EM joonphong@amc.seoul.kr
RI Park, Eunju/AAC-5266-2021; Hong, Joon/AEV-0712-2022
CR Apostoli Alberto, 2008, Prof Inferm, V61, P158
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NR 29
TC 23
Z9 32
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2015
VL 12
IS 6
BP 686
EP 692
DI 10.1111/iwj.12201
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CW0VP
UT WOS:000364708200013
PM 24373578
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Scarci, M
   Abah, U
   Solli, P
   Page, A
   Waller, D
   van Schil, P
   Melfi, F
   Schmid, RA
   Athanassiadi, K
   Uva, MS
   Cardillo, G
AF Scarci, Marco
   Abah, Udo
   Solli, Piergiorgio
   Page, Aravinda
   Waller, David
   van Schil, Paul
   Melfi, Franca
   Schmid, Ralph A.
   Athanassiadi, Kalliopi
   Uva, Miguel Sousa
   Cardillo, Giuseppe
TI EACTS expert consensus statement for surgical management of pleural
   empyema
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Video-assisted thoracic surgery; Pleural infection; Empyema
ID ASSISTED THORACOSCOPIC SURGERY; COMPLICATED PARAPNEUMONIC EFFUSIONS;
   INTRAPLEURAL STREPTOKINASE; POSTPNEUMONECTOMY EMPYEMA; INTRATHORACIC
   APPLICATION; TUBE THORACOSTOMY; THORACIC-SURGERY; CONTROLLED-TRIAL;
   CHILDREN; DECORTICATION
AB Pleural infection is a frequent clinical condition. Prompt treatment has been shown to reduce hospital costs, morbidity and mortality. Recent advances in treatment have been variably implemented in clinical practice. This statement reviews the latest developments and concepts to improve clinical management and stimulate further research. The European Association for Cardio-Thoracic Surgery (EACTS) Thoracic Domain and the EACTS Pleural Diseases Working Group established a team of thoracic surgeons to produce a comprehensive review of available scientific evidence with the aim to cover all aspects of surgical practice related to its treatment, in particular focusing on: surgical treatment of empyema in adults; surgical treatment of empyema in children; and surgical treatment of post-pneumonectomy empyema (PPE). In the management of Stage 1 empyema, prompt pleural space chest tube drainage is required. In patients with Stage 2 or 3 empyema who are fit enough to undergo an operative procedure, there is a demonstrated benefit of surgical debridement or decortication [possibly by video-assisted thoracoscopic surgery (VATS)] over tube thoracostomy alone in terms of treatment success and reduction in hospital stay. In children, a primary operative approach is an effective management strategy, associated with a lower mortality rate and a reduction of tube thoracostomy duration, length of antibiotic therapy, reintervention rate and hospital stay. Intrapleural fibrinolytic therapy is a reasonable alternative to primary operative management. Uncomplicated PPE [without bronchopleural fistula (BPF)] can be effectively managed with minimally invasive techniques, including fenestration, pleural space irrigation and VATS debridement. PPE associated with BPF can be effectively managed with individualized open surgical techniques, including direct repair, myoplastic and thoracoplastic techniques. Intrathoracic vacuum-assisted closure may be considered as an adjunct to the standard treatment. The current literature cements the role of VATS in the management of pleural empyema, even if the choice of surgical approach relies on the individual surgeon's preference.
C1 [Scarci, Marco; Abah, Udo; Solli, Piergiorgio; Page, Aravinda] Papworth Hosp, Dept Cardiothorac Surg, Cambridge, Cambs, England.
   [Waller, David] Glenfield Hosp, Dept Thorac Surg, Leicester, Leics, England.
   [van Schil, Paul] Univ Antwerp Hosp, Dept Thorac & Vasc Surg, Antwerp, Belgium.
   [Melfi, Franca] Univ Pisana, Azienda Osped, Dept Cardiothorac Surg, Pisa, Italy.
   [Schmid, Ralph A.] Univ Hosp Bern, Div Gen Thorac Surg, CH-3010 Bern, Switzerland.
   [Athanassiadi, Kalliopi] Evangelismos Med Ctr, Unit Thorac Surg, Athens, Greece.
   [Uva, Miguel Sousa] Hosp Cruz Vermelha, Unit Cardiac Surg, Lisbon, Portugal.
   [Cardillo, Giuseppe] Carlo Forlanini Hosp, Az Osped S Camillo Forlanini, Unit Thorac Surg, Rome, Italy.
C3 Papworth Hospital; University Hospitals of Leicester NHS Trust;
   University of Leicester; Glenfield Hospital; University of Antwerp;
   University of Pisa; Azienda Ospedaliero Universitaria Pisana; University
   of Bern; University Hospital of Bern; Evangelismos Hospital; Azienda
   Ospedaliera San Camillo-Forlanini
RP Scarci, M (通讯作者)，Papworth Hosp NHS Fdn Trust, Cambridge CB23 3RE, England.
EM marco.scarci@nhs.net
RI Athanassiadi, Kalliopi/AAO-7787-2021; Van Schil, Paul/AAC-8139-2019;
   Castaldo, Giuseppe/AAC-6782-2022; Scarci, Marco/AAD-5166-2020; solli,
   piergiorgio/AAC-3340-2019; Sousa Uva, Miguel/AAR-9327-2020
OI Scarci, Marco/0000-0002-4459-7721; solli,
   piergiorgio/0000-0002-4890-2578; Schmid, Ralph
   Alexander/0000-0003-0699-079X; melfi, franca/0000-0002-1773-8269; Sousa
   Uva, Miguel/0000-0001-6353-653X
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NR 81
TC 147
Z9 166
U1 1
U2 13
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD NOV
PY 2015
VL 48
IS 5
BP 642
EP 653
DI 10.1093/ejcts/ezv272
PG 12
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA CW1PG
UT WOS:000364762900004
PM 26254467
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Wang, RR
   Feng, YH
   Di, B
AF Wang, Ruran
   Feng, Yanhua
   Di, Bo
TI Comparisons of negative pressure wound therapy and ultrasonic
   debridement for diabetic foot ulcers: a network meta-analysis
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Negative pressure wound therapy; ultrasound debridement; diabetic foot;
   network meta-analysis
ID VACUUM-ASSISTED CLOSURE; INTERVENTIONS; MULTICENTER; ENHANCE
AB Objective: a network meta-analysis was performed to compare the strength and weakness of negative pressure wound therapy (NPWT) with ultrasound debridement (UD) as for diabetic foot ulcers (DFU). Methods: PubMed, Ovid EMBASE, Web of Science, Cochrane library databases, and Chinese Biomedical Literature Database were searched till February 2015. Clinical compared studies of negative pressure wound therapy and ultrasound debridement were enrolled. The primary efficacy outcomes included healed ulcers, reduction of ulcer areas and time to closure. Secondary amputation including major and minor amputations was used to assess the safety profile. Results: Out of 715 studies, 32 were selected which enrolled 2880 diabetic patients. The pooled analysis revealed that NPWT including vacuum assisted closure (VAC) and vacuum sealing drainage (VSD) were as efficacious as ultrasound debridement improving healed ulcers, odds ratio, 0.86; 95% CI 0.28 to 2.6 and 1.2; 95% CI 0.38 to 4, respectively. However, both were better to standard wound care in wound healing patients. Compared with the standard wound care treated diabetic foot ulcers, NPWT and UD resulted in a significantly superior efficacy in time to wound closure and decrement in area of wound. No significances were observed between NPWT and UD groups in both indicators. Fewer patients tended to receive amputation in NPWT and UD groups compared to standard wound care group. Conclusions: The results of the network meta-analysis indicated that negative pressure wound therapy was similar to ultrasound debridement for diabetic foot ulcers, but better than standard wound care both in efficacy and safety profile.
C1 [Wang, Ruran] China Acad Chinese Med Sci, South Guanganmen Hosp, Dept Surg, Beijing 102600, Peoples R China.
   [Feng, Yanhua] China Acad Chinese Med Sci, South Guanganmen Hosp, Dept Rehabil, Beijing 102600, Peoples R China.
   [Di, Bo] China Acad Chinese Med Sci, Grad Sch, Beijing 102600, Peoples R China.
C3 China Academy of Chinese Medical Sciences; China Academy of Chinese
   Medical Sciences; China Academy of Chinese Medical Sciences
RP Feng, YH (通讯作者)，China Acad Chinese Med Sci, South Guanganmen Hosp, Dept Rehabil, 138 Xingfeng Rd, Beijing 102600, Peoples R China.
EM ruran777@sohu.com
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NR 45
TC 20
Z9 30
U1 0
U2 13
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 8
BP 12548
EP 12556
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CW8TJ
UT WOS:000365271900067
PM 26550165
DA 2026-07-24
ER
PT J
AU Li, WH
   Ji, L
   Tao, WD
AF Li, Weihua
   Ji, Lei
   Tao, Weidong
TI Effect of vacuum sealing drainage in osteofascial compartment syndrome
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Vacuum sealing drainage; osteofascial compartment syndrome; comparison
ID FREE-FLAP TRANSPLANTATION; PRESSURE; THERAPY; WOUNDS
AB Objectives: To investigate the effect of vacuum sealing drainage in the patients with osteofascial compartment syndrome in comparison to conventional treatment. Methods: Fifty-two patients diagnosed with osteofascial compartment syndrome were enrolled in this study. They were randomly divided into two groups based on treatments: vacuum sealing drainage and conventional treatment. After operation, the length of hospital stay and antibiotics administration were recorded in the two groups, as well as swelling elimination and wound closure. Results: No significant difference was observed in terms of the baseline characteristics between the two groups. There are no obvious local or systemic complications in all cases. In contrast to conventional treatment group, the time of swelling elimination, wound closure, hospital stay and antibiotics application were reduced significantly in vacuum sealing drainage group. No allergic reactions or other side effects were observed after the application of vacuum sealing drainage material, indicating its safety. Conclusion: Vacuum sealing drainage is effective in treating osteofascial compartment syndrome with better clinical outcomes than conventional therapy.
C1 [Li, Weihua; Ji, Lei; Tao, Weidong] Second Peoples Hosp Nantong, Natong 226002, Jiangsu, Peoples R China.
RP Tao, WD (通讯作者)，Second Peoples Hosp Nantong, Dept Orthoped Surg, 43 Xinglong St,Tangzha Town, Natong 226002, Jiangsu, Peoples R China.
EM papersub@sina.com
RI tao, weidong/HJZ-3254-2023
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   Scott JR, 1997, AM SURGEON, V63, P801
   Tang J, 2010, CHIN J TRAUMATOL, V13, P289, DOI 10.3760/cma.j.issn.1008-1275.2010.05.007
   Wang JN, 2011, J CRANIOFAC SURG, V22, P1100, DOI 10.1097/SCS.0b013e3182107731
   Yang YH, 2013, J PLAST RECONSTR AES, V66, pE209, DOI 10.1016/j.bjps.2013.03.006
NR 21
TC 15
Z9 16
U1 0
U2 8
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 9
BP 16112
EP 16116
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CW8TX
UT WOS:000365273300060
PM 26629121
DA 2026-07-24
ER
PT J
AU Frankel, JK
   Rezaee, RP
   Harvey, DJ
   McBeath, ER
   Zender, CA
   Lavertu, P
AF Frankel, Jonathan K.
   Rezaee, Rod P.
   Harvey, Donald J.
   McBeath, Evan R.
   Zender, Chad A.
   Lavertu, Pierre
TI Use of negative pressure wound therapy with instillation in the
   management of cervical necrotizing fasciitis
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Article
DE necrotizing fasciitis; cervical; instillation; wound vacuum therapy;
   negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; INFECTED WOUNDS
AB Background. Cervical necrotizing fasciitis is an aggressive infection that can be rapidly fatal if aggressive therapies are not initiated early. Negative pressure wound therapy has been established as an effective tool in promoting wound healing, but its use in the acutely infected wound has been avoided because it limits frequent irrigations and standard dressing changes.
   Methods. We discuss a novel application of negative pressure wound therapy with instillation in an immunocompromised patient with extensive cervical necrotizing fasciitis.
   Results. The negative pressure wound therapy with instillation provided pain relief by minimizing the frequency of dressing changes, increased the speed of healing, helped to control infection, and facilitated the development of a healthy wound bed sufficient for reconstruction with a split thickness skin graft.
   Conclusion. The role of negative pressure wound therapy with instillation continues to expand and can be used in the management of both acute and chronic wounds in the head and neck. (C) 2015 Wiley Periodicals, Inc.
C1 [Frankel, Jonathan K.; Rezaee, Rod P.; McBeath, Evan R.; Zender, Chad A.; Lavertu, Pierre] Univ Hosp Case Med Ctr, Otolaryngol Head & Neck Surg, Cleveland, OH 44106 USA.
   [Harvey, Donald J.] Univ Hosp Case Med Ctr, Plast Surg, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital; University System of Ohio; Case Western
   Reserve University; Case Western Reserve University Hospital
RP Rezaee, RP (通讯作者)，Univ Hosp Case Med Ctr, Ear Nose & Throat Inst, 11100 Euclid Ave,LKS 5045,Room 4517, Cleveland, OH 44106 USA.
EM Rod.Rezaee@UHHospitals.org
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   D'Hondt M, 2011, TECH COLOPROCTOL, V15, P75, DOI 10.1007/s10151-010-0662-4
   Gabriel A, 2012, INT WOUND J, V9, P25, DOI 10.1111/j.1742-481X.2012.01014.x
   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
   Jerome D, 2007, J WOUND OSTOMY CONT, V34, P191, DOI 10.1097/01.WON.0000264834.18732.3b
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   Malik V, 2010, EUR ARCH OTO-RHINO-L, V267, P1169, DOI 10.1007/s00405-010-1248-5
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   Wiedeck C, 2009, INFECTION, V37, P7
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NR 12
TC 21
Z9 25
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD NOV
PY 2015
VL 37
IS 11
BP E157
EP E160
DI 10.1002/hed.24028
PG 4
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA CX0SD
UT WOS:000365406100006
PM 25756193
DA 2026-07-24
ER
PT J
AU Kimura, M
   Nawata, K
   Kinoshita, O
   Hatano, M
   Imamura, T
   Kinugawa, K
   Ono, M
AF Kimura, Mitsutoshi
   Nawata, Kan
   Kinoshita, Osamu
   Hatano, Masaru
   Imamura, Teruhiko
   Kinugawa, Koichiro
   Ono, Minoru
TI Successful Treatment of Intractable Fluid Retention Using Tolvaptan
   After Treatment for Postoperative Mediastinitis in a Patient With a Left
   Ventricular Assist Device
SO INTERNATIONAL HEART JOURNAL
LA English
DT Article
DE Congestive symptom; Hyponatremia; Volume overload negative-pressure
   wound therapy
ID HEART-FAILURE; URINE OSMOLALITY; EXPERIENCE; TRANSPLANTATION;
   ANTAGONIST; SINGLE; BRIDGE; TRIAL
AB The use of implantable continuous-flow left ventricular assist devices (LVADs) as a bridge to transplant is effective for patients with congestive heart failure (I-IF). However, some patients develop congestive symptoms due to right-sided 11F even with LVAD support. Tolvaptan, a vasopressin type 2 receptor antagonist, corrects both congestion and hyponatremia in patients with advanced HE We report herein a case involving a patient who underwent LVAD implantation and developed hyponatremia and congestive symptoms after negative-pressure wound therapy and omental transposition for postoperative mediastinitis. Hemodynarnic evaluation performed after negative-pressure wound therapy revealed elevation of both right arterial pressure and pulmonary capillary wedge pressure, and suggested biventricular dysfunction despite LVAD support. Symptoms improved after starting administration of tolvaptan. Tolvaptan may be useful for correcting hyponatremia and volume overload in patients under LVAD support.
C1 [Kimura, Mitsutoshi; Nawata, Kan; Kinoshita, Osamu; Ono, Minoru] Univ Tokyo, Grad Sch Med, Dept Cardiac Surg, Tokyo 1138655, Japan.
   [Hatano, Masaru] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan.
   [Imamura, Teruhiko; Kinugawa, Koichiro] Univ Tokyo, Grad Sch Med, Dept Therapeut Strategy Heart Failure, Tokyo 1138655, Japan.
C3 University of Tokyo; University of Tokyo; University of Tokyo
RP Ono, M (通讯作者)，Univ Tokyo, Grad Sch Med, Dept Cardiac Surg, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM ono-tho@h.u-tokyo.ac.jp
RI ; Imamura, Teruhiko/AFD-8074-2022; Nawata, Kan/AAD-7153-2020
OI Kimura, Mitsutoshi/0009-0007-9071-4400; 
FU Otsuka Pharmaceutical (Tokyo); Grants-in-Aid for Scientific Research
   [15K09065] Funding Source: KAKEN
FX Dr. Teruhiko Imamura and Dr. Koichiro Kinugawa belong to the Department
   of Therapeutic Strategy for Heart Failure, which is an endowed
   department sponsored by 13 companies including Otsuka Pharmaceutical
   (Tokyo). Koichiro Kinugawa was a consultant for Otsuka Pharmaceutical
   and has received honoraria from Otsuka Pharmaceutical for lectures. The
   other authors have no conflicts of interest to declare.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Atkins BZ, 2011, AM J SURG, V202, P565, DOI 10.1016/j.amjsurg.2011.06.013
   De Brabandere K, 2012, TEX HEART I J, V39, P367
   Decaux G, 2008, LANCET, V371, P1624, DOI 10.1016/S0140-6736(08)60695-9
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   Imamura T, 2013, INT HEART J, V54, P115, DOI 10.1536/ihj.54.115
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   Kanaya M, AM J THER IN PRESS
   Kawata M, 2011, J ARTIF ORGANS, V14, P159, DOI 10.1007/s10047-011-0555-y
   Kimura M, 2015, J CARDIOL, V65, P383, DOI 10.1016/j.jjcc.2014.06.007
   Kimura M, 2014, ANN THORAC CARDIOVAS, V20, P842, DOI 10.5761/atcs.cr.12.02192
   Konstam MA, 2007, JAMA-J AM MED ASSOC, V297, P1319, DOI 10.1001/jama.297.12.1319
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NR 18
TC 6
Z9 6
U1 0
U2 2
PU INT HEART JOURNAL ASSOC
PI TOKYO
PA UNIV TOKYO, GRADUATE SCHOOL MEDICINE, DEPT CARDIOVASCULAR MEDICINE,
   HONGO 7-3-1, BUNKYO-KU, TOKYO, 113-8655, JAPAN
SN 1349-2365
EI 1349-3299
J9 INT HEART J
JI Int. Heart J.
PD SEP
PY 2015
VL 56
IS 5
BP 574
EP 577
DI 10.1536/ihj.14-412
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CX1LR
UT WOS:000365458200020
PM 26370363
OA Bronze
DA 2026-07-24
ER
PT J
AU Sajid, MT
   Mustafa, QU
   Shaheen, N
   Hussain, SM
   Shukr, I
   Ahmed, M
AF Sajid, Muhammad Tanveer
   Mustafa, Qurat Ul Ain
   Shaheen, Neelofar
   Hussain, Syed Mukarram
   Shukr, Irfan
   Ahmed, Muhammad
TI Comparison of Negative Pressure Wound Therapy Using Vacuum-Assisted
   Closure with Advanced Moist Wound Therapy in the Treatment of Diabetic
   Foot Ulcers
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Diabetes; Foot ulcer; Vaccum assisted closure; Advance moist wound
   therapy; Negative pressure wound therapy
AB Objective: To evaluate the clinical efficacy of Negative Pressure Wound Therapy (NPWT) using Vacuum Assisted Closure (VAC) compared with Advanced Moist Wound Therapy (AMWT) to treat Diabetic Foot Ulcer (DFU).
   Study Design: Randomized control trial.
   Place and Duration of Study: Surgical Department, Combined Military Hospital (CMH) / Military Hospital (MH), Rawalpindi, from November 2010 to June 2012.
   Methodology: The study consisted of 278 patients, with 139 patients each in Group 'A' and 'B', who were subjected to AMWT and NPWT, respectively. Wound was assessed digitally every week for 2 weeks. Wound dimension and surface area were determined using University of Texas Health Centre at San Antonio (UTHCSA) image tool version 3.0. Efficacies of AMWT and NPWT were compared in terms of reduction in wound area over 2 weeks.
   Results: Mean age of presentation in group A was 55.88 +/- 10.97 years while in group B, it was 56.83 +/- 11.3 (p=0.48). Mean duration of diabetes at presentation was 15.65 +/- 4.86 and 15.96 +/- 5.79 years in group A and B, respectively (p=0.74). Majority of patients had Wagner's grade 2 ulcer (82% in group A and 87.8% in group B, p = 0.18). Initial wound size in group A was 15.07 +/- 2.92 cm(2) and in group B 15.09 +/- 2.81 cm(2) (p = 0.95). Wound size measured after 2 weeks, treatment was in group A 13.70 +/- 2.92 cm(2) and in group B 11.53 +/- 2.78 cm(2) (p < 0.001). Wound area reduction in both groups revealed statistically significant faster healing in group B as compared to group A (p < 0.001).
   Conclusion: NPWT using VAC was more efficacious than AMWT in the management of diabetic foot ulcers.
C1 [Sajid, Muhammad Tanveer; Mustafa, Qurat Ul Ain; Shaheen, Neelofar; Hussain, Syed Mukarram; Shukr, Irfan] Combined Mil Hosp, Dept Gen Surg, Rawalpindi, Pakistan.
   [Ahmed, Muhammad] Pak Army, Dept Gen Surg, Rawalpindi, Pakistan.
RP Sajid, MT (通讯作者)，Care of Mustafa HG, Ezzy Traders, Hakeem Jee Bldg,Jinnah Rd, Abbottabad, Pakistan.
EM doc_tanveersajid@hotmail.com
RI Shaheen, Neelofar/ADC-0287-2022
OI Shaheen, Neelofar/0000-0002-2369-5103
CR Abbott CA, 2010, DIABETES CARE, V33, P1325, DOI 10.2337/dc09-2067
   Andrabi Syed Imran Hussain, 2007, J Ayub Med Coll Abbottabad, V19, P89
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   [Anonymous], AHRQ PUBLICATION
   Aragon-Sanchez J, 2009, DIABETES RES CLIN PR, V86, P6
   Mompo JIB, 2011, REV ESP QUIM, V24, P233
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Dzieciuchowicz L, 2009, CIR ESPAN, V86, P213, DOI 10.1016/j.ciresp.2009.06.003
   Fincke BG, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-192
   García-Rodríguez JA, 2007, REV ESP QUIM, V20, P77
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   Paola LD, 2010, J DIABETIC FOOT COMP, V2
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NR 25
TC 39
Z9 52
U1 2
U2 33
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD NOV
PY 2015
VL 25
IS 11
BP 789
EP 793
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CX1OK
UT WOS:000365465300004
PM 26577962
DA 2026-07-24
ER
PT J
AU Hu, C
   Zhang, TG
   Deng, ZM
   Ren, B
   Cai, L
   Zhang, Y
   Yan, L
AF Hu, Chao
   Zhang, Taogen
   Deng, Zhouming
   Ren, Bin
   Cai, Lin
   Zhang, Yi
   Yan, Lei
TI Study on the effect of vacuum sealing drainage on the repair process of
   rabbit sciatic nerve injury
SO INTERNATIONAL JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE vacuum sealing drainage; sciatic nerve; nerve repair
ID PRESSURE WOUND THERAPY; NEUROTROPHIC FACTOR; NEGATIVE-PRESSURE; ASSISTED
   CLOSURE; PERIPHERAL-NERVE; AXONAL REGENERATION; GROWTH-FACTOR; BDNF;
   PROMOTE; BONE
AB Purpose: To investigate the influence of vacuum sealing drainage on sciatic nerve repair after injury in rabbits. Materials and Methods: Twenty four New Zealand white rabbits were randomly divided into experimental group and control group. About 1cm sciatic nerve was transected and sutured back in situ. The experimental group had vacuum sealing drainage assisted wound closure whereas the control group had normal wound closure. The nerve repair rate was compared based on nerve conduction velocity, lower leg triceps wet weight recovery rate, histology, immunohistochemical of brain-derived neurotrophic factor, and ultrastructure observation of regenerated nerve by electron microscopy at the 4th and 8th week after surgery. Results: At the 1st-2nd weeks after surgery, irritation and ulcers were observed on the surgical side in both the experimental group and the control group. At the 4th and 8th week after surgery, electrical nerve conduction velocity in the experimental group was faster than in the control group (p < 0.05) and triceps muscle calf wet weight recovery rate in the experimental group was higher than that in the control group (p < 0.05). Brain-derived neurotrophic factor immunohistochemical staining intensity in the experimental group was higher than that in the control group (p < 0.05) and toluidine blue staining and electron microscopic observation showed that the nerve regeneration and repair were more pronounced in the experimental group as compared to the control group. Myelinated nerve fibers in the experimental group were more than that in the control group at the 4th week and 8th week after surgery. Conclusion: Vacuum sealing drainage facilitates repair of peripheral nerve injury.
C1 [Hu, Chao; Deng, Zhouming; Cai, Lin; Zhang, Yi; Yan, Lei] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Hubei Province, Peoples R China.
   [Zhang, Taogen] Peoples Hosp Daye City, Dept Orthoped, Daye, Hubei Province, Peoples R China.
   [Ren, Bin] Wuhan Univ, Zhongnan Hosp, Dept Radio Chemo Therapy, Wuhan 430071, Hubei Province, Peoples R China.
C3 Wuhan University; Wuhan University
RP Cai, L (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, 169th Donghu Rd, Wuhan 430071, Hubei Province, Peoples R China.
EM guke3559@aliyun.com
RI Li, Caiting/ABD-6818-2021
OI Hu, Chao/0000-0001-9093-2642
FU Fundamental Research Funds for Central Universities [2012303020207]
FX This work is supported by the Fundamental Research Funds for the Central
   Universities (No. 2012303020207).
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NR 27
TC 7
Z9 9
U1 0
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0020-7454
EI 1563-5279
J9 INT J NEUROSCI
JI Int. J. Neurosci.
PD NOV 2
PY 2015
VL 125
IS 11
BP 855
EP 860
DI 10.3109/00207454.2014.979981
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CX3DL
UT WOS:000365575600009
PM 25340255
DA 2026-07-24
ER
PT J
AU Sáez-Martín, LC
   García-Martínez, L
   Román-Curto, C
   Sánchez-Hernández, MV
   Suárez-Fernández, RM
AF Saez-Martin, Luis C.
   Garcia-Martinez, Lourdes
   Roman-Curto, Concepcion
   Sanchez-Hernandez, Miguel V.
   Suarez-Fernandez, Ricardo M.
TI Negative pressure and nanocrystalline silver dressings for nonhealing
   ulcer: A randomized pilot study
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID WOUND THERAPY; BIOFILMS; MANAGEMENT; EFFICACY; SAFETY
AB Chronic wounds have a high prevalence and wound care, treatment, and prevention consume large quantities of resources. Chronic wounds are a growing challenge for clinicians. A prospective randomized pilot study was conducted to assess the effectiveness in terms of reduction in area and safety of the combined use of negative-pressure wound therapy and nanocrystalline silver dressings as compared to negative pressure wound therapy (NPWT) alone in the management of outpatients with chronic wounds. A total of 17 patients were included in the study, 10 were treated with the combined method and 7 with NPWT. Patients were followed for 6 weeks, with a final assessment at 3 months. Clinical improvement, microbiologic data, and toxicity of silver were evaluated. The antibacterial effects of ionic silver together with the development of granulation tissue promoted by NPWT reduced significantly the median extension of the wound between weeks 3 and 6 of treatment. The combination with silver also reduced bacterial colonization with Pseudomonas aeruginosa and the bacterial load on the surface of the wound. The silver levels correlated positively with the extension of the wound, although in none of the patients' toxic levels were reached. The combination of NPWT with nanocrystalline silver dressings was safe and as effective as NPWT alone.
C1 [Saez-Martin, Luis C.; Suarez-Fernandez, Ricardo M.] Gen Univ Hosp Gregorio Maranon, Dept Dermatol, Madrid, Spain.
   [Garcia-Martinez, Lourdes] Univ Hosp Salamanca, Dept Plast Surg, Salamanca, Spain.
   [Roman-Curto, Concepcion] Univ Hosp Salamanca, Dept Dermatol, Salamanca, Spain.
   [Sanchez-Hernandez, Miguel V.] Univ Hosp Salamanca, Dept Anesthesiol, Salamanca, Spain.
C3 General University Gregorio Maranon Hospital; University of Salamanca;
   University of Salamanca
RP Sáez-Martín, LC (通讯作者)，C Doctor Esquerdo 46, E-28007 Madrid, Spain.
EM lcsaezmartin@gmail.com
RI suarez-fernandez, ricardo/D-4201-2014
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   Payne JL, 2009, J BIOMED MATER RES B, V89B, P217, DOI 10.1002/jbm.b.31209
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   Zhao G, 2013, ADV WOUND CARE, V2, P389, DOI 10.1089/wound.2012.0381
NR 23
TC 8
Z9 9
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2015
VL 23
IS 6
BP 948
EP 952
DI 10.1111/wrr.12358
PG 5
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CX5EO
UT WOS:000365725100018
PM 26299899
DA 2026-07-24
ER
PT J
AU Nolff, MC
   Meyer-Lindenberg, A
AF Nolff, Mirja C.
   Meyer-Lindenberg, Andrea
TI Negative pressure wound therapy augmented full-thickness free skin
   grafting in the cat: outcome in 10 grafts transferred to six cats
SO JOURNAL OF FELINE MEDICINE AND SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Objectives The aim of this clinical evaluation was to describe the technique and outcomes of negative pressure wound therapy (NPWT) augmented skin grafting in cats.
   Methods Cats with soft tissue and skin defects (n = 6) underwent open wound management. Wounds were initially covered using a NPWT system that was changed to polyurethane foam dressing once infection was controlled and granulation started. Final closure was achieved after establishment of a healthy, fully granulated wound bed by grafting of free full-thickness skin from the lateral abdominal wall. The freshly grafted skin was then treated with an NPWT dressing at a pressure of -125 mmHg for 3 days, with dressing changes performed daily. Percentage graft take, complications, wound bioburden and cosmetic outcome were recorded.
   Results The mean duration of open wound management was 21.4 days (range 3.0-45.0 days), with a mean duration of NPWT of 8.0 days (range 3.0-14.0 days). Five cats received a single graft, while one cat had five grafts transferred to the right hindlimb. In 7/10 grafts, graft take was 100%, in two grafts take was 95% and in one graft take was 80% (mean take rate 97%). Therapy was well tolerated in all patients. The grafted site displayed normal hair regrowth in four cats, sparse hair regrowth in one and no hair growth at all in one patient. Skin sensation was normal in all grafted patients.
   Conclusions and relevance Skin graft augmentation using NPWT in cats is a feasible option that allows graft fixation, even in anatomically demanding areas. Graft take rate reported here is slightly higher than documented in previous reports.
C1 [Nolff, Mirja C.; Meyer-Lindenberg, Andrea] Univ Munich, Clin Small Anim Surg & Reprod, D-80539 Munich, Germany.
C3 University of Munich
RP Nolff, MC (通讯作者)，Univ Munich, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Germany.
EM m.nolff@lmu.de
RI Nolff, Mirja/W-6756-2019; Meyer-Lindenberg, Andrea/H-1076-2011
OI Nolff, Mirja/0000-0001-9317-7769; Meyer-Lindenberg,
   Andrea/0000-0001-6137-3773
CR [Anonymous], BR J PLAST SURG
   [Anonymous], J AM VET MED ASS
   Azzopardi EA, 2013, ANN PLAS SURG, V70, P23, DOI 10.1097/SAP.0b013e31826eab9e
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NR 17
TC 16
Z9 21
U1 0
U2 20
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1098-612X
EI 1532-2750
J9 J FELINE MED SURG
JI J. Feline Med. Surg.
PD DEC
PY 2015
VL 17
IS 12
BP 1041
EP 1048
DI 10.1177/1098612X15569893
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CX5FH
UT WOS:000365727000010
PM 25656341
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Liu, Y
   Song, J
   Xu, LL
   Huang, XJ
   Lan, HT
   Qin, WG
   Ernest, MER
AF Liu, Yi
   Song, Jian
   Xu, Li-Li
   Huang, Xiao-jun
   Lan, Hai-tao
   Qin, Wen-gang
   Ernest, Mendame Ehya Regis
TI VASCULARIZED FIBULAR GRAFT COMBINED WITH VACUUM ASSISTED CLOSURE IN THE
   RECONSTRUCTION OF TIBIAL DEFECTS
SO AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
LA English
DT Article
DE Tibial defect; Flow-through fibular graft; Vacuum Assisted Closure;
   Chronic Osteomyelitis
ID PRESSURE WOUND THERAPY; BONE DEFECTS; LONG BONES; MANAGEMENT; ALLOGRAFT;
   TUMORS; FLAP; KNEE
AB Background: To investigate the application of Flow-through free vascularized fibular graft combined with Vacuum Assisted Closure for the patients suffering from tibial defects caused by chronic osteomyelitis.
   Methods: We retrospectively analysed 20 cases of patients who accepted this operation in the treatment of tibial defects. Among the tibial defects, six cases resulted from blood stream infection while 14 cases resulted from comminuted fractures. All the patients included in the study were accompanied with 1 to 3 sinuses. The length of the defects ranged from 6cm to 16cm, with an average of 11.3cm. 6 patients were also faced with soft tissues defects combined with tendon or bone exposures, and the defects areas ranged from 11cmx7cm to 19cmx14cm. There were 5 patients suffering from fibular fractures at the same side of the defects. The courses of this disease were 5.5 -15 months, with an average of 9.8 months.
   Results: The patients included in the study were followed up from 10 months to 4 years, with an average of 1.9 years. Sinuses of 18 patients healed within 4 weeks, giving a primary healing rate of 90%. We undertook debridement of the remaining sinuses and they healed within 2 weeks. All skin flaps grafted to the patients survived, thus the survival rate was 100%. The radiographs indicated that 18 patients had good prognosis and the primary union time of grafting fibula were from 4 to 8 months, with average of 6.3 months. The healing patients achieved an average of 25.6 points based on the Enneking evaluation system which was used to evaluate the function of limbs after the operation, indicating that 85.9% of the limb function recovered. 4 patients required revision surgery for complications resulting from the operation: 1 wound breakdown, 2 bone non-unions, 1 graft fracture. Infection occurred only as a pin-tract infection, and was controlled with oral antibiotics and repeated dressing; there was no deep infection out of control in any of these patients.
   Conclusion: The flow-through free vascularized fibular graft did not only repair tibial defects, but retained the continuity of trunk vessels. The flow-through fibular graft combined with Vacuum Assisted Closure (VAC) controlled the infection, shortened the course of treatment, and effectively restored limb function when applied to the treatment of tibial defects.
C1 [Liu, Yi] Hubei Univ Med, Taihe Hosp, Dept Orthoped 5, Shiyan City, Hubei Province, Peoples R China.
   [Song, Jian; Ernest, Mendame Ehya Regis] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Peoples R China.
   [Xu, Li-Li] Hubei Univ Med, Taihe Hosp, Dept Neurol, Shiyan City, Hubei Province, Peoples R China.
   [Huang, Xiao-jun; Lan, Hai-tao] Hubei Univ Med, Dongfeng Hosp, Dept Urol, Shiyan City, Hubei Province, Peoples R China.
   [Qin, Wen-gang] Hubei Univ Med, Dongfeng Hosp, Dept Sci Res & Educ, Shiyan City, Hubei Province, Peoples R China.
C3 Hubei University of Medicine; Wuhan University; Hubei University of
   Medicine; Hubei University of Medicine; Hubei University of Medicine
RP Song, J (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, 169 Donghu Rd, Wuhan 430071, Peoples R China.
EM 731171798@qq.com; songjianwhu@sina.com
OI Mendame ehya, Regis ernest/0000-0003-3275-6649
CR Anagnostakos K, 2012, J WOUND CARE, V21, P333, DOI 10.12968/jowc.2012.21.7.333
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NR 32
TC 3
Z9 3
U1 0
U2 10
PU AFRICAN NETWORKS ETHNOMEDICINES
PI ILE-IFE
PA OBAFEMI AWOLOWO UNIV,CLEMENT O ADEWUNMI, DRUG RES PROD UNIT, FAC
   PHARMACY, ILE-IFE, 00000, NIGERIA
SN 0189-6016
J9 AFR J TRADIT COMPLEM
JI Afr. J. Tradit. Complement. Alt. M.
PY 2015
VL 12
IS 6
BP 27
EP 32
DI 10.4314/ajtcam.v12i6.4
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CX7NG
UT WOS:000365888200004
OA gold
DA 2026-07-24
ER
PT J
AU Hayashi, A
   Komoto, M
   Tanaka, R
   Natori, Y
   Matsumura, T
   Horiguchi, M
   Matsuda, N
   Yoshizawa, H
   Mizuno, H
AF Hayashi, Ayato
   Komoto, Masakazu
   Tanaka, Rica
   Natori, Yuhei
   Matsumura, Takashi
   Horiguchi, Masatoshi
   Matsuda, Norifumi
   Yoshizawa, Hidekazu
   Mizuno, Hiroshi
TI The availability of perifascial areolar tissue graft for deep cutaneous
   ulcer coverage
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Perifascial areolar tissue; Vacuum-assisted closure; Ulcer; Bone
   exposure; Tendon exposure; Deep cutaneous ulcer
ID VACUUM-ASSISTED-CLOSURE; ARTIFICIAL DERMIS; EXPOSED BONE; WOUNDS;
   SURGERY; DEFECTS
AB Soft tissue defects or skin ulcers associated with tendon or bone exposure located distally on the extremities are always difficult to treat. The introduction of the vacuum-assisted closure (VAC) and dermal templates has led to major changes in ulcer treatment strategies. However, it is necessary to find an alternative method to treat these defects when VAC is not available.
   Perifascial areolar tissue (PAT) is the loose connective tissue on the deep fascia that could be a candidate for repairing soft tissue defects or skin ulcers. Grafting PAT on the exposed bone or tendon, including a wide coverage of well-vascularized tissue surrounding the granulation tissue, can prepare the wound to be subsequently closed by a skin graft.
   In this study, the PAT was used in various situations and its optimal usage and outcomes were evaluated. A total of 13 PAT grafts were performed and were especially useful for covering narrow ulcers with narrow tendon exposure and filling fistula areas. In comparison to other cases, covering the exposed cortical bone ulcers seemed to be more difficult to perform. However, an option for these ulcers could be the exposure of bone marrow and usage of intraosseous blood flow. It was also possible for the simultaneous engraftment of PAT and skin in narrow areas and could be an alternative in cases of small concave ulcers or fistulae. The PAT graft is a simple and minimally invasive procedure that can be a good alternative when VAC is not available. (C) 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Hayashi, Ayato; Tanaka, Rica; Horiguchi, Masatoshi; Matsuda, Norifumi; Yoshizawa, Hidekazu; Mizuno, Hiroshi] Juntendo Univ, Sch Med, Dept Plast & Reconstruct Surg, Tokyo 1138421, Japan.
   [Komoto, Masakazu; Matsumura, Takashi] Juntendo Univ, Dept Plast & Reconstruct Surg, Sizuoka Hosp, Shizuoka, Japan.
   [Natori, Yuhei] Kawasakinanbu Hosp, Dept Plast & Reconstruct Surg, Kawasaki, Kanagawa, Japan.
C3 Juntendo University; Juntendo University
RP Hayashi, A (通讯作者)，Juntendo Univ, Sch Med, Dept Plast & Reconstruct Surg, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM ayhayasi@juntendo.ac.jp
FU Grants-in-Aid for Scientific Research [26713051] Funding Source: KAKEN
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brandi C, 2008, J PLAST RECONSTR AES, V61, P1507, DOI 10.1016/j.bjps.2007.09.036
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Eo S, 2011, INT WOUND J, V8, P261, DOI 10.1111/j.1742-481X.2011.00780.x
   Hachiya A, 2010, ANN OTO RHINOL LARYN, V119, P707, DOI 10.1177/000348941011901011
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   Iorio ML, 2012, PLAST RECONSTR SURG, V130, p232S, DOI 10.1097/PRS.0b013e3182615703
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   Koizumi T, 2013, J PLAST SURG HAND SU, V47, P276, DOI 10.3109/2000656X.2012.759955
   Kouraba S., 2003, AHZ J SURG, V73, pA260
   Milcheski DA, 2014, PRS-GLOB OPEN, V2, DOI 10.1097/GOX.0000000000000108
   Moiemen NS, 2001, PLAST RECONSTR SURG, V108, P93, DOI 10.1097/00006534-200107000-00015
   Suzuki S, 2000, BRIT J PLAST SURG, V53, P659, DOI 10.1054/bjps.2000.3426
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   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 16
TC 13
Z9 17
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2015
VL 68
IS 12
BP 1743
EP 1749
DI 10.1016/j.bjps.2015.08.008
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CX7OA
UT WOS:000365890300025
PM 26354999
DA 2026-07-24
ER
PT J
AU Kim, YH
   Hwang, KT
   Kim, JT
   Kim, SW
AF Kim, Y. H.
   Hwang, K. T.
   Kim, J. T.
   Kim, S. W.
TI What is the ideal interval between dressing changes during negative
   pressure wound therapy for open traumatic fractures?
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; flap; open fracture; infection
ID VACUUM-ASSISTED CLOSURE; OPEN TIBIAL FRACTURES; DIABETIC FOOT ULCERS;
   CLINICAL-EXPERIENCE; INFECTION; COVERAGE; IIIB; FLAP
AB Objective: Negative pressure wound therapy (NPWT) is effective in infection control during treatment of severe open fractures. However frequent dressing changes during NPWT are costly and cause patient discomfort. If the interval between dressing changes could be extended, these problems would be reduced. In this article we compare the outcomes of open IIIB fractures with 3-day versus 7-day intervals between dressing changes.
   Method: Patients who sustained Gustilo IIIB open fractures were included. All underwent conventional orthopaedic fixation with delayed latissimus dorsi flap coverage. Group 1 had 3-day intervals between dressing changes and group 2 had 7-day intervals. The final outcomes in the two groups were analysed.
   Results: There were 38 patients in group 1 and 34 patients in group 2. Although the period between admission and final operation was similar in the two groups, the mean number of NPWT changes was 4.54 in 3 day in group 1 and 1.95 in group 2 (p<0.001). This led to a difference in NPWT-related costs; $341.26 in group 1 and $237.49 in group 2(p<0.001). There was no difference in the frequency of complications such as infection or non-union of fractures.
   Conclusion: NPWT is useful treatment option for open fractures, to bridge between initial debridement and final microsurgical tissue transfer. Considering patient comfort, the costs related to the NPWT, and the final flap results, a 7-day interval between changes of the NPWT is acceptable.
   Declaration of interest: The authors have no conflict of interest to declare.
C1 [Kim, Y. H.; Kim, J. T.] Hanyang Univ, Dept Plast & Reconstruct Surg, Coll Med, Seoul 133791, South Korea.
   [Hwang, K. T.] Hanyang Univ, Dept Orthoped Surg, Coll Med, Seoul 133791, South Korea.
   [Kim, S. W.] Seoul Natl Univ, Coll Med, Dept Plast & Reconstruct Surg, Seoul Natl Univ Hosp, Seoul, South Korea.
C3 Hanyang University; Hanyang University; Seoul National University (SNU);
   Seoul National University Hospital
RP Kim, YH (通讯作者)，Hanyang Univ, Dept Plast & Reconstruct Surg, Coll Med, Seoul 133791, South Korea.
EM sw1215@snu.ac.kr
RI ; Hwang, Kyu/R-7249-2016
OI Kim, Sang Wha/0000-0003-0430-3458; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Stansby G, 2010, J WOUND CARE, V19, P496, DOI 10.12968/jowc.2010.19.11.79706
   TUREN CH, 1994, ORTHOP CLIN N AM, V25, P561
   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
   Yao M, 2014, INT WOUND J, V11, P483, DOI 10.1111/j.1742-481X.2012.01113.x
NR 25
TC 18
Z9 21
U1 0
U2 12
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2015
VL 24
IS 11
BP 536
EP 542
DI 10.12968/jowc.2015.24.11.536
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CX7SN
UT WOS:000365902800007
PM 26551646
DA 2026-07-24
ER
PT J
AU Keskin, M
   Bayram, O
   Bulut, T
   Balik, E
AF Keskin, Metin
   Bayram, Onur
   Bulut, Turker
   Balik, Emre
TI Effectiveness of Endoluminal Vacuum-assisted Closure Therapy
   (Endosponge) for the Treatment of Pelvic Anastomotic Leakage After
   Colorectal Surgery
SO SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
LA English
DT Article
ID ENDO-SPONGE TREATMENT; ANTERIOR RESECTION; WOUND CONTROL; EXPERIENCE;
   RECTUM
C1 [Keskin, Metin; Bayram, Onur; Bulut, Turker] Istanbul Univ, Sch Med, Dept Gen Surg, Istanbul, Turkey.
   [Balik, Emre] Koc Univ, Dept Gen Surg, Sch Med, TR-34450 Istanbul, Turkey.
C3 Istanbul University; Koc University
RP Balik, E (通讯作者)，Koc Univ, Dept Gen Surg, Sch Med, TR-34450 Istanbul, Turkey.
EM ebalik@ku.edu.tr
RI BALIK, Emre/C-2438-2014; Bulut, Mehmet/AAY-6153-2020; Keskin,
   Metin/AAY-8567-2020
OI BALIK, Emre/0000-0001-5751-1133; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bemelman WA, 2009, TECH COLOPROCTOL, V13, P261, DOI 10.1007/s10151-009-0543-x
   Fraccalvieri D, 2012, AM J SURG, V204, P671, DOI 10.1016/j.amjsurg.2010.04.022
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   Riss S, 2010, COLORECTAL DIS, V12, pE104, DOI 10.1111/j.1463-1318.2009.01885.x
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NR 17
TC 24
Z9 27
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1530-4515
EI 1534-4908
J9 SURG LAPARO ENDO PER
JI Surg. Laparosc. Endosc. Pct. Tech.
PD DEC
PY 2015
VL 25
IS 6
BP 505
EP 508
DI 10.1097/SLE.0000000000000216
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CY8XR
UT WOS:000366692500010
PM 26551234
DA 2026-07-24
ER
PT J
AU Simonson, DC
   Elliott, AD
   Roukis, TS
AF Simonson, Devin C.
   Elliott, Andrew D.
   Roukis, Thomas S.
TI Catastrophic Failure of an Infected Achilles Tendon Rupture Repair
   Managed with Combined Flexor Hallucis Longus and Peroneus Brevis Tendon
   Transfer
SO CLINICS IN PODIATRIC MEDICINE AND SURGERY
LA English
DT Article
DE Complication; Negative pressure wound therapy; Postoperative infection;
   Skin graft; Tendon transfer
ID RECONSTRUCTION
AB Deep infection is one of the most devastating complications following repair of an Achilles tendon rupture. Treatment requires not only culture-driven antibiotic therapy but, more importantly, appropriate debridement of some or even all of the Achilles tendon. This may necessitate delayed reconstruction of the Achilles tendon. The authors present a successful case of reconstruction of a chronically infected Achilles tendon in an otherwise healthy 43-year-old man via a multistaged approach using the flexor hallucis longus and peroneus brevis tendons. We also provide a brief review of the literature regarding local tendon transfer used in the reconstruction of Achilles tendon rupture.
C1 [Simonson, Devin C.; Roukis, Thomas S.] Gundersen Hlth Syst, Dept Orthopaed, La Crosse, WI 54601 USA.
   [Simonson, Devin C.; Roukis, Thomas S.] Gundersen Hlth Syst, Dept Podiatry, La Crosse, WI 54601 USA.
   [Simonson, Devin C.; Roukis, Thomas S.] Gundersen Hlth Syst, Dept Sports Med, La Crosse, WI 54601 USA.
   [Elliott, Andrew D.] Gunderson Med Fdn, Podiatr Med & Surg Resident PGY 3, La Crosse, WI 54601 USA.
RP Roukis, TS (通讯作者)，Gundersen Hlth Syst, Dept Orthopaed, 1900 South Ave, La Crosse, WI 54601 USA.
EM tsroukis@gundersenhealth.org
CR Ahluwalia R, 2013, FOOT ANKLE SURG, V19, pE7, DOI 10.1016/j.fas.2012.11.003
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NR 14
TC 9
Z9 12
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0891-8422
EI 1558-2302
J9 CLIN PODIATR MED SUR
JI Clin. Podiatr. Med. Surg.
PD JAN
PY 2016
VL 33
IS 1
BP 153
EP +
DI 10.1016/j.cpm.2015.06.006
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CZ0KL
UT WOS:000366793600016
PM 26590732
DA 2026-07-24
ER
PT J
AU Fujii, T
   Kawasaki, M
   Katayanagi, T
   Okuma, S
   Masuhara, H
   Shiono, N
   Watanabe, Y
AF Fujii, Takeshiro
   Kawasaki, Muneyasu
   Katayanagi, Tomoyuki
   Okuma, Shinnosuke
   Masuhara, Hiroshi
   Shiono, Noritsugu
   Watanabe, Yoshinori
TI A Case of an Aortic Abscess around the Elephant Trunk
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE aortic abscess; elephant trunk; prosthetic vascular graft infection;
   vacuum-assisted closure; omental flap
ID STERNAL WOUND-INFECTION; VACUUM-ASSISTED CLOSURE; IN-SITU PRESERVATION;
   GRAFT INFECTIONS; PROSTHETIC GRAFTS; THORACIC AORTA; MANAGEMENT;
   SURGERY; THERAPY
AB A 52-year-old male patient with a history of total arch replacement using the elephant trunk technique for acute aortic dissection 4 years before visited our hospital with the chief complaint of persistent fever. Chest computed tomography (CT) suggested prosthetic vascular graft infection, which was treated surgically after chemotherapy. The first surgery consisted of debridement of an abscess around the vascular graft and in the aorta around the elephant trunk, and thoracic descending aorta replacement and vacuum-assisted closure (VAC) in view of the risk of bleeding from the peripheral region of the elephant trunk. One week later, omental filling was performed as the second step. This is a very rare case of aortic abscess around the elephant trunk that could successfully be managed by graft-conserving treatment.
C1 [Fujii, Takeshiro; Kawasaki, Muneyasu; Katayanagi, Tomoyuki; Okuma, Shinnosuke; Masuhara, Hiroshi; Shiono, Noritsugu; Watanabe, Yoshinori] Toho Univ, Fac Med, Sch Med, Div Cardiovasc Surg,Dept Surg, Tokyo 1438541, Japan.
C3 Toho University
RP Fujii, T (通讯作者)，Toho Univ, Fac Med, Sch Med, Div Cardiovasc Surg,Dept Surg,Ota Ku, 6-11-1 Omorinishi, Tokyo 1438541, Japan.
EM fujiit@med.toho-u.ac.jp
RI MASUHARA, Hiroshi/G-3148-2011
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NR 19
TC 4
Z9 4
U1 0
U2 0
PU MEDICAL TRIBUNE INC
PI TOKYO
PA ED COMM ANNALS THORACIC CARDIOVASCULAR SURG, 2-1-30 KUDAN MINAMI,
   CHIYODA-KU, TOKYO, 102-0074, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2015
VL 21
IS 6
BP 570
EP 573
DI 10.5761/atcs.cr.15-00141
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA CZ0OL
UT WOS:000366805200012
PM 26226888
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hourigan, LA
   Omaye, ST
   Keen, CL
   Jones, JA
   Dubick, MA
AF Hourigan, Leslie A.
   Omaye, Stanley T.
   Keen, Carl L.
   Jones, John A.
   Dubick, Michael A.
TI Vitamin and Trace Element Loss from Negative-Pressure Wound Therapy
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE wound exudate; micronutrients; vitamins; minerals; negative pressure
   wound therapy
ID RETINOL-BINDING-PROTEIN; SURROGATE MEASURE; CRITICALLY-ILL;
   SUPPLEMENTATION; COPPER
AB OBJECTIVE: This study investigated select vitamin and trace element loss from wound exudates in burn and trauma patients treated with negative-pressure wound therapy (NPWT).
   DESIGN: A prospective observational study was performed using wound exudate samples.
   SETTING: A level I trauma center acute care hospital.
   PARTICIPANTS: The study was composed of 8 patients with open abdomens and 9 patients with 12 soft-tissue wounds.
   MAIN OUTCOME MEASURES: The goal was to collect wound exudate samples daily for 3 days, then every other day to day 9 or until NPWT was discontinued, and to analyze for vitamins A (retinol), C, and E and zinc (Zn), iron (Fe), and copper (Cu). Daily loss of each micronutrient was calculated from their concentration and 24-hour volumes of the exudates.
   MAIN RESULTS: Exudate loss in the open-abdomen group was significantly higher than in the patients with soft-tissue wounds (900 547 vs 359 +/- 246 mL/d). The mean 24-hour loss of vitamins A, C, and E were 0.3, 2.8, and 11 mg, respectively, in the open-abdomen group. Over the same period, the losses of Zn, Fe, and Cu were 0.5, 0.4, and 0.25 mg, respectively, in these patients. Micronutrient 24-hour loss was significantly lower in the soft-tissue wound patients than in the open-abdomen group.
   CONCLUSIONS: The data support the concept that significant amounts of micronutrients can be lost from NPWT wound exudates, particularly in open abdomens. These losses should be considered in the nutritional support of these patients who typically are in a hypermetabolic and catabolic state.
C1 [Hourigan, Leslie A.] Brooke Army Med Ctr, San Antonio, TX 78234 USA.
   [Omaye, Stanley T.] Univ Nevada, Dept Agr Nutr & Vet Sci, Reno, NV 89557 USA.
   [Keen, Carl L.] Univ Calif Davis, Nutr & Internal Med, Davis, CA 95616 USA.
   [Jones, John A.] US Army Inst Surg Res, San Antonio, TX USA.
   [Dubick, Michael A.] US Army Inst Surg Res, DCR Res Program, San Antonio, TX USA.
C3 United States Department of Defense; United States Army; Brooke Army
   Medical Center; Nevada System of Higher Education (NSHE); University of
   Nevada Reno; University of California System; University of California
   Davis; United States Department of Defense; United States Army; United
   States Department of Defense; United States Army
RP Hourigan, LA (通讯作者)，Brooke Army Med Ctr, San Antonio, TX 78234 USA.
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NR 32
TC 4
Z9 5
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2016
VL 29
IS 1
BP 20
EP 25
DI 10.1097/01.ASW.0000473680.06666.6a
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA CZ2LP
UT WOS:000366937000004
PM 26650093
DA 2026-07-24
ER
PT J
AU Zhang, TY
   Yan, Y
   Xie, XM
   Mu, WD
AF Zhang, Taiyuan
   Yan, Yan
   Xie, Xinmin
   Mu, Weidong
TI Minimally Invasive Sinus Tarsi Approach With Cannulated Screw Fixation
   Combined With Vacuum-Assisted Closure for Treatment of Severe Open
   Calcaneal Fractures With Medial Wounds
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE Bohler's angle; calcaneus; injury; length of stay; negative pressure;
   open fracture
ID INTERNAL-FIXATION; INTRAARTICULAR FRACTURES; OPEN REDUCTION;
   COMPLICATIONS
AB The aim of our prospective study was to investigate the clinical results and advantages of a minimally invasive sinus tarsi approach with cannulated screw fixation combined with vacuum-assisted closure for the treatment of severe open calcaneal fractures with medial wounds. A total of 31 patients (32 feet) with open calcaneal fractures who were admitted to our hospital from January 2008 to May 2013 were selected for the study and randomly divided into 2 groups: the cannulated screw group (n = 16 patients, 16 feet) and the plate group (n = 15 patients, 16 feet). The Bohler and Gissane angles were compared before and after surgery. The clinical results were evaluated using according to the American Orthopaedic Foot and Ankle Society ankle-hindfoot scale and the rate of infection. The follow-up duration for all patients ranged from 10 to 36 (mean 24) months. No statistically significant differences were found in the radiologic indicators, incidence of early postoperative complications, or American Orthopaedic Foot and Ankle Society ankle-hindfoot scores (p > .05) between the 2 groups. However, a statistically significant difference was seen in the duration of hospitalization (p < .05) between the 2 groups. A minimally invasive sinus tarsi approach with cannulated screw fixation combined with vacuum-assisted closure is an effective method for the treatment of severe open calcaneal fractures with medial wounds. It provides good reduction and requires fewer days of hospitalization. (C) 2016 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Zhang, Taiyuan; Mu, Weidong] Shandong Univ, Shandong Prov Hosp, Dept Traumat Orthopaed, Jinan 250021, Shandong, Peoples R China.
   [Zhang, Taiyuan; Xie, Xinmin] Third Peoples Hosp Jinan, Orthopaed Ctr, Jinan, Peoples R China.
   [Yan, Yan] Third Peoples Hosp Jinan, Dept Paediat, Jinan, Peoples R China.
C3 Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences
RP Mu, WD (通讯作者)，Shandong Univ, Shandong Prov Hosp, Dept Traumat Orthopaed, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
EM 13791035080@139.com
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NR 29
TC 9
Z9 12
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JAN-FEB
PY 2016
VL 55
IS 1
BP 112
EP 116
DI 10.1053/j.jfas.2015.07.023
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA CZ4KF
UT WOS:000367071200025
PM 26372552
DA 2026-07-24
ER
PT J
AU Zhou, ZY
   Liu, YK
   Chen, HL
   Liu, F
AF Zhou, Zhen-Yu
   Liu, Ya-Ke
   Chen, Hong-Lin
   Liu, Fan
TI Prevention of Surgical Site Infection After Ankle Surgery Using
   Vacuum-Assisted Closure Therapy in High-Risk Patients With Diabetes
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE ankle surgery; diabetes mellitus; standard moist wound care; surgical
   site infection; vacuum-assisted closure
ID NEGATIVE-PRESSURE THERAPY; OUTCOMES; FOOT; FRACTURES; MELLITUS
AB Patients with diabetes have a high risk of surgical site infection (SSI) after ankle surgery. The aim of the present study was to investigate the efficacy of vacuum-assisted closure (VAC) in the prevention of SSI after ankle surgery compared with the efficacy of standard moist wound care (SMWC). A retrospective study was performed of unstable ankle fractures for surgical fixation in patients with diabetes from January 2012 to December 2014. VAC and SMWC were used for surgical incision coverage. The primary outcome was the incidence of SSI, and the secondary outcomes were the length of hospital stay and crude hospital costs. The data from 76 patients were analyzed, with 22 (28.95%) in the VAC group and 54 (71.05%) in the SMWC group. The incidence of SSI was 4.6% in the VAC group compared with 27.8% in the SMWC group (chi-square 5.076; p = .024), and the crude odds ratio for SSI in the VAC group was 0.124 (95% confidence interval 0.002 to 0.938). The length of hospital stay was lower in the VAC group than in the SMWC group (12.6 +/- 2.7 days and 15.2 +/- 3.5 days, respectively; t = 3.122, p = .003). The crude hospital costs were also lower in the VAC group than in the SMWC group (Chinese yuan 8643.2 +/- 1195.3 and 9456.2 +/- 1106.3, respectively; t = 2.839, p = .006). After logistic regression analysis, the adjusted odds ratio for the total SSI rate comparing VAC and SMWC was 0.324 (95% confidence interval 0.092 to 0.804; p = .021). Compared with SMWC, VAC can decrease the SSI rate after ankle surgery in patients with diabetes. This finding should be confirmed by prospective, randomized controlled clinical trials. (C) 2016 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Zhou, Zhen-Yu; Liu, Ya-Ke; Liu, Fan] Nantong Univ, Affiliated Hosp, Dept Orthopaed, Nantong, Peoples R China.
   [Chen, Hong-Lin] Nantong Univ, Nantong City 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University
RP Liu, F (通讯作者)，Nantong Univ, Affiliated Hosp, Dept Orthopaed, Xisi Rd 20, Nantong City 226001, Jiangsu, Peoples R China.
EM pphss@126.com
RI ; Chen, Hong-Lin/E-5418-2010
OI Liu, Fan/0000-0002-4967-7595; 
CR Blackham AU, 2013, AM J SURG, V205, P647, DOI 10.1016/j.amjsurg.2012.06.007
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NR 15
TC 19
Z9 21
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JAN-FEB
PY 2016
VL 55
IS 1
BP 129
EP 131
DI 10.1053/j.jfas.2015.08.013
PG 3
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA CZ4KF
UT WOS:000367071200029
PM 26603948
DA 2026-07-24
ER
PT J
AU Poon, H
   Le Cocq, H
   Mountain, AJ
   Sargeant, ID
AF Poon, Henrietta
   Le Cocq, Heather
   Mountain, Alistair J.
   Sargeant, Ian D.
TI Dermal Fenestration With Negative Pressure Wound Therapy: A Technique
   for Managing Soft Tissue Injuries Associated With High-Energy Complex
   Foot Fractures
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE blister; calcaneum; compartment syndrome; dermis; fasciotomy; pilon
   fracture
ID OPERATION ENDURING FREEDOM; IRAQI FREEDOM; BLISTERS; COMPLICATIONS;
   EXPLOSIONS; MANAGEMENT; PATTERNS
AB Military casualties can sustain complex foot fractures from blast incidents. This frequently involves the calcaneum and is commonly associated with mid-foot fracture dislocations. The foot is at risk of both compartment syndrome and the development of fracture blisters after such injuries. The amount of energy transfer and the environment in which the injury was sustained also predispose patients to potential skin necrosis and deep infection. Decompression of the compartments is a part of accepted practice in civilian trauma to reduce the risk of complications associated with significant soft tissue swelling. The traditional methods of foot fasciotomy, however, are not without significant complications. We report a simple technique of dermal fenestration combined with the use of negative pressure wound therapy, which aims to preserve the skin integrity of the foot without resorting to formal fasciotomy. (C) 2016 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Poon, Henrietta; Mountain, Alistair J.; Sargeant, Ian D.] Royal Ctr Def Med, Birmingham, W Midlands, England.
   [Le Cocq, Heather] Leeds Teaching Hosp Natl Hlth Serv Trust, Birmingham B15 2WB, W Midlands, England.
C3 Royal Centre for Defence Medicine
RP Poon, H (通讯作者)，Leeds Teaching Hosp Natl Hlth Serv Trust, Royal Ctr Def Med, Birmingham B15 2WB, W Midlands, England.
EM hpoonie@doctors.net.uk
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NR 28
TC 11
Z9 14
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JAN-FEB
PY 2016
VL 55
IS 1
BP 161
EP 165
DI 10.1053/j.jfas.2015.08.014
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA CZ4KF
UT WOS:000367071200036
PM 26443232
DA 2026-07-24
ER
PT J
AU Sun, XF
   Xie, T
AF Sun, Xiaofang
   Xie, Ting
TI Management of Necrotizing Fasciitis and Its Surgical Aspects
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE necrotizing fasciitis; surgery; debridement; diagnosis; negative
   pressure wound therapy
ID SOFT-TISSUE INFECTIONS; PRESSURE WOUND THERAPY; INTENSIVE-CARE-UNIT;
   FOURNIERS GANGRENE; NEGATIVE-PRESSURE; RETROSPECTIVE ANALYSIS;
   EXPERIENCE; DIAGNOSIS; MORTALITY; CLASSIFICATION
AB Necrotizing fasciitis (NF) is a severe and rapidly progressive infectious disease that attacks superficial an as well as deep fascia, subcutaneous fat tissue, and muscle. Although the incidence is of relatively low frequency, the median mortality is high. NF is a great burden to patients and hospitals. The most common cause of NF is trauma injuries, followed by other conditions with comorbidity. A classification for NF was presented concerning microbial cause, depth of infection, and anatomy. But the value of classification is not convincing. Early diagnosis of NF is essential and still to be realized by far. Information from clinic or laboratory might contribute to the purpose. Surgery is used in exploration debridement and tissue reconstruction as the main method with NF. Negative pressure wound therapy has proved to be useful in improving wound bed preparation and healing.
C1 [Sun, Xiaofang; Xie, Ting] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai 200011, Peoples R China.
C3 Shanghai Jiao Tong University
RP Xie, T (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Wound Healing Dept, Shanghai 200011, Peoples R China.
EM doctortingxie@139.com
FU National Natural Science Foundation of China [81071568, 81272111];
   Translational Medical Research Institute Stem Cells and Regenerative
   Medicine Base in Shanghai Jiao Tong University School of Medicine
   [TS201109]; National Scientific & Technology Pillar Program
   [2012BAI11B04]; Major State Basic Research Development Program of China
   [2012CB518100]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by grants from the National Natural Science Foundation of
   China (81071568, 81272111), Translational Medical Research Institute
   Stem Cells and Regenerative Medicine Base in Shanghai Jiao Tong
   University School of Medicine (TS201109), the National Scientific &
   Technology Pillar Program (2012BAI11B04), and the Major State Basic
   Research Development Program of China (2012CB518100).
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NR 50
TC 16
Z9 23
U1 0
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2015
VL 14
IS 4
BP 328
EP 334
DI 10.1177/1534734615606522
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CZ6WR
UT WOS:000367242200003
PM 26597210
DA 2026-07-24
ER
PT J
AU Bohac, M
   Mikusz, K
   Fedeles, J Sr
AF Bohac, M.
   Mikusz, K.
   Fedeles, J., Sr.
TI Application of negative pressure wound therapy in scalp reconstruction
SO BRATISLAVA MEDICAL JOURNAL
LA English
DT Article
DE scalp reconstruction; negative pressure therapy; polymorbidity
ID VACUUM-ASSISTED CLOSURE; DEFECTS
AB Scalp defects in old polymorbid patients are still therapeutic challenge for reconstructive surgeons. We present the case of a male who underwent an excessive tumour resection with the unsuccessful skin graft coverage. The patient developed a progressive skin graft necrosis and infection with an exposure of calvarial bone. Initial surgical debridement and topical treatment resulted in an excessive bone exposure. We decided to use a negative pressure therapy after multiple bone trephinations, to improve growth of new vital tissue in bone-exposed area. This maneuverer, followed by a split thickness skin graft coverage, allowed a progressive defect healing. In such old polymorbid patient, calvarial bone trephinations with a negative pressure therapy could be considered to achieve effective and considerable results (Fig. 4, Ref. 16). Text in PDF www.elis.sk.
C1 [Bohac, M.; Fedeles, J., Sr.] Comenius Univ, Fac Med, Univ Hosp Bratislava, Dept Plast Surg, SK-82606 Bratislava, Slovakia.
   [Mikusz, K.] Ctr Burns Treatment, Dept Plast Surg, Siemianowice Slaskie, Poland.
C3 Comenius University Bratislava; Slovak Medical University Bratislava
RP Bohac, M (通讯作者)，Comenius Univ, Fac Med, Univ Hosp Bratislava, Dept Plast Surg, Ruzinovska 6, SK-82606 Bratislava, Slovakia.
EM bohac.md@gmail.com
OI Bohac, Martin/0000-0003-4625-1326
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NR 16
TC 3
Z9 3
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2015
VL 116
IS 12
BP 719
EP 721
DI 10.4149/BLL_2015_141
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CZ7LL
UT WOS:000367280800005
PM 26924140
OA Bronze
DA 2026-07-24
ER
PT J
AU Chiara, O
   Cimbanassi, S
   Biffl, W
   Leppaniemi, A
   Henry, S
   Scalea, TM
   Catena, F
   Ansaloni, L
   Chieregato, A
   de Blasio, E
   Gambale, G
   Gordini, G
   Nardi, G
   Paldalino, P
   Gossetti, F
   Dionigi, P
   Noschese, G
   Tugnoli, G
   Ribaldi, S
   Sgardello, S
   Magnone, S
   Rausei, S
   Mariani, A
   Mengoli, F
   di Saverio, S
   Castriconi, M
   Coccolini, F
   Negreanu, J
   Razzi, S
   Coniglio, C
   Morelli, F
   Buonanno, M
   Lippi, M
   Trotta, L
   Volpi, A
   Fattori, L
   Zago, M
   de Rai, P
   Sammartano, F
   Manfredi, R
   Cingolani, E
AF Chiara, Osvaldo
   Cimbanassi, Stefania
   Biffl, Walter
   Leppaniemi, Ari
   Henry, Sharon
   Scalea, Thomas M.
   Catena, Fausto
   Ansaloni, Luca
   Chieregato, Arturo
   de Blasio, Elvio
   Gambale, Giorgio
   Gordini, Giovanni
   Nardi, Guiseppe
   Paldalino, Pietro
   Gossetti, Francesco
   Dionigi, Paolo
   Noschese, Giuseppe
   Tugnoli, Gregorio
   Ribaldi, Sergio
   Sgardello, Sebastian
   Magnone, Stefano
   Rausei, Stefano
   Mariani, Anna
   Mengoli, Francesca
   di Saverio, Salomone
   Castriconi, Maurizio
   Coccolini, Federico
   Negreanu, Joseph
   Razzi, Salvatore
   Coniglio, Carlo
   Morelli, Francesco
   Buonanno, Maurizio
   Lippi, Monica
   Trotta, Liliana
   Volpi, Annalisa
   Fattori, Luca
   Zago, Mauro
   de Rai, Paolo
   Sammartano, Fabrizio
   Manfredi, Roberto
   Cingolani, Emiliano
TI International consensus conference on open abdomen in trauma
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Trauma; open abdomen; negative-pressure wound therapy; enteric fistula;
   definitive abdominal closure
ID PRESSURE WOUND THERAPY; TEMPORARY ABDOMINAL CLOSURE; VACUUM-ASSISTED
   CLOSURE; DAMAGE-CONTROL LAPAROTOMY; EARLY ENTERAL NUTRITION; PLANNED
   VENTRAL HERNIA; FASCIAL CLOSURE; ENTEROATMOSPHERIC FISTULAS;
   ENTEROCUTANEOUS FISTULAS; COMPARTMENT SYNDROME
AB BACKGROUND A part of damage-control laparotomy is to leave the fascial edges and the skin open to avoid abdominal compartment syndrome and allow further explorations. This condition, known as open abdomen (OA), although effective, is associated with severe complications. Our aim was to develop evidence-based recommendations to define indications for OA, techniques for temporary abdominal closure, management of enteric fistulas, and methods of definitive wall closure.
   METHODS The literature from 1990 to 2014 was systematically screened according to PRISMA [Preferred Reporting Items for Systematic Reviews and Meta-analyses] protocol. Seventy-six articles were reviewed by a panel of experts to assign grade of recommendations (GoR) and level of evidence (LoE) using the GRADE [Grading of Recommendations Assessment, Development, and Evaluation] system, and an international consensus conference was held.
   RESULTS OA in trauma is indicated at the end of damage-control laparotomy, in the presence of visceral swelling, for a second look in vascular injuries or gross contamination, in the case of abdominal wall loss, and if medical treatment of abdominal compartment syndrome has failed (GoR B, LoE II). Negative-pressure wound therapy is the recommended temporary abdominal closure technique to drain peritoneal fluid, improve nursing, and prevent fascial retraction (GoR B, LoE I). Lack of OA closure within 8 days (GoR C, LoE II), bowel injuries, high-volume replacement, and use of polypropylene mesh over the bowel (GoR C, LoE I) are risk factors for frozen abdomen and fistula formation. Negative-pressure wound therapy allows to isolate the fistula and protect the surrounding tissues from spillage until granulation (GoR C, LoE II). Correction of fistula is performed after 6 months to 12 months. Definitive closure of OA has to be obtained early (GoR C, LoE I) with direct suture, traction devices, component separation with or without mesh. Biologic meshes are an option for wall reinforcement if bacterial contamination is present (GoR C, LoE II).
   CONCLUSION OA and negative-pressure techniques improve the care of trauma patients, but closure must be achieved early to avoid complications. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.)
C1 [Chiara, Osvaldo; Cimbanassi, Stefania; Sgardello, Sebastian; Mariani, Anna; Lippi, Monica; Trotta, Liliana; Sammartano, Fabrizio] Osped Niguarda Ca Granda, Ctr Trauma, Trauma Surg & Intens Care, Parma, Italy.
   [Negreanu, Joseph] Osped Niguarda Ca Granda, Wound Healing Serv, Parma, Italy.
   [de Rai, Paolo] Policlin Hosp, Gen & Emergency Surg, Milan, Italy.
   [Catena, Fausto; Volpi, Annalisa] Parma Hosp, Emergency Surg & Intens Care, Parma, Italy.
   [Catena, Fausto; Ansaloni, Luca; Magnone, Stefano; Manfredi, Roberto] Papa Giovanni XXIII Hosp, Gen Surg, Bergamo, Italy.
   [Zago, Mauro] Policlin S Pietro Hosp, Gen Surg, Bergamo, Italy.
   [Chieregato, Arturo] Careggi Hosp, Neurosurg Orthoped Anesthesia & Intens Care, Florence, Italy.
   [de Blasio, Elvio; Buonanno, Maurizio] Rummo Hosp, Gen & Emergency Surg & Intens Care, Benvento, Italy.
   [Gambale, Giorgio] Bufalini Hosp, Intens Care, Cesena, Italy.
   [Gordini, Giovanni; Tugnoli, Gregorio; Mengoli, Francesca; di Saverio, Salomone; Coniglio, Carlo] Maggiore Hosp, Trauma Surg & Intens Care, Bologna, Italy.
   [Nardi, Guiseppe; Cingolani, Emiliano] San Camillo Hosp, Shock & Trauma Serv, Rome, Italy.
   [Gossetti, Francesco; Ribaldi, Sergio] Umberto 1 Hosp, Gen Surg, Rome, Italy.
   [Paldalino, Pietro; Fattori, Luca] San Gerardo Hosp, Gen Surg, Monza, Italy.
   [Dionigi, Paolo] San Matteo Hosp, Gen Surg, Pavia, Italy.
   [Nardi, Guiseppe] Cardarelli Hosp, Trauma Surg, Naples, Italy.
   [Castriconi, Maurizio] Cardarelli Hosp, Gen Surg, Naples, Italy.
   [Ribaldi, Sergio] Insubria Univ, Dept Surg, Varese, Italy.
   [Rausei, Stefano] Umberto Parini Hosp, Emergency Surg, Aosta, Italy.
   [Biffl, Walter] Denver Hlth Med Ctr, Trauma & Acute Care Surg, Denver, CO USA.
   [Henry, Sharon; Scalea, Thomas M.] R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA.
   [Leppaniemi, Ari] Meilahti Hosp, Dept Surg, Emergency Surg, Helsinki, Finland.
C3 Ospedale Niguarda Ca' Granda; Ospedale Niguarda Ca' Granda; University
   of Parma; University Hospital of Parma; ASST Papa Giovanni XXIII;
   University of Florence; Azienda Ospedaliero Universitaria Careggi; AUSL
   di Bologna; Sapienza University Rome; University Hospital Sapienza Rome;
   San Gerardo Hospital; IRCCS Fondazione San Matteo; Antonio Cardarelli
   Hospital; Antonio Cardarelli Hospital; University of Insubria; Azienda
   USL della Valle d'Aosta; Denver Health Medical Center; University System
   of Maryland; University of Maryland Baltimore; University of Helsinki;
   Helsinki University Central Hospital
RP Scalea, TM (通讯作者)，22 S Greene St, Baltimore, MD 21201 USA.
EM tscalea@umm.edu
RI Di Saverio, Salomone/G-1437-2012; Leppäniemi, Ari/GQZ-7991-2022; Volpi,
   Annalisa/AHH-5394-2022; Magnone, Stefano/R-6719-2016; Gordini,
   Giovanni/AAB-8170-2022; henry, sharon/JXY-5017-2024; chiara,
   osvaldo/R-6151-2018; Zago, Mauro/O-3387-2015; Dionigi,
   Gianlorenzo/R-4381-2017; Ansaloni, Luca/AAJ-6507-2020; Coccolini,
   Federico/AAJ-6507-2020; coniglio, carlo/AAB-7128-2022; Ansaloni,
   Luca/AAP-9134-2020; Rausei, Stefano/AAM-7898-2021
OI Volpi, Annalisa/0000-0001-5337-9155; Magnone,
   Stefano/0000-0002-8001-3754; chiara, osvaldo/0000-0003-2409-2109; Zago,
   Mauro/0000-0001-9322-0798; Ansaloni, Luca/0000-0001-6427-0307;
   Coccolini, Federico/0000-0001-6364-4186; coniglio,
   carlo/0000-0002-8207-0525; Chieregato, Arturo/0000-0001-6690-8597;
   Sammartano, Fabrizio/0000-0003-4781-0687; Ansaloni,
   Luca/0000-0001-6427-0307; 
FU American Association for the Surgery of Trauma (AAST); Associazione
   Chirurghi Ospedalieri Italiani (ACOI)
FX This study was endorsed by the Trauma Update Network (TUN), European
   Society of Trauma and Emergency Surgery (ESTES), World Society of
   Emergency Surgery (WSES), Societa' Italiana di Anestesia, Analgesia
   Rianimazione e Terapia Intensiva (SIARTI), Societa' Italiana di
   Chirurgia d'Urgenza e del Trauma (SICUT), Societa' Lombarda di Chirurgia
   (SLC), Italian Society of Hernia and Abdominal Wall Surgery (ISHAWS),
   and International Disaster Medicine Association (IDMA). It is also
   supported by representatives of American Association for the Surgery of
   Trauma (AAST), Associazione Chirurghi Ospedalieri Italiani (ACOI).
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NR 79
TC 74
Z9 92
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD JAN
PY 2016
VL 80
IS 1
BP 173
EP 183
DI 10.1097/TA.0000000000000882
PG 11
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA DA1GN
UT WOS:000367544400026
PM 27551925
DA 2026-07-24
ER
PT J
AU Liu, ZF
   Zhao, DW
   Wang, BJ
AF Liu, Zhaofa
   Zhao, Dewei
   Wang, Benjie
TI Improved vacuum sealing drainage in the treatment of gas gangrene: a
   case report
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Gas gangrene; vacuum sealing drainage; treatment
AB In this case, improved vacuum sealing drainage was used for gas gangrene treatment, which is different from traditional therapies of gas gangrene and this is the first report of using improved vacuum sealing drainage to treat gas gangrene. The patient was a 12-year-old Asian Male who was presented to the Emergency Department with a one-day history of left femoral progressing swelling, paining and fevering. Four days ago, rusty iron bars were plugged into the muscle of the left femoral when he played. Then he was taken to the local clinic and injected with tetanus antitoxin. A diagnosis of gas gangrene was made and modified vacuum sealing drainage device was used after thorough debridement. After two weeks' treatment, left femoral was kept and gas gangrene was cured successfully.
C1 [Liu, Zhaofa; Zhao, Dewei; Wang, Benjie] Dalian Univ, Dept Orthopaed, Zhongshan Hosp, 6 Jiefang St, Dalian 116001, Liaoning, Peoples R China.
C3 Dalian University
RP Zhao, DW (通讯作者)，Dalian Univ, Dept Orthopaed, Zhongshan Hosp, 6 Jiefang St, Dalian 116001, Liaoning, Peoples R China.
EM zhaodewdl@sina.com
RI Zhao, Dewei/G-8369-2016
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NR 11
TC 2
Z9 3
U1 0
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 10
BP 19626
EP 19628
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DA3BB
UT WOS:000367669800332
PM 26770624
DA 2026-07-24
ER
PT J
AU Halawi, MJ
   Morwood, MP
AF Halawi, Mohamad J.
   Morwood, Michael P.
TI Acute Management of Open Fractures: An Evidence-Based Review
SO ORTHOPEDICS
LA English
DT Article
ID TIBIAL SHAFT FRACTURES; LONG-BONE FRACTURES; PEDIATRIC POPULATION;
   ANTIBIOTIC-THERAPY; WOUND CLOSURE; INFECTION; DEBRIDEMENT; IRRIGATION;
   CLASSIFICATION; DELAY
AB Open fractures are complex injuries associated with high morbidity and mortality. Despite advances made in fracture care and infection prevention, open fractures remain a therapeutic challenge with varying levels of evidence to support some of the most commonly used practices. Additionally, a significant number of studies on this topic have focused on open tibial fractures. A systematic approach to evaluation and management should begin as soon as immediate life-threatening conditions have been stabilized. The Gustilo classification is arguably the most widely used method for characterizing open fractures. A first-generation cephalosporin should be administered as soon as possible. The optimal duration of antibiotics has not been well defined, but they should be continued for 24 hours. There is inconclusive evidence to support either extending the duration or broadening the antibiotic prophylaxis for type Gustilo type III wounds. Urgent surgical irrigation and debridement remains the mainstay of infection eradication, although questions persist regarding the optimal irrigation solution, volume, and delivery pressure. Wound sampling has a poor predictive value in determining subsequent infections. Early wound closure is recommended to minimize the risk of infection and cannot be substituted by negative-pressure wound therapy. Antibiotic-impregnated devices can be important adjuncts to systemic antibiotics in highly contaminated or comminuted injuries. Multiple fixation techniques are available, each having advantages and disadvantages. It is extremely important to maintain a high index of suspicion for compartment syndrome, especially in the setting of high-energy trauma.
C1 [Halawi, Mohamad J.; Morwood, Michael P.] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC 27710 USA.
C3 Duke University
RP Halawi, MJ (通讯作者)，Duke Univ, Med Ctr, Dept Orthopaed Surg, Box 3000, Durham, NC 27710 USA.
EM mohamad.halawi@dm.duke.edu
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NR 73
TC 81
Z9 108
U1 0
U2 21
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD NOV
PY 2015
VL 38
IS 11
BP E1025
EP E1033
DI 10.3928/01477447-20151020-12
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA DA5JT
UT WOS:000367840100012
PM 26558667
DA 2026-07-24
ER
PT J
AU Morimoto, N
   Kuro, A
   Yamauchi, T
   Horiuchi, A
   Kakudo, N
   Sakamoto, M
   Suzuki, K
   Kusumoto, K
AF Morimoto, Naoki
   Kuro, Atsuyuki
   Yamauchi, Takashi
   Horiuchi, Ai
   Kakudo, Natsuko
   Sakamoto, Michiharu
   Suzuki, Kenji
   Kusumoto, Kenji
TI Combined use of fenestrated-type artificial dermis and topical negative
   pressure wound therapy for the venous leg ulcer of a rheumatoid
   arthritis patient
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Fenestrated-type artificial dermis; Grip tape technique; Negative
   pressure wound therapy; Venous leg ulcer
AB We report a case of circumferential venous leg ulcer in a rheumatoid arthritis patient. Mesh skin grafting was performed in another hospital, but the graft failed and the patient was referred to our hospital. This ulcer was treated by the combination therapy of a fenestrated-type artificial dermis with negative pressure wound therapy (NPWT) and secondary mesh grafting using our 'grip tape technique'. NPWT was started at -100 mmHg and continued until the formation of dermis-like tissue. A section stained using haematoxylin and eosin and an anti-alpha SMA (alpha smooth muscle actin) immunohistological section of the biopsy from dermis-like tissue showed an abundant infiltration of fibroblasts and capillary formation beneath the fenestration of the silicone sheet. Threefold mesh skin grafting was subsequently performed and it was taken up completely. The fenestrated-type artificial dermis in combination with NPWT produced good results without infection in the treatment of complex wounds. In addition, our 'grip tape technique' was useful to apply polyurethane foam to the entire surface of the lower leg.
C1 [Morimoto, Naoki; Kuro, Atsuyuki; Yamauchi, Takashi; Horiuchi, Ai; Kakudo, Natsuko; Kusumoto, Kenji] Kansai Med Univ, Dept Plast & Reconstruct Surg, Hirakata, Osaka 5731010, Japan.
   [Sakamoto, Michiharu] Kyoto Univ, Dept Plast & Reconstruct Surg, Grad Sch Med, Kyoto, Japan.
   [Suzuki, Kenji] Kansai Med Univ, Takii Hosp, Dept Plast & Reconstruct Surg, Moriguchi, Osaka 570, Japan.
C3 Kansai Medical University; Kyoto University; Kansai Medical University
RP Morimoto, N (通讯作者)，Kansai Med Univ, Dept Plast & Reconstruct Surg, 2-5-1 Shin Machi, Hirakata, Osaka 5731010, Japan.
EM morimotn@hirakata.kmu.ac.jp
OI Kakudo, Natsuko/0000-0001-9785-1490; Morimoto, Naoki/0000-0002-0712-3172
CR Baldwin C, 2009, ANN PLAS SURG, V62, P92, DOI 10.1097/SAP.0b013e31817762fd
   Fraccalvieri M, 2012, INT WOUND J, V9, P214, DOI 10.1111/j.1742-481X.2011.00878.x
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NR 11
TC 4
Z9 7
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2016
VL 13
IS 1
BP 137
EP 140
DI 10.1111/iwj.12422
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DA9QH
UT WOS:000368144100024
PM 25650053
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Zhang, DM
   Yang, ZH
   Zhuang, PL
   Wang, YY
   Chen, WL
   Zhang, B
AF Zhang, Da-ming
   Yang, Zhao-hui
   Zhuang, Pei-lin
   Wang, You-yuan
   Chen, Wei-liang
   Zhang, Bin
TI Role of Negative-Pressure Wound Therapy in the Management of
   Submandibular Fistula After Reconstruction for Osteoradionecrosis
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; SYSTEM
AB Purpose: Although negative-pressure wound therapy (NPWT) for complicated wounds has been extensively studied, it is rarely used in cases involving a submandibular fistula due to radiation-induced osteoradionecrosis of the mandible. This study aimed to investigate the efficacy of NPWT for submandibular fistulas after reconstruction for osteoradionecrosis.
   Patients and Methods: Nine patients with submandibular fistulas after reconstruction for osteoradionecrosis treated with NPWT between 2011 and 2014 were included in the study. The wound healing was documented.
   Results: The NPWT device was removed postoperatively between days 7 and 12 (mean duration, 9.6 days). The wound bed was filled with healthy granulation tissue, and successful healing by second intention was observed in all patients within 2 weeks. No complications were observed. The follow-up ranged from 4 to 27 months (mean, 18 months); the fistulas exhibited excellent healing, and no recurrence or infection was observed.
   Conclusions: NPWT is a safe, effective technique for managing submandibular fistulas after reconstruction for osteoradionecrosis. (C) 2016 American Association of Oral and Maxillofacial Surgeons
C1 [Zhang, Da-ming; Yang, Zhao-hui; Zhuang, Pei-lin; Wang, You-yuan; Chen, Wei-liang; Zhang, Bin] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Oral & Maxillofacial Surg, Guangzhou 510120, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Zhang, B (通讯作者)，Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Oral & Maxillofacial Surg, 107 Yan Jiang Rd, Guangzhou 510120, Guangdong, Peoples R China.
EM 158516636@qq.com
CR Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
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NR 15
TC 12
Z9 15
U1 0
U2 18
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
EI 1531-5053
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD FEB
PY 2016
VL 74
IS 2
BP 401
EP 405
DI 10.1016/j.joms.2015.09.012
PG 5
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA DB1KG
UT WOS:000368266500027
PM 26452430
DA 2026-07-24
ER
PT J
AU Alhan, D
   Sahin, I
   Güzey, S
   Aykan, A
   Zor, F
   Öztürk, S
   Nisanci, M
   Özerhan, IH
AF Alhan, Dogan
   Sahin, Ismail
   Guzey, Serbulent
   Aykan, Andac
   Zor, Fatih
   Ozturk, Serdar
   Nisanci, Mustafa
   Ozerhan, Ismail Hakki
TI Staged repair of severe open abdomens due to high-energy gunshot
   injuries with early vacuum pack and delayed tissue expansion and
   dual-sided meshes
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Dual meshes; gunshot injury; open abdomen; tissue expansion; vacuum
   assisted closure
ID ABDOMINAL-WALL RECONSTRUCTION; PLANNED VENTRAL HERNIA; COMPONENTS
   SEPARATION; DEFECTS; CLOSURE; MANAGEMENT; EXPANDERS; TRAUMA; FLAP
AB BACKGROUND: Open abdomen is a salvage procedure that prevents catastrophes after severe intraabdominal traumas. However, following this life saving attempt, it is mostly not feasible to close the abdomen immediately after the recovery of intraabdominal injuries. Consequently, a staged reconstruction is required, and the first stage is usually a temporary closing approach. At the end of this stage, resulting giant "ventral hernia" is a burden for both the patient and the surgeon. Therefore a permanent repair is subsequently needed. Although there are many treatment modalities described for this goal, etiologies like high-energy gunshots may cause an exactly nuisance scene which can limit treatment options and reduce final success. Herein, it was the objective of this study to present our staged protocol to restore the abdominal wall defect and strategy for optimizing the results in such conundrum cases.
   METHODS: Treatment was performed on nine male patients suffering from severe open abdomen due to high-energy gunshot injury. In all patients, temporary closure was provided by negative pressure wound treatment applied directly to the viscera and followed by skin grafting. Late permanent closure was performed with the lamination of expanded abdominal skin and dual-sided meshes.
   RESULTS: The follow-up period ranged between 24 months to 4.5 years (mean, 3 years). During this period, no recurrence of ventral hernia, enteric fistula formation, abdominal infection and seroma formation was observed in any patient.
   CONCLUSION: In this study, NPWT, tissue expansion and dual-sided mesh were used together as a staged procedure for optimizing the results in the clinical scenario of an open abdomen due to high-energy gunshot wound. Results were highly satisfactory for patients and acceptable aesthetically.
C1 [Alhan, Dogan] Eskisehir Mil Hosp, Dept Plast Reconstruct & Aesthet Surg, Eskisehir, Turkey.
   [Sahin, Ismail; Aykan, Andac; Zor, Fatih; Ozturk, Serdar] Gulhane Mil Med Acad, Dept Plast Reconstruct & Aesthet Surg, Ankara, Turkey.
   [Guzey, Serbulent] Kasimpasa Mil Hosp, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkey.
   [Nisanci, Mustafa] Aesthet Surg Ctr, Ankara, Turkey.
   [Ozerhan, Ismail Hakki] Gulhane Mil Med Acad, Dept Gen Surg, Ankara, Turkey.
C3 Eskisehir Military Hospital; Gulhane Training & Research Hospital;
   Kasimpasa Military Hospital; Gulhane Training & Research Hospital
RP Güzey, S (通讯作者)，Kasimpasa Asker Hastanesi, Plast Rekonstrktif & Estet Cerrahi Klin, Istanbul, Turkey.
EM drserbulent@yahoo.com
RI /D-9282-2016; Nişancı, Mustafa/JBJ-1029-2023; Zor, Fatih/B-4818-2017;
   OZERHAN, ISMAIL HAKKI/H-8689-2012
OI Zor, Fatih/0000-0002-5851-0711; OZERHAN, ISMAIL
   HAKKI/0000-0001-7142-9793
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NR 25
TC 5
Z9 5
U1 0
U2 5
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD NOV
PY 2015
VL 21
IS 6
BP 457
EP 462
DI 10.5505/tjtes.2015.05942
PG 6
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA DB1LG
UT WOS:000368269100007
PM 27054636
OA Bronze
DA 2026-07-24
ER
PT J
AU Seo, J
   Kim, J
   Nam, KA
   Zheng, Z
   Oh, BH
   Chung, KY
AF Seo, Jimyung
   Kim, Jihee
   Nam, Kyoung Ae
   Zheng, Zhenlong
   Oh, Byung Ho
   Chung, Kee Yang
TI Reconstruction of large wounds using a combination of negative pressure
   wound therapy and punch grafting after excision of acral lentiginous
   melanoma on the foot
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE acral lentiginous melanoma; negative pressure wound therapy; punch
   grafting; reconstruction; wounds on the feet
ID SKIN
AB Melanoma in darker-pigmented individuals often develops in an acral lentiginous fashion on the foot. After surgical removal of a tumor at this site, repair of the wound can be challenging. This is because there is an insufficient local skin pool and lack of mobility of the skin in this area. Moreover, functional aspects such as walking and weight bearing should be considered. We performed a combination treatment of negative pressure wound therapy (NPWT) and punch grafting on 15 patients, after wide excision of acral lentiginous melanomas on the foot, and compared these to 26 patients who underwent either secondary intention healing (SIH, n = 13) or NPWT (n = 13) alone. The punch grafting with NPWT group showed significantly shorter healing times than those of the other two groups. Evaluation of completely healed wounds using the Vancouver Burn Scar Assessment Scale revealed that the punch grafting group had mean values better, or comparable, to the SIH or NPWT group in four of the five scales (except pigmentation). As for complications, only one patient developed a wound infection after punch grafting. Further, by utilizing NPWT for fixation of punch grafts, it was possible to treat all subjects as outpatients after punch grafting. These results show that a combination treatment of NPWT and punch grafting is an excellent therapeutic option for post-wide excision wounds on the feet, with significantly shortened healing times and favorable cosmetic outcomes.
C1 [Seo, Jimyung; Kim, Jihee; Nam, Kyoung Ae; Zheng, Zhenlong; Oh, Byung Ho; Chung, Kee Yang] Yonsei Univ, Coll Med, Dept Dermatol, Severance Hosp,Cutaneous Biol Res Inst, Seoul 120752, South Korea.
   [Zheng, Zhenlong] Yanbian Univ, Coll Med, Dept Dermatol, Yanji, Peoples R China.
   [Oh, Byung Ho] Keimyung Univ, Coll Med, Dept Dermatol, Daegu, South Korea.
C3 Yonsei University; Severance Hospital; Yonsei University Health System;
   Yanbian University; Keimyung University
RP Chung, KY (通讯作者)，Yonsei Univ, Coll Med, Dept Dermatol, 50 Yonsei Ro, Seoul 120752, South Korea.
EM kychung@yuhs.ac
RI ; Oh, Byung Ho/HLQ-2899-2023
OI Seo, Jimyung/0000-0003-3416-9990; Oh, Byung Ho/0000-0001-9575-5665; Kim,
   Jihee/0000-0002-0047-5941; Chung, Kee Yang/0000-0003-3257-0297
FU National Research Foundation of Korea (NRF) - Ministry of Science, ICT &
   Future Planning [2013R1A2A2A04015894]
FX Statistical assistance was provided by the Biostatistics Collaboration
   Unit, Yonsei University College of Medicine, Seoul, Korea. This research
   was supported by Basic Science Research Program through the National
   Research Foundation of Korea (NRF) funded by the Ministry of Science,
   ICT & Future Planning (No. 2013R1A2A2A04015894).
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NR 23
TC 8
Z9 10
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD JAN
PY 2016
VL 43
IS 1
SI SI
BP 79
EP 84
DI 10.1111/1346-8138.13017
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DB1UT
UT WOS:000368295200014
PM 26173565
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Huang, Q
   Li, JS
   Lau, WY
AF Huang, Qian
   Li, Jieshou
   Lau, Wan-yee
TI Techniques for Abdominal Wall Closure after Damage Control Laparotomy:
   From Temporary Abdominal Closure to Early/Delayed Fascial Closure-A
   Review
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Review
ID NEGATIVE-PRESSURE THERAPY; ACELLULAR DERMAL MATRIX; ASSISTED WOUND
   CLOSURE; AORTIC-ANEURYSM REPAIR; OPEN ABDOMEN TREATMENT; VENTRAL HERNIA
   REPAIR; VACUUM PACK TECHNIQUE; COMPARTMENT SYNDROME; ABSORBABLE MESH;
   BOGOTA BAG
AB Open abdomen (OA) has been an effective treatment for abdominal catastrophes in traumatic and general surgery. However, management of patients with OA remains a formidable task for surgeons. The central goal of OA is closure of fascial defect as early as is clinically feasible without precipitating abdominal compartment syndrome. Historically, techniques such as packing, mesh, and vacuum-assisted closure have been developed to assist temporary abdominal closure, and techniques such as components separation, mesh-mediated traction, bridging fascial defect with permanent synthetic mesh, or biologic mesh have also been attempted to achieve early primary fascial closure, either alone or in combined use. The objective of this review is to present the challenges of these techniques for OA with a goal of early primary fascial closure, when the patient's physiological condition allows.
C1 [Huang, Qian; Li, Jieshou; Lau, Wan-yee] Nanjing Univ, Res Inst Gen Surg, Jinling Hosp, Sch Med, Nanjing 210000, Jiangsu, Peoples R China.
   [Lau, Wan-yee] Chinese Univ Hong Kong, Fac Med, Shatin, Hong Kong, Peoples R China.
C3 Nanjing University; Chinese University of Hong Kong
RP Li, JS (通讯作者)，Nanjing Univ, Res Inst Gen Surg, Jinling Hosp, Sch Med, Nanjing 210000, Jiangsu, Peoples R China.
EM lijieshou1924@sina.com
FU National Science Foundation of China [81370514]
FX This work was supported by the National Science Foundation of China
   (Grant 81370514).
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NR 98
TC 56
Z9 65
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2016
VL 2016
AR 2073260
DI 10.1155/2016/2073260
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DB2GT
UT WOS:000368327000001
PM 26819597
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pang, LM
   Kong, FB
   Wang, XT
   Li, DG
   Li, YB
   Sun, PL
   Huang, HY
   Liu, CQ
   Wei, M
AF Pang, Li-Ming
   Kong, Fan-Biao
   Wang, Xiao-Tong
   Li, De-Gang
   Li, Yu-Bo
   Sun, Ping-Liang
   Huang, Hua-Yong
   Liu, Chun-Qiang
   Wei, Mai
TI Efficacy of Vacuum Sealing Drainage after Incision of Perianal Abscess:
   Preliminary Experience
SO AMERICAN SURGEON
LA English
DT Article
C1 [Pang, Li-Ming; Kong, Fan-Biao; Li, De-Gang; Li, Yu-Bo; Sun, Ping-Liang; Huang, Hua-Yong; Liu, Chun-Qiang] Guangxi Univ Chinese Med, Affiliated Hosp 1, Dept Surg, Nanning 530000, Peoples R China.
   [Wang, Xiao-Tong; Wei, Mai] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Gastrointestinal Surg, Nanning, Peoples R China.
   [Wang, Xiao-Tong; Wei, Mai] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Peripheral Vasc Surg, Nanning, Peoples R China.
C3 Guangxi University of Chinese Medicine
RP Liu, CQ (通讯作者)，Guangxi Univ Chinese Med, Affiliated Hosp 1, Dongge Rd 89-9, Nanning 530000, Peoples R China.
EM liuchunqiang0@163.com
RI Fan-Biao, Kong/IQT-2224-2023; Pang, Liming/OIU-1732-2025
FU Natural Science Foundation of China [81360369, 81360545]
FX This work was supported by grants from the Natural Science Foundation of
   China, No. 81360369 & No. 81360545. Science Foundation for Young
   Scientists of Guangxi University of Chinese Medicine (GZYQJ2014013).
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NR 4
TC 7
Z9 11
U1 0
U2 9
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD NOV
PY 2015
VL 81
IS 11
BP E379
EP E382
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DB4BU
UT WOS:000368458500014
PM 26672572
DA 2026-07-24
ER
PT J
AU Vaidhya, N
   Panchal, A
   Anchalia, MM
AF Vaidhya, Nikunj
   Panchal, Arpit
   Anchalia, M. M.
TI A New Cost-effective Method of NPWT in Diabetic Foot Wound
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; Dressing; Improvised; Cost-effective
ID VACUUM-ASSISTED-CLOSURE; THERAPY
AB Diabetic foot wounds present a great challenge to surgeons. They are difficult to heal and are a significant risk factor for non-traumatic foot amputation besides being a huge financial burden. NPWT systems commercially available (VAC (TM) system, KCI Inc., USA) are costly precluding widespread use. To determine whether negative-pressure wound therapy (NPWT) would afford quicker wound recovery as compared to saline-moistened gauze in the treatment of diabetic foot wounds. Sixty patients were randomized into either the experimental NPWT group or conventional dressing group (control). All patients were given medical therapy for diabetes and antibiotics given according to culture and sensitivity patterns. All foot ulcers were surgically debrided prior to initiation of NPWT or conventional treatment. In the NPWT group, dressings were changed every 48-72 h. In the control group, conventional dressings were applied at the time of surgical debridement and changed twice a day thereafter. End point of study was when wound was ready for either skin grafting or secondary suturing. End point was achieved in the NPWT group in 17.2(SD +/- 3.55) days, compared to 34.9 (SD +/- 5.96) days in the control group (p<0.001). Number of dressing applied were 7.46(SD +/- 2.25) in NPWT group versus 69.8(SD +/- 11.93) in conventional dressing group (p<0.001). Ninety percent cases were successfully treated in NPWT Group as compared to 76.6 % in conventional group. Rate of healing of ulcer is faster in NPWT group as compared to conventional group. Economically modified NPWT is more cost-effective to the patients in our setup.
C1 [Vaidhya, Nikunj; Anchalia, M. M.] Civil Hosp, BJ Med Coll, Dept Gen Surg, Ahmadabad, Gujarat, India.
   [Panchal, Arpit] Govt Med Coll, Dept Gen Surg, Vadodara, India.
C3 B. J. Medical College & Civil Hospital, Ahmedabad
RP Vaidhya, N (通讯作者)，Civil Hosp, BJ Med Coll, Dept Gen Surg, Ahmadabad, Gujarat, India.
EM nikunjvaidhya@gmail.com
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NR 18
TC 32
Z9 37
U1 0
U2 25
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD DEC
PY 2015
VL 77
SU 2
BP S525
EP S529
DI 10.1007/s12262-013-0907-3
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DB5CP
UT WOS:000368531700067
PM 26730058
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Mizuguchi, Y
   Matsumoto, S
   Kan, H
   Koizumi, M
   Kuriyama, S
   Uchida, E
AF Mizuguchi, Yoshiaki
   Matsumoto, Satoshi
   Kan, Hayato
   Koizumi, Michihiro
   Kuriyama, Shou
   Uchida, Eiji
TI Successful Treatment of Necrotizing Fasciitis after Rectal Surgery with
   the Application of a Negative-pressure Wound Therapy: A Case Study
SO JOURNAL OF NIPPON MEDICAL SCHOOL
LA English
DT Article
DE necrotizing fasciitis; negative-pressure wound therapy; colorectal
   cancer; skin grafting
ID VACUUM-ASSISTED CLOSURE; FOURNIERS GANGRENE
AB Introduction: Necrotizing fasciitis (NF) is an aggressive soft tissue infection that involves the deep fascia and is characterized by the extensive deterioration of the surrounding tissue. Immediate recognition and aggressive treatment, including debridement and systemic antibiotics, are mandatory for the successful management of NF. Following radical debridement, closure of the remaining wound can pose significant reconstructive challenges. Accumulating evidence indicates that application of negative-pressure wound therapy (NPWT) is useful in the treatment of patients with severe acute complex wounds, including NF.
   Case Presentation: A 58-year-old man who had undergone surgical resection for rectal carcinoma followed by chemo-radiation therapy developed NF of the pelvis and thigh three years after the surgical procedure. Following extensive debridement, a VAC system was applied to the large open wound and successfully contributed to wound bed cleansing, which was followed by surgery for skin grafting.
   Conclusion: This case demonstrates the successful management of a complex and potentially lethal wound of the perineum to lower leg with debridement and skin grafting as well as with the application of the VAC system.
C1 [Mizuguchi, Yoshiaki; Kan, Hayato; Kuriyama, Shou; Uchida, Eiji] Nippon Med Sch, Dept Gastrointestinal & Hepatobiliary Pancreat Su, Tokyo 1138603, Japan.
   [Matsumoto, Satoshi; Koizumi, Michihiro] Chiba Hokuso Hosp, Nippon Med Sch, Dept Surg, Chiba, Japan.
C3 Nippon Medical School; Nippon Medical School
RP Mizuguchi, Y (通讯作者)，Nippon Med Sch, Dept Gastrointestinal & Hepatobiliary Pancreat Su, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan.
EM m-yoshi@nms.ac.jp
OI Kuriyama, Sho/0000-0001-7055-8032
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Chiummariello S, 2012, G CHIR, V33, P358
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   Wong CH, 2003, J BONE JOINT SURG AM, V85A, P1454, DOI 10.2106/00004623-200308000-00005
   Young Michael H, 2005, Expert Rev Anti Infect Ther, V3, P279, DOI 10.1586/14787210.3.2.279
NR 13
TC 9
Z9 10
U1 0
U2 4
PU MEDICAL ASSOC NIPPON MEDICAL SCH
PI TOKYO
PA 1-1-5, SENDAGI, TOKYO, 113-8602, JAPAN
SN 1345-4676
EI 1347-3409
J9 J NIPPON MED SCH
JI J. Nippon Med. Sch.
PD DEC
PY 2015
VL 82
IS 6
BP 290
EP 294
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DB8GU
UT WOS:000368756000006
PM 26823033
OA gold
DA 2026-07-24
ER
PT J
AU Paradiso, FV
   Nanni, L
   Merli, L
   De Marco, EA
   Catania, VD
   Taddei, A
   Manzoni, C
   Conti, G
AF Paradiso, Filomena Valentina
   Nanni, Lorenzo
   Merli, Laura
   De Marco, Erika Adalgisa
   Catania, Vincenzo Davide
   Taddei, Alessandra
   Manzoni, Carlo
   Conti, Giorgio
TI Vacuum assisted closure for the treatment of complex wounds and
   enterocutaneous fistulas in full term and premature neonates: a case
   report
SO ITALIAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Preterm; Dehiscence; VAC therapy; Enterocutaneous fistula; Plastic
   surgery; Pediatric surgery
ID MANAGEMENT; THERAPY
AB Background: The Vacuum Assisted Closure (VAC) system has become an effective treatment for acute and chronic wound defects. Although its use has been reported in wound care of children and premature infants, the management of the device in this population has not been well established.
   Case presentation: We report the satisfactory results in two neonates (one full-term and one preterm) with complex wounds secondary to major abdominal surgery. In the premature baby an enterocutaneous fistula was also present. Complete epithelialization of the wounds was achieved in both patients within a few weeks thus avoiding any further surgical procedure.
   Case presentation: The use of VAC system in neonates is safe and effective in the management of complex wounds and should be considered as a first line treatment in the event of a major dehiscence.
C1 [Paradiso, Filomena Valentina; Nanni, Lorenzo; Merli, Laura; De Marco, Erika Adalgisa; Catania, Vincenzo Davide; Taddei, Alessandra; Manzoni, Carlo] Univ Cattolica Sacro Cuore, Sch Med, Div Pediat Surg, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
   [Conti, Giorgio] Univ Cattolica Sacro Cuore, Sch Med, Pediat Intens Care Unit, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Paradiso, FV (通讯作者)，Univ Cattolica Sacro Cuore, Sch Med, Div Pediat Surg, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
EM vale.paradiso@gmail.com
RI Catania, Vincenzo Davide/AAH-3310-2020; Paradiso,
   Filomena/OGN-6517-2025; CONTI, Giorgio/AAB-9546-2022
OI Catania, Vincenzo Davide/0000-0002-8387-4680; CONTI,
   Giorgio/0000-0002-8566-9365
CR Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   Gabriel A, 2006, J PEDIATR SURG, V41, P1836, DOI 10.1016/j.jpedsurg.2006.06.050
   Gabriel A, 2009, J PLAST RECONSTR AES, V62, P1428, DOI 10.1016/j.bjps.2008.06.033
   Kilbride KE, 2006, J PEDIATR SURG, V41, P212, DOI 10.1016/j.jpedsurg.2005.10.003
   Lopez G, 2008, J PEDIATR SURG, V43, P2202, DOI 10.1016/j.jpedsurg.2008.08.067
   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Rentea RM, 2013, J SURG RES, V184, P658, DOI 10.1016/j.jss.2013.05.056
   Stoffan AP, 2012, J PEDIATR SURG, V47, P1555, DOI 10.1016/j.jpedsurg.2012.01.014
NR 13
TC 5
Z9 7
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1720-8424
EI 1824-7288
J9 ITAL J PEDIATR
JI Ital. J. Pediatr.
PD JAN 11
PY 2016
VL 42
AR 2
DI 10.1186/s13052-016-0210-6
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA DB8WI
UT WOS:000368797500001
PM 26754964
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Koncar, I
   Cvetkovic, S
   Dragas, M
   Pejkic, S
   Lazovic, G
   Banzic, I
   Zuvela, M
   Markovic, M
   Davidovic, L
AF Koncar, Igor
   Cvetkovic, Slobodan
   Dragas, Marko
   Pejkic, Sinisa
   Lazovic, Goran
   Banzic, Igor
   Zuvela, Marinko
   Markovic, Miroslav
   Davidovic, Lazar
TI Vacuum-assisted wound closure in vascular surgery - clinical and cost
   benefits in a developing country
SO VOJNOSANITETSKI PREGLED
LA English
DT Article
DE surgical wound infection; surgical wound dehiscence; vascular surgical
   procedures; vacuum; socioeconomic factors; treatment outcome
AB Background/Aim. Surgical and chronic wounds in vascular patients might contribute to limb loss and death. Vacuum-assisted closure (VAC) Kinetic Concepts, Inc. (KCI), has been increasingly used in Western Europe and the USA clinical practice for 15 years. Advantages of this method are faster wound healing, wound approximation, lower wound related treatment costs and improved quality of life during treatment. Evidence related to the usage of VAC therapy in vascular patients and cost effectiveness of VAC therapy in a developing country are lacking. The aim of this study was to explore results of VAC therapy in vascular surgery comparing to conventional methods and to test cost effects in a developing country like Serbia. Methods. All patients with wound infection or dehiscence operated at the tertiary vascular university clinic in the period from January 2011 January 2012, were treated with VAC therapy. The primary endpoint was wound closure, while secondary endpoints were hospital stay, the number of weekly dressings, costs of wound care, working time of medical personnel. The patients were divided into groups according to the wound type and location: wound with exposed synthetic vascular implant (25%), laparotomy (13%), foot amputation (29%), major limb amputation (21%), fasciotomy (13%). The results of primary and secondary endpoint were compared with the results of conventional treatment during the previous year. Results. There was one death (1/42, 2.38%) and one limb loss (1/12, 2.38%) in the VAC group, and 8 deaths (8/38, 21.05%) and 5 (5/38, 13.15%) limb losses in the patients treated with conventional therapy. In the VAC group there was one groin bleeding (1/12, 2.38%), one groin reinfection (1/12, 2.38%) and one resistance to therapy with a consequent limb loss. Costs of hospital stay (p < 0.001) and nursing time < 0.001) were reduced with VAC therapy in the group with exposed graft. Conclusion. VAC therapy is the effective method for care of complicated wounds in vascular surgery. Patients with infection of wound with the exposed synthetic graft significantly benefit form this therapy. Cost effectiveness of VAC therapy is applicable to a developing country scenario, however cautious selection of patients contributes to the effectiveness.
C1 [Koncar, Igor; Cvetkovic, Slobodan; Dragas, Marko; Lazovic, Goran; Zuvela, Marinko; Markovic, Miroslav; Davidovic, Lazar] Univ Belgrade, Fac Med, Belgrade, Serbia.
   [Koncar, Igor; Cvetkovic, Slobodan; Dragas, Marko; Pejkic, Sinisa; Banzic, Igor; Markovic, Miroslav; Davidovic, Lazar] Clin Ctr Serbia, Clin Vasc & Endovasc Surg, Dr Kosta Todorovic 8, Belgrade 11000, Serbia.
   [Lazovic, Goran] Clin Ctr Serbia, Clin Plast & Reconstruct Surg, Dr Kosta Todorovic 8, Belgrade 11000, Serbia.
   [Zuvela, Marinko] Clin Ctr Serbia, Clin Digest Surg, Dr Kosta Todorovic 8, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade
RP Koncar, I (通讯作者)，Univ Belgrade, Fac Med, Belgrade, Serbia.; Koncar, I (通讯作者)，Clin Ctr Serbia, Clin Vasc & Endovasc Surg, Dr Kosta Todorovic 8, Belgrade 11000, Serbia.
EM dr.koncar@gmail.com
RI ; Lazovic, Goran/CAI-2428-2022
OI Davidovic, Lazar/0000-0002-0529-2378; Dragas, Marko/0000-0001-9500-9195;
   
FU KCI (Kinetic Concepts Inc) for Serbia, Laviefarm Company
FX The study was supported by representative of KCI (Kinetic Concepts Inc)
   for Serbia, Laviefarm Company, that funded all costs of spent material.
CR Albuquerque MLC, 2000, AM J PHYSIOL-HEART C, V279, pH293, DOI 10.1152/ajpheart.2000.279.1.H293
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
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NR 11
TC 4
Z9 5
U1 0
U2 5
PU MILITARY MEDICAL ACAD-INI
PI BELGRADE
PA CRNOTRAVSKA 17, PO BOX 33-35, BELGRADE, 11040, SERBIA
SN 0042-8450
EI 2406-0720
J9 VOJNOSANIT PREGL
JI Vojnosanit. Pregl.
PD JAN
PY 2016
VL 73
IS 1
BP 9
EP 15
DI 10.2298/VSP13122212K
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC1IE
UT WOS:000368969200002
PM 26964378
DA 2026-07-24
ER
PT J
AU Wang, F
   Liu, S
   Qiu, L
   Ma, B
   Wang, J
   Wang, YJ
   Peszel, A
   Chen, XL
AF Wang, Fei
   Liu, Sheng
   Qiu, Le
   Ma, Ben
   Wang, Jian
   Wang, Yong-Jie
   Peszel, April
   Chen, Xu-Lin
TI Superthin Abdominal Wall Glove-Like Flap Combined With Vacuum-Assisted
   Closure Therapy for Soft Tissue Reconstruction in Severely Burned Hands
   or With Infection
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE burns; hand; VAC; superthin abdominal wall flap; glove-like flap
ID PRESSURE WOUND THERAPY
AB Severe burn and infection to hands always involves the deep structures, such as tendons, joints, and bones. These wounds cannot be closed immediately and therefore creates a high risk for complication. We presented 9 cases with deep dermal burns to the dorsal of the hand (6 electrical burns and 3 thermal crush injuries) with wound infections in 2 cases. The vacuum-assisted closure system was used continuously until the flap reconstruction was performed. A random pattern and superthin abdominal wall skin flap-like glove was designed. The flap was transferred to the defected portion of the dorsum of the hand and resected from the abdominal wall about 3 weeks later. The flaps in 8 of the patients treated by this technique survived completely and partial necrosis of the distal flap occurred in 1 patient. The defect resolved after operative treatment and the function of the hands and fingers were successfully salvaged. All patients resulted in having a satisfactory aesthetic outcome with no or minor discomfort at the abdominal donor area. Integration of the vacuum-assisted closure system and the superthin abdominal wall glove-like flap reconstruction appeared to be successful and should be considered in patients with severely burned hands.
C1 [Wang, Fei; Liu, Sheng; Qiu, Le; Ma, Ben; Wang, Jian; Wang, Yong-Jie; Peszel, April; Chen, Xu-Lin] Anhui Med Univ, Affiliated Hosp 1, Dept Burns, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China.
C3 Anhui Medical University
RP Chen, XL (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Burns, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China.
EM okcxl@126.com
RI ; chen, xu lin/KPY-0747-2024
OI , fei/0000-0001-9449-8361; 
CR Barillo DJ, 2001, BURNS, V27, P613, DOI 10.1016/S0305-4179(01)00014-6
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   Yazar S, 2008, J PLAST RECONSTR AES, V61, P1368, DOI 10.1016/j.bjps.2007.11.045
NR 25
TC 8
Z9 11
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2015
VL 75
IS 6
BP 603
EP 606
DI 10.1097/SAP.0000000000000602
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DC2TT
UT WOS:000369070300007
PM 26418768
DA 2026-07-24
ER
PT J
AU Peters, EJ
   Lipsky, BA
   Aragón-Sánchez, J
   Boyko, EJ
   Diggle, M
   Embil, JM
   Kono, S
   Lavery, LA
   Senneville, E
   Urbancic-Rovan, V
   Van Asten, SA
   Jeffcoate, WJ
AF Peters, E. J.
   Lipsky, B. A.
   Aragon-Sanchez, J.
   Boyko, E. J.
   Diggle, M.
   Embil, J. M.
   Kono, S.
   Lavery, L. A.
   Senneville, E.
   Urbancic-Rovan, V.
   Van Asten, S. A.
   Jeffcoate, W. J.
CA Int Working Grp Diabet Foot
TI Interventions in the management of infection in the foot in diabetes: a
   systematic review
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article; Proceedings Paper
CT 2015 IWGDF Guidance on the Prevention and Management of Foot Problems in
   Diabetes
CY MAY 20-23, 2015
CL The Hague, NETHERLANDS
DE diabetes mellitus; diabetic foot infection; osteomyelitis; antibiotics;
   surgery; systematic review
ID COLONY-STIMULATING FACTOR; SKIN-STRUCTURE INFECTIONS; COMPLICATED SKIN;
   CONTROLLED-TRIAL; PIPERACILLIN-TAZOBACTAM; ANTIBIOTIC-THERAPY;
   OPEN-LABEL; ADJUNCTIVE THERAPY; MULTICENTER; ERTAPENEM
AB The expert panel on diabetic foot infection (DFI) of the International Working Group on the Diabetic Foot conducted a systematic review seeking all published reports relating to any type of treatment for infection of the foot in persons with diabetes published as of 30 June 2014. This review, conducted with both PubMed and EMBASE, was used to update an earlier one undertaken on 30 June 2010 using the same search string. Eligible publications included those that had outcome measures reported for both a treated and a control population that were managed either at the same time, or as part of a before-and-after case design. We did not include studies that contained only information related to definition or diagnosis, but not treatment, of DFI. The current search identified just seven new articles meeting our criteria that were published since the 33 identified with the previous search, making a total of 40 articles from the world literature. The identified articles included 37 randomised controlled trials (RCTs) and three cohort studies with concurrent controls, and included studies on the use of surgical procedures, topical antiseptics, negative pressure wound therapy and hyperbaric oxygen. Among the studies were 15 RCTs that compared outcomes of treatment with new antibiotic preparations compared with a conventional therapy in the management of skin and soft tissue infection. In addition, 10 RCTs and 1 cohort study compared different treatments for osteomyelitis in the diabetic foot. Results of comparisons of different antibiotic regimens generally demonstrated that newly introduced antibiotic regimens appeared to be as effective as conventional therapy (and also more cost-effective in one study), but one study failed to demonstrate non-inferiority of a new antibiotic compared with that of a standard agent. Overall, the available literature was both limited in both the number of studies and the quality of their design. Thus, our systematic review revealed little evidence upon which to make recommendations for treatment of DFIs. There is a great need for further well-designed trials that will provide robust data upon which to make decisions about the most appropriate treatment of both skin and soft tissue infection and osteomyelitis in diabetic patients. Copyright (c) 2016 John Wiley & Sons, Ltd.
C1 [Peters, E. J.; Van Asten, S. A.] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands.
   [Lipsky, B. A.] Univ Hosp Geneva, Geneva, Switzerland.
   [Lipsky, B. A.] Fac Med, Geneva, Switzerland.
   [Lipsky, B. A.] Univ Oxford, Oxford, England.
   [Aragon-Sanchez, J.] La Paloma Hosp, Las Palmas Gran Canaria, Spain.
   [Boyko, E. J.] Seattle Epidemiol Res & Informat Ctr, Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA.
   [Boyko, E. J.] Univ Washington, Seattle, WA 98195 USA.
   [Diggle, M.] Nottingham Univ Hosp Trust, Nottingham, England.
   [Embil, J. M.] Univ Manitoba, Winnipeg, MB, Canada.
   [Kono, S.] Kyoto Med Ctr, Natl Hosp Org, WHO Collaborating Ctr Diabet, Kyoto, Japan.
   [Lavery, L. A.; Van Asten, S. A.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
   [Lavery, L. A.; Van Asten, S. A.] Parkland Hosp, Dallas, TX 75390 USA.
   [Senneville, E.] Gustave Dron Hosp, Tourcoing, France.
   [Urbancic-Rovan, V.] Univ Med Ctr, Ljubljana, Slovenia.
   [Jeffcoate, W. J.] Nottingham Univ Hosp Trust, Nottingham, England.
C3 Vrije Universiteit Amsterdam; Amsterdam University Medical Center;
   University of Geneva; University of Geneva; University of Oxford;
   University of Washington; University of Washington Seattle; University
   of Nottingham; Nottingham University Hospital NHS Trust; University of
   Manitoba; University of Texas System; University of Texas Southwestern
   Medical Center; University Medical Centre Ljubljana; University of
   Nottingham; Nottingham University Hospital NHS Trust
RP Peters, EJ (通讯作者)，Vrije Univ Amsterdam Med Ctr, Dept Internal Med, Room ZH-4A35,POB 7057, NL-1007 MB Amsterdam, Netherlands.
EM e.peters@vumc.nl
RI Aragón-Sánchez, Javier/AAR-9727-2021; Boyko, Edward/G-2484-2017; Diggle,
   Mathew/V-7678-2019; Lipsky, Benjamin A/IZE-0823-2023; Van Asten,
   Suzanne/OYE-3899-2025; Peters, Edgar/B-7790-2014
OI Aragón-Sánchez, Javier/0000-0001-6307-5040; Boyko,
   Edward/0000-0002-3695-192X; Diggle, Mathew/0000-0001-5773-0686; Lavery,
   Lawrence/0000-0002-7920-9952; van Asten, Suzanne/0000-0002-2753-4577;
   Lipsky, Benjamin A/0000-0001-9886-5114; Peters,
   Edgar/0000-0002-3410-1227
FU Innocoll; Osiris; MacroCure; ThermoTrek; Integra; GlaxoSmithKline; KCI;
   Cardinal; Dipexium
FX B. A. L.: Research funding from Innocoll; consulting for Innocoll,
   Merck, Pfizer, Dipexium, Cubist, Cerexa, KCI/Acelity; L. L. is on the
   speaker's bureau for Osiris, Integra, PamLabs, Smit & Nephew; consultant
   for KCI, PamLabs, Innovacyn; Stock ownership in Prizm Medical; received
   research grants from Osiris, MacroCure, ThermoTrek, Integra,
   GlaxoSmithKline, KCI, Cardinal, Dipexium.
CR Duarte HA, 2009, J POPUL THER CLIN PH, V16, pE381
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NR 56
TC 60
Z9 87
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN
PY 2016
VL 32
SU 1
BP 145
EP 153
DI 10.1002/dmrr.2706
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA DC3QP
UT WOS:000369134100014
PM 26344844
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Game, FL
   Apelqvist, J
   Attinger, C
   Hartemann, A
   Hinchliffe, RJ
   Löndahl, M
   Price, PE
   Jeffcoate, WJ
AF Game, F. L.
   Apelqvist, J.
   Attinger, C.
   Hartemann, A.
   Hinchliffe, R. J.
   Londahl, M.
   Price, P. E.
   Jeffcoate, W. J.
CA Int Working Grp Diabet Foot IWGDF
TI Effectiveness of interventions to enhance healing of chronic ulcers of
   the foot in diabetes: a systematic review
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article; Proceedings Paper
CT 2015 IWGDF Guidance on the Prevention and Management of Foot Problems in
   Diabetes
CY MAY 20-23, 2015
CL The Hague, NETHERLANDS
DE diabetes; diabetic foot; ulcer; wound healing; dressing
ID HYPERBARIC-OXYGEN THERAPY; COLONY-STIMULATING FACTOR; RANDOMIZED
   CONTROLLED-TRIAL; PRESSURE WOUND THERAPY; CONTROLLED CLINICAL-TRIAL;
   FIBROBLAST-GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; CRITICAL LIMB
   ISCHEMIA; DOUBLE-BLIND; ELECTRICAL-STIMULATION
AB The outcome of management of diabetic foot ulcers remains a challenge, and there remains continuing uncertainty concerning optimal approaches to management. It is for these reasons that in 2008 and 2012, the International Working Group of the Diabetic Foot (IWGDF) working group on wound healing published systematic reviews of the evidence to inform protocols for routine care and to highlight areas, which should be considered for further study. The same working group has now updated this review by considering papers on the interventions to improve the healing of chronic ulcers published between June 2010 and June 2014. Methodological quality of selected studies was independently assessed by two reviewers using Scottish Intercollegiate Guidelines Network criteria. Selected studies fell into the following ten categories: sharp debridement and wound bed preparation with larvae or hydrotherapy; wound bed preparation using antiseptics, applications and dressing products; resection of the chronic wound; oxygen and other gases, compression or negative pressure therapy; products designed to correct aspects of wound biochemistry and cell biology associated with impaired wound healing; application of cells, including platelets and stem cells; bioengineered skin and skin grafts; electrical, electromagnetic, lasers, shockwaves and ultrasound and other systemic therapies, which did not fit in the aforementioned categories. Heterogeneity of studies prevented pooled analysis of results. Of the 2161 papers identified, 30 were selected for grading following full text review. The present report is an update of the earlier IWGDF systematic reviews, and the conclusion is similar: that with the possible exception of negative pressure wound therapy in post-operative wounds, there is little published evidence to justify the use of newer therapies. Analysis of the evidence continues to present difficulties in this field as controlled studies remain few and the majority continue to be of poor methodological quality.
C1 [Game, F. L.] Derby Teaching Hosp NHS FT, Dept Diabet & Endocrinol, Uttoxeter Rd, Derby DE22 3NE, England.
   [Apelqvist, J.; Londahl, M.] Malmo Univ Hosp, Dept Endocrinol, Malmo, Sweden.
   [Attinger, C.] Medstar Georgetown Univ, Dept Plast Surg, Washington, DC USA.
   [Hartemann, A.] Univ Paris 06, ICAN, Pitie Salpetriere Hosp, APHP, F-75252 Paris 05, France.
   [Hinchliffe, R. J.] St Georges Healthcare NHS Trust, St Georges Vasc Inst, London, England.
   [Price, P. E.] Cardiff Univ, Vice Chancellors Off, Cardiff CF10 3AX, S Glam, Wales.
   [Jeffcoate, W. J.] Nottingham Univ Hosp NHS Trust, Dept Diabet & Endocrinol, Nottingham, England.
C3 Lund University; Skane University Hospital; Georgetown University;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Hopital Universitaire Ambroise-Pare - APHP;
   Sorbonne Universite; City St Georges, University of London; Cardiff
   University; Nottingham University Hospital NHS Trust
RP Game, FL (通讯作者)，Derby Teaching Hosp NHS FT, Dept Diabet & Endocrinol, Uttoxeter Rd, Derby DE22 3NE, England.
EM frances.game@nhs.net
OI Game, Frances/0000-0002-5294-4789; Löndahl, Magnus/0000-0003-1522-3920
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NR 148
TC 158
Z9 186
U1 1
U2 63
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN
PY 2016
VL 32
SU 1
BP 154
EP 168
DI 10.1002/dmrr.2707
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA DC3QP
UT WOS:000369134100015
PM 26344936
OA Bronze
DA 2026-07-24
ER
PT J
AU Markakis, K
   Bowling, FL
   Boulton, AJM
AF Markakis, K.
   Bowling, F. L.
   Boulton, A. J. M.
TI The diabetic foot in 2015: an overview
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article; Proceedings Paper
CT 7th International Symposium on the Diabetic Foot
CY MAY 20-23, 2015
CL The Hague, NETHERLANDS
DE diabetes; foot; overview
ID ENDOTHELIAL PROGENITOR CELLS; PERIPHERAL ARTERIAL-DISEASE;
   HYPERBARIC-OXYGEN THERAPY; CRITICAL LIMB ISCHEMIA; PRESSURE WOUND
   THERAPY; ACUTE CHARCOT FOOT; INTERNATIONAL WORKING GROUP; DOUBLE-BLIND;
   RISK-FACTORS; STEM-CELL
AB In 2015, it can be said that the diabetic foot is no longer the Cinderella of diabetic complications. Thirty years ago there was little evidence-based research taking place on the diabetic foot, and there were no international meetings addressing this topic. Since then, the biennial Malvern Diabetic Foot meetings started in 1986, the American Diabetes Association founded their Foot Council in 1987, and the European Association for the Study of Diabetes established a Foot Study Group in 1998. The first International Symposium on the Diabetic Foot in The Netherlands was convened in 1991, and this was soon followed by the establishment of the International Working Group on the Diabetic Foot that has produced useful guidelines in several areas of investigation and the management of diabetic foot problems. There has been an exponential rise in publications on diabetic foot problems in high impact factor journals, and a comprehensive evidence-base now exists for many areas of treatment. Despite the extensive evidence available, it, unfortunately, remains difficult to demonstrate that most types of education are efficient in reducing the incidence of foot ulcers. However, there is evidence that education as part of a multi-disciplinary approach to diabetic foot ulceration plays a pivotal role in incidence reduction. With respect to treatment, strong evidence exists that offloading is the best modality for healing plantar neuropathic foot ulcers, and there is also evidence from two randomized controlled trials to support the use of negative-pressure wound therapy in complex post-surgical diabetic foot wounds. Hyperbaric oxygen therapy exhibits the same evidence level and strength of recommendation. International guidelines exist on the management of infection in the diabetic foot. Many randomized trials have been performed, and these have shown that the agents studied generally produced comparable results, with the exception of one study in which tigecycline was shown to be clinically inferior to ertapenem +/- vancomycin. Similarly, there are numerous types of wound dressings that might be used in treatment and which have shown efficacy, but no single type (or brand) has shown superiority over others. Peripheral artery disease is another major contributory factor in the development of ulceration, and its presence is a strong predictor of non-healing and amputation. Despite the proliferation of endovascular procedures in addition to open revascularization, many patients continue to suffer from severely impaired perfusion and exhaust all treatment options. Finally, the question of the true aetiopathogenesis of Charcot neuroarthropathy remains enigmatic, although much work is currently being undertaken in this area. In this area, it is most important to remember that a clinically uninfected, warm, insensate foot in a diabetic patient should be considered as a Charcot foot until proven otherwise, and, as such, treated with offloading, preferably in a cast. Copyright (c) 2016 John Wiley & Sons, Ltd.
C1 [Markakis, K.; Bowling, F. L.; Boulton, A. J. M.] Manchester Royal Infirm, Oxford Rd, Manchester M13 9WL, Lancs, England.
   [Bowling, F. L.; Boulton, A. J. M.] Univ Manchester, Manchester, Lancs, England.
C3 University of Manchester; University of Manchester
RP Boulton, AJM (通讯作者)，Manchester Diabet Ctr, 193 Hathersage Rd, Manchester M13 0JE, Lancs, England.
EM ABoulton@med.miami.edu
OI Boulton, Andrew/0000-0001-7856-1201
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NR 141
TC 93
Z9 113
U1 0
U2 43
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN
PY 2016
VL 32
SU 1
BP 169
EP 178
DI 10.1002/dmrr.2740
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA DC3QP
UT WOS:000369134100016
PM 26451519
OA Bronze
DA 2026-07-24
ER
PT J
AU Garwood, CS
   Steinberg, JS
AF Garwood, Caitlin S.
   Steinberg, John S.
TI What's new in wound treatment: a critical appraisal
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article; Proceedings Paper
CT 7th International Symposium on the Diabetic Foot
CY MAY 20-23, 2015
CL The Hague, NETHERLANDS
DE negative pressure wound therapy; amniotic membrane; bioengineered
   alternative tissues; Integra
ID DIABETIC FOOT ULCERS; VACUUM-ASSISTED CLOSURE; MESENCHYMAL STEM-CELLS;
   EQUINUS DEFORMITY; ARTIFICIAL SKIN; ACHILLES-TENDON; PRESSURE; THERAPY;
   INSTILLATION; IMPACT
AB With the growing demand for the specialized care of wounds, there is an ever expanding abundance of wound care modalities available. It is difficult to identify which products or devices enhance wound healing, and thus, a critical and continual look at new advances is necessary. The goal of any wound regimen should be to optimize wound healing by combining basic wound care modalities including debridement, off-loading, and infection control with the addition of advanced therapies when necessary. This review takes a closer look at current uses of negative pressure wound therapy, bioengineered alternative tissues, and amniotic membrane products. While robust literature may be lacking, current wound care advances are showing great promise in wound healing. Copyright (c) 2016 John Wiley & Sons, Ltd.
C1 [Garwood, Caitlin S.] MedStar Georgetown Univ Hosp, 3800 Reservoir Rd NW, Washington, DC USA.
   [Steinberg, John S.] Georgetown Univ, Sch Med, Dept Plast Surg, 3800 Reservoir Rd NW, Washington, DC USA.
   [Steinberg, John S.] MedStar Washington Hosp, Ctr Podiatr Residency, 3800 Reservoir Rd NW, Washington, DC USA.
   [Steinberg, John S.] MedStar Georgetown Univ Hosp, Ctr Wound Healing & Hyperbar Med, 3800 Reservoir Rd NW, Washington, DC USA.
C3 Georgetown University; Georgetown University; MedStar Washington
   Hospital Center; Georgetown University
RP Garwood, CS (通讯作者)，MedStar Georgetown Univ Hosp, 3800 Reservoir Rd NW, Washington, DC USA.
EM Caitlin.garwood@gmail.com
CR [Anonymous], SURG RECONSTRUCTION
   [Anonymous], CLIN PRACT DEV
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NR 65
TC 27
Z9 30
U1 1
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN
PY 2016
VL 32
SU 1
BP 268
EP 274
DI 10.1002/dmrr.2747
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA DC3QP
UT WOS:000369134100030
PM 26452442
OA Bronze
DA 2026-07-24
ER
PT J
AU Arti, H
   Khorami, M
   Ebrahimi-Nejad, V
AF Arti, Hamidreza
   Khorami, Mohsen
   Ebrahimi-Nejad, Vahid
TI Comparison of negative pressure wound therapy (NPWT) & conventional
   wound dressings in the open fracture wounds
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Wound healing; Negative Pressure Wound Therapy; Conventional Wound
   Dressings; Infection
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTION; PREVENTION; INFECTION; COVERAGE
AB Objective: Successful closure is a primary step of treatment in open fracture wounds. Delayed healing or complications can lead to increased treatment duration, costs and disability rates. The aim of this study was to compare Negative Pressure Wound Therapy (NPWT) and conventional wound dressings in patients with open fracture wounds.
   Methods: In a prospective randomized clinical trial study, 90 patients with open fractures that were referred for treatment were enrolled between February 2013 to March 2015. Patients were divided into two groups. Group I underwent NPWT and group II underwent conventional wound dressing. Then patients were followed up for one month. Within the one month, the number of dressing change varied based on the extent of the wound. Duration of wound healing, presence of infection and the number of hospitalization days in these patients were recorded and compared at the end of the study between the two groups. Questionnaires and check lists were used to collect data. Analysis was done with SPSS 20, paired sample T-test, and chi-square tests. P<0.05 was considered significant.
   Results: There was a significant difference between the rate of wound healing in the group one or NPWT group and group II (conventional wound dressings) P<0.05. There was no significant difference between two groups in incidence of infection (P=0.6).
   Conclusion: Using NPWT expedites the healing process of extremity wounds. It is more economical and can be considered as a substitute for the treatment of extremity wounds.
C1 [Arti, Hamidreza; Khorami, Mohsen; Ebrahimi-Nejad, Vahid] Ahvaz Jundishapur Univ Med Sci, Dept Orthoped Surg, Ahvaz, Iran.
   [Arti, Hamidreza; Khorami, Mohsen; Ebrahimi-Nejad, Vahid] Ahvaz Jundishapur Univ Med Sci, Trauma Res Ctr, Sch Med, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS)
RP Arti, H (通讯作者)，Ahvaz Jundishapur Univ Med Sci, Dept Orthoped Surg, Ahvaz, Iran.; Arti, H (通讯作者)，Ahvaz Jundishapur Univ Med Sci, Trauma Res Ctr, Sch Med, Ahvaz, Iran.
EM hamidrezaarti@gmail.com
RI /B-9570-2009
FU Ahwaz Jundishapur University of Medical Sciences
FX We thank Vice Chancellor for research of Ahwaz Jundishapur University of
   Medical Sciences for supporting this research. This paper is derived
   from a specialty thesis of Dr. Vahid Ebrahimi-Nejad resident of
   Orthopaedic Surgery in Ahvaz Jundishapur University of Medical Sciences.
   The authors also thank to Golestan clinical research development unit.
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NR 26
TC 35
Z9 38
U1 1
U2 11
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
EI 1681-715X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD JAN-FEB
PY 2016
VL 32
IS 1
BP 65
EP 69
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC6GN
UT WOS:000369318000015
PM 27022347
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhao, JC
   Xian, CJ
   Yu, JA
   Shi, K
   Hong, L
AF Zhao, Jing-Chun
   Xian, Chun-Jing
   Yu, Jia-Ao
   Shi, Kai
   Hong, Lei
TI Hypertonic Glucose Combined with Negative Pressure Wound Therapy to
   Prepare Wounds with Pseudomonas aeruginosa Infection for Skin
   Grafting: A Report of 3 Cases
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case report; wound; Pseudomonas infections; hypertonic glucose solution
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; SUPER-OXIDIZED
   WATER; IN-VITRO; SALINE SOLUTION; OPEN FRACTURE; BURN PATIENT;
   BLOOD-FLOW; SILVER; EXPERIENCE
AB Soft tissue losses from acute or chronic trauma are a challenge for surgeons. To explore a method to expedite granulation tissue formation in preparation for a split-thickness skin graft (STSG), the medical records of 3 patients - 2 adult men with wounds related to trauma injury and 1 infant with necrotizing fasciitis, all infected with Pseudomonas aeruginosa - were reviewed. All wounds were surgically debrided and managed by applying gauze soaked in 50% glucose followed by continuous negative pressure wound therapy (NPWT) before definitive skin grafting. NPWT pressure was applied at -80 mm Hg for the 2 adult males (ages 39 and 25 years) and -50 mm Hg for the 7-month-old male infant. The dressings were changed every 2 to 3 days. No adverse events occurred, and wounds were successfully closed with a STSG after an average of 7 days. In 1 case, NPWT was able to help affix dressings in a difficult-to-dress area (genital region). The combination of hypertonic glucose and hand-made, gauze-based NPWT was found to be safe, well-tolerated, and effective in preparing the wound bed for grafting. Prospective, randomized, controlled clinical studies are needed to compare the safety, effectiveness, and efficacy of this method to other treatment approaches for P. aeruginosa-infected wounds.
C1 [Zhao, Jing-Chun; Xian, Chun-Jing; Yu, Jia-Ao; Shi, Kai] Jilin Univ, Hosp 1, Burns & Plast Reconstruct Unit, 3302 Jilin Rd, Changchun 130031, Jilin Province, Peoples R China.
   [Shi, Kai; Hong, Lei] Jilin Univ, Hosp 1, Changchun 130031, Jilin Province, Peoples R China.
C3 Jilin University; Jilin University
RP Shi, K (通讯作者)，Jilin Univ, Hosp 1, Burns & Plast Reconstruct Unit, 3302 Jilin Rd, Changchun 130031, Jilin Province, Peoples R China.
EM bu_dong007@163.com
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NR 70
TC 5
Z9 9
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2015
VL 61
IS 6
BP 28
EP 44
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DC8MM
UT WOS:000369473700003
PM 26061405
DA 2026-07-24
ER
PT J
AU Ni, JQ
   Liu, HZ
   Liu, XY
   Zhou, LG
   Sun, YJ
   Shi, P
   Hao, W
   Su, H
   Wang, X
AF Ni, Jianqiang
   Liu, Hongzhi
   Liu, Xiaoyang
   Zhou, Lugang
   Sun, Yujie
   Shi, Peng
   Hao, Wei
   Su, Hao
   Wang, Xin
TI Vacuum Sealing Drainage as Treatment of Severe Buttocks and Perianal
   Infection A Case Report and Review of the Literature
   (Care-Compliant)
SO MEDICINE
LA English
DT Article
ID ASSISTED CLOSURE; WOUNDS
AB Vacuum sealing is a therapeutic concept to achieve secure and rapid wound healing in traumatic soft tissue damage. Its application and effect in the treatment of severe buttocks and perianal infection are unclear.We describe a case of buttocks and perianal infection using the vacuum sealing drainage (VSD) technique. A 58-year-old man was admitted with buttocks and perianal severe infection, which was caused by injection. The size of the wounds was 40x30cm. Colostomy was applied prior to the prompt surgical debridement to prevent defecation and keep the perianal region clean. Emergency debridement was then conducted. After the wounds were thoroughly washed with conventional disinfection solution, they were then covered by VSD system.The infection was controlled 9 days after the first surgery by prompt surgical debridement, the application of VSD treatment, and the use of narrow-spectrum antibiotics based on susceptibility result. After 3 applications of VSD treatment, skin grafting harvested from the left leg was conducted. All free skin grafts survived at 8 weeks. Colon was placed back into the abdominal cavity finally.Initial colostomy and debridement, the temporary VSD cover followed after several days by skin grafting is a reliable treatment regimen for severe buttocks and perianal infection.
C1 [Ni, Jianqiang; Liu, Hongzhi; Liu, Xiaoyang; Zhou, Lugang; Sun, Yujie; Shi, Peng; Hao, Wei; Su, Hao; Wang, Xin] Qingdao Univ, Yuhuangding Hosp, Yantai, Shandong, Peoples R China.
C3 Qingdao University
RP Wang, X (通讯作者)，Qingdao Univ, Yuhuangding Hosp, Yantai, Shandong, Peoples R China.
EM jone-20002@163.com
RI Liu, Hongzhi/LKL-8900-2024
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Etoz A, 2004, TURK PLAST REKONSTR, V12, P102
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NR 9
TC 8
Z9 12
U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT
PY 2015
VL 94
IS 43
AR e1766
DI 10.1097/MD.0000000000001766
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC9IS
UT WOS:000369535500021
PM 26512571
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, TT
   Zhang, LH
   Han, L
   Wang, GQ
   Yin, P
   Li, ZR
   Zhang, LC
   Guo, Q
   Liu, DH
   Tang, PF
AF Li, Tongtong
   Zhang, Lihai
   Han, Li
   Wang, Guoqi
   Yin, Peng
   Li, Zhirui
   Zhang, Licheng
   Guo, Qi
   Liu, Daohong
   Tang, Peifu
TI Early application of negative pressure wound therapy to acute wounds
   contaminated with Staphylococcus aureus: An effective approach to
   preventing biofilm formation
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE acute wound; bacterial contamination; negative pressure wound therapy;
   early application; biofilm prevention
ID PSEUDOMONAS-AERUGINOSA BIOFILM; VACUUM-ASSISTED CLOSURE; IN-VITRO;
   BACTERIAL BIOFILMS; INFLAMMATORY RESPONSES; INFECTED WOUNDS;
   IMMUNE-SYSTEM; MECHANISMS; EPIDERMIDIS; MODEL
AB Negative pressure wound therapy (NPWT) has been demonstrated to be effective at preventing biofilm-associated infections; however, its role in biofilm prevention is unknown. The present study evaluated the effect of NPWT on biofilm prevention when rapidly initiated following wound contamination. Full-thickness dermal wounds (8 mm) were created in rabbit ears and inoculated with green fluorescent protein-labeled Staphylococcus aureus (S. aureus). At 6 h following inoculation, continuous NPWT at -125 mmHg was initiated, with the wounds on the contralateral ear left untreated in order to serve as self-controls. S. aureus rapidly formed mature biofilms in the wound beds post-inoculation, with a persistent bacterial burden of similar to 10(5)-10(7) colony-forming units (CFUs)/wound and impaired wound healing. Compared with the untreated group, NPWT resulted in a significant reduction in biofilm matrix, which was verified by scanning electron microscopy and epifluorescence. A reduction in bacterial counts followed (P<0.05) with similar to 10(3) CFUs/wound on postoperative day 13 and improvement in all healing parameters (P<0.05) relative to control wounds. The results of the present investigation suggest that NPWT is an effective strategy to impeding the formation of S. aureus wound biofilms when initiated rapidly following bacterial contamination. The early application of NPWT, aimed at biofilm prevention, may improve wound care.
C1 [Li, Tongtong; Yin, Peng; Guo, Qi] Nankai Univ, Coll Med, Dept Clin Med, Tianjin 300071, Peoples R China.
   [Li, Tongtong; Zhang, Lihai; Wang, Guoqi; Yin, Peng; Li, Zhirui; Zhang, Licheng; Guo, Qi; Tang, Peifu] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [Han, Li] Chinese PLA Inst Dis Control & Prevent, Ctr Hosp Infect Control, Beijing 100071, Peoples R China.
   [Liu, Daohong] 309 Hosp PLA, Dept Orthoped, Beijing 100091, Peoples R China.
C3 Nankai University; Chinese People's Liberation Army General Hospital
RP Tang, PF (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM tangpeifu301@sina.cn
RI GUO, QI/HSE-6359-2023; Li, Zhirui/OJT-0490-2025
OI Tang, Peifu/0000-0003-4279-1704
FU National Natural Science Foundation of China [81472112]
FX The present study was supported by a grant from the National Natural
   Science Foundation of China (grant no. 81472112).
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NR 51
TC 24
Z9 33
U1 0
U2 27
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAR
PY 2016
VL 11
IS 3
BP 769
EP 776
DI 10.3892/etm.2016.3008
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DC9PV
UT WOS:000369554400011
PM 26997991
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Agrawal, V
   Wilson, K
   Reyna, R
   Emran, MA
AF Agrawal, Vaidehi
   Wilson, Kirby
   Reyna, Roxana
   Emran, Mohammad Ali
TI Feasibility of 4% Topical Lidocaine for Pain Management During Negative
   Pressure Wound Therapy Dressing Changes in Pediatric Patients
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Alternative analgesic; Lidocaine; Negative pressure wound therapy; Pain
   management; Pain reduction
AB BACKGROUND: Opioid analgesics such as morphine are frequently used for pain management in pediatric patients undergoing dressing changes for negative pressure wound therapy (NPWT). While these medications reduce associated pain, they are also associated with adverse side effects ranging from constipation, headache, and dizziness to respiratory depression, chest wall rigidity, and death. Alternative analgesic approaches are needed for pediatric patients undergoing NPWT.
   METHODS: Four percent topical lidocaine was used for pain management during dressing changes for NPWT in a 15-year-old Hispanic male with necrotizing adenopathy.
   CONCLUSION: The 4% topical lidocaine reduced the pain associated with dressing changes during NPWT. No adverse side effects were observed.
C1 [Agrawal, Vaidehi; Emran, Mohammad Ali] Driscoll Childrens Hosp, Dept Surg, 3533 S Alameda St, Corpus Christi, TX 78411 USA.
   [Wilson, Kirby; Reyna, Roxana] Driscoll Childrens Hosp, Nursing Resources, Corpus Christi, TX 78411 USA.
RP Emran, MA (通讯作者)，Driscoll Childrens Hosp, Dept Surg, 3533 S Alameda St, Corpus Christi, TX 78411 USA.
EM mohammad.emran@dchstx.org
RI Agrawal, Vaidehi/B-8282-2019
OI Agrawal, Vaidehi/0000-0002-1958-630X
CR Anand KJS, 2010, PEDIATRICS, V125, pE1208, DOI 10.1542/peds.2009-0489
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   Wong D.L., 2001, Wong's essentials of pediatric nursing
NR 15
TC 6
Z9 7
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD NOV-DEC
PY 2015
VL 42
IS 6
BP 636
EP 638
DI 10.1097/WON.0000000000000189
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA DD1TX
UT WOS:000369705800009
PM 26528875
DA 2026-07-24
ER
PT J
AU Söylemez, MS
   Özkan, K
   Kiliç, B
   Erinç, S
AF Soylemez, Mehmet Salih
   Ozkan, Korhan
   Kilic, Bulent
   Erinc, Samet
TI Intermittent negative pressure wound therapy with instillation for the
   treatment of persistent periprosthetic hip infections: a report of two
   cases
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE negative pressure; vacuum-assisted; periprosthetic infection; hip
ID VACUUM-SEALING-TECHNIQUE; JOINT INFECTIONS; CLOSURE
AB Intermittent negative pressure wound therapy with instillation (NPWTi) is starting to be used successfully to treat early periprosthetic infections of endoprostheses. However, few articles have reported the outcome of treatment with intermittent NPWTi for late persistent periprosthetic infections of the hip. In this study, we report two cases who underwent several rounds of radical wound debridement for the treatment of a late persistent periprosthetic infection of the hip. Intermittent NPWTi was used in both cases. Patients were treated successfully and there was no recurrence after 3 and 1 years of follow-up, respectively.
C1 [Soylemez, Mehmet Salih] Bingol State Hosp, Dept Orthopaed & Traumatol, Kulutr Mahallesi,Oguzhan Caddesi,22, TR-12000 Bingol, Turkey.
   [Ozkan, Korhan] Medeniyet Univ, Fac Med, Dept Orthopaed & Traumatol, Istanbul, Turkey.
   [Kilic, Bulent] Istanbul Gelisim Univ, Orthopaed Surg Clin, Dept Orthopaed & Traumatol, Tekirdag, Turkey.
   [Erinc, Samet] Istanbul Medeniyet Univ, Dept Orthopaed & Traumatol, Goztepe Training & Res Hosp, Istanbul, Turkey.
C3 Bingol State Hospital; Istanbul Medeniyet University; Istanbul Gelisim
   University; Istanbul Goztepe Training & Research Hospital; Istanbul
   Medeniyet University
RP Söylemez, MS (通讯作者)，Bingol State Hosp, Dept Orthopaed & Traumatol, Kulutr Mahallesi,Oguzhan Caddesi,22, TR-12000 Bingol, Turkey.
EM slhsylmz@gmail.com
RI ; Söylemez, Mehmet/AAZ-1399-2020; Kılıç, Bülent/ABB-2651-2021
OI erinç, samet/0000-0002-6494-6415; 
CR Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
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NR 16
TC 14
Z9 16
U1 0
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2016
VL 12
BP 161
EP 166
DI 10.2147/TCRM.S97930
PG 6
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA DD4UE
UT WOS:000369917400001
PM 26929628
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mutafchiyski, VM
   Popivanov, GI
   Kjossev, KT
   Chipeva, S
AF Mutafchiyski, Ventsislav M.
   Popivanov, G. I.
   Kjossev, K. T.
   Chipeva, S.
TI Open abdomen and VAC® in severe diffuse peritonitis
SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS
LA English
DT Article
DE SURGERY; WOUND MANAGEMENT
ID ASSISTED FASCIAL CLOSURE; MANAGEMENT; SYSTEMS
AB Background Currently, the open abdomen technique is the widely recognised method for treatment of life-threatening trauma, intra-abdominal sepsis, abdominal compartment syndrome and wound dehiscence. The techniques for temporary closure using negative pressure have gained increasing popularity. Although negative pressure wound therapy has been proved as an effective method in trauma, the results in diffuse peritonitis are contradictory.
   Methods Overall, 108 patients with diffuse peritonitis and open abdomen were prospectively enrolled from January 2006 to December 2013-69 treated with mesh-foil laparostomy without negative pressure and 49 with vacuum-assisted closure (VAC (R)) The primary endpoints were the rate of primary fascial closure and mortality. The secondary outcomes were the rate of complications-enteroatmospheric fistulas, intra-abdominal abscesses, wound infection and necrotising fasciitis, intensive care unit (ICU) and overall hospital stay.
   Results VAC was associated with higher overall (73% vs 53%) and late primary fascial closure rates (31% vs 7%), lower rates of necrotising fasciitis (2% vs 15%, p=0.012), intra-abdominal abscesses (10% vs 20%), enteroatmospheric fistulas (8% vs 19%), overall mortality (31% vs 53%, p<0.05), shorter ICU (6.1 vs 10.6days, p=0.002) and hospital stay (15.1 vs 25.9days, p=0.000).
   Conclusions The results clearly suggest the obvious advantage of VAC in comparison to the temporary abdominal closure without negative pressure in the cases with severe diffuse peritonitis. However, to a large extent, our results might be attributed to the combination of VAC with dynamic fascial closure.
C1 [Mutafchiyski, Ventsislav M.] Mil Med Acad, Dept Mil Surg, Clin Endoscop Endocrine Surg & Coloproctol, Sofia 1606, Bulgaria.
   [Popivanov, G. I.] Mil Med Acad, Clin Endoscop Endocrine Surg & Coloproctol, Sofia 1606, Bulgaria.
   [Kjossev, K. T.] Mil Med Acad, Clin Abdominal Surg, Sofia 1606, Bulgaria.
   [Chipeva, S.] Univ Natl & World Econ, Dept Stat & Econometr, Sofia, Bulgaria.
C3 Military Medical Academy Sofia; Military Medical Academy Sofia; Military
   Medical Academy Sofia; University of National & World Economics -
   Bulgaria
RP Popivanov, GI (通讯作者)，Mil Med Acad, 3 Georgi Sofijski Str, Sofia 1606, Bulgaria.
EM gerasimpopivanov@rocketmail.com
RI Popivanov, Georgi/IVH-4670-2023; Kjossev, Kirien/KQV-3036-2024
CR [Anonymous], 2000, ACTA CHIRURG AUSTRIA
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NR 25
TC 24
Z9 31
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0035-8665
EI 2052-0468
J9 J ROY ARMY MED CORPS
JI J. R. Army Med. Corps
PD FEB
PY 2016
VL 162
IS 1
BP 30
EP 34
DI 10.1136/jramc-2014-000386
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DD6BV
UT WOS:000370009600007
PM 25712560
DA 2026-07-24
ER
PT J
AU Lectercq, A
   Labeille, B
   Perrot, JL
   Vercherin, P
   Cambazard, F
AF Lectercq, A.
   Labeille, B.
   Perrot, J. -L.
   Vercherin, P.
   Cambazard, F.
TI Skin graft secured by VAC (vacuum-assisted closure) therapy in chronic
   leg ulcers: A controlled randomized study
SO ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
LA English
DT Article
DE VAC therapy; Chronic leg ulcer; Skin graft; Vacuum-associated closure
ID NEGATIVE-PRESSURE THERAPY; CONTROLLED-TRIAL
AB Introduction. - Leg ulcers are a common condition. There have been very few studies of combined therapy involving VAC (vacuum-assisted closure) and skin graft.
   Methods. - We performed a randomized controlled trial of VAC therapy vs. hydrocolloid dressings over 5 days following autologous grafting on chronic leg ulcers. The primary objective was to assess the difference in success (defined as a reduction in wound area of at least 50% at 1 month) between the two dressing methods. Forty-six patients with ulcers present for over one month were included. Following a 7-day hospitalization period, follow-up was performed for 3 months on an outpatient basis.
   Results. - Our study does not demonstrate a statistically significant difference, with a 45.8% success rate in the VAC group vs. 40.9% in the conventional dressing group (P = 0.73). In the venous ulcer group, the success rate was 57.9% for VAC vs. 40% for conventional dressings (P = 0.3). The difference in favor of VAC in this group was not statistically significant, most likely due to an insufficient number of patients studied.
   Conclusion. - Our study does not demonstrate superiority of VAC associated with skin graft over conventional dressings. We observed more complications with VAC (40%) than with conventional dressings (23%) (P = 0.06). (C) 2015 Elsevier Masson SAS. All rights reserved.
C1 [Lectercq, A.; Labeille, B.; Perrot, J. -L.; Cambazard, F.] CHU St Etienne, Hop Nord, Dept Dermatol, F-42055 St Etienne 2, France.
   [Vercherin, P.] CHU St Etienne, Hop Nord, Dept Publ Hlth & Med Informat, F-42055 St Etienne 2, France.
C3 CHU de St Etienne; CHU de St Etienne
RP Labeille, B (通讯作者)，CHU St Etienne, Hop Nord, Dept Dermatol, F-42055 St Etienne 2, France.
EM bruno.labeille@chu-st-etienne.fr
CR Barwell JR, 2004, LANCET, V363, P1854, DOI 10.1016/S0140-6736(04)16353-8
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   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Mouës CM, 2011, AM J SURG, V201, P544, DOI 10.1016/j.amjsurg.2010.04.029
   Polignano R, 2004, J Wound Care, V13, P21
   Teot L, 2006, J Wound Care, V15, P355
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   WHEELAND RG, 1987, J DERMATOL SURG ONC, V13, P873, DOI 10.1111/j.1524-4725.1987.tb00564.x
NR 12
TC 17
Z9 22
U1 0
U2 11
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0151-9638
EI 2214-5451
J9 ANN DERMATOL VENER
JI Ann. Dermatol. Venereol.
PD JAN
PY 2016
VL 143
IS 1
BP 3
EP 8
DI 10.1016/j.annder.2015.06.022
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DD8OQ
UT WOS:000370186900002
PM 26718899
DA 2026-07-24
ER
PT J
AU Santarpino, G
   Gazdag, L
   Sirch, J
   Vogt, F
   Ledwon, M
   Fischlein, T
   Pfeiffer, S
AF Santarpino, Giuseppe
   Gazdag, Lazlo
   Sirch, Joachim
   Vogt, Ferdinand
   Ledwon, Miroslaw
   Fischlein, Theodor
   Pfeiffer, Steffen
TI A Retrospective Study to Evaluate Use of Negative Pressure Wound Therapy
   in Patients Undergoing Bilateral Internal Thoracic Artery Grafting
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE retrospective study; postoperative complications; surgical wound
   infection; anastomosis internal mammary-coronary artery
ID INCISION MANAGEMENT-SYSTEM; VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY;
   PREVENTION; EXPERIENCE; INFECTION
AB Bilateral internal thoracic artery (BITA) grafting may be associated with a higher risk of postoperative deep sternal wound infection than monolateral internal thoracic artery grafting due to a limited blood supply to the thoracic chest wall. Because preliminary studies suggest negative pressure wound therapy (NPWT) may reduce the risk of infection, a retrospective chart review of 129 patients who underwent BITA between February 2003 and October 2014 was conducted. Of those, 21 patients received NPWT for 5 days immediately following surgery and the incisions of 108 patients were covered with a conventional gauze dressing. Patient demographic and history variables as well as surgical procedure and outcome variables were abstracted. Outcome variables assessed included infection, need for transfusion, and length of hospital stay. The NPWT group was significantly younger (average age 55.9 +/- 7.6 versus 60 +/- 10.5 years, P = 0.049), had fewer urgent/emergent surgeries (4 [19%] versus 36 [33.3%], P = 0.247), and had significantly lower surgical risk scores (2.0 +/- 2.3 versus 3.8 +/- 2.8, P = 0.010). The rate of deep sternal wound infections was lower in the NPWT than in the control group, but the difference was not statistically significant (0% versus 5.6%, P = 0.336). Sternal instability was noted in 4 control patients, requiring wound re-exploration versus 0 in the NPWT group (3.7% versus 0%, P = 0.487). One (1) patient in the NPWT group had postoperative bleeding that required removal of the device. The rates of re-thoracotomy due to bleeding were 9.3% in the control compared to 4.8% in the NPWT group (P = 0.435), which translated into a greater need for blood transfusions (1.77 +/- 3.4 units versus 0.3 3 +/- 0.7 units, P = 0.056) and larger chest drainage volume (997.8 +/- 710 mL versus 591.2 +/- 346 mL, P = 0.012) in the control group. Hospital stay was longer in the control group, but the difference was not statistically significant (12 +/- 8.8 days versus 9.4 +/- 4.2 days, P = 0.184). These preliminary results are encouraging, and prospective, randomized, controlled clinical studies to compare the efficacy, effectiveness, and cost-effectiveness of NPWT to other wound management modalities following cardiac surgery are warranted.
C1 [Santarpino, Giuseppe; Fischlein, Theodor; Pfeiffer, Steffen] Paracelsus Med Univ, Klinikum Nurnberg, Dept Cardiac Surg, Cardiovasc Ctr,Cardiac Surg, Nurnberg, Germany.
   [Santarpino, Giuseppe; Gazdag, Lazlo; Sirch, Joachim; Vogt, Ferdinand; Ledwon, Miroslaw] Paracelsus Med Univ, Klinikum Nurnberg, Dept Cardiac Surg, Cardiovasc Ctr, Breslauer Str 201, D-90471 Nurnberg, Germany.
C3 Klinikum Nurnberg; Klinikum Nurnberg
RP Santarpino, G (通讯作者)，Paracelsus Med Univ, Klinikum Nurnberg, Dept Cardiac Surg, Cardiovasc Ctr, Breslauer Str 201, D-90471 Nurnberg, Germany.
EM giuseppe.santarpino@klinikum-nuernberg.de
RI Vogt, Ferdinand/AAN-4881-2021; Santarpino, Giuseppe/H-8678-2013
OI Vogt, Ferdinand/0000-0002-1924-6823; Santarpino,
   Giuseppe/0000-0002-4913-9834
CR Atkins BZ, 2011, INT WOUND J, V8, P56, DOI 10.1111/j.1742-481X.2010.00743.x
   Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
   Berdajs D, 2006, ANN THORAC SURG, V81, P2155, DOI 10.1016/j.athoracsur.2006.01.020
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   ElBardissi AW, 2012, J THORAC CARDIOV SUR, V143, P273, DOI 10.1016/j.jtcvs.2011.10.029
   Grauhan O, 2013, J THORAC CARDIOV SUR, V145, P1387, DOI 10.1016/j.jtcvs.2012.09.040
   Ingargiola Michael J, 2013, Eplasty, V13, pe49
   Masden D, 2012, ANN SURG, V255, P1043, DOI 10.1097/SLA.0b013e3182501bae
   Matatov T, 2013, J VASC SURG, V57, P791, DOI 10.1016/j.jvs.2012.09.037
   Petzina R, 2006, EUR J CARDIO-THORAC, V30, P85, DOI 10.1016/j.ejcts.2006.04.009
   Saso S, 2010, ANN THORAC SURG, V89, P661, DOI 10.1016/j.athoracsur.2009.08.018
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
   Wu YC, 2015, J DIABETES
   Zhou Z. H., 2010, Journal of Medical Engineering & Technology, V34, P285, DOI 10.3109/03091901003753041
NR 15
TC 12
Z9 12
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD DEC
PY 2015
VL 61
IS 12
BP 26
EP 30
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DD9JB
UT WOS:000370240400005
PM 27763880
DA 2026-07-24
ER
PT J
AU Hao, S
   Juan, L
   Xin, W
AF Hao, S.
   Juan, L.
   Xin, W.
TI Treatment of traumatically cutaneous necrosis of buttocks using vacuum
   sealing drainage combined with ileostomy
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Vacuum sealing drainage (VSD); Cutaneous necrosis; Skin transplantation;
   Ileostomy
ID ASSISTED CLOSURE; WOUND-INFECTION; THERAPY
AB The purpose of this study is to evaluate the surgical technique and review the therapeutic effect of vacuum sealing drainage combined with ileostomy treating patients of traumatically buttock skin necrosis.
   26 patients with buttock wounds were dressed and 6-12 days later, buttock skin necrosis boundaries were clear and debridement was performed. General surgeons were invited to perform the ileostomy. Thorough debridement was conducted and vacuum sealing drainage (VSD) devices were used to cover buttock wounds. Debridement and VSD were operated every 5-7 days until the granulation tissue of buttock wound was fresh. Then epidermal skin graft from thigh was performed to cover the granulation wound. About 3 months later after skin graft survival completely, the ileum was reversed by general surgeons and the patients recovered defecation using anus.
   The granulation tissues of all patients were fresh after debridement and VSD 2-3 times. In 20 cases, transplanted epidermal skin grew well. In six cases, necrosis was observed at the margins of the flap and further debridement and skin graft were conducted. During the follow-up period of approximate 6 months, the flaps grew well and the patients defecated normally from anus.
   Treating traumatically cutaneous necrosis of buttocks with vacuum sealing drainage and ileostomy can gain good therapeutic effect.
C1 [Hao, S.; Xin, W.] Yantai Yuhuangding Hosp, Dept Traumat Orthopaed, Yantai, Shandong, Peoples R China.
   [Juan, L.] Yantai Ctr Dis Control & Prevent, Yantai, Shandong, Peoples R China.
RP Juan, L (通讯作者)，Yantai Ctr Dis Control & Prevent, Yantai, Shandong, Peoples R China.
EM shj1022@163.com; suhj78@163.com
CR [Anonymous], WORLD J SURG ONCOL
   Antony S, 2004, J NATL MED ASSOC, V96, P1073
   Banwell P E, 2003, J Wound Care, V12, P22
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Fabian TS, 2000, AM SURGEON, V66, P1136
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   Morykwas M J, 1997, J South Orthop Assoc, V6, P279
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 12
TC 4
Z9 5
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD FEB
PY 2016
VL 42
IS 1
BP 87
EP 90
DI 10.1007/s00068-015-0509-9
PG 4
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA DD9RY
UT WOS:000370264500013
PM 26038028
DA 2026-07-24
ER
PT J
AU Walma, MS
   Burbach, JPM
   Verheijen, PM
   Pronk, A
   van Grevenstein, WMU
AF Walma, M. S.
   Burbach, J. P. M.
   Verheijen, P. M.
   Pronk, A.
   van Grevenstein, W. M. U.
TI Vacuum-assisted closure therapy for infected perineal wounds after
   abdominoperineal resection. A retrospective cohort study
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Rectal cancer; Abdominoperineal resection; Perineal wound infection; VAC
   therapy
ID TOTAL MESORECTAL EXCISION; PREOPERATIVE RADIOTHERAPY; RECTAL-CANCER;
   COMPLICATIONS; MULTICENTER; MANAGEMENT; MORBIDITY; COLLAGEN
AB Introduction: Perineal wound complications are a main problem after abdominoperineal resection (APR). There is little evidence concerning perineal wound management. This study describes and evaluates the role of vacuum-assisted closure (VAC) therapy in wound management strategies of perineal wound infections after APR.
   Methods: Patients undergoing APR for malignant disease between January 2007 and January 2013 were identified retrospectively. Data regarding occurrence and management of perineal wound complications were collected. Perineal wound infections were classified into minor or major complications and time to wound healing was measured. Time to wound healing was compared between patients receiving routine care or with additional VAC therapy.
   Results: Of 171 included patients, 76 (44.4%) had minor and 36 (21.1%) major perineal wound infections. Management of major infected perineal wounds consisted of drainage (n = 16), debridement (n = 4), drainage combined with debridement (n = 4), VAC therapy alone (n = 5), or VAC therapy combined with other treatments (n = 7). Median duration of perineal wound healing in major infected wounds was 141 days (range 17-739). Median time to wound healing was not different in patients treated with (172 days, range 23-368) or without VAC therapy (131 days, range 17-739).
   Discussion and conclusion: In this study, VAC therapy did not shorten time to wound healing. However, prospective studies are required to investigate the role of VAC therapy in management of infected perineal wounds after APR. Up to then, wound management will remain to be based on clinical perception and 'gut-feeling'. (c) 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.
C1 [Walma, M. S.; Burbach, J. P. M.; van Grevenstein, W. M. U.] Univ Med Ctr, Dept Surg, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
   [Verheijen, P. M.] Meander Med Ctr, Dept Surg, Maatweg 3, NL-3813 TZ Amersfoort, Netherlands.
   [Pronk, A.] Diakonessen Hosp, Dept Surg, Bosboomstr 1, NL-3582 KE Utrecht, Netherlands.
C3 Meander Medisch Centrum; Diakonessenhuis
RP Walma, MS (通讯作者)，Univ Med Ctr, Dept Surg, Postbus 85500, NL-3508 GA Utrecht, Netherlands.
EM m.s.walma@umcutrecht.com
OI Verheijen, Paul/0000-0003-2213-8310
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NR 40
TC 9
Z9 12
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD FEB
PY 2016
VL 26
BP 18
EP 24
DI 10.1016/j.ijsu.2015.12.009
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DE1GU
UT WOS:000370375900004
PM 26718610
DA 2026-07-24
ER
PT J
AU Firat, C
   Aytekin, AH
   Erbatur, S
AF Firat, Cemal
   Aytekin, Ahmet Hamdi
   Erbatur, Serkan
TI Management of Composite Tissue Defect of the Midfoot With a Free
   Anterolateral Thigh Flap and Iliac Bone Graft: A Case Report
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE ALT fasciocutaneous flap; bone reconstructive surgery; bone
   scintigraphy; vacuum-assisted closure
ID OPEN TIBIAL FRACTURES; VASCULARIZED FIBULAR GRAFTS; SOFT-TISSUE;
   LOWER-EXTREMITY; EXTERNAL FIXATION; RECONSTRUCTION; MUSCLE; EXPERIENCE;
   FOOT
AB Composite tissue defects of the midfoot with extensive bone and soft tissue loss represent a unique challenge because they can lead to primary amputation if not reconstructed. One should repair both the bone structure and the soft tissue to obtain satisfactory foot function for basic daily activities. In the present study, we report on a case in which we successfully reconstructed an extensive midfoot defect with iliac bone grafts for metatarsal reconstruction and an anterolateral thigh flap for soft tissue coverage. This technique is a safe, reliable, and functional method, offering single-stage reconstruction compared with other microsurgical techniques used for such defects. (C) 2016 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Firat, Cemal; Aytekin, Ahmet Hamdi] Inonu Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, TR-44280 Malatya, Turkey.
   [Erbatur, Serkan] Dicle Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Diyarbakir, Turkey.
C3 Inonu University; Dicle University
RP Aytekin, AH (通讯作者)，Inonu Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, TR-44280 Malatya, Turkey.
EM ahaytekin@gmail.com
RI Erbatur, Serkan/LZH-1943-2025; Fırat, Cemal/D-1292-2012
OI Fırat, Cemal/0000-0003-2051-6410
CR BEHRENS F, 1983, CLIN ORTHOP RELAT R, P111
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NR 27
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAR-APR
PY 2016
VL 55
IS 2
BP 263
EP 266
DI 10.1053/j.jfas.2014.06.021
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA DE5FV
UT WOS:000370657600011
PM 25128303
DA 2026-07-24
ER
PT J
AU Nolff, MC
   Meyer-Lindenberg, A
AF Nolff, M. C.
   Meyer-Lindenberg, A.
TI Negative Pressure Wound Therapy (NPWT) in small animal medicine.
   Mechanisms of action, applications and indications
SO TIERAERZTLICHE PRAXIS AUSGABE KLEINTIERE HEIMTIERE
LA German
DT Article
DE Open wound treatment; skin grafts; open abdomen; impaired wound healing
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; CLOSED INCISION
   MANAGEMENT; SUBATMOSPHERIC PRESSURE; RETROSPECTIVE EVALUATION;
   GRANULATION-TISSUE; SEPTIC PERITONITIS; ENHANCE; RECONSTRUCTION;
   INSTILLATION
AB The treatment of open wounds is a daily challenge in veterinary medicine. During the past years, a special treatment option, the Negative Pressure Wound Therapy (NPWT), has been developed. Usage of this therapy significantly increases the healing rate of open wounds as well as free skin grafts in small animals. This review describes the mechanisms of action, indications as well as the known complications associated with this therapy.
C1 [Nolff, M. C.; Meyer-Lindenberg, A.] Univ Munich, Zentrum Klin Tiermed, Chirurg & Gynakol Kleintierklin, Vet Str 13, D-80539 Munich, Germany.
C3 University of Munich
RP Nolff, MC (通讯作者)，Univ Munich, Zentrum Klin Tiermed, Chirurg & Gynakol Kleintierklin, Vet Str 13, D-80539 Munich, Germany.
EM m.nolff@Imu.de
RI Nolff, Mirja/W-6756-2019; Meyer-Lindenberg, Andrea/H-1076-2011
OI Nolff, Mirja/0000-0001-9317-7769; Meyer-Lindenberg,
   Andrea/0000-0001-6137-3773
CR Abramo F, 2008, AUST VET J, V86, P95, DOI 10.1111/j.1751-0813.2007.00243.x
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NR 89
TC 9
Z9 14
U1 1
U2 15
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 1434-1239
EI 2567-5842
J9 TIERAERZTL PRAX K H
JI Tierarztl. Prax. Ausg. Kleintiere Heimtiere
PY 2016
VL 44
IS 1
BP 26
EP 37
DI 10.15654/TPK-150957
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA DE5NO
UT WOS:000370677900003
PM 26830725
DA 2026-07-24
ER
PT J
AU Aldridge, B
   Ladd, AP
   Kepple, J
   Wingle, T
   Ring, C
   Kokoska, ER
AF Aldridge, Beau
   Ladd, Alan P.
   Kepple, Jacqueline
   Wingle, Teresa
   Ring, Christopher
   Kokoska, Evan R.
TI Negative pressure wound therapy for initial management of giant
   omphalocele
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Omphalocele; Wound VAC; Negative pressure wound therapy
AB BACKGROUND: Current treatment of giant omphalocele includes "paint and wait'' or placement of mesh or silo. These methods are associated with high complication rates. We propose negative pressure wound therapy as an alternative.
   METHODS: Patients born between 2009 and 2014 with giant omphalocele were included. Outcomes analyzed were duration of therapy, time to full enteral feeds, treatment related complications, wound surface area over time, type, and time to definitive closure.
   RESULTS: Eight patients were reviewed. The median duration of therapy was 68 days. Median time to full enteral feeds was 19 days. There were no treatment discontinuations or complications including sac ruptures, wound infections, or fistulas. Wound contraction stopped at 2 months or around 7 cm(2). All surviving patients underwent definitive closure.
   CONCLUSIONS: Negative pressure wound therapy is a safe and effective treatment for giant omphalocele that allows feeding, has a low complication rate, and is completed in 2 months. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Aldridge, Beau; Kepple, Jacqueline; Wingle, Teresa; Ring, Christopher; Kokoska, Evan R.] Peyton Manning Childrens Hosp, Dept Pediat Surg, 2001 W 86th St, Indianapolis, IN 46260 USA.
   [Ladd, Alan P.] Indiana Univ, Sch Med, Dept Surg, Riley Hosp Children, Indianapolis, IN 46202 USA.
C3 Indiana University Health; James Whitcomb Riley Hospital Children;
   Indiana University System; Indiana University Indianapolis
RP Kokoska, ER (通讯作者)，Peyton Manning Childrens Hosp, Dept Pediat Surg, 2001 W 86th St, Indianapolis, IN 46260 USA.
EM erkokosk@stvincent.org
CR Binet A, 2013, J PLAST RECONSTR AES, V66, pE373, DOI 10.1016/j.bjps.2013.05.010
   Canfield MA, 2006, BIRTH DEFECTS RES A, V76, P747, DOI 10.1002/bdra.20294
   Coran A, 2012, PEDIAT SURG, P973
   Elin SH, 2012, J PEDIATR SURG, V47, P494
   Kilbride KE, 2006, J PEDIATR SURG, V41, P212, DOI 10.1016/j.jpedsurg.2005.10.003
   Mitanchez D, 2010, J PEDIATR SURG, V45, P1727, DOI 10.1016/j.jpedsurg.2010.04.011
   van Eijck FC, 2011, J PEDIATR SURG, V46, P482, DOI 10.1016/j.jpedsurg.2010.08.050
NR 7
TC 20
Z9 25
U1 0
U2 3
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAR
PY 2016
VL 211
IS 3
BP 605
EP 608
DI 10.1016/j.amjsurg.2015.11.009
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DE5YR
UT WOS:000370709900041
PM 26778271
DA 2026-07-24
ER
PT J
AU Cantero, R
   Rubio-Perez, I
   Leon, M
   Alvarez, M
   Diaz, B
   Herrera, A
   Diaz-Dominguez, J
   Rodriguez-Montes, JA
AF Cantero, Ramon
   Rubio-Perez, Ines
   Leon, Miguel
   Alvarez, Mario
   Diaz, Beatriz
   Herrera, Ana
   Diaz-Dominguez, Joaquin
   Rodriguez-Montes, Jose Antonio
TI Negative-Pressure Therapy to Reduce the Risk of Wound Infection
   Following Diverting Loop Ileostomy Reversal: An Initial Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE surgical infections; negative-pressure therapy; Prevena; wound care;
   ileostomy closure wounds
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; INCISION
   MANAGEMENT-SYSTEM; PREVENTION; SURGERY; STOMA; EXPERIENCE
AB OBJECTIVE:
   To evaluate if the application of a negative-pressure therapy system (Prevena Incision Management System, Kinetics Concepts Inc, [KCI] an Acelity Company, San Antonio, Texas) on ileostomy-closure surgical wounds would reduce surgical site infections (SSIs) in comparison with conventional closure and dressing.
   DESIGN:
   Prospective interventional pilot study.
   SETTING:
   La Paz University Hospital, tertiary care academic hospital in Madrid, Spain.
   PATIENTS:
   The Prevena device was applied on the wounds of 17 consecutive patients undergoing ileostomy reversal. Control subjects were 43 patients undergoing the same procedure, in which conventional dressings were used for the wound.
   INTERVENTION:
   The device was applied on the wound immediately after surgery (under sterile conditions) and maintained for 5 to 7 days. Patients were evaluated daily, and on the seventh postoperative day, the device was removed and wounds carefully inspected. Another evaluation was performed a month after the surgical intervention in the outpatient clinic.
   MAIN OUTCOME MEASURE:
   The primary end point of the study was the detection of SSI (defined according to the Centers for Disease Control and Prevention definitions). Other intervention-related complications were also registered.
   MAIN RESULTS:
   There were no significant differences in demographic variables between groups. In the control group, 9 patients (21%) presented SSI, with statistical significance (P < .038) when compared with the intervention group (0%). There were no complications associated with the application of the Prevena device. Other complications (for example, ileus or obstruction) occurred in 30% of patients.
   CONCLUSIONS:
   The negative-pressure Prevena System was safe and easy to use and may prevent SSIs in dirty wounds, such as those from ileostomy closure.
C1 [Cantero, Ramon; Rubio-Perez, Ines; Leon, Miguel; Alvarez, Mario; Diaz, Beatriz; Herrera, Ana; Diaz-Dominguez, Joaquin; Rodriguez-Montes, Jose Antonio] La Paz Univ Hosp, Gen & Digest Surg Dept, Madrid, Spain.
C3 Hospital Universitario La Paz
RP Cantero, R (通讯作者)，La Paz Univ Hosp, Gen & Digest Surg Dept, Madrid, Spain.
RI Cantero, Ramon/JTV-4751-2023
OI Rubio-Perez, Ines/0000-0002-3960-6865
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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   Bovill E, 2008, INT WOUND J, V5, P511, DOI 10.1111/j.1742-481X.2008.00437.x
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   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   Dusch N, 2013, COLORECTAL DIS, V15, P1033, DOI 10.1111/codi.12211
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   Olona C, 2014, ADV SKIN WOUND CARE, V27, P77, DOI 10.1097/01.ASW.0000442873.48590.b5
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NR 24
TC 30
Z9 35
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAR
PY 2016
VL 29
IS 3
BP 114
EP 118
DI 10.1097/01.ASW.0000480458.60005.34
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA DE6EH
UT WOS:000370726000001
PM 26866867
OA hybrid
DA 2026-07-24
ER
PT J
AU Laje, P
   Hedrick, HL
   Flake, AW
   Adzick, NS
   Peranteau, WH
AF Laje, Pablo
   Hedrick, Holly L.
   Flake, Alan W.
   Adzick, N. Scott
   Peranteau, William H.
TI Delayed abdominal closure after congenital diaphragmatic hernia repair
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 62nd Annual Meeting of the British-Association-of-Paediatric-Surgeons
CY JUL 22-24, 2015
CL Cardiff, WALES
SP British Assoc Paediat Surg
DE Congenital diaphragmatic hernia; Extracorporeal membrane oxygenation;
   Delayed abdominal closure; Open abdomen
ID WALL CLOSURE
AB Purpose: We present our experience with CDH patients who required delayed abdominal closure following CDH repair.
   Methods: A retrospective review of all CDH repairs from 2004 to 2014 was performed.
   Results: 233 patients underwent CDH repair, of which 21 required delayed abdominal closure defined as the inability to close the abdominal fascia at the time of CDH repair. The incidence of delayed closure was higher in those undergoing CDH repair on ECMO vs. not on ECMO(40% [17/43] vs. 2% [4/190]; P < 0.001). The abdominal wound was temporarily covered by skin only (n = 2), skin + prosthetic mesh sutured to the fascia (n = 3), preformed silo (n = 9), or vacuum assisted closure (VAC (R)) device (n = 7). The mean time to fascial closure was 14.5+/-7 and 6+/-3 days for patients repaired on ECMO and not on ECMO, respectively. In patients repaired on ECMO, the "primary closure" and "delayed closure" groups were not different in prenatal predictors (liver up, lung-to-head ratio [LHR]), total days on ECMO, ECMO days prior to CDH repair, and survival. In patients repaired on ECMO, the "delayed closure" group had a significantly higher requirement for blood transfusions compared to the "primary closure" group (mean 87+/-35 vs. 62+/-27 ml of packed RBCs per ECMO day; P=0.01).
   Conclusion: Delayed abdominal closure was required in 40% of CDH repairs done on ECMO but was rarely required in CDH repairs performed off ECMO. Although associated with an increased need for blood transfusions, delayed closure following CDH repair on ECMO was not associated with increased mortality. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Laje, Pablo; Hedrick, Holly L.; Flake, Alan W.; Adzick, N. Scott; Peranteau, William H.] Childrens Hosp Philadelphia, Div Gen Thorac & Fetal Surg, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of
   Philadelphia
RP Peranteau, WH (通讯作者)，Childrens Hosp Philadelphia, 34th St & Civ Ctr Blvd,Wood Bldg,Off 5100, Philadelphia, PA 19104 USA.
EM peranteauw@email.chop.edu
CR Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Bebbington M, 2014, ULTRASOUND OBST GYN, V43, P670, DOI 10.1002/uog.13271
   Desai AA, 2015, SEMIN PEDIATR SURG, V24, P17, DOI 10.1053/j.sempedsurg.2014.11.004
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   Erik G, 2010, J PEDIATR SURG, V45, P1324
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   Rana AR, 2008, J PEDIATR SURG, V43, P788, DOI 10.1016/j.jpedsurg.2007.12.011
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NR 13
TC 19
Z9 22
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD FEB
PY 2016
VL 51
IS 2
BP 240
EP 243
DI 10.1016/j.jpedsurg.2015.10.069
PG 4
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Surgery
GA DE7JA
UT WOS:000370810800010
PM 26653950
DA 2026-07-24
ER
PT J
AU Crew, JR
   Thibodeaux, KT
   Speyrer, MS
   Gauto, AR
   Shiau, T
   Pang, LLA
   Bley, K
   Debabov, D
AF Crew, John R.
   Thibodeaux, Kerry T.
   Speyrer, Marcus S.
   Gauto, Anibal R.
   Shiau, Timothy
   Pang, Liliana
   Bley, Keith
   Debabov, Dmitri
TI Flow-through Instillation of Hypochlorous Acid in the Treatment of
   Necrotizing Fasciitis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE necrotizing fasciitis; negative pressure; tissue repair
ID PRESSURE WOUND THERAPY; MANAGEMENT; DIAGNOSIS; SUPERANTIGENS
AB Introduction. Necrotizing fasciitis (NF) is a rare and rapidly progressing bacterial infection of soft tissues. Bacterial toxins cause local tissue damage and necrosis, as well as blunt immune system responses. A self-propagating cycle of bacterial invasion, toxin release and tissue destruction can continue until substantial amounts of tissue become necrotic. Neutralization of bacterial toxins should improve the results. Materials and Methods. Pure hypochlorous acid (HOCI) (0.01% w/v) with no sodium hypochlorite impurity in saline pH 4-5, which was recently shown to both eradicate bacteria and neutralize bacterial toxins in vitro, was administered via flow through instillation to 6 patients with NF 4-6 times daily as needed. Utilizing a vacuum -assisted closure, 5-10 mL of pure 0.01% HOCI with no sodium hypochlorite impurity was instilled and removed frequently to irrigate the wounds. Results. Of the 6 patients, no deaths or limb amputations occurred. All infected areas healed completely without major complications. Conclusion. The toxicity and immune dysfunction caused by bacterial toxins and toxins released from damaged cells may be mitigated by flow-through instillation with saline containing pure 0.01% HOCI with no sodium hypochlorite impurity. Randomized controlled clinical trial research of this relatively simple and inexpensive instillation protocol is suggested for identified cases of NE.
C1 [Crew, John R.] Seton Med Ctr, Wound Care Ctr, 1900 Sullivan Ave, Daly City, CA 94015 USA.
   [Thibodeaux, Kerry T.; Speyrer, Marcus S.] Opelousas Gen Hlth Syst, Wound Treatment Ctr LLC, Opelousas, LA USA.
   [Gauto, Anibal R.] Eisenhower Med Ctr, Rancho Mirage, CA USA.
   [Shiau, Timothy; Pang, Liliana; Bley, Keith; Debabov, Dmitri] NovaBay Pharmaceut Inc, Emeryville, CA USA.
RP Crew, JR (通讯作者)，Seton Med Ctr, Wound Care Ctr, 1900 Sullivan Ave, Daly City, CA 94015 USA.
EM jcrewmd@att.net
CR Baharestani MM, 2008, OSTOMY WOUND MANAG, V54, P44
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   Wang L, 2007, J Burns Wounds, V6, pe5
NR 26
TC 12
Z9 13
U1 0
U2 9
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2016
VL 28
IS 2
BP 40
EP 47
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DE7QM
UT WOS:000370831800005
PM 26891136
DA 2026-07-24
ER
PT J
AU de Souza, SC
   Briglia, CH
   Cavazzani, RM
AF de Souza, Sandro Cilindro
   Briglia, Carlos Henrique
   Cavazzani, Reinaldo Miranda
TI A Simplified Vacuum Dressing System
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE wound healing; negative pressure wound therapy; vacuum-assisted closure;
   plastic surgery
ID WOUND THERAPY SYSTEM; ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE;
   MANAGEMENT; STATE
AB Negative pressure wound therapy (NPWT) may not necessarily require sophisticated equipment. In settings with limited medical resources, simplified vacuum dressings have been considered an effective alternative to the gold-standard vacuum-assisted closure system. The aim of this study was to evaluate the performance of a simplified vacuum dressing system in the treatment of complex wounds. Materials and Methods. This was a prospective study in which difficult-to-manage wounds were treated using a simplified vacuum dressing system. Thirty-nine patients with a total of 51 wounds were treated. The main complications were pain (15.7%), bleeding (9.6%), and extremity edema (5.2%). After NPWT, the wounds were closed by skin grafting or with a skin flap in 71.8% of patients. Results. The results of NPWT were considered satisfactory in 87.2% of cases. The use of a simplified vacuum dressing system provided satisfactory results in the treatment of complex wounds in the studied population. Conclusion. The system proved easy to use, had a low complication rate and excellent cost-effectiveness, and it may be considered as an effective alternative to the gold-standard vacuum-assisted closure system for patients requiring prolonged hospitalization due to the presence of extensive wounds that cannot be treated at home.
C1 [de Souza, Sandro Cilindro; Briglia, Carlos Henrique] Bahia State Gen Hosp, Salvador, BA, Brazil.
RP de Souza, SC (通讯作者)，Rua Conselheiro Correia Menezes 182, BR-40295030 Salvador, BA, Brazil.
EM sandrocilin@gmail.com
CR [Anonymous], REV BRAS CIR PLAST
   [Anonymous], 2003, ASERNIP-S Report No.37
   [Anonymous], REV BRAS CIR PLAST
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NR 29
TC 3
Z9 5
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2016
VL 28
IS 2
BP 48
EP 56
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DE7QM
UT WOS:000370831800006
PM 26891137
DA 2026-07-24
ER
PT J
AU Akil, A
   Schnorr, P
   Wiebe, K
AF Akil, A.
   Schnorr, P.
   Wiebe, K.
TI Strategies for the treatment of postoperative sternal infections
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE sternal infection; sternal osteomyelitis; VAC (R) therapy; sternal
   resection; muscle flap
ID OPEN-HEART-SURGERY; CHEST-WALL RECONSTRUCTION; VACUUM-ASSISTED CLOSURE;
   MEDIAN STERNOTOMY; RISK-FACTORS; WOUND INFECTIONS; MEDIASTINITIS;
   COMPLICATIONS; RESECTION; DEHISCENCE
AB Postoperative sternal infections are associated with significant morbidity and mortality. An incidence of up to 8% has to be expected. Typically, a highly inflammatory acute infection with a marked soft tissue component is observed. However, the infection may also be present as a less symptomatic reaction and localised chronic osteomyelitis with fistula formation. The treatment strategy for a deep sternal wound infection consists of several steps. A radical debridement of the wound requires the opening of all abscesses, the resection of non-vital bone and the removal of all infected allomaterial. This is followed by a period of VAC therapy ( Vacuum-Assisted Closure Therapy) for infection treatment and conditioning of the wound. Secondary closure of the wound may be planned only after the infection is completely controlled. The sternum is stabilised by osteosynthesis. Sternal defects are covered. In most cases adequate soft tissue coverage is achieved by mobilisation of both pectoral muscles together with the precostal soft tissues. Following resection of the sternum, the reconstruction of the thoracic wall requires the implantation of material for stabilisation as well as soft tissue coverage. For complicated or large defects various muscle flaps and the omentum majus have been advocated. The latissimus dorsi muscle with skin is the muscle flap most frequently used.
C1 [Akil, A.; Schnorr, P.; Wiebe, K.] Univ Klinikum Munster, Sekt Thoraxchirurg, Herz & Thoraxchirurg, Albert Schweitzer Campus 1, D-48419 Munster, Germany.
C3 University of Munster
RP Wiebe, K (通讯作者)，Univ Klinikum Munster, Sekt Thoraxchirurg, Herz & Thoraxchirurg, Albert Schweitzer Campus 1, D-48419 Munster, Germany.
EM karsten.wiebe@ukmuenster.de
RI Schnorr, Philipp/GOE-5551-2022
OI Schnorr, Philipp/0000-0002-8853-9371; Akil, Ali/0000-0002-3748-1181
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NR 50
TC 1
Z9 6
U1 0
U2 6
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD FEB
PY 2016
VL 141
IS 1
BP 93
EP 101
DI 10.1055/s-0035-1558097
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DF1JH
UT WOS:000371095200023
PM 26492536
DA 2026-07-24
ER
PT J
AU Chan, M
   Yusuf, E
   Giulieri, S
   Perrottet, N
   Von Segesser, L
   Borens, O
   Trampuz, A
AF Chan, Monica
   Yusuf, Erlangga
   Giulieri, Stefano
   Perrottet, Nancy
   Von Segesser, Ludwig
   Borens, Olivier
   Trampuz, Andrej
TI A retrospective study of deep sternal wound infections: clinical and
   microbiological characteristics, treatment, and risk factors for
   complications
SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
LA English
DT Article
DE Post-operative mediastinitis; Sternal osteomyelitis; Deep sternal wound
   infection; Sternotomy; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; NEGATIVE-PRESSURE;
   POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY; POSTOPERATIVE
   MEDIASTINITIS; CLOSED-DRAINAGE; BACTERIAL LOAD; THERAPY; TRANSPOSITION
AB Deep sternal wound infection (DSWI) is a feared complication following cardiac surgery. This study describes clinical, microbiological, and treatment outcomes of DSWI and determines risk factors for complications. Of 55 patients with DSWI, 66% were male and mean age was 68.2 years. Initial sternotomy was for coronary artery bypass graft in 49% of patients. Sternal debridement at mean 25.4 +/- 18.3 days showed monomicrobial (94%), mainly Gram-positive infection. Secondary sternal wound infection (SSWI) occurred in 31% of patients, was mostly polymicrobial (71%), and was predominantly due to Gram-negative bacilli. Risk factors for SSWI were at least 1 revision surgery (odds ratio [OR] 4.8 [95% confidence interval {CI} 1.0-22.4], P = 0.047), sternal closure by muscle flap (OR 4.6[1.3-16.8], P = 0.02), delayed sternal closure (mean 27 versus 14 days, P = 0.03), and use of vacuum-assisted closure device (100% versus 58%, P = 0.008). Hospital stay was significantly longer in patients with SSWI (69 days versus 48 days, P = 0.04). (C) 2016 Elsevier Inc. All rights reserved.
C1 [Chan, Monica] Tan Tock Seng Hosp, Dept Infect Dis, Singapore, Singapore.
   [Yusuf, Erlangga; Perrottet, Nancy; Borens, Olivier] Univ Lausanne Hosp, Sept Surg Unit, Lausanne, Switzerland.
   [Yusuf, Erlangga; Giulieri, Stefano; Trampuz, Andrej] Univ Lausanne Hosp, Infect Dis Serv, Lausanne, Switzerland.
   [Perrottet, Nancy] Univ Lausanne Hosp, Dept Pharm, Lausanne, Switzerland.
   [Von Segesser, Ludwig] Univ Lausanne Hosp, Cardiovasc Surg, Lausanne, Switzerland.
   [Yusuf, Erlangga] Univ Ziekenhuis Brussel, Dept Med Microbiol & Infect Control, Brussels, Belgium.
   [Trampuz, Andrej] Free & Humboldt Univ Berlin, Charite Univ Med, Ctr Musculoskeletal Surg, Berlin, Germany.
C3 Tan Tock Seng Hospital; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); Vrije Universiteit Brussel; University
   Hospital Brussels; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin
RP Yusuf, E (通讯作者)，Univ Lausanne Hosp, Sept Surg Unit, Lausanne, Switzerland.; Yusuf, E (通讯作者)，Univ Lausanne Hosp, Infect Dis Serv, Lausanne, Switzerland.
EM angga.yusuf@gmail.com
RI Yusuf, Erlangga/H-5166-2019; Giulieri, Stefano/IUO-3253-2023
OI Yusuf, Erlangga/0000-0003-4779-2191; Giulieri,
   Stefano/0000-0001-5366-1943
FU Healthcare Manpower Development Plan, Ministry of Health, Singapore
FX This study was supported by an educational grant to Monica Chan by the
   Healthcare Manpower Development Plan, Ministry of Health, Singapore.
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NR 42
TC 45
Z9 57
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0732-8893
EI 1879-0070
J9 DIAGN MICR INFEC DIS
JI Diagn. Microbiol. Infect. Dis.
PD MAR
PY 2016
VL 84
IS 3
BP 261
EP 265
DI 10.1016/j.diagmicrobio.2015.11.011
PG 5
WC Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Microbiology
GA DF2PP
UT WOS:000371186500022
PM 26707065
DA 2026-07-24
ER
PT J
AU Kim, SW
   Youn, DG
   Hwang, KT
   Kim, JT
   Kim, YH
AF Kim, Sang Wha
   Youn, Dong Geun
   Hwang, Kyu Tae
   Kim, Jeong Tae
   Kim, Youn Hwan
TI RECONSTRUCTION OF SEVERELY INFECTED GLUTEAL OSTEORADIONECROSIS USING
   NEGATIVE-PRESSURE WOUND THERAPY AND LATISSIMUS DORSI MUSCULOCUTANEOUS
   FLAPS
SO MICROSURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BACTERIAL INOCULATION; PERFORATOR FLAP; NORMAL
   TISSUE; SUPERIOR; SALVAGE; MANAGEMENT; RADIATION; DEFECT
AB Radiotherapy is mandatory for aggressive cancer treatment. Unfortunately, the high-energy radiation used can lead to severe osteoradionecrosis. Radical debridement of devitalized bone and soft tissue coupled with reconstruction using well-vascularized tissues is the accepted treatment for this condition. However, osteoradionecrosis cannot be controlled easily or rapidly. The aim of this study was to present the results of the use of serial negative-pressure wound therapy (NPWT) in combination with a latissimus dorsi myocutaneous flap for treatment of gluteal osteoradionecrosis in a consecutive series of patients. Between January 2003 and December 2012, nine patients underwent reconstruction using serial NPWT and latissimus dorsi myocutaneous flaps. We applied negative-pressure dressings for at least 8 weeks. Final reconstruction was performed after the infection was controlled. The superior gluteal artery and vein were used as recipient vessels in all the cases. The mean interval between operation and radiation therapy was 28.3 +/- 8.3 years, and the mean number of debridement performed was 6.3 +/- 1. NPWT dressings were applied for 8-12 weeks (mean, 9.3 +/- 2 weeks). The defects ranged in size from 14 x 8 cm to 18 x 15 cm. The flap size ranged from 15 x 10 cm to 18 x 15 cm. All flaps survived uneventfully except in one patient who experienced chronic seroma and wound dehiscence. There were no recurrences of osteomyelitis during the follow-up periods (mean, 14 +/- 6.1 months). Based on the results obtained from this consecutive series of patients, we suggest that this methodology may provide an alternative approach for the treatment of severe osteoradionecrosis of the gluteal region. (C) 2015 Wiley Periodicals, Inc.
C1 [Kim, Sang Wha] Catholic Univ Korea, Dept Plast & Reconstruct Surg, Seoul, South Korea.
   [Youn, Dong Geun; Kim, Jeong Tae; Kim, Youn Hwan] Hanyang Univ, Coll Med, Dept Plast & Reconstruct Surg, Seoul 133791, South Korea.
   [Hwang, Kyu Tae] Hanyang Univ, Dept Orthoped Surg, Coll Med, Seoul 133791, South Korea.
C3 Catholic University of Korea; Hanyang University; Hanyang University
RP Kim, YH (通讯作者)，Hanyang Univ, Sch Med, Dept Plast & Reconstruct Surg, 17 Haengdang Dong, Seoul 133792, South Korea.
EM younhwank@daum.net
RI Hwang, Kyu/R-7249-2016
OI Kim, Sang Wha/0000-0003-0430-3458
FU Hanyang University [HY-2013]
FX Grant sponsor: Hanyang University; Grant number: HY-2013.
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NR 30
TC 8
Z9 9
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD JAN
PY 2016
VL 36
IS 1
BP 29
EP 36
DI 10.1002/micr.22370
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DF6SM
UT WOS:000371486700003
PM 25641653
OA Bronze
DA 2026-07-24
ER
PT J
AU Wollina, U
   Langner, D
   Heinig, B
   Schönlebe, J
   Nowak, A
AF Wollina, Uwe
   Langner, Dana
   Heinig, Birgit
   Schoenlebe, Jacqueline
   Nowak, Andreas
TI Complicated Skin and Skin Structure Infection After Erysipelas: Urgent
   Need for Antibiosis and Surgery
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE erysipelas; complicated skin and skin structure infection; panniculitis;
   vacuum-assisted closure therapy; surgery
ID SOFT-TISSUE INFECTIONS; RISK-FACTORS; CELLULITIS
AB Erysipelas are common soft tissue infections responding to first-line antibiosis. Because of factors of related to responsible bacteria and host, complications can occur that need extensive surgery in addition to intensified drug therapy. We report on a 65-year-old woman with leg ulcer who developed an absceding and necrotizing panniculitis of the affected leg complicating erysipelas. Escherichia coli and Pseudomonas aeruginosa were identified. Debridement and surgical removal of inflamed subcutaneous adipose tissue was decisive to interrupt the process. Wound bed preparation was realized by vacuum-assisted closure. Final wound closure was done by split-skin mesh graft. Complicated skin and skin structure infections need a combined approach of intensified antibiosis and surgery to save life.
C1 [Wollina, Uwe; Langner, Dana; Heinig, Birgit; Schoenlebe, Jacqueline; Nowak, Andreas] Acad Teaching Hosp Dresden Friedrichstadt, Dresden, Germany.
C3 Technische Universitat Dresden; Municipal Hospital Dresden
RP Wollina, U (通讯作者)，Acad Teaching Hosp Dresden Friedrichstadt, Dept Dermatol & Allergol, Friedrichstr 41, D-01067 Dresden, Germany.
EM wollina-uw@khdf.de
RI ; Wollina, Uwe/AAJ-9644-2020
OI Nowak, Aneas/0000-0003-4105-4358; Wollina, Uwe/0000-0001-5933-2913
CR Bläckberg A, 2015, BMC INFECT DIS, V15, DOI 10.1186/s12879-015-1134-2
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NR 14
TC 2
Z9 5
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2016
VL 15
IS 1
BP 68
EP 70
DI 10.1177/1534734616628372
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DF9QY
UT WOS:000371697400012
PM 26933116
DA 2026-07-24
ER
PT J
AU Sun, SY
   Wang, C
   Chen, DW
   Cen, SQ
   Lv, XJ
   Wen, XR
   Liu, M
   Lu, WS
   Zhao, JC
   Ran, XW
AF Sun, Shuyao
   Wang, Chun
   Chen, Dawei
   Cen, Shiqiang
   Lv, Xiaoju
   Wen, Xiaorong
   Liu, Min
   Lu, Wusheng
   Zhao, Jichun
   Ran, Xingwu
TI Combating Superbug Without Antibiotic on a Postamputation Wound in a
   Patient With Diabetic Foot
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE autologous platelet-rich gel; diabetic foot; multidrug-resistant
   bacterial infection; negative pressure wound therapy
ID RICH PLASMA GEL; NEGATIVE-PRESSURE; LEUKOCYTE; THERAPY; ULCERS
AB Diabetic foot is a kind of limb- and life-threatening complication that is difficult to treat with conventional therapy, especially when accompanied with peripheral arterial insufficiency and severe infection. We present a diabetic patient with a postamputation wound infected by multidrug-resistant Acinetobacter baumannii/haemolyticus, which was resistant to almost all antibiotics. As the clinical response to antimicrobial therapy was poor, antibiotic was discontinued. Autologous platelet-rich gel with anticoagulation, negative pressure wound therapy, and improvement of microcirculation were used successfully to eradicate infection of the superbug and achieve final wound closure.
C1 [Sun, Shuyao; Wang, Chun; Chen, Dawei; Cen, Shiqiang; Lv, Xiaoju; Wen, Xiaorong; Liu, Min; Lu, Wusheng; Zhao, Jichun; Ran, Xingwu] Sichuan Univ, West China Hosp, Chengdu 610064, Sichuan, Peoples R China.
C3 Sichuan University
RP Ran, XW (通讯作者)，Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, Diabet Foot Care Ctr, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China.
EM ranxingwu@163.com
RI Chen, Dawei/V-4296-2019; Zhao, Ji-Chun/GWM-8456-2022
FU National Natural Science Foundation of China [81170776]; Science and
   Technology Bureau of Sichuan Province, China [2009sz0153]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported in part by Grant 81170776 from the National Natural
   Science Foundation of China and Grant 2009sz0153 from the Science and
   Technology Bureau of Sichuan Province, China.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 17
TC 11
Z9 15
U1 1
U2 27
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2016
VL 15
IS 1
BP 74
EP 77
DI 10.1177/1534734615595736
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DF9QY
UT WOS:000371697400014
PM 26238676
DA 2026-07-24
ER
PT J
AU Lance, S
   Harrison, L
   Orbay, H
   Boudreault, D
   Pereira, G
   Sahar, D
AF Lance, Samuel
   Harrison, Lindsey
   Orbay, Hakan
   Boudreault, David
   Pereira, Gavin
   Sahar, David
TI Assessing safety of negative-pressure wound therapy over pedicled muscle
   flaps: A retrospective review of gastrocnemius muscle flap
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Negative pressure wound therapy; Vacuum-assisted closure; Gastrocnemius
   pedicled muscle flap; Split thickness skin graft
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY; SKIN-GRAFTS; BLOOD-FLOW
AB The use of negative-pressure wound therapy (NPWT) for management of open wounds and immobilization of split-thickness skin grafts (STSGs) over wounds has been well described. However, there is a concern for potential compromise of flap viability when NPWT is used for skin grafts over pedicled muscle flaps. We have used NPWT to immobilize STSGs in eight patients who underwent a pedicled gastrocnemius muscle flap operation in our department. We applied a negative pressure of -75 mmHg on the muscle flaps for 5 days postoperatively. All wounds healed successfully, with a 97.5 +/- 5.5% mean STSG uptake. No flap necrosis was observed. In our series, the use of NPWT for fixation of STSGs over pedicled gastrocnemius muscle flap was effective and had no negative impact on flap viability. Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.
C1 [Lance, Samuel; Harrison, Lindsey; Orbay, Hakan; Boudreault, David; Sahar, David] Univ Calif Davis, Div Plast Surg, Dept Surg, Davis, CA 95616 USA.
   [Pereira, Gavin] Univ Calif Davis, Dept Orthoped Surg, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis
RP Sahar, D (通讯作者)，Univ Calif Davis, Med Ctr, Dept Surg, Div Plast Surg, 2221 Stockton Blvd,Suite 2123, Sacramento, CA 95817 USA.
EM desahar@ucdavis.edu
OI Harrison, Lindsey/0000-0003-0422-2893
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Petzina R, 2006, EUR J CARDIO-THORAC, V30, P85, DOI 10.1016/j.ejcts.2006.04.009
   Reddy Vikram, 2008, Plast Reconstr Surg, V121, P1, DOI 10.1097/01.prs.0000305928.98611.87
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NR 19
TC 10
Z9 14
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD APR
PY 2016
VL 69
IS 4
BP 519
EP 523
DI 10.1016/j.bjps.2015.11.010
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DG0YN
UT WOS:000371792200017
PM 26732293
DA 2026-07-24
ER
PT J
AU Verbelen, J
   Hoeksema, H
   Pirayesh, A
   Van Landuyt, K
   Monstrey, S
AF Verbelen, Jozef
   Hoeksema, Henk
   Pirayesh, Ali
   Van Landuyt, Koenraad
   Monstrey, Stan
TI Exposed tibial bone after burns: Flap reconstruction versus dermal
   substitute
SO BURNS
LA English
DT Article
DE Exposed tibia; Flap surgery; Flap reconstruction; Dermal substitute;
   Glyaderm; Negative pressure wound therapy; Full thickness burn
ID HEPARIN-INDUCED THROMBOCYTOPENIA; VACUUM-ASSISTED CLOSURE; SOFT-TISSUE
   RECONSTRUCTION; NEGATIVE-PRESSURE THERAPY; LOWER-EXTREMITY; ARTIFICIAL
   DERMIS; SUBATMOSPHERIC PRESSURE; PLASTIC-SURGERY; MANAGEMENT; FAILURE
AB A 44 years old male patient had suffered extensive 3rd degree burns on both legs, undergoing thorough surgical debridement, resulting in both tibias being exposed.
   Approximately 5 months after the incident he was referred to the Department of Plastic and Reconstructive Surgery of the University Hospital Gent, Belgium, to undergo flap reconstruction.
   Free flap surgery was performed twice on both lower legs but failed on all four occasions.
   In between flap surgery, a dermal substitute (Integra (R)) was applied, attempting to cover the exposed tibias with a layer of soft tissue, but also without success.
   In order to promote the development of granulation tissue over the exposed bone, small holes were drilled in both tibias with removal of the outer layer of the anterior cortex causing the bone to bleed and subsequently negative pressure wound therapy (NPWT) was applied.
   The limited granulation tissue resulting from this procedure was then covered with a dermal substitute (Glyaderm (R)), consisting of acellular human dermis with an average thickness of 0.25 mm.
   This dermal substitute was combined with a NPWT-dressing, and then served as an extracellular matrix (ECM), guiding the distribution of granulation tissue over the remaining areas of exposed tibial bone.
   Four days after initial application of Glyaderm (R) combined with NPWT both tibias were almost completely covered with a thin coating of soft tissue.
   In order to increase the thickness of this soft tissue cover two additional layers of Glyaderm (R) were applied at intervals of approximately 1 week. One week after the last Glyaderm (R) application both wounds were autografted.
   The combination of an acellular dermal substitute (Glyaderm (R)) with negative pressure wound therapy and skin grafting proved to be an efficient technique to cover a wider area of exposed tibial bone in a patient who was not a candidate for free flap surgery. An overview is also provided of newer and simpler techniques for coverage of exposed bone that could question the universal plastic surgery paradigm that flap surgery is the only way to cover these defects. (C) 2015 Elsevier Ltd and ISBI. All rights reserved.
C1 [Verbelen, Jozef; Hoeksema, Henk; Van Landuyt, Koenraad; Monstrey, Stan] Ghent Univ Hosp, Burn Ctr, Dept Plast & Reconstruct Surg, B-9000 Ghent, Belgium.
   [Pirayesh, Ali] Plast Surg, Amsterdam, Netherlands.
C3 Ghent University; Ghent University Hospital
RP Monstrey, S (通讯作者)，Ghent Univ Hosp, Burn Ctr, Dept Plast Surg, B-9000 Ghent, Belgium.
EM Stan.Monstrey@UGent.be
OI Hoeksema, Henik/0000-0003-3160-4539
CR [Anonymous], 2010, AC MATR TREATM WOUND
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NR 51
TC 28
Z9 32
U1 0
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAR
PY 2016
VL 42
IS 2
BP E31
EP E37
DI 10.1016/j.burns.2015.08.013
PG 7
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA DG6FW
UT WOS:000372179600005
PM 26376411
DA 2026-07-24
ER
PT J
AU Fischer, S
   Wall, J
   Pomahac, B
   Riviello, R
   Halvorson, EG
AF Fischer, Sebastian
   Wall, Jennifer
   Pomahac, Bohdan
   Riviello, Robert
   Halvorson, Eric G.
TI Extra-large negative pressure wound therapy dressings for burns -
   Initial experience with technique, fluid management, and outcomes
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy; Fluid resuscitation; Burn wound; Vacuum
   assisted closure device
ID ACUTE-RENAL-FAILURE; THICKNESS SKIN-GRAFTS; AREA IF HEIGHT; INDUCED
   HYPOPROTEINEMIA; THERMAL-INJURY; RESUSCITATION; DEPTH; CARE; FORMULA;
   WEIGHT
AB Objective: The use of negative-pressure-wound-therapy (NPWT) is associated with improved outcomes in smaller burns. We report our experience using extra-large (XL) NPWT dressings to treat >= 15% total body surface area (TBSA) burned and describe our technique and early outcomes. We also provide NPWT exudate volume for predictive fluid resuscitation in these critically ill patients.
   Methods: We retrospectively reviewed patients treated with XL-NPWT from 2012 to 2014. Following excision/grafting, graft and donor sites were sealed with a layered NPWT dressing. We documented wound size, dressing size, NPWT outputs, graft take, wound infections, and length of stay (LOS). Mean NPWT exudate volume per %TBSA per day was calculated.
   Results: Twelve burn patients (mean TBSA burned 30%, range 15-60%) were treated with XL-NPWT (dressing TBSA burned and skin graft donor sites range 17-44%). Average graft take was 97%. No wound infections occurred. Two patients had burns >= 50% TBSA and their LOS was reduced compared to ABA averages. XL-NPWT outputs peaked at day 1 after grafting followed by a steady decline until dressings were removed. Average XL-NPWT dressing output during the first 5 days was 101 +/- 66 mL/%BSA covered per day. 2 patients developed acute kidney injury.
   Conclusion: The use of XL-NPWT to treat extensive burns is feasible with attention to application technique. NPWT dressings appear to improve graft take, and to decrease risk of infection, LOS, and pain and anxiety associated with wound care. Measured fluid losses can improve patient care in future applications of NPWT to large burn wounds. (C) 2015 Elsevier Ltd and ISBI. All rights reserved.
C1 [Fischer, Sebastian; Pomahac, Bohdan; Halvorson, Eric G.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   [Fischer, Sebastian] Heidelberg Univ, Dept Hand Plast & Reconstruct Surg, Res Grp Trauma Meets Burn, Burn Trauma Ctr,BG Trauma Ctr Ludwigshafen, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
   [Wall, Jennifer; Riviello, Robert] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Trauma Burns & Surg Crit Care, 75 Francis St, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Ruprecht Karls University
   Heidelberg; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Brigham & Women's Hospital
RP Halvorson, EG (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM ehalvorson@partners.org
RI ; Pomahac, Bohdan/AAH-1792-2019; Fischer, Sebastian/AEX-5429-2022
OI , Sebastian/0000-0003-3445-1902; Pomahac, Bohdan/0000-0003-3703-8240; 
CR Aboelatta Y, 2013, J BURN CARE RES, V34, P349, DOI 10.1097/BCR.0b013e3182642b32
   [Anonymous], BURNS J INT SOC BURN
   [Anonymous], TOTAL BURN CARE
   [Anonymous], BURNS J INT SOC BURN
   [Anonymous], J BURN CARE RES OFF
   [Anonymous], TOTAL BURN CARE
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NR 41
TC 22
Z9 25
U1 0
U2 12
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAR
PY 2016
VL 42
IS 2
BP 457
EP 465
DI 10.1016/j.burns.2015.08.034
PG 9
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA DG6FW
UT WOS:000372179600034
PM 26774601
DA 2026-07-24
ER
PT J
AU Correa, JC
   Mejía, DA
   Duque, N
   Montoya, M
   Uribe, CM
AF Camilo Correa, J.
   Alejandro Mejia, D.
   Duque, N.
   Montoya J, M.
   Morales Uribe, C.
TI Managing the open abdomen: negative pressure closure versus
   mesh-mediated fascial traction closure: a randomized trial
SO HERNIA
LA English
DT Article
DE Open abdomen; Temporary abdominal closure; Negative pressure wound
   therapy; Mesh
ID VACUUM-ASSISTED CLOSURE; TEMPORARY ABDOMINAL CLOSURE; VENTRAL HERNIA;
   MANAGEMENT; TRAUMA; SURGERY; WOUNDS; ASSOCIATION; EXPERIENCE; EVOLUTION
AB To compare the effectiveness of abdominal wall closure using the vacuum-assisted closure (NPC) as described by Barker et al. with an institutional protocol using a double polyvinyl bag in the first surgery, which is changed in subsequent surgeries to a polyvinyl bag placed over the bowel loops and a prolene mesh attached to the abdominal fascia (MMFC).
   Randomized controlled trial. Patients with open abdomen (OA) due to a traumatic or a medical cause were included in the study. Variables studied included demographics, indication for surgery, number of interventions, hospital length of stay (HLOS), ICU length of stay, abdominal wound care costs, complication rates, and method and time to definitive fascial closure.
   From June 2011 to April 2013, 75 patients were enrolled in the study. Patients who died within 48 h were excluded; therefore, 53 patients in total were assessed. NPC achieved fascial closure in 75 % of patients, and MMFC achieved closure in 71.9 % of patients. The closure rates in patients with OA secondary to medical causes (80 % by NPC vs. 71.4 % by MMFC) or traumatic causes (70 % by NPC vs. 73.7 % by MMFC) were similar in both treatment groups. There were no differences between the groups with respect to cause of OA, complications, length of hospital stay, or the length of stay in the intensive care unit.
   MMFC is a method comparable to NPC for the temporary management of OA that results in similar closure and complication rates.
C1 [Camilo Correa, J.; Alejandro Mejia, D.; Montoya J, M.; Morales Uribe, C.] Univ Antioquia, Medellin, Colombia.
   [Duque, N.; Morales Uribe, C.] Hosp Univ San Vicente Fdn, Medellin, Colombia.
C3 Universidad de Antioquia
RP Correa, JC (通讯作者)，Univ Antioquia, Medellin, Colombia.
EM jcccote@yahoo.com; damt23@hotmail.com; nicoduque1960@gmail.com;
   marcelamj11@gmail.com; hernando.morales@udea.edu.co
RI ; Duque-Gardeazabal, Nicolas/OAL-0219-2025
OI Correa-Cote, Juan Camilo/0000-0001-5228-4007; 
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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   Vargo D, 2009, AM SURGEON, V75, pS1
   Wondberg D, 2008, WORLD J SURG, V32, P2724, DOI 10.1007/s00268-008-9762-y
NR 31
TC 16
Z9 22
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2016
VL 20
IS 2
BP 221
EP 229
DI 10.1007/s10029-016-1459-9
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DG8BD
UT WOS:000372306500005
PM 26833235
DA 2026-07-24
ER
PT J
AU Gupta, S
   Gabriel, A
   Lantis, J
   Teot, L
AF Gupta, Subhas
   Gabriel, Allen
   Lantis, John
   Teot, Luc
TI Clinical recommendations and practical guide for negative pressure wound
   therapy with instillation
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Dwell time; Instillation therapy; Negative pressure wound therapy;
   NPWTi-d; Wound healing
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; COST-EFFECTIVENESS;
   RANDOMIZED-TRIAL; MANAGEMENT; IMPACT; RECONSTRUCTION; MULTICENTER;
   EFFICACY; TRAUMA
AB Effective wound management involves a comprehensive assessment of the patient and the wound to determine an optimal wound treatment plan. It is critical to identify and address factors that may impair wound healing, prior to selecting the most appropriate therapy for each patient. Negative pressure wound therapy (NPWT) is a well-established advanced therapy that has been successful in adjunctive management of acute and chronic wounds. In recent years, the introduction of topical wound solution delivery in combination with NPWT has provided further benefits to wound healing. A commercially available system now offers automated, volumetric control of instilled topical wound solutions with a dwell time in combination with NPWT (NPWTi-d; V.A.C. VeraFlo Therapy, KCI, an Acelity company, San Antonio, TX). This NPWTi-d system differs from other instillation systems in that a timed, predetermined volume of topical wound solution is intermittently delivered (versus continuously fed) and allowed to dwell in the wound bed (without NPWT), for a user-selected period of time before NPWT is resumed. This added accuracy and process simplification of solution delivery in tandem with NPWT have prompted use of NPWTi-d as first-line therapy in a wider subset of complex wounds. However, considerably more research is required to validate efficacy of NPWTi-d in various wound types. The purpose of this review is to provide a relevant overview of wound healing, describe current literature supporting the adjunctive use of NPWTi-d, propose a clinical approach for appropriate application of NPWTi-d and conclude with case studies demonstrating successful use of NPWTi-d. Based on this review, we conclude that either a large case series examining effects of NPWTi-d on different wound types or possibly a large prospective registry evaluating NPWTi-d with real-world topical wound solutions versus immediate debridement and closure would be valuable to the medical community in evaluating the efficacy of this promising therapy.
C1 [Gupta, Subhas] Loma Linda Univ, Sch Med, Dept Plast Surg, 11175 Campus Dr,Coleman Pavil 21226, Loma Linda, CA 92354 USA.
   [Gabriel, Allen] PeaceHlth Med Grp Plast Surg, Vancouver, WA USA.
   [Lantis, John] Mt Sinai St Lukes Roosevelt Hosp, Dept Vasc Surg, New York, NY USA.
   [Teot, Luc] Montpellier Univ Hosp, Wound Healing Unit, Montpellier, France.
C3 Loma Linda University; Mount Sinai Morningside; Mount Sinai West;
   Universite de Montpellier; CHU de Montpellier
RP Gupta, S (通讯作者)，Loma Linda Univ, Sch Med, Dept Plast Surg, 11175 Campus Dr,Coleman Pavil 21226, Loma Linda, CA 92354 USA.
EM sgupta@llu.edu
RI Gabriel, Allen/AFK-3548-2022; Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922
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   Schultz Gregory S, 2004, Int Wound J, V1, P19, DOI 10.1111/j.1742-481x.2004.00008.x
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   Stannard JR, 2009, OSTOMY WOUND MANAG, V55, P58
   Sumpio BE, 2009, WOUNDS, P3
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
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   Wolvos T, 2013, WOUNDS, V25, P75
NR 62
TC 112
Z9 140
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2016
VL 13
IS 2
BP 159
EP 174
DI 10.1111/iwj.12452
PG 16
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DH2UF
UT WOS:000372641400002
PM 26011379
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Ida, Y
   Matsumura, H
   Onishi, M
   Ono, S
   Imai, R
   Watanabe, K
AF Ida, Yukiko
   Matsumura, Hajime
   Onishi, Masami
   Ono, Sayaka
   Imai, Ryutaro
   Watanabe, Katsueki
TI Measurement of vancomycin hydrochloride concentration in the exudate
   from wounds receiving negative pressure wound therapy: a pilot study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Exudate; Infection; Negative pressure wound therapy; Vancomycin
ID VACUUM-ASSISTED CLOSURE; PENETRATION; TISSUE; PHARMACOKINETICS;
   INFUSION; SURGERY; FLUID
AB It has been reported that negative pressure wound therapy (NPWT) is effective in the treatment of contaminated wounds. We hypothesised that systemically administered antibiotics migrate to wound site effectively by NPWT, which provides the antibacterial effect. We measured and compared the concentrations of vancomycin in the exudate and blood serum. Eight patients with skin ulcers or skin defect wounds who were treated with NPWT and were administered an intravenous drip of vancomycin were enrolled in this study. The wound surfaces were muscle, muscle fascia or adipose tissue. We administered vancomycin intravenously to NPWT patients (1-3g/day). The exudate was obtained using 500 ml V.A.C. ATS((R)) canisters without gel. Three days later, the concentrations of vancomycin were measured. The mean concentration of vancomycin in the exudate from NPWT was 67% of the serum vancomycin concentration. We found that concentrations of vancomycin in NPWT exudates are higher than the previously reported concentrations in soft tissue without NPWT. The proactive use of NPWT might be considered in cases of suspected wound contamination when a systemic antibiotic is administered.
C1 [Ida, Yukiko; Matsumura, Hajime; Ono, Sayaka; Imai, Ryutaro; Watanabe, Katsueki] Tokyo Med Univ, Dept Plast & Reconstruct Surg, Tokyo 1600023, Japan.
   [Onishi, Masami] Tokyo Med Univ Hosp, Div Pharm, Tokyo, Japan.
C3 Tokyo Medical University; Tokyo Medical University
RP Matsumura, H (通讯作者)，Tokyo Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, 6-7-1 Nishishinjuku, Tokyo 1600023, Japan.
EM hmatsu-tki@umin.ac.jp
CR Banwell P E, 1999, J Wound Care, V8, P79
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NR 28
TC 8
Z9 11
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2016
VL 13
IS 2
BP 204
EP 208
DI 10.1111/iwj.12260
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DH2UF
UT WOS:000372641400007
PM 24674131
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Chopra, K
   Tadisina, KK
   Singh, DP
AF Chopra, Karan
   Tadisina, Kashyap K.
   Singh, Devinder P.
TI The "French Fry' VAC technique: hybridisation of traditional open wound
   NPWT with closed incision NPWT
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Closed incision NPWT; Negative pressure wound therapy; Open wound NPWT;
   Surgical site infection; French fry
ID INFECTIONS; MANAGEMENT
AB Surgical site occurrences (SSO), specifically surgical site infections represent a significant burden in the US health care system. It has been hypothesised that postoperative dressing can help drive down SSO. We describe the successful use of a novel technique combining both closed incision and open negative pressure wound therapy in the management of a high-risk wound associated with lymphoedema of obesity.
C1 [Chopra, Karan; Singh, Devinder P.] Univ Maryland, Med Ctr, Dept Surg, Div Plast Surg, Baltimore, MD 21201 USA.
   [Chopra, Karan] Johns Hopkins Univ, Sch Med, Dept Plast Surg, Baltimore, MD USA.
   [Tadisina, Kashyap K.] Univ Illinois, Coll Med, Chicago, IL USA.
C3 University System of Maryland; University of Maryland Baltimore; Johns
   Hopkins University; University of Illinois System; University of
   Illinois Chicago; University of Illinois Chicago Hospital
RP Singh, DP (通讯作者)，Univ Maryland, Sch Med, Div Plast Surg, Surg, 22 S Greene St, Baltimore, MD 21201 USA.
EM dsingh@smail.umaryland.edu
RI Singh, Devinder/AAN-4716-2021
CR Bollero D, 2013, INT WOUND J
   Chopra K, 2013, ANN PLAST SURG
   Condé-Green A, 2013, ANN PLAS SURG, V71, P394, DOI 10.1097/SAP.0b013e31824c9073
   Guerra O, 2014, HERNIA, V18, P71, DOI 10.1007/s10029-013-1148-x
   Rispoli DM, 2010, J TRAUMA, V68, P1247, DOI 10.1097/TA.0b013e3181d3cc3c
   Tadisina Kashyap K, 2013, Eplasty, V13, pic60
   Thorne CH, 2007, GRABB SMITHS PLASTIC, P23
   Zimlichman E, 2013, JAMA INTERN MED, V173, P2039, DOI 10.1001/jamainternmed.2013.9763
NR 8
TC 8
Z9 8
U1 0
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2016
VL 13
IS 2
BP 216
EP 219
DI 10.1111/iwj.12266
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DH2UF
UT WOS:000372641400009
PM 24698495
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Moradian, S
   Klapper, AM
AF Moradian, Scott
   Klapper, Andrew M.
TI A novel way to treat skin tears
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Random pattern flap; Skin graft; Skin
   tear; Wound treatment
AB Skin tears are one of the most commonly treated wounds in the elderly population. In their most basic form, they are essentially traumatic random pattern flaps. We postulate that the injured blood flow to these skin flaps should be ignored and the tissue should be treated as a skin graft. A case report is presented of an 86-year-old female with an 8 x 35 cm skin tear to her right upper extremity after a hip fracture. In addition to conventional wound closure strips re-approximating the tissues, a disposable negative pressure wound therapy device was placed to act as bolster. Upon its removal on day 5, the opposed skin tear tissue was found to be 100% viable. We therefore propose that this update may be an improvement over classical skin tear treatments and should be followed up with a case series.
C1 [Moradian, Scott] Delray Med Ctr, Dept Gen Surg, Delray Beach, FL 33446 USA.
   [Klapper, Andrew M.] Delray Med Ctr, Wound Treatment Ctr, Delray Beach, FL 33446 USA.
RP Klapper, AM (通讯作者)，Delray Med Ctr, 13660 Jog Rd,Suite 4, Delray Beach, FL 33446 USA.
EM Klappermd@AndrewKlapper.com
CR Carville K, 2007, WOUND PRACT RES, V15, P18
   Clemens Mark W, 2010, Semin Plast Surg, V24, P43, DOI 10.1055/s-0030-1253239
   LeBlanc K, 2009, ADV SKIN WOUND CARE, V22, P325, DOI 10.1097/01.ASW.0000305484.60616.e8
   LeBlanc K, 2014, INT WOUND J, V11, P424, DOI 10.1111/iwj.12203
   LeBlanc Kimberly, 2011, Adv Skin Wound Care, V24, P2, DOI 10.1097/01.ASW.0000405316.99011.95
   Payne R L, 1993, Ostomy Wound Manage, V39, P16
   Vandervord JG, 2016, INT WOUND J, V13, P59, DOI 10.1111/iwj.12227
NR 7
TC 3
Z9 4
U1 0
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2016
VL 13
IS 2
BP 283
EP 286
DI 10.1111/iwj.12426
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DH2UF
UT WOS:000372641400021
PM 25756343
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Acosta, S
   Wanhainen, A
   Björck, M
AF Acosta, S.
   Wanhainen, A.
   Bjorck, M.
TI Temporary Abdominal Closure After Abdominal Aortic Aneurysm Repair: A
   Systematic Review of Contemporary Observational Studies
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE Temporary abdominal closure; Open abdomen; Aortic aneurysm; Negative
   pressure wound therapy
ID ASSISTED WOUND CLOSURE; MEDIATED FASCIAL TRACTION; REINFORCED TENSION
   LINE; OPEN ABDOMEN TREATMENT; COMPARTMENT SYNDROME; INTRAABDOMINAL
   HYPERTENSION; ENDOVASCULAR REPAIR; VACUUM; MANAGEMENT; METAANALYSIS
AB Objectives: The aim of this paper was to review the literature on temporary abdominal closure (TAC) after abdominal aortic aneurysm (AAA) repair.
   Methods: This was a systematic review of observational studies. A PubMed, EM BASE and Cochrane search from 2007 to July 2015 was performed combining the Medical Subject Headings "aortic aneurysm" and "temporary abdominal closure", "delayed abdominal closure", "open abdomen", "abdominal compartment syndrome", "negative pressure wound therapy", or "vacuum assisted wound closure".
   Results: Seven original studies were found. The methods used for TAC were the vacuum pack system with (n = 1) or without (n = 2) mesh bridge, vacuum assisted wound closure (VAWC; n = 1) and the VAWC with mesh mediated fascial traction (VACM; n = 3). The number of patients included varied from four to 30. Three studies were exclusively after open repair, one after endovascular aneurysm repair, and three were mixed series. The frequency of ruptured AAA varied from 60% to 100%. The primary fascia] closure rate varied from 79% to 100%. The median time to closure of the open abdomen was 10.5 and 17 days in two prospective studies with a fascia] closure rate of 100% and 96%, respectively; the inclusion criterion was an anticipated open abdomen therapy time >= 5 days using the VACM method. The graft infection rate was 0% in three studies. No patient with longterm open abdomen therapy with the VACM in the three studies was left with a planned ventral hernia. The in hospital survival rate varied from 46% to 80%.
   Conclusions: A high fascial closure rate without planned ventral hernia is possible to achieve with VACM, even after long-term open abdomen therapy. There are, however, few publications reporting specific results of open abdomen treatment after AAA repair, and there is a need for randomized controlled trials to determine the most efficient and safe TAC method during open abdomen treatment after AAA repair. (C) 2015 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Acosta, S.] Lund Univ, Vasc Ctr, Dept Clin Sci, Malmo, Sweden.
   [Wanhainen, A.; Bjorck, M.] Uppsala Univ, Dept Surg Sci, Vasc Surg, Uppsala, Sweden.
C3 Lund University; Uppsala University
RP Acosta, S (通讯作者)，Skane Univ Hosp, Vasc Ctr Malmo, S-20502 Malmo, Sweden.
EM stefan.acosta@telia.com
RI Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Agarwal A, 2011, TROP DOCT, V41, P193, DOI 10.1258/td.2011.110045
   Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
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   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Barker DE, 2007, J AM COLL SURGEONS, V204, P784, DOI 10.1016/j.jamcollsurg.2006.12.039
   Björck M, 2014, EUR J VASC ENDOVASC, V47, P279, DOI 10.1016/j.ejvs.2013.12.014
   Björck M, 2012, SEMIN VASC SURG, V25, P35, DOI 10.1053/j.semvascsurg.2012.03.002
   Björck M, 2009, WORLD J SURG, V33, P1154, DOI 10.1007/s00268-009-9996-3
   Cheatham ML, 2013, WORLD J SURG, V37, P2018, DOI 10.1007/s00268-013-2080-z
   Cheatham ML, 2010, CRIT CARE MED, V38, P402, DOI 10.1097/CCM.0b013e3181b9e9b1
   Cothren CC, 2006, AM J SURG, V192, P238, DOI 10.1016/j.amjsurg.2006.04.010
   Frazee RC, 2013, J AM COLL SURGEONS, V216, P730, DOI 10.1016/j.jamcollsurg.2012.12.035
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   Kimball EJ, 2009, VASCULAR, V17, P309, DOI 10.2310/6670.2009.00048
   Kirkendall A, 2015, AM J HOSP PALLIAT ME, V32, P313, DOI 10.1177/1049909114526969
   Kirkpatrick AW, 2013, INTENS CARE MED, V39, P1190, DOI 10.1007/s00134-013-2906-z
   Mayer D, 2009, J VASC SURG, V50, P1, DOI 10.1016/j.jvs.2008.12.030
   Mukhi AN, 2014, CAN J SURG, V57, P314, DOI 10.1503/cjs.026613
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   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   Pommerening MJ, 2014, SURGERY, V156, P431, DOI 10.1016/j.surg.2014.04.019
   Rasilainen S, 2015, SCAND J SURG
   Rasilainen SK, 2012, BRIT J SURG, V99, P1725, DOI 10.1002/bjs.8914
   Roberts DJ, 2012, J TRAUMA ACUTE CARE, V73, P629, DOI 10.1097/TA.0b013e31825c130e
   Ross CB, 2009, AM SURGEON, V75, P565
   Rubenstein C, 2015, J VASC SURG, V61, P648, DOI 10.1016/j.jvs.2014.10.011
   Sammons A, 2009, CLIN S ADV SKIN WOUN
   Seternes A, 2010, EUR J VASC ENDOVASC, V40, P60, DOI 10.1016/j.ejvs.2010.02.018
   Sörelius K, 2013, EUR J VASC ENDOVASC, V45, P588, DOI 10.1016/j.ejvs.2013.01.041
   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
   Willms A, 2015, LANGENBECK ARCH SURG, V400, P91, DOI 10.1007/s00423-014-1240-4
NR 33
TC 24
Z9 27
U1 0
U2 7
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD MAR
PY 2016
VL 51
IS 3
BP 371
EP 378
DI 10.1016/j.ejvs.2015.10.014
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA DH3LZ
UT WOS:000372689800010
PM 26652956
OA Bronze
DA 2026-07-24
ER
PT J
AU Ma, ZJ
   Shou, KQ
   Li, ZH
   Jian, C
   Qi, BW
   Yu, AX
AF Ma, Zhanjun
   Shou, Kangquan
   Li, Zonghuan
   Jian, Chao
   Qi, Baiwen
   Yu, Aixi
TI Negative pressure wound therapy promotes vessel destabilization and
   maturation at various stages of wound healing and thus influences wound
   prognosis
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE negative pressure wound therapy; pericyte; vessel maturation; wound
   prognosis
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; CANCER-PATIENTS;
   GROWTH-FACTORS; IN-VIVO; ANGIOGENESIS; PERICYTES; ANGIOPOIETIN-2;
   EXPRESSION; TISSUE
AB Negative pressure wound therapy (NPWT) has been observed to accelerate the wound healing process in humans through promoting angiogenesis. However, the potential biological effect and relevant molecular mechanisms, including microvessel destabilization, regression and endothelial cell proliferation in the early stage (1-3 days), and the neovascular stabilization and maturation in the later stage (7-15 days), have yet to be fully elucidated. The current study aimed to research the potential effect of NPWT on angiogenesis and vessel maturation, and investigate relevant association between mature microvessels and wound prognosis, as well as the regulatory mechanisms in human wound healing. Patients in the present study (n= 48) were treated with NPWT or a petrolatum gauze, and relevant growth factors and vessel changes were detected using various experimental methods. NPWT increased the expression levels of angiogenin-2 (Ang-2), and decreased the expression levels of Ang-1 and ratios of Ang-1/Ang-2 in the initial stages of wound healing. However, in the latter stages of wound healing, NPWT increased the expression levels of Ang-1 and ratios of Ang-1/Ang-2, as well as the phosphorylation level of tyrosine kinase receptor-2. Consequently, microvessel pericyte coverage was gradually elevated, and the basement membrane was gradually supplied with new blood at the later stage of wound healing. In conclusion, NPWT may preferentially stimulate microvessel destabilization and regression in the early stage of wound healing, and as a consequence, increase angiogenesis. Subsequently, in the later stage of wound healing, NPWT may preferentially promote microvessel stabilization, thereby promoting microvessel maturation in human wounds through the angiogenin/tyrosine kinase receptor-2 signaling pathway. The results of the present study results demonstrated that NPWT was able to accelerate wound healing speed, and thus influence wound prognosis, as a result of an abundance of mature microvessels in human wounds.
C1 [Ma, Zhanjun; Shou, Kangquan; Li, Zonghuan; Jian, Chao; Qi, Baiwen; Yu, Aixi] Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Qi, BW; Yu, AX (通讯作者)，Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM wb002162@whu.edu.cn; yuaixi@whu.edu.cn
RI /E-6566-2018
FU National Natural Science Foundation of China [81572163]; Hubei National
   Natural Science Fund projects [2014CFB751]
FX The present study was supported by the National Natural Science
   Foundation of China (grant no. 81572163) and by Hubei National Natural
   Science Fund projects (grant no. 2014CFB751). The authors would also
   like to acknowledge the Wuhan VSD Medical Science & Technology, Co.,
   Ltd. (Wuhan, China) for supplying the vacuum material. Finally, thanks
   is given to the Medical Science Experimentation Center of Wuhan
   University for providing the experimental equipment.
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NR 50
TC 41
Z9 55
U1 0
U2 16
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD APR
PY 2016
VL 11
IS 4
BP 1307
EP 1317
DI 10.3892/etm.2016.3083
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DH3TN
UT WOS:000372709800026
PM 27073441
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rasilainen, SK
   Mentula, PJ
   Leppäniemi, AK
AF Rasilainen, S. K.
   Mentula, P. J.
   Leppaniemi, A. K.
TI Components separation technique is feasible for assisting delayed
   primary fascial closure of open abdomen
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Open abdomen; primary fascial closure; components separation; abdominal
   compartment syndrome; temporary abdominal closure; vacuum-assisted wound
   closure
ID ABDOMINAL-WALL DEFECTS; INTRAABDOMINAL HYPERTENSION; STAGED MANAGEMENT;
   CRITICALLY-ILL; HERNIA; RECONSTRUCTION; VACUUM; MESH; TRACTION; OUTCOMES
AB Background and aims: The goal after open abdomen treatment is to reach primary fascial closure. Modern negative pressure wound therapy systems are sometimes inefficient for this purpose. This retrospective chart analysis describes the use of the components separation' method in facilitating primary fascial closure after open abdomen.
   Material and methods: A total of 16 consecutive critically ill surgical patients treated with components separation during open abdomen management were analyzed. No patients were excluded.
   Results: Primary fascial closure was achieved in 75% (12/16). Components separation was performed during ongoing open abdomen treatment in 7 patients and at the time of delayed primary fascial closure in 9 patients. Of the former, 3/7 (43%) patients reached primary fascial closure, whereas all 9 patients in the latter group had successful fascial closure without major complications (p=0.019).
   Conclusion: Components separation is a useful method in contributing to successful primary fascial closure in patients treated for open abdomen. Best results were obtained when components separation was performed simultaneously with primary fascial closure at the end of the open abdomen treatment.
C1 [Rasilainen, S. K.] Jorvi Hosp, Dept Abdominal Surg, SF-02740 Espoo, Finland.
   [Mentula, P. J.; Leppaniemi, A. K.] Univ Helsinki, Cent Hosp, Dept Abdominal Surg, Helsinki, Finland.
C3 University of Helsinki; Helsinki University Central Hospital
RP Rasilainen, SK (通讯作者)，Pihlajatie 6A,POB 02270, Espoo, Finland.
EM rasilainensuvi@gmail.com
RI Mentula, Panu/H-9025-2019; Leppäniemi, Ari/GQZ-7991-2022
OI Mentula, Panu/0000-0002-6516-3797; 
FU Helsinki University Hospital
FX This study was financially supported only by a Helsinki University
   Hospital research grant for emergency abdominal surgery.
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NR 29
TC 18
Z9 19
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD MAR
PY 2016
VL 105
IS 1
BP 17
EP 21
DI 10.1177/1457496915586651
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DH5LI
UT WOS:000372830000004
PM 25972489
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Serena, TE
   Buan, JS
AF Serena, Thomas E.
   Buan, John S.
TI The Use of a Novel Canister-free Negative-Pressure Device in Chronic
   Wounds A Retrospective Analysis
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative-pressure wound therapy; chronic wound healing; retrospective
   study
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE
AB OBJECTIVE:
   Negative-pressure wound therapy (NPWT) is a mainstay in the treatment of acute and chronic wounds. Following the success of the Vacuum-Assisted Closure system (Kinetic Concepts Inc [KCI], an Acelity Company, San Antonio, Texas), many similar systems were developed with minor variations. However, these systems are best suited to wounds with soft-tissue defects. Moreover, the need for a canister to collect wound exudate adds to the size and weight of the device. A canister-free (CF) NPWT device was cleared by the FDA for the treatment of chronic wounds (Kalypto Medical, Mendota Heights, Minnesota). A retrospective study was designed to evaluate the effectiveness of the CF-NPWT device in promoting wound healing.
   METHODS:
   The authors examined the records of 51 patients treated with the CF-NPWT device over a 21-month period. Study participants were treated in an outpatient setting, had at least 30 days of prior treatment, and carried insurance coverage through Medicare or Medicaid. The comparison of time to heal between groups was conducted using the log-rank, Breslow, and Tarone-Ware tests in conjunction with a Kaplan-Meier analysis.
   RESULTS:
   In the study population, 65% of the wounds achieved complete closure. For unhealed wounds, the mean wound area reduction was 31.9%, and the mean wound depth reduction was 57.5%. The mean time to heal was 56.9 days (95% confidence interval, 46.4-67.4 days).
   CONCLUSIONS:
   The results show that the CF-NPWT system meets or exceeds healing rates previously reported in the literature for canister-based systems. This CF device offers a more portable NPWT option, particularly effective in the treatment of shallow wounds.
C1 [Serena, Thomas E.] SerenaGroup, Cambridge, MA USA.
   [Buan, John S.] Bioadaptive LLC, St Paul, MN USA.
RP Serena, TE (通讯作者)，SerenaGroup, Cambridge, MA USA.
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Orgill DP, 2009, SURGERY, V146, P40, DOI 10.1016/j.surg.2009.02.002
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
   Yang Charlie C, 2006, J Surg Orthop Adv, V15, P19
NR 5
TC 1
Z9 1
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD APR
PY 2016
VL 29
IS 4
BP 165
EP 168
DI 10.1097/01.ASW.0000481188.31032.52
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA DH5RH
UT WOS:000372849000001
PM 26978800
DA 2026-07-24
ER
PT J
AU Anderson, CA
   Hare, MA
   Perdrizet, GA
AF Anderson, Caesar A.
   Hare, Marc A.
   Perdrizet, George A.
TI Wound Healing Devices Brief Vignettes
SO ADVANCES IN WOUND CARE
LA English
DT Review
ID HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED CLOSURE; RANDOMIZED
   CONTROLLED-TRIAL; DIABETIC FOOT ULCERS; SOFT-TISSUE INFECTIONS; PRESSURE
   ULCERS; DOUBLE-BLIND; ULTRASOUND; MULTICENTER; MANAGEMENT
AB Significance: The demand for wound care therapies is increasing. New wound care products and devices are marketed at a dizzying rate. Practitioners must make informed decisions about the use of medical devices for wound healing therapy. This paper provides updated evidence and recommendations based on a review of recent publications.
   Recent Advances: The published literature on the use of medical devices for wound healing continues to support the use of hyperbaric oxygen therapy, negative pressure wound therapy, and most recently electrical stimulation.
   Critical Issue: To inform wound healing practitioners of the evidence for or against the use of medical devices for wound healing. This information will aid the practitioner in deciding which technology should be accepted or rejected for clinical use.
   Future Directions: To produce high quality, randomized controlled trials or acquire outcome-based registry databases to further test and improve the knowledge base as it relates to the use of medical devices in wound care.
C1 [Anderson, Caesar A.; Hare, Marc A.; Perdrizet, George A.] Univ Calif San Diego, Dept Emergency Med, Ctr Wound Healing & Hyperbar Med, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego
RP Perdrizet, GA (通讯作者)，UC San Diego Hlth Syst, Dept Emergency Med, 200 W Arbor Dr,MC8676, San Diego, CA 92103 USA.
EM gperdrizet@UCSD.edu
FU OxyHeal Corp. (San Diego, CA)
FX C.A.A., M.A.H., and G.A.P. have no competing financial interests. G.A.P.
   has received funding for basic science research from OxyHeal Corp. (San
   Diego, CA). The content of this article was expressly written by the
   authors listed. No ghostwriters were used to write this article.
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NR 46
TC 8
Z9 8
U1 2
U2 19
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD APR 1
PY 2016
VL 5
IS 4
BP 185
EP 190
DI 10.1089/wound.2015.0651
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DH5RU
UT WOS:000372850300004
PM 27076996
DA 2026-07-24
ER
PT J
AU Hyldig, N
   Birke-Sorensen, H
   Kruse, M
   Vinter, C
   Joergensen, JS
   Sorensen, JA
   Mogensen, O
   Lamont, RF
   Bille, C
AF Hyldig, N.
   Birke-Sorensen, H.
   Kruse, M.
   Vinter, C.
   Joergensen, J. S.
   Sorensen, J. A.
   Mogensen, O.
   Lamont, R. F.
   Bille, C.
TI Meta-analysis of negative-pressure wound therapy for closed surgical
   incisions
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; HIGH-RISK; SITE INFECTION; GUIDELINES;
   MANAGEMENT; PREVENTION; QUALITY; GAUZE
AB Background: Postoperative wound complications are common following surgical procedures. Negative-pressure wound therapy (NPWT) is well recognized for the management of open wounds and has been applied recently to closed surgical incisions. The evidence base to support this intervention is limited. The aim of this study was to assess whether NPWT reduces postoperative wound complications when applied to closed surgical incisions.
   Methods: This was a systematic review and meta-analysis of randomized clinical trials of NPWT compared with standard postoperative dressings on closed surgical incisions.
   Results: Ten studies met the inclusion criteria, reporting on 1311 incisions in 1089 patients. NPWT was associated with a significant reduction in wound infection (relative risk (RR) 054, 95 per cent c.i. 033 to 089) and seroma formation (RR 048, 027 to 084) compared with standard care. The reduction in wound dehiscence was not significant. The numbers needed to treat were three (seroma), 17 (dehiscence) and 25 (infection). Methodological heterogeneity across studies led to downgrading of the quality of evidence to moderate for infection and seroma, and low for dehiscence.
   Conclusion: Compared with standard postoperative dressings, NPWT significantly reduced the rate of wound infection and seroma when applied to closed surgical wounds. Heterogeneity between the included studies means that no general recommendations can be made yet.
C1 [Hyldig, N.; Sorensen, J. A.; Bille, C.] Univ Southern Denmark, Inst Clin Res, Res Unit Plast Surg, Dept Plast Surg,Odense Univ Hosp, Odense, Denmark.
   [Hyldig, N.; Vinter, C.; Joergensen, J. S.; Mogensen, O.; Lamont, R. F.] Univ Southern Denmark, Inst Clin Res, Res Unit Gynaecol & Obstet, Dept Gynaecol & Obstet,Odense Univ Hosp, Odense, Denmark.
   [Kruse, M.] Univ Southern Denmark, Ctr Hlth Econ Res COHERE, Odense, Denmark.
   [Birke-Sorensen, H.] Aarhus Univ Hosp, Inst Clin Med, DK-8000 Aarhus, Denmark.
   [Lamont, R. F.] UCL, Northwick Pk Inst, Div Surg, Med Res Campus, London, England.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Aarhus University; University of London; University College
   London
RP Hyldig, N (通讯作者)，Odense Univ Hosp, Kloevervaenget 10,10th Floor, DK-5000 Odense, Denmark.
EM nana.hyldig@rsyd.dk
RI Birke-Sørensen, Hanne/B-6733-2015; Sørensen, Jens Ahm/D-6279-2014;
   Hyldig, Nana/AAH-5220-2020; Mogensen, Ole/Q-1894-2015
OI Sørensen, Jens Ahm/0000-0003-4903-0094; Hyldig,
   Nana/0000-0001-6758-6294; jørgensen, jan stener/0000-0001-5222-2535;
   Vinter, Christina Anne/0000-0001-5084-6053; Mogensen,
   Ole/0000-0001-7655-9909
FU manufacturer Smith Nephew
FX The authors are currently conducting a RCT of iNPWT that is partly
   funded by the manufacturer Smith & Nephew. They received an unrestricted
   grant of 61 pound 093 (approximately (sic)87 000, exchange rate 30
   November 2015) and 500 PICO (TM) dressings free of charge.
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NR 45
TC 192
Z9 214
U1 0
U2 27
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD APR
PY 2016
VL 103
IS 5
BP 477
EP 486
DI 10.1002/bjs.10084
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DH6PU
UT WOS:000372914100002
PM 26994715
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Mitchell, SJ
   Jeyapalina, S
   Nichols, FR
   Agarwal, J
   Bachus, KN
AF Mitchell, Saranne J.
   Jeyapalina, Sujee
   Nichols, Francesca R.
   Agarwal, Jayant
   Bachus, Kent N.
TI Negative pressure wound therapy limits downgrowth in percutaneous
   devices
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SKIN-IMPLANT INTERFACE; TRANSFEMORAL
   AMPUTATION; STEM-CELLS; IN-VITRO; TITANIUM; TISSUE; MODEL; ATTACHMENT;
   PROSTHESES
AB Maintenance of a soft tissue seal around percutaneous devices is challenged by the downgrowth of periprosthetic tissuesa gateway to potential infection. As negative pressure wound therapy (NPWT) is used clinically to facilitate healing of complex soft tissue pathologies, it was hypothesized that NPWT could limit downgrowth of periprosthetic tissues. To test this hypothesis, 20 hairless guinea pigs were randomly assigned into four groups (n=5/group). Using a One-Stage (Groups 1 and 3) or a Two-Stage (Groups 2 and 4) surgical procedure, each animal was implanted with a titanium-alloy subdermal device porous-coated with commercially pure, medical grade titanium. Each subdermal device had a smooth titanium-alloy percutaneous post. The One-Stage procedure encompassed insertion of a fully assembled device during a single surgery. The Two-Stage procedure involved the implantation of a subdermal device during the first surgery, and then three weeks later, insertion of a percutaneous post. Groups 1 and 2 served as untreated controls and Groups 3 and 4 received NPWT. Four weeks postimplantation of the post, the devices and surrounding tissues were harvested, and histologically evaluated for downgrowth. Within the untreated control groups, the Two-Stage surgical procedure significantly decreased downgrowth (p=0.027) when compared with the One-Stage procedure. Independent of the surgical procedures performed, NPWT significantly limited downgrowth (p0.05) when compared with the untreated controls.
C1 [Mitchell, Saranne J.; Jeyapalina, Sujee; Nichols, Francesca R.; Bachus, Kent N.] Univ Utah, Dept Orthopaed, Orthopaed Res Lab, Salt Lake City, UT USA.
   [Mitchell, Saranne J.; Jeyapalina, Sujee; Nichols, Francesca R.; Bachus, Kent N.] George E Wahlen Dept Vet Affairs Med Ctr, Res Serv, Orthopaed Res Lab, Salt Lake City, UT USA.
   [Mitchell, Saranne J.; Jeyapalina, Sujee; Bachus, Kent N.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
   [Agarwal, Jayant] Univ Utah, Sch Med, Dept Surg, Salt Lake City, UT USA.
C3 Utah System of Higher Education; University of Utah; US Department of
   Veterans Affairs; Utah System of Higher Education; University of Utah;
   Utah System of Higher Education; University of Utah
RP Bachus, KN (通讯作者)，Univ Utah, Orthopaed Res Lab, Orthopaed Ctr, 590 Wakara Way,Suite A100, Salt Lake City, UT 84108 USA.
EM kent.bachus@hsc.utah.edu
RI ; Bachus, Kent/KYO-7869-2024
OI Mitchell, Saranne J/0000-0002-6473-7648; 
FU US Army Medical Research Materiel Command [W81XWH-11-1-0435]; United
   States Department of Veterans Affairs Rehabilitation Research and
   Development Service [I01RX001217]; Department of Orthopaedics,
   University of Utah, Salt Lake City, Utah; US Army Medical Research
   Acquisition Activity (Fort Detrick, MD, USA)
FX Funding support was cumulatively provided from the US Army Medical
   Research Materiel Command (Award #W81XWH-11-1-0435), the United States
   Department of Veterans Affairs Rehabilitation Research and Development
   Service (Award #I01RX001217), and the Department of Orthopaedics,
   University of Utah, Salt Lake City, Utah. While the US Army Medical
   Research Acquisition Activity (Fort Detrick, MD, USA) awarded and
   administering acquisition office, the content of this research does not
   necessarily reflect the position or the policy of the Government, and no
   official endorsement should be inferred.
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NR 40
TC 12
Z9 16
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN-FEB
PY 2016
VL 24
IS 1
BP 35
EP 44
DI 10.1111/wrr.12373
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DH6TT
UT WOS:000372925500004
PM 26487170
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Kuehn, F
   Schiffmann, L
   Janisch, F
   Schwandner, F
   Alsfasser, G
   Gock, M
   Klar, E
AF Kuehn, Florian
   Schiffmann, Leif
   Janisch, Florian
   Schwandner, Frank
   Alsfasser, Guido
   Gock, Michael
   Klar, Ernst
TI Surgical Endoscopic Vacuum Therapy for Defects of the Upper
   Gastrointestinal Tract
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article
DE Anastomotic leakage; Perforation; Esophageal; Endoscopy; Endoscopic
   vacuum therapy
ID ESOPHAGEAL-PERFORATION; ASSISTED CLOSURE; PRIMARY REPAIR; MANAGEMENT;
   EXPERIENCE; COMPLICATIONS; OPTIONS; CANCER; STENT
AB Introduction Intraluminal therapy used in the gastrointestinal (GI) tract was first shown for anastomotic leaks after rectal resection. Since a few years vacuum sponge therapy is increasingly being recognized as a new promising method for repairing upper GI defects of different etiology. The principles of vacuum-assisted closure (VAC) therapy remain the same no matter of localization: Continuous or intermittent suction and drainage decrease bacterial contamination, secretion, and local edema. At the same time, perfusion and granulation is promoted. However, data for endoscopic vacuum therapy (EVT) of the upper intestinal tract are still scarce and consist of only a few case reports and small series with low number of patients.
   Objectives Here, we present a single center experience of EVT for substantial wall defects in the upper GI tract.
   Methods Retrospective single-center analysis of EVT for various defects of the upper GI tract over a time period of 4 years (2011-2015) with a mean follow-up of 17 (2-45) months was used. If necessary, initial endoscopic sponge placement was performed in combination with open surgical revision.
   Results In total, 126 polyurethane sponges were placed in upper gastrointestinal defects of 21 patients with a median age of 72 years (range, 49-80). Most frequent indication for EVT was anastomotic leakage after esophageal or gastric resection (n = 11) and iatrogenic esophageal perforation (n = 8). The median number of sponge insertions was five (range, 1-14) with a mean changing interval of 3 days (range, 2-4). Median time of therapy was 15 days (range, 3-46). EVT in combination with surgery took place in nine of 21 patients (43 %). A successful vacuum therapy for upper intestinal defects with local control of the septic focus was achieved in 19 of 21 patients (90.5 %).
   Conclusion EVT is a promising approach for postoperative, iatrogenic, or spontaneous lesions of the upper GI tract. In this series, EVT was combined with operative revision in a relevant proportion of patients.
C1 [Kuehn, Florian; Schiffmann, Leif; Janisch, Florian; Schwandner, Frank; Alsfasser, Guido; Gock, Michael; Klar, Ernst] Univ Rostock, Dept Gen Thorac Vasc & Transplantat Surg, Schillingallee 35, D-18057 Rostock, Germany.
   [Schiffmann, Leif] Protestant Hosp Lippstadt, Wiedenbrucker Str 33, D-59555 Lippstadt, Germany.
C3 University of Rostock
RP Kuehn, F (通讯作者)，Univ Rostock, Dept Gen Thorac Vasc & Transplantat Surg, Schillingallee 35, D-18057 Rostock, Germany.
EM florian.kuehn@med.uni-rostock.de
OI Kühn, Florian/0000-0001-9830-3015
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NR 21
TC 69
Z9 85
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD FEB
PY 2016
VL 20
IS 2
BP 237
EP 242
DI 10.1007/s11605-015-3044-4
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA DI0BD
UT WOS:000373158900002
PM 26643296
DA 2026-07-24
ER
PT J
AU Karapinar, K
   Saydam, Ö
   Metin, M
   Erdogan, S
   Aker, C
   Arik, B
   Citak, N
AF Karapinar, Kemal
   Saydam, Ozkan
   Metin, Muzaffer
   Erdogan, Sertan
   Aker, Cemal
   Arik, Burcu
   Citak, Necati
TI Experience with Vacuum-Assisted Closure in the Management of
   Postpneumonectomy Empyema: An Analysis of Eight Cases
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE vacuum-assisted closure; empyema; pneumonectomy
ID NEGATIVE-PRESSURE; WOUND CONTROL; PROMOTE
AB Background The treatment of postpneumonectomic empyema is challenging. The aim of this study was to test the efficacy of vacuum-assisted closure (VAC) in the treatment of patients with open window thoracostomy (OWT).
   Methods Between January 2010 and April 2014, eight patients developed empyema following pneumonectomy for malignant diseases in our department and then underwent an OWT with subsequent VAC therapy; their cases were retrospectively studied. Each session of VAC therapy lasted 72 hours, and therapy was completed after approximately 6 sessions.
   Results OWT in six patients resulted in either decreased size or complete closure after VAC treatment. Five patients had a bronchopleural fistula (BPF), which was closed either with a tracheal stent (three patients), primary suture, or omentoplasty. The BPF in one of these patients closed during VAC therapy. The treatment failed in two patients due to the microfistula becoming obvious in one and persistence of the fistula in the other.
   Conclusion We believe that the use of VAC in the treatment of postpneumonectomy empyema is effective, except for patients with BPF.
C1 [Karapinar, Kemal; Saydam, Ozkan; Metin, Muzaffer; Erdogan, Sertan; Aker, Cemal; Arik, Burcu; Citak, Necati] Yedikule Teaching Hosp Chest Dis & Thorac Surg, Dept Thorac Surg, TR-34020 Istanbul, Turkey.
C3 Istanbul Yedikule Chest Diseases & Thoracic Surgery Training & Research
   Hospital
RP Saydam, Ö (通讯作者)，Yedikule Teaching Hosp Chest Dis & Thorac Surg, Dept Thorac Surg, TR-34020 Istanbul, Turkey.
EM ozkan.saydam@gmail.com
RI Çitak, Necati/AAE-2169-2020; Saydam, Ozkan/ODK-5790-2025; Karapınar,
   Kemal/ISU-7287-2023; Aker, Cemal/AAG-6842-2021
OI Aker, Cemal/0000-0003-1269-7442
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Badreldin AMA, 2013, THORAC CARDIOV SURG, V61, P642, DOI 10.1055/s-0032-1330226
   Banwell P, 1998, BRIT J PLAST SURG, V51, P79, DOI 10.1016/S0007-1226(98)80142-2
   Begum SSS, 2012, ANN THORAC SURG, V94, P1835, DOI 10.1016/j.athoracsur.2012.08.009
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   Matzi V, 2007, ANN THORAC SURG, V84, P1762, DOI 10.1016/j.athoracsur.2007.05.052
   Miller JI, 2004, GEN THORACIC SURG, P709
   Molnar TF, 2007, EUR J CARDIO-THORAC, V32, P422, DOI 10.1016/j.ejcts.2007.05.028
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Robinson S., 1915, COLLECTED PAPERS MAY, V7, P618
   Rocco G, 2012, EUR J CARDIO-THORAC, V41, P1069, DOI 10.1093/ejcts/ezr196
   Saadi A, 2011, ANN THORAC SURG, V91, P1582, DOI 10.1016/j.athoracsur.2011.01.018
   Shields T W., 2009, General Thoracic Surgery
   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
NR 20
TC 11
Z9 16
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD APR
PY 2016
VL 64
IS 3
BP 258
EP 262
DI 10.1055/s-0034-1390505
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA DI8GA
UT WOS:000373738300014
PM 25602849
DA 2026-07-24
ER
PT J
AU Janssen, AHJ
   Mommers, EHH
   Notter, J
   Reilingh, TSD
   Wegdam, JA
AF Janssen, A. H. J.
   Mommers, E. H. H.
   Notter, J.
   Reilingh, T. S. de Vries
   Wegdam, J. A.
TI Negative pressure wound therapy versus standard wound care on quality of
   life: a systematic review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE negative pressure wound therapy; standard wound care; quality of life
ID VACUUM-ASSISTED CLOSURE
AB Objective: Negative pressure wound therapy (NPWT) is a widely accepted treatment modality for open or infected wounds. Premature ending of NPWT occasionally occurs due to negative effects on the quality of life (QoL), however, the actual impact on QoL is unknown. The aim of this review is to analyse the effect of NPWT versus standard wound care (SWC) on QoL when used for the treatment of open or infected wounds.
   Method: A systematic literature search in a range of databases (PubMed, CINAHL, Medline, Web of Science, Science Direct Freedom Collection, SwetsWise, PSYCArticles and Infrotrac Custom Journals) using the following search terms; 'standard wound care', 'wound dressing', 'dressing', 'treatment', OR 'negative pressure wound therapy [MESH]', OR 'vacuum assisted closure' AND 'quality of life [MESH]', 'patient-satisfaction', OR 'experiences' was performed. Methodological quality was assessed using the methodological index for non-randomised studies (MINORS) checklist.
   Results: There were 42 studies identified, five matched the inclusion criteria: two randomised clinical trials (RCTs), one clinical comparative study, one exploratory prospective cohort study and one quasi experimental pilot study. Median MINORS-score was 75% (58%-96%). There were seven different questionnaires used to measure QoL or a subsidiary outcome. QoL in the NPWT group was lower in the first week, though no difference in QoL was observed thereafter.
   Conclusion: This systematic review observed that QoL improved at the end of therapy independent of which therapy was used. NPWT led to a lower QoL during the first week of treatment, possible due to aniexty, after which a similar or better QoL was reported when compared with SWC. It could be suggested that NPWT might be associated with increased anxiety.
C1 [Janssen, A. H. J.; Mommers, E. H. H.; Reilingh, T. S. de Vries; Wegdam, J. A.] Elkerliek Hosp, Dept Surg, Helmond, Netherlands.
   [Notter, J.] Birmingham City Univ, Dept Community Hlth, Birmingham, W Midlands, England.
C3 Birmingham City University
RP Janssen, AHJ (通讯作者)，Elkerliek Hosp, Dept Surg, Helmond, Netherlands.
EM sjanssen@elkerliek.nl
OI Janssen, Alexana/0000-0003-1816-0814
CR [Anonymous], COCHRANE DATABASE SY
   [Anonymous], BR J COMM NURS S8
   Bovill E, 2008, INT WOUND J, V5, P511, DOI 10.1111/j.1742-481X.2008.00437.x
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Cole-King A, 2001, PSYCHOSOM MED, V63, P216, DOI 10.1097/00006842-200103000-00004
   Desai KK, 2012, CLIN PLAST SURG, V39, P311, DOI 10.1016/j.cps.2012.05.002
   Gregor S, 2008, ARCH SURG-CHICAGO, V143, P189, DOI 10.1001/archsurg.2007.54
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50, DOI 10.1111/j.2044-8341.1959.tb00467.x
   Karatepe O, 2011, ACTA CHIR BELG, V111, P298, DOI 10.1080/00015458.2011.11680757
   Keskin M, 2008, SCAND J PLAST RECONS, V42, P202, DOI 10.1080/02844310802091586
   Mendonca D A, 2007, J Wound Care, V16, P49
   Moher D, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b2535
   Nemeth Kathleen A, 2004, Ostomy Wound Manage, V50, P34
   Ousey KJ, 2014, INT WOUND J, V11, P357, DOI 10.1111/j.1742-481X.2012.01098.x
   Peinemann F, 2008, BMC MED RES METHODOL, V8, DOI 10.1186/1471-2288-8-4
   Price P E, 2000, J Wound Care, V9, P93
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   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
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   WILLIAMS A, 1990, HEALTH POLICY, V16, P199
NR 23
TC 33
Z9 38
U1 0
U2 21
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2016
VL 25
IS 3
BP 154
EP 159
DI 10.12968/jowc.2016.25.3.154
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DJ2NZ
UT WOS:000374042900007
PM 26947696
DA 2026-07-24
ER
PT J
AU Rupert, P
AF Rupert, P.
TI Human acellular dermal wound matrix for complex diabetic wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE Wound healing; diabetic foot ulcers; acellular tissue matrix
ID REGENERATIVE TISSUE MATRIX; FOOT ULCERS; RECONSTRUCTION; MANAGEMENT;
   THERAPY; COSTS; CARE
AB Objective: Diabetic ulcers are the most common foot injuries leading to lower-extremity amputation and the most common cause of non-traumatic lower extremity amputations in the industrialised world. Approximately 85% of all diabetes-related lower-extremity amputations are preceded by foot ulcers. When foot ulcers develop despite preventive measures, early and appropriate treatment should be initiated to help reduce the burden of diabetes-related amputations. Recent advances now offer these patients a regenerative process of restoring the wound with human integument by replacing damaged or missing tissue with similar tissue rather than scar formation. The aim of this product evaluation was to test the efficacy of regenerative products on complex diabetic wounds.
   Method: Before wound intervention, the underlying comorbidities of type II diabetes mellitus and osteomyelitis were treated. In the operating room, the wounds received a sterile surgical scrub and were treated with either regenerative tissue matrix sutured over the open wounds or regenerative flowable soft tissue scaffold placed in a plantar tunnelled wound. Negative pressure wound therapy (NPWT) was applied for 10-14 days to create an environment that promotes wound healing, to secure the grafts, and to facilitate adhesion of the matrix to the wound bed.
   Results: All wounds, three in two patients, completely epithelialised without any complications at the end of the 17-week follow-up period.
   Conclusion: With the absence of complications and successful wound epithelialisation in a variety of diabetic wounds, regenerative tissue matrix products have taken the next step forward in wound healing. l Declaration of interest: PR is a consultant for KCI, an Acelity company.
C1 [Rupert, P.] Houston Methodist Hosp, Dept Surg, 6550 Fannin St SM 1661, Houston, TX 77030 USA.
C3 Houston Methodist
RP Rupert, P (通讯作者)，Houston Methodist Hosp, Dept Surg, 6550 Fannin St SM 1661, Houston, TX 77030 USA.
EM pkrupert@houstonmethodist.org
CR Berlet GC, 2006, TECH FOOT ANKLE SURG, V5, P257, DOI 10.1097/01.btf.0000235417.46038.2b
   Boulton AJM, 2004, NEW ENGL J MED, V351, P48, DOI 10.1056/NEJMcp032966
   Braun LR, 2014, AM J CLIN DERMATOL, V15, P267, DOI 10.1007/s40257-014-0081-9
   Brem H, 2004, AM J SURG, V187, p1S, DOI 10.1016/S0002-9610(03)00299-X
   Brigido SA, 2004, ORTHOPEDICS, V27, pS145
   Gupta S, 2012, INT WOUND J, V9, P8, DOI 10.1111/j.1742-481X.2012.01012.x
   Harper JR, 2007, WOUNDS, V19, P163
   Hicks CW, 2014, J VASC SURG, V60, P1247, DOI 10.1016/j.jvs.2014.05.009
   Hunt NA, 2011, PLAST RECONSTR SURG, V127, p289S, DOI 10.1097/PRS.0b013e3181fbe2a6
   Kirsner RS, 2015, INT WOUND J, V12, P646, DOI 10.1111/iwj.12185
   Pelletier EM, 2008, APPL HEALTH ECON HEA, V6, P103, DOI 10.2165/00148365-200806020-00003
   Reyzelman A, 2009, INT WOUND J, V6, P196, DOI 10.1111/j.1742-481X.2009.00585.x
   Snyder RJ, 2009, OSTOMY WOUND MANAG, V55, P28
   Stacey D Heath, 2013, Eplasty, V13, pe61
   Williams M. L., 2013, J DIABETIC FOOT COMP, V5, P55
   Zhang J, 2014, PLAST RECONSTR SURG, V134, P141, DOI 10.1097/PRS.0000000000000275
   Zhong SP, 2010, WIRES NANOMED NANOBI, V2, P510, DOI 10.1002/wnan.100
NR 17
TC 14
Z9 17
U1 0
U2 11
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2016
VL 25
IS 4
SU S
BP S17
EP S21
DI 10.12968/jowc.2016.25.Sup4.S17
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DJ2OG
UT WOS:000374043700004
PM 27068343
DA 2026-07-24
ER
PT J
AU Dwivedi, MK
   Srivastava, RN
   Bhagat, AK
   Agarwal, R
   Baghel, K
   Jain, A
   Raj, S
AF Dwivedi, M. K.
   Srivastava, R. N.
   Bhagat, A. K.
   Agarwal, R.
   Baghel, K.
   Jain, A.
   Raj, S.
TI Pressure ulcer management in paraplegic patients with a novel negative
   pressure device: a randomised controlled trial
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE pressure ulcer; negative pressure wound therapy; negative pressure
   device
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; PREVENTION; COST
AB Objective: A randomised controlled trial to compare negative pressure wound therapy (NPWT) using our innovative negative pressure device (NPD) and the standard pressure ulcer (PU) wound dressing of in traumatic paraplegia patients.
   Method: This study was conducted in the Department of Orthopaedic Surgery at King George's Medical University, Lucknow, India. Traumatic paraplegia patients with sacral pressure ulcers of stage 3 and 4 were randomised into two groups, receiving either standard wound dressings or NPWT with NPD. The outcomes monitored were length, width (surface area), depth of PU, exudates, discharge, tissue type (necrotic, slough and red granulating tissue), and cost-effectiveness during 0 to 9 weeks follow-up.
   Results: Length and width were significantly (p<0.01) decreased in NPWT group as compared with standard care group at week 9. At weeks 1, 2 and 3, depth was significantly (p<0.05) higher in NPWT group, whereas at week 9 a significant reduction (p=0.01) was observed. Exudates were significantly (p=0.001) lower in NPWT group at weeks 4 and 9. Conversion of slough into red granulation tissue was significantly higher in NPWT group (p=0.001). Discharge became significantly (p=0.001) lower in NPWT at week 2 and no discharge was observed after week 6. In all parameters, decrease was larger in NPWT group compared with standard care, which was significant for exudates type (p=0.03) and tissue type (p=0.004).
   Conclusion: Our NPD is better than standard wound care procedures and cost-effective for management of PU.
C1 [Dwivedi, M. K.; Srivastava, R. N.; Baghel, K.] King Georges Med Univ, Dept Orthopaed Surg, Lucknow, Uttar Pradesh, India.
   [Bhagat, A. K.] King Georges Med Univ, Dept Surg Gastroenterol, Lucknow, Uttar Pradesh, India.
   [Agarwal, R.] Sanjai Gandhi Post Grad Inst Med Sci SGPGIMS, Dept Plast Surg, Lucknow, Uttar Pradesh, India.
   [Jain, A.] King Georges Med Univ, Dept Microbiol, Lucknow, Uttar Pradesh, India.
   [Raj, S.] MS Ramiyah Med Coll, Bangalore, Karnataka, India.
C3 King George's Medical University; King George's Medical University;
   Sanjay Gandhi Postgraduate Institute of Medical Sciences; King George's
   Medical University
RP Srivastava, RN (通讯作者)，King Georges Med Univ, Dept Orthopaed Surg, Lucknow, Uttar Pradesh, India.
EM drrnsrivastava@yahoo.com
RI jain, amita/ABA-9223-2020
FU Council of Science and Technology, Uttar Pradesh
FX The authors are thankful to Dr. Rajendra P Mishra for his kind support.
   They are also thankful to the Council of Science and Technology, Uttar
   Pradesh, for the financial assistance.
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NR 27
TC 19
Z9 21
U1 0
U2 18
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2016
VL 25
IS 4
BP 199
EP 207
DI 10.12968/jowc.2016.25.4.199
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DJ2ON
UT WOS:000374044500005
PM 27064369
DA 2026-07-24
ER
PT J
AU Beckman, M
   Paul, J
   Neideen, T
   Weigelt, JA
AF Beckman, Marshall
   Paul, Jasmeet
   Neideen, Todd
   Weigelt, John A.
TI Role of the Open Abdomen in Critically Ill Patients
SO CRITICAL CARE CLINICS
LA English
DT Article
DE Open abdomen; Abdominal compartment syndrome; Temporary abdominal
   closure; Negative pressure wound therapy; Retroperitoneal Hemorrhage;
   Intra-abdominal infections; Damage control surgery
ID ABDOMINAL COMPARTMENT SYNDROME; PRESSURE WOUND THERAPY; DAMAGE-CONTROL;
   INTRAABDOMINAL HYPERTENSION; FASCIAL CLOSURE; TRAUMA PATIENTS;
   MANAGEMENT; GUIDELINES; DRAINAGE; VACUUM
AB An open abdomen is common used in critically ill patients to temporize permanent abdominal closure. The most common reason for leaving the abdomen open by reopening a laparotomy, not closing, or creating a fresh laparotomy is the abdominal compartment syndrome. The open abdomen technique is also used in damage control operations and intra-abdominal sepsis. Negative pressure wound therapy may be associated with better outcomes than other temporary abdominal closure techniques. The open abdomen is associated with many early and late complications, including infections, gastrointestinal fistulas, and ventral hernias. Clinicians should be vigilant regarding the development of these complications.
C1 [Beckman, Marshall; Paul, Jasmeet; Neideen, Todd; Weigelt, John A.] Med Coll Wisconsin, Dept Surg, Div Trauma Surg & Crit Care, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Weigelt, JA (通讯作者)，Med Coll Wisconsin, Dept Surg, Div Trauma Surg & Crit Care, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
EM jweigelt@mcw.edu
RI /AGQ-2011-2022
OI Paul, Jasmeet/0000-0002-4030-6624
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NR 57
TC 21
Z9 28
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0704
EI 1557-8232
J9 CRIT CARE CLIN
JI Crit. Care Clin.
PD APR
PY 2016
VL 32
IS 2
BP 255
EP +
DI 10.1016/j.ccc.2015.12.003
PG 11
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DJ7BN
UT WOS:000374367000009
PM 27016166
DA 2026-07-24
ER
PT J
AU Gathen, M
   Petri, M
   Krettek, C
   Omar, M
AF Gathen, M.
   Petri, M.
   Krettek, C.
   Omar, M.
TI Negative Pressure Wound Therapy with Instillation in the Treatment of
   Critical Wounds
SO ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
LA German
DT Article
DE VAC-therapy; negative pressure wound therapy; instillation; wound
   management; antiseptics
ID VACUUM-ASSISTED CLOSURE; POVIDONE-IODINE; IRRIGATION; INFECTIONS; SOFT;
   POLYHEXANIDE; ANTISEPTICS; MANAGEMENT
AB Background: In recent decades, negative pressure wound therapy (NPWT) has become the gold standard in the treatment of infected wounds. Negative pressure wound therapy with instillation (NPWTi) is a new development, that combines conventional NPWT with instillation of fluids.
   Objectives: The purpose of this study was to review the results of current literature on the clinical use of NPWTi in acute and chronic wounds.
   Material and Methods: A literature search was performed using Pubmed and the Cochrane Library, including articles in English and German.
   Results: The data suggest that NPWTi is a promising therapeutic option in the treatment of wounds, and applicable in various fields.
   Conclusions: NPWTi appears to be a useful adjunct in the treatment of critical wounds. However, data from prospective randomised trials to support the validity of the results are sparse.
C1 [Gathen, M.; Petri, M.; Krettek, C.; Omar, M.] Hannover Med Sch, Unfallchirurg Klin, Carl Neuberg Str 1, D-30625 Hannover, Germany.
C3 Hannover Medical School
RP Gathen, M (通讯作者)，Hannover Med Sch, Unfallchirurg Klin, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM gathen.martin@mh-hannover.de
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NR 49
TC 6
Z9 7
U1 0
U2 14
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1864-6697
EI 1864-6743
J9 Z ORTHOP UNFALLCHIR
JI Z. Orthop. Unfallchir.
PD APR
PY 2016
VL 154
IS 2
BP 122
EP 127
DI 10.1055/s-0041-109328
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA DJ8WN
UT WOS:000374494300010
PM 26844855
DA 2026-07-24
ER
PT J
AU Bach, CA
   Guilleré, L
   Yildiz, S
   Wagner, I
   Darmon, S
   Chabolle, F
AF Bach, Christine A.
   Guillere, Lia
   Yildiz, Sinasi
   Wagner, Isabelle
   Darmon, Serge
   Chabolle, Frederic
TI Comparison of negative pressure wound therapy and conventional dressing
   methods for fibula free flap donor site management in patients with head
   and neck cancer
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Article
DE negative pressure wound therapy; fibula free flap donor site head and
   neck cancer; split-thickness skin graft dressing
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; MORBIDITY;
   RECONSTRUCTION; TRIAL
AB BackgroundEvaluation of the efficacy of negative pressure wound therapy in fibula free flap donor site management in head and neck cancer.
   MethodsWe conducted a single-center retrospective study from 2007 to 2013 comparing fibula free flap donor site healing time after conventional bolster dressing or negative pressure wound therapy.
   ResultsThirteen patients were treated by conventional dressing and 16 patients were treated by negative pressure wound therapy. The mean graft loss rate was higher in the bolster group (37%) than in the negative pressure wound therapy group (19%). The mean total healing time was significantly shorter in the negative pressure wound therapy group than in the bolster group (67 days vs 163 days; p=.02).
   ConclusionThe use of negative pressure wound therapy for fibula free flap donor site management facilitates early patient mobilization, ensures better graft acceptance, and significantly decreases the healing time. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: 696-699, 2016
C1 [Bach, Christine A.; Guillere, Lia; Yildiz, Sinasi; Wagner, Isabelle; Chabolle, Frederic] Hop Foch, Serv Chirurg ORL & Cerv Faciale, Paris, France.
   [Bach, Christine A.; Guillere, Lia; Chabolle, Frederic] Univ Versailles St Quentin Yvelines, UFR Med Paris Ouest St Quentin en Yveline, Paris, France.
   [Darmon, Serge] Hop Foch, Serv Radiol, Paris, France.
C3 Hospital Foch; Universite Paris Saclay; Hospital Foch
RP Bach, CA (通讯作者)，Hop Foch, 40 Rue Worth, F-92150 Paris, France.
EM christine.bach@hopital-foch.org
CR Azzopardi EA, 2013, ANN PLAS SURG, V70, P23, DOI 10.1097/SAP.0b013e31826eab9e
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NR 14
TC 18
Z9 18
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD MAY
PY 2016
VL 38
IS 5
BP 696
EP 699
DI 10.1002/hed.23952
PG 4
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA DK1PO
UT WOS:000374685500012
PM 25522136
DA 2026-07-24
ER
PT J
AU McKanna, M
   Geraci, J
   Hall, K
   Hauan, B
   Howell, M
   Huey, T
   Lucius, A
   Mendez-Eastman, S
   Purcell, K
   Raizman, R
   Shepherd, D
   Gabriel, A
AF McKanna, Melissa
   Geraci, Jamie
   Hall, Kimberly
   Hauan, Brigitta
   Howell, Melania
   Huey, Trudy
   Lucius, Adora
   Mendez-Eastman, Susan
   Purcell, Kedrin
   Raizman, Rose
   Shepherd, Dawn
   Gabriel, Allen
TI Clinician Panel Recommendations for Use of Negative Pressure Wound
   Therapy with Instillation
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE negative pressure wound therapy; therapeutic irrigation; nursing care;
   clinical skills
AB Addition, of an instilled topical wound solution to negative pressure wound therapy (NPWT) is, designed to facilitate regular Wound cleansing to help improve outcomes of some complex wounds, but the addition of instillation to NPWT adds a level of complexity to the wound care process. The paucity of knowledge and experience with instillation may affect optimal use of this treatment modality. In an effort to address this knowledge gap, a 2-day panel meeting of nurses (N = 11) with experience using negative pressure wound therapy with instillation and dwell time (NPWTi-d) was convened to discuss their usage recommendations for managing wounds with this treatment modality in the acute care setting. Panelists reviewed available evidence and presented recommendations for managing wounds treated with NPWTi-d. Panelists agreed NPWTi-d is primarily suited to prepare surgical or nonsurgical wounds for delayed, primary closure and preparing/protecting periwound skin improves maintenance of a tight seal. Educating a team of nurses on basic NPWTi-d troubleshooting, providing a short checklist of tasks to perform every shift, and organizing needed supplies and resources may help continuity of care and prevent problems. Panelists also emphasized the importance of wound assessment and documentation and recommend educating the patient, family members; and other members of the patient-care team. Research to compare the safety, efficacy, and effectiveness of NPWTi-d and other irrigation techniques on patient outcomes and research to validate these recommendations is needed.
C1 [McKanna, Melissa] Union Hosp, 1606 N 7th St, Terre Haute, IN 47804 USA.
   [Geraci, Jamie] Bethesda North Hosp, Amelia, OH USA.
   [Hall, Kimberly] Carilion Clin, Roanoke, VA USA.
   [Hauan, Brigitta] UW Northwest Hosp, Seattle, WA USA.
   [Howell, Melania] Emanuel Med Ctr, Turlock, CA USA.
   [Huey, Trudy] Catawba Valley Med Ctr, Hickory, NC USA.
   [Lucius, Adora] UT Southwestern Med Ctr, Dallas, TX USA.
   [Mendez-Eastman, Susan] Nebraska Med, Bellevue, NE USA.
   [Purcell, Kedrin] Select Specialty Hosp, Newberry, FL USA.
   [Raizman, Rose] Shoshray Consulting, ET, Toronto, ON, Canada.
   [Shepherd, Dawn] Parkland Hlth & Hosp Syst, Dallas, TX USA.
   [Gabriel, Allen] PeaceHlth Med Grp, Dept Plast Surg, Vancouver, WA USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center
RP McKanna, M (通讯作者)，Union Hosp, 1606 N 7th St, Terre Haute, IN 47804 USA.
EM mmckanna@uhhg.org
RI Gabriel, Allen/AFK-3548-2022
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   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
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NR 16
TC 16
Z9 18
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD APR
PY 2016
SU S
BP 3
EP 14
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DK2AP
UT WOS:000374717300001
DA 2026-07-24
ER
PT J
AU Qian, SQ
   Gao, L
   Wei, Q
   Yuan, JH
AF Qian, Sheng-Qiang
   Gao, Liang
   Wei, Qiang
   Yuan, Jiuhong
TI Vacuum therapy in penile rehabilitation after radical prostatectomy:
   review of hemodynamic and antihypoxic evidence
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Review
DE oxygen; penile rehabilitation; tissue perfusion; vacuum erectile device
ID PRESSURE WOUND THERAPY; TOPICAL NEGATIVE-PRESSURE; ERECTILE DYSFUNCTION;
   BLOOD-FLOW; ASSISTED CLOSURE; DEVICE; RECOVERY; MECHANISMS; SCIENCE;
   TENSION
AB Generally, hypoxia is a normal physiological condition in the flaccid penis, which is interrupted by regular nocturnal erections in men with normal erectile function. 1 Lack of spontaneous and nocturnal erections after radical prostatectomy due to neuropraxia results in persistent hypoxia of cavernosal tissue, which leads to apoptosis and degeneration of cavernosal smooth muscle fibers. Therefore, overcoming hypoxia is believed to play a crucial role during neuropraxia. The use of a vacuum erectile device (VED) in penile rehabilitation is reportedly effective and may prevent loss of penile length. The corporal blood after VED use is increased and consists of both arterial and venous blood, as revealed by color Doppler sonography and blood gas analysis. A similar phenomenon was observed in negative pressure wound therapy (NPWT). However, NPWT employs a lower negative pressure than VED, and a hypoperfused zone, which increases in response to negative pressure adjacent to the wound edge, was observed. Nonetheless, questions regarding ideal subatmospheric pressure levels, modes of action, and therapeutic duration of VED remain unanswered. Moreover, it remains unclear whether a hypoperfused zone or PO2 gradient appears in the penis during VED therapy. To optimize a clinical VED protocol in penile rehabilitation, further research on the mechanism of VED, especially real-time PO2 measurements in different parts of the penis, should be performed.
C1 [Qian, Sheng-Qiang; Gao, Liang; Yuan, Jiuhong] Sichuan Univ, West China Hosp, Androl Lab, Chengdu 610041, Peoples R China.
   [Qian, Sheng-Qiang; Gao, Liang; Wei, Qiang; Yuan, Jiuhong] Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Peoples R China.
C3 Sichuan University; Sichuan University
RP Yuan, JH (通讯作者)，Sichuan Univ, West China Hosp, Androl Lab, Chengdu 610041, Peoples R China.; Yuan, JH (通讯作者)，Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Peoples R China.
EM jiuhongyuan2107@163.com
OI Yuan, Jiuhong/0000-0002-0991-1463
FU Natural Science Foundation of China [81170565]
FX This work was supported by the Natural Science Foundation of China (No.
   81170565).
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   Yuan J, 2010, INT J IMPOT RES, V22, P211, DOI 10.1038/ijir.2010.4
   Yuan JH, 2010, EUR UROL, V58, P773, DOI 10.1016/j.eururo.2010.07.005
   Yuan JH, 2009, J SEX MED, V6, P3247, DOI 10.1111/j.1743-6109.2009.01500.x
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NR 52
TC 21
Z9 25
U1 0
U2 8
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD MAY-JUN
PY 2016
VL 18
IS 3
BP 446
EP 451
DI 10.4103/1008-682X.159716
PG 6
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA DK4AE
UT WOS:000374857800032
PM 26289397
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yuan, XG
   Zhang, X
   Fu, YX
   Tian, XF
   Liu, Y
   Xiao, J
   Li, TW
   Qiu, L
AF Yuan, X. -g.
   Zhang, X.
   Fu, Y. -x.
   Tian, X. -f.
   Liu, Y.
   Xiao, J.
   Li, T. -w.
   Qiu, L.
TI Sequential therapy with "vacuum sealing drainage-artificial dermis
   implantation-thin partial thickness skin grafting" for deep and infected
   wound surfaces in children
SO ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
LA English
DT Article
DE Vacuum sealing drainage; Artificial dermis; Thin partial thickness skin
   grafting; Children
ID MANAGEMENT; INJURY; TRIAL
AB Objective: To evaluate the efficacy of a "vacuum sealing drainage (VSD) - artificial dermis implantation (ADI) - thin partial thickness skin grafting (TSG)" sequential therapy for deep and infected wounds in children.
   Materials and methods: Fifty-three pediatric patients with deep and infected wounds were treated with sequential VSD-ADI-TSG therapy. The efficacy of this treatment was compared with that of the surgical debridement-change dressings-thin partial thickness skin grafting previously performed on 20 patients. Survival of tissue grafts, color and flexibility, subcutaneous fullness and scar formation of the graft site were examined and compared.
   Results: The sequential therapy combined the advantages of the VSD treatment, in reducing tissue necrosis and infection on the wound surfaces and promoting the growth of granulation tissue, with the enhancement of grafting by artificial dermis. Compared with the 20 controls, skin grafted on the artificial dermis was more smooth and glossy, while the textures of the region were more elastic, and the scars were significantly lighter in Vancouver scale.
   Conclusion: The sequential VSD-ADI-TSG therapy is a simple and effective treatment for children with deep and infected wounds.
   Level of evidence: IV. (c) 2016 Published by Elsevier Masson SAS.
C1 [Yuan, X. -g.; Fu, Y. -x.; Tian, X. -f.; Liu, Y.; Xiao, J.; Li, T. -w.; Qiu, L.] Chongqing Med Univ, Childrens Hosp, Dept Burns & Plast Surg, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China.
   [Yuan, X. -g.; Zhang, X.; Fu, Y. -x.; Tian, X. -f.; Liu, Y.; Xiao, J.; Li, T. -w.; Qiu, L.] Chongqing Int Sci & Technol Cooperat Ctr Child De, Minist Educ, Key Lab Child Dev & Disorders, Key Lab Pediat Chongqing CSTC2009CA5002, Chongqing, Peoples R China.
C3 Chongqing Medical University
RP Qiu, L (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Burns & Plast Surg, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China.
EM qinlin118@126.com
RI ; zhang, xuan/HNQ-7981-2023
OI 张, 萱/0000-0002-5657-9424; 
CR [Anonymous], 2008, World Report on Child Injury Prevention
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   Yeong EK, 2013, J BURN CARE RES, V34, P161, DOI 10.1097/BCR.0b013e3182685f0a
NR 34
TC 14
Z9 20
U1 0
U2 11
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1877-0568
J9 ORTHOP TRAUMATOL-SUR
JI Orthop. Traumatol.-Surg. Res.
PD MAY
PY 2016
VL 102
IS 3
BP 369
EP 373
DI 10.1016/j.otsr.2016.01.020
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA DK8EQ
UT WOS:000375160400016
PM 27038673
DA 2026-07-24
ER
PT J
AU Hsiao, HY
   Liu, JW
   Brey, EM
   Cheng, MH
AF Hsiao, Hui-Yi
   Liu, Jia-Wei
   Brey, Eric M.
   Cheng, Ming-Huei
TI The Effects of Negative Pressure by External Tissue Expansion Device on
   Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a
   Porcine Model
SO PLOS ONE
LA English
DT Article
ID AUTOLOGOUS FAT TRANSPLANTATION; VACUUM-ASSISTED CLOSURE; BREAST
   AUGMENTATION; MURINE MODEL; ANGIOGENESIS; INFLAMMATION; LIPOSUCTION;
   MECHANISMS
AB While pre-treating a fat transplant recipient site with negative pressure has shown promise for increasing the fat survival rate, the underlying mechanisms have not been investigated, partly due to challenges related to immobilization of vacuum domes on large animal subjects. The aim of this study was to examine the effect of negative pressure treatment by External Tissue Expansion Device (ETED) on fat grating recipient sites in a porcine model. The ETED was designed to provide negative pressure on the dorsum of swine. Pressure treatment (-70 mmHg) was applied for 1 or 3 hours every other day for 10 and 20 treatments. The treated areas (3.5 cm in diameter) were harvested and examined for histological changes, vessel density, cell proliferation (Ki67) and growth factor expression (FGF-1, VEGF and PDGB-bb). The application of the ETED increased epidermis thickness even after 1-hour treatments repeated 10 times. The results of Ki67 analysis suggested that the increasing thickness was due to cell proliferation in the epidermis. There was a more than two-fold increase in the vessel density, indicating that the ETED promotes vascularization. Unexpectedly, the treatment also increased the number of hair follicles. Negative pressure provided by the ETED increases the thickness of epidermis section of tissue, cell proliferation and vessel density. The porcine model provides a better representation of the effect of the ETED on skin tissue compared to small animal models and provides an environment for studying the mechanisms underlying the clinical benefits of negative pressure treatment.
C1 [Hsiao, Hui-Yi; Liu, Jia-Wei; Cheng, Ming-Huei] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Taoyuan, Taiwan.
   [Hsiao, Hui-Yi; Liu, Jia-Wei; Cheng, Ming-Huei] Chang Gung Mem Hosp, Ctr Tissue Engn, Taoyuan, Taiwan.
   [Brey, Eric M.] IIT, Dept Biomed Engn, Chicago, IL 60616 USA.
   [Brey, Eric M.] Edward Hines Vet Adm Med Ctr, Res Serv, Hines, IL USA.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Illinois
   Institute of Technology; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Edward Hines Jr. VA Hospital
RP Cheng, MH (通讯作者)，Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Taoyuan, Taiwan.
EM minghueicheng@gmail.com
RI Cheng, Ming-Huei/AAD-8579-2019; HSIAO, HUI-YI/K-5428-2017
OI HSIAO, HUI-YI/0000-0003-3170-2112
FU Ministry of Science and Technology;  [NMRPG3C6193]
FX The study is supported by Ministry of Science and Technology
   (www.most.gov.tw). The financial support is founded with the grant
   number NMRPG3C6193. MHC was the PI on this funding support. The funder
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 28
TC 13
Z9 15
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 29
PY 2016
VL 11
IS 4
AR e0154328
DI 10.1371/journal.pone.0154328
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DK8XM
UT WOS:000375212600027
PM 27128731
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Assirati, G
   Serra, V
   Tarantino, G
   Aldrovandi, S
   Ballarin, R
   Magistri, P
   De Ruvo, N
   Di Benedetto, F
AF Assirati, G.
   Serra, V.
   Tarantino, G.
   Aldrovandi, S.
   Ballarin, R.
   Magistri, P.
   De Ruvo, N.
   Di Benedetto, F.
TI Vacuum-Assisted Closure Therapy in Patients Undergoing Liver
   Transplantation With Necessity to Maintain Open Abdomen
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article
ID PRESSURE WOUND THERAPY; NEGATIVE-PRESSURE; MANAGEMENT
AB Background. Negative-pressure wound therapy (NPWT) has been recognized as a valid method of temporary abdominal closure. The role of open abdomen (OA) in the management of abdominal sepsis has been a controversial issue. Recent experimental and clinical studies have indicated that vacuum-assisted closure (VAC) is associated with superior outcomes in the treatment of OA conditions, but sufficient proof of efficacy and effectiveness is lacking.
   Methods. We enrolled in this observational study all patients who had undergone liver transplantation (LT) for all causes between 2007 and 2014 in whom we needed to use VAC therapy, describing the pathology that led to the complication, length of hospitalization, graft survival, microbial identifications, and causes of death.
   Results. We enrolled 11 patients-6 men (55%) and 5 women (45%), from 41.92 to 64.96 years old (mean, 57.62 +/- 6.56 years) -who went to LT for different pathologies. The mean hospital stay was 56.72 +/- 36.40 days (range, 8-133 days). Graft survival was 35.65 +/- 31.61 months (range, 1.51-89.19 months). Six of 11 patients died (55%) of different causes; in particular, 4 patients died 1 to 3 months after the procedures that led to the condition of OA for septic shock and subsequent multi-organ failure.
   Conclusions. Complications related to the use of NPWT, such as painful management and bleeding, are rare and mild when the device is used properly. Although studies are needed to verify the real cost/benefit ratio in this application of VAC therapy, we consider it a useful means to treat the OA condition.
C1 [Assirati, G.; Serra, V.; Tarantino, G.; Aldrovandi, S.; Ballarin, R.; Magistri, P.; De Ruvo, N.; Di Benedetto, F.] Univ Modena & Reggio Emilia, Hepatopancreatobiliary Surg & Liver Transplanta, Modena, Italy.
C3 Universita di Modena e Reggio Emilia
RP Di Benedetto, F (通讯作者)，AOU Policlin Modena, Via Pozzo 71, I-41100 Modena, Italy.
EM fabrizio.dibenedetto@unimore.it
RI Tarantino, Giuseppe/AAD-1064-2022; Magistri, Paolo/C-4425-2016; Di
   Benedetto, Fabrizio/B-8388-2015
OI Tarantino, Giuseppe/0000-0001-8102-6293; Magistri,
   Paolo/0000-0001-8326-069X; 
CR Amin AI, 2009, WORLD J GASTROENTERO, V15, P3394, DOI 10.3748/wjg.15.3394
   [Anonymous], ICU DIR
   [Anonymous], GASTROENTEROL RES PR
   Ashby RL, 2012, TRIALS, V13, DOI 10.1186/1745-6215-13-119
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   Quyn AJ, 2012, COLORECTAL DIS, V14, pE429, DOI 10.1111/j.1463-1318.2012.03045.x
   Rahmanian-Schwarz A, 2012, BURNS, V38, P573, DOI 10.1016/j.burns.2011.10.010
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NR 15
TC 9
Z9 10
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD MAR
PY 2016
VL 48
IS 2
BP 383
EP 385
DI 10.1016/j.transproceed.2015.12.037
PG 3
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Surgery; Transplantation
GA DK9HA
UT WOS:000375240300024
PM 27109961
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Coakley, DN
   Shaikh, FM
   O'Sullivan, K
   Kavanagh, EG
   Grace, PA
   McGloughlin, TM
AF Coakley, Daniel N.
   Shaikh, Faisal M.
   O'Sullivan, Kathleen
   Kavanagh, Eamon G.
   Grace, Pierce A.
   McGloughlin, Tim M.
TI Design and evaluation of a novel subatmospheric pressure bioreactor for
   the preconditioning of tissue-engineered vascular constructs
SO INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Bioreactor; Tissue-engineering; Biomaterials; Vascular sugery
ID WOUND THERAPY; SHEAR-STRESS; MECHANICAL STRAIN; PROLIFERATION; CELLS
AB Purpose: The pre-conditioning of tissue-engineered vascular scaffolds with mechanical stimuli is being recognised as an essential step in producing a functional vascular construct. In this study we design and evaluate a novel bioreactor, which exerts a mechanical strain on developing vascular scaffolds via subatmospheric pressure.
   Methods: We design and construct a bioreactor, which exerts subatmospheric pressure via a vacuum assisted closure unit. Vascular scaffolds seeded with human umbilical endothelial cells were evaluated for structural integrity, microbial contamination, cellular viability, von Willebrand factor (VWF) production, cell proliferation and morphology under a range of subatmospheric pressures (75-200mmHg).
   Results: The bioreactor produced sustained subatmospheric pressures, which exerted a mechanical strain on the vascular scaffold. No microbial contamination was found during the study. The structural integrity of the vascular construct was maintained. There was no difference in cellular viability between control or subatmospheric pressure groups (p = 0.817). Cells continued to produce VWF under a range of subatmospheric pressures. Cells subjected to subatmospheric pressures of 125mmHg and 200mmHg exhibited higher levels of growth than cells in atmospheric pressure at 24 (p = 0.016) and 48 hour (p = 0.001). Negative pressure affected cellular morphology, which were more organised, elongated and expanded when exposed to subatmospheric pressure.
   Conclusions: We have constructed and validated a novel subatmospheric bioreactor. The bioreactor maintained a continuous subatmospheric pressure to the vascular scaffolds in a stable, sterile and constant environment. The bioreactor exerted a strain on the vascular sheets, which was shown to alter cellular morphology and enhance cellular proliferation.
C1 [Coakley, Daniel N.; Shaikh, Faisal M.; Kavanagh, Eamon G.; Grace, Pierce A.] Univ Hosp Limerick, Dept Vasc Surg, Limerick, Ireland.
   [O'Sullivan, Kathleen] Natl Univ Ireland Univ Coll Cork, Sch Math Sci, Stat Consultancy Unit, Cork, Ireland.
   [McGloughlin, Tim M.] Khalifa Univ Sci Technol & Res KUSTAR, Dept Biomed Engn, Abu Dhabi, U Arab Emirates.
C3 University of Limerick; University College Cork; Khalifa University of
   Science & Technology
RP Coakley, DN (通讯作者)，Univ Hosp Limerick, Dept Vasc Surg, Limerick, Ireland.
EM drdanielcoakley@gmail.com
RI ; McGloughlin, Tim/G-9526-2015; Shaikh, Faisal/LRC-9231-2024
OI Coakley, Daniel/0000-0003-1262-2782; McGloughlin,
   Tim/0000-0003-3519-8988; 
FU Royal College of Surgeons Ireland Research Grant [311257]
FX The work was funded by the Royal College of Surgeons Ireland Research
   Grant (Ref. 311257).
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NR 29
TC 2
Z9 2
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0391-3988
EI 1724-6040
J9 INT J ARTIF ORGANS
JI Int. J. Artif. Organs
PD FEB
PY 2016
VL 39
IS 2
BP 77
EP 83
DI 10.5301/ijao.5000475
PG 7
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA DL1HR
UT WOS:000375383700006
PM 26953899
DA 2026-07-24
ER
PT J
AU Cooper, HJ
   Bas, MA
AF Cooper, H. John
   Bas, Marcel A.
TI Closed-Incision Negative-Pressure Therapy Versus Antimicrobial Dressings
   After Revision Hip and Knee Surgery: A Comparative Study
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE closed-incision negative-pressure therapy; surgical site infections;
   prevention; hip revision; knee revision; quality improvement
ID TOTAL JOINT ARTHROPLASTY; SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED
   CLOSURE; WOUND THERAPY; UNITED-STATES; HIGH-RISK; COST-EFFECTIVENESS;
   PREVENTION; MANAGEMENT; FRACTURES
AB Background: This study evaluates the efficacy of closed-incision negative-pressure therapy (ciNPT) in decreasing wound complications and surgical site infections (SSIs) after revision hip and knee surgery.
   Methods: A retrospective quality improvement analysis of 138 consecutive revision hip and knee operations performed by a single surgeon over a 34-month period was performed. ciNPT was used selectively in higher-risk patients with multiple risk factors for SSIs over the last 15 months of the study period. Rates of wound complications, SSIs, and reoperation were compared with patients treated with a sterile antimicrobial dressing.
   Results: Antimicrobial dressings were used in 108 patients, whereas ciNPT was used in 30 patients. Patients treated with ciNPT developed fewer overall wound complications (6.7% vs 26.9%, P = .024) and fewer total SSIs (3.3% vs 18.5%, P = .045) than patients treated with antimicrobial dressings. In addition, there were trends toward a lower rate of superficial wound dehiscence (6.7% vs 19.4%, P = .163), fewer deep periprosthetic joint infections (0.0% vs 9.3%, P = .118), and fewer reoperations (3.3% vs 13.0%, P = .191) among patients treated with ciNPT.
   Conclusion: Our findings suggest that ciNPT may decrease wound complications and SSIs in patients undergoing revision hip and knee surgery. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Cooper, H. John; Bas, Marcel A.] Lenox Hill Hosp, North Shore LIJ Hlth Syst, Dept Orthopaed Surg, Div Adult Reconstruct, New York, NY 10075 USA.
C3 Northwell Health
RP Cooper, HJ (通讯作者)，Lenox Hill Hosp, Dept Orthopaed Surg, 130 East 77th St,11th Floor, New York, NY 10075 USA.
RI Cooper, Herbert/H-3488-2019
OI Cooper, Herbert/0000-0002-9272-668X
CR Adelani MA, 2014, BONE JOINT J, V96B, P619, DOI 10.1302/0301-620X.96B5.33479
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NR 46
TC 79
Z9 88
U1 0
U2 12
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD MAY
PY 2016
VL 31
IS 5
BP 1047
EP 1052
DI 10.1016/j.arth.2015.11.010
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA DL2KK
UT WOS:000375463400024
PM 26712346
DA 2026-07-24
ER
PT J
AU Krticka, M
   Ira, D
   Nekuda, V
   Svancara, J
   Masek, M
AF Krticka, M.
   Ira, D.
   Nekuda, V.
   Svancara, J.
   Masek, M.
TI Effect of Negative Pressure Wound Therapy on Infectious Complications in
   Grade III Open Fractures
SO ACTA CHIRURGIAE ORTHOPAEDICAE ET TRAUMATOLOGIAE CECHOSLOVACA
LA Czech
DT Article
DE open fracture; negative pressure wound therapy; continual wound lavage;
   infection
ID VACUUM-ASSISTED CLOSURE; OPEN TIBIAL FRACTURES
AB PURPOSE OF THE STUDY
   Grade III open fractures are associated with infectious complications in 25-66% of injuries. Negative pressure wound therapy (NPWT) applied to an injured soft tissue coverage provides an impermeable barrier between the injured structures and the external environment, in addition to early secretion draining and a positive effect on the site of application. All this also prevents secondary bacterial contamination.
   The objective of the study was to compare the results of treatment methods in view of infectious complications in patients with soft tissue injury in grade-III open fractures managed either by NPWT and primary closure or by covering with combined dressing fabric (COM) in combination with continual wound lavage.
   MATERIAL AND METHODS
   This retrospective study comprised 77 patients with 80 grade III open fractures treated in the years 2008-2012; of these, 39 patients with 41 fractures met the inclusion criteria and were finally evaluated. The patients were divided into two groups. The control group included 19 patients with 20 fractures treated by the standard surgical procedure using stabilisation with an external fixator or intramedullary nail, thorough soft tissue debridement, continual wound lavage and suture of skin lesions or using a primary coverage of the defect with COM. The trial group consisted of 20 patients with 21 fractures treated according to the same principle, but NPWT was applied to injured soft tissue coverage first and skin suture or any other type of skin defect coverage was carried out when the healing process was good and bacteriological findings were negative. The results of both methods were evaluated based on the following criteria: development of superficial or deep infection in the wound, interval to negative bacteriological findings and osteomyelitis rate. The results were analysed by Fisher's exact test and the Man Whitney U test.
   RESULTS
   Infectious complications were recorded in a total of 15 (37%) fractures: 11 (55%) in the control group and four (19.1%) in the trial group (p = 0.025). Recurrent infection was observed in five control group fractures (25%) and in none of the trial group fractures (p = 0.021). Osteomyelitis was found only in two control group fractures. The average interval before negative bacteriological results were obtained was 22 days in the control group and 12 days in the trial group (p = 0.001).
   DISCUSSION
   The NPWT use as a temporary coverage of soft tissue defects in open fractures results in a significant reduction of infectious complications, as shown by many relevant studies including this study. In comparison with Gopal's "fix and flap" concept, the NPWT in our patient group had slightly higher incidence of infectious complications (15.4% versus 19.1%). However, these results can be achieved only if a specialist in reconstructive surgery and appropriate technical facilities are readily available. If this is not possible, then the NPWT, in comparison with conventional methods, provides the best possible way of temporary protection for an injured soft tissue coverage.
   CONCLUSIONS
   Application of NPWT within the primary treatment of injured soft tissue coverage in grade III open fractures results in a statistically significant reduction of bacterial contamination at the site of injury, as well as a reduction of the subsequent incidence of infectious complications. Primary application of NPWT also significantly reduced the risk of recurrent infection.
C1 [Krticka, M.; Ira, D.; Nekuda, V.; Masek, M.] FN Brno, Klin Urazove Chirurg, Jihlayska 20, Brno 62500, Czech Republic.
   [Krticka, M.; Ira, D.; Nekuda, V.; Masek, M.] Masarykovy Univ Brno, LF, Brno, Czech Republic.
   [Svancara, J.] Masarykovy Univ Brno, Lekarske Fak, Inst Biostat & Anal, Brno, Czech Republic.
   [Svancara, J.] Masarykovy Univ Brno, Prirodovedecke Fak, Brno, Czech Republic.
C3 University Hospital Brno; Masaryk University; Institute of Biostatistics
   & Analyses; Masaryk University; Masaryk University
RP Krticka, M (通讯作者)，FN Brno, Klin Urazove Chirurg, Jihlayska 20, Brno 62500, Czech Republic.
EM milan.krticka@fnbrno.cz
RI Švancara, Jan/G-5285-2017; Ira, Daniel/ABD-7164-2020; Krtička,
   Milan/ABE-1428-2020; Nekuda, Vladimír/ABF-7187-2020
OI Švancara, Jan/0000-0003-1692-3339; Ira, Daniel/0000-0002-7332-9830;
   Krtička, Milan/0000-0002-7101-1896; Masek, Michal/0000-0001-9368-8825;
   Nekuda, Vladimír/0000-0003-0644-8378
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NR 24
TC 7
Z9 7
U1 0
U2 12
PU GALEN SRO
PI PRAGUE 5
PA NA BELIDLE 34, PRAGUE 5, 150 00, CZECH REPUBLIC
SN 0001-5415
J9 ACTA CHIR ORTHOP TR
JI Acta Chir. Orthop. Traumatol. Cechoslov.
PD APR
PY 2016
VL 83
IS 2
BP 117
EP 122
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA DL6EQ
UT WOS:000375732900008
PM 27167417
DA 2026-07-24
ER
PT J
AU Bleszynski, MS
   Chan, T
   Buczkowski, AK
AF Bleszynski, Michael S.
   Chan, Tiffany
   Buczkowski, Andrzej K.
TI Open abdomen with negative pressure device vs primary abdominal closure
   for the management of surgical abdominal sepsis: a retrospective review
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Abdominal sepsis; Open abdomen; Vacuum assisted closure; On-demand
   laparotomy; APACHE-1V
ID DAMAGE CONTROL; PLANNED RELAPAROTOMY; HOSPITAL MORTALITY; SEVERE
   PERITONITIS; ACUTE PHYSIOLOGY; ON-DEMAND; INFECTION; METAANALYSIS;
   SURGERY; THERAPY
AB BACKGROUND: Open abdomen with temporary abdominal closure remains a controversial management strategy for surgical abdominal sepsis compared with primary abdominal closure (PAC) and on-demand laparotomy. The primary objective was to compare mortality between PAC and open abdomen with vacuum assisted closure (VAC).
   METHODS: Retrospective review of a tertiary center intensive care unit database (2006 to 2010) including suspected/diagnosed severe abdominal sepsis/septic shock requiring source control laparotomy. Groups were categorized according to closure method at index source control laparotomy. APACHE-IV was used as a measure of disease severity.
   RESULTS: Of 211 patients, 75 PAC and 136 VAC cases were included. Controlling for disease severity, adjusted odds ratio of mortality for VAC was .41 95% confidence interval (.21, .81; P = .01) compared with PAC. PAC and VAC APACHE-1V predicted mortality rate were both 45%. VAC mortality was lower than PAC (22.8% vs 38.6%; P = .012).
   CONCLUSIONS: Open abdomen with VAC is associated with significantly improved survival compared with PAC in abdominal sepsis requiring laparotomy. (C) 2016 The Authors. Published by Elsevier Inc.
C1 [Bleszynski, Michael S.; Chan, Tiffany; Buczkowski, Andrzej K.] Univ British Columbia, Vancouver Gen Hosp, Dept Gen Surg, Div Gen Surg, Rm 3100 Jim Pattison Pavill North, Vancouver, BC V5Z 1M9, Canada.
C3 University of British Columbia
RP Bleszynski, MS (通讯作者)，Univ British Columbia, Vancouver Gen Hosp, Dept Gen Surg, Div Gen Surg, Rm 3100 Jim Pattison Pavill North, Vancouver, BC V5Z 1M9, Canada.
EM mbleszyn@gmail.com
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NR 27
TC 25
Z9 35
U1 0
U2 5
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2016
VL 211
IS 5
BP 926
EP 931
DI 10.1016/j.amjsurg.2016.01.012
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DL7BR
UT WOS:000375795000026
PM 27020900
OA hybrid
DA 2026-07-24
ER
PT J
AU Thorbjornsen, K
   Gidlund, KD
   Björck, M
   Kragsterman, B
   Wanhainen, A
AF Thorbjornsen, K.
   Gidlund, K. Djavani
   Bjorck, M.
   Kragsterman, B.
   Wanhainen, A.
TI Editor's Choice - Long-term Outcome After EndoVAC Hybrid Repair of
   Infected Vascular Reconstructions
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE Access site infection; Hybrid technique; Negative pressure wound
   therapy; Stent graft; Vacuum assisted wound closure; Vascular graft
   infection
ID ASSISTED WOUND CLOSURE; DACRON PATCH INFECTION; OF-THE-LITERATURE;
   PROSTHETIC GRAFT INFECTIONS; MYCOTIC AORTIC-ANEURYSMS; MUSCLE FLAP
   COVERAGE; CAROTID-ENDARTERECTOMY; SYNTHETIC GRAFTS; GROIN INFECTIONS;
   MANAGEMENT
AB Objective/Background: Vascular graft infection is a serious and challenging complication. In situations when neither traditional radical surgery nor conservative negative pressure wound therapy (VAC) alone, are considered feasible or safe, for example due to bleeding, adverse anatomy, or severe comorbidity, a novel hybrid procedure was developed. The EndoVAC technique consists of (i) relining of the infected reconstruction with a stent graft; (ii) surgical revision (without clamping the reconstruction); and (iii) VAC therapy, to permit granulation and secondary delayed healing, and long-term antibiotic treatment. The aim of the study is to report long-term follow up data of this new treatment modality.
   Methods: From November 2007 to June 2015, 17 EndoVAC procedures were performed in 16 patients (eight men, aged 16-91 years): six infected carotid patches after carotid endarterectomy, three infected neck deviations, two infected femoro-popliteal bypasses, three infected patches after femoral thrombo-endarterectomy, and two infected vascular accesses. Surveillance was performed routinely every 3-6 months and included clinical examination, hematologic tests, duplex ultrasonography, and imaging techniques, including 18F-fluorodeoxyglucose positron emission tomography/computed tomography.
   Results: Primary technical success rate was 100%. Antibiotics were prescribed for a median of 3 months (range 1-20 months). The median duration of VAC treatment was 14 days (range 9-57 days). Complications included early, transient stroke (n = 1), temporary hypoglossal palsy (n = 1), and late, asymptomatic occluded bypasses (n = 2), stent graft thrombosis (n = 1), and moderate carotid stenosis (n = 1). After a median of 5 years (range 1-90 months) of follow up, all patients had healed graft infections with no recurrence was observed. Eight patients died as a result of severe comorbidities, unrelated to the infection or hybrid procedure, 1 month 7 years after treatment.
   Conclusion: The EndoVAC technique is an alternative, less invasive, option for treatment of infected vascular reconstructions in selected cases, when neither traditional radical surgery, nor conservative simple negative pressure wound therapy are considered feasible or safe. The exact indications for this alternative hybrid treatment need to be established. (C) 2016 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Thorbjornsen, K.; Gidlund, K. Djavani; Bjorck, M.; Kragsterman, B.; Wanhainen, A.] Uppsala Univ, Vasc Surg Sect, Dept Surg Sci, Uppsala, Sweden.
   [Thorbjornsen, K.; Gidlund, K. Djavani] Uppsala Univ, Cty Council Gavleborg, Ctr Res & Dev, Gavle, Sweden.
C3 Uppsala University; Uppsala University
RP Wanhainen, A (通讯作者)，Uppsala Univ, Vasc Surg Sect, Dept Surg Sci, Uppsala, Sweden.
EM anders.wanhainen@surgsci.uu.se
OI Thorbjørnsen, Knut/0000-0003-4404-5406
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NR 41
TC 21
Z9 24
U1 0
U2 1
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD MAY
PY 2016
VL 51
IS 5
BP 724
EP 732
DI 10.1016/j.ejvs.2016.01.011
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA DM2YI
UT WOS:000376213600023
PM 26944600
DA 2026-07-24
ER
PT J
AU Willy, C
   Stichling, M
   Müller, M
   Gatzer, R
   Kramer, A
   Back, DA
   Vogt, D
AF Willy, C.
   Stichling, M.
   Mueller, M.
   Gatzer, R.
   Kramer, A.
   Back, D. A.
   Vogt, D.
TI Acute therapeutic measures for limb salvage Part 2. Debridement, lavage
   techniques and anti-infectious strategies
SO UNFALLCHIRURG
LA German
DT Article
DE Therapeutic irrigation; Wound infection; Biofilms; Negative pressure
   wound therapy; Vacuum instillation therapy; Open fractures
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTION; PRESSURE WOUND
   THERAPY; OPEN TIBIA FRACTURES; PULSE-LAVAGE; IN-VITRO; IRRIGATION;
   BIOFILM; MANAGEMENT; FEMUR
AB The quality of the primary care of Gustilo-Anderson (GA) type IIIB and IIIC extremity injuries is crucial to the success of the limb salvage procedure. This article provides a compilation of consistent, but often controversially discussed aspects of initial debridement, modern techniques of lavage and wound closure, in addition to current issues on the application of antibiotics and antiseptics, based on our own experiences and the latest literature. The following points should be stressed. Severe extremity injuries with gross contamination (GA IIIA, B, and C) will still be associated with an infection rate of up to 60 %. The initial debridement should be performed as soon as an experienced trauma surgeon is available. Tissue that is definitely avital will have to be removed, whereas traumatized but potentially surviving tissue will have to be re-evaluated during a second-look operation after 36-48 h. Given a high enough level of contamination, biofilms will form after as few as 6 h. The perioperative antibiotic prophylaxis has to be initiated early and should be continued for at least 24 h (GA I/II) or up to 5 days (GA III). In cases of bacterial contamination, wound irrigation will be useful with additives such as polyhexanide, octenidine or superoxidized water. Rinsing of the wound should be performed with 3-9 L and only slight manual pressure (no jet lavage). The definitive primary closure of a wound should be achieved in the initial operation, but only in the case of certain "decontamination" and overall vitality of the wound (GA I and II). In the presence of high-grade injuries, a temporary vacuum sealing technique can be used until the earliest possible definitive plastic surgical wound closure.
C1 [Willy, C.; Vogt, D.] Bundeswehrkrankenhaus Berlin, Exzellenz Zentrum Versorgung Verwundeten Kriegs &, Forsch & Behandlungszentrum Rekonstrukt Defektwun, Abt Unfallchirurg & Orthopadie,Septisch Rekonstru, Scharnhorststr 13, D-10115 Berlin, Germany.
   [Stichling, M.] Bundeswehrkrankenhaus Berlin, Sekt Gefass & Thoraxchirurg, Abt Unfallchirurg & Orthopadie, Septisch Rekonstrukt Chirurg, D-10115 Berlin, Germany.
   [Mueller, M.; Gatzer, R.] Bundeswehr Kiel Berlin, Zent Inst Sanitatsdienstes, Lab Grp Med Mikrobiol, Abt 1, Berlin, Germany.
   [Kramer, A.] Univ Med Greifswald, Inst Hyg & Umweltmed, Greifswald, Germany.
   [Back, D. A.] Bundeswehrkrankenhaus Berlin, Abt Allgemein & Viszeralchirurg, D-10115 Berlin, Germany.
C3 Universitat Greifswald; Greifswald Medical School
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Berlin, Exzellenz Zentrum Versorgung Verwundeten Kriegs &, Forsch & Behandlungszentrum Rekonstrukt Defektwun, Abt Unfallchirurg & Orthopadie,Septisch Rekonstru, Scharnhorststr 13, D-10115 Berlin, Germany.
EM christianwilly@bundeswehr.org
RI /AAJ-3174-2021
OI Back, David Alexander/0000-0001-7552-7753
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NR 80
TC 7
Z9 9
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD MAY
PY 2016
VL 119
IS 5
BP 388
EP +
DI 10.1007/s00113-016-0178-0
PG 11
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA DM5SB
UT WOS:000376409200007
PM 27160730
DA 2026-07-24
ER
PT J
AU Kachala, SS
   D'Souza, DM
   Teixeira-Johnson, L
   Murthy, SC
   Raja, S
   Blackstone, EH
   Raymond, DP
AF Kachala, Stefan S.
   D'Souza, Desmond M.
   Teixeira-Johnson, Lucileia
   Murthy, Sudish C.
   Raja, Siva
   Blackstone, Eugene H.
   Raymond, Daniel P.
TI Surgical Management of Sternoclavicular Joint Infections
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID ARTHRITIS
AB Background. Infections of the sternoclavicular joint (SCJ) respond poorly to nonoperative management and typically require resection. We examined presenting characteristics and outcomes after surgical management of SCJ infections, reviewing a 20-year single-institution experience.
   Methods. From January 1992 to December 2012, 40 patients (age, 57 +/- 12 years; 70% male) underwent resection of an infected SCJ. Sternal infections after cardiac surgery were excluded. Clinical features, microbiology, recurrence, survival, and functional impairment were assessed. Infection was documented by the surgeon, and supported by tissue culture. Clinical presentation and treatment course were obtained by review of medical records. The functional assessment was determined by phone interviews using the validated QuickDASH outcome measure. Mortality data were gathered from the medical record.
   Results. Pain was the presenting symptom in 93% of patients. Staphylococcal species were isolated in 73% of tissue specimens. Fifteen patients (37%) underwent primary closure and 25 patients (63%) underwent closure by secondary intention with application of negative-pressure wound therapy. There were four recurrences (10%), one after primary closure and three in the secondary intention group. No deaths occurred within 30 days of operation, and 5-year survival was 67%. Functional assessment using the QuickDASH outcome measure revealed minimal loss in upper extremity function after the procedure (preoperative score, 10 +/- 3; postoperative score, 19 +/- 6.8; n = 11). There was no difference in functional outcome comparing primary closure versus secondary intention (19 +/- 4.4 versus 20 +/- 8.2; p = 0.64).
   Conclusions. Septic arthritis of the SCJ is routinely managed surgically at many centers. We report that primary closure with a muscle flap can achieve similar outcomes to secondary intention in selected patients. Furthermore, patients experienced minimal functional impairment at long-term follow-up. (C) 2016 by The Society of Thoracic Surgeons
C1 Cleveland Clin, Thorac & Cardiovasc Surg, Cleveland, OH 44195 USA.
   Cleveland Clin, Dept Infect Dis, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation
RP Raymond, DP (通讯作者)，Cleveland Clin, Mail Code J4-1,9500 Euclid Ave, Cleveland, OH 44195 USA.
EM raymond3@ccf.org
OI Blackstone, Eugene/0000-0001-9839-3567; D'Souza, Desmond
   M/0000-0002-7342-3464
CR [Anonymous], 2011, The DASH and QuickDASH Outcome Measure Users Manual
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NR 12
TC 32
Z9 41
U1 1
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD JUN
PY 2016
VL 101
IS 6
BP 2155
EP 2160
DI 10.1016/j.athoracsur.2016.01.054
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA DM6ZW
UT WOS:000376502600024
PM 27083249
OA Bronze
DA 2026-07-24
ER
PT J
AU Thiels, CA
   Aho, JM
   Naik, ND
   Zielinski, MD
   Schiller, HJ
   Morris, DS
   Kim, BD
AF Thiels, Cornelius A.
   Aho, Johnathon M.
   Naik, Nimesh D.
   Zielinski, Martin D.
   Schiller, Henry J.
   Morris, David S.
   Kim, Brian D.
TI Infected hardware after surgical stabilization of rib fractures:
   Outcomes and management experience
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Flail chest; hardware infection; rib fracture; SSRF; surgical
   stabilization
ID ANTIBIOTIC-THERAPY; CHEST; OSTEOMYELITIS; DISABILITY; INJURIES; REPAIR;
   TIBIA; PAIN
AB BACKGROUND: Surgical stabilization of rib fracture (SSRF) is increasingly used for treatment of rib fractures. There are few data on the incidence, risk factors, outcomes, and optimal management strategy for hardware infection in these patients. We aimed to develop and propose a management algorithm to help others treat this potentially morbid complication.
   METHODS: We retrospectively searched a prospectively collected rib fracture database for the records of all patients who underwent SSRF from August 2009 through March 2014 at our institution. We then analyzed for the subsequent development of hardware infection among these patients. Standard descriptive analyses were performed.
   RESULTS: Among 122 patients who underwent SSRF, most (73%) were men; the mean (SD) age was 59.5 (16.4) years, and median (interquartile range [IQR]) Injury Severity Score was 17 (13Y22). The median number of rib fractures was 7 (5-9) and 48% of the patients had flail chest. Mortality at 30 days was 0.8%. Five patients (4.1%) had a hardware infection on mean (SD) postoperative day 12.0 (6.6). Median Injury Severity Score (17 [range, 13-42]) and hospital length of stay (9 days [6-37 days]) in these patients were similar to the values for those without infection (17 days [range, 13Y22 days] and 9 days [6-12 days], respectively). Patients with infection underwent a median (IQR) of 2 (range, 2-3) additional operations, which included wound debridement (n = 5), negative-pressure wound therapy (n = 3), and antibiotic beads (n = 4). Hardware was removed in 3 patients at 140, 190, and 192 days after index operation. Cultures grew only gram-positive organisms. No patients required reintervention after hardware removal, and all achieved bony union and were taking no narcotics or antibiotics at the latest follow-up.
   CONCLUSIONS: Although uncommon, hardware infection after SSRF carries considerable morbidity. With the use of an aggressive multimodal management strategy, however, bony union and favorable long-term outcomes can be achieved. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Thiels, Cornelius A.; Aho, Johnathon M.; Naik, Nimesh D.; Zielinski, Martin D.; Schiller, Henry J.; Morris, David S.; Kim, Brian D.] Mayo Clin, Dept Surg, 200 First St SW, Rochester, MN 55905 USA.
   [Thiels, Cornelius A.] Mayo Clin, Robert D & Patricia E Kern Ctr Sci Hlth Care Deli, Rochester, MN 55905 USA.
   [Aho, Johnathon M.] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Kim, BD (通讯作者)，Mayo Clin, Dept Surg, 200 First St SW, Rochester, MN 55905 USA.
EM kim.brian@mayo.edu
RI Morris, David/AAW-1940-2021
OI Thiels, Cornelius/0000-0003-3654-8601
FU Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of
   Health Care Delivery; NHLBI from the National Heart, Lung, and Blood
   Institute a component of the National Institutes of Health [T32
   HL105355]; National Heart Lung and Blood Institute [T32HL105355] Funding
   Source: NIH RePORTER
FX Support was provided by the Mayo Clinic Robert D. and Patricia E. Kern
   Center for the Science of Health Care Delivery (Thiels) and by the NHLBI
   grant T32 HL105355 from the National Heart, Lung, and Blood Institute, a
   component of the National Institutes of Health (Aho).
CR Berbari EF, 1998, CLIN INFECT DIS, V27, P1247, DOI 10.1086/514991
   Craig J, 2014, INT ORTHOP, V38, P1025, DOI 10.1007/s00264-014-2293-2
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NR 20
TC 36
Z9 43
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD MAY
PY 2016
VL 80
IS 5
BP 819
EP 823
DI 10.1097/TA.0000000000001005
PG 5
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA DM9ZB
UT WOS:000376723100027
PM 26891160
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Seternes, A
   Fasting, S
   Klepstad, P
   Mo, S
   Dahl, T
   Bjorck, M
   Wibe, A
AF Seternes, Arne
   Fasting, Sigurd
   Klepstad, Pal
   Mo, Skule
   Dahl, Torbjorn
   Bjorck, Martin
   Wibe, Arne
TI Bedside dressing changes for open abdomen in the intensive care unit is
   safe and time and staff efficient
SO CRITICAL CARE
LA English
DT Article
DE Abdominal compartment syndrome; Open abdomen; Dressing changes;
   Infections; Intensive care; Resources; Health economy
ID CRITICALLY-ILL PATIENTS; ABDOMINAL COMPARTMENT SYNDROME; MEDIATED
   FASCIAL TRACTION; INTRAHOSPITAL TRANSPORT; OPERATING-ROOM;
   INTRAABDOMINAL HYPERTENSION; PERCUTANEOUS TRACHEOSTOMY; TRAUMA PATIENTS;
   LAPAROTOMY; MANAGEMENT
AB Background: Patients with an open abdomen (OA) treated with temporary abdominal closure (TAC) need multiple surgical procedures throughout the hospital stay with repeated changes of the vacuum-assisted closure device (VAC changes). The aim of this study was to examine if using the intensive care unit (ICU) for dressing changes in OA patients was safe regarding bloodstream infections (BSI) and survival. Secondary aims were to evaluate saved time, personnel, and costs.
   Methods: All patients treated with OA in the ICU from October 2006 to June 2014 were included. Data were retrospectively obtained from registered procedure codes, clinical and administrative patients' records and the OR, ICU, anesthesia and microbiology databases. Outcomes were 30-, 60- and 90-day survival, BSI, time used and saved personnel costs.
   Results: A total of 113 patients underwent 960 surgical procedures including 443 VAC changes as a single procedure, of which 165 (37 %) were performed in the ICU. Nine patients died before the first scheduled dressing change and six patients were closed at the first scheduled surgery after established OA, leaving 98 patients for further analysis. The mean duration for the surgical team performing a VAC change in the ICU was 63.4 (60.4-66.4) minutes and in the OR 98.2 (94.6-101.8) minutes (p < 0.001). The mean duration for the anesthesia team in the OR was 115.5 minutes, while this team was not used in the ICU. Personnel costs were reduced by (sic)682 per procedure when using the ICU. Forty-two patients had all the VAC changes done in the OR (VAC-OR), 22 in the ICU (VAC-ICU) and 34 in both OR and ICU (VAC-OR/ICU). BSI was diagnosed in eight (19 %) of the VAC-OR patients, seven (32 %) of the VAC-ICU and eight (24 %) of the VAC-OR/ICU (p = 0.509). Thirty-five patients (83 %) survived 30 days in the VAC-OR group, 17 in the VAC-ICU group (77 %) and 28 (82 %) in the VAC-OR/ICU group (p = 0.844).
   Conclusions: VAC change for OA in the ICU saved time for the OR team and the anesthesia team compared to using the OR, and it reduced personnel costs. Importantly, the use of ICU for OA dressing change seemed to be as safe as using the OR.
C1 [Seternes, Arne; Dahl, Torbjorn] Univ Trondheim Hosp, St Olavs Hosp, Dept Vasc Surg, Prinsesse Kristinas Gate 3, N-7030 Trondheim, Norway.
   [Seternes, Arne; Fasting, Sigurd; Klepstad, Pal; Dahl, Torbjorn] Norwegian Univ Sci & Technol NTNU, Dept Circulat & Med Imaging, Hogskoleringen 1, N-7491 Trondheim, Norway.
   [Fasting, Sigurd; Klepstad, Pal; Mo, Skule] Univ Trondheim Hosp, St Olavs Hosp, Dept Anesthesiol & Intens Care Med, Prinsesse Kristinas Gate 3, N-7030 Trondheim, Norway.
   [Wibe, Arne] Univ Trondheim Hosp, St Olavs Hosp, Dept Gastrointestinal Surg, Prinsesse Kristinas Gate 3, N-7030 Trondheim, Norway.
   [Bjorck, Martin] Uppsala Univ, Vasc Surg Sect, Dept Surg Sci, S-75185 Uppsala, Sweden.
   [Seternes, Arne; Wibe, Arne] Norwegian Univ Sci & Technol NTNU, Dept Canc Res & Mol Med, Hogskoleringen 1, N-7491 Trondheim, Norway.
C3 Norwegian University of Science & Technology (NTNU); Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU); Norwegian University of Science &
   Technology (NTNU); Uppsala University; Norwegian University of Science &
   Technology (NTNU)
RP Seternes, A (通讯作者)，Univ Trondheim Hosp, St Olavs Hosp, Dept Vasc Surg, Prinsesse Kristinas Gate 3, N-7030 Trondheim, Norway.; Seternes, A (通讯作者)，Norwegian Univ Sci & Technol NTNU, Dept Circulat & Med Imaging, Hogskoleringen 1, N-7491 Trondheim, Norway.; Seternes, A (通讯作者)，Norwegian Univ Sci & Technol NTNU, Dept Canc Res & Mol Med, Hogskoleringen 1, N-7491 Trondheim, Norway.
EM arne.seternes@stolav.no
FU St. Olavs Hospital, Trondheim University Hospital
FX Thanks to Toril Rendum for helping to calculate the personnel costs. The
   main investigator received unrestricted grants from St. Olavs Hospital,
   Trondheim University Hospital. Written informed consent was obtained
   from the patients and participants for publication of their individual
   details and any accompanying images. The consent forms are held by the
   authors and are available for review by the Editor-in-Chief.
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NR 34
TC 12
Z9 13
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1466-609X
EI 1364-8535
J9 CRIT CARE
JI Crit. Care
PD MAY 28
PY 2016
VL 20
AR 164
DI 10.1186/s13054-016-1337-y
PG 8
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DN1UM
UT WOS:000376850900001
PM 27233244
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ng, JWG
   Cairns, SA
   O'Boyle, CP
AF Ng, J. W. G.
   Cairns, S. A.
   O'Boyle, C. P.
TI Management of the lower gastrointestinal system in burn: A comprehensive
   review
SO BURNS
LA English
DT Review
DE Gastrointestinal effects; Burns; Pseudo-obstruction; Bacterial
   translocation; Abdominal compartment syndrome; Perineal burn
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; PERITONEAL
   RESUSCITATION INDICATIONS; ACUTE COLONIC PSEUDOOBSTRUCTION; PEDIATRIC
   PERIANAL BURNS; IMPROVING GRAFT-SURVIVAL; CONTROL OPEN CELIOTOMIES;
   DAMAGE CONTROL SURGERY; LINEA ALBA FASCIOTOMY; THICKNESS SKIN-GRAFTS
AB Background: Burn produces complex gastrointestinal (GI) responses. Treatment, including large volume fluid resuscitation and opioid analgesia, may exacerbate GI dysfunction. Complications include constipation and opioid-induced bowel dysfunction (OBD), acute colonic pseudo-obstruction (ACPO), bacterial translocation and sepsis, and abdominal compartment syndrome (ACS). Contamination of perineal burns contributes to delayed healing, skin graft failure and sepsis and may impact upon morbidity and mortality. The authors carried out a literature review on management of the lower GI system in burn. This study aimed to explain: current prevention and treatment modalities; drawbacks and complications associated with available treatments, and to provide direction for development of best practice guidelines. ACS is associated with high mortality and should be treated with careful fluid resuscitation and diuresis, to minimise and remove oedema.
   Methods: A comprehensive search of English language literature was performed on PubMed, Medline and Embase. Both MeSH and keywords searches were used.
   Results: Evidence available on the management of lower gastrointestinal system in burn is summarised. Levels of evidence available are generally low (level III-IV).
   Conclusion: Structured, graded interventions are required for prevention and treatment of constipation and OBD. Correction of electrolyte imbalance, adequate enteral intake and mobilisation are pre-requisites. Laxatives should be used according to World Gastroenterology Organisation recommendations. Resistant constipation may respond to changes in medication, but ACPO should be suspected and treated when present. Other complications, such as bacterial translocation and ACS are common in major burns. There is evidence that selective digestive tract decontamination reduces mortality and infectious episodes in major burns. ACS is associated with high mortality and should be treated with careful fluid resuscitation and diuresis. Surgery is reserved for non-responsive and severe cases. Perineal burns present challenges in wound and bowel management. Faecal management systems and negative pressure wound therapy (NPWT) may improve wound control and hygiene, but diversion colostomy will still be beneficial in some cases. There is a clear need for rigorous studies to guide practice more effectively in these challenging conditions. (C) 2015 Elsevier Ltd and ISBI. All rights reserved.
C1 [Ng, J. W. G.; Cairns, S. A.; O'Boyle, C. P.] Nottingham Univ Hosp NHS Trust, Dept Plast Reconstruct & Burns Surg, City Campus, Nottingham NG5 1PB, England.
C3 Nottingham University Hospital NHS Trust; Nottingham City Hospital
RP Ng, JWG (通讯作者)，Nottingham Univ Hosp NHS Trust, Dept Plast Reconstruct & Burns Surg, City Hosp Campus,Hucknall Rd, Nottingham NG5 1PB, England.
EM jimmyng@nhs.net
RI ; /J-5853-2019
OI Ng, Jimmy/0000-0003-1827-9647; 
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NR 72
TC 14
Z9 18
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD JUN
PY 2016
VL 42
IS 4
BP 728
EP 737
DI 10.1016/j.burns.2015.08.007
PG 10
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA DN2IC
UT WOS:000376886300012
PM 26774605
DA 2026-07-24
ER
PT J
AU Suh, H
   Lee, AY
   Park, EJ
   Hong, JP
AF Suh, Hyunsuk
   Lee, A-Young
   Park, Eun Jung
   Hong, Joon Pio
TI Negative Pressure Wound Therapy on Closed Surgical Wounds With Dead
   Space: Animal Study Using a Swine Model
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; surgical wound dehiscence; primary
   closure; subcutaneous dead space
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; MEDIASTINITIS; MANAGEMENT;
   INFECTIONS; INCISIONS; SURGERY
AB Background Closed incisional wound surgery frequently leaves dead space under the repaired skin, which results in delayed healing. The purpose of this study was to evaluate the effect of negative pressure wound therapy (NPWT) on incisional wounds with dead space after primary closure by evaluating the fluid volume through the suction drain, blood flow of the skin, tensile strength, and histology of the wounds.
   Methods Bilateral 25-cm-long incisional wounds with dead space were created on the back of 6 pigs by partially removing the back muscle and then suturing the skin with nylon sutures. NPWT (experimental group) or gauze dressing (control group) was applied over the closed incision for 7 days. Analysis of the wound included monitoring the amount of closed suction drain, blood perfusion unit, tensile strength of the repaired skin, and histology of the incision site.
   Results The drainage amount was significantly reduced in the experimental group (49.8 mL) compared to the control group (86.2 mL) (P = 0.046). Skin perfusion was increased in the experimental group with statistical significance compared to the control group (P = 0.0175). Collagen staining was increased in the experimental group. The tensile strength of the incision site was significantly higher in the experimental group (24.6 N at 7 days, 61.67 N at 21 days) compared to the control group (18.26 N at 7 days, 50.05 N at 21 days) (P = 0.02).
   Conclusion This study explains some of the mechanism for using NPWT in closed incision wounds with dead space. It demonstrates that NPWT significantly reduces drainage amount, increases skin perfusion, increases tensile strength, and has the tendency to promote collagen synthesis for closed wound with dead space indicating enhanced healing.
C1 [Suh, Hyunsuk] Ewha Womans Univ Hosp, Dept Plast Surg, Seoul, South Korea.
   [Lee, A-Young; Park, Eun Jung; Hong, Joon Pio] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Plast Surg, Seoul, South Korea.
C3 Ewha Womans University; University of Ulsan; Asan Medical Center
RP Hong, JP (通讯作者)，Asan Med Ctr, Dept Plast Surg, Poongnap2 Dong,388-1, Seoul 138736, South Korea.
EM joonphong@amc.seoul.kr
RI Hong, Joon/AEV-0712-2022; SUH, Hyunsuk/ABE-9911-2020
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NR 39
TC 66
Z9 77
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2016
VL 76
IS 6
BP 717
EP 722
DI 10.1097/SAP.0000000000000231
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DN3DU
UT WOS:000376943400022
PM 25003432
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Swanson, EW
   Cheng, HT
   Susarla, SM
   Lough, DM
   Kumar, AR
AF Swanson, Edward W.
   Cheng, Hsu-Tang
   Susarla, Srinivas M.
   Lough, Denver M.
   Kumar, Anand R.
TI Does negative pressure wound therapy applied to closed incisions
   following ventral hernia repair prevent wound complications and hernia
   recurrence? A systematic review and meta-analysis
SO PLASTIC SURGERY
LA English
DT Review
DE Abdominal wall reconstruction; Closed incision; Hernia recurrence;
   Negative pressure wound therapy; Seroma; Surgical site infection;
   Vacuum-assisted closure; Ventral hernia repair; Wound complications;
   Wound dehiscence
ID ABDOMINAL-WALL RECONSTRUCTION; SURGICAL-SITE INFECTION; VACUUM-ASSISTED
   CLOSURE; COMPONENT SEPARATION; SYNTHETIC MESH; RISK; OUTCOMES; COST
AB BACKGROUND: Despite advances in surgical technique, ventral hernia repair (VHR) remains associated with significant postoperative wound complications.
   OBJECTIVE: A systematic review and meta-analysis was performed to identify whether the application of negative pressure wound therapy to closed incisions (iNPWT) following VHR reduces the risk of postoperative wound complications and hernia recurrence.
   METHODS: The PubMed/MEDLINE, EMBASE and SCOPUS databases were searched for studies published through October 2015. Publications that met the following criteria were included: adult patients undergoing VHR; comparison of iNPWT with conventional dressings; and documentation of wound complications and/or hernia recurrence. The methodological quality of included studies was independently assessed using the Methodological Index for Non-Randomized Studies guidelines. Outcomes assessed included surgical site infection (SSI), wound dehiscence, seroma, and hernia recurrence. Meta-analysis was performed to obtain pooled ORs.
   RESULTS: Five retrospective cohort studies including 477 patients undergoing VHR were included in the final analysis. The use of iNPWT decreased SSI (OR 0.33 [95% CI 0.20 to 0.55]; P<0.0001), wound dehiscence (OR 0.21 [95% CI 0.08 to 0.55]; P=0.001) and ventral hernia recurrence (OR 0.24 [95% CI 0.08 to 0.75]; P=0.01). There was no statistically significant difference in the incidence of seroma formation (OR 0.59 [95% CI 0.27 to 1.27]; P=0.18).
   CONCLUSION: For patients undergoing VHR, current evidence suggests a decreased incidence in wound complications using incisional NPWT compared with conventional dressings.
C1 [Swanson, Edward W.; Cheng, Hsu-Tang; Susarla, Srinivas M.; Lough, Denver M.; Kumar, Anand R.] Johns Hopkins Univ, Sch Med, Dept Plast & Reconstruct Surg, Baltimore, MD USA.
   [Cheng, Hsu-Tang] China Med Univ, Sch Med, China Med Univ Hosp, Div Plast & Reconstruct Surg,Dept Surg, Taichung, Taiwan.
C3 Johns Hopkins University; China Medical University Taiwan; China Medical
   University Hospital - Taiwan
RP Kumar, AR (通讯作者)，Johns Hopkins Childrens Ctr, 1800 Orleans St,Bloomberg 7314A, Baltimore, MD 21281 USA.
EM akumar40@jhu.edu
RI ; Susarla, Srinivas/P-1051-2019
OI Swanson, Edward/0000-0001-5689-4419; Susarla,
   Srinivas/0000-0003-0155-8260; Kumar, Anand/0000-0002-4429-0236
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Basta MN, 2014, AM J SURG
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NR 26
TC 37
Z9 42
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2292-5503
EI 2292-5511
J9 PLAST SURG-CHIR PLAS
JI Plast. Surg.
PD SUM
PY 2016
VL 24
IS 2
BP 113
EP 118
DI 10.1177/229255031602400207
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DN6PR
UT WOS:000377198300010
PM 27441196
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Chen, RF
   Huang, LS
   Zheng, JB
   Jia, YQ
   Liu, YJ
   Shan, Y
AF Chen Rui-feng
   Huang Li-song
   Zheng Ji-bo
   Jia Yi-qing
   Liu Yu-jie
   Shan Yi
TI Negative pressure wound therapy for serious dog bites of extremities: a
   prospective randomized trial
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
ID MANAGEMENT; LACERATIONS; CLOSURE
AB Objectives: The objectives were to investigate the emergency treatment of serious dog bite lacerations on limbs and to identify whether negative pressure wound therapy (NPWT) was beneficial in these instances.
   Methods: A total of 580 cases with serious limb lacerations due to dog bites were randomly divided into 2 groups. After thorough debridement, the limblacerations of group A (n=329) were left open. The remaining cases (n=251) were randomly divided into 2 subgroups, group B and group C, which were treated with 125 and 75 mm Hg of continuous negative pressure, respectively. Antibiotics were only used in cases where there were systemic signs of wound infection, and were not given prophylactically. The infection rate, infection time, and healing time were analyzed.
   Results: The wound infection rates of groups A, B, and C were 9.1%, 4.1%, and 3.9%, respectively. The infection times of the 3 groups were 26.3 +/- 11.6, 159.8 +/- 13.4, and 166.4 +/- 16.2 hours, respectively. The recovery times of the infection patients in the 3 groups were 19.2 +/- 4.6, 13.2 +/- 2.1, and 12.7 +/- 2.3 days, respectively, and in the noninfection patients, the recovery times were 15.6 +/- 2.7, 10.1 +/- 2.3, and 10.5 +/- 1.9 days, respectively. In groups B (-125 mm Hg) and C (-75 mm Hg), the infection rate, infection time, and healing time showed no significant differences.
   Conclusion: Patients with serious dog bite laceration on limbs could benefit from NPWT. Compared with the traditional treatment of leaving the wounds open, NPWT reduced the infection rate and shortened recovery time. When NPWT was performed, low negative pressure (-75 mm Hg) had the same positive effects as high pressure (-125 mm Hg). Prophylactic antibiotics administration is not recommended for treating this kind of laceration.
   Level of evidence: Therapeutic/care management, level II. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Chen Rui-feng; Huang Li-song; Zheng Ji-bo; Jia Yi-qing; Liu Yu-jie; Shan Yi] China Liberat Army, Dept Emergency, Naval Gen Hosp, Beijing 100048, Peoples R China.
RP Shan, Y (通讯作者)，China Liberat Army, Dept Emergency, Naval Gen Hosp, Beijing 100048, Peoples R China.
EM cc_rrff@126.com; navyhuang76@163.com; hjzyyjzk@126.com;
   yiqing_1983@126.com; ff2061222@163.com; shanyi_navy@126.com
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NR 37
TC 11
Z9 11
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
EI 1532-8171
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD JUN
PY 2016
VL 34
IS 6
BP 1006
EP 1010
DI 10.1016/j.ajem.2016.02.043
PG 5
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA DN8OO
UT WOS:000377338700013
PM 26964825
DA 2026-07-24
ER
PT J
AU Suzuki, H
   Watanabe, T
   Okazaki, T
   Notsuda, H
   Niikawa, H
   Matsuda, Y
   Noda, M
   Sakurada, A
   Hoshikawa, Y
   Aizawa, T
   Miura, T
   Okada, Y
AF Suzuki, H.
   Watanabe, T.
   Okazaki, T.
   Notsuda, H.
   Niikawa, H.
   Matsuda, Y.
   Noda, M.
   Sakurada, A.
   Hoshikawa, Y.
   Aizawa, T.
   Miura, T.
   Okada, Y.
TI Prolonged Negative Pressure Wound Therapy Followed by Split-Thickness
   Skin Graft Placement for Wide Dehiscence of Clamshell Incision After
   Bilateral Lung Transplantation: A Case Report
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article; Proceedings Paper
CT 14th Congress of the Asian-Society-of-Transplantation
CY AUG 23-26, 2015
CL Singapore, SINGAPORE
SP Asian Soc Transplantat
ID DELAYED CHEST CLOSURE; OUTCOMES
AB Clamshell incision is a standard approach for bilateral lung transplantation, providing a good operative field; however, once wide dehiscence occurs, its management is sometimes difficult because of intense immunosuppression and malnutrition of the recipient. A 22 year-old man with idiopathic pulmonary arterial hypertension underwent cadaveric bilateral lung transplantation through a clamshell incision using standard cardiopulmonary bypass. He developed wound dehiscence on postoperative day (POD) 20 that resulted in exposure of the bilateral fifth ribs and open pneumothorax. Considering the extreme malnutrition and emaciation of the recipient, we avoided initial closure of the dehiscence. After the debridement of necrotic tissue, negative pressure wound therapy was initiated on POD 25 and was continued for approximately 6 months with trafermin spray application. Eventually, the wound, including the fifth ribs, was completely covered with granulation tissue except for the wire tying the sternum. On POD 217, the patient underwent removal of the sternal wire followed by split-thickness skin grafting. His wound was successfully closed and he was discharged without activity limitation on POD 265.
C1 [Suzuki, H.; Watanabe, T.; Okazaki, T.; Notsuda, H.; Niikawa, H.; Matsuda, Y.; Noda, M.; Sakurada, A.; Hoshikawa, Y.; Okada, Y.] Tohoku Univ, Inst Dev Aging & Canc, Dept Thorac Surg, Sendai, Miyagi 9808575, Japan.
   [Aizawa, T.; Miura, T.] Tohoku Univ, Grad Sch Med, Dept Plast & Reconstruct Surg, Sendai, Miyagi 9808575, Japan.
C3 Tohoku University; Tohoku University
RP Watanabe, T (通讯作者)，Tohoku Univ, Dept Thorac Surg, Inst Dev Aging & Canc, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
EM tatsuaki_watanabe@yahoo.co.jp
RI Matsuda, Yasushi/AAB-4258-2021; 渡邉, 龍秋/PMQ-5150-2026
OI noda, masafumi/0000-0002-0318-3733
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   Force SD, 2006, ANN THORAC SURG, V81, P2020, DOI 10.1016/j.athoracsur.2006.01.050
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NR 9
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD APR
PY 2016
VL 48
IS 3
BP 982
EP 984
DI 10.1016/j.transproceed.2015.12.107
PG 3
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Immunology; Surgery; Transplantation
GA DN9TA
UT WOS:000377422400072
PM 27234784
DA 2026-07-24
ER
PT J
AU Dadaci, M
   Isci, ET
   Ince, B
   Altuntas, Z
   Evrenos, MK
   Uzun, H
   Sönmez, E
   Bitik, O
AF Dadaci, M.
   Isci, E. T.
   Ince, B.
   Altuntas, Z.
   Evrenos, M. K.
   Uzun, H.
   Sonmez, E.
   Bitik, O.
TI Negative pressure wound therapy in the early period after hand and
   forearm replantation: is it safe?
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hand replantation; forearm replantation; topical negative pressure
   treatment; vacuum assisted closure therapy; negative pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; BLOOD-FLOW; COMPLEX WOUNDS; SKIN-GRAFT;
   EXTREMITIES; SURGERY; WALL
AB Objective: In this study, effectiveness and reliability of negative pressure wound therapy (NPWT) in the early period after replantation will be examined retrospectively in a series of patients.
   Method: Patients who underwent replantation between 2007 and 2014, and had tissue defect or partial necrosis in the absence of a major circulation problem were included in this retrospective study. Following debridement of necrotic tissues on the postoperative 7-10 days, NPWT was applied to all patients one day later and adjusted as intermittent 75 mmHg pressure. Intermittent phase adjustment was arranged as 5 minutes suction and 2 minutes resting, and resting pressure was adjusted as 35 mmHg. NPWT was applied for six days and dressings were changed in every three days in the first six day period. Open wounds was debrided again and grafted with split-thickness skin graft and NPWT was continued over the graft for 4 days more.
   Results: There were 11 patients included of which nine amputations were complete and two were nearly total amputations of forearm. Granulation tissue was observed following 6 days of NPWT application in all patients. Graft survival was observed to be almost complete. Wound infection did not occur and tissue cultures obtained in the course of debridement were all negative. Partial oxygen saturations were between 96-99% during the NPWT.
   Conclusion: NPWT (75 mmHg) can be used in the intermittent mode in order to improve wound healing and shorten the period to start physical therapy in the early period after replantation and revascularisation.
C1 [Dadaci, M.; Ince, B.; Altuntas, Z.] Necmettin Erbakan Univ, Meram Fac Med, Dept Plast Reconstruct & Aesthet Surg, Konya, Turkey.
   [Isci, E. T.] Acibadem Healty Grp Private Aile Hosp, Clin Plast Reconstruct & Aesthet Surg, Istanbul, Turkey.
   [Evrenos, M. K.] Celal Bayar Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Manisa, Turkey.
   [Uzun, H.; Bitik, O.] Hacettepe Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, TR-06100 Ankara, Turkey.
   [Sonmez, E.] Katip Celebi Univ, Ataturk State Hosp, Dept Plast Reconstruct & Aesthet Surg, Izmir, Turkey.
C3 Necmettin Erbakan University; Acibadem Hospitals Group; Celal Bayar
   University; Hacettepe University; Izmir Ataturk Training & Research
   Hospital; Izmir Katip Celebi University; Ataturk State Hospital
RP Dadaci, M (通讯作者)，Necmettin Erbakan Univ, Meram Fac Med, Dept Plast Reconstruct & Aesthet Surg, Konya, Turkey.
EM mdadaci@gmail.com
RI uzun, hakan/D-4811-2019; Uzun, Hafize/D-4811-2019; isci, evren
   tevfik/GYA-5663-2022; dadaci, mehmet/AAQ-5043-2021; bitik,
   ozan/KXR-9707-2024; ince, bilsev/AAF-8018-2020
OI uzun, hakan/0000-0002-7584-3833; Uzun, Hafize/0000-0002-1347-8498; 
CR Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Dadaci M, 2014, MICROSURG, V34, P503, DOI 10.1002/micr.22282
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   Mouës CM, 2011, AM J SURG, V201, P544, DOI 10.1016/j.amjsurg.2010.04.029
   Negosanti L, 2012, DERMATOL THER, V25, P277, DOI 10.1111/j.1529-8019.2012.01451.x
   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
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   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
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   VEGFORS M, 1990, J CLIN MONITOR, V6, P1, DOI 10.1007/BF02832175
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   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
   Wood Benjamin C, 2011, J Surg Orthop Adv, V20, P168
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NR 23
TC 7
Z9 9
U1 0
U2 18
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2016
VL 25
IS 6
BP 350
EP 355
DI 10.12968/jowc.2016.25.6.350
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DO2KY
UT WOS:000377610000007
PM 27286668
DA 2026-07-24
ER
PT J
AU Liu, X
   Liang, JL
   Zhao, J
   Quan, LL
   Jia, XY
   Li, MC
   Tao, K
AF Liu, Xin
   Liang, Jiulong
   Zhao, Jun
   Quan, Liangliang
   Jia, Xunyuan
   Li, Mingchao
   Tao, Kai
TI Vacuum Sealing Drainage Treatment Combined with Antibiotic-Impregnated
   Bone Cement for Treatment of Soft Tissue Defects and Infection
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Antibiotics, Antineoplastic; Soft Tissue Infections; Vacuum
ID TOTAL KNEE ARTHROPLASTY; TOPICAL ANTIBIOTICS; EMERGING STANDARD;
   PROPHYLACTIC USE; REPLACEMENT; THERAPY; CLOSURE; INJURY
AB Background: This study aimed to evaluate the combined effect of vacuum sealing drainage (VSD) and antibiotic-loaded bone cement on soft tissue defects and infection.
   Material/Methods: This prospective non-blinded study recruited 46 patients with soft tissue defects and infection from January 2010 to May 2014 and randomly divided them into experimental and control groups (n=23). Patients in the experimental group were treated with VSD and antibiotic-loaded bone cement, while the patients in the control group were treated with VSD only.
   Results: In the experimental group, the wound was healed in 23 cases at 4 weeks postoperatively, of which direct suture was performed in 12 cases, and additional free flap transplantation or skin grafting was performed in 6 cases and 5 cases, respectively. No infection reoccurred in 1-year follow-up. In the control group, the wound was healed in 15 cases at 6 weeks postoperatively, of which direct suture was performed in 8 cases, and additional free flap transplantation or skin grafting was performed in 3 cases and 4 cases, respectively. In the other 8 cases the wound was healed at 8 weeks postoperatively. Infection reoccurred in 3 cases during the follow-up. The experimental group had significantly fewer VSD dressing renewals, shorter time needed until the wound was ready for surgery, shorter duration of antibiotic administration, faster wound healing, and shorter hospital stay than the control group (p<0.01).
   Conclusions: The combination of VSD and antibiotic bone cement might be a better method for treatment of soft tissue defects and infection.
C1 [Liu, Xin; Zhao, Jun; Jia, Xunyuan; Li, Mingchao] First Hosp Harbin City, Dept Orthoped Ward 7, Harbin, Heilongjiang, Peoples R China.
   [Liang, Jiulong; Quan, Liangliang; Tao, Kai] Shenyang Mil Area Command PLA, Gen Hosp, Dept Plast Surg, Shenyang, Liaoning, Peoples R China.
RP Liu, X (通讯作者)，First Hosp Harbin City, Dept Orthoped Ward 7, Harbin, Heilongjiang, Peoples R China.; Tao, K (通讯作者)，Shenyang Mil Area Command PLA, Gen Hosp, Dept Plast Surg, Shenyang, Liaoning, Peoples R China.
EM xinliuliud@163.com; kaitaokaitt@163.com
RI ; Li, Mingchao/GZG-5876-2022
OI Liang, Jiulong/0000-0001-6335-4795; 
FU Harbin Innovative Talent in Science and Technology special funds
   [2012RFQYS068]
FX This study was supported by Harbin Innovative Talent in Science and
   Technology special funds (Grant No. 2012RFQYS068)
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NR 32
TC 25
Z9 37
U1 0
U2 21
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JUN 9
PY 2016
VL 22
BP 1959
EP 1965
DI 10.12659/MSM.896108
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DO2RT
UT WOS:000377628300001
PM 27281233
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Salvo, P
   Smajda, R
   Dini, V
   Saxby, C
   Voirin, G
   Romanelli, M
   Di Francesco, F
AF Salvo, P.
   Smajda, R.
   Dini, V.
   Saxby, C.
   Voirin, G.
   Romanelli, M.
   Di Francesco, F.
TI A D-optimal design to model the performances of dressings and devices
   for negative pressure wound therapy
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Wound dressing; Exudate transit time; D-optimal design; Negative
   pressure wound therapy; Chronic wounds
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; ULCERS
AB A D-optimal design was used to identify and model variables that affect the transit time of wound exudate through an illustrative dressing used for negative pressure wound therapy. Many authors have addressed the clinical benefits of negative pressure wound therapy, but limited information is available on how to assess performances of dressings. In this paper, the transit time of wound exudate through a dressing was chosen as a model parameter to show how experimental design (DOE) can be used for this purpose. Results demonstrated that rate of exudate production, temperature and dressing thickness were the variables with the largest impact on transit time. The DOE approach could be used to model other dressing properties, like for example capability of absorbing excess exudate or breath ability. (C) 2016 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.
C1 [Salvo, P.; Di Francesco, F.] Univ Pisa, Dept Chem & Ind Chem, Via Moruzzi 13, I-56124 Pisa, Italy.
   [Smajda, R.; Voirin, G.] CSEM SA, Rue Jaquet Droz 1, CH-2002 Neuchatel, Switzerland.
   [Dini, V.; Romanelli, M.] Univ Pisa, Dept Dermatol, Wound Healing Res Unit, Via Roma 67, I-56126 Pisa, Italy.
   [Saxby, C.] Smith & Nephew, Hessle Rd 101, Kingston Upon Hull, N Humberside, England.
C3 University of Pisa; Swiss Center for Electronics & Microtechnology
   (CSEM); University of Pisa; Smith & Nephew
RP Di Francesco, F (通讯作者)，Univ Pisa, Dept Chem & Ind Chem, Via Moruzzi 13, I-56124 Pisa, Italy.
EM pietro.salvo@gmail.com; valentinadini74@gmail.com;
   m.romanelli@med.unipi.it; fabio.difrancesco@unipt.it
RI dini, valentina/F-7747-2017; /L-6895-2019; Di Francesco,
   Fabio/I-8756-2012; romanelli, marco/ABI-1154-2020; Salvo,
   Pietro/G-3161-2014
OI dini, valentina/0000-0002-8537-1999; Di Francesco,
   Fabio/0000-0002-9285-1595; romanelli, marco/0000-0002-4127-0141; 
FU EU [ICT-317894]
FX This work was supported by the EU-funded FP7 ICT-317894 SWAN-iCare
   project.
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NR 25
TC 7
Z9 9
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-206X
J9 J TISSUE VIABILITY
JI J. Viab.
PD MAY
PY 2016
VL 25
IS 2
BP 83
EP 90
DI 10.1016/j.jtv.2016.01.001
PG 8
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA DO5PZ
UT WOS:000377836600002
PM 26818777
DA 2026-07-24
ER
PT J
AU Ma, ZJ
   Jian, C
   Li, ZH
   Wang, WY
   Shou, KQ
   Qi, BW
   Yu, AX
AF Ma, Zhanjun
   Jian, Chao
   Li, Zonghuan
   Wang, Weiyang
   Shou, Kangquan
   Qi, Baiwen
   Yu, Aixi
TI Negative pressure wound therapy improves the quantity and quality of
   wound angiogenesis in diabetic rats by regulating the Ang/Tie-2 system
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Negative pressure wound therapy; pericyte; vessel maturation; vessel
   stabilization
ID VACUUM-ASSISTED CLOSURE; VESSEL MATURATION; GROWTH; EXPRESSION;
   PERICYTES; PROLIFERATION; VASCULARITY; TUMORS
AB Negative pressure wound therapy can accelerate wound healing by promoting angiogenesis. However, what and how the signal pathway regulated angiogenesis and vessels maturation, and how the microvesels changed at different stage after negative pressure wound therapy treatment during the wound healing remain unclear. This study aimed to investigate the underlying molecular mechanisms and signal pathways of negative pressure wound therapy on angiogenesis and vessel maturation. Deep partial-thickness wounds were created in diabetic rats, and relevant growth factors were determined. Negative pressure wound therapy increased the angiogenin-2 and a-smooth muscle protein expression levels, and decreased angiogenin-1/angiogenin-2 expression ratios and phosphorylation levels of tyrosine kinase receptor-2 at early stage (1st to 3rd day) of wound healing. At later stage (7th to 10th day) of wound healing, negative pressure wound therapy increased angiogenin-1, alpha-smooth muscle protein, angiogenin-1/angiogenin-2 ratios expression and phosphorylation levels of tyrosine kinase receptor-2, simultaneously increased microvessel pericyte coverage index. Negative pressure wound therapy may not only predominantly promote microvessels destabilization and thus increase the quantity of initial angiogenesis in the early stage but also preferentially promote microvessels stabilization and thus enhance the quality of formed vessels, contributing to vessels maturation. And a tyrosine kinase receptor-2 inhibitor could moderately influence angiogenesis process during the early stage but affect vascular remodeling and maturation process significantly during the later stage of wound healing. Furthermore, it demonstrated that angiogenin/tyrosine kinase receptor-2 signal pathway play a primary role in regulating the process of the vessel maturation.
C1 [Ma, Zhanjun; Jian, Chao; Li, Zonghuan; Wang, Weiyang; Shou, Kangquan; Qi, Baiwen; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, 169 Donghu Rd, Wuhan 430071, Peoples R China.
C3 Wuhan University
RP Qi, BW; Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, 169 Donghu Rd, Wuhan 430071, Peoples R China.
EM wb002162@whu.edu.cn; yuaixi@whu.edu.cn
RI /E-6566-2018
FU National Natural Science Foundation of China [81572163]; Hubei National
   Natural Science Fund projects [2014CFB751]
FX This study was supported by the National Natural Science Foundation of
   China (No. 81572163) and by Hubei National Natural Science Fund projects
   (No. 2014CFB751). The funders had no role in the study design, date
   collection and analysis, decision to publish or preparation of the
   manuscript. We would like to acknowledge the Wuhan VSD Medical Science &
   Technology, Co., Ltd. (Wuhan, China) for supplying the vacuum material.
   We also thank the Medical Science Experimentation Center of Wuhan
   University providing the experiment equipment.
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   Sharifian Z, 2014, LASER MED SCI, V29, P1227, DOI 10.1007/s10103-013-1500-5
   Stratman AN, 2012, MICROSC MICROANAL, V18, P68, DOI 10.1017/S1431927611012402
   Tsourdi E, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/385641
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   Weidner N, 1998, J PATHOL, V184, P119, DOI 10.1002/(SICI)1096-9896(199802)184:2<119::AID-PATH17>3.0.CO;2-D
   Xia CY, 2014, MOL MED REP, V9, P1749, DOI 10.3892/mmr.2014.1997
   Yonenaga Y, 2005, ONCOLOGY-BASEL, V69, P159, DOI 10.1159/000087840
   Zhao JL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092691
   Zhao W, 2007, CHINESE MED J-PEKING, V120, P274, DOI 10.1097/00029330-200702020-00003
NR 40
TC 1
Z9 1
U1 0
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2016
VL 9
IS 3
BP 5463
EP 5475
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DO7JY
UT WOS:000377959900019
DA 2026-07-24
ER
PT J
AU Zahoor, B
   Kent, S
   Wall, D
AF Zahoor, Bilal
   Kent, Stephen
   Wall, Daryl
TI Cutaneous mucormycosis secondary to penetrative trauma
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE Mucormycosis; Trauma; Management; Treatment; Diagnosis
ID INFECTIONS; MANAGEMENT; INJURIES; PATIENT
AB Introduction: Mucormycosis is a rare but serious sequelae of penetrating trauma [1-5]. In spite of aggressive management, mortality remains high due to dissemination of infection. We completed a review of literature to determine the most optimal treatment of cutaneous mucormycosis which occurs secondary to penetrating trauma.
   Methods: We completed a review regarding the management of mucormycosis in trauma patients. We selected a total of 36 reports, of which 18 were case-based, for review.
   Results: Surgical debridement is a primary predictor of improved outcomes in the treatment of mucormycosis [3,6,7]. Anti-fungal therapy, especially lipid soluble formulation of Amphotericin B, is helpful as an adjunct or when surgical debridement has been maximally achieved. Further research is needed to fully evaluate the impact of topical dressings; negative pressure wound therapy is helpful.
   Conclusion: An aggressive and early surgical approach, even at the expense of disfigurement, is necessary to reduce mortality in the setting of cutaneous mucormycosis that results from penetrating trauma [4,8,9]. Anti-fungal therapy and negative pressure wound therapy are formidable adjuncts. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Zahoor, Bilal; Wall, Daryl] Royal Brisbane & Womens Hosp, Dept Trauma, Brisbane, Qld Au 4005, Australia.
   [Kent, Stephen] Royal Brisbane & Womens Hosp, Dept Orthopaed, Brisbane, Qld Au 4005, Australia.
   [Zahoor, Bilal; Wall, Daryl] Univ Queensland, Sch Med, Brisbane, Qld Au 4005, Australia.
   [Zahoor, Bilal] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD 21231 USA.
C3 Royal Brisbane & Women's Hospital; Royal Brisbane & Women's Hospital;
   University of Queensland; Johns Hopkins University
RP Zahoor, B (通讯作者)，Royal Brisbane & Womens Hosp, Dept Trauma, Brisbane, Qld Au 4005, Australia.
EM bilal.zahoor@uqconnect.edu.au
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   Zygomycosis (mucormycosis), 2013, ZYGOMYCOSIS MUCORMYC
NR 36
TC 17
Z9 18
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JUL
PY 2016
VL 47
IS 7
BP 1383
EP 1387
DI 10.1016/j.injury.2016.03.011
PG 5
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA DO8QL
UT WOS:000378048300003
PM 27126769
DA 2026-07-24
ER
PT J
AU Andres, T
   von Lübken, F
   Friemert, B
   Achatz, G
AF Andres, Torsten
   von Luebken, Falk
   Friemert, Benedikt
   Achatz, Gerhard
TI Vacuum-Assisted Closure in the Management of Degloving Soft Tissue
   Injury: A Case Report
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE avulsion; degloving injury; foot; soft tissue defect; trauma;
   vacuum-assisted wound closure
ID FRACTURES
AB We report the case of a patient with an extensive degloving injury to his right foot involving severe subcutaneous soft tissue disruption and contamination. The initial treatment consisted of debridement, which was kept to a minimum, copious irrigation, primary wound closure at a few sites, and coverage of the remaining skin defects with vacuum-assisted closure (VAC) dressings. After a few weeks of VAC therapy for wound bed preparation, definitive coverage with a meshed skin graft was possible. Additional plastic surgical procedures were not required. At the last follow-up visit, the patient had no complaints and was able to participate in normal social life without limitations. Wounds that are grossly contaminated or associated with extensive soft tissue defects often require a multistage approach before delayed primary wound closure or plastic surgical procedures can be performed. Vacuum therapy can be used for temporary soft tissue coverage and has been shown to improve bacterial clearance, to increase local blood flow, and to promote granulation tissue formation. In contrast, plastic surgical procedures initially achieve safe and stable wound closure; however, the absence of sensitivity can lead to secondary problems. This is of particular relevance if the graft recipient site is subject to heavy stress and the restoration of function is of paramount importance, such as in the present case. Vacuum therapy is an effective and safe treatment of degloving injuries. We achieved a very good functional outcome, which was particularly important in view of the high stresses and strains to which a foot is exposed. (C) 2016 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Andres, Torsten; Friemert, Benedikt] German Armed Forces Hosp Ulm, Dept Orthopaed & Trauma Surg Reconstruct & Sept S, Oberer Eselsberg 40, D-89081 Ulm, Germany.
   [Andres, Torsten; Friemert, Benedikt; Achatz, Gerhard] German Soc Trauma Surg, Working Grp Ultrasound, Berlin, Germany.
   [von Luebken, Falk] German Armed Forces Hosp Ulm, Foot & Ankle Div, Dept Orthopaed & Trauma Surg Reconstruct & Sept S, D-89081 Ulm, Germany.
   [Achatz, Gerhard] German Armed Forces Hosp Ulm, Shoulder & Elbow Div, Dept Orthopaed & Trauma Surg Reconstruct & Sept S, D-89081 Ulm, Germany.
C3 Ulm University; Military Hospital Ulm; Ulm University; Military Hospital
   Ulm; Ulm University; Military Hospital Ulm
RP Andres, T (通讯作者)，German Armed Forces Hosp Ulm, Dept Orthopaed & Trauma Surg Reconstruct & Sept S, Oberer Eselsberg 40, D-89081 Ulm, Germany.
EM TorstenAndres@bundeswehr.org
RI /ABI-6295-2020
OI Anes, Torsten/0000-0002-2665-688X
CR Berger A, 2002, TSCHERNE UNFALLCHIRU, P183
   Damert HG, 2009, CHIRURG, V80, P448, DOI 10.1007/s00104-008-1586-7
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NR 17
TC 6
Z9 10
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JUL-AUG
PY 2016
VL 55
IS 4
BP 852
EP 856
DI 10.1053/j.jfas.2015.12.002
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA DO8YL
UT WOS:000378071300032
PM 26826925
DA 2026-07-24
ER
PT J
AU Horta, R
   Nascimento, R
   Silva, M
   Amarante, J
AF Horta, Ricardo
   Nascimento, Ricardo
   Silva, Mdalvaro
   Amarante, Jose
TI The Free-style Gluteal Perforator Flap in the Thinning and Delay Process
   for Perineal Reconstruction After Necrotizing Fasciitis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE free-style; perforator flap; perineal reconstruction; necrotizing
   fasciitis
ID VACUUM-ASSISTED CLOSURE; BREAST RECONSTRUCTION; NEGATIVE-PRESSURE;
   DEFECTS; ARTERY; COMPLICATIONS; ELEVATION
AB Perineal wounds present a special Challenge for reconstructive surgeons. The vacuum-assisted closure device is useful as a temporizing measure or for wounds too large or contaminated for immediate reconstruction. Compared to traditional myocutaneous flaps, perforator flaps provide thinner fasciocutaneous flaps for perineal reconstruction with favorable results and fewer donor site morbidities. The upper and lower gluteal regions are rich in perforators, which allow for more versatile flap design according to the defect. The authors combined the principles of free-Style perforator flaps, flap delay, and thinning of perforator flaps to restore perineal function and aesthetics. The procedure was undertaken in a 72-year-old female who was Obese with the diagnosis of necrotizing fasciitis Secondary to perineal abscess. After 3 months, the flap achieved adequate and durable reconstruction with acceptable aesthetic contour and patient satisfaction; there was no loss of function at donor sites. Clinical applications and technical refinements of freestyle pedicled perforator flaps can be extended to the perineal region. Because of its many advantages and its versatility, freestyle pedicled perforator flaps constitute a valued reconstructive option and, when indicated, an alternative to pedicled axial flaps or even free flaps, in addition to vacuum therapy, to simplify the reconstructive procedure.
C1 [Horta, Ricardo; Nascimento, Ricardo; Silva, Mdalvaro; Amarante, Jose] Ctr Hosp Sao Joao, Dept Plast Reconstruct & Maxillofacial Surg & Bur, Oporto, Portugal.
C3 Sao Joao Hospital
RP Horta, R (通讯作者)，Ctr Hosp Sao Joao, Dept Plast Reconstruct & Maxillofacial Surg & Bur, Fac Med, Oporto, Portugal.
EM ricardojmhorta@gmail.com
RI ; Amarante, José Manuel/O-9050-2014
OI Horta, Ricardo/0000-0002-4658-1889; Amarante, José
   Manuel/0000-0003-4917-6915
CR Acartürk TO, 2015, J HAND MICROSURG, V7, P1, DOI 10.1007/s12593-014-0124-8
   Assenza M, 2011, CLIN TER, V162, pE1
   Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
   Bravo FG, 2009, J PLAST RECONSTR AES, V62, P602, DOI 10.1016/j.bjps.2008.11.086
   Brunetti B, 2013, PLAST RECONSTR SURG, V132, P451, DOI 10.1097/PRS.0b013e3182958897
   Chaput B, 2015, ARCH PLAST SURG-APS, V42, P242, DOI 10.5999/aps.2015.42.2.242
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   Salgado Christopher J, 2011, Semin Plast Surg, V25, P155, DOI 10.1055/s-0031-1281485
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   Tu GW, 2013, INFECTION, V41, P583, DOI 10.1007/s15010-012-0346-2
NR 28
TC 6
Z9 6
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2016
VL 28
IS 6
BP 200
EP 205
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DP5WJ
UT WOS:000378568600007
PM 27434419
DA 2026-07-24
ER
PT J
AU Govea-Camacho, LH
   Astudillo-Carrera, A
   Hermosillo-Sandoval, JM
   Rodríguez-Reynoso, S
   González-Ojeda, A
   Fuentes-Orozco, C
AF Humberto Govea-Camacho, Luis
   Astudillo-Carrera, Andrea
   Manuel Hermosillo-Sandoval, Jose
   Rodriguez-Reynoso, Sergio
   Gonzalez-Ojeda, Alejandro
   Fuentes-Orozco, Clotilde
TI Impact of vacuum-assisted closure management in deep neck abscesses
SO CIRUGIA Y CIRUJANOS
LA Spanish
DT Article
DE Deep neck abscesses; Vacuum assisted closure therapy; Wound suture
ID THERAPY; INFECTIONS; MECHANISM; WOUNDS; HEAD
AB Background: The presence of deep neck abscesses is potentially serious; they can lead to death in a short period of time. The vacuum-assisted closure (V.A.C.) therapy has been used in many areas of surgery for complex wound healing. This treatment modality has recently been considered in the field of head and neck surgery.
   Objective: Evaluate the efficacy of healing therapy using V.A.C. therapy in deep neck abscesses.
   Material and methods: Open-label trial. Patients with deep neck abscesses were included using V.A.C. therapy versus conventional therapy. Cultures were taken before and during surgery, and prior to primary wound closure. The percentages of healing, viable tissue, wound healing time, and hospital stay were evaluated.
   Results: A total of 18 patients were included. Affected neck spaces: submaxilar 29%, parapharyngeal 22%, submental 21% and masticatory 13%. The final postsurgical culture was negative in 78%. Viable tissue of the wound for the V.A.C. group was 42%, and for the control group was 36% (p = 0.025). Healing time was 22 +/- 6 days and 38 +/- 15.5, respectively (p = 0.01). The mean number of hospital stay was 12 days for both groups.
   Conclusions: Therapy with V.A.C. is useful in the treatment of deep neck abscesses; it decreased healing time as a result of more viable tissue allowing suture closure of the wound in a shorter period. (C) 2015 Academia Mexicana de Cirugia A.C. Published by Masson Doyma Mexico S.A.
C1 [Humberto Govea-Camacho, Luis; Astudillo-Carrera, Andrea] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Occidente, Inst Mexicano Seguro Social, Dept Cirugia Cabeza & Cuello, Guadalajara, Jalisco, Mexico.
   [Manuel Hermosillo-Sandoval, Jose] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Occidente, Inst Mexicano Seguro Social, Dept Cirugia Gen, Guadalajara, Jalisco, Mexico.
   [Rodriguez-Reynoso, Sergio] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Occidente, Inst Mexicano Seguro Social, Unidad Invest Quirurg Expt, Guadalajara, Jalisco, Mexico.
   [Gonzalez-Ojeda, Alejandro; Fuentes-Orozco, Clotilde] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Occidente, Inst Mexicano Seguro Social, Unidad Med Alta Especialidad,Unidad Invest Med Ep, Guadalajara, Jalisco, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Mexicano del Seguro
   Social; Instituto Mexicano del Seguro Social; Instituto Mexicano del
   Seguro Social
RP Fuentes-Orozco, C (通讯作者)，Calle Nebulosa 2975,Interior 6 C Col, Guadalajara 44520, Jalisco, Mexico.
EM clotildefuen@hotmail.com
RI ; Govea-Camacho, Luis Humberto/AAD-8368-2020
OI GONZALEZ OJEDA, ALEJANDRO/0000-0003-2935-8703; FUENTES OROZCO,
   CLOTILDE/0000-0001-6230-8359; Govea-Camacho, Luis
   Humberto/0000-0002-1141-1898
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   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
   Tejeda-Real ME, 1999, REV ASOC MEX MED CRI, V13, P142
   Vieira F, 2008, OTOLARYNG CLIN N AM, V41, P459, DOI 10.1016/j.otc.2008.01.002
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   Yang SW, 2011, INFECT DRUG RESIST
NR 27
TC 13
Z9 14
U1 0
U2 4
PU MEXICAN ACAD SURGERY
PI MEXICO D G
PA CENTRO MED NAC SIGLO XXI, EDIFICIO BLOQUE B, SOTANO, AVE CUAUHTEMOC NO
   330, MEXICO D G, 06700, MEXICO
SN 0009-7411
J9 CIR CIR
JI Cir. Cir.
PD JUL-AUG
PY 2016
VL 84
IS 4
BP 275
EP 281
DI 10.1016/j.circir.2015.12.004
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DP9FJ
UT WOS:000378801800003
PM 26908418
OA gold
DA 2026-07-24
ER
PT J
AU Kugler, NW
   Carver, TW
   Paul, JS
AF Kugler, Nathan W.
   Carver, Thomas W.
   Paul, Jasmeet S.
TI Negative pressure therapy is effective in abdominal incision closure
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Negative pressure wound therapy; VAC; Vacuum-assisted closure; Surgical
   site infection; SSI; Contamination; Dirty; Infected; Enterocutaneous
   fistula; Laparotomy
ID SURGICAL SITE INFECTIONS; WOUND THERAPY; MANAGEMENT-SYSTEM; RISK;
   PREVENTION; EXPERIENCE; SURGERY; SCIP
AB Background: CDC wound classification demonstrates surgical site infection (SSI) occurs in 15%-30% of contaminated (class III) and > 30% of dirty-infected (class IV) wounds. Several techniques have been used to decrease SSI rates in midline laparotomy incisions; however, no technique has shown superiority. Evidence suggests incisional negative pressure wound therapy (INPWT) can decrease wound complications, but no literature exists regarding INPWT for high-risk laparotomy incisions. We sought to analyze the efficacy of INPWT in the management of high-risk midline laparotomy incisions.
   Methods: Retrospective review of adult patients who underwent laparotomy between January 2013 and June 2014 with midline closure using INPWT. Only class III or IV wounds were included. Laparotomy incisions were loosely closed. INPWT set at 125 mm Hg is placed over oil emulsion impregnated gauze. INPWT is removed after 5 d and the wound left open to air. Records were reviewed for immediate and/or delayed surgical site complications. Primary end point was 30-d incisional SSI. Secondary end points included other surgical site complications.
   Results: One class III and 12 class IV wounds were treated with INPWT for a median of 5 d. The class III wound developed a small skin dehiscence with no evidence of superficial or deep SSI. Among class IV wounds, the rate of superficial and deep incisional SSI was 25% and 0%, respectively. The overall surgical site complication rate was 41.7%.
   Conclusions: INPWT in closure of high-risk midline laparotomy incisions is a safe, effective method of wound closure with equivalent SSI rates to previously described methods. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Kugler, Nathan W.; Carver, Thomas W.; Paul, Jasmeet S.] Med Coll Wisconsin, Dept Surg, Div Trauma & Crit Care, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Kugler, NW (通讯作者)，Dept Surg, Div Trauma & Crit Care, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
EM nkugler@mcw.edu
OI Kugler, Nathan/0000-0003-2411-2704; Paul, Jasmeet/0000-0002-4030-6624
FU Department of Surgery; Division of Trauma and Critical care
FX The authors would like to thank the Department of Surgery and the
   Division of Trauma and Critical care for their support in this project.
CR Anderson DJ, 2011, INFECT DIS CLIN N AM, V25, P135, DOI 10.1016/j.idc.2010.11.004
   [Anonymous], INFECT CONTROL HOSP
   Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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   FARNELL MB, 1986, ARCH SURG-CHICAGO, V121, P641
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NR 17
TC 18
Z9 25
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD JUN 15
PY 2016
VL 203
IS 2
BP 491
EP 494
DI 10.1016/j.jss.2016.04.032
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DP9XR
UT WOS:000378851700032
PM 27363660
DA 2026-07-24
ER
PT J
AU Naghavi, AO
   Gonzalez, RJ
   Scott, JG
   Mullinax, JE
   Abuodeh, YA
   Kim, Y
   Binitie, O
   Ahmed, KA
   Bui, MM
   Saini, AS
   Zager, JS
   Biagioli, MC
   Letson, D
   Harrison, LB
   Fernandez, DC
AF Naghavi, Arash O.
   Gonzalez, Ricardo J.
   Scott, Jacob G.
   Mullinax, John E.
   Abuodeh, Yazan A.
   Kim, Youngchul
   Binitie, Odion
   Ahmed, Kamran A.
   Bui, Marilyn M.
   Saini, Amarjit S.
   Zager, Jonathan S.
   Biagioli, Matthew C.
   Letson, Douglas
   Harrison, Louis B.
   Fernandez, Daniel C.
TI Implications of staged reconstruction and adjuvant brachytherapy in the
   treatment of recurrent soft tissue sarcoma
SO BRACHYTHERAPY
LA English
DT Article
DE Brachytherapy; Recurrent; STS; Sarcoma; Staged reconstruction; Delayed
   reconstruction; Negative pressure wound therapy; Vacuum; Radiation;
   Adjuvant
ID VACUUM-ASSISTED CLOSURE; DOSE-RATE BRACHYTHERAPY; LIMB-SPARING SURGERY;
   RADIATION-THERAPY; POSTOPERATIVE IRRADIATION; RANDOMIZED-TRIAL; LOCAL
   RECURRENCE; WOUND CONTROL; RADIOTHERAPY; EXTREMITY
AB PURPOSE: Prior studies illustrated a reduction in wound complications with the use of staged reconstruction (SR) and negative pressure wound therapy when treating soft tissue sarcoma (STS) with surgical resection followed by high-dose-rate adjuvant brachytherapy. The purpose of this study is to compare the outcomes of SR and immediate reconstruction (IR) brachytherapy in recurrent STS.
   METHODS AND MATERIALS: A retrospective review of 40 patients with recurrent STS of the local extremity and trunk treated with resection followed by adjuvant brachytherapy alone. Margin status was defined as positive (SM(+)) if there was microscopic involvement (R1) or <= 1 mm margin and negative (SM(-)) if >1 mm margin was obtained. SR and IR were compared regarding toxicity, local control, and limb preservation.
   RESULTS: Median followup was 27 months. When comparing the SR (n = 22) and IR (n = 18) cohorts, there was a significantly lower final SM(+) rate in SR (32% vs. 83%, p < 0.01). A 2-year local control benefit seen with SR (80% vs. 34%; p = 0.012) and a final SM(-) (81% vs. 39%; p = 0.023). SR was associated with less toxicity on multivariate analysis, including a 90% decrease in persistent edema, an 80% decrease in wound dehiscence, and a 94% decrease in nonhealing wounds, when compared to IR. Ten of 31 (32%) extremity cases required eventual amputation from either chronic wound complications (n = 4) or local recurrence (n = 6). SR predicted for a benefit in 2-year limb preservation (88% vs. 50%; p = 0.008).
   CONCLUSION: In our series, the treatment with SR brachytherapy resulted in less morbidity and an improved final SM(-) rate. This technique translated to an improvement in both local control and limb preservation of recurrent STS. (C) 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
C1 [Naghavi, Arash O.; Scott, Jacob G.; Abuodeh, Yazan A.; Ahmed, Kamran A.; Saini, Amarjit S.; Biagioli, Matthew C.; Harrison, Louis B.; Fernandez, Daniel C.] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiat Oncol, Tampa, FL 33612 USA.
   [Gonzalez, Ricardo J.; Mullinax, John E.; Binitie, Odion; Letson, Douglas] H Lee Moffitt Canc Ctr & Res Inst, Sarcoma Dept, Tampa, FL 33612 USA.
   [Kim, Youngchul] H Lee Moffitt Canc Ctr & Res Inst, Dept Biostat & Bioinformat, Tampa, FL 33612 USA.
   [Bui, Marilyn M.] H Lee Moffitt Canc Ctr & Res Inst, Dept Anat Pathol, Tampa, FL 33612 USA.
   [Zager, Jonathan S.] H Lee Moffitt Canc Ctr & Res Inst, Dept Cutaneous Oncol, Tampa, FL 33612 USA.
C3 H Lee Moffitt Cancer Center & Research Institute; H Lee Moffitt Cancer
   Center & Research Institute; H Lee Moffitt Cancer Center & Research
   Institute; H Lee Moffitt Cancer Center & Research Institute; H Lee
   Moffitt Cancer Center & Research Institute
RP Fernandez, DC (通讯作者)，H Lee Moffitt Canc Ctr & Res Inst, Radiat Oncol, 12902 USF Magnolia Dr, Tampa, FL 33612 USA.
EM Daniel.fernandez@moffitt.org
RI Ahmed, Kamran/AHC-3488-2022; Mullinax, John/L-2509-2014; Scott,
   Jacob/H-9634-2019; Naghavi, Arash/AHB-4226-2022; Fernandez,
   Daniel/ABE-2657-2021; Abuodeh, Yazan/C-1361-2017
OI Ahmed, Kamran/0000-0003-3331-1529; Mullinax, John/0000-0002-9596-6785;
   Scott, Jacob/0000-0003-2971-7673; Naghavi, Arash/0000-0002-0884-1942;
   Abuodeh, Yazan/0000-0002-7395-5882
FU NCI NIH HHS [P30 CA076292] Funding Source: Medline
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NR 43
TC 16
Z9 17
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1538-4721
EI 1873-1449
J9 BRACHYTHERAPY
JI Brachytherapy
PD JUL-AUG
PY 2016
VL 15
IS 4
BP 495
EP 503
DI 10.1016/j.brachy.2016.03.013
PG 9
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA DQ1RV
UT WOS:000378979000014
PM 27180128
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ma, YQ
   Liang, XP
   Shi, B
   Zhang, C
AF Ma, Yongqi
   Liang, Xianping
   Shi, Bing
   Zhang, Chen
TI Treatment of seawater-immersed blast-injury wounds of pig skin soft
   tissues using vacuum assisted closure technology
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Vacuum assisted closure; seawater immersion; blast injury; tumor
   necrosis factor-alpha; type I collagen; type III collagen
ID EXTRACELLULAR-MATRIX; MODEL
AB The aim of this study was to dynamically observe and compare the effects of vacuum-assisted closure (VAC) technology on the healing of seawater-immersed blast-injury wounds (SIBIW) of pig skin soft tissues, and to summarize the mechanisms of VAC technology in promoting such SIBIW healing, with the goal of providing new experimental evidence for the rescue of such wounds. The bilateral scapular regions and hips of 5 small pigs underwent SIBIW with detonators. After the debridement, the pigs were randomly divided into control and experiment groups (VAC-120 mmHg group, VAC-180 mmHg group, VAC-240 mmHg group), with 5 wounds in each group. The control group's dressings were changed daily, and the experiment group's dressings were changed every other day. All wounds were treated for 9 days, and were observed until they had all healed (i.e., on the 58th day). We then compared and observed the macroscopic and microscopic changes in the wounds of each group. Compared with the control group, the experimental groups showed more active proliferation of peri-wound cells, and faster crawling of the epithelium. In the early stage, the expression of type I collagen was low, while that of type III collagen was higher, the bacterial index decreased rapidly, the bacterial transition was faster, and the wound healed faster. In treating SIBIW, VAC technology had obvious advantages over conventional therapy.
C1 [Ma, Yongqi; Liang, Xianping; Shi, Bing] PLA, Hosp 309, Dept Orthopaed, 17 Heishanhu Rd, Beijing 100091, Peoples R China.
   [Zhang, Chen] Dalian Univ, Affiliated Xinhua Hosp, Dept Orthopaed, Dalian, Peoples R China.
C3 Dalian University
RP Shi, B (通讯作者)，PLA, Hosp 309, Dept Orthopaed, 17 Heishanhu Rd, Beijing 100091, Peoples R China.
EM bingshidoc@163.com
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NR 25
TC 1
Z9 1
U1 0
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2016
VL 9
IS 6
BP 11476
EP 11484
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DQ4ES
UT WOS:000379157300081
DA 2026-07-24
ER
PT J
AU Mintziras, I
   Miligkos, M
   Bartsch, DK
AF Mintziras, Ioannis
   Miligkos, Michael
   Bartsch, Detlef Klaus
TI High risk of fistula formation in vacuum-assisted closure therapy in
   patients with open abdomen due to secondary peritonitis-a retrospective
   analysis
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Vacuum-assisted closure therapy; Peritonitis; Open abdomen;
   Enterocutaneous fistula
ID TEMPORARY ABDOMINAL CLOSURE; PRESSURE WOUND THERAPY; FASCIAL CLOSURE;
   NONTRAUMA PATIENTS; SEPTIC PATIENTS; MANAGEMENT
AB The aim of this study was to evaluate the efficacy of vacuum-assisted closure therapy in patients with open abdomen due to secondary peritonitis and to identify possible risk factors of fistula formation.
   The hospital OPS-database (time period 2005-2014) was searched to identify patients treated with an open abdomen due to secondary peritonitis, who underwent vacuum-assisted closure therapy. Medical records were retrospectively analyzed for patients' characteristics, cause of peritonitis, duration of vacuum therapy, number of relaparotomies, fascial closure rates, and risk factors of fistula formation.
   Forty-three patients (19 male, 24 female) with a median age of 65 years (range 24-90 years) were identified. The major cause of secondary peritonitis was anastomotic leakage after intestinal anastomosis or bowel perforation, the median APACHE II score was 11. Median duration of VAC treatment was 12 days (range 3-88 days). Twenty of 43 (47 %) patients died from septic complications. Delayed fascial closure was obtained by suturing in 20 of 43 patients (47 %). Overall 16 of 43 (37 %) patients developed enteroatmospheric fistulas. Re-explorations after starting VAC treatment and duration of VAC therapy were significantly associated with the occurrence of enteroatmospheric fistulas (p < 0.001). ROC curve analysis determined the optimal duration of VAC therapy to reduce the risk of fistula formation at 13 days.
   Long-term VAC treatment of patients with an open abdomen due to secondary peritonitis results in a relatively low fascial closure rate and a high risk of fistula formation.
C1 [Mintziras, Ioannis; Bartsch, Detlef Klaus] Univ Marburg, Dept Visceral Thorac & Vasc Surg, Baldingerstr, D-35043 Marburg, Germany.
   [Miligkos, Michael] Univ Thessaly, Sch Med, Lab Biomath, Larisa, Greece.
C3 Philipps University Marburg; University of Thessaly
RP Mintziras, I (通讯作者)，Univ Marburg, Dept Visceral Thorac & Vasc Surg, Baldingerstr, D-35043 Marburg, Germany.
EM ioannis.mintziras@uk-gm.de
OI Miligkos, Michael/0000-0001-8021-2780
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NR 22
TC 22
Z9 33
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD AUG
PY 2016
VL 401
IS 5
BP 619
EP 625
DI 10.1007/s00423-016-1443-y
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DR1XP
UT WOS:000379698500005
PM 27150438
DA 2026-07-24
ER
PT J
AU Davis, KE
   Moquin, KJ
   Lavery, LA
AF Davis, Kathryn E.
   Moquin, Kenneth J.
   Lavery, Lawrence A.
TI The fluid dynamics of simultaneous irrigation with negative pressure
   wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE NPWT; Simultaneous irrigation; Wound irrigation; Wound model
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT WOUNDS; BENZALKONIUM CHLORIDE;
   POVIDONE-IODINE; INSTILLATION; INFECTION; BACITRACIN; SYSTEM;
   MULTICENTER; INSTILL(R)
AB Saline irrigation has been shown to be both experimentally and clinically efficacious in decreasing bacterial contamination as well as decreasing infection rates. The dynamics of irrigation delivery fall into two primary categories: simultaneous and intermittent irrigation. An important component to irrigation therapy is distribution of irrigation solution to hard-to-reach areas of a wound bed, including undermining and fissure-like structures. Here we test the effectiveness of simultaneous irrigation to fill the irregular structures of a wound bed. In order to visualise the dynamic movement of irrigation solution, three-dimensional wound models were constructed using clear synthetic ballistic gel. Wounds with the aforementioned characteristics were carved into the ballistic gel with varying area, depth and volume. All three wounds were dressed as per manufacturer's instructions. Data demonstrate that simultaneous irrigation is effective in reaching all parts of a wound bed in wound models that have both undermining and tunnelling, and irrigation effectively saturates bridged wounds. Finally, this study shows that there is constant turnover of irrigation solution in the wound that is driven more by administration volume and less by flow rate. These data show that simultaneous irrigation is an effective technique for delivering irrigation solution to both simple and complex wounds.
C1 [Davis, Kathryn E.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr, Dept Plast Surg, 5323 Harry Hines Blvd,F4-310A, Dallas, TX 75390 USA.
   [Moquin, Kenneth J.] Henry Ford Hosp, Dept Plast Surg, Detroit, MI 48202 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; Henry Ford Health System; Henry Ford Hospital
RP Davis, KE (通讯作者)，Univ Texas Southwestern Med Ctr, Dept Plast Surg, 5323 Harry Hines Blvd,F4-310A, Dallas, TX 75390 USA.
EM Kathryn.davis@utsouthwestern.edu
OI Lavery, Lawrence/0000-0002-7920-9952
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NR 61
TC 10
Z9 12
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2016
VL 13
IS 4
BP 469
EP 474
DI 10.1111/iwj.12456
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DR5JP
UT WOS:000379939600006
PM 25968404
OA Green Submitted
DA 2026-07-24
ER
PT J
AU De Caridi, G
   Massara, M
   Greco, M
   Pipitò, N
   Spinelli, F
   Grande, R
   Butrico, L
   de Franciscis, S
   Serra, R
AF De Caridi, Giovanni
   Massara, Mafalda
   Greco, Michele
   Pipito, Narayana
   Spinelli, Francesco
   Grande, Raffaele
   Butrico, Lucia
   de Franciscis, Stefano
   Serra, Raffaele
TI VAC therapy to promote wound healing after surgical revascularisation
   for critical lower limb ischaemia
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Critical lower limb ischaemia; Vacuum-assisted closure therapy; Wound
   healing
ID DIABETIC FOOT ULCERS; ASSISTED CLOSURE; TRIAL; GEL
AB Vacuum-assisted closure (VAC) therapy is a new emerging non-invasive system in wound care, which speeds up wound healing by causing vacuum, improving tissue perfusion and suctioning the exudates, and facilitating the removal of bacteria from the wound. The application of sub-atmospheric pressure on the lesions seems to alter the cytoskeleton of the cells on the wound bed, triggering a cascade of intracellular signals that increase the rate of cell division and subsequent formation of granulation tissue. The aim of this study is to analyse the results of VAC therapy used as an adjuvant therapy for the treatment of foot wounds in patients affected by critical limb ischaemia (CLI) (Rutherford 6 class) after distal surgical revascularisation, to promote and accelerate the healing of ulcers. Twenty-nine patients (20 males, 9 females; mean age 68.4) affected by CLI of Rutherford 6 class, after surgical revascularisation of the lower limb, underwent VAC therapy in order to speed upwound healing. Completewound healingwas achieved in 19 patients (65.51%), in an average period of 45.4 +/- 25.6 days. VAC therapy is a valid aid, after surgical revascularisation, to achieve rapid healing of foot lesions in patients with CLI.
C1 [De Caridi, Giovanni; Massara, Mafalda; Greco, Michele; Pipito, Narayana; Spinelli, Francesco] Univ Messina, Cardiovasc & Thorac Dept, Policlin G Martino Hosp, Messina, Italy.
   [Grande, Raffaele; Butrico, Lucia; de Franciscis, Stefano; Serra, Raffaele] Magna Graecia Univ Catanzaro, Dept Surg & Med Sci, Catanzaro, Italy.
   [de Franciscis, Stefano; Serra, Raffaele] Magna Graecia Univ Catanzaro, Int Res & Educ Program Clin & Expt Biotechnol, Interuniv Ctr Phlebolymphol CIFL, Catanzaro, Italy.
C3 University of Messina; University Messina Policlin; Magna Graecia
   University of Catanzaro; Magna Graecia University of Catanzaro
RP Serra, R (通讯作者)，Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Viale Europa Germaneto, I-88100 Catanzaro, Italy.
EM rserra@unicz.it
RI ; Grande, Raffaele/AAO-1388-2020; De Caridi, Giovanni/KRQ-6363-2024;
   Serra, Raffaele/AAA-6874-2022; /AAM-9453-2020
OI Butrico, Lucia/0000-0002-0536-0705; Greco, Michele/0000-0001-5638-1613;
   Grande, Raffaele/0000-0003-2873-0104; de Franciscis,
   Stefano/0000-0001-9365-4609; De Caridi, Giovanni/0000-0002-1859-9010;
   Serra, Raffaele/0000-0003-4477-7412; 
CR [Anonymous], GUID MAN WOUNDS PAT
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
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   Hunter S, 2007, ADV SKIN WOUND CARE, V20, P90
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   Ulusal AE, 2011, ACTA ORTHOP TRAUMATO, V45, P254, DOI 10.3944/AOTT.2011.2283
   Veves A, 2001, DIABETES CARE, V24, P290, DOI 10.2337/diacare.24.2.290
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NR 21
TC 20
Z9 22
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2016
VL 13
IS 3
BP 336
EP 342
DI 10.1111/iwj.12301
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DR5JW
UT WOS:000379940300006
PM 24872149
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Srivastava, RN
   Dwivedi, MK
   Bhagat, AK
   Raj, S
   Agarwal, R
   Chandra, A
AF Srivastava, Rajeshwar N.
   Dwivedi, Mukesh K.
   Bhagat, Amit K.
   Raj, Saloni
   Agarwal, Rajiv
   Chandra, Abhijit
TI A non-randomised, controlled clinical trial of an innovative device for
   negative pressure wound therapy of pressure ulcers in traumatic
   paraplegia patients
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Out patient department procedure;
   Pressure ulcer; Traumatic paraplegia
ID VACUUM-ASSISTED CLOSURE; HISTORICAL-PERSPECTIVE
AB The conventional methods of treatment of pressure ulcers (PUs) by serial debridement and daily dressings require prolonged hospitalisation, associated with considerable morbidity. There is, however, recent evidence to suggest that negative pressure wound therapy (NPWT) accelerates healing. The commercial devices for NPWT are costly, cumbersome, and electricity dependent. We compared PU wound healing in traumatic paraplegia patients by conventional dressing and by an innovative negative pressure device (NPD). In this prospective, non-randomised trial, 48 traumatic paraplegia patients with PUs of stages 3 and 4 were recruited. Patients were divided into two groups: group A (n = 24) received NPWT with our NPD, and group B (n = 24) received conventional methods of dressing. All patients were followed up for 9weeks. At week 9, all patients on NPD showed a statistically significant improvement in PU healing in terms of slough clearance, granulation tissue formation, wound discharge and culture. A significant reduction in wound size and ulcer depth was observed in NPD as compared with conventional methods at all follow-up time points (P = 0.0001). NPWT by the innovative device heals PUs at a significantly higher rate than conventional treatment. The device is safe, easy to apply and cost-effective.
C1 [Srivastava, Rajeshwar N.; Dwivedi, Mukesh K.] King Georges Med Univ KGMU, Dept Orthopaed Surg, Lucknow, Uttar Pradesh, India.
   [Bhagat, Amit K.; Chandra, Abhijit] King Georges Med Univ KGMU, Dept Surg Gastroenterol, Lucknow, Uttar Pradesh, India.
   [Raj, Saloni] MS Ramiyah Med Coll, Bangalore, Karnataka, India.
   [Agarwal, Rajiv] King Georges Med Univ KGMU, Dept Plast Surg, Lucknow, Uttar Pradesh, India.
C3 King George's Medical University; King George's Medical University; King
   George's Medical University
RP Srivastava, RN (通讯作者)，King Georges Med Univ KGMU, Dept Orthopaed Surg, Lucknow, Uttar Pradesh, India.
EM drrnsrivastava@yahoo.com
FU Council of Science and Technology, Uttar Pradesh
FX The authors are thankful to Dr Divya Sanghi and Dr Rajendra P Mishra,
   and Ms Kavita Baghel for their kind support. They are also thankful to
   the Council of Science and Technology, Uttar Pradesh, for the financial
   assistance.
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NR 19
TC 10
Z9 12
U1 1
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2016
VL 13
IS 3
BP 343
EP 348
DI 10.1111/iwj.12309
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DR5JW
UT WOS:000379940300007
PM 24894079
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Mermerkaya, U
   Bekmez, S
   Alkan, E
   Ayvaz, M
   Tokgozoglu, M
AF Mermerkaya, Ugur
   Bekmez, Senol
   Alkan, Erkan
   Ayvaz, Mehmet
   Tokgozoglu, Mazhar
TI Evaluation of vacuum-assisted closure in patients with wound
   complications following tumour surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Musculoskeletal tumour; Negative pressure wound therapy; Soft-tissue
   reconstruction; Vacuum-assisted closure; Wound-related complication
ID SOFT-TISSUE SARCOMA; THERAPY; EXTREMITY; MANAGEMENT; DRESSINGS;
   FRACTURES; ULCERS; TRIAL; TIBIA; STATE
AB Covering the reconstructed area with a healthy soft-tissue envelope is a major challenge after limb-sparing surgery in patients with malignant bone and soft-tissue tumours. Negative pressure wound therapy (NPWT) of open wounds hastens healing and minimises the requirement for complex reconstructive soft-tissue surgery. The aim of this study was to investigate the effectiveness and safety of NPWT in bone and soft-tissue malignant tumour patients with postoperative wound complications. Between January 2006 and November 2009, at a single institution, 13 patients with malignant bone and soft-tissue tumours who had undergone wide resection were retrospectively analysed. NPWT was performed in all patients to temporarily close the soft-tissue defects. After obtaining the culture negativity and normal infection markers, definitive soft-tissue reconstruction was performed to close the wound with primary suturisation in two patients, split thickness grafts in four patients, full thickness grafts in two patients, rotational flaps in three patients and free flaps in two patients. Mean duration of hospitalisation was 20 (range 8-48) days andmean follow-up period was 57.3 (range 50-74) months. There was no tumour recurrence or skip metastasis in the follow-up period. In addition, there was no periprosthetic infection or complication associated with NPWT. In conclusion, NPWT therapy seems to be a safe and effective option in the management of local wound problems and secondary surgical site infections after musculoskeletal tumour surgery.
C1 [Mermerkaya, Ugur] Bozok Univ, Orthopaed & Traumatol Dept, Sch Med, Yozgat, Turkey.
   [Bekmez, Senol] Sami Ulus Hosp, Orthopaed & Traumatol Dept, Ankara, Turkey.
   [Alkan, Erkan] Yalvac State Hosp, Orthopaed & Traumatol Dept, Isparta, Turkey.
   [Ayvaz, Mehmet; Tokgozoglu, Mazhar] Hacettepe Univ, Orthopaed & Traumatol Dept, Sch Med, Ankara, Turkey.
C3 Bozok University; Dr. Sami Ulus Education & Research Hospital; Isparta
   Yalvac State Hospital; Hacettepe University
RP Mermerkaya, U (通讯作者)，Bozok Univ, Orthopaed & Traumatol Dept, Sch Med, Yozgat, Turkey.
EM drugurmermerkaya@gmail.com
RI Bekmez, Senol/M-4212-2014; Ayvaz, Mehmet/KBQ-6485-2024; Tokgozoglu,
   A./I-9693-2013; Alkan, Erkan/ABE-5381-2020
OI Alkan, Erkan/0000-0002-1131-5054
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   Senchenkov A, 2007, WORLD J SURG ONCOL, V29, P138
   Siegel HJ, 2007, J SURG ONCOL, V96, P575, DOI 10.1002/jso.20846
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NR 23
TC 8
Z9 10
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2016
VL 13
IS 3
BP 394
EP 397
DI 10.1111/iwj.12318
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DR5JW
UT WOS:000379940300014
PM 24976480
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Chen, Y
   Xu, SF
   Xu, M
   Yu, XC
AF Chen, Yu
   Xu, Song-Feng
   Xu, Ming
   Yu, Xiu-Chun
TI Use of negative pressure wound therapy as an adjunct to the treatment of
   extremity soft-tissue sarcoma with ulceration or impending ulceration
SO ONCOLOGY LETTERS
LA English
DT Article
DE soft-tissue sarcoma; surgery; negative pressure wound therapy;
   vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; RECONSTRUCTION; RESECTION; SURGERY;
   NERVE; COMPLICATIONS; INFECTION; TRIAL; FOOT
AB Major wound complications of the extremities, following wide tumor resection and reconstruction for soft-tissue sarcomas (STSs), remain a challenge for limb-sparing surgery. Furthermore, STSs with ulceration or impending ulceration predispose patients to an increased risk of post-operative infection. The present study was conducted to assess the efficacy of negative pressure wound therapy (NPWT) in preventing wound complications associated with surgical treatment of STSs with ulceration or impending ulceration, in patients treated between February 2012 and January 2013. A total of 5 patients, with a mean age of 48 years (range, 24-68 years), were enrolled in the present study. The diagnoses consisted of undifferentiated pleomorphic sarcoma (n=2), leiomyosarcoma (n=1), synovial sarcoma (n=1) and epithelioid sarcoma (n=1). According to American Joint Committee on Cancer criteria, 3 cases were stage III tumors, and the remaining 2 cases were of stages. A and. B, respectively. A total of 3 patients exhibited ulceration at diagnosis, and the remaining patients demonstrated impending ulceration. The mean wound area following wide resection of the tumor was 73 cm(2) (range, 45-110 cm(2)). A continuous suction mode, with pressures measuring -200 to -300 mmHg, was used for 7-10 days on the soft-tissue defects as preparation for wound closure. Soft-tissue reconstruction included muscle flaps (n=2) and skin grafts (n=5). No major wound complications occurred. Post-operative functional and cosmetic outcomes were acceptable. A single patient demonstrated local recurrence 12 months after surgery and re-excision of the tumor was performed. All patients remained alive at the conclusion of follow-up, with a mean follow-up time of 26 months (range, 12-36 months). The present study demonstrated that NPWT is effective and safe when used as an adjunct to wound closure following resection of extremity STS with ulceration/impending ulceration.
C1 [Chen, Yu; Xu, Song-Feng; Xu, Ming; Yu, Xiu-Chun] Jinan Mil Commanding Reg, Gen Hosp, Dept Orthoped Surg, 25 Shifan Rd, Jinan 250031, Shandong, Peoples R China.
RP Yu, XC (通讯作者)，Jinan Mil Commanding Reg, Gen Hosp, Dept Orthoped Surg, 25 Shifan Rd, Jinan 250031, Shandong, Peoples R China.
EM toeflmugou@163.com
RI Xu, Ming/JXX-3442-2024; Xu, SongFeng/AGF-0526-2022
OI Xu, SongFeng/0000-0003-3547-1796
CR Baldini EH, 2013, ANN SURG ONCOL, V20, P1494, DOI 10.1245/s10434-012-2797-1
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NR 33
TC 10
Z9 12
U1 0
U2 3
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-1074
EI 1792-1082
J9 ONCOL LETT
JI Oncol. Lett.
PD JUL
PY 2016
VL 12
IS 1
BP 757
EP 763
DI 10.3892/ol.2016.4654
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA DR5RN
UT WOS:000379960200123
PM 27347212
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Uchino, M
   Hirose, K
   Bando, T
   Chohno, T
   Takesue, Y
   Ikeuchi, H
AF Uchino, Motoi
   Hirose, Kei
   Bando, Toshihiro
   Chohno, Teruhiro
   Takesue, Yoshio
   Ikeuchi, Hiroki
TI Randomized Controlled Trial of Prophylactic Negative-Pressure Wound
   Therapy at Ostomy Closure for the Prevention of Delayed Wound Healing
   and Surgical Site Infection in Patients with Ulcerative Colitis
SO DIGESTIVE SURGERY
LA English
DT Article
DE Ostomy closure; Purse-string suture; Negative pressure wound therapy;
   Ulcerative colitis
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL CLOSURE; OPEN ABDOMEN; DISEASE;
   DEVICE
AB Background/Aims: Although negative-pressure wound therapy (NPWT) is likely advantageous for wound healing, the efficacy and safety of its prophylactic use remain unclear for digestive surgery. We performed a prospective randomized controlled study to evaluate the efficacy and safety of this procedure during ileostomy closure. Methods: We conducted a prospective, randomized study between November 2014 and September 2015. Patients with ulcerative colitis scheduled to undergo ileostomy closure with purse-string suture (PSS) were randomly divided into groups with or without NPWT. The primary endpoint was complete wound healing. The secondary endpoints were incidences of wound complications. Results: A total of 31 patients with PSS alone and 28 patients with PSS + NPWT were enrolled. Wound infection was observed in 1 patient in the PSS-alone condition and 3 patients in the PSS + NPWT condition (p = 0.76). The mean duration of complete wound healing was 37.6 +/- 11.7 days in the PSS-alone condition and 33.5 +/- 10.0 days in the PSS + NPWT condition (p = 0.18). Conclusion: Although no adverse effects were observed in this series, the efficacy of PSS + NPWT was not confirmed. Further clarification of the indication of prophylactic NPWT and its efficacy must be obtained, and the efficacy and safety of NPWT in different dirty/infected surgeries should be evaluated. (C) 2016 S. Karger AG, Basel.
C1 [Uchino, Motoi; Hirose, Kei; Bando, Toshihiro; Chohno, Teruhiro; Ikeuchi, Hiroki] Hyogo Coll Med, Dept Inflammatory Bowel Dis, Nishinomiya, Hyogo, Japan.
   [Takesue, Yoshio] Hyogo Coll Med, Dept Infect Control & Prevent, Nishinomiya, Hyogo, Japan.
C3 Hyogo Medical University; Hyogo Medical University
RP Uchino, M (通讯作者)，Hyogo Coll Med, Dept Surg, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan.
EM uchino2s@hyo-med.ac.jp
OI Takesue, Yoshio/0000-0002-8635-6416
CR Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
   Cheatham ML, 2013, WORLD J SURG, V37, P2018, DOI 10.1007/s00268-013-2080-z
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NR 16
TC 42
Z9 48
U1 2
U2 8
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0253-4886
EI 1421-9883
J9 DIGEST SURG
JI Dig. Surg.
PY 2016
VL 33
IS 6
BP 449
EP 454
DI 10.1159/000446550
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA DR8GR
UT WOS:000380136900001
PM 27246708
DA 2026-07-24
ER
PT J
AU Li, XC
   Cui, JL
   Maharjan, S
   Yu, X
   Lu, LJ
   Gong, X
AF Li, Xiucun
   Cui, Jianli
   Maharjan, Suraj
   Yu, Xin
   Lu, Laijin
   Gong, Xu
TI Neo-digit functional reconstruction of mutilating hand injury using
   transplantation of multiple composite tissue flaps
SO MEDICINE
LA English
DT Article
DE composite tissue flap transplantation; functional reconstruction;
   mutilating hand injury
ID VACUUM-ASSISTED CLOSURE; UPPER EXTREMITY; REPLANTATION; RELIABILITY;
   VALIDITY; DEFECTS; THERAPY; JOINT
AB Purpose: Functional reconstruction of mutilating hand injuries poses a challenge to the surgeon. We present our experience with use of multiple composite tissue flaps transplant for functional reconstruction of hand in patients with mutilating hand injuries. The associated merits and demerits of these surgical approaches are briefly discussed.
   Methods: From August 2004 to October 2014, functional reconstruction of hand with transplantation of multiple composite tissue flaps was performed in 8 patients. These included the toe with dorsal pedis artery flap, the reverse posterior interosseous artery flap, and the anterolateral thigh flap. Mean interval from injury to functional reconstruction was 10.6 days.
   Results: All transplanted skin flaps and reconstructed neofingers survived completely. Only 1 patient developed wound infection at the recipient site (hand), which resolved without any debridement or revision surgery. At the donor site (foot), partial skin necrosis was observed in 1 patient, which healed with local wound care. In other patients, all wounds healed without any complications. The average range of movement at the neofinger metacarpophalangeal and interphalangeal joints was 38 degrees and 73 degrees, respectively. None of the patients required revision surgery.
   Conclusion: Use of negative pressure wound therapy and multiple composite tissue flap transplantation appears to be an effective strategy for hand functional reconstruction in patients with mutilating hand injuries. Among the multiple composite tissue flaps, use of toe transplantation combined with reverse posterior interosseous artery flap appears to be the best option.
C1 [Li, Xiucun; Cui, Jianli; Maharjan, Suraj; Yu, Xin; Lu, Laijin; Gong, Xu] Jilin Univ, Hosp 1, Dept Hand & Foot Surg, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University
RP Lu, LJ; Gong, X (通讯作者)，Jilin Univ, Hosp 1, Dept Hand & Foot Surg, Changchun 130021, Jilin, Peoples R China.
EM triumphlixc@163.com; 13944099151@163.com
RI Li, xiucun/AAI-9002-2020
OI Li, xiucun/0000-0002-3260-6299
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NR 31
TC 5
Z9 8
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL
PY 2016
VL 95
IS 27
AR e4179
DI 10.1097/MD.0000000000004179
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DS1QW
UT WOS:000380372400088
PM 27399142
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Huang, CH
   Hsu, CC
   Chen, CPC
   Chow, SE
   Wang, JS
   Shyu, YC
   Lu, MJ
AF Huang, Ching-Hui
   Hsu, Chih-Chin
   Chen, Carl Pai-Chu
   Chow, Shu-Er
   Wang, Jong-Shyan
   Shyu, Yu-Chiau
   Lu, Mu-Jie
TI Negative pressure induces p120-catenin-dependent adherens junction
   disassembly in keratinocytes during wound healing
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
LA English
DT Article
DE Negative-pressure wound therapy; Wound healing; Cell movement;
   E-cadherin
ID COLLECTIVE CELL-MIGRATION; E-CADHERIN; P120 CATENIN; BETA-CATENIN;
   TYROSINE PHOSPHORYLATION; TIGHT JUNCTIONS; FIBRIN MATRIX; THERAPY;
   MECHANISMS; PROLIFERATION
AB A negative-pressure of 125 mm Hg (NP) has been widely used to treat chronic wounds in modern medicine. Keratinocytes under NP treatment have shown accelerated cell movement and decreased E-cadherin expression. However, the molecular mechanism of E-cadherin regulation under NP remains incompletely understood. Therefore, we investigated the E-cadherin regulation in keratinocytes (HaCaT cells) under NP. HaCaT cells were treated at ambient pressure (AP) and NP for 12 h. Cell movement was measured by traditional and electric wound healing assays at the 2 different pressures. Mutants with overexpression of p120-catenin (p120(ctn)) were used to observe the effect of NP on p120(ctn) and E-cadherin expression during wound healing. Cell fractionation and immunoblotting data showed that NP increased Y228-phosphorylated p120(ctn) level and resulted in the translocation of p120(ctn) from the plasma membrane to cytoplasm. Immunofluorescence images revealed that NP decreased the co-localization of p120(ctn) and E-cadherin on the plasma membrane. Knockdown of p120(ctn) reduced E-cadherin expression and accelerated cell movement under AP. Overexpression of the Y228-phosphorylation-mimic p120(ctn) decreased E-cadherin membrane expression under both AP and NP. Phosphorylation-deficient mutants conferred restored adherens junctions (AJs) under NP. The Src inhibitor blocked the phosphorylation of p120(ctn) and impeded cell migration under NP. In conclusion, Src-dependent phosphorylation of p120(ctn) can respond rapidly to NP and contribute to E-cadherin downregulation. The NP-induced disassembly of the AJ further accelerates wound healing. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Huang, Ching-Hui; Wang, Jong-Shyan] Chang Gung Univ, Grad Inst Rehabil Sci, Hlth Aging Res Ctr, Taoyuan, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Keelung, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan, Taiwan.
   [Chen, Carl Pai-Chu] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Chow, Shu-Er] Chang Gung Univ, Ctr Gen Studies, Taoyuan, Taiwan.
   [Shyu, Yu-Chiau; Lu, Mu-Jie] Chang Gung Mem Hosp, Community Med Res Ctr, Keelung, Taiwan.
   [Shyu, Yu-Chiau] Acad Sinica, Inst Mol Biol, Taipei, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Chang Gung University; Chang
   Gung Memorial Hospital; Academia Sinica - Taiwan
RP Hsu, CC (通讯作者)，Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Keelung, Taiwan.
EM steele0618@gmail.com
OI Lu, Mu-Jie/0000-0002-2174-1153; Wang, Jong-Shyan/0000-0002-3095-9357;
   Shyu, Yu-Chiau/0000-0003-1747-2226
FU Chang Gung Medical Research Program [CMRPG2E0141, CMRPG2D0031]; Ministry
   of Science and Technology in Taiwan [MOST 103-2314-B-182-003]
FX The study was funded by the Chang Gung Medical Research Program
   (CMRPG2E0141 and CMRPG2D0031) and the Ministry of Science and Technology
   in Taiwan (MOST 103-2314-B-182-003). We thank Mr. Hsiao-Tung Liu in the
   Laser Scanning Confocal Microscopy Room, Chang Gung Memorial Hospital,
   Keelung, for providing excellent fluorescent images. Dr. Chih-Yi Chien
   in Community Medicine Research Center, Chang Gung Memorial Hospital,
   Keelung, and Dr. Yu-Shien Lee in Department of Biotechnology, Ming Chuan
   University and Genomic Medicine Research Core Laboratory, Chang Gung
   Memorial Hospital, Linkou, Toyuan, contribute greatly to microarray data
   analysis.
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NR 32
TC 6
Z9 9
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-4889
EI 0006-3002
J9 BBA-MOL CELL RES
JI Biochim. Biophys. Acta-Mol. Cell Res.
PD SEP
PY 2016
VL 1863
IS 9
BP 2212
EP 2220
DI 10.1016/j.bbamcr.2016.05.017
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA DS2LI
UT WOS:000380600600007
PM 27220534
DA 2026-07-24
ER
PT J
AU Jung, JA
   Yoo, KH
   Han, SK
   Lee, YN
   Jeong, SH
   Dhong, ES
   Kim, WK
AF Jung, Jae-A.
   Yoo, Ki-Hyun
   Han, Seung-Kyu
   Lee, Ye-Na
   Jeong, Seong-Ho
   Dhong, Eun-Sang
   Kim, Woo-Kyung
TI Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in
   Diabetic Feet
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative-pressure wound therapy; tissue oxygenation; diabetic foot
ID MICROVASCULAR BLOOD-FLOW; VACUUM-ASSISTED CLOSURE; AMPUTATION;
   PERFUSION; ARTERIAL
AB OBJECTIVE: Negative-pressure wound therapy (NPWT) has become a common wound care treatment modality for a variety of wounds. Several previous studies have reported that NPWT increases blood flow in the wound bed. However, NPWT might decrease tissue oxygenation in the wound bed because the foam sponge of NPWT compresses the wound bed under the influence of the applied negative pressure. Adequate tissue oxygenation is an essential consideration during diabetic foot management, and the foot is more sensitive to ischemia than any other region. Furthermore, the issue as to whether NPWT reduces or increases tissue oxygenation in diabetic feet has never been correctly addressed. The aim of this study was to evaluate the influence of NPWT on tissue oxygenation in diabetic feet.
   PARTICIPANTS: Transcutaneous partial oxygen pressures (TcPO2) were measured to determine tissue oxygenation levels beneath NPWT dressings on 21 feet of 21 diabetic foot ulcer patients.
   DESIGN: A TcPO2 sensor was fixed at the tarsometatarsal area of contralateral unwounded feet. A suction pressure of -125 mm Hg was applied until TcPO2 reached a steady state. The TcPO2 values for diabetic feet were measured before, during, and after NPWT.
   MAIN RESULTS: The TcPO2 levels decreased significantly after applying NPWT in all patients. Mean TcPO2 values before, during, and after therapy were 44.6 (SD, 15.2), 6.0 (SD, 7.1), and 40.3 (SD, 16.4) mm Hg (P < .01), respectively.
   CONCLUSION: These results show that NPWT significantly reduces tissue oxygenation levels in diabetic foot.
C1 [Jung, Jae-A.; Yoo, Ki-Hyun; Han, Seung-Kyu; Lee, Ye-Na; Jeong, Seong-Ho; Dhong, Eun-Sang; Kim, Woo-Kyung] Korea Univ, Guro Hosp, Dept Plast Surg, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Han, SK (通讯作者)，Korea Univ, Guro Hosp, Dept Plast Surg, Seoul, South Korea.
OI Dhong, Eun Sang/0000-0002-7521-0518
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NR 25
TC 21
Z9 22
U1 1
U2 35
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2016
VL 29
IS 8
BP 364
EP 370
DI 10.1097/01.ASW.0000483038.18331.a4
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA DS2RL
UT WOS:000380631100006
PM 27429242
DA 2026-07-24
ER
PT J
AU Chow, SE
   Chen, CPC
   Hsu, CC
   Tsai, WC
   Wang, JS
   Hsu, NC
AF Chow, Shu-Er
   Chen, Carl Pai-Chu
   Hsu, Chih-Chin
   Tsai, Wen-Chung
   Wang, Jong-Shyan
   Hsu, Ning-Chun
TI Quantifying cell behaviors in negative-pressure induced monolayer cell
   movement
SO BIOMEDICAL JOURNAL
LA English
DT Article
DE Cell movement; Cytoskeleton; Intercellular junctions; Negative-pressure
   wound therapy; Wound healing
ID WOUND FIBRIN MATRIX; HYPERBARIC-OXYGEN; MIGRATION; PROLIFERATION;
   MECHANISMS; THERAPY; MODEL
AB Background: Negative-pressure of 125 mmHg (NP) has been shown to accelerate wound healing. Effects of NP on human keratinocyte behaviors during wound healing process were highlighted in this study.
   Methods: An NP incubator incorporating the electric cell-substrate impedance sensing (ECIS) technique has been built to quantify monolayer keratinocytes movement in serum-free media at the ambient pressure (AP) and NP for 12 h. Monolayer cell motions were continuously recorded by ECIS in the frequency range of 22.5-64 kHz. Membrane capacitance (C-m), cell-substratum resistance (alpha), and cell-cell junction resistance (R-b) were evaluated in cells at the different pressures.
   Results: A greater monolayer cell migration distance was found in cells at NP. Decreased cell-substratum adhesion reflected in the significantly low alpha (AP:NP = similar to 5 Omega(0.5):similar to 3 Omega(0.5), cm), decreased integrin expression, and increased cell-substratum distance were seen in cells at NP. A significantly increased C-m (AP:NP = similar to 4:similar to 8 mu F/cm(2)) in association with increased membrane ruffling and microtubule filaments were observed early in the monolayer cell movement at NP. A progressive drop in the R-b from 1.2 Omega.cm(2) to 0.8 Omega.cm(2) corresponding to the gradually decreased E-cadherin expressions were observed 6 h after wound closure after NP treatment.
   Conclusion: A quick membrane ruffling formation, an early cell-substratum separation, and an ensuing decrease in the cellular interaction occur in cells at NP. These specific monolayer cell behaviors at NP have been quantified and possibly accelerate wound healing.
C1 [Chow, Shu-Er] Chang Gung Univ, Ctr Gen Studies, Dept Nat Sci, Taoyuan, Taiwan.
   [Chen, Carl Pai-Chu] Chang Gung Mem Hosp Taipei, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Hsu, Chih-Chin; Hsu, Ning-Chun] Chang Gung Mem Hosp Keelung, Dept Phys Med & Rehabil, 222 Maijin Rd, Keelung, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan, Taiwan.
   [Tsai, Wen-Chung] Chang Gung Mem Hosp Linkou, Dept Phys Med & Rehabil, Taoyuan, Taiwan.
   [Wang, Jong-Shyan] Chang Gung Univ, Coll Med, Inst Rehabil Sci, Taoyuan, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung Memorial
   Hospital; Chang Gung University; Chang Gung Memorial Hospital; Chang
   Gung University
RP Hsu, CC (通讯作者)，Chang Gung Mem Hosp Keelung, Dept Phys Med & Rehabil, 222 Maijin Rd, Keelung, Taiwan.
EM steele0618@gmail.com
OI Wang, Jong-Shyan/0000-0002-3095-9357
FU Chang Gung Medical Research Program [CMRPG2A0361, CMRPG2B0471,
   CMRPG2D0031, CMRPG2C0381]; National Science Council
   [NSC100-2314-B-182-053-MY3]
FX We thank the Chang Gung Medical Research Program grants (CMRPG2A0361,
   CMRPG2B0471, CMRPG2D0031, and CMRPG2C0381) and our National Science
   Council grant (NSC100-2314-B-182-053-MY3) for support of our academic
   research. We also appreciate the excellent confocal microscopic images
   provided by Mr. Hsiao-Tung Liu in Laser Scanning Confocal Microscopic
   Room, Chang Gung Memorial Hospital, Keelung. Chun-Min Lo in Department
   of Biomedical Engineering, National Yang-Ming University, Taipei, has
   help us process the electrical wound healing assay data.
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NR 28
TC 9
Z9 11
U1 1
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2319-4170
EI 2320-2890
J9 BIOMED J
JI Biomed. J.
PD FEB
PY 2016
VL 39
IS 1
BP 50
EP 59
DI 10.1016/j.bj.2015.08.005
PG 10
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA DS3VK
UT WOS:000380710600006
PM 27105598
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Karlakki, SL
   Hamad, AK
   Whittall, C
   Graham, NM
   Banerjee, RD
   Kuiper, JH
AF Karlakki, S. L.
   Hamad, A. K.
   Whittall, C.
   Graham, N. M.
   Banerjee, R. D.
   Kuiper, J. H.
TI Incisional negative pressure wound therapy dressings (iNPWTd) in routine
   primary hip and knee arthroplasties A RANDOMISED CONTROLLED TRIAL
SO BONE & JOINT RESEARCH
LA English
DT Article
DE NPWT; iNPWTd; Incisional wound; TKA; THA; Wound complications
ID VACUUM-ASSISTED CLOSURE; ORTHOPEDIC-SURGERY; SURGICAL-SITE;
   SUBATMOSPHERIC PRESSURE; MANAGEMENT; INFECTION; REPLACEMENT; PREVENTION;
   GUIDELINES; DRAINAGE
AB Objectives
   Wound complications are reported in up to 10% hip and knee arthroplasties and there is a proven association between wound complications and deep prosthetic infections. In this randomised controlled trial (RCT) we explore the potential benefits of a portable, single use, incisional negative pressure wound therapy dressing (iNPWTd) on wound exudate, length of stay (LOS), wound complications, dressing changes and cost-effectiveness following total hip and knee arthroplasties.
   Methods
   A total of 220 patients undergoing elective primary total hip and knee arthroplasties were recruited into in a non-blinded RCT. For the final analysis there were 102 patients in the study group and 107 in the control group.
   Results
   An improvement was seen in the study (iNPWTd) group compared to control in all areas. Peak post-surgical wound exudate was significantly reduced (p = 0.007). Overall LOS reduction (0.9 days, 95% confidence interval (CI) -0.2 to 2.5) was not significant (p = 0.07) but there was a significant reduction in patients with extreme values of LOS in the iNPWTd group (Moses test, p = 0.003). There was a significantly reduced number of dressing changes (mean difference 1.7, 95% CI 0.8 to 2.5, p = 0.002), and a trend to a significant four-fold reduction in reported post-operative surgical wound complications (8.4% control; 2.0% iNPWTd, p = 0.06).
   Conclusions
   Based on the results of this RCT incisional negative pressure wound therapy dressings have a beneficial role in patients undergoing primary hip and knee arthroplasty to achieve predictable length of stay, especially to eliminate excessive hospital stay, and minimise wound complications.
C1 [Karlakki, S. L.; Hamad, A. K.; Whittall, C.; Graham, N. M.; Banerjee, R. D.; Kuiper, J. H.] Robert Jones & Agnes Hunt Orthopaed Hosp, NHS FT, Oswestry SY10 7AG, Shrops, England.
   [Karlakki, S. L.; Hamad, A. K.; Whittall, C.; Graham, N. M.; Banerjee, R. D.; Kuiper, J. H.] Robert Jones & Agnes Hunt Orthopaed Hosp, NHS FT, Arthroplasty Dept, Oswestry SY10 7AG, Shrops, England.
C3 Keele University; Keele University
RP Karlakki, SL (通讯作者)，Robert Jones & Agnes Hunt Orthopaed Hosp, NHS FT, Oswestry SY10 7AG, Shrops, England.; Karlakki, SL (通讯作者)，Robert Jones & Agnes Hunt Orthopaed Hosp, NHS FT, Arthroplasty Dept, Oswestry SY10 7AG, Shrops, England.
EM sudheer.karlakki@rjah.nhs.uk
RI Whittall, Catherine/AAW-8323-2021
OI Whittall, Catherine/0000-0003-4859-4293
FU Smith Nephew UK
FX The study was funded through a grant from Smith & Nephew UK, to cover
   the cost of NPWT dressings and data collection costs. C. Whitall
   declares she has received payment from Smith & Nephew for other work
   unrelated to this paper.
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   Walter CJ, 2012, BRIT J SURG, V99, P1185, DOI 10.1002/bjs.8812
   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
   Weiss A P, 1993, J Arthroplasty, V8, P285, DOI 10.1016/S0883-5403(06)80091-4
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   Zhou XH, 2005, BIOSTATISTICS, V6, P187, DOI 10.1093/biostatistics/kxi002
NR 58
TC 96
Z9 104
U1 0
U2 11
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2046-3758
J9 BONE JOINT RES
JI Bone Jt. Res.
PD AUG
PY 2016
VL 5
IS 8
BP 328
EP 337
DI 10.1302/2046-3758.58.BJR-2016-0022.R1
PG 10
WC Cell & Tissue Engineering; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Orthopedics
GA DS7IM
UT WOS:000380956800002
PM 27496913
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yoshimoto, A
   Inoue, T
   Fujisaki, M
   Morizumi, S
   Suematsu, Y
AF Yoshimoto, Akihiro
   Inoue, Takafumi
   Fujisaki, Masayuki
   Morizumi, Sei
   Suematsu, Yoshihiro
TI Efficacy of vacuum-assisted closure therapy on rehabilitation during the
   treatment for surgical site infection after cardiovascular surgery
SO GENERAL THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE VAC treatment; Rehabilitation; Cardiovascular surgery; Surgical site
   infection
ID STERNAL WOUND-INFECTION; CARDIAC-SURGERY; POSTSTERNOTOMY MEDIASTINITIS;
   OPEN PACKING
AB Surgical site infection (SSI) after cardiovascular procedures is a severe complication, potentially leading to high morbidity and mortality. In addition, during the treatment of SSI, rehabilitation is delayed, which can severely impair postoperative recovery. The aim of this study was to assess the effect of vacuum-assisted closure (VAC) therapy on rehabilitation during the treatment of SSI after cardiovascular surgery.
   From January 2008 to March 2015, 10 patients underwent VAC therapy for SSI after cardiovascular operations. The patient characteristics, duration of VAC therapy, time interval from the implementation of VAC to physical therapy (PT) (T1), ambulation (T2) and walking (T3), functional independent measure (FIM), and maximum consecutive walking capacity (MCWC) were retrospectively analyzed.
   Nine patients underwent mid-sternal incision and one patient underwent thoraco-abdominal incision. The mean time interval from the beginning of VAC therapy to PT, ambulation, and walking was 0.38 +/- A 0.50, 0.63 +/- A 0.71, and 1.38 +/- A 1.86 days, respectively. The average FIM was 84.5 +/- A 14.0 at the beginning of VAC therapy and 106.7 +/- A 18.5 at the end of VAC therapy (P = 0.000494). On average, MCWC was 52.3 +/- A 54.6 m at the installation of VAC therapy and 189.7 +/- A 152.8 m at the completion of VAC therapy (P = 0.0169). FIM and MCWC improvement rate was better in VAC group than non-VAC group although these data are not suitable for statistical analysis because of a small sample size.
   Although further studies are warranted, VAC therapy may have a role in facilitating rehabilitation and improving the prognosis of SSI cases after major cardiovascular operations.
C1 [Yoshimoto, Akihiro; Inoue, Takafumi; Fujisaki, Masayuki; Morizumi, Sei; Suematsu, Yoshihiro] Tsukuba Mem Hosp, Dept Cardiovasc Surg, 1187-299 Kaname, Tsukuba, Ibaraki 3002622, Japan.
RP Yoshimoto, A (通讯作者)，Tsukuba Mem Hosp, Dept Cardiovasc Surg, 1187-299 Kaname, Tsukuba, Ibaraki 3002622, Japan.
EM yoshimoto0401@hotmail.co.jp
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NR 15
TC 8
Z9 8
U1 0
U2 5
PU SPRINGER JAPAN KK
PI TOKYO
PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065,
   JAPAN
SN 1863-6705
EI 1863-6713
J9 GEN THORAC CARDIOVAS
JI Gen. Thorac. Cardiovasc. Surg.
PD AUG
PY 2016
VL 64
IS 8
BP 464
EP 469
DI 10.1007/s11748-016-0664-x
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA DS9BY
UT WOS:000381078400005
PM 27262459
DA 2026-07-24
ER
PT J
AU Scherrer, AU
   Bloemberg, G
   Zbinden, R
   Zinkernagel, AS
   Fuchs, C
   Frauenfelder, S
   Rancic, Z
   Mayer, D
   Hasse, B
AF Scherrer, Alexandra U.
   Bloemberg, Guido
   Zbinden, Reinhard
   Zinkernagel, Annelies S.
   Fuchs, Claudio
   Frauenfelder, Sandra
   Rancic, Zoran
   Mayer, Dieter
   Hasse, Barbara
CA VASGRA Cohort
TI Prosthetic Vascular Graft Infections: Bacterial Cultures from
   Negative-Pressure-Wound-Therapy Foams Do Not Improve Diagnostics
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; IDENTIFICATION; GROIN; ALGINATE; SYSTEM
AB We analyzed the diagnostic value of microorganisms cultured from negative-pressure-wound-therapy (NPWT) foam samples compared to that of microorganisms cultured from deep tissue samples from patients with vascular graft infections. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 58%, 86%, 81%, and 66%, respectively. The diagnostic value of microbiological cultures from NPWT foams was poor.
C1 [Scherrer, Alexandra U.; Zinkernagel, Annelies S.; Fuchs, Claudio; Frauenfelder, Sandra; Hasse, Barbara] Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland.
   [Bloemberg, Guido; Zbinden, Reinhard] Univ Zurich, Inst Med Microbiol, Zurich, Switzerland.
   [Rancic, Zoran; Mayer, Dieter] Univ Zurich, Univ Zurich Hosp, Cardiovasc Surg Clin, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University of Zurich; University Zurich Hospital
RP Scherrer, AU (通讯作者)，Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland.
EM alexandra.scherrer@usz.ch
RI Mayer, Dieter/E-7617-2011; Bloemberg, Guido/AAC-4914-2020; Hasse,
   Barbara/T-1054-2017; Zinkernagel, Annelies/F-1780-2017
OI Mayer, Dieter/0000-0001-5933-7749; Hasse, Barbara/0000-0001-7196-3734;
   Zinkernagel, Annelies/0000-0003-4700-1118
FU Swiss National Science Foundation [320030_144277/1, 32473B_163132/1];
   Vontobel Foundation; Rozalia Foundation; Swiss National Science
   Foundation (SNF) [32473B_163132, 320030_144277] Funding Source: Swiss
   National Science Foundation (SNF)
FX This work, including the efforts of Barbara Katharina Hasse, was funded
   by Swiss National Science Foundation (320030_144277/1). This work,
   including the efforts of Barbara Katharina Hasse, was funded by Swiss
   National Science Foundation (32473B_163132/1). This work, including the
   efforts of Barbara Katharina Hasse, was funded by Vontobel Foundation.
   This work, including the efforts of Barbara Katharina Hasse, was funded
   by Rozalia Foundation.
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NR 22
TC 8
Z9 9
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
EI 1098-660X
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD AUG
PY 2016
VL 54
IS 8
BP 2190
EP 2193
DI 10.1128/JCM.01102-16
PG 4
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA DT1YO
UT WOS:000381278200039
PM 27252462
OA Green Submitted, Green Accepted, Bronze
DA 2026-07-24
ER
PT J
AU Gillespie, BM
   Webster, J
   Ellwood, D
   Stapleton, H
   Whitty, JA
   Thalib, L
   Cullum, N
   Mahomed, K
   Chaboyer, W
AF Gillespie, Brigid M.
   Webster, Joan
   Ellwood, David
   Stapleton, Helen
   Whitty, Jennifer A.
   Thalib, Lukman
   Cullum, Nicky
   Mahomed, Kassam
   Chaboyer, Wendy
TI ADding negative pRESSure to improve healING (the DRESSING trial): a RCT
   protocol
SO BMJ OPEN
LA English
DT Article
ID SURGICAL SITE INFECTION; WOUND THERAPY; PREVALENCE SURVEY; HEALTH;
   COMPLICATIONS; OBESITY; IMPACT
AB Introduction: Obese women are more likely to develop a surgical site infection (SSI) following caesarean section (CS) than non-obese women. Negative pressure wound therapy (NPWT) is increasingly being used to reduce SSI with limited evidence for its effectiveness.
   Objectives: To determine the clinical and cost-effectiveness of using NPWT in obese women having elective and semiurgent CS.
   Methods and analysis: A multisite, superiority parallel pragmatic randomised controlled trial with an economic evaluation. Women with a body mass index (BMI) of >= 30, booked for elective and semiurgent CS at 4 Australian acute care hospitals will be targeted. A total of 2090 women will be enrolled. A centralised randomisation service will be used with participants block randomised to either NPWT or standard surgical dressings in a 1:1 ratio, stratified by hospital. The primary outcome is SSI; secondary outcomes include type of SSI, length of stay, readmission, wound complications and health-related quality of life. Economic outcomes include direct healthcare costs and cost-effectiveness, which will be evaluated using incremental cost per quality-adjusted life year gained. Data will be collected at baseline, and participants followed up on the second postoperative day and weekly from the day of surgery for 4 weeks. Outcome assessors will be masked to allocation. The primary statistical analysis will be based on intention-to-treat.
   Ethics and dissemination: Ethics approval has been obtained from the ethics committees of the participating hospitals and universities. The findings of the trial will be disseminated through peer-reviewed journals, national and international conference presentations.
C1 [Gillespie, Brigid M.] Griffith Univ, NHMRC Ctr Res Excellence Nursing, Ctr Hlth Practice Innovat HPI, Menzies Hlth Inst Qld, Gold Coast, Qld, Australia.
   [Webster, Joan] Royal Brisbane & Womens Hosp, Res Ctr Clin Nursing, Nathan, Qld, Australia.
   [Webster, Joan] Griffith Univ, Nathan, Qld, Australia.
   [Ellwood, David] Griffith Univ, Sch Med, Dept Obstet & Gynaecol, Nathan, Qld 4111, Australia.
   [Ellwood, David] Gold Coast Univ Hosp, Maternal Fetal Med, Southport, Qld, Australia.
   [Stapleton, Helen] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
   [Whitty, Jennifer A.] Univ Queensland, Dept Hlth Econ Pharmacoecon & Qual Use Med, Sch Pharm, Brisbane, Qld, Australia.
   [Thalib, Lukman] Qatar Univ, Dept Hlth Sci, Coll Arts & Sci, Doha, Qatar.
   [Cullum, Nicky] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Mahomed, Kassam] West Moreton Hosp & Hlth Serv, Ipswich, Qld, Australia.
   [Chaboyer, Wendy] Griffith Univ, Menzies Hlth Inst Qld, NHMRC Ctr Res Excellence Nursing, Gold Coast, Qld, Australia.
C3 Griffith University; Menzies Health Institute Queensland; Royal Brisbane
   & Women's Hospital; Griffith University; Griffith University; Gold Coast
   University Hospital; University of Queensland; Mater Research;
   University of Queensland; Qatar University; University of Manchester;
   Menzies Health Institute Queensland; Griffith University
RP Gillespie, BM (通讯作者)，Griffith Univ, NHMRC Ctr Res Excellence Nursing, Ctr Hlth Practice Innovat HPI, Menzies Hlth Inst Qld, Gold Coast, Qld, Australia.
EM b.gillespie@griffith.edu.au
RI Whitty, Jennifer/N-6434-2013; Chaboyer, Wendy/F-9588-2018; Cullum,
   Nicky/F-2438-2011; Ellwood, David/C-8208-2015; Thalib,
   Lukman/HAI-7553-2022; Gillespie, Brigid/E-7799-2012; Mahomed,
   Kassam/M-1335-2013
OI Chaboyer, Wendy/0000-0001-9528-7814; Cullum, Nicky/0000-0003-2631-123X;
   Ellwood, David/0000-0003-4512-6443; Thalib, Lukman/0000-0002-1211-6495;
   Gillespie, Brigid/0000-0003-3186-5691; 
FU Australian National Health & Medical Research Project Grant [APP1081026]
FX This trial is funded through an Australian National Health & Medical
   Research Project Grant (APP1081026).
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NR 25
TC 11
Z9 12
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2016
VL 6
IS 2
AR e010287
DI 10.1136/bmjopen-2015-010287
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DT5HX
UT WOS:000381514500113
PM 26832435
OA Green Accepted, Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Bukovcan, P
   Koller, J
   Hajská, M
   Záhorec, P
AF Bukovcan, Peter
   Koller, Jan
   Hajska, Marianna
   Zahorec, Peter
TI Clinical Experience With the Use of Negative Pressure Wound Therapy
   Combined With a Silver-impregnated Dressing in Mixed Wounds: A
   Retrospective Study of 50 Cases
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; silver-impregnated dressing; wound
   healing
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; OUTCOMES
AB Introduction. Although negative pressure wound therapy,(NPWT) has been used for more than 20 years, as far as the authors are aware, there is little research aimed at the evaluation of the combination of NPWT with a silver-impregnated dressing. Objective. The aim of this study was to examine the effect, efficacy, and safety of NPWT in conjunction with a silver-impregnated dressing. Materials and Methods. The authors used a retrospective study of 54 acute and chronic wounds treated in 50 patients over a 2-year period. Demographic data, wound characterizations, wound cultures before and after NPWT, the duration of NPWT and number of sponge changes-for each patient, the types of surgical procedures used for wound closure following NPWT, and the healing time and length of hospital stays were recorded. Results. In 26 wounds, deep structures (ie, bones and tendons) were exposed. The mean NPWT duration was 9.2 days. Mean healing time was 16 days. There was a statistically significant decrease in the pathogenic microbial strains after NPWT treatment combined with the silver-impregnated dressing (paired t test; P = 0.0038). The shift from complicated to, easier surgical wound-closure-procedures was observed. Discussion. According to all results obtained, described, and discussed, the authors consider the use of a nonadherent silver-impregnated. dressing in conjunction with: NPWT to be beneficial, and efficacious. No adverse events or reactions related to the silver-impregnated contact layer used during NPWT have been observed in the patients, which confirmed the safety of this method.
C1 [Bukovcan, Peter] Comenius Univ, Dept Burns & Reconstruct Surg, Bratislava, Slovakia.
   [Bukovcan, Peter] Univ Hosp Ruzinov, Bratislava, Slovakia.
C3 Comenius University Bratislava
RP Bukovcan, P (通讯作者)，Comenius Univ, Dept Burns & Reconstruct Surg, Bratislava, Slovakia.; Bukovcan, P (通讯作者)，Univ Hosp Ruzinov, Bratislava, Slovakia.
EM bukovcanmed@gmail.com
OI Hajská, Marianna/0000-0002-0822-8929; Bukovcan,
   Peter/0000-0003-2877-932X
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NR 20
TC 4
Z9 5
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2016
VL 28
IS 8
BP 255
EP 263
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DT7FB
UT WOS:000381651400004
PM 27560468
DA 2026-07-24
ER
PT J
AU Munakata, H
   Murakami, Y
   Mabuni, K
   Tsuchiya, H
   Shinzato, M
   Umemura, T
   Kugai, T
AF Munakata, Hiroshi
   Murakami, Yu
   Mabuni, Katsuhito
   Tsuchiya, Hiroyuki
   Shinzato, Moriaki
   Umemura, Takehiro
   Kugai, Tadao
TI Successful surgical treatment of traumatic sternal fracture with
   extensive mediastinal abscess and concomitant mitral valve endocarditis:
   a case report
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Traumatic sternal fracture; Mediastinitis; Endocarditis; Aggressive
   debridement; Successfully staged strategy
ID OSTEOMYELITIS; SURGERY
AB Background: A traumatic sternal fracture with extensive mediastinal abscess and concomitant native valve endocarditis is an extremely rare but catastrophic situation.
   Case presentation: For 2 weeks, the co-infected patient was treated with aggressive debridement for the mediastinitis, change of vacuum-assisted closure therapy dressings, vegetectomy and valve repair through lower partial sternotomy, and delayed primary wound closure.
   Conclusions: To the best of our knowledge, this successful staged strategy has not been previously reported. We believe that our quick decision about repeated surgical interventions and preservation of the manubrium led to a favorable result.
C1 [Munakata, Hiroshi; Murakami, Yu; Mabuni, Katsuhito; Kugai, Tadao] Okinawa Prefectural Nambu Med Ctr, Dept Cardiovasc Surg, Haebaru, Japan.
   [Munakata, Hiroshi; Murakami, Yu; Mabuni, Katsuhito; Tsuchiya, Hiroyuki; Shinzato, Moriaki; Umemura, Takehiro; Kugai, Tadao] Childrens Med Ctr, Haebaru, Japan.
   [Tsuchiya, Hiroyuki; Shinzato, Moriaki; Umemura, Takehiro] Okinawa Prefectural Nambu Med Ctr, Dept Emergency & Crit Care Med, Haebaru, Japan.
RP Munakata, H (通讯作者)，Okinawa Prefectural Nambu Med Ctr, Dept Cardiovasc Surg, Haebaru, Japan.; Munakata, H (通讯作者)，Childrens Med Ctr, Haebaru, Japan.
EM h-munakata@k7.dion.ne.jp
CR Ann JY, 2013, INTERNAL MED, V52, P511, DOI 10.2169/internalmedicine.52.8958
   Athanassiadi Kalliopi A, 2009, Thorac Surg Clin, V19, P37, DOI 10.1016/j.thorsurg.2008.09.012
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   Velissaris Theodore, 2002, Eur J Cardiothorac Surg, V22, P439, DOI 10.1016/S1010-7940(02)00335-4
NR 13
TC 1
Z9 1
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD AUG 15
PY 2016
VL 11
AR 134
DI 10.1186/s13019-016-0507-y
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA DT7QU
UT WOS:000381682100001
PM 27528381
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hakim, S
   Ahmed, K
   El-Menyar, A
   Jabbour, G
   Peralta, R
   Nabir, S
   Mekkodathil, A
   Abdelrahman, H
   Al-Hassani, A
   Al-Thani, H
AF Hakim, Suhail
   Ahmed, Khalid
   El-Menyar, Ayman
   Jabbour, Gaby
   Peralta, Ruben
   Nabir, Syed
   Mekkodathil, Ahammed
   Abdelrahman, Husham
   Al-Hassani, Ammar
   Al-Thani, Hassan
TI Patterns and management of degloving injuries: a single national level 1
   trauma center experience
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Degloving; Soft tissue injury; Debridement; Management; Trauma
ID VACUUM-ASSISTED CLOSURE; MOREL-LAVALLEE LESION
AB Background: Degloving soft tissue injuries (DSTIs) are serious surgical conditions. We aimed to evaluate the pattern, management and outcome of DSTIs in a single institute.
   Methods: A retrospective analysis was performed for patients admitted with DSTIs from 2011 to 2013. Presentation, management and outcomes were analyzed according to the type of DSTI.
   Results: Of 178 DSTI patients, 91 % were males with a mean age of 30.5 +/- 12.8. Three-quarter of cases was due to traffic-related injuries. Eighty percent of open DSTI cases were identified. Primary debridement and closure (62.9 %) was the frequent intervention used. Intermediate closed drainage under ultrasound guidance was performed in 7 patients; however, recurrence occurred in 4 patients who underwent closed serial drainage for recollection and ended with a proper debridement with or without vacuum assisted closure (VAC). Closed DSTIs were mainly seen in the lower extremity and back region and initially treated with conservative management as compared to open DSTIs. Infection and skin necrosis were reported in 9 cases only. Open DSTIs were more likely involving head and neck region and being treated by primary debridement/suturing and serial debridement/washout with or without VAC. All-cause DSTI mortality was 9 % that was higher in the closed DSTIs (19.4 vs 6.3 %; p = 0.01).
   Conclusion: The incidence of DSTIs is 4 % among trauma admissions over 3 years, with a greater predilection to males and young population. DSTIs are mostly underestimated particularly in the closed type that are usually missed at the initial presentation and associated with poor outcomes. Treatment guidelines are not well established and therefore further studies are warranted.
C1 [Hakim, Suhail; Ahmed, Khalid; Jabbour, Gaby; Peralta, Ruben; Abdelrahman, Husham; Al-Hassani, Ammar; Al-Thani, Hassan] Hamad Gen Hosp, Trauma Surg Sect, Doha, Qatar.
   [El-Menyar, Ayman; Mekkodathil, Ahammed] Hamad Gen Hosp, Trauma Surg Sect, Clin Res, Doha, Qatar.
   [El-Menyar, Ayman] Weill Cornell Med Coll, Clin Med, Doha, Qatar.
   [Nabir, Syed] Hamad Gen Hosp, Dept Radiol, Doha, Qatar.
C3 Hamad Medical Corporation; Hamad General Hospital; Hamad Medical
   Corporation; Hamad General Hospital; Qatar Foundation (QF); Weill
   Cornell Medical College Qatar; Hamad Medical Corporation; Hamad General
   Hospital
RP El-Menyar, A (通讯作者)，Hamad Gen Hosp, Trauma Surg Sect, Clin Res, Doha, Qatar.; El-Menyar, A (通讯作者)，Weill Cornell Med Coll, Clin Med, Doha, Qatar.
EM aymanco65@yahoo.com
RI Mekkodathil, Ahammed Abdulla/E-9629-2018; El-Menyar, Ayman/F-6734-2015;
   Peralta, Ruben/Y-4605-2018
OI Mekkodathil, Ahammed Abdulla/0000-0001-8431-8937; El-Menyar,
   Ayman/0000-0003-2584-953X; AHMED, KHALID/0000-0003-3576-0555; Peralta,
   Ruben/0000-0003-2817-0194
CR Antoniou D., 2005, Eur. J. Trauma, V31, P593, DOI DOI 10.1007/S00068-005-1059-3
   Dini M, 2012, INJURY, V43, P957, DOI 10.1016/j.injury.2011.03.020
   El-Menyar A, 2015, TRAFFIC INJ PREV, V13, P1
   Gilbert BC, 2004, AM J ROENTGENOL, V182, P1347, DOI 10.2214/ajr.182.5.1821347
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   Morris Melanie, 2009, J Trauma, V67, pE121, DOI 10.1097/TA.0b013e31803420be
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   Yan HD, 2013, J TRAUMA ACUTE CARE, V74, P604, DOI 10.1097/TA.0b013e31827d5e00
NR 20
TC 24
Z9 37
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JUL 27
PY 2016
VL 11
AR 35
DI 10.1186/s13017-016-0093-2
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA DT8OY
UT WOS:000381751800001
PM 27468300
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yang, RH
   Wang, ZJ
   Huang, WZ
   Zhao, YH
   Xu, LS
   Yu, SB
AF Yang, Ronghua
   Wang, Zhijun
   Huang, Wenzhu
   Zhao, Yuhuan
   Xu, Lusheng
   Yu, Shaobin
TI A Suitable Option for Gustilo and Anderson Grade III Injury
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE General Surgery; Internal Medicine; Vacuum drainage (VSD)
ID NEGATIVE-PRESSURE THERAPY; TIBIAL SHAFT FRACTURES; SOFT-TISSUE DEFECTS;
   LOWER-EXTREMITIES; WOUND THERAPY; RECONSTRUCTION; DEBRIDEMENT;
   MANAGEMENT; INFECTION
AB Background: The management of Gustilo and Anderson grade III injury remains difficult, particularly due to the incidence of wound infections, delayed fracture union, and traumatic extremity amputation. However, little data is available on delayed skin graft or flap reconstructions of Gustilo grade III injury, especially using new technologies of wound coverage, such as vacuum sealing drainage (VSD) combined with limited internal and/or external fixation.
   Material/Methods: Between June 2008 and May 2013, we performed the VSD technique combined with limited internal and/or external fixation on 38 patients (22 males and 16 females, with a mean age of 36.5 years) with Gustilo and Anderson grade III injury. VSD was regularly changed and delayed skin grafts or flaps were used to cover the defect. Two patients were lost to follow-up, and the remaining 36 were available for evaluation. The complications, wound healing, infections, and bony union were assessed for a mean duration of 2.5 years (range, 1-4 years).
   Results: Complications were seen in 5 of the 36 cases: 2 cases had infection alone, 1 case had delayed union or nonunion, 1 case had infection and delayed union, and 1 case had wound necrosis, infection, and nonunion. VSD was regularly changed 2-6 times. Morphological appearance and functional recovery were satisfactory in all cases.
   Conclusions: Using VSD before skin grafts or flaps coverage, combined with limited internal and/or external fixation, is a suitable option for Gustilo and Anderson grade III injury.
C1 [Yang, Ronghua] First Peoples Hosp Foshan, Dept Burn & Plast Surg, Foshan, Guangdong, Peoples R China.
   [Wang, Zhijun; Huang, Wenzhu] First Peoples Hosp Foshan, Dept Rehabil Med, Foshan, Guangdong, Peoples R China.
   [Zhao, Yuhuan] First Peoples Hosp Foshan, Dept Internal Med, Foshan, Guangdong, Peoples R China.
   [Xu, Lusheng; Yu, Shaobin] First Peoples Hosp Foshan, Dept Hand & Foot Plast Surg, Foshan, Guangdong, Peoples R China.
RP Yu, SB (通讯作者)，First Peoples Hosp Foshan, Dept Hand & Foot Plast Surg, Foshan, Guangdong, Peoples R China.
EM 1215601309@qq.com
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
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NR 21
TC 6
Z9 9
U1 0
U2 8
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD AUG 26
PY 2016
VL 22
DI 10.12659/MSM.896009
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DU2FR
UT WOS:000382027100002
PM 27564219
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hicks, CW
   Poruk, KE
   Baltodano, PA
   Soares, KC
   Azoury, SC
   Cooney, CM
   Cornell, P
   Eckhauser, FE
AF Hicks, Caitlin W.
   Poruk, Katherine E.
   Baltodano, Pablo A.
   Soares, Kevin C.
   Azoury, Said C.
   Cooney, Carisa M.
   Cornell, Peter
   Eckhauser, Frederic E.
TI Long-term outcomes of sandwich ventral hernia repair paired with hybrid
   vacuum-assisted closure
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Complex ventral hernia repair; Sandwich; Abdominal wall reconstruction;
   Negative pressure wound therapy; Vacuum-assisted closure; VAC
ID DERMAL COLLAGEN IMPLANT; COMPONENTS SEPARATION TECHNIQUE; TENSION-FREE
   RECONSTRUCTION; SURGICAL SITE OCCURRENCE; ABDOMINAL-WALL DEFECTS;
   POLYPROPYLENE MESH; EXPERIENCE; MANAGEMENT
AB Background: Sandwich ventral hernia repair (SVHR) may reduce ventral hernia recurrence rates, although with an increased risk of surgical site occurrences (SSOs) and surgical site infections (SSIs). Previously, we found that a modified negative pressure wound therapy (hybrid vacuum-assisted closure [HVAC]) system reduced SSOs and SSIs after ventral hernia repair. We aimed to describe our outcomes after SVHR paired with HVAC closure.
   Methods: We conducted a 4-y retrospective review of all complex SVHRs (biologic mesh underlay and synthetic mesh overlay) with HVAC closure performed at our institution by a single surgeon. All patients had fascial defects that could not be reapproximated primarily using anterior component separation. Descriptive statistics were used to report the incidence of postoperative complications and hernia recurrence.
   Results: A total of 60 patients (59.3 +/- 11.4 y, 58.3% male, 75% American Society of Anesthesiologists class >= 3) with complex ventral hernias being underwent sandwich repair with HVAC closure. Major postoperative morbidity (Dindo-Clavien class >= 3) occurred in 14 (23.3%) patients, but incidence of SSO (n = 13, 21.7%) and SSI (n = 4, 6.7%) was low compared with historical reports. Median follow-up time for all patients was 12 mo (interquartile range 5.8-26.5 mo). Hernia recurrence occurred in eight patients (13.3%) after a median time of 20.6 months (interquartile range 16.4-25.4 months).
   Conclusions: Use of a dual layer sandwich repair for complex abdominal wall reconstruction is associated with low rates of hernia recurrence at 1 year postoperatively. The addition of the HVAC closure system may reduce the risk of SSOs and SSIs previously reported with this technique and deserves consideration in future prospective studies assessing optimization of ventral hernia repair approaches. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Hicks, Caitlin W.; Poruk, Katherine E.; Baltodano, Pablo A.; Soares, Kevin C.; Azoury, Said C.; Cooney, Carisa M.; Cornell, Peter; Eckhauser, Frederic E.] Johns Hopkins Univ, Sch Med, Dept Surg, 600 N Wolfe St,Blalock 618, Baltimore, MD 21287 USA.
C3 Johns Hopkins University
RP Eckhauser, FE (通讯作者)，Johns Hopkins Univ, Sch Med, Dept Surg, 600 N Wolfe St,Blalock 618, Baltimore, MD 21287 USA.
EM feckhau2@jhmi.edu
RI Hicks, Caitlin/JAX-4080-2023; Soares, Kevin/PII-7807-2026
OI Hicks, Caitlin/0000-0001-7638-1936; 
FU KCI
FX This study was made possible in part through an investigator initiated
   trial grant from KCI to Dr Frederic Eckhauser. The other authors have no
   relevant disclosures.
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NR 27
TC 11
Z9 11
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD AUG
PY 2016
VL 204
IS 2
BP 282
EP 287
DI 10.1016/j.jss.2016.04.072
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DU5CP
UT WOS:000382230100003
PM 27565062
DA 2026-07-24
ER
PT J
AU Wang, ZH
   Qu, WQ
   Liu, T
   Zhou, ZY
   Zhao, ZY
   Wang, D
   Cheng, LM
AF Wang, Zhenhai
   Qu, Wenqing
   Liu, Tong
   Zhou, Zhiyong
   Zhao, Zhongyuan
   Wang, Dan
   Cheng, Limin
TI A Two-Stage Protocol With Vacuum Sealing Drainage for the Treatment of
   Type C Pilon Fractures
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE anteromedial incision; pilon fracture; staged surgery; tibia; vacuum
   seal
ID TIBIAL PLAFOND FRACTURES; INTERNAL-FIXATION; OPERATIVE TREATMENT; OPEN
   REDUCTION
AB Management of type C pilon fractures remains controversial and challenging. The aim of the present study was to provide a 2-stage protocol with vacuum sealing drainage for the treatment of type C pilon fractures. From March 2009 to March 2012, 16 patients (mean age 42.3 years) were admitted to our department with type C pilon fractures and treated with single-stage external fixation and second-stage internal fixation (anteromedial incision) combined with vacuum sealing drainage. The American Orthopaedic Foot and Ankle Society scale score averaged 86.5 for this group of patients. The range of motion was 30 degrees +/- 8.9 degrees. An excellent or good American Orthopaedic Foot and Ankle Society scale score was obtained for all patients. None of the 16 patients developed skin necrosis, nonunion, or fixation failure during the follow-up period. Moreover, the visual analog scale pain scores were 0.7 +/- 0.8, 0.9 +/- 0.7, and 1.4 +/- 1.0 during rest, active movement, and weightbearing, respectively. The postoperative radiographs showed excellent treatment effects. A 2-stage protocol, combined with vacuum sealing drainage, for the treatment of type C pilon fractures can eliminate deep infection and complex surgery and is a simple and effective treatment method. In addition, full exposure of the anteromedial incision, the avoidance of the anterior tibial muscle tendon sheath, and the avoidance of soft tissue injuries are generally recommended in this operation. (C) 2016 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Wang, Zhenhai; Qu, Wenqing; Liu, Tong; Zhou, Zhiyong; Zhao, Zhongyuan; Wang, Dan; Cheng, Limin] Yantaishan Hosp, Dept Orthopaed & Trauma, Yantai, Peoples R China.
   [Wang, Zhenhai; Qu, Wenqing; Liu, Tong; Zhou, Zhiyong; Zhao, Zhongyuan; Wang, Dan; Cheng, Limin] Yantai Sino French Friendship Hosp, Dept Orthopaed & Trauma, Yantai, Peoples R China.
RP Wang, ZH (通讯作者)，Yantai Sino French Friendship Hosp, Dept Orthopaed & Trauma, Yantaishan Hosp, Yantai 264000, Peoples R China.
EM ytzhenhai@163.com
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NR 20
TC 16
Z9 24
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD SEP-OCT
PY 2016
VL 55
IS 5
BP 1117
EP 1120
DI 10.1053/j.jfas.2016.01.047
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA DU5MY
UT WOS:000382257000050
PM 26994675
DA 2026-07-24
ER
PT J
AU Deng, W
   Boey, J
   Chen, B
   Byun, S
   Lew, E
   Liang, Z
   Armstrong, DG
AF Deng, W.
   Boey, J.
   Chen, B.
   Byun, S.
   Lew, E.
   Liang, Z.
   Armstrong, D. G.
TI Platelet-rich plasma, bilayered acellular matrix grafting and negative
   pressure wound therapy in diabetic foot infection
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE wound healing; diabetic foot; platelet-rich plasma; bilayered acellular
   matrix grafting; negative pressure wound therapy
ID NECROTIZING FASCIITIS; OSTEOMYELITIS; MANAGEMENT; GEL; LEUKOCYTE; RISK;
   PART
AB Management and treatment of acute severe diabetic foot disease in patients with suboptimal glycaemic control is a critical issue in wound repair. This paper discusses the clinical efficacy of an aggressive surgical intervention combined with targeted use of regenerative medical therapies in limb preservation. Negative pressure wound therapy (NPWT), platelet-rich plasma (PRP), bilayered acellular matrix grafting and split-thickness skin grafting were combined to treat a patient with diabetes, foot necrotising fasciitis and gaseous gangrene. The wound was completely healed. The clinical outcome revealed that a multi-intervention strategy could be effective for large necrotising fasciitis wounds. Early clinical observation, suggests aggresive surgical intervention preserving intact tissue and targeted use of new regenerative technologies can lead to preservation of a limb.
C1 [Deng, W.; Chen, B.; Liang, Z.] Third Mil Med Univ, Diabet Foot Ctr, Southwest Hosp, Dept Endocrinol, Chongqing, Peoples R China.
   [Boey, J.] Singapore Gen Hosp, Dept Podiatry, Singapore, Singapore.
   [Byun, S.; Lew, E.; Armstrong, D. G.] Univ Arizona, Hlth Sci Ctr, Dept Surg, SALSA, Tucson, AZ 85721 USA.
C3 Army Medical University; Singapore General Hospital; University of
   Arizona Health Sciences; University of Arizona
RP Armstrong, DG (通讯作者)，Univ Arizona, Hlth Sci Ctr, Dept Surg, SALSA, Tucson, AZ 85721 USA.
EM armstrong.dg@gmail.com
RI Boey, Johnson/AAR-2853-2020
OI Boey, Johnson/0000-0001-9466-7241
CR Alsousou J, 2009, J BONE JOINT SURG BR, V91B, P987, DOI 10.1302/0301-620X.91B8.22546
   [Anonymous], EVIDENCE BASED COMPL
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NR 26
TC 31
Z9 40
U1 0
U2 19
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2016
VL 25
IS 7
BP 393
EP 397
DI 10.12968/jowc.2016.25.7.393
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DU8HP
UT WOS:000382454200004
PM 27410393
DA 2026-07-24
ER
PT J
AU Choi, K
   Cho, J
   Park, M
   Park, DH
   Lee, IJ
AF Choi, KyeongBeom
   Cho, JaeHo
   Park, MyongChul
   Park, Dong Ha
   Lee, Il Jae
TI Knee and Ankle Reconstruction With Reverse Anterolateral Thigh and Free
   Anterolateral Thigh Flap From One Donor Site
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article; Proceedings Paper
CT 5th World Union of Wound-Healing-Societies (WUWHS)
CY SEP 25-29, 2016
CL Florence, ITALY
SP Wound Healing Soc
DE free tissue flaps; perforator flap; reconstructive surgical procedures;
   surgical flaps
ID PERFORATOR FLAP
AB Traditionally, the anterolateral thigh (ALT) free flap is used in distal lower extremity reconstruction. Reverse ALT flap has become one of the most popular choices for knee joint soft tissue defects. A 53-year-old man sustained a degloving injury in the right lateral side of the lower extremity from the lateral malleolar area to the knee joint area. The contamination was severe, necessitating serial debridement and negative pressure wound therapy. After 4 weeks, no more soft tissue necrosis was evident. No more microorganism growth was confirmed by swab culture. ALT free flap using proximal perforator was planned for lateral malleolar area reconstruction and reverse ALT flap using distal perforator was planned to cover knee joint after confirming the pedicle length was sufficient for simultaneous knee and lateral malleolar area reconstruction.
C1 [Choi, KyeongBeom; Park, MyongChul; Park, Dong Ha; Lee, Il Jae] Ajou Univ, Sch Med, Dept Plast & Reconstruct Surg, Worldcup Ro 164, Suwon 443721, Gyeonggi Do, South Korea.
   [Cho, JaeHo] Ajou Univ, Sch Med, Dept Orthoped Surg, Suwon, South Korea.
C3 Ajou University; Ajou University
RP Lee, IJ (通讯作者)，Ajou Univ, Sch Med, Dept Plast & Reconstruct Surg, Worldcup Ro 164, Suwon 443721, Gyeonggi Do, South Korea.
EM i00325@live.co.kr
CR Bibbo C, 2015, J ORTHOP TRAUMA, V29, P563, DOI 10.1097/BOT.0000000000000357
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NR 12
TC 2
Z9 2
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2016
VL 15
IS 3
BP 267
EP 270
DI 10.1177/1534734616653210
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Dermatology; Surgery
GA DU9ZP
UT WOS:000382577100013
PM 27317019
DA 2026-07-24
ER
PT J
AU Lippens, S
   Furcas, A
   Or, M
   Van Goethem, B
   Polis, I
   de Rooster, H
AF Lippens, S.
   Furcas, A.
   Or, M.
   Van Goethem, B.
   Polis, I.
   de Rooster, H.
TI Treatment of a chronic skin wound in a dog, using negative pressure
   wound therapy
SO VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
LA Dutch
DT Article
ID VACUUM-ASSISTED CLOSURE; EXTREMITY WOUNDS; MANAGEMENT; GRAFTS; DEVICE
AB A four-year-and-eight-month-old whippet was presented with a chronic skin wound situated at the medial aspect of the right elbow. Because of its chronic nature, the wound was initially carefully debrided and subsequently treated by means of negative pressure therapy. This fairly new technique offers a wide range of advantages that improve the healing capacities of a chronic wound. The beneficial effect of negative pressure wound therapy on the development of a nice granulation bed was clear. In order to optimize the final result, an autologous skin grafting (full-thickness free mesh graft) was performed. By applying negative pressure on the skin graft, a quick and solid attachment of the graft was achieved. After a period of four weeks, the wound was almost completely healed despite various earlier attempts to successfully treat that wound in the two-months period prior to referral.
C1 [Lippens, S.; Furcas, A.; Or, M.; Van Goethem, B.; Polis, I.; de Rooster, H.] Univ Ghent, Fac Diergeneeskunde, Vakgrp Geneeskunde & Klin Biol Kleine Huisdieren, Salisburylaan 133, B-9820 Merelbeke, Belgium.
C3 Ghent University
RP de Rooster, H (通讯作者)，Univ Ghent, Fac Diergeneeskunde, Vakgrp Geneeskunde & Klin Biol Kleine Huisdieren, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM hilde.derooster@ugent.be
RI de Rooster, Hilde/AAX-9497-2020; Van Goethem, Bart/AAM-7175-2020
OI de Rooster, Hilde/0000-0001-8087-256X; 
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NR 43
TC 1
Z9 1
U1 0
U2 12
PU UNIV GHENT
PI GHENT
PA FACULTY VETERINARY MEDICINE, B-9000 GHENT, BELGIUM
SN 0303-9021
J9 VLAAMS DIERGEN TIJDS
JI Vlaams Diergeneeskd. Tijdschr.
PD JUL-AUG
PY 2016
VL 85
IS 4
BP 206
EP 214
DI 10.21825/vdt.v85i4.16330
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA DV0HE
UT WOS:000382597800004
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Luo, XB
   Zhou, X
   Wang, Q
   Cai, XJ
   Luo, ZP
   Ma, YZ
AF Luo, Xiao-Bo
   Zhou, Xia
   Wang, Qi
   Cai, Xiao-Jun
   Luo, Zhan-Peng
   Ma, Yuan-Zheng
TI The classification of recurrent spinal epidural hematoma: a review of
   the literature and a comparison with the cases
SO EUROPEAN SPINE JOURNAL
LA English
DT Review
DE Recurrent; Spinal epidural hematoma; Classification; Spontaneous;
   Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; MANAGEMENT
AB Symptomatic postoperative spinal epidural hematoma (SEH) and spontaneous spinal epidural hematoma (SSEH) are both rare conditions, and recurrent SEH occurs even less frequently. Therefore, we describe a case of symptomatic postoperative SEH after surgical evacuation of SSEH, which was diagnosed using magnetic resonance imaging (MRI) and managed with negative pressure wound therapy (NPWT). The authors classified the reported recurrent SEHs into two types based on the cause of their previous hematoma, which can be classified as spontaneous or postoperative. The characteristics, diagnosis, managements, and results of recurrent SEHs were analyzed. The authors suggest that the postoperative SEH in the Type II will be treated with NPWT, and the new classification will be helpful for prognosis, diagnosis, and management of the recurrent SEHs.
C1 [Luo, Xiao-Bo; Wang, Qi; Cai, Xiao-Jun; Luo, Zhan-Peng; Ma, Yuan-Zheng] 309th Hosp Chinese Peoples Liberat Army, Orthoped Ctr, Beijing 100091, Peoples R China.
   [Zhou, Xia] 302th Hosp Chinese Peoples Liberat Army, Dept Transplantat, Beijing, Peoples R China.
RP Ma, YZ (通讯作者)，309th Hosp Chinese Peoples Liberat Army, Orthoped Ctr, Beijing 100091, Peoples R China.
EM abcdefgh_309@163.com
RI Luo, Zhanpeng/PBV-8144-2025
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NR 30
TC 7
Z9 9
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0940-6719
EI 1432-0932
J9 EUR SPINE J
JI Eur. Spine J.
PD MAY
PY 2016
VL 25
SU 1
BP S224
EP S229
DI 10.1007/s00586-016-4506-4
PG 6
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA DV1SK
UT WOS:000382701100040
PM 27002614
DA 2026-07-24
ER
PT J
AU Omar, M
   Gathen, M
   Liodakis, E
   Suero, EM
   Krettek, C
   Zeckey, C
   Petri, M
AF Omar, M.
   Gathen, M.
   Liodakis, E.
   Suero, E. M.
   Krettek, C.
   Zeckey, C.
   Petri, M.
TI A comparative study of negative pressure wound therapy with and without
   instillation of saline on wound healing
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE instillation; negative pressure wound therapy; NPWT; NPWTi; wound
   healing
ID VACUUM-ASSISTED CLOSURE; POLYHEXANIDE; IRRIGATION; MANAGEMENT; SYSTEM;
   ULCERS; SOFT
AB Objective: Negative pressure wound therapy (NPWT) has become an established treatment of traumatic and infected wounds. Negative pressure wound therapy with instillation (NPWTi) is a further development that combines the conventional NPWT with instillation of different fluids which continuously administer therapeutic reagents to the wound. The aim of this study was to compare the impact of additional saline instillation in NPWTi to NPWT alone.
   Method: Between January and July 2014, consecutive patients with acute wounds of the lower limb were treated with NPWTi with saline instillation. The number of revision surgeries, length of hospital stay, and duration of treatment until final healing were recorded and compared with matched patients undergoing NPWT without instillation.
   Results: There were 10 patients recruited with 10 matched controls examined restrospectivley. Patients who received NPWTi were found to have decreased time of hospitalisation (21.5 versus 26.5 days, p = 0.43), and accelerated wound healing (9.0 versus 12.5 days, p = 0.36) than patients who received NPWT. However, the difference in the outcomes of the patients who received NPWTi and patients who received NPWT was not found to be statisticallly significant.
   Conclusion: NPWTi with instillation of saline is a promising method and its effectiveness needs to be tested in a randomised controlled trial compared with NPWT alone.
C1 [Omar, M.; Gathen, M.; Liodakis, E.; Suero, E. M.; Krettek, C.; Zeckey, C.; Petri, M.] Hannover Med Sch, Trauma Dept, Hannover, Germany.
C3 Hannover Medical School
RP Omar, M (通讯作者)，Hannover Med Sch, Trauma Dept, Hannover, Germany.
EM omar.mohamed@mh-hannover.de
RI Liodakis, Emmanouil/Q-1089-2015; Suero, Eduardo/S-9264-2019
OI Liodakis, Emmanouil/0000-0001-8870-6216; Suero,
   Eduardo/0000-0002-7578-8440
FU KCI (Wiebsaden, Germany)
FX This study obtained support by KCI (Wiebsaden, Germany) for the surgical
   material.
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NR 28
TC 29
Z9 35
U1 0
U2 9
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2016
VL 25
IS 8
BP 475
EP 478
DI 10.12968/jowc.2016.25.8.475
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DV7OI
UT WOS:000383125600009
PM 27523660
DA 2026-07-24
ER
PT J
AU Maurya, S
   Bhandari, PS
AF Maurya, Sanjay
   Bhandari, Prem Singh
TI Negative Pressure Wound Therapy in the Management of Combat Wounds: A
   Critical Review
SO ADVANCES IN WOUND CARE
LA English
DT Review
DE combat wounds; negative pressure wound therapy; wound debridement;
   delayed wound closure; soft tissue reconstruction
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; WAR WOUNDS;
   EXPERIENCE; DEVICE; TRIAL; PROLIFERATION; DEBRIDEMENT; FOUNDATION;
   MECHANISM
AB Significance: Wounds sustained in a combat trauma often result in a composite tissue loss. Combat injuries, due to high energy transfer to tissues, lead to trauma at multiple anatomical sites. An early wound cover is associated with lower rate of infections and a faster wound healing. The concept of negative pressure wound therapy (NPWT) in the management of combat-related wounds has evolved from the civilian trauma and the wounds from nontraumatic etiologies. Recent Advances: Encouraged by the results of NPWT in noncombat-related wounds, the military surgeons during Operation Iraqi Freedom and Operation Enduring Freedom used this novel method in a large percentage of combat wounds, with gratifying results. The mechanism of NPWT in wound healing is multifactorial and often complex reconstructive procedure can be avoided in a combat trauma setting. Critical Issues: Wounds sustained in military trauma are heavily contaminated with dirt, patient clothing, and frequently associated with extensive soft tissue loss and osseous destruction. Delay in evacuation during an ongoing conflict carries the risk of systemic infection. Early debridement is indicated followed by delayed closure of wounds. NPWT helps to provide temporary wound cover during the interim period of debridement and wound closure. Future Directions: Future area of research in combat wounds is related to abdominal trauma with loss of abdominal wall. The concept of negative pressure incisional management system in patients with a high risk of wound breakdown following surgery is under review, and may be of relevance in combat wounds.
C1 [Maurya, Sanjay; Bhandari, Prem Singh] Command Hosp, Dept Plast & Reconstruct Surg, Udhampur 182101, India.
RP Maurya, S (通讯作者)，Command Hosp, Dept Plast & Reconstruct Surg, Udhampur 182101, India.
EM drsanjaymaurya@hotmail.com
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NR 51
TC 21
Z9 27
U1 3
U2 22
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD SEP
PY 2016
VL 5
IS 9
BP 379
EP 389
DI 10.1089/wound.2014.0624
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DV9RS
UT WOS:000383279600001
PM 27679749
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Miller, AJ
   Cashmore, RG
   Marchevsky, AM
   Havlicek, M
   Brown, PM
   Fearnside, SM
AF Miller, A. J.
   Cashmore, R. G.
   Marchevsky, A. M.
   Havlicek, M.
   Brown, P. M.
   Fearnside, S. M.
TI Negative pressure wound therapy using a portable single-use device for
   free skin grafts on the distal extremity in seven dogs
SO AUSTRALIAN VETERINARY JOURNAL
LA English
DT Article
DE dogs; negative pressure wound therapy; reconstructive surgery; skin
   graft; soft tissue sarcoma; wound healing
ID VACUUM-ASSISTED CLOSURE; CONTROLLED-TRIAL; THICKNESS; EXPERIENCE; LIMBS
AB ObjectiveRetrospective study to describe clinical experience with a portable single-use negative pressure wound therapy device after application of full-thickness meshed skin grafts to wounds on the distal extremities of seven dogs.
   MethodsSeven dogs were treated with portable NPWT after receiving skin grafts; six as the result of tumour resection and one for traumatic injury. Medical records were reviewed and data recorded on patient signalment, cause and location of wound, surgical technique, application and maintenance of portable NPWT, graft survival and outcome, and complications encountered with the system.
   Clinical outcomes NPWT was provided for between 4 and 7 days. Five patients were discharged from hospital during the treatment period. Application and maintenance of the portable device was technically easy and no major complications were encountered. Minor complications consisted of fluid accumulation in the evacuation tubing. All dogs achieved 100% graft survival.
   ConclusionsApplication and maintenance of the portable device was technically straightforward. All dogs receiving portable NPWT after transfer of a free skin graft to the distal extremity had a successful outcome.
C1 [Miller, A. J.; Cashmore, R. G.; Marchevsky, A. M.; Havlicek, M.; Brown, P. M.; Fearnside, S. M.] Small Anim Specialist Hosp, Level 1,1 Richardson Pl, Sydney, NSW 2113, Australia.
RP Miller, AJ (通讯作者)，Small Anim Specialist Hosp, Level 1,1 Richardson Pl, Sydney, NSW 2113, Australia.
EM amiller@sashvets.com
RI Marchevsky, Andrew/KCK-0833-2024
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NR 30
TC 12
Z9 14
U1 0
U2 21
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0005-0423
EI 1751-0813
J9 AUST VET J
JI Aust. Vet. J.
PD SEP
PY 2016
VL 94
IS 9
BP 309
EP 316
DI 10.1111/avj.12474
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA DW1YL
UT WOS:000383439800017
PM 27569833
DA 2026-07-24
ER
PT J
AU Hwang, KT
   Kim, SW
   Sung, IH
   Kim, JT
   Kim, YH
AF Hwang, Kyu Tae
   Kim, Sang Wha
   Sung, Il Hoon
   Kim, Jeong Tae
   Kim, Youn Hwan
TI Is delayed reconstruction using the latissimus dorsi free flap a worthy
   option in the management of open IIIB tibial fractures?
SO MICROSURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; FASCIOCUTANEOUS FLAPS;
   PERFORATOR FLAP; COVERAGE; TISSUE; EXTREMITIES; MUSCLE; UNION;
   COMPLICATIONS
AB Early reconstruction of severe open fractures, performed within 7 days of the injury, has a better outcome than closure after 7 days. However, the uncertain demarcation of damaged tissue often results in delayed reconstruction. In this article, we report our surgical outcomes of delayed reconstruction using latissimus dorsi free flap with internal fixation. Twenty-three patients with Gustilo type IIIB open tibial fractures Between March 2009 and May 2012 were included in this study. There were 16 cases of distal 1/3 fracture of the tibia, 4 of midshaft fracture, 1 of proximal 1/3 fracture, and 2 of segmental fracture. Serial debridement with application of negative pressure wound therapy (NPWT) was performed before the final operation. All patients underwent internal fixation of the bone and reconstruction of soft tissue defect using latissimus dorsi free flap. The number of serial debridements, excluding those performed during emergency and finial operation, ranged from 1 to 5 (mean 2.69) times. Mean time from injury to final operation was 10.65 (range, 7-22) days. All flaps survived without complications. Three cases (13%) were infected, and three cases required further bone graft surgery to facilitate bone union (13%). Bone union was achieved after a mean 6.3 (range, 3-12) months. Mean follow-up period was 16.34 (range, 12-26) months. During follow-up, all patients were able to ambulate without use of an aid. In cases of severe open fracture, treatment should emphasize soft tissue coverage rather than rushing to achieve definitive fixation in the setting of poor surrounding tissues. When delayed reconstruction is inevitable, radical debridement is performed first, then NPWT is used as bridging therapy, and free flap could be considered for definite soft tissues coverage. (c) 2015 Wiley Periodicals, Inc. Microsurgery 36:453-459, 2016.
C1 [Hwang, Kyu Tae; Sung, Il Hoon] Hanyang Univ, Dept Orthoped Surg, Coll Med, Seoul, South Korea.
   [Kim, Sang Wha] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Plast & Reconstruct Surg, Coll Med, Seoul, South Korea.
   [Kim, Jeong Tae; Kim, Youn Hwan] Hanyang Univ, Dept Plast & Reconstruct Surg, Coll Med, Seoul, South Korea.
C3 Hanyang University; Seoul National University (SNU); Seoul National
   University Hospital; Hanyang University
RP Kim, YH (通讯作者)，Hanyang Univ, Sch Med, Dept Plast & Reconstruct Surg, 17 Haengdang Dong, Seoul 133792, South Korea.
EM younhwank@daum.net
RI Hwang, Kyu/R-7249-2016
OI Kim, Sang Wha/0000-0003-0430-3458
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   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
   Wen G, 2013, MICROSURG, V33, P625, DOI 10.1002/micr.22162
   Wood T, 2012, J TRAUMA ACUTE CARE, V72, P1078, DOI 10.1097/TA.0b013e31823fb06b
   Yazar S, 2006, PLAST RECONSTR SURG, V117, P2468, DOI 10.1097/01.prs.0000224304.56885.c2
   Zhou M, 2013, MICROSURG, V33, P620, DOI 10.1002/micr.22178
   Zhu YL, 2013, MICROSURG, V33, P600, DOI 10.1002/micr.22177
NR 37
TC 16
Z9 23
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD SEP
PY 2016
VL 36
IS 6
BP 453
EP 459
DI 10.1002/micr.22428
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DW4FT
UT WOS:000383598700002
PM 25976771
DA 2026-07-24
ER
PT J
AU Qiu, SS
   Hsu, CC
   Hanna, SA
   Chen, SHY
   Cheong, CF
   Lin, CH
   Chang, TNJ
AF Qiu, Shan Shan
   Hsu, Chung-Chen
   Hanna, Steven Alexander
   Chen, Sirena Hsin-Yu
   Cheong, Chon-Fok
   Lin, Chih-Hung
   Chang, Tommy Nai-Jen
TI Negative pressure wound therapy for the management of flaps with venous
   congestion
SO MICROSURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SALVAGE; REPLANTATION
AB PurposeThe aim of this report is to evaluate the utility of negative pressure wound therapy (NPWT) for rescuing flaps with venous congestion not attributable to a mechanical etiology and that cannot be surgically salvaged.
   Patients and methodsA total of 12 patients suffered from partial or total flap congestion after pedicle or free-flap reconstruction was included. All patients underwent NPWT between 3 and 10 days postoperatively.
   ResultsAll congested flaps survived after the application of NPWT. Nine patients suffered partial flap loss and this was addressed through debridement of the devitalized tissue and primary closure. Three patients required blood transfusions during the course of their management. All patients presented complete coverage of the defects without further problems in the flaps after the treatment.
   ConclusionNPWT may be considered an alternative management strategy for flaps, which has undergone venous congestion not due to a mechanical cause. (c) 2016 Wiley Periodicals, Inc. Microsurgery 36:467-473, 2016.
C1 [Qiu, Shan Shan; Hsu, Chung-Chen; Chen, Sirena Hsin-Yu; Cheong, Chon-Fok; Lin, Chih-Hung; Chang, Tommy Nai-Jen] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, 5 Fu Hsing St, Taoyuan, Taiwan.
   [Qiu, Shan Shan; Hsu, Chung-Chen; Chen, Sirena Hsin-Yu; Cheong, Chon-Fok; Lin, Chih-Hung; Chang, Tommy Nai-Jen] Chang Gung Univ, Sch Med, Taoyuan, Taiwan.
   [Qiu, Shan Shan] Maastrich Univ, Med Ctr, Dept Plast Surg, Maastricht, Netherlands.
   [Hanna, Steven Alexander] Queens Univ, Sch Med, Kingston, ON, Canada.
C3 Chang Gung Memorial Hospital; Chang Gung University; Maastricht
   University; Queens University - Canada
RP Chang, TNJ (通讯作者)，Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, 5 Fu Hsing St, Taoyuan, Taiwan.
EM tommynjchanag@yahoo.com.tw
RI ; Hanna, Steven/AAM-8130-2021
OI qiu, shan shan/0000-0002-0616-9566; Hanna, Steven/0000-0002-7286-1868
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NR 28
TC 25
Z9 32
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD SEP
PY 2016
VL 36
IS 6
BP 467
EP 473
DI 10.1002/micr.30027
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DW4FT
UT WOS:000383598700004
PM 26806399
DA 2026-07-24
ER
PT J
AU Kirsner, RS
   Romanelli, M
AF Kirsner, Robert S.
   Romanelli, Marco
TI Use of advanced technologies across the wound care spectrum: prologue
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chronic wounds; Epidermal skin grafts; Negative pressure wound therapy;
   Wound healing
ID VENOUS LEG ULCERS; FOOT ULCERS; BURDEN
AB The growing trends of ageing populations and increasing prevalence of diabetes have given rise to an expanding number of problematic acute and chronic wounds. Over the past two decades, the use of negative pressure wound therapy (NPWT) with and without instillation of topical wound solutions has expanded to include treatment of a large variety of wounds. Additionally, the use of NPWT specifically designed for use over closed surgical incisions has been associated with favourable results. The recent introduction of an automated epidermal harvesting system, which neither creates a donor site wound nor requires the use of a surgeon, operating room or anaesthesia, has facilitated the use of epidermal grafting. This supplement highlights some of the advanced wound approaches that have been developed to address challenging wounds and the growing burden of wound care affecting both the patient and the health care system.
C1 [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, 1600 NW 10th Ave Rosenstiel Med Sci Bldg, Miami, FL 33136 USA.
   [Romanelli, Marco] Univ Pisa, Dept Dermatol, Wound Healing Res Unit, Pisa, Italy.
C3 University of Miami; University of Pisa
RP Kirsner, RS (通讯作者)，Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, 1600 NW 10th Ave Rosenstiel Med Sci Bldg, Miami, FL 33136 USA.
EM Rkirsner@miami.edu
RI romanelli, marco/ABI-1154-2020
OI romanelli, marco/0000-0002-4127-0141
FU ACELITY
FX Drs. Kirsner and Romanelli served as consultants to KCI, an ACELITY
   Company, and presented as faculty members at an ACELITY symposium held
   in conjunction with the 2016 World Union of Wound Healing Societies
   (WUWHS) conference. This article is part of an ACELITY-funded supplement
   based on the 2016 WUWHS ACELITY symposium presentations. ACELITY
   provided editorial assistance.
CR Alavi A, 2016, J AM ACAD DERMATOL, V74, P644, DOI 10.1016/j.jaad.2015.03.059
   Armstrong David G, 2007, Int Wound J, V4, P286
   Eaglstein WH, 2012, WOUND REPAIR REGEN, V20, P793, DOI 10.1111/j.1524-475X.2012.00849.x
   Lyder C.H., 2008, Patient safety and quality: An evidence-based handbook for nurses, p1
   Martins-Mendes D, 2014, J DIABETES COMPLICAT, V28, P632, DOI 10.1016/j.jdiacomp.2014.04.011
   Nole KLB, 2015, JAMA DERMATOL, V151, P583, DOI 10.1001/jamadermatol.2014.5112
   Redelings Matthew D, 2005, Adv Skin Wound Care, V18, P367, DOI 10.1097/00129334-200509000-00010
   Rice J Bradford, 2014, J Med Econ, V17, P347, DOI 10.3111/13696998.2014.903258
   Rice JB, 2014, DIABETES CARE, V37, P651, DOI 10.2337/dc13-2176
   Sen CK, 2009, WOUND REPAIR REGEN, V17, P763, DOI 10.1111/j.1524-475X.2009.00543.x
   Singh N, 2005, JAMA-J AM MED ASSOC, V293, P217, DOI 10.1001/jama.293.2.217
NR 11
TC 2
Z9 3
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP
PY 2016
VL 13
SU 3
SI SI
BP 5
EP 7
DI 10.1111/iwj.12633
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DW4HL
UT WOS:000383603700001
PM 27547957
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Teng, SC
AF Teng, Shou-Cheng
TI Use of negative pressure wound therapy in burn patients
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Burns; Negative pressure wound therapy; Skin grafts; Wound healing
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; BOLSTER; DEVICE; TRIAL
AB According to previous research, adjunctive negative pressure wound therapy (NPWT) can help manage infected wounds when applied along with appropriate debridement and antibiotic therapy as deemed clinically relevant. NPWT not only removes fluid, and reduces oedema, but also promotes perfusion around the wounds. In addition, NPWT may lead to improved graft fixation when used as a bolster, especially in patients who are less compliant or have poor graft fixation that result from using traditional methods. NPWT is a good choice to bolster skin grafts in young, active and less-compliant patients. We propose an enhanced segmental compartment-covered technique, which uses NPWT adjunctively as first-line wound treatment to help manage postoperative infection. Moreover, NPWT promotes granulation tissue formation to prepare the wound bed for subsequent skin graft and may be used as a bolster over the graft, which helps to attain skin graft viability.
C1 [Teng, Shou-Cheng] Triserv Gen Hosp, Dept Plast & Reconstruct Surg, 325,Sect 2 Chenggong Rd, Taipei 114, Taiwan.
C3 Tri-Service General Hospital
RP Teng, SC (通讯作者)，Triserv Gen Hosp, Dept Plast & Reconstruct Surg, 325,Sect 2 Chenggong Rd, Taipei 114, Taiwan.
EM dscjmh@gmail.com
FU ACELITY
FX Dr Teng served as a consultant to KCI, an ACELITY Company, and presented
   as a faculty member at an ACELITY symposium parallel to the 2016 World
   Union of Wound Healing Societies (WUWHS) conference. This article is a
   part of an ACELITY-funded supplement based on the 2016 WUWHS ACELITY
   symposium presentations. ACELITY provided editorial assistance.
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NR 14
TC 14
Z9 22
U1 1
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP
PY 2016
VL 13
SU 3
SI SI
BP 15
EP 18
DI 10.1111/iwj.12641
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DW4HL
UT WOS:000383603700003
PM 27547959
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Anghel, EL
   Kim, PJ
   Attinger, CE
AF Anghel, Ersilia L.
   Kim, Paul J.
   Attinger, Christopher E.
TI A solution for complex wounds: the evidence for negative pressure wound
   therapy with instillation
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Debridement; Instillation; Limb salvage; Negative pressure wound
   therapy; Review; Wound healing
ID VACUUM-ASSISTED CLOSURE; ANTISEPTIC SOLUTION; MULTICENTER; IRRIGATION;
   SALINE
AB Negative pressure wound therapy with instillation and dwell time (NPWTi-d) is an adjunctive therapy that can be used in the management of complex wounds with infection. NPWTi-d incorporates the intermittent instillation of a topical solution to the wound in a programmed manner. Unlike standard negative pressure wound therapy, NPWTi-d delivers topical wound solutions directly to the wound, allows the solution to dwell over the wound bed, and removes the solution during the negative pressure phase. The authors review the evidence for using NPWTi-d and the role it may potentially play in helping to reduce hospital stay, number of debridement operations and cost.
C1 [Anghel, Ersilia L.; Kim, Paul J.; Attinger, Christopher E.] MedStar Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
C3 Georgetown University
RP Attinger, CE (通讯作者)，Georgetown Univ Hosp, Dept Plast Surg, 3800 Reservoir Rd 1 Bles, Washington, DC 20007 USA.
EM cattinger@aol.com
OI , Paul/0000-0002-6186-6890
FU ACELITY; KCI; ACELITY Company; Integra LifeSciences Corp.
FX Dr. Attinger presented as a faculty member at an ACELITY symposium
   parallel to the 2016 World Union of Wound Healing Societies (WUWHS)
   conference. This article is part of an ACELITY-funded supplement based
   on the 2016 WUWHS Acelity symposium presentations. ACELITY provided
   editorial assistance.Ersilia Anghel has no financial disclosures,
   commercial associations or any other conditions posing a conflict of
   interest to report. Dr. Kim has received consulting and research funding
   from KCI, an ACELITY Company, and Integra LifeSciences Corp. Dr.
   Attinger is a consultant for KCI, an ACELITY Company, Smith & Nephew
   Inc. and Integra Life Sciences Corp.
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NR 26
TC 26
Z9 33
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP
PY 2016
VL 13
SU 3
SI SI
BP 19
EP 24
DI 10.1111/iwj.12664
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DW4HL
UT WOS:000383603700004
PM 27547960
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Willy, C
   Engelhardt, M
   Stichling, M
   Grauhan, O
AF Willy, Christian
   Engelhardt, Michael
   Stichling, Marcus
   Grauhan, Onnen
TI The impact of surgical site occurrences and the role of closed incision
   negative pressure therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Closed incision negative pressure wound therapy; Negative pressure wound
   therapy; Surgical incision management; Surgical site infection
ID STERNAL WOUND-INFECTION; INTERNAL THORACIC ARTERY; LONG-TERM SURVIVAL;
   VACUUM-ASSISTED CLOSURE; RISK-FACTORS; DIABETIC-PATIENTS;
   CARDIAC-SURGERY; STERNOTOMY INFECTION; OBESE-PATIENTS; PREVENTION
AB Surgical site occurrences are observed in up to 60% of inpatient surgical procedures in industrialised countries. The most relevant postoperative complication is surgical site infection (SSI) because of its impact on patient outcomes and enormous treatment costs. Literature reviews (SSI', deep sternal wound infections' (DSWI), closed incision negative pressure wound therapy' (ciNPT) were performed by electronically searching MEDLINE (PubMed) and subsequently using a snowball' method of continued searches of the references in the identified publications. Search criteria included publications in all languages, various study types and publication in a peer-reviewed journal. The SSI literature search identified 1325, the DSWI search 590 and the ciNPT search 103 publications that fulfilled the search criteria. Patient-related SSI risk factors (diabetes mellitus, obesity, smoking, hypertension, female gender) and operation-related SSI risk factors (re-exploration, emergency operations, prolonged ventilation, prolonged operation duration) exist. We found that patient- and operation-related SSI risk factors were often different for each speciality and/or operative procedure. Based on the evidence, we found that high-risk incisions (sternotomy and incisions in extremities after high-energy open trauma) are principally recommended for ciNPT use. In lower'-risk incisions, the addition of patient-related or operation-related risk factors justifies the application of ciNPT.
C1 [Willy, Christian] Bundeswehr Hosp Berlin, Dept Traumatol Orthoped Surg Sept & Reconstruct S, Res & Treatment Ctr Complex Combat Injuries, Berlin, Germany.
   [Engelhardt, Michael] Bundeswehr Hosp Ulm, Dept Vasc & Endovasc Surg, Ctr Vasc Med, Ulm, Germany.
   [Stichling, Marcus] Bundeswehr Hosp Berlin, Dept Traumatol Orthoped Surg Sept & Reconstruct S, Res & Treatment Ctr Complex Combat Injuries, Sect Vasc & Thorac Surg, Berlin, Germany.
   [Grauhan, Onnen] German Heart Ctr Berlin, Cardiac Surg, Berlin, Germany.
C3 Ulm University; Military Hospital Ulm; German Heart Center Berlin
RP Willy, C (通讯作者)，Bundeswehr Hosp Berlin, Dept Traumatol Orthoped Surg Sept & Reconstruct S, Surg, Colonel, Scharnhorststr 13, D-10115 Berlin, Germany.; Willy, C (通讯作者)，Bundeswehr Hosp Berlin, Dept Traumatol Orthoped Surg Sept & Reconstruct S, Dept, Scharnhorststr 13, D-10115 Berlin, Germany.; Willy, C (通讯作者)，Bundeswehr Hosp Berlin, Res & Treatment Ctr Complex Combat Injuries, Wound Ctr, Bundeswehr Hosp Berlin ICW, Scharnhorststr 13, D-10115 Berlin, Germany.
EM christianwilly@bundeswehr.org
FU ACELITY
FX Dr. Willy served as a consultant to KCI, an ACELITY Company, and
   presented as a faculty member at an ACELITY symposium parallel to the
   2016 World Union of Wound Healing Societies (WUWHS) conference. Dr.
   Grauhan is a consultant to KCI, an ACELITY Company. This article is part
   of a ACELITY-funded supplement based on the 2016 WUWHS ACELITY symposium
   presentations. ACELITY provided editorial assistance.
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NR 67
TC 14
Z9 16
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP
PY 2016
VL 13
SU 3
SI SI
BP 35
EP 46
DI 10.1111/iwj.12659
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DW4HL
UT WOS:000383603700006
PM 27547962
OA Green Accepted
DA 2026-07-24
ER
PT J
AU Misky, A
   Hotouras, A
   Ribas, Y
   Ramar, S
   Bhan, C
AF Misky, A.
   Hotouras, A.
   Ribas, Y.
   Ramar, S.
   Bhan, C.
TI A systematic literature review on the use of vacuum assisted closure for
   enterocutaneous fistula
SO COLORECTAL DISEASE
LA English
DT Review
DE Enterocutaneous fistula; vacuum assisted closure; negative pressure
   therapy
ID GASTROINTESTINAL FISTULAS; OPEN ABDOMEN; MANAGEMENT; MORTALITY
AB AimEnterocutaneous fistula (ECF) is considered to be one of the most challenging complications a general surgeon can encounter. The current mainstay of treatment is surgical closure, associated with significant morbidity and mortality. Vacuum assisted closure (VAC) has been successfully used for closure of persistent abdominal wounds for a number of years. This study aims to investigate whether current literature supports the use of VAC for ECF.
   MethodA PubMed search of the search terms enterocutaneous fistula' and vacuum assisted closure/therapy' was performed in December 2014. Results were restricted to articles involving human subjects with an available abstract and full text written between 1950 and 2014. The end-points analysed included rate of fistula closure, duration of follow-up, and morbidity and mortality where available.
   ResultsTen studies (all level IV) including 151 patients were examined. In all except one, surgery was the underlying aetiology with median number of fistulae per patient of one. The median rate of closure with VAC was 64.6% (7.7-100%) with healing occurring within 58 (12-90)days. Follow-up was only mentioned in three of the 10 studies, in which the patients were followed for 3, 20 and 28.5months. No complications were reported in all but one of the studies, in which abdominal wall disruption and intestinal obstruction were identified in a minority of patients.
   ConclusionThe included studies suggest that VAC therapy may be considered a safe treatment for ECF. The current evidence is generally of low level and characterized by heterogeneity. Definitive recommendations based on this information cannot therefore be made. Further studies are necessary to establish any proven benefit over standard surgical or conservative therapy.
C1 [Misky, A.] UCL, Sch Med, London, England.
   [Hotouras, A.] Univ Coll London Hosp, North East London Deanery, London, England.
   [Ribas, Y.] Consorci Sanitari Terrassa, Dept Surg, Barcelona, Spain.
   [Ramar, S.] Kings Coll Hosp London, London, England.
   [Bhan, C.] UCL, Dept Colorectal Surg, Whittington Hlth NHS Trust, London, England.
C3 University of London; University College London; UCL Medical School;
   University College London Hospitals NHS Foundation Trust; University of
   London; University College London; King's College Hospital NHS
   Foundation Trust; King's College Hospital; University of London;
   University College London
RP Hotouras, A (通讯作者)，Barts & London Queen Marys Sch Med & Dent, Natl Ctr Bowel Res & Surg Innovat, Barts Hlth NHS Trust, Acad Surg Unit, 1st Floor,Abernethy Bldg,2 Newark St, London E1 2AT, England.
EM alex007@doctors.org.uk
RI RIBAS, YOLANDA/AAG-1532-2020
OI RIBAS, YOLANDA/0000-0002-9254-2864; Misky, Adam/0000-0002-5679-6293
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NR 29
TC 21
Z9 31
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD SEP
PY 2016
VL 18
IS 9
BP 846
EP 851
DI 10.1111/codi.13351
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA DW4QP
UT WOS:000383628400009
PM 27088556
DA 2026-07-24
ER
PT J
AU Elizondo, RA
   Au, JK
   Gargollo, PC
   Tu, DT
AF Elizondo, Rodolfo A.
   Au, Jason K.
   Gargollo, Patricio C.
   Tu, Duong T.
TI Vacuum-assisted Closure of a Vesicocutaneous Fistula in a Pediatric
   Patient After Bladder Cystoplasty
SO UROLOGY
LA English
DT Article
ID PRESSURE WOUND THERAPY; MANAGEMENT; REPAIR
AB A vesicocutaneous fistula is an abnormal communication from the bladder to the skin (Pritts et al, 2001). Recently, wound vacuum-assisted closure (VAC) has been used to facilitate fistula closure. There are no reports of using VAC to help fistula closure in the pediatric population. We present a case of an adolescent patient who develops a vesicocutaneous fistula after bladder augment cystoplasty and was treated with VAC only. (C) 2016 Elsevier Inc.
C1 [Elizondo, Rodolfo A.] Texas Childrens Hosp, Dept Pediat Urol, 6701 Fannin St 620-01, Houston, TX 77030 USA.
   Mayo Clin, Dept Pediat Urol, Rochester, MI USA.
C3 Baylor College of Medicine; Baylor College Medical Hospital; Mayo Clinic
RP Elizondo, RA (通讯作者)，Texas Childrens Hosp, Dept Pediat Urol, 6701 Fannin St 620-01, Houston, TX 77030 USA.
EM raelizon@texaschildrens.org
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NR 15
TC 5
Z9 5
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD SEP
PY 2016
VL 95
BP 190
EP 191
DI 10.1016/j.urology.2016.04.001
PG 2
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DW5PK
UT WOS:000383698300046
PM 27058688
DA 2026-07-24
ER
PT J
AU Nolff, MC
   Pieper, K
   Meyer-Lindenberg, A
AF Nolff, Mirja C.
   Pieper, Korbinian
   Meyer-Lindenberg, Andrea
TI Treatment of a perforating thoracic bite wound in a dog with negative
   pressure wound therapy
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SEPTIC PERITONITIS; CATS; SKIN; MANAGEMENT;
   RECONSTRUCTION; GRAFTS; MESH
AB CASE DESCRIPTION
   A 4-year-old male Dachshund was examined following a bite attack that had occurred 5 days previously. The dog had acutely deteriorated despite IV antimicrobial treatment and fluid therapy.
   CLINICAL FINDINGS
   On initial examination, the patient was recumbent with signs of septic shock and a flail chest. Three penetrating wounds in the left thoracic wall with malodorous discharge were evident. The animal trauma triage score was 8 out of 18. Thoracic and abdominal radiography revealed displaced fractures of the left seventh, eighth, and ninth ribs and extensive subcutaneous emphysema. Additionally, a marked diffuse bronchointerstitial pattern, areas of alveolar pattern, and pneumothorax were present bilaterally.
   TREATMENT AND OUTCOME
   Open surgical debridement with left lateral lung lobectomy and resection of portions of the left thoracic wall were performed. Extensive soft tissue loss precluded primary reconstruction. The defect was stabilized with a polypropylene mesh implant, and negative pressure wound therapy (NPWT) at -100 mm Hg was initiated. Microbial culture and susceptibility testing of tissue samples indicated the presence of multidrug-resistant Staphylococcus pseudintermedius. The NPWT dressing was changed 2, 5, and 7 days after surgery. Treatment was well tolerated, and the mesh was completely covered with granulation tissue 10 days after surgery. On follow-up 5, 7, 12, and 19 months after surgery, the dog was clinically normal with no apparent complications.
   CLINICAL RELEVANCE
   Findings suggested that NPWT may be a valuable adjunct when treating small animal patients with severe thoracic trauma.
C1 [Nolff, Mirja C.; Pieper, Korbinian; Meyer-Lindenberg, Andrea] Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Germany.
C3 University of Munich
RP Nolff, MC (通讯作者)，Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Germany.
EM m.nolff@lmu.de
RI Nolff, Mirja/W-6756-2019; Pieper, Korbinian/HRA-0638-2023;
   Meyer-Lindenberg, Andreas/H-1076-2011
OI Nolff, Mirja/0000-0001-9317-7769; 
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NR 36
TC 6
Z9 7
U1 0
U2 23
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
EI 1943-569X
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD OCT 1
PY 2016
VL 249
IS 7
BP 794
EP 800
DI 10.2460/javma.249.7.794
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA DW5RY
UT WOS:000383705800028
PM 27654166
DA 2026-07-24
ER
PT J
AU Morisaki, A
   Hosono, M
   Murakami, T
   Sakaguchi, M
   Suehiro, Y
   Nishimura, S
   Sakon, Y
   Yasumizu, D
   Kawase, T
   Shibata, T
AF Morisaki, Akimasa
   Hosono, Mitsuharu
   Murakami, Takashi
   Sakaguchi, Masanori
   Suehiro, Yasuo
   Nishimura, Shinsuke
   Sakon, Yoshito
   Yasumizu, Daisuke
   Kawase, Takumi
   Shibata, Toshihiko
TI Effect of negative pressure wound therapy followed by tissue flaps for
   deep sternal wound infection after cardiovascular surgery: propensity
   score matching analysis
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Deep sternal wound infection; MRSA; Negative pressure wound therapy;
   Tissue flaps
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; POSTSTERNOTOMY
   MEDIASTINITIS; RISK-FACTORS; MUSCLE FLAP; COMPLICATIONS
AB OBJECTIVES: Deep sternal wound infection (DSWI) after cardiovascular surgery via median sternotomy remains a severe complication associated with a drastic decrease in the quality of life. We assessed the risk factors for in- hospital death caused by DSWI and the available treatments for DSWI.
   METHODS: Between January 1991 and August 2015, we retrospectively reviewed 73 patients (51 males and 22 females, mean age 67.5 +/- 10.3 years) who developed DSWI after cardiovascular surgery via median sternotomy. Pathogenic bacteria mainly comprised methicillin- resistant Staphylococcus aureus (MRSA) (49.3%). Fifteen patients (20.5%) died in hospital with DSWI. Treatment of DSWI consisted of open daily irrigation (up to 2006) or negative pressure wound therapy (NPWT) (2007 onwards), followed by primary closure or reconstruction of tissue flaps. We assessed the risk factors for in- hospital mortality from DSWI by comparing data from the 15 patients who died and the 58 survivors using propensity score matching analysis of the treatments used for DSWI.
   RESULTS: Univariate analysis identified age, use of intra-aortic balloon pumping, prolonged mechanical ventilation, tracheotomy, prolonged intensive care unit stay, postoperative low output syndrome, postoperative myocardial infarction, postoperative renal failure, postoperative use of haemodialysis, postoperative pneumonia, postoperative cerebral disorder, MRSA infection, NPWT and tissue flaps as being associated with in- hospital mortality (P < 0.05). Multivariate analysis identified NPWT (odds ratio, 0.062; 95% confidence interval, 0.004-0.897; P = 0.041) and tissue flaps (odds ratio, 0.022; 95% confidence interval, 0.000-0.960; P = 0.048) as independently associated with reduced in- hospital mortality after DSWI. On comparing 22 patients receiving NPWT with 22 not on NPWT using propensity score matching, patients on NPWT had significantly lower in- hospital mortality than those without NPWT (NPWT vs non-NPWT, 5 vs 36%, P = 0.021). In DSWI infected by MRSA, NPWT significantly reduced the in- hospital mortality caused by DSWI (NPWT vs non-NPWT, 0 vs 52%, P = 0.003).
   CONCLUSIONS: NPWT and tissue flaps may be favourable factors associated with reduced in- hospital mortality attributable to DSWI. NPWT as a bridge therapy to tissue flaps may play a major role in treating DSWI and improve the prognosis for patients withMRSA-infected DSWI.
C1 [Morisaki, Akimasa; Hosono, Mitsuharu; Murakami, Takashi; Sakaguchi, Masanori; Suehiro, Yasuo; Nishimura, Shinsuke; Sakon, Yoshito; Yasumizu, Daisuke; Kawase, Takumi; Shibata, Toshihiko] Osaka City Univ, Grad Sch Med, Dept Cardiovasc Surg, Osaka, Japan.
C3 Osaka Metropolitan University
RP Morisaki, A (通讯作者)，Osaka City Univ, Grad Sch Med, Dept Cardiovasc Surg, Abeno Ku, 1-4-3 Asahimachi, Osaka 5458585, Japan.
EM m3_514@yahoo.co.jp
RI MORISAKI, AKIMASA/ADI-0738-2022; Shibata, Toshihiko/ISB-3776-2023
CR ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
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NR 24
TC 36
Z9 45
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD SEP
PY 2016
VL 23
IS 3
BP 397
EP 402
DI 10.1093/icvts/ivw141
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA DW8JX
UT WOS:000383902600009
PM 27199380
OA Bronze
DA 2026-07-24
ER
PT J
AU Cirocchi, R
   Birindelli, A
   Biffl, WL
   Mutafchiyski, V
   Popivanov, G
   Chiara, O
   Tugnoli, G
   Di Saverio, S
AF Cirocchi, Roberto
   Birindelli, Arianna
   Biffl, Walter L.
   Mutafchiyski, Ventsislav
   Popivanov, Georgi
   Chiara, Osvaldo
   Tugnoli, Gregorio
   Di Saverio, Salomone
TI What is the effectiveness of the negative pressure wound therapy (NPWT)
   in patients treated with open abdomen technique? A systematic review and
   meta-analysis
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Review
DE Open abdomen; negative pressure wound therapy (NPWT); damage control
   laparostomy; abdominal sepsis and compartment syndrome; systematic
   review
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM-ASSISTED CLOSURE; MEDIATED FASCIAL
   TRACTION; MANAGEMENT; FISTULA; LAPAROSTOMY; TRAUMA; DEVICE
AB BACKGROUND The open abdomen technique may be used in critically ill patients to manage abdominal injury, reduce the septic complications, and prevent the abdominal compartment syndrome. Many different techniques have been proposed and multiple studies have been conducted, but the best method of temporary abdominal closure has not been determined yet. Recently, new randomized and nonrandomized controlled trials have been published on this topic. We aimed to perform an up-to-date systematic review on the management of open abdomen, including the most recent published randomized and nonrandomized controlled trials, to compare negative pressure wound therapy (NPWT) with no NPWT and define if one technique has better outcomes than the other with regard to primary fascial closure, postoperative 30-day mortality and morbidity, enteroatmospheric fistulae, abdominal abscess, bleeding, and length of stay.
   METHODS According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and the Cochrane Handbook for Systematic Reviews of Interventions, an online literature research (until July 1, 2015) was performed on MEDLINE, PubMed, Cochrane Central Register of Controlled Trials, and Cochrane Library databases. The MeSH terms and free words used vacuum assisted closure vac;, open abdomen, damage control surgery, and temporary abdominal closure. No language restriction was made.
   RESULTS The initial systematic literature search yielded 452 studies. After a careful assessment of the titles and of the full text was obtained, eight articles fulfilled inclusion criteria. We analyzed 1,225 patients, of whom 723 (59%) underwent NPWT and 502 (41%) did not undergo NPWT, and performed four subgroups: VAC versus Bogota bag technique (two studies, 106 participants), VAC versus mesh-foil laparostomy (two studies, 159 participants), VAC versus laparostomy (adhesive impermeable with midline zip) (one study, 106 participants), and NPWT versus no NPWT techniques (three studies, 854 participants) in which it is not possible to perform an analysis of the different types of treatment. Comparing the NPWT group and the group without NPWT, there was no statistically significant difference in fascial closure (63.5% vs 69.5%; odds ratio [OR], 0.74; 95% confidence interval [CI], 0.27-2.06; p = 0.57), postoperative 30-day overall morbidity (p = 0.19), postoperative enteroatmospheric fistulae rate (2.1% vs 5.8%; OR, 0.63; 95% CIs, 0.12-3.15; p = 0.57), in the postoperative bleeding rate (5.7% vs 14.9%; OR, 0.58; 95% CIs, 0.05-6.84; p = 0.87), and postoperative abdominal abscess rate (2.4% vs 5.6%; OR, 0.42; 95% CI, 0.13-1.34; p = 0.14). On the other hand, statistical significance was found between the NPWT group and the group without NPWT in the postoperative mortality rate (28.5% vs 41.4%; OR, 0.46; 95% CI, 0.23-0.91; p = 0.03) and in the length of stay in the intensive care unit (mean difference, -4.53; 95% CI, -5.46 to 3.60; p < 0.00001).
   CONCLUSION The limitations of the present analysis might be related to the lack of randomized controlled trials, so there is a risk of selection bias favoring NPWT. For several outcomes, there were few studies, confidence intervals were wide, and inconsistency was high, suggesting that although there were no statistically significant differences between the groups, there was insufficient evidence to show that the outcomes were similar. We can conclude from the current available data that NPWT seems to be associated with a trend toward better outcomes compared to the use of no NPWT. It does reflect the evidence presented in the current systematic review; however, the data should be interpreted with substantial caution given a number of weaknesses (in particular, the lack of statistical significance and heterogeneity between studies, i.e., small sample size of the included studies, high variability between studies). We highlight the need for randomized controlled trials having homogeneous inclusion criteria to assess the use of NPWT for the management of open abdomen.
   LEVEL OF EVIDENCE Systemic review/meta-analysis, level III.
C1 [Cirocchi, Roberto] Univ Perugia, Dept Gen & Oncol Surg, Terni, Italy.
   [Birindelli, Arianna] Univ Bologna, Gen Surg, Bologna, Italy.
   [Biffl, Walter L.] Univ Hawaii, Queens Med Ctr, Acute Care Surg, Honolulu, HI 96822 USA.
   [Mutafchiyski, Ventsislav] Mil Med Acad, Dept Surg, Sofia, Bulgaria.
   [Popivanov, Georgi] Mil Med Acad, Clin Endoscop Endocrine Surg & Coloproctol, Sofia, Bulgaria.
   [Chiara, Osvaldo] Niguarda Hosp Trauma Ctr, Milan, Italy.
   [Tugnoli, Gregorio; Di Saverio, Salomone] Maggiore Hosp, Reg Emergency Surg & Trauma Ctr, Bologna Local Hlth Dist, Trauma Surg Unit, Bologna, Italy.
C3 University of Perugia; University of Bologna; The Queen's Medical
   Center; University of Hawaii System; Military Medical Academy Sofia;
   Military Medical Academy Sofia; AUSL di Bologna
RP Di Saverio, S (通讯作者)，Maggiore Hosp, Ctr Trauma, Emergency Surg & Trauma Surg Unit, Bologna, Italy.
EM salo75@inwind.it
RI Di Saverio, Salomone/G-1437-2012; Cirocchi, Roberto/I-1197-2014
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   [Anonymous], MANAGEMENT OPEN ABDO
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NR 59
TC 70
Z9 87
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD SEP
PY 2016
VL 81
IS 3
BP 575
EP 584
DI 10.1097/TA.0000000000001126
PG 10
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA DW8MX
UT WOS:000383911200023
PM 27257705
DA 2026-07-24
ER
PT J
AU Harris, BN
   Bewley, AF
AF Harris, Brianna N.
   Bewley, Arnaud F.
TI Minimizing free flap donor-site morbidity
SO CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
LA English
DT Review
DE anterolateral thigh; donor-site morbidity; fibula flap; free flap;
   radial forearm
ID ANTEROLATERAL THIGH FLAP; FOREARM FREE-FLAP; THICKNESS-SKIN-GRAFT;
   HARVEST; RECONSTRUCTION; COMPLICATIONS; MANAGEMENT; FULL; ARM
AB Purpose of reviewFasciocutaneous and osteocutaneous free flap reconstruction has significantly changed the way surgeons reconstruct defects following ablation of head and neck tumors. Over time, success rates of free flaps have approached 98%, allowing surgeons to shift their focus to minimizing morbidities associated with the donor sites. The radial forearm, anterolateral thigh, and fibula free flaps are the three most commonly used flaps in head and neck reconstruction, and therefore each of their advantages and associated morbidities are of particular interest. The present article aims to review the morbidities associated with each of the commonly used head and neck free flaps and techniques to minimize them that are described in the most recent literature.Recent findingsNew techniques such as negative-pressure wound therapy, full thickness grafts, and rotational flaps have been developed recently that minimize these morbidities.SummaryThe techniques described in the current review may improve long-term patient outcomes both esthetically and functionally.
C1 [Harris, Brianna N.; Bewley, Arnaud F.] Univ Calif Davis, Davis Dept Otolaryngol Head & Neck Surg, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis
RP Bewley, AF (通讯作者)，Univ Calif Davis, Davis Dept Otolaryngol Head & Neck Surg, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95817 USA.
EM abewley@ucdavis.edu
OI Harris, Brianna/0000-0001-6229-9907
CR Agostini T, 2013, J CRANIO MAXILL SURG, V41, P15, DOI 10.1016/j.jcms.2012.05.003
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NR 32
TC 44
Z9 47
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1068-9508
EI 1531-6998
J9 CURR OPIN OTOLARYNGO
JI Curr. Opin. Otolaryngol. Head Neck Surg.
PD OCT
PY 2016
VL 24
IS 5
BP 447
EP 452
DI 10.1097/MOO.0000000000000286
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA DW8PH
UT WOS:000383917500013
PM 27455033
DA 2026-07-24
ER
PT J
AU Park, CH
   Shon, OJ
   Kim, GB
AF Park, Chul Hyun
   Shon, Oog Jin
   Kim, Gi Beom
TI Negative pressure wound therapy for Gustilo Anderson grade IIIb open
   tibial fractures
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Gustilo Anderson grade IIIb open fractures; negative pressure wound
   therapy; staged protocol; tibia
ID SUBATMOSPHERIC PRESSURE; STAGED PROTOCOL; MANAGEMENT; FIXATION; SHAFT;
   FLAP; RECONSTRUCTION; TRAUMA
AB Background: Traditionally, Gustilo Anderson grade IIIb open tibial fractures have been treated by initial wide wound debridement, stabilization of fracture with external fixation, and delayed wound closure. The purpose of this study is to evaluate the clinical and radiological results of staged treatment using negative pressure wound therapy (NPWT) for Gustilo Anderson grade IIIb open tibial fractures.
   Materials and Methods: 15 patients with Gustilo Anderson grade IIIb open tibial fractures, treated using staged protocol by a single surgeon between January 2007 and December 2011 were reviewed in this retrospective study. The clinical results were assessed using a Puno scoring system for severe open fractures of the tibia at the last followup. The range of motion (ROM) of the knee and ankle joints and postoperative complication were evaluated at the last followup. The radiographic results were assessed using time to bone union, coronal and sagittal angulations and a shortening at the last followup.
   Results: The mean score of Puno scoring system was 87.4 (range 67-94). The mean ROM of the knee and ankle joints was 121.3 degrees (range 90 degrees-130 degrees) and 37.7 degrees (range 15 degrees-50 degrees), respectively. Bone union developed in all patients and the mean time to union was 25.3 weeks (range 16-42 weeks). The mean coronal angulation was 2.1 degrees (range 0-4 degrees) and sagittal was 2.7 degrees (range 1-4 degrees). The mean shortening was 4.1 mm (range 0-8 mm). Three patients had partial flap necrosis and 1 patient had total flap necrosis. There was no superficial and deep wound infection.
   Conclusion: Staged treatment using NPWT decreased the risks of infection and requirement of flap surgeries in Gustilo Anderson grade IIIb open tibial fractures. Therefore, staged treatment using NPWT could be a useful treatment option for Gustilo Anderson grade IIIb open tibial fractures.
C1 [Park, Chul Hyun; Shon, Oog Jin; Kim, Gi Beom] Yeungnam Univ Hosp, Dept Orthoped Surg, Daemyung Dong 317-1, Daegu 705717, South Korea.
C3 Yeungnam University; Yeungnam University Hospital
RP Shon, OJ (通讯作者)，Yeungnam Univ Hosp, Dept Orthoped Surg, Daemyung Dong 317-1, Daegu 705717, South Korea.
EM ossoj@med.yu.ac.kr
RI Kim, Gi Beom/AAG-6315-2020; Park, Chul Hyun/ABE-4464-2020
OI Kim, Gi Beom/0000-0002-4067-1285; Park, Chul Hyun/0000-0002-3101-8655
FU Yeungnam University Medical Center
FX This research was supported by a grant of Yeungnam University Medical
   Center (2014).
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NR 26
TC 10
Z9 15
U1 0
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD SEP-OCT
PY 2016
VL 50
IS 5
BP 536
EP 542
DI 10.4103/0019-5413.189604
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA DW9NM
UT WOS:000383987100014
PM 27746498
OA hybrid
DA 2026-07-24
ER
PT J
AU Shi, JZ
   Zhai, X
   Li, JH
   Xue, CY
   Bi, HD
AF Shi Jia-zi
   Zhai Xiao
   Li Jun-hui
   Xue Chun-yu
   Bi Hong-da
TI Negative pressure wound therapy combined with skin grafting improves
   surgical wound healing in the perianal area
SO MEDICINE
LA English
DT Article
DE negative pressure wound therapy; perianal tumor; perianal wound; skin
   grafting
ID OF-THE-LITERATURE; PAGETS-DISEASE; EXCISION; DEFECTS; RECONSTRUCTION;
   MANAGEMENT; REPAIR; FLAPS
AB Management of large tissue defects resulting from local wide resection of perianal is a clinical challenge for surgeons. The aim of the present study was to investigate the efficacy of negative pressure wound therapy (NPWT) following skin grafting on perianal surgical wound healing.Included in this study were 12 patients with perianal tumors who received skin grafting after perianal tumor resection between December 2012 and December 2014. A self-designed negative pressure drainage device was then applied to maintain a standard negative pressure at -150mm Hg and removed on day 8 postoperation. The outcome was recorded immediately after NPWT and at 6-month follow-up.All skin grafts survived without infection, hematoma, and necrosis in all 12 patients. No tumor recurrence was detected during 6-month follow-up. Natural folds were observed around the anus. All patients showed normal bowel movements.NPWT following skin grafting was effective for perianal surgical wound healing and infection prevention, thus benefiting anatomical and functional recovery of the anus.
C1 [Shi Jia-zi; Zhai Xiao] Second Mil Med Univ, Grad Management Unit, Shanghai, Peoples R China.
   [Li Jun-hui; Xue Chun-yu; Bi Hong-da] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Li, JH; Xue, CY; Bi, HD (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM lissot@163.com; xcyfun@sina.com; bihongda0411@163.com
CR Conklin A, 2009, J GASTROINTEST SURG, V13, P951, DOI 10.1007/s11605-009-0822-x
   Delaunoit T, 2004, ACTA GASTRO-ENT BELG, V67, P228
   Fujii M, 2007, J PLAST RECONSTR AES, V60, P1208, DOI 10.1016/j.bjps.2007.02.005
   Gupta S, 2012, INT WOUND J, V9, P40, DOI 10.1111/j.1742-481X.2012.01019.x
   Hassan I, 2001, AM J SURG, V181, P363, DOI 10.1016/S0002-9610(01)00578-5
   Kishi K, 2010, J PLAST RECONSTR AES, V63, P1353, DOI 10.1016/j.bjps.2009.06.022
   Kyriazanos ID, 2011, SURG ONCOL, V20, pE61, DOI 10.1016/j.suronc.2010.09.005
   Lam DTY, 2001, DIS COLON RECTUM, V44, P868, DOI 10.1007/BF02234711
   Mermerkaya U, 2016, INT WOUND J, V13, P394, DOI 10.1111/iwj.12318
   Minicozzi A, 2010, INT J COLORECTAL DIS, V25, P1, DOI 10.1007/s00384-009-0797-9
   Möller MG, 2014, AM J SURG, V207, P485, DOI 10.1016/j.amjsurg.2013.04.005
   St Peter SD, 2004, AM J SURG, V187, P413, DOI 10.1016/j.amjsurg.2003.12.021
NR 12
TC 7
Z9 10
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG
PY 2016
VL 95
IS 35
AR e4670
DI 10.1097/MD.0000000000004670
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DX0HC
UT WOS:000384041400050
PM 27583890
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU De Vries, FEE
   Wallert, ED
   Solomkin, JS
   Allegranzi, B
   Egger, M
   Dellinger, EP
   Boermeester, MA
AF De Vries, Fleur E. E.
   Wallert, Elon D.
   Solomkin, Joseph S.
   Allegranzi, Benedetta
   Egger, Matthias
   Dellinger, E. Patchen
   Boermeester, Marja A.
TI A systematic review and meta-analysis including GRADE qualification of
   the risk of surgical site infections after prophylactic negative
   pressure wound therapy compared with conventional dressings in clean and
   contaminated surgery
SO MEDICINE
LA English
DT Review
DE incisional wound therapy; prevention; prophylactic negative pressure
   wound therapy; surgical site infection; wound infections
ID CESAREAN-SECTION; PREVENTION; INCISIONS; COST; COMPLICATIONS;
   MANAGEMENT; VACUUM
AB Objective:Systematically review and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) studies on prophylactic negative pressure wound therapy (pNPWT) to prevent surgical site infections (SSIs).Introduction:pNPWT has been suggested as a new method to prevent wound complications, specifically SSIs, by its application on closed incisional wounds.Methods:This review was conducted as part of the development of the Global Guidelines for prevention of SSIs commissioned by World Health Organization in Geneva. PubMed, Embase, CENTRAL, CINAHL, and the World Health Organization database between January 1, 1990 and October 7, 2015 were searched. Inclusion criteria were randomized controlled trials and observational studies comparing pNPWT with conventional wound dressings and reporting on the incidence of SSI. Meta-analyses were performed with a random effect model. GRADE Pro software was used to qualify the evidence.Results:Nineteen articles describing 21 studies (6 randomized controlled trials and 15 observational) were included in the review. Summary estimate showed a significant benefit of pNPWT over conventional wound dressings in reducing SSIs in both randomized controlled trials and observational studies, odds ratio of 0.56 (95% confidence interval, 0.32-0.96; P = 0.04) and odds ratio of 0.30 (95% confidence interval, 0.22-0.42; P<0.00001), respectively. This translates into lowering the SSI rate from 140 to 83 (49-135) per 1000 patients and from 106 to 34 (25-47) per 1000 patients, respectively. In stratified analyses, these results were consistent in both clean and clean-contaminated procedures and in different types of surgery, however results were no longer significant for orthopaedic/trauma surgery. The level of evidence as qualified with GRADE was however low.Conclusions:Low-quality evidence indicates that prophylactic NPWT significantly reduces the risk of SSIs.
C1 [De Vries, Fleur E. E.; Wallert, Elon D.; Boermeester, Marja A.] Acad Med Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands.
   [Solomkin, Joseph S.] Univ Cincinnati, Coll Med, Dept Surg, Cincinnati, OH USA.
   [Allegranzi, Benedetta] WHO, Serv Delivery & Safety, Infect Prevent & Control Global Unit, Geneva, Switzerland.
   [Egger, Matthias] Univ Bern, Inst Social & Prevent Med, CH-3012 Bern, Switzerland.
   [Dellinger, E. Patchen] Univ Washington, Dept Surg, Seattle, WA 98195 USA.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   System of Ohio; University of Cincinnati; World Health Organization;
   University of Bern; University of Washington; University of Washington
   Seattle
RP De Vries, FEE (通讯作者)，Acad Med Ctr, POB 22660, NL-1100 DD Amsterdam, Netherlands.
EM f.e.devries@amc.uva.nl
RI ; Dellinger, E./AFZ-2144-2022; Wallert, Elon/HQZ-0375-2023
OI Egger, Matthias/0000-0001-7462-5132; Solomkin,
   Joseph/0000-0001-6382-4902; Boermeester, Marja/0000-0003-3890-8105; 
FU Merck; Ortho-McNeil; Targanta; Schering-Plough; Astellas; Allergan; Care
   Fusion; Durata; Pfizer; Applied Medical; Rib-X; Affinium; Tetraphase;
   Televancin; R-Pharm; Cubist; Melinta; 3M; Motif; JJ/Ethicon; Acelity;
   Ipsen; Baxter; Mylan
FX EPD reports personal fees from Merck, Ortho-McNeil, Targanta,
   Schering-Plough, Astellas, Allergan, Care Fusion, Durata, Pfizer,
   Applied Medical, Rib-X, Affinium, Tetraphase, Televancin, R-Pharm,
   Cubist, Melinta, 3M and grants from Motif, outside the submitted work.
   MAB reports institutional grants from J&J/Ethicon, Acelity, Ipsen,
   Baxter, Mylan, outside the submitted work; advisory board member of
   J&J/Ethicon and Acelity.
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NR 45
TC 75
Z9 84
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP
PY 2016
VL 95
IS 36
AR e4673
DI 10.1097/MD.0000000000004673
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DX4JE
UT WOS:000384346200031
PM 27603360
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Cheong, JY
   Goltsman, D
   Warrier, S
AF Cheong, Ju Yong
   Goltsman, David
   Warrier, Sanjay
TI A New Method of Salvaging Breast Reconstruction After Breast Implant
   Using Negative Pressure Wound Therapy and Instillation
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Breast; Wound breakdown; Implant failure; Reconstruction; Nipple-sparing
   mastectomy; Negative pressure wound therapy (NPWT); Automated volumetric
   fluid administration
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   WOUNDS; MULTICENTER; INFECTIONS; INSTILL(R); FOAM
AB Breast implant infections and their associated inflammatory response can have severe consequences, such as the loss of the prosthesis and cavity, or extensive scarring. Negative pressure wound therapy has been indicated for the management of implant infections. This report describes situations where negative pressure wound therapy was used in conjunction with instillation therapy to treat breast implant infections. The findings showed that the application of these techniques accelerated the treatment of the infections and, most importantly, maintained the breast cavity for future reconstruction.
   This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
C1 [Cheong, Ju Yong; Goltsman, David; Warrier, Sanjay] Royal Prince Alfred Hosp, Div Breast Surg, 119-143 Missenden Rd, Sydney, NSW 2050, Australia.
   [Cheong, Ju Yong; Goltsman, David; Warrier, Sanjay] Chris OBrien Lifehouse, 119-143 Missenden Rd, Sydney, NSW 2050, Australia.
C3 NSW Health; Royal Prince Alfred Hospital; University of Sydney; Chris
   O'Brien Lifehouse
RP Cheong, JY (通讯作者)，Royal Prince Alfred Hosp, Div Breast Surg, 119-143 Missenden Rd, Sydney, NSW 2050, Australia.; Cheong, JY (通讯作者)，Chris OBrien Lifehouse, 119-143 Missenden Rd, Sydney, NSW 2050, Australia.
EM santiago-james@hotmail.com
OI Warrier, Sanjay/0009-0000-6863-1296
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Bernstein BH, 2005, WOUNDS, V17, P37
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Giacalone PL, 2006, BREAST J, V12, P481, DOI 10.1111/j.1075-122X.2006.00306.x
   Köster G, 2009, INFECTION, V37, P18
   Leak K, 2009, WOUNDS UK, V5, P47
   Lehner B, 2009, INFECTION, V37, P13
   Lehner B, 2011, INT ORTHOP, V35, P1415, DOI 10.1007/s00264-011-1274-y
   Luedders DW, 2011, ARCH GYNECOL OBSTET, V283, P1357, DOI 10.1007/s00404-010-1594-y
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   Timmers MS, 2009, WOUND REPAIR REGEN, V17, P278, DOI 10.1111/j.1524-475X.2009.00458.x
   Wolvos Tom, 2004, Ostomy Wound Manage, V50, P56
NR 15
TC 20
Z9 23
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD OCT
PY 2016
VL 40
IS 5
BP 745
EP 748
DI 10.1007/s00266-016-0668-z
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DX5QX
UT WOS:000384437600015
PM 27422257
DA 2026-07-24
ER
PT J
AU Cagnoni, G
   Rimoldi, SG
   Pagani, C
   Savi, C
   Stefani, F
   Terzi, R
   Olivieri, P
   Tosi, G
   Parravicini, C
   Di Gregorio, A
   Antona, C
   Gismondo, MR
AF Cagnoni, Giovanni
   Rimoldi, Sara Giordana
   Pagani, Cristina
   Savi, Claudio
   Stefani, Fabrizio
   Terzi, Roberta
   Olivieri, Pietro
   Tosi, Giulia
   Parravicini, Carlo
   Di Gregorio, Annamaria
   Antona, Carlo
   Gismondo, Maria Rita
TI Can Drainage Using a Negative-Pressure Wound Therapy Device Replace
   Traditional Sample Collection Methods?
SO SURGICAL INFECTIONS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; POSTSTERNOTOMY MEDIASTINITIS;
   RISK-FACTORS; INFECTION; MANAGEMENT; POPULATION; IMPACT
AB Background: In 2015 a new device for the collection of mediastinal fluid from patients with deep sternal wound infection (DSWI) in the presence of negative-pressure wound therapy (NPWT) became available. The present study was designed to evaluate whether changing sample collection devices increased micro-organism detection in patients undergoing NPWT.
   Methods: During 2013-2014, 207 samples were collected and cultured from NPWT patients (n = 23) to demonstrate the presence of DSWI using reticulated polyurethane sponge culture, a swab, and blood culture. In 2015, a new collection device was introduced for specimen collection. A total of 357 samples (n = 17) were collected using the ESwab(TM) (Copan, Murrieta, CA) for deep and superficial wound sample collection. In addition, blood culture devices were used for collecting mediastinal fluid aspirated directly from the wound and biologic fluid obtained from the NPWT device. Fisher exact test was performed to test the rate of independence rate of micro-organism identification using the NPWT sponge device and taking blood culture results as a reference for micro-organism identification.
   Results: After the introduction of the new collection device in our hospital, an overall increase in the detection of micro-organisms (46.7%) was reported. During 2013-2014 our traditional microbiologic collection method did not detect a pathogen in 30.4% of patients. During 2015, the new sample collection approach, direct from the NPWT device, improved micro-organism detection by 10.4% and reduced DSWIs with undetected pathogens to 17.6% (p < 0.01).
   Conclusions: As a result of proficiency gained in the last year, the most representative specimen in wound infection was represented by mediastinal fluid collected directly from the wound and the NPWT device. Given the correlation between the blood culture of micro-organisms detected using the ESwab device from the wound, mediastinal drainage, and drainage from the NPWT device, we can assume that the NPWT device may replace the other biologic sampling devices.
C1 [Cagnoni, Giovanni; Antona, Carlo] Azienda Osped Polo Univ Luigi Sacco, Unita Operat Cardiochirurg, Milan, Italy.
   [Rimoldi, Sara Giordana; Pagani, Cristina; Di Gregorio, Annamaria; Gismondo, Maria Rita] Azienda Osped Polo Univ Luigi Sacco, Lab Microbiol Clin Virol & Diagnost Bioemergenze, Via GB Grassi 74, I-20157 Milan, Italy.
   [Savi, Claudio] Azienda Osped Polo Univ Luigi Sacco, Unita Operat Cardioanestesia, Milan, Italy.
   [Terzi, Roberta] Azienda Osped Polo Univ Luigi Sacco, Div Malattie Infett, Milan, Italy.
   [Olivieri, Pietro] Azienda Osped Polo Univ Luigi Sacco, Direz Med Presidio, Milan, Italy.
   [Tosi, Giulia] Azienda Osped Polo Univ Luigi Sacco, Unita Operat Farm, Milan, Italy.
   [Parravicini, Carlo] Azienda Osped Polo Univ Luigi Sacco, Div Anat Patol, Milan, Italy.
   [Stefani, Fabrizio] Ist Ric Acque IRSA CNR, Brugherio, Italy.
C3 University of Milan; Luigi Sacco Hospital; University of Milan; Luigi
   Sacco Hospital; University of Milan; Luigi Sacco Hospital; University of
   Milan; Luigi Sacco Hospital; University of Milan; Luigi Sacco Hospital;
   University of Milan; Luigi Sacco Hospital; University of Milan; Luigi
   Sacco Hospital; Consiglio Nazionale delle Ricerche (CNR); Istituto di
   Ricerca sulle Acque (IRSA-CNR)
RP Rimoldi, SG (通讯作者)，Azienda Osped Polo Univ Luigi Sacco, Lab Microbiol Clin Virol & Diagnost Bioemergenze, Via GB Grassi 74, I-20157 Milan, Italy.
EM rimoldi.sara@hsacco.it
RI STEFANI, FABRIZIO/C-8752-2011; ANTONA, CARLO/F-1760-2017; Gismondo,
   Maria Rita/I-3965-2017
OI STEFANI, FABRIZIO/0000-0001-5200-0529; ANTONA,
   CARLO/0000-0002-9003-0240; Gismondo, Maria Rita/0000-0001-6926-8660
CR Ariyaratnam P, 2010, INTERACT CARDIOV TH, V11, P543, DOI 10.1510/icvts.2010.237883
   Baillot R, 2010, EUR J CARDIO-THORAC, V37, P880, DOI 10.1016/j.ejcts.2009.09.023
   Bitkover CY, 2000, ANN THORAC SURG, V69, P1110, DOI 10.1016/S0003-4975(99)01432-0
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   Steingrimsson S, 2008, SCAND CARDIOVASC J, V42, P208, DOI 10.1080/14017430801919557
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NR 21
TC 3
Z9 6
U1 1
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD OCT
PY 2016
VL 17
IS 5
BP 577
EP 582
DI 10.1089/sur.2016.026
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA DX6BM
UT WOS:000384467200013
PM 27348793
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Jaehn, T
   Sievers, R
   Junger, A
   Graunke, F
   Blings, A
   Reichert, B
AF Jaehn, T.
   Sievers, R.
   Junger, A.
   Graunke, F.
   Blings, A.
   Reichert, B.
TI Fatal hyperpyrexia in an adolescent patient with severe burns after a
   traffic accident
SO UNFALLCHIRURG
LA German
DT Article
DE Burns; Dermis replacement; Hyperpyrexia; Negative pressure wound
   therapy; Propofol infusion syndrome
ID HYPERTHERMIA
AB After a motorcycle accident a 16-year-old patient suffered severe burns to 40.5 % of the total body surface area (TBSA) of which 37 % were deep subdermal burns. After tangential and partly epifascial necrosectomy, Integra. was used as a temporary dermis replacement material for the lower extremities, combined with extensive negative pressure wound therapy (NPWT). In the further course of the treatment the patient developed uncontrollable hyperpyrexia with a fatal outcome. Possible influencing factors, such as the dermis replacement material combined with NPWT over large areas as well as the differential diagnoses propofol infusion syndrome, heatstroke and malignant hyperthermia are discussed.
C1 [Jaehn, T.; Sievers, R.; Graunke, F.; Reichert, B.] Paracelsus Med Privatuniv, Klinikum Nurnberg, Zentrum Schwerbrandverletzte, Univ Klin Plast Wiederherstellende & Handchirurg, Nurnberg, Germany.
   [Junger, A.; Blings, A.] Paracelsus Med Privatuniv, Klinikum Nurnberg, Univ Klin Anasthesiol & Operat Intens Med, Nurnberg, Germany.
C3 Klinikum Nurnberg; Klinikum Nurnberg
RP Jaehn, T (通讯作者)，Paracelsus Med Privatuniv, Klinikum Nurnberg, Zentrum Schwerbrandverletzte, Univ Klin Plast Wiederherstellende & Handchirurg, Nurnberg, Germany.
EM tobias.jaehn@klinikum-nuernberg.de
CR Adam H, 2007, ANASTH INTENSIVMED, V10, P692
   Bouchama A, 2002, NEW ENGL J MED, V346, P1978, DOI 10.1056/NEJMra011089
   BROCHHAUSEN C, 2008, INTENSIVMED NOTFALLM, V45, P31, DOI DOI 10.1007/s00390-007-0836-0
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   Wappler F, 2001, EUR J ANAESTH, V18, P632, DOI 10.1046/j.1365-2346.2001.00888.x
NR 10
TC 0
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD JUL
PY 2016
VL 119
IS 7
BP 609
EP 612
DI 10.1007/s00113-015-0132-6
PG 4
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA DX9TZ
UT WOS:000384739900010
PM 26767381
DA 2026-07-24
ER
PT J
AU Geiger, SE
   Deigni, OA
   Watson, JT
   Kraemer, BA
AF Geiger, Scott E.
   Deigni, Olivier A.
   Watson, John Tracy
   Kraemer, Bruce A.
TI Management of Open Distal Lower Extremity Wounds With Exposed Tendons
   Using Porcine Urinary Bladder Matrix
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE lower extremity wounds; surgical wounds; porcine urinary bladder
   extracellular matrix; tissue repair
ID SOFT-TISSUE DEFECTS; NEGATIVE-PRESSURE THERAPY; ACHILLES-TENDON;
   EXTRACELLULAR-MATRIX; RECONSTRUCTION; TRANSFERS; COVERAGE; INTEGRA; FLAP
AB Open wounds of the distal third of the leg and foot with an exposed tendon present a challenge in wound management and in attaining stable, durable coverage. The mobility of the tendon often leads to chronic inflammation that impedes wound closure, while the desiccation of the exposed tendon leads to progressive tendon necrosis. For the authors' cases, the ability of extracellular matrix (ECM) products to modulate wound bed inflammation and facilitate constructive remodeling of a wound seemed a reasonable approach in treating these wounds, especially in patients who are often poor surgical candidates for more advanced reconstructive procedures. Methods. The authors reviewed 13 patients who had open wounds of the distal third of the leg and/or foot that had associated tendon involvement in the wound (Achilles, 6; tibialis anterior, 6; and peroneal, 1). Patients' wounds were treated to total closure. The clinical course and patient management is reviewed herein. Results. The authors found newer ECM products can provide a More optimal method of management of patients with exposed tendons, as compared to prolonged negative pressure wound therapy. Conclusion. Furthermore, the authors conclude the use of newer ECM products yields a more stable, less scarred, reconstructed wound that more closely resembles normal foot and: ankle appearance compared to other more complex reconstructive operative procedures.
C1 [Geiger, Scott E.; Deigni, Olivier A.; Kraemer, Bruce A.] St Louis Univ, Sch Med, Div Plast & Reconstruct Surg, 3635 Vista Ave,3rd Floor Desloge Towers, St Louis, MO 63110 USA.
   [Watson, John Tracy] St Louis Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA.
C3 Saint Louis University; Saint Louis University
RP Kraemer, BA (通讯作者)，St Louis Univ, Sch Med, Div Plast & Reconstruct Surg, 3635 Vista Ave,3rd Floor Desloge Towers, St Louis, MO 63110 USA.; Kraemer, BA (通讯作者)，St Louis Univ, Sch Med, Div Plast & Reconstruct Surg, Plast Surg, 3635 Vista Ave,3rd Floor Desloge Towers, St Louis, MO 63110 USA.
EM kraemerb@slu.edu
FU ACell Inc
FX Dr. Kraemer participates in the Key Opinion Leaders Bureau for ACell
   Inc, Columbia, MD and has received monies for presenting his clinical
   experience using the porcine urinary bladder matrix-extracellular matrix
   products described in this paper. Dr. Geiger received travel and hotel
   expenses from ACell Inc to present a poster including these clinical
   cases at the Orthopaedic Trauma Association 2014 Annual Meeting in
   Tampa, FL.
CR Attinger CE, 2006, PLAST RECONSTR SURG, V117, P2460, DOI 10.1097/01.prs.0000219345.73727.f5
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NR 25
TC 26
Z9 31
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2016
VL 28
IS 9
BP 306
EP 316
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DY4FQ
UT WOS:000385054800003
PM 27701126
DA 2026-07-24
ER
PT J
AU Wahab, NAA
   Saadeh, FA
   Wong, A
   Gleeson, N
AF Wahab, N. A. A.
   Saadeh, F. A.
   Wong, A.
   Gleeson, N.
TI Negative pressure wound treatment (NPWT) in vulva and groin wounds in
   gynaecologic oncology
SO EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
LA English
DT Article
DE Vulva and groin wounds; Negative pressure wound treatment
ID VACUUM-ASSISTED CLOSURE; VAGINAL RECONSTRUCTION; NEOVAGINAL
   RECONSTRUCTION; CANCER; FLAP; COMPLICATIONS; MANAGEMENT; THERAPY;
   OMENTOPLASTY; EXENTERATION
AB Secondary healing of complicated vulvar and groin wounds is a major challenge due to its moist condition and at risk of contamination by colonic flora. Vacuum assisted closure is the controlled application of sub-atmospheric pressure to the local wound environment using a sealed dressing connected to a vacuum pump. Materials and Methods: The NPWT consists of an open-pore polyurethane ether foam sponge, an adhesive cover, fluid collection system, and suction pump that generates negative pressure. Direct application of sponge to blood vessels, bone, nerves or intact skin is avoided. The dressing and tubing are changed every 48-72 hours. Results: Eight patients had NPWT following the vulva and/or groin surgery. Pain during removal of the sponge was the main adverse event requiring narcotic analgesia. All wounds healed completely. One patient is dead of disease progression. Others are alive without disease at four to 48 months. Conclusion: Wound breakdown in vulvar and groin surgery is an infrequent occurrence because of the rarity of full radical excision for vulva cancer and infralevator pelvic exenterative surgery. The present experience with NPWT was favourable.
C1 [Wahab, N. A. A.; Saadeh, F. A.; Wong, A.; Gleeson, N.] St James Hosp, Dept Gynaecol, Gynaecol Oncol Div, Jamess St St, Dublin 8, Ireland.
C3 Trinity College Dublin
RP Gleeson, N (通讯作者)，St James Hosp, Dept Gynaecol, Gynaecol Oncol Div, Jamess St St, Dublin 8, Ireland.
EM noreengleeson@dubgyn.org
RI Abu Saadeh, Feras/AAM-2119-2021
OI Abu Saadeh, Feras/0000-0002-9598-8650
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NR 32
TC 3
Z9 3
U1 0
U2 4
PU I R O G CANADA, INC
PI MONTREAL
PA 4900 COTE ST-LUC, APT#212, MONTREAL, QUEBEC H3W 2H3, CANADA
SN 0392-2936
J9 EUR J GYNAECOL ONCOL
JI Eur. J. Gynaecol. Oncol.
PY 2016
VL 37
IS 5
BP 632
EP 637
DI 10.12892/ejgo3099.2016
PG 6
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA DY4FX
UT WOS:000385055500007
PM 29787000
DA 2026-07-24
ER
PT J
AU Weckbach, S
   Lutz, B
   Wölfle-Roos, JV
   Reichel, H
AF Weckbach, S.
   Lutz, B.
   Woelfle-Roos, J. V.
   Reichel, H.
TI Infections of the spine. Therapeutic strategies
SO CHIRURG
LA German
DT Article
DE Spondylitis; Spondylodiscitis; Antibiotics; Operative therapy;
   Nonsurgical therapy
ID VERTEBRAL OSTEOMYELITIS; WOUND-INFECTION; MANAGEMENT; SPONDYLODISCITIS;
   FUSION; INSTRUMENTATION; DIAGNOSIS; ADULTS
AB Spinal infections are relatively rare entities but the incidence is significantly increasing due to the rapidly growing numbers of interventions on the spine. Primary infections of intervertebral discs (spondylodiscitis) and vertebral bodies (spondylitis) are distinguished from secondary postinterventional infections. Treatment relies primarily on either conservative or surgical management. In the absence of indications for surgery, a conservative approach is indicated when the patient is neurologically intact and the bony destruction is minimal. Conservative therapeutic options are based on the microbiological diagnosis and use of antibiotics, immobilization, analgesics and orthotics. Indications for a surgical intervention are the presence of neurological deficits, intraspinal abscesses, extensive osseous destruction and failure of conservative management. Surgical therapy focusses on the decompression of neural structures, debridement and eradication of the focus of infection, pathogen identification, correction of the deformity and restoration of a physiological spinal profile. Following a postoperative infection a timely diagnosis including assessment of the extent of infection is crucial. In the case of a purely superficial infection, antibiotic prophylaxis and close monitoring is indicated. If findings are pronounced surgical revision, debridement together with antibiotic therapy and if necessary vacuum-assisted closure as well as revision ranging from exchange of implants to complete removal of osteosynthetic material are required. Spinal infections are severe conditions frequently with residual long-term sequelae, whether the patients are managed conservatively or surgically.
C1 [Weckbach, S.; Lutz, B.; Woelfle-Roos, J. V.; Reichel, H.] Univ Ulm, RKU, Orthopad Univ Klin Ulm, Oberer Eselsberg 45, D-89081 Ulm, Germany.
C3 Ulm University
RP Weckbach, S (通讯作者)，Univ Ulm, RKU, Orthopad Univ Klin Ulm, Oberer Eselsberg 45, D-89081 Ulm, Germany.
EM Sebastian.Weckbach@rku.de
RI Lutz, Bernd/AAS-8025-2021
OI Lutz, Bernd/0000-0003-2599-5836
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NR 20
TC 3
Z9 5
U1 2
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD OCT
PY 2016
VL 87
IS 10
BP 839
EP 846
DI 10.1007/s00104-016-0247-5
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DY5TF
UT WOS:000385165500005
PM 27484826
DA 2026-07-24
ER
PT J
AU Müller, CSL
   Burgard, B
   Zimmerman, M
   Vogt, T
   Pföhler, C
AF Mueller, Cornelia Sigrid Lissi
   Burgard, Barbara
   Zimmerman, Monika
   Vogt, Thomas
   Pfoehler, Claudia
TI On the significance of negative-pressure wound therapy with instillation
   in dermatology
SO JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; CHRONIC LEG ULCERS; INSTILL(R) THERAPY; SALINE
   INSTILLATION; TOPICAL TREATMENT; INFECTED WOUNDS; FIBRIN MATRIX; CASE
   SERIES; IN-VITRO; OSTEOMYELITIS
AB Methods used in the treatment of acute and chronic wounds undergo constant evolution, reevaluation, and innovation. While negative-pressure wound therapy (NPWT) is an established treatment modality, the combination of NPWT and instillation of normal saline as well as solutions with active antiseptic components for topical treatment of the wound bed represents a novel approach. The well-known effects of NPWT may thus be combined with those of local antisepsis. They include a decrease in wound area, induction of granulation tissue, and reduction in bacterial colonization. To date, studies have focused on NPWT with instillation for orthopedic/surgical indications, whereas clinical data in dermatosurgery is limited to case reports or small case series. There are as yet no randomized prospective studies investigating NPWT with instillation in the treatment of skin disorders. The goal of this review is to present the method of NPWT with instillation, to highlight its mode of action as well as possible complications and contraindications, and to review the recent literature. In summary, there is increasing evidence that both simple and complicated wounds may be effectively treated with NPWT with instillation, resulting in markedly accelerated tissue granulation and thus earlier defect closure.
C1 [Mueller, Cornelia Sigrid Lissi; Burgard, Barbara; Zimmerman, Monika; Vogt, Thomas; Pfoehler, Claudia] Univ Hosp Saarland, Dept Dermatol Allergol & Venereol, Kirrberger Str, D-66421 Homburg, Germany.
C3 Universitatsklinikum des Saarlandes
RP Müller, CSL (通讯作者)，Univ Hosp Saarland, Dept Dermatol Allergol & Venereol, Kirrberger Str, D-66421 Homburg, Germany.
EM cornelia.mueller@uks.eu
OI Müller, Cornelia/0000-0002-7656-721X
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NR 66
TC 5
Z9 8
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1610-0379
EI 1610-0387
J9 J DTSCH DERMATOL GES
JI J. Dtsch. Dermatol. Ges.
PD AUG
PY 2016
VL 14
IS 8
BP 786
EP 795
DI 10.1111/ddg.13038
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DY6XI
UT WOS:000385272200003
PM 27509412
OA Bronze
DA 2026-07-24
ER
PT J
AU Özkan, B
   Kapdagli, M
   Duman, S
   Demir, A
   Toker, A
AF Ozkan, Berker
   Kapdagli, Murat
   Duman, Salih
   Demir, Adalet
   Toker, Alper
TI Endobronchial valve and vacuum-assisted closure treatment for a
   complicated air leak problem after cardiac surgery
SO TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND
   CARDIOVASCULAR SURGERY
LA English
DT Article
DE Mediastinal infection; pleural air leak; surgery complications
ID BRONCHOPLEURAL FISTULAS; COILS
AB In this article, we report a 57-year-old male patient who developed mediastinitis due to massive air leak after coronary bypass surgery and deteriorated with endobronchial valve application. The patient underwent a long and complicated treatment process with open drainage and vacuum-assisted closure applications and recovered. Although endobronchial valve applications are efficient in the treatment of prolonged air leak, we recommend considering open drainage and vacuum-assisted closure if infectious complications occur.
C1 [Ozkan, Berker; Kapdagli, Murat; Duman, Salih; Demir, Adalet; Toker, Alper] Istanbul Univ, Istanbul Fac Med, Dept Thorac Surg, Istanbul, Turkey.
C3 Istanbul University
RP Özkan, B (通讯作者)，Istanbul Univ, Istanbul Tip Fak, Gogus Cerrahisi Anabilim Dali, TR-34093 Istanbul, Turkey.
EM berkerozkan@yahoo.com
RI Özkan, Berker/AAE-8781-2020; /AAW-1876-2020; Demir, Adalet/PGF-0550-2026
CR Ferguson JS, 2006, CHEST, V129, P479, DOI 10.1378/chest.129.2.479
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   Watanabe S, 2003, THORAC CARDIOV SURG, V51, P106, DOI 10.1055/s-2003-38981
NR 5
TC 0
Z9 0
U1 0
U2 3
PU BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
PI ATASEHIR
PA ORNEK MH DR SUPHI EZGI SK SARAY APT NO 11 D 6, ATASEHIR, ISTANBUL 34704,
   TURKEY
SN 1301-5680
J9 TURK GOGUS KALP DAMA
JI Turk Gogus Kalp Damar Cerrahisi Derg.
PD JUL
PY 2016
VL 24
IS 3
BP 589
EP 591
DI 10.5606/tgkdc.dergisi.2016.12211
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DY6XJ
UT WOS:000385272300032
OA hybrid
DA 2026-07-24
ER
PT J
AU Skrinjar, E
   Duschek, N
   Bayer, GS
   Assadian, O
   Koulas, S
   Hirsch, K
   Basic, J
   Assadian, A
AF Skrinjar, Edda
   Duschek, Nikolaus
   Bayer, Gottfried S.
   Assadian, Ojan
   Koulas, Spyridon
   Hirsch, Kornelia
   Basic, Jelena
   Assadian, Afshin
TI Randomized controlled trial comparing the combination of a polymeric
   membrane dressing plus negative pressure wound therapy against negative
   pressure wound therapy alone: The WICVAC study
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PAIN; INFECTIONS; MANAGEMENT; BLIND; FOAM
AB Negative pressure wound therapy (NPWT) is the treatment of choice for chronic wounds; yet, it is associated with considerable workload. Prompted by its nonadhesive and wound-healing properties, this study investigated the effect of an additional polymeric membrane interface dressing (PMD; PolyMem WIC) in NPWT. From October 2011 to April 2013, 60 consecutive patients with chronic leg wounds or surgical site infections after revascularization of lower extremities were randomly allocated to either treatment with conventional NPWT (control arm) or NPWT with an additional PMD (intervention arm). The primary outcome was wound healing achieved within 30 days, the secondary endpoints included: number of days between dressing changes, wound-related pain, cost efficiency, and occurrence of adverse events ( Identifier: NCT02399722). Forty-seven patients completed follow-up. No difference in wound healing was observed (p>0.05) between both study arms. The additional PMD allowed significantly longer wearing times (days) between dressing changes (intervention: 8.8 +/- 0.5, control: 4.8 +/- 0.2; p<0.001). Pain was slightly higher in patients randomized to NPWT alone (VAS score: 4.8 +/- 2.9) compared to NPWT+PMD (VAS score: 3.0 +/- 2.9, p=0.063). No wound infections were observed. Costs were reduced by 34% per patient in the intervention arm. These results suggest that the combination of NPWT and an additional interface PMD is a safe and economic method for the treatment of chronic wounds, which requires significantly fewer dressing changes for a comparable wound healing.
C1 [Skrinjar, Edda; Bayer, Gottfried S.; Koulas, Spyridon; Hirsch, Kornelia; Basic, Jelena; Assadian, Afshin] Wilhelminenhospital, Dept Vasc & Endovasc Surg, Pavillon 30B Montleartstr 37, A-1160 Vienna, Austria.
   [Duschek, Nikolaus] CHU Vaudois, Dept Dermatol & Venerol, Lausanne, Vaud, Switzerland.
   [Assadian, Ojan] Univ Huddersfield, Inst Skin Integr & Infect Prevent, Sch Human & Hlth Sci, Huddersfield, W Yorkshire, England.
C3 Wilhelminenspital; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Huddersfield
RP Skrinjar, E (通讯作者)，Wilhelminenhospital, Dept Vasc & Endovasc Surg, Pavillon 30B Montleartstr 37, A-1160 Vienna, Austria.
EM edda.skrinjar@gmx.at
RI Assadian, Ojan/H-9753-2019; Duschek, Nikolaus/KHX-7082-2024
OI Assadian, Ojan/0000-0003-0129-8761; Assadian, Ojan/0000-0003-0129-8761; 
FU Ferris Mfg. Corporation
FX Dr. Skrinjar received a travel grant from Ferris Mfg. Corporation for
   presenting preliminary findings of this evaluation at the EWMA
   Conference 2010.
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NR 27
TC 4
Z9 4
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP-OCT
PY 2016
VL 24
IS 5
BP 928
EP 935
DI 10.1111/wrr.12457
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DY9WD
UT WOS:000385485100019
PM 27313054
DA 2026-07-24
ER
PT J
AU Lynam, S
   Mark, KS
   Temkin, SM
AF Lynam, Sarah
   Mark, Katrina S.
   Temkin, Sarah Madhu
TI Primary Placement of Incisional Negative Pressure Wound Therapy at Time
   of Laparotomy for Gynecologic Malignancies
SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
LA English
DT Article
DE Closed incision; Negative pressure wound therapy; Surgical site
   infections; Laparotomy; Quality improvement
ID SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED CLOSURE; OBESE WOMEN; SURGERY;
   COMPLICATIONS; PREDICTORS; IMPACT; COSTS
AB Objective Wound complications are an important cause of postoperative morbidity amongst patient with gynecologic malignancies. We evaluated whether the placement of prophylactic negative pressure wound therapy (NPWT) at the time of laparotomy for gynecologic cancer surgery reduces wound complication rates.
   Methods A retrospective analysis of patients undergoing laparotomy with primary wound closure performed by a gynecologic oncologist at a single academic institution over a 5-year study period was performed. Patients who had placement of prophylactic NPWT dressing were compared with patients with a standard closure. Postoperative outcomes were examined.
   Results A total of 230 patients were identified: 208 women received standard wound care, 22 received NPWT. Groups were similar in age, prevalence of diabetes, tobacco use, and number of previous abdominal procedures. Intraoperative factors including length of procedure and transfusion requirements were similar. Body mass index for patients receiving standard treatment was 30.67 compared with 41.29 for NPWT group (P < 0.001). Incidence of all wound complications was 19.7% for those receiving standard treatment versus 27.3% for NPWT group (P = 0.40). Length of hospital stay was similar between the 2 groups (5.25 vs 6.22 days, P = 0.20). There were 3 hospital readmissions for wound complicationsnone occurred in women with a prophylactic NPWT dressing.
   Conclusions Despite significantly higher obesity rates, patients with prophylactic NPWT dressing placement had similar rates of wound complications. Our findings suggest a potential therapeutic benefit in the use of prophylactic NPWT for the reduction of wound complications in this high-risk gynecologic oncology patient population.
C1 [Lynam, Sarah; Mark, Katrina S.; Temkin, Sarah Madhu] Univ Maryland, Sch Med, Dept Obstet Gynecol & Reprod Sci, Baltimore, MD 21201 USA.
   [Temkin, Sarah Madhu] Johns Hopkins Univ Hosp, Dept Gynecol & Obstet, Baltimore, MD 21287 USA.
C3 University System of Maryland; University of Maryland Baltimore; Johns
   Hopkins University; Johns Hopkins Medicine
RP Temkin, SM (通讯作者)，600 North Wolfe St,Phipps 281, Baltimore, MD 21287 USA.
EM stemkin1@jhmi.edu
OI Lynam, Sarah/0000-0003-1474-6527; Mark, Katrina/0000-0001-5127-2936
CR [Anonymous], 2016, Cancer facts and figures 2016
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   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
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NR 26
TC 18
Z9 19
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1048-891X
EI 1525-1438
J9 INT J GYNECOL CANCER
JI Int. J. Gynecol. Cancer
PD OCT
PY 2016
VL 26
IS 8
BP 1525
EP 1529
DI 10.1097/IGC.0000000000000792
PG 5
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA DZ2IL
UT WOS:000385665400026
PM 27488215
DA 2026-07-24
ER
PT J
AU Zuo, YH
   Lu, SL
AF Zuo, Yanhai
   Lu, Shuliang
TI A universal skin stretcher inspired by a wheel and a hypothesis for
   large wound closure
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE External expansion; skin stretcher; negative pressure wound therapy;
   wound closure
ID VACUUM-ASSISTED CLOSURE; VISCOELASTIC PROPERTIES; DEVICE; FIXATION
AB Existing skin stretchers merely allow the skin expansion in the opposite directions. This study was designed to present and evaluate a modified skin stretcher (the universal skin stretcher) that enabled the skin expansion in any direction in a controlled way. Four types of the universal skin stretcher were assembled and employed on the wound of a bama pig at the suction pressure of -20 KPa. The stability of the device was assessed on a piece of wounded pig kin at different suction pressures (-20 KPa, -25 KPa, -30 KPa, -35 KPa, and -40 KPa respectively). The primary outcome measures: the weight it withstands in the horizontal direction (W-h) and the vertical direction (W-v). It was observed that any part of the universal skin stretcher can be cut and assembled into different sizes easily. At the suction pressure of -20 KPa, all four types of the universal skin stretcher can be installed on anywhere of the wounds by negative pressure. Both the W-h and W-v increased with either the suction pressures or sizes of the universal skin stretcher. The results show that the universal skin stretcher can be used easily and withstand satisfactory weight that is deemed to be relatively safe for skin expansion.
C1 [Zuo, Yanhai; Lu, Shuliang] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Shanghai Burns Inst, 197 Rui Jin 2nd Rd, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University
RP Zuo, YH; Lu, SL (通讯作者)，Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Shanghai Burns Inst, 197 Rui Jin 2nd Rd, Shanghai 200025, Peoples R China.
EM zuoyanhai@sina.cn; 1390173-8685@139.com
FU China National Nature Scientific Grants [81071566, 81000838]; National
   Key Project for Fundamental Research and Development (973 Project)
   [2012CB518105]; National Science & Technology Pillar Program
   [2012BAI11B00]; Health industry scientific research special project
   [201202002]; Research and Innovation project of Shanghai Municipal
   Education Commission [14YZ040]
FX This study was supported by China National Nature Scientific Grants (No.
   81071566, 81000838), National Key Project for Fundamental Research and
   Development (973 Project) (No. 2012CB518105), National Science &
   Technology Pillar Program (No. 2012BAI11B00), Health industry scientific
   research special project (No. 201202002), Research and Innovation
   project of Shanghai Municipal Education Commission (Grant No. 14YZ040).
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NR 21
TC 0
Z9 0
U1 0
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2016
VL 9
IS 8
BP 16387
EP 16392
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DZ4OJ
UT WOS:000385837700165
DA 2026-07-24
ER
PT J
AU Kim, DY
   Park, SJ
   Bang, SI
   Mun, GH
   Pyon, JK
AF Kim, Dae Young
   Park, Sun-June
   Bang, Sa-Ik
   Mun, Goo-Hyun
   Pyon, Jai-Kyong
TI Does the Use of Incisional Negative-Pressure Wound Therapy Prevent
   Mastectomy Flap Necrosis in Immediate Expander-Based Breast
   Reconstruction?
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID ACELLULAR DERMAL MATRIX; TISSUE EXPANDER; SPARING MASTECTOMY; SURGICAL
   INCISIONS; HIGH-RISK; COMPLICATIONS; SKIN; METAANALYSIS; EXPERIENCE;
   MANAGEMENT
AB Background: Mastectomy flap necrosis is one of the most common and significant complications in immediate expander-based breast reconstruction. Negative-pressure wound therapy is widely used for open wounds but is not commonly used for closed incisional wounds. However, the postoperative use of incisional negative-pressure wound therapy is demonstrated to reduce complication rates. The authors evaluate the incidence of mastectomy flap necrosis in patients with incisional negative-pressure wound therapy after immediate expander-based breast reconstruction compared with the incidence in patients with conventional dressing.
   Methods: A retrospective review was conducted to identify patients who underwent immediate expander-based breast reconstruction between January of 2010 and February of 2015 at a single institution. Patients were divided into a conventional dressing group and an incisional negative-pressure wound therapy group. Patient demographics, intraoperative findings, and complications were compared between the two groups.
   Results: A total of 228 breasts (206 patients) were included in this study. Of these, the incisional negative-pressure wound therapy group included 45 breasts (44 patients) and the conventional dressing group included 183 breasts (162 patients). The incisional negative-pressure wound therapy group had a lower overall complication rate (11.1 percent versus 27.9 percent; p = 0.019), overall mastectomy flap necrosis rate (8.9 percent versus 23.5 percent; p = 0.030), and major mastectomy flap necrosis rate (2.2 percent versus 13.7 percent; p = 0.031) compared with the conventional dressing group.
   Conclusions: Incisional negative-pressure wound therapy reduced the incidence of mastectomy flap necrosis. This simple and reliable dressing technique can be effective in preventing mastectomy flap necrosis in immediate expander-based breast reconstruction.
C1 [Pyon, Jai-Kyong] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Plast Surg, 81 Irwon Ro, Seoul 135710, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Pyon, JK (通讯作者)，Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Plast Surg, 81 Irwon Ro, Seoul 135710, South Korea.
EM pspriest.pyon@samsung.com
RI Mun, Goo-Hyun/I-2540-2019
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NR 39
TC 50
Z9 54
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2016
VL 138
IS 3
BP 558
EP 566
DI 10.1097/PRS.0000000000002431
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DZ7BH
UT WOS:000386017900054
PM 27556600
DA 2026-07-24
ER
PT J
AU Sziklavari, Z
   Ried, M
   Zeman, F
   Grosser, C
   Szöke, T
   Neu, R
   Schemm, R
   Hofmann, HS
AF Sziklavari, Zsolt
   Ried, Michael
   Zeman, Florian
   Grosser, Christian
   Szoke, Tamas
   Neu, Reiner
   Schemm, Rudolf
   Hofmann, Hans-Stefan
TI Short-term and long-term outcomes of intrathoracic vacuum therapy of
   empyema in debilitated patients
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; VAC; Vacuum-assisted closure;
   Intrapleural; Intrathoracic; Empyema
ID OPEN-WINDOW THORACOSTOMY; ASSISTED CLOSURE THERAPY; PLEURAL EMPYEMA;
   LUNG RESECTION; INSTILLATION
AB Background: This retrospective study analyzed the effectiveness of intrathoracic negative pressure therapy for debilitated patients with empyema and compared the short-term and long-term outcomes of three different intrapleural vacuum-assisted closure (VAC) techniques.
   Methods: We investigated 43 consecutive (pre) septic patients with poor general condition (Karnofsky index <= 50 %) and multimorbidity (>= 3 organ diseases) or immunosuppression, who had been treated for primary, postoperative, or recurrent pleural empyema with VAC in combination with open window thoracostomy (OWT-VAC) with minimally invasive technique (Mini-VAC), and instillation (Mini-VAC-Instill).
   Results: The overall duration of intrathoracic vacuum therapy was 14 days (5-48 days). Vacuum duration in the Mini-VAC and Mini-VAC-Instill groups (12.4 +/- 5.7 and 10.4 +/- 5.4 days) was significantly shorter (p = 0.001) than in the group treated with open window thoracostomy (OWT)-VAC (20.3 +/- 9.4 days). No major complication was related to intrathoracic VAC therapy. Chest wall closure rates were significantly higher in the Mini-VAC and Mini-VAC-Instill groups than in the OWT-VAC group (p = 0.034 and p = 0.026). Overall, the mean postoperative length of stay in hospital (LOS) was 21 days (median 18, 6-51 days). LOS was significantly shorter (p = 0.027) in the Mini-VAC-Instill group (15.1 +/- 4.8) than in the other two groups (23.8 +/- 12.3 and 22.7 +/- 1.5). Overall, the 30-day and 60-day mortality rates were 4.7 % (2/43) and 9.3 % (4/43), and none of the deaths was related to infection.
   Conclusions: For debilitated patients, immediate minimally invasive intrathoracic vacuum therapy is a safe and viable alternative to OWT. Mini-VAC-Instill may have the fastest clearance and healing rates of empyema.
C1 [Sziklavari, Zsolt; Grosser, Christian; Szoke, Tamas; Schemm, Rudolf; Hofmann, Hans-Stefan] Krankenhaus Barmherzige Bruder Regensburg, Dept Thorac Surg, Prufeningerstr 86, D-93049 Regensburg, Germany.
   [Ried, Michael; Neu, Reiner; Hofmann, Hans-Stefan] Univ Med Ctr Regensburg, Dept Thorac Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
   [Zeman, Florian] Univ Med Ctr Regensburg, Ctr Clin Studies, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
C3 University of Regensburg; University of Regensburg
RP Sziklavari, Z (通讯作者)，Krankenhaus Barmherzige Bruder Regensburg, Dept Thorac Surg, Prufeningerstr 86, D-93049 Regensburg, Germany.
EM sziklavari_zsolt@yahoo.com
RI Ried, Michael/AAC-4518-2022; Zeman, Florian/GNH-3239-2022; Sziklavari,
   Zsolt/AGI-2440-2022
OI Ried, Michael/0000-0002-2365-4803; Zeman, Florian/0000-0002-8425-984X; 
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NR 14
TC 16
Z9 22
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD OCT 21
PY 2016
VL 11
AR 148
DI 10.1186/s13019-016-0543-7
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA DZ8BQ
UT WOS:000386094000001
PM 27769303
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Neas, ED
   Dunn, JA
   Silva, ED
   Chambers, AM
   Luckasen, GJ
   Jaskowiak, A
AF Neas, Edwin D.
   Dunn, Julie A.
   Silva, Evelyn Dimaano
   Chambers, A. Morgan
   Luckasen, Gary J.
   Jaskowiak, Adam
TI Peroxy Pyruvic Acid-Containing Topical Anti-Infective: A Potential
   Candidate for a Wound Instillation Solution
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE peroxy-pyruvic acid; PPA; wound instillation; topical anti-infective;
   chronic wound; microbial biofilm
ID STAPHYLOCOCCUS-SIMULANS; CLINICAL-SIGNIFICANCE; SERRATIA-MARCESCENS;
   BACILLUS-CEREUS; INFECTIONS; SUSCEPTIBILITY; PATHOGEN; CARE; MORGANELLA;
   COMMUNITY
AB Objective: Evaluate the therapeutic properties of a peroxy pyruvic acid (PPA)-containing topical anti-infective in a human ex-vivo model that replicates the natural conditions of a human chronic wound. Approach: Wound material was extracted from patients with nonhealing diabetic ulcers, venous stasis ulcers, and arterial wounds. Microbial species were identified, and wound colonization was quantified. Extracted samples were then exposed to a PPA-containing topical anti-infective as an instillation solution with negative pressure wound therapy NPWT at concentrations of 1,000, 1,500, or 2,500ppm for a period of 1, 5, or 10min to determine the effect of exposure on isolated pathogens, including effect on proteins. Results: A total of 32 samples were collected from patients. Samples presented with a range of bacteria and fungi representing 14 genera and 22 species, many of which are or are evolving to be resistant to many, if not most, current systemic antibiotics. Thirteen of twenty-three samples (57%) from chronic wounds had bacteria counts 10(5) and most were 6logs or more. Seven of 10 samples (70%) from acute wounds had bacteria counts 10(5) and most were much lower. Exposure to PPA-containing topical anti-infective at 1,000ppm killed all bacteria and fungi in all samples within 1min of exposure. Innovation: PPA-containing topical anti-infective is a potentially valuable clinical option for NPWT. Conclusion: PPA-containing topical anti-infective is a potential candidate for use as an NPWT instillation solution for the treatment of wound infections caused by susceptible pathogens.
C1 [Neas, Edwin D.; Silva, Evelyn Dimaano; Chambers, A. Morgan] CHD Biosci Inc, 2950 East Harmony Rd,Suite 252, Ft Collins, CO 80528 USA.
   [Dunn, Julie A.] UC Hlth, Medial Ctr Rockies, Loveland, CO USA.
   [Luckasen, Gary J.; Jaskowiak, Adam] UC Hlth Res, Med Ctr Rockies, Loveland, CO USA.
RP Neas, ED (通讯作者)，CHD Biosci Inc, 2950 East Harmony Rd,Suite 252, Ft Collins, CO 80528 USA.
EM ed.neas@chdbioscience.com
FU CHD Bioscience, Inc.; Acelity
FX The authors gratefully acknowledge Brian G. Bass for editorial
   assistance in the preparation of this article. Funding for the
   preparation of this article was provided by CHD Bioscience, Inc. The
   preclinical study was co-funded with Acelity.
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   Zhao G, 2013, ADV WOUND CARE, V2, P389, DOI 10.1089/wound.2012.0381
NR 51
TC 2
Z9 3
U1 1
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD OCT
PY 2016
VL 5
IS 10
BP 432
EP 443
DI 10.1089/wound.2015.0682
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DZ9SP
UT WOS:000386219400002
PM 27785377
DA 2026-07-24
ER
PT J
AU Maeda, T
   Yamamoto, Y
   Tanaka, S
   Hayashi, T
AF Maeda, Taku
   Yamamoto, Yuhei
   Tanaka, Soichi
   Hayashi, Toshihiko
TI Application of Vacuum-Assisted Closure Therapy and Hyperbaric Oxygen
   Therapy for an Exposed Titanium Plate After Mandible Reconstruction
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Craniofacial wound; exposed mandibular plate; hyperbaric oxygen therapy;
   vacuum-assisted closure
ID BONE MORPHOGENETIC PROTEIN-2; CLINICAL-EXPERIENCE; FREE-FLAP; DEFECTS;
   WOUNDS; HEAD
AB The authors report a case of an 84-year-old woman with an exposed mandibular plate after reconstruction, which finally healed with combination therapy using vacuum-assisted closure therapy and hyperbaric oxygen therapy. The woman was diagnosed with mucosal carcinoma of the right oral cavity. During reconstruction after segmental excision of the mandible, a titanium plate was selected based on several risk factors. After the operation, the plate became exposed at the center of the chin. A second surgery was deemed inappropriate because of her age, malnutrition, and recurrent aspiration pneumonia. Instead, combination therapy consisting of vacuum-assisted closure therapy and hyperbaric oxygen therapy was initiated, leading to epithelizaion of the wound. Adapt Barrier Rings was effectively used to generate a stable negative pressure at the complicated craniofacial wound. A surgical or conservative approach is chosen as salvage treatment of an exposed plate. In this patient, only conservative treatment involving combination therapy resulted in complete healing of the wound with plate exposure. This patient highlights 2 important clinical issues: combination therapy was effective for an exposed mandibular plate, and a dressing technique using Adapt Barrier Rings enabled stable negative pressure in the craniofacial wound.
C1 [Maeda, Taku; Yamamoto, Yuhei; Hayashi, Toshihiko] Hokkaido Univ, Grad Sch Med, Dept Plast & Reconstruct Surg, Sapporo, Hokkaido, Japan.
   [Tanaka, Soichi] Hokkaido Univ, Grad Sch Dent Med, Div Oral Pathobiol, Dept Oral & Maxillofacial Surg, Sapporo, Hokkaido, Japan.
C3 Hokkaido University; Hokkaido University
RP Hayashi, T (通讯作者)，107 Nishi 7 Chome,Kita 15 Jo,Kita Ku, Sapporo, Hokkaido, Japan.
EM toshi-116@nifty.com
RI Hayashi, Toshihiko/AAU-9776-2020
OI Hayashi, Toshihiko/0000-0002-1180-1685; MAEDA, TAKU/0000-0003-3612-8201
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Boyd Travis G, 2012, Eplasty, V12, pe42
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NR 13
TC 4
Z9 4
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD OCT
PY 2016
VL 27
IS 7
BP E601
EP E604
DI 10.1097/SCS.0000000000002917
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EA1KW
UT WOS:000386352100006
PM 27464555
DA 2026-07-24
ER
PT J
AU Chik, I
   Kelly, EG
   Jarmin, R
   Imran, FH
AF Chik, Ian
   Kelly, Enda G.
   Jarmin, Razman
   Imran, Farrah-Hani
TI The Hanikoda Method: 3-layered Negative Pressure Wound Therapy in Wound
   Bed Preparation
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; Hanikoda Method
ID VACUUM-ASSISTED CLOSURE
AB Introduction. Negative pressure wound therapy is a widely used method of wound dressing with various commercially available brands. The authors created the Hanikoda Method (HM) for effective wound bed preparation or definite wound closure. Methods. In this case series, the authors discuss 8 different wound cases that presented to their Plastics Unit from January 2014 to June 2015. Patients with traumatic or infected wounds were selected for treatment with the HM. Selected patients underwent multiple cycles of this method until their wounds were ready for definite wound closure or the wounds had closed by secondary closure. Discussion. The purpose of any wound dressing is to encourage epithelization while ensuring no factors impede wound healing. An additional benefit is to reduce wound bed size so that it may close by secondary intention or require less skin graft coverage. Each layer of the dressing is described, along with its function in wound bed preparation or in closure. Conclusion. The HM facilitates reduction of wound size, wound bed preparation, and overall management.
C1 [Chik, Ian; Jarmin, Razman; Imran, Farrah-Hani] Univ Kebangsaan Malaysia, Med Ctr, Kuala Lumpur, Malaysia.
   [Kelly, Enda G.] Cappagh Natl Orthopaed Hosp, Dublin, Ireland.
C3 Universiti Kebangsaan Malaysia
RP Imran, FH (通讯作者)，Natl Univ Malaysia, Dept Surg, Plast Reconstruct Surg Burns & Wound Teams, Fac Med,Univ Kebangsaan Malaysia,Med Ctr, Jalan Yaakob Latiff, Kuala Lumpur 56000, Malaysia.
EM farrahhani@gmail.com
RI Imran, Farrah-Hani/AAF-3570-2019
OI Imran, Farrah-Hani/0000-0001-8127-0309; kelly, enda/0000-0001-9697-4982
CR Hilton JR, 2004, CLIN INFECT DIS, V39, pS100, DOI 10.1086/383270
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Joseph E, 2000, WOUNDS, V12, P60
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Payne Caroline, 2014, Eplasty, V14, pe20
   Thomas S, 1995, Ostomy Wound Manage, V41, P54
   Thomas S, 1995, OSTOMY WOUND MANAG, V41, P58
NR 7
TC 1
Z9 2
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2016
VL 28
IS 10
BP 360
EP 368
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EA2HD
UT WOS:000386412500005
PM 27768574
DA 2026-07-24
ER
PT J
AU Wang, T
   He, R
   Zhao, J
   Gu, QS
   Mei, JC
   Shao, MZ
   Pan, Y
   Zhang, J
   Wu, HS
   Yu, M
   Yang, WC
   Liu, LM
   Liu, F
   Jia, WP
AF Wang, Tao
   He, Rui
   Zhao, Jun
   Gu, Qisheng
   Mei, Jiacai
   Shao, Mingzhe
   Pan, Ye
   Zhang, Jian
   Wu, Haisheng
   Yu, Min
   Yang, Wenchao
   Liu, Limei
   Liu, Fang
   Jia, Weiping
TI A prospective cohort study of negative pressure wound therapy combined
   angioplasty for diabetic foot patients with critical limb ischemia
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Negative pressure wound therapy; percutaneous angioplasty; diabetic
   ulcer; critical limb ischemia
ID VACUUM-ASSISTED CLOSURE; BALLOON ANGIOPLASTY; ULCERS; MULTICENTER;
   MANAGEMENT; DISEASE; PREVALENCE
AB To evaluate the clinical efficacy and security of combined negative pressure wound therapy (NPWT) and percutaneous angioplasty (PTA) in the treatment of diabetic foot ulcers with critical limb ischemia (CLI). We enrolled 97 patients from 142 cases suffered from diabetic foot ulcers into this multi-center prospective cohort study. Patients who were assigned to NPWT-PTA (n=56) or NPWT (n=41) group based on standard off-leading therapy as needed, and were followed-up at 8 weeks and 20 weeks, their ankle-brachial pressure index (ABI), wound area, healing time and adverse events were monitored. A multivariate Cox proportional hazards regression analysis was used to determining the risk factors of wound healing. A greater proportion of wound healing in NPWT-PTA group was observed compared with NPWT group (61.5% vs 40.9%, P=0.004) at 20 weeks. The time of wound healing was earlier in NPWT-PTA group than NPWT group (48.3 +/- 32.8 days vs 77.1 +/- 27.1 days, P=0.009) at 20 weeks. ABI in NPWT-PTA group was higher than NPWT group at both 8 weeks (0.83 +/- 0.19 vs 0.46 +/- 0.15, P=0.000) and 20 weeks (0.72 +/- 0.17 vs 0.53 +/- 0.12, P=0.000). The decrease of ABI (HR=15.000, 95% CI=2.243-100.333, P=0.005) and increase of wound area (HR=0.926, 95% CI=0.866-0.990, P=0.025) were independent risk factors of wound healing. There was no significant difference in adverse events between the two groups. Combined NPWT with PTA therapy is effective and safe for diabetic foot ulcers with CLI by increasing the level of ABI, and results in a higher proportion of wounds closure.
C1 [Wang, Tao; Zhao, Jun; Mei, Jiacai; Shao, Mingzhe; Pan, Ye; Zhang, Jian; Wu, Haisheng; Yu, Min; Yang, Wenchao] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp Shanghai 6, Shanghai Clin Med Ctr Diabet, Dept Vasc Surg,Multidisciplinary Collaborat Ctr D, 600 Yishan Rd, Shanghai 200233, Peoples R China.
   [He, Rui; Liu, Limei; Liu, Fang; Jia, Weiping] Shanghai Jiao Tong Univ, Shanghai Key Clin Ctr Metab Dis,Afflliated People, Shanghai Key Lab Diabet,Shanghai Clin Med Ctr Dia, Multidisciplinary Collaborat Grp Diabet Foot,Shan, Shanghai 200233, Peoples R China.
   [Gu, Qisheng] Shanghai Qisheng Inst Biol Mat Res, Shanghai 201100, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Zhao, J (通讯作者)，Shanghai Jiao Tong Univ, Affiliated Peoples Hosp Shanghai 6, Shanghai Clin Med Ctr Diabet, Dept Vasc Surg,Multidisciplinary Collaborat Ctr D, 600 Yishan Rd, Shanghai 200233, Peoples R China.; Liu, F (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Key Clin Ctr Metab Dis,Afflliated People, Shanghai Key Lab Diabet,Shanghai Clin Med Ctr Dia, Multidisciplinary Collaborat Grp Diabet Foot,Shan, Shanghai 200233, Peoples R China.
EM junnzhao@126.com; f-liu@sjtu.edu.cn
RI Jia, Weiping/B-7483-2012; Yang, Wen-Chao/U-1649-2019; Wu,
   Haisheng/KBC-9542-2024; shao, mingzhe/NWH-1124-2025; He,
   Ruijia/MZQ-2297-2025
OI Jia, Weiping/0000-0002-6244-2168; 
FU Natural Science Foundation of China [8127-0397]; Fund of Shanghai Health
   Bureau [201344197]
FX The authors are thankful to Shanghai Key Laboratory of Diabetes for
   providing necessary help for carrying out the research work. The present
   study was supported by grants from Natural Science Foundation of China
   (8127-0397 for Fang Liu) and Fund of Shanghai Health Bureau (No
   201344197 for Jian Zhang).
CR Alexandrescu V, 2009, EUR J VASC ENDOVASC, V37, P448, DOI 10.1016/j.ejvs.2008.12.005
   [Anonymous], 2004, WOUNDS, p3S
   Armstrong DG, 2003, DIABETIC MED, V20, P329, DOI 10.1046/j.1464-5491.2003.00933.x
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NR 30
TC 0
Z9 0
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2016
VL 9
IS 9
BP 17975
EP 17984
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EA5OT
UT WOS:000386671100101
DA 2026-07-24
ER
PT J
AU Manoharan, V
   Grant, AL
   Harris, AC
   Hazratwala, K
   Wilkinson, MPR
   McEwen, PJC
AF Manoharan, Varaguna
   Grant, Andrea L.
   Harris, Alicia C.
   Hazratwala, Kaushik
   Wilkinson, Matthew P. R.
   McEwen, Peter J. C.
TI Closed Incision Negative Pressure Wound Therapy vs Conventional Dry
   Dressings After Primary Knee Arthroplasty: A Randomized Controlled Study
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE negative pressure wound therapy; primary knee arthroplasty; quality of
   life; cost; wound complications
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS; HIP; INFECTION; MANAGEMENT;
   SURGERY; REPLACEMENT
AB Background: The purpose of this study was to assess the effect of negative pressure wound therapy (NPWT) on quality of life (QoL), wound complications, and cost after primary knee arthroplasty.
   Methods: A prospective analysis of 33 patients undergoing primary knee arthroplasty performed by 3 surgeons in one institution. The first 12 patients (3 bilateral and 9 unilateral) had conventional dry dressings (CDD) applied and cost of dressings was assessed. The other 21 patients all underwent bilateral knee arthroplasty and had either side randomized to receiving NPWT or CDD. Cost of dressings, wound complications, and QoL were compared.
   Results: One patient had a reaction to the NPWT requiring readmission. Another had persistent wound drainage that required NPWT application. There were no wound issues in the remaining 31 patients. The average cost in the first 12 patients was Australian dollar $48.70 with an average of 1.5 changes on ward. In the 21 patients receiving both dressings, the average cost for CDD was less (Australian dollar $43.51 vs $396.02, P <= .011, effect size [ES] = 1.06). When comparing QoL factors, wound leakage (0.14 vs 0.39 P = .019, ES = 1.02), and wound protection (0.16 vs 0.33, P = .001, ES = 0.021) were better in the NPWT group. There was no other significant difference in QoL factors. The average number of changes on the ward was less for the NPWT group (1.19 vs 1.38, P = .317, ES = 1.02).
   Conclusion: We found no benefit in wound healing or cost with NPWT post knee arthroplasty. There was some benefit in NPWT QoL factors less wound leakage and better protection. Crown Copyright (C) 2016 Published by Elsevier Inc. All rights reserved.
C1 [Manoharan, Varaguna; Grant, Andrea L.; Harris, Alicia C.; Hazratwala, Kaushik; Wilkinson, Matthew P. R.; McEwen, Peter J. C.] Orthopaed Res Inst Queensland ORIQL, Pimlico, Qld, Australia.
   [Manoharan, Varaguna; Grant, Andrea L.; Harris, Alicia C.; Hazratwala, Kaushik; Wilkinson, Matthew P. R.; McEwen, Peter J. C.] Mater Hlth Serv North Queensland Ltd, Pimlico, Qld, Australia.
   [Manoharan, Varaguna; Hazratwala, Kaushik; Wilkinson, Matthew P. R.; McEwen, Peter J. C.] Townsville Hosp, Dept Orthopaed, Townsville, Qld, Australia.
C3 Mater Health Services; Queensland Health; Townsville Hospital
RP Manoharan, V (通讯作者)，Orthopaed Res Inst Queensland, 7 Turner St, Pimlico, Qld 4812, Australia.
RI McEwen, Peter/LIC-3848-2024
OI McEwen, Peter/0000-0001-5499-9532; Hazratwala,
   Kaushik/0000-0002-0649-9231; Grant, Andrea/0000-0002-0568-0872;
   Wilkinson, Matthew/0000-0002-3704-7043
CR [Anonymous], 2012, STRYKER ACCOLADE 2 F
   Australian Orthopaedic Association National Joint Replacement Registry, 2014, REV HIP KNEE ARTH S
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NR 37
TC 56
Z9 61
U1 0
U2 3
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD NOV
PY 2016
VL 31
IS 11
BP 2487
EP 2494
DI 10.1016/j.arth.2016.04.016
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA EA6OG
UT WOS:000386747900021
PM 27341973
DA 2026-07-24
ER
PT J
AU Qu, WQ
   Ni, SQ
   Wang, ZH
   Zhao, Y
   Zhang, SM
   Cheng, YH
   Liu, T
   Yu, M
   Wang, D
AF Qu, Wenqing
   Ni, Shuqin
   Wang, Zhenhai
   Zhao, Yong
   Zhang, Shimin
   Cheng, Yiheng
   Liu, Tong
   Yu, Min
   Wang, Dan
TI Severe open Lisfranc injuries: one-stage operation through internal
   fixation associated with vacuum sealing drainage
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Lisfranc joints injury; Openness; k-wire internal fixation; VSD
ID OPEN REDUCTION; PRIMARY ARTHRODESIS
AB Background: This study aimed to investigate the clinical feasibility of treating severe open Lisfranc injuries by means of one-stage internal fixation with k-wires associated with vacuum sealing drainage (VSD).
   Methods: The clinical outcomes of 20 cases of severe open Lisfranc joint fracture-dislocation treated by using one-stage internal fixation with k-wires associated with VSD, after debridement and suturing during emergency treatment, were reviewed.
   Results: At 6 and 12 months after surgery, the American Orthopaedic Foot and Ankle Society midfoot scores were 69.2 and 78.2, the positive rates were 75 and 85 %, and the average visual analogue scale scores were 4.3 and 1.3, respectively. The average time of internal fixation surgery was 47 min (30-70 min). There were three cases of wound-edge necrosis; however, there were no cases of skin necrosis around the incision, or deep infection. The mean time of first hospital stay was 16.1 days (10-23 days).
   Conclusions: Treatment of severe open Lisfranc fracture and dislocation through one-stage internal fixation with k-wires in association with VSD led to fast anatomical reduction, stabilized bony structure, fast soft tissue recovery, and good short-term follow-up results.
C1 [Qu, Wenqing; Ni, Shuqin; Wang, Zhenhai; Zhao, Yong; Cheng, Yiheng; Liu, Tong; Yu, Min; Wang, Dan] Yantaishan Hosp, Dept Orthopaed & Trauma, Yantai 264008, Peoples R China.
   [Zhang, Shimin] Tongji Univ, Yangpu Hosp, Dept Orthopaed, Shanghai 200090, Peoples R China.
C3 Tongji University
RP Wang, D (通讯作者)，Yantaishan Hosp, Dept Orthopaed & Trauma, Yantai 264008, Peoples R China.
EM danwangdoc@126.com
RI ZHANG, Shimin/NUP-4492-2025
CR Benirschke SK, 2012, J BONE JOINT SURG AM, V94A, P1326, DOI 10.2106/JBJS.L00413
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   Tarkin IS, 2008, INJURY, V39, P142, DOI 10.1016/j.injury.2007.07.024
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   Thompson Michael C, 2003, J Am Acad Orthop Surg, V11, P260
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NR 22
TC 11
Z9 17
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD NOV 4
PY 2016
VL 11
AR 134
DI 10.1186/s13018-016-0471-1
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA EB1DU
UT WOS:000387088300001
PM 27814724
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pericleous, A
   Dimitrakakis, G
   Photiades, R
   von Oppell, UO
AF Pericleous, Agamemnon
   Dimitrakakis, Georgios
   Photiades, Renos
   von Oppell, Ulrich O.
TI Assessment of vacuum-assisted closure therapy on the wound healing
   process in cardiac surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cardiac surgery; Risk factors; Sternal wound infection; VAC dressing;
   Wound healing
ID INTERNAL THORACIC ARTERY; POSTSTERNOTOMY MEDIASTINITIS; INFECTION;
   BYPASS; MANAGEMENT; MORTALITY; SKELETONIZATION; PATHOGENESIS;
   STERNOTOMY; GUIDELINES
AB Postoperative deep sternal wound infection (DSWI) is a serious complication in cardiac surgery (1-5% of patients) with high mortality and morbidity rates. Vacuum-assisted closure (VAC) therapy has shown promising results in terms of wound healing process, postoperative hospital length of stay and lower in-hospital costs. The aim of our retrospective study is to report the outcome of patients with DSWI treated with VAC therapy and to assess the effect of contributory risk factors. Data of 52 patients who have been treated with VAC therapy in a single institution (study period: September 2003-March 2012) were collected electronically through PAtient Tracking System PATS and statistically analysed using SPSS version 20. Of the 52 patients (35 M: 17 F), 88<bold></bold>5% (n = 46) were solely treated with VAC therapy and 11<bold></bold>5% (n = 6) had additional plastic surgical intervention. Follow-up was complete (mean 33<bold></bold>8 months) with an overall mortality rate of 26<bold></bold>9% (n = 14) of whom 50% (n = 7) died in hospital. No death was related to VAC complications. Patient outcomes were affected by pre-operative, intra-operative and postoperative risk factors. Logistic EUROscore, postoperative hospital length of stay, advanced age, chronic obstructive pulmonary disease (COPD) and long-term corticosteroid treatment appear to be significant contributing factors in the long-term survival of patients treated with VAC therapy.
C1 [Pericleous, Agamemnon] Cardiff Univ, Sch Med, Cardiff, S Glam, Wales.
   [Pericleous, Agamemnon; Dimitrakakis, Georgios; von Oppell, Ulrich O.] Univ Wales Hosp, Dept Cardiothorac Surg, Heath Pk, Cardiff CF14 4XW, S Glam, Wales.
   [Photiades, Renos] Univ Oxford, Dept Stat, Oxford, England.
C3 Cardiff University; Cardiff University; University of Oxford
RP Dimitrakakis, G (通讯作者)，Univ Wales Hosp, Dept Cardiothorac Surg, Heath Pk, Cardiff CF14 4XW, S Glam, Wales.
EM gdimitrakakis@yahoo.com
OI DIMITRAKAKIS, GEORGIOS/0000-0002-2426-7178
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NR 37
TC 5
Z9 8
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2016
VL 13
IS 6
BP 1142
EP 1149
DI 10.1111/iwj.12430
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8TQ
UT WOS:000387664400007
PM 25728664
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Nordmeyer, M
   Pauser, J
   Biber, R
   Jantsch, J
   Lehrl, S
   Kopschina, C
   Rapke, C
   Bail, HJ
   Forst, R
   Brem, MH
AF Nordmeyer, Matthias
   Pauser, Johannes
   Biber, Roland
   Jantsch, Jonathan
   Lehrl, Siegfried
   Kopschina, Carsten
   Rapke, Christian
   Bail, Hermann J.
   Forst, Raimund
   Brem, Matthias H.
TI Negative pressure wound therapy for seroma prevention and surgical
   incision treatment in spinal fracture care
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE NPWT; Spinal fracture; Wound complication; Wound healing
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; TRAUMA; DEFECT; BONE
AB To evaluate the clinical use and economic aspects of negative pressure wound therapy (NPWT) after dorsal stabilisation of spinal fractures. This study is a prospective randomised evaluation of NPWT in patients with large surgical wounds after surgical stabilisation of spinal fractures by internal fixation. Patients were randomised to either standard wound dressing treatment (group A) or NPWT (group B). The wound area was examined by ultrasound to measure seroma volumes in both groups on the 5th and 10th day after surgery. Furthermore, data on economic aspects such as nursing time for wound care and material used for wound dressing were evaluated. A total of 20 patients (10 in each group) were enrolled. Throughout the whole study, mean seroma volume was significantly higher in group A than that in group B (day 5: 1<bold></bold>9 ml versus 0 ml; P = 0<bold></bold>0007; day 10: 1<bold></bold>6 ml versus 0<bold></bold>5 ml; P <0<bold></bold>024). Furthermore, patients of group A required more wound care time (group A: 31 +/- 10 minutes; group B 13<bold></bold>8 +/- 6 minutes; P = 0<bold></bold>0005) and more number of compresses (total number; group A 35 +/- 15; group B 11 +/- 3; P = 0<bold></bold>0376). NPWT reduced the development of postoperative seroma, reduced nursing time and reduced material required for wound care.
C1 [Nordmeyer, Matthias; Pauser, Johannes; Biber, Roland; Kopschina, Carsten; Rapke, Christian; Bail, Hermann J.; Brem, Matthias H.] Klinikum Nuremberg, Dept Trauma & Orthopaed Surg, Nurnberg, Germany.
   [Pauser, Johannes] Univ Erlangen Nurnberg, Div Orthoped Rheumatol, Erlangen, Germany.
   [Jantsch, Jonathan] Univ Regensburg, Inst Med Microbiol & Hyg, Regensburg, Germany.
   [Lehrl, Siegfried] Friedrich Alexander Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany.
   [Forst, Raimund] Univ Hosp Erlangen, Dept Orthopaed Surg, Erlangen, Germany.
   [Brem, Matthias H.] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Div Trauma Surg, Dept Surg,Fac Med, Erlangen, Germany.
   Friedrich Alexander Univ Erlangen Nuernberg, Erlangen, Germany.
C3 Klinikum Nurnberg; University of Erlangen Nuremberg; University of
   Regensburg; University of Erlangen Nuremberg; University of Erlangen
   Nuremberg; University of Erlangen Nuremberg; University of Erlangen
   Nuremberg
RP Brem, MH (通讯作者)，Klinikum Nurnberg, Dept Orthopaed & Trauma Surg, Breslauer Str 201, D-90471 Nurnberg, Germany.
EM matthiasbrem@hotmail.de
RI Jantsch, Jonathan/KEE-9741-2024; Biber, Roland/AAP-6691-2021
OI Biber, Roland/0000-0002-7700-0311
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NR 25
TC 43
Z9 49
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2016
VL 13
IS 6
BP 1176
EP 1179
DI 10.1111/iwj.12436
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8TQ
UT WOS:000387664400012
PM 25932993
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Shi, B
   Sun, JJ
   Cao, YL
   Yang, F
   Wu, YJ
   Liang, XP
   Li, L
AF Shi, Bing
   Sun, Jingjing
   Cao, Yingli
   Yang, Fen
   Wu, Yujia
   Liang, Xianping
   Li, Li
TI Application of vacuum sealing drainage to the treatment of
   seawater-immersed blast-injury wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Blast injury; Macrophage; Seawater immersion; Vacuum sealing drainage;
   Wound healing rate
ID TOPICAL NEGATIVE-PRESSURE; RANDOMIZED-CONTROLLED-TRIAL; ASSISTED
   CLOSURE; STRATUM-CORNEUM; HYALURONIC-ACID; THERAPY; SKIN; EPIDERMIS;
   REPAIR; CD44
AB The aims of this study were to observe the effects of vacuum sealing drainage (VSD) with three different negative pressures on the wound healing rate, macrophage count and the expression of hyaluronic acid (HA) as well as its receptor CD44 in seawater-immersed blast-injury wounds (SIBIW) and to determine the optimal negative pressure value. In a minipig SIBIW model, different suction pressures and routine dressing were applied. Histological and immunohistochemical comparisons as well as molecular biology methods were performed to compare the wound healing conditions, macrophage count and the levels of HA and CD44. The wound healing rate of the VSD group was significantly higher than that of the control group, with the -120 mmHg group exhibiting the best effects. The macrophage count of the VSD group was higher than that of the control group. The HA level fluctuation was higher in the VSD group, with the -120 mmHg and the -180 mmHg groups showing the most significant fluctuation (P < 0<bold></bold>05). CD44 was expressed in the full-thickness wound-limbic tissues and was higher in the treatment group than that in the control group, with the -120 mmHg group having the most obvious expression. VSD significantly improved the healing ability and increased the macrophage count and the HA content. It also promoted CD44 expression. -120 mmHg is the optimal negative pressure value.
C1 [Shi, Bing; Sun, Jingjing; Cao, Yingli; Yang, Fen; Wu, Yujia; Liang, Xianping; Li, Li] PLA, Hosp 309, Dept Plast & Aesthet Surg, Beijing 100091, Peoples R China.
RP Shi, B (通讯作者)，PLA, Hosp 309, Dept Plast & Aesthet Surg, Beijing 100091, Peoples R China.
EM cnbingshi@163.com
RI wu, yujia/ISB-0310-2023
CR [Anonymous], 2011, IMMUNOBIOLOGY, DOI DOI 10.1016/j.imbio.2011.01.001
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   Chen S, 2005, ASIAN J SURG, V28, P213
   Cigna E, 2013, INT WOUND J, V10, P534, DOI 10.1111/j.1742-481X.2012.01011.x
   de Laat EHEW, 2011, ANN PLAS SURG, V67, P626, DOI 10.1097/SAP.0b013e31820b3ac1
   Dovi JV, 2003, J LEUKOCYTE BIOL, V73, P448, DOI 10.1189/jlb.0802406
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   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
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NR 21
TC 12
Z9 18
U1 1
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2016
VL 13
IS 6
BP 1198
EP 1205
DI 10.1111/iwj.12444
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8TQ
UT WOS:000387664400016
PM 25951775
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Scalise, A
   Calamita, R
   Tartaglione, C
   Pierangeli, M
   Bolletta, E
   Gioacchini, M
   Gesuita, R
   Di Benedetto, G
AF Scalise, Alessandro
   Calamita, Roberto
   Tartaglione, Caterina
   Pierangeli, Marina
   Bolletta, Elisa
   Gioacchini, Matteo
   Gesuita, Rosaria
   Di Benedetto, Giovanni
TI Improving wound healing and preventing surgical site complications of
   closed surgical incisions: a possible role of Incisional Negative
   Pressure Wound Therapy. A systematic review of the literature
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Closed wounds; Incisional Negative Pressure Wound Therapy; Surgical
   incision; Surgical wound infection; Wound healing
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; LONG-TERM SURVIVAL;
   HIGH-RISK; CARDIAC-SURGERY; EXCESS LENGTH; BLOOD-FLOW; POSTOPERATIVE
   MEDIASTINITIS; CDC DEFINITIONS; INFECTIONS
AB Advances in preoperative care, surgical techniques and technologies have enabled surgeons to achieve primary closure in a high percentage of surgical procedures. However, often, underlying patient comorbidities in addition to surgical-related factors make the management of surgical wounds primary closure challenging because of the higher risk of developing complications. To date, extensive evidence exists, which demonstrate the benefits of negative pressure dressing in the treatment of open wounds; recently, Incisional Negative Pressure Wound Therapy (INPWT) technology as delivered by Prevena (KCI USA, Inc., San Antonio, TX) and Pico (Smith & Nephew Inc, Andover, MA) systems has been the focus of a new investigation on possible prophylactic measures to prevent complications via application immediately after surgery in high-risk, clean, closed surgical incisions. A systematic review was performed to evaluate INPWT's effect on surgical sites healing by primary intention. The primary outcomes of interest are an understanding of INPWT functioning and mechanisms of action, extrapolated from animal and biomedical engineering studies and incidence of complications (infection, dehiscence, seroma, hematoma, skin and fat necrosis, skin and fascial dehiscence or blistering) and other variables influenced by applying INPWT (re-operation and re-hospitalization rates, time to dry wound, cost saving) extrapolated from human studies. A search was conducted for published articles in various databases including PubMed, Google Scholar and Scopus Database from 2006 to March 2014. Supplemental searches were performed using reference lists and conference proceedings. Studies selection was based on predetermined inclusion and exclusion criteria and data extraction regarding study quality, model investigated, epidemiological and clinical characteristics and type of surgery, and the outcomes were applied to all the articles included. 1 biomedical engineering study, 2 animal studies, 15 human studies for a total of 6 randomized controlled trials, 5 prospective cohort studies, 7 retrospective analyses, were included. Human studies investigated the outcomes of 1042 incisions on 1003 patients. The literature shows a decrease in the incidence of infection, sero-haematoma formation and on the re-operation rates when using INPWT. Lower level of evidence was found on dehiscence, decreased in some studies, and was inconsistent to make a conclusion. Because of limited studies, it is difficult to make any assertions on the other variables, suggesting a requirement for further studies for proper recommendations on INPWT.
C1 [Scalise, Alessandro; Calamita, Roberto; Tartaglione, Caterina; Pierangeli, Marina; Bolletta, Elisa; Gioacchini, Matteo; Di Benedetto, Giovanni] Univ Politecn Marche, Dept Plast & Reconstruct Surg, Via Conca 71, I-60126 Ancona, Italy.
   [Gesuita, Rosaria] Univ Politecn Marche, Interdept Ctr Epidemiol Biostat & Med Informat EB, Ancona, Italy.
C3 Marche Polytechnic University; Marche Polytechnic University
RP Scalise, A (通讯作者)，Univ Politecn Marche, Dept Plast & Reconstruct Surg, Via Conca 71, I-60126 Ancona, Italy.
EM chiplast@univpm.it
RI ; Gesuita, Rosaria/AAU-8863-2020
OI Scalise, Alessandro/0000-0002-9198-4943; Gesuita,
   Rosaria/0000-0002-6943-0602
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NR 121
TC 186
Z9 197
U1 2
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2016
VL 13
IS 6
BP 1260
EP 1281
DI 10.1111/iwj.12492
PG 22
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8TQ
UT WOS:000387664400024
PM 26424609
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Pauser, J
   Nordmeyer, M
   Biber, R
   Jantsch, J
   Kopschina, C
   Bail, HJ
   Brem, MH
AF Pauser, Johannes
   Nordmeyer, Matthias
   Biber, Roland
   Jantsch, Jonathan
   Kopschina, Carsten
   Bail, Hermann J.
   Brem, Matthias H.
TI Incisional negative pressure wound therapy after hemiarthroplasty for
   femoral neck fractures - reduction of wound complications
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Femoral neck fractures; iNPWT; Negative pressure wound therapy; Wound;
   Wound secretion
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISIONS; MANAGEMENT; SURGERY; HIP;
   MORTALITY; TRAUMA; DEFECT; BONE
AB The aim of the study was to evaluate the use of incisional negative pressure wound therapy (iNPWT) in wound healing after femoral neck fracture (FNF) treated with hip hemiarthroplasty (HA) and its influence on postoperative seromas, wound secretion, as well as time and material consumption for dressing changes. The study is a prospective randomised evaluation of iNPWT in patients with large surgical wounds after FNF. Patients were randomised either to be treated by iNPWT (group A) or a standard wound dressing (group B). Follow-up included ultrasound measurements of seroma volumes on postoperative days 5 and 10, duration of wound secretion, and time and material spent for wound dressing changes. For comparison of the means, we used the t-test for independent samples, P > 0.05 was considered significant. There were 21 patients randomised in this study. Group A (11 patients, 81.6 +/- 5.2 years of age) developed a seroma of 0.257 +/- 0.75 cm(3) after 5 days and had a secretion of 0.9 +/- 1.0 days, and the total time for dressing changes was 14.8 +/- 3.9minutes, whereas group B (ten patients, 82.6 +/- 8.6 years of age) developed a seroma of 3.995 +/- 5.01 cm(3) after 5 days and had a secretion of 4.3 +/- 2.45 days, and the total time for dressing changes was 42.9 +/- 11.0 minutes. All mentioned differences were significant. iNPWT has been used on many different types of traumatic and non-traumatic wounds. This prospective, randomised study has demonstrated decreased development of postoperative seromas, reduction of total wound secretion days and reduction of needed time for dressing changes.
C1 [Pauser, Johannes; Nordmeyer, Matthias; Biber, Roland; Kopschina, Carsten; Bail, Hermann J.; Brem, Matthias H.] Univ Erlangen Nurnberg, Klinikum Nurnberg, Dept Orthopaed & Trauma Surg, Breslauer St 201, D-90471 Nurnberg, Germany.
   [Jantsch, Jonathan] Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Med Microbiol, Erlangen, Germany.
   [Jantsch, Jonathan] Univ Regensburg, Inst Med Microbiol & Hyg, Regensburg, Germany.
C3 Klinikum Nurnberg; University of Erlangen Nuremberg; University of
   Erlangen Nuremberg; University of Regensburg
RP Brem, MH (通讯作者)，Univ Erlangen Nurnberg, Klinikum Nurnberg, Dept Orthopaed & Trauma Surg, Breslauer St 201, D-90471 Nurnberg, Germany.
EM matthiasbrem@hotmail.de
RI Jantsch, Jonathan/KEE-9741-2024; Biber, Roland/AAP-6691-2021
OI Biber, Roland/0000-0002-7700-0311
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NR 27
TC 48
Z9 52
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 663
EP 667
DI 10.1111/iwj.12344
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600062
PM 25125244
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Ozkan, OF
   Koksal, N
   Altinli, E
   Celik, A
   Uzun, MA
   Cikman, O
   Akbas, A
   Ergun, E
   Kiraz, HA
   Karaayvaz, M
AF Ozkan, Omer F.
   Koksal, Neset
   Altinli, Ediz
   Celik, Atilla
   Uzun, Mehmet A.
   Cikman, Oztekin
   Akbas, Alpaslan
   Ergun, Ersin
   Kiraz, Hasan A.
   Karaayvaz, Muammer
TI Fournier's gangrene current approaches
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Flexi-Seal Faecal Management System; Fournier's gangrene; Negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; THERAPY
AB Fournier's gangrene is a rare but highlymortal infectious disease characterised by fulminant necrotising fasciitis involving the genital and perineal regions. The objective of this study is to analyse the demographics, clinical feature and treatment approaches as well as outcomes of Fournier's gangrene. Data were collected retrospectively from medical records and operative notes. Patient data were analysed by demographics, aetiological factors, clinical features, treatment approaches and outcomes. Twelve patients (five female and seven male) were enrolled in this study. The most common aetiology was perianal abscess (41.6%). Wound cultures showed a mixture of microorganisms in six (50%) patients. For faecal diversion, while colostomywas performed in six cases (50%), Flexi-Seal was used in two cases (16.6%). In four patients (33.4%), no faecal diversion was performed. Negative pressure wound therapy (NPWT) system was effective in the last four patients (33.4%). The mean hospitalisation period in patients who used NPWT was 18 days, while it was 20 days in the others. NPWT in Fournier's gangrene is a safe dressing method. It promotes granulation formation. Flexi-Seal faecal management is an alternative method to colostomy and provides protection from its associated complications. The combination of two devices (Flexi-Seal and NPWT) is an effective and comfortable method in the management of Fournier's gangrene in appropriate patients.
C1 [Ozkan, Omer F.; Cikman, Oztekin; Karaayvaz, Muammer] Canakkale Onsekiz Mart Univ, Fac Med, Dept Gen Surg, Canakale, Turkey.
   [Koksal, Neset] Kafkas Univ, Dept Gen Surg, Fac Med, Kars, Turkey.
   [Altinli, Ediz] Bilim Univ, Dept Gen Surg, Fac Med, Istanbul, Turkey.
   [Celik, Atilla] Bagcilar Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Uzun, Mehmet A.; Ergun, Ersin] Haydarpasa Numune Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Akbas, Alpaslan] Canakkale Onsekiz Mart Univ, Dept Urol, Fac Med, Canakkale, Turkey.
   [Kiraz, Hasan A.] Canakkale Onsekiz Mart Univ, Dept Anestesiol, Fac Med, Canakkale, Turkey.
C3 Canakkale Onsekiz Mart University; Kafkas University; Demiroglu Bilim
   University; Istanbul Bagcilar Training & Research Hospital; Istanbul
   Haydarpasa Sultan Abdulhamid Training & Research Hospital; Istanbul
   Haydarpasa Numune Training & Research Hospital; Canakkale Onsekiz Mart
   University; Canakkale Onsekiz Mart University
RP Ozkan, OF (通讯作者)，Canakkale 18 Mart Univ, Sch Med, Dept Gen Surg, Kepez, Canakkale, Turkey.
EM ozkanfomer@gmail.com
RI Akbas, Alpaslan/AAX-5617-2020; Uzun, Mehmet/AHD-3410-2022; Celik,
   Atilla/GQA-4443-2022
OI Akbas, Alpaslan/0000-0003-1470-5952; 
CR Altarac S, 2012, UROL INT, V88, P289, DOI 10.1159/000335507
   Arslan E, 2011, INT WOUND J, V8, P224, DOI 10.1111/j.1742-481X.2011.00772.x
   Assenza M, 2011, CLIN TER, V162, pE1
   Cadot P, 2003, J CHIR-PARIS, V140, P22
   Chen SY, 2010, ANN PLAS SURG, V64, P765, DOI 10.1097/SAP.0b013e3181ba5485
   Czymek R, 2009, AM J SURG, V197, P168, DOI 10.1016/j.amjsurg.2008.07.053
   Duchesne JC, 2002, AM SURGEON, V68, P961
   Estrada O, 2009, TECH COLOPROCTOL, V13, P157, DOI 10.1007/s10151-009-0474-6
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   Polo JM, 2008, ACTAS UROL ESP, V32, P1024, DOI 10.1016/S0210-4806(08)73982-2
   Morpurgo E, 2002, SURG CLIN N AM, V82, P1213, DOI 10.1016/S0039-6109(02)00058-0
   Ozkan OF, 2013, INT WOUND J, V6, P1
   Ozturk E, 2009, AM J SURG, V197, P660, DOI 10.1016/j.amjsurg.2008.04.018
   Padmanabhan A, 2007, AM J CRIT CARE, V16, P384
   Pour SM, 2011, J WOUND OSTOMY CONT, V38, P449, DOI 10.1097/WON.0b013e31821e43f1
   Shyam DC, 2013, SURG-J R COLL SURG E, V11, P222, DOI 10.1016/j.surge.2013.02.001
   Vyas Hari Gopal, 2013, Indian J Urol, V29, P161, DOI 10.4103/0970-1591.117255
   Yanar H, 2006, WORLD J SURG, V30, P1750, DOI 10.1007/s00268-005-0777-3
   Yeo ESA, 2010, ANN ACAD MED SINGAP, V39, P806
NR 19
TC 38
Z9 57
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 713
EP 716
DI 10.1111/iwj.12357
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600070
PM 25145578
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU De Caridi, G
   Serra, R
   Massara, M
   Barone, M
   Grande, R
   Butrico, L
   Mastroroberto, P
   de Franciscis, S
   Monaco, F
AF De Caridi, Giovanni
   Serra, Raffaele
   Massara, Mafalda
   Barone, Mario
   Grande, Raffaele
   Butrico, Lucia
   Mastroroberto, Pasquale
   de Franciscis, Stefano
   Monaco, Francesco
TI VAC therapy for the treatment of complex wounds after cardio-thoracic
   surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cardiothoracic surgery; Dehiscence; VAC; Vacuum-assisted closure; Wound
   healing
ID ASSISTED CLOSURE; NEGATIVE-PRESSURE; POSTSTERNOTOMY MEDIASTINITIS;
   EXPERIENCE; MANAGEMENT
AB The aim of this study is to report our experience about the treatment of complex sternal and thoracic wounds following cardiothoracic surgery, using vacuum-assisted closure (VAC therapy. Twelve patients presenting with sternal (five cases) and thoracic (seven cases) wounds that were difficult to heal were treated through VAC therapy after the first surgical debridement. The duration of VAC application ranged from 12 to 36 days with an average hospital stay of 24.6 +/- 11.4 days. During a mean follow-up of 12 months, we observed complete wound healing in seven cases (58.3%), in an average period of 25.5 +/- 14.3 days; one patient died during follow-up, two patients were lost to follow-up and two patients required definitive surgical closure of the wound cavity. In conclusion, VAC therapy promotes faster wound healing, with shorter hospital stay and subsequent lesser in-hospital cost, reducing the mortality rate in the long run. It also promotes early rehabilitation and alleviates the need for a second procedure, thus improving patient satisfaction, with minimal discomfort or inconvenience.
C1 [De Caridi, Giovanni; Massara, Mafalda; Barone, Mario; Monaco, Francesco] Univ Messina, Cardiovasc & Thorac Dept, Policlin G Martino Hosp, Messina, Italy.
   [Serra, Raffaele; Grande, Raffaele; Butrico, Lucia; de Franciscis, Stefano] Magna Graecia Univ Catanzaro, Dept Surg & Med Sci, Catanzaro, Italy.
   [Serra, Raffaele; de Franciscis, Stefano] Magna Graecia Univ Catanzaro, Int Res & Educ Program Clin & Expt Biotechnol, Interuniv Ctr Phlebolymphol CIFL, Catanzaro, Italy.
   [Mastroroberto, Pasquale] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Catanzaro, Italy.
C3 University of Messina; University Messina Policlin; Magna Graecia
   University of Catanzaro; Magna Graecia University of Catanzaro; Magna
   Graecia University of Catanzaro
RP Serra, R (通讯作者)，Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Viale Europa, I-88100 Catanzaro, Italy.
EM rserra@unicz.it
RI De Caridi, Giovanni/KRQ-6363-2024; Serra, Raffaele/AAA-6874-2022;
   Grande, Raffaele/AAO-1388-2020; /AAM-9453-2020
OI De Caridi, Giovanni/0000-0002-1859-9010; Serra,
   Raffaele/0000-0003-4477-7412; de Franciscis,
   Stefano/0000-0001-9365-4609; MONACO, Francesco/0000-0002-5617-7943;
   Barone, Mario/0000-0003-4842-7057; Grande, Raffaele/0000-0003-2873-0104;
   
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 18
TC 8
Z9 11
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 759
EP 762
DI 10.1111/iwj.12369
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600078
PM 25229399
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Bollero, D
   Degano, K
   Gangemi, EN
   Aloj, D
   Malvasio, V
   Stella, M
AF Bollero, Daniele
   Degano, Kiran
   Gangemi, Ezio N.
   Aloj, Domenico
   Malvasio, Valeria
   Stella, Maurizio
TI Long-term follow-up of negative pressure wound therapy with
   instillation: a limb salvage procedure?
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Amputation; Instillation; Limb salvage; Negative pressure; Wound healing
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; QUALITY-OF-LIFE;
   LOWER-EXTREMITY; AMPUTATION; RECONSTRUCTION; INFECTIONS; FRACTURES;
   OUTCOMES; BONE
AB Negative pressure wound therapy (NPWT) is a treatment to reduce oedema, stimulate granulation tissue formation, remove wound exudate and diminish wound area, thus preparing it for secondary healing, skin grafting or coverage with flaps. The association of instillation to NPWT (NPWTi) is a new method for treating severe wounds, in particular, limb lesions at high risk for amputation. This therapy helps to deliver instillation fluid automatically into the contaminated wound, before application of negative pressure. These steps, repeated cyclically, help to remove infectious material, leading to a better moist environment, a necessary condition for wound healing. We report our experience of treating three patients with complex wounds and associated noble structure exposition conservatively with NPWTi and flap coverage. In a long-term follow-up (5 years), we were able to achieve a stable surgery reconstruction on preserved limbs, without evidence of chronic infection and other sequelae or complications. Despite the fact that our experience is limited, as it is based on only a few cases, it suggests how NPWTi could be considered useful in a conservative approach to the treatment of acute complex wounds of the lower extremities. In these patients with high risk of amputation, a long-term follow-up becomes fundamental in order to evaluate wound bed status after NPTWi.
C1 [Bollero, Daniele; Degano, Kiran; Gangemi, Ezio N.; Malvasio, Valeria; Stella, Maurizio] CTO Hosp, AOU Citta Salute, Dept Gen & Specialist Surg, Div Plast & Reconstruct Surg,Burn Ctr, Via Zuretti 29, I-10126 Turin, Italy.
   [Aloj, Domenico] CTO Hosp, AOU Citta Salute, Dept Orthopaed Surg, Div Muscular Skeletal Traumatol, Turin, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino; A.O.U. Citta della
   Salute e della Scienza di Torino
RP Bollero, D (通讯作者)，CTO Hosp, AOU Citta Salute, Dept Gen & Specialist Surg, Div Plast & Reconstruct Surg,Burn Ctr, Via Zuretti 29, I-10126 Turin, Italy.
EM info@danielebollero.it
RI Stella, Maurizio/JGD-2010-2023; Gangemi, Ezio Nicola/M-8754-2019
OI Gangemi, Ezio Nicola/0000-0003-4381-7443
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Boffano M, 2013, CURR ORTHOP PRACT, V24, P557, DOI 10.1097/BCO.0b013e31829e5179
   Bollero D, 2010, Ann Burns Fire Disasters, V23, P43
   Bollero D, 2007, WOUND REPAIR REGEN, V15, P589, DOI 10.1111/j.1524-475X.2007.00267.x
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NR 26
TC 8
Z9 11
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 768
EP 773
DI 10.1111/iwj.12373
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600080
PM 25234266
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Honnegowda, TM
   Kumar, P
   Udupa, EGP
   Sharan, A
   Singh, R
   Prasad, HK
   Rao, P
AF Honnegowda, Thittamaranahalli M.
   Kumar, Pramod
   Udupa, Echalasara G. Padmanabha
   Sharan, Anurag
   Singh, Rekha
   Prasad, Hemanth K.
   Rao, Pragna
TI A comparative study to evaluate the effect of limited access dressing
   (LAD) on burn wound healing
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Antioxidants (GSH, GPx); Burn wound healing; LAD; MDA; Negative
   pressure; Oxidative stress
ID OXIDATIVE ORGAN DAMAGE; LIPID-PEROXIDATION; THERMAL-INJURY;
   NEGATIVE-PRESSURE; FREE-RADICALS; RAT MODEL; PATHOPHYSIOLOGY;
   INFLAMMATION; THERAPY; PROTEIN
AB Biochemical and histopathological analyses are commonly used objective parameters in research and clinical fields to assess the healing status of burn wounds. In this study, the effect of newer intermittent negative-pressure wound therapy in combination with moist environment [limited access dressing (LAD)] on burn wound healing is studied. Various biochemical parameters like hydroxyproline, hexosamine and total protein, and antioxidants like reduced glutathione (GSH), glutathione peroxidase (GPx) and oxidative biomarker malondialdhyde (MDA) were measured in the granulation tissue. Histopathologically, necrotic tissue, amount of inflammatory infiltrate, angiogenesis and extracellular matrix deposition (ECM) were studied to determine wound healing. A total of 55 patients were divided into two groups as follows: LAD group (n=28) and conventional dressing group (n=27). Patients treated with LAD have shown significant increase in the mean levels of (+/- SD) hydroxyproline (75.2 +/- 26.30 versus 27.8 +/- 15.5; P=0.010), hexosamine (9.0 +/- 1.99 versus 8.0 +/- 1.18; P=0.038), total protein (15.6 +/- 8.23 versus 10.26 +/- 4.94; P=0.003), GSH (7.40 +/- 1.91 versus 5.1 +/- 1.28; P=0.037), GPx (112.6 +/- 46.4 versus 92 +/- 32.4; P=0.016), and decrease in MDA (6.5 +/- 2.24 versus 1 0.6 +/- 3.8; P=0.002). Histopathologically, between LAD and conventional dressing groups, there was a significant difference after 10 days of treatment (mean +/- SE) in necrotic tissue of (LAD versus conventional dressing groups=10 +/- 1.8 versus 11.9 +/- 2.6; P=0.033), inflammatory cells (8.4 +/- 1.9 versus 13 +/- 3.46; P=0.021), new blood vessels (12.5 +/- 2.87 versus 9.4 +/- 1.7; P=0.047), ECM deposit (12.9 +/- 2.41 versus 9.68 +/- 1.3; P=0.018) and showed comparatively fewer inflammatory cells, increased and well-organised extracellular matrix deposit, more angiogenesis in LAD group as compared with that in conventional dressing group. To conclude, LAD exerts its beneficial effects on wound healing by reducing oxidative stress, decreasing necrotic tissue and amount of inflammatory infiltrate, and increasing ECM deposition and angiogenesis.
C1 [Honnegowda, Thittamaranahalli M.; Kumar, Pramod; Sharan, Anurag] Kasturba Med Coll & Hosp, Dept Plast Surg & Burns, Manipal, Karnataka, India.
   [Udupa, Echalasara G. Padmanabha; Prasad, Hemanth K.; Rao, Pragna] Kasturba Med Coll & Hosp, Dept Biochem, Manipal, Karnataka, India.
   [Singh, Rekha] Vydehi Inst Med Sci & Res Ctr, Dept Pathol, Bangalore, Karnataka, India.
   [Kumar, Pramod] King Abdul Aziz Specialist Hosp, Sakaka, Al Jouf, Saudi Arabia.
C3 Manipal Academy of Higher Education (MAHE); Kasturba Medical College,
   Manipal; Manipal Academy of Higher Education (MAHE); Kasturba Medical
   College, Manipal
RP Kumar, P (通讯作者)，King Abdul Aziz Hosp, Sakaka, Al Jouf, Saudi Arabia.
EM pkumar86@hotmail.com
RI Kumar, Pramod/L-8280-2015; Rao, Pragna/H-4636-2019
OI Rao, Pragna/0000-0002-1200-889X
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NR 37
TC 6
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 791
EP 798
DI 10.1111/iwj.12384
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600084
PM 25689953
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Sarman, H
   Muezzinoglu, US
   Memisoglu, K
   Baran, T
AF Sarman, Hakan
   Muezzinoglu, Umit S.
   Memisoglu, Kaya
   Baran, Tuncay
TI Vacuum-assisted closure for skin necrosis after revision total knee
   arthroplasty
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Revision total knee arthroplasty; Skin necrosis; Therapy;
   Vacuum-assisted closure
ID WOUND COMPLICATIONS
AB Although skin necrosis following total knee arthroplasty or revision total knee arthroplasty is rare, it may cause severe complications. Skin changes begin with superficial infections and may result in removal of the prosthesis. Treatment of skin necrosis is an important factor, which determines the prognosis of the prosthesis. Several techniques have been defined for sufficient closure. In this article, we present the case of a patient who was treated for skin necrosis that developed after knee revision arthroplasty, using serial debridement, convergence sutures and an intermittent vacuum-assisted closure device (KCI Inc., San Antonio, TX).
C1 [Sarman, Hakan] Abant Izzet Baysal Univ, Dept Orthoped & Traumatol, Bolu, Turkey.
   [Muezzinoglu, Umit S.; Memisoglu, Kaya; Baran, Tuncay] Kocaeli Univ, Dept Orthoped & Traumatol, Kocaeli, Turkey.
C3 Abant Izzet Baysal University; Kocaeli University
RP Sarman, H (通讯作者)，Abant Izzet Baysal Univ, Sch Med, Dept Orthoped & Traumatol, Bolu, Turkey.
EM hakansarman@yahoo.com
RI Sarman, Hakan/B-5281-2015; /AAK-3514-2020
OI Sarman, Hakan/0000-0003-2221-4731; 
CR Ayers DC, 1997, J BONE JOINT SURG AM, V79A, P278, DOI 10.2106/00004623-199702000-00018
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   Ries MD, 2006, CLIN ORTHOP RELAT R, P186, DOI 10.1097/01.blo.0000218723.21720.51
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NR 17
TC 2
Z9 3
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 843
EP 847
DI 10.1111/iwj.12390
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600090
PM 25597628
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Wijewardena, A
   Lajevardi, SS
   Vandervord, E
   Vandervord, J
   Lang, TC
   Fulcher, G
   Jackson, CJ
AF Wijewardena, Aruna
   Lajevardi, Sepehr S.
   Vandervord, Elle
   Vandervord, John
   Lang, Thomas C.
   Fulcher, Gregory
   Jackson, Christopher J.
TI Activated protein C to heal pressure ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Activated protein C; Chronic; Pressure ulcer; Topical negative pressure;
   Wound
ID PREVENTION
AB Pressure ulcers present a major clinical challenge, are physically debilitating and place the patient at risk of serious comorbidities such as septic shock. Recombinant human activated protein C (APC) is an anticoagulant with anti-inflammatory, cytoprotective and angiogenic effects that promote rapid wound healing. Topical negative pressure wound therapy (TNP) has become widely used as a treatment modality in wounds although its efficacy has not been proven through randomised controlled trials. The aim of this study was to determine the preliminary efficacy and safety of treatment with APC for severe chronic pressure sores with and without TNP. This case presentation describes the history, management and outcome of two patients each with a severe chronic non-healing pressure ulcer that had failed to respond to conventional therapy. TNP was added to conservative management of both ulcers with no improvement seen. Then local application of small doses of APC was added to TNP and with conservative management, resulted in significant clinical improvement and rapid healing of both ulcers, displaying rapid growth of vascular granulation tissue with subsequent epithelialisation. Patients tolerated the treatment well and improvements suggested by long-term follow-up were provided. Randomised placebo-controlled double blind trials are needed to quantify the efficacy, safety, cost-effectiveness, optimal dose and quality of life changes seen from treatment with APC.
C1 [Wijewardena, Aruna; Lajevardi, Sepehr S.; Vandervord, Elle; Vandervord, John] Royal North Shore Hosp, Dept Burns & Plast & Reconstruct Surg, St Leonards, NSW, Australia.
   [Lang, Thomas C.; Jackson, Christopher J.] Univ Sydney, Kolling Inst Med Res, Sutton Res Labs, St Leonards, NSW, Australia.
   [Fulcher, Gregory] Univ Sydney, Royal North Shore Hosp, Dept Endocrinol, St Leonards, NSW, Australia.
C3 Royal North Shore Hospital; University of Sydney; Kolling Institute of
   Medical Research; Royal North Shore Hospital; University of Sydney
RP Jackson, CJ (通讯作者)，Univ Sydney, Kolling Inst Med Res, Sutton Res Labs, St Leonards, NSW, Australia.
EM chris.jackson@sydney.edu.au
OI Lang, Thomas/0000-0003-3961-5558; Jackson,
   Christopher/0000-0002-9234-9116
CR [Anonymous], COCHRANE DATABASE SY
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NR 25
TC 13
Z9 13
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 986
EP 991
DI 10.1111/iwj.12343
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600113
PM 25185858
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Asukai, K
   Kashiwazaki, M
   Koizumi, K
   Nobunaga, T
   Yano, H
AF Asukai, Kei
   Kashiwazaki, Masaki
   Koizumi, Kaori
   Nobunaga, Toshikatsu
   Yano, Hiroshi
TI A case report of a 19-week gravid patient with a dehisced abdominal
   wound and treated with VAC ATS® Therapy System
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Dehisced wound; Dehiscence; Gravid; Pregnant; VAC Therapy
ID FIBRIN MATRIX; PROLIFERATION
AB Negative pressure wound therapy (NPWT) is an effective treatment for various non-healing wounds, and V.A.C.(R) Therapy was the first-approved NPWT device by the Japanese government in 2009. We report the case of a 19-week pregnant patient where V.A.C.(R) Therapy was applied to her dehisced laparotomy wound with satisfactory results. The patient was a 30-year-old female who was referred to our hospital from her previous doctor because of the presence of an ovarian cyst on the left ovary. The patient presented at 14weeks into her pregnancy, and surgery was considered because of no reduction in the size of the cyst. An oophorocystectomy was performed, and then the surgical incision was re-opened at postoperative day (POD) 10 due to a surgical site infection. V.A.C.(R) Therapy was initiated on POD 26 (20weeks of pregnancy) and continued for 28 days. After 28 days of V.A.C.(R) Therapy (POD 54), the wound was sutured for complete closure. The foetus did not experience any adverse affects from the surgery and, subsequently, normal vaginal delivery was achieved. This case is the first report of the use of V.A.C.(R) Therapy over a dehisced abdominal wound on a pregnant patient in our country.
C1 [Asukai, Kei; Kashiwazaki, Masaki; Yano, Hiroshi] Hyogo Prefectural Nishinomiya Hosp, Dept Gen Surg, 13-9 Rokutanji Cho, Nishinomiya, Hyogo 6620918, Japan.
   [Koizumi, Kaori; Nobunaga, Toshikatsu] Hyogo Prefectural Nishinomiya Hosp, Dept Obstet & Gynecol, Nishinomiya, Hyogo, Japan.
RP Kashiwazaki, M (通讯作者)，Hyogo Prefectural Nishinomiya Hosp, Dept Gen Surg, 13-9 Rokutanji Cho, Nishinomiya, Hyogo 6620918, Japan.
EM kashiwazaki0707@hp.pref.hyogo.jp
CR Akaishi S, 2007, JPN J SCAR KELOID TR, V1, P63
   Chida H, 2012, JPN MED J IWATE PREF, V52, P32
   Gupta S, 2012, INT WOUND J, V9, pIII, DOI 10.1111/j.1742-481X.2012.00978.x
   Harii K, 2010, Jpn J Plast Surg, V53, P655
   Hunter Judith E, 2007, Int Wound J, V4, P256, DOI 10.1111/j.1742-481X.2007.00361.x
   McNulty AK, 2007, WOUND REPAIR REGEN, V15, P838, DOI 10.1111/j.1524-475X.2007.00287.x
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   Mizuno N, 2011, JPN J CLIN UROL, V65, P153
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NR 12
TC 4
Z9 4
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 992
EP 995
DI 10.1111/iwj.12352
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600114
PM 25209461
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Pieri, M
   Müller, M
   Scandroglio, AM
   Pergantis, P
   Kretzschmar, A
   Kaufmann, F
   Falk, V
   Krabatsch, T
   Arlt, G
   Potapov, E
   Kukucka, M
AF Pieri, Marina
   Mueller, Marcus
   Scandroglio, Anna Mara
   Pergantis, Panagiotis
   Kretzschmar, Alexandra
   Kaufmann, Friedrich
   Falk, Volkmar
   Krabatsch, Thomas
   Arlt, Georg
   Potapov, Evgenij
   Kukucka, Marian
TI Surgical Treatment of Mediastinitis with Omentoplasty in Ventricular
   Assist Device Patients: Report of Referral Center Experience
SO ASAIO JOURNAL
LA English
DT Article
DE mediastinitis; mortality; ventricular assist device; omentoplasty
ID OMENTAL FLAP; IMPLANTATION; INFECTIONS; EXCHANGE; COVERAGE; OUTCOMES
AB Mediastinitis is more frequent in patients with implantable ventricular assist devices (VADs) than in other cardiac surgery patients and carries significant mortality. We report our experience with a stepwise approach including aggressive debridement, jet lavage, vacuum assisted closure dressing, and finally coverage with well-vascularized and immune-active omental flaps in VAD patients with infective mediastinitis. We retrospectively collected and analyzed data of patients with continuous flow VAD who underwent plasty with the omental flap because of mediastinitis at Deutsches Herzzentrum Berlin between January 1, 2008 and October 30, 2015. Eight hundred forty-five patients underwent VAD implantation during the study period. Omentoplasty due to infective mediastinitis was performed in 17 cases. Nine had a HeartWare HVAD as left ventricular assist device (LVAD), three patients had two HeartWare HVAD as biventricular assist device (BIVAD), four had a HeartMate II LVAD device, and one patient had a Berlin Heart Incor LVAD. The microorganisms most frequently isolated from the sternal wound were Gram-positive Staphylococcus spp. Four cases of bleeding requiring surgical revision were recorded: three of intraabdominal and one of wound bleeding. Eight patients (47%) survived, whereas the other nine patients (53%) died. Sixteen (94%) required intensive care unit admission, and median hospital stay was 21 (1-182) days. Postoperative renal failure requiring dialysis and septic shock requiring vasopressors were associated with hospital mortality (p = 0.009 and p = 0.05, respectively). Early surgical treatment of mediastinitis after VAD implantation with omentoplasty is a valuable strategy in an otherwise dead-end situation. Bleeding should be meticulously controlled in these anticoagulated and fragile patients.
C1 [Pieri, Marina; Scandroglio, Anna Mara] IRCCS San Raffaele Sci Inst, Dept Anesthesia & Intens Care, Via Olgettina 60, I-20132 Milan, Italy.
   [Mueller, Marcus; Pergantis, Panagiotis; Kretzschmar, Alexandra; Kaufmann, Friedrich; Falk, Volkmar; Krabatsch, Thomas; Arlt, Georg; Potapov, Evgenij] Deutsch Herzzentrum Berlin, Dept Cardiothorac & Vasc Surg, Berlin, Germany.
   [Falk, Volkmar; Krabatsch, Thomas; Potapov, Evgenij] DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany.
   [Falk, Volkmar] Charite Univ Med Berlin, Dept Cardiothorac Surg, Berlin, Germany.
   [Kukucka, Marian] Deutsch Herzzentrum Berlin, Dept Anesthesiol, Berlin, Germany.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; German
   Heart Center Berlin; German Centre for Cardiovascular Research; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; German Heart Center Berlin
RP Pieri, M (通讯作者)，IRCCS San Raffaele Sci Inst, Dept Anesthesia & Intens Care, Via Olgettina 60, I-20132 Milan, Italy.
EM pieri.marina@hsr.it
RI Kukucka, Marian/Q-2226-2018
OI Kukucka, Marian/0000-0001-6201-1600; Pergantis,
   Panagiotis/0000-0001-9635-2999; Falk, Volkmar/0000-0002-7911-8620
FU Deutsches Herzzentrum Berlin
FX The study was supported by departmental funds of the Deutsches
   Herzzentrum Berlin.
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   Levy DT, 2014, TRANSPL INFECT DIS, V16, P453, DOI 10.1111/tid.12207
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   Turek D, 2009, Rozhl Chir, V88, P693
NR 18
TC 14
Z9 17
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1058-2916
EI 1538-943X
J9 ASAIO J
JI Asaio J.
PD NOV-DEC
PY 2016
VL 62
IS 6
BP 666
EP 670
DI 10.1097/MAT.0000000000000418
PG 5
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA EC1OX
UT WOS:000387876500010
PM 27465093
DA 2026-07-24
ER
PT J
AU Garcia-Ruano, A
   Deleyto, E
   Garcia-Fernandez, S
AF Garcia-Ruano, Angela
   Deleyto, Esther
   Garcia-Fernandez, Sebastian
TI VAC-instillation therapy in abdominal mesh exposure: a novel indication
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Instillation; Mesh; Abdominal; Vacuum
ID PRESSURE WOUND THERAPY; ASSISTED CLOSURE; MANAGEMENT; DEHISCENCE;
   EFFICACY
AB Background: Defects of the abdominal wall pose a problem for general surgeons that negatively affects patient prognosis. In cases of abdominal wall wound dehiscence and exposed abdominal mesh, conservative treatment has not been proven effective to date. We aimed to study patient outcomes in cases of abdominal wall wound dehiscence with mesh exposure treated with vacuum-assisted closure system with intermittent instillation (VAC-instillation) as a temporary cover to achieve wound closure.
   Methods: A retrospective cohort study was performed to evaluate and compare the outcomes of 45 patients with postoperative abdominal wall wound dehiscence and exposed mesh: 34 were treated with conventional dressings and 11 with the VAC-instillation device. Clinical records were reviewed, and patient demographics, indication for abdominal surgery, and existing risk factors were noted. Patient outcome was evaluated in terms of number of reoperations, length of hospital stay, and total time of treatment.
   Results: Demographic features did not differ significantly between the two groups. Patients treated with conventional dressings required a significantly higher number of surgeries to achieve wound closure. We did not find statistical differences between the two groups regarding length of hospital stay, but the VAC-instillation group showed a significantly shorter total time of treatment. The incidence of complications was lower in the VAC-instillation group, though hernia recurrence rate was slightly higher in these patients.
   Conclusions: VAC-instillation is a valid option for the conservative treatment of critical patients with abdominal wall wound dehiscence and exposed infected mesh that allows recovery with fewer surgeries and complications and avoids the need of mesh removal. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Garcia-Ruano, Angela; Deleyto, Esther] Univ Hosp Gregorio Maranon, Dept Plast Aesthet & Reconstruct Surg, Madrid, Spain.
   [Garcia-Fernandez, Sebastian] Univ Hosp Virgen Macarena, Dept Gen Surg, Seville, Spain.
C3 General University Gregorio Maranon Hospital; University of Sevilla;
   Hospital Universitario Virgen Macarena; Virgen del Rocio University
   Hospital
RP Garcia-Ruano, A (通讯作者)，C Gustavo Bacarisas 2,6 B, Seville 41010, Spain.
EM dra.angelagr@gmail.com
OI Deleyto, Esther/0000-0002-8289-2748
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NR 29
TC 15
Z9 17
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD DEC
PY 2016
VL 206
IS 2
BP 292
EP 297
DI 10.1016/j.jss.2016.08.030
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EC2VY
UT WOS:000387983600005
PM 27884322
DA 2026-07-24
ER
PT J
AU Arundel, C
   Buckley, H
   Clarke, E
   Cullum, N
   Dixon, S
   Dumville, J
   Fairhurst, C
   Firth, A
   Henderson, E
   Lamb, K
   McGinnis, E
   Oswald, A
   Goncalves, PS
   Soares, M
   Stubbs, N
   Torgerson, D
   Chetter, I
AF Arundel, Catherine
   Buckley, Hannah
   Clarke, Emma
   Cullum, Nicky
   Dixon, Stephen
   Dumville, Jo
   Fairhurst, Caroline
   Firth, Anna
   Henderson, Eileen
   Lamb, Karen
   McGinnis, Elizabeth
   Oswald, Angela
   Goncalves, Pedro Saramago
   Soares, Marta
   Stubbs, Nikki
   Torgerson, David
   Chetter, Ian
TI Negative pressure wound therapy versus usual care for Surgical Wounds
   Healing by Secondary Intention (SWHSI trial): study protocol for a
   randomised controlled pilot trial
SO TRIALS
LA English
DT Article
DE Surgical wounds; Negative pressure wound therapy; Secondary intention;
   Healing; Randomised controlled trial
AB Background: Most incisions following surgery heal by primary intention, with the edges of the wound apposed with sutures or clips. However, some wounds may break open or be left to heal from the bottom up (i.e. healing by secondary intention). Surgical Wounds Healing by Secondary Intention (SWHSI) are often more complex to manage, and require additional treatments during the course of healing. There is significant uncertainty regarding the best treatment for these complex wounds, with limited robust evidence regarding the clinical and cost-effectiveness of different dressings and treatments; one such treatment is Negative Pressure Wound Therapy (NPWT) which is frequently used in the management of SWHSI. Previous randomised controlled trials (RCTs) of NPWT have failed to recruit to time and target, thus we aimed to conduct a pilot RCT to assess the feasibility of conducting a future, full-scale RCT.
   Methods: This pilot RCT will test the methods and feasibility of recruiting, randomising, and retaining participants into a larger trial of NPWT verses usual care for patients with SWHSI. Participants will be randomised to receive either NPWT or usual care (no NPWT) and will be followed up for 3 months.
   Discussion: This study will provide a full assessment of methods for, and feasibility of, recruiting, randomising, and retaining patients with SWHSI in a trial of NPWT versus usual care. On the basis of this pilot trial, a full trial may be proposed in the future which will provide additional, robust evidence on the clinical and cost-effectiveness of NPWT in the management of SWHSI.
C1 [Arundel, Catherine; Buckley, Hannah; Fairhurst, Caroline; Torgerson, David] Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England.
   [Clarke, Emma; Firth, Anna; Henderson, Eileen; Oswald, Angela; Chetter, Ian] Hull & East Yorkshire Hosp NHS Trust, Kingston Upon Hull, N Humberside, England.
   [Cullum, Nicky; Dumville, Jo] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester, Lancs, England.
   [Dixon, Stephen] Patient & Publ Involvement Grp Representat, Kingston Upon Hull, N Humberside, England.
   [Lamb, Karen; Stubbs, Nikki] Leeds Community Healthcare NHS Trust, Leeds, W Yorkshire, England.
   [McGinnis, Elizabeth] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England.
   [Goncalves, Pedro Saramago; Soares, Marta] Univ York, Ctr Hlth Econ, York, N Yorkshire, England.
   [Chetter, Ian] Hull York Med Sch, York, N Yorkshire, England.
C3 University of York - UK; University of Manchester; University of Leeds;
   University of York - UK; University of York - UK; University of Hull
RP Arundel, C (通讯作者)，Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England.
EM catherine.arundel@york.ac.uk
RI ; Torgerson, David/L-4566-2019; Dumville, Jo/O-7867-2014; Cullum,
   Nicky/F-2438-2011; Soares, Marta Ferreira Oliveira/HJH-3434-2023;
   McGinnis, Elizabeth/PNF-2864-2026; Buckley, Hannah/QAX-3702-2026
OI chetter, ian/0000-0002-2566-6859; McGinnis,
   Elizabeth/0000-0002-2848-9149; Torgerson, David/0000-0002-1667-4275;
   Dumville, Jo/0000-0002-6546-3685; Cullum, Nicky/0000-0003-2631-123X;
   Artrong-Lamb, Karen/0000-0002-4172-4289; Soares, Marta Ferreira
   Oliveira/0000-0003-1579-8513; Arundel, Catherine/0000-0003-0512-4339; 
FU NIHR Programme Grants for Applied Research Programme [RP-PG-0609-10171];
   National Institute for Health Research [RP-PG-0609-10171,
   NF-SI-0512-10028] Funding Source: researchfish; National Institutes of
   Health Research (NIHR) [RP-PG-0609-10171] Funding Source: National
   Institutes of Health Research (NIHR)
FX This project was funded by the NIHR Programme Grants for Applied
   Research Programme (project number RP-PG-0609-10171). The views and
   opinions expressed by authors in this publication are those of the
   authors and do not necessarily reflect those of the NHS, the NIHR, MRC,
   CCF, NETSCC, the Programme Grants for Applied Research Programme or the
   Department of Health.
CR Ashby RL, 2012, TRIALS, V13, DOI 10.1186/1745-6215-13-119
   Brooks R., 2003, MEASUREMENT VALUATIO
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NR 10
TC 12
Z9 16
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD NOV 8
PY 2016
VL 17
AR 535
DI 10.1186/s13063-016-1661-1
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EC5BE
UT WOS:000388147300001
PM 27821142
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Poulakidas, SJ
   Kowal-Vern, A
   Atty, C
AF Poulakidas, Stathis J.
   Kowal-Vern, Areta
   Atty, Corinne
TI Pediatric Frostbite Treated by Negative Pressure Wound Therapy
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID INJURIES; CHILDHOOD; TISSUE
AB Frostbite injury in children can lead to abnormal growth and premature fusion of the epiphyseal cartilage with long-term sequela including, but not limited to, arthroses, deformity, and amputation of the phalanges. This was a retrospective chart review of pediatric frostbite identified in an in-house burn center registry from March 1999 to March 2014. Therapeutic management included negative pressure wound therapy (NPWT). Three patients (age 16-31 months) had frostbitten hands because they were outside in cold weather without gloves. They presented within 24 hours after injury, underwent 5-6 days of NPWT after excision of blisters, and did not lose the distal portion of their digits, or require amputations. On follow-up, all hands were healed well with only minimal or no effect on the growth plate of these pediatric patients. In the early period after frostbite, NPWT may be beneficial in preserving the epiphyseal cartilage in children and preventing long-term complications.
C1 [Poulakidas, Stathis J.] John H Stroger Jr Hosp Cook Cty, Sumner L Koch Burn Ctr, Chicago, IL USA.
   [Poulakidas, Stathis J.; Kowal-Vern, Areta] Rush Univ, Dept Surg, Chicago, IL 60612 USA.
   [Atty, Corinne] Northwestern Univ, Med Ctr, Dept Radiol, Chicago, IL 60611 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; John H Stroger Junior Hospital
   Cook County; Rush University; Northwestern University
RP Kowal-Vern, A (通讯作者)，Rush Univ, Med Ctr, Dept Gen Surg, Div Colorectal Surg, Rush Profess Bldg,Room 1138, Chicago, IL 60612 USA.
EM akvern@comcast.net
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
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   BROWN FE, 1983, PEDIATRICS, V71, P955
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NR 19
TC 6
Z9 6
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD SEP-OCT
PY 2016
VL 37
IS 5
BP E489
EP E492
DI 10.1097/BCR.0000000000000284
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA EC5ZD
UT WOS:000388214900010
PM 26284629
DA 2026-07-24
ER
PT J
AU Babic, S
   Tanaskovic, S
   Lozuk, B
   Samardzic, D
   Popov, P
   Gajin, P
   Matic, P
   Maric, V
   Radak, D
AF Babic, Srdjan
   Tanaskovic, Slobodan
   Lozuk, Branko
   Samardzic, Drazen
   Popov, Petar
   Gajin, Predrag
   Matic, Predrag
   Maric, Vesna
   Radak, Djordje
TI Treatment of stump complications after above-knee amputation using
   negative-pressure wound therapy
SO SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
LA English
DT Article
DE above-knee amputation; wound complication; negative-pressure wound
   therapy (NPWT)
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   WOUNDS; MANAGEMENT; DRESSINGS; SURGERY; DISEASE; SERIES
AB Introduction The stump wound complications after above-knee amputation lead to other problems, such as prolonged rehabilitation, delayed prosthetic restoration, the increase in total treatment cost and high mortality rates.
   Objective To evaluate the safety and outcomes of negative-pressure wound therapy (NPWT) using Vacuum-Assisted Closure (VAC (R)tau psi) therapy in patients with stump complication after above-knee amputation (AKA).
   Methods From January 2011 to July 2014, AKA was performed in 137 patients at the University Cardiovascular Clinic. Nineteen (12.4%) of these patients (mean age 69.3 +/- 9.2 years) were treated with NPWT. The following variables were recorded: wound healing and hospitalization time, rate of NPWT treatment failure, and mortality.
   Results AKA was performed in 17 (89.5%) patients after the vascular or endovascular procedures had been exhausted, while urgent AKA was performed in two (10.5%) patients due to uncontrolled infection. The time before NPWT application was 3.1 +/- 1.9 days and the duration of the NPWT use ranged from 15 to 54 days (mean 27.95 +/- 12.1 days). During NPWT treatment, operative debridement was performed in 12 patients. All the patients were kept on culture-directed intravenous antibiotics. The average hospital length of stay was 34.7 days (range 21-77 days). There were four (20.9%) failures during the treatment which required secondary amputation. During the treatment, one (5.3%) patient died due to multi-organ failure after 27 days.
   Conclusions The use of NPWT therapy in the treatment of AKA stump complication is a safe and effective procedure associated with low risk and positive outcome in terms of wound healing time and further complications.
C1 [Babic, Srdjan; Tanaskovic, Slobodan; Lozuk, Branko; Samardzic, Drazen; Popov, Petar; Gajin, Predrag; Matic, Predrag; Radak, Djordje] Inst Cardiovasc Dis Dedinje, Heroja Milana Tep 1, Belgrade 11000, Serbia.
   [Popov, Petar; Gajin, Predrag; Matic, Predrag; Radak, Djordje] Univ Belgrade, Sch Med, Belgrade, Serbia.
   [Maric, Vesna] Clin Ctr Serbia, Clin Eye Dis, Belgrade, Serbia.
   [Radak, Djordje] Serbian Acad Arts & Sci, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade; Serbian Academy of
   Sciences & Arts
RP Babic, S (通讯作者)，Inst Cardiovasc Dis Dedinje, Heroja Milana Tep 1, Belgrade 11000, Serbia.
EM sdrbabic@sezampro.rs
RI ; Matic, Preag/F-7519-2013
OI Tanaskovic, Slobodan/0000-0003-4216-6693; Matic,
   Preag/0000-0002-9043-347X; Maric, Vesna/0000-0003-3109-0531; Lozuk,
   Branko/0000-0002-7158-2381; Babic, Srdjan/0000-0001-9659-9190
CR [Anonymous], 2004, THER CLIN GUID REF S
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NR 20
TC 3
Z9 3
U1 0
U2 8
PU SRPSKO LEKARSKO DRUSTVO
PI BEOGRAD
PA UREDNISTVO CASOPISA SRPSKI ARHIV, UL DZORDZA VASINGTONA 19, BEOGRAD,
   11000, SERBIA
SN 0370-8179
J9 SRP ARK CELOK LEK
JI Srp. Ark. Celok. Lek.
PD SEP-OCT
PY 2016
VL 144
IS 9-10
BP 503
EP 506
DI 10.2298/SARH1610503B
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EC7FQ
UT WOS:000388302400007
PM 29652466
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tian, B
   Iyer, NG
   Tan, HK
   Tay, AC
   Soo, KC
   Tan, NC
AF Tian, Brian
   Iyer, N. Gopalakrishna
   Tan, Hiang Khoon
   Tay, Ai Choo
   Soo, Khee Chee
   Ngian Chye Tan
TI Novel technique of creating a seal for the vacuum-assisted closure
   system application in complex head and neck wounds
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Article
DE novel; flap; breakdown; fistula; vacuum-assisted closure (VAC)
ID PHARYNGOCUTANEOUS FISTULA; RECONSTRUCTION; MANAGEMENT; THERAPY
AB Background. Achieving a good seal for the application of the vacuum-assisted closure (VAC) system in complex head and neck wounds is difficult.
   Methods. A case series of 4 patients who developed postoperative orocutaneous or pharyngocutaneous fistulas were studied. A sterile green glove was used as a sealant together with the VAC system.
   Results. With utilization of a green glove, a good seal for the VAC system was obtained. This gave ample time to cleanse the wound and allow granulation tissue to form before proceeding on to the next stage of treatment.
   Conclusion. A green glove technique allows for a good seal for the VAC system to work, especially when applied to complex head and neck wounds. (C) 2016 Wiley Periodicals, Inc.
C1 [Tian, Brian; Iyer, N. Gopalakrishna; Tan, Hiang Khoon; Soo, Khee Chee; Ngian Chye Tan] Natl Canc Ctr Singapore, Div Surg Oncol, 11 Hosp Dr, Singapore 169610, Singapore.
   [Tay, Ai Choo] Singapore Gen Hosp, Dept Nursing, Singapore, Singapore.
C3 National Cancer Centre Singapore (NCCS); Singapore General Hospital
RP Tan, NC (通讯作者)，Natl Canc Ctr Singapore, Div Surg Oncol, 11 Hosp Dr, Singapore 169610, Singapore.
EM tan.ngian.chye@nccs.com.sg
RI Tan, Hiang Khoon/AAG-2815-2021
OI Tan, Hiang Khoon/0000-0002-8565-2926
CR Andrews BT, 2008, ANN OTO RHINOL LARYN, V117, P298, DOI 10.1177/000348940811700410
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NR 11
TC 12
Z9 12
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD DEC
PY 2016
VL 38
IS 12
BP E2523
EP E2526
DI 10.1002/hed.24563
PG 4
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA EC8CI
UT WOS:000388367400002
PM 27534613
DA 2026-07-24
ER
PT J
AU Jhamb, S
   Vangaveti, VN
   Malabu, UH
AF Jhamb, Shaurya
   Vangaveti, Venkat N.
   Malabu, Usman H.
TI Genetic and molecular basis of diabetic foot ulcers: Clinical review
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Review
DE Diabetic foot ulcer; Wound; Genetic and molecular aspects
ID PRESSURE WOUND THERAPY; TRANSGENERATIONAL EPIGENETIC INHERITANCE;
   ENDOTHELIAL GROWTH-FACTOR; SHOCK-WAVE THERAPY; METABOLIC MEMORY;
   RECEPTOR 2; COMPLICATIONS; ANGIOGENESIS; EXPRESSION; DISEASE
AB Diabetic Foot Ulcers (DFUs) are major complications associated with diabetes and often correlate with peripheral neuropathy, trauma and peripheral vascular disease. It is necessary to understand the molecular and genetic basis of diabetic foot ulcers in order to tailor patient centred care towards particular patient groups. This review aimed to evaluate whether current literature was indicative of an underlying molecular and genetic basis for DFUs and to discuss clinical applications. From a molecular perspective, wound healing is a process that transpires following breach of the skin barrier and is usually mediated by growth factors and cytokines released by specialised cells activated by the immune response, including fibroblasts, endothelial cells, phagocytes, platelets and keratinocytes. Growth factors and cytokines are fundamental in the organisation of the molecular processes involved in making cutaneous wound healing possible. There is a significant role for single nucleotide polymorphism (SNPs) in the fluctuation of these growth factors and cytokines in DFUs. Furthermore, recent evidence suggests a key role for epigenetic mechanisms such as DNA methylation from long standing hyperglycemia and non-coding RNAs in the complex interplay between genes and the environment. Genetic factors and ethnicity can also play a significant role in the development of diabetic neuropathy leading to DFUs. Clinically, interventions which have improved outcomes for people with DFUs or those at risk of DFUs include some systemic therapeutic drug interventions which improve microvascular blood flow, surgical interventions, human growth factors, and hyperbaric oxygen therapy, negative pressure wound therapy, skin replacement or shockwave therapy and the use of topical treatments. Future treatment modalities including stem cell and gene therapies are promising in the therapeutic approach to prevent the progression of chronic diabetic complications. (C) 2016 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.
C1 [Jhamb, Shaurya; Vangaveti, Venkat N.; Malabu, Usman H.] James Cook Univ, Coll Med & Dent, TREAD, 100 Angus Smith Dr, Douglas, Qld 4814, Australia.
C3 James Cook University
RP Malabu, UH (通讯作者)，James Cook Univ, Coll Med & Dent, TREAD, 100 Angus Smith Dr, Douglas, Qld 4814, Australia.; Malabu, UH (通讯作者)，Townsville Hosp, 100 Angus Smith Dr, Douglas, Qld 4814, Australia.
EM usman.malabu@jcu.edu.au
RI Malabu, Usman Hammawa/K-2055-2013
OI Malabu, Usman Hammawa/0000-0003-4899-7228
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NR 99
TC 86
Z9 111
U1 2
U2 62
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-206X
J9 J TISSUE VIABILITY
JI J. Viab.
PD NOV
PY 2016
VL 25
IS 4
BP 229
EP 236
DI 10.1016/j.jtv.2016.06.005
PG 8
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA ED0QL
UT WOS:000388546900008
PM 27372176
DA 2026-07-24
ER
PT J
AU Gregg, D
   Hiller, L
   Fabri, P
AF Gregg, Desiree
   Hiller, Lynn
   Fabri, Peter
TI The Need to Feed: Balancing Protein Need in a Critically Ill Patient
   With Fournier's Gangrene
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Article
DE necrotizing fasciitis; soft tissue injuries; Fournier gangrene; negative
   pressure wound therapy; acute kidney injury; wound exudate; protein;
   nitrogen balance
ID SOFT-TISSUE INFECTIONS; ACUTE-RENAL-FAILURE; NUTRITION SUPPORT; NITROGEN
   APPEARANCE; GUIDELINES
AB Necrotizing soft tissue injury (NSTI) is rare with an impressively difficult and dangerous clinical course. While the importance of nutrition as part of the treatment plan for NSTI is recognized as essential to recovery, specific recommendations have not been elucidated. A review of the evidence-based guidelines and published research to accomplish wound healing is presented. The nutrition considerations in the setting of organ failure are also discussed. This article outlines a complicated case of a septic, malnourished man with Fournier's gangrene and acute kidney injury. Protein loss from exudate extracted from a negative-pressure vacuum helped estimate the amount of protein needed to accomplish wound healing and guide clinical care. Development of acute kidney injury resulted in protein restriction at the request of the consulting renal service. This restriction led to insufficient protein intake to meet needs required for wound healing as evidenced by a nitrogen balance study and analysis of wound exudate. The estimated daily protein losses through the wound were within 11-26 g protein (2-4 g nitrogen) per day. Inclusion of wound exudate nitrogen loss in nitrogen balance analyses helped resolve conflicting treatment approaches. Estimating protein loss from wound exudate allows for individualization of protein requirements.
C1 [Gregg, Desiree; Hiller, Lynn; Fabri, Peter] James A Haley Vet Hosp, Tampa, FL 33612 USA.
   [Gregg, Desiree] St Josephs Hosp, Tampa, FL USA.
   [Fabri, Peter] Univ S Florida, Tampa, FL USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   James A. Haley Veterans Hospital; State University System of Florida;
   University of South Florida
RP Gregg, D (通讯作者)，James A Haley Vet Hosp, St Josephs Hosp, 3001 W Dr Martin Luther King Jr Blvd, Tampa, FL 33607 USA.
EM dngregg@gmail.com
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NR 27
TC 0
Z9 0
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD DEC
PY 2016
VL 31
IS 6
BP 790
EP 794
DI 10.1177/0884533616651296
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ED2IS
UT WOS:000388667800012
PM 27296812
DA 2026-07-24
ER
PT J
AU Sun, DH
   Ju, WN
   Wang, TJ
   Yu, TC
   Qi, BC
AF Sun, Dahui
   Ju, Weina
   Wang, Tiejun
   Yu, Tiecheng
   Qi, Baochang
TI Vacuum sealing drainage therapy in the presence of an external fixation
   device A case report
SO MEDICINE
LA English
DT Article
DE air leakage; external fixation device; rubber strip; vacuum sealing
   drainage (VSD)
ID ASSISTED CLOSURE; WOUND CONTROL; PRESSURE
AB Rationale: Vacuum sealing drainage (VSD) is widely utilized for treating traumatic wounds.
   Patient concerns: It is particularly difficult and time consuming to use in combination with an external fixator.
   Diagnoses: This is because the hardware or pins used for fixation interfere with maintaining a seal, resulting in poor adhesion and subsequent air leakage.
   Interventions: To resolve this problem, we have devised a new method for sealing the wound dressing, while maintaining the required vacuum. When using this technique, a rubber strip is wrapped around each pin in 3 circles outside the plastic drape, and then tightly tied.
   Outcomes: After completing this procedure, a vacuum is obtained, and any air leakage stops. We employed this technique to treat a cohort of patients in our department over a period of two years, and obtained good healing of soft tissue without air leakage, as well as good clinical outcomes.
   Lessons: We have observed that patients treated with this method experienced good clinical outcomes without air leakage, and we recommend its use in treating cases where an external fixation device is present.
C1 [Sun, Dahui; Wang, Tiejun; Yu, Tiecheng; Qi, Baochang] Jilin Univ, Hosp 1, Div Orthoped Traumatol, Changchun, Peoples R China.
   [Ju, Weina] Jilin Univ, Hosp 1, Dept Neurol, Changchun, Peoples R China.
C3 Jilin University; Jilin University
RP Qi, BC (通讯作者)，Jilin Univ, Hosp 1, Div Orthoped Traumatol, Changchun, Peoples R China.
EM qibaochang1@163.com
FU Academy & Research Foundation for Young Scientists [MJR20160015];
   National Natural Science Foundation of China [81500911]; AOTrauma Asia
   Pacific [AOTAP15-01]
FX This project was supported by grants from the Academy & Research
   Foundation for Young Scientists (No. MJR20160015) and the National
   Natural Science Foundation of China (No. 81500911), and also by AOTrauma
   Asia Pacific (Ref: AOTAP15-01).
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NR 9
TC 5
Z9 7
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2016
VL 95
IS 46
AR e5444
DI 10.1097/MD.0000000000005444
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ED3DV
UT WOS:000388730500064
PM 27861393
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kraemer, BA
   Geiger, SE
   Deigni, OA
   Watson, JT
AF Kraemer, Bruce A.
   Geiger, Scott E.
   Deigni, Oliver A.
   Watson, John Tracy
TI Management of Open Lower Extremity Wounds With Concomitant Fracture
   Using a Porcine Urinary Bladder Matrix
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE open leg wounds; extracellular matrix; wound healing; open leg
   fractures; exposed orthopedic hardware
ID OPEN TIBIAL FRACTURES; EXTRACELLULAR-MATRIX; RECONSTRUCTION; SCAFFOLDS;
   CLOSURE; DEGRADATION; COVERAGE; DEFECTS
AB Background. Open wounds of the distal third of the leg and foot with exposed bone, fractures, and hardware are challenging wounds for which to achieve stable coverage. The orthopedic advances in lower extremity fracture management over the last 30 years have allowed a rethinking of the standard operative approach to close these complex wounds. Materials and Methods. The ability of extra cellular matrix (ECM) products to facilitate constructive remodeling of a wound seemed a reasonable approach for treatment, especially in patients who are often poor surgical candidates for more advanced reconstructive procedures. Results. The authors reviewed 9 patients with 11 open fractures of the leg, ankle, or foot treated with a newer ECM wound healing device to total closure. The clinical course and patient management are reviewed. Conclusion. The authors conclude that newer ECM products can provide a reasonable method of management for patients who have wounds with exposed hardware, distal leg wounds, and open foot fractures compared to prolonged negative pressure wound therapy or complex reconstructive operative procedures.
C1 [Kraemer, Bruce A.; Geiger, Scott E.; Deigni, Oliver A.] St Louis Univ, Sch Med, Div Plast & Reconstruct Surg, St Louis, MO USA.
   [Watson, John Tracy] St Louis Univ, Sch Med, Dept Orthoped Surg, St Louis, MO USA.
C3 Saint Louis University; Saint Louis University
RP Kraemer, BA (通讯作者)，St Louis Univ, Sch Med, Div Plast & Reconstruct Surg, 3635 Vista Ave,3rd Floor Desloge Towers, St Louis, MO 63110 USA.
EM kraemerb@slu.edu
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NR 16
TC 13
Z9 15
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2016
VL 28
IS 11
BP 387
EP 394
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ED7DL
UT WOS:000389015800004
PM 27861131
DA 2026-07-24
ER
PT J
AU Aydogdu, O
   Tuncel, U
   Gümüs, M
   Kurt, A
   Oztürk, N
   Aksakal, IA
   Güzel, N
   Çelik, UR
   Erkorkmaz, U
AF Aydogdu, Oguzhan
   Tuncel, Umut
   Gumus, Murat
   Kurt, Alper
   Ozturk, Nuray
   Aksakal, Ibrahim Alper
   Guzel, Nizamettin
   Celik, Ugur Recep
   Erkorkmaz, Unal
TI Zinc-coated Foam With Negative Pressure Wound Therapy in the Treatment
   of Challenging Wounds: A New Alternative Interface Material
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE zinc; interface material; wounds; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; ISCHEMIA-REPERFUSION; CLINICAL-EVALUATION; SKIN
   WOUNDS; IN-VIVO; OXIDE; INJURY; DEVICE; TISSUE; RATS
AB Objective. The aim of the study was to present the authors' clinical observations on zinc-coated foam with negative pressure wound therapy (NPWT). MaterialS and Methods. Ninety-four consecutive patients treated with zinc-coated foam with VAC therapy were retrospectively reviewed. Nonhealing wounds of at least 6 months duration with high to moderate exudate that required open wound management to secondary intervention were included in this study. The evaluation criteria consisted of the measurement of wound surface area, length Of overall treatment time, and a clinical observation of granulation tissue formation in the wound bed. Results. In all wounds, there was a significant decrease of the wound surface area, and wound exudate was obtained at the end Of the treatment. There was a statistically significant difference between pretreatment and posttreatment measurements (P < 0.05). In all wounds, granulation tissue formation was clinically observed by day 6. Of the 94 wounds, 72 were surgically closed and 22 healed secondarily. The follow-up period averaged 12 months, and it was uneventful with no sign of complications from the use of the material. Conclusion. The results of the retrospective study demonstrate zinc-coatedfoam with NPWT can be safely used as an effective and alternative interface material in the treatment of challenging wounds.
C1 [Aydogdu, Oguzhan; Tuncel, Umut; Gumus, Murat; Ozturk, Nuray; Aksakal, Ibrahim Alper; Guzel, Nizamettin] Samsun Educ & Res Hosp, Dept Plast Reconstruct & Aesthet Surg, TR-55100 Samsun, Turkey.
   [Kurt, Alper] Samsun State Hosp, Dept Plast Reconstruct & Aesthet Surg, Samsun, Turkey.
   [Celik, Ugur Recep] Tokat State Hosp, Dept Plast Reconstruct & Aesthet Surg, Tokat, Turkey.
   [Erkorkmaz, Unal] Sakarya Univ, Fac Med, Dept Biostat, Sakarya, Turkey.
C3 Samsun Training & Research Hospital; Samsun Gazi State Hospital; Tokat
   State Hospital; Sakarya University
RP Tuncel, U (通讯作者)，Samsun Educ & Res Hosp, Dept Plast Reconstruct & Aesthet Surg, TR-55100 Samsun, Turkey.
EM drumuttuncel@gmail.com
RI Erkorkmaz, Ünal/AAA-4241-2022; Aksakal, İbrahim Alper/F-5211-2015;
   /AAA-9449-2020; TUNCEL, Umut/P-3185-2015
OI Erkorkmaz, Ünal/0000-0002-8497-4704; 
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NR 46
TC 0
Z9 0
U1 0
U2 12
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2016
VL 28
IS 11
BP 395
EP 403
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ED7DL
UT WOS:000389015800005
PM 27589360
DA 2026-07-24
ER
PT J
AU Ciliberti, M
   De Lara, F
   Serra, G
   Tafuro, F
   Iazzetta, FM
   Filosa, A
   Scognamiglio, R
   Ciliberti, G
   Veneri, MR
AF Ciliberti, Marino
   De lara, Francesco
   Serra, Gianfranco
   Tafuro, Felice
   Iazzetta, Francesco Maria
   Filosa, Alessia
   Scognamiglio, Rosa
   Ciliberti, Giorgia
   Veneri, Maria Rosaria
TI The Effect of a Bacteria- and Fungi-binding Mesh Dressing on the
   Bacterial Load of Pressure Ulcers Treated With Negative Pressure Wound
   Therapy: A Pilot Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE pressure ulcers; negative pressure wound therapy; bacterial load;
   critical colonization; wound infection; bacteria- and fungi-binding mesh
   dressing
ID INFECTION
AB Objective. This study was designed to clinically evaluate the efficacy of a bacteria- and-fungi-binding mesh (BFBM) dressing to modify the bacterial load of pressure ulcers (PUs) of categories 3 Land 4, when used as a wound contact layer (WCL) during negative pressure wound therapy (NPWT). Methods. This was an observational single-centre study in patients with PUs of categories 3 or 4, who were treated with NPWT. Patients were observed for 7 days and received NPWT at -80 mm Hg with the BFBM dressing as the WCL. Wound biopsies were performed at Inclusion (130), at 48 hours (B1), and at day 7 (B7). Bacteria- and fungi-binding mesh dressings were examined for bacterial load at 48 hours (D1) and at 7 days (D7). The primary endpoint was the changes in bacterial loads. Results, Fifty patients were enrolled; 43 (86%) of their PUs were on the sacrum. At B0, 3 groups of wounds were identified by the bioburden level: group A had negative results (28%) to bacterial loads from 10(2) to 5 x 10(3) colony forming units (CFO) CFU/mL (18%); group B had 10(4) to 10(5) CFU/mL (18%); and group C with >= 106 CFU/ML (36%). The authors did not find any significant difference in bacterial loads in group A, but significant differences were found in group B at B1 and B7 (P = 0.04 and P = 0.0067) and in group C at B1 and B7 (P < 0.00001). There was no significant difference on the bacterial loads of the dressing at D1 and D7 (P=0.823). No device-related adverse events were reported. Conclusion. The BFBM dressing seems to be at the origin of a statistically significant reduction of bacterial burden in wounds with moderate or high levels of colonization. The authors' findings suggest BFBM dressings may be a WCL of choice during the treatment of chronic wounds with NPWT.
C1 [Ciliberti, Marino; De lara, Francesco; Serra, Gianfranco; Tafuro, Felice; Iazzetta, Francesco Maria] ASL NAPOLI 3 SUD, Ctr Aziendale Riparaz Tissutale, Naples, Italy.
   [Filosa, Alessia; Scognamiglio, Rosa; Ciliberti, Giorgia; Veneri, Maria Rosaria] ASL NAPOLI 3 SUD, San Leonardo Hosp, Micobiol Unit, Naples, Italy.
RP Ciliberti, M (通讯作者)，ASL NAPOLI 3 SUD, Tissue Repair Ctr, Ctr Aziendale Riparaz Tissutale, Via Fusco 12, I-80058 Naples, Italy.
EM marinodoct@gmail.com
CR [Anonymous], 2009, TREATM PRESS ULC QUI
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NR 29
TC 11
Z9 11
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2016
VL 28
IS 11
BP 408
EP 420
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ED7DL
UT WOS:000389015800007
PM 27589361
DA 2026-07-24
ER
PT J
AU Trost, JG
   Lin, LO
   Clark, SJ
   Khechoyan, DY
   Hollier, LH
   Buchanan, EP
AF Trost, Jeffrey G., Jr.
   Lin, Lawrence O.
   Clark, Sarah Jane
   Khechoyan, David Y.
   Hollier, Larry H., Jr.
   Buchanan, Edward P.
TI Separation of Thoraco-Omphalo-Ischiopagus Conjoined Twins: Surgical
   Planning, Management, and Outcomes
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID EXPERIENCE; EXPANSION
AB Background: Conjoined twins are a rare medical phenomenon that offers a unique challenge for medical professionals. The complex anatomy of conjoined twins dictates their survival and amenability to separation, making each case different in terms of medical management, surgical planning, and patient outcomes. Thoraco-omphalo-ischiopagus twins, joined from the thorax to the pelvis, are one of the rarest orientations recorded in the medical literature, and successful separation of this subset of conjoined twins has not been documented. This report presents a novel case of thoraco-omphalo-ischiopagus tetrapus twins who were successfully separated at 10 months of age. The pre-operative planning, operative details, and postoperative course are discussed as they relate to the reconstructive effort.
   Methods: Three-dimensional medical modeling was pursued early in the planning process and was used to estimate the soft-tissue requirements for reconstruction and to design custom tissue expanders.
   Results: The reconstructive effort required postponement until respiratory status was optimized. Even with elaborate preoperative planning, primary closure of the abdomen was limited because of tissue edema and other less predictable patient factors. Delayed closure of the abdominal wall was made possible with negative-pressure wound therapy and secondary flap advancements.
   Conclusion: Preoperative coordination with necessary vendors, a multidisciplinary surgical effort, and optimal timing of the surgical intervention all contribute to the successful separation and long-term survival of thoraco-omphalo-ischiopagus conjoined twins.
C1 Texas Childrens Hosp, Div Plast Surg, Houston, TX 77030 USA.
   Baylor Coll Med, Michael E Debakey Dept Surg, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College Medical Hospital; Baylor
   College of Medicine
RP Buchanan, EP (通讯作者)，6701 Fannin St,CC 610-00, Houston, TX 77030 USA.
EM ebuchana@bcm.edu
RI ; Buchanan, Edward/K-1598-2019
OI Commander, Sarah/0000-0002-0985-9204; 
CR Tannuri ACA, 2013, CLINICS, V68, P371, DOI 10.6061/clinics/2013(03)OA14
   Bhandari PS, 2009, ANN PLAS SURG, V62, P200, DOI 10.1097/SAP.0b013e31817fe464
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   HUNG WT, 1986, J PEDIATR SURG, V21, P920, DOI 10.1016/S0022-3468(86)80088-4
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   Kaufman MH, 2004, CHILD NERV SYST, V20, P508, DOI 10.1007/s00381-004-0985-4
   McDowell BC, 2003, PLAST RECONSTR SURG, V111, P1998, DOI 10.1097/01.PRS.0000056832.00496.2D
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   ZUKER RM, 1986, J PEDIATR SURG, V21, P1198, DOI 10.1016/0022-3468(86)90039-4
NR 16
TC 13
Z9 14
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2016
VL 138
IS 5
BP 1064
EP 1072
DI 10.1097/PRS.0000000000002660
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ED7HM
UT WOS:000389033400054
PM 27783004
DA 2026-07-24
ER
PT J
AU Suh, HSP
   Hong, JP
AF Suh, Hyun-suk Peter
   Hong, Joon Pio
TI Effects of Incisional Negative-Pressure Wound Therapy on Primary Closed
   Defects after Superficial Circumflex Iliac Artery Perforator Flap
   Harvest: Randomized Controlled Study
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; MEDIASTINITIS; MANAGEMENT
AB Background: Prolonged hematoma or seroma after primary closure is a causative element in wound complications. This study evaluated the effects of negative-pressure wound therapy on primary closed wounds after superficial circumflex iliac artery perforator flap harvest.
   Methods: This study was a prospective, randomized, clinical trial comparing conventional dressing against a single application of negative-pressure wound therapy for 5 days after primary closure. A total of 100 patients who had superficial circumflex iliac artery perforator flap harvest were enrolled.
   Results: There was no statistical difference between the incisional negative-pressure wound therapy and conventional dressing groups in the distribution of risk factors. Significant findings were noted for duration and amount of closed suction drainage: 6.12 +/- 4.99 days (median, 4 days; range, 3 to 8 days) and 100.47 +/- 140.69 cc (median, 42 cc) for wounds treated with conventional dressing versus 3.34 +/- 1.35 days (median, 3 days; range, 2 to 4 days) and 23.28 +/- 18.36 cc (median, 20 cc) for wounds in treatment group (p = 0.0077 and p = 0.0004), respectively. After closure, an increase in skin perfusion were noted on day 5 in the treatment group (p = 0.0223). There was one case of wound dehiscence in the conventional dressing group.
   Conclusion: The incisional negative-pressure wound therapy has a positive effect over primary closed surgical defects by significantly reducing the amount of fluid collected by closed suction drains, allowing earlier removal of drains and enhancing the skin perfusion on the repaired skin.
C1 [Suh, Hyun-suk Peter; Hong, Joon Pio] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Plast & Reconstruct Surg, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Hong, JP (通讯作者)，Univ Ulsan, Coll Med, Dept Plast & Reconstruct Surg, 43 Gil 88 Olympicro, Seoul 138736, South Korea.
EM joonphong@amc.seoul.kr
RI Hong, Joon/AEV-0712-2022; SUH, Hyunsuk/ABE-9911-2020
CR Abboud CS, 2004, ANN THORAC SURG, V77, P676, DOI 10.1016/S0003-4975(03)01523-6
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   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Bovill E, 2008, INT WOUND J, V5, P511, DOI 10.1111/j.1742-481X.2008.00437.x
   Brem MH, 2014, INT WOUND J, V11, P3, DOI 10.1111/iwj.12252
   Ferguson TB, 2000, ANN THORAC SURG, V69, P680, DOI 10.1016/S0003-4975(99)01538-6
   Goldstein JA, 2010, J FOOT ANKLE SURG, V49, P513, DOI 10.1053/j.jfas.2010.07.001
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   Suh H, 2014, ANN PLAST SURG, V76, P117
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NR 32
TC 28
Z9 29
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2016
VL 138
IS 6
BP 1333
EP 1340
DI 10.1097/PRS.0000000000002765
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ED7HQ
UT WOS:000389033800055
PM 27879604
DA 2026-07-24
ER
PT J
AU Galstyan, GR
   Tokmakova, AY
   Zaitseva, EL
   Doronina, LP
   Voronkova, IA
   Molchkov, RV
AF Galstyan, G. R.
   Tokmakova, A. Yu.
   Zaitseva, E. L.
   Doronina, L. P.
   Voronkova, I. A.
   Molchkov, R. V.
TI Comparative evaluation of the intensity of reparative processes in the
   lower extremity soft tissues of diabetic patients receiving local
   negative pressure wound treatment and standard wound care
SO TERAPEVTICHESKII ARKHIV
LA Russian
DT Article
DE diabetes mellitus; chronic wounds; local treatment; negative pressure
   wound therapy; vacuum; repair; immunohistochemistry; histology
ID FOOT ULCERS; THERAPY
AB Aim. To study the intensity of soft tissue repair in patients with diabetic foot syndrome (DFS) during local negative pressure wound treatment versus standard wound care.
   Subjects and methods. The investigators estimated the clinical (wound sizes, local tissue oxygenation), histological (light microscopy), and immunohistochemical (CD31, CD68, MMP-9, and TIMP-1) markers for reparative processes in patients with DFS during vacuum therapy versus standard wound care. Forty-two patients with the neuropathic and neuroischemic (without critical ischemia) forms of DFS were examined after debridement. In the perioperative period, 21 patients received negative pressure wound therapy and 21 had standard wound care.
   Results. During vacuum therapy, the area and depth of wound defects decreased by 19.8 +/- 7.8 and 42.8 +/- 5.6%, respectively (p=0.002) (as compared to the baseline data). In the control group, these indicators were 17.0 +/- 19.4 and 16.6 +/- 21.6% (p=0.002). There was a significant intensification of local microhemodynamics according to transcutaneous oximetry readings in the negative pressure wound treatment group. After 9 2 days of treatment, histological examination of granulation tissue revealed a significant reduction in edema, cessation of inflammatory infiltration, and formation of mature granulation tissue in Group 1. Immunohistological examination indicated a more obvious increase in the count of macrophages (CD68 staining) and a significant increment in the number of newly formed vessels, as evidenced by anti-CD31 antibody staining. During the treatment, there was a decline of the expression of MMP-9 and an increase in that of TIMP-1, as compared to those in the control group.
   Conclusion. The findings are indicative of the enhanced intensity of reparative processes in patients with DFS during vacuum therapy versus standard wound care, resulting in more rapidly decreased wound sizes, increased local microhemodynamics, reduced inflammation, and accelerated wound transition from the inflammatory to the proliferative phase.
C1 [Galstyan, G. R.; Tokmakova, A. Yu.; Zaitseva, E. L.; Doronina, L. P.; Voronkova, I. A.; Molchkov, R. V.] Minist Hlth Russia, Endocrinol Res Ctr, Moscow, Russia.
C3 Ministry of Health of the Russian Federation; Russian Academy of Medical
   Sciences; Endocrinology Research Centre
RP Zaitseva, EL (通讯作者)，Minist Hlth Russia, Endocrinol Res Ctr, Moscow, Russia.
EM zai.kate@gmail.com
RI Tokmakova, Alla/HHR-9409-2022
OI Tokmakova, Alla/0000-0003-2474-9924
CR [Anonymous], 2015, IWGDF GUID DIAB FOOT
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   Stansby G, 2010, J WOUND CARE, V19, P496, DOI 10.12968/jowc.2010.19.11.79706
   2015, ATLAS DIABETA IDF
NR 13
TC 4
Z9 4
U1 0
U2 4
PU IZDATELSTVO MEDITSINA
PI MOSCOW
PA PETROVERIGSKII PER 6-8, K-142 MOSCOW, RUSSIA
SN 0040-3660
EI 2309-5342
J9 TERAPEVT ARKH
JI Ter. Arkhiv
PY 2016
VL 88
IS 10
BP 19
EP 24
DI 10.17116/terarkh2016881019-24
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ED8ZK
UT WOS:000389159400003
PM 27801415
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Van Hecke, LL
   Haspeslagh, M
   Hermans, K
   Martens, AM
AF Van Hecke, Lore L.
   Haspeslagh, Maarten
   Hermans, Katleen
   Martens, Ann M.
TI Comparison of antibacterial effects among three foams used with negative
   pressure wound therapy in an ex vivo equine perfused wound model
SO AMERICAN JOURNAL OF VETERINARY RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EVIDENCE-BASED RECOMMENDATIONS; BACTERIAL LOAD;
   MANAGEMENT; STEPS
AB OBJECTIVE
   To compare antibacterial effects among 3 types of foam used with negative-pressure wound therapy (NPWT) in an ex vivo equine perfused wound model.
   SAMPLES
   Abdominal musculocutaneous flaps from 6 equine cadavers.
   PROCEDURES
   Each musculocutaneous flap was continuously perfused with saline (0.9% NaCl) solution. Four 5-cm circular wounds were created in each flap and contaminated with 10(6) CFUs of both Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA). After a 1-hour incubation period, 1 of 4 treatments (NPWT with silver-impregnated polyurethane foam [NPWT-AgPU], polyurethane foam [NPWT-PU], or polyvinyl alcohol foam [NPWT-PVA] or a nonadherent dressing containing polyhexamethylene biguanide without NPWT [control]) was randomly applied to each wound. An 8-mm punch biopsy specimen was obtained from each wound immediately before and at 6, 12, 18, and 24 hours after treatment application to determine the bacterial load for both P aeruginosa and MRSA.
   RESULTS
   The bacterial load of P aeruginosa for the NPWT-PVA treatment was significantly lower than that for the other 3 treatments at each sampling time after application, whereas the bacterial load for the NPWT-AgPU treatment was significantly lower than that for the NPWT-PU and control treatments at 12 hours after application. The bacterial load of MRSA for the NPWT-PVA treatment was significantly lower than that for the other 3 treatments at each sampling time after application.
   CONCLUSIONS AND CLINICAL RELEVANCE
   Results indicated that wounds treated with NPWT-PVA had the greatest decrease in bacterial load; however, the effect of that treatment on wound healing needs to be assessed in vivo.
C1 [Van Hecke, Lore L.; Haspeslagh, Maarten; Martens, Ann M.] Univ Ghent, Fac Vet Med, Dept Surg & Anaesthesiol Domest Anim, B-9820 Merelbeke, Belgium.
   [Hermans, Katleen] Univ Ghent, Fac Vet Med, Dept Pathol Bacteriol & Poultry Dis, B-9820 Merelbeke, Belgium.
C3 Ghent University; Ghent University
RP Van Hecke, LL (通讯作者)，Univ Ghent, Fac Vet Med, Dept Surg & Anaesthesiol Domest Anim, B-9820 Merelbeke, Belgium.
EM lore.vanhecke@ugent.be
RI Haspeslagh, Maarten/T-8618-2019
OI Haspeslagh, Maarten/0000-0001-6381-590X; Martens,
   Ann/0000-0001-9554-4841
FU Ghent University [01D25512]
FX Supported by the Special Research Fund, Ghent University (grant No.
   01D25512).
CR Antweiler RC, 2008, ENVIRON SCI TECHNOL, V42, P3732, DOI 10.1021/es071301c
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NR 23
TC 15
Z9 16
U1 1
U2 25
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0002-9645
EI 1943-5681
J9 AM J VET RES
JI Am. J. Vet. Res.
PD DEC
PY 2016
VL 77
IS 12
BP 1325
EP 1331
DI 10.2460/ajvr.77.12.1325
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA EE2KF
UT WOS:000389412100003
PM 27901391
DA 2026-07-24
ER
PT J
AU Skinner, OT
   Cuddy, LC
   Coisman, JG
   Covey, JL
   Ellison, GW
AF Skinner, Owen T.
   Cuddy, Laura C.
   Coisman, James G.
   Covey, Jennifer L.
   Ellison, Gary W.
TI Temporary Rectal Stenting for Management of Severe Perineal Wounds in
   Two Dogs
SO JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; NECROTIZING FASCIITIS; FECAL DIVERSION; TRAUMA;
   COLOSTOMY; INJURIES; THERAPY; DISEASE; SYSTEM
AB Perineal wounds in dogs present a challenge due to limited local availability of skin for closure and constant exposure to fecal contaminants. This report describes temporary rectal stenting in two dogs following severe perineal wounds. Dog 1 presented with a 4 3 4 cm full-thickness perineal slough secondary to multiple rectal perforations. A 12 mm internal diameter endotracheal tube was placed per-rectum as a temporary stent to minimize fecal contamination. The stent was removed 18 days after placement, and the perineal wound had healed at 32 days post-stent placement, when a minor rectal stricture associated with mild, intermittent tenesmus was detected. Long-term outcome was deemed good. Dog 2 presented with multiple necrotic wounds with myiasis, circumferentially surrounding the anus and extending along the tail. A 14 mm internal diameter endotracheal tube was placed per-rectum. The perineal and tail wounds were managed with surgical debridement and wet-to-dry and honey dressings prior to caudectomy and negative pressure wound therapy (NPWT). Delayed secondary wound closure and stent removal were performed on day six without complication. Long-term outcome was deemed excellent. Temporary rectal stenting may be a useful technique for fecal diversion to facilitate resolution of complex perineal injuries, including rectal perforation.
C1 [Skinner, Owen T.; Ellison, Gary W.] Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA.
   [Coisman, James G.] Joint Base Lewis McChord Vet Ctr, Tacoma, WA USA.
   [Cuddy, Laura C.] Univ Coll Dublin, Sch Vet Med, Dept Surg, Sect Vet Clin Studies, Dublin, Ireland.
   [Covey, Jennifer L.] Oakland Vet Referral Serv, Bloomfield Hills, NJ USA.
C3 State University System of Florida; University of Florida; University
   College Dublin
RP Skinner, OT (通讯作者)，Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA.
EM skinnero@ufl.edu
RI Skinner, Owen/AAG-9602-2020
OI Skinner, Owen/0000-0002-3765-429X
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NR 24
TC 2
Z9 2
U1 1
U2 12
PU AMER ANIMAL HOSPITAL ASSOC
PI LAKEWOOD
PA PO BOX 150899, LAKEWOOD, CO 80215-0899 USA
SN 0587-2871
EI 1547-3317
J9 J AM ANIM HOSP ASSOC
JI J. Am. Anim. Hosp. Assoc.
PD NOV-DEC
PY 2016
VL 52
IS 6
BP 385
EP 391
DI 10.5326/JAAHA-MS-6350
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA EE2RC
UT WOS:000389430900006
PM 27685361
DA 2026-07-24
ER
PT J
AU Nie, B
   Yue, B
AF Nie, B.
   Yue, B.
TI Biological effects and clinical application of negative pressure wound
   therapy: a review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE negative pressure wound therapy; bacterial growth; growth factor;
   clinical application; novel dressingvacuum
ID VACUUM-ASSISTED CLOSURE; MESENCHYMAL STEM-CELLS; INFECTED WOUNDS;
   INFLAMMATORY RESPONSE; BACTERIAL BIOBURDEN; INSTILL(R) THERAPY;
   INTERNAL-FIXATION; SILVER DRESSINGS; CONTROLLED-TRIAL; GROWTH-FACTOR
AB Negative pressure wound therapy (NPWT) has shown great advantages in the management of a wide range of clinical problems such as wound or chronic wound healing; open wounds with exposed bone, nerve, or tendon; and orthopaedic implants and related infection in the orthopaedics field. Even though it has shown positive efficacy in treating infection (wound infection or orthopaedic implant infection), its molecular mechanisms of action remain unclear and require further exploration. Since NPWT is widely used in the clinical setting, a comprehensive understanding of its biological effect will assist in appropriate clinical application. This review summarises the biological effect of NPWT on bacteria and cell growth as well as the possible mechanisms associated with NPWT applied in wound healing. We also highlight novel antibacterial dressings for NPWT. PubMed, and Web of Science database searches were conducted. Several search terms were used including negative pressure wound therapy, bacterial growth, growth factor, wound healing, dressing. All databases were searched from inception to 2015, references that lacked original resarch were eliminated.
C1 [Nie, B.; Yue, B.] Shanghai Jiao Tong Univ, Sch Med, Shanghai Ninth Peoples Hosp, Dept Orthoped Surg,Shanghai Key Lab Orthoped Impl, Shanghai 200011, Peoples R China.
C3 Shanghai Jiao Tong University
RP Yue, B (通讯作者)，Shanghai Jiao Tong Univ, Sch Med, Shanghai Ninth Peoples Hosp, Dept Orthoped Surg,Shanghai Key Lab Orthoped Impl, Shanghai 200011, Peoples R China.
EM advbmp2@163.com
FU National Natural Science Foundation of China [81472119]
FX This work was supported by the National Natural Science Foundation of
   China (81472119).
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   Yang SL, 2014, WOUND REPAIR REGEN, V22, P548, DOI 10.1111/wrr.12195
   Yang Z, 2014, MOL MED REP, V9, P1331, DOI 10.3892/mmr.2014.1968
   Yang Z, 2009, J ZHEJIANG UNIV-SC B, V10, P188, DOI 10.1631/jzus.B0820240
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NR 101
TC 20
Z9 23
U1 1
U2 26
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2016
VL 25
IS 11
BP 617
EP 625
DI 10.12968/jowc.2016.25.11.617
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EE6GN
UT WOS:000389707600005
PM 27827278
DA 2026-07-24
ER
PT J
AU Ahmed, ME
   Mohammed, MS
   Mahadi, SI
AF Ahmed, M. E.
   Mohammed, M. S.
   Mahadi, S. I.
TI Primary wound closure of diabetic foot ulcers by debridement and
   stitching
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE diabetic foot ulcer; wound closure; stitching
ID THERAPY
AB Objective: The role of stitching in healing diabetic foot ulcers (DFUs) has little attention, with few reports published on the technique. This study aimed to report on the role of stitching in healing of neuropathic DFUs.
   Method: This comparative study was between patients with diabetes with neuropathic foot ulcers who had undergone wound stitching and those on conventional wound care. The study was carried in Jabir Abu Eliz Diabetic Center Khartoum (JADC) during between January 1 2011 and January 1 2013. All patients presented with neuropathic diabetic septic foot on the plantar aspect or extending up the leg were included. Initial surgical sharp debridement under intravenous broad spectrum antibiotics was performed and oral antibiotics were given 3 days later after the results of the bacterial culture were received. Regular wound debridement was performed with the aim of pairing the wound edges for stitching. Primary closure was performed when the wound was clean from any necrotic tissues and partial closure when the wound was still oozy to secure drainage and avoid splaying of the wound edges. All patients were using either crutches or wheel chair initially until any sepsis cleared and then proper off-loading by shoes purpose made in our centre.
   Results: A 160 patients with neuropathic DFUs that needed debridement and frequent dressing changes as outpatients were included. Both groups had the same tap water wound dressing either daily, every other day or every two days according to the wound progress. Absorbent dressings and negative pressure wound therapy (NPWT) were unavailable. Half of the patients (n=80) had debridement, frequent dressing change using tap water throughout the period of study (group 1) while the rest (n=80) in addition to wound debridement underwent stitching of their wounds (group 2). Complete healing was achieved in 46 patients in Group 1 (57.5%) compared with 19 patients (23%) in group 2 (p=0.001). The average number of dressings used was 19 in stitch group compared with 30 in the non-stitch group (p=0.000). The average duration of healing in stitch group was 2.9 months compared with 5.7 months in non-stitch group (p=0.000).
   Conclusion: Stitching of neuropathic DFUs reduced the duration of wound healing and the frequency of wound dressing change.
C1 [Ahmed, M. E.; Mahadi, S. I.] Univ Khartoum, Fac Med, Dept Surg, Khartoum, Sudan.
   [Mohammed, M. S.] Alfred Univ, Alfred, NY 14802 USA.
C3 University of Khartoum; State University of New York (SUNY) System;
   Alfred University
RP Ahmed, ME (通讯作者)，Univ Khartoum, Fac Med, Dept Surg, Khartoum, Sudan.
EM rasheid@usa.net
CR Ahmed ME, 2010, J FOOT ANKLE SURG, V49, P2, DOI 10.1053/j.jfas.2009.07.005
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NR 15
TC 6
Z9 7
U1 0
U2 13
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2016
VL 25
IS 11
BP 650
EP 654
DI 10.12968/jowc.2016.25.11.650
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EE6GN
UT WOS:000389707600009
PM 27827282
DA 2026-07-24
ER
PT J
AU He, R
   Qi, X
   Wen, B
   Li, XY
   Guo, L
AF He, Rui
   Qi, Xin
   Wen, Bing
   Li, XiangYan
   Guo, Li
TI Successful treatment of a rare extended retroperitoneal necrotizing soft
   tissue infection caused by extended-spectrum beta-lactamase-producing
   Escherichia coli A case report
SO MEDICINE
LA English
DT Article
DE ESBL-producing Escherichia coli; necrotizing soft tissue infection;
   retroperitoneal
ID FASCIITIS; MANAGEMENT; DIAGNOSIS; MORTALITY
AB Rationale: Retroperitoneal necrotizing soft tissue infection (NSTI) is a rare but life-threatening disease. Here, we present a case of extended retroperitoneal NSTI caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E coli).
   Patient concerns: The patient complained of progressive redness, swelling, and right flank pain for 10 days, extending to the scrotum for 1 day.
   Diagnoses: He was admitted with an initial diagnosis of cellulitis.
   Interventions: Debridement was performed after the scrotum developed necrosis on day 2 of hospitalization. The source of infection was found to be an idiopathic retroperitoneal abscess, which was confirmed by computed tomography. Two consecutive microbiological cultures (aerobic plus anaerobic) of the tissue revealed the presence of ESBL-producing E coli. With the application of negative pressure wound therapy (NPWT), we sutured the wound after consecutive debridement.
   Outcomes: During the 32 months of follow-up, the patient recovered very well and felt extremely satisfied.
   Lessons: This case reminds us that ESBL-producing E coli can cause retroperitoneal abscesses, which may induce NSTI. Aggressive debridement and broad-spectrum antibiotics should be administrated immediately when NSTI is suspected, and NPWT is an effective adjuvant therapy for wound closure.
C1 [He, Rui; Qi, Xin; Wen, Bing] Peking Univ, Hosp 1, Dept Plast Surg & Burn, Beijing, Peoples R China.
   [Li, XiangYan] Peking Univ, Hosp 1, Dept Antiinfect, Beijing, Peoples R China.
   [Guo, Li] Peking Univ, Hosp 1, Dept Radiol, Beijing, Peoples R China.
C3 Peking University; Peking University; Peking University
RP Qi, X (通讯作者)，Peking Univ, Hosp 1, Dept Plast Surg & Burn, Beijing, Peoples R China.
EM 04983@pkufh.cn
RI Qi, Xin/O-5922-2019; Li, Xiangyan/JDW-4460-2023
OI Qi, Xin/0000-0003-1124-2374; Li, Xiangyan/0000-0001-6780-6314
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NR 20
TC 7
Z9 7
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2016
VL 95
IS 49
AR e5576
DI 10.1097/MD.0000000000005576
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EF0TW
UT WOS:000390040000067
PM 27930570
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gudbjartsson, T
   Jeppsson, A
   Sjögren, J
   Steingrimsson, S
   Geirsson, A
   Friberg, O
   Dunning, J
AF Gudbjartsson, Tomas
   Jeppsson, Anders
   Sjogren, Johan
   Steingrimsson, Steinn
   Geirsson, Arnar
   Friberg, Orjan
   Dunning, Joel
TI Sternal wound infections following open heart surgery - a review
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Review
DE Cardiac surgery; prognosis; risk factors; surgical site infections;
   treatment
ID VACUUM-ASSISTED CLOSURE; TRICLOSAN-COATED SUTURES; SURGICAL SITE
   INFECTION; POST-STERNOTOMY MEDIASTINITIS; DIFFERENT NEGATIVE PRESSURES;
   RANDOMIZED CONTROLLED-TRIAL; GENTAMICIN-COLLAGEN SPONGE;
   CARDIAC-SURGERY; MEDIAN STERNOTOMY; POSTSTERNOTOMY MEDIASTINITIS
AB Surgical site infections (SSIs) are common complications after open heart surgery. Fortunately, most are superficial and respond to minor wound debridement and antibiotics. However, 1-3% of patients develop deep sternal wound infections that can be fatal. Late infections with sternocutaneous fistulas, are encountered less often, but represent a complex surgical problem. This evidence-based review covers etiology, risk factors, prevention and treatment of sternal SSIs following open heart surgery with special focus on advances in treatment, especially negative-pressure wound therapy.
C1 [Gudbjartsson, Tomas; Steingrimsson, Steinn; Geirsson, Arnar] Univ Iceland, Landspitali Univ Hosp, Dept Cardiothorac Surg, Fac Med, Reykjavik, Iceland.
   [Jeppsson, Anders] Sahlgrens Univ Hosp, Dept Cardiothorac Surg, Gothenburg, Sweden.
   [Sjogren, Johan] Skane Univ Hosp, Dept Cardiothorac Surg, Lund, Sweden.
   [Friberg, Orjan] Orebro Univ Hosp, Dept Cardiothorac Surg, Orebro, Sweden.
   [Dunning, Joel] James Cook Univ Hosp, Dept Cardiothorac Surg, Middlesbrough, Cleveland, England.
C3 University of Iceland; Landspitali National University Hospital;
   Sahlgrenska University Hospital; Lund University; Skane University
   Hospital; Orebro University; James Cook University Hospital
RP Gudbjartsson, T (通讯作者)，Univ Iceland, Landspitali Univ Hosp, Dept Cardiothorac Surg, Fac Med, Reykjavik, Iceland.; Gudbjartsson, T (通讯作者)，CONTACT Tomas Gudbjartsson, Reykjavik, Iceland.
EM tomasgud@landspitali.is
RI Sjögren, Johan/AAZ-6448-2021; Friberg, Örjan/AAQ-8685-2020;
   Steingrimsson, Steinn/AAF-5475-2021; Geirsson, Arnar/S-4735-2019
OI Friberg, Örjan/0000-0003-2708-1376; Steingrimsson,
   Steinn/0000-0001-8320-5607; 
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NR 68
TC 41
Z9 46
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2016
VL 50
IS 5-6
BP 341
EP 348
DI 10.1080/14017431.2016.1180427
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EF1SS
UT WOS:000390105700015
PM 27102109
DA 2026-07-24
ER
PT J
AU D'Agostino, D
   Man, A
   Santacroce, L
AF D'Agostino, Donato
   Man, Adrian
   Santacroce, Luigi
TI CURRENT TRENDS IN CARDIAC SURGERY: CLINICAL EXPERIENCE IN THE TREATMENT
   OF MEDIASTINITIS WITH STERNAL WOUND INFECTION THROUGH NEGATIVE PRESSURE
   THERAPY
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Infective complications in cardiac surgery; Mediastinitis; Sternal wound
   infection and/or dehiscence; Negative Pressure Therapy and/or
   Vacuum-Assisted Closure Therapy (VAC Therapy)
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; POSTSTERNOTOMY MEDIASTINITIS;
   FREE-RADICALS; MANAGEMENT; COMPLICATIONS; ENDOCARDITIS; IRRIGATION;
   STERNOTOMY; HEART
AB Introduction: During the last decades, a general amelioration of clinical outcomes has been reported because of the evolution of cardiac surgery techniques. However, infective complications as mediastinitis still represent a major problem in terms of morbidity and mortality in cardiac surgery, with severe suffering of the patient. Furthermore, the incidence of this complication has remained stable over the last three decades and this condition also determines a significant prolongation of hospitalization with an increase in costs. The procedures used for the treatment of mediastinitis have undergone deep modifications over the years but, in despite of these improvements, mortality has remained high. Over the last years, the negative pressure therapy (ie the Vacuum Assisted Closure-Therapy) is taking over all the other treatments.
   Materials and method: From January 2010 to December 2015, at University of Bari Cardiac Surgery Center have been performed 3123 median sternotomy for cardiac surgery. Deep sternal wound infection occurred in 35 patients (1.1207%). In all of these patients was performed vacuum therapy.
   Results: The duration of vacuum treatment was 14.4 +/- 6.7 days. Inflammatory indexes showed a marked decline. At the end of vacuum therapy, in some cases, the reconstruction of the wound was carried out with plastic reconstruction by means of a pectoral flap. No deaths for mediastinitis were recorded, neither any relapse or treatment-related complication. Hospital stay was 30.4 +/- 13.5 days from the beginning of treatment.
   Conclusion: The results obtained in our center with vacuum therapy are much more better than those obtained with classic procedures used in the past. Based on our experience and from analysis of literature, vacuum therapy should be the procedure of choice for the treatment of post-sternotomy mediastinitis. Furthermore, this approach has shown satisfactory results in terms of hospital stay time and costs.
C1 [D'Agostino, Donato] Aldo Moro Univ Bari, Dept Emergency & Organ Transplantat, Sect Cardiac Surg, Bari, Italy.
   [Man, Adrian] Univ Med & Pharm Tirgu Mures, Microbiol, Targu Mures, Romania.
   [Santacroce, Luigi] Aldo Moro Univ Bari, Sch Hlth Profess, Bari, Italy.
   [Santacroce, Luigi] Aldo Moro Univ Bari, Lab Microbiol & Virol, Ionian Dept, DISGEM, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; George Emil Palade University
   of Medicine, Pharmacy, Science, & Technology of Targu Mures; Universita
   degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro
RP D'Agostino, D (通讯作者)，Corso Vittorio Emanuele 143, I-70122 Bari, Italy.
EM d.dagostino@live.it
RI D'AGOSTINO, DONATO/B-1679-2012; Man, Adrian/M-3475-2016; Santacroce,
   Luigi/B-5466-2016
OI D'AGOSTINO, DONATO/0000-0001-5887-7655; Man, Adrian/0000-0001-5281-0601;
   
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NR 40
TC 5
Z9 5
U1 0
U2 2
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2016
VL 32
IS 6
BP 1905
EP 1910
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EF2SJ
UT WOS:000390174300025
DA 2026-07-24
ER
PT J
AU Corona, PS
   Erimeiku, F
   Reverté-Vinaixa, MM
   Soldado, F
   Amat, C
   Carrera, L
AF Corona, Pablo S.
   Erimeiku, Frank
   Mercedes Reverte-Vinaixa, Maria
   Soldado, Francisco
   Amat, Carles
   Carrera, Lluis
TI Necrotising fasciitis of the extremities: implementation of new
   management technologies
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Necrotising fasciitis; Upper extremity; Lower extremity; LRINEC;
   Negative pressure wound therapy; Hydro-bisturi debridement
ID PRESSURE WOUND THERAPY; SOFT-TISSUE INFECTIONS; LABORATORY RISK
   INDICATOR; VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE; HYDROSURGERY
   DEBRIDEMENT; CLINICAL PRESENTATION; SCORING SYSTEMS; LRINEC SCORE;
   DIAGNOSIS
AB Introduction: Necrotising fasciitis (NF) is potentially life-threatening soft-tissue infection. Early diagnosis and aggressive surgical debridement are critical to decrease mortality and morbidity. The impacts of new management technologies such as hydro-bisturi-assisted debridement (HAD) and negative pressure wound therapy (NPWT) are not yet clear with respect to treatment of NF. The objective of this study was to describe laboratory (including LRINEC score), clinical and microbiological factors, treatment methods and outcomes related to managing necrotising fasciitis, focusing on the implementation of new treatment methods in our centre.
   Methods: From June 2010 to June 2014, adult patients diagnosed with necrotising fasciitis affecting an upper or lower limb that were admitted to our hospital, a referral tertiary care centre, were eligible to participate in this study. Demographic data, clinical features, location of infection, Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) score on the day of admission, microbiology and laboratory results, use of HAD, wound management using NPWT, and patient outcomes were retrospectively analysed. A univariate risk factor analysis was performed, in an attempt to define prognostic factors for mortality.
   Results: A total of 20 patients satisfied the inclusion criteria. Type II NF (Group A beta-haemolytic streptococci) was found in 8 cases (40%). The average LRINEC score on the day of admission was 6. The lower extremity was affected in 60% of the cases. All patients were treated operatively, with 2.5 interventions on average. Hydro-bisturi was used in the first debridement in 40% of the cases (8 out 20). In 75% of the studied cases, Negative Pressure Wound Therapy (NPWT) was the technique selected for surgical wound management. The global mortality rate was 30%. On univariate analysis, the only factors significantly associated with mortality were high levels of creatin in (p = 0.033) and low blood glucose levels (p = 0.012). Finally, four amputations were observed in this series.
   Conclusion: We confirm that necrotising fasciitis (NF) of the extremities, despite new advancements in treatment and critical care management, is still a potentially life-threatening soft-tissue infection (30% mortality). New, advanced wound management modalities have been heavily used in management of necrotising fasciitis, but these have not had significant impacts on morbidity and mortality rates. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Corona, Pablo S.; Amat, Carles; Carrera, Lluis] Univ Autonoma Barcelona, Vall Hebron Univ Hosp, Dept Orthopaed Surg, Sept & Reconstruct Surg Unit, Pg Vall Hebron 119-129, Barcelona 08035, Spain.
   [Erimeiku, Frank; Mercedes Reverte-Vinaixa, Maria] Univ Autonoma Barcelona, Vall Hebron Univ Hosp, Dept Orthopaed Surg, Barcelona, Spain.
   [Soldado, Francisco] Hosp St Joan de Deu, Paediat Hand Surg & Microsurg Unit, Barcelona, Spain.
C3 Hospital Universitari Vall d'Hebron; Autonomous University of Barcelona;
   Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron;
   University of Barcelona
RP Corona, PS (通讯作者)，Univ Autonoma Barcelona, Vall Hebron Univ Hosp, Dept Orthopaed Surg, Sept & Reconstruct Surg Unit, Pg Vall Hebron 119-129, Barcelona 08035, Spain.
EM pcorona@vhebron.net
RI Soldado, Francisco Antonio/AAR-3116-2021; Corona, Pablo S/F-7968-2012;
   Amat, Carles/E-9405-2017
OI Soldado, Francisco Antonio/0000-0003-1759-9868; Corona, Pablo
   S/0000-0003-4128-3142; Reverte-Vinaixa, Maria
   Mercedes/0000-0001-9212-7188; Amat, Carles/0000-0002-3057-0595
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NR 41
TC 25
Z9 29
U1 1
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD SEP
PY 2016
VL 47
SU 3
BP S66
EP S71
DI 10.1016/S0020-1383(16)30609-X
PG 6
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA EF7VW
UT WOS:000390538400012
PM 27692110
DA 2026-07-24
ER
PT J
AU Sakai, G
   Suzuki, T
   Hishikawa, T
   Shirai, Y
   Kurozumi, T
   Shindo, M
AF Sakai, G.
   Suzuki, T.
   Hishikawa, T.
   Shirai, Y.
   Kurozumi, T.
   Shindo, M.
TI Primary reattachment of avulsed skin flaps with negative pressure wound
   therapy in degloving injuries of the lower extremity
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Negative-pressure wound therapy; Degloving injury; Skin graft; Lower
   extremity
ID VACUUM-ASSISTED CLOSURE; TECHNICAL REFINEMENT; OPEN FRACTURES;
   MANAGEMENT; GRAFTS; TRIAL; FOOT
AB Large avulsed skin flaps of the lower extremity caused by degloving injuries eventually develop skin necrosis in most cases. The current treatment option involves excision of the degloved skin and reapplication as a full-or split-thickness skin graft. We considered that reattachment of avulsed skin flaps without excision would be theoretically beneficial, since some circulation may remain around the connected pedicle and thus facilitate graft take. Furthermore, securing the skin to the original anatomic position is much easier using retained landmarks. We treated a total of 12 patients (13 cases) with degloving injuries of the lower extremity. In all cases, the avulsed skin flap was defatted and sewn back to the original position, then negative-pressure wound therapy was applied over those grafts as a bolster for approximately 7 days. Most of the avulsed skin flap took excellently, particularly close to the connected pedicle. Nine cases did not need any additional surgical procedures. Four cases required secondary skin graft for a small area of open wound due to partial necrosis of the defatted skin, as well as the raw surface left by the primary skin defect in the initial operation. Primary reattachment of the avulsed skin flaps without excision is convenient and efficient to cover the open wound over the exposed fascia and periosteum in degloving injuries. This would potentially offer a better alternative to definitive wound closure. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Sakai, G.; Suzuki, T.; Hishikawa, T.; Shirai, Y.; Kurozumi, T.; Shindo, M.] Teikyo Univ, Sch Med, Dept Trauma, Tokyo, Japan.
   [Sakai, G.; Suzuki, T.; Hishikawa, T.; Shirai, Y.; Kurozumi, T.; Shindo, M.] Teikyo Univ, Sch Med, Reconstruct Ctr, Tokyo, Japan.
   [Sakai, G.] Nagoya City Univ, Grad Sch Med Sci, Dept Orthoped Surg, Nagoya, Aichi, Japan.
C3 Teikyo University; Teikyo University; Nagoya City University
RP Suzuki, T (通讯作者)，Teikyo Univ, Sch Med, Dept Trauma, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738606, Japan.; Suzuki, T (通讯作者)，Teikyo Univ, Sch Med, Reconstruct Ctr, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738606, Japan.
EM takashisuzuki911@yahoo.co.jp
RI KUROZUMI, TAKETO/AAL-3485-2020
OI KUROZUMI, TAKETO/0000-0003-0270-7993
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NR 27
TC 22
Z9 27
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JAN
PY 2017
VL 48
IS 1
BP 137
EP 141
DI 10.1016/j.injury.2016.10.026
PG 5
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA EF7YF
UT WOS:000390544600024
PM 27788928
DA 2026-07-24
ER
PT J
AU Kantak, NA
   Mistry, R
   Halvorson, EG
AF Kantak, Neelesh A.
   Mistry, Riyam
   Halvorson, Eric G.
TI A review of negative-pressure wound therapy in the management of burn
   wounds
SO BURNS
LA English
DT Review
DE Negative pressure wound therapy; Burns; Skin grafts; Dermal substitutes;
   VAC
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE;
   DONOR SITE; DRESSINGS; TRIAL; PROGRESSION; INTEGRA; SYSTEM; DEVICE
AB Objective: Negative pressure has been employed in various aspects of burn care and the aim of this study was to evaluate the evidence for each of those uses.
   Methods: The PubMed and Cochrane CENTRAL databases were queried for articles in the following areas: negative pressure as a dressing for acute burns, intermediate treatment prior to skin grafting, bolster for skin autografts, dressing for integration of dermal substitutes, dressing for skin graft donor sites, and integrated dressing in large burns.
   Results: Fifteen studies met our inclusion criteria. One study showed negative pressure wound therapy improved perfusion in acute partial-thickness burns, 8 out of 9 studies showed benefits when used as a skin graft bolster dressing, 1 out of 2 studies showed improved rate of revascularization when used over dermal substitutes, and 1 study showed increased rate of re-epithelialization when used over skin graft donor sites.
   Conclusions: Negative pressure can improve autograft take when used as a bolster dressing. There is limited data to suggest that it may also improve the rate of revascularization of dermal substitutes and promote re-epithelialization of skin graft donor sites. Other uses suggested by studies that did not meet our inclusion criteria include improving vascularity in acute partial-thickness burns and as an integrated dressing for the management of large burns. Further studies are warranted for most clinical applications to establish negative pressure as an effective adjunct in burn wound care. (C) 2016 Elsevier Ltd and ISBI. All rights reserved.
C1 [Kantak, Neelesh A.] Harvard Combined Residency Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   [Mistry, Riyam] Univ Bristol, Sch Med, Senate House,Tyndall Ave, Bristol, Avon, England.
   [Halvorson, Eric G.] Brigham & Womens Hosp, Div Plast & Reconstruct Surg, 75 Francis St, Boston, MA 02115 USA.
C3 University of Bristol; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Halvorson, EG (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM ehalvorson@partners.org
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NR 36
TC 35
Z9 50
U1 2
U2 22
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD DEC
PY 2016
VL 42
IS 8
BP 1623
EP 1633
DI 10.1016/j.burns.2016.06.011
PG 11
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA EG5HC
UT WOS:000391073900001
PM 27378361
DA 2026-07-24
ER
PT J
AU Young, CNJ
   Ng, KYB
   Webb, V
   Vidow, S
   Parasuraman, R
   Umranikar, S
AF Young, Christopher N. J.
   Ng, Ka Ying Bonnie
   Webb, Vanessa
   Vidow, Sarah
   Parasuraman, Rajeswari
   Umranikar, Sameer
TI Negative pressure wound therapy aids recovery following surgical
   debridement due to severe bacterial cellulitis with abdominal abscess
   post-cesarean A case report (CARE-Compliant)
SO MEDICINE
LA English
DT Article
DE Cesarean; cellulitis; negative pressure wound therapy (NPWT);
   obstetrics; PICO; RENASYS GO
ID CESAREAN-SECTION
AB Introduction: Bacterial cellulitis post-Cesarean section is rare. Negative pressure wound therapy (NPWT) is widely used in various medical specialities; its effectiveness in obstetrics however remains the topic of debate-used predominantly as an adjunct to secondary intention specific to high-risk patient groups. Its application in the treatment of actively infected wounds post-Cesarean is not well documented. Here, we document NPWT in the treatment of an unusually severe case of bacterial cellulitis with abdominal abscess postpartum. We provide a unique photographic timeline of wound progression following major surgical debridement, documenting the effectiveness of 2 different NPWT systems (RENASYS GO and PICO, Smith & Nephew). We report problems encountered using these NPWT systems and "ad-hoc" solutions to improve efficacy and patient experience.
   A 34-year-old primiparous Caucasian female with no prior history or risk factors for infection and a normal body mass index (BMI) presented with severe abdominal pain, swelling, and extensive abdominal redness 7 days postemergency Cesarean section. Examination revealed extensive cellulitis with associated abdominal abscess. Staphylococcus aureus was identified in wound exudates and extensive surgical debridement undertaken day 11 postnatally due to continued febrile episodes and clinical deterioration, despite aggressive intravenous antibiotic therapy. Occlusive NPWT dressings were applied for a period of 3 weeks before discharge, as well as a further 5 weeks postdischarge into the community.
   NPWT was well tolerated and efficacious in infection clearance and wound healing during bacterial cellulitis. Wound healing averaged 1cm(2) per week before NPWT withdrawal; cessation of NPWT before full wound closure resulted in significantly reduced healing rate, increased purulent discharges, and skin irritation, highlighting the efficacy of NPWT. Five-month follow-up in the clinic found the wound to be fully healed with no additional scarring beyond the boundaries of the original Cesarean incision. The patient was pleased with treatment outcomes, reporting no lasting pain or discomfort from the scar. Conclusions: This report represents the first documented use of NPWT to aid healing of an actively infected, open wound following extensive surgical debridement 10 days post-Cesarean section, confirming both the efficacy and tolerability of NPWT for the treatment of severe bacterial cellulitis in obstetric debridement.
C1 [Young, Christopher N. J.] Univ Portsmouth, Sch Pharm & Biomed Sci, Dept Mol Med, Portsmouth, Hants, England.
   [Ng, Ka Ying Bonnie; Webb, Vanessa; Vidow, Sarah; Parasuraman, Rajeswari; Umranikar, Sameer] Princess Anne Hosp, Dept Obstet & Gynaecol, Southampton, Hants, England.
C3 University of Portsmouth
RP Young, CNJ (通讯作者)，Univ Portsmouth, Sch Pharm & Biomed Sci, Mol Med, St Michaels Bldg, Portsmouth PO1 2DT, Hants, England.
EM christopher.young@port.ac.uk
FU National Institute for Health Research [ACF-2015-26-010] Funding Source:
   researchfish
CR [Anonymous], 2015, COCHRANE DB SYST REV
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NR 17
TC 6
Z9 6
U1 2
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2016
VL 95
IS 50
AR e5397
DI 10.1097/MD.0000000000005397
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EH2SN
UT WOS:000391618400009
PM 27977577
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Youn, HC
   Kwon, SH
AF Youn, Hyo Chul
   Kwon, Se Hwan
TI Endoscopic Vacuum-Assisted Closure (E-VAC) Treatment in a Patient with
   Delayed Anastomotic Perforation following a Perforated Gastric Conduit
   Repair after an Ivor-Lewis Esophagectomy
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE esophageal neoplasm; esophagectomy; anastomotic leakage; endoscopy
ID MANAGEMENT; LEAKAGE
AB It has been reported that intrathoracic esophageal leakages occur at a rate of 4%-17% after Ivor-Lewis esophagectomy. There has been no consensus on a specific treatment for the post-operative anastomotic leakage. Recently, endoscopic vacuum-assisted closure (E-VAC) has been introduced as a novel treatment for the post-operative anastomotic leakage. We herein report the case of a patient with early perforation of the gastric conduit followed by late esophagogastric anastomotic leakage who was successfully treated with early surgical repair and subsequent E-VAC. The patient had been previously diagnosed with achalasia and squamous cell carcinoma of the esophagus and undergone an Ivor-Lewis esophagectomy.
C1 [Youn, Hyo Chul] Kyung Hee Univ Hosp, Dept Thorac & Cardiovasc Surg, Seoul, South Korea.
   [Kwon, Se Hwan] Kyung Hee Univ Hosp, Dept Radiol, Seoul, South Korea.
C3 Kyung Hee University; Kyung Hee University Hospital; Kyung Hee
   University; Kyung Hee University Hospital
RP Youn, HC (通讯作者)，Kyung Hee Univ, Dept Thorac & Cardiovasc Surg, Med Ctr, 130-702 Hoegi Dong, Seoul, South Korea.
EM younhc71@hanmail.net
RI Kwon, Se Hwan/ABF-3209-2020
OI Kwon, Se Hwan/0000-0002-7777-8422
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NR 11
TC 10
Z9 12
U1 0
U2 0
PU MEDICAL TRIBUNE INC
PI TOKYO
PA ED COMM ANNALS THORACIC CARDIOVASCULAR SURG, 2-1-30 KUDAN MINAMI,
   CHIYODA-KU, TOKYO, 102-0074, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2016
VL 22
IS 6
BP 363
EP 366
DI 10.5761/atcs.cr.15-00305
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA EH4QH
UT WOS:000391755200007
PM 27075934
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sugrue, M
AF Sugrue, Michael
TI Abdominal compartment syndrome and the open abdomen: any unresolved
   issues?
SO CURRENT OPINION IN CRITICAL CARE
LA English
DT Review
DE abdominal compartment syndrome; abdominal wall closure; open abdomen
ID DAMAGE-CONTROL LAPAROTOMY; SEVERE ACUTE-PANCREATITIS; INTRAABDOMINAL
   HYPERTENSION; FASCIAL CLOSURE; NONTRAUMA PATIENTS; PRESSURE;
   100-PERCENT; MANAGEMENT
AB Purpose of review
   This article reviews the key principles of abdominal compartment syndrome and the open abdomen, exploring some of the unresolved issues. It reviews new concepts in care.
   Recent findings
   Recent use of peritoneal resuscitation, and benefits of mesh-mediated traction are discussed. Abdominal compartment syndrome remains a result of complex interaction between general haemorrhage, sepsis and fluid resuscitation. Improved resuscitation and sepsis control has decreased but not abolished the need for the open abdomen and progression for abdominal compartment syndrome. Fourth-generation abdominal wall dressings need to be combined with a dynamic closure system; currently, negative pressure wound therapy at the index open abdomen coupled with mesh-mediated tractions offers the best outcome.
   Summary
   The key to optimizing outcome is early abdominal closure within 7 days because failure to do so will increase morbidity, mortality and fistulae formation. Novel techniques complementing existing de-resuscitation techniques are discussed.
C1 [Sugrue, Michael] Letterkenny Univ Hosp, Donegal Clin Res Acad Ireland, Dept Surg, Donegal, Ireland.
RP Sugrue, M (通讯作者)，Letterkenny Univ Hosp, Kilmacrennan Rd, Letterkenny, Ireland.
EM acstrauma@hotmail.com
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NR 30
TC 19
Z9 23
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1070-5295
EI 1531-7072
J9 CURR OPIN CRIT CARE
JI Curr. Opin. Crit. Care
PD FEB
PY 2017
VL 23
IS 1
BP 73
EP 78
DI 10.1097/MCC.0000000000000371
PG 6
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EH7LM
UT WOS:000391954500012
PM 27941356
DA 2026-07-24
ER
PT J
AU Jentzsch, T
   Osterhoff, G
   Zwolak, P
   Seifert, B
   Neuhaus, V
   Simmen, HP
   Jukema, GN
AF Jentzsch, Thorsten
   Osterhoff, Georg
   Zwolak, Pawel
   Seifert, Burkhardt
   Neuhaus, Valentin
   Simmen, Hans-Peter
   Jukema, Gerrolt N.
TI Bacterial reduction and shift with NPWT after surgical debridements: a
   retrospective cohort study
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE Bacterial reduction; Bacterial shift; Negative-pressure wound therapy
   (NPWT); Vacuum-assisted closure (VAC); Gram-staining; Oxygen use
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; TOPICAL
   NEGATIVE-PRESSURE; OPEN FRACTURES; CONTAMINATION; INFECTIONS;
   MANAGEMENT; SURGERY; LOAD
AB Surgical debridement, negative-pressure wound therapy (NPWT) and antibiotics are used for the treatment of open wounds. However, it remains unclear whether this treatment regimen is successful in the reduction and shift of the bacterial load.
   After debridement in the operating room, NPWT, and antibiotic treatment, primary and secondary consecutive microbiological samples of 115 patients with 120 open wounds with bacterial or yeast growth in 1 swab or tissue microbiological sample(s) were compared for bacterial growth, Gram staining and oxygen use at a level one trauma center in 2011.
   Secondary samples had significantly less bacterial growth (32 vs. 89%, p < .001, OR 17), Gram-positive bacteria (56 vs. 78%, p = .013), facultative anaerobic bacteria (64 vs. 85%, p = .011) and Staphylococcus aureus (10 vs. 46%, p = .002). They also tended to include relatively more Coagulase-negative Staphylococci (CoNS) (44 vs. 18%) and Pseudomonas species (spp.) (31 vs. 7%). Most (98%) wounds were successfully closed within 11 days, while wound revision was needed in 4%.
   The treatment regimen of combined use of repetitive debridement, irrigation and NPWT in an operating room with antibiotics significantly reduced the bacterial load and led to a shift away from Gram-positive bacteria, facultative anaerobic bacteria, and S. aureus, as well as questionably toward CoNS and Pseudomonas spp. in this patient cohort. High rates of wound closure were achieved in a relatively short time with low revision rates. Whether each modality played a role for these findings remains unknown.
C1 [Jentzsch, Thorsten; Osterhoff, Georg; Zwolak, Pawel; Neuhaus, Valentin; Simmen, Hans-Peter; Jukema, Gerrolt N.] Univ Zurich, Univ Zurich Hosp, Div Trauma Surg, Dept Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
   [Seifert, Burkhardt] Univ Zurich, Dept Biostat, Epidemiol Biostat & Prevent Inst, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; Swiss School of Public
   Health (SSPH+); University of Zurich
RP Jentzsch, T (通讯作者)，Univ Zurich, Univ Zurich Hosp, Div Trauma Surg, Dept Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM thorsten.jentzsch@gmail.com
RI ; Jentzsch Epidemiology, PD med Thorsten/AAR-6135-2020; Osterhoff,
   Georg/IXW-9149-2023; Jentzsch, Thorsten/AAR-6135-2020
OI Seifert, Burkhardt/0000-0002-5829-2478; Jentzsch Epidemiology, PD med
   Thorsten/0000-0002-6133-3314; Osterhoff, Georg/0000-0001-5051-0998;
   Neuhaus, Valentin/0000-0003-4012-5628; Simmen,
   Hans-Peter/0000-0002-5201-4549
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NR 38
TC 15
Z9 21
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD JAN
PY 2017
VL 137
IS 1
BP 55
EP 62
DI 10.1007/s00402-016-2600-z
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA EH9WM
UT WOS:000392122400008
PM 27988849
DA 2026-07-24
ER
PT J
AU Seternes, A
   Rekstad, LC
   Mo, S
   Klepstad, P
   Halvorsen, DL
   Dahl, T
   Björck, M
   Wibe, A
AF Seternes, A.
   Rekstad, L. C.
   Mo, S.
   Klepstad, P.
   Halvorsen, D. L.
   Dahl, T.
   Bjorck, M.
   Wibe, A.
TI Open Abdomen Treated with Negative Pressure Wound Therapy: Indications,
   Management and Survival
SO WORLD JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT 7th World Congress on the Abdominal Compartment Syndrome
CY MAY, 2015
CL Ghent, BELGIUM
ID ABDOMINAL COMPARTMENT SYNDROME; MEDIATED FASCIAL TRACTION;
   INTRAABDOMINAL HYPERTENSION; CLOSURE; VACUUM; CLASSIFICATION; TRAUMA;
   ETAPPENLAVAGE; DECOMPRESSION; LAPAROTOMY
AB Open abdomen treatment (OAT) is a significant burden for patients and is associated with considerable mortality. The primary aim of this study was to report survival and cause of mortality after OAT. Secondary aims were to evaluate length of stay (LOS) in intensive care unit (ICU) and in hospital, time to abdominal closure and major complications.
   Retrospective review of prospectively registered patients undergoing OAT between October 2006 and June 2014 at Trondheim University Hospital, Norway.
   The 118 patients with OAT had a median age of 63 (20-88) years. OAT indications were abdominal compartment syndrome (ACS) (n = 53), prophylactic (n = 29), abdominal contamination/second look laparotomy (n = 22), necrotizing fasciitis (n = 7), hemorrhage packing (n = 4) and full-thickness wound dehiscence (n = 3). Eight percent were trauma patients. Vacuum-assisted wound closure (VAWC) with mesh-mediated traction (VAWCM) was used in 92 (78 %) patients, the remaining 26 (22 %) had VAWC only. Per-protocol primary fascial closure rate was 84 %. Median time to abdominal closure was 12 days (1-143). LOS in the ICU was 15 (1-89), and in hospital 29 (1-246) days. Eighty-one (68 %) patients survived the hospital stay. Renal failure requiring renal replacement therapy (RRT) (OR 3.9, 95 % CI 1.37-11.11), ACS (OR 3.1, 95 % CI 1.19-8.29) and advanced age (OR 1.045, 95 % CI 1.004-1.088) were independent predictors of mortality in multivariate analysis. The nine patients with an entero-atmospheric fistula (EAF) survived.
   Two-thirds of the patients treated with OAT survived. Renal failure with RRT, ACS and advanced age were predictors of mortality, whereas EAF was not associated with increased mortality.
C1 [Seternes, A.; Dahl, T.] Univ Trondheim Hosp, St Olavs Hosp, Dept Vasc Surg, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.
   [Rekstad, L. C.; Wibe, A.] Univ Trondheim Hosp, St Olavs Hosp, Dept Gastrointestinal Surg, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.
   [Mo, S.; Klepstad, P.] Univ Trondheim Hosp, St Olavs Hosp, Dept Anesthesiol, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.
   [Mo, S.; Klepstad, P.] Univ Trondheim Hosp, St Olavs Hosp, Dept Intens Care Med, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.
   [Halvorsen, D. L.] Univ Trondheim Hosp, St Olavs Hosp, Dept Urol Surg, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.
   [Bjorck, M.] Uppsala Univ, Vasc Surg Sect, Dept Surg Sci, S-75185 Uppsala, Sweden.
   [Seternes, A.; Wibe, A.] Norwegian Univ Sci & Technol NTNU, Dept Canc Res, Hogskoleringen 1, N-7491 Trondheim, Norway.
   [Seternes, A.; Wibe, A.] Norwegian Univ Sci & Technol NTNU, Dept Mol Med, Hogskoleringen 1, N-7491 Trondheim, Norway.
   [Seternes, A.; Klepstad, P.; Dahl, T.] Norwegian Univ Sci & Technol NTNU, Dept Circulat, N-7006 Trondheim, Norway.
   [Seternes, A.; Klepstad, P.; Dahl, T.] Norwegian Univ Sci & Technol NTNU, Dept Med Imaging, N-7006 Trondheim, Norway.
C3 Norwegian University of Science & Technology (NTNU); Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU); Norwegian University of Science &
   Technology (NTNU); Norwegian University of Science & Technology (NTNU);
   Uppsala University; Norwegian University of Science & Technology (NTNU);
   Norwegian University of Science & Technology (NTNU); Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU)
RP Seternes, A (通讯作者)，Univ Trondheim Hosp, St Olavs Hosp, Dept Vasc Surg, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.; Seternes, A (通讯作者)，Norwegian Univ Sci & Technol NTNU, Dept Canc Res, Hogskoleringen 1, N-7491 Trondheim, Norway.; Seternes, A (通讯作者)，Norwegian Univ Sci & Technol NTNU, Dept Mol Med, Hogskoleringen 1, N-7491 Trondheim, Norway.; Seternes, A (通讯作者)，Norwegian Univ Sci & Technol NTNU, Dept Circulat, N-7006 Trondheim, Norway.; Seternes, A (通讯作者)，Norwegian Univ Sci & Technol NTNU, Dept Med Imaging, N-7006 Trondheim, Norway.
EM Arne.seternes@stolav.no; Lars.C.Rekstad@stolav.no; Skule.Mo@stolav.no;
   Pal.Klepstad@ntnu.no; Dag.Linthoe.Halvorsen@stolav.no;
   Torbjorn.Dahl@stolav.no; Martin.Bjorck@surgsci.uu.se; Arne.Wibe@ntnu.no
FU St. Olavs Hospital
FX Main investigator received unrestricted grants from St. Olavs Hospital.
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NR 49
TC 23
Z9 33
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD JAN
PY 2017
VL 41
IS 1
BP 152
EP 161
DI 10.1007/s00268-016-3694-8
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA EI0EY
UT WOS:000392147000023
PM 27541031
DA 2026-07-24
ER
PT J
AU Pearce, FB
   Richardson, KA
AF Pearce, F. B., Jr.
   Richardson, K. A.
TI Negative pressure wound therapy, staged excision and definitive closure
   with split-thickness skin graft for axillary hidradenitis suppurativa: a
   retrospective study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hidradenitis suppurativa; split-thickness skin graft; negative pressure
   wound therapy
AB Objective: Bilateral axillary hidradenitis is a chronic, suppurative, and scarring disease that is most effectively treated by complete excision of all hair-bearing tissues. We assessed our staged procedure for excision and placement of a split-thickness skin graft for bilateral axillary hidradenitis in terms of costs, outcomes, and timing of excision.
   Method: An IRB approved retrospective case analysis was performed on patients that underwent bilateral axillary hidradenitis skin excision with eventual placement of split-thickness skin grafting using the current LSUHSC/University Health hidradenitis surgical treatment protocol. Using ICD-9 codes (705.83) and CPT codes (11041, 11042, 11451, 11600, 11601, 11602, 11603, 11604) we reviewed cases performed at our institution from 1 January 2008 to 24 Febuary 2014 and we selected patients based on bilateral axillary involvement (alone) and > 1 year history of active disease. Patients were excluded if resection of tissue encompassed regions outside of the immediately adjacent axillary.
   Results: A total of seven patients matching criteria for bilateral axillary hidradenitis were selected for analysis. Clinical course, cost, and surgical techniques were assessed. Of the seven patients, six required admission throughout their treatment due to lack of funding making use of negative pressure wound therapy at home not possible. These patients stayed an average of 10 days with a mean hospital charge of $35,178 and a mean hospital provider charge of $10,019. No recurrence was demonstrated. All patients attained full range of motion, post grafting. No patient required a further operation due to graft failure.
   Conclusion: Split-thickness skin grafting without use of bilayer dermal regenerative templates yielded definitive results with acceptable cosmesis and functionality, without the added cost of treatments such as a bilayer dermal regenerative template.
C1 [Pearce, F. B., Jr.; Richardson, K. A.] Louisiana State Univ, Hlth Sci Ctr LSUHSC, Dept Gen Burn Surg, Baton Rouge, LA 70803 USA.
C3 Louisiana State University System; Louisiana State University
RP Pearce, FB (通讯作者)，Louisiana State Univ, Hlth Sci Ctr LSUHSC, Dept Gen Burn Surg, Baton Rouge, LA 70803 USA.
EM fbpearce@gmail.com; kricha3@lsuhsc.edu
CR Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
   [Anonymous], FERRIS CLIN ADVISOR
   [Anonymous], CLIN DERMATOLOGY
   Caldwell N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055491
   Gonzaga TA, 2013, J BURN CARE RES, V34, P51, DOI 10.1097/BCR.0b013e31826a7be7
   Holtzman L.C., 2010, CLIN PROCEDURES EMER
   Layton A, 2010, OXFORD TXB MED
   Menderes A, 2010, INT J MED SCI, V7, P240
   Townsend C.M., 2008, SABISTON TXB MODERN
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NR 10
TC 17
Z9 18
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2017
VL 26
IS 1
SU S
BP S36
EP S42
DI 10.12968/jowc.2017.26.Sup1.S36
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EI3XQ
UT WOS:000392426600005
PM 28105901
DA 2026-07-24
ER
PT J
AU Yu, YC
   Song, ZG
   Xu, ZY
   Ye, XF
   Xue, CY
   Li, JH
   Bi, HD
AF Yu, Yongchao
   Song, Zhigang
   Xu, Zhiyun
   Ye, Xiaofei
   Xue, Chunyu
   Li, Junhui
   Bi, Hongda
TI Bilayered negative-pressure wound therapy preventing leg incision
   morbidity in coronary artery bypass graft patients A randomized
   controlled trial
SO MEDICINE
LA English
DT Article
DE bilayered negative pressure wound therapy (b-NPWT); coronary artery
   bypass graft (CABG); great saphenous veins; lymphorrhagia
ID VACUUM-ASSISTED CLOSURE; LYMPH-NODE DISSECTION; INTERNAL THORACIC
   ARTERY; MICROVASCULAR BLOOD-FLOW; COMPLICATIONS
AB Backgrounds: The harvesting of great saphenous veins for coronary artery bypass graft (CABG) patients may result in significant complications, including lymphorrhagia, lymphoedema, incision infection, wound dehiscence, and skin flap necrosis. We investigated the function of a self-designed bilayered negative pressure wound therapy (b-NPWT) for reducing the above-mentioned complications using a clinical randomized controlled trial.
   Methods: A single-center, pilot randomized controlled trial was conducted. From December 2013 to March 2014, a total of 72 coronary heart disease patients (48 men and 24 women) received CABG therapy, with great saphenous veins were selected as grafts. Patients were equally randomized into a treatment and a control group. After the harvesting of the great saphenous veins and direct closure of the wound with sutures, b-NPWT was used for the thigh incision in the treatment group for 5 days (treatment thigh). Traditional surgical pads were applied to both the shank incisions of the treatment group patients (treatment shank) and the entire incisions of the control group (control thigh, control shank). Postoperative complications were recorded and statistically analyzed based on outcomes of thigh treatment, shank treatment, thigh control, and shank control groups.
   Results: The incidence rates of early complications, such as lymphorrhagia, lymphoedema, infection, wound dehiscence, and skin flap necrosis, of the vascular donor site in the thigh treatment group was significantly lower than those in the 3 other groups.
   Conclusions: The self-designed b-NPWT can effectively reduce postoperative complications, such as lymphedema, incision infection, wound dehiscence, and skin flap necrosis, in CABG patients who underwent great saphenous veins harvesting.
C1 [Yu, Yongchao; Song, Zhigang; Xu, Zhiyun] Second Mil Med Univ, Changhai Hosp, Dept Cardiac Surg, Shanghai 200433, Peoples R China.
   [Ye, Xiaofei] Second Mil Med Univ, Changhai Hosp, Dept Stat, Fac Med Serv, Shanghai 200433, Peoples R China.
   [Xue, Chunyu; Li, Junhui; Bi, Hongda] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Naval Medical University; Naval Medical
   University
RP Xue, CY; Li, JH; Bi, HD (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM xcyfun@sina.com; Lissot@163.com; bihongda0411@163.com
OI ye, xiaofei/0000-0003-3692-1285
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 35
TC 11
Z9 13
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2017
VL 96
IS 3
AR e5925
DI 10.1097/MD.0000000000005925
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EI4TR
UT WOS:000392486800031
PM 28099357
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Krticka, M
   Ira, D
   Bilik, A
   Rotschein, P
   Svancara, J
AF Krticka, M.
   Ira, D.
   Bilik, A.
   Rotschein, P.
   Svancara, J.
TI Fasciotomy closure using negative pressure wound therapy in lower leg
   compartment syndrome
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE lower leg; acute compartment syndrome; NPWT; split thickness graft;
   fasciotomy; wound closure
ID VACUUM-ASSISTED CLOSURE; INCISION FASCIOTOMY; TIBIAL FRACTURES;
   SINGLE-INCISION; COMPLICATIONS; DEVICE; TRAUMA
AB BACKGROUND: Fasciotomy wounds can be a major contributor to length of stay for patients as well as a difficult reconstructive challenge.
   OBJECTIVES: To evaluate lower leg fasciotomy wound closure outcomes comparing treatment with combined dressing fabric (COM) and negative pressure wound therapy (NPWT) in combination with elastic dynamic ligature (EDL).
   METHODS: Retrospective study of 63 patients who underwent lower leg fasciotomy due to injury treated from January 2008 to December 2015 at the Department of Trauma Surgery, University Hospital Brno. Of these fasciotomy wounds 42 received a NPWT treatment in combination with EDL, 21 were treated only with COM. Fasciotomy wounds were closed either with primary suture or in case of persisting oedema and skin retraction the defect was covered with split thickness skin graft.
   RESULTS: There was statistically significantly higher rate of primary wound closure using the NPWT versus traditional dressing (p = 0.015). Median time to definitive wound closure or skin grafting was shorter in the NPWT group. Number of dressing changes was lower in the NPWT group (p=0.008).
   CONCLUSION: NPWT combined with elastic dynamic ligature offers many advantages for fasciotomy wound closure in comparison with traditional techniques (Tab. 5, Fig. 3, Ref. 21). Text in PDF www.elis.sk.
C1 [Krticka, M.; Ira, D.; Bilik, A.; Rotschein, P.] Univ Hosp, Dept Trauma Surg, Brno, Czech Republic.
   [Svancara, J.] Masaryk Univ, Inst Biostat & Anal, Brno, Czech Republic.
C3 University Hospital Brno; Institute of Biostatistics & Analyses; Masaryk
   University
RP Krticka, M (通讯作者)，Univ Hosp, Dept Trauma Surg, Brno, Czech Republic.; Krticka, M (通讯作者)，Dept Trauma Surg, Jihlavska 20, C-60200 Brno, Czech Republic.
EM milan.krticka@fnbrno.cz
RI Ira, Daniel/ABD-7164-2020; Krtička, Milan/ABE-1428-2020; Rotschein,
   Pavel/ABF-9297-2020; Švancara, Jan/G-5285-2017
OI Ira, Daniel/0000-0002-7332-9830; Krtička, Milan/0000-0002-7101-1896; 
CR Al-Dadah OQ, 2008, INJURY, V39, P1204, DOI 10.1016/j.injury.2008.03.029
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NR 21
TC 13
Z9 16
U1 0
U2 9
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2016
VL 117
IS 12
BP 710
EP 714
DI 10.4149/BLL_2016_136
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EI5VQ
UT WOS:000392564800005
PM 28127967
OA gold
DA 2026-07-24
ER
PT J
AU Anghel, EL
   DeFazio, MV
   Barker, JC
   Janis, JE
   Attinger, CE
AF Anghel, Ersilia L.
   DeFazio, Michael V.
   Barker, Jenny C.
   Janis, Jeffrey E.
   Attinger, Christopher E.
TI Current Concepts in Debridement: Science and Strategies
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID PRESSURE WOUND THERAPY; PSEUDOMONAS-AERUGINOSA BIOFILM; DIABETIC FOOT
   ULCERS; IN-VITRO; ANTIBIOTIC-RESISTANCE; SURGICAL DEBRIDEMENT; BACTERIAL
   BIOFILMS; SENESCENT CELLS; INFECTIONS; MANAGEMENT
AB Background: The establishment of a healthy wound bed through adequate debridement of infected, senescent, and/or devitalized tissue is central to the progression of normal wound healing. Although a variety of surgical and nonsurgical strategies have been proposed, none have proven completely effective in all settings. This review focuses on the principles and techniques of modern debridement practices employed in the management of complex wounds.
   Methods: A comprehensive review of the PubMed/Medline and Ovid databases was performed to identify basic science and clinical studies using key words most relevant to biofilm, debridement, and wound healing. English language articles that were peer reviewed and that met the standard of evidence-based medicine were included. Level of evidence for various debridement approaches was rated utilizing the American Society of Plastic Surgeons Rating Levels of Evidence and Grading Recommendations.
   Results: The value of both operative and nonoperative debridement techniques, their indications, and limitations are described. With an emphasis placed on surgical debridement, this review highlights technical adjuncts that can be used to optimize wound bed preparation, including preoperative topical staining of the wound, as well as the use of color-guided endpoints to prevent removal of excess healthy tissue. The indications for using temporizing measures for wound control such as negative pressure wound therapy with and without installation are also discussed.
   Conclusion: Optimal management requires a multimodal approach that centers around operative debridement and incorporates the use of adjunctive measures to facilitate the removal of infected tissue, biofilm, and/or senescent cells that impede the progression of normal wound healing.
C1 MedStar Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
   Ohio State Univ, Med Ctr, Dept Plast Surg, Columbus, OH 43210 USA.
C3 Georgetown University; University System of Ohio; Ohio State University
RP Janis, JE (通讯作者)，Ohio State Univ, Wexner Med Ctr, Univ Hosp, Dept Plast Surg, 915 Olentangy River Rd,Suite 2100,Room 2114, Columbus, OH 43212 USA.
EM Jeffrey.Janis@osumc.edu
RI Barker, Jenny/KYR-0129-2024; Janis, Jeffrey/W-6760-2019
OI Barker, Jenny/0000-0002-1517-5124; Janis, Jeffrey/0000-0001-6103-4798
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NR 79
TC 58
Z9 71
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2016
VL 138
SU S
BP 82S
EP 93S
DI 10.1097/PRS.0000000000002651
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EI6PQ
UT WOS:000392618300011
PM 27556779
DA 2026-07-24
ER
PT J
AU Anghel, EL
   Kim, PJ
AF Anghel, Ersilia L.
   Kim, Paul J.
TI Negative-Pressure Wound Therapy: A Comprehensive Review of the Evidence
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; THICKNESS
   SKIN-GRAFTS; DIABETIC FOOT ULCERS; MULTICENTER; INSTILLATION; FRACTURES;
   FOAM
AB Background: Negative-pressure wound therapy (NPWT) and its variations are an established adjunctive modality for the treatment of wounds. Since its introduction, there have been an increasing number of publications with periods of rapid increases in the number of publications after innovations to the technology. Its application in different wound types and varying clinical scenarios has also contributed to the growing number of publications.
   Methods: A comprehensive literature review (1998-2016) was performed using key words most relevant to NPWT using PubMed/Medline and OVID. Eligibility criteria included higher level evidence studies.
   Results: One thousand three hundred and forty-seven publications were identified. A total of 26 publications are included in this review: 16 comparing NPWT with standard wound dressing, 6 comparing variations of NPWT, and 4 for NPWT with instillation. The level of evidence, wound type studied, reported outcomes and impact, and key findings are tabulated and discussed.
   Conclusions: The number of publications has grown significantly since the inception of NPWT. In part, this reflects the variations of NPWT that have developed. However, a greater number of robust, randomized, prospective studies are needed to support its wide spread use.
C1 MedStar Georgetown Univ Hosp, Dept Plast Surg, Div Wound Healing & Hyperbar Med, Washington, DC USA.
   [Kim, Paul J.] Georgetown Univ, Sch Med, Dept Plast Surg, Div Wound Healing & Hyperbar Med, 3800 Reservoir RD NW, Washington, DC 20007 USA.
C3 Georgetown University; Georgetown University
EM paul.j.kim@gunet.georgetown.edu
OI , Paul/0000-0002-6186-6890
FU KCI, an ACELITY Company
FX P. J. Kim has received research and consulting funding from KCI, an
   ACELITY Company, a manufacturer of negative-pressure wound therapy
   devices. E. L. Anghel has nothing to disclose.
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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NR 30
TC 59
Z9 79
U1 3
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2016
VL 138
SU S
BP 129S
EP 137S
DI 10.1097/PRS.0000000000002645
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EI6PQ
UT WOS:000392618300017
PM 27556753
DA 2026-07-24
ER
PT J
AU Driver, VR
   Eckert, KA
   Carter, MJ
   French, MA
AF Driver, Vickie R.
   Eckert, Kristen A.
   Carter, Marissa J.
   French, Michael A.
TI Cost-effectiveness of negative pressure wound therapy in patients with
   many comorbidities and severe wounds of various etiology
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ELECTRIC-STIMULATION THERAPY; DIABETIC FOOT
   ULCERS; CARE; UTILITY
AB This study analyzed a cross-section of patients with severe chronic wounds and multiple comorbidities at an outpatient wound clinic, with regard to the cost-effectiveness and cost-benefit of negative pressure wound therapy (intervention) vs. no negative pressure wound therapy (control) at 1 and 2 years. Medicare reimbursement charges for wound care were used to calculate costs. Amputation charges were assessed using diagnosis-related groups. Cost-benefit analysis was based on ulcer-free months and cost-effectiveness on quality-adjusted life-years. Undiscounted costs, benefits, quality-adjusted life-years, undiscounted and discounted incremental net health benefits, and incremental cost-effectiveness ratios were calculated for unmatched and matched cohorts. There were 150 subjects in the intervention group and 154 controls before matching and 103 subjects in each of the matched cohorts. Time to heal for the intervention cohort was significantly shorter compared to the controls (270 vs. 635 days, p=1.0 x 10(-7), matched cohorts). The intervention cohort had higher benefits and quality-adjusted life-year gains compared to the control cohort at years 1 and 2; by year 2, the gains were 68-73% higher. In the unmatched cohorts, the incremental net health benefit was $9,933 per ulcer-free month at year 2 for the intervention; the incremental cost-effectiveness ratio was -825,271 per quality-adjusted life-year gained (undiscounted costs and benefits). For the matched cohorts, the incremental net health benefits was only $1,371 per ulcer-free month for the intervention, but the incremental cost-effectiveness ratio was $366,683 per quality-adjusted life-year gained for year 2 (discounted costs and benefits). In a patient population with severe chronic wounds and serious comorbidities, negative pressure wound therapy resulted in faster healing wounds and was more cost-effective with greater cost-benefits than not using negative pressure wound therapy. Regarding overall cost-effectiveness, the intervention was still expensive, but that is the reality amidst limited treatment options for such serious cases of chronic wounds.
C1 [Driver, Vickie R.] Brown Univ, Sch Med, Providence, RI 02912 USA.
   [Driver, Vickie R.] Rhode Isl Hosp, HBO & Wound Healing Ctr, Providence, RI USA.
   [Driver, Vickie R.] Novartis Inst Biomed Res, New Indicat Discovery Unit, Cambridge, MA USA.
   [Eckert, Kristen A.; Carter, Marissa J.] Strateg Solut Inc, Cody, WY USA.
   [French, Michael A.] VA Providence Med Ctr, Providence, RI USA.
C3 Brown University; Lifespan Health Rhode Island; Rhode Island Hospital;
   Novartis; Novartis USA
RP Driver, VR (通讯作者)，830 Chalkstone Ave, Providence, RI 02908 USA.
EM drvdriver@aol.com
FU KCI, An Acelity Company, San Antonio, TX
FX KCI, An Acelity Company, San Antonio, TX.
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NR 26
TC 18
Z9 21
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2016
VL 24
IS 6
BP 1041
EP 1058
DI 10.1111/wrr.12483
PG 18
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA EI9JV
UT WOS:000392825000135
PM 27669667
DA 2026-07-24
ER
PT J
AU Dalla Paola, L
   Carone, A
   Boscarino, G
   Scavone, G
   Vasilache, L
AF Dalla Paola, Luca
   Carone, Anna
   Boscarino, Giulio
   Scavone, Giuseppe
   Vasilache, Lucian
TI Combination of Open Subtotal Calcanectomy and Stabilization With
   External Fixation as Limb Salvage Procedure in Hindfoot-Infected
   Diabetic Foot Ulcers
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE diabetic foot ulcer; osteomyelitis; foot infection; diabetic foot
   surgery
ID HEEL; OSTEOMYELITIS; ULCERATIONS; AMPUTATION; ALGORITHM
AB Diabetic hindfoot ulcers, complicated by osteomyelitis, are associated with a high risk of major amputation. Partial calcanectomy, preceded by an effective management of the infection and of the eventual peripheral artery disease, can be considered as valid therapeutic option. We have evaluated a therapeutic protocol for diabetic hindfoot ulcers complicated by osteomyelitis, which, besides an adequate surgical debridement, considers a reconstructive pathway assisted by the positioning of a circular external fixator. We made a prospective study of a cohort of diabetic patients affected by heel ulcer complicated by osteomyelitis. All patients underwent open partial calcanectomy associated with the positioning of a circular external frame specifically designed for hindfoot stabilization and offloading. A reconstructive procedure was implemented starting with the application of negative pressure wound therapy and coverage with dermal substitute and split thickness skin grafting. From November 2014 to November 2015, 18 consecutive patients were enrolled. Mean follow-up period was 212.3 +/- 64.0 days. Healing was achieved in 18 (100%) patients. The mean healing time was 69.0 +/- 64.0 days. No major amputation had to be performed during the follow-up. Open partial calcanectomy associated with external fixation and skin reconstruction was as efficient as limb salvage in patients with infected lesions of the hindfoot complicated by calcaneal osteomyelitis.
C1 [Dalla Paola, Luca; Carone, Anna; Boscarino, Giulio; Scavone, Giuseppe; Vasilache, Lucian] Maria Cecilia Hosp, GVM Care & Res, Cotignola, Italy.
C3 Maria Cecilia Hospital
RP Dalla Paola, L (通讯作者)，Maria Cecilia Hosp, Diabet Foot Dept, GVM Care & Res, Via Corriera 1, I-48010 Cotignola, RA, Italy.
EM ldallapaola@libero.it
CR Attinger C., 2011, AM COLL WOUND HEAL T
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NR 42
TC 16
Z9 18
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2016
VL 15
IS 4
BP 332
EP 337
DI 10.1177/1534734616667865
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EJ0FF
UT WOS:000392883300008
PM 27694302
DA 2026-07-24
ER
PT J
AU Parrado, R
   Cadena, M
   Vergara, A
   Cadena, D
   Chalela, JG
AF Parrado, Raphael
   Cadena, Manuel
   Vergara, Arturo
   Cadena, Diana
   Chalela, Juan G.
TI The role of negative pressure wound therapy in the management of
   hidradenitis suppurativa: a case report and literature review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Acne inversa; Hidradenitis suppurativa; Negative pressure wound therapy;
   Split-thickness skin grafting
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; AXILLARY HIDRADENITIS;
   SURGICAL-MANAGEMENT; DRESSINGS; PREVALENCE; EXCISION; SMOKING
AB Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic, recurrent inflammatory disease affecting skin that bears apocrine glands. It is characterised by the presence of tender subcutaneous nodules that may rupture, resulting in deep dermal abscesses, fibrosis with dermal contractures and induration of the skin. The management of HS is a challenge for physicians as the pathogenesis is not clearly defined and prevents the use and development of directed therapies. Treatment options are oral agents (antibiotics, immunomodulators) and surgical excision. Historically, surgical management has been complicated by difficult closure and high recurrent rates. In the last 10 years, negative pressure wound therapy (NPWT) has proven to be a great adjunct for wound management as it provides the adequate conditions for wound healing, promotes granulation and helps to control infection. Here, we report a case of severe perineal HS treated with radical excision and NPWT as an adjunct. The patient only had a recurrence 3 years after primary treatment and was surgically treated for cosmetic reasons without any complications. Finally, we present a review of the relevant literature.
C1 [Parrado, Raphael; Cadena, Manuel; Vergara, Arturo] Fdn Santa Fe Bogota, Dept Gen Surg, Ave 9 117-20,Cons 932, Bogota 2152300, Colombia.
   [Cadena, Diana] Fdn Santa Fe Bogota, Dept Plast Surg, Bogota, Colombia.
   [Chalela, Juan G.] Fdn Santa Fe Bogota, Dept Dermatol, Bogota, Colombia.
RP Cadena, M (通讯作者)，Fdn Santa Fe Bogota, Dept Gen Surg, Ave 9 117-20,Cons 932, Bogota 2152300, Colombia.
EM manuelcade@gmail.com
OI Parrado, Raphael/0000-0003-0388-3948
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NR 45
TC 15
Z9 17
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2017
VL 14
IS 1
BP 35
EP 39
DI 10.1111/iwj.12544
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EJ0RX
UT WOS:000392919100006
PM 26663439
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Rashed, A
   Frenyo, M
   Gombocz, K
   Szabados, S
   Alotti, N
AF Rashed, Aref
   Frenyo, Magdolna
   Gombocz, Karoly
   Szabados, Sandor
   Alotti, Nasri
TI Incisional negative pressure wound therapy in reconstructive surgery of
   poststernotomy mediastinitis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Failure of treatment; Incisional negative pressure wound therapy;
   Poststernotomy mediastinitis; Redon drains
ID INFECTIONS
AB The efficacy of negative pressure wound therapy in the treatment of poststernotomy mediastinitis has been revealed in many reports. The present retrospective observational study examined the efficacy of incisional negative pressure wound therapy in the reconstructive surgery of poststernotomy mediastinitis. We retrospectively examined 1034 consecutive patients, who underwent median sternotomy in the period between October 2013 and September 2015. Mediastinitis developed in 21 patients (2%), who subsequently underwent surgical reconstruction. We applied incisional negative pressure wound therapy (iNPWT) after primary closure of the wound over redon drains in ten patients (iNPWT + redon group). In 11 patients, only redons were used (redons only group). We observed the time between the introduction and removal of redon drains, hospital stay until final wound closure and the rate of failure of treatment. Failure of treatment is defined as the need for further surgical reconstruction. In the iNPWT + redon group, the duration of redon drainage therapy was 6<bold></bold>9 +/- 5<bold></bold>2 days versus 13<bold></bold>36 +/- 11<bold></bold>58 in the redons only group. Hospital stay was 11<bold></bold>4 +/- 8<bold></bold>6 versus 101<bold></bold>64 +/- 89<bold></bold>2, and failure of treatment was 10% versus 45<bold></bold>5%, respectively. The primary results of this study appear to support the beneficial effect of iNPWT after radical wound reconstruction.
C1 [Rashed, Aref; Frenyo, Magdolna; Gombocz, Karoly; Alotti, Nasri] Univ Pecs, Zala Cty Hosp, Dept Cardiac Surg, Zrinyi Str 1, H-8900 Zalaegerszeg, Hungary.
   [Szabados, Sandor] Univ Pecs, Dept Cardiac Surg, Pecs, Hungary.
C3 University of Pecs; University of Pecs
RP Rashed, A (通讯作者)，Univ Pecs, Zala Cty Hosp, Dept Cardiac Surg, Zrinyi Str 1, H-8900 Zalaegerszeg, Hungary.
EM aref.rashed.szv@zmkorhaz.hu
RI /AAO-3555-2020
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
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NR 9
TC 11
Z9 12
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2017
VL 14
IS 1
BP 180
EP 183
DI 10.1111/iwj.12579
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EJ0RX
UT WOS:000392919100026
PM 26991312
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Daar, DA
   Wirth, GA
   Evans, GRD
   Carmean, M
   Gordon, IL
AF Daar, David A.
   Wirth, Garrett A.
   Evans, Gregory R. D.
   Carmean, Melissa
   Gordon, Ian L.
TI The Bagautdinov dressing method: negative pressure wound therapy in a
   patient with an allergy to acrylate adhesive
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Adhesive allergy; Bagautdinov dressing; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; CONTACT-DERMATITIS; MULTICENTER; ULCERS
AB Current embodiments of negative pressure wound therapy (NPWT) create a hermetically sealed chamber at the surface of the body using polyurethane foam connected to a vacuum pump, which is then covered by a flexible adhesive drape. Commercially available NPWT systems routinely use flexible polyethylene films that have a sticky side, coated with the same acrylate adhesives used in other medical devices such as ECG leads and grounding pads. Severe reactions to the acrylate adhesives in these other devices, although uncommon, have been reported. We describe the case of a 63-year-old woman with an intractable leg ulcer resulting from external-beam radiotherapy (XRT). Treatment with a standard commercial NPWT system induced severe inflammation of the skin in direct contact with drape adhesive. We successfully administered prolonged, outpatient NPWT to the patient using an alternative method (first described by Bagautdinov in 1986), using plain polyethylene film and petrolatum. The necessary hermetic seal is achieved by smearing the skin with petrolatum before applying the polyethylene film and activating the vacuum pump. The Bagautdinov method is a practical solution to the problem of adapting NPWT to patients with contact sensitivity or skin tears related to the adhesive compounds in the flexible drapes. Its use of a circumferential elastic wrap to maintain constant pressure on the seal probably limits the Bagautdinov technique to the extremities.
C1 [Daar, David A.; Wirth, Garrett A.; Evans, Gregory R. D.] Univ Calif Irvine, Aesthet & Plast Surg Inst, Irvine, CA USA.
   [Wirth, Garrett A.; Carmean, Melissa] Univ Calif Irvine, Burn & Wound Clin, Rehabilitat Serv, Irvine, CA USA.
   [Wirth, Garrett A.; Gordon, Ian L.] Long Beach Vet Affairs Hlth Care Syst, Dept Surg, Long Beach, CA 90822 USA.
   [Wirth, Garrett A.; Gordon, Ian L.] Univ Calif Irvine, Dept Surg, Irvine, CA 92717 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Long Beach Healthcare System; University of California System;
   University of California Irvine
RP Gordon, IL (通讯作者)，Long Beach Vet Affairs Hlth Care Syst, Dept Surg, Long Beach, CA 90822 USA.
EM ian.gordon@va.gov
CR [Anonymous], 2009, SMITH NEPHEW CLIN GU
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NR 29
TC 7
Z9 7
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2017
VL 14
IS 1
BP 198
EP 202
DI 10.1111/iwj.12589
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EJ0RX
UT WOS:000392919100029
PM 27212250
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Bobkiewicz, A
   Walczak, D
   Smolinski, S
   Kasprzyk, T
   Studniarek, A
   Borejsza-Wysocki, M
   Ratajczak, A
   Marciniak, R
   Drews, M
   Banasiewicz, T
AF Bobkiewicz, Adam
   Walczak, Dominik
   Smolinski, Szymon
   Kasprzyk, Tomasz
   Studniarek, Adam
   Borejsza-Wysocki, Maciej
   Ratajczak, Andrzej
   Marciniak, Ryszard
   Drews, Michal
   Banasiewicz, Tomasz
TI Management of enteroatmospheric fistula with negative pressure wound
   therapy in open abdomen treatment: a multicentre observational study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Enteroatmospheric fistula; Laparostomy; Negative pressure wound therapy;
   Open abdomen
ID VACUUM-ASSISTED CLOSURE; TEMPORARY ABDOMINAL CLOSURE; SMALL-BOWEL
   FISTULAS; ENTEROCUTANEOUS FISTULAS; ANASTOMOTIC LEAKAGE; COMPLICATIONS;
   PROPOSAL; TRAUMA
AB The management of enteroatmospheric fistula (EAF) in open abdomen (OA) therapy is challenging and associated with a high mortality rate. The introduction of negative pressure wound therapy (NPWT) in open abdomen management significantly improved the healing process and increased spontaneous fistula closure. Retrospectively, we analysed 16 patients with a total of 31 enteroatmospheric fistulas in open abdomen management who were treated using NPWT in four referral centres between 2004 and 2014. EAFs were diagnosed based on clinical examination and confirmed with imaging studies and classified into low (<200 ml/day), moderate (200-500 ml/day) and high (>500 ml/day) output fistulas. The study group consisted of five women and 11 men with the mean age of 526 years [standard deviation (SD) 119]. Since open abdomen management was implemented, the mean number of re-surgeries was 37 (SD 22). There were 24 EAFs located in the small bowel, while four were located in the colon. In three patients, EAF occurred at the anastomotic site. Thirteen fistulas were classified as low output (419%), two as moderate (65%) and 16 as high output fistulas (516%). The overall closure rate was 613%, with a mean time of 467 days (SD 434). In the remaining patients in whom fistula closure was not achieved (n = 12), a protruding mucosa was present. Analysing the cycle of negative pressure therapy, we surprisingly found that the spontaneous closure rate was 70% (7 of 10 EAFs) using intermittent setting of negative pressure, whereas in the group of patients treated with continuous pressure, 57% of EAFs closed spontaneously (12 of 21 EAFs). The mean number of NPWT dressing was 9 (SD 33; range 4-16). In two patients, we observed new fistulas that appeared during NPWT. Three patients died during therapy as a result of multi-organ failure. NPWT is a safe and efficient method characterised by a high spontaneous closure rate. However, in patients with mucosal protrusion of the EAFs, spontaneous closure appears to be impossible to achieve.
C1 [Bobkiewicz, Adam; Studniarek, Adam; Borejsza-Wysocki, Maciej; Ratajczak, Andrzej; Marciniak, Ryszard; Drews, Michal; Banasiewicz, Tomasz] Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Przybyszewskiego 49, PL-60355 Poznan, Poland.
   [Walczak, Dominik] John Paul II Mem Hosp, Dept Gen Surg, Belchatow, Poland.
   [Smolinski, Szymon] Poznan Univ Med Sci, Dept Thorac Surg, Poznan, Poland.
   [Kasprzyk, Tomasz] Reg Specialist Hosp, Dept Gen Vasc & Oncol Surg, Slupsk, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences
RP Bobkiewicz, A (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Przybyszewskiego 49, PL-60355 Poznan, Poland.
EM bobofon007@gmail.com
OI Walczak, Dominik Andrzej/0000-0001-9009-5039; Bobkiewicz,
   Adam/0000-0002-4657-5788; Marciniak, Ryszard/0000-0001-7878-7403
CR Al-Khoury G, 2008, J AM COLL SURGEONS, V206, P397, DOI 10.1016/j.jamcollsurg.2007.07.027
   [Anonymous], 2014, NPWT
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   Schniewind B, 2013, SURG ENDOSC, V27, P3883, DOI 10.1007/s00464-013-2998-0
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   Tw J, 2003, ANN SURG, V238, P349
   van Koperen PJ, 2009, SURG ENDOSC, V23, P1379, DOI 10.1007/s00464-008-0186-4
   Vargo D, 2009, AM SURGEON, V75, pS1
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   Wild T, 2007, COLORECTAL DIS, V9, P572, DOI 10.1111/j.1463-1318.2007.01309.x
NR 44
TC 41
Z9 51
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2017
VL 14
IS 1
BP 255
EP 264
DI 10.1111/iwj.12597
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EJ0RX
UT WOS:000392919100036
PM 27000995
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Matic, P
   Tanaskovic, S
   Zivic, R
   Jocic, D
   Gajin, P
   Babic, S
   Soldatovic, I
   Vucurevic, G
   Nenezic, D
   Radak, D
AF Matic, Predrag
   Tanaskovic, Slobodan
   Zivic, Rastko
   Jocic, Dario
   Gajin, Predrag
   Babic, Srdjan
   Soldatovic, Ivan
   Vucurevic, Goran
   Nenezic, Dragoslav
   Radak, Djordje
TI Negative-pressure wound therapy for deep groin vascular infections
SO SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
LA English
DT Article
DE groin infection; synthetic graft infection; negative-pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; GRAFTS; EXPERIENCE; MANAGEMENT
AB Introduction Infection of synthetic graft in the groin is a rare but devastating complication. When it occurs, several possibilities of treatment are available. Extra-anatomic reconstruction and in-situ implantation of new, infection resistant grafts are associated with high mortality and morbidity. Therefore, more conservative approach is needed in some cases. Negative-pressure wound therapy is one of the options in treating such patients.
   Objective The aim of this study was to assess the outcome for deep groin vascular graft infection treated with negative-pressure wound therapy.
   Methods Seventeen patients (19 wounds), treated for Szilagyi grade III groin infections between October 2011 and June 2014, were enrolled into this observational study.
   Results Majority of the wounds (11/19) were healed by secondary intention, and the rest of the wounds (8/19) were healed by primary intention after initial negative-pressure wound therapy and graft substitution with silver-coated prostheses or autologous artery/vein implantation. No early mortality was observed. Minor bleeding was observed in one patient. Reinfection was noted in three wounds. Only one graft occlusion was noted. Late mortality was observed in three patients.
   Conclusion Negative-pressure wound therapy seems to be safe for groin vascular graft infections and comfortable for both patient and surgeon. However, the rate of persistent infection is high. This technique, in our opinion, can be used as a "bridge" from initial wound debridement to definitive wound management, when good local conditions are achieved for graft substitution, either with new synthetic graft with antimicrobial properties or autologous artery/vein. In selected cases of deep groin infections it can be used as the only therapeutic approach in wound treatment.
C1 [Matic, Predrag; Tanaskovic, Slobodan; Jocic, Dario; Gajin, Predrag; Babic, Srdjan; Vucurevic, Goran; Nenezic, Dragoslav; Radak, Djordje] Dedinje Cardiovasc Inst, 1 Heroja Milana Tepica St, Belgrade 11000, Serbia.
   [Matic, Predrag; Tanaskovic, Slobodan; Zivic, Rastko; Gajin, Predrag; Babic, Srdjan; Nenezic, Dragoslav; Radak, Djordje] Univ Belgrade, Sch Med, Belgrade, Serbia.
   [Zivic, Rastko] Clin Ctr Dr Dragisa Misovic, Belgrade, Serbia.
   [Soldatovic, Ivan] Univ Belgrade, Inst Med Stat & Informat, Sch Med, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade
RP Matic, P (通讯作者)，Dedinje Cardiovasc Inst, 1 Heroja Milana Tepica St, Belgrade 11000, Serbia.
EM pmpmatic@gmail.com
RI ; Matic, Preag/F-7519-2013
OI Soldatovic, Ivan/0000-0003-4893-1683; Babic, Srdjan/0000-0001-9659-9190;
   Tanaskovic, Slobodan/0000-0003-4216-6693; Matic,
   Preag/0000-0002-9043-347X
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NR 15
TC 1
Z9 1
U1 0
U2 1
PU SRPSKO LEKARSKO DRUSTVO
PI BEOGRAD
PA UREDNISTVO CASOPISA SRPSKI ARHIV, UL DZORDZA VASINGTONA 19, BEOGRAD,
   11000, SERBIA
SN 0370-8179
J9 SRP ARK CELOK LEK
JI Srp. Ark. Celok. Lek.
PD NOV-DEC
PY 2016
VL 144
IS 11-12
BP 621
EP 625
DI 10.2298/SARH1612621M
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EJ4IQ
UT WOS:000393180600008
PM 29659224
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Patel, RRV
   Giaquinto-Cillers, M
   Kotze, J
   Hartnick, RS
   van der Merwe, LW
   Holford, EB
AF Patel, R. R. V.
   Giaquinto-Cillers, M.
   Kotze, J.
   Hartnick, R. S.
   van der Merwe, L. W.
   Holford, E. B.
TI Management of acute complex traumatic wound with a dermal regeneration
   template: Case report
SO SOUTH AFRICAN JOURNAL OF SURGERY
LA English
DT Article
DE reconstruction of lower limbs; dermal regeneration template; complex
   acute wounds; leg trauma; traumatic wounds
ID VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE; SKIN; THERAPY
AB Background: Acute complex traumatic wounds of the lower limbs are usually managed by a combination of multiple debridements, dressing changes, and specialized surgical procedures which may include tissue transfers for the reconstruction of the soft tissue injury. The recovery is lengthy, and the outcome dependent on the initial injury, the surgical procedures undertaken and rehabilitation programs with a multidisciplinary team.
   Methods: A nine-year-old male patient presented to Kimberly Hospital with an extensive soft tissue injury of the leg associated with a tibia fracture caused by a high velocity pedestrian vehicle accident.
   Results: A combination of proper wound care, "homemade" negative pressure wound therapy dressings, reduction of fracture and use of a dermal regeneration template over the fracture site, followed by skin grafting was used to manage the wound.
   Conclusion: The final functional and cosmetic results obtained with the case suggest that the dermal regeneration template may provide a potential alternative for coverage of complex wounds, which might include an open fracture, without the need for complex tissue transfer interventions.
C1 [Patel, R. R. V.; Giaquinto-Cillers, M.; Kotze, J.; Hartnick, R. S.; van der Merwe, L. W.; Holford, E. B.] Kimberley Hosp Complex, Dept Plast & Reconstruct Surg & Burns, Kimberley, Northern Cape P, South Africa.
RP Patel, RRV (通讯作者)，Kimberley Hosp Complex, Dept Plast & Reconstruct Surg & Burns, Kimberley, Northern Cape P, South Africa.
EM ravin.patel.3@gmail.com
CR [Anonymous], ARCH PLAST SURG
   [Anonymous], WOUNDS
   [Anonymous], ISRN ORTHOPEDICS
   [Anonymous], NEXT GENERATION PROD
   [Anonymous], ANN BURNS FIRE DISAS
   [Anonymous], 38 ANN M AM BURN ASS
   [Anonymous], J BURNS SURG WOUND C
   [Anonymous], INTERNET J ORTHOPEDI
   [Anonymous], COMPLEX WOUND MANAGE
   [Anonymous], INT WOUND J
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NR 28
TC 0
Z9 0
U1 0
U2 4
PU SA MEDICAL ASSOC
PI PRETORIA
PA BLOCK F CASTLE WALK CORPORATE PARK, NOSSOB STREET, ERASMUSKLOOF EXT3,
   PRETORIA, 0002, SOUTH AFRICA
SN 0038-2361
EI 2078-5151
J9 S AFR J SURG
JI South Afr. J. Surg.
PD NOV
PY 2016
VL 54
IS 4
BP 52
EP 57
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EJ5AJ
UT WOS:000393228600013
PM 28272857
DA 2026-07-24
ER
PT J
AU Simon, C
   Fürstenberg, CH
   Eichler, M
   Rohde, S
   Bulut, C
   Wiedenhöfer, B
AF Simon, Christian
   Fuerstenberg, Carl H.
   Eichler, Markus
   Rohde, Stefan
   Bulut, Cem
   Wiedenhoefer, Bernd
TI Management of Pharyngeal Fistulas After Anterior Cervical Spine Surgery
   A Treatment Algorithm for Severe Complications
SO CLINICAL SPINE SURGERY
LA English
DT Article
DE pharyngocutaneous fistulas; anterior cervical spine surgery; treatment
   algorithm; vascularized flap; negative pressure wound therapy
ID CLASSIFICATION-SYSTEM; INJURY; ESOPHAGEAL; RATES; SCI
AB Study Design: This study is a retrospective database query to identify all anterior spinal approaches.
   Objectives: The objectives were to assess all patients with pharyngocutaneous fistulas (PCFs) after anterior cervical spine surgery.
   Summary of Background Data: Patients with the diagnosis of PCFs were treated at the University of Heidelberg Spine Medical Center, Spinal Cord Injury Unit and Department of Otolaryngology (Germany), between 2005 and 2011.
   Methods: We conducted a retrospective study on 5 patients with PCF after anterior cervical spine surgery between 2005 and 2011 and analyzed their therapy management and outcome on the basis of the radiologic data and patient charts.
   Results: Upon presentation, 4 patients were paraplegic. Two patients had PCF arising from 1 piriform sinus, 2 patients had PCF arising from the posterior pharyngeal wall and piriform sinus combined, and 1 patient had PCF arising only from the posterior pharyngeal wall. Two patients previously underwent unsuccessful surgical repair elsewhere and 1 patient underwent a prior radiation therapy. In 3 patients, speech and swallowing could be completely restored. Two patients died, both of whom were paraplegic. The patients were needed to undergo an average of 2 or 3 procedures for complete functional recovery of primary closure with various vascularized regional flaps and refining laser procedures supplemented with the negative pressure wound therapy wherever needed.
   Conclusions: On the basis of our experience, we are able to provide a treatment algorithm that indicates that chronic, as opposed to acute, fistulas require a primary surgical closure combined with a vascularized flap that should be accompanied by the immediate application of a negative pressure wound therapy. We also conclude that particularly in paraplegic patients suffering from this complication the risk for a fatal outcome is substantial.
C1 [Simon, Christian] Univ Lausanne, CHU Vaudois, Serv Otorhinolaryngol ORL, Lausanne, Switzerland.
   [Fuerstenberg, Carl H.; Eichler, Markus; Wiedenhoefer, Bernd] Heidelberg Univ, Dept Orthoped Trauma Surg & Spinal Cord, Schlierbacher Landstr 200a, D-69118 Heidelberg, Germany.
   [Rohde, Stefan] Heidelberg Univ, Dept Neuroradiol, Heidelberg, Germany.
   [Bulut, Cem] Heidelberg Univ, Dept Otolaryngol Head & Neck Surg, Heidelberg, Germany.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg; Ruprecht Karls University Heidelberg
RP Wiedenhöfer, B (通讯作者)，Heidelberg Univ, Dept Orthoped Trauma Surg & Spinal Cord, Schlierbacher Landstr 200a, D-69118 Heidelberg, Germany.
EM bernd.wiedenhoefer@med.uni-heidelberg.de
RI ; /AAQ-3751-2021
OI Simon, Christian/0000-0002-4156-9143; 
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NR 15
TC 4
Z9 4
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2380-0186
J9 CLIN SPINE SURG
JI Clin. Spine Surg.
PD FEB
PY 2017
VL 30
IS 1
BP E25
EP E30
DI 10.1097/BSD.0b013e3182999504
PG 6
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA EJ6TJ
UT WOS:000393351400005
PM 28107239
DA 2026-07-24
ER
PT J
AU Loftus, TJ
   Jordan, JR
   Croft, CA
   Smith, RS
   Efron, PA
   Mohr, AM
   Moore, FA
   Brakenridge, SC
AF Loftus, Tyler J.
   Jordan, Janeen R.
   Croft, Chasen A.
   Smith, R. Stephen
   Efron, Philip A.
   Mohr, Alicia M.
   Moore, Frederick A.
   Brakenridge, Scott C.
TI Temporary abdominal closure for trauma and intra-abdominal sepsis:
   Different patients, different outcomes
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Damage control surgery; temporary abdominal closure; trauma; sepsis;
   primary fascial closure
ID DAMAGE-CONTROL LAPAROTOMY; PRIMARY FASCIAL CLOSURE; VENTRAL HERNIA
   REPAIR; OPEN ABDOMEN; MANAGEMENT; RESUSCITATION; COAGULOPATHY;
   APPROXIMATION; 100-PERCENT; THERAPY
AB BACKGROUND: Temporary abdominal closure (TAC) after damage control surgery (DCS) for injured patients has been generalized to septic patients. However, direct comparisons between these populations are lacking. We hypothesized that patients with intra-abdominal sepsis would have different resuscitation requirements and lower primary fascial closure rates than trauma patients.
   STUDY DESIGN: We performed a 3-year retrospective cohort analysis of patients managed with TAC for trauma (n = 77) or intra-abdominal sepsis (n = 147). All patients received negative pressure wound therapy (NPWT) TAC with intention for planned relaparotomy and sequential abdominal closure attempts at 24- to 48-hour intervals.
   RESULTS: At presentation, trauma patients had higher rates of hypothermia (31% vs. 18%), severe acidosis (27% vs. 14%), and coagulopathy (68% vs. 48%), and septic patients had higher vasopressor infusion rates (46% vs. 27%). Forty-eight hours after presentation, septic patients had persistently higher vasopressor infusion rates (37% vs. 17%), and trauma patients had received more red blood cell transfusions (6.0 U vs. 0.0 U), fresh frozen plasma (5.0 U vs. 0.0 U), and crystalloid (8,290 vs. 7,159 ml). Among patients surviving to discharge, trauma patients had higher primary fascial closure (PFC) rates (90% vs. 76%). For trauma patients, independent predictors of failure to achieve PCF were >= 2.5 L NPWT output at 48 hours, >= 10 L crystalloid administration at 48 hours, and >= 10 U PRBC + FFP at 48 hours. For septic patients, relaparotomy within 48 hours predicted successful PFC; requirement for >= 3 diagnostic/therapeutic laparotomies predicted failure to achieve PFC.
   CONCLUSIONS: Traumatic injury and intra-abdominal sepsis are associated with distinct pathophysiologic insults, resuscitation requirements, and outcomes. Failure to achieve primary fascial closure in trauma patients was attributable to the triad of hypothermia, acidosis, and coagulopathy; failure to achieve fascial closure in septic patients was dependent upon operative course. Indications and optimal techniques for TAC may differ between these populations. (Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.)
C1 [Loftus, Tyler J.; Jordan, Janeen R.; Croft, Chasen A.; Smith, R. Stephen; Efron, Philip A.; Mohr, Alicia M.; Moore, Frederick A.; Brakenridge, Scott C.] Univ Florida Hlth, Dept Surg, Gainesville, FL USA.
   [Loftus, Tyler J.; Jordan, Janeen R.; Croft, Chasen A.; Smith, R. Stephen; Efron, Philip A.; Mohr, Alicia M.; Moore, Frederick A.; Brakenridge, Scott C.] Univ Florida Hlth, Sepsis & Crit Illness Res Ctr, Gainesville, FL USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Brakenridge, SC (通讯作者)，Univ Florida Hlth, 1600 SW Archer Rd,Room M-602, Gainesville, FL 32610 USA.
EM Scott.brakenridge@surgery.ufl.edu
RI Loftus, Tyler/J-7761-2016; Brakenridge, Scott/AAD-6691-2019; Mohr,
   Alicia/E-3016-2015
OI Loftus, Tyler/0000-0001-5354-443X; Brakenridge,
   Scott/0000-0002-7327-3718; Smith, Robert/0000-0002-0455-6415; Mohr,
   Alicia/0000-0003-1732-1313
FU National Institute on Aging [P30 AG028740]; National Institute of
   General Medical Sciences (NIGMS) [R01 GM105893-01A1, P50 GM111152-01];
   NIGMS [T32 GM-08721]; National Institute of General Medical Sciences
   [T32GM008721, R01GM105893] Funding Source: NIH RePORTER; National
   Institute on Aging [P30AG028740] Funding Source: NIH RePORTER
FX The authors have no relevant conflicts of interest. This work has not
   been presented at any meetings and has never been submitted elsewhere.
   The authors were supported in part by grants P30 AG028740 (S.C.B.)
   awarded by the National Institute on Aging and by R01 GM105893-01A1
   (A.M.M.), P50 GM111152-01 (S.C.B., F.A.M., A.M.M.) awarded by the
   National Institute of General Medical Sciences (NIGMS). T.J.L. was
   supported by a postgraduate training grant (T32 GM-08721) in burns,
   trauma, and perioperative injury by NIGMS.
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NR 39
TC 23
Z9 31
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD FEB
PY 2017
VL 82
IS 2
BP 345
EP 350
DI 10.1097/TA.0000000000001283
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA EJ8GO
UT WOS:000393463600020
PM 27787442
DA 2026-07-24
ER
PT J
AU Acosta, S
   Björck, M
   Wanhainen, A
AF Acosta, S.
   Bjorck, M.
   Wanhainen, A.
TI Negative-pressure wound therapy for prevention and treatment of
   surgical-site infections after vascular surgery
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; AORTIC-ANEURYSM
   REPAIR; CLOSED INCISION MANAGEMENT; MEDIATED FASCIAL TRACTION; OPEN
   ABDOMEN TREATMENT; SZILAGYI GRADE III; INTRAABDOMINAL HYPERTENSION;
   ENDOVASCULAR REPAIR; DRESSING CHANGES
AB BackgroundIndications for negative-pressure wound therapy (NPWT) in vascular surgical patients are expanding. The aim of this review was to outline the evidence for NPWT on open and closed wounds.
   MethodsA PubMed, EMBASE and Cochrane Library search from 2007 to June 2016 was performed combining the medical subject headings terms wound infection', abdominal aortic aneurysm (AAA)', fasciotomy', vascular surgery' and NPWT' or VAC'.
   ResultsNPWT of open infected groin wounds was associated with shorter duration of wound healing by 47 days, and was more cost-effective than alginate dressings in one RCT. In one RCT and six observational studies, NPWT-related major bleeding and graft preservation rates were 0-10 and 83-100 per cent respectively. One retrospective comparative study showed greater wound size reduction per day, fewer dressing changes, quicker wound closure and shorter hospital stay with NPWT compared with gauze dressings for lower leg fasciotomy. NPWT and mesh-mediated fascial traction after AAA repair and open abdomen was associated with high primary fascial closure rates (96-100 per cent) and low risk of graft infection (0-7 per cent). One retrospective comparative study showed a significant reduction in surgical-site infection, from 30 per cent with standard wound care to 6 per cent with closed incisional NPWT.
   ConclusionNPWT has a central role in open and infected wounds after vascular surgery; the results of prophylactic care of closed incisions are promising.
C1 [Acosta, S.] Lund Univ, Dept Clin Sci, Vasc Ctr, Malmo, Sweden.
   [Bjorck, M.; Wanhainen, A.] Uppsala Univ, Dept Surg Sci, Vasc Surg, Uppsala, Sweden.
C3 Lund University; Uppsala University
RP Acosta, S (通讯作者)，Skane Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
EM stefan.acosta@telia.com
RI Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798
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NR 57
TC 50
Z9 62
U1 1
U2 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD JAN
PY 2017
VL 104
IS 2
BP E75
EP E84
DI 10.1002/bjs.10403
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EK0CL
UT WOS:000393594000009
PM 27901277
DA 2026-07-24
ER
PT J
AU Rettig, MJ
   Lischer, CJ
AF Rettig, M. J.
   Lischer, C. J.
TI Treatment of chronic septic osteoarthritis of the antebrachiocarpal
   joint with a synovial-cutaneous fistula utilising arthroscopic lavage
   combined with ultrasonic assisted wound therapy and vacuum assisted
   closure with a novel wound lavage system
SO EQUINE VETERINARY EDUCATION
LA English
DT Article
DE horse; synovial fistula; septic arthritis; multiresistant
   microorganisms; fistulating wound; chronic wound
ID INTERSYNOVIAL FISTULA; LIMB PERFUSION; HORSE; DEBRIDEMENT;
   MARBOFLOXACIN; MANAGEMENT; AMIKACIN; EFFICACY; HERNIA; FLUID
AB This case report describes the successful management of a chronic multidrug resistant infection of the antebrachiocarpal joint with a synovial-cutaneous fistula 7 weeks after initial trauma in a 14-year-old Icelandic stallion. Resolution of the multiresistant Enterobacter cloacae (extended-spectrum blactamase) infection from the joint and complete closure of the fistula was achieved by arthroscopic lavage under general anaesthesia repeated on 3 occasions, surgical debridement, ultrasound assisted wound therapy and vacuum assisted closure. Lavage of the wound with the vacuum assisted closure in place was facilitated via the novel VeraFlo instillation system consisting of specially designed therapeutic regulated accurate care pad tubing. The combination of these therapies resulted in resolution of the septic arthritis and fistula. Six weeks after admission the horse was discharged from the hospital with a completely healed wound and was not lame at a walk.
C1 [Rettig, M. J.; Lischer, C. J.] Free Univ Berlin, Fac Vet Med, Equine Clin, Berlin, Germany.
C3 Free University of Berlin
RP Rettig, MJ (通讯作者)，Free Univ Berlin, Fac Vet Med, Equine Clin, Berlin, Germany.
EM matthias.rettig@fu-berlin.de
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NR 28
TC 6
Z9 7
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0957-7734
EI 2042-3292
J9 EQUINE VET EDUC
JI Equine Vet. Educ.
PD JAN
PY 2017
VL 29
IS 1
BP 27
EP 32
DI 10.1111/eve.12390
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA EK1LU
UT WOS:000393687700006
DA 2026-07-24
ER
PT J
AU Wei, LY
   Zhang, HW
   Zhao, G
   Wang, GQ
   Yi, F
AF Wei Li-You
   Zhang Hong-Wei
   Zhao Gang
   Wang Guo-Qiang
   Yi Fan
TI Treatment of soft tissue defects in the heels of children in an
   emergency setting
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
LA English
DT Article
DE children; heel; reverse flow sural flap; soft tissue defect; vacuum
   sealing drainage
ID VACUUM-ASSISTED CLOSURE; BICYCLE-SPOKE INJURIES; FLAP
AB Reverse flow sural flap (RFSF) and vacuum sealing drainage (VSD) have been used to cover soft tissue defects in the heels of children in medical emergency settings. We report a retrospective case series, including a total of 19 children with soft tissue defects in heels resulting from spokes injury. In six patients, soft tissue defects in the heel were covered with RFSF. Further, in 13 patients, the defects were covered with VSD, in seven patients defects were repaired using free skin, and in six patients defects were repaired using RFSF after VSD. All wounds in the donor and recipient areas healed by first intention, and all free skins or island flaps completely survived; the color and luster on reconstructed areas were perfect. Patients were followed up for about 3-30 months, without osteomyelitis and infection in the heel, and the functions of the heel were satisfactory. RFSF and VSD were both advantageous, and were ideal for covering heel defects in children in emergency settings. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Wei Li-You; Zhao Gang; Wang Guo-Qiang; Yi Fan] Hebei United Univ, Affiliated Orthopaed Hosp, Hosp Tangshan 2, Dept Orthopaed, Tangshan, Peoples R China.
   [Zhang Hong-Wei] Hebei United Univ, Affiliated Orthopaed Hosp, Hosp Tangshan 2, Dept Intens Care Unit, Tangshan, Peoples R China.
C3 North China University of Science & Technology; North China University
   of Science & Technology
RP Zhang, HW (通讯作者)，Hebei United Univ, Affiliated Orthopaed Hosp, Hosp Tangshan 2, Dept Intens Care Unit, 21 Jian She Bei Rd, Tangshan City 063000, Peoples R China.
EM zhanghw200087@163.com
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 12
TC 2
Z9 3
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1060-152X
EI 1473-5865
J9 J PEDIATR ORTHOP B
JI J. Pediatr. Orthop.-Part B
PD MAR
PY 2017
VL 26
IS 2
BP 152
EP 158
DI 10.1097/BPB.0000000000000343
PG 7
WC Orthopedics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Pediatrics
GA EK2IM
UT WOS:000393751000009
PM 27258359
DA 2026-07-24
ER
PT J
AU Shou, KQ
   Niu, YH
   Zheng, X
   Ma, ZJ
   Jian, C
   Qi, BW
   Hu, X
   Yu, AX
AF Shou, Kangquan
   Niu, Yahui
   Zheng, Xun
   Ma, Zhanjun
   Jian, Chao
   Qi, Baiwen
   Hu, Xiang
   Yu, Aixi
TI Enhancement of Bone-Marrow-Derived Mesenchymal Stem Cell Angiogenic
   Capacity by NPWT for a Combinatorial Therapy to Promote Wound Healing
   with Large Defect
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; RANDOMIZED-TRIAL;
   TISSUE FORMATION; FULL-THICKNESS; DIFFERENTIATION; DRESSINGS
AB Poor viability of engrafted bone marrow mesenchymal stem cells (BMSCs) often hinders their application for wound healing, and the strategy of how to take full advantage of their angiogenic capacity within wounds still remains unclear. Negative pressure wound therapy (NPWT) has been demonstrated to be effective for enhancing wound healing, especially for the promotion of angiogenesis within wounds. Here we utilized combinatory strategy using the transplantation of BMSCs and NPWT to investigate whether this combinatory therapy could accelerate angiogenesis in wounds. In vitro, after 9-day culture, BMSCs proliferation significantly increased in NPWT group. Furthermore, NPWT induced their differentiation into the angiogenic related cells, which are indispensable for wound angiogenesis. In vivo, rat full-thickness cutaneous wounds treated with BMSCs combined with NPWT exhibited better viability of the cells and enhanced angiogenesis and maturation of functional blood vessels than did local BMSC injection or NPWT alone. Expression of angiogenesis markers (NG2, VEGF, CD31, and alpha-SMA) was upregulated in wounds treated with combined BMSCs with NPWT. Our data suggest that NPWT may act as an inductive role to enhance BMSCs angiogenic capacity and this combinatorial therapy may serve as a simple but efficient clinical solution for complex wounds with large defects.
C1 [Shou, Kangquan; Niu, Yahui; Zheng, Xun; Ma, Zhanjun; Jian, Chao; Qi, Baiwen; Hu, Xiang; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Hubei, Peoples R China.
EM yuaixi@whu.edu.cn
RI /E-6566-2018
FU National Natural Science Foundation of China [81572163]
FX This work was supported by Grants from the National Natural Science
   Foundation of China (Grant no. 81572163).
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NR 41
TC 22
Z9 26
U1 0
U2 18
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2017
VL 2017
AR 7920265
DI 10.1155/2017/7920265
PG 13
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA EK6FD
UT WOS:000394019500001
PM 28243602
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Chen, B
   Kao, HK
   Dong, ZQ
   Jiang, ZH
   Guo, LF
AF Chen, Bin
   Kao, Huang-Kai
   Dong, Ziqing
   Jiang, Zhaohua
   Guo, Lifei
TI Complementary Effects of Negative-Pressure Wound Therapy and Pulsed
   Radiofrequency Energy on Cutaneous Wound Healing in Diabetic Mice
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ELECTROMAGNETIC-FIELDS; MECHANISMS; SKIN;
   DEFORMATIONS; ULCERS; DEVICE; MODEL; FORM
AB Background: Negative-pressure wound therapy and pulsed radiofrequency energy are two clinical modalities used to treat soft-tissue wounds. They are purported to affect healing differently. The aim of this experimental study was to contrast the two modalities at a mechanistic level and to investigate whether their combined therapy could achieve additive and complementary effects on wound healing.
   Methods: Full-thickness dorsal cutaneous wounds of diabetic, db/db, mice were treated with either negative-pressure wound therapy, pulsed radiofrequency energy, or combined therapies. Macroscopic healing kinetics were examined. Epidermal regeneration (proliferation rate and length of reepithelialization) and neovascularization (blood vessel density) were investigated. Messenger RNA levels indicative of angiogenic (basic fibroblast growth factor), profibrotic (transforming growth factor-beta), epidermal proliferative (keratinocyte growth factor), and extracellular matrix remodeling (collagen 1) processes were measured in wound tissues.
   Results: All three treatment groups displayed faster wound healing. The negative-pressure wound therapy/pulsed radiofrequency energy combined therapy led to significantly faster healing than either the negative-pressure wound therapy or pulsed radiofrequency energy therapy alone. Epidermal regeneration and neovascularization were enhanced in all three groups. The two negative-pressure wound therapy groups (alone and combined with pulsed radiofrequency energy) demonstrated more significant increases in expression of all assayed growth factors than the pulsed radiofrequency energy group. Furthermore, the combined therapy exhibited a more profound elevation in collagen 1 expression than either of the two therapies alone.
   Conclusion: Combining the negative-pressure wound therapy and pulsed radiofrequency energy modalities can achieve additive benefits in cutaneous healing, and the two therapies can be easily used together to complement each other in clinical wound treatments.
C1 [Guo, Lifei] Lahey Hosp & Med Ctr, Dept Plast Surg, 41 Mall Rd,6W, Burlington, MA 01805 USA.
   Chang Gung Univ, Dept Plast & Reconstruct Surg, Chang Gung Mem Hosp, Taoyuan, Taiwan.
   Southern Med Univ, Dept Plast & Cosmet Surg, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China.
   Shanghai Ninth Peoples Hosp, Dept Plast & Reconstruct Surg, Shanghai, Peoples R China.
C3 Lahey Hospital & Medical Center; Chang Gung University; Chang Gung
   Memorial Hospital; Southern Medical University - China; Shanghai Jiao
   Tong University
RP Guo, LF (通讯作者)，Lahey Hosp & Med Ctr, Dept Plast Surg, 41 Mall Rd,6W, Burlington, MA 01805 USA.; Jiang, ZH (通讯作者)，Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Shanghai, Peoples R China.
EM zhhjiang@hotmail.com; lifei.guo@lahey.org
RI ; /AAG-3449-2019
OI Chen, Bin/0000-0002-7606-1382; Guo, Lifei/0000-0003-2019-0086; 
FU Regenesis Biomedical, Inc. (Scottsdale, Ariz.); Robert E. Weiss
   Foundation (Burlington, Mass.)
FX This study was funded through a grant to Lahey Hospital & Medical Center
   by Regenesis Biomedical, Inc. (Scottsdale, Ariz.), and the Robert E.
   Weiss Foundation (Burlington, Mass.).
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NR 48
TC 18
Z9 19
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2017
VL 139
IS 1
BP 105
EP 117
DI 10.1097/PRS.0000000000002909
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EK6RF
UT WOS:000394051100006
PM 28027236
DA 2026-07-24
ER
PT J
AU Wiegering, A
   Dietz, UA
   Corteville, C
   Plassmeier, L
   Jurowich, C
   Germer, CT
   Krajinovic, K
AF Wiegering, Armin
   Dietz, Ulrich A.
   Corteville, Caroline
   Plassmeier, Lars
   Jurowich, Christian
   Germer, Christoph-Thomas
   Krajinovic, Katica
TI Impact of incisional negative pressure wound therapy on perineal wound
   healing after abdominoperineal rectum extirpation
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Negative pressure wound therapy; Colorectal cancer; Rectum extirpation
ID INFECTIONS; PREVENTION
AB Perineal wound healing disorders are one of the major complications following abdominoperineal rectum extirpation.
   We evaluated the impact of an "incisional negative pressure wound therapy" (iNPWT) system after abdominoperineal rectum extirpation in six patients. All patients had a neoadjuvant radiochemotherapy with 50.4 Gy and 5-FU. Five of the six patients (83%) experienced complication-free healing of the perineal wound after 5 to 12 days of iNPWT. One patient developed a wound healing disorder 8 days after abdominoperineal rectum extirpation during current iNPWT.
   Use of an iNPWT system can be of favor after abominoperineal rectum extirpation.
C1 [Wiegering, Armin; Dietz, Ulrich A.; Corteville, Caroline; Plassmeier, Lars; Jurowich, Christian; Germer, Christoph-Thomas; Krajinovic, Katica] Univ Wurzburg, Julius Maximilians Univ, Univ Hosp, Dept Gen Visceral Vasc & Pediat Surg, Oberduerrbacherstr 6, D-97080 Wurzburg, Germany.
   [Wiegering, Armin] Univ Wurzburg, Dept Biochem & Mol Biol, D-97074 Wurzburg, Germany.
   [Germer, Christoph-Thomas] Univ Wurzburg, Univ Hosp, Comprehens Canc Ctr Mainfranken, Josef Schneiderstr 6, D-97080 Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg; University of Wurzburg
RP Wiegering, A; Krajinovic, K (通讯作者)，Univ Wurzburg, Julius Maximilians Univ, Univ Hosp, Dept Gen Visceral Vasc & Pediat Surg, Oberduerrbacherstr 6, D-97080 Wurzburg, Germany.; Wiegering, A (通讯作者)，Univ Wurzburg, Dept Biochem & Mol Biol, D-97074 Wurzburg, Germany.
EM wiegering_a@ukw.de; krajinovic_k@ukw.de
RI Wiegering, Armin/X-7541-2018; Jurowich, Christian/JLL-2410-2023
CR Blackham AU, 2013, AM J SURG, V205, P647, DOI 10.1016/j.amjsurg.2012.06.007
   Dohmen PM, 2014, MED SCI MONITOR, V20, P1814, DOI 10.12659/MSM.891169
   Grauhan O, 2013, J THORAC CARDIOV SUR, V145, P1387, DOI 10.1016/j.jtcvs.2012.09.040
   Horch RE, 2015, J WOUND CARE, V24, P21, DOI 10.12968/jowc.2015.24.Sup4b.21
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   Soares KC, 2015, AM J SURG, V209, P324, DOI 10.1016/j.amjsurg.2014.06.022
NR 6
TC 13
Z9 15
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD FEB
PY 2017
VL 32
IS 2
BP 291
EP 293
DI 10.1007/s00384-016-2704-5
PG 3
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA EK8FO
UT WOS:000394159500017
PM 27844201
DA 2026-07-24
ER
PT J
AU Li, JB
   Pan, ZJ
   Yan, SG
   Zhao, X
AF Li, Jianbin
   Pan, Zhijun
   Yan, Shigui
   Zhao, Xiang
TI Single-cortex is better than double-cortex in fibula grafts for large
   tibia bone defect in a 2-year-old child A case report of a successful
   surgery and discussion of bone graft choices
SO MEDICINE
LA English
DT Article
DE bone defect; case report; fibular graft; infant
ID INDUCED-MEMBRANE TECHNIQUE; RECONSTRUCTION; RESECTION
AB Background: Large bone defect in infant or small patients has been little reported and the management of such a patient is difficult. Considering the little knowledge of this area, we present this special case of a successful single-cortex fibula graft for the treatment of a large tibia bone defect in a 2-year-old patient to share our experience.
   Casesummary: A 2-year-old male patient presented to our hospital with history of leg pain for 4 months. According to his medical records, he was involved in a traffic accident and diagnosed with open tibia fracture. A previous surgery of emergent debridement and external fixation was performed in our institution, leaving a 6-cm tibia bone defect. After that this patient received several times of vacuum sealing drainage (VSD), skin grafting, and changed external fixation to cast because of pin tract infection.
   The physical examination of the patient showed a healed skin wound and a good dorsal arterial pulse. X-ray indicated a large bone defect at the tibia fracture site with osteosclerosis at the fracture sections. This patient received ipsilateral single-cortex vascularized single-cortex fibula graft, other than double-cortex fibula graft. X-ray and CT scan 4 months after the operation confined bone healing. The patient returned to normal activities with an inconspicuous limb.
   Conclusion: Ipsilateral single-cortex fibula graft is effective for the treatment of large tibia bone defect in infant or small aged patients. It exhibited better potential benefits than double-cortex graft in such cases.
C1 [Li, Jianbin; Pan, Zhijun; Yan, Shigui; Zhao, Xiang] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthopaed Surg, Hangzhou 310000, Zhejiang, Peoples R China.
   [Li, Jianbin; Pan, Zhijun; Yan, Shigui; Zhao, Xiang] Zhejiang Univ, Inst Orthopaed Res, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Zhao, X (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthopaed Surg, Hangzhou 310000, Zhejiang, Peoples R China.
EM flyingzhao@zju.edu.cn
RI Pan, Zhijun/AAD-6547-2022
FU National Natural Science Foundation of China [81401785, 81371954]
FX All phases of this study are supported by National Natural Science
   Foundation of China (81401785 and 81371954).
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NR 16
TC 1
Z9 1
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB
PY 2017
VL 96
IS 5
AR e5965
DI 10.1097/MD.0000000000005965
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EK9OM
UT WOS:000394253800038
PM 28151885
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Accurso, A
   Rocco, N
   Accardo, G
   Reale, P
   Salerno, C
   Mattera, E
   D'Andrea, F
AF Accurso, Antonello
   Rocco, Nicola
   Accardo, Giuseppe
   Reale, Paola
   Salerno, Carmela
   Mattera, Edi
   D'Andrea, Francesco
TI Innovative Management of Implant Exposure in ADM/Implant-Based Breast
   Reconstruction with Negative Pressure Wound Therapy
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Breast reconstruction; A cellular dermal matrix; Negative pressure wound
   therapy; Implant exposure
ID ACELLULAR DERMAL MATRIX; SURGERY; ALLODERM; MESH
AB One-stage implant-based breast reconstruction has been recently improved by the introduction of biological [acellular dermal matrix (ADM)] and synthetic meshes. Advantages of ADMs in implant-based breast reconstruction derive from the expansion of the space available for the direct positioning of an implant, but their use could be associated with several complications. Although the majority of complications can be easily managed, mistakes in dealing with the first clinical signs of a potential adverse event can lead to implant loss.
   We report a case of ADM/implant exposure following NAC-sparing mastectomy and immediate implant-based reconstruction, successfully managed with an innovative staged treatment using negative pressure wound therapy, which allowed a rapid re-positioning of the prosthesis after complete clearance of bacteria from the implant pocket.
   The safest strategy to manage implant exposure and concomitant bacterial growth is reported to be implant removal and delayed re-positioning after several months, following prolonged targeted antibiotic therapy. Our case shows how a short-time implant re-positioning following implant removal for implant exposure could be successfully pursued thanks to the shrewd use of negative pressure wound therapy with great advantages in terms of patient satisfaction and post-operative quality of life, offering women experiencing this complication the option of not delaying reconstruction for months after resolution of the complication, potentially avoiding major surgical procedures such as autologous tissue reconstructions.
C1 [Accurso, Antonello; Accardo, Giuseppe; Reale, Paola; Salerno, Carmela] Univ Hosp Federico II, Dept Surg, Breast Unit, Naples, Italy.
   [Rocco, Nicola] Univ Naples Federico II, Dept Clin Med & Surg, Via S Pansini 5, I-80131 Naples, Italy.
   [Mattera, Edi] Univ Naples 2, Dept Clin & Expt Med Flaviano Magrassi, Clin Med Hosp Unit, Ambulatory Vulnol, Naples, Italy.
   [D'Andrea, Francesco] Univ Naples Federico II, Dept Plast & Reconstruct Surg, Naples, Italy.
C3 University of Naples Federico II; Universita della Campania Vanvitelli;
   University of Naples Federico II
RP Rocco, N (通讯作者)，Univ Naples Federico II, Dept Clin Med & Surg, Via S Pansini 5, I-80131 Naples, Italy.
EM nicolarocco2003@gmail.com
OI Rocco, Nicola/0000-0001-6941-7873
CR Becker S, 2009, PLAST RECONSTR SURG, V123, P1, DOI 10.1097/PRS.0b013e3181904bff
   Citron I, 2016, GMS INTERDISCIP PLAS, V5, DOI 10.3205/iprs000085
   Cordeiro PG, 2008, NEW ENGL J MED, V359, P1590, DOI 10.1056/NEJMct0802899
   Ellis HL, 2016, WORLD J SURG ONCOL, V14, DOI 10.1186/s12957-016-0874-9
   Forsberg CG, 2014, ANN PLAS SURG, V72, pS116, DOI 10.1097/SAP.0000000000000098
   Hartzell TL, 2010, PLAST RECONSTR SURG, V126, P1711, DOI 10.1097/PRS.0b013e3181ef900c
   Israeli R, 2012, PLAST RECONSTR SURG, V130, p159S, DOI 10.1097/PRS.0b013e3182634e62
   Jacobs JMS, 2015, BRIT J HOSP MED, V76, P211, DOI 10.12968/hmed.2015.76.4.211
   Liao EC, 2007, ANN PLAS SURG, V59, P218, DOI 10.1097/SAP.0b013e31802c148c
   Spear SL, 2004, PLAST RECONSTR SURG, V113, P1634, DOI 10.1097/01.PRS.0000117194.21748.02
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NR 11
TC 17
Z9 19
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD FEB
PY 2017
VL 41
IS 1
BP 36
EP 39
DI 10.1007/s00266-016-0739-1
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EL2DL
UT WOS:000394430200006
PM 28032164
DA 2026-07-24
ER
PT J
AU Shin, JY
   Roh, SG
   Lee, NH
   Yang, KM
AF Shin, Jin Yong
   Roh, Si-Gyun
   Lee, Nae-Ho
   Yang, Kyung-Moo
TI Negative Pressure Wound Therapy as Effective and Comfortable Management
   After Treatment of Osmidrosis
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Osmidrosis; Postoperative management
ID AXILLARY OSMIDROSIS; SURGICAL-TREATMENT; SKIN-GRAFTS; CURETTAGE
AB Although osmidrosis has been widely discussed in respect to its treatment modalities, there has been no definite consideration of postoperative management after the treatment of osmidrosis. We have tested the 40-125 mmHg range of negative pressure. We present negative pressure wound therapy (NPWT) of 70 mmHg for postoperative management in osmidrosis because NPWT has a role in removing fluid, such as blood or seroma, and diminishing the dead space between the skin and subcutaneous tissue. Patients who receive NPWT have shown successful treatment outcomes and no skin necrosis or hematoma formation. Additionally, NPWT could improve postoperative daily activity compared with conventional compressive dressings.
C1 [Shin, Jin Yong; Roh, Si-Gyun; Lee, Nae-Ho; Yang, Kyung-Moo] Chonbuk Natl Univ Hosp, Dept Plast & Reconstruct Surg, 20 Geonji Ro, Jeonju Si 561712, Chonbuk, South Korea.
C3 Jeonbuk National University; Jeonbuk National University Hospital
RP Roh, SG (通讯作者)，Chonbuk Natl Univ Hosp, Dept Plast & Reconstruct Surg, 20 Geonji Ro, Jeonju Si 561712, Chonbuk, South Korea.
EM pssroh@jbnu.ac.kr
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NR 10
TC 4
Z9 5
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD FEB
PY 2017
VL 41
IS 1
BP 121
EP 125
DI 10.1007/s00266-016-0726-6
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EL2DL
UT WOS:000394430200019
PM 28032154
DA 2026-07-24
ER
PT J
AU Reinisch, A
   Liese, J
   Woeste, G
   Bechstein, W
   Habbe, N
AF Reinisch, Alexander
   Liese, Juliane
   Woeste, Guido
   Bechstein, Wolf
   Habbe, Nils
TI A Retrospective, Observational Study of Enteral Nutrition in Patients
   with Enteroatmospheric Fistulas
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case reports; postoperative complication; fistula; enteral feeding;
   nutritional status
ID HOME PARENTERAL-NUTRITION; SHORT-BOWEL SYNDROME; OPEN ABDOMEN;
   ENTEROCUTANEOUS FISTULAS; MANAGEMENT; TRAUMA; COMPLICATIONS; EXPERIENCE;
   OUTCOMES; SUPPORT
AB Enteroatmospheric fistulas (EAFs) represent a challenging problem in patients with an open abdomen (OA). A retrospective, descriptive study was conducted to evaluate the effects of enteral alimentation on wound status and management and nutrition. All patients with an EAF in an OA treated between October 2012 and December 2014 at a university hospital in Germany were included without criteria for exclusions. Demographic and morbidity-related data collected included age, gender, surgeries, OA grading, body mass index (BMI), serum albumin, and serum creatinin. Underlying diseases and time between the index operation and the formation of the OA and EAFs were analyzed in relation to the initiation of enteral nutrition (EN), which can aggravate and contaminate the OA due to intestinal secretions necessary for digestion. The OA was described in size and area of the fascia defect and classified according to the Bjrck Scale. The number and location of the fistulas and the duration of negative pressure wound therapy (NPWT) were documented. Outcome parameters included fistula volume, wound management (eg, dressing change frequency, need for wound revision), feeding tolerance, systemic impact of nutrition, nutrition status at discharge, and mortality. Data were analyzed using primary descriptive statistics. The Mann-Whitney test was used to evaluate changes in fistula volume and BMI; categorical data were compared using Fisher's exact test. A P value < 0.05 was considered significant. Ten (10) patients (8 women, median age of participants 55.4 [range 44-71] years) were treated during the study time period. Seven (7) patients had the first fistula orifice in the upper jejunum (UJF); 8 had more than 1 fistula. EN was initiated with high caloric liquid nutrition and gradually increased to a 25 kcal/kg/day liquid or solid nutrition. All patients were provided NPWT at 75 mm Hg to 100 mm Hg. EN was not followed by a significant increase of median daily fistula volume (1880 mL versus 2520 mL, P = 0.25) or the need for more frequent changes of NPWT dressings (days between changes 2.6 versus 2.9, P = 0.19). In 9 patients, the severity of wound complications such as inflammation or skin erosion decreased both in frequency and magnitude (eg, affected area). All patients achieved a sufficient oral intake, but only 3 were discharged from the hospital without parenteral nutrition. In this study, EN did not cause additional problems in wound management but did not provide sufficient alimentation in patients with a UJF. Prospective studies are needed to clarify associations between EN, nutrition, and wound management.
C1 [Reinisch, Alexander; Liese, Juliane; Woeste, Guido; Bechstein, Wolf; Habbe, Nils] Univ Hosp & Clin Frankfurt Main, Dept Gen & Visceral Surg, Frankfurt, Hassia, Germany.
RP Reinisch, A (通讯作者)，Univ Hosp & Clin Frankfurt Main, Gen & Visceral Surg, Theodor Stern Kai 7, D-60590 Frankfurt, Hassia, Germany.
EM alexander.reinisch@kgu.de
RI Reinisch, Alexander/AAP-6813-2021; Bechstein, Wolf/H-5457-2019; Liese,
   Juliane/J-6547-2017; /AAA-9828-2021
OI Reinisch, Alexander/0000-0002-5233-0648; Bechstein,
   Wolf/0000-0002-3267-8145; Liese, Juliane/0000-0003-1547-1334; 
CR Amiot A, 2013, CLIN NUTR, V32, P368, DOI 10.1016/j.clnu.2012.08.007
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   Blaser AR, 2015, CLIN NUTR, V34, P956, DOI 10.1016/j.clnu.2014.10.006
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   Miller RS, 2005, J TRAUMA, V59, P1365, DOI 10.1097/01.ta.0000196004.49422.af
   Schecter WP, 2011, SURG CLIN N AM, V91, P481, DOI 10.1016/j.suc.2011.02.004
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   Subramaniam MH, 2002, J TRAUMA, V53, P386, DOI 10.1097/00005373-200208000-00037
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NR 31
TC 9
Z9 11
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUL
PY 2016
VL 62
IS 7
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EL3DY
UT WOS:000394501000002
PM 27428564
DA 2026-07-24
ER
PT J
AU Dettmers, R
   Brekelmans, W
   Leijnen, M
   van der Burg, BB
   Ritchie, E
AF Dettmers, Robert
   Brekelmans, Wouter
   Leijnen, Michiel
   van der Burg, Boudewijn Borger
   Ritchie, Ewan
TI Negative Pressure Wound Therapy With Instillation and Dwell Time Used to
   Treat Infected Orthopedic Implants: A 4-patient Case Series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case study; wound infection; osteosynthesis; fracture; negative pressure
   wound therapy
ID VACUUM-ASSISTED CLOSURE; FRACTURES; IMPACT
AB Infection following orthopedic implants for bone fixation or joint replacement is always serious and may require removal of the osteosynthetic material. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) is an emerging therapy for the treatment of complex wounds, including infected wounds with osteosynthetic material. The purpose of this case study was to evaluate the outcomes of 4 patients (1 man, 3 women; age range 49 to 71 years) with a postoperative wound infection (POWI) following fracture repair and internal fixation. All patients were at high risk for surgical complications, including infections. Standard infection treatments (antibiotics) had been unsuccessful. Based on the available literature, a NPWTi-d protocol was developed. Following surgical debridement, wounds were instilled with polyhexanide biguanide with a set dwell time of 15 minutes, followed by continuous NPWTi-d of -125 mm Hg for 4 hours. The system was changed every 3 to 4 days until sufficient granulation tissue was evident and negative pressure without instillation could be used. Systemic antibiotics were continued in all patients. Granulation tissue was found to be sufficient in 12 to 35 days in the 4 cases, no recurrence of infection was noted, and the osteosynthesis material remained in place. No adverse events were observed. Research is needed to compare the safety and effectiveness of this adjunct treatment in the management of challenging wounds to other patient and wound management approaches.
C1 [Dettmers, Robert] Alrijne Hosp Leiderdorp, Trauma Surg, Leiderdorp, Netherlands.
   [Dettmers, Robert] Alrijne Hosp Leiderdorp, Wound Care, Leiderdorp, Netherlands.
   [Brekelmans, Wouter; Leijnen, Michiel; van der Burg, Boudewijn Borger; Ritchie, Ewan] Alrijne Hosp Leiderdorp, Leiderdorp, Netherlands.
RP Dettmers, R (通讯作者)，Alrijne Hosp Leiderdorp, Dept Gen Surg, Simon Smitweg 1, NL-2353 GA Leiderdorp, Netherlands.
EM R.C.dettmers@lumc.nl
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NR 20
TC 12
Z9 15
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD SEP
PY 2016
VL 62
IS 9
BP 30
EP 40
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EL3FJ
UT WOS:000394504700003
PM 27668478
DA 2026-07-24
ER
PT J
AU Mannino, BJ
   Pullen, MW
   Gaines, R
AF Mannino, Brian J.
   Pullen, Michael W.
   Gaines, Robert
TI Preventing Seal Leak During Negative Pressure Wound Therapy Near
   External Fixators: A Technical Tip
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure; seal leak; external fixator
ID VACUUM-ASSISTED CLOSURE; FIXATION DEVICE
AB Negative pressure wound therapy is an effective tool for the treatment of open wounds. Occasionally these wounds are associated with injuries or procedures that require treatment with an external fixator. This article shows how a simple, inexpensive, and commercially available product can be used to prevent loss of suction around external fixator pins within the negative pressure wound treatment area.
C1 [Mannino, Brian J.; Pullen, Michael W.; Gaines, Robert] Naval Med Ctr Portsmouth, Dept Orthopaed Surg, Portsmouth, VA USA.
C3 United States Department of Defense; United States Navy
RP Mannino, BJ (通讯作者)，Naval Med Ctr Portsmouth, Portsmouth, VA 23708 USA.
EM brian.j.mannino.mil@mail.mil
RI ; Mannino, Brian/ABA-2921-2021
OI Pullen, William/0000-0001-7775-8766; Mannino, Brian/0000-0002-3116-090X
CR Aydogdu IO, 2013, J HAND SURG-AM, V38A, P2520, DOI 10.1016/j.jhsa.2013.09.037
   Bulla A, 2014, J ORTHOP TRAUMA, V28, pE176, DOI 10.1097/BOT.0000000000000013
   de Laat EHEW, 2011, ANN PLAS SURG, V67, P626, DOI 10.1097/SAP.0b013e31820b3ac1
   Egemen O, 2011, INT WOUND J, V8, P428, DOI 10.1111/j.1742-481X.2011.00804.x
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   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Suissa D, 2011, PLAST RECONSTR SURG, V128, p498E, DOI 10.1097/PRS.0b013e31822b675c
NR 7
TC 2
Z9 2
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD MAR
PY 2017
VL 31
IS 3
BP E101
EP E102
DI 10.1097/BOT.0000000000000709
PG 2
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA EL3KO
UT WOS:000394518200016
PM 28222052
DA 2026-07-24
ER
PT J
AU Siang, KCC
   Fauzi, AA
   Hasnan, N
AF Siang, Kelvin Cheng Chek
   Fauzi, Aishah Ahmad
   Hasnan, Nazirah
TI Diagnostic dilemma of sacral abscess presented with seizure and altered
   conscious level in a patient with spinal cord injury
SO JOURNAL OF SPINAL CORD MEDICINE
LA English
DT Article
DE Sacral abscess; Septicaemia; Pressure ulcer; Spinal cord injury
ID PRESSURE ULCERS
AB Context: Infection and septicaemia may clinically presented with seizure and altered conscious level. In spinal cord injury (SCI) population, they are at risk of having pressure ulcer which can be complicated further with infection and septicaemia.
   Findings: A 40-year-old man with complete T4 SCI and multiple clean and non-healing pressure ulcers at sacral and bilateral ischial tuberosity regions was initially admitted for negative pressure wound therapy (NPWT) dressing. He had an episode of seizure and subsequently had fluctuating altered conscious level before the diagnosis of deep-seated sacral abscess was made and managed. Prior investigations to rule out common possible sources of infections and management did not resolve the fluctuating event of altered consciousness.
C1 [Siang, Kelvin Cheng Chek; Fauzi, Aishah Ahmad; Hasnan, Nazirah] Univ Malaya, Dept Rehabil, Fac Med, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya
RP Fauzi, AA (通讯作者)，Univ Malaya, Dept Rehabil, Fac Med, Kuala Lumpur 50603, Malaysia.
EM aishah_fauzi@um.edu.my
RI Hasnan, Nazirah/M-5081-2017; /B-8194-2010
OI Hasnan, Nazirah/0000-0002-5775-428X; 
CR Hauptfleisch J, 2013, ARCH PHYS MED REHAB, V94, P1107, DOI 10.1016/j.apmr.2012.11.012
   Honigman L, 2012, J EMERG MED, V42, P569, DOI 10.1016/j.jemermed.2011.07.033
   Montgomerie JZ, 1997, CLIN INFECT DIS, V25, P1285, DOI 10.1086/516144
   Ruan CM, 1998, ARCH PHYS MED REHAB, V79, P1080, DOI 10.1016/S0003-9993(98)90175-7
   Simpson MA, 2009, J CLIN NEUROSCI, V16, P1682, DOI 10.1016/j.jocn.2009.03.040
NR 5
TC 1
Z9 1
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1079-0268
EI 2045-7723
J9 J SPINAL CORD MED
JI J. Spinal Cord. Med.
PY 2017
VL 40
IS 1
BP 113
EP 117
DI 10.1080/10790268.2015.1133016
PG 5
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EL5FX
UT WOS:000394648100017
PM 26871508
DA 2026-07-24
ER
PT J
AU Sandy-Hodgetts, K
   Leslie, GD
   Parsons, R
   Zeps, N
   Carville, K
AF Sandy-Hodgetts, K.
   Leslie, G. D.
   Parsons, R.
   Zeps, N.
   Carville, K.
TI Prevention of postsurgical wound dehiscence after abdominal surgery with
   NPWT: a multicentre randomised controlled trial protocol
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE surgical wound dehiscence; efficacy; negative pressure wound therapy;
   randomised controlled trial; economic cost analysis
ID THERAPY
AB Objective: The effectiveness of negative pressure wound therapy (NPWT) in the prevention of postoperative surgical wound dehiscence (SWD) is the subject of much debate and remains to be determined. This study will identify individuals at risk of postoperative SWD and trial the use of NPWT as a prophylactic measure against the occurrence of SWD, compared with a nonNPWT standard surgical dressing (SSD).
   Method: A prospective multicentre randomised controlled trial comparing NPWT dressing against standard surgical dressings (SSD) will be conducted. An intention-to-treat (ITT) approach will be used for the trial.
   Aims: The primary outcome is the prevention of postoperative SWD up to and including day 30 postoperative. Secondary outcomes are: prevention of surgical site infection (SSI) and economic analysis of treatment groups.
   Conclusion: This study will determine the effectiveness of NPWT in the prevention of postoperative abdominal SWD in a predefined level of risk population. This level 1 study will provide further data for abdominal SWD risk classification, which is anticipated to inform preventive postoperative management. The study design uses a prospective real-world scenario in order to identify clinically significant differences between the intervention and control groups.
C1 [Sandy-Hodgetts, K.; Leslie, G. D.] Curtin Univ, Sch Nursing & Midwifery, Perth, WA, Australia.
   [Sandy-Hodgetts, K.] Univ Western Australia, Sch Anat Physiol & Human Biol, Perth, WA, Australia.
   [Sandy-Hodgetts, K.; Leslie, G. D.; Carville, K.] Wound Management Innovat Cooperat Res Ctr, West End, Qld, Australia.
   [Parsons, R.] Curtin Univ, Sch Occupat Therapy & Social Work, Perth, WA, Australia.
   [Parsons, R.] Curtin Univ, Sch Pharm, Perth, WA, Australia.
   [Zeps, N.] Curtin Univ, Sch Hlth Sci, Perth, WA, Australia.
   [Zeps, N.] Murdoch Univ, Ctr Comparat Genom, Perth, WA, Australia.
   [Zeps, N.] Univ Western Australia, Sch Pathol & Lab Med, Perth, WA, Australia.
   [Zeps, N.] Univ Western Australia, Colorectal Canc Res Unit, Perth, WA, Australia.
   [Zeps, N.] Univ Notre Dame Australia, Sch Med, Fremantle, WA, Australia.
   [Carville, K.] Silver Chain Grp, Fremantle, WA, Australia.
C3 Curtin University; University of Western Australia; Curtin University;
   Curtin University; Curtin University; Murdoch University; University of
   Western Australia; University of Western Australia; The University of
   Notre Dame Australia
RP Sandy-Hodgetts, K (通讯作者)，Curtin Univ, Sch Nursing & Midwifery, Perth, WA, Australia.; Sandy-Hodgetts, K (通讯作者)，Univ Western Australia, Sch Anat Physiol & Human Biol, Perth, WA, Australia.; Sandy-Hodgetts, K (通讯作者)，Wound Management Innovat Cooperat Res Ctr, West End, Qld, Australia.
EM Kylie.Sandy-Hodgetts@curtin.edu.au
RI Zeps, Nikolajs/AAF-3186-2021; Sandy-Hodgetts, Kylie/A-7494-2019
OI Zeps, Nikolajs/0000-0002-6404-6839; Sandy-Hodgetts,
   Kylie/0000-0001-6848-2526
FU Wound Management Innovation CRC (WMICRC) Project Grant [3.30]
FX This study is funded by the Wound Management Innovation CRC (WMICRC)
   Project Grant 3.30 and devices are being donated to the study by product
   supplier Smith & Nephew.
CR [Anonymous], TXB SURG
   [Anonymous], MOSBYS MED DICT
   [Anonymous], AUSTR HOSP STAT 2010
   [Anonymous], MED J AUST
   [Anonymous], EFFECTIVENESS NEGATI
   [Anonymous], J WOUND CARE
   [Anonymous], CDC NHSN SURVEILLANC
   Baronski S., 2008, Wound Care Essentials Principles and Practice
   Husereau D, 2013, VALUE HEALTH, V16, P231, DOI 10.1016/j.jval.2013.02.002
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   Leaper D, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1924
   Leaper David J, 2004, Int Wound J, V1, P247, DOI 10.1111/j.1742-4801.2004.00067.x
   McLaws ML, 2003, J HOSP INFECT, V53, P259, DOI 10.1053/jhin.2002.1361
   Ousey KJ, 2013, SPINE J, V13, P1393, DOI 10.1016/j.spinee.2013.06.040
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   Xie X, 2010, J WOUND CARE, V19, P488
NR 28
TC 7
Z9 11
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2017
VL 26
IS 2
SU S
BP S23
EP S26
DI 10.12968/jowc.2017.26.Sup2.S23
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EM8HO
UT WOS:000395552300004
PM 28182535
DA 2026-07-24
ER
PT J
AU Raimond, E
   Pelissier, A
   Emeriau, ME
   François, C
   Graesslin, O
AF Raimond, E.
   Pelissier, A.
   Emeriau, M. Etienette
   Francois, C.
   Graesslin, O.
TI Use of negative pressure wound therapy after vulvar carcinoma: case
   studies
SO JOURNAL OF WOUND CARE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; MANAGEMENT; TRENDS
AB Surgery is widely used to treat vulvar cancer. However, postoperative complications after a vulvectomy can occur in 26-85% of the cases. Here, the authors describe a complete radical vulvectomy with bilateral inguinal lymph node dissection performed in two patients. Both patients developed infection and wound breakdown postoperatively. Due to failure of local care, negative pressure wound therapy (NPWT) was started to reduce bacterial rates and tension on wound edges. Accelerated tissue healing was observed in both cases, as well as an improvement in the patients' quality of life.
C1 [Raimond, E.; Pelissier, A.; Emeriau, M. Etienette; Graesslin, O.] Reims Champagne Ardennes Univ, Maison Blanche Hosp, Dept Obstet & Gynaecol, Reims, France.
   [Francois, C.] Reims Champagne Ardennes Univ, Maison Blanche Hosp, Dept Plast & Reconstruct Surg, Reims, France.
C3 CHU de Reims; Universite de Reims Champagne-Ardenne; Universite de Reims
   Champagne-Ardenne; CHU de Reims
RP Raimond, E (通讯作者)，Reims Champagne Ardennes Univ, Maison Blanche Hosp, Dept Obstet & Gynaecol, Reims, France.
EM eraimond@chu-reims.fr
OI FRANCOIS, Caroline/0000-0002-8323-1554
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Argenta PA, 2002, OBSTET GYNECOL, V99, P497, DOI 10.1016/S0029-7844(01)01752-5
   Borget I, 2011, VACCINE, V29, P5245, DOI 10.1016/j.vaccine.2011.05.018
   CAVANAGH D, 1990, AM J OBSTET GYNECOL, V163, P1007, DOI 10.1016/0002-9378(90)91114-R
   Gaarenstroom KN, 2003, INT J GYNECOL CANCER, V13, P522, DOI 10.1046/j.1525-1438.2003.13304.x
   Hughes W.T., 1999, HOSP EPIDEMIOLOGY IN
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Piwonka M A, 1999, J Wound Ostomy Continence Nurs, V26, P298, DOI 10.1016/S1071-5754(99)90065-7
   Senn B, 2010, INT J GYNECOL CANCER, V20, P646, DOI 10.1111/IGC.0b013e3181d92723
   STURGEON SR, 1992, AM J OBSTET GYNECOL, V166, P1482, DOI 10.1016/0002-9378(92)91623-I
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NR 11
TC 5
Z9 6
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2017
VL 26
IS 2
BP 72
EP 74
DI 10.12968/jowc.2017.26.2.72
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EM9SK
UT WOS:000395651200005
PM 28182520
DA 2026-07-24
ER
PT J
AU Hsiao, SFY
   Ma, H
   Wang, YH
   Wang, TH
AF Hsiao, Sara Fu-yin
   Ma, Hsu
   Wang, Yu-Hei
   Wang, Tien-Hsiang
TI Occlusive drainage system for split-thickness skin graft: A prospective
   randomized controlled trial
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy; Occlusive drainage system;
   Split-thickness skin graft; Wound care; Wound dressing
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; DRESSINGS; LAYER; PAIN
AB Background: Split-thickness skin grafts are widely used in reconstruction of large area defects. Conventional postoperative recipient site care includes saline-moistened gauze with a protective layer of petroleum gauze and splints for immobilization. This method causes pain while changing the dressing. We designed a better occlusive drainage system for split thickness skin grafts. We compared the treatment effect and subjective evaluation of our occlusive drainage system with that of the conventional method for coverage of split-thickness skin grafts.
   Methods: A randomized controlled trial was carried out in patients who received split thickness skin grafts. Patients aged 24-76 years were randomly assigned to the occlusive drainage system or the conventional indirect wet dressing method. The status of graft take, pain, and subjective evaluations were compared.
   Results: Twenty-eight participants were enrolled, with 14 in each group. The percentage of graft take was no difference between the 2 groups. No wound infection developed. Patients in the occlusive drainage system group experienced less pain and greater satisfaction. All patients followed up for at least 3 months, and no hypertrophic scar formation was noted.
   Conclusion: Comparing with the indirect wet dressing method, this new method is practical for covering split-thickness skin grafts, causes less pain, and provides a better experience for patients. (C) 2016 Elsevier Ltd and ISBI. All rights reserved.
C1 [Hsiao, Sara Fu-yin; Ma, Hsu; Wang, Tien-Hsiang] Taipei Vet Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, 19-F,201,Sec 2,Shipai Rd, Taipei 11217, Taiwan.
   [Hsiao, Sara Fu-yin; Ma, Hsu; Wang, Tien-Hsiang] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan.
   [Wang, Yu-Hei] Taipei Vet Gen Hosp, Dept Nursing, Taipei, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; Taipei Veterans General Hospital
RP Wang, TH (通讯作者)，Taipei Vet Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, 19-F,201,Sec 2,Shipai Rd, Taipei 11217, Taiwan.
EM wangts@vghtpe.gov.tw
RI Wang, Tien-Hsiang/AAJ-4677-2020
FU Taipei Veterans General Hospital [VGH-102-C-153]; Veterans General
   Hospital-National Yang-Ming University Excellent Physician Scientists
   Cultivation Program [103-V-B-063]
FX This work was supported by the Taipei Veterans General Hospital
   (VGH-102-C-153) and Taipei Veterans General Hospital-National Yang-Ming
   University Excellent Physician Scientists Cultivation Program, No.
   103-V-B-063.
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NR 21
TC 18
Z9 19
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAR
PY 2017
VL 43
IS 2
BP 379
EP 387
DI 10.1016/j.burns.2016.08.025
PG 9
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA EN2LI
UT WOS:000395841300018
PM 28341261
DA 2026-07-24
ER
PT J
AU Nemeth, N
   Peto, K
   Deak, A
   Sogor, V
   Varga, G
   Tanczos, B
   Balog, K
   Csiszko, A
   Godo, Z
   Szentkereszty, Z
AF Nemeth, Norbert
   Peto, Katalin
   Deak, Adam
   Sogor, Viktoria
   Varga, Gabor
   Tanczos, Bence
   Balog, Klaudia
   Csiszko, Adrienn
   Godo, Zoltan
   Szentkereszty, Zsolt
TI Hemorheological factors can be informative in comparing treatment
   possibilities of abdominal compartment syndrome
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Abdominal compartment syndrome; negative pressure wound therapy;
   microcirculation; hemorheology
ID UPDATED CONSENSUS DEFINITIONS; CLINICAL-PRACTICE GUIDELINES;
   INTRAABDOMINAL HYPERTENSION; PRESSURE; CLOSURE; MANAGEMENT; RHEOLOGY
AB BACKGROUND: Abdominal compartment syndrome (ACS) is a life-threatening condition, of which pathomechanism hasn't been completely clarified, yet. Furthermore, surgical therapy still needs optimization.
   OBJECTIVE: We aimed to investigate microcirculatory and micro-rheological alterations in ACS, using various temporary abdominal closure methods, including three settings of vacuum-assisted closure technique (negative pressure wound therapy, NPWT).
   METHODS: On anesthetized pigs, by intraabdominally placed and filled-up silicone bags, intraabdominal pressure at 30mmHg was maintained for 3 hours, and afterwards, decompressive laparotomy happened. In different experimental groups Bogota-bag or Vivano abdominal sets were applied (-50, -100, -150 mmHg) for 2 hours. Pressure monitoring was done by implanted sensors, hemorheological parameters were determined, and laser Doppler flowmetry tests were performed on the surface of intraabdominal organs.
   RESULTS: Treatment with Bogota-bag and -150mmHg vacuum increased erythrocyte aggregation, while deformability declined. Blood viscosity increased after treatment with -150 mmHg vacuum. The microcirculatory parameters of the NPWT groups were better in small intestine.
   CONCLUSIONS: ACS resulted in impairment of macro- and micro-rheological parameters and abdominal organs' microcirculation. All of the used techniques improved the results, however, applying Bogota-bag or -150 mmHg vacuum set showed worse microcirculatory and micro-rheological data than the settings at -100 or -50 mmHg.
C1 [Nemeth, Norbert; Peto, Katalin; Deak, Adam; Sogor, Viktoria; Varga, Gabor; Tanczos, Bence] Univ Debrecen, Fac Med, Dept Operat Tech & Surg Res, Debrecen, Hungary.
   [Balog, Klaudia; Csiszko, Adrienn; Szentkereszty, Zsolt] Univ Debrecen, Fac Med, Inst Surg, Debrecen, Hungary.
   [Godo, Zoltan] Univ Debrecen, Fac Informat, Dept Informat Technol, Debrecen, Hungary.
C3 University of Debrecen; University of Debrecen; University of Debrecen
RP Nemeth, N (通讯作者)，Univ Debrecen, Fac Med, Dept Operat Tech & Surg Res, Inst Surg, Nagyerdeikrt 98, H-4032 Debrecen, Hungary.
EM nemeth@med.unideb.hu
RI ; Nemeth, Norbert/AAX-8704-2020; Petö, Katalin/IWD-5161-2023
OI Deak, Adam/0000-0001-7516-3152; Nemeth, Norbert/0000-0002-1162-3778;
   Tánczos, Bence/0000-0002-8892-3031; 
CR Arabadzhiev Georgi M, 2015, Clujul Med, V88, P188, DOI [10.15386/cjmed-455, 10.15386/cjmed-455]
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NR 28
TC 5
Z9 6
U1 0
U2 3
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2016
VL 64
IS 4
BP 765
EP 775
DI 10.3233/CH-168027
PG 11
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA EN3UU
UT WOS:000395934200028
PM 27767980
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Maruccia, M
   Onesti, MG
   Sorvillo, V
   Albano, A
   Dessy, LA
   Carlesimo, B
   Tarallo, M
   Marcasciano, M
   Giudice, G
   Cigna, E
   Ribuffo, D
AF Maruccia, Michele
   Onesti, Maria G.
   Sorvillo, Valentina
   Albano, Antonio
   Dessy, Luca A.
   Carlesimo, Bruno
   Tarallo, Mauro
   Marcasciano, Marco
   Giudice, Giuseppe
   Cigna, Emanuele
   Ribuffo, Diego
TI An Alternative Treatment Strategy for Complicated Chronic Wounds:
   Negative Pressure Therapy over Mesh Skin Graft
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; COMBINATION; INTEGRA
AB Extensive skin defect represents a real problem and major challenge in plastic and reconstructive surgery. On one hand, skin grafts offer a practical method to deal with skin defects despite their unsuitability for several complicated wounds. On the other hand, negative pressure wound therapy (NPWT), applied before skin grafting, promotes granulation tissue growth. The aim of the study is to evaluate the improvement in wound healing given by the merger of these two different approaches. We treated 23 patients for large wounds of multiple factors. Of these, 15 were treated with the application of V. A. C. "Therapy (KCI Medical S. r. l., Milan, Italy), in combination with skin grafts after a prior unsuccessful treatment of 4 weeks with mesh skin grafts and dressings. Another 8 were treated with only mesh skin graft. Pain reduction and wound area reduction were found statistically significant (P< 0.0009,P< 0.0001). Infection was resolved in almost all patients. According to our study, the use of the negative pressure wound therapy over mesh skin grafts is significantly effective especially in wounds resistant to conventional therapies, thereby improving the rate of skin graft take.
C1 [Maruccia, Michele; Onesti, Maria G.; Sorvillo, Valentina; Albano, Antonio; Dessy, Luca A.; Carlesimo, Bruno; Tarallo, Mauro; Marcasciano, Marco; Cigna, Emanuele; Ribuffo, Diego] Sapienza Univ Rome, Valdoni Surg Dept, Plast & Reconstruct Surg Unit, Viale Policlin 155, I-00161 Rome, Italy.
   [Maruccia, Michele; Giudice, Giuseppe] Univ Bari Aldo Moro, Emergency & Organ Transplantat Dept, Plast & Reconstruct Surg & Burns Unit, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
C3 Sapienza University Rome; Universita degli Studi di Bari Aldo Moro
RP Marcasciano, M (通讯作者)，Sapienza Univ Rome, Valdoni Surg Dept, Plast & Reconstruct Surg Unit, Viale Policlin 155, I-00161 Rome, Italy.
EM dott.marcomarcasciano@gmail.com
RI RIBUFFO, Diego/HLG-3305-2023; Marcasciano, Marco/HZJ-0259-2023; Tarallo,
   Mauro/AHD-1873-2022; Maruccia, Michele/ABE-9839-2020
OI RIBUFFO, Diego/0000-0002-1844-7850; 
CR Arias CA, 2009, NEW ENGL J MED, V360, P439, DOI 10.1056/NEJMp0804651
   Chen Jiong, 2009, Zhonghua Yi Xue Za Zhi, V89, P105
   Cigna E, 2013, INT WOUND J, V10, P534, DOI 10.1111/j.1742-481X.2012.01011.x
   de Laat EHEW, 2011, ANN PLAS SURG, V67, P626, DOI 10.1097/SAP.0b013e31820b3ac1
   Fioramonti P, 2012, IN VIVO, V26, P1053
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   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   Kaplan M, 2009, ADV SKIN WOUND CARE, V22, P128, DOI 10.1097/01.ASW.0000305451.71811.d5
   Milcheski DA, 2014, PRS-GLOB OPEN, V2, DOI 10.1097/GOX.0000000000000108
   Moiemen NS, 2010, BURNS, V36, P764, DOI 10.1016/j.burns.2010.04.011
   Mouës CM, 2007, J PLAST RECONSTR AES, V60, P672, DOI 10.1016/j.bjps.2006.01.041
   Onesti MG, 2011, G CHIR, V32, P83
   Onesti MG, 2016, INT WOUND J, V13, P1111, DOI 10.1111/iwj.12421
   Runkel N, 2011, INJURY, V42, pS1, DOI 10.1016/S0020-1383(11)00041-6
   Violas P, 2005, J PEDIATR ORTHOP B, V14, P381, DOI 10.1097/01202412-200509000-00013
NR 17
TC 21
Z9 27
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2017
VL 2017
AR 8395219
DI 10.1155/2017/8395219
PG 7
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA EN8BY
UT WOS:000396227100001
PM 28299333
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hurd, T
   Rossington, A
   Trueman, P
   Smith, J
AF Hurd, Theresa
   Rossington, Alan
   Trueman, Paul
   Smith, Jennifer
TI A Retrospective Comparison of the Performance of Two Negative Pressure
   Wound Therapy Systems in the Management of Wounds of Mixed Etiology
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; community care; silver dressings
ID VACUUM-ASSISTED CLOSURE; EVIDENCE-BASED RECOMMENDATIONS; RANDOMIZED
   CONTROLLED-TRIAL; INTERNATIONAL CONSENSUS; CARE; ULCERS; STEPS
AB Objective: Negative pressure wound therapy (NPWT) has been shown to be effective in the management of chronic and surgical wounds. The two most widely used modalities of NPWT are vacuum-assisted closure (V.A.C.) therapy (KCI, Inc., San Antonio, Texas) and the RENASYS NPWT system (Smith & Nephew, Hull, United Kingdom). This evaluation compares the performance of the two systems in the management of wounds of mixed etiology.
   Approach: The evaluation is based on retrospective evaluation of more than 1,000 patients treated with NPWT in a community setting in Canada.
   Results: Patients were well matched according to their baseline characteristics, including age, sex, and wound characteristics. No difference was seen between the two NPWT systems in terms of the percentage of patients reaching their predetermined treatment goal (90.0% and 93.6%, respectively). The time taken to achieve the treatment goal (median 8 weeks in both groups), percentage reduction in wound area (64.2% and 65.3%, respectively), and weekly rate of reduction in wound area (9.7% and 9.4%, respectively; p = 0.156).
   Innovation: This evaluation is believed to comprise the largest cohort of patients treated with NPWT published to date and is one of the few studies that have attempted to provide a direct comparison of the performance of alternative NPWT systems.
   Conclusion: Findings suggest that there are no clinically meaningful differences in the efficacy and performance of the two most widely used NPWT devices, based on consideration of a number of wound outcomes.
C1 [Hurd, Theresa] Nursing Practice Solut, Stevensville L0S 1S0, ON, Canada.
   [Rossington, Alan; Trueman, Paul; Smith, Jennifer] Smith & Nephew, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
C3 Smith & Nephew
RP Hurd, T (通讯作者)，Nursing Practice Solut, Stevensville L0S 1S0, ON, Canada.; Smith, J (通讯作者)，Smith & Nephew, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM theresa@nursingpracticesolutions.com; jennifer.smith@smith-nephew.com
CR [Anonymous], 2004, WOUNDS, p3S
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
   Dowsett C, 2012, INT WOUND J, V9, P544, DOI 10.1111/j.1742-481X.2011.00913.x
   Mouës CM, 2007, J PLAST RECONSTR AES, V60, P672, DOI 10.1016/j.bjps.2006.01.041
   Moues C M, 2005, J Wound Care, V14, P224
   Mouës CM, 2011, AM J SURG, V201, P544, DOI 10.1016/j.amjsurg.2010.04.029
   Rahmanian-Schwarz A, 2012, BURNS, V38, P573, DOI 10.1016/j.burns.2011.10.010
   Runkel N, 2011, INJURY, V42, pS1, DOI 10.1016/S0020-1383(11)00041-6
   Schultz Gregory S, 2004, Int Wound J, V1, P19, DOI 10.1111/j.1742-481x.2004.00008.x
   Siegel HJ, 2014, CLIN ORTHOP RELAT R, V472, P830, DOI 10.1007/s11999-013-3123-3
   Vig S, 2011, J TISSUE VIABILITY, V20, pS1, DOI 10.1016/j.jtv.2011.07.002
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   Whitehead SJ, 2011, INT WOUND J, V8, P22, DOI 10.1111/j.1742-481X.2010.00739.x
   Willy C., 2006, The Theory and Practice of Vacuum Therapy: Scientific basis, Indications for use, case reports, practical advice
NR 16
TC 7
Z9 9
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JAN
PY 2017
VL 6
IS 1
BP 33
EP 37
DI 10.1089/wound.2015.0679
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EO2LA
UT WOS:000396526800004
PM 28116226
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Izzo, V
   Meloni, M
   Giurato, L
   Ruotolo, V
   Uccioli, L
AF Izzo, Valentina
   Meloni, Marco
   Giurato, Laura
   Ruotolo, Valeria
   Uccioli, Luigi
TI The Effectiveness of Negative Pressure Therapy in Diabetic Foot Ulcers
   with Elevated Protease Activity: A Case Series
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE foot ulcers; negative pressure; chronic wounds
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; MATRIX METALLOPROTEINASES;
   CONTROLLED-TRIAL; MANAGEMENT; EXPRESSION; MECHANISM; FLUID; PROMOGRAN;
   REPAIR
AB Objective: Despite several works have described the usefulness of negative pressure therapy (NPT) in the treatment of diabetic foot ulcers (DFUs), no studies have reported its ability in the proteases modulation in DFUs. The aim of this work was to evaluate the role of NPT as a protease-modulating treatment in DFUs.
   Approach: We conducted a prospective study of a series of diabetic patients affected by chronic DFUs. Each ulcer was assessed for matrix metalloproteinases (MMPs) activity with a protease status diagnostic test at the baseline and after 2 weeks of NPT.
   Results: Four patients were included. All patients had type 2 diabetes with a disease duration of approximate to 20 years. A1c was 79.5 +/- 15.3 mmol/mol. Ulcer area was >5 cm(2) in all cases. All wounds showed elevated protease activity (EPA) at the baseline. After 2 weeks, all patients showed a normalization of MMPs activity.
   Innovation: NPT showed its effectiveness in the reduction of EPA in chronic DFUs.
   Conclusion: This study confirms the role of NPT in the positive modulation of protease activity also in chronic DFUs.
C1 [Izzo, Valentina; Meloni, Marco; Giurato, Laura; Ruotolo, Valeria; Uccioli, Luigi] Univ Tor Vergata, Dept Syst Med, Viale Oxford 81, I-00133 Rome, Italy.
C3 University of Rome Tor Vergata
RP Izzo, V (通讯作者)，Univ Tor Vergata, Dept Syst Med, Viale Oxford 81, I-00133 Rome, Italy.
EM valentina_izzo@virgilio.it
RI Meloni, Marco/AAB-9309-2019; uccioli, luigi/AAF-4844-2020; Izzo,
   Valentina/AAO-9874-2020
OI Meloni, Marco/0000-0003-3789-9622; 
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 35
TC 4
Z9 7
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JAN
PY 2017
VL 6
IS 1
BP 38
EP 42
DI 10.1089/wound.2016.0700
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EO2LA
UT WOS:000396526800005
PM 28116227
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Cristaudo, A
   Jennings, S
   Gunnarsson, R
   Decosta, A
AF Cristaudo, Adam
   Jennings, Scott
   Gunnarsson, Ronny
   Decosta, Alan
TI Complications and Mortality Associated with Temporary Abdominal Closure
   Techniques: A Systematic Review and Meta-Analysis
SO AMERICAN SURGEON
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; DAMAGE-CONTROL
   LAPAROTOMY; OPEN ABDOMEN TREATMENT; PRIMARY FASCIAL CLOSURE; DELAYED
   PRIMARY CLOSURE; SEVERE INTRAABDOMINAL INFECTION; AORTIC-ANEURYSM
   REPAIR; COMPARTMENT SYNDROME; OPEN MANAGEMENT
AB Temporary abdominal closure (TAC) techniques are routinely used in the open abdomen. Ideally, they should prevent evisceration, aid in removal of unwanted fluid from the peritoneal cavity, facilitate in achieving safe definitive fascial closure, as well as prevent the development of intra-abdominal complications. TAC techniques used in the open abdomen were compared with negative pressure wound therapy (NPWT) to identifywhich was superior. Asystematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines involving Medline, Excerpta Medica, Cochrane Central Register of Controlled Trials, Cumulative Index toNursing andAlliedHealth Literature, and Clinicaltrials. gov. All studies describing TAC technique use in the open abdomen were eligible for inclusion. Data were analyzed per TAC technique in the form of a meta-analysis. A total of 225 articles were included in the final analysis. A meta-analysis involving only randomized controlled trials showed that NPWT with continuous fascial closure was superior to NPWT alone for definitive fascial closure [ mean difference (MD): 35% +/- 23%; P = 0.0044]. A subsequent meta-analysis involving all included studies confirmed its superiority across outcomes for definitive fascial closure (MD: 19% +/- 3%; P < 0.0001), perioperative (MD: -4.0% +/- 2.4%; P 5 0.0013) and in-hospital (MD: -5.0% +/- 2.9%; P = 0.0013) mortality, entero-atmospheric fistula (MD: -2.0% +/- 1.8%; P = 0.0041), ventral hernia (MD: -4.0% +/- 2.4%; P = 0.0010), and intra-abdominal abscess (MD: -3.1% 6 2.1%; P = 0.0044). Therefore, it was concluded that NPWTwith continuous fascial traction is superior to NPWTalone.
C1 [Cristaudo, Adam] Univ Sydney, Sydney Med Sch, Camperdown, NSW, Australia.
   [Jennings, Scott] Flinders Med Ctr, Dept Cardiothorac Surg, Adelaide, SA, Australia.
   [Gunnarsson, Ronny] James Cook Univ, Cairns Hosp, Sch Med, Cairns, Qld, Australia.
   [Decosta, Alan] Cairns Hosp, Dept Surg, Cairns, Qld, Australia.
C3 University of Sydney; Flinders Medical Centre; Queensland Health; Cairns
   Hospital; James Cook University; Queensland Health; Cairns Hospital
RP Cristaudo, A (通讯作者)，Univ Sydney, Sydney Med Sch, Camperdown, NSW, Australia.; Cristaudo, A (通讯作者)，2 Hubner Dr, Rothwell, Qld 4022, Australia.
EM adamcristaudo@bigpond.com
RI Gunnarsson, Ronny Kent/AAH-4811-2019; de Costa, Alan/AAZ-3441-2021
OI Gunnarsson, Ronny Kent/0000-0001-9183-3072; de Costa,
   Alan/0000-0001-8116-8099
FU University of Sydney and the academic staff of the Sydney Medical
   School's Discipline of Surgery
FX I would like to acknowledge the support of the University of Sydney and
   the academic staff of the Sydney Medical School's Discipline of Surgery.
   In particular, Dr. Kerry Hitos for the support throughout the surgical
   research component of Masters of Surgery coursework, which you so kindly
   are continuing as I embark on of my PhD. I would also like to
   acknowledge the last minute statistical support from Dr. RobertWare from
   University of Queensland School of Medicine. I would also like to
   especially acknowledge the strong support I have received from my family
   and friends in regard to this research. Especially to my wife, who has
   spent the majority of the last year watching as I stare at my computer.
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NR 250
TC 39
Z9 49
U1 0
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD FEB
PY 2017
VL 83
IS 2
BP 191
EP 216
PG 26
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EO7ZC
UT WOS:000396907600020
PM 28228207
DA 2026-07-24
ER
PT J
AU Ren, GH
   Li, RG
   Jiang, GY
   Chen, CJ
   Bao, ZG
AF Ren Gao-hong
   Li Run-guang
   Jiang Gui-yong
   Chen Chao-jie
   Bao Zhi-gang
TI A solution to the vessel shortage during free vascularized fibular
   grafting for reconstructing infected bone defects of the femur: Bridging
   with vein transplantation
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Bone defect repair; Infected femur bone defect; Orthopedic infection;
   Vascularized fibular graft; Vessel transplantation
ID DONOR-SITE MORBIDITY; FREE-FLAP TRANSPLANTATION; VACUUM SEALING
   DRAINAGE; PRESSURE WOUND THERAPY; OSTEOMYELITIS; TRANSPORT;
   METAANALYSIS; EXTREMITIES; KNEE
AB Purpose: The present study aimed to evaluate the feasibility and clinical efficacy of bridging vein transplantation to deal with the vessel shortage during free vascularized fibular grafting for reconstructing infected bone defects of the femur.
   Methods: Twelve patients (aged 15-58 years) with infected bone defects of the femur (between 6.0 and 18.0 cm) were recruited in this study. Vacuum sealing drainage were applied after extensive debridement of the infected bone defects and irrigated with 0.9% sodium chloride solution for 1-2 weeks. After the drainage was clear and the focal infections were controlled, the free vascularized fibula was harvested for reconstructing the femoral bone defects. The vascularized fibula was grafted and fixated appropriately at the recipient site. The autogenous great saphenous vein was harvested, one end was anastomosed and bridged the vascular pedicles of the fibular grafts, and the other end anastomosed the artery and/ or the vein in the recipient healthy site.
   Results: Mean length of vein transplantationwith vascularized fibular graft was 10.2 cm (range 7-15 cm). All patients had good radiological healing without recorded nonunion or malunion. No patient developed deep infection or implant failure. Primary bone healing was achieved in 10 patients; however, 2 grafted fibular formed pseudarthrosis with the recipient femoral and then healed after a secondary surgery. One patient suffered from graft stress fracture after bone healing and healed after external fixation. After the mean follow-up of 30 months (9-72 months), according to the Enneking scoring system, clinical outcomes were excellent in 7 patients, good in 4 and fair in one. The functional recovery rate of the lesion limb was 89.4%.
   Conclusions: Free vascularized fibular graft with vein transplantation bridged vascular pedicle can effectively repair the infected bone, improve blood supply to the bone defect site, and help control infection. It is a feasible and effective treatment for infected bone defects of the femur with poor soft tissue conditions, or blood supply vessel shortage. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Ren Gao-hong; Li Run-guang; Jiang Gui-yong; Chen Chao-jie; Bao Zhi-gang] Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China.
C3 Southern Medical University - China
RP Ren, GH (通讯作者)，Southern Med Univ, Dept Orthopaed & Traumatol, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China.
EM doctor020@163.com
RI ; Chen, Chaojie/PCQ-6635-2025; Jiang, Guiyong/LRB-3721-2024
OI Gaohong, Ren/0000-0002-4941-6723; Runguang, Li/0000-0002-4703-7180; 
FU Natural Science Foundation of Guangdong Province [S2012010009434];
   "Special Project on the Integration of Industry, Education and Research
   of Guangdong Province" in China [2012B091100462]
FX This work was supported by the "Natural Science Foundation of Guangdong
   Province" (Approval number S2012010009434) and "Special Project on the
   Integration of Industry, Education and Research of Guangdong Province"
   (Approval number 2012B091100462) in China.
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NR 40
TC 13
Z9 20
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2017
VL 48
IS 2
BP 486
EP 494
DI 10.1016/j.injury.2016.10.027
PG 9
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA EO8BO
UT WOS:000396914100044
PM 27876350
DA 2026-07-24
ER
PT J
AU Yang, F
   Shi, B
   Cao, L
AF Yang, Fen
   Shi, Bing
   Cao, Ling
TI Effect of vacuum sealing drainage on the expression of VEGF and
   miRNA-17-5p in seawater-immersed blast-injury wounds
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE vacuum sealing drainage; seawater immersion; blast injury; miRNA;
   vascular endothelial growth factor
ID SOFT-TISSUE; ASSISTED CLOSURE; SKIN; ANGIOGENESIS; MICRORNAS;
   EXPERIENCE; THERAPY; DEVICE
AB The aim of the present study was to compare and observe the expression levels of vascular endothelial growth factor (VEGF) and miRNA-17-5p during the treatment of seawater-immersed blast-injury wounds (SIBIW) under different conditions of vacuum sealing drainage (VSD), and to identify the optimized range of VSD treatment and partially explain its mechanisms. The bilateral hips and scapulae of experimental pigs (weight, 25-30 kg) were subjected to blast-injury wounds, followed by the seawater immersion. The animals then underwent conventional dressing treatment under 120, 180 and 240 mmHg VSD. Visual observation, in addition to histological, immunohistochemical and molecular biological techniques were applied to compare and observe the extent of wound healing and expression levels of VEGF and miRNA-17-5p. The wound healing of the VSD treatment group was improved compared with the control group, with 120 mmHg negative pressure producing the most marked effect. miR-17-5p expression was detected in the SIBIW granulation tissues. There was significant difference between each VSD treatment group and control group at each time point (P < 0.05). Thus, the present results show that miR-17-5p can be expressed in SIBIW granulation tissues, and this effect is most evident under 120 mmHg negative pressure, which may inform the optimized negative range for the treatment of SIBIW.
C1 [Yang, Fen] Bayannur City Hosp, Dept Burns & Plast Surg, Bayannur 015000, Inner Mongolia, Peoples R China.
   [Shi, Bing; Cao, Ling] 309th Hosp PLA, Dept Plast & Reconstruct Surg, Beijing 100091, Peoples R China.
RP Shi, B (通讯作者)，309th Hosp PLA, Dept Plast & Reconstruct Surg, Beijing 100091, Peoples R China.
EM bingshidoc@163.com
CR Altintas B, 2014, INT WOUND J
   Atay T, 2013, INDIAN J SURG, V75, P302, DOI 10.1007/s12262-012-0490-z
   Bonauer A, 2009, SCIENCE, V324, P1710, DOI 10.1126/science.1174381
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NR 33
TC 9
Z9 11
U1 0
U2 16
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAR
PY 2017
VL 13
IS 3
BP 1081
EP 1086
DI 10.3892/etm.2017.4057
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EO9JJ
UT WOS:000397004700045
PM 28450946
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Heard, C
   Chaboyer, W
   Anderson, V
   Gillespie, BM
   Whitty, JA
AF Heard, Christopher
   Chaboyer, Wendy
   Anderson, Vinah
   Gillespie, Brigid M.
   Whitty, Jennifer A.
TI Cost-effectiveness analysis alongside a pilot study of prophylactic
   negative pressure wound therapy
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Wounds; Surgical site infection; Negative pressure wound therapy;
   Caesarean section; Cost-effectiveness analysis
ID SURGICAL SITE INFECTION; HEALTH
AB Background: Negative pressure wound therapy (NPWT) is increasingly used prophylactically following surgery despite limited evidence of clinical or cost-effectiveness.
   Objective: To evaluate whether NPWT is cost-effective compared to standard care, for the prevention of surgical site infection (SSI) in obese women undergoing elective caesarean section, and inform development of a larger trial.
   Methods: An economic evaluation was conducted alongside a pilot randomised controlled trial at one Australian hospital, in which women were randomised to NPWT (n = 44) or standard care (n = 43). A public health care provider perspective and time horizon to four weeks post-discharge was adopted. Cost-effectiveness assessment was based on incremental cost per SSI prevented and per quality-adjusted life year (QALY) gained.
   Results: Patients receiving NPWT each received health care costing AU$5887 (+/- 1038) and reported 0.069 (+/- 0.010) QALYs compared to AU$5754 (+/- 1484) and 0.066 (+/- 0.010) QALYs for patients receiving standard care. NPWT may be slightly more costly and more effective than standard care, with estimated incremental cost-effectiveness ratios (ICERs) of AU$1347 (95%CI dominant-$41,873) per SSI prevented and AU$42,340 (95%Cl dominant-$884,019) per QALY gained. However, there was considerable uncertainty around these estimates.
   Conclusions: NPWT may be cost-effective in the prophylactic treatment of surgical wounds following elective caesarean section in obese women. Larger trials could clarify the cost-effectiveness of NPWT as a prophylactic treatment for SSI. Sensitive capture of QALYs and cost offsets will be important given the high level of uncertainty around the point estimate cost-effectiveness ratio which was close to conventional thresholds. (C) 2016 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.
C1 [Heard, Christopher; Whitty, Jennifer A.] Univ Queensland, Fac Hlth & Behav Sci, Sch Pharm, St Lucia, Qld, Australia.
   [Chaboyer, Wendy; Anderson, Vinah; Gillespie, Brigid M.; Whitty, Jennifer A.] Griffith Univ, Ctr Res Excellence Nursing, NHMRC, Gold Coast, Qld, Australia.
   [Chaboyer, Wendy; Anderson, Vinah; Gillespie, Brigid M.; Whitty, Jennifer A.] Menzies Hlth Inst Queensland, Gold Coast, Qld, Australia.
   [Whitty, Jennifer A.] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
C3 University of Queensland; Griffith University; Menzies Health Institute
   Queensland; University of East Anglia
RP Whitty, JA (通讯作者)，Univ East Anglia, Fac Med & Hlth Sci, Norwich Med Sch, Hlth Econ Grp, Norwich Res Pk, Norwich NR4 7JT, Norfolk, England.
EM Jennifer.Whitty@uea.ac.uk
RI ; Chaboyer, Wendy/F-9588-2018; Gillespie, Brigid/E-7799-2012; Whitty,
   Jennifer/N-6434-2013
OI Anderson, Vinah/0000-0001-9924-0159; Chaboyer,
   Wendy/0000-0001-9528-7814; Gillespie, Brigid/0000-0003-3186-5691; 
FU Office of Health and Medical Research; Queensland Health; National
   Health and Medical Research Council Centre of Research Excellence in
   Nursing; Gold Coast University Hospital Private Practice grant;
   University of Queensland under the UQ Summer Research Scholarship
   program
FX The pilot study was funded by the Office of Health and Medical Research,
   Queensland Health, the National Health and Medical Research Council
   Centre of Research Excellence in Nursing and a Gold Coast University
   Hospital Private Practice grant. Christopher Heard received funding from
   The University of Queensland under the UQ Summer Research Scholarship
   program.
CR Andersson AE, 2010, AM J INFECT CONTROL, V38, P711, DOI 10.1016/j.ajic.2010.03.017
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NR 32
TC 42
Z9 43
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-206X
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2017
VL 26
IS 1
SI SI
BP 79
EP 84
DI 10.1016/j.jtv.2016.06.001
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA EP0JO
UT WOS:000397073800011
PM 27320010
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Sreelesh, LS
   Bhandari, PL
AF Sreelesh, L. S.
   Bhandari, P. Laxminarayan
TI An Easy Technique for Negative-Pressure Wound Therapy for Extremities
   Using Collagen Powder and Sterile Gloves
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; Collagen; Sterile gloves; Extremity VAC
AB Negative-pressure wound therapy (NPWT) has become the standard of care for wound management. Application of NPWT to the hand and foot is technically challenging due to difficulty in obtaining a proper air seal. The cost of the treatment is another negative factor affecting NPWT in developing countries. We describe an easy and economical technique for the application of NPWT to the extremities using collage powder and sterile surgical glove. Collagen creates a physiological interface between the wound surface and the environment and is also non-immunogenic, non-pyrogenic, hypoallergenic, and pain-free. We used this method in 20 patients. In all cases, we could achieve a proper air seal and significantly reduce the cost. The median duration of NPWT application was 9 days. This combination turned out to be a good alternative to traditional VAC with respect to the duration and cost of treatment and also ergonomically better in the management of extremity wounds.
C1 [Sreelesh, L. S.; Bhandari, P. Laxminarayan] Govt Med Coll, Dept Plast Surg, Kozhikode 673008, Kerala, India.
RP Sreelesh, LS (通讯作者)，Govt Med Coll, Dept Plast Surg, Kozhikode 673008, Kerala, India.
EM sreeleshls@yahoo.com
RI Bhandari, Panambur Laxminarayan/AAW-4512-2020
CR Hemmanur SR, 2013, ARCH PLAST SURG-APS, V40, P630, DOI 10.5999/aps.2013.40.5.630
   Nataraj C, 2007, WOUNDS, V19, P148
   Ng R, 2006, J PLAST RECONSTR AES, V59, P1011, DOI 10.1016/j.bjps.2006.02.002
   NODA K, 1984, GANN, V75, P109
   Tauro LF, 2007, INDIAN J PLAST SURG, V40, P133, DOI 10.4103/0970-0358.33429
NR 5
TC 7
Z9 8
U1 0
U2 1
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD FEB
PY 2017
VL 79
IS 1
BP 81
EP 83
DI 10.1007/s12262-017-1589-z
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EP2TM
UT WOS:000397236200020
PM 28331276
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Rowan, MP
   Niece, KL
   Rizzo, JA
   Akers, KS
AF Rowan, Matthew P.
   Niece, Krista L.
   Rizzo, Julie A.
   Akers, Kevin S.
TI Wound Penetration of Cefazolin, Ciprofloxacin, Piperacillin, Tazobactam,
   and Vancomycin During Negative Pressure Wound Therapy
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE antibiotic; burn; exudate; pharmacokinetics; trauma; WoundVac
ID VACUUM-ASSISTED CLOSURE; PROTEIN-BINDING; LASER-DOPPLER;
   PHARMACOKINETICS; PHARMACODYNAMICS; BIOMARKERS; DRESSINGS; SURGERY;
   SINGLE; FUTURE
AB Objective: Negative pressure wound therapy (NPWT) uses subatmospheric pressure as a noninvasive adjunct to treat wounds and has demonstrated clinical efficacy by accelerating healing of a variety of acute and chronic wounds. NPWT may also play a role in preventing or treating wound infections, possibly by increasing wound penetration of antibiotics. However, clinical data in patients undergoing antibiotic and NPWT treatment are limited.
   Approach: To evaluate the wound penetration of antibiotics in NPWT patients, we conducted a prospective, observational study of burn and trauma patients treated with NPWT and systemic antibiotics. We evaluated the plasma pharmacokinetic profile of systemic vancomycin, ciprofloxacin, cefazolin, and piperacillin/tazobactam, as well as total and unbound antibiotic concentrations in wound exudate from the same patients.
   Results: Data from 32 patients with 37 wounds undergoing NPWT demonstrated that vancomycin, ciprofloxacin, and piperacillin/tazobactam all penetrated wounds with exudate to plasma concentration ratios more than 0.8. Cefazolin did not penetrate wounds in patients undergoing NPWT as effectively, with an average exudate to plasma concentration ratio of 0.51.
   Innovation: Clinical data on the wound penetration of antibiotics in patients undergoing NPWT are limited, but these data suggest that antibiotics have different capacities for wound penetration during NPWT that should be considered when making clinical decisions.
   Conclusion: This initial report suggests that (1) vancomycin, ciprofloxacin, and piperacillin/tazobactam effectively penetrate wounds during NPWT and (2) cefazolin as well as other antibiotics may not penetrate wounds during NPWT.
C1 [Rowan, Matthew P.; Niece, Krista L.; Rizzo, Julie A.; Akers, Kevin S.] JBSA Ft Sam Houston, United States Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
   [Rizzo, Julie A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA.
   [Akers, Kevin S.] JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX USA.
C3 Uniformed Services University of the Health Sciences - USA; Brooke Army
   Medical Center
RP Akers, KS (通讯作者)，JBSA Ft Sam Houston, United States Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.; Akers, KS (通讯作者)，JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX USA.
EM kevin.s.akers.mil@mail.mil
FU Defense Medical Research and Development Program (DMRDP) Military
   Infectious Disease Clinical Trial Award (MID-CTA) [D_MIDCTA_I_12_J2_299]
FX This work is dedicated to the life, memory, and enduring spirit of Dr.
   Matthew P. "Matt'' Rowan, PhD, a public servant devoted to the
   betterment of humanity through biomedical research. Dr. Rowan was killed
   a few days after completing this, his final article. We would like to
   thank the research nurses and staff for their assistance in conducting
   this study, especially Doug Johnson for his contribution and effort; the
   Department of Clinical Investigations at Brooke Army Medical Center for
   laboratory support; and Drs. Kevin Chung and Michelle Buehner for
   critical review of the article. This study was conducted under a
   protocol reviewed and approved by the U.S. Army Medical Research and
   Materiel Command Institutional Review Board and in accordance with the
   approved protocol. This research was supported by Defense Medical
   Research and Development Program (DMRDP) Military Infectious Disease
   Clinical Trial Award (MID-CTA) No. D_MIDCTA_I_12_J2_299 and, in part, by
   an appointment (M.P.R.) to the Postgraduate Research Participation
   Program at the U.S. Army Institute of Surgical Research administered by
   the Oak Ridge Institute for Science and Education through an interagency
   agreement between the U.S. Department of Energy and the U.S. Army
   Medical Research and Materiel Command.
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   Utz ER, 2010, J SURG RES, V159, P633, DOI 10.1016/j.jss.2009.08.021
   Vella-Brincat JWA, 2007, BRIT J CLIN PHARMACO, V63, P753, DOI 10.1111/j.1365-2125.2006.02827.x
NR 30
TC 11
Z9 12
U1 0
U2 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD FEB
PY 2017
VL 6
IS 2
BP 55
EP 62
DI 10.1089/wound.2016.0698
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EP3DG
UT WOS:000397262200002
PM 28224048
DA 2026-07-24
ER
PT J
AU Zaidi, A
   El-Masry, S
AF Zaidi, A.
   El-Masry, S.
TI Closed-incision negative-pressure therapy in high-risk general surgery
   patients following laparotomy: a retrospective study
SO COLORECTAL DISEASE
LA English
DT Article
DE Closed incision; negative-pressure therapy; general surgery; laparotomy;
   high risk
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; RANDOMIZED
   CONTROLLED-TRIAL; OPEN COLORECTAL SURGERY; WOUND THERAPY; MANAGEMENT;
   MECHANISMS; RESECTION; PROTOCOL; COST
AB Aim Surgical site infection (SSI) and wound dehiscence are dreaded complications following laparotomy in general surgical patients, and can potentially occur more often in various comorbid states. Negative-pressure wound therapy (NPWT) has a positive effect of on open and complicated wounds and so has been used for atrisk surgical incisions with the aim of redistributing lateral tension and holding incision edges together. The aim of the present study was to compare the rate of wound complications following laparotomy in high-risk general surgical patients with a clean incision treated with closed-incision negative-pressure therapy (ciNPT) with those receiving conventional care.
   Method A retrospective review was performed of the hospital medical records of patients who underwent laparotomy between 1 October 2010 and 31 March 2012. Records of 69 patients who received ciNPT and 112 who were managed by adherent gauze dressings were included in the final analysis.
   Results Two (2.9%) patients in the ciNPT group and 23 (20.5%) in the non-NPWT group developed a wound complication following laparotomy (P < 0.0009). The relative risk (RR) was 0.14 (0.03-0.58), suggesting that infection is less likely to occur in ciNPT-treated incisions, compared with gauze dressings.
   Conclusion ciNPT was associated with a positive clinical outcome and was a safe and effective method of postsurgical management in our general surgery patients considered to have risk of developing wound complications following laparotomy.
C1 [Zaidi, A.] North Tees & Hartlepool NHSFT, Stockton, CA USA.
   [El-Masry, S.] Our Lady Lourdes, Louth, Ireland.
RP El-Masry, S (通讯作者)，Our Lady Lourdes Hosp, Consultant Colorectal Surgeon, FRCSI, Louth, Ireland.
EM selmasry@rcsi.ie
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NR 25
TC 51
Z9 56
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD MAR
PY 2017
VL 19
IS 3
BP 283
EP 287
DI 10.1111/codi.13458
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA EP3FD
UT WOS:000397267300010
PM 27416813
OA hybrid
DA 2026-07-24
ER
PT J
AU Sun, XF
   Ni, PW
   Wu, MJ
   Yao, H
   Ye, J
   Ting, X
AF Sun, Xiaofang
   Ni, Pengwen
   Wu, Minjie
   Yao, Huang
   Ye, Junna
   Ting, Xie
TI A Clinicoepidemiological Profile of Chronic Wounds in Wound Healing
   Department in Shanghai
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE chronic wounds; demography; etiology; therapy; cost
ID VENOUS LEG ULCERS; PRESSURE ULCERS; DIABETIC FOOT; SURGICAL-TREATMENT;
   UNITED-STATES; RISK-FACTORS; PREVALENCE; MANAGEMENT; THERAPY; CHINA
AB The aim of the study was to update the clinical database of chronic wounds in order to derive an evidence based understanding of the condition and hence to guide future clinical management in China. A total of 241 patients from January 1, 2011 to April 30, 2016 with chronic wounds of more than 2 weeks' duration were studied in wound healing department in Shanghai. Results revealed that among all the patients the mean age was 52.5 +/- 20.2 years (range 2-92 years). The mean initial area of wounds was 30.3 +/- 63.0 cm2 (range 0.25-468 cm2). The mean duration of wounds was 68.5 +/- 175.2 months (range 0.5-840 months). The previously reported causes of chronic wounds were traumatic or surgical wounds (n = 82, 34.0%), followed by pressure ulcers (n = 59, 24.5%). To study the effects of age, patients were divided into 2 groups: less than 60 years (<60), and 60 years or older (>= 60). The proportion of wounds etiology between the 2 age groups was analyzed, and there was significant statistical difference (P < .05, 95% confidence interval [CI] = 0.076-0.987). To study the associations between outcome and clinical characteristics in chronic wounds, chi-square test was used. There were significant differences in the factor of wound infection. (P = .035, 95% CI = 0.031-0.038) Regarding therapies, 72.6% (n = 175) of the patients were treated with negative pressure wound therapy. Among all the patients, 29.9% (n = 72) of them were completely healed when discharged while 62.7% (n = 150) of them improved. The mean treatment cost was 12055.4 +/- 9206.3 Chinese Yuan (range 891-63626 Chinese Yuan). In conclusion, traumatic or surgical wounds have recently become the leading cause of chronic wounds in Shanghai, China. Etiology of the 2 age groups was different. Infection could significantly influence the wound outcome.
C1 [Sun, Xiaofang; Ni, Pengwen; Wu, Minjie; Yao, Huang; Ting, Xie] Shanghai Jiao Tong Univ, Shanghai 9th Peoples Hosp, Sch Med, Wound Healing Dept, Shanghai 200011, Peoples R China.
   [Ye, Junna] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai 200011, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Ting, X (通讯作者)，Shanghai Jiao Tong Univ, Shanghai 9th Peoples Hosp, Sch Med, Wound Healing Dept, Shanghai 200011, Peoples R China.
EM doctortingxie@139.com
RI Ye, Junna/ABF-6141-2020; xie, ting/HNC-0777-2023
FU National Natural Science Foundation of China [81671917, 81272111];
   Translational Medical Research Institute Stem Cells and Regenerative
   Medicine Base in Shanghai Jiao Tong University School of Medicine
   [TS201109]; National Scientific & Technology Pillar Program
   [2012BAI11B04]; Major State Basic Research Development Program of China
   [2012CB518100]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by grants from the National Natural Science Foundation of
   China (81671917, 81272111), Translational Medical Research Institute
   Stem Cells and Regenerative Medicine Base in Shanghai Jiao Tong
   University School of Medicine (TS201109), the National Scientific &
   Technology Pillar Program (2012BAI11B04), and the Major State Basic
   Research Development Program of China (2012CB518100).
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NR 37
TC 21
Z9 32
U1 1
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2017
VL 16
IS 1
BP 36
EP 44
DI 10.1177/1534734617696730
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EP7TC
UT WOS:000397579100006
PM 28682680
DA 2026-07-24
ER
PT J
AU Han, G
   Ceilley, R
AF Han, George
   Ceilley, Roger
TI Chronic Wound Healing: A Review of Current Management and Treatments
SO ADVANCES IN THERAPY
LA English
DT Review
DE Biofilms; Chronic wounds; Growth factors; Hyperbaric oxygen; Negative
   pressure wound therapy; Skin infection; Skin substitutes; Wound
   dressings; Wound healing
ID HYPERBARIC-OXYGEN THERAPY; CADEXOMER IODINE; RANDOMIZED TRIAL;
   CLINICAL-TRIAL; FOOT ULCERS; FETAL SKIN; VITAMIN-E; CARE; COLLAGEN;
   PROPHYLAXIS
AB Wound healing is a complex, highly regulated process that is critical in maintaining the barrier function of skin. With numerous disease processes, the cascade of events involved in wound healing can be affected, resulting in chronic, non-healing wounds that subject the patient to significant discomfort and distress while draining the medical system of an enormous amount of resources. The healing of a superficial wound requires many factors to work in concert, and wound dressings and treatments have evolved considerably to address possible barriers to wound healing, ranging from infection to hypoxia. Even optimally, wound tissue never reaches its pre-injured strength and multiple aberrant healing states can result in chronic non-healing wounds. This article will review wound healing physiology and discuss current approaches for treating a wound.
C1 [Han, George] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
   [Ceilley, Roger] Univ Iowa, Iowa City, IA USA.
C3 Icahn School of Medicine at Mount Sinai; University of Iowa
RP Han, G (通讯作者)，Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
EM george.han@mountsinai.org
OI Han, George/0000-0003-3302-5098
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NR 72
TC 1641
Z9 1965
U1 51
U2 1391
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0741-238X
EI 1865-8652
J9 ADV THER
JI Adv. Ther.
PD MAR
PY 2017
VL 34
IS 3
BP 599
EP 610
DI 10.1007/s12325-017-0478-y
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EQ3NB
UT WOS:000397978600002
PM 28108895
OA hybrid
HC Y
HP N
DA 2026-07-24
ER
PT J
AU Marongiu, F
   Buggi, F
   Mingozzi, M
   Curcio, A
   Folli, S
AF Marongiu, Francesco
   Buggi, Federico
   Mingozzi, Matteo
   Curcio, Annalisa
   Folli, Secondo
TI A rare case of primary necrotising fasciitis of the breast: combined use
   of hyperbaric oxygen and negative pressure wound therapy to conserve the
   breast. Review of literature
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Breast conservation; Hyperbaric oxygen; Negative pressure wound therapy;
   Primary necrotising fasciitis of the breast
ID INFECTION
AB Necrotising fasciitis is a rare but potentially fatal disease. It is even more unusual as a primary disease of the breast. Surgical treatment is required in order to gain control over the spreading infection and mastectomy is reported to be the most common procedure. We report the first case of an otherwise healthy woman exhibiting a primary necrotising fasciitis of the breast, which was treated combining conservative surgery with hyperbaric oxygen (HO) and negative pressure wound therapy (NPWT). A 39-year-old woman presented to the emergency room with fever and swelling of her right breast. The physical examination showed oedema and erythema of the breast, with bluish blisters on the lower quadrant. Ultrasound and CT scans showed diffuse oedema of the entire right breast, with subdermal gas bubbles extending to the fascial planes. Few hours later the necrotic area extended regardless an IV antibiotic therapy; a selective debridement of all breast necrotic tissue was performed and repeated 7 days later. The HO was started immediately after the first surgery and repeated daily (2.8Bar, 120 min) for 18 days and then a NPWT (120-135 mmHg) was applied. Forty-five days after the last debridement, the breast wound was covered with a full-thickness skin graft. Several months later, an excellent cosmetic result was observed. This is the first case of primary necrotising fasciitis of the breast treated associating HO and NPWT to surgical debridement only; this combination resulted in a complete recovery with the additional benefit of breast conservation. Such result is discussed in light of the available literature on the treatment of primary necrotising fasciitis of the breast.
C1 [Marongiu, Francesco; Buggi, Federico; Mingozzi, Matteo; Curcio, Annalisa; Folli, Secondo] Morgagni Pierantoni Hosp, Breast Unit, Via Carlo Forlanini 34, I-07100 Sassari, Italy.
RP Marongiu, F (通讯作者)，Morgagni Pierantoni Hosp, Breast Unit, Via Carlo Forlanini 34, I-07100 Sassari, Italy.
EM marongiufra@gmail.com
RI Folli, Secondo/AAB-2227-2020
OI Folli, Secondo/0000-0003-3465-3010
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NR 18
TC 15
Z9 17
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2017
VL 14
IS 2
BP 349
EP 354
DI 10.1111/iwj.12607
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EQ4SH
UT WOS:000398068200009
PM 27146346
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Willy, C
   Agarwal, A
   Andersen, CA
   De Santis, G
   Gabriel, A
   Grauhan, O
   Guerra, OM
   Lipsky, BA
   Malas, MB
   Mathiesen, LL
   Singh, DP
   Reddy, VS
AF Willy, Christian
   Agarwal, Animesh
   Andersen, Charles A.
   De Santis, Giorgio
   Gabriel, Allen
   Grauhan, Onnen
   Guerra, Omar M.
   Lipsky, Benjamin A.
   Malas, Mahmoud B.
   Mathiesen, Lars L.
   Singh, Devinder P.
   Reddy, V. Sreenath
TI Closed incision negative pressure therapy: international
   multidisciplinary consensus recommendations
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Consensus recommendation; Negative pressure therapy; Surgical incision
   management; Surgical site infection
ID SURGICAL-SITE INFECTION; VACUUM-ASSISTED CLOSURE; HIGH-RISK PATIENTS;
   WOUND THERAPY; MANAGEMENT-SYSTEM; CARDIAC-SURGERY; VASCULAR-SURGERY;
   CESAREAN-SECTION; MULTIVARIATE-ANALYSIS; GENERAL-SURGERY
AB Surgical site occurrences (SSOs) affect up to or over 25% of patients undergoing operative procedures, with the subset of surgical site infections (SSIs) being the most common. Commercially available closed incision negative pressure therapy (ciNPT) may offer surgeons an additional option to manage clean, closed surgical incisions. We conducted an extensive literature search for studies describing ciNPT use and assembled a diverse panel of experts to create consensus recommendations for when using ciNPT may be appropriate. A literature search of MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials using key words ' prevention ', ' negative pressure wound therapy (NPWT)', ' active incisional management ', ' incisional vacuum therapy ', ' incisional NPWT ', ' incisional wound VAC ', ' closed incisional NPWT ', ' wound infection ', and ' SSIs ' identified peer-reviewed studies published from 2000 to 2015. During a multidisciplinary consensus meeting, the 12 experts reviewed the literature, presented their own ciNPT experiences, identified risk factors for SSOs and developed comprehensive consensus recommendations. A total of 100 publications satisfied the search requirements for ciNPT use. A majority presented data supporting ciNPT use. Numerous publications reported SSI risk factors, with the most common including obesity (body mass index >= 30 kg/m(2)); diabetes mellitus; tobacco use; or prolonged surgical time. We recommend that the surgeon assess the individual patient's risk factors and surgical risks. Surgeons should consider using ciNPT for patients at high risk for developing SSOs or who are undergoing a high-risk procedure or a procedure that would have highly morbid consequences if an SSI occurred.
C1 [Willy, Christian] Bundeswehr Hosp Berlin, Res & Treatment Ctr Complex Combat Injuries, Wound Ctr Berlin, Dept Traumatol & Orthopaed Sept & Reconstruct Sur, Berlin, Germany.
   [Agarwal, Animesh] Univ Texas Hlth Sci Ctr San Antonio, Div Orthopaed Traumatol, San Antonio, TX 78229 USA.
   [Andersen, Charles A.] Madigan Army Med Ctr, Vascu Endovascu Limb Preservat Surg Serv, Tacoma, WA 98431 USA.
   [De Santis, Giorgio] Univ Modena & Reggio Emilia, Plast Reconstruct Microvascu & Aesthet Surg, Modena, Italy.
   [Gabriel, Allen] Peacehealth Med Grp, Plast Surg, Vancouver, WA USA.
   [Grauhan, Onnen] Deutsch Herzzentrum Berlin, Dept Cardiothorac & Vasc Surg, Berlin, Germany.
   [Guerra, Omar M.] Surg Suburban Surg Associates, St Louis, MO USA.
   [Lipsky, Benjamin A.] Univ Oxford, Div Med Sci, Oxford, England.
   [Malas, Mahmoud B.] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD USA.
   [Mathiesen, Lars L.] Aalborg Univ Hosp, Dept Orthopaed Surg, Aalborg, Denmark.
   [Singh, Devinder P.] Anne Arundel Med Ctr, Div Plast Surg, Annapolis, MD USA.
   [Reddy, V. Sreenath] Centennial Heart & Vasc Ctr, TriStar CV Surg, Nashville, TN USA.
C3 University of Texas System; University of Texas at San Antonio; Madigan
   Army Medical Center; Universita di Modena e Reggio Emilia; German Heart
   Center Berlin; University of Oxford; Johns Hopkins University; Aalborg
   University; Aalborg University Hospital
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Berlin, Dept Traumatol & Orthopaed Sept & Reconstruct Sur, Scharnhorststr 13, D-10115 Berlin, Germany.
EM ChristianWilly@bundeswehr.org
RI Agarwal, Animesh/AAG-5725-2020; Lipsky, Benjamin A/IZE-0823-2023; De
   Santis, Giorgio/P-9027-2016; Gabriel, Allen/AFK-3548-2022; Singh,
   Devinder/AAN-4716-2021
OI Agarwal, Animesh/0000-0003-3287-3052; Lipsky, Benjamin
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NR 121
TC 170
Z9 197
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2017
VL 14
IS 2
BP 385
EP 398
DI 10.1111/iwj.12612
PG 14
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EQ4SH
UT WOS:000398068200013
PM 27170231
OA Green Accepted, Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Danne, J
   Gwini, S
   McKenzie, D
   Danne, P
AF Danne, Julia
   Gwini, Stella
   McKenzie, Dean
   Danne, Peter
TI A Retrospective Study of Pilonidal Sinus Healing by Secondary Intention
   Using Negative Pressure Wound Therapy Versus Alginate or Gauze Dressings
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE retrospective study; wound healing; pilonidal sinus; negative pressure
   wound therapy; dressing
ID VACUUM-ASSISTED CLOSURE; DISEASE
AB Pilonidal sinus (PS) disease is an inflammatory skin and subcutaneous tissue condition that presents with infection, acute abscess, chronic discharging wounds, and/or pain. Surgery with open healing by secondary intention typically is used to achieve the fastest healing time with minimal recurrence rates. A retrospective analysis was conducted of data extracted from the medical records of 73 consecutive patients who had symptomatic natal cleft PS over a 10-year period to compare use of NPWT to alginate-based/gauze daily dressing (DD) changes in terms of healing time and recurrence. Variables extracted included age, gender, PS wound diameter (small <1 cm, medium 1 cm to 3 cm, large >3 cm), and time in weeks to achieving the endpoint (epithelialization). Risk factors examined that can affect healing or recurrence of previously operated PS disease included initial drainage before excision and risk factors for impaired healing (morbid obesity as determined by body mass index [BMI] >= 35, chronic infective skin conditions, and ongoing therapy with immuno-modulating drugs or chemotherapy), and loss to follow-up. Data were collected and analyzed using the chi-squared statistic, Kaplan-Meier curves, and Cox regression models. The total time of follow-up was 390 weeks for the DD group and 311 weeks for NPWT group. Patient mean age was 26.5 +/- 10.7 years, most (53, 72.6%) were male, and 12 (16.4%) had comorbidities potentially affecting healing. Nine (9) were treated with primary closure and 62 patients were treated with open healing by secondary intention (2 additional patients receiving DD were excluded from the analysis because they had small sinuses that made NPWT unfeasible). Among participants, 30 (48%) received DD and 32 had NPWT. The median time to healing was 10 weeks (95% CI: 7-17) in the DD group and 8 weeks (95% CI: 7-9) in the NPWT group (not significantly different). In patients who healed, the average time to healing was 15.0 +/- 18.1 and 9.8 +/- 6.3 weeks in the DD and NPWT groups, respectively (not significantly different). The PS wound recurred in 5 patients -4 (12.5%) in the DD group and 1 (3.1%) in the NPWT group (P =.355). In univariate analysis, only the presence of comorbidities was found to significantly affect time to healing (HR 95%, CI: 0.40 [0.17-0.93]; P =.033]. Prospective, randomized controlled clinical studies are warranted.
C1 [Danne, Julia] St Vincents Hosp Melbourne, Melbourne, Vic, Australia.
   [Danne, Peter] General Trauma Surgeon Epworth Healthcare, Richmond, Australia.
C3 St Vincent's Health; St Vincent's Hospital Melbourne
RP Danne, J (通讯作者)，Epworth Ctr, Suite 8,Level 8,32 Erin St, Richmond, Vic 3121, Australia.
EM juliadanne@hotmail.com
RI Gwini, Stella/AAI-8648-2021
OI Gwini, Stella/0000-0002-0295-4575
CR Al-Khamis A, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006213.pub3
   [Anonymous], MED BEN SCHED BOOK
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NR 21
TC 17
Z9 18
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAR
PY 2017
VL 63
IS 3
BP 47
EP 53
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EQ5MZ
UT WOS:000398128200003
PM 28355137
DA 2026-07-24
ER
PT J
AU Chen, BL
   Hao, FB
   Yang, Y
   Shang, QJ
   Guo, CB
AF Chen, Bailin
   Hao, Fabao
   Yang, Yang
   Shang, Qingjuan
   Guo, Chunbao
TI Prophylactic vacuum sealing drainage (VSD) in the prevention of
   postoperative surgical site infections in pediatric patients with
   contaminated laparotomy incisions
SO MEDICINE
LA English
DT Article
DE postoperative complications; surgical site infections; vacuum sealing
   drainage
ID PRESSURE WOUND THERAPY; PROTECTIVE DISC; TRANSDUCTION; INTESTINES;
   GUIDELINE; DEFECTS
AB Surgical site infection (SSI) continues to be an issue in abdominal surgery, especially for contaminated (class III) and dirty-infected (class IV) wounds. Vacuum sealing drainage (VSD) was reported effective in the management of various types of wounds or skin grafts. Our goal was to investigate the efficacy of prophylactic VSD to better orient their medicosurgical care of high-risk incisions following laparotomy in a pediatric population.
   A total of 331 pediatric patients with contaminated (class III) and dirty-infected (class IV) wounds following emergency laparotomy were retrospectively reviewed between January 2005 and January 2013. Among them, 111 cases were placed with prophylactic VSD when incisions were closed. Clinical outcomes, including, overall surgical site complication, device effectiveness, and mean postoperative LOS were evaluated based on VSD usage or not.
   VSD was applied for an average of 5.8 days (range, 5-7 days), with 3 to 15mL sucked fluid. The overall SSIs rate was 3% for patients with prophylactic VSD and 17% for patients with convention dressing (OR, 0.27; 95% CI, 0.10-0.71, P=0.004). In patients with prophylactic VSD, only 1 of 96 wound developed postoperative incision dehiscence, which is significant reduced compared with patients for conventional dressings (OR, 0.12; 95% CI, 0.01-0.95; P=0.017) (Table 2). It also exhibited a decreased mean postoperative LOS (P<0.001) for prophylactic VSD over conventional dressings.
   Our study demonstrated beneficial postoperative clinical effects of prophylactic VSD for high-risk laparotomy incisions following emergency laparotomy, such as shorter length of hospitalization, which may be attributed to the reduced overall SSIs rate.
C1 [Chen, Bailin; Hao, Fabao; Yang, Yang; Guo, Chunbao] Chongqing Med Univ, Childrens Hosp, Dept Pediat Gen Surg & Liver Transplantat, 136 Zhongshan 2nd Rd, Chongqing, Peoples R China.
   [Shang, Qingjuan] Linyi Peoples Hosp, Dept Pathol, Linyi 27600, Shandong, Peoples R China.
   [Guo, Chunbao] Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Guo, CB (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Pediat Gen Surg & Liver Transplantat, 136 Zhongshan 2nd Rd, Chongqing, Peoples R China.; Shang, QJ (通讯作者)，Linyi Peoples Hosp, Dept Pathol, Linyi 27600, Shandong, Peoples R China.
EM 236369192@qq.com; guochunbao@cqmu.edu.cn
CR [Anonymous], LANCET INFECT DIS
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NR 19
TC 13
Z9 21
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAR
PY 2017
VL 96
IS 13
AR e6511
DI 10.1097/MD.0000000000006511
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ER2EK
UT WOS:000398606800052
PM 28353606
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Or, M
   Van Goethem, B
   Kitshoff, A
   Koenraadt, A
   Schwarzkopf, I
   Bosmans, T
   de Rooster, H
AF Or, Matan
   Van Goethem, Bart
   Kitshoff, Adriaan
   Koenraadt, Annika
   Schwarzkopf, Ilona
   Bosmans, Tim
   de Rooster, Hilde
TI Negative pressure wound therapy using polyvinyl alcohol foam to bolster
   full-thickness mesh skin grafts in dogs
SO VETERINARY SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB ObjectiveTo report the use of negative pressure wound therapy (NPWT) with polyvinyl alcohol (PVA) foam to bolster full-thickness mesh skin grafts in dogs.
   Study DesignRetrospective case series.
   AnimalsClient-owned dogs (n=8).
   Material and MethodsFull-thickness mesh skin graft was directly covered with PVA foam. NPWT was maintained for 5 days (in 1 or 2 cycles). Grafts were evaluated on days 2, 5, 10, 15, and 30 for graft appearance and graft take, granulation tissue formation, and complications.
   ResultsFirm attachment of the graft to the recipient bed was accomplished in 7 dogs with granulation tissue quickly filling the mesh holes, and graft take considered excellent. One dog had bandage complications after cessation of the NPWT, causing partial graft loss. The PVA foam did not adhere to the graft or damage the surrounding skin.
   ConclusionThe application of NPWT with a PVA foam after full-thickness mesh skin grafting in dogs provides an effective method for securing skin grafts, with good graft acceptance. PVA foam can be used as a primary dressing for skin grafts, obviating the need for other interposing materials to protect the graft and the surrounding skin.
C1 [Or, Matan; Van Goethem, Bart; Kitshoff, Adriaan; Koenraadt, Annika; Schwarzkopf, Ilona; Bosmans, Tim; de Rooster, Hilde] Univ Ghent, Small Anim Dept, Fac Vet Med, Salisburylaan 133, B-9820 Merelbeke, Belgium.
   [Schwarzkopf, Ilona] DAC Malpertuus, Heusden, Belgium.
C3 Ghent University
RP Or, M (通讯作者)，Univ Ghent, Small Anim Dept, Fac Vet Med, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM matanor5@gmail.com
RI de Rooster, Hilde/AAX-9497-2020; Kitshoff, Adriaan/AFS-4979-2022; Van
   Goethem, Bart/AAM-7175-2020
OI de Rooster, Hilde/0000-0001-8087-256X; Kitshoff,
   Adriaan/0000-0001-9657-740X; 
CR [Anonymous], V A C THER CLIN GUID
   [Anonymous], V A C THER VET US US
   [Anonymous], 2011, V A C THER VET US AP
   Ben-Amotz R, 2007, VET SURG, V36, P684, DOI 10.1111/j.1532-950X.2007.00321.x
   Bohling MW, 2012, SMALL ANIMAL VET SUR, P1271
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NR 20
TC 14
Z9 16
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD APR
PY 2017
VL 46
IS 3
BP 389
EP 395
DI 10.1111/vsu.12613
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA ER3BA
UT WOS:000398668100009
PM 28151546
DA 2026-07-24
ER
PT J
AU Monsen, C
   Acosta, S
   Kumlien, C
AF Monsen, Christina
   Acosta, Stefan
   Kumlien, Christine
TI Patients experiences of negative pressure wound therapy at home for the
   treatment of deep perivascular groin infection after vascular surgery
SO JOURNAL OF CLINICAL NURSING
LA English
DT Article
DE content analysis; postoperative care; qualitative study; vascular
   disease; wound care
ID VACUUM-ASSISTED CLOSURE; QUALITY-OF-LIFE; NPWT; CARE; COMPLICATIONS;
   PREDICTORS; DISCHARGE; ALGINATE; PAIN
AB Aims and objectives. To explore experiences of negative pressure wound therapy at home, in patients with deep perivascular groin infection after vascular surgery and management in daily life.
   Background. Deep surgical site infection after vascular surgery with exposed vessels often requires long-term treatment with negative pressure wound therapy, and continued therapy at home has become routine.
   Design. An explorative qualitative study.
   Methods. Nine men and six women with a deep surgical site infection in the groin after vascular surgery, treated in their home with negative pressure wound therapy, were interviewed. The interviews were analysed using manifest and latent content analysis.
   Results. Undergoing negative pressure wound therapy at home meant a transition from being a dependent patient to a person who must have self-care competence and be involved in their own care. A need to feel prepared for this before discharge from hospital was expressed. Lack of information and feelings of uncertainty prolonged the time before feeling confident in managing the treatment. The informants gradually accepted the need to be tied up to a machine, became competent in its management and found solutions to perform everyday tasks. Overall, it was a relief to be treated at home.
   Conclusions. Several benefits of negative pressure wound therapy at home were expressed. However, unnecessary stress and anxiety were experienced due to a lack of information on the treatment and instruction concerning the equipment. Adequate information and education must therefore be provided to facilitate the transition from a patient to a person with self-care competence and ability to manage this treatment at home.
   Relevance to clinical practice. The findings revealed a need for more support and knowledge in their transition from hospital care to home care with negative pressure wound therapy. Routines must be established that ensure patient safety and security in treatment at home.
C1 [Monsen, Christina; Acosta, Stefan; Kumlien, Christine] Skane Univ Hosp, Vasc Ctr Malmo Lund, SE-20502 Malmo, Sweden.
   [Kumlien, Christine] Malmo Univ, Dept Care Sci, Malmo, Sweden.
C3 Lund University; Skane University Hospital; Malmo University
RP Monsen, C (通讯作者)，Skane Univ Hosp, Vasc Ctr Malmo Lund, SE-20502 Malmo, Sweden.
EM christina.monsen@gmail.se
RI Acosta, Stefan/JAX-3225-2023; Kumlien, Christine/ISB-5443-2023
OI Acosta, Stefan/0000-0002-3225-0798; Kumlien,
   Christine/0000-0002-1437-5060
CR [Anonymous], PLASTIC SURG INT
   [Anonymous], AM J INFECT CONTROL
   [Anonymous], THEORETICAL NURSING
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NR 35
TC 16
Z9 18
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD MAY
PY 2017
VL 26
IS 9-10
BP 1405
EP 1413
DI 10.1111/jocn.13702
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA ES1YF
UT WOS:000399322200024
PM 28001332
DA 2026-07-24
ER
PT J
AU Staruch, RMT
   Glass, GE
   Rickard, R
   Hettiaratchy, SP
   Butler, PEM
AF Staruch, Robert M. T.
   Glass, Graeme E.
   Rickard, Rory
   Hettiaratchy, Shehan P.
   Butler, Peter E. M.
TI Injectable Pore-Forming Hydrogel Scaffolds for Complex Wound Tissue
   Engineering: Designing and Controlling Their Porosity and Mechanical
   Properties
SO TISSUE ENGINEERING PART B-REVIEWS
LA English
DT Review
DE injectable; hydrogel; scaffolds; wound; mechanotransduction; NPWT
ID SUPERCRITICAL CARBON-DIOXIDE; POLY(ETHYLENE GLYCOL) HYDROGELS;
   CALCIUM-PHOSPHATE CEMENTS; VACUUM-ASSISTED CLOSURE; MESENCHYMAL
   STEM-CELL; NEGATIVE-PRESSURE; IN-VITRO; SUBSTRATE STIFFNESS; MICROSCALE
   TECHNOLOGIES; REGENERATIVE MEDICINE
AB Traumatic soft tissue wounds present a significant reconstructive challenge. The adoption of closed-circuit negative pressure wound therapy (NPWT) has enabled surgeons to temporize these wounds before reconstruction. Such systems use porous synthetic foam scaffolds as wound fillers at the interface between the negative pressure system and the wound bed. The idea of using a bespoke porous biomaterial that enhances wound healing, as filler for an NPWT system, is attractive as it circumvents concerns regarding reconstructive delay and the need for dressing changes that are features of the current systems. Porous foam biomaterials are mechanically robust and able to synthesize in situ. Hence, they exhibit potential to fulfill the niche for such a functionalized injectable material. Injectable scaffolds are currently in use for minimally invasive surgery, but the design parameters for large-volume expansive foams remain unclear. Potential platforms include hydrogel systems, (particularly superabsorbent, superporous, and nanocomposite systems), polyurethane-based moisture-cured foams, and high internal phase emulsion polymer systems. The aim of this review is to discuss the design parameters for such future biomaterials and review potential candidate materials for further research into this up and coming field.
C1 [Staruch, Robert M. T.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
   [Glass, Graeme E.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
   [Rickard, Rory] Acad Dept Mil Surg & Trauma, ICT Business Pk, Birmingham, W Midlands, England.
   [Hettiaratchy, Shehan P.] St Marys Hosp, London, England.
   [Hettiaratchy, Shehan P.] Imperial Coll NHS Trust, London, England.
   [Butler, Peter E. M.] UCL, Royal Free Hosp, Dept Surg & Intervent Sci, London, England.
C3 Harvard University; University of Oxford; Imperial College London;
   University of London; University College London; Royal Free London NHS
   Foundation Trust; UCL Medical School
RP Staruch, RMT (通讯作者)，Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
EM robmtstaruch@doctors.org.uk
RI Glass, Graeme/I-7011-2019
OI Butler, Peter/0000-0001-7419-1493; Staruch, Robert/0000-0003-1718-2341
FU Academy of Medical Sciences (AMS) [AMS-SGCL6-Glass] Funding Source:
   researchfish
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NR 160
TC 47
Z9 56
U1 3
U2 217
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3368
EI 1937-3376
J9 TISSUE ENG PART B-RE
JI Tissue Eng. Part B-Rev.
PD APR
PY 2017
VL 23
IS 2
BP 183
EP 198
DI 10.1089/ten.teb.2016.0305
PG 16
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
   Biology; Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Biotechnology & Applied Microbiology; Engineering;
   Materials Science
GA ES2AB
UT WOS:000399327000007
PM 27824295
DA 2026-07-24
ER
PT J
AU Webb, LX
AF Webb, Lawrence X.
TI The Impact of Negative Pressure Wound Therapy on Orthopaedic Infection
SO ORTHOPEDIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Negative pressure wound therapy; Topical negative pressure; Surgical
   site infection; Quorum sensing; Tissue demarcation; Integra; Antibiotic
   beads; Wound coverage
ID MECHANICAL TISSUE RESUSCITATION; VACUUM-ASSISTED CLOSURE;
   ISCHEMIA-REPERFUSION INJURY; SUBATMOSPHERIC PRESSURE; SEALING-TECHNIQUE;
   OPEN FRACTURES; SKIN; FOUNDATION; TRAUMA; SYSTEM
AB By hastening the resolution of edema and improving local microcirculation, topical negative pressure wound therapy (TNP) aids the establishment of early wound coverage. Its use in the setting of type Ill open fractures is reviewed. The author's initial use of TNP for closed surgical incisions and how it morphed its way into being applied to closed surgical wounds with heightened likelihood for infection is presented. Several case studies are presented to illustrate the role and the technique for management of acute or subacute infections involving bone and implant.
C1 [Webb, Lawrence X.] Med Ctr Navicent Hlth, Dept Orthopaed Trauma, 840 Pine St,Suite 500, Macon, GA 31201 USA.
   [Webb, Lawrence X.] Mercer Univ, Dept Surg, Sch Med, 1400 Coleman Ave, Macon, GA 31217 USA.
   [Webb, Lawrence X.] Wake Forest Univ, Dept Orthopaed Surg, Med Ctr, Med Ctr Blvd, Winston Salem, NC 27157 USA.
C3 Mercer University; Wake Forest University
RP Webb, LX (通讯作者)，Med Ctr Navicent Hlth, Dept Orthopaed Trauma, 840 Pine St,Suite 500, Macon, GA 31201 USA.; Webb, LX (通讯作者)，Mercer Univ, Dept Surg, Sch Med, 1400 Coleman Ave, Macon, GA 31217 USA.; Webb, LX (通讯作者)，Wake Forest Univ, Dept Orthopaed Surg, Med Ctr, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM Webb.Lawrence@navicenthealth.org
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NR 49
TC 15
Z9 17
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0030-5898
EI 1558-1373
J9 ORTHOP CLIN N AM
JI Orthop. Clin. North Am.
PD APR
PY 2017
VL 48
IS 2
BP 167
EP +
DI 10.1016/j.ocl.2016.12.004
PG 14
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA ES5ZX
UT WOS:000399626600007
PM 28336040
DA 2026-07-24
ER
PT J
AU Liu, S
   He, CZ
   Cai, YT
   Xing, QP
   Guo, YZ
   Chen, ZL
   Su, JL
   Yang, LP
AF Liu, Si
   He, Chao-zhu
   Cai, Yan-ting
   Xing, Qiu-ping
   Guo, Ying-zhen
   Chen, Zhi-long
   Su, Ji-liang
   Yang, Li-ping
TI Evaluation of negative-pressure wound therapy for patients with diabetic
   foot ulcers: systematic review and meta-analysis
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Review
DE diabetic foot ulcers; negative-pressure wound therapy; complete wound
   closure; amputation; meta-analysis; cost-effectiveness
ID VACUUM-ASSISTED CLOSURE; AMPUTATION; MULTICENTER; DRESSINGS
AB Objectives: The aim of this study was to perform an updated systematic review and meta-analysis to assess the clinical efficacy, safety, and cost-effectiveness of negative-pressure wound therapy (NPWT) in the treatment of diabetic foot ulcers (DFUs).
   Methods: We searched the Cochrane Library, MEDLINE, EMBASE, Ovid, and Chinese Biological Medicine databases up to June 30, 2016. We also manually searched the articles from reference lists of the retrieved articles, which used the NPWT system in studies of vacuumassisted closure therapy. Studies were identified and selected, and two independent reviewers extracted data from the studies.
   Results: A total of eleven randomized controlled trials, which included a total of 1,044 patients, were selected from 691 identified studies. Compared with standard dressing changes, NPWT had a higher rate of complete healing of ulcers (relative risk, 1.48; 95% confidence interval [CI]: 1.24-1.76; P<0.001), shorter healing time (mean difference, -8.07; 95% CI: -13.70-2.45; P=0.005), greater reduction in ulcer area (mean difference, 12.18; 95% CI: 8.50-15.86; P<0.00001), greater reduction in ulcer depth (mean difference, 40.82; 95% CI: 35.97-45.67; P<0.00001), fewer amputations (relative risk, 0.31; 95% CI: 0.15-0.62; P=0.001), and no effect on the incidence of treatment-related adverse effects (relative risk, 1.12; 95% CI: 0.66-1.89; P=0.68). Meanwhile, many analyses showed that the NPWT was more cost-effective than standard dressing changes.
   Conclusion: These results indicate that NPWT is efficacious, safe, and cost-effective in treating DFUs.
C1 [Liu, Si; He, Chao-zhu; Cai, Yan-ting; Xing, Qiu-ping; Guo, Ying-zhen; Chen, Zhi-long; Su, Ji-liang] Nanchang Univ, Sch Nursing, Ba Yi Rd, Nanchang 330006, Jiangxi, Peoples R China.
   [Yang, Li-ping] Nanchang Univ, Affiliated Hosp 2, Dept Endocrinol, Nanchang, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University
RP He, CZ (通讯作者)，Nanchang Univ, Sch Nursing, Ba Yi Rd, Nanchang 330006, Jiangxi, Peoples R China.
EM 1028970010@qq.com
RI Liu, Si/POY-6077-2026
CR Al-Rubeaan K, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124446
   Alavi A, 2014, J AM ACAD DERMATOL, V70, DOI 10.1016/j.jaad.2013.06.055
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NR 35
TC 117
Z9 140
U1 1
U2 35
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2017
VL 13
DI 10.2147/TCRM.S131193
PG 12
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA ES8JQ
UT WOS:000399803700002
PM 28458556
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mushin, OP
   Bogue, JT
   Esquenazi, MD
   Toscano, N
   Bell, DE
AF Mushin, Oren P.
   Bogue, Jarrod T.
   Esquenazi, Mica D.
   Toscano, Nicole
   Bell, Derek E.
TI Use of a home vacuum-assisted closure device in the burn population is
   both cost-effective and efficacious
SO BURNS
LA English
DT Article
DE Skin graft; Vacuum assisted closure device; VAC; Home VAC; hVAC;
   Negative pressure wound therapy
ID RANDOMIZED CONTROLLED-TRIAL; THICKNESS SKIN-GRAFTS; THERAPY; CARE
AB Introduction: The vacuum assisted closure device (VAC) improves wound-healing when utilized as a bolster to secure split thickness skin grafts (STSG). Patients typically remain hospitalized for VAC therapy; however, home VACs (hVAC) are now available. Limited studies examine burns treated with hVAC as a STSG bolster.
   Method: A retrospective study of records from an ABA verified regional burn center was conducted over 23 months. Patients included STSGs for burn. Data points included demographics, burn mechanism and location, graft characteristics, hospital length of stay (LOS), and time to heal.
   Results and discussion: Fifty patients were included, with average age of 39 years (range <1-83 years). Average burn TBSA was 1.27 +/- 1.42 (range 0.05-8.18). Grafted area average was 102.9 +/- 128.1cm(2). The most commonly treated areas were the leg/foot, thigh, and torso (53%, 16%, and 16%, respectively). Average LOS was 1.1 +/- 1.2 days. Mean graft-take was 99.2 +/- 2.8% with one patient undergoing repeat STSG. Average post-operative time to heal was 16 +/- 6 days. A 5-day inpatient stay with a VAC costs an average of $34,635, compared to $9134 for an hVAC over the same period.
   Conclusions: The hVAC is a cost-effective STSG bolster in the burn population for appropriate candidates. Excellent graft-take and low morbidity rates imply that this is an efficacious alternative for STSG bolster. (C) 2016 Elsevier Ltd and ISBI. All rights reserved.
C1 [Mushin, Oren P.; Bogue, Jarrod T.; Esquenazi, Mica D.; Toscano, Nicole; Bell, Derek E.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA.
C3 University of Rochester
RP Bell, DE (通讯作者)，Univ Rochester, Strong Mem Hosp, Med Ctr, Dept Surg, 601 Elmwood Ave,Box SURG, Rochester, NY 14642 USA.
EM Derek_Bell@urmc.rochester.edu
RI Bogue, Jarrod/KBA-0778-2024
CR [Anonymous], WEIGHT NAT EST HCUP
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NR 17
TC 10
Z9 10
U1 1
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAY
PY 2017
VL 43
IS 3
BP 490
EP 494
DI 10.1016/j.burns.2016.08.038
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA ES9GD
UT WOS:000399863500005
PM 28256293
DA 2026-07-24
ER
PT J
AU Liu, JY
   Hu, F
   Tang, JT
   Tang, SJ
   Xia, K
   Wu, S
   Yin, CQ
   Wang, SH
   He, QY
   Xie, HQ
   Zhou, JD
AF Liu, Jinyan
   Hu, Feng
   Tang, Jintian
   Tang, Shijie
   Xia, Kun
   Wu, Song
   Yin, Chaoqi
   Wang, Shaohua
   He, Quanyong
   Xie, Huiqing
   Zhou, Jianda
TI Homemade-device-induced negative pressure promotes wound healing more
   efficiently than VSD-induced positive pressure by regulating
   inflammation, proliferation and remodeling
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE wound healing; negative pressure; cell infiltration; positive pressure;
   vacuum sealing drainage; growth factor; inflammation; extracellular
   matrix
ID VACUUM-ASSISTED CLOSURE; STEM-CELLS; THERAPY; STATE
AB Vacuum sealing drainage (VSD) is an effective technique used to promote wound healing. However, recent studies have shown that it exerts positive pressure (PP) rather than negative pressure (NP) on skin. In this study, we created a homemade device that could maintain NP on the wound, and compared the therapeutic effects of VSD-induced PP to those of our home-made device which induced NP on wound healing. The NP induced by our device required less time for wound healing and decreased the wound area more efficiently than the PP induced by VSD. NP and PP both promoted the inflammatory response by upregulating neutrophil infiltration and interleukin (IL)-1 expression, and downregulating IL-10 expression. Higher levels of epidermal growth factor (EGF), transforming growth factor (TGF)- and platelet-derived growth factor (PDGF), and lower levels of basic fibroblast growth factor (bFGF) were observed in the wound tissue treated with NP compared to the wound tissue exposed to PP. Proliferation in the wound tissue exposed to NP on day 10 was significantly higher than that in wound tissue exposed to PP. NP generated more fibroblasts, keratinized stratified epithelium, and less epithelia with stemness than PP. The levels of ccollagen I and III were both decreased in both the NP and PP groups. NP induced a statistically significant increase in the expression of fibronectin (FN) on days 3 and 10 compared to PP. Furthermore, the level of matrix metalloproteinase (MMP)-13 increased in the NP group, but decreased in the PP group on day 3. NP also induced a decrease in the levels of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 during the early stages of wound healing, which was significantly different from the increasing effect of PP on TIMP-1 and TIMP-2 levels at the corresponding time points. On the whole, our data indicate that our homemade device which induced NP, was more efficient than VSD-induced PP on wound healing by regulating inflammation, secretion, proliferation and the distribution of different cells in wound tissue.
C1 [Liu, Jinyan] Cent S Univ, Xiangya Hosp 1, Dept Nucl Med, Changsha 410008, Hunan, Peoples R China.
   [Hu, Feng; Yin, Chaoqi; Wang, Shaohua; He, Quanyong; Zhou, Jianda] Cent S Univ, Xiangya Hosp 3, Dept Plast Surg, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.
   [Tang, Jintian] Tsinghua Univ, Inst Med Phys & Engn, Beijing 100084, Peoples R China.
   [Tang, Shijie] Shantou Univ, Coll Med, Affiliated Hosp 2, Cleft Lip & Palate Treatment Ctr, Shantou 515041, Guangdong, Peoples R China.
   [Xia, Kun] Cent S Univ, Key Lab Med Informat Res, Changsha, Hunan, Peoples R China.
   [Wu, Song] Cent S Univ, Xiangya Hosp 3, Dept Orthoped, Changsha 410013, Hunan, Peoples R China.
   [Xie, Huiqing] Cent S Univ, Xiangya Hosp 3, Dept Rehabil Med, Changsha 410013, Hunan, Peoples R China.
C3 Central South University; Central South University; Tsinghua University;
   Shantou University; Central South University; Central South University;
   Central South University
RP Zhou, JD (通讯作者)，Cent S Univ, Xiangya Hosp 3, Dept Plast Surg, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.
EM zhoujianda_csu@163.com
FU Key Projects of the Fund of Science and Technology Department of Hunan
   Province [2014SK2018]; Scientific Research Fund of the Health Department
   of Hunan Province [132013-026]
FX This study was supported by the Key Projects of the Fund of Science and
   Technology Department of Hunan Province (2014SK2018) and the Scientific
   Research Fund of the Health Department of Hunan Province (132013-026).
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NR 27
TC 14
Z9 23
U1 1
U2 18
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD APR
PY 2017
VL 39
IS 4
BP 879
EP 888
DI 10.3892/ijmm.2017.2919
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA ES9XK
UT WOS:000399915100012
PM 28290607
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Schipper, P
   Tieu, BH
AF Schipper, Paul
   Tieu, Brandon H.
TI Acute Chest Wall Infections Surgical Site Infections, Necrotizing Soft
   Tissue Infections, and Sternoclavicular Joint Infection
SO THORACIC SURGERY CLINICS
LA English
DT Article
DE Surgical site infections; SSI; Wound infection; Necrotizing soft tissue
   infection; Necrotizing fasciitis; Sternoclavicular joint infection;
   Sternoclavicular pyoarthrosis
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE COMPLICATIONS; SMOKING-CESSATION;
   LUNG-CANCER; INTRATHORACIC APPLICATION; NEGATIVE-PRESSURE; MANAGEMENT;
   THERAPY; RESECTION; EMPYEMA
AB Acute chest wall infections are uncommon and share similar risk factors for infection at other surgical sites. Smoking cessation has been shown to decrease the risk of surgical site infection. Depending on the depth of infection and/or involvement of the organ space, adequate therapy involves antibiotics and drainage. Early diagnosis and debridement of necrotizing soft tissue infections is essential to reduce mortality. Sternoclavicular joint infections require surgical debridement, en bloc resection, and antibiotic therapy. A standard approach to wound closure after resection has yet to be established. Vacuum-assisted closure is a valuable adjunct to standard therapy.
C1 [Schipper, Paul; Tieu, Brandon H.] Oregon Hlth & Sci Univ, Dept Surg, Div Cardiothorac Surg, Sect Gen Thorac Surg, 3181 SW Sam Jackson Pk Rd L353, Portland, OR 97239 USA.
C3 Oregon Health & Science University
RP Schipper, P (通讯作者)，Oregon Hlth & Sci Univ, Dept Surg, Div Cardiothorac Surg, Sect Gen Thorac Surg, 3181 SW Sam Jackson Pk Rd L353, Portland, OR 97239 USA.
EM schippep@ohsu.edu
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NR 44
TC 9
Z9 14
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1547-4127
J9 THORAC SURG CLIN
JI Thorac. Surg. Clin.
PD MAY
PY 2017
VL 27
IS 2
BP 73
EP +
DI 10.1016/j.thorsurg.2017.01.001
PG 15
WC Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System; Surgery
GA ET6QE
UT WOS:000400415700002
PM 28363376
DA 2026-07-24
ER
PT J
AU Niu, XF
   Yi, JH
   Zha, GQ
   Hu, J
   Liu, YJ
   Xiao, LB
AF Niu, X. -F.
   Yi, J. -H.
   Zha, G. -Q.
   Hu, J.
   Liu, Y. -J.
   Xiao, L. -B.
TI Vacuum sealing drainage as a pre-surgical adjunct in the treatment of
   complex (open) hand injuries: Report of 17 cases
SO ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
LA English
DT Article
DE Vacuum sealing drainage; Pre-surgical adjunct; Complex (open) hand
   injuries; Wound preparation
ID PRESSURE WOUND THERAPY; SOFT-TISSUE DEFECTS; ASSISTED CLOSURE; COST
AB Background: Few studies have been conducted to explore the use of the vacuum sealing drainage (VSD) technique in complex hand injuries. The aim of this study was to report outcomes in patients with complex hand injuries receiving VSD as a coadjuvant treatment prior to second-stage surgery.
   Methods: This case series study retrospectively reviewed the patients who underwent VSD for treatment of hand injuries. Inclusion criteria for the study were: (1) traumatic soft tissue defects of the hand and wrist, accompanied by different degrees of injury and exposure of bone, tendon, or blood vessel; (2) the wound surface of hand and wrist was seriously contaminated and direct wound closure was not possible; and (3) the soft tissues of hand and wrist were seriously lacerated or avulsed, and showed necrosis or acute infection. After debridement, one-stage and/or two-stage repairs using healthy adjacent tissues were performed and the wound was covered by the VSD materials. The non-cytotoxic polyethylene alcohol hydration seaweed salt foam was applied during the VSD treatment for its good biocompatibility. The drainage tube was connected to the vacuum equipment and the negative pressures were set at -60 kPa to -40 kPa. The VSD device was left in place for 5 to 7 days before removal. Either free skin grafting or skin flap transplantation was used for wound closure and/or reconstructive surgery. The hand injury severity score was used to assess wound severity. The surgical results were scored using the total active motion classification.
   Results: A total of 17 patients (13 and 4 patients had major and severe hand injuries), averaging 33.8 years were included. During the study period, 6 patients with severe hand injuries were not treated with VSD for the following reasons: (1) hemodynamic instability (n = 1); (2) impaired coagulation function (n = 1); (3) uncontrollable hemorrhage on the wound surface (n = 2); and (4) exposure of the main blood vessels after surgical repair (n = 2). VSD treatment was performed for an average of 7.4 days (range, 6-14 days) and the duration of wound healing averaged 23 days (range, 20-43 days). Wound infection was not reported prior to second-stage surgery. Only one of 17 patients had superficial necrosis at the flap edge, for a success rate of 94%. Average follow-up was 8.7 months (range, 4-13 months). Twelve (71%) patients reported excellent or good, four (23%) reported fair, and one (6%) reported poor results.
   Conclusion: The VSD can effectively promote safe and rapid repair of local soft tissues with good prognosis. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Niu, X. -F.; Yi, J. -H.; Zha, G. -Q.; Hu, J.; Liu, Y. -J.; Xiao, L. -B.] Sun Yat Sen Univ, Affiliated Hosp 1, Eastern Hosp, Dept Upper Extrem Orthoped, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Xiao, LB (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Eastern Hosp, Dept Upper Extrem Orthoped, Guangzhou 510080, Guangdong, Peoples R China.
EM gz20080316@163.com
CR Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Buchanan PJ, 2014, PLAST RECONSTR SURG, V134, P1391, DOI 10.1097/PRS.0000000000000720
   Campbell DA, 1996, J HAND SURG-BRIT EUR, V21B, P295, DOI 10.1016/S0266-7681(05)80187-1
   Cheema TA, 2014, COMPLEX INJURIES HAN
   Chen KD, 1999, J BIOL CHEM, V274, P18393, DOI 10.1074/jbc.274.26.18393
   Chen Shao-zong, 2005, Zhonghua Zheng Xing Wai Ke Za Zhi, V21, P197
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Hasegawa K, 2013, ACTA MED OKAYAMA, V67, P271
   Hellmich S, 2014, TRAUMA SURG, P139
   Kamolz LP, 2004, BURNS, V30, P253, DOI 10.1016/j.burns.2003.12.003
   Kaplan M, 2009, ADV SKIN WOUND CARE, V22, P128, DOI 10.1097/01.ASW.0000305451.71811.d5
   Kasukurthi Rahul, 2010, Hand (N Y), V5, P95, DOI 10.1007/s11552-009-9209-4
   KLEINERT HE, 1983, J HAND SURG-AM, V8, P794, DOI 10.1016/S0363-5023(83)80275-5
   Li RG, 2012, INJURY, V43, P822, DOI 10.1016/j.injury.2011.09.031
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Sahin I, 2012, Ann Burns Fire Disasters, V25, P92
   Silver Frederick H, 2003, Crit Rev Biomed Eng, V31, P255, DOI 10.1615/CritRevBiomedEng.v31.i4.10
   The Orthopaeidc Unit October 6 University Cairo Egypt, 2015, International Journal of Bone and Rheumatology Research, P8, DOI 10.19070/2470-4520-150002
   Trybus M, 2006, AM J SURG, V192, P52, DOI 10.1016/j.amjsurg.2005.10.055
   Uhl RL, 2013, ORTHOPEDICS, V36, P773, DOI 10.3928/01477447-20130920-05
   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
   Yao Yuan-zhang, 2002, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V16, P388
   Yu GR, 2007, TISSUE ENG, V13, P1387
   Zachary I, 2001, CARDIOVASC RES, V49, P568, DOI 10.1016/S0008-6363(00)00268-6
NR 24
TC 13
Z9 25
U1 0
U2 10
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1877-0568
J9 ORTHOP TRAUMATOL-SUR
JI Orthop. Traumatol.-Surg. Res.
PD MAY
PY 2017
VL 103
IS 3
BP 461
EP 464
DI 10.1016/j.otsr.2017.01.008
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA ET6TK
UT WOS:000400425100026
PM 28274882
DA 2026-07-24
ER
PT J
AU Wang, T
   He, R
   Zhao, J
   Mei, JC
   Shao, MZ
   Pan, Y
   Zhang, J
   Wu, HS
   Yu, M
   Yan, WC
   Liu, LM
   Liu, F
   Jia, WP
AF Wang, T.
   He, R.
   Zhao, J.
   Mei, J. C.
   Shao, M. Z.
   Pan, Y.
   Zhang, J.
   Wu, H. S.
   Yu, M.
   Yan, W. C.
   Liu, L. M.
   Liu, F.
   Jia, W. P.
TI Negative pressure wound therapy inhibits inflammation and upregulates
   activating transcription factor-3 and downregulates nuclear factor-B in
   diabetic patients with foot ulcerations
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE ATF-3; diabetic foot; inflammation; negative pressure wound therapy;
   nuclear factor-B
ID NECROSIS-FACTOR-ALPHA; NITRIC-OXIDE; MULTICENTER; MECHANISMS; RESPONSES;
   PATHWAYS; BINDING; ULCERS
AB BackgroundNegative pressure wound therapy (NPWT) is one of the most important treatments for diabetic foot, but the underlying mechanisms of its benefits still remain elusive. This study aims to evaluate the inflammatory signals involved in the effects of negative pressure therapy on diabetic foot ulcers.
   MethodsWe enrolled 22 patients with diabetic foot ulceration, 11 treated with NPWT and the other 11 treated with traditional debridement. All patients were treated and observed for 1week. Granulation tissues were harvested and analyzed in both groups, and then were histologically and immunohistochemically analyzed. Enzyme-linked immunosorbent assay, Western blot analysis, and real-time PCR were performed to evaluate the expression of interleukin-6 (IL-6), tumor necrosis factor (TNF-), inducible nitric oxide synthase (iNOS), nuclear factor-B (NF-B) p65, IkB-, and activating transcription factor-3 (ATF-3).
   ResultsAfter 7days of treatment, NPWT could obviously promote diabetic wound healing because of the mild inflammation and the dense cell-deposited matrix. Meanwhile, NPWT significantly decreased the expression of TNF-, IL-6, and iNOS (all P<.05). The result of Western blotting and real-time PCR indicated that NPWT obviously decreased the level of IkB- and NF-B p65, and increased the level of ATF-3 (all P<.05).
   ConclusionNPWT exerts an anti-inflammatory effect, possibly through the suppression of proinflammatory enzymes and cytokines resulting from IkB- inhibition and ATF-3 activation, which may prevent the activation of the NF-B pathway in human diabetic foot wounds.
C1 [Wang, T.; Zhao, J.; Mei, J. C.; Shao, M. Z.; Pan, Y.; Zhang, J.; Wu, H. S.; Yu, M.; Yan, W. C.] Shanghai Jiao Tong Univ, Multidisciplinary Collaborat Ctr Diabet Foot, Shanghai Clin Med Ctr Diabet, Affiliated Peoples Hosp Shanghai 6,Dept Vasc Surg, 600 Yishan Rd, Shanghai 200233, Peoples R China.
   [He, R.; Liu, L. M.; Liu, F.; Jia, W. P.] Shanghai Jiao Tong Univ, Shanghai Clin Med Ctr Diabet,Shanghai Inst Diabet, Shanghai Key Clin Ctr Metab Dis,Affiliated People, Multidisciplinary Collaborat Grp Diabet Foot,Dept, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Zhao, J (通讯作者)，Shanghai Jiao Tong Univ, Multidisciplinary Collaborat Ctr Diabet Foot, Shanghai Clin Med Ctr Diabet, Affiliated Peoples Hosp Shanghai 6,Dept Vasc Surg, 600 Yishan Rd, Shanghai 200233, Peoples R China.; Liu, F (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Clin Med Ctr Diabet,Shanghai Inst Diabet, Shanghai Key Clin Ctr Metab Dis,Affiliated People, Multidisciplinary Collaborat Grp Diabet Foot,Dept, Shanghai, Peoples R China.
EM junnzhao@126.com; f-liu@sjtu.edu.cn
RI 刘, 峰/KBA-6391-2024; He, Ruijia/MZQ-2297-2025; Jia, Weiping/B-7483-2012
OI Jia, Weiping/0000-0002-6244-2168
FU Natural Science Foundation of China [81270397]; Shanghai Health Bureau
   [201344197]
FX Natural Science Foundation of China, Grant/ Award Number: 81270397;
   Shanghai Health Bureau, Grant/Award Number: 201344197
CR Anwar MA, 2015, SCI REP-UK, V5, DOI 10.1038/srep07657
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Banwell P E, 2003, J Wound Care, V12, P22
   Barinov E F, 2010, Klin Khir, P40
   Basith S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054178
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   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
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   Falanga V, 2005, LANCET, V366, P1736, DOI 10.1016/S0140-6736(05)67700-8
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   Sepúlveda G, 2009, CIR ESPAN, V86, P171, DOI 10.1016/j.ciresp.2009.03.020
   Takeuchi O, 2010, CELL, V140, P805, DOI 10.1016/j.cell.2010.01.022
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NR 29
TC 32
Z9 32
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAY
PY 2017
VL 33
IS 4
AR e2871
DI 10.1002/dmrr.2871
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ET8VO
UT WOS:000400581600005
DA 2026-07-24
ER
PT J
AU Reider, KE
AF Reider, Kersten E.
TI Fistula Isolation and the Use of Negative Pressure to Promote Wound
   Healing A Case Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Collapsible fistula isolation device; Enteroatmospheric fistula; Fistula
   isolation; Negative-pressure wound therapy
ID ENTEROATMOSPHERIC FISTULAS
AB BACKGROUND: A 54-year-old morbidly obese woman with a small bowel obstruction and large ventral hernia was admitted to hospital. She underwent an exploratory laparotomy, lysis of adhesions, and ventral hernia repair with mesh placement. She subsequently developed an enteroatmospheric fistula; several months of hospital care was required to effectively manage the wound and contain effluent from the fistula.
   METHODS: Several approaches were used to manage output from the fistula during her hospital course. She was initially discharged to a skilled nursing facility where a fistula management pouch was used for several months to encompass the wound and contain effluent, but this method ultimately proved ineffective. The fistula was then isolated using a collapsible enteroatmospheric fistula isolation device and an ostomy appliance to contain effluent.
   CONCLUSION: The application of the collapsible enteroatmospheric fistula isolation and effluent containment devices in conjunction with negative-pressure wound therapy produced positive patient outcomes; it improved patient satisfaction with fistula management, promoted wound healing, and diminished cost.
C1 [Reider, Kersten E.] Reading Hlth Syst, 6th Ave & Spruce St, W Reading, PA 19611 USA.
RP Reider, KE (通讯作者)，Reading Hlth Syst, 6th Ave & Spruce St, W Reading, PA 19611 USA.
EM Kersten.reider@readinghealth.org
CR Becker HP, 2007, SCAND J SURG, V96, P263, DOI 10.1177/145749690709600402
   Brindle CT, 2009, J WOUND OSTOMY CONT, V36, P396, DOI 10.1097/WON.0b013e3181aaf2b0
   Heineman JT, 2015, J AM COLL SURGEONS, V221, pE7, DOI 10.1016/j.jamcollsurg.2015.04.015
   Hoeflok J, 2009, J WOUND OSTOMY CONT, V43, P607
   Majercik S, 2012, NUTR CLIN PRACT, V27, P507, DOI 10.1177/0884533612444541
   Schecter WP, 2009, ACS, V209, P484, DOI DOI 10.1016/J.JAMC0LLSURG.2009.05.025]
   Terzi C, 2014, INT WOUND J, V11, P17, DOI 10.1111/iwj.12288
   Timmons J, 2014, INT WOUND J, V11, P723, DOI 10.1111/iwj.12038
NR 8
TC 4
Z9 5
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2017
VL 44
IS 3
BP 293
EP 298
DI 10.1097/WON.0000000000000329
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA EU3JM
UT WOS:000400925300013
PM 28472817
DA 2026-07-24
ER
PT J
AU Matiasek, J
   Domig, KJ
   Djedovic, G
   Babeluk, R
   Assadian, O
AF Matiasek, J.
   Domig, K. J.
   Djedovic, G.
   Babeluk, R.
   Assadian, O.
TI The effect of negative pressure wound therapy with antibacterial
   dressings or antiseptics on an in vitro wound model
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE NPWTi; wound colonisation; silver; polyhexanide; octenidine; negative
   pressure wound therapy
ID ANTIMICROBIAL SOLUTIONS; INSTILLATION; MANAGEMENT; OCTENIDINE; SYSTEM;
   CHLORHEXIDINE; POLIHEXANIDE; IRRIGATION; INFECTIONS; EFFICACY
AB Objective: The aim of this study was to investigate the bacterial bioburden in experimental in vitro wounds during the application of conventional negative pressure wound therapy (NPWT), with and without antimicrobial dressings (polyhexanide, silver), against NPWT instillation of octenidine.
   Method: Experimental wounds produced in an in vitro porcine wound model were homogenously contaminated with bacterial suspension and treated with NPWT and different options. Group A: non-antimicrobial polyurethane foam dressing; group B: antimicrobial polyurethane foam dressing containing silver; group C: antimicrobial gauze dressing containing polyhexanide; group D: non-antimicrobial polyurethane foam dressing intermittently irrigated with octenidine; group E: negative control (non-antimicrobial polyurethane foam dressing without NPWT). Standard biopsies were harvested after 24 and 28 hours.
   Results: This study demonstrated that the use of NPWT with intermitted instillation of octenidine (group D) or application of silver-based polyurethane foam dressings (group B) is significantly superior against Staphylococcus aureus colonisation in experimental wounds compared with non-antimicrobial polyurethane foam dressing (group A) after 48 hours. Surprisingly, the polyhexanide-based dressing (group C) used in this model showed no statistical significant effect compared with the control group (group E) after 24 or 48 hours of treatment.
   Conclusion: Both intermitted instillation of octenidine and silver-based dressings in standard NPWT were significantly superior compared with non-antimicrobial polyurethane foam dressings or PHMB coated gauze dressing after 48 hours.
C1 [Matiasek, J.] St Josef Hosp, Dept Plast Aesthet & Reconstruct Surg, Vienna, Austria.
   [Domig, K. J.] BOKU Univ Nat Resources & Life Sci Vienna, Dept Food Sci & Technol, Vienna, Austria.
   [Djedovic, G.] Med Univ Innsbruck, Dept Plast Reconstruct & Aesthet Surg, Innsbruck, Austria.
   [Babeluk, R.] Med Univ Vienna, Dept Surg, Vienna, Austria.
   [Assadian, O.] Med Univ Vienna, Dept Hosp Epidemiol & Infect Control, Vienna, Austria.
C3 BOKU University; Medical University of Innsbruck; Medical University of
   Vienna; Medical University of Vienna
RP Matiasek, J (通讯作者)，St Josef Hosp, Dept Plast Aesthet & Reconstruct Surg, Vienna, Austria.
EM office@matiasek.com
RI Assadian, Ojan/H-9753-2019; Domig, Konrad J/A-6877-2019
OI Domig, Konrad J/0000-0003-1090-4284
CR [Anonymous], 2013, 68881200312 BS EN IS
   Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Assadian O, 2010, INT WOUND J, V7, P283, DOI 10.1111/j.1742-481X.2010.00686.x
   Back DA, 2013, INT WOUND J, V10, P32, DOI 10.1111/iwj.12183
   Clarridge JE, 2004, CLIN MICROBIOL REV, V17, P840, DOI 10.1128/CMR.17.4.840-862.2004
   Daeschlein G, 2013, INT WOUND J, V10, P9, DOI 10.1111/iwj.12175
   Dale AP, 2015, CURR OPIN INFECT DIS, V28, P151, DOI 10.1097/QCO.0000000000000146
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   Dissemond J, 2011, SKIN PHARMACOL PHYS, V24, P245, DOI 10.1159/000327210
   Ellenrieder M, 2015, SURG INFECT, V16, P139, DOI 10.1089/sur.2013.268
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   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Phillips PL, 2013, INT WOUND J, V10, P48, DOI 10.1111/iwj.12180
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NR 28
TC 5
Z9 9
U1 0
U2 24
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2017
VL 26
IS 5
BP 236
EP 242
DI 10.12968/jowc.2017.26.5.236
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EU3QD
UT WOS:000400945200005
PM 28475440
DA 2026-07-24
ER
PT J
AU Jha, RK
   Xia, CY
   Li, ZH
   Wang, WY
   Deng, K
AF Jha, Ramesh Kumar
   Xia, Chengyan
   Li, Zonghuan
   Wang, Weiyang
   Deng, Kai
TI Combined negative pressure wound therapy with open bone graft for
   infected wounds with bone defects: An experimental study
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Bone and soft-tissue defect; bone graft; infected wound; negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; ENDOTHELIAL GROWTH-FACTOR; FRACTURES; MECHANISM
AB Background: Bone and soft-tissue defects in infected wound have been an intractable problem to many surgical consultations. Infected wounds with bone defects are physical and financial burden to society. Nowadays, infected wounds with compound defect of bone and soft tissues are common in orthopedics department. Currently, no simple and efficient treatment has been found to solve this problem. This study investigates the effects of combining negative pressure wound therapy (NPWT) with open bone graft on this focus.
   Materials and Methods: Twenty four rabbits with bone and soft tissue defects accompanied infected wounds were randomized into experimental (combined NPWT with open bone graft) and contrast group (only open bone graft). Treatment efficacy was assessed by the wound condition; wound healing time, bacterial bioburden, and bony callus were evaluated by X-ray. Furthermore, samples of granulation tissue from wounds on the 3rd, 7th, and 14th days of healing were evaluated for blood vessels and expression of vascular endothelial growth factor.
   Results: Wounds in the experimental group tended to have shorter healing time, healthier wound conditions, lower bacterial bioburden, better bony callus, and more blood supply than those in the controlled group.
   Conclusions: In conclusion, NPWT combined open bone graft can act as a feasible and valuable method to treat combined infected bone and soft-tissue defects.
C1 [Jha, Ramesh Kumar; Xia, Chengyan; Li, Zonghuan; Wang, Weiyang; Deng, Kai] Wuhan Univ, Dept Orthopaed, Zhongnan Hosp, Wuhan, Hubei Province, Peoples R China.
C3 Wuhan University
RP Deng, K (通讯作者)，169 East Lake Rd, Wuhan 430071, Hubei Province, Peoples R China.
EM dk_1005@hotmail.com
FU Province Science Funds of Hubei, China [2012FFB04311]
FX This work was financed by Province Science Funds of Hubei, China
   (Project code: 2012FFB04311).
CR Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
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NR 19
TC 0
Z9 1
U1 0
U2 10
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD MAY-JUN
PY 2017
VL 51
IS 3
BP 318
EP 323
DI 10.4103/ortho.IJOrtho_220_16
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA EU4JM
UT WOS:000400995600011
PM 28566785
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Visser, R
   Milbrandt, K
   LumMin, S
   Wiseman, N
   Hancock, BJ
   Morris, M
   Keijzer, R
AF Visser, Robin
   Milbrandt, Kris
   LumMin, Suyin
   Wiseman, Nathan
   Hancock, Betty-Jean
   Morris, Melanie
   Keijzer, Richard
TI Applying vacuum to accomplish reduced wound infections in laparoscopic
   pediatric surgery
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 48th Annual Meeting of the Canadian-Association-of-Pediatric-Surgeons
   (CAPS)
CY SEP 22-24, 2016
CL Vancouver, CANADA
SP Canadian Assoc Pediat Surg
DE Vacuum dressing; Pediatric laparoscopic surgery; Surgical site infection
ID SURGICAL SITE INFECTIONS; ASSISTED CLOSURE; RISK-FACTORS; INCISION
   MANAGEMENT; APPENDECTOMY; CHILDREN; POPULATION; EXPERIENCE; OUTCOMES;
   THERAPY
AB Introduction: The prevention of surgical site infections has received little attention in pediatric surgery. Negative pressure wound therapy is used to treat complex wounds. We hypothesized that this principle could reduce wound infection rates following laparoscopic surgery. We tested this in a randomized controlled trial.
   Materials and methods: We randomized pediatric patients with an umbilical port site to a standard dressing or a vacuum dressing. The dressings were removed 48 h after surgery. A nurse blinded for the treatment inspected the umbilical wound between post-operative days 7-10 for infection. Data comparison was performed using a Fisher exact test with p < 0.05 defined as significant.
   Results: We recruited 90 patients over 2 years and randomized 44 to the vacuum dressing arm and 42 to the control arm. We observed a 2.8% (n = 1/35) infection rate in the vacuum dressing group and 3.3% (n = 1/30) in the control group (p = 1.0).
   Discussion: We ended our study early when an interim analysis showed an impractical number of patients would be required to achieve sufficient power. We did not find a significant difference between the control and vacuum dressings in reducing post-operative wound infections. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Visser, Robin] Univ Manitoba, Dept Gen Surg, Winnipeg, MB, Canada.
   [Milbrandt, Kris; LumMin, Suyin; Wiseman, Nathan; Hancock, Betty-Jean; Morris, Melanie; Keijzer, Richard] Univ Manitoba, Div Pediat Surg, Dept Surg, Winnipeg, MB, Canada.
   [Milbrandt, Kris; LumMin, Suyin; Wiseman, Nathan; Hancock, Betty-Jean; Morris, Melanie; Keijzer, Richard] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada.
   [Milbrandt, Kris; LumMin, Suyin; Wiseman, Nathan; Hancock, Betty-Jean; Morris, Melanie; Keijzer, Richard] Univ Manitoba, Childrens Hosp, Res Inst Manitoba, Winnipeg, MB, Canada.
C3 University of Manitoba; University of Manitoba; University of Manitoba;
   University of Manitoba; Children's Hospital Research Institute of
   Manitoba (CHRIM)
RP Keijzer, R (通讯作者)，Univ Manitoba, AE402-840 Sherbrook St, Winnipeg, MB R3A 1R9, Canada.
EM richardkeijzer@gmail.com
RI Keijzer, Richard/AAA-9598-2020
OI Keijzer, Richard/0000-0002-0108-3157
FU Children's Hospital Research Institute of Manitoba
FX We would like to thank all the personnel who helped make this trial a
   reality, including but not limited to the residents; operating theater,
   ward, and research nurses; attending surgeons; and our secretary Brandi.
   Thank you to the Children's Hospital Research Institute of Manitoba who
   provided grant funding.
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NR 42
TC 11
Z9 12
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD MAY
PY 2017
VL 52
IS 5
BP 849
EP 852
DI 10.1016/j.jpedsurg.2017.01.035
PG 4
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Surgery
GA EU5UC
UT WOS:000401098300037
PM 28245914
DA 2026-07-24
ER
PT J
AU Loftus, TJ
   Jordan, JR
   Croft, CA
   Smith, RS
   Efron, PA
   Moore, FA
   Mohr, AM
   Brakenridge, SC
AF Loftus, Tyler J.
   Jordan, Janeen R.
   Croft, Chasen A.
   Smith, R. Stephen
   Efron, Philip A.
   Moore, Frederick A.
   Mohr, Alicia M.
   Brakenridge, Scott C.
TI Emergent laparotomy and temporary abdominal closure for the cirrhotic
   patient
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 36th Annual Meeting of the Surgical-Infection-Society (SIS)
CY MAY 17-21, 2016
CL Palm Beach, FL
SP Surg Infect Soc
DE Temporary abdominal closure; Damage control surgery; Laparotomy; Open
   abdomen; Cirrhosis; Ascites
ID OPEN ABDOMEN; HEMODYNAMIC CONSEQUENCES; DAMAGE-CONTROL; MANAGEMENT;
   COAGULOPATHY; TRAUMA; FAILURE; BICARBONATE; PREDICTORS; MORBIDITY
AB Background: Temporary abdominal closure (TAC) may be performed for cirrhotic patients undergoing emergent laparotomy. The effects of cirrhosis on physiologic parameters, resuscitation requirements, and outcomes following TAC are unknown. We hypothesized that cirrhotic TAC patients would have different resuscitation requirements and worse outcomes than noncirrhotic patients.
   Methods: We performed a 3-year retrospective cohort analysis of 231 patients managed with TAC following emergent laparotomy for sepsis, trauma, or abdominal compartment syndrome. All patients were initially managed with negative pressure wound therapy (NPWT) TAC with intention for planned relaparotomy and sequential abdominal closure attempts at 24- to 48-h intervals.
   Results: At presentation, cirrhotic patients had higher incidence of acidosis (33% versus 17%) and coagulopathy (87% versus 54%) than noncirrhotic patients. Forty-eight hours after presentation, cirrhotic patients had a persistently higher incidence of coagulopathy (77% versus 44%) despite receiving more fresh frozen plasma (10.8 units versus 4.4 units). Cirrhotic patients had higher NPWT output (4427 mL versus 2375 mL) and developed higher vasopressor infusion rates (57% versus 29%). Cirrhotic patients had fewer intensive care unit-free days (2.3 versus 7.6 days) and higher rates of multiple organ failure (64% versus 34%), in-hospital mortality (67% versus 21%), and long-term mortality (80% versus 34%) than noncirrhotic patients.
   Conclusions: Cirrhotic patients managed with TAC are susceptible to early acidosis, persistent coagulopathy, large NPWT fluid losses, prolonged vasopressor requirements, multiple organ failure, and early mortality. Future research should seek to determine whether TAC provides an advantage over primary fascial closure for cirrhotic patients undergoing emergency laparotomy. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Loftus, Tyler J.; Jordan, Janeen R.; Croft, Chasen A.; Smith, R. Stephen; Efron, Philip A.; Moore, Frederick A.; Mohr, Alicia M.; Brakenridge, Scott C.] Univ Florida Hlth, Sepsis & Crit Illness Res Ctr, Dept Surg, 1600 SW Archer Rd,Room M-602, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Brakenridge, SC (通讯作者)，Univ Florida Hlth, Sepsis & Crit Illness Res Ctr, Dept Surg, 1600 SW Archer Rd,Room M-602, Gainesville, FL 32610 USA.
EM Scott.Brakenridge@surgery.ufl.edu
RI Mohr, Alicia/E-3016-2015; Loftus, Tyler/J-7761-2016; Brakenridge,
   Scott/AAD-6691-2019
OI Mohr, Alicia/0000-0003-1732-1313; Loftus, Tyler/0000-0001-5354-443X;
   Brakenridge, Scott/0000-0002-7327-3718; Smith,
   Robert/0000-0002-0455-6415
FU National Institute on Aging; National Institute of General Medical
   Sciences (NIGMS); postgraduate training grant in burns, trauma [T32
   GM-08721]; NIGMS;  [P30 AG028740];  [R01 GM105893-01A1];  [R01
   GM113945-01];  [P50 GM111152-01]; National Institute of General Medical
   Sciences [T32GM008721, R01GM105893] Funding Source: NIH RePORTER;
   National Institute on Aging [P30AG028740] Funding Source: NIH RePORTER
FX The authors acknowledge Cindy Scalamonti, CSTR for her assistance in
   maintaining, accessing, and assuring the quality of our institutional
   data registry. T.J.L. contributed to study design, data collection, data
   analysis, data interpretation, and manuscript composition. J.R.J.,
   C.A.C., R.S.S., and P.A.E. contributed to data interpretation and
   provided critical revisions. F.A.M., A.M.M., and S.C.B. contributed to
   study design, data interpretation, and provided critical revisions. The
   authors were supported in part by grants P30 AG028740 (S.C.B.) awarded
   by the National Institute on Aging and by R01 GM105893-01A1 (A.M.M.),
   R01 GM113945-01 (P.A.E.), and P50 GM111152-01 (S.C.B., F.A.M., A.M.M.,
   and P.A.E.) awarded by the National Institute of General Medical
   Sciences (NIGMS). T.J.L. was supported by a postgraduate training grant
   (T32 GM-08721) in burns, trauma, and perioperative injury by NIGMS.
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NR 43
TC 3
Z9 3
U1 0
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD APR
PY 2017
VL 210
BP 108
EP 114
DI 10.1016/j.jss.2016.11.013
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA EU6DU
UT WOS:000401125000013
PM 28457316
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Kääriäinen, M
   Kuuskeri, M
   Helminen, M
   Kuokkanen, H
AF Kaariainen, M.
   Kuuskeri, M.
   Helminen, M.
   Kuokkanen, H.
TI Greater Success of Primary Fascial Closure of the Open Abdomen: A
   Retrospective Study Analyzing Applied Surgical Techniques, Success of
   Fascial Closure, and Variables Affecting the Results
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Open abdomen; component separation; negative pressure wound therapy;
   mesh-mediated medial traction; fascial closure; abdominal catastrophe
ID ABDOMINAL-WALL RECONSTRUCTION; VACUUM; MANAGEMENT; TRACTION; TRAUMA
AB Background and Aims: The open abdomen technique is a standard procedure in the treatment of intra-abdominal catastrophe. Achieving primary abdominal closure within the initial hospitalization is a main objective. This study aimed to analyze the success of closure rate and the effect of negative pressure wound therapy, mesh-mediated medial traction, and component separation on the results. We present the treatment algorithm used in our institution in open abdomen situations based on these findings.
   Material and Methods: Open abdomen patients (n=61) treated in Tampere University Hospital from May 2005 until October 2013 were included in the study. Patient characteristics, treatment prior to closure, closure technique, and results were retrospectively collected and analyzed. The first group included patients in whom direct or bridged fascial closure was achieved, and the second group included those in whom only the skin was closed or a free skin graft was used. Background variables and variables related to surgery were compared between groups.
   Results and Conclusion: Most of the open abdomen patients (72.1%) underwent fascial defect repair during the primary hospitalization, and 70.5% of them underwent direct fascial closure. Negative pressure wound therapy was used as a temporary closure method for 86.9% of the patients. Negative pressure wound therapy combined with mesh-mediated medial traction resulted in the shortest open abdomen time (p=0.039) and the highest fascial repair rate (p=0.000) compared to negative pressure wound therapy only or no negative pressure wound therapy. The component separation technique was used for 11 patients; direct fascial closure was achieved in 5 and fascial repair by bridging the defect with mesh was achieved in 6. A total of 8 of 37 (21.6%) patients with mesh repair had a mesh infection. The negative pressure wound therapy combined with mesh-mediated medial traction promotes definitive fascial closure with a high closure rate and a shortened open abdomen time. The component separation technique can be used to facilitate fascial repair but it does not guarantee direct fascial closure in open abdomen patients.
C1 [Kaariainen, M.; Kuuskeri, M.] Tampere Univ Hosp, Dept Plast & Reconstruct Surg, POB 2000, Tampere 33521, Finland.
   [Helminen, M.] Univ Tampere, Sch Hlth Sci, Tampere, Finland.
   [Helminen, M.] Pirkanmaa Hosp Dist, Sci Ctr, Tampere, Finland.
   [Kuokkanen, H.] Helsinki Univ Hosp, Div Plast Surg, Helsinki, Finland.
C3 Tampere University; Tampere University Hospital; Tampere University;
   Pirkanmaa Hospital District; University of Helsinki; Helsinki University
   Central Hospital
RP Kääriäinen, M (通讯作者)，Tampere Univ Hosp, Dept Plast & Reconstruct Surg, POB 2000, Tampere 33521, Finland.
EM minna.t.kaariainen@gmail.com
RI Helminen, Mika/JBJ-2153-2023; /M-6470-2013
OI Helminen, Mika/0000-0001-5695-2084; 
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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   Rasilainen SK, 2012, BRIT J SURG, V99, P1725, DOI 10.1002/bjs.8914
   Rohrich RJ, 2000, PLAST RECONSTR SURG, V105, P202, DOI 10.1097/00006534-200001000-00036
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NR 18
TC 13
Z9 16
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD JUN
PY 2017
VL 106
IS 2
BP 145
EP 151
DI 10.1177/1457496916665542
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EV2BJ
UT WOS:000401558200007
PM 27528695
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Yu, PX
   Yu, NZ
   Yang, XN
   Jin, XL
   Lu, HB
   Qi, ZL
AF Yu, Panxi
   Yu, Nanze
   Yang, Xiaonan
   Jin, Xiaolei
   Lu, Haibin
   Qi, Zuoliang
TI Clinical Efficacy and Safety of Negative-Pressure Wound Therapy on
   Flaps: A Systematic Review
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Review
DE negative-pressure wound therapy; flap; efficacy
ID VACUUM-ASSISTED CLOSURE; IMPLANTABLE DOPPLER PROBE; MUSCLE FLAP; VENOUS
   CONGESTION; PEDICLE FLAP; RECONSTRUCTION; MANAGEMENT; DEVICE; HEAD;
   COMPLICATIONS
AB Background Although flap transfer is a popular reconstructive procedure with a high success rate, it is associated with a high complication rate and low salvage rate. During the past decade, negative-pressure wound therapy (NPWT) has been increasingly applied to facilitate flap transfer and salvage flaps threatened by complications. It has achieved some success, but its efficacy and safety remain controversial because of the limited number of reports and lack of systematic reviews.
   Methods English-language articles describing the application of NPWT on flaps were screened using predetermined inclusion and exclusion criteria. The articles were summarized and divided into groups based on the purpose of NPWT application. The complication rate, success rate, and salvage rate were obtained. Results Among the 3,395 articles searched, 16 articles describing 137 flaps were eligible. NPWT was applied on 105 (76.4%) newly transferred flaps to facilitate flap attachment and on 32 (23.4%) complication-threatened flaps to relieve flap infection and venous congestion. In total, complications developed in six flaps, three of which were lost; thus, the complication rate was 5.7% (6/105) and the success rate was 97.1% (102/105). Only 1 of the 32 threatened flaps was not successfully salvaged; thus, the salvage rate was 96.9% (31/32).
   Conclusion NPWT may facilitate flap transfer with few side effects and help to rescue flaps threatened by infection and venous congestion with a high salvage rate. Further studies are needed to test the safety of NPWT application on flaps with arterial compromise.
C1 [Yu, Panxi; Yang, Xiaonan; Jin, Xiaolei; Lu, Haibin; Qi, Zuoliang] Chinese Acad Med Sci, Peking Union Med Coll, Plast Surg Hosp, Dept 16, 33 Badachu Rd, Beijing 100144, Peoples R China.
   [Yu, Nanze] Chinese Acad Med Sci, Dept Plast Surg, Peking Union Med Coll Hosp, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Plastic Surgery Hospital - CAMS; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Peking Union
   Medical College Hospital
RP Qi, ZL (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll, Plast Surg Hosp, Dept 16, 33 Badachu Rd, Beijing 100144, Peoples R China.
EM qizuoliangls@163.com
RI ; Yang, Xiaonan/AAL-5154-2020
OI , Jin/0000-0001-9350-7916; 
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NR 51
TC 20
Z9 28
U1 0
U2 16
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD JUN
PY 2017
VL 33
IS 5
BP 358
EP 366
DI 10.1055/s-0037-1599076
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EV3TZ
UT WOS:000401683300008
PM 28235220
DA 2026-07-24
ER
PT J
AU Papadakis, M
   Rahmanian-Schwarz, A
   Bednarek, M
   Arafkas, M
   Holschneider, P
   Hübner, G
AF Papadakis, Marios
   Rahmanian-Schwarz, Afshin
   Bednarek, Marzena
   Arafkas, Mohamed
   Holschneider, Philipp
   Huebner, Gunnar
TI Negative-pressure wound therapy and early pedicle flap reconstruction of
   the chest wall after epirubicin extravasation
SO JOURNAL OF VASCULAR ACCESS
LA English
DT Article
ID CHEMOTHERAPY
AB Purpose: Accidental extravasation is a serious iatrogenic injury among patients receiving anthracycline-containing chemotherapy. The aim of this work is to present a combination therapy for chest wall reconstruction following epirubicin extravasation.
   Methods: Herein, we report a 68-year-old woman with massive soft tissue necrosis of the anterolateral chest wall after epirubicin extravasation from a port implanted in the subclavicular area.
   Results: The necrotic tissue was resected, the port was removed, and negative-pressure wound therapy was applied. Three weeks later, a latissimus dorsi pedicle flap was successfully used to cover the defect.
   Conclusions: To the best of the authors' knowledge, this is the first report of a strategy comprising the combination of negative-pressure wound therapy and a latissimus pedicle flap for reconstruction of the chest wall after soft tissue necrosis following epirubicin extravasation.
C1 [Papadakis, Marios; Rahmanian-Schwarz, Afshin; Bednarek, Marzena; Arafkas, Mohamed; Holschneider, Philipp; Huebner, Gunnar] Univ Hosp, Helios Clin Wuppertal, Dept Plast Surg, Witten, Germany.
RP Papadakis, M (通讯作者)，Helios Klinikum Wuppertal, Heusnerstr 40, D-42283 Wuppertal, Germany.
EM marios_papadakis@yahoo.gr
RI Papadakis, Marios/AAI-6622-2020
OI Papadakis, Marios/0000-0002-9020-874X
CR Aigner B, 2014, DERMATOLOGY, V229, P288, DOI 10.1159/000365391
   Azaïs H, 2015, J VASC ACCESS, V16, P31, DOI 10.5301/jva.5000316
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NR 10
TC 3
Z9 4
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1129-7298
EI 1724-6032
J9 J VASC ACCESS
JI J. Vasc. Access
PD MAY-JUN
PY 2017
VL 18
IS 3
BP E27
EP E29
DI 10.5301/jva.5000654
PG 3
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EV5JK
UT WOS:000401800700017
PM 28165571
DA 2026-07-24
ER
PT J
AU Tolonen, M
   Mentula, P
   Sallinen, V
   Rasilainen, S
   Bäcklund, M
   Leppäniemi, A
AF Tolonen, Matti
   Mentula, Panu
   Sallinen, Ville
   Rasilainen, Suvi
   Backlund, Minna
   Leppaniemi, Ari
TI Open abdomen with vacuum-assisted wound closure and mesh-mediated
   fascial traction in patients with complicated diffuse secondary
   peritonitis: A single-center 8-year experience
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT National Operative Days Conference
CY NOV 16, 2016
CL Helsinki, FINLAND
DE Intestinal fistula; intra-abdominal infections; negative-pressure wound
   therapy; second-look surgery
ID NEGATIVE-PRESSURE THERAPY; DAMAGE CONTROL SURGERY; ABDOMINAL
   COMPARTMENT; SEVERE SEPSIS; MANAGEMENT; PARADIGM; SCORE
AB BACKGROUND: Open abdomen (OA) treatment in patients with peritonitis is increasing worldwide. Various temporary abdominal closure devices are being used. This study included patients with complicated diffuse secondary peritonitis, OA, and vacuum-assisted wound closure and mesh-mediated fascial traction (VAWCM). The aim of this study was to describe mortality and major morbidity in terms of delayed primary fascial closure and enteroatmospheric fistula rates.
   METHODS: This was a single-academic-center retrospective study of consecutive patients with diffuse peritonitis, OA, and VAWCM between years 2008 and 2016. Descriptive and univariate analyses were performed.
   RESULTS: Forty-one patients were identified and analyzed. Median age was 59 years, preoperative septic shock was diagnosed in 54% (n = 22), and 59% (n = 24) had a postoperative peritonitis. Mortality was 29%(n = 12), and 76%(n = 31) of patients were admitted in the intensive care unit. The median duration of OA was 7 days with a median of two dressing changes. Delayed primary fascial closure rate among survivors was 92% (n = 33), and enteroatmospheric fistulas developed in 7% (n = 3). In a subgroup analysis, patients with OA in the primary laparotomy for peritonitis (n = 27) were compared with patients with OA in the subsequent laparotomies (n = 14). There were no significant differences between groups.
   CONCLUSIONS: The VAWCM technique in patients with complicated secondary diffuse peritonitis and OA yields excellent results in terms of delayed primary fascial closure rate and a low number of enteroatmospheric fistulas. It seems to be safe to close the abdomen at the index laparotomy, if possible, even if there is a risk of a need of OA later. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Tolonen, Matti; Mentula, Panu; Sallinen, Ville; Rasilainen, Suvi; Leppaniemi, Ari] Helsinki Univ Hosp, Dept Abdominal Surg, Abdominal Ctr, Haartmaninkatu 4, Helsinki 00290, Finland.
   [Tolonen, Matti; Mentula, Panu; Sallinen, Ville; Rasilainen, Suvi; Backlund, Minna; Leppaniemi, Ari] Univ Helsinki, Helsinki, Finland.
   [Sallinen, Ville] Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Abdominal Ctr, Helsinki, Finland.
   [Backlund, Minna] Helsinki Univ Hosp, Dept Anesthesiol Intens Care & Pain Med, Div Intens Care Med, Helsinki, Finland.
C3 University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; University of Helsinki; Helsinki University Central
   Hospital; University of Helsinki; Helsinki University Central Hospital
RP Tolonen, M (通讯作者)，Helsinki Univ Hosp, Dept Abdominal Surg, Abdominal Ctr, Haartmaninkatu 4, Helsinki 00290, Finland.
EM matti.tolonen@hus.fi
RI Mentula, Panu/H-9025-2019; Leppäniemi, Ari/GQZ-7991-2022; Sallinen,
   Ville/AAG-2285-2021; Tolonen, Matti/I-9970-2019
OI Mentula, Panu/0000-0002-6516-3797; 
FU Helsinki University Central Hospital; Mary and Georg Ehrnrooth's
   Foundation; Martti I. Turunen Foundation; Vatsatautien Tutkimussaatio
   Foundation
FX This study was financially supported by Helsinki University Central
   Hospital Research Funds (Government Research Funds), Mary and Georg
   Ehrnrooth's Foundation, Martti I. Turunen Foundation, and Vatsatautien
   Tutkimussaatio Foundation.
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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NR 40
TC 35
Z9 48
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD JUN
PY 2017
VL 82
IS 6
BP 1100
EP 1105
DI 10.1097/TA.0000000000001452
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Surgery
GA EV5MV
UT WOS:000401811900022
PM 28338592
DA 2026-07-24
ER
PT J
AU Krebs, B
   Jagric, T
AF Krebs, Bojan
   Jagric, Tomaz
TI Does Negative-Pressure Wound Therapy for the Open Abdomen Benefit the
   Patient? A Retrospective Cohort Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE general surgery; mortality; negative-pressure wound therapy; open
   abdomen
ID DAMAGE CONTROL; MANAGEMENT; PATHOPHYSIOLOGY
AB OBJECTIVE: Negative-pressure wound therapy (NPWT) is the most modern and sophisticated method of temporary abdominal closure. The aim of the study was to determine the significant predictors for mortality in patients with NPWT.
   SETTING: University Clinical Centre Maribor, Slovenia
   MATERIALS AND METHODS: The authors performed a retrospective cohort study of all patients treated with NPWT between January 1, 2011, and December 31, 2014.
   RESULTS: In the univariate analysis, the type of wound closure, more than 7 NPWT changes, the total days with NPWT, and time to wound closure were significantly associated with death of the patient. In the multivariate analysis, only the number of more than 7 NPWT changes was found as a significant predictor for death (P = .038).
   CONCLUSIONS: Negative-pressure wound therapy is a method of choice for the treatment of open abdomen if there is a clear indication. However, clinicians should try all measures to remove the NPWT system and close the abdomen as soon as possible because prolonged use is associated with significantly higher mortality.
C1 [Krebs, Bojan; Jagric, Tomaz] Univ Clin Ctr Maribor, Dept Abdominal Surg, Maribor, Slovenia.
C3 University of Maribor
RP Krebs, B (通讯作者)，Univ Clin Ctr Maribor, Dept Abdominal Surg, Maribor, Slovenia.
CR Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
   Björck M, 2009, WORLD J SURG, V33, P1154, DOI 10.1007/s00268-009-9996-3
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   Gentile LF, 2012, J TRAUMA ACUTE CARE, V72, P1491, DOI 10.1097/TA.0b013e318256e000
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   Kaplan M, 2005, WOUNDS, P1
   Keel M, 2005, INJURY, V36, P691, DOI 10.1016/j.injury.2004.12.037
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   Parlato M, 2015, METHODS MOL BIOL, V1237, P149, DOI 10.1007/978-1-4939-1776-1_15
   Quyn AJ, 2012, COLORECTAL DIS, V14, pE429, DOI 10.1111/j.1463-1318.2012.03045.x
   Richter S, 2013, GASTROENT RES PRACT, V2013, DOI 10.1155/2013/730829
   Roberts DJ, 2012, J TRAUMA ACUTE CARE, V73, P629, DOI 10.1097/TA.0b013e31825c130e
   Shapiro MB, 2000, J TRAUMA, V49, P969, DOI 10.1097/00005373-200011000-00033
   Vargo D, 2009, AM SURGEON, V75, pS1
   von Elm E, 2007, LANCET, V370, P1453, DOI 10.1002/ana.22307
   Ward NS, 2008, CLIN CHEST MED, V29, P617, DOI 10.1016/j.ccm.2008.06.010
NR 23
TC 0
Z9 2
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUN
PY 2017
VL 30
IS 6
BP 256
EP 260
DI 10.1097/01.ASW.0000516196.19330.6f
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA EV5SA
UT WOS:000401826300003
PM 28520603
DA 2026-07-24
ER
PT J
AU Lozano-Balderas, G
   Ruiz-Velasco-Santacruz, A
   Díaz-Elizondo, JA
   Gómez-Navarro, JA
   Flores-Villalba, E
AF Lozano-Balderas, Gerardo
   Ruiz-Velasco-Santacruz, Alejandro
   Antonio Diaz-Elizondo, Jose
   Antonio Gomez-Navarro, Juan
   Flores-Villalba, Eduardo
TI Surgical Site Infection Rate Drops to 0% Using a Vacuum-Assisted Closure
   in Contaminated/Dirty Infected Laparotomy Wounds
SO AMERICAN SURGEON
LA English
DT Article
ID NEGATIVE-PRESSURE THERAPY; PRIMARY SKIN CLOSURE; OPEN ABDOMEN;
   INCISIONS; HERNIA
AB Wound site infections increase costs, hospital stay, morbidity, and mortality. Techniques used for wounds management after laparotomy are primary, delayed primary, and vacuum-assisted closures. The objective of this study is to compare infection rates between those techniques in contaminated and dirty/ infected wounds. Eighty-one laparotomized patients with Class III or IV surgical wounds were enrolled in a three-arm randomized prospective study. Patients were allocated to each group with the software Research Randomizer (R) (Urbaniak, G. C.,& Plous, S., Version 4.0). Presence of infectionwas determined by a certified board physician according to Centers forDisease Control's Criteria for Defining a Surgical Site Infection. Twenty-seven patients received primary closure, 29 delayed primary closure, and 25 vacuum-assisted closure, with no exclusions for analysis. Surgical site infection was present in 10 (37%) patients treated with primary closure, 5 (17%) with primary delayed closure, and 0 (0%) patients receiving vacuum-assisted closure. Statistical significance was found between infection rates of the vacuum-assisted group and the other two groups. No significant difference was found between the primary and primary delayed closure groups. The infection rate in contaminated/dirty-infected laparotomy wounds decreases from37 and 17 per cent with a primary and delayed primary closures, respectively, to 0 per cent with vacuum-assisted systems.
C1 [Lozano-Balderas, Gerardo; Ruiz-Velasco-Santacruz, Alejandro; Antonio Diaz-Elizondo, Jose; Antonio Gomez-Navarro, Juan; Flores-Villalba, Eduardo] Tecnol Monterrey, Escuela Med, Batallon San Patricio 112 Piso 1 Ote Col Real San, San Pedro Garza Garcia 66278, NL, Mexico.
C3 Tecnologico de Monterrey
RP Flores-Villalba, E (通讯作者)，Tecnol Monterrey, Escuela Med, Batallon San Patricio 112 Piso 1 Ote Col Real San, San Pedro Garza Garcia 66278, NL, Mexico.
EM eduardofloresvillalba@itesm.mx
RI Flores-Villalba, Eduardo/U-2936-2018; Diaz Elizondo, Jose
   Antonio/ABW-9848-2022
OI Flores-Villalba, Eduardo/0000-0002-6048-5957; Lozano-Balderas,
   Gerardo/0000-0002-9074-8973; Diaz Elizondo, Jose
   Antonio/0000-0002-7441-034X; Ruiz-Velasco-Santacruz,
   Alejano/0000-0002-2398-2268
CR Anthony T, 2000, WORLD J SURG, V24, P95, DOI 10.1007/s002689910018
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NR 18
TC 31
Z9 34
U1 0
U2 6
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD MAY
PY 2017
VL 83
IS 5
BP 512
EP 514
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EV7RC
UT WOS:000401976800028
PM 28541864
DA 2026-07-24
ER
PT J
AU Lee, AJ
   Sheppard, CE
   Kent, WDT
   Mewhort, H
   Sikdar, KC
   Fedak, PWM
AF Lee, Arthur J.
   Sheppard, Christina E.
   Kent, William D. T.
   Mewhort, Holly
   Sikdar, Khokan C.
   Fedak, Paul W. M.
TI Safety and efficacy of prophylactic negative pressure wound therapy
   following open saphenous vein harvest in cardiac surgery: a feasibility
   study
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Wound healing; Cardiac surgery
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; INFECTIONS; INCISIONS
AB OBJECTIVES: Surgical site complications following great saphenous vein (GSV) harvest presents a significant risk of morbidity. Negative pressure wound therapy (NPWT) has shown promise in the treatment and prophylaxis of open wounds and surgical incisions but has not been studied following GSV harvest. We performed a feasibility study examining the use of NPWT following GSV harvest for coronary bypass surgery.
   METHODS: Sixty-four patients were recruited in this single-centre, single-blind, randomized controlled trial. The primary endpoint assessed feasibility by examining rates of device complication and malfunction. Secondary endpoints included rates of surgical site infection, lower leg complications, discharge date, and quality of life at discharge and 6 weeks. NPWT was delivered using the Prevena NPWT device.
   RESULTS: There were no complications associated with NPWT which required intervention aside from discontinuation. NPWT was tolerated in 91% (30/33) of patients for the duration of treatment with an average of 4.8 days (+/- 1.45 days). Device malfunction which required discontinuation was 6% (2/33) and involved a malfunctioning pressure sensor and did not affect patient care or present safety concerns. One patient had allergic contact dermatitis to the adhesive and had the device removed. NPWT patients had an earlier date of discharge (6 vs 10 days, P = 0.008), increased ability for self-care (P = 0.0234) and quality of life (P = 0.039) at initial assessment, and increased mobility at initial and follow-up assessment (P = 0.0117 and 0.0123).
   CONCLUSIONS: The use of NPWT following GSV harvest is safe, well tolerated and improves postoperative recovery with prolonged impact on mobility at 6 weeks.
C1 [Lee, Arthur J.] Univ British Columbia, Div Cardiac Surg, Dept Surg, Vancouver, BC, Canada.
   [Sheppard, Christina E.; Kent, William D. T.; Mewhort, Holly; Sikdar, Khokan C.; Fedak, Paul W. M.] Univ Calgary, Libin Cardiovasc Inst Alberta, Dept Cardiac Sci, Calgary, AB, Canada.
C3 University of British Columbia; University of Calgary; Libin
   Cardiovascular Institute Of Alberta
RP Fedak, PWM (通讯作者)，Dept Cardiac Sci, Div Cardiac Surg, C880,1403-29 St NW, Calgary, AB T2N 2T9, Canada.
EM paul.fedak@gmail.com
RI ; Kent, William/AAA-3834-2020
OI Mewhort, Holly/0000-0002-3503-6076; Fedak, Paul/0000-0003-0658-9381
FU KCI USA Incorporated, an Acelity Company
FX This work was supported by KCI USA Incorporated, an Acelity Company.
CR [Anonymous], 2004, Zhongguo Linchuang Kangfu
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NR 23
TC 29
Z9 29
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD MAR
PY 2017
VL 24
IS 3
BP 324
EP 328
DI 10.1093/icvts/ivw400
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA EV9KV
UT WOS:000402105800002
PM 28025309
OA Bronze
DA 2026-07-24
ER
PT J
AU Nolff, MC
   Fehr, M
   Reese, S
   Meyer-Lindenberg, AE
AF Nolff, Mirja Christine
   Fehr, Michael
   Reese, Sven
   Meyer-Lindenberg, Andrea E.
TI Retrospective comparison of negative pressure wound therapy and
   silver-coated foam dressings in open-wound treatment in cats
SO JOURNAL OF FELINE MEDICINE AND SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; SEPTIC PERITONITIS;
   BLOOD-FLOW; DOGS; MANAGEMENT; SKIN; PROLIFERATION; VIABILITY; BACTERIA
AB Objectives The objective of this study was to evaluate negative pressure wound therapy (NPWT) for the treatment of complicated wounds in cats.
   Methods Twenty cats undergoing open-wound treatment in two clinics were classed according to treatment method: NPWT (group A, n = 10) and polyurethane foam dressing (group B, n = 10). Pairs of patients from each group were matched based on wound conformation, localisation and underlying cause. Cats from both groups were compared in terms of duration of previous treatment, time to closure and complications.
   Results Signalment, duration of previous treatment, antibiotic and antiseptic treatment, and bacterial status were comparable between groups. Total time to wound closure was significantly shorter (P = 0.046, strong effect size; Cohen d = 0.8) in group A (25.8 days, range 11.0-57.0 days) compared with group B (39.5 days, range 28.0-75.0 days). NPWT-treated wounds suffered fewer complications and became septic less frequently during treatment compared with wounds treated with a foam dressing. The progression of fat tissue necrosis was particularly well controlled under NPWT, resulting in fewer deaths due to this condition in this group. However, although a strong effect of NPWT on the progression of infection, fever and sepsis was detected (Cramer-V 0.5), this difference was not significant.
   Conclusions and relevance This study demonstrated that time to healing was considerably shorter, and complication rate lower, in NPWT-treated animals compared with foam dressing-treated cats. In particular, the effective management of infection by NPWT emphasises the value of NPWT in the treatment of cats suffering from infected wounds.
C1 [Nolff, Mirja Christine; Meyer-Lindenberg, Andrea E.] Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Vet Str 13, Munich, Germany.
   [Fehr, Michael] Univ Vet Med Hannover, Small Anim Clin, Hannover, Germany.
   [Reese, Sven] Ludwig Maximilians Univ Munchen, Dept Vet Basic Sci, Munich, Germany.
C3 University of Munich; University of Veterinary Medicine Hannover;
   University of Munich
RP Nolff, MC (通讯作者)，Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Vet Str 13, Munich, Germany.
EM m.nolff@lmu.de
RI Reese, Sven/F-1826-2016; Nolff, Mirja/W-6756-2019; Meyer-Lindenberg,
   Andrea/H-1076-2011
OI Reese, Sven/0000-0002-4605-9791; Nolff, Mirja/0000-0001-9317-7769;
   Meyer-Lindenberg, Andrea/0000-0001-6137-3773
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NR 43
TC 8
Z9 11
U1 3
U2 22
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1098-612X
EI 1532-2750
J9 J FELINE MED SURG
JI J. Feline Med. Surg.
PD JUN
PY 2017
VL 19
IS 6
BP 624
EP 630
DI 10.1177/1098612X16645141
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA EV9VX
UT WOS:000402135500009
PM 27102692
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Chetter, IC
   Oswald, AV
   Fletcher, M
   Dumville, JC
   Cullum, NA
AF Chetter, I. C.
   Oswald, A. V.
   Fletcher, M.
   Dumville, J. C.
   Cullum, N. A.
TI A survey of patients with surgical wounds healing by secondary
   intention; an assessment of prevalence, aetiology, duration and
   management
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Surgical wounds; Secondary intention
ID PILONIDAL-SINUS; RISK
AB Background: Surgical wounds healing by secondary intention (SWHSI) are often difficult and costly to treat. There is a dearth of clinical and research information regarding SWHSI. The aim of this survey was to estimate the prevalence of SWHSI and to characterise the aetiology, duration and management of these wounds.
   Methods: Anonymised data were collected from patients with SWHSI receiving treatment in primary, secondary and community settings. Over a two weeks period, data were collected on the patients, their SWHSI, clinical and treatment details.
   Results: Data were collected from 187 patients with a median age of 58.0 (95% CI = 55 to 61) years. The prevalence of SWHSI was 0.41 (95% CI = 0.35 to 0.47) per 1000 population. More patients with SWHSI were being treated in community (109/187, 58.3%) than in secondary (56/187, 29.9%) care settings. Most patients (164/187, 87.7%) had one SWHSI and the median duration of wounds was 28.0 (95% CI = 21 to 35) days. The most common surgical specialities associated with SWHSI were colorectal (80/187, 42.8%), plastics (24/187, 12.8%) and vascular (22/187, 11.8%) surgery. Nearly half of SWHSI were planned to heal by secondary intention (90/187, 48.1%) and 77/187 (41.2%) were wounds that had dehisced. Dressings were the most common single treatment for SWHSI, received by 169/181 (93.4%) patients. Eleven (6.1%) patients were receiving negative pressure wound therapy.
   Conclusions: This survey provides a previously unknown insight into the occurrence, duration, treatment and types of surgery that lead to SWHSI. This information will be of value to patients, health care providers and researchers. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of Tissue Viability Society.
C1 [Chetter, I. C.; Oswald, A. V.] Hull & East Yorkshire NHS Trust, Hull York Med Sch, Acad Vasc Surg Unit, Kingston Upon Hull, N Humberside, England.
   [Fletcher, M.] Marfleet Primary Hlth Care Ctr, City Hlth Care Partnership CIC, Kingston Upon Hull, N Humberside, England.
   [Dumville, J. C.; Cullum, N. A.] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester, Lancs, England.
C3 University of York - UK; University of Hull; University of Manchester
RP Chetter, IC (通讯作者)，Hull & East Yorkshire NHS Trust, Acad Vasc Surg Unit, Anlaby Rd, Kingston Upon Hull HU3 2JZ, N Humberside, England.
EM ian.chetter@hey.nhs.uk
RI Cullum, Nicky/F-2438-2011; Dumville, Jo/O-7867-2014
OI Cullum, Nicky/0000-0003-2631-123X; Dumville, Jo/0000-0002-6546-3685;
   chetter, ian/0000-0002-2566-6859
FU National Institute for Health Research (NIHR) under its Programme Grants
   for Applied Research Programme [RP-PG 0609-10171]; National Institute
   for Health Research [RP-PG-0609-10171, NF-SI-0512-10028] Funding Source:
   researchfish; National Institutes of Health Research (NIHR)
   [RP-PG-0609-10171] Funding Source: National Institutes of Health
   Research (NIHR)
FX This paper presents independent research funded by the National
   Institute for Health Research (NIHR) under its Programme Grants for
   Applied Research Programme (Grant Reference Number RP-PG 0609-10171).
   The views expressed in this paper are those of the authors and not
   necessarily those of the NHS, the NIHR or the Department of Health.
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NR 24
TC 31
Z9 34
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-206X
J9 J TISSUE VIABILITY
JI J. Viab.
PD MAY
PY 2017
VL 26
IS 2
BP 103
EP 107
DI 10.1016/j.jtv.2016.12.004
PG 5
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA EW0YA
UT WOS:000402215900004
PM 28049612
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Helito, CP
   Bueno, DK
   Giglio, PN
   Bonadio, MB
   Pécora, JR
   Demange, MK
AF Helito, Camilo Partezani
   Bueno, Daniel Kamura
   Giglio, Pedro Nogueira
   Bonadio, Marcelo Batista
   Pecora, Jose Ricardo
   Demange, Marco Kawamura
TI NEGATIVE-PRESSURE WOUND THERAPY IN THE TREATMENT OF COMPLEX INJURIES
   AFTER TOTAL KNEE ARTHROPLASTY
SO ACTA ORTOPEDICA BRASILEIRA
LA English
DT Article
DE Negative-pressure wound therapy; Arthroplasty, replacement knee;
   Surgical wound dehiscence; Infection
ID VACUUM-ASSISTED CLOSURE; TOTAL HIP; SURGICAL INCISION; ECONOMIC-IMPACT;
   INFECTION; DRAINAGE; SURGERY; COMPLICATIONS; MANAGEMENT; DRESSINGS
AB Objective: To present an experience with negative-pressure wound therapy (NPWT) in the treatment of surgical wounds in patients treated for infections after total knee arthroplasty (TKA) with or without dehiscence and prophylaxis in wounds considered at risk of healing problems. Methods: We prospectively evaluated patients with TKA infection with or without surgical wound dehiscence and patients with risk factors for infection or surgical wound complications treated with Pico (R) device for NPWT in addition to standard treatment of infection or dehiscence in our institution. We considered as an initial favorable outcome the resolution of the infectious process and the closure of the surgical wound dehiscences in the treated cases and the good progression of the wound without complicating events in the prophylactic cases. Results: We evaluated 10 patients who used Pico (R) in our service. All patients had a favorable outcome according to established criteria. No complications were identified regarding the use of the NPWT device. The mean follow-up of the patients after the use of the device was 10.5 months. Conclusion: The NPWT can be safely used in wound infections and complications following TKA with promising results. Long-term randomized prospective studies should be conducted to prove its effectiveness.
C1 [Helito, Camilo Partezani; Bueno, Daniel Kamura; Giglio, Pedro Nogueira; Bonadio, Marcelo Batista; Pecora, Jose Ricardo; Demange, Marco Kawamura] Univ Sao Paulo, Hosp Clin, Fac Med, Inst Ortopedia & Traumatol,Knee Surg Div, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Helito, CP (通讯作者)，Rua Dr Ovidio Pires Campos 333, BR-05403010 Sao Paulo, SP, Brazil.
EM camilo_helito@yahoo.com.br
RI Partezani Helito, Camilo/X-3880-2019; Giglio, Peo/A-7488-2017; Demange,
   Marco/D-2975-2009; Pécora, José Ricardo/HGD-1086-2022
OI Partezani Helito, Camilo/0000-0003-1139-2524; Giglio,
   Peo/0000-0002-5855-0975; Demange, Marco/0000-0003-1999-9478; Pécora,
   José Ricardo/0000-0003-1621-5252
CR Ahmad Z, 2013, INT J LOW EXTR WOUND, V12, P16, DOI 10.1177/1534734612474305
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NR 29
TC 6
Z9 10
U1 0
U2 8
PU ATHA COMUNICACAO & EDITORA
PI SAO PAULO
PA RUA MACHADO BITTENCOURT, 190-40 ANDAR, CONJ 410, SAO PAULO, Sao Paulo,
   BRAZIL
SN 1413-7852
EI 1809-4406
J9 ACTA ORTOP BRAS
JI Acta Ortop. Bras.
PD MAR-APR
PY 2017
VL 25
IS 2
BP 85
EP 88
DI 10.1590/1413-785220172502169053
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA EW4IB
UT WOS:000402464100005
PM 28642657
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Wang, ZT
   Cao, JL
   Yuan, P
   Wang, LM
   He, ZH
   Lv, W
   Hu, J
AF Wang, Zhi-Tian
   Cao, Jin-Lin
   Yuan, Ping
   Wang, Lu-Ming
   He, Zhe-Hao
   Lv, Wang
   Hu, Jian
TI A novel facilitated negative-pressure wound therapy for thoracic
   incision infection after esophagectomy
SO JOURNAL OF THORACIC DISEASE
LA English
DT Article
DE Negative-pressure wound therapy (NPWT); novel facilitated device;
   thoracic incision infection; esophagectomy
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTIONS; MANAGEMENT
AB Background: Negative-pressure wound therapy (NPWT) is the therapeutic management of traumatic soft-tissue wounds and infections. The efficacy of NPWT in the treatment of thoracic incision infection is unclear. We assess the effectiveness and safety of a novel facilitated NPWT for thoracic incision infection after esophagectomy.
   Methods: Between Jan. 2013 and Mar. 2016, 380 patients underwent open esophagectomy in our department. Forty-five patients with thoracic incision infection were retrospectively reviewed. Of these patients, 25 were treated with NPWT and 20 patients were treated with open wound dressing. The patients' clinical demographic data, postoperative outcomes and wound treatment cost are reviewed.
   Results: The thoracic incision infection rate was 11.8%. All of the incision infections were cured in the hospital or on an outpatient basis. No allergic reactions or other side effects occurred with NPWT. Although the patients who were treated with NPWT did not have a significantly shorter postoperative hospital stay than those treated with open wound dressing (P=0.092), the use of NPWT therapy for thoracic incision infection led to a shorter wound healing times (13 vs. 20 days; P=0.004) and a lower wound treatment cost (P=0.020).
   Conclusions: Thoracic incision infection is a common complication of esophagectomy. NPWT is a safe and effective therapeutic management for thoracic incision infection that is associated with shortened wound healing times and reduced wound treatment costs than traditional open wound treatment.
C1 [Wang, Zhi-Tian; Cao, Jin-Lin; Yuan, Ping; Wang, Lu-Ming; He, Zhe-Hao; Lv, Wang; Hu, Jian] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Thorac Surg, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Hu, J (通讯作者)，Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Thorac Surg, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM hujian_med2@163.com
CR Alexander JW, 2011, ANN SURG, V253, P1082, DOI 10.1097/SLA.0b013e31821175f8
   [Anonymous], ANN SURG
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NR 22
TC 1
Z9 4
U1 0
U2 3
PU PIONEER BIOSCIENCE PUBL CO
PI HONG KONG
PA 9A GOLD SHINE TOWER, 346-348 QUEEN'S RD CENTRAL, SHEUNG WAN, HONG KONG,
   00000, PEOPLES R CHINA
SN 2072-1439
EI 2077-6624
J9 J THORAC DIS
JI J. Thorac. Dis.
PD APR
PY 2017
VL 9
IS 4
SI SI
BP 1113
EP 1118
DI 10.21037/jtd.2017.03.160
PG 6
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA EW4NS
UT WOS:000402478800056
PM 28523167
OA gold
DA 2026-07-24
ER
PT J
AU Shen, P
   Blackham, AU
   Lewis, S
   Clark, CJ
   Howerton, R
   Mogal, HD
   Dodson, RM
   Russell, GB
   Levine, EA
AF Shen, Perry
   Blackham, Aaron U.
   Lewis, Stacey
   Clark, Clancy J.
   Howerton, Russell
   Mogal, Harveshp D.
   Dodson, Rebecca M.
   Russell, Gregory B.
   Levine, Edward A.
TI Phase II Randomized Trial of Negative-Pressure Wound Therapy to Decrease
   Surgical Site Infection in Patients Undergoing Laparotomy for
   Gastrointestinal, Pancreatic, and Peritoneal Surface Malignancies
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article; Proceedings Paper
CT 128th Annual Meeting of the Southern-Surgical-Association
CY DEC, 2016
CL Palm Beach, FL
SP So Surg Assoc
ID VACUUM-ASSISTED CLOSURE; OPEN COLORECTAL SURGERY; LAPAROSCOPIC SURGERY;
   META-ANALYSIS; MORTALITY; RISK; COMPLICATIONS; EXPERIENCE; INCISIONS;
   HOSPITALIZATION
AB BACKGROUND: Surgical site infections (SSIs) remain a major source of morbidity and cost after resection of intra-abdominal malignancies. Negative-pressure wound therapy (NPWT) has been reported to significantly reduce SSIs when applied to the closed laparotomy incision. This article reports the results of a randomized clinical trial examining the effect of NPWT on SSI rates in surgical oncology patients with increased risk for infectious complications.
   STUDY DESIGN: From 2012 to 2016, two hundred and sixty-five patients who underwent open resection of intra-abdominal neoplasms were stratified into 3 groups: gastrointestinal (n = 57), pancreas (n = 73), or peritoneal surface (n = 135) malignancy. They were randomized to receive NPWT or standard surgical dressing (SSD) applied to the incision from postoperative days 1 through 4. Primary outcomes of combined incisional (superficial and deep) SSI rates were assessed up to 30 days after surgery.
   RESULTS: There were no significant differences in superficial SSIs (12.8% vs 12.9%; p > 0.99) or deep SSI (3.0% vs 3.0%; p > 0.99) rates between the SSD and NPWT groups, respectively. When stratified by type of surgery, there were still no differences in combined incisional SSI rates for gastrointestinal (25% vs 24%; p > 0.99), pancreas (22% vs 22%; p > 0.99), and peritoneal surface malignancy (9% vs 9%; p > 0.99) patients. When performing univariate and multi-variate logistic regression analysis of demographic and operative factors for the development of combined incisional SSI, the only independent predictors were preoperative albumin (p = 0.0031) and type of operation (p = 0.018).
   CONCLUSIONS: Use of NPWT did not significantly reduce incisional SSI rates in patients having open resection of gastrointestinal, pancreatic, or peritoneal surface malignancies. Based on these results, at this time NPWT cannot be recommended as a therapeutic intervention to decrease infectious complications in these patient populations. (C) 2017 by the American College of Surgeons. Published by Elsevier Inc. All rights reserved.)
C1 [Shen, Perry; Blackham, Aaron U.; Clark, Clancy J.; Howerton, Russell; Mogal, Harveshp D.; Dodson, Rebecca M.; Levine, Edward A.] Wake Forest Sch Med, Dept Gen Surg, Sect Surg Oncol, Watlington Hall,5th Floor, Winston Salem, NC 27157 USA.
   [Russell, Gregory B.] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA.
   [Lewis, Stacey] Wake Forest Baptist Med Ctr, Wake Forest Baptist Comprehens Canc Ctr, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest University; Wake Forest University;
   Wake Forest Baptist Medical Center
RP Shen, P (通讯作者)，Wake Forest Sch Med, Dept Gen Surg, Sect Surg Oncol, Watlington Hall,5th Floor, Winston Salem, NC 27157 USA.
EM pshen@wakehealth.edu
RI Mogal, Harveshp/HLH-2501-2023
OI Mogal, Harveshp/0000-0001-5743-1424
FU Wake Forest Department of General Surgery; Wake Forest University
   Biostatistics shared resource (NCI) [CCSG P30CA012197]; National Cancer
   Institute [P30CA012197] Funding Source: NIH RePORTER
FX This work was supported by the Wake Forest Department of General Surgery
   and the Wake Forest University Biostatistics shared resource (NCI CCSG
   P30CA012197).
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NR 46
TC 100
Z9 105
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD APR
PY 2017
VL 224
IS 4
BP 726
EP 737
DI 10.1016/j.jamcollsurg.2016.12.028
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA EW4SR
UT WOS:000402491700066
PM 28088597
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Aydin, S
   Temur, B
   Suzan, D
   Kirat, B
   Demir, IH
   Özen, M
   Erek, E
AF Aydin, Selim
   Temur, Bahar
   Suzan, Dilek
   Kirat, Baris
   Demir, Ibrahim Halil
   Ozen, Metehan
   Erek, Ersin
TI Mediastinal vacuum-assisted closure therapy following pediatric
   congenital cardiac surgery
SO TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND
   CARDIOVASCULAR SURGERY
LA Turkish
DT Article
DE Congenital heart surgery; mediastinitis; newborn; sternum;
   vacuum-assisted closure
ID WOUND CONTROL; INFECTIONS; EXPERIENCE; CHILDREN; PATIENT
AB Background: In this study, we report nine pediatric cases who developed sternal wound complications following complex congenital cardiac surgery and treated with mediastinal vacuum-assisted closure technique.
   Methods: Between January 2014 and December 2015, a total of 473 congenital heart operations were performed in our hospital. Of these patients, nine (8 males, 1 females; median age 24 days; range 15 days to 14 months) underwent mediastinal vacuum-assisted closure therapy. The indication of vacuum-assisted closure therapy was mediastinitis in five patients and sternal wound complications in four patients.
   Results: Sternum was left open in four patients after the initial operation. The median time from opening sternum to vacuum-assisted closure therapy was 10 days (range, 7 to 15 days) in these patients. Indications were positive mediastinal cultures in three patients and intolerance for sternal closure due to ventricular dysfunction and cardiac edema in one patient. In the remaining five patients, sternal wound complications developed later and vacuum-assisted closure therapy was applied after a median of 19 days (range, 11 to 36 days) after the operation. Mediastinal cultures were positive in two patients. Two patients (22%) died of sepsis and multi-organ failure. In the remaining patients, sternal wounds were closed within seven days (range, 5 to 19 days), when sternal cultures were negative or good granulation was obtained. Recurrent sternal wound complication developed in one patient (14.2%) and vacuum-assisted closure therapy was repeated. All patients, except two, underwent vacuum-assisted closure therapy in the intensive care unit.
   Conclusion: Mediastinal vacuum-assisted closure therapy is a good option in children with sternal wound complications after cardiac surgery. In addition, it may accelerate the healing process and reduce medical resource use.
C1 [Aydin, Selim; Temur, Bahar; Suzan, Dilek; Erek, Ersin] Acibadem Univ, Atakent Hastanesi, Kalp & Damar Cerrahisi Bolumu, TR-34303 Istanbul, Turkey.
   [Kirat, Baris] Acibadem Univ, Atakent Hastanesi, Anesteziyoloji & Reanimasyon Bolumu, Istanbul, Turkey.
   [Demir, Ibrahim Halil] Acibadem Univ, Atakent Hastanesi, Cocuk Kardiyolojisi Bolumu, Istanbul, Turkey.
   [Ozen, Metehan] Acibadem Univ, Atakent Hastanesi, Cocuk Enfeksiyon Hastaliklari Bolumu, Istanbul, Turkey.
C3 Acibadem University; Acibadem University; Acibadem University; Acibadem
   University
RP Aydin, S (通讯作者)，Acibadem Univ, Atakent Hastanesi, Kalp & Damar Cerrahisi Bolumu, TR-34303 Istanbul, Turkey.
EM draydinselim@yahoo.com
RI demir, ibrahim halil/HKV-0784-2023; Aydin, Selim/MZQ-4617-2025; Ozen,
   Metehan/X-2705-2018; /W-8135-2018
OI demir, ibrahim halil/0000-0002-9079-9818; Aydin,
   Selim/0000-0003-2708-2125; Ozen, Metehan/0000-0003-4088-3103; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Erek E, 2012, WORLD J PEDIATR CONG, V3, P229, DOI 10.1177/2150135111432771
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   Tortoriello TA, 2003, ANN THORAC SURG, V76, P1655, DOI 10.1016/S0003-4975(03)01025-7
NR 15
TC 1
Z9 1
U1 0
U2 3
PU BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
PI ATASEHIR
PA ORNEK MH DR SUPHI EZGI SK SARAY APT NO 11 D 6, ATASEHIR, ISTANBUL 34704,
   TURKEY
SN 1301-5680
J9 TURK GOGUS KALP DAMA
JI Turk Gogus Kalp Damar Cerrahisi Derg.
PD APR
PY 2017
VL 25
IS 2
BP 174
EP 179
DI 10.5606/tgkdc.dergisi.2017.13820
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EW6KX
UT WOS:000402620300002
OA hybrid
DA 2026-07-24
ER
PT J
AU Takahashi, Y
   Sasaki, Y
   Bito, Y
   Motoki, M
   Murakami, T
   Shibata, T
AF Takahashi, Yosuke
   Sasaki, Yasuyuki
   Bito, Yasuyuki
   Motoki, Manabu
   Murakami, Takashi
   Shibata, Toshihiko
TI Perigraft fluid collection mimicking graft infection in patients with a
   para-anastomotic aneurysm
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID SAC ENLARGEMENT; ENDOTENSION; CLASSIFICATION; REPAIR
AB We herein report two cases of perigraft effusion mimicking graft infection after debranching thoracic endovascular repair for an anastomotic pseudoaneurysm of the distal ascending aorta. Both patients presented with a bulging tumor on the sternum. Enhanced computed tomography showed no endoleak, but extension of periprosthetic graft fluid to a subcutaneous sternal wound was present. We suspected a deep sternal wound infection; however, cultures of debrided tissues were negative. After drainage of the subcutaneous fluid or negative pressure wound therapy, both patients were doing well without recurrence of effusion. Endotension was considered to have been associated with enlargement of the perigraft effusion.
C1 [Takahashi, Yosuke; Sasaki, Yasuyuki; Bito, Yasuyuki; Motoki, Manabu] Osaka City Gen Hosp, Div Cardiovasc Surg, Osaka, Japan.
   [Murakami, Takashi; Shibata, Toshihiko] Osaka City Univ, Grad Sch Med, Dept Cardiovasc Surg, Osaka, Japan.
C3 Osaka City General Hospital; Osaka Metropolitan University
RP Takahashi, Y (通讯作者)，Osaka City Gen Hosp, Dept Cardiovasc Surg, Miyakojima Ku, 2-13-22 Hondori Miyakojima, Osaka 5340021, Japan.
EM ysk@msic.med.osaka-cu.ac.jp
RI Takahashi, Yosuke/GPC-5174-2022; /AAH-8028-2019; Shibata,
   Toshihiko/ISB-3776-2023
OI Takahashi, Yosuke/0000-0003-2258-7204; 
CR Cerna M, 2009, J VASC SURG, V50, P648, DOI 10.1016/j.jvs.2009.04.044
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   White GH, 1997, J ENDOVASC SURG, V4, P152, DOI 10.1583/1074-6218(1997)004<0152:EAACOE>2.0.CO;2
NR 7
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD APR
PY 2017
VL 65
IS 4
BP 1189
EP 1191
DI 10.1016/j.jvs.2016.07.124
PG 3
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA EW6MT
UT WOS:000402625400037
PM 27751737
DA 2026-07-24
ER
PT J
AU Teixeira, S
   Costa, J
   Bartosch, I
   Correia, B
   Silva, A
AF Teixeira, Sergio
   Costa, Joana
   Bartosch, Isabel
   Correia, Bernardo
   Silva, Alvaro
TI Management of Pharyngocutaneous Fistula With Negative-Pressure Wound
   Therapy
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; pharyngocutaneous fistula;
   pharyngoesophageal reconstruction; total laryngectomy
ID VACUUM-ASSISTED CLOSURE; SYSTEM; HEAD; NECK
AB Background: Pharyngocutaneous fistula is a common complication of laryngopharyngeal surgery and is associated with increased morbidity and mortality. Beyond the classical management, negative-pressure wound therapy (NPWT) can be an alternative and effective treatment.
   Clinical Report: Two patients with pT3N0M0 squamous cell carcinoma of pyriform sinus were subjected to total laryngectomy and pharyngoesophageal reconstruction of a circular (patient 1) and an anterior wall defect (patient 2) with radial forearm free flap and pectoralis major muscle flap, respectively. Both developed a pharyngocutaneous fistula and NPWT was used.
   A significant decrease of the fistula aperture and exudate was observed after 22 and 21 days of NPWT in patients 1 and 2, respectively. After that standard wound care was instituted and closure of the fistulae was accomplished in 5 and 7 days, respectively.
   Conclusion: Negative-pressure wound therapy can be an effective treatment for pharyngocutaneous fistula closure, either in the setting of fistulae that persist besides multiple surgical revisions using muscle flaps or as a first-line therapy when fistulae develops.
C1 [Teixeira, Sergio; Costa, Joana; Bartosch, Isabel; Correia, Bernardo; Silva, Alvaro] Ctr Hosp Sao Joao, Dept Plast Reconstruct & Aesthet Surg & Burn Unit, Oporto, Portugal.
C3 Sao Joao Hospital
RP Teixeira, S (通讯作者)，Rua Cruz Vermelha 252, P-4580697 Oporto, Portugal.
EM sergioteixeira21@gmail.com
RI silva, alvaro/HDO-6977-2022
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NR 10
TC 16
Z9 19
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD JUN
PY 2017
VL 28
IS 4
BP E364
EP E367
DI 10.1097/SCS.0000000000003682
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EW8EG
UT WOS:000402750600020
PM 28328600
DA 2026-07-24
ER
PT J
AU Scheuermann-Poley, C
   Wagner, C
   Hoffmann, J
   Moter, A
   Willy, C
AF Scheuermann-Poley, C.
   Wagner, C.
   Hoffmann, J.
   Moter, A.
   Willy, C.
TI The significance of biofilm for the treatment of infections in
   orthopedic surgery. 2017 Update
SO UNFALLCHIRURG
LA German
DT Article
DE Implant-associated infections; Antiseptic agents; Negative pressure
   wound therapy instillation; Debridement; Fluorescence in situ
   hybridization
ID STAPHYLOCOCCUS-EPIDERMIDIS BIOFILM; IN-SITU HYBRIDIZATION; BONE-CEMENT;
   IMPLANT INFECTIONS; PSEUDOMONAS-AERUGINOSA; ANTIMICROBIAL PEPTIDES;
   PERIPROSTHETIC INFECTIONS; BACTERIAL BIOFILMS; INHIBITS BIOFILM; AUREUS
AB Background. The increase in endoprosthetic and osteosynthetic surgical treatment is associated with a simultaneous increase in implant-associated infections (surgical site infections, SSI). Biofilms appear to play a significant role in the diagnosis and treatment of these infections and heavily contaminated wounds. This article aims to provide a current overview of biofilm and its relevance in orthopedic surgery.
   Materials and methods. A computer-assisted literature search of MedLine (PubMed) was performed using key word combinations with "biofilm" (as of March 2017).
   Results. Biofilm, a polymicrobial organization and life form surrounded by a polysaccharide matrix, refers to an adaptation strategy of bacteria in unfavorable living conditions (e.g. under antibiotic therapy). Biofilms can develop after 6 h in highly contaminated wounds. In acute and chronic infections, biofilms can occur in 30-80 % of the cases. Only planktonic bacteria (high metabolic activity, cultivable) can be detected in standard microbiological cultures, biofilms, however, cannot. Molecular microscopic methods, such as fluorescence in situ hybridization (FISH), enable the detection of bacteria in biofilms. The core concepts of anti-biofilm therapy include the prevention of biofilm and early surgical debridement, followed by the local and/or systemic administration of antibiotics as well as the local application of antiseptics.
   Conclusions. The development of biofilm should be anticipated in strongly contaminated wounds as well as in acute and chronic infection sites. The best strategy to combat biofilms is to prevent their development. Standard microbiological culture methods do not enable the detection of biofilm. Therefore, the implementation of molecular biological detection methods (z. B. FISH) is important. Further anti-biofilm strategies are being investigated experimentally, but there are no real options for clinical use as of yet.
C1 [Scheuermann-Poley, C.] Bundeswehrkrankenhaus Berlin, Abt Unfallchirurg Orthopadie Sept & Plast Chirurg, Berlin, Germany.
   [Wagner, C.] Klinikum Ingolstadt, Zentrum Orthopadie & Unfallchirurg, Ingolstadt, Germany.
   [Hoffmann, J.; Moter, A.] Deutsch Herzzentrum Berlin, Biofilmzentrum, Berlin, Germany.
   [Willy, C.] Bundeswehrkrankenhaus Berlin, Klin Unfallchirurg, Sept Rekonstrukt Chirurg,Orthopadie, Forsch & Behandlungszentrum Sept Defektwunden, Scharnhorststr 13, D-10115 Berlin, Germany.
C3 German Heart Center Berlin
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Berlin, Klin Unfallchirurg, Sept Rekonstrukt Chirurg,Orthopadie, Forsch & Behandlungszentrum Sept Defektwunden, Scharnhorststr 13, D-10115 Berlin, Germany.
EM christianwilly@bundeswehr.org
RI Moter, Annette/IAL-9880-2023; /AAJ-3174-2021
OI Moter, Annette/0000-0003-1318-5780; 
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NR 140
TC 7
Z9 8
U1 0
U2 29
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD JUN
PY 2017
VL 120
IS 6
BP 461
EP 471
DI 10.1007/s00113-017-0361-y
PG 11
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA EW8TH
UT WOS:000402790500006
PM 28540567
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Izadpanah, K
   Hansen, S
   Six-Merker, J
   Helwig, P
   Südkamp, NP
   Schmal, H
AF Izadpanah, Kaywan
   Hansen, Stephanie
   Six-Merker, Julia
   Helwig, Peter
   Suedkamp, Norbert P.
   Schmal, Hagen
TI Factors influencing treatment success of negative pressure wound therapy
   in patients with postoperative infections after Osteosynthetic fracture
   fixation
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Infection; Osteosynthesis; Npwt; Vac; Clinical trial; Logistic
   regression models
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE RECONSTRUCTION; MANAGEMENT;
   MULTICENTER
AB Background: Negative Pressure Wound Therapy (NPWT) is being increasingly used to treat postoperative infections after osteosynthetic fracture fixation. The aim of the present study was to analyze the influence of epidemiological and microbiological parameters on outcome.
   Methods: Infections following operative fracture fixation were registered in a comprehensive Critical Incidence Reporting System and subsequently analyzed retrospectively for characteristics of patients including comorbidity, bacteria, and clinical factors. The influence of the investigated parameters was analyzed using logistic regression models based on data from 106 patients.
   Results: Staged wound lavage in combination with NPWT allowed implant preservation in 44% and led to successful healing in 73% of patients. Fermentation characteristics, load and behavior after gram staining revealed no statistically significant correlation with either healing or implant preservation. Infecting bacteria were successfully isolated in 87% of patients. 20% of all infections were caused by bacterial combinations. We observed a change in the infecting bacterial species under therapy in 23%. Age, gender, metabolic diseases or comorbidities did not influence the probability of implant preservation or healing. The delayed manifestation of infection (>4 weeks) correlated with a higher risk for implant loss (OR 5.1 [95% CI 1.41-17.92]) as did the presence of bacterial mixture (OR 5.0 [95% CI 1.41-17.92]) and open soft-tissue damage >= grade 3 (OR 10.2 [CI 1.88-55.28]). Wounds were less likely to heal in conjunction with high CRP blood levels (>20 mg/l) at the time of discharge (OR 3.6 [95% CI 1.31-10.08]) or following a change of the infecting bacterial species under therapy (OR 3.2 [95% CI, 1.13-8.99]).
   Conclusions: These results indicate that the delayed manifestation of infection, high CRP blood levels at discharge, and alterations in the infecting bacterial species under therapy raise the risk of NPWT failure.
C1 [Izadpanah, Kaywan; Hansen, Stephanie; Helwig, Peter; Suedkamp, Norbert P.; Schmal, Hagen] Univ Hosp Freiburg, Dept Orthoped & Trauma Surg, Freiburg, Germany.
   [Six-Merker, Julia] Helmholtz Zentrum Munchen, Munich, Germany.
   [Schmal, Hagen] Univ Southern Denmark, Dept Orthoped & Traumatol, Odense Univ Hosp, Sdr Blvd 29, DK-5000 Odense C, Denmark.
   [Schmal, Hagen] Univ Southern Denmark, Dept Clin Res, Sdr Blvd 29, DK-5000 Odense C, Denmark.
C3 University of Freiburg; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health; University of Southern
   Denmark; Odense University Hospital; University of Southern Denmark
RP Schmal, H (通讯作者)，Univ Hosp Freiburg, Dept Orthoped & Trauma Surg, Freiburg, Germany.; Schmal, H (通讯作者)，Univ Southern Denmark, Dept Orthoped & Traumatol, Odense Univ Hosp, Sdr Blvd 29, DK-5000 Odense C, Denmark.; Schmal, H (通讯作者)，Univ Southern Denmark, Dept Clin Res, Sdr Blvd 29, DK-5000 Odense C, Denmark.
EM hagen.schmal@freenet.de
RI Suedkamp, Norbert/AAF-2931-2019; Izadpanah, Kaywan/OGO-0168-2025;
   Schmal, Hagen/B-2684-2016
OI Schmal, Hagen/0000-0002-8801-2385
FU German Research Foundation (DFG); University of Freiburg in the funding
   program Open Access Publishing
FX The article processing charge was funded by the German Research
   Foundation (DFG) and the University of Freiburg in the funding program
   Open Access Publishing.
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NR 26
TC 6
Z9 8
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD JUN 7
PY 2017
VL 18
AR 247
DI 10.1186/s12891-017-1607-0
PG 10
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA EW9NO
UT WOS:000402846700002
PM 28592300
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Bocchiotti, MA
   Bogetti, P
   Parisi, A
   Rivarossa, F
   Frenello, A
   Baglioni, EA
AF Bocchiotti, M. A.
   Bogetti, P.
   Parisi, A.
   Rivarossa, F.
   Frenello, A.
   Baglioni, E. A.
TI Management of Fournier's gangrene non-healing wounds by autologous skin
   micrograft biotechnology: a new technique
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE Fournier gangrene; case study; Rigenera protocol; skin graft;
   non-healing wounds
ID DEHISCENCE
AB Fournier's gangrene is an acute bacterial infection producing necrosis of the perineum and external genitalia that generally affects elderly men. Although skin grafts and flaps are the standard procedure for reconstruction, sometimes wounds can become chronic. Rigenera Protocol is a new technique based on autologous skin micrografts that reactivates and supports wound healing. A 40-year-old male with Fournier's gangrene, due to a rectal microperforation following diarrhoea, was treated with surgical debridement, negative pressure wound therapy and subsequently coverage with skin grafts. He developed non-healing wounds treated by Rigenera protocol after two months of advanced wound dressings. This technique is based on skin micrografts obtained by mechanical dermal disgregation to provide mesenchymal stem cells and extracellular matrix to the wound. The suspension injected into the wound triggers reactivation of healing without significant residual scarring on both donor site and treated area. Non-healing wounds were reduced by 15% at day 7 and by 50% after 30 days. Wounds completely healed after seventy days. The regenerated tissue appeared closer to skin graft than to scar tissue. This report shows how the use of skin micrografts through Rigenera protocol can be a useful method to reactivate wound healing resulting from Fournier's gangrene, with no discomfort for patient in a practical, safe and easy way.
   Declaration of interest: The authors have no conflict of interest.
C1 [Bocchiotti, M. A.; Bogetti, P.; Parisi, A.; Rivarossa, F.; Frenello, A.; Baglioni, E. A.] Univ Turin, Dept Reconstruct & Plast Surg, Citta Salute & Sci Hosp, Turin, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino; University of Turin
RP Parisi, A (通讯作者)，Univ Turin, Dept Reconstruct & Plast Surg, Citta Salute & Sci Hosp, Turin, Italy.
EM andrea.parisi88@gmail.com
RI /AAM-3165-2021
OI Parisi, Anea/0009-0003-0147-9340
CR Alwaal A, 2015, UROLOGY, V86, P835, DOI 10.1016/j.urology.2015.07.005
   [Anonymous], STEM CELLS INT
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NR 22
TC 9
Z9 13
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2017
VL 26
IS 6
BP 314
EP 317
DI 10.12968/jowc.2017.26.6.314
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EX1TW
UT WOS:000403010300005
PM 28598758
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Barabino, G
   Filippello, A
   Brek, A
   Cuilleron, M
   Dumas, O
   Rinaldi, L
   Porcheron, J
AF Barabino, Gabriele
   Filippello, Alexandre
   Brek, Amine
   Cuilleron, Muriel
   Dumas, Olivier
   Rinaldi, Leslie
   Porcheron, Jack
TI Management of an Esojejunal Intrathoracic Leak Using an Endoscopic
   Vacuum-assisted Closure Technique
SO SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
LA English
DT Article
DE endoscopic vacuum-assisted closure; esojejunal anastomosis; leak;
   surgery
ID ANASTOMOTIC LEAK; STENT
AB Management of intrathoracic anastomotic leaks remains an important clinical challenge. We describe a case about a patient with intrathoracic esophageal anastomotic leaks after oesogastrectomy. Ndoscopic Vacuum-assisted closure technique today is an effective alternative in the treatment of anastomotic leaks after upper gastrointestinal tract surgery.
C1 [Barabino, Gabriele; Filippello, Alexandre; Brek, Amine; Porcheron, Jack] Univ Hosp St Etienne, Dept Digest & Oncol Surg, St Priest En Jarez, France.
   [Cuilleron, Muriel] Univ Hosp St Etienne, Dept Radiol, St Priest En Jarez, France.
   [Dumas, Olivier; Rinaldi, Leslie] Univ Hosp St Etienne, Gastroenterol Unit, St Priest En Jarez, France.
C3 CHU de St Etienne; CHU de St Etienne; CHU de St Etienne
RP Barabino, G (通讯作者)，Nord Hosp, Univ Hosp St Etienne, Dept Digest & Oncol Surg, Ave Albert Raymond, F-42270 St Priest En Jarez, France.
EM gabriele.barabino@chu-st-etienne.fr
CR Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Kassis ES, 2013, ANN THORAC SURG, V96, P1919, DOI 10.1016/j.athoracsur.2013.07.119
   Leers JM, 2009, SURG ENDOSC, V23, P2258, DOI 10.1007/s00464-008-0302-5
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   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 5
TC 1
Z9 3
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1530-4515
EI 1534-4908
J9 SURG LAPARO ENDO PER
JI Surg. Laparosc. Endosc. Pct. Tech.
PD JUN
PY 2017
VL 27
IS 3
BP e26
EP e27
DI 10.1097/SLE.0000000000000393
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EX2QU
UT WOS:000403072300002
PM 28383315
DA 2026-07-24
ER
PT J
AU Yang, LG
   Yang, YG
   Yang, XM
   Yang, TX
   Yang, YX
   Xie, JJ
AF Yang, Leigang
   Yang, Yungang
   Yang, Xiuming
   Yang, Tianxu
   Yang, Yuxuan
   Xie, Junjie
TI Free bone retention plus iliac bone grafting under phase I vacuum
   sealing drainage lavage for treatment of Gustilo type I, II, and IIIA
   open bone defects
SO BIOMEDICAL RESEARCH-INDIA
LA English
DT Article
DE Bone grafting; Open fracture; Bone defect; Treatment
ID FREE-FLAP TRANSPLANTATION; TIBIAL SHAFT FRACTURES; CATARACT-SURGERY;
   POVIDONE-IODINE; POSTTRAUMATIC OSTEOMYELITIS; MANAGEMENT; PRESSURE;
   THERAPY; ENDOPHTHALMITIS; CHLORHEXIDINE
AB This study aimed to investigate the treatment efficacy of free bone retention plus iliac bone grafting under phase I Vacuum Sealing Drainage (VAS) lavage for treatment of open bone defects. Thirty-six bone fractures were classified according to the Gustilo classification between January 2008 and April 2016. This study included 16 type I cases, 12 type II cases, and 8 type IIIA cases. Length of the longitudinal section of the damaged free crushed bone was 0.5 to 7.1 cm. There were 7 cases with sections <= 1 cm, 12 with sections 2 to 3 cm, 11 with sections 3 to 5 cm, and 6 with sections>5 cm. The rinse protocol comprised 3000 ml/d of saline for 3 days for Gustilo type I fractures, 6000 ml/day of saline for 5 days for Gustilo type II fractures, and 9000 ml/d of saline for 7 days for Gustilo type IIIA fractures. Fifty ml of Anerdian (type III, diluted 10 fold) was added by VSD treatment (closed negative-pressure lavage). Callus formation was seen within 3.5 months after surgery, with osseous union at an average of 6.5 months. The wound healed well in 35 cases. In l case, the patient developed superficial cellulitis near the screw path, which resolved after removing the external fixation device. There was no internal fixation loosening, breakage, or exposure. Non-union and osteomyelitis were not seen. This method could be effective to prevent infection, osteomyelitis, delayed union, and non-union.
C1 [Yang, Leigang; Xie, Junjie] Xianyang Ctr Hosp, Dept Orthopaed, Xianyang, Peoples R China.
   [Yang, Yungang; Yang, Xiuming; Yang, Tianxu; Yang, Yuxuan] Xianyang Yangsa Hosp, Dept Pain, Xianyang, Peoples R China.
RP Yang, YG (通讯作者)，Xianyang Yangsa Hosp, Dept Pain, Xianyang, Peoples R China.
RI Junjie, Xie/AHD-4060-2022; Yuxuan, Yang/LBI-0448-2024
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NR 35
TC 1
Z9 1
U1 1
U2 4
PU ALLIED ACAD
PI LONDON
PA 40 BLOOMSBURY WAY, LOWER GROUND FLR, LONDON, WC1A 2SE, ENGLAND
SN 0970-938X
EI 0976-1683
J9 BIOMED RES-INDIA
JI Biomed. Res.-India
PY 2017
VL 28
IS 6
BP 2456
EP 2461
PG 6
WC Engineering, Biomedical; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Research & Experimental Medicine
GA EX7SI
UT WOS:000403448200014
DA 2026-07-24
ER
PT J
AU Saul, D
   Dresing, K
AF Saul, D.
   Dresing, K.
TI Treatment of traumatic lesions of the bursa olecrani and chronic
   bursitis olecrani
SO OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE
LA German
DT Article
DE Bursectomy; Bursitis; Elbow; Olecranon; Wound healing
ID SEPTIC BURSITIS; PREPATELLAR BURSITIS; MANAGEMENT; DIAGNOSIS; WOUNDS;
   EMERGENCY; CLOSURE
AB Complete olecranon bursectomy with debridement, protection of veins and nerves. Risk-adapted antibiotic therapy and early functional aftercare.
   Acute, traumatic laceration of the bursa olecrani, chronic therapy-resistant bursitis olecrani.
   For traumatic bursa injuries: general contraindications for anesthesia and surgery; chronic bursitis: initially not closable skin defect (plastic surgery required), hemodynamically instable patient (e.g. systemic inflammatory response syndrome [SIRS] or sepsis), pre-existing skin infection.
   Local anesthesia beyond the lesion, careful debridement, identification and removal of the entire bursa, excision of contaminated skin, lavage, drain insertion (Redon, Easy-flow, Penrose). Wound closure, elastic bandage, and splint.
   Elastic bandage for 2 days, followed by drain removal. Wound assessment, early functional aftercare without splint, antibiotic therapy in septic bursitis for 2 weeks, PRICE scheme. Removal of stitches after 10-12 days.
   Over 5 years, 138 cases of traumatic bursa lesion or chronic bursitis olecrani were treated in our clinic, 82 patients underwent surgery. Ten patients were treated with vacuum-assisted closure therapy and consecutive wound healing; fistulae occurred in two patients and in another two dehiscence developed. All of the defects could be closed without flaps.
C1 [Saul, D.; Dresing, K.] Univ Med Gottingen, Klin Unfallchirurg Orthopadie & Plast Chirurg, Robert Koch Str 40, D-37075 Gottingen, Germany.
C3 University of Gottingen
RP Saul, D (通讯作者)，Univ Med Gottingen, Klin Unfallchirurg Orthopadie & Plast Chirurg, Robert Koch Str 40, D-37075 Gottingen, Germany.
EM Dominik.Saul@med.uni-goettingen.de
RI Saul, Dominik/K-7355-2019; Dresing, Klaus/I-1781-2019
OI Saul, Dominik/0000-0002-0673-3710; 
CR Aaron DL, 2011, J AM ACAD ORTHOP SUR, V19, P359, DOI 10.5435/00124635-201106000-00006
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NR 43
TC 1
Z9 1
U1 0
U2 4
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0934-6694
EI 1439-0981
J9 OPER ORTHOP TRAUMATO
JI Oper. Orthopade Traumatol.
PD JUL
PY 2017
VL 29
IS 3
BP 253
EP 265
DI 10.1007/s00064-017-0483-y
PG 13
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA EX8NB
UT WOS:000403505900006
PM 28175943
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Bleszynski, MS
   Chan, T
   Buczkowski, AK
AF Bleszynski, Michael S.
   Chan, Tiffany
   Buczkowski, Andrzej K.
TI Comparison of inflammatory cytokines in peritoneal fluid at source
   control surgery for abdominal sepsis
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID HEPATOCYTE GROWTH-FACTOR; MORTALITY; RESPONSES; THERAPY; INJURY; CELLS
AB Background: Open abdomen with vacuum assisted closure (VAC) is an alternate method to primary abdominal closure (PAC) in select situations for the management of severe surgical abdominal sepsis or septic shock. Peritoneal cytokines may potentially correlate with deranged physiology and help stratify severity of sepsis. The primary objective of the study was to identify if cytokines can differentiate between patients who underwent PAC or VAC at primary source control laparotomy (SCL).
   Methods: Prospective case series including patients with severe abdominal sepsis/septic shock requiring urgent SCL. Peritoneal fluid (PF) was collected intra-operatively and blood samples were collected pre- and post SCL. Samples were analyzed with a Cytokine 30-plex Panel. APACHE-IV was used as a measure of disease severity between groups.
   Results: 4 PAC and 8 VAC patients were included. PF concentrations of IL 6, IL-17, IL-5 and HGF were significantly elevated in VAC compared to PAC. Serum RANTES was increased in survivors compared to non-survivors.
   Conclusions: Patients who received VAC management had a more severe degree of local abdominal sepsis based on significantly elevated peritoneal cytokines. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Bleszynski, Michael S.; Chan, Tiffany; Buczkowski, Andrzej K.] Univ British Columbia, Dept Gen Surg, Div Gen Surg, Vancouver, BC, Canada.
C3 University of British Columbia
RP Bleszynski, MS (通讯作者)，Univ British Columbia, Fac Med, Dept Surg, Div Gen Surg,Vancouver Gen Hosp, Rm 3100 Jim Pattison Pavill North, Vancouver, BC V5Z 1M9, Canada.
EM mbleszyn@gmail.com
CR Campbell A, 2009, AM SURGEON, P75
   Chu VT, 2014, IMMUNITY, V40, P582, DOI 10.1016/j.immuni.2014.02.014
   Coccolini F, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0026-5
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NR 30
TC 7
Z9 7
U1 0
U2 4
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2017
VL 213
IS 5
BP 849
EP 855
DI 10.1016/j.amjsurg.2017.03.037
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EY4HJ
UT WOS:000403937900004
PM 28456342
DA 2026-07-24
ER
PT J
AU Schalamon, J
   Petnehazy, T
   Ainoedhofer, H
   Castellani, C
   Till, H
   Singer, G
AF Schalamon, Johannes
   Petnehazy, Thomas
   Ainoedhofer, Herwig
   Castellani, Christoph
   Till, Holger
   Singer, Georg
TI Experimental comparison of abdominal drainage systems
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Abdominal drainage; Experimental; Redon; Jackson; VAC
ID PERFORATED APPENDICITIS; APPENDECTOMY; CHILDREN
AB Background: In an experimental study the performance of different closed abdominal drainage systems was tested.
   Methods: A vacuum bottle designed for Redon Drainage, a flexible plastic bulb designed for Jackson-Pratt drains and a V.A.C.(R) Negative Pressure Wound Therapy System were used. In a porcine cadaveric study mimicking the abdominal cavity the intrinsic pressure (IP) at one and three minutes (T0, T3) and the amount of evacuated fluid were measured.
   Results: The Redon and Jackson drainage displayed a rapid decline to IP values of almost zero comparing T0 and T3. Only the V.A.C.(R) system was able to preserve constant values of negative IP values measured at both time points. Only the V.A.C.(R) system was able to remove almost the whole amount of inserted fluid.
   Conclusions: In an experimental setting the V.A.C.(R) system was superior to the other two tested systems in delivering constant negative IP and the amount of evacuated fluid. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Schalamon, Johannes; Petnehazy, Thomas; Ainoedhofer, Herwig; Castellani, Christoph; Till, Holger; Singer, Georg] Med Univ Graz, Dept Paediat & Adolescent Surg, Auenbruggerpl, Graz, Austria.
C3 Medical University of Graz
RP Singer, G (通讯作者)，Med Univ Graz, Dept Paediat & Adolescent Surg, Auenbruggerpl, Graz, Austria.
EM georg.singer@medunigraz.at
RI /B-2703-2010
OI Singer, Georg/0000-0003-4770-3144
CR Akkoyun I, 2012, J PEDIATR SURG, V47, P1886, DOI 10.1016/j.jpedsurg.2012.03.049
   Beek MA, 2015, SPRINGERPLUS, V4, DOI 10.1186/s40064-015-1154-9
   DOUGHERTY SH, 1992, CURR PROB SURG, V29, P561
   Grobmyer Stephen R, 2002, Surg Infect (Larchmt), V3, P245, DOI 10.1089/109629602761624207
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   Pakula AM, 2014, AM SURGEON, V80, P1078
   Reiffel AJ, 2013, SURG INFECT, V14, P244, DOI 10.1089/sur.2011.126
   Scevola S, 2002, ANN PLAS SURG, V48, P511, DOI 10.1097/00000637-200205000-00011
   Song RY, 2015, ANN SURG TREAT RES, V88, P341, DOI 10.4174/astr.2015.88.6.341
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   Wong CS, 2015, INT J SURG, V23, P87, DOI 10.1016/j.ijsu.2015.09.033
NR 13
TC 2
Z9 2
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD JUN
PY 2017
VL 213
IS 6
BP 1038
EP 1041
DI 10.1016/j.amjsurg.2016.09.043
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EY4HW
UT WOS:000403939400008
PM 27765183
DA 2026-07-24
ER
PT J
AU Maguire, CR
   Livingston, R
   Phillips, GE
   Kimble, RM
AF Maguire, Christopher R.
   Livingston, Ryan
   Phillips, Gael E.
   Kimble, Roy M.
TI Giant congenital melanocytic nevi and malignant transformation: a case
   for early radical intervention
SO PEDIATRIC SURGERY INTERNATIONAL
LA English
DT Article
DE Congenital melanocytic nevus; Integra; Negative pressure wound therapy;
   Malignant transformation
ID MELANOMA; CLOSURE; RISK
AB The purpose of this paper is to highlight the risk of early malignant transformation in infants with giant congenital melanocytic nevi (GN) and demonstrate the potential for earlier intervention with aggressive surgery. We describe the case of a child born with a GN who developed a metastatic melanoma early in life, despite early commencement of resection of the nevus. This is contrasted against a second case of a child in which a more radical management was conducted. Despite early commencement of serial resection of the GN, the first child in this series died of metastatic melanoma prior to complete excision of the nevus. With the second child, radical excision combined with the use of Integra (TM) and negative pressure wound therapy allowed total removal of the GN within the first 6 months of life.
C1 [Maguire, Christopher R.] Mater Hosp, Brisbane, Qld, Australia.
   [Livingston, Ryan] Princess Alexandra Hosp, Brisbane, Qld, Australia.
   [Phillips, Gael E.] CCHR, Cent Lab Herston, Pathol Queensland, Brisbane, Qld, Australia.
   [Kimble, Roy M.] Lady Cilento Childrens Hosp, Ctr Childrens Burns & Trauma Res, Brisbane, Qld, Australia.
C3 Mater Health Services; Mater Hospital Brisbane; Princess Alexandra
   Hospital; Childrens Health Queensland Hospital & Health Service;
   Queensland Childrens Hospital
RP Maguire, CR (通讯作者)，Mater Hosp, Brisbane, Qld, Australia.
EM christopher.r.maguire@gmail.com; Drryanlivingston@hotmail.co.uk;
   gael.phillips@health.qld.gov.au; royk@uq.edu.au
RI ; Kimble, Roy/B-4160-2011
OI Maguire, Christopher/0000-0002-4179-2089; 
CR Abadi B, 2004, PLAST RECONSTR SURG, V114, P162
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Hunter Judith E, 2007, Int Wound J, V4, P256, DOI 10.1111/j.1742-481X.2007.00361.x
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   Marghoob AA, 1996, ARCH DERMATOL, V132, P170, DOI 10.1001/archderm.132.2.170
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NR 11
TC 6
Z9 7
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-0358
EI 1437-9813
J9 PEDIATR SURG INT
JI Pediatr. Surg. Int.
PD JUL
PY 2017
VL 33
IS 7
BP 823
EP 827
DI 10.1007/s00383-017-4095-2
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA EY8IQ
UT WOS:000404238600014
PM 28508099
DA 2026-07-24
ER
PT J
AU Newton, NJ
   Sharrock, A
   Rickard, R
   Mughal, M
AF Newton, N. J.
   Sharrock, A.
   Rickard, R.
   Mughal, M.
TI Systematic review of the use of endo-luminal topical negative pressure
   in oesophageal leaks and perforations
SO DISEASES OF THE ESOPHAGUS
LA English
DT Article
DE esophageal perforation; negative pressure wound therapy; vacuum assisted
   closure; wound healing
ID ENDOSCOPIC VACUUM THERAPY; UPPER GASTROINTESTINAL-TRACT; ANASTOMOTIC
   LEAKAGE; ASSISTED CLOSURE; TREATMENT OPTIONS; MANAGEMENT
AB Topical negative pressure is widely used in the management of superficial wounds. The use of this technology in the management of oesophageal perforations is becoming increasingly common. This systematic review aims to capture available evidence about its use in this setting. Medline and Embase were searched using MeSH terms and free text: esophageal perforation; esophageal injury; vacuum assisted closure; vacuum therapy device; esophagus; wounds penetrating; esophageal perforation; wound healing; negative pressure wound therapy. Searches were carried out between April and November 2015. Case series, cohort trials and controlled trials were included. Additional studies were found by hand searching reference lists. Eleven studies met the inclusion criteria with 180 patients. Nine of the studies were case series and two were retrospective comparisons of negative pressure with stents or clips. Healing of the perforation occurred in 163/179 patients and the overall mortality was 12.8%. Compared with published data on mortality from oesophageal perforation, the application of negative pressure appears to be beneficial. The studies are, however, limited to case series and retrospective cohort studies. The number of patients in each study is small and in the absence of randomized trials demonstrating a lack of bias firm conclusions cannot be made.
C1 [Newton, N. J.; Mughal, M.] Univ Coll Hosp, Gastrointestinal Serv, London, England.
   [Sharrock, A.] Imperial Coll, Ctr Blast Injury Studies, London, England.
   [Rickard, R.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
C3 University of London; University College London; Imperial College
   London; Royal Centre for Defence Medicine
RP Newton, NJ (通讯作者)，169 Viridian Apartments 75 Battersea Pk Rd, London SW8 4DB, England.
EM nicknewton1@aol.com
CR Biancari F, 2013, WORLD J SURG, V37, P1051, DOI 10.1007/s00268-013-1951-7
   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Brinster CJ, 2004, ANN THORAC SURG, V77, P1475, DOI 10.1016/j.athoracsur.2003.08.037
   Dasari BVM, 2014, ANN SURG, V259, P852, DOI 10.1097/SLA.0000000000000564
   Glitsch A, 2008, ENDOSCOPY, V40, P192, DOI 10.1055/s-2007-995384
   Heits N, 2014, ANN THORAC SURG, V97, P1029, DOI 10.1016/j.athoracsur.2013.11.014
   Kuehn F, 2012, J GASTROINTEST SURG, V16, P2145, DOI 10.1007/s11605-012-2014-3
   Laukoetter MG, 2014, J AM COLL SURGEONS, V219, pE98, DOI 10.1016/j.jamcollsurg.2014.07.646
   Lemmers A, 2014, TECH GASTROINTEST EN, V16, P79, DOI 10.1016/j.tgie.2014.04.001
   Loske G, 2010, SURG ENDOSC, V24, P2531, DOI 10.1007/s00464-010-0998-x
   Mennigen R, 2014, WORLD J GASTROENTERO, V20, P7767, DOI 10.3748/wjg.v20.i24.7767
   Schniewind B, 2011, ENDOSCOPY, V43, pE64, DOI 10.1055/s-0030-1255799
   Schniewind B, 2013, SURG ENDOSC, V27, P3883, DOI 10.1007/s00464-013-2998-0
   Schorsch T, 2014, CHIRURG, V85, P1081, DOI 10.1007/s00104-014-2764-4
   Schorsch T, 2013, SURG ENDOSC, V27, P2040, DOI 10.1007/s00464-012-2707-4
   Smallwood NR, 2016, SURG ENDOSC, V30, P2473, DOI 10.1007/s00464-015-4501-6
   Tan B, 2015, GUT, V64, pA120, DOI 10.1136/gutjnl-2015-309861.245
   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Wedemeyer J, 2010, GASTROINTEST ENDOSC, V71, P382, DOI 10.1016/j.gie.2009.07.011
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   Wu JT, 2007, J TRAUMA, V63, P1173, DOI 10.1097/TA.0b013e31805c0dd4
NR 22
TC 36
Z9 50
U1 1
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1442-2050
J9 DIS ESOPHAGUS
JI Dis. Esophagus
PD MAR
PY 2017
VL 30
IS 3
DI 10.1111/dote.12531
PG 5
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EY8TY
UT WOS:000404271900023
PM 27628015
OA Bronze
DA 2026-07-24
ER
PT J
AU Chen, WJ
   Guo, H
   Chen, G
   Wang, WB
   Zhang, TP
AF Chen, Wei-Jie
   Guo, Hao
   Chen, Ge
   Wang, Wei-Bin
   Zhang, Tai-Ping
TI Successful control of high-flow output enterocutaneous fistula wound
   with an innovative self-manufactured plug
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE case report; high-flow output enterocutaneous fistula; wound care;
   self-manufactured plug
AB Background: Meticulous wound care is necessary for relieving the suffering of enterocutaneous fistula (ECF) patients and improving the quality of life. Although many approaches to treat the fistula wound have been attempted, wound care before definitive surgery remains a challenge, especially for high-flow output ECF. Cases: In the present study, we report a case of a 77-year-old female with a diagnosis of jejunal fistula 14 days after the Miles surgery. The traditional vacuum assisted closure (VAC) device was initially applied to the patient's wound care. However, the residual enteric fluid out from the fistula irritated skin and brought great pain (Visual Analogue Score 8). Morphine (20-30 mg daily) was used. Besides, the VAC system was replaced nearly every day because skin exudation led to poor airtightness and the evacuation tube was often blocked. In the following month, the wound size didn't change significantly. To reduce bowel fluid irritation and promote wound healing, we established a selfmanufactured plug to occlude the fistula, collect enteric fluid, and protect the wound. The patient did not complain any severe discomfort. No pain killer was used any more (Visual Analogue Score 3). The catheter of the plug collected 500-800 ml enteric fluid per 24 hours without blockade. In addition, all the materials to make the plug are cheap and available in the wards. After approximately 2 weeks of regular wound dressing changes, the fistula wound formed scabs and healed well. Conclusions: We present a case of successful control of high-flow output enterocutaneous fistula wound using an innovative self-manufactured plug. We highly recommend this pain-relieving and cost-effective approach for fistula wound care.
C1 [Chen, Wei-Jie; Guo, Hao; Chen, Ge; Wang, Wei-Bin; Zhang, Tai-Ping] Chinese Acad Med Sci, Dept Surg, Peking Union Med Coll Hosp, Shuaifuyuan 1, Beijing 100730, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital
RP Zhang, TP (通讯作者)，Chinese Acad Med Sci, Dept Surg, Peking Union Med Coll Hosp, Shuaifuyuan 1, Beijing 100730, Peoples R China.
EM zhangtppumch@163.com
CR Vallejo EC, 2015, DIAGN INTERV RADIOL, V21, P247, DOI 10.5152/dir.2014.14421
   Draus Jr JM, 2006, SURGERY, V140
   Hollington P, 2004, BRIT J SURG, V91, P1646, DOI 10.1002/bjs.4788
   Jr Draus JM, 2006, SURGERY, V140, P570
   Wainstein Daniel Edgardo, 2008, World J Surg, V32, P430
NR 5
TC 0
Z9 0
U1 0
U2 0
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 6
BP 9704
EP 9707
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EZ2JF
UT WOS:000404534900132
DA 2026-07-24
ER
PT J
AU Magalini, S
   Pepe, G
   Cozza, V
   Tilli, P
   La Greca, A
   Longo, F
   Gui, D
AF Magalini, S.
   Pepe, G.
   Cozza, V.
   Tilli, P.
   La Greca, A.
   Longo, F.
   Gui, D.
TI Negative pressure wound therapy (NPWT) in duodenal breakdown fistulas:
   negative pressure fistula therapy (NPFT)?
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE NPWT; Negative pressure; Wound therapy; Duodenal fistula
ID MANAGEMENT; SURGERY; COMPLICATIONS; GASTRECTOMY; CLOSURE; RESCUE
AB OBJECTIVE: To describe for the first time in literature the specific methodology of use of negative pressure wound therapy (NPWT) for duodenal fistula through clinical cases. The constant increase of use of NPWT for complex surgical situations imposes tailored previously undescribed solutions for the technique.
   PATIENTS AND METHODS: Herein, three cases of high output duodenal fistula successfully treated with Negative Pressure Wound Therapy (NPWT) are reported. The technical details for the application of NPWT to these fistulas are discussed and described.
   RESULTS: All three patients recovered without the necessity of further surgical operations.
   CONCLUSIONS: When using NPWT, management of high-output duodenal fistulas must rely on some degree of customization of the aspiration systems. The aim of the procedure is to put under depression the duodenal hole and surrounding tissues "all in one" and not to separate the complex wound in sectors as usually indicated. We suggest calling this technique Negative Pressure Fistula Therapy.
C1 [Magalini, S.; Pepe, G.; Cozza, V.; La Greca, A.; Longo, F.; Gui, D.] Univ Cattolica Sacro Cuore, Emergency Surg Dept, Fdn Policlin A Gemelli, Sch Med, Rome, Italy.
   [Tilli, P.] Univ Cattolica Sacro Cuore, Sch Med, Emergency Med Dept, Fdn Policlin A Gemelli, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Pepe, G (通讯作者)，Univ Cattolica Sacro Cuore, Emergency Surg Dept, Fdn Policlin A Gemelli, Sch Med, Rome, Italy.
EM gildapepe@yahoo.it
RI La Greca, Antonio/V-2593-2018; Longo, Francesco/AAE-5148-2021
CR ALBRIGHT HL, 1950, ANN SURG, V132, P49
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NR 26
TC 5
Z9 7
U1 0
U2 6
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD MAY
PY 2017
VL 21
IS 10
BP 2452
EP 2457
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EZ3ZP
UT WOS:000404650900021
PM 28617541
DA 2026-07-24
ER
PT J
AU Kantak, NA
   Mistry, R
   Varon, DE
   Halvorson, EG
AF Kantak, Neel A.
   Mistry, Riyam
   Varon, David E.
   Halvorson, Eric G.
TI Negative Pressure Wound Therapy for Burns
SO CLINICS IN PLASTIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Burns; Skin graft; VAC
ID THICKNESS SKIN-GRAFTS; CLOSURE; INTEGRA
AB Negative pressure wound therapy (NPWT) has become a widely used treatment for acute and chronic wounds. NPWT is indicated for a variety of complex wounds, and some studies validate its use for certain aspects of burn care. Although further research is needed to explore the benefits for burns, NPWT has proven beneficial in its use as a dressing that bolsters skin grafts, promotes integration of bilaminate dermal substitutes, promotes re-epithelialization of skin graft donor sites, and potentially reduces the zone of stasis. This article reviews the literature on NPWT in burns, based on indication/application, and describes our experience with the use of modified NPWT for large burns.
C1 [Kantak, Neel A.] Largo Med Ctr, MidaAtlantic Permanente Med Grp, 1221 Upper Mercantile Lane, Upper Marlboro, MD 20774 USA.
   [Mistry, Riyam] Royal Devon & Exeter Hosp NHS Fdn Trust, Dept Plast Surg, Exeter EX2 5DW, Devon, England.
   [Varon, David E.] Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   [Halvorson, Eric G.] Plast Surg Ctr Asheville, 5 Livingston St, Asheville, NC 28801 USA.
C3 Permanente Medical Groups; Harvard University; Harvard University
   Medical Affiliates; Brigham & Women's Hospital
RP Halvorson, EG (通讯作者)，Plast Surg Ctr Asheville, 5 Livingston St, Asheville, NC 28801 USA.
EM eric.halvorson@gmail.com
CR Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
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NR 22
TC 51
Z9 62
U1 5
U2 19
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0094-1298
EI 1558-0504
J9 CLIN PLAST SURG
JI Clin. Plast. Surg.
PD JUL
PY 2017
VL 44
IS 3
BP 671
EP +
DI 10.1016/j.cps.2017.02.023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EZ4OR
UT WOS:000404692900026
PM 28576256
DA 2026-07-24
ER
PT J
AU Kähler, G
AF Kaehler, Georg
TI Anastomotic Leakage after Upper Gastrointestinal Surgery: Endoscopic
   Treatment
SO VISCERAL MEDICINE
LA English
DT Review
DE Anastomotic leakage; Endoscopic management; EndoVAC therapy;
   Self-expanding metal stents; Clipping
ID VACUUM-ASSISTED CLOSURE; RESECTION; DEVICE
AB Anastomotic leakages substantially influence the outcome of patients after major surgery of the upper gastrointestinal tract. Endoscopy is important for making a diagnosis and for managing anastomotic leakages. By means of endoscopic inspection of the anastomotic site, not only the size and position of dehiscences but also the blood supply of the anastomotic region and an imminent leakage can be assessed. To close anastomotic leakages, several therapeutic methods are available, i.e. stenting, clipping, and the application of glue. In the majority of cases, the endoscopic application of a sponge for permanent suction (endoscopic vacuum-assisted closure therapy) is promising. (C) 2017 S. Karger GmbH, Freiburg
C1 [Kaehler, Georg] Heidelberg Univ, Med Ctr Mannheim, Cent Interdisciplinary Endoscopy, Mannheim, Germany.
C3 Ruprecht Karls University Heidelberg
RP Kähler, G (通讯作者)，Univ Med Mannheim, ZIE, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
EM georg.kaehler@umm.de
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   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 14
TC 22
Z9 27
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2297-4725
EI 2297-475X
J9 VISC MED
JI Visc. Med.
PY 2017
VL 33
IS 3
BP 202
EP 206
DI 10.1159/000475783
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA EZ5IE
UT WOS:000404746800005
PM 28785568
OA Bronze
DA 2026-07-24
ER
PT J
AU Singh, D
   Gowda, AU
   Chopra, K
   Tholen, M
   Chang, S
   Mavrophilipos, V
   Semsarzadeh, N
   Rasko, Y
   Holton, L
AF Singh, Devinder
   Gowda, Arvind U.
   Chopra, Karen
   Tholen, Michael
   Chang, Sarah
   Mavrophilipos, Vasilios
   Semsarzadeh, Nina
   Rasko, Yvonne
   Holton, Luther, III
TI The Effect of Negative Pressure Wound Therapy With Antiseptic
   Instillation on Biofilm Formation in a Porcine Model of Infected Spinal
   Instrumentation
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE spinal infection secondary spinal surgery; biofilm; negative pressure
   wound therapy
ID IMPLANT INFECTIONS; RESISTANT SURFACES; LUMBAR FUSIONS; CLOSURE;
   MANAGEMENT; BIOMATERIALS; DEVICE
AB Objective. This study evaluates the effect of negative pressure wound therapy with antiseptic instillation (NPWTi) in the clearance of infection and biofilm formation in an in vivo model of infected spinal implants compared to traditional treatment modalities. Materials and Methods. Five pigs underwent titanium rod implantation of their spinous processes followed by injection of 1 x 10(6) CFUs/100 mu L of methicillinresistant Staphylococcus aureus through the fascia at each site. At 1 week postoperatively, an experimental arm of 3 pigs received NPWTi, and a control arm of 2 pigs received wet-to-dry dressings. The persistence of local infection in the experimental group was compared to the control group using tissue cultures. Biofilm development on spinal implants was evaluated using scanning electron microscopy. Results. Mean bacterial count showed a statistical difference between the experimental and the control groups (P < .05). Scanning electron microscopy revealed the presence Of uniform biofilm formation across the surface of control group instrumentation, whereas the experimental group showed interrupted areas between biofilm formations. Conclusion. The authors concluded that NPWTi is associated with decreased bacterial load and biofilm formation compared to wet-to-dry dressings in an in vivo porcine model of infected spinal instrumentation.
C1 [Singh, Devinder; Rasko, Yvonne; Holton, Luther, III] Anne Arundel Med Ctr, Div Plast Surg, 2001 Med Pkwy, Annapolis, MD 21401 USA.
   [Gowda, Arvind U.] Yale Univ, Sch Med, Sect Plast & Reconstruct Surg, New Haven, CT USA.
   [Chopra, Karen; Tholen, Michael; Chang, Sarah; Mavrophilipos, Vasilios; Semsarzadeh, Nina] Univ Maryland, Sch Med, Div Plast & Reconstruct Surg, Baltimore, MD 21201 USA.
   [Chopra, Karen] Johns Hopkins Univ Hosp, Dept Plast & Reconstruct Surg, Baltimore, MD 21287 USA.
C3 Yale University; University System of Maryland; University of Maryland
   Baltimore; Johns Hopkins University; Johns Hopkins Medicine
RP Singh, D (通讯作者)，Anne Arundel Med Ctr, Div Plast Surg, 2001 Med Pkwy, Annapolis, MD 21401 USA.
EM dsingh@aahs.org
RI Singh, Devinder/AAN-4716-2021
FU Acelity
FX Dr. Singh is a consultant for KCI, An Acelity Company (San Antonio, TX).
   This work was supported by a research grant from Acelity. This device is
   not US Food and Drug Administration-approved for the indication that is
   the subject of this manuscript.
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NR 39
TC 13
Z9 15
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2017
VL 29
IS 6
BP 175
EP 180
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EZ9OP
UT WOS:000405060000005
PM 28267679
DA 2026-07-24
ER
PT J
AU von Beckerath, O
   Zapenko, A
   Dissemond, J
   Kröger, K
AF von Beckerath, Olga
   Zapenko, Alexander
   Dissemond, Joachim
   Kroeger, Knut
CA Initiative Chronische Wunden ICW
TI Ten-year analyses of the German DRG data about negative pressure wound
   therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Joints; Mediastinum; Negative pressure wound treatment; Pressure ulcer;
   Sternum; Thorax
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; QUALITY
AB Exact data regarding the clinical role of negative pressure wound therapy (NPWT) for wound care in a specific country are not available. Thus, we analysed the use of NPWT in hospitalised patients in Germany.
   Detailed lists of all hospitalised cases treated with NPWT in Germany for each of the years from 2005 to 2014 were obtained from the Federal Statistical Office, as well as lists of the 15 most frequent principal and additional diagnoses documented with NPWT in 2014.
   Within the 10-year time period of the study, the number of cases treated with NPWT increased by 349%, from 37 053 in 2005 to 129 269 in 2014. The rate of all hospitalised cases treated with NPWT increased form 0.22% to 0.66% in Germany.
   In 2014, wounds affecting skin and subcutaneous tissue (5-916.a0) are the most frequent documented indication for NPWT followed by deep wounds involving bones and joints at the limbs (5-916.a1). Open abdomens (5-916.a3) count for higher numbers than deep wounds of the thorax, mediastinum and sternum (5-916.a2). Fifty percent of all cases hospitalised for stage IV pressure ulcers at sacrum or ischium and around one third (32.2%) of cases with pyothorax received NPWT. Every fourth to fifth case hospitalised for disruption of surgical wounds or infections following a procedure (24.1%), as well as for infections and inflammations because of internal joint prosthesis or because of an internal fixation device was treated with NPWT (22.9%). In cases with diabetic foot syndrome, it is still every tenth case ( 10.1%).
   This analysis shows a substantial increase in the use of NPWT in the last decade for hospitalised patients. NPWT has a fixed role in the treatment of stage IV pressure ulcers at sacrum or ischium, pyothorax, infection and inflammation because of internal joint prosthesis or an internal fixation device and diabetic foot syndrome.
C1 [von Beckerath, Olga; Zapenko, Alexander; Kroeger, Knut] HELIOS Klin Krefeld GmbH, Dept Vasc Med, Lutherpl 40, D-47805 Krefeld, Germany.
   [Dissemond, Joachim] Univ Essen Gesamthsch, Dept Dermatol Venerol & Allergol, Essen, Germany.
C3 Helios Kliniken; University of Duisburg Essen
RP Kröger, K (通讯作者)，HELIOS Klin Krefeld GmbH, Dept Vasc Med, Lutherpl 40, D-47805 Krefeld, Germany.
EM knut.kroeger@helios-kliniken.de
RI Dissemond, Joachim/AFG-0691-2022
CR [Anonymous], 2015, COCHRANE DB SYST REV
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NR 24
TC 10
Z9 11
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2017
VL 14
IS 3
BP 501
EP 507
DI 10.1111/iwj.12635
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FA0BM
UT WOS:000405095800008
PM 27374835
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ropski, MK
   Guillaumin, J
   Monnig, AA
   Townsend, K
   McLoughlin, MA
AF Ropski, Meaghan K.
   Guillaumin, Julien
   Monnig, Andrea A.
   Townsend, Katy
   McLoughlin, Mary A.
TI Use of cryopoor plasma for albumin replacement and continuous
   antimicrobial infusion for treatment of septic peritonitis in a dog
SO JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
LA English
DT Article
DE canine; colloids; hydroxyethyl starch; sepsis
ID CRITICALLY-ILL PATIENTS; BETA-LACTAM ANTIBIOTICS; SEVERE SEPSIS; RENAL
   DYSFUNCTION; PHARMACOKINETICS; TRANSFUSION; IMIPENEM; EFFICACY; FLUID;
   RISK
AB Objective - To report the successful management of a dog with septic peritonitis and septic shock secondary to enterectomy dehiscence using novel techniques for identification of intestinal dehiscence and for septic shock treatment.
   Case Summary - A5-year-old castrated male Bernese Mountain Dog presented for lethargy 6 days following enterotomy for foreign body obstruction. Septic peritonitis was identified due to dehiscence of the enterotomy site, and resection and anastomosis were performed using a gastrointestinal anastomosis and thoracoabdominal stapling device. Postoperatively the patient experienced severe hypotension, which responded to norepinephrine constant rate infusion (CRI) after failing to improve with fluid therapy or dopamine CRI. Further treatment included antimicrobial CRI and supportive care including careful fluid therapy. Due to low effective circulating volume paired with intersititial fluid overload and large volume abdominal effusion, fluid therapy consisted of a combination of human serum albumin, canine albumin, synthetic colloids, and isotonic crystalloids. Cryopoor plasma (CPP) was used as a source of canine albumin and intravascular volume. On Day 4, food dye was given through a nasogastric tube due to suspicion of dehiscence of the anastomosis site. Dehiscence was confirmed during abdominal exploratory, and a second resection and anastomosis was performed. Abdominal partial closure with vacuum-assisted closure device was performed. Supportive care was continued with CPP CRI and imipenem CRI. Planned relaparotomy to change the vacuum-assisted closure device was performed 48 hours later, with abdominal closure 96 hours after anastomosis. The patient was discharged on Day 15. Recheck 12 months later was normal.
   New or Unique Information Provided - This case includes novel techniques such food dye via nasogastric tube to identify anastomosis dehiscence, use of CPP as a source of canine albumin, and antimicrobial CRI in a dog with septic peritonitis.
C1 [Ropski, Meaghan K.; Guillaumin, Julien; Monnig, Andrea A.; Townsend, Katy; McLoughlin, Mary A.] Ohio State Univ, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University
RP Guillaumin, J (通讯作者)，Ohio State Univ, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USA.
EM guillaumin.2@osu.edu
RI Guillaumin, Julien/G-5349-2012
OI Guillaumin, Julien/0000-0001-8622-4387; Monnig,
   Anea/0000-0002-0804-8581; Townsend, Katy/0000-0001-6405-0793
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   [No title captured]
NR 46
TC 11
Z9 13
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1479-3261
EI 1476-4431
J9 J VET EMERG CRIT CAR
JI J. Vet. Emerg. Crit. Care
PD MAY-JUN
PY 2017
VL 27
IS 3
BP 348
EP 356
DI 10.1111/vec.12583
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FA1KE
UT WOS:000405197400010
PM 28135411
DA 2026-07-24
ER
PT J
AU Lalezari, S
   Lee, CJ
   Borovikova, AA
   Banyard, DA
   Paydar, KZ
   Wirth, GA
   Widgerow, AD
AF Lalezari, Shadi
   Lee, Christine J.
   Borovikova, Anna A.
   Banyard, Derek A.
   Paydar, Keyianoosh Z.
   Wirth, Garrett A.
   Widgerow, Alan D.
TI Deconstructing negative pressure wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Exudate control; Macrodeformation; Microdeformation; Negative pressure
   wound therapy; Perfusion changes
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; PROSPECTIVE
   RANDOMIZED-TRIAL; SKIN-GRAFTS; BIOCHEMICAL MARKERS; POLYURETHANE-FOAM;
   DERMAL SUBSTITUTE; TISSUE PRESSURE; DIFFERENT SIZES; GROWTH-CONTROL
AB Since its introduction 20 years ago for the treatment of chronic wounds, negative pressure wound therapy use has expanded to a variety of other wound types. Various mechanisms of action for its efficacy in wound healing have been postulated, but no unifying theory exists. Proposed mechanisms include induction of perfusion changes, microdeformation, macrodeformation, exudate control and decreasing the bacterial load in the wound. We surmise that these different mechanisms have varying levels of dominance in each wound type. Specifically, negative pressure wound therapy is beneficial to acute open wounds because it induces perfusion changes and formation of granulation tissue. Post-surgical incisional wounds are positively affected by perfusion changes and exudate control. In the context of chronic wounds, negative pressure wound therapy removes harmful and corrosive substances within the wounds to affect healing. When skin grafts and dermal substitutes are used to close a wound, negative pressure wound therapy is effective in promoting granulation tissue formation, controlling exudate and decreasing the bacterial load in the wound. In this review, we elucidate some of the mechanisms behind the positive wound healing effects of negative pressure wound therapy, providing possible explanations for these effects in different wound types.
C1 [Lalezari, Shadi; Lee, Christine J.; Borovikova, Anna A.; Banyard, Derek A.; Paydar, Keyianoosh Z.; Wirth, Garrett A.; Widgerow, Alan D.] Univ Calif Irvine, Ctr Tissue Engn, Dept Plast Surg, Irvine, CA USA.
C3 University of California System; University of California Irvine
RP Widgerow, AD (通讯作者)，Ctr Tissue Engn, Plast Surg, 101 City Dr South,Bldg 55 Suite 108a, Orange, CA 92868 USA.
EM awidgero@uci.edu
RI Banyard, Derek/U-6633-2019; Widgerow, Alan/AAD-3883-2022
OI Banyard, Derek/0000-0002-8704-8327; Widgerow, Alan/0000-0002-5705-8073
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NR 66
TC 96
Z9 118
U1 1
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2017
VL 14
IS 4
BP 649
EP 657
DI 10.1111/iwj.12658
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FA2WQ
UT WOS:000405302600008
PM 27681204
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Cai, SS
   Gowda, AU
   Alexander, RH
   Silverman, RP
   Goldberg, NH
   Rasko, YM
AF Cai, Stephen S.
   Gowda, Arvind U.
   Alexander, Richard H.
   Silverman, Ronald P.
   Goldberg, Nelson H.
   Rasko, Yvonne M.
TI Use of negative pressure wound therapy on malignant wounds-a case report
   and review of literature
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE malignancy; malignant wound; negative pressure wound therapy;
   vacuum-assisted closure; wound closure
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; CLOSED INCISION
   MANAGEMENT; ANTIMICROBIAL SOLUTIONS; INSTILLATION; MECHANISMS; SURGERY;
   ULCERS
AB The presence of malignancy is considered a contraindication to the use of negative pressure wound therapy (NPWT) because of concerns that it may promote tumourigenesis and expedite metastasis. This notion is extrapolated from studies evaluating NPWT in normal tissues. Despite the absence of direct evidence, the use of this technology in malignant wounds is widely considered a contraindication. We present the case of a patient with treatment-resistant metastatic colon cancer, who developed a chronic abdominal wound with positive margins. A staged reconstruction using NPWT was performed and wound closure allowed the patient to meet eligibility criteria and enrol in a clinical trial for treatment of his oncological disease. Skin closure remained intact until the patient expired 6 months after the wound closure. This case, as well as others in the literature, demonstrated that the use of NPWT should not be considered an absolute contraindication in malignancy. Individualised approaches taking into account the patient's clinical scenario, the available evidence, as well as the risks and benefits of this technology are recommended.
C1 [Cai, Stephen S.; Gowda, Arvind U.; Silverman, Ronald P.; Goldberg, Nelson H.; Rasko, Yvonne M.] Univ Maryland, Med Ctr, Div Plast Surg, Baltimore, MD 21201 USA.
   [Alexander, Richard H.] Univ Maryland, Med Ctr, Div Surg Oncol, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore
RP Rasko, YM (通讯作者)，Univ Maryland, Med Ctr, Surg, 22 S Greene St, Baltimore, MD 21201 USA.
EM yrasko@smail.umaryland.edu
RI Silverman, Ronald/A-5155-2018
CR [Anonymous], 2014, J NATL CANC I
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NR 33
TC 26
Z9 31
U1 2
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2017
VL 14
IS 4
BP 661
EP 665
DI 10.1111/iwj.12665
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FA2WQ
UT WOS:000405302600010
PM 27696723
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Toume, S
   Gefen, A
   Weihs, D
AF Toume, Samer
   Gefen, Amit
   Weihs, Daphne
TI Low-level stretching accelerates cell migration into a gap
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cell migration; Gap closure; Mechanobiology; Sustained deformations;
   Wound healing
ID UNIAXIAL CYCLIC STRETCH; ENDOTHELIAL-CELLS; NEGATIVE-PRESSURE;
   MECHANOTRANSDUCTION; MORPHOGENESIS; THERAPY; FORCES
AB We observed that radially stretching cell monolayers at a low level (3%) increases the rate at which they migrate to close a gap formed by in vitro injury. Wound healing has been shown to accelerate in vivo when deformations are topically applied, for example, by negative pressure wound therapy. However, the direct effect of deformations on cell migration during gap closure is still unknown. Thus, we have evaluated the effect of radially applied, sustained (static) tensile strain on the kinematics of en mass cell migration. Monolayers of murine fibroblasts were cultured on stretchable, linear-elastic substrates that were subjected to different tensile strains, using a custom-designed three-dimensionally printed stretching apparatus. Immediately following stretching, the monolayer was wounded' at its centre, and cell migration during gap closure was monitored and quantitatively evaluated. We observed a significant increase in normalised migration rates and a reduction of gap closure time with 3% stretching, relative to unstretched controls or 6% stretch. Interestingly, the initial gap area was linearly correlated with the maximum migration rate, especially when stretching was applied. Therefore, small deformations applied to cell monolayers during gap closure enhance en mass cell migration associated with wound healing and can be used to fine-tune treatment protocols.
C1 [Toume, Samer; Weihs, Daphne] Technion Israel Inst Technol, Fac Biomed Engn, IL-3200003 Haifa, Israel.
   [Gefen, Amit] Tel Aviv Univ, Dept Biomed Engn, Fac Engn, Tel Aviv, Israel.
C3 Technion Israel Institute of Technology; Tel Aviv University
RP Weihs, D (通讯作者)，Technion Israel Inst Technol, Fac Biomed Engn, IL-3200003 Haifa, Israel.
EM daphnew@technion.ac.il
RI Weihs, Daphne/C-2860-2009; Gefen, Amit/M-4720-2015
OI Weihs, Daphne/0000-0002-9670-3418; Gefen, Amit/0000-0002-0223-7218
FU Israeli Ministry of Science and Technology Third Age Program
FX The work was partially supported by the Israeli Ministry of Science and
   Technology Third Age Program (DW and AG).
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NR 41
TC 19
Z9 21
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2017
VL 14
IS 4
BP 698
EP 703
DI 10.1111/iwj.12679
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FA2WQ
UT WOS:000405302600017
PM 27748039
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Juntermanns, B
   Cyrek, AE
   Bernheim, J
   Hoffmann, JN
AF Juntermanns, B.
   Cyrek, A. E.
   Bernheim, J.
   Hoffmann, J. N.
TI Management of lymphatic fistulas in the groin from a surgeon's
   perspective
SO CHIRURG
LA German
DT Article
ID VACUUM-ASSISTED-CLOSURE; ARTERIAL RECONSTRUCTION; DOXYCYCLINE TREATMENT;
   VASCULAR-SURGERY; VARICOSE-VEINS; THERAPY; COMPLICATIONS; LYMPHORRHEA;
   LYMPHADENECTOMY; RADIOTHERAPY
AB The postoperative occurrence of lymph fistulas in the groin is a complication that should be taken seriously. These fistulas cause an increase in morbidity and can support local and ascending infections. The treatment of this complication ranges from conservative procedures, such as compression dressings and bed rest to operative treatment with detection of the fistulas and ligation, negative pressure wound therapy (NPWT) or even muscle flaps. This review provides an overview of current therapeutic modalities.
   On the basis of a current literature search via PubMed, we identified possible treatment options, which are described in this article.
   The conservative treatment options presented still have an importance in treating groin fistulas. A selection of safe and effective interventional and operative treatments is presented.
   If there are indications for an interventional or operative treatment a variety of safe and effective therapies are available, which can significantly reduce the length of hospital stay. The option of treatment using a muscle flap is of value as a last resort in the treatment of infected vascular prosthesis in the groin of Szilagyi type III and should be used when necessary.
C1 [Juntermanns, B.; Cyrek, A. E.; Bernheim, J.] Univ Duisburg Essen, Univ Klinikum Essen, Klin Allgemein Viszeral & Transplantat Chirurg, Essen, Germany.
   [Hoffmann, J. N.] Elisabeth Krankenhaus Essen, Contilia Herz & Gefasszentrum, Klin Gefasschirurg & Phlebol, Essen, Germany.
C3 University of Duisburg Essen
RP Juntermanns, B (通讯作者)，Univ Duisburg Essen, Univ Klinikum Essen, Klin Allgemein Viszeral & Transplantat Chirurg, Essen, Germany.
EM benjamin.juntermanns@uk-essen.de
RI Cyrek, Anna/NAZ-7454-2025
OI Cyrek, Anna/0000-0001-5611-809X
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NR 30
TC 8
Z9 8
U1 0
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD JUL
PY 2017
VL 88
IS 7
BP 582
EP 586
DI 10.1007/s00104-017-0378-3
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FA2ZL
UT WOS:000405310600006
PM 28180975
DA 2026-07-24
ER
PT J
AU Dwivedi, MK
   Bhagat, AK
   Srivastava, RN
   Jain, A
   Baghel, K
   Raj, S
AF Dwivedi, Mukesh Kumar
   Bhagat, Amit Kumar
   Srivastava, Rajeshwar Nath
   Jain, Amita
   Baghel, Kavita
   Raj, Saloni
TI Expression of MMP-8 in Pressure Injuries in Spinal Cord Injury Patients
   Managed by Negative Pressure Wound Therapy or Conventional Wound Care
   A Randomized Controlled Trial
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Negative pressure wound therapy (NPWT); Pressure injury; Pressure ulcer;
   Spinal cord injury
ID VACUUM-ASSISTED CLOSURE; MATRIX METALLOPROTEINASES; ULCERS; PROTEASES;
   DEVICE; FLUID
AB PURPOSE: The purpose of this study was to assess the level of matrix metalloproteinase-8 (MMP-8) and wound-healing outcome measures (length, width, and depth, exudate amount, and tissue type) in pressure injuries (PIs) of spinal cord-injured patients treated with negative pressure wound therapy (NPWT) using a novel negative pressure device versus PI treated with wet to moist gauze (conventional wound care).
   DESIGN: Randomized controlled trial.
   SUBJECTS AND SETTING: Forty-four spinal cord-injured patients with stage 3 and 4 sacral PI participated in the study. The study setting was the Department of Orthopedic Surgery at King George's Medical University, in Lucknow, India.
   METHODS: Twenty two subjects were randomly allocated to undergo NPWT via a novel negative pressure device, and 22 participants received conventional wound dressing (wet to moist gauze dressings). Pressure injuries were treated for 9 weeks or until wound closure. Levels of MMP-8 were analyzed in the tissues of PIs at weeks 0, 3, 6, and 9 by enzyme-linked immunosorbent assay.
   RESULTS: Significantly lower levels of MMP-8 were observed in the NPWT group at week 6 and week 9. There were no significant changes in the length and width of PIs between the groups till week 3. Significant reduced length and width were observed in PIs of patients in the NPWT group at week 6 (P =.04) and week 9 (P =.001). Similarly, significant reduction in the depth of PIs was observed in the NPWT group at week 9 (P <.05). At the end of 9 week, levels of MMP-8 showed a positive correlation with reduction in the length, width, and depth of PIs in the NPWT group while in the conventional dressing group, negative correlation was observed in association with MMP-8 and the length, width, and depth of PIs. Exudate levels were significantly lower in the NPWT group compared with the conventional dressing group from week 3 (2.96 +/- 0.21 vs 2.62 +/- 0.49); this difference persisted through week 9 (1.35 +/- 0.75 vs 0.14 +/- 0.35). Conversion of slough into red granulation tissue was significantly higher in the NPWT group after week 6 (P =.001).
   CONCLUSION: Reduced levels of MMP-8 and an increased rate of healing were found in patients allocated to treatment with a novel negative pressure device as compared to wet to moist gauze conventional dressing. The novel NPWT device used in this study reduced exudate production and enhanced the rate of formation of red granulation tissue.
C1 [Dwivedi, Mukesh Kumar; Bhagat, Amit Kumar; Srivastava, Rajeshwar Nath; Baghel, Kavita] King Georges Med Univ, Dept Orthopaed Surg, Nabibullah Rd, Lucknow 226018, Uttar Pradesh, India.
   [Jain, Amita] King Georges Med Univ, Dept Microbiol, Lucknow, Uttar Pradesh, India.
   [Raj, Saloni] MS Ramaiah Med Coll, Bangalore, Karnataka, India.
C3 King George's Medical University; King George's Medical University
RP Srivastava, RN (通讯作者)，King Georges Med Univ, Dept Orthopaed Surg, Nabibullah Rd, Lucknow 226018, Uttar Pradesh, India.
EM drrnsrivastava@yahoo.com
RI jain, amita/ABA-9223-2020
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NR 26
TC 9
Z9 11
U1 1
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2017
VL 44
IS 4
BP 343
EP 349
DI 10.1097/WON.0000000000000333
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FA4JT
UT WOS:000405410300006
PM 28459717
DA 2026-07-24
ER
PT J
AU Li, ZQ
   Wu, WJ
   Liu, SJ
   Hao, YS
AF Li, Zhiqiang
   Wu, Wenjie
   Liu, Shujiang
   Hao, Yusheng
TI Effect of vacuum sealing drainage in dermatoplasty of large area of
   cutaneous defects
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Vacuum sealing drainage; Dermatoplasty; Cutaneous defects
ID PRESSURE WOUND THERAPY; SKIN; EXPERIENCE; DEEP
AB Objectives: To investigate the clinical effect of vacuum sealing drainage in dermatoplasty of large area of cutaneous defects in comparison to conventional treatment.
   Methods: 80 patients with large area of cutaneous defects were enrolled in this study, and they had received superficial thickness dermatoplasty. Then these patients were randomly divided into two groups based on follow-up treatments: vacuum sealing drainage (defined as group A, 40 cases) and conventional treatment (defined as group B, 40 cases). After operation, all the patients received similar hospital stay, antibiotics administration, swelling elimination and wound closure in these two groups.
   Results: No significant difference was observed in terms of the baseline characteristics between the two groups, including areas of cutaneous defects. Compared with conventional treatment group, the healing time of dermatoplasty was reduced significantly in vacuum sealing drainage group. Meanwhile, the rate of survival of dermatoplasty was better, and the rate of wound infection was lower in vacuum sealing drainage group than conventional treatment group.
   Conclusion: Vacuum sealing drainage is effective in treatment with large area of cutaneous defects combined with dermatoplasty, which had better clinical outcomes than conventional therapy. (C) 2017 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.
C1 [Li, Zhiqiang; Wu, Wenjie; Liu, Shujiang; Hao, Yusheng] Peoples Hosp Cangzhou, Dept Orthoped, Cangzhou 061000, Peoples R China.
RP Hao, YS (通讯作者)，Peoples Hosp Cangzhou, Dept Orthoped, Cangzhou 061000, Peoples R China.
EM haoyushenhb@163.com
FU cience and technology research and development plan of Cangzhou
   [131302084]
FX This research was supported by Science and technology research and
   development plan of Cangzhou (Grant No. 131302084).
CR Beltzer C, 2016, GMS INTERDISCIP PLAS, V5, DOI 10.3205/iprs000098
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NR 24
TC 23
Z9 32
U1 0
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD JUN
PY 2017
VL 42
BP 143
EP 146
DI 10.1016/j.ijsu.2017.04.059
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FA5AX
UT WOS:000405456100023
PM 28478317
DA 2026-07-24
ER
PT J
AU Ryan, E
AF Ryan, E.
TI The use of a micropore particle technology in the treatment of acute
   wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE dehisced surgical wounds; Acapsil; pressure ulcer; wound healing;
   micropore particle technology; acute wounds
AB Objective: A clinical audit was performed to evaluate whether Acapsil micropore particle technology (MPPT) powder could improve the management of acute wounds to heal by secondary intention.
   Method: Wounds, which could be characterised as sloughy, wet and probably infected, normally managed by debridement followed by negative pressure wound therapy (NPWT), were included in the evaluation. The MPPT powder was applied topically to the wound surface either once daily or on alternate days, with each wound receiving a total of two to five applications. Most patients had NPWT after the MPPT powder treatment had finished to assist healing.
   Results: The study included nine patients with dehisced surgical wounds and one with a category IV pressure ulcer (PU). The wounds were generally covered in slough, exudate and showing signs of local infection. The topical MPPT powder rapidly desloughed the wounds, controlled exudate levels, promoted granulation and was well tolerated. All wounds proceeded towards closure.
   Conclusion: Comparison of the present data with MPPT powder to standard treatment suggests that the speed of healing using MPPT was improved. Further examination is required to determine if this reduces dressing changes, nursing time, and financial cost.
C1 [Ryan, E.] Bristol Royal Infirm & Gen Hosp, Bristol Univ Hosp, Upper Maudlin St, Bristol, Avon, England.
C3 Bristol Royal Infirmary
RP Ryan, E (通讯作者)，Bristol Royal Infirm & Gen Hosp, Bristol Univ Hosp, Upper Maudlin St, Bristol, Avon, England.
EM Ebony.Ryan@UHBristol.nhs.uk
CR Bilyayeva OO, WNDS201705253 WOUNDS
   Menke NB, 2007, CLIN DERMATOL, V25, P19, DOI 10.1016/j.clindermatol.2006.12.005
   Phillips PL, 2010, WOUNDS UK, V1
   Willingsford Healthcare, 2016, AC HOW IT WORKS
NR 4
TC 7
Z9 8
U1 1
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2017
VL 26
IS 7
BP 404
EP 413
DI 10.12968/jowc.2017.26.7.404
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FA5IY
UT WOS:000405477800006
PM 28704154
DA 2026-07-24
ER
PT J
AU Willy, C
   Scheuermann-Poley, C
   Stichling, M
   von Stein, T
   Kramer, A
AF Willy, Christian
   Scheuermann-Poley, Catharina
   Stichling, Marcus
   von Stein, Thomas
   Kramer, Axel
TI Importance of wound irrigation solutions and fluids with antiseptic
   effects in therapy and prophylaxis. update 2017
SO UNFALLCHIRURG
LA German
DT Article
DE Antiseptics Instillation; Wound irrigation; Vacuum assistedwound
   closure; Surgical site infection; Prophylaxis
ID SURGICAL-SITE INFECTION; INSTILLATION; PREVENTION; EFFICACY; SURGERY
AB Introduction. Despite the use of modern antibiotics as well as complex perioperative, intraoperative and postoperative prophylactic measures, the rate of surgical site infections (SSI) could not be significantly reduced. The introduction of biocompatible antiseptic drugs with a high microbiocidal effect provided a successful alternative for infection prevention and therapy, particularly in a time of increasing occurrence of multi-drug resistant pathogens. Hence, questions about the risk-benefit ratio of antiseptic wound irrigation solutions, the prophylactic use of wound irrigation solutions for the reduction of SSI and the effect of negative pressure wound therapy combined with instillation (NPWTi) need to be answered.
   Method. Against the background of our own experiences with the use of antisepticwound irrigation solutions, a literature analysis (e.g. computer-supported MEDLINE, EMBASE and Cochrane database research as of April 2017) was performed.
   Results. Antiseptic fluids can be used both prophylactically and therapeutically, in acute and chronic, clean, contaminated and infected wounds to reduce the posttraumatic and postoperative wound infection rates. The antiseptic solutions that are commonly used in orthopedic and trauma surgery (e.g. PVP-iodine, octenidine, polyhexanide, sodium hypochlorite/hypochlorous acid and acetic acid), have in common that no development of resistance has so far been shown and that when the contraindications are taken into account, the antiseptic effect can develop without any clinically significant local and systemic side effects. As a rule the biocompatibility index is higher than 1 for the substancesmentioned. In addition, they show an antiseptic effect against biofilms and multidrug resistant pathogens. These antiseptic solutions can also be used for NPWTi with some limitations for octenidine.
   Conclusion. As the basic equipment in trauma surgery, a selection of three different antiseptic wound irrigation solutions for the reduction of the rates of posttraumatic and SSI can be recommended. The use of antiseptics should be reviewed on an ongoing basis in the daily clinical routine and particular attention should be paid to unwanted effects in the course of the healing process. After application of 7-14 days, the indications for continuing the use of the antiseptic solutions must be carefully re-evaluated.
C1 [Willy, Christian; Scheuermann-Poley, Catharina; Stichling, Marcus] Bundeswehrkrankenhaus Berlin, Klin Unfallchirurg Orthopadie Sept Rekonstrukt Ch, Forsch & Behandlungszentrum Sept Defektwunden, Scharnhorststr 13, D-10115 Berlin, Germany.
   [von Stein, Thomas] BG Unfallklin Murnau, Abt Sept & Rekonstrukt Chirurg, Murnau, Germany.
   [Kramer, Axel] Univ Med Greifswald, Inst Hyg & Umweltmed, Greifswald, Germany.
C3 Universitat Greifswald; Greifswald Medical School
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Berlin, Klin Unfallchirurg Orthopadie Sept Rekonstrukt Ch, Forsch & Behandlungszentrum Sept Defektwunden, Scharnhorststr 13, D-10115 Berlin, Germany.
EM christianwilly@bundeswehr.org
CR Abhyankar Suhas V, 2009, J Indian Med Assoc, V107, P904
   [Anonymous], 2016, Global Guidelines for the Prevention of Surgical Site Infection
   [Anonymous], ANTISEPTICS SURG
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NR 42
TC 15
Z9 20
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD JUL
PY 2017
VL 120
IS 7
BP 549
EP 560
DI 10.1007/s00113-017-0375-5
PG 12
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA FA5SD
UT WOS:000405503000003
PM 28643098
DA 2026-07-24
ER
PT J
AU Zhang, JS
   Ma, YQ
   Liang, XP
   Shi, B
AF Zhang, Jishen
   Ma, Yongqi
   Liang, Xiangping
   Shi, Bing
TI Applications of vacuum sealing drainage in treating seawater-immersed
   sulfur mustard injury
SO TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
LA English
DT Article
DE Seawater immersion; chemical weapon; sulfur mustard; intractable wound
ID NEGATIVE-PRESSURE THERAPY; MODEL; WOUNDS; VEGF
AB Vacuum sealing drainage has excellent therapeutic effects on the complex injuries. There is no relevant report on seawater-immersed sulfur mustard injury. The treatment effects were examined with miniature pigs. Injuries were performed on their back followed by vacuum sealing drainage at various pressures for nine days. Injured tissues were sampled up to 30 d after treatment and healing rates, levels of interleukin-6, tumor necrosis factor , and vascular endothelial growth factor were recorded. Vacuum sealing drainage enhances the healing of sulfur mustard wounds significantly, reduces the interleukin-6 and tumor necrosis factor levels in the wound, and increases the vascular endothelial growth factor expression. Pressure reduction by 180mmHg is the most suitable condition for vacuum treatment.
C1 [Zhang, Jishen; Shi, Bing] PLA, Dept Plast Surg, Hosp 309, Beijing, Peoples R China.
   [Ma, Yongqi; Liang, Xiangping] Dalian Xinhua Plast Hosp, Dept Plast Surg, Dalian, Liaoning Provin, Peoples R China.
RP Shi, B (通讯作者)，PLA, Dept Plast Surg, Hosp 309, Beijing, Peoples R China.
EM yy_309@sohu.com
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NR 20
TC 4
Z9 4
U1 0
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0277-2248
EI 1029-0486
J9 TOXICOL ENVIRON CHEM
JI Toxicol Environ. Chem.
PY 2017
VL 99
IS 5-6
BP 975
EP 986
DI 10.1080/02772248.2017.1338702
PG 12
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA FA6YT
UT WOS:000405591700021
DA 2026-07-24
ER
PT J
AU Loftus, TJ
   Bihorac, A
   Ozrazgat-Baslanti, T
   Jordan, JR
   Croft, CA
   Smith, RS
   Efron, PA
   Moore, FA
   Mohr, AM
   Brakenridge, SC
AF Loftus, Tyler J.
   Bihorac, Azra
   Ozrazgat-Baslanti, Tezcan
   Jordan, Janeen R.
   Croft, Chasen A.
   Smith, Robert Stephen
   Efron, Philip A.
   Moore, Frederick A.
   Mohr, Alicia M.
   Brakenridge, Scott C.
TI ACUTE KIDNEY INJURY FOLLOWING EXPLORATORY LAPAROTOMY AND TEMPORARY
   ABDOMINAL CLOSURE
SO SHOCK
LA English
DT Article
DE Acute care surgery; acute kidney injury; exploratory laparotomy;
   mortality; open abdomen; temporary abdominal closure
ID DAMAGE-CONTROL LAPAROTOMY; OPEN ABDOMEN; MANAGEMENT; TRAUMA; SEPSIS;
   COAGULOPATHY; THERAPY; SURGERY
AB Background: Acute kidney injury (AKI) following exploratory laparotomy and temporary abdominal closure (TAC) is poorly understood but clinically significant. We hypothesized that the prevalence of AKI would be highest 96 h following TAC, early hypoxemia would predict AKI, and that AKI would be an independent predictor of mortality. Methods: We performed a retrospective analysis of 251 acute care surgery patients managed with TAC by negative pressure wound therapy (NPWT). Kidney Disease: Improving Global Outcomes AKI stages were assessed on admission, initial TAC, and following TAC at 48 h, 96 h, and 7 d. Multivariate regression was performed to identify risk factors for AKI and inpatient mortality. Results: Fifty-seven percent of all patients developed AKI within 7 days of laparotomy (stage 1: 14%, 2: 21%, 3: 22%). The prevalence of AKI peaked 48 h following TAC, and stage correlated with inpatient mortality (stage 0: 7%, 1: 13%, 2: 19%, 3: 37%, P < 0.001). Overall mortality was 14%. Factors predictive of stage 2 or 3 AKI at 48 h included age >65 years (OR 2.6 [ 95% CI 1.4-4.9]), NPWT output >30 mL/h from first TAC to 48 h (2.0 [1.1-3.9]), and three parameters at initial laparotomy: mean arterial pressure <60 mm Hg (2.9 [1.0-8.5]), temperature <36 degrees C (2.1 [1.1-3.8]), and anion gap >21 mEq/L (1.9 [1.0-3.7]). AKI was an independent predictor of inpatient mortality (5.5 [2.5-11.8]). Conclusions: AKI is common following TAC, reaches greatest prevalence 48 h after initial laparotomy, and is associated with increased mortality. NPWT fluid loss is a risk factor for AKI that is unique to TAC patients.
C1 [Loftus, Tyler J.; Bihorac, Azra; Ozrazgat-Baslanti, Tezcan; Jordan, Janeen R.; Croft, Chasen A.; Smith, Robert Stephen; Efron, Philip A.; Moore, Frederick A.; Mohr, Alicia M.; Brakenridge, Scott C.] Univ Florida Hlth, Dept Surg, Gainesville, FL USA.
   [Loftus, Tyler J.; Bihorac, Azra; Ozrazgat-Baslanti, Tezcan; Jordan, Janeen R.; Croft, Chasen A.; Smith, Robert Stephen; Efron, Philip A.; Moore, Frederick A.; Mohr, Alicia M.; Brakenridge, Scott C.] Univ Florida Hlth, Sepsis & Crit Illness Res Ctr, Gainesville, FL USA.
   [Bihorac, Azra; Ozrazgat-Baslanti, Tezcan] Univ Florida Hlth, Dept Med, Gainesville, FL USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; State University
   System of Florida; University of Florida
RP Brakenridge, SC (通讯作者)，Univ Florida Hlth, 1600 SW Archer Rd Room M-602, Gainesville, FL 32610 USA.
EM Scott.Brakenridge@surgery.ufl.edu
RI ; Brakenridge, Scott/AAD-6691-2019; Mohr, Alicia/E-3016-2015; Loftus,
   Tyler/J-7761-2016; Bihorac, Azra/Q-6500-2016
OI Smith, Robert/0000-0002-0455-6415; Brakenridge,
   Scott/0000-0002-7327-3718; Mohr, Alicia/0000-0003-1732-1313; Loftus,
   Tyler/0000-0001-5354-443X; Bihorac, Azra/0000-0002-5745-2863
FU National Institute of General Medical Sciences (NIGMS) [R01
   GM105893-01A1, R01 GM113945-01, P50 GM111152-01]; NIGMS [T32 GM-08721];
   National Center for Advancing Translational Sciences of the National
   Institutes of Health [UL1TR001427]; National Center for Advancing
   Translational Sciences [UL1TR001427] Funding Source: NIH RePORTER;
   National Institute of General Medical Sciences [T32GM008721,
   R01GM110240, R01GM105893] Funding Source: NIH RePORTER; National
   Institute on Aging [P30AG028740] Funding Source: NIH RePORTER
FX The authors were supported in part by grants R01 GM105893-01A1 (AMM),
   R01 GM113945-01 (PAE), and P50 GM111152-01 (SCB, AB, TO-B, PAE, FAM,
   AMM) awarded by the National Institute of General Medical Sciences
   (NIGMS). TJL was supported by a post-graduate training grant (T32
   GM-08721) in burns, trauma, and perioperative injury by NIGMS. Research
   reported in this publication was supported by the National Center for
   Advancing Translational Sciences of the National Institutes of Health
   under Award Number UL1TR001427.
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NR 25
TC 6
Z9 6
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUL
PY 2017
VL 48
IS 1
BP 5
EP 10
DI 10.1097/SHK.0000000000000825
PG 6
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
   & Cardiology
GA FA7DM
UT WOS:000405605100002
PM 28009772
DA 2026-07-24
ER
PT J
AU Zhai, B
   Jin, X
   Wang, R
   Fang, TS
   Qu, J
   Wang, Y
   Liu, M
   Xu, LS
AF Zhai, Bo
   Jin, Xin
   Wang, Rui
   Fang, Taishi
   Qu, Jing
   Wang, Ying
   Liu, Ming
   Xu, Lishan
TI Applying negative pressure wound therapy in associating liver partition
   and portal vein ligation for staged hepatectomy: A case report
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE liver cancer; staged hepatectomy; associating liver partition and portal
   vein ligation for staged hepatectomy; negative pressure wound therapy;
   vacuum sealing drainage
AB Staged hepatectomy, particularly associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a recently developed advanced surgery for resecting liver tumors. However, large wound surfaces, incomplete drainage and high rates of mortality are vital limitations of ALPPS. The present case study describes a patient with liver cancer who underwent ALPPS surgery combined with negative pressure wound therapy. A 46-year-old male patient was hospitalized due to right upper abdominal pain. Computed tomography and magnetic resonance cholangiopancreatography scan results indicated gallbladder cancer, accompanied by multiple liver metastases. Resection of the right trisegment and partial resection of metastatic nodules in the left outer lobe were performed. Vacuum sealing drainage was pre-implanted at liver cross-sections with drainage tubes to drain the bile. The patient exhibited improved wound healing compared with conventional ALPPS.
C1 [Zhai, Bo; Jin, Xin; Fang, Taishi; Liu, Ming; Xu, Lishan] Harbin Med Univ, Affiliated Hosp 4, Dept Gen Surg, 37 Yiyuan St, Harbin 150001, Heilongjiang, Peoples R China.
   [Wang, Rui] Heilongjiang Prov Hosp, Dept Gastroenterol, Harbin 150036, Heilongjiang, Peoples R China.
   [Qu, Jing] Harbin Med Univ, Affiliated Hosp 4, Dept Orthoped, Harbin 150001, Heilongjiang, Peoples R China.
   [Wang, Ying] Harbin Med Univ, Affiliated Hosp 4, Dept Anesthesiol, Harbin 150001, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University
RP Xu, LS (通讯作者)，Harbin Med Univ, Affiliated Hosp 4, Dept Gen Surg, 37 Yiyuan St, Harbin 150001, Heilongjiang, Peoples R China.
EM Isxu6688@sina.com
RI jin, xin/KWU-0198-2024
FU National Natural Scientific Foundation of China [81401975]; Natural
   Science Foundation of Heilongjiang Province [D201250]; China
   Postdoctoral Science Foundation [2016M591564]; Heilongjiang Postdoctoral
   Fund [LBH-Z14219, LBH-Z16191]; Scientific Research Project of
   Heilongjiang Medical Science Institute [201502, 201710]; Heilongjiang
   Province Health Bureau [2014-399]
FX The present study was supported in part by the National Natural
   Scientific Foundation of China (grant 81401975), Natural Science
   Foundation of Heilongjiang Province (grant no. D201250), China
   Postdoctoral Science Foundation (grant no. 2016M591564), Heilongjiang
   Postdoctoral Fund (grant no. LBH-Z14219 and LBH-Z16191), Scientific
   Research Project of Heilongjiang Medical Science Institute (grant no.
   201502 and 201710), and Heilongjiang Province Health Bureau (grant no.
   2014-399).
CR Ananthakrishnan Ashwin, 2006, Semin Intervent Radiol, V23, P47, DOI 10.1055/s-2006-939841
   Banasiewicz T, 2011, VIDEOSURGERY MINIINV, V6, P155, DOI 10.5114/wiitm.2011.24694
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NR 10
TC 2
Z9 3
U1 0
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JUL
PY 2017
VL 14
IS 1
BP 642
EP 646
DI 10.3892/etm.2017.4566
PN B
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FA7RV
UT WOS:000405645500026
PM 28672979
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Crist, BD
   Oladeji, LO
   Khazzam, M
   Della Rocca, GJ
   Murtha, YM
   Stannard, JP
AF Crist, Brett D.
   Oladeji, Lasun O.
   Khazzam, Michael
   Della Rocca, Gregory J.
   Murtha, Yvonne M.
   Stannard, James P.
TI Role of acute negative pressure wound therapy over primarily closed
   surgical incisions in acetabular fracture ORIF: A prospective randomized
   trial
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Negative pressure wound therapy; Infection; Acetabular fracture;
   Surgical site infection; Incisional NPWT
ID ORTHOPEDIC-SURGERY; COMPLICATIONS; MANAGEMENT; CLOSURE; IMPACT
AB Background: Negative pressure wound therapy use over closed surgical incisions (iNPWT) has proven to be effective at reducing hematoma, wound drainage and infection in high-risk wounds. The purpose of this study was to determine if iNPWT decreased the risk of infection in patients undergoing open reduction internal fixation (ORIF) for acetabular fractures.
   Methods: 71 patients who underwent operative intervention for an acetabular fracture between March 2008 and September 2012 consented and prospectively randomized to iNPWT or a standard postoperative (dry gauze) dressing. The primary endpoint was deep infection, i.e. necessitating surgical debridement. Patients were followed until fracture union.
   Results: 33 patients were randomized to treatment with a standard gauze dressing and 33 patients were randomized to the iNPWT cohort. There were no statistically significant differences between the groups with respect to patient demographics, clinical, or surgery characteristics. Overall, seven patients (10.6%) were diagnosed with infections; two patients (6.1%) in the placebo group and 5 (15.2%) in the treatment group.
   Conclusions: In this randomized prospective trial, iNPWT did not decrease the incidence of deep infections when compared to gauze dressings in patients with acetabular fractures. Although not statistically significant, patients in the iNPWT cohort were 2.77 times more likely to develop a deep infection. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Crist, Brett D.; Oladeji, Lasun O.; Murtha, Yvonne M.; Stannard, James P.] Univ Missouri, Dept Orthopaed Surg, One Hosp Dr,N116, Columbia, MO 65211 USA.
   [Khazzam, Michael] Univ Texas Southwestern Med Ctr Dallas, Dept Orthopaed Surg, Dallas, TX 75390 USA.
   [Della Rocca, Gregory J.] Duke Univ, Dept Orthopaed Surg, Durham, NC USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Texas System; University of Texas Southwestern Medical
   Center; Duke University
RP Stannard, JP (通讯作者)，Univ Missouri, Dept Orthopaed Surg, One Hosp Dr,N116, Columbia, MO 65211 USA.
EM cristb@health.missouri.edu
RI Crist, Brett/AAC-7535-2019; Della Rocca, Gregory/AAM-5281-2021;
   /AAD-3102-2019
OI Stannard, James P/0000-0001-8467-6494; Oladeji,
   Lasun/0000-0002-6968-5568
CR Brem MH, 2014, INT WOUND J, V11, P3, DOI 10.1111/iwj.12252
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NR 27
TC 47
Z9 51
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JUL
PY 2017
VL 48
IS 7
BP 1518
EP 1521
DI 10.1016/j.injury.2017.04.055
PG 4
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA FB2TW
UT WOS:000405997100037
PM 28477992
DA 2026-07-24
ER
PT J
AU Glass, GE
   Murphy, GRF
   Nanchahal, J
AF Glass, Graeme E.
   Murphy, George R. F.
   Nanchahal, Jagdeep
TI Does negative-pressure wound therapy influence subjacent bacterial
   growth? A systematic review
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Negative-pressure wound therapy; NPWT; Bacterial bioburden;
   Non-fermentative gram-negative bacilli; Instillation therapy
ID VACUUM-ASSISTED CLOSURE; PSEUDOMONAS-AERUGINOSA; INSTILLATION;
   INFECTIONS; MANAGEMENT; BIOBURDEN; DRESSINGS
AB Background: Negative-pressure wound therapy is a ubiquitous wound management resource. The influence of NPWT on the bacterial bioburden of the subjacent wound remains unclear. We sought to examine the evidence.
   Datasources: MEDLINE, Embase, PubMed, the Cochrane Database of Systematic Reviews and the Cochrane Controlled Trials Register were searched for articles quantitatively evaluating bacterial load under NPWT.
   Results: Twenty-four studies met the inclusion criteria including 4 randomised controlled trials, 8 clinical series and 12 experimental studies. Twenty studies evaluated conventional NPWT, while 4 evaluated infiltration-based NPWT. While 8 studies using conventional NPWT failed to demonstrate an observable effect on bacterial load, 7 studies reported that NPWT was inherently bacteriostatic and 5 others reported species selectivity with suppression of non-fermentative gram-negative bacilli (NFGNB), including Pseudomonas spp. Simultaneously, there was some evidence of enhanced proliferation of gram-positive cocci where the niche was cleared of NFGNB. Two of the 4 studies using infiltration-based NPWT also reported selectively impaired proliferation of Pseudomonas spp.
   Conclusion: The assumption that NPWT suppresses bacterial proliferation is oversimplified. There is evidence that NPWT exhibits species selectivity, suppressing the proliferation of NFGNB. However, this may depopulate the niche for exploitation by gram-positive cocci. This, in turn, has implications for the use of NPWT where highly virulent strains of gram-positive cocci have been isolated and the duration of NPWT therapy and frequency of dressing changes. (C) 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Glass, Graeme E.; Nanchahal, Jagdeep] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Roosevelt Dr, Oxford OX3 7FY, England.
   [Glass, Graeme E.] Barts Hlth NHS Trust, Royal London Hosp, Whitechapel Rd, London, England.
   [Murphy, George R. F.] Univ Oxford, St Hughs Coll, Oxford, England.
C3 University of Oxford; Kennedy Institute for Rheumatology; Barts Health
   NHS Trust; Royal London Hospital; University of Oxford
RP Glass, GE (通讯作者)，Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Roosevelt Dr, Oxford OX3 7FY, England.
EM drgraemeglass@gmail.com; George.murphy@st-hugh's.ox.ac.uk;
   jagdeep.nanchahal@kennedy.ox.ac.uk
RI ; Glass, Graeme/I-7011-2019
OI Nanchahal, Jagdeep/0000-0002-9579-9411; 
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NR 45
TC 25
Z9 35
U1 0
U2 13
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2017
VL 70
IS 8
BP 1028
EP 1037
DI 10.1016/j.bjps.2017.05.027
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FB2YP
UT WOS:000406009900007
PM 28602266
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Giudicelli, G
   Rossetti, A
   Scarpa, C
   Buchs, NC
   Hompes, R
   Guy, RJ
   Ukegjini, K
   Morel, P
   Ris, F
   Adamina, M
AF Giudicelli, Guillaume
   Rossetti, A.
   Scarpa, C.
   Buchs, N. C.
   Hompes, R.
   Guy, R. J.
   Ukegjini, K.
   Morel, P.
   Ris, F.
   Adamina, M.
TI Prognostic Factors for Enteroatmospheric Fistula in Open Abdomen Treated
   with Negative Pressure Wound Therapy: a Multicentre Experience
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article; Proceedings Paper
CT 103rd Annual Congress of the Swiss-Society-of-Surgery
CY JUN 01-03, 2016
CL Bern, SWITZERLAND
SP Swiss Soc Surg
DE Open abdomen; Negative pressure wound therapy; Enteroatmospheric fistula
ID ABDOMINAL COMPARTMENT SYNDROME; UPDATED CONSENSUS DEFINITIONS;
   CLINICAL-PRACTICE GUIDELINES; INTRAABDOMINAL HYPERTENSION; MANAGEMENT;
   CLASSIFICATION; SOCIETY; CLOSURE; COMPLICATIONS; LAPAROTOMY
AB Background Reductions in mortality were reported with negative pressure wound therapy for laparostomy. However, some authors have voiced concern over an increased risk of enteroatmospheric fistulae. In this retrospective study, we hypothesized that surgical and metabolic derangements could increase the incidence of enteroatmospheric fistulae. We aimed to assess our experience and report long-term outcomes.
   Methods A multicentre review of all patients with a laparostomy managed with negative pressure wound therapy between 2005 and 2015 was undertaken. Features associated with enteroatmospheric fistulae were included in multivariate logistic regression.
   Results Fifty-seven patients were treated according to uniform protocol. Fourteen per cent (8/57) presented enteroatmospheric fistulae. Mesenteric ischaemia and preoperative arterial serum lactate > 3.5 mmol/L were associated with a significantly increased risk of enteroatmospheric fistulae. Preoperative arterial serum lactate > 3.5 mmol/L was an independent predictor of enteroatmospheric fistulae with an odds ratio of 12.41 (95% CI 1.54-99.99). All mesenteric ischaemia patients with anastomosis (5/15) presented enteroatmospheric fistulae. In-hospital mortality was 26.3% (15/57). One-year mortality was 33.3% (19/57). Incisional hernia rate was 5.2% (2/38) after 14.2 (2.4-56.3) months of follow-up.
   Discussion Mesenteric ischaemia increases the risk of enteroatmospheric fistulae. Anastomosis should only be created in revascularized patients. When mesenteric vascularization is not restored, diversion is advised.
C1 [Giudicelli, Guillaume; Scarpa, C.; Buchs, N. C.; Morel, P.; Ris, F.] Geneva Univ Hosp, Div Visceral Surg, Dept Surg, Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Rossetti, A.; Ukegjini, K.] Cantonal Hosp Sankt Gallen, Dept Visceral Surg, St Gallen, Switzerland.
   [Buchs, N. C.; Hompes, R.; Guy, R. J.] Oxford Univ Hosp, Churchill Hosp, Dept Colorectal Surg, Oxford, England.
   [Adamina, M.] Kantonsspital Winterthur, Div Visceral & Thorac Surg, Dept Surg, Winterthur, Switzerland.
   [Adamina, M.] Univ Basel, Basel, Switzerland.
C3 Kantonsspital St. Gallen; University of Oxford; University of Basel
RP Giudicelli, G (通讯作者)，Geneva Univ Hosp, Div Visceral Surg, Dept Surg, Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM guillaume.giudicelli@hcuge.ch
RI Adamina, Michel/J-8034-2019; Giudicelli, Guillaume/AAY-3512-2021; Ris,
   Frederic/H-7030-2019; Hompes, Roel/AAN-6249-2020
OI Adamina, Michel/0000-0002-5464-6953; Buchs, Nicolas/0000-0001-9255-3929;
   Giudicelli, Guillaume/0000-0002-0213-9335; Ris,
   Frederic/0000-0001-7421-6101; Hompes, Roel/0000-0001-6094-8950
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
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   Marinis A, 2013, SCAND J SURG, V102, P61, DOI 10.1177/1457496913482252
   Roberts DJ, 2012, J TRAUMA ACUTE CARE, V73, P629, DOI 10.1097/TA.0b013e31825c130e
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NR 28
TC 17
Z9 27
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD AUG
PY 2017
VL 21
IS 8
BP 1328
EP 1334
DI 10.1007/s11605-017-3453-7
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology; Surgery
GA FB3EV
UT WOS:000406026400017
PM 28536807
DA 2026-07-24
ER
PT J
AU de Vries, FEE
   Atema, JJ
   Lapid, O
   Obdeijn, MC
   Boermeester, MA
AF de Vries, F. E. E.
   Atema, J. J.
   Lapid, O.
   Obdeijn, M. C.
   Boermeester, M. A.
TI Closed incision prophylactic negative pressure wound therapy in patients
   undergoing major complex abdominal wall repair
SO HERNIA
LA English
DT Article
DE Complex abdominal wall repair; Prophylactic negative pressure
ID ACELLULAR DERMAL MATRIX; VENTRAL HERNIA REPAIRS; STAGE REPAIR;
   RECONSTRUCTION; DEFECTS; EXPERIENCE; MANAGEMENT; COST; MESH
AB Purpose To evaluate if incisional prophylactic negative pressure wound therapy (pNPWT) reduces wound infections and other wound complications in high-risk patients undergoing major complex ventral abdominal wall repair.
   Methods Retrospective before-after comparison nested in a consecutive series of patients undergoing elective major complex abdominal wall repair. Starting January 2014, pNPWT was applied on the closed incisional wound for a minimum of 5 days. To minimize selection bias, we compared two periods of 14 months before and after January 2014. Wound infections according to the Centre for Disease Control Surgical Site Infection classification as well as other wound complications were recorded.
   Results Thirty-two patients were included in the pNPWT group and 34 in the control group. The study group involved clean-contaminated and contaminated operations due to enterocutaneous fistula, enterostomies or infected mesh. Median duration of pNPWT was 5 days (IQR 5-7). Overall wound infection rate was 35%. pNPWT was associated with a significant decrease in postoperative wound infection rate (24 versus 51%; p = 0.029, OR 0.30 (95% CI 0.10-0.90)). Incisional wound infection rates dropped from 48 to 7% (p < 0.01, OR 0.08 (95% CI 0.16-0.39), whereas the number of subcutaneous abscesses was comparable in both groups. Moreover, less interventions were needed in the pNPWT group (p < 0.001).
   Conclusions Closed incision pNPWT seems a promising solution to reduce the incidence of wound infections in complex abdominal wall surgery. Randomized controlled trials are needed to estimate more precisely the value and cost-effectiveness of pNPWT in this high-risk setting.
C1 [de Vries, F. E. E.; Atema, J. J.; Boermeester, M. A.] Acad Med Ctr, Dept Surg, POB 22660, NL-1100 DD Amsterdam, Netherlands.
   [Atema, J. J.] Onze Lieve Vrouw Hosp, Dept Surg, Amsterdam, Netherlands.
   [Lapid, O.; Obdeijn, M. C.] Acad Med Ctr, Dept Plast & Reconstruct Surg, Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Onze Lieve
   Vrouwe Gasthuis Hospital; University of Amsterdam; Academic Medical
   Center Amsterdam
RP de Vries, FEE (通讯作者)，Acad Med Ctr, Dept Surg, POB 22660, NL-1100 DD Amsterdam, Netherlands.
EM f.e.devries@amc.uva.nl
RI Lapid, Oren/S-6331-2019
OI Lapid, Oren/0000-0001-8921-9866; Boermeester, Marja/0000-0003-3890-8105
CR Allegranzi Benedetta, 2016, Lancet Infect Dis, V16, pe288, DOI 10.1016/S1473-3099(16)30402-9
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   [Anonymous], LANCET INFECT DIS
   [Anonymous], ANN PLAST SURG
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NR 27
TC 42
Z9 44
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD AUG
PY 2017
VL 21
IS 4
BP 583
EP 589
DI 10.1007/s10029-017-1620-0
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FB3IQ
UT WOS:000406036600013
PM 28534258
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Waugh, L
   D'Agostino, J
   Cole, GA
   Hahn, A
   Day, JD
AF Waugh, Lynnette
   D'Agostino, Jennifer
   Cole, Gretchen A.
   Hahn, Alicia
   Day, Jonathan D.
TI MANAGEMENT OF PODODERMATITIS WITH AN ORTHOTIC BOOT IN A SOUTHERN ISABELA
   GIANT TORTOISE (CHELONOIDIS VICINA)
SO JOURNAL OF ZOO AND WILDLIFE MEDICINE
LA English
DT Article
DE Chelonoidis vicina; orthotic; boot; pododermatitis; total contact
   casting; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; WOUNDS
AB A 62-yr-old male Southern Isabela giant tortoise (Chelonoidis vicina) had a 1-yr history of chronic, reoccurring pododermatitis on the palmar surface of the left forelimb. Aggressive wound management was instituted and included surgical debridement, vacuum-assisted closure, and orthotic boot support during healing. A custom fabricated, carbon fiber clamshell Charcot Restraint Orthotic Walker walking boot was utilized to reduce focal pressure over the wound during weight bearing and promote a more normal gait. Distal padding was used to distribute pressure on the palmar surface of the left forelimb, with a focal depression in the padding preventing pressure directly over the wound. The design and trim lines were adjusted to allow shoulder and elbow motion without impingement. The clamshell design allowed relatively easy removal for wound inspection and dressing changes. The wound ultimately resolved after 9 wk of management with the orthotic boot, with no reoccurrence over the next 3 yr.
C1 [Waugh, Lynnette; D'Agostino, Jennifer; Cole, Gretchen A.; Hahn, Alicia] Oklahoma City Zoo, 2101 NE 50th St, Oklahoma City, OK 73111 USA.
   [Day, Jonathan D.] Univ Oklahoma, Coll Med, Hlth Sci Ctr, 1200 Childrens Ave, Oklahoma City, OK 73104 USA.
   [Hahn, Alicia] Pittsburgh Zoo & PPG Aquarium, 7340 Butler St, Pittsburgh, PA 15206 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center
RP D'Agostino, J (通讯作者)，Oklahoma City Zoo, 2101 NE 50th St, Oklahoma City, OK 73111 USA.
EM jdagostino@okczoo.org
OI D'Agostino, Jennifer/0009-0001-3542-8416
CR Adkesson MJ, 2007, JAVMA-J AM VET MED A, V231, P1249, DOI 10.2460/javma.231.8.1249
   Armstrong David G, 2004, Int J Low Extrem Wounds, V3, P12, DOI 10.1177/1534734604263291
   Bezjian M, 2014, J ZOO WILDLIFE MED, V45, P428, DOI 10.1638/2013-0178R.1
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
   Hawkins MG, 2012, FERRETS RABBITS RODE, P305
   Hebs L, 2012, FERRETS RABBITS RODE, P235
   Lafortune M, 2004, J HERPETOL MED SURG, V15, P4
   Schmidt Robert E., 2006, P395
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NR 10
TC 0
Z9 1
U1 0
U2 2
PU AMER ASSOC ZOO VETERINARIANS
PI YULEE
PA 581705 WHITE OAK ROAD, YULEE, FL 32097 USA
SN 1042-7260
EI 1937-2825
J9 J ZOO WILDLIFE MED
JI J. Zoo Wildl. Med.
PD JUN
PY 2017
VL 48
IS 2
BP 594
EP 597
DI 10.1638/2016-0185.1
PG 4
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FB8IM
UT WOS:000406382700050
PM 28749259
DA 2026-07-24
ER
PT J
AU Yang, SL
   Zhu, LY
   Han, R
   Sun, LL
   Dou, JT
AF Yang, Shao Ling
   Zhu, Lv Yun
   Han, Rui
   Sun, Lei Lei
   Dou, Jing Tao
TI Effect of Negative Pressure Wound Therapy on Cellular Fibronectin and
   Transforming Growth Factor-β1 Expression in Diabetic Foot Wounds
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE negative-pressure wound therapy; cellular fibronectin; transforming
   growth factor-beta 1; diabetic foot wounds
ID VACUUM-ASSISTED CLOSURE; GROWTH-FACTORS; ULCERS; PATHOGENESIS;
   MULTICENTER; ULCERATION; AMPUTATION; MORTALITY; FIBROSIS
AB Background: Chronic diabetic foot wounds are a leading cause of amputation, morbidity, and hospitalization for patients with diabetes. Negative-pressure wound therapy (NPWT) can putatively facilitate wound healing, but the underlying mechanisms remain unclear. Cellular fibronectin (cFN) and transforming growth factor-beta 1 (TGF-beta 1) play an important role in wound healing. This prospective randomized controlled trial evaluated the effects of NPWT on the production of cFN and the expression of TGF-beta 1 in diabetic foot wounds of patients.
   Methods: From January 2012 to January 2015, 40 patients with diabetic foot wounds were randomly and equally apportioned to receive either NPWT or advanced moist wound therapy (control) for 7 days. Granulation tissue was harvested before and after treatment. Immunohistochemistry and Western blot were performed to evaluate protein levels of cFN and TGF-beta 1, and real-time polymerase chain reaction (PCR) to measure corresponding mRNA expressions.
   Results: NPWT facilitated the expression of cFN and TGF-beta 1 in diabetic foot wounds. Immunohistochemical analysis revealed higher levels of cFN and TGF-beta 1 in the NPWT group than in the control group. Western blot and real-time PCR analysis further showed that protein and mRNA levels of cFN or TGF-beta 1 were higher in the NPWT group than that in the control group (P < .01, both).
   Conclusion: Our results showed that NPWT facilitated the production of cFN and the expression of TGF-beta 1 in granulation tissue in diabetic foot ulcers.
C1 [Yang, Shao Ling; Dou, Jing Tao] Chinese PLA Gen Hosp Hosp, Dept Endocrinol, Hosp 301, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [Yang, Shao Ling; Zhu, Lv Yun] Bethune Int Peace Hosp PLA, Dept Endocrinol, Shijiazhuang, Hebei, Peoples R China.
   [Han, Rui] Hebei Med Univ, Dept Neurol, Affiliated Hosp 1, Shijiazhuang, Hebei, Peoples R China.
   [Sun, Lei Lei] Armed Police Hosp Shandong, Dept Endocrinol, Jinan, Shandong, Peoples R China.
C3 Hebei Medical University
RP Dou, JT (通讯作者)，Chinese PLA Gen Hosp Hosp, Dept Endocrinol, Hosp 301, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM doujingtao301@126.com
RI lvyun, zhu/Z-4736-2019
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NR 45
TC 23
Z9 35
U1 0
U2 23
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD AUG
PY 2017
VL 38
IS 8
BP 893
EP 900
DI 10.1177/1071100717704940
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA FC3AK
UT WOS:000406710400010
PM 28459181
DA 2026-07-24
ER
PT J
AU Go, ML
   Or, M
   Van Goethem, B
   Kitshoff, A
   Abma, E
   de Rooster, H
AF Go, M. L.
   Or, M.
   Van Goethem, B.
   Kitshoff, A.
   Abma, E.
   de Rooster, H.
TI Negative pressure wound therapy: the past and the future
SO VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
LA English
DT Review
ID VACUUM-ASSISTED-CLOSURE; SUBATMOSPHERIC PRESSURE; NECROTIZING FASCIITIS;
   SEPTIC PERITONITIS; DISTAL EXTREMITY; SKIN-GRAFTS; MANAGEMENT;
   RECONSTRUCTION; OSTEOMYELITIS; INSTILLATION
AB Negative pressure wound therapy (NPWT) involves the application of negative pressure on a wound bed for its positive effects on wound healing. Indications for NPWT concern various types of wounds, skin grafts and flaps, partial-thickness burns, open abdomen management and closed incisions.
   Negative pressure wound therapy has been used for centuries in human medicine. Its first use dates back to the Roman era (around 27 BCE) when human generated pressures were used. Later, European and Russian physicians developed various advanced methods and systems to apply negative pressure on wounds or other injuries. The on-going positive findings in human medicine triggered researchers in veterinary medicine to apply this technique on animal patients.
   However, much still has to be investigated regarding NPWT, especially in veterinary medicine, as there are many factors playing a role in the mechanisms of this treatment. New methods and techniques are continuously being developed and the existing studies show great potential for NPWT.
C1 [Go, M. L.; Or, M.; Van Goethem, B.; Kitshoff, A.; Abma, E.; de Rooster, H.] Univ Ghent, Fac Vet Med, Small Anim Dept, Salisburylaan 133, B-9820 Merelbeke, Belgium.
C3 Ghent University
RP Go, ML (通讯作者)，Univ Ghent, Fac Vet Med, Small Anim Dept, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM mei.go@ugent.be
RI de Rooster, Hilde/AAX-9497-2020; Kitshoff, Adriaan/AFS-4979-2022; Van
   Goethem, Bart/AAM-7175-2020
OI de Rooster, Hilde/0000-0001-8087-256X; Kitshoff,
   Adriaan/0000-0001-9657-740X; 
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NR 82
TC 1
Z9 2
U1 1
U2 17
PU UNIV GHENT
PI GHENT
PA FACULTY VETERINARY MEDICINE, B-9000 GHENT, BELGIUM
SN 0303-9021
J9 VLAAMS DIERGEN TIJDS
JI Vlaams Diergeneeskd. Tijdschr.
PD MAY-JUN
PY 2017
VL 86
IS 3
BP 127
EP 135
DI 10.21825/vdt.v86i3.16282
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FC3JZ
UT WOS:000406736200001
OA Bronze
DA 2026-07-24
ER
PT J
AU Montori, G
   Allievi, N
   Coccolini, F
   Solaini, L
   Campanati, L
   Ceresoli, M
   Fugazzola, P
   Manfredi, R
   Magnone, S
   Tomasoni, M
   Ansaloni, L
AF Montori, Giulia
   Allievi, Niccolo
   Coccolini, Federico
   Solaini, Leonardo
   Campanati, Luca
   Ceresoli, Marco
   Fugazzola, Paola
   Manfredi, Roberto
   Magnone, Stefano
   Tomasoni, Matteo
   Ansaloni, Luca
TI Negative Pressure Wound Therapy versus modified Barker Vacuum Pack as
   temporary abdominal closure technique for Open Abdomen management: a
   four-year experience
SO BMC SURGERY
LA English
DT Article
DE Temporary abdominal closure; Negative Pressure Wound Therapy; Barker
   Vacuum Pack; Open Abdomen; Trauma; Emergency surgery
AB Background: We reviewed our experience with patients presenting with trauma and peritonitis who underwent an open abdomen (OA) procedure, and compared outcomes between Negative Pressure Wound Therapy (NPWT) and a modified Barker Vacuum Pack (mBVP) technique.
   Methods: In this descriptive study, we retrospectively analyzed data regarding all patients who underwent OA for intra-abdominal sepsis or abdominal trauma at our Centre from January 2012 to December 2015. Demographic data, co-morbidities, indications to surgery, intra-operative details and Bjorck classification grade were considered. Outcomes included were: time to closure in days, fascial closure rates, ICU and hospital stay, in-hospital and overall mortality, and entero-atmospheric fistula rate.
   Results: A total of 83 cases were considered. Mean closure time was 6 days versus 6.5 days (p = 0.71) in NPWT and mBVP groups, respectively; the fascial closure rate was 75.4% versus 93.8% (p = 0.10). At multivariate analysis, in-hospital and overall mortality were significantly higher within the mBVP, as compared to NPWT (OR 3.8, 95% CI 1.1 to 13.1, p = 0.02 -OR 4.2, 95% CI 1.2 to 14.1, p = 0.01). Entero-atmospheric fistula rate was 2.6% in the two groups.
   Conclusions: NPWT as a temporary abdominal closure technique, as compared to mBVP, appears to be associated with better outcomes in terms of mortality.
C1 [Montori, Giulia; Allievi, Niccolo; Coccolini, Federico; Solaini, Leonardo; Campanati, Luca; Ceresoli, Marco; Fugazzola, Paola; Manfredi, Roberto; Magnone, Stefano; Tomasoni, Matteo; Ansaloni, Luca] Papa Giovanni XXIII Hosp, Unit Gen Surg, Pzza OMS 1, I-24127 Bergamo, Italy.
C3 ASST Papa Giovanni XXIII
RP Allievi, N (通讯作者)，Papa Giovanni XXIII Hosp, Unit Gen Surg, Pzza OMS 1, I-24127 Bergamo, Italy.
EM niccolo.allievi@gmail.com
RI Ansaloni, Luca/AAJ-6507-2020; Montori, Giulia/ABF-9661-2020; Coccolini,
   Federico/AAJ-6507-2020; Ceresoli, Marco/GMW-5356-2022; Fugazzola,
   Paola/AAH-4680-2019; Allievi, Niccolò/HPC-9638-2023; Magnone,
   Stefano/R-6719-2016; Tomasoni, Matteo/AAC-3732-2022; Ansaloni,
   Luca/AAP-9134-2020
OI Ansaloni, Luca/0000-0001-6427-0307; Montori, Giulia/0000-0002-7649-2174;
   Solaini, Leonardo/0000-0002-5031-9285; Coccolini,
   Federico/0000-0001-6364-4186; Ceresoli, Marco/0000-0001-7935-3842;
   Fugazzola, Paola/0000-0002-6227-9276; Magnone,
   Stefano/0000-0002-8001-3754; Ansaloni, Luca/0000-0001-6427-0307
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NR 20
TC 21
Z9 27
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD JUL 21
PY 2017
VL 17
AR 86
DI 10.1186/s12893-017-0281-3
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FC4CW
UT WOS:000406787200001
PM 28732537
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chen, DZ
   Zhao, Y
   Li, ZH
   Shou, KQ
   Zheng, X
   Li, PC
   Qi, BW
   Yu, AX
AF Chen, Dezhi
   Zhao, Yong
   Li, Zonghuan
   Shou, Kangquan
   Zheng, Xun
   Li, Pengcheng
   Qi, Baiwen
   Yu, Aixi
TI Circulating fibrocyte mobilization in negative pressure wound therapy
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE diabetic wound; circulating fibrocyte; negative pressure wound therapy
ID PERIPHERAL-BLOOD FIBROCYTES; ANGIOGENESIS IN-VIVO;
   MYOCARDIAL-INFARCTION; PROGENITOR CELLS; RECEPTOR CXCR4; BONE-MARROW;
   AMD3100; MIGRATION; FIBROSIS; SKIN
AB Non-healing diabetic wounds are difficult to treat. They also create heavy financial burdens for both patients and society. Negative pressure wound therapy (NPWT) has been adopted to treat intractable wounds and has proved to be effective. However, the mechanisms that underlie the effects of this treatment are not entirely understood. Circulating fibrocytes are unique haematopoietic-derived stem cells that have been reported to play a pivotal role in wound healing. Here, we have investigated the effect of NPWT on fibrocyte mobilization and the role of fibrocyte mobilization in the healing of diabetic wounds during NPWT. We show that the NPWT group exhibited 2.6-fold to 12.1-fold greater numbers of tail vein-injected PKH-26-labelled fibrocytes in the diabetic wound sites compared with the control group. We also demonstrate that the full-thickness skin wounds treated with NPWT exhibit significantly reduced mRNA and protein expression, blood vessel density and proliferating cells when exogenous fibrocyte mobilization is inhibited. We speculate that systemic mobilization of fibrocytes during NPWT may be a mechanism for healing intractable wounds in a diabetic rat model experiment and that enhancement of cell mobilization may represent a potential treatment idea for intractable wound healing across all fields of surgery.
C1 [Chen, Dezhi; Zhao, Yong; Li, Zonghuan; Shou, Kangquan; Zheng, Xun; Li, Pengcheng; Qi, Baiwen; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan, Hubei, Peoples R China.
C3 Wuhan University
RP Qi, BW; Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan, Hubei, Peoples R China.
EM qbw2004@sina.com; yuaixi@whu.edu.cn
RI /E-6566-2018; Zheng, Xun/JEP-2802-2023; Li, Pengcheng/ABF-5376-2021
FU National Natural Science Foundation of China [81572163]; Hubei National
   Natural Science Fund projects [2014CFB751]; Wuhan Huanghe Elite Program
FX This study was supported by the National Natural Science Foundation of
   China (Grant No. 81572163) and Hubei National Natural Science Fund
   projects (Grant No. 2014CFB751), and Wuhan Huanghe Elite Program. The
   authors would like to acknowledge the Wuhan VSD Medical Science &
   Technology, Co., Ltd. (Wuhan, China) for supplying the vacuum material.
   No conflict of interest exits in the manuscript.
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NR 44
TC 13
Z9 15
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD AUG
PY 2017
VL 21
IS 8
BP 1513
EP 1522
DI 10.1111/jcmm.13080
PG 10
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA FC4TG
UT WOS:000406833000008
PM 28211211
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, Z
   Bai, M
   Long, X
   Zhao, R
   Wang, XJ
AF Wang, Zhi
   Bai, Ming
   Long, Xiao
   Zhao, Ru
   Wang, Xiaojun
TI Negative Pressure Wound Therapy for Patients With Complex Abdominal
   Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE intra-abdominal hypertension; intra-abdominal infections; negative
   pressure wound therapy; abdominal wound closure; vacuum-assisted closure
ID OPEN ABDOMEN; INTRAABDOMINAL HYPERTENSION; SECONDARY PERITONITIS;
   COMPARTMENT SYNDROME; CLOSURE; PANCREATITIS; MANAGEMENT; OUTCOMES;
   SYSTEM
AB The combination of open abdominal wounds and intra-abdominal infections is challenging to treat and often results in critical illness associated with high mortality. Objective. The aim of this study is to evaluate the feasibility of using negative pressure wound therapy (NPWT) to manage complex abdominal wounds and summarize relevant treatment experiences. Materials and Methods. A retrospective analysis of records from April 2012 to May 2015 identified 13 hospitalized patients with open abdominal wounds complicated by intra-abdominal infections. Patients received Systemic antibiotics. Negative pressure wound therapy was applied at the bedside if prior debridement or decompression and drainage via laparotomy did not yield positive results or if the patient could not undergo surgery. Results. Of the 13 patients who were included in the study, 10 achieved wound closure (range, 19-52 days; median, 26 days). Among the 3 patients who did not achieve closure, 1 requested transfer to a hospital in his hometown, 1 developed an intestinal fistula that required surgery, and, 1 died of a digestive tract hemorrhage unrelated to NPWT. Conclusions. By providing sufficient drainage, NPWT effectively removed wound fluid and infectious material. The reduced edema helped lower intra-abdominal pressure, reduce the risk of abdominal compartment syndrome and infection, and improve patient prognosis.
C1 [Wang, Zhi; Bai, Ming; Long, Xiao; Zhao, Ru; Wang, Xiaojun] Beijing Union Med Coll Hosp, Plast & Aesthet Surg Ctr, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital
RP Wang, XJ (通讯作者)，Beijing Union Med Coll Hosp, Peking Union Med Coll, Plast & Aesthet Surg Ctr, 1 Shuaifuyuan, Beijing 100730, Peoples R China.; Wang, XJ (通讯作者)，Chinese Acad Med Sci, 1 Shuaifuyuan, Beijing 100730, Peoples R China.
EM xjwang100@hotmail.com
RI 龙, 笑/GPW-6382-2022; wang, xiaojun/NFT-0476-2025
CR Batacchi S, 2009, CRIT CARE, V13, DOI 10.1186/cc8193
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NR 27
TC 2
Z9 2
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2017
VL 29
IS 7
BP 202
EP 208
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FD1OL
UT WOS:000407306500004
PM 28759427
DA 2026-07-24
ER
PT J
AU Florczyk, A
   Rosser, J
AF Florczyk, Agnieszka
   Rosser, Julie
TI Negative-Pressure Wound Therapy as Management of a Chronic Distal Limb
   Wound in the Horse
SO JOURNAL OF EQUINE VETERINARY SCIENCE
LA English
DT Article
DE NPWT; VAC; Exuberant granulation tissue
AB Wound healing in distal limb wounds with tissue loss in horses may be an expensive and long process due to prolonged inflammatory phase. Negative pressure wound therapy (NPWT) (also known as vacuum-assisted closure) is well established method of wound therapy in human plastic and reconstructive surgery for many years. It consists of a leak free bandage and a pump that applies subatmospheric pressure to the wound area. This report describes the successful use of the NPWT intended for the suppression of exuberant granulation tissue development of the wound on distal limb in a horse. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Florczyk, Agnieszka; Rosser, Julie] Univ Vet Med, Dept Equine Surg, Vet Pl 1, A-1210 Vienna, Austria.
C3 University of Veterinary Medicine Vienna
RP Florczyk, A (通讯作者)，Univ Vet Med, Dept Equine Surg, Vet Pl 1, A-1210 Vienna, Austria.
EM agnieszka.florczyk@vetmeduni.ac.at
OI Rosser, Julie/0000-0002-4719-7205
CR BERTONE AL, 1989, VET CLIN N AM-EQUINE, V5, P539, DOI 10.1016/S0749-0739(17)30573-4
   Gemeinhardt KD, 2005, EQUINE VET EDUC, V17, P27, DOI 10.1111/j.2042-3292.2005.tb00331.x
   Krug E, 2011, INJURY S1, V42, P51
   Mouës CM, 2011, AM J SURG, V201, P544, DOI 10.1016/j.amjsurg.2010.04.029
   Stannard JP, 2010, INJURY, V41, P780, DOI 10.1016/j.injury.2009.08.011
   Vikatmaa P, 2008, EUR J VASC ENDOVASC, V36, P438, DOI 10.1016/j.ejvs.2008.06.010
   Wilmink JM, 2005, VET CLIN N AM-EQUINE, V21, P15, DOI 10.1016/j.cveq.2004.11.014
NR 7
TC 10
Z9 12
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0737-0806
EI 1542-7412
J9 J EQUINE VET SCI
JI J. Equine Vet. Sci.
PD AUG
PY 2017
VL 55
BP 9
EP 11
DI 10.1016/j.jevs.2017.01.005
PG 3
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FD4TD
UT WOS:000407523900002
DA 2026-07-24
ER
PT J
AU Scheer, HS
   Kaiser, M
   Zingg, U
AF Scheer, H. S.
   Kaiser, M.
   Zingg, U.
TI Results of directly applied activated carbon cloth in chronic wounds: a
   preliminary study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE activated carbon dressing; wound healing; Zorflexnurses
ID VACUUM-ASSISTED CLOSURE; DRESSINGS; THERAPY; CARE; PREDICT; TRIAL
AB Objective: Activated carbon (AC) has been used in wound therapy as an active substance inside dressings. Applying AC directly on a wound is a new concept. The aim of this study was to analyse the outcomes of chronic wounds which were managed with directly applied activated carbon knitted cloth (ACC, Zorflex) in Swiss patients.
   Method: A retrospective analysis of the records of all patients with chronic wounds treated with ACC between 1 October 2013 and 31 December 2015 in an outpatient wound clinic. Chronic was defined as a wound being present for >3 weeks. Malignant wounds were excluded. The main outcome was the time to complete closure or readiness for spilt-thickness skin grafting (STSG). Descriptive data, including nutritional status and angiology results were obtained.
   Results: There were 36 women and 34 men, median age 68 years old. The median body mass index (BMI) 28.1kg/m(2) and 76% (n=53) of patients had comorbidities. Angiology exam results showed signs of reduced arterial perfusion in 13% (n=9) of patients and malnutrition in 11% (n=8). Of the wounds included 34% (n=24) were on the trunk and 66% (n=46) on the extremities. The median wound size was 6.9cm(2) (range: 0.1-300cm(2)). The wounds on the trunk were larger than wounds on extremities (10 versus 2cm(2)). Overall, median time to closure was 51 days. In 94% (n=66) of patients, wounds closed without further intervention and 6% (n=4) underwent STSG. Patients with comorbidities showed longer wound healing times compared with those without. No adverse events such as allergies or skin irritation occurred. Cost analysis, including personnel and material and stratified according known wound closure times, showed ACC (US$1252) to be like hydrocolloids (US$1128), but substantially lower than white gauze (US$3026) and negative pressure wound therapy (NPWT) (US$2578).
   Conclusion: ACC applied directly on chronic wounds of different aetiology is safe with short closure times. The cost efficiency is high. It combines the positive features of other wound dressings, such as hydrocolloids and NPWT, without their disadvantages. The dressing change of ACC is easy and non-specialised nurses or even patients themselves can be taught to perform it.
C1 [Scheer, H. S.; Kaiser, M.; Zingg, U.] Limmattal Hosp, Dept Surg, Zurich, Switzerland.
RP Zingg, U (通讯作者)，Limmattal Hosp, Dept Surg, Zurich, Switzerland.
EM urs.zingg@spital-limmattal.ch
OI Scheer, Helene Sophie/0000-0001-9124-573X
CR Anderson Kristin, 2012, J Am Coll Clin Wound Spec, V4, P84, DOI 10.1016/j.jccw.2014.03.001
   [Anonymous], 2006, Guidance for Industry: Chronic Cutaneous Ulcer and Burn Wounds-Developing Products for Treatment
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   Gillitzer R, 2002, HAUTARZT, V53, P130, DOI 10.1007/s00105-001-0335-3
   Haycocks S., 2014, Diabetic Foot J., V17, P74
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   Isago T, 2003, J DERMATOL, V30, P596, DOI 10.1111/j.1346-8138.2003.tb00441.x
   Jafari SMS, 2014, MICROVASC RES, V94, P1, DOI 10.1016/j.mvr.2014.04.007
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   Kim JJ, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001211
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Powers JG, 2013, DERMATOL THER, V26, P197, DOI 10.1111/dth.12055
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   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
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NR 27
TC 5
Z9 6
U1 0
U2 12
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2017
VL 26
IS 8
BP 476
EP 481
DI 10.12968/jowc.2017.26.8.476
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FD5AD
UT WOS:000407542400008
PM 28795884
DA 2026-07-24
ER
PT J
AU Philip, B
   McCluskey, P
AF Philip, B.
   McCluskey, P.
TI Experience using closed incision negative pressure wound therapy in
   sternotomy patients
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE closed incision negative pressure therapy; negative pressure wound
   therapy; sternotomy; wound healingincidence
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; SURGICAL INCISIONS;
   MANAGEMENT-SYSTEM; RISK-FACTORS; INFECTIONS; COMPLICATIONS; MORTALITY;
   IMPACT; WALL
AB Objective: Postoperative delayed wound healing, surgical site infections (SSIs), and other wound complications are associated with increased morbidity and health-care costs. In cardiothoracic surgery, wound complications can have life-threatening consequences. In recent years, negative pressure wound therapy (NPWT) has been applied over closed surgical incisions to help reduce tension and protect from external contamination. We report our initial experiences using a closed incision negative pressure therapy (ciNPT) over clean, closed sternotomy incisions at an Irish tertiary referral centre.
   Method: A retrospective record review identified 10 patients (4 females, 6 males) where ciNPT was used following sternotomy for cardiac surgery or other mediastinal surgery between January 2012 and March 2013.
   Results: The patients had an average age of 71.5 +/- 14.18 years (range: 44-89 years). Patient comorbidities included obesity, hypertension, active tobacco use, chronic obstructive pulmonary disease, and diabetes mellitus. Patients underwent coronary artery bypass grafting (CABG), aortic valve replacement (AVR), AVR and CABG, or removal of a thymic mass or mediastinal cyst. ciNPT was left in place for an average of 6 +/- 0.82 days. All incisions healed without complications.
   Conclusion: ciNPT use should be considered for patients at risk for postoperative SSI development or other wound complications.
C1 [Philip, B.; McCluskey, P.] Cork Univ Hosp, Dept Cardiothorac Surg, Cork, Ireland.
C3 University College Cork
RP Philip, B (通讯作者)，Cork Univ Hosp, Dept Cardiothorac Surg, Cork, Ireland.
EM bejoyphilip@gmail.com
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NR 31
TC 9
Z9 10
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2017
VL 26
IS 8
BP 491
EP 495
DI 10.12968/jowc.2017.26.8.491
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FD5AD
UT WOS:000407542400010
PM 28795891
DA 2026-07-24
ER
PT J
AU Peinemann, F
AF Peinemann, Frank
TI Negative Pressure Wound Therapy: Randomised Controlled Trials from 2000
   to 2015
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE systematic reviews; evidence-based medicine; randomised trials; negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; REVIEWS
AB Background Negative pressure wound therapy is believed to promote wound healing. However, the results from randomised controlled trials (RCTs) are inconsistent. Systematic reviews indicate unclear evidence, due in part to low-quality RCTs, calling for more RCTs of higher quality.
   Methods This study aimed to ascertain the number of RCTs as well as systematic reviews on RCTs published during the time period from 2000 to 2015. Various search strategies were used to identify studies in PubMed, Cochrane Library, Google, references lists of retrieved articles, and institutions that issue evidence reports. The study also aimed to investigate the quality of included RCTs. It evaluated whether or not the randomisation methodology was comprehensibly described and conclusions were based on acceptable endpoints.
   Results The search for studies resulted in 456 different references, which included a total of 49 RCTs and 81 systematic reviews. Randomisation was comprehensibly described in 37% (18 out of 49 RCTs) and concealment of allocation in 10% (5 out of 49 RCTs). Conclusions were based on acceptable endpoints in 55% (27 out of 49 RCTs). A superior efficacy of NPWT versus standard was stated in 65% (32 out of 49 RCTs). In studies based on acceptable endpoints, this proportion was 16% (8 out of 49 RCTs). Systematic reviews repeatedly included identical study data.
   Conclusion The published literature, reviewed over a period of more than 16 years, contains more systematic reviews incorporating secondary data from other RCTs than actual RCTs reporting primary clinical data. Many RCTs seem to be of low quality, which considerably limits the validity of the corresponding conclusions. The ongoing production of potentially unreliable RCTs and redundant systematic reviews does not seem to provide convincing answers to crucial clinical research questions. Therefore, a change in strategy should be contemplated to observe individual characteristics of the respective persons and the wounds in question.
C1 [Peinemann, Frank] Uniklin Koln, Klin Kinder & Jugendmed, Kerpener Str 62, D-50937 Cologne, Germany.
C3 University of Cologne
RP Peinemann, F (通讯作者)，Uniklin Koln, Klin Kinder & Jugendmed, Kerpener Str 62, D-50937 Cologne, Germany.
EM pubmedprjournal@gmail.com
RI /H-2800-2019
CR Acosta S, 2013, INT WOUND J, V10, P377, DOI 10.1111/j.1742-481X.2012.00993.x
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   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
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   Higgins J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000049
   Hopewell S, 2008, DECISION TOOL UPDATI
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
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   Tsertsvadze A, 2011, J CLIN EPIDEMIOL, V64, P1208, DOI 10.1016/j.jclinepi.2011.03.011
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NR 26
TC 3
Z9 3
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD JUN
PY 2017
VL 142
IS 3
BP 267
EP 274
DI 10.1055/s-0043-104697
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FD5UW
UT WOS:000407596300017
PM 28641353
DA 2026-07-24
ER
PT J
AU Schmidt, F
   Mennigen, R
   Vowinkel, T
   Neumann, PA
   Senninger, N
   Palmes, D
   Laukoetter, MG
AF Schmidt, Fabian
   Mennigen, Rudolf
   Vowinkel, Thorsten
   Neumann, Philipp A.
   Senninger, Norbert
   Palmes, Daniel
   Laukoetter, Mike G.
TI Endoscopic Vacuum Therapy (EVT)-a New Concept for Complication
   Management in Bariatric Surgery
SO OBESITY SURGERY
LA English
DT Article
DE Laparoscopic sleeve gastrectomy; Endoscopic vacuum therapy; EVT;
   Negative pressure wound therapy; Bariatric surgery; Obesity; Anastomotic
   leakage; Postoperative complications; Therapeutic endoscopy
ID Y GASTRIC BYPASS; UPPER GASTROINTESTINAL-TRACT; ANASTOMOTIC LEAKAGE;
   SLEEVE GASTRECTOMY; ESOPHAGEAL PERFORATIONS; ASSISTED CLOSURE; STENTS;
   INSUFFICIENCY; METAANALYSIS; MORTALITY
AB Background Bariatric surgery is the most efficient therapy for morbid obesity. Staple line and anastomotic leakage are the most feared postoperative complications after Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy (LSG). Traditional treatment options like revisional surgery and endoscopic stent placement are associated with high morbidity and mortality as well as variable success rates. Endoscopic vacuum therapy (EVT) has shown to be a new successful and feasible treatment option for leaks of different etiology after major gastro-esophageal surgery.
   Method We report a case of the EVT principle being applied in a patient with three major leaks located apart from each other within the gastric staple line after LSG for morbid obesity (BMI 62.7). EVT was initiated on postoperative day 8.
   Results In total, 18 endoscopic interventions were performed in 72 days, the vacuum sponge being replaced endoscopically every 4 days. Hospital length of stay was 106 days. No relevant procedure related complications were observed during the course of therapy and during the follow up.
   Conclusion EVT of postoperative leaks in the upper GI tract has been shown to be feasible and safe. It combines defect closure and effective drainage and allows a periodic inspection of the wound cavity. In case of therapeutic failure, it does not jeopardize surgical repair or stent placement. Even though the techniques and materials used in EVT still vary considerably according to local expertise, EVT has the potential to succeed as a nonsurgical, feasible, safe, and effective treatment option for postoperative leaks in bariatric surgery.
C1 [Schmidt, Fabian; Mennigen, Rudolf; Vowinkel, Thorsten; Neumann, Philipp A.; Senninger, Norbert; Palmes, Daniel; Laukoetter, Mike G.] Univ Hosp Muenster, Dept Gen & Visceral Surg, Albert Schweitzer Campus 1,Bldg W1, D-48149 Munster, Germany.
C3 University of Munster
RP Laukoetter, MG (通讯作者)，Univ Hosp Muenster, Dept Gen & Visceral Surg, Albert Schweitzer Campus 1,Bldg W1, D-48149 Munster, Germany.
EM laukoetter@uni-muenster.de
RI Neumann, Philipp-Alexander/AAE-2940-2019
CR Aurora AR, 2012, SURG ENDOSC, V26, P1509, DOI 10.1007/s00464-011-2085-3
   Ballesta C, 2008, OBES SURG, V18, P623, DOI 10.1007/s11695-007-9297-6
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   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Dasari BVM, 2014, ANN SURG, V259, P852, DOI 10.1097/SLA.0000000000000564
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   Eubanks S, 2008, J AM COLL SURGEONS, V206, P935, DOI 10.1016/j.jamcollsurg.2008.02.016
   Fernandez AZ Jr, 2004, SURG ENDOSC, V18, P193, DOI 10.1007/s00464-003-8926-y
   Gonzalez R, 2007, J AM COLL SURGEONS, V204, P47, DOI 10.1016/j.jamcollsurg.2006.09.023
   Hirdes MMC, 2011, ENDOSCOPY, V43, P156, DOI 10.1055/s-0030-1255849
   Jones KB, 2006, OBES SURG, V16, P721
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   Laukoetter MG, 2016, SURG ENDOSC
   Livingston EH, 2005, SURG CLIN N AM, V85, P853, DOI 10.1016/j.suc.2005.04.007
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   Murino A, 2015, OBES SURG, V25, P1569, DOI 10.1007/s11695-015-1596-8
   Overcash WT, 2008, OBES SURG, V18, P882, DOI 10.1007/s11695-008-9452-8
   Papavramidis TS, 2008, J GASTROEN HEPATOL, V23, P1802, DOI 10.1111/j.1440-1746.2008.05545.x
   Schaheen L, 2014, AM J SURG, V208, P536, DOI 10.1016/j.amjsurg.2014.05.011
   Schniewind B, 2013, SURG ENDOSC, V27, P3883, DOI 10.1007/s00464-013-2998-0
   Schorsch T, 2014, CHIRURG, V85, P1081, DOI 10.1007/s00104-014-2764-4
   Seyfried F, 2013, ENDOSCOPY, V45, pE267, DOI 10.1055/s-0033-1344569
   Sjöström L, 2007, NEW ENGL J MED, V357, P741, DOI 10.1056/NEJMoa066254
   Smallwood NR, 2016, SURG ENDOSC, V30, P2473, DOI 10.1007/s00464-015-4501-6
   Stahl RD, 2006, AM SURGEON, V72, P590
   Wallstabe I, 2010, ENDOSCOPY, V42, pE165, DOI 10.1055/s-0029-1244150
   Weidenhagen R, 2010, ANN THORAC SURG, V90, P1674, DOI 10.1016/j.athoracsur.2010.07.007
   Zellmer JD, 2014, AM J SURG, V208, P903, DOI 10.1016/j.amjsurg.2014.08.002
NR 32
TC 29
Z9 32
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD SEP
PY 2017
VL 27
IS 9
BP 2499
EP 2505
DI 10.1007/s11695-017-2783-6
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FE1IJ
UT WOS:000407971600043
PM 28695459
DA 2026-07-24
ER
PT J
AU Denaro, V
   Longo, UG
   Salvatore, G
   Candela, V
   Maffulli, N
AF Denaro, Vincenzo
   Longo, Umile Giuseppe
   Salvatore, Giuseppe
   Candela, Vincenzo
   Maffulli, Nicola
TI Subcutaneous emphysema of the leg after hardware removal and bone
   allografting for infected non-union of the distal femur
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Gangrene; Fracture; Hardware removal; Femur
ID LONG BONES; IN-VITRO; FRACTURES
AB Background: Infected non-unions of the supracondylar region of the femur are uncommon. Even though hardware removal is a common procedure, it may lead to complications, including neurovascular injury, refracture, worsening pain or recurrence of deformity.
   Case presentation: We report on a male who developed subcutaneous emphysema of the leg after hardware removal and bone allografting for an infected non-union of the distal femur. He was managed by debridement of the surgical wound, antibiotic therapy, multiple fasciotomies, and application of a VAC (vacuum-assisted closure) system.
   Conclusions: Although subcutaneous emphysema of the leg after hardware removal and bone allografting for infected non-union of the distal femur is extremely rare, the potential life treating complications and their potential impact on the functional status of the patient have to be taken into consideration when counseling patients about this procedure. Even when it is not possible to identify a bacterial pathogen responsible for the subcutaneous emphysema of the leg, prompt intervention may save the limb of the patient.
C1 [Denaro, Vincenzo; Longo, Umile Giuseppe; Salvatore, Giuseppe; Candela, Vincenzo] Campus Biomed Univ, Dept Orthopaed & Trauma Surg, Via Alvaro Portillo 200, I-00128 Rome, Italy.
   [Maffulli, Nicola] Mile End Hosp, Barts & London Sch Med & Dent, Ctr Sports & Exercise Med, 275 Bancroft Rd, London E1 4DG, England.
   [Maffulli, Nicola] Univ Salerno, Sch Med, Salerno, Italy.
C3 University Campus Bio-Medico - Rome Italy; University of London; Queen
   Mary University London; Barts Health NHS Trust; Mile End Hospital;
   University of Salerno
RP Longo, UG (通讯作者)，Campus Biomed Univ, Dept Orthopaed & Trauma Surg, Via Alvaro Portillo 200, I-00128 Rome, Italy.
EM g.longo@unicampus.it
RI Denaro, Vincenzo/K-9567-2016; Candela, Vincenzo/IQU-2446-2023; Longo,
   Umile Giuseppe/K-9147-2016; Salvatore, Giuseppe/AAC-5947-2022; Maffulli,
   Nicola/A-1839-2014
OI Candela, Vincenzo/0000-0003-0047-2748; Longo, Umile
   Giuseppe/0000-0003-4063-9821; Salvatore, Giuseppe/0000-0003-1937-3272; 
CR Bose D, 2015, BONE JOINT J, V97B, P814, DOI 10.1302/0301-620X.97B6.33276
   Busam ML, 2006, J AM ACAD ORTHOP SUR, V14, P113, DOI 10.5435/00124635-200602000-00006
   Centers for Disease Control and Prevention (CDC), 2001, MMWR Morb Mortal Wkly Rep, V50, P1035
   Chapman MW, 1999, J BONE JOINT SURG AM, V81A, P1217, DOI 10.2106/00004623-199909000-00003
   Jain AK, 2005, CLIN ORTHOP RELAT R, P57, DOI 10.1097/01.blo.0000152868.29134.92
   Jain A, 2015, INDIAN J ORTHOP, V49, P637, DOI 10.4103/0019-5413.168764
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   Kainer MA, 2002, P 40 ANN INF DIS SOC
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   Longo Umile Giuseppe, 2012, Open Orthop J, V6, P564, DOI 10.2174/1874325001206010564
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NR 17
TC 2
Z9 2
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD AUG 15
PY 2017
VL 18
AR 351
DI 10.1186/s12891-017-1706-y
PG 6
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA FE3AN
UT WOS:000408088900002
PM 28810893
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chiang, N
   Rodda, OA
   Sleigh, J
   Vasudevan, T
AF Chiang, Nathaniel
   Rodda, Odette A.
   Sleigh, Jamie
   Vasudevan, Thodur
TI Effects of topical negative pressure therapy on tissue oxygenation and
   wound healing in vascular foot wounds
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID MICROVASCULAR BLOOD-FLOW; VACUUM-ASSISTED CLOSURE; DIABETIC FOOT;
   RANDOMIZED-TRIAL; ULCERS; MANAGEMENT
AB Objective: Topical negative pressure (TNP) therapy is widely used in the treatment of acute wounds in vascular patients on the basis of proposed multifactorial benefits. However, numerous recent systematic reviews have concluded that there is inadequate evidence to support its benefits at a scientific level. This study evaluated the changes in wound volume, surface area, depth, collagen deposition, and tissue oxygenation when using TNP therapy compared with traditional dressings in patients with acute high-risk foot wounds.
   Methods: This study was performed with hospitalized vascular patients. Forty-eight patients were selected with an acute lower extremity wound after surgical debridement or minor amputation that had an adequate blood supply without requiring further surgical revascularization and were deemed suitable for TNP therapy. The 22 patients who completed the study were randomly allocated to a treatment group receiving TNP or to a control group receiving regular topical dressings. Wound volume and wound oxygenation were analyzed using a modern stereophotographic wound measurement system and a hyperspectral transcutaneous oxygenation measurement system, respectively. Laboratory analysis was conducted on wound biopsy samples to determine hydroxyproline levels, a surrogate marker to collagen.
   Results: Differences in clinical or demographic characteristics or in the location of the foot wounds were not significant between the two groups. All patients, with the exception of two, had diabetes. The two patients who did not have diabetes had end-stage renal failure. There was no significance in the primary outcome of wound volume reduction between TNP and control patients on day 14 (44.2% and 20.9%, respectively; P = .15). Analyses of secondary outcomes showed a significant result of better healing rates in the TNP group by demonstrating a reduction in maximum wound depth at day 14 (36.0% TNP vs 17.6% control; P = .03). No significant findings were found for the other outcomes of changes in hydroxyproline levels (58.0% TNP vs 94.5% control; P = .32) or tissue perfusion by tissue oxyhemoglobin saturation (19.4% TNP vs 12.0% control; P = .07) at day 14. At 1 year of follow-up, there were no significant outcomes in the analysis of wound failure, major amputation, and overall survival rates between the two groups.
   Conclusions: In this pilot study, applying TNP to acute high-risk foot wounds in patients with diabetes or end-stage renal failure improved the wound healing rate in reference to wound depth. This suggests that TNP may play a role in enhancing wound healing. This study sets the foundation for larger studies to evaluate the superiority of TNP over traditional dressings in high-risk foot wounds.
C1 [Chiang, Nathaniel; Sleigh, Jamie; Vasudevan, Thodur] Waikato Hosp, Dept Vasc Surg, Hamilton, New Zealand.
   [Rodda, Odette A.] St Vincents Hosp, Dept Vasc Surg, Melbourne, Vic, Australia.
C3 Waikato Hospital; St Vincent's Health; St Vincent's Hospital Melbourne;
   NSW Health; St Vincents Hospital Sydney
RP Rodda, OA (通讯作者)，St Vincents Hosp, Dept Vasc Surg, 41 Victoria Parade, Fitzroy, Vic 3065, Australia.
EM odette.rodda@svha.org.au
RI Vasudevan, Thodur/GRY-2923-2022
FU Waikato Medical Research Foundation; Faculty Research Development Fund;
   Braemar Charitable Trust Research Grant; Bayers Health Care Fund;
   Department Grant-in-aid, Performance-Based Research Fund Allocation,
   Postgraduate Student Fund; PReSS Fund
FX This work was supported by the Waikato Medical Research Foundation,
   Faculty Research Development Fund, Braemar Charitable Trust Research
   Grant, Bayers Health Care Fund, Department Grant-in-aid,
   Performance-Based Research Fund Allocation, Postgraduate Student Fund,
   and the PReSS Fund. There were no significant relationships with
   HyperMed Inc (developer of OxyVu), Intermed (manufacturer of VAC), and
   ARANZ (manufacturer of the FastScan and Silhouette Mobile). The devices
   were bought and leased using independent research funds. There were no
   conflicts of interest that were directly relevant to the content of this
   manuscript.
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NR 29
TC 43
Z9 55
U1 1
U2 26
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD AUG
PY 2017
VL 66
IS 2
BP 564
EP 571
DI 10.1016/j.jvs.2017.02.050
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA FE4YC
UT WOS:000408218200106
PM 28583732
OA Bronze
DA 2026-07-24
ER
PT J
AU Li, PY
   Yang, D
   Liu, D
   Sun, SJ
   Zhang, LY
AF Li, P. -Y.
   Yang, D.
   Liu, D.
   Sun, S. -J.
   Zhang, L. -Y.
TI REDUCING SURGICAL SITE INFECTION WITH NEGATIVE-PRESSURE WOUND THERAPY
   AFTER OPEN ABDOMINAL SURGERY: A PROSPECTIVE RANDOMIZED CONTROLLED STUDY
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; surgical wound infection; risk factors;
   abdominal wound closure techniques; wound healing; surgical procedures
ID EVIDENCE-BASED RECOMMENDATIONS; VACUUM-ASSISTED CLOSURE; COLORECTAL
   SURGERY; INTERNATIONAL CONSENSUS; PREVENTION; METAANALYSIS; LAPAROTOMY;
   MANAGEMENT; INCISIONS; SYSTEM
AB Background and Aims: Surgical site infection, in particular superficial incision infection, is a common type of complication following abdominal surgery. Negative-pressure wound therapy has been confirmed to reduce the incidence of surgical site infection in various surgeries, but there are few prospective randomized studies into its application to abdominal surgery.
   Material and Methods: A prospective randomized controlled study was conducted in which patients with abdominal surgery and open surgery were randomly divided into a negative-pressure wound therapy experimental group and a gauze-covering control group. Information about demographic data, type of surgery, surgical sites, incision treatment outcomes, surgical site infection factors, and follow-up was recorded.
   Results: From May 2015 to December 2015, 71 patients were enrolled in this study, including 33 in the experimental group and 38 in the control group. There were 10 cases of incision complications, all superficial infections, with an incidence of 14.1%. The surgical site infection incidence was statistically different between the experimental and control groups (3.0% vs 23.7%, p=0.031). Multivariate logistic regression analysis showed that incision length >= 20cm increased the surgical site infection incidence (odds ratio value of 15.576, p=0.004) and that the application of negative-pressure wound therapy reduced the surgical site infection incidence (odds ratio value of 0.073, p=0.029).
   Conclusion: Negative-pressure wound therapy can reduce the incidence of surgical site infection in open abdominal surgery.
C1 [Li, P. -Y.; Yang, D.; Liu, D.; Sun, S. -J.; Zhang, L. -Y.] Third Mil Med Univ, Inst Surg Res, State Key Lab Trauma Burns & Combined Injury, Trauma Ctr,Daping Hosp, Chongqing 400042, Peoples R China.
C3 Army Medical University
RP Zhang, LY (通讯作者)，Third Mil Med Univ, Inst Surg Res, State Key Lab Trauma Burns & Combined Injury, Trauma Ctr,Daping Hosp, Chongqing 400042, Peoples R China.
EM dpzhangly@163.com
FU New Techniques of Trauma Care [2012BAI11B01]
FX The authors declare support by grants from "New Techniques of Trauma
   Care" (2012BAI11B01).
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   Hsu CC, 2010, AM J PHYSIOL-CELL PH, V299, pC528, DOI 10.1152/ajpcell.00504.2009
   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
   Kilpadi DV, 2011, WOUND REPAIR REGEN, V19, P588, DOI 10.1111/j.1524-475X.2011.00714.x
   Kirkland KB, 1999, INFECT CONT HOSP EP, V20, P725, DOI 10.1086/501572
   Lee JS, 2011, J AM COLL SURGEONS, V213, P236, DOI 10.1016/j.jamcollsurg.2011.04.008
   Mangram AJ, 1999, AM J INFECT CONTROL, V27, P97, DOI 10.1016/S0196-6553(99)70088-X
   Mihaljevic AL, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0995-4
   Mihaljevic AL, 2014, ANN SURG, V260, P730, DOI 10.1097/SLA.0000000000000954
   Motie Mohammad Reza, 2014, Med J Islam Repub Iran, V28, P52
   Mueller TC, 2015, LANGENBECK ARCH SURG, V400, P167, DOI 10.1007/s00423-015-1279-x
   Pinkney TD, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f4305
   Runkel N, 2011, INJURY, V42, pS1, DOI 10.1016/S0020-1383(11)00041-6
   Soares KC, 2015, AM J SURG, V209, P324, DOI 10.1016/j.amjsurg.2014.06.022
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
NR 31
TC 51
Z9 56
U1 1
U2 14
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD SEP
PY 2017
VL 106
IS 3
BP 189
EP 195
DI 10.1177/1457496916668681
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FE5AL
UT WOS:000408224300001
PM 27609528
OA Bronze
DA 2026-07-24
ER
PT J
AU Wang, Z
   Bai, M
   Long, X
   Zeng, A
   Song, KX
   Wang, XJ
AF Wang, Zhi
   Bai, Ming
   Long, Xiao
   Zeng, Ang
   Song, Kexin
   Wang, Xiaojun
TI New protocol to treat Chinese patients with wound-derived acute severe
   illness
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Wound; emergency treatment; critical; salvage treatment mode; NPWT
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT; EXPERIENCE
AB Background and aim: Treatment of severe acute wounds caused by major injury or infection remains challenging. These wounds are often accompanied by comorbidities such as septic shock or multiple organ failure, in which the prognosis is poor. In China, patients with wound-derived acute severe illness are usually treated by conventional salvage approach, in which life support measures are prioritized before vital organ protection and wound repair. To improve patients' prognosis and quality of life after treatment, our institute established a new salvage protocol that simultaneously provided life-support measures and wound care for patients with wound-derived acute severe illness. This study provided a retrospective review on the outcomes of patients treated with the new salvage protocol. Methods: Records from 2011 to 2013 at Peking Union Medical College Hospital in Beijing, China were reviewed to identify patients with wound-derived acute severe illness treated with the new salvage protocol. The protocol included the proactive wound treatment using negative pressure wound therapy (NPWT). During the treatment with NPWT, emergency department and ICU administered adjunctive therapies as needed. Results: Fifty-six patients were treated with the new protocol. All patients had septic shock and 29/56 (51.8%) required mechanical ventilation. Of patients treated according to the new protocol, 21/56 (37.5%) fully recovered and 29/56 (51.8%) improved sufficiently to be transferred to a general ward. Six patients (10.7%) died of causes unlikely related to NPWT. Conclusion: The new salvage protocol implemented in our institute provided wound care proactively and is beneficial to patients with wound-derived acute severe illness.
C1 Chinese Acad Med Sci, Peking Union Med Coll Hosp, Plast & Cosmet Surg Ctr, Beijing, Peoples R China.
   Peking Union Med Coll, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College
RP Wang, XJ (通讯作者)，Beijing Union Med Coll Hosp, Plast & Cosmet Surg Ctr, 1 Shuaifuyuan, Beijing 100730, Peoples R China.
EM pumchwxj@163.com
RI wang, xiaojun/NFT-0476-2025; /AAT-4908-2020
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Driver VR, 2010, J VASC SURG, V52, p17S, DOI 10.1016/j.jvs.2010.06.003
   [方国恩 Fang Guoen], 2002, [中国实用外科杂志, Chinese Journal of Practical Surgery], V22, P70
   Gibney RTN, 2014, KIDNEY INT, V85, P1049, DOI 10.1038/ki.2013.392
   Gottrup F, 2004, AM J SURG, V187, p38S, DOI 10.1016/S0002-9610(03)00303-9
   Gottrup F, 2003, WOUND REPAIR REGEN, V11, P452, DOI 10.1046/j.1524-475X.2003.11609.x
   Lu H, 2001, CHINESE J CRITICAL C, V21, P275
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   [杨帆 YANG Fan], 2009, [中华创伤杂志, Chinese Journal of Trauma], V25, P103
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   Zuo H, 1998, CHINESE J PRACTICAL, V18, P233
NR 13
TC 0
Z9 0
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 8
BP 12259
EP 12267
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FF1EX
UT WOS:000408643700108
DA 2026-07-24
ER
PT J
AU Liu, XC
   Liu, RR
   Chen, WQ
   Chen, G
AF Liu, Xiaochun
   Liu, Runrui
   Chen, Weiqing
   Chen, Ge
TI Retrospective analysis of challenging treatment of mesh infection after
   open parastomal hernia repair: a case report
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Parastomal hernia; open repair; mesh infection; vacuum sealing drainage
ID SURGERY
AB Parastomal hernia repair is still clinically challenging. The open surgery approach is associated with risk of mesh infection and the treatment of infected mesh is very difficult. We here report a special patient whose preoperative preparation was inadequate and we used the open surgery approach to repair his parastomal hernia. Postoperatively, his pulmonary infection was aggravated, and then wound hematoma, mesh infection, and sepsis occurred. After a series of comprehensive treatments, including respiratory and circulatory support, anti-infection treatment, Vacuum sealing drainage (VSD) application, his systemic and local infections were controlled, the mesh was preserved, and his parastomal hernia was no longer prolapsed. However now no guidelines help operators to determine whether to remove the infected mesh or not. The treatment process of the case was analyzed retrospectively here so as to provide hernia surgeons with clinical insights into the treatment of such challenging cases.
C1 [Liu, Xiaochun; Chen, Weiqing] Nanchang Univ, Dept Gen Surg 2, Affiliated Ganzhou Hosp, Ganzhou 341000, Jiangxi, Peoples R China.
   [Liu, Runrui] Xinfeng Cty Peoples Hosp Jiangxi Prov, Dept Gen Surg, Nanchang, Jiangxi, Peoples R China.
   [Chen, Ge] Shanghai Huadong Hosp, Dept Abdominal Wall Hernia Surg, Shanghai, Peoples R China.
C3 Nanchang University; Fudan University
RP Liu, XC (通讯作者)，Nanchang Univ, Dept Gen Surg 2, Affiliated Ganzhou Hosp, Ganzhou 341000, Jiangxi, Peoples R China.
EM lxcmail8@163.com
RI Chen, Weiqing/AFR-9449-2022; Liu, Xiaochun/O-2518-2017
CR Al Shakarchi J, 2014, TECH COLOPROCTOL, V18, P427, DOI 10.1007/s10151-013-1110-z
   Aquina CT, 2014, DIGEST SURG, V31, P366, DOI 10.1159/000369279
   Falagas ME, 2005, CLIN MICROBIOL INFEC, V11, P3, DOI 10.1111/j.1469-0691.2004.01014.x
   Hotouras A, 2013, COLORECTAL DIS, V15, pE202, DOI 10.1111/codi.12156
   Kathju S, 2015, SURG INFECT, V16, P45, DOI 10.1089/sur.2014.026
   Klinge U, 2012, HERNIA, V16, P251, DOI 10.1007/s10029-012-0913-6
   Li WH, 2015, INT J CLIN EXP MED, V8, P16112
   Liang R, 2016, CURR OPIN OBSTET GYN, V28, P413, DOI 10.1097/GCO.0000000000000313
   Liu FD, 2015, GENET MOL RES, V14, P14387, DOI 10.4238/2015.November.18.2
   Lupinacci RM, 2014, SURG INNOV, V21, P600, DOI 10.1177/1553350613520514
   Mavros MN, 2011, WORLD J SURG, V35, P2389, DOI 10.1007/s00268-011-1266-5
   Szczepkowski M, 2015, VIDEOSURGERY MINIINV, V10, P1, DOI 10.5114/wiitm.2015.50052
   Toro A, 2010, S AFR J SURG, V48, P135
   Trunzo JA, 2009, HERNIA, V13, P545, DOI 10.1007/s10029-009-0470-9
NR 14
TC 1
Z9 1
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 8
BP 12623
EP 12627
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FF1EX
UT WOS:000408643700159
DA 2026-07-24
ER
PT J
AU Yang, C
   Goss, SG
   Alcantara, S
   Schultz, G
   Lantis, JC
AF Yang, Chun
   Goss, Selena G.
   Alcantara, Sean
   Schultz, Greg
   Lantis, John C., II
TI Effect of Negative Pressure Wound Therapy With Instillation on Bioburden
   in Chronically Infected Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE biofilm; planktonic bacteria; negative pressure wound therapy with
   installation; debridement; wound bed preparation
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EXPERIENCE; BIOFILMS; RESISTANCE;
   IRRIGATION; MECHANISMS; BACTERIA
AB Introduction. Standard negative pressure wound therapy (NPWT) has been shown to help close wounds despite increasing planktonic bioburden. Both planktonic and biofilm critical colonization are associated with delayed wound healing; therefore, reducing microbial colonization is thought to aid wound healing. The use of NPWT with topical antimicrobial irrigation solution has previously shown reduction in quantitative planktonic bioburden when combined with sharp debridement in chronic wounds. Objective. The goal of this study was to evaluate the effectiveness of NPWT with instillation (NPWTi) on biofilm of chronic wounds. Materials and Methods. A prospective, randomized trial was conducted. Following sharp debridement, 20 patients with chronic wounds were randomized to 1 week of either NPWTi with 0.125% sodium hypochlorite solution (n = 10) or NPWT without instillation (n = 10). Serial wound biopsy was performed predebridement, postdebridement, and after 1 week of study therapy to test for quantitative nonplanktonic or biofilm-protected bacteria. Results. As expected, there was no difference in change in wound size between the 2 groups at 1 week. The NPWTi group had a mean reduction in quantitative biofilm-protected bacteria of 48%, while the NPWT without instillation group had a mean increase of 14% (P < .05). Discussion. Consistent with previous studies, this trial demonstrates that NPWTi with dilute sodium hypochlorite solution is effective at reducing non planktonic bioburden of chronically, critically colonized wounds. Conclusions. Therefore, based on this and previously published work, this therapy provides both planktonic and nonplanktonic bioburden reduction as well as NPWT benefits and may be a tool for the preparation of infected wound beds prior to definitive closure.
C1 [Yang, Chun; Goss, Selena G.; Alcantara, Sean; Lantis, John C., II] Mt Sinai St Lukes West Hosp, New York, NY USA.
   [Schultz, Greg] Univ Florida, Gainesville, FL USA.
C3 Mount Sinai Morningside; Mount Sinai West; State University System of
   Florida; University of Florida
RP Lantis, JC (通讯作者)，1090 Amsterdam Ave,Suite 12, New York, NY 10025 USA.
EM JLantis@chpnet.org
FU Acelity; Smith Nephew; Kerecis; Intregra
FX Dr. Schultz is a paid consultant for Acelity and Smith & Nephew. Dr.
   Lantis is a paid consultant for Acelity, Smith & Nephew, Kerecis, and
   Intregra.
CR [Anonymous], 2006, ADV SKIN WOUND CARE
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   Bagge N, 2000, APMIS, V108, P589, DOI 10.1034/j.1600-0463.2000.d01-102.x
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NR 29
TC 59
Z9 67
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2017
VL 29
IS 8
BP 240
EP 246
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FF2BK
UT WOS:000408702700005
PM 28570250
DA 2026-07-24
ER
PT J
AU Nherera, LM
   Trueman, P
   Karlakki, SL
AF Nherera, Leo M.
   Trueman, Paul
   Karlakki, Sudheer L.
TI Cost-effectiveness analysis of single-use negative pressure wound
   therapy dressings (sNPWT) to reduce surgical site complications (SSC) in
   routine primary hip and knee replacements
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID TRIAL
AB We sought to evaluate the cost-effectiveness of single-use negative pressure wound therapy in patients undergoing primary hip and knee replacements using effectiveness data from a recently completed non-blinded randomized controlled trial. A decision analytic model was developed from UK National Health Service perspective using data from a single-centre trial. 220 patients were randomized to treatment with either single-use negative pressure wound therapy or standard care i.e., film dressings of clinician choice and followed for 6 weeks. Outcomes included dressing changes, length of stay, surgical site complications, cost and quality adjusted life years. The randomized controlled trial reported a reduction in dressing changes (p = 0.002), SSC (p = 0.06) and LOS (p = 0.07) in favor of single-use negative pressure wound therapy compared with standard care. The model estimated 0.116 and 0.115 QALY gained, 0.98 and 0.92 complications avoided for single-use negative pressure wound therapy and standard care, respectively. The cost/patient was 5,602 pound ($7,954) and 6,713 pound ($9,559) for single-use negative pressure wound therapy and standard care respectively resulting in cost-saving of 1,132 pound ($1,607) in favor of single-use negative pressure wound therapy. Greater savings were observed in subgroups of higher risk patients with BMI >= 35 and ASA >= 3 i.e., 7,955 pound ($11,296) and 7,248 pound ($10,293), respectively. The findings were robust to a range of sensitivity analyses. In conclusion, single-use negative pressure wound therapy can be considered a cost saving intervention to reduce surgical site complications following primary hip and knee replacements compared with standard care. Providers should consider targeting therapy to those patients at elevated risk of surgical site complications to maximize efficiency.
C1 [Nherera, Leo M.; Trueman, Paul] Smith & Nephew Adv Wound Management, Kingston Upon Hull HU3 2BN, N Humberside, England.
   [Karlakki, Sudheer L.] Robert Jones & Agnes Hunt Orthopaed NHS Hosp Fdn, Oswestry SY10 7AG, Shrops, England.
C3 Smith & Nephew
RP Nherera, LM (通讯作者)，Smith & Nephew, Global Market Access, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM leo.nherera@smith-nephew.com
RI Nherera, Leo/L-1978-2019
OI Nherera, Leo/0000-0003-1758-9504
CR [Anonymous], 2016, NHS ELECT DRUG TARIF
   [Anonymous], 2015, Personal Social Services Research Unit
   de Lissovoy G, 2009, AM J INFECT CONTROL, V37, P387, DOI 10.1016/j.ajic.2008.12.010
   Department of Health, NHS REF COSTS 2014 2
   Fenwick E, 2005, BRIT J PSYCHIAT, V187, P106, DOI 10.1192/bjp.187.2.106
   Health Protection Agency, 2011, PROT SURV SURG SIT I
   Hospital Episode Statistics, 2011, PROV MONTHL PAT REP
   Husereau D, 2013, VALUE HEALTH, V16, P231, DOI 10.1016/j.jval.2013.02.002
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   Jenks PJ, 2014, J HOSP INFECT, V86, P24, DOI 10.1016/j.jhin.2013.09.012
   Karlakki S, 2013, BONE JOINT RES, V2, P276, DOI 10.1302/2046-3758.212.2000190
   Karlakki SL, 2016, BONE JOINT RES, V5, P328, DOI 10.1302/2046-3758.58.BJR-2016-0022.R1
   National Institute for Health and Clinical Excellence, 2008, PREV TREATM SURG SIT
   Pellino G, 2014, SURG INNOV, V21, P204, DOI 10.1177/1553350613496906
   PHE, 2015, SURV SURG SIT INF NH
   Poultsides LA, 2013, J ARTHROPLASTY, V28, P385, DOI 10.1016/j.arth.2012.06.027
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   Tanner J, 2009, J HOSP INFECT, V72, P243, DOI 10.1016/j.jhin.2009.03.021
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NR 21
TC 54
Z9 58
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2017
VL 25
IS 3
BP 474
EP 482
DI 10.1111/wrr.12530
PG 9
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA FF3BT
UT WOS:000408771200013
PM 28370637
OA Bronze
DA 2026-07-24
ER
PT J
AU Ruhstaller, K
   Downes, KL
   Chandrasekaran, S
   Srinivas, S
   Durnwald, C
AF Ruhstaller, Kelly
   Downes, Katheryne L.
   Chandrasekaran, Suchitra
   Srinivas, Sindhu
   Durnwald, Celeste
TI Prophylactic Wound Vacuum Therapy after Cesarean Section to Prevent
   Wound Complications in the Obese Population: A Randomized Controlled
   Trial (the ProVac Study)
SO AMERICAN JOURNAL OF PERINATOLOGY
LA English
DT Article
DE cesarean delivery; negative pressure wound therapy; obese; surgical site
   infection; wound complication
ID SURGICAL SITE INFECTION; HIGH-RISK; PRESSURE; DELIVERY
AB Objective The objective of this study was to perform a randomized controlled feasibility trial investigating negative pressure wound therapy (NPWT) system versus a standard postcesarean wound care (WC) on the development of a postoperative surgical site infection (SSI) and/or a wound dehiscence in obese women.
   Study Design This is a randomized controlled feasibility trial of obese women undergoing an unscheduled cesarean delivery. Women with an initial body mass index30 kg/m (2) who were4 cm dilated were included. Women were assigned to either a NPWT or standard WC. The primary outcome was a composite of wound morbidity at 4 weeks postpartum including SSI and/or wound opening (clinicaltrials.gov, NCT02128997). Continuous variables were analyzed with t -test and Wilcoxon rank-sum tests and categorical variables with Fisher's exact test.
   Results Of 136 women randomized, 67 received NPWT and 69 received standard WC. The 4-week follow-up rate was 88%. Maternal clinical and surgical characteristics were similar between the groups. The prevalence of the composite wound morbidity outcome was not different between those with NPWT and standard WC (4.9 vs. 6.9%; p =0.71).
   Conclusion Routine clinical use of a NPWT system after cesarean delivery did not result in a significant reduction of wound morbidity over standard WC.
C1 [Ruhstaller, Kelly; Downes, Katheryne L.; Srinivas, Sindhu; Durnwald, Celeste] Univ Penn, Dept Obstet & Gynecol, Perelman Sch Med, Maternal Child Hlth Res Ctr, Philadelphia, PA 19104 USA.
   [Chandrasekaran, Suchitra] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA.
C3 University of Pennsylvania; University of Washington; University of
   Washington Seattle
RP Durnwald, C (通讯作者)，Univ Penn, Maternal & Child Hlth Ctr, 3400 Spruce St, Philadelphia, PA 19104 USA.
EM celeste.durnwald@uphs.upenn.edu
OI Chandrasekaran, Suchitra/0000-0002-5964-1190
FU National Institute of Health Reproductive Epidemiology Training Gran
   [T32-HD007440]; Eunice Kennedy Shriver National Institute of Child
   Health and Human Development [K12HD001264] Funding Source: NIH RePORTER
FX This study was supported by the National Institute of Health
   Reproductive Epidemiology Training Gran(T32-HD007440). All study devices
   were provided by Acelity. The funding sources had no role in study
   design, data collection, or analysis.
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   Olsen MA, 2010, INFECT CONT HOSP EP, V31, P276, DOI 10.1086/650755
   Rouse DJ, 2015, OBSTET GYNECOL, V125, P297, DOI 10.1097/AOG.0000000000000659
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Swift SH, 2015, J REPROD MED, V60, P211
   Tuuli MG, 2016, NEW ENGL J MED, V374, P647, DOI 10.1056/NEJMoa1511048
NR 13
TC 36
Z9 38
U1 0
U2 6
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0735-1631
EI 1098-8785
J9 AM J PERINAT
JI Am. J. Perinatol.
PD SEP
PY 2017
VL 34
IS 11
BP 1125
EP 1130
DI 10.1055/s-0037-1604161
PG 6
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA FF6BS
UT WOS:000409088700014
PM 28704847
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ciuntu, BM
   Vasiluta, C
   Negru, R
   Hultoana, R
   Ciuntu, R
   Georgescu, SO
   Sirbu, PD
   Azoicai, D
AF Ciuntu, Bogdan Mihnea
   Vasiluta, Ciprian
   Negru, Robert
   Hultoana, Roxana
   Ciuntu, Roxana
   Georgescu, Stefan Octavian
   Sirbu, Paul Dan
   Azoicai, Doina
TI Negative Pressure Therapy in the Surgical Treatment of Diabetic Foot
SO REVISTA DE CHIMIE
LA English
DT Article
DE negative pressure; diabetic foot; wound volume
ID VACUUM-ASSISTED CLOSURE; MECHANISMS; MELLITUS
AB The study aims to assess the significance of negative pressure therapy in the treatment of diabetic foot. The objectives intend to evaluate the healing time required after applying the method and the functional consequences for the patient. A prospective study was conducted on a sample of 37 patients with diabetic foot were monitored their clinical course between September 2014 - Apri12017, following negative pressure therapy. There were used vacuum assisted closure devices (VAC (TM) -Hartman) in order to apply negative pressure to the wound, while complying with specified settings (negative pressure, time of use of a kit) in accordance with patients' outcome. There were monitored changes in wound size (planimetric and volumetric measurement), their bacterial load and duration of treatment Healing was obtained in all cases, to an average hospital stay of 27.3 days and 8 days of therapy application. The negative result of microbial cultures was obtained after an average of 6.45 days by simultaneous application of negative pressure and antibiotic treatment according to the antibiogram. Skin grafts were necessary to close the defect in 4 cases. After basic treatment of the wound, auxiliary methods such as negative pressure contribute to the healing. ln patients with diabetic foot who were required surgical intervention, the use of negative pressure therapy yielded a significant benefit in the preservation of the affected limb, after minimal excision. The results we obtained throughout our experience recommend use of NPTW technique as indication for abdominal wall surgery in closing abdominal wall defects, compartment syndrome and surgical site infection after prosthetic mesh.
C1 [Ciuntu, Bogdan Mihnea; Vasiluta, Ciprian; Hultoana, Roxana; Georgescu, Stefan Octavian] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Surg, 16 Univ Str, Iasi 700115, Romania.
   [Negru, Robert] Grigore T Popa Univ Med & Pharm, Fac Med, Med Dept 1, 16 Univ Str, Iasi 700115, Romania.
   [Ciuntu, Roxana] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Ophtalmol, 16 Univ Str, Iasi 700115, Romania.
   [Sirbu, Paul Dan] Grigore T Popa Univ Med & Pharm Iasi, Fac Gen Med, Dept Orthoped & Traumatol, Surg Sci 2, 16 Univ Str, Iasi 700115, Romania.
   [Azoicai, Doina] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Prevent Med & Inderdisciplinar, 16 Univ Str, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy
RP Ciuntu, BM (通讯作者)，Grigore T Popa Univ Med & Pharm, Fac Med, Dept Surg, 16 Univ Str, Iasi 700115, Romania.; Sirbu, PD (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Fac Gen Med, Dept Orthoped & Traumatol, Surg Sci 2, 16 Univ Str, Iasi 700115, Romania.
EM bogdanmciuntu@yahoo.com; pdsirbu@yahoo.com
RI Ciuntu, Bogdan/MTF-9477-2025; Negru, Robert/HDM-9550-2022; AZOICAI,
   DOINA/HDO-6161-2022; Sirbu, Paul-Dan/KBP-9023-2024
OI AZOICAI, DOINA/0000-0003-0423-4085; Sirbu, Paul-Dan/0000-0003-2806-0649
CR Adamkova M, 2005, Acta Chir Plast, V47, P24
   Badescu L, 2012, ROM BIOTECH LETT, V17, P7397
   Badescu L, 2014, J PHYSIOL BIOCHEM, V70, P355, DOI 10.1007/s13105-013-0309-9
   Badulescu O, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/169420
   Gravante G, 2007, OBES SURG, V17, P1325, DOI 10.1007/s11695-007-9236-6
   Huang CY, 2012, CONNECT TISSUE RES, V53, P187, DOI 10.3109/03008207.2011.642035
   Huljev D, 2005, WOUNDS, V17, P169
   Ingber DE, 2007, DEVELOPMENT, V134, P2541, DOI 10.1242/dev.003707
   Jeffcoate WJ, 2004, DIABETOLOGIA, V47, P2051, DOI 10.1007/s00125-004-1584-3
   Kairinos N, 2010, J PLAST RECONSTR AES, V63, P174, DOI 10.1016/j.bjps.2008.08.037
   Lancerotto L, 2012, SEMIN CELL DEV BIOL, V23, P987, DOI 10.1016/j.semcdb.2012.09.009
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   Orgill DP, 2009, SURGERY, V146, P40, DOI 10.1016/j.surg.2009.02.002
   Potter MJ, 2008, BURNS, V34, P164, DOI 10.1016/j.burns.2007.06.020
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Singh N, 2005, JAMA-J AM MED ASSOC, V293, P217, DOI 10.1001/jama.293.2.217
   Veresiu IA, 2015, DIABETES RES CLIN PR, V109, P293, DOI 10.1016/j.diabres.2015.05.020
NR 17
TC 11
Z9 11
U1 0
U2 15
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD JUL
PY 2017
VL 68
IS 7
BP 1648
EP 1651
PG 4
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA FF7ZJ
UT WOS:000409234600051
DA 2026-07-24
ER
PT J
AU Kindel, N
AF Kindel, Nicole
TI Improvised Skin Graft for a Large Superficial Hematoma A Case
   Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Hematoma; Hematoma treatment; Large hematoma; Superficial hematoma;
   Surgical management
AB BACKGROUND: Management of a hematoma is challenging when its size is substantial.
   CASE: This case report describes the successful surgical treatment of a large, superficial hematoma with an improvised skin graft and negative pressure wound therapy.
   CONCLUSIONS: We have found that using the patient's own skin for a skin graft may provide adequate wound coverage and decrease healing time. This method also eliminates the need for creating a donor site. This same procedure can be used on smaller lacerations or skin tears. We advocate detaching the skin flap completely before reattaching in order to prevent reperfusion injury and necrosis.
C1 [Kindel, Nicole] Kaiser Westside Med Ctr, 2875 NW Stucki Ave, Hillsboro, OR 97124 USA.
RP Kindel, N (通讯作者)，Kaiser Westside Med Ctr, 2875 NW Stucki Ave, Hillsboro, OR 97124 USA.
CR Chiummariello S, 2013, WOUNDS, V25, P324
   Daggett JR, 2013, INT J SURG CASE REP, V4, P1080, DOI 10.1016/j.ijscr.2013.07.036
   Limberg RM, 2011, J EMERGENCY MED, V41, P1
   Moradian S, 2016, INT WOUND J, V13, P283, DOI 10.1111/iwj.12426
   Pagan M, 2011, WOUND PRACT RES, V19, P20
   Vandervord JG, 2016, INT WOUND J, V13, P59, DOI 10.1111/iwj.12227
NR 6
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2017
VL 44
IS 5
BP 492
EP 494
DI 10.1097/WON.0000000000000364
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FG2OA
UT WOS:000409948400017
PM 28777123
DA 2026-07-24
ER
PT J
AU Ciuntu, BM
   Vasiluta, C
   Anton, N
   Ciuntu, R
   Damian, M
   Ciumanghel, A
   Blaj, M
   Azoicai, D
   Georgescu, SO
AF Ciuntu, Bogdan Mihnea
   Vasiluta, Ciprian
   Anton, Nicoleta
   Ciuntu, Roxana
   Damian, Mihaela
   Ciumanghel, Adi
   Blaj, Mihaela
   Azoicai, Doina
   Georgescu, Stefan Octavian
TI Negative Pressure Therapy in Abdominal Compartment Syndrome
SO REVISTA DE CHIMIE
LA English
DT Article
DE Negative pressure therapy; comportament syndrome; acute pancreatitis
ID EXPERIMENTAL DIABETES-MELLITUS; SEVERE ACUTE-PANCREATITIS;
   INTRAABDOMINAL PRESSURE; HYPERTENSION
AB The abdominal vacuum-assisted closure (VAC) system has been introduced, providing a new possibility to treat an open abdomen. Abdominal compartment syndrome has a great relevance in surgical practice and patient care in critical condition due to the effects of increased pressure in the enclosed space of the abdomen can lead to multiple organ failure. A prospective study was conducted on a sample of 15 patients with severe acute pancreatitis (SAP) was retrospectively analyzed, following the incidence of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS), the effectiveness of the therapeutic methods applied in reducing the intra-abdominal pressure (PIA), the evolution of severity scores, lenght of stay in intensive care unit between January 2014 - March 2017, following negative pressure therapy. There were used vacuum assisted closure devices (VAC (TM) -Hartman) in order to apply negative pressure to the open abdomen, while complying with specified settings in accordance with patients' outcome. Surgery for abdominal decompression in PAS with SCA is an emergency and was imposed on 14 of the 15 patients. In the studied group, the first decompression procedure was performed on days 2 to 5 from intake, as PIA increased in evolution despite medical methods. Only 1 patient hospitalized with SAP PIA decreased by medical methods and after haemofiltration. Acute severe pancreatitis remains a serious pathology in spite of a maximum medical and surgical therapy. Continuous venous haemofiltration has contributed to lowering intraabdominal pressure. Surgery with decompression vacuum systems with negative pressure lead to a significant decrease in PIA.
C1 [Ciuntu, Bogdan Mihnea; Vasiluta, Ciprian; Georgescu, Stefan Octavian] Grigore T Popa Univ Med & Pharm, Dept Surg, Fac Med, 16 Univ Str, Iasi 700115, Romania.
   [Anton, Nicoleta; Ciuntu, Roxana] Grigore T Popa Univ Med & Pharm, Dept Ophthalmol, Fac Med, 16 Univ Str, Iasi, Romania.
   [Damian, Mihaela; Ciumanghel, Adi; Blaj, Mihaela] Grigore T Popa Univ Med & Pharm, Dept Anesthesiol & Crit Care Med, Fac Med, 16 Univ Str, Iasi 700116, Romania.
   [Azoicai, Doina] Grigore T Popa Univ Med & Pharm, Dept Prevent Med & Inderdisciplinar, Fac Med, 16 Univ Str, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy
RP Ciuntu, BM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Surg, Fac Med, 16 Univ Str, Iasi 700115, Romania.; Blaj, M (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Anesthesiol & Crit Care Med, Fac Med, 16 Univ Str, Iasi 700116, Romania.
EM bogdanmciuntu@yahoo.com; miblaj@yahoo.com
RI Anton, Nicoleta/AAT-7014-2020; Ciuntu, Bogdan/MTF-9477-2025; Ciumanghel,
   Adi Ionut/FLP-2083-2022; AZOICAI, DOINA/HDO-6161-2022; Blaj,
   Mihaela/U-6090-2017
OI Anton, Nicoleta/0000-0002-4987-5049; Ciumanghel, Adi
   Ionut/0000-0001-5457-6636; AZOICAI, DOINA/0000-0003-0423-4085; 
CR Abe R, 2010, CONTRIB NEPHROL, V166, P54, DOI 10.1159/000314852
   Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Anisia EI, 2017, REV CHIM-BUCHAREST, V68, P1598
   Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
   Badescu L, 2012, ROM BIOTECH LETT, V17, P7397
   Badescu L, 2014, J PHYSIOL BIOCHEM, V70, P355, DOI 10.1007/s13105-013-0309-9
   Badulescu O, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/169420
   Ciuntu BM, 2017, REV CHIM-BUCHAREST, V68, P1648
   De Keulenaer B, 2015, ANAESTH INTENSIVE TH, V47, P54, DOI 10.5603/AIT.a2014.0065
   DE WAELE JAN J., 2015, ANESTEZJOLOGIA INTEN, P226
   De Waele JJ, 2005, CRIT CARE, V9, pR452, DOI 10.1186/cc3754
   Endo K, 2014, SURG LAPARO ENDO PER, V24, P221, DOI 10.1097/SLE.0b013e3182937bd6
   GROSS V, 1993, HEPATO-GASTROENTEROL, V40, P522
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   Plaudis H, 2012, ANN INTENSIVE CARE, V2, DOI 10.1186/2110-5820-2-S1-S23
   Sugrue M, 2015, ANAESTH INTENSIVE TH, V47, P241, DOI 10.5603/AIT.a2015.0025
   van Brunschot S, 2014, PANCREAS, V43, P665, DOI 10.1097/MPA.0000000000000108
NR 17
TC 3
Z9 3
U1 0
U2 7
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD AUG
PY 2017
VL 68
IS 8
BP 1923
EP 1926
PG 4
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA FG5QV
UT WOS:000410388000050
DA 2026-07-24
ER
PT J
AU Armenio, A
   Cutrignelli, DA
   Nardulli, ML
   Maggio, G
   Memeo, G
   De Santis, V
   Giudice, G
   Ressa, CM
AF Armenio, Andrea
   Cutrignelli, Daniela Anna
   Nardulli, Maria Luisa
   Maggio, Giulio
   Memeo, Giuseppe
   De Santis, Valerio
   Giudice, Giuseppe
   Ressa, Cosmo Maurizio
TI Bio-Engineering tissue and VAC therapy: A new method for the treatment
   of extensive necrotizing infection in the diabetic foot
SO ANNALI ITALIANI DI CHIRURGIA
LA English
DT Article
DE Bio-Engineered Tissue; Diabetic foot; Fibroblast graft; VAC therapy
ID RANDOMIZED CONTROLLED-TRIAL; ASSISTED CLOSURE; CLINICAL-TRIAL; ULCERS;
   MULTICENTER; DERMAGRAFT; MANAGEMENT; EFFICACY; WOUNDS; STATE
AB AIM: The aim of the study is to compare the standard care for progressive necrotizing infection in diabetic foot with a treatment protocol based on the association between autologous fibroblast grafts and vacuum-assisted closure therapy (VAC).
   MATERIAL OF STUDY: A retrospective matched Case-Control study was carried out on 20 patients with diabetic foot infection, 10 treated with the standard care and 10 with our new protocol. Inclusion criteria were: acute diabetic foot necrosis (Wagner III and TO, ulcer size (30 to 80 cm2), tendon and bone exposure. Success in the treatment was evaluated as: percentage of healing at the 20th week, time of healing, deambulation, recurrence and major amputation rate.
   RESULTS: A 90% healing rate was observed after 20 weeks in the study group, compared to a 28.6% in the control group. The recurrence rate in the treated areas was 20% in the study group and 100% in the control group. None of the patients in either group required major amputations.
   DISCUSSION: We achieved very promising results by associating autologous fibroblasts grafts and V.A.C. therapy, in comparison with standard care. V.A.C. therapy seems to improve the growth rate of the fibroblasts, probably by sealing the wound and providing a moist environment following the fibroblast graft. The improved neoangiogenesis of the neo-dermis could explain the reduced recurrence rate of the study group.
   CONCLUSIONS: Despite the low number of patients involved and the retrospective nature of the analysis, this study showed a reliable, safe and cost-effective method of treating extensive infection in the diabetic foot.
C1 [Armenio, Andrea; Cutrignelli, Daniela Anna; Nardulli, Maria Luisa; De Santis, Valerio; Ressa, Cosmo Maurizio] Natl Canc Inst Giovanni Paolo II, Dept Plast & Reconstruct Surg, Viale Orazio Flacco 65, I-70124 Bari, Italy.
   [Maggio, Giulio; Memeo, Giuseppe; Giudice, Giuseppe] Univ Hosp Policlin, Dept Plast & Reconstruct Surg, Bari, Italy.
C3 IRCCS Istituto Tumori Bari Giovanni Paolo II; Universita degli Studi di
   Bari Aldo Moro
RP Cutrignelli, DA (通讯作者)，Natl Canc Inst Giovanni Paolo II, Dept Plast & Reconstruct Surg, Viale Orazio Flacco 65, I-70124 Bari, Italy.
EM daniela.cutrignelli@gmail.com
RI armenio, anea/AAI-3261-2020; /AAJ-8291-2020; Cutrignelli,
   Daniela/AAJ-8214-2020; ressa, cosmo/AAI-2285-2020
OI armenio, anea/0000-0002-7224-5176; Memeo, Giuseppe/0009-0008-6183-6684; 
CR ANDREASSI L, 1991, WOUNDS, V3, P116
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Gath HJ, 2002, PLAST RECONSTR SURG, V109, P889, DOI 10.1097/00006534-200203000-00009
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   Lipsky BA, 2004, CLIN INFECT DIS, V39, P885, DOI 10.1086/383271
   Loots MAM, 2002, EUR J CELL BIOL, V81, P153, DOI 10.1078/0171-9335-00228
   Margolis D, 2000, DIABETES CARE, V25, P1835
   Marston WA, 2003, DIABETES CARE, V26, P1701, DOI 10.2337/diacare.26.6.1701
   Oyibo SO, 2001, DIABETIC MED, V18, P133, DOI 10.1046/j.1464-5491.2001.00422.x
   Pinney E, 2000, J CELL PHYSIOL, V183, P74, DOI 10.1002/(SICI)1097-4652(200004)183:1<74::AID-JCP9>3.0.CO;2-G
   Ribu Lis, 2004, Ostomy Wound Manage, V50, P57
   Sivan U, 2014, J TISSUE ENG REGEN M
   Uccioli L, 2003, Int J Low Extrem Wounds, V2, P140, DOI 10.1177/1534734603258480
   Veves A, 2001, DIABETES CARE, V24, P290, DOI 10.2337/diacare.24.2.290
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Zimny S, 2002, J DIABETES COMPLICAT, V16, P327, DOI 10.1016/S1056-8727(01)00217-3
NR 25
TC 6
Z9 6
U1 0
U2 9
PU EDIZIONI LUIGI POZZI
PI ROME
PA VIA PANAMA 68, 00198 ROME, ITALY
SN 0003-469X
EI 2239-253X
J9 ANN ITAL CHIR
JI Ann. Ital. Chir.
PD MAY-JUN
PY 2017
VL 88
IS 3
BP 268
EP 274
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FG6EH
UT WOS:000410463400017
PM 28098565
DA 2026-07-24
ER
PT J
AU Searle, RJ
   Myers, D
AF Searle, R. J.
   Myers, D.
TI A survey of caesarean section surgical site infections with PICO™ Single
   Use Negative Pressure Wound Therapy System in high-risk patients in
   England and Ireland
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE Surgical site infections; Caesarean section; Obesity; Single-use
   negative pressure; wound therapy; Closed incisions
ID SURGERY
AB This article reports audit data from the introduction of the PICO (TM) System for caesarean section patients with high body mass index (BMI) in four hospitals in the UK and Ireland. PICO was used on closed surgical incisions following caesarean section in 399 patients with BMI >= 35 kg/m(2). Thirty-six out of 399 patients (9.0%) developed signs of surgical site infection (SSI), a rate lower than a previously reported incidence of 19.3% in a similar population. The readmission incidence was 0.8%. Therefore the use of PICO on closed surgical incisions may be associated with low incidence of SSI and readmission in this high-risk group. (C) 2017 Published by Elsevier Ltd on behalf of The Healthcare Infection Society.
C1 [Searle, R. J.; Myers, D.] Smith & Nephew Adv Wound Management, Kingston Upon Hull, N Humberside, England.
C3 Smith & Nephew
RP Searle, RJ (通讯作者)，Smith & Nephew, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM richard.searle@smith-nephew.com
FU Smith Nephew
FX This work was supported by Smith & Nephew.
CR Betrán AP, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148343
   De Vries FEE, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004673
   Health and Social Care Information Centre, 2015, NHS MAT STAT ENGL 20, P2013
   Health Survey for England, AD OB OV
   Karlakki S, 2013, BONE JOINT RES, V2, P276, DOI 10.1302/2046-3758.212.2000190
   National Institute for Health and Care Excellence, 2013, NICE SUPP COMM SURG
   NHS choices, CAES SECT
   Panda S, 2016, British Journal of Midwifery, V24, P322, DOI [10.12968/bjom.2016.24.5.322, 10.12968/bjom.2016.24.5.322, DOI 10.12968/BJOM.2016.24.5.322]
   Sebire NJ, 2001, INT J OBESITY, V25, P1175, DOI 10.1038/sj.ijo.0801670
   Wloch C, 2012, BJOG-INT J OBSTET GY, V119, P1324, DOI 10.1111/j.1471-0528.2012.03452.x
NR 10
TC 8
Z9 9
U1 0
U2 1
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD OCT
PY 2017
VL 97
IS 2
BP 122
EP 124
DI 10.1016/j.jhin.2017.02.023
PG 3
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA FG6TC
UT WOS:000410522300003
PM 28807639
DA 2026-07-24
ER
PT J
AU Chen, L
   Li, GR
   Liu, S
   Ma, XJ
   Li, XY
   Su, YJ
   Guo, SZ
AF Chen, Lin
   Li, Guorui
   Liu, Sha
   Ma, Xianjie
   Li, Xueyong
   Su, Yingjun
   Guo, Shuzhong
TI Comparison of Negative Pressure Wound Therapy and Conventional Therapy
   for Cranial Bone-exposed Wounds in Rabbits
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE cranial bone-exposed wound; negative pressure wound therapy; periosteum;
   wound healing
ID VACUUM-ASSISTED CLOSURE; TISSUE BLAST INJURY; MICROVESSEL DENSITY; SWINE
   MODEL; EXPRESSION; PERIOSTEUM; FRACTURES; DEFECTS; FLAPS
AB Background: Bone-exposed wounds with intact or defected periosteum are difficult to heal. To provide relevant experimental evidence for guidance of clinical therapy, we established a rabbit model to compare the efficacies of negative pressure wound therapy (NPWT) and conventional guaze dressing therapy on the healing of cranial bone-exposed wounds.
   Methods: Full-thickness excisional circular wounds of 2.0 cm in diameter with exposed bones covered with or without periosteum were created at the parietal regions in 88 rabbits that were further randomly divided into the following treatment groups: periosteum-intact wounds treated with conventional vaseline gauze dressings (P + Control group), periosteum-intact wounds treated with NPWT (P + NPWT group), periosteum-lacking wounds treated with conventional vaseline gauze dressings (P-Control group), and periosteum-lacking wounds treated with NPWT (P-NPWT group). The wounds of NPWT groups were treated using a negative pressure therapy assembly that was set at a continuous pressure of -125 mm Hg for 7 days, then covered with vaseline gauze. The wound healing rates, wound infection rates, hydroxyproline content, and wound tissue histology were determined and evaluated.
   Results: The NPWT shortened the wound healing time by approximately 5 days when compared with the conventional gauze therapy. The histological characterization of wound tissues showed that NPWT decreased the inflammatory cells infiltration, accelerated reepithelialization and facilitated the organization of collagen fibers into neat layers on postoperative day (POD) 10. The NPWT enhanced bacterial clearances, reduced infection rates and increased the hydroxyproline contents in both types of wounds on PODs 10 and 15. The immunohistochemical staining of CD31 showed the NPWT treatment resulted in a significantly increased and persistent angiogenesis, and the wounds treated with NPWT showed well developed and more functional vessels at POD 7 compared with control.
   Conclusions: The NPWT is a more effective therapy for bone-exposed wounds than conventional guaze dressing therapy. The NPWT can promote bone-exposed wounds healing by increasing collagen contents and vessels densities while reducing inflammatory cells infiltration, reducing wound infection rates, and inducing an ordered collagen arrangement.
C1 [Chen, Lin; Li, Guorui; Liu, Sha; Ma, Xianjie; Su, Yingjun; Guo, Shuzhong] Fourth Mil Med Univ, Xijing Hosp, Dept Plast & Reconstruct Surg, 15 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
   [Li, Guorui] Chinese Peoples Liberat Army, Hosp 25, Dept Burns & Plast Surg, Xian, Shaanxi, Peoples R China.
   [Li, Xueyong] Fourth Mil Med Univ, Tangdu Hosp, Dept Plast Surg, Xian, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Su, YJ; Guo, SZ (通讯作者)，Fourth Mil Med Univ, Xijing Hosp, Dept Plast & Reconstruct Surg, 15 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
EM xjzxwka@fmmu.edu.cn; xjzxwkb@fmmu.edu.cn
RI Chen, Lin/JKH-5087-2023; /AAI-1694-2020
OI Chen, Lin/0000-0002-0586-7098; 
FU Shaanxi Provincial Science and Technology Innovation Project
   [2015KTTSGY01-06]; Clinical Innovative Technique Grant of PLA
   [2010gxjs079]
FX This study was supported by Shaanxi Provincial Science and Technology
   Innovation Project (2015KTTSGY01-06) and Clinical Innovative Technique
   Grant of PLA (2010gxjs079).
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NR 43
TC 7
Z9 7
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2017
VL 79
IS 4
BP 397
EP 403
DI 10.1097/SAP.0000000000001074
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FG8DU
UT WOS:000410659400017
PM 28816717
DA 2026-07-24
ER
PT J
AU Fankhauser, CD
   Hermanns, T
   Hasse, B
   Rancic, Z
AF Fankhauser, Christian Daniel
   Hermanns, Thomas
   Hasse, Barbara
   Rancic, Zoran
TI Excessive Wound Fluid Discharge during Retroperitoneal Negative Pressure
   Wound Therapy
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID INFECTIONS; GRAFT
AB We report a case of a 66-year-old man with an excessive wound fluid discharge during negative pressure wound therapy (NPWT) in the retroperitoneal space. Creatinine concentration of the unclear fluid and a subsequent late-phase computed tomography confirmed the diagnosis of a urinary fistula. NPWT was terminated, and the patient was successfully treated with a nephrostomy combined with a retrograde double J stent and a Foley catheter.
C1 [Fankhauser, Christian Daniel; Hermanns, Thomas] Univ Zurich, Univ Hosp, Dept Urol, Zurich, Switzerland.
   [Hasse, Barbara] Univ Zurich, Univ Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland.
   [Rancic, Zoran] Univ Zurich, Univ Hosp, Dept Vasc Surg, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital; University of Zurich; University Zurich
   Hospital
RP Fankhauser, CD (通讯作者)，Frauenklin Str 10, CH-8032 Zurich, Switzerland.
EM christian.fankhauser@usz.ch
RI Fankhauser, Christian/I-4672-2017; Hasse, Barbara/T-1054-2017
OI Hasse, Barbara/0000-0001-7196-3734
CR Ducasse E, 2004, ANN VASC SURG, V18, P521, DOI 10.1007/s10016-004-0075-9
   Gutowski P, 1998, Ann Acad Med Stetin, VSuppl 41, P1
   Hasse B, 2013, SWISS MED WKLY, V143, DOI 10.4414/smw.2013.13754
   Mayer D, 2011, ANN SURG, V254, P754, DOI 10.1097/SLA.0b013e3182365864
   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
NR 5
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD AUG
PY 2017
VL 43
AR 314.e1
DI 10.1016/j.avsg.2017.02.017
PG 3
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA FG8SH
UT WOS:000410706700053
PM 28479439
DA 2026-07-24
ER
PT J
AU Burkhart, RA
   Javed, AA
   Ronnekleiv-Kelly, S
   Wright, MJ
   Poruk, KE
   Eckhauser, F
   Makary, MA
   Cameron, JL
   Wolfgang, CL
   He, J
   Weiss, MJ
AF Burkhart, Richard A.
   Javed, Ammar A.
   Ronnekleiv-Kelly, Sean
   Wright, Michael J.
   Poruk, Katherine E.
   Eckhauser, Frederic
   Makary, Martin A.
   Cameron, John L.
   Wolfgang, Christopher L.
   He, Jin
   Weiss, Matthew J.
TI The use of negative pressure wound therapy to prevent post-operative
   surgical site infections following pancreaticoduodenectomy
SO HPB
LA English
DT Article
ID PREOPERATIVE BILIARY DRAINAGE; PANCREATIC-CANCER; ADJUVANT CHEMOTHERAPY;
   COMPLICATIONS; OUTCOMES; FAILURE; FISTULA; SURGERY; BURDEN; HERNIA
AB Background: Rates of superficial surgical site infection (SSI) following pancreaticoduodenectomy remain high. Following resection for cancer, complications such as SSI impact adjuvant therapy delivery and portend worse survival. An incisional negative pressure dressing (iVAC) has been demonstrated to reduce SSI in other high-risk cohorts.
   Methods: Following a comprehensive effort to identify patients at high risk for SSI, the practice patterns at a single academic center shifted and iVAC use increased. SSI rates were tracked in a prospectively maintained database and are reported.
   Results: 394 patients underwent pancreaticoduodenectomy over 21 months. 120 patients (30.5%) had an iVAC applied. The overall rate of SSI was 19.8%. On multivariate analysis, increased risk for SSI was associated with neoadjuvant therapy, preoperative biliary interventions and prior abdominal surgery. iVAC use decreased the rate of SSI (OR 0.45, p = 0.015). In the highest-risk patients, SSI rate declined from 50% in patients without an iVAC to 19.1% with iVAC use (p = 0.015).
   Conclusion: The use of an iVAC following pancreaticoduodenectomy is associated with decreased SSI rates. This is particularly true for patients at highest risk as defined by a previously established risk scoring system in patients undergoing open pancreaticoduodenectomy.
C1 [Burkhart, Richard A.; Javed, Ammar A.; Ronnekleiv-Kelly, Sean; Wright, Michael J.; Poruk, Katherine E.; Eckhauser, Frederic; Makary, Martin A.; Cameron, John L.; Wolfgang, Christopher L.; He, Jin; Weiss, Matthew J.] Johns Hopkins Univ Hosp, Dept Surg, Halsted 608,600 N Wolfe St, Baltimore, MD 21287 USA.
C3 Johns Hopkins University; Johns Hopkins Medicine
RP Weiss, MJ (通讯作者)，Johns Hopkins Univ Hosp, Dept Surg, Halsted 608,600 N Wolfe St, Baltimore, MD 21287 USA.
EM mweiss5@jhmi.edu
RI Wolfgang, Christopher/HGD-0863-2022; Javed, Ammar/AAE-2870-2020
OI Wright, Michael/0000-0003-3353-6664; He, Jin/0000-0001-9149-2247; Javed,
   Ammar/0000-0002-5463-5250
FU NIH [5T32CA126607-08]; Drs. Keith and Valda Kaye Research Fund
FX Funding for this study was in part provided by NIH grant 5T32CA126607-08
   (RAB). It is also with deep appreciation that these authors wish to
   thank the Drs. Keith and Valda Kaye Research Fund.
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NR 28
TC 43
Z9 46
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1365-182X
EI 1477-2574
J9 HPB
JI HPB
PD SEP
PY 2017
VL 19
IS 9
BP 825
EP 831
DI 10.1016/j.hpb.2017.05.004
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA FG9VQ
UT WOS:000410788400011
PM 28602643
OA Bronze
DA 2026-07-24
ER
PT J
AU Ugurlar, M
   Sönmez, MM
   Armagan, R
   Eren, OT
AF Ugurlar, Meric
   Sonmez, Mesut Mehmet
   Armagan, Raffi
   Eren, Osman Tugrul
TI Comparison of two different vacuum-assisted closure (VAC) treatments of
   multiple chronic diabetic foot wounds in the same extremity
SO FOOT AND ANKLE SURGERY
LA English
DT Article
DE Y-connector; Bridge-VAC; Diabetic foot; Chronic wound
ID RANDOMIZED CONTROLLED-TRIAL; LEG ULCERS; THERAPY; FOUNDATION;
   MANAGEMENT; AMPUTATION; DRESSINGS; INJURIES; STATE
AB Background: The aim of the present study is to compare the clinical efficacy and safety of two different vacuum-assisted closure (VAC) applications in one center between two groups of patients with Wagner Grade 3-4 multiple chronic diabetic foot wounds.
   Methods: The study was a randomized-controlled, prospective investigation between two groups of patients with Wagner Grade 3-4 multiple chronic diabetic foot wounds at single extremity. There were 10 patients in the first group receiving VAC treatment by means of Y-connector and 11 patients in the second group receiving bridge-VAC treatment.
   Results: There were no significant difference in Revised Foot Function Index scores and total treatment costs between the both groups. The cost of the VAC dressing supplies in one session of the dressings was lower in the bridge-VAC group.
   Conclusions: In conclusion, although bridge-VAC treatment seems to be an alternative method to the VAC treatment by means of Y-connector, we found no superiority of one over the other VAC application for chronic diabetic foot wounds. (C) 2016 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
C1 [Ugurlar, Meric; Sonmez, Mesut Mehmet; Armagan, Raffi; Eren, Osman Tugrul] Sisli Hamidiye Etfal Educ & Res Hosp, Dept Orthopaed & Traumatol, Istanbul, Turkey.
C3 Istanbul Sisli Hamidiye Etfal Training & Research Hospital
RP Ugurlar, M (通讯作者)，Sisli Hamidiye Etfal Egitim & Arastirma Hastanesi, TR-34371 Istanbul, Turkey.
EM mugurlar@yahoo.com; mdmesutsonmez@yahoo.com; raffiarmagan@gmail.com;
   tugruleren@hotmail.com
RI Uğurlar, Meriç/M-1784-2016; eren, osman/HIK-2394-2022; Armagan,
   Raffi/GPS-4921-2022
OI Uğurlar, Meriç/0000-0003-0145-6272; 
CR Aksakal IA, 2014, J HAND SURG-AM, V39, P1022, DOI 10.1016/j.jhsa.2014.02.016
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   Etöz A, 2004, WOUNDS, V16, P264
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NR 26
TC 5
Z9 8
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1268-7731
EI 1460-9584
J9 FOOT ANKLE SURG
JI Foot Ankle Surg.
PD SEP
PY 2017
VL 23
IS 3
BP 173
EP 178
DI 10.1016/j.fas.2016.05.314
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA FH1UA
UT WOS:000410923900009
PM 28865586
DA 2026-07-24
ER
PT J
AU Lee, YJ
   Park, MC
   Park, DH
   Hahn, HM
   Kim, SM
   Lee, IJ
AF Lee, Yoo Jung
   Park, Myong Chul
   Park, Dong Ha
   Hahn, Hyung Min
   Kim, Sue Min
   Lee, Il Jae
TI Effectiveness of Acellular Dermal Matrix on Autologous Split-Thickness
   Skin Graft in Treatment of Deep Tissue Defect: Esthetic Subjective and
   Objective Evaluation
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Acellular dermal matrix; Skin graft; Vancouver Scar Scale; Patient and
   Observer Scar Assessment Scale; Negative-pressure wound therapy
ID FLAP DONOR-SITE; TOPICAL NEGATIVE-PRESSURE; VACUUM-ASSISTED CLOSURE;
   RECONSTRUCTIVE SURGERY; THIGH FLAP; CLINICAL-TRIAL; ACUTE BURNS;
   FOLLOW-UP; SUBSTITUTION; MANAGEMENT
AB A split-thickness skin graft (STSG) is performed to cover a large full-thickness skin defect. Esthetic and functional deficits can result, and many studies have sought to overcome them. This study compared the effectiveness of the acellular dermal matrix (ADM) graft and STSG concerning esthetic and functional effectiveness of ADM on scar quality.
   Of the patients who underwent anterolateral thigh free flap from 2011 to 2015, patients who received skin graft only (n = 10) or skin graft with ADM (n = 20) for coverage of the donor site were enrolled. In all cases, autologous STSG was performed with 1:1.5 meshed 0.008-0.010-inch-thick skin. In the skin graft with ADM group, 0.008-0.013-inch-thick meshed ADM (CGderm(A (R)); CGBio, Inc., Seungnam, Korea) was co-grafted. Negative-pressure wound therapy (CuraVAC(A (R)); CGBio, Inc., Seungnam, Korea) was applied to both groups in continuous mode at -120 mmHg. We investigate early outcomes (skin loss rate, duration of negative-pressure wound therapy, days to removal of stitches, days to achieve complete healing, and complications) and late outcomes in terms of scar quality (vascularity, pigmentation, pliability and height) and graft-related symptoms (itching sensation and pain). Assessments used the Vancouver Scar Scale and the Patient and Observer Scar Assessment Scale. Skin fold was measured to evaluate the elasticity of scar tissue.
   In the Vancouver Scar Scale, vascularity subscore (p = 0.003) and total score (p = 0.016) were significantly lower in the skin graft with ADM group. In Patient and Observer Scar Assessment Scale, the pain (p = 0.037) and stiffness subscores (p = 0.002), and total score (p = 0.017) were significantly lower in the skin graft with ADM group.
   Skin graft with ADM results in better scar quality in objective and subjective aspects.
C1 [Lee, Yoo Jung; Park, Myong Chul; Park, Dong Ha; Hahn, Hyung Min; Kim, Sue Min; Lee, Il Jae] Ajou Univ, Dept Plast & Reconstruct Surg, Sch Med, Worldcup Ro 164, Suwon 443721, Gyeonggi Do, South Korea.
C3 Ajou University
RP Lee, IJ (通讯作者)，Ajou Univ, Dept Plast & Reconstruct Surg, Sch Med, Worldcup Ro 164, Suwon 443721, Gyeonggi Do, South Korea.
EM i00325@live.co.kr
CR Andrews BT, 2006, LARYNGOSCOPE, V116, P1918, DOI 10.1097/01.mlg.0000235935.07261.98
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NR 24
TC 25
Z9 27
U1 3
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD OCT
PY 2017
VL 41
IS 5
BP 1049
EP 1057
DI 10.1007/s00266-017-0891-2
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FH5FC
UT WOS:000411189300010
PM 28526905
DA 2026-07-24
ER
PT J
AU Loftus, TJ
   Jordan, JR
   Croft, CA
   Smith, RS
   Efron, PA
   Moore, FA
   Mohr, AM
   Brakenridge, SC
AF Loftus, Tyler J.
   Jordan, Janeen R.
   Croft, Chasen A.
   Smith, R. Stephen
   Efron, Philip A.
   Moore, Frederick A.
   Mohr, Alicia M.
   Brakenridge, Scott C.
TI Characterization of hypoalbuminemia following temporary abdominal
   closure
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Albumin; hypoalbuminemia; open abdomen; primary fascial closure;
   temporary abdominal closure
ID OPEN ABDOMEN; NUTRITION SUPPORT; SYSTEMIC INFLAMMATION; INJURY; SEPSIS;
   TRAUMA; MANAGEMENT; ALBUMIN; SHOCK; THERAPY
AB BACKGROUND: The purpose of this study was to characterize associations among serum proteins, negative-pressure wound therapy (NPWT) fluid loss, and primary fascial closure (PFC) following emergent laparotomy and temporary abdominal closure (TAC). We hypothesized that high levels of C-reactive protein (CRP) and NPWT output would be associated with hypoalbuminemia and failure to achieve PFC.
   METHODS: We performed a retrospective analysis of 233 patients managed with NPWT TAC. Serum proteins and resuscitation indices were assessed on admission, initial laparotomy, and then at 48 hours, 96 hours, 7 days, and discharge. Correlations were assessed by Pearson coefficient. Multivariable regression was performed to identify predictors of PFC with cutoff values for continuous variables determined by Youden index.
   RESULTS: Patients who failed to achieve PFC (n = 55) had significantly higher CRP at admission (249 vs. 148 mg/L, p = 0.003), initial laparotomy (237 vs. 154, p = 0.002), and discharge (124 vs. 72, p = 0.003), as well as significantly lower serumalbumin at 7 days (2.3 vs. 2.5 g/dL, p = 0.028) and discharge (2.5 vs. 2.8, p = 0.004). Prealbumin (in milligrams per deciliter) was similar between groups at each time point. There was an inverse correlation between nadir serum albumin and total milliliters of NPWT output (r = -0.33, p < 0.001). Exogenous albumin administration (in grams per day) correlated with higher serum albumin levels at each time point: 48 hours: r = 0.26 (p = 0.002), 96 hours: r = 0.29 (p = 0.002), 7 days: r = 0.40 (p < 0.001). Albumin of less than 2.6 g/dL was an independent predictor of failure to achieve PFC (odds ratio, 2.59; 95% confidence interval, 1.02-6.61) in a multivariate model including abdominal sepsis, body mass index of greater than 40 kg/m(2), and CRP of greater than 250 mg/L.
   CONCLUSIONS: Early and persistent systemic inflammation and high NPWT output were associated with hypoalbuminemia, which was an independent predictor of failure to achieve PFC. The utility of exogenous albumin following TAC requires further study. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
C1 Univ Florida Hlth, Dept Surg, Gainesville, FL 32610 USA.
   Univ Florida Hlth, Sepsis & Crit Illness Res Ctr, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Brakenridge, SC (通讯作者)，Univ Florida Hlth, 1600 SW Archer Rd,Room M-602, Gainesville, FL 32610 USA.
EM Scott.Brakenridge@surgery.ufl.edu
RI Brakenridge, Scott/AAD-6691-2019; Mohr, Alicia/E-3016-2015; Loftus,
   Tyler/J-7761-2016
OI Brakenridge, Scott/0000-0002-7327-3718; Mohr,
   Alicia/0000-0003-1732-1313; Loftus, Tyler/0000-0001-5354-443X; Smith,
   Robert/0000-0002-0455-6415
FU National Institute of General Medical Sciences (NIGMS) [R01
   GM105893-01A1, R01 GM113945-01, P50 GM111152-01]; NIGMS [T32GM-08721];
   National Institute of General Medical Sciences [R01GM105893,
   T32GM008721] Funding Source: NIH RePORTER; National Institute on Aging
   [P30AG028740] Funding Source: NIH RePORTER
FX The authors were supported in part by grants R01 GM105893-01A1 (A.M.
   M.), R01 GM113945-01 (P.A.E.), and P50 GM111152-01 (S.C.B., P.A.E., F.A.
   M., A.M.M.) awarded by the National Institute of General Medical
   Sciences (NIGMS). T.J.L. was supported by a postgraduate training grant
   (T32GM-08721) in burns, trauma, and perioperative injury by NIGMS.
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NR 46
TC 8
Z9 9
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD OCT
PY 2017
VL 83
IS 4
BP 650
EP 656
DI 10.1097/TA.0000000000001553
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA FH8PN
UT WOS:000411460500013
PM 28837537
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Strugala, V
   Martin, R
AF Strugala, Vicki
   Martin, Robin
TI Meta-Analysis of Comparative Trials Evaluating a Prophylactic Single-Use
   Negative Pressure Wound Therapy System for the Prevention of Surgical
   Site Complications
SO SURGICAL INFECTIONS
LA English
DT Article
DE postoperative complication; prophylaxis; surgical site infection; wound
   infection; wound management
ID RANDOMIZED CONTROLLED-TRIAL; PRIMARY HIP; SURGERY; INFECTION; INCISION;
   CLOSURE; CARE; DEHISCENCE; REDUCTION; DRESSINGS
AB Background: We report the first meta-analysis on the impact of prophylactic use of a specific design of negative pressure wound therapy (NPWT) device on surgical site complications.
   Methods: Articles were identified in which the specific single-use NPWT device (PICO, Smith & Nephew) was compared with standard care for surgical site infection (SSI), dehiscence, or length of stay (LOS). Risk ratio (RR) 95% confidence interval (CI) (SSI; dehiscence) or mean difference in LOS 95% CI was calculated using RevMan v5.3.
   Results: There were 1863 patients (2202 incisions) represented by 16 articles. Among 10 randomized studies, there was a significant reduction in SSI rate of 51% from 9.7% to 4.8% with NPWT intervention (RR 0.49 [95% CI 0.34-0.69] p<0.0001). There were six observational studies assessing reduction in SSI rate of 67% from 22.5% to 7.4% with NPWT (RR 0. 32 [95% CI 0.18-0.55] p<0.0001). Combining all 16 studies, there was a significant reduction in SSI of 58% from 12.5% to 5.2% with NPWT (RR 0.43 [95% CI 0.32-0.57] p<0.0001). Similar effects were seen irrespective of the kind of surgery (orthopedic, abdominal, colorectal, or cesarean section), although the numbers needed to treat (NNT) were lower in operations with higher frequencies of complications. There was a significant reduction in dehiscence from 17.4% to 12.8% with NPWT (RR 0.71 [95% CI 0.54-0.92] p<0.01). The mean reduction in hospital LOS by NPWT was also significant (-0.47 days [95% CI -0.71 to -0.23] p<0.0001).
   Conclusions: The significant reduction in SSI, wound dehiscence, and LOS on the basis of pooled data from 16 studies shows a benefit of the PICO single-use NPWT system compared with standard care in closed surgical incisions.
C1 [Strugala, Vicki; Martin, Robin] Smith & Nephew Plc, Adv Wound Management Clin Sci & Med Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
RP Martin, R (通讯作者)，Smith & Nephew Plc, Adv Wound Management Clin Sci & Med Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM robin.martin@smith-nephew.com
RI strugala, vicki/JEZ-4021-2023
OI Martin, Robin/0000-0002-9314-0437
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NR 53
TC 102
Z9 131
U1 0
U2 13
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD OCT
PY 2017
VL 18
IS 7
BP 810
EP 819
DI 10.1089/sur.2017.156
PG 10
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA FI3CP
UT WOS:000411834300009
PM 28885895
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Wang, CY
   Chiao, HY
   Chou, CY
   Wu, CJ
   Chang, CK
   Chu, TS
   Dai, NT
AF Wang, Chi-Yu
   Chiao, Hao-Yu
   Chou, Chang-Yi
   Wu, Chien-Ju
   Chang, Chun-Kai
   Chu, Tzi-Shiang
   Dai, Niann-Tzyy
TI Successful salvage and reconstruction of a finger threatened by
   Vibrio vulnificus necrotising fasciitis using fenestrated-type
   artificial dermis and three steps of topical negative pressure wound
   therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Artificial dermis; Compartment syndrome; Necrotising fasciitis; NPWT;
   Vibrio vulnificus
ID SKIN-GRAFT; INFECTIONS
AB Vibrio vulnificus can cause severe skin and soft tissue infection (SSTI). The pathogen is an opportunistic marine bacterium that is likely to infect patients with chronic liver disease, patients in an immunocompromised state, and those in end-stage renal disease. V. vulnificus gains entry through soft tissues by direct penetration of a wound by infected marine organisms, such as raw oysters, shellfish and other seafood, or by exposing a wound to contaminated water. Despite its ease of entry, V. vulnificus necrotising fasciitis with compartment syndrome has rarely been described. We report a case of an elderly patient with end-stage renal disease undergoing haemodialysis, who developed necrotising fasciitis following infection by V. vulnificus through a puncture injury while cleaning fish. A successful salvage and reconstruction surgery was performed using fenestrated-type artificial dermis followed by negative pressure wound therapy. This case presents a reasonable treatment option for threatening V. vulnificus necrotising fasciitis with compartment syndrome.
C1 [Wang, Chi-Yu; Chiao, Hao-Yu; Chou, Chang-Yi; Wu, Chien-Ju; Chang, Chun-Kai; Chu, Tzi-Shiang; Dai, Niann-Tzyy] Triserv Gen Hosp, Div Plast & Reconstruct Surg, Dept Surg, Natl Def Med Ctr, Taipei, Taiwan.
   [Wang, Chi-Yu] Kaohsiung Armed Forces Gen Hosp, Div Plast & Reconstruct Surg, Dept Surg, Kaohsiung, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical University
RP Dai, NT (通讯作者)，Triserv Gen Hosp, Plast & Reconstruct Surg, Natl Def Med Ctr, 325 Cheng Kung Rd,Sec 2, Taipei 114, Taiwan.
EM niantzyydai@gmail.com
RI Chiao, Hao Yu/HLX-2170-2023
OI Chiao, Hao-Yu/0000-0001-5157-634X
CR Baldwin C, 2009, ANN PLAS SURG, V62, P92, DOI 10.1097/SAP.0b013e31817762fd
   Centers for Disease Control and Prevention (CDC), 2005, MMWR Morb Mortal Wkly Rep, V54, P928
   Fraccalvieri M, 2012, INT WOUND J, V9, P214, DOI 10.1111/j.1742-481X.2011.00878.x
   Huang KC, 2008, J INFECTION, V57, P290, DOI 10.1016/j.jinf.2008.07.009
   Lim PL, 2005, ANN ACAD MED SINGAP, V34, P582
   Petkar KS, 2011, BURNS, V37, P925, DOI 10.1016/j.burns.2011.05.013
   Potter MJ, 2008, BURNS, V34, P164, DOI 10.1016/j.burns.2007.06.020
   Waltzman JT, 2014, J BURN CARE RES, V35, pE338, DOI 10.1097/BCR.0000000000000009
   Wong CH, 2004, CRIT CARE MED, V32, P1535, DOI 10.1097/01.CCM.0000129486.35458.7D
   Wong Chin-Ho, 2005, Curr Opin Infect Dis, V18, P101, DOI 10.1097/01.qco.0000160896.74492.ea
NR 10
TC 4
Z9 6
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2017
VL 14
IS 5
BP 818
EP 822
DI 10.1111/iwj.12711
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FI3ME
UT WOS:000411865700012
PM 28052529
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Téot, L
   Boissiere, F
   Fluieraru, S
AF Teot, Luc
   Boissiere, Florian
   Fluieraru, Sergiu
TI Novel foam dressing using negative pressure wound therapy with
   instillation to remove thick exudate
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Devitalised tissue; Fibrinous tissue; Instillation; Negative pressure
   wound therapy; Wound cleansing
ID SYSTEM; SALINE; CARE
AB We describe our experience with a novel foam dressing architecture in tandem with negative pressure wound therapy and instillation (NPWTi-d) for removing viscous wound exudate and infectious materials. A retrospective review was conducted of the outcomes of 21 patients who received NPWTi-d using a reticulated open cell foam instillation dressing with through holes (ROCF-CC) designed to facilitate the removal of thick wound exudate and infectious materials. NPWTi-d with ROCF-CC was used to treat large complex chronic wounds with viscous wound exudate that contained substantial areas of devitalised tissue. Debridement was performed as appropriate or available. NPWTi-d with ROCF-CC assisted in loosening, solubilising and detaching viscous exudate, dry fibrin, wet slough and other infectious materials. Percent surface area of black non-viable tissue and yellow fibrinous slough was reduced to10% in 18/21 (857%) and 12/21 (571%) wounds, respectively, after an average of 1-3 applications (3-9 days) of NPWTi-d with ROCF-CC. Preliminary evidence suggests that adjunctive use of NPWTi-d with ROCF-CC may help clean large, complex wounds when complete surgical debridement is not possible or appropriate and/or when areas of slough and non-viable tissue remain present on the wound surface.
C1 [Teot, Luc; Boissiere, Florian; Fluieraru, Sergiu] Montpellier Univ Hosp, Dept Wound Healing, Burns Unit Plast Surg, 395 Ave Doeyn Giraud, F-34295 Montpellier, France.
C3 Universite de Montpellier; CHU de Montpellier
RP Téot, L (通讯作者)，Montpellier Univ Hosp, Dept Wound Healing, Burns Unit Plast Surg, 395 Ave Doeyn Giraud, F-34295 Montpellier, France.
EM l-teot@chu-montpellier.fr
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 17
TC 68
Z9 86
U1 2
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2017
VL 14
IS 5
BP 842
EP 848
DI 10.1111/iwj.12719
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FI3ME
UT WOS:000411865700016
PM 28244217
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Chen, XJ
   Liu, S
   Gao, GZ
   Yan, DX
   Jiang, WS
AF Chen, X. J.
   Liu, S.
   Gao, G. Z.
   Yan, D. X.
   Jiang, W. S.
TI Effects of vacuum sealing drainage on the treatment of cranial
   bone-exposed wounds in rabbits
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Cranial bone-exposed wound; Vacuum sealing drainage; Periosteum; Wound
   healing; Efficacy
ID NEGATIVE-PRESSURE THERAPY; FREE-FLAP TRANSPLANTATION; MICROVESSEL
   DENSITY; REPAIR
AB This study was designed to assess the efficacy of vacuum sealing drainage (VSD) on skull exposure wounds in rabbits and to investigate the underlying mechanism of the process. Full-thickness excisional circular wounds 2 x 2 cm with or without periosteum involvement were created in 88 New Zealand white rabbits (mean body weight: 3.0 +/- 0.65 kg). Animals were randomly divided into 4 groups: periosteum-intact wounds treated with traditional dressing (p+control), periosteum-intact wounds treated with VSD (p+VSD), periosteum-lacking wounds treated with traditional dressing (p-control) and periosteum-lacking wounds treated with VSD (p-VSD). The wounds treated with traditional dressing were covered with Vaseline gauze, while VSD treatment was accompanied with continuous -120 mmHg pressure. Finally, wound tissues were harvested for analysis of hydroxyproline content and histologic detection. VSD hastened the wound healing process significantly (P<0.05) compared to the corresponding control groups. VSD alleviated the inflammation reaction, accelerated re-epithelialization and facilitated the organization of collagen fibers into neat rows. During the wound healing process, the hydroxyproline content increased overtime [i.e., postoperative days (POD) 7, POD 10 and POD 15] in all four groups, and it peaked in the p+VSD group. VSD also promoted angiogenesis via increasing number and quality of collagen. We concluded that VSD can promote healing in bone-exposed wounds via increasing hydroxyproline content and vessel density, reducing inflammatory responses and generating ordered collagen arrangement.
C1 [Chen, X. J.; Liu, S.; Gao, G. Z.; Yan, D. X.; Jiang, W. S.] 253rd Hosp Peoples Liberat Army, Dept Burn & Plast Surg, Hohhot, Inner Mongolia, Peoples R China.
RP Chen, XJ (通讯作者)，253rd Hosp Peoples Liberat Army, Dept Burn & Plast Surg, Hohhot, Inner Mongolia, Peoples R China.
EM hhaolijun@163.com
RI Gao, Guozhen/MBG-9837-2025
FU Army Medical and Health Care Research Fund [CBJ15J007]
FX This study is supported by Army Medical and Health Care Research Fund
   (No. CBJ15J007).
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NR 21
TC 6
Z9 9
U1 0
U2 9
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1678-4510
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2017
VL 50
IS 12
AR e5837
DI 10.1590/1414-431X20175837
PG 7
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA FI4JD
UT WOS:000411936400001
PM 28977118
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Mattox, EA
AF Mattox, Elizabeth Andersson
TI Reducing Risks Associated With Negative-Pressure Wound Therapy:
   Strategies for Clinical Practice
SO CRITICAL CARE NURSE
LA English
DT Article
ID EVIDENCE-BASED RECOMMENDATIONS; SURGICAL SITE INFECTION; COST; SURGERY;
   STEPS; FOAM
AB Negative-pressure wound therapy represents a relatively new strategy for wound management. Significant, life-threatening complications (bleeding, infection, and retained dressing material) have been associated with negative-pressure wound therapy. As a result, the Food and Drug Administration published several warnings to negative-pressure wound therapy users and recommended that clinicians ordering, managing, and/or monitoring negative-pressure wound therapy be aware of the potential complications and be prepared to take prompt action to reduce patients' risk for harm. This article reviews and organizes published consensus, expert opinion, research, and manufacturer guidelines about patient safety during negative-pressure wound therapy relevant to nurses practicing in acute and critical care settings, including in advanced practice roles. (Critical Care Nurse. 2017; 37[ 5]: 67-77)
C1 [Mattox, Elizabeth Andersson] VA Puget Sound Hlth Care Syst, Pulm & Crit Care Med Sect, Seattle, WA 98108 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System
RP Mattox, EA (通讯作者)，VA Puget Sound Hlth Care Syst, 1660 S Columbian Way, Seattle, WA 98108 USA.
EM eamattox@gmail.com
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NR 67
TC 14
Z9 17
U1 0
U2 12
PU AMER ASSOC CRITICAL CARE NURSES
PI ALISO VIEJO
PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA
SN 0279-5442
EI 1940-8250
J9 CRIT CARE NURSE
JI Crit. Care Nurse
PD OCT
PY 2017
VL 37
IS 5
BP 67
EP 77
DI 10.4037/ccn2017308
PG 11
WC Critical Care Medicine; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Nursing
GA FI9YI
UT WOS:000412365200007
PM 28966197
DA 2026-07-24
ER
PT J
AU Kaushik, D
   Joshi, N
   Kumar, R
   Gaba, S
   Sapra, R
   Kumar, K
AF Kaushik, D.
   Joshi, N.
   Kumar, R.
   Gaba, S.
   Sapra, R.
   Kumar, K.
TI Negative pressure wound therapy versus gauze dressings for the treatment
   of contaminated traumatic wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE high energy; soft tissue trauma; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; SOFT-TISSUE
   INJURIES; OPEN FRACTURES; CLINICAL-EXPERIENCE; MANAGEMENT; INFECTION;
   COVERAGE; TIBIA
AB Objective: This compares hospital suction negative pressure wound therapy (NPWT) with conventional gauze dressings in traumatic soft-tissue injury at a tertiary care centre.
   Methods: A prospective control study was conducted between September 2012 and November 2014. Patients with one or more traumatic soft-tissue injuries with contaminated wounds were allocated to either a test group (received NPWT) or control group (received conventional gauze). Wounds were assessed by two orthopaedic surgeons. If grade A was achieved, the wound was covered with split-thickness skin graft, flap or delayed primary closure; otherwise, revision debridement and NPWT/saline gauze dressings were applied. Descriptive statistics (mean, standard deviation and proportions) were used to summarise the study variables. The 95% confidence intervals (CI) for difference of mean were used. Chi-square test and Fisher's exact test were used to observe an association between the qualitative data and outcome variables. Unpaired T-Test and Mann-Whitney U test were used for analysis of the quantitative data. A p<0.05 was considered statistically significant.
   Results: A total of 104 patients were included. The mean number of dressings per patient was significantly lower in the NPWT group (3.4) than in the control group (20.7) (p<0.001). The time between injury and complete closure (12.5 versus 21.4 days) as well as duration of hospital stay (17.3 versus 23.8 days) was significantly less in the NPWT group (p<0.05).
   Conclusion: NPWT has a role in healing traumatic wounds and can be delivered effectively through hospital suction NPWT, which can also reduce the cost of therapy. We recommend its regular use in all patients presenting with post-traumatic, soft-tissue injuries when primary coverage is not possible.
C1 [Kaushik, D.] Safdarjang Hosp, Sports Injury Ctr, New Delhi, India.
   [Joshi, N.; Kumar, R.; Kumar, K.] Sawai Man Singh Med Coll & Hosp, Jaipur, Rajasthan, India.
   [Gaba, S.] AIIMS, Dept Orthopaed, New Delhi, India.
   [Sapra, R.] Bhagwan Mahavir Hosp, Dept Orthopaed, New Delhi, India.
C3 Vardhman Mahavir Medical College & Safdarjung Hospital; SMS Medical
   College & Hospital; All India Institute of Medical Sciences (AIIMS) New
   Delhi
RP Kaushik, D (通讯作者)，Safdarjang Hosp, Sports Injury Ctr, New Delhi, India.
EM devwartkaushik@gmail.com
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NR 40
TC 8
Z9 13
U1 0
U2 18
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2017
VL 26
IS 10
BP 600
EP 606
DI 10.12968/jowc.2017.26.10.600
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FI9ZR
UT WOS:000412368800005
PM 28976825
DA 2026-07-24
ER
PT J
AU Raphael, A
   Gonzales, J
AF Raphael, A.
   Gonzales, J.
TI Use of cryopreserved umbilical cord with negative pressure wound therapy
   for complex diabetic ulcers with osteomyelitis
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE complex wounds; diabetic foot ulcer; NPWT; osteomyelitis; cryopreserved
   umbilical cord
ID AMNIOTIC MEMBRANE
AB Objective: The objective of this study was to evaluate the combined use of cryopreserved human umbilical cord (cUC) allograft and negative pressure wound therapy (NPWT) in treating complex diabetic foot ulcers (DFUs) with bone exposure and osteomyelitis. These types of wound are known to carry a high morbidity and mortality.
   Methods: A single-center, retrospective chart review was performed to assess the efficacy of the combined use of cUC with NPWT, by the same surgeon, to help promote the closure of complex DFUs presenting with biopsy-proven osteomyelitis. Change in wound size and volume, time to wound closure, and number of cUC applications were assessed.
   Results: We identified of 14 wounds in 13 patients, with an average initial wound area of (mean +/- standard devaition) 33.2 +/- 21.7cm(2) and wound volume of 52 +/- 26.2cm(3). All achieved complete re-epithelialisation with an average time to closure of 24.0 +/- 10.9 weeks, using between 2-5 cUC applications. No adverse events were noted and none of the wounds required limb amputation during the a follow-up of 24 months for each patient.
   Conclusion: The results suggest that combined use of cUC and NPWT may be effective in improving the healing of complex DFUs that present with osteomyelitis. Prospective, randomised controlled trials are warranted to confirm this efficacy as well as its potential applications in other chronic wounds.
C1 [Raphael, A.] Village Podiatry Ctr, Smyrna, GA 30082 USA.
   [Gonzales, J.] Dekalb Med Podiatr Residency, PGY3, Decatur, GA USA.
RP Raphael, A (通讯作者)，Village Podiatry Ctr, Smyrna, GA 30082 USA.
EM ARaphael@vpcenters.com
FU Amniox Medical; Acelity
FX Dr Raphael is a paid consultant for Amniox Medical and Acelity.
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NR 14
TC 16
Z9 21
U1 0
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2017
VL 26
IS 10
SU S
BP S38
EP S44
DI 10.12968/jowc.2017.26.Sup10.S38
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FI9ZU
UT WOS:000412369100006
PM 28976835
DA 2026-07-24
ER
PT J
AU Herskovitz, I
   MacQuhae, FE
   Borda, LJ
   Bhagwandin, S
   Paredes, JA
   Polanco, T
   Lantis, JC
   Kim, PJ
   Phillips, TJ
   Kirsner, RS
AF Herskovitz, Ingrid
   MacQuhae, Flor E.
   Borda, Luis J.
   Bhagwandin, Stephanie
   Paredes, Juan A.
   Polanco, Thais
   Lantis, John C., II
   Kim, Paul J.
   Phillips, Tania J.
   Kirsner, Robert S.
TI A Novel Topical Wound Therapy Delivery System
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE topical delivery system; wound dressing; negative pressure wound
   therapy; wound irrigation
ID INTRALESIONAL SODIUM THIOSULFATE; VACUUM-ASSISTED CLOSURE; THICKNESS
   WOUNDS; CLINICAL-TRIAL; BETA-BLOCKER; CALCIPHYLAXIS; INSTILLATION;
   INFLAMMATION; STANOZOLOL; DRESSINGS
AB Introduction. Wound care dressings have, evolved over time, from bandaging to the development of occlusive dressings to negative pressure wound therapy. A novel therapeutic delivery syStem dressing has been cleared by the United States Food and Drug Administration. This semi occlusive wound dressing has been, developed to provide local, continuous delivery of aqueous topical agents, such as therapeutics (anes-thetics, antiseptics, antibiotics, steroids, topical bet-blockers, immune modulatory agents, growth factors, and fibrinolytic agents, among others), at a rate of about 3/4 mL per day, thus maintaining a hydrated environment and providing topical treatment. This type of system may be beneficial in situations where systemic therapies cannot be used, wounds are small and few, wounds may need frequent application of medication or moisture, or low and steady delivery of medications is needed. Objective. The authors assessed a delivery system dressing with different types of liquid medications for the management of hard-to-heal, chronic lower extremity wounds. Materials and Methods. Patients aged >= 18 ands <= 90 years with stalled chronic wounds > 30 days' duration were selected for the use of a topical delivery system, which consists of a semi occlusive wound dressing and fluid delivery unit that can provide local application of small therapeutic quantities of medication directly to the wound. Results. Several successful cases with the use of this device are presented in which pain, relief., enhancement of epithelial migration, inflammation reduction, bacterial control, and wound size reduction were achiieved. Conclusions. This delivery system dressing is an effective and safe treatment option for wounds. Advantages include reduced potential of systemic side effects, flexibility in what can be delivered, constant rate of medication delivery, and convenience.
C1 [Herskovitz, Ingrid; MacQuhae, Flor E.; Borda, Luis J.; Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, 1600 NW 10th Ave,Rosenstiel Med Sci Bldg, Miami, FL 33136 USA.
   [Bhagwandin, Stephanie; Paredes, Juan A.; Polanco, Thais; Lantis, John C., II] Mt Sinai St Lukes Hosp, New York, NY USA.
   [Kim, Paul J.] MedStar Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
   [Phillips, Tania J.] Boston Univ, Sch Med, Boston Med Ctr, Dermatol Wound Clin, Boston, MA 02118 USA.
C3 University of Miami; Mount Sinai Morningside; Georgetown University;
   Boston Medical Center; Boston University
RP Kirsner, RS (通讯作者)，Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, 1600 NW 10th Ave,Rosenstiel Med Sci Bldg, Miami, FL 33136 USA.
EM Rkirsner@miami.edu
OI Phillips, Tania/0000-0003-2744-4931; , Paul/0000-0002-6186-6890
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NR 45
TC 4
Z9 4
U1 0
U2 10
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2017
VL 29
IS 9
BP 269
EP 276
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FJ0CR
UT WOS:000412376600005
PM 28933696
DA 2026-07-24
ER
PT J
AU Cherubino, M
   Valdatta, L
   Tos, P
   D'Arpa, S
   Troisi, L
   Igor, P
   Corradi, F
   Khan, U
AF Cherubino, Mario
   Valdatta, Luigi
   Tos, Pierluigi
   D'Arpa, Salvatore
   Troisi, Luigi
   Igor, Pellegatta
   Corradi, Federica
   Khan, Umraz
TI Role of Negative Pressure Therapy as Damage Control in Soft Tissue
   Reconstruction for Open Tibial Fractures
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE damage control; negative pressure wound therapy; limb trauma; soft
   tissue; microsurgical reconstruction
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY TRAUMA; WOUND THERAPY; VASCULAR
   INJURIES; MANAGEMENT; COVERAGE; FLAP; SALVAGE
AB The concept of damage control orthopaedics (DCO) is a strategy that focuses on managing orthopaedic injuries in polytrauma patients who are in an unstable physiological state. The concept of DCO is an extension of damage control surgery or damage limitation surgery (DCS/DLS). Recently, it has become clear that certain patients, following extensive soft tissue trauma, could benefit from the idea of DCS. In the management of severe lower extremity trauma with exposed fracture sites, aggressive early wound excision debridement, early internal fixation, and vascularized wound coverage within a few days after trauma were proposed. A negative-pressure dressing can be easily and rapidly applied to obtain a temporary closure between surgical stages. While negative pressure wound therapy (NPWT) has clear indications in the management of chronic wounds, its applications in the acute setting in victims of polytrauma are uneven. We conducted a review of the current clinical literature to evaluate the role of NPWT in this field, which points out that the negative pressure, applied immediately after the first debridement, seems to be an optimal bridge to the final reconstruction up to 7 days.
C1 [Cherubino, Mario; Valdatta, Luigi; Igor, Pellegatta; Corradi, Federica] Univ Insubria, Div Plast & Reconstruct Surg, Dept Biotechnol & Life Sci, Varese, Italy.
   [Tos, Pierluigi] ASST Gaetano Pini, Dept Orthopaed & Traumatol Hand, Milan, Italy.
   [D'Arpa, Salvatore] Ghent Univ Hosp, Dept Plast & Reconstruct Surg, Ghent, Belgium.
   [D'Arpa, Salvatore] Univ Palermo, Div Plast & Reconstruct Surg, Dept Surg Oncol & Oral Sci, Palermo, Italy.
   [Troisi, Luigi; Khan, Umraz] North Bristol NHS Trust, Southmead Hosp, Dept Plast & Reconstruct Surg, Bristol, Avon, England.
C3 University of Insubria; ASST Gaetano Pini CTO; Ghent University; Ghent
   University Hospital; University of Palermo; North Bristol NHS Trust;
   Southmead Hospital
RP Cherubino, M (通讯作者)，Univ Insubria, Div Plast & Reconstruct Surg, ASST Sette Laghi, Dept Biotechnol & Life Sci, Viale Borri 57, I-21100 Verese, VA, Italy.
EM mario.cherubino@gmail.com
RI tos, pierluigi/R-5803-2016; Cherubino, Mario/N-1780-2019; Troisi,
   Luigi/AAA-6179-2022
OI tos, pierluigi/0000-0002-1349-7082; Cherubino,
   Mario/0000-0003-1196-3075; Troisi, Luigi/0000-0002-4754-3075
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NR 33
TC 21
Z9 28
U1 0
U2 10
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD OCT
PY 2017
VL 33
SU 1
BP S8
EP S13
DI 10.1055/s-0037-1606542
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FJ1YG
UT WOS:000412516600003
PM 28985633
DA 2026-07-24
ER
PT J
AU Bao, TZ
   Han, F
   Xu, F
   Yang, Y
   Shu, X
   Chen, K
   Qi, BW
   Wei, SJ
   Yu, AX
AF Bao, Tongzhu
   Han, Fang
   Xu, Feng
   Yang, Yi
   Shu, Xun
   Chen, Ken
   Qi, Baiwen
   Wei, Shijun
   Yu, Aixi
TI Papineau technique combined with vacuum-assisted closure for open tibial
   fractures: clinical outcomes at five years
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
DE Bone graft; Open fracture; Papineau technique; Segmental bone defect;
   Tibia fracture; Vacuum-assisted closure
ID PRESSURE WOUND THERAPY; EVIDENCE-BASED RECOMMENDATIONS; LOWER-EXTREMITY;
   BONE TRANSPORT; POSTTRAUMATIC OSTEOMYELITIS; INTERNATIONAL CONSENSUS;
   LIMB SALVAGE; RECONSTRUCTION; MANAGEMENT; NONUNIONS
AB Purpose Treatment of open tibial fractures with soft tissue and segmental bone defects is difficult. This study reports our results for treating these injuries with a combination of Papineau open bone grafting and vacuum-assisted wound closure (VAC).
   Methods The records of 19 patients with open tibial fractures with soft tissue and segmental bone defects treated with bone grafting and VAC from 2004 to 2010 were retrospectively reviewed. Outcomes included: time to complete granulation tissue coverage, wound healing, and bone union; length of hospitalization; frequency of debridement; number of deep tissue infections.
   Results Initial surgery was performed within 48 hours of injury. Ten fractures were Orthopaedic Trauma Association classification 41-A3, one was 41-C3, seven were 43-A3, and one was 43-C3. No surgical complications occurred, and the mean length of hospitalization was 11.0 +/- 3.0 weeks (range, 7-18 weeks). The mean follow-up time was 59.35 +/- 8.76 months. The mean time for complete wound healing was 7.76 +/- 1.52 weeks (range, 6-11 weeks). Bone union was achieved in all patients at a mean of 33.88 +/- 8.37 weeks (range, 23-53 weeks). Only one patient developed a deep tissue infection, which was treated with antibiotics and debridements, and complete bone union wound healing was achieved. Based on Paley grade, five outcomes were excellent, eight were good, and four were fair.
   Conclusions The combination of VAC and open bone grafting results in good outcome for patients with open tibial fractures and severe bone and soft-tissue defects.
C1 [Bao, Tongzhu; Yang, Yi; Shu, Xun; Chen, Ken] China Three Gorges Univ, Dept Orthoped, Yichang Cent Peoples Hosp, Yichang 443002, Peoples R China.
   [Bao, Tongzhu; Yang, Yi; Shu, Xun; Chen, Ken] China Three Gorges Univ, Affiliated Hosp 1, Yichang 443002, Peoples R China.
   [Han, Fang; Xu, Feng; Wei, Shijun] Wuhan Gen Hosp, Dept Orthoped, Hongshan Area, 627 Wuluo Rd, Wuhan 430070, Hubei, Peoples R China.
   [Qi, Baiwen; Yu, Aixi] Wuhan Univ, Dept Microsurg, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
C3 China Three Gorges University; China Three Gorges University; Wuhan
   University
RP Wei, SJ (通讯作者)，Wuhan Gen Hosp, Dept Orthoped, Hongshan Area, 627 Wuluo Rd, Wuhan 430070, Hubei, Peoples R China.; Yu, AX (通讯作者)，Wuhan Univ, Dept Microsurg, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
EM wsj1974@yeah.net; yuaixi666@163.com
RI Yang, Yi/MIU-4567-2025
OI Shijun, Wei/0000-0001-5105-0196
FU National Natural Science Foundation of China [81572163]; Wuhan
   Cultivation Program for Middle-aged and Young Medical Talents [2014-77]
FX This study is supported by the National Natural Science Foundation of
   China (General Program) [Grant No. 81572163] and the Wuhan Cultivation
   Program for Middle-aged and Young Medical Talents [Grant No. 2014-77].
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NR 28
TC 17
Z9 20
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD NOV
PY 2017
VL 41
IS 11
BP 2389
EP 2396
DI 10.1007/s00264-017-3620-1
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA FJ5BA
UT WOS:000412757900024
PM 28849424
DA 2026-07-24
ER
PT J
AU Hattori, K
   Numanoglu, A
   Cox, S
AF Hattori, Kengo
   Numanoglu, Alp
   Cox, Sharon
TI Temporary Vacuum-Assisted Closure of the Open Abdomen in Neonates
SO EUROPEAN JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE vacuum-assisted closure; open abdomen; neonate; temporary abdominal
   closure; abdominal compartment syndrome
ID PRESSURE WOUND THERAPY; ABDOMINAL WOUNDS; CHILDREN; INFANTS; EXPERIENCE
AB Introduction The need for open abdomen in the treatment of severely ill neonates will increase in time as more complex abdominal procedures are undertaken. However, the experience of temporary closure of an open abdomen using vacuum-assisted closure (VAC) system is still relatively limited in premature and term neonates. The aim of this study is to describe and review our experience in the use of temporary VAC of the open abdomen for neonates with varying pathological processes. Materials and Methods A retrospective folder review of all neonates treated with VAC for open abdomen over the study period of 2010 to 2014 at our institution was performed. Results A total of 15 neonates were included in this study. Mean gestational age and postbirth age at VAC application were 33.64.1 (28-40) weeks and 14 +/- 10.2 (2-30) days, respectively. Mean weight at VAC application was 1,797.7 +/- 730.8 (960-3,200) g. Initial diagnoses were necrotizing enterocolitis (seven), intestinal perforation (three), gastroschisis (two), congenital diaphragmatic hernia (two), and primary abdominal compartment syndrome (ACS) (one). Reasons for VAC application included confirmed ACS (2) and application to prevent ACS (13). Duration of VAC use was 4 +/- 3.4 (0-13) days during which 2 +/- 1.2 (1-5) applications were performed. Overall survival rate was 80% (12 of 15 patients). One patient with primary ACS died from sepsis with an open abdomen. The only potential VAC-related complication was an enterocutaneous fistula. Conclusion Temporary VAC of the open abdomen is a safe method of temporary abdominal closure to prevent ACS in high-risk postoperative conditions in neonates of any gestational age and birth weight.
C1 [Hattori, Kengo; Numanoglu, Alp; Cox, Sharon] Univ Cape Town, Red Cross War Mem Childrens Hosp, Div Paediat Surg, Klipfontein Rd, ZA-7700 Cape Town, Western Cape, South Africa.
C3 University of Cape Town
RP Hattori, K (通讯作者)，Univ Cape Town, Red Cross War Mem Childrens Hosp, Div Paediat Surg, Klipfontein Rd, ZA-7700 Cape Town, Western Cape, South Africa.
EM ken5hattori@gmail.com
RI Hattori, Kengo/AAJ-2995-2021; Cox, Sharon Gail/H-3038-2016; Numanoglu,
   Alp/ITW-0564-2023
OI Hattori, Kengo/0000-0003-2650-3370; Cox, Sharon
   Gail/0000-0002-3175-8741; Numanoglu, Alp/0000-0003-2026-6423
CR [Anonymous], 2009, PRINCIPLES BEST PRAC
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NR 19
TC 8
Z9 9
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0939-7248
EI 1439-359X
J9 EUR J PEDIATR SURG
JI Eur. J. Pediatr. Surg.
PD OCT
PY 2017
VL 27
IS 5
BP 437
EP 442
DI 10.1055/s-0036-1598010
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA FJ7LD
UT WOS:000412938300011
PM 28099974
DA 2026-07-24
ER
PT J
AU Tsuji, T
   Satoh, K
   Okuno, E
   Sobue, A
   Nishide, Y
   Tanaka, S
   Kogo, M
AF Tsuji, Tadataka
   Satoh, Koichi
   Okuno, Emi
   Sobue, Akiko
   Nishide, Yoshiya
   Tanaka, Susumu
   Kogo, Mikihiko
TI The utility of vacuum-assisted closure therapy for skin necrosis
   secondary to cervical abscess in the elderly
SO AURIS NASUS LARYNX
LA English
DT Article
DE Vacuum-assisted closure; Neck abscess; Skin necrosis; Oldest-old
   patient; Low albumin
AB Vacuum-assisted closure (VAC) systems have been used as negative-pressure dressings in various fields, including decubitus ulcer, trauma, and wound dehiscence. To the best of our knowledge, few reports have examined the utility of VAC therapy for neck abscess in an oldest-old patient. We present here a rare case of neck abscess secondary to parotid abscess, resulting in extensive skin necrosis. Successful management included emergency drainage following epithelial induction through a VAC system without using skin grafting. Two months after surgical intervention, the cervical wound was completely healed without a solid scar. We consider the VAC therapy to be a key factor leading to the complete healing in the elderly under low serum albumin condition. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Tsuji, Tadataka; Satoh, Koichi; Okuno, Emi; Sobue, Akiko] Saiseikai Matsusaka Gen Hosp, Dept Oral & Maxillofacial Surg, 15-6 Asahimachi 1 Ku, Matsusaka, Mie 5158557, Japan.
   [Nishide, Yoshiya] Saiseikai Matsusaka Gen Hosp, Dept Radiol, 15-6 Asahimachi 1 Ku, Matsusaka, Mie 5158557, Japan.
   [Tsuji, Tadataka; Tanaka, Susumu; Kogo, Mikihiko] Osaka Univ, Dept Oral & Maxillofacial Surg 1, Grad Sch Dent, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan.
C3 University of Osaka
RP Tsuji, T (通讯作者)，Saiseikai Matsusaka Gen Hosp, Dept Oral & Maxillofacial Surg, 15-6 Asahimachi 1 Ku, Matsusaka, Mie 5158557, Japan.
EM g2787b@dent.osaka-u.ac.jp
RI ; Kogo, Mikihiko/ABD-7080-2020; /AAN-9471-2020
OI Tsuji, Tadataka/0000-0002-2837-8246; 
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   [Anonymous], 2013, COMP EFFECTIVENESS R
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Dowsett C., 2005, Wounds UK, V1, P58
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NR 8
TC 1
Z9 2
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0385-8146
EI 1879-1476
J9 AURIS NASUS LARYNX
JI Auris Nasus Larynx
PD DEC
PY 2017
VL 44
IS 6
BP 749
EP 753
DI 10.1016/j.anl.2016.11.008
PG 5
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA FJ9AV
UT WOS:000413060700018
PM 27932078
DA 2026-07-24
ER
PT J
AU Toogood, P
   Miclau, T
AF Toogood, Paul
   Miclau, Theodore
TI Critical-Sized Bone Defects: Sequence and Planning
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE bone defect; soft tissue management; trauma
ID PRESSURE WOUND THERAPY; SEVERE OPEN FRACTURES; DEEP-INFECTION-RATE;
   EXTRUDED TALUS; TIBIAL SHAFT; ANTIBIOTIC-PROPHYLAXIS; FLAP COVERAGE;
   MANAGEMENT; REIMPLANTATION; CLOSURE
AB Bone defects associated with open fractures require a careful approach and planning. At initial presentation, an emergent irrigation and debridement is required. Immediate definitive fixation is frequently safe, with the exception of those injuries that normally require staged management or very severe type IIIB and IIIC injuries. Traumatic wounds that can be approximated primarily should be closed at the time of initial presentation. Wounds that cannot be closed should have a negative pressure wound therapy dressing applied. The need for subsequent debridements remains a clinical judgment, but all nonviable tissue should be removed before definitive coverage. Cefazolin remains the standard of care for all open fractures, and type III injuries also require gram-negative coverage. Both induced membrane technique with staged bone grafting and distraction osteogenesis are excellent options for bony reconstruction. Soft tissue coverage within 1 week of injury seems critical.
C1 [Toogood, Paul; Miclau, Theodore] Univ Calif San Francisco, UCSF ZSFG Orthoped Trauma Inst, Dept Orthopaed Surg, 2550 23rd St,Bldg 9,2nd Floor, San Francisco, CA 94110 USA.
C3 University of California System; University of California San Francisco
RP Toogood, P (通讯作者)，Univ Calif San Francisco, UCSF ZSFG Orthoped Trauma Inst, Dept Orthopaed Surg, 2550 23rd St,Bldg 9,2nd Floor, San Francisco, CA 94110 USA.
EM Paul.toogood@ucsf.edu
FU NIAMS NIH HHS [R01 AR057344, R01 AR053645, R21 AR066847] Funding Source:
   Medline
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NR 49
TC 25
Z9 28
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD OCT
PY 2017
VL 31
SU 5
BP S23
EP S26
DI 10.1097/BOT.0000000000000980
PG 4
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA FK2DR
UT WOS:000413293300006
PM 28938387
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ma, ZJ
   Li, ZH
   Shou, KQ
   Jian, C
   Li, PC
   Niu, YH
   Qi, BW
   Yu, AX
AF Ma, Zhanjun
   Li, Zonghuan
   Shou, Kangquan
   Jian, Chao
   Li, Pengcheng
   Niu, Yahui
   Qi, Baiwen
   Yu, Aixi
TI Negative pressure wound therapy: Regulating blood flow perfusion and
   microvessel maturation through microvascular pericytes
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE blood flow perfusion; collagen type IV; negative pressure wound therapy;
   pericytes; vessel maturation
ID VACUUM-ASSISTED CLOSURE; TUMOR ANGIOGENESIS; VESSEL MATURATION;
   RECRUITMENT; ANGIOPOIETINS; HETEROGENEITY
AB Negative pressure wound therapy (NPWT) has been demonstrated to accelerate wound healing by promoting angiogenesis. However, whether blood flow perfusion is regulated by microvessel maturation and pericytes following NPWT remains unclear, as well as the exact association between pericytes and collagen type IV. The aim of this study was to investigate the relevant association between blood flow perfusion and microvessel maturation and pericytes following NPWT, and to further explore the underlying molecular mechanisms. We also aimed to investigate the association between pericytes and collagen type IV. For this purpose, we created a rat model of diabetic wounds and microvascular blood flow perfusion was detected using a laser Doppler blood perfusion imager. The expression levels of angiogenin-1, tyrosine phosphorylation of tyrosine kinase receptor-2 (Tie-2), alpha-smooth muscle actin (alpha-SMA) and collagen type IV were detected and analyzed through immunohistochemistry, immunofluorescence, RT-qPCR and western blot analysis. The results revealed that NPWT promoted the overexpression of angiogenin-1, Tie-2, alpha-SMA and collagen type IV, and significantly increased blood flow perfusion coupled with microvessel maturation in the NPWT group at the later stages (7-10 days) of wound healing. Our results suggested that NPWT can preferentially enhance vessel maturation and increase the number of pericytes, thus regulating blood flow perfusion. On the other hand, pericytes and collagen type IV had a mutual interaction, promoting microvessel maturation.
C1 [Ma, Zhanjun; Li, Zonghuan; Shou, Kangquan; Jian, Chao; Li, Pengcheng; Niu, Yahui; Qi, Baiwen; Yu, Aixi] Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Qi, BW; Yu, AX (通讯作者)，Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM wb002162@whu.edu.cn; yuaixi@whu.edu.cn
RI Li, Pengcheng/ABF-5376-2021; /E-6566-2018
FU National Natural Science Foundation of China [81572163]; Hubei National
   Natural Science Fund [2014CFB751]
FX This study was supported by the National Natural Science Foundation of
   China (no. 81572163) and by the Hubei National Natural Science Fund
   projects (no. 2014CFB751). We would like to acknowledge the Wuhan VSD
   Medical Science and Technology, Co., Ltd. (Wuhan, China) for supplying
   the vacuum material. We would also like to thank the Medical Science
   Experimentation Center of Wuhan University providing the experiment
   equipment. This study has been satisfactorily edited for proper English
   by an agent of the English Editing Service of Experimental Biology and
   Medicine.
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NR 45
TC 54
Z9 73
U1 0
U2 16
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD NOV
PY 2017
VL 40
IS 5
BP 1415
EP 1425
DI 10.3892/ijmm.2017.3131
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FK3PS
UT WOS:000413398800012
PM 28901392
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Patera, M
   Mizera, R
AF Patera, M.
   Mizera, R.
TI Severe Lower Extremity Infections Treated with Hip Disarticulation -
   Case Series
SO ACTA CHIRURGIAE ORTHOPAEDICAE ET TRAUMATOLOGIAE CECHOSLOVACA
LA Czech
DT Article
DE hip disarticulation; infection; necrotizing fasciitis
ID VACUUM-ASSISTED CLOSURE; NECROTIZING FASCIITIS; WOUND CONTROL;
   EXPERIENCE; MORTALITY; AMPUTEES
AB Hip disarticulation is a major ablative procedure with serious risks as well as consequences for the patient, performed rarely for a lower extremity infection. According to literature, the mortality rate in these procedures reaches up to 60%. Unfavourable prognostic factors are emergency surgeries without adequate preparation of the patient and surgeries indicated for an ischemic terrain infection.
   The authors present four cases of hip disarticulation for severe lower extremity infection. In one patient, the procedure was performed urgently for necrotising fasciitis in the lower extremity extending up to the groin area, in the other three patients for non-healing femoral stump infection following the lower extremity amputation for vascular causes, of which two cases got complicated by the presence of TKA. Two of the patients treated surgically for stump infection died two months after the surgery due to respiratory complications. The two surviving patients underwent the last check one year following the surgery, they are both capable of independent locomotion with two underarm crutches and use the prosthesis only rarely. In the discussion, the factors influencing the mortality rate of the procedure, the principles of surgical and antimicrobial therapy, and the use of the negative-pressure wound therapy are analysed. The underlying principles of the care for patients with severe infections of the musculoskeletal system are infection focus debridement with the removal of foreign material, antibiotic (anti-infective) therapy targeted based on the cultivation results, wound management aimed to prevent contamination with nosocomial strains, and multidisciplinary cooperation orthopaedist/surgeon, infectious disease physician, intensive care specialist, nutrition and rehabilitation specialist, nursing and prosthetic care providers.
C1 [Patera, M.; Mizera, R.] Krajska Nemocnice Liberec As, Traumatol Ortopedicke Ctr, Oddeleni Ortopedie, Husova 357-10, Liberec 46063, Czech Republic.
RP Patera, M (通讯作者)，Krajska Nemocnice Liberec As, Traumatol Ortopedicke Ctr, Oddeleni Ortopedie, Husova 357-10, Liberec 46063, Czech Republic.
EM martin.patera@nemlib.cz
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NR 18
TC 2
Z9 3
U1 0
U2 6
PU GALEN SRO
PI PRAGUE 5
PA NA BELIDLE 34, PRAGUE 5, 150 00, CZECH REPUBLIC
SN 0001-5415
J9 ACTA CHIR ORTHOP TR
JI Acta Chir. Orthop. Traumatol. Cechoslov.
PD OCT
PY 2017
VL 84
IS 5
BP 396
EP 400
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA FL3IS
UT WOS:000414117200012
PM 29351543
DA 2026-07-24
ER
PT J
AU Luo, J
   Yao, HL
   Lei, SL
   Xie, Y
AF Luo, Jing
   Yao, Hongliang
   Lei, Sanlin
   Xie, Yong
TI Recurrent pelvic stromal tumor with colon fistula of left leg: a case
   report
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Gastrointestinal stromal tumors; colon fistula of left leg; sunitinib;
   case report; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; IMATINIB MESYLATE; ADJUVANT IMATINIB; WOUNDS;
   TRIAL; DIAGNOSIS; PRESSURE
AB The oral tyrosine kinase inhibitor (TKI), sunitinib malate, has been widely used in patients with gastroin-testinal stromal tumors (GISTs). The formation of colon fistula of left leg during treatment with sunitinib for recurrent pelvic stromal tumor has not been described before. We describe a 47 years old man who had received several surgical resections and taken imatinib mesylate due to recurrent gastrointestinal stromal tumors. Recently, in consideration of imatinib resistance, the patient changed the drug from imatinib to sunitinib. Unfortunately, a fistula developed between the sigmoid colon cavity and the left leg skin. Thus, the patient received surgery under general anesthesia after active nutrition support therapy and the vacuum assisted closuretherapy was taken to promote wound healing and avoid skin grafting or reduce the grafting area. Finally, the patient was discharged with a better health condition without skin grafting. This is the first description of recurrent pelvic stromal tumor with colon fistula of left leg under sunitinib treatment. From this case, clinicians should raise awareness of the possibility of intestinal perforation and enterocutaneous fistula for patients with gastrointestinal stromal tumors, especially when the intestine is involved by tumor and under the treatment of molecular targeted drugs.
C1 [Luo, Jing; Yao, Hongliang; Lei, Sanlin; Xie, Yong] Cent S Univ, Xiangya Hosp 2, Dept Gastrointestinal Surg, Renmin Rd, Changsha 410011, Hunan, Peoples R China.
C3 Central South University
RP Yao, HL (通讯作者)，Cent S Univ, Xiangya Hosp 2, Dept Gastrointestinal Surg, Renmin Rd, Changsha 410011, Hunan, Peoples R China.
EM yaohl0326@csu.edu.cn
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NR 26
TC 0
Z9 1
U1 0
U2 11
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 10
BP 14813
EP 14820
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FL5QD
UT WOS:000414299700080
DA 2026-07-24
ER
PT J
AU De Coster, A
AF De Coster, A.
TI Linking challenges in wound healing: key highlights from the Hartmann
   congress
SO JOURNAL OF WOUND CARE
LA English
DT Article
ID MANAGEMENT
AB With a special focus on advanced wound healing (wound bed preparation, epithelialisation and hydration) and negative pressure wound therapy, the Hartmann LINK for Wound Healing Congress took place in Belfast, Northern Ireland, on 19 September. The event aimed to promote the latest advances in wound care and highlight the main challenges that clinicians face when treating different types of wounds.
CR Clokie M, 2017, DIABETIC MED, V34, P305, DOI 10.1111/dme.13313
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   Geiger SE, 2016, WOUNDS, V28, P306
NR 3
TC 1
Z9 1
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2017
VL 26
IS 11
BP 696
EP 698
PG 2
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FL5VA
UT WOS:000414312600011
PM 29131747
DA 2026-07-24
ER
PT J
AU Hofmann, AT
   Gruber-Blum, S
   Lechner, M
   Petter-Puchner, A
   Glaser, K
   Fortelny, R
AF Hofmann, Anna Theresa
   Gruber-Blum, Simone
   Lechner, Michael
   Petter-Puchner, Alexander
   Glaser, Karl
   Fortelny, Ren
TI Delayed closure of open abdomen in septic patients treated with negative
   pressure wound therapy and dynamic fascial suture: the long-term
   follow-up study
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Secondary peritonitis; Open abdomen; Negative pressure wound therapy;
   Dynamic fascial suture; Delayed closure
ID VENTRAL HERNIA; MESH; TRACTION; INCISIONS
AB Negative pressure wound therapy (NPWT) is widely used in the treatment of open abdomen (OA). The use of dynamic fascial sutures (DFS) increases the rate of successful delayed closure by reducing fascial lateralization. We recently published a prospective controlled trial including 87 patients undergoing abdominal surgery for secondary peritonitis between 2007 and 2012. Patients were treated with NPWT and DFS for approximation of fascial edges. The present study represents a follow-up assessment of these patients 5-9 years after OA treatment with NPWT and DFS.
   The 39 patients still alive were included in the recent study according to the protocol of our last study in 2013. All patients received a questionnaire regarding long-term complications after OA treatment between 2007 and 2012. Mean follow-up was 5-9 years. Analyzed parameters included pain, the presence of incisional hernia, and subsequent surgical interventions. Results were analyzed quantitatively.
   One patient had deceased since the last publication in 2013, and hence 38 patients were included in the current study. The median age was 60.9 (25.2-86.1) years, and 17 (44.7%) were females. Overall 56.3% of the original 87 patients had died during the long-term follow-up period. 21 patients (55.3%) answered the questionnaire. Six (28.6%) declared that they suffered from pain in the previous operating field, five (23.8%) at rest, and three (14.3%) during exercise. In five patients (23.8%), pain lasted for more than 3 months. One patient (4.8%) still requires analgesic treatment. Among the 21 patients, seven (33.3%) were found to have incisional hernias. Three hernias (42.9%) were treated by surgery.
   Incisional hernia rates after OA treatment remain high, but are accompanied by little pain. The ideal technique of fascial closure after NPWT should be investigated in further research.
C1 [Hofmann, Anna Theresa; Gruber-Blum, Simone; Petter-Puchner, Alexander; Glaser, Karl; Fortelny, Ren] Wilhelminenspital Stadt Wien, Dept Gen Visceral & Oncol Surg, Montleartstr 37, A-1160 Vienna, Austria.
   [Lechner, Michael] Paracelsus Med Univ, Dept Surg, Mullner Hauptstr 48, A-5020 Salzburg, Austria.
   [Fortelny, Ren] Sigmund Freud Univ, Freudpl 1, A-1020 Vienna, Austria.
C3 Wilhelminenspital; Paracelsus Private Medical University
RP Hofmann, AT (通讯作者)，Wilhelminenspital Stadt Wien, Dept Gen Visceral & Oncol Surg, Montleartstr 37, A-1160 Vienna, Austria.
EM anna.hofmann@wienkav.at
RI /S-5290-2019; Fortelny, René/AAD-5922-2021
CR Bjarnason T, 2013, WORLD J SURG, V37, P2031, DOI 10.1007/s00268-013-2082-x
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NR 19
TC 15
Z9 16
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD NOV
PY 2017
VL 31
IS 11
BP 4717
EP 4724
DI 10.1007/s00464-017-5547-4
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FL6NI
UT WOS:000414361700047
PM 28424908
DA 2026-07-24
ER
PT J
AU Zeybek, B
   Li, S
   Fernandez, JW
   Stapley, S
   Silberschmidt, VV
   Liu, Y
AF Zeybek, B.
   Li, S.
   Fernandez, J. W.
   Stapley, S.
   Silberschmidt, V. V.
   Liu, Y.
TI Computational modelling of wounded tissue subject to negative pressure
   wound therapy following trans-femoral amputation
SO BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
LA English
DT Article
DE Finite-element analysis; Biomechanics; Negative pressure wound therapy;
   Tissue oxygenation
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; EVIDENCE-BASED
   RECOMMENDATIONS; OXYGEN-TRANSPORT; INTERNATIONAL CONSENSUS;
   POLYURETHANE-FOAM; SKELETAL-MUSCLE; LASER-DOPPLER; MICROCIRCULATION;
   MANAGEMENT
AB Proof-of-concept computational models were developed and applied as tools to gain insights into biomechanical interactions and variations of oxygen gradients of wounded tissue subject to negative pressure wound therapy (NPWT), following trans-femoral amputation. A macro-scale finite-element model of a lower limb was first developed based on computed tomography data, and distributions of maximum and minimum principal stress values we calculated for a region of interest (ROI). Then, the obtained results were applied iteratively as new sets of boundary conditions for a specific spatial position in a capillary sub-model. Data from coupled capillary stress and mass- diffusion sub-models were transferred to the macro-scale model to map the spatial changes of tissue oxygen gradients in the ROI. The -70 mmHg NPWT resulted in a dramatic change of a wound surface area and the greatest relative contraction was observed at -150 mmHg. Tissue lateral to the depth of the wound cavity revealed homogenous patterns of decrease in oxygenation area and the extent of such decrease was dependent on the distance from the wound surface. However, tissue lateral to the width of the wound demonstrated heterogeneous patterns of change, as evidenced by both gradual increase and decrease in the oxygenation area. The multiscale models developed in the current study showed a significant influence of NPWT on both macro-deformations and changes of tissue oxygenation. The patterns of changes depended on the depth of the tissue, the geometry of the wound, and also the location of tissue plane.
C1 [Zeybek, B.; Li, S.; Silberschmidt, V. V.; Liu, Y.] Loughborough Univ Technol, Wolfson Sch Mech Elect & Mfg Engn, Loughborough, Leics, England.
   [Fernandez, J. W.] Auckland Univ, Auckland Bioengn Inst, Auckland, New Zealand.
   [Fernandez, J. W.] Auckland Univ, Dept Engn Sci, Auckland, New Zealand.
   [Stapley, S.] Royal Ctr Def Med, ICT Ctr, Birmingham, W Midlands, England.
   [Stapley, S.] Queen Alexandra Hosp, Dept Trauma & Orthoped, Portsmuth, England.
   [Liu, Y.] Loughborough Univ Technol, Ctr Biol Engn, Loughborough, Leics, England.
C3 Loughborough University; University of Auckland; University of Auckland;
   Royal Centre for Defence Medicine; Portsmouth Hospitals NHS Trust; Queen
   Alexandra Hospital; Loughborough University
RP Liu, Y (通讯作者)，Loughborough Univ Technol, Wolfson Sch Mech Elect & Mfg Engn, Loughborough, Leics, England.; Liu, Y (通讯作者)，Loughborough Univ Technol, Ctr Biol Engn, Loughborough, Leics, England.
EM Y.liu3@lboro.ac.uk
RI ; Li, Simin/A-8040-2015; Liu, Yang/A-4046-2011; Silberschmidt, Vadim
   V/G-7113-2011
OI Zeybek Saglam, Begum/0000-0001-6789-043X; Silberschmidt, Vadim
   V/0000-0003-3338-3311
FU Marie Sklodowska-Curie Research and Innovation Staff Exchange programme
   [FP7-PEOPLE-2012-IRSES, 318553]; Loughborough University, Wolfson School
   of Mechanical, Electrical and Manufacturing Engineering
FX BZ's exchange activity with Auckland University was supported by the
   Marie Sklodowska-Curie Research and Innovation Staff Exchange programme
   (FP7-PEOPLE-2012-IRSES, 318553), and BZ's PhD study was partially funded
   by Loughborough University, Wolfson School of Mechanical, Electrical and
   Manufacturing Engineering.
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NR 54
TC 5
Z9 8
U1 0
U2 19
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1617-7959
EI 1617-7940
J9 BIOMECH MODEL MECHAN
JI Biomech. Model. Mechanobiol.
PD DEC
PY 2017
VL 16
IS 6
BP 1819
EP 1832
DI 10.1007/s10237-017-0921-7
PG 14
WC Biophysics; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Engineering
GA FL7SK
UT WOS:000414450200001
PM 28553679
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Kaul, P
AF Kaul, Pankaj
TI Sternal reconstruction after post-sternotomy mediastinitis
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Review
DE Deep sternal wound infections; Mediastinitis; Sternal dehiscence;
   Negative pressure wound therapy; Pectoralis major flaps; Rectus
   abdominis flaps; Omental grafts; Latissimus dorsi flaps; Free flaps;
   Allogeneic bone grafts
ID MYOCUTANEOUS ADVANCEMENT FLAPS; OPEN-HEART-SURGERY; VASCULARIZED MUSCLE
   FLAPS; PRESSURE WOUND THERAPY; HIGH-RISK PATIENTS; MEDIAN STERNOTOMY;
   CARDIAC-SURGERY; OMENTAL-FLAP; ANTIBIOTIC-PROPHYLAXIS; CHEST-WALL
AB Background: Deep sternal wound complications are uncommon after cardiac surgery. They comprise sternal dehiscence, deep sternal wound infections and mediastinitis, which will be treated as varying expressions of a singular pathology for reasons explained in the text.
   Methodology and review: This article reviews the definition, prevalence, risk factors, prevention, diagnosis, microbiology and management of deep sternal wound infections and mediastinitis after cardiac surgery. The role of negative pressure wound therapy and initial and delayed surgical management is discussed with special emphasis on plastic techniques with muscle and omental flaps. Recent advances in reconstructive surgery are presented.
   Conclusions: Deep sternal wound complications no longer spell debilitating morbidity and high mortality. Better understanding of risk factors that predispose to deep sternal wound complications and general improvement in theatre protocols for asepsis have dramatically reduced the incidence of deep sternal wound complications. Negative pressure wound therapy and appropriately timed and staged muscle or omental flap reconstruction have transformed the outcomes once these complications occur.
C1 [Kaul, Pankaj] Leeds Gen Infirm, Leeds LS1 3EX, W Yorkshire, England.
   [Kaul, Pankaj] Leeds Gen Infirm, Great George St, Leeds LS1 3EX, W Yorkshire, England.
C3 University of Leeds; Leeds General Infirmary; University of Leeds; Leeds
   General Infirmary
RP Kaul, P (通讯作者)，Leeds Gen Infirm, Great George St, Leeds LS1 3EX, W Yorkshire, England.
EM pankajkaul784@btinternet.com
OI Kaul, Pankaj/0000-0002-5281-2014
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NR 76
TC 71
Z9 98
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD NOV 2
PY 2017
VL 12
AR 94
DI 10.1186/s13019-017-0656-7
PG 10
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA FL8WD
UT WOS:000414530700001
PM 29096673
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Thompson, E
AF Thompson, Elizabeth
TI Debridement Techniques and Non-Negative Pressure Wound Therapy Wound
   Management
SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
LA English
DT Article
DE Wound healing; Debridement techniques; Chronic wounds; Granulation;
   Epithelialization
ID OCCLUSIVE DRESSINGS; LEECH THERAPY; ANTIBACTERIAL PROPERTIES;
   HYDROGEN-PEROXIDE; MAGGOT-THERAPY; COPPER COMPLEX; GROWTH-FACTORS;
   DOUBLE-BLIND; ALOE-VERA; IN-VITRO
AB The importance of initial wound classification and daily reevaluation of wound stage cannot be understated. Products available to enhance healing are categorized based on the stage of wound healing to which they exert their effects. After patient stability has been verified, thorough debridement is critical to create an environment conducive for healing. The wound environment of acute and chronic wounds differs greatly, often requiring different management approaches.
C1 [Thompson, Elizabeth] North Carolina State Univ, Coll Vet Med, Surg, 1060 William Moore Dr, Raleigh, NC 27606 USA.
C3 North Carolina State University
RP Thompson, E (通讯作者)，North Carolina State Univ, Coll Vet Med, Surg, 1060 William Moore Dr, Raleigh, NC 27606 USA.
EM emthomp6@ncsu.edu
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NR 116
TC 3
Z9 7
U1 0
U2 28
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0195-5616
EI 1878-1306
J9 VET CLIN N AM-SMALL
JI Vet. Clin. N. Am.-Small Anim. Pract.
PD NOV
PY 2017
VL 47
IS 6
BP 1181
EP +
DI 10.1016/j.cvsm.2017.06.005
PG 23
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FM1GJ
UT WOS:000414721900006
PM 28781059
DA 2026-07-24
ER
PT J
AU Stanley, BJ
AF Stanley, Bryden J.
TI Negative Pressure Wound Therapy
SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
LA English
DT Article
DE Negative pressure wound therapy; Dressings; Healing; Skin; Wound
ID VACUUM-ASSISTED-CLOSURE; THICKNESS SKIN-GRAFTS; SEPTIC PERITONITIS;
   BACTERIAL LOAD; GROWTH-FACTORS; MANAGEMENT; PROLIFERATION;
   OSTEOMYELITIS; DRESSINGS; BOLSTER
AB Open wounds are regularly addressed in veterinary medicine and can be challenging to manage, especially when there is significant loss of full thickness skin. Traditional wound dressings are being replaced by modern synthetic materials, biologic wound dressings, and mechanical technologies to augment healing. Negative pressure wound therapy (NPWT) is one of the most successful mechanical adjuncts to wound healing. Experience with NPWT in veterinary medicine is not as extensive as in human medicine, but reports have been positive. This modality may become an invaluable adjunct to wound management and other surgical applications in both large and small animals.
C1 [Stanley, Bryden J.] Michigan State Univ, Coll Vet Med, 736 Wilson Rd, E Lansing, MI 48824 USA.
C3 Michigan State University
RP Stanley, BJ (通讯作者)，Michigan State Univ, Coll Vet Med, 736 Wilson Rd, E Lansing, MI 48824 USA.
EM stanle32@cvm.msu.edu
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NR 90
TC 25
Z9 34
U1 1
U2 22
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0195-5616
EI 1878-1306
J9 VET CLIN N AM-SMALL
JI Vet. Clin. N. Am.-Small Anim. Pract.
PD NOV
PY 2017
VL 47
IS 6
BP 1203
EP +
DI 10.1016/j.cvsm.2017.06.006
PG 19
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FM1GJ
UT WOS:000414721900007
PM 28797553
DA 2026-07-24
ER
PT J
AU Lee, YN
   Lee, JS
   Han, SK
   Jung, HK
AF Lee, Ye-Na
   Lee, Jong Seok
   Han, Seung-Kyu
   Jung, Hye-Kyung
TI Tissue Oxygenation and Negative-Pressure Wound Therapy When Applied to
   the Feet of Persons With Diabetes Mellitus: An Observational Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Diabetic foot; Negative-pressure wound therapy; Tissue oxygenation;
   Transcutaneous oxygen pressure
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; FOOT ULCERS;
   PREDICTIVE-VALUE; DELAY PROCEDURES; AMPUTATION; MACROCIRCULATION;
   VALUES; FLAP; SKIN
AB PURPOSE: Our group has reported that negative-pressure wound therapy (NPWT) decreases tissue oxygenation by 84% in the foot of diabetic patients because the pad of the connecting drainage tube and foam sponge of the NPWT system compress the wound bed. The purpose of this study was to determine whether an NPWT modified dressing application reduces tissue oxygenation in the feet of persons with diabetes mellitus.
   DESIGN: A prospective, clinical, observational study.
   SUBJECTS AND SETTING: We enrolled 30 patients with diabetic mellitus; their mean age was 63.9 11.2 years (mean standard deviation). All were cared for at the diabetic wound center at an academic tertiary medical center in South Korea between 2014 and January 2015.
   METHODS: Transcutaneous partial oxygen pressures (TcpO(2)) were measured to determine tissue oxygenation levels beneath modified NPWT dressings. A TcpO(2) sensor was fixed at the tarsometatarsal area of the contralateral unwounded foot. A negative pressure of -125 mm Hg was applied until TcpO(2) reached a plateau state; values were measured before, during, and after the modified NPWT. The Wilcoxon' and Mann-Whitney U tests were used to compare differences between these measurements.
   RESULTS: TcpO(2) levels decreased by 26% during the modified NPWT. Mean TcpO(2) values before, during, and after turning off the therapy were 54.3 +/- 15.3 mm Hg, 41.6 +/- 16.3 mm Hg, and 53.3 +/- 15.6 mm Hg (P < .05), respectively.
   CONCLUSION: Applying NPWT without the pad of the connecting drainage tube significantly reduces the amount of tissue oxygenation loss beneath foam dressings on the skin of the foot dorsum in diabetic patients.
C1 [Lee, Ye-Na; Lee, Jong Seok; Han, Seung-Kyu; Jung, Hye-Kyung] Korea Univ, Guro Hosp, Diabet Wound Ctr, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Han, SK (通讯作者)，Korea Univ, Guro Hosp, Dept Plast Surg, 148 Guro Dong, Seoul 152703, South Korea.
EM pshan@kumc.or.kr
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NR 27
TC 2
Z9 3
U1 1
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD NOV-DEC
PY 2017
VL 44
IS 6
BP 517
EP 523
DI 10.1097/WON.0000000000000378
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FM5MB
UT WOS:000415078100005
PM 29117076
DA 2026-07-24
ER
PT J
AU Hobeika, C
   Allard, MA
   Bucur, PO
   Naili, S
   Cunha, AS
   Cherqui, D
   Castaing, D
   Adam, R
   Vibert, E
AF Hobeika, Christian
   Allard, Marc-Antoine
   Bucur, Petru-Octav
   Naili, Salima
   Cunha, Antonio Sa
   Cherqui, Daniel
   Castaing, Denis
   Adam, Rene
   Vibert, Eric
TI Management of the Open Abdomen after Liver Transplantation
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID ABDOMINAL-WALL RECONSTRUCTION; VACUUM-ASSISTED CLOSURE; PRESSURE WOUND
   THERAPY; FASCIAL CLOSURE; VENTRAL HERNIA; TRAUMA
AB The optimal management of the open abdomen (OA) after liver transplantation (LT) is unclear. The negative pressure wound therapy (NPWT) has been shown to be safe and can increase the chance for early fascial closure in trauma or septic patients. However, little data are available on the specific setting of LT. We aimed to report our experience of OA after LT, marked by the recent use of NPWT.
   All patients with postponed wall closure after LT, from 2002 to 2014, in a single institution were included and retrospectively analyzed. Our management of OA after LT has shifted from skin-only closure (SOC) followed by abdominal wall reconstruction at a distance to the use of NPWT with early fascial closure.
   Of the 1559 LTs performed during the study period, immediate abdominal wall closure at the end of transplantation could not be achieved in 46 (2.9%) patients. Of them, SOC was performed in 22 (47.8%) patients, whereas vacuum-assisted closure (VAC) therapy was used in 24 (52.1%) patients. The comprehensive complication indexes (CCI) were similar [CCI: 66 (0-100) in the SOC group vs. 56 (0-100) in the VAC group; p = 0.55]. No evisceration or fistula occurred in both groups. One (4.2%) postoperative bleeding case was reported in the VAC group. Early fascial closure was achieved within a median of 5.5 days (1-12) for the 24 patients (100%) of the VAC group. In four of them, a biological mesh was necessary. Only nine patients (52.9%) of the survivors in the SOC group underwent abdominal reconstruction.
   The NPWT in patients with OA after LT enables early fascial closure with limited morbidity provided a specific attention is given to the risk of bleeding. These results support the use of NPWT as the first option in OA patients after LT.
C1 [Hobeika, Christian; Allard, Marc-Antoine; Bucur, Petru-Octav; Naili, Salima; Cunha, Antonio Sa; Cherqui, Daniel; Castaing, Denis; Adam, Rene; Vibert, Eric] Hop Paul Brousse, Ctr Hepatobiliaire, 14 Av Paul Vaillant Couturier, F-94800 Villejuif, France.
   [Allard, Marc-Antoine; Bucur, Petru-Octav; Cunha, Antonio Sa; Cherqui, Daniel; Castaing, Denis; Adam, Rene; Vibert, Eric] Univ Paris Sud, Villejuif, France.
   [Allard, Marc-Antoine; Cunha, Antonio Sa; Adam, Rene] INSERM, Unite 935, Inst Natl Sante & Rech, Paris, France.
   [Bucur, Petru-Octav; Cherqui, Daniel; Castaing, Denis; Vibert, Eric] INSERM, Unite 785, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Paul-Brousse - APHP; Universite Paris Saclay; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Institut National de la
   Sante et de la Recherche Medicale (Inserm)
RP Allard, MA (通讯作者)，Hop Paul Brousse, Ctr Hepatobiliaire, 14 Av Paul Vaillant Couturier, F-94800 Villejuif, France.; Allard, MA (通讯作者)，Univ Paris Sud, Villejuif, France.; Allard, MA (通讯作者)，INSERM, Unite 935, Inst Natl Sante & Rech, Paris, France.
EM marcantoineallard@yahoo.fr
RI Hobeika, Christian/AAN-5865-2020; Cherqui, Daniel/T-6831-2018; VIBERT,
   Eric/T-7746-2018; Allaes, Marc Antoine/HTM-5009-2023; sa cunha,
   antonio/B-5781-2012
OI Hobeika, Christian/0000-0002-9592-2520; sa cunha,
   antonio/0000-0003-4015-5368
CR Assirati G, 2016, TRANSPL P, V48, P383, DOI 10.1016/j.transproceed.2015.12.037
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NR 22
TC 6
Z9 8
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD DEC
PY 2017
VL 41
IS 12
BP 3199
EP 3204
DI 10.1007/s00268-017-4125-1
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FM5RK
UT WOS:000415095500027
PM 28717912
DA 2026-07-24
ER
PT J
AU Laimer, J
   Steinmassl, O
   Hechenberger, M
   Rasse, M
   Pikula, R
   Bruckmoser, E
AF Laimer, Johannes
   Steinmassl, Otto
   Hechenberger, Martin
   Rasse, Michael
   Pikula, Rajmond
   Bruckmoser, Emanuel
TI Intraoral Vacuum-Assisted Closure Therapy-A Pilot Study in
   Medication-Related Osteonecrosis of the Jaw
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID PRESSURE WOUND THERAPY; BISPHOSPHONATE-RELATED OSTEONECROSIS; TOOTH
   EXTRACTION; MANAGEMENT; ASSOCIATION; FOUNDATION; EXPERIENCE; SURGERY;
   SKIN
AB Purpose: For approximately 2 decades, vacuum-assisted closure (VAC) therapy has been widely used for the management of complex wounds and soft tissue defects on the external surface of the body. As yet, this technique has not been studied for intraoral wound management. Therefore, this study evaluated the feasibility, safety, and effectiveness of intraoral VAC therapy in patients with medication-related osteonecrosis of the jaw (MRONJ).
   Patients and Methods: After successful construction of an intraoral device providing sufficient airtight sealing, individually manufactured appliances were used in a prospective clinical trial of 3 patients using the VAC therapy system.
   Results: Intraoral VAC therapy showed some success and did not produce serious side effects. Different positive effects, such as formation of new granulation tissue, cessation of pain, and pus suppuration, were found.
   Conclusion: This prospective proof-of-principle study showed that intraoral VAC therapy is feasible and safe. It could play a role in the management of MRONJ and other types of intraoral wounds (eg, osteoradionecrosis, postoperative wound dehiscence, etc). (C) 2017 American Association of Oral and Maxillofacial Surgeons
C1 [Laimer, Johannes; Steinmassl, Otto; Hechenberger, Martin; Rasse, Michael; Bruckmoser, Emanuel] Univ Hosp Craniomaxillofacial & Oral Surg, Anichstr 35, A-6020 Innsbruck, Austria.
   [Pikula, Rajmond] Univ Hosp Plast Reconstruct & Aesthet Surg, Innsbruck, Austria.
RP Bruckmoser, E (通讯作者)，Univ Hosp Craniomaxillofacial & Oral Surg, Anichstr 35, A-6020 Innsbruck, Austria.
EM office@bruckmoser.info
FU Medical University Innsbruck, Innsbruck, Austria [EP16200331]
FX Dr Laimer and Dr Bruckmoser are named as inventors of the intraoral
   suctioning device and a request for a grant of a European patent for the
   method of manufacturing this appliance has been submitted by the Medical
   University Innsbruck, Innsbruck, Austria (reference number EP16200331).
   All other authors do not have any relevant financial relationships(s)
   with a commercial interest.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 29
TC 9
Z9 13
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
EI 1531-5053
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD OCT
PY 2017
VL 75
IS 10
BP 2154
EP 2161
DI 10.1016/j.joms.2017.02.033
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA FM6NZ
UT WOS:000415172000027
PM 28396234
DA 2026-07-24
ER
PT J
AU Redfern, RE
   Cameron-Ruetz, C
   O'Drobinak, SK
   Chen, JT
   Beer, KJ
AF Redfern, Roberta E.
   Cameron-Ruetz, Claire
   O'Drobinak, Simone K.
   Chen, John T.
   Beer, Karl J.
TI Closed Incision Negative Pressure Therapy Effects on Postoperative
   Infection and Surgical Site Complication After Total Hip and Knee
   Arthroplasty
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE primary hip arthroplasty; primary knee arthroplasty; surgical site
   infection; hematoma; seroma; negative pressure wound therapy
ID PROSPECTIVE RANDOMIZED-TRIAL; CLOSURE WOUND THERAPY; MANAGEMENT-SYSTEM;
   1ST EXPERIENCE; REVISION HIP; SURGERY; PREVENTION; FRACTURES; DRESSINGS;
   BURDEN
AB Background: The aim of this study is to determine whether negative pressure wound therapy, used prophylactically in clean surgical incisions, reduces surgical site infection, hematoma, and seroma after total joint replacement.
   Methods: A single center, open-label study with a prospective cohort of patients undergoing primary total knee arthroplasty or total hip arthroplasty treated with closed incision negative pressure therapy (ciNPT) of clean surgical wounds was conducted. One hundred ninety-six incisions treated with ciNPT in 192 patients were compared with a historical control group of 400 patients treated with traditional gauze dressing. The rates of clinically significant hematoma, seroma, dehiscence, surgical site infection, and complication were compared using univariate analyses and multiple logistic regression.
   Results: The rate of deep infection was unchanged in the ciNPT group compared with control (1.0% vs 1.25%); however, the overall rate of infection (including superficial wound infection) decreased significantly (3.5% vs 1.0%, P = .04). Overall complication rate was lower in the ciNPT group than controls (1.5% vs 5.5%, P = .02). Upon logistic regression, only treatment group was associated with complication; patients treated with ciNPT were about 4 times less likely to experience a surgical site complication compared with control (P = .0277, odds ratio 4.251, 95% confidence interval 1.172-15.414).
   Conclusion: ciNPT for total knee arthroplasty and total hip arthroplasty in a comprehensive patient population reduced overall incidence of complication, but did not significantly impact the rate of deep infection. Further research to determine clinical and economic advantages of routine use of ciNPT in total joint arthroplasty is warranted. (c) 2017 Elsevier Inc. All rights reserved.
C1 [Redfern, Roberta E.] ProMed Toledo Hosp, ProMed Res, Toledo, OH USA.
   [Cameron-Ruetz, Claire] Univ Toledo, Coll Nat Sci & Math, Toledo, OH USA.
   [O'Drobinak, Simone K.; Beer, Karl J.] ProMed Toledo Hosp, Wildwood Orthoped & Spine Inst, Dept Orthoped Surg, 2865 N Reynolds Rd,160, Toledo, OH 43615 USA.
   [Chen, John T.] Bowling Green State Univ, Dept Math & Stat, Bowling Green, OH 43403 USA.
C3 University System of Ohio; University of Toledo; University System of
   Ohio; Bowling Green State University
RP Beer, KJ (通讯作者)，ProMed Toledo Hosp, Wildwood Orthoped & Spine Inst, Dept Orthoped Surg, 2865 N Reynolds Rd,160, Toledo, OH 43615 USA.
OI Redfern, Roberta/0000-0001-9883-2910
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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NR 37
TC 69
Z9 80
U1 0
U2 10
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD NOV
PY 2017
VL 32
IS 11
BP 3333
EP 3339
DI 10.1016/j.arth.2017.06.019
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA FM7DA
UT WOS:000415229700013
PM 28705547
DA 2026-07-24
ER
PT J
AU Ashton, R
   Moledina, J
   Sivakumar, B
   Mellerio, JE
   Martinez, AE
AF Ashton, Rosalind
   Moledina, Jamil
   Sivakumar, Branavan
   Mellerio, Jemima E.
   Martinez, Anna E.
TI Considerations in surgical management of a Buschke-Lowenstein tumor in
   Netherton syndrome: A case report
SO PEDIATRIC DERMATOLOGY
LA English
DT Article
DE ichthyosis; Netherton syndrome; pediatric dermatology; topical negative
   pressure therapy; vacuum assisted closure device
AB Netherton syndrome is an autosomal recessive ichthyosis caused by mutations in SPINK5, with the classic triad of linearis circumflexa, trichorrhexis invaginata, and atopy. There are few reports of surgical management in individuals with Netherton syndrome and clinicians may be reluctant to operate for fear of wound-healing complications. This report describes a pediatric case of a Buschke-Lowenstein tumor of the natal cleft in a patient with Netherton syndrome that had failed to respond to medical management. We reviewed the literature for previous cases of surgery in individuals with Netherton syndrome using MEDLINE and PubMed searches. Our patient underwent surgery to remove the lesion without complication. Using conventional dressings and topical negative-pressure therapy, the wound was managed and healed within a reasonable time frame despite the underlying skin condition. This case indicates that surgery and topical negative-pressure therapy is a safe and reasonable treatment for individuals with Netherton syndrome.
C1 [Ashton, Rosalind] Univ Ottawa, Div Plast Surg, Ottawa, ON, Canada.
   [Moledina, Jamil] St George Hosp, Dept Plast Surg, London, England.
   [Sivakumar, Branavan] Great Ormond St Hosp Sick Children, Dept Plast Surg, London, England.
   [Mellerio, Jemima E.; Martinez, Anna E.] Great Ormond St Hosp Sick Children, Dept Dermatol, London, England.
C3 University of Ottawa; City St Georges, University of London; University
   of London; University College London; Great Ormond Street Hospital for
   Children NHS Foundation Trust; University of London; University College
   London; Great Ormond Street Hospital for Children NHS Foundation Trust
RP Martinez, AE (通讯作者)，Great Ormond St Hosp Sick Children, Dept Dermatol, London, England.
EM anna.martinez@gosh.nhs.uk
RI ; Mellerio, Jemima/G-3681-2012
OI Ashton, Rosalind/0000-0002-5672-6594; Mellerio,
   Jemima/0000-0002-2670-8117
CR Benzon H, 2012, PEDIATR ANESTH, V22, P410, DOI 10.1111/j.1460-9592.2012.03815.x
   Di WL, 2011, HARPERS TXB PEDIAT D
   Li ALK, 2011, J PLAST RECONSTR AES, V64, P1533, DOI 10.1016/j.bjps.2011.03.013
   Wirsching KEC, 2013, BMC EAR NOSE THROAT, V13, DOI 10.1186/1472-6815-13-7
NR 4
TC 10
Z9 10
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-8046
EI 1525-1470
J9 PEDIATR DERMATOL
JI Pediatr. Dermatol.
PD NOV-DEC
PY 2017
VL 34
IS 6
BP E328
EP E330
DI 10.1111/pde.13292
PG 3
WC Dermatology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Pediatrics
GA FM8PG
UT WOS:000415350800010
PM 29144034
DA 2026-07-24
ER
PT J
AU Lee, K
   Murphy, PB
   Ingves, MV
   Duncan, A
   DeRose, G
   Dubois, L
   Forbes, TL
   Power, A
AF Lee, Kevin
   Murphy, Patrick B.
   Ingves, Matthew V.
   Duncan, Audra
   DeRose, Guy
   Dubois, Luc
   Forbes, Thomas L.
   Power, Adam
TI Randomized clinical trial of negative pressure wound therapy for
   high-risk groin wounds in lower extremity revascularization
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 37th Annual Meeting of the Canadian-Society-for-Vascular-Surgery (CSVS)
CY SEP 25-26, 2015
CL Victoria, CANADA
SP Canadian Soc Vasc Surg
ID SURGICAL SITE INFECTIONS; VASCULAR-SURGERY; CLASSIFICATION; INCISIONS;
   NSQIP
AB Objective: The surgical site infection (SSI) rate in vascular surgery after groin incision for lower extremity revascularization can lead to significant morbidity and mortality. This trial was designed to study the effect of negative pressure wound therapy (NPWT) on SSI in closed groin wounds after lower extremity revascularization in patients at high risk for SSI.
   Methods: A single-center, randomized, controlled trial was performed at an academic tertiary medical center. Patients with previous femoral artery surgical exposure, body mass index of > 30 kg/m(2) or the presence of ischemic tissue loss were classified as a high-risk patient for SSI. All wounds were closed primarily and patients were randomized to either NPWT or standard dressing. The primary outcome of the trial was postoperative 30-day SSI in the groin wound. The secondary outcomes included 90-day SSI, hospital duration of stay, readmissions or reoperations for SSI, and mortality.
   Results: A total of 102 patients were randomized between August 2014 and December 2015. Patients were classified as at high risk owing to the presence of previous femoral artery cut down (29%), body mass index of > 30 kg/m(2) (39%) or presence of ischemic tissue loss (32%). Revascularization procedures performed included femoral to distal artery bypass (57%), femoral endarterectomy (18%), femoral to femoral artery crossover (17%), and other procedures (8%). The primary outcome of 30-day SSI was 11% in NPWT group versus 19% in standard dressing group (P =.24). There was a statistically significant shorter mean duration of hospital stay in the NPWT group (6.4 days) compared with the standard group (8.9 days; P = .01). There was no difference in readmission or reoperation for SSI or mortality between the two groups.
   Conclusions: This study demonstrated a nonsignificant lower rate of groin SSI in high-risk revascularization patients with NPWT compared with standard dressing. Owing to a lower than expected infection rate, the study was underpowered to detect a difference at the prespecified level. The NPWT group did show significantly shorter mean hospital duration of stay compared with the standard dressing group.
C1 [Lee, Kevin; Duncan, Audra; DeRose, Guy; Dubois, Luc; Power, Adam] Western Univ, Dept Surg, Div Vasc Surg, London, ON, Canada.
   [Murphy, Patrick B.; Ingves, Matthew V.] Western Univ, Schulich Sch Med & Dent, Dept Surg, Div Gen Surg, London, ON, Canada.
   [Forbes, Thomas L.] Univ Toronto, Div Vasc Surg, Dept Surg, Toronto, ON, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); University of Toronto
RP Power, A (通讯作者)，Western Univ, Schulich Sch Med & Dent, Dept Vasc Surg, LHSC Victoria Campus 800,Commissioners Rd E, London, ON N6A 5W9, Canada.
EM adam.power@lhsc.on.ca
RI Murphy, Patrick/T-5337-2019
FU Resident Research Grant from Western University
FX Special thanks to Brenda Henry, Victoria Hospital, LHSC (London,
   Ontario, Canada), who provided tremendous help in this study as a wound
   specialist. The study was funded by a Resident Research Grant from
   Western University without any influence on study design, data
   collection, management or any input on publication. Kinetic Concepts Inc
   (San Antonio, Tex) donated all NPWT devices but had no influence on
   study design, data collection, management or any input on publication.
   KL and PM had full access to all the data in the study and takes
   responsibility for the integrity of the data and the accuracy of the
   data analysis.
CR Damrauer SM, 2010, J VASC SURG, V62
   Davenport DL, 2014, J VASC SURG, V60, P1266, DOI 10.1016/j.jvs.2014.05.051
   Dua A, 2014, J VASC SURG, V60, P1635, DOI 10.1016/j.jvs.2014.08.072
   Dumville JC, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003091.pub3
   Giles KA, 2010, ANN VASC SURG, V24, P48, DOI 10.1016/j.avsg.2009.05.003
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   Greenblatt DY, 2008, YMVA, V54, P433
   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
   Inui T, 2015, SEMIN VASC SURG, V28, P201, DOI 10.1053/j.semvascsurg.2016.02.002
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   Kalish JA, 2014, J VASC SURG, V60, P1238, DOI 10.1016/j.jvs.2014.05.012
   Kuy S, 2014, ANN VASC SURG, V28, P53, DOI 10.1016/j.avsg.2013.08.002
   Lawlor DK, 2011, VASC ENDOVASC SURG, V45, P241, DOI 10.1177/1538574411399157
   Matatov T, 2013, J VASC SURG, V57, P791, DOI 10.1016/j.jvs.2012.09.037
   Murphy P, 2015, TRIALS, V16, DOI 10.1186/s13063-015-1026-1
   Ortega G, 2012, J SURG RES, V174, P33, DOI 10.1016/j.jss.2011.05.056
   Ott E, 2013, EPIDEMIOL INFECT, V141, P1207, DOI 10.1017/S095026881200180X
   Ozaki CK, 2015, J VASC SURG, V61, P419, DOI 10.1016/j.jvs.2014.07.034
   Pearson A, 2009, J HOSP INFECT, V73, P296, DOI 10.1016/j.jhin.2009.08.016
   SZILAGYI DE, 1972, ANN SURG, V176, P321, DOI 10.1097/00000658-197209000-00008
   Vogel TR, 2006, YMVA, V51, P122
   Wiseman JT, 2012, J VASC SURG, V62
   Zhang JQ, 2014, J VASC SURG, V59, P1331, DOI 10.1016/j.jvs.2013.12.032
NR 23
TC 84
Z9 92
U1 0
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD DEC
PY 2017
VL 66
IS 6
BP 1814
EP 1819
DI 10.1016/j.jvs.2017.06.084
PG 6
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA FN3UA
UT WOS:000415925300025
PM 28865981
DA 2026-07-24
ER
PT J
AU Nobaek, S
   Rogmark, P
   Petersson, U
AF Nobaek, S.
   Rogmark, P.
   Petersson, U.
TI Negative Pressure Wound Therapy for Treatment of Mesh Infection After
   Abdominal Surgery: Long-Term Results and Patient-Reported Outcome
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Abdominal surgery; mesh; infection; negative pressure wound therapy;
   incisional hernia; patient-reported outcome
ID VACUUM-ASSISTED CLOSURE; VENTRAL HERNIA REPAIR; INCISIONAL
   HERNIORRHAPHY; MANAGEMENT
AB Background and Aims: Treatment of synthetic mesh infections has previously often resulted in mesh explantation. Negative pressure wound therapy has been used in these situations with encouraging results. The aims of this study were to evaluate wound healing, mesh preservation, and patient-reported outcome after negative pressure wound therapy of mesh infections.
   Material and Methods: Medical records of patients treated with negative pressure wound therapy for mesh infection and age-matched mesh-operated controls without postoperative complications were scrutinized in a retrospective study. An abdominal wall complaints questionnaire was used to evaluate patient-reported outcome.
   Results: Of 722 mesh operations performed 2005-2012, negative pressure wound therapy was used for treating postoperative mesh infections in 48 patients. A total of 48 age-matched controls were recruited from patients without wound complications. No differences were found between groups regarding preoperative characteristics. The following peroperative characteristics were significantly more frequent in the negative pressure wound therapy group: emergency operation, dirty/infected surgical field, surgical techniques other than laparoscopic intraperitoneal onlay mesh repair, implantation of more than one mesh, larger mesh size, longer duration of surgery, and mesh not completely covered with anterior rectus fascia. The entire mesh was salvaged in 92%, while four meshes were partly excised. Wounds healed in 88% after a median of 110 (range 3-649) days. In total, 85% in the negative pressure wound therapy group and 75% in the control group answered the questionnaire. There were no significant differences regarding pain, other abdominal wall symptoms, and satisfaction with the final result in favor of the controls.
   Conclusion: No mesh had to be explanted and wound healing was achieved in the majority of patients when negative pressure wound therapy was used for treatment of mesh infections. However, time to healing was long, and numerous procedures were sometimes needed. Positive long-term outcome was more frequently reported among controls.
C1 [Nobaek, S.] Univ Copenhagen, Sch Med Sci, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Rogmark, P.; Petersson, U.] Dept Clin Sci, Malmo, Sweden.
   [Rogmark, P.; Petersson, U.] Lund Univ, Fac Med, Lund, Sweden.
   [Rogmark, P.; Petersson, U.] Skane Univ Hosp Malmo, Dept Surg, S-20502 Malmo, Sweden.
C3 University of Copenhagen; Lund University; Lund University; Skane
   University Hospital
RP Petersson, U (通讯作者)，Skane Univ Hosp Malmo, Dept Surg, S-20502 Malmo, Sweden.
EM ulf.a.petersson@telia.com
CR Aguilar B, 2010, J LAPAROENDOSC ADV S, V20, P249, DOI 10.1089/lap.2009.0274
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
   Baharestani MM, 2011, INT WOUND J, V8, P118, DOI 10.1111/j.1742-481X.2010.00756.x
   Berrevoet F, 2013, HERNIA, V17, P67, DOI 10.1007/s10029-012-0969-3
   Bliziotis IA, 2006, INFECTION, V34, P46, DOI 10.1007/s15010-006-4140-x
   Breuing K, 2010, SURGERY, V148, P544, DOI 10.1016/j.surg.2010.01.008
   Chatzoulis G, 2012, HERNIA, V16, P475, DOI 10.1007/s10029-010-0767-8
   Clay L, 2012, LANGENBECK ARCH SURG, V397, P1219, DOI 10.1007/s00423-012-0932-x
   Cobb WS, 2003, AM SURGEON, V69, P784
   de Vooght A, 2003, PLAST RECONSTR SURG, V112, P1188, DOI 10.1097/01.PRS.0000077233.64957.30
   den Hartog D, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006438.pub2
   Falagas ME, 2005, CLIN MICROBIOL INFEC, V11, P3, DOI 10.1111/j.1469-0691.2004.01014.x
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   Hawn MT, 2011, AM J SURG, V202, P28, DOI 10.1016/j.amjsurg.2010.10.011
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   Paton B Lauren, 2007, Surg Infect (Larchmt), V8, P337
   Petersen S, 2001, EUR J SURG, V167, P453
   Rosen MJ, 2009, AM J SURG, V197, P353, DOI 10.1016/j.amjsurg.2008.11.003
   Steenvoorde P, 2006, OSTOMY WOUND MANAG, V52, P52
   Stremitzer S, 2010, WORLD J SURG, V34, P1702, DOI 10.1007/s00268-010-0543-z
   Tamhankar AP, 2009, SURG-J R COLL SURG E, V7, P316, DOI 10.1016/S1479-666X(09)80010-3
NR 31
TC 18
Z9 24
U1 1
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD DEC
PY 2017
VL 106
IS 4
BP 285
EP 293
DI 10.1177/1457496917690966
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FN5CB
UT WOS:000416023000001
PM 28385111
OA Bronze
DA 2026-07-24
ER
PT J
AU Yücel, M
   Özpek, A
   Basak, F
   Kiliç, A
   Ünal, E
   Yüksekdag, S
   Acar, A
   Bas, G
AF Yucel, Metin
   Ozpek, Adnan
   Basak, Fatih
   Kilic, Ali
   Unal, Ethem
   Yuksekdag, Sema
   Acar, Aylin
   Bas, Gurhan
TI Fournier's gangrene: A retrospective analysis of 25 patients
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Aggressive surgical debridement; Fournier's gangrene; vacuum-assisted
   closure
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; MANAGEMENT; MORTALITY;
   STRATEGIES; PREDICTORS; DIAGNOSIS; THERAPY
AB BACKGROUND: Fournier's gangrene is a surgical emergency that progresses rapidly and insidiously and results in high morbidity and mortality rates unless it is immediately diagnosed and managed. Here we analyze the outcomes of patients who were followed up and treated for Fournier's gangrene.
   METHODS: We conducted a retrospective analysis of the medical data of 25 patients operated on for Fournier's gangrene between January 2010 and June 2015. The diagnosis of Fournier's gangrene was made by performing a physical examination. Patients who had genital, perineal, and perianal tenderness; induration; cyanosis; gangrene; and subcutaneous crepitation were considered as having Fournier's gangrene. Following resuscitation, aggressive surgical debridement was performed and vacuum-assisted closure (VAC) was conducted in addition to debridement in select patient. Repeat debridements were performed as requirement.
   RESULTS: This study included 25 patients. Fourteen patients (56%) were females and 11 (44%) were males. The mean age of the patients was 54.3 years (range: 27-82 years). The mean duration of hospital stay was 21.4 days; the mean number of debridements performed was 2.4. Thirteen patients (52%) had perianal abscesses, and 20 (80%) had diabetes mellitus. All patients underwent extensive debridement; 16 patients (64%) underwent VAC in addition to debridement. Patients undergoing VAC had significantly longer durations of hospital stay and a higher mean number of debridements performed (p=0.004 and p=0.048, respectively). An ostomy was made in one patient, and one patient died.
   CONCLUSION: In Fournier's gangrene, early diagnosis, effective resuscitation, aggressive debridement, and VAC application in suitable cases may reduce the morbidity and mortality rates and the need for an ostomy.
C1 [Yucel, Metin; Ozpek, Adnan; Basak, Fatih; Kilic, Ali; Unal, Ethem; Yuksekdag, Sema; Acar, Aylin] Umraniye Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Bas, Gurhan] Medeniyet Univ, Dept Gen Surg, Fac Med, Istanbul, Turkey.
C3 Istanbul Umraniye Training & Research Hospital; Istanbul Medeniyet
   University
RP Yücel, M (通讯作者)，Adem Yavuz Caddesi 1, TR-34773 Istanbul, Turkey.
EM drmetin69@mynet.com
RI ; BAS, GÜRHAN/MIO-6489-2025; acar, aylin/HJP-4087-2023; OZPEK,
   ADNAN/Q-7864-2018; Basak, Fatih/A-1531-2014; Yucel, Metin/KFS-4904-2024
OI Unal, Ethem/0000-0003-4056-4874; BAS, GÜRHAN/0000-0002-7542-8269; Basak,
   Fatih/0000-0003-1854-7437; acar, aylin/0000-0003-2378-4197; OZPEK,
   ADNAN/0000-0002-2051-256X; 
CR Assenza M, 2011, CLIN TER, V162, pE1
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   Canbaz H, 2010, ULUS TRAVMA ACIL CER, V16, P71
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   Morpurgo E, 2002, SURG CLIN N AM, V82, P1213, DOI 10.1016/S0039-6109(02)00058-0
   Norton KS, 2002, AM SURGEON, V68, P709
   Oguz A, 2015, INT SURG, V100, P934, DOI 10.9738/INTSURG-D-15-00036.1
   Oymaci E, 2014, TURK J SURG, V30, P85, DOI 10.5152/UCD.2014.2512
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   Yanar H, 2006, WORLD J SURG, V30, P1750, DOI 10.1007/s00268-005-0777-3
   Yilmazlar T, 2014, ULUS TRAVMA ACIL CER, V20, P333, DOI 10.5505/tjtes.2014.06870
NR 24
TC 25
Z9 30
U1 0
U2 5
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD SEP
PY 2017
VL 23
IS 5
BP 400
EP 404
DI 10.5505/tjtes.2017.01678
PG 5
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA FN5SA
UT WOS:000416066800008
PM 29052826
OA Bronze
DA 2026-07-24
ER
PT J
AU Lo Torto, F
   Ruggiero, M
   Parisi, P
   Borab, Z
   Sergi, M
   Carlesimo, B
AF Lo Torto, Federico
   Ruggiero, Marco
   Parisi, Paola
   Borab, Zachary
   Sergi, Manuel
   Carlesimo, Bruno
TI The effectiveness of negative pressure therapy on infected wounds:
   preliminary results
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chronic wound; Daptomicin; Negative pressure wound therapy; Vacuum
   Assisted Closure therapy
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; STERNAL
   OSTEOMYELITIS; DAPTOMYCIN; IMPACT
AB Vacuum-assisted closure (VAC) therapy is a sophisticated system that maintains a closed, humid, sterile and isolated environment. Wound infection is considered a relative contraindication. The objective of this study is to extend the indications for VAC therapy to include infected wounds by demonstrating its ability to increase the antibiotic concentration in the damaged and infected tissues. Patients who presented with ulcers infected with daptomycin-sensitive bacteria were eligible to be enrolled in this prospective study. They were given antibiotic therapy with daptomycin with a specific protocol. A biopsy of the lesion was carried out to detect tissue concentration of the drug at time 0. Afterwards, the patients were subjected to VAC therapy. At the end of VAC therapy, a second lesion biopsy was performed and analysed to detect tissue concentration of the drug at time 1. A control group was enrolled in which patients followed the same protocol, but they were treated with traditional dressings. Fisher's exact test was used to compare the two groups. The results highlighted a significant increase in the concentration of antibiotics in the study group tissue; the improvement was sensibly lower in the control group. Statistical differences were not found between the two groups. The preliminary analysis of the data showed an important increase of antibiotic concentration in the tissue after VAC therapy. Despite the encouraging data, it is necessary to broaden the sample of patients and perform the same study with other antibiotics.
C1 [Lo Torto, Federico; Parisi, Paola; Carlesimo, Bruno] Sapienza Univ Rome, UO Plast Reconstruct Surg, P Valdoni Dept Surg, Rome, Italy.
   [Ruggiero, Marco] Policlin Luigi Di Liegro, Rome, Italy.
   [Borab, Zachary] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA.
   [Sergi, Manuel] Univ Teramo, Fac Biosci & Technol Food Agr & Environm, Teramo, Italy.
C3 Sapienza University Rome; Drexel University; University of Teramo
RP Lo Torto, F (通讯作者)，Sapienza Univ Rome, UO Plast Reconstruct Surg, P Valdoni Dept Surg, Policlin Umberto 1, Viale Policlin 155, I-00161 Rome, Italy.
EM federicolotorto@gmail.com
RI Sergi, Manuel/ABC-4334-2020; Torto, Federico/AAY-1852-2021; PARISI,
   PAOLA/ACJ-8116-2022
OI PARISI, PAOLA/0000-0003-2639-2957; Borab, Zachary/0000-0002-6832-9916
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   Liu DH, 2014, CELL BIOCHEM BIOPHYS, V70, P539, DOI 10.1007/s12013-014-9953-0
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   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Sjögren J, 2008, INT WOUND J, V5, P216, DOI 10.1111/j.1742-481X.2007.00371.x
   STAL S, 1983, ANN PLAS SURG, V11, P347, DOI 10.1097/00000637-198310000-00016
   Tarzia V, 2014, INTERACT CARDIOV TH, V19, P70, DOI 10.1093/icvts/ivu101
   Wise R, 2002, ANTIMICROB AGENTS CH, V46, P31, DOI 10.1128/AAC.46.1.31-33.2002
   Yang SL, 2014, WOUND REPAIR REGEN, V22, P548, DOI 10.1111/wrr.12195
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NR 27
TC 24
Z9 25
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2017
VL 14
IS 6
BP 909
EP 914
DI 10.1111/iwj.12725
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO0HN
UT WOS:000416424400003
PM 28198150
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Miranda, LEC
   Miranda, ACG
AF Miranda, Luiz E. C.
   Miranda, Ana C. G.
TI Enteroatmospheric fistula management by endoscopic gastrostomy PEG tube
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal sepsis; Negative pressure wound therapy; Open abdomen;
   Small-bowel fistula; Temporary abdominal closure
AB Management of small-bowel fistulas which are in an open abdomen and have no soft tissue overlay or a fistula tract involves many complications and challenges. Controlling the local leakage of enteric contents has a central role in the success of medical treatment. There are several methods to deal with fistula discharge but unfortunately, the technical solutions only partially address such problems and a definitive management of fistula discharge still remains an insoluble challenge. We describe a simple and cheap method to control fistula leakage by using a percutaneous endoscopic gastrostomy tube.
C1 [Miranda, Luiz E. C.; Miranda, Ana C. G.] Univ Pernambuco, Oswaldo Cruz Hosp, Dept Gen Surg, Rua Arnobio Marques 310, BR-51100130 Recife, PE, Brazil.
C3 Universidade de Pernambuco (UPE)
RP Miranda, LEC (通讯作者)，Univ Pernambuco, Oswaldo Cruz Hosp, Dept Gen Surg, Rua Arnobio Marques 310, BR-51100130 Recife, PE, Brazil.
EM lecmiranda@gmail.com
RI /C-1450-2017
CR Bruhin A, 2014, INT J SURG, V12, P1105, DOI 10.1016/j.ijsu.2014.08.396
   Di Saverio S, 2011, J TRAUMA, V71, P760, DOI 10.1097/TA.0b013e318216e340
   Majercik S, 2012, NUTR CLIN PRACT, V27, P507, DOI 10.1177/0884533612444541
   Meshikhes AWN, 2013, AM J CASE REP, V14, P476, DOI 10.12659/AJCR.889638
   Ozer MT, 2014, INT WOUND J, V11, P22, DOI 10.1111/iwj.12308
   Terzi C, 2014, INT WOUND J, V11, P17, DOI 10.1111/iwj.12288
   Yetisir F, 2014, INT J SURG CASE REP, V5, P385, DOI 10.1016/j.ijscr.2014.04.030
   Yin JY, 2014, NUTR CLIN PRACT, V29, P656, DOI 10.1177/0884533614536587
NR 8
TC 6
Z9 9
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2017
VL 14
IS 6
BP 915
EP 917
DI 10.1111/iwj.12726
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO0HN
UT WOS:000416424400004
PM 28198100
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Boxall, SL
   Carville, K
   Leslie, GD
   Jansen, SJ
AF Boxall, Sharon L.
   Carville, Keryln
   Leslie, Gavin D.
   Jansen, Shirley J.
TI Treatment of anticoagulated patients with negative pressure wound
   therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Anticoagulant; Negative pressure wound therapy; Topical negative
   pressure
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; MULTICENTER
AB There is a paucity of evidence surrounding the use of negative pressure wound therapy (NPWT) in patients receiving anticoagulant medication. Guidelines generally recommend caution regarding the use of NPWT in anticoagulated patients in general, but areas of particular risk are frequently not highlighted. The US Food and Drug Authority (FDA) reported six mortalities between 2009 and 2011 in patients receiving NPWT. These mortalities were associated with the use of NPWT over vascular graft sites. The coagulation status of these patients was not reported. It is the authors' recommendation that guidelines regarding the use of NPWT in anticoagulated patients highlight specific clinical situations of risk, although there is insufficient evidence to support the avoidance of NPWT in anticoagulated patients in general.
C1 [Boxall, Sharon L.; Carville, Keryln; Leslie, Gavin D.] Curtin Univ, Sch Nursing Midwifery & Paramed, Bentley, WA 6102, Australia.
   [Carville, Keryln] Primary Hlth Care & Community Nursing Curtin, Bentley, WA, Australia.
   [Jansen, Shirley J.] Sir Charles Gairdner Hosp, Vasc & Endovasc Surg, Perth, WA, Australia.
   [Jansen, Shirley J.] Univ Western Australia, Crawley, WA, Australia.
   [Jansen, Shirley J.] Curtin Univ, Hlth Sci Res & Grad Studies, Bentley, WA, Australia.
   [Boxall, Sharon L.] Wound Management Innovat Cooperat Res Ctr WMI CRC, West End, Qld, Australia.
C3 Curtin University; Sir Charles Gairdner Hospital; University of Western
   Australia; Curtin University
RP Boxall, SL (通讯作者)，Curtin Univ, Sch Nursing Midwifery & Paramed, Bentley, WA 6102, Australia.
EM sharon.boxall@postgrad.curtin.edu.au
RI Jansen, Shirley/AAU-3889-2021
OI Jansen, Shirley/0000-0001-7781-4748
FU Australian Government's Cooperative Research Centres Program
FX The authors would like to acknowledge the support of the Australian
   Government's Cooperative Research Centres Program. No conflicts of
   interests.
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Canadian Agency for Drugs and Technologies in Health, 2014, NEG PRESS WOUND THER
   de Runz A, 2013, J PLAST RECONSTR AES, V66, pE321, DOI 10.1016/j.bjps.2013.04.037
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   Food and Drugs Administration, 2011, UPD SER COMPL ASS NE
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   Zhang J, 2014, PLAST RECONSTR SURG, V134, P141, DOI 10.1097/PRS.0000000000000275
NR 17
TC 5
Z9 5
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2017
VL 14
IS 6
BP 950
EP 954
DI 10.1111/iwj.12737
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO0HN
UT WOS:000416424400010
PM 28294534
OA Green Submitted, Green Published
DA 2026-07-24
ER
PT J
AU Limongelli, P
   Casalino, G
   Tolone, S
   Brusciano, L
   Docimo, G
   del Genio, G
   Docimo, L
AF Limongelli, Paolo
   Casalino, Giuseppina
   Tolone, Salvatore
   Brusciano, Luigi
   Docimo, Giovanni
   del Genio, Gianmattia
   Docimo, Ludovico
TI Quality of life and scar evolution after negative pressure or
   conventional therapy for wound dehiscence following post-bariatric
   abdominoplasty
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominoplasty; Negative pressure wound therapy; Quality of life; Scar;
   Wound dehiscence
ID VACUUM-ASSISTED CLOSURE; WEIGHT-LOSS; SURGERY; COMPLICATIONS;
   INTERVENTION; IMPACT
AB No studies have examined scars and quality of life after different treatments of wound dehiscence in patients undergoing post-bariatric abdominoplasty. Scars and quality of life of patients with postoperative wound dehiscence managed with negative pressure wound therapy (group A) and conventional wound therapy (group B) were reviewed 6 months after wound healing. Of 38 patients undergoing treatment for wound dehiscence after 203 abdominoplasty, 35 (group A = 14 versus group B = 21) entered the study. Wound healing in group A was significantly faster than group B (P = 0001). Patients (P = 00001) and observers (P = 00001) reported better overall opinions on a scar assessment scale for group A. Better overall quality of life and general health satisfaction were observed in group A (P < 005). A significant correlation was observed between the World Health Organization Quality of Life scores and Patient and Observer Scar Assessment Scale scores (r=-068, P < 00001) in all 35 patients. Negative pressure wound therapy is feasible and effective in patients with wound dehiscence following post-bariatric abdominoplasty. An adequate post-treatment outcome is achieved compared with conventional wound therapy in light of a strong association found between worse patient scar self-assessment and poor overall quality of life, regardless of the received treatment.
C1 [Limongelli, Paolo; Casalino, Giuseppina; Tolone, Salvatore; Brusciano, Luigi; Docimo, Giovanni; del Genio, Gianmattia; Docimo, Ludovico] Univ Naples 2, Dept Med Surg Neurol Metab & Aging Sci, Div Gen & Obes Surg 11, Via Luigi Pansini 5, I-80131 Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Limongelli, P (通讯作者)，Univ Naples 2, Dept Med Surg Neurol Metab & Aging Sci, Div Gen & Obes Surg 11, Via Luigi Pansini 5, I-80131 Naples, Italy.
EM paolo.limongelli@unina2.it
RI Casalino, Giuseppe/G-9925-2012; Tolone, Salvatore/AHD-6230-2022; Docimo,
   Ludovico/HHD-0312-2022
OI Tolone, Salvatore/0000-0002-1653-9903; Brusciano,
   Luigi/0000-0003-4112-1282; 
CR Agha-Mohammadi S, 2010, AESTHET PLAST SURG, V34, P617, DOI 10.1007/s00266-010-9522-x
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NR 37
TC 8
Z9 11
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2017
VL 14
IS 6
BP 960
EP 966
DI 10.1111/iwj.12739
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Surgery
GA FO0HN
UT WOS:000416424400012
PM 28247499
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Chiang, IH
   Chang, SC
   Wang, CH
AF Chiang, I-Han
   Chang, Shun-Cheng
   Wang, Chih-Hsin
TI Management of necrotising fasciitis secondary to abdominal liposuction
   using a combination of surgery, hyperbaric oxygen and negative pressure
   wound therapy in a patient with burn scars
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Burn scar; Hyperbaric oxygen; Liposuction; Necrotising fasciitis;
   Negative pressure wound therapy
ID VACUUM ASSISTED CLOSURE
AB Liposuction is the one of the most frequently performed cosmetic operations and usually has an easy recovery, with a reportedly low overall complication rate. Here, we report the case of a 60-year-old woman with type II diabetes mellitus and a previous burn injury of the abdomen who underwent abdominal liposuction and subsequently developed necrotising fasciitis. Following radical debridement, systemic antibiotic administration, negative pressure wound therapy and hyperbaric oxygen therapy, the wound healed completely. This case demonstrates the success of the combination treatment and highlights the need for clinicians to be aware of the risk of serious complications in selected patients.
C1 [Chiang, I-Han; Wang, Chih-Hsin] Triserv Gen Hosp, Div Plast & Reconstruct Surg, Dept Surg, Natl Def Med Ctr, Taipei, Taiwan.
   [Chang, Shun-Cheng] Shuang Ho Hosp, Div Plast & Reconstruct Surg, Dept Surg, Hyperbar Oxygen Therapy Ctr, Taipei, Taiwan.
   [Chang, Shun-Cheng] Taipei Med Univ, Sch Med, Dept Surg, Coll Med, Taipei, Taiwan.
C3 National Defense Medical University; Tri-Service General Hospital;
   Taipei Medical University; Shuang Ho Hospital; Taipei Medical University
RP Wang, CH (通讯作者)，Triserv Gen Hosp, Dept Surg, Div Plast Surg & Reconstruct Surg, 325,Sec 2,Cheng Kung Rd, Taipei 114, Taiwan.
EM super-derrick@yahoo.com.tw
CR [Anonymous], COCHRANE DATABASE SY, DOI DOI 10.1002/14651858.CD007937.PUB2
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NR 14
TC 7
Z9 8
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2017
VL 14
IS 6
BP 989
EP 992
DI 10.1111/iwj.12745
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO0HN
UT WOS:000416424400017
PM 28414861
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Lo Torto, F
   Monfrecola, A
   Kaciulyte, J
   Ciudad, P
   Casella, D
   Ribuffo, D
   Carlesimo, B
AF Lo Torto, Federico
   Monfrecola, Ambra
   Kaciulyte, Juste
   Ciudad, Pedro
   Casella, Donato
   Ribuffo, Diego
   Carlesimo, Bruno
TI Preliminary result with incisional negative pressure wound therapy and
   pectoralis major muscle flap for median sternotomy wound infection in a
   high-risk patient population
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Deep sternal wound infection; Pectoralis major muscle flap; Prevena
ID MYOCUTANEOUS ADVANCEMENT FLAPS; SURGICAL INCISIONS; MANAGEMENT-SYSTEM;
   CARDIAC-SURGERY; COMPLICATIONS; MORTALITY; MEDIASTINITIS; CLOSURE; COST
AB Deep sternal wound infection (DSWI) represents a dangerous complication that can follow open-heart surgery with median sternotomy access. Muscle flaps, such as monolateral pectoralis major muscle flap (MPMF), represent the main choices for sternal wound coverage and infection control. Negative pressure incision management system has proven to be able to reduce the incidence of these wounds' complications. Prevena represents one of these incision management systems and we aimed to evaluate its benefits. A total of 78 patients with major risk factors that presented post-sternotomy DSWI following cardiac surgery was selected. Thrity patients were treated with MPMF and Prevena (study group). Control group consisted of 48 patients treated with MPMF and conventional wound dressings. During the follow-up period, 4 (13%) adverse events occurred in the study group, whereas 18 complications occurred (375%) in the control group. Surgical revision necessity and mean postoperative time spent in the intensive care unit were both higher in the control group. Our results evidenced Prevena system's ability in improving the outcome of DSWI surgical treatment with MPMF in a high-risk patient population.
C1 [Lo Torto, Federico; Monfrecola, Ambra; Kaciulyte, Juste; Casella, Donato; Ribuffo, Diego; Carlesimo, Bruno] Sapienza Univ Rome, Dept Surg P Valdoni, Unit Plast & Reconstruct Surg, Rome, Italy.
   [Ciudad, Pedro] China Med Univ Hosp, Dept Plast Surg, Taichung, Taiwan.
C3 Sapienza University Rome; China Medical University Taiwan; China Medical
   University Hospital - Taiwan
RP Kaciulyte, J (通讯作者)，Sapienza Univ Rome, Unit Plast & Reconstruct Surg, Dept Surg P Valdoni, Viale Unita Italia 6, I-02032 Fara In Sabina, RI, Italy.
EM justekc@gmail.com
RI Torto, Federico/AAY-1852-2021; RIBUFFO, Diego/HLG-3305-2023
OI RIBUFFO, Diego/0000-0002-1844-7850
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NR 32
TC 23
Z9 23
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2017
VL 14
IS 6
BP 1335
EP 1339
DI 10.1111/iwj.12808
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO0HN
UT WOS:000416424400059
PM 28901717
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hong, KS
   Yi, HJ
   Lee, RA
   Kim, KH
   Chung, SS
AF Hong, Kyung Sook
   Yi, Hee Jung
   Lee, Ryung-Ah
   Kim, Kwang Ho
   Chung, Soon Sup
TI Prognostic factors and treatment outcomes for patients with Fournier's
   gangrene: a retrospective study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Fournier's gangrene; soft tissue infection; negative-pressure wound
   therapy
ID NECROTIZING FASCIITIS; MALE GENITALIA; MANAGEMENT; MORTALITY; PERINEUM
AB Fournier's gangrene is a gas-forming, necrotising soft tissue infection affecting the perineum. It spreads rapidly along the deep fascial planes and is associated with a high mortality rate. With a growing elderly population with comorbidities, the frequency of severe cases of Fournier's gangrene is expected to increase. We retrospectively reviewed 20 patients diagnosed with Fournier's gangrene at our institution from 2003 to 2014 and analysed data. Thirteen patients had diabetes mellitus, two had been diagnosed with liver cirrhosis, and four were chronic alcoholics. Of 15 patients admitted to an intensive care unit, 11 underwent colostomy, and 4 required skin grafts for wound healing. The wide wounds of two patients were healed using vacuum-assisted closure (VAC((R))) dressing without additional surgery. The mortality rate was 25%, and the patients whose Fournier's gangrene severity index (FGSI) score was higher than 9 points or whose blood urea nitrogen (BUN) level was higher than 50 mg/dl had a poor prognosis. In order to treat Fournier's gangrene, aggressive surgical treatment, including wide debridement and stoma creation, should be considered as soon as possible to improve survival rates. Additionally, VAC dressing is helpful in healing the wide debridement wound without additional reconstructive surgery.
C1 [Hong, Kyung Sook] Ewha Womans Univ, Dept Surg & Crit Care Med, Coll Med, Seoul, South Korea.
   [Yi, Hee Jung; Lee, Ryung-Ah; Kim, Kwang Ho; Chung, Soon Sup] Ewha Womans Univ, Dept Surg, Coll Med, 1071 Anyangcheon Ro, Seoul 07985, South Korea.
C3 Ewha Womans University; Ewha Womans University
RP Chung, SS (通讯作者)，Ewha Womans Univ, Dept Surg, Coll Med, 1071 Anyangcheon Ro, Seoul 07985, South Korea.
EM colonclinic@ewha.ac.kr
RI Hong, Kyung Sook/AAX-7067-2021
OI Hong, Kyung Sook/0000-0002-8022-5693
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NR 31
TC 48
Z9 59
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2017
VL 14
IS 6
BP 1352
EP 1358
DI 10.1111/iwj.12812
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO0HN
UT WOS:000416424400062
PM 28944569
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Rand, BCC
   Wenke, JC
AF Rand, Ben C. C.
   Wenke, Joseph C.
TI An Effective Negative Pressure Wound Therapy-Compatible Local Antibiotic
   Delivery Device
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE open fracture; infection; negative pressure wound therapy; augmented
   NPWT; local antibiotic delivery
ID VACUUM-ASSISTED CLOSURE; CHITOSAN SPONGES; OPEN FRACTURES; COMBAT;
   MODEL; VANCOMYCIN; EXPERIENCE; INJURIES; OUTCOMES; BEADS
AB Objectives: The current clinical standard for local antibiotic depot is polymethylmethacrylate (PMMA) beads. Unfortunately, these are not ideal and negative pressure wound therapy (NPWT) reduces their limited effectiveness. Recently, a chitosan sponge has been shown to be an effective carrier of antibiotics. Because it acts as a delivery vehicle with increased wound contact area instead of an antibiotic depot, it may be more effective. The objectives of this study were to determine if (1) a chitosan sponge would be more effective than PMMA beads as a local antibiotic delivery device and (2) the chitosan sponge remains an effective method of delivery when used in conjunction with NPWT.
   Methods: Contaminated musculoskeletal wounds were created on the proximal tibia of goats; the animals were assigned to 1 of 4 groups (bead pouch, beads with NPWT, sponge pouch, and sponge with NPWT). The animals were survived for 48 hours, and the bacteria in the wound were quantified. The antibiotic levels in the blood and within the NPWT canisters were measured throughout the study period.
   Results: After treatment, there were significantly fewer bacteria in wounds treated with antibiotic chitosan sponge delivery than antibiotic PMMA bead depot (P < 0.05), and NPWT did not reduce the effectiveness of the chitosan sponge even though large amounts of vancomycin was found in the canisters. The peak serum levels of vancomycin were well below what is considered safe levels.
   Conclusions: Antibiotic delivery to the wound using a chitosan sponge is compatible with NPWT and is more effective than PMMA antibiotic depot. The chitosan sponge works in conjunction with NPWT and may improve the outcomes of open fracture wounds.
C1 [Rand, Ben C. C.; Wenke, Joseph C.] US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
   [Rand, Ben C. C.] Royal Ctr Def Med, Acad Dept Mil Surg, Birmingham, W Midlands, England.
C3 Royal Centre for Defence Medicine
RP Wenke, JC (通讯作者)，US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM joseph.c.wenke.civ@mail.mil
FU Bionova Medical (Germantown, TN); US Army Medical Research and Materiel
   Command Combat Casualty Care Research Program
FX The institution of one or more of the authors (J.C.W.) has received
   funding from Bionova Medical (Germantown, TN) who provided the
   experimental materials and paid for a portion of the study. The majority
   of the study was paid for by intramural funding from the US Army Medical
   Research and Materiel Command Combat Casualty Care Research Program.
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NR 22
TC 10
Z9 12
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD DEC
PY 2017
VL 31
IS 12
BP 631
EP 635
DI 10.1097/BOT.0000000000000988
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA FO2QV
UT WOS:000416625900012
PM 28742785
DA 2026-07-24
ER
PT J
AU Castellanos, G
   Bernabé-García, A
   Moraleda, JM
   Nicolás, FJ
AF Castellanos, Gregorio
   Bernabe-Garcia, Angel
   Moraleda, Jose M.
   Nicolas, Francisco J.
TI Amniotic membrane application for the healing of chronic wounds and
   ulcers
SO PLACENTA
LA English
DT Article
DE Amniotic membrane; Wound healing; Chronic wounds; TGF-beta; Cell
   migration; Negative pressure therapy
ID GROWTH-FACTOR-BETA; VACUUM-ASSISTED CLOSURE; TRANSFORMING
   GROWTH-FACTOR-BETA-1; CONDITIONED MEDIUM; BED PREPARATION; C-JUN; CELLS;
   TRANSPLANTATION; AP-1; FIBRONECTIN
AB Wound healing usually follows a predictable sequence and prognosis of events. Its evolutionary process is the result of a complicated interaction between patient-related factors, the wound, the treatment used and the skills and knowledge of the professionals who treat them. Only through a meticulous initial assessment of the wound is it possible to identify the factors that contribute to its complexity. The challenge for professionals will be to implement efficient therapies at the right time and in the most costefficient way in order to reduce associated problems, treat the symptoms and expectations of the patients and achieve adequate wound healing whenever possible. This is particularly evident in big chronic wounds with considerable tissue loss, which become senescent in the process of inflammation or proliferation losing the ability to epithelialize. Generally, chronic wounds do not respond to current treatments, therefore they need special interventions. AM is a tissue of particular interest as a biological dressing and it has well-documented reepithelialization effects which are in part related to its capacity to synthesize and release biological active factors. Our studies have demonstrated that amniotic membrane (AM) is able to induce epithelialization in chronic wounds that were unable to epithelialize. AM induces several signaling pathways that are involved in cell migration and/or proliferation. Additionally, AM is able to selectively antagonize the anti-proliferative effect of transforming growth factor-alpha (TGF-beta) by modifying the genetic program that TGF-beta induces on keratinocytes. The combined effect of AM on keratinocytes, promoting cell proliferation/migration and antagonizing the effect of TGF-beta is the perfect combination, allowing chronic wounds to move out of their non-healing state and progress into epithelialization. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Castellanos, Gregorio] Virgen de la Arrixaca Univ Clin Hosp, Surg Serv, Murcia, Spain.
   [Bernabe-Garcia, Angel; Nicolas, Francisco J.] Virgen de la Arrixaca Univ Clin Hosp, Mol Oncol & TGF, Res Unit, Murcia, Spain.
   [Moraleda, Jose M.] Virgen de la Arrixaca Univ Clin Hosp, Cell Therapy Unit, Murcia, Spain.
C3 Hospital Clinico Universitario Virgen de la Arrixaca; Hospital Clinico
   Universitario Virgen de la Arrixaca; Hospital Clinico Universitario
   Virgen de la Arrixaca
RP Nicolás, FJ (通讯作者)，Virgen de la Arrixaca Univ Clin Hosp, Crta Madrid Cartagena S-N, Murcia 30120, Spain.
EM franciscoj.nicolas2@carm.es
RI Nicolás, Francisco José/H-9422-2019; Moraleda, Jose M/AAB-4119-2020;
   Bernabé-García, Ángel/AAB-2934-2020
OI Nicolás, Francisco José/0000-0002-3969-1430; Moraleda, Jose
   M/0000-0001-9080-1466; Bernabé-García, Ángel/0000-0002-2266-5949
FU Fundacion Seneca de la Region de Murcia [12035/PI/09]; Instituto de
   Salud Carlos III; Fondo de Investigaciones Sanitarias; Instituto de
   Salud Carlos III-Subdireccion General de Evaluacion y Fomento de la
   Investigacion [PI13/00794]; Fondos FEDER (ERDF funds) [EC10-019];
   Hospital Clinico Universitario Virgen de la Arrixaca
FX We would like to thank other members of the different laboratories who
   contribute in our dailytask of increasing our knowledge of AM and
   chronic wound healing. Ana M Garcia, Maria D. Lopez and Monica Rodriguez
   working in the clean room and providing AM. Paola Romencin, Jose E.
   Millan, David Garcia and Noemi Marin, working on AM and animal models,
   and Miguel Blanquer, working in the cell therapy group. Antonio Pinero
   working in the general and digestive system surgery. Antonia Alcaraz,
   Catalina Ruiz-Canada, Ania Mrowiec, Eva M. Garcia, and Sergio Liarte
   working on molecular aspects of AM and wound healing using cell models.
   This work was supported by a grant from the Fundacion Seneca de la
   Region de Murcia (Grant no.: 12035/PI/09) and a grant from the Instituto
   de Salud Carlos III, Fondo de Investigaciones Sanitarias. Plan Estatal
   I+D+i and the Instituto de Salud Carlos III-Subdireccion General de
   Evaluacion y Fomento de la Investigacion (Grant no.: PI13/00794)
   http://www.isciii.es/Fondos FEDER (ERDF funds)
   http://ec.europa.eu/regional_policy/es/funding/erdf/ (Grant no.:
   EC10-019). We are indebted to the Hospital Clinico Universitario Virgen
   de la Arrixaca for stronglysupporting this research.
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NR 109
TC 85
Z9 94
U1 0
U2 12
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0143-4004
EI 1532-3102
J9 PLACENTA
JI Placenta
PD NOV
PY 2017
VL 59
BP 146
EP 153
DI 10.1016/j.placenta.2017.04.005
PG 8
WC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
GA FO3ID
UT WOS:000416720100021
PM 28413063
DA 2026-07-24
ER
PT J
AU Ciuntu, BM
   Georgescu, SO
   Cirdeiu, C
   Timofte, D
   Azoicai, D
   Tecuceanu, A
   Moraru, DC
   Schaas, C
   Blaj, M
   Tamas, C
AF Ciuntu, Bogdan Mihnea
   Georgescu, Stefan Octavian
   Cirdeiu, Ciprian
   Timofte, Daniel
   Azoicai, Doina
   Tecuceanu, Angela
   Moraru, Dan Cristian
   Schaas, Carmina
   Blaj, Mihaelau
   Tamas, Camelia
TI Negative Pressure Therapy in Wounds Surgical Treatment
SO REVISTA DE CHIMIE
LA English
DT Article
DE negative pressure; wounds treatment
ID EXPERIMENTAL DIABETES-MELLITUS
AB The study aims to assess the significance of negative pressure therapy in the treatment of 1 January 2014 31 June 2017. The objectives intend to evaluate the healing time required after applying the method and the functional consequences for the patient. A prospective study was conducted on a sample of 31 patients with various tipe of wounds which were monitored their clinical course between September 2014- February 2017, following negative pressure therapy. There were used vacuum assisted closure devices (VAC (TM) Hartman) in order to apply negative pressure to the wound, while complying with specified settings in accordance with patients' outcome. Healing was obtained in all cases, to an average hospital stay of 30 days and 12 days of therapy application. The negative result of microbial cultures was obtained after an average of 7.55 days by simultaneous application of negative pressure and antibiotic treatment according to the antibiogram. After basic treatment of the wound, auxiliary methods such as negative pressure contribute to the healing. Evolution was favorable with wound granulation in 95% cases, which allowed surgery under local anesthesia, and defect was covered with skin graft. VAC therapy falls into the last group of treatments by eliminating healing inhibitors. This regenerates the wound in a damp environment and essentially turns an open wound into a closed system.
C1 [Ciuntu, Bogdan Mihnea; Georgescu, Stefan Octavian; Cirdeiu, Ciprian; Timofte, Daniel] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Dept Surg, 16 Univ Str, Iasi 700115, Romania.
   [Azoicai, Doina] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Dept Prevent Med & Inderdisciplinar, 16 Univ Str, Iasi 700115, Romania.
   [Tecuceanu, Angela; Moraru, Dan Cristian; Tamas, Camelia] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Plast & Reconstruct Surg Clin, 16 Univ Str, Iasi 700115, Romania.
   [Schaas, Carmina] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Obstet & Gynecol Cuza Voda Hosp Iasi, 16 Univ Str, Iasi 700115, Romania.
   [Blaj, Mihaelau] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Anesthesia & Intens Care, 16 Univ Str, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy
RP Ciuntu, BM (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Dept Surg, 16 Univ Str, Iasi 700115, Romania.; Tamas, C (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Plast & Reconstruct Surg Clin, 16 Univ Str, Iasi 700115, Romania.
EM bogdanmciuntu@yahoo.com; camelia6ta@yahoo.com
RI Ciuntu, Bogdan/MTF-9477-2025; AZOICAI, DOINA/HDO-6161-2022; Timofte,
   Daniel/AAE-2511-2019; Tamas, Camelia/IAO-9797-2023
OI AZOICAI, DOINA/0000-0003-0423-4085; Timofte, Daniel/0000-0002-6604-874X;
   
CR Adamkova M, 2005, Acta Chir Plast, V47, P24
   Badescu L, 2012, ROM BIOTECH LETT, V17, P7397
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   Filip CI, 2017, MATER PLAST, V54, P414
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   Mocanu M, 2015, REV CHIM-BUCHAREST, V66, P997
   Potter MJ, 2008, BURNS, V34, P164, DOI 10.1016/j.burns.2007.06.020
NR 16
TC 7
Z9 7
U1 0
U2 14
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD NOV
PY 2017
VL 68
IS 11
BP 2687
EP 2690
PG 4
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA FO3RW
UT WOS:000416751800046
DA 2026-07-24
ER
PT J
AU Li, P
   Han, X
   Sun, ML
   Liu, WC
   Chen, Q
   Zhou, XL
   Yu, GN
   Liu, Y
   Li, Q
AF Li, Ping
   Han, Xue
   Sun, Mingliang
   Liu, Wenchi
   Chen, Qing
   Zhou, Xinli
   Yu, Guina
   Liu, Yan
   Li, Qiu
TI Improved vacuum-assisted closure therapy for diabetic wounds that were
   difficult to heal and accompanied by chronic narrow sinus: a case series
   of five patients
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Vacuum-assisted closure therapy; diabetic wounds; chronic narrow sinus
ID FOOT ULCERS; MANAGEMENT; CONSENSUS
AB Objective: To investigate the efficacy of improved vacuum-assisted closure (VAC) therapy for diabetic wounds that are difficult to heal because of the presence of chronic narrow sinuses or cavities. Methods: Five patients met the inclusion criteria and were selected from the Department of Endocrinology, Shandong Provincial Hospital, affiliated to Shandong University. All the patients received improved negative-pressure wound therapy (NPWT) in addition to standard-of-care treatment. We completed intra-subject comparisons of wound growth speed [(the last depth - the depth of the wound)/interval number (mm/day)] to determine treatment effectiveness. Patients were followed up until healing. We recorded visual representations of wound progression and time to full healing. Results: All the subjects demonstrated variable degrees of improvement of wound healing at the last follow-up. Wound healing during NPWT was significantly faster than that observed during standard-of-care treatment. Conclusion: The improved VAC therapy promoted narrow fistula healing in the patients with refractory diabetic foot wounds, but the promotion and application of this technology require additional research.
C1 [Li, Ping; Liu, Wenchi; Chen, Qing; Zhou, Xinli; Yu, Guina; Li, Qiu] Shandong Univ, Shandong Prov Hosp, Dept Endocrinol, Jinan, Shandong, Peoples R China.
   [Han, Xue] Nanjing Univ Tradit Chinese Med, Jiangsu Prov Hosp Integrat Chinese & Western Med, China Acad Chinese Med Sci, Endocrine & Diabet Ctr,Jiangsu Branch, Nanjing, Jiangsu, Peoples R China.
   [Sun, Mingliang] Shandong Univ Tradit Chinese Med, Jinan, Shandong, Peoples R China.
   [Liu, Yan] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Dept Endocrinol, Jinan, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Nanjing University of Chinese Medicine;
   China Academy of Chinese Medical Sciences; Shandong University of
   Traditional Chinese Medicine; University of Jinan; Shandong First
   Medical University & Shandong Academy of Medical Sciences
RP Li, Q (通讯作者)，Shandong Univ, Shandong Prov Hosp, Dept Endocrinol, Jinan, Shandong, Peoples R China.
EM liqiu10@163.com
RI sun, Mingliang/LFT-0587-2024; /R-4468-2019
CR Albuquerque MLC, 2000, AM J PHYSIOL-HEART C, V279, pH293, DOI 10.1152/ajpheart.2000.279.1.H293
   Amer Diabet Assoc, 2013, DIABETES CARE, V36, P1033, DOI 10.2337/dc12-2625
   Andros G, 2006, OSTOMY WOUND MANAG, P1
   [Anonymous], 2005, TIM ACT DIAB FOOT CA
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NR 26
TC 1
Z9 1
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 11
BP 15229
EP 15236
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FO5IA
UT WOS:000416885900026
DA 2026-07-24
ER
PT J
AU Meybodi, F
   Sedaghat, N
   French, J
   Keighley, C
   Mitchell, D
   Elder, E
AF Meybodi, Farid
   Sedaghat, Negin
   French, James
   Keighley, Caitlin
   Mitchell, David
   Elder, Elisabeth
TI Implant salvage in breast reconstruction with severe peri-prosthetic
   infection
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE breast implant; breast reconstruction; infection
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; NEGATIVE-PRESSURE;
   IN-VITRO; MANAGEMENT; INSTILLATION; STRATEGIES; EXPANDER; IMPACT
AB BackgroundAlthough treatment of mild peri-prosthetic infection in implant-based breast reconstruction results in high rates of resolution, successful management of severe peri-prosthetic infection remains a significant challenge.
   MethodsIn this case series, a protocol utilizing a novel dressing - negative pressure wound therapy with instillation (NPWTi) - for the management of severe peri-prosthetic infection in breast reconstruction patients is described. This is an operative technique involving: (i) explantation of the breast prosthesis and application of the NPWTi dressing to the implant pocket; (ii) change of the NPWTi dressing; (iii) intraoperative fluid/tissue cultures; and (iv) reimplantation of the breast prosthesis when cultures yield no growth.
   ResultsThis protocol was utilized in six cases of severe peri-prosthetic infection in five patients with immediate breast reconstruction for breast cancer or risk-reducing surgery. Cultures of fluid/tissue grew typical and/or unusual organisms. Only one case did not yield an organism. The hospital length of stay upon completion of the protocol ranged from 7-16 days (mean, 12 days). Successful implant salvage was achieved in five of six cases. The protocol was aborted in one case to allow for completion of adjuvant chemotherapy.
   ConclusionsEarly findings from this case series suggest that in cases of severe peri-prosthetic infection this novel operative protocol may result in successful implant salvage for breast reconstruction patients. Further studies are needed to more fully elaborate the role of NPWTi to achieve implant salvage in challenging cases of peri-prosthetic infection.
C1 [Meybodi, Farid; Sedaghat, Negin; French, James; Elder, Elisabeth] Westmead Hosp, Westmead Breast Canc Inst, Sydney, NSW, Australia.
   [Keighley, Caitlin; Mitchell, David] Westmead Hosp, Ctr Infect Dis & Microbiol, Sydney, NSW, Australia.
C3 NSW Health; Westmead Hospital; University of Sydney; University of
   Sydney; NSW Health; Westmead Hospital
RP Meybodi, F (通讯作者)，Westmead Breast Canc Inst, POB 143, Westmead, NSW 2145, Australia.
EM faridmey@gmail.com
RI Sedaghat, Negin/AAX-4453-2021; Elder, Elisabeth/ABS-2803-2022
OI Elder, Elisabeth/0000-0002-6686-9898; Keighley,
   Caitlin/0000-0002-8892-3488
CR Andriessen AE, 2008, WOUNDS, V20, P171
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NR 29
TC 23
Z9 25
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD DEC
PY 2017
VL 87
IS 12
BP E293
EP E299
DI 10.1111/ans.13379
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FO9IR
UT WOS:000417201700013
PM 26572237
DA 2026-07-24
ER
PT J
AU Evran, M
   Sert, M
   Tetiker, T
   Akkus, G
   Biçer, ÖS
AF Evran, Mehtap
   Sert, Murat
   Tetiker, Tamer
   Akkus, Gamze
   Bicer, Omer Sunkar
TI Spontaneous calcaneal fracture in patients with diabetic foot ulcer:
   Four cases report and review of literature
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Review
DE Diabetes mellitus; Foot ulcer; Calcaneal fracture
ID BONE-MINERAL DENSITY; OPERATIVE TREATMENT; CHARCOT FOOT; OSTEOMYELITIS;
   NEUROARTHROPATHY
AB Spontaneous calcaneal fractures in diabetic patients without obvious trauma may occur, sometimes accompanying diabetic foot ulcers. In the current study we report four cases who were hospitalized for diabetic foot ulcer with concomitant calcaneal fractures. There were four diabetic patients (one type 1 and three type 2) who registered with diabetic foot ulcers with coexisting calcaneal fractures, all of which were classified as Type A according to Essex Lopresti Calcaneal Fracture Classification. Two of the patients with renal failure were in a routine dialysis program, as well as vascular compromise and osteomyelitis in all of the patients. The diabetic foot ulcer of the 61 years old osteoporotic female patient healed with local debridement, vacuum assisted closure and then epidermal growth factor while the calcaneal fracture was then followed by elastic bandage. In two patients could not prevent progression of diabetic foot ulcers and calcaneal fractures to consequent below-knee amputation. The only patient with type 1 diabetes mellitus improved with antibiotic therapy and split thickness skin grafting, while the calcaneal fracture did not heal. In the current study we aimed to emphasize the spontaneous calcaneal fractures as possible co-existing pathologies in patients with diabetic foot ulcers. After all the medical treatment, amputation below knee had to be performed in 2 patients. It should be noted that other accompanying conditions such as impaired peripheral circulation, osteomyelitis, chronic renal failure, and maybe osteoporosis is a challenge of the recovery of calcaneal fractures and accelerate the progress to amputation in diabetic patients.
C1 [Evran, Mehtap; Sert, Murat; Tetiker, Tamer; Akkus, Gamze] Univ Cukurova Adana, Cukurova Univ, Div Endocrinol, Dept Internal Med,Med Fac, TR-01330 Adana, Turkey.
   [Bicer, Omer Sunkar] Univ Cukurova Adana, Cukurova Univ, Med Fac, Dept Orthoped & Traumatol, TR-01330 Adana, Turkey.
C3 Cukurova University; Cukurova University
RP Evran, M (通讯作者)，Univ Cukurova Adana, Cukurova Univ, Med Fac, Endocrinol,Dept Internal Med,Div Endocrinol, TR-01330 Adana, Turkey.
EM mehtap.evran@hotmail.com
RI akkus, gamze/AAJ-7430-2020; Biçer, Ömer/HSF-3996-2023; Evran,
   Mehtap/G-4823-2018; /G-6103-2018
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NR 26
TC 5
Z9 5
U1 0
U2 9
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD JUL 16
PY 2016
VL 4
IS 7
BP 181
EP 186
DI 10.12998/wjcc.v4.i7.181
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FO9UC
UT WOS:000417241100005
PM 27458594
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Yang, D
   Davies, A
   Burge, B
   Watkins, P
   Dissanaike, S
AF Yang, Derek
   Davies, April
   Burge, Bailey
   Watkins, Phillip
   Dissanaike, Sharmila
TI Open-to-Air Is a Viable Option for Initial Wound Care in Necrotizing
   Soft Tissue Infection that Allows Early Detection of Recurrence without
   Need for Painful Dressing Changes or Return to Operating Room
SO SURGICAL INFECTIONS
LA English
DT Article
DE necrotizing fasciitis; necrotizing soft tissue infection; open wound
ID STRESS
AB Background: The standard treatment of necrotizing soft tissue infection (NSTI) includes extensive surgical debridement. Care of these debridements is challenging because of the size of the wound and associated pain. A potential solution is to leave the wounds open-to-air in the period after the initial debridement, allowing for regular inspection at bedside while reducing pain associated with frequent dressing changes. We evaluated the feasibility of this approach from a pain control standpoint. Patients and Methods: An audit of wound care modalities used on adult patients with NSTI admitted to a regional burn center between January 2009 and May 2014 was performed. Patients with at least one operation were included. Those opting for palliative care were excluded. Wound care was divided into four categories: open-to-air (OTA), negative-pressure wound therapy (NPWT), packing, and ointment. Wound care, pain score, pain medication use, and number of operations were collected for the first seven days after initial debridement. Pain management was assessed by pain scores. Analgesic use was measured and compared using conversion to morphine milligram equivalents (MME). Results: Ninety-six patients were included; 67% were men with average age of 50 years, resulting in a total of 672 days of wound care evaluated: 69 days of OTA, 127 days of NPWT, 200 days of packing, and 126 days of ointment (150 days were undocumented). Average daily pain score from all wound care modalities was 2.00. Negative pressure wound therapy had the highest reported daily pain score (2.18, p=0.034), whereas OTA had the lowest pain score (1.63, p<0.05). Mortality was lower in the OTA cohort but was not statistically significant; there were no other differences in long-term outcome. Conclusion: Leaving wounds OTA is a safe and viable option in the immediate post-debridement period of NSTI to reduce pain, while permitting frequent re-evaluation for quick recognition of disease progression and repeat operative debridement if necessary.
C1 [Yang, Derek; Dissanaike, Sharmila] Texas Tech Univ, Hlth Sci Ctr, Sch Med, Dept Surg, Lubbock, TX 79430 USA.
   [Davies, April; Burge, Bailey] Univ Med Ctr, Lubbock, TX USA.
   [Watkins, Phillip] Texas Tech Univ, Hlth Sci Ctr, Clin Res Inst, Lubbock, TX 79430 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center; Texas Tech University System; Texas Tech University Health
   Sciences Center; Texas Tech University System; Texas Tech University
   Health Sciences Center
RP Dissanaike, S (通讯作者)，3601 4th St STOP 8312, Lubbock, TX 79430 USA.
EM sharmila.dissanaike@ttuhsc.edu
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NR 17
TC 5
Z9 5
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD JAN
PY 2018
VL 19
IS 1
BP 65
EP 70
DI 10.1089/sur.2017.080
EA DEC 2017
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA FR9JV
UT WOS:000417296800001
PM 29211657
DA 2026-07-24
ER
PT J
AU Misiakos, EP
   Zabras, N
   Bagias, G
   Tzanetis, P
   Michail, L
   Vasdekis, S
   Patapis, P
   Machairas, A
AF Misiakos, Evangelos P.
   Zabras, Nick
   Bagias, George
   Tzanetis, Panagiotis
   Michail, Lignos
   Vasdekis, Spyros
   Patapis, Paul
   Machairas, Anastasios
TI Uncommon Locations of Gas Gangrene Treated Successfully With Surgical
   Debridement and the Vacuum-Assisted Closure Device
SO INTERNATIONAL SURGERY
LA English
DT Article
DE Gas gangrene; Fournier's gangrene; Debridement; Vacuum-assisted closure
   method
ID NECROTIZING FASCIITIS SERVES; SOFT-TISSUE INFECTIONS;
   FOURNIERS-GANGRENE; DECREASE MORTALITY; RISK-FACTORS; MANAGEMENT;
   STRATEGIES
AB Gas gangrene is a life-threatening condition implying necrosis of dermis and hypodermis, along with necrosis of the superficial muscular aponeurosis. Fournier s gangrene is a subtype of the disease affecting the perineal and genital area. The aim of this study is to analyze the clinical presentation, diagnosis, medical, and surgical treatment of three cases of gas gangrene affecting uncommon locations in the human body, treated with extensive surgical debridement followed by the vacuum assisted closure method in two of these cases. Three cases of gas gangrene affecting uncommon locations treated surgically in our Department are presented. In one case the perineal and scrotal region was infected with invasion of the lateral abdominal wall and the peritoneal cavity. In the second case the axillary regions were infected bilaterally and in the third case the left axillary and subscapular regions were infected after a left arm disarticulation. All cases were treated successfully with successive surgical debridement and/or the vacuum-assisted closure method. Gas gangrene is a curable disease if diagnosed early and treated effectively with successive surgical wound cleaning and debridement. The vacuum assisted closure method can be helpful in promoting wound healing.
C1 [Misiakos, Evangelos P.; Zabras, Nick; Bagias, George; Tzanetis, Panagiotis; Patapis, Paul; Machairas, Anastasios] Univ Athens, Attikon Univ Hosp, Sch Med, Dept Surg 3, Athens, Greece.
   [Michail, Lignos] Univ Athens, Attikon Univ Hosp, Sch Med, Dept Crit Care Med 2, Athens, Greece.
   [Vasdekis, Spyros] Univ Athens, Sch Med, Attikon Univ Hosp, Dept Vasc Surg, Athens, Greece.
C3 University Hospital Attikon; National & Kapodistrian University of
   Athens; National & Kapodistrian University of Athens; University
   Hospital Attikon; National & Kapodistrian University of Athens;
   University Hospital Attikon
RP Misiakos, EP (通讯作者)，Univ Athens, Sch Med, 76 Aigeou Pelagous St, Athens 15341, Greece.
EM misiakos@med.uoa.gr
RI VASDEKIS, SPYROS/G-3740-2010
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU INT COLLEGE OF SURGEONS
PI CHICAGO
PA 1516 N LAKE SHORE DR, CHICAGO, IL 60610 USA
SN 0020-8868
J9 INT SURG
JI Int. Surg.
PD NOV-DEC
PY 2016
VL 101
IS 11-12
BP 517
EP 523
DI 10.9738/INTSURG-D-14-00296.1
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FP3MT
UT WOS:000417523000005
OA hybrid
DA 2026-07-24
ER
PT J
AU Schurtz, E
   Differding, J
   Jacobson, E
   Maki, C
   Ahmeti, M
AF Schurtz, Elleson
   Differding, Jerome
   Jacobson, Eric
   Maki, Christopher
   Ahmeti, Mentor
TI Evaluation of negative pressure wound therapy to closed laparotomy
   incisions in acute care surgery
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID HIGH-RISK
AB Background: Surgical site complications in the form of wound infections are a major burden to the healthcare system. Negative pressure wound therapy (NPWT) as delivered by a surgical incision management system (SIMS) is a novel approach to improve wound healing when applied to closed incisions. However, data is limited in its application to laparotomy incisions in the acute care surgery setting.
   Methods: A retrospective case-control study was performed to evaluate the outcomes of SIMS with regard to surgical site infections in a series of 48 consecutive patients in which SIMS was applied to closed laparotomy incisions in the acute care surgery setting.
   Results: 48 cases were matched with equivalent controls without significant differences between groups. Patients who received the SIMS had significantly lower rates of surgical site infection and readmission rates.
   Conclusions: Negative pressure surgical incision management systems may be a novel approach to reduce surgical site infections in acute care surgery. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Schurtz, Elleson; Maki, Christopher] Univ North Dakota, Sch Med & Hlth Sci, Grand Forks, ND 58202 USA.
   [Differding, Jerome; Jacobson, Eric; Ahmeti, Mentor] Sanford Med Ctr, Fargo, ND USA.
C3 University of North Dakota Grand Forks; Sanford Health
RP Schurtz, E (通讯作者)，Univ North Dakota, Sch Med & Hlth Sci, Grand Forks, ND 58202 USA.
EM eschurtz@gmail.com
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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   National Healthcare Safety Network Centers for Disease Control and Prevention, 2017, Surgical site infection (SSI) event
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   Suh H, 2016, ANN PLAS SURG, V76, P717, DOI 10.1097/SAP.0000000000000231
NR 14
TC 35
Z9 38
U1 0
U2 5
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD JAN
PY 2018
VL 215
IS 1
BP 113
EP 115
DI 10.1016/j.amjsurg.2017.08.009
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FP4SP
UT WOS:000417607000021
PM 28882357
DA 2026-07-24
ER
PT J
AU Smid, MC
   Dotters-Katz, SK
   Grace, M
   Wright, ST
   Villers, MS
   Hardy-Fairbanks, A
   Stamilio, DM
AF Smid, Marcela C.
   Dotters-Katz, Sarah K.
   Grace, Matthew
   Wright, Sarah T.
   Villers, Margaret S.
   Hardy-Fairbanks, Abbey
   Stamilio, David M.
TI Prophylactic Negative Pressure Wound Therapy for Obese Women After
   Cesarean Delivery A Systematic Review and Meta-analysis
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Review
ID SURGICAL SITE INFECTIONS; RANDOMIZED CONTROLLED-TRIAL; EXTREME OBESITY;
   COMPLICATIONS; SECTION; CEFAZOLIN; OUTCOMES
AB OBJECTIVE: To summarize available studies on wound complication outcomes after prophylactic negative pressure wound therapy for obese women (body mass index 30 or greater).
   DATA SOURCES: We conducted a systematic review and meta-analysis using electronic database search (PubMed, Cumulative Index to Nursing and Allied Health Literature, EMBASE, Google scholar, and Web of Science), Cochrane, and trial registries including ClinicalTrials.gov.
   METHODS OF STUDY SELECTION: We conducted an electronic search of research articles from 1966 to January 2017 for randomized controlled trials (RCTs), prospective cohort, and retrospective cohort studies of negative pressure wound therapy compared with standard dressing after cesarean delivery among obese women. Our primary outcome was defined as a composite of wound complication, including wound or surgical site infection, cellulitis, seroma, hematoma, wound disruption, or dehiscence. For cohort studies and RCTs, we performed a descriptive systematic review. For available RCTs, we performed a meta-analysis and pooled risk ratios using a random-effects model. We assessed for heterogeneity using chi(2) test for heterogeneity and I-2 test. We assessed for publication bias using a funnel plot.
   TABULATION, INTEGRATION, AND RESULTS: Of 10 studies meeting eligibility criteria, five were RCTs and five were cohort studies. Results of cohort studies were varied; however, all had a high potential for selection bias. In the meta-analysis, there was no difference in primary composite outcome among those women with negative pressure wound therapy (16.8%) compared with those who had standard dressing (17.8%) (risk ratio 0.97, 95% CI 0.63-1.49). There was no statistically significant heterogeneity (chi(2) test 4.80, P=.31, I-2=17%).
   CONCLUSION: Currently available evidence does not support negative pressure wound therapy use among obese women for cesarean wound complication prevention.
C1 Univ Utah, Dept Obstet & Gynecol, Div Maternal Fetal Med, Salt Lake City, UT USA.
   Univ North Carolina Chapel Hill, Div Maternal Fetal Med, Dept Obstet & Gynecol, Chapel Hill, NC USA.
   Univ North Carolina Chapel Hill, Hlth Sci Lib, Chapel Hill, NC USA.
   Duke Univ, Dept Obstet & Gynecol, Div Maternal Fetal Med, Durham, NC USA.
   Univ Iowa, Div Maternal Fetal Med, Dept Obstet & Gynecol, Iowa City, IA USA.
C3 Utah System of Higher Education; University of Utah; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina School of Medicine; University of North Carolina; University of
   North Carolina Chapel Hill; University of North Carolina School of
   Medicine; Duke University; University of Iowa
RP Smid, MC (通讯作者)，Univ Utah, 30 N 1900 E,2B200, Salt Lake City, UT 84312 USA.
EM Marcela.Smid@hsc.utah.edu
RI ; Grace, Matthew/GYD-4980-2022; Wright, Sarah/P-8166-2016; Wright,
   Sarah/P-8166-2016
OI Hardy-Fairbanks, Abbey/0000-0003-4041-3937; Grace,
   Matthew/0000-0003-3654-0677; Wright, Sarah/0000-0003-2076-8343
CR Ahmadzia H, 2015, AM J OBSTET GYNECOL, V212, pS96
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NR 44
TC 48
Z9 53
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD NOV
PY 2017
VL 130
IS 5
BP 969
EP 978
DI 10.1097/AOG.0000000000002259
PG 10
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FP5HS
UT WOS:000417651200018
PM 29016508
DA 2026-07-24
ER
PT J
AU Ehya, REM
   Zhao, Y
   Zheng, X
   Yi, WR
   Bounda, GA
   Li, ZH
   Xiao, WD
   Yu, AX
AF Ehya, Regis Ernest Mendame
   Zhao, Yong
   Zheng, Xun
   Yi, Wanrong
   Bounda, Guy-Armel
   Li, Zonghuan
   Xiao, Weidong
   Yu, Aixi
TI Comparative effectiveness study between negative pressure wound therapy
   and conventional wound dressing on perforator flap at the Chinese
   tertiary referral teaching hospital
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Traumatic wounds reconstructive closure; Perforator flap; Negative
   pressure wound therapy; Vacuum assisted closure therapy; Conventional
   wound dressing care
ID SKIN-GRAFTS; TRIAL; MANAGEMENT; MECHANISM; DEVICE; BURNS; LEG
AB Background: Perforator flap techniques with conventional wound dressing have being extensively used in the management of soft-tissue defects. However; the flap's survival rate is not always guaranteed and the wound healing time always long. The aim of this study was to investigate the clinical effectiveness use of a freshly transplanted perforator flap in conjunction with Vacuum-assisted closure (VAC) for better clinical outcomes.
   Methods: A prospective, randomized, effectiveness study comparing the clinical outcomes of VAC versus traditional wrap and bandages for the treatment of open wounds that required hospital admission and operative debridement using perforator flaps, was carried out from March 1, 2014 to March 31, 2016 at Wuhan University Zhongnan Hospital. Fifty-one eligible patients were randomized into two groups; study group (perforator flaps covered by VAC) and control group (perforator flaps covered by traditional wrap and bandages). The measured clinical endpoints included the time of the first post-operative dressing change, pain visual analogical scale, perforator flap infection rate, 95% perforator flap healing time and percentage of survived perforator flap.
   Results: There was no statistically significant difference in the demographic profiles in the two cohorts. There were statistically significant differences in the clinical endpoints in the two groups (p < 0.001; p < 0.05, Table 2).
   Conclusions: In summary, VAC combining with perforator flap technique, can diminish accumulated exudation of the transferring flap, protect against postoperative infection, prolong the interval between perforator flap relocation and first postoperative dressing change, decrease pain during removal of dressing, increase perforator flap survival rate, and shorten wound healing time, with a good aesthetic outcome, a good mobility and a satisfactory therapeutic result. (c) 2017 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.
C1 [Ehya, Regis Ernest Mendame; Zhao, Yong; Zheng, Xun; Yi, Wanrong; Li, Zonghuan; Xiao, Weidong; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Hubei, Peoples R China.
   [Bounda, Guy-Armel] China Pharmaceut Univ, Dept Clin Pharm, Sch Basic Med & Clin Pharm, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China.
   [Bounda, Guy-Armel] Sinomedica Co Ltd, 677 Nathan Rd, Kowloon, Hong Kong, Peoples R China.
C3 Wuhan University; China Pharmaceutical University
RP Ehya, REM (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Hubei, Peoples R China.; Yu, AX (通讯作者)，169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM mendameregis@yahoo.fr; yuaixi@whu.edu.cn
RI ; BOUNDA, Guy-Armel/D-3203-2014; Zheng, Xun/JEP-2802-2023
OI Mendame ehya, Regis ernest/0000-0003-3275-6649; BOUNDA,
   Guy-Armel/0000-0002-9237-0484; 
CR Auxenfans C, 2015, BURNS, V41, P71, DOI 10.1016/j.burns.2014.05.019
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NR 35
TC 6
Z9 6
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-206X
J9 J TISSUE VIABILITY
JI J. Viab.
PD NOV
PY 2017
VL 26
IS 4
BP 282
EP 288
DI 10.1016/j.jtv.2017.07.002
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA FP5NC
UT WOS:000417665200009
PM 28734659
DA 2026-07-24
ER
PT J
AU Cecere, F
   Kafka, R
   Maglione, M
   Öfner, D
   Wykypiel, H
AF Cecere, F.
   Kafka, R.
   Maglione, M.
   Oefner, D.
   Wykypiel, H.
TI "The abdominal catastrophe"
SO EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
LA English
DT Article
DE Short bowel syndrome; Intestinal fistula; Parenteral nutrition;
   Intestinal transplant
ID SHORT-BOWEL SYNDROME; PARENTERAL-NUTRITION; MANAGEMENT; TRANSPLANTATION
AB An open abdomen with multiple small intestinal fistulas is a highly challenging situation for the entire treating team and, in some cases, ultimately requires small bowel transplantation.
   In May 2015, a 55-year-old female patient was transferred to our department for evaluation for small bowel transplantation. Following appendectomy in childhood, the patient had had a complicated course with consecutive loss of small bowel. In May 2014, an even more complicated perforated sigma diverticulitis followed. The consequence was a small bowel high-output stoma with concomitant short-bowel syndrome. In March 2015, an attempt to reconstruct the passage failed and ended in an open abdomen with eight small intestinal fistulae, a contracted ileostomy and a defunctioned descendostomy. We firstly mobilized the stoma and conditioned the wound with almost daily changing of a vacuum dressing system (VACA (R), KCI, International) by using a children's pacifier. At 6 months after the previous abdominal operation, extensive adhesiolysis and conglomerate resection plus a jejunoileostomy and new installation of the descendostomy was performed. Approximately 80 cm of small intestine, 50 cm of colon plus the ileocecal valve could be preserved. The abdominal wall was closed cutaneously only. After 168 days of hospitalization, the patient was discharged with oral alimentation and supplementary parenteral nutrition only by night.
   With considerable nursing and surgical effort, the need for intestinal transplantation with all its complications can be avoided in selected cases. A children's pacifier can help to make vacuum-assisted closure of the wound possible.
C1 [Cecere, F.; Kafka, R.; Maglione, M.; Oefner, D.; Wykypiel, H.] Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, Innsbruck, Austria.
C3 Medical University of Innsbruck
RP Cecere, F (通讯作者)，Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, Innsbruck, Austria.
EM federico.cecere@tirol-kliniken.at
RI Öfner, Dietmar/JJF-9514-2023; Maglione, Manuel/AAK-8599-2020
CR Abu-Elmagd KM, 2009, TRANSPLANTATION, V88, P926, DOI 10.1097/TP.0b013e3181b7509c
   [Anonymous], 2000, ACTA CHIRURG AUSTRIA
   [Anonymous], OPTN SRTR 2011 ANN D
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NR 18
TC 0
Z9 0
U1 0
U2 5
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 1682-8631
EI 1682-4016
J9 EUR SURG
JI Eur. Surg.
PD DEC
PY 2017
VL 49
IS 6
BP 293
EP 297
DI 10.1007/s10353-017-0490-0
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FP6HJ
UT WOS:000417725600009
DA 2026-07-24
ER
PT J
AU van der Valk, MJM
   de Graaf, EJR
   Doornebosch, PG
   Vermaas, M
AF van der Valk, Maxime J. M.
   de Graaf, Eelco J. R.
   Doornebosch, Pascal G.
   Vermaas, Maarten
TI Incisional Negative-Pressure Wound Therapy for Perineal Wounds After
   Abdominoperineal Resection for Rectal Cancer, a Pilot Study
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE incisional negative-pressure wound therapy; abdominoperineal resection;
   rectal cancer
ID SURGICAL INCISIONS; MANAGEMENT-SYSTEM; RISK-FACTORS; COMPLICATIONS;
   SURGERY; CLOSURE; DEVICE; COHORT
AB Objective: Abdominoperineal resection (APR) is associated with high incidence of surgical wound infections. The use of incisional negative-pressure wound therapy (iNPWT) is known to reduce wound infections for several surgical indications. The aim of this pilot study was to investigate the potential of a new portable negative-pressure therapy device on perineal wound healing in patients undergoing APR.
   Approach: A new single-use incisional negative-pressure therapy device was applied in 10 patients. A negative pressure of -80mmHg was continued for 7 days postsurgery. Incidence of wound complications and time to wound healing were compared with a historical control group of 10 patients undergoing APR in 2014, treated with conventional wound care.
   Results: Patient characteristics were comparable in both groups. Mean 1.6 dressings were used per patient. A wound complication was diagnosed in seven patients versus six in the control group. Wound infections were diagnosed median 11.5 days after surgery, compared with 10.5 days in the control group. Duration of wound healing was shorter in the study group (median 8.5 weeks vs. 13 weeks).
   Innovation: This is the first study to report on the use of this iNPWT device for patients who underwent APR for rectal cancer.
   Conclusion: In this study, iNPWT did not reduce wound complications. Wound infections occurred slightly later and seemed to have a less severe clinical course. After treatment with iNPWT, the duration of wound healing was shorter.
C1 [van der Valk, Maxime J. M.; de Graaf, Eelco J. R.; Doornebosch, Pascal G.; Vermaas, Maarten] IJsselland Hosp, Dept Surg, Capelle aan den IJssel, Netherlands.
   [van der Valk, Maxime J. M.] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC
RP van der Valk, MJM (通讯作者)，IJsselland Hosp, Dept Surg, Prins Constantijnweg 2, NL-2906 ZC Capelle aan den IJssel, Netherlands.
EM mvandervalk@lumc.nl
RI van der valk, marc/AAQ-9026-2020
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   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
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   Hurd T, 2014, OSTOMY WOUND MANAG, V60, P30
   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
   Malmsjo Malin, 2014, Eplasty, V14, pe15
   Pellino G, 2014, SURG INNOV, V21, P204, DOI 10.1177/1553350613496906
   Selvaggi Francesco, 2014, Surg Technol Int, V24, P83
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   Wiatrek Rebecca L, 2008, Clin Colon Rectal Surg, V21, P76, DOI 10.1055/s-2008-1055325
NR 18
TC 18
Z9 19
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD DEC
PY 2017
VL 6
IS 12
BP 425
EP 429
DI 10.1089/wound.2017.0749
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FP8HQ
UT WOS:000417883800004
PM 29279806
DA 2026-07-24
ER
PT J
AU Ali, E
   Raghuvanshi, M
AF Ali, E.
   Raghuvanshi, M.
TI Treatment of open upper limb injuries with infection prevention and
   negative pressure wound therapy: a systematic review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE infection; negative pressure wound therapy; upper limb injuries; vacuum
   dressing
ID VACUUM-ASSISTED CLOSURE; LOCAL ANTIBIOTIC-THERAPY; VAC(R) THERAPY; BEAD
   POUCH; MANAGEMENT; FRACTURES; DELIVERY; COVERAGE; LESSONS
AB Objective: Open upper limb injuries requiring soft reconstruction can pose a dilemma for trauma surgeons when considering the treatment options. The British Orthopaedic Association and British Association of Plastic, Reconstructive and Aesthetic Surgeons Standard for Trauma (BOAST) have addressed the management of severe open lower limb fractures with the creation of the BOAST 4 guidelines. However, no such gold standard exists for the treatment of open injuries of the upper limb. Furthermore, treatment of these injuries is often more difficult and requires complicated strategies. Since the advent of negative pressure wound therapy (NPWT), there has been an improvement in wound care, though a focused review of its use in wound closure and infection prevention in the upper limb has not been published. We examine wound care management for open upper limb injuries with regard to the dressings applied, NPWT, wound closure and infection prevention.
   Method: A systematic search of Medline, Cochrane and Google Scholar was performed using the key words. The key word searches were performed by two independent reviewers and 8,792 papers were found. Manuscripts between 1990 and 2010 were included, with the addition of key manuscripts before this date. Each manuscript was assessed by the two authors independently for methodology and validity
   Results: Approximately 120 manuscripts fulfilled selection criteria examining the influence of NPWT on open upper and lower limb injuries, and those examining infection risk in the same injuries. Of these 120 manuscripts, 28 were suitable for inclusion in the review. The systematic review is presented, allied to the BOAST 4 principles, examining the use of NPWT and the tools available for infection prevention for wounds of the upper and lower limb. The use of NPWT in conjunction with antibiotic-bead therapy improved the way in which open fractures of both the upper and lower limb are treated.
   Conclusion: Production of guidelines is warranted for the treatment of upper limb injuries. The treatment options available for wound closure and infection prevention that are used in the treatment of open injuries of the lower limb could be adopted to open injuries of the upper limb.
C1 [Ali, E.] Univ Cambridge, Magdalene Coll, Clin Sch, Cambridge, England.
   [Raghuvanshi, M.] Broomfield Hosp, Chelmsford, England.
C3 University of Cambridge; Mid Essex Hospital Services NHS Trust;
   Broomfield Hospital
RP Ali, E (通讯作者)，Univ Cambridge, Magdalene Coll, Clin Sch, Cambridge, England.
EM ea389@cam.ac.uk
CR [Anonymous], JUST ILLUSION PLAST
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NR 29
TC 2
Z9 5
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2017
VL 26
IS 12
BP 712
EP 719
DI 10.12968/jowc.2017.26.12.712
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FQ2LG
UT WOS:000418187400003
PM 29244969
DA 2026-07-24
ER
PT J
AU Sutton, L
   Edwards, D
   McColl, M
AF Sutton, L.
   Edwards, D.
   McColl, M.
TI Outpatient negative pressure dressing therapy for pretibial lacerations
   in a patient with high anaesthetic risk: a case study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE adult congenital cardiac disease; negative pressure wound therapy;
   pretibial laceration; pulmonary atresia
ID CONGENITAL HEART-DISEASE; MANAGEMENT; ADULTS
AB Pretibial lacerations are a common cause of presentation to accident and emergency departments. The management of these wounds is contentious with a variation in practise between individual institutions. We present the case of a 49-year-old female with a background of pulmonary atresia and associated pulmonary hypertension, who underwent successful outpatient negative pressure wound therapy (NPWT) for three pretibial lacerations. We would propose that this therapy is an effective option for the management of these wounds in independently mobile patients who are at high-risk when under anaesthetic.
C1 [Sutton, L.] Univ Coll London Hosp NHS Trust, Head & Neck Ctr, London, England.
   [Sutton, L.] UCL, UCL Canc Inst, London, England.
   [Edwards, D.] Royal London Hosp, Barts Hlth NHS Trust, Plast Surg Dept, London, England.
C3 University College London Hospitals NHS Foundation Trust; University of
   London; University College London; University of London; University
   College London; Barts Health NHS Trust; Royal London Hospital
RP Sutton, L (通讯作者)，Univ Coll London Hosp NHS Trust, Head & Neck Ctr, London, England.; Sutton, L (通讯作者)，UCL, UCL Canc Inst, London, England.
EM liammsutton@gmail.com
CR [Anonymous], 1980, Pediatrics, V65, P375
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2017
VL 26
IS 12
BP 762
EP 764
DI 10.12968/jowc.2017.26.12.762
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FQ2LG
UT WOS:000418187400009
PM 29244964
DA 2026-07-24
ER
PT J
AU Pesonen, LO
   Halloran, BG
   Aziz, A
AF Pesonen, Luke O.
   Halloran, Brian G.
   Aziz, Abdulhameed
TI Prophylactic Groin Wound Vacuum-assisted Therapy in Vascular Surgery
   Patients at Enhanced Risk for Postoperative Wound Infection
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 27th Annual Winter Meeting of the
   Vascular-and-Endovascular-Surgery-Society (VESS)
CY FEB 02-05, 2017
CL Steamboat Springs, CO
SP Vasc & Endovascular Surg Soc
ID SURGICAL SITE INFECTION; PREVENTION; CLOSURE; MANAGEMENT
AB Background: Vascular groin wounds have higher than expected surgical site infection (SSI) rates and some patients are at enhanced risk. The Wiseman et al. paper suggests an objective scoring system that identifies patients at enhanced risk of postdischarge SSI. We hypothesize that prophylactic groin wound vacuum-assisted closure (VAC) therapy in enhanced risk patients will decrease SSI and readmission and the Wiseman model provides potential evidence that enhanced risk patients can be objectively identified.
   Methods: A single institution, retrospective analysis was conducted from January 2013 to September 2016 utilizing procedure codes to identify patients with wound VACs placed in the operating room. Two distinct groups were identified. The first was a wound complication patient group with 15 limbs (13 patients) with a groin wound VAC placed within 45 days postoperatively for groin wound complications. Eleven of these limbs had the VAC placed at readmission. The second group was a prophylactic patient group that included 8 limbs (7 patients) who received a VAC prophylactically placed in the enhanced risk wounds. These wounds were determined to be enhanced risk based on clinical criteria judged by the operating surgeon such as a large overhanging panniculus and/or one of several ongoing medical issues. We calculated a Wiseman score for all patients, determined total cost of the readmissions, and determined 30-day postsurgical SSI incidence for the prophylactic VAC group.
   Results: Per the Wiseman scores, 9 limbs with postoperative complications were high risk and 3 limbs were moderate/high risk. Eleven limbs had a VAC placed at readmission with an average readmission cost of $8876.77. For the prophylactic group, 8 limbs were high risk with no observed postdischarge SSI in the first 30 days from surgery. The Wiseman scores showed close correlation between the retrospective high and moderate/high risk groups versus the prophylactic VAC group (31.5 +/- 7.3 vs. 32 +/- 5.5, P = 0.87).
   Conclusions: The Wiseman scores showed objective validation in the prognosis of anticipating groin wound breakdown. Our initial results suggest that prophylactic groin wound VAC placement for enhanced risk vascular surgery patients may proactively decrease wound morbidity, decrease readmission secondary to groin wound complications, and provide some cost benefit.
C1 [Pesonen, Luke O.; Halloran, Brian G.; Aziz, Abdulhameed] St Joseph Mercy Hosp, Dept Surg, Ann Arbor, MI 48104 USA.
C3 Saint Joseph Mercy Health System (SJMHS)
RP Aziz, A (通讯作者)，IHA Vasc & Endovasc Specialists, 5201 Elliot Dr,Suite 101, Ypsilanti, MI 48197 USA.
EM Abdulhameed_aziz@ihacares.com
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
   CULVER DH, 1991, AM J MED, V91, pS152, DOI 10.1016/0002-9343(91)90361-Z
   Dosluoglu HH, 2010, J VASC SURG, V51, P1160, DOI 10.1016/j.jvs.2009.11.053
   Driver VR, 2014, J AM PODIAT MED ASSN, V104, P147, DOI 10.7547/0003-0538-104.2.147
   Kakagia D, 2014, INJURY, V45, P890, DOI 10.1016/j.injury.2012.02.002
   Kalish JA, 2014, J VASC SURG, V60, P1238, DOI 10.1016/j.jvs.2014.05.012
   Matatov T, 2013, J VASC SURG, V57, P791, DOI 10.1016/j.jvs.2012.09.037
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NR 10
TC 10
Z9 11
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD JAN
PY 2018
VL 46
BP 127
EP 133
DI 10.1016/j.avsg.2017.07.009
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA FQ3BZ
UT WOS:000418233100017
PM 28739464
DA 2026-07-24
ER
PT J
AU Ripamonti, B
   Raia-Barjat, T
   Chauleur, C
   Mathevet, P
AF Ripamonti, B.
   Raia-Barjat, T.
   Chauleur, C.
   Mathevet, P.
TI How do I prevent caesarean wound infections in obese patients in 2017?
SO GYNECOLOGIE OBSTETRIQUE FERTILITE & SENOLOGIE
LA French
DT Review
DE Obesity; Pregnancy; Wound infections; Cesarean section
ID SURGICAL SITE INFECTION; NEGATIVE-PRESSURE THERAPY; PERIOPERATIVE
   OXYGEN; MATERNAL OBESITY; RISK-FACTORS; DELIVERY; COMPLICATIONS;
   SECTION; WOMEN; PROPHYLAXIS
AB Obesity is an important risk factor of cesarean section and is associated with an increased risk of wound complications such as infections. This review focuses on the available strategies to limit complications in this population. Choice of antiseptic solution, appropriate dose and type of antibiotic prophylaxy, suture closure of subcutaneous fat, suture skin closure and closed incision negative pressure wound therapy may reduce the risk of wound infections associated with cesarean section in obese patients. Vaginal desinfection, plastic adhesive draps, high-concentration supplemental perioperative oxygen, use of a barrier retractor, wound drainage and type of skin incision are discussed in this review. Clinical trials of good quality are needed to improve our clinical practice. (c) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Ripamonti, B.; Raia-Barjat, T.; Chauleur, C.] Univ Hosp, Dept Gynecol & Obstet, St Etienne, France.
   [Raia-Barjat, T.; Chauleur, C.] Univ Jean Monnet, Res Unit EA3065, F-42023 St Etienne, France.
   [Mathevet, P.] Univ Lausanne, Univ Hosp, Gynecol Dept, Lausanne, Switzerland.
C3 CHU de St Etienne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV)
RP Ripamonti, B (通讯作者)，Univ Hosp, Dept Gynecol & Obstet, St Etienne, France.
EM bertripa@hotmail.com; tiphaine.barjat@chu-st-etienne.fr;
   celine.chauleur@chu-st-etienne.fr; patrice.mathevet@chuv.ch
RI ; Raia-Barjat, Tiphaine/AAJ-7310-2021
OI CHAULEUR, celine/0000-0003-4057-8133; Raia-Barjat,
   Tiphaine/0000-0002-4408-6075
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   Zaki MN, 2016, J PERINATOL, V36, P819, DOI 10.1038/jp.2016.89
NR 43
TC 0
Z9 0
U1 0
U2 4
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 2468-7197
EI 2468-7189
J9 GYNECOL OBST FERT SE
JI Gynecol. Obstet. Fertil. Senol.
PD NOV
PY 2017
VL 45
IS 11
BP 619
EP 622
DI 10.1016/j.gofs.2017.08.006
PG 4
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FQ5JY
UT WOS:000418396300008
PM 28964729
DA 2026-07-24
ER
PT J
AU Liu, H
   Zheng, X
   Chen, L
   Jian, C
   Hu, X
   Zhao, Y
   Li, ZH
   Yu, AX
AF Liu, Hong
   Zheng, Xun
   Chen, Liang
   Jian, Chao
   Hu, Xiang
   Zhao, Yong
   Li, Zonghuan
   Yu, Aixi
TI Negative pressure wound therapy promotes muscle-derived stem cell
   osteogenic differentiation through MAPK pathway
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE osteogenic differentiation; proliferation; muscle-derived stem cells;
   negative pressure wound therapy
ID ACTIVATED PROTEIN-KINASE; PHOSPHATIDYLINOSITOL 3-KINASE; OSTEOBLAST
   DIFFERENTIATION; SHEAR-STRESS; BONE; BMP-2; P38; MECHANISMS; FRACTURES;
   REPAIR
AB Negative pressure wound therapy (NPWT) has been revealed to be effective in the treatment of open fractures, although the underlying mechanism is not clear. This article aimed to investigate the effects of NPWT on muscle-derived stem cell (MDSC) osteoblastic differentiation and the related potential mechanism. The cell proliferation rate was substantially increased in NPWT-treated MDSCs in comparison with a static group for 3days. There was no observable effect on the apoptosis of MDSC treated with NPWT compared with the control group for 3days. The expression levels of HIF-1 alpha, BMP-2, COL-I, OST and OPN were increased on days 3, 7 and 14, but the expression level of Runx2 was increased on days 3 and 7 in the NPWT group. Pre-treatment, the specific inhibitors were added into the MDSCs treated with NPWT and the control group. ALP activity and mineralization were reduced by inhibiting the ERK1/2, p38 and JNK pathways. The expression levels of Runx2, COL-I, OST and OPN genes and proteins were also decreased using the specific MAPK pathway inhibitors on days 3, 7 and 14. There were no significant effects on the expression of BMP-2 except on day 3. However, the expressions of the HIF-1 alpha gene and protein slightly increased when the JNK pathway was inhibited. Therefore, NPWT promotes the proliferation and osteogenic differentiation of MDSCs through the MAPK pathway.
C1 [Liu, Hong; Zheng, Xun; Chen, Liang; Jian, Chao; Hu, Xiang; Zhao, Yong; Li, Zonghuan; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan, Hubei, Peoples R China.
C3 Wuhan University
RP Li, ZH; Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan, Hubei, Peoples R China.
EM lizonghuan@whu.edu.cn; yuaixi@whu.edu.cn
RI Liu, Hong/HLQ-6486-2023; Zheng, Xun/JEP-2802-2023
OI Liu, Hong/0000-0002-7534-1710; 
FU National Natural Science Foundation of China [81572163]; Wuhan Huanghe
   Elite Program; Hubei Provence's Outstanding Medical Academic Leader
   Program
FX The work was funded by the National Natural Science Foundation of China
   (Grant no. 81572163), the Wuhan Huanghe Elite Program and the Hubei
   Provence's Outstanding Medical Academic Leader Program. The author
   extends special thanks to Dr. Li Ping for his continuous support and for
   help with this article.
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NR 39
TC 11
Z9 15
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JAN
PY 2018
VL 22
IS 1
BP 511
EP 520
DI 10.1111/jcmm.13339
PG 10
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA FR0NQ
UT WOS:000418759200045
PM 28944996
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Acosta, S
   Seternes, A
   Venermo, M
   Vikatmaa, L
   Sörelius, K
   Wanhainen, A
   Svensson, M
   Djavani, K
   Björck, M
AF Acosta, Stefan
   Seternes, Arne
   Venermo, Maarit
   Vikatmaa, Leena
   Sorelius, Karl
   Wanhainen, Anders
   Svensson, Mats
   Djavani, Khatereh
   Bjorck, Martin
TI Open Abdomen Therapy with Vacuum and Mesh Mediated Fascial Traction
   After Aortic Repair: an International Multicentre Study
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE Open abdomen; Aortic repair; Open repair; Endovascular repair; Vacuum
   assisted closure; Mesh mediated fascial traction
ID ABDOMINAL COMPARTMENT SYNDROME; ASSISTED WOUND CLOSURE;
   NEGATIVE-PRESSURE; ENDOVASCULAR REPAIR; ANEURYSM REPAIR; MANAGEMENT;
   INFECTION; METAANALYSIS; LAPAROTOMY; CONSENSUS
AB Objectives: Open abdomen therapy may be necessary to prevent or treat abdominal compartment syndrome (ACS). The aim of the study was to analyse the primary delayed fascial closure (PDFC) rate and complications after open abdomen therapy with vacuum and mesh mediated fascial traction (VACM) after aortic repair and to compare outcomes between those treated with open abdomen after primary versus secondary operation.
   Methods: This was a retrospective cohort, multicentre study in Sweden, Finland, and Norway, including consecutive patients treated with open abdomen and VACM after aortic repair at six vascular centres in 2006-2015. The primary endpoint was PDFC rate.
   Results: Among 191 patients, 155 were men. The median age was 71 years (IQR 66-76). Ruptured abdominal aortic aneurysm (RAAA) occurred in 69.1%. Endovascular/hybrid and open repairs were performed in 49 and 142 patients, respectively. The indications for open abdomen were inability to close the abdomen (62%) at primary operation and ACS (80%) at secondary operation. Duration of open abdomen was 11 days (IQR 7-16) in 157 patients alive at open abdomen termination. The PDFC rate was 91.8%. Open abdomen initiated at primary (N = 103), compared with secondary operation (N = 88), was associated with less severe initial open abdomen status (p = .006), less intestinal ischaemia (p = .002), shorter duration of open abdomen (p = .007), and less renal replacement therapy (RRT, p < .001). In hospital mortality was 39.3%, and after entero-atmospheric fistula (N = 9) was 88.9%. Seven developed graft infection within 6 months, 1 year mortality was 28.6%. Intestinal ischaemia (OR 3.71, 95% CI 1.55-8.91), RRT (OR 3.62, 95% CI 1.72-7.65), and age (OR 1.12, 95% CI 1.06-1.12), were independent factors associated with in hospital mortality, but not open abdomen initiated at primary versus secondary operation.
   Conclusions: VACM was associated with a high PDFC rate after prolonged open abdomen therapy following aortic repair. Patient outcomes seemed better when open abdomen was initiated at primary, compared with secondary operation but a selection effect is possible. (C) 2017 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Acosta, Stefan] Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden.
   [Acosta, Stefan] Skane Univ Hosp, Dept Cardiothorac & Vasc Surg, Vasc Ctr, Ruth Lundskogsg 10, S-20502 Malmo, Sweden.
   [Seternes, Arne] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Vasc Surg, Trondheim, Norway.
   [Venermo, Maarit] Univ Helsinki, Dept Vasc Surg, Helsinki, Finland.
   [Venermo, Maarit; Vikatmaa, Leena] Helsinki Univ Hosp, Helsinki, Finland.
   [Vikatmaa, Leena] Univ Helsinki, Dept Anaesthet Intens Care & Pain Med, Helsinki, Finland.
   [Sorelius, Karl; Wanhainen, Anders; Bjorck, Martin] Uppsala Univ, Sect Vasc Surg, Dept Surg Sci, Uppsala, Sweden.
   [Svensson, Mats] Falun Cent Hosp, Dept Surg, Falun, Sweden.
   [Djavani, Khatereh] Gavle Cent Hosp, Dept Surg, Gavle, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Norwegian
   University of Science & Technology (NTNU); University of Helsinki;
   University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; Uppsala University; Falun Hospital
RP Acosta, S (通讯作者)，Skane Univ Hosp, Dept Cardiothorac & Vasc Surg, Vasc Ctr, Ruth Lundskogsg 10, S-20502 Malmo, Sweden.
EM Stefan.acosta@med.lu.se
RI Vikatmaa, Leena/AAY-1061-2020; Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798; Venermo, Maarit/0000-0001-8814-0988
CR Acosta S, 2007, EUR J VASC ENDOVASC, V33, P277, DOI 10.1016/j.ejvs.2006.09.017
   Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Acosta S, 2017, ANAESTH INTENSIVE TH, V49, P139, DOI 10.5603/AIT.a2017.0023
   Bahia SS, 2015, EUR J VASC ENDOVASC, V50, P320, DOI 10.1016/j.ejvs.2015.05.004
   Bee TK, 2008, J TRAUMA, V65, P337, DOI 10.1097/TA.0b013e31817fa451
   Björck M, 2016, SCAND J SURG, V105, P5, DOI 10.1177/1457496916631853
   Bjorsum-Meyer T, 2013, DAN MED J, V60
   Brandl A, 2014, HERNIA, V18, P105, DOI 10.1007/s10029-013-1064-0
   Carlson GL, 2013, ANN SURG, V257, P1154, DOI 10.1097/SLA.0b013e31828b8bc8
   Cheatham ML, 2013, WORLD J SURG, V37, P2018, DOI 10.1007/s00268-013-2080-z
   Cothren CC, 2006, AM J SURG, V192, P238, DOI 10.1016/j.amjsurg.2006.04.010
   Cristaudo A, 2017, AM SURGEON, V83, P191
   De Waele JJ, 2016, BJS-BRIT J SURG, V103, P709, DOI 10.1002/bjs.10097
   Ersryd S, 2016, EUR J VASC ENDOVASC, V52, P158, DOI 10.1016/j.ejvs.2016.03.011
   FitzGerald SF, 2005, J ANTIMICROB CHEMOTH, V56, P996, DOI 10.1093/jac/dki382
   Fortelny RH, 2014, SURG ENDOSC, V28, P735, DOI 10.1007/s00464-013-3251-6
   Kääriäinen M, 2017, SCAND J SURG, V106, P145, DOI 10.1177/1457496916665542
   Kafka-Ritsch R, 2012, WORLD J SURG, V36, P1765, DOI 10.1007/s00268-012-1586-0
   Karkos CD, 2014, J VASC SURG, V59, P829, DOI 10.1016/j.jvs.2013.11.085
   Kirkpatrick AW, 2015, ANN SURG, V262, P38, DOI 10.1097/SLA.0000000000001095
   Kirkpatrick AW, 2013, INTENS CARE MED, V39, P1190, DOI 10.1007/s00134-013-2906-z
   Mayer D, 2009, J VASC SURG, V50, P1, DOI 10.1016/j.jvs.2008.12.030
   Mohan PP, 2014, CARDIOVASC INTER RAD, V37, P337, DOI 10.1007/s00270-013-0665-4
   Mukhi AN, 2014, CAN J SURG, V57, P314, DOI 10.1503/cjs.026613
   Petersson U, 2016, HERNIA, V20, P755, DOI 10.1007/s10029-016-1516-4
   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   Powell JT, 2014, BMJ-BRIT MED J, V348, DOI 10.1136/bmj.f7661
   Rasilainen SK, 2012, BRIT J SURG, V99, P1725, DOI 10.1002/bjs.8914
   Rubenstein C, 2015, J VASC SURG, V61, P648, DOI 10.1016/j.jvs.2014.10.011
   Seternes A, 2017, WORLD J SURG, V41, P152, DOI 10.1007/s00268-016-3694-8
   Seternes A, 2010, EUR J VASC ENDOVASC, V40, P60, DOI 10.1016/j.ejvs.2010.02.018
   Smeds MR, 2016, J VASC SURG, V63, P332, DOI 10.1016/j.jvs.2015.08.113
   Sörelius K, 2013, EUR J VASC ENDOVASC, V45, P588, DOI 10.1016/j.ejvs.2013.01.041
   SZILAGYI DE, 1972, ANN SURG, V176, P321, DOI 10.1097/00000658-197209000-00008
   Tegler G, 2007, J VASC SURG, V45, P828, DOI 10.1016/j.jvs.2006.12.018
   Valentine R J, 2001, Semin Vasc Surg, V14, P292, DOI 10.1053/svas.2001.27874
   Willms A, 2015, LANGENBECK ARCH SURG, V400, P91, DOI 10.1007/s00423-014-1240-4
NR 37
TC 22
Z9 27
U1 0
U2 5
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD DEC
PY 2017
VL 54
IS 6
BP 697
EP 705
DI 10.1016/j.ejvs.2017.09.002
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA FR4RQ
UT WOS:000419053800005
PM 29033336
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Zamani, N
   Sharath, SE
   Vo, E
   Awad, SS
   Kougias, P
   Barshes, NR
AF Zamani, Nader
   Sharath, Sherene E.
   Vo, Elaine
   Awad, Samir S.
   Kougias, Panos
   Barshes, Neal R.
TI A Multi-Component Strategy to Decrease Wound Complications after Open
   Infra-Inguinal Re-Vascularization
SO SURGICAL INFECTIONS
LA English
DT Article
DE decontamination; staples; surgical site infection; vascular surgery
ID SURGICAL SITE INFECTIONS; LOWER-EXTREMITY BYPASS; PERIPHERAL
   ARTERY-DISEASE; RISK-FACTORS; REVASCULARIZATION PROCEDURES; SUBCUTICULAR
   SUTURES; ORTHOPEDIC-SURGERY; AMERICAN-COLLEGE; POVIDONE-IODINE; SKIN
   CLOSURE
AB Background: Wound complications remain a significant source of morbidity for patients undergoing open infra-inguinal re-vascularization. The purpose of this study was to determine the impact of several infection-control strategies on post-operative wound complications after open infra-inguinal re-vascularization. Methods: A retrospective cohort study was conducted among all patients who underwent an open infra-inguinal re-vascularization procedure before and after 2014. Since 2014, we have implemented strategies to reduce post-operative wound complications, including: (1) Decreasing the use of incisional skin staples, (2) increasing the use of negative pressure wound therapy (NPWT) dressings, and (3) implementing an outpatient elective decontamination protocol for methicillin-resistant Staphylococcus aureus. Pre-era is defined as the period between January 2012 and December 2013, before the implementation of infection control strategies; Post-era is between January 2015 and August 2016, after implementation. The primary outcome of interest is 30-day wound complications (infection or dehiscence). Multi-variable logistic regression analysis was used to identify significant predictors of wound-related complications between the two cohorts. Propensity score adjustment controlled for baseline patient characteristics, peri-operative variables, and surgeon experience. Results: A total of 338 open infra-inguinal procedures were performed: 175 in the pre-era and 163 in the post-era. Chlorhexidine skin preparation was used in the majority (321 [95%]) of cases. Comparing the periods, the post-era is characterized by a significant decrease in the use of groin staples (118 [67%] vs. 51 [31%], p<0.001), and an increased application of NPWT dressings (6 [4%] vs. 66 [43%], p<0.001). Thirty-five (37%) outpatient elective cases received the pre-operative decontamination protocol in the post-era. Compared with the pre-era, there was a decrease in the 30-day rate of wound complications (68 [39%] to 42 [26%], p=0.011), and infection-related re-admissions (31 [17.7%] to 21 [12.9%], p=0.220). When adjusting for patient characteristics, operative variables, and surgeon experience, post-era had significantly lower wound complications (odds ratio [OR] 0.33, p=0.002) and re-operations (OR 0.16, p=0.007). Among outpatient elective cases, the decontamination protocol was also independently associated with these two outcomes (wound complications: OR 0.05, p=0.006; re-operations: 0.06, p=0.002). The use of groin staples was an independent predictor of deep groin infections (OR 248, p<0.001) and re-operations (OR 8.16, p=0.032). Conclusions: Wound complications after open infra-inguinal re-vascularization have decreased significantly after the implementation of several infection-control strategies. Findings suggest that skin staples should be avoided in groin wounds, and anti-staphylococcal decontamination protocols decrease wound complications and prevent re-operations.
C1 [Zamani, Nader; Kougias, Panos; Barshes, Neal R.] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Michael E DeBakey Dept Surg, Div Vasc Surg & Endovasc Therapy, 2002 Holcombe Blvd OCL 112, Houston, TX 77030 USA.
   [Sharath, Sherene E.] Michael E DeBakey VA Med Ctr, Hlth Serv & Res Dev, Houston, TX USA.
   [Vo, Elaine; Awad, Samir S.] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Michael E DeBakey Dept Surg, Div Gen Surg, 2002 Holcombe Blvd OCL 112, Houston, TX 77030 USA.
C3 Baylor College of Medicine; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Michael E DeBakey VA Medical Center; Baylor
   College of Medicine; Baylor College Medical Hospital; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Michael E
   DeBakey VA Medical Center; Baylor College of Medicine
RP Barshes, NR (通讯作者)，Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Michael E DeBakey Dept Surg, Div Vasc Surg & Endovasc Therapy, 2002 Holcombe Blvd OCL 112, Houston, TX 77030 USA.
EM nbarshes@bcm.edu
RI Sharath, Sherene/JYP-3673-2024
CR American College of Radiology, 2013, ACR BI RADS, P85
   Bak J, 2017, ANN VASC SURG, V43, P197, DOI 10.1016/j.avsg.2016.11.011
   Ban KA, 2017, J AM COLL SURGEONS, V224, P59, DOI 10.1016/j.jamcollsurg.2016.10.029
   Bandyk DF, 2008, SEMIN VASC SURG, V21, P119, DOI 10.1053/j.semvascsurg.2008.05.008
   Bebko SP, 2015, JAMA SURG, V150, P390, DOI 10.1001/jamasurg.2014.3480
   Bennett KM, 2016, J VASC SURG, V63, P414, DOI 10.1016/j.jvs.2015.08.094
   Clay FSH, 2011, AM J OBSTET GYNECOL, V204, P378, DOI 10.1016/j.ajog.2010.11.018
   Damrauer SM, 2015, J VASC SURG, V62, P1192, DOI 10.1016/j.jvs.2015.06.213
   Darouiche RO, 2010, NEW ENGL J MED, V362, P18, DOI 10.1056/NEJMoa0810988
   de Lissovoy G, 2009, AM J INFECT CONTROL, V37, P387, DOI 10.1016/j.ajic.2008.12.010
   Duwayri Y, 2016, ANN VASC SURG, V36, P7, DOI 10.1016/j.avsg.2016.02.024
   Engemann JJ, 2003, CLIN INFECT DIS, V36, P592, DOI 10.1086/367653
   Graling PR, 2013, AORN J, V97, P547, DOI 10.1016/j.aorn.2013.02.009
   Greenblatt DY, 2011, J VASC SURG, V54, P433, DOI 10.1016/j.jvs.2011.01.034
   Han SM, 2015, VASC ENDOVASC SURG, V49, P69, DOI 10.1177/1538574415593498
   Kalish JA, 2014, J VASC SURG, V60, P1238, DOI 10.1016/j.jvs.2014.05.012
   Koetje JH, 2015, Surgery Research and Practice, V2015, P1, DOI [10.1155/2015/303560, 10.1155/2015/303560, DOI 10.1155/2015/303560]
   Krishnan R, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-009257
   Kuy S, 2014, ANN VASC SURG, V28, P53, DOI 10.1016/j.avsg.2013.08.002
   Mackeen AD, 2015, AM J OBSTET GYNECOL, V212, DOI 10.1016/j.ajog.2014.12.020
   Matatov T, 2013, J VASC SURG, V57, P791, DOI 10.1016/j.jvs.2012.09.037
   McGillicuddy EA, 2016, J VASC SURG, V64, P1780, DOI 10.1016/j.jvs.2016.05.068
   McPhee JT, 2013, J VASC SURG, V57, P955, DOI 10.1016/j.jvs.2012.09.077
   Phillips M, 2014, INFECT CONT HOSP EP, V35, P826, DOI 10.1086/676872
   Schweizer M, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2743
   Tsujinaka T, 2013, LANCET, V382, P1105, DOI 10.1016/S0140-6736(13)61780-8
   Vogel TR, 2013, J VASC SURG, V58, P90, DOI 10.1016/j.jvs.2012.12.031
   Wiseman JT, 2015, J VASC SURG, V62, P1023, DOI 10.1016/j.jvs.2015.04.453
   Yamaoka Y, 2015, LANGENBECK ARCH SURG, V400, P961, DOI 10.1007/s00423-015-1347-2
   Zhang JQ, 2014, J VASC SURG, V59, P1331, DOI 10.1016/j.jvs.2013.12.032
NR 30
TC 9
Z9 10
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD JAN
PY 2018
VL 19
IS 1
BP 87
EP 94
DI 10.1089/sur.2017.193
PG 8
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA FR9JV
UT WOS:000419390800014
PM 29303688
DA 2026-07-24
ER
PT J
AU Kamamoto, F
   Lima, ALM
   de Rezende, MR
   Mattar-Junior, R
   Leonhardt, MD
   Kojima, KE
   dos Santos, CC
AF Kamamoto, Fabio
   Munhoz Lima, Ana Lucia
   de Rezende, Marcelo Rosa
   Mattar-Junior, Rames
   Leonhardt, Marcos de Camargo
   Kojima, Kodi Edson
   dos Santos, Carla Chineze
TI A new low-cost negative-pressure wound therapy versus a
   commercially available therapy device widely used to treat complex
   traumatic injuries: a prospective, randomized, non-inferiority trial
SO CLINICS
LA English
DT Article
DE Negative-Pressure Wound Therapy; Wound Healing; Wounds and Injuries;
   Cost Savings
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EVALUATION
AB OBJECTIVES: Negative-pressure wound therapy has been widely adopted to reduce the complexity of treating a broad range of acute and chronic wounds. However, its cost is high. The objective of this study was to evaluate the following two different methods of negative-pressure wound therapy in terms of healing time: a low-cost method of negative-pressure wound therapy (a pressure stabilizer device connected to a hospital wall-vacuum system with a gauze-sealed dressing, USP) and the standard of care (vacuum-assisted closure, VAC).
   METHODS: This is a randomized, controlled, non-inferiority, unblinded trial. Patients admitted with complex injuries to a trauma center in a public referral hospital who were indicated for orthopedic surgery were randomized to a USP or VAC group. The primary outcome was the time required to achieve a "ready for surgery condition'', which was defined as a wound bed with healthy granulation tissue and without necrosis or purulent secretion. Wound bed area contraction, granulation tissue growth and the direct costs of the dressings were secondary outcomes.
   RESULTS: Variation in area and granulation tissue growth were essentially the same between the systems, and healing time was equal between the groups (p= 0.379). In both systems, serial debridement increased wound area (p= 0.934), and granulation tissue was also increased (p= 0.408). The mean treatment cost was US$ 15.15 in the USP group and US$ 872.59 in the VAC group.
   CONCLUSIONS: For treating complex traumatic injuries, USP was non-inferior to and less expensive than VAC.
C1 [Kamamoto, Fabio] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Sao Paulo, SP, Brazil.
   [Munhoz Lima, Ana Lucia] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Controle Infeccao Hosp, Sao Paulo, SP, Brazil.
   [de Rezende, Marcelo Rosa] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Microcirurgia, Sao Paulo, SP, Brazil.
   [Mattar-Junior, Rames; Leonhardt, Marcos de Camargo; Kojima, Kodi Edson] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Inst Ortopedia & Traumatol, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo
RP Kamamoto, F (通讯作者)，Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Sao Paulo, SP, Brazil.
EM fabio.kamamoto@gmail.com
RI de Rezende, Marcelo Rosa/AAZ-1293-2020; MATTAR, RAMES/K-3191-2016; LIMA,
   ANA/L-7898-2017; Kojima, Kodi/ACN-8737-2022
OI de Rezende, Marcelo Rosa/0000-0003-3441-8117; 
FU CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
   [400.804/2014-0]
FX The study was supported by financial assistance from CNPq (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico), grant
   400.804/2014-0.
CR [Anonymous], REV BRAS CIR PLAST
   Chaput B, 2015, PRS-GLOB OPEN, V3, DOI 10.1097/GOX.0000000000000347
   Dorafshar AH, 2012, ANN PLAS SURG, V69, P79, DOI 10.1097/SAP.0b013e318221286c
   Engeland CG, 2009, BRAIN BEHAV IMMUN, V23, P629, DOI 10.1016/j.bbi.2008.12.001
   Fenn CH, 2001, BRIT J PLAST SURG, V54, P348, DOI 10.1054/bjps.2000.3552
   Kim JJ, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001211
   Mansoor J, 2015, INT WOUND J, V12, P559, DOI 10.1111/iwj.12164
   Mirazimov B M, 1966, Ortop Travmatol Protez, V27, P19
   Moues C M, 2005, J Wound Care, V14, P224
   Runkel N, 2011, INJURY, V42, pS1, DOI 10.1016/S0020-1383(11)00041-6
   Wehrens KME, 2016, ADV SKIN WOUND CARE, V29, P254, DOI 10.1097/01.ASW.0000481179.88936.d4
   Wong LK, 2006, SOUTH MED J, V99, P628, DOI 10.1097/01.smj.0000217111.35160.09
   Yang Charlie C, 2006, J Surg Orthop Adv, V15, P19
   Zannis J, 2009, ANN PLAS SURG, V62, P407, DOI 10.1097/SAP.0b013e3181881b29
NR 14
TC 24
Z9 31
U1 0
U2 10
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PD DEC
PY 2017
VL 72
IS 12
BP 737
EP 742
DI 10.6061/clinics/2017(12)04
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FS4BB
UT WOS:000419730000004
PM 29319719
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Pines, G
   Bar, I
   Elami, A
   Sapojnikov, S
   Hikri, O
   Ton, D
   Mosenkis, B
   Melzer, E
AF Pines, Guy
   Bar, Ilan
   Elami, Amir
   Sapojnikov, Shimon
   Hikri, Ofir
   Ton, Dennis
   Mosenkis, Bruce
   Melzer, Ehud
TI Modified Endoscopic Vacuum Therapy for Nonhealing Esophageal Anastomotic
   Leak: Technique Description and Review of Literature
SO JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
LA English
DT Article
DE endoscopic treatment; esophageal fistula; anastomotic leakage;
   esophagectomy
ID THE-SCOPE-CLIP; UPPER GASTROINTESTINAL-TRACT; RECURRENT
   TRACHEOESOPHAGEAL FISTULA; FIBRIN GLUE INJECTION; ASSISTED CLOSURE;
   MULTICENTER EXPERIENCE; CLINICAL-OUTCOMES; TREATMENT OPTIONS; BEAR CLAW;
   MANAGEMENT
AB Background: Endoscopic vacuum-assisted closure (EVAC) therapy is increasingly being used as a new promising method for repairing upper gastrointestinal defects of different etiologies with high success rates. EVAC therapy consists of placing a sponge either within the lumen or within an abscess cavity connected with a nasogastric (NG) tube to a negative pressure system, thus decreasing bacterial contamination and edema and promoting granulation tissue proliferation, thereby gradually decreasing the cavity size until complete closure. Herein, we describe a modified technique for EVAC therapy in which the NG tube is passed into the esophagus through an existing intrapleural drain tract using a rendezvous technique. The small residual fistula was amendable to fibrin glue embolization. This allows easier sponge placement and exchange compared to traditional EVAC technique, and allows oral intake during treatment. We also review the literature regarding other endoscopic treatment options for esophageal anastomotic leaks and perforations.
   Methods: The PubMed database was searched using the terms "esophagus," "esophageal," "leak," "fistula," "endoluminal vacuum-assisted closure (VAC)," "endoscopic VAC," "stent," "sealant," "glue," and "over-the-scope clip (OTSC)" Reference lists of identified articles were searched for further articles, and the "similar articles" function was used on all included articles.
   Results: Complete closure of the nonhealing fistula was achieved after 8 days of EVAC treatment and fibrin glue embolization.
   Conclusions: Modified EVAC technique as described is feasible and safe. To the best of our knowledge, this is the first description of this technique. The technique allows easier sponge placement and exchange compared to traditional EVAC technique, and allows oral intake during treatment.
C1 [Pines, Guy; Bar, Ilan; Elami, Amir; Hikri, Ofir] Kaplan Med Ctr, Dept Thorac Surg, POB 1, IL-76100 Rehovot, Israel.
   [Sapojnikov, Shimon] Kaplan Med Ctr, Dept Surg, Rehovot, Israel.
   [Ton, Dennis] Kaplan Med Ctr, Dept Invas Radiol, Rehovot, Israel.
   [Mosenkis, Bruce; Melzer, Ehud] Kaplan Med Ctr, Dept Gastroenterol & Liver Dis, Rehovot, Israel.
   [Mosenkis, Bruce; Melzer, Ehud] Hebrew Univ Jerusalem, Sch Med, POB 1, IL-76100 Rehovot, Israel.
C3 Hebrew University of Jerusalem; Kaplan Medical Center; Hebrew University
   of Jerusalem; Kaplan Medical Center; Hebrew University of Jerusalem;
   Kaplan Medical Center; Hebrew University of Jerusalem; Kaplan Medical
   Center; Hebrew University of Jerusalem
RP Pines, G (通讯作者)，Kaplan Med Ctr, Dept Thorac Surg, POB 1, IL-76100 Rehovot, Israel.; Pines, G (通讯作者)，Hebrew Univ Jerusalem, Sch Med, POB 1, IL-76100 Rehovot, Israel.
EM guypi@clalit.org.il
RI Pines, Guy/A-4251-2017
OI Pines, Guy/0000-0003-2923-660X
CR Ahn JY, 2010, GUT LIVER, V4, P508, DOI 10.5009/gnl.2010.4.4.508
   Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
   Alanezi Khaled, 2004, Ann Thorac Cardiovasc Surg, V10, P71
   [Anonymous], 2013, Gastrointest Endosc
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NR 55
TC 31
Z9 40
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1092-6429
EI 1557-9034
J9 J LAPAROENDOSC ADV S
JI J. Laparoendosc. Adv. Surg. Tech.
PD JAN
PY 2018
VL 28
IS 1
BP 33
EP 40
DI 10.1089/lap.2017.0318
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FS5EY
UT WOS:000419818100006
PM 29019713
DA 2026-07-24
ER
PT J
AU Nickl, S
   Steindl, J
   Langthaler, D
   Nierlich-Hold, A
   Pona, I
   Hitzl, W
   Kocher, A
   Happak, W
   Radtke, C
   Tzou, CH
AF Nickl, Stefanie
   Steindl, Johannes
   Langthaler, Daniel
   Nierlich-Hold, Alina
   Pona, Igor
   Hitzl, Wolfgang
   Kocher, Alfred
   Happak, Wolfgang
   Radtke, Christine
   Tzou, Chieh-Han
TI First Experiences with Incisional Negative Pressure Wound Therapy in a
   High-Risk Poststernotomy Patient Population treated with Pectoralis
   Major Muscle Flap for Deep Sternal Wound Infection
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE deep sternal wound infection; pectoralis major muscle flap; surgical
   incision management system
ID VACUUM-ASSISTED CLOSURE; MYOCUTANEOUS ADVANCEMENT FLAPS;
   OPEN-HEART-SURGERY; MEDIAN STERNOTOMY; CARDIAC-SURGERY; SURGICAL
   INCISIONS; MANAGEMENT-SYSTEM; COMPLICATIONS; MEDIASTINITIS;
   RECONSTRUCTION
AB Background Radical debridement and wound closure with vascularized flaps has become a standard procedure in the treatment of deep sternal wound infections. Negative pressure incision management systems have been proven to diminish wound infections after sternotomy. In this study, the utility of Prevena Incision Management System (KCI Licensing Inc.) was evaluated in obese patients who received unilateral pectoralis major flap for the treatment of deep sternal wound infections.
   Methods The outcome and wound-related complication rates of 19 obese patients (mean body mass index, 33.7) treated for deep sternal wound infection with pectoralis major muscle flap in combination with Prevena between 2011 and 2016 were compared with 28 obese patients treated with conventional wound dressing only between 2000 and 2010.
   Results In patients additionally treated with Prevena, significantly fewer surgical revisions due to wound-related complications were necessary as compared with patients who received conventional wound dressing (5.3 vs. 32.1%, p =0.034). A significantly shorter ICU length of stay (median 0 vs. 3.5 days, p <0.001) and a trend toward shorter length of hospitalization (median 14 vs. 19.5 days after pectoralis major flap) could be observed.
   Conclusion The application of Prevena significantly reduced revision surgery rates in obese patients treated with unilateral pectoralis major flap for deep sternal wound infections.
C1 [Nickl, Stefanie; Langthaler, Daniel; Nierlich-Hold, Alina; Pona, Igor; Happak, Wolfgang; Radtke, Christine; Tzou, Chieh-Han] Med Univ Vienna, Div Plast & Reconstruct Surg, Dept Surg, Vienna, Austria.
   [Steindl, Johannes] Paracelsus Med Unvers, Dept Cardiac Surg, Salzburg, Austria.
   [Hitzl, Wolfgang] Paracelsus Med Univ Salzburg, Res Off, Biostat, Salzburg, Austria.
   [Kocher, Alfred] Med Univ Vienna, Div Cardiac Surg, Dept Surg, Vienna, Austria.
C3 Medical University of Vienna; Paracelsus Private Medical University;
   Medical University of Vienna
RP Tzou, CH (通讯作者)，Med Univ Vienna, Div Plast & Reconstruct Surg, Dept Surg, Vienna Gen Hosp, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM chieh-han.tzou@meduniwien.ac.at
RI Kocher, Alfred/OIS-7365-2025; Radtke, Christine/M-2927-2013; Hitzl,
   Wolfgang/A-1068-2013; Tzou, Chieh-Han John/A-4897-2017; Steindl,
   Johannes/OAJ-5398-2025
OI Kocher, Alfred/0000-0002-2818-2227; Radtke,
   Christine/0000-0001-6877-5038; Hitzl, Wolfgang/0000-0002-7696-1479;
   Nickl, Stefanie/0000-0002-3762-4840; Tzou, Chieh-Han
   John/0000-0002-3903-801X; 
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NR 53
TC 19
Z9 24
U1 1
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD JAN
PY 2018
VL 34
IS 1
BP 1
EP 7
DI 10.1055/s-0037-1605379
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FS8EN
UT WOS:000422643300001
PM 28992646
DA 2026-07-24
ER
PT J
AU Wertenauer, A
   Gräber, S
   Müller, CSL
AF Wertenauer, A.
   Graeber, S.
   Mueller, C. S. L.
TI Retrospective 8-year analysis of negative pressure wound therapy in
   dermatosurgery: a single-centre experience
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID INSTILLATION; RECOMMENDATIONS
AB Background Negative pressure wound therapy (NPWT) is an established treatment modality in dermatologic surgery, but proof of evidence for efficacy is inconclusive.
   Purpose To evaluate patient characteristics, treatment modalities and outcomes in a single dermatosurgery centre with NPWT applied over chronic and acute surgical wounds.
   Methods Of all surgical patients between 2008 and 2015, we selected those who were treated and hospitalized due to NPWT for treatment of acute and chronic wounds. The medical records of 188 patients were retrospectively evaluated and statistically calculated.
   Results Method of surgical defect closure depends significantly on localization of the surgical defect, cardiovascular comorbidity and age. Hence, outcome depends significantly on the surgical situation that indexes NPWT, the underlying diagnosis and the vacuum system used, but is not associated with distinct treatment modalities or gender of the patients. Hospitalization significantly depends on the vacuum system used, surgical situation that indexes NPWT and underlying diagnoses.
   Conclusion NPWT has a fixed role in distinct, well-defined clinical indications in dermatosurgery as the treatment of acute surgical wounds, fixation of skin grafts and treatment of skin substitutes, as well as an important treatment option for refractory, superinfected chronic wounds in dermatologic patients.
C1 [Wertenauer, A.; Mueller, C. S. L.] Saarland Univ, Med Ctr, Dept Dermatol, Homburg, Germany.
   [Graeber, S.] Saarland Univ, Med Ctr, Inst Biometry Epidemiol & Med Informat, Homburg, Saarland, Germany.
C3 Universitatsklinikum des Saarlandes; Universitatsklinikum des Saarlandes
RP Müller, CSL (通讯作者)，Saarland Univ, Med Ctr, Dept Dermatol, Homburg, Germany.
EM cornelia.mueller@uks.eu
OI Müller, Cornelia/0000-0002-7656-721X
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NR 15
TC 2
Z9 2
U1 1
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD JAN
PY 2018
VL 32
IS 1
BP 102
EP 107
DI 10.1111/jdv.14572
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FS9WZ
UT WOS:000422771300043
PM 28859231
DA 2026-07-24
ER
PT J
AU Polat, E
   Kutlubay, Z
   Sirekbasan, S
   Gökalp, H
   Akarirmak, Ü
AF Polat, Erdal
   Kutlubay, Zekayi
   Sirekbasan, Serhat
   Gokalp, Hilal
   Akarirmak, Ulku
TI Treatment of pressure ulcers with larvae of Lucilia sericata
SO TURKISH JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
LA English
DT Article
DE Decubitus ulcer; Lucilia sericata larvae; Maggot debridement therapy
ID MAGGOT THERAPY
AB Objectives: This study aims to investigate the use of the Lucilia sericata larvae in patients with decubitus ulcers resistant to hyperbaric oxygen treatment, vacuum-assisted closure, surgical debridement, and other conventional therapies.
   Patients and methods: A total of 36 patients (21 females, 15 males; mean age 63.7 years; range 16 to 90 years) who were admitted to our hospital for decubitus ulcers between February 2011 and July 2016 were included in our study. All patients had one or more lesions in the sacral region, trochanteric area, dorsal region, or on the heel of the foot. Nine patients had spinal cord injuries, six of them were injured during a car accident, and three of them had spinal cord injuries due to gunshot. One patient had concomitant lung cancer, one had heart failure, and two patients had a diagnosis of multiple sclerosis. Thirty three of 36 patients were admitted to the wound therapy unit within the department of emergency medicine, and three were admitted to the physical therapy and rehabilitation clinic. For each patient, Lucilia sericata maggots were applied on the lesions for 72 hours and, then, washed away. This procedure was repeated two times a week. Twenty nine patients (78.9%) had four to six sessions and seven patients (21.1%) had eight to 12 sessions.
   Results: Twenty nine lesions (78.9%) were Grade 2 and 3 and were completely healed after four to eight treatment sessions, while seven lesions (21.1%) were completely cured at the end of 10 to 14 sessions. There was complete clearance of necrotic debris at the end of two sessions within the first week for 15 lesions, whereas 10 lesions (27.8%) were cured after four sessions within two weeks, seven lesions (19.4%) within five sessions after three weeks, and four lesions (11.1%) were treated at the end of seven sessions for four weeks. All the necrotic crusts over the surface of the ulcers were cleaned and bad odor of the lesions disappeared.
   Conclusion: Lucilia sericata larvae debridement is a rapid and effective treatment option for the management of chronic decubitus ulcers which are resistant to conventional therapies and other treatment modalities such as hyperbaric oxygen, vacuum-assisted closure, and surgical debridement.
C1 [Polat, Erdal; Sirekbasan, Serhat] Istanbul Univ, Cerrahpasa Med Fac, Dept Med Microbiol, Istanbul, Turkey.
   [Kutlubay, Zekayi] Istanbul Univ, Cerrahpasa Med Fac, Dept Dermatol, Istanbul, Turkey.
   [Gokalp, Hilal; Akarirmak, Ulku] Koc Univ, Med Fac, Dept Dermatol, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   University; Istanbul University - Cerrahpasa; Koc University
RP Polat, E (通讯作者)，Istanbul Univ, Cerrahpasa Tip Fak, Tibbi Mikrobiyol Anabilim Dali, TR-34098 Istanbul, Turkey.
EM erdalp@istanbul.edu.tr
RI Kutlubay, Zekayi/A-6393-2018; Sirekbasan, Serhat/Q-1093-2018; POLAT,
   Erdal/D-7602-2019; AKARIRMAK, ZEYNEP ÜLKÜ/AAA-3923-2020
OI Sirekbasan, Serhat/0000-0001-7967-3539; POLAT,
   Erdal/0000-0002-3944-6443; AKARIRMAK, ZEYNEP ÜLKÜ/0000-0002-3288-3368
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NR 22
TC 9
Z9 11
U1 2
U2 12
PU BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
PI ATASEHIR
PA ORNEK MH DR SUPHI EZGI SK SARAY APT NO 11 D 6, ATASEHIR, ISTANBUL 34704,
   TURKEY
SN 2587-0823
J9 TURK J PH MED REHAB
JI Turk. J. Phys. Med. Rehabil.
PY 2017
VL 63
IS 4
BP 307
EP 312
DI 10.5606/tftrd.2017.851
PG 6
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA FT0CN
UT WOS:000422788100004
PM 31453472
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, DH
   Li, ZR
   Wang, GQ
   Li, TT
   Zhang, LH
   Tang, PF
AF Liu, Daohong
   Li, Zhirui
   Wang, Guoqi
   Li, Tongtong
   Zhang, Lihai
   Tang, Peifu
TI Virulence analysis of Staphylococcus aureus in a rabbit model of
   infected full-thickness wound under negative pressure wound therapy
SO ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR
   MICROBIOLOGY
LA English
DT Article
DE Bacterial virulence; Infection; Gene expression; Negative pressure wound
   therapy; Bioluminescent imaging
ID EXTRACELLULAR ADHERENCE PROTEIN; VACUUM-ASSISTED CLOSURE; SYSTEM;
   BINDING; IDENTIFICATION
AB The aim of this study was to evaluate the virulence of Staphylococcus aureus in a controlled animal study using the standard sterile gauze and negative pressure wound therapy (NPWT), including activation of agr, gene expression and production of virulence foctors and depth of bacterial invasion. The tissue specimens were harvested on days 0 (6 h after bacterial inoculation), 2, 4, 6, and 8 at the center of wound beds. Laser scanning confocal microscopy was performed to obtain bioluminescent images which were used to measure the depth of bacterial invasion. The agrA expression of S. aureus and the transcription and production of virulence factors including Eap, Spa and alpha-toxin were significantly different. The bacterial invasion depth was significantly less with effect of NPWT. The markedly different activation of quorum sensing systems that enable cell-to-cell communication and regulation of numerous colonization and virulence factors result in distinct gene expression and pathogenicity over time in different microenvironment. Thus, the agr system represents a fundamental regulatory paradigm that can encompass different adaptive strategies and accommodate horizontally acquired virulence determinants.
C1 [Liu, Daohong] PLA, Dept Orthoped, Hosp 309, Beijing 100091, Peoples R China.
   [Li, Zhirui; Wang, Guoqi; Zhang, Lihai; Tang, Peifu] Peoples Liberat Army, Dept Orthoped, Gen Hosp, Beijing 100853, Peoples R China.
   [Li, Zhirui] Chinese PLA Gen Hosp & Hainan Branch, Dept Orthoped, Sanya 572013, Peoples R China.
   [Li, Tongtong] Tianjin Hosp, Dept Orthoped, Tianjin 300211, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Tianjin University
RP Tang, PF (通讯作者)，Peoples Liberat Army, Dept Orthoped, Gen Hosp, Beijing 100853, Peoples R China.
EM domb@vip.sina.com; lzr860514@163.com; guoqi71@126.com; 707353114@qq.com;
   zhanglihai301@gmail.com; pftang301@163.com
RI Li, Zhirui/OJT-0490-2025
FU National Natural Science Foundation of China [81472112]
FX This study was supported by the National Natural Science Foundation of
   China (Grant No. 81472112).
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NR 33
TC 6
Z9 8
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0003-6072
EI 1572-9699
J9 ANTON LEEUW INT J G
JI Antonie Van Leeuwenhoek
PD FEB
PY 2018
VL 111
IS 2
BP 161
EP 170
DI 10.1007/s10482-017-0938-z
PG 10
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA FT1IQ
UT WOS:000422889100001
PM 28894985
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Kramer, A
   Dissemond, J
   Kim, S
   Willy, C
   Mayer, D
   Papke, R
   Tuchmann, F
   Assadian, O
AF Kramer, Axel
   Dissemond, Joachim
   Kim, Simon
   Willy, Christian
   Mayer, Dieter
   Papke, Roald
   Tuchmann, Felix
   Assadian, Ojan
TI Consensus on Wound Antisepsis: Update 2018
SO SKIN PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE Wound antisepsis; Wounds-at-Risk Score; Antiseptics; Drug; Medical
   device; Octenidine; Polihexanide; Hypochlorite; Iodophors; Taurolidine;
   Silver ions; Acetic acid; Negative pressure wound therapy with the
   instillation of antiseptics; Physical body warm atmospheric plasma;
   Silver sulfadiazine; Dyes; Mercury compounds; Hydrogen peroxide
ID RESISTANT STAPHYLOCOCCUS-AUREUS; TISSUE-TOLERABLE PLASMA; SUPER-OXIDIZED
   SOLUTION; RANDOMIZED CONTROLLED-TRIAL; SURGICAL SITE INFECTIONS; VENOUS
   LEG ULCERS; PSEUDOMONAS-AERUGINOSA BIOFILM; ATMOSPHERIC-PRESSURE PLASMA;
   CADEXOMER-IODINE OINTMENT; ACETIC-ACID TREATMENT
AB Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely consists of discussing properties of octenidine dihydrochloride (OCT), poli-hexanide, and iodophores. The evaluations of hypochlorite, taurolidine, and silver ions have been updated. For critically colonized and infected chronic wounds as well as for burns, polihexanide is classified as the active agent of choice. The combination 0.1% OCT/phenoxyethanol (PE) solution is suitable for acute, contaminated, and traumatic wounds, including MRSA-colonized wounds due to its deep action. For chronic wounds, preparations with 0.05% OCT are preferable. For bite, stab/puncture, and gunshot wounds, polyvinylpyrrolidone (PVP)-iodine is the first choice, while polihexanide and hypochlorite are superior to PVP-iodine for the treatment of contaminated acute and chronic wounds. For the decolonization of wounds colonized or infected with MDROs, the combination of OCT/PE is preferred. For peritoneal rinsing or rinsing of other cavities with a lack of drainage potential as well as the risk of central nervous system exposure, hypochlorite is the superior active agent. Silver-sulfadiazine is classified as dispensable, while dyes, organic mercury compounds, and hydrogen peroxide alone are classified as obsolete. As promising prospects, acetic acid, the combination of negative pressure wound therapy with the instillation of antiseptics (NPWTi), and cold atmospheric plasma are also subjects of this assessment. (C) 2017 S. Karger AG, Basel
C1 [Kramer, Axel; Papke, Roald] Univ Med Greifswald, Inst Hyg & Environm Med, Greifswald, Germany.
   [Kim, Simon] Univ Med Greifswald, Dept Trauma Reconstruct Surg & Rehabil Med, Greifswald, Germany.
   [Dissemond, Joachim] Univ Hosp Essen, Dept Dermatol Venerol & Allergol, Hufelandstr 55, DE-45147 Essen, Germany.
   [Willy, Christian] Bundeswehr Hosp, Dept Trauma Surg Orthoped Reconstruct Plast & Han, Berlin, Germany.
   [Mayer, Dieter] Kantonsspital Freiburg, Dept Surg, Freiburg, Germany.
   [Tuchmann, Felix] Med Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Vienna, Austria.
   [Assadian, Ojan] Med Univ Vienna, Vienna Gen Hosp, Dept Infect Control & Hosp Epidemiol, Vienna, Austria.
C3 Universitat Greifswald; Greifswald Medical School; Universitat
   Greifswald; Greifswald Medical School; University of Duisburg Essen;
   Medical University of Vienna; Medical University of Vienna
RP Dissemond, J (通讯作者)，Univ Hosp Essen, Dept Dermatol Venerol & Allergol, Hufelandstr 55, DE-45147 Essen, Germany.
EM joachim.dissemond@uk-essen.de
RI ; Assadian, Ojan/GVT-8804-2022; Dissemond, Joachim/AFG-0691-2022; Mayer,
   Dieter/E-7617-2011
OI Kim, Simon/0000-0002-7455-7421; Mayer, Dieter/0000-0001-5933-7749
FU Antiseptika chem.pharm. GmbH; B. Braun Melsungen AG; Bode/Paul Hartmann
   AG; Lohmann and Rauscher; Maquet GmbH; Schulke and Mayr GmbH; SERAG -
   WIESSNER GmbH and Co. KG; Oculus; Ethicon; 3M Healthcare; Acelity; B.
   Braun; Coloplast; Convatec; Draco; Engelhard; Flen Pharma; Lohmann
   Rauscher; Molnlycke; Serag-Wiesner; Urgo
FX Axel Kramer discloses that in the past he has received research support,
   lecture fees, and travel-cost reimbursements from the following
   companies: Antiseptika chem.pharm. GmbH, B. Braun Melsungen AG,
   Bode/Paul Hartmann AG, Lohmann and Rauscher, Maquet GmbH, Schulke and
   Mayr GmbH, SERAG - WIESSNER GmbH and Co. KG, Oculus, Ethicon, and 3M
   Healthcare. However, the present publication is not connected with
   financial interests.Joachim Dissemond discloses that in the past he has
   received research support, lecture fees, and travel-cost reimbursements
   from the following companies: Acelity, B. Braun, Coloplast, Convatec,
   Draco, Engelhard, Flen Pharma, Lohmann & Rauscher, Molnlycke,
   Serag-Wiesner, and Urgo.
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NR 314
TC 221
Z9 276
U1 1
U2 50
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-5527
EI 1660-5535
J9 SKIN PHARMACOL PHYS
JI Skin Pharmacol. Physiol.
PY 2018
VL 31
IS 1
BP 28
EP 58
DI 10.1159/000481545
PG 31
WC Dermatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Pharmacology & Pharmacy
GA FT4GK
UT WOS:000423111400004
PM 29262416
DA 2026-07-24
ER
PT J
AU Everett, E
   Mathioudakis, N
AF Everett, Estelle
   Mathioudakis, Nestoras
TI Update on management of diabetic foot ulcers
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Review
DE diabetes; diabetic foot ulcers; wound healing; diabetic foot management
ID ACELLULAR DERMAL MATRIX; PERIPHERAL ARTERIAL-DISEASE; AMNIOTIC MEMBRANE
   ALLOGRAFT; LOWER-EXTREMITY AMPUTATIONS; EPIDERMAL-GROWTH-FACTOR;
   PLATELET-RICH PLASMA; LEVEL LASER THERAPY; DOUBLE-BLIND;
   MULTIDISCIPLINARY TEAM; HYPERBARIC-OXYGEN
AB Diabetic foot ulcers (DFUs) are a serious complication of diabetes that results in significant morbidity and mortality. Mortality rates associated with the development of a DFU are estimated to be 5% in the first 12 months, and 5-year morality rates have been estimated at 42%. The standard practices in DFU management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off-loading, vascular assessment, and infection and glycemic control. These practices are best coordinated by a multidisciplinary diabetic foot wound clinic. Even with this comprehensive approach, there is still room for improvement in DFU outcomes. Several adjuvant therapies have been studied to reduce DFU healing times and amputation rates. We reviewed the rationale and guidelines for current standard of care practices and reviewed the evidence for the efficacy of adjuvant agents. The adjuvant therapies reviewed include the following categories: nonsurgical debridement agents, dressings and topical agents, oxygen therapies, negative pressure wound therapy, acellular bioproducts, human growth factors, energy-based therapies, and systemic therapies. Many of these agents have been found to be beneficial in improving wound healing rates, although a large proportion of the data are small, randomized controlled trials with high risks of bias.
C1 [Everett, Estelle; Mathioudakis, Nestoras] Johns Hopkins Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, 1830 East Monument St,Suite 333, Baltimore, MD 21205 USA.
C3 Johns Hopkins University
RP Mathioudakis, N (通讯作者)，Johns Hopkins Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, 1830 East Monument St,Suite 333, Baltimore, MD 21205 USA.
EM nmathio1@jhmi.edu
RI Mathioudakis, Nestoras/AAP-4595-2020; Everett, Estelle/JXN-1795-2024
OI Mathioudakis, Nestoras/0000-0002-0210-655X; Everett,
   Estelle/0000-0002-7468-296X
FU NIDDK NIH HHS [R01 DK115648, T32 DK062707] Funding Source: Medline;
   National Institute of Diabetes and Digestive and Kidney Diseases
   [T32DK062707] Funding Source: NIH RePORTER
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NR 102
TC 671
Z9 819
U1 19
U2 376
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD JAN
PY 2018
VL 1411
IS 1
SI SI
BP 153
EP 165
DI 10.1111/nyas.13569
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FU0PE
UT WOS:000423552000011
PM 29377202
OA Green Submitted
HC Y
HP N
DA 2026-07-24
ER
PT J
AU Novelli, G
   Daleffe, F
   Birra, G
   Canzi, G
   Mazzoleni, F
   Boni, P
   Maino, C
   Giussani, C
   Sozzi, D
   Bozzetti, A
AF Novelli, Giorgio
   Daleffe, Francesco
   Birra, Gisella
   Canzi, Gabriele
   Mazzoleni, Fabio
   Boni, Pietro
   Maino, Clara
   Giussani, Carlo
   Sozzi, Davide
   Bozzetti, Alberto
TI Negative pressure wound therapy in complex cranio-maxillofacial and
   cervical wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; VAC Therapy cervical wounds;
   Cranio-maxillofacial wounds; Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; NECK-SURGERY; SUCTION; HEAD
AB The care and the management of the healing of difficult wounds at the level of the skull-facial face many problems related to patient compliance and the need to perform multiple dressings, with long periods of healing and, occasionally, a very long hospitalisation period. The introduction and evolution of negative pressure wound therapy (NPWT) in the treatment of difficult wounds has resulted in better healing, with a drastic reduction in terms of time and biological costs to the patient and cost to the health care system. The main aim of this study is to describe and discuss, using out our experience, the usefulness of NPWT in the cranial-facial-cervical region. We studied 16 patients with complex wounds of the cranial-facial-cervical region treated with NPWT. We divided clinical cases in four groups: cervicofacial infectious disease, healing complications in oncological-reconstructive surgery, healing complications of injury with exposure of bone and/or internal fixations and healing complications in traumatic injury with loss of substance. We evaluated complete or incomplete wound healing; application time, related also to hospitalisation time; days of intensive care unit (ICU) stay; management of the upper airways; timing of medication renewal; and patient comfort and compliance (on a scale of 1-5). Depression values were always between -75 and -125 mmHg in a continuous aspiration pattern. For every patient, we used the ActiVAC Therapy Unit, derived from the vacuum-assisted closure system (Kinetic Concepts Inc., San Antonio, TX). Medication renewals were performed every 48-72 hours. The NPWT application time ranged from 4 to 22 days (mean of 1157 day). Therapy was effective to gain a complete restitutio ad integrum in every patient included in the group of cervicofacial infectious disease. Therapy has, however, been well tolerated in our series; this is probably due to the decreased number of applications, the ease of use and the comfort of the system relative to traditional dressing. Results were satisfactory for most of cases treated; faster and more effective wound healing was achieved. The lower number of NPWT applications, relating to standard dressings, led to an increase in patient comfort and compliance and a decrease in the use of medical, and in some cases economic, resources according to international literature.
C1 [Novelli, Giorgio; Daleffe, Francesco; Birra, Gisella; Mazzoleni, Fabio; Boni, Pietro; Sozzi, Davide; Bozzetti, Alberto] Univ Milano Bicocca, Asst San Gerardo Hosp, Dept Maxillofacial Surg, Monza, Italy.
   [Canzi, Gabriele] Osped Niguarda Ca Granda, Dept Maxillofacial Surg, Milan, Italy.
   [Maino, Clara] Asst San Gerardo Hosp, Dept Profess Hlth, Outpatient Clin Adv Wound Care, Monza, Italy.
   [Giussani, Carlo] Univ Milano Bicocca, Asst San Gerardo Hosp, Dept Neurosurg, Monza, Italy.
C3 University of Milano-Bicocca; IRCCS Ca Granda Ospedale Maggiore
   Policlinico; Ospedale Niguarda Ca' Granda; University of Milano-Bicocca
RP Novelli, G (通讯作者)，San Gerardo Hosp, Dept Maxillofacial Surg, Via Pergolesi 33, Monza, MI, Italy.
EM g.novelli@asst-monza.it
RI Novelli, Giorgio/ABB-6690-2020; GIUSSANI, CARLO GIORGIO/AAC-2941-2022;
   Canzi, Gabriele/GYU-8144-2022; SOZZI, DAVIDE/AAM-3681-2021;
   /AAA-4070-2021
OI Novelli, Giorgio/0000-0003-2357-6726; GIUSSANI, CARLO
   GIORGIO/0000-0002-9033-2927; Canzi, Gabriele/0000-0002-2513-369X; SOZZI,
   DAVIDE/0000-0002-6281-5307; 
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NR 35
TC 17
Z9 20
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2018
VL 15
IS 1
BP 16
EP 23
DI 10.1111/iwj.12802
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FU4JG
UT WOS:000423818800003
PM 29171161
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Torbrand, C
   Anesäter, E
   Borgquist, O
   Malmsjö, M
AF Torbrand, Christian
   Anesater, Erik
   Borgquist, Ola
   Malmsjo, Malin
TI Mechanical effects of negative pressure wound therapy on abdominal
   wounds - effects of different pressures and wound fillers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal wounds; Experimental surgery; Pain; Vacuum-assisted closure;
   Wound healing
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; OF-THE-LITERATURE;
   GAUZE; CONTRACTION; NPWT; FOAM; FOUNDATION; EXPERIENCE
AB The mechanical deformation of the wound edge resulting from negative pressure wound therapy (NPWT) at the standard setting of around -120 mmHg has positive effects in promoting wound healing. However, it may cause pain to the patient during treatment. It is therefore important to study the mechanical effects of the wound edges using lower pressure and different wound fillers. Abdominal wounds were created on eight pigs. The wounds were sealed for NPWT using foam or gauze. Negative pressures between -20 and -160 mmHg were applied, and the decrease in wound diameter and the force with which the edges of the wound were drawn together (wound edge force) were measured. Increasing levels of negative pressure resulted in a gradual decrease in wound diameter and increase in wound edge force and reached a maximum at -120 mmHg, which is the pressure commonly used in clinical practice. Both the decrease in wound diameter and the increase in wound edge force was greater with foam than with gauze. A pressure of -80 mmHg has only 15% less effect than -120 mmHg, while a lower pressure (-40 mmHg) diminished the effects on diameter and force markedly. The NPWT-induced decrease in wound diameter and increase in wound edge force are greater at higher levels of negative pressure and when using foam than when using gauze as a wound filler. It may be possible to tailor the type of wound filler and level of negative pressure to obtain the best balance between wound healing and patient comfort.
C1 [Torbrand, Christian] Lund Univ, Clin Sci, Dept Urol, Lund, Sweden.
   [Torbrand, Christian; Borgquist, Ola; Malmsjo, Malin] Skane Univ Hosp, Malmo, Sweden.
   [Anesater, Erik] Danderyd Hosp, Dept Cardiol, Stockholm, Sweden.
   [Borgquist, Ola] Lund Univ, Clin Sci, Dept Anaesthesia & Intens Care, Lund, Sweden.
   [Malmsjo, Malin] Lund Univ, Clin Sci, Dept Ophthalmol, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Danderyds
   Hospital; Lund University; Lund University
RP Torbrand, C (通讯作者)，Skane Univ Hosp, Dept Urol, SE-20502 Malmo, Sweden.
EM christian.torbrand@med.lu.se
RI Torbrand, Christian/HIZ-8092-2022; Borgquist, Ola/AAO-6451-2020
OI Torbrand, Christian/0000-0001-6442-7554; Maljö,
   Malin/0000-0001-9849-9599; 
FU Swedish Government Grant for Clinical Research (ALF); Swedish Research
   Council (VR); Skane University Hospital (SUS) Research Grants
FX The study was supported by the Swedish Government Grant for Clinical
   Research (ALF), the Swedish Research Council (VR) and the Skane
   University Hospital (SUS) Research Grants. The authors declared no
   conflicts of interest.
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NR 30
TC 10
Z9 15
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2018
VL 15
IS 1
BP 24
EP 28
DI 10.1111/iwj.12810
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FU4JG
UT WOS:000423818800004
PM 29171143
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Pleger, SP
   Nink, N
   Elzien, M
   Kunold, A
   Koshty, A
   Böning, A
AF Pleger, Sebastian P.
   Nink, Nadine
   Elzien, Meshal
   Kunold, Alexander
   Koshty, Ahmed
   Boening, Andreas
TI Reduction of groin wound complications in vascular surgery patients
   using closed incision negative pressure therapy (ciNPT): a prospective,
   randomised, single-institution study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE closed incision negative pressure therapy; surgical site infections;
   vascular surgery; wound healing
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISION; HIGH-RISK; ARTERIAL
   RECONSTRUCTION; MANAGEMENT-SYSTEM; SKIN-GRAFTS; INFECTION; PREVENTION;
   PREVENA(TM); DRESSINGS
AB Groin wound infections in patients undergoing vascular procedures often cause a lengthy process of wound healing. Several clinical studies and case reports show a reduction of surgical site infections (SSIs) in various wound types after using closed incision negative pressure therapy (ciNPT). The aim of this prospective, randomised, single-institution study was to investigate the effectiveness of ciNPT (PREVENA Therapy) compared to conventional therapy on groin incisions after vascular surgery. From 1 February to 30 October 2015, 100 patients with 129 groin incisions were analysed. Patients were randomised and treated with either ciNPT (n = 58 groins) or the control dressing (n = 71 groins). ciNPT was applied intraoperatively and removed on days 5-7 postoperatively. The control group received a conventional adhesive plaster. Wound evaluation based on the Szilagyi classification took place postoperatively on days 5-7 and 30. Compared to the control group, the ciNPT group showed a significant reduction in wound complications (P < 00005) after both wound evaluation periods and in revision surgeries (P = 0022) until 30 days postoperatively. Subgroup analysis revealed that ciNPT had a significant effect on almost all examined risk factors for wound healing. ciNPT significantly reduced the incidence of incision complications and revision procedures after vascular surgery.
C1 [Pleger, Sebastian P.; Nink, Nadine; Elzien, Meshal; Kunold, Alexander; Koshty, Ahmed] Jung Stilling Hosp, Dept Vasc Surg, Wichernstr 40, D-57074 Siegen, Germany.
   [Pleger, Sebastian P.; Boening, Andreas] Justus Liebig Univ, Univ Hosp, Dept Cardiovasc Surg, Giessen, Germany.
C3 Justus Liebig University Giessen
RP Pleger, SP (通讯作者)，Jung Stilling Hosp, Dept Vasc Surg, Wichernstr 40, D-57074 Siegen, Germany.
EM sebastian.pleger@diakonie-sw.de
RI Boening, Andreas/LMN-9531-2024
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NR 42
TC 84
Z9 90
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2018
VL 15
IS 1
BP 75
EP 83
DI 10.1111/iwj.12836
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FU4JG
UT WOS:000423818800011
PM 29068153
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Nevitt, BN
   Adkesson, MJ
   Jankowski, G
   West, P
   Langan, JN
AF Nevitt, Benjamin N.
   Adkesson, Michael J.
   Jankowski, Gwen
   West, Paula
   Langan, Jennifer N.
TI Lumbar hemilaminectomy for treatment of diskospondylitis in an aardvark
   (Orycteropus afer)
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID VACUUM-ASSISTED-CLOSURE; SPINAL DECOMPRESSION; OSTEOMYELITIS
AB CASE DESCRIPTION
   A 17-year-old sexually intact male aardvark (Orycteropus afer) was evaluated because of hind limb proprioception deficits and ataxia.
   CLINICAL FINDINGS
   Results of examination and CT suggested a diagnosis of intervertebral disk disease and diskospondylitis at the L2-3 intervertebral space. Magnetic resonance imaging of the vertebral column also indicated intervertebral disk rupture with spinal cord compression and inflammation of the adjacent epaxial musculature
   TREATMENT AND OUTCOME
   Hemilaminectomy was performed according to the technique described for dogs. Anatomic variations encountered intraoperatively limited the ability to completely remove the affected disk material; however, adequate decompression of the spinal cord was achieved. Microbial culture and susceptibility testing of surgical biopsy specimens yielded a multidrug-resistant Enterococcus faecalis that was treated with a 10-week course of linezolid. Intensive postoperative care required constant rate infusions for adequate sedation, analgesia, and antimicrobial treatment. Dehiscence of the surgical site occurred 3 weeks after surgery and was treated with negative pressure wound therapy. Physical rehabilitation initiated 5 days after surgery progressed from passive range of motion to the use of an underwater treadmill. Despite initial improvement, acute deterioration occurred 5.5 months after surgery. Repeated CT revealed progression of diskospondylitis, which prompted euthanasia.
   CLINICAL RELEVANCE
   Postoperative hind limb paresis and paralysis in this species presented considerable challenges for care and rehabilitation. Patient demeanor, size, and anatomy required development of custom mechanical devices. Despite the inability to eliminate the multidrug-resistant bacterial osteomyelitis that resulted in the death of this aardvark, information gained may benefit treatment of subsequent patients.
C1 [Nevitt, Benjamin N.; Adkesson, Michael J.; Langan, Jennifer N.] Brookfield Zoo, Chicago Zool Soc, 3300 Golf Rd, Brookfield, IL 60513 USA.
   [Jankowski, Gwen] Denver Zoo, 2300 Steele St, Denver, CO 80205 USA.
   [West, Paula] Vet Specialty Ctr, 1515 Busch Pkwy, Buffalo Grove, IL 60089 USA.
   [Langan, Jennifer N.] Univ Illinois, Dept Vet Clin Med, Coll Vet Med, Urbana, IL 61802 USA.
   [Nevitt, Benjamin N.] San Diego Zoo, 2920 Zoo Dr, San Diego, CA 92101 USA.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   Zoological Society of San Diego
RP Nevitt, BN (通讯作者)，Brookfield Zoo, Chicago Zool Soc, 3300 Golf Rd, Brookfield, IL 60513 USA.; Nevitt, BN (通讯作者)，San Diego Zoo, 2920 Zoo Dr, San Diego, CA 92101 USA.
EM bnevitt@sandiegozoo.org
OI Adkesson, Michael/0000-0002-8766-5296
CR Adkesson MJ, 2007, JAVMA-J AM VET MED A, V231, P1249, DOI 10.2460/javma.231.8.1249
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NR 21
TC 1
Z9 1
U1 0
U2 7
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
EI 1943-569X
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD FEB 15
PY 2018
VL 252
IS 4
BP 464
EP 472
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FU8JO
UT WOS:000424099400022
PM 29393738
DA 2026-07-24
ER
PT J
AU Tan, L
   Hou, ZY
   Gao, YZ
AF Tan, Lei
   Hou, Zhongyu
   Gao, Yanzhi
TI Efficacy of combined treatment with vacuum sealing drainage and
   recombinant human epidermal growth factor for refractory wounds in the
   extremities and its effect on serum levels of IL-6, TNF-α and IL-2
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE vacuum sealing drainage; recombinant human epidermal growth factor; hand
   and foot surgery; refractory wound; inflammatory factor
ID DIABETIC FOOT ULCERS; THERAPY; REGENERATION; ENHANCE; QUALITY; RHEGF
AB The objective of this study was to investigate the efficacy of combined treatment with vacuum sealing drainage (VSD) and recombinant human epidermal growth factor (rhEGF) for refractory wounds in the extremities, and its effect on serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and IL-2. Ninety-eight patients with refractory wounds in the extremities were recruited and randomly divided into the combined treatment group (underwent VSD and rhEGF treatment) and control group (underwent VSD only) with 49 cases each. Formation of granulation tissue on the wound surface was assessed and scored. The wound healing rate was calculated after 1 week of treatment, and the time of complete healing was recorded. Serum levels of IL-6, IL-2, and TNF-alpha were measured using enzyme-linked immunosorbent assay. After 1 week of treatment, granulation tissue formation on wound surfaces was significantly improved (p<0.05) compared with that before treatment in both groups. Moreover, granulation tissue formation on wound surfaces was superior in the combined treatment group than in the control group (p<0.05). The wound healing rate was 63.50 +/- 4.75% in the combined treatment group and 31.79 +/- 3.52% in the control group, and the difference was statistically significant (p<0.05). The time of complete healing was 15.11 +/- 2.24 days in the combined treatment group and 19.63 +/- 2.76 days in the control group, and the difference was statistically significant (p<0.05). The serum levels of IL-6, IL-2, and TNF-alpha, in the two groups were significantly lower than those before treatment (p<0.05). Moreover, the levels in the combined treatment group were significantly lower than those in the control group (p<0.05). In conclusion, combined treatment with VSD and rhEGF reduced inflammation and shortened the time of complete healing of refractory wounds in the extremities. Measurement of the levels of related inflammatory factors provided a reference for the prognosis of refractory wounds.
C1 [Tan, Lei] Zhangqiu Hosp Chinese Med, Traumatol Ward 1, Zhangqiu 250200, Shandong, Peoples R China.
   [Hou, Zhongyu] Laiwu Iron & Steel Grp Co Ltd Hosp, Traumatol Ward 2, Laiwu 271126, Shandong, Peoples R China.
   [Gao, Yanzhi] Cent Hosp Shengli Oilfield, Dept Emergency, 31 Jinan Rd, Dongying 257034, Shandong, Peoples R China.
RP Gao, YZ (通讯作者)，Cent Hosp Shengli Oilfield, Dept Emergency, 31 Jinan Rd, Dongying 257034, Shandong, Peoples R China.
EM gyp7pv@163.com
RI hou, zhong/KZT-9649-2024
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
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   Cheng HT, 2014, INTERACT CARDIOV TH, V19, P1048, DOI 10.1093/icvts/ivu289
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NR 22
TC 12
Z9 16
U1 0
U2 9
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JAN
PY 2018
VL 15
IS 1
BP 288
EP 294
DI 10.3892/emt.2017.5360
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FV0WL
UT WOS:000424281600038
PM 29250151
DA 2026-07-24
ER
PT J
AU Valli, PV
   Mertens, J
   Kröger, A
   Gubler, C
   Gutschow, C
   Schneider, PM
   Bauerfeind, P
AF Valli, Piero V.
   Mertens, JoachimC.
   Kroger, Arne
   Gubler, Christoph
   Gutschow, Christian
   Schneider, Paul M.
   Bauerfeind, Peter
TI Stent-over-sponge (SOS): a novel technique complementing endosponge
   therapy for foregut leaks and perforations
SO ENDOSCOPY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKS
AB Background and study aims Endoluminal vacuum therapy (EVT) has evolved as a promising option for endoscopic treatment of foregut wall injuries in addition to the classic closure techniques using clips or stents. To improve vacuum force and maintain esophageal passage, we combined endosponge treatment with a partially covered self-expandable metal stent (stent-over-sponge; SOS).
   Patients and methods Twelve patients with infected upper gastrointestinal wall defects were treated with the SOS technique.
   Results Indications for SOS were anastomotic leakage after surgery (n = 11) and chronic foregut fistula (n = 1). SOS treatment was used as a first-line treatment in seven patients with a success rate of 71.4% (5/7) and as a second-line treatment after failed previous EVT treatment in five patients (success rate 80 %; 4/5). Overall, SOS treatment was successful in 75% of patients (9/12). No severe adverse events occurred.
   Conclusion SOS is an effective method to treat severely infected foregut wall defects in patients where EVT has failed, and also as a first-line treatment. Comparative prospective studies are needed to confirm our preliminary results.
C1 [Valli, Piero V.; Mertens, JoachimC.; Kroger, Arne; Gubler, Christoph; Bauerfeind, Peter] Univ Hosp Zurich, Div Gastroenterol & Hepatol, Zurich, Switzerland.
   [Gutschow, Christian; Schneider, Paul M.] Univ Hosp Zurich, Dept Visceral & Transplant Surg, Zurich, Switzerland.
   [Schneider, Paul M.] Hirslanden Med Ctr, Ctr Visceral Thorac & Specialized Tumor Surg, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP Bauerfeind, P (通讯作者)，Univ Spital Zurich, Klin Gastroenterol & Hepatol, Ramistr 100, CH-8091 Zurich, Switzerland.
EM peter.bauerfeind@gmx.ch
RI ; Bauerfeind, Peter/AAV-2069-2020
OI Mertens, Joachim C/0000-0003-2007-0308; 
CR Dumonceau JM, 2015, ENDOSCOPY, V47, P1175, DOI 10.1055/s-0034-1393414
   Gubler C, 2013, DIS ESOPHAGUS, V26, P598, DOI 10.1111/dote.12005
   Gubler C, 2014, SCAND J GASTROENTERO, V49, P23, DOI 10.3109/00365521.2013.850735
   Kuehn F, 2017, SURG ENDOSC, V31, P3449, DOI 10.1007/s00464-016-5404-x
   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
   Patrick PG, 1997, GASTROINTEST ENDOSC, V45, P72, DOI 10.1016/S0016-5107(97)70305-5
   Schneider PM, EUROPEAN MANUAL MED, V201, P263
   Thompson JT, 2007, CLIN PLAST SURG, V34, P673, DOI 10.1016/j.cps.2007.07.005
   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
NR 9
TC 44
Z9 49
U1 0
U2 6
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0013-726X
EI 1438-8812
J9 ENDOSCOPY
JI Endoscopy
PD FEB
PY 2018
VL 50
IS 2
BP 148
EP 153
DI 10.1055/s-0043-120442
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA FV1UF
UT WOS:000424349600018
PM 29186638
DA 2026-07-24
ER
PT J
AU DeFazio, MV
   Economides, JM
   Anghel, EL
   Mathis, RK
   Barbour, JR
   Attinger, CE
AF DeFazio, Michael V.
   Economides, James M.
   Anghel, Ersilia L.
   Mathis, Ryan K.
   Barbour, John R.
   Attinger, Christopher E.
TI Traction-assisted Internal Negative Pressure Wound Therapy With Bridging
   Retention Sutures to Facilitate Staged Closure of High-risk Wounds Under
   Tension
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE delayed primary closure; dermatotraction; negative pressure wound
   therapy; retention sutures; staged reconstruction
ID EXTERNAL TISSUE EXPANDER; OPEN ABDOMEN; HIDRADENITIS SUPPURATIVA;
   MANAGEMENT; SKIN; INSTILLATION; EXPANSION; DEFECTS; RESECTION; STRETCH
AB Background/Objective. Loss of domain often complicates attempts at delayed wound closure in regions of high tension. Wound temporization with traction-assisted internal negative pressure wound therapy (NPWT), using bridging retention sutures, can minimize the effects of edema and elastic recoil that contribute to progressive tissue retraction over time. The investigators evaluated the safety and efficacy of this technique for complex wound closure. Materials and Methods. Between May 2015 and November 2015, 18 consecutive patients underwent staged reconstruction of complex and/or contaminated soft tissue defects utilizing either conventional NPWT or modified NPWT with instillation and continuous dermatotraction via bridging retention sutures. Instillation of antimicrobial solution was reserved for wounds containing infected/exposed hardware or prosthetic devices. Demographic data, wound characteristics, reconstructive outcomes, and complications were reviewed retrospectively. Results. Eighteen wounds were treated with traction-assisted internal NPWT using the conventional (n = 11) or modified instillation (n = 7) technique. Defects involved the lower extremity (n = 14), trunk (n = 3), and proximal upper extremity (n = 1), with positive cultures identified in 12 wounds (67%). Therapy continued for 3 to 8 days (mean, 4.3 days), resulting in an average wound surface area reduction of 78% (149 cm(2) vs. 33 cm2) at definitive closure. Seventeen wounds (94%) were closed directly, whereas the remaining defect required coverage with a local muscle flap and skin graft. At final follow-up (mean, 12 months), 89% of wounds remained closed. In 2 patients with delayed, recurrent peri-prosthetic infection (mean, 7.5 weeks), serial debridement/hardware removal mandated free tissue transfer for composite defect reconstruction. Conclusions. Traction-assisted internal NPWT provides a safe and effective alternative to reduce wound burden and facilitate definitive closure in cases where delayed reconstruction of high-tension wounds is planned.
C1 [DeFazio, Michael V.; Economides, James M.; Anghel, Ersilia L.; Mathis, Ryan K.; Barbour, John R.; Attinger, Christopher E.] MedStar Georgetown Univ Hosp, Ctr Wound Healing, Dept Plast Surg, Washington, DC USA.
C3 Georgetown University
RP DeFazio, MV (通讯作者)，MedStar Georgetown Univ Hosp, Dept Plast Surg, 3800 Reservoir Rd NW,1 PHC, Washington, DC 20007 USA.
EM Michael.V.DeFazio@gunet.georgetown.edu
RI Economides, James/L-1438-2019
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   Schessel ES, 2010, WOUNDS, V22, P151
   Takei T, 1998, PLAST RECONSTR SURG, V102, P247, DOI 10.1097/00006534-199807000-00044
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   Wilhelmi BJ, 1998, ANN PLAS SURG, V41, P215, DOI 10.1097/00000637-199808000-00019
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NR 37
TC 10
Z9 12
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2017
VL 29
IS 10
BP 289
EP +
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FV2BR
UT WOS:000424369500005
PM 28873059
DA 2026-07-24
ER
PT J
AU Yu, LL
   Kronen, RJ
   Simon, LE
   Stoll, CRT
   Colditz, GA
   Tuuli, MG
AF Yu, Lulu
   Kronen, Ryan J.
   Simon, Laura E.
   Stoll, Carolyn R. T.
   Colditz, Graham A.
   Tuuli, Methodius G.
TI Prophylactic negative-pressure wound therapy after cesarean is
   associated with reduced risk of surgical site infection: a systematic
   review and meta-analysis
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Review
DE antibiotics; cesarean delivery; dehiscence; endometritis; hospital
   readmission; meta-analysis; prophylactic negative-pressure wound
   therapy; seroma; surgical site infection
ID OBESE WOMEN; COMPLICATIONS; MANAGEMENT; DELIVERY; SECTION; INCISION;
   TRIAL
AB OBJECTIVE: The objective of the study was to assess the effect of prophylactic negative-pressure wound therapy on surgical site infections and other wound complications in women after cesarean delivery.
   DATA SOURCES: We searched Ovid Medline, Embase, SCOPUS, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov.
   STUDY ELIGIBILITY CRITERIA: We included randomized controlled trials and observational studies comparing prophylactic negative-pressure wound therapy with standard wound dressing for cesarean delivery.
   STUDY APPRAISAL AND SYNTHESIS METHODS: The primary outcome was surgical site infection after cesarean delivery. Secondary outcomes were composite wound complications, wound dehiscence, wound seroma, endometritis, and hospital readmission. Heterogeneity was assessed using Higgin's I-2. Relative risks with 95% confidence intervals were calculated using random-effects models.
   RESULTS: Six randomized controlled trials and 3 cohort studies in high-risk mostly obese women met inclusion criteria and were included in the meta-analysis. Six were full-text articles, 2 published abstracts, and 1 report of trial results in ClinicalTrials. gov. Studies were also heterogeneous in the patients included and type of negative-pressure wound therapy device. The risk of surgical site infection was significantly lower with the use of prophylactic negative-pressure wound therapy compared with standard wound dressing (7 studies: pooled risk ratio, 0.45; 95% confidence interval, 0.31-0.66; adjusted risk ratio, -6.0%, 95% confidence interval, -10.0% to -3.0%; number needed to treat, 17, 95% confidence interval, 10-34). There was no evidence of significant statistical heterogeneity (I-2 = 9.9%) or publication bias (Egger P =.532). Of the secondary outcomes, only composite wound complications were significantly reduced in patients receiving prophylactic negative-pressure wound therapy compared with standard dressing (9 studies: pooled risk ratio, 0.68, 95% confidence interval, 0.49-0.94).
   CONCLUSION: Studies on the effectiveness of prophylactic negative-pressure wound therapy at cesarean delivery are heterogeneous but suggest a reduction in surgical site infection and overall wound complications. Larger definitive trials are needed to clarify the clinical utility of prophylactic negative-pressure wound therapy after cesarean delivery.
C1 [Yu, Lulu; Kronen, Ryan J.; Colditz, Graham A.] Washington Univ, Sch Med, St Louis, MO 63110 USA.
   [Simon, Laura E.] Washington Univ, Sch Med, Becker Med Lib, St Louis, MO USA.
   [Stoll, Carolyn R. T.] Washington Univ, Sch Med, Dept Surg, Div Publ Hlth Sci, St Louis, MO 63110 USA.
   [Colditz, Graham A.] Washington Univ, Sch Med, Inst Publ Hlth, St Louis, MO USA.
   [Tuuli, Methodius G.] Washington Univ, Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Washington
   University (WUSTL); Washington University (WUSTL); Washington University
   (WUSTL)
RP Yu, LL (通讯作者)，Washington Univ, Sch Med, St Louis, MO 63110 USA.
EM lulu.yu@wustl.edu
RI Colditz, Graham/A-3963-2009; Simon, Laura/AAN-2353-2021
OI Colditz, Graham/0000-0002-7307-0291; Simon, Laura/0000-0002-3760-6810
FU Foundation for Barnes Jewish Hospital; National Institutes of Health
   [U01HD077384-03, 1R01HD086007-01]; Acelity, manufacturers of Prevena
FX Dr Colditz is supported in part by the Foundation for Barnes Jewish
   Hospital. Dr. Tuuli is supported by National Institutes of Health grants
   U01 (U01HD077384-03) and R01 (1R01HD086007-01). Dr Tuuli received
   supplemental research grant funding from Acelity, manufacturers of
   Prevena.
CR [Anonymous], INNOVATIONS ADV WOUN
   [Anonymous], PROPHYLACTIC INCISIO
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NR 31
TC 66
Z9 73
U1 0
U2 12
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD FEB
PY 2018
VL 218
IS 2
BP 200
EP +
DI 10.1016/j.ajog.2017.09.017
PG 12
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FV4JB
UT WOS:000424538300009
PM 28951263
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Landoni, G
   Lomivorotov, V
   Silvietti, S
   Neto, CN
   Pisano, A
   Alvaro, G
   Hajjar, LA
   Paternoster, G
   Riha, H
   Monaco, F
   Szekely, A
   Lembo, R
   Asian, NA
   Affronti, G
   Likhvantsev, V
   Amarelli, C
   Fominskiy, E
   Redaelli, MB
   Putzu, A
   Baiocchi, M
   Ma, J
   Bono, G
   Camarda, V
   Covello, RD
   Di Tomasso, N
   Labonia, M
   Leggieri, C
   Lobreglio, R
   Monti, G
   Mura, P
   Scandroglio, AM
   Pasero, D
   Turi, S
   Roasio, A
   Votta, CD
   Saporito, E
   Riefolo, C
   Sartini, C
   Brazzi, L
   Bellomo, R
   Zangrillo, A
AF Landoni, Giovanni
   Lomivorotov, Vladimir
   Silvietti, Simona
   Neto, Caetanor Nigro
   Pisano, Antonio
   Alvaro, Gabriele
   Hajjar, Ludmilla Abrahao
   Paternoster, Gianluca
   Riha, Hynek
   Monaco, Fabrizio
   Szekely, Andrea
   Lembo, Rosalba
   Asian, Nesrin A.
   Affronti, Giovanni
   Likhvantsev, Valery
   Amarelli, Cristiano
   Fominskiy, Evgeny
   Redaelli, Martina Baiardo
   Putzu, Alessandro
   Baiocchi, Massimo
   Ma, Jun
   Bono, Giuseppe
   Camarda, Valentina
   Covello, Remo Daniel
   Di Tomasso, Nora
   Labonia, Miriam
   Leggieri, Carlo
   Lobreglio, Rosetta
   Monti, Giacomo
   Mura, Paolo
   Scandroglio, Anna Mara
   Pasero, Daniela
   Turi, Stefano
   Roasio, Agostino
   Votta, Carmine D.
   Saporito, Emanuela
   Riefolo, Claudio
   Sartini, Chiara
   Brazzi, Luca
   Bellomo, Rinaldo
   Zangrillo, Alberto
TI Nonsurgical Strategies to Reduce Mortality in Patients Undergoing
   Cardiac Surgery: An Updated Consensus Process
SO JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
LA English
DT Article
DE cardiac surgery; perioperative; consensus; mortality; mortality
   reduction; review
ID INTRAAORTIC BALLOON PUMP; ACUTE KIDNEY INJURY; RANDOMIZED
   CONTROLLED-TRIAL; POSTOPERATIVE COMPLICATIONS; BYPASS SURGERY;
   INTENSIVE-CARE; LEVOSIMENDAN; METAANALYSIS; SURVIVAL; MULTICENTER
AB Objective: A careful choice of perioperative care strategies is pivotal to improve survival in cardiac surgery. However, there is no general agreement or particular attention to which nonsurgical interventions can reduce mortality in this setting. The authors sought to address this issue with a consensus-based approach.
   Design: A systematic review of the literature followed by a consensus-based voting process.
   Setting: A web-based international consensus conference.
   Participants: More than 400 physicians from 52 countries participated in this web-based consensus conference.
   Interventions: The authors identified all studies published in peer-reviewed journals that reported on interventions with a statistically significant effect on mortality in the setting of cardiac surgery through a systematic Medline/PubMed search and contacts with experts. These studies were discussed during a consensus meeting and those considered eligible for inclusion in this study were voted on by clinicians worldwide.
   Measurements and Main Results: Eleven interventions finally were selected: 10 were shown to reduce mortality (aspirin, glycemic control, high volume surgeons, prophylactic intra-aortic balloon pump, levosimendan, leuko-depleted red blood cells transfusion, noninvasive ventilation, tranexamic acid, vacuum-assisted closure, and volatile agents), whereas 1 (aprotinin) increased mortality. A significant difference in the percentages of agreement among different countries and a variable gap between agreement and clinical practice were found for most of the interventions.
   Conclusions: This updated consensus process identified 11 nonsurgical interventions with possible survival implications for patients undergoing cardiac surgery. This list of interventions may help cardiac anesthesiologists and intensivists worldwide in their daily clinical practice and can contribute to direct future research in the field. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Landoni, Giovanni; Silvietti, Simona; Monaco, Fabrizio; Lembo, Rosalba; Affronti, Giovanni; Redaelli, Martina Baiardo; Camarda, Valentina; Di Tomasso, Nora; Leggieri, Carlo; Monti, Giacomo; Scandroglio, Anna Mara; Turi, Stefano; Votta, Carmine D.; Riefolo, Claudio; Sartini, Chiara; Zangrillo, Alberto] IRCCS San Raffaele Sci Inst, Dept Anesthesia & Intens Care, Milan, Italy.
   [Landoni, Giovanni; Zangrillo, Alberto] Univ Vita Salute San Raffaele, Milan, Italy.
   [Lomivorotov, Vladimir; Fominskiy, Evgeny] Minist Hlth, Siberian Biomed Res Ctr, Dept Anaesthesiol & Intens Care, Novosibirsk, Russia.
   [Neto, Caetanor Nigro] Dante Pazzanese Inst Cardiol, Sao Paulo, Brazil.
   [Pisano, Antonio] Monaldi Hosp, Azienda Osped Colli, Div Cardiac Anesthesia & Intens Care, Naples, Italy.
   [Alvaro, Gabriele; Labonia, Miriam] Policlin Univ Mater Domini, Dept Anesthesia & Intens Care, Catanzaro, Italy.
   [Hajjar, Ludmilla Abrahao] Univ Sao Paulo, InCor, Dept Cardiopneumol, Surg Intens Care, Sao Paulo, Brazil.
   [Paternoster, Gianluca] Osped San Carlo Borromeo Milano, Dept Cardiovasc Anaesthesia & Intens Care, Potenza, Italy.
   [Riha, Hynek] Inst Clin & Expt Med, Dept Anaesthesiol & Intens Care Med, Cardiothorac Anaesthesiol & Intens Care, Prague, Czech Republic.
   [Szekely, Andrea] Semmelweis Egyet, Dept Anesthesia & Intens Care, Budapest, Hungary.
   [Asian, Nesrin A.] Medipol Mega Univ Hosp, Dept Anesthesiol & Intens Care, Istanbul, Turkey.
   [Likhvantsev, Valery] Moscow Reg Clin & Res Inst, Dept Anesthesia & Intens Care, Moscow, Russia.
   [Amarelli, Cristiano] Monaldi Hosp, Dept Cardiovasc Surg & Transplants, Naples, Italy.
   [Putzu, Alessandro] Cardioctr Ticino, Dept Cardiovasc Anesthesia & Intens Care, Lugano, Switzerland.
   [Baiocchi, Massimo] S Orsola Malpighi Univ Hosp, Dept Anesthesia & Intens Care, Bologna, Italy.
   [Ma, Jun] Capital Med Univ, Beijing Anzhen Hosp, Ctr Anesthesiol, Beijing, Peoples R China.
   [Bono, Giuseppe; Saporito, Emanuela] Policlin Univ Mater Domini, Dept Anesthesia & Intens Care, Catanzaro, Italy.
   [Covello, Remo Daniel] ASST Valle Olona, Busto Arsizio Hosp, Anesthesia & Intens Care Unit, Varese, Italy.
   [Lobreglio, Rosetta; Pasero, Daniela; Brazzi, Luca] AOU Citta Salute & Sci, Dept Anesthesia & Intens Care, Turin, Italy.
   [Mura, Paolo] Policlin Duilio Casula AOU Cagliari, Dept Med Sci M Aresu, Dept Anesthesia, Cagliari, Italy.
   [Mura, Paolo] Policlin Duilio Casula AOU Cagliari, Dept Med Sci M Aresu, Intens Care Unit, Cagliari, Italy.
   [Roasio, Agostino] Osped Cardinal Massaia di Asti, Dept Anaesthesia & Intens Care, Asti, Italy.
   [Bellomo, Rinaldo] Univ Melbourne, Sch Med, Melbourne, Vic, Australia.
   [Brazzi, Luca] Univ Turin, Dept Surg Sci, Turin, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University; Ministry of Health of the Russian
   Federation; Meshalkin National Medical Research Center; Instituto Dante
   Pazzanese de Cardiologia; Universidade de Sao Paulo; San Carlo Borromeo
   Hospital; Institute for Clinical & Experimental Medicine (IKEM);
   Semmelweis University; Istanbul Medipol University; IRCCS Azienda
   Ospedaliero-Universitaria di Bologna; Capital Medical University;
   Ospedale di Busto Arsizio; A.O.U. Citta della Salute e della Scienza di
   Torino; University of Melbourne; University of Turin
RP Landoni, G (通讯作者)，IRCCS San Raffaele Sci Inst, Dept Anesthesia & Intens Care, Via Olgettina 60, I-20132 Milan, Italy.
EM landoni.giovanni@hsr.it
RI COVELLO, Remo Daniel/MIK-2019-2025; Monaco, Fabrizio/GZA-9167-2022;
   Sartini, Chiara/HGU-3723-2022; ZANGRILLO, Alberto/AAH-2037-2019;
   Likhvantsev, Valery/A-4893-2016; Amarelli, Cristiano/U-6804-2017;
   Székely, Andrea/AAD-9724-2020; Nigro Neto, Caetano/M-4649-2016; Brazzi,
   Luca/AAS-4978-2020; Baiocchi, Massimo/JLM-6794-2023; Di Tomasso,
   Nora/ABD-7006-2020; LANDONI, Giovanni/AAH-1881-2019; Abrahão Hajjar,
   Ludhmila/HKO-6270-2023; Saporito, Emanuela/AAH-5739-2021; Lomivorotov,
   Vladimir/L-7868-2014; turi, stefano/AAC-2115-2019; Monti,
   Giacomo/AAN-2213-2020; Riha, Hynek/AGT-5807-2022; Aslan, Nesrin
   Ahu/HJO-9019-2023; Fominskiy, Evgeny/D-9118-2014; Putzu,
   Alessandro/AAY-3754-2020; Pisano, Antonio/AAG-1028-2020; Bellomo,
   Rinaldo/F-2571-2011; pasero, daniela cristina/ABF-4731-2021; Roasio,
   Agostino/HLG-5137-2023
OI COVELLO, Remo Daniel/0000-0002-6696-5361; Monaco,
   Fabrizio/0000-0001-5186-1976; Sartini, Chiara/0000-0003-2053-8636;
   Camarda, Valentina/0000-0002-7082-7113; ZANGRILLO,
   Alberto/0000-0002-7687-7648; Likhvantsev, Valery/0000-0002-5442-6950;
   Amarelli, Cristiano/0000-0002-7949-7771; Nigro Neto,
   Caetano/0000-0001-8134-3440; Brazzi, Luca/0000-0001-7059-0622; Baiocchi,
   Massimo/0000-0001-7909-6399; Di Tomasso, Nora/0000-0001-5706-8928;
   LANDONI, Giovanni/0000-0002-8594-5980; Abrahão Hajjar,
   Ludhmila/0000-0001-5645-2055; Saporito, Emanuela/0000-0002-6200-2365;
   PATERNOSTER, GIANLUCA/0000-0002-4032-0821; Votta,
   Carmine/0000-0002-7408-9605; Lomivorotov, Vladimir/0000-0001-8591-6461;
   turi, stefano/0000-0001-7365-3510; LEGGIERI, Carlo/0000-0002-0910-889X;
   Monti, Giacomo/0000-0002-3885-9238; Riha, Hynek/0000-0002-9861-7361;
   Baiardo Redaelli, Martina/0000-0002-4232-1713; Fominskiy,
   Evgeny/0000-0002-3198-4458; Putzu, Alessandro/0000-0002-4943-450X;
   Pisano, Antonio/0000-0002-5118-444X; 
FU Orion Pharma; AbbVie; Pall; Tenax
FX M. Baiocchi, V. Lomivorotov, G. Monti, G. Paternoster, and H. Riha have
   received speaker fees from Orion Pharma, and G. Landoni has received
   speaker fees from AbbVie, Orion Pharma, Pall, and Tenax.
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NR 58
TC 35
Z9 40
U1 0
U2 19
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1053-0770
EI 1532-8422
J9 J CARDIOTHOR VASC AN
JI J. Cardiothorac. Vasc. Anesth.
PD FEB
PY 2018
VL 32
IS 1
BP 225
EP 235
DI 10.1053/j.jvca.2017.06.017
PG 11
WC Anesthesiology; Cardiac & Cardiovascular Systems; Respiratory System;
   Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Cardiovascular System & Cardiology; Respiratory System
GA FV6ZG
UT WOS:000424730300030
PM 29122431
OA Green Submitted
DA 2026-07-24
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI EWMA DOCUMENT: NEGATIVE PRESSURE WOUND THERAPY OVERVIEW, CHALLENGES AND
   PERSPECTIVES
SO JOURNAL OF WOUND CARE
LA English
DT Article
ID VACUUM-ASSISTED-CLOSURE; DIABETIC FOOT ULCERS; SURGICAL-SITE INFECTIONS;
   RANDOMIZED CONTROLLED-TRIAL; THICKNESS SKIN-GRAFTS; MICROVASCULAR
   BLOOD-FLOW; QUALITY-OF-LIFE; TEMPORARY ABDOMINAL CLOSURE; SZILAGYI GRADE
   III; ULTRASONOGRAPHY MORPHOLOGICAL ANALYSIS
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NR 673
TC 0
Z9 0
U1 0
U2 13
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PY 2017
VL 26
IS 3
SU S
BP S8
EP S154
PG 147
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FV7RX
UT WOS:000424783700001
DA 2026-07-24
ER
PT J
AU Almeida, JE
   Suárez, R
   Gibson, E
AF Almeida, Jorge E.
   Suarez, Rodolfo
   Gibson, Elaine
TI A histological analysis of chronic wounds treated with negative pressure
   wound therapy to aid healing: a case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE angiogenesis; chronic wounds; histopathological change; negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE
AB Objective: Our aim was to examine histopathological changes in three chronic wounds, and to assess whether the application of negative pressure wound therapy (NPWT) changes the wound bed environment.
   Method: -
   Results: We recruited three patients were recruited who had a nonhealing wounds in excess of eight weeks. Histopathological changes in the wound bed supported the evidence that NPWT changes the wound bed environment by reducing inflammatory damage and facilitating wound bed perfusion with angiogenesis.
   Conclusion: We suggest that NPWT is a valuable adjunct to aid chronic wound healing. In this case series, we observed histopathological changes and improvement in the wounds, following one week's treatment with NPWT. Further analysis should be done to demonstrate any interaction between the cells involved in the wound healing process is enhanced, growth factor performance is optimised and cell migration is achieved following NPWT, in order to facilitate the healing process.
C1 [Almeida, Jorge E.] Hosp Mexico, Head Wound Clin, San Jose, Costa Rica.
   [Suarez, Rodolfo] Hosp Mexico, Dept Dermatol, Dermatopathol Unit, San Jose, Costa Rica.
RP Almeida, JE (通讯作者)，Hosp Mexico, Head Wound Clin, San Jose, Costa Rica.
EM elainegibson52@hotmail.com
CR [Anonymous], WOUND REPAIR REG
   Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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NR 30
TC 9
Z9 12
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2018
VL 27
IS 2
SU S
BP S28
EP S34
DI 10.12968/jowc.2018.27.Sup2.S28
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FV7SG
UT WOS:000424784800005
PM 29419368
DA 2026-07-24
ER
PT J
AU Ferreira, APP
   Vide, SS
   Fernandes, TDF
   Coelho, PMBD
   Camacho, OF
AF Pinto Ferreira, Antonio Pedro
   Vide, Sergio Santos
   Fonseca Fernandes, Tiago David
   Barata de Silva Coelho, Pedro Miguel
   Camacho, Oscar Ferraz
TI Hyperbaric oxygen therapy as an adjuvant to source control in
   necrotizing soft tissue infections
SO UNDERSEA AND HYPERBARIC MEDICINE
LA English
DT Article
DE infectious diseases; necrotizing infections; gas gangrene; hyperbaric
   oxygen therapy; negative-pressure wound therapy; debridement
ID FASCIITIS REDUCES MORTALITY; VACUUM-ASSISTED CLOSURE; DIAGNOSIS;
   MANAGEMENT; SURVIVAL; SKIN
AB Introduction: Necrotizing soft tissue infections (NSTI) are rare but potentially lethal disorders, and adequate management is time-and resource-demanding. This study aims to assess whether variations in the treatment modalities - surgery, hyperbaric oxygen (HBO2) therapy and negative pressure wound therapy - had an impact on the length to definitive source control in NSTI patients who underwent HBO2.
   Methods: This is a retrospective study of all NSTI patients treated with hyperbaric oxygen therapy between March 2007 and May 2015 at Unidade Local de Saude de Matosinhos (ULSM) Hyperbaric Unit. A multiple linear regression model was used to assess the impact of different treatment modalities in the post-diagnosis time until source control.
   Results: 58 patients were included; overall mortality was 13.8%. Mean time until source control was 10.4 days (+/- 5.4). All patients were under empiric and broad-spectrum antibiotics on the day of diagnosis. Patients underwent an average of 0.62 (+/- 0.29) surgical interventions and 1.06 (+/- 0.52) HBO2 sessions per day. The regression model (R-2=0.86) showed that after adjusting for other covariates, doubling the number of HBO2 sessions per day shortened source control by five days (beta=-5.25; 95% CI -6.49 to -4.01), and for each day that HBO2 was delayed, source control was achieved one day later (beta = 1.03; 95% CI 0.82 to 1.24).
   Conclusion: More intensive HBO2 protocols with earlier and more frequent sessions shorten the time until definitive source control in necrotizing soft tissue infections, potentially lowering the impact of systemic effects of infection and complications associated with organ dysfunction.
C1 [Pinto Ferreira, Antonio Pedro; Fonseca Fernandes, Tiago David] Dept Anesthesiol, Matosinhos Local Hlth Unit, Hyperbar Med Unit, Matosinhos, Portugal.
   [Vide, Sergio Santos; Camacho, Oscar Ferraz] Dept Anesthesiol, Matosinhos Local Hlth Unit, Matosinhos, Portugal.
   [Barata de Silva Coelho, Pedro Miguel] Univ Fernando Pessoa, Oporto, Portugal.
C3 Universidade Fernando Pessoa
RP Ferreira, APP (通讯作者)，Dept Anesthesiol, Matosinhos Local Hlth Unit, Hyperbar Med Unit, Matosinhos, Portugal.
EM antonio.pedroferreira@ulsm.min-saude.pt
RI ; Vide, Sérgio/AAN-8341-2020
OI Ferreira, António Peo/0000-0001-7190-4742; Vide,
   Sérgio/0000-0002-8185-2250
CR Anaya DA, 2007, CLIN INFECT DIS, V44, P705, DOI 10.1086/511638
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NR 36
TC 3
Z9 5
U1 0
U2 9
PU UNDERSEA & HYPERBARIC MEDICAL SOC INC
PI DURHAM
PA 21 WEST COLONY PLACE, STE 280, DURHAM, NC 27705 USA
SN 1066-2936
J9 UNDERSEA HYPERBAR M
JI Undersea Hyperb. Med.
PD NOV-DEC
PY 2017
VL 44
IS 6
BP 535
EP 542
DI 10.22462/11.12.2017.4
PG 8
WC Marine & Freshwater Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Marine & Freshwater Biology; Research & Experimental Medicine
GA FW2GE
UT WOS:000425120200004
PM 29281190
DA 2026-07-24
ER
PT J
AU Gaus, M
   Rohn, K
   Roetting, AK
AF Gaus, Moritz
   Rohn, Karl
   Roetting, Anna K.
TI Applicability and effect of a vacuum-assisted wound therapy after median
   laparotomy in horses
SO PFERDEHEILKUNDE
LA English
DT Article
DE horse; ventral median laparotomy; colic; wound healing complication;
   negative pressure wound therapy; vacuum-assisted closure
ID NEGATIVE-PRESSURE; COMPLICATION RATES; SURGICAL INCISIONS; TERM
   SURVIVAL; PART 1; CLOSURE; RISK; INFECTIONS; PREVENTION; MANAGEMENT
AB In a randomized, prospective, clinical trial the applicability of a vacuum therapy system was evaluated at the ventral abdomen in 50 horses with laparotomy due to acute abdominal pain. The effects on the incidence of wound healing complications after ventral median laparotomy in horses with acute abdominal pain is described. The horses were allocated to the treatment or control group after laparotomy and equipped with a wound dressing and a vacuum (125 mmHg) or with the wound dressing alone. Relevant parameters were collected preoperatively, intraoperatively, six consecutive days postoperatively, and three and eight weeks after surgery. Pre-, intra- and postoperative parameters were not significantly different between the groups. Nine horses (36%) in the treatment group and four horses (16%) in the control group developed a wound healing complication. This difference was not statistically significant and neither were the differences in oedema formation and the occurrence of dehiscence. No significant differences concerning exudation, oedema or dehiscence were found between the groups three and eight weeks after surgery. Overall, the vacuum system used in this study is an easy to apply system for general use at the ventral abdomen of the horse, with good toleration by the patients. The results indicate that the use of vacuum therapy for primary closed wounds after median laparotomy has no beneficial effect on wound healing.
C1 [Gaus, Moritz; Roetting, Anna K.] Univ Vet Med Hannover, Equine Clin, Hannover, Germany.
   [Rohn, Karl] Univ Vet Med Hannover, Inst Biometry Epidemiol & Informat Proc, Hannover, Germany.
C3 University of Veterinary Medicine Hannover; University of Veterinary
   Medicine Hannover
RP Gaus, M (通讯作者)，Vet Univ Hannover Fdn, Clin Horses, Buenteweg 9, D-30559 Hannover, Germany.
EM moritz.gaus@tiho-hannover.de
FU KCI Medizinprodukte GmbH, Germany
FX This study was supported by KCI Medizinprodukte GmbH, Germany, with the
   supply of the vacuum pump systems. We would like to thank all our
   interns for their intense assistance throughout the study, especially
   for the wound dressing applications during night hours.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 32
TC 7
Z9 8
U1 0
U2 3
PU HIPPIATRIKA VERLAG MBH
PI STUTTGART
PA POSTFACH 102251, 70018 STUTTGART, GERMANY
SN 0177-7726
J9 PFERDEHEILKUNDE
JI Pferdeheilkunde
PD NOV-DEC
PY 2017
VL 33
IS 6
BP 563
EP 572
DI 10.21836/PEM20170604
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FW3JN
UT WOS:000425202800004
OA Bronze
DA 2026-07-24
ER
PT J
AU Prichayudh, S
   Thammacharoen, E
   Sriussadaporn, S
   Pak-art, R
   Sriussadaporn, S
   Kritayakirana, K
   Samorn, P
   Narueponjirakul, N
AF Prichayudh, Supparerk
   Thammacharoen, Eakkaluck
   Sriussadaporn, Suvit
   Pak-art, Rattaplee
   Sriussadaporn, Sukanya
   Kritayakirana, Kritaya
   Samorn, Pasurachate
   Narueponjirakul, Natawat
TI Wall vacuum-assisted closure technique for a complex enteroatmospheric
   fistula: report of a case
SO ASIAN BIOMEDICINE
LA English
DT Article
DE Enteroatmospheric fistula; negative pressure wound therapy;
   vacuum-assisted closure; wall VAC
ID OPEN ABDOMEN; MANAGEMENT; THERAPY
AB Background: An enteroatmospheric fistula (EAF) is a devastating complication of abdominal surgery. EAF wound care is uniformly problematic and burdensome because the fistula effluent is difficult to contain, causing several abdominal skin problems.
   Objectives: To report the case of a complex EAF in a patient in whom conventional wound care techniques failed to contain the fistula.
   Methods: We reviewed the patient's medical records and the novel wound care technique used to contain the fistula.
   Results: We report the use of a modified vacuum-assisted closure (VAC) technique, the "Wall VAC", for the wound care of a patient with a complex EAF having large and multiple fistula openings following multiple abdominal operations. The Wall VAC technique consists of (1) leveling the skin surrounding the EAF wound, (2) creating the Wall VAC using a rectangular-shaped VAC sponge with 2 suction systems, and (3) sealing the system with a plastic bag and incise drape. By using this technique, the fistula effluent was effectively contained and the abdominal skin was well protected. The system changed every 3 to 4 days.
   Conclusions: Our modified VAC technique, the "Wall VAC", is simple and effective in containing a large volume (3,000 to 4,000 mL) of fistula effluent and protecting the abdominal skin in a patient with a complex EAF. We recommend this particular technique as an alternative method for managing a complex EAF.
C1 [Prichayudh, Supparerk; Thammacharoen, Eakkaluck; Sriussadaporn, Suvit; Pak-art, Rattaplee; Sriussadaporn, Sukanya; Kritayakirana, Kritaya; Samorn, Pasurachate; Narueponjirakul, Natawat] Chulalongkorn Univ, Dept Surg, Fac Med, Bangkok 10330, Thailand.
C3 Chulalongkorn University
RP Prichayudh, S (通讯作者)，Chulalongkorn Univ, Dept Surg, Fac Med, Bangkok 10330, Thailand.
EM supparerk.p@chula.ac.th
CR Blair SG, 2015, AM SURGEON, V81, pE96
   Bobkiewicz A, 2017, INT WOUND J, V14, P255, DOI 10.1111/iwj.12597
   Di Saverio S, 2015, J AM COLL SURGEONS, V220, pE23, DOI 10.1016/j.jamcollsurg.2014.11.020
   Mintziras I, 2016, LANGENBECK ARCH SURG, V401, P619, DOI 10.1007/s00423-016-1443-y
   Ozer MT, 2014, INT WOUND J, V11, P22, DOI 10.1111/iwj.12308
   Prichayudh S, 2011, SURG TODAY, V41, P72, DOI 10.1007/s00595-009-4202-7
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NR 9
TC 1
Z9 1
U1 0
U2 4
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1905-7415
EI 1875-855X
J9 ASIAN BIOMED
JI Asian Biomed.
PD JUN
PY 2017
VL 11
IS 3
BP 261
EP 265
DI 10.5372/1905-7415.1103.557
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FW4MR
UT WOS:000425288200008
DA 2026-07-24
ER
PT J
AU Ehrl, D
   Heidekrueger, PI
   Broer, PN
   Erne, HC
AF Ehrl, Denis
   Heidekrueger, Paul I.
   Broer, P. Niclas
   Erne, Holger C.
TI Topical Negative Pressure Wound Therapy of Burned Hands: Functional
   Outcomes
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE;
   PROGRESSION; GLOVE; RECONSTRUCTION; DISABILITIES; MANAGEMENT; DIFFUSION;
   AUTOGRAFT
AB Extensive partial-and full-thickness burns, especially of the hands, continue to pose a surgical challenge. With improved knowledge regarding fluid balance, burn pathophysiology, and lately also given the introduction of topical negative pressure wound (TNPW) therapy, treatment regimes have changed in many burn centers. The authors evaluated the results regarding long-term outcomes of patients with partial-and full-thickness burns of the hands treated with TNPW. Over a period of 72 months, 51 patients with 80 hand burns received TNPW treatment. Medical records of all patients were reviewed retrospectively. All patients were further invited by letter, telephone, and/or email to participate in follow-up examinations. Finally, 30 patients with 47 involved hands participated in this study. Follow-up examinations were performed at a mean of 35 (range: 14-72) months postinjury. Measurements regarding the ability to completely dorsally extend the fingers and complete active fist closure showed no restrictions in 85.1 and 78.7% of cases. Mean Disabilities of the Arm, Shoulder, and Hand score among all patients was 13.8 (range: 0-35.8). Regarding the quality of the scars of the hand, 41 hands showed good quality with no signs of hypertrophic scar formation and 6 hands showed acceptable quality of scars with partial hypertrophic scar formation. In the authors' experience, TNPW therapy is a safe and effective modality to treat burns of the hand.
C1 [Ehrl, Denis; Heidekrueger, Paul I.; Broer, P. Niclas] Tech Univ Munich, Acad Teaching Hosp, StKM Klinikum Bogenhausen, Dept Plast Reconstruct Hand & Burn Surg, Munich, Germany.
   [Erne, Holger C.] Tech Univ Munich, Klinikum Rechts Isar, Dept Plast Surg & Hand Surg, Munich, Germany.
C3 Technical University of Munich; Munchen Klinik; Technical University of
   Munich
RP Ehrl, D (通讯作者)，Tech Univ Munich, Bogenhausen Acad Hosp, Dept Plast Reconstruct Hand & Burn Surg, Englschalkingerstr 77, D-81925 Munich, Germany.
EM Denis.Ehrl@klinikum-muenchen.de
RI ; Broer, Niclas/AAF-6580-2019; Heidekrueger, Paul/AAC-8342-2022
OI Ehrl, Denis/0000-0001-9394-8412; 
CR Adamkova M, 2005, Acta Chir Plast, V47, P24
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NR 43
TC 11
Z9 12
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2018
VL 39
IS 1
BP 121
EP 128
DI 10.1097/BCR.0000000000000557
PG 8
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA FW4UM
UT WOS:000425310400017
PM 28368916
DA 2026-07-24
ER
PT J
AU Gonzalez, MG
   Beloy, IC
   Dovigo, AG
   Fortes, LM
   Carbonell, TD
   Pita-Fernández, S
   Bouzán, JC
AF Garcia Gonzalez, Miriam
   Casal Beloy, Isabel
   Gomez Dovigo, Alba
   Miguez Fortes, Lorena
   Dargallo Carbonell, Teresa
   Pita-Fernandez, Salvador
   Carames Bouzan, Jesus
TI Negative Pressure Wound Therapy for a Complicated Abdominal Laparotomy
   in Neonatal Necrotizing Enterocolitis: A Case Report
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case report; neonate; necrotizing enterocolitis; surgical wound
   dehiscence; negative pressure wound therapy
ID BIRTH-WEIGHT INFANTS; PROSPECTIVE COHORT; PRETERM INFANTS; OPEN ABDOMEN;
   MANAGEMENT; CHILDREN; TRIALS; CARE
AB Necrotizing enterocolitis (NEC) is the most common surgical emergency in neonatal intensive care units, and patients who require surgery have high mortality and morbidity rates. The utility of negative pressure in the management of adults with complicated abdominal wounds has been documented, but there are few reports describing the use of negative pressure wound therapy (NPWT) in children or following neonatal surgery. The case of a 6 day old, 5-weeks premature neonate with NEC is presented. An exploratory midline laparotomy was performed on day 3 of life owing to rectal bleeding and abdominal distension that did not respond to gastric decompression, bowel rest, and intravenous antibiotics. Ten (10) cm of necrosis in the distal ileum were noted and resected; in addition, an ileostomy was performed, and a Penrose drain was left in the surgical site. On postoperative day 5, the laparotomy dehisced. Continuous NPWT (50 mm Hg) was initiated and changed owing to patient tolerance to intermittent therapy (5 minutes on, 30 seconds off) at 80 mm Hg. By postoperative day 11, granulation tissue formation was complete. No surgical procedures were required for the complete closure of the abdominal wall, and no adverse reactions were noted. The baby was discharged from the hospital on postop day 15. In this patient, the use of negative pressure was found to be safe and facilitated management of a complicated abdominal wound in the presence of a stoma and the formation of healthy granulation tissue. Additional research is needed to help clinicians provide optimal, evidence-based care for dehisced wounds in this vulnerable population.
C1 [Garcia Gonzalez, Miriam; Casal Beloy, Isabel; Miguez Fortes, Lorena; Dargallo Carbonell, Teresa; Carames Bouzan, Jesus] Univ Hosp A Coruna, Dept Pediat Surg, La Coruna, Spain.
   [Gomez Dovigo, Alba] Quiron Hosp A Coruna, La Coruna, Spain.
   [Pita-Fernandez, Salvador] Univ Hosp A Coruna, Clin Epidemiol & Biostat Res Grp, La Coruna, Spain.
C3 Complejo Hospitalario Universitario A Coruna; Complejo Hospitalario
   Universitario A Coruna
RP Gonzalez, MG (通讯作者)，Univ Hosp A Coruna, Dept Pediat Surg, La Coruna, Spain.; Gonzalez, MG (通讯作者)，Complejo Hosp Univ A Coruna, Xubias Abajo S-N, La Coruna 15006, Spain.
EM Miriam.ciruped@gmail.com
RI Casal-Beloy, Isabel/ABF-7555-2021; pita-fernandez, salvador/K-2191-2014;
   /AAF-5983-2021
OI Casal-Beloy, Isabel/0000-0003-1762-8382; 
CR Aguayo P, 2009, J SURG RES, V157, P275, DOI 10.1016/j.jss.2009.06.005
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NR 18
TC 3
Z9 6
U1 1
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2017
VL 63
IS 6
BP 34
EP 38
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FW5UV
UT WOS:000425385500003
PM 28657898
DA 2026-07-24
ER
PT J
AU Sun, XF
   Wu, SH
   Xie, T
   Zhang, JP
AF Sun, Xiaofang
   Wu, Shaohan
   Xie, Ting
   Zhang, Jianping
TI Combing a novel device and negative pressure wound therapy for managing
   the wound around a colostomy in the open abdomen: A case report
SO MEDICINE
LA English
DT Article
DE a novel device; colostomy; negative pressure wound therapy; open
   abdomen; ostomy
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL CLOSURE; MANAGEMENT; METAANALYSIS;
   PERITONITIS; MORTALITY; FISTULA
AB Rationale:An open abdomen complicated with small-bowel fistulae becomes a complex wound for local infection, systemic sepsis and persistent soiling irritation by intestinal content. While controlling the fistulae drainage, protecting surrounding skin, healing the wound maybe a challenge.Patient concerns:In this paper we described a 68-year-old female was admitted to emergency surgery in general surgery department with severe abdomen pain. Resection part of the injured small bowel, drainage of the intra-abdominal abscess, and fashioning of a colostomy were performed.Diagnoses:She failed to improve and ultimately there was tenderness and lot of pus under the skin around the fistulae. The wound started as a 3-cm(2) lesion and progressed to a 6x13 (78cm(2)) around the stoma.Interventions:In our case we present a novel device for managing colostomy wound combination with negative pressure wound therapy.Outcomes:This tube allows for an effective drainage of small-bowel secretion and a safe build-up of granulation tissue. Also it could be a barrier between the bowel suction point and foam.Lessons:Management of open abdomen wound involves initial dressing changes, antibiotic use and cutaneous closure. When compared with traditional dressing changes, the NPWT offers several advantages including increased granulation tissue formation, reduction in bacterial colonization, decreased of bowel edema and wound size, and enhanced neovascularization.
C1 [Sun, Xiaofang; Zhang, Jianping] Jiaxing Univ, Hosp 2, Dept Dermatol, 1518 Huancheng North Rd, Jiaxing 314000, Zhejiang, Peoples R China.
   [Wu, Shaohan] Jiaxing Univ, Hosp 2, Dept Gen Surg, Jiaxing, Zhejiang, Peoples R China.
   [Xie, Ting] Shanghai Jiao Tong Univ, Sch Med, Wound Healing Dept, Shanghai Peoples Hosp 9, Shanghai, Peoples R China.
C3 Jiaxing University; Jiaxing University; Shanghai Jiao Tong University
RP Zhang, JP (通讯作者)，Jiaxing Univ, Hosp 2, Dept Dermatol, 1518 Huancheng North Rd, Jiaxing 314000, Zhejiang, Peoples R China.
EM doctorjpzhang@163.com
FU National Natural Science Foundation of China [81671917]; Science and
   Technology Program of Jiaxing [2017AY33037]
FX This study was supported by grants from the National Natural Science
   Foundation of China (81671917), the Science and Technology Program of
   Jiaxing (2017AY33037).
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NR 15
TC 7
Z9 10
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2017
VL 96
IS 52
AR e9370
DI 10.1097/MD.0000000000009370
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FW5VC
UT WOS:000425386300021
PM 29384913
DA 2026-07-24
ER
PT J
AU Ribeiro, LM
   Guerra, AS
AF Ribeiro, Luis Mata
   Guerra, Ana Silva
TI Hidradenitis Suppurativa: Combined Treatment with Dermal Template, Skin
   Graft and Negative Pressure Wound Therapy, a Case Study
SO ACTA MEDICA PORTUGUESA
LA Portuguese
DT Article
DE Hidradenitis Suppurativa; Negative-Pressure Wound Therapy; Skin
   Transplantation
ID AXILLARY HIDRADENITIS; SURGICAL-TREATMENT; ACNE INVERSA; SURGERY;
   DRESSINGS; FLAP
AB Hidrosadenitis supurativa is a chronic inflammatory disease with great physical and psychological impact. Although conservative treatments may be effective in mild forms of the disease, extensive surgical resection and reconstruction are necessary in more severe forms of the disease. The purpose of this paper is to describe our two-stage reconstructive procedure regarding this kind of disease. We present a clinical case of a patient with severe, bilateral axillary hidrosadenitis. In the first surgical step we excised the lesions and applied the artificial dermis secured with negative pressure wound therapy. In the second step we used a split thickness skin graft to close the wound and again applied negative pressure wound therapy. The graft take was very good, without complications. The cosmetic outcome is acceptable and shoulder mobility was not compromised. No recurrence was detected (nine months follow up).
C1 [Ribeiro, Luis Mata; Guerra, Ana Silva] Ctr Hosp Lisboa Cent, Hosp Sao Jose, Serv Cirurgia Plast Reconstrut & Estet, Lisbon, Portugal.
   [Guerra, Ana Silva] Hosp CUF Descobertas, Serv Cirurgia Plast Reconstrut & Estet, Lisbon, Portugal.
C3 Universidade de Lisboa; Centro Hospitalar de Lisboa Central, EPE
RP Ribeiro, LM (通讯作者)，Ctr Hosp Lisboa Cent, Hosp Sao Jose, Serv Cirurgia Plast Reconstrut & Estet, Lisbon, Portugal.
EM Luis1989ribeiro@gmail.com
RI Mata Ribeiro, Luís/AAZ-2661-2020
OI Mata Ribeiro, Luís/0000-0002-4714-8737
CR [Anonymous], 1989, Axillary hyperhidrosis, apocrine bromhidrosis, hidradenitis suppurativa and familial benign pemphigus: surgical approach
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NR 14
TC 1
Z9 3
U1 0
U2 1
PU ORDEM MEDICOS
PI LISBON
PA AV ALMIRANTE GAGO COUTINHO, 151, LISBON, 1749-084, PORTUGAL
SN 1646-0758
J9 ACTA MEDICA PORT
JI Acta Medica Port.
PD JAN
PY 2018
VL 31
IS 1
BP 59
EP 62
DI 10.20344/amp.8656
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FW6YF
UT WOS:000425465600011
PM 29573770
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Begkas, D
   Michelarakis, J
   Mirtsios, H
   Deimedes, P
   Bougiouklis, D
AF Begkas, Dimitrios
   Michelarakis, John
   Mirtsios, Hristos
   Deimedes, Panagiotis
   Bougiouklis, Dimitrios
TI The role of negative pressure wound therapy in salvaging a six-year-old
   child's crushed foot - A case report
SO FOOT AND ANKLE SURGERY
LA English
DT Article
DE Children trauma; Foot; Limb salvage; Mangled extremity; Negative
   pressure wound therapy
ID MANGLED EXTREMITY; LIMB SALVAGE; AMPUTATION; INDEX; RECONSTRUCTION;
   DECISION; UTILITY; INJURY; TRAUMA; SCORES
AB Crushed extremity is an infrequent injury in children and represents a major challenge for the orthopaedic surgeon. Sometimes the decision making process, whether to amputate or save a limb, is very difficult. Several scoring systems have been developed in order to determine the fate of crushed extremities, but they are not always predictive when patients are children. In the past few years, advances in bone and soft tissue reconstruction techniques have improved outcomes, even in the most extreme cases. Negative Pressure Wound Therapy has become an accepted option in the treatment of crushed limbs. We report a 6-year-old child with a crushed left foot from the running chain of his father's motorcycle. Early revascularization and stabilization along with multiple debridement and the application of Negative Pressure Wound Therapy leaded to salvage of the child's limb. At the end of one year follow up, he presented a very good functional and aesthetic result. (C) 2017 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
C1 [Begkas, Dimitrios; Michelarakis, John; Mirtsios, Hristos; Deimedes, Panagiotis; Bougiouklis, Dimitrios] Athens Gen Childrens Hosp Pan & Aglaia Kyriakou, Dept Orthopaed 2, Athens, Greece.
RP Begkas, D (通讯作者)，21 Saronikou Str, Athens 16345, Greece.
EM drdbegkas@gmail.com
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NR 24
TC 2
Z9 3
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1268-7731
EI 1460-9584
J9 FOOT ANKLE SURG
JI Foot Ankle Surg.
PD FEB
PY 2018
VL 24
IS 1
BP E1
EP E6
DI 10.1016/j.fas.2017.10.011
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA FX0ND
UT WOS:000425740600001
PM 29413782
DA 2026-07-24
ER
PT J
AU Bi, HD
   Khan, M
   Li, JH
   Pestana, IA
AF Bi, Hongda
   Khan, Mija
   Li, Junhui
   Pestana, Ivo A.
TI Use of Incisional Negative Pressure Wound Therapy in Skin-Containing
   Free Tissue Transfer
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE NPWT; free tissue transfer; cutaneous flap
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; MASTECTOMY FLAP
   NECROSIS; BREAST RECONSTRUCTION; VENOUS CONGESTION; LOWER-EXTREMITY;
   DIABETIC FOOT; MUSCLE FLAPS; GRAFTS; INFECTIONS
AB Background Negative pressure wound therapy (NPWT) was initially introduced for wound management, but its benefits have stimulated the investigation of its use in new clinical scenarios. Most recently, incisional NPWT has been shown to be a benefit. Incisional NPWT applied to skin-containing free tissue transfer has not been well defined. This may originate from concerns of dressing material obscuring frequent examination of the newly transferred tissue or risk of pedicle compression and potential for increased risk of tissue loss. We aim to describe incisional NPWT in cutaneous free tissue transfer.
   Methods An institutional review board-approved retrospective review of consecutive free tissue transfer patients was completed over a 3-year period. Free tissue transfer procedures were performed in standard manner. After fixation of the flap to the donor site with interrupted sutures, one or two drainage tubes were inserted in the subflap position. The surface of the flap was protected with Vaseline gauze followed by a 1 cm thick layer of sterile cotton. The vacuum-assisted closure (VAC) sponge (KCI, TX) was then placed in the standard fashion and negative pressure at -125mm Hg was initiated in a continuous mode. A window was routinely made over the flap's distal region to allow for serial flap examination. For extremity procedures, no splints were utilized, and patients were limited to motion in the hospital bed. NPWT was employed continuously for 7 days and subsequently removed along with operative drains.
   Results A total of 24 consecutive patients underwent free tissue transfer. The average patient age was 39.8 years with a mean body mass index of 23. Tobacco use was noted in 58% of patients in the series. The indication for the free tissue transfer included trauma ( N =21), malignancy ( N =2), and burn reconstruction ( N =1). The areas of reconstruction included scalp ( N =5), lower extremity ( N =11), and upper extremity ( N =8). Skin-containing free flaps employed consisted of the latissimus dorsi myocutaneous free flap ( N =16), anterolateral thigh free flap ( N =6), thoracodorsal artery perforator free flap ( N =1), and radial forearm free flap ( N =1). The average defect size reconstructed was 238.3 cm (2) with a mean operative time of 501 minutes. Postoperatively, patients remained in the hospital an average of 15.5 days (range: 9-32 days) with a mean follow-up of 8.1 months. No hematomas, seromas, surgical-site infections, or deep vein thrombosis/pulmonary embolism occurred in the series. None of the flaps required return to the operating room. There were no documented cases of partial or complete flap loss.
   Conclusions NPWT may be employed in a fashion similar to the standard incisional application. With this technique, serial flap examination remains possible and is not associated with pedicle compression or increased rates of flap loss. Interestingly, no splints were utilized with the VAC device which itself may serve as a relative immobilizer of an extremity.
C1 [Bi, Hongda; Li, Junhui] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai 200433, Peoples R China.
   [Khan, Mija; Pestana, Ivo A.] Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27109 USA.
C3 Naval Medical University; Wake Forest University
RP Li, JH (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai 200433, Peoples R China.
EM lissot@163.com
RI Pestana, Ivo Alexander/JMR-2324-2023
OI Pestana, Ivo Alexander/0000-0001-6272-4213
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
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NR 39
TC 26
Z9 35
U1 0
U2 12
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD MAR
PY 2018
VL 34
IS 3
BP 200
EP 205
DI 10.1055/s-0037-1608621
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FX1NO
UT WOS:000425819200006
PM 29112999
DA 2026-07-24
ER
PT J
AU Wu, JP
   Jiang, ZH
   Feng, XJ
   Jiang, JN
   Cheng, MH
AF Wu, Jian-Ping
   Jiang, Zhen-Huan
   Feng, Xiao-Jun
   Jiang, Jian-Nong
   Cheng, Mao-Hua
TI Negative Pressure Therapy in the Regeneration of the Sciatic Nerve Using
   Vacuum - Assisted Closure in a Rabbit Model
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Contingent Negative Variation; S100 Proteins; Wound Healing
ID WOUND THERAPY; SCHWANN-CELLS; INJURY; REPAIR
AB Background: The aim of this study was to investigate the effects of negative pressure therapy in the regeneration of the rabbit sciatic nerve using vacuum assisted closure (VAC).
   Material/Methods: Thirty male New Zealand white rabbits underwent surgical injury of the sciatic nerve, followed by negative pressure therapy using vacuum assisted closure (VAC), in three treatment groups: Group A: 0 kPa; Group B: -20 kPa; Group C: -40 kPa. At 12 weeks following surgery, the following factors were studied: motor nerve conduction velocity (MNCV); the number of myelinated nerve fibers; the wet weight of the gastrocnemius muscle. Gastrocnemius muscle and sciatic nerve tissue samples were studied for the expression of S100, and brain-derived neurotrophic factor (BDNF) using Western blot.
   Results: At 12 weeks following VAC treatment, the MNCV, number of myelinated nerve fibers, and wet weight of the gastrocnemius muscle showed significant differences between the groups (p<0.05), in the following order: Group B >Group A >Group C. The sciatic nerve at 12 weeks following VAC in Group B and Group C showed a significant increase in expression of S100 and BDNF when compared with Group A; no significant differences were detected between Group B and Group C results from Western blot at 12 weeks.
   Conclusions: The findings of this study, using negative pressure therapy in VAC in a rabbit model of sciatic nerve damage, have shown that moderate negative pressure was beneficial, but high values did not benefit sciatic nerve repair.
C1 [Wu, Jian-Ping; Jiang, Zhen-Huan; Jiang, Jian-Nong] Jiangsu Unvers, Yixing Hosp, Dept Orthopaed, Yixin, Jiangsu, Peoples R China.
   [Feng, Xiao-Jun] Xishan Peoples Hosp Wuxi, Wuxing, Jiangsu, Peoples R China.
   [Cheng, Mao-Hua] Affiliated Hosp Soochow 2, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China.
RP Jiang, JN (通讯作者)，Jiangsu Unvers, Yixing Hosp, Dept Orthopaed, Yixin, Jiangsu, Peoples R China.; Cheng, MH (通讯作者)，Affiliated Hosp Soochow 2, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China.
EM jiangjiannong@yxph.com; wujianping004@sina.com
RI JIANG, ZHENHUAN/KCD-7096-2024
FU Natural Science Foundation for Youth [81402220]; Wuxi Medical Talents
   grant [ZDRC018]
FX The present study was supported by a grant from the Natural Science
   Foundation for Youth (No. 81402220) and the Wuxi Medical Talents grant
   (No. ZDRC018)
CR [Anonymous], BREAST J
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NR 31
TC 0
Z9 0
U1 0
U2 6
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD FEB 19
PY 2018
VL 24
BP 1027
EP 1033
DI 10.12659/MSM.906696
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FX1OL
UT WOS:000425821500002
PM 29457605
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Yin, YC
   Zhang, RP
   Li, SL
   Guo, JL
   Hou, ZY
   Zhang, YZ
AF Yin, Yingchao
   Zhang, Ruipeng
   Li, Shilun
   Guo, Jialiang
   Hou, Zhiyong
   Zhang, Yingze
TI Negative-pressure therapy versus conventional therapy on split-thickness
   skin graft: A systematic review and meta-analysis
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Review
DE Negative-pressure therapy; Conventional therapy; Split-thickness skin;
   Meta-analysis
ID VACUUM-ASSISTED CLOSURE; FLAP DONOR SITE; WOUND THERAPY;
   CONTROLLED-TRIAL; BACTERIAL LOAD; MANAGEMENT
AB Objective: To compare the clinical outcomes of negative-pressure wound therapy (NPWT) versus conventional therapy on split-thickness skin after grafting surgery.
   Design: Meta-analysis.
   Background: Split-thickness skin grafts are widely used in reconstruction of large skin defects. Conventional therapy causes pain during dressing changing. NPWT is an alternative method to cover the wound bed.
   Methods: The Pubmed, Embase, and Cochrane databases were searched for randomized controlled trials (RCTs) or cohort studies for articles published between 1993 and April 2017 comparing NPWT to conventional wound therapy for split-thickness skin grafts. The rate of graft take was the primary outcome of this meta-analysis. Wound infection and reoperation rate of the wound were secondary outcomes. Data analysis was conducted using the Review Manager 5.3 software.
   Results: Five cohort studies and seven RCTs including 653 patients were eligible for inclusion. Patients treated with NPWT had a significantly higher rate of graft take compared to those treated with conventional therapy [MD=7.02, (95% CI 3.74, 10.31)] (P=.00). NPWT was associated with a reduction in reoperation [RR= 0.28, (95% CI 0.14, 0.55)] (P=.00). The reduction in wound infection was not significant [RR=0.63, (95% CI 0.31, 1.27)] (P=.20).
   Conclusion: Compared with conventional therapy, NPWT significantly increases the rate of graft take and reduces the rate of reoperation when applied to cover the wound bed with split-thickness skin graft. No significant impact on wound infection was found in this study.
C1 [Yin, Yingchao; Zhang, Ruipeng; Li, Shilun; Guo, Jialiang; Hou, Zhiyong; Zhang, Yingze] Hebei Med Univ, Hosp 3, Key Lab Biomech Hebei Prov, Dept Orthopaed Surg, 139 Ziqiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
C3 Hebei Medical University
RP Zhang, YZ (通讯作者)，Hebei Med Univ, Hosp 3, Key Lab Biomech Hebei Prov, Dept Orthopaed Surg, 139 Ziqiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
EM dryingchao@gmail.com; zhangruipengdoctor@126.com; lshilun@163.com;
   guojialiang11123@163.com; drzyhou@gmail.com; dr_yzzhang@126.com
OI Hou, Zhiyong/0000-0001-5838-4025; Zhang, Ruipeng/0000-0002-1702-8988;
   Yin, Yingchao/0000-0002-0989-9556
CR [Anonymous], 2015, Shock and Vibration, DOI [10.1155/2015/194230, DOI 10.2118/174384-MS, DOI 10.1155/2015/194230]
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NR 25
TC 84
Z9 101
U1 1
U2 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD FEB
PY 2018
VL 50
BP 43
EP 48
DI 10.1016/j.ijsu.2017.12.020
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FX2MW
UT WOS:000425895900008
PM 29292216
DA 2026-07-24
ER
PT J
AU Looby, MA
   Vogel, RI
   Bangdiwala, A
   Hyer, B
   Das, K
AF Looby, Maureen Ayers
   Vogel, Rachel Isaksson
   Bangdiwala, Ananta
   Hyer, Barbara
   Das, Kamalini
TI Prophylactic Negative Pressure Wound Therapy in Obese Patients Following
   Cesarean Delivery
SO SURGICAL INNOVATION
LA English
DT Article
DE tissue engineering; surgical oncology; evidence based medicine; surgery
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS
AB Objective. Negative pressure therapy (NPT) offers the potential to reduce infection in obese patients. The goal of this study was to explore the association between NPT use and infection after cesarean delivery among obese women. Methods: We initiated a hospital protocol wherein women with a body mass index (BMI) of 40 kg/m(2) or greater who delivered after January 1, 2011 were to receive NPT following cesarean section. A retrospective comparison of surgical site infection (SSI) in women receiving the intervention to a similar group with a BMI of 40 kg/m(2) or greater, a historical control group of women who delivered before January 1, 2011. Incidence of SSI was compared between time periods using logistic regression models. Results. A total of 233 patients in the preintervention (control) group and 234 patients in the intervention group were included in the analysis. In the control group, 23 (9.9%) developed SSI, compared with 13 (5.6%) in the intervention group. After adjustment for potential confounding factors, women in the postintervention period experienced a statistically significant reduction in SSI rates (adjusted odds ratio =0.45, 95% CI = 0.22-0.95); P = .04). Conclusion. Implementation of a hospital protocol of NPT following cesarean delivery in obese women resulted in reduced incidence of postoperative SSI. This study suggests that using NPT after cesarean delivery in women with a BMI 40 kg/m(2) is an efficacious method to reduce incidence of postoperative wound infections.
C1 [Looby, Maureen Ayers; Hyer, Barbara; Das, Kamalini] HealthPartners Dept Obstet & Gynecol, 205 South Wabasha St, St Paul, MN 55107 USA.
   [Looby, Maureen Ayers; Vogel, Rachel Isaksson; Bangdiwala, Ananta] Univ Minnesota, Minneapolis, MN USA.
C3 University of Minnesota System; University of Minnesota Twin Cities
RP Das, K (通讯作者)，HealthPartners Dept Obstet & Gynecol, 205 South Wabasha St, St Paul, MN 55107 USA.
EM kamalini.x.das@healthpartners.com
OI Das, Kamalini/0000-0003-4343-467X; Vogel, Rachel/0000-0003-0149-8464
FU Regions Hospital Red Fund from HealthPartners Medical Group [RG
   1415301]; NIH [P30 CA77598]; National Center for Advancing Translational
   Sciences of the National Institutes of Health [UL1TR000114]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported in part by the Regions Hospital Red Fund RG 1415301 from
   HealthPartners Medical Group. Statistical data analysis was supported in
   part by NIH grant P30 CA77598 utilizing the Biostatistics and
   Bioinformatics Core shared resource of the Masonic Cancer Center,
   University of Minnesota and by the National Center for Advancing
   Translational Sciences of the National Institutes of Health Award Number
   UL1TR000114.
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NR 18
TC 10
Z9 12
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD FEB
PY 2018
VL 25
IS 1
BP 43
EP 49
DI 10.1177/1553350617736652
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FX3SP
UT WOS:000425992900007
PM 29090986
DA 2026-07-24
ER
PT J
AU Bonnevialle, P
AF Bonnevialle, P.
TI Operative treatment of early infection after internal fixation of limb
   fractures (exclusive of severe open fractures)
SO ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
LA English
DT Article; Proceedings Paper
CT Congress of the French-Society-for-Orthopedic-Surgery-and-Traumatology
   (SofCOT)
CY NOV 08-11, 2016
CL Paris, FRANCE
SP French Soc Orthoped Surg & Traumatol
DE Surgical-site infection; Superficial incisional surgical-site infection;
   Deep incisional surgical-site infection; ORIF for limb fractures;
   Complications; Nosocomial infection; Antibiotic therapy; Microbiological
   sampling; Multidisciplinary management
ID DEVICE-ASSOCIATED INFECTIONS; SURGICAL SITE INFECTION; RISK-FACTORS;
   JOINT INFECTION; CASE SERIES; SURGERY; COMPLICATIONS; PREVENTION;
   DIAGNOSIS; IMPLANTS
AB Early infection after open reduction and internal fixation (ORIF) of a limb bone is defined as bacteriologically documented, deep and/or superficial surgical-site infection (SSI) diagnosed within 6 months after the surgical procedure. This interval is arbitrarily considered sufficient to obtain fracture healing. The treatment of early infection after ORIF should be decided by a multidisciplinary team. The principles are the same as for revision arthroplasty. Superficial SSIs should be differentiated from deep SSIs, based on the results of bacteriological specimens collected using flawless technique. A turning point in the local microbial ecology occurs around the third or fourth week, when a biofilm develops around metallic implants. This biofilm protects the bacteria. The treatment relies on both non-operative and operative measures, which are selected based on the time to occurrence of the infection, condition of the soft tissues, and stage of bone healing. Both the surgical strategy and the antibiotic regimen should be determined during a multidisciplinary discussion. When treating superficial SSIs after ORIF, soft-tissue management is the main challenge. The treatment differs according to whether the hardware is covered or exposed. Defects in the skin and/or fascia can be managed using reliable reconstructive surgery techniques, either immediately or after a brief period of vacuum-assisted closure. In deep SSIs, deciding whether to leave or to remove the hardware is difficult. If the hardware is removed, the fracture site can be stabilised provisionally using either external fixation or a cement rod. Once infection control is achieved, several measures can be taken to stimulate bone healing before the end of the classical 6-month interval. If the hardware was removed, then internal fixation must be performed once the infection is eradicated. (C) 2016 Published by Elsevier Masson SAS.
C1 [Bonnevialle, P.] CHU Toulouse, Hop PP Riquet, Dept Orthopedie Traumatol, Pl Baylac, F-31052 Toulouse, France.
C3 Universite de Toulouse (EPE); CHU de Toulouse; Communaute d'universites
   et etablissements de Toulouse (Comue)
RP Bonnevialle, P (通讯作者)，CHU Toulouse, Hop PP Riquet, Dept Orthopedie Traumatol, Pl Baylac, F-31052 Toulouse, France.
EM ventre.s@chu-toulouse.fr
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NR 39
TC 16
Z9 28
U1 0
U2 4
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1877-0568
J9 ORTHOP TRAUMATOL-SUR
JI Orthop. Traumatol.-Surg. Res.
PD FEB
PY 2017
VL 103
IS 1
SU S
BP S67
EP S73
DI 10.1016/j.otsr.2016.06.019
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics; Surgery
GA FX5QU
UT WOS:000426135500008
PM 28057476
DA 2026-07-24
ER
PT J
AU Robert, N
AF Robert, N.
TI Negative pressure wound therapy in orthopaedic surgery
SO ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
LA English
DT Article; Proceedings Paper
CT Congress of the French-Society-for-Orthopedic-Surgery-and-Traumatology
   (SofCOT)
CY NOV 08-11, 2016
CL Paris, FRANCE
SP French Soc Orthoped Surg & Traumatol
DE Negative pressure wound therapy; Healing; Acute wound; Chronic wound;
   Orthopaedics
ID VACUUM-ASSISTED CLOSURE; FIBRIN MATRIX; PROLIFERATION; INSTILLATION;
   FOUNDATION
AB Negative pressure wound therapy (NPWT) consists in applying subatmospheric pressure to a wound that is sealed off by a specially designed dressing and connected by a tube to a suction pump and drainage collection system. Skin defects are extremely common in orthopaedic and trauma surgery. NPWT is valuable across a range of indications. Proven effects include an increase in blood flow, stimulation of angiogenesis, and a decrease in wound surface area. NPWT can be used to treat post-traumatic and surgical wounds, burns, and chronic wounds such as pressure sores and ulcers. The lower frequency of dressing changes with NPWT lightens the staff workload. The French high authority for health (HAS) has issued good practice guidelines for the use of NPWT in specific and limited indications. NPWT has benefited from the introduction of several technological improvements such as silicone interfaces, foam dressings with various densities and pore sizes, and irrigation systems. The result is greater adaptability to each specific situation. Nevertheless, NPWT is not appropriate in every case and cannot replace a necessary surgical procedure. The goal of this work is to review the principles, practical modalities, and indications of NPWT. (c) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Robert, N.] Hop Prive Ouest Parisien, Inst Chirurg Main Ouest Parisien, 14 Rue Castigl Lago, F-78190 Trappes, France.
   [Robert, N.] Urgences Mains Paris Peupliers, 8 Pl Abbe Georges Henocque, F-75013 Paris, France.
RP Robert, N (通讯作者)，Hop Prive Ouest Parisien, Inst Chirurg Main Ouest Parisien, 14 Rue Castigl Lago, F-78190 Trappes, France.
EM drnicolasrobert@gmail.com
CR Altintas B, 2015, INT WOUND J, V12, P662, DOI 10.1111/iwj.12198
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NR 30
TC 42
Z9 64
U1 0
U2 17
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1877-0568
J9 ORTHOP TRAUMATOL-SUR
JI Orthop. Traumatol.-Surg. Res.
PD FEB
PY 2017
VL 103
IS 1
SU S
BP S99
EP S103
DI 10.1016/j.otsr.2016.04.018
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics; Surgery
GA FX5QU
UT WOS:000426135500012
PM 28043851
DA 2026-07-24
ER
PT J
AU Cooper, HJ
   Roc, GC
   Bas, MA
   Berliner, ZP
   Hepinstall, MS
   Rodriguez, JA
   Weiner, LS
AF Cooper, H. John
   Roc, Gilbert C.
   Bas, Marcel A.
   Berliner, Zachary P.
   Hepinstall, Matthew S.
   Rodriguez, Jose A.
   Weiner, Lon S.
TI Closed incision negative pressure therapy decreases complications after
   periprosthetic fracture surgery around the hip and knee
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Closed incision negative pressure therapy; Surgical site infections;
   Prevention; Periprosthetic fracture; Hip; Knee; Quality improvement
ID SURGICAL-SITE INFECTIONS; WOUND THERAPY; HIGH-RISK; FEMUR FRACTURES;
   UNITED-STATES; REVISION HIP; ARTHROPLASTY; PREVENTION; MORTALITY;
   MANAGEMENT
AB Introduction: Periprosthetic fractures (PPFXs) are becoming increasingly common following total hip arthroplasty (THA) and total knee arthroplasty (TKA). Patients sustaining PPFXs face considerable perioperative morbidity, with relatively increased rates of surgical site infection. We sought to evaluate the efficacy of closed-incision negative-pressure wound therapy (ciNPT) in decreasing perioperative wound complications following lower extremity periprosthetic fracture surgery.
   Methods: We performed a retrospective review of 69 consecutive patients who underwent surgery to address lower extremity periprosthetic fractures around hip or knee implants performed over a 6.5-year period. The population was divided into two groups based on the surgical dressing used at the conclusion of the procedure: (1) a sterile, antimicrobial hydrofiber dressing, or (2) ciNPT. There were no baseline demographic differences between the two groups. Rates of wound complications, surgical site infection, and reoperation related to the surgical site were compared between groups. Continuous variables were analyzed using a student's t-test, and categorical variables using either chi-square or fisher's exact test.
   Results: Patients treated with ciNPT developed fewer wound complications (4% vs. 35%; p = 0.002), fewer deep infections (0% vs. 25%; p = 0.004), and underwent fewer reoperations related to the surgical site (4% vs. 25%; p = 0.021) compared to patients treated with standard of care.
   Conclusions: Our findings suggest that ciNPT may reduce wound complications, SSIs, and reoperations in patients undergoing lower extremity periprosthetic fracture surgery. This is the first study to investigate ciNPT as a treatment for periprosthetic fracture surgery, and has the potential to change the postoperative management of these patients. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Cooper, H. John] Columbia Univ, Med Ctr, Dept Orthoped Surg, Div Hip & Knee Reconstruct, New York, NY USA.
   [Roc, Gilbert C.; Bas, Marcel A.; Berliner, Zachary P.; Hepinstall, Matthew S.] Northwell Hlth Syst, Lenox Hill Hosp, Dept Orthopaed Surg, Ctr Joint Preservat & Reconstruct, New York, NY USA.
   [Rodriguez, Jose A.] Hosp Special Surg, Dept Orthoped Surg, Adult Reconstruct & Joint Replacement Serv, 535 E 70th St, New York, NY 10021 USA.
   [Weiner, Lon S.] Northwell Hlth Syst, Lenox Hill Hosp, Dept Orthopaed Surg, Div Orthopaed Trauma, New York, NY USA.
C3 Columbia University; Northwell Health; Northwell Health
RP Cooper, HJ (通讯作者)，Columbia Univ, Med Ctr, Dept Orthoped Surg, 622 West 168th St,PH-11, New York, NY 10032 USA.
EM hjc2008@cumc.columbia.edu
RI Cooper, H./H-3488-2019; Hepinstall, Matthew/AAG-9271-2019
OI Hepinstall, Matthew/0000-0001-6002-8580
FU KCI
FX One of the authors (HJC) is a paid consultant for the manufacturer (KCI)
   of the device (Prevena) discussed in the manuscript. Multiple authors
   (HJC, MSH, JAR, LSW) have financial relationships (consultancy,
   royalties, speakers bureau, research support) from several implant
   companies, which are not relevant to the current manuscript. For the
   remaining authors, none were declared.
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NR 42
TC 44
Z9 48
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2018
VL 49
IS 2
BP 386
EP 391
DI 10.1016/j.injury.2017.11.010
PG 6
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA FX9TX
UT WOS:000426451500038
PM 29174454
OA hybrid
DA 2026-07-24
ER
PT J
AU Comellas, E
   Bellomo, FJ
   Rosales, I
   del Castillo, LF
   Sánchez, R
   Turon, P
   Oller, S
AF Comellas, Ester
   Bellomo, Facundo J.
   Rosales, Ivan
   del Castillo, Luis F.
   Sanchez, Ricardo
   Turon, Pau
   Oller, Sergio
TI On the feasibility of the computational modelling of the endoluminal
   vacuum-assisted closure of an oesophageal anastomotic leakage
SO ROYAL SOCIETY OPEN SCIENCE
LA English
DT Article
DE endoluminal vacuum-assisted closure; healing; growth; finite-element
   analysis; constitutive modelling
ID PRESSURE WOUND THERAPY; GASTROINTESTINAL ANASTOMOSES; MANAGEMENT;
   GROWTH; COMPLICATIONS; STRICTURES; SURGERY; STENT; STATE
AB Endoluminal vacuum-assisted closure (E-VAC) is a promising therapy to treat anastomotic leakages of the oesophagus and bowel which are associated with high morbidity and mortality rates. An open-pore polyurethane foam is introduced into the leakage cavity and connected to a device that applies a suction pressure to accelerate the closure of the defect. Computational analysis of this healing process can advance our understanding of the biomechanical mechanisms at play. To this aim, we use a dual-stage finite-element analysis in which (i) the structural problem addresses the cavity reduction caused by the suction and (ii) a new constitutive formulation models tissue healing via permanent deformations coupled to a stiffness increase. The numerical implementation in an in-house code is described and a qualitative example illustrates the basic characteristics of the model. The computational model successfully reproduces the generic closure of an anastomotic leakage cavity, supporting the hypothesis that suction pressure promotes healing by means of the aforementioned mechanisms. However, the current framework needs to be enriched with empirical data to help advance device designs and treatment guidelines. Nonetheless, this conceptual study confirms that computational analysis can reproduce E-VAC of anastomotic leakages and establishes the bases for better understanding the mechanobiology of anastomotic defect healing.
C1 [Comellas, Ester; Oller, Sergio] Int Ctr Numer Methods Engn CIMNE, Campus Nord,Bldg C1,C Gran Capita S-N, Barcelona 08034, Spain.
   [Bellomo, Facundo J.] Natl Univ Salta, Fac Engn, CONICET, INIQUI, Av Bolivia 5150, RA-4400 Salta, Argentina.
   [Rosales, Ivan; del Castillo, Luis F.; Sanchez, Ricardo; Turon, Pau] B Braun Surg SA, Carretera Terrassa 121, Barcelona 08191, Spain.
   [Oller, Sergio] Univ Politecn Cataluna, ETSECCPB, Dept Civil & Environm Engn, Barcelona Tech, Campus Nord,Bldg C1,C Jordi Girona 1-3, ES-08034 Barcelona, Spain.
   [Comellas, Ester] Univ Erlangen Nurnberg, Inst Appl Mech, Egerlandstr 5, D-91058 Erlangen, Germany.
C3 Universitat Politecnica de Catalunya; Centre Internacional de Metodes
   Numerics en Enginyeria (CIMNE); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Universitat Politecnica de Catalunya;
   University of Erlangen Nuremberg
RP Comellas, E (通讯作者)，Int Ctr Numer Methods Engn CIMNE, Campus Nord,Bldg C1,C Gran Capita S-N, Barcelona 08034, Spain.; Comellas, E (通讯作者)，Univ Erlangen Nurnberg, Inst Appl Mech, Egerlandstr 5, D-91058 Erlangen, Germany.
EM ester.comellas@fau.de
RI Oller, Sergio/M-2376-2014; Comellas, Ester/KCL-5139-2024
OI Oller, Sergio/0000-0002-5203-8903; Turon, Pau/0000-0001-6354-9701;
   Comellas, Ester/0000-0002-3981-2634
FU B. Braun Surgical, S.A.; Spanish 'Ministerio de Economia y Competividad'
   [BIA2015-67807-R-RESCICLO]
FX This work has been funded by B. Braun Surgical, S.A. S.O. acknowledges
   partial funding by the Spanish 'Ministerio de Economia y Competividad'
   through the project: BIA2015-67807-R-RESCICLO.
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NR 63
TC 3
Z9 3
U1 0
U2 5
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 2054-5703
J9 ROY SOC OPEN SCI
JI R. Soc. Open Sci.
PD FEB
PY 2018
VL 5
IS 2
AR 171289
DI 10.1098/rsos.171289
PG 23
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FX9YA
UT WOS:000426465700030
PM 29515846
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Brown, DJ
   Lu, KJG
   Chang, K
   Levin, J
   Schulz, JT
   Goverman, J
AF Brown, Darnell J.
   Lu, Kuo Jung G.
   Chang, Kristina
   Levin, Jennifer
   Schulz, John T., III
   Goverman, Jeremy
TI A rare case of severe third degree friction burns and large
   Morel-Lavallee lesion of the abdominal wall
SO BURNS & TRAUMA
LA English
DT Article
DE Friction burns; Blunt trauma friction burns; Internal degloving
   injuries; Morel-Lavallee lesion; Traumatic pseudocyst
ID MANAGEMENT; EXPERIENCE
AB Background: Morel-Lavallee lesions (MLLs) are rare internal degloving injuries typically caused by blunt traumatic injuries and most commonly occur around the hips and in association with pelvic or acetabular fractures. MLL is often overlooked in the setting of poly-trauma; therefore, clinicians must maintain a high degree of suspicion and be familiar with the management of such injuries, especially in obese poly-trauma patients.
   Case presentation: We present a 30-year-old female pedestrian struck by a motor vehicle who sustained multiple long bone fractures, a mesenteric hematoma, and full-thickness abdominal skin friction burn which masked a significant underlying abdominal MLL. The internal degloving caused significant devascularization of the overlying soft tissue and skin which required surgical drainage of hematoma, abdominal wall reconstruction with tangential excision, allografting, negative pressure wound therapy, and ultimately autografting.
   Conclusion: MLL is a rare, often overlooked, internal degloving injury. Surgeons must maintain a high index of suspicion when dealing with third degree friction burns as they may mask underlying injuries such as MLL, and a delay in diagnosis can lead to increased morbidity.
C1 [Brown, Darnell J.; Lu, Kuo Jung G.; Chang, Kristina; Levin, Jennifer; Schulz, John T., III; Goverman, Jeremy] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School
RP Brown, DJ (通讯作者)，Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA.
EM DJBrown85@MGH.Harvard.edu
RI Goverman, Jeremy/AAZ-6769-2020
CR Beckmann NM, 2016, EMERG RADIOL, V23, P615, DOI 10.1007/s10140-016-1430-1
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NR 14
TC 5
Z9 9
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2321-3868
EI 2321-3876
J9 BURNS TRAUMA
JI Burns Trauma
PD MAR 6
PY 2018
VL 6
AR 6
DI 10.1186/s41038-018-0108-1
PG 4
WC Emergency Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Dermatology; Surgery
GA FY3FU
UT WOS:000426704900001
PM 29556506
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mochizuki, T
   Ikari, K
   Hiroshima, R
   Takaoka, H
   Kawakami, K
   Koenuma, N
   Ishibashi, M
   Momohara, S
AF Mochizuki, Takeshi
   Ikari, Katsunori
   Hiroshima, Ryo
   Takaoka, Hiromitsu
   Kawakami, Kosei
   Koenuma, Naoko
   Ishibashi, Mina
   Momohara, Shigeki
TI Negative pressure wound therapy and skin grafting for necrotizing
   fasciitis in a patient with rheumatoid arthritis treated with abatacept:
   A case report
SO MODERN RHEUMATOLOGY
LA English
DT Article
DE Abatacept; Necrotizing fasciitis; Negative pressure wound therapy;
   Rheumatoid arthritis
ID INADEQUATE RESPONSE; LONG-TERM; TOCILIZUMAB; SAFETY; TRIAL
AB Herein, we present a case of necrotizing fasciitis (NF) in a patient with rheumatoid arthritis (RA) treated with abatacept. Cultures of the patient's leg effusion revealed group A Streptococcus. Treatment included antibiological drugs, repeat debridement, negative pressure wound therapy (NPWT), and skin grafting. This case highlights the need for suspicion of severe bacterial infection for early diagnosis and effective treatment. NF with RA can be treated effectively with repeat debridement and NPWT.
C1 [Mochizuki, Takeshi; Hiroshima, Ryo; Takaoka, Hiromitsu; Kawakami, Kosei; Koenuma, Naoko; Ishibashi, Mina] Kamagaya Gen Hosp, Dept Orthoped Surg, 929-6 Hatsutomi, Kamagaya, Chiba 2730121, Japan.
   [Ikari, Katsunori; Momohara, Shigeki] Tokyo Womens Med Univ, Inst Rheumatol, Tokyo, Japan.
C3 Tokyo Women's Medical University
RP Mochizuki, T (通讯作者)，Kamagaya Gen Hosp, Dept Orthoped Surg, 929-6 Hatsutomi, Kamagaya, Chiba 2730121, Japan.
EM twmutamo@gmail.com
FU AbbVie, Inc.; Asahi Kasei Pharma Corp.; Astellas Pharma Inc.;
   Bristol-Myers Squibb Co.; Chugai Pharmaceutical Co.; Eisai Co., Ltd.;
   Hisamitsu Pharmaceutical Co. Inc.; Janssen Pharmaceutical K. K.; Kaken
   Pharmaceutical Co. Ltd.; Mitsubishi Tanabe Pharma Co.; Santen
   Pharmaceutical Co., Ltd.; Taisho Toyama Pharmaceutical Co. Ltd.; Daiichi
   Sankyo Co., Ltd.; Nakashima Medical Co., Ltd.; Takeda Pharmaceutical
   Co., Ltd.
FX T. M. received honorarium for the lecture from AbbVie, Inc., Asahi Kasei
   Pharma Corp., Bristol-Myers Squibb Co., Chugai Pharmaceutical Co.,
   Daiichi Sankyo Co., Ltd., Eisai Co., Ltd., Eli Lilly Japan Co., Janssen
   Pharmaceutical K.K., Mitsubishi Tanabe Pharma Co., and Takeda
   Pharmaceutical Co., Ltd. K. Y. received honorarium for the lecture from
   Janssen Pharmaceutical K. K., Mitsubishi Tanabe Pharma Co., Santen
   Pharmaceutical Co., Ltd. and Takeda Pharmaceutical Co., Ltd. K. I.
   received honorarium for the lecture and/or unrestricted research grants
   from AbbVie, Inc., Asahi Kasei Pharma Corp., Astellas Pharma Inc.,
   Bristol-Myers Squibb Co., Chugai Pharmaceutical Co., Eisai Co., Ltd.
   Hisamitsu Pharmaceutical Co. Inc., Janssen Pharmaceutical K. K., Kaken
   Pharmaceutical Co. Ltd., Mitsubishi Tanabe Pharma Co., Santen
   Pharmaceutical Co., Ltd., Taisho Toyama Pharmaceutical Co. Ltd. and
   Takeda Pharmaceutical Co., Ltd. S. M. received honorarium for the
   lecture and/or unrestricted research grants from AbbVie, Inc., Asahi
   Kasei Pharma Corp., Bristol-Myers Squibb Co., Chugai Pharmaceutical Co.,
   Daiichi Sankyo Co., Ltd., Eisai Co., Ltd., Mitsubishi Tanabe Pharma Co.,
   Nakashima Medical Co., Ltd., Santen Pharmaceutical Co., Ltd., Taisho
   Toyama Pharmaceutical Co. Ltd. and Takeda Pharmaceutical Co., Ltd. The
   other authors declare that they have no conflicts of interest.
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NR 15
TC 0
Z9 1
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1439-7595
EI 1439-7609
J9 MOD RHEUMATOL
JI Mod. Rheumatol.
PY 2018
VL 28
IS 2
BP 358
EP 360
DI 10.3109/14397595.2015.1106645
PG 3
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA FY6FG
UT WOS:000426937600023
PM 26457807
DA 2026-07-24
ER
PT J
AU Jeffery, S
   Leaper, D
   Armstrong, D
   Lantis, J
AF Jeffery, Steven
   Leaper, David
   Armstrong, David
   Lantis, John
TI Using negative pressure wound therapy to prevent surgical site infection
SO JOURNAL OF WOUND CARE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; INCISION MANAGEMENT; RISK-FACTORS; MULTICENTER;
   DEHISCENCE; PREDICTORS; MORTALITY; DRESSINGS; IMPROVES; IMPACT
AB It is estimated that, at the very least, 5% of patients who undergo surgery develop a surgical site infection (SSI). There has been much interest in the use of negative pressure wound therapy (NPWT) as a prophylactic treatment to reduce the risk of SSI. Evidence suggests it can accelerate healing times, reduce both the length of hospital stay and the frequency of dressing changes, and improve patients' quality of life. The efficacy of traditional and portable NPWT systems is similar. However, the latter has an advantage in that it increases patient mobility and does not hinder individuals from carrying out activities of daily living. There are also economic data suggesting that portable NPWT devices are associated with long-term cost savings
C1 [Jeffery, Steven] Birmingham City Univ, Wound Study, Birmingham, W Midlands, England.
   [Leaper, David] Newcastle Univ, Surg, Newcastle Upon Tyne, Tyne & Wear, England.
   [Leaper, David] Univ Huddersfield, Clin Sci, Huddersfield, W Yorkshire, England.
   [Armstrong, David] Univ Southern Calif, Keck Sch Med, Surg, Los Angeles, CA 90089 USA.
   [Armstrong, David] Univ Southern Calif, Keck Sch Med, SALSA, Los Angeles, CA 90089 USA.
   [Lantis, John] Mt Sinai St Lukes & West Hosp, Dept Surg, Mountain View, CA USA.
   [Lantis, John] Mt Sinai St Lukes & West Hosp, Vasc & Endovasc Surg, Mountain View, CA USA.
   [Lantis, John] Icahn Sch Med, Surg, New York, NY USA.
C3 Birmingham City University; Newcastle University - UK; University of
   Huddersfield; University of Southern California; University of Southern
   California; Icahn School of Medicine at Mount Sinai
RP Jeffery, S (通讯作者)，Birmingham City Univ, Wound Study, Birmingham, W Midlands, England.
RI jeffery, steven/A-5207-2013
OI jeffery, steven/0000-0001-6587-5412
CR [Anonymous], 2016, Global Guidelines for the Prevention of Surgical Site Infection
   [Anonymous], 2019, Overview. Surgical Site Infections: Prevention and Treatment | Guidance | NICE
   [Anonymous], 2016, SURV SURG SIT INF NH
   [Anonymous], 2012, WOUNDS K
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   World Union of Wound Healing Societies, 2016, Consensus document. Closed surgical incision management: understanding the role of NPWT
NR 87
TC 11
Z9 13
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2018
VL 27
IS 3
SU 3
BP S5
EP S13
DI 10.12968/jowc.2018.27.Sup3.S5
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FY6QY
UT WOS:000426981900002
PM 29509094
DA 2026-07-24
ER
PT J
AU Go, ML
   Vallarino, N
   Devriendt, N
   Van Goethem, B
   Polis, I
   Stock, E
   de Rooster, H
AF Go, M. L.
   Vallarino, N.
   Devriendt, N.
   Van Goethem, B.
   Polis, I.
   Stock, E.
   de Rooster, H.
TI Closed incision management with negative pressure wound therapy after
   forelimb amputation in a dog
SO VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS; COMPLICATIONS; VARIABLES; SURGERY;
   FOAM
AB A four-year-old male castrated German shepherd dog was presented with severe left front leg lameness due to a fibrosarcoma lateral to the elbow. The ill-defined mass was not amendable to wide local excision and a curative-intent limb amputation was performed. Immediately postoperatively, closed incision management with negative pressure wound therapy (NPWT) was applied to minimize the risk of postoperative complications. The incision line was covered with a Prevena (TM) dressing attached to a NPWT pump set at a continuous negative pressure of -125 mmHg. The dressing was removed 72 hours later. No wound complications were evident and further healing was unremarkable.
C1 [Go, M. L.; Vallarino, N.; Devriendt, N.; Van Goethem, B.; Polis, I.; de Rooster, H.] Univ Ghent, Fac Vet, Small Anim Dept, Salisburylaan 133, B-9820 Merelbeke, Belgium.
   [Stock, E.] Univ Ghent, Fac Vet, Dept Med Imaging Domest Animals & Orthoped Small, Salisburylaan 133, B-9820 Merelbeke, Belgium.
C3 Ghent University; Ghent University
RP de Rooster, H (通讯作者)，Univ Ghent, Fac Vet, Small Anim Dept, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM hilde.derooster@ugent.be
RI Devriendt, Nausikaa/S-6629-2019; de Rooster, Hilde/AAX-9497-2020; Van
   Goethem, Bart/AAM-7175-2020
OI Devriendt, Nausikaa/0000-0002-5070-8176; de Rooster,
   Hilde/0000-0001-8087-256X; 
CR Amsellem P, 2011, VET CLIN N AM-SMALL, V41, P995, DOI 10.1016/j.cvsm.2011.05.005
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NR 35
TC 0
Z9 0
U1 0
U2 9
PU UNIV GHENT
PI GHENT
PA FACULTY VETERINARY MEDICINE, B-9000 GHENT, BELGIUM
SN 0303-9021
J9 VLAAMS DIERGEN TIJDS
JI Vlaams Diergeneeskd. Tijdschr.
PD JAN-FEB
PY 2018
VL 87
IS 1
BP 30
EP 36
DI 10.21825/vdt.v87i1.16093
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FY8HU
UT WOS:000427105800004
OA Bronze
DA 2026-07-24
ER
PT J
AU Bludau, M
   Fuchs, HF
   Herbold, T
   Maus, MKH
   Alakus, H
   Popp, F
   Leers, JM
   Bruns, CJ
   Hölscher, AH
   Schröder, W
   Chon, SH
AF Bludau, Marc
   Fuchs, Hans F.
   Herbold, Till
   Maus, Martin K. H.
   Alakus, Hakan
   Popp, Felix
   Leers, Jessica M.
   Bruns, Christiane J.
   Hoelscher, Arnulf H.
   Schroeder, Wolfgang
   Chon, Seung-Hun
TI Results of endoscopic vacuum-assisted closure device for treatment of
   upper GI leaks
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   Society-of-American-Gastrointestinal-and-Endoscopic-Surgeons (SAGES)
CY MAR 22-25, 2017
CL Houston, TX
SP Soc Amer Gastrointestinal & Endoscop Surg
DE Esophageal perforation; Anastomotic leakage; Endoscopic vacuum-assisted
   closure system
ID ESOPHAGEAL-PERFORATION; RETROSPECTIVE ANALYSIS; ANASTOMOTIC LEAKAGE;
   TREATMENT OPTIONS; THERAPY; MANAGEMENT; STENT
AB Esophageal perforations and postoperative leakage of esophagogastrostomies are considered to be life-threatening conditions due to the potential development of mediastinitis and consecutive sepsis. Vacuum-assisted closure (VAC) techniques, a well-established treatment method for superficial infected wounds, are based on a negative pressure applied to the wound via a vacuum-sealed sponge. Endoluminal VAC (E-VAC) therapy as a treatment for GI leakages in the rectum was introduced in 2008. E-VAC therapy is a novel method, and experience regarding esophageal applications is limited. In this retrospective study, the experience of a high-volume center for upper GI surgery with E-VAC therapy in patients with leaks of the upper GI tract is summarized. To our knowledge, this series presents the largest patient cohort worldwide in a single-center study.
   Between October 2010 and January 2017, 77 patients with defects in the upper gastrointestinal tract were treated using the E-VAC application. Six patients had a spontaneous perforation, 12 patients an iatrogenic injury, and 59 patients a postoperative leakage in the upper gastrointestinal tract.
   Complete restoration of the esophageal defect was achieved in 60 of 77 patients. The average duration of application was 11.0 days, and a median of 2.75 E-VAC systems were used. For 21 of the 77 patients, E-VAC therapy was combined with the placement of self-expanding metal stents.
   This study demonstrates that E-VAC therapy provides an additional treatment option for esophageal wall defects. Esophageal defects and mediastinal abscesses can be treated with E-VAC therapy where endoscopic stenting may not be possible. A prospective multi-center study has to be directed to bring evidence to the superiority of E-VAC therapy for patients suffering from upper GI defects.
C1 [Bludau, Marc; Fuchs, Hans F.; Maus, Martin K. H.; Alakus, Hakan; Popp, Felix; Leers, Jessica M.; Bruns, Christiane J.; Schroeder, Wolfgang; Chon, Seung-Hun] Univ Cologne, Dept Gen Visceral & Canc Surg, Kerpener Str 62, D-50937 Cologne, Germany.
   [Herbold, Till] Rhein Westfal TH Aachen, Dept Gen Visceral & Canc Surg, Aachen, Germany.
   [Hoelscher, Arnulf H.] Agaples Markus Hosp, Dept Gen Thorac & Vasc Surg, Frankfurt, Germany.
C3 University of Cologne; RWTH Aachen University
RP Bludau, M (通讯作者)，Univ Cologne, Dept Gen Visceral & Canc Surg, Kerpener Str 62, D-50937 Cologne, Germany.
EM Marc.Bludau@uk-koeln.de
RI Chon, Seung-Hun/PHE-1824-2026; Schröder, Wolfgang/A-8799-2008;
   /AAP-2598-2021
OI Bludau, Marc/0000-0002-0338-1545; Chon, Seung-Hun/0000-0002-8923-6428
CR Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Hwang JJ, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003416
   Kuehn F, 2017, SURG ENDOSC, V31, P3449, DOI 10.1007/s00464-016-5404-x
   Laukoetter MG, 2017, SURG ENDOSC, V31, P2687, DOI 10.1007/s00464-016-5265-3
   Leers JM, 2009, SURG ENDOSC, V23, P2258, DOI 10.1007/s00464-008-0302-5
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   Schorsch T, 2014, CHIRURG, V85, P1081, DOI 10.1007/s00104-014-2764-4
   Schröder W, 2014, CHIRURG, V85, P1064, DOI 10.1007/s00104-014-2805-z
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NR 20
TC 108
Z9 123
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD APR
PY 2018
VL 32
IS 4
BP 1906
EP 1914
DI 10.1007/s00464-017-5883-4
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA FY9BD
UT WOS:000427159300035
PM 29218673
DA 2026-07-24
ER
PT J
AU Andersson, S
   Monsen, C
   Acosta, S
AF Andersson, Sebastian
   Monsen, Christina
   Acosta, Stefan
TI Outcome and Complications Using Negative Pressure Wound Therapy in the
   Groin for Perivascular Surgical Site Infections after Vascular Surgery
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID GRAFT INFECTION; PREVENTION; CLOSURE; MICROBIOLOGY; MANAGEMENT
AB Background: The aim of this study was to investigate graft preservation, major bleeding, and reinfection rate using negative pressure wound therapy (NPWT) for perivascular surgical site infections (SSIs) in the groin after vascular surgery and factors associated with failure of treatment.
   Methods: Retrospective data were collected during 2004-2015. Failure of wound treatment was defined as a wound not healed within 4 months, visible graft material or native artery after 1 month, bleeding from the wound leading to discontinuation of treatment, or death or amputation due to the groin infection.
   Results: The median age of the 161 patients was 71 years; 63% were men. The rate of graft preservation rate was 81%; 64% for synthetic grafts. Major bleeding during NPWT occurred in 7.1% and local reinfection in 6.4%. Synthetic graft infection (odds ratio [OR] = 6.1, 95% confidence interval [CI] = 2.6-14.4) and bleeding/pseudoaneurysm as presenting symptom (OR = 2.9, 95% CI = 1.0-8.2) were independently associated with increased failure rate of treatment.
   Conclusions: NPWT is a good option for perivascular SSI in the groin after vascular surgery. Patients with a synthetic graft infection and/or presenting with pseudoaneurysm or bleeding may be considered for an adjunctive or alternative treatment option.
C1 [Andersson, Sebastian; Monsen, Christina; Acosta, Stefan] Lund Univ, Dept Clin Sci, Malmo, Sweden.
   [Andersson, Sebastian; Monsen, Christina; Acosta, Stefan] Skane Univ Hosp, Dept Cardiothorac & Vasc Surg, Vasc Ctr, Malmo, Sweden.
C3 Lund University; Lund University; Skane University Hospital
RP Acosta, S (通讯作者)，Lund Univ, Dept Clin Sci, Vasc Surg, Ruth Lundskogsg 10, S-20502 Malmo, Sweden.
EM stefan.acosta@med.lu.se
RI Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
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   Cheng HT, 2014, INTERACT CARDIOV TH, V19, P1048, DOI 10.1093/icvts/ivu289
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   Dumville JC, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011278.pub2
   Gao H, 2010, EUR J VASC ENDOVASC, V39, P472, DOI 10.1016/j.ejvs.2009.11.023
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   Illig KA, 2004, ANN VASC SURG, V18, P661, DOI 10.1007/s10016-004-0105-7
   Inui T, 2015, SEMIN VASC SURG, V28, P201, DOI 10.1053/j.semvascsurg.2016.02.002
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   Monsen C, 2014, J VASC SURG, V59, P145, DOI 10.1016/j.jvs.2013.06.073
   Powers ME, 2014, PLOS PATHOG, V10, DOI 10.1371/journal.ppat.1003871
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   SZILAGYI DE, 1972, ANN SURG, V176, P321, DOI 10.1097/00000658-197209000-00008
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   Yang C, 2017, WOUNDS, V29, P240
NR 21
TC 10
Z9 13
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD APR
PY 2018
VL 48
BP 104
EP 110
DI 10.1016/j.avsg.2017.10.018
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA FZ4PR
UT WOS:000427574700010
PM 29217444
DA 2026-07-24
ER
PT J
AU Saijo, H
   Kilpadi, DV
   Akita, S
AF Saijo, Hiroto
   Kilpadi, Deepak V.
   Akita, Sadanori
TI Evaluation of the use of recombinant human basic fibroblast growth
   factor in combination with negative pressure wound therapy with
   instillation and dwell time in porcine full-thickness wound model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID AUTOLOGOUS BONE-MARROW; SALINE INSTILLATION; CELLS
AB NPWT with instillation and dwell time (NPWTi-d), which combines NPWT with wound irrigation, has been clinically applied as a more effective treatment than conventional NPWT. Commercially available recombinant human basic fibroblast growth factor (rh-bFGF) has been demonstrated to be beneficial for use over the wound beds. The objective of this study was to evaluate the effectiveness of combined treatment with NPWTi-d and rh-bFGF. Six pigs received 12 full-thickness excisional skin wounds and were treated with six different treatment groups for each pair. The treatment regimens were composed NPWTi-d, NPWT, or advanced wound care with or without rh-bFGF. On day 6, the minimum granulation tissue thickness and blood vessel number of the group of combined treatment with NPWTi-d and rh-bFGF spray were significantly greater than that of the control group. Combined treatment with NPWTi-d and rh-bFGF spray reads to good granulation tissue formation and vascularization for accelerating wound healing.
C1 [Saijo, Hiroto] Nagasaki Univ, Dept Plast & Reconstruct Surg, Grad Sch Biomed Sci, Nagasaki, Japan.
   [Kilpadi, Deepak V.] Kinet Concepts Inc, Act Healing Solut Appl Sci, San Antonio, TX USA.
   [Akita, Sadanori] Fukuoka Univ, Sch Med, Dept Plast Surg Wound Repair & Regenerat, Fukuoka, Japan.
C3 Nagasaki University; Fukuoka University
RP Akita, S (通讯作者)，Fukuoka Univ, Sch Med, Dept Plast Surg Wound Repair & Regenerat, Jonan Ku, 7-45-1 Nanakuma, Fukuoka 8140180, Japan.
EM akitas@fukuoka-u.ac.jp
RI Saijo, Hiroto/AAC-4030-2020; akita, sadanori/Y-6838-2019
OI Saijo, Hiroto/0000-0003-3646-0263; akita, sadanori/0000-0001-8225-9363
FU KCI
FX This study was supported by KCI. Dr. Kilpadi is employed by KCI, H27-10.
CR Akela A, 2012, INT WOUND J, V9, P505, DOI 10.1111/j.1742-481X.2011.00909.x
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   Galili U, 2015, J IMMUNOL RES, V2015, DOI 10.1155/2015/589648
   Gupta S, 2016, INT WOUND J, V13, P159, DOI 10.1111/iwj.12452
   Hamuy R, 2013, WOUND REPAIR REGEN, V21, P141, DOI 10.1111/j.1524-475X.2012.00864.x
   Hurwitz ZM, 2012, PLAST RECONSTR SURG, V129, p242E, DOI 10.1097/PRS.0b013e31823aebb1
   Kanda Y, 2013, BONE MARROW TRANSPL, V48, P452, DOI 10.1038/bmt.2012.244
   Lessing C, 2011, WOUNDS, V23, P309
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NR 15
TC 6
Z9 6
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2017
VL 25
IS 6
BP 972
EP 975
DI 10.1111/wrr.12609
PG 4
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA FZ4ZY
UT WOS:000427602100007
PM 29328528
DA 2026-07-24
ER
PT J
AU Poehnert, D
   Hadeler, N
   Schrem, H
   Kaltenborn, A
   Klempnauer, J
   Winny, M
AF Poehnert, Daniel
   Hadeler, Nils
   Schrem, Harald
   Kaltenborn, Alexander
   Klempnauer, Juergen
   Winny, Markus
TI Decreased superficial surgical site infections, shortened hospital stay,
   and improved quality of life due to incisional negative pressure wound
   therapy after reversal of double loop ileostomy
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE;
   HEALTH-CARE-SYSTEM; HIGH-RISK; PREVENTION; IMPACT; METAANALYSIS;
   LAPAROTOMY; COSTS
AB This single-center prospective, controlled observational study investigates the impact of incisional negative pressure wound therapy on wound healing processes and its potency to prevent superficial surgical site infections (SSSI) after reversal of a double loop ileostomy. Furthermore, this study gains insight in socioeconomic aspects, like duration of hospital stay and, for the first time, patient's quality of life during the incisional negative pressure wound treatment. To address this question, an interventional group of 24 patients treated with incisional negative pressure wound therapy (Prevena incisional wound management system, KCI, Germany) and a respective control cohort of 25 patients treated with a standard sterile dressing were observed for 30 days in the postoperative course. Postoperative incisional negative pressure wound therapy resulted in statistically significant decreasing duration of hospital stay (6 days vs. 9 days, p=0.019) and lower rates of SSSIs (12.5% vs. 20.0%, p=0.478) in accordance with a not statistically significant decreased necessity of postoperative antibiotic therapy (12.5% vs. 36%, p=0.051). To survey subjective items of well-being and quality of life, all patients were asked to answer a questionnaire. Patients of both groups noticed increasing quality of life after reversal of their ileostomy. However, patients treated with an incisional negative pressure wound therapy had a superior improvement of a variety of subjective items, resulting in an overall much better satisfaction with the course of wound healing. Our findings suggest, that incisional negative pressure wound therapy seems to be a reasonable therapeutic option to reduce incidence of SSSIs and to have a beneficial impact to patient's quality of life, as well as, socio-economic aspects.
C1 [Poehnert, Daniel; Hadeler, Nils; Schrem, Harald; Klempnauer, Juergen; Winny, Markus] Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [Schrem, Harald; Kaltenborn, Alexander] Hannover Med Sch, Core Facil Qual Management Transplantat, Integrated Res & Treatment Ctr Transplantat IFB T, Hannover, Germany.
   [Kaltenborn, Alexander] Fed Armed Forces Hosp Westerstede, Dept Trauma & Orthopaed Surg, Westerstede, Germany.
C3 Hannover Medical School; Hannover Medical School
RP Poehnert, D (通讯作者)，Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM poehnert.daniel@mh-hannover.de
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NR 27
TC 20
Z9 26
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2017
VL 25
IS 6
BP 994
EP 1001
DI 10.1111/wrr.12606
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA FZ4ZY
UT WOS:000427602100010
PM 29356190
OA Bronze
DA 2026-07-24
ER
PT J
AU Cekici, SG
   Ulukent, SC
   Yildirim, GY
   Esmer, AC
   Akca, A
   Kublay, A
AF Cekici, S. Guler
   Ulukent, S. C.
   Yildirim, G. Yetkin
   Esmer, A. Corbacioglu
   Akca, A.
   Kublay, A.
TI A case of spontaneous bladder rupture following vaginal delivery in a
   mutilated woman
SO CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
LA English
DT Article
DE Female genital mutilation; Genitourinary system injuries; Spontaneous
   bladder rupture
AB Background: Female genital mutilation/cutting (FGM/C) is applied to more than 130 million women in the world with long-term complications of pain, dyspareunia, difficulty in urination, recurrent urinary tract infection, vesicovaginal fistula, and obstetric morbidities. The authors present a case of spontaneous bladder rupture following vaginal delivery in a genital mutilated pregnant woman, which has not been reported in the literature previously. Case Report: A 31-year old age primigravid woman presented on postpartum 6th day with abdominal distention, ileus, dyspnea, and acute renal failure. After physical and radiological examination with laboratory analysis the initial diagnosis was intra-abdominal sepsis. During laparotomy, disseminated abscess formation and massive urinary leakage from ruptured bladder wall was observed. After bladder repair, open abdomen procedure was performed to control abdominal infection. Vacuum-assisted closure therapy was applied as a temporary abdominal closure method. The patient was discharged from the hospital with no complications on the 14th day. Conclusion: This case report shows that genital mutilation can lead to genitourinary system injuries and is one of the etiologic factors of spontaneous bladder rupture during vaginal delivery.
C1 [Cekici, S. Guler; Yildirim, G. Yetkin; Akca, A.] Kanuni Sultan Suleyman Training & Res Hosp, Dept Obstet & Gynecol, Turgut Ozal Cad 1, TR-34303 Istanbul, Turkey.
   [Ulukent, S. C.] Kanuni Sultan Suleyman Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Esmer, A. Corbacioglu] Kanuni Sultan Suleyman Training & Res Hosp, Dept Maternal Fetal Med, Istanbul, Turkey.
   [Kublay, A.] Kanuni Sultan Suleyman Training & Res Hosp, Dept Gyneccol Oncol, Istanbul, Turkey.
C3 Istanbul Kanuni Sultan Suleyman Training & Research Hospital; Istanbul
   Kanuni Sultan Suleyman Training & Research Hospital; Istanbul Kanuni
   Sultan Suleyman Training & Research Hospital; Istanbul Kanuni Sultan
   Suleyman Training & Research Hospital
RP Cekici, SG (通讯作者)，Kanuni Sultan Suleyman Training & Res Hosp, Dept Obstet & Gynecol, Turgut Ozal Cad 1, TR-34303 Istanbul, Turkey.
EM sebileguler@gmail.com
RI ULUKENT, SUAT CAN/A-7012-2018; Güler Çekiç, Sebile/KGM-4777-2024
OI ULUKENT, SUAT CAN/0000-0002-1714-847X; Güler Çekiç,
   Sebile/0000-0002-1632-1170
CR Banks E, 2006, LANCET, V367, P1835, DOI 10.1016/S0140-6736(06)68805-3
   Berg RC, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-006316
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   Png KS, 2008, SINGAP MED J, V49, pE327
   Wandabwa Julius, 2004, Afr Health Sci, V4, P138
NR 8
TC 1
Z9 1
U1 0
U2 2
PU I R O G CANADA, INC
PI MONTREAL
PA 4900 COTE ST-LUC, APT#212, MONTREAL, QUEBEC H3W 2H3, CANADA
SN 0390-6663
J9 CLIN EXP OBSTET GYN
JI Clin. Exp. Obstet. Gynecol.
PY 2017
VL 44
IS 6
BP 941
EP 943
DI 10.12891/eeog3791.2017
PG 3
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FZ5AQ
UT WOS:000427604100025
DA 2026-07-24
ER
PT J
AU Canavese, F
   Marengo, L
   Corradin, M
   Mansour, M
   Samba, A
   Andreacchio, A
   Rousset, M
   Dimeglio, A
AF Canavese, Federico
   Marengo, Lorenza
   Corradin, Marco
   Mansour, Mounira
   Samba, Antoine
   Andreacchio, Antonio
   Rousset, Marie
   Dimeglio, Alain
TI Deep postoperative spine infection treated by negative pressure therapy
   in patients with progressive spinal deformities
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE Deep spine infection; Children; Adolescents; Sublaminar bands; Hybrid
ID VACUUM-ASSISTED CLOSURE; NEUROMUSCULAR SCOLIOSIS; SURGERY; FUSION;
   INSTRUMENTATION; EXPERIENCE; MANAGEMENT; WOUNDS
AB The aim of the study is to review the outcome of using the VAC system in children and adolescents who have developed postoperative spinal infection after posterior instrumented spinal fusion, and to evaluate whether this technique is also feasible in patients treated with posterior instrumented fusion with polyester sublaminar bands.
   A total of 11 out of 118 consecutive children and adolescents (5 males) with deep postoperative spinal infection were identified; infections were categorised as early (acute), delayed (subacute) or late (chronic) according to time of onset. Irrespective of the etiology and the onset, all the deep infections were managed with the reported technique. All the patients had regular clinical and radiological follow-up.
   Eight out of 11 patients developed an early (72.7%), 2 a delayed (18.2%) and 1 a late deep postoperative infection (9.1%); 7 out of 11 (63.6%) showed severe mental compromise. No statistically significant differences were observed for mean number of VAC dressing changes (p = 0.81) and mean length of hospitalisation comparing patients with early infection versus patients with delayed or late infections (p = 0.32). Mean number of VAC dressing changes (p = 0.02) and mean number of hospitalisation days (p = 0.05) were higher in patients with underlying neurological disorders than in those without, while mean length of hospitalisation was longer in neuromuscular patients.
   The application of the VAC system, as an adjunct to surgical debridement and adequate antibiotic therapy, is a reliable method for the treatment of postoperative infection in children and adolescents undergoing spinal instrumentation and fusion. It can reduce the need for further complex soft-tissue procedure, removal of hardware with consequent loss of correction, and pseudoarthrosis. Finally, the use of VAC therapy is not contraindicated in patients treated with hybrid constructs with sublaminar bands.
   III.
C1 [Canavese, Federico; Marengo, Lorenza; Corradin, Marco; Mansour, Mounira; Samba, Antoine; Rousset, Marie] Univ Hosp Estaing, Dept Pediat Surg, 1 Pl Lucie & Raymond Aubrac, F-63003 Clermont Ferrand, France.
   [Andreacchio, Antonio] Regina Margherita Children Hosp, Pediat Orthopaed Dept, Piazza Polonia 94, I-10126 Turin, Italy.
   [Dimeglio, Alain] Clin St Roch, Dept Orthoped Surg, Bat B 550 Ave Colonel Andre Pavelet, F-34070 Montpellier, France.
C3 Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; A.O.U. Citta
   della Salute e della Scienza di Torino; Universite de Montpellier
RP Canavese, F (通讯作者)，Univ Hosp Estaing, Dept Pediat Surg, 1 Pl Lucie & Raymond Aubrac, F-63003 Clermont Ferrand, France.
EM canavese_federico@yahoo.fr
RI Marengo, Lorenza/AAB-8689-2021; Andreacchio, Antonio/I-1421-2019
OI Marengo, Lorenza/0000-0003-2236-6866; CANAVESE,
   Federico/0000-0002-6114-5372; Andreacchio, Antonio/0000-0001-7729-3890
CR Aceves Pérez Alberto, 2013, Coluna/Columna, V12, P330
   Aleissa S, 2011, CAN J SURG, V54, P263, DOI 10.1503/cjs.008210
   [Anonymous], ANN R COLL SURG ENGL, V95, P118
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Cahill PJ, 2010, SPINE, V35, P1211, DOI 10.1097/BRS.0b013e3181c212d1
   Canavese F, 2008, J BONE JOINT SURG BR, V90B, P377, DOI 10.1302/0301-620X.90B3.19890
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NR 22
TC 14
Z9 16
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD APR
PY 2018
VL 138
IS 4
BP 463
EP 469
DI 10.1007/s00402-017-2860-2
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA FZ5IO
UT WOS:000427625900004
PM 29270822
DA 2026-07-24
ER
PT J
AU Zhang, XX
   Wan, L
   Yang, RJ
   Jin, PP
   Xia, WD
   Ye, YY
   Liu, ZJ
   Xian, J
   Li, X
   Cheng, XB
   Lin, C
AF Zhang, Xingxing
   Wan, Li
   Yang, Ruijin
   Jin, Pengpeng
   Xia, Weidong
   Ye, Yuanyuan
   Liu, Zhengjun
   Xian, Jian
   Li, Xu
   Cheng, Xingbo
   Lin, Cai
TI Expression of connective tissue growth factor and periostin of wound
   tissue in patients with diabetes who had vacuum sealing drainage
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Diabetic ulcer; connective tissue growth factor; periostin; vacuum
   sealing drainage
ID ASSISTED CLOSURE; CCN2 EXPRESSION
AB This study aimed to examine clinical effect of vacuum sealing drainage in treating the wound tissue of patients with diabetes; and investigate the expression of periostin and connective tissue growth factor in wound tissue. We selected 40 patients with diabetes and chronic ulcers, and assigned randomly into two groups: the vacuum sealing drainage group and routine dressing group (controls). Tissues were cut at day 1 before treatment and day 7 after treatment. Immunohistochemistry was used to observe periostin and connective tissue growth factor expression. Cure time and cure rate between the two groups was observed. Connective tissue growth factor and periostin were rarely expressed in wound tissue before treatment, but were increased after treatment. The mean count of periostin-positive cells was 25.2 +/- 3.50 in the vacuum sealing drainage group and 12.9 +/- 1.8 in the control group (P < 0.05). The mean count of connective tissue growth factor-positive cells was 19.7 +/- 2.54 in the vacuum sealing drainage group and 6.8 +/- 1.58 in the control group (P < 0.05). The mean duration of hospitalization of the vacuum sealing drainage group was 33.4 +/- 7.91 days, and 17 (85%) patients were cured. The mean duration of hospitalization of the routine treatment group was 50.45 +/- 6.77 days, and 13 (65%) patients were cured (both P < 0.05). This study shows that vacuum sealing drainage can shorten the healing time of diabetic chronic wounds and was addition to the mechanism of the vacuum sealing drainage treatment of diabetic wound.
C1 [Zhang, Xingxing; Cheng, Xingbo] Soochow Univ, Affiliated Hosp 1, Dept Endocrinol, Suzhou 215006, Peoples R China.
   [Wan, Li] Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou 325000, Zhejiang, Peoples R China.
   [Xia, Weidong; Ye, Yuanyuan; Liu, Zhengjun; Lin, Cai] Wenzhou Med Univ, Affiliated Hosp 1, Dept Burn & Wound Healing Ctr, Wenzhou 325000, Zhejiang, Peoples R China.
   [Jin, Pengpeng] Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Ctr Med Res & Innovat, 2800 Gongwei Rd, Shanghai 201399, Peoples R China.
   [Xian, Jian] Wenzhou Med Univ, Key Lab Biotechnol & Pharmaceut Engn, Sch Pharm, Wenzhou 325000, Zhejiang, Peoples R China.
   [Li, Xu] Wenzhou Med Univ, Dept Physiol, Renji Coll, Wenzhou 325000, Zhejiang, Peoples R China.
   [Yang, Ruijin] Sun Yat Sen Univ, Tung Wah Hosp, Dept Burns & Plast Surg, Dongguan 523000, Guangdong, Peoples R China.
   [Zhang, Xingxing] Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Soochow University - China; Wenzhou Medical University; Wenzhou Medical
   University; Fudan University; Wenzhou Medical University; Wenzhou
   Medical University; Sun Yat Sen University; Wenzhou Medical University
RP Cheng, XB (通讯作者)，Soochow Univ, Affiliated Hosp 1, Dept Endocrinol, Suzhou 215006, Peoples R China.; Lin, C (通讯作者)，Wenzhou Med Univ, Affiliated Hosp 1, Dept Burn & Wound Healing Ctr, Wenzhou 325000, Zhejiang, Peoples R China.
EM Xingbo1107@sohu.com; lincai_0577@163.com
RI Xian, Jianzhong/HCI-4011-2022
FU Action Planning for Major disease prevention science and technology of
   Development Center for Medical Science and Technology National Health
   and Family Planning Commission of the People's Republic of China
   [ZX-01-C2015041]; Science and Technology Program of Wenzhou [Y20150273,
   Y20130166, Y20140-187]; Education Department of Zhejiang Province
   [Y201431185]
FX This work was supported by The Action Planning for Major disease
   prevention science and technology of Development Center for Medical
   Science and Technology National Health and Family Planning Commission of
   the People's Republic of China (ZX-01-C2015041, Science and Technology
   Program of Wenzhou (Grant No. Y20150273, Y20130166, and Y20140-187), and
   Education Department of Zhejiang Province (No. Y201431185).
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NR 24
TC 6
Z9 6
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 8
BP 12942
EP 12950
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FZ6PT
UT WOS:000427722200001
DA 2026-07-24
ER
PT J
AU Rottoli, M
   Di Simone, MP
   Vallicelli, C
   Vittori, L
   Liguori, G
   Boschi, L
   Poggioli, G
AF Rottoli, M.
   Di Simone, M. P.
   Vallicelli, C.
   Vittori, L.
   Liguori, G.
   Boschi, L.
   Poggioli, G.
TI Endoluminal vacuum-assisted therapy as treatment for anastomotic leak
   after ileal pouch-anal anastomosis: a pilot study
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE Proctocolectomy, Restorative; Anastomosis, Surgical; Postoperative
   complications; Endosponge; Negative-pressure wound therapy
ID PROCTOCOLECTOMY; COMPLICATIONS; METAANALYSIS
AB Anastomotic leak after ileal pouch-anal anastomosis (IPAA) could lead to poor functional results and failure of the pouch. The aim of the present study was to analyze the outcomes of the vacuum-assisted closure therapy as the unique treatment for anastomotic leaks following IPAA without any additional surgical operations.
   Consecutive patients with anastomotic leak after IPAA treated at our institution between March 2016 and March 2017 were prospectively enrolled. After diagnosis, the Endosponge(A (R)) device was positioned in the gap and replaced until the cavity was reduced in size and covered by granulating tissue. A pouchoscopy was performed every week for the first month and monthly subsequently. No additional procedures were performed.
   Eight patients were included in the study. The leak was diagnosed at a median of 14 (6-35) days after surgery. At the time of diagnosis, seven patients had a defunctioning ileostomy performed as routine at the time of pouch formation, while one patient was diagnosed after ileostomy closure and underwent emergency diversion ileostomy. The Endosponge(A (R)) treatment started after a median of 6.5 (1-158) days after the diagnosis of the leakage and was carried on for a median of 12 (3-42) days. The device was replaced a median of 3 (1-10) times. The median length of hospital stay after the first application of the treatment was 15.5 (6-48) days. The complete healing of the leak was documented in all patients, after a median of 60 (24-90) days from the first treatment. All patients but one had their ileostomy reversed at a median of 2.5 (1-6) months from the confirmation of the complete closure.
   Endosponge(A (R)) is effective as the only treatment after IPAA leak. Based on the results of our prospective pilot study, application of Endosponge(A (R)) should be the treatment of choice in selected pouch anastomotic leaks not requiring immediate surgery. These results will have to be confirmed by future prospective studies including a larger number of patients.
C1 [Rottoli, M.; Di Simone, M. P.; Vallicelli, C.; Vittori, L.; Liguori, G.; Boschi, L.; Poggioli, G.] Alma Mater Studiorum Univ Bologna, St Orsola Malpighi Hosp, Dept Med & Surg Sci, Surg Alimentary Tract, Via Massarenti 9, I-40138 Bologna, Italy.
C3 University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna
RP Rottoli, M (通讯作者)，Alma Mater Studiorum Univ Bologna, St Orsola Malpighi Hosp, Dept Med & Surg Sci, Surg Alimentary Tract, Via Massarenti 9, I-40138 Bologna, Italy.
EM matteo.rottoli2@unibo.it
RI Vallicelli, Carlo/HJH-2906-2023; Rottoli, Matteo/AAC-7258-2022;
   poggioli, gilberto/AAC-7599-2022
OI Rottoli, Matteo/0000-0003-0278-4139; 
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NR 14
TC 31
Z9 35
U1 0
U2 1
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD MAR
PY 2018
VL 22
IS 3
BP 223
EP 229
DI 10.1007/s10151-018-1762-9
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA GA1ED
UT WOS:000428057400008
PM 29502228
DA 2026-07-24
ER
PT J
AU Katarincic, JA
   Fantry, A
   DePasse, JM
   Feller, R
AF Katarincic, Julia A.
   Fantry, Amanda
   DePasse, J. Mason
   Feller, Ross
TI Local Modalities for Preventing Surgical Site Infections: An
   Evidence-based Review
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID PRESSURE WOUND THERAPY; INTRAWOUND VANCOMYCIN POWDER; RESISTANT
   STAPHYLOCOCCUS-AUREUS; POVIDONE-IODINE SOLUTION; TOTAL JOINT
   ARTHROPLASTY; ORTHOPEDIC-SURGERY; CHLORHEXIDINE GLUCONATE; SKIN
   PREPARATION; POSTOPERATIVE INFECTION; ADHESIVE DRAPE
AB Surgical site infections remain a dreaded complication of orthopaedic surgery, affecting both patient economics and quality of life. It is important to note that infections are multifactorial, involving both surgical and patient factors. To decrease the occurrence of infections, surgeons frequently use local modalities, such as methicillin-resistant Staphylococcus aureus screening; preoperative bathing; intraoperative povidone-iodine lavage; and application of vancomycin powder, silver-impregnated dressings, and incisional negative-pressure wound therapy. These modalities can be applied individually or in concert to reduce the incidence of surgical site infections. Despite their frequent use, however, these interventions have limited support in the literature.
C1 [Katarincic, Julia A.; Fantry, Amanda; DePasse, J. Mason; Feller, Ross] Brown Univ, Rhode Isl Hosp, Dept Orthopaed Surg, Warren Alpert Med Sch, Providence, RI 02903 USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University
RP Katarincic, JA (通讯作者)，Brown Univ, Rhode Isl Hosp, Dept Orthopaed Surg, Warren Alpert Med Sch, Providence, RI 02903 USA.
FU Stryker
FX Dr. DePasse or an immediate family member has received nonincome support
   (such as equipment or services), commercially derived honoraria, or
   other non-research-related funding (such as paid travel) from Stryker.
   None of the following authors or any immediate family member has
   received anything of value from or has stock or stock options held in a
   commercial company or institution related directly or indirectly to the
   subject of this article: Dr. Katarincic, Dr. Fantry, and Dr. Feller.
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NR 72
TC 17
Z9 20
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD JAN 1
PY 2018
VL 26
IS 1
BP 14
EP 25
DI 10.5435/JAAOS-D-16-00033
PG 12
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA GA1WH
UT WOS:000428107800003
PM 29261553
DA 2026-07-24
ER
PT J
AU Zhang, HY
   Li, QY
AF Zhang, Hengyan
   Li, Qiyi
TI Improved vacuum sealing drainage for treatment of surgical site
   infection following posterior spinal internal fixation A case report
SO MEDICINE
LA English
DT Article
DE posterior spine surgery; spinal internal fixation; surgical site
   infection; vacuum sealing drainage
ID EXPERIENCE; FUSION
AB Rationale: Surgical site infection (SSI) following spine surgeries involving internal fixation often require removing the instrument; however, this can cause spinal instability. Previous reports have demonstrated the usefulness of vacuum sealing drainage (VSD) therapy, but the cases require wound opening, aseptic condition to replace the VSD device, and a secondary operation to close the wound. Thus, to improve the VSD treatment and develop a maneuverable procedure, make sense in spine surgery.
   Patients concerns: A 59-year-old male patient with a T12 vertebral fracture was affected by SSIs after spinal osteotomy with internal fixation.
   Diagnoses: The patient complained of wound exudation and had a fever 3 weeks after posterior spinal surgery. Initial serum investigations showed elevated white blood cell count and bacterial cultures of wound exudate were positive for Enterococcus faecalis. Therefore, SSI is confirmed.
   Interventions: The infection was not controlled after 2 debridements, so the patient was treated with VSD treatment. The VSD foam dressings containing a drainage tube were placed into the wound from the exudation site of the wound until they contacted the internal fixation devices. After covering external fixation devices, continuous drainage was performed for 24h. The VSD device was replaced every 4 to 5 days until the wound effusion stopped. All of the operations were performed at the bedside without complex manipulation or secondary closure under harsh aseptic condition.
   Outcomes: Wound exudation decreased remarkably and the infection was controlled 2 weeks after the application of VSD treatment. After 5 weeks, inflammatory indicators all decreased to normal levels and the exudate of the wound had stopped. The VSD treatment was then terminated and the drainage site of the wound was sutured. After 7 weeks, complete wound healing was achieved and no infection recurred during the 6-month follow-up.
   Lessons: VSD could be a reliable treatment for SSIs that require preservation of internal fixation. Complete opening of the wound during the VSD treatment and secondary wound closure surgery were avoided.
C1 [Li, Qiyi] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped, 1 Shuaifuyuan, Beijing 100730, Peoples R China.
   [Li, Qiyi] Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100730, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College
RP Li, QY (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped, 1 Shuaifuyuan, Beijing 100730, Peoples R China.; Li, QY (通讯作者)，Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100730, Peoples R China.
EM liqiyipumch@sina.com
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NR 13
TC 4
Z9 6
U1 1
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB
PY 2018
VL 97
IS 7
AR e9952
DI 10.1097/MD.0000000000009952
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GA1ZQ
UT WOS:000428116700060
PM 29443786
OA gold
DA 2026-07-24
ER
PT J
AU Massey, LH
   Pathak, S
   Bhargava, A
   Smart, NJ
   Daniels, IR
AF Massey, L. H.
   Pathak, S.
   Bhargava, A.
   Smart, N. J.
   Daniels, I. R.
TI The use of adjuncts to reduce seroma in open incisional hernia repair: a
   systematic review
SO HERNIA
LA English
DT Review
DE Abdominal wall; Hernia; Mesh; Seroma; Incisional; Negative pressure
   wound therapy
ID NEGATIVE-PRESSURE THERAPY; FIBRIN SEALANT; SUBCUTANEOUS TALC; QUILTING
   SUTURES; PREVENTION; ABDOMINOPLASTY; DISSECTION; CLASSIFICATION;
   PREDICTORS; MASTECTOMY
AB Seroma formation remains a common complication after an incisional hernia repair. The use of surgical drains is widespread, but evidence for their use and other adjuncts is limited. Our aim was to perform a systematic review of the literature on techniques used to reduce the incidence of post-operative seroma formation.
   A systematic search of PubMed and Embase databases was conducted using terms including "incisional hernia" and "seroma". All studies on adults undergoing open incisional hernia repair with at least one intervention designed to reduce seroma formation were included.
   Of the 1093 studies identified, 9 met the inclusion criteria. Medical talc: one cohort study of 74 patients undergoing talc application following pre-peritoneal mesh placement found a significantly decreased rate of seroma formation of 20.8 versus 2.7% (p < 0.001), but a retrospective study including 21 patients with onlay mesh found an increased rate of 76% seroma formation from 9.5% (p = 0.001). Fibrin glue: one comparative study including 60 patients found a reduction in seroma formation from 53 to 10% (p = 0.003), whereas a retrospective study of 250 patients found no difference (11 vs. 4.9% p = 0.07). Negative pressure wound therapy: four retrospective studies including a total of 358 patients found no difference in seroma outcome. Others: one randomised study of 42 patients undergoing either suction drainage or "quilting" sutures found no difference in seroma formation.
   There is currently insufficient quality evidence to recommend any of the investigated methods, some of which incur significant additional cost.
C1 [Massey, L. H.; Smart, N. J.; Daniels, I. R.] Royal Devon & Exeter Hosp, Exeter Surg Hlth Serv Res Unit, Barrack Rd, Exeter EX2 5DW, Devon, England.
   [Pathak, S.] Bristol Royal Infirm & Gen Hosp, Upper Maudlin St, Bristol BS2 8HW, Avon, England.
   [Bhargava, A.] Queen Mary Univ London, Inst Hlth Sci, Mile End Rd, London E1 4NS, England.
C3 University of Exeter; Bristol Royal Infirmary; University of London;
   Queen Mary University London
RP Massey, LH (通讯作者)，Royal Devon & Exeter Hosp, Exeter Surg Hlth Serv Res Unit, Barrack Rd, Exeter EX2 5DW, Devon, England.
EM lisahmassey@gmail.com
RI ; Daniels, Ian/OGR-1767-2025; Smart, Neil/O-2842-2019
OI Massey, Lisa/0000-0002-1699-8034; Daniels, Ian/0000-0002-9114-0812;
   Pathak, Samir/0000-0002-0535-1470; 
FU Medtronic
FX LM declares no conflict of interest. SP declares no conflict of
   interest. AB declares conflict of interest not directly related to the
   submitted work (speaker's fees from Medtronic). NS declares conflict of
   interest not directly related to the submitted work (speaker's fees from
   Medtronic). ID declares conflict of interest not directly related to the
   submitted work (grants, personal fees and non-financial support from
   Medtronic).
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NR 44
TC 23
Z9 27
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2018
VL 22
IS 2
BP 273
EP 283
DI 10.1007/s10029-017-1690-z
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GA3SB
UT WOS:000428248700008
PM 29071497
DA 2026-07-24
ER
PT J
AU Khansa, I
   Janis, JE
AF Khansa, I.
   Janis, J. E.
TI Management of skin and subcutaneous tissue in complex open abdominal
   wall reconstruction
SO HERNIA
LA English
DT Review
DE Abdominal wall reconstruction; Perforator preservation; Panniculectomy;
   Wound healing; Incisional negative pressure wound therapy; Progressive
   tension sutures
ID VENTRAL HERNIA REPAIR; PRESSURE WOUND THERAPY; PROGRESSIVE TENSION
   SUTURES; RANDOMIZED-CONTROLLED-TRIAL; OF-THE-LITERATURE; COMPONENTS
   SEPARATION; INCISION MANAGEMENT; VASCULAR-SURGERY; THIGH FLAP; DEFECTS
AB Open abdominal wall reconstruction is often a complex endeavor, usually performed on patients with multiple risk factors and co-morbidities.
   In this article, we review soft tissue management techniques that can optimize the skin and subcutaneous tissue, with the goal of reducing surgical-site occurrences.
   Regardless of the hernia repair technique used, outcomes can be highly dependent on the appropriate management of the skin and subcutaneous tissue. Indeed, dehiscence and surgical-site infection can jeopardize the entire reconstruction, especially in cases where synthetic mesh might become exposed and/or infected, setting up a "vicious cycle" (Holihan et al. in J Am Coll Surg 221:478-485, 2015).
   Multidisciplinary cooperation between the general and plastic surgeon is useful in cases of tenuous blood supply to the abdominal skin, in cases of redundant, marginal or excessive skin, and in cases of deficient skin.
C1 [Khansa, I.; Janis, J. E.] Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd, Columbus, OH 43212 USA.
C3 University System of Ohio; Ohio State University
RP Janis, JE (通讯作者)，Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd, Columbus, OH 43212 USA.
EM jeffrey.janis@osumc.edu
RI ; Janis, Jeffrey/W-6760-2019
OI Khansa, Ibrahim/0000-0002-7978-6792; Janis, Jeffrey/0000-0001-6103-4798
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NR 52
TC 22
Z9 30
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2018
VL 22
IS 2
BP 293
EP 301
DI 10.1007/s10029-017-1662-3
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GA3SB
UT WOS:000428248700010
PM 28871371
DA 2026-07-24
ER
PT J
AU Deleyto, E
   García-Ruano, A
   González-López, JR
AF Deleyto, E.
   Garcia-Ruano, A.
   Gonzalez-Lopez, J. R.
TI Negative pressure wound therapy with instillation, a cost-effective
   treatment for abdominal mesh exposure
SO HERNIA
LA English
DT Article
DE Abdominal wall; Diagnosis-related groups; Efficiency; Surgical mesh;
   Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; SALINE INSTILLATION; DEHISCENCE; MANAGEMENT;
   REPAIR; HERNIA; ULCERS; TRIAL
AB Negative pressure wound therapy with instillation (NPWTi) has been proved to be a safe and effective treatment option for abdominal wall wound dehiscence with mesh exposure. Our aim in this study is to examine whether it is also cost-effective.
   We performed a retrospective cohort study with 45 patients treated for postoperative abdominal wall wound dehiscence and exposed mesh: 34 were treated with conventional wound therapy (CWT) and 11 with NPWTi. We carried out a cost analysis for each treatment group using the Diagnosis-related group (DRG) system and a second evaluation using the calculated costs "per hospital stay". The differences between NPWTi and CWT were calculated with both evaluation systems. Comparative analysis was performed using the Mann-Whitney U test.
   Mean costs using the DRG estimation were 29,613.71a,notsign for the CWT group and 15,093.37a,notsign for the NPWTi group, and according to the calculated expenses "per hospital stay", 17,322.88a,notsign for the CWT group and 15,284.22a,notsign for the NPWTi group. NPWTi showed a reduction in the total expense of treatment, related to a reduction in episodes of hospitalization and number of surgeries required to achieve wound closure. However, differences were not statistically significant in our sample.
   NPWTi proves to be an efficient treatment option for abdominal wall wound dehiscence with mesh exposure, compared to CWT. More trials aimed to optimize treatment protocols will lead to an additional increase in NPWTi efficiency. In addition, to generalize our results, further studies with larger samples would be necessary.
C1 [Deleyto, E.; Garcia-Ruano, A.] Univ Hosp Gregorio Maranon, Dept Plast Surg, C Dr Esquerdo 46, Madrid 28007, Spain.
   [Gonzalez-Lopez, J. R.] Univ Seville, Fac Nursing Physiotherapy & Podiatry, C Avenzoar 6, E-41009 Seville, Spain.
   [Garcia-Ruano, A.] C Gustavo Bacarisas 2,6 B, Seville 41010, Spain.
C3 General University Gregorio Maranon Hospital; University of Sevilla
RP García-Ruano, A (通讯作者)，Univ Hosp Gregorio Maranon, Dept Plast Surg, C Dr Esquerdo 46, Madrid 28007, Spain.
EM dra.angelagr@gmail.com
RI ; González-López, José Rafael/A-2269-2011
OI Deleyto, Esther/0000-0002-8289-2748; González-López, José
   Rafael/0000-0002-8962-3540
CR Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
   [Anonymous], 2013, B OFICIAL COMUNIDAD
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NR 30
TC 7
Z9 11
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2018
VL 22
IS 2
BP 311
EP 318
DI 10.1007/s10029-017-1691-y
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GA3SB
UT WOS:000428248700012
PM 29086171
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Frazee, R
   Manning, A
   Abernathy, S
   Isbell, C
   Isbell, T
   Kurek, S
   Regner, J
   Smith, R
   Papaconstantinou, H
AF Frazee, Richard
   Manning, Anthony
   Abernathy, Stephen
   Isbell, Claire
   Isbell, Travis
   Kurek, Stanley
   Regner, Justin
   Smith, Randall
   Papaconstantinou, Harry
TI Open vs Closed Negative Pressure Wound Therapy for Contaminated and
   Dirty Surgical Wounds: A Prospective Randomized Comparison
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article; Proceedings Paper
CT 129th Annual Meeting of the Southern-Surgical-Association
CY DEC, 2017
CL Hot Springs, VA
SP So Surg Assoc
ID VACUUM-ASSISTED CLOSURE; OPEN COLORECTAL SURGERY; SITE INFECTION;
   LAPAROTOMY WOUNDS; CONTROLLED-TRIAL; MANAGEMENT; COSTS; EXPERIENCE;
   INCISIONS; SYSTEM
AB BACKGROUND: A new proprietary negative pressure wound device has been developed to apply negative pressure therapy to closed wounds (closed-NPWT). We postulated that closed-NPWT management of contaminated and dirty wounds would lead to faster wound healing and no significant difference in wound complications.
   STUDY DESIGN: An IRB approved, prospective randomized trial was performed. Patients were consented pre-operatively, but not entered nor assigned treatment until intraoperative findings were known. Patients were randomly assigned to either open-NPWT or a wound closed with skin staples and external closed-NPWT. Primary outcome was time to complete wound healing, defined as complete epithelization of the wound. Secondary outcomes were wound complications including wound infection, seroma, and dehiscence. Statistical analysis was performed using chi-square test, Fisher exact test, t-test, and Wilcoxon Rank-Sum test with significance of p < 0.05.
   RESULTS: Twenty-five closed-NPWT and 24 open-NPWT patients were analyzed. There were no significant differences in sex, mean age, BMI, smoking history, steroid use, comorbidities, or indication for surgery in the 2 groups. One patient in the open-NPWT group and 2 patients in the closed-NPWT group developed a wound infection (p = 1.0). Four open-NPWT and 3 closed-NPWT patients died from complications unrelated to the wound. Wound healing occurred at a median of 48 days (range 6 to 126 days) for the open-NPWT group vs a median of 7 days (range 6 to 12 days) for the closed-NPWT group (p < 0.0001).
   CONCLUSIONS: Wound healing was significantly faster in contaminated and dirty wounds when managed with closed-NPWT. There was no difference in wound complications between the 2 treatment groups. This approach shows promise for closed management of contaminated and dirty wounds and warrants additional prospective studies with larger patient groups. (C) 2017 by the American College of Surgeons. Published by Elsevier Inc. All rights reserved.
C1 [Frazee, Richard; Manning, Anthony; Abernathy, Stephen; Isbell, Claire; Isbell, Travis; Kurek, Stanley; Regner, Justin; Smith, Randall; Papaconstantinou, Harry] Baylor Scott & White Healthcare, Dept Surg, Div Trauma & Acute Care Surg, Temple, TX USA.
C3 Baylor Scott & White Health
RP Frazee, R (通讯作者)，Scott & White Healthcare, Texas A&M Hlth Sci Ctr, Coll Med, Trauma & Acute Care Surg, 2401 South 31st St, Temple, TX 76502 USA.
EM Rfrazee@sw.org
RI ; Papaconstantinou, Harry/HTM-6474-2023
OI Kurek, Stanley/0000-0001-6608-5404; 
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NR 22
TC 40
Z9 49
U1 1
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD APR
PY 2018
VL 226
IS 4
BP 507
EP 512
DI 10.1016/j.jamcollsurg.2017.12.008
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA GA4KM
UT WOS:000428298600024
PM 29274840
DA 2026-07-24
ER
PT J
AU Shim, HS
   Choi, JS
   Kim, SW
AF Shim, Hyung Sup
   Choi, Ji Seon
   Kim, Sang Wha
TI A Role for Postoperative Negative Pressure Wound Therapy in Multitissue
   Hand Injuries
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; UPPER EXTREMITY;
   MANAGEMENT; SURGERY; TRAUMA
AB In this study, we compared outcomes in patients with acute hand injury, who were managed with or without negative pressure wound therapy (NPWT) after reconstructive surgery. All of the patients who sustained acute and multitissue injuries of the hand were identified. After reconstructive surgery, a conventional dressing was applied in Group 1 and NPWT was applied in Group 2. The dressing and NPWT were changed every 3 days. The mean age and Hand Injury Severity Scoring System score of both groups were not significantly different. Disabilities of the Arm, Shoulder, and Hand( DASH) scores were evaluated 1 month after all the sutures were removed and 1 year postoperatively, which were both significantly lower in Group 2. Applying NPWT to the hand promoted wound healing by reducing edema, stabilizing the wound, and providing immobilization in a functional position. Early wound healing and decreased complications enabled early rehabilitation, which led to successful functional recovery, both objectively and subjectively.
C1 [Shim, Hyung Sup; Choi, Ji Seon] Catholic Univ Korea, Dept Plast & Reconstruct Surg, Coll Med, St Vincent Hosp, Seoul, South Korea.
   [Kim, Sang Wha] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Plast & Reconstruct Surg, Coll Med, Seoul, South Korea.
C3 Catholic University of Korea; Seoul National University (SNU); Seoul
   National University Hospital
RP Kim, SW (通讯作者)，Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Plast & Reconstruct Surg, Coll Med, Seoul, South Korea.
EM sw1215@snu.ac.kr
RI Shim, Hyung-Sup/AAA-5473-2022
OI Kim, Sang Wha/0000-0003-0430-3458
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
   Borgquist O, 2010, PLAST RECONSTR SURG, V125, P502, DOI 10.1097/PRS.0b013e3181c82e1f
   Campbell DA, 1996, J HAND SURG-BRIT EUR, V21B, P295, DOI 10.1016/S0266-7681(05)80187-1
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   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
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   Kairinos N, 2010, J PLAST RECONSTR AES, V63, P174, DOI 10.1016/j.bjps.2008.08.037
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
   Kim YH, 2015, J WOUND CARE, V24, P536, DOI 10.12968/jowc.2015.24.11.536
   Liu DSH, 2012, INJURY, V43, P772, DOI 10.1016/j.injury.2011.09.003
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   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Patel RM, 2012, J HAND SURG-AM, V37A, P803, DOI 10.1016/j.jhsa.2011.12.030
   Stepien Robert, 2014, Pol Orthop Traumatol, V79, P82
   Streubel PN, 2012, J AM ACAD ORTHOP SUR, V20, P564, DOI 10.5435/JAAOS-20-09-564
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   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 23
TC 18
Z9 26
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2018
VL 2018
AR 3629643
DI 10.1155/2018/3629643
PG 7
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA GA5YN
UT WOS:000428410000001
PM 29780821
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Dingemans, SA
   Birnie, MFN
   Backes, M
   de Jong, VM
   Luitse, JS
   Goslings, JC
   Schepers, T
AF Dingemans, Siem A.
   Birnie, Merel F. N.
   Backes, Manouk
   de Jong, Vincent M.
   Luitse, Jan S.
   Goslings, J. Carel
   Schepers, Tim
TI Prophylactic negative pressure wound therapy after lower extremity
   fracture surgery: a pilot study
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
DE Negative pressure wound therapy; Postoperative wound infection; Lower
   extremity fracture surgery; Prophylactic; Closed incision
ID SURGICAL INCISIONS; TRAUMA; INFECTIONS; TRIAL
AB Purpose Infectious complications following lower extremity fracture surgery are a major concern and account for a substantial socio-economic burden to society. The aim of this pilot study was to investigate the feasibility of a new portable single-use negative pressure wound therapy device in patients undergoing major foot ankle surgery.
   Methods Patients undergoing major foot ankle fracture surgery at a single level 1 trauma centre were eligible for this prospective case series. Patient characteristics were collected, as were fracture and surgical characteristics. Primary outcome was surgical site infection within 30 days as classified by the criteria from the Centers for Disease Control and Prevention. Patients in the prospective cohort were case-matched with a historical cohort from the same institution.
   Results Sixty patients were included. In seven patients, the NPWT failed and treatment was ceased. Mean age was 44 years and 85% was ASA 1; 43% of the patients were actively smoking. Indications for surgery were midfoot, calcaneal, talar, and ankle fractures. In 53 patients, four (7.5%) surgical site infections occurred, two superficial (3.3%) and two (3.3%) deep infections. For 47 patients, a match was available. The incidence of surgical site infection did not statistically significantly differ between the prospective cohort and retrospective matched cohort (4.3 versus 14.9%, p = 0.29, respectively). This was also the case when looking at superficial and deep surgical site infections separately (0 versus 8.5%, p = 0.08, and 4.3 versus 6.4%, respectively).
   Conclusion We have observed surgical site infections in 7.5% of the patients with the use of prophylactic negative pressure wound therapy. The incidence of surgical site infections was not statistically significantly lower compared to a matched historical cohort.
C1 [Dingemans, Siem A.; Birnie, Merel F. N.; Backes, Manouk; de Jong, Vincent M.; Luitse, Jan S.; Goslings, J. Carel; Schepers, Tim] Acad Med Ctr, Trauma Unit, Dept Surg, Meibergdreef 9,POB 22660, NL-1100 DD Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam
RP Schepers, T (通讯作者)，Acad Med Ctr, Trauma Unit, Dept Surg, Meibergdreef 9,POB 22660, NL-1100 DD Amsterdam, Netherlands.
EM t.schepers@amc.nl
OI Schepers, Tim/0000-0003-1172-4939
FU Smith Nephew ltd [IIS 377]
FX This study was funded by a grant (IIS 377) from Smith & Nephew ltd.
CR Backes M, 2015, ARCH ORTHOP TRAUM SU, V135, P1045, DOI 10.1007/s00402-015-2219-5
   Berrios-Torres SI, 2017, JAMA SURG, P1
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NR 20
TC 20
Z9 20
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD APR
PY 2018
VL 42
IS 4
BP 747
EP 753
DI 10.1007/s00264-018-3781-6
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA GA8PT
UT WOS:000428602900003
PM 29376199
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Csiszkó, A
   Balog, K
   Godó, ZA
   Juhász, G
   Peto, K
   Deák, A
   Berhés, M
   Németh, N
   Bodnár, Z
   Szentkereszty, Z
AF Csiszko, Adrienn
   Balog, Klaudia
   Godo, Zoltan Attila
   Juhasz, Gyula
   Peto, Katalin
   Deak, Adam
   Berhes, Mariann
   Nemeth, Norbert
   Bodnar, Zsolt
   Szentkereszty, Zsolt
TI Pressure Distribution during Negative Pressure Wound Therapy of
   Experimental Abdominal Compartment Syndrome in a Porcine Model
SO SENSORS
LA English
DT Article
DE intra-abdominal pressure; abdominal compartment syndrome; pressure
   sensor; negative ressure wound therapy; open abdomen
ID MICROVASCULAR BLOOD-FLOW; OPEN ABDOMEN; INTRAABDOMINAL PRESSURE; CLOSURE
   TECHNIQUES; INTESTINAL WALL; ANIMAL-MODEL; HYPERTENSION; DECOMPRESSION;
   MANAGEMENT
AB (1) Introduction: Negative pressure wound therapy (NPWT) is a frequently applied open abdomen (OA) treatment. There are only a few experimental data supporting this method and describing the optimal settings and pressure distribution in the abdominal cavity during this procedure. The aim of our study was to evaluate pressure values at different points in the abdominal cavity during NPWT in experimental abdominal compartment syndrome (ACS) animal model; (2) Methods: In this study (permission Nr. 13/2014/UDCAW), 27 Hungahib pigs (15.4-20.2 kg) were operated on. ACS was generated by implanting a plastic bag in the abdomen through mini-laparotomy and filled with 2100-3300 mL saline solution (37 degrees C) to an intraabdominal pressure (IAP) of 30 mmHg. After 3 h, NPWT (Vivano Med (R) Abdominal Kit, Paul Hartmann AG, Germany) or a Bogota bag was applied. The NPWT group was divided into -50, -100 and -150 mmHg suction groups. Pressure distribution to the abdominal cavity was monitored at 6 different points of the abdomen via a multichannel pressure monitoring system; (3) Results: The absolute pressure levels were significantly higher above than below the protective layer. The values of the pressure were similar in the midline and laterally. Amongst the bowels, the pressure values changed periodically between 0 and -12 mmHg which might be caused by peristaltic movements; (4) Conclusions: The porcine model of the present study seems to be well applicable for investigating ACS and NPWT. It was possible to provide valuable information for clinicians. The pressure was well distributed by the protective layer to the lateral parts of the abdomen and this phenomenon did not change considerably during the therapy.
C1 [Csiszko, Adrienn; Balog, Klaudia; Szentkereszty, Zsolt] Univ Debrecen, Fac Med, Inst Surg, Egyet Ter 1, H-4032 Debrecen, Hungary.
   [Godo, Zoltan Attila; Juhasz, Gyula] Univ Debrecen, Fac Informat, Dept Informat Technol, Egyet Ter 1, H-4032 Debrecen, Hungary.
   [Peto, Katalin; Deak, Adam; Nemeth, Norbert] Univ Debrecen, Fac Med, Dept Operat Tech & Surg Res, Egyet Ter 1, H-4032 Debrecen, Hungary.
   [Berhes, Mariann] Univ Debrecen, Fac Med, Dept Anaesthesiol & Intens Care, Egyet Ter 1, H-4032 Debrecen, Hungary.
   [Bodnar, Zsolt] Letterkenny Univ Hosp, Dept Surg, Letterkenny F92VX8D, Ireland.
C3 University of Debrecen; University of Debrecen; University of Debrecen;
   University of Debrecen
RP Bodnár, Z (通讯作者)，Letterkenny Univ Hosp, Dept Surg, Letterkenny F92VX8D, Ireland.
EM csiszko@gmail.com; klaudia.balog@live.com; magortaltos@gmail.com;
   gyuszi32@gmail.com; kpeto@med.unideb.hu; deak.adam@med.unideb.hu;
   bermarjan@yahoo.co.uk; nemeth@med.unideb.hu; drbozsolt@gmail.com;
   szentkerzs@gmail.com
RI Petö, Katalin/IWD-5161-2023; Nemeth, Norbert/AAX-8704-2020
OI Nemeth, Norbert/0000-0002-1162-3778; Deak, Adam/0000-0001-7516-3152
CR Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
   Benninger E, 2009, J TRAUMA, V66, P1118, DOI 10.1097/TA.0b013e3181820d94
   Bjarnason T, 2011, WORLD J SURG, V35, P917, DOI 10.1007/s00268-010-0937-y
   Bruhin A, 2014, INT J SURG, V12, P1105, DOI 10.1016/j.ijsu.2014.08.396
   Coccolini F, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0026-5
   Correa-Martín L, 2013, J SURG RES, V184, P1028, DOI 10.1016/j.jss.2013.04.041
   Demetriades D, 2014, SURG CLIN N AM, V94, P131, DOI 10.1016/j.suc.2013.10.010
   Elvevoll Bjorg, 2014, BMC Res Notes, V7, P738, DOI 10.1186/1756-0500-7-738
   Hlebowicz J, 2012, INT J COLORECTAL DIS, V27, P397, DOI 10.1007/s00384-011-1317-2
   Huang Q, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/2073260
   Ke L, 2013, J TRAUMA ACUTE CARE, V74, P1060, DOI 10.1097/TA.0b013e318283d927
   Ke L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033125
   Kirkpatrick AW, 2015, ANAESTH INTENSIVE TH, V47, pS63, DOI 10.5603/AIT.a2015.0081
   Kirkpatrick AW, 2009, CRIT CARE MED, V37, P591, DOI 10.1097/CCM.0b013e3181954491
   Lessing MC, 2013, EPLASTY, V13, pe51
   Lindstedt S, 2015, INT WOUND J, V12, P83, DOI 10.1111/iwj.12056
   Olofsson PH, 2009, CRIT CARE MED, V37, P230, DOI 10.1097/CCM.0b013e318192ff51
   Otto J, 2010, SHOCK, V33, P639, DOI 10.1097/SHK.0b013e3181cb8be0
   Schachtrupp A, 2007, ACTA CLIN BELG, V62, P225, DOI 10.1179/acb.2007.62.s1.031
   Skoog P, 2014, EUR J VASC ENDOVASC, V47, P402, DOI 10.1016/j.ejvs.2014.01.007
   Suh H., 2014, ANN PLAST SURG, V76, P717
   Yoshino O, 2012, INJURY, V43, P169, DOI 10.1016/j.injury.2011.04.011
NR 22
TC 4
Z9 6
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1424-8220
J9 SENSORS-BASEL
JI Sensors
PD MAR
PY 2018
VL 18
IS 3
AR 897
DI 10.3390/s18030897
PG 11
WC Chemistry, Analytical; Engineering, Electrical & Electronic; Instruments
   & Instrumentation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Instruments & Instrumentation
GA GB1IU
UT WOS:000428805300218
PM 29562626
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Adeyemi, A
   Waycaster, C
AF Adeyemi, Ayoade
   Waycaster, Curtis
TI Cost-minimization Analysis of Negative Pressure Wound Therapy in
   Long-term Care Facilities
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE Negative Pressure Wound Therapy; single-use; traditional; cost
   minimization
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; DIABETIC FOOT
   ULCERS; MULTICENTER
AB Objective. This study aims to conduct a cost-minimization analysis comparing wound treatment costs between single-use negative pressure wound therapy (sNPWT) and traditional negative pressure wound therapy (tNPWT).
   Materials and Methods. Assuming comparable outcomes, cost data obtained from the ECRI Institute were compared between the 2 NPWT options using data extracted from an electronic wound management program between August 2010 and March 2016. Results. Use of sNPWT versus tNPWT resulted in daily and total treatment duration cost savings of $55 and $1586, respectively. Conclusions. Long-term care facilities can potentially accrue significant cost savings by using sNPWT instead of tNPWT on a majority of eligible wounds.
   As of 2014, $28.1 billion was a conservative estimate of health care costs for the 8.2 million Medicare beneficiaries with >= 1 type of wound or wound-related infection in the United States. 1 Evidence supporting superior clinical outcomes of negative pressure wound therapy (NPWT) versus standard of care include promotion of granulation tissue formation, reduced time to wound closure, and increased proportion of wounds that achieve closure for diabetic foot ulcers, venous leg ulcers, and full-thickness wounds. 2-5Although NPWT can lower costs by reducing treatment duration and health care resource use, 6,7 the cost of prolonged wound care can be significant.
   Traditional NPWT (tNPWT) systems use large, reusable electrical pumps to deliver negative pressure while single-use NPWT (sNPWT; PICO; Smith & Nephew, Fort Worth, TX) are portable systems designed for single-use and assumed to have comparable clinical outcomes as tNWPT, with the potential to reduce wound care costs compared with tNPWT. 8-11 To examine this possibility, the authors identified the proportion of wounds on tNPWT amenable to sNPWT based on certain wound characteristics and estimated through a cost-minimization analysis whether the use of sNPWT compared with tNPWT systems could result in cost savings for long-term health care facilities (LCFs).
C1 [Adeyemi, Ayoade; Waycaster, Curtis] Smith & Nephew Inc, 150 Minuteman Rd, Andover, MA 01810 USA.
C3 Smith & Nephew
RP Adeyemi, A (通讯作者)，Smith & Nephew Inc, 150 Minuteman Rd, Andover, MA 01810 USA.
EM Ayoade.Adeyemi@smith-nephew.com
FU Smith Nephew, Inc.
FX This study was funded by Smith & Nephew, Inc. Both authors are paid
   employees of Smith & Nephew. Joann Hettasch, PhD (Fishawack
   Communications, Inc, Conshohocken, PA), provided medical writing
   support.
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Centers for Medicare and Medicaid Services, DUR MED EQ PROSTH OR
   Crawford Malik., 2016, CPI Detailed Report Data for January 2016
   Driver VR, 2014, J AM PODIAT MED ASSN, V104, P147, DOI 10.7547/0003-0538-104.2.147
   ECRI Institute, 2018, PRICEGUIDE
   Gabriel A, 2013, INT WOUND J, V10, P418, DOI 10.1111/j.1742-481X.2012.00999.x
   Hurd T, 2014, OSTOMY WOUND MANAG, V60, P30
   Mouës CM, 2007, J PLAST RECONSTR AES, V60, P672, DOI 10.1016/j.bjps.2006.01.041
   Nussbaum SR, 2018, VALUE HEALTH, V21, P27, DOI 10.1016/j.jval.2017.07.007
   Pennsylvania Patient Safety Advisory, 2011, PA PATIENT SAF ADVIS, V8, P18
   Sullivan N, 2009, NEGATIVE PRESSURE WO
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 15
TC 5
Z9 5
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2018
VL 30
IS 2
BP E13
EP +
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GB3XM
UT WOS:000428993700002
PM 29481332
DA 2026-07-24
ER
PT J
AU Griffin, L
   Casillas, LL
AF Griffin, Leah
   Casillas, Laura Leyva
TI Evaluating the Impact of a Patient-centered Remote Monitoring Program on
   Adherence to Negative Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE remote therapy monitoring; Negative Pressure Wound Therapy; patient
   adherence
AB A remote therapy monitoring (RTM) system has been developed for use with a negative pressure wound therapy (NPWT) unit for patients in the home care setting. In conjunction with RTM, a network of trained professionals call patients when their NPWT usage is low and provide education to assist with therapy adherence.
   Objective. The objective of this evaluation is to examine the relationship between the RTM system and patient adherence. Materials and Methods. One hundred ninety-eight home care patients receiving NPWT with RTM between December 2016 and April 2017 were included. Results. A total of 979 calls were made, with an average of 4.9 calls per patient. Among 198 patients, 195 received a welcome call, 157 received a call due to low adherence, and 35 had an escalation call made to their treating nurse. Of the 157 patients who required at least 1 call due to low adherence, 153 were successfully contacted at least once. The day following the patient call, adherence increased 73% of the time by an average of 8.5 hours. Conclusions. This evaluation suggests there is an ability to influence patient adherence through active engagement, potentially improving outcomes and reducing wound costs.
   The World Health Organization has estimated that 50% of those living with chronic illness are nonadherent to their prescribed therapy. 1 Estimates indicate that wounds account for nearly 4% of health care system costs, and that number is rising. 2 In an internal retrospective study of more than 1800 patients, increasing adherence to negative pressure wound therapy (NPWT) use has been shown to facilitate wound closure ( unpublished data, 2017). This led to a hypothesis that with active patient engagement, the rate of adherence to therapy could be affected. Recently, a proprietary remote therapy monitoring ( RTM) system (iOn PROGRESS Remote Therapy Monitoring; Acelity, San Antonio, TX) has been developed to provide timely feedback on patient adherence to wound management. The RTM system works in conjunction with a NPWT system (ACTIV.A.C. Therapy System; Acelity) to monitor patient compliance beyond the hospital setting. The objective of this evaluation is to examine the relationship between RTM and patient adherence to NPWT.
   MATERIALS AND METHODS This study included 198 patients receiving NPWT with RTM between December 2016 and April 2017. A connectivity module on the NPWT device enabled continuous RTM for patients receiving NPWT at home ( Figure 1). In conjunction with RTM, a network of trained professionals (iOn PROGRESS Care Network, Acelity) was available to contact patients and provide education to assist with therapy adherence. Patients with therapy usage < 16 hours in 1 day received an adherence call. Therapy usage leading up to and following the adherence call was measured using the RTM data. Failure to initially reach a patient or consistent noncompliance (ie, patient not reached following second adherence call within a 7-day period) triggered an escalation call to the patient's caregiver to discuss therapy adherence.
C1 [Griffin, Leah; Casillas, Laura Leyva] Acelity, 12930 West Interstate 10, San Antonio, TX 78249 USA.
RP Griffin, L (通讯作者)，Acelity, 12930 West Interstate 10, San Antonio, TX 78249 USA.
EM Leah.Griffin@kci1.com
FU Kinetic Concepts Inc, an Acelity Company, San Antonio, TX
FX Financial support for this research was provided by Kinetic Concepts
   Inc, an Acelity Company, San Antonio, TX. Mikaela Sifuentes, PhD,
   (Acelity) provided medical writing support.
CR Chisholm-Burns MA, 2012, J AM PHARM ASSOC, V52, P823, DOI 10.1331/JAPhA.2012.11088
   Drew Philip, 2007, Int Wound J, V4, P149, DOI 10.1111/j.1742-481X.2007.00337.x
NR 2
TC 0
Z9 0
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2018
VL 30
IS 3
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GB3XQ
UT WOS:000428994200002
DA 2026-07-24
ER
PT J
AU Ooi, G
   Burton, P
   Packiyanathan, A
   Loh, D
   Chen, R
   Shaw, K
   Brown, W
   Nottle, P
AF Ooi, Geraldine
   Burton, Paul
   Packiyanathan, Andrew
   Loh, Damien
   Chen, Richard
   Shaw, Kalai
   Brown, Wendy
   Nottle, Peter
TI Indications and efficacy of endoscopic vacuum-assisted closure therapy
   for upper gastrointestinal perforations
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE anastomotic leak; gastroscopy; negative-pressure wound therapy;
   oesophageal perforation; oesophagectomy
ID ANASTOMOTIC LEAKAGE; TREATMENT OPTIONS; MANAGEMENT; RESECTION
AB BackgroundEndoscopic vacuum-assisted closure (EndoVAC) therapy is a recent innovation described for use in upper gastrointestinal perforations and leaks, with reported success of 80-90%. It provides sepsis control and collapses the cavity preventing stasis, encouraging healing of the defect. Whilst promising, initial reports of this new technique have not established clear indications, feasibility and optimal technique.
   MethodsWe analysed all patients who underwent EndoVAC therapy between 2014 and 2016. The technique involved a standard gastroscope, nasogastric tube and vacuum-assisted closure dressing kit, with endoscopic placement of the polyurethane sponge. Data were collected on indication, technique, sepsis control, outcomes and drainage volumes.
   ResultsTen patients were treated. Average age was 56.712.3years. There were three mortalities. EndoVAC placement was feasible in nine patients and successful healing was observed in six patients. Failure was more likely in the cases of large (>8cm), chronic or complex cavities. A three-phase response was seen in successful cases, with initial reduction in external drainage (average: 143-17mL/day within 1week), followed by a progressive reduction in inflammatory markers (2weeks) and finally a healing phase with reduction in cavity size (3weeks).
   Conclusion EndoVAC therapy is a potentially useful adjunct to conventional treatments of a subset of upper gastrointestinal leaks and perforations when there is a contained cavity <8cm. It appears less effective in an uncontained perforation or chronically established tract. It has clear advantages of being easily applied with readily available equipment and disposables.
C1 [Ooi, Geraldine; Burton, Paul; Packiyanathan, Andrew; Loh, Damien; Chen, Richard; Shaw, Kalai; Brown, Wendy; Nottle, Peter] Alfred Hosp, Upper Gastrointestinal Surg Unit, Melbourne, Vic, Australia.
   [Ooi, Geraldine; Burton, Paul; Brown, Wendy] Monash Univ, Ctr Obes Res & Educ, Level 6,99 Commercial Rd, Melbourne, Vic 3181, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Monash University
RP Ooi, G (通讯作者)，Monash Univ, Ctr Obes Res & Educ, Level 6,99 Commercial Rd, Melbourne, Vic 3181, Australia.
EM geraldine.ooi@monash.edu
RI Brown, Wendy/H-7130-2014
OI Brown, Wendy/0000-0002-0137-2688
FU Allergan, Inc.; National Health and Medical Research Council; Royal
   Australasian College of Surgeons
FX The Centre for Obesity Research and Education has received funding for
   research purposes from Allergan, Inc., the manufacturer of the LAP-BAND.
   Dr Ooi reports scholarships from the National Health and Medical
   Research Council and the Royal Australasian College of Surgeons. The
   remaining authors have no conflicts of interest.
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NR 18
TC 36
Z9 44
U1 2
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD APR
PY 2018
VL 88
IS 4
BP E257
EP E263
DI 10.1111/ans.13837
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GB3XS
UT WOS:000428994400007
PM 27860126
DA 2026-07-24
ER
PT J
AU Tu, KK
   Li, H
   Bai, BL
   Weng, SJ
   Wu, ZY
   Boodhun, V
   Feng, ZH
   Cheng, L
   Yang, L
AF Tu, Kai-Kai
   Li, Hang
   Bai, Bing-Li
   Weng, She-Ji
   Wu, Zong-Yi
   Boodhun, Viraj
   Feng, Zhen-Hua
   Cheng, Liang
   Yang, Lei
TI Intra- and extramedullary fixation combined with vacuum sealing drainage
   for selective treatment of open tibial fractures: a retrospective case
   series
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Titanium elastic nails; external fixator; open tibial fractures; vacuum
   sealing drainage
ID PRESSURE WOUND THERAPY; ILIZAROV EXTERNAL FIXATION; PLATE
   OSTEOSYNTHESIS; RANDOMIZED-TRIAL; DISTAL TIBIA; MANAGEMENT; BONE;
   DIAPHYSEAL; CLOSURE; FEMUR
AB The objective of this study was to introduce a novel method of percutaneous titanium elastic nails augmented by unilateral external fixator (BioEF-TENs system) combined with vacuum sealing drainage (VSD) technique and evaluate the effects in the management of open fractures of tibia. From January 2011 to June 2013, 15 patients (11M/4F) with a mean age of 41.6 years (16-60 years) were treated with this method. According to the Anderson-Gustilo classification, there were 3 cases defined as Gustilo I, 5 as Gustilo II, 3 as Gustilo IIIA, 2 as Gustilo IIIB and 2 as Gustilo IIIC. Follow-up was done at 1, 2, 3 months postoperatively, and then at 2 months intervals, to conduct clinical and radiographic examinations. The mean follow-up period of 15 patients was 18 months. After the VSD was removed, 3 patients needed skin-grafting and 2 case needed flap coverage. The external fixator was removed with a mean time of 23.3 weeks (18-45 weeks), the average union time is 29.8 weeks (21-56 weeks). Delayed union was observed in 3 patients and there was no case with mal-union. There were 3 cases with pin track infection which were treated after external fixator removal. Superficial wound infection was existed in one patient and was cured by intravenous sensitive antibiotics and VSD. No case was observed with decrease ROM or pain of the knee. And only one patient's ankle joint range of movement (ROM) was decreased by 20-25%. The results indicated that the BioEF-TENs system combined with VSD can achieve bone stability at one stage fixation operation, which not only avoids converting fixation but also obtains effective soft tissue protection, which is a novel technique for open fractures of tibia with certain indications and worthy for further research.
C1 [Tu, Kai-Kai] Xiaoshan Tradit Chinese Med Hosp, Dept Orthoped Surg, Hangzhou, Zhejiang, Peoples R China.
   [Li, Hang; Bai, Bing-Li; Weng, She-Ji; Wu, Zong-Yi; Boodhun, Viraj; Feng, Zhen-Hua; Cheng, Liang; Yang, Lei] Wenzhou Med Univ, Dept Orthopaed Surg, Affiliated Hosp 2, Wenzhou, Zhejiang, Peoples R China.
   [Li, Hang; Bai, Bing-Li; Weng, She-Ji; Wu, Zong-Yi; Boodhun, Viraj; Feng, Zhen-Hua; Cheng, Liang; Yang, Lei] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University
RP Yang, L (通讯作者)，Wenzhou Med Univ, Dept Orthopaed Surg, Affiliated Hosp 2, Wenzhou, Zhejiang, Peoples R China.; Yang, L (通讯作者)，Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China.
EM lihtc@163.com
CR [Anonymous], PERCUTANEOUS MINIMAL
   [Anonymous], ZHEJIANG MED J
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NR 32
TC 1
Z9 1
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 3
BP 2248
EP 2255
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GB4BZ
UT WOS:000429006600094
DA 2026-07-24
ER
PT J
AU de Jesus, LE
   Martins, AB
   Oliveira, PB
   Gomes, F
   Leve, T
   Dekermacher, S
AF de Jesus, Lisieux Eyer
   Martins, Alana Bandeira
   Oliveira, Pablo Baptista
   Gomes, Fernanda
   Leve, Thais
   Dekermacher, Samuel
TI Negative pressure wound therapy in pediatric surgery: How and when to
   use
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE NPWT, negative pressure wound therapy; ACS, abdominal compartment
   syndrome; SIH, second intention healing; PSC, Pediatric Surgical Cases;
   ECMO, extracorporeal membrane oxygenation
ID VACUUM-ASSISTED CLOSURE; NECROTIZING ENTEROCOLITIS; ABDOMINAL CLOSURE;
   COMPLEX WOUNDS; OPEN ABDOMEN; MANAGEMENT; CHILDREN; EXPERIENCE; INFANTS;
   LAPAROTOMY
AB Introduction: Negative pressure wound therapy (NPWT) has been widely adopted to treat laparostomy, abdominal compartment syndrome (ACS) and complicated wounds associated with tissue loss. The method presents specific aspects, advantages and indications in Pediatrics. Our aim is to review the evidence available about NPWT in children.
   Methods: Active search for papers about NPWT in Pediatric patients. Papers referring to orthopedic problems, wound complications after Cardiac Surgery or burns were excluded.
   Results: The method shows good results to treat ACS, complicated wounds and abdominal wall malformations in neonates, including prematures. Periwound skin protection, monitoring of fluid losses and fine tuning of negative pressure levels according to age are necessary. Less pain, quicker recovery, less frequent dressing changes, possible recovery of exposed surgical hardware, granulation and shrinkage of the wound are advantages of the method over other kinds of dressing. NPWT is contraindicated over blood vessels and exposed nerves. Debridement is needed before usage over necrotic areas. Enteric fistulae are not contraindications. Complications are rare, mainly foam retention and dermatitis/skin maceration. The possibility of fistulae being caused by NPWT remains debatable.
   Conclusion: NPWT is widely used in Pediatrics, including neonates and premature, but the evidence available about the method is scarce and low quality. Complications are uncommon and mostly manageable. A possible causal relationship between NPWY and enteric fistula remains unclear. Adult devices and parameters have been adapted to children's use. Extra care is needed to protect the delicate tissues of Pediatric patients. Comparative research to define differential costs, indications and advantages of the method, specific indications and limits of NWTP in Pediatrics is needed.
   Type of study: Review.
   Evidence level: IV (c) 2017 Elsevier Inc. All rights reserved.
C1 [de Jesus, Lisieux Eyer; Martins, Alana Bandeira; Oliveira, Pablo Baptista; Gomes, Fernanda; Leve, Thais; Dekermacher, Samuel] Minist Hlth, Serv Estado Fed Hosp, Pediat Surg & Urol Dept, Rio De Janeiro, Brazil.
RP de Jesus, LE (通讯作者)，52 Presidente Domiciano Apt 801, BR-24210270 Rio De Janeiro, RJ, Brazil.
EM lisieux@uol.com.br
RI de Jesus, Lisieux/H-3811-2014
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NR 42
TC 36
Z9 40
U1 0
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD APR
PY 2018
VL 53
IS 4
BP 585
EP 591
DI 10.1016/j.jpedsurg.2017.11.048
PG 7
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA GB8CF
UT WOS:000429301400001
PM 29241963
DA 2026-07-24
ER
PT J
AU Fleming, CA
   Kuteva, M
   O'Hanlon, K
   O'Brien, G
   McGreal, G
AF Fleming, C. A.
   Kuteva, M.
   O'Hanlon, K.
   O'Brien, G.
   McGreal, G.
TI Routine use of PICO dressings may reduce overall groin wound
   complication rates following peripheral vascular surgery
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE Peripheral vascular surgery; Groin wound infection; Groin wound
   complication; Groin wound seroma; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTION; LOWER-EXTREMITY
   BYPASS; SZILAGYI GRADE III; RISK-FACTORS; LAPAROTOMY WOUNDS; THERAPY;
   PREVENTION; MANAGEMENT; SYSTEM
AB Background: Approximately 19% of morbidity in peripheral vascular surgery is attributable to wound complications, which can result in delayed healing, and also arterial or graft infection leading to limb loss and even mortality in extreme cases.
   Aim: To determine whether groin wound complications were reduced following the routine introduction of PICO negative pressure wound therapy dressings in patients who underwent peripheral vascular surgery.
   Methods: Patients who underwent peripheral vascular surgery from 2011 to 2016 were identified and divided into PICO and non-PICO groups. Patient, procedure and wound characteristics were tabulated and analysed. Patients were followed-up for at least six weeks postoperatively. Wound complication rates, infection confirmed by microbiology, and requirement for re-admission due to wound complications were noted. Basic cost analysis was performed.
   Findings: In total, 151 patients were analysed (N = 73 PICO, N = 78 non-PICO). No difference in age (P = 0.862), body mass index (P = 0.673), diabetes (P = 0.339), preoperative albumin (P = 0.196), use of drain (P = 0.343) and history of meticillin-resistant Staphylococcus aureus (P = 0.281) was observed between groups. The PICO group contained more smokers than the non-PICO group (45% vs 29%, P = 0.034). Wound complications were seen in 8% (N = 6) of the PICO group and 19% (N = 15) of the non-PICO group (P = 0.042). No significant difference in infection was found between the two groups (3% vs 6%, P = 0.249), but fewer seromas were observed when PICO dressings were used (1.4% vs 7.7%, P = 0.069). Haematoma (2.7% vs 3.8%, P = 0.531) and dehiscence rates (1.4% vs 1.3%, P = 0.735) were similar between the two groups.
   Conclusions: Routine use of PICO dressings is associated with a reduction in wound complication rates following peripheral vascular surgery, and is cost-effective. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
C1 [Fleming, C. A.; Kuteva, M.; O'Hanlon, K.; O'Brien, G.; McGreal, G.] Mercy Univ Hosp, Dept Vasc Surg, Cork, Ireland.
C3 University College Cork
RP Fleming, CA (通讯作者)，Mercy Univ Hosp, Dept Vasc Surg, Cork, Ireland.
EM christina.fleming49@gmail.com
OI Wang, Shuang/0009-0005-5511-8027
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   Saziye K, 2015, VASCULAR, V23, P144, DOI 10.1177/1708538114537488
   Saziye K, 2011, INT WOUND J, V8, P229, DOI 10.1111/j.1742-481X.2011.00773.x
   Slappy A L Jackson, 2003, Vasc Endovascular Surg, V37, P105
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Tan A, 2014, INT J SURG, V12, P26, DOI 10.1016/j.ijsu.2013.11.002
   Verma H, 2015, INT WOUND J, V12, P317, DOI 10.1111/iwj.12110
   von Elm E, 2007, LANCET, V370, P1453, DOI 10.1002/ana.22307
   Wallaert JB, 2012, J VASC SURG, V56, P1317, DOI 10.1016/j.jvs.2012.04.011
   Zhang JQ, 2014, J VASC SURG, V59, P1331, DOI 10.1016/j.jvs.2013.12.032
NR 30
TC 21
Z9 22
U1 0
U2 7
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD MAY
PY 2018
VL 99
IS 1
BP 75
EP 80
DI 10.1016/j.jhin.2017.10.022
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA GB9OG
UT WOS:000429402500012
PM 29128347
DA 2026-07-24
ER
PT J
AU Szkorupa, M
   Chudacek, J
   Klementová, O
   Neoral, C
   Stasek, M
AF Szkorupa, Marek
   Chudacek, Josef
   Klementova, Olga
   Neoral, Cestmir
   Stasek, Martin
TI Early simultaneous esophagopleural and bronchopleural fistula after
   right pneumonectomy
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE esophageal fistula; pneumonectomy; postoperative complication; lung
   neoplasm
ID EMPYEMA
AB Background: Esophagopleural and bronchopleural fistulas represent a rare, but life-threatening complication after lung resections, most often after a right pneumonectomy.
   Case study: A 64 years old woman was indicated for right pulmectomy for local recurrence of initially stage IIB lung cancer treated by lower lobectomy. On the postoperative day 34, an esophagopleurobronchial fistula occurred. Further course required thoracostomy with closure of the bronchial stump and vacuum-assisted closure therapy and two-phase esophagectomy with 6 weeks interval to the esophageal reconstruction. Patient represents 2 years of disease-free survival with good functional results.
   Conclusion: The therapy of esophagopleural and bronchopleural fistula is long-term and complicated, requiring a multidisciplinary approach and several basic principles must be adhered to the management including treatment of infection and prevention of sepsis, local treatment of the fistula and pleural empyema, and adequate ventilation and nutritive care.
C1 [Szkorupa, Marek; Chudacek, Josef; Neoral, Cestmir; Stasek, Martin] Palacky Univ Olomouc, Univ Hosp Olomouc, Fac Med & Dent, Dept Surg 1, Olomouc, Czech Republic.
   [Klementova, Olga] Palacky Univ Olomouc, Univ Hosp Olomouc, Fac Med & Dent, Dept Anesthesiol & Intens Care Med, IP Pavlova 6, Olomouc 77520, Czech Republic.
C3 Palacky University Olomouc; University Hospital Olomouc; Palacky
   University Olomouc; University Hospital Olomouc
RP Klementová, O (通讯作者)，Palacky Univ Olomouc, Univ Hosp Olomouc, Fac Med & Dent, Dept Anesthesiol & Intens Care Med, IP Pavlova 6, Olomouc 77520, Czech Republic.
EM saol@email.cz
RI /ABH-5345-2020; Stašek, Martin/AAB-4435-2020
OI Neoral, Čestmír/0000-0001-8912-8155; Stašek, Martin/0000-0002-1308-7390
CR Dosios T, 2005, DIS ESOPHAGUS, V18, P202, DOI 10.1111/j.1442-2050.2005.00472.x
   EVANS JP, 1972, THORAX, V27, P674, DOI 10.1136/thx.27.6.674
   Kim TH, 2014, J VASC INTERV RADIOL, V25, P623, DOI 10.1016/j.jvir.2013.12.015
   Klepetko W, 1999, EUR J CARDIO-THORAC, V15, P758, DOI 10.1016/S1010-7940(99)00089-5
   MASSARD G, 1994, ANN THORAC SURG, V58, P1437, DOI 10.1016/0003-4975(94)91930-5
   Renner C, 2010, ANN THORAC SURG, V89, P603, DOI 10.1016/j.athoracsur.2009.06.037
   SETHI GK, 1978, ANN THORAC SURG, V25, P74, DOI 10.1016/S0003-4975(10)63492-3
   Stolz A, 2010, COMPLICATIONS LUNG S
   Trigui W, 2002, ANN THORAC SURG, V74, P923, DOI 10.1016/S0003-4975(02)03673-1
   Zaheer S, 2006, ANN THORAC SURG, V82, P279, DOI 10.1016/j.athoracsur.2006.01.052
NR 10
TC 2
Z9 4
U1 0
U2 3
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PY 2018
VL 118
IS 1
BP 56
EP 58
DI 10.1080/00015458.2017.1300006
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GC9BD
UT WOS:000430091600010
PM 28460565
DA 2026-07-24
ER
PT J
AU Martinov, S
   Ortiz, S
AF Martinov, Sagi
   Ortiz, Soccoro
TI Ten-year follow-up of a case of necrotizing fasciitis successfully
   treated with negative-pressure wound therapy, dermal regeneration
   template application, and split- thickness skin autograft
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE Necrotising fasciitis; plastic surgery; negative pressure wound therapy;
   dermal template; skin-grafting
AB Introduction: Necrotizing fasciitis is a rapidly progressive and often fatal infection of the fasciae and subcutaneous tissues.
   Patient and methods: In this case report, we present the treatment of a 63-year-old patient suffering from diabetes mellitus, who was admitted to the emergency unit for severe right gluteal pain, which had begun 24 hours before admission. Cutaneous symptoms, oliguria, metabolic acidosis, acute renal failure, severe hypotension, and tachycardia occurred, and the patient was admitted to Intensive Care a few hours after initial admission. The patient underwent a debridement of gluteal, abdominal, lower-thoracic, and upper thigh regions. Biopsy of fascia lata confirmed the suspected diagnosis of necrotizing fasciitis. Treatment included prompt surgical debridement, negative-pressure wound therapy, and dermal regeneration template application with fibrin glue, and subsequent split-thickness skin autografting.
   Results: After 10 years, elasticity of the skin and limb mobility are comparable to that in non-injured areas, and the patient is pain free.
   Conclusion: In our opinion, this combination should be a treatment of choice for large wounds in the patients with NF with multiple comorbidities.
C1 [Martinov, Sagi; Ortiz, Soccoro] Free Univ Brussels, Brugmann Univ Hosp, Dept Plast & Reconstruct Surg, Brussels, Belgium.
C3 Universite Libre de Bruxelles
RP Martinov, S (通讯作者)，Free Univ Brussels, Brugmann Univ Hosp, Brussels, Belgium.
EM Sagimartinov@gmail.com
RI Martinov, Sagi/GPC-4434-2022
OI Martinov, Sagi/0000-0001-8191-950X
CR Al-Subhi FS, 2010, CAN J PLAST SURG, V18, P139, DOI 10.1177/229255031001800412
   Bento-Rodrigues J, 2013, ACTA MEDICA PORT, V26, P456
   Chiummariello S, 2012, G CHIR, V33, P358
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   Gardien KLM, 2016, CELL TRANSPLANT, V25, P437, DOI 10.3727/096368915X689569
   Goh T, 2014, BJS-BRIT J SURG, V101, pE119, DOI 10.1002/bjs.9371
   Hofmeister E, 2001, Am J Orthop (Belle Mead NJ), V30, P426
   Mizuguchi Y, 2015, J NIPPON MED SCH, V82, P290, DOI 10.1272/jnms.82.290
   Steinstraesser L, 2009, INT J LOW EXTR WOUND, V8, P28, DOI 10.1177/1534734609331991
   Wong CH, 2004, CRIT CARE MED, V32, P1535, DOI 10.1097/01.CCM.0000129486.35458.7D
NR 10
TC 0
Z9 1
U1 0
U2 0
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PY 2018
VL 118
IS 2
BP 120
EP 124
DI 10.1080/00015458.2017.1316618
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GC9BJ
UT WOS:000430092200009
PM 28438078
DA 2026-07-24
ER
PT J
AU Zoghbi, V
   Caskey, RC
   Dumon, KR
   Ballester, JMS
   Brooks, AD
   Morris, JB
   Dempsey, DT
AF Zoghbi, Veronica
   Caskey, Robert C.
   Dumon, Kristoffel R.
   Ballester, Jacqueline M. Soegaard
   Brooks, Ari D.
   Morris, Jon B.
   Dempsey, Daniel T.
TI "How To" Videos Improve Residents Performance of Essential Perioperative
   Electronic Medical Records and Clinical Tasks
SO JOURNAL OF SURGICAL EDUCATION
LA English
DT Article
DE electronic medical records; instructional films and videos; mobile
   applications; medical simulation; internship and residency
ID DECISION-SUPPORT; PRIMARY-CARE; INFORMATION; TECHNOLOGY; EDUCATION;
   IMPACT
AB OBJECTIVE: The ability to use electronic medical records (EMR) is an essential skill for surgical residents. However, frustration and anxiety surrounding EMR tasks may detract from clinical performance. We created a series of brief, 1-3 minutes "how to" videos demonstrating 7 key perioperative EMR tasks: booking OR cases, placing preprocedure orders, ordering negative-pressure wound dressing supplies, updating day-of-surgery history and physical notes, writing brief operative notes, discharging patients from the postanesthesia care unit, and checking vital signs. Additionally, we used "Cutting Insights"-a locally developed responsive mobile application for surgical trainee education-as a platform for providing interns with easy access to these videos. We hypothesized that exposure to these videos would lead to increased resident efficiency and confidence in performing essential perioperative tasks, ultimately leading to improved clinical performance.& para;& para;METHODS: Eleven surgery interns participated in this initiative. Before watching the "how to" videos, each intern was timed performing the aforementioned 7 key perioperative EMR tasks. They also underwent a simulated perioperative emergency requiring the performance of 3 of these EMR tasks in conjunction with 5 other required interventions (including notifying the chief resident, the anesthesia team, and the OR coordinator; and ordering fluid boluses, appropriate laboratories, and blood products). These simulations were scored on a scale from 0 to 8. The interns were then directed to watch the videos. Two days later, their times for performing the 7 tasks and their scores for a similar perioperative emergency simulation were once again recorded. Before and after watching the videos, participants were surveyed to assess their confidence in performing each EMR task using a 5-point Likert scale. We also elicited their opinions of the videos and web-based mobile application using a 5-point scale. Statistical analyses to assess for statistical significance (p <= 0.05) were conducted using paired t-test for parametric variables and a Wilcoxon matched-pair test for nonparametric variables.& para;& para;SETTING: Hospital of the University of Pennsylvania, Philadelphia, PA (a quaternary teaching hospital within the University of Pennsylvania Health System).
   & para;& para;PARTICIPANTS: Eleven out of 15 interns (12 entered and 11 completed the study) from our categorical and preliminary general surgery residency programs during the 2016 academic year.& para;& para;RESULTS: Before exposure to the brief "how to" videos, 6 of 11 interns were unable to complete all 7 EMR tasks; after exposure, all 11 interns were able to complete all 7 EMR tasks. Moreover, interns' times for each task improved following exposure. Interns self-reported improved confidence in booking an OR case (4 +/- 0.9 vs. 4.7 +/- 0.6, p = 0.05), ordering negative-pressure wound therapy supplies (3.1 +/- 1.6 vs. 4.5 +/- 0.7, p < 0.05), writing a brief operative note (3.7 +/- 1.2 vs. 4.6 +/- 0.7, p = 0.05), discharging patients from the postanesthesia care unit (3.3 +/- 1.0 vs. 4.4 +/- 0.8, p < 0.05), checking vital signs (2.5 +/- 1.4 vs. 4.5 +/- 0.8, p <= 0.01), and performing necessary EMR tasks during an emergency situation (2.4 +/- 0.8 vs. 4.6 +/- 0.7, p <= 0.0001). Participants also demonstrated a significant improvement in average clinical score on the emergency simulations (5.2 +/- 1.7 vs. 6.6 +/- 0.9, p < 0.05). Interns' opinions of the videos and the mobile phone application were favorable.& para;& para;CONCLUSIONS: In our group of 11 surgery interns, exposure to a series of short "how to" videos led to increased confidence and shortened times in performing 7 essential EMR tasks. Additionally, during a simulated perioperative emergency, EMR tasks were performed significantly faster. Clinical performance also improved significantly following exposure to the videos. This just-in-time educational intervention could improve workflow efficiency and clinical performance, both of which may ultimately enhance perioperative patient safety. (C) 2017 Published by Elsevier Inc. on behalf of the Association of Program Directors in Surgery
C1 [Zoghbi, Veronica; Dempsey, Daniel T.] Hosp Univ Penn, Dept Perioperat Serv, 3400 Spruce St, Philadelphia, PA 19104 USA.
   [Caskey, Robert C.; Dumon, Kristoffel R.] Univ Penn, Perelman Sch Med, Penn Med Simulat Ctr, Philadelphia, PA 19104 USA.
   [Dumon, Kristoffel R.; Brooks, Ari D.; Morris, Jon B.] Univ Penn, Dept Surg, Perelman Sch Med, Div Surg Educ, 3400 Spruce St,Silverstein Bldg,4th Floor, Philadelphia, PA 19104 USA.
   [Ballester, Jacqueline M. Soegaard; Dempsey, Daniel T.] Univ Penn, Dept Surg, Perelman Sch Med, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of Pennsylvania
RP Dumon, KR (通讯作者)，Univ Penn, Dept Surg, Perelman Sch Med, Div Surg Educ, 3400 Spruce St,Silverstein Bldg,4th Floor, Philadelphia, PA 19104 USA.
EM Kristoffel.Dumon@uphs.upenn.edu
OI Caskey, Robert/0009-0009-3143-5262; Brooks, Ari/0000-0003-4328-7307
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NR 20
TC 11
Z9 14
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1931-7204
EI 1878-7452
J9 J SURG EDUC
JI J. Surg. Educ.
PD MAR-APR
PY 2018
VL 75
IS 2
BP 489
EP 496
DI 10.1016/j.jsurg.2017.07.009
PG 8
WC Education, Scientific Disciplines; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Education & Educational Research; Surgery
GA GC9RP
UT WOS:000430136800033
PM 28801082
DA 2026-07-24
ER
PT J
AU Nalcacioglu, H
   Yakupoglu, YK
   Genc, G
   Belet, N
   Sensoy, SG
   Birinci, A
   Ozkaya, O
AF Nalcacioglu, Hulya
   Yakupoglu, Y. Kamil
   Genc, Gurkan
   Belet, Nursen
   Sensoy, Sema Gulnar
   Birinci, Asuman
   Ozkaya, Ozan
TI Disseminated fungal infection by Aureobasidium pullulans in a
   renal transplant recipient
SO PEDIATRIC TRANSPLANTATION
LA English
DT Article
DE Aureobasidium pullulans; fungal infection; pediatrics; renal transplant;
   vacuum-assisted closure therapy
ID VACUUM-ASSISTED CLOSURE; SUBCUTANEOUS MYCOSIS; WOUND MANAGEMENT;
   VAR.-MELANIGENUM; FUNGEMIA; PHEOHYPHOMYCOSIS
AB Renal transplant recipients are on long-term potent immunosuppressive therapy, which makes them highly vulnerable to opportunistic fungal infections. Dematiaceous, or dark-pigmented saprophytic fungi, are being increasingly seen as opportunistic pathogens of mycoses in immunosuppressed patients. One of these is Aureobasidium pullulans, which is a black yeast-like dematiaceous fungus found ubiquitously in the environment that can cause various opportunistic human infections. Most infections occur by traumatic inoculation, such as keratitis and cutaneous lesions; disseminated mycoses are very rare and occur only in severely immunocompromised patients. We report a case of disseminated fungal infection due to A.pullulans in a pediatric patient who underwent renal transplant. The use of voriconazole and vacuum-assisted closure along with surgical drainage most likely contributed to the patient's positive outcome.
C1 [Nalcacioglu, Hulya; Genc, Gurkan] Ondokuz Mayis Univ, Pediat Nephrol Dept, Fac Med, Kurupelit, Samsun, Turkey.
   [Yakupoglu, Y. Kamil] Ondokuz Mayis Univ, Urol Dept, Fac Med, Samsun, Turkey.
   [Belet, Nursen; Sensoy, Sema Gulnar] Ondokuz Mayis Univ, Pediat Infect Dis Dept, Fac Med, Samsun, Turkey.
   [Birinci, Asuman] Ondokuz Mayis Univ, Microbiol Dept, Fac Med, Samsun, Turkey.
   [Ozkaya, Ozan] Istinye Univ, LIV Hosp, Fac Med, Pediat Nephrol Dept, Istanbul, Turkey.
C3 Ondokuz Mayis University; Ondokuz Mayis University; Ondokuz Mayis
   University; Ondokuz Mayis University; Ankara Liv Hospital; Istinye
   University
RP Nalcacioglu, H (通讯作者)，Ondokuz Mayis Univ, Pediat Nephrol Dept, Fac Med, Kurupelit, Samsun, Turkey.
EM hulyanalcacoglu@hotmail.com
RI Nalcacioglu, Hulya/L-1713-2016; ozkaya, ozan/AAO-2136-2020; Yakupoglu,
   Yarkin/C-6414-2009; Birinci, Asuman/JUF-2423-2023
OI Nalcacioglu, Hulya/0000-0002-0686-9714; Yakupoglu, Yarkin
   Kamil/0000-0002-4764-0289
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 29
TC 5
Z9 10
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1397-3142
EI 1399-3046
J9 PEDIATR TRANSPLANT
JI Pediatr. Transplant.
PD MAY
PY 2018
VL 22
IS 3
AR e13152
DI 10.1111/petr.13152
PG 5
WC Pediatrics; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Transplantation
GA GD0IK
UT WOS:000430184300017
PM 29388304
DA 2026-07-24
ER
PT J
AU Noh, SM
   Ahn, JY
   Lee, JH
   Jung, HY
   AlGhamdi, Z
   Kim, HR
   Kim, YH
AF Noh, Soo Min
   Ahn, Ji Yong
   Lee, Jeong Hoon
   Jung, Hwoon-Yong
   AlGhamdi, Zeead
   Kim, Hyeong Ryul
   Kim, Yong-Hee
TI Endoscopic Vacuum-Assisted Closure Therapy in Patients with Anastomotic
   Leakage after Esophagectomy: A Single-Center Experience
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Article
ID MANAGEMENT; RESECTION; FISTULAS; DRAINAGE
AB Aim. To study the efficacy of E-VAC therapy for patients with anastomotic leakage after esophagectomy. Methods. Between January 2013 and April 2017, 12 patients underwent E-VAC therapy for the management of postoperative leakage. Their clinical features and endoscopic procedure details, therapy results, adverse events, and survival were investigated. Results. All 12 patients were male and the median age was 57 years (interquartile range 51.5-62.8 years). The reasons for esophageal surgery were esophageal cancer (83.3%), gastrointestinal stromal tumor (8.3%), and esophageal diverticulum (8.3%). Prior to E-VAC therapy, 6 patients had undergone failed primary surgical repair and the median duration from esophagectomy to leakage discovery was 13.5 days (IQR 6-207 days). The median duration of E-VAC therapy was 25 days (IQR 13.5-34.8 days) and the average sponge exchange rate was 2.7 times during the treatment period. After E-VAC therapy, 8 patients (66.7%) had complete leakage closure, 3 (25%) had a decreased leakage size, and 1 (8.3%) was unchanged. The three patients with a decreased leakage size after E-VAC therapy were treated with endoscopic and conservative management without further surgery. Conclusion. With proper patient selection, E-VAC therapy is a feasible and safe method for the treatment of anastomotic leakage after esophagectomy.
C1 [Noh, Soo Min] Univ Ulsan, Coll Med, Asan Med Ctr, Asan Digest Dis Res Inst,Dept Internal Med, Seoul, South Korea.
   [Ahn, Ji Yong; Lee, Jeong Hoon; Jung, Hwoon-Yong] Univ Ulsan, Coll Med, Asan Med Ctr, Asan Digest Dis Res Inst,Dept Gastroenterol, Seoul, South Korea.
   [AlGhamdi, Zeead; Kim, Hyeong Ryul; Kim, Yong-Hee] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Thorac & Cardiovasc Surg, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Ulsan; Asan
   Medical Center; University of Ulsan; Asan Medical Center
RP Ahn, JY (通讯作者)，Univ Ulsan, Coll Med, Asan Med Ctr, Asan Digest Dis Res Inst,Dept Gastroenterol, Seoul, South Korea.
EM ji110@hanmail.net
RI ALGHAMDI, ZEEAD/AFT-1593-2022; Ahn, Ji Yong/AGO-1695-2022
OI ALGHAMDI, ZEEAD/0000-0002-0096-4921; Ahn, Ji Yong/0000-0002-0030-3744; 
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
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   Weidenhagen R, 2010, ANN THORAC SURG, V90, P1674, DOI 10.1016/j.athoracsur.2010.07.007
NR 17
TC 28
Z9 31
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2018
VL 2018
AR 1697968
DI 10.1155/2018/1697968
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GD1OB
UT WOS:000430268500001
PM 29849581
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Svensson-Björk, R
   Hasselmann, J
   Acosta, S
AF Svensson-Bjork, Robert
   Hasselmann, Julien
   Acosta, Stefan
TI Evaluation of inguinal vascular surgical scars treated with closed
   incisional negative pressure wound therapy using three-dimensional
   digital imaging-A randomized controlled trial on bilateral incisions
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID QUALITY-OF-LIFE; ANTIBIOTIC-PROPHYLAXIS; INFLAMMATORY RESPONSE;
   ASSESSMENT SCALE; SITE INFECTION; LINEAR SCARS; SURGERY; PATIENT;
   METAANALYSIS; MANAGEMENT
AB Purpose of the investigation: Scar formation is an important, permanent surrogate marker for wound healing. The main aim of this randomized trial was to evaluate the effects of incisional negative pressure wound therapy (iNPWT) on scar formation in uncomplicated wound healing with 3-dimensional (3D) digital imaging. Basic procedures: Patients undergoing bilateral inguinal incisions after vascular surgery were randomized to receive iNPWT and standard dressing on separate sides. The incisional scars were documented at a median time of 808 days (range 394-1194) after surgery with 3D photography, which were objectively evaluated by two plastic surgeons using the Stony Brook scar evaluation scale (SBSES) and a 10-point graded numeric ranking scale (NRS10). Subjective evaluation was performed with the patient observer scar assessment scale (POSAS). Patients with surgical site infection or other wound complications were excluded to minimize bias. The p-values were calculated using McNemar's and Wilcoxon signed-rank test for paired nominal and paired continuous data, respectively. Main findings: Among 33 patients, 32 patients had undergone endovascular aortic repair (EVAR) and 31 patients had transverse inguinal incisions. Objective and subjective scar evaluation showed no difference between iNPWT and standard dressing. In objective scorings, 18.8 and 21.9% received the highest possible SBSES total score in the iNPWT and standard dressing groups, while 43.8 and 37.5% received the highest possible NRS10 score, respectively. The inter-rater reliability between the two assessors for SBSES total score and NRS10 showed an intra-class correlation (ICC) of 0.78 and 0.68 for NPWT and 0.70 and 0.77 for traditional dressing, respectively. Principal conclusion: The present randomized trial showed that iNPWT and standard dressings on closed transverse inguinal incisions after EVAR resulted in equal subtle scar formation. Objective scar evaluation with 3D images showed good inter-rater agreement.
C1 [Svensson-Bjork, Robert; Hasselmann, Julien; Acosta, Stefan] Lund Univ, Dept Clin Sci, Ruth Lundskogs G 10, S-20502 Malmo, Sweden.
   [Svensson-Bjork, Robert; Hasselmann, Julien; Acosta, Stefan] Skane Univ Hosp, Dept Cardiothorac & Vasc Surg, Vasc Ctr, Malmo, Sweden.
C3 Lund University; Lund University; Skane University Hospital
RP Acosta, S (通讯作者)，Lund Univ, Dept Clin Sci, Ruth Lundskogs G 10, S-20502 Malmo, Sweden.
EM Stefan.acosta@med.lu.se
RI Hasselmann, Julien/C-1586-2015; Acosta, Stefan/JAX-3225-2023;
   Hasselmann, Julien/C-1586-2015
OI Acosta, Stefan/0000-0002-3225-0798; Svensson-Björk,
   Robert/0000-0003-1907-9022; Hasselmann, Julien/0000-0003-4453-0292
FU Hulda Almroth Foundation
FX The Hulda Almroth Foundation.
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NR 40
TC 12
Z9 12
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN-FEB
PY 2018
VL 26
IS 1
BP 77
EP 86
DI 10.1111/wrr.12615
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA GD2CV
UT WOS:000430308600188
PM 29381241
DA 2026-07-24
ER
PT J
AU Yamaguchi, Y
   Yanagi, T
   Sato, K
   Yoshimoto, N
   Hirata, Y
   Ujiie, I
   Nishimura, M
   Natsuga, K
   Shiiya, C
   Tsukinaga, I
   Shimizu, H
AF Yamaguchi, Yasuyuki
   Yanagi, Teruki
   Sato, Kazumasa
   Yoshimoto, Norihiro
   Hirata, Yu
   Ujiie, Inkin
   Nishimura, Machiko
   Natsuga, Ken
   Shiiya, Chihiro
   Tsukinaga, Ichiro
   Shimizu, Hiroshi
TI Portable negative-pressure wound therapy for pyoderma gangrenosum:
   Report of two cases
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE negative-pressure wound therapy; PICO single use negative-pressure wound
   therapy system; portable negative-pressure wound therapy device;
   pyoderma gangrenosum; ulcer
ID CONTROLLED-TRIAL
AB Pyoderma gangrenosum is a chronic non-infectious neutrophilic dermatosis that causes undermining ulcers. Topical therapies for the deep ulcers of pyoderma gangrenosum have not been established. To investigate whether negative-pressure wound therapy is effective for a pyoderma gangrenosum ulcer, we used the PICO single use negative-pressure wound therapy system (Smith & Nephew, London, UK) for two pyoderma gangrenosum patients. In these cases, the ulcers decreased in size and necrolytic tissue was removed notably. Moreover, there were no secondary infections nor was there Koebner phenomena. Our cases suggest that portable negative-pressure wound therapy can be a treatment option for deep, intractable ulcers caused by pyoderma gangrenosum. Because portable negative-pressure wound therapy devices afford increased mobility to patients, they can give the patient a better quality of life than standard negative-pressure wound therapy systems do.
C1 [Yamaguchi, Yasuyuki; Yanagi, Teruki; Sato, Kazumasa; Yoshimoto, Norihiro; Hirata, Yu; Ujiie, Inkin; Nishimura, Machiko; Natsuga, Ken; Shimizu, Hiroshi] Hokkaido Univ, Grad Sch Med, Dept Dermatol, Sapporo, Hokkaido, Japan.
   [Shiiya, Chihiro; Tsukinaga, Ichiro] KKR Sapporo Med Ctr, Dept Dermatol, Sapporo, Hokkaido, Japan.
C3 Hokkaido University
RP Yanagi, T (通讯作者)，Hokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, North 15 West 7, Sapporo, Hokkaido 0608638, Japan.
EM yanagi@med.hokudai.ac.jp
RI ; Natsuga, Ken/H-4050-2012; Yanagi, Teruki/D-4222-2017; Shimizu,
   Hiroshi/A-5193-2012
OI Yamaguchi, Yasuyuki/0000-0003-1996-1584; Yanagi,
   Teruki/0000-0003-2196-7600; 
FU Grants-in-Aid for Scientific Research [17K16317] Funding Source: KAKEN
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NR 15
TC 6
Z9 6
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD APR
PY 2018
VL 45
IS 4
BP 483
EP 486
DI 10.1111/1346-8138.14180
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GD5KC
UT WOS:000430544900033
PM 29235669
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Waked, K
   Ballaux, P
   Goossens, D
   Cathenis, K
AF Waked, Karl
   Ballaux, Philippe
   Goossens, Dominique
   Cathenis, Koen
TI The "Two Bridges Technique' for sternal wound closure. The use of
   vacuum-assisted closure for the treatment of deep sternal wound defects:
   a centre-specific technique
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Deep sternal wound infection; Mediastinitis; Sternitis; VAC
ID POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY; RISK-FACTORS; INFECTION;
   THERAPY; ALGORITHM; SURVIVAL; FLAPS
AB The objective is to describe the Two Bridges Technique' (TBT), which has proven to be successful and has been the standard technique at our centre for vacuum-assisted closure (VAC) of post-sternotomy mediastinitis. An extensive literature search was performed in four databases to identify all published articles concerning VAC for post-sternotomy mediastinitis. Several VAC methods have been used; however, no article has described our specific technique. TBT consists of a two-bridges construction using two types of foam with different pore sizes, which ensures an equally divided negative pressure over the wound bed and stabilisation of the chest. This guarantees a continuous treatment of the sternal defect and prevents foam displacement. It maintains an airtight seal that prevents skin maceration and provides enough protection to avoid right ventricular rupture. The main advantage of TBT is the prevention of shifting or tilting of the foam during chest movements such as breathing or couching. Along with targeted antibiotic treatment, this alternative VAC technique can be an asset in the sometimes cumbersome treatment of post-sternotomy mediastinitis.
C1 [Waked, Karl; Ballaux, Philippe; Goossens, Dominique; Cathenis, Koen] AZ Maria Middelares Gent, Dept Cardiac Surg, Francois Spaestr 1, B-9090 Ghent, Belgium.
RP Waked, K (通讯作者)，AZ Maria Middelares Gent, Dept Cardiac Surg, Francois Spaestr 1, B-9090 Ghent, Belgium.
EM karl.waked@icloud.com
RI Ballaux, Philippe/JBI-9059-2023
OI Ballaux, Philippe/0009-0000-7979-6467; Waked, Karl/0000-0002-7409-5626
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NR 26
TC 4
Z9 4
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2018
VL 15
IS 2
BP 198
EP 204
DI 10.1111/iwj.12823
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GD6WI
UT WOS:000430649000004
PM 29430829
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Pujji, O
   Farrar, E
   Jeffery, S
AF Pujji, Ojas
   Farrar, Edmund
   Jeffery, Steven
TI Negative Pressure Wound Therapy to the Dura
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID DERMAL REGENERATION TEMPLATE
AB Negative-pressure wound therapy is historically contraindicated in patients with osteomyelitis or exposed dura. The authors present a case of a complex reconstruction of an infected full thickness scalp burn, where negative-pressure wound therapy was successfully used over the dura.
C1 [Pujji, Ojas] Univ Birmingham, Sch Med, Birmingham, W Midlands, England.
   [Farrar, Edmund] Queen Elizabeth Hosp, Burns & Plast Surg, MOD FY2, Birmingham, W Midlands, England.
   [Jeffery, Steven] Queen Elizabeth Hosp, Birmingham, W Midlands, England.
C3 University of Birmingham; University of Birmingham; University of
   Birmingham
RP Pujji, O (通讯作者)，Univ Birmingham, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England.
EM oxp225@bham.ac.uk; edmund.farrar@nhs.net; sjeffery@nhs.net
RI jeffery, steven/A-5207-2013
OI jeffery, steven/0000-0001-6587-5412
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   Zurovcik Danielle R, 2015, J Orthop Trauma, V29 Suppl 10, pS33, DOI [10.1097/bot.0000000000000410, 10.1097/BOT.0000000000000410]
NR 17
TC 2
Z9 2
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAY-JUN
PY 2018
VL 39
IS 3
BP 463
EP 467
DI 10.1097/BCR.0000000000000578
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA GD8AB
UT WOS:000430733400019
PM 28570314
DA 2026-07-24
ER
PT J
AU Wang, GQ
   Li, ZR
   Li, TT
   Wang, S
   Zhang, LH
   Zhang, LC
   Tang, PF
AF Wang, Guoqi
   Li, Zhirui
   Li, Tongtong
   Wang, Song
   Zhang, Lihai
   Zhang, Licheng
   Tang, Peifu
TI Negative-Pressure Wound Therapy in a Pseudomonas
   aeruginosa Infection Model
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID RABBIT EAR MODEL; STAPHYLOCOCCUS-AUREUS; BACTERIAL BIOFILMS; IN-VIVO;
   SKIN; VIRULENCE; ELASTASE; GROWTH; MECHANISMS; STRATEGIES
AB Background. Negative-pressure wound therapy (NPWT) is an effective strategy for the management of contaminated wounds, including those infected by Pseudomonas aeruginosa. We hypothesized that NPWT would reduce virulence factors as well as biofilm components and inhibit virulence-regulated gene expression in a model of P. aeruginosa wound infection. Methods. Wounds were created in anesthetized rabbits and P. aeruginosa was inoculated to the wound surface for 24h. Wounds were treated with either NPWT or a sterile gauze dressing. Virulence factors including exotoxin A, rhamnolipid, and elastase were quantified by the enzymelinked immunosorbent assay, orcinol, and elastin-Congo red methods, respectively. A biofilm component, eDNA, was quantified using a commercial kit. Virulence-regulated genes were determined by quantitative real-time polymerase chain reaction (RT-PCR). Biofilms were observed in vivo by staining with concanavalin A conjugated to Alexa Fluor (R) 647. Results. NPWT was more effective than the control treatment in reducing virulence factors and bacteria counts in vivo. A biofilm component, eDNA, was less abundant in the NPWT group. The results of the RT-PCR indicated that the expression levels of P. aeruginosa virulence-regulated genes and quorum-sensing population density-dependent systems were significantly inhibited by NPWT treatment. Conclusion. NPWT reduced bacteria counts, virulence factors, and eDNA in a P. aeruginosa wound infection model in vivo. These beneficial effects are likely to be related to the reduced expression of virulence-regulated genes and the drainage induced by NPWT treatment, These findings may help clinicians to obtain a better understanding of the mechanism of NPWT for the treatment of infected wounds.
C1 [Wang, Guoqi; Li, Zhirui; Zhang, Lihai; Zhang, Licheng; Tang, Peifu] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [Li, Tongtong] Tianjin Hosp, Dept Orthoped, 406 Jiefangnan Rd, Tianjin 300211, Peoples R China.
   [Wang, Song] Nankai Univ, Med Coll, Tianjin 300071, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Tianjin University;
   Nankai University
RP Zhang, LC; Tang, PF (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM zhanglcheng218@126.com; pftang301@163.com
RI ; Li, Zhirui/OJT-0490-2025
OI Tang, Peifu/0000-0003-4279-1704; 
FU National Natural Science Foundation of China [81472112]
FX This study was supported by the National Natural Science Foundation of
   China (Grant no. 81472112)
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NR 44
TC 19
Z9 20
U1 1
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2018
VL 2018
AR 9496183
DI 10.1155/2018/9496183
PG 11
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA GG0CI
UT WOS:000432345500001
PM 29862301
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Chan, T
   Bleszynski, MS
   Youssef, DS
   Segedi, M
   Chung, S
   Scudamore, CH
   Buczkowski, AK
AF Chan, T.
   Bleszynski, M. S.
   Youssef, D. S.
   Segedi, M.
   Chung, S.
   Scudamore, C. H.
   Buczkowski, A. K.
TI Open abdomen in liver transplantation
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID TEMPORARY ABDOMINAL CLOSURE; DAMAGE CONTROL; LAPAROTOMY; COMPLICATIONS;
   SURGERY; PATIENT
AB Introduction: Damage control laparotomy with vacuum assisted closure (VAC) is used for selective cases in trauma. In liver transplantation, VAC has also been applied for management of intra-operative hemorrhage. The primary objective was to evaluate pen-operative blood loss and blood product utilization in VAC compared to primary abdominal closure (PAC) at the index transplant operation.
   Methods: Retrospective review of all adults undergoing deceased donor liver transplantation (2007 2011) at a single center tertiary care institution.
   Results: 201 deceased donor liver transplantations were performed, with 167 PAC and 34 VAC cases. Intra-operative blood loss (4.4L vs 10.7L), cell saver return (1399 ml vs 3998 ml), FFP (7.6U vs 15.9U) and PLT requirements (8.5U vs 18.3U), were all significantly elevated in VAC compared to PAC. VAC patients had significantly increased RBC, FFP, PLT, and total volume requirements during initial ICU admission. 30 PAC cases required on demand laparotomy and most commonly for post-operative bleeding.
   Conclusion: In liver transplantation, application of VAC secondary to massive intra-operative exsanguination was safely utilized. Further evaluation is required to identify long-term morbidity and mortality. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Chan, T.; Bleszynski, M. S.; Youssef, D. S.; Segedi, M.; Chung, S.; Scudamore, C. H.; Buczkowski, A. K.] Univ British Columbia, Dept Gen Surg, Div Gen Surg, Vancouver, BC, Canada.
C3 University of British Columbia
RP Bleszynski, MS (通讯作者)，Univ British Columbia, Vancouver Gen Hosp, Fac Med, Dept Surg,Div Gen Surg, Rm 3100 Jim Pattison Pavill North, Vancouver, BC V5Z 1M9, Canada.
EM mbleszyn@gmail.com
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   Chiara O, 2016, J TRAUMA ACUTE CARE, V80, P173, DOI 10.1097/TA.0000000000000882
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NR 14
TC 4
Z9 5
U1 1
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2018
VL 215
IS 5
BP 782
EP 785
DI 10.1016/j.amjsurg.2017.12.012
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GG1TB
UT WOS:000432469100005
PM 29448990
DA 2026-07-24
ER
PT J
AU Liu, X
   Zhang, H
   Cen, SQ
   Huang, FG
AF Liu, Xi
   Zhang, Hui
   Cen, Shiqiang
   Huang, Fuguo
TI Negative pressure wound therapy versus conventional wound dressings in
   treatment of open fractures: A systematic review and meta-analysis
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Review
DE Meta-analysis; The negative pressure wound therapy (NPWT); Open
   fracture; Infection; Flap; Wound healing
ID TEMPORARY TREATMENT; TRAUMATIC WOUNDS; INFECTION; VACUUM; MANAGEMENT;
   CLOSURE; NPWT
AB Background: Though several systematic reviews concerned have been published, controversy still exists. The current systematic review was designed to clarify the detailed advantages and disadvantages of the negative pressure wound therapy (NPWT) in treatment of open fractures in comparison with the conventional wound dressings.
   Methods: A systematic search was performed in Pubmed, Cochrane Library, Embase, and Google Scholar for the published relevant clinical studies. Unpublished studies were searched in Clinicaltrials, ICTRP and ISRCTN. The outcome measures included presence of infection, wound healing process, length of the patient hospital stay, flap issues, frequency of amputation, and patient life quality.
   Results: In the 8 randomized controlled trials (RCTs) (421 patients) and the 6 retrospective cohort studies (488 patients), NPWT resulted in a significantly lower infection rate, significantly shorter wound coverage time, wound healing time and hospital stay length, and the lower amputation rate. However, no statistically significant difference was found in the need for flap surgery, the proportion of free flaps, the flap failure rate or the fracture non-union rate. Only 1 RCT was reported to have a higher physical component score of short form 36 in the infected patients.
   Conclusion: NPWT can significantly reduce the risk of infection in treatment of open fractures and accelerate their wound healing process. Some but not much evidence suggests that NPWT may possibly help reduce the severity of the limb injury and therefore provide a chance for the limb to avoid amputation. Use of NPWT in the flap area is probably safe, but should be carried out with caution. The advantage of NPWT over the conventional wound dressings still requires to be confirmed in the other aspects.
C1 [Liu, Xi; Zhang, Hui; Cen, Shiqiang; Huang, Fuguo] Sichuan Univ, West China Hosp, Dept Orthopaed Surg, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University
RP Zhang, H (通讯作者)，Sichuan Univ, West China Hosp, Dept Orthopaed Surg, Chengdu, Sichuan, Peoples R China.
EM 13540638434@163.com; zhanghuiwestchina@163.com; Ahsir7201@126.com;
   Huang-f-g@163.com
RI Zhang, Hui/OTH-2486-2025
CR [Anonymous], THESIS AM SOC PLAST
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NR 34
TC 84
Z9 106
U1 3
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD MAY
PY 2018
VL 53
BP 72
EP 79
DI 10.1016/j.ijsu.2018.02.064
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GG4GN
UT WOS:000432654400012
PM 29555530
DA 2026-07-24
ER
PT J
AU West, JM
   Jordan, SW
   Mendel, E
   Khan, SN
   Chandawarkar, RY
   Valerio, IL
AF West, Julie M.
   Jordan, Sumanas W.
   Mendel, Ehud
   Khan, Safdar N.
   Chandawarkar, Rajiv Y.
   Valerio, Ian L.
TI Instillation Negative Pressure Wound Therapy: An Effective Tool for
   Complex Spine Wounds
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure; VAC with instillation; debridement; infection
ID MANAGEMENT
AB Objective: Infection prevention in spinal surgeries involving implantation of hardware is of utmost priority. Furthermore, successful eradication of infection in hardware salvage is likewise critical in maintaining the long-term retention of the spinal hardware construct.
   Approach: We report a retrospective case series of three cases where the utilization of a VAC with instillation (VACi) in conjunction with surgical debridement aided in infection control and eradication for both preimplantation and hardware salvage spine patients.
   Results: Three patients were included. In case 1, VACi was utilized in conjunction with surgical debridement and IV antibiotics in the setting of acute preoperative infection to eradicate infection and enable necessary spinal hardware implementation. Cases 2 and 3 are representative of VACi for salvage of exposed spinal hardware in both the early and delayed infection presentation settings. In both cases, patients developed postoperative infections following spinal instrumentation VACi was utilized in conjunction with surgical debridement and IV antibiotics. Hardware removal was avoided in both cases. All three patients healed completely without residual evidence of infection.
   Innovation: VACi showed its effectiveness in timely infection eradication before spinal hardware instrumentation and with postoperative spine hardware salvage.
   Conclusion: This case series demonstrates that VACi can provide infection eradication both preoperatively in high-risk surgical sites, facilitating necessary hardware implementation and postoperatively in situations of hardware salvage.
C1 [West, Julie M.; Jordan, Sumanas W.; Chandawarkar, Rajiv Y.; Valerio, Ian L.] Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd,Suite 2100, Columbus, OH 43212 USA.
   [Mendel, Ehud] Ohio State Univ, Dept Neurosurg, Wexner Med Ctr, Columbus, OH 43210 USA.
   [Mendel, Ehud; Khan, Safdar N.; Chandawarkar, Rajiv Y.; Valerio, Ian L.] Ohio State Univ, Dept Orthoped Surg, Wexner Med Ctr, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University
RP West, JM (通讯作者)，Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd,Suite 2100, Columbus, OH 43212 USA.
EM Julie.West@osumc.edu
RI Valerio, Ian/F-9161-2017
CR Buck DW, 2014, GRABB SMITHS PLASTIC, P20
   Gage MJ, 2015, ORTHOP CLIN N AM, V46, P227, DOI 10.1016/j.ocl.2014.11.002
   Kapadia BH, 2016, LANCET, V387, P386, DOI 10.1016/S0140-6736(14)61798-0
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Lall RR, 2015, J CLIN NEUROSCI, V22, P238, DOI 10.1016/j.jocn.2014.07.010
   Lehner B, 2011, INT ORTHOP, V35, P1415, DOI 10.1007/s00264-011-1274-y
   McConoughey SJ, 2014, FUTURE MICROBIOL, V9, P987, DOI [10.2217/FMB.14.64, 10.2217/fmb.14.64]
   Negosanti L, 2012, DERMATOL THER, V25, P277, DOI 10.1111/j.1529-8019.2012.01451.x
   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
NR 9
TC 17
Z9 21
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD OCT
PY 2018
VL 7
IS 10
BP 333
EP 338
DI 10.1089/wound.2018.0793
EA MAY 2018
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GW9GX
UT WOS:000432714900001
PM 30374418
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU García, AF
   Sánchez, AI
   Gutiérrez, AJ
   Bayona, JG
   Naranjo, MP
   Lago, S
   Puyana, JC
AF Federico Garcia, Alberto
   Ignacio Sanchez, Alvaro
   Jose Gutierrez, Alvaro
   Gabriel Bayona, Juan
   Paula Naranjo, Maria
   Lago, Sebastian
   Carlos Puyana, Juan
TI Effect of abdominal negative-pressure wound therapy on the measurement
   of intra-abdominal pressure
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 18th European Congress of Trauma and Emergency Surgery
CY MAY 07-09, 2017
CL Bucharest, ROMANIA
DE Negative-pressure wound therapy; Intra-abdominal hypertension; Abdominal
   compartment syndrome; Critical care; Surgical decompression; Laparotomy
ID COMPARTMENT SYNDROME; CLOSURE TECHNIQUES; HYPERTENSION
AB Background: In critically ill surgical patients undergoing abdominal negative-pressure wound therapy (NPWT), it remains uncertain whether or not intra-abdominal pressure (IAP) measurements should be obtained when NPWT is activated. We aimed to determine agreement between IAP measured with and without NPWT.
   Methods: In this analytic cross-sectional study, critically ill surgical adults (>= 18 y) requiring abdominal NPWT for temporary abdominal closure after a damage control laparotomy were selected. Patients with urinary tract injuries or with pelvic packing were excluded. Paired IAP measures were performed in the same patient, with and without NPWT; two different operators performed the measures unaware of the other's result. Bland-Altman methods assessed the agreement between the two measures. Subgroup analyses (trauma and nontrauma) were performed.
   Results: There were 198 IAP measures (99 pairs) in 38 patients. Mean IAP with and without NPWT were 8.33 (standard deviation 4.01) and 8.65 (standard deviation 4.04), respectively. Mean IAP difference was -0.323 (95% confidence interval -0.748 to 0.101), and reference range for difference was -4.579 to 3.932 (P = 0.864). From 112 IAP measures (56 pairs) in 21 trauma patients, mean IAP difference was -0.268 (95% confidence interval -0.867 to 0.331), and reference range for the difference was -4.740 to 4.204 (P = 0.427).
   Conclusions: There was no statistically significant disagreement in IAP measures. IAP could be measured with or without NPWT. In critically ill surgical patients with abdominal NPWT for temporary abdominal closure, monitoring and management of IAP either with or without NPWT is recommended. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Federico Garcia, Alberto; Ignacio Sanchez, Alvaro] Fdn Valle Lili, Dept Surg, Cali, Colombia.
   [Ignacio Sanchez, Alvaro; Gabriel Bayona, Juan; Paula Naranjo, Maria] Fdn Valle Lili, Ctr Clin Res CIC, Cali, Colombia.
   [Jose Gutierrez, Alvaro; Lago, Sebastian] Univ ICESI, Sch Med, Cali, Colombia.
   [Carlos Puyana, Juan] Univ Pittsburgh, UPMC Presbyterian Hosp, Dept Surg, Pittsburgh, PA USA.
C3 Fundacion Valle del Lili; Fundacion Valle del Lili; Universidad ICESI;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; UPMC Presbyterian
RP Sánchez, AI (通讯作者)，Fdn Valle Lili, Carrera 98 18-49,Torre 7,Piso 3 CIC, Cali, Colombia.
EM alvaroisanchezortiz@gmail.com
RI ; Rueda Bayona, Juan Gabriel/AAQ-7604-2020; SANCHEZ ORTIZ,
   ALVARO/AFV-6810-2022
OI Naranjo Nates, María Paula/0009-0006-6735-9933; Puyana, Juan
   Carlos/0000-0003-4284-4693; Rueda Bayona, Juan
   Gabriel/0000-0003-3806-2058; SANCHEZ ORTIZ, ALVARO/0000-0001-6199-3358;
   García, Alberto Federico/0000-0002-4096-1434
FU Center of Clinical Research (CIC) at the Fundacion Valle del Lili
FX This work was supported by the Center of Clinical Research (CIC) at the
   Fundacion Valle del Lili.
CR Benninger E, 2008, J SURG RES, V144, P102, DOI 10.1016/j.jss.2007.02.021
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NR 14
TC 4
Z9 6
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD JUL
PY 2018
VL 227
BP 112
EP 118
DI 10.1016/j.jss.2018.02.030
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA GG9ZD
UT WOS:000433059300015
PM 29804842
DA 2026-07-24
ER
PT J
AU Lan, P
   Xie, LT
   Fang, WJ
   Pan, F
   Chen, CH
   Wu, JR
AF Lan Pin
   Xie Lutao
   Fang Weijun
   Pan Feng
   Chen Chaohui
   Wu Jianrong
TI Ulnar artery pseudoaneurysm and compartment syndrome formation after
   snake bite to the left forearm
SO CLINICAL TOXICOLOGY
LA English
DT Article
DE Pseudoaneurysm; compartment syndrome; snake bite; vacuum sealing
   drainage
ID ENVENOMATION
AB Objective: To report the outcome of a patient who developed pseudoaneurysms and compartment syndrome after a Deinagkistrodon acutus snakebite.
   Case report: A 61-year-old man, bitten by Deinagkistrodon acutus in his left forearm, came to the hospital eight hours after the bite. Despite the use of antivenom and supportive therapy, the patient developed compartment syndrome of the left forearm, the tissue pressure was elevated and fasciotomy was arranged. During the initial surgery, part of the necrotic tissues was removed. Moreover, two pseudoaneurysms of the ulnar artery were identified at the second debridement and the pseudoaneurysms were removed during this surgery. The patient went through a total of four surgeries, recovered and was eventually discharged from the hospital.
   Conclusion: A snake bite by Deinagkistrodon acutus may be accompanied by pseudoaneurysms and increased intracompartmental pressure.
C1 [Lan Pin; Xie Lutao; Fang Weijun; Pan Feng; Chen Chaohui; Wu Jianrong] Lishui Cent Hosp, Dept Emergency, Lishui City, Zhejiang, Peoples R China.
RP Xie, LT (通讯作者)，ZheJiang Univ, Lishui Hosp, Dept Emergency, Lishui City, Zhejiang, Peoples R China.
RI ; Fang, Weijun/PLR-5894-2026; Wu, Jian-Rong/ISV-3861-2023; Pan,
   Feng/IXN-2297-2023
OI lutao, Xie/0000-0001-5484-0601; 
CR Brys AK, 2015, PLAST RECONSTR SURG, V3, P396
   Bucaretchi F, 2010, CLIN TOXICOL, V48, P57, DOI 10.3109/15563650903356201
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NR 8
TC 10
Z9 12
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1556-3650
EI 1556-9519
J9 CLIN TOXICOL
JI Clin. Toxicol.
PY 2018
VL 56
IS 6
BP 436
EP 438
DI 10.1080/15563650.2017.1400042
PG 3
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA GH6GU
UT WOS:000433543000008
PM 29124975
DA 2026-07-24
ER
PT J
AU Geerdes-Fenge, H
   Pongratz, P
   Liese, J
   Reisinger, E
AF Geerdes-Fenge, H. F.
   Pongratz, P.
   Liese, J.
   Reisinger, E. C.
TI Vacuum-assisted closure therapy of paradoxical reaction in tuberculous
   lymphadenopathy caused by Mycobacterium africanum
SO INFECTION
LA English
DT Article
DE Tuberculosis; Cervical lymph node; Paradoxical reaction; Fistula;
   Vacuum-assisted closure; VAC; Mycobacterium africanum
ID HIV; MANAGEMENT
AB A 26-year-old HIV-negative male from Ghana was treated for cervical, intrathoracic and abdominal lymph node tuberculosis (TB) and tuberculous hepatitis. Penetration of the thoracic trachea by a mediastinal lymph node had caused bronchomucosal TB. Sputum culture grew M. africanum, sensitive to all first-line antituberculous drugs. Four weeks after the beginning of directly observed treatment with isoniazid, rifampin, pyrazinamide and ethambutol, the right cervical lymph node increased in size, liquefied and caused a spontaneous fistula. A biopsy of the necrotized lymph node revealed rare acid-fast bacilli with a positive PCR for Mycobacterium tuberculosis complex. After debridement, vacuum-assisted closure therapy was performed for 6 weeks. Five months after the beginning of antituberculous therapy, a second paradoxical reaction occurred, with painful swelling of two contralateral supraclavicular lymph nodes. Extirpation of one node yielded a positive PCR for M. tuberculosis complex; the culture was negative. Antituberculous treatment was continued, and additional treatment with oral prednisolone 20 mg daily for 1 month tapering over 10 weeks was introduced, resulting in a decrease in lymphadenopathy. Antituberculous treatment was continued for a total of 9 months. The outcome was favorable, no further lymphadenopathy occurred over the following 6 months.
C1 [Geerdes-Fenge, H. F.; Pongratz, P.; Reisinger, E. C.] Dept Trop Med & Infect Dis, Rostock, Germany.
   [Liese, J.] Rostock Univ, Med Ctr, Dept Oral & Maxillofacial Facial Plast Surg, Ernst Heydemann Str 6, D-18057 Rostock, Germany.
C3 University of Rostock
RP Geerdes-Fenge, H (通讯作者)，Dept Trop Med & Infect Dis, Rostock, Germany.
EM hilte.geerdes-fenge@med.uni-rostock.de
OI Geerdes-Fenge, Hilte/0000-0003-2839-0015
CR Barr DA, 2017, INT J TUBERC LUNG D, V21, P677, DOI 10.5588/ijtld.16.0927
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NR 20
TC 6
Z9 7
U1 0
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8126
EI 1439-0973
J9 INFECTION
JI Infection
PD JUN
PY 2018
VL 46
IS 3
BP 427
EP 430
DI 10.1007/s15010-017-1112-2
PG 4
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA GH8NC
UT WOS:000433924200018
PM 29330673
DA 2026-07-24
ER
PT J
AU Mencio, MA
   Ontiveros, E
   Burdick, JS
   Leeds, SG
AF Mencio, Marissa A.
   Ontiveros, Estrellita
   Burdick, James S.
   Leeds, Steven G.
TI Use of a novel technique to manage gastrointestinal leaks with
   endoluminal negative pressure: a single institution experience
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Esophageal perforation; Endoluminal vacuum therapy; Gastrointestinal
   leaks; Anastomotic leak; Bariatric complication; Sleeve leak
ID VACUUM-ASSISTED CLOSURE; SYSTEM E-VAC; ANASTOMOTIC INSUFFICIENCY; SLEEVE
   GASTRECTOMY; GASTRIC LEAKS; THERAPY; PERFORATIONS; ESOPHAGECTOMY;
   COMPLICATIONS; METAANALYSIS
AB Perforations and anastomotic leaks of the gastrointestinal tract are severe complications, which carry high morbidity and mortality and management of these is a multi-disciplinary challenge. The use of endoluminal vacuum (EVAC) therapy has recently proven to be a useful technique to manage these complications. We report our institution's experience with this novel technique in the chest, abdomen, and pelvis.
   This is a retrospective review of an IRB approved registry of all EVAC therapy patients from July 2013 to December 2016. A total of 55 patients were examined and 49 patients were eligible for inclusion: 15 esophageal, 21 gastric, 3 small bowel, and 10 colorectal defects. The primary endpoint was closure rate of the GI tract defect with EVAC therapy.
   Fifteen (100%) esophageal defects closed with EVAC therapy. Mean duration of therapy was 27 days consisting of an average of 6 endosponge changes every 4.8 days. Eighteen (86%) gastric defects closed with EVAC therapy. Mean duration of therapy was 38 days with a mean of 9 endosponge changes every 5.3 days. Three (100%) small bowel defects closed with EVAC therapy. Mean duration of therapy was 13.7 days with a mean of 2.7 endosponge changes every 4.4 days. Six (60%) colorectal defects closed with EVAC therapy. Mean duration of therapy was 23.2 days, consisting of a mean of 6 endosponge changes every 4.0 days. There were two deaths, which were not directly related to EVAC therapy and occurred outside the measured 30-day mortality.
   Our experience demonstrates that EVAC therapy is feasible and effective for the management of gastrointestinal perforations/leaks throughout the GI tract and can be considered as a safe alternative to surgical intervention in select cases.
C1 [Mencio, Marissa A.; Ontiveros, Estrellita; Leeds, Steven G.] Baylor Univ, Div Minimally Invas Surg, Med Ctr Dallas, 3500 Gaston Ave,1st Floor Roberts Hosp, Dallas, TX 75246 USA.
   [Burdick, James S.] Baylor Univ, Med Ctr Dallas, Dept Gastroenterol, Dallas, TX USA.
C3 Baylor University; Baylor University Medical Center; Baylor University
   Medical Center; Baylor University
RP Leeds, SG (通讯作者)，Baylor Univ, Div Minimally Invas Surg, Med Ctr Dallas, 3500 Gaston Ave,1st Floor Roberts Hosp, Dallas, TX 75246 USA.
EM Steven.Leeds@BSWHealth.org
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
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NR 27
TC 43
Z9 52
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD JUL
PY 2018
VL 32
IS 7
BP 3349
EP 3356
DI 10.1007/s00464-018-6055-x
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GI4SN
UT WOS:000434361600040
PM 29362911
DA 2026-07-24
ER
PT J
AU Tevanov, I
   Enescu, DM
   Carp, M
   Dusca, A
   Ladaru, A
   Ulici, A
AF Tevanov, Iulia
   Enescu, Dan Mircea
   Carp, Madalina
   Dusca, Andrei
   Ladaru, Alin
   Ulici, Alexandru
TI Negative pressure wound therapy in reconstructing extensive leg and foot
   soft tissue loss in a child: a case study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE children; open fracture; negative pressure wound therapy; soft tissue
   loss; traumatic injury
ID VACUUM-ASSISTED CLOSURE; III OPEN FRACTURES; MANAGEMENT; TIBIA;
   IRRIGATION; DEVICE
AB Open fractures of the leg with large loss of tissue require extensive reconstructive methods that can injure the donor area. The use of negative pressure wound therapy (NPWT) may minimise the impact of these reconstructive methods because of its capacity to create granulation tissue that will form a wound bed for the skin graft, thus reducing the volume of soft tissue defect and saving the donor region. This case study describes the effectiveness of NPWT in the treatment and reconstruction of an open fracture of the leg, with massive loss of soft tissue, associated with elastic intramedullary nailing in a 10-year-old female patient, who was a victim of a car accident. Clinical examination revealed a Gustilo-Anderson IIIB open fracture of the left leg, with the avulsion of the fifth toe, disarticulation of the fifth metatarsal bone, extensively damaged skin and subcutaneous tissue in the medium and distal third of the left leg and left foot. The bone was exposed in the distal part of the leg, external malleolus and left calcaneus. Profuse lavage, reduction of the tibial fracture and elastic intramedullary nailing, amputation of the fifth left toe, necrectomy and debridement of devitalised tissue were performed. NPWT was started, with the dressing changed every five days. After 55 days of using NPWT, granulation tissue covered the soft tissue defect and created a wound bed for the skin graft.
   NPWT helped the management of this open wound, achieving a wound bed for the skin graft, avoiding the use of complex reconstructive methods.
C1 [Tevanov, Iulia; Carp, Madalina; Dusca, Andrei; Ulici, Alexandru] Emergency Hosp Children Grigore Alexandrescu, Dept Pediat Orthoped Surg, Bucharest, Romania.
   [Enescu, Dan Mircea] Emergency Hosp Children Grigore Alexandrescu, Dept Plast & Reconstruct Surg, Bucharest, Romania.
   [Enescu, Dan Mircea; Ladaru, Alin; Ulici, Alexandru] Carol Davila Univ Med & Pharm, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Ulici, A (通讯作者)，Emergency Hosp Children Grigore Alexandrescu, Dept Pediat Orthoped Surg, Bucharest, Romania.; Ulici, A (通讯作者)，Carol Davila Univ Med & Pharm, Bucharest, Romania.
EM alexandruulici@yahoo.com
RI Carp, Madalina/AAP-5790-2021; Ulici, Alexandru/AAM-8799-2021
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NR 30
TC 8
Z9 8
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2018
VL 27
IS 6
SU S
BP S14
EP S19
DI 10.12968/jowc.2018.27.Sup6.S14
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GI7DH
UT WOS:000434662000003
PM 29883293
DA 2026-07-24
ER
PT J
AU Tahir, S
   Malone, M
   Hu, HH
   Deva, A
   Vickery, K
AF Tahir, Shamaila
   Malone, Matthew
   Hu, Honghua
   Deva, Anand
   Vickery, Karen
TI The Effect of Negative Pressure Wound Therapy with and without
   Instillation on Mature Biofilms In Vitro
SO MATERIALS
LA English
DT Article
DE biofilm; chronic wounds; instillation therapy; in vitro
ID BACTERIAL LOAD; INFECTIONS; BIOBURDEN
AB Background: To investigate the effect of negative pressure wound therapy (NPWT) with and without instillation (NPWTi) on in vitro mature biofilm. Methods: Mature biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown under shear (130 rpm) on polycarbonate coupons in a CDC biofilm reactor for 3 days. Coupons containing biofilms were placed in a sterile petri dish and sealed using NPWT or NPWTi. Coupons were exposed to treatment for 24 h with NPWT alone or with instillation of: Povidone iodine solution (PVP-I) (10% w/v equivalent to 1% w/v available iodine, BETADINE (R), Mundipharma, Singapore), surfactant based antimicrobial solution with polyhexamethylene biguanide (SBPHMB) (Prontosan (R), B Braun Medical, Melsungen, Germany), Gentamicin 1 mu g/mL (GM) (G1264 Sigma-Aldrich Pty Ltd., Castle Hill, Australia) Rifampicin 24 mu g/mL (RF) (R3501 Sigma-Aldrich Pty Ltd., Castle Hill, Australia) and NaCl 0.9% (Baxter, Deerfield, IL, USA). Bacterial cell viability and biofilm architecture pre-and post-treatment were assessed using colony forming units (cfu), Live/ Dead viability staining, confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM). Results: Significant reductions were obtained in S. aureus biofilm thickness (65%) and mass (47%) when treated with NPWTi as compared to NPWT only. NPWTi with instillation of SBPHMB, PVP-I and RF achieved between 2 and 8 log(10) reductions against S. aureus biofilm (p < 0.05-0.001). Conversely, PVP-I and SBMO achieved a 3.5 log(10) reduction against P. aeruginosa (p < 0.05). Conclusions: NPWT alters biofilm architecture by reducing biofilm thickness and mass, but this does not affect bacterial cell viability. NPWT with instillation of certain antimicrobials solutions may provide a further synergistic effect in reducing the number of viable biofilm microorganisms. Our in vitro model may be used for screening the effectiveness of antimicrobials used under instillation prior to animal or human studies.
C1 [Tahir, Shamaila; Hu, Honghua; Deva, Anand; Vickery, Karen] Macquarie Univ, Surg Infect Res Grp, Fac Med & Hlth Sci, Sydney, NSW 2109, Australia.
   [Malone, Matthew] Univ Western Sydney, Sch Med, Infect Dis & Microbiol, Sydney, NSW 2751, Australia.
   [Malone, Matthew] Ingham Inst Appl Med Res, Liverpool Diabet Collaborat Res Unit, Sydney, NSW 2170, Australia.
   [Malone, Matthew] Liverpool Hosp, High Risk Foot Serv, South West Sydney LHD, Sydney, NSW 2170, Australia.
C3 Macquarie University; Western Sydney University; Ingham Institute for
   Applied Medical Research; Liverpool Hospital
RP Tahir, S (通讯作者)，Macquarie Univ, Surg Infect Res Grp, Fac Med & Hlth Sci, Sydney, NSW 2109, Australia.
EM shamaila.tahir@students.mq.edu.au; matthew.malone@westernsydney.edu.au;
   helen.hu@mq.edu.au; anand.deva@mq.edu.au; karen.vickery@mq.edu.au
RI ; Hu, Honghua/AAG-2202-2021
OI Vickery, Karen/0000-0003-0998-1370; Hu, Honghua/0000-0002-3749-4089;
   Deva, Anand/0000-0002-0314-7177
FU Australian postgraduate award (APA); Macquarie University Vice
   Chancellor Innovation Fellowship
FX We would like to thank KCI Medical Pty. Ltd. for providing the V.A.C.(R)
   machines and consumables. Shamaila Tahir was in receipt of Australian
   postgraduate award (APA). A/Professor Vickery was in receipt of a
   Macquarie University Vice Chancellor Innovation Fellowship.
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
   Armstrong DG, 2017, NEW ENGL J MED, V376, P2367, DOI 10.1056/NEJMra1615439
   Burmolle M, 2010, FEMS IMMUNOL MED MIC, V59, P324, DOI 10.1111/j.1574-695X.2010.00714.x
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NR 19
TC 26
Z9 37
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1996-1944
J9 MATERIALS
JI Materials
PD MAY
PY 2018
VL 11
IS 5
AR 811
DI 10.3390/ma11050811
PG 11
WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy &
   Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering;
   Physics
GA GI7VY
UT WOS:000434711700161
PM 29772696
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Costa, ML
   Achten, J
   Bruce, J
   Tutton, E
   Petrou, S
   Lamb, SE
   Parsons, NR
AF Costa, Matthew L.
   Achten, Juul
   Bruce, Julie
   Tutton, Elizabeth
   Petrou, Stavros
   Lamb, Sarah E.
   Parsons, Nick R.
CA UK WOLLF Collaboration
TI Effect of Negative Pressure Wound Therapy vs Standard Wound Management
   on 12-Month Disability Among Adults With Severe Open Fracture of the
   Lower Limb The WOLLF Randomized Clinical Trial
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID ORTHOPEDIC TRAUMA; HEALTH; INFECTION; EUROQOL; SF-36
AB IMPORTANCE Open fractures of the lower limb occur when a broken bone penetrates the skin. There can be major complications from these fractures, which can be life-changing.
   OBJECTIVES To assess the disability, rate of deep infection, and quality of life in patients with severe open fracture of the lower limb treated with negative pressure wound therapy (NPWT) vs standard wound management after the first surgical debridement of the wound.
   DESIGN, SETTING, AND PARTICIPANTS Multicenter randomized trial performed in the UK Major Trauma Network, recruiting 460 patients aged 16 years or older with a severe open fracture of the lower limb from July 2012 through December 2015. Final outcome data were collected through November 2016. Exclusions were presentation more than 72 hours after injury and inability to complete questionnaires.
   INTERVENTIONS NPWT (n = 226) in which an open-cell solid foam or gauze was placed over the surface of the wound and connected to a suction pump, creating a partial vacuum over the dressing, vs standard dressings not involving application of negative pressure (n = 234). MAIN OUTCOMES AND MEASURES Disability Rating Index score (range, 0 [no disability] to 100 [completely disabled]) at 12 months was the primary outcome measure, with a minimal clinically important difference of 8 points. Secondary outcomes were complications including deep infection and quality of life (score ranged from 1 [best possible] to -0.59 [worst possible]; minimal clinically important difference, 0.08) collected at 3, 6, 9, and 12 months.
   RESULTS Among 460 patients who were randomized (mean age, 45.3 years; 74% men), 88% (374/427) of available study participants completed the trial. There were no statistically significant differences in the patients' Disability Rating Index score at 12 months (mean score, 45.5 in the NPWT group vs 42.4 in the standard dressing group; mean difference, -3.9 [95% CI, -8.9 to 1.2]; P = .13), in the number of deep surgical site infections (16 [7.1%] in the NPWT group vs 19 [8.1%] in the standard dressing group; difference, 1.0%[95% CI, -4.2% to 6.3%]; P = .64), or in quality of life between groups (difference in EuroQol 5-dimensions questionnaire, 0.02 [95% CI, -0.05 to 0.08]; Short Form-12 Physical Component Score, 0.5 [95% CI, -3.1 to 4.1] and Mental Health Component Score, -0.4 [95% CI, -2.2 to 1.4]).
   CONCLUSIONS AND RELEVANCE Among patients with severe open fracture of the lower limb, use of NPWT compared with standard wound dressing did not improve self-rated disability at 12 months. The findings do not support this treatment for severe open fractures.
C1 [Costa, Matthew L.; Bruce, Julie; Tutton, Elizabeth; Petrou, Stavros; Lamb, Sarah E.] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Gibbet Hill Campus, Coventry, W Midlands, England.
   [Costa, Matthew L.; Achten, Juul; Tutton, Elizabeth; Lamb, Sarah E.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford OX3 9DU, England.
   [Costa, Matthew L.] Univ Hosp Coventry & Warwickshire NHS Trust, Coventry, W Midlands, England.
   [Parsons, Nick R.] Univ Warwick, Warwick Med Sch, Stat & Epidemiol Unit, Gibbet Hill Campus, Coventry, W Midlands, England.
C3 University of Warwick; University of Oxford; University of Warwick;
   University of Warwick
RP Costa, ML (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford OX3 9DU, England.
EM Matthew.costa@ndorms.ox.ac.uk
RI Parsons, Nick/AAA-8713-2019; Petrou, Stavros/ABD-8323-2021; Bruce,
   Julie/G-7588-2014; Achten, Juul/KUD-8515-2024
OI Parsons, Nick/0000-0001-9975-888X; Petrou, Stavros/0000-0003-3121-6050;
   Tutton, Elizabeth/0000-0003-3973-360X; Costa,
   Matthew/0000-0003-3644-1388; Lamb, Sarah/0000-0003-4349-7195; Bruce,
   Julie/0000-0002-8462-7999; Achten, Juul/0000-0002-8857-5743
FU UK NIHR HTA Programme [10/57/20]; NIHR Oxford Biomedical Research
   Centre; NIHR Collaboration for Leadership in Applied Health Research and
   Care in Oxford; Smith Nephew; KCI Medical; Economic and Social Research
   Council [1499410] Funding Source: researchfish; Medical Research Council
   [G0501681, G0700452] Funding Source: researchfish; National Institute
   for Health Research [NF-SI-0616-10103, 10/57/20] Funding Source:
   researchfish; MRC [G0501681, G0700452] Funding Source: UKRI
FX This project was funded by the UK NIHR HTA Programme (project No.
   10/57/20) and was supported by the NIHR Oxford Biomedical Research
   Centre and the NIHR Collaboration for Leadership in Applied Health
   Research and Care in Oxford. The 2 main commercial entities (Smith &
   Nephew and KCI Medical) in this sector funded the excess treatment costs
   of the negative pressure wound therapy dressings but had no part in the
   design, conduct, or reporting of the trial.
CR Achten J, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-009087
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NR 24
TC 133
Z9 160
U1 0
U2 11
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 12
PY 2018
VL 319
IS 22
BP 2280
EP 2288
DI 10.1001/jama.2018.6452
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GJ2UP
UT WOS:000435129300014
PM 29896626
OA Green Accepted, Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Jain, NS
   Horn, CB
   Centeno, AAC
   Ilahi, ON
   Mazuski, JE
   Bocchichio, GV
   Punch, LJ
AF Jain, Nirbhay S.
   Horn, Christopher B.
   Centeno, Adrian A. Coleoglou
   Ilahi, Obeid N.
   Mazuski, John E.
   Bocchichio, Grant V.
   Punch, Laurie J.
TI Femoral Osteomyelitis Caused by Cladophialophora in a Patient
   without Known Immunocompromise
SO SURGICAL INFECTIONS
LA English
DT Article
DE chronic osteomyelitis; fungal infection; girdlestone arthroplasty;
   osteomyelitis
ID PRESSURE WOUND THERAPY
AB Background: Chronic osteomyelitis associated with a stage IV decubitus ulcer is a challenging condition to manage, characterized by frequent relapses and need for long-term anti-microbial therapy. Although gram-positive cocci are the most common causes, fungal infections have been reported, usually in immunocompromised hosts. We present a case of Cladophialophora osteomyelitis in a patient without known immunocompromised that was managed with a Girdlestone pseudoarthroplasty. Case Report: A 70-year-old male presented to our emergency room with fever, right hip pain, and purulent drainage from a right greater trochanter stage IV decubitus ulcer. His medical history was significant for T10 paraplegia secondary to spinal ependymomas and multiple spinal procedures, as well as significant recent weight loss. Past operations included multiple spinal procedures and repair of a right intertrochanteric femoral fracture with a plate and lateral compression screws. This led to post-operative decubitus ulcer formation over the right greater trochanter, requiring a gracilis flap. The flap remained intact for three years, then re-ulcerated. He subsequently developed femoral head osteomyelitis. To facilitate the treatment, the hardware was removed three weeks prior to presentation. With evidence of worsening osteomyelitis and a new soft-tissue infection, a Girdlestone procedure was performed. Intra-operatively, he was noted to have a pathological intertrochanteric fracture. Soft-tissue cultures yielded Pseudomonas aeruginosa; bone cultures grew Streptococcus dysgalactiae and Cladophialophora spp. Post-operatively, his wound was managed with negative pressure wound therapy with instillation and dwell (NPWTi-d). Delayed primary closure over a drain and topical negative pressure was done four days later. His course was uneventful, and he was discharged six days later. At his four-month follow-up, the wound was completely healed. Conclusion: Invasive fungal infections are rare in immunocompetent individuals. Cladophialophora osteomyelitis has been found in immunocompromised individuals with concomitant cerebral abscesses. To our knowledge, this is the first case of osteomyelitis without previously known immunocompromise.
C1 [Jain, Nirbhay S.] Washington Univ, Sch Med, St Louis, MO USA.
   [Horn, Christopher B.; Centeno, Adrian A. Coleoglou; Ilahi, Obeid N.; Mazuski, John E.; Bocchichio, Grant V.; Punch, Laurie J.] Washington Univ, Dept Surg, St Louis, MO USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Centeno, AAC (通讯作者)，Washington Univ, Sch Med, Dept Surg, Campus Box 8109,660 South Euclid Ave, St Louis, MO 63110 USA.
EM coleogloua@wustl.edu
OI Horn, Christopher/0000-0003-0717-3601; Ilahi, Obeid/0000-0003-0719-2554
CR Bariteau JT, 2014, J AM ACAD ORTHOP SUR, V22, P390, DOI 10.5435/JAAOS-22-06-390
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NR 12
TC 1
Z9 1
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD JUL
PY 2018
VL 19
IS 5
BP 544
EP 547
DI 10.1089/sur.2018.046
EA JUN 2018
PG 4
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA GL0WY
UT WOS:000435154400001
PM 29893620
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Masters, JPM
   Achten, J
   Cook, J
   Dritsaki, M
   Sansom, L
   Costa, ML
AF Masters, James P. M.
   Achten, Juul
   Cook, Jonathan
   Dritsaki, Melina
   Sansom, Lucy
   Costa, Matthew L.
TI Randomised controlled feasibility trial of standard wound management
   versus negative-pressure wound therapy in the treatment of adult
   patients having surgical incisions for hip fractures
SO BMJ OPEN
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SITE INFECTION; RISK-FACTORS; SURVEILLANCE;
   MORTALITY
AB Introduction Deep wound infection is a catastrophic complication after hip fracture surgery. However, current understanding of infection rates in this population is limited. Many technologies such as incisional negative-pressure wound therapy (NPWT) show promise in reducing the rate of infection. This trial is a feasibility study looking to establish a value estimated with a greater precision of the rate of deep infection after hip fracture treatment in patients treated with NPWT versus standard dressing following hip fracture surgery.
   Methods and analysis A randomised controlled trial of 464 patients will be run across multiple centres. It is embedded in the World Hip Trauma Evaluation cohort study. Any patient over the age of 65 years having surgery for hip fracture is eligible unless they are being treated with percutaneous screw fixation. A web-based randomisation sequence will stratify patients by centre. Patients will be allocated to either NPWT or standard care on a 1: 1 basis. The primary outcome measure is the Centre for Disease Control definition of deep infection at 30 days. Follow-up at 4 months will also assess deep infection and the core outcome dataset for hip fractures. This includes health-related quality of life (EQ-5D-5L), mobility, mortality and late complications such as further surgery. The primary analysis will be intention to treat.
   Ethics and dissemination Oxford C Research Ethics Committee granted ethical approval on 28/04/2017, 17/SC/0207. The results of this study will be reported in a peer-reviewed publication and inform the design of a future full-scale trial.
C1 [Masters, James P. M.; Achten, Juul; Sansom, Lucy; Costa, Matthew L.] Univ Oxford, Oxford Trauma, NDORMS, Oxford, England.
   [Cook, Jonathan] Univ Oxford, Ctr Stat Med, NDORMS, Oxford, England.
   [Dritsaki, Melina] Univ Oxford, Oxford Clin Trial Unit, NDORMS, Oxford, England.
C3 University of Oxford; University of Oxford; University of Oxford
RP Masters, JPM (通讯作者)，Univ Oxford, Oxford Trauma, NDORMS, Oxford, England.
EM james.masters@ndorms.ox.ac.uk
RI Masters, James/U-8764-2019; Cook, Jonathan/D-3648-2015; Achten,
   Juul/KUD-8515-2024
OI Masters, James/0000-0001-9663-8858; Cook, Jonathan/0000-0002-4156-6989;
   Achten, Juul/0000-0002-8857-5743; Costa, Matthew/0000-0003-3644-1388
FU Royal College of Surgeons of England; Dunhill Medical Trust
   [DMT/RCS605]; National Institute for Health Research (NIHR) Oxford
   Biomedical Research Centre; MRC [MR/K025643/1] Funding Source: UKRI;
   Medical Research Council [MR/K025643/1] Funding Source: researchfish;
   National Institute for Health Research [14/199/14, NF-SI-0514-10114]
   Funding Source: researchfish; The Dunhill Medical Trust [DMT/RCS605]
   Funding Source: researchfish
FX The study is funded by the Royal College of Surgeons of England and The
   Dunhill Medical Trust [DMT/RCS605]. It is supported by the National
   Institute for Health Research (NIHR) Oxford Biomedical Research Centre.
   Excess treatment costs for the negative pressure wound therapy arm of
   the study are met by Smith and Nephew.
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   Wilson J, 2008, INFECT CONT HOSP EP, V29, P219, DOI 10.1086/527511
NR 28
TC 13
Z9 14
U1 0
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD APR
PY 2018
VL 8
IS 4
AR e020632
DI 10.1136/bmjopen-2017-020632
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GJ3FT
UT WOS:000435176700181
PM 29654039
OA Green Submitted, Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Pontell, ME
   Saad, N
   Winters, BS
   Daniel, JN
   Saad, A
AF Pontell, Matthew E.
   Saad, Noah
   Winters, Brian S.
   Daniel, Joseph N.
   Saad, Adam
TI Reverse Sural Adipofascial Flaps with Acellular Dermal Matrix and
   Negative-Pressure Wound Therapy
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE acellular dermal matrix; lower-extremity wounds; negative-pressure wound
   therapy; reverse sural adipofascial flap; split-thickness skin graft;
   surgical flap
ID SOFT-TISSUE DEFECTS; FASCIOCUTANEOUS FLAP; ISLAND FLAP;
   FASCIOSUBCUTANEOUS FLAP; LEG; FOOT; ANKLE
AB The reverse sural adipofascial flap (RSAF) is used to reconstruct challenging wounds of the foot and ankle. It offers several advantages over the traditional reverse sural flap, including less venous congestion. To complete the reconstruction, split-thickness skin grafting (STSG) may be done immediately or in a delayed fashion; however, both scenarios result in suboptimal take rates and prolonged healing. An acellular dermal matrix (ADM; Integra; Ethicon Inc, Somerville, New Jersey) and negative-pressure wound therapy (NPWT) combined with RSAF followed by delayed STSG may decrease wound healing time.
   In this study, 8 patients underwent reconstruction of lower-extremity wounds with RSAF. Four patients underwent RSAF with immediate STSG, and 4 underwent RSAF with placement of the ADM and a vacuum-assisted closure device, with STSG at a later date. The 4 patients who underwent RSAF and immediate STSG had an average time to heal of 141.2 days, and 2 patients required reoperation. The 4 patients who underwent RSAF with an ADM and NPWT had an average time to heal of 104.5 days, and 1 patient required reoperation. Average time until STSG was 41.5 days. The latter group demonstrated a reduction in time to heal by an average of 36.7 days, or 25%. All 8 patients achieved successful wound closure.
   The RSAF is a durable option for complex lower-extremity reconstruction. Interim placement of ADM and NPWT may increase STSG take rates. Using this technique in conjunction with RSAF may decrease the overall healing time compared with RSAF with immediate STSG.
C1 [Pontell, Matthew E.; Saad, Adam] Drexel Univ, Coll Med, Dept Surg, Philadelphia, PA 19104 USA.
   [Saad, Noah] Univ Maryland, Dept Surg, Baltimore, MD 21201 USA.
   [Winters, Brian S.] Rothman Inst, Egg Harbor Township, NJ USA.
   [Winters, Brian S.] Thomas Jefferson Univ, Orthoped Surg, Philadelphia, PA 19107 USA.
   [Daniel, Joseph N.] Rothman Inst Orthoped, Egg Harbor Township, NJ USA.
   [Daniel, Joseph N.] Rowan Univ, Sch Med, Stratford, NJ USA.
   [Saad, Adam] Inst Adv Reconstruct, Plast Surg Ctr, Egg Harbor Township, NJ USA.
C3 Drexel University; University System of Maryland; University of Maryland
   Baltimore; Rothman Institute; Thomas Jefferson University; Rothman
   Institute; Rowan University
RP Pontell, ME (通讯作者)，Drexel Univ, Coll Med, Dept Surg, Philadelphia, PA 19104 USA.
OI Saad, Adam/0000-0003-3377-9877
CR AMARANTE J, 1986, BRIT J PLAST SURG, V39, P338, DOI 10.1016/0007-1226(86)90043-3
   Bocchi A, 2000, ANN PLAS SURG, V45, P284, DOI 10.1097/00000637-200045030-00011
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NR 18
TC 10
Z9 14
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2018
VL 31
IS 1
BP 612
EP 617
DI 10.1097/01.ASW.0000527290.81581.af
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA GJ3IE
UT WOS:000435185000007
PM 29240590
DA 2026-07-24
ER
PT J
AU Fujii, Y
   Tajima, Y
   Kaji, S
   Kishi, T
   Miyazaki, Y
   Taniura, T
   Hirahara, N
AF Fujii, Yusuke
   Tajima, Yoshitsugu
   Kaji, Shunsuke
   Kishi, Takashi
   Miyazaki, Yoshiko
   Taniura, Takahito
   Hirahara, Noriyuki
TI Complete abdominal wound and anastomotic leak with diffuse peritonitis
   closure achieved by an abdominal vacuum sealing drainage in a critical
   ill patient: a case report
SO BMC SURGERY
LA English
DT Article
DE Anastomotic leakage; Peritonitis; Wound dehiscence; Negative pressure
   wound therapy
ID ENTEROCUTANEOUS FISTULAS; ASSISTED CLOSURE; MANAGEMENT
AB Background: Negative pressure wound therapy (NPWT) is a widely accepted technique to treat local infectious wounds of the skin, subcutaneous tissue, fascia, or muscle. Recently, several reports describing the efficacy of NPWT for various types of fistulas and anastomotic leaks have been published. We herein describe a patient with an open abdominal wound due to colonic anastomotic leakage and diffuse peritonitis, in whom abdominal vacuum sealing (AVS) as a modified NPWT was useful for the management of this complex wound.
   Case presentation: A 32-year-old man was admitted to our hospital with late presenting traumatic diaphragmatic hernia and strangulated ileum complicated by necrosis of the ileum and transverse colon. He had a history of cervical spinal cord injury due to suicide attempt 14 years earlier and, as a result of cervical spinal cord injury, he was paralyzed in the lower body. The patient underwent an urgent hernia repair and bowel resection. Postoperatively, he developed severe septic shock On postoperative day (POD) 6, wound dehiscence due to colonic anastomotic leakage with diffuse peritonitis was diagnosed, but he was unable to undergo re-operation because of refractory severe septic shock combined with neurogenic shock due to the cervical cord injury. The patient was treated with AVS therapy. He gradually recovered from septic shock, and the anastomotic leakage healed after a 2-month period. The wound dehiscence was also reduced. The patient resumed oral intake on POD 112 and was discharged on POD 190.
   Conclusions: Although surgical repair would be the best method for the treatment of diffuse peritonitis due to gastrointestinal perforation or anastomotic leakage, our case suggests that AVS with 'conventional' drainage is a treatment of choice for open abdominal wounds even in the presence of diffuse peritonitis caused by intestinal anastomotic leakage, especially in patients with poor general medical condition.
C1 [Fujii, Yusuke; Tajima, Yoshitsugu; Kaji, Shunsuke; Kishi, Takashi; Miyazaki, Yoshiko; Taniura, Takahito; Hirahara, Noriyuki] Shimane Univ, Fac Med, Dept Digest & Gen Surg, 89-1 Enyacho, Izumo, Shimane 6938501, Japan.
C3 Shimane University
RP Fujii, Y (通讯作者)，Shimane Univ, Fac Med, Dept Digest & Gen Surg, 89-1 Enyacho, Izumo, Shimane 6938501, Japan.
EM yuusuke@med.shimane-u.ac.jp
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banasiewicz T, 2011, VIDEOSURGERY MINIINV, V6, P155, DOI 10.5114/wiitm.2011.24694
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NR 14
TC 4
Z9 5
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD JUN 15
PY 2018
VL 18
AR 41
DI 10.1186/s12893-018-0375-6
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GJ5GN
UT WOS:000435409600001
PM 29907107
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Warner, HJ
   Wagner, WD
AF Warner, Harleigh J.
   Wagner, William D.
TI Fabrication of biodegradable foams for deep tissue negative pressure
   treatments
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE polyester; polycaprolactone; poly(lactic-co-glycolic acid); foams;
   negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; DRUG-DELIVERY; WOUND CONTROL; DEGRADATION;
   INJURY
AB Devices for negative pressure wound therapy (NPWT) rely on compressible foams operating at the tissue-device interface. Clinically used foams are nonabsorbable and if used on deep wounds or left in place for an extended period of time, excessive cell ingrowth and formation of granulation tissue into the foam may require a surgical procedure to remove the foam. Foams with fast degradation and with low immunogenicity and fibrotic response are required. Foams composed of combinations of poly(lactide-co-glycolide) (PLGA), poly(lactide-co-caprolactone) (PLCL), and polycaprolactone (PCL) were created by combined salt leaching and solvent displacement protocols. In vitro and in vivo degradation studies and mechanical properties of foams were evaluated and compared to clinically used poly(vinyl alcohol) (PVA) foam and PCL foams. Foams composed of PLGA (50:50 lactide:glycolide) of low molecular weight blended with PCL maintained mechanical properties and degraded significantly after 21 days of subcutaneous implantation in rats. The most ideal formulations for use in NPWT were identified as copolymeric PLGA (M-n 3000 Da) at a lactide:glycolide ratio of 50:50 combined with PCL at either a 75:25 or 50:50 ratio, and copolymeric PLGA (M-n 7500 Da) at a lactide:glycolide ratio of 50:50 combined with PCL at a 50:50 ratio. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1998-2007, 2018.
C1 [Warner, Harleigh J.; Wagner, William D.] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27103 USA.
   [Warner, Harleigh J.; Wagner, William D.] Wake Forest Univ, Bowman Gray Sch Med, Dept Biomed Engn, Winston Salem, NC 27109 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University; Wake Forest Baptist Medical Center
RP Wagner, WD (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27103 USA.; Wagner, WD (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Biomed Engn, Winston Salem, NC 27109 USA.
EM wwagner@wakehealth.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2012, NEUROSURGERY, V70, P1281, DOI 10.1227/NEU.0b013e3182446760
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NR 23
TC 4
Z9 5
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD JUL
PY 2018
VL 106
IS 5
BP 1998
EP 2007
DI 10.1002/jbm.b.34007
PG 10
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA GJ5SU
UT WOS:000435443500036
PM 29031009
DA 2026-07-24
ER
PT J
AU Achten, J
   Vadher, K
   Bruce, J
   Nanchahal, J
   Spoors, L
   Masters, JP
   Dutton, S
   Madan, J
   Costa, ML
AF Achten, Juul
   Vadher, Karan
   Bruce, Julie
   Nanchahal, Jagdeep
   Spoors, Louise
   Masters, James P.
   Dutton, Susan
   Madan, Jason
   Costa, Matthew L.
TI Standard wound management versus negative-pressure wound therapy in the
   treatment of adult patients having surgical incisions for major trauma
   to the lower limb - a two-arm parallel group superiority randomised
   controlled trial: protocol for Wound Healing in Surgery for Trauma
   (WHIST)
SO BMJ OPEN
LA English
DT Article
ID TIBIAL PLAFOND; HEALTH; FRACTURES; EUROQOL; PAIN
AB Introduction Patients with dosed high-energy injuries associated with major trauma have surprisingly high rates of surgical site infection in incisions created during fracture fixation. One factor that may reduce the risk of surgical site infection is the type of dressing applied over the dosed surgical incision. In this multicentre randomised clinical trial, negative-pressure wound therapy will be compared with standard dressings with outcomes of deep infection, quality of life, pain and disability.
   Methods and analysis Adult patients presenting to hospital within 72 hours of sustaining major trauma, requiring a surgical incision to treat a fractured lower limb, are eligible for inclusion. Randomisation, stratified by trial centre, open/closed fracture at presentation and Injury Severity Score (ISS) <= 15 versus ISS >= 16 will be administered via a secure web-based service using minimisation. The random allocation will be to either standard wound management or negative-pressure wound therapy. Trial participants will usually have clinical followup at the local fracture clinic for a minimum of 6 months, as per standard National Health Service practice. Diagnosis of deep infection will be recorded at 30 days. Functional, pain and quality of life outcome data will be collected using the Disability Rating Index, Douleur Neuropathique Questionnaire and Eurogol - 5 Dimension - 5 level (EQ-5D-5L) questionnaires at 3 months and 6 months postinjury. Further data will be captured on resource use and any late postoperative complications. Longer term outcomes will be assessed annually for 5 years and reported separately.
   Ethics and dissemination National Research Ethics Committee approved this study on 16 February 2016 16/WM/0006. The National Institute for Health Research Health Technology Assessment monograph and a manuscript to a peer-reviewed journal will be submitted on completion of this trial. The results of this trial will inform clinical practice on the clinical and cost-effectiveness of the treatment of this injury.
C1 [Achten, Juul; Spoors, Louise; Masters, James P.; Costa, Matthew L.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
   [Vadher, Karan; Dutton, Susan] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Clin Trials Res Unit, Ctr Stat Med, Oxford, England.
   [Bruce, Julie; Madan, Jason] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Coventry, W Midlands, England.
   [Nanchahal, Jagdeep] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
C3 University of Oxford; University of Oxford; University of Warwick;
   University of Oxford; Kennedy Institute for Rheumatology
RP Costa, ML (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
EM matthew.costa@ndorms.ox.ac.uk
RI Achten, Juul/KUD-8515-2024; Bruce, Julie/G-7588-2014; Masters,
   James/U-8764-2019
OI Achten, Juul/0000-0002-8857-5743; Dutton, Susan/0000-0003-4573-5257;
   Bruce, Julie/0000-0002-8462-7999; Costa, Matthew/0000-0003-3644-1388;
   Masters, James/0000-0001-9663-8858; Nanchahal,
   Jagdeep/0000-0002-9579-9411
FU UK National Institute for Health Research Health Technology Assessment
   (HTA) Programme [14/199/14]; National Institute for Health Research
   (NIHR) Oxford Biomedical Research Centre; National Institute for Health
   Research [14/199/14] Funding Source: researchfish; The Dunhill Medical
   Trust [DMT/RCS605] Funding Source: researchfish
FX This project was funded by the UK National Institute for Health Research
   Health Technology Assessment (HTA) Programme (project number 14/199/14)
   and was supported by the National Institute for Health Research (NIHR)
   Oxford Biomedical Research Centre.
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NR 28
TC 9
Z9 9
U1 0
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2018
VL 8
IS 6
AR e022115
DI 10.1136/bmjopen-2018-022115
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GJ7LG
UT WOS:000435567900103
PM 29880575
OA Green Submitted, Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Mariani, AW
   Lisboa, JBRM
   Rodrigues, GD
   Avila, EM
   Terra, RM
   Pêgo-Fernandes, PM
AF Mariani, Alessandro Wasum
   Ribeiro Machado Lisboa, Joao Bruno
   Rodrigues, Guilherme de Abreu
   Avila, Ester Moraes
   Terra, Ricardo Mingarini
   Pego-Fernandes, Paulo Manuel
TI Mini-thoracostomy with vacuum-assisted closure: a minimally invasive
   alternative to open-window thoracostomy
SO JORNAL BRASILEIRO DE PNEUMOLOGIA
LA English
DT Article
DE Infection; Empyema; pleural; Negative-pressure wound therapy;
   Thoracostomy
ID PLEURAL EMPYEMA; THERAPY; MANAGEMENT; MEDIASTINITIS; INSTILLATION;
   STATEMENT; SURGERY; DEVICE
AB Thoracostomy is a common treatment option for patients with stage III pleural empyema who do not tolerate pulmonary decortication. However, thoracostomy is considered mutilating because it involves a thoracic stoma, the closure of which can take years or require further surgery. A new, minimally invasive technique that uses the vacuum-assisted closure has been proposed as an alternative to thoracostomy. This study aims to analyze the safety and effectiveness of mini-thoracostomy with vacuum-assisted closure in an initial sample of patients.
C1 [Mariani, Alessandro Wasum; Ribeiro Machado Lisboa, Joao Bruno; Rodrigues, Guilherme de Abreu; Terra, Ricardo Mingarini; Pego-Fernandes, Paulo Manuel] Univ Sao Paulo, Fac Med, Disciplina Cirurgia Torac, Sao Paulo, SP, Brazil.
   [Avila, Ester Moraes] Univ Sao Paulo, Fac Med, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Mariani, AW (通讯作者)，HC FMUSP, Inst Coracao, Ave Dr Eneas Carvalho Aguiar,33 Bloco 2 Sala 9, BR-05403000 Sao Paulo, SP, Brazil.
EM awmariani@gmail.com
RI ; Mariani, Alessano/F-8015-2014; Pêgo Fernandes, Paulo
   Manuel/AAC-8319-2020
OI Avila, Ester/0000-0001-5939-8998; Terra, Ricardo
   Mingarini/0000-0001-8577-8708; Mariani, Alessano/0000-0002-3004-1351;
   Pêgo Fernandes, Paulo Manuel/0000-0001-7243-5343
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo
   Research Foundation) [15/133611-7]
FX This study received financial support from the Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo Research Foundation;
   Grant no. 15/133611-7).
CR ANDREWS NC, 1962, AM REV RESPIR DIS, V85, P935
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NR 17
TC 1
Z9 2
U1 0
U2 0
PU SOC BRASILEIRA PNEUMOLOGIA TISIOLOGIA
PI BRASILIA DF
PA SEPS 714-719, BLOCO E ASA SUL, SALAS 220-223, BRASILIA DF, CEP70390-145,
   BRAZIL
SN 1806-3713
EI 1806-3756
J9 J BRAS PNEUMOL
JI J. Bras. Pneumol.
PD MAY-JUN
PY 2018
VL 44
IS 3
BP 227
EP 230
DI 10.1590/S1806-37562017000000167
PG 4
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA GJ7QC
UT WOS:000435582000015
PM 29947716
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tewarie, L
   Chernigov, N
   Goetzenich, A
   Moza, A
   Autschbach, R
   Zayat, R
AF Tewarie, Lachmandath
   Chernigov, Nikolay
   Goetzenich, Andreas
   Moza, Ajay
   Autschbach, Ruediger
   Zayat, Rashad
TI The Effect of Ultrasound-Assisted Debridement Combined with Vacuum Pump
   Therapy in Deep Sternal Wound Infections
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE cardiac surgery; postoperative complications; sternal wound infection;
   ultrasonic-assisted wound debridement; vacuum-assisted wound closure
ID LOW-FREQUENCY ULTRASOUND; VENOUS LEG ULCERS; BIOFILMS; EXPERIENCE;
   BACTERIAL; CLOSURE
AB Purpose: To assess whether a combined treatment of low-frequency (25 kHz) ultrasonic-debridement systems followed by vacuum-assisted wound closure (VAC) produces a better outcome in deep sternal wound infections (SWIs) compared to that of VAC alone.
   Methods: We evaluated 45 consecutive patients (25 males) between January 2013 and December 2016, in whom deep SWI was treated with a combination of low-frequency ultrasonic debridement system followed by vacuum-assisted closure (group A, n = 23) or with only vacuum-assisted closure therapy (group B, n = 22). Our final step in both groups was a secondary wound closure with a musculocutaneous flap.
   Results: In both groups, a similar variety of bacteria were isolated. The time between eradication and secondary wound closure was significantly shorter in group A (7.3 +/- 4.8 vs. 19.9 +/- 17.2 days, p = 0.001). After a third debridement session, 95.7% of microbiological cultures were negative in group A versus 54.5% in B (p = 0.001). Duration of antibiotic treatment (p = 0.003) and hospitalization time (p = 0.0001) were significantly shorter in group A.
   Conclusion: The use of low-frequency ultrasonic debridement system is an effective, less invasive technique to combat wound infection. In combination with vacuum-assisted closure therapy, we documented good mid-term results in our patients.
C1 [Tewarie, Lachmandath; Chernigov, Nikolay; Goetzenich, Andreas; Moza, Ajay; Autschbach, Ruediger; Zayat, Rashad] RWTH Univ Hosp, Dept Thorac & Cardiovasc Surg, Pauwelsstr 30, D-52074 Aachen, Germany.
C3 RWTH Aachen University; RWTH Aachen University Hospital
RP Zayat, R (通讯作者)，RWTH Univ Hosp, Dept Thorac & Cardiovasc Surg, Pauwelsstr 30, D-52074 Aachen, Germany.
EM rzayat@ukaachen.de
RI Goetzenich, Andreas/ISB-7317-2023; Zayat, Rashad/K-1543-2019; Moza,
   Ajay/KFR-7226-2024
OI Goetzenich, Andreas/0000-0002-3652-7766; Zayat,
   Rashad/0000-0003-2243-8743; 
FU Soring, Quickborn, Germany
FX This study was supported by a research grant from Soring, Quickborn,
   Germany. LT received the grant. The sponsor was not involved in any
   phase of the study preparation, data collection, data analysis, or
   manuscript preparation.
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NR 19
TC 9
Z9 14
U1 0
U2 3
PU MEDICAL TRIBUNE INC
PI TOKYO
PA ED COMM ANNALS THORACIC CARDIOVASCULAR SURG, 2-1-30 KUDAN MINAMI,
   CHIYODA-KU, TOKYO, 102-0074, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2018
VL 24
IS 3
BP 139
EP 146
DI 10.5761/atcs.oa.17-00244
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA GJ7RK
UT WOS:000435586500004
PM 29563372
OA gold
DA 2026-07-24
ER
PT J
AU Bazalinski, D
   Wiech, P
   Baranska, B
   Binkowska-Bury, M
AF Bazalinski, Dariusz
   Wiech, Pawel
   Baranska, Beata
   Binkowska-Bury, Monika
TI Use of negative pressure wound therapy in a chronic leg wound with
   coexisting rheumatoid arthritis: a case study
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Negative pressure wound therapy; chronic leg wound; rheumatoid
   arthritis; bacterial count; infection; steroid
ID VACUUM-ASSISTED CLOSURE; DISEASE; ULCERS; CARE
AB We present a case of a 69-year-old woman with rheumatoid arthritis. The patient's condition was managed with steroid therapy for more than 12 years. She had a coexisting infected chronic ulceration in the left leg, which was treated with negative pressure wound therapy for 52 days. Use of this therapy within the wound reduced exudate and the bacterial count, which dramatically accelerated the process of wound healing.
C1 [Bazalinski, Dariusz; Wiech, Pawel; Binkowska-Bury, Monika] Univ Rzeszow, Inst Nursing & Hlth Sci, Fac Med, Rzeszow, Poland.
   [Bazalinski, Dariusz; Baranska, Beata] Specialist Hosp, Podkarpackie Oncol Ctr Brzozow, Rzeszow, Poland.
C3 University of Rzeszow
RP Wiech, P (通讯作者)，Inst Nursing & Hlth Sci, Al Kopisto 2a, PL-35310 Rzeszow, Poland.
EM p.k.wiech@gmail.com
RI ; bazaliński, dariusz/AFN-7652-2022
OI Binkowska-Bury, Monika/0000-0002-1182-6727; Więch,
   Paweł/0000-0002-0101-1030; bazaliński, dariusz/0000-0003-1717-1319
CR Apelqvist J, 2017, J WOUND CARE, V26, P1
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NR 14
TC 2
Z9 3
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD JUN
PY 2018
VL 46
IS 6
BP 2495
EP 2499
DI 10.1177/0300060518771826
PG 5
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GK3KZ
UT WOS:000436045200043
PM 29756537
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pierson, RC
   Scott, NP
   Briscoe, KE
   Haas, DM
AF Pierson, Rebecca C.
   Scott, Nicole P.
   Briscoe, Kristin E.
   Haas, David M.
TI A review of post-caesarean infectious morbidity: how to prevent and
   treat
SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Review
DE Caesarean section; wound infection; surgical site infection
ID SURGICAL SITE INFECTION; PRESSURE WOUND THERAPY;
   MATERNAL-FETAL-MEDICINE; CESAREAN DELIVERY; RISK-FACTORS; OBESE WOMEN;
   GLYCEMIC CONTROL; SKIN CLOSURE; COMPLICATIONS; MANAGEMENT
AB Post-caesarean infectious complications result in significant maternal morbidity and mortality as well as increased readmissions and increased health care cost worldwide. This review provides a discussion of several risk factors that have been identified which predispose women to post-surgical infection. We also provide an overview of strategies for infection prevention including antibiotics, surgical techniques and negative pressure wound therapy. Criteria for diagnosis of wound infection are provided, as well as appropriate treatment regimens. Given the impact of maternal post caesarean infection, it is important for women's health care providers to understand how to prevent these infections, as well as recognise and treat them.
C1 [Pierson, Rebecca C.] Univ Louisville, Dept Obstet Gynecol & Womens Hlth, Ambulatory Care Bldg,2nd Floor Bridge, Louisville, KY 40202 USA.
   [Scott, Nicole P.; Haas, David M.] Indiana Univ, Dept Obstet & Gynecol, Indianapolis, IN 46204 USA.
   [Briscoe, Kristin E.] Univ Florida, Dept Obstet & Gynecol, Gainesville, FL 32611 USA.
C3 University of Louisville; Indiana University System; Indiana University
   Indianapolis; State University System of Florida; University of Florida
RP Pierson, RC (通讯作者)，Univ Louisville, Dept Obstet Gynecol & Womens Hlth, Ambulatory Care Bldg,2nd Floor Bridge, Louisville, KY 40202 USA.
EM rebecca.pierson@louisville.edu
OI Pierson, Rebecca C/0000-0002-6688-8829; Haas, David/0000-0002-8379-0743
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NR 67
TC 15
Z9 19
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0144-3615
EI 1364-6893
J9 J OBSTET GYNAECOL
JI J. Obstet. Gynaecol.
PY 2018
VL 38
IS 5
BP 591
EP 597
DI 10.1080/01443615.2017.1394281
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA GK8BQ
UT WOS:000436441700001
PM 29433350
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Tutton, E
   Achten, J
   Lamb, SE
   Willett, K
   Costa, ML
AF Tutton, Elizabeth
   Achten, Juul
   Lamb, Sarah E.
   Willett, Keith
   Costa, Matthew L.
CA UK WOLLF Res Collaborators
TI Participation in a trial in the emergency situation: a qualitative study
   of patient experience in the UK WOLLF trial
SO TRIALS
LA English
DT Article
DE Qualitative; Interviews; Experience; Consent; Emergency; Trial
ID OPEN FRACTURE; LOWER-LIMB; MANAGEMENT; CONSENT
AB Background: Patients can struggle to make sense of trials in emergency situations. This study examines patient experience of participating in the United Kingdom, Wound management of Open Lower Limb Fractures (UK WOLLF) study, a trial of standard wound management versus Negative Pressure Wound Therapy (NPWT).
   Methods: The aim of the study was to understand the patient's lived experience of taking part in a trial of wound dressings. Interviews drawing on Phenomenology were undertaken with a purposive sample of 20 patients, on average 12 days into their hospital stay from July 2012-July 2013.
   Results: The participants were vulnerable due to the emotional and physical impact of injury. They expressed their trial experience through the theme of being compromised identified in categories of being dependent being trusting, being grateful and being without experience. Participants felt dependent on and trusted the team to make the right decisions for them and not cause them harm. Their hopes for future recovery were also invested within the expertise of the team. Despite often not being well enough to consent to the study prior to surgery, they wished to be involved as much as possible. In agreeing to take part they expressed gratitude for their care, wanted to be helpful to others and considered the trial interventions to be a small component in relation to the enormity of their injury and broader treatment In making sense of the trial they felt they could not understand the interventions without experience of them but if they received NPWT they developed a strong technological preference for this intervention.
   Conclusions: Patients prefer to be involved in studies within the limits of their capacity, despite not being able to provide informed consent A variety of sources of knowledge may enable participants to feel that they have a better understanding of the interventions. Professional staff need to be aware of the situated nature of decision making where participants invest their hopes for recovery in the team.
C1 [Tutton, Elizabeth] Univ Warwick, Warwick Med Sch, Warwick Res Nursing, Gibbet Hill Campus, Coventry CV4 7AL, W Midlands, England.
   [Tutton, Elizabeth; Willett, Keith] Oxford Univ Hosp NHS Fdn Trust, John Radcliffe Hosp, Kadoorie Ctr, Oxford OX3 9DU, England.
   [Achten, Juul; Lamb, Sarah E.; Costa, Matthew L.] Univ Warwick, Warwick Med Sch, Clin Trials Unit, Gibbet Hill Campus, Coventry CV4 7AL, W Midlands, England.
   [Achten, Juul; Lamb, Sarah E.; Willett, Keith; Costa, Matthew L.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford OX3 9DU, England.
   [Costa, Matthew L.] Univ Hosp Coventry, Clifford Bridge Rd, Coventry CV2 2DX, W Midlands, England.
   [Costa, Matthew L.] Warwickshire NHS Trust, Clifford Bridge Rd, Coventry CV2 2DX, W Midlands, England.
C3 University of Warwick; Oxford University Hospitals NHS Foundation Trust;
   University of Oxford; University of Warwick; University of Oxford;
   University of Warwick
RP Tutton, E (通讯作者)，Univ Warwick, Warwick Med Sch, Warwick Res Nursing, Gibbet Hill Campus, Coventry CV4 7AL, W Midlands, England.; Tutton, E (通讯作者)，Oxford Univ Hosp NHS Fdn Trust, John Radcliffe Hosp, Kadoorie Ctr, Oxford OX3 9DU, England.
EM liz.tutton@warwick.ac.uk
RI Achten, Juul/KUD-8515-2024
OI Achten, Juul/0000-0002-8857-5743; Costa, Matthew/0000-0003-3644-1388;
   Lamb, Sarah/0000-0003-4349-7195; Tutton, Elizabeth/0000-0003-3973-360X
FU NIHR Health Technology Assessment programme, NIHR HTA [10/57/20];
   Economic and Social Research Council [1499410] Funding Source:
   researchfish; Medical Research Council [G0700452, G0501681] Funding
   Source: researchfish; National Institute for Health Research
   [NF-SI-0616-10103, 14/199/14, 10/57/20] Funding Source: researchfish;
   MRC [G0700452, G0501681] Funding Source: UKRI
FX This study was funded by the NIHR Health Technology Assessment
   programme, NIHR HTA (10/57/20). The views expressed are those of the
   authors and not necessarily those of the NHS, the NIHR or the Department
   of Health.
CR Canvin K, 2006, TRIALS, V7, DOI 10.1186/1745-6215-7-32
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NR 25
TC 12
Z9 15
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUN 25
PY 2018
VL 19
AR 328
DI 10.1186/s13063-018-2722-4
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA GL0XY
UT WOS:000436818800001
PM 29941030
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Karam, RA
   Rezk, NA
   Rahman, TMA
   Al Saeed, M
AF Karam, Rehab A.
   Rezk, Noha A.
   Rahman, Tamer M. Abdel
   Al Saeed, Mohamed
TI Effect of negative pressure wound therapy on molecular markers in
   diabetic foot ulcers
SO GENE
LA English
DT Article
DE Diabetic foot ulcers: NPWT; Growth factors; Metalloproteinase
ID VACUUM-ASSISTED CLOSURE; MATRIX METALLOPROTEINASES; EXPRESSION; REPAIR;
   KERATINOCYTES; MECHANISMS; TRIAL; MMP-9; VEGF
AB Diabetic foot ulcers are one of the most common complications of diabetes with high morbidity and mortality. Negative pressure wound therapy (NPWT) is one of the treatment modalities that facilitates the wound healing process; however, its molecular mechanism remains unclear. The aim of this study was to investigate the mechanism of action of NPWT in the treatment of diabetic foot ulcers via measuring the tissue expression of genes related to the wound healing process. The study included 40 patients with diabetic foot ulceration, 20 of them received NPWT and the other 20 were a control group treated with advanced moist therapy. Granulation tissue biopsies were obtained before and 10 days after treatment in both groups and subjected to real-time polymerase chain reaction to measure the mRNA expression of TGF-beta 1, VEGF, TNF-alpha, IL-1 beta, MMP-1, MMP-9 and TIMP-1 which are involved in the wound healing pathway. After 10 days of treatment with NPWT, the mRNA levels of IL -1 beta, TNF-alpha, MMP-1, and MMP-9 were significantly downregulated, while the levels of VEGF, TGF-beta 1 and TIMP-1 were significantly increased. Our study demonstrated that NPWT promotes wound healing in diabetic foot ulcers possibly by affecting growth factors, inflammatory cytokines, and matrix metalloproteinases.
C1 [Karam, Rehab A.; Rezk, Noha A.] Zagazig Univ, Fac Med, Med Biochem Dept, Zagazig 44512, Egypt.
   [Karam, Rehab A.] Taif Univ, Biochem Dept, Fac Med, Al Taif, Saudi Arabia.
   [Rahman, Tamer M. Abdel] Gen Org Teaching Hosp & Inst, Cairo, Egypt.
   [Rahman, Tamer M. Abdel; Al Saeed, Mohamed] Taif Univ, Surg Dept, Coll Med, Al Taif, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Taif University;
   Egyptian Knowledge Bank (EKB); General Organization of Teaching
   Hospitals & Institutes (GOTHI); Taif University
RP Rezk, NA (通讯作者)，Zagazig Univ, Fac Med, Med Biochem Dept, Zagazig 44512, Egypt.
EM Narizk@zu.edu.eg
RI ; Ahmed Karam, Rehab/T-3604-2019
OI rezk, noha/0000-0002-5199-0134; Ahmed Karam, Rehab/0000-0001-9750-3218
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NR 44
TC 30
Z9 37
U1 1
U2 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD AUG 15
PY 2018
VL 667
BP 56
EP 61
DI 10.1016/j.gene.2018.05.032
PG 6
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA GL1RK
UT WOS:000436884000007
PM 29758297
DA 2026-07-24
ER
PT J
AU Colak, B
   Kirazli, H
   Ece, I
   Yormaz, S
   Sahin, M
AF Colak, Bayram
   Kirazli, Halil
   Ece, Ilhan
   Yormaz, Serdar
   Sahin, Mustafa
TI COMPARISION OF VACUUM-ASISTED CLOSURE AND INTRALESIONAL EPIDERMAL GROWTH
   FACTOR IN THE TREATMENT OF DIABETIC FOOT WOUNDS PATIENTS
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Growth factor; diabetic foot; negative pressure; wound
ID LOWER-EXTREMITY ULCERS; ASSISTED CLOSURE; THERAPY; PRESSURE; TRIAL
AB Introduction: Diabetes mellitus (DM) is a common public health problem all over the world with serious complications. The mortality rate is 40% within 5 years in patients with major amputation due to diabetic foot wounds (DFW). Therefore, a nonsurgical but effective treatment method is needed for the treatment of DFW. In this study, we aimed to compare the results of intralesional epidermal growth factor (EGF) injection and negative pressure wound therapy (NPWT) for the treatment of DFW.
   Materials and methods: The medical records of patients who were treated for DFW with EGF or NPWT between February 2017 and December 2017 were retrospectively reviewed. Patients demographics, wound characteristics, allergic reactions and treatment responses were evaluated.
   Results: Amongst 42 patients, 20 patients were treated with the injection of EGF and 22 patients treated with NPWT. The duration of diabetes was higher in EGF group when compared to the NPWT group without a statistically significance (EGF: 20,7 years, NPWT: 16,9 years). According to the Wagner-Meggitt classification, the grade of the wounds was comparable in both groups. A complete response were obtained in 17 (85%) patients and 50% wound closure was achieved in the other patients in EGF group. In the NPWT group complete response rate was 45.4%. No major amputation was performed in any patient. In NPWT group, 13 (59%) of wouds were closed with split-thickness skin graft, only 3 patients (15%) of the EGF group were required a skin graft. The main advers affect of the EGF injection was an elevated fasting blood glucose level. In both groups, A decreased HbA1c levels were found after the wound treatment.
   Conclusion: Both administration of intralesional EGF and NPWT are safe, effective and non-surgical methods for the treatment of DFW. NPWT is seems to be a more effective treatment modality for infected wounds.
C1 [Colak, Bayram; Kirazli, Halil; Ece, Ilhan; Yormaz, Serdar; Sahin, Mustafa] Selcuk Univ, Fac Med, Dept Gen Surg, Konya, Turkey.
C3 Selcuk University
RP Colak, B (通讯作者)，Selcuk Univ, Fac Med, Dept Gen Surg, Konya, Turkey.
EM bayro.99@gmail.com
RI Ece, ilhan/AAR-9923-2020; çolak, bayram/ABQ-2400-2022; sahin,
   mustafa/AAH-3394-2019
OI çolak, bayram/0000-0003-1403-6963; sahin, mustafa/0000-0002-4718-0083
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NR 47
TC 1
Z9 1
U1 0
U2 7
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2018
VL 34
IS 5
BP 1245
EP 1252
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GL3JV
UT WOS:000437030700013
DA 2026-07-24
ER
PT J
AU Mikami, T
   Kaida, E
   Yabuki, Y
   Kitamura, S
   Kokubo, K
   Maegawa, J
AF Mikami, Taro
   Kaida, Eriko
   Yabuki, Yuichiro
   Kitamura, Sho
   Kokubo, Ken'ichi
   Maegawa, Jiro
TI Negative PressureWound Therapy Followed by Basic Fibroblast Growth
   Factor Spray as a Recovery Technique in Partial Necrosis of Distally
   Based Sural Flap for Calcaneal Osteomyelitis: A Case Report
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE calcaneal osteomyelitis; diabetic foot; flap necrosis
ID WOUND THERAPY; DIABETIC FOOT; QUALITY; CLOSURE; HEEL; RECONSTRUCTION;
   ULCERATIONS; AMPUTATION; FRACTURES; SALVAGE
AB The distally based sural flap is regarded as the first choice for reconstruction in the distal part of the lower leg because the flap is easy to raise, reliable in its blood supply, and prone to only a few complications. Limited data have investigated the details of treatment in cases of failure of distally based sural flaps. We report a case of calcaneal osteomyelitis in which a successful outcome was finally obtained with a partially necrosed, distally based sural flap using negative pressure wound therapy with basic fibroblast growth factor spray. The 2-year follow-up examination was uneventful. Moreover, the patient was able to walk freely with an ankle-foot orthosis in her house. This technique can be considered as a useful and effective option to recover unfavorable results of distally based sural flaps. (c) 2017 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Mikami, Taro; Kaida, Eriko; Kitamura, Sho; Kokubo, Ken'ichi] Fujisawa Shounandi Hosp, Dept Plast & Reconstruct Surg, Fujisawa, Kanagawa, Japan.
   [Mikami, Taro; Yabuki, Yuichiro; Maegawa, Jiro] Yokohama City Univ Med, Dept Plast & Reconstruct Surg, Yokohama, Kanagawa, Japan.
C3 Yokohama City University
RP Mikami, T (通讯作者)，Yokohama City Univ Med, Dept Plast & Reconstruct Surg, Kanazawa Ku, 236-004 Fukuura 3-9, Yokohama, Kanagawa, Japan.
EM zeong3@mac.com
OI Mikami, Taro/0000-0002-1381-2070
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NR 25
TC 8
Z9 9
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JUL-AUG
PY 2018
VL 57
IS 4
BP 816
EP 820
DI 10.1053/j.jfas.2017.11.011
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA GL3KJ
UT WOS:000437032500035
PM 29605553
DA 2026-07-24
ER
PT J
AU Bi, HD
   Li, JH
   Xue, CY
   Marks, M
AF Bi, Hongda
   Li, Junhui
   Xue, Chunyu
   Marks, Malcolm
TI Early Closure of Infected Laparotomy Wound with Negative-Pressure Wound
   Therapy: Safety and Efficacy in 42 Consecutive Cases
SO AMERICAN SURGEON
LA English
DT Article
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; FISTULA
   FORMATION; HIGH-RISK; PREVENTION; GUIDELINE; NPWT; MANAGEMENT; SURGERY
AB Postoperative surgical site infections (SSIs) are one of the most common complications. SSIs after laparotomy have a high incidence and are complicated and expensive to heal. The aim of this study was to evaluate the safety and efficacy of a novel therapy of early closure of open abdominal SSIs wound combining wound irrigation with negative pressure wound therapy (NPWT). Open abdominal SSIs wounds were closed with sutures in 42 consecutive patients. Topical NPWT was applied over a closed wound with a deep drain to allow dynamic drainage and wound irrigation. CT scan with contrast medium injected through the deep drain was performed in patients with suspicious tracts detected during debridement surgery three days after surgery to identify a potential fistula. Wound healing and safety of the therapy was evaluated during an average six months follow-up. Closed wounds healed successfully in all the patients without recurrence of wound infection. Fistulas were easily diagnosed in all four fistula patients by using CT scan with contrast medium injection through the wound. Fistula was confirmed in these four patients at reexploration. All the drain tube wounds healed spontaneously after drain removal. No severe adverse event occurred during therapy in any patients. With the aid of topical NPWT and deep drainage and irrigation, early closure of open SSIs wound can be done safely. We were also able to diagnose gastrointestinal fistulas at an early stage with the use of CT scan imaging after contrast injection into the wound.
C1 [Bi, Hongda; Li, Junhui; Xue, Chunyu] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai, Peoples R China.
   [Marks, Malcolm] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27103 USA.
C3 Naval Medical University; Wake Forest University; Wake Forest Baptist
   Medical Center
RP Marks, M (通讯作者)，Wake Forest Baptist Med Ctr, Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM mmarks@wakehealth.edu
CR Barker DE, 2007, J AM COLL SURG
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NR 35
TC 2
Z9 2
U1 0
U2 5
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JUN
PY 2018
VL 84
IS 6
BP 938
EP 946
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GM4JF
UT WOS:000438084600045
PM 29981628
DA 2026-07-24
ER
PT J
AU Kiliçoglu, ÖI
   Demirel, M
   Aktas, S
AF Kilicoglu, Onder I.
   Demirel, Mehmet
   Aktas, Samil
TI New trends in the orthopaedic management of diabetic foot
SO EFORT OPEN REVIEWS
LA English
DT Article
DE diabetic foot; Charcot foot
ID PRESSURE WOUND THERAPY; METATARSAL HEAD RESECTION; HYPERBARIC-OXYGEN
   THERAPY; TIBIOTALOCALCANEAL ARTHRODESIS; CHARCOT NEUROARTHROPATHY;
   SURGICAL-MANAGEMENT; JOINT ARTHROPLASTY; PLANTAR PRESSURE; ULCER
   PREVENTION; GROWTH-FACTOR
AB Although there are various types of therapeutic footwear currently used to treat diabetic foot ulcers (DFUs), recent literature has enforced the concept that total-contact casts are the benchmark.
   Besides conventional clinical tests and imaging modalities, advanced MRI techniques and high-sensitivity nuclear medicine modalities present several advantages for the investigation of diabetic foot problems.
   The currently accepted principles of DFU care are rigorous debridement followed by modern wound dressings to provide a moist wound environment. Recently, hyperbaric oxygen and negative pressure wound therapy have aroused increasing attention as an adjunctive treatment for patients with DFUs.
   For DFU, various surgical treatments are currently available, including resection arthroplasty, metatarsal osteotomies and metatarsal head resections.
   In the modern management of the Charcot foot, surgery in the acute phase remains controversial and under investigation. While conventional fixation techniques are frequently insufficient to keep alignment postoperatively, superconstruct techniques could provide a successful fixation.
   Retrograde intramedullary nailing has been a generally accepted method of achieving stability. The midfoot fusion bolt is a current treatment device that maintains the longitudinal columns of the foot. Also, Achilles tendon lengthening remains a popular method in the management of Charcot foot.
C1 [Kilicoglu, Onder I.; Demirel, Mehmet] Istanbul Univ, Istanbul Fac Med, Dept Orthopaed & Traumatol, Istanbul, Turkey.
   [Aktas, Samil] Istanbul Univ, Istanbul Fac Med, Dept Underwater & Hyperbar Med, Istanbul, Turkey.
C3 Istanbul University; Istanbul University
RP Kiliçoglu, ÖI (通讯作者)，Istanbul Univ, Istanbul Fac Med, Millet Cad 118, TR-34093 Istanbul, Turkey.
EM onder.kilicoglu@gmail.com
RI Kılıçoğlu, Önder İsmet/B-2810-2011; /AAD-6656-2020; demirel,
   mehmet/AAN-7795-2020
OI Kılıçoğlu, Önder İsmet/0000-0003-0023-7094; demirel,
   mehmet/0000-0003-1131-7719
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NR 100
TC 8
Z9 13
U1 1
U2 23
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 2396-7544
EI 2058-5241
J9 EFORT OPEN REV
JI EFORT Open Rev.
PD MAY
PY 2018
VL 3
IS 5
BP 269
EP 277
DI 10.1302/2058-5241.3.170073
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA GN3YR
UT WOS:000438949600016
PM 29951266
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mercut, R
   Sinna, R
   Vaucher, R
   Giroux, PA
   Assaf, N
   Lari, A
   Dast, S
AF Mercut, R.
   Sinna, R.
   Vaucher, R.
   Giroux, P. A.
   Assaf, N.
   Lari, A.
   Dast, S.
TI Triple flap technique for vulvar reconstruction
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA English
DT Article
DE Vulvar cancer; Reconstruction; V-Y advancement flaps; Pudendal
   perforator
ID VACUUM-ASSISTED CLOSURE; V-Y FLAP; ABDOMINOPERINEAL RESECTION; PERINEAL
   RECONSTRUCTION; VAGINAL RECONSTRUCTION; CANCER; MANAGEMENT
AB Objective. - Perineal defects are encountered ever more frequently, in the treatment of vulvar cancers or abdominoperineal resection. The surgical treatment of vulvar cancer leads to significant skin defect. The aim of the reconstruction is not to provide volume but rather to resurface perineum. We propose a new solution to cover the extensive skin defect remaining after excision.
   Methods. - We report 3 patients who underwent large excision for vulvar cancer, with lymph node dissection. For reconstruction, we performed 3 advancement flaps. Two V-Y flaps cantered on the infra-gluteal folds and based on pudendal perforator arteries were used to cover the postero-lateral parts of the defect. The third advancement flap from the superior aspect of the defect was a Y-V Mons pubis flap.
   Results. - The defects were successfully covered by the 3 flap technique. The first patient suffered a non-union that slowly healed by secondary intention. For the other cases, we used the same technique, but applied negative pressure wound therapy on the sutures, with excellent results.
   Conclusion. - The 3 flap technique is a simple and reliable method and the donor site morbidity is minimal. It can be realised without changing the position of the patient after tumour excision, and does not require delicate perforator dissection. This surgical option can be easily applied, allowing better management of these cases. (C) 2018 Elsevier Masson SAS. All rights reserved.
C1 [Mercut, R.; Sinna, R.; Vaucher, R.; Giroux, P. A.; Assaf, N.; Dast, S.] Univ Hosp Picardie, Dept Plast Reconstruct & Aesthet Surg, F-80054 Picardie 1, France.
   [Lari, A.] CHU Lyon, Serv Chirurg Plast Reconstructrice & Esthet, Hop Croix Rousse, 103 Grande Rue Croix Rousse, Lyon, France.
C3 CHU Lyon
RP Dast, S (通讯作者)，Amiens Univ Hosp, Dept Plast Reconstruct & Aesthet Surg, F-80054 Amiens 01, France.
EM s.dast@hotmail.fr
RI /AAR-2977-2021
CR Artioukh DY, 2007, COLORECTAL DIS, V9, P362, DOI 10.1111/j.1463-1318.2006.01159.x
   Besset M, 2014, ANN CHIR PLAST ESTH, V59, P53, DOI 10.1016/j.anplas.2013.04.001
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NR 18
TC 5
Z9 5
U1 0
U2 2
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
EI 1768-319X
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD JUL
PY 2018
VL 63
IS 4
BP 343
EP 348
DI 10.1016/j.anplas.2018.03.007
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GN4VL
UT WOS:000439037400010
PM 29650262
DA 2026-07-24
ER
PT J
AU Dua, A
   Rothenberg, KA
   Lavingia, K
   Ho, VT
   Rao, C
   Desai, SS
AF Dua, Anahita
   Rothenberg, Kara A.
   Lavingia, Kedar
   Ho, Vy T.
   Rao, Christina
   Desai, Sapan S.
TI Outcomes of Gracilis Muscle Flaps in the Management of Groin
   Complications after Arterial Bypass with Prosthetic Graft
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 41st Annual Meeting of the Midwestern-Vascular-Surgical-Society
CY SEP 07-09, 2017
CL Chicago, IL
SP Midwestern Vasc Surg Soc
ID INFECTIONS; COVERAGE
AB Background: This study details 2-year outcomes of a modified gracilis muscle flap (GMF) technique in providing tissue coverage for groin complications after arterial bypass surgery with synthetic graft.
   Methods: All patients who developed groin infections after lower extremity arterial bypass with synthetic graft who underwent a GMF technique were included from June 2014 to March 2017 from a prospectively collected, purpose-built institutional database. Modifications to the standard technique included identification of the muscle using ultrasound to ensure precise skip incisions, preservation of the segmental blood supply, widening of the tunnel through which the muscle is retroflexed, placement of a wound vacuum-assisted closure for healing, and lifelong antibiotics. Demographics, laboratory values, bypass procedure, length of stay (LOS), disposition, and 1-, 3-, 6-, 12-, and 24-month follow-up data were collected. Analysis was performed via descriptive statistics.
   Results: Over the 3-year study period, 22 patients underwent GMF after complications resulted from arterial bypass surgery. Types of bypass included aortobifemoral (32%), axillobifemoral (14%), femoral-femoral (23%), femoral-popliteal or mixed distal (27%), and thigh graft for dialysis (4%). Forty-five percentage of patients presented with graft infection, 50% with wound dehiscence, and 5% with graft disruption and bleeding. Only 23% of patients were candidates for sartorius muscle flap at the time of their initial procedure. The average case length was 64 + 19 min. Sixty-four percentage of patients were discharged home with home health care and the remainder to a skilled nursing facility. The average LOS was 6.1 + 3.4 days. Fifty-four percentages of wounds were healed at 1 month and 100% at 3 months with adjunctive vacuum-assisted closure therapy and lifelong antibiotics. Sixty percentage of patients were still alive at 24 months, with 33% of grafts still patent at that time. Median survival was 18.1 months, and median graft patency was 17.9 months.
   Conclusions: GMF is a safe and effective treatment for groin complications after arterial bypass surgery with synthetic graft. Owing to its versatility, area of coverage, ease of use, and durability, it potentially should be considered as a primary form of muscle coverage for groin complications.
C1 [Dua, Anahita; Rothenberg, Kara A.; Lavingia, Kedar; Ho, Vy T.] Stanford Hlth Care, Dept Surg, Div Vasc Surg, Stanford, CA USA.
   [Rao, Christina; Desai, Sapan S.] Northwest Community Hosp, Dept Vasc Surg, Arlington Hts, IL 60005 USA.
C3 Stanford University; Stanford Medicine
RP Desai, SS (通讯作者)，Northwest Community Hosp, Dept Vasc Surg, Arlington Hts, IL 60005 USA.
EM sapan.desai@surgisphere.com
OI Rothenberg, Kara/0000-0002-5123-5876; Ho, Vy Thuy/0000-0002-5570-0536
CR Ali AT, 2016, J VASC SURG, V64, P452, DOI 10.1016/j.jvs.2016.03.010
   Calligaro K D, 1994, Ann Vasc Surg, V8, P31, DOI 10.1007/BF02133403
   CHANG N, 1982, PLAST RECONSTR SURG, V70, P1
   DEVIRGILIO C, 1995, ANN VASC SURG, V9, P459, DOI 10.1007/BF02143860
   Fischer J, 2002, J VASC SURG, V55, P1081
   Herrera FA, 2009, AM SURGEON, V75, P877
   KIKTA MJ, 1987, J VASC SURG, V5, P566, DOI 10.1067/mva.1987.avs0050566
   Kishk T., 2010, EGYPT J PLAST RECONS, V34, P153
   Ktenidis K, 2012, CURRENT MANAGEMENT V
   Morasch MD, 2004, J VASC SURG, V39, P1277, DOI 10.1016/j.jvs.2004.02.011
   Rossetto LA, 2010, EUR J PLAST SURG, V33, P203, DOI 10.1007/s00238-010-0418-4
   Siracuse JJ, 2013, J VASC SURG, V57, P700, DOI 10.1016/j.jvs.2012.09.049
   Walter WR, 2016, CIRCULATION, V134, P412
   Young MH, 2012, INFECT DIS CLIN N AM, V26, P41, DOI 10.1016/j.idc.2011.09.004
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NR 15
TC 15
Z9 15
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD AUG
PY 2018
VL 51
BP 113
EP 118
DI 10.1016/j.avsg.2018.02.009
PG 6
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA GN5UO
UT WOS:000439132600018
PM 29660388
DA 2026-07-24
ER
PT J
AU Kiliç, E
   Ugur, M
   Yetim, I
   Temiz, M
AF Kilic, Erol
   Ugur, Mustafa
   Yetim, Ibrahim
   Temiz, Muhyittin
TI Effects of temporary abdominal closure methods on mortality and
   morbidity in patients with open abdomen
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Baker method; Bogota bag; Non-vacuum assisted closure method (NVACM);
   open abdomen; temporary abdomen closure; acuum-Assisted Closure Method
   (VACM)
ID MEDIATED FASCIAL TRACTION; ASSISTED WOUND CLOSURE; COMPARTMENT SYNDROME;
   MANAGEMENT; SEPSIS; TRAUMA
AB BACKGROUND: Open abdomen (OA) in which the abdomen is closed with temporary abdominal closure methods is the most effective in patients who develop severe abdominal sepsis or abdominal compartment syndrome. Major techniques used are Vacuum-Assisted Closure Method (VACM) and non-vacuum assisted closure method (NVACM). In the present study, the effects of different abdominal closure methods on morbidity and mortality were evaluated.
   METHODS: In the study, the temporary abdominal closure methods of the patients with OA during 2013-2016 were studied retrospectively. OA etiopathologies, mortality prediction scores, final abdominal closure periods and methods, hospitalization periods, complications (enteroatmospheric fistula, mesh infection, and incisional hernia), and mortality rates of patients who underwent VACM and NVACM were determined and compared.
   RESULTS: The present study included 123 patients who underwent VACM (n=65) and NVACM (n=58). There was no difference between the groups in terms of age, gender, and etiopathogenesis (p>0.05). The mean APACHE 4 and Multiple Organ Dysfunction Score (MODS) scores in the VACM/NVACM groups in treatment period were 47/63 and 11/14, respectively (p<0.05). The mean intensive care and hospitalization periods in the VACM/NVACM groups were 11/16 (days) and 22/28 (days), respectively (p<0.05). The collection and abscess development rates in the VACM and NVACM groups were 46.2% and 77.6%, respectively (p<0.05). The rate of enteroatmospheric fistula (EAF) development in the VACM and NVACM groups were 15.4% and 56.9%, respectively (p<0.05). The mean abdominal closure times in the VACM and NVACM groups were 13 and 17 days, respectively (p<0.05). Mortality rate in the VACM and NVACM groups were 18% (n=18) and 55% (n=32), respectively (p<0.05).
   CONCLUSION: In patients with OA, the temporary abdominal closure technique VACM has lower complication and mortality rates and shorter hospitalization period than other methods. Therefore, it is an effective and safe method for the treatment of OA.
C1 [Kilic, Erol; Ugur, Mustafa; Yetim, Ibrahim; Temiz, Muhyittin] Mustafa Kemal Univ, Dept Gen Surg, Fac Med, Antakya, Turkey.
C3 Hatay Mustafa Kemal University
RP Kiliç, E (通讯作者)，Mustafa Kemal Univ, Dept Gen Surg, Fac Med, Antakya, Turkey.
EM ekkilic55@gmail.com
RI ; Ugur, Mustafa/JAO-0517-2023
OI Yetim, İbrahim/0009-0001-7683-1260; Ugur, Mustafa/0000-0002-5922-2367
CR [Anonymous], 2007, OPUS 12 SCI
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NR 18
TC 1
Z9 6
U1 0
U2 5
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD JUL
PY 2018
VL 24
IS 4
BP 321
EP 326
DI 10.5505/tjtes.2017.95038
PG 6
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA GN8MU
UT WOS:000439418700007
PM 30028489
OA Bronze
DA 2026-07-24
ER
PT J
AU Song, HP
   Gong, YL
   Yan, XC
   Zhang, JP
AF Song, Huapei
   Gong, Yali
   Yan, Xiaochu
   Zhang, Jiaping
TI A Rare Case of Cutaneous Diffuse Large B-cell Lymphoma Presenting as a
   Chronic "Infectious" Skin Ulcer
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case report; wound; infection; cutaneous; lymphoma
AB Cutaneous diffuse large B-cell lymphoma (DLBCL) usually manifests as papules, nodules, or plaques. A rare case of a patient with a chronic skin ulcer and signs and symptoms of infection, including fever and large amounts of yellow wound exudate, is presented. Fifteen (15) months before diagnosis, a 43-year-old otherwise healthy man noted soreness without apparent cause in his upper chest and a palpable 2 cm x 2 cm focal lump. The patient developed frequent fevers, and the lump enlarged over time, producing purulent exudate. For 14 months, the patient was examined and treated at 5 hospitals, but biopsies, smears, cultures, and various types of nucleic acid testing were negative. Antibiotics to treat the suspected but nonclassified infection were ineffective. Ultimately, debridement and pathological examination of necrotic tissue from the deep sinus revealed DLBCL. The patient was provided chemotherapy, surgical debridement, and negative pressure wound therapy. Wounds started to reduce in size once chemotherapy was initiated. The wound was surgically closed with a split-skin graft, and the patient was discharged 93 days following admission to the authors' facility. This case illustrates the possibility of cutaneous DLBCL in patients with chronic skin ulcers and infectious manifestation that do not respond to antibiotic therapy. Prompt deep tissue debridement and pathological examination of deep tissue will help confirm the presence of cutaneous DLBCL and guide required chemotherapy.
C1 [Song, Huapei; Gong, Yali; Yan, Xiaochu; Zhang, Jiaping] Third Mil Med Univ, Southwest Hosp, State Key Lab Trauma Burns & Combined Injury, Inst Burn Res, Chongqing, Peoples R China.
C3 Army Medical University
RP Zhang, JP (通讯作者)，Third Mil Med Univ, Southwest Hosp, Inst Burn Res, Chongqing, Peoples R China.
EM 1980475546@qq.com
FU National Natural Science Foundation of China [81571900]
FX This project was supported by National Natural Science Foundation of
   China (81571900).
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NR 8
TC 1
Z9 2
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD APR
PY 2018
VL 64
IS 4
BP 44
EP 47
DI 10.25270/owm.2018.4.4447
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GN8QE
UT WOS:000439432200009
PM 29718817
DA 2026-07-24
ER
PT J
AU Chang, JW
   Heo, W
   Choi, MSS
   Lee, JH
AF Chang, Jung Woo
   Heo, Woong
   Choi, Matthew Seung Suk
   Lee, Jang Hyun
TI The appropriate management algorithm for diabetic foot A single-center
   retrospective study over 12 years
SO MEDICINE
LA English
DT Article
DE algorithm; diabetic foot; diabetic ulcer; management
ID PERIPHERAL ARTERIAL-DISEASE; ENDOVASCULAR TREATMENT; INFECTIONS; RISK;
   LIMB; SUPERMICROSURGERY; CLASSIFICATION; RECONSTRUCTION; OSTEOMYELITIS;
   REAMPUTATION
AB Background: Diabetic foot management is a challenge for reconstructive surgeons because it combines dramatically decreased circulation and chronic infection. The goal of managing this condition is to maximize viable tissue; however, unsatisfactory results, such as extremity amputation, are unavoidable in some cases. For appropriate management, thorough understanding of diabetic foot and the phased approach to its management is needed. The purpose of this study is to introduce an optimal algorithm for diabetic foot management by analyzing cases >12 years.
   Methods: A total of 274 patients with diabetic foot at Hanyang University Guri Hospital from 2005 to 2017 were reviewed. The management process was divided into 5 steps: patient evaluation, wound preparation, improving vascularity, surgery and dressing, and rehabilitation. Patient evaluation included a microbial culture, evaluation of vascularity, and an osteomyelitis assessment. During wound preparation, debridement and negative-pressure wound therapy were performed. Vascularity was improved by radiological intervention or surgical method. Surgery and dressing were performed depending on the indications. Rehabilitation was started after complete wound healing.
   Results: An infection was confirmed in 213 of 263 patients (81.0%). Of 74 cases in which a vascular study was performed, 83.8% showed arterial occlusion. When surgery was performed with complete eradication of the infection in 155 patients, the rate of revision surgery was 20.6%. The revision rate after surgery with a remnant infection of 66 patients was 40.9% (P=.0003). When surgery was performed after successful revascularization for improving blood flow of 47 patients, the rate of revision surgery was 21.3%. In contrast, the revision rate after surgery with unsuccessful or no revascularization of 174 patients was 28.2% (P=.359).
   Conclusion: Diabetic foot is a debilitating disease arising from multifactorial process. As its management is complex, a comprehensive but accessible treatment algorithm is needed for successful results. For this reason, the appropriate algorithm for diabetic foot management introduced in this study is significant.
C1 [Chang, Jung Woo; Heo, Woong; Choi, Matthew Seung Suk; Lee, Jang Hyun] Hanyang Univ, Coll Med, Guri Hosp, Dept Plast & Reconstruct Surg, 249-1 Gyomun Dong, Guri 471701, Gyeonggi Do, South Korea.
C3 Hanyang University
RP Lee, JH (通讯作者)，Hanyang Univ, Coll Med, Guri Hosp, Dept Plast & Reconstruct Surg, 249-1 Gyomun Dong, Guri 471701, Gyeonggi Do, South Korea.
EM pslee@hanyang.ac.kr
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NR 43
TC 7
Z9 9
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL
PY 2018
VL 97
IS 27
AR e11454
DI 10.1097/MD.0000000000011454
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GN9YH
UT WOS:000439569200075
PM 29979449
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Bazalinski, D
   Wiech, P
   Kaczmarska, D
   Salacinska, I
   Kózka, M
AF Bazalinski, Dariusz
   Wiech, Pawel
   Kaczmarska, Dorota
   Salacinska, Izabela
   Kozka, Maria
TI Use of controlled negative pressure in management of phlegmon caused by
   fulminant complication of pressure wound A case report
SO MEDICINE
LA English
DT Article
DE negative pressure wound therapy; phlegmon; pressure wound; tissue
   cleansing
ID THERAPY; ULCERS; CARE
AB Rationale: Effective wound healing depends on the adequate choice of the wound cleansing method, to enable rapid removal of necrotic tissue. Negative pressure wound therapy (NPWT) is an effective non-invasive technique for management of wounds of varied aetiology, including deep tissue injuries caused by pressure.
   Patient concerns: This article discusses a case of an 82-year-old female receiving hospice care at home owing to progressing untreated thoracic spinal stenosis, bedridden for 4 years, incapable of self-care.
   Diagnoses: Three fulminant pressure wounds, 50cm(2) each, with signs of undermining, Stage II/IV according to National Pressure Ulcer Advisory Panel, were identified in the area of the sacrum and the right and left trochanter. Despite measures used to prevent pressure sores, and nutritional supplementation, two months later a fourth pressure ulcer involving subcutaneous tissue was identified in the area of the right sciatic tuber, accompanied with signs of systemic inflammatory response, as well as massive phlegmon and lesion in the ischial bone.
   Interventions: As previously applied treatments (surgical necrectomy, biological therapy - Lucilia Sericata maggots, autolysis, pharmacological therapy) proved ineffective, NPWT was experimentally administered to evacuate exudate and to cleanse the wound.
   Outcomes: Application of negative pressure during a 42-day therapy allowed significantly faster cleansing of the wound. The pressure wounds was significantly reduced in size, and necrotic tissue was removed from the sciatic tuber, which ultimately was covered with granulation tissue.
   Lessons: Controlled negative pressure can successfully be used in the process of cleansing an infected pressure wound to safely remove exudate and to minimise local inflammation. Administration of controlled negative pressure is an effective and safe method in the process of cleansing an infected pressure wound.
C1 [Bazalinski, Dariusz; Wiech, Pawel; Salacinska, Izabela] Univ Rzeszow, Dept Med, Inst Nursing & Hlth Sci, Rzeszow, Poland.
   [Bazalinski, Dariusz; Kaczmarska, Dorota] Specialist Hosp Podkarpackie Oncol Ctr Brzozow, Brzozow, Poland.
   [Kozka, Maria] Jagiellonian Univ, Coll Med, Fac Hlth Sci, Dept Clin Nursing, Krakow, Poland.
C3 University of Rzeszow; Jagiellonian University; Collegium Medicum
   Jagiellonian University
RP Wiech, P (通讯作者)，Uniwers Rzeszow, Inst Nursin & Hlth Sci, Al Mjr W Kopisto 2 A, PL-35310 Rzeszow, Poland.
EM p.k.wiech@gmail.com
RI bazaliński, dariusz/AFN-7652-2022; Sałacińska, Izabela/V-8499-2019
OI bazaliński, dariusz/0000-0003-1717-1319; Więch,
   Paweł/0000-0002-0101-1030; Sałacińska, Izabela/0000-0003-1752-7610
FU Regional Operational Programme for the Podkarpackie Province
   [UDA-RPPK.01.03.00-18-004/12-00]
FX The study was performed as part of the project "Centre for Innovative
   Research in Medical and Natural Sciences" implemented by the University
   of Rzeszow, co-financed in the framework of 2007-2013 Regional
   Operational Programme for the Podkarpackie Province, contract number
   UDA-RPPK.01.03.00-18-004/12-00.
CR Apelqvist J, 2017, J WOUND CARE, V26, P1
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   Bazalinski D, 2017, LECZENIE RAN, V2, P1
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   Brown Gregory, 2003, Ostomy Wound Manage, V49, P42
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   Schiffman J, 2009, WORLD J SURG, V33, P1396, DOI 10.1007/s00268-009-0024-4
   Soares MO, 2013, MED DECIS MAKING, V33, P415, DOI 10.1177/0272989X12451058
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   White-Chu EF, 2011, CLIN GERIATR MED, V27, P241, DOI 10.1016/j.cger.2011.02.001
NR 20
TC 6
Z9 7
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL
PY 2018
VL 97
IS 28
AR e11319
DI 10.1097/MD.0000000000011319
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GO0AE
UT WOS:000439577500017
PM 29995766
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jimenez-Rodriguez, RM
   Araujo-Miguez, A
   Sobrino-Rodriguez, S
   Heller, F
   Díaz-Pavon, JM
   Bozada Garcia, JM
   De la Portilla, F
AF Maria Jimenez-Rodriguez, Rosa
   Araujo-Miguez, Angela
   Sobrino-Rodriguez, Salvador
   Heller, Frederick
   Diaz-Pavon, Jose M.
   Bozada Garcia, Juan M.
   De la Portilla, Fernando
TI A New Perspective on Vacuum-Assisted Closure for the Treatment of
   Anastomotic Leak Following Low Anterior Resection for Rectal Cancer, Is
   It Worthy?
SO SURGICAL INNOVATION
LA English
DT Article; Proceedings Paper
CT 16th Meeting of FAECP
CY MAY 14-16, 2014
CL SPAIN
SP FAECP
DE dehiscence; colorectal cancer; anterior resection; vacuum-assisted
   therapy
ID RISK-FACTORS; SURGERY; THERAPY; ETVARD
AB Background. Anastomotic dehiscence is a common complication of anterior resection. In this work, we evaluate the management of the pelvic cavity after low rectal resection using vacuum closure (VAC) with a gastroscope, and we establish factors that determine the success of closure and analyzed the rate of ileostomy closure after leakage was resolved. Patients and Methods. This is a descriptive case series analysis conducted at a tertiary hospital. Twenty-two patients with low colorectal anastomosis leakage or opening of the rectal stump after anterior resection for rectal cancer were included. They were treated with VAC therapy. Results. The total number of endoscopic sessions was 3.1 +/- 1.9 in the anterior resection with anastomosis group and 3.2 +/- 1.8 in the Hartmann group. In 11 patients the therapy was administered in an ambulatory setting. The mean time to healing was 22.3 +/- 14.7 days. Full resolution was achieved in 19 patients (followed-up 1 year). Ileostomy closure was carried out in 5 patients (38.46%) during follow-up. None of these patients showed leakage signs. Statistically significant differences were obtained depending on the onset of therapy, with better results in patients who underwent earlier vacuum-assisted therapy (before the sixth week after initial surgery), P = .041. Conclusions. VAC therapy is an alternative to surgery that can be safely administered in an ambulatory setting. Early administration in the 6 weeks following surgery is an independent predictive factor for successful closure; however, colonic transit was only recovered in a small percentage of patients.
C1 [Maria Jimenez-Rodriguez, Rosa; Araujo-Miguez, Angela; Sobrino-Rodriguez, Salvador; Diaz-Pavon, Jose M.; Bozada Garcia, Juan M.; De la Portilla, Fernando] Virgen del Rocio Univ Hosp, Seville, Spain.
   [Maria Jimenez-Rodriguez, Rosa; Diaz-Pavon, Jose M.; De la Portilla, Fernando] Univ Seville, CSIC, IBiS, Seville, Spain.
   [Heller, Frederick] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
   [De la Portilla, Fernando] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
C3 Virgen del Rocio University Hospital; Consejo Superior de
   Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE -
   Instituto de Biomedicina de Sevilla (IBIS); Memorial Sloan Kettering
   Cancer Center; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEREHD; Instituto de Salud Carlos III
RP Jimenez-Rodriguez, RM (通讯作者)，Hosp Univ Virgen del Rocio, Dept Cirugia Gen & Digest, Unidad Coloproctol, Avda Manuel Siurot S-N, Seville 41013, Spain.
EM ros_j_r@hotmail.com
RI de la Portilla, Fernando/ABD-5393-2020; /P-3148-2019
OI de la Portilla, Fernando/0000-0003-0603-2911; 
FU Instituto de Salud Carlos III, Madrid, Spain
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: CIBEREHD
   was funded by the Instituto de Salud Carlos III, Madrid, Spain.
CR Arezzo A, 2010, TECH COLOPROCTOL, V14, P279, DOI 10.1007/s10151-010-0569-0
   Bell SW, 2003, BRIT J SURG, V90, P1261, DOI 10.1002/bjs.4219
   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Eckmann C, 2004, INT J COLORECTAL DIS, V19, P128, DOI 10.1007/s00384-003-0498-8
   Glitsch A, 2008, ENDOSCOPY, V40, P192, DOI 10.1055/s-2007-995384
   Jestin P, 2008, COLORECTAL DIS, V10, P715, DOI 10.1111/j.1463-1318.2007.01466.x
   Keighley MRB, 1993, SURG ANUS RECTUM COL, P1024
   Kruschewski M, 2007, INT J COLORECTAL DIS, V22, P919, DOI 10.1007/s00384-006-0260-0
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   Matthiessen P, 2004, Colorectal Dis, V6, P462, DOI 10.1111/j.1463-1318.2004.00657.x
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   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
   Nagell CF, 2006, INT J COLORECTAL DIS, V21, P657, DOI 10.1007/s00384-005-0083-4
   Perathoner A, 2010, INT J COLORECTAL DIS, V25, P767, DOI 10.1007/s00384-010-0887-8
   Platell C, 2007, COLORECTAL DIS, V9, P71, DOI 10.1111/j.1463-1318.2006.01002.x
   Pliakos I, 2012, AM SURGEON, V78, P957
   Ptok H, 2007, BRIT J SURG, V94, P1548, DOI 10.1002/bjs.5707
   Rullier E, 1998, BRIT J SURG, V85, P355
   Srinivasamurthy D, 2013, TECH COLOPROCTOL, V17, P275, DOI 10.1007/s10151-012-0911-9
   von Bernstorff W, 2009, INT J COLORECTAL DIS, V24, P819, DOI 10.1007/s00384-009-0673-7
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 21
TC 17
Z9 22
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD AUG
PY 2018
VL 25
IS 4
BP 350
EP 356
DI 10.1177/1553350618771410
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA GO0KR
UT WOS:000439617900006
PM 29701133
DA 2026-07-24
ER
PT J
AU Delhougne, G
   Hogan, C
   Tarka, K
   Nair, S
AF Delhougne, Gary
   Hogan, Christopher
   Tarka, Kim
   Nair, Sunitha
TI A Retrospective, Cost-minimization Analysis of Disposable and
   Traditional Negative Pressure Wound Therapy Medicare Paid Claims
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE cost-minimization analysis; negative pressure wound therapy; durable
   medical equipment; disposable equipment
ID EVIDENCE-BASED RECOMMENDATIONS; DIABETIC FOOT ULCERS; INTERNATIONAL
   CONSENSUS; STEPS; CARE; BURDEN; HEALTH; TRIAL
AB Traditional negative pressure wound therapy (NPWT) systems are considered durable. The pump is designed for use by numerous patients over a period of several years. Recently developed smaller. disposable devices are designed for single-patient use. A retrospective analysis of 2012-2014 national Medicare claims data was used to examine payments associated with the use of traditional and disposable NPWT systems. Data extracted included NPWT episodes from the Limited Data Set Standard Analytic Files including the 5% sample for traditional NPWT and 100% sample for disposable NPWT. NPWT episodes were identified using claim service dates and billing codes. Mean costs per episode were compared and analyzed using chi-squared tests for comparisons between patients who received traditional and those who used disposable NPWT. For continuous variables, statistical significance was assessed using Mann-Whitney U tests. The data included traditional (n = 2938; mean age 66.6 years) and disposable (n = 3522; mean age 67.6 years) episodes for the 2 NPWT groups. Wound types differed for NPWT groups (P <.0001) and included surgical (1134 [39%] versus 764 [22%]), generic open (850 [29%] versus 342 [10%]), skin ulcers (561 [19%) versus 1301 [37%]), diabetic ulcers (240 [8%] versus 342 [10%]), and circulatory system wounds (105 [4%) versus 563 [16%]). Average payment amounts were $4650 +/- $2782 for traditional and $1532 +/- $1767 per disposable NPWT episode (P < .0001). Payment differences were not affected by wound or comorbidity characteristics. Using the 2016 rates, average payments were $3501 for traditional and $1564 for disposable NPWT. Considering the rate of NPWT use in the United States and the results of this study suggesting substantial potential cost savings, additional analyses and cost-effectiveness studies are warranted.
C1 [Delhougne, Gary] Smith & Nephew Inc, Hlth Econ, Ft Worth, TX USA.
   [Hogan, Christopher] Direct Res LLC, Vienna, VA USA.
   [Tarka, Kim] Smith & Nephew, Postacute Care, Ft Worth, TX USA.
   [Nair, Sunitha] Presence St Francis Hosp, Wound Healing Ctr, Evanston, IL USA.
C3 Smith & Nephew; Smith & Nephew
RP Delhougne, G (通讯作者)，Smith & Nephew Biotherapeut, 5600 Clearfork Main St,Suite 600, Ft Worth, TX 76109 USA.
EM Gary.Delhougne@Smith-Nephew.com
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
   Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
   Centers for Medicare amd Medicaid Services, HEALTH PEOPL PAY PRO
   Centers for Medicare amd Medicaid Services, CMS1633FC CTR MED ME
   Centers for Medicare amd Medicaid Services, CMS16925F CNT MED ME
   Centers for Medicare amd Medicaid Services, CMS1648F CTR MED MED
   Driver VR, 2016, WOUND REPAIR REGEN, V24, P1041, DOI 10.1111/wrr.12483
   Driver VR, 2014, J AM PODIAT MED ASSN, V104, P147, DOI 10.7547/0003-0538-104.2.147
   Gabriel A, 2013, INT WOUND J, V10, P418, DOI 10.1111/j.1742-481X.2012.00999.x
   Grauhan O, 2013, J THORAC CARDIOV SUR, V145, P1387, DOI 10.1016/j.jtcvs.2012.09.040
   Healthcare Cost and Utilization Project, Healthcare Cost and Utilization Project
   Hurd T, 2014, OSTOMY WOUND MANAG, V60, P30
   Nherera LM, 2017, WOUND REPAIR REGEN, V25, P474, DOI 10.1111/wrr.12530
   Payne Caroline, 2014, Eplasty, V14, pe20
   Rice J Bradford, 2014, J Med Econ, V17, P347, DOI 10.3111/13696998.2014.903258
   Rice JB, 2014, DIABETES CARE, V37, P651, DOI 10.2337/dc13-2176
   Runkel N, 2011, INJURY, V42, pS1, DOI 10.1016/S0020-1383(11)00041-6
   Sen CK, 2009, WOUND REPAIR REGEN, V17, P763, DOI 10.1111/j.1524-475X.2009.00543.x
   Vig S, 2011, J TISSUE VIABILITY, V20, pS1, DOI 10.1016/j.jtv.2011.07.002
NR 20
TC 13
Z9 14
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JAN
PY 2018
VL 64
IS 1
BP 26
EP 33
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GO1CW
UT WOS:000439686000004
PM 29406300
DA 2026-07-24
ER
PT J
AU Cirkovic, I
   Jocic, D
   Bozic, DD
   Djukic, S
   Konstantinovic, N
   Radak, D
AF Cirkovic, Ivana
   Jocic, Dario
   Bozic, Dragana D.
   Djukic, Slobodanka
   Konstantinovic, Neda
   Radak, Djordje
TI The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant
   Staphylococcus aureus Wound Biofilms
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE antibiofilm effect; biofilm; dressing change frequency;
   methicillin-resistant Staphylococcus aureus; MRSA; VAC therapy; wound
   infection
ID NEGATIVE-PRESSURE; INFECTION; RESPONSES
AB Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P < .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P < .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing.
C1 [Cirkovic, Ivana] Univ Belgrade, Inst Microbiol, Microbiol, Belgrade, Serbia.
   [Jocic, Dario] Univ Belgrade, Fac Pharm, Inst Cardiovasc Dis, Belgrade, Serbia.
   [Bozic, Dragana D.] Univ Belgrade, Fac Pharm, Dept Microbiol & Immunol, Microbiol, Belgrade, Serbia.
   [Djukic, Slobodanka] Univ Belgrade, Fac Med, Inst Microbiol & Immunol, Microbiol, Belgrade, Serbia.
   [Konstantinovic, Neda] Univ Belgrade, Fac Med, Inst Microbiol & Immunol, Belgrade, Serbia.
   [Radak, Djordje] Univ Belgrade, Inst Cardiovasc Dis, Vasc Surg, Fac Med, Belgrade, Serbia.
   [Radak, Djordje] Univ Belgrade, Surg, Fac Med, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade
RP Cirkovic, I (通讯作者)，Univ Belgrade, Inst Microbiol, Microbiol, Belgrade, Serbia.
OI Bozic, agana/0000-0002-5373-5540; Cirkovic, Ivana/0000-0003-1515-1824
FU Ministry of Education, Science and Technological Development, Republic
   of Serbia [ON175039]
FX This research was supported by the Ministry of Education, Science and
   Technological Development, Republic of Serbia (project no. ON175039).
   The authors have disclosed no other financial relationships related to
   this article. Submitted July 26, 2017; accepted in revised form January
   2, 2018. Supplemental digital content is available for this article.
   Direct URL citations appear in the printed text and are provided in the
   HTML and PDF versions of this article on the journal's Web site.
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NR 17
TC 3
Z9 6
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2018
VL 31
IS 8
BP 361
EP 364
DI 10.1097/01.ASW.0000540070.07040.70
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA GO4AJ
UT WOS:000439942000005
PM 30028372
DA 2026-07-24
ER
PT J
AU Tamir, E
   Finestone, AS
   Wiser, I
   Anekstein, Y
   Agar, G
AF Tamir, Eran
   Finestone, Aharon S.
   Wiser, Itay
   Anekstein, Yoram
   Agar, Gabriel
TI Outpatient Negative-Pressure Wound Therapy Following Surgical
   Debridement: Results and Complications
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE adverse events; amputation; diabetic foot ulcer; negative-pressure wound
   therapy; neuropathic foot ulcer; osteomyelitis; surgical debridement
ID RANDOMIZED CONTROLLED-TRIAL; FOOT; MULTICENTER; AMPUTATION; ULCERS; CARE
AB OBJECTIVE: To present results and complications in a case series of outpatients with diabetic and neuropathic foot ulcers with exposed bone following surgical debridement treated with negative-pressure wound therapy (NPWT).
   METHODS: Retrospective data were obtained from digital medical records from the Maccabi Health Services High Risk Foot Clinic in Tel Aviv, Israel, between 2009 and 2014. Medical records examined were those of clinic outpatients with exposed bone following partial foot amputation or selective bone debridement (University of Texas grade III-A) treated with NPWT.
   MAIN OUTCOME MEASURES: Wound area, closure rate, and adverse events.
   MAIN RESULTS: There were 66 patients provided NPWT in a total of 77 treatment courses. Mean patient age was 62 +/- 10 years, 82% were male, and mean diabetes mellitus duration was 14 +/- 8 years. Mean HbA1C levels were 8.1% +/- 1.7%. Mean treatment course duration was 16 days (range, 2-42 days). Wound area decreased significantly (from 11.3 +/- 16.8 cm(2) to 8.0 +/- 13.3 cm(2), P < .0001). Ulcer curing was noted in 7% of the cases, and healing progression was noted in 54%. Seven serious adverse events were recorded.
   CONCLUSIONS: Outpatient NPWT is a relatively safe and effective adjuvant to surgical debridement of neuropathic foot ulcers. In an outpatient setting, one can expect serious adverse events to occur in 10% of cases, but this seems unavoidable in patients with diabetic foot ulcers when taking into account their comorbidities and patient resources. Strict protocols to promote early recognition of complications and appropriate response to minimize deterioration must be implemented.
C1 [Tamir, Eran; Agar, Gabriel] Assaf Harofeh Med Ctr, Dept Orthoped, Zerifin, Israel.
   [Finestone, Aharon S.] Assaf Harofeh Med Ctr, Zerifin, Israel.
   [Wiser, Itay] Tel Aviv Univ, Sackler Sch Med, Dept Epidemiol, Tel Aviv, Israel.
   [Anekstein, Yoram] Assaf Harofeh Med Ctr, Orthoped Surg Dept, Spine Unit, Zerifin, Israel.
C3 Tel Aviv University; Shamir Medical Center (Assaf Harofeh); Tel Aviv
   University; Shamir Medical Center (Assaf Harofeh); Tel Aviv University;
   Sackler Faculty of Medicine; Shamir Medical Center (Assaf Harofeh); Tel
   Aviv University
RP Tamir, E (通讯作者)，Assaf Harofeh Med Ctr, Dept Orthoped, Zerifin, Israel.
RI Finestone, Aharon/R-9001-2019; Wiser, Itay/Q-2216-2019
OI Finestone, Aharon/0000-0003-1956-5557; 
CR Allahabadi S, 2016, DIABET FOOT ANKLE, V7, DOI 10.3402/dfa.v7.30079
   [Anonymous], BR J COMMUNITY NURS
   Armstrong David G, 2004, Int J Low Extrem Wounds, V3, P12, DOI 10.1177/1534734604263291
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   Saeed Musab U, 2007, Int J Low Extrem Wounds, V6, P153, DOI 10.1177/1534734607305597
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   Tanaka T, 2016, EUR J PLAST SURG, V39, P247, DOI 10.1007/s00238-016-1200-z
NR 24
TC 10
Z9 12
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2018
VL 31
IS 8
BP 365
EP 369
DI 10.1097/01.ASW.0000531352.93490.24
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA GO4AJ
UT WOS:000439942000006
PM 29649067
DA 2026-07-24
ER
PT J
AU Briceño, E
   Jara, R
AF Briceno, Eduardo
   Jara, Rocio
TI Necrotizing fasciitis caused by a Garengeot's hernia. Case report
SO REVISTA MEDICA DE CHILE
LA Spanish
DT Article
DE Appendicitis; Fasciitis; Necrotizing; Hernia; Femoral; Negative-Pressure
   Wound Therapy
ID FEMORAL HERNIA
AB Garengeot 's hernia corresponds to the presence of the appendix within a femoral hernia, associated or not with acute appendicitis. The diagnosis of this uncommon situation is usually done during surgery. Furthermore, the clinical presentation as necrotizing fasciitis is a rare condition. We report a 54 years old obese hypertensive woman with rheumatoid arthritis of 40 years of evolution treated with methotrexate and prednisone. She consulted for pain and erythema in the right inguinal region. Laboratory revealed leukocytosis and an elevated C-reactive Protein. Suspecting a cellulitis, the patient was admitted for antimicrobial therapy. A pelvic magnetic resonance imaging showed a perforated acute appendicitis in an inguinal hernia with extensive pelvic cellulitis associated with signs of fasciitis. At surgery, an extensive groin and pubic fasciitis was evident, with a necrotic and perforated appendix within a femoral hernia. Surgical debridement, open appendectomy, and femoral hernioplasty without mesh were carried out. Vacuum-assisted closure was installed in the coverage defect. Three surgical debridement procedures were required for the closure of the wound. Two weeks after the first surgical procedure, the patient was discharged in good condition. During the follow-up, she evolved with a surgical wound dehiscence, which was managed with wound dressings until closure.
C1 [Briceno, Eduardo; Jara, Rocio] Pontificia Univ Catolica Chile, Hosp Clin, Dept Cirugia Digest, Santiago, Chile.
C3 Pontificia Universidad Catolica de Chile
RP Briceño, E (通讯作者)，Diagonal Paraguay 362,Piso 4, Santiago, Chile.
EM ebriceno@puc.cl
RI Briceño, Eduardo/AAF-7075-2021
CR Akopian G, 2005, AM SURGEON, V71, P526
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NR 14
TC 0
Z9 2
U1 0
U2 0
PU SOC MEDICA SANTIAGO
PI SANTIAGO 9
PA BERNARDA MORIN 488 PROVIDENCIA, CASILLA 168 CORREO 55, SANTIAGO 9,
   00000, CHILE
SN 0034-9887
EI 0717-6163
J9 REV MED CHILE
JI Rev. Medica Chile
PD MAY
PY 2018
VL 146
IS 5
BP 660
EP 664
DI 10.4067/s0034-98872018000500660
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GO5AA
UT WOS:000440028600014
PM 30148930
OA gold
DA 2026-07-24
ER
PT J
AU Nolff, MC
   Albert, R
   Reese, S
   Meyer-Lindenberg, A
AF Nolff, Mirja C.
   Albert, Rebecca
   Reese, Sven
   Meyer-Lindenberg, Andrea
TI Comparison of Negative Pressure Wound Therapy and Silver-Coated Foam
   Dressings in Open Wound Treatment in Dogs: A Prospective Controlled
   Clinical Trial
SO VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
LA English
DT Article
DE negative pressure wound therapy; polyurethane foam; wound bioburden;
   open wound management; wound; wound planimetry; dog
ID VACUUM-ASSISTED CLOSURE; BLOOD-FLOW; MANAGEMENT; CAT; RECONSTRUCTION;
   PROLIFERATION; GRANULATION; BANDAGES; SKIN; WALL
AB Objectives To evaluate negative pressure wound therapy (NPWT) for treatment of complicated wounds in dogs.
   Study Type Prospective randomized clinical study
   Materials and Methods Dogs (n = 26) undergoing open-wound treatment were randomly assigned to one of two groups: Group A (n = 13) NPWT; Group B (n = 13) silver-coated foam dressing. Pairs of patients were matched based on wound conformation, localization, and underlying cause and compared in terms of duration of previous treatment, development of wound size (wound planimetry), time to closure, bacterial bio-burden and complications. Wound dressing changes were performed every 3 days during the first 9 days of therapy for both groups. Statistical analysis was performed.
   Results Pre-treatment signalment and bacterial status were comparable between groups. Total time to closure was significantly (p = 0.018) shorter in Group A (14.2 days) compared with Group B (28.6 days), and wound planimetry on days 3, 6 and 9 showed significant greater reduction in total wound area for Group A at all-time points (p < 0.05). Furthermore, wounds in Group A showed less progression of local infection than did wounds in Group B (p = 0.01).
   Conclusion NPWT-treated wounds showed faster closure, improved macro-deformation and less local signs of infection.
C1 [Nolff, Mirja C.; Albert, Rebecca; Meyer-Lindenberg, Andrea] Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Dept Clin Vet Med, Munich, Bayern, Germany.
   [Reese, Sven] Ludwig Maximilians Univ Munchen, Dept Basic Vet Sci, Munich, Bayern, Germany.
C3 University of Munich; University of Munich
RP Nolff, MC (通讯作者)，Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Bayern, Germany.
EM m.nolff@lmu.de
RI Nolff, Mirja/W-6756-2019; Reese, Sven/F-1826-2016; Meyer-Lindenberg,
   Andreas/H-1076-2011
OI Nolff, Mirja/0000-0001-9317-7769; Reese, Sven/0000-0002-4605-9791; 
FU Gesellschaft zur Forderung Kynologischer Forschung e.V.
FX The study was partly funded by the 'Gesellschaft zur Forderung
   Kynologischer Forschung e.V'.
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NR 50
TC 14
Z9 19
U1 1
U2 20
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0932-0814
EI 2567-6911
J9 VET COMP ORTHOPAED
JI Vet. Comp. Orthop. Traumatol.
PD JUL
PY 2018
VL 31
IS 4
BP 229
EP 238
DI 10.1055/s-0038-1639579
PG 10
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA GO5BC
UT WOS:000440031700002
PM 29890536
DA 2026-07-24
ER
PT J
AU Tanaydin, V
   Beugels, J
   Andriessen, A
   Sawor, JH
   van der Hulst, RRWJ
AF Tanaydin, V
   Beugels, J.
   Andriessen, A.
   Sawor, J. H.
   van der Hulst, R. R. W. J.
TI Randomized Controlled Study Comparing Disposable Negative-Pressure Wound
   Therapy with Standard Care in Bilateral Breast Reduction Mammoplasty
   Evaluating Surgical Site Complications and Scar Quality
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Negative-pressure therapy; Post-mammoplasty; PICO; Scar; POSAS;
   Cutometer
ID VACUUM-ASSISTED CLOSURE; SKIN ELASTICITY METER; VISUAL ANALOG SCALE;
   CONTROLLED-TRIAL; SATISFACTION; MANAGEMENT; FRACTURES; PATIENT; TRAUMA
AB Background Negative pressure wound therapy (NPWT) for postsurgical incision treatment has demonstrated benefits. A prospective randomized study was developed including 32 patients who underwent bilateral breast reduction mammoplasty. Patients served as their own control and received NPWT to one breast and fixation strips to the other breast.
   Methods The primary outcome was the number of wound healing complications within 21 days when comparing NPWT treatment with fixation strips. The secondary outcome was aesthetic appearance and quality of scarring using questionnaires [visual analogue scale (VAS) and Patient and Observer Scar Assessment Scale (POSAS)] scored at day 42-, 90-, 180- and 365-day follow-up using additional scar measurement modalities, such as viscoelasticity.
   Results For the 32 included patients, the number of wound complications was significantly lower (p < 0.004) for the NPWT treated sites compared to fixation strips. POSAS and VAS scores at 42 and 90 days revealed a significantly better quality of scarring in the NPWT treatment breasts than in fixation strips. At 180-day follow-up, there was a significant improvement in VAS scores, as well as a comparable improvement in POSAS scores. No consistent significant improvement in scar quality was demonstrated with the assays that were used.
   Conclusions Our study showed less complications and a significant improvement in quality of scarring in favor of the NPWT-treated sites. The results indicate NPWT to be an attractive option for these patients.
C1 [Tanaydin, V; Beugels, J.; Sawor, J. H.; van der Hulst, R. R. W. J.] Maastricht Univ, Med Ctr, Maastricht, Netherlands.
   [Andriessen, A.] Andriessen Consultants, Malden, Netherlands.
   [Andriessen, A.] Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands.
   [Sawor, J. H.; van der Hulst, R. R. W. J.] VieCuri Med Ctr, Venlo, Netherlands.
C3 Maastricht University; Radboud University Nijmegen; VieCuri Medical
   Center
RP Tanaydin, V (通讯作者)，Maastricht Univ, Med Ctr, Maastricht, Netherlands.
EM volkan.tanaydin@mumc.nl
FU Smith and Nephew Ltd.
FX This study was funded by Smith and Nephew Ltd., by providing the PICO
   dressings, the Cutometer and financing a research assistant for carrying
   out the assessments and measurements for the study.
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NR 35
TC 50
Z9 55
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD AUG
PY 2018
VL 42
IS 4
BP 927
EP 935
DI 10.1007/s00266-018-1095-0
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GO9AV
UT WOS:000440395700001
PM 29442143
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Iheozor-Ejiofor, Z
   Newton, K
   Dumville, JC
   Costa, ML
   Norman, G
   Bruce, J
AF Iheozor-Ejiofor, Zipporah
   Newton, Katy
   Dumville, Jo C.
   Costa, Matthew L.
   Norman, Gill
   Bruce, Julie
TI Negative pressure wound therapy for open traumatic wounds
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SEVERE OPEN FRACTURES; COST-EFFECTIVENESS;
   MANAGEMENT; STANDARD; TRIAL; NPWT
AB Background
   Traumatic wounds (wounds caused by injury) range from abrasions and minor skin incisions or tears, to wounds with extensive tissue damage or loss as well as damage to bone and internal organs. Two key types of traumatic wounds considered in this review are those that damage soft tissue only and those that involve a broken bone, that is, open fractures. In some cases these wounds are left open and negative pressure wound therapy (NPWT) is used as a treatment. This medical device involves the application of a wound dressing through which negative pressure is applied and tissue fluid drawn away from the area. The treatment aims to support wound management, to prepare wounds for further surgery, to reduce the risk of infection and potentially to reduce time to healing (with or without surgical intervention). There are no systematic reviews assessing the effectiveness of NPWT for traumatic wounds.
   Objectives
   To assess the effects of NPWT for treating open traumatic wounds in people managed in any care setting.
   Search methods
   In June 2018 we searched the Cochrane Wounds Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE (including In-Process & Other Non-Indexed Citations), Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries for ongoing and unpublished studies, and scanned reference lists of relevant included studies as well as reviews, meta-analyses and health technology reports to identify additional studies. There were no restrictions with respect to language, date of publication or study setting.
   Selection criteria
   Published and unpublished randomised controlled trials that used NPWT for open traumatic wounds involving either open fractures or soft tissue wounds. Wound healing, wound infection and adverse events were our primary outcomes.
   Data collection and analysis
   Two review authors independently selected eligible studies, extracted data, carried out a 'Risk of bias' assessment and rated the certainty of the evidence. Data were presented and analysed separately for open fracture wounds and other open traumatic wounds (not involving a broken bone).
   Main results
   Seven RCTs (1377 participants recruited) met the inclusion criteria of this review. Study sample sizes ranged from 40 to 586 participants. One study had three arms, which were all included in the review. Six studies compared NPWT at 125 mmHg with standard care: one of these studies did not report any relevant outcome data. One further study compared NPWT at 75 mmHg with standard care and NPWT 125mmHg with NPWT 75 mmHg.
   Open fracture wounds (four studies all comparing NPWT 125 mmHg with standard care)
   One study (460 participants) comparing NPWT 125 mmHg with standard care reported the proportions of wounds healed in each arm. At six weeks there was no clear difference between groups in the number of participants with a healed, open fracture wound: risk ratio (RR) 1.01 (95% confidence interval (CI) 0.81 to 1.27); moderate-certainty evidence, downgraded for imprecision.
   We pooled data on wound infection from four studies (596 participants). Follow-up varied between studies but was approximately 30 days. On average, it is uncertain whether NPWT at 125 mmHg reduces the risk of wound infection compared with standard care (RR 0.48, 95% CI 0.20 to 1.13; I-2 = 56%); very low-certainty evidence downgraded for risk of bias, inconsistency and imprecision.
   Data from one study shows that there is probably no clear difference in health-related quality of life between participants treated with NPWT 125 mmHg and those treated with standard wound care (EQ-5D utility scores mean difference (MD) -0.01, 95% CI -0.08 to 0.06; 364 participants, moderate-certainty evidence; physical component summary score of the short-form 12 instrument MD -0.50, 95% CI -4.08 to 3.08; 329 participants; low-certainty evidence downgraded for imprecision).
   Moderate-certainty evidence from one trial (460 participants) suggests that NPWT is unlikely to be a cost-effective treatment for open fractures in the UK. On average, NPWT was more costly and conferred few additional quality-adjusted life years (QALYs) when compared with standard care. The incremental cost-effectiveness ratio was GBP 267,910 and NPWT was shown to be unlikely to be cost effective at a range of cost-per-QALYs thresholds. We downgraded the certainty of the evidence for imprecision.
   Other open traumatic wounds (two studies, one comparing NPWT 125 mmHg with standard care and a three-arm study comparing NPWT 125 mmHg, NPWT 75 mmHg and standard care)
   Pooled data from two studies (509 participants) suggests no clear difference in risk of wound infection between open traumatic wounds treated with NPWT at 125 mmHg or standard care (RR 0.61, 95% CI 0.31 to 1.18); low-certainty evidence downgraded for risk of bias and imprecision.
   One trial with 463 participants compared NPWT at 75 mmHg with standard care and with NPWT at 125 mmHg. Data on wound infection were reported for each comparison. It is uncertain if there is a difference in risk of wound infection between NPWT 75 mmHg and standard care (RR 0.44, 95% CI 0.17 to 1.10; 463 participants) and uncertain if there is a difference in risk of wound infection between NPWT 75 mmHg and 125 mmHg (RR 1.04, 95% CI 0.31 to 3.51; 251 participants. We downgraded the certainty of the evidence for risk of bias and imprecision.
   Authors' conclusions
   There is moderate-certainty evidence for no clear difference between NPWT and standard care on the proportion of wounds healed at six weeks for open fracture wounds. There is moderate-certainty evidence that NPWT is not a cost-effective treatment for open fracture wounds. Moderate-certainty evidence means that the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. It is uncertain whether there is a difference in risk of wound infection, adverse events, time to closure or coverage surgery, pain or health-related quality of life between NPWT and standard care for any type of open traumatic wound.
C1 [Iheozor-Ejiofor, Zipporah] Univ Cent Lancashire, Sch Med, Harrington Bldg, Preston, Lancs, England.
   [Newton, Katy] North Western Deanery, Gen Surg, Manchester, Lancs, England.
   [Dumville, Jo C.; Norman, Gill] Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Nursing Midwifery & Social Work, Sch Hlth Sci,Fac Biol Med & Hlth, Manchester, Lancs, England.
   [Costa, Matthew L.] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
   [Bruce, Julie] Univ Warwick, Warwick Clin Trials Unit, Coventry, W Midlands, England.
C3 University of Lancashire; University of Manchester; University of
   Oxford; University of Warwick
RP Iheozor-Ejiofor, Z (通讯作者)，Univ Cent Lancashire, Sch Med, Harrington Bldg, Preston, Lancs, England.
EM ZIheozor-Ejiofor@uclan.ac.uk
RI iheozor-ejiofor, zipporah/N-3012-2013; Bruce, Julie/G-7588-2014; Norman,
   Gill/O-7029-2014; Dumville, Jo/O-7867-2014
OI iheozor-ejiofor, zipporah/0000-0003-2597-3266; Costa,
   Matthew/0000-0003-3644-1388; Bruce, Julie/0000-0002-8462-7999; Norman,
   Gill/0000-0002-3972-5733; Dumville, Jo/0000-0002-6546-3685
FU Division of Nursing Midwifery and Social Work, School of Health
   Sciences, Faculty of Biology, Medicine and Health, University of
   Manchester, UK; National Institute for Health Research (NIHR), UK; NIHR,
   via Cochrane Infrastructure and Cochrane Programme Grant funding (NIHR
   Cochrane Programme Grant) [13/89/08]; National Institute for Health
   Research Collaboration for Leadership in Applied Research and Care (NIHR
   CLAHRC), Greater Manchester, UK; NIHR CLAHRC Greater Manchester; NIHR
   Manchester Biomedical Research Centre, UK; NIHR Manchester Biomedical
   Research Centre; National Institute for Health Research [13/89/08]
   Funding Source: researchfish
FX Internal sourcesDivision of Nursing Midwifery and Social Work, School of
   Health Sciences, Faculty of Biology, Medicine and Health, University of
   Manchester, UK.External sourcesNational Institute for Health Research
   (NIHR), UK.This project was supported by the NIHR, via Cochrane
   Infrastructure and Cochrane Programme Grant funding (NIHR Cochrane
   Programme Grant 13/89/08- High Priority Cochrane Reviews in Wound
   Prevention and Treatment) to Cochrane Wounds. The views and opinions
   expressed therein are those of the authors and do not necessarily
   reflect those of the Systematic Reviews Programme, NIHR, NHS or the
   Department of Health, UK.National Institute for Health Research
   Collaboration for Leadership in Applied Research and Care (NIHR CLAHRC),
   Greater Manchester, UK.Jo Dumville was partly funded by the NIHR CLAHRC
   Greater Manchester. The funder had no role in the design of the studies,
   data collection and analysis, decision to publish, or preparation of the
   manuscript. However, the review may be considered to be affiliated to
   the work of the NIHR CLAHRC Greater Manchester. The views expressed
   herein are those of the authors and not necessarily those of the NHS,
   NIHR or the Department of Health.NIHR Manchester Biomedical Research
   Centre, UK.Jo Dumville and Gill Norman's work on this review was
   co-funded by the NIHR Manchester Biomedical Research Centre. The views
   expressed in this publication are those of the authors and not
   necessarily those of the NHS, the National Institute for Health Research
   or the Department of Health.NIHR Oxford Biomedical Research Centre,
   UK.Matthew Costa's work on this review was funded by the NIHR Oxford
   Biomedical Research Centre. The views expressed in this publication are
   those of the authors and not necessarily those of the NHS, the National
   Institute for Health Research or the Department of Health.
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NR 64
TC 61
Z9 69
U1 2
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2018
IS 7
AR CD012522
DI 10.1002/14651858.CD012522.pub2
PG 71
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GO9HC
UT WOS:000440415900022
OA Green Published, Bronze
DA 2026-07-24
ER
PT J
AU Giannini, S
   Mazzotti, A
   Luciani, D
   Lullini, G
   Tedesco, G
   Andreoli, I
   Cadossi, M
   Faldini, C
AF Giannini, Sandra
   Mazzotti, Antonio
   Luciani, Deianira
   Lullini, Giada
   Tedesco, Giuseppe
   Andreoli, Isabella
   Cadossi, Matteo
   Faldini, Cesare
TI Postoperative wound management with negative pressure wound therapy in
   knee and hip surgery: a randomised control trial
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE ASEPSIS score; negative pressure wound therapy; postoperative wound
   management; standard wound dressing
ID CLOSED SURGICAL INCISIONS; ARTHROPLASTY; SITE; COMPLICATIONS;
   INFECTIONS; FRACTURES; SURVIVAL
AB Objective: To compare the effectiveness in wound healing of negative pressure wound therapy (NPWT) versus a standard dressing in patients who underwent hip or knee revision surgery.
   Method: Participating patients scheduled for hip and knee prosthetic revision were randomised into two groups: one receiving standard povidone-iodine gauze and patch wound dressing (control group) and the other NPWT over the sutured wound area (NPWT group). Patients were evaluated by means of ASEPSIS score, occurrence of blisters, visual analogue scale (VAS) and dressing changes seven days after surgery. We hypothesised a five-point difference in ASEPSIS scores as clinically relevant.
   Results: A total of 110 patients were enrolled in the study. Mean ASEPSIS score was 5.1 for the control group and 3.0 for the NPWT group, with a significant difference in the ASEPSIS score between groups (p<0.001), although this was not clinically relevant. Considering patients with more than three risk factors for healing complication, a statistical difference of >5 points ASEPSIS score was recorded (p<0.0005). Blister occurrence, VAS score and number of dressing changes were significantly lower in the NPWT group.
   Conclusion: The results of this study do not support the routine use of NPWT after hip and knee revision. However, it could be beneficial for selected patients once specific risk factors for wound healing complications have been determined.
C1 [Giannini, Sandra; Mazzotti, Antonio; Lullini, Giada; Cadossi, Matteo; Faldini, Cesare] Univ Bologna, Biomed & Neuromotorial Sci Dept, Bologna, Italy.
   [Mazzotti, Antonio; Luciani, Deianira; Lullini, Giada; Tedesco, Giuseppe; Andreoli, Isabella; Cadossi, Matteo; Faldini, Cesare] Ist Ortoped Rizzoli, Clin Orthopaed & Traumatol, Bologna, Italy.
C3 University of Bologna; IRCCS Istituto Ortopedico Rizzoli
RP Lullini, G (通讯作者)，Univ Bologna, Biomed & Neuromotorial Sci Dept, Bologna, Italy.; Lullini, G (通讯作者)，Ist Ortoped Rizzoli, Clin Orthopaed & Traumatol, Bologna, Italy.
EM Giada.lullini@hotmail.it
RI Tedesco, Giuseppe/K-2495-2018; Mazzotti, Antonio/ABI-2083-2020
OI Tedesco, Giuseppe/0000-0001-8906-3566; 
FU Smith Nephew
FX S.G. worked as a consultant and received honoraria from Smith & Nephew.
   All other authors have no conflict of interests. This study was
   financially supported by Smith & Nephew.
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NR 26
TC 24
Z9 25
U1 0
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2018
VL 27
IS 8
BP 520
EP 525
DI 10.12968/jowc.2018.27.8.520
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GP5VK
UT WOS:000440943300008
PM 30086252
DA 2026-07-24
ER
PT J
AU Ahmed, SS
   Diebold, KE
   Brandvold, JM
   Ewaidah, SS
   Black, S
   Ogundimu, A
   Li, ZY
   Stone, ND
   Van Beneden, CA
AF Ahmed, Sana S.
   Diebold, Kasey E.
   Brandvold, Jacob M.
   Ewaidah, Saadeh S.
   Black, Stephanie
   Ogundimu, Abimbola
   Li, Zhongya
   Stone, Nimalie D.
   Van Beneden, Chris A.
TI The Role of Wound Care in 2 Group A Streptococcal Outbreaks in a Chicago
   Skilled Nursing Facility, 2015-2016
SO OPEN FORUM INFECTIOUS DISEASES
LA English
DT Article
DE group A Streptococcus; healthcare-acquired infection; outbreak; wound
   infection; vacuum-assisted closure
ID UNITED-STATES; EPIDEMIOLOGY
AB Two consecutive outbreaks of group A Streptococcus (GAS) infections occurred from 2015-2016 among residents of a Chicago skilled nursing facility. Evaluation of wound care practices proved crucial for identifying transmission factors and implementing prevention measures. We demonstrated shedding of GAS on settle plates during care of a colonized wound.
C1 [Ahmed, Sana S.] Lake Cty Hlth Dept & Community Hlth Ctr, Communicable Dis, Waukegan, IL USA.
   [Diebold, Kasey E.] Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA.
   [Brandvold, Jacob M.] Washington State Univ, Coll Vet Med, Pullman, WA 99164 USA.
   [Ewaidah, Saadeh S.; Black, Stephanie] Chicago Dept Publ Hlth, Communicable Dis Program, Chicago, IL USA.
   [Ogundimu, Abimbola; Stone, Nimalie D.] Ctr Dis Control & Prevent, Div Hlth Qual & Promot, Atlanta, GA USA.
   [Li, Zhongya] Ctr Dis Control & Prevent, Grp Streptococcus Lab A, Atlanta, GA USA.
   [Van Beneden, Chris A.] Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA USA.
C3 Washington State University; Chicago Department of Public Health;
   Centers for Disease Control & Prevention - USA; Centers for Disease
   Control & Prevention - USA; Centers for Disease Control & Prevention -
   USA
RP Ahmed, SS (通讯作者)，Lake Cty Hlth Dept & Community Hlth Ctr, 3010 Grand Ave, Waukegan, IL 60085 USA.
EM sahmed@lakecountyil.gov
RI Li, Zhongya/JMQ-4363-2023
FU Respiratory Diseases Branch of the Centers for Disease Control and
   Prevention
FX This work was supported by the Respiratory Diseases Branch of the
   Centers for Disease Control and Prevention.
CR [Anonymous], 2015, GUIDELINE ISOLATION
   [Anonymous], GROUP A STREPT GAS D
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NR 11
TC 9
Z9 10
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 2328-8957
J9 OPEN FORUM INFECT DI
JI Open Forum Infect. Dis.
PD JUL
PY 2018
VL 5
IS 7
AR ofy145
DI 10.1093/ofid/ofy145
PG 4
WC Immunology; Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Microbiology
GA GP5YK
UT WOS:000440953400013
PM 30680292
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Beckmann, JH
   Aselmann, H
   Egberts, JH
   Bernsmeier, A
   Laudes, M
   Becker, T
   Schafmayer, C
   Ahrens, M
AF Beckmann, J. H.
   Aselmann, H.
   Egberts, J. H.
   Bernsmeier, A.
   Laudes, M.
   Becker, T.
   Schafmayer, C.
   Ahrens, M.
TI Robot-assisted vs laparoscopic gastric bypass. First experiences with
   the DaVinci system in bariatric surgery
SO CHIRURG
LA German
DT Article
DE Robot assisted surgery; DaVinci; Roux-en-Y gastric bypass; Obesity
   surgery; Postoperative complications
ID PERIOPERATIVE OUTCOMES; METAANALYSIS; OBESITY; COMPLICATIONS; RESECTION
AB Conventional laparoscopy is the gold standard in bariatric surgery. Internationally, robot-assisted surgery is gaining in importance. Up to now there are only few reports from Germany on the use of the system in bariatric surgery. Since January 2017 we have been performing robot-assisted gastric bypass surgery. It remains unclear whether the use of the robotic system has advantages over the well-established laparoscopic technique. Within a period from January to early August 2017 a total of 53 gastric bypass operations were performed. Of these 16 proximal redo Roux-en-Y gastric bypass operations were performed with the DaVinci Si system versus 29 laparoscopic procedures. A retrospective analysis of the perioperative course was carried out. Body weight, body mass index (BMI), Edmonton obesity staging system (EOSS) and American Society of Anesthesiologists (ASA) classification did not show significant differences. There were also no significant differences in terms of estimated blood loss, intraoperative complications, duration of surgery, postoperative inflammatory parameters and weight loss. There was no mortality and no need for revisional surgery in either group. After laparoscopic surgery there was a delayed occurrence of a leak of the gastrojejunostomy followed by readmission and endoscopic negative pressure wound therapy. The results show that the proximal Roux-en-Y gastric bypass can be performed safely and efficiently using the DaVinci surgical system. Significant differences to the conventional laparoscopic procedure were not found. Larger randomized controlled trials are needed to define the role of the DaVinci system in bariatric surgery.
C1 [Beckmann, J. H.; Aselmann, H.; Egberts, J. H.; Bernsmeier, A.; Becker, T.; Schafmayer, C.; Ahrens, M.] Univ Klinikum Schleswig Holstein, Klin Allgemeine Viszeral Transplantat Thorax & Ki, Campus Kiel,Arnold Heller Str 3, D-24105 Kiel, Germany.
   [Laudes, M.] Univ Klinikum Schleswig Holstein, Klin Innere Med 1, Campus Kiel, Kiel, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; University
   of Kiel; Schleswig Holstein University Hospital
RP Beckmann, JH (通讯作者)，Univ Klinikum Schleswig Holstein, Klin Allgemeine Viszeral Transplantat Thorax & Ki, Campus Kiel,Arnold Heller Str 3, D-24105 Kiel, Germany.
EM jan.beckmann@uksh.de
RI Beckmann, Jan/AAG-3099-2021; Laudes, Matthias/C-8885-2011; Egberts,
   Jan-Hendrik/E-3211-2015
OI Beckmann, Jan/0000-0002-8069-6786; 
CR Ahmad A, 2016, SURG ENDOSC, V30, P3792, DOI 10.1007/s00464-015-4675-y
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   Tian HL, 2011, OBES REV, V12, P254, DOI 10.1111/j.1467-789X.2010.00757.x
NR 19
TC 4
Z9 4
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD AUG
PY 2018
VL 89
IS 8
BP 612
EP 620
DI 10.1007/s00104-018-0629-y
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GP7QX
UT WOS:000441100600007
PM 29589076
DA 2026-07-24
ER
PT J
AU Nam, D
   Sershon, RA
   Levine, BR
   Della Valle, CJ
AF Nam, Denis
   Sershon, Robert A.
   Levine, Brett R.
   Della Valle, Craig J.
TI The Use of Closed Incision Negative-Pressure Wound Therapy in
   Orthopaedic Surgery
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; CARE-ASSOCIATED INFECTIONS; SURGICAL SITE
   INFECTIONS; TOTAL KNEE ARTHROPLASTY; THICKNESS SKIN-GRAFTS; JOINT
   ARTHROPLASTY; MANAGEMENT-SYSTEM; FINANCIAL IMPACT; HIP-ARTHROPLASTY;
   CONTROLLED-TRIAL
AB Wound complications and surgical site infections after orthopaedic procedures result in substantial morbidity and costs. Traditional postoperative wound care consists of applying sterile, dry gauze and abdominal pads to the surgical site, with more frequent dressing changes performed in cases in which wound drainage is excessive. Persistent incisional drainage is of particular concern because it increases the risk of deep infection. The use of closed incision negative-pressure wound therapy (ciNPWT) to manage delayed wound healing was first reported a decade ago, and the benefits of this treatment modality include wound contraction with diminished tensile forces, stabilization of the wound environment, decreased edema and improved removal of exudate, and increased blood and lymphatic flow. Numerous trauma, plastic surgery, and general surgery studies have demonstrated that ciNPWT improves wound healing. In orthopaedic surgery, ciNPWT has been shown to be clinically effective for incisions at high risk for perioperative complications. However, specific indications for ciNPWT continue to be defined.
C1 [Nam, Denis; Sershon, Robert A.; Levine, Brett R.; Della Valle, Craig J.] Rush Univ, Med Ctr, Dept Orthopaed Surg, Chicago, IL 60612 USA.
C3 Rush University
RP Nam, D (通讯作者)，Rush Univ, Med Ctr, Dept Orthopaed Surg, Chicago, IL 60612 USA.
RI ; Levine, Brett/AAE-1963-2019
OI Sershon, Robert/0000-0002-2566-1871; 
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NR 49
TC 52
Z9 61
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD MAY 1
PY 2018
VL 26
IS 9
BP 295
EP 302
DI 10.5435/JAAOS-D-17-00054
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA GP9CU
UT WOS:000441215400004
PM 29620609
DA 2026-07-24
ER
PT J
AU Wang, GQ
   Li, ZR
   Wang, S
   Li, TT
   Zhang, LH
   Zhang, LC
   Tang, PF
AF Wang Guoqi
   Li Zhirui
   Wang Song
   Li Tongtong
   Zhang Lihai
   Zhang Licheng
   Tang Peifu
TI Negative pressure wound therapy reduces the motility of Pseudomonas
   aeruginosa and enhances wound healing in a rabbit ear biofilm
   infection model
SO ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR
   MICROBIOLOGY
LA English
DT Article
DE Negative pressure wound therapy; Infection; Virulence factor; Biofilm;
   Wound
ID BACTERIAL BIOFILMS; IN-VIVO; STAPHYLOCOCCUS-AUREUS; POTENTIAL ROLE;
   SKIN; ELASTASE; GROWTH; MECHANISMS; STRATEGIES; ANTIBODIES
AB Pseudomonas aeruginosa motility, virulence factors and biofilms are known to be detrimental to wound healing. The efficacy of negative pressure wound therapy (NPWT) against P. aeruginosa has been little studied, either in vitro or in vivo. The present study evaluated the effect of negative pressure (NP) on P. aeruginosa motility in vitro, and the effect of NPWT on virulence factors and biofilms in vivo. P. aeruginosa motility was quantified under different levels of NP (atmospheric pressure, - 75, - 125, - 200 mmHg) using an in vitro model. Swimming, swarming and twitching motility were significantly inhibited by NP (- 125 and - 200 mmHg) compared with atmospheric pressure (p = 0.05). Virulence factors and biofilm components were quantified in NPWT and gauze treated groups using a rabbit ear biofilm model. Biofilm structure was studied with fluorescence microscopy and scanning electron microscopy. Additionally, viable bacterial counts and histological wound healing parameters were measured. Compared with the control, NPWT treatment resulted in a significant reduction in expression of all virulence factors assayed including exotoxin A, rhamnolipid and elastase (p = 0.01). A significant reduction of biofilm components (eDNA) (p = 0.01) was also observed in the NPWT group. The reduction of biofilm matrix was verified by fluorescence- and scanning electron-microscopy. NPWT lead to better histologic parameters (p = 0.01) and decreased bacterial counts (p = 0.05) compared with the control. NPWT treatment was demonstrated to be an effective strategy to reduce virulence factors and biofilm components, which may explain the increased wound healing observed.
C1 [Wang Guoqi; Li Zhirui; Zhang Lihai; Zhang Licheng; Tang Peifu] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [Wang Song] Nankai Univ, Med Coll, Tianjin 300071, Peoples R China.
   [Li Tongtong] Tianjin Hosp, Dept Orthoped, 406 Jiefangnan Rd, Tianjin 300211, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Nankai University;
   Tianjin University
RP Zhang, LC; Tang, PF (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM guoqi71@126.com; lzr860514@163.com; mrwangsng@163.com; li_cucu@163.com;
   zhanglihai301@gmail.com; zhanglcheng218@126.com; pftang301@163.com
RI Li, Zhirui/OJT-0490-2025
FU National Natural Science Foundation of China [81472112]
FX This study was supported by National Natural Science Foundation of China
   (No. 81472112).
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NR 53
TC 20
Z9 21
U1 0
U2 36
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0003-6072
EI 1572-9699
J9 ANTON LEEUW INT J G
JI Antonie Van Leeuwenhoek
PD SEP
PY 2018
VL 111
IS 9
BP 1557
EP 1570
DI 10.1007/s10482-018-1045-5
PG 14
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA GQ5MR
UT WOS:000441729300006
PM 29468490
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Jorgensen, MG
   Toyserkani, NM
   Hyldig, N
   Chakera, AH
   Hölmich, LR
   Thomsen, JB
   Sorensen, JA
AF Jorgensen, Mads Gustaf
   Toyserkani, Navid Mohammadpour
   Hyldig, Nana
   Chakera, Annette Hougaard
   Holmich, Lisbet Rosenkrantz
   Thomsen, Jorn Bo
   Sorensen, Jens Ahm
TI Prevention of seroma following inguinal lymph node dissection with
   prophylactic, incisional, negative-pressure wound therapy (SEROMA
   trial): study protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Prevention; Negative-pressure wound therapy; Seroma; Surgical-site
   infection; Lymphedema; Lymph node dissection; Melanoma
AB Background: Radical inguinal lymphadenectomy (ILND) for metastatic melanoma is associated with a high complication rate. Seroma is often the first postoperative complication, followed by prolonged wound healing sometimes requiring reoperation, infection, multiple outpatient visits and re-hospitalization. Prevention of seroma may, therefore, lead to a reduction in many of the other complications.
   Methods/design: The primary aim of this randomized study is to investigate whether fewer patients require treatment for seroma by immediate prophylactic application of incisional, Negative-pressure Wound Therapy (iNPWT) following ILND, compared to standard postoperative treatment The secondary outcomes include surgical-site infection, dehiscence, hematoma, length of hospitalization, quality of life, safety, long-term assessment of lymphedema and non-inferiority oncological outcome. Data will be registered prospectively at check-ups after 7 and 14 days, 1 and 3 months and 2 years after inguinal lymphadenectomy using case report forms and questionnaires and stored in a secure online database.
   Discussion: To our knowledge, this trial is the first randomized study evaluating negative-pressure wound therapy as a prophylactic intervention for complications following melanoma-related ILND. The results from this trial will hopefully determine the efficacy and safety of prophylactic iNPWT treatment in prevention of the clinical relevant short- and long-term postoperative complications following ILND and may provide an evidence base for the an improved postoperative regimen.
C1 [Jorgensen, Mads Gustaf; Toyserkani, Navid Mohammadpour; Thomsen, Jorn Bo; Sorensen, Jens Ahm] Odense Univ Hosp, Dept Plast Surg, Sdr Blvd 29, DK-5000 Odense, Denmark.
   [Hyldig, Nana] Odense Univ Hosp, Hans Christian Andersens Children Hosp, Odense, Denmark.
   [Chakera, Annette Hougaard; Holmich, Lisbet Rosenkrantz] Herlev Gentofte Hosp, Dept Plast Surg, Herlev, Denmark.
   [Toyserkani, Navid Mohammadpour] Roskilde Hosp, Dept Plast Surg, Roskilde, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital
RP Sorensen, JA (通讯作者)，Odense Univ Hosp, Dept Plast Surg, Sdr Blvd 29, DK-5000 Odense, Denmark.
EM jens.sorensen@rsyd.dk
RI ; Sørensen, Jens Ahm/D-6279-2014; Hölmich, Lisbet/P-1614-2018; Hyldig,
   Nana/AAH-5220-2020
OI Chakera, Annette Hougaard/0000-0002-3859-0814; Sørensen, Jens
   Ahm/0000-0003-4903-0094; Jørgensen, Mads Gustaf/0000-0002-8755-3446;
   Hyldig, Nana/0000-0001-6758-6294
FU company SmithNephew
FX The iNPWT devices used in this study have been granted to JAS by the
   company Smith&Nephew. The grant is of unrestricted nature and the grant
   provider has no influence on the study design, data collection, data
   analysis, interpretation of results or writing of the report.
CR Agrawal A, 2006, ANZ J SURG, V76, P1088, DOI 10.1111/j.1445-2197.2006.03949.x
   [Anonymous], 2013, LYMPHOLOGY, V46, P1
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   Jorgensen MG, 2018, MICROSURG, V38, P576, DOI 10.1002/micr.30180
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NR 26
TC 11
Z9 15
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD AUG 15
PY 2018
VL 19
AR 441
DI 10.1186/s13063-018-2757-6
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GQ6OX
UT WOS:000441839900001
PM 30111378
OA Green Submitted, Green Published, Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Mijatovic, D
   Orehovec, SS
   Dapic, T
   Mijatovic, VV
   Mance, M
AF Mijatovic, Davor
   Orehovec, Sanda Smud
   Dapic, Tomislav
   Mijatovic, Vilena Vrbanovic
   Mance, Marko
TI Management of a Complex Lower Limb Open Fracture in a Teenage Patient: A
   Case Report
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case study; tibial fracture; adolescent; limb salvage; reconstructive
   surgical procedures
ID PEDIATRIC POPULATION; TIBIAL FRACTURES; CHILDREN
AB The challenges of managing Gustilo IIIB tibial fractures (ie, high energy trauma with a contaminated wound >10 cm in length, severe comminution ["crumbling"] or segmental fractures, and periosteal stripping) children are unique in part because no clear guidelines exist and the injuries may cause short-term and long-term complications. Repeated wound debridement and secondary reconstruction are required in approximately 20% of these cases in both adults and children. A 13-year-old girl presented with severe polytrauma including an open Gustilo type IIIB fracture of the left lower leg. The patient declined limb amputation; a multidisciplinary team (plastic, pediatric, orthopedic-trauma surgeons, pediatrician, psychiatrist, clinical pharmacologist, anesthesiologist, physiotherapist, nurses) was assembled in order to give the patient the best chance of a successful outcome. Multiple limb salvage and reconstructive procedures including wound debridements, necrectomies, long-term negative pressure wound therapy, soft tissue reconstructions, a external bone fixation, bone osteosynthesis, multiple skin grafts, and free-flap reconstruction were provided over a period of 6 months with great success. The patient is doing well 3 years after initial injury and is walking without , complications. A multidisciplinary approach and structured treatment plan are important to minimize complications, avoid necessary delays in app roach morbidity, and provide the patient with the best result possible. Studies examining optimal treatment treatment strategies for children and adolescents with these complicated fractures are needed.
C1 [Mijatovic, Davor] Univ Zagreb, Sch Med, Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.
   [Mijatovic, Davor] Univ Hosp Ctr, Plast Reconstruct & Aesthet Surg Ward, Zagreb, Croatia.
   [Orehovec, Sanda Smud] Univ Hosp Ctr, Zagreb, Croatia.
   [Dapic, Tomislav] Univ Zagreb, Sch Med, Orthoped Surg, Zagreb, Croatia.
   [Dapic, Tomislav] Univ Hosp Ctr, Dept Orthopaed Surg, Zagreb, Croatia.
   [Mijatovic, Vilena Vrbanovic] Clin Hosp Ctr, Anesthesiol & Reanamatol, Dept Anesthesiol, Zagreb, Croatia.
   [Mance, Marko] Univ Hosp Ctr, Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.
C3 University of Zagreb; University of Zagreb; University of Zagreb;
   University of Zagreb; University of Zagreb; University of Zagreb
RP Orehovec, SS (通讯作者)，Clin Hosp Ctr, Dept Surg, Div Plast Reconstruct & Breast Surg, Kispaticeva 12, Zagreb 10000, Croatia.
EM sanda.smud@gmail.com
OI Vrbanović Mijatović, Vilena/0000-0001-8568-1359
CR Baldwin KD, 2009, J CHILD ORTHOP, V3, P199, DOI 10.1007/s11832-009-0169-6
   Bartlett CS, 1997, J ORTHOP TRAUMA, V11, P357, DOI 10.1097/00005131-199707000-00010
   Glass GE, 2009, INJURY, V40, P876, DOI 10.1016/j.injury.2008.12.010
   Gougoulias N, 2009, BRIT MED BULL, V91, P75, DOI 10.1093/bmb/ldp019
   GUSTILO RB, 1984, J TRAUMA, V24, P742, DOI 10.1097/00005373-198408000-00009
   GUSTILO RB, 1976, J BONE JOINT SURG AM, V58, P453, DOI 10.2106/00004623-197658040-00004
   GUSTILO RB, 1990, J BONE JOINT SURG AM, V72A, P299, DOI 10.2106/00004623-199072020-00023
   Moore Zena, 2014, J Wound Care, V23 Suppl 5b, pS1, DOI 10.12968/jowc.2014.23.Sup5b.S1
   Palmu SA, 2014, ACTA ORTHOP, V85, P513, DOI 10.3109/17453674.2014.916489
   Ruedi T, 2007, AO PRINCIPLES FRACTU, V1, P96
   Setter KJ, 2006, CURR OPIN PEDIATR, V18, P30, DOI 10.1097/01.mop.0001110936.81101.c3
NR 11
TC 2
Z9 2
U1 0
U2 10
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAY
PY 2018
VL 64
IS 5
BP 47
EP 52
DI 10.25270/owm.2018.5.4752
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GQ6XD
UT WOS:000441871700007
PM 29847311
DA 2026-07-24
ER
PT J
AU Janowska, A
   Oranges, T
   Chiricozzi, A
   Romanelli, M
   Dini, V
AF Janowska, Agata
   Oranges, Teresa
   Chiricozzi, Andrea
   Romanelli, Marco
   Dini, Valentina
TI Synergism of Therapies After Postoperative Autograft Failure in a
   Patient With Melanoma of the Foot Misdiagnosed as a Pressure Ulcer
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE CELLUTOME; epidermal skin grafting; melanoma; foot; autograft
AB Introduction: Amelanotic melanoma of the foot is a diagnostic challenge for physicians as it often appears as a benign lesion. In order to make the correct diagnosis at early stages, it is recommended to perform a biopsy of worsening lesions that are refractory to standard treatments, particularly nonhealing wounds. Case report: The authors describe the case of a 57-year-old man with amelanotic melanoma of the foot that had been treated as a pressure ulcer for 3 months. He underwent wide local excision of the melanoma and an application of skin autograft. After skin autograft failure, optimal wound bed preparation was achieved through negative pressure wound therapy and compression bandages associated with hyperbaric therapy. Complete wound healing was obtained with an epidermal fractional skin grafting system combined with compressive inelastic bandages. Conclusions: Physicians must remain highly cautious of ulcerated lesions of the foot and may consider epidermal fractional skin grafting as a valid therapeutic option in case of postsurgical wounds resulting from wide local excision of malignant melanomas.
C1 [Janowska, Agata; Oranges, Teresa; Chiricozzi, Andrea; Romanelli, Marco; Dini, Valentina] Univ Pisa, Dept Dermatol, Wound Healing Res Unit, Pisa, Italy.
C3 University of Pisa
RP Janowska, A (通讯作者)，Univ Pisa, Dept Dermatol, Via Roma 67, I-56124 Pisa, Italy.
EM dottoressajanowska@gmail.com
RI Chiricozzi, Andrea/AAC-3343-2019; Janowska, Agata/HHS-7036-2022;
   Oranges, Teresa/AAM-9690-2020; dini, valentina/F-7747-2017
OI Janowska, Agata/0000-0002-2271-3859; Oranges,
   Teresa/0000-0002-7277-3278; dini, valentina/0000-0002-8537-1999
CR Bristow I, 2016, CLIN PODIATR MED SUR, V33, P409, DOI 10.1016/j.cpm.2016.02.008
   Cai SS, 2016, CUREUS J MED SCIENCE, V8, DOI 10.7759/cureus.853
   Gualandri L, 2009, J EUR ACAD DERMATOL, V23, P283, DOI 10.1111/j.1468-3083.2008.03041.x
   Howarth Ashley L, 2015, Burns, V41, pe57, DOI [10.1016/j.burns.2015.02.021, 10.1016/j.burns.2015.02.021]
   Janowska A, 2016, INT WOUND J, V13, P47, DOI 10.1111/iwj.12632
   Osborne SN, 2016, ADV SKIN WOUND CARE, V29, P57, DOI 10.1097/01.ASW.0000476072.88818.aa
   Romanelli M, 2015, BRIT J DERMATOL, V172, P853, DOI 10.1111/bjd.13580
   Shaikh WR, 2012, ARCH DERMATOL, V148, P30, DOI 10.1001/archdermatol.2011.264
   Smith OJ, 2017, INT WOUND J, V14, P555, DOI 10.1111/iwj.12644
   Yin NC, 2013, INT J LOW EXTR WOUND, V12, P289, DOI 10.1177/1534734613512505
NR 10
TC 5
Z9 5
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2018
VL 30
IS 4
BP E41
EP E43
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GQ7HI
UT WOS:000441907100002
PM 29718821
DA 2026-07-24
ER
PT J
AU McGinness, K
   Phelan, DHK
AF McGinness, Kristen
   Phelan, Dorothy H. Kurtz
TI Use of Viable Cryopreserved Umbilical Tissue for Soft Tissue Defects in
   Patients With Gas Gangrene: A Case Series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE gas gangrene; viable cryopreserved umbilical tissue; surgical; placental
   tissue; amputation
ID DIABETIC FOOT ULCERS; AMNIOTIC MEMBRANE; CLOSURE; CELLS
AB Introduction: Gas gangrene is a rapidly progressive bacterial infection leading to necrosis that usually develops as a result of trauma or postoperative complications. This condition requires early diagnosis with immediate surgical intervention. With a poor prognosis, a high incidence of amputation, and comorbidities such as diabetes and peripheral vascular disease, patients with gas gangrene are put at further risk for surgical complications. Objective: This case series reports the clinical outcomes of using a commercially available viable cryopreserved umbilical tissue (vCUT) in the surgical management of 10 patients (9 males, 1 female) with acute lower extremity gas gangrene. Materials and methods: All 10 patients had aggressive debridement and irrigation, followed by an intraoperative application of vCUT to cover the large, complex wounds with exposed bone, tendon, and soft tissue, which was fenestrated and sutured to the surrounding skin edges. Results: The average wound size following debridement was 45.9 cm2 (range, 8 cm2-105 cm2). Average percent area reduction of the wounds at 4 weeks post-vCUT application was 68.4% (range, 49%-99.5%). The average length of hospital stay was 9 days (range, 2-16 days), and postdischarge patients were treated with negative pressure wound therapy and standard of care (nonadherent dressing, dry gauze, and mild compression) until wound closure was achieved (average, 3.3 months [range, 1.25-4.5 months]). With a 1-time application of vCUT, all patients reached complete wound closure with decreased time to closure, fewer complications, and a shorter duration of hospitalization as compared with traditional inpatient management of gas gangrene (incision and drainage with staged procedures). Conclusions: The positive clinical outcomes indicate that vCUT may be an effective aid as an intraoperative application to cover wounds following aggressive debridement in the presence of gas gangrene.
C1 [McGinness, Kristen] Yale New Haven Northeast Med Grp Podiatry, Greenwich, CT USA.
   [Phelan, Dorothy H. Kurtz] Osiris Therapeut Inc, Columbia, MD USA.
C3 Osiris Therapeutics
RP Phelan, DHK (通讯作者)，Osiris Therapeut Inc, Dept Med Affairs, 7015 Albert Einstein Dr, Columbia, MD 21046 USA.
EM dphelan@osiris.com
FU Osiris Therapeutics, Inc.
FX Dr. Kurtz Phelan is a paid employee of Osiris Therapeutics, Inc.
   Manuscript production support was provided by Osiris Therapeutics, Inc.
CR Aggelidakis J, 2011, WORLD J EMERG SURG, V6, DOI 10.1186/1749-7922-6-28
   Armstrong DG, 2013, DIABETES CARE, V36, P1815, DOI 10.2337/dc12-2285
   Duan-Arnold Y, 2015, ADV WOUND CARE, V4, P523, DOI 10.1089/wound.2015.0636
   Duan-Arnold Y, 2015, ADV WOUND CARE, V4, P513, DOI 10.1089/wound.2015.0638
   Duan-Arnold Y, 2015, ADV WOUND CARE, V4, P329, DOI 10.1089/wound.2015.0637
   Fincke BG, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-192
   Frykberg RG, 2017, INT WOUND J, V14, P569, DOI 10.1111/iwj.12649
   Frykberg RG, 2015, ADV SKIN WOUND CARE, V28, P17, DOI 10.1097/01.ASW.0000456630.12766.e9
   Lavery LA, 2014, INT WOUND J, V11, P554, DOI 10.1111/iwj.12329
   Margolis DJ., 2011, INCIDENCE DIABETIC F
   Moxey PW, 2011, DIABETIC MED, V28, P1144, DOI 10.1111/j.1464-5491.2011.03279.x
   Niknejad H, 2008, EUR CELLS MATER, V15, P88
   Stankiewicz M, 2015, DERMATOL SURG, V41, P775, DOI 10.1097/DSS.0000000000000391
   Suzuki K, 2016, J WOUND CARE, V25, pS25, DOI 10.12968/jowc.2016.25.Sup10.S25
   Yamaguchi Y, 2004, BRIT J DERMATOL, V151, P1019, DOI 10.1111/j.1365-2133.2004.06170.x
NR 15
TC 9
Z9 10
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2018
VL 30
IS 4
BP 90
EP 95
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GQ7HI
UT WOS:000441907100006
PM 29718818
DA 2026-07-24
ER
PT J
AU Griffin, L
   Casillas, LML
AF Griffin, Leah
   Casillas, Laura M. Leyva
TI A Patient-centered Remote Therapy Monitoring Program Focusing on
   Increased Adherence to Wound Therapy: A Large Cohort Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE remote therapy monitoring; Negative Pressure Wound Theraov; patient
   adherence
AB Objective. This retrospective study of 510 patients receiving negative pressure wound therapy (NPWT) in a home care setting examines the relationship between remote therapy monitoring (RTM) and patient adherence, as well as determines the impact of patient adherence on wound progression. Materials and Methods. Adherence to treatment was continuously monitored via RTM, and patients with therapy usage < 16 hours in 1 day received an adherence call. Repeated failures to reach a noncompliant patient led to an escalation call to the caregiver to discuss treatment. Wound volume and surface area were collected to determine the rate of wound size reduction. Results. A total of 3261 calls were made with an average of 6.4 calls per patient. Among the 510 patients, 98% received a welcome call, 87% received at least 1 call due to low adherence, and 30% received an escalation call. The day following an adherence call, 73.5% of patients increased therapy use. As adherence to NPWT increased (< 60% to 90%-100% therapy use), there was an increase in the daily reduction rate in wound volume (1.42% to 2.23%) and surface area (0.86% to 1.45%). Conclusions. The data suggest RTM can be used to influence patient behavior, and there may be a potential relationship between patient behavior and wound healing outcomes. Additional studies are needed to elucidate the relationship between RTM and wound outcomes.
C1 [Griffin, Leah; Casillas, Laura M. Leyva] Acelity, 12930 W Interstate 10, San Antonio, TX 78249 USA.
RP Griffin, L (通讯作者)，Acelity, 12930 W Interstate 10, San Antonio, TX 78249 USA.
EM Leah.Griffin@Acelity.com
FU KCI, an Acelity Company
FX The authors are employees of Acelity, San Antonio, TX. Financial support
   for this research was provided by KCI, an Acelity Company. Mikaela
   Sifuentes, PhD (Acelity), provided medical writing support. Data were
   presented at the 2018 Symposium on Advanced Wound Care Spring in
   Charlotte, NC.
NR 0
TC 8
Z9 9
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2018
VL 30
IS 8
BP E81
EP E82
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GQ7IH
UT WOS:000441910800003
PM 30212369
DA 2026-07-24
ER
PT J
AU Wang, Z
   Bai, M
   Zeng, A
   Liu, ZF
   Zhao, R
   Wang, XJ
AF Wang, Zhi
   Bai, Ming
   Zeng, Ang
   Liu, Zhifei
   Zhao, Ru
   Wang, Xiaojun
TI The Role of Negative Pressure Wound Therapy in Managing Chinese Patients
   With Wound derived Acute Severe Illness
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE emergency service; hospital; negative pressure wound therapy; salvage
   therapy; shock; septic; wound healing; acute
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE; INJURY
AB Introduction. Resulting mostly from major injury or infection, severe acute wounds are often accompanied by septic shock or multiple organ failure and associated with high disability and mortality rates. In managing Chinese patients with wound-derived acute severe illnesses, salvage treatment in the emergency department has traditionally prioritized life support and protection of vital organs before wound repair. Objective. This retrospective review evaluated the outcomes of patients with wound-derived acute severe illness who were treated with a new salvage protocol that combined proactive wound care with simultaneous life-support measures. Materials and Methods. Records from 2011 to 2013 at Peking Union Medical College Hospital (PUMCH) in Beijing, China, were reviewed to identify patients with wound-derived acute severe illness treated with the new protocol. The plastic surgery department, emergency department, and intensive care unit developed the protocol, which included proactive wound treatment with negative pressure wound therapy (NPWT), interdepartmental cooperation, and comprehensive patient treatment. Results. Fifty-six patients were managed with the new protocol. At presentation, all patients were in septic shock and 29 of 56 (51.8%) required mechanical ventilation. Of the treated patients, 21 (37.5%) fully recovered and 29 (51.8%) improved sufficiently enough for transfer to a general ward. Six patients (10.7%) died of causes unrelated to NPWT. Conclusions. At PUMCH, the new collaborative salvage protocol with proactive use of NPWT with simultaneous life-support methods resulted in greater therapeutic effects than traditional salvage treatment could offer.
C1 [Wang, Zhi; Bai, Ming; Zeng, Ang; Liu, Zhifei; Zhao, Ru; Wang, Xiaojun] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital
RP Wang, XJ (通讯作者)，Peking Union Med Coll Hosp East, 1 Shuaifuyuan Wangfujing, Beijing 100730, Peoples R China.
EM pumchwxj@163.com
RI 龙, 笑/GPW-6382-2022; /AAT-4908-2020; wang, xiaojun/NFT-0476-2025
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NR 14
TC 1
Z9 2
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2018
VL 30
IS 8
BP 235
EP 241
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GQ7IH
UT WOS:000441910800008
PM 30212366
DA 2026-07-24
ER
PT J
AU Deng, CL
   Wang, LY
   Feng, JW
   Lu, F
AF Deng, Chengliang
   Wang, Liangyue
   Feng, Jingwei
   Lu, Feng
TI Treatment of human chronic wounds with autologous extracellular
   matrix/stromal vascular fraction gel: A STROBE-compliant study
SO MEDICINE
LA English
DT Article
DE adipose-derived stem cell; extracellular matrix; negative pressure wound
   therapy; stromal vascular fraction; wound healing
ID MESENCHYMAL STEM-CELLS; VENOUS LEG ULCERS; ADIPOSE; THERAPY; SKIN; RAT;
   DIFFERENTIATION; THERAPEUTICS; REGENERATION; PROGENITOR
AB Stem cell therapy is considered as the most promising treatment for chronic wounds. Extracellular matrix/stromal vascular fraction gel (ECM/SVF gel), an adipose-derived stem cell-based cytotherapy, has shown healing potential in experimental wounds in animal models. However, the effects of ECM/SVF gel on human chronic wounds have not been investigated. The aim of the present study is to investigate the therapeutic effect of ECM/SVF gel on human chronic wounds.Autologous ECM/SVF gel was prepared and used to treat patients with chronic wounds in clinics, with negative pressure wound therapy as the positive control. Wound healing rate per week and histological changes were performed.The average wound healing rate per week in the ECM/SVF gel group was 34.5511.18% compared with 10.16 +/- 2.67% in the negative pressure wound therapy group (P<.001). Histological analysis with hematoxylin and eosin, Masson's trichrome staining, and CD31 immunohistochemistry showed less lymphocyte infiltration, more collagen accumulation, and more newly formed vessels in the ECM/SVF gel group treated skins compared to the control.ECM/SVF gel is an effective therapeutic option for chronic wound healing in clinics.
C1 [Deng, Chengliang] Zunyi Med Coll, Affiliated Hosp, Dept Plast Surg, Zunyi, Guizhou, Peoples R China.
   [Deng, Chengliang; Wang, Liangyue; Feng, Jingwei; Lu, Feng] Southern Med Univ, Nanfang Hosp, Dept Plast Surg, 1838 Guangzhou North Rd, Guangzhou 510515, Guangdong, Peoples R China.
C3 Zunyi Medical University; Southern Medical University - China
RP Lu, F (通讯作者)，Southern Med Univ, Nanfang Hosp, Dept Plast Surg, 1838 Guangzhou North Rd, Guangzhou 510515, Guangdong, Peoples R China.
EM doctorlufeng@hotmail.com
FU National Nature Science Foundation of China [81471881, 81660323]
FX This work is supported by National Nature Science Foundation of China
   (81471881, 81660323).
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NR 44
TC 47
Z9 63
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG
PY 2018
VL 97
IS 32
AR e11667
DI 10.1097/MD.0000000000011667
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GR0ZJ
UT WOS:000442254400014
PM 30095623
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wihbey, KA
   Joyce, EM
   Spalding, ZT
   Jones, HJ
   MacKenzie, TA
   Evans, RH
   Fung, JL
   Goldman, MB
   Erekson, E
AF Wihbey, Kristina A.
   Joyce, Ellen M.
   Spalding, Zachary T.
   Jones, Hayley J.
   MacKenzie, Todd A.
   Evans, Rebecca H.
   Fung, June L.
   Goldman, Marlene B.
   Erekson, Elisabeth
TI Prophylactic Negative Pressure Wound Therapy and Wound Complication
   After Cesarean Delivery in Women With Class II or III Obesity A
   Randomized Controlled Trial
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID RISK
AB OBJECTIVE: To compare the occurrence of superficial surgical site infections in obese women using prophylactic negative pressure therapy with standard dressings after cesarean delivery.
   Methods: We conducted a randomized controlled, nonblinded, two-center study of prophylactic negative pressure therapy compared with standard surgical dressings placed at the time of primary closure at cesarean delivery in obese women with body mass indexes (BMI) of 35 or higher (ie, class II and III obesity). Our primary outcome was occurrence of a superficial surgical site infection. We assumed a superficial surgical site infection occurrence rate of 20% and intended to recruit 400 women. However, after low enrollment of 166 women over 24 months, an interim analysis for futility was conducted and the decision was made to halt the study.
   RESULTS: Women were recruited between January 5, 2015, and January 7, 2017, from two sites. The mean BMI on admission was 44.9 (68) for the prophylactic negative wound therapy group and 43.4 (67) for the standard dressing group. There were no differences in the occurrence of observed superficial surgical site infections between women using prophylactic negative pressure wound therapy (12/80 [15%]) compared with women who received the standard dressing (8/81 [10%], P=.35, relative risk 1.52, 95% CI 0.66-3.52). There were no differences in the occurrence of composite wound complications between women using prophylactic negative pressure wound therapy (25/80 [31%]) compared with women who received the standard dressing (24/81 [30%], P=.87).
   CONCLUSION: In this randomized controlled trial that did not achieve full anticipated enrollment, we did not observe a decrease in superficial surgical site infections after cesarean delivery in obese women with the use of prophylactic negative pressure wound therapy.
C1 Geisel Sch Med Dartmouth, Dept Obstet & Gynecol, Lebanon, NH USA.
   Geisel Sch Med Dartmouth, Dept Biomed Data Sci, Lebanon, NH USA.
   Geisel Sch Med Dartmouth, Dartmouth Inst Hlth Policy & Clin Practice, Lebanon, NH USA.
C3 Dartmouth College; Dartmouth College; Dartmouth College
RP Wihbey, KA (通讯作者)，Geisel Sch Med Dartmouth, Dept Obstet & Gynecol, 189 N Main St, Concord, NH 03301 USA.
EM kwihbey@crhc.org
OI Evans, Rebecca/0000-0002-0108-255X
FU KCI Medical (San Antonio, Texas)
FX The devices used in this study were provided by an unrestricted research
   grant from KCI Medical (San Antonio, Texas). KCI Medical had no role in
   the study design, data collection, or data analysis. Final results of
   the study were shared with the company before manuscript submission;
   however, the investigators were not bound to incorporate KCI's comments.
   The authors' decision as to what the manuscript contained was final.
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NR 10
TC 31
Z9 33
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD AUG
PY 2018
VL 132
IS 2
BP 377
EP 384
DI 10.1097/AOG.0000000000002744
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA GR3GB
UT WOS:000442476900021
PM 29995726
DA 2026-07-24
ER
PT J
AU Ge, DM
AF Ge, Dongmei
TI The Safety of Negative-Pressure Wound Therapy on Surgical Wounds: An
   Updated Meta-analysis of 17 Randomized Controlled Trials
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Review
DE bleeding; meta-analysis; negative-pressure wound therapy; NPWT;
   randomized controlled trials; surgical site infection; wound dehiscence;
   wound healing
ID VACUUM-ASSISTED CLOSURE; POLYURETHANE-FOAM; SITE INFECTIONS; LEG ULCERS;
   PILOT RCT; DRESSINGS; MULTICENTER; PREVENTION; GAUZE; RISK
AB OBJECTIVE: To assess whether negative-pressure wound therapy (NPWT) reduced complications such as wound infection, dehiscence, seroma/hematoma, skin necrosis/blistering, and bleeding compared with non-NPWT treatments.
   METHODS: This meta-analysis involved randomized clinical trials of NPWT compared with non-NPWT on surgical wound healing. The main outcome was surgical site infections; secondary outcomes were dehiscence, seroma/hematoma, skin necrosis/blistering, bleeding, and reoperation.
   MAIN RESULTS: Seventeen randomized controlled trials met the inclusion criteria, reporting on 928 NPWT and 930 non-NPWT patients. Compared with non-NPWT, NPWT was not associated with a significant reduction in wound infection (relative risk, 0.96; 95% confidence interval, 0.74-1.24). The reduction in wound dehiscence, seroma/hematoma, skin necrosis/blistering, and bleeding in the NPWT group was significant compared with that in the non-NPWT groups. Significant heterogeneity was observed in seroma/hematoma and skin necrosis/blistering between the NPWT and non-NPWT groups. No publication bias was observed.
   CONCLUSIONS: Compared with non-NPWT, NPWT significantly reduced the rates of dehiscence, seroma/hematoma, skin necrosis\blistering, and bleeding, but not surgical site infections.
C1 [Ge, Dongmei] Shengli Oilfield Cent Hosp, Cent Sterile Supply Dept, Dongying, Shandong, Peoples R China.
RP Ge, DM (通讯作者)，Shengli Oilfield Cent Hosp, Cent Sterile Supply Dept, Dongying, Shandong, Peoples R China.
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NR 41
TC 27
Z9 36
U1 2
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD SEP
PY 2018
VL 31
IS 9
BP 421
EP 428
DI 10.1097/01.ASW.0000542530.71686.5c
PG 8
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA GR7GJ
UT WOS:000442856600007
PM 30134278
DA 2026-07-24
ER
PT J
AU Kao, AM
   Arnold, MR
   Augenstein, VA
   Heniford, BT
AF Kao, Angela M.
   Arnold, Michael R.
   Augenstein, Vedra A.
   Heniford, B. Todd
TI Prevention and Treatment Strategies for Mesh Infection in Abdominal Wall
   Reconstruction
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID INCISIONAL HERNIA REPAIR; PRESSURE WOUND THERAPY; SYNTHETIC MESH;
   COMPLICATIONS; METAANALYSIS; RECURRENCE; SURGERY; PREDICTORS;
   EXPERIENCE; ENTEROTOMY
AB Background: Mesh infection remains the most feared complication after abdominal wall reconstruction, requiring prolonged hospitalizations and often, mesh removal. Understanding of current prevention and treatment strategies is necessary in the management of a common surgical problem.
   Methods: A comprehensive review of the current surgical literature was performed to determine risk factors of mesh infection after abdominal wall reconstruction and best practices in their prevention and surgical management.
   Results: Patient-related risk factors for mesh infections include smoking, obesity, diabetes mellitus. and COPD. Surgical risk factors such as prolonged operative time and prior enterotomy should also be considered. Prevention strategies emphasize reduction of modifiable risk factors, including obesity and diabetes among other comorbidities. Biologic or biosynthetic mesh is recommended in contaminated fields and use of delayed wound closure or vacuum-assisted closure therapy should be considered in high-risk patients. Conservative treatment with antibiotics, percutaneous or surgical drainage, and negative-pressure vacuum-based therapies have demonstrated limited success in mesh salvage. Mesh infection often requires mesh explantation followed by abdominal wall reconstruction. Staged repairs can be performed; however, definitive hernia repair with biologic mesh has shown promising results.
   Conclusions: Management of mesh infections is a complex, yet commonly faced problem. Strategies used in the prevention and surgical treatment of infected mesh should continue to be supported by high-quality evidence from prospective studies.
C1 [Kao, Angela M.; Arnold, Michael R.; Augenstein, Vedra A.; Heniford, B. Todd] Carolinas Med Ctr, Dept Surg, Div Gastrointestinal & Minimally Invas Surg, Charlotte, NC 28203 USA.
C3 Carolinas Medical Center
RP Heniford, BT (通讯作者)，Carolinas Med Ctr, 1025 Morehead Med Dr,Suite 300, Charlotte, NC 28204 USA.
EM todd.heniford@carolinashealthcare.org
FU Allergan; W. L. Gore; KCI; Stryker
FX Dr. Augenstein has received consultation fees from Allergan, W. L. Gore,
   and KCI. Dr. Heniford has received honoraria, speaker's fees, and
   research support from Allergan, W. L. Gore, and Stryker. These
   disclosures do not impact the topics reported herein. All other authors
   declare no disclosures relevant to this article or research.
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   Rios A, 2001, Hernia, V5, P148
   RIVES J, 1985, CHIRURGIE, V111, P215
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   Shubinets V, 2018, ANN PLAS SURG, V80, P145, DOI 10.1097/SAP.0000000000001189
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   ten Broek RPG, 2012, ANN SURG, V256, P280, DOI 10.1097/SLA.0b013e31826029a8
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NR 56
TC 104
Z9 120
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2018
VL 142
IS 3
SU S
BP 149S
EP 155S
DI 10.1097/PRS.0000000000004871
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GR7GV
UT WOS:000442857900026
PM 30138283
DA 2026-07-24
ER
PT J
AU Arai, M
   Kim, S
   Ishii, H
   Hagiwara, J
   Kushimoto, S
   Yokota, H
AF Arai, Masatoku
   Kim, Shiei
   Ishii, Hiromoto
   Hagiwara, Jun
   Kushimoto, Shigeki
   Yokota, Hiroyuki
TI The long-term outcomes of early abdominal wall reconstruction by
   bilateral anterior rectus abdominis sheath turnover flap method in
   critically ill patients requiring open abdomen
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Open abdomen; Negative pressure wound therapy; Abdominal wall
   reconstruction; Abdominal compartment syndrome
ID FASCIAL CLOSURE; TRACTION; REPAIR
AB Background: In a previous study, we reported the usefulness of early abdominal wall reconstruction using bilateral anterior rectus abdominis sheath turnover flap method (turnover flap method) in open abdomen (OA) patients in whom early primary fascial closure was difficult to achieve. However, the long-term outcomes have not been elucidated. In the present study, we aimed to evaluate the procedure, particularly in terms of ventral hernia, pain, and daily activities.
   Methods: Between 2001 and 2013, 15 consecutive patients requiring OA after emergency laparotomy and in whom turnover flap method was applied were retrospectively identified. The long-term outcomes were evaluated based on medical records, physical examinations, CT imaging, and a ventral hernia pain questionnaire (VHPQ).
   Results: The turnover flap method was applied in 2 trauma and 13 non-trauma patients.
   In most of cases, primary fascial closure could not be achieved due to massive visceral edema. The turnover flap method was performed for abdominal wall reconstruction at the end of OA. The median duration of OA was 6 (range 1-42) days. One of the 15 patients died of multiple organ failure during initial hospitalization after the performance of the turnover flap method. Fourteen patients survived, and although wound infection was observed in 3 patients, none showed enteric fistula, abdominal abscess, graft infection, or ventral hernia during hospitalization. However, it was found that 1 patient developed ventral hernia during follow-up at an outpatient visit. Nine of 14 patients were alive and able to be evaluated with a VHPQ (follow-up period: median 10 years; range 3-15 years). Seven out of nine patients were satisfied with this procedure, and none complained of pain or were limited in their daily activities.
   Conclusions: Based on the results of this study, early abdominal reconstruction using the turnover flap method can be considered to be safe and effective as an alternative technique for OA patients in whom primary fascial closure is considered difficult to achieve.
C1 [Arai, Masatoku; Kim, Shiei; Ishii, Hiromoto; Hagiwara, Jun; Yokota, Hiroyuki] Nippon Med Sch, Dept Emergency & Crit Care Med, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan.
   [Kushimoto, Shigeki] Tohoku Univ, Div Emergency & Crit Care Med, Grad Sch Med, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan.
C3 Nippon Medical School; Tohoku University
RP Arai, M (通讯作者)，Nippon Med Sch, Dept Emergency & Crit Care Med, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan.
EM amasatoku@nms.ac.jp
RI Kushimoto, Shigeki/AET-6785-2022
CR Acosta S, 2016, EUR J VASC ENDOVASC, V51, P371, DOI 10.1016/j.ejvs.2015.10.014
   Arai M, 2018, CHIRURGIA BUCUR
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   den Hartog D, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006438.pub2
   Kirkpatrick AW, 2013, INTENS CARE MED, V39, P1190, DOI 10.1007/s00134-013-2906-z
   Kushimoto S, 2007, WORLD J SURG, V31, P2, DOI 10.1007/s00268-006-0282-3
   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
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NR 13
TC 8
Z9 11
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD SEP 4
PY 2018
VL 13
AR 39
DI 10.1186/s13017-018-0200-7
PG 6
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA GS4VP
UT WOS:000443651600001
PM 30202428
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Balci, MK
   Ciger, E
   Arslanoglu, S
   Islek, A
AF Balci, Mustafa Koray
   Ciger, Ejder
   Arslanoglu, Secil
   Islek, Akif
TI Necrotizing fasciitis of the head and neck: our experience with
   vacuum-assisted closure therapy
SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
LA English
DT Article
DE Necrotising fasciitis; Head and neck necrotising fasciitis;
   Vacuum-assisted closure
ID SOFT-TISSUE INFECTIONS; COMPUTED-TOMOGRAPHY; MANAGEMENT; DIAGNOSIS
AB ObjectivesTo present the outcomes of our case series of head and neck necrotizing fasciitis (HNNF) in which vacuum-assisted closure (VAC) is used in most of the cases in the treatment.MethodsCase series in a tertiary referral center.ResultsEleven patients were treated for HNNF between January 2008 and January 2017. Patients were two females and nine males, the mean age was 57.1. Oral cavity and tracheotomy/tracheostomy sites were the main aetiological foci of the infection. Three patients were treated with aggressive debridements and conventional dressing, whereas eight patients were treated with incision and exploration followed by limited skin excisions and VAC dressing. The mean number of surgical debridements was 2.3. The mean length of hospital stay was 41.8days. Complications were observed in all patients except one. The mortality rate of HNNF in our series was 18%. The cause of death was severe sepsis and multi-organ failure in one case and mediastinitis followed by respiratory distress syndrome in the other case.ConclusionHNNF is still a mortal disease and surgical debridements are crucial. The current study is the only case series in the literature in which VAC treatment was used in consecutive cases of HNNF. VAC treatment can play a major role in the post-operative care of HNNF patients. It reduces the amount of excised skin during debridements and stimulates wound healing. VAC treatment may be included in the treatment protocol of HNNF alongside surgical debridements and medical therapy.
C1 [Balci, Mustafa Koray; Ciger, Ejder; Arslanoglu, Secil; Islek, Akif] Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Otorhinolaryngol, Basin Sitesi Mh, TR-35170 Izmir, Turkey.
C3 Izmir Katip Celebi University; Izmir Ataturk Training & Research
   Hospital
RP Balci, MK (通讯作者)，Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Otorhinolaryngol, Basin Sitesi Mh, TR-35170 Izmir, Turkey.
EM m.koray.balci@gmail.com
RI ciğer, ejder/AAN-3136-2021; İŞLEK, AKİF/AAH-2799-2020; Balcı, Mustafa
   Koray/AAL-4967-2021
OI İŞLEK, AKİF/0000-0001-7058-3457; Balcı, Mustafa
   Koray/0000-0002-7008-1964
CR [Anonymous], ANN SURG
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NR 22
TC 17
Z9 22
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0937-4477
EI 1434-4726
J9 EUR ARCH OTO-RHINO-L
JI Eur. Arch. Oto-Rhino-Laryn.
PD OCT
PY 2018
VL 275
IS 10
BP 2555
EP 2562
DI 10.1007/s00405-018-5096-z
PG 8
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA GS5HV
UT WOS:000443690000018
PM 30120554
DA 2026-07-24
ER
PT J
AU Davis, J
   Caruso, DM
   Foster, KN
   Matthews, MR
AF Davis, John
   Caruso, Daniel M.
   Foster, Kevin N.
   Matthews, Marc R.
TI A Novel Approach To Sealing The Denuded Dermis of the Abdominal Wall
   With A Negative Pressure Wound Device After A Decompressive Laparotomy
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID OPEN ABDOMEN; MANAGEMENT; THERAPY
AB The open abdomen is a well-known technique that is applied in a wide variety of clinical situations, including treatment of abdominal compartment syndrome, damage control laparotomy, and severe intraabdominal sepsis. Disease states such as Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis or extensive deep partial and/or full-thickness torso burns involving the abdomen often result in a complete epidermal and partial dermal loss. When ABThera Open Abdomen Negative Pressure Wound Therapy is attempted in these patients, the exposed subcutaneous tissue rarely allows for an adequate seal between the adhesive barrier and the denuded skin. This is because successful placement of negative pressure wound therapy device necessitates having a dry epidermal surface allowing the adhesive tape to actually adhere. The ABThera Open Abdomen Negative Pressure Wound Therapy visceral protective layer was placed over the exposed bowel, followed by the blue perforated foam interface and then the adhesive barrier drape. Over the top of the "less-than-air-tight" adhesive barrier drape was placed a standard isolation transport bowel bag, which was stapled to the dermis, but outside of the previously placed adhesive barrier drape's diameter to "bolster" the adhesive barrier drape, only allowing the suction tube to extend inferiorly. This ABThera Open Abdomen Negative Pressure Wound Therapy ABNPWT held suction, even during multiple adjacent dressing changes, despite the exposed dermis. This case report reveals a unique approach that solves the issue of inadequate seal due to extensive burns to the torso and has significant benefit in burn and wound care practices.
C1 [Davis, John; Caruso, Daniel M.; Matthews, Marc R.] Maricopa Integrated Hlth Syst, Dept Surg, Phoenix, AZ USA.
   [Foster, Kevin N.] Maricopa Integrated Hlth Syst, Arizona Burn Ctr, Dept Surg, 2601 East Roosevelt St, Phoenix, AZ 85008 USA.
C3 Maricopa County General Hospital; Maricopa Integrated Health System;
   Maricopa County General Hospital; Maricopa Integrated Health System
RP Matthews, MR (通讯作者)，Maricopa Integrated Hlth Syst, Arizona Burn Ctr, Dept Surg, 2601 East Roosevelt St, Phoenix, AZ 85008 USA.
EM marc_matthews@dmgaz.org
CR Cheatham ML, 2013, WORLD J SURG, V37, P2018, DOI 10.1007/s00268-013-2080-z
   Chong Si Jack, 2010, Burns, V36, pe127, DOI 10.1016/j.burns.2010.05.007
   Hardin MO, 2012, J BURN CARE RES, V33, P491, DOI 10.1097/BCR.0b013e3182479b00
   Low OW, 2013, BURNS, V39, P1420, DOI 10.1016/j.burns.2013.03.010
   Navsaria P, 2013, WORLD J EMERG SURG, V8, DOI 10.1186/1749-7922-8-4
   Regner JL, 2012, WORLD J SURG, V36, P497, DOI 10.1007/s00268-011-1203-7
   Roberts DJ, 2012, J TRAUMA ACUTE CARE, V73, P629, DOI 10.1097/TA.0b013e31825c130e
NR 7
TC 3
Z9 3
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD SEP-OCT
PY 2018
VL 39
IS 5
BP 838
EP 842
DI 10.1097/BCR.0000000000000615
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA GS6KY
UT WOS:000443806000031
PM 28661985
DA 2026-07-24
ER
PT J
AU Settembre, N
   D'oria, M
   Saba, C
   Bouziane, Z
   Malikov, S
AF Settembre, Nicla
   D'oria, Mario
   Saba, Charbel
   Bouziane, Zakariyae
   Malikov, Serguei
TI Negative Pressure Wound Therapy to Promote Fixation and Remodeling of
   Omental Flap in Patients with Revascularized Limbs: A Case Series
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID FREE TISSUE TRANSFER; COMBINED ARTERIAL RECONSTRUCTION; BYPASS FLAP;
   MANAGEMENT; SALVAGE; FLOW
AB We present our experience with 5 patients with chronic limb threatening ischemia (CLTI) treated with distal revascularization and omental flap coverage. We decided to investigate the efficacy and safety of negative-pressure wound therapy (NPWT) in promoting the fixation and remodeling of the omental flap as there is some evidence in the literature about the optimization of results for skin graft and dermal substitutes. Surgical revascularization was always the first procedure attempted; wound coverage was realized 3-5 days after the primary procedure (omental free-flap in 3 patients and omental flow-through flap in 2 patients). NPWT with small foam at -75 mm Hg was applied on the second postoperative day after flap coverage. Effective remodeling of the flap was defined as the flap overcoming the wound edge no more than 10 mm. Limb salvage rate was 100%; in all the patients, and we observed satisfactory fixation and remodeling of the omental flap after 10-20 days of NPWT, secondary skin grafting within 34 weeks after revascularization, and adequate and complete mobilization within 6 months after hospital discharge. We did not report any relapsing infection nor any recurrent wound up to 2 years of follow-up. Distal revascularization combined with omental free-flap or flow-through flap is highly effective for limb salvage in CLTI patients with complex wounds. NPWT may be an useful adjunct to promote fixation and remodeling of the omental flap before secondary skin grafting. It may reduce secondary issues related to omental flap coverage allowing rapid and satisfactory mobilization of patients.
C1 [Settembre, Nicla; D'oria, Mario; Saba, Charbel; Bouziane, Zakariyae; Malikov, Serguei] Univ Lorraine, Nancy Univ Hosp, Dept Vasc Surg, Nancy, France.
   [Settembre, Nicla; Malikov, Serguei] Univ Lorraine, INSERM 1116, Nancy, France.
C3 CHU de Nancy; Universite de Lorraine; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite de Lorraine
RP Settembre, N (通讯作者)，Univ Lorraine, Nancy Univ Hosp, Dept Vasc Surg, 1 Rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
EM nicla.settembre@yahoo.com
RI D'Oria, Mario/AAF-5578-2020
OI D'Oria, Mario/0000-0002-7156-7827; Settembre, Nicla/0000-0003-3107-2771
CR Aboyans V, 2017, EUR J VASC ENDOVASC, V2017, P25
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   Borgquist O, 2010, PLAST RECONSTR SURG, V125, P502, DOI 10.1097/PRS.0b013e3181c82e1f
   Bovill E, 2008, INT WOUND J, V5, P511, DOI 10.1111/j.1742-481X.2008.00437.x
   De Caridi G, 2016, INT WOUND J, V13, P336, DOI 10.1111/iwj.12301
   Gabriel A, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00628.x
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   Malikov S, 2008, J VASC SURG, V48, P159, DOI 10.1016/j.jvs.2008.02.023
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   Maloney CT Jr, 2003, PLAST RECONSTR SURG, V111, P1899, DOI 10.1097/01.PRS.0000056874.31920.7D
   McCarthy WJ, 1999, J VASC SURG, V29, P814, DOI 10.1016/S0741-5214(99)70208-9
   Noble-Bell G, 2008, INT WOUND J, V5, P233, DOI 10.1111/j.1742-481X.2008.00430.x
   Norgren L, 2007, EUR J VASC ENDOVASC, V33, pS5, DOI 10.1016/j.ejvs.2006.09.024
   O'Connor EJF, 2011, EUR J VASC ENDOVASC, V41, P391, DOI 10.1016/j.ejvs.2010.11.013
   Schuler J, 1999, J VASC SURG, V29, P818
   Settembre N, 2018, SURG RADIOL ANAT, V40, P415, DOI 10.1007/s00276-017-1951-7
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NR 22
TC 3
Z9 5
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD OCT
PY 2018
VL 52
AR 313.e5
DI 10.1016/j.avsg.2018.03.006
PG 4
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA GS8RN
UT WOS:000443980600044
PM 29777840
DA 2026-07-24
ER
PT J
AU Wesslén, C
   Wahlgren, CM
AF Wesslen, Charlotte
   Wahlgren, Carl-Magnus
TI Contemporary Management and Outcome After Lower Extremity Fasciotomy in
   Non-Trauma-Related Vascular Surgery
SO VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE fasciotomy; compartment syndrome; lower extremity ischemia
ID ACUTE COMPARTMENT SYNDROME; ACUTE LIMB ISCHEMIA; AMPUTATION; DIAGNOSIS
AB Introduction: Acute compartment syndrome (ACS) is a challenging and recognized complication to vascular surgery revascularization. The aim of this study was to investigate the current epidemiology, management, and early outcomes of fasciotomy in vascular surgery. Methods: Retrospective cohort study of all patients undergoing lower extremity fasciotomy at a single university center between January 2008 and December 2014. Patient demographics, operative techniques, and outcomes were analyzed. Results: The cohort (n = 113 limbs; 107 patients; 48% women; mean age was 74 (12) years [range, 50-97 years]) included 81 (72%) limbs undergoing revascularization for acute limb ischemia, 7 (6.2%) limbs related to acute aortic disease, and 23 (20%) limbs undergoing elective vascular surgery. Five patients underwent bilateral lower extremity fasciotomy. In all, 64 (57%) limbs had signs of ACS and underwent a therapeutic fasciotomy, while 49 (43%) fasciotomies were prophylactic. There were 20 (18%) fasciotomies performed after endovascular interventions. A 4-compartment fasciotomy was performed in 82% (n = 93) of limbs with a double incision technique. Split thickness skin graft was required in 11% (12/112) and vacuum-assisted closure treatment in 11% (12/111). The mean length of stay in hospital was 11 (9) days. Most common complication was lower extremity nerve deficit 32% (33/104) followed by wound infection 30% (32/108). At 30-day follow-up, amputation rate was 13% (14/107 limbs) and mortality 23% (25/107 patients). In the multivariate logistic regression analysis, prophylactic fasciotomy was associated with amputation (odds ratio: 28.9; 95% confidence interval: 1.96-425; P = .014). Conclusion: Acute compartment syndrome is primarily related to acute ischemic conditions but occurs after both aortic or elective vascular procedures and endovascular treatments. There are significant complications related to lower extremity fasciotomy in vascular surgery.
C1 [Wesslen, Charlotte; Wahlgren, Carl-Magnus] Karolinska Inst, Dept Mol Med & Surg, Solna, Sweden.
   [Wesslen, Charlotte; Wahlgren, Carl-Magnus] Karolinska Univ Hosp, Dept Vasc Surg, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital
RP Wahlgren, CM (通讯作者)，Karolinska Inst, Dept Vasc Surg A2 01, S-17176 Stockholm, Sweden.; Wahlgren, CM (通讯作者)，Karolinska Univ Hosp, S-17176 Stockholm, Sweden.
EM carl.wahlgren@sll.se
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NR 18
TC 21
Z9 26
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1538-5744
EI 1938-9116
J9 VASC ENDOVASC SURG
JI Vasc. Endovasc. Surg.
PD OCT
PY 2018
VL 52
IS 7
BP 493
EP 497
DI 10.1177/1538574418773503
PG 5
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA GT3WU
UT WOS:000444435600001
PM 29716475
DA 2026-07-24
ER
PT J
AU Liu, Y
   Tang, NN
   Cao, K
   Wang, SH
   Tang, SJ
   Su, HH
   Zhou, JD
AF Liu, Yu
   Tang, Ningning
   Cao, Ke
   Wang, Shaohua
   Tang, Sijie
   Su, Honghui
   Zhou, Jianda
TI Negative-Pressure Wound Therapy Promotes Wound Healing by Enhancing
   Angiogenesis Through Suppression of NLRX1 via miR-195 Upregulation
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE negative-pressure wound therapy; microRNA-195; NLRX1; angiogenesis
ID NF-KAPPA-B; TUMOR ANGIOGENESIS; GROWTH-FACTOR; EXPRESSION; INHIBITION;
   VEGF; CARCINOMA; PATHWAYS; CANCER
AB Negative-pressure wound therapy (NPWT) is one of the most advanced therapeutic methods in the treatment of various hard-to-heal acute and refractory chronic wounds. Recent emerging evidence points to a role of the microRNA-mediated regulation of angiogenesis in ischemic tissues, and a series of microRNAs associated with angiogenesis have been successively identified. In this study, we found that miR-195 expression was significantly upregulated and the microvessel density (MVD) was increased in granulation tissue collected 7 days after NPWT compared with those in the pre-NPWT tissue. Moreover, the expression of NLRX1, the potential target gene of miR-195, was down-regulated in post-NPWT compared with that in pre-NPWT tissue. Significant negative correlations were detected between miR-195 and NLRX1 expression levels (r = -.856, P < .001) and between NLRX1 expression and MVD (r = -.618, P < .05), whereas miR-195 expression was positively correlated with MVD in the granulation tissue (r = .630, P < .05). In summary, NPWT may suppress NLRX1 expression through the upregulation of miR-195 expression, thus efficaciously promoting angiogenesis in the granulation tissue to enhance wound healing.
C1 [Liu, Yu; Tang, Ningning; Cao, Ke; Wang, Shaohua; Su, Honghui; Zhou, Jianda] Cent S Univ, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.
   [Liu, Yu] Inner Mongolia Med Univ, Hohhot, Inner Mongolia, Peoples R China.
   [Tang, Ningning] Xiangya Changde Hosp, Changde, Hunan, Peoples R China.
   [Tang, Sijie] Shantou Univ, Coll Med, Affiliated Hosp 2, Shantou, Guangdong, Peoples R China.
C3 Central South University; Inner Mongolia Medical University; Shantou
   University
RP Zhou, JD (通讯作者)，Cent S Univ, Xiangya Hosp 3, Dept Plast Surg, Changsha, Hunan, Peoples R China.
EM zhoujianda@csu.edu.cn
RI Tang, Ni/Z-5133-2019; Liu, Yu/KRP-3189-2024
OI Liu, Yu/0000-0001-5996-0469
FU National Science Foundation of Hunan Province [2015JJ4053]; Hunan Health
   and Family Planning Commission Research Project [B2016-126, 2015-40];
   Science and Technology Million Project of Inner Mongolia Medical
   University [YKD2017KJBW016]; Inner Mongolia Autonomous Region Natural
   Science Fund [2018BS08009]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: (1)
   National Science Foundation of Hunan Province (2015JJ4053); (2) Hunan
   Health and Family Planning Commission Research Project (B2016-126,
   2015-40); (3) Science and Technology Million Project of Inner Mongolia
   Medical University (YKD2017KJBW016); and (4) Inner Mongolia Autonomous
   Region Natural Science Fund (2018BS08009).
CR Allen IC, 2011, IMMUNITY, V34, P854, DOI 10.1016/j.immuni.2011.03.026
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NR 24
TC 16
Z9 21
U1 0
U2 13
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2018
VL 17
IS 3
BP 144
EP 150
DI 10.1177/1534734618794856
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GT6BD
UT WOS:000444594400003
PM 30141361
DA 2026-07-24
ER
PT J
AU Pertea, M
   Velenciuc, N
   Poroch, V
   Ciobanu, P
   Boanca, M
   Grosu, OM
   Lunca, S
AF Pertea, Mihaela
   Velenciuc, Natalia
   Poroch, Vladimir
   Ciobanu, Petru
   Boanca, Mihaela
   Grosu, Oxana Madalina
   Lunca, Sorinel
TI Efficacy of Negative Pressure Therapy (NPWT) in the Management of Wounds
   of Different Etiologies
SO REVISTA DE CHIMIE
LA English
DT Article
DE negative pressure wound therapy; Vacuum Assisted Closure; subatmospheric
   pressure; oncological abdominal surgery; perilesional erythema;
   granulation tissue
ID VACUUM-ASSISTED CLOSURE; PROLIFERATION; GRANULATION; SAFETY
AB The objective was to assess the role of negative pressure wound therapy (NPWT) in the management of wounds of various etiologies, infected or not, acute or chronic. The study was conducted in a group of 37 patients (24 men and 13 women) aged 26 to 86 years with acute or chronic wounds, posttraumatic or due to chronic diseases located on the lower limbs or following oncological abdominal surgery. In all cases a Vacuum Assisted Closure (VAC) system was continuously applied using a subatmospheric pressure ranging from 90 to 120 mmHg. Beside sex, age and etiology of soft tissue defect the following parameters were studied: surgical treatment performed prior to NPWT application, frequency of dressing changes, duration of NPWT, level of subatmospheric pressure used in each case, number of hospital days, complications arising from NPWT use. The outcome was favorable in all cases without such complications as infection or bleeding, a perilesional erythema (contact dermatitis caused by the used adhesive tape) being noted in only 13.51% of cases. The average duration of NPWT was 8.1 days. The frequency of dressing changes was in most cases of 3 days (89.18%) with a group mean of 3.05 days, and the average applied negative pressure was -110.83 mmHg, range -90mmHg to -120 mm Hg. No complications requiring the interruption of NPWT use were recorded. NPWT, by stimulating wound constriction and granulation tissue formation is an option in the management of acute or chronic wounds of various etiologies, whether infected or not, resulting in a decrease in the number of surgeries and their complexity, length of hospital stay and, last but not least, reduced patient suffering.
C1 [Pertea, Mihaela; Velenciuc, Natalia; Poroch, Vladimir; Boanca, Mihaela; Grosu, Oxana Madalina; Lunca, Sorinel] Grigore T Popa Univ Med & Pharm Iasi, 16 Univ Str, Iasi 700115, Romania.
   [Pertea, Mihaela; Ciobanu, Petru; Grosu, Oxana Madalina] Sf Spiridon Emergency Hosp, Clin Plast & Reconstruct Microsurg, 1 Independentei Sq, Iasi 700111, Romania.
   [Velenciuc, Natalia; Poroch, Vladimir; Lunca, Sorinel] Reg Inst Oncol, 2-4 G Ral Berthelot Str, Iasi 700483, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Regional Institute of Oncology IASI
RP Pertea, M; Poroch, V (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, 16 Univ Str, Iasi 700115, Romania.; Pertea, M (通讯作者)，Sf Spiridon Emergency Hosp, Clin Plast & Reconstruct Microsurg, 1 Independentei Sq, Iasi 700111, Romania.; Poroch, V (通讯作者)，Reg Inst Oncol, 2-4 G Ral Berthelot Str, Iasi 700483, Romania.
EM pertea_mihaela@yahoo.com; vlader2000@yahoo.com
RI Lunca, Sorinel/KLY-5481-2024; Poroch, Vladimir/K-2611-2013; Grosu,
   Oxana/GWQ-7540-2022; Pertea, Mihaela/AGZ-3559-2022
OI Lunca, Sorinel/0000-0002-9749-0610; Poroch,
   Vladimir/0000-0002-2503-5395; 
CR Agheorghiesei TD, 2015, RETHINKING SOCIAL ACTION. CORE VALUES, P33
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NR 30
TC 14
Z9 14
U1 0
U2 11
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD AUG
PY 2018
VL 69
IS 8
BP 1980
EP 1986
PG 7
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA GT6ED
UT WOS:000444602300012
DA 2026-07-24
ER
PT J
AU Gatti, G
   Benussi, B
   Brunetti, D
   Ceschia, A
   Porcari, A
   Biondi, F
   Castaldi, G
   Luzzati, R
   Sinagra, G
   Pappalardo, A
AF Gatti, Giuseppe
   Benussi, Bernardo
   Brunetti, Davide
   Ceschia, Alessandro
   Porcari, Aldostefano
   Biondi, Federico
   Castaldi, Gianluca
   Luzzati, Roberto
   Sinagra, Gianfranco
   Pappalardo, Aniello
TI The fate of patients having deep sternal infection after bilateral
   internal thoracic artery grafting in the negative pressure wound therapy
   era
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Arterial grafts; Coronary artery bypass grafting; Mortality/survival;
   Risk factors; Sternal wound infection
ID SURGICAL-SITE INFECTIONS; LONG-TERM SURVIVAL; BYPASS GRAFT;
   RISK-FACTORS; DIABETIC-PATIENTS; ROUTINE USE; CORONARY; SURGERY;
   REVASCULARIZATION; MEDIASTINITIS
AB Background: Late survival of patients having deep sternal wound infection (DSWI) after bilateral internal thoracic artery (BITA) grafting is largely unexplored.
   Methods: Outcomes of 3391 consecutive BITA patients were reviewed retrospectively. Patients with DSWI after surgery (n = 142, 4.2%) were compared with those having no sternal complications (n = 3177). Predictors of DSWI and of mortality during the follow-up period were found with negative-binomial and Cox proportional-hazards regression, respectively. One-to-one propensity score-matched analysis, which considered simultaneously baseline patient characteristics, operative data, and postoperative complications was performed. The resulting matched pairs were compared for non-parametric estimates of late survival. The same comparison was performed in matched pairs having no major complications (except DSWI) early after surgery.
   Results: In-hospital mortality was higher in DSWI cohort than in patients having no sternal complications (5.6% vs. 1.8%, p = 0.0035). Almost all of postoperative complications were more frequent in DSWI patients. Female sex, obesity, chronic lung disease, renal impairment, extracardiac arteriopathy, congestive heart failure, and urgent/emergency priority were predictors of DSWI common to two DSWI risk models that were developed. DSWI was independent predictor of reduced late survival (multiple covariates-adjusted hazard ratio [HR], 1.91, p < 0.0001). The propensity matching resulted in 135 pairs with same in-hospital mortality (5.2%). Estimates of freedom from all-cause death were lower in DSWI cohort (HR, 1.92, p < 0.0001), even when only pairs (n = 59) having nomajor postoperative complications (except DSWI) were considered (HR, 1.84, p = 0.026).
   Conclusions: DSWI after BITA use seems to reduce late survival even after adjusting for baseline patient characteristics and concomitant postoperative complications. (c) 2018 Elsevier B.V. All rights reserved.
C1 [Gatti, Giuseppe; Benussi, Bernardo; Ceschia, Alessandro; Porcari, Aldostefano; Biondi, Federico; Castaldi, Gianluca; Sinagra, Gianfranco; Pappalardo, Aniello] Univ Hosp Trieste, Cardiothorac & Vasc Dept, Trieste, Italy.
   [Brunetti, Davide] Univ Hosp Trieste, Dept Med Sci, Trieste, Italy.
   [Luzzati, Roberto] Univ Hosp Trieste, Div Infect Dis, Trieste, Italy.
C3 University of Trieste; University Trieste Hospital; University of
   Trieste; University Trieste Hospital; University of Trieste; University
   Trieste Hospital
RP Gatti, G (通讯作者)，Osped Cattinara, Div Cardiac Surg, Via P Valdoni 7, I-34148 Trieste, Italy.
EM giuseppe.gatti@asuits.sanita.fvg.it
RI Porcari, Aldostefano/AAU-8846-2021; Sinagra, Gianfranco/AAE-3943-2020;
   /ABE-8809-2020; Gatti, Giuseppe/A-3849-2017; Luzzati,
   Roberto/AAU-6939-2021
OI Porcari, Aldostefano/0000-0003-3307-0825; Gatti,
   Giuseppe/0000-0002-9996-6133; Luzzati, Roberto/0000-0001-5546-0715
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NR 50
TC 15
Z9 15
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD OCT 15
PY 2018
VL 269
BP 67
EP 74
DI 10.1016/j.ijcard.2018.07.090
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GT6FP
UT WOS:000444606500014
PM 30049494
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Thorup, CB
   Hougaard, M
   Blindum, PF
   Sorensen, EE
AF Thorup, Charlotte B.
   Hougaard, Mette
   Blindum, Pernille F.
   Sorensen, Erik E.
TI Hospitalised patients' experiences during Negative Pressure Wound
   Therapy due to surgical site infection after vascular and cardiac
   surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure wound therapy; NPWT; patient experience; qualitative
   interview; surgical site infections
ID IMPACT; CARE; NPWT; PARTICIPATION; ALGINATE; CLOSURE; GROIN; PAIN
AB Surgical site infections that develop after vascular and cardiac surgery are often treated with Negative Pressure Wound Therapy (NPWT). Due to the severity of the infection and risk of bleeding, this NPWT often requires hospitalisation. Fourteen patients were selected for qualitative interviews to investigate their experiences and the meaning of patient participation during hospitalisation with NPWT. Results show that hospitalisation induces tension between an intrusion of privacy and being part of a community. Patients do not feel ill nor are considered ill. They feel minimised, lack participation and miss continuity, yet they still accept their circumstances by adjusting to hospital routines and treatment. The hospital's organisational framework compromises patient participation, yet patients still participate in supporting their own wound healing. They worry, are bored, lack a clear time horizon, and appear to be in an apathetic mood despite having significant time on their hands. In conclusion, the tension between a patient's privacy and sense of community, as well as involuntary participation in other patients' lives, compromises dignity and increases stress. Wound healing appears to be prolonged due to fasting, inactivity and stress. Self-reliant patients are at risk of being minimised and lack adequate emotional care, and the hospital's organisational framework hampers patient feelings of involvement and participation.
C1 [Thorup, Charlotte B.] Aalborg Univ Hosp, Dept Cardiothorac Surg, Aalborg, Denmark.
   [Thorup, Charlotte B.] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark.
   [Thorup, Charlotte B.; Sorensen, Erik E.] Aalborg Univ Hosp, Clincal Nursing Res Unit, Aalborg, Denmark.
   [Hougaard, Mette] Aalborg Univ Hosp, Dept Heart & Lung Surg, Aalborg, Denmark.
   [Blindum, Pernille F.] Aalborg Univ Hosp, Dept Vasc Surg, Aalborg, Denmark.
   [Sorensen, Erik E.] Aalborg Univ, Dept Clin Med, Aalborg, Denmark.
C3 Aalborg University; Aalborg University Hospital; Aalborg University;
   Aalborg University Hospital; Aalborg University; Aalborg University
   Hospital; Aalborg University; Aalborg University Hospital; Aalborg
   University; Aalborg University Hospital; Aalborg University
RP Thorup, CB (通讯作者)，Aalborg Univ Hosp, Sondre Skovvej 5,3 Etage,Off 313, DK-9000 Aalborg, Denmark.
EM cbt@rn.dk
OI Thorup, Charlotte Brun/0000-0002-7519-2639
FU Department of cardiothoracic surgery at Aalborg University Hospital;
   Department of Valve Surgery at Aalborg University Hospital
FX The authors thank the Department of cardiothoracic surgery and
   Department of Valve Surgery at Aalborg University Hospital for
   supporting this research. The authors declare that they have no
   competing interests.
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NR 36
TC 12
Z9 13
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2018
VL 15
IS 5
BP 707
EP 716
DI 10.1111/iwj.12913
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Surgery
GA GU0OU
UT WOS:000444951400004
PM 29927043
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Wirth, U
   Renz, BW
   Andrade, D
   Schiergens, TS
   Arbogast, H
   Andrassy, J
   Werner, J
AF Wirth, Ulrich
   Renz, Bernhard W.
   Andrade, Dorian
   Schiergens, Tobias S.
   Arbogast, Helmut
   Andrassy, Joachim
   Werner, Jens
TI Successful treatment of enteroatmospheric fistulas in combination with
   negative pressure wound therapy: Experience on 3 cases and literature
   review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE enteroatmospheric fistula; fistula adapter; fistula isolation; negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; CLINICAL-OUTCOMES; MANAGEMENT;
   DEVICE; SYSTEM
AB Enteroatmospheric fistulas (EAF) are rare but challenging and morbid complications of abdominal surgery and require time- as well as resource-consuming management. Furthermore, they severely affect patients' quality of life. Several treatment modalities for EAF management are described in the literature. We describe 3 consecutive cases of EAF treatment by employing negative pressure wound therapy (NPWT) along with either a special silicone fistula adapter or a Silo-Vac-like system in another case to isolate the fistula from the remaining abdominal wound. Spontaneous fistula closure was achieved in 2 of the 3 cases, and surgical resection of the small bowel segment harbouring EAF opening was possible in a third case after wound conditioning. The rate of fistula closure was 100% (n=3/3). Compartmentalisation of the contaminated area using NPWT accelerated healing of the open abdominal wound remarkably. In summary, we present a useful tool for the challenging management of EAF and review the literature on different treatment options of EAF available today.
C1 [Wirth, Ulrich; Renz, Bernhard W.; Andrade, Dorian; Schiergens, Tobias S.; Arbogast, Helmut; Andrassy, Joachim; Werner, Jens] Hosp Univ Munich, Dept Gen Visceral & Transplantat Surg, D-81377 Munich, Germany.
C3 University of Munich
RP Wirth, U (通讯作者)，Hosp Univ Munich, Dept Gen Visceral & Transplantat Surg, D-81377 Munich, Germany.
EM ulrich.wirth@med.uni-muenchen.de
RI Anassy, Joachim/AEW-2583-2022; Renz, Bernhard W/AGE-4868-2022
OI Anassy, Joachim/0000-0001-8303-3913; Renz, Bernhard
   W/0000-0001-9574-8051
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NR 33
TC 12
Z9 16
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2018
VL 15
IS 5
BP 722
EP 730
DI 10.1111/iwj.12916
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GU0OU
UT WOS:000444951400006
PM 29600578
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Cahill, C
   Fowler, A
   Williams, LJ
AF Cahill, Caitlin
   Fowler, Amanda
   Williams, Lara J.
TI The application of incisional negative pressure wound therapy for
   perineal wounds: A systematic review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE abdominoperineal; colorectal; incisional negative pressure wound
   therapy; VAC
ID EXTRALEVATOR ABDOMINOPERINEAL EXCISION; SURGICAL SITE INFECTIONS;
   PRIMARY CLOSURE; RECTAL-CANCER; MANAGEMENT-SYSTEM; RISK-FACTORS;
   RESECTION; COMPLICATIONS; RECONSTRUCTION; SURGERY
AB Impaired perineal wound healing is a major source of morbidity after abdominoperineal resection. Incisional negative pressure wound therapy can improve healing, prevent infections, and decrease the frequency of dehiscence. Our objective was to summarise existing evidence on the use of incisional negative pressure wound therapy on perineal wounds after abdominoperineal resection and to determine the effect on perineal wound complications. Electronic databases were searched in January 2017. Studies describing the use of incisional negative pressure wound therapy on primarily closed perineal wounds after abdominoperineal resection were included. Of the 278 identified articles, 5 were retrieved for inclusion in the systematic review (n=169 patients). A significant decrease in perineal wound complications when using incisional negative pressure wound therapy was demonstrated, with surgical site infection rates as low as 9% (vs 41% in control groups). The major limitation of this systematic review was a small number of retrieved studies with small patient populations, high heterogeneity, and methodological issues. This review suggests that incisional negative pressure wound therapy decreases perineal wound complications after abdominoperineal resection. Further prospective trials with larger patient populations would be needed to confirm this association and delineate which patients might benefit most from the intervention.
C1 [Cahill, Caitlin; Fowler, Amanda; Williams, Lara J.] Ottawa Hosp, Div Gen Surg, Sect Colorectal & Minimally Invas Surg, Ottawa, ON, Canada.
C3 University of Ottawa; Ottawa Hospital Research Institute
RP Williams, LJ (通讯作者)，Civ Parkdale Clin, 737 Parkdale Ave,3rd Floor, Ottawa, ON K1Y 1J8, Canada.
EM larwilliams@toh.ca
OI Cahill, Caitlin/0000-0003-2705-6074
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NR 43
TC 20
Z9 30
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2018
VL 15
IS 5
BP 740
EP 748
DI 10.1111/iwj.12921
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GU0OU
UT WOS:000444951400008
PM 29863305
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Sukur, E
   Akar, A
   Uyar, AÇ
   Cicekli, O
   Kochai, A
   Turker, M
   Topcu, HN
AF Sukur, Erhan
   Akar, Abdulhalim
   Uyar, Ahmet Cagri
   Cicekli, Ozgur
   Kochai, Alauddin
   Turker, Mehmet
   Topcu, Huseyin Nevzat
TI Vacuum-assisted closure versus moist dressings in the treatment of
   diabetic wound ulcers after partial foot amputation: A retrospective
   analysis in 65 patients
SO JOURNAL OF ORTHOPAEDIC SURGERY
LA English
DT Article
DE diabetic food ulcer; partial foot amputation; reamputation; VAC
ID THERAPY; SURGERY
AB Purpose: Changes in weight-bearing patterns after partial foot amputations may lead to new localized high-pressure points and keratosis due to ulcerations in patients with neuropathies and hypovascular limbs. As a result, diabetic foot ulcers (DFUs) after partial foot amputations are very complex. The aim of this study was to compare the effectiveness of vacuum-assisted closure (VAC) therapy with conventional moist wound dressings in the treatment of diabetic wound ulcers after partial foot amputations. Methods: Sixty-five diabetic patients with a DFU, who had previously undergone partial foot amputation surgery, were assigned to treatment with VAC (group A: 31 patients) or conventional wound moist dressing (group B: 34 patients). The final results were considered as failed treatment if reamputation was required. Conversely, reaching 90% of wound granulation was considered to be a successful endpoint. Results: The average time to reach 90% granulation tissue was significantly lower in group A (7.8 +/- 1.2 weeks vs. 11.1 +/- 1.2 weeks; p < 0.001). However, there was no significant difference regarding the reamputation requirements; 38.7% (12 patients) in group A and 41.2% (14 patients) in group B, (p = 0.839). Conclusion: The results of this study allowed us to conclude that VAC therapy system appears to be an effective treatment for patients with complex DFUs who had previously undergone partial foot amputation.
C1 [Sukur, Erhan; Akar, Abdulhalim; Uyar, Ahmet Cagri; Cicekli, Ozgur; Kochai, Alauddin; Turker, Mehmet; Topcu, Huseyin Nevzat] Sakarya Univ Res & Training Hosp, Dept Orthopaed & Traumatol, Sakarya, Turkey.
C3 Sakarya University
RP Sukur, E (通讯作者)，Sakarya Univ Res & Training Hosp, Dept Orthopaed & Traumatol, TR-54050 Adapazari, Sakarya, Turkey.
EM erhan_sukur@hotmail.com
RI çiçekli, özgür/C-9200-2019; Kochai, alauddin/LSL-9483-2024; Akar,
   Abdulhalim/MXL-2024-2025
OI çiçekli, özgür/0000-0001-8063-6866; Akar, Abdulhalim/0000-0002-3153-4799
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Wagner F W Jr, 1981, Foot Ankle, V2, P64
NR 20
TC 6
Z9 8
U1 1
U2 24
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1022-5536
EI 2309-4990
J9 J ORTHOP SURG-HONG K
JI J. Orthop. Surg.
PD SEP 20
PY 2018
VL 26
IS 3
AR 2309499018799769
DI 10.1177/2309499018799769
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA GU4UR
UT WOS:000445280800001
PM 30235975
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Nolff, MC
   Alberti, R
   Wohlsein, P
   Baumgärtner, W
   Reese, S
   Meyer-Lindenberg, AM
AF Nolff, M. C.
   Alberti, R.
   Wohlsein, P.
   Baumgaertner, W.
   Reese, S.
   Meyer-Lindenberg, A.
TI Histomorphometric evaluation of MMP-9 and CD31 expression during healing
   under Negative Pressure Wound Therapy in dogs
SO SCHWEIZER ARCHIV FUR TIERHEILKUNDE
LA English
DT Article
DE negative Pressure Wound Therapy; open wound treatment;
   neovascularisation; matrix-metalloproteinase 9; dog
ID VACUUM-ASSISTED CLOSURE; BLOOD-FLOW; MATRIX; RESPONSES; MECHANISM
AB The aim of the study was to evaluate the molecular and histological effects of negative pressure wound therapy (NPWT) on vascularisation in clinical cases of open wound treatment in dogs. Open wounds (n=10) were randomly assigned to one of two groups: NPWT treatment (n=5) or foam treatment (polyurethane-foam dressing, n=5). Wounds were matched based on age and underlying cause and analysed with respect to neovascularisation (CD31) and matrix proteinase changes (MMP-9). Histological slides were blinded and analysis was performed using automated histomorphometric software. Values determined at day zero after debridement were used as a reference and wound development at day six was evaluated using linear mixed models. Signalment, pre-treatment time and underlying cause were similar between groups. NPWT resulted in a highly significant increase of vascularisation (p<0.001) compared to controls, in which mean vascularization indices decreased from day one to day six. MMP-9 activity decreased from day 0 to 6 with no significant differences between groups. This study indicates that NPWT exerts a substantial effect on vascularisation and tissue organization within wounds in dogs.
C1 [Nolff, M. C.; Alberti, R.; Meyer-Lindenberg, A.] Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Germany.
   [Wohlsein, P.; Baumgaertner, W.] Univ Vet Med Hannover, Dept Pathol, Hannover, Germany.
   [Reese, S.] Ludwig Maximilians Univ Munchen, Dept Basic Vet Sci, Munich, Germany.
C3 University of Munich; University of Veterinary Medicine Hannover;
   University of Munich
RP Nolff, MC (通讯作者)，Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Germany.
EM m.nolff@lmu.de
RI Meyer-Lindenberg, Andreas/H-1076-2011; Reese, Sven/F-1826-2016; Nolff,
   Mirja/W-6756-2019
OI Reese, Sven/0000-0002-4605-9791; Nolff, Mirja/0000-0001-9317-7769;
   Baumgärtner, Wolfgang/0000-0001-8151-5644
FU 'Gesellschaft zur Forderung Kynologischer Forschung e.V.'
FX The study was partly funded by the 'Gesellschaft zur Forderung
   Kynologischer Forschung e.V.' The funders were not involved in study
   design, data collection and analysis as well as writing of the
   manuscript. Furthermore, the authors want to thank Dr. Monir Majzoub for
   his assistance in processing the specimens.
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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NR 24
TC 4
Z9 5
U1 0
U2 10
PU GESELLSCHAFT SCHWEIZER TIERARZTINNEN & TIERARZTE
PI BERN
PA BRUCKFELDSTRASSE 18, BERN, CH-3012, SWITZERLAND
SN 0036-7281
EI 1664-2848
J9 SCHWEIZ ARCH TIERH
JI Schweiz. Arch. Tierheilkd.
PD SEP
PY 2018
VL 160
IS 9
BP 525
EP 532
DI 10.17236/sat00173
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA GU5IL
UT WOS:000445319100008
PM 30206048
DA 2026-07-24
ER
PT J
AU Tian, Y
   Liu, T
   Zhao, CQ
   Lei, ZY
   Fan, DL
   Mao, TC
AF Tian, Yuan
   Liu, Ting
   Zhao, Chuan-qi
   Lei, Ze-yuan
   Fan, Dong-li
   Mao, Tong-chun
TI Negative pressure wound therapy and split thickness skin graft aided in
   the healing of extensive perineum necrotizing fasciitis without faecal
   diversion: a case report
SO BMC SURGERY
LA English
DT Article
DE Perineum necrotizing fasciitis; Fournier gangrene; Negative pressure
   wound therapy; Skin graft; Faecal diversion
ID FOURNIERS-GANGRENE; MANAGEMENT; DRESSINGS; ULCERS
AB Background: Perineum necrotizing fasciitis, also known as Fournier gangrene (FG), is a rare but highly mortal infectious necrotizing fasciitis with or without involvement of the underlying muscle. Evidence exists that negative pressure wound therapy (NPWT) combined with a split thickness skin graft (STSG) can help to heal wounds with FG. However, when the wound spreads to the anal area, it can easily be contaminated by faeces, causing a more extensive wounds; thus, faecal diversion is considered. Here, we report a case of extensive perineum necrotizing fasciitis that spread to near the anus; NPWT combined with STSGs was used to help heal the wound without faecal diversion.
   Case presentation: A 47-year-old male patient was admitted with extensive perineum fascia necrosis caused by Pseudomonas aeruginosa that rapidly spread to near the anus. After comprehensive therapy completed wound bed preparation, STSGs from the scalp were grafted to the wound, and NPWT was applied to improve STSGs survival and seal the anus without faecal diversion.
   After treatment, graft take was 95%, and the exposed testicular and residual wounds were repaired with a local skin flap. At discharge, the wound had decreased to two pea-sized areas. The patient received conventional moist gauze therapy to close the residual wound at the local hospital. A follow-up by telephone 1 month later showed that both wounds had healed and that the patient was satisfied with the outcome.
   Conclusion: NPWT use combined with STSGs to cover the whole wound and the anus without faecal diversion is a safe and effective method to help with wound healing and avoid contamination with excrement.
C1 [Tian, Yuan; Liu, Ting; Zhao, Chuan-qi; Lei, Ze-yuan; Fan, Dong-li; Mao, Tong-chun] Army Med Univ, Dept Plast & Cosmet Surg, Xinqiao Hosp, Xinqiao Rd, Chongqing 400037, Peoples R China.
C3 Army Medical University
RP Mao, TC (通讯作者)，Army Med Univ, Dept Plast & Cosmet Surg, Xinqiao Hosp, Xinqiao Rd, Chongqing 400037, Peoples R China.
EM wei_dao1234@163.com
RI Tian, Yuan/IAN-7537-2023
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NR 14
TC 8
Z9 9
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD SEP 24
PY 2018
VL 18
AR 77
DI 10.1186/s12893-018-0411-6
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GU6WC
UT WOS:000445457100002
PM 30249225
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Boyar, V
AF Boyar, Vita
TI Treatment of Dehisced, Thoracic Neonatal Wounds With Single-Use Negative
   Pressure Wound Therapy Device and Medical-Grade Honey A Retrospective
   Case Series
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Dehiscence; Honey; Negative pressure wound therapy; Neonate
ID CONGENITAL HEART-DISEASE; VACUUM-ASSISTED CLOSURE; PEDIATRIC WOUNDS;
   MANAGEMENT; EXPERIENCE; TRAUMA; CARE; NPWT
AB PURPOSE: The purpose of this study was to report on our experience with a portable, single-use negative pressure wound therapy device used in combination with activated active Leptospermum honey (ALH) in the treatment of colonized or infected, dehisced, thoracic wounds in neonates with complex congenital heart disease.
   DESIGN: Retrospective, descriptive study.
   SUBJECTS AND SETTING: We reviewed medical records of 18 neonates and reported on findings from 11; the remaining 7 were not included secondary to incomplete records, transfer to a different institution prior to wound healing, or death. The median age of our patients was 12 days (range, 2 days to 5 weeks); their mean gestational age was 34 weeks. Al of the neonates had acquired postoperative wound dehiscence that were colonized or infected and were treated in the neonatal intensive care unit (NICU) at Cohen Children's Medical Center (New Hyde Park, New York), a regional perinatal center with a level 4 NICU.
   METHODS: Wound cultures were obtained on all patients prior to treatment commencement. All cultures were repeated on day 4 of treatment. Systemic antibiotics were administered as necessary. No complications were observed related to the use of negative pressure wound therapy device and ALH. Al patients were followed until discharge home or transfer to another facility. The pain scores during placement and removal were acceptable (between 1 and 3; median = 2) using the Neonatal Infant Pain Scale. Staff and parents indicated that the combination of ALH and the negative pressure wound therapy device did not interfere with daily care and parental bonding.
   CONCLUSIONS: Use of ALH and a single-use negative pressure wound therapy device was successful in this series of 11 neonates with complex congenital heart disease.
C1 [Boyar, Vita] Cohen Childrens Med Ctr New York, Div Neonatal Perinatal Med, Dept Pediat, New Hyde Pk, NY USA.
   [Boyar, Vita] Hofstra North Shore LIJ Sch Med, Hempstead, NY USA.
C3 Northwell Health; North Shore University Hospital; Steven & Alexandra
   Cohen Children's Medical Center of New York; Hofstra University;
   Northwell Health
RP Boyar, V (通讯作者)，269-01 76 Ave,Ste 344, New Hyde Pk, NY 11040 USA.
EM VBoyar@gmail.com
RI Boyar, Vita/J-5657-2019
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NR 32
TC 5
Z9 7
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAR-APR
PY 2018
VL 45
IS 2
BP 117
EP 122
DI 10.1097/WON.0000000000000407
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA GU8HS
UT WOS:000445579800003
PM 29521921
DA 2026-07-24
ER
PT J
AU Riechelmann, F
   Kaiser, P
   Arora, R
AF Riechelmann, F.
   Kaiser, P.
   Arora, R.
TI Primary soft tissue management in open fracture
SO OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE
LA German
DT Article
DE Wound closure; Wound infection; Debridement; Irrigation; Lavage
ID PRESSURE WOUND THERAPY; OPEN TIBIAL FRACTURES; SURGICAL DEBRIDEMENT;
   PRIMARY CLOSURE; DEEP INFECTION; OPEN INJURIES; LIMB SALVAGE; TRAUMA;
   METAANALYSIS; SCORE
AB ObjectiveDebridement of soft tissue and bone in an open fracture situation to minimize infection risk and achieve primary skin closure, or to provide conditions for early soft tissue coverage.IndicationsIndications are Gustilo-Anderson gradeI-IIIA-C open fractures.ContraindicationsContraindications are injuries requiring amputation, burns, and life-threatening injuries which make appropriate treatment temporarily impossible.Surgical techniqueRemoval of gross contamination and macroscopic contaminants; debridement of the wound; complete resection of contaminated and dirty tissue; sparse step-by-step resection of contaminated or non-vital wound and bone margins until vital, bleeding tissue begins; low-pressure irrigation with isotonic irrigation fluid; diagnostic biopsies for microbiological testing; reduction of dead space by interpositioning of muscle or cement spacers loaded with local antibiotics; primary wound closure if tension-free closure possible; otherwise, if resources and knowhow permit and satisfactory clean debridement was achieved, local flap; if flap impossible, debridement not satisfactory, secondary tissue necrosis likely, potential remaining contamination or contamination with fecal matter, then vacuum-assisted closure therapy.Postoperative managementWound inspection on the second postoperative day, generous indication for second-look surgery after 36-48h, wound inspection on the second postoperative day, wound inspection every other day, primary antibiotic prophylaxis with afirst- or second-generation cephalosporin (e.g., cefuroxime), and adaptation of antibiotic therapy according to susceptibility screening.ResultsInfection rates of 2-4.7% are reported for immediate primary wound closure in Gustilo-Anderson gradeI, II, and IIIA open fractures. For Gustilo-Anderson gradeIIIB, good wound healing, bony consolidation, and no need for secondary surgery was reported in 86.7% when primary wound closure was achieved.
C1 [Riechelmann, F.; Kaiser, P.; Arora, R.] Med Univ Innsbruck, Univ Klin Unfallchirurg, Anichstr 35, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck
RP Riechelmann, F (通讯作者)，Med Univ Innsbruck, Univ Klin Unfallchirurg, Anichstr 35, A-6020 Innsbruck, Austria.
EM felix.riechelmann@tirol-kliniken.at
OI Arora, Rohit/0000-0002-4843-7303
FU University of Innsbruck; Medical University of Innsbruck
FX Open access funding provided by University of Innsbruck and Medical
   University of Innsbruck.
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NR 48
TC 12
Z9 22
U1 0
U2 6
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0934-6694
EI 1439-0981
J9 OPER ORTHOP TRAUMATO
JI Oper. Orthopade Traumatol.
PD OCT
PY 2018
VL 30
IS 5
BP 294
EP 308
DI 10.1007/s00064-018-0562-8
PG 15
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA GV0WC
UT WOS:000445784500002
PM 30182178
OA hybrid
DA 2026-07-24
ER
PT J
AU Zwanenburg, PR
   Tol, BT
   de Vries, FEE
   Boermeester, MA
AF Zwanenburg, Pieter R.
   Tol, Berend T.
   de Vries, Fleur E. E.
   Boermeester, Marja A.
TI Incisional Negative Pressure Wound Therapy for Surgical Site Infection
   Prophylaxis in the Post-Antibiotic Era
SO SURGICAL INFECTIONS
LA English
DT Review
DE incision management; microbial resistance; negative pressure wound
   therapy; prophylaxis; prevention
ID VACUUM-ASSISTED CLOSURE; IMPROVEMENT PROJECT MEASURES; HIGH-RISK
   PATIENTS; MAJOR MUSCLE FLAP; COLORECTAL SURGERY; VASCULAR-SURGERY;
   MANAGEMENT-SYSTEM; INSPIRED OXYGEN; GENERAL-SURGERY; OBESE-PATIENTS
AB Background: With the prospect of antibiotic failure in the post-antibiotic era, strategies that prevent surgical site infection (SSI) are increasingly important. Current literature suggests that incisional Negative Pressure Wound Therapy (iNWPT) is a promising intervention. Methods: Based on published literature regarding iNPWT, its mechanisms of action, and clinical results, a narrative summary was built, including both the experimental as well as the clinical literature. Results: The experimental literature indicates that iNPWT provides a barrier against external contamination before re-epithelialization, increases blood flow and lymphatic clearance, and reduces edema. Meta-analyses of randomized studies indicate that iNWPT is effective in reducing SSI. We did not identify studies that assessed bacterial clearance during iNPWT in contaminated surgical sites, nor did we identify clinical studies that specified they omitted concomitant antibiotic prophylaxis. Conclusions: Moderate quality evidence indicates that iNWPT reduces SSI, although data without the concomitant use of antibiotic prophylaxis are lacking. The iNPWT is likely effective as a result of its barrier function and optimization of the surgical site micro-environment. For now, iNPWT is recommended for incorporation in SSI prevention bundles. The iNPWT as a substitute for antibiotic prophylaxis is not recommended currently. Further reduction of SSI by iNPWT will lessen the need for therapeutic use of antibiotic agents.
C1 [Zwanenburg, Pieter R.; Tol, Berend T.; de Vries, Fleur E. E.; Boermeester, Marja A.] Univ Amsterdam, Amsterdam Gastroenterol & Metab, Amsterdam Infect & Immun, Dept Surg,Amsterdam UMC, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands.
C3 University of Amsterdam
RP Boermeester, MA (通讯作者)，Univ Amsterdam, Amsterdam Gastroenterol & Metab, Amsterdam Infect & Immun, Dept Surg,Amsterdam UMC, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands.
EM m.a.boermeester@amc.nl
OI Boermeester, Marja/0000-0003-3890-8105
FU Acelity/KCI, San Antonio, TX; JJ/Ethicon; Acelity/KCI;
   Allergan/LifeCell; Ipsen; Baxter; Mylan; Bard
FX This work was supported by an institutional grant from Acelity/KCI, San
   Antonio, TX.M.A. Boermeester reports institutional grants from
   J&J/Ethicon, Acelity/KCI, Allergan/LifeCell, Ipsen, Baxter, Mylan, Bard,
   and is an advisory board member of J&J/Ethicon, Acelity/KCI, Bard, and
   Allergan/LifeCell, for research and expertise. P.R. Zwanenburg is a
   speaker for GD Medical Pharma BV and Hospithera NV (Negative Pressure
   Wound Therapy distribution companies). For B.T. Tol and F.E.E. de Vries,
   no competing financial interests exist.
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NR 141
TC 9
Z9 9
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD NOV
PY 2018
VL 19
IS 8
SI SI
BP 821
EP 830
DI 10.1089/sur.2018.212
EA SEP 2018
PG 10
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA HD8RY
UT WOS:000446012300001
PM 30272529
DA 2026-07-24
ER
PT J
AU Johnson, LS
   Chaar, M
   Ball, CG
   Perez, S
   Nicholas, JM
   Wyrzykowski, AD
   Rozycki, GS
   Feliciano, DV
   Dente, CJ
AF Johnson, Laura S.
   Chaar, Mitchell
   Ball, Chad G.
   Perez, Sebastian
   Nicholas, Jeffrey M.
   Wyrzykowski, Amy D.
   Rozycki, Grace S.
   Feliciano, David, V
   Dente, Christopher J.
TI Management of extremity fasciotomy sites prospective randomized
   evaluation of two techniques
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Fasciotomy; Shoelace technique; Wound closure; Vacuum-assisted closure
ID DELAYED PRIMARY CLOSURE; ACUTE COMPARTMENT SYNDROME; VESSEL LOOP
   SHOELACE; WOUND CLOSURE; ASSISTED CLOSURE; GRADUAL CLOSURE; DEVICE
AB Introduction: Morbidity from the treatment of extremity compartment syndrome is underappreciated. Closure technique effectiveness has yet to be definitively established.
   Methods: A randomized non-blinded prospective study was performed involving patients who underwent an extremity fasciotomy following trauma. Shoelace wounds were strapped with vessel loops under tension and VAC wounds were treated with a standard KCI VAC dressing. After randomization, patients returned to the OR every 96 h until primarily closed or skin grafted.
   Results: 21 patients were consented for randomization with 11 (52%) successfully closed at the first reoperation. After interim analysis the study was closed early with 5/5 (100%) of wounds treated with the shoelace technique closed primarily and only 1/9 (11%) of VAC wounds closed primarily (p = 0.003). Overall primary closure was achieved in 74% of patients.
   Conclusions: Aggressive attempts at wound closure lead to an increased early closure rate. For wounds that remain open after the first re-operation, a simple shoelace technique is more successful than a wound VAC for achieving same hospital stay skin closure. (c) 2018 Elsevier Inc. All rights reserved.
C1 [Johnson, Laura S.] Medstar Washington Hosp Ctr, Washington, DC 20010 USA.
   [Chaar, Mitchell] Jersey City Med Ctr, Jersey City, NJ USA.
   [Ball, Chad G.] Univ Calgary, Calgary, AB, Canada.
   [Nicholas, Jeffrey M.] Gwinnett Med Ctr, Lawrenceville, GA USA.
   [Wyrzykowski, Amy D.] Wellstar Med Grp, Atlanta, GA USA.
   [Rozycki, Grace S.] Indiana Univ, Indianapolis, IN 46204 USA.
   [Feliciano, David, V] Univ Maryland, Sch Med, Dept Surg, Shock Trauma Ctr, Baltimore, MD 21201 USA.
   [Johnson, Laura S.; Chaar, Mitchell; Ball, Chad G.; Perez, Sebastian; Nicholas, Jeffrey M.; Wyrzykowski, Amy D.; Rozycki, Grace S.; Feliciano, David, V; Dente, Christopher J.] Emory Univ, Sch Med, Grady Mem Hosp, Atlanta, GA USA.
   [Johnson, Laura S.; Chaar, Mitchell; Ball, Chad G.; Perez, Sebastian; Nicholas, Jeffrey M.; Wyrzykowski, Amy D.; Rozycki, Grace S.; Feliciano, David, V; Dente, Christopher J.] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA.
C3 MedStar Washington Hospital Center; University of Calgary; Indiana
   University System; Indiana University Indianapolis; University System of
   Maryland; University of Maryland Baltimore; Emory University; Emory
   University
RP Johnson, LS (通讯作者)，Medstar Washington Hosp Ctr, Burn Ctr, 110 Irving St NW 3B-55, Washington, DC 20010 USA.
EM laura.s.johnson@medstar.net; mitch_chaar@yahoo.com; ball.chad@gmail.com;
   sdperez@emory.edu; jnicholas@gwinnettmedicalgroup.com;
   amy.wyrzykowski@wellstar.org; grace.rozycki@att.net;
   davidfelicianomd@gmail.com; cdente@emory.edu
RI Johnson, Laura S/ABE-5478-2020
OI Johnson, Laura S/0000-0001-6969-2648
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NR 26
TC 10
Z9 13
U1 0
U2 6
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD OCT
PY 2018
VL 216
IS 4
BP 736
EP 739
DI 10.1016/j.amjsurg.2018.07.033
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GV9DG
UT WOS:000446453700015
PM 30064725
DA 2026-07-24
ER
PT J
AU Kement, M
   Baskiran, A
AF Kement, Metin
   Baskiran, Adil
TI Efficacy of negative pressure wound therapy in the management of acute
   burns
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Burn; grafting; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE
AB BACKGROUND: The aim of the present study was to evaluate the outcomes and efficacy of negative pressure wound therapy in the management of acute burns.
   METHODS: Patients with acute burns who have received negative pressure wound therapy at the Dr. Lutfi Kirdar Kartal Research and Training Hospital Tertiary Burn Care Center between January 2014 and December 2015 were included in the study. Patient data were retrospectively reviewed by analyzing data from our prospective patient database.
   RESULTS: A total of 38 patients were evaluated for the study. Three patients were excluded due to mortality prior to the completion of the treatment course. There were 32 (91.6%) male and 3 (8.4%) female patients. The mean age of the patients was 49.5 +/- 16 years. The etiological factors included electrical burn injury in 19 (54.3%), chemical burn injury in 7 (20%), flame burn injury in 6 (17.2%), and hot water burns in 3 (8.4%) patients. The severity of the burns was grade 3 or 4 in all of the patients included in the study. The mean duration of negative pressure wound therapy was 10.1 +/- 3.9 days. There were no procedure-related complications throughout the duration of the study. During the standard application of the device, one patient experienced local pain; therefore, low pressure (75 mmHg) was applied during therapy, and pressure was steadily increased. As a result of the application of this therapy, a decrease in the surface area, edema, and secretion of the wound and an increase in the granulation tissue and perfusion of the wound were observed in all treated patients. Wound cultures revealed no bacterial growth in any of the patients. The mean duration of surgical wound closure was 11.2 +/- 3.7 days. No complication was observed related to wound closure. The mean duration of hospital discharge in the postoperative period was 6.7 +/- 2.1 days.
   CONCLUSION: Well-designed, randomized control studies showing the efficacy of negative pressure wound therapy in patients with burns are lacking. The results of the present study showed that negative pressure wound therapy may reduce the number of wound debridement sessions, time of wound closure, and hospitalization in major burn injuries exposing the underlying tendons and bones.
C1 [Kement, Metin] Univ Hlth Sci, Dept Gen Surg, Kartal Dr Lutfi Kirdar Training & Res Hosp, Istanbul, Turkey.
   [Baskiran, Adil] Inonu Univ, Fac Med, Dept Gen Surg, Malatya, Turkey.
C3 University of Health Sciences Turkey; Istanbul Kartal Dr Lutfi Kirdar
   Training & Research Hospital; Inonu University
RP Baskiran, A (通讯作者)，Inonu Univ, Fac Med, Dept Gen Surg, Malatya, Turkey.
EM dr.adil.baskiran@gmail.com
RI Baskiran, Adil/ABI-2356-2020; Kement, Metin/LNR-5964-2024
OI Baskiran, Adil/0000-0002-7536-1631; Kement, Metin/0000-0003-4724-4945
CR Adamkova M, 2005, Acta Chir Plast, V47, P24
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   Voinchet V, 1996, Ann Chir Plast Esthet, V41, P583
   Xie X, 2010, J WOUND CARE, V19, P488
NR 15
TC 8
Z9 13
U1 2
U2 8
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD SEP
PY 2018
VL 24
IS 5
BP 412
EP 416
DI 10.5505/tjtes.2017.78958
PG 5
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA GV9UL
UT WOS:000446506600006
PM 30394493
OA Bronze
DA 2026-07-24
ER
PT J
AU Eyvaz, K
   Kement, M
   Balin, S
   Acar, H
   Kündes, F
   Karaoz, A
   Civil, O
   Eser, M
   Kaptanoglu, L
   Vural, S
   Bildik, N
AF Eyvaz, Kemal
   Kement, Metin
   Balin, Salim
   Acar, Hakan
   Kundes, Fikri
   Karaoz, Alev
   Civil, Osman
   Eser, Mehmet
   Kaptanoglu, Levent
   Vural, Selahattin
   Bildik, Nejdet
TI Clinical evaluation of negative-pressure wound therapy in the management
   of electrical burns
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Burn; electrical injury; NPWT
ID VACUUM-ASSISTED CLOSURE
AB BACKGROUND: In this study, we aimed to evaluate the clinical efficacy and safety of negative-pressure wound therapy (NPWT) in the treatment of the patients with electrical burns.
   METHODS: This study was retrospectively performed using a database placed prospectively in the burn center of our hospital. All consecutive patients with electrical burns treated using NPWT at our center between August 2008 and December 2012 were included. The treatment results in our study were grouped as successful or unsuccessful considering the treatment objectives in accordance with therapy indications.
   RESULTS: In total, 39 patients were included in our study; of them, 36 (92.3%) were men. The average age was 34.9 +/- 9.8 years (range, 17-63 years). The majority of the patients in our study (92.3%) had been exposed to high voltage electricity. The mean total burned body surface area (TBSA) was 19.3 +/- 9.8 (range, 4-44). Six patients (15.4%) had TBSAs >= 30%, 31 (79.5%) had third degree burns, and 8 (20.5%) had fourth degree burns. In our study, indications of NPWT included bone and/or tendon exposed deep wounds that are not suitable for early grafting or flap applications owing to the lack of supporting tissue in 27 (69.2%) patients, graft fixation in 8 (20.5%) patients, and secondary grafting following graft loss in 4 (10.3%) patients. The general success rate of NPWT was 90.7% according to indications and treatment objectives in our study.
   CONCLUSION: In the light of our results, NPWT may contribute to the present conventional treatments used in severe electrical burns.
C1 [Eyvaz, Kemal; Kement, Metin; Balin, Salim; Acar, Hakan; Kundes, Fikri; Karaoz, Alev; Civil, Osman; Eser, Mehmet; Kaptanoglu, Levent; Vural, Selahattin; Bildik, Nejdet] Kartal Dr Lutfi Kirdar Training & Res Hosp, Univ Hlth Sci, Dept Gen Surg, Istanbul, Turkey.
C3 Istanbul Kartal Dr Lutfi Kirdar Training & Research Hospital; University
   of Health Sciences Turkey
RP Kement, M (通讯作者)，Saglik Bilimleri Univ, Kartal Dr Lutfi Kirdar Training & Res Hosp, Istanbul, Turkey.
EM mkemet@yahoo.com
RI ; Kement, Metin/LNR-5964-2024; Eyvaz, Kemal/W-5052-2017; /AAP-7411-2020
OI Kaptanoglu, Levent/0000-0003-1059-9152; Kement,
   Metin/0000-0003-4724-4945; Eyvaz, Kemal/0000-0002-7410-107X; 
CR [Anonymous], 2 WORLD UN WOUND HEA
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NR 18
TC 10
Z9 15
U1 1
U2 5
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD SEP
PY 2018
VL 24
IS 5
BP 456
EP 461
DI 10.5505/tjtes.2018.80439
PG 6
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA GV9UL
UT WOS:000446506600014
PM 30394501
OA Bronze
DA 2026-07-24
ER
PT J
AU Alcala-Marquez, C
   Torrealba, R
   Mehbod, AA
   Dawson, JM
   Dressel, TD
   Transfeldt, EE
AF Alcala-Marquez, Christopher
   Torrealba, Ruben
   Mehbod, Amir A.
   Dawson, John M.
   Dressel, Thomas D.
   Transfeldt, Ensor E.
TI Recurrent Surgical Site Infections in the Spine After Treatment With the
   Vacuum-assisted Closure (VAC) System
SO CLINICAL SPINE SURGERY
LA English
DT Article
DE spine fusion; SSI; recurrent infection; VAC
ID DEEP WOUND-INFECTION; RISK-FACTORS; POSTOPERATIVE INFECTIONS; CONTINUOUS
   IRRIGATION; SURGERY; FUSION; INSTRUMENTATION; MANAGEMENT; THERAPY;
   COMPLICATIONS
AB Study Design: This study retrospectively reviewed recurrences of surgical site infections (SSI) in spinal patients treated with vacuum-assisted closure (VAC) technology.
   Objective: Identify patient and treatment factors associated with recurrence of SSI after VAC treatment.
   Summary of Background Data: Patients treated with VAC can achieve healing of deep spine wound infections; however, some patients develop a recurrent infection. Risk factors associated with a recurrence have not been identified.
   Materials and Methods: One hundred and eleven patients with SSI after spine surgery from 2002 to 2010 were studied. They had been treated with irrigation and debridement, placement of VAC, and IV antibiotics. They subsequently were taken to surgery for primary closure of their wound. Patients with SSI who healed after the initial infection treatment were compared with patients who experienced recurrence. Patient and treatment factors that were studied included smoking status, body mass index, obesity status, diagnosis of diabetes, fusion surgery, methicillin-resistant Staphylococcus aureus, or polybacteria infection, number of irrigation and debridement treatments before closure, duration of IV antibiotic treatment, and duration of treatment time with VAC. Patients with SSI who healed after the initial treatment were compared with patients who experienced recurrence.
   Results: Fourteen patients had at least one recurrence of wound infection. None of the patient or treatment factors was associated with the recurrence of a SSI.
   Conclusions: Among spine surgery patients with a SSI treated with the VAC system, those factors which predispose a patient to develop a recurrent SSI remain unknown.
C1 [Alcala-Marquez, Christopher; Torrealba, Ruben; Mehbod, Amir A.; Dawson, John M.; Dressel, Thomas D.; Transfeldt, Ensor E.] Twin Cities Spine Ctr, 913 E 26th St,Suite 600, Minneapolis, MN 55404 USA.
RP Dawson, JM (通讯作者)，Twin Cities Spine Ctr, 913 E 26th St,Suite 600, Minneapolis, MN 55404 USA.
EM jmdawson@tcspine.com
OI Dawson, John/0000-0002-9389-1580
CR Adogwa O, 2017, SPINE, V42, P520, DOI 10.1097/BRS.0000000000001779
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NR 35
TC 9
Z9 12
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2380-0186
J9 CLIN SPINE SURG
JI Clin. Spine Surg.
PD OCT
PY 2018
VL 31
IS 8
BP 351
EP 355
DI 10.1097/BSD.0000000000000668
PG 5
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA GW0BE
UT WOS:000446526000007
PM 29889107
DA 2026-07-24
ER
PT J
AU Nherera, LM
   Trueman, P
   Schmoeckel, M
   Fatoye, FA
AF Nherera, Leo M.
   Trueman, Paul
   Schmoeckel, Michael
   Fatoye, Francis A.
TI Cost-effectiveness analysis of single use negative pressure wound
   therapy dressings (sNPWT) compared to standard of care in reducing
   surgical site complications (SSC) in patients undergoing coronary artery
   bypass grafting surgery
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Single use negative pressure wound therapy; cost-effectiveness; Surgical
   site complications; CABG
ID METAANALYSIS; INFECTION
AB Background: There is a growing interest in using negative pressure wound therapy in closed surgical incision to prevent wound complications which continue to persist following surgery despite advances in infection measures.
   Objectives: To estimate the cost-effectiveness of single use negative pressure wound therapy (sNPWT) compared to standard of care in patients following coronary artery bypass grafting surgery (CABG) procedure to reduce surgical site complications (SSC) defined as dehiscence and sternotomy infections.
   Method: A decision analytic model was developed from the Germany Statutory Health Insurance payer's perspective over a 12-week time horizon. Baseline data on SSC, revision operations, length of stay, and readmissions were obtained from a prospective observational study of 2621 CABG patients in Germany. Effectiveness data for sNPWT was taken from a randomised open label trial conducted in Poland which randomised 80 patients to treatment with either sNPWT or standard care. Cost data (in Euros) were taken from the relevant diagnostic related groups and published literature.
   Results: The clinical study reported an increase in wounds that healed without complications 37/40 (92.5%) in the sNPWT compared to 30/40 (75%) patients in the SC group p = 0.03. The model estimated sNPWT resulted in 0.989 complications avoided compared to 0.952 and the estimated quality adjusted life years were 0.8904 and 0. 8593 per patient compared to standard care. The estimated mean cost per patient was (sic)19,986 for sNPWT compared to (sic)20,572 for SC resulting in cost-saving of (sic)586. The findings were robust to a range of sensitivity analyses.
   Conclusion: The sNPWT can be considered a cost saving intervention that reduces surgical site complications following CABG surgery compared to standard care. We however recommend that additional economic studies should be conducted as new evidence on the use of sNPWT in CABG patients becomes available to validate the results of this economic analysis.
C1 [Nherera, Leo M.; Trueman, Paul] Global Market Access, Smith & Nephew Adv Wound Management, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
   [Schmoeckel, Michael] Asklepios Klin St Georg Cardiac, Dept Heart Surg, Vasc & Diabet Ctr, Lohmuhlenstr 5, D-20099 Hamburg, Germany.
   [Fatoye, Francis A.] Manchester Metropolitan Univ, Dept Hlth Profess, Manchester, Lancs, England.
C3 Smith & Nephew; Manchester Metropolitan University
RP Nherera, LM (通讯作者)，Global Market Access, Smith & Nephew Adv Wound Management, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM leo.nherera@smith-nephew.com
RI ; Nherera, Leo/L-1978-2019
OI Fatoye, Francis/0000-0002-3502-3953; Nherera, Leo/0000-0003-1758-9504
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NR 22
TC 31
Z9 34
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD OCT 3
PY 2018
VL 13
AR 103
DI 10.1186/s13019-018-0786-6
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA GW0IT
UT WOS:000446547700004
PM 30285811
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Becker, CA
   Kammerlander, C
   Greiner, A
   Sommer, F
   Linhart, C
   Böcker, W
   Rubenbauer, B
   Weidert, S
AF Becker, Christopher A.
   Kammerlander, Christian
   Greiner, Axel
   Sommer, Fabian
   Linhart, Christoph
   Boecker, Wolfgang
   Rubenbauer, Bianka
   Weidert, Simon
TI Diagnostic and Treatment Strategies in Morel-Lavallee Lesions in the
   Spinal Column and Pelvis
SO ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
LA German
DT Article
DE pelvic fracture; spine fracture; soft tissue injury; closed degloving
   injury; Morel-Lavallee
ID SOFT-TISSUE INJURIES; CLOSED DEGLOVING INJURIES; OF-THE-LITERATURE;
   ACETABULAR FRACTURES; INTERNAL-FIXATION; WOUND CLOSURE; MANAGEMENT;
   TRAUMA
AB Background The Morel-Lavallee lesion is one of the concomitant soft tissue lesions of pelvic fractures. Its role in spine fractures and its treatment in combination with osteosynthesis of pelvic or spine fractures have not yet been determined. The aim of this study was to analyse the best diagnostic and treatment options of both spine and pelvic fractures combined with Morel-Lavallee lesions (MLL).
   Methods An analysis of the literature was performed via PubMed and Medline. This revealed a total of 197 studies and case reports. After analysing the literature, 19 studies/case reports met our inclusion criteria.
   Results There are several diagnostic options for MLL, including ultrasound, computed tomography or MRI. In spinal and pelvic lesions, ultrasound is capable of detecting MLL. Some authors tend to perform open debridement of the MLL, whereas others recommend percutanous treatment. Open debridement and vacuum-assisted closure are recommended in late diagnosed MLL, where primary suture of the soft tissue is impossible. Fracture fixation should be performed simultaneously to treatment of the MLL. Broad-spectrum cephalosporins combined with an aminoglycoside or piperacilline/tazobactam should be initiated.
   Conclusion Radical debridement and drainage are recommended, especially when MLL is diagnosed late. Repeated ultrasound examinations should be performed of the surrounding soft tissue of the fracture. When MU is diagnosed within 2 days, percutanous fracture and MU. treatment should be performed. After more than 2 days, both fracture and MLL should be treated with open debridement, open fracture fixation and primary suture if possible.
C1 [Becker, Christopher A.; Kammerlander, Christian; Greiner, Axel; Sommer, Fabian; Linhart, Christoph; Boecker, Wolfgang; Rubenbauer, Bianka; Weidert, Simon] Klinikum Ludwig Maximilians Univ Munchen, Klin Allgemeine Unfall Hand & Plast Chirurg, Munich, Germany.
RP Becker, CA (通讯作者)，Klin Allgemeine Unfall & Wiederherstellungschirur, Marchioninistr 15, D-81377 Munich, Germany.
EM christopher.becker@med.uni-muenchen.de
RI Kammerlander, Christian/Z-2246-2019
OI Linhart, Christoph/0000-0001-7349-7458
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NR 30
TC 3
Z9 5
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1864-6697
EI 1864-6743
J9 Z ORTHOP UNFALLCHIR
JI Z. Orthop. Unfallchir.
PD OCT
PY 2018
VL 156
IS 5
BP 541
EP 546
DI 10.1055/a-0596-8018
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA GW2NJ
UT WOS:000446720200016
PM 29649850
DA 2026-07-24
ER
PT J
AU Danno, K
   Matsuda, C
   Miyazaki, S
   Komori, T
   Nakanishi, M
   Motoori, M
   Kashiwazaki, M
   Fujitani, K
AF Danno, Katsuki
   Matsuda, Chu
   Miyazaki, Susumu
   Komori, Takamichi
   Nakanishi, Megumi
   Motoori, Masaaki
   Kashiwazaki, Masaki
   Fujitani, Kazumasa
TI Efficacy of Negative-Pressure Wound Therapy for Preventing Surgical Site
   Infections after Surgery for Peritonitis Attributable to
   Lower-Gastrointestinal Perforation: A Single-Institution Experience
SO SURGICAL INFECTIONS
LA English
DT Article
DE delayed primary closure; lower-gastrointestinal perforation; negative
   pressure wound therapy; prevention; surgical site infection
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; DELAYED PRIMARY
   CLOSURE; COLORECTAL SURGERY; INCISIONAL HERNIA; ABDOMINAL WOUNDS;
   APPENDICITIS; LAPAROTOMY; MANAGEMENT
AB Background and Purpose: For patients at high risk, such as those with lower-gastrointestinal perforations, it is important to establish a preventive method that reduces the incidence of surgical site infections (SSIs) significantly. We applied negative-pressure wound therapy (NPWT) as part of a delayed primary closure approach to prevent SSIs. This study evaluated the value of this technique.
   Methods: We included prospectively 28 patients undergoing abdominal surgery for peritonitis caused by a lower-gastrointestinal perforation between May 2014 and November 2015. Historical controls comprised retrospective data on 19 patients who had undergone primary suturing for managing peritonitis incisions for a lower-gastrointestinal perforation from January to December 2013.
   Results: We found a significant association between the SSI incidence and the type of incision management (10.7% with NPWT and delayed closure vs. 63.2% with primary suturing; p < 0.001). There was no significant difference between the groups in the length of the hospital stay (22 days for NPWT and delayed closure vs. 27 days for primary suturing; p = 0.45). No severe adverse events were observed related to NPWT.
   Conclusion: The use of NPWT and delayed primary closure was an effective measure for preventing SSI in patients undergoing abdominal surgery for peritonitis caused by lower-gastrointestinal perforation.
C1 [Danno, Katsuki; Miyazaki, Susumu; Komori, Takamichi; Motoori, Masaaki; Kashiwazaki, Masaki; Fujitani, Kazumasa] Osaka Gen Med Ctr, Dept Surg Gastroenterol, Osaka, Japan.
   [Nakanishi, Megumi] Osaka Gen Med Ctr, Dept Nursing, Osaka, Japan.
   [Matsuda, Chu] Osaka Univ, Grad Sch Med, Dept Surg Gastroenterol, Suita, Osaka, Japan.
C3 University of Osaka
RP Danno, K (通讯作者)，Minoh City Hosp, Dept Surg, 5-7-1 Kayano, Osaka 5620014, Japan.
EM danno_ka@yahoo.co.jp
CR [Anonymous], 2016, Global Guidelines for the Prevention of Surgical Site Infection
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NR 23
TC 14
Z9 19
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD OCT
PY 2018
VL 19
IS 7
BP 711
EP 716
DI 10.1089/sur.2018.134
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA GW5YH
UT WOS:000447018600012
PM 30183559
DA 2026-07-24
ER
PT J
AU Lee, R
   Beder, D
   Street, J
   Boyd, M
   Fisher, C
   Dvorak, M
   Paquette, S
   Kwon, B
AF Lee, Robert
   Beder, Daniel
   Street, John
   Boyd, Michael
   Fisher, Charles
   Dvorak, Marcel
   Paquette, Scott
   Kwon, Brian
TI The use of vacuum-assisted closure in spinal wound infections with or
   without exposed dura
SO EUROPEAN SPINE JOURNAL
LA English
DT Article
DE Vacuum-assisted closure; Spinal infection; Exposed dura
ID THERAPY; MANAGEMENT; FUSION; INSTRUMENTATION; COMPLICATIONS; SCOLIOSIS;
   SURGERY; ADULTS; DEFECT
AB Introduction The treatment of postoperative deep spinal wound infection involves debridement and intravenous antibiotics. Authors have previously reported success in a small series of patients treated with vacuum-assisted closure (VAC) therapy, but its use over exposed dura is controversial and the outcome has not been reported in large series.
   Purpose To review the outcomes following the treatment of postoperative spinal infections with VAC therapy, particularly those with exposed dura.
   Methods This is a review of prospectively collected data in 42 patients, all of whom had deep postoperative spinal infections. 30 of these patients had exposed dura. All patients had an initial debridement followed by application of VAC Whitefoam (with exposed dura) or grey Granufoam (where no dura was exposed). Pressure was set at 50 mmHg with exposed dura or 125 mmHg where no dura was exposed. All patients underwent a minimum 6 week course of antibiotics. We report on the number of visits to theatre required for dressing changes and debridement and the eventual outcomes.
   Results Five patients required a flap reconstruction. Two patients died before definitive final closure due to other complications (pneumonia and stroke). In all the other patients, their wounds healed fully. A mean of 2.3 infection surgeries were required to eradicate infection and achieve wound closure.
   Conclusions This is one of the largest studies which confirms the safety and efficacy of VAC dressings in patients with spinal wound infections, even when the dura is exposed.
C1 [Lee, Robert; Beder, Daniel] Royal Natl Orthopaed Hosp NHS Trust, Stanmore, Middx, England.
   [Street, John; Boyd, Michael; Fisher, Charles; Dvorak, Marcel; Paquette, Scott; Kwon, Brian] Vancouver Gen Hosp, Vancouver, BC, Canada.
C3 University of London; University College London; Royal National
   Orthopaedic Hospital NHS Trust; University of British Columbia
RP Lee, R (通讯作者)，Royal Natl Orthopaed Hosp NHS Trust, Stanmore, Middx, England.
EM robertlee1@nhs.net
OI Dvorak, Marcel/0000-0002-9404-8448
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NR 25
TC 25
Z9 28
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0940-6719
EI 1432-0932
J9 EUR SPINE J
JI Eur. Spine J.
PD OCT
PY 2018
VL 27
IS 10
BP 2536
EP 2542
DI 10.1007/s00586-018-5612-2
PG 7
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA GX1VT
UT WOS:000447507500015
PM 29696391
DA 2026-07-24
ER
PT J
AU Narkhede, PS
   Vivekanand
   Vishnu, M
   Sumanthraj, K
   Sravan, CPS
   Lende, V
   Agarwal, L
   Suresh, KR
AF Narkhede, Pravin Sakharam
   Vivekanand
   Vishnu, M.
   Sumanthraj, K.
   Sravan, C. P. S.
   Lende, Vaibhav
   Agarwal, Lawish
   Suresh, K. R.
TI Resource Utilization and Cost Effectiveness of Negative Pressure Wound
   Therapy (NPWT) Versus Moist Wound Therapy (MWT) in Management of
   Diabetic Foot Transmetatarsal Amputation (TMA)
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Vacuum dressing; Diabetic
   transmetatarsal amputation; Cost effectivity; Resource utilization
ID VACUUM-ASSISTED CLOSURE; ULCERS; TRIAL
AB To evaluate resource utilization and direct economic costs of care for patients treated with negative pressure wound therapy (NPWT) in comparison with standard moist wound therapy (MWT) for preparation of diabetic foot TMA wounds for skin grafting. We retrospectively analyzed 56 patients who underwent transmetatarsal amputation (TMA) for infected diabetic foot from January 2014 to April 2015 at Jain Institute of Vascular sciences (JIVAS), Bangalore. Twenty-eight patients received negative pressure wound therapy (NPWT) (VAC (R) KCI, TX, USA) dressing while 28 received standard MWT daily. Resource utilization, revascularization procedures, number of secondary procedures (debridement), and total cost for wound bed preparation were calculated in both groups. There was no significant difference in both groups regarding age, gender, comorbidities, and number of revascularization procedures. All patients were having ankle brachial index (ABI) more than 0.8 or ankle pressures more than 80mmHg before enrolling to study group. MWT group required more debridement (15 vs. 2; P=0.0001). Average number of dressing changes performed per patients were 25 (range 20-32) for MWT versus 3 (range 2-5) in NPWT group. MWT group had more OPD visits compare to NPWT (14 vs. 2; P value =0.0001). Mean duration for wound bed preparation was 24.61 +/- 3.20days (range 20-32days) in MWT group and significantly higher than NPWT group 9.11 +/- 2.38days (range 6-15days) (P=0.0001; 95% CI difference 13.99 to 17.01). The average total cost for wound bed preparation of TMA wound was Rs 26,875 +/- 6810.5 in MWT group and was significantly higher than compared to Rs 23,089.29 +/- 6637.5 in NPWT group (P=0.03; 95% CI difference 182.54 to 7388.89). NPWT resulted in lower resource utilization, reduced costs, and acceleration of wound bed preparation for diabetic foot TMA wound in comparison to standard MWT.
C1 [Narkhede, Pravin Sakharam; Vivekanand; Vishnu, M.; Sumanthraj, K.; Sravan, C. P. S.; Lende, Vaibhav; Agarwal, Lawish; Suresh, K. R.] Jain Inst Vasc Sci JIVAS, Dept Vasc & Endovasc Surg, Bengaluru 560052, India.
RP Narkhede, PS (通讯作者)，Jain Inst Vasc Sci JIVAS, Dept Vasc & Endovasc Surg, Bengaluru 560052, India.
EM drpravin7474@gmail.com; jainvascular@hotmail.com;
   narkhede_pravin@yahoo.com; sumanthkolalu@yahoo.co.in;
   sravan_cps@yahoo.co.in; vaibhavinpeds@gmail.com; kalsuresh48@gmail.com
RI Madhu, Vishnu/AAX-6620-2021
CR Amit kumar CJain, 2011, J DIABETIC FOOT COMP, V3, P13
   [Anonymous], 2012, 2012 WOUND CARE PROD
   [Anonymous], 2000, J FOOT ANKLE SURG S5
   [Anonymous], 2011, 2011 WOUND CARE PROD
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NR 22
TC 1
Z9 1
U1 0
U2 19
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD OCT
PY 2018
VL 80
IS 5
BP 457
EP 460
DI 10.1007/s12262-017-1630-2
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GX4SX
UT WOS:000447726900011
DA 2026-07-24
ER
PT J
AU Egin, S
   Gökçek, B
   Yesiltas, M
   Hot, S
   Kamali, S
   Isil, RG
   Tok, H
   Karahan, SR
AF Egin, Seracettin
   Gokcek, Berk
   Yesiltas, Metin
   Hot, Semih
   Kamali, Sedat
   Isil, Riza Gurhan
   Tok, Hasan
   Karahan, Servet Rustu
TI THE FACTORS AFFECTING SURVIVAL IN OPEN ABDOMEN DUE TO SURGICAL ABDOMINAL
   SEPSIS
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Abdominal sepsis; Open abdomen; Vacuum-assisted closure; Negative
   pressure therapy
ID COMPARTMENT SYNDROME; MANAGEMENT; GUIDELINES; SOCIETY; CLOSURE
AB Introduction: In the literature, there are studies comparing open abdomen technique and primary closure technique in terms of survival and other results in patients with surgical abdominal sepsis. There are no studies investigating the factors affecting survival in patients treated with open abdominal technique alone. These factors should be investigated retrospectively in open abdomen patients. We aimed to investigate the factors of survival in patients with severe intraabdominal sepsis treated with vacuum-assisted closure systems for open abdomen. We hypothesized that use of open abdomen with vacuum-assisted closure systems was reduced mortality in patients with severe intraabdominal sepsis.
   Materials and methods: We retrospectively reviewed 40 open abdomen patients performed vacuum-assisted closure for severe intraabdominal sepsis. Alive and mortal groups were evaluated in terms of age, gender, body mass index, etiology of surgical abdominal sepsis, Apache II score, Mannheim peritonitis index score, Bjorck classification, fascia score, abdominal defect size, stoma and fistula presence, and vacuum-assisted closure treatment duration. It was evaluated whether any of these parameters was effective on survival.
   Results: Mean age and body mass index were significantly elevated in the mortal group compared with the alive group. A significant difference with regard to Bjorck classification was detected between the alive and mortal groups. In Bjorck 1 and 2, mortality rates were 36.8% and 31.3%, respectively, while in Bjorck 4, mortality was 100%. The presence and ope of fistula were statistically significant for mortality. None of the other parameters were statistically significant for mortality.
   Discussion: The studies of the last twelve years showed that the open abdomen technique with the temporary abdominal wall closure using negative pressure dressing methods gave positive results. The 42.5% mortality rate in our study is much lower than the mortality rate for abdominal sepsis patients in the literature. Our study indicated that the management of open abdomen and negative pressure therapy was possible to increase the survival in patients with surgical abdominal sepsis.
C1 [Egin, Seracettin; Gokcek, Berk; Yesiltas, Metin; Hot, Semih; Kamali, Sedat; Isil, Riza Gurhan; Tok, Hasan; Karahan, Servet Rustu] Saglik Bilimleri Univ, Okmeydani Educ & Res Hosp, Darulaceze Cad 25, TR-34384 Istanbul, Turkey.
C3 Istanbul Okmeydani Training & Research Hospital; University of Health
   Sciences Turkey
RP Egin, S (通讯作者)，Saglik Bilimleri Univ, Okmeydani Educ & Res Hosp, Darulaceze Cad 25, TR-34384 Istanbul, Turkey.
EM seracettin_egin@hotmail.com
RI /ADG-3811-2022; /R-3639-2018; Gökçek, Berk/X-9343-2018; Eğin,
   Seracettin/GQZ-0908-2022; Kamalı, Sedat/GRS-4734-2022
OI Gökçek, Berk/0000-0001-9989-4152; 
CR Adkins AL, 2004, AM SURGEON, V70, P137
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   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
   Vargo D, 2009, AM SURGEON, V75, pS1
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2018
VL 34
IS 6
BP 2031
EP 2036
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GX5TR
UT WOS:000447814400068
DA 2026-07-24
ER
PT J
AU Chen, X
   Liu, L
   Nie, W
   Deng, R
   Li, J
   Fu, Q
   Fei, J
   Wang, C
AF Chen, X.
   Liu, L.
   Nie, W.
   Deng, R.
   Li, J.
   Fu, Q.
   Fei, J.
   Wang, C.
TI Vacuum Sealing Drainage Therapy for Refractory Infectious Wound on 16
   Renal Transplant Recipients
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article; Proceedings Paper
CT 15th Congress of the Asian-Society-of-Transplantation (CAST)
CY NOV 27-30, 2017
CL Cebu, PHILIPPINES
SP Asian Soc Transplantat
ID NEGATIVE-PRESSURE THERAPY; SURGICAL SITE INFECTION; COMPLICATIONS
AB Background. Refractory infectious wounds on renal transplantation (RT) recipients significantly prolong hospital stay, increase medical costs, and threaten allograft survival. Vacuum sealing drainage (VSD) therapy is a new technique for managing wounds based on the principle of application of controlled negative pressure. The aim of this study was to summarize the efficacy and safety of VSD therapy in the management of refractory infectious wounds following RT.
   Materials and methods. This is a retrospective study of a cohort of 661 consecutive patients who received renal transplants over a period of 3 years in which the data were collected and analyzed retrospectively.
   Results. Out of the 661 patients, 16 (2.4%) developed refractory wound infection following RT. Nineteen organisms were identified by culture from all patients, including 10 patients infected with 1 or more bacteria, 2 patients with fungal infection, and 4 patients with both. Specifically, mucormycosis was demonstrated in 4 patients, pan-resistant Klebsiella pneumoniae in 2 patients, and Acinetobacter baumannii in 2 patients. All 16 patients were treated with VSD therapy for a median of 37 days (range, 6 - 111 days). The number of VSD sets used ranged from 4 to 28 sets (mean, 11.1 sets). A combination of antibiotics, debridement, and VSD therapy lead to 100% (16 of 16) wound healing. No VSD-relevant adverse events were observed.
   Conclusions. VSD therapy is an effective and safe adjunct to conventional treatment modalities for the management of refractory wound infection following RT.
C1 [Chen, X.; Liu, L.; Nie, W.; Deng, R.; Li, J.; Fu, Q.; Fei, J.; Wang, C.] Sun Yat Sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Wang, C (通讯作者)，58 Zhongshan Rd 2, Guangzhou, Guangdong, Peoples R China.
EM wangchx@mail.sysu.edu.cn
FU National Natural Science Foundation of China [81670680]; Science and
   Technology Planning Project of Guangdong Province, China
   [20146020212006, 2015B020226002]; Science and Technology Program of
   Guangzhou, China [2014Y2-00114]; Guangdong Provincial Key Laboratory on
   Organ Donation and Transplant Immunology [2013A 061401007]
FX This work was supported by the National Natural Science Foundation of
   China (81670680), Science and Technology Planning Project of Guangdong
   Province, China (20146020212006, 2015B020226002), Science and Technology
   Program of Guangzhou, China (2014Y2-00114), and the Guangdong Provincial
   Key Laboratory on Organ Donation and Transplant Immunology (2013A
   061401007).
CR Castrechini Fernandes Franieck M. L., 2014, CHILD DEV RES, V2014, P1, DOI DOI 10.1155/2014/861703
   Condé-Green A, 2013, ANN PLAS SURG, V71, P394, DOI 10.1097/SAP.0b013e31824c9073
   Glass GE, 2014, BJS-BRIT J SURG, V101, P1627, DOI 10.1002/bjs.9636
   Harris AD, 2015, INFECT CONT HOSP EP, V36, P417, DOI 10.1017/ice.2014.77
   Ho D, 2010, J AM COLL SURGEONS, V211, P99, DOI 10.1016/j.jamcollsurg.2010.02.055
   Kim PJ, 2013, PLAST RECONSTR SURG, V132, P1569, DOI 10.1097/PRS.0b013e3182a80586
   Kontoyiannis DP, 2011, BLOOD, V118, P1216, DOI 10.1182/blood-2011-03-316430
   Loaec E, 2014, EUR ANN OTORHINOLARY, V131, P351, DOI 10.1016/j.anorl.2013.12.001
   Lopau K, 2010, KIDNEY BLOOD PRESS R, V33, P52, DOI 10.1159/000289573
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   Ortiz J, 2011, AM J TRANSPLANT, V11, P412, DOI 10.1111/j.1600-6143.2010.03362.x
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   Shrestha B M, 2007, Kathmandu Univ Med J (KUMJ), V5, P4
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   Ueno P, 2017, TRANSPLANTATION, V101, P844, DOI 10.1097/TP.0000000000001392
NR 16
TC 11
Z9 16
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD OCT
PY 2018
VL 50
IS 8
BP 2479
EP 2484
DI 10.1016/j.transproceed.2018.04.014
PG 6
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Immunology; Surgery; Transplantation
GA GX7MY
UT WOS:000447959000054
PM 30316382
DA 2026-07-24
ER
PT J
AU Hu, XX
   Lian, WS
   Zhang, XJ
   Yang, X
   Jiang, JX
   Li, MQ
AF Hu, Xiaoxiao
   Lian, Weishuai
   Zhang, Xiaojun
   Yang, Xue
   Jiang, jinxia
   Li, Maoquan
TI Efficacy of negative pressure wound therapy using vacuum-assisted
   closure combined with photon therapy for management of diabetic foot
   ulcers
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE diabetic foot ulcer; vacuum-assisted closure; photon therapy
ID PERIPHERAL NEUROPATHY; MELLITUS; RISK
AB Badcground: Diabetes mellitus, one of the most prevalent chronic metabolic diseases, causes many complications. Among the complications, one of the most common chronic complications is diabetic foot ulcers (DFUs).
   Objective: This study was conducted to investigate the efficacy of negative pressure wound therapy using vacuum-assisted closure (VAC) combined with photon therapy for the management of DFUs.
   Patients and methods: The study included a total of 69 patients with DFUs during the period from January 2014 to December 2015. All patients were diagnosed with DFUs with Wagner's stage 2 or 3 and were divided into two groups - the VAC group in which patients received only VAC and the combined group in which patients received both VAC and photon therapy. Data on duration of the treatment, pre- and postoperative wound surface areas, dressing changing times, pain conditions assessed using visual analog scale scores, recurrence rate and amputation rate were collected.
   Results: Among all patients, 35 patients were divided into the VAC group and 34 patients into the combined group. Areas of foot ulcers for all patients ranged from 5 to 100 cm(2). The treatment duration, dressing changing times and the peak value of visual analog scale scores were all significantly lower in the combined group compared with the VAC group (P<0.05). However, the reduced area for wound surface showed no significant difference between the two groups. Both recurrence and amputation rates showed no significant difference between the two groups of patients.
   Conclusion: Both VAC and VAC combined with photon therapy were effective and safe in the treatment of DFUs, while the combined therapy might have accelerated wound healing, but did not influence the long-term efficacy.
C1 [Hu, Xiaoxiao; Lian, Weishuai; Li, Maoquan] Tongji Univ, Sch Med, Peoples Hosp 10, Dept Intervent Vasc Surg, 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China.
   [Zhang, Xiaojun] Tongji Univ, Peoples Hosp 10, Dept Intervent Catheter, Shanghai 200072, Peoples R China.
   [Yang, Xue] Tongji Univ, Eastern Hosp, Dept Anesthesiol, Shanghai 200120, Peoples R China.
   [Jiang, jinxia] Tongji Univ, Peoples Hosp 10, Dept Emergency, 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China.
C3 Tongji University; Tongji University; Tongji University; Tongji
   University
RP Li, MQ (通讯作者)，Tongji Univ, Sch Med, Peoples Hosp 10, Dept Intervent Vasc Surg, 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China.; Jiang, JX (通讯作者)，Tongji Univ, Peoples Hosp 10, Dept Emergency, 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China.
EM jiangjiroda99@163.com; cjr.limaoquan@vip.163.com
RI Hu, Xiaoxiao/HPG-3615-2023
FU project (The Mechanism of LncRNA-MALAT1 Regulating Endothelial
   Progenitor Cells Biological Function in Diabetic Angiopathies)
   [81671793]; Fundamental Research Funds for the Central Universities
   [22120170092]
FX This work was supported by the project (The Mechanism of LncRNA-MALAT1
   Regulating Endothelial Progenitor Cells Biological Function in Diabetic
   Angiopathies) No 81671793 and the Fundamental Research Funds for the
   Central Universities (No 22120170092).
CR Alavi A, 2014, J AM ACAD DERMATOL, V21, pe21
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NR 25
TC 8
Z9 9
U1 1
U2 22
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2018
VL 14
BP 2113
EP 2118
DI 10.2147/TCRM.S164161
PG 6
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA GY1RP
UT WOS:000448309900001
PM 30498354
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sheckter, CC
   Pridgen, B
   Li, A
   Curtin, C
   Momeni, A
AF Sheckter, Clifford C.
   Pridgen, Brian
   Li, Alexander
   Curtin, Catherine
   Momeni, Arash
TI Regional Variation and Trends in the Timing of Lower Extremity
   Reconstruction: A 10-Year Review of the Nationwide Inpatient Sample
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Review
ID PRESSURE WOUND THERAPY; OPEN TIBIAL FRACTURES; MICROSURGICAL
   RECONSTRUCTION; ADMINISTRATIVE DATA; MANAGEMENT; SURGERY; TRAUMA;
   COVERAGE
AB Background: The ideal timing of soft-tissue coverage for open lower extremity fractures remains controversial. Using U.S. national data, this study aims to characterize secular trends and regional variation in the timing of soft-tissue coverage.
   Methods: Using discharge data from the Nationwide Inpatient Sample (2002 to 2011), the authors identified 888 encounters admitted from the emergency department with isolated open lower extremity fractures treated with pedicled or free tissue transfer. Soft-tissue coverage timing was assessed by patient factors, hospital characteristics, and fracture patterns. Statistical significance and secular trends were analyzed with generalized linear models.
   Results: The mean day of soft-tissue reconstruction was at 6.64 days. Over the 10-year period, the day of reconstruction increased significantly (from 6.12 days in 2002 to 12.50 days in 2011; coefficient, 0.09; 95 percent CI, 0.05 to 0.12; p < 0.001). Demographic and facility factors did not significantly impact timing. Elixhauser comorbidity scores greater than 2 were associated with later coverage (10.13 days versus 6.29 days; p = 0.001) along with multisite fractures (8.35 days; p = 0.022) and external fixators (8.78 days; p < 0.001). The U.S. Census division showed significant variation in timing ranging from 0.94 days (East North Central) to 9.84 days (Pacific).
   Conclusions: A progressive delay in the timing of soft-tissue reconstruction was noted and may be attributed to negative-pressure wound therapy. The timing of soft-tissue coverage varied by region after adjusting for patient and hospital factors. Additional studies are needed to understand the impact of delayed soft-tissue coverage on patient outcomes and health services utilization.
C1 Stanford Univ, Sch Med, Div Plast & Reconstruct Surg, Palo Alto, CA 94304 USA.
   Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA.
C3 Stanford University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Palo Alto Health Care System
RP Momeni, A (通讯作者)，Stanford Univ, Med Ctr, Div Plast & Reconstruct Surg, 770 Welch Rd,Suite 400, Palo Alto, CA 94304 USA.
EM amomeni@stanford.edu
RI Momeni, Arash/AAV-8300-2020
OI Momeni, Arash/0000-0002-6452-751X
CR Agency for Healthcare Research and Quality, HCUP DAT HEALTC COST
   [Anonymous], HCUP METH SER
   [Anonymous], 2010, Diffusion of Innovations
   Birkmeyer JD, 2013, LANCET, V382, P1121, DOI 10.1016/S0140-6736(13)61215-5
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NR 31
TC 7
Z9 9
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2018
VL 142
IS 5
BP 1337
EP 1347
DI 10.1097/PRS.0000000000004885
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GY1XO
UT WOS:000448330200080
PM 30511989
DA 2026-07-24
ER
PT J
AU Buckarma, ELN
   Rivera, M
   Schiller, H
   Loomis, E
AF Buckarma, Eee L. N.
   Rivera, Mariela
   Schiller, Henry
   Loomis, Erica
TI Outcomes After the Implementation of Practice Management Guidelines for
   the Treatment of Cardiovascular Implantable Device Pocket Infections
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Cardiovascular implantable device; Pocket infection; Wound care; Wound
   vacuum therapy
ID CARDIOVERTER-DEFIBRILLATORS; PACEMAKERS; LAPAROTOMY; CLOSURE
AB Background: Treatment of cardiovascular implantable device pocket infections (CIDPIs) requires a multimodal approach that includes antimicrobials, device explantation, and local wound care. Our institution implemented a practice management guideline (PMG) to standardize the care of CIDPIs and engage our acute care surgeons in 2013. Our PMG includes wound culture, complete capsulectomy, pulse lavage, and the placement of a negative pressure wound therapy appliance at the time of device extraction. Forty-eight hours later, wounds are irrigated and closed in a delayed primary fashion over drains. Our objective was to compare the outcomes of patients who underwent device extraction before and after the implementation of the PMG for the treatment of CIDPIs.
   Methods: An IRB-approved retrospective review of 155 patients at our institution from 2012 to 2015 who underwent device explantation. Evaluated outcomes measured included days from device explant to wound closure, and postoperative complications. Outcomes data were analyzed before (pre-PMG) and after (post-PMG) enactment of the PMG.
   Results: Fifty-eight patients (42 males; mean age 68 years) were managed prior to PMG implementation; 97 (72 males; mean age 67) were managed after. Mean days from device explantation to wound closure were compared (pre-PMG 6 +/- 3.5 and post-PMG 2.8 +/- 1.8), and time to closure was reduced by 3-d post-PMG implementation (P < 0.05). No increase in surgical site infection, hematoma, or unplanned return to operating room was demonstrated between groups (P < 0.05).
   Conclusions: The implementation of a PMG for the management of CIDPIs is effective in reducing the number of days to pocket wound closure; acute care surgeons are well equipped to participate in this practice and improve patient outcomes. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Buckarma, Eee L. N.; Rivera, Mariela; Schiller, Henry; Loomis, Erica] Mayo Clin, Dept Surg, 200 First St Southwest, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Buckarma, ELN (通讯作者)，Mayo Clin, Dept Surg, 200 First St Southwest, Rochester, MN 55905 USA.
EM Buckarma.EeeLN@mayo.edu
RI Rivera, Mariela/PGU-3948-2026
CR Agrawal V, 2017, INDIAN J SURG, V79, P124, DOI 10.1007/s12262-015-1438-x
   Anghel EL, 2016, PLAST RECONSTR SURG, V138, p82S, DOI 10.1097/PRS.0000000000002651
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NR 11
TC 1
Z9 1
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD DEC
PY 2018
VL 232
BP 643
EP 646
DI 10.1016/j.jss.2018.07.065
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GY1YP
UT WOS:000448333700089
PM 30463786
DA 2026-07-24
ER
PT J
AU Tang, XH
   Chen, C
   Liu, YD
   Qiao, XF
   Liu, H
   Ma, ZM
   Zhu, JM
   Liu, JJ
AF Tang, Xiao-Huan
   Chen, Chao
   Liu, Yuan-Da
   Qiao, Xiao-Fang
   Liu, Hao
   Ma, Zhi-Ming
   Zhu, Jia-Ming
   Liu, Jing-Jing
TI A rare postoperative complication of perforated appendicitis:
   necrotizing fasciitis
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Necrotizing fasciitis; perforated appendicitis; postoperative
   complication; lumbar triangles; vacuum sealing drainage
AB Perforated appendicitis is a type of acute appendicitis with a morbidity rate of 15.8%. In addition, potentially fatal postoperative complications associated with laparoscopic appendectomy for perforated appendicitis may occur with wound infections comprising 15.2% of such complications. Herein we report a case in which a 35-yearold woman presented with acute appendicitis in the clinic. After failure with conservative treatment, laparoscopic appendectomy was performed. Five days after the operation, the patient developed necrotizing fasciitis which was then treated with surgical debridement. After ten days of conservative treatment with intravenous antibiotics and forty days of modified vacuum sealing drainage, the patient attained full recovery. This case represents a potentially fatal postoperative complication of perforated appendicitis which is especially rare. Retroperitoneal inflammation and/or abscesses may cause necrotizing fasciitis through lumbar triangles, which are two weak areas in the loin. Therefore, modified vacuum sealing drainage is a simple and effective treatment to treat necrotizing fasciitis.
C1 [Tang, Xiao-Huan; Chen, Chao; Liu, Yuan-Da; Qiao, Xiao-Fang; Liu, Hao; Ma, Zhi-Ming; Zhu, Jia-Ming; Liu, Jing-Jing] Jilin Univ, Dept Gastrointestinal Nutr & Hernia Surg, Hosp 2, 218 Zigiang St, Changchun 130041, Jilin, Peoples R China.
C3 Jilin University
RP Zhu, JM; Liu, JJ (通讯作者)，Jilin Univ, Dept Gastrointestinal Nutr & Hernia Surg, Hosp 2, 218 Zigiang St, Changchun 130041, Jilin, Peoples R China.
EM Zhujiaming75@sina.com; jingjingstarone@163.com
RI Zhu, Jiaming/OJZ-8196-2025; Tang, xiaohuan/HGT-7031-2022
FU Research Fund of Health and Family Plan-ning Commission of Jilin
   Province [2016C0543]
FX We thank the Department of Imaging, the Second Hospital of Jilin
   University for the CT's pictures provided. This study was supported by
   the Research Fund of Health and Family Plan-ning Commission of Jilin
   Province (2016C0543). Informed consent was obtained from the patients in
   this study and approval for these studies was obtained through the
   institutional Ethics Committee.
CR Beerle Corinne, 2016, J Med Case Rep, V10, P331, DOI 10.1186/s13256-016-1122-1
   Drake FT, 2014, JAMA SURG, V149, P837, DOI 10.1001/jamasurg.2014.77
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   Liu ZF, 2015, INT J CLIN EXP MED, V8, P19626
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NR 14
TC 2
Z9 2
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 9
BP 10126
EP 10130
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GY8AL
UT WOS:000448839700158
DA 2026-07-24
ER
PT J
AU Bai, M
   Zhang, HL
   Long, F
   Yu, NZ
   Zeng, A
   Zhao, R
AF Bai, Ming
   Zhang, Hailin
   Long, Fei
   Yu, Nanze
   Zeng, Ang
   Zhao, Ru
TI Treatment of sternal osteomyelitis after open heart surgery with
   combined negative pressure wound therapy with rectus abdominis
   myocutaneous flap transfer: a case report
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Negative pressure suction wound therapy; osteomyelitis of sternum;
   debridement; wound repair; flap transplantation
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; PROLIFERATION; COMPLICATIONS
AB The effectiveness of combination of negative pressure wound therapy with rectus abdominis myocutaneous flap transfer in treating sternal osteomyelitis associated with open heart surgery is not clear. Here we reported a case. A 57 years old male with past medical history of Diabetes underwent coronary artery bypass grafting surgery (CABG) in our hospital. After CABG, the wound was infected and dehiscenced, postoperative osteomyelitis of sternum was diagnosed. There was no significant improvement in the wound condition after conservative treatment with topical antibiotics and dressing change for one week. Thus combinatory negative pressure wound therapy with rectus abdominis myocutaneous flap transfer was performed sequentially. Briefly, after thorough debridement and removal of sequestrum, continuous negative pressure wound therapy was applied; then phase II wound repair with rectus abdominis myocutaneous flap transfer was performed to heal the wound. The combined treatment was successful. After the treatment, clean wound and growth of fresh granulation were observed, and the rectus abdominis myocutaneous flap survived and the wound was found to heal well during postoperative follow ups. In conclusion, we found that combinatory application of negative pressure wound therapy with rectus abdominis myocutaneous flap transfer could effectively control wound infection, promote the shedding of necrotic tissue, and accelerate wound healing.
C1 Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Plast & Reconstruct Surg, Beijing, Peoples R China.
   Peking Union Med Coll, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College
RP Zhao, R (通讯作者)，Beijing Union Med Coll Hosp, Dept Plast & Reconstruct Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China.
EM Baiming2000@sina.com
RI /AAT-4908-2020
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NR 18
TC 0
Z9 0
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 10
BP 11349
EP 11354
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GY8BQ
UT WOS:000448844100140
DA 2026-07-24
ER
PT J
AU Miyahara, HD
   Serzedello, FR
   Ejnisman, L
   Lima, ALLM
   Vicente, JRN
   Helito, CP
AF Miyahara, Helder de Souza
   Serzedello, Felipe Ribeiro
   Ejnisman, Leandro
   Lei Munhoz Lima, Ana Lucia
   Negreiros Vicente, Jost Ricardo
   Helito, Camilo Partezani
TI INCISIONAL NEGATIVE-PRESSURE WOUND THERAPY IN REVISION TOTAL HIP
   ARTHROPLASTY DUE TO INFECTION
SO ACTA ORTOPEDICA BRASILEIRA
LA English
DT Article
DE Negative-pressure wound therapy; Arthroplasty; replacement; hip;
   Surgical wound dehiscence
ID SURGICAL SITE COMPLICATIONS; KNEE ARTHROPLASTY; DRESSINGS; SURGERY;
   SYSTEM
AB Objective: To present our institution's experience with negative-pressure wound therapy (NPWT) as an adjuvant in wound healing of patients who have undergone revision total hip arthroplasty (THA) due to septic loosening in the presence of active fistula. Methods: We prospectively assessed patients presenting with THA infection, associated with the presence of fistula, treated with a PICO (R) device for NPWT, in combination with the standard treatment for prosthesis infection in our institution. Resolution of the infectious process and healing of the surgical wound without complications were considered an initial favorable outcome. Results: We assessed 10 patients who used PICO (R) in our department. No complications were identified in association with the use of the NPWT device. The mean follow-up of the patients after use of the device was 12.7 months. Only one patient progressed with fistula reactivation and recurrence of infection. Conclusion: NPWT can be used in wound complications and infection following THA procedures safely and with promising results. Randomized prospective studies should be conducted to confirm its effectiveness.
C1 [Miyahara, Helder de Souza; Serzedello, Felipe Ribeiro; Ejnisman, Leandro; Negreiros Vicente, Jost Ricardo] Univ Sao Paulo, Fac Med, Inst Ortopedia & Traumatol, Hosp Clin HCFMUSP,Hip Grp, Sao Paulo, SP, Brazil.
   [Lei Munhoz Lima, Ana Lucia] Univ Sao Paulo, Fac Med, Inst Ortopedia & Traumatol, Hosp Clin HCFMUSP,Hosp Infect Comm, Sao Paulo, SP, Brazil.
   [Helito, Camilo Partezani] Univ Sao Paulo, Fac Med, Inst Ortopedia & Traumatol, Hosp Clin HCFMUSP,Knee Grp, Sao Paulo, SP, Brazil.
   [Helito, Camilo Partezani] Hosp Sirio Libanes, Sao Paulo, Brazil.
   [Miyahara, Helder de Souza; Serzedello, Felipe Ribeiro; Ejnisman, Leandro; Lei Munhoz Lima, Ana Lucia; Negreiros Vicente, Jost Ricardo; Helito, Camilo Partezani] Univ Sao Paulo, Fac Med, Dept Orthoped & Traumatol, Lab Invest Med Sistema Musculoesquelet,Hip Surg D, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Hospital Sirio Libanes; Universidade de Sao Paulo
RP Miyahara, HD (通讯作者)，Rua Dr Ovidio Pires de Campos 333, BR-05403010 Sao Paulo, SP, Brazil.
EM helder_miyahara@hotmail.com
RI ; Partezani Helito, Camilo/X-3880-2019; Lima, Ana Lucia
   Munhoz/L-7898-2017; Ejnisman, Leano/HTP-2565-2023
OI Miyahara, Helder/0000-0002-2532-2685; Partezani Helito,
   Camilo/0000-0003-1139-2524; Lima, Ana Lucia Munhoz/0000-0002-2396-9880;
   Ejnisman, Leano/0000-0002-9866-1960
CR Almustafa MA, 2018, J ARTHROPLASTY, V33, P1855, DOI 10.1016/j.arth.2018.01.037
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   Cooper HJ, 2016, J ARTHROPLASTY, V31, P1047, DOI 10.1016/j.arth.2015.11.010
   DeCarbo WT, 2010, J FOOT ANKLE SURG, V49, P299, DOI 10.1053/j.jfas.2010.01.002
   Ene Razvan, 2015, Maedica (Bucur), V10, P5
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   Matsumoto T, 2015, FOOT ANKLE INT, V36, P787, DOI 10.1177/1071100715574934
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   Payne Caroline, 2014, Eplasty, V14, pe20
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NR 20
TC 6
Z9 8
U1 0
U2 3
PU ATHA COMUNICACAO & EDITORA
PI SAO PAULO SP
PA RUA MACHADO BITTENCOURT, 190-40 ANDAR, CONJ 410, SAO PAULO SP, 00000,
   BRAZIL
SN 1413-7852
EI 1809-4406
J9 ACTA ORTOP BRAS
JI Acta Ortop. Bras.
PD SEP-OCT
PY 2018
VL 26
IS 5
BP 300
EP 304
DI 10.1590/1413-785220182605196038
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA GY9QQ
UT WOS:000448984100004
PM 30464709
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, ZM
   Dumville, JC
   Hinchliffe, RJ
   Cullum, N
   Game, F
   Stubbs, N
   Sweeting, M
   Peinemann, F
AF Liu, Zhenmi
   Dumville, Jo C.
   Hinchliffe, Robert J.
   Cullum, Nicky
   Game, Fran
   Stubbs, Nikki
   Sweeting, Michael
   Peinemann, Frank
TI Negative pressure wound therapy for treating foot wounds in people with
   diabetes mellitus
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Amputation; Bandages; Wound Healing; Debridement; Diabetic Foot
   [surgery]; Negative-Pressure Wound Therapy [adverse effects; methods];
   Randomized Controlled Trials as Topic; Humans
ID VACUUM-ASSISTED-CLOSURE; QUALITY-OF-LIFE; CALCIUM ALGINATE DRESSINGS;
   CLASSIFICATION-SYSTEM; ULCERS; MANAGEMENT; AMPUTATION; MOIST;
   MULTICENTER; TRIAL
AB Background
   Foot wounds in people with diabetes mellitus (DM) are a common and serious global health issue. People with DM are prone to developing foot ulcers and, if these do not heal, they may also undergo foot amputation surgery resulting in postoperative wounds. Negative pressure wound therapy (NPWT) is a technology that is currently used widely in wound care. NPWT involves the application of a wound dressing attached to a vacuum suction machine. A carefully controlled negative pressure (or vacuum) sucks wound and tissue fluid away from the treated area into a canister. A clear and current overview of current evidence is required to facilitate decision making regarding its use.
   Objectives
   To assess the effects of negative pressure wound therapy compared with standard care or other therapies in the treatment of foot wounds in people with DM in any care setting.
   Search methods
   In January 2018, for this first update of this review, we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE (including In-Process & Other Non-Indexed Citations); Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries for ongoing and unpublished studies, and scanned reference lists of relevant included studies, reviews, meta-analyses and health technology reports to identify additional studies. There were no restrictions with respect to language, date of publication or study setting. We identified six additional studies for inclusion in the review.
   Selection criteria
   Published or unpublished randomised controlled trials (RCTs) that evaluated the effects of any brand of NPWT in the treatment of foot wounds in people with DM, irrespective of date or language of publication. Particular effort was made to identify unpublished studies.
   Data collection and analysis
   Two review authors independently performed study selection, risk of bias assessment and data extraction. Initial disagreements were resolved by discussion, or by including a third review author when necessary. We presented and analysed data separately for foot ulcers and postoperative wounds.
   Main results
   Eleven RCTs (972 participants) met the inclusion criteria. Study sample sizes ranged from 15 to 341 participants. One study had three arms, which were all included in the review. The remaining 10 studies had two arms. Two studies focused on postamputation wounds and all other studies included foot ulcers in people with DM. Ten studies compared NPWT with dressings; and one study compared NPWT delivered at 75 mmHg with NPWT delivered at 125 mmHg. Our primary outcome measures were the number of wounds healed and time to wound healing.
   NPWT compared with dressings for postoperative wounds
   Two studies (292 participants) compared NPWT with moist wound dressings in postoperative wounds (postamputation wounds). Only one study specified a follow-up time, which was 16 weeks. This study (162 participants) reported an increased number of healed wounds in the NPWT group compared with the dressings group (risk ratio (RR) 1.44, 95% confidence interval (CI) 1.03 to 2.01; low-certainty evidence, downgraded for risk of bias and imprecision). This study also reported that median time to healing was 21 days shorter with NPWT compared with moist dressings (hazard ratio (HR) calculated by review authors 1.91, 95% CI 1.21 to 2.99; low-certainty evidence, downgraded for risk of bias and imprecision). Data from the two studies suggest that it is uncertain whether there is a difference between groups in amputation risk (RR 0.38, 95% CI 0.14 to 1.02; 292 participants; very low-certainty evidence, downgraded once for risk of bias and twice for imprecision).
   NPWT compared with dressings for foot ulcers
   There were eight studies (640 participants) in this analysis and follow-up times varied between studies. Six studies (513 participants) reported the proportion of wounds healed and data could be pooled for five studies. Pooled data (486 participants) suggest that NPWT may increase the number of healed wounds compared with dressings (RR 1.40, 95% CI 1.14 to 1.72; I-2 = 0%; low-certainty evidence, downgraded once for risk of bias and once for imprecision). Three studies assessed time to healing, but only one study reported usable data. This study reported that NPWT reduced the time to healing compared with dressings (hazard ratio (HR) calculated by review authors 1.82, 95% CI 1.27 to 2.60; 341 participants; low-certainty evidence, downgraded once for risk of bias and once for imprecision).
   Data from three studies (441 participants) suggest that people allocated to NPWT may be at reduced risk of amputation compared with people allocated to dressings (RR 0.33, 95% CI 0.15 to 0.70; I-2 = 0%; low-certainty evidence; downgraded once for risk of bias and once for imprecision).
   Low-pressure compared with high-pressure NPWT for foot ulcers
   One study (40 participants) compared NPWT 75 mmHg and NPWT 125 mmHg. Follow-up time was four weeks. There were no data on primary outcomes. There was no clear difference in the number of wounds closed or covered with surgery between groups (RR 0.83, 95% CI 0.47 to 1.47; very low-certainty evidence, downgraded once for risk of bias and twice for serious imprecision) and adverse events (RR 1.50, 95% CI 0.28 to 8.04; very low-certainty evidence, downgraded once for risk of bias and twice for serious imprecision).
   Authors' conclusions
   There is low-certainty evidence to suggest that NPWT, when compared with wound dressings, may increase the proportion of wounds healed and reduce the time to healing for postoperative foot wounds and ulcers of the foot in people with DM. For the comparisons of different pressures of NPWT for treating foot ulcers in people with DM, it is uncertain whether there is a difference in the number of wounds closed or covered with surgery, and adverse events. None of the included studies provided evidence on time to closure or coverage surgery, health-related quality of life or cost-effectiveness. The limitations in current RCT evidence suggest that further trials are required to reduce uncertainty around decision-making regarding the use of NPWT to treat foot wounds in people with DM.
C1 [Liu, Zhenmi] Sichuan Univ, West China Hosp, West China Sch Publ Hlth, Chengdu 610041, Sichuan, Peoples R China.
   [Liu, Zhenmi; Dumville, Jo C.; Cullum, Nicky] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
   [Hinchliffe, Robert J.] St Georges Healthcare NHS Trust, St Georges Vasc Inst, London, England.
   [Game, Fran] Derby Hosp NHS Fdn Trust, Dept Diabet & Endocrinol, Derby, England.
   [Stubbs, Nikki] Leeds Community Healthcare NHS Trust, St Marys Hosp, Leeds, W Yorkshire, England.
   [Sweeting, Michael] Univ Leicester, Coll Life Sci, Dept Hlth Sci, Leicester, Leics, England.
   [Peinemann, Frank] Univ Cologne, Childrens Hosp, Pediat Oncol & Hematol, Cologne, Germany.
C3 Sichuan University; University of Manchester; City St Georges,
   University of London; University of Leicester; University of Cologne
RP Liu, ZM (通讯作者)，Sichuan Univ, West China Hosp, West China Sch Publ Hlth, Chengdu 610041, Sichuan, Peoples R China.
EM zhenmiliu@scu.edu.cn
RI ; Sweeting, Michael/U-3917-2019; Liu, Zhenmi/O-7046-2014; Cullum,
   Nicky/F-2438-2011; Dumville, Jo/O-7867-2014; /H-2800-2019
OI Hinchliffe, Robert/0000-0002-6370-0800; Sweeting,
   Michael/0000-0003-0980-8965; Game, Frances/0000-0002-5294-4789
FU Division of Nursing, Midwifery and Social Work, School of Health
   Sciences, Faculty of Biology, Medicine and Health, University of
   Manchester, UK, UK; National Institute for Health Research (NIHR), UK;
   NIHR, via Cochrane Infrastructure and Cochrane Programme Grant (NIHR
   Cochrane Programme) [13/89/08]; NIHR Manchester Biomedical Research
   Centre (BRC), UK; National Institute for Health Research Collaboration
   for Leadership in Applied Health Research and Care (NIHR CLAHRC),
   Greater Manchester, UK; National Institute for Health Research (NIHR)
   Systematic Review Fellowships, UK [NIHR-RMFI-2015-06-52]; NIHR
   Manchester BRC; NIHR CLAHRC, Greater Manchester; National Institute for
   Health Research [13/89/08, NF-SI-0512-10028] Funding Source:
   researchfish
FX Internal sources Division of Nursing, Midwifery and Social Work, School
   of Health Sciences, Faculty of Biology, Medicine and Health, University
   of Manchester, UK, UK. External sources National Institute for Health
   Research (NIHR), UK. This project was supported by the NIHR, via
   Cochrane Infrastructure and Cochrane Programme Grant funding (NIHR
   Cochrane Programme Grant 13/89/08 - High Priority Cochrane Reviews in
   Wound Prevention and Treatment) to Cochrane Wounds. The views and
   opinions expressed herein are those of the authors and do not
   necessarily reflect those of the Systematic Reviews Programme, the NIHR,
   the NHS or the Department of Health. NIHR Manchester Biomedical Research
   Centre (BRC), UK. This research was co-funded by the NIHR Manchester
   BRC. The views expressed in this publication are those of the authors
   and not necessarily those of the NHS, the National Institute for Health
   Research or the Department of Health. National Institute for Health
   Research Collaboration for Leadership in Applied Health Research and
   Care (NIHR CLAHRC), Greater Manchester, UK. Nicky Cullum and Jo
   Dumville's work on this project was partly funded by the NIHR CLAHRC,
   Greater Manchester. The funder had no role in the decision to publish,
   or preparation of the manuscript. However, the review may be considered
   to be affiliated to the work of the NIHR CLAHRC Greater Manchester. The
   views expressed herein are those of the authors and not necessarily
   those of the NHS, NIHR or the Department of Health. National Institute
   for Health Research (NIHR) Systematic Review Fellowships
   (NIHR-RMFI-2015-06-52 Zhenmi Liu), UK.
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NR 114
TC 140
Z9 169
U1 1
U2 71
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2018
IS 10
AR CD010318
DI 10.1002/14651858.CD010318.pub3
PG 84
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GZ0JU
UT WOS:000449049600046
PM 30328611
OA Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Hodson, T
   West, JM
   Poteet, SJ
   Lee, PH
   Valerio, IL
AF Hodson, Trevor
   West, Julie M.
   Poteet, Stephen J.
   Lee, Peter H.
   Valerio, Ian L.
TI Instillation Negative Pressure Wound Therapy: A Role for Infected LVAD
   Salvage
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure; VAC with instillation; debridement; infection
ID PERIPROSTHETIC HIP; MANAGEMENT; SURGERY
AB Objective: To determine the utility of instillation negative pressure wound therapy (NPWT) in achieving eradication of infection and definitive wound closure in patients with infected left ventricular assist device (LVAD).
   Approach: A retrospective review was performed in a series of patients with infected and exposed LVADs who were treated with instillation NPWT in conjunction with surgical debridement.
   Results: Three consecutive patients were included who developed periprosthetic infection subsequent to LVAD implantation. In all cases, the utilization of a vacuum-assisted closure with instillation (VACi) along with surgical debridement and IV antibiotics eradicated infection resulting in successful retention of hardware. Cases 1 and 2 received definitive wound closure within 3 and 12 days of starting treatment, respectively. Case 3 initially deferred surgery in favor of local wound care. Eventually the patient elected for surgical treatment and underwent closure 164 days after initial presentation. All three patients healed completely without residual evidence of infection. Flap reconstruction with a pedicled rectus flap was used to achieve definitive closure in all patients. One patient subsequently required pump replacement secondary to thrombosis and mechanical pump failure.
   Innovation: LVAD infections are met with high morbidity and mortality rates, and timely salvage is critical. In this initial series, VACi has proven a viable therapy option to help control and eradicate infection without LVAD removal.
   Conclusion: This series illustrates the value of newer techniques such as VACi in combination with surgical debridement and antibiotic therapy in effectively salvaging LVADs that were infected.
C1 [Hodson, Trevor; West, Julie M.; Poteet, Stephen J.; Valerio, Ian L.] Ohio State Univ, Wexner Med Ctr, Dept Plast Surg, 915 Olentangy River Rd,Ste 2100, Columbus, OH 43212 USA.
   [Lee, Peter H.] Ohio State Univ, Wexner Med Ctr, Div Cardiac Surg, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Valerio, IL (通讯作者)，Ohio State Univ, Wexner Med Ctr, Dept Plast Surg, 915 Olentangy River Rd,Ste 2100, Columbus, OH 43212 USA.
EM ian.valerio@osumc.edu
RI Valerio, Ian/F-9161-2017
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NR 22
TC 11
Z9 12
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAR 1
PY 2019
VL 8
IS 3
BP 118
EP 124
DI 10.1089/wound.2018.0832
EA NOV 2018
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HU5DH
UT WOS:000449369000001
PM 31737410
DA 2026-07-24
ER
PT J
AU Nikolic, H
   Versic, AB
   Cepic, I
   Hasandic, D
   Medancic, SS
   Miletic, D
   Tadin, T
   Persic, M
AF Nikolic, Harry
   Versic, Ana Bosak
   Cepic, Ivica
   Hasandic, Damir
   Medancic, Suzana Srsen
   Miletic, Damir
   Tadin, Tomislav
   Persic, Mladen
TI Psoas abscess as the first manifestation of Crohn's disease - case
   report
SO SIGNA VITAE
LA English
DT Article
DE child; Crohn's disease; psoas abscess
ID ILIOPSOAS ABSCESS; DIAGNOSIS
AB A case of 16-year-old female with secondary psoas abscess as the complication of the Crohn's disease was analysed. Her pre-hospital, long lasting, non-specific symptoms led to ultrasound (US) and radiologic imaging confirming the diagnosis. The antibiotic treatment was insufficient and worsening of the patient's condition required surgical treatment including descendent colectomy, abscess drainage and negative pressure wound therapy (NPWT). In spite of numerous complications the condition of the child gradually unproved and she was discharged from the hospital on the 71st postoperative day. Two years after the colectomy, the occlusion of her colostomy was performed.
C1 [Nikolic, Harry; Versic, Ana Bosak; Hasandic, Damir; Medancic, Suzana Srsen] Univ Hosp Rijeka, Pediat Surg Dept, Rijeka, Croatia.
   [Cepic, Ivica] Univ Hosp Rijeka, Gen Surg Dept, Rijeka, Croatia.
   [Miletic, Damir] Univ Hosp Rijeka, Dept Radiol, Rijeka, Croatia.
   [Tadin, Tomislav] Hlth Ctr Rijeka, Ultrasound Diagnost Serv, Rijeka, Croatia.
   [Persic, Mladen] Univ Hosp Rijeka, Pediat Dept, Rijeka, Croatia.
C3 University of Rijeka; University of Rijeka; University of Rijeka;
   University of Rijeka
RP Tadin, T (通讯作者)，Ultrasound Diagnost Serv, Martina Kontusa 18, Rijeka 51000, Croatia.
EM medicina_ri@inet.hr
RI Miletic, Damir/R-5132-2018
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NR 10
TC 1
Z9 1
U1 0
U2 3
PU PHARMAMED MADO LTD
PI ZAGREB
PA ZATISJE 8 G, ZAGREB, 10000, CROATIA
SN 1334-5605
J9 SIGNA VITAE
JI Signa Vitae
PY 2018
VL 14
IS 2
BP 78
EP 79
DI 10.22514/SV142.112018.13
PG 2
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA GZ5KV
UT WOS:000449460400013
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Ludolph, I
   Fried, FW
   Kneppe, K
   Arkudas, A
   Schmitz, M
   Horch, RE
AF Ludolph, Ingo
   Fried, Frederik W.
   Kneppe, Katharina
   Arkudas, Andreas
   Schmitz, Marweh
   Horch, Raymund E.
TI Negative pressure wound treatment with computer-controlled
   irrigation/instillation decreases bacterial load in contaminated wounds
   and facilitates wound closure
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bacterial load; contaminated wounds; instillation; negative pressure
   wound therapy
ID VACUUM-ASSISTED CLOSURE; THERAPY; INSTILLATION; RECOMMENDATIONS;
   PROLOGUE; SALVAGE
AB Microbial wound contamination is known to be a hindrance to wound healing. Negative pressure wound therapy (NPWT) with or without irrigation is known to optimise conditions in problem wounds. The aim of this study was to investigate the influence of computer-controlled wound irrigation with NPWT on the bacterial load in contaminated wounds. A total of 267 patients were treated with NPWT with automated instillation because of problematic wounds using an antiseptic instillation solution. In 111 patients, a minimum of 4 operative procedures were necessary, and swabs were taken at least at the first and at the fourth operation in a standardised procedure. The number of different bacteria and the amount of bacteria were analysed during the course. In a subgroup of 51 patients, swabs were taken at all 4 operative procedures and analysed separately. In an overall analysis, the number of different bacteria and the amount of bacteria significantly decreased independent of wound localisation and diagnosis. NPWT with automated instillation demonstrates a positive influence in the reduction of bacterial load in problem wounds. Thus, it may help to optimise wound conditions before definite wound closure.
C1 Friedrich Alexander Univ Erlangen Nuernberg FAU, Univ Hosp Erlangen, Dept Plast & Hand Surg, Erlangen, Germany.
   Friedrich Alexander Univ Erlangen Nuernberg FAU, Univ Hosp Erlangen, Lab Tissue Engn & Regenerat Med, Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Ludolph, I (通讯作者)，Krankenhausstr 12, D-91054 Erlangen, Germany.
EM ingo.ludolph@uk-erlangen.de
RI Horch, Raymund/H-8128-2019; Arkudas, Andreas/AAQ-6745-2021
OI Arkudas, Andreas/0000-0002-2473-5816
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NR 33
TC 45
Z9 55
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2018
VL 15
IS 6
BP 978
EP 984
DI 10.1111/iwj.12958
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GZ7ES
UT WOS:000449641000016
PM 29974664
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Virgilio, E
   Ceci, D
   Cavallini, M
AF Virgilio, Edoardo
   Ceci, Diego
   Cavallini, Marco
TI Surgical Endoscopic Vacuum-assisted Closure Therapy (EVAC) in Treating
   Anastomotic Leakages After Major Resective Surgery of Esophageal and
   Gastric Cancer
SO ANTICANCER RESEARCH
LA English
DT Review
DE Endoscopic vacuum therapy; endoscopic vacuum-assisted closure system;
   EVAC; endoscopic negative pressure therapy; ENPT; intraluminal;
   intracavitary; negative pressure wound therapy; NPWT; anastomotic
   leakage; nasogastric tube; mediastinitis; intrathoracic abscess; review
ID UPPER GASTROINTESTINAL-TRACT; TUMOR-MARKERS; LEAKS; LAVAGE; MANAGEMENT;
   OPTIONS; STENT; CELLS; PERFORATION; CARCINOMA
AB Background/Aim: Endoscopic vacuum-assisted closure therapy (EVAC) is a promising new technique for repairing upper gastrointestinal defects of different etiologies. As of 2018, however, no standardized recommendation exists. This article reviewed EVAC in treating anastomotic leakage following major resective surgery of esophageal (EC) and gastric cancer (GC). Materials and Methods: Only English-language literature was investigated. Only studies or data on EC and GC were included. Seven popular search engines (PubMed, Web of Science, ScienceDirect, Scopus, Google Scholar, ResearchGate, PubFacts) were utilized. Results: A total of 29 studies (17 retrospective, six prospective and six case reports) with a total of 209 patients. Range of anastomotic leakage closure was 66.7-100%. Anastomotic stricture was the most frequent long-term related complication (18 cases). Conclusion: EVAC appears to be an extremely useful treatment for postsurgical anastomotic leakage in patients with EC/GC. Almost all kinds of anastomotic leakage (silent to symptomatic, small to large) seem to be amenable to this technique.
C1 [Virgilio, Edoardo; Ceci, Diego; Cavallini, Marco] Sapienza Univ, St Andrea Hosp, Fac Med & Psychol, Dept Med & Surg Sci & Translat Med, Rome, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea
RP Virgilio, E (通讯作者)，Univ Sapienza, St Andrea Hosp, Dept Med & Surg Sci & Translat Med, Div Gen Surg,Fac Med & Psychol, Via Grottarossa 1035-39, I-00189 Rome, Italy.
EM aresedo1992@yahoo.it
RI VIRGILIO, EDOARDO/B-4965-2015
OI VIRGILIO, EDOARDO/0000-0002-9324-3487
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   Wallstabe I, 2010, ENDOSCOPY, V42, pE165, DOI 10.1055/s-0029-1244150
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   Weidenhagen R, 2010, ANN THORAC SURG, V90, P1674, DOI 10.1016/j.athoracsur.2010.07.007
   Youn HC, 2016, ANN THORAC CARDIOVAS, V22, P363, DOI 10.5761/atcs.cr.15-00305
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NR 51
TC 45
Z9 55
U1 0
U2 4
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0250-7005
EI 1791-7530
J9 ANTICANCER RES
JI Anticancer Res.
PD OCT
PY 2018
VL 38
IS 10
BP 5581
EP 5587
DI 10.21873/anticanres.12892
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA HA1IK
UT WOS:000449965500002
PM 30275175
OA Bronze
DA 2026-07-24
ER
PT J
AU Gatti, G
   Ledwon, M
   Gazdag, L
   Cuomo, F
   Pappalardo, A
   Fischlein, T
   Santarpino, G
AF Gatti, Giuseppe
   Ledwon, Miroslaw
   Gazdag, Laszlo
   Cuomo, Federica
   Pappalardo, Aniello
   Fischlein, Theodor
   Santarpino, Giuseppe
TI Management of closed sternal incision after bilateral internal thoracic
   artery grafting with a single-use negative pressure system
SO UPDATES IN SURGERY
LA English
DT Article
DE Arterial grafts; Coronary artery bypass grafting; Prevention; Quality of
   care improvement; Sternal wound infection
ID PREDICTIVE SCORING SYSTEM; WOUND THERAPY; CARDIAC-SURGERY; INFECTION;
   PERFUSION; RISK; VALIDATION; TRIAL
AB Single-use, closed incision management (CIM) systems offer a practical means of delivering negative pressure wound therapy to patients. This prospective study evaluates the Prevena Therapy system in a cohort of coronary patients at high risk of deep sternal wound infection (DSWI). Fifty-three consecutive patients undergoing bilateral internal thoracic artery (BITA) grafting were preoperatively elected for CIM with the Prevena Therapy system, which was applied immediately after surgery. The actual rate of DSWI in these patients was compared with the expected risk of DSWI according to two scoring systems specifically created to predict either DSWI after BITA grafting (Gatti score) or major infections after cardiac surgery (Fowler score). The actual rate of DSWI was lower than the expected risk of DSWI by the Gatti score (3.8 vs. 5.8%, p=0.047) but higher than by the Fowler score (2.3%, p=0.069). However, while the Gatti score showed very good calibration ((2)=4.8, p=0.69) and discriminatory power (area under the receiver-operating characteristic curve 0.838), the Fowler score showed discrete calibration ((2)=10.5, p=0.23) and low discriminatory power (area under the receiver-operating characteristic curve 0.608). Single-use CIM systems appear to be useful to reduce the risk of DSWI after BITA grafting. More studies have to be performed to make stronger this finding.
C1 [Gatti, Giuseppe; Pappalardo, Aniello] Univ Hosp Trieste, Cardiothorac & Vasc Dept, Trieste, Italy.
   [Ledwon, Miroslaw; Gazdag, Laszlo; Cuomo, Federica; Fischlein, Theodor; Santarpino, Giuseppe] Paracelsus Med Univ, Klinikum Nurnberg, Cardiovasc Ctr, Dept Cardiac Surg, Nurnberg, Germany.
   [Santarpino, Giuseppe] Citta Lecce Hosp, GVM Care & Res, Dept Cardiac Surg, Lecce, Italy.
   [Gatti, Giuseppe] Osped Cattinara, Div Cardiac Surg, Via P Valdoni 7, I-34148 Trieste, Italy.
C3 University of Trieste; University Trieste Hospital; Klinikum Nurnberg
RP Gatti, G (通讯作者)，Univ Hosp Trieste, Cardiothorac & Vasc Dept, Trieste, Italy.; Gatti, G (通讯作者)，Osped Cattinara, Div Cardiac Surg, Via P Valdoni 7, I-34148 Trieste, Italy.
EM gius.gatti@gmail.com
RI Gatti, Giuseppe/A-3849-2017; Santarpino, Giuseppe/H-8678-2013
OI Gatti, Giuseppe/0000-0002-9996-6133; Santarpino,
   Giuseppe/0000-0002-4913-9834
CR [Anonymous], 2012, EUR J CARDIOTHORACIC
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NR 22
TC 9
Z9 11
U1 0
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD DEC
PY 2018
VL 70
IS 4
BP 545
EP 552
DI 10.1007/s13304-018-0515-7
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HA5GZ
UT WOS:000450299500017
PM 29460174
DA 2026-07-24
ER
PT J
AU Schniewind, B
   Schafmayer, C
   von Schönfels, W
   Heits, NG
   Kucharzik, T
   Klein, G
   Hampe, J
AF Schniewind, Bodo
   Schafmayer, Clemens
   von Schoenfels, Witigo
   Heits, Nils G.
   Kucharzik, Torsten
   Klein, Georg
   Hampe, Jochen
TI Treatment of Complicated Anal Fistula by an Endofistular
   Polyurethane-Sponge Vacuum Therapy: A Pilot Study
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE Anal fistula; Crohn's disease; Cryptoglandular fistula; Endoluminal
   polyurethane sponge; Endoluminal vacuum therapy; Negative pressure wound
   therapy
ID IN-ANO; CROHNS; MANAGEMENT; SURGERY; LEAKAGE
AB BACKGROUND: Treatment of supra- and transsphincteric anal fistulas remains a clinical challenge because current treatment results are variable and potentially endanger sphincter function.
   OBJECTIVE: Based on positive results of endoluminal polyurethane-sponge vacuum therapy in the upper and lower GI tract, a new system for endofistular vacuum therapy was developed for anal fistulas to utilize vacuum therapy to remove the endofistular pseudoepithelium and to induce granulation in the fistula tract.
   DESIGN: This study is based on a prospective case series.
   PATIENTS: Seven patients with complicated anal fistulas (3 associated with Crohn's disease and 4 of cryptoglandular origin) longer than 4cm were treated. Initially, the fistula was curettaged and the first endofistular vacuum therapy sponge was positioned in the fistula tract. The inner fistula opening was closed by suture. A 125mm Hg constant vacuum was applied to the sponge, and the endofistular vacuum therapy sponge was changed a median of 3 (3-5) times after each 48 to 72 hours of constant vacuum therapy. After final removal, the fistulas were reevaluated every other week for 3 months.
   MAIN OUTCOME MEASURE: The main outcome measured was the closure of the fistula.
   RESULTS: All patients tolerated the therapy well and no adverse events were observed. Fistula tract closure was demonstrated within 4 weeks after the termination of vacuum therapy. One patient with cryptoglandular fistula developed a recurrence within the follow-up of 3 months.
   LIMITATIONS: This was an observational study that had no control arm.
   CONCLUSION: In this pilot case series, the results are encouraging. Because endoluminal vacuum therapy would be a new and sphincter-sparing therapy, this concept warrants further investigation in controlled trials.
C1 [Schniewind, Bodo; Klein, Georg] Staedt Krankenhaus, Community Hosp Lueneburg, Dept Gen Visceral & Thorac Surg, Luneburg, Germany.
   [Schafmayer, Clemens; von Schoenfels, Witigo; Heits, Nils G.] Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Visceral & Thorac Surg, Kiel Campus, Kiel, Germany.
   [Schafmayer, Clemens; Kucharzik, Torsten] Staedt Krankenhaus, Community Hosp Lueneburg, Dept Internal Med, Luneburg, Germany.
   [Hampe, Jochen] Tech Univ Dresden, TU Dresden, Univ Hosp Dresden, Med Dept 1, Dresden, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; Technische
   Universitat Dresden; Carl Gustav Carus University Hospital
RP Schniewind, B (通讯作者)，Staedt Klinikum Lueneburg, Dept Gen Visceral & Thorac Surg, Boegelstr 1, D-21339 Luneburg, Germany.
EM Bodo.Schniewind@klinikum-lueneburg.de
RI /AAL-9780-2020; Hampe, Jochen/A-2555-2010
OI Hampe, Jochen/0000-0002-2421-6127
FU Medical faculty of the University Hospital Schleswig-Holstein/Germany
FX This research was supported by institutional funds from the Medical
   faculty of the University Hospital Schleswig-Holstein/Germany.
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NR 19
TC 2
Z9 4
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD DEC
PY 2018
VL 61
IS 12
BP 1435
EP 1441
DI 10.1097/DCR.0000000000001233
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA HA7AC
UT WOS:000450432100018
PM 30399049
DA 2026-07-24
ER
PT J
AU Curley, AJ
   Terhune, EB
   Velott, AT
   Argintar, EH
AF Curley, Andrew J.
   Terhune, Elizabeth B.
   Velott, Anthony T.
   Argintar, Evan H.
TI Outcomes of Prophylactic Negative Pressure Wound Therapy in Knee
   Arthroplasty
SO ORTHOPEDICS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EXPERIENCE; HIP; INFECTION; DRESSINGS;
   DRAINAGE
AB Negative pressure wound therapy is becoming more commonly used to prevent wound complications in joint arthroplasty, although few studies have assessed its outcomes compared with those of a traditional dry sterile dressing. This retrospective study assessed complications that required return to the operating room in a cohort of patients who received a dry sterile dressing (n=159) vs negative pressure wound therapy (n=32). There were significantly more overall complications (P=.0293) in the dry sterile dressing group (23.3%) compared with the negative pressure wound therapy group (6.3%); however, these findings were not statistically significant when each individual complication was compared separately. The infection rate in the dry sterile dressing group and the negative pressure wound therapy group was 5.7% and 0%, respectively (P=.3607). A larger, prospective study is needed to confirm the lower infection rate and before any definitive conclusions can be reached.
C1 [Curley, Andrew J.; Velott, Anthony T.] Medstar Georgetown Univ Hosp, Dept Orthoped, 3800 Reservoir Rd, Washington, DC 20007 USA.
   [Terhune, Elizabeth B.] Georgetown Univ, Sch Med, Washington, DC USA.
   [Argintar, Evan H.] Medstar Washington Hosp Ctr, Dept Orthoped, Washington, DC USA.
C3 Georgetown University; Georgetown University; MedStar Washington
   Hospital Center
RP Curley, AJ (通讯作者)，Medstar Georgetown Univ Hosp, Dept Orthoped, 3800 Reservoir Rd, Washington, DC 20007 USA.
EM AndrewJCurley@gmail.com
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   Manoharan V, 2016, J ARTHROPLASTY, V31, P2487, DOI 10.1016/j.arth.2016.04.016
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NR 13
TC 11
Z9 12
U1 0
U2 3
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD NOV-DEC
PY 2018
VL 41
IS 6
BP E837
EP E840
DI 10.3928/01477447-20181010-02
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HA8AF
UT WOS:000450508700016
PM 30321445
DA 2026-07-24
ER
PT J
AU Sahebally, SM
   McKevitt, K
   Stephens, I
   Fitzpatrick, F
   Deasy, J
   Burke, JP
   McNamara, D
AF Sahebally, Shaheel Mohammad
   McKevitt, Kevin
   Stephens, Ian
   Fitzpatrick, Fidelma
   Deasy, Joseph
   Burke, John Patrick
   McNamara, Deborah
TI Negative Pressure Wound Therapy for Closed Laparotomy Incisions in
   General and Colorectal Surgery A Systematic Review and Meta-analysis
SO JAMA SURGERY
LA English
DT Review
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   MANAGEMENT-SYSTEM; CLINICAL-TRIALS; PREVENTION; HERNIA; IMPACT; WALL
AB IMPORTANCE Surgical site infections (SSls) are common after laparotomy wounds and are associated with a significant economic burden. The use of negative pressure wound therapy (NPWT) has recently been broadened to closed surgical incisions.
   OBJECTIVE To evaluate the association of prophylactic NPWT with SSI rates in closed laparotomy incisions performed for general and colorectal surgery in elective and emergency settings.
   DATA SOURCES The PubMed, Embase, Cochrane Central Register of Controlled Trials, and Google Scholar databases were searched without language restrictions for relevant articles from inception until December 2017. The latest search was performed on December 31, 2017. The bibliographies of retrieved studies were further screened for potential additional studies.
   STUDY SELECTION Randomized clinical trials and nonrandomized studies were included. Unpublished reports were excluded, as were studies that examined NPWT (or standard nonpressure) dressings only without a comparator group. Studies that evaluated the use of NPWT in open abdominal incisions were also excluded. Disagreement was resolved by discussion, and if the question remained unsettled, the opinion of the senior author was sought. A total of 198 citations were identified, and 189 were excluded.
   DATA EXTRACTION AND SYNTHESIS This meta-analysis was conducted according to PRISMA guidelines. Data were independently extracted by 2 authors. A random-effects model was used for statistical analysis.
   MAIN OUTCOMES AND MEASURES The primary outcome measure was SSI, and secondary outcomes included seroma and wound dehiscence rates. These outcomes were chosen before data collection.
   RESULTS Nine unique studies (3 randomized trials and 2 prospective and 4 retrospective studies) capturing 1266 unique patients were included. Of these, 1187 patients with 1189 incisions were included in the final analysis (52.3% male among 7 studies reporting data on sex; mean [SD] age, 52 [15] years among 8 studies reporting data on age). Significant clinical and methodologic heterogeneity existed among studies. On random-effects analysis, NPWT was associated with a significantly lower rate of 551 compared with standard dressings (pooled odds ratio [OR], 0.25; 95% Cl, 0.12-0.52; P <.001). However, no difference in rates of seroma (pooled OR, 0.38; 95% Cl, 0.12-1.23; P = .11) or wound dehiscence (pooled OR, 2.03; 95% Cl, 0.61-6.78; P =.25) was found. On sensitivity analysis, focusing solely on colorectal procedures, NPWT significantly reduced 551 rates (pooled OR, 0.16; 95% Cl, 0.07-0.36; P <.001).
   CONCLUSIONS AND RELEVANCE Application of NPVVT on closed laparotomy wounds in general and colorectal surgery is associated with reduced 551 rates but similar rates of seroma and wound dehiscence compared with conventional nonpressure dressings.
C1 [Sahebally, Shaheel Mohammad; McKevitt, Kevin; Stephens, Ian; Deasy, Joseph; Burke, John Patrick; McNamara, Deborah] Beaumont Hosp, Dept Colorectal Surg, Beaumont Rd, Dublin 9, Ireland.
   [Fitzpatrick, Fidelma] Beaumont Hosp, Dept Clin Microbiol, Dublin, Ireland.
   [Fitzpatrick, Fidelma; Burke, John Patrick; McNamara, Deborah] Royal Coll Surgeons Ireland, Dublin, Ireland.
C3 Beaumont Hospital Dublin; Beaumont Hospital Dublin; Royal College of
   Surgeons in Ireland - RCSI
RP Sahebally, SM (通讯作者)，Beaumont Hosp, Dept Colorectal Surg, Beaumont Rd, Dublin 9, Ireland.
EM sahebalm@tcd.ie
RI ; Stephens, Ian/LCE-0459-2024; McNamara, Deborah/AGI-5820-2022;
   fitzpatrick, fidelma/P-5483-2018
OI Deasy, Joseph/0000-0002-9437-266X; Stephens, Ian/0000-0001-5097-4602;
   McNamara, Deborah/0000-0003-3975-0485; fitzpatrick,
   fidelma/0000-0002-3204-5962
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NR 53
TC 132
Z9 141
U1 1
U2 12
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6254
EI 2168-6262
J9 JAMA SURG
JI JAMA Surg.
PD NOV
PY 2018
VL 153
IS 11
AR e183467
DI 10.1001/jamasurg.2018.3467
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HB0PM
UT WOS:000450718300003
PM 30267040
OA Bronze
DA 2026-07-24
ER
PT J
AU Cozza, V
   Pepe, G
   Cintoni, M
   De Maio, F
   Tropeano, G
   Magalini, S
   Sganga, G
   Delogu, G
   Gui, D
AF Cozza, Valerio
   Pepe, Gilda
   Cintoni, Marco
   De Maio, Flavio
   Tropeano, Giuseppe
   Magalini, Sabina
   Sganga, Gabriele
   Delogu, Giovanni
   Gui, Daniele
TI Vacuum-assisted closure (VAC®) systems and microbiological isolation of
   infected wounds
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Infection control; Wound infection;
   Wound contamination
ID BED CHANGES; THERAPY; CONTAMINATION; CARE; MESH
AB Background: Negative pressure wound therapy is now largely used to treat infected wounds. The prevention and reduction of healthcare-associated infections is a high priority for any Department of Health and great efforts are spent to improve infection control systems. It is assumed that vacuum-assisted closure (VAC (R)) dressings should be watertight and that all the secretions are gathered in a single container but there is no consistent data on air leakage and possible dispersion of bacteria from the machine.
   Methods: We have conducted a prospective experimental study on 10 patients with diagnosis of wound infection to verify whether the filtration process is microbiologically efficient. We compared the bacteria population present in the wound to the one present in the air discharged by the VAC (R) machine.
   Results: This study shows that the contamination of the VAC (R) machine is considerably lower than the environment or wound contamination.
   Conclusions: Negative pressure wound therapy system does not represent a risk factor for healthcare-associated infections.
C1 [Cozza, Valerio; Pepe, Gilda; Cintoni, Marco; Tropeano, Giuseppe; Magalini, Sabina; Sganga, Gabriele; Gui, Daniele] Univ Cattolica Sacro Cuore, Fdn Policlin A Gemelli IRCCS, Emergency Surg Dept, Rome, Italy.
   [De Maio, Flavio; Delogu, Giovanni] Univ Cattolica Sacro Cuore, Fdn Policlin A Gemelli IRCCS, Microbiol Dept, Rome, Italy.
   [Cozza, Valerio] Univ Cattolica Sacro Cuore, Ist Clin Chirurg 9B, Largo Francesco Vito 1, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Cozza, V (通讯作者)，Univ Cattolica Sacro Cuore, Fdn Policlin A Gemelli IRCCS, Emergency Surg Dept, Rome, Italy.; Cozza, V (通讯作者)，Univ Cattolica Sacro Cuore, Ist Clin Chirurg 9B, Largo Francesco Vito 1, I-00168 Rome, Italy.
EM Valerio.cozza@policlinicogemelli.it
RI De Maio, Flavio/AAL-7355-2021; Delogu, Giovanni/I-3701-2012
OI De Maio, Flavio/0000-0002-4744-9820; Cintoni, Marco/0000-0002-9610-0748
CR Arundel C, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1661-1
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NR 17
TC 7
Z9 11
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD NOV 20
PY 2018
VL 13
AR 53
DI 10.1186/s13017-018-0216-z
PG 5
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA HB2KQ
UT WOS:000450870200001
PM 30479652
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Bayci, A
   Akay, B
AF Bayci, Andrew
   Akay, Begum
TI Advanced Techniques in the Use of Negative Pressure Wound Therapy for
   Closure of Complex Neonatal Abdominal Wounds
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Complex wound care; Negative pressure wound therapy; Neonatal medicine;
   Pediatric surgery
ID VACUUM-ASSISTED CLOSURE
AB BACKGROUND: Negative pressure wound therapy (NPWT) has been described for closure of complex neonatal abdominal wounds, but advanced techniques for stoma or fistula control, skin protection, and the use of high pressure therapy not as well established.
   CASES: We identified neonatal patients at our institution who received NPWT for a complex abdominal wound, defined as a wound associated with a stoma or fistula with partial or complete dehiscence of the abdominal fascia or skin. We then reviewed techniques for decreasing wound contamination and protecting the newborn's skin. One patient had an especially complex wound; she was born at similar to 23 weeks' gestational age (birth weight 580 g). She developed necrotizing enterocolitis and strictures, requiring multiple surgeries to relieve obstruction, ultimately resulting in an end ileostomy with mucous fistula. She suffered from wound dehiscence and retraction of her surgically created stoma, resulting in a complex abdominal wound with significant damage to the surrounding skin. We used advanced NPWT techniques to heal her wound, including topical skin protectants, placement of an adhesive dressing over the skin prior to placement of negative pressure dressing, placement of a negative pressure sponge directly on the wound bed and stoma, diversion of enteric contents away from the wound using a Malecot catheter, and an increase in the negative pressure applied.
   CONCLUSION: Complex neonatal abdominal wounds can be treated effectively using NPWT. The techniques we describe divert enteric contents away from the wound bed while maintaining negative pressure and protecting the surrounding skin. In addition, we used negative pressure up to -125 mm Hg and found it was well tolerated by our patients.
C1 [Bayci, Andrew] Beaumont Hlth, Dept Gen Surg, Royal Oak, MI USA.
   [Akay, Begum] Beaumont Childrens, Dept Pediat Surg, Royal Oak, MI USA.
C3 Beaumont Health; Beaumont Health
RP Bayci, A (通讯作者)，5021 Prentis Dr, Troy, MI 48085 USA.
EM Andrew.Bayci@gmail.com
CR Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argo R, 2014, J WOUND OSTOMY CONT, V41, P222, DOI 10.1097/WON.0000000000000033
   Boyar V, 2018, J WOUND OSTOMY CONT, V45, P117, DOI 10.1097/WON.0000000000000407
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NR 8
TC 5
Z9 7
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2018
VL 45
IS 5
BP 468
EP 471
DI 10.1097/WON.0000000000000471
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA HB2SD
UT WOS:000450891800013
PM 30188395
DA 2026-07-24
ER
PT J
AU Özer, MT
   Sinan, H
   Sapmaz, E
   Gürkok, S
   Kaymak, S
   Kozak, O
AF Ozer, Mustafa Tahir
   Sinan, Huseyin
   Sapmaz, Ersin
   Gurkok, Sedat
   Kaymak, Sahin
   Kozak, Orhan
TI Negative pressure wound closure system for giant thoracic defect closure
   in a patient with completely visible pericardium: A case report
SO TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND
   CARDIOVASCULAR SURGERY
LA English
DT Article
DE Negative pressure wound therapies; vacuum assisted closure; wound care
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; THERAPY
AB Negative pressure wound closure system facilitates wound closure via wound contraction. In this article, we report a successful application of thoracic negative pressure wound closure system to fill the thoracic defect, control infection, and expand the lung in a 35-year-old male patient with three-rib defect, lung parenchyma injury, empyema, left complete pneumothorax, and visible pericardium after gunshot injury. The excellent result obtained in our patient demonstrates that negative pressure wound closure system is a good choice for treating high-energy thoracic injuries by reducing wound infection and enabling early wound closure.
C1 [Ozer, Mustafa Tahir; Kaymak, Sahin] Univ Hlth Sci, Gulhane Training & Res Hosp, Dept War Surg, Ankara, Turkey.
   [Sinan, Huseyin; Kozak, Orhan] Univ Hlth Sci, Gulhane Training & Res Hosp, Dept Gen Surg, Ankara, Turkey.
   [Sapmaz, Ersin; Gurkok, Sedat] Univ Hlth Sci, Gulhane Training & Res Hosp, Dept Thorac Surg, Ankara, Turkey.
C3 University of Health Sciences Turkey; Gulhane Training & Research
   Hospital; University of Health Sciences Turkey; Gulhane Training &
   Research Hospital; University of Health Sciences Turkey; Gulhane
   Training & Research Hospital
RP Sinan, H (通讯作者)，Gulhane Egitim & Arastirma Hastanesi, Genel Cerrahi Klin, TR-06010 Ankara, Turkey.
EM huseyinsinan@gmail.com
RI ; Sapmaz, Ersin/G-1398-2015; KAYMAK, SAHIN/QOB-0010-2026
OI Kozak, Orhan/0000-0002-7302-1203; Kaymak, Şahin/0000-0003-4717-5791; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Begum SSS, 2012, ANN THORAC SURG, V94, P1835, DOI 10.1016/j.athoracsur.2012.08.009
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NR 16
TC 0
Z9 0
U1 0
U2 5
PU BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
PI ATASEHIR
PA ORNEK MH DR SUPHI EZGI SK SARAY APT NO 11 D 6, ATASEHIR, ISTANBUL 34704,
   TURKEY
SN 1301-5680
J9 TURK GOGUS KALP DAMA
JI Turk Gogus Kalp Damar Cerrahisi Derg.
PD OCT
PY 2018
VL 26
IS 4
BP 668
EP 672
DI 10.5606/tgkdc.dergisi.2018.15703
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HB3AC
UT WOS:000450917400024
PM 32082815
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Lin, PY
   Liou, TL
   Lin, KC
   Hsieh, MH
   Chien, CY
   Hsieh, CH
AF Lin, Pao-Yuan
   Liou, Tz-Luen
   Lin, Ko-Chien
   Hsieh, Mu-Han
   Chien, Chih-Yen
   Hsieh, Ching-Hua
TI Immediate Negative Pressure Wound Therapy After Free Flap Transfer for
   Head and Neck Cancer Surgery
SO LARYNGOSCOPE
LA English
DT Article
DE Free flap; head and neck reconstruction; negative pressure wound
   therapy; standard care; wound infection; complication
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; RECONSTRUCTION; MULTICENTER;
   DISSECTION
AB Objective Methods This study aimed to assess the outcomes of administering negative-pressure wound therapy (NPWT) in patients immediately following free flap reconstruction after head and neck cancer surgery and radical neck lymph node dissection. The outcomes were compared with those of patients who received conventional wound care (CWC). A retrospective analysis was performed for 58 patients with head and neck cancer who underwent free flap reconstruction after tumor ablation and radical neck dissection between February 1, 2016, and October 31, 2016. All reconstructions were performed by the same plastic surgeon. Charts were reviewed for patient demographics, comorbidities, cancer type, operation time, flap type, postoperative drainage volume, complication rates, length of hospital stay, and wound outcomes. Results Conclusion No significant difference was observed between patients receiving NPWT and CWC regarding operation time and drainage volume from the vacuum ball. After the application of NPWT, no patients experienced flap failure or developed a wound infection. Significantly fewer patients receiving NPWT developed complications (9.7% vs. 37.0%; P = 0.025) and developed infections (0.0% vs. 14.8%; P = 0.041) compared with those receiving CWC. On the basis of fewer associated complications and infections, this study supports the immediate use of NPWT after free flap reconstruction in patients who have undergone head and neck cancer ablation and radical neck lymph node dissection. Level of Evidence 4. Laryngoscope, 2478-2482, 2018
C1 [Lin, Pao-Yuan; Liou, Tz-Luen; Lin, Ko-Chien; Hsieh, Mu-Han; Hsieh, Ching-Hua] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Kaohsiung, Taiwan.
   [Chien, Chih-Yen] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung, Taiwan.
   Coll Med, Kaohsiung, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital
RP Hsieh, CH (通讯作者)，Kaohsiung Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, 123 Ta Pei Rd, Kaohsiung 83301, Taiwan.; Hsieh, CH (通讯作者)，Chang Gung Univ, Coll Med, 123 Ta Pei Rd, Kaohsiung 83301, Taiwan.
EM m93chinghua@gmail.com
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NR 31
TC 17
Z9 17
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD NOV
PY 2018
VL 128
IS 11
BP 2478
EP 2482
DI 10.1002/lary.27169
PG 5
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA HC2IG
UT WOS:000451624900015
PM 30247762
DA 2026-07-24
ER
PT J
AU Loske, G
   Müller, CT
AF Loske, G.
   Mueller, C. T.
TI Tips and tricks for endoscopic negative pressure therapy. German version
SO CHIRURG
LA German
DT Article
DE Endoscopic vacuum therapy; Leakage; Drainage; Overtube; Esophagus
ID OPEN-PORE FILM; VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE;
   POLYURETHANE FOAM; DRAINAGE; DEVICE; PERFORATION; ABSCESS; EVT
AB Endoscopic negative-pressure therapy (ENPT) is becoming avaluable tool in surgical complication management of transmural intestinal defects and wounds in the upper and lower gastrointestinal tract. Innovative materials for drains have been developed, endoscopic techniques adapted, and new indications for ENPT have been found. Based on our broad clinical experience, numerous tips and tricks are described, which contribute to the safety of dealing with the new therapy. The aim of this work is to present these methods. The focus is on describing the treatment in the esophagus.
C1 [Loske, G.; Mueller, C. T.] Katholisches Marienkrankenhaus Hamburg gGmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
C3 St. Marien Hospital
RP Loske, G (通讯作者)，Katholisches Marienkrankenhaus Hamburg gGmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
EM Loske.chir@marienkrankenhaus.org
CR Bludau M, 2018, SURG ENDOSC, V32, P1906, DOI 10.1007/s00464-017-5883-4
   Fischer A, 2016, ENDOSC INT OPEN, V4, pE937, DOI 10.1055/s-0042-111078
   Kirschner M, 1926, ARCH KLIN CHIR, V142, P253
   Krajinovic K, 2016, SURG CASE REP, V2, DOI 10.1186/s40792-016-0243-5
   Kuehn F, 2017, SURG ENDOSC, V31, P3449, DOI 10.1007/s00464-016-5404-x
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   Lee So Young, 2018, Korean J Thorac Cardiovasc Surg, V51, P76, DOI [10.5090/kjtcs.2018.51.1.76, 10.5090/kjtcs.2018.51.1.76]
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   Loske G, 2018, ENDOSC INT OPEN, V6, pE865, DOI 10.1055/a-0599-5886
   Loske G, 2017, ENDOSCOPY, V49, pE294, DOI 10.1055/s-0043-118211
   Loske G, 2017, ENDOSCOPY, V49, pE300, DOI 10.1055/s-0043-119346
   Loske G, 2016, ENDOSCOPY, V48, pE148, DOI 10.1055/s-0042-106576
   Loske G, 2016, ENDOSCOPY, V48, pE154, DOI 10.1055/s-0042-105364
   Loske G, 2015, ENDOSCOPY, V47, pE577, DOI 10.1055/s-0034-1393388
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NR 25
TC 8
Z9 9
U1 0
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD NOV
PY 2018
VL 89
IS 11
BP 887
EP 895
DI 10.1007/s00104-018-0715-1
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HC4JO
UT WOS:000451769800007
PM 30288601
OA hybrid
DA 2026-07-24
ER
PT J
AU Borys, S
   Hohendorff, J
   Koblik, T
   Witek, P
   Ludwig-Slomczynska, AH
   Frankfurter, C
   Kiec-Wilk, B
   Malecki, MT
AF Borys, S.
   Hohendorff, J.
   Koblik, T.
   Witek, P.
   Ludwig-Slomczynska, A. H.
   Frankfurter, C.
   Kiec-Wilk, B.
   Malecki, M. T.
TI Negative-pressure wound therapy for management of chronic neuropathic
   noninfected diabetic foot ulcerations - short-term efficacy and
   long-term outcomes
SO ENDOCRINE
LA English
DT Article
DE Negative-pressure wound therapy; Diabetic foot syndrome; Type 2 diabetes
ID IWGDF GUIDANCE; ULCERS; AMPUTATION; PREVENTION; MULTICENTER; DISEASE
AB PurposeNegative pressure wound therapy (NPWT) is an adjunct method used in the treatment of diabetic foot ulceration (DFU). Real world data on its effectiveness and safety is scarce. In this prospective observational study, we assessed the short-term efficacy, safety, and long-term outcomes of NPWT in patients with type 2 diabetes (T2DM) and neuropathic, noninfected DFUs.MethodsBased on wound characteristics, mainly area (>1 vs. 1cm(2)), 75 patients with DFUs treated in an outpatient clinic were assigned to NPWT (n=53) or standard therapy (n=22). Wound area reduction was evaluated after 81 days. Long-term outcomes assessed included complete ulceration closure and recurrence rate.ResultsPatients assigned to NPWT were characterized by greater wound area (15.7 vs. 2.9cm(2)). Reduction in wound area was found in both the NPWT (-1.1cm(2), -10.2%, p=0.0001) and comparator group (-0.3cm(2), -18.0%, p=0.0038). No serious adverse events related to NPWT were noted. Within 1 year, 55.1% (27/49) of DFUs were closed in the NPWT group and 73.7% (14/19) in the comparator group (p=0.15). In the logistic regression, wound duration and smaller initial area, but not treatment mode, were associated with closure. One-year follow-up after DFU resolution revealed an 30.0% recurrence rate in both groups (p=0.88).ConclusionsNPWT is a safe treatment for neuropathic, nonischemic, and noninfected DFU in patients with T2DM, although this observational study did not prove its effectiveness over standard therapy. Additionally, we report a high rate of both closure and recurrence of ulcers, the latter irrespective of initial ulcer area.
C1 [Borys, S.; Hohendorff, J.; Koblik, T.; Witek, P.; Kiec-Wilk, B.; Malecki, M. T.] Univ Hosp Krakow, Dept Metab Dis, Krakow, Poland.
   [Borys, S.; Hohendorff, J.; Witek, P.; Kiec-Wilk, B.; Malecki, M. T.] Jagiellonian Univ, Dept Metab Dis, Med Coll, Krakow, Poland.
   [Ludwig-Slomczynska, A. H.] Jagiellonian Univ, Ctr Med Genom OMICRON, Med Coll, Krakow, Poland.
   [Frankfurter, C.] Univ Toronto, Fac Med, Toronto, ON, Canada.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   University of Toronto
RP Malecki, MT (通讯作者)，Univ Hosp Krakow, Dept Metab Dis, Krakow, Poland.; Malecki, MT (通讯作者)，Jagiellonian Univ, Dept Metab Dis, Med Coll, Krakow, Poland.
EM malecki_malecki@yahoo.com
RI ; Hohendorff, Jerzy/U-1857-2018; Witek, Przemysław/AGX-0421-2022
OI Ludwig-Słomczyńska, Agnieszka H/0000-0002-0548-4767; Hohendorff,
   Jerzy/0000-0003-1153-8669; 
FU National Science Centre in Poland through the Opus Grant "Assessment of
   molecular mechanisms of negative pressure wound therapy in the treatment
   of neuropathic ulceration in diabetic foot syndrome"
   [2013/11/B/NZ5/03298]; European Union (7th Framework Programme)
   [FP7-REGPOT-2011-1, 286038]
FX The study was funded by the National Science Centre in Poland through
   the Opus Grant "Assessment of molecular mechanisms of negative pressure
   wound therapy in the treatment of neuropathic ulceration in diabetic
   foot syndrome" to MTM (Nr 2013/11/B/NZ5/03298). The Omicron laboratory
   (where the microarray experiments were performed) was funded by the
   European Union (7th Framework Programme, Call number FP7-REGPOT-2011-1,
   Grant number 286038).
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NR 27
TC 29
Z9 44
U1 0
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD DEC
PY 2018
VL 62
IS 3
BP 611
EP 616
DI 10.1007/s12020-018-1707-0
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HC6ZS
UT WOS:000451950800014
PM 30099674
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Arundel, C
   Fairhurst, C
   Corbacho-Martin, B
   Buckley, H
   Clarke, E
   Cullum, N
   Dixon, S
   Dumville, J
   Firth, A
   Hendetson, E
   Lamb, K
   McGinnis, E
   Oswald, A
   Goncalves, PS
   Soares, MO
   Stubbs, N
   Chetter, 
AF Arundel, C.
   Fairhurst, C.
   Corbacho-Martin, B.
   Buckley, H.
   Clarke, E.
   Cullum, N.
   Dixon, S.
   Dumville, J.
   Firth, A.
   Hendetson, E.
   Lamb, K.
   McGinnis, E.
   Oswald, A.
   Goncalves, P. Saramago
   Soares, M. O.
   Stubbs, N.
   Chetter, I
TI Pilot feasibility randomized clinical trial of negative-pressure wound
   therapy versus usual care in patients with surgical wounds
   healing by secondary intention
SO BJS OPEN
LA English
DT Article
AB Background: Surgical wounds healing by secondary intention (SWHSI) are increasingly being treated with negative-pressure wound therapy (NPWT) despite a lack of high-quality research evidence regarding its clinical and cost-effectiveness. This pilot feasibility RCT aimed to assess the methods for and feasibility of conducting a future definitive RCT of NPWT for the treatment of SWHSI.
   Methods: Eligible consenting adult patients receiving care at the study sites (2 acute and 1 community) and with a SWHSI appropriate for NPWT or wound dressing treatment were randomized 1:1 centrally to receive NPWT or usual care (no NPWI). Participants were followed up every 1-2 weeks for 3 months. Feasibility (recruitment rate, time to intervention delivery) and clinical (time to wound healing) outcomes were assessed.
   Results: A total of 248 participants were screened for eligibility; 40 (16.1 per cent) were randomized, 19 to NPWT and 21 to usual care. Twenty-four of the 40 wounds were located on the foot. Participants received NPWT for a median of 18 (range 0-72) days. Two participants in the NPWT group never received the intervention and 14 received NPWT within 48 h of randomization. Five participants in the usual care group received NPWT during the study. Ten of the 40 wounds were deemed to have healed during the study.
   Conclusion: A full-scale RCT to investigate the clinical and cost-effectiveness of NPWT for SWHSI is feasible. This study identified crucial information on recruitment rates and data collection methods to consider during the design of a definitive RCT.
C1 [Arundel, C.; Fairhurst, C.; Corbacho-Martin, B.; Buckley, H.] Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England.
   [Goncalves, P. Saramago; Soares, M. O.; Chetter, I] Univ York, Ctr Hlth Econ, York, N Yorkshire, England.
   [Clarke, E.; Firth, A.; Oswald, A.] Hull & East Yorkshire Hosp NHS Trust, Acad Vasc Surg Unit, Kingston Upon Hull, N Humberside, England.
   [Dixon, S.] Patient & Publ Involvement Grp, Kingston Upon Hull, N Humberside, England.
   [Hendetson, E.] Hull & East Yorkshire Hosp NHS Trust, Outpatient Serv, Kingston Upon Hull, N Humberside, England.
   [Chetter, I] Hull York Med Sch, Res Off, Kingston Upon Hull, N Humberside, England.
   [Cullum, N.; Dumville, J.] Univ Manchester, Fac Biol Med & Hlth, Sch Hlth Sci, Div Nursing Midwifery & Social Work, Manchester, Lancs, England.
   [Cullum, N.] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Res & Innovat Div, Manchester, Lancs, England.
   [Lamb, K.; Stubbs, N.] Leeds Community Healthcare NHS Trust, Leeds Wound Res Unit, Leeds, W Yorkshire, England.
   [McGinnis, E.] Leeds Teaching Hosp NHS Trust, Dept Tissue Viabil, Leeds, W Yorkshire, England.
C3 University of York - UK; University of York - UK; University of Hull;
   University of York - UK; University of Hull; University of Manchester;
   University of Manchester; University of Leeds
RP Arundel, C (通讯作者)，Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England.
EM catherine.arundel@york.ac.uk
RI Soares, Marta Ferreira Oliveira/HJH-3434-2023; Cullum,
   Nicky/F-2438-2011; McGinnis, Elizabeth/PNF-2864-2026; Buckley,
   Hannah/QAX-3702-2026; Dumville, Jo/O-7867-2014
OI Soares, Marta Ferreira Oliveira/0000-0003-1579-8513; Arundel,
   Catherine/0000-0003-0512-4339; McGinnis, Elizabeth/0000-0002-2848-9149;
   chetter, ian/0000-0002-2566-6859; 
FU National Institute for Health Research (NIHR) Programme Grants for
   Applied Research (PGfAR) programme [RP-PG-0609-10171]; National
   Institute for Health Research [NF-SI-0512-10028, NF-SI-0617-10129,
   RP-PG-0609-10171] Funding Source: researchfish; National Institutes of
   Health Research (NIHR) [RP-PG-0609-10171] Funding Source: National
   Institutes of Health Research (NIHR)
FX This project was funded by the National Institute for Health Research
   (NIHR) Programme Grants for Applied Research (PGfAR) programme (project
   number RP-PG-0609-10171). The views and opinions in this publication are
   those of the authors and do not necessarily reflect those of the NHS,
   the NIHR, the Medical Research Council, the NIHR Central Commissioning
   Facility, the NIHR Evaluation, Trials and Studies Coordinating Centre,
   the PGfAR programme or the Department of Health.
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   Norman G, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011712.pub2
   Taylor R J, 1997, J Wound Care, V6, P123
   UKForex Limited, YEARL AV RAT
   Vermeulen H, 2005, BJS-BRIT J SURG, V92, P665, DOI 10.1002/bjs.5055
NR 19
TC 7
Z9 8
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD JUN
PY 2018
VL 2
IS 3
BP 99
EP 111
DI 10.1002/bjs5.49
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HC8XZ
UT WOS:000452090000002
PM 29951633
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Goda, H
   Hamakawa, T
   Nakashiro, KI
AF Goda, Hiroyuki
   Hamakawa, Tomohiro
   Nakashiro, Koh-Ichi
TI Successful management of an orocutaneous fistula and exposed mandibular
   plate with the vacuum-assisted closure system: A case report
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE vacuum-assisted closure; mandibular plate exposure; orocutaneous fistula
ID WOUND CONTROL; THERAPY; DEVICE
AB Orocutaneous fistulas are one of the most problematic postoperative complications after oral cancer surgery. Notably, in patients with mandibular plate exposure it is necessary to remove the plate. However, it takes longer for these patients to achieve complete fistula closure. The present report described an 84-year-old man with a postoperative orocutaneous fistula and exposed mandibular plate who was treated with the vacuum-assisted closure system. This system protects the wound from contamination while the negative pressure prevents tissue fluid retention, promotes blood flow, facilitates granulation tissue formation and decreases the bacterial cell count. Vacuum-assisted closure was successful in the present case, and complete fistula closure took 20 days. Additionally, there was no evidence of recurrence over the 11-month follow-up.
C1 [Goda, Hiroyuki; Hamakawa, Tomohiro; Nakashiro, Koh-Ichi] Ehime Univ, Grad Sch Med, Dept Oral & Maxillofacial Surg, 454 Shitsukawa, Toon, Ehime 7910204, Japan.
C3 Ehime University
RP Goda, H (通讯作者)，Ehime Univ, Grad Sch Med, Dept Oral & Maxillofacial Surg, 454 Shitsukawa, Toon, Ehime 7910204, Japan.
EM hiro9832@m.ehime-u.ac.jp
RI Nakashiro, Koh-ichi/AAV-6317-2020
OI Nakashiro, Koh-ichi/0000-0002-9975-902X
CR Andrews BT, 2008, ANN OTO RHINOL LARYN, V117, P298, DOI 10.1177/000348940811700410
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NR 14
TC 4
Z9 4
U1 0
U2 1
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD DEC
PY 2018
VL 16
IS 6
BP 5315
EP 5317
DI 10.3892/etm.2018.6869
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HC9UF
UT WOS:000452151700139
PM 30542489
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yuan, W
   Liu, X
   Zhou, XS
   Pei, L
   Zhu, Y
AF Yuan, Wei
   Liu, Xuan
   Zhou, Xiaoshu
   Pei, Lei
   Zhu, Yue
TI Management of Early Deep Wound Infection After Thoracolumbar
   Instrumentation Continuous Irrigation Suction System versus
   Vacuum-Assisted Closure System
SO SPINE
LA English
DT Article
DE continuous irrigation suction system; deep wound infection; early;
   outcomes; thoracolumbar instrumentation; vacuum-assisted closure system
ID SURGICAL SITE INFECTIONS; POSTERIOR SPINAL-FUSION; RISK-FACTORS;
   POSTOPERATIVE INFECTIONS; THERAPY; SURGERY; PREVENTION; DIAGNOSIS;
   ADULTS
AB Study Design. A retrospective study.
   Objective. The aim of this study was to compare the clinical outcomes of continuous irrigation suction systems (CISS) or vacuum-assisted closure system (VACS) in early deep wound infection (DWI) after thoracolumbar instrumentation.
   Summary of Background Data. DWI after thoracolumbar instrumentation is challenging and debridement followed by either CISS or VACS has been proven to be effective. So far, which one of the system has more advantages over the other remains unclear.
   Methods. Patients after thoracolumbar instrumentation were evaluated at our spine surgery center from 2005 to 2015. Patients who were diagnosed with early deep DWI after spinal instrumentation and treated by meticulous debridement in the operating room followed by either CISS or VACS were included. Detailed information was obtained from the medical records, including clinical features, results of laboratory examinations, medical therapies, and outcomes. A follow-up was conducted to observe whether recurrent spinal infection or other complications happened.
   Results. We identified 11 patients in the CISS group and 12 patients in the VACS group. There were no significant differences in terms of age, gender, follow-up duration, symptoms of infection, laboratory examinations, etc. The number of CISS or VACS replacement was 1.3 and 1.6, respectively, before wound healing (P>0.05). And there were significant differences in terms of hospital stay and extra cost of infection treatment between the two groups. In the follow-up period, we observed sinus tract formation and low back pain in both groups and one patient in the VACS group died of pulmonary infection 4 years after the initial surgery.
   Conclusion. Thorough debridement followed by CISS or VACS are comparable in treating early DWI after thoracolumbar instrumentation. The CISS treatment was statistically significant in comparison to the VACS treatment in terms of hospital stay and cost.
C1 [Yuan, Wei; Liu, Xuan; Zhou, Xiaoshu; Pei, Lei; Zhu, Yue] China Med Univ, Hosp 1, Dept Orthoped, Shenyang, Liaoning, Peoples R China.
C3 China Medical University
RP Zhu, Y (通讯作者)，China Med Univ, Hosp 1, 155 Nanjingbei St, Shenyang 110001, Liaoning, Peoples R China.
EM zhuyuedr@163.com
OI yuan, wei/0000-0003-4012-4350
FU National Key Research and Development Program of China [2017YFC1104903]
FX National Key Research and Development Program of China (2017YFC1104903)
   funds were received in support of this work.
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NR 35
TC 12
Z9 19
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0362-2436
EI 1528-1159
J9 SPINE
JI SPINE
PD SEP 15
PY 2018
VL 43
IS 18
BP E1089
EP E1095
DI 10.1097/BRS.0000000000002615
PG 7
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA HD0AE
UT WOS:000452169000007
PM 29481377
DA 2026-07-24
ER
PT J
AU Loske, G
AF Loske, G.
TI Endoscopic negative pressure therapy of the upper gastrointestinal
   tract. German version
SO CHIRURG
LA German
DT Article
DE Endoscopic vacuum therapy; Esophagus; Drainage; Anastomotic leakage;
   Perforation
ID OPEN-PORE FILM; VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE; DUODENAL
   PERFORATION; TREATMENT OPTIONS; DRAINAGE; DEVICE; ESOPHAGECTOMY;
   INSUFFICIENCY; GASTROSTOMY
AB Endoscopic negative pressure therapy (ENPT) has been adapted for upper gastrointestinal tract applications. More than 400 patients have already been treated with ENPT due to transmural defects in the upper gastrointestinal tract, with a success rate of 87%. The greatest experience exists for the treatment of anastomotic leakages and perforations of the esophagus. The ENPT is also used in the duodenum, pancreas and for complications after bariatric surgery. There are new indications that go beyond treatment in complication management. Innovative drainage types and endoscopic techniques have been developed that broaden the spectrum of applications. The aim of this article is to give an overview of the current status of ENPT in the upper gastrointestinal tract.
C1 [Loske, G.] Katholisches Marienkrankenhaus Hamburg gGmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
C3 St. Marien Hospital
RP Loske, G (通讯作者)，Katholisches Marienkrankenhaus Hamburg gGmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
EM loske.chir@marienkrankenhaus.org
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NR 64
TC 5
Z9 6
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD DEC
PY 2018
VL 89
IS 12
BP 952
EP 959
DI 10.1007/s00104-018-0728-9
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HD1WS
UT WOS:000452303700003
PM 30306230
OA hybrid
DA 2026-07-24
ER
PT J
AU Vieira, ALG
   Stocco, JGD
   Ribeiro, ACG
   Frantz, CV
AF Gomide Vieira, Ana Laura
   Dorociaki Stocco, Janislei Giseli
   Gaspar Ribeiro, Anna Carolina
   Frantz, Cristina Valeria
TI Dressings used to prevent surgical site infection in the postoperative
   period of cardiac surgery: integrative review
SO REVISTA DA ESCOLA DE ENFERMAGEM DA USP
LA English
DT Review
DE Cardiovascular Nursing; Thoracic Surgery; Surgical Wound Infection;
   Review
ID WOUND INFECTIONS; CLINICAL-TRIAL; QUALITY; CARE
AB Objective: To identify and describe which dressings are recommended to prevent surgical site infection in hospitalized adult patients after cardiac surgeries. Method: Integrative review carried out in the databases MEDLINE, LILACS, CINAHL, Web of Science, Cochrane and Scopus. Studies related to dressing in the postoperative period of cardiac surgery were selected. Results: Seven articles were included, with the following dressings: negative pressure wound therapy, silver nylon dressing, transdermal delivery of continuous oxygen and impermeable adhesive drape. The dressings that led to reduction of infection were negative pressure and silver nylon dressings. Conclusion: It was not possible to identify which dressing is most recommended, however, some studies show that certain types of dressings were related to the reduction of infection. Clinical trials with a rigorous methodological design and representative samples able to minimize the risk of bias should be conducted to evaluate the effectiveness of dressings in the prevention of surgical site infection.
C1 [Gomide Vieira, Ana Laura; Frantz, Cristina Valeria] Univ Fed Parana, Hosp Clin, Programa Residencia Integrada Multiprofiss Atenca, Curitiba, PR, Brazil.
   [Dorociaki Stocco, Janislei Giseli] Univ Fed Parana, Hosp Clin, Serv Controle Infeccao Hosp, Curitiba, PR, Brazil.
   [Gaspar Ribeiro, Anna Carolina] Univ Fed Parana, Hosp Clin, Ctr Terapia Intens Cardiol, Curitiba, PR, Brazil.
C3 Universidade Federal do Parana; Universidade Federal do Parana;
   Universidade Federal do Parana
RP Vieira, ALG (通讯作者)，Rua Gen Carneiro,181 Bairro Alto Gloria, BR-80060900 Curitiba, PR, Brazil.
EM analaura.gov@gmail.com
OI Gaspar Ribeiro, Anna Carolina/0000-0002-8523-7634
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   National Institute for Health and Care Excellence, 2013, SURG SIT INF PREV TR
   National Institute for Health and Care Excellence (NICE), 2020, Surgical Site Infections: Prevention and Treatment: NG125
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   Wells GA., 2020, NEWCASTLE OTTAWA SCA
   World Health Organization. Media Centre, 2014, TOP 10 CAUS DEATH
NR 35
TC 11
Z9 14
U1 0
U2 11
PU UNIV SAO PAOLO
PI CERQUERA CESAR
PA AV  DR ENEAS DE CARVALHO AGUIAR, 419, CERQUERA CESAR, SP 05403-000,
   BRAZIL
SN 0080-6234
EI 1980-220X
J9 REV ESC ENFERM USP
JI Rev. Esc. Enferm. USP
PY 2018
VL 52
AR e03393
DI 10.1590/S1980-220X2017011803393
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA HD3TG
UT WOS:000452442700001
PM 30517290
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Krpata, DM
AF Krpata, David M.
TI Wound Closure and Management
SO SURGICAL INFECTIONS
LA English
DT Article; Proceedings Paper
CT 38th Annual Meeting of the Surgical-Infection-Society
CY APR 22-26, 2018
CL Westlake Village, CA
SP Surg Infect Soc
DE fascial closure; skin closure; wound closure; wound management
ID SURGICAL SITE INFECTIONS; SKIN CLOSURE; DELAYED PRIMARY; SUBCUTICULAR
   SUTURES; ABDOMINAL-SURGERY; OPEN-LABEL; MULTICENTER; METAANALYSIS;
   STAPLES; STITCH
AB Background: The management of incisions and decisions on closure techniques for surgical wounds are driven by expected incisional morbidity and the severity of the potential morbidity for the patient. Methods: This article reviews current literature on the potential strategies to be considered in closing the skin and fascia of incisions. Results: The review of the literature indicates that low-risk wounds for infection should be closed primarily with subcuticular suture, and adjunctive local measures should be avoided. Adjunctive measures of irrigation, topical antimicrobial agents, and negative pressure incisional therapy may have a role in high-risk wounds. Surgeons should strongly consider primary closure of contaminated wounds. Conclusions: The overall literature on adjuncts of wound irrigation, topical antimicrobials, and negative pressure wound therapy have potential to be of benefit but additional investigation is necessary since they do impact cost, patient experience, and antibiotic stewardship.
C1 [Krpata, David M.] Cleveland Clin Fdn, Comprehens Hernia Ctr, Digest Dis & Surg Inst, 9500 Euclid Ave,A-100, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation
RP Krpata, DM (通讯作者)，Cleveland Clin Fdn, Comprehens Hernia Ctr, Digest Dis & Surg Inst, 9500 Euclid Ave,A-100, Cleveland, OH 44195 USA.
EM krpatad@ccf.org
CR [Anonymous], COCHRANE DATABASE SY
   Bhangu A, 2013, JAMA SURG, V148, P779, DOI 10.1001/jamasurg.2013.2336
   Deerenberg EB, 2015, LANCET, V386, P1254, DOI 10.1016/S0140-6736(15)60459-7
   Duttaroy DD, 2009, SURG INFECT, V10, P129, DOI 10.1089/sur.2007.030
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   Tsujinaka T, 2013, LANCET, V382, P1105, DOI 10.1016/S0140-6736(13)61780-8
NR 17
TC 2
Z9 3
U1 0
U2 17
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD FEB
PY 2019
VL 20
IS 2
SI SI
BP 135
EP 138
DI 10.1089/sur.2018.235
EA DEC 2018
PG 4
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Infectious Diseases; Surgery
GA HS5PZ
UT WOS:000452714200001
PM 30526404
DA 2026-07-24
ER
PT J
AU Manfredi, MA
   Clark, SJ
   Staffa, SJ
   Ngo, PD
   Smithers, CJ
   Hamilton, TE
   Jennings, RW
AF Manfredi, Michael A.
   Clark, Susannah J.
   Staffa, Steven J.
   Ngo, Peter D.
   Smithers, C. Jason
   Hamilton, Thomas E.
   Jennings, Russell W.
TI Endoscopic Esophageal Vacuum Therapy: A Novel Therapy for Esophageal
   Perforations in Pediatric Patients
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Article
DE esophageal atresia; esophageal leak; esophageal perforation; esophageal
   stent; esophageal vacuum-assisted closure; negative-pressure wound
   therapy
ID ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE; STENT; MANAGEMENT; DEFECTS
AB Background: Esophageal perforation is a potentially life-threatening problem if not quickly diagnosed and treated appropriately. Negative-pressure wound therapy, commercially known as V.A.C. therapy, was developed in the early 1990s and is now standard of care for chronic surface wounds, ulcers, and burns. Adapting vacuum sponge therapy for use intraluminally for perforations of the esophagus was first reported in 2008. We report the first pediatric experience on a customized esophageal vacuum-assisted closure (EVAC) device for closure of esophageal perforations. Aim: To evaluate the technical feasibility, safety, and efficacy of EVAC in a pediatric population with esophageal perforations and compare efficacy to a cohort of patients who underwent stenting for esophageal perforation. Methods: We performed an institutional review board-approved retrospective chart review on all patients who underwent EVAC for esophageal perforations (October 2013-September 2017) and who underwent externally removable stent placement for esophageal perforation (January 2010-December 2017) at our institution. Our primary aim was to evaluate technical feasibility, efficacy, and safety in the treatment of pediatric esophageal perforations. A secondary aim was to compare the efficacy of EVAC to esophageal stenting in healing esophageal perforations in our pediatric population. Results: A total of 17 patients with esophageal atresia underwent therapy for esophageal perforation. Eight sponges were placed for surgical perforation and 9 were placed after endoscopic therapy perforation. The median age of patients was 24 months with the youngest patient being 3 months of age. The success rate of EVAC to seal all esophageal perforations was 88% (15/17). The success rate was similar in both subgroups: surgical anastomotic leaks at 88% (7/8) and endoscopic therapy leaks at 89% (8/9). There were no technical failures with placement. The stent group had a total of 24 patients: 19 were placed secondary to perforations from endoscopic therapy and 5 were placed secondary to surgical anastomotic perforations. The success rate of stents to seal all esophageal perforations was 63% (15/24). The success rate in the subgroups was 74% (14/19) for endoscopic therapy leaks and 20% (1/5) for surgical anastomotic leaks. In comparing success of EVAC and stent therapy, we found a statistically significant difference in favor of EVAC in healing surgical anastomotic perforations (P = 0.032). There was, however, no statistical difference in healing endoscopic therapy perforations (P = 0.360). Conclusions: EVAC is a novel, promising technique for the treatment of esophageal perforations in a pediatric population. This treatment is comparable to esophageal stenting in iatrogenic endoscopic therapy perforations and superior to stenting surgical perforations. Further prospective studies are needed to compare the effectiveness of EVAC to esophageal stenting. Improvement in device design and customization could further improve success and ease of placement.
C1 [Manfredi, Michael A.; Ngo, Peter D.] Boston Childrens Hosp, Div Gastroenterol, Boston, MA USA.
   [Manfredi, Michael A.; Clark, Susannah J.; Ngo, Peter D.; Smithers, C. Jason; Hamilton, Thomas E.; Jennings, Russell W.] Boston Childrens Hosp, Esophageal & Airway Treatment Ctr, Boston, MA USA.
   [Clark, Susannah J.; Smithers, C. Jason; Hamilton, Thomas E.; Jennings, Russell W.] Boston Childrens Hosp, Dept Surg, Boston, MA USA.
   [Staffa, Steven J.] Boston Childrens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital; Harvard
   University; Harvard University Medical Affiliates; Boston Children's
   Hospital
RP Manfredi, MA (通讯作者)，Boston Childrens Hosp, 300 Longwood Ave, Boston, MA 02132 USA.
EM Michael.Manfredi@childrens.harvard.edu
RI Hamilton, Thomas/GQB-4837-2022
OI Clark, Susannah/0000-0003-4873-0582
CR Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
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NR 17
TC 46
Z9 59
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD DEC
PY 2018
VL 67
IS 6
BP 706
EP 712
DI 10.1097/MPG.0000000000002073
PG 7
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA HD8CI
UT WOS:000452781500011
PM 29927863
DA 2026-07-24
ER
PT J
AU Qiu, E
   Kurlander, DE
   Ghaznavi, AM
AF Qiu, Emily
   Kurlander, David E.
   Ghaznavi, Amir M.
TI Godina revisited: a systematic review of traumatic lower extremity wound
   reconstruction timing
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Review
DE Lower extremity reconstruction; free flap; infection
ID SOFT-TISSUE RECONSTRUCTION; VACUUM-ASSISTED CLOSURE; OPEN TIBIAL
   FRACTURES; MICROSURGICAL RECONSTRUCTION; FLAP COVERAGE; IIIB;
   TRANSPLANTATION; MANAGEMENT; DEFECTS; THERAPY
AB Backround: Marko Godina suggested in 1986 that soft tissue coverage of traumatic extremity wounds within 72 h of injury optimizes outcomes. Decades later, these recommendations remain controversial.
   Methods: We performed systematic review of the literature using keywords 'free flap coverage' OR 'soft-tissue reconstruction' AND 'lower extremity trauma' OR 'tibial or fibular fractures'. Patients receiving free flap or local muscle or fascia flaps were included. Patients were divided into two groups, one receiving coverage within 72 h of injury (<72 h) and one after 72 h (>72 h). Primary outcome measures were partial and total flap loss, as well as infection. Use of negative pressure wound therapy (NPWT) was noted. Descriptive statistics were performed.
   Results: Twenty-one publications from 1986 to 2015 were included. The <72 h group had 295 patients and the >72 h group 972 patient. Total flap failure rate was 1.4% if coverage was performed <72 h after injury and 8.8% if >72 h after injury. Partial flap failure rate was 0.4% if coverage was performed <72 h after injury and 1.8% if >72 h after injury. Infection rate was 7.7% if coverage was performed <72 h after injury and 11.6% if >72 h after injury. Among the 182 patients in the >72 h group receiving NPWT, total flap failure rate was 3.6% and total infection rate 7.3%.
   Conclusions: Total and partial flap loss rates, as well as infection rates, were lower when coverage was performed within 72 h of injury. Supporting Godina's recommendation, early soft tissue coverage may be beneficial when circumstances permit. NPWT may be useful when reconstruction is not feasible within 72 h.
C1 [Qiu, Emily; Kurlander, David E.; Ghaznavi, Amir M.] Case Western Reserve Univ, Plast Surg, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University
RP Ghaznavi, AM (通讯作者)，11100 Euclid Ave, Cleveland, OH 44116 USA.
EM amirghaznavi@gmail.com
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NR 26
TC 39
Z9 48
U1 0
U2 3
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PY 2018
VL 52
IS 5
BP 259
EP 264
DI 10.1080/2000656X.2018.1470979
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA HD8ZX
UT WOS:000452850900001
PM 29966481
OA gold
DA 2026-07-24
ER
PT J
AU Horch, RE
   Braumann, C
   Dissemond, J
   Lehner, B
   Hirche, C
   Woeste, G
   Wozniak, G
   Wetzel-Roth, W
   Willy, C
AF Horch, Raymund E.
   Braumann, Chris
   Dissemond, Joachim
   Lehner, Burkhard
   Hirche, Christoph
   Woeste, Guido
   Wozniak, Gernot
   Wetzel-Roth, Walter
   Willy, Christian
TI Use of Negative Pressure Wound Therapy with Instillation and Dwell Time
   for Wound Treatment - Results of an Expert Consensus Conference
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Review
DE wound infection; wound healing; wound debridement; vacuum-associated
   closure (for) wound dressing; vacuum instillation
ID INFECTIOUS-DISEASES SOCIETY; ANTIMICROBIAL SOLUTIONS; PREVENTION;
   INJURIES; CARE; GUIDELINES; MORTALITY; AMERICA
AB Rinsing wounds with wound cleansing solutions has long been a recognised cornerstone in wound management as a means of removing cell debris and surface pathogens in wound exudates. In combination with surgical debridement and topical negative pressure wound therapy (NPWT), this can facilitate the intended progression from the inflammatory to the proliferative phase of wound healing. Procedures of topical negative pressure wound therapy with instillation and a defined exposure/dwell-time of topical solutions under cyclic compression and decompression with foam dressings (NPWTi-d) can remove cellular remnants and debris that may inhibit the heal-ing process. At the same time, it can aid in reducing the bacterial load in contaminated or infected wounds. Since this newer technique is now commercially available and increasingly widespread, recommendations for the proper use and clinical indications were developed by a panel of interdisciplinary experts in the course of a consensus meeting. Although the level of evidence from expert opinions is low, general guidelines for a safe and effective use of NPWTi-d can be worked out that can be of assistance to the clinician. The consensus recommendations derived from this meeting include the objectives of the treatment, the administration modalities of NPWTi-d, the indications for various wounds, including their contraindications, therapy settings, as well as the use of topical instillation solutions, volume and duration (dwell time) based on current scientific data, optimal treatment duration and future developments of the NPWTi-d.
C1 [Horch, Raymund E.] Univ Klinikum Erlangen, Plast & Handchirurg Klin, Krankenhausstr 12, D-91054 Erlangen, Germany.
   [Braumann, Chris] Katholisches Klinikum Bochum, Klin Allgemein & Viszeralchirurg, St Josef Hosp, Bochum, Germany.
   [Dissemond, Joachim] Univ Klinikum Essen, Klin & Poliklin Dermatol Venerol & Allergol, Essen, Germany.
   [Lehner, Burkhard] Sekt Orthopad Onkol, Heidelberg, Germany.
   [Lehner, Burkhard] Klin Orthopad & Unfallchirurg, Heidelberg, Germany.
   [Hirche, Christoph] Heidelberg Univ, Luftrettungs Zentrum Rettungshubschrauber Christo, Klin Unfallchirurg & Orthopad,Ruprecht Karls Univ, Klin Unfallchirurg,Berufsgenossenschaftl Unfallkl, Ludwigshafen, Germany.
   [Woeste, Guido] Agaplesion Elisabethenstift gGmbH, Allgemein & Viszeralchirurg, Darmstadt, Germany.
   [Wozniak, Gernot] Knappschaftskrankenhaus Bottrop GmbH, Klin Gefasschirurg, Bottrop, Germany.
   [Wetzel-Roth, Walter] Wertachkliniken KH Schwabmunchen, Chirurg & Gefasschirurg, Buchloe, Germany.
   [Willy, Christian] Bundeswehrkrankenhaus Berlin, Unfallchirurg, Berlin, Germany.
C3 University of Erlangen Nuremberg; Ruhr University Bochum; University of
   Duisburg Essen; Ruprecht Karls University Heidelberg
RP Horch, RE (通讯作者)，Univ Klinikum Erlangen, Plast & Handchirurg Klin, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@uk-erlangen.de
RI Dissemond, Joachim/AFG-0691-2022; Hirche, Christoph/GYA-4981-2022;
   Horch, Raymund/H-8128-2019; /AAA-9828-2021; /AAJ-3174-2021
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NR 45
TC 18
Z9 23
U1 0
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD DEC
PY 2018
VL 143
IS 6
BP 609
EP 616
DI 10.1055/a-0713-0517
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HD9DN
UT WOS:000452861200013
PM 30537781
DA 2026-07-24
ER
PT J
AU Chen, K
   Lin, JT
   Sun, SB
   Lin, J
   Kong, JZ
   Tian, NF
AF Chen, Kai
   Lin, Jin-ti
   Sun, Shuai-bo
   Lin, Jian
   Kong, Jian-zhong
   Tian, Nai-feng
TI Vacuum-assisted closure combined with a closed suction irrigation system
   for treating postoperative wound infections following posterior spinal
   internal fixation
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE CSIS; Postoperative wound infection; Spinal surgery; VAC; Debridement;
   Wound healing
ID NEGATIVE-PRESSURE; TISSUE DEFECTS; THERAPY; FUSION; MANAGEMENT;
   DRAINAGE; EFFICACY
AB BackgroundWound infections after posterior spinal surgery are a troublesome complication; patients are occasionally forced to remove the internal fixation device, which can lead to instability of the spine and injury to the spinal cord. The purpose of this study was to evaluate the efficacy of modified vacuum-assisted closure (VAC) for treating an early postoperative spinal wound infection.MethodsWe conducted a retrospective study of 18 patients with wound infections after posterior spinal surgery from 2014 to 2017 at a single tertiary center. All patients included in the study received modified VAC treatment (VAC combined with a closed suction irrigation system, CSIS) until the wound satisfied the secondary closure conditions. Detailed information was obtained from the medical records.ResultsWound size decreased significantly after 1week of the modified VAC treatment. Three patients were treated with VAC three times and one patient received the VAC treatment four times; the remaining patients received the VAC treatment twice. The patients had excellent wound beds after an average of 8days. The wound healed completely after an average of 17days, and the average hospital stay was 33days. There was no recurrence of infection at the 1-year follow-up.ConclusionsThis study demonstrates that VAC combined with a CSIS is a safe, reliable, and effective method to treat a wound infection after spinal surgery. This improved VAC procedure provides an excellent wound bed to facilitate wound healing and shorten the hospital stay.
C1 [Chen, Kai; Kong, Jian-zhong] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Chen, Kai; Kong, Jian-zhong] Wenzhou Med Univ, Yuying Childrens Hosp, Med Sch 2, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Chen, Kai; Lin, Jin-ti; Sun, Shuai-bo; Lin, Jian; Tian, Nai-feng] Wenzhou Med Univ, Affiliated Hosp 2, Dept Spine Surg, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Chen, Kai; Lin, Jin-ti; Sun, Shuai-bo; Lin, Jian; Tian, Nai-feng] Wenzhou Med Univ, Yuying Childrens Hosp, Med Sch 2, Zhejiang Spine Surg Ctr, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University; Wenzhou Medical University
RP Kong, JZ (通讯作者)，Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Kong, JZ (通讯作者)，Wenzhou Med Univ, Yuying Childrens Hosp, Med Sch 2, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Tian, NF (通讯作者)，Wenzhou Med Univ, Affiliated Hosp 2, Dept Spine Surg, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Tian, NF (通讯作者)，Wenzhou Med Univ, Yuying Childrens Hosp, Med Sch 2, Zhejiang Spine Surg Ctr, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
EM chenkai1809@163.com; jzkongfey@126.com; tiannaifeng@163.com
OI Chen, Kai/0000-0001-6850-1723
CR ABBEY DM, 1995, J SPINAL DISORD, V8, P278, DOI 10.1097/00002517-199508040-00003
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NR 28
TC 13
Z9 15
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD DEC 17
PY 2018
VL 13
AR 321
DI 10.1186/s13018-018-1024-6
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HE7IL
UT WOS:000453606900002
PM 30558614
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Costa, ML
   Achten, J
   Bruce, J
   Davis, S
   Hennings, S
   Willett, K
   Petrou, S
   Jeffery, S
   Griffin, D
   Parker, B
   Masters, J
   Lamb, SE
   Tutton, E
   Parsons, N
AF Costa, Matthew L.
   Achten, Juul
   Bruce, Julie
   Davis, Sonia
   Hennings, Susie
   Willett, Keith
   Petrou, Stavros
   Jeffery, Steven
   Griffin, Damian
   Parker, Ben
   Masters, James
   Lamb, Sarah E.
   Tutton, Elizabeth
   Parsons, Nick
TI Negative-pressure wound therapy versus standard dressings for adults
   with an open lower limb fracture: the WOLLF RCT
SO HEALTH TECHNOLOGY ASSESSMENT
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COST-EFFECTIVENESS ANALYSIS; PATIENTS
   EXPERIENCES; RANDOMIZED-TRIAL; HEALTH; CARE; RECOVERY; PATIENT; TRAUMA;
   PAIN
AB Background: Open fractures of the lower limb occur when a broken bone penetrates the skin and is exposed to the outside environment. These are life-changing injuries. The risk of deep infection may be as high as 27%. The type of dressing applied after surgical debridement could potentially reduce the risk of infection in the open-fracture wound.
   Objectives: To assess the disability, rate of deep infection, quality of life and resource use in patients with severe open fracture of the lower limb treated with negative-pressure wound therapy (NPWT) versus standard wound management after the first surgical debridement of the wound.
   Design: A pragmatic, multicentre randomised controlled trial.
   Setting: Twenty-four specialist trauma hospitals in the UK Major Trauma Network.
   Participants: A total of 460 patients aged >= 16 years with a severe open fracture of the lower limb were recruited from July 2012 through to December 2015. Patients were excluded if they presented more than 72 hours after their injury or were unable to complete questionnaires.
   Interventions: Negative-pressure wound therapy (n = 226) where an 'open-cell' solid foam or gauze was placed over the surface of the wound and connected to a suction pump which created a partial vacuum over the dressing versus standard dressings not involving negative pressure (n = 234).
   Main outcome measures: Disability Rating Index (DRI) - a score of 0 (no disability) to 100 (completely disabled) at 12 months was the primary outcome measure, with a minimal clinically important difference of 8 points. The secondary outcomes were deep infection, quality of life and resource use collected at 3, 6, 9 and 12 months post randomisaton.
   Results: There was no evidence of a difference in the patients' DRI at 12 months. The mean DRI in the NPWT group was 45.5 points [standard deviation (SD) 28.0 points] versus 42.4 points (SD 24.2 points) in the standard dressing group, giving a difference of -3.9 points (95% confidence interval -8.9 to 1.2 points) in favour of standard dressings (p = 0.132). There was no difference in HRQoL and no difference in the number of surgical site infections or other complications at any point in the 12 months after surgery. NPWT did not reduce the cost of treatment and it was associated with a low probability of cost-effectiveness.
   Limitations: Owing to the emergency nature of the interventions, we anticipated that some patients who were randomised into the trial would subsequently be unable or unwilling to take part. Such post-randomisation withdrawal of patients could have posed a risk to the external validity of the trial. However, the great majority of these patients (85%) were found to be ineligible after randomisation. Therefore, we can be confident that the patients who took part were representative of the population with severe open fractures of the lower limb.
   Conclusions: Contrary to the existing literature and current clinical guidelines, NPWT dressings do not provide a clinical or an economic benefit for patients with an open fracture of the lower limb.
   Future work: Future work should investigate alternative strategies to reduce the incidence of infection and improve outcomes for patients with an open fracture of the lower limb. Two specific areas of potentially great benefit are (1) the use of topical antibiotic preparations in the open-fracture wound and (2) the role of orthopaedic implants with antimicrobial coatings when fixing the associated fracture.
C1 [Costa, Matthew L.; Achten, Juul; Bruce, Julie; Davis, Sonia; Hennings, Susie; Petrou, Stavros; Griffin, Damian; Parker, Ben; Lamb, Sarah E.; Parsons, Nick] Univ Warwick, Warwick Med Sch, Clin Trials Unit, Coventry, W Midlands, England.
   [Costa, Matthew L.; Griffin, Damian] Univ Hosp Coventry & Warwickshire NHS Trust, Coventry, W Midlands, England.
   [Costa, Matthew L.; Achten, Juul; Willett, Keith; Masters, James; Lamb, Sarah E.; Tutton, Elizabeth] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
   [Jeffery, Steven] Selly Oak Hosp, Birmingham, W Midlands, England.
C3 University of Warwick; University of Warwick; University of Oxford
RP Costa, ML (通讯作者)，Univ Warwick, Warwick Med Sch, Clin Trials Unit, Coventry, W Midlands, England.; Costa, ML (通讯作者)，Univ Hosp Coventry & Warwickshire NHS Trust, Coventry, W Midlands, England.; Costa, ML (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
EM Matthew.Costa@ndorms.ox.ac.uk
RI Petrou, Stavros/ABD-8323-2021; Masters, James/U-8764-2019; Parsons,
   Nick/AAA-8713-2019; Achten, Juul/KUD-8515-2024; Bruce,
   Julie/G-7588-2014; /A-5207-2013
OI Petrou, Stavros/0000-0003-3121-6050; Griffin,
   Damian/0000-0003-0952-7848; Costa, Matthew/0000-0003-3644-1388;
   Hennings, Susie/0000-0002-8160-6658; Masters, James/0000-0001-9663-8858;
   Parsons, Nick/0000-0001-9975-888X; Tutton,
   Elizabeth/0000-0003-3973-360X; Achten, Juul/0000-0002-8857-5743; Lamb,
   Sarah/0000-0003-4349-7195; Bruce, Julie/0000-0002-8462-7999; 
FU Medical Research Council [G0501681, G0700452] Funding Source: Medline;
   The Dunhill Medical Trust [DMT/RCS605] Funding Source: Medline;
   Department of Health [10/57/20] Funding Source: Medline; Economic and
   Social Research Council [1499410] Funding Source: researchfish; Medical
   Research Council [G0501681, G0700452] Funding Source: researchfish;
   National Institute for Health Research [NF-SI-0616-10103, 10/57/20]
   Funding Source: researchfish; The Dunhill Medical Trust [DMT/RCS605]
   Funding Source: researchfish; MRC [G0501681] Funding Source: UKRI
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   White IR, 2011, STAT MED, V30, P377, DOI 10.1002/sim.4067
   Willett K, 2016, HEALTH TECHNOL ASSES, V20, P1, DOI 10.3310/hta20750
   WILLIAMS A, 1990, HEALTH POLICY, V16, P199
   Wiseman T, 2016, INJURY, V47, P1983, DOI 10.1016/j.injury.2016.03.021
   Zhang TY, 2016, J FOOT ANKLE SURG, V55, P112, DOI 10.1053/j.jfas.2015.07.023
NR 100
TC 37
Z9 42
U1 0
U2 6
PU NIHR JOURNALS LIBRARY
PI SOUTHAMPTON
PA UNIV SOUTHAMPTON, EVALUATION, TRIALS & STUDIES COORDINATING CENTRE,
   ALPHA HOUSE, ENTERPRISE RD, SOUTHAMPTON, SO16 7NS, ENGLAND
SN 1366-5278
EI 2046-4924
J9 HEALTH TECHNOL ASSES
JI Health Technol. Assess.
PD DEC
PY 2018
VL 22
IS 73
BP 1
EP +
DI 10.3310/hta22730
PG 164
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA HE7MU
UT WOS:000453622600001
PM 30573002
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Al-Zahid, S
   Izadi, D
   Day, CJ
   Wilson, A
   Stone, C
   Smith, J
AF Al-Zahid, S.
   Izadi, D.
   Day, C. J.
   Wilson, A.
   Stone, C.
   Smith, J.
TI A novel airway management strategy for cervical necrotising fasciitis
   secondary to Bezold's abscess
SO ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
LA English
DT Article
DE Necrotising fasciitis; Mastoiditis; Tracheotomy; Permacol (TM); Negative
   pressure wound therapy
AB We describe a rare case of cervical necrotising fasciitis caused by mastoiditis and Bezold's abscess. This case was complicated by a tracheostomy delaying wound healing. A novel strategy to repair the tracheotomy defect using Permacol (TM), an acellular porcine dermal substitute, and a local muscle flap not previously reported in the literature is described to allow the use of negative pressure wound therapy dressing. This technique may be employed in similar applications for non-healing tracheotomy wounds.
C1 [Al-Zahid, S.; Izadi, D.; Day, C. J.; Wilson, A.; Stone, C.; Smith, J.] Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, England.
C3 University of Exeter
RP Al-Zahid, S (通讯作者)，Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, England.
EM saif.alzahid@gmail.com
CR Chen SJ, 2015, BRIT J ORAL MAX SURG, V53, P642, DOI 10.1016/j.bjoms.2015.04.017
   Krenk L, 2007, EUR ARCH OTO-RHINO-L, V264, P917, DOI 10.1007/s00405-007-0275-3
NR 2
TC 4
Z9 6
U1 0
U2 2
PU ROYAL COLL SURGEONS ENGLAND
PI LONDON
PA 35-43 LINCOLN'S INN FIELDS, LONDON WC2A 3PN, ENGLAND
SN 0035-8843
EI 1478-7083
J9 ANN ROY COLL SURG
JI Ann. R. Coll. Surg. Engl.
PD JAN
PY 2019
VL 101
IS 1
BP E23
EP E25
DI 10.1308/rcsann.2018.0181
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HF3KL
UT WOS:000454133800008
PM 30322284
OA Bronze
DA 2026-07-24
ER
PT J
AU Hermann, J
   Banasiewicz, T
   Kolodziejczak, B
AF Hermann, Jacek
   Banasiewicz, Tomasz
   Kolodziejczak, Barbara
TI Role of Vacuum-Assisted Closure in the Management of Crohn Anal Fistulas
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE anal fistula; Crohn disease; negative-pressure wound therapy; noncutting
   setons; vacuum-assisted closure; wound healing
ID THERAPY; DISEASE; INFLIXIMAB
AB BACKGROUND: Patients with Crohn disease-related anal fistulas are treated with debridement of fistulous tracts and the placement of noncutting setons (NCSs). However, to reduce the high recurrence rate, there is still a need to develop more effective treatment methods. OBJECTIVE: To compare NCS with vacuum-assisted closure (VAC) treatment. METHODS: Medical records of 47 patients with Crohn anal fistulas were retrospectively evaluated. They were divided into two groups (I, VAC; II, NCS), consisting of 24 and 23 patients, respectively. The fistulas in the former group were applied with VAC, whereas NCSs were placed in the latter group. Fistula healing was evaluated with the Fistula Drainage Assessment classification, Perianal Disease Activity Index, and the van Assche MRI-Based Score. RESULTS: There was a significant difference (P = .006) between the groups; closure of all fistulas at 6 months after treatment was achieved in 18 patients (75%) from group 1, compared with 8 patients (35%) from group 2. Partial response occurred in five patients (21%) from group 1 and in five patients (22%) from group 2. Closure of fistulous tracts was visualized via MRI in nine patients (37.50%) from group 1, more than twice as many patients as from group 2. CONCLUSIONS: Because preliminary results of the study showed a high rate of closure after application of VAC to Crohn anal fistulas, this method might be considered a novel sphincter-saving procedure.
C1 [Hermann, Jacek; Banasiewicz, Tomasz] Poznan Univ Med Sci, Dept Gen & Endocrine Surg & Gastroenterol Oncol, Poznan, Poland.
   [Kolodziejczak, Barbara] Poznan Univ Med Sci, Dept Comp Sci & Stat, Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences
RP Hermann, J (通讯作者)，Poznan Univ Med Sci, Dept Gen & Endocrine Surg & Gastroenterol Oncol, Poznan, Poland.
RI Kołodziejczak, Barbara/L-6136-2018
OI Kołodziejczak, Barbara/0000-0002-4182-4386
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Banasiewicz T, 2015, TECH COLOPROCTOL, V19, P173, DOI 10.1007/s10151-014-1247-4
   Banasiewicz T, 2015, NEGATIVE PRESSURE WO
   Chidi VN, 2015, EXPERT REV GASTROENT, V9, P797, DOI 10.1586/17474124.2015.1031110
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   WOLFF BG, 1985, DIS COLON RECTUM, V28, P709, DOI 10.1007/BF02560279
NR 14
TC 4
Z9 5
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2019
VL 32
IS 1
BP 35
EP 40
DI 10.1097/01.ASW.0000547411.16017.58
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA HF7GU
UT WOS:000454408400006
PM 30540570
DA 2026-07-24
ER
PT J
AU Chen, SJ
   Chen, YX
   Xiao, JR
   Wei, XZ
   Chen, SM
   Jiang, WZ
AF Chen, Shu-jun
   Chen, Yu-xuan
   Xiao, Jian-rui
   Wei, Xiao-zong
   Chen, Shuang-min
   Jiang, Wang-zhan
TI Negative Pressure Wound Therapy in Necrotizing Fasciitis of the Head and
   Neck
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FOURNIERS GANGRENE; MANAGEMENT
AB Purpose: Necrotizing fasciitis is a severe soft tissue infection that is uncommon in the head and neck region. Despite the advancement of care over the past few decades, the mortality rate remains high. Negative pressure wound therapy (NPWT), an advanced wound-healing technique, has become increasingly popular for a wide variety of complicated wounds. Since December 2015, we have used this technique in the management of necrotizing fasciitis of the head and neck. We report a consecutive case series treated with NPWT as the initial surgical procedure. Materials and
   Methods: Seven patients who received a surgical diagnosis of necrotizing fasciitis of the head and neck underwent surgery under general anesthesia. After complete debridement, an NPWT device was applied for positive drainage of the involved areas. The drainage tube was connected to a central negative pressure system. The device was not replaced or removed until the infection was controlled. Then, a conventional drainage approach was used.
   Results: Of the 7 patients, 6 underwent the surgical procedure and NPWT once; the remaining patient underwent these procedures twice. The infectious cavities showed a clean wound covered with healthy granulation formation during the removal of the NPWT device. The following course was uneventful. The mean time for wound healing was 17.3 +/- 6.1 days.
   Conclusions: NPWT provides various advantages compared with conventional debridement and drainage, resulting in excellent clinical outcomes. This method could be recommended as an alternative approach in the management of necrotizing fasciitis in the head and neck region. (C) 2018 American Association of Oral and Maxillofacial Suggeons
C1 [Chen, Shu-jun; Chen, Yu-xuan; Xiao, Jian-rui; Wei, Xiao-zong; Chen, Shuang-min; Jiang, Wang-zhan] 252nd Hosp Peoples Liberat Army China, Dept Oral & Maxillofacial Surg, 991 Baihuadong Rd, Baoding 071000, Peoples R China.
RP Chen, SJ (通讯作者)，252nd Hosp Peoples Liberat Army China, Dept Oral & Maxillofacial Surg, 991 Baihuadong Rd, Baoding 071000, Peoples R China.
EM shujunchen001@gmail.com
CR Angoules AG, 2007, INJURY, V38, pS19, DOI 10.1016/j.injury.2007.10.030
   [Anonymous], 2014, CURR PROB SURG, V51, P344, DOI 10.1067/j.cpsurg.2014.06.001
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NR 26
TC 25
Z9 31
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
EI 1531-5053
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD JAN
PY 2019
VL 77
IS 1
BP 87
EP 92
DI 10.1016/j.joms.2018.08.016
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA HF9BD
UT WOS:000454535400016
PM 30243707
DA 2026-07-24
ER
PT J
AU Li, TC
   Wang, QG
   Qin, Y
   Liu, YH
   Xiao, SF
AF Li, Tiancheng
   Wang, Quangui
   Qin, Yong
   Liu, Yuhe
   Xiao, Shuifang
TI A comparative study on effects of vacuum nasal drainage and nasal
   packing after septoplasty
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Correction of nasal septum deviation; vacuum sealing drainage; nasal
   packing
AB We studied the effects of vacuum sealing drainage (VSD) and nasal packing after correction of nasal septum deviation. One hundred and sixty patients treated by nasal septum deviation endoscopic correction were continuously selected and were randomly divided into control group (n = 80) and observation group (n = 80). The control group was treated with nasal packing using oil gauze or polymer hemostatic sponge. Patients enrolled in the observation group were treated with VSD and the treatment effects were compared. Results showed that post-operation visual analogue scale (VAS) values in the observation group were significantly lower than those in the control group. The measured degrees for nasal mucosa edema as well the incidence rate of complications were significantly lower than those in the control group. The total effective rate was significantly higher than that of the control group (P<0.05).
C1 [Li, Tiancheng; Wang, Quangui; Qin, Yong; Liu, Yuhe; Xiao, Shuifang] Peking Univ, Dept Otolaryngol Head & Neck Surg, Hosp 1, 8 Xishu Ku St, Beijing 100034, Peoples R China.
C3 Peking University
RP Xiao, SF (通讯作者)，Peking Univ, Dept Otolaryngol Head & Neck Surg, Hosp 1, 8 Xishu Ku St, Beijing 100034, Peoples R China.
EM shuifang_xiao87@yeah.net
RI li, tiancheng/HZJ-3490-2023; Wang, Quangui/ODM-0411-2025
CR Chamanga Edwin, 2016, Br J Community Nurs, VSuppl, pS6, DOI [10.12968/bjcn.2016.21.sup6.s6, 10.12968/bjcn.2016.21.Sup6.S6]
   Champagne C, 2016, EUR ANN OTORHINOLARY, V133, P167, DOI 10.1016/j.anorl.2016.01.002
   Dadaci M, 2016, J WOUND CARE, V25, P350, DOI 10.12968/jowc.2016.25.6.350
   Dai Baoqiang, 2014, Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V28, P118
   Dalgic A, 2016, J CRANIOFAC SURG, V27, pE487, DOI 10.1097/SCS.0000000000002805
   Farneti P, 2016, CLIN EXP OTORHINOLAR, V9, P131, DOI 10.21053/ceo.2015.00416
   Kara M, 2016, J CRANIOFAC SURG, V17, P156
   Kumar RD, 2016, INDIAN J OTOLARYNGOL, V68, P275, DOI 10.1007/s12070-015-0928-2
   Lin Wenbiao, 2015, Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V29, P2019
   Liu Hua, 2014, Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V28, P126
   Liu Wei, 2016, Zhonghua Shao Shang Za Zhi, V32, P356, DOI 10.3760/cma.j.issn.1009-2587.2016.06.011
   Liu YN, 2014, WORLD J SURG ONCOL, V12, DOI 10.1186/1477-7819-12-240
   Ozbal Koc Ayca E, 2016, Kulak Burun Bogaz Ihtis Derg, V26, P152, DOI [10.5606/kbbihtisas.2016.62444, 10.5606/kbbihtisas.2016.62444]
   Ren Huijun, 2014, Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V28, P1765
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   Wang Chunyan, 2015, Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V29, P448
NR 18
TC 2
Z9 2
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 12
BP 13787
EP 13791
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HF9FH
UT WOS:000454547200111
DA 2026-07-24
ER
PT J
AU Sun, D
   Qin, Y
   Chen, YJ
   Ju, WN
   Qi, BC
AF Sun, Di
   Qin, Ying
   Chen, Yujia
   Ju, Weina
   Qi, Baochang
TI Iliopsoas abscess formation as a complication of abdominal stab wound: a
   case report
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Abdominal injuries; stab wound; iliopsoas abscess; vacuum drainage;
   antibiotic
AB Stab wounds are commonly encountered in clinical practice. However, iliopsoas abscess formation after an abdominal stab wound is relatively rare and its treatment is not well-documented. We report a case of a 20-year-old man who developed an iliopsoas abscess 10 days after an abdominal stab wound. In collaboration with orthopedic surgeons, wound debridement was performed twice, followed by vacuum sealing drainage (VSD), and implantation of antibiotic-loaded bone cement beads. Abdominal CT performed one month after surgery showed resolution of the abscess and acceptable recovery. No recurrence of symptoms was observed thereafter. Interdisciplinary collaboration is important for surgical treatment of complicated stab wounds. Use of VSD and implantation of antibiotic bead chain was found effective in treating the iliopsoas abscess.
C1 [Sun, Di] Jilin Univ, Hosp 1, Dept Colorectal & Anal Surg, Changchun, Jilin, Peoples R China.
   [Qin, Ying] Jilin Univ, Hosp 1, Dept Neurosurg, Changchun, Jilin, Peoples R China.
   [Chen, Yujia] Jilin Univ, Hosp 1, Dept Gen Surg, Changchun, Jilin, Peoples R China.
   [Ju, Weina] Jilin Univ, Hosp 1, Dept Neurol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
   [Qi, Baochang] Jilin Univ, Hosp 1, Dept Orthopaed Traumatol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; Jilin University;
   Jilin University
RP Ju, WN (通讯作者)，Jilin Univ, Hosp 1, Dept Neurol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.; Qi, BC (通讯作者)，Jilin Univ, Hosp 1, Dept Orthopaed Traumatol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
EM erna198644@126.com; qibaochang1@163.com
RI chen, yujia/KJL-7313-2024
FU National Natural Science Foundation of China [81500911]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (No. 81500911).
CR Biffl WL, 2011, J TRAUMA, V71, P1494, DOI 10.1097/TA.0b013e31823ba1de
   Eder Frank, 2011, Pol Przegl Chir, V83, P117, DOI 10.2478/v10035-011-0019-3
   Hake ME, 2015, INJURY, V46, P1447, DOI 10.1016/j.injury.2015.05.008
   KLEMM K, 1979, ZBL CHIR, V104, P934
   Posacioglu H, 2009, TEX HEART I J, V36, P65
NR 5
TC 0
Z9 0
U1 0
U2 13
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 12
BP 13933
EP 13935
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HF9FH
UT WOS:000454547200135
DA 2026-07-24
ER
PT J
AU Curran, T
   Alvarez, D
   Del Valle, JP
   Cataldo, TE
   Poylin, V
   Nagle, D
AF Curran, T.
   Alvarez, D.
   Del Valle, J. Pastrana
   Cataldo, T. E.
   Poylin, V.
   Nagle, D.
TI Prophylactic closed-incision negative-pressure wound therapy is
   associated with decreased surgical site infection in high-risk
   colorectal surgery laparotomy wounds
SO COLORECTAL DISEASE
LA English
DT Article
DE Closed incision negative pressure therapy; surgical site infection;
   quality improvement
ID COST-MINIMIZATION ANALYSIS; AMERICAN-COLLEGE; READMISSION; STATISTICS;
   PREVENTION; TRIAL
AB Aim Surgical site infection in colorectal surgery is associated with significant healthcare costs, which may be reduced by using a closed-incision negative-pressure therapy device. The aim of this study was to assess the impact of closed-incision negative-pressure therapy on the incidence of surgical site infection. Method In this retrospective cohort study we evaluated all patients who had undergone high-risk open colorectal surgery at a single tertiary care centre from 2012 to 2016. We compared the incidence of surgical site infection between those receiving standard postoperative wound care between 2012 and 2014 and those receiving closed-incision negative-pressure therapy via a customizable device (Prevena Incision Management System, KCI, an Acelity company, San Antonio, Texas, USA) between 2014 and 2016. A validated surgical site infection risk score was used to create a 1:1 matched cohort subset. Results Negative pressure therapy was used in 77 patients and compared with 238 controls. Negative pressure patients were more likely to have a stoma (92% vs 48%, P < 0.01) and to be smokers (33% vs 15%, P < 0.01). Surgical site infection was higher in control patients (15%, n = 35/238) compared with negative pressure patients (7%, n = 5/77) (P = 0.05). On regression analysis, negative pressure therapy was associated with decreased surgical site infection (OR 0.27; 95% CI 0.09-0.78). These differences persisted in the matched analysis. Conclusion Negative pressure therapy was associated with decreased surgical site infection. Negative pressure therapy offers significant potential for quality improvement.
C1 [Curran, T.; Alvarez, D.; Del Valle, J. Pastrana; Cataldo, T. E.; Poylin, V.; Nagle, D.] Beth Israel Deaconess Med Ctr, Dept Surg, Div Colon & Rectal Surg, 330 Brookline Ave, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center
RP Curran, T (通讯作者)，30 Courtenay Dr,Suite 249 MSC 295, Charleston, SC 29425 USA.
EM thomascurran27@gmail.com
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   Shen P, 2017, J AM COLL SURGEONS, V224, P726, DOI 10.1016/j.jamcollsurg.2016.12.028
   Sutton E, 2017, J SURG RES, V207, P205, DOI 10.1016/j.jss.2016.08.082
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NR 36
TC 34
Z9 43
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JAN
PY 2019
VL 21
IS 1
BP 110
EP 118
DI 10.1111/codi.14350
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA HG1EP
UT WOS:000454693600016
PM 30047611
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Sogorski, A
   Lehnhardt, M
   Goertz, O
   Harati, K
   Kapalschinski, N
   Hirsch, T
   Daigeler, A
   Kolbenschlag, J
AF Sogorski, A.
   Lehnhardt, M.
   Goertz, O.
   Harati, K.
   Kapalschinski, N.
   Hirsch, T.
   Daigeler, A.
   Kolbenschlag, J.
TI Improvement of local microcirculation through intermittent Negative
   Pressure Wound Therapy (NPWT)
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Cutaneous microcirculation; Negative pressure wound therapy; NPWT;
   Tissue conditioning
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; LASER-DOPPLER;
   SHEAR-STRESS; ISCHEMIA; MECHANISMS; PERFUSION; PARADOX; INJURY; STATE
AB Background: Negative Pressure Wound Therapy (NPWT) is widely used across different kinds of surgical disciplines. A controversial debate was raised by diverging results from studies that were conducted to examine the impact of NPWT on local perfusion. Thus, there is a lack of evidence for one important underlying factors that influences the physiology of wound healing under an applied NPWT-dressing.
   Objective: To investigate the immediate local perfusion changes due to an applied intermittent NPWT protocol.
   Material and methods: A NPWT dressing was applied to the antero-lateral thigh of seven healthy volunteers with two probes of both pressure and microcirculatory measuring devices. One of each probe was placed under the NPWT dressing, the other one in close proximity next to it. A protocol consisting of two cycles of 10 min of -125 mmHg pressure, followed by 10 min of 0 mmHg pressure was applied. Measurements of local pressure to the underlying tissue, as well as microcirculatory changes were performed continuously.
   Results: Applied vacuum caused compressional forces (27.33 mmHg, p < 0.05) towards the underlying tissue. Blood Flow was increased after both suction periods (+52.5%, +108.7%; p < 0.05) and continued increasing until the end of measurements (+145.3%). This was accompanied by significant increase in Oxygen Saturation (+21.6%; p < 0.05) and Relative Hemoglobin Content (+16.7%). Red Blood Cell Velocity was found to be increased without statistical significance. Next to the dressing, changes were also significant but less pronounced.
   Conclusion: Intermittent NPWT improves local microcirculation with consecutive enhancement of oxygen supply.
C1 [Sogorski, A.; Lehnhardt, M.; Harati, K.; Kapalschinski, N.; Hirsch, T.] Ruhr Univ Bochum, BG Univ Hosp Bergmannsheil, Burn Ctr, Dept Plast Surg, Bochum, Germany.
   [Goertz, O.] Martin Luther Hosp, Dept Plast Reconstruct & Aesthet Surg, Hand Surg, Berlin, Germany.
   [Daigeler, A.; Kolbenschlag, J.] Eberhard Karl Univ, BG Trauma Ctr Tuebingen, Dept Hand Plast Reconstruct & Burn Surg, Schnarrenbergstr 95, D-72076 Tubingen, Germany.
C3 Ruhr University Bochum; Martin Luther University Halle Wittenberg;
   Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital
RP Kolbenschlag, J (通讯作者)，Eberhard Karl Univ, BG Trauma Ctr Tuebingen, Dept Hand Plast Reconstruct & Burn Surg, Schnarrenbergstr 95, D-72076 Tubingen, Germany.
EM Jonaskolbenschlag@gmail.com
RI Hirsch, Tobias/AAS-6707-2021; Daigeler, Adrien/C-9417-2016; Harati,
   Kamran/AHD-3426-2022
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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NR 31
TC 32
Z9 42
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-206X
J9 J TISSUE VIABILITY
JI J. Viab.
PD NOV
PY 2018
VL 27
IS 4
BP 267
EP 273
DI 10.1016/j.jtv.2018.08.004
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA HG4SR
UT WOS:000454965800014
PM 30121158
DA 2026-07-24
ER
PT J
AU Avino, A
   Jecan, CR
   Cozma, CN
   Stroescu, AEB
   Balan, DG
   Ionescu, D
   Mihai, A
   Tanase, M
   Raducu, L
AF Avino, Adelaida
   Jecan, Cristian Radu
   Cozma, Cristina Nicoleta
   Stroescu, Andra Elena Balcangiu
   Balan, Daniela Gabriela
   Ionescu, Dorin
   Mihai, Andrada
   Tanase, Mihaela
   Raducu, Laura
TI Negative Pressure Wound Therapy Using Polyurethane Foam in a Patient
   with Necrotizing Fasciitis
SO MATERIALE PLASTICE
LA English
DT Article
DE necrotinzing fasciitis; negative pressure; polyurethane foam; skin
   grafting
ID VACUUM-ASSISTED CLOSURE
AB Negative pressure wound therapy is one of the newest methods of treatment used in wound healing An important role of the system has a foam dressing that connects the wound with the vacuum. In general the sponge used in vacuum assisted therapies is made of polyurethane foam. We present the case of a 51-year-old male patient with a history of deep vein thrombosis (known for about 3 years) diagnosed with necrotizing fasciitis (NF). In this patient, after each step of the surgical treatment (large debridement and skin grafting) negative pressure wound therapy using polyurethane foam was used.
C1 [Avino, Adelaida; Jecan, Cristian Radu; Cozma, Cristina Nicoleta; Raducu, Laura] Prof Dr Agrippa Ionescu Clin Emergency Hosp, Dept Plast & Reconstruct Surg, 7 Ion Mincu Str, Bucharest 011356, Romania.
   [Jecan, Cristian Radu; Cozma, Cristina Nicoleta; Raducu, Laura] Carol Davila Univ Med & Pharm, Fac Med, Discipline Plast & Reconstruct Surg, 37 Dionisie Lupu Str, Bucharest 020021, Romania.
   [Stroescu, Andra Elena Balcangiu; Balan, Daniela Gabriela] Carol Davila Univ Med & Pharm, Fac Dent Med, Discipline Physiol, 37 Dionisie Lupu Str, Bucharest 020021, Romania.
   [Stroescu, Andra Elena Balcangiu] Emergency Univ Hosp Bucharest, Dept Dialysis, 169 Splaiul Independentei, Bucharest 050098, Romania.
   [Ionescu, Dorin] Carol Davila Univ Med & Pharm, Fac Med, Dept Med Semiol, Discipline Internal Med 1 & Nephrol, 37 Dionisie Lupu Str, Bucharest 020021, Romania.
   [Ionescu, Dorin] Emergency Univ Hosp Bucharest, 169 Splaiul Independentei, Bucharest 050098, Romania.
   [Mihai, Andrada] Univ Med & Pharm Carol Davila Bucharest, Fac Med, Discipline Diabet, Nutr & Metab Dis N Paulescu Natl Inst, 5-7 Ion Movila Str, Bucharest 030167, Romania.
   [Mihai, Andrada] Nutr & Metab Dis Prof N Paulescu, Dept Diabet 2, Nutr & Metab Dis Natl Inst Diabet, 5-7 Ion Movila Str, Bucharest 030167, Romania.
   [Tanase, Mihaela] Carol Davila Univ Med & Pharm, Fac Dent Med, Dept Pedodont, 37 Dionisie Lupu Str, Bucharest 020021, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy;
   Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy
RP Stroescu, AEB (通讯作者)，Carol Davila Univ Med & Pharm, Fac Dent Med, Discipline Physiol, 37 Dionisie Lupu Str, Bucharest 020021, Romania.; Stroescu, AEB (通讯作者)，Emergency Univ Hosp Bucharest, Dept Dialysis, 169 Splaiul Independentei, Bucharest 050098, Romania.
EM stroescu_andra@yahoo.com
RI Tanase, Mihaela/MDS-5244-2025; ionescu, dorin/AAD-6029-2020; Balan,
   Daniela-Gabriela/AAP-9322-2020; Raducu, Laura/AAS-4867-2021; Avino,
   Adelaida/AEW-1705-2022; /AAO-5229-2021; Andra-Elena,
   Balcangiu-Stroescu/AAY-8458-2021; /ADU-3815-2022; Mihai, Doina
   Andrada/JZT-5214-2024
OI ionescu, dorin/0000-0003-0411-6732; 
CR [Anonymous], 2014, CURR PROB SURG, V51, P344, DOI 10.1067/j.cpsurg.2014.06.001
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Duldner M, 2016, MATER PLAST, V53, P347
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NR 16
TC 9
Z9 10
U1 0
U2 7
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0025-5289
EI 2668-8220
J9 MATER PLAST
JI Mater. Plast.
PD DEC
PY 2018
VL 55
IS 4
BP 603
EP 605
PG 3
WC Materials Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA HG5AH
UT WOS:000454987400030
DA 2026-07-24
ER
PT J
AU Chu, WZ
   Liu, SD
   Wang, YB
   Li, JM
   Liu, HS
AF Chu, Wanzhong
   Liu, Shidong
   Wang, Yeben
   Li, Jianmin
   Liu, Huashui
TI Compressed Fixation Combined with Vacuum-Assisted Closure for Treating
   Acute Injury of the Heel Fat Pad
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE External Fixators; Heel; Negative-Pressure Wound Therapy; Replantation
ID ANATOMY; FOOT
AB Background: Treating acute injury of the heel fat pad is different from treating common soft tissue damage. Due to the paucity of literature on the topic, we described our initial experience treating acute injury of the heel fat pad to determine the ideal treatment method.
   Material/Methods: A total of 53 patients with acute injury of the heel fat pad admitted to our hospital were selected for the study and were randomly divided into 2 groups: the compressed fixation combined with vacuum-assisted closure group and the only reimplanted and sewn group. Twenty-seven of the heel fat pads were compressed and fixed using a flat, hard piece of plastic and hollow screws; then, they were covered with a vacuum-assisted closure device. The other 27 were only sewn without tension. The clinical results were evaluated according to the American Orthopedic Foot and Ankle Society hindfoot score and the British Medical Research Council function evaluation criteria
   Results: In the compressed fixation combined with vacuum-assisted closure group, flaps of 12 feet with retrograde avulsion injury survived successfully. Partial flap necrosis occurred in 8 feet. Seven feet underwent repair using the neurocutaneous vascular resupinated island flap. Results were excellent or good for 74% of patients according to the AOFS. However, in the only reimplanted and sewn group, results were excellent or good for 44% of patients according to the AOFS.
   Conclusions: Compressed fixation with vacuum-assisted closure is effective for treating acute injury of the heel fat pad, with high success rates and good utility.
C1 [Chu, Wanzhong; Liu, Shidong; Wang, Yeben; Liu, Huashui] Third Peoples Hosp Jinan, Dept Orthoped, Jinan, Shandong, Peoples R China.
   [Li, Jianmin] Shandong Univ, Qilu Hosp, Dept Orthopaed, Jinan, Shandong, Peoples R China.
C3 Shandong University
RP Li, JM (通讯作者)，Shandong Univ, Qilu Hosp, Dept Orthopaed, Jinan, Shandong, Peoples R China.
EM lijianmingk@163.com
RI Liu, Shidong/LUZ-1684-2024
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NR 16
TC 0
Z9 0
U1 0
U2 9
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD DEC 29
PY 2018
VL 24
BP 9466
EP 9472
DI 10.12659/MSM.910440
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HG6HH
UT WOS:000455081200003
PM 30593763
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Chotanaphuti, T
   Courtney, PM
   Fram, B
   den Kleef, NJI
   Kim, TK
   Kuo, FC
   Lustig, S
   Moojen, DJ
   Nijhof, M
   Oliashirazi, A
   Poolman, R
   Purtill, JJ
   Rapisarda, A
   Rivero-Boschert, S
   Veltman, ES
AF Chotanaphuti, Thanainit
   Courtney, Paul M.
   Fram, Brianna
   den Kleef, N. J. In
   Kim, Tae-Kyun
   Kuo, Feng-Chih
   Lustig, Sebastien
   Moojen, Dirk-Jan
   Nijhof, Marc
   Oliashirazi, Ali
   Poolman, Rudolf
   Purtill, James J.
   Rapisarda, Antony
   Rivero-Boschert, Salvador
   Veltman, Ewout S.
TI Hip and Knee Section, Treatment, Algorithm: Proceedings of International
   Consensus on Orthopedic Infections
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article; Proceedings Paper
CT 2nd International Consensus Meeting (ICM) on Musculoskeletal Infection
CY JUL 25-27, 2018
CL Philadelphia, PA
DE early postoperative infection; acute hematogenous infection; systemic
   sepsis; surgical bioburden reduction; persistent wound drainage;
   irrigation and debridement; surgical intervention; negative-pressure
   wound therapy; synovectomy; single-stage exchange; infected bilateral
   arthroplasties; infected bilateral hip arthroplasties; infected
   bilateral knee arthroplasties
ID PERIPROSTHETIC JOINT INFECTION; PRESSURE WOUND THERAPY; HEMATOGENOUS
   INFECTION; ARTHROPLASTY; DEBRIDEMENT; DRAINAGE; MALNUTRITION;
   COMPLICATION; REPLACEMENT; IRRIGATION
RI Poolman, Rudolf W/AAM-7815-2020; Kuo, Feng-Chih/W-3327-2019; Kim,
   Tae/AAG-1037-2021; Fram, Brianna/GSJ-0318-2022; Lustig,
   Sébastien/E-3375-2013
OI Poolman, Rudolf W/0000-0003-3178-2247; Kuo,
   Feng-Chih/0000-0001-5205-8333; Fram, Brianna/0000-0002-5888-3008; 
CR [Anonymous], 2013, BONE JOINT J, DOI [DOI 10.1002/JOR.22543, 10.1002/jor.22543]
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NR 56
TC 32
Z9 36
U1 0
U2 6
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD FEB
PY 2019
VL 34
IS 2
SU S
BP S393
EP S397
DI 10.1016/j.arth.2018.09.024
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics
GA HH1KC
UT WOS:000455477200046
PM 30348575
DA 2026-07-24
ER
PT J
AU Padalino, MA
   Carrozzini, M
   Vida, V
   Stellin, G
AF Padalino, Massimo A.
   Carrozzini, Massimiliano
   Vida, Vladimiro
   Stellin, Giovanni
TI Vacuum-Assisted Closure Therapy for the Treatment of Poststernotomy
   Wound Dehiscence in Neonates and Infants
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE chest wall; congenital heart disease; CHD; pediatric; wound healing;
   wound infection
AB We sought to analyze effectiveness and results of a vacuum-assisted closure system for the treatment of sternal wound dehiscence in newborns and children after cardiac surgery in our institution. Six patients with poststernotomy wound problems (large defects of epithelialization or mediastinitis) were treated with a vacuum-assisted closure (VAC) therapy. Median age was 5 months (range: 1-144); VAC therapy was started with negative pressure -75 mm Hg, continuously. All children achieved healing of the sternal wound and a subsequent closure after a median length of treatment of 8.3 days (range: 4-14). In conclusion, VAC therapy with high negative pressure is safe, effective, and is a well-tolerated therapy in pediatric patients with either early- or late poststernotomy wound dehiscence.
C1 [Padalino, Massimo A.; Carrozzini, Massimiliano; Vida, Vladimiro; Stellin, Giovanni] Univ Padua, Sch Med, Pediat & Congenital Cardiac Surg Unit, Dept Cardiac Thorac & Vasc Sci, Padua, Italy.
C3 University of Padua
RP Padalino, MA (通讯作者)，Ctr Gallucci, Pediat & Congenital Cardiac Surg Unit, Via Giustiniani 2, I-35128 Padua, Italy.
EM massimo.padalino@unipd.it
RI Vida, Vladimiro/F-3984-2012; Padalino, Massimo/J-8706-2018; Carrozzini,
   Massimiliano/M-7138-2018
OI Padalino, Massimo/0000-0002-7535-9670; STELLIN,
   GIOVANNI/0000-0002-1903-2542
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Filippelli S, 2015, J CARDIAC SURG, V30, P190, DOI 10.1111/jocs.12463
   Losanoff JE, 2002, EUR J CARDIO-THORAC, V21, P831, DOI 10.1016/S1010-7940(02)00124-0
   Tarzia V, 2014, INTERACT CARDIOV TH, V19, P70, DOI 10.1093/icvts/ivu101
   Ugaki S, 2010, INTERACT CARDIOV TH, V11, P247, DOI 10.1510/icvts.2010.235903
NR 5
TC 4
Z9 5
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD JAN
PY 2019
VL 67
IS 1
BP 55
EP 57
DI 10.1055/s-0037-1603933
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA HH1LR
UT WOS:000455481500010
PM 28628936
DA 2026-07-24
ER
PT J
AU Gopal, SV
   Solomon, A
AF Gopal, Sri Vengadesh
   Solomon, Ashley
TI An inexpensive method of negative pressure wound therapy for extremities
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure; therapy; wound
AB Negative pressure wound therapy (NPWT) is an established method for the faster wound healing of chronic non-healing wounds. It is also used for laparostomy wounds and healing of split skin grafts. The commercially available machine and the consumables for NPWT are very expensive and economically not feasible in developing and underdeveloped countries. So, we devised a NPWT system for wounds of the extremity using inexpensive, readily available materials in any hospital. The materials used are sterile glove, autoclaved sponge, Foley catheter, and a wall suction unit. The sponge was placed over the wound, and a sterile glove was pulled over it. A Foley catheter was placed over the sponge and taken out through one of the fingers of the glove. Adhesive plaster was used to air-seal the glove. The Foley catheter was fixed with silk ties and connected to wall suction. Granulation and wound healing was faster in this system. This system was safe and inexpensive for the treatment of wounds of the extremity.
C1 [Gopal, Sri Vengadesh; Solomon, Ashley] IGMCRI, Dept Gen Surg, Pondicherry 605009, India.
RP Gopal, SV (通讯作者)，IGMCRI, Dept Surg, Pondicherry 605009, India.
EM srivengadesh@gmail.com
CR Bui TD, 2006, AM J SURG, V192, P235, DOI 10.1016/j.amjsurg.2006.01.013
   Miller Christine, 2012, J Am Coll Clin Wound Spec, V4, P61, DOI 10.1016/j.jccw.2013.11.002
   Ruke M, 2013, J DIABETIC FOOT COMP, V5, P73
   Saraiya HA, 2013, ADV SKIN WOUND CARE, V26, P74, DOI 10.1097/01.ASW.0000426716.51702.29
   Sreelesh LS, 2017, INDIAN J SURG, V79, P81, DOI 10.1007/s12262-017-1589-z
NR 5
TC 4
Z9 6
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2019
VL 16
IS 1
BP 131
EP 133
DI 10.1111/iwj.13002
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA HH2FU
UT WOS:000455535100017
PM 30303310
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Jansen-Winkeln, B
   Niebisch, S
   Scheuermann, U
   Gockel, I
   Mehdorn, M
AF Jansen-Winkeln, Boris
   Niebisch, Stefan
   Scheuermann, Uwe
   Gockel, Ines
   Mehdorn, Matthias
TI Biomechanical Effects of Incisional Negative Wound Pressure Dressing: An
   Ex Vivo Model Using Human and Porcine Abdominal Walls
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID THERAPY
AB Introduction. Incisional negative pressure wound therapy (iNPWT) has been of recent interest in different surgical fields as beneficial outcomes on high-risk wounds have been reported. Nevertheless, its mechanisms of function are not widely studied to date. Methods. We established two ex vivo setups of iNPWT in porcine and human abdominal wall for measuring pressures within the wound which result from iNPWT application. For pressure measurements, a high-resolution manometry catheter and a balloon catheter probe were used in a wound sealed with either a commercially available PREVENA VAC kit or a self-made iNPWT kit. Furthermore, we evaluated seroma evacuation by iNPWT. Results. Both setups showed similar characteristics of pressure curves within the wound when applying increasing negative pressures. Application of high pressures did not result in a similar increase in wound pressure. Only subtotal evacuation of seroma by iNPWT application (about 75% of volume) could be detected. Conclusion. Our ex vivo model of iNPWT in porcine and human abdominal wall could show reproducible measurements of pressures within the wounds in both types of tissue. As intrawound pressures did not increase in the same way as the applied negative pressure, we suggest that our results do not advocate the idea of using iNPWT for wound care especially as seroma evacuation remains insufficient.
C1 [Jansen-Winkeln, Boris; Niebisch, Stefan; Scheuermann, Uwe; Gockel, Ines; Mehdorn, Matthias] Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Germany.
C3 Leipzig University
RP Jansen-Winkeln, B (通讯作者)，Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Germany.
EM boris.jansen-winkeln@medizin.uni-leipzig.de;
   stefan.niebisch@medizin.uni-leipzig.de;
   uwe.scheuermann@medizin.uni-leipzig.de;
   ines.gockel@medizin.uni-leipzig.de;
   matthias.mehdorn@medizin.uni-leipzig.de
RI Jansen-Winkeln, Boris/KPA-5791-2024
OI Jansen-Winkeln, Boris/0000-0002-3996-9391
FU German Research Foundation (DFG); Universitat Leipzig
FX The authors express their gratitude to the body donor for donating the
   corpse for their research project after passing away. The authors also
   thank their families for supporting their valuable decision. They
   acknowledge support from the German Research Foundation (DFG) and
   Universitat Leipzig within the program of Open Access Publishing.
CR Borgquist O, 2011, WOUND REPAIR REGEN, V19, P727, DOI 10.1111/j.1524-475X.2011.00741.x
   Kairinos N, 2010, J PLAST RECONSTR AES, V63, P174, DOI 10.1016/j.bjps.2008.08.037
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
   Karlakki SL, 2016, BONE JOINT RES, V5, P328, DOI 10.1302/2046-3758.58.BJR-2016-0022.R1
   Pachowsky M, 2012, INT ORTHOP, V36, P719, DOI 10.1007/s00264-011-1321-8
   Ranamukhaarachchi SA, 2016, SCI REP-UK, V6, DOI 10.1038/srep32074
   Scalise A, 2016, INT WOUND J, V13, P1260, DOI 10.1111/iwj.12492
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
NR 10
TC 11
Z9 13
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2018
VL 2018
AR 7058461
DI 10.1155/2018/7058461
PG 7
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA HH5BD
UT WOS:000455739800001
PM 30687756
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Steenkamp, CJ
   Kong, VY
   Bruce, JL
   Laing, GL
   Clarke, DL
AF Steenkamp, C. J.
   Kong, V. Y.
   Bruce, J. L.
   Laing, G. L.
   Clarke, D. L.
TI A selective vacuum assisted mesh mediated fascial traction approach
   following temporary abdominal containment for trauma laparotomy is
   effective in achieving closure
SO SOUTH AFRICAN JOURNAL OF SURGERY
LA English
DT Article
DE Vacuum assisted closure; Surgical Meshes; Occlusive dressings; Surgical
   Closure Techniques; Ventral hernia
ID OPEN ABDOMEN; PACK TECHNIQUE
AB Background: Definitive primary abdominal closure is often not possible nor desirable following trauma laparotomy. In such situations. temporary abdominal containment (TAC) is necessary. This audit reviews our experience with TAC and interrogates our use of the Vacuum Assisted Mesh Mediated Fascia' Traction approach (VAMMFT) to achieve delayed closure of the Open Abdomen (OA).
   Methods: We conducted a retrospective study over a 4-year period of trauma patients who underwent a trauma laparotomy and who required a TAC.
   Results: Over the four-year period. 596 patients underwent a laparotomy for trauma. Of these trauma laparotomies, 463 (78%) underwent primary closure and 133 (22%) required a TAC. Of these 133 patients who required a TAC, 37 died, 41 underwent delayed primary fascial closure at repeat laparotomy and 55 were left with an OA. Of this cohort of 55 patients. 15 underwent a VAMMFT procedure. The VAMMFT procedure yielded a 60% closure rate. with failure to close being clue to late mesh insertion and sepsis.
   Conclusion: Our initial results with VAMMFT are encouraging. The technique appears to be effective and safe. Ongoing audit will allow us to accrue more patients and to better refine our algorithms and strategies.
C1 [Steenkamp, C. J.; Kong, V. Y.; Bruce, J. L.; Laing, G. L.] Univ KwaZulu Natal, Dept Surg, Pietermaritzburg Metropolitan Trauma Serv, Durban, South Africa.
   [Clarke, D. L.] Univ Witwatersrand, Dept Surg, Johannesburg, South Africa.
C3 University of Kwazulu Natal; University of Witwatersrand
RP Steenkamp, CJ (通讯作者)，Univ KwaZulu Natal, Dept Surg, Pietermaritzburg Metropolitan Trauma Serv, Durban, South Africa.
EM christiensteenkamp@yahoo.co.uk
RI ; KONG, VICTOR/J-1762-2014; Laing, Grant/QJU-5653-2026
OI Kong, Victor/0000-0003-2291-2572; Clarke, Damian/0000-0002-8467-1455; 
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   BROCK WB, 1995, AM SURGEON, V61, P30
   Ghimenton F, 2000, BRIT J SURG, V87, P106, DOI 10.1046/j.1365-2168.2000.01337.x
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   Navsaria P, 2013, WORLD J EMERG SURG, V8, DOI 10.1186/1749-7922-8-4
   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   Quyn AJ, 2012, COLORECTAL DIS, V14, pE429, DOI 10.1111/j.1463-1318.2012.03045.x
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   WITTMANN DH, 1993, EUR J SURG, V159, P75
   WITTMANN DH, 1990, WORLD J SURG, V14, P218, DOI 10.1007/BF01664876
NR 14
TC 5
Z9 6
U1 0
U2 1
PU SA MEDICAL ASSOC
PI PRETORIA
PA BLOCK F CASTLE WALK CORPORATE PARK, NOSSOB STREET, ERASMUSKLOOF EXT3,
   PRETORIA, 0002, SOUTH AFRICA
SN 0038-2361
EI 2078-5151
J9 S AFR J SURG
JI South Afr. J. Surg.
PD DEC
PY 2018
VL 56
IS 4
BP 28
EP +
DI 10.17159/2078-5151/2018/v56n4a2674
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI0JU
UT WOS:000456128700006
OA gold
DA 2026-07-24
ER
PT J
AU Siebenbürger, G
   Grabein, B
   Schenck, T
   Kammerlander, C
   Böcker, W
   Zeckey, C
AF Siebenbuerger, G.
   Grabein, B.
   Schenck, T.
   Kammerlander, C.
   Boecker, W.
   Zeckey, C.
TI Eradication of Acinetobacter baumannii/Enterobacter
   cloacae complex in an open proximal tibial fracture and closed drop
   foot correction with a multidisciplinary approach using the Taylor
   Spatial Frame®: a case report
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Proximal tibial fracture; Locked plating; Open fracture; Acinetobacter
   baumannii; Complication; Outcome; Hexapod external fixation; Latissimus
   dorsi muscle flap; Antibiotics; Infection
ID ANTIBIOTIC-IMPREGNATED CEMENT; COLISTIN; CLASSIFICATION; OSTEOMYELITIS;
   MANAGEMENT; INFECTIONS; OUTCOMES; BEADS
AB BackgroundMulti-drug-resistant bacteria (e.g. Carbapenem-resistant Acinetobacter baumannii, extended-spectrum betalactamase or carbapenemase-producing enterobacteriaceae) are emerging in early-onset infections. So far, there is no report describing the eradication of these bacteria in a osseous infection of an open proximal tibial fracture in combination with the hexapod technology to address both osseous consolidation and closed drop foot correction.Case presentationAfter sustaining a proximal tibial fracture (Gustilo 3B), a 41-year-old man was primarily treated with open reduction and internal fixation by a locking plate and split-thickness skin graft in the home country. At the time of admission to our hospital there was a significant anterolateral soft tissue defect covered with an already-necrotic split-thickness graft and suspicious secretion. CAT and MRI scans revealed no signs of osseous healing, intramedullary distinctive osteomyelitis, as well as a large abscess zone in the dorsal compartment. Multiple wound smears showed multi-drug-resistant bacteria: Acinetobacter baumannii (Carbapenem resistant) as well as Enterobacter cloacae complex (AmpC overexpression). After implant removal, excessive osseous and intramedullary debridements using the Reamer Irrigator Aspirator (RIA((R))) as well as initial negative pressure wound therapy were performed. Colistin hand-modelled chains and sticks were applied topically as well as an adjusted systemic antibiotic scheme was applied. After repetitive surgical interventions, the smears showed bacterial eradication and the patient underwent soft tissue reconstruction with a free vascularized latissimus dorsi muscle flap. External fixation was converted to a hexapod fixator (TSF (R)) to correct primary varus displacement, axial assignment and secure osseous healing. A second ring was mounted to address the fixed drop foot in a closed fashion without further intervention. At final follow-up, 12months after trauma, the patient showed good functional recovery with osseous healing, intact soft tissue with satisfactory cosmetics and no signs of reinfection.ConclusionsA multidisciplinary approach with orthopaedic surgeons for debridement, planning and establishing osseous and joint correction and consolidation, plastic surgeons for microvascular muscle flaps for soft tissue defect coverage as well as clinical microbiologists for the optimized anti-infective treatment is essential in these challenging rare cases.Level of evidenceLevel IV.
C1 [Siebenbuerger, G.; Kammerlander, C.; Boecker, W.; Zeckey, C.] Ludwig Maximilians Univ Munchen, LMU Munich, Univ Hosp, Dept Gen Trauma & Reconstruct Surg, Marchioninistr 15, D-81377 Munich, Germany.
   [Grabein, B.] Ludwig Maximilians Univ Munchen, LMU Munich, Univ Hosp, Dept Clin Microbiol & Hosp Hyg, Marchioninistr 15, D-81377 Munich, Germany.
   [Schenck, T.] Ludwig Maximilians Univ Munchen, LMU Munich, Univ Hosp, Dept Hand Plast & Aesthet Surg, Nussbaumstr 20, D-80336 Munich, Germany.
C3 University of Munich; University of Munich; University of Munich
RP Zeckey, C (通讯作者)，Ludwig Maximilians Univ Munchen, LMU Munich, Univ Hosp, Dept Gen Trauma & Reconstruct Surg, Marchioninistr 15, D-81377 Munich, Germany.
EM Christian.Zeckey@med.uni-muenchen.de
RI Kammerlander, Christian/Z-2246-2019; /ADL-6367-2022
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NR 33
TC 8
Z9 12
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD JAN 19
PY 2019
VL 24
AR 2
DI 10.1186/s40001-019-0360-2
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HI1JW
UT WOS:000456202600001
PM 30660181
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ker, H
   Al-Murrani, A
   Rolfe, G
   Martin, R
AF Ker, Helen
   Al-Murrani, Abbas
   Rolfe, Gill
   Martin, Richard
TI WOUND Study: A Cost-Utility Analysis of Negative Pressure Wound Therapy
   After Split-Skin Grafting for Lower Limb Skin Cancer
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Negative pressure wound therapy; Economic evaluation; Cost-utility
   analysis; Skin cancer; Split skin grafting
ID ASSISTED CLOSURE DEVICE; BURDEN
AB Background: Skin cancer rates in New Zealand are estimated to be the highest in the world. Split-skin grafting is a common procedure after skin cancer excision in the lower limb. We sought to evaluate the cost-effectiveness of negative pressure wound therapy (NPWT) with same-day discharge in patients undergoing split-skin grafting of the lower limb for the treatment of skin cancer.
   Materials and methods: Using effectiveness and quality of life data from a blinded, randomized single-center trial, a decision analytic model was developed from the perspective of the New Zealand hospital health-care buyer. The patient population included adults aged >18 y undergoing elective removal of lower limb skin cancer who were deemed able to manage a portable negative pressure device at home. A deterministic cost-effectiveness model was constructed using cost and utility data from our single-center Wound outcomes in negative pressure dressing (WOUND) trial. Forty-nine patients were randomized to receive either a negative pressure dressing applied in theater with same-day discharge home or a traditional bolster dressing with 5 d of inpatient bed rest. Patients were followed up for 3 mo to assess the mean percentage of graft take and complications. Quality of life was assessed through a EuroQoL questionnaire at 5-7 d. Cost data were collected directly from hospital records for each patient. Probabilistic sensitivity analysis was used to characterize uncertainty.
   Results: Compared with standard dressing, NPWT resulted in an average cost saving of $3903.28 per treatment and a disutility of 0.083. At a willingness-to-pay threshold of 25,000 New Zealand dollars, the incremental net benefit is $1828.27, indicating that NPWT is a cost-effective treatment option. The probability of NPWT being cost-effective was 73.15%.
   Conclusions: NPWT and same-day discharge in the appropriately selected patient is a cost-effective treatment compared with standard care. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Ker, Helen; Rolfe, Gill; Martin, Richard] Waitemata Dist Hlth Board, Dept Surg, 124 Shakespeare Rd, Auckland 0622, New Zealand.
   [Al-Murrani, Abbas] Waitemata & Auckland DHB, Planning Funding & Outcomes, Auckland, New Zealand.
   [Martin, Richard] Melanoma Unit, Auckland, New Zealand.
RP Ker, H (通讯作者)，Waitemata Dist Hlth Board, Dept Surg, 124 Shakespeare Rd, Auckland 0622, New Zealand.
EM helen.ker@hotmail.com
FU Intermed
FX This research received funding from Intermed but the funder had no role
   in study design, data collection, analysis or publication.
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NR 20
TC 13
Z9 16
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAR
PY 2019
VL 235
BP 308
EP 314
DI 10.1016/j.jss.2018.10.016
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI9LL
UT WOS:000456777000041
PM 30691811
DA 2026-07-24
ER
PT J
AU Yuan, Y
   Niu, YH
   Xiao, WD
   Qi, BW
   Hu, X
   Yu, AX
AF Yuan, Ying
   Niu, Yahui
   Xiao, Weidong
   Qi, Baiwen
   Hu, Xiang
   Yu, Aixi
TI The Effect and Mechanism of Negative Pressure Wound Therapy on Lymphatic
   Leakage in Rabbits
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Lymphtic leakage; Lymphorrhea; Lymphocele; Negative pressure wound
   therapy; Rabbit; Animal model
ID INTERSTITIAL FLUID PRESSURE; VACUUM-ASSISTED CLOSURE; CHYLOUS ASCITES;
   COMPLICATIONS; MANAGEMENT; CHYLOTHORAX; CANCER; LYMPHORRHEA; DISSECTION;
   CHYLORRHEA
AB Background: Lymphatic leakage is one of the severe complications after lymphadenectomy. However, efficient treatment it still unclear.
   Materials and methods: We employed inguinal lymphadenectomy and saphenous lymphatic vessel excision to establish a inguinal lymphatic leakage rabbit model. Rabbits with bilateral lymphatic leakage were divided in two groups, which were subject to negative pressure wound therapy (NPWT) on right sides and dressing change on left sides, respectively. Following 7-11 d of treatment, skin thickness and drainage volume were measured. Western blot and RT-PCR were used for analyzing the VEGF-C level. Tissues of wound were dissected and subject to anti-LYVE-1 immunohistochemical for lymphatic average positive staining area percentage and the ratio of lymphatic lumen area evaluation.
   Results: Our lymphatic leakage model showed significant lymph stasis, delayed wound healing, and skin swelling and was confirmed by methylene blue instillation. Using this rabbit model, we found that NPWT could largely promote wound healing and resolution of skin edema. Compared with the dressing change group, the thickness of the dermis layer in the NPWT group was significantly reduced. Western blot and RT-PCR analysis showed a decrease of VEGF-C in the NPWT group. The immunohistochemical result of the NPWT group did not show a significant change in lymphatic average positive staining area percentage, whereas the ratio of lymphatic lumen area was significantly decreased, suggesting that NPWT treatment can significantly compress the dilated lymphatic vessels.
   Conclusions: We successfully established the first clinically relevant lymphatic leakage model in rabbits. NPWT can be an effective treatment for lymphatic leakage via reducing edema and lymphatic stasis by compressing dilated lymph vessels and promoting lymphatic drainage. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Yuan, Ying; Niu, Yahui; Xiao, Weidong; Qi, Baiwen; Hu, Xiang; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM yuaixi666@163.com
FU National Natural Science Foundation of China [81572163]
FX This work was supported by National Natural Science Foundation of China
   (grant number: 81572163).
CR Abai B, 2007, J VASC SURG, V45, P610, DOI 10.1016/j.jvs.2006.10.043
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NR 41
TC 12
Z9 17
U1 0
U2 19
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAR
PY 2019
VL 235
BP 329
EP 339
DI 10.1016/j.jss.2018.09.065
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI9LL
UT WOS:000456777000044
PM 30691814
DA 2026-07-24
ER
PT J
AU Santosa, KB
   Keller, M
   Olsen, MA
   Keane, AM
   Sears, ED
   Snyder-Warwick, AK
AF Santosa, Katherine B.
   Keller, Matt
   Olsen, Margaret A.
   Keane, Alexandra M.
   Sears, Erika D.
   Snyder-Warwick, Alison K.
TI Negative-Pressure Wound Therapy in Infants and Children: A
   Population-Based Study
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Negative-pressure wound therapy; Vacuum-assisted closure; Infants;
   Children; Adverse effects; Therapeutic use
ID VACUUM-ASSISTED CLOSURE; PEDIATRIC WOUNDS; MANAGEMENT; DRESSINGS
AB Background: Although the safety and benefits of negative-pressure wound therapy (NPWT) have been clearly demonstrated in the adult population, studies evaluating the safety and describing the use of NPWT in the pediatric population have been limited. Given this paucity, the goals of this study were to (1) evaluate the literature dedicated to NPWT use in infants and children and (2) leverage a population-level analysis to describe the experience of NPWT use in the pediatric population.
   Materials and methods: We performed a literature review and analyzed the Truven Health Analytics MarketScan Commercial Claims Databases from 2006 to 2014 to identify infants and children treated with NPWT. We evaluated patient characteristics, indications, complications before and after NPWT placement, and health care utilization within 30 d of NPWT placement.
   Results: We identified 457 articles, 11 of which fit our inclusion criteria. Most studies (65.2%) were case reports or series with less than 10 patients. In addition, we identified 3184 patients aged younger than of 18 y who were treated with NPWT between 2006 and 2014. Serious incident complications within 30 d after NPWT placement were rare (bleeding 0.6%, septicemia 0.5%, and sepsis 0.5%).
   Conclusions: Despite the lack of robust studies, NPWT is widely used for many indications and across different ages and providers. Given the low incidence of serious complications, we conclude that NPWT use in infants and children is safe and can be effectively used by different providers spanning surgical and nonsurgical disciplines. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Santosa, Katherine B.] Washington Univ, Sch Med, Dept Surg, Div Plast & Reconstruct Surg, 660 S Euclid Ave,Campus Box 8238, St Louis, MO 63110 USA.
   [Keller, Matt; Olsen, Margaret A.] Washington Univ, Div Infect Dis, Dept Internal Med, St Louis, MO USA.
   [Keane, Alexandra M.] Washington Univ, Sch Med, St Louis, MO USA.
   [Sears, Erika D.] Univ Michigan, Dept Surg, Sect Plast Surg, Ann Arbor, MI 48109 USA.
   [Snyder-Warwick, Alison K.] Washington Univ, Div Plast Surg, Dept Surg, St Louis, MO USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Washington
   University (WUSTL); University of Michigan System; University of
   Michigan; Washington University (WUSTL)
RP Snyder-Warwick, AK (通讯作者)，Washington Univ, Sch Med, Dept Surg, Div Plast & Reconstruct Surg, 660 S Euclid Ave,Campus Box 8238, St Louis, MO 63110 USA.
EM snydera@wustl.edu
OI Santosa, Katherine/0000-0002-6083-626X
FU Washington University Institute of Clinical and Translational Sciences
   from the National Center for Advancing Translational Sciences of the
   National Institutes of Health (NIH) [UL1TR002345]; National Institute of
   Neurological Disorders and Stroke (NINDS) [F32NS098561, K08NS096232];
   Center for Administrative Data Research; Washington University Institute
   of Clinical and Translational Sciences from the National Center for
   Advancing Translational Sciences of the NIH through the Agency for
   Healthcare Research and Quality [UL1TR002345, R24 HS19455]; Washington
   University Institute of Clinical and Translational Sciences from the
   National Center for Advancing Translational Sciences of the NIH through
   the National Cancer Institute at the NIH [UL1TR002345, KM1CA156708];
   National Center for Advancing Translational Sciences [UL1TR002345]
   Funding Source: NIH RePORTER
FX Research reported in this publication was supported by the Washington
   University Institute of Clinical and Translational Sciences grant
   UL1TR000448 from the National Center for Advancing Translational
   Sciences of the National Institutes of Health (NIH), and by the National
   Institute of Neurological Disorders and Stroke (NINDS) under Award
   Numbers F32NS098561 (to K.B.S.) and K08NS096232 (to A.K.S.W.).In
   addition, the work was supported by the Center for Administrative Data
   Research, which is supported in part by the Washington University
   Institute of Clinical and Translational Sciences grant UL1TR002345 from
   the National Center for Advancing Translational Sciences of the NIH,
   Grant Number R24 HS19455, through the Agency for Healthcare Research and
   Quality and Grant Number KM1CA156708 through the National Cancer
   Institute at the NIH.
CR Administration, 2009, UFAD FDA PREL PUBL H
   [Anonymous], 2011, ADM US FDA UPDATE SE
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NR 28
TC 20
Z9 28
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAR
PY 2019
VL 235
BP 560
EP 568
DI 10.1016/j.jss.2018.10.043
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI9LL
UT WOS:000456777000070
PM 30691843
DA 2026-07-24
ER
PT J
AU Egin, S
   Alemdar, A
   Saglam, F
   Güney, B
   Güven, H
AF Egin, Seracettin
   Alemdar, Ali
   Saglam, Fazil
   Guney, Burak
   Guven, Hakan
TI Treatment with vacuum-assisted closure system: A case of anastomotic
   leak after upper gastrointestinal surgery
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Anastomotic leak; oesophageal stent; open abdomen; vacuum assisted
   closure
ID MANAGEMENT
AB Presently described is a case treated via stent and vacuum-assisted closure (VAC). The patient developed an oesophagojejunostomy leak (OL) on the ninth postoperative day after a radical total gastrectomy.The patient was a 55-year-old male patient with adenocarcinoma localized to the small curvature on the corpus of the stomach. Relaparatomy was performed for the OL, including placement of an uncovered stent.The abdomen was washed 4 times.As the OL did not decrease, 2 covered stents (22 mm and 18 mm in diameter and 80 mm long) were inserted endoscopically.The OL continued to contaminate the abdomen. One tip of the VAC sponge was placed next to the anastomosis, and the other tip was removed from the left upper quadrant. Another VAC closure set was placed in the abdomen. Both VAC closures were connected to separate vacuum devices with 75 mmHg of pressure.VAC dressings were changed at regular intervals every 3 days, and these steps were repeated 7 times over 21 days.The covered stents were removed endoscopically in the final operation. Fistulography revealed that the OL was completely closed, and the VAC dressings were removed.The skin was closed by separating the subcutaneous oil layer of the fascia.VAC therapy can not only provide serious abdominal sepsis treatment and primary source control, but also accelerate granulation development and, in this case, quickly closed the anastomotic leakage.
C1 [Egin, Seracettin; Alemdar, Ali; Saglam, Fazil; Guney, Burak; Guven, Hakan] Univ Hlth Sci, Okmeydani Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
C3 University of Health Sciences Turkey; Istanbul Okmeydani Training &
   Research Hospital
RP Egin, S (通讯作者)，Saglik Bilimleri Univ, Okmeydani Egitim & Arastirma Hastanesi, Gen Cerrahi Klin, Istanbul, Turkey.
EM seracettin_egin@hotmail.com
RI Alemdar, Ali/HKV-6078-2023; Eğin, Seracettin/GQZ-0908-2022; Guney,
   Burak/NTR-0972-2025
CR Aurello P, 2015, AM SURGEON, V81, P450
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NR 8
TC 1
Z9 1
U1 0
U2 1
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD NOV
PY 2018
VL 24
IS 6
BP 601
EP 603
DI 10.5505/tjtes.2018.23238
PG 3
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA HJ3CB
UT WOS:000457046100018
PM 30516264
DA 2026-07-24
ER
PT J
AU Borys, S
   Ludwig-Slomczynska, AH
   Seweryn, M
   Hohendorff, J
   Koblik, T
   Machlowska, J
   Kiec-Wilk, B
   Wolkow, P
   Malecki, MT
AF Borys, S.
   Ludwig-Slomczynska, A. H.
   Seweryn, M.
   Hohendorff, J.
   Koblik, T.
   Machlowska, J.
   Kiec-Wilk, B.
   Wolkow, P.
   Malecki, Maciej T.
TI Negative pressure wound therapy in the treatment of diabetic foot ulcers
   may be mediated through differential gene expression
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Diabetic foot syndrome; Wound healing; NPWT; Gene expression
ID BINDING
AB AimsNegative pressure wound therapy (NPWT) has been successfully used as a treatment for diabetic foot ulceration (DFU). Its mechanism of action on the molecular level, however, is not fully understood. We assessed the effect of NPWT on gene expression in patients with type 2 diabetes (T2DM) and DFU.MethodsWe included two cohorts of patientsindividuals treated with either NPWT or standard therapy. The assignment to NWPT was non-randomized and based on wound characteristics. Differential gene expression profiling was performed using Illumina gene expression arrays and R Bioconductor pipelines based on the limma' package.ResultsThe final cohort encompassed 21 patients treated with NPWT and 8 with standard therapy. The groups were similar in terms of age (69.0 versus 67.5years) and duration of T2DM (14.5 versus 14.4years). We identified four genes differentially expressed between the two study arms post-treatment, but not pre-treatment: GFRA2 (GDNF family receptor alpha-2), C1QBP (complement C1q binding protein), RAB35 (member of RAS oncogene family) and SYNJ1 (synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1). Interestingly, all four genes seemed to be functionally involved in wound healing by influencing re-epithelialization and angiogenesis. Subsequently, we utilized co-expression analysis in publicly available RNA-seq data to reveal the molecular functions of GFRA2 and C1QBP, which appeared to be through direct protein-protein interactions.ConclusionsWe found initial evidence that the NPWT effect on DFUs may be mediated through differential gene expression. A discovery of the specific molecular mechanisms of NPWT is potentially valuable for its clinical application and development of new therapies.
C1 [Borys, S.; Hohendorff, J.; Kiec-Wilk, B.; Malecki, Maciej T.] Jagiellonian Univ, Dept Metab Dis, Coll Med, 15 Kopernika St, PL-31501 Krakow, Poland.
   [Borys, S.; Hohendorff, J.; Koblik, T.; Kiec-Wilk, B.; Malecki, Maciej T.] Univ Hosp, Krakow, Poland.
   [Ludwig-Slomczynska, A. H.; Seweryn, M.; Machlowska, J.; Wolkow, P.] Jagiellonian Univ, Ctr Med Genom OMICRON, Coll Med, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Malecki, MT (通讯作者)，Jagiellonian Univ, Dept Metab Dis, Coll Med, 15 Kopernika St, PL-31501 Krakow, Poland.; Malecki, MT (通讯作者)，Univ Hosp, Krakow, Poland.
EM malecki_malecki@yahoo.com
RI ; Seweryn, Michal/OEO-9216-2025; Wolkow, Pawel/AAI-4222-2021;
   Hohendorff, Jerzy/U-1857-2018
OI Ludwig-Słomczyńska, Agnieszka H/0000-0002-0548-4767; Machlowska,
   Julita/0000-0001-9951-9248; Seweryn, Michal/0000-0002-9090-3435; Wolkow,
   Pawel/0000-0002-9322-5545; Hohendorff, Jerzy/0000-0003-1153-8669
FU National Science Centre in Poland [2013/11/B/NZ5/03298]; European Union
   (7th Framework Programme) [286038]
FX The study was funded by the National Science Centre in Poland through
   251 the Opus Grant "Assessment of molecular mechanisms of negative
   pressure wound therapy in the treatment of neuropathic ulceration in
   diabetic foot syndrome" to MTM (Nr 2013/11/B/NZ5/03298). The Omicron
   laboratory (where the microarray experiments were performed) was funded
   by the European Union (7th Framework Programme, Call number
   FP7-REGPOT-2011-1, Grant number 286038).
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NR 20
TC 14
Z9 17
U1 0
U2 19
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JAN
PY 2019
VL 56
IS 1
BP 115
EP 120
DI 10.1007/s00592-018-1223-y
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HJ7OV
UT WOS:000457388100014
PM 30221321
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Simek, M
   Chudoba, A
   Hajek, R
   Tobbia, P
   Molitor, M
   Nemec, P
AF Simek, Martin
   Chudoba, Adam
   Hajek, Roman
   Tobbia, Patrick
   Molitor, Martin
   Nemec, Petr
TI From open packing to negative wound pressure therapy. A critical
   overview of deep sternal wound infection treatment strategies after
   cardiac surgery
SO BIOMEDICAL PAPERS-OLOMOUC
LA English
DT Article
DE sternal wound infection; conventional treatment; pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; C-REACTIVE
   PROTEIN; POSTSTERNOTOMY MEDIASTINITIS; MUSCLE FLAPS; CLOSED DRAINAGE;
   RISK-FACTORS; STERNOCUTANEOUS FISTULAS; ANTIBIOTIC IRRIGATION; SUCTION
   DRAINAGE
AB Deep sternal wound infection is a challenging aspect of modern cardiac surgery. The considerable mortality rate, devastating morbidity and, negative impact on long-term survival has driven cardiac and plastic surgeons to seek a more advantageous treatment solution.This review summarizes progress in the field of deep sternal wound infection treatment after cardiac surgery. Emphasis is placed on outcomes analysis of contemporary treatment strategy based on negative pressure wound therapy followed by sternotomy wound reconstruction, and its comparison with conventional treatment modalities used afore. Furthermore, complications and drawbacks of treatment strategies are critically evaluated to outline current options for successfully managing this life-threatening complication following cardiac surgery
C1 [Simek, Martin; Hajek, Roman] Univ Hosp Olomouc, Dept Cardiac Surg, Olomouc, Czech Republic.
   [Simek, Martin; Chudoba, Adam] Palacky Univ Olomouc, Fac Med & Dent, Olomouc, Czech Republic.
   [Tobbia, Patrick] Reg Med Ctr, Dept Cardiovasc Med, 624 Hosp Dr, Mt Home, AR USA.
   [Molitor, Martin] Hosp Na Bulovce, Dept Plast Surg, Prague, Czech Republic.
   [Nemec, Petr] Ctr Cardiovasc & Transplant Surg, Brno, Czech Republic.
C3 University Hospital Olomouc; Palacky University Olomouc; Bulovka
   University Hospital
RP Simek, M (通讯作者)，Univ Hosp Olomouc, Dept Cardiac Surg, Olomouc, Czech Republic.; Simek, M (通讯作者)，Palacky Univ Olomouc, Fac Med & Dent, Olomouc, Czech Republic.
EM martin.simek@c-mail.cz
RI ; /AAF-8445-2021; Hajek, Roman/AAB-4232-2020
OI Šimek, Martin/0000-0001-5377-2096; nemec, petr/0000-0002-4542-913X; 
FU MH CZ - DRO [00098892]
FX This work was supported by MH CZ - DRO (FNO1, 00098892).
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NR 91
TC 1
Z9 2
U1 0
U2 5
PU PALACKY UNIV, MEDICAL FAC
PI OLOMOUC
PA CENTRAL LIBRARY, HNEVOTINSKA 3, OLOMOUC, 00000, CZECH REPUBLIC
SN 1213-8118
EI 1804-7521
J9 BIOMED PAP
JI Biomed. Pap-Olomouc
PD DEC
PY 2018
VL 162
IS 4
BP 263
EP 271
DI 10.5507/bp.2018.053
PG 9
WC Engineering, Biomedical; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Research & Experimental Medicine
GA HJ8ZI
UT WOS:000457488200003
PM 30215435
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Godoy-Santos, AL
   Rosemberg, LA
   de Cesar-Netto, C
   Armstrong, DG
AF Godoy-Santos, Alexandre L.
   Rosemberg, Laercio A.
   de Cesar-Netto, Cesar
   Armstrong, David G.
TI The use of bioactive glass S53P4 in the treatment of an infected Charcot
   foot: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE bioglass; Charcot foot; osteomyelitis; preservation; principles of
   management
ID DIABETIC FOOT; AMPUTATION; OSTEOMYELITIS; COST; FATE; LEG
AB Objective: To report a case of successful limb-salvage staged treatment in the treatment of an infected diabetic Charcot foot.
   Case summary: A 45-year-old male with long-term, uncontrolled type 2 diabetes, six months' history of progressive deformity on the right foot and 45 days of purulent drainage in the lateral aspect of the foot. Patient was diagnosed with an infected Charcot foot with extensive midfoot bone involvement as shown by radiographic and MRI images. We used a multidisciplinary approach to treatment with early antibiotic therapy, tight glycaemic control and staged surgical treatment. Initial treatment was adequate irrigation and debridement, bone-void filling with bioactive glass, external fixation and provisional negative pressure wound therapy (NPWT). Later progressed to total contact casting and progressive protect weight bearing. At final follow-up, patient was full weight-bearing in stiff soled footwear, with no clinical signs of infection, no gross alteration of gait pattern and demonstrating complete bone healing and integration of the bioactive glass.
   Conclusion: The bioactive glass S53P4 was successfully used in the limb-salvage staged treatment of a patient with an infected Charcot foot. Here, full integration with the surrounding bone and its supportive action in the combat of bone infection was demonstrated.
C1 [Godoy-Santos, Alexandre L.] Hosp Israelita Albert Einstein, Dept Orthoped Surg, Sao Paulo, SP, Brazil.
   [Godoy-Santos, Alexandre L.; Rosemberg, Laercio A.] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Ortopedia & Traumatol, Sao Paulo, SP, Brazil.
   [Rosemberg, Laercio A.] Hosp Israelita Albert Einstein, Dept Radiol, Sao Paulo, SP, Brazil.
   [de Cesar-Netto, Cesar] Hosp Special Surg, Dept Orthoped Foot & Ankle, 535 E 70th St, New York, NY 10021 USA.
   [Armstrong, David G.] Univ Southern Calif, Southwestern Acad Limb Salvage Alliance, Keck Sch Med, Dept Surg, Los Angeles, CA USA.
C3 Hospital Israelita Albert Einstein; Universidade de Sao Paulo; Hospital
   Israelita Albert Einstein; University of Southern California
RP Godoy-Santos, AL (通讯作者)，Hosp Israelita Albert Einstein, Dept Orthoped Surg, Sao Paulo, SP, Brazil.; Godoy-Santos, AL (通讯作者)，Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Ortopedia & Traumatol, Sao Paulo, SP, Brazil.
EM alexandrelemegodoy@gmail.com
RI Godoy-Santos, Alexandre/F-7507-2016; de Cesar Netto, Cesar/D-3046-2018
OI Godoy-Santos, Alexandre/0000-0002-6672-1869; de Cesar Netto,
   Cesar/0000-0001-6037-0685
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NR 19
TC 10
Z9 12
U1 0
U2 10
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2019
VL 28
IS 1
SU S
BP S14
EP S17
DI 10.12968/jowc.2019.28.Sup1.S14
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HK3ZQ
UT WOS:000457858900003
PM 30724119
DA 2026-07-24
ER
PT J
AU Lau, NS
   Ahmadi, N
   Verran, D
AF Lau, Ngee-Soon
   Ahmadi, Nima
   Verran, Deborah
TI Abdominal wall complications following renal transplantation in adult
   recipients - factors associated with interventional management in one
   unit
SO BMC SURGERY
LA English
DT Article
DE Wound complications; Renal transplantation; Negative pressure wound
   therapy
ID PRESSURE WOUND THERAPY; SURGICAL SITE INFECTION; BODY-MASS INDEX;
   KIDNEY-TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; HEALING
   COMPLICATIONS; DIABETES-MELLITUS; RISK-FACTORS; OBESITY; INCISION
AB Background: Abdominal wall surgical site complications following renal transplantation can be challenging to manage. A sub-group of these recipients will require operative management or advanced wound care such as negative pressure wound therapy (NPWT). The aim of this study was to determine if there were any preoperative, intraoperative and postoperative characteristics in our recipients' cohort which were associated with the requirement for such interventions.
   Methods: A retrospective review of medical records was performed for all recipients who sustained abdominal wall complications following renal transplantation at our centre from 2006 to 2016.
   Results: A total of 64/828 recipients (7.7%) had abdominal wall complications. The mean weight for these patients was 84.9 kg (+/- 16.6 kg) and the mean body mass index was 30.2 (+/- 5.1). Forty-five recipients (70%) had a superficial wound dehiscence while nine (14%) had a complete fascial dehiscence. Operative intervention was required in 13/64 patients (20%) and was more likely to be required in the presence of a fascial dehiscence (9/9, 100%) or a wound collection (10/31, 32%) (p < 0.001, p = 0.021). NPWT was used in 17/64 patients (27%) and was more commonly required in patients with diabetes mellitus (10/24, 42%), a complete fascial dehiscence (5/9, 56%) or evidence of infection (16/44, 36%) (p = 0.039, p = 0.034, p = 0.008).
   Conclusions: The requirement for either operative management or the use of NPWT in the management of abdominal wall complications following renal transplantation in our experience was more common in recipients with diabetes mellitus, and in the setting of either complete fascial dehiscence, abdominal wall wound collections and/or infection.
C1 [Lau, Ngee-Soon; Ahmadi, Nima; Verran, Deborah] Royal Prince Alfred Hosp, Dept Transplant Surg, Sydney, NSW, Australia.
C3 NSW Health; Royal Prince Alfred Hospital; University of Sydney
RP Lau, NS (通讯作者)，Royal Prince Alfred Hosp, Dept Transplant Surg, Sydney, NSW, Australia.
EM ngeesoon.lau@health.nsw.gov.au
RI Verran, Deborah/V-3954-2019; Ahmadi, Nima/AAE-1158-2019
OI Ahmadi, Nima/0000-0003-0100-1200
CR ANZDATA Registry, 2014, INC END STAG KIDN DI
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   Australian Bureau of Statistics, 2014, NON TRADITIONAL REF
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NR 38
TC 15
Z9 17
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD JAN 21
PY 2019
VL 19
AR 10
DI 10.1186/s12893-019-0468-x
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HK5VD
UT WOS:000458035600001
PM 30665387
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Newman, JM
   Siqueira, MBP
   Klika, AK
   Molloy, RM
   Barsoum, WK
   Higuera, CA
AF Newman, Jared M.
   Siqueira, Marcelo B. P.
   Klika, Alison K.
   Molloy, Robert M.
   Barsoum, Wael K.
   Higuera, Carlos A.
TI Use of Closed Incisional Negative Pressure Wound Therapy After Revision
   Total Hip and Knee Arthroplasty in Patients at High Risk for Infection:
   A Prospective, Randomized Clinical Trial
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE revision; arthroplasty; wound healing; complications; infection;
   negative pressure wound therapy
ID SURGICAL SITE INFECTIONS; SHORT-TERM OUTCOMES; DRESSINGS; DRAINAGE;
   REPLACEMENT; SURGERY
AB Background: Continuous wound drainage after arthroplasty can lead to the development of a periprosthetic joint infection. Closed incisional negative pressure wound therapy (ciNPWT) has been reported to help alleviate drainage and other wound complications. The purpose of this prospective randomized controlled trial is to compare the use of ciNPWT with our standard of care dressing in revision arthroplasty patients who were at high risk to develop wound complications.
   Methods: A total of 160 patients undergoing elective revision arthroplasty were prospectively randomized to receive either ciNPWT or a silver-impregnated occlusive dressing after surgery in a single institution. Patients were included if they had at least 1 risk factor for developing wound complication(s): wound complication, readmission, and reoperation rates were collected at 2, 4, and 12 weeks postoperatively.
   Results: The postoperative wound complication rate was significantly higher in the control cohort compared to the ciNPWT cohort (19 [23.8%] vs 8 [10.1%], P = .022). There was no significant difference between the control and ciNPWT cohorts in terms of readmissions (19 [23.8%] vs 16 [20.3%], P = .595). Reoperation rate was higher in controls compared to ciNPWT patients (10 [12.5%] vs 2 [2.5%], P = .017). After adjusting for the history of a prior periprosthetic joint infection and inflammatory arthritis, the ciNPWT cohort had a significantly decreased wound complication rate (odds ratio 0.28, 95% confidence interval 0.11-0.68).
   Conclusion: ciNPWT may decrease the rate of postoperative wound complications in patients who are at an increased risk of such wound issues after revision arthroplasty. (C) 2019 The Authors. Published by Elsevier Inc.
C1 [Newman, Jared M.] Suny Downstate Med Ctr, Dept Orthopaed Surg, Brooklyn, NY 11203 USA.
   [Siqueira, Marcelo B. P.; Klika, Alison K.; Molloy, Robert M.] Cleveland Clin, Dept Orthopaed Surg, 9500 Euclid Ave A41, Cleveland, OH 44195 USA.
   [Barsoum, Wael K.; Higuera, Carlos A.] Cleveland Clin Florida, Dept Orthopaed Surg, Weston, FL USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; Cleveland Clinic Foundation; Cleveland Clinic
   Foundation
RP Klika, AK (通讯作者)，Cleveland Clin, Dept Orthopaed Surg, 9500 Euclid Ave A41, Cleveland, OH 44195 USA.
FU KCI/Acelity Inc. (San Antonio, TX)
FX This study was funded by a research grant provided by KCI/Acelity Inc.
   (San Antonio, TX).
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NR 39
TC 101
Z9 103
U1 0
U2 9
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD MAR
PY 2019
VL 34
IS 3
BP 554
EP +
DI 10.1016/j.arth.2018.11.017
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HL1ZF
UT WOS:000458502300029
PM 30545653
OA Bronze
DA 2026-07-24
ER
PT J
AU Kuncewitch, MP
   Blackham, AU
   Clark, CJ
   Dodson, RM
   Russell, GB
   Levine, EA
   Shen, P
AF Kuncewitch, Michael P.
   Blackham, Aaron U.
   Clark, Clancy J.
   Dodson, Rebecca M.
   Russell, Gregory B.
   Levine, Edward A.
   Shen, Perry
TI Effect of Negative Pressure Wound Therapy on Wound Complications
   Post-Pancreatectomy
SO AMERICAN SURGEON
LA English
DT Article
ID SURGICAL-SITE INFECTIONS; INTERNATIONAL STUDY-GROUP; INCISIONAL HERNIA;
   RISK; LAPAROTOMY; HOSPITALIZATION; DEFINITION; PREVENTION; IMPACT
AB Surgical site infection (SSI) and incisional hernia are common complications after major pancreatectomy. We investigated the effects of negative pressure wound therapy (NPWT) on short-and long-term wound outcomes in patients undergoing pan-createctomy. A randomized controlled trial comparing the effect of NPWT with standard surgical dressing (SSD) on wounds was performed in 265 patients undergoing open gastrointestinal resections from 2012 to 2016. We performed a subset analysis of 73 patients who underwent pancreatectomy. Wound complications in the first 30 days and incisional hernia rates were assessed. There were 33 (45%) female patients in the study and the average BMI was 27.6. The pancreaticoduodectomy rate was 68 per cent, whereas 27 per cent of patients underwent distal or subtotal pancreatectomy, and 4 per cent total pancreatectomy. Incisional hernia rates were 32 per cent and 14 per cent between the SSD and NPWT groups, respectively (P = 0.067). In the SSD (n = 37) and NPWT (n = 36) cohorts, the superficial SSI, deep SSI, seroma, and dehiscence rates were 16 per cent and 14 per cent (P > 0.99), 5 per cent and 8 per cent (P = 0.67), 16 per cent and 11 per cent (P = 0.74), and 5 per cent and 3 per cent (P >= 0.99), respectively. After adjusting for pancreatic fistula and delayed gastric emptying, no statistically significant differences in the primary outcomes were observed. These findings were true irrespective of the type of resection performed. Short- and long-term wound complications were not improved with NPWT. We observed a trend toward decreased incisional hernia rates in patients treated with NPWT. Owing to the multifactorial nature of wound complications, it is yet to be determined which cohorts of pancreatectomy patients will benefit from NPWT.
C1 [Kuncewitch, Michael P.; Clark, Clancy J.; Dodson, Rebecca M.; Levine, Edward A.; Shen, Perry] Wake Forest Univ, Bowman Gray Sch Med, Dept Gen Surg, Sect Surg Oncol,Wake Forest Baptist Med Ctr, Winston Salem, NC USA.
   [Blackham, Aaron U.] Lehigh Valley Phys Grp, Div Surg Oncol, Allentown, PA USA.
   [Russell, Gregory B.] Wake Forest Univ, Dept Biostat, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University
RP Shen, P (通讯作者)，Wake Forest Sch Med, Dept Gen Surg, Sect Surg Oncol, Watlington Hall,5th Floor, Winston Salem, NC 27157 USA.
EM pshen@wakehealth.edu
FU NCI NIH HHS [P30 CA012197] Funding Source: Medline; National Cancer
   Institute [P30CA012197] Funding Source: NIH RePORTER
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NR 27
TC 24
Z9 25
U1 0
U2 3
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JAN
PY 2019
VL 85
IS 1
BP 1
EP 7
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HL3OQ
UT WOS:000458625800024
PM 30760337
DA 2026-07-24
ER
PT J
AU Mir, A
   Guys, N
   Arianpour, K
   Svider, PF
   Rayess, H
   Zuliani, G
   Raza, SN
   Lin, HS
AF Mir, Ahsan
   Guys, Nicholas
   Arianpour, Khashayar
   Svider, Peter F.
   Rayess, Hani
   Zuliani, Giancarlo
   Raza, S. Naweed
   Lin, Hosheng
TI Negative Pressure Wound Therapy in the Head and Neck: An Evidence-Based
   Approach
SO LARYNGOSCOPE
LA English
DT Review
DE Negative pressure wound therapy; vacuum-assisted wound closure; head and
   neck; otolaryngology
ID VACUUM-ASSISTED CLOSURE; PHARYNGOCUTANEOUS FISTULA; MANAGEMENT;
   RECONSTRUCTION; DEVICE; COMPLICATIONS; DRESSINGS; SURGERY; REGION; FLAP
AB Objective To perform an evidence-based review with recommendations that evaluates the indications and utility of negative pressure wound therapy (NPWT) in the head and neck. Methods The authors searched the PubMed, Medline, Embase, Web of Science, and Cochrane Library databases for relevant literature. The primary outcome was successful intended use of NPWT, be it for granulation tissue formation, infection control, or complete wound closure. Patient demographics, etiology, and other clinical characteristics were explored. Meta-analysis of observational studies was used to examine response rates and wound sizes. Results Fifty-seven articles encompassing 522 patients were included. The most common etiologies reported included: neoplasm (343 patients [65.7%]), oro-/pharyngocutaneous fistula (9.8%), infection (10.5%), and trauma (9.6%). The majority of wounds treated were in the neck (61.6%). Potential risk factors that may compromise wound healing were noted in 217 of 522 patients (41.6%). Of these 217 patients, 135 had properly documented risk factors, with the most common being prior irradiation (63%). The overall mean response across studies was 85.7% (95% confidence interval: 0.806-0.896, P < 0.001, I-2 = 0 %). Conclusion Negative pressure wound therapy is useful for the management of head and neck wounds and should be considered for patients in whom wound healing is progressing insufficiently, including those with a history of head and neck cancer, oro-/pharyngocutaenous fistula, and trauma. Randomized controlled trials further comparing NPWT versus other modalities may be invaluable in further delineating its appropriate role. Laryngoscope, 129:671-683, 2019
C1 [Mir, Ahsan; Guys, Nicholas; Svider, Peter F.; Rayess, Hani; Zuliani, Giancarlo; Raza, S. Naweed; Lin, Hosheng] Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 4102 St Antoine,5E-UHC, Detroit, MI 48201 USA.
   [Zuliani, Giancarlo] Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Facial Plast & Reconstruct Surg, Detroit, MI USA.
   [Raza, S. Naweed; Lin, Hosheng] Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Inst, Detroit, MI USA.
   [Zuliani, Giancarlo; Raza, S. Naweed; Lin, Hosheng] John Dingell VA Med Ctr, Detroit, MI USA.
   [Arianpour, Khashayar] William Beaumont Hosp, Dept Otolaryngol, Royal Oak, MI 48072 USA.
C3 Wayne State University; Wayne State University; Barbara Ann Karmanos
   Cancer Institute; Wayne State University; Beaumont Health; Corewell
   Health William Beaumont University Hospital
RP Svider, PF (通讯作者)，Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 4102 St Antoine,5E-UHC, Detroit, MI 48201 USA.
EM psvider@gmail.com
RI Arianpour, Khashayar/S-1193-2019
OI Arianpour, Khashayar/0000-0002-4336-1776
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NR 69
TC 20
Z9 26
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD MAR
PY 2019
VL 129
IS 3
BP 671
EP 683
DI 10.1002/lary.27262
PG 13
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA HL7ML
UT WOS:000458925600032
PM 30134500
DA 2026-07-24
ER
PT J
AU Frear, CC
   Griffin, B
   Cuttle, L
   McPhail, SM
   Kimble, R
AF Frear, Cody C.
   Griffin, Bronwyn
   Cuttle, Leila
   McPhail, Steven M.
   Kimble, Roy
TI Study of negative pressure wound therapy as an adjunct treatment for
   acute burns in children (SONATA in C): protocol for a randomised
   controlled trial
SO TRIALS
LA English
DT Article
DE Paediatric; Burns; Negative-pressure Wound Therapy;
   Re-epithelialisation; Pain; Burn wound progression; Itch; Randomised
   controlled trial
ID VACUUM-ASSISTED CLOSURE; PARTIAL-THICKNESS BURNS; SCAR ASSESSMENT SCALE;
   PEDIATRIC BURNS; SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE; PAIN INTENSITY;
   CLINICAL-TRIAL; THERMAL-INJURY; MANAGEMENT
AB Although negative pressure wound therapy (NPWT) is widely used in the management of several wound types, its efficacy as a primary therapy for acute burns has not yet been adequately investigated, with research in the paediatric population particularly lacking. There is limited evidence, however, that NPWT might benefit children with burns, amongst whom scar formation, wound progression and pain continue to present major management challenges. The purpose of this trial is to determine whether NPWT in conjunction with standard therapy accelerates healing, reduces wound progression and decreases pain more effectively than standard treatment alone.
   A total of 104 children will be recruited for this trial. To be eligible, candidates must be under 17 years of age and present to the participating children's hospital within 7 days of their injury with a thermal burn covering < 5% of their total body surface area. Facial and trivial burns will be excluded. Following a randomised controlled parallel design, participants will be allocated to either an active control or intervention group. The former will receive standard therapy consisting of Acticoat (TM) and Mepitel (TM). The intervention arm will be treated with silver-impregnated dressings in addition to NPWT via the RENASYS TOUCH (TM) vacuum pump. Participants' dressings will be changed every 3 to 5 days until their wounds are fully re-epithelialised. Time to re-epithelialisation will be studied as the primary outcome. Secondary outcomes will include pain, pruritus, wound progression, health-care-resource use (and costs), ease of management, treatment satisfaction and adverse events. Wound fluid collected during NPWT will also be analysed to generate a proteomic profile of the burn microenvironment.
   The study will be the first randomised controlled trial to explore the clinical effects of NPWT on paediatric burns, with the aim of determining whether the therapy warrants implementation as an adjunct to standard burns management.
   Australian New Zealand Clinical Trials Registry, Registered on 16 February 2018.
C1 [Frear, Cody C.; Griffin, Bronwyn; Kimble, Roy] Univ Queensland, Ctr Childrens Burns & Trauma Res, Childrens Hlth Res Ctr, Level 7,62 Graham St, South Brisbane, Qld 4101, Australia.
   [Frear, Cody C.; Griffin, Bronwyn; Kimble, Roy] Queensland Childrens Hosp, Pegg Leditschke Childrens Burns Ctr, Lvl 5,501 Stanley St, South Brisbane, Qld 4101, Australia.
   [Frear, Cody C.; Griffin, Bronwyn; Kimble, Roy] Univ Queensland, Fac Med, 288 Herston Rd, Brisbane, Qld 4006, Australia.
   [Cuttle, Leila] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Ctr Childrens Burns & Trauma Res, Childrens Hlth Res Ctr, Lvl 8, South Brisbane, Qld 4101, Australia.
   [McPhail, Steven M.] Queensland Hlth, Metro South Hlth, Ctr Functioning & Hlth Res, Brisbane, Qld 4102, Australia.
   [McPhail, Steven M.] Queensland Univ Technol, Sch Publ Hlth & Social Work, Brisbane, Qld 4059, Australia.
   [McPhail, Steven M.] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia.
C3 University of Queensland; Childrens Health Queensland Hospital & Health
   Service; Queensland Childrens Hospital; University of Queensland;
   Queensland University of Technology (QUT); Queensland Health; Queensland
   University of Technology (QUT); Queensland University of Technology
   (QUT)
RP Frear, CC (通讯作者)，Univ Queensland, Ctr Childrens Burns & Trauma Res, Childrens Hlth Res Ctr, Level 7,62 Graham St, South Brisbane, Qld 4101, Australia.; Frear, CC (通讯作者)，Queensland Childrens Hosp, Pegg Leditschke Childrens Burns Ctr, Lvl 5,501 Stanley St, South Brisbane, Qld 4101, Australia.
EM cody.frear@uqconnect.edu.au
RI Cuttle, Leila/U-9376-2017; McPhail, Steven/JMR-2141-2023; Kimble,
   Roy/B-4160-2011; Griffin, Bronwyn/AEB-6299-2022
OI Cuttle, Leila/0000-0002-2282-4815; McPhail, Steven/0000-0002-1463-662X;
   Frear, Cody/0000-0002-6011-2472; Griffin, Bronwyn/0000-0002-6182-9125
FU Smith Nephew; National Health and Medical Research Council (Australian
   government) fellowship
FX Funding for this study has been provided by Smith & Nephew in the form
   of a research grant awarded to the Queensland University of Technology.
   Smith & Nephew's contact details: Namal Nawana (CEO), London, United
   Kingdom and Kingston upon Hull, United Kingdom. SMM is supported by a
   National Health and Medical Research Council (Australian government)
   fellowship.
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   ,, 2008, The global burden of disease: 2004 update
NR 142
TC 14
Z9 18
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD FEB 13
PY 2019
VL 20
AR 130
DI 10.1186/s13063-019-3223-9
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA HL7OC
UT WOS:000458929900003
PM 30760332
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Eckstein, FM
   Pinsel, V
   Wurm, MC
   Wilkerling, A
   Dietrich, EM
   Kreissel, S
   von Wilmowsky, C
   Schlittenbauer, T
AF Eckstein, Fabian Matthias
   Pinsel, Valesca
   Wurm, Matthias Christian
   Wilkerling, Andre
   Dietrich, Eva-Maria
   Kreissel, Sebastian
   von Wilmowsky, Cornelius
   Schlittenbauer, Tilo
TI Antiseptic negative pressure instillation therapy for the treatment of
   septic wound healing deficits in oral and maxillofacial surgery
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Negative pressure wound therapy; VAC; Head and neck; Wound healing
   deficits; Osteoradionecrosis of the jaw; Septic diseases of the jaw
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; MANAGEMENT; HEAD
AB Introduction: Impaired wound healing, chronic wounds and extended soft tissue defects present a crucial problem in reconstructive surgery of the head and neck region, even more after radiation therapy. In such cases the standard is a prolonged open wound treatment. The negative pressure instillation therapy might present an alternative therapy option.
   Material and methods: In this study the effects of negative pressure instillation therapy on the healing of chronic wounds in 15 patients diagnosed with impaired wound healing were investigated. These based upon infected osteoradionecrosis and osteomyelitis of the jaw. The parameters investigated as markers of the therapeutic success were serum inflammatory parameters i.e. white blood cell counts, wound smear results and wound surface reduction.
   Results: The use of negative pressure instillation therapy lead to a reduction of the bacterial load and formation of a stabile granulation tissue in all but one case. The mean inpatient time of the patients was 13.33 +/- 4.62 days. Between 2 and 8 dressing changes were needed to reach clinical sufficient wound healing results. Secondary intention wound healing could be obtained in 14 out of 15 cases. The crucial part for the successful application was a watertight enoral suturing as oro-cutaneous fistulae were present in most cases.
   Conclusion: The negative pressure instillation therapy poses a good treatment for wound healing problems and extended size soft tissue defects, even when oro-cutaneous fistulae were present. Especially in cases that contraindicate micro-vascular reconstruction, negative pressure instillation therapy could be a good alternative. (C) 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Eckstein, Fabian Matthias; Pinsel, Valesca; Wurm, Matthias Christian; Wilkerling, Andre; Dietrich, Eva-Maria; Kreissel, Sebastian; von Wilmowsky, Cornelius; Schlittenbauer, Tilo] Friedrich Alexander Univ Erlangen Nurnberg, Dept Oral & Maxillofacial Surg, Univ Hosp Erlangen, Gluckstr 11, D-91054 Erlangen, Germany.
   [Schlittenbauer, Tilo] Klinikum Augsburg Sud, Sect Oral & Maxillofacial Surg, Dept Otorhinolaryngol, D-86156 Augsburg, Germany.
C3 University of Erlangen Nuremberg; Klinikum Augsburg
RP Eckstein, FM (通讯作者)，Friedrich Alexander Univ Erlangen Nurnberg, Dept Oral & Maxillofacial Surg, Univ Hosp Erlangen, Gluckstr 11, D-91054 Erlangen, Germany.
EM Fabian.Eckstein@uk-erlangen.de
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
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NR 18
TC 11
Z9 13
U1 1
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD MAR
PY 2019
VL 47
IS 3
BP 389
EP 393
DI 10.1016/j.jcms.2018.12.006
PG 5
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA HM0HK
UT WOS:000459127800003
PM 30638743
DA 2026-07-24
ER
PT J
AU Onan, IS
   Yildiz, O
   Tüzün, B
   Timur, B
   Haydin, S
AF Onan, Ismihan Selen
   Yildiz, Okan
   Tuzun, Behzat
   Timur, Baris
   Haydin, Sertac
TI Vacuum-Assisted Closure for Mediastinitis in Pediatric Cardiac Surgery:
   A Single-Center Experience
SO ARTIFICIAL ORGANS
LA English
DT Article
DE Pediatric cardiac surgery; Mediastinitis; Treatment; Vacuum-assited
   closure; Congenital heart disease
ID NEGATIVE PRESSURES; THERAPY
AB Vacuum-assisted closure (VAC) has been widely used to treat mediastinitis after congenital cardiac surgery, which is associated with a high risk of morbidity and mortality. The aim in this study is to review our 14 cases of mediastinitis treated with VAC therapy after congenital cardiac surgery. We retrospectively reviewed the medical records of 14 congenital heart patients with mediastinitis from January 2012 to March 2017. Patients with fever, wound discharge, sternal dehiscence, a positive wound culture or abscess diagnosed with computed tomography are accepted as mediastinitis. A VAC was applied to all our patients without irrigation or dressing the wound because of sterility concerns. The vacuuming of the wound was either 50 mm Hg or 75 mm Hg according to the sternal intactness. We gradually decreased the pressures and changed the VAC systems once every three days, after wound healing was seen and a negative culture was obtained and VAC was terminated. There were 14 patients (8 male and 6 female) with mediastinitis and all of them were treated using VAC. The mean age of the patients was 6.96 months (ranging from 0.5-26 months). The mean weight was 5.16 kg (2.8-12 kg). Three patients needed extracorporeal membrane oxygenation after the surgery. Mean onset of mediastinitis was 25.3 days. The wound cultures showed methicillin resistant coagulase negative streptococcus and methicillin-sensitive staphylococcus aureus in most cases. Acinetobacter, serratia, pseudomonas, and klebsiella were the other bacterial species seen in cultures. Two patients had mediastinitis symptoms, but their cultures were negative. VAC systems were changed 3.85 times on average. Mean duration of hospital stay was 49.9 days (21-104 days). One patient needed a muscle flap to close the thoracic cavity after mediastinitis. Two patients did not survive. Mediastinitis is a serious postoperative condition in pediatric cardiac surgery patients. Classical wound dressing and irrigation methods are not suitable in mediastinitis for the pediatric age group. Therefore, VAC therapy can be an effective way to successfully treat the situation.
C1 [Onan, Ismihan Selen; Yildiz, Okan; Tuzun, Behzat; Timur, Baris; Haydin, Sertac] Istanbul SBU Mehmet Akif Ersoy Thorac & Cardiovas, Istanbul, Turkey.
C3 Mehmet Akif Ersoy Thoracic Cardiovascular Surgery Education Research
   Hospital
RP Onan, IS (通讯作者)，Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerra, Kalp Damar Cerrahi Anabilim Dali, TR-34303 Istanbul, Turkey.
EM selenibis@hotmail.com
RI Timur, Barış/KLD-2135-2024; tüzün, behzat/JZE-4500-2024
OI Timur, Barış/0000-0003-4446-6374; 
CR Aydin S, 2017, TURK GOGUS KALP DAMA, V25, P174, DOI 10.5606/tgkdc.dergisi.2017.13820
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NR 14
TC 10
Z9 12
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-564X
EI 1525-1594
J9 ARTIF ORGANS
JI Artif. Organs
PD FEB
PY 2019
VL 43
IS 2
SI SI
BP 119
EP 124
DI 10.1111/aor.13321
PG 6
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA HM0WI
UT WOS:000459167900003
PM 30281163
DA 2026-07-24
ER
PT J
AU Bellot, GL
   Dong, XK
   Lahiri, A
   Sebastin, SJ
   Batinic-Haberle, I
   Pervaiz, S
   Puhaindran, ME
AF Bellot, Gregory Lucien
   Dong, Xiaoke
   Lahiri, Amitabha
   Sebastin, Sandeep Jacob
   Batinic-Haberle, Ines
   Pervaiz, Shazib
   Puhaindran, Mark Edward
TI MnSOD is implicated in accelerated wound healing upon Negative Pressure
   Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants
   for wound management
SO REDOX BIOLOGY
LA English
DT Article
DE Negative pressure wound therapy; Skin wound healing; Manganese
   superoxide dismutase; MnSOD mimetics; MnTE-2-PyP5+
ID MANGANESE SUPEROXIDE-DISMUTASE; VACUUM-ASSISTED CLOSURE; GROWTH-FACTOR;
   EXPRESSION; ANGIOGENESIS; MECHANISMS; ENZYMES; TISSUE; OXYGEN
AB Negative Pressure Wound Therapy (NPWT), a widely used modality in the management of surgical and trauma wounds, offers clear benefits over conventional wound healing strategies. Despite the wide-ranging effects ascribed to NPWT, the precise molecular mechanisms underlying the accelerated healing supported by NPWT remains poorly understood. Notably, cellular redox status-a product of the balance between cellular reactive oxygen species (ROS) production and anti-oxidant defense systems-plays an important role in wound healing and dysregulation of redox homeostasis has a profound effect on wound healing. Here we investigated potential links between the use of NPWT and the regulation of antioxidant mechanisms. Using patient samples and a rodent model of acute injury, we observed a significant accumulation of MnSOD protein as well as higher enzymatic activity in tissues upon NPWT. As a proof of concept and to outline the important role of SOD activity in wound healing, we replaced NPWT by the topical application of a MnSOD mimetic, Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP5+, MnE, BMX-010, AEOI10113) in the rodent model. We observed that MnE is a potent wound healing enhancer as it appears to facilitate the formation of new tissue within the wound bed and consequently advances wound closure by two days, compared to the non-treated animals. Taken together, these results show for the first time a link between NPWT and regulation of antioxidant mechanism through the maintenance of MnSOD activity. Additionally this discovery outlined the potential role of MnSOD mimetics as topical agents enhancing wound healing.
C1 [Bellot, Gregory Lucien; Dong, Xiaoke; Lahiri, Amitabha; Sebastin, Sandeep Jacob; Puhaindran, Mark Edward] Natl Univ Hlth Syst, Univ Orthoped Hand & Reconstruct Microsurg Cluste, Dept Hand & Reconstruct Microsurg, Singapore, Singapore.
   [Bellot, Gregory Lucien; Pervaiz, Shazib] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore.
   [Pervaiz, Shazib] Natl Univ Singapore, Yong Loo Lin Sch Med, Med Sci Cluster Canc Program, Singapore, Singapore.
   [Batinic-Haberle, Ines] Duke Univ, Sch Med, Dept Radiat Oncol, Durham, NC USA.
   [Pervaiz, Shazib] Natl Univ Hlth Syst, Natl Univ Canc Inst, Singapore, Singapore.
   [Pervaiz, Shazib] Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore, Singapore.
   [Pervaiz, Shazib] Curtin Univ, Sch Pharm & Biomed Sci, Perth, WA, Australia.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; Duke University; National University
   of Singapore; National University of Singapore; Curtin University
RP Puhaindran, ME (通讯作者)，Natl Univ Hlth Syst, Univ Orthoped Hand & Reconstruct Microsurg Cluste, Dept Hand & Reconstruct Microsurg, Singapore, Singapore.; Pervaiz, S (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore.
EM phssp@nus.edu.sg; mark_e_puhaindran@nuhs.edu.sg
RI /E-7820-2010; Pervaiz, Shazib/C-4188-2015; Lahiri,
   Amitabha/AAH-7384-2021
FU National Medical Research Council, Singapore [NMRC/CNIG/1089/2012];
   National University Health System (NUHS) Bridging fund [NR15MRF023OM]
FX This work was supported by the National Medical Research Council,
   Singapore (grant number NMRC/CNIG/1089/2012) and National University
   Health System (NUHS) Bridging fund (grant number NR15MRF023OM).
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NR 58
TC 39
Z9 43
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD JAN
PY 2019
VL 20
BP 307
EP 320
DI 10.1016/j.redox.2018.10.014
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HM3GK
UT WOS:000459361500026
PM 30390545
OA gold
DA 2026-07-24
ER
PT J
AU Dhayat, SA
   Schacht, R
   Mennigen, R
   Palmes, D
   Vogel, T
   Vowinkel, T
   Senninger, N
   Laukoetter, MG
AF Dhayat, Sameer A.
   Schacht, Rosanna
   Mennigen, Rudolf
   Palmes, Daniel
   Vogel, Thomas
   Vowinkel, Thorsten
   Senninger, Norbert
   Laukoetter, Mike Georg
TI Long-Term Quality of Life Assessment After Successful Endoscopic Vacuum
   Therapy of Defects in the Upper Gastrointestinal Tract Quality of Life
   After EVT
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; Upper gastrointestinal tract;
   Anastomotic leakage; Quality of life
ID ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE; TREATMENT OPTIONS; MANAGEMENT;
   ESOPHAGECTOMY; PERFORATIONS; STENT; COMPLICATIONS; GASTRECTOMY
AB BackgroundAccumulating evidence indicates that anastomotic leakages and perforations of the upper gastrointestinal tract (uGIT) can be treated successfully with endoscopic vacuum therapy (EVT). So far, no data is available regarding the long-term quality of life (QoL) after successful EVT of defects in the uGIT.MethodsWe present a prospective survey on long-term Qol of 52 patients treated by EVT for defects of the uGIT. Results are compared with 63 of 221 patients treated by esophagectomy without anastomotic insufficiency (w/o EVT) between 12/2011 and 12/2015. The Gastrointestinal Quality of Life-Index (GIQLI) score was determined by a 36-item questionnaire of 25 respondents with EVT and 50 respondents w/o EVT.ResultsThe response rate was 78.95% (75/95) including 25 survey respondents who were treated with EVT for anastomotic insufficiency secondary to esophagectomy or gastrectomy (n=19), iatrogenic esophageal perforation (n=4), and Boerhaave syndrome (n=2) and 50 respondents with complication-free esophagectomy w/o EVT. The median follow-up was 19months for EVT patients and 21months for patients w/o EVT. Except for social function (p=0.009) in favor for patients w/o EVT, the median GIQLI score did not differ significantly between both study groups concerning the categories symptoms', emotions', physical functions', and medical treatment' resulting in a total median GIQLI score of 83 in EVT versus 96.5 in patients w/o EVT (p=0.185). Spearman Rho analysis revealed that a high GIQLI score correlated with a low ASA score (p<0.001), a benign pathology (p=0.001), and a hospital stay less than 21days (p<0.001).ConclusionEVT in the uGIT is well tolerated by the patients and accompanied by a satisfactory long-term QoL.
C1 [Dhayat, Sameer A.; Schacht, Rosanna; Mennigen, Rudolf; Palmes, Daniel; Vogel, Thomas; Vowinkel, Thorsten; Senninger, Norbert; Laukoetter, Mike Georg] Univ Hosp Muenster, Dept Gen & Visceral Surg, Albert Schweitzer Campus 1,Bldg W1, D-48149 Munster, Germany.
C3 University of Munster
RP Laukoetter, MG (通讯作者)，Univ Hosp Muenster, Dept Gen & Visceral Surg, Albert Schweitzer Campus 1,Bldg W1, D-48149 Munster, Germany.
EM laukoetter@uni-muenster.de
OI Dhayat, SA/0000-0002-5314-9736
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
   Alanezi Khaled, 2004, Ann Thorac Cardiovasc Surg, V10, P71
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   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Dasari BVM, 2014, ANN SURG, V259, P852, DOI 10.1097/SLA.0000000000000564
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   Weidenhagen R, 2010, ANN THORAC SURG, V90, P1674, DOI 10.1016/j.athoracsur.2010.07.007
NR 30
TC 11
Z9 16
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD FEB
PY 2019
VL 23
IS 2
BP 280
EP 287
DI 10.1007/s11605-018-4038-9
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA HM4UY
UT WOS:000459471700008
PM 30430432
DA 2026-07-24
ER
PT J
AU Svensson-Björk, R
   Zarrouk, M
   Asciutto, G
   Hasselmann, J
   Acosta, S
AF Svensson-Bjork, R.
   Zarrouk, M.
   Asciutto, G.
   Hasselmann, J.
   Acosta, S.
TI Meta-analysis of negative pressure wound therapy of closed groin
   incisions in arterial surgery
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT 32nd Annual Meeting of the European-Society-for-Vascular-Surgery (ESVS)
CY SEP 22-28, 2018
CL Valencia, SPAIN
SP Europ Soc Vasc Surg
ID SURGICAL-SITE INFECTIONS; RISK; COMPLICATIONS; PREVENTION; DRESSINGS;
   TRIALS
AB Background: Surgical-site infection (SSI) after groin incisions for arterial surgery is common and may lead to amputation or death. Incisional negative pressure wound therapy (NPWT) dressings have been suggested to reduce SSIs. The aim of this systematic review with meta-analysis was to assess the effects of incisional NPWT on the incidence of SSI in closed groin incisions after arterial surgery.
   Methods: A study protocol for this systematic review of RCTs was published in Prospero (CRD42018090298) a priori, with predefined search, inclusion and exclusion criteria. The records generated by the systematic research were screened for relevance by title and abstract and in full text by two of the authors independently. The selected articles were rated for bias according to the Cochrane risk-of-bias tool.
   Results: Among 1567 records generated by the search, seven RCTs were identified, including 1049 incisions. Meta-analysis showed a reduction in SSI with incisional NPWT (odds ratio (OR) 0.35, 95 per cent c.i. 0.24 to 0.50; P < 0.001). The heterogeneity between the included studies was low (I-2 = 0 per cent). The quality of evidence was graded as moderate. Two studies had multiple domains in the Cochrane risk-of-bias tool rated as high risk of bias. A subgroup meta-analysis of three studies of lower limb revascularization procedures only (363 incisions) demonstrated a similar reduction in SSI (OR 0.37, 0.22 to 0.63; P < 0.001; I-2 = 0 per cent).
   Conclusion: Incisional NPWT after groin incisions for arterial surgery reduced the incidence of SSI compared with standard wound dressings. The risk of bias highlighted the need for a high-quality RCT with cost-effectiveness analysis.
C1 [Svensson-Bjork, R.; Zarrouk, M.; Asciutto, G.; Hasselmann, J.; Acosta, S.] Skane Univ Hosp, Vasc Ctr, Malmo, Sweden.
   [Svensson-Bjork, R.; Zarrouk, M.; Asciutto, G.; Hasselmann, J.; Acosta, S.] Lund Univ, Dept Clin Sci, Ruth Lundskogs Gata 10, S-20502 Malmo, Sweden.
C3 Lund University; Skane University Hospital; Lund University
RP Svensson-Björk, R (通讯作者)，Lund Univ, Dept Clin Sci, Ruth Lundskogs Gata 10, S-20502 Malmo, Sweden.
EM robert.svensson_bjork@med.lu.se
RI Hasselmann, Julien/C-1586-2015; Hasselmann, Julien/C-1586-2015; Acosta,
   Stefan/JAX-3225-2023
OI Hasselmann, Julien/0000-0003-4453-0292; Svensson-Björk,
   Robert/0000-0003-1907-9022; Acosta, Stefan/0000-0002-3225-0798
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   [Anonymous], 2016, Global Guidelines for the Prevention of Surgical Site Infection
   [Anonymous], 26 C EUR WOUND MAN A
   [Anonymous], sing the risk of bias of individual studies in systematic
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NR 36
TC 39
Z9 41
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD MAR
PY 2019
VL 106
IS 4
BP 310
EP 318
DI 10.1002/bjs.11100
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA HM9KB
UT WOS:000459801800003
PM 30725478
OA Bronze
DA 2026-07-24
ER
PT J
AU Morinaga, K
   Rikimaru, Y
   Kiyokawa, K
AF Morinaga, Keigo
   Rikimaru, Yukiko
   Kiyokawa, Kensuke
TI Treatment of Abdominal Surgical Wound Dehiscence With Bowel Exposure and
   Infection Using Intrawound Continuous Negative Pressure, Irrigation, and
   Application of Artificial Dermis
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE abdominal surgical wound dehiscence; bowel exposure; intrawound
   continuous negative pressure and irrigation treatment; artificial dermis
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; MANAGEMENT; COMPLICATIONS;
   THERAPY
AB Abdominal surgical wound dehiscence with bowel exposure and infection carries a risk of intestinal fistula, making it extremely difficult to treat. The objective at this time is to heal such wounds safely and absolutely with using intrawound continuous negative pressure and irrigation treatment and artificial dermis. The subjects were 18 patients with abdominal wall dehiscence wounds with bowel exposure. Complications had already developed in 4 of the 18 cases of intestinal fistula. Subsequently, these 4 cases were treated with conservative treatment alone, whereas the other 14 were treated by split-thickness skin grafts. Intrawound continuous negative-pressure therapy has enabled the concomitant use of an artificial dermis inside the infected wound by maintaining irrigation of the wound. This method not only eliminated the danger of perforation from direct contact of the sponge with the bowel but also promoted the early proliferation of dermis-like tissue on the bowel surface, enabling safe and absolute healing.
C1 [Morinaga, Keigo; Rikimaru, Yukiko; Kiyokawa, Kensuke] Kurume Univ Hosp, Dept Plast & Reconstruct Surg & Maxillofacial Sur, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University
RP Kiyokawa, K (通讯作者)，Kurume Univ Hosp, Dept Plast & Reconstruct Surg & Maxillofacial Sur, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM prsmf@med.kurume-u.ac.jp
OI Rikimaru-Nishi, Yukiko/0009-0007-8486-2810
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NR 20
TC 5
Z9 7
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2019
VL 82
IS 2
BP 213
EP 217
DI 10.1097/SAP.0000000000001739
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HN0RJ
UT WOS:000459895800018
PM 30628933
DA 2026-07-24
ER
PT J
AU Deng, CL
   Yao, YZ
   Liu, ZY
   Li, H
   Yang, ZW
   Wang, DL
   Wei, ZR
AF Deng, Chengliang
   Yao, Yuanzhen
   Liu, Zhiyuan
   Li, Hai
   Yang, Zhaowei
   Wang, Dali
   Wei, Zairong
TI Chronic wound treatment with high-density nanofat grafting combined with
   negative pressure wound therapy
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Adipose-derived stem cells; nanofat; negative pressure wound therapy;
   stromal vascular fraction; wound healing
ID MESENCHYMAL STEM-CELLS; ADIPOSE-TISSUE; FAT; DIFFERENTIATION;
   REGENERATION; GEL
AB Negative pressure wound therapy is an essential technological advancement in wound care and stem cell therapy is the most promising treatment for chronic wounds. Nanofat grafting, an adipose-derived stem cell-based cytotherapy, has shown therapeutic potential for various conditions. However, the effects of negative pressure wound therapy combined with nanofat grafting on wound healing have not been investigated. In this study, high-density nanofat grafting combined with negative pressure wound therapy was used to treat patients with chronic wounds, while negative pressure wound therapy alone was used as the control. Data were analyzed with independent sample t-tests. A comparative study of wound healing rates, post-surgery, and histological changes revealed that average wound healing rates in the high-density nanofat combined with negative pressure wound therapy group were 26.50% +/- 9.51%, compared to 12.02% +/- 4.20% in the negative pressure wound therapy alone group. There were statistically significant differences (P < 0.01). Histological analysis using hematoxylin and eosin and Masson's trichrome staining, along with CD31 immunohistochemistry, showed less lymphocyte infiltration, greater collagen accumulation, and newly formed vessel growth in the high-density nanofat combined with negative pressure wound therapy group, compared with the control group. High-density nanofat grafting combined with negative pressure wound therapy is a safe and effective option, enhancing chronic wound healing.
C1 [Deng, Chengliang; Yao, Yuanzhen; Liu, Zhiyuan; Li, Hai; Yang, Zhaowei; Wang, Dali; Wei, Zairong] Zunyi Med Coll, Dept Plast Surg, Affiliated Hosp, 149 Dalian Rd, Zunyi 563000, Guizhou, Peoples R China.
C3 Zunyi Medical University
RP Wang, DL; Wei, ZR (通讯作者)，Zunyi Med Coll, Dept Plast Surg, Affiliated Hosp, 149 Dalian Rd, Zunyi 563000, Guizhou, Peoples R China.
EM daliwangzy@sina.com; zairong-wei@163.com
RI Yang, Zhaowei/D-1903-2009
FU National Nature Science Foundation of China [81660323]
FX This work was supported by the National Nature Science Foundation of
   China (81660323).
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   Sorice S, 2016, PLAST RECONSTR SURG, V138, p31S, DOI 10.1097/PRS.0000000000002646
   Spiekman M, 2017, J TISSUE ENG REGEN M, V11, P3220, DOI 10.1002/term.2213
   Tamburino S, 2016, ARCH PLAST SURG-APS, V43, P93, DOI 10.5999/aps.2016.43.1.93
   Tonnard P, 2013, PLAST RECONSTR SURG, V132, P1017, DOI 10.1097/PRS.0b013e31829fe1b0
   Ul Hassan W, 2014, WOUND REPAIR REGEN, V22, P313, DOI 10.1111/wrr.12173
   Vériter S, 2011, BIOMATERIALS, V32, P5945, DOI 10.1016/j.biomaterials.2011.02.061
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   Wu YJ, 2007, STEM CELLS, V25, P2648, DOI 10.1634/stemcells.2007-0226
   Yao Y, 2017, PLAST RECONSTR SURG, V139, P867, DOI 10.1097/PRS.0000000000003214
   Yoshimura K, 2008, TRANSPLANTATION, V85, P1868, DOI 10.1097/TP.0b013e3181775136
NR 31
TC 6
Z9 10
U1 0
U2 8
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 2
BP 1402
EP 1411
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HN2GB
UT WOS:000460002600009
DA 2026-07-24
ER
PT J
AU Jia, YC
   Shi, YH
AF Jia, Yanchun
   Shi, Yuhong
TI CLINICAL EXPLORATION OF VACUUM SEALING DRAINAGE IN WOUNDS OF SOFT TISSUE
   DEFECTS OF EXTREMITIES
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE VSD; soft tissue defects of extremities; clinical research
ID FLAP; THERAPY; ARTERY
AB Objective: The application of vacuum sealing drainage (VSD) nursing technology in wounds of soft tissue defects of extremities is discussed from various aspects. It seeks a nursing method that can prevent and reduce tube blockage, restore skin tissue, increase patient comfort, reduce treatment costs, and shorten hospital stay, and provide more ideal conditions for subsequent surgical treatment.
   Method: Patients were selected in Tangshan Gongren Hospital from June 2016 to June 2017 as subjects. Patients admitted to the hospital are randomly divided into four groups. Channel establishment and oxygen supply group (group 1): establish a negative pressure closed drainage channel and supply a local intermittent high concentration of oxygen; channel establishment group (group 2): establish a negative pressure closed drainage channel; oxygen supply group (group 3): supply negative pressure closed drainage intermittent high concentration oxygen; control group (group 4): routine care with simple negative pressure closed drainage. The differences and effects of each group in clogging the pipeline, restoring skin tissue, increasing patient comfort, reducing treatment costs, and shortening hospital stay are analyzed. Observe the response of the subjects after each experiment. That is, the number of cases of complications such as massive bleeding, post-debridement local infection, exposed bone and tendon degeneration, necrosis, and the number of cases in which no complications occurred during the treatment. The data of this experiment are statistically described and statistically inferred by SPSS17.0 software. The chi-square test is used to compare the count data, and the variance analysis test is used to compare the measurement data.
   Results: by comparison, channel establishment and oxygen supply group are superior to other groups in preventing and reducing tube blockage, restoring skin tissue, increasing patient comfort, reducing treatment costs, and shortening hospital stay.
   Conclusion: VSD care technology may be a new approach to the treatment of soft tissue defects of extremities. it has extensive clinical application value and promotion significance.
C1 [Jia, Yanchun] Tangshan Gongren Hosp, Community Med Care, Tangshan 063000, Peoples R China.
   [Shi, Yuhong] Tangshan Gongren Hosp, Dept Wound Treatment, 27 Wenhua Rd, Tangshan 063000, Peoples R China.
RP Shi, YH (通讯作者)，Tangshan Gongren Hosp, Dept Wound Treatment, 27 Wenhua Rd, Tangshan 063000, Peoples R China.
EM shiyuhongyh0@126.com
CR Aly E, 2017, INT J SURG, V37, pS312, DOI 10.1016/j.ijsu.2017.05.009
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   Kuehn F, 2017, SURG ENDOSC, V31, P1
   Kuehn F, 2016, J GASTROINTEST SURG, V20, P237, DOI 10.1007/s11605-015-3044-4
   Li H, 2017, Zhonghua Shao Shang Za Zhi, V33, P607, DOI 10.3760/cma.j.issn.1009-2587.2017.10.004
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NR 20
TC 0
Z9 0
U1 0
U2 10
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2019
VL 35
SI 1
BP 491
EP 498
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HN4CC
UT WOS:000460130800011
DA 2026-07-24
ER
PT J
AU Nguyen, T
   Rodriguez-Collazo, ER
AF Tea Nguyen
   Rodriguez-Collazo, Edgardo R.
TI Healing Heel Ulcers in High-Risk Patients: Distally Based Peroneus
   Brevis Muscle Flap Case Series
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE amputation prevention; calcaneus; limb salvage; orthoplastic; wound care
ID SOFT-TISSUE DEFECTS; LOWER LEG; FOOT; RECONSTRUCTION; COMPLICATIONS;
   ANKLE
AB The purpose of this study was to demonstrate use of a distally based peroneus brevis muscle flap in high-risk patients with diabetes and peripheral vascular disease for limb salvage of nonhealing heel ulcerations. Seventeen patients were referred for a below-knee amputation because of nonhealing heel ulcerations and peripheral vascular disease. As a last resort, 17 distally based peroneus brevis muscle flaps were elevated in 17 patients with full-thickness heel ulcerations measuring an average defect size of 14.11 cm2. All flaps were supplemented with concentrated bone marrow aspirate, negative pressure wound therapy, bilayer wound matrix, and static external fixation for an average time of 10.3 weeks. Split-thickness skin graft was delayed by an average of 17.5 days. All procedures were performed on patients diagnosed with diabetes, advanced peripheral arterial disease and a nonhealing heel ulcer present >1 year. All flaps survived at 1.5 years follow-up. The average time to healing was 10.3 weeks. No major amputations were performed to date. Partial tip necrosis occurred in 2 patients and healed uneventfully with local wound care. Distally based peroneus brevis muscle flaps in patients with diabetes and peripheral vascular disease offer a reliable alternative to limb salvage for full-thickness heel ulcerations measuring up to 7 x 6 cm. Combinatorial procedures are necessary to improve outcomes in high-risk patients whose alternative is a major amputation. Published by Elsevier Inc. on behalf of the American College of Foot and Ankle Surgeons.
C1 [Tea Nguyen] Watsonville Community Hosp, Dept Surg, Watsonville, CA USA.
   [Rodriguez-Collazo, Edgardo R.] Presence St Joseph Hosp, Dept Surg, Chicago, IL USA.
RP Nguyen, T (通讯作者)，9029 Soquel Ave,Suite D, Santa Cruz, CA 95062 USA.
EM teadpm@gmail.com
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NR 33
TC 12
Z9 13
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAR
PY 2019
VL 58
IS 2
BP 341
EP 346
DI 10.1053/j.jfas.2018.07.010
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA HN5JF
UT WOS:000460219700027
PM 30583837
DA 2026-07-24
ER
PT J
AU Hyldig, N
   Joergensen, JS
   Wu, C
   Bille, C
   Vinter, CA
   Sorensen, JA
   Mogensen, O
   Lamont, RF
   Möller, S
   Kruse, M
AF Hyldig, N.
   Joergensen, J. S.
   Wu, C.
   Bille, C.
   Vinter, C. A.
   Sorensen, J. A.
   Mogensen, O.
   Lamont, R. F.
   Moller, S.
   Kruse, M.
TI Cost-effectiveness of incisional negative pressure wound therapy
   compared with standard care after caesarean section in obese women: a
   trial-based economic evaluation
SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Article
DE Caesarean section; cost-effectiveness; economic evaluation; incisional
   negative pressure wound therapy; obesity; quality-adjusted life-years;
   surgical site infection
ID SURGICAL SITE INFECTION; RISK-FACTORS; METAANALYSIS; VACUUM
AB Objective To evaluate the cost-effectiveness of incisional negative pressure wound therapy (iNPWT) in preventing surgical site infection in obese women after caesarean section. Design A cost-effectiveness analysis conducted alongside a clinical trial. Setting Five obstetric departments in Denmark. Population Women with a pregestational body mass index (BMI) >= 30 kg/m(2). Method We used data from a randomised controlled trial of 876 obese women who underwent elective or emergency caesarean section and were subsequently treated with iNPWT (n = 432) or a standard dressing (n = 444). Costs were estimated using data from four Danish National Databases and analysed from a healthcare perspective with a time horizon of 3 months after birth. Main outcome measures Cost-effectiveness based on incremental cost per surgical site infection avoided and per quality-adjusted life-year (QALY) gained. Results The total healthcare costs per woman were euro5793.60 for iNPWT and euro5840.89 for standard dressings. Incisional NPWT was the dominant strategy because it was both less expensive and more effective; however, no statistically significant difference was found for costs or QALYs. At a willingness-to-pay threshold of euro30,000, the probability of the intervention being cost-effective was 92.8%. A subgroup analysis stratifying by BMI shows that the cost saving of the intervention was mainly driven by the benefit to women with a pre-pregnancy BMI >= 35 kg/m(2). Conclusion Incisional NPWT appears to be cost saving compared with standard dressings but this finding is not statistically significant. The cost savings were primarily found in women with a pre-pregnancy BMI >= 35 kg/m(2).
C1 [Hyldig, N.; Bille, C.; Sorensen, J. A.] Univ Southern Denmark, Inst Clin Res, Odense Univ Hosp, Dept Plast Surg, Odense, Denmark.
   [Hyldig, N.; Joergensen, J. S.; Wu, C.; Vinter, C. A.; Lamont, R. F.] Univ Southern Denmark, Inst Clin Res, Odense Univ Hosp, Dept Obstet & Gynaecol, Odense, Denmark.
   [Hyldig, N.; Moller, S.] Odense Univ Hosp, OPEN Odense Patient Data Explorat Network, Odense, Denmark.
   [Mogensen, O.] Karolinska Univ Hosp, Div Pelv Canc, Stockholm, Sweden.
   [Mogensen, O.] Karolinska Inst, Stockholm, Sweden.
   [Lamont, R. F.] UCL, Div Surg, London, England.
   [Moller, S.] Univ Southern Denmark, Dept Clin Res, Odense, Denmark.
   [Kruse, M.] Univ Southern Denmark, Dept Publ Hlth, Danish Ctr Hlth Econ DaCHE, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Odense University Hospital; Karolinska Institutet; Karolinska
   University Hospital; Karolinska Institutet; University of London;
   University College London; University of Southern Denmark; University of
   Southern Denmark
RP Hyldig, N (通讯作者)，Odense Univ Hosp, JB Winslows Vej 9 A,3 Floor, DK-5000 Odense C, Denmark.
EM nana.hyldig@rsyd.dk
RI Sørensen, Jens Ahm/D-6279-2014; Möller, Sören/X-8738-2019; Hyldig,
   Nana/AAH-5220-2020; Mogensen, Ole/Q-1894-2015
OI Sørensen, Jens Ahm/0000-0003-4903-0094; Möller,
   Sören/0000-0003-0858-4269; Hyldig, Nana/0000-0001-6758-6294; Mogensen,
   Ole/0000-0001-7655-9909; jørgensen, jan stener/0000-0001-5222-2535;
   Vinter, Christina Anne/0000-0001-5084-6053
FU University of Southern Denmark; Odense University Hospital; Region of
   Southern Denmark; Lundbeckfonden; iNPWT device manufacturer Smith
   Nephew; Steno Diabetes Center Odense (SDCO) [SDCO Research 002] Funding
   Source: researchfish
FX The RCT was funded by grants from the University of Southern Denmark,
   Odense University Hospital, the Region of Southern Denmark,
   Lundbeckfonden, and an unrestricted grant from the iNPWT device
   manufacturer Smith& Nephew. None of these sources of funds had influence
   on study design, data collection, data analyses, interpretation of
   results, or on the writing of the report.
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   Pedersen KM, 2003, VAERDISAETNING SUNDH
   Posnett J, 2009, J Wound Care, V18, P154
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NR 35
TC 34
Z9 37
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1470-0328
EI 1471-0528
J9 BJOG-INT J OBSTET GY
JI BJOG
PD APR
PY 2019
VL 126
IS 5
BP 619
EP 627
DI 10.1111/1471-0528.15573
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA HN7AY
UT WOS:000460341700015
PM 30507022
OA Green Accepted, Bronze
DA 2026-07-24
ER
PT J
AU Hyldig, N
   Vinter, CA
   Kruse, M
   Mogensen, O
   Bille, C
   Sorensen, JA
   Lamont, RF
   Wu, C
   Heidemann, L
   Ibsen, M
   Laursen, J
   Ovesen, P
   Rorbye, C
   Tanvig, M
   Joergensen, J
AF Hyldig, N.
   Vinter, C. A.
   Kruse, M.
   Mogensen, O.
   Bille, C.
   Sorensen, J. A.
   Lamont, R. F.
   Wu, C.
   Heidemann, L. N.
   Ibsen, M. H.
   Laursen, J. B.
   Ovesen, P. G.
   Rorbye, C.
   Tanvig, M.
   Joergensen, J. S.
TI Prophylactic incisional negative pressure wound therapy reduces the risk
   of surgical site infection after caesarean section in obese women: a
   pragmatic randomised clinical trial
SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Article
DE Caesarean section; incisional negative pressure wound therapy; obesity;
   surgical site infection
ID CDC DEFINITIONS; MANAGEMENT; EQ-5D-3L
AB Objective To evaluate the reduction of surgical site infections by prophylactic incisional negative pressure wound therapy compared with standard postoperative dressings in obese women giving birth by caesarean section. Design Multicentre randomised controlled trial. Setting Five hospitals in Denmark. Population Obese women (prepregnancy body mass index (BMI) >= 30 kg/m(2)) undergoing elective or emergency caesarean section. Method The participants were randomly assigned to incisional negative pressure wound therapy or a standard dressing after caesarean section and analysed by intention-to-treat. Blinding was not possible due to the nature of the intervention. Main outcome measures The primary outcome was surgical site infection requiring antibiotic treatment within the first 30 days after surgery. Secondary outcomes included wound exudate, dehiscence and health-related quality of life. Results Incisional negative pressure wound therapy was applied to 432 women and 444 women had a standard dressing. Demographics were similar between groups. Surgical site infection occurred in 20 (4.6%) women treated with incisional negative pressure wound therapy and in 41 (9.2%) women treated with a standard dressing (relative risk 0.50, 95% CI 0.30-0.84; number needed to treat 22; P = 0.007). The effect remained statistically significant when adjusted for BMI and other potential risk factors. Incisional negative pressure wound therapy significantly reduced wound exudate whereas no difference was found for dehiscence and quality of life between the two groups. Conclusion Prophylactic use of incisional negative pressure wound therapy reduced the risk of surgical site infection in obese women giving birth by caesarean section.
C1 [Hyldig, N.; Bille, C.; Sorensen, J. A.; Heidemann, L. N.] Univ Southern Denmark, Inst Clin Res, Odense Univ Hosp, Dept Plast Surg, JB Winslowsvej 4,Entrance 20,1st Floor, DK-5000 Odense C, Denmark.
   [Hyldig, N.; Vinter, C. A.; Lamont, R. F.; Wu, C.; Tanvig, M.; Joergensen, J. S.] Univ Southern Denmark, Inst Clin Res, Odense Univ Hosp, Dept Gynaecol & Obstet, Odense, Denmark.
   [Hyldig, N.] Odense Univ Hosp, OPEN Odense Patient Data Explorat Network, Odense, Denmark.
   [Kruse, M.] Univ Southern Denmark, Inst Publ Hlth, Danish Ctr Hlth Econ DaCHE, Odense, Denmark.
   [Mogensen, O.] Karolinska Univ Hosp, Dept Pelv Canc, Stockholm, Sweden.
   [Mogensen, O.] Karolinska Inst, Stockholm, Sweden.
   [Lamont, R. F.] UCL, Northwick Pk Inst Med Res Campus, Div Surg, London, England.
   [Heidemann, L. N.; Tanvig, M.] Lillebaelt Hosp, Dept Gynaecol & Obstet, Kolding, Denmark.
   [Ibsen, M. H.] Hosp Southern Jutland, Dept Gynaecol & Obstet, Esbjerg, Denmark.
   [Laursen, J. B.; Rorbye, C.] Univ Copenhagen, Hvidovre Hosp, Dept Gynaecol & Obstet, Hvidovre, Denmark.
   [Ovesen, P. G.] Aarhus Univ Hosp, Dept Gynaecol & Obstet, Aarhus, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Odense University Hospital; University of Southern Denmark;
   Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet; University of London; University College London; University
   of Copenhagen; Aarhus University
RP Hyldig, N (通讯作者)，Univ Southern Denmark, Inst Clin Res, Odense Univ Hosp, Dept Plast Surg, JB Winslowsvej 4,Entrance 20,1st Floor, DK-5000 Odense C, Denmark.
EM nana.hyldig@rsyd.dk
RI Sørensen, Jens Ahm/D-6279-2014; Mogensen, Ole/Q-1894-2015; Hyldig,
   Nana/AAH-5220-2020
OI Sørensen, Jens Ahm/0000-0003-4903-0094; Vinter, Christina
   Anne/0000-0001-5084-6053; Mogensen, Ole/0000-0001-7655-9909; Hyldig,
   Nana/0000-0001-6758-6294
FU University of Southern Denmark; Odense University Hospital; Region of
   Southern Denmark; Lundbeckfonden; iNPWT device manufacturer Smith
   Nephew; Novo Nordisk Fonden [NNF15OC0014596] Funding Source:
   researchfish; Steno Diabetes Center Aarhus (SDCA) [506] Funding Source:
   researchfish; Steno Diabetes Center Odense (SDCO) [SDCO Research 002]
   Funding Source: researchfish
FX Funding for this peer-reviewed, investigator-initiated clinical trial
   was provided by grants from the University of Southern Denmark, Odense
   University Hospital, the Region of Southern Denmark, Lundbeckfonden, and
   an unrestricted grant from the iNPWT device manufacturer Smith & Nephew
   (devices and operating funding). None of these sources of funds had an
   influence on study design, data collection, data analyses,
   interpretation of results or writing of the report.
CR Allen DB, 1997, ARCH SURG-CHICAGO, V132, P991
   [Anonymous], 2016, Global Guidelines for the Prevention of Surgical Site Infection
   [Anonymous], SURG SIT INF PREV TR
   [Anonymous], DATA RESOURCE PROFIL
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NR 33
TC 74
Z9 87
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1470-0328
EI 1471-0528
J9 BJOG-INT J OBSTET GY
JI BJOG
PD APR
PY 2019
VL 126
IS 5
BP 628
EP 635
DI 10.1111/1471-0528.15413
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA HN7AY
UT WOS:000460341700016
PM 30066454
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Innocenti, M
   Santini, M
   Dreassi, E
   Martin, R
   Melita, D
   Colombini, B
   Innocenti, A
AF Innocenti, Marco
   Santini, Mariella
   Dreassi, Emanuela
   Martin, Robin
   Melita, Dario
   Colombini, Barbara
   Innocenti, Alessandro
TI Effects of Cutaneous Negative Pressure Application on Perforator Artery
   Flow in Healthy Volunteers: A Preliminary Study
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE microsurgery; perforator flap; perforator; microsurgical procedures
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; BLOOD-FLOW; ENDOTHELIAL-CELLS;
   FLAPS
AB Background The creation of skin flaps based on small perforator vessels is an increasingly popular procedure nowadays; the optimization of their blood supply enhances surgical success. This study evaluates the effects on the flowmetries of 7 days' negative pressure application on the skin surface overlying the muscle fascia emergence of periumbilical perforators of the deep inferior epigastric artery (DIEA).
   Methods Ten volunteer participants were enrolled. In each subject, one periumbilical perforator of the DIEA was identified on each side of the abdomen using an eco-color-Doppler. One of them was used as the control group, while the other (the study group) underwent 80mm Hg negative pressure for 7 days. The flowmetries of both perforators were measured before and after the application of negative pressure wound therapy.
   Results After the application of negative pressure, randomly applied on the skin surface over one of the two selected periumbilical perforators, an increase in the flowmetries was observed in both groups of perforators (2.74 cm/s; p <0.0001). The relative flowmetry increase in the control group was 9.55% (2.735 cm/s), while in the study group it was 44.03% (8.748 cm/s).
   Conclusion The application of negative pressure system on the skin surface over the muscle fascia emergence of the selected periumbilical perforators showed an increase in flowmetry. Although this is a preliminary study, this simple and economical procedure before surgery could be usefully employed to increase the rate of success in microsurgical procedures.
C1 [Innocenti, Marco; Melita, Dario; Innocenti, Alessandro] Careggi Univ Hosp, Dept Plast & Reconstruct Microsurg, Viale Giacomo Matteotti 42, I-50132 Florence, Italy.
   [Santini, Mariella] Careggi Univ Hosp, Dept Cardiovasc Diagnost, Florence, Italy.
   [Dreassi, Emanuela] Univ Florence, Dept Stat Informat Applicaz G Parenti DiSIA, Florence, Italy.
   [Martin, Robin] Sci Consulting, Foggathorpe, East Yorkshire, England.
   [Colombini, Barbara] Univ Florence, Sch Human Hlth Sci, Sect Physiol Sci, Dept Expt & Clin Med, Florence, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi;
   University of Florence; Azienda Ospedaliero Universitaria Careggi;
   University of Florence; University of Florence
RP Innocenti, A (通讯作者)，Careggi Univ Hosp, Dept Plast & Reconstruct Microsurg, Viale Giacomo Matteotti 42, I-50132 Florence, Italy.
EM innocentialessandro@alice.it
RI COLOMBINI, Barbara/AAG-3272-2020; innocenti, alessandro/KIC-1725-2024;
   Dreassi, Emanuela/B-5728-2012; Melita, Dario/OFO-1701-2025
OI COLOMBINI, Barbara/0000-0003-1397-9791; innocenti,
   alessandro/0000-0002-6959-4455; Martin, Robin/0000-0002-9314-0437;
   Dreassi, Emanuela/0000-0002-4863-1800; INNOCENTI,
   Marco/0000-0003-3533-1398; Melita, Dario/0000-0003-0560-800X
CR [Anonymous], 1835, LANCET
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NR 24
TC 5
Z9 6
U1 0
U2 1
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD MAR
PY 2019
VL 35
IS 3
BP 189
EP 193
DI 10.1055/s-0038-1668157
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HO1AL
UT WOS:000460637500005
PM 30112753
DA 2026-07-24
ER
PT J
AU Kamus, L
   Rameau, M
   Theoret, C
AF Kamus, Louis
   Rameau, Marie
   Theoret, Christine
TI Feasibility of a disposable canister-free negative-pressure wound
   therapy (NPWT) device for treating open wounds in horses
SO BMC VETERINARY RESEARCH
LA English
DT Article
DE Horse; Wound; Negative pressure wound therapy; Feasibility
ID VACUUM-ASSISTED CLOSURE; DISTAL EXTREMITY; SKIN-GRAFTS; MANAGEMENT; RISK
AB BackgroundWounds are among the most common medical conditions affecting horses and have a major economic impact on the horse industry. Wound healing in horses is distinct to that documented in other species, and often results in delayed healing and extensive scarring, with compromised functional and aesthetic outcomes. To date, there is no conventional method objectively proven to accelerate healing or to successfully prevent complications associated with second intention healing. Several effects of Negative Pressure Wound Therapy (NPWT) may be particularly useful to the management of wounds in horses. However, cumbersome designs of classic NPWT devices render them unsuitable for equine practice. A new lightweight, portable and disposable unit of NPWT (PICO (R)), should facilitate the use of this modality by equine practitioners. The aim of this study was to evaluate the feasibility of using this canister-free system to treat experimental open wounds in horses.ResultsNo difficulties were encountered with the application or maintenance of the PICO (R) system during the ex vivo experiment or during the preliminary in vivo experiment conducted on intact skin. All horses readily tolerated the PICO (R) but difficulties with adhesion and seal prevented the completion of the experimental wound study despite the use of many adjunctive adhesives.ConclusionThe current PICO (R) dressing design is not suitable to be used as a dressing for open wounds in horses though the device is well tolerated by equine patients. A dressing with a wider adhesive edge, a superior adhesive and a more flexible pad would likely be better adapted to enable its future use in equine practice.
C1 [Kamus, Louis; Rameau, Marie; Theoret, Christine] Univ Montreal, Dept Biomed Vet, 3200 Rue Sicotte, St Hyacinthe, PQ J2S 2M2, Canada.
C3 Universite de Montreal
RP Kamus, L (通讯作者)，Univ Montreal, Dept Biomed Vet, 3200 Rue Sicotte, St Hyacinthe, PQ J2S 2M2, Canada.
EM louis.j.kamus@umontreal.ca
RI /C-7320-2015; Kamus, Louis/ABY-4699-2022
OI Kamus, Louis/0000-0002-7192-3377
FU ACVS foundation [2881]
FX This study was partially supported by an unrestricted research grant
   from the ACVS foundation (#2881) and an in-kind donation from Smith &
   Nephew Canada. The funding has no role in the conception or execution of
   the study.
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   [No title captured]
NR 40
TC 10
Z9 11
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1746-6148
J9 BMC VET RES
JI BMC Vet. Res.
PD MAR 6
PY 2019
VL 15
AR 78
DI 10.1186/s12917-019-1829-5
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA HO3AZ
UT WOS:000460791600002
PM 30841889
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hall, C
   Regner, J
   Abernathy, S
   Isbell, C
   Isbell, T
   Kurek, S
   Smith, R
   Frazee, R
AF Hall, Chad
   Regner, Justin
   Abernathy, Stephen
   Isbell, Claire
   Isbell, Travis
   Kurek, Stan
   Smith, Randall
   Frazee, Richard
TI Surgical Site Infection after Primary Closure of High-Risk Surgical
   Wounds in Emergency General Surgery Laparotomy and Closed
   Negative-Pressure Wound Therapy
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article; Proceedings Paper
CT 130th Annual Meeting of the Southern-Surgical-Association
CY DEC, 2018
CL Palm Beach, FL
SP So Surg Assoc
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; MANAGEMENT; METAANALYSIS;
   SYSTEM
AB BACKGROUND: We hypothesized that the universal adoption of closed wounds with negative pressure wound therapy (NPWT) in emergency general surgery patients would result in low superficial surgical infection (SSI) rates.
   STUDY DESIGN: We performed a retrospective observational study using primary wound closure with external NPWT, from May 2017 to May 2018. Patients with active soft tissue infection of the abdominal wall were excluded. Data were analyzed by Fisher's exact tests and Wilcoxon-Mann-Whitney tests, with significance is set at a value of p < 0.05.
   RESULTS: Eighty-five patients (53% female) with a median age of 65 years (range 19 to 98 years) underwent laparotomies. Four patients were excluded for active soft tissue infection. Wounds were classified as dirty (n = 18), contaminated (n = 52), and clean contaminated (n = 11). Median BMI was 27 kg/m(2) (interquartile range [IQR] 23.4 to 33.0 kg/m(2)). Median antibiotic therapy was 4 days (IQR 1 to 7 days). Twenty-six patients had open abdomen management. Patient follow-up was a median of 20 days (range 14 to 120 days). Six patients (7%) developed superficial SSI requiring conversion to open wound management. No patients developed fascial dehiscence. There were no statistically significant associations between SSI and wound class (p = 0.072), antibiotic duration (p = 0.702), open abdomen management, or preoperative risk factors (p < 0.1). Overall morbidity was 38% and mortality was 6%.
   CONCLUSIONS: Primary closure of high risk incisions combined with NPWT is associated with acceptably low SSI rates. Due to the low morbidity and decreased cost associated with this technique, primary closure with NPWT should replace open wound management in the emergency general surgery population. (C) 2018 by the American College of Surgeons. Published by Elsevier Inc. All rights reserved.
C1 [Hall, Chad; Regner, Justin; Abernathy, Stephen; Isbell, Claire; Isbell, Travis; Kurek, Stan; Smith, Randall; Frazee, Richard] Baylor Scott & White Mem Hosp, Dept Trauma & Acute Care Surg, Temple, TX USA.
C3 Baylor Scott & White Health
RP Frazee, R (通讯作者)，2401 S 31st St, Temple, TX 76508 USA.
EM Richard.frazee@bswhealth.org
OI Kurek, Stanley/0000-0001-6608-5404
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   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
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NR 17
TC 28
Z9 39
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD APR
PY 2019
VL 228
IS 4
BP 393
EP 397
DI 10.1016/j.jamcollsurg.2018.12.006
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA HP0LI
UT WOS:000461357100012
PM 30586643
DA 2026-07-24
ER
PT J
AU Egin, S
   Gökcek, B
   Yesiltas, M
   Hot, S
   Karakas, DÖ
AF Egin, Seracettin
   Gokcek, Berk
   Yesiltas, Metin
   Hot, Semih
   Karakas, Dursun Ozgur
TI Improvement of a duodenal leak: Two-way vacuum-assisted closure
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Duodenal leak following omentoplasty; duodenal ulcer perforation;
   vacuum-assisted closure
AB A 55-year-old male patient developed a duodenal re-leak, which caused severe peritonitis, on the second postoperative day after surgery to treat an acutely perforated duodenal ulcer. Relaparotomy was performed 2 days after surgery for the re-leak after omentoplasty. The necrotic omentum was dissociated from the bulbus duodeni. Viable omentum for reinsertion of the omental patch was not found. The turned-outward duodenal mucosa was excised and the duodenal perforation was sutured. Two-way vacuum-assisted closure (VAC) was carried out by taking a liquid culture of the abdomen and washing the abdomen. The two-way VAC exchange procedures were continued every 3 days until the re-leak was terminated. The whole treatment process occurred in the intensive care unit. The duodenal leak was completely stopped by 41 days after surgery. The subcutaneous layer was dissected from the fascial layer of the anterior wall of the abdomen; thus, the abdominal skin was closed without tension and the patient was subsequently discharged. In conclusion, since primary source control is often difficult when treating duodenal leaks, the two-way VAC system is a convenient solution for localizing the source of the peritonitis and removing toxic peritoneal material.
C1 [Egin, Seracettin; Gokcek, Berk; Yesiltas, Metin; Hot, Semih; Karakas, Dursun Ozgur] Hlth Sci Univ, Okmeydani Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
C3 University of Health Sciences Turkey; Istanbul Okmeydani Training &
   Research Hospital
RP Egin, S (通讯作者)，SBU, Okmeydani Egitim & Arastirma Hastanesi, Gen Cerrahi Klin, Istanbul, Turkey.
EM seracettin_egin@hotmail.com
RI Eğin, Seracettin/GQZ-0908-2022; /ADG-3811-2022; Karakas,
   Dursun/C-4089-2015; Yeşiltaş, Metin/R-3639-2018; Gökçek,
   Berk/X-9343-2018
OI Yeşiltaş, Metin/0000-0002-2080-1572; Gökçek, Berk/0000-0001-9989-4152
CR Chalya PL, 2011, WORLD J EMERG SURG, V6, DOI 10.1186/1749-7922-6-31
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
   Egin S, 2018, ULUS TRAVMA ACIL CER, V24, P601, DOI 10.5505/tjtes.2018.23238
   Gupta Sanjay, 2005, BMC Surg, V5, P15
   Kumar K, 2002, Trop Gastroenterol, V23, P190
   Maghsoudi H, 2011, SAUDI J GASTROENTERO, V17, P124, DOI 10.4103/1319-3767.77243
   Sanjanwala S, 2016, International Surgery Journal, P1314, DOI [10.18203/2349-2902.isj20162230, DOI 10.18203/2349-2902.isj20162230, 10.18203/2349-2902.isj20162230, DOI 10.18203/2349-2902.ISJ20162230]
   Sartelli M, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0032-7
NR 8
TC 2
Z9 4
U1 0
U2 3
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD JAN
PY 2019
VL 25
IS 1
BP 89
EP 92
DI 10.5505/tjtes.2018.22934
PG 4
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA HP2DI
UT WOS:000461477900018
PM 30742295
OA Bronze
DA 2026-07-24
ER
PT J
AU Pawar, DRL
   Mitchell, SJ
   Jeyapalina, S
   Hawkes, JE
   Florell, SR
   Bachus, KN
AF Pawar, Divya R. L.
   Mitchell, Saranne J.
   Jeyapalina, Sujee
   Hawkes, Jason E.
   Florell, Scott R.
   Bachus, Kent N.
TI Peri-prosthetic tissue reaction to discontinuation of negative pressure
   wound therapy around porous titanium percutaneous devices
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE negative-pressure wound therapy; percutaneous devices; epithelial
   downgrowth; wound healing; peri-prosthetic tissue
ID VACUUM-ASSISTED CLOSURE; TRANSCUTANEOUS IMPLANTS; MODEL; BONE;
   INFLAMMATION; CONTRACTION; MECHANISMS; BARRIER; REPAIR; PIG
AB Negative pressure wound therapy (NPWT) has been reported to limit epithelial downgrowth, one of the failure mechanisms of percutaneous devices. In a previous study, when NPWT was applied for 4 weeks (NPWT Group) to porous coated titanium percutaneous devices, downgrowth (5 +/- 4%; mean +/- one SD) was significantly reduced compared to untreated controls (Untreated Group) (16 +/- 6%; p0.01). However, it was unclear whether this beneficial effect was sustained when NPWT was discontinued. In order to test this, porous coated titanium percutaneous devices were implanted into 6 hairless guinea pigs. Post-surgery, animals received 4 weeks of NPWT treatment followed by 4 weeks of no treatment (Discontinued Group). At necropsy, the devices and surrounding tissues were harvested and processed. Quantitative downgrowth measurements and qualitative analyses of tissue characteristics were performed, and compared to historical controls (NPWT and Untreated Groups). The Discontinued Group, at 8 weeks, had significantly more downgrowth than the NPWT Group at 4 weeks (23 +/- 3% vs. 5 +/- 4%; p0.01). At 8 weeks, the Discontinued Group qualitatively appeared to exhibit reduced numbers of blood vessels and increased degree of fibrosis compared to the NPWT Group at 4 weeks. This study suggests that NPWT will only be an effective treatment for limiting downgrowth if used continuously. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 564-572, 2019.
C1 [Pawar, Divya R. L.; Jeyapalina, Sujee; Bachus, Kent N.] Univ Utah, George E Wahlen Dept Vet Affairs Med Ctr, Orthopaed Res Labs, Orthopaed Ctr, Salt Lake City, UT 84148 USA.
   [Pawar, Divya R. L.; Mitchell, Saranne J.; Bachus, Kent N.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
   [Jeyapalina, Sujee] Univ Utah, Sch Med, Dept Surg, Salt Lake City, UT 84132 USA.
   [Hawkes, Jason E.; Florell, Scott R.] Univ Utah, Sch Med, Dept Dermatol, Salt Lake City, UT 84132 USA.
C3 Utah System of Higher Education; University of Utah; US Department of
   Veterans Affairs; Utah System of Higher Education; University of Utah;
   Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Bachus, KN (通讯作者)，Univ Utah, George E Wahlen Dept Vet Affairs Med Ctr, Orthopaed Res Labs, Orthopaed Ctr, Salt Lake City, UT 84148 USA.; Bachus, KN (通讯作者)，Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
EM kent.bachus@va.gov
RI ; Bachus, Kent/KYO-7869-2024
OI Mitchell, Saranne J/0000-0002-6473-7648; 
FU US Army Medical Research and Materiel Command [W81XWH-15-C-0058];
   Department of Defense [W81XWH-11-1-0435]; United States Department of
   Veterans Affairs Rehabilitation Research and Development Service
   [I01RX001217, I01RX001246]; Department of Orthopaedics, University of
   Utah School of Medicine
FX Contract grant sponsor: US Army Medical Research and Materiel Command;
   contract grant number: W81XWH-15-C-0058Contract grant sponsor:
   Department of Defense; contract grant number: W81XWH-11-1-0435Contract
   grant sponsor: United States Department of Veterans Affairs
   Rehabilitation Research and Development Service; contract grant numbers:
   I01RX001217; I01RX001246Contract grant sponsor: Department of
   Orthopaedics, University of Utah School of Medicine
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
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NR 36
TC 3
Z9 3
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD APR
PY 2019
VL 107
IS 3
BP 564
EP 572
DI 10.1002/jbm.b.34148
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA HP4YX
UT WOS:000461683400010
PM 29732684
OA Bronze
DA 2026-07-24
ER
PT J
AU Keeney, JA
   Cook, JL
   Clawson, SW
   Aggarwal, A
   Stannard, JP
AF Keeney, James A.
   Cook, James L.
   Clawson, Stacee W.
   Aggarwal, Ajay
   Stannard, James P.
TI Incisional Negative Pressure Wound Therapy Devices Improve Short-Term
   Wound Complications, but Not Long-Term Infection Rate Following Hip and
   Knee Arthroplasty
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE incisional negative pressure wound therapy; wound healing; wound
   complications; total knee arthroplasty; total hip arthroplasty
ID DRESSINGS; SURGERY
AB Background: The potential value of incisional negative pressure wound therapy (iNPWT) on lower extremity total joint arthroplasty (TJA) wound healing has been supported in a few retrospective studies. We performed this prospective, randomized, controlled trial to assess the impact of iNPWT on wound appearance, early complications, and late infection rates following hip and knee TJA compared with a standard surgical dressing.
   Methods: Three-hundred ninety-eight patients undergoing primary or revision lower extremity TJA were randomized into iNPWT or conventional wound dressing groups. Wound healing and early complication rates were assessed at 7, 14, and 35 days after the index surgery. Late infection rates were determined at a mean 2-year follow-up.
   Results: Patients treated with an iNPWT device were more likely to report wound drainage at day 7 (P =.01), but less drainage longer than 14 days (P =.04). Wound drainage was significantly higher for total hip arthroplasty patients at day 7 (P =.04), but differences were not sustained through the other time intervals. Total knee arthroplasty patients with a body mass index > 35 kg/m(2) treated with an iNPWT device experienced fewer complications (1.3% vs 21.6%, P <.01) and fewer dressing-related concerns (1.3% vs 10.8%, P =.02) compared with a conventional dressing. No significant difference in late superficial or deep infection rates was identified between iNPWT and conventional dressing groups (4.0% vs 3.4%, P =.8).
   Conclusion: Our study findings support improved soft tissue healing response with the use of iNPWT devices. While postoperative wound drainage may limit their value following total hip arthroplasty, incisional NPWT devices may have a targeted benefit for elective total knee arthroplasty patients with a body mass index > 35 kg/m(2). Specific study in this higher-risk patient group may be helpful to define the value of iNPWT. (c) 2018 Elsevier Inc. All rights reserved.
C1 [Keeney, James A.; Cook, James L.; Clawson, Stacee W.; Aggarwal, Ajay; Stannard, James P.] Univ Missouri, Dept Orthopaed Surg, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia
RP Keeney, JA (通讯作者)，Univ Missouri, Dept Orthopaed Surg, Grad Med Educ, Adult Hip & Knee Reconstruct Serv, 1100 Virginia Ave, Columbia, MO 65201 USA.
OI Cook, James/0000-0002-0862-995X; Stannard, James P/0000-0001-8467-6494
FU Smith & Nephew Orthopaedics
FX The authors would like to thank Vicki Jones and Kevin Matz for their
   contributions to data collection and analysis. Our institution received
   research funding from Smith & Nephew Orthopaedics that was related to
   this study.
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NR 15
TC 42
Z9 44
U1 0
U2 4
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD APR
PY 2019
VL 34
IS 4
BP 723
EP 728
DI 10.1016/j.arth.2018.12.008
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HP4YZ
UT WOS:000461683700020
PM 30612833
DA 2026-07-24
ER
PT J
AU Nuutila, K
   Yang, L
   Broomhead, M
   Proppe, K
   Eriksson, E
AF Nuutila, Kristo
   Yang, Lu
   Broomhead, Michael
   Proppe, Karl
   Eriksson, Elof
TI Novel negative pressure wound therapy device without foam or gauze is
   effective at-50 mmHg
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; GRANULATION-TISSUE;
   BACTERIAL LOAD; INSTILLATION; JELONET; BURNS
AB Negative pressure wound therapy (NPWT) promotes healing in acute or chronic wounds. Conventional NPWT devices consist of a filler (such as foam or gauze) that covers the wound and of a permeable membrane and tubing that connects the space under the membrane to a suction pump. The permeable membrane increases airflow and thus increases the required pump capacity that can cause patient discomfort or even ischemia in wounds with compromised vascularity. In addition, foam or gauze may fragment and become colonized with bacteria over time. To mitigate these, negative aspects, we have developed a new impermeable single layer component membrane dressing to deliver NPWT that does not need a foam or gauze to function. Therefore, the purpose of this study was to introduce this novel NPWT system (platform wound device, PWD) and evaluate its usability and effectiveness in the treatment of porcine full-thickness burns. A total of 48 burn wounds were created across four Yorkshire pigs on the dorsum. Wounds were created on day 0 and continuous NPWT with -50 mmHg and - 80 mmHg was initiated immediately. Subsequently, the burns were debrided on day 3 and animals were euthanized on day 7. The efficacy of the PWD on wound healing and reduction of bacterial burden was measured and compared to wounds that did not receive NPWT. The results showed that PWD promoted wound healing by outperforming the wounds that did not receive NPWT and that PWD was efficient at reducing bacteria from the burn eschar and from the wound bed. In conclusion, this study demonstrated that PWD promoted wound healing with a negative pressure as low as -50 mmHg, which likely benefits healing and avoids potential safety issues.
C1 [Nuutila, Kristo; Yang, Lu; Broomhead, Michael; Proppe, Karl; Eriksson, Elof] Appl Tissue Technol LLC, Hingham, MA 02043 USA.
RP Nuutila, K; Eriksson, E (通讯作者)，Appl Tissue Technol LLC, Hingham, MA 02043 USA.
EM kristo.nuutila@gmail.com; elof@comcast.net
FU USAMRAA [W81XWH-14-C-0015]
FX The views, opinions and/or findings contained in this report are those
   of the author(s) and should not be construed as an official Department
   of the Army position, policy or decision unless so designated by other
   documentation. This material is based upon work supported by the USAMRAA
   under Contract No W81XWH-14-C-0015.
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NR 39
TC 19
Z9 23
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2019
VL 27
IS 2
BP 162
EP 169
DI 10.1111/wrr.3
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA HP5ND
UT WOS:000461722900003
PM 30378215
DA 2026-07-24
ER
PT J
AU Cozza, V
   Pascale, MM
   Pepe, G
   Panzera, R
   Magalini, S
   Gui, D
AF Cozza, Valerio
   Pascale, Marco M.
   Pepe, Gilda
   Panzera, Rocco
   Magalini, Sabina
   Gui, Daniele
TI Empirical measurement of pressure in negative pressure wound therapy for
   infected wounds: How long can it really stay under pressure?
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID SURGICAL SITE INFECTION
AB Surgical site infections represent one of the most common surgical complications. Negative pressure wound therapy is considered an effective wound management system, based on the principle that a negative pressure inside the wound can suction fluids and approximate wound edges. With the negative pressure wound therapy systems commercially available it is assumed that the pressure inside the wound is stable at the set values. We conducted a prospective experimental study to investigate this. The negative pressure level achieved inside the dressing was investigated at a standard distance from the pad of suction and at specific times in patients with surgical site infections. Pressure measurements were performed in 28 dressings in 14 patients admitted to the Emergency Surgery Department between April 2016 and June 2017. In general, the machine was set at a pressure of -100 mmHg. Negative pressure was measured with a portable pressure reader in the dressing sponge at a distance of 0, 1.5, and 3 cm from the suction pad at the time of dressing change at 24 and 48 hours. The data suggest that there is a significant decrease in negative pressure at both 1.5 and 3 cm from the suction pad at 48 hours from the dressing change (p = 0.0001 and p < 0.0001, respectively). This preliminary study shows with statistical significance that the pressure inside the sponge of a negative pressure wound therapy system decreases after 48 hours, confirming that the pressure inside the system is not the same as the pressure reported by the machine and, instead of being stable, changes overtime.
C1 [Cozza, Valerio; Pascale, Marco M.; Pepe, Gilda; Panzera, Rocco; Magalini, Sabina; Gui, Daniele] Univ Cattolica Sacro Cuore, Fdn Policlin A Gemelli, Emergency Surg Dept, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Cozza, V (通讯作者)，Univ Cattolica Sacro Cuore, Ist Clin Chirurg 9B, Largo Francesco Vito 1, I-00168 Rome, Italy.
EM valerio.cozza@gmail.com
RI Pascale, Marco Maria/AAK-5807-2020
OI Pascale, Marco Maria/0000-0003-1355-0207; Panzera, Rocco
   Maria/0000-0001-7015-2964
CR [Anonymous], 2013, MPL115A1
   Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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   Chadi SA, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0817-8
   Delgado A, 2016, SAGE OPEN MED, V4, DOI 10.1177/2050312115624988
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Kobayashi M, 2008, WORLD J SURG, V32, P1142, DOI 10.1007/s00268-008-9536-6
   Konishi T, 2006, ANN SURG, V244, P758, DOI 10.1097/01.sla.0000219017.78611.49
   Magill SS, 2014, NEW ENGL J MED, V370, P1198, DOI 10.1056/NEJMoa1306801
   McNulty A, 2010, WOUNDS, V22, P114
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Yamamoto T, 2015, BMC SURG, V15, DOI 10.1186/s12893-015-0115-0
NR 12
TC 2
Z9 3
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2019
VL 27
IS 2
BP 190
EP 195
DI 10.1111/wrr.12693
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA HP5ND
UT WOS:000461722900006
PM 30548524
DA 2026-07-24
ER
PT J
AU Ruggieri, VG
   Olivier, ME
   Aludaat, C
   Rosato, S
   Marticho, P
   Saade, YA
   Lefebvre, A
   Poncet, A
   Rubin, S
   Biancari, F
AF Ruggieri, Vito Giovanni
   Olivier, Maud-Emmanuelle
   Aludaat, Chadi
   Rosato, Stefano
   Marticho, Paul
   Saade, Yves Assad
   Lefebvre, Annick
   Poncet, Anne
   Rubin, Sylvain
   Biancari, Fausto
TI Negative Pressure versus Conventional Sternal Wound Dressing in Coronary
   Surgery Using Bilateral Internal Mammary Artery Grafts
SO HEART SURGERY FORUM
LA English
DT Article
ID THORACIC ARTERY; THERAPY; LAPAROTOMY; TRIAL
AB Background: Sternal wound infection (SWI) is a major complication occurring often after coronary artery bypass grafting (CABG) using bilateral internal mammary artery (BIMA) grafts. The aim of this study is to assess whether such a risk may be reduced by using incision negative pressure wound therapy (INPWT).
   Methods: Data on patients undergoing isolated CABG using BIMA grafts at the Reims University Hospital, France, from 2013 to 2016 without or with INPWT was prospectively collected.
   Results: INPWT was used in 161 patients and conventional sterile wound dressing was used in 266 patients. Propensity score matching resulted in 128 pairs with similar characteristics. SWIs were similarly distributed between the conventional sterile wound dressing (10.9%) and the INPWT cohorts (10.2%) (P = 1.00). Patients treated with INPWT had a lower rate of deep SWI/mediastinitis than patients who had conventional sterile dressing (5.5% versus 10.2%, P = .210), but the difference did not reach statistical significance. Tests for interaction confirmed these findings in different patient subgroups.
   Conclusion: The routine use of INPWT may not significantly reduce the risk of SWI in patients undergoing BIMA grafting. In view of previous reports showing a benefit with the use of this method, a large randomized study is justified to assess the efficacy of INPWT in patients undergoing cardiac surgery.
C1 [Ruggieri, Vito Giovanni; Olivier, Maud-Emmanuelle; Aludaat, Chadi; Marticho, Paul; Saade, Yves Assad; Rubin, Sylvain] Robert Debre Univ Hosp, Div Cardiovasc & Thorac Surg, Reims, France.
   [Poncet, Anne] Robert Debre Univ Hosp, Unite Anesthesie Reanimat Cardiothorac, Reims, France.
   [Ruggieri, Vito Giovanni; Rubin, Sylvain] URCA, Reims, France.
   [Rosato, Stefano] Ist Super Sanita, Ctr Global Hlth, Rome, Italy.
   [Lefebvre, Annick] CHU Reims, Hop Maison Blanche, Equipe Operat Hyg, Reims, France.
   [Biancari, Fausto] Univ Turku, Turku Univ Hosp, Heart Ctr, Turku, Finland.
   [Biancari, Fausto] Univ Turku, Dept Surg, Turku, Finland.
   [Biancari, Fausto] Univ Oulu, Dept Surg, Oulu, Finland.
C3 Universite de Reims Champagne-Ardenne; CHU de Reims; Universite de Reims
   Champagne-Ardenne; CHU de Reims; Universite de Reims Champagne-Ardenne;
   Istituto Superiore di Sanita (ISS); Universite de Reims
   Champagne-Ardenne; CHU de Reims; University of Turku; University of
   Turku; University of Oulu
RP Ruggieri, VG (通讯作者)，Robert Debre Univ Hosp, Div Cardiovasc & Thorac Surg, Reims, France.
EM vgruggieri@chu-reims.fr
RI ; Rosato, Stefano/LIC-2981-2024; Biancari, Fausto/A-1039-2008
OI aludaat, chadi/0000-0002-9825-3852; Ruggieri, Vito
   Giovanni/0000-0002-2723-8700; Rosato, Stefano/0000-0002-6690-5537;
   Biancari, Fausto/0000-0001-5028-8186
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   Deo SV, 2015, INT J SURG, V16, P163, DOI 10.1016/j.ijsu.2015.01.008
   Grauhan O, 2014, INT WOUND J, V11, P6, DOI 10.1111/iwj.12294
   Li PY, 2017, SCAND J SURG, V106, P189, DOI 10.1177/1457496916668681
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NR 13
TC 17
Z9 19
U1 0
U2 2
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PY 2019
VL 22
IS 2
BP E92
EP E96
DI 10.1532/hsf.2269
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA HP6XW
UT WOS:000461831600005
PM 31013216
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Paula, FM
   Pinheiro, EA
   de Oliveira, VM
   Ferreira, CM
   Monreal, MTFD
   Rolan, MD
   de Matos, VTG
AF Paula, Fabiana Martins
   Pinheiro, Edivania Anacleto
   de Oliveira, Vanessa Marcon
   Ferreira, Cristiane Munaretto
   Ferreira Duenhas Monreal, Maria Tereza
   Rolan, Marisa Dias
   Gubert de Matos, Vanessa Terezinha
TI A case report of successful treatment of necrotizing fasciitis using
   negative pressure wound therapy
SO MEDICINE
LA English
DT Article
DE injuries and lesions; injury closure techniques; necrotizing fasciitis;
   treatment of wounds with negative pressure; wounds healing
ID VACUUM-ASSISTED CLOSURE
AB Rationale: Necrotizing fasciitis is a destructive tissue infection with rapid progression and high mortality. Thus, it is necessary that high-performance dressings be introduced as possibilities of treatment.
   Patient concerns: Female patient, 44 years of age, admitted to hospital unit complaining of lesion in the gluteal region and drainage of purulent secretion in large quantity followed by necrosis.
   Diagnoses: The diagnosis of necrotizing fasciitis was carried out with the computerized tomography examination result and its association with the patient's clinical condition.
   Interventions: Initially, successive debridements were carried out in lower limbs as well as primary dressing with enzymatic debriding action until indication of negative pressure wound therapy, for the period of 2 weeks in the right lower limb and for 5 weeks in the left lower limb, with changes every 72h. Dressing with saline gauze was used at the end of this therapy until hospital discharge.
   Outcomes: After the use of negative pressure wound therapy, we observed the presence of granulation tissue, superficialization and reduction of lesion extension. The patient presented good tolerance and absence of complications.
   Lessons: Negative pressure wound therapy constituted a good option for the treatment of necrotizing fasciitis, despite the scarcity of protocols published on the subject.
C1 [Paula, Fabiana Martins; Pinheiro, Edivania Anacleto; Gubert de Matos, Vanessa Terezinha] Univ Fed Mato Grosso do Sul, Residencia Multiprofiss Cuidados Continuados Inte, Campo Grande, MS, Brazil.
   [Pinheiro, Edivania Anacleto] Univ Fed Mato Grosso do Sul, Hosp Sao Juliao, Campo Grande, MS, Brazil.
   [de Oliveira, Vanessa Marcon; Ferreira, Cristiane Munaretto; Ferreira Duenhas Monreal, Maria Tereza; Gubert de Matos, Vanessa Terezinha] Univ Fed Mato Grosso do Sul, Fac Ciencias Farmaceut Alimetos & Nutr, Campo Grande, MS, Brazil.
   [Rolan, Marisa Dias] Univ Fed Mato Grosso do Sul, Inst Integrado Saude, Campo Grande, MS, Brazil.
C3 Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato
   Grosso do Sul; Universidade Federal de Mato Grosso do Sul; Universidade
   Federal de Mato Grosso do Sul
RP de Matos, VTG (通讯作者)，Univ Fed Mato Grosso do Sul, Campo Grande, MS, Brazil.
EM vanessa.matos@ufms.br
RI Gubert, Vanessa Terezinha/A-9484-2013; Ferreira Duenhas Monreal, Maria
   Tereza/D-4987-2019; DE PAULA, FABIANA/KIE-5346-2024; Marcon de Oliveira,
   Vanessa/AAD-4470-2019
OI Gubert, Vanessa Terezinha/0000-0002-9361-2780; Ferreira Duenhas Monreal,
   Maria Tereza/0000-0002-7472-6504; DE PAULA, FABIANA/0000-0003-3343-0149;
   Marcon de Oliveira, Vanessa/0000-0002-9123-9206
CR Anaya DA, 2015, ARCH SURG-CHICAGO, V140, P151
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   Beldon P., 2010, Surgery, V28, P409, DOI [10.1016/j.mpsur.2010.05.007, DOI 10.1016/J.MPSUR.2010.05.007]
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   Horta R, 2016, WOUNDS, V28, P200
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Jabbour G, 2016, WORLD J EMERG SURG, V11, DOI 10.1186/s13017-016-0097-y
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NR 19
TC 15
Z9 17
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2019
VL 98
IS 2
AR e13283
DI 10.1097/MD.0000000000013283
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HQ3CX
UT WOS:000462286300002
PM 30633151
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, J
   Shi, JB
   Hong, P
   Wang, YS
   Ze, HR
   Lee, RJ
   Tang, X
AF Li, Jin
   Shi, Jie Bao
   Hong, Pan
   Wang, Yu Shang
   Ze, Hao Ren
   Lee, Rushyuan Jay
   Tang, Xin
TI Combined treatment with vacuum sealing drainage, TopClosure device, and
   Ilizarov technique for traumatic hemipelvectomy A rare case report of
   successful repairing of large-size soft tissue defects
SO MEDICINE
LA English
DT Article
DE Ilizarov technique; large-size soft tissue defects; RNPT; TopClosure
   device; traumatic hemipelvectomy
ID ASSISTED CLOSURE VAC(TM); INJURIES
AB Rationale: Traumatic hemipelvectomy is a rare but lethal catastrophic injury.
   Patient concerns: A case of a very young child with open fracture of left sacroiliac joint dislocation and pubic symphysis diastasis, suffered from a severe large-size soft tissue defects.
   Diagnosis: Traumatic hemipelvectomy.
   Interventions: Complete amputation was performed and three kinds of surgical techniques including regulated negative pressure-assisted wound therapy (RNPT), TopClosure device, and Ilizarov technique were jointly utilized to secure closure in the further revisions of the soft tissue injury and reconstruct reconstructive surgery.
   Outcomes: Six months after hospital discharge, the patient was able to ambulate with a single limb and a prosthesis and she is independent in many activities of daily living currently.
   Lessons: We report this case to share experience with other clinicians in the management of this deadly extensive defects after traumatic hemipelvectomy in patients.
C1 [Li, Jin; Shi, Jie Bao; Hong, Pan; Wang, Yu Shang; Ze, Hao Ren; Tang, Xin] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Orthopaed Surg, Wuhan 430022, Hubei, Peoples R China.
   [Lee, Rushyuan Jay] Johns Hopkins Univ Hosp, Bloomberg Childrens Hosp, Dept Orthopaed Surg, Baltimore, MD 21287 USA.
C3 Huazhong University of Science & Technology; Johns Hopkins University;
   Johns Hopkins Medicine
RP Tang, X (通讯作者)，Wuhan Union Hosp, Wuhan 430022, Hubei, Peoples R China.
EM dr_xintang@hust.edu.cn
OI Tang, Xin/0000-0002-6860-6530
FU National Natural Science Foundation of China [81470100]
FX National Natural Science Foundation of China (81470100).
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NR 19
TC 6
Z9 8
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2019
VL 98
IS 4
AR e14205
DI 10.1097/MD.0000000000014205
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HQ3FY
UT WOS:000462296900045
PM 30681595
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fan, L
   Luo, H
   Liu, B
   Fa, XN
   Liu, T
   Ma, C
AF Fan, Lei
   Luo, Huan
   Liu, Bing
   Fa, Xianen
   Liu, Tao
   Ma, Chao
TI Clinical treatment of diabetic foot ulcer combined with Budd-Chiari
   syndrome A case report
SO MEDICINE
LA English
DT Article
DE Budd-Chiari syndrome; clinical practice; debridement; diabetic foot
   ulcer; foam dressing; moist healing; vacuum sealing drainage
ID MOIST
AB Rationale: Diabetic foot ulcer is a severe complication of diabetes, and most patients with diabetic foot ulcer require amputation. The incidence of Budd-Chiari syndrome is low; it is relatively rare. Diabetic foot ulcer combined with Budd-Chiari syndrome has not been reported so far.
   Patient concerns: A 52-year-old man presented with uncontrolled high body temperature, continued expansion of the lower leg and foot ulcer with increasing malodor.
   Diagnosis: The patient was diagnosed with Wagner grade 4 diabetic foot ulcer combined with Budd-Chiari syndrome.
   Interventions: Critical treatment was performed immediately after his admission to the hospital. After the patient's condition was stable, we performed an interventional procedure to relieve the inferior vena cava obstruction. Debridement was then performed on the diabetic foot ulcer. Finally, skin grafting was performed due to condition of the wound. We completed moist healing and vacuum sealing drainage throughout the treatment process.
   Outcomes: The patient was hospitalized for 56 days, and all his right lower extremity ulcers eventually healed.
   Lessons: In the treatment of diabetic foot ulcer combined with Budd-Chiari syndrome, it is necessary to develop a unified treatment plan that includes the timely treatment of Budd-Chiari syndrome upon admission, the strategic use of debridement, and the application of moist healing and vacuum sealing drainage.
C1 [Fan, Lei; Liu, Tao; Ma, Chao] Zhengzhou Univ, Peoples Hosp, Henan Prov Peoples Hosp, Dept Orthoped Surg, Zhengzhou, Henan, Peoples R China.
   [Luo, Huan] Charite Univ Med Berlin, Dept Ophthalmol, Campus Virchow, Berlin, Germany.
   [Luo, Huan] Zhengzhou Univ, Peoples Hosp, Henan Prov Peoples Hosp, Dept Ophthalmol, Zhengzhou, Henan, Peoples R China.
   [Liu, Bing; Fa, Xianen; Ma, Chao] Zhengzhou Univ, Affiliated Hosp 2, Dept Cardiovasc Surg, Zhengzhou, Henan, Peoples R China.
   [Ma, Chao] Charite Univ Med Berlin, Dept Cardiol, Campus Virchow, Berlin, Germany.
   [Ma, Chao] German Ctr Cardiovasc Res DZHK, Partner Site Berlin, Berlin, Germany.
C3 Zhengzhou University; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Zhengzhou University;
   Zhengzhou University; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; German Centre for
   Cardiovascular Research
RP Ma, C (通讯作者)，Charite Univ Med Berlin, Berlin, Germany.
EM chao.ma@charite.de
RI Ma, Chao/HLQ-3961-2023
OI Ma, Chao/0000-0003-1444-4668
FU Zhengzhou University Overseas Virtual Research Institute Special Fund,
   Zhengzhou University
FX This study was funded by Zhengzhou University Overseas Virtual Research
   Institute Special Fund, Zhengzhou University.
CR Amer Diabet Assoc, 2018, DIABETES CARE, V41, pS55, DOI 10.2337/dc18-S006
   Anghel EL, 2016, PLAST RECONSTR SURG, V138, p82S, DOI 10.1097/PRS.0000000000002651
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NR 11
TC 4
Z9 4
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2019
VL 98
IS 4
AR e14224
DI 10.1097/MD.0000000000014224
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HQ3FY
UT WOS:000462296900050
PM 30681600
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rosenbaum, AJ
   Banerjee, S
   Rezak, KM
   Uhl, RL
AF Rosenbaum, Andrew J.
   Banerjee, Samik
   Rezak, Kristen M.
   Uhl, Richard L.
TI Advances in Wound Management
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; CALCIUM ALGINATE;
   THERAPY; MATRIX; REGENERATION; EXPRESSION; INJURY; SKIN
AB Wound management is a notable healthcare and financial burden, accounting for >$10 billion in annual healthcare spending in the United States. A multidisciplinary approach involving orthopaedic and plastic surgeons, wound care nursing, and medical and support staff is often necessary to improve outcomes. Orthopaedic surgeons must be familiar with the fundamental principles and evidenced-based concepts for the management of acute and chronic wounds. Knowledge of surgical dressings, negative pressure wound therapy, tissue expanders, dermal apposition, biologics, and extracellular matrices can aide practitioners in optimizing wound care.
C1 [Rosenbaum, Andrew J.; Banerjee, Samik; Rezak, Kristen M.; Uhl, Richard L.] Albany Med Ctr, Dept Surg, Albany, NY 12208 USA.
C3 Albany Medical College
RP Rosenbaum, AJ (通讯作者)，Albany Med Ctr, Dept Surg, Albany, NY 12208 USA.
RI /U-6751-2019
OI Rezak, Kristen/0000-0001-7626-5732
CR Alvarez OM, 2017, WOUNDS, V29, P140
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NR 41
TC 56
Z9 66
U1 0
U2 40
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD DEC 1
PY 2018
VL 26
IS 23
BP 833
EP 843
DI 10.5435/JAAOS-D-17-00024
PG 11
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA HQ4VX
UT WOS:000462410500005
PM 30180089
DA 2026-07-24
ER
PT J
AU Borys, S
   Hohendorff, J
   Frankfurter, C
   Kiec-Wilk, B
   Malecki, MT
AF Borys, Sebastian
   Hohendorff, Jerzy
   Frankfurter, Claudia
   Kiec-Wilk, Beata
   Malecki, Maciej T.
TI Negative pressure wound therapy use in diabetic foot syndrome-from
   mechanisms of action to clinical practice
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE amputation; diabetic foot syndrome; foot ulcer; healing; NPWT
ID VACUUM-ASSISTED CLOSURE; MATRIX METALLOPROTEINASES; SUBATMOSPHERIC
   PRESSURE; IWGDF GUIDANCE; BACTERIAL LOAD; BLOOD-FLOW; ULCERS;
   CONTRACTION; GAUZE; FOAM
AB Background Diabetes and its complications constitute a rising medical challenge. Special attention should be given to diabetic foot syndrome (DFS) due to its high rate of associated amputation and mortality. Negative pressure wound therapy (NPWT) is a frequently used supportive modality in a diabetic foot with ulcerations (DFUs).
   Design Here, we reviewed the current knowledge concerning the tissue and molecular mechanisms of NPWT action with an emphasis on diabetes research followed by a summary of clinical DFU studies and practice guidelines.
   Results Negative pressure wound therapy action results in two types of tissue deformations-macrodeformation, such as wound contraction, and microdeformation occurring at microscopic level. Both of them stimulate a wound healing cascade including tissue granulation promotion, vessel proliferation, neoangiogenesis, epithelialization and excess extracellular fluid removal. On the molecular level, NPWT results in an alteration towards more pro-angiogenic and anti-inflammatory conditions. It increases expression of several key growth factors, including vascular endothelial growth factor and fibroblast growth factor 2, while expression of inflammatory cytokinesis reduced. The NPWT application also alters the presence and function of matrix metalloproteinases. Clinical studies in DFU patients showed a superiority of NPWT over standard therapy in terms of efficacy outcomes, primarily wound healing and amputation rate, without a rise in adverse events. International guidelines point to NPWT as an important adjuvant therapy in DFU whose use is expected to increase.
   Conclusions This current knowledge improves our understanding of NPWT action and its tailoring for application in diabetic patients. It may inform the development of new treatments for DFU.
C1 [Borys, Sebastian; Hohendorff, Jerzy; Kiec-Wilk, Beata; Malecki, Maciej T.] Jagiellonian Univ, Med Coll, Dept Metab Dis, Krakow, Poland.
   [Borys, Sebastian; Hohendorff, Jerzy; Kiec-Wilk, Beata; Malecki, Maciej T.] Univ Hosp, Dept Metab Dis, Krakow, Poland.
   [Frankfurter, Claudia] Univ Toronto, Fac Med, Toronto, ON, Canada.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   University of Toronto
RP Malecki, MT (通讯作者)，Jagiellonian Univ, Med Coll, Dept Metab Dis, Krakow, Poland.
EM maciej.malecki@uj.edu.pl
RI Hohendorff, Jerzy/U-1857-2018
OI Hohendorff, Jerzy/0000-0003-1153-8669
FU National Science Centre in Poland [2013/11/B/NZ5/03298]
FX MTM was awarded a grant funded by the National Science Centre in Poland
   "Assessment of molecular mechanisms of negative pressure wound therapy
   in the treatment of neuropathic ulceration in diabetic foot syndrome"
   (Nr 2013/11/B/NZ5/03298).
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NR 64
TC 62
Z9 75
U1 1
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD APR
PY 2019
VL 49
IS 4
AR e13067
DI 10.1111/eci.13067
PG 8
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA HQ6ZP
UT WOS:000462569100005
PM 30600541
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Zayan, NE
   West, JM
   Schulz, SA
   Jordan, SW
   Valerio, IL
AF Zayan, Nichole E.
   West, Julie M.
   Schulz, Steven A.
   Jordan, Sumanas W.
   Valerio, Ian L.
TI Incisional Negative Pressure Wound Therapy: An Effective Tool for Major
   Limb Amputation and Amputation Revision Site Closure
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure; iNPWT; amputation; surgical site infection
ID SURGICAL INCISIONS; MANAGEMENT; FRACTURES; MORTALITY
AB Objective: To evaluate our institutional experience of incisional negative pressure wound therapy (iNPWT) applied immediately after major limb amputation closure or amputation revision closure. Approach: A retrospective review was performed on 25 patients who underwent major limb amputation or amputation revision and had iNPWT placed intraoperatively upon incision closure. Results: Twenty-one patients underwent lower extremity amputation and four underwent upper extremity amputation. Seventeen were primary amputations and eight were amputation revisions. No patients developed dehiscence, seroma, or hematoma. One patient developed a surgical site infection (4%) that was treated with oral antibiotics. The average time to eligibility for prosthetic fitting for lower extremity amputations was 6.3 weeks. Innovation: Amputee patients have increased wound healing demands that can impact prosthetic wear and ambulation status. Stump incisions are located at the distal end of their extremities and often are in areas that have had prior surgical procedures performed. Thus, blood supply to the incision site may not be optimal. iNPWT is an effective incision management technique to promote healing and decrease postoperative complications in this patient population, which can lead to increased mortality. Conclusion: iNPWT is an effective technique of minimizing wound complications in the amputee and should be considered in this high-risk patient population.
C1 [Zayan, Nichole E.; West, Julie M.; Schulz, Steven A.; Jordan, Sumanas W.; Valerio, Ian L.] Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd,Ste 2100, Columbus, OH 43212 USA.
   [Jordan, Sumanas W.] Northwestern Univ, Div Plast Surg, Chicago, IL 60611 USA.
C3 University System of Ohio; Ohio State University; Northwestern
   University
RP Valerio, IL (通讯作者)，Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd,Ste 2100, Columbus, OH 43212 USA.
EM ian.valerio@osumc.edu
RI Valerio, Ian/F-9161-2017
CR Advanced Amputee Solutions, 2012, AMP STAT
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NR 28
TC 18
Z9 19
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD AUG 1
PY 2019
VL 8
IS 8
BP 368
EP 373
DI 10.1089/wound.2018.0935
EA MAR 2019
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IM5UY
UT WOS:000462593600001
PM 31346491
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Papp, AA
AF Papp, Anthony A.
TI Incisional negative pressure therapy reduces complications and costs in
   pressure ulcer reconstruction
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE cost; flap; negative pressure; pressure ulcer; reconstruction
ID SPINAL-CORD-INJURY; WOUND THERAPY; OBESE-PATIENTS; OUTCOMES; SURGERY;
   RISK; INFECTIONS; MANAGEMENT; SORES; FLAP
AB Complications after pressure ulcer reconstruction are common. A complication rate of 21% to 58% and a 27% wound recurrence has been reported. The aim of this study was to decrease postoperative wound-healing complications with incisional negative pressure wound therapy (iNPWT) postoperatively. This was a prospective non-randomised trial with a historic control. Surgically treated pressure ulcer patients receiving iNPWT were included in the prospective part of the study (Treatment group) and compared with the historic patient cohort of all consecutive surgically treated pressure ulcer patients during a 2-year period preceding the initiation of iNPWT (Control). There were 24 patients in the Control and 37 in the Treatment groups. The demographics between groups were similar. There was a 74% reduction in in-hospital complications in the Treatment group (10.8% vs 41.7%, P = 0.0051), 27% reduction in the length of stay (24.8 vs 33.8 days, P = 0.0103), and a 78% reduction in the number of open wounds at 3 months (5.4 vs 25%, P = -0.0481). Recurrent wounds and history of previous surgery were risk factors for complications. Incisional negative pressure wound therapy shortens hospital stay, number of postoperative complications, and the number of recurrent open wounds at 3 months after reconstructive pressure ulcer surgery, resulting in significant cost savings.
C1 [Papp, Anthony A.] Vancouver Gen Hosp, 899 W 12th Ave, Vancouver, BC V5Z 1M9, Canada.
   [Papp, Anthony A.] Univ British Columbia, Div Plast Surg, Vancouver, BC, Canada.
C3 University of British Columbia; University of British Columbia
RP Papp, AA (通讯作者)，Vancouver Gen Hosp, 899 W 12th Ave, Vancouver, BC V5Z 1M9, Canada.
EM anthony.papp@gmail.com
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NR 31
TC 21
Z9 24
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2019
VL 16
IS 2
BP 394
EP 400
DI 10.1111/iwj.13045
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA HQ7VT
UT WOS:000462632200011
PM 30548531
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Polykandriotis, E
   Horch, RE
   Jost, M
   Arkudas, A
   Kees, F
   Schmitz, M
AF Polykandriotis, Elias
   Horch, Raymund E.
   Jost, Matthias
   Arkudas, Andreas
   Kees, Frieder
   Schmitz, Marweh
TI Can systemically administered antibiotics be detected in wound tissues
   and surfaces under negative pressure wound therapy?
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE interstitial fluid; moxifloxacin; negative pressure wound therapy
   (NPWT); pharmacokinetics; wound infection
ID OBESE WOMEN; 400 MG; MOXIFLOXACIN; FLUID; PENETRATION; PHARMACOKINETICS;
   PROPHYLAXIS; MANAGEMENT; VANCOMYCIN; HEALTHY
AB In this study, we evaluated a new aspect of negative pressure wound therapy (NPWT) as an analytical tool for pharmacokinetic studies. Twenty-one patients with soft tissue defects scheduled to receive NPWT were included in this study. Concomitant to NPWT, all patients received intravenous moxifloxacin (MX). At different time intervals, blood plasma levels of MX were sampled and compared with synchronous concentrations of MX in the exudate obtained from the NPWT drainage system. Serial measurements were performed upon initiation of the therapy as well as in the steady state (after 5 days). At steady state, wound tissue was obtained intraoperatively. High-performance liquid-chromatography (HPLC) was used for analysis. At 1 hour post-administration, the exudate/plasma levels (mg/L) were 1.92/3.07; at 12 hours, 0.80/1.14; at 24 hours, 0.26/0.43; and at 120 hours (steady state), 0.42/0.47. There was a correlation between exudate and plasma levels reaching approximately 0.75. Until now, methods for pharmacokinetic studies concerning interstitial fluid are difficult to apply in the clinical context. The presented method showed limitations, but we believe that, after methodological improvements, measurements of substances in the interstitial fluid by means of NPWT are feasible.
C1 [Polykandriotis, Elias] Sana Klinikum Hof, Dept Plast Hand & Microsurg, Hof, Germany.
   [Polykandriotis, Elias; Horch, Raymund E.; Arkudas, Andreas; Schmitz, Marweh] Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, Erlangen, Germany.
   [Jost, Matthias] Klinikum Nuernberg, Dept Internal Med 6, Gastrenterol, Endocrinol, Nurnberg, Germany.
   [Kees, Frieder] Univ Regensburg, Inst Pharmacol & Toxicol, Regensburg, Germany.
C3 University of Erlangen Nuremberg; Klinikum Nurnberg; University of
   Regensburg
RP Polykandriotis, E (通讯作者)，Alexander Univ Erlangen Nurnberg FAU, Acad Teaching Hosp Friedrich, Sana Klinikum Hof GmbH, Abt Plast Hand & Mikrochirurg, Eppenreuther Str 9, D-95032 Hof, Germany.
EM elias.polykandriotis@sana.de
RI Arkudas, Andreas/AAQ-6745-2021; Horch, Raymund/H-8128-2019
OI Arkudas, Andreas/0000-0002-2473-5816; Polykaniotis,
   Elias/0000-0002-8152-6420; 
FU Bayer Healthcare AG
FX Bayer Healthcare AG
CR BAGLEY DH, 1978, ANN SURG, V188, P202, DOI 10.1097/00000658-197808000-00013
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NR 27
TC 8
Z9 8
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2019
VL 16
IS 2
BP 503
EP 510
DI 10.1111/iwj.13063
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA HQ7VT
UT WOS:000462632200024
PM 30604928
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Castro, JCD
   Coltro, PS
   Jorge, JLG
   Farina, JA Jr
AF Castro, Julio C. D.
   Coltro, Pedro S.
   Jorge, Joao L. G.
   Farina Junior, Jayme A.
TI Acute otitis externa because of negative pressure wound therapy applied
   over the head and ear canal for scalping treatment
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE acute otitis externa; negative pressure wound therapy; scalp
   reconstruction; scalping
ID VACUUM-ASSISTED CLOSURE; EMERGENCY MANAGEMENT; RECONSTRUCTION;
   COMPLICATIONS; AVULSION
AB Scalping is considered a complex wound with difficult treatment, requiring early surgical intervention, reconstructive plastic surgery, and a multidisciplinary team. The reconstruction of the scalp frequently requires a combination of therapies, including temporary coverage, such as negative pressure wound therapy (NPWT). Complications of NPWT, such as bleeding, infection, and pain, have been described. However, there is no report of acute otitis externa (AOE) because of NPWT. In this article, we present an unprecedented clinical case - a female patient who developed AOE after scalping treatment with NPWT applied over the head and ear canal. We consider that it may be a result of the direct physical action of subatmospheric pressure, the presence of dressing covering the external meatus, and alteration of the bacterial population.
C1 [Castro, Julio C. D.; Coltro, Pedro S.; Jorge, Joao L. G.; Farina Junior, Jayme A.] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo
RP Coltro, PS (通讯作者)，Univ Sao Paulo, Fac Med Ribeirao Preto, Hosp Clin, Dept Cirurgia & Anat, Ave Bandeirantes 3900, BR-14048900 Ribeirao Preto, SP, Brazil.
EM pscoltro@hotmail.com
RI Farina, Jayme A/F-9518-2012; Coltro, Pedro/P-5349-2014
OI Farina, Jayme A/0000-0002-9232-367X; Coltro, Pedro/0000-0002-0164-4508
CR Assadian O, 2010, INT WOUND J, V7, P283, DOI 10.1111/j.1742-481X.2010.00686.x
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NR 23
TC 4
Z9 4
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2019
VL 16
IS 2
BP 559
EP 563
DI 10.1111/iwj.13012
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA HQ7VT
UT WOS:000462632200032
PM 30379394
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Findeisen, A
   Arefian, H
   Doenst, T
   Hagel, S
   Pletz, MW
   Hartmann, M
   Maschmann, J
AF Findeisen, Axel
   Arefian, Habibollah
   Doenst, Torsten
   Hagel, Stefan
   Pletz, Mathias W.
   Hartmann, Michael
   Maschmann, Jens
TI Economic burden of surgical site infections in patients undergoing
   cardiac surgery
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the German-Society-for-Health Economics (DGGO)
CY MAR 05-06, 2018
CL Hamburg, GERMANY
SP German Soc Hlth Econ
DE Cost; Surgical site infection; Cardiac surgery; Length of stay
ID LENGTH-OF-STAY; CARE-ASSOCIATED INFECTIONS; COST
AB OBJECTIVES This study aimed to determine the additional costs and length of stay (LOS) due to surgical site infections (SSIs) after coronary artery bypass grafting (CABG) at Jena University Hospital.
   METHODS The data of 999 consecutive patients who underwent CABG from January 2013 to December 2014 were collected. We extracted the number, type and duration of antimicrobial therapy and V.A.C.((R)) therapy (negative pressure wound therapy) treatments and calculated the additional SSI-related costs based on the hospital's perspective. We also evaluated the prolongation of LOS using a multistate model and calculated the costs due to the additional LOS.
   RESULTS In total, 983 patients were included in our analysis, and 126 patients with SSIs following CABG were identified during the study period; 124 patients with SSIs (98.4%) were discharged alive. The mean cost of antimicrobial therapy to treat the SSIs was Euro818 [95% confidence interval (CI) 392-1245], and the mean cost of V.A.C. therapy was Euro1179 (95% CI 748-1610) per infected patient. The mean additional LOS due to SSIs (standard error) was estimated to be 9.3 +/- 2.6days. The cost per SSI-infected patient attributable to the additional LOS was Euro9444 (95% CI 4242-14645).
   CONCLUSIONS SSIs following CABG are associated with an additional LOS and a significant economic burden depending on the classification of SSI. A very important component of the additional cost is the prolongation of LOS. Therefore, it is essential to shorten the hospital stay due to SSIs as far as possible.
C1 [Findeisen, Axel] Friedrich Schiller Univ Jena, Fac Med, Jena, Germany.
   [Arefian, Habibollah; Hagel, Stefan; Hartmann, Michael] Jena Univ Hosp, CSCC, Jena, Germany.
   [Arefian, Habibollah; Hartmann, Michael] Jena Univ Hosp, Hosp Pharm, Jena, Germany.
   [Doenst, Torsten] Jena Univ Hosp, Dept Cardiothorac Surg, Klinikum 1, D-07747 Jena, Germany.
   [Hagel, Stefan; Pletz, Mathias W.] Jena Univ Hosp, Inst Infect Dis & Infect Control, Jena, Germany.
   [Maschmann, Jens] Jena Univ Hosp, Jena, Germany.
C3 Friedrich Schiller University of Jena; Friedrich Schiller University of
   Jena; Friedrich Schiller University of Jena; Friedrich Schiller
   University of Jena; Friedrich Schiller University of Jena; Friedrich
   Schiller University of Jena
RP Doenst, T (通讯作者)，Jena Univ Hosp, Dept Cardiothorac Surg, Klinikum 1, D-07747 Jena, Germany.
EM doenst@med.uni-jena.de
RI Hartmann, Michael/Y-2331-2019; Arefian, Habib/AAK-3701-2020; Pletz,
   Mathias/H-9782-2019; Hagel, Stefan/AAE-1174-2022
OI Hartmann, Michael/0000-0002-6777-4540; Arefian,
   Habib/0000-0002-8838-084X; Pletz, Mathias/0000-0001-8157-2753; Hagel,
   Stefan/0000-0003-2999-6131
FU German Ministry of Education and Research (BMBF) [01EO1502]; German
   Ministry for Education and Research [01 KI 1501]
FX The Center for Sepsis Control and Care was supported by the German
   Ministry of Education and Research (BMBF) [01EO1502]; and the German
   Ministry for Education and Research [01 KI 1501 to M.B. and S.H.].
CR Allignol A, 2011, J STAT SOFTW, V38, P1
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NR 25
TC 27
Z9 35
U1 0
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD MAR
PY 2019
VL 55
IS 3
BP 494
EP 500
DI 10.1093/ejcts/ezy274
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA HQ9BJ
UT WOS:000462721200017
PM 30084908
OA Bronze
DA 2026-07-24
ER
PT J
AU Guobjartsson, T
   Jeppsson, A
AF Guobjartsson, Tomas
   Jeppsson, Anders
TI Wound infections following open heart surgery - review
SO LAEKNABLADID
LA Icelandic
DT Review
DE Wound infections; Cardiac surgery; Deep sternal wound infection;
   treatment; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; RISK-FACTORS; POSTSTERNOTOMY
   MEDIASTINITIS; POSTOPERATIVE MEDIASTINITIS; STERNOCUTANEOUS FISTULAS;
   NASAL CARRIAGE; THERAPY; MANAGEMENT; IMPACT
AB Wound infections are common complications after open heart surgery, both in the sternotomy and vein harvest wound. Fortunately, most of these infections are superficial and respond to minor wound debridement and antibiotics, however, 1-3% of patients develop deep sternal wound infection with mediastinis; an infection that can be fatal. Late infections with sternocutaneous fistulas are encountered less often, but also represent a complex surgical problem. The vein harvest site is the most common site for wound infections after cardiac surgery and these infections result in significant patient morbidity and increases health-care costs. This evidence-based review covers etiology, risk factors, prevention and treatment of wound infections following open heart surgery with special focus on advances in treatment, especially negative-pressure wound therapy.
C1 [Guobjartsson, Tomas] Landspitali Univ Hosp, Dept Cardiothorac Surg, Reykjavik, Iceland.
   [Jeppsson, Anders] Sahlgrens Univ Hosp, Dept Cardiothorac Surg, Gothenburg, Sweden.
   [Guobjartsson, Tomas] Univ Iceland, Fac Med, Reykjavik, Iceland.
C3 Landspitali National University Hospital; Sahlgrenska University
   Hospital; University of Iceland
RP Guobjartsson, T (通讯作者)，Landspitali Univ Hosp, Dept Cardiothorac Surg, Reykjavik, Iceland.; Guobjartsson, T (通讯作者)，Univ Iceland, Fac Med, Reykjavik, Iceland.
EM tomasgudbjartsson@hotmail.com
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NR 56
TC 2
Z9 2
U1 2
U2 12
PU LAEKNAFELAG ISLANDS-ICELANDIC MEDICAL ASSOC
PI KOPAVOGUR
PA HLIDASMARI 8, KOPAVOGUR, 200, ICELAND
SN 0023-7213
EI 1670-4959
J9 LAEKNABLADID
JI Laeknabladid
PY 2019
VL 105
IS 4
BP 177
EP 182
DI 10.17992/lbl.2019.04.227
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HR2UM
UT WOS:000462992900003
PM 30932876
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Eom, Y
   Woo, KJ
AF Eom, Yeseul
   Woo, Kyong-Je
TI Negative-Pressure Wound Therapy for Managing Complicated Wounds at
   Extracorporeal Membrane Oxygenation Sites
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE bacteria-binding mesh; extracorporeal membrane oxygen; lymphorrhea;
   negative-pressure wound therapy; skin necrosis; wound complications;
   wound healing; vessel exposure
ID VACUUM-ASSISTED-CLOSURE; LYMPHATIC COMPLICATIONS; BACTERIAL LOAD;
   INFECTION; GROIN; MANAGEMENT; FASCIITIS
AB OBJECTIVE: To evaluate the effectiveness of negative-pressure wound therapy (NPWT) for management of wound complications at extracorporeal membrane oxygenation (ECMO) removal sites. METHODS: The authors retrospectively reviewed patients who underwent NPWT at ECMO removal sites followed by the development of wound complications including skin necrosis, lymphorrhea, and femoral vessel exposure. A nonadhesive bacteria-binding mesh was used as a wound contact layer of NPWT application. Patient characteristics and clinical outcomes were evaluated. RESULTS: Nine patients underwent NPWT for complicated wounds at ECMO sites. The mean age of patients was 49.2 years (range, 14-64 years). All patients exhibited wound complications with lymphorrhea and skin necrosis. Seven of nine patients had wound cultures that were positive for microorganisms, but culture conversion to negative was achieved after NPWT application for a mean period of 21.2 days (range, 12-30 days). Lymphorrhea was successfully managed, and formation of fresh granulation tissue was observed in all patients. Wound healing either by primary closure, skin graft, or secondary healing was achieved without recurrence of wound complications. There were no cases of femoral vessel injury or aneurysm during NPWT application. CONCLUSIONS: Negative-pressure wound therapy appears to be a safe and effective treatment option in the management of complicated wounds at ECMO sites.
C1 [Eom, Yeseul] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Plast Surg, Seoul, South Korea.
   [Woo, Kyong-Je] Ewha Womans Univ, Coll Med, Mokdong Hosp, Dept Plast Surg, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Ewha Womans
   University
RP Eom, Y (通讯作者)，Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Plast Surg, Seoul, South Korea.
RI Woo, KyongJe/IRZ-3509-2023
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NR 30
TC 3
Z9 5
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD APR
PY 2019
VL 32
IS 4
BP 183
EP 189
DI 10.1097/01.ASW.0000553596.11034.d7
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA HR5OO
UT WOS:000463196600006
PM 30889018
DA 2026-07-24
ER
PT J
AU Clifford, RE
   Fowler, H
   Govindarajah, N
   Vimalachandran, D
   Sutton, PA
AF Clifford, R. E.
   Fowler, H.
   Govindarajah, N.
   Vimalachandran, D.
   Sutton, P. A.
TI Early anastomotic complications in colorectal surgery: a systematic
   review of techniques for endoscopic salvage
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Review
DE Colorectal; Anastomotic leak; Stricture; Colonoscopy; Endoscopy
ID VACUUM-ASSISTED CLOSURE; ENDO-SPONGE TREATMENT; MESORECTAL EXCISION;
   ANTERIOR RESECTION; RECTAL-CANCER; LEAKAGE; MANAGEMENT; THERAPY; STENTS;
   EXPERIENCE
AB BackgroundAnastomotic complications following colorectal surgery are associated with significant morbidity and mortality. For patients in whom systemic sepsis is absent or well controlled, minimal access techniques, such as endoscopic therapies, are being increasingly employed to reduce the morbidity of surgical re-intervention. In this review, we aim to assess the utility of endoscopic management in the acute setting of colorectal anastomotic complications, focusing on anastomotic leak.MethodA literature search was performed for published full text articles using the PubMed, Cochrane and Scopus databases using the search criteria string colorectal anastomotic (leak OR bleed), endoscopy, endoscopic management. Additional papers were detected by scanning the references of relevant papers. Data were extracted from each study by two authors onto a dedicated pro-forma. Given the nature of the data extracted, no meta-analysis was performed.ResultsA total of 89 papers were identified, 16 of which were included in this review; an additional 14 papers were obtained from reference searches. In patients who are not physiologically compromised, there are promising data regarding the salvage rate of stents, over-the-scope endoscopic clips, vacuum therapy and fibrin glue in the early management of colorectal anastomotic leak. There is no consensus regarding the optimal approach, and data to assist the physician in patient selection are lacking. Whilst data on salvage (i.e. healing and avoidance of surgery) are well understood, no data on functional outcomes are reported.ConclusionEndoscopic therapy in the management of stable patients with colorectal anastomotic leaks appears safe and in selected patients is associated with high rates of technical success. Challenges remain in selecting the most appropriate strategy, patient selection, and understanding the functional and long-term sequelae of this approach. Further evidence from large prospective cohort studies are needed to further evaluate the role of these novel strategies.
EM rachael.clifford@liverpool.ac.uk
RI ; vimalachandran, dale/J-5693-2019
OI Sutton, Paul/0000-0002-7452-0282; vimalachandran,
   dale/0000-0001-5817-8969; Govindarajah, Naren/0000-0002-1417-2220;
   Clifford, Rachael/0000-0001-7065-0197
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NR 55
TC 35
Z9 46
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD APR
PY 2019
VL 33
IS 4
BP 1049
EP 1065
DI 10.1007/s00464-019-06670-9
PG 17
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HR5YL
UT WOS:000463223600004
PM 30675662
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Ibrahim, ZM
   Waked, IS
   Ibrahim, O
AF Ibrahim, Zizi M.
   Waked, Instar S.
   Ibrahim, Olfat
TI Negative pressure wound therapy versus microcurrent electrical
   stimulation in wound healing in burns
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE burn injury; microcurrent electrical stimulation; negative pressure
   wound therapy; wound healing
ID VACUUM-ASSISTED CLOSURE; LASER IRRADIATION; INJURY; COST; LOAD
AB Objective: To compare the efficacy of negative pressure wound therapy (NPWT) with that of microcurrent electrical stimulation (MES) on wound surface area, length of stay (LoS) and colony count of wounds in patients with burns.
   Method: Patients with thermal dermal burn injuries covering 25-40% of total body surface area were enrolled in this clinical trial. Participants were randomly allocated into three, equal-sized groups: patients receiving NPWT, patients receiving MES and a control group which received standard wound care. All groups received the same traditional physical therapy programme in addition to the same nursing and medical care. In all groups, wound surface area, colony count and LoS were measured 72 hours after thermal burn injury (pre), after 10 days and again at 21 days from the beginning of the study.
   Results: A total of 45 patients took part in the study. There were statistically significant decreases in wound surface area observed in all groups (p<0.05) while MES showed the highest mean percentage of reduction in wound surface. MES and NPWT both showed the lowest values for bacterial growth but NPWT was superior in colony count reduction. For LoS, both MES and NPWT showed the lowest mean value.
   Conclusion: From the findings of this study, MES was more effective in decreasing wound surface area in burn wounds while NPWT was more effective in reducing bacterial growth.
C1 [Ibrahim, Zizi M.; Waked, Instar S.] Cairo Univ, Fac Phys Therapy, Dept Phys Therapy Surg, Giza, Egypt.
   [Ibrahim, Zizi M.] Princess Nourah Bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Rehabil Sci Dept, Riyadh, Saudi Arabia.
   [Ibrahim, Olfat] Cairo Univ, Fac Phys Therapy, Dept Basic Sci Phys Therapy, Giza, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Princess Nourah bint
   Abdulrahman University; Egyptian Knowledge Bank (EKB); Cairo University
RP Ibrahim, ZM (通讯作者)，Cairo Univ, Fac Phys Therapy, Dept Phys Therapy Surg, Giza, Egypt.; Ibrahim, ZM (通讯作者)，Princess Nourah Bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Rehabil Sci Dept, Riyadh, Saudi Arabia.
EM zizikahla@yahoo.com
RI Ibrahim Ali, Olfat/M-7832-2019; /AAF-1738-2021; IBRAHIM,
   ZIZI/AAA-8191-2020
OI Ibrahim Ali, Olfat/0000-0003-4279-3662; 
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   Liu Y., 2014, PLOS ONE, V9
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NR 36
TC 26
Z9 32
U1 0
U2 32
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2019
VL 28
IS 4
BP 214
EP 219
DI 10.12968/jowc.2019.28.4.214
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HS0UA
UT WOS:000463574700005
PM 30975055
DA 2026-07-24
ER
PT J
AU Kocaaslan, FND
   Ozkan, MC
   Akdeniz, Z
   Sacak, B
   Erol, B
   Yuksel, M
   Celebiler, O
AF Kocaaslan, Fatma Nihal Durmus
   Ozkan, Melekber Cavus
   Akdeniz, Zeynep
   Sacak, Bulent
   Erol, Bulent
   Yuksel, Mustafa
   Celebiler, Ozhan
TI Use of abdominal negative pressure wound therapy in different
   indications: a case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE abdominal negative pressure wound therapy; ABThera; vacuum assisted
   closure therapy
ID VACUUM-ASSISTED CLOSURE; VAC(R) THERAPY; POSTPNEUMONECTOMY; MANAGEMENT;
   DEVICE; RISK
AB Negative pressure wound therapy (NPWT) is a widely used wound management system. Several articles have been published on the advantages and complications of this system. Abdominal dressing negative pressure system (abdominal NPWT) is a newer technology, developed and used in open abdomen cases. The adherence of the sponge to the intra-abdominal organs is prevented by a polyurethane foam. This study presents a number of case series where an abdominal NPWT (ABThera, KCl, US) has been used to treat other vital organs, helping to prevent complications such as organ rupture and fatal bleeding.
C1 [Kocaaslan, Fatma Nihal Durmus; Ozkan, Melekber Cavus; Akdeniz, Zeynep; Sacak, Bulent; Celebiler, Ozhan] Marmara Univ, Sch Med, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkey.
   [Erol, Bulent] Marmara Univ, Sch Med, Dept Orthoped & Traumatol, Istanbul, Turkey.
   [Yuksel, Mustafa] Marmara Univ, Sch Med, Dept Thorax Surg, Istanbul, Turkey.
C3 Marmara University; Marmara University; Marmara University
RP Kocaaslan, FND (通讯作者)，Marmara Univ, Sch Med, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkey.
EM dr-nihal@hotmail.com
RI akdeniz, zeynep/AAK-9450-2021; Erol, Bulent/AAG-2982-2021; Çavuş Özkan,
   Melekber/AGH-4064-2022
OI Erol, Bulent/0000-0001-7099-6374; 
CR Al-Mufarrej F, 2010, SURG TODAY, V40, P711, DOI 10.1007/s00595-008-4096-9
   Babiak Ireneusz, 2011, Chir Narzadow Ruchu Ortop Pol, V76, P154
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   Caro A, 2011, INT WOUND J, V8, P274, DOI 10.1111/j.1742-481X.2011.00782.x
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   Gupta S, 2004, WOUNDS, p26S
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NR 24
TC 4
Z9 4
U1 0
U2 10
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2019
VL 28
IS 4
BP 240
EP 244
DI 10.12968/jowc.2019.28.4.240
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HS0UA
UT WOS:000463574700008
PM 30975060
DA 2026-07-24
ER
PT J
AU Verstegen, MHP
   Bouwense, SAW
   van Workum, F
   ten Broek, R
   Siersema, PD
   Rovers, M
   Rosman, C
AF Verstegen, Moniek H. P.
   Bouwense, Stefan A. W.
   van Workum, Frans
   ten Broek, Richard
   Siersema, Peter D.
   Rovers, Maroeska
   Rosman, Camiel
TI Management of intrathoracic and cervical anastomotic leakage after
   esophagectomy for esophageal cancer: a systematic review
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Anastomotic; Leakage; Intrathoracic; Cervical; Esophagectomy; Treatment
ID STENT; COMPLICATIONS; PLACEMENT; DIAGNOSIS; DILATION; SURGERY; TUBE
AB BackgroundAnastomotic leakage (0-30%) after esophagectomy is a severe complication and is associated with considerable morbidity and mortality. The aim of this study was to determine which treatment for anastomotic leakage after esophagectomy have the best clinical outcome, based on the currently available literature.MethodsA systematic literature search was performed in Medline, Embase, and Web of Science until April 2017. All studies reporting on the specific treatment of cervical or intrathoracic anastomotic leakage following esophagectomy with gastric tube reconstruction for esophageal or cardia cancer were included. The primary outcome parameter was postoperative mortality. Methodological quality was assessed by the Newcastle-Ottawa Quality Assessment Scale.ResultsNineteen retrospective cohort studies including 273 patients were identified. Methodological quality of all studies was poor to moderate. Mortality rates of intrathoracic anastomotic leakages in the treatment groups were as follows: conservative (14%), endoscopic stent (8%), endoscopic drainage (8%), endoscopic vacuum-assisted closure system (0%), and surgery treatment group (50%). Mortality rates of cervical anastomotic leakages in the treatment groups were as follows: conservative (8%), endoscopic stent (29%), and endoscopic dilatation (0%).DiscussionDue to small cohorts, heterogeneity between studies, and lack of data regarding leakage characteristics, no evidence supporting a specific treatment for anastomotic leakage after esophagectomy was found. A severity score based on leakage characteristics instead of treatment given is essential for determining the optimal treatment of anastomotic leakage. In the absence of robust evidence-based treatment guidelines, we suggest customized treatment depending on sequelae of the leak and clinical condition of the patient. PrDepartment of Surgery, Radboudumc, P.O.B. 9101/618 NLactical advices are provided.Trial registrationRegistration number PROSPERO: CRD42016032374.
C1 [Verstegen, Moniek H. P.; Bouwense, Stefan A. W.; van Workum, Frans; ten Broek, Richard; Rosman, Camiel] Radboudumc, Dept Surg, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands.
   [Siersema, Peter D.] Radboudumc, Gastroenterol & Hepatol, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands.
   [Rovers, Maroeska] Radboudumc, Operating Rooms & Hlth Evidence, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Radboud
   University Nijmegen
RP Verstegen, MHP (通讯作者)，Radboudumc, Dept Surg, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands.
EM moniek.verstegen@radboudumc.nl
RI ; rosman, camiel/F-9059-2016; Bouwense, Stefan/P-6468-2015; Broek,
   Richard/M-9038-2016; Rovers, Maroeska/F-2969-2014; Siersema,
   Peter/V-1636-2019; van Workum, Frans/F-9311-2016
OI Verstegen, Moniek/0000-0002-8371-509X; rosman,
   camiel/0000-0002-9152-3987; Bouwense, Stefan/0000-0002-7600-9429;
   Rovers, Maroeska/0000-0002-3095-170X; 
CR Al-Issa MA, 2014, SAUDI J GASTROENTERO, V20, P39, DOI 10.4103/1319-3767.126315
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   [Anonymous], 2019, TREATMENT ANASTOMOTI
   [Anonymous], 2015, PROSPERO
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NR 36
TC 76
Z9 89
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD APR 4
PY 2019
VL 14
AR 17
DI 10.1186/s13017-019-0235-4
PG 12
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA HS1UB
UT WOS:000463646500001
PM 30988695
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Knight, R
   Spoors, LM
   Costa, ML
   Dutton, SJ
AF Knight, Ruth
   Spoors, Louise M.
   Costa, Matthew L.
   Dutton, Susan J.
TI Wound Healing In Surgery for Trauma (WHIST): statistical analysis plan
   for a randomised controlled trial comparing standard wound management
   with negative pressure wound therapy
SO TRIALS
LA English
DT Article
DE Statistical analysis plan; Randomised controlled trial; Negative
   pressure wound therapy; Lower extremity trauma; Surgical site infection
ID TIBIAL PLAFOND; FRACTURES; DISABILITY; FIXATION
AB BackgroundIn the context of major trauma, the rate of wound infection in surgical incisions created during fracture fixation amongst patients with closed high-energy injuries is high. One of the factors which may reduce the risk of surgical site infection is the type of dressing applied over the closed incision. The WHIST trial evaluates the effects of negative-pressure wound therapy (NPWT) compared with standard dressings.Methods/designThe WHIST trial is a multicentre, parallel group, randomised controlled trial. The primary outcome is the rate of deep surgical site infection at 30days after major trauma. Secondary outcomes are measured at 3 and 6months post-randomisation and include the Disability Rating Index, the EuroQoL EQ-5D-5L, the Doleur Neuropathique Questionnaire, a patient-reported scar assessment, and record of complications. The analysis approaches for the primary and secondary outcomes are described here, as are the descriptive statistics which will be reported. The full WHIST protocol has already been published.DiscussionThis paper provides details of the planned statistical analyses for this trial and will reduce the risks of outcome reporting bias and data driven results.Trial registrationInternational Standard Randomised Controlled Trials database, ISRCTN12702354. Registered on 9 December 2015.
C1 [Knight, Ruth; Dutton, Susan J.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Ctr Stat Med, Oxford Clin Trials Res Unit, Windmill Rd, Oxford OX3 7LD, England.
   [Spoors, Louise M.; Costa, Matthew L.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
C3 University of Oxford; University of Oxford
RP Knight, R (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Ctr Stat Med, Oxford Clin Trials Res Unit, Windmill Rd, Oxford OX3 7LD, England.
EM ruth.knight@csm.ox.ac.uk
OI Costa, Matthew/0000-0003-3644-1388; Knight, Ruth/0000-0001-6810-2845;
   Dutton, Susan/0000-0003-4573-5257
FU UK National Institute for Health Research Health Technology Assessment
   (HTA) programme [14/199/14]; National Institute for Health Research
   (NIHR) Oxford Biomedical Research Centre; National Institute for Health
   Research [14/199/14] Funding Source: researchfish
FX This project was funded by the UK National Institute for Health Research
   Health Technology Assessment (HTA) programme (project number 14/199/14)
   and was supported by the National Institute for Health Research (NIHR)
   Oxford Biomedical Research Centre. The funder has not been involved in
   the design of the study. The views expressed are those of the authors
   and not necessarily those of the NHS, the NIHR or the Department of
   Health.
CR Achten J, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-022115
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NR 28
TC 13
Z9 14
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD MAR 28
PY 2019
VL 20
AR 186
DI 10.1186/s13063-019-3282-y
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HS2HB
UT WOS:000463680600002
PM 30922364
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chen, XQ
   Li, J
   Li, QY
   Zhang, W
   Lei, ZJ
   Qin, DY
   Pan, ZP
   Li, JQ
   Li, XY
AF Chen, Xiaoqiang
   Li, Jing
   Li, Qiaoying
   Zhang, Wei
   Lei, Zhanjun
   Qin, Danying
   Pan, Zeping
   Li, Jinqing
   Li, Xueyong
TI Spatial-Temporal Changes of Mechanical Microenvironment in Skin Wounds
   During Negative Pressure Wound Therapy
SO ACS BIOMATERIALS SCIENCE & ENGINEERING
LA English
DT Article
DE NPWT; mechanical microenvironment; shear wave elastography; finite
   element analysis
ID VACUUM-ASSISTED CLOSURE; IN-VIVO; CELL MORPHOLOGY; TISSUE; STIFFNESS;
   STRAIN; MORPHOGENESIS; MULTICENTER; MIGRATION; HYDROGELS
AB Cell migration, proliferation, and differentiation are regulated by mechanical cues during skin wound healing. Negative pressure wound therapy (NPWT) reduces the healing period by optimizing the mechanical micro environment of the wound bed. Under NPWT, it remains elusive how the mechanical microenvironment (e.g., stiffness, strain gradients) changes both in time and space during wound healing. To illustrate this, the healing time of full thickness skin wounds under NPWT, with pressure settings ranging from -50 to -150 mm Hg, were evaluated and compared with gauze dressing treatments (control group), and three-dimensional finite element models of full-thickness skin wounds on days 1 and 5 after treatment were developed on the basis of MR 3D imaging data. Shear wave elastography (SWE) was applied to detect the stiffness of wound soft tissue on days 1 and 5, and nonlinear finite element analysis (FEA) was used to represent the spatial temporal environment of the 3D strain field of the wound under NPWT vs the control group. Compared with the control group, NPWT with -50, -80, and -125 mm Hg promoted wound healing. SWE showed that the elastic modulus of wounded skin increased during healing. Meanwhile, the elastic modulus in wounded skin under NPWT was significantly smaller than in the control group. Strain and its gradient decreased under NPWT during wound healing, while no significant change was observed in the control group. This study, which is based on MR 3D imaging, shear wave elastography, and nonlinear FEA, provides an in-depth understanding of changes of the skin mechanical microenvironment under NPWT in the time-space dimension and the associated wound healing.
C1 [Chen, Xiaoqiang; Li, Jing; Lei, Zhanjun; Qin, Danying; Pan, Zeping; Li, Jinqing; Li, Xueyong] Fourth Mil Med Univ, Tangdu Hosp, Dept Plast & Burn Surg, 1 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China.
   [Li, Qiaoying] Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasonog, 1 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China.
   [Zhang, Wei] Fourth Mil Med Univ, Tangdu Hosp, Dept Radiol & Nucl Med, 1 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University
RP Li, JQ; Li, XY (通讯作者)，Fourth Mil Med Univ, Tangdu Hosp, Dept Plast & Burn Surg, 1 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China.
EM lijqfmmu@hotmail.com; lixueyong641123@163.com
RI ; Pan, Zeping/JVZ-2118-2024
OI XIAOQIANG, CHEN/0000-0002-0926-9546; 
FU National Science Foundation of China [81671929, 81272134]; Natural
   Science Foundation of Shaanxi Province [2014JM4128]
FX This study was financially supported by the National Science Foundation
   of China (81671929, 81272134) and the Natural Science Foundation of
   Shaanxi Province (2014JM4128). The authors acknowledge all of their
   colleagues at the Department of Burn and Plastic Surgery, Tangdu
   Hospital, Fourth Military Medical University, for their full cooperation
   and support. The same thanks are also given for the guidance and
   suggestions from Professor Feng Xu and Shaobao Liu, Yuhui Li, and Yufei
   Ma from the Bioinspired Engineering and Biomechanics Center (BEBC),
   Xi'an Jiaotong University.
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NR 56
TC 18
Z9 20
U1 2
U2 36
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2373-9878
J9 ACS BIOMATER SCI ENG
JI ACS Biomater. Sci. Eng.
PD APR
PY 2019
VL 5
IS 4
BP 1762
EP 1770
DI 10.1021/acsbiomaterials.8b01554
PG 17
WC Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA HT0FQ
UT WOS:000464241400011
PM 33405552
DA 2026-07-24
ER
PT J
AU Bakaeen, FG
   Haddad, O
   Ibrahim, M
   Pasadyn, SR
   Germano, E
   Mok, S
   Halbreiner, MS
   McCurry, KR
   Johnston, DR
   Mick, SL
   Navia, JL
   Roselli, EE
   Smedira, NG
   Soltesz, EG
   Tong, MZ
   Wierup, P
   Gillinov, AM
   Svensson, LG
   Houghtaling, PL
   Blackstone, EH
   Pettersson, GB
AF Bakaeen, Faisal G.
   Haddad, Osama
   Ibrahim, Mudathir
   Pasadyn, Selena R.
   Germano, Emidio
   Mok, Salvior
   Halbreiner, M. Scott
   McCurry, Kenneth R.
   Johnston, Douglas R.
   Mick, Stephanie L.
   Navia, Jose L.
   Roselli, Eric E.
   Smedira, Nicholas G.
   Soltesz, Edward G.
   Tong, Michael Z.
   Wierup, Per
   Gillinov, A. Marc
   Svensson, Lars G.
   Houghtaling, Penny L.
   Blackstone, Eugene H.
   Pettersson, Gosta B.
TI Advances in managing the noninfected open chest after cardiac surgery:
   Negative-pressure wound therapy
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 98th Annual Meeting of the American-Association-for-Thoracic-Surgery
   (AATS)
CY APR 28-MAY 18, 2018
CL San Diego, CA
SP Amer Assoc Thorac Surg
DE hemodynamics; coagulopathy; survival; propensity score
ID DELAYED STERNAL CLOSURE; VACUUM-ASSISTED CLOSURE; STERNOTOMY; INFECTION;
   TRANSFUSION; COMPRESSION; HEMORRHAGE; TAMPONADE; RISK
AB Objective: The objective of this study was to compare safety and clinical effectiveness of negative-pressure wound therapy (NPWT) with traditional wound therapy for managing noninfected open chests with delayed sternal closure after cardiac surgery.
   Methods: From January 2000 to July 2015, 452 of 47,325 patients who underwent full sternotomy left the operating room with a noninfected open chest (0.96%), managed using NPWT in 214-with frequency of use rapidly increasing to near 100%-and traditionally in 238. Predominant indications for open-chest management were uncontrolled coagulopathy or hemodynamic compromise on attempted chest closure. Weighted propensity-score matching was used to assess in-hospital complications and time-related survival.
   Results: NPWT and traditionally managed patients had similar high-risk preoperative profiles. Most underwent reoperations (63% of the NPWT group and 57% of the traditional group), and 21% versus 25% were emergency procedures. Reexplorations for bleeding were less common with NPWT versus traditional wound therapy (n = 63 [29%] vs 104 [44%], P =.002). Median duration of open-chest to definitive sternal closure was 3.5 days for NPWT versus 3.1 for traditionally managed patients (P[log rank] =.07). Seven patients (3.3%) were converted from NPWT to traditional therapy because of hemodynamic intolerance and 6 (2.5%) from traditional to NPWT. No NPWT-related cardiovascular injuries occurred. Among matched patients, NPWT was associated with better early survival (61% vs 44% at 6 months; P =.02).
   Conclusions: NPWT is safe and effective for managing noninfected open chests after cardiac surgery. By facilitating open-chest management and potentially improving outcomes, it has become our therapy of choice and perhaps has lowered our threshold for leaving the chest open after cardiac surgery.
C1 [Bakaeen, Faisal G.; Haddad, Osama; Ibrahim, Mudathir; Pasadyn, Selena R.; Germano, Emidio; Mok, Salvior; Halbreiner, M. Scott; McCurry, Kenneth R.; Johnston, Douglas R.; Mick, Stephanie L.; Navia, Jose L.; Roselli, Eric E.; Smedira, Nicholas G.; Soltesz, Edward G.; Tong, Michael Z.; Wierup, Per; Gillinov, A. Marc; Svensson, Lars G.; Blackstone, Eugene H.; Pettersson, Gosta B.] Cleveland Clin, Dept Thorac & Cardiovasc Surg, Inst Heart & Vasc, Cleveland, OH 44106 USA.
   [Houghtaling, Penny L.; Blackstone, Eugene H.] Cleveland Clin, Dept Quantitat Hlth Sci, Res Inst, Cleveland, OH 44106 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation
RP Pettersson, GB (通讯作者)，Cleveland Clin, Dept Thorac & Cardiovasc Surg, 9500 Euclid Ave Desk J4-1, Cleveland, OH 44915 USA.
EM petterg@ccf.org
RI ; IBRAHIM, MUDATHIR/AAZ-1557-2020; Haddad, Osama/AAY-3238-2021; mok,
   salvior/NBY-2568-2025; Svensson, Lars/ABY-1869-2022
OI Blackstone, Eugene/0000-0001-9839-3567; IBRAHIM,
   MUDATHIR/0000-0002-6345-1533; , Sal/0009-0009-0183-2048; Haddad,
   Osama/0000-0001-6308-6372; 
FU Gus P. Karos Registry Fund; David Whitmire Hearst, Jr. Foundation; Marty
   and Michelle Weinberg and Family Fund; Sheikh Hamdan bin Rashid Al
   Maktoum Distinguished Chair in Thoracic and Cardiovascular Surgery;
   Stephens Family Endowed Chair in Cardiothoracic Surgery; Delos M.
   Cosgrove, MD, Chair for Heart Disease Research; Drs Sidney and Becca
   Fleischer Heart and Vascular Education Chair; Peter and Elizabeth C.
   Tower and Family Endowed Chair in Cardiothoracic Research; Slosburg
   Family Charitable Trust
FX This study was funded in part by the Gus P. Karos Registry Fund, the
   David Whitmire Hearst, Jr. Foundation, the Marty and Michelle Weinberg
   and Family Fund, the Sheikh Hamdan bin Rashid Al Maktoum Distinguished
   Chair in Thoracic and Cardiovascular Surgery, the Stephens Family
   Endowed Chair in Cardiothoracic Surgery, the Delos M. Cosgrove, MD,
   Chair for Heart Disease Research, the Drs Sidney and Becca Fleischer
   Heart and Vascular Education Chair, the Peter and Elizabeth C. Tower and
   Family Endowed Chair in Cardiothoracic Research, James and Sharon
   Kennedy, the Slosburg Family Charitable Trust, Stephen and Saundra
   Spencer, and Martin Nielsen.
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NR 35
TC 19
Z9 22
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD MAY
PY 2019
VL 157
IS 5
BP 1891
EP +
DI 10.1016/j.jtcvs.2018.10.152
PG 21
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA HT3AY
UT WOS:000464437100077
PM 30709676
OA Bronze
DA 2026-07-24
ER
PT J
AU Webb, MA
   Bleszynski, MS
   Chen, L
   Chiu, J
   Meneghetti, A
   Panton, ON
AF Webb, Mitchell A.
   Bleszynski, Michael S.
   Chen, Leo
   Chiu, Jack
   Meneghetti, Adam
   Panton, Ormond N.
TI Incisional wound VAC and risk-adjusted SSI rates in colorectal surgery:
   A tertiary centre experience
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID SURGICAL-SITE INFECTIONS; NEGATIVE-PRESSURE THERAPY; AMERICAN-COLLEGE;
   LAPAROTOMY; PREVENTION; METAANALYSIS; CALCULATOR; TRIAL
AB Background: In colorectal surgery, indications for incisional negative pressure wound therapy (iVAC) remain unclear. We sought to compare rates of surgical site infection (SSI) in patients who received iVAC or standard sterile dressing (SSD).
   Methods: Institutional colorectal NSQIP data between 2014 and 2018 was reviewed. SSI rates were compared between iVAC and SSD cohorts using the NSQIP surgical risk calculator (NSQIP SRC) for risk-adjusted analysis. Secondary outcomes included other wound complications, morbidity, mortality, disposition destination and overall length of stay.
   Results: 145 patients received iVAC while 544 received SSD. SSI was greater in iVAC than SSD (17% vs 9%, p = 0.009). iVAC was independently associated with SSI (OR 2.3, 95% CI 1.3-3.9). The presence of a colostomy strengthened this relationship. There was no difference in secondary outcomes.
   Conclusion: iVAC was independently associated with SSI with risk-adjusted analysis. This relationship was stronger in patients with a colostomy. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Webb, Mitchell A.; Bleszynski, Michael S.; Chen, Leo; Chiu, Jack; Meneghetti, Adam; Panton, Ormond N.] Univ British Columbia, Dept Surg, Div Gen Surg, 2775 Laurel St,11th Floor, Vancouver, BC V5Z 1M9, Canada.
C3 University of British Columbia
RP Webb, MA (通讯作者)，Univ British Columbia, Dept Surg, Div Gen Surg, 2775 Laurel St,11th Floor, Vancouver, BC V5Z 1M9, Canada.
EM Mitchell.webb@alumni.ubc.ca
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NR 33
TC 8
Z9 8
U1 0
U2 6
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2019
VL 217
IS 5
SI SI
BP 948
EP 953
DI 10.1016/j.amjsurg.2018.12.019
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HT4CY
UT WOS:000464512000026
PM 30612695
DA 2026-07-24
ER
PT J
AU Riedl, JC
   Gericke, A
   Engelmann, J
   Vossmerbaeumer, U
AF Riedl, J. C.
   Gericke, A.
   Engelmann, J.
   Vossmerbaeumer, U.
TI Self-inflicted eye injury
SO OPHTHALMOLOGE
LA German
DT Article
DE Borderline personality disorder; Self-injurious behavior; Vacuum
   assisted closure; Eyelid abscess; Eyeball reconstruction
ID PREVALENCE
AB Self-injurious behavior (nonsuicidal self-injury, NNSI) is acommon phenomenon and occurs in Germany, especially in adolescence, with alifetime prevalence of 25-35%. In adulthood autoaggressive behavior is usually associated with mental illness, such as borderline personality disorder, as in the presented case. Eye injuries are rare. The treating physician is faced with the difficulty of correctly classifying the injury and clarifying suicidal intentions. Patient care requires alot of patience, empathy and time and has to include psychosocial aspects.
C1 [Riedl, J. C.; Gericke, A.; Vossmerbaeumer, U.] Univ Med Mainz, Augenklin & Poliklin, Langenbeckstr 1, D-55131 Mainz, Germany.
   [Engelmann, J.] Univ Med Mainz, Klin Psychiat & Psychotherapie, Mainz, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz
RP Riedl, JC (通讯作者)，Univ Med Mainz, Augenklin & Poliklin, Langenbeckstr 1, D-55131 Mainz, Germany.
EM Jana.Riedl@unimedizin-mainz.de
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NR 8
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0941-293X
EI 1433-0423
J9 OPHTHALMOLOGE
JI Ophthalmologe
PD APR
PY 2019
VL 116
IS 4
BP 372
EP 375
DI 10.1007/s00347-018-0740-y
PG 4
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Ophthalmology
GA HT9BA
UT WOS:000464858200011
PM 29881876
DA 2026-07-24
ER
PT J
AU Min, YW
   Kim, T
   Lee, H
   Min, BH
   Kim, HK
   Choi, YS
   Lee, JH
   Rhee, PL
   Kim, JJ
   Zo, JI
   Shim, YM
AF Min, Yang Won
   Kim, Taewan
   Lee, Hyuk
   Min, Byung-Hoon
   Kim, Hong Kwan
   Choi, Yong Soo
   Lee, Jun Haeng
   Rhee, Poong-Lyul
   Kim, Jae J.
   Zo, Jae Ill
   Shim, Young Mog
TI Endoscopic vacuum therapy for postoperative esophageal leak
SO BMC SURGERY
LA English
DT Article
DE Endoscopic vacuum-assisted closure; Esophagectomy; Leak
ID ANASTOMOTIC LEAK; ASSISTED CLOSURE; MANAGEMENT; STENT; COMPLICATIONS
AB Background: Anastomotic leak is the most common and serious complication following esophagectomy. Endoscopic vacuum-assisted closure (EVAC) is a promising method for treating anastomotic leak. We aimed to evaluate the efficacy of EVAC and to identify factors associated with longer treatment duration for esophageal anastomotic leak following esophagectomy for cancer.
   Methods: We retrospectively analyzed 20 esophageal cancer patients who had undergone EVAC for anastomotic leak after esophagectomy. The efficacy and success rates were evaluated and factors associated with longer treatment duration (>= 21 days) were identified.
   Results: All 20 patients were male. Of these, 10 (50.0%) received neoadjuvant treatment and 6 (30.0%) had one or more comorbidities. The median size of fistula opening was 1.75 cm. During a median of 14.5 days of EVAC treatment, a median of 5 interventions were performed. Treatment success was achieved in 19 patients (95.0%). Neoadjuvant treatment was significantly associated with longer EVAC treatment. There was a non-significant trend toward the need for longer treatment duration for a larger fistula opening size.
   Conclusions: EVAC treatment is a good non-surgical option for anastomotic leak following esophagectomy. Long duration of treatment is associated with neoadjuvant treatment and a large leakage opening.
C1 [Min, Yang Won; Kim, Taewan; Lee, Hyuk; Min, Byung-Hoon; Lee, Jun Haeng; Rhee, Poong-Lyul; Kim, Jae J.] Sungkyunkwan Univ, Dept Med, Samsung Med Ctr, Sch Med, Seoul, South Korea.
   [Kim, Hong Kwan; Choi, Yong Soo; Zo, Jae Ill; Shim, Young Mog] Sungkyunkwan Univ, Dept Thorac & Cardiovasc Surg, Samsung Med Ctr, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center
RP Zo, JI (通讯作者)，Sungkyunkwan Univ, Dept Thorac & Cardiovasc Surg, Samsung Med Ctr, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea.
EM yangwonee@gmail.com; jayl.zo@samsung.com
RI ; Rhee, Poong/C-9655-2011
OI Min, Yang Won/0000-0001-7471-1305; Choi, Yong Soo/0000-0002-2552-0067;
   Min, Byung-Hoon/0000-0001-8048-361X; 
FU National R&D Program for Cancer Control, Ministry of Health Welfare,
   Korea [1720180]
FX Professor Jae Ill Zo, who coordinated the study and edited the
   manuscript, was supported by the following grant(s): The National R&D
   Program for Cancer Control, Ministry of Health & Welfare, Korea
   (1720180).
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Chen KN, 2014, J THORAC DIS, V6, pS355, DOI 10.3978/j.issn.2072-1439.2014.03.36
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   Hwang JJ, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003416
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   Turkyilmaz A, 2009, DIS ESOPHAGUS, V22, P119, DOI 10.1111/j.1442-2050.2008.00866.x
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   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Whooley BP, 2001, AM J SURG, V181, P198, DOI 10.1016/S0002-9610(01)00559-1
   Zisis C, 2008, EUR J CARDIO-THORAC, V33, P451, DOI 10.1016/j.ejcts.2007.12.020
NR 23
TC 54
Z9 60
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD APR 11
PY 2019
VL 19
AR 37
DI 10.1186/s12893-019-0497-5
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HT9JY
UT WOS:000464886800002
PM 30975210
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tartaglia, D
   Costa, G
   Camillò, A
   Castriconi, M
   Andreano, M
   Lanza, M
   Fransvea, P
   Ruscelli, P
   Rimini, M
   Galatioto, C
   Chiarugi, M
AF Tartaglia, Dario
   Costa, Gianluca
   Camillo, Antonio
   Castriconi, Maurizio
   Andreano, Mauro
   Lanza, Michele
   Fransvea, Pietro
   Ruscelli, Paolo
   Rimini, Massimiliano
   Galatioto, Christian
   Chiarugi, Massimo
TI Damage control surgery for perforated diverticulitis with diffuse
   peritonitis: saves lives and reduces ostomy
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Complicated diverticulitis; Damage control surgery; Observational study
ID ACUTE COLONIC DIVERTICULITIS; HARTMANNS PROCEDURE; PRIMARY ANASTOMOSIS;
   EMERGENCY-SURGERY; RESECTION; CLASSIFICATION; MANAGEMENT
AB IntroductionOver the last decade, damage control surgery (DCS) has been emerging as a feasible alternative for the management of patients with abdominal infection and sepsis. So far, there is no consensus about the role of DCS for acute perforated diverticulitis. In this study, we present the outcome of a multi-institutional series of patients presenting with Hinchey's grade III and IV diverticulitis managed by DCS.MethodsAll the participating centers were tertiary referral hospitals. A total of 34 patients with perforated diverticulitis treated with DCS during the period 2011-2017 were included in the study. During the first laparotomy, a limited resection of the diseased segment was performed followed by lavage and use of negative pressure wound therapy (NPWT). After 24/48h of resuscitation, patients returned to the operating room for a second look. Mortality, morbidity, and restoration of bowel continuity were the primary outcomes of the study.ResultsThere were 15 males (44%) and 19 females (56%) with a mean age of 66.9years (SD12.7). Mean BMI was 28.42kg/m(2) (SD +/- 3.33). Thirteen cases (38%) were Wasvary's modified Hinchey's stage III, and 21 cases (62%) Hinchey's stage IV. Mean Mannheim Peritonitis Index (MPI) was 25.12 (SD +/- 6.28). In 22 patients (65%), ASA score was grade III. Twenty-four patients (71%) had restoration of bowel continuity, while 10 (29%) patients had an end colostomy (Hartmann's procedure). Three of these patients received a temporary loop ileostomy. One patient had an anastomotic leak. Mortality rate was 12%. Mean length of hospital stay was 21.9days. At multivariate analysis, male gender (p=0.010) and MPI (p=0.034) correlated with a high percentage of Hartmann's procedures.Conclusion DCS is a feasible procedure for patients with generalized peritonitis secondary to perforated diverticulitis, and it appears to be related to a higher rate of bowel reconstruction. Due to the open abdomen, stay in ICU with prolonged mechanical ventilation is required, but these aggressive measures may be needed by most patients undergoing surgery for perforated diverticulitis, whatever the procedure is done.
C1 [Tartaglia, Dario; Camillo, Antonio; Galatioto, Christian; Chiarugi, Massimo] Univ Pisa, New Santa Chiara Hosp, Emergency Surg Unit, Via Paradisa 2, I-56124 Pisa, Italy.
   [Costa, Gianluca; Fransvea, Pietro] Univ Sapienza, St Andrea Teaching Hosp, Emergency Surg Unit, Rome, Italy.
   [Castriconi, Maurizio; Andreano, Mauro; Lanza, Michele] Osped Cardarelli, Emergency Surg Unit, Naples, Italy.
   [Ruscelli, Paolo; Rimini, Massimiliano] Polytech Univ Marche, Osped Riuniti Teaching Hosp, Emergency Surg Unit, Ancona, Italy.
C3 Santa Chiara Hospital; University of Pisa; Sapienza University Rome;
   Antonio Cardarelli Hospital; Marche Polytechnic University
RP Tartaglia, D (通讯作者)，Univ Pisa, New Santa Chiara Hosp, Emergency Surg Unit, Via Paradisa 2, I-56124 Pisa, Italy.
EM dario261184@gmail.com
RI ruscelli, paolo/AAH-4785-2019; Tartaglia, Dario/AAJ-1735-2020; Fransvea,
   Pietro/AAP-1517-2020; Costa, Gianluca/ABD-7262-2020; Chiarugi,
   Massimo/ABQ-7280-2022; rimini, margherita/ONI-9192-2025
OI ruscelli, paolo/0000-0001-5842-2204; Tartaglia,
   Dario/0000-0003-1615-3370; Fransvea, Pietro/0000-0003-4969-3373; Costa,
   Gianluca/0000-0001-5194-8908; Chiarugi, Massimo/0000-0001-6905-2499; 
CR Björck M, 2016, SCAND J SURG, V105, P5, DOI 10.1177/1457496916631853
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   Seetharam S, 2003, AM J SURG, V186, P154, DOI 10.1016/S0002-9610(03)00172-7
   Singer M, 2016, JAMA-J AM MED ASSOC, V315, P801, DOI 10.1001/jama.2016.0287
   Sohn M, 2018, WORLD J SURG, V42, P3189, DOI 10.1007/s00268-018-4585-y
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NR 26
TC 37
Z9 46
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD APR 16
PY 2019
VL 14
AR 19
DI 10.1186/s13017-019-0238-1
PG 6
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA HT9PJ
UT WOS:000464903400001
PM 31015859
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Qiu, Y
   Li, YF
   Gao, BJ
   Li, J
   Pan, LZ
   Ye, Z
   Lin, Y
   Lin, LS
AF Qiu, Yu
   Li, Yanfen
   Gao, Binju
   Li, Jun
   Pan, Lizhen
   Ye, Zuo
   Lin, Yang
   Lin, LiSong
TI Therapeutic efficacy of vacuum sealing drainage-assisted irrigation in
   patients with severe multiple-space infections in the oral,
   maxillofacial, and cervical regions
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Vacuum sealing drainage (VSD)-Assisted irrigation technique; Oral;
   Maxillofacial; Cervical; Severe multiple-space infections
ID WOUND CONTROL; CLOSURE; MANAGEMENT
AB Objective: We compared the clinical efficacy between the vacuum sealing drainage (VSD)-assisted irrigation technique and traditional abscess incision and drainage technique in the treatment of severe multiple-space infections in the oral, maxillofacial, and cervical regions.
   Methods: Data of 73 patients with severe oral, maxillofacial, and cervical infections, who were admitted to the Oral and Maxillofacial Surgery Department at the First Affiliated Hospital of Fujian Medical University between June 2014 and May 2017, were retrospectively collected. Patients were divided into two groups based on the treatments. The cure duration, incision length, physician workload (frequency of dressing-change), and treatment costs were compared between the two groups.
   Results: Of 73 patients, 38 were treated with the VSD-assisted irrigation technique, and 35 with the traditional technique. All patients were cured following treatment. The cure duration, surgical scar length, and physician workload were smaller for the former group than for the latter group (p < 0.05). There was no difference in the treatment costs between the two groups (p > 0.05).
   Conclusion: VSD-assisted irrigation technique used in the treatment of severe multiple-space infection in the oral and maxillofacial cervical regions shows favorable clinical effects and enables short treatment duration, lesser pain-experience, and high clinical and therapeutic efficacy. (C) 2019 Published by Elsevier Ltd on behalf of European Association for Cranio-Maxillo-Facial Surgery.
C1 [Qiu, Yu; Gao, Binju; Li, Jun; Pan, Lizhen; Ye, Zuo; Lin, Yang; Lin, LiSong] Fujian Med Univ, Affiliated Hosp 1, Dept Oral & Maxillofacial Surg, Fuzhou, Fujian, Peoples R China.
   [Li, Yanfen] Fujian Med Univ, Sch & Hosp Stomatol, Fuzhou, Fujian, Peoples R China.
C3 Fujian Medical University; Fujian Medical University
RP Lin, LS (通讯作者)，Fujian Med Univ, Dept Oral & Maxillofacial Surg, Affiliated Hosp 1, Res Inst Facial Restorat & Reconstruct, Fuzhou, Fujian, Peoples R China.
EM qy97@163.com; liyanfen2003@126.com; 244749728@qq.com;
   1986lijun1234@163.com; lilylilylily1234@163.com; 509871462@qq.com;
   komesly@163.com; drlinls@163.com
FU Fujian Provincial Natural Science Foundation [2016J01452]
FX The study was supported by Fujian Provincial Natural Science Foundation
   (2016J01452).
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NR 12
TC 23
Z9 29
U1 0
U2 16
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD MAY
PY 2019
VL 47
IS 5
BP 837
EP 841
DI 10.1016/j.jcms.2019.01.031
PG 5
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA HU3HC
UT WOS:000465162500018
PM 30808610
DA 2026-07-24
ER
PT J
AU Tewarie, L
   Moza, AK
   Khattab, MA
   Autschbach, R
   Zayat, R
AF Tewarie, Lachmandath
   Moza, Ajay K.
   Khattab, Mohammad Amen
   Autschbach, Ruediger
   Zayat, Rashad
TI Effective Combination of Different Surgical Strategies for Deep Sternal
   Wound Infection and Mediastinitis
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE deep sternal wound infection; mediastinitis; bilateral pectoral major
   muscle flap; omental flap
ID VACUUM-ASSISTED CLOSURE; OMENTAL FLAP; RISK-FACTORS; TRANSPOSITION;
   MANAGEMENT; SURGERY; IMPACT
AB Purpose: Timing and ideal reconstructive approach in deep sternal wound infection (DSWI) and mediastinitis still remain controversially debated. We present our own combined surgical strategy of bilateral pectoralis major muscle flap (BPMMF) or omental flap (OF) transposition.
   Methods: Between July 2010 and July 2016, poststernotomy patients with DSWI and mediastinitis underwent a secondary wound closure with modified BPMMF (Group A, center for disease control class (CDC)-II, n = 21; Group B, CDC-III, n = 20) or with OF (Group C, CDC-III, n = 19) following vacuum-assisted closure (VAC).
   Results: Significant risk factors for mediastinitis (CDC-III) were chronic obstructive pulmonary disease (COPD; p = 0.001), peripheral arterial disease (PAD; p = 0.012), cardiopulmonary bypass (CPB) time (p = 0.027), total operation time (p = 0.039), total intensive care unit (ICU) stay (p = 0.011), and blood transfusion (p = 0.049). Mean antibiotic therapy (18.4 +/- 8.8[B] vs. 36.2 +/- 24.4[C] days, p = 0.026) and length of hospitalization (25.2 +/- 12.1[B] vs 53.8 +/- 18.5 days[C], p = 0.053) were significantly longer in group C. In-hospital death was 3/19 (15.8%) in group C versus 0 in group B (p = 0.026). Frequency of recurrent mediastinitis was equal (p = 0.92); however, complications occurred more often in group C (31.6% vs. 0%, p = 0.031). The mean follow-up time was 111 +/- 62 days.
   Conclusion: In younger (< 70 years) patients without sternal bone necrosis, the BPMMF is superior to the OF technique with relatively low recurrence and mortality risks.
C1 [Tewarie, Lachmandath; Moza, Ajay K.; Khattab, Mohammad Amen; Autschbach, Ruediger; Zayat, Rashad] Univ Hosp RWTH Aachen, Dept Thorac & Cardiovasc Surg, Pauwelsstr 30, D-52074 Aachen, Germany.
C3 RWTH Aachen University; RWTH Aachen University Hospital
RP Zayat, R (通讯作者)，Univ Hosp RWTH Aachen, Dept Thorac & Cardiovasc Surg, Pauwelsstr 30, D-52074 Aachen, Germany.
EM rzayat@ukaachen.de
RI Zayat, Rashad/U-5505-2019; Moza, Ajay/KFR-7226-2024
OI Zayat, Rashad/0000-0003-2243-8743; 
CR Athanassiadi Kalliopi, 2007, Asian Cardiovasc Thorac Ann, V15, P200
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NR 23
TC 21
Z9 22
U1 0
U2 4
PU MEDICAL TRIBUNE INC
PI TOKYO
PA ED COMM ANNALS THORACIC CARDIOVASCULAR SURG, 2-1-30 KUDAN MINAMI,
   CHIYODA-KU, TOKYO, 102-0074, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2019
VL 25
IS 2
BP 102
EP 110
DI 10.5761/atcs.oa.18-00115
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA HU7GP
UT WOS:000465449500005
PM 30404980
OA gold
DA 2026-07-24
ER
PT J
AU Egin, S
AF Egin, Seracettin
TI Management of Leakage into the Abdomen due to the Involvement of Jejunum
   in the Incision Line
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Open abdomen; Vacuum-assisted closure; Intraabdominal sepsis
ID ABDOMINAL SEPSIS
AB Here, we present the management of a patient, developing severe peritonitis due to laceration of the jejunum, involving sutures applied to facial layers after anterior resection for adenocarcinoma of the sigmoid colon. The patient, an 83-year woman, was operated by anterior resection, and relaparotomy was performed because the small bowel contents leaked from the incision. A compulsory stoma on the top of the incision was performed. Bilateral fasciocutaneous advancement flaps were carried out to treat the patient with severe intraabdominal sepsis via vacuum-assisted closure. The patient, with Apache-II score 12, open abdomen Bjorck score 2C, and Mannheim peritonitis index score 28, was monitored in the intensive care unit. Based on our experience, open abdomen management with vacuum-assisted closure might be successful for patients with intraabdominal sepsis because of uncontrollable primer sources. We propose that the technique defined for this patient is an innovative technique for primary source control of open abdomen patients.
C1 [Egin, Seracettin] Univ Hlth Sci, Okmeydani Educ & Res Hosp, Dept Surg, Istanbul, Turkey.
C3 Istanbul Okmeydani Training & Research Hospital; University of Health
   Sciences Turkey
RP Egin, S (通讯作者)，Univ Hlth Sci, Okmeydani Educ & Res Hosp, Dept Surg, Istanbul, Turkey.
EM seracettin_egin@hotmail.com
RI Eğin, Seracettin/GQZ-0908-2022
CR Bleszynski MS, 2016, AM J SURG, V211, P926, DOI 10.1016/j.amjsurg.2016.01.012
   Coccolini F, 2017, WORLD J EMERG SURG, V12, DOI 10.1186/s13017-017-0146-1
   Demetriades D, 2012, INT WOUND J, V9, P17, DOI 10.1111/j.1742-481X.2012.01018.x
   Kaplan M, 2005, WOUNDS, P1
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   Sartelli M, 2014, WORLD J EMERG SURG, V9, DOI 10.1186/1749-7922-9-22
   Vargo D, 2009, AM SURGEON, V75, pS1
NR 8
TC 0
Z9 0
U1 0
U2 1
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD MAY
PY 2019
VL 29
IS 5
BP 476
EP 477
DI 10.29271/jcpsp.2019.05.476
PG 2
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HV7MC
UT WOS:000466164100020
PM 31036123
OA gold
DA 2026-07-24
ER
PT J
AU Jin, L
AF Jin, Lei
TI Observation of the effects of two-stage irrigation therapy, combined
   with pedicled flaps, for treatment of infected tissue defects of the
   ankles and feet
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Irrigation; vacuum sealing drainage; infected tissue; flap
ID RISK-FACTORS; DRAINAGE
AB Objective: The aim of this study was to compare the clinical efficacy of two-stage irrigation combined with pedicled flaps and dressing-debridement-dressing circulation for treatment of infected tissue defects of the ankle and foot. Methods: Clinical data of 86 patients with infected tissue defects of the ankle and foot were analyzed, retrospectively. Results: Differences in ankle circumferences, pre- and post-operative, in group A at the 1st, 3rd, and 5th month were significantly smaller than those in group B (all P<0.001), as were visual analog scale (VAS) scores at the same time points (all P<0.001). Verbal rating scale (VRS) scores in group A at the 1st, 3rd, and 5th month were also lower than those in group B (P=0.001). The number of bacteria in group A was less than group B on the 10th day after the operation, as well as 2 weeks before and 2 weeks after drainage tube removal (all P<0.001). Wound healing rates in group A were significantly higher than those in group B at 12 months after the operation (P<0.001). Average hospitalization times and number of dressing changes in group A were respectively shorter and fewer, compared with group B (P<0.001 and P=0.002, respectively). Conclusion: Two-stage irrigation combined with pedicled flaps could reduce local inflammation, edema, pain, and bacterial colonization, as well as facilitate wound healing, shorten hospitalization times, and reduce the average number of dressing changes.
C1 [Jin, Lei] Shanghai Fengxian Dist Hosp, Dept Orthoped, 6600 Nanfeng Rd, Shanghai 201400, Peoples R China.
RP Jin, L (通讯作者)，Shanghai Fengxian Dist Hosp, Dept Orthoped, 6600 Nanfeng Rd, Shanghai 201400, Peoples R China.
EM jinlei75a@163.com
CR Brogden C, 2018, J SPORT REHABIL, P1
   Chen XJ, 2017, BRAZ J MED BIOL RES, V50, DOI [10.1590/1414-431X20175837, 10.1590/1414-431x20175837]
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NR 28
TC 0
Z9 0
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 4
BP 3975
EP 3981
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HW2DW
UT WOS:000466494200098
DA 2026-07-24
ER
PT J
AU Mehdorn, M
   Niebisch, S
   Scheuermann, U
   Gockel, I
   Jansen-Winkeln, B
AF Mehdorn, Matthias
   Niebisch, Stefan
   Scheuermann, Uwe
   Gockel, Ines
   Jansen-Winkeln, Boris
TI Incisional negative pressure wound therapy does not reduce surgical site
   infections in abdominal midline incisions: a case control study
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE Surgical site infections; negative pressure wound therapy; iNPWT
ID HIGH-RISK; CLOSED INCISIONS; GENERAL-SURGERY; LAPAROTOMY; MANAGEMENT;
   TRIAL
AB Purpose: There is evidence from various surgical specialties that incisional negative pressure wound therapy (iNPWT) might reduce postoperative surgical site infections (SSIs). In visceral and general surgery, there is varying evidence of its efficacy in reducing surgical site infections. Methods: A prospectively registered patient cohort of 43 patients with abdominal wall and visceral surgery received treatment with iNPWT and was compared to a matched retrospective cohort to analyze its effects on SSI occurrence and respective risk factors. Groups were matched by procedure, sex, body mass index and age. We used two different systems of iNPWT: (i) PREVENA(TM) or (ii) self-made epicutaneous iNPWT from common VAC material. Results: We could not find a total reduction in postoperative SSIs by application of iNPWT. But within the iNPWT cohort, patients with self-made iNPWT suffered more often from SSIs compared to the commercial iNPWT subgroup. No patient specific risk factors could be identified to advocate the use of iNPWT. Conclusion: Our data do not support the use of an incisional negative pressure wound therapy on closed wounds in midline laparotomy incisions. Although, differences exist between the commmercial and self-made systems.
C1 [Mehdorn, Matthias; Niebisch, Stefan; Scheuermann, Uwe; Gockel, Ines; Jansen-Winkeln, Boris] Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Liebigstr 20, D-04103 Leipzig, Germany.
C3 Leipzig University
RP Jansen-Winkeln, B (通讯作者)，Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Liebigstr 20, D-04103 Leipzig, Germany.
EM Boris.Jansen-Winkeln@medizin.uni-leipzig.de
RI Jansen-Winkeln, Boris/KPA-5791-2024
OI Jansen-Winkeln, Boris/0000-0002-3996-9391
CR Anderson DJ, 2011, INFECT DIS CLIN N AM, V25, P135, DOI 10.1016/j.idc.2010.11.004
   Blackham AU, 2013, AM J SURG, V205, P647, DOI 10.1016/j.amjsurg.2012.06.007
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   Fry DE, 2008, SURG INFECT, V9, P579, DOI 10.1089/sur.2008.9951
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   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
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   Swanson EW, 2016, PLAST SURG-CHIR PLAS, V24, P113, DOI 10.1177/229255031602400207
   Vargo D, 2012, AM J SURG, V204, P1021, DOI 10.1016/j.amjsurg.2012.10.004
   Webster J, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub3
   Weir G, 2014, INT WOUND J, V11, P10, DOI 10.1111/iwj.12261
   Zaidi A, 2017, COLORECTAL DIS, V19, P283, DOI 10.1111/codi.13458
NR 30
TC 5
Z9 6
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5458
EI 2577-0160
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD JUL 3
PY 2020
VL 120
IS 4
BP 250
EP 256
DI 10.1080/00015458.2019.1599180
EA APR 2019
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA MO1SQ
UT WOS:000466650900001
PM 30975040
DA 2026-07-24
ER
PT J
AU Jiménez, JO
   Barno, PA
   Rubio, DR
   Hernández, JDP
   Pérez, JCG
   Montes, IM
   Velasco, GR
   de Blas, ET
   Trill, JD
AF Ocana Jimenez, Juan
   Abadia Barno, Pedro
   Ramos Rubio, Diego
   Pina Hernandez, Juan Diego
   Garcia Perez, Juan Carlos
   Moreno Montes, Irene
   Rodriguez Velasco, Gloria
   Tobaruela de Blas, Estela
   Die Trill, Javier
TI Role of negative pressure wound therapy in the prevention of surgical
   site infection in colorectal surgery
SO CIRUGIA ESPANOLA
LA Spanish
DT Article
DE Surgical site infection; Negative pressure wound therapy; Mechanical
   bowel preparation; Colorectal surgery
ID VACUUM-ASSISTED CLOSURE; NOSOCOMIAL INFECTIONS; RISK-FACTORS;
   LAPAROTOMY; TRIAL; COMPLICATIONS; METAANALYSIS; DISEASE; SYSTEM; COSTS
AB Background: Surgical site infection (SSI) is one of the most frequent complications in colorectal surgery. It is diagnosed in 10 - 20% of colorectal procedures. Negative Pressure Wound Therapy (NPWT) has shown efficacy in the treatment of chronic and traumatic wounds, wound dehiscence, flaps and grafts. The main objective of this study is to assess NPWT in the prevention of SSI in colorectal surgery. Hospital stay reduction and SSI risk factors are secondary objectives.
   Methods: We present a prospective case-control study including 80 patients after a colorectal diagnosis and surgical procedure (elective and non-elective) in 2017. Forty patients were treated with prevention NPWT for one week. Forty patients were treated according to the standard postoperative surgical wound care protocol.
   Results: No significant differences were found in demographic variables, comorbidities, surgical approach, elective or non-elective surgery, mechanical bowel preparation and surgical procedure. Three patients has SSI in the NPWT group (8%) (95%CI 0 - 17.5). Ten patients presented SSI in the control group (25%) (95%CI 12.5 - 37.5) (p = 0.034); OR 0.7 (95%CI 0.006-0.964). Hospital stay in the NPWT group was 8 days versus 12 days in the non-NPWT group (p = 0.22). In the multivariate analysis, mechanical bowel preparation was found to be the only risk factor for SSI (p = 0.047; OR: 0.8, CI 0.45-0.93).
   Conclusions: NPWT is a useful SSI prevention treatment in colorectal surgery. (C) 2019 AEC. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Ocana Jimenez, Juan; Ramos Rubio, Diego] HU Ramon y Cajal, Cirugia Gen & Digest, Madrid, Spain.
   [Abadia Barno, Pedro; Pina Hernandez, Juan Diego; Garcia Perez, Juan Carlos; Moreno Montes, Irene; Rodriguez Velasco, Gloria; Tobaruela de Blas, Estela; Die Trill, Javier] HU Ramon y Cajal, Unidad Coloproctol, Cirugia Gen & Digest, Madrid, Spain.
RP Jiménez, JO (通讯作者)，HU Ramon y Cajal, Cirugia Gen & Digest, Madrid, Spain.
EM jocajim@gmail.com
RI Ramos, Diego/HSH-4501-2023; JUAN CARLOS, GARCIA PEREZ/U-8344-2017;
   /D-9245-2013
OI Ramos, Diego/0000-0003-0191-1968; die trill, javier/0000-0003-2116-9190;
   Abadía Barnó, Peo/0000-0003-4713-9870; JUAN CARLOS, GARCIA
   PEREZ/0000-0002-0326-7128; 
CR Allegranzi B, 2011, LANCET, V377, P228, DOI 10.1016/S0140-6736(10)61458-4
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NR 37
TC 9
Z9 12
U1 0
U2 8
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD MAY
PY 2019
VL 97
IS 5
BP 268
EP 274
DI 10.1016/j.ciresp.2019.03.001
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HW7EO
UT WOS:000466853000005
PM 30981468
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Chen, F
   Shao, QQ
   Hu, JH
   Zhao, Y
   Wang, YP
   Zhang, JG
   Qiu, GX
AF Chen Feng
   Shao Qianqian
   Hu Jianhua
   Zhao Yu
   Wang Yipeng
   Zhang Jianguo
   Qiu Guixing
TI Treatment experience for full-thickness wound dehiscence with
   cerebrospinal fluid leakage following posterior primary spine surgery
   Three case reports
SO MEDICINE
LA English
DT Article
DE CSF leakage; full-thickness wound dehiscence; posterior primary spine
   surgery
ID MANAGEMENT; OSSIFICATION; DRAINAGE; RISK
AB Rationale: Full-thickness wound dehiscence with cerebrospinal fluid (CSF) leakage following posterior spine surgery is a rare but troublesome complication. In the present study, 3 clinical cases associated with this entity are reported.
   Patient concerns: The first case developed incision effusion 5 days after posterior decompression and internal fixation for lumbar spinal stenosis. The second case has the same diagnosis and treatment with the first case. She developed intraoperative CSF leak and incision effusion 7 days after the surgery. The third case developed incision effusion 6 days after posterior single door laminoplasty for cervical spondylosis.
   Diagnosis: All cases developed CSF leak, incision effusion and finally full-thickness wound dehiscence on the postoperative period.
   Interventions: Bed rest, drainage, vacuum sealing drainage (VSD), and reoperations were applied in all of the patients. Trapezius flap transfer was applied to the third case. One lumbar patient developed deep infection and meningitis; thus, the internal fixation and bone graft were removed.
   Outcomes: All of the patients received wound healing finally and were followed up for > 6 months. No incision complications reoccurred, and preoperative symptoms significantly relieved.
   Lessons: Several techniques can be adopted to minimize the incidence of complications and proper surgical repair is the most important. Lumbar cistern drainage and VSD are recommended. Some other available options of management will also help.
C1 Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthoped, Beijing, Peoples R China.
   Chinese Acad Med Sci, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College
RP Hu, JH (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthoped, Beijing 100730, Peoples R China.
EM pumch_hujianhua@163.com
RI ZHAO, YU/GZL-3154-2022
OI ZHAO, YU/0000-0001-9025-2014
FU China postdoctoral science foundation [2017M610813]
FX General financial grant from the China postdoctoral science foundation
   (2017M610813).
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   2008, J BONE JOINT SURG AM, V90, P1101
NR 16
TC 9
Z9 11
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR
PY 2019
VL 98
IS 15
AR e15126
DI 10.1097/MD.0000000000015126
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HX3YM
UT WOS:000467331500036
PM 30985675
OA Green Published, gold
DA 2026-07-24
ER
PT J
AU Collins, J
AF Collins, Jessica
TI Surgical intervention and customised dressings in an extremity wound
   caused by necrotising fasciitis: a case study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE injuries; limb function; necrotising fasciitis; negative pressure wound
   therapy; skin grafting; wounds
AB Necrotising fasciitis can result in extensive loss of soft tissue and limb function. Therefore, surgical intervention requires a balance between extensive tissue removal and saving the limb. A 56-year-old male presented with necrotising fasciitis of the upper extremity. Debridement resulted in a full-thickness wound of the forearm and upper arm, an exposed olecranon and two proximally-based skin flaps. Reconstruction required multiple debridements to optimise the wound for skin grafting and to obtain flap adherence to underlying tissues of the upper arm. Conventional dressings over the flaps proved unsuccessful. Therefore, a customised versatile dressing to address each area of the wound was developed. Negative pressure wound therapy (NPWT) was applied over the exposed muscle (no exposed bone or tendon) of the lower arm and anterior upper arm; a hydropolymer foam dressing covered the elbow region. Closed incision negative pressure wound therapy (ciNPT) was applied over the incision on the posterior upper arm. Ultimately, complete wound closure was achieved, with normal/near-normal range of motion for all joints of the affected limb. There was complete take of skin grafts on the wrist, lower arm and anterior upper arm. ciNPT was effective in holding the incision together and promoting healing of the posterior upper arm, and the hydropolymer foam dressing aided with healing and coverage of the elbow region. In this case, healing of a large, complex upper extremity wound and restored limb function were achieved following use of a combination of surgical techniques and customisation of wound therapy modalities.
C1 [Collins, Jessica] OasisMD Lifestyle Healthcare, Plast & Reconstruct Surg, San Diego, CA 92126 USA.
RP Collins, J (通讯作者)，OasisMD Lifestyle Healthcare, Plast & Reconstruct Surg, San Diego, CA 92126 USA.
EM jessicacollinsmd@gmail.com
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   2008, AM SURG, V74, P809
NR 21
TC 1
Z9 1
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2019
VL 28
IS 5
SU 5
BP S21
EP S27
DI 10.12968/jowc.2019.28.Sup5.S21
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HX5FS
UT WOS:000467426900004
PM 31067168
DA 2026-07-24
ER
PT J
AU Wang, T
   Li, X
   Fan, LH
   Chen, B
   Liu, JJ
   Tao, Y
   Wang, XJ
AF Wang, Tao
   Li, Xu
   Fan, Longhua
   Chen, Bin
   Liu, Jianjun
   Tao, Yue
   Wang, Xiaojun
TI Negative pressure wound therapy promoted wound healing by suppressing
   inflammation via down-regulating MAPK-JNK signaling pathway in diabetic
   foot patients
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Negative pressure wound therapy; JNK; Diabetic patients; Inflammation
ID NITRIC-OXIDE; TNF-ALPHA; MULTICENTER; MECHANISMS; ULCERS
AB Aims: Negative pressure wound therapy displayed significant clinical benefits in the healing of diabetic foot wounds. In the present study, we investigated the mechanism of regulation of MAPK-JNK (Mitogen-activated protein kinase-c-Jun N-terminal kinase) signaling pathway by negative pressure wound therapy on these wounds.
   Methods: Twenty-six type 2 diabetes patients with foot ulceration were randomly assigned to the two groups, thirteen treated with negative pressure wound therapy and the others treated with traditional debridement therapy. Skin samples were harvested and histologically and immunohistochemical analyzed in both groups. Immunofluorescence stain, Enzyme-linked immunosorbent assay and Western blotting were performed for inducible nitric oxide synthase, inter leukin-6, tumor necrosis factor-alpha, P-c-Jun N-terminal kinase and c-Jun N-terminal kinase. Real time-polymerase chain reaction was performed to evaluate expression of c-Jun N-terminal kinase, extracellular signal regulated kinase1/2 and p38.
   Results: Negative pressure wound therapy could effectively alleviate inflammatory reaction and reduce inter leukin-6 and inducible nitric oxide synthase production after 7 days treatment. The level of tumor necrosis factor-alpha, inter leukin-6 and P-c-Jun N-terminal kinase were significantly decreased. However, there was no statistical difference in messenger ribonucleic acid expression of p38, extracellular signal regulated kinase1 and 2.
   Conclusions: Negative pressure wound therapy possibly suppress the wound inflammation by inhibiting inter leukin-6, tumor necrosis factor-alpha and inducible nitric oxide synthase in diabetic foot patients. This effect is maybe mediated at least in part by suppression of Mitogen-activated protein kinase-c-Jun N-terminal kinase signaling pathway. (C) 2019 Elsevier B.V. All rights reserved.
C1 [Wang, Tao; Li, Xu; Fan, Longhua; Liu, Jianjun; Tao, Yue; Wang, Xiaojun] Fudan Univ, Inst Vasc Surg, QingPu Branch, Zhongshan Hosp,Dept Vasc Surg, Shanghai, Peoples R China.
   [Chen, Bin] Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, Inst Vasc Surg, Shanghai 200032, Peoples R China.
C3 Fudan University; Fudan University
RP Fan, LH (通讯作者)，1158 Pk East, Shanghai 201700, Peoples R China.
EM fanlonghua@163.com
RI Chen, Bin/JVZ-3375-2024; Liu, Jianjun/AAK-4989-2020
FU Shanghai Science and Technology Commission Basic Research Surface Item
   [17ZR1405600]; Health and Family Planning Commission of Qingpu District
   [W2018-18]
FX Thank you very much for your reminding. This study received funding of
   Shanghai Science and Technology Commission Basic Research Surface Item
   (17ZR1405600) and Health and Family Planning Commission of Qingpu
   District (W2018-18).
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NR 29
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U1 0
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD APR
PY 2019
VL 150
BP 81
EP 89
DI 10.1016/j.diabres.2019.02.024
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HX8XB
UT WOS:000467689500010
PM 30825563
DA 2026-07-24
ER
PT J
AU Castro-Núñez, J
AF Castro-Nunez, Jaime
TI Distraction Sugosteogenesis: Its Biologic Bases and Therapeutic
   Principles
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Active negative pressure; decompression; marsupialization;
   odontogenesis; odontogenic cysts
ID VACUUM-ASSISTED CLOSURE; KERATOCYSTIC ODONTOGENIC-TUMORS; RETRACTED
   ARTICLE. SEE; MARROW STROMAL CELLS; TERM-FOLLOW-UP; CYSTIC LESIONS;
   DENTIGEROUS CYSTS; MECHANICAL STRAIN; NEGATIVE-PRESSURE; BONE-RESORPTION
AB Purpose: Recently, the terms sugosteogenesis and distraction sugosteogenesis have been introduced to the scientific literature. While the former describes a biologic phenomenon, the latter refers to the clinical technique which relies on the accelerated normal bone healing process that takes place at the osseous walls surrounding a cystic cavity when active negative pressure is applied. The purpose of this study is to provide the biologic bases and the therapeutic principles of this emerging technique. Employing well-stablished biologic principles, clinical evidence from analogous techniques, emerging experimental data, and circumstantial evidence, this study presents the possible mechanism of action of the evacuator for odontogenic cysts (Evocyst), a closed, vacuumlike drain system intended to treat cystic conditions using negative pressure.
   Methods: A review of the literature was done. Keywords for the Medline search were: marsupialization, decompression, odontogenic cysts, effects of negative pressure on bone, and negative pressure wound therapy. In addition, relevant publications from the reference list of the retrieved studies were considered. The matches were evaluated for relevance and analyzed accordingly. Clinical reports used to illustrate the concept of distraction sugosteogenesis were performed following the Declaration of Helsinki on medical protocol and ethics.
   Results: Currently, the standard of care to manage odontogenic cystic lesions includes marsupialization, enucleation and curettage, decompression, and surgical resection. However, there is a need for an alternative option in which the entity could be treated while promoting bone formation. With large odontogenic cystic conditions treated in a short period of time, distraction sugosteogenesis appears to be a choice.
   Conclusion: The application of negative pressure to osseous cells produces a stretching that creates mechanical cues that trigger signaling pathways, promotes fluid flow, and enhances angiogenesis. All of them, combined, may explain sugosteogenesis. The clinical application of such parameters may explain the good clinical results obtained with the Evocyst.
C1 [Castro-Nunez, Jaime] Inst Univ Colegios Colombia, Bogota, Colombia.
   [Castro-Nunez, Jaime] Univ Kentucky, Dept Maxillofacial Surg, Lexington, KY USA.
C3 University of Kentucky
RP Castro-Núñez, J (通讯作者)，Inst Univ Colegios Colombia, Res Dept, Autopista Norte Km 20 Via Chia, Bogota, Colombia.
EM jacastron@hotmail.com
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NR 113
TC 11
Z9 13
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD NOV
PY 2018
VL 29
IS 8
BP 2088
EP 2095
DI 10.1097/SCS.0000000000004892
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HX9DS
UT WOS:000467707800051
PM 30334913
DA 2026-07-24
ER
PT J
AU Zhai, Z
   Yu, L
   Ren, TJ
   Jin, XL
   Yang, XN
   Qi, ZL
AF Zhai, Zhen
   Yu, Lu
   Ren, TianJian
   Jin, Xiaolei
   Yang, Xiaonan
   Qi, Zuoliang
TI Use of Vacuum-Assisted Wound Closure and Tissue Expansion in Revision
   Cranioplasty for a Large-Sized Composite Defect in a Child
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Cranioplasty; pediatrics; revision surgery; tissue expansion; vacuum
   assisted closure
ID RECONSTRUCTION; THERAPY; SCALP
AB Cranioplasty is generally defined as the procedure to reconstruct cranial bone defect arising from congenital or acquired process. As a surgical remedy, it can restore the function of original anatomical structure and produce a satisfactory cosmetic outcome. Although with available options for treating pediatric cranioplasty, large format ( ie, >25 cm(2)) cranioplasty of the aborted one with a composite defect is still a challenging procedure for plastic surgeons. The authors herein present a case of child who suffered failed cranioplasty with polyetheretherketone caused by postoperative infection, leading to skin ulcer and exposure of the polyetheretherketone. The treatments of the patient are performed sequentially. After thorough debridement of the wound, vacuum-assisted wound closure and autologous split-thickness skins are successively used to cover the defect following finally adopted strategy of tissue expansion of the scalp with a 3-dimensional-printed epoxide acrylate maleic composite material to repair the large-sized cranial defect.
C1 [Zhai, Zhen; Yu, Lu; Jin, Xiaolei; Yang, Xiaonan; Qi, Zuoliang] Chinese Acad Med Sci, Plast Surg Hosp, Dept 16, Beijing 100144, Peoples R China.
   [Zhai, Zhen; Yu, Lu; Jin, Xiaolei; Yang, Xiaonan; Qi, Zuoliang] Peking Union Med Coll, Beijing 100144, Peoples R China.
   [Ren, TianJian] Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol Surg, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Plastic Surgery Hospital - CAMS; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Peking Union Medical College; Capital
   Medical University
RP Yang, XN; Qi, ZL (通讯作者)，Chinese Acad Med Sci, Plast Surg Hosp, Dept 16, Beijing 100144, Peoples R China.; Yang, XN; Qi, ZL (通讯作者)，Peking Union Med Coll, Beijing 100144, Peoples R China.
EM yxnan@aliyun.com; public_qi@163.com
RI Yang, Xiaonan/AAL-5154-2020
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 18
TC 3
Z9 4
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD MAY
PY 2019
VL 30
IS 3
BP 838
EP 840
DI 10.1097/SCS.0000000000005181
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HX9JR
UT WOS:000467724100091
PM 30845080
DA 2026-07-24
ER
PT J
AU Caputo, GG
   Marchetti, A
   Governa, M
   Dalla Pozza, E
AF Caputo, Glenda G.
   Marchetti, Alberto
   Governa, Maurizio
   Dalla Pozza, Edoardo
TI A Novel Inexpensive Technique to Seal Negative Pressure Wound Therapy on
   External Fixation Devices
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE external fixation; NPWT; open fracture; colostomy paste; soft tissue
   defect; vacuum therapy; sealing
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTION
AB Negative pressure wound therapy, a tool widely applied to treat lower limb traumas, is useful in reconstructive procedures. However, obtaining an airtight vacuum seal when using a negative pressure dressing around an external fixation device can be complicated and time-consuming. The plastic drape seldom adheres to screws, pins, or wires and, as such, the vacuum seal is jeopardized. In surgical departments, colostomy paste is widely used, readily available, and applied where pins and wires make contact with the plastic drape. It is a fast, practical, and inexpensive method of preventing air leakage. In conclusion, to obtain an airtight seal between the skin and an external fixation device, colostomy paste may be used to ensure an optimal tight seal, even for complex and extended wounds, for 35 days without complications or the requirement for additional dressing changes. Furthermore, it is inexpensive, readily available, simple to use, and quick to apply.
C1 [Caputo, Glenda G.; Marchetti, Alberto; Governa, Maurizio; Dalla Pozza, Edoardo] Azienda Osped Univ Integrata, Dept Plast & Reconstruct Surg, Piazzale Stefani 1, I-37126 Verona, Italy.
C3 University of Verona; Azienda Ospedaliera Universitaria Integrata Verona
RP Dalla Pozza, E (通讯作者)，Azienda Osped Univ Integrata, Dept Plast & Reconstruct Surg, Piazzale Stefani 1, I-37126 Verona, Italy.
EM Edoardo.dallapozza@gmail.com
RI Dalla Pozza, Edoardo/LQK-1101-2024; CAPUTO, Glenda Giorgia/AAT-6653-2020
OI Dalla Pozza, Edoardo/0000-0003-0232-436X; CAPUTO, Glenda
   Giorgia/0000-0002-1930-4317; Marchetti, Alberto/0000-0001-8581-3614
CR Bulla A, 2014, J ORTHOP TRAUMA, V28, pE176, DOI 10.1097/BOT.0000000000000013
   Cigna E, 2013, INT WOUND J, V10, P534, DOI 10.1111/j.1742-481X.2012.01011.x
   Gerszberg KS, 2009, ORTHOPEDICS, V32, P829, DOI 10.3928/01477447-20090922-16
   GODINA M, 1986, PLAST RECONSTR SURG, V78, P285, DOI 10.1097/00006534-198609000-00001
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
   Hendricks N, 2014, OSTOMY WOUND MANAG, V60, P40
   Karadsheh Murad, 2017, Wounds, V29, pE106
   Karadsheh MJ, 2015, WOUNDS, V27, P244
   Lemmon JA, 2008, PLAST RECONSTR SURG, V121, p234E, DOI 10.1097/01.prs.0000305394.80769.8b
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   Raju A, 2014, J RECONSTR MICROSURG, V30, P427, DOI 10.1055/s-0034-1371510
NR 11
TC 5
Z9 6
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD JAN
PY 2019
VL 33
IS 1
BP E24
EP E26
DI 10.1097/BOT.0000000000001281
PG 3
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA HY0JW
UT WOS:000467798900005
PM 30086045
DA 2026-07-24
ER
PT J
AU Nuutila, K
   Yang, L
   Broomhead, M
   Proppe, K
   Eriksson, E
AF Nuutila, Kristo
   Yang, Lu
   Broomhead, Michael
   Proppe, Karl
   Eriksson, Elof
TI PWD: Treatment Platform for Both Prolonged Field Care and Definitive
   Treatment of Burn-Injured Warfighters
SO MILITARY MEDICINE
LA English
DT Article
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; COMBAT EXPLOSIONS;
   MANAGEMENT; GAUZE
AB Introduction: Burns are a very frequent injury type in the battlefield, comprising 5-20% of combat casualties in the recent conflicts. Almost 80% of the burns occur to the face, in part because the face is often not protected. Immediate treatment is critical in the first hours after severe burn injury in order to prevent infection and wound progression. Immediate treatment in the battlefield can be a serious challenge especially if the injury occurs in a remote area with limited transport options. Therefore, novel treatment modalities for prolonged field care when transport to the definitive care is delayed are needed. The purpose of this study was to utilize the platform wound device (PWD) with negative pressure capabilities for the immediate and definitive treatment of porcine full-thickness head burns. Materials and Methods: Full-thickness burn wounds were created on foreheads of seven Yorkshire pigs. Burns were created on day 0, immediately enclosed with the PWD and treated topically with minocycline and lidocaine. On day 3, the burns were surgically debrided. Subsequently, new PWDs were placed on the wounds and continuous negative pressure wound therapy was initiated with either -50 mmHg or -80 mmHg. On day 7, the animals were euthanized and wounds were harvested for analyses. Control wounds were treated with silver sulfadiazine cream. Results: The PWD treatment with negative pressure significantly reduced erythema and edema in the injured tissue and promoted granulation tissue and neocollagen formation by day 7 in comparison to control wounds. In addition, the PWD with both topical minocycline and negative pressure (-80 mmHg or -50 mmHg) reduced bacterial counts in the wounds similar to the current standard of care. Conclusion: This study demonstrates that the PWD is an effective platform for delivery of antibiotics and negative pressure wound therapy for the treatment of full-thickness burns. Therefore, the PWD may be utilized for both prolonged field care and definitive treatment of burn-and blast-injured warfighters.
C1 [Nuutila, Kristo; Yang, Lu; Broomhead, Michael; Proppe, Karl; Eriksson, Elof] Appl Tissue Technol LLC, Hingham, MA 02043 USA.
RP Nuutila, K (通讯作者)，Appl Tissue Technol LLC, Hingham, MA 02043 USA.
FU Small Innovation Research (SBIR) program of the US Department of Defense
   (DoD) [W81XWH-14-C-0015]
FX This material is based upon work supported by the Small Innovation
   Research (SBIR) program of the US Department of Defense (DoD) under
   contract No W81XWH-14-C-0015, phase II effort.
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NR 26
TC 11
Z9 12
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY-JUN
PY 2019
VL 184
IS 5-6
BP E373
EP E380
DI 10.1093/milmed/usy242
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HY5SU
UT WOS:000468188900037
PM 30252082
DA 2026-07-24
ER
PT J
AU Gonzalez, KW
   Chandler, NM
AF Gonzalez, Katherine W.
   Chandler, Nicole M.
TI Ruptured omphalocele: Diagnosis and management
SO SEMINARS IN PEDIATRIC SURGERY
LA English
DT Article
DE Omphalocele; Rupture; Giant; Surgery
ID ABDOMINAL-WALL RECONSTRUCTION; GIANT OMPHALOCELES; GASTROSCHISIS;
   OUTCOMES; THERAPY; INFANTS; MATRIX
AB Omphalocele is an abdominal wall defect which can be classified as small, giant, or ruptured. Ruptured omphaloceles require prompt diagnosis and management to prevent associated morbidity and mortality and represent a challenging surgical condition. This review serves to define the etiology, diagnosis, initial resuscitation, and surgical therapy employed in the treatment of ruptured omphalocele. Resuscitation should focus on maintaining hydration and normothermia. Broad spectrum antibiotics should be initiated. Similar to giant omphaloceles, procedural intervention includes primary closure, silo, synthetic and biologic mesh, negative pressure wound therapy, and topical agents. Despite advances in neonatal care, the prognosis remains guarded and mortality is high. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Gonzalez, Katherine W.; Chandler, Nicole M.] Johns Hopkins All Childrens Hosp, Dept Surg, 501 6th Ave S, St Petersburg, FL 33701 USA.
C3 Johns Hopkins University; Johns Hopkins Medicine
RP Chandler, NM (通讯作者)，Johns Hopkins All Childrens Hosp, Dept Surg, 501 6th Ave S, St Petersburg, FL 33701 USA.
EM nicole.chandler@jhmi.edu
OI Gonzalez, Katherine/0000-0002-5400-5291
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   Ionescu S, 2014, CHIRURGIA-BUCHAREST, V109, P7
   Kelly KB, 2013, SURG CLIN N AM, V93, P1255, DOI 10.1016/j.suc.2013.06.016
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   Roux N, 2018, J PEDIAT SURG
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   Zmora O, 2017, AM J SURG, V214, P479, DOI 10.1016/j.amjsurg.2017.01.004
NR 23
TC 25
Z9 39
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1055-8586
EI 1532-9453
J9 SEMIN PEDIATR SURG
JI Semin. Pediatr. Surg.
PD APR
PY 2019
VL 28
IS 2
BP 101
EP 105
DI 10.1053/j.sempedsurg.2019.04.009
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA HY8HI
UT WOS:000468377600006
PM 31072456
DA 2026-07-24
ER
PT J
AU Schiltz, D
   Wenzel, C
   Brix, E
   Prantl, L
   Taeger, CD
AF Schiltz, Daniel
   Wenzel, Carina
   Brix, Eva
   Prantl, Lukas
   Taeger, Christian D.
TI Salvage of both feet after complete resection of large carcinomas and
   local infection using a new negative pressure wound dressing in
   combination with intermittent instillation therapy
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Negative pressure therapy; Instillation; VAC-Therapy; Cleanse-choice;
   Wound conditioning; VAC; VERAFLO
ID VACUUM-ASSISTED CLOSURE; VAC(R) THERAPY
C1 [Schiltz, Daniel; Wenzel, Carina; Brix, Eva; Prantl, Lukas; Taeger, Christian D.] Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Taeger, CD (通讯作者)，Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
EM christian.taeger@ukr.de
RI prantl, Lukas/AAM-1848-2021; Schiltz, Daniel/HJP-4834-2023
OI prantl, Lukas/0000-0003-2454-2499; Schiltz, Daniel/0000-0003-1096-9336
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NR 20
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD MAY
PY 2019
VL 28
IS 2
BP 120
EP 123
DI 10.1016/j.jtv.2019.01.002
PG 4
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA HZ2XD
UT WOS:000468711200011
PM 30660464
DA 2026-07-24
ER
PT J
AU Beidas, OE
   Garwe, T
   Wicks, RF
   Jalla, A
   Bryant, C
   Sarwar, Z
   Albrecht, RM
AF Beidas, Omar E.
   Garwe, Tabitha
   Wicks, Ryan F.
   Jalla, Aditi
   Bryant, Cressilee
   Sarwar, Zoona
   Albrecht, Roxie M.
TI Equivalent outcomes with once versus thrice weekly dressing changes in
   midline laparotomy wounds treated with negative pressure wound therapy
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; COMPLICATIONS; RISK
AB Background: While negative pressure wound therapy (NPWT) has been used for decades, there is a paucity of data regarding the appropriate length of time between dressing changes.
   Methods: This was a prospective, randomized control trial examining time to wound closure in open midline laparotomy wounds treated with NPWT. The control group received the standard thrice weekly sponge changes (thrice) and the treatment group received once weekly sponge changes (once).
   Results: 44 patients met study criteria over a 3-year period. There was no difference in NPWT duration between the two groups (37.1 vs 34.7 days, p = 0.7324), even after adjusting for potential confounders (p = 0.8091). No differences were found in initial wound size or reduction. The wound complication profile was similar for both groups.
   Conclusion: There is no difference in time to wound closure or complications with NPWT dressing changes once a week compared to the standard three times a week. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Beidas, Omar E.] Univ Oklahoma, Hlth Sci Ctr, Dept Surg, Div Plast Surg, 800 Stanton L Young Blvd, Oklahoma City, OK 73104 USA.
   [Garwe, Tabitha; Wicks, Ryan F.; Jalla, Aditi; Bryant, Cressilee; Sarwar, Zoona; Albrecht, Roxie M.] Univ Oklahoma, Hlth Sci Ctr, Dept Surg, 800 Stanton L Young Blvd, Oklahoma City, OK 73104 USA.
   [Garwe, Tabitha] Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, 800 Stanton L Young Blvd, Oklahoma City, OK 73104 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; University of Oklahoma System; University of Oklahoma
   Health Sciences Center
RP Albrecht, RM (通讯作者)，Univ Oklahoma, Hlth Sci Ctr, Med Director Trauma, Dept Surg,Surg, 800 Stanton L Young Blvd,Suite 9000, Oklahoma City, OK 73104 USA.
EM Roxie-Albrecht@ouhsc.edu
RI Beidas, Omar/NCV-7763-2025
CR Amri R, 2014, AM J SURG, V207, P17, DOI 10.1016/j.amjsurg.2013.05.016
   [Anonymous], MED ED INSTR US
   [Anonymous], 2017, GLOB DAT BOD MASS IN
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   Schintler MV, 2012, DIABETES-METAB RES, V28, P72, DOI 10.1002/dmrr.2243
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NR 33
TC 0
Z9 1
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD JUN
PY 2019
VL 217
IS 6
BP 1065
EP 1071
DI 10.1016/j.amjsurg.2018.10.015
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HZ3II
UT WOS:000468741300016
PM 30342697
DA 2026-07-24
ER
PT J
AU Clark, JM
   Rychlik, S
   Harris, J
   Seikaly, H
   Biron, VL
   O'Connell, DA
AF Clark, Jessica M.
   Rychlik, Shannon
   Harris, Jeffrey
   Seikaly, Hadi
   Biron, Vincent L.
   O'Connell, Daniel A.
TI Donor site morbidity following radial forearm free flap reconstruction
   with split thickness skin grafts using negative pressure wound therapy
SO JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
LA English
DT Article
DE Radial forearm free flap; Split thickness skin graft; Negative pressure
   wound therapy; Wrist; Hand; Patient-reported outcomes
ID OUTCOMES
AB BackgroundDonor site complications secondary to radial forearm free flap (RFFF) reconstruction can limit recovery. Optimizing hand and wrist function in the post-operative period may allow more efficient self-care and return to activities of daily living. Negative pressure wound dressings (NPD) may increase blood flow and perfusion as compared to static pressure dressings (SPD) designed to minimize shear forces during the healing period. This study aims to compare subjective and objective hand and wrist functional outcomes following RFFF reconstruction with split thickness skin grafts (STSG) in patients treated with NPD and SPD.MethodsAdult patients undergoing RFFF with STSG were identified preoperatively and randomized to receive NPD or SPD following their RFFF reconstruction. NPD involved a single-use, portable device capable of applying 80mmHg of negative pressure to the forearm donor site. SPD involved a volar splint. Dressings were left in place for seven days with subjective and objective function assessed at seven days, one month and three months postoperatively. The primary outcome was self-reported hand function as measured with the function subscale of the Michigan Hand Questionnaire (MHQ). Secondary outcomes included hand and wrist strength, range of motion, sensation, scar aesthetics, and skin graft complications.ResultsTwenty-four patients undergoing RFFF were randomized to NPD or SPD. Patients treated with NPD had improved MHQ self-reported functional scores as compared to those treated with SPD at seven days postoperatively (P=0.016). Flexion at seven days was improved in NPD group (P=0.031); however, all other strength and range of motion outcomes were similar between groups. There were no differences in rates of graft complications, scar aesthetics, or sensation.ConclusionsIn the immediate post-operative period, NPD was associated with improved patient-reported hand and wrist function. Wound care to optimize hand and wrist function could allow for improved patient outcomes in the immediate postoperative period.
C1 [Clark, Jessica M.; Rychlik, Shannon; Harris, Jeffrey; Seikaly, Hadi; Biron, Vincent L.; O'Connell, Daniel A.] Univ Alberta, Div Otolaryngol Head & Neck Surg, Dept Surg, 8440-112 St,1E4 Walter Mackenzie Ctr, Edmonton, AB T6G 2B7, Canada.
   [Harris, Jeffrey; Seikaly, Hadi; Biron, Vincent L.; O'Connell, Daniel A.] Alberta Head & Neck Ctr Oncol & Reconstruct, Edmonton, AB, Canada.
C3 University of Alberta
RP O'Connell, DA (通讯作者)，Univ Alberta, Div Otolaryngol Head & Neck Surg, Dept Surg, 8440-112 St,1E4 Walter Mackenzie Ctr, Edmonton, AB T6G 2B7, Canada.; O'Connell, DA (通讯作者)，Alberta Head & Neck Ctr Oncol & Reconstruct, Edmonton, AB, Canada.
EM jmclark@ualberta.ca; danielo@ualberta.ca
CR Andrews BT, 2006, LARYNGOSCOPE, V116, P1918, DOI 10.1097/01.mlg.0000235935.07261.98
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NR 22
TC 32
Z9 34
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
EI 1916-0216
J9 J OTOLARYNGOL-HEAD N
JI J. Otolaryngol-Head Neck Surg.
PD MAY 21
PY 2019
VL 48
AR 21
DI 10.1186/s40463-019-0344-9
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA HZ4ID
UT WOS:000468809800001
PM 31113481
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kubat, E
   Abaci, M
   Ünal, CS
AF Kubat, Emre
   Abaci, Malik
   Unal, Celal Selcuk
TI Z-plasty as an alternative choice for the treatment of recurrent local
   sternal wound infections
SO GENERAL THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE Z-plasty; Sternal wound infection; Sternotomy; Fasciocutaneous flap
ID VACUUM-ASSISTED CLOSURE; FASCIOCUTANEOUS FLAP; MUSCLE FLAPS;
   RISK-FACTORS; MANAGEMENT; SURGERY; CLASSIFICATION; MEDIASTINITIS
AB ObjectiveSternal wound infections after sternotomy are associated with high morbidity, high mortality, and prolonged hospital stay. The recurrence rate of sternal wound infections after single-stage closure is greater than expected. The aim of the study is to present our results of a consecutive series of Z-plasty for the treatment of recurrent sternal wound infections.MethodsBetween March 2015 and March 2017, a total of 9 patients were referred to our clinic with a recurrent sternal wound infection due to sternotomy with or without osteomyelitis. All patients previously underwent one or more surgical procedures for sternal infection. Negative pressure wound therapy and several debridement methods were performed before reconstruction. Two triangular double-transposition fasciocutaneous flap techniques as Z-plasty under local anesthesia was performed for all of the patients.ResultsThe flaps survived completely without any tissue loss. There were no major postoperative complications. One patient had recurrent infection after the flap procedure and was treated with antibiotic therapy. At 6months of follow-up, all of the patients were able to return to normal activities of daily living with a high patient satisfaction rate.ConclusionsLocal sternal wound reconstruction is an effective, rapid, and simple with Z-plasty associated with low recurrence risk. We believe that Z-plasty can be used for recurrent local sternal wound infections as an alternative treatment option for selected patients without mechanical dehiscence.
C1 [Kubat, Emre] Gulhane Training & Res Hosp, Dept Cardiovasc Surg, Gen Dr Tevfik Saglam Cd 1, TR-06010 Ankara, Turkey.
   [Abaci, Malik] Karabuk Training & Res Hosp, Dept Plast Reconstruct & Aesthet Surg, Karabuk, Turkey.
   [Unal, Celal Selcuk] Karabuk Training & Res Hosp, Dept Cardiovasc Surg, Karabuk, Turkey.
C3 Gulhane Training & Research Hospital
RP Kubat, E (通讯作者)，Gulhane Training & Res Hosp, Dept Cardiovasc Surg, Gen Dr Tevfik Saglam Cd 1, TR-06010 Ankara, Turkey.
EM ekubat@gmail.com
RI Abaci, Malik/A-2140-2019; Kubat, Emre/AAQ-3227-2021
OI Abaci, Malik/0000-0001-5145-9629; 
CR Aasi SZ, 2010, DERMAT RES PRACT, V2010, DOI 10.1155/2010/982623
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NR 26
TC 2
Z9 3
U1 0
U2 3
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1863-6705
EI 1863-6713
J9 GEN THORAC CARDIOVAS
JI Gen. Thorac. Cardiovasc. Surg.
PD JUN
PY 2019
VL 67
IS 6
BP 518
EP 523
DI 10.1007/s11748-018-1052-5
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA HZ4VQ
UT WOS:000468849900004
PM 30569256
DA 2026-07-24
ER
PT J
AU Tantu, MM
   Man, GM
   Paunescu, A
   Plesa, CF
   Nicolae, C
   Rogozea, LM
   Bisoc, A
   Mostafa, MF
   Nemes, RM
   Diaconu, M
AF Tantu, Monica Marilena
   Man, George Mihail
   Paunescu, Alina
   Plesa, Cristina Florentina
   Nicolae, Camelia
   Rogozea, Liliana Marcela
   Bisoc, Alina
   Mostafa, Marwa F.
   Nemes, Roxana Maria
   Diaconu, Magdalena
TI Advantages of Negative Pressure Therapy in Local Diabetic Foot Treatment
SO REVISTA DE CHIMIE
LA English
DT Article
DE diabetic foot; negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; ULCERS; MULTICENTER; PREVALENCE;
   AMPUTATION; ROMANIA; COST
AB Diabetic foot is a current public health problem and a late consequence of diabetes. Morbidity and mortality are significant, seriously affecting the patient's quality of life. Treatment of the diabetic foot is a long-lasting, highly resource-consumption process. Using negative pressure therapy leads to shorter hospitalization periods, better functional outcomes, significantly contributes to decreasing the number of amputations and improving patient's quality of life. 49 year-old patient is hospitalized with necrotizing at right foot and shank, neglected type II diabetes. It is performed amputation of atypical necessity, right leg, transtarsal, open stump. After successive debridements, negative pressure therapy is installed for a period of 24 days. This favors the formation of the granular bed, the remission of the infection, allowing grafting. The graft is partially integrated and plantar reconstruction is performed with sural reversal flap. The local and functional results are satisfactory, with the flap viability and the possibility of moving with support on the right leg, preventing the amputation of the shank. Negative pressure therapy has a multitude of advantages, it is preferable to conventional therapies, and it can have higher costs, but accelerates healing and improves the quality of life of the patient.
C1 [Tantu, Monica Marilena; Man, George Mihail; Paunescu, Alina] Univ Pitesti, Fac Sci Phys Educ & Informat, Med Assistance & Phys Therapy Dept, 1 Targu Din Vale Str, Pitesti 110040, Romania.
   [Plesa, Cristina Florentina; Nemes, Roxana Maria] Titu Maiorescu Univ Bucharest, Fac Med, 22 Dambovnicului Str, Bucharest, Romania.
   [Nicolae, Camelia] Carol Davila Univ Med & Pharm, 8 Eroii Sanitari Blvd, Bucharest 050474, Romania.
   [Rogozea, Liliana Marcela; Bisoc, Alina] Transilvania Univ Brasov, Fac Med, 29 Eroilor Blvd, Brasov 500036, Romania.
   [Mostafa, Marwa F.] Mansoura Univ, Fac Nursing, North Delta Sect, Mansoura 35516, Egypt.
   [Diaconu, Magdalena] Univ Med & Pharm Craiova, 2 Petru Rares Str, Craiova 200349, Romania.
C3 National University of Science & Technology POLITEHNICA Bucharest;
   University of Pitesti; Carol Davila University of Medicine & Pharmacy;
   Titu Maiorescu University; Carol Davila University of Medicine &
   Pharmacy; Transylvania University of Brasov; Egyptian Knowledge Bank
   (EKB); Mansoura University; University of Medicine & Pharmacy of Craiova
RP Bisoc, A (通讯作者)，Transilvania Univ Brasov, Fac Med, 29 Eroilor Blvd, Brasov 500036, Romania.
EM alina_bisoc@yahoo.com
RI Bisoc, Alina/HKM-4923-2023; Nemes, Roxana/AAD-6110-2019; Rogozea,
   Liliana/U-2809-2017; PAUNESCU, Alina/AIE-8805-2022; plesa, cristina
   florentina/AAM-6465-2020; Marilena Monica, Tantu/GSD-7373-2022
OI PAUNESCU, Alina/0000-0002-0228-4524; plesa, cristina
   florentina/0000-0003-2048-5431; Marilena Monica,
   Tantu/0000-0002-1038-7953
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   Vaidhya N, 2015, INDIAN J SURG, V77, pS525, DOI 10.1007/s12262-013-0907-3
   Van Acker K, 2001, ACTA CLIN BELG, V56, P21, DOI 10.1179/acb.2001.005
   Veresiu IA, 2015, DIABETES RES CLIN PR, V109, P293, DOI 10.1016/j.diabres.2015.05.020
   Vig S, 2011, J TISSUE VIABILITY, V20, pS1, DOI 10.1016/j.jtv.2011.07.002
NR 38
TC 6
Z9 6
U1 0
U2 10
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD APR
PY 2019
VL 70
IS 4
BP 1307
EP 1310
PG 4
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA IA2JK
UT WOS:000469387200040
DA 2026-07-24
ER
PT J
AU Wang, YY
   Yu, DJ
   Zhao, TL
   Dai, H
   Li, Y
   Bian, HH
   Chen, WB
   Zhang, YS
   Pu, WY
   Feng, JC
   Hu, WT
   Liu, YL
AF Wang, You-you
   Yu, Dao-jiang
   Zhao, Tian-lan
   Dai, Hong
   Li, Yuan
   Bian, Hua-hui
   Chen, Wei-bo
   Zhang, Yu-song
   Pu, Wang-yang
   Feng, Jun-chao
   Hu, Wen-tao
   Liu, Yu-long
TI Successful Rescue of the Victim Exposed to a Super High Dose of
   Iridium-192 during the Nanjing Radiological Accident in 2014
SO RADIATION RESEARCH
LA English
DT Article
ID RADIATION; MANAGEMENT
AB Here we report on the interventions taken to treat a patient exposed to high-dose radiation and provide a protocol for treating such patients in the future. The patient, Mr. Wang, was a 58-year-old male janitor who was accidentally exposed to a (192)Jr source with an activity of 966.4 GBq or 26.1 Ci. The dose estimated to the lower right limb was 4,100 Gy, whereas the whole-body effective dose was 1.51 Gy. The diagnosis was made according to the results of the patient dose estimation and clinical manifestations. Systemic treatment included stimulating bone marrow hematopoietic cells, enhancing immunity, anti-infection and vitamin supplements. The treatment of radiation-induced skin lesions consisted of several debridements, two skin-flap transplantations and application of mesenchymal stem cells (MSCs). Skin-flap transplantations and MSCs play important roles in the recovery of skin wound. A combination of antibiotics and antimycotic was useful in reducing inflammation. The application of vacuum sealing drainage was effective in removing necrotic tissue and bacteria, ameliorating ischemia and hypoxia of wound tissue, providing a fresh wound bed for wound healing and improving skin or flap graft survival rates. The victim survived the accident without amputation, and function of his highly exposed right leg was partially recovered. These results demonstrate the importance of collaboration among members of a multidisciplinary team in the treatment of this patient. (C) 2019 by Radiation Research Society
C1 [Wang, You-you; Dai, Hong; Bian, Hua-hui; Chen, Wei-bo; Zhang, Yu-song; Feng, Jun-chao; Liu, Yu-long] Soochow Univ, Affiliated Hosp 2, Dept Nucl & Radiat Incident Med Emergency Off, Suzhou 215004, Peoples R China.
   [Yu, Dao-jiang; Zhao, Tian-lan] Soochow Univ, Affiliated Hosp 2, Dept Plast Surg, Suzhou 215004, Peoples R China.
   [Li, Yuan; Pu, Wang-yang] Soochow Univ, Affiliated Hosp 2, Dept Oncol & Occupat Med, Suzhou 215004, Peoples R China.
   [Wang, You-you; Dai, Hong; Bian, Hua-hui; Chen, Wei-bo; Zhang, Yu-song; Feng, Jun-chao; Hu, Wen-tao; Liu, Yu-long] Soochow Univ, State Key Lab Radiat Med & Protect, Suzhou 215004, Peoples R China.
   [Wang, You-you; Dai, Hong; Bian, Hua-hui; Chen, Wei-bo; Zhang, Yu-song; Feng, Jun-chao; Hu, Wen-tao; Liu, Yu-long] Soochow Univ, Sch Radiat Med & Protect, Suzhou 215004, Peoples R China.
   [Wang, You-you; Dai, Hong; Bian, Hua-hui; Chen, Wei-bo; Zhang, Yu-song; Feng, Jun-chao; Hu, Wen-tao; Liu, Yu-long] Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215004, Peoples R China.
C3 Soochow University - China; Soochow University - China; Soochow
   University - China; Soochow University - China; Soochow University -
   China
RP Liu, YL (通讯作者)，Soochow Univ, Nucl & Radiat Incident Med Emergency Off, Affiliated Hosp 2, Sanxiang Rd 1055, Suzhou 215004, Peoples R China.
EM yulongliu2002@126.com
RI Chen, Weibo/OQK-7236-2025
CR Bey E, 2010, WOUND REPAIR REGEN, V18, P50, DOI 10.1111/j.1524-475X.2009.00562.x
   Chapel Alain, 2013, World J Stem Cells, V5, P68, DOI 10.4252/wjsc.v5.i3.68
   Eaton EB, 2015, MILITARY MED RES, V2, DOI 10.1186/s40779-014-0027-9
   Gorin NC, 2006, ANN HEMATOL, V85, P671, DOI 10.1007/s00277-006-0153-x
   Iddins CJ, 2014, J AM OSTEOPATH ASSOC, V114, P840, DOI 10.7556/jaoa.2014.170
   Kaigler D, 2003, TISSUE ENG, V9, P95, DOI 10.1089/107632703762687573
   Lataillade JJ, 2007, REGEN MED, V2, P785, DOI 10.2217/17460751.2.5.785
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   Wang Y, 2015, ACTA HAEMATOL-BASEL, V133, P72, DOI 10.1159/000362530
NR 9
TC 5
Z9 11
U1 0
U2 12
PU RADIATION RESEARCH SOC
PI LAWRENCE
PA 810 E TENTH STREET, LAWRENCE, KS 66044 USA
SN 0033-7587
EI 1938-5404
J9 RADIAT RES
JI Radiat. Res.
PD MAY
PY 2019
VL 191
IS 6
BP 527
EP 531
DI 10.1667/RR15274.1
PG 5
WC Biology; Biophysics; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Biophysics; Radiology,
   Nuclear Medicine & Medical Imaging
GA IB1BB
UT WOS:000469997300005
PM 30925136
DA 2026-07-24
ER
PT J
AU Dorneden, A
   Olson, G
   Boyd, N
AF Dorneden, Ashley
   Olson, Garth
   Boyd, Nathan
TI Negative Pressure Wound Therapy (Wound VAC) in the Treatment of Chylous
   Fistula After Neck Dissection
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chylous fistula; chyle leak; neck dissection; postoperative
   complications; wound vac therapy
ID ASSISTED CLOSURE; MANAGEMENT; HEAD; OCTREOTIDE
AB Objectives: Cervical chylous fistula is an uncommon but potentially severe occurrence associated with neck surgery. Methods for treating this problem have inconsistent efficacy and may result in lengthy hospital stays. Negative pressure wound therapy (NPWT) is a highly effective tool in the management of complex wounds. We report 3 cases where NPWT was successfully used to treat chylous fistulas following neck dissection.
   Methods: This is a retrospective chart review of 3 patients who developed chylous fistulas after neck dissection and were successfully treated with NPWT.
   Results: Chylous ouput ceased within 2 to 8 days of proper wound VAC placement. Hospital stays ranged from 6 to 47 days. Patients received altered diets, including TPN for I patient with high-flow output and nil-per-os (NPO) or clear liquids for the others. Patients received octreotide throughout their hospitalization.
   Conclusion: NPWT shows potential as a treatment option for both high-volume and low-volume chylous fistulas following neck dissection.
C1 [Dorneden, Ashley; Olson, Garth; Boyd, Nathan] Univ New Mexico, Dept Surg, Otolaryngol Div, Sch Med, MSC 10 5610,1 Univ New Mexico, Albuquerque, NM 87131 USA.
C3 University of New Mexico
RP Dorneden, A (通讯作者)，Univ New Mexico, Dept Surg, Otolaryngol Div, Sch Med, MSC 10 5610,1 Univ New Mexico, Albuquerque, NM 87131 USA.
EM adorneden@gmail.com
OI Dorneden, Ashley/0000-0002-4039-2032; Olson, Garth/0000-0001-5789-0014
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Campisi CC, 2013, CURR OPIN OTOLARYNGO, V21, P150, DOI 10.1097/MOO.0b013e32835e9d97
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NR 19
TC 11
Z9 14
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-4894
EI 1943-572X
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2019
VL 128
IS 6
BP 569
EP 574
DI 10.1177/0003489419827037
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA IC0QF
UT WOS:000470664200012
PM 30693805
DA 2026-07-24
ER
PT J
AU Jaffe, L
   Wu, SC
AF Jaffe, Leland
   Wu, Stephanie C.
TI Dressings, Topical Therapy, and Negative Pressure Wound Therapy
SO CLINICS IN PODIATRIC MEDICINE AND SURGERY
LA English
DT Article
DE Wounds; Dressings; Topical therapy; Negative pressure wound therapy
ID REGENERATED CELLULOSE/COLLAGEN MATRIX; SILVER DRESSINGS;
   CONTROLLED-TRIAL; GROWTH-FACTORS; FOOT ULCERS; MANAGEMENT; PROTEASES;
   EXPRESSION; GUIDELINES; OUTCOMES
AB The current epidemic of diabetes has created a high demand for skilled wound-care professionals. Wound-care treatment begins with an appreciation of the cause of the ulceration and an adherence to the fundamental pillars of wound care. Also critical in the wound management paradigm is the optimization of the wound environment to facilitate the progression through the stages of healing. This can be accomplished through the use of different topical therapies and wound dressings to generate a favorable condition conducive to healing. This article summarizes the updated literature and best practices related to this topic.
C1 [Jaffe, Leland] Rosalind Franklin Univ, Dr William M Scholl Coll Podiatr Med, Dept Med & Radiol, N Chicago, IL 60064 USA.
   [Wu, Stephanie C.] Rosalind Franklin Univ Med & Sci, Dr William M Scholl Coll Podiatr Med, CLEAR, Ctr Stem Cell & Regenerat Med,Dept Podiatr Surg &, 3333 Green Bay Rd, N Chicago, IL 60064 USA.
C3 Rosalind Franklin University of Medicine & Science; Rosalind Franklin
   University of Medicine & Science
RP Jaffe, L (通讯作者)，Rosalind Franklin Univ, Dr William M Scholl Coll Podiatr Med, Dept Med & Radiol, N Chicago, IL 60064 USA.
EM leland.jaffe@rosalindfranklin.edu
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NR 57
TC 22
Z9 26
U1 0
U2 24
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0891-8422
EI 1558-2302
J9 CLIN PODIATR MED SUR
JI Clin. Podiatr. Med. Surg.
PD JUL
PY 2019
VL 36
IS 3
BP 397
EP +
DI 10.1016/j.cpm.2019.02.005
PG 16
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA IC2QP
UT WOS:000470805100007
PM 31079606
DA 2026-07-24
ER
PT J
AU Pereima, MJL
   Feijó, R
   da Gama, FO
   Boccardi, RD
AF Lopes Pereima, Mauricio Jose
   Feijo, Rodrigo
   da Gama, Fabiana Oenning
   Boccardi, Roberto de Oliveira
TI Treatment of burned children using dermal regeneration template with or
   without negative pressure
SO BURNS
LA English
DT Article
DE Wound healing; Burns; Negative-pressure wound therapy; Child
ID PEDIATRIC BURNS; WOUND THERAPY; RECONSTRUCTION; MANAGEMENT; INTEGRA;
   EPIDEMIOLOGY
AB Objective: Evaluate the results obtained using a Dermal Regeneration Template (DRT) associated or not with the Negative Pressure Wound Therapy (NPWT) for skin cover in paediatric patients who were victims of burns.
   Method: Retrospective study of a cross-sectional study that evaluated the medical records of children submitted to the application of DRT, associated or not with NPWT, for the treatment of burned children admitted to the Joana de Gusmao Children's Hospital (JGCH) in FlorianOpolis, in the period from January 2011 to December 2016, totalling 45 patients.
   Results: The majority of the patients were pubescent (31.8%) males (56.8%), and the main aetiology of the burn was flammable substances (75%). In the group that used only DRT, the average take of DRT was 85% with an average time of maturity of 17.65 days and the mean take rate of the skin graft was 85.2%. In the group that used DRT plus NPWT, the mean DRT take was 99.8%, with a mean maturation time of 16.68 days and the mean of the skin graft take rate was 89.1%.
   Conclusion: NPWT associated with DRT offers a higher rate of success in the treatment of complex wounds caused by burns, promotes increased DRT take rate, reduces DRT maturation time and increases the take rate of the skin graft. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.
C1 [Lopes Pereima, Mauricio Jose] Univ Fed Santa Catarina, Joana de Gusmao Children Hosp, Burn Trauma Ctr, Dept Pediat, Florianopolis, SC, Brazil.
   [Feijo, Rodrigo] Joana de Gusmao Children Hosp, Burn Trauma Ctr, Florianopolis, SC, Brazil.
   [da Gama, Fabiana Oenning; Boccardi, Roberto de Oliveira] Univ Sul Santa Catarina, UNISUL, Florianopolis, SC, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC); Universidade do Sul de
   Santa Catarina
RP Pereima, MJL (通讯作者)，Desembargador Pedro Silva 1952,Apartamento 502-2, BR-88080720 Florianopolis, SC, Brazil.
EM mauricio.pereima@ufsc.br
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NR 33
TC 10
Z9 13
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD AUG
PY 2019
VL 45
IS 5
BP 1075
EP 1080
DI 10.1016/j.burns.2018.08.009
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Dermatology; Surgery
GA IC3JK
UT WOS:000470856100009
PM 31113686
DA 2026-07-24
ER
PT J
AU Jeyapalina, S
   Mitchell, SJ
   Agarwal, J
   Bachus, KN
AF Jeyapalina, Sujee
   Mitchell, Saranne J.
   Agarwal, Jayant
   Bachus, Kent N.
TI Biomimetic coatings and negative pressure wound therapy independently
   limit epithelial downgrowth around percutaneous devices
SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
LA English
DT Article
ID TRANSFEMORAL AMPUTATION; CONNECTIVE-TISSUE; FAILURE MODES; RGD PEPTIDES;
   SKIN BARRIER; ATTACHMENT; IMPLANTS; PROSTHESIS; REHABILITATION;
   INFECTION
AB Biomimetic material coatings and negative pressure wound therapy (NPWT) have been shown independently to limit the epithelial downgrowth rates in percutaneous devices. It was therefore hypothesized that these techniques, in combination, could further limit the clinically observed epithelial downgrowth around these devices. In this study, we evaluated the efficacy of two biomimetic coatings, collagen and hydroxyapatite (HA), to prevent downgrowth when used with continuous NPWT. Using an established single-stage surgical protocol, collagen (n=10) and HA (n=10) coated devices were implanted subdermally on the back of hairless guinea pigs. Five animals from each group were subjected to continuous similar to 90mmHg NPWT. Four weeks post-implantation, animals were sacrificed, and the devices and surrounding tissues were harvested, processed, and downgrowth was computed and compared to historical porous titanium coated controls. Data showed a significant reduction in downgrowth in NPWT treated animals (p0.05) when compared to the untreated porous titanium controls. HA coated devices, without the NPWT treatment, also showed significantly decreased downgrowth compared to the untreated porous titanium controls.
   [GRAPHICS]
   .
C1 [Jeyapalina, Sujee; Mitchell, Saranne J.; Bachus, Kent N.] Dept Vet Affairs Med Ctr, Orthopaed Res Lab, Salt Lake City, UT 84148 USA.
   [Jeyapalina, Sujee; Agarwal, Jayant] Univ Utah, Sch Med, Dept Surg, Div Plast Surg, Salt Lake City, UT 84132 USA.
   [Mitchell, Saranne J.; Bachus, Kent N.] Univ Utah, Orthopaed Ctr, Orthopaed Res Lab, Salt Lake City, UT 84108 USA.
   [Mitchell, Saranne J.; Bachus, Kent N.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
C3 US Department of Veterans Affairs; Utah System of Higher Education;
   University of Utah; Utah System of Higher Education; University of Utah;
   Utah System of Higher Education; University of Utah
RP Jeyapalina, S; Bachus, KN (通讯作者)，Dept Vet Affairs Med Ctr, Orthopaed Res Lab, Salt Lake City, UT 84148 USA.; Jeyapalina, S (通讯作者)，Univ Utah, Sch Med, Dept Surg, Div Plast Surg, Salt Lake City, UT 84132 USA.; Bachus, KN (通讯作者)，Univ Utah, Orthopaed Ctr, Orthopaed Res Lab, Salt Lake City, UT 84108 USA.; Bachus, KN (通讯作者)，Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
EM sujee.jeyapalina@hsc.utah.edu; kent.bachus@hsc.utah.edu
RI Bachus, Kent/KYO-7869-2024
OI Jeyapalina, Sujee/0000-0002-2199-7191; Mitchell, Saranne
   J/0000-0002-6473-7648
FU Department of Defense [W81XWH-11-1-0435]; United States Department of
   Veterans Affairs Rehabilitation Research and Development Service
   [I01RX001217]; Department of Orthopaedics, University of Utah School of
   Medicine, Salt Lake City, Utah
FX This work was supported in part by the Department of Defense
   [#W81XWH-11-1-0435, 2010], by the United States Department of Veterans
   Affairs Rehabilitation Research and Development Service under Merit
   Review Award [#I01RX001217, 2014], and by the Department of
   Orthopaedics, University of Utah School of Medicine, Salt Lake City,
   Utah. The views, opinions, and/or findings presented are those of the
   authors and should not be construed as an official position, policy or
   decision of any of these funding sources unless so designated by other
   documentation. In conducting research using animals, the investigators
   adhered to the Animal Welfare Act Regulations and other Federal statutes
   relating to animals and experiments involving animals and the principles
   set forth in the current version of the Guide for Care and Use of
   Laboratory Animals, National Research Council. The authors wish to
   express their sincere gratitude to Thortex Inc. (Portland, OR) for
   device fabrication and coating support. They also wish to acknowledge
   the Bone and Joint Research Laboratory's Histology Team for their
   technical expertize with the samples embedment process, and Greg
   Stoddard for his help with statistical analysis.
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NR 52
TC 7
Z9 8
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-4530
EI 1573-4838
J9 J MATER SCI-MATER M
JI J. Mater. Sci.-Mater. Med.
PD JUN
PY 2019
VL 30
IS 6
AR 71
DI 10.1007/s10856-019-6272-4
PG 11
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA IC5WN
UT WOS:000471039800001
PM 31183809
DA 2026-07-24
ER
PT J
AU Tran, BNN
   Johnson, AR
   Shen, CY
   Lee, BT
   Lee, ES
AF Bao Ngoc N Tran
   Johnson, Anna Rose
   Shen, Changyu
   Lee, Bernard T.
   Lee, Edward S.
TI Closed-Incision Negative-Pressure Therapy Efficacy in Abdominal Wall
   Reconstruction in High-Risk Patients: A Meta-analysis
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Annual Meeting of the Society-of-Asian-Academic-Surgeons (SAAS)
CY SEP 27-28, 2018
CL Milwaukee, WI
SP Soc Asian Acad Surg
DE Closed-incision negative-pressure therapy; Incisional vac; Complex
   abdominal reconstruction
ID AUTOLOGOUS BREAST RECONSTRUCTION; SURGICAL-SITE INFECTIONS;
   VACUUM-ASSISTED CLOSURE; VENTRAL HERNIA REPAIR; BODY-MASS INDEX; WOUND
   THERAPY; COMPLICATIONS; LAPAROTOMY; OUTCOMES; OBESITY
AB Background: Obesity is a known risk factor for surgical complications. Closed-incision negative-pressure therapy (ciNPT) has been used anecdotally in high-risk patients to prevent wound complications and infection. This meta-analysis aims to evaluate the efficacy of ciNPT in reducing the incidence of wound complications and infection in abdominal wall reconstruction.
   Methods: A literature search using the PubMed/MEDLINE databases (2006-2016) was conducted to identify publications comparing ciNPT to standard incisional care for abdominal wall reconstruction. Outcomes of interest included surgical site infection, wound dehiscence, seroma, hematoma, reoperation, and readmission. Overall rates and associations were pooled. A fixed and random effects model was used upon meta-analysis. Publication bias was assessed using funnel plots.
   Results: A total of 11 studies met inclusion criteria. There were 1723 patients included, 681 in the ciNPT group, and 1042 in the standard incisional care group. The majority of patients were obese, diabetic, and had a recent history of smoking. On meta-analysis, the risk of surgical site infection decreased by 51% (relative risk: 0.51, 95% confidence interval [0.41-0.63]). The risk of wound dehiscence decreased by 51% (relative risk: 0.51, 95% confidence interval [0.34-0.76]). There was no significant decreased risk observed with ciNPT use for the outcomes of seroma, hematoma, reoperation, and readmission.
   Conclusions: The use of ciNPT reduced the incidence of infection and wound dehiscence in patients with varying risk factors undergoing abdominal wall reconstruction. Future prospective randomized clinical trials are still needed to determine the efficacy of ciNPT in plastic surgery. Published by Elsevier Inc.
C1 [Bao Ngoc N Tran; Lee, Edward S.] Rutgers New Jersey Med Sch, Dept Surg, Div Plast & Reconstruct Surg, Newark, NJ USA.
   [Johnson, Anna Rose; Shen, Changyu; Lee, Bernard T.] Harvard Med Sch, Div Plast & Reconstruct Surg, Dept Surg, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Harvard Medical School
RP Lee, ES (通讯作者)，Rutgers New Jersey Med Sch, Div Plast Surg, 140 Bergen St,Suite E1620, Newark, NJ 07103 USA.
EM leee9@njms.rutgers.edu
RI ; Lee, Bernard/K-1106-2016
OI Johnson, Anna Rose/0000-0003-0824-1709; Lee,
   Bernard/0000-0002-5533-3166; Lee, Edward/0000-0003-0487-3493
CR Abbas SM, 2009, ANZ J SURG, V79, P247, DOI 10.1111/j.1445-2197.2009.04854.x
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   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
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NR 45
TC 41
Z9 46
U1 0
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD SEP
PY 2019
VL 241
BP 63
EP 71
DI 10.1016/j.jss.2019.03.033
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA IC7EX
UT WOS:000471137000011
PM 31009887
DA 2026-07-24
ER
PT J
AU Loeck, J
   von Lücken, HJ
   Kehrl, W
   Loske, G
AF Loeck, J.
   von Luecken, H. -J.
   Kehrl, W.
   Loske, G.
TI Endoscopic negative pressure therapy (ENPT) of apost-laryngectomy
   pharyngocutaneous fistula: firstreport of anew treatment method
SO HNO
LA English
DT Article; Proceedings Paper
CT 55th Inner Ear Biology Workshop
CY SEP 06-08, 2018
CL Berlin, GERMANY
DE Respiratory tract fistula; Cutaneous fistula; Wound closure techniques;
   Negative-pressure wound therapy; Drainage
AB In the current first report, it is shown how apost-laryngectomy pharyngocutaneous fistula was successfully closed by endoscopic negative pressure therapy (ENPT; also termed endoscopic vacuum therapy, EVT). The duration of negative pressure treatment was 14days. Up until now, ENPT has been used for treatment of transmural defects in the rectum and esophagus. The new endoscopic method can also be used in the ENT field for closure of pharyngocutaneous fistulas.
C1 [Loeck, J.; von Luecken, H. -J.; Kehrl, W.] Kath Marienkrankenhaus Hamburg gGmbh, Dept Otorhinolaryngol Head & Neck Surg, Hamburg, Germany.
   [Loske, G.] Kath Marienkrankenhaus Hamburg gGmbH, Dept Gen Visceral Thorac & Vasc Surg, Alfredstr 9, D-22087 Hamburg, Germany.
C3 St. Marien Hospital; St. Marien Hospital
RP Loske, G (通讯作者)，Kath Marienkrankenhaus Hamburg gGmbH, Dept Gen Visceral Thorac & Vasc Surg, Alfredstr 9, D-22087 Hamburg, Germany.
EM loske.chir@marienkrankenhaus.org
OI Loeck, Jonathan/0000-0002-7995-9550
CR Boscolo-Rizzo P, 2008, EUR ARCH OTO-RHINO-L, V265, P929, DOI 10.1007/s00405-007-0562-z
   Kuehn F, 2017, SURG ENDOSC, V31, P3449, DOI 10.1007/s00464-016-5404-x
   Loske G, 2019, CHIRURG, V90, pS1, DOI 10.1007/s00104-018-0727-x
   Loske G, 2011, ENDOSCOPY, V43, P540, DOI 10.1055/s-0030-1256345
   Loske G, 2018, ENDOSC INT OPEN, V6, pE865, DOI 10.1055/a-0599-5886
   Reiter M, 2013, AM J OTOLARYNG, V34, P411, DOI 10.1016/j.amjoto.2013.03.001
   Sayles M, 2014, LARYNGOSCOPE, V124, P1150, DOI 10.1002/lary.24448
   Wallstabe I, 2012, ENDOSCOPY, V44, pE49, DOI 10.1055/s-0031-1291525
NR 8
TC 9
Z9 11
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0017-6192
EI 1433-0458
J9 HNO
JI HNO
PD JUN
PY 2019
VL 67
SU 2
BP 77
EP 79
DI 10.1007/s00106-019-0653-3
PG 3
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Otorhinolaryngology
GA ID3WF
UT WOS:000471607100007
PM 31053941
DA 2026-07-24
ER
PT J
AU Jorgensen, MG
   Toyserkani, NM
   Thomsen, JB
   Sorensen, JA
AF Jorgensen, Mads Gustaf
   Toyserkani, Navid Mohamadpour
   Thomsen, Jorn Bo
   Sorensen, Jens Ahm
TI Prophylactic incisional negative pressure wound therapy shows promising
   results in prevention of wound complications following inguinal lymph
   node dissection for Melanoma: A retrospective case-control series
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Lymphadenectomy; Prevention; Incisional negative pressure wound therapy;
   Seroma; Surgical wound infection; Lymphedema
ID METAANALYSIS
AB Background: Inguinal lymphadenectomy (ILND) for melanoma is associated with a number of complications including seroma, surgical site infection (SSI), and lymphedema. Incisional negative pressure wound therapy (iNPWT) has shown promising results in preventing postoperative morbidity across a wide variety of surgical procedures, but these results are yet to be investigated in patients undergoing ILND for melanoma.
   Methods: In this study, we reviewed the data of 55 melanoma patients treated with ILND between January 2015 and January 2017 at Odense University Hospital. Patients were followed up until April 2018 for the occurrence of seroma, SSI, and lymphedema. We used prophylactic iNPWT after ILND in 14 patients and compared their morbidity outcomes with the 41 patients receiving standard postoperative wound care in the same period.
   Results: The iNPWT intervention significantly reduced seroma compared to the control group (28.6% vs. 90.3%, p < 0.001) and had a trending impact on wound infection (42.9% vs. 65.9%, p = 0.13). The effect was not significant for the prevention of lymphedema (35.7% vs. 51.2%, p = 0.33). Because the iNPWT group had relatively fewer incidences of seroma, SSI, and lymphedema, the iNPWT intervention was more cost-effective than conventional wound care (US$911.2 vs. US$ 2542.7, p < 0.05).
   Conclusion: The use of prophylactic iNPWT significantly reduced seroma formation following ILND. These promising results, however, need to be confirmed in a future prospective randomized trial. (C) 2019 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by El-sevier Ltd. All rights reserved.
C1 [Jorgensen, Mads Gustaf; Thomsen, Jorn Bo; Sorensen, Jens Ahm] Odense Univ Hosp, Dept Plast Surg, Sdr Blvd 29, DK-5000 Odense, Denmark.
   [Toyserkani, Navid Mohamadpour] Roskilde Hosp, Dept Plast Surg, Sygehusvej 10, DK-4000 Roskilde, Denmark.
C3 University of Southern Denmark; Odense University Hospital
RP Sorensen, JA (通讯作者)，Odense Univ Hosp, Dept Plast Surg, Sdr Blvd 29, DK-5000 Odense, Denmark.
EM jens.sorensen@rsyd.dk
RI Sørensen, Jens Ahm/D-6279-2014
OI Sørensen, Jens Ahm/0000-0003-4903-0094; Thomsen, Jørn
   Bo/0000-0002-7368-6133; Jørgensen, Mads Gustaf/0000-0002-8755-3446
CR Abbas S, 2011, SURG ONCOL, V20, P88, DOI 10.1016/j.suronc.2009.11.003
   [Anonymous], 2018, DRG TAKSTER 2018
   [Anonymous], 2018, REGION SO DENMARK FA
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
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   Söderman M, 2016, J PLAST SURG HAND SU, V50, P315, DOI 10.3109/2000656X.2016.1173560
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NR 24
TC 17
Z9 20
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JUL
PY 2019
VL 72
IS 7
BP 1178
EP 1183
DI 10.1016/j.bjps.2019.02.013
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ID7XV
UT WOS:000471897100017
PM 30898502
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hu, FX
   Hu, XX
   Yang, XL
   Han, XH
   Xu, YB
   Li, K
   Yan, L
   Chu, HB
AF Hu, Fu Xing
   Hu, Xiao Xuan
   Yang, Xue Lin
   Han, Xing Hai
   Xu, Yong Bo
   Li, Kun
   Yan, Li
   Chu, Hai Bo
TI Treatment of large avulsion injury in perianal, sacral, and perineal
   regions by island flaps or skin graft combined with vacuum assisted
   closure
SO BMC SURGERY
LA English
DT Article
DE Avulsion; Flap; Trauma; Wound closure techniques
ID PRESSURE WOUND THERAPY; RECTAL GUNSHOT WOUNDS; SEALING DRAINAGE;
   MANAGEMENT; TISSUE; DEVICE; TRAUMA
AB BackgroundTraumatic avulsion injuries to the anus, although uncommon, can result in serious complications and even death. Management of anal avulsion injuries remains controversial and challenging. This study aimed to investigate the clinical effects of treating large skin and subcutaneous tissue avulsion injuries in the perianal, sacral, and perineal regions with island flaps or skin graft combined with vacuum assisted closure.MethodsIsland flaps or skin graft combined with vacuum assisted closure, diverting ileostomy, the rectum packed with double-lumen tubes around Vaseline gauze, negative pressure drainage with continuous distal washing, wounds with skin grafting as well as specialized treatment were performed.ResultsThe injuries healed in all patients. Six cases had incomplete perianal avulsion without wound infection. Wound infection was seen in four cases with annular perianal avulsion and was controlled, and the separated prowl lacuna was closed. The survival rate in 10 patients who underwent skin grafting was higher than 90%. No anal stenosis was observed after surgery, and ileostomy closure was performed at 3months (six cases) and 6months (four cases) after surgery, respectively.ConclusionsCovering a wound with an island flap or skin graft combined with vacuum assisted closure is successful in solving technical problems, protects the function of the anus and rapidly seals the wound at the same time.
C1 [Hu, Fu Xing; Yang, Xue Lin; Han, Xing Hai] 89th Hosp PLA, Dept Burn & Plast Surg, Weifang 261021, Peoples R China.
   [Hu, Xiao Xuan] Ningxia Med Univ, Dept Postgrad, Yinchuan 750004, Peoples R China.
   [Xu, Yong Bo; Li, Kun; Yan, Li; Chu, Hai Bo] 89th Hosp PLA, Dept Gen Surg, Weifang 261021, Peoples R China.
C3 Ningxia Medical University
RP Yan, L; Chu, HB (通讯作者)，89th Hosp PLA, Dept Gen Surg, Weifang 261021, Peoples R China.
EM hfx0323@sina.com; yanli2423@163.com; haibochuwf@163.com
FU Weifang City Scientific Development Project of China [2017YX032]
FX This work was supported by the Weifang City Scientific Development
   Project of China (Grant No. 2017YX032). The funding body had no role in
   the study design, data collection and analysis, or preparation of
   manuscript.
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NR 24
TC 9
Z9 12
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD JUN 18
PY 2019
VL 19
AR 65
DI 10.1186/s12893-019-0529-1
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ID9SN
UT WOS:000472027500002
PM 31215452
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lukish, J
   Stewart, D
   Goldstein, S
   Garcia, A
   Pryor, H
   Rhee, D
   Alaish, S
   Colombani, P
AF Lukish, Jeffrey
   Stewart, Dylan
   Goldstein, Seth
   Garcia, Alejandro
   Pryor, Howard
   Rhee, Daniel
   Alaish, Samuel
   Colombani, Paul
TI Microdeformational wound therapy: A novel option to salvage complex
   wounds associated with the Nuss procedure
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Pectus excavatum; Negative pressure wound therapy; PICO vac
ID COMPLICATIONS; INFECTION; SURGERY; DEVICE
AB Background: Complex wounds associated with the Nuss procedure are a resource intensive complication that may lead to significant morbidity with potential removal of the implanted device and abandonment of the repair. We report our management technique of this complication utilizing microdeformational wound therapy (MDWT) that is safe, is efficacious and allows for salvage of the repair.
   Operative technique: We defined a complex wound as a wound that became suppurative and drained in the post-operative period and failed to resolve with a trial of conventional wound management and antibiotics. Upon recognition of a complex wound, we recommend an initial operative wound debridement. This allows wound cultures, wound assessment and precise initiation of MDWT. It is not uncommon to have exposed hardware in the wound early in the course of therapy. Metal allergy must be excluded. The patient is transitioned to oral antibiotics following resolution of the acute process. MDWT is performed until the wounds are completely epithelialized with no clinical signs of drainage or infection. The average length of MDWT in our patients was 39 days. Following complete wound healing the patients are maintained on antibiotics until implant removal.
   Conclusions: The use of microdeformational wound therapy in complex wounds associated with the Nuss procedure is a safe and effective modality. The technique may reduce the likelihood of implant removal with potential recurrent pectus excavatum.
   Type of study: Operative technique. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Lukish, Jeffrey; Pryor, Howard] Childrens Natl Med Ctr, Div Pediat Surg, Washington, DC 20010 USA.
   [Lukish, Jeffrey; Pryor, Howard] Uniformed Serv Univ Hlth Sci, Div Pediat Surg, Bethesda, MD 20814 USA.
   [Stewart, Dylan; Goldstein, Seth; Garcia, Alejandro; Pryor, Howard; Rhee, Daniel; Alaish, Samuel; Colombani, Paul] Johns Hopkins Univ, Div Pediat Surg, Baltimore, MD USA.
   [Colombani, Paul] Johns Hopkins All Childrens Hosp St, Div Pediat Surg, St Petersburg, FL USA.
C3 Children's National Health System; Uniformed Services University of the
   Health Sciences - USA; Johns Hopkins University; Johns Hopkins
   University; Johns Hopkins Medicine
RP Lukish, J (通讯作者)，Childrens Natl Med Ctr, 111 Michigan Ave NW, Washington, DC 20010 USA.
EM jlukish@childrensnational.org
OI Alaish, Samuel/0000-0002-8021-3609; Goldstein, Seth/0000-0001-7806-4109;
   Pryor, Howard/0000-0001-8475-5619
CR AAP Section on Surgery; AAP Committee on Bioethics; AAP American Pediatric Surgical Association New Technology Committee, 2017, PEDIATRICS, V139
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NR 20
TC 1
Z9 1
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD JUL
PY 2019
VL 54
IS 7
BP 1500
EP 1504
DI 10.1016/j.jpedsurg.2019.03.006
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA IE6RD
UT WOS:000472502500041
PM 30967247
DA 2026-07-24
ER
PT J
AU Zeng, FJ
   Chen, C
   Chen, XY
   Zhang, L
   Liu, MH
AF Zeng, Fanjie
   Chen, Cong
   Chen, Xiangyu
   Zhang, Lei
   Liu, Minghua
TI Small Incisions Combined with Negative-Pressure Wound Therapy for
   Treatment of Protobothrops Mucrosquamatus Bite Envenomation: A
   New Treatment Strategy
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Bite Envenomation; Negative-Pressure Wound Therapy; Systemic
   Inflammatory Response Syndrome
ID LOCAL TISSUE-DAMAGE; RATTLESNAKE BITES; BOTHROPS; SNAKEBITE; ENDOCAN;
   ALPHA
AB Background: The aim of this study was to assess the effects of a new treatment strategy for envenomation that consists of multiple small incisions and negative-pressure wound therapy (NPWT) on injured limb swelling and systemic inflammatory reaction.
   Material/Methods: This was a prospective randomized controlled trial on snakebite envenomation. The enrolled patients were randomly divided into 2 groups: an observation group and a control group. The traditional comprehensive treatment was administered in both groups, but the observation group also received combined treatment with multiple small incisions and NPWT. Reduction in limb swelling, mean admission duration, complication rate, and changes in the levels of relevant cytokines were recorded and compared between the 2 groups.
   Results: The mean duration of hospital stay was significantly lower in the observation group than in the control group (5.44 +/- 0.89 days vs. 7.71 +/- 1.70 days). The complication rate and IL-6 concentration were significantly lower in the observation group than in the control group.
   Conclusions: Multiple small incisions combined with NPWT proved effective for controlling the release of inflammatory cytokines and accelerating the relief of systemic inflammatory reaction. As a consequence, the complication rate decreased. Therefore, our new treatment strategy is safe and effective.
C1 [Zeng, Fanjie; Chen, Xiangyu; Zhang, Lei; Liu, Minghua] Army Med Univ, Southwest Hosp, Emergency Dept, Chongqing, Peoples R China.
   [Zeng, Fanjie] 31631 Troop Peoples Liberation Army, Souad Hlth Clin 90, Huizhou, Guangdong, Peoples R China.
   [Chen, Cong] 187th Mil Hosp Peoples Liberat Army, Emergency Dept, Haikou, Hainan, Peoples R China.
C3 Army Medical University
RP Liu, MH (通讯作者)，Army Med Univ, Southwest Hosp, Emergency Dept, Chongqing, Peoples R China.
EM cnminghualiu@163.com
FU Chongqing Science and Technology Benefiting Project
   [CSTC2013jcsfC1001-4]; Scientific Research Innovation Fund of AMU
   [SWH2013LC11]
FX This research was funded by the Chongqing Science and Technology
   Benefiting Project (CSTC2013jcsfC1001-4) and Scientific Research
   Innovation Fund of AMU (SWH2013LC11)
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NR 21
TC 14
Z9 19
U1 1
U2 7
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JUN 17
PY 2019
VL 25
BP 4495
EP 4502
DI 10.12659/MSM.913579
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IE7JP
UT WOS:000472550600001
PM 31204383
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Bedi, M
   King, DM
   DeVries, J
   Hackbarth, DA
   Neilson, JC
AF Bedi, Meena
   King, David M.
   DeVries, John
   Hackbarth, Donald A.
   Neilson, John C.
TI Does Vacuum-assisted Closure Reduce the Risk of Wound Complications in
   Patients With Lower Extremity Sarcomas Treated With Preoperative
   Radiation?
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Musculoskeletal-Tumor-Society (MSTS)
CY SEP 27-29, 2017
CL Denver, CO
SP Musculoskeletal Tumor Soc
ID SOFT-TISSUE SARCOMA; SURGICAL SITE INFECTIONS; THERAPY; RADIOTHERAPY;
   IRRADIATION; PARADOX; SURGERY
AB Background Although preoperative radiation followed by wide local excision yields excellent local control in soft tissue sarcomas, the risk of wound complications is reported to be higher compared with the incidence in patients who were administered postoperative radiation therapy. Vacuum (vac)-assisted closure may improve wound healing, but it is unknown whether vac-assisted closure during soft tissue sarcoma resection may reduce the risk of wound complications or impair local disease control.
   Questions/purposes (1) Does the use of a wound vac application at the time of soft tissue sarcoma resection reduce the risk of developing wound complications after lower extremity sarcoma resection? (2) Is vac-assisted closure associated with an increased risk of local relapse?
   Methods From 2000 to 2016, 312 patients with stage I to III soft tissue sarcomas were treated. Of these, 123 were treated with preoperative radiation +/- chemotherapy followed by limb-sparing resection based on tumor location, size, grade, histology, and patient age. There was a minimum followup of 12 months. Radiation was delivered generally based on tumor size, grade, superficial versus deep nature, and proximity to neurovascular structures. Chemotherapy was administered in patients < 70 years old with high-grade tumors and tumors > 5 cm. Patient, demographic, and treatment variables, including incisional vac application and wound outcomes, were retrospectively evaluated. Incisional vac-assisted closure took place at the time of primary resection in 32% (46 of 123) of patients. Vac-assisted closure was considered when there was a concern for risk of external contamination such as instances in which fixation of adhesives would be difficult or regions where there was a high risk of contamination. Vac-assisted closure may have also been used in instances with increased wound tension at closure or with heightened concern for shearing on the wound such as buttock wounds. Ten patients were lost to followup, two in the vac group and eight in the non-vac group. Potential factors associated with wound complications were evaluated using Fisher's exact test for univariate analysis and logistic regression for multivariate analysis. Local recurrence-free survival was evaluated using the Kaplan-Meier estimate.
   Results After taking into consideration factors such as tumor size, location, age, and patient comorbidities, it was shown that patients who underwent vac-assisted closure were less likely to experience wound complications compared with patients who did not undergo vac-assisted closure (odds ratio, 0.129; 95% confidence interval [CI], 0.041-0.398; p = 0.004). The local control incidence in the entire cohort was 98%. With the numbers available, Kaplan-Meier survivorship free from local recurrence did not differ between patients treated with or without the vac (100% [95% CI, 154.09-154.09] versus 96% [95% CI, 152.21-169.16]; p = 0.211), respectively.
   Conclusions Vac-assisted closure at the time of resection of proximal lower extremity soft tissue sarcomas is associated with a lower risk of wound complications, and its use apparently did not compromise local control. We show that the use of vac-assisted closure may be worth considering in surgeons' attempts to reduce the risk of wound complications among patients with soft tissue sarcomas of the proximal lower extremities.
   Level of Evidence Level III, therapeutic study.
C1 [Bedi, Meena] Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA.
   [King, David M.; DeVries, John; Hackbarth, Donald A.; Neilson, John C.] Med Coll Wisconsin, Dept Orthopaed Surg, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA.
   [Bedi, Meena] Med Coll Wisconsin, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin; Medical College of Wisconsin; Medical
   College of Wisconsin
RP Bedi, M (通讯作者)，Med Coll Wisconsin, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
EM mbedi@mcw.edu
RI Neilson, John/HJP-9461-2023
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NR 21
TC 36
Z9 41
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-921X
EI 1528-1132
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD APR
PY 2019
VL 477
IS 4
BP 768
EP 774
DI 10.1097/CORR.0000000000000371
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics; Surgery
GA IE8FI
UT WOS:000472608900020
PM 30811365
DA 2026-07-24
ER
PT J
AU McElroy, EF
AF McElroy, Elizabeth F.
TI Use of negative pressure wound therapy with instillation and a
   reticulated open cell foam dressing with through holes in the acute care
   setting
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE advanced practice nursing; negative pressure wound therapy; wound
   healing
AB Negative pressure wound therapy with instillation and dwell time (NPWTi-d) is an automated system used to deliver, dwell, and remove topical solutions from the wound bed. Recently, a reticulated open cell foam dressing with through holes (ROCF-CC) was developed, which assists with wound cleansing by removing thick exudate and infectious materials. We present our experience using NPWTi-d with ROCF-CC on complex wounds when complete surgical debridement was inappropriate because of medical instability, recurrent non-viable tissue, or palliative treatment plan. For all wounds, NPWTi-d with ROCF-CC was initiated by instilling normal saline, acetic acid, or hypochlorous acid with 2 to 10 minutes of dwell time, followed by 0.5 to 4 hours of negative pressure. Dressings were changed every 2 to 3 days. Fourteen patients with multiple comorbidities were treated for wound types including diabetic foot ulcers, necrotising fasciitis, dehisced wounds, and pressure injuries. Duration of NPWTi-d with ROCF-CC ranged from 1 to 15 days, and at dressing changes, wounds showed improved granulation tissue formation, less malodour, less surrounding erythema, and demarcation of healthy skin from devitalised tissue. Based on these patients, adjunctive use of NPWTi-d with ROCF-CC provided a practical option for improving tissue quality in wounds for patients in whom surgical debridement was not possible or desired.
C1 [McElroy, Elizabeth F.] Reading Hosp, Tower Hlth Syst, Sixth Ave & Spruce St, W Reading, PA 19603 USA.
RP McElroy, EF (通讯作者)，Reading Hosp, Tower Hlth Syst, Sixth Ave & Spruce St, W Reading, PA 19603 USA.
EM elizabeth.mcelroy@towerhealth.org
RI /AAY-9683-2020
CR Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
   Fernández L, 2017, ANTIBIOTICS-BASEL, V6, DOI 10.3390/antibiotics6040027
   Gabriel Allen, 2014, Plast Surg Nurs, V34, P88, DOI 10.1097/PSN.0000000000000033
   Gupta S, 2016, INT WOUND J, V13, P159, DOI 10.1111/iwj.12452
   Halim AS, 2012, INDIAN J PLAST SURG, V45, P193, DOI 10.4103/0970-0358.101277
   Kim PJ, 2018, WOUNDS, pS1
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Kim PJ, 2013, PLAST RECONSTR SURG, V132, P1569, DOI 10.1097/PRS.0b013e3182a80586
   Kim PJ, 2015, Wounds, V27, pS2
   Milne Jeanette, 2015, Br J Nurs, V24 Suppl 20, pS52, DOI [10.12968/bjon.2015.24.sup20.s52, 10.12968/bjon.2015.24.Sup20.S52]
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   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
   Wolcott R D, 2009, J Wound Care, V18, P54
NR 15
TC 14
Z9 19
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2019
VL 16
IS 3
BP 781
EP 787
DI 10.1111/iwj.13097
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IF2PL
UT WOS:000472920000024
PM 30784210
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU De Donder, L
   Uyttebroek, O
   Van Cleven, S
   Berrevoet, F
AF De Donder, Laura
   Uyttebroek, Ortwin
   Van Cleven, Stijn
   Berrevoet, Frederik
TI A subcutaneous infection mimicking necrotizing fasciitis due to
   Butyricimonas virosa
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE Butyricimonas; anaerobes; necrotizing fasciitis; negative pressure wound
   therapy; LRINEC
ID SP NOV.; BACTEREMIA
AB Introduction: Butyricimonas virosa is a Gram-negative rod who was first identified in rat faces in 2009. Since then only six human infections have been described in literature of which five bacteremia and one bone abscess. We report a clinical case of a subcutaneous infection mimicking necrotizing fasciitis due to B. virosa. Patient and methods: A 78-year-old man was referred to our hospital because of a wound infection at the surgical site with suspicion of necrotizing fasciitis. Treatment consisted of immediate surgical exploration with obtainment of intra-operative specimens for microbiologic examination, 15 d of negative pressure wound therapy (NPWT) and antibiotic treatment with piperacillin-tazobactam (12 d) plus vancomycin (9 d). Results: Surgical exploration did not show necrotising fasciitis but a subcutaneous infection mimicking necrotising fasciitis. The results of the intra-operative specimens revealed the presence of B.virosa and Finegoldia magna. Cultures taken during the NPWT replacements became negative and the patient was able to leave the hospital after 18 d. Conclusions: Considering there was no necrotizing infection present it may have been possible to safely close the wound sooner. However, it is difficult to differentiate between an actual necrotizing fasciitis and a subcutaneous infection mimicking necrotizing fasciitis. Therefore further studies on effective assessment tools to diagnose necrotizing fasciitis, such as the (modified) laboratory risk indicator for necrotizing fasciitis (LRINEC) score and enhanced computed tomography (CT), could be helpful.
C1 [De Donder, Laura] Univ Ghent, Ghent, Belgium.
   [Uyttebroek, Ortwin; Van Cleven, Stijn; Berrevoet, Frederik] Ghent Univ Hosp, Dept Gen & HPB Surg, Ghent, Belgium.
C3 Ghent University; Ghent University; Ghent University Hospital
RP De Donder, L (通讯作者)，Univ Ghent, Ghent, Belgium.
EM laura.dedonder@ugent.be
RI Berrevoet, Frederik/A-6117-2008
CR Bechar J, 2017, ANN ROY COLL SURG, V99, P341, DOI 10.1308/rcsann.2017.0053
   Boyanova L, 2016, ANAEROBE, V42, P145, DOI 10.1016/j.anaerobe.2016.10.007
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   García-Agudo L, 2018, ANAEROBE, V54, P121, DOI 10.1016/j.anaerobe.2018.08.001
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   Toprak N. Ulger, 2015, New Microbes and New Infections, V4, P7, DOI [10.1016/j.nmni.2014.12.004, 10.1016/j.nmni.2014.12.004]
NR 13
TC 8
Z9 8
U1 1
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5458
EI 2577-0160
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD NOV 1
PY 2020
VL 120
IS 6
BP 425
EP 428
DI 10.1080/00015458.2019.1631612
EA JUN 2019
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OK6XN
UT WOS:000472981000001
PM 31203733
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Zeng, JK
   Sun, XJ
   Sun, ZY
   Guan, J
   Han, C
   Zhao, X
   Zhang, P
   Xie, YZ
   Zhao, J
AF Zeng, Junkai
   Sun, Xiaojiang
   Sun, Zhenyu
   Guan, Jie
   Han, Chen
   Zhao, Xin
   Zhang, Pu
   Xie, Youzhuan
   Zhao, Jie
TI Negative Pressure Wound Therapy Versus Closed Suction Irrigation System
   in the Treatment of Deep Surgical Site Infection After Lumbar Surgery
SO WORLD NEUROSURGERY
LA English
DT Article
DE Closed suction irrigation system; Lumbar; Negative pressure wound
   therapy; Spine; Surgical site infection
ID POSTERIOR SPINAL-FUSION; VACUUM-ASSISTED-CLOSURE; RISK-FACTORS;
   INSTRUMENTATION; MANAGEMENT; RETENTION; IMPACT
AB OBJECTIVE: We compared the efficacy of a closed suction irrigation system (CSIS) and negative pressure wound therapy (NPWT) for deep surgical site infection (SSI) after lumbar surgery with instrumentation.
   METHODS: We included 31 patients (NPWT group, n =16; CSIS group, n = 15) with deep SS's after lumbar surgery with instrumentation from 2007 to 2017. The medical records were reviewed and patient characteristics, laboratory results, infection details, and treatment interventions were recorded. The Japanese Orthopaedic Association score and Oswestry disability index were used to assess pain and functional outcomes preoperatively and 3 and 12 months postoperatively. The cost of SSIs were compared between the NPWT and CSIS groups.
   RESULTS: No significant differences were found in the baseline characteristic data between the NPWT and CSIS groups. Implants were retained in all patients in the CSIS group, but required removal from 2 patients with late infections in the NPWT group. The average hospital stay was 36.8 +/- 10.5 days and 33.4 +/- 18.9 days in the NPWT and CSIS groups, respectively. The cost was greater in the NPWT group than in the CSIS group. Both NPWT and CSIS significantly reduced the Oswestry disability index and improved the Japanese Orthopaedic Association scores, but no significant difference was found between the 2 groups.
   CONCLUSIONS: Our results have shown that both NPWT and CSIS are efficient techniques for the management of deep SSI after lumbar surgery with instrumentation. CSIS was more economical and the NPWT system was portable and easier for postoperative nursing care.
C1 [Zeng, Junkai; Sun, Xiaojiang; Sun, Zhenyu; Guan, Jie; Han, Chen; Zhao, Xin; Zhang, Pu; Xie, Youzhuan; Zhao, Jie] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implants, Sch Med,Dept Orthopaed Surg, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University
RP Xie, YZ (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implants, Sch Med,Dept Orthopaed Surg, Shanghai, Peoples R China.
EM drxie_miss@163.com
RI Sun, Zhenyu/OVY-2476-2025
FU National Key Research and Development Program of China [2018YFC2002303];
   Ninth People's Hospital affiliated to Shanghai Jiao Tong University,
   School of Medicine "Multi-Disciplinary Team" Clinical Research Project
   [201701010]; Shanghai Clinical Medical Centre [2017ZZ01023]; Shanghai
   Municipal Key Clinical Specialty
FX The present study was supported by the National Key Research and
   Development Program of China (grant 2018YFC2002303), Ninth People's
   Hospital affiliated to Shanghai Jiao Tong University, School of Medicine
   "Multi-Disciplinary Team" Clinical Research Project (grant 201701010),
   Shanghai Clinical Medical Centre (grant 2017ZZ01023), and the Shanghai
   Municipal Key Clinical Specialty.
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NR 44
TC 27
Z9 33
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD JUL
PY 2019
VL 127
BP E389
EP E395
DI 10.1016/j.wneu.2019.03.130
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA IF5NH
UT WOS:000473128300048
PM 30905647
DA 2026-07-24
ER
PT J
AU Shah, A
   Sumpio, BJ
   Tsay, C
   Swallow, M
   Dash, B
   Thorn, SL
   Sinusas, AJ
   Koo, A
   Hsia, HC
   Au, A
AF Shah, Ajul
   Sumpio, Brandon J.
   Tsay, Cynthia
   Swallow, Matthew
   Dash, Biraja
   Thorn, Stephanie L.
   Sinusas, Albert J.
   Koo, Andrew
   Hsia, Henry C.
   Au, Alexander
TI Incisional Negative Pressure Wound Therapy Augments Perfusion and
   Improves Wound Healing in a Swine Model Pilot Study
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE perfusion; flap; wound healing; negative pressure wound therapy;
   incision; incisional VAC; VAC; externa VAC
ID VACUUM-ASSISTED CLOSURE; ENDOTHELIAL GROWTH-FACTOR; GRANULATION-TISSUE;
   ANGIOGENESIS; MANAGEMENT; INHIBITOR; SURGERY
AB Background: A commonly used treatment for open wounds, negative pressure wound therapy (NPWT) has recently been used to optimize wound healing in the setting of surgically closed wounds; however, the specific mechanisms of action by which NPWT may benefit patients after surgery remain unknown. Using a swine wound healing model, the current study investigates angiogenesis as a candidate mechanism.
   Methods: Multiple excisional wounds were created on the dorsa of 10 male Yorkshire pigs and closed by primary suture. The closed wounds underwent treatment with either NPWT dressing or control dressings in the absence of negative pressure. Dressings were maintained for 8 days followed by euthanasia of the animal. Scar evaluation of the wounds by photographic analysis was performed, and wounds were analyzed for angiogenesis markers by enzyme-linked immunosorbent assay and immunohistochemistry.
   Results: Scar evaluation scores were observed to be significantly higher for the NPWT-treated sites compared with the control sites (P < 0.05). The enzyme-linked immunosorbent assay results demonstrated increases for vascular endothelial growth factor (VEGF) staining at the incision site treated with NPWT compared with other treatment groups (P < 0.05). In addition, an approximately 3-fold elevation in VEGF expression was observed at the NPWT-treated sites (2.8% vs. 1%, respectively; P < 0.0001).). However, there was no significant difference in immunohistochemistry staining.
   Conclusions: The use of NPWT improves the appearance of wounds and appears to increase VEGF expression after 8 days in the setting of a closed excisional wound model, suggesting that improved angiogenesis is one mechanism by which NPWT optimizes wound healing when applied to closed surgical wound sites.
C1 [Shah, Ajul; Sumpio, Brandon J.; Tsay, Cynthia; Swallow, Matthew; Dash, Biraja; Koo, Andrew; Hsia, Henry C.] Yale Univ, Sch Med, Dept Surg, Sect Plast Surg, New Haven, CT 06510 USA.
   [Thorn, Stephanie L.; Sinusas, Albert J.] Yale Univ, Sch Med, Dept Med, Sect Cardiovasc Med, New Haven, CT 06510 USA.
   [Au, Alexander] Univ Penn, Sch Med, Dept Plast Surg, Philadelphia, PA 19104 USA.
C3 Yale University; Yale University; University of Pennsylvania
RP Hsia, HC (通讯作者)，Yale Univ, Sch Med, Sect Plast Surg, Boardman Bldg 3rd Floor,330 Cedar St, New Haven, CT 06510 USA.
EM henry.hsia@yale.edu
RI Sinusas, Albert/A-7235-2009; Koo, Andrew/LYO-4529-2024; Dash,
   Biraja/B-3966-2018; Hsia, Henry/W-6140-2019; Thorn,
   Stephanie/AAD-6988-2022
OI Thorn, Stephanie/0000-0003-0020-0814
FU Kinetic Concepts Inc.
FX This work was supported by grant funding from Kinetic Concepts Inc. All
   authors have no commercial associations or disclosures that may pose or
   create a conflict of interest with the information presented within this
   article. The authors declare no conflict of interest.
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NR 29
TC 29
Z9 34
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD APR
PY 2019
VL 82
SU 3
BP S222
EP S227
DI 10.1097/SAP.0000000000001842
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IF7QP
UT WOS:000473279100013
PM 30855392
DA 2026-07-24
ER
PT J
AU Kawakita, T
   Iqbal, SN
   Overcash, RT
AF Kawakita, Tetsuya
   Iqbal, Sara N.
   Overcash, Rachael T.
TI Negative pressure wound therapy system in extremely obese women after
   cesarean delivery compared with standard dressing
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Article
DE Cesarean; extreme obesity; negative pressure wound therapy; surgical
   site infection; wound complication
ID SURGICAL SITE INFECTION; RISK-FACTORS; COMPLICATIONS
AB Objective: Data regarding the use of the negative pressure wound therapy (NPWT) system in extremely obese women (body mass index [BMI] >= 50 kg/m(2)) undergoing cesarean delivery are limited. We sought to examine the rate of wound complications in extremely obese women according to postcesarean dressings (NPWT [PICO, Smith & Nephew, St. Peterburg, FL] versus standard dressings). Study design: This was a retrospective cohort study of all extremely obese women (BMI >= 50 kg/m(2)) at 23 weeks' gestation or greater who underwent cesarean delivery at an academic teaching hospital in Washington, DC, between January 2009 and September 2017. During this period, a PICO Single Use NPWT system was used at our institution. Women who missed a postpartum follow-up were excluded. Since 2014, Medstar Washington Hospital Center recommended the use of a PICO Single Use NPWT system for extremely obese women at the time of delivery. However, the ultimate decision to use the NPWT was made by attending physicians, considering the cost of the device and the risk of wound complication. Our primary outcome was a composite of cellulitis, hematoma/seroma, and wound dehiscence. Coarsened exact matching with k-to-k solution was performed using BMI, rupture of membranes, and labor. Results: Of 179 extremely obese women, 73 (40.8%) and 106 (59.2%) received NPWT and standard dressings, respectively; 61 women who received NPWT were matched to 61 women who received standard dressings. The rates of the primary outcome in the unmatched cohort were similar between women who received NPWT and those who received standard dressings (20.6 versus 16.0%; p = .44). The rates of primary outcome remained similar between women who received NPWT and those who received standard dressings after matching (18.0 versus 18.0%; p = 1.00). Conclusion: In extremely obese women undergoing cesarean delivery, prophylactic PICO NPWT was not associated with a decreased risk of the primary outcome compared with standard dressings. A large prospective randomized controlled trial would be useful to answer if NPWT is beneficial for extremely obese women.
C1 [Kawakita, Tetsuya; Iqbal, Sara N.; Overcash, Rachael T.] Medstar Washington Hosp Ctr, Div Maternal Fetal Med, Obstet & Gynecol, 101 Irving St NW,5 B45, Washington, DC 20010 USA.
C3 MedStar Washington Hospital Center
RP Kawakita, T (通讯作者)，Medstar Washington Hosp Ctr, Div Maternal Fetal Med, Obstet & Gynecol, 101 Irving St NW,5 B45, Washington, DC 20010 USA.
EM tetsuya.x.kawakita@gmail.com
RI Kawakita, Tetsuya/H-7559-2019
CR Blackwell M, 2009, STATA J, V9, P524, DOI 10.1177/1536867X0900900402
   Blumenfeld YJ, 2015, AM J PERINAT, V32, P825, DOI 10.1055/s-0034-1543953
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   Yu LL, 2018, AM J OBSTET GYNECOL, V218, P200, DOI 10.1016/j.ajog.2017.09.017
NR 18
TC 6
Z9 8
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD FEB 16
PY 2021
VL 34
IS 4
BP 634
EP 638
DI 10.1080/14767058.2019.1611774
EA MAY 2019
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA PH5RK
UT WOS:000473542800001
PM 31018727
DA 2026-07-24
ER
PT J
AU Hall, KD
   Patterson, JS
AF Hall, Kimberly Dawn
   Patterson, Jessica S.
TI Three Cases Describing Outcomes of Negative-Pressure Wound Therapy With
   Instillation for Complex Wound Healing
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Dehisced abdominal wound; Diabetic foot wound; Enterocutaneous fistula;
   Instillation; Negative-pressure wound therapy; NPWT; NPWTi-d
ID VACUUM-ASSISTED CLOSURE; ENTEROCUTANEOUS FISTULAS; SALINE INSTILLATION;
   MANAGEMENT
AB BACKGROUND: We describe 3 cases where negative-pressure wound therapy with instillation and dwell time (NPWTi-d) was used as an adjunctive therapy for 3 chronic wounds. CASES: Three patients (2 males and 1 female), ranging in age from 28 to 53 years, presented with complex, infected wounds: (1) a diabetic foot ulcer with underlying infection, (2) a dehisced abdominal wound with enterocutaneous fistula, and (3) a large wound of the upper torso and axillary region resulting from soft tissue necrosis. Negative-pressure wound therapy with instillation and dwell time was initiated by instilling normal saline or an antiseptic solution; the solution was left in place for 3 to 10 minutes. Continuous negative pressure was then applied at -125 or -150 mm Hg; cycles were repeated every 1 or 3 hours. Treatment was applied for 5 to 44 days, and dressings were changed every 2 to 3 days. Granulation tissue developed in all 3 wounds; all closed after subsequent skin grafting. CONCLUSIONS: Outcomes of these cases suggest that NPWTi-d may be used as an adjunctive treatment modality for a variety of chronic wounds.
C1 [Hall, Kimberly Dawn; Patterson, Jessica S.] Carilion Clin, Roanoke, VA 24014 USA.
   [Hall, Kimberly Dawn] KCI USA Inc, West San Antonio, TX USA.
RP Hall, KD (通讯作者)，Carilion Clin, Roanoke, VA 24014 USA.
EM kdhall@carilionclinic.org
RI Patterson, Jessica/OQK-5789-2025
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Anghel EL, 2016, INT WOUND J, V13, P19, DOI 10.1111/iwj.12664
   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
   Ciancio F, 2017, AESTHET PLAST SURG, V41, P466, DOI 10.1007/s00266-016-0734-6
   Cro C, 2002, POSTGRAD MED J, V78, P364, DOI 10.1136/pmj.78.920.364
   Daunton C, 2012, WOUND PRACT RES, V20, P174
   Draus JM, 2006, SURGERY, V140, P570, DOI 10.1016/j.surg.2006.07.003
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   Fife CE, 2012, WOUNDS, V24, P10
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   Gabriel Allen, 2014, Eplasty, V14, pe41
   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
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   Lessing MC, 2013, EPLASTY, V13, pe51
   Leung BK, 2010, WOUNDS, V22, P179
   Murphy Patrick S, 2012, Plast Surg Int, V2012, P190436, DOI 10.1155/2012/190436
   Raad W, 2010, INT WOUND J, V7, P81, DOI 10.1111/j.1742-481X.2010.00658.x
   Sen CK, 2009, WOUND REPAIR REGEN, V17, P763, DOI 10.1111/j.1524-475X.2009.00543.x
   Wainstein Daniel Edgardo, 2008, World J Surg, V32, P430
   Wolvos Tom, 2004, Ostomy Wound Manage, V50, P56
   Woodfield JC, 2006, ANZ J SURG, V76, P1085, DOI 10.1111/j.1445-2197.2006.03956.x
NR 29
TC 7
Z9 10
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2019
VL 46
IS 3
BP 251
EP 255
DI 10.1097/WON.0000000000000516
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA IH1LM
UT WOS:000474252300016
PM 31022125
DA 2026-07-24
ER
PT J
AU Guo, K
   Gong, WB
   Zheng, T
   Hong, ZW
   Wu, XW
   Ren, HJ
   Wang, GF
   Gu, GS
   Nthumba, P
   Ren, JA
   Li, JS
AF Guo, Kun
   Gong, Wenbin
   Zheng, Tao
   Hong, Zhiwu
   Wu, Xiuwen
   Ren, Huajian
   Wang, Gefei
   Gu, Guosheng
   Nthumba, Peter
   Ren, Jianan
   Li, Jieshou
TI Clinical parameters and outcomes of necrotizing soft tissue infections
   secondary to gastrointestinal fistulas
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Necrotizing soft tissue infections; Gastrointestinal fistula; Outcome
ID FASCIITIS SECONDARY; MANAGEMENT; SEPSIS; SKIN; GUIDELINES; DIAGNOSIS;
   SURGERY; CARE
AB BackgroundNecrotizing soft tissue infections (NSTIs) is severe surgical infections which can occur following trauma or abdominal surgery. NSTIs secondary to gastrointestinal (GI) fistula is a rare but severe complication.MethodsA retrospective cohort study was performed on all subjects presenting with GI fistulas associated NSTIs were included. Clinical characteristics, microbiological profile, operations performed, and outcomes of patients were analyzed.ResultsBetween 2014 and 2017, 39 patients were finally enrolled. The mean age were 46.9years and male were the dominant. For the etiology of fistula, 25 (64.1%) of the patients was due to trauma. Overall, in-hospital death occurred in 15 (38.5%) patients. Microbiologic findings were obtained from 31 patients and Klebsiella pneumoniae was the most common species (41.0%). Eight patients were treated with an open abdomen; negative pressure wound therapy was used in 33 patients and only 2 patients received hyperbaric oxygen therapy. Younger age and delayed abdominal wall reconstruction repair were more common in trauma than in non-trauma. Non-survivors had higher APACHE II score, less source control<48h and lower platelet count on admission than survivors. Multiple organ dysfunction syndrome, multidrug-resistant organisms and source control failure were the main cause of in-hospital mortality.ConclusionsTrauma is the main cause of GI fistulas associated NSTIs. Sepsis continues to be the most important factor related to mortality. Our data may assist providing enlightenment for quality improvement in these special populations.
C1 [Guo, Kun; Zheng, Tao; Hong, Zhiwu; Wu, Xiuwen; Ren, Huajian; Wang, Gefei; Gu, Guosheng; Ren, Jianan; Li, Jieshou] Nanjing Univ, Dept Gen Surg, Sch Med, Jinling Hosp, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China.
   [Gong, Wenbin] Southeast Univ, Jinling Hosp, Dept Gen Surg, Sch Med, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China.
   [Nthumba, Peter] AIC Kijabe Hosp, Kijabe, Kenya.
C3 Nanjing University; Southeast University - China
RP Ren, JA (通讯作者)，Nanjing Univ, Dept Gen Surg, Sch Med, Jinling Hosp, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China.
EM guokunmedical@126.com; jiananr@gmail.com
RI Wu, Xiuwen/AEO-0814-2022; NTHUMBA, PETER/AEJ-0393-2022
OI Wu, Xiuwen/0000-0002-3813-3867; 
FU Key Project of Jiangsu Social Development [BE2016752]; Innovation
   Project of Military Medicine [16CXZ007]
FX The work was supported by grants from the Key Project of Jiangsu Social
   Development (BE2016752) and Innovation Project of Military Medicine
   (16CXZ007). The funders had no role in the design of the study and
   collection, analysis, and interpretation of data and in writing the
   manuscript.
CR Al-Khoury G, 2008, J AM COLL SURGEONS, V206, P397, DOI 10.1016/j.jamcollsurg.2007.07.027
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   Bertram P, 2000, LANGENBECK ARCH SURG, V385, P39, DOI 10.1007/s004230050009
   Bonne SL, 2017, INFECT DIS CLIN N AM, V31, P497, DOI 10.1016/j.idc.2017.05.011
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   Chen IC, 2011, CRIT CARE, V15, DOI 10.1186/cc10278
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   Connolly PT, 2008, ANN SURG, V247, P440, DOI 10.1097/SLA.0b013e3181612c99
   de Prost N, 2015, INTENS CARE MED, V41, P1506, DOI 10.1007/s00134-015-3916-9
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   Gunter OL, 2008, SURG INFECT, V9, P443, DOI 10.1089/sur.2007.053
   Hsu WH, 2014, SURG INFECT, V15, P467, DOI 10.1089/sur.2012.008
   Husnoo N, 2016, ANN ROY COLL SURG, V98, pE130, DOI 10.1308/rcsann.2016.0177
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   Moore SA, 2015, SURG INFECT, V16, P813, DOI 10.1089/sur.2015.002
   Mulla ZD, 2007, EPIDEMIOL INFECT, V135, P868, DOI 10.1017/S0950268806007448
   Okoye O, 2013, AM SURGEON, V79, P1081
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   Schecter WP, 2009, J AM COLL SURGEONS, V209, P484, DOI 10.1016/j.jamcollsurg.2009.05.025
   Seternes A, 2017, WORLD J SURG, V41, P152, DOI 10.1007/s00268-016-3694-8
   Seymour CW, 2016, JAMA-J AM MED ASSOC, V315, P762, DOI 10.1001/jama.2016.0288
   Solomkin JS, 2013, CLIN INFECT DIS, V56, P1765, DOI 10.1093/cid/cit128
   Stevens DL, 2014, CLIN INFECT DIS, V59, pE10, DOI [10.1093/cid/ciu296, 10.1093/cid/ciu444]
   Takeda M, 2012, SURG TODAY, V42, P781, DOI 10.1007/s00595-012-0140-x
   Williams Lara J, 2010, Clin Colon Rectal Surg, V23, P209, DOI 10.1055/s-0030-1263062
   Zhao JC, 2017, BMC INFECT DIS, V17, DOI 10.1186/s12879-017-2907-6
NR 36
TC 7
Z9 9
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD JUL 9
PY 2019
VL 19
AR 597
DI 10.1186/s12879-019-4248-0
PG 10
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA IJ2KE
UT WOS:000475730900005
PM 31288746
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ishii, N
   Kiuchi, T
   Uno, T
   Uoya, Y
   Kishi, K
AF Ishii, Naohiro
   Kiuchi, Tomoki
   Uno, Takahiro
   Uoya, Yuichiro
   Kishi, Kazuo
TI Effective Salvage Surgery of a Severely Congested Propeller Perforator
   Flap Using a Postoperative Delay Technique and Negative-Pressure Wound
   Therapy
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE congestion; delay; negative-pressure wound therapy; pressure sore;
   propeller perforator flap
AB Wound edge-based propeller perforator flaps have often been applied to soft tissue reconstruction of sacral pressure sores. Although this flap often causes necrosis due to overtension and twisting of the perforators, salvage surgery using a postoperative delay technique has not been reported thus far. In this article, we present a case in which we successfully reconstructed a sacral pressure sore using a wound edge-based propeller perforator flap. The flap caused severe congestion, which had a concern due to the potential wide-ranging flap loss; it was subsequently salvaged by an emergent delay procedure and negative-pressure wound therapy on day 2 postoperatively.
C1 [Ishii, Naohiro; Kiuchi, Tomoki; Uno, Takahiro; Uoya, Yuichiro] Int Univ Hlth & Welf Hosp, Nasushiobara City, Tochigi, Japan.
   [Kishi, Kazuo] Keio Univ, Tokyo, Japan.
C3 International University of Health & Welfare; Keio University
RP Ishii, N (通讯作者)，Int Univ Hlth & Welf Hosp, Dept Plast & Reconstruct Surg, 537-3 Iguchi, Nasushiobara City, Tochigi 3292763, Japan.
EM ishinao0916@gmail.com
OI Ishii, Naohiro/0000-0001-8838-5344
CR Jakubietz RG, 2011, J RECONSTR MICROSURG, V27, P194, DOI 10.1055/s-0030-1270537
   Kelahmetoglu O, 2017, INT WOUND J, V14, P1183, DOI 10.1111/iwj.12783
   Korambayil Pradeoth M, 2010, Indian J Plast Surg, V43, P151, DOI 10.4103/0970-0358.73427
   Lin CH, 2012, J PLAST SURG HAND SU, V46, P430, DOI 10.3109/2000656X.2012.727823
   Sisti A, 2016, IN VIVO, V30, P351
NR 5
TC 1
Z9 2
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2020
VL 19
IS 1
BP 86
EP 88
AR 1534734619863513
DI 10.1177/1534734619863513
EA JUL 2019
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LA8RW
UT WOS:000476122900001
PM 31304821
DA 2026-07-24
ER
PT J
AU Mu, SC
   Hua, QQ
   Jia, YY
   Chen, MW
   Tang, YZ
   Deng, DT
   He, Y
   Zuo, CL
   Dai, F
   Hu, HL
AF Mu, Shichang
   Hua, Qiaoqiao
   Jia, Yangyang
   Chen, Ming-Wei
   Tang, Yizhong
   Deng, Datong
   He, Yong
   Zuo, Chunlin
   Dai, Fang
   Hu, Honglin
TI Effect of negative-pressure wound therapy on the circulating number of
   peripheral endothelial progenitor cells in diabetic patients with mild
   to moderate degrees of ischaemic foot ulcer
SO VASCULAR
LA English
DT Article
DE Diabetic foot ulcer; endothelial progenitor cell; negative-pressure
   wound therapy; cytokines
ID MOBILIZATION; MANAGEMENT; INFECTION
AB Objective To investigate the effect of negative-pressure wound therapy (NPWT) on the circulating number of endothelial progenitor cells (EPCs) in diabetic patients with mild to moderate degrees of ischemic foot ulcer. Methods We selected 84 diabetic patients who had a foot ulcer with a duration of at least four weeks and who had an ankle-brachial index of 0.5-0.9. Patients were assigned to one two groups according to 2:1 randomization: NPWT group (n = 56) and non-NPWT (patients who did not receive NPWT) group (n = 28). The control group (NC group) was composed of 18 patients who had normal glucose tolerance and lower extremity ulcer without arteriovenous disease. NPWT was performed on the ulcer after debridement for one week for patients in both the NPWT group and the NC group, and the patients in the non-NPWT group received conventional treatment process. The circulating number of EPCs was measured before and after various treatments, and the factors influencing their changes were analysed. Results After NPWT, the circulating number of EPCs significantly increased in both the NPWT group and the NC group ((85.3 +/- 18.1) vs. (34.1 +/- 12.5)/10(6) cells; (119.9 +/- 14.4) vs. (66.1 +/- 10.6)/10(6) cells, both P < 0.05). In contrast, the circulating number of EPCs had no significant change in the non-NPWT group ((45.2 +/- 19.4) vs. (34.7 +/- 16.8)/10(6) cells, P > 0.05). In addition, the circulating levels of vascular endothelial growth factor (VEGF) and the protein expressions of VEGF and stromal cell-derived factor-1 alpha (SDF-1 alpha) in the granulation tissue significantly increased after NPWT in both the NPWT and the NC group, but there was no significant change in the non-NPWT group. Compared with the non-NPWT group, the changes in VEGF and SDF-1 alpha levels in the sera and granulation tissue were all significantly higher in both the NPWT and NC groups (P < 0.05, P < 0.01, respectively). There was no significant difference in changes in the circulating number of EPCs in the peripheral blood and levels of VEGF and SDF-1 alpha in the sera and granulation tissue between the NPWT and NC groups. Correlation analysis showed that the change in the circulating number of EPCs was correlated with the changes of VEGF and SDF-1 alpha levels in the sera and granulation of the NPWT and NC groups (P < 0.05). Conclusion NPWT may increase the circulating number of EPCs in diabetic patients with mild to moderate ischaemic foot ulcer as in non-diabetic controls, which may be attributed to the upregulation of systemic and local VEGF and SDF-1 alpha levels.
C1 [Mu, Shichang; Hua, Qiaoqiao; Jia, Yangyang; Chen, Ming-Wei; Deng, Datong; He, Yong; Zuo, Chunlin; Dai, Fang; Hu, Honglin] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, Jixi Rd 218, Hefei 230032, Anhui, Peoples R China.
   [Chen, Ming-Wei] Acad Tradit Chinese Med, Inst Diabet Prevent & Control, Hefei, Anhui, Peoples R China.
   [Tang, Yizhong] Anhui Med Univ, Affiliated Hosp 1, Dept Burns, Hefei, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Chen, MW (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, Jixi Rd 218, Hefei 230032, Anhui, Peoples R China.; Chen, MW (通讯作者)，Acad Tradit Chinese Med, Inst Diabet Prevent & Control, Hefei, Anhui, Peoples R China.
EM chmw1@163.com
RI Jia, yang/HTN-3694-2023
FU Clinical Medical Special Foundation of Chinese Society [13061050490]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Funding
   for this project was provided by Clinical Medical Special Foundation of
   Chinese Society (13061050490).
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   Tanaka T, 2016, EUR J PLAST SURG, V39, P247, DOI 10.1007/s00238-016-1200-z
   Tecilazich F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083314
   Wang RR, 2015, INT J CLIN EXP MED, V8, P12548
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   Zan T, 2015, CELL BIOCHEM FUNCT, V33, P143, DOI 10.1002/cbf.3091
NR 31
TC 16
Z9 18
U1 0
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD AUG
PY 2019
VL 27
IS 4
BP 381
EP 389
DI 10.1177/1708538119836360
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA IK3ZE
UT WOS:000476526100007
PM 30841790
DA 2026-07-24
ER
PT J
AU Rodrigues, AC
   Saad, KR
   Saad, PF
   Otsuki, DA
   dos Santos, LC
   Rasslan, S
   Montero, EFD
   Utiyama, EM
AF Rodrigues, Adilson Costa
   Saad, Karen Ruggeri
   Saad, Paulo Fernandes
   Otsuki, Denise Aya
   dos Santos, Luana Carla
   Rasslan, Samir
   de Souza Montero, Edna Frasson
   Utiyama, Edivaldo M.
TI Continuous peritoneal lavage with vacuum perito-neostomy: an
   experimental study
SO CLINICS
LA English
DT Article
DE Peritonitis; Open Abdomen; Laparostomy; Peritoneal Lavage;
   Vacuum-Assisted Closure; Abdominal Sepsis
ID INTRAABDOMINAL INFECTION; DORSOVENTRAL LAVAGE; MANAGEMENT; SURGERY;
   SALINE
AB OBJECTIVE: Despite advances in diffuse peritonitis treatment protocols, some cases develop unfavorably. With the advent of vacuum therapy, the use of laparostomy to treat peritonitis has gained traction. Another treatment modality is continuous peritoneal lavage. However, maintaining this technique is difficult and has been associated with controversial results. We propose a new model of continuous peritoneal lavage that takes advantage of the features and benefits of vacuum laparostomy.
   METHOD: Pigs (Landrace and Large White) under general anesthesia were submitted to laparostomy through which a multiperforated tube was placed along each flank and exteriorized in the left and lower right quadrants. A vacuum dressing was applied, and intermittent negative pressure was maintained. Peritoneal dialysis solution (PDS) was then infused through the tubes for 36 hours. The stability of peritoneostomy with intermittent infusion of fluids, the system resistance to obstruction and leakage, water balance, hemodynamic and biochemical parameters were evaluated. Fluid disposition in the abdominal cavity was analyzed through CT.
   RESULTS: Even when negative pressure was not applied, the dressing maintained the integrity of the system, and there were no leaks or blockage of the catheters during the procedure. The aspirated volume by vacuum laparostomy was similar to the infused volume (9073.5 +/- 1496.35 mL versus 10165 +/- 235.73 mL, p=0.25), and there were no major changes in hemodynamic or biochemical analysis. According to CT images, 60 ml/kg PDS was sufficient to occupy all intra-abdominal spaces.
   CONCLUSION: Continuous peritoneal lavage with negative pressure proved to be technically possible and may be an option in the treatment of diffuse peritonitis.
C1 [Rodrigues, Adilson Costa] Univ Sao Paulo, Fac Med, Cirurgia, Hosp Clin HCFMUSP, Sao Paulo, SP, Brazil.
   [Saad, Karen Ruggeri; Saad, Paulo Fernandes] Univ Fed Vale Sao Francisco, Fac Med, Petrolina, PE, Brazil.
   [Otsuki, Denise Aya] Univ Sao Paulo, Fac Med FMUSP, Lab Anestesiol LIM 08, Sao Paulo, SP, Brazil.
   [dos Santos, Luana Carla; Rasslan, Samir; de Souza Montero, Edna Frasson] Univ Sao Paulo, Fac Med FMUSP, Lab Fisiopatol Cirurg LIM 62, Sao Paulo, SP, Brazil.
   [Utiyama, Edivaldo M.] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Clin Cirurg 3, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal do Vale do Sao
   Francisco; Universidade de Sao Paulo; Universidade de Sao Paulo;
   Universidade de Sao Paulo
RP Montero, EFD (通讯作者)，Univ Sao Paulo, Fac Med FMUSP, Lab Fisiopatol Cirurg LIM 62, Sao Paulo, SP, Brazil.
EM edna.montero@gmail.com
RI Otsuki, Denise Aya/J-2849-2014; Utiyama, Edivaldo Massazo/K-5804-2018;
   Montero, Edna/AAJ-1372-2021; Saad, Karen/N-5373-2015
OI Otsuki, Denise Aya/0000-0002-7411-3898; Utiyama, Edivaldo
   Massazo/0000-0002-8453-7184; Montero, Edna/0000-0003-1437-1219; Saad,
   Karen/0000-0002-3904-9026; Rodrigues, Adilson/0000-0003-4990-6826
CR Adkins AL, 2004, AM SURGEON, V70, P137
   Breborowicz A, 2005, PERITON DIALYSIS INT, V25, pS67
   Buijk SE, 2002, INTENS CARE MED, V28, P1024, DOI 10.1007/s00134-002-1383-6
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   van Goor H, 2002, LANGENBECK ARCH SURG, V387, P191, DOI 10.1007/s00423-002-0309-7
NR 19
TC 0
Z9 0
U1 0
U2 2
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PY 2019
VL 74
AR e937
DI 10.6061/clinics/2019/e937
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IK5NW
UT WOS:000476632900001
PM 31291390
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Wee, IJY
   Mak, M
   O'Donnell, G
   Tan, J
   Chong, TT
   Tang, TY
AF Wee, Ian J. Y.
   Mak, Manfred
   O'Donnell, Gavin
   Tan, Jerilyn
   Chong, Tze T.
   Tang, Tjun Y.
TI The smart negative pressure (SNaP) wound care system: A case series from
   Singapore
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE outcome; SNaP; vacuum-assisted closure; wound
ID VACUUM-ASSISTED CLOSURE; LEG ULCERS; THERAPY; MULTICENTER
AB The Smart Negative Pressure (SNaP) wound care system is a novel device that is single-patient use, ultra-portable, and light weight and does not rely on battery or need recharging. A systematic search was performed on major databases to identify relevant articles including case reports, retrospective case series, and randomised controlled trials. Ten studies were identified, showing that the SNaP wound care system is an effective tool in treating small-sized wounds and may serve as an alternative to current electrically powered modalities. Furthermore, the system's small size and convenience leads to greater patient satisfaction and improves quality of life. Finally, we report our initial positive experiences with two cases in our institution. Although the evidence thus far has been encouraging, and patient satisfaction is higher than other wound care systems, further evidence is required to determine its superiority over current systems in terms of wound-healing outcomes.
C1 [Wee, Ian J. Y.] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Mak, Manfred; O'Donnell, Gavin; Tan, Jerilyn] Singapore Gen Hosp, Dept Podiatry, Singapore, Singapore.
   [Chong, Tze T.; Tang, Tjun Y.] Singapore Gen Hosp, Dept Vasc Surg, Level 5,20 Coll Rd, Singapore 169856, Singapore.
C3 National University of Singapore; Singapore General Hospital; Singapore
   General Hospital
RP Tang, TY (通讯作者)，Singapore Gen Hosp, Dept Vasc Surg, Level 5,20 Coll Rd, Singapore 169856, Singapore.
EM tang.tjun.yip@singhealth.com.sg
RI ; Mak, Manfred/LJK-1821-2024
OI Wee, Ian/0000-0001-8778-1943; 
CR Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
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   Awad TBM, 2012, WOUNDS INT, V3, P44
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
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   Fong KD, 2010, WOUNDS, V22, P230
   Fong KD, 2010, PLAST RECONSTR SURG, V125, P1362, DOI 10.1097/PRS.0b013e3181d62b25
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   Lerman B, 2010, PLAST RECONSTR SURG, V126, P1253, DOI 10.1097/PRS.0b013e3181ea4559
   Lerman Bruce, 2010, J Diabetes Sci Technol, V4, P825
   Marston WA, 2015, ADV WOUND CARE, V4, P75, DOI 10.1089/wound.2014.0575
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   Neiderer K, 2012, OSTOMY WOUND MANAG, V58, P44
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NR 17
TC 5
Z9 7
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2019
VL 16
IS 4
BP 891
EP 896
DI 10.1111/iwj.13114
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IK6AN
UT WOS:000476667700003
PM 30900370
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Shine, J
   Efanov, JI
   Paek, L
   Coeugniet, É
   Danino, MA
   Izadpanah, A
AF Shine, Julien
   Efanov, Johnny I.
   Paek, Laurence
   Coeugniet, Edouard
   Danino, Michel A.
   Izadpanah, Ali
TI Negative pressure wound therapy as a definitive treatment for upper
   extremity wound defects: A systematic review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE hand; NPWT; upper extremity; VAC
ID VACUUM-ASSISTED CLOSURE; RADIAL FOREARM FLAP; DONOR-SITE; SKIN-GRAFTS;
   INTEGRA; RECONSTRUCTION; HAND; MECHANISM; COVERAGE; DEVICE
AB Negative pressure wound therapy (NPWT) represents one of the many solutions for complex wounds of the upper extremity. The goal of this study was to investigate the most common indications for definitive treatment of wound defects in the upper extremity with NPWT and to report revision surgery outcomes after its use. A systematic review of the literature was performed. The following keywords and their combinations were used: "upper extremity," "arm," "forearm," "wrist," "hand," "finger" AND "negative-pressure wound therapy," "VAC therapy," "vacuum assisted closure." A total of 45 articles were included, regrouping 404 cases of NPWT in the upper extremity. The forearm was involved in 53% of cases, followed by hand (36%), fingers (10%), and arm (1%). Seventeen different indications were cited, the most common of which were radial forearm flap reconstruction (23%), burn wounds (18%), and compartment syndromes (17%). Of the cases, 90% did not require any subsequent surgical procedure, as opposed to 6% considered partial failures requiring minor revisions and 4% total failures requiring major revisions. Closure of radial forearm flap donor site required the most revision procedures when treated with NPWT. NPWT can be used for several indications pertaining to the reconstruction of the upper extremity. Positive outcomes as a definitive treatment are demonstrated in this systematic review, which reaffirms NPWT as a potent tool for reconstructive endeavours.
C1 [Shine, Julien; Efanov, Johnny I.; Paek, Laurence; Coeugniet, Edouard; Danino, Michel A.; Izadpanah, Ali] CHUM, Plast & Reconstruct Surg Serv, Montreal, PQ, Canada.
C3 Universite de Montreal
RP Efanov, JI (通讯作者)，CHUM, Plast & Reconstruct Surg, 1051 Rue Sanguinet, Montreal, PQ H2X 3E4, Canada.
EM johnny.ionut.efanov@umontreal.ca
RI Efanov, Johnny Ionut/AFT-0368-2022; coeugniet, edouard/AAF-3264-2019;
   danino, alain/E-4103-2012
CR Andrews BT, 2006, LARYNGOSCOPE, V116, P1918, DOI 10.1097/01.mlg.0000235935.07261.98
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NR 30
TC 15
Z9 19
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2019
VL 16
IS 4
BP 960
EP 967
DI 10.1111/iwj.13128
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IK6AN
UT WOS:000476667700013
PM 30950218
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Barbera, F
   Lorenzetti, F
   Marsili, R
   Lisa, A
   Guido, G
   Pantaloni, M
AF Barbera, Federico
   Lorenzetti, Fulvio
   Marsili, Ricccardo
   Lisa, Andrea
   Guido, Gabriele
   Pantaloni, Marcello
TI The Impact of Preoperative Negative-Pressure Wound Therapy on Pectoralis
   Major Muscle Flap Reconstruction for Deep Sternal Wound Infections
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE deep sternal wound infection; muscle flap; negative-pressure wound
   therapy; pectoralis major muscle flap; sternal reconstruction
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; PERISTERNAL
   THORACIC WALL; MEDIAN STERNOTOMY; BLOOD-FLOW; CARDIAC-SURGERY;
   RISK-FACTORS; MANAGEMENT; COMPLICATIONS; IRRIGATION
AB Background Deep sternal wound infection (DSWI) represents a life-threatening complication following open-heart surgery and pectoralis major muscle flap reconstruction has led to a significant reduction in mortality and morbidity. Negative-pressure wound therapy represented a step forward in DSWI treatment, both as a single procedure or as a preparation for reconstructive surgery. In the present study, we report our 13 years' experience with sternal reconstruction in order to evaluate the impact of preoperative vacuum-assisted closure (VAC) therapy on reconstructive outcome. Methods Seventy-three patients diagnosed with DSWI undergoing pectoralis major muscle flap reconstruction were divided into 2 subgroups: preoperative VAC treatment group (n = 37) and no preoperative VAC (NVAC n = 36). We collected patients' DSWI and reconstructive surgery clinical data, and we analyzed surgical outcome in terms of complication rate, reoperation rate, defects closure times, and intraoperative/30-day and 1-year mortality. Results Eighty-three flaps were used, bilateral flaps were used more in the NVAC subgroup (P = 0.005), and operative time was significantly shorter in the VAC subgroup (P < 0.001). Complication rate was 9.6%, with no significant differences between the 2 subgroups (P = 0.723). There was no recurrence of mediastinitis, and all flaps survived. Sternal closure time was significantly lower in the VAC subgroup (P < 0.001). No intraoperative death occurred; 30-day and 1-year mortality were 2.7% and 19.2%, respectively, with no significant difference between the 2 groups (P = 0.596). Conclusions Preoperative VAC therapy makes reconstructive surgery easier and faster, even though it has no impact on complication rate and overall success of the reconstruction. Pectoralis major muscle flap represents a reliable solution even if not associated with preoperative VAC.
C1 [Barbera, Federico; Lorenzetti, Fulvio; Marsili, Ricccardo; Pantaloni, Marcello] Univ Pisa, Santa Chiara Hosp, Plast & Reconstruct Surg Unit, Piazza Martiri delle Liberta 33, I-56127 Pisa, Italy.
   [Barbera, Federico] Scuola Super St Anna Univ & Perfezionamento, Pisa, Italy.
   [Lisa, Andrea; Guido, Gabriele] Univ Milan, Reconstruct & Aesthet Plast Surg Sch, Dept Med Biotechnol & Translat Med BIOMETRA, Plast Surg Unit,Humanitas Res Hosp, Milan, Italy.
C3 University of Pisa; Santa Chiara Hospital; Scuola Superiore Sant'Anna;
   University of Milan
RP Barbera, F (通讯作者)，Univ Pisa, Santa Chiara Hosp, Plast & Reconstruct Surg Unit, Piazza Martiri delle Liberta 33, I-56127 Pisa, Italy.
EM f.barbera90@gmail.com
RI Lisa, Anea/AAN-3564-2020
OI Lisa, Anea/0000-0003-2134-5633
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NR 66
TC 10
Z9 15
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD AUG
PY 2019
VL 83
IS 2
BP 195
EP 200
DI 10.1097/SAP.0000000000001799
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IK6EY
UT WOS:000476679700014
PM 30882416
DA 2026-07-24
ER
PT J
AU Li, JF
   Zhang, H
   Qi, BW
   Pan, ZY
AF Li, Jingfeng
   Zhang, Hao
   Qi, Baiwen
   Pan, Zhenyu
TI Outcomes of Vacuum Sealing Drainage Treatment Combined with Skin Flap
   Transplantation and Antibiotic Bone Cement on Chronic Tibia
   Osteomyelitis: A Case Series Study
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Bone Cements; Drainage; Osteomyelitis; Skin Transplantation
ID RISK-FACTORS; MASQUELET TECHNIQUE; EXTERNAL FIXATION; PERFORATOR FLAP;
   SHAFT FRACTURE; LOWER LEG; RECONSTRUCTION; INFECTION; DEFECTS; RESECTION
AB Background: Chronic osteomyelitis is one of the currently refractory diseases. The aim of this study is to discuss the method and curative effects of vacuum sealing drainage (VSD) treatment combined with skin flap transplantation and antibiotic bone cement for chronic tibia osteomyelitis.
   Material/Methods: For this study, 18 cases of open fracture secondary chronic tibia osteomyelitis were selected. After the granulation tissue of the wound surface became fresh and infection was controlled, the wound surface was repaired with a medial head of gastrocnemius transfer flap or a myofascial and cutaneous island pedicle flap with a collateral vessel nourished by the retrograde sural nerve. VSD combined with focus debridement and antibiotic bone cement filling was conducted. After inflammation was completely regulated, elective bone cement extraction, bone grafting, and internal fixation were performed. Within 2 to 3 years of follow-up post-surgery, the satisfaction and recurrence rates were evaluated. The patients' pre-operative and post-operative recovery of limb functions were compared according to the Enneking scoring system.
   Results: The patients did not suffer from osteomyelitis recurrence, with the exception of 1 case that manifested osteomyelitis recurrence and recovered through surgical treatment within the period of follow-up. The satisfaction and recurrence rates of these study cases post-surgery were 94.4% and 5.6%, respectively. The average functional recovery post-surgery was 81.5% of normal function.
   Conclusions: Vacuum sealing drainage combined with skin flap transplantation and antibiotic bone cement is an effective treatment for chronic tibia osteomyelitis.
C1 [Li, Jingfeng; Zhang, Hao; Qi, Baiwen; Pan, Zhenyu] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan, Hubei, Peoples R China.
C3 Wuhan University
RP Pan, ZY (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan, Hubei, Peoples R China.
EM soloistp@126.com
CR Accadbled F, 2013, ORTHOP TRAUMATOL-SUR, V99, P479, DOI 10.1016/j.otsr.2013.01.008
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NR 31
TC 16
Z9 23
U1 0
U2 22
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JUL 19
PY 2019
VL 25
BP 5343
EP 5349
DI 10.12659/MSM.915921
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IK9LH
UT WOS:000476916100001
PM 31320603
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Wu, ML
   Sun, MY
   Dai, HY
   Xu, JG
   Wang, XW
   Guo, R
   Wang, YC
   Xue, CY
AF Wu, Minliang
   Sun, Mengyan
   Dai, Haiying
   Xu, Jianguo
   Wang, Xinwei
   Guo, Rui
   Wang, Yuchong
   Xue, Chunyu
TI The application of keystone flap combined with vacuum-assisted closure
   in the repair of sacrococcygeal skin defect after tumor resection
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE keystone design perforator island flap; sacrococcygeal region; tumor;
   vacuum-assisted closure; wound repair
ID ISLAND FLAP; BLOOD-FLOW; PERFORATOR; THERAPY
AB ObjectiveWe aimed to explore the efficacy of keystone flap combined with vacuum-assisted closure (VAC) in the repair of sacrococcygeal wounds.
   MethodsThis study is a retrospective review of patients undergoing keystone flap reconstruction between January 2014 and January 2018. A standardized data collection template was used to collect related variables. The detailed process of the reconstructive surgery is carefully described in this study. The postoperative healing process was closely observed.
   ResultsTwelve patients underwent keystone flap repair between January 2014 and January 2018. The average wound size before closure measured 7.831.93x 5.28 +/- 0.91cm. All the patients achieved primary wound healing and the flaps survived during the follow-up period, which ranged from 1 to 24 months. No severe complications and obvious scar appeared, and the patients were satisfied with both appearance and function.
   ConclusionsThe application of keystone flap combined with VAC is a promising way to repair wounds in the sacrococcygeal region with little postoperative complication and similar soft-tissue thickness to the surrounding tissue.
C1 [Wu, Minliang; Sun, Mengyan; Dai, Haiying; Xu, Jianguo; Wang, Xinwei; Guo, Rui; Wang, Yuchong; Xue, Chunyu] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
C3 Naval Medical University
RP Wang, YC; Xue, CY (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM drwangyc@163.com; xcyfun@sina.com
RI ; Wu, Minliang/GPT-4264-2022; xu, jianguo/JZD-9552-2024
OI 王, 宇翀/0000-0001-5094-5553; 
CR [Anonymous], COCHRANE DATABASE SY
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NR 20
TC 6
Z9 7
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD JUN
PY 2019
VL 119
IS 7
BP 974
EP 978
DI 10.1002/jso.25397
PG 5
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA IK9TK
UT WOS:000476938900021
PM 30714165
DA 2026-07-24
ER
PT J
AU Hahn, HM
   Lee, IJ
   Woo, KJ
   Park, BY
AF Hahn, Hyung Min
   Lee, Il Jae
   Woo, Kyong-je
   Park, Bo Young
TI Silver-Impregnated Negative-Pressure Wound Therapy for the Treatment of
   Lower-Extremity Open Wounds: A Prospective Randomized Clinical Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE bacterial load; lower extremity; negative-pressure wound therapy; open
   wounds; silver; wound dressing
ID VACUUM-ASSISTED CLOSURE; EVIDENCE-BASED RECOMMENDATIONS; DRESSINGS;
   STEPS
AB OBJECTIVE To investigate the antibacterial efficacy of silver-impregnated negative-pressure wound therapy (NPWT) in lower-extremity acute traumatic wounds. METHODS Open contaminated wounds caused by high-velocity trauma in the lower extremities were randomly allocated into two groups. The wounds in the control and experimental groups were treated with conventional NPWT (n = 31) and silver-impregnated NPWT (n = 35), respectively. MAIN OUTCOME MEASURES Serial bacterial cultures were obtained from the participants' wounds, polyurethane foam, and suction tubes weekly during the 4-week follow-up to identify bacteria and follow their conversions. MAIN RESULTS Bacterial colonization rates in the silver NPWT group were generally lower than those in the conventional NPWT group, and the difference increased with time. For methicillin-resistant Staphylococcus aureus colonization, wounds treated with silver-impregnated NPWT showed a significant reduction in bacterial load compared with those treated with conventional NPWT. CONCLUSIONS Silver-impregnated NPWT effectively decreases bacterial load in open contaminated wounds of the lower extremities. It can be used as a temporizing measure to manage bacterial colonization while patients and wounds are being prepared for final wound reconstruction.
C1 [Hahn, Hyung Min; Lee, Il Jae] Ajou Univ, Coll Med, Dept Plast & Reconstruct Surg, Seoul, South Korea.
   [Woo, Kyong-je; Park, Bo Young] Ewha Womans Univ, Sch Med, Dept Plast & Reconstruct Surg, Seoul, South Korea.
C3 Ajou University; Ewha Womans University
RP Hahn, HM (通讯作者)，Ajou Univ, Coll Med, Dept Plast & Reconstruct Surg, Seoul, South Korea.
RI ; Woo, KyongJe/IRZ-3509-2023
OI Park, Bo Young/0000-0003-4612-6672; 
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute - Ministry of Health & Welfare, Republic of Korea
   [HI16C0966]
FX This research was supported by a grant of the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute,
   funded by the Ministry of Health & Welfare, Republic of Korea (grant
   HI16C0966).
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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   Eldad Arieh, 2003, Harefuah, V142, P834
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   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
NR 17
TC 15
Z9 21
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2019
VL 32
IS 8
BP 370
EP 377
DI 10.1097/01.ASW.0000569116.59534.a6
PG 8
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA IL0UO
UT WOS:000477015600007
PM 31335434
DA 2026-07-24
ER
PT J
AU Wynn, M
   Freeman, S
AF Wynn, Matthew
   Freeman, Samantha
TI The efficacy of negative pressure wound therapy for diabetic foot
   ulcers: A systematised review
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Review
DE Diabetic foot ulcer; Negative pressure wound therapy; Vac dressing;
   Wound care; Diabetic foot disease
ID CLASSIFICATION-SYSTEM; AREA
AB Aim: This review investigated the current state of knowledge on negative pressure wound therapy (NPWT) used to treat diabetic foot ulceration (DFU), its clinical effectiveness and any current issues in the research. NICE have recommended research into the clinical effectiveness of different dressing types for DFUs since 2015.
   Methods: A systematic search of the British Nursing Index, CINAHL, Cochrane Central and PubMed was undertaken. Only primary studies were included and studies investigating a combination of NPWT and other therapies were excluded. All the included studies were published in English between 2008 and 2018 and were peer reviewed.
   Results: The search yielded seven studies for inclusion in the qualitative analysis. The studies included a variety of methodologies specifically; 3 randomized controlled trials, 2 case series', 1 non-controlled trial and 1 randomized case-control study. Three main themes were identified and formed the focus of the qualitative synthesis.
   Discussion: All the included studies reported that NPWT led to better clinical outcomes when compared to standard treatment. However, the studies had numerous methodological flaws such as the absence of validated tools for the measurement of outcomes such as wound area and depth; a lack of statistical power calculations to determine adequate sample sizes or the significance of outcome measures. Additionally, there was little consistency in the pressures used for the NPWT devices. Finally, many of the controlled trials did not conform to the standard of reporting trials stipulated by the CONSORT statement.
C1 [Wynn, Matthew; Freeman, Samantha] Univ Manchester, Oxford Rd, Manchester M13 9PL, Lancs, England.
C3 University of Manchester
RP Wynn, M (通讯作者)，Univ Manchester, Oxford Rd, Manchester M13 9PL, Lancs, England.
EM matthew.wynn@mft.nhs.uk; Samantha.freeman@manchester.ac.uk
RI ; Freeman, Samantha/AAD-6938-2020
OI Wynn, Matthew/0000-0001-9021-4747; Freeman, Samantha/0000-0002-1290-9145
CR [Anonymous], DIAB PREV MOD
   [Anonymous], NAT DIAB FOOT CAR AU
   [Anonymous], WOUND REPAIR REGEN
   [Anonymous], MANAGEMENT DIABETIC
   [Anonymous], PUSH TOOL
   [Anonymous], NEGATIVE PRESSURE WO
   [Anonymous], APPR EV
   [Anonymous], NEG PRESS WOUND THER
   [Anonymous], WOUND CARE ESSENTIAL
   [Anonymous], 2010, CONSORT STAT
   [Anonymous], PRISMA GROUP PREFERR
   [Anonymous], INT BEST PRACT GUID
   [Anonymous], NEW REG MED DEV
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NR 58
TC 46
Z9 55
U1 2
U2 37
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD AUG
PY 2019
VL 28
IS 3
BP 152
EP 160
DI 10.1016/j.jtv.2019.04.001
PG 9
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA IM1XN
UT WOS:000477785300005
PM 31056407
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Su, LL
   Zheng, JP
   Wang, Y
   Zhang, W
   Hu, DH
AF Su, Linlin
   Zheng, Jianping
   Wang, Yang
   Zhang, Wei
   Hu, Dahai
TI Emerging progress on the mechanism and technology in wound repair
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Wound repair; Inflammation; Immunity; Tissue engineering; Stem cells
ID ACELLULAR DERMAL MATRIX; STEM-CELLS; BREAST RECONSTRUCTION; SKIN; BURN;
   THERAPY; FIBRIN; FUTURE; KERATINOCYTES; REGENERATION
AB Normal wound repair is a dynamic and complex process involving multiple coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure during the repair process may cause chronic wounds or scar formation, which increase the financial burden of patients due to repetitive treatments and considerable medical expenditures, and affect their quality of life. Nowadays, extensive efforts have been made to develop novel therapeutics for wound repair. Genetic engineering technology, tissue engineering technology, stem cell-based therapy, physical and biochemical technology, and vacuum-assisted closure technique have been proposed to be beneficial for wound repair, and shown considerable potential for improving the rate and quality of wound healing and skin regeneration. However, challenges remain as applying these techniques. As the development of cell biology and molecular biology, the understanding of the mechanism under wound repair has gradually deepened. As the growth of interdisciplinary research on physics, chemistry, biology, tissue engineering, and materials, the concept and technique relating wound repair for clinical application have rapidly developed. This article reviews the latest progress on the mechanism and technique in wound repair.
C1 [Su, Linlin; Zhang, Wei; Hu, Dahai] Fourth Mil Med Univ, Xijing Hosp, Dept Burnsand Cutaneous Surg, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
   [Zheng, Jianping] Hubei Univ Arts & Sci, Affiliated Hosp, Xianyang Cent Hosp, Dept Orthoped Surg, Xiangyang 441021, Hubei, Peoples R China.
   [Wang, Yang] Xian Cent Hosp, Dept Burns & Plast Surg, Xian 710000, Shaanxi, Peoples R China.
C3 Air Force Medical University; Hubei University of Arts & Science
RP Su, LL (通讯作者)，Fourth Mil Med Univ, Xijing Hosp, Dept Burnsand Cutaneous Surg, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
EM linlinsu@fmmu.edu.cn
FU Shaanxi Province Key Research & Development Projects [2017kw-043];
   Talent Support Program of Air Force Military Medical University "Project
   Ling Yun"
FX This work was supported by Shaanxi Province Key Research & Development
   Projects (No: 2017kw-043 to L.S.), and the Talent Support Program of Air
   Force Military Medical University "Project Ling Yun" (No: cyjhsll to
   L.S.).
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NR 68
TC 77
Z9 84
U1 1
U2 78
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2019
VL 117
AR 109191
DI 10.1016/j.biopha.2019.109191
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IM2EA
UT WOS:000477804500035
PM 31387187
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lv, ZM
   Yu, LL
   Wang, QS
   Jia, R
   Ding, WY
   Shen, Y
AF Lv, Zhenmu
   Yu, Lili
   Wang, Qiusheng
   Jia, Rui
   Ding, Wenyuan
   Shen, Yong
TI Dermal regeneration template and vacuum sealing drainage for treatment
   of traumatic degloving injuries of upper extremity in a single-stage
   procedure
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE bone; tendon exposure; degloving injury; dermal regeneration template;
   vacuum sealing drainage
ID ARTIFICIAL DERMIS; RECONSTRUCTION; HAND; FOREARM; INTEGRA; SKIN;
   MANAGEMENT; DEFECTS
AB Background This study aimed to assess the efficacy and safety of a single-stage procedure using single-layer Pelnac and defatted avulsed skin for the management of degloving injuries of the forearm and hand. Methods This is a prospective study conducted from March 2013 to May 2017. A total of 15 consecutive patients with degloving injuries of the forearm and hand were treated with a single-stage procedure using single-layer Pelnac and defatted avulsed skin as a split-thickness skin graft. Post-operatively, scheduled follow-up was conducted. Results The overall 'take' rate of the Pelnac dermal template and the skin graft was 85-100%. No infections, haematoma or seroma were observed during hospitalization and after discharge. At the final follow-up, patients' subjective satisfaction with the aesthetic appearance of the grafted areas was, on average, 71.0 (SD 8.0, range 55-92). The Vancouver Scar Scale value was 2.1 (SD 1.8, range 1.0-5.5), representing a good result. The response of 'normal or near normal' to the sensory recovery was obtained for 13 patients and 'slight loss' for two patients. The average Disabilities of the Arm, Shoulder and Hand score was 21.2 (SD 13.5, range 0-53), and most patients (14/15) regained the ability to perform the daily activities without pain or restriction by tissue adhesion. Conclusion This single-stage procedure represents an effective technique for the management of degloving injuries of the forearm and hand and should be considered an alternative to other reconstructive procedures.
C1 [Lv, Zhenmu; Wang, Qiusheng; Jia, Rui; Shen, Yong] Peoples Liberat Army, Hosp 252, Dept Hand & Foot Surg, Shijiazhuang, Hebei, Peoples R China.
   [Lv, Zhenmu; Ding, Wenyuan] Hebei Med Univ, Hosp 3, Dept Spine Surg, 139 Zigiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
   [Yu, Lili] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Hebei, Peoples R China.
   [Ding, Wenyuan; Shen, Yong] Key Lab Biomech Hebei Prov, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Shen, Y (通讯作者)，Hebei Med Univ, Hosp 3, Dept Spine Surg, 139 Zigiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
EM drshenyongspine@126.com
OI Ding, Wenyuan/0000-0002-7257-4316
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NR 24
TC 7
Z9 9
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD JUL
PY 2019
VL 89
IS 7-8
BP 950
EP 954
DI 10.1111/ans.15315
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IN5UI
UT WOS:000478741700055
PM 31230422
DA 2026-07-24
ER
PT J
AU Huisman, JF
   van Westreenen, HL
   van der Wouden, EJ
   Vasen, HFA
   de Graaf, EJR
   Doornebosch, PG
   Tang, TJ
   Schot, I
   Brohet, RM
   Cappel, WHDTN
   Vermaas, M
AF Huisman, J. F.
   van Westreenen, H. L.
   van der Wouden, E. J.
   Vasen, H. F. A.
   de Graaf, E. J. R.
   Doornebosch, P. G.
   Tang, T. J.
   Schot, I.
   Brohet, R. M.
   Cappel, W. H. de Vos Tot Nederveen
   Vermaas, M.
TI Effectiveness of endosponge therapy for the management of presacral
   abscesses following rectal surgery
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE Rectal neoplasms; Anastomotic leak; Endosponge; Patient reported outcome
   measures; LARS score
ID LOW ANTERIOR RESECTION; VACUUM-ASSISTED CLOSURE; ENDO-SPONGE TREATMENT;
   ANASTOMOTIC LEAKAGE; CANCER; SINUS; RISK
AB Background Anastomotic leak after rectal surgery is reported in 9% (range 3-28%) of patients. The aim of our study was to evaluate the effectiveness of endosponge therapy for anastomotic. Endpoints were the rate of restored continuity and the functional bowel outcome after anastomotic leakage. Methods This was a multicenter retrospective observational cohort study. All patients with symptomatic anastomotic leakage after rectal surgery who had endosponge therapy between January 2012 and August 2017 were included. Functional bowel outcome was measured using the low anterior resection syndrome (LARS) score system. Results Twenty patients were included. Eighteen patients had low anterior resection (90%) for rectal cancer. A diverting ileostomy was performed at primary surgical intervention in 14 patients (70%). Fourteen patients (70%) were treated with neoadjuvant (chemo-)radiotherapy. The median time between primary surgical intervention and first endosponge placement was 21 (5-537) days. The median number of endosponge changes was 9 (2-28). The success rate of the endosponge treatment was 88% and the restored gastrointestinal continuity rate was 73%. A chronic sinus occurred in three patients (15%). All patients developed LARS, of which 77% reported major LARS. Conclusions Endosponge therapy is an effective treatment for the closure of presacral cavities with high success rate and leading to restored gastrointestinal continuity in 73%. However, despite endosponge therapy many patients develop major LARS.
C1 [Huisman, J. F.; van der Wouden, E. J.; Cappel, W. H. de Vos Tot Nederveen] Isala, Dept Gastroenterol & Hepatol, Zwolle, Netherlands.
   [van Westreenen, H. L.] Isala, Dept Surg, Zwolle, Netherlands.
   [Vasen, H. F. A.] Leiden Univ, Med Ctr, Dept Gastroenterol & Hepatol, Leiden, Netherlands.
   [de Graaf, E. J. R.; Doornebosch, P. G.; Vermaas, M.] IJsselland Hosp, Dept Surg, Capelle aan den IJssel, Netherlands.
   [Tang, T. J.; Schot, I.] IJsselland Hosp, Dept Gastroenterol & Hepatol, Capelle aan den IJssel, Netherlands.
   [Brohet, R. M.] Isala, Dept Epidemiol & Stat, Zwolle, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC)
RP Huisman, JF (通讯作者)，Isala, Dept Gastroenterol & Hepatol, Zwolle, Netherlands.
EM j.f.huisman@isala.nl
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   Nagell CF, 2006, INT J COLORECTAL DIS, V21, P657, DOI 10.1007/s00384-005-0083-4
   Qu H, 2015, SURG ENDOSC, V29, P3608, DOI 10.1007/s00464-015-4117-x
   Riss S, 2010, WORLD J GASTROENTERO, V16, P4570, DOI 10.3748/wjg.v16.i36.4570
   Snijders HS, 2012, EJSO-EUR J SURG ONC, V38, P1013, DOI 10.1016/j.ejso.2012.07.111
   Strangio G, 2015, DIGEST LIVER DIS, V47, P465, DOI 10.1016/j.dld.2015.02.007
   Sturiale A, 2017, INT J COLORECTAL DIS, V32, P83, DOI 10.1007/s00384-016-2659-6
   van Koperen PJ, 2011, COLORECTAL DIS, V13, P26, DOI 10.1111/j.1463-1318.2010.02377.x
   van Koperen PJ, 2009, SURG ENDOSC, V23, P1379, DOI 10.1007/s00464-008-0186-4
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
   Wu SW, 2014, WORLD J GASTROENTERO, V20, P18031, DOI 10.3748/wjg.v20.i47.18031
NR 19
TC 17
Z9 18
U1 0
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD JUN
PY 2019
VL 23
IS 6
BP 551
EP 557
DI 10.1007/s10151-019-02007-9
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA IN6DE
UT WOS:000478766000005
PM 31338710
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Magistri, P
   Olivieri, T
   Serra, V
   Tarantino, G
   Assirati, G
   Pecchi, A
   Ballarin, R
   Di Benedetto, F
AF Magistri, Paolo
   Olivieri, Tiziana
   Serra, Valentina
   Tarantino, Giuseppe
   Assirati, Giacomo
   Pecchi, Annarita
   Ballarin, Roberto
   Di Benedetto, Fabrizio
TI Vacuum-assisted management of surgical site infections after liver
   transplantation: 15-year experience in a tertiary hepatobiliary center
SO UPDATES IN SURGERY
LA English
DT Article
DE Wound healing; Vacuum therapy; Vacuum-assisted therapy; Vacuum-assisted
   closure; SSI; VAC
ID PRESSURE WOUND THERAPY; RISK-FACTORS; ASSOCIATION; RECIPIENTS; IMPACT
AB Immune compromised as well as critically ill patients are at higher risk of surgical wound infection and dehiscence. Wound infections critically influence the outcomes after liver transplantation. In particular, it was shown that they significantly reduce the overall survival rate when compared to patients with uneventful wound healing, and their occurrence is associated with death or graft loss within 1-year post-transplantation. From January 2001 through December 2017, 763 patients underwent liver transplantation in our Institution, the Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, "Policlinico" University Hospital, University of Modena and Reggio Emilia, Modena, Italy. We retrospectively analyzed data from our prospectively maintained database of patients treated with a negative pressure therapy device due to wound or abdominal infections. 13 patients underwent negative pressure treatments for surgical site infection after liver transplantation in our institution. Ten superficial "supra-fascial" applications (SF group) and three deeper abdominal (Ab group) were reported. Mean in-hospital stay for the SF group was 42.6 days, ranging from 8 to 80, while for the Ab group was 62 days (range 23-133), with an overall survival of 34 and 4.6 months, respectively. A multifactorial multidisciplinary approach is needed in the prevention of surgical site infections instead of mere antimicrobial prophylaxis The application of negative pressure wound therapy may help in controlling the diffusion of the infection and preventing sepsis.
C1 [Magistri, Paolo; Olivieri, Tiziana; Serra, Valentina; Tarantino, Giuseppe; Assirati, Giacomo; Ballarin, Roberto; Di Benedetto, Fabrizio] Univ Modena & Reggio Emilia, Hepatopancreatobiliary Surg Surg Oncol & Liver Tr, Via Pozzo 71, I-41124 Modena, MO, Italy.
   [Magistri, Paolo] Sapienza Univ Rome, Dept Med & Surg Sci & Translat Med, Rome, Italy.
   [Pecchi, Annarita] Univ Modena & Reggio Emilia, Dept Radiol, Modena, Italy.
C3 Universita di Modena e Reggio Emilia; Sapienza University Rome;
   Universita di Modena e Reggio Emilia
RP Di Benedetto, F (通讯作者)，Univ Modena & Reggio Emilia, Hepatopancreatobiliary Surg Surg Oncol & Liver Tr, Via Pozzo 71, I-41124 Modena, MO, Italy.
EM fabrizio.dibenedetto@unimore.it
RI Pecchi, Annarita/M-2559-2016; Tarantino, Giuseppe/AAD-1064-2022; Di
   Benedetto, Fabrizio/B-8388-2015; Magistri, Paolo/C-4425-2016
OI Pecchi, Annarita/0000-0001-8142-3256; Tarantino,
   Giuseppe/0000-0001-8102-6293; Di Benedetto,
   Fabrizio/0000-0002-6718-8760; Magistri, Paolo/0000-0001-8326-069X
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Almeida RAMB, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010164.pub2
   [Anonymous], COCHRANE DATABASE SY
   Asensio A, 2008, LIVER TRANSPLANT, V14, P799, DOI 10.1002/lt.21435
   Assirati G, 2016, TRANSPL P, V48, P383, DOI 10.1016/j.transproceed.2015.12.037
   Avkan-Oguz V, 2013, TRANSPL P, V45, P993, DOI 10.1016/j.transproceed.2013.02.067
   Chan T, 2018, AM J SURG, V215, P782, DOI 10.1016/j.amjsurg.2017.12.012
   Cockbain AJ, 2010, TRANSPL P, V42, P4181, DOI 10.1016/j.transproceed.2010.09.026
   Demetriades D, 2014, SURG CLIN N AM, V94, P131, DOI 10.1016/j.suc.2013.10.010
   Dondossola D, 2015, TRANSPL P, V47, P2145, DOI 10.1016/j.transproceed.2014.11.078
   Fishman JA, 2011, LIVER TRANSPLANT, V17, pS34, DOI 10.1002/lt.22378
   Prado MEG, 2008, TRANSPLANTATION, V85, P1849, DOI 10.1097/TP.0b013e3181735407
   Hellinger WC, 2011, AM J TRANSPLANT, V11, P1877, DOI 10.1111/j.1600-6143.2011.03644.x
   Hellinger WC, 2009, TRANSPLANTATION, V87, P1387, DOI 10.1097/TP.0b013e3181a25133
   Hobeika C, 2017, WORLD J SURG, V41, P3199, DOI 10.1007/s00268-017-4125-1
   Humar A, 2001, TRANSPLANTATION, V72, P1920, DOI 10.1097/00007890-200112270-00009
   Peinemann F, 2011, DTSCH ARZTEBL INT, V108, P381, DOI 10.3238/arztebl.2011.0381
   Peinemann F, 2011, J WOUND CARE, V20, P88, DOI 10.12968/jowc.2011.20.2.88
   Pignatti M, 2013, PATIENT SAF SURG, V7, DOI 10.1186/1754-9493-7-28
   Zanus G, 2011, TRANSPL INT, V24, pe23, DOI 10.1111/j.1432-2277.2010.01198.x
NR 20
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD SEP
PY 2019
VL 71
IS 3
BP 457
EP 462
DI 10.1007/s13304-018-0583-8
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IO3AJ
UT WOS:000479252600008
PM 30143984
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Renno, I
   Boos, AM
   Horch, RE
   Ludolph, I
AF Renno, Isabell
   Boos, Anja M.
   Horch, Raymund E.
   Ludolph, Ingo
TI Changes of perfusion patterns of surgical wounds under application of
   closed incision negative pressure wound therapy in postbariatric
   patients
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Skin perfusion patterns; combined laser Doppler spectrophotometry; ICG
   angiography; oxygen saturation; relative hemoglobin content; wound
   healing; O2C; SPY; weight loss; obesity; maintenance of weight loss;
   body contouring surgery; abdominoplasty; postoperative complications;
   closed incisional negative pressure wound therapy; ciNPWT; ciNPT; NPWT;
   postbariatric surgery; postoperative wound care; high-risk patients
ID LASER-DOPPLER SPECTROPHOTOMETRY; ABDOMINAL-WALL PERFUSION; BREAST
   RECONSTRUCTION; TISSUE PERFUSION; BLOOD-FLOW; BODY-MASS; COMPLICATIONS;
   ABDOMINOPLASTY; SURGERY; OUTCOMES
AB BACKGROUND: Negative pressure wound therapy applied over closed incisions (ciNPT) has been shown to influence wound healing. Therefore, the aim of this study was to examine the short-term effects of ciNPT on skin perfusion patterns in postbariatric wounds.
   METHODS: 17 patients were included. Patients from the study group received a ciNPT dressing with a continuous negative pressure of -125 mmHg for five days. Two intra- and two postoperative measurements were performed using both a combined laser Doppler spectrophotometry and an ICG angiography system to determine oxygen saturation (sO2), hemoglobin content (rHb) and perfusion patterns.
   RESULTS: Three days postoperatively the sO2 was significantly higher in the study group compared to the control group and also compared to the end of the operation. Concerning the rHb, there was no statistical significant alteration in or between the groups, but a trend towards a correlated alteration of sO2 and rHb. ICG angiography showed an earlier and stronger enhancement of perfusion parameters in the study group.
   CONCLUSION: CiNPT has a positive effect on oxygen saturation and tissue perfusion, which are both associated with the wound healing process. The use of ciNPT could therefore possibly reduce the risk of wound healing complications in this high-risk patient group.
C1 [Renno, Isabell; Boos, Anja M.; Horch, Raymund E.; Ludolph, Ingo] Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Plast & Hand Surg, Univ Hosp Erlangen, Erlangen, Germany.
   [Boos, Anja M.] Rhein Westfal TH Aachen, Dept Plast Surg Hand & Burn Surg, Univ Hosp Aachen, Aachen, Germany.
C3 University of Erlangen Nuremberg; RWTH Aachen University; RWTH Aachen
   University Hospital
RP Ludolph, I (通讯作者)，Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Plast & Hand Surg, Univ Hosp Erlangen, Erlangen, Germany.
EM ingo.ludolph@uk-erlangen.de
RI Horch, Raymund/H-8128-2019
FU Baxter AG Vienna; KCI-Acelity, Wiesbaden, Germany
FX Another author has received grants for scientific studies from
   KCI-Acelity, Wiesbaden, Germany and Baxter AG Vienna, and has acted as a
   lecturer and as an advisor for KCI-Acelity Wiesbaden and San Antonio,
   and has acted as an invited speaker for Novadaq, Germany.
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
   Araco A, 2009, ANN PLAS SURG, V62, P613, DOI 10.1097/SAP.0b013e3181856d85
   Araco A, 2008, PLAST RECONSTR SURG, V121, p305E, DOI 10.1097/PRS.0b013e31816b13c2
   Aung T, 2018, CLIN HEMORHEOLOGY MI
   Beckert S, 2004, DIABETES CARE, V27, P2863, DOI 10.2337/diacare.27.12.2863
   Beier JP, 2013, J PLAST RECONSTR AES, V66, P73, DOI 10.1016/j.bjps.2012.08.040
   Bercial ME, 2012, AESTHET PLAST SURG, V36, P370, DOI 10.1007/s00266-011-9807-8
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
   Burnier P, 2017, J PLAST RECONSTR AES, V70, P814, DOI 10.1016/j.bjps.2017.01.020
   Colquitt JL, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003641.pub4
   Colvard B, 2016, J VASC SURG, V64, P195, DOI 10.1016/j.jvs.2016.01.039
   Condé-Green A, 2013, ANN PLAS SURG, V71, P394, DOI 10.1097/SAP.0b013e31824c9073
   Coon D, 2009, ANN SURG, V249, P397, DOI 10.1097/SLA.0b013e318196d0c6
   Dragu A, 2012, OBESITY FACTS, V5, P651, DOI 10.1159/000343662
   Dragu A, 2011, OBES SURG, V21, P1781, DOI 10.1007/s11695-010-0328-3
   Dragu A, 2009, OBES SURG, V19, P1599, DOI 10.1007/s11695-008-9559-y
   Botero AG, 2017, ANN PLAS SURG, V79, P293, DOI 10.1097/SAP.0000000000001109
   Giordano SA, 2017, PLAST RECONSTR SURG, V139, P1234, DOI 10.1097/PRS.0000000000003264
   Horch RE, 2015, J WOUND CARE, V24, P21, DOI 10.12968/jowc.2015.24.Sup4b.21
   Jung EM, 2009, CLIN HEMORHEOL MICRO, V43, P19, DOI 10.3233/CH-2009-1218
   Ludolph I, 2016, J PLAST RECONSTR AES, V69, P1382, DOI 10.1016/j.bjps.2016.07.014
   Ma ZJ, 2017, INT J MOL MED, V40, P1415, DOI 10.3892/ijmm.2017.3131
   Mayr M, 2004, PLAST RECONSTR SURG, V114, P1586, DOI 10.1097/01.PRS.0000138757.33998.EE
   Michaels J, 2011, PLAST RECONSTR SURG, V127, P1693, DOI 10.1097/PRS.0b013e31820a649f
   Michaels J, 2011, PLAST RECONSTR SURG, V127, P1352, DOI 10.1097/PRS.0b013e3182063144
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Neaman KC, 2007, ANN PLAS SURG, V58, P292, DOI 10.1097/01.sap.0000239806.43438.54
   Neaman KC, 2013, PLAST RECONSTR SURG, V131, p403E, DOI 10.1097/PRS.0b013e31827c6fc3
   Neumann J, 2018, CLIN HEMORHEOL MICRO, V70, P69, DOI 10.3233/CH-170321
   Phillips BT, 2012, PLAST RECONSTR SURG, V129, p778E, DOI 10.1097/PRS.0b013e31824a2ae8
   Pollock H, 2000, PLAST RECONSTR SURG, V105, P2583, DOI 10.1097/00006534-200006000-00047
   Rothenberger J, 2013, MICROSURG, V33, P350, DOI 10.1002/micr.22096
   Song P, 2016, ANN PLAS SURG, V76, pS216, DOI 10.1097/SAP.0000000000000788
   Suh H, 2016, ANN PLAS SURG, V76, P717, DOI 10.1097/SAP.0000000000000231
   Warner JP, 2009, PLAST RECONSTR SURG, V124, P926, DOI 10.1097/PRS.0b013e3181b03880
   Xia CY, 2014, MOL MED REP, V9, P1749, DOI 10.3892/mmr.2014.1997
   Zimmermann A, 2012, CLIN HEMORHEOL MICRO, V50, P157, DOI 10.3233/CH-2011-1408
NR 37
TC 25
Z9 28
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2019
VL 72
IS 2
BP 139
EP 150
DI 10.3233/CH-180450
PG 12
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA IO3VW
UT WOS:000479309800004
PM 30664503
DA 2026-07-24
ER
PT J
AU Inatomi, Y
   Kadota, H
   Kamizono, K
   Hanada, M
   Yoshida, S
AF Inatomi, Yusuke
   Kadota, Hideki
   Kamizono, Kenichi
   Hanada, Masuo
   Yoshida, Sei
TI Securing split thickness skin grafts using negative-pressure wound
   therapy without suture fixation
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE graft shearing; negative-pressure wound therapy (NPWT); no suture; skin
   graft fixation; split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE
AB Objective: Negative-pressure wound therapy (NPWT) is generally applied as a bolster for split-thickness skin grafts (STSG) after the graft has been secured with sutures or skin staples. In this study, NPWT was applied to secure STSGs without any sutures or staples. Surgical outcomes of using NPWT without sutures was compared with a control group.
   Methods: Patients with STSGs were divided into two groups: a 'no suture' group using only NPWT, and a control group using conventional fixings. In the no suture group, the grafts were covered with meshed wound dressing and ointment. The NPWT foam was placed over the STSG and negative pressure applied. In the control group, grafts were fixed in place using tie-over bolster, securing with fibrin glue, or NPWT after sutures.
   Results: A total of 30 patients with 35 graft sites participated in the study. The mean rate of graft take in the no suture group was 95.1%, compared with 93.3% in the control group, with no significant difference between them. No graft shearing occurred in the no suture group. Although the difference did not reach statistical significance, mean surgical time in the no suture group (31.5 minutes) tended to be shorter than that in the control group (55.7 minutes).
   Conclusion: By eliminating sutures, the operation time tended to be shorter, suturing was avoided and suture removal was not required meaning that patients could avoid the pain associated with this procedure. Furthermore, the potential for staple retention and its associated complications was avoided, making this method potentially beneficial for both medical staff and patients.
C1 [Inatomi, Yusuke; Kadota, Hideki; Kamizono, Kenichi; Hanada, Masuo; Yoshida, Sei] Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, Higashi Ku, Fukuoka, Fukuoka, Japan.
C3 Kyushu University
RP Inatomi, Y (通讯作者)，Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, Higashi Ku, Fukuoka, Fukuoka, Japan.
EM xkxmy557@gmail.com
RI /AAU-7710-2020
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Evangelista Maristella S, 2013, Wounds, V25, P89
   Hudson DA, 2015, INT WOUND J, V12, P195, DOI 10.1111/iwj.12080
   Inatomi Y, 2015, JPN J PLAST RECON SU, V35, P487
   Klink CD, 2011, BMC SURG, V11, DOI 10.1186/1471-2482-11-36
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
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NR 10
TC 9
Z9 13
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG 1
PY 2019
VL 28
IS 8
SU S
BP S16
EP S21
DI 10.12968/jowc.2019.28.Sup8.S16
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IP8NV
UT WOS:000480304000003
PM 31393782
DA 2026-07-24
ER
PT J
AU Stenqvist, CP
   Nielsen, CT
   Napolitano, GM
   Larsen, BM
   Flies, MJ
   Brander, DC
   Lynge, E
   Pallesen, P
AF Stenqvist, Charlotte P.
   Nielsen, Camilla T.
   Napolitano, George M.
   Larsen, Bo M.
   Flies, Mitchell J.
   Brander, Ditte C.
   Lynge, Elsebeth
   Pallesen, Per
TI Does closed incision negative wound pressure therapy in non-traumatic
   major lower-extremity amputations improve survival rates?
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE amputation; diabetes; infection
ID LOWER-LIMB AMPUTATION; GENERAL-ANESTHESIA; MORTALITY; RISK
AB Closed incision negative pressure wound therapy (CINPWT) has been shown to be clinically effective compared with the traditional gauze dressing, reducing surgical site infections and wound complications. We evaluated the effect of CINPWT compared with gauze dressing on the need for revision surgery and survival after non-traumatic major lower amputation. We included 309 patients undergoing 403 major lower amputations in a retrospective study from January 1, 2010 to November 23, 2017. A total of 139 patients received CINPWT, and 170 patients received stump bandage. There was no statistically significant difference between the two groups regarding the need for revision surgery (P = .45). Fourteen stump bandage patients and 15 CINPWT patients died in hospital (P = .57). One year after amputation, 55 CINPWT patients and 66 stump bandage patients had died (P = .82). Survival probabilities adjusted for age and gender 2 years after amputation were .52 (.43-.61) and .49 (.42-.58), respectively, and 3 years after amputation were .36 (.25-.50) and .39 (.32-.47), respectively. We also found no significant difference in the need for revision surgery in survival probabilities up till 3 years after amputation between patients treated with CINPWT and patients treated with gauze bandage postoperatively.
C1 [Stenqvist, Charlotte P.; Nielsen, Camilla T.; Larsen, Bo M.; Flies, Mitchell J.; Brander, Ditte C.; Pallesen, Per] Nykoebing Falster Hosp, Dept Orthoped Surg, Nykoebing Falster, Denmark.
   [Napolitano, George M.] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark.
   [Lynge, Elsebeth] Univ Copenhagen, Nykoebing Falster Hosp, Ctr Epidemiol Res, Nykoebing Falster, Denmark.
C3 University of Copenhagen; University of Copenhagen
RP Stenqvist, CP (通讯作者)，Bentsensvej 12 A, DK-4330 Hvalso, Denmark.
EM charlotte_stenqvist@hotmail.com
OI Toft Nielsen, Camilla/0000-0003-1444-8730
CR Chery J, 2014, ANN VASC SURG, V28, P1149, DOI 10.1016/j.avsg.2013.07.033
   Gurney JK, 2018, DIABETOLOGIA, V61, P626, DOI 10.1007/s00125-017-4488-8
   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
   Jensen PS, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016030
   Jorgensen ME, 2014, DIABETIC MED, V31, P443, DOI 10.1111/dme.12320
   Kotha V, 2019, SURG TECHNOL INT, V34, P49
   Kristensen MT, 2016, ACTA ORTHOP, V87, P306, DOI 10.3109/17453674.2016.1167524
   Kristensen MT, 2015, DAN MED J, V62
   Kristensen MT, 2012, INTERACT CARDIOV TH, V14, P543, DOI 10.1093/icvts/ivr075
   Nam D, 2018, J AM ACAD ORTHOP SUR, V26, P295, DOI 10.5435/JAAOS-D-17-00054
   Niskakangas M, 2018, ACTA ANAESTH SCAND, V62, P226, DOI 10.1111/aas.13019
   Pachowsky M, 2012, INT ORTHOP, V36, P719, DOI 10.1007/s00264-011-1321-8
   Schmiegelow MT, 2018, DAN MED J, V65
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Stenqvist C, 2016, GERIATR ORTHOP SURG, V7, P67, DOI 10.1177/2151458515625296
   Wied C, 2015, UGESKR LAEGER, V177
   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
NR 17
TC 7
Z9 7
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2019
VL 16
IS 5
BP 1171
EP 1177
DI 10.1111/iwj.13176
EA AUG 2019
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA JG7RQ
UT WOS:000480641300001
PM 31407512
OA Green Submitted
DA 2026-07-24
ER
PT J
AU González, JAJ
   Sánchez, CQ
   Rodríguez, FM
AF Jerez Gonzalez, Jose Antonio
   Quinones Sanchez, Cristina
   Marquez Rodriguez, Francisca
TI Catastrophic Abdominal Wall After Repair of Enterocutaneous Fistula A
   Case Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Absorbent polyacrylate fibers; Enterocutaneous fistula; Negative
   pressure wound therapy; Skin graft
ID INTESTINAL FAILURE; OPEN ABDOMEN; METAANALYSIS; MANAGEMENT; CLOSURE
AB BACKGROUND: Repair of an enterocutaneous fistula (ECF) is challenging, particularly when complications occur. This case describes the use of negative pressure wound therapy (NPWT) and microadhesive dressings with polyabsorbent fibers and an acrylic core, with and without lipidocolloid and nano-oligosaccharide factors, in the management of a patient with a large abdominal wound and ECF.
   CASE: An 84-year-old woman underwent abdominoperineal resection with colostomy, hysterectomy, and subsequent chemotherapy and radiotherapy for colorectal cancer. She experienced complications, ultimately resulting in ECF of the jejunum. Initial management with NPWT was used to promote abdominal wound healing, while protecting exposed bowel loops proved challenging because of leakage of stoma effluent that impeded the formation of granulation tissue. In order to promote wound healing and prevent infection, we applied a microadhesive dressing composed of polyabsorbent fibers with an acrylic core and lipidocolloid and nano-oligosaccharide factors that facilitated autolytic debridement and healing.
   CONCLUSIONS: Use of NPWT with the microadhesive dressing proved successful in the management of this complex and challenging ECF.
C1 [Jerez Gonzalez, Jose Antonio; Quinones Sanchez, Cristina; Marquez Rodriguez, Francisca] Bellvitge Univ Hosp, C Feixa Llarga S-N, Barcelona 08907, Spain.
C3 University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge
   (IDIBELL); Bellvitge University Hospital
RP González, JAJ (通讯作者)，Bellvitge Univ Hosp, C Feixa Llarga S-N, Barcelona 08907, Spain.
EM jjerez@bellvitgehospital.cat
CR Adaba F, 2017, CLIN COLON RECT SURG, V30, P215, DOI 10.1055/s-0037-1598163
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   White R, 2011, SUPPORTING EVIDENCE
NR 15
TC 1
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2019
VL 46
IS 4
BP 337
EP 342
DI 10.1097/WON.0000000000000539
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA IQ4KC
UT WOS:000480718600015
PM 31274868
DA 2026-07-24
ER
PT J
AU Lv, ZM
   Yu, LL
   Fu, L
   Wang, QS
   Jia, R
   Ding, WY
   Shen, Y
AF Lv, Zhenmu
   Yu, Lili
   Fu, Lei
   Wang, Qiusheng
   Jia, Rui
   Ding, Wenyuan
   Shen, Yong
TI Revision surgery with dermal regeneration template and vacuum sealing
   drainage for reconstruction of complex wounds following necrosis of
   reattached avulsed skins in a degloving injury A case report
SO MEDICINE
LA English
DT Article
DE bone/tendon exposure; degloving injury; dermal regeneration template;
   pelnac; skin defect
ID NEGATIVE-PRESSURE THERAPY; ARTIFICIAL DERMIS; ASSISTED CLOSURE; TISSUE
   DEFECTS; INTEGRA
AB Rationale: Degloving injury of the upper limb often extends to underlying tendons and bone, which is at high risk of treatment failure if only simple reattachment of defatted avulsed skins was performed. Pelnac dermal regeneration template could be used as a treatment choice for necrosis of the reattached avulsed skins in a degloving injury.
   Patient concerns: A 48-year-old woman with a degloving injury of the right forearm, wrist, and hand received initial treatment by reattachment of the defatted avulsed skins over the wound bed. However, 17 days postoperatively, the reattached skins developed complete necrosis, leaving large size of tissue defects and tendon/bone exposure.
   Diagnosis: Failure to reconstruct the skin and soft-tissue envelop by reattachment of the defatted avulsed skins in a severe degloving injury of the upper limb.
   Interventions: We decided to use a 2-stage procedure of Pelnac dermal regeneration template and secondary skin graft to solve this issue, in consideration of these conditions and the patient' demanding of limb function and aesthetic appearance.
   Outcomes: At the final follow-up, this patient obtained an excellent result, in term of scar quality, aesthetic appearance, and the ability to perform the daily activities.
   Lessons: We believe this could become an interesting option in patients who needed revision procedure for management of complex wounds with tendon/bone exposure following the necrosis of reattached skins in degloving injuries.
C1 [Lv, Zhenmu; Wang, Qiusheng; Jia, Rui] 252 Hosp Peoples Liberat Army China, Dept Hand & Foot Surg, Shijiazhuang, Hebei, Peoples R China.
   [Lv, Zhenmu; Ding, Wenyuan; Shen, Yong] Hebei Med Univ, Hosp 3, Dept Spine Surg, 139 Zqiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
   [Yu, Lili] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Hebei, Peoples R China.
   [Fu, Lei; Ding, Wenyuan; Shen, Yong] Key Lab Biomech Hebei Prov, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Shen, Y (通讯作者)，Hebei Med Univ, Hosp 3, Dept Spine Surg, 139 Zqiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
EM drshenyongspine@126.com
OI Ding, Wenyuan/0000-0002-7257-4316
CR Bui DT, 2007, PLAST RECONSTR SURG, V119, P2092, DOI 10.1097/01.prs.0000260598.24376.e1
   Chen X, 2010, CLIN PLAST SURG, V63, P69
   Demiri E, 2013, ARCH ORTHOP TRAUM SU, V133, P1521, DOI 10.1007/s00402-013-1834-2
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   Jeng SF, 2004, PLAST RECONSTR SURG, V114, P1225, DOI 10.1097/01.PRS.0000135869.57955.36
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NR 20
TC 5
Z9 6
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN
PY 2019
VL 98
IS 23
AR e15864
DI 10.1097/MD.0000000000015864
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IQ4LD
UT WOS:000480721300024
PM 31169690
OA Green Published, gold
DA 2026-07-24
ER
PT J
AU Javed, AA
   Teinor, J
   Wright, M
   Ding, D
   Burkhart, RA
   Hundt, J
   Cameron, JL
   Makary, MA
   He, J
   Eckhauser, FE
   Wolfgang, CL
   Weiss, MJ
AF Javed, Ammar A.
   Teinor, Jonathan
   Wright, Michael
   Ding, Ding
   Burkhart, Richard A.
   Hundt, John
   Cameron, John L.
   Makary, Martin A.
   He, Jin
   Eckhauser, Frederic E.
   Wolfgang, Christopher L.
   Weiss, Matthew J.
TI Negative Pressure Wound Therapy for Surgical-site Infections A
   Randomized Trial
SO ANNALS OF SURGERY
LA English
DT Article
DE negative pressure wound therapy; pancreaticoduodenectomy; randomized
   controlled trial; surgical-site infections
ID HOSPITAL COSTS; COMPLICATIONS; PREDICTORS; SURGERY
AB Objective: This study seeks to evaluate the efficacy of negative pressure wound therapy for surgical-site infection (SSI) after open pancreaticoduodenectomy.
   Background: Despite improvement in infection control, SSIs remain a common cause of morbidity after abdominal surgery. SSI has been associated with an increased risk of reoperation, prolonged hospitalization, readmission, and higher costs. Recent retrospective studies have suggested that the use of negative pressure wound therapy can potentially prevent this complication.
   Methods: We conducted a single-center randomized, controlled trial evaluating surgical incision closure during pancreaticoduodenectomy using negative pressure wound therapy in patients at high risk for SSI. We randomly assigned patients to receive negative pressure wound therapy or a standard wound closure. The primary end point of the study was the occurrence of a postoperative SSI. We evaluated the economic impact of the intervention.
   Results: From January 2017 through February 2018, we randomized 123 patients at the time of closure of the surgical incision. SSI occurred in 9.7% (6/62) of patients in the negative pressure wound therapy group and in 31.1% (19/61) of patients in the standard closure group (relative risk = 0.31; 95% confidence interval, 0.13-0.73; P = 0.003). This corresponded to a relative risk reduction of 68.8%. SSIs were found to independently increase the cost of hospitalization by 23.8%.
   Conclusions: The use of negative pressure wound therapy resulted in a significantly lower risk of SSIs. Incorporating this intervention in surgical practice can help reduce a complication that significantly increases patient harm and healthcare costs.
C1 [Javed, Ammar A.; Teinor, Jonathan; Wright, Michael; Ding, Ding; Burkhart, Richard A.; Cameron, John L.; Makary, Martin A.; He, Jin; Eckhauser, Frederic E.; Wolfgang, Christopher L.; Weiss, Matthew J.] Johns Hopkins Univ Hosp, John L Cameron Div Hepatobiliary & Pancreat Surg, Baltimore, MD 21287 USA.
   [Javed, Ammar A.; Teinor, Jonathan; Wright, Michael; Ding, Ding; Burkhart, Richard A.; Hundt, John; Cameron, John L.; Makary, Martin A.; He, Jin; Eckhauser, Frederic E.; Wolfgang, Christopher L.; Weiss, Matthew J.] Johns Hopkins Univ Hosp, Dept Surg, Baltimore, MD 21287 USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins
   University; Johns Hopkins Medicine
RP Weiss, MJ (通讯作者)，Johns Hopkins Univ Hosp, 600 N Wolfe St,Blalock 685, Baltimore, MD 21287 USA.
EM mweiss5@jhmi.edu
RI ; Ding, Ding/AAB-3538-2021; Javed, Ammar/AAE-2870-2020; Wolfgang,
   Christopher/HGD-0863-2022
OI He, Jin/0000-0001-9149-2247; Hundt, John/0009-0006-2468-5632; Javed,
   Ammar/0000-0002-5463-5250; 
FU KCI/Acelity [125164]
FX KCI/Acelity (Grant number #125164).
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NR 29
TC 95
Z9 105
U1 2
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JUN
PY 2019
VL 269
IS 6
BP 1034
EP 1040
DI 10.1097/SLA.0000000000003056
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IQ4OM
UT WOS:000480730100015
PM 31082899
DA 2026-07-24
ER
PT J
AU Schlosser, KA
   Otero, J
   Lincourt, A
   Augenstein, VA
AF Schlosser, Kathryn A.
   Otero, Javier
   Lincourt, Amy
   Augenstein, Vedra A.
TI Management of Surgical Incisions Using Incisional Negative-Pressure
   Therapy
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COMPONENT SEPARATION TECHNIQUE; MICROVASCULAR
   BLOOD-FLOW; WOUND-THERAPY; SITE INFECTIONS; CLOSED INCISIONS; FINANCIAL
   IMPACT; HERNIA REPAIR; PREVENTION; CARE
AB Use of negative-pressure therapy (NPT) is a well-established therapy for chronic, open, contaminated wounds, promoting formation of granulation tissue and healing. The application of NPT after primary closure (ie, incisional NPT) has also been shown to reduce surgical site infection and surgical site occurrence in high-risk procedures across multiple disciplines. Incisional NPT is believed to decrease edema and shear stress, promote angiogenesis and lymphatic drainage, and increase vascular flow and scar formation. Incisional NPT may be considered when there is a high risk of surgical site occurrence or surgical site infection, particularly in procedures with nonautologous implants, such as hernia mesh or other permanent prosthetics. Here we discuss the proposed physiologic mechanism as demonstrated in animal models and review clinical outcomes across multiple specialties.
C1 [Schlosser, Kathryn A.; Otero, Javier; Lincourt, Amy; Augenstein, Vedra A.] Carolinas Med Ctr, Div Gastrointestinal & Minimally Invas Surg, Dept Surg, Charlotte, NC 28203 USA.
C3 Carolinas Medical Center
RP Augenstein, VA (通讯作者)，Carolinas Med Ctr, 1025 Morehead Med Dr,Suite 300, Charlotte, NC 28204 USA.
EM Vedra.Augenstein@atriumhealth.org
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NR 66
TC 17
Z9 18
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2019
VL 143
IS 1
SU S
BP 15S
EP 20S
DI 10.1097/PRS.0000000000005307
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IQ4PL
UT WOS:000480732600005
PM 30586098
DA 2026-07-24
ER
PT J
AU Agarwal, A
AF Agarwal, Animesh
TI Management of Closed Incisions Using Negative-Pressure Wound Therapy in
   Orthopedic Surgery
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID SURGICAL SITE INFECTIONS; INCREASES EARLY COMPLICATIONS; CARE-ASSOCIATED
   INFECTIONS; VACUUM-ASSISTED CLOSURE; BODY-MASS INDEX; OPERATIVE
   TREATMENT; KNEE ARTHROPLASTY; PRIMARY HIP; RISK; IMPACT
AB Negative-pressure wound therapy (NPWT) has been a major advance in the management of open wounds, especially in orthopedic trauma surgery. Due to the success of NPWT, surgeons began using NPWT on closed incisions as a way to help prevent surgical wound dehiscence, especially in at-risk patients for wound problems. It has been well established that obesity, diabetes mellitus, and smoking in addition to other comorbidities increase the risk of wound dehiscence and surgical site infections in orthopedic patients. This article reviews the current literature and provides an overview on the use of NPWT on closed incisions in orthopedic trauma procedures and joint arthroplasty.
C1 [Agarwal, Animesh] Univ Texas Hlth Sci Ctr San Antonio, Div Orthopaed Trauma, Dept Orthopaed, 7703 Floyd Curl Dr,MC7774, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas at San Antonio
RP Agarwal, A (通讯作者)，Univ Texas Hlth Sci Ctr San Antonio, Div Orthopaed Trauma, Dept Orthopaed, 7703 Floyd Curl Dr,MC7774, San Antonio, TX 78229 USA.
EM agarwal@uthscsa.edu
RI Agarwal, Animesh/AAG-5725-2020
OI Agarwal, Animesh/0000-0003-3287-3052
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NR 57
TC 13
Z9 15
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2019
VL 143
IS 1
SU S
BP 21S
EP 26S
DI 10.1097/PRS.0000000000005308
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IQ4PL
UT WOS:000480732600006
PM 30586099
DA 2026-07-24
ER
PT J
AU Murphy, PB
   Knowles, S
   Chadi, SA
   Vogt, K
   Brackstone, M
   Van Koughnett, JA
   Ott, MC
AF Murphy, Patrick B.
   Knowles, Sarah
   Chadi, Sami A.
   Vogt, Kelly
   Brackstone, Muriel
   Van Koughnett, Julie Ann
   Ott, Michael C.
TI Negative Pressure Wound Therapy Use to Decrease Surgical Nosocomial
   Events in Colorectal Resections (NEPTUNE) A Randomized Controlled
   Trial
SO ANNALS OF SURGERY
LA English
DT Article
DE colectomy; colon; negative pressure wound therapy; NPWT; SSI; surgical
   site infection
ID VACUUM-ASSISTED CLOSURE; SITE INFECTION; METAANALYSIS; PREVENTION;
   SURGERY; LAPAROTOMY; INCISIONS; DISEASE; SYSTEM
AB Objective: Determine if negative pressure wound therapy (NPWT) reduces surgical site infection (SSI) in primarily closed incision after open and laparoscopic-converted colorectal surgery.
   Background: SSIs after colorectal surgery are a common cause of morbidity. The prophylactic effect of NPWT has not been established. We undertook this study to evaluate if, among patients undergoing open colorectal resection, NPWT, as compared with standard postoperative dressings, is associated with a reduction in the rate of postoperative SSI.
   Methods: In a randomized, controlled trial, 300 patients undergoing elective open colorectal surgery were assigned to receive prophylactic NPWT or standard gauze dressing. The primary end-point was 30-day SSI, as assessed by wound care experts blinded to treatment arm. Secondary outcomes included length of stay. Statistical analysis was performed on an intention-to-treat basis. A priori subgroup analysis was planned for patients who received a stoma at the time of initial operation.
   Results: The incidence of SSI at 30-days postoperatively was no different between experimental and control groups (32% vs 34% respectively, P = 0.68). Length of stay was also no different at a median of 7 days (IQR 5) for both groups. Among patients receiving a stoma, there was also no difference in SSI between the experimental and control groups (38% vs 33% respectively, P = 0.66).
   Conclusions: Prophylactic use of NPWT on primarily closed incisions after open colorectal surgery was not associated with a decrease in SSI rate when compared with standard gauze dressing.
C1 [Murphy, Patrick B.; Knowles, Sarah; Chadi, Sami A.; Vogt, Kelly; Brackstone, Muriel; Van Koughnett, Julie Ann; Ott, Michael C.] Western Univ, Schulich Sch Med & Dent, Dept Surg, Div Gen Surg, London, ON, Canada.
C3 Western University (University of Western Ontario)
RP Murphy, PB (通讯作者)，Victoria Hosp, Div Gen Surg, London Hlth Sci Ctr, Room E2-214,800 Commissioners Rd East, London, ON N6A 5W9, Canada.
EM pbatesmurphy@gmail.com
RI Murphy, Patrick/T-5337-2019; Chadi, Sami/DWM-5165-2022
OI Ott, Michael/0000-0002-0816-7089
FU Kinetic Concepts Inc. (San Antonio, TX)
FX The study was funded by an industry grant from Kinetic Concepts Inc.
   (San Antonio, TX) in the amount of $ 87 000. The devices were also
   provided free of charge.
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NR 28
TC 64
Z9 68
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JUL
PY 2019
VL 270
IS 1
BP 38
EP 42
DI 10.1097/SLA.0000000000003111
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IQ4PQ
UT WOS:000480733100021
PM 30499799
DA 2026-07-24
ER
PT J
AU Li, XQ
   Zhang, F
   Liu, XJ
   Cao, ZL
   Liu, P
   Xia, L
   Du, M
AF Li, Xiuqi
   Zhang, Fan
   Liu, Xujin
   Cao, Zilong
   Liu, Pei
   Xia, Lin
   Du, Min
TI Staged Treatment of Chest Wall Radiation-Induced Ulcer With Negative
   Pressure Wound Therapy and Latissimus Dorsi Myocutaneous Flap
   Transplantation
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Chest wall reconstruction; latissimus dorsi myocutaneous flap; negative
   pressure wound therapy; radiation-induced ulcer; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTION
AB Chest wall ulcer induced by postmastectomy radiation therapy (PRMT) remains challenging for plastic surgeons because of the reduced blood supply, fibrosis, and impaired cellular potential in the irradiated area. In this study, chest wall ulcer was treated with negative pressure wound therapy (NPWT) and the latissimus dorsi myocutaneous (LDM) flap reconstruction in 2 stages. A retrospective study was performed on consecutive patients with chronic radiation-induced ulcers in chest wall from June 2012 to June 2017. Surgical debridement and NPWT were performed in the first stage and the chest wall reconstructed by the LDM flap transplantation after extensive debridement in the second stage. There were 10 female patients with chest wall ulcers with a mean age of 60.3 years. The average duration of the ulcers was 21.2 months and the ulcers varied from 1 x 2 to 5 x 7 cm(2). Histological examination denied any recurrent breast cancer or radiation-related malignancy. Negative pressure wound therapy was applied with 100 to 125mm Hg negative pressure during a period of 5 to 7 days in the first stage. The LDM flap varied from 11 x 15 to 15 x 20 cm(2). The mean follow-up was 25.9 months. All the flaps survived well with satisfactory appearance and there was no donor-site morbidity or ulcer recurrence during the follow-up period. The staged treatment of the chest wall radiation ulcer incorporated the benefits of NPWT and LDM flap. It is beneficial in increasing the blood and nutrient supply to the irradiated tissue, enhancing the debridement and promoting tissue healing, thus improving the flap survival and decreasing the ulcer recurrence.
C1 [Li, Xiuqi] Shandong Univ, Qilu Hosp, Dept Med Cosmetol, Jinan, Shandong, Peoples R China.
   [Zhang, Fan; Cao, Zilong; Liu, Pei; Xia, Lin; Du, Min] Shandong Univ, Qilu Hosp, Dept Burns & Plast Surg, 107 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
   [Liu, Xujin] Shandong Univ, Qilu Hosp, Dept Hepatol, Jinan, Shandong, Peoples R China.
C3 Shandong University; Shandong University; Shandong University
RP Zhang, F (通讯作者)，Shandong Univ, Qilu Hosp, Dept Burns & Plast Surg, 107 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
EM professorzhangfan@163.com
FU Key Research and Development Program of Shandong Province
   [2017GSF218048]
FX This study was supported by grants from the Key Research and Development
   Program of Shandong Province (No. 2017GSF218048).
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NR 18
TC 8
Z9 17
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD JUL-AUG
PY 2019
VL 30
IS 5
BP E450
EP E453
DI 10.1097/SCS.0000000000005514
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IQ4VC
UT WOS:000480748200026
PM 31299811
DA 2026-07-24
ER
PT J
AU Schreiter, NA
   McCarthy, DP
   Fiedler, AG
   Young, N
   Demarais, D
   Anagnostopoulos, PV
   Hermsen, JL
AF Schreiter, Nicholas A.
   McCarthy, Daniel P.
   Fiedler, Amy G.
   Young, Natasha
   Demarais, Dean
   Anagnostopoulos, Petros V.
   Hermsen, Joshua L.
TI Helpful sternal wound vacuum-assisted closure techniques in two open
   chest situations: Central extracorporeal membrane oxygenation and
   sternal infection
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
DE deep sternal wound infection; ECMO; mediastinitis; sternum; wound vac
AB Background Dressing open sternal wounds after cardiac surgery can be challenging. In cases where extracorporeal membrane oxygenation (ECMO) is required, the sternum is left open with cannulae traversing the wound, making it difficult to create a water-tight seal and maintain sterility. Patients with a deep sternal infection may also be left with an open sternum between the time of debridement and reconstruction; in such cases, stabilizing the dressing in an ambulatory patient can pose a challenge. Methods Two cases are reviewed, each highlighting the solutions to the problems mentioned above. Results In case 1, a patient with an open sternum and central ECMO, we describe construction of a dressing that achieves air seal and blood seal, and helps maintain the cannulae in a safe, stable position. In case 2, an ambulatory patient, we describe a modification of a recently published "Two Bridge Technique" that provides a stable dressing in three dimensions. Conclusion Performance of specific techniques and attention to detail in complex situations can make a big difference in open sternum patients treated with temporary, vacuum-assisted dressings. Achieving vacuum and fluid seal is important for sterility, integrity of adjacent skin, and caregiver safety.
C1 [Schreiter, Nicholas A.; McCarthy, Daniel P.; Fiedler, Amy G.; Young, Natasha; Demarais, Dean; Anagnostopoulos, Petros V.; Hermsen, Joshua L.] Univ Wisconsin, Dept Surg, Div Cardiothorac Surg, Madison, WI 53593 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Hermsen, JL (通讯作者)，Univ Wisconsin, Dept Surg, Div Cardiothorac Surg, Clin Sci Ctr, 600 Highland Ave,H4-352, Madison, WI 53593 USA.
EM hermsen@surgery.wisc.edu
OI Schreiter, Nicholas/0000-0002-9002-7367
CR Ennker IC, 2009, J CARDIOTHORAC SURG, V4, DOI 10.1186/1749-8090-4-5
   Waked K, 2018, INT WOUND J, V15, P198, DOI 10.1111/iwj.12823
NR 2
TC 2
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD NOV
PY 2019
VL 34
IS 11
BP 1150
EP 1153
DI 10.1111/jocs.14209
EA AUG 2019
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA JI1LP
UT WOS:000483233300001
PM 31441530
DA 2026-07-24
ER
PT J
AU Zhang, D
   Li, ZH
   Wang, Z
   Zeng, FW
   Xiao, WD
   Yu, AX
AF Zhang, Dong
   Li, Zonghuan
   Wang, Zheng
   Zeng, Fanwei
   Xiao, Weidong
   Yu, Aixi
TI MicroRNA-126: a promising biomarker for angiogenesis of diabetic wounds
   treated with negative pressure wound therapy
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE microRNA-126; negative-pressure wound therapy; diabetic wound healing
ID ENDOTHELIAL GROWTH-FACTOR; DOWN-REGULATION; INFLAMMATION; COMPLICATIONS;
   EXPRESSION; IMPAIRS; BLOOD
AB Background: Negative pressure wound therapy represents an effective therapy to treat nonhealing diabetic wounds by promoting angiogenesis, of which the mechanism hasn't been investigated thoroughly. Growing evidence suggests that miRNAs hold great potential to be clinical biomarkers, and miR-126 is an essential angiogenesis regulator in diabetic wound repair.
   Purpose: Our study aims to explore the effect of NPWT on the expression of miR-126 in the wound tissue and plasma of diabetic rat models and the association between circulating miR-126 and two quantitative indexes of angiogenesis.
   Methods: Full-thickness excisional wounds were created on the back of diabetic rats. Measure the wound closure and collect the wound tissue and blood for H&E, immunohistochemistry, Western blot and RT-PCR. Here we demonstrated that significantly increased capillary density and arteriolar density in the NPWT group at each specified time-point.
   Results: In the NPWT group, miR-126 expression was significantly increased on days 3, 5, 7, and 9 (P<0.05). Furthermore, statistically significant increases in VEGF mRNA and protein expression and p-ERK expression, as well as decreased SPRED1 expression, were noted upon treatment with NPWT on day 9. Our data revealed that miR-126 expression in the wound and plasma was significantly associated (P<0.05). Moreover, a positive correlation was also detected between increased levels of circulating miR-126 and arteriolar density, as well as capillary density (P<0.05).
   Conclusion: The study suggested that miR-126 was upregulated by NPWT and could represent a promising monitoring tool for angiogenesis in diabetic wounds treated with NPWT.
C1 [Zhang, Dong; Li, Zonghuan; Wang, Zheng; Zeng, Fanwei; Xiao, Weidong; Yu, Aixi] Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Xiao, WD; Yu, AX (通讯作者)，Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM 1539562641@qq.com; yuaixi@whu.edu.cn
RI Wang, Zheng/KLC-2372-2024; Zeng, Fanwei/LTY-9303-2024
OI Wang, Zheng/0000-0002-1176-7659; 
FU Independent Research Project of Wuhan University [2042017kf0079]
FX The authors would like to acknowledge the Wuhan VSD Medical Science &
   Technology, Co., Ltd. (Wuhan, China) for supplying the vacuum material.
   This work was supported by Grants from the Independent Research Project
   of Wuhan University (Grant no. 2042017kf0079).
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   Zou J, 2011, CIRC RES, V108, P201, DOI 10.1161/CIRCRESAHA.110.225045
NR 42
TC 26
Z9 31
U1 0
U2 18
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABETES METAB SYNDR
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 1685
EP 1696
DI 10.2147/DMSO.S199705
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IU3PU
UT WOS:000483499700001
PM 31564936
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kao, AM
   Cetrulo, LN
   Baimas-George, MR
   Prasad, T
   Heniford, BT
   Davis, BR
   Kasten, KR
AF Kao, Angela M.
   Cetrulo, Lawrence N.
   Baimas-George, Maria R.
   Prasad, Tanushree
   Heniford, Brant Todd
   Davis, Bradley R.
   Kasten, Kevin R.
TI Outcomes of open abdomen versus primary closure following emergent
   laparotomy for suspected secondary peritonitis: A propensity-matched
   analysis
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT Owen Wangensteen Scientific Forum / 104th Annual Clinical Congress and
   Scientific Forum of the American-College-of-Surgeons (ACS)
CY OCT 20-25, 2018
CL Boston, MA
SP Amer Coll Surg
DE Open abdomen; vacuum-assisted closure; on-demand laparotomy; emergency;
   peritonitis
ID DAMAGE-CONTROL; MANAGEMENT; COMPLICATIONS
AB BACKGROUND Optimal management following index laparotomy is poorly defined in secondary peritonitis patients. Although "open abdomen" (OA), or temporary abdominal closure with planned relaparotomy, is used to reassess bowel viability or severity of contamination, recent studies demonstrate comparable morbidity and mortality with primary abdominal closure (PC). This study evaluates differences between OA and PC following emergent laparotomy. METHODS Using the Premier database at a quaternary care center (2012-2016), nontrauma patients with secondary peritonitis requiring emergent laparotomy were identified (N = 534). Propensity matching for PC (n = 331; 62%) or OA (n = 203; 38%) was performed using variables: Mannheim Peritonitis Index, lactate, and vasopressor requirement. One hundred eleven closely matched pairs (PC:OA) were compared. RESULTS Five hundred thirty-four patients (55.0% female; mean age, 59.6 +/- 15.5 years) underwent emergent laparotomy. Of the OA patients, 136 (67.0%) had one relaparotomy, while 67 (33.0%) underwent multiple reoperations. Compared to daytime cases, laparotomies performed overnight (6 pm-6 am) had more temporary closures with OA (42.8% OA vs. 57.2% PC, p = 0.04). When assessing by surgeon type, PC was performed in 78.7% of laparotomies by surgical subspecialties compared to 56.7% (p < 0.0001) of acute care surgeons. After propensity matching, OA patients had increased postoperative complications (71.2% vs. 41.4%, p < 0.0001), mortality (22.5% vs. 11.7%, p = 0.006), and longer median length of stay (13 vs. 9 days, p = 0.0001). CONCLUSION Open abdomen was performed in 38.0% of patients, with one-third of those requiring multiple reoperations. Complications, mortality rates, and costs associated with OA were significantly increased when compared to PC. Given these findings, future studies are needed to determine appropriate indications for OA.
C1 [Kao, Angela M.; Cetrulo, Lawrence N.; Baimas-George, Maria R.; Prasad, Tanushree; Heniford, Brant Todd; Davis, Bradley R.; Kasten, Kevin R.] Carolinas Med Ctr, Dept Surg, Div Gastrointestinal & Minimally Invas Surg, Charlotte, NC 28203 USA.
C3 Carolinas Medical Center
RP Kasten, KR (通讯作者)，1025 Morehead Med Dr,Suite 300, Charlotte, NC 28203 USA.
EM kevin.kasten@atriumhealth.org
OI Baimas-George, Maria/0000-0002-6649-4627
CR Bleszynski MS, 2016, AM J SURG, V211, P926, DOI 10.1016/j.amjsurg.2016.01.012
   Coccolini F, 2017, WORLD J EMERG SURG, V12, P1, DOI DOI 10.1186/s13017-016-0112-3
   Coccolini F, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0029-2
   Diaz JJ, 2010, J TRAUMA, V68, P1425, DOI 10.1097/TA.0b013e3181da0da5
   Higa G, 2010, J TRAUMA, V69, P53, DOI 10.1097/TA.0b013e3181e293b4
   Holzheimer RG., 2001, Surgical Treatment: Evidence-Based and Problem- Oriented
   Kirkpatrick AW, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0183-4
   Kreis BE, 2013, MED SCI MONITOR, V19, pS24
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   Schein M, 2002, LANGENBECK ARCH SURG, V387, P1, DOI 10.1007/s00423-002-0276-z
   van Ruler O, 2007, JAMA-J AM MED ASSOC, V298, P865, DOI 10.1001/jama.298.8.865
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NR 22
TC 29
Z9 33
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD SEP
PY 2019
VL 87
IS 3
BP 623
EP 629
DI 10.1097/TA.0000000000002345
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Surgery
GA IU8KC
UT WOS:000483829500021
PM 31045736
DA 2026-07-24
ER
PT J
AU Wee, IJY
   Syn, N
   Choong, AMTL
AF Wee, Ian J. Y.
   Syn, Nicholas
   Choong, Andrew M. T. L.
TI Closed Incision Negative Pressure Wound Therapy in Vascular Surgery: A
   Systematic Review and Meta-Analysis
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE Closed incision negative pressure wound therapy; Vascular surgery;
   Surgical site infections
ID SURGICAL SITE INFECTION; ARTERIAL RECONSTRUCTION; COMPLICATIONS;
   PREVENTION; PATIENT
AB Background: Closed incision negative pressure wound therapy (CiNPT) may be a valuable treatment option for surgical site infections. This systematic review and meta-analysis sought to compare CiNPT against conventional wound care after vascular procedures.
   Methods: This study conformed to the PRISMA guidelines. An electronic search was performed on Medline/Pubmed, EMBASE, and the Cochrane Library. The date of last search was July 11 2018. Relative risks and mean differences for primary and secondary outcomes were calculated. A random effects model was used for substantial heterogeneity (I-2 > 30%). The Cochrane Risk of Bias tool was employed to rate the methodological quality of the included studies, whilst the GRADE approach was use to grade the level of evidence for the observed effects.
   Results: Of 47 studies, five randomised controlled trials (RCTs) were included, comprising 662 patients, of which 47.9% underwent CiNPT and 52.1% received conventional care. The overall risk of infection (RR = 0.31, 95% CI 0.21-0.47) (high quality), Szilagyi Grades I (RR = 0.35, 95% CI 0.20-0.60) (high quality), and III (RR = 0.17, 95% CI 0.04-0.68) (high quality) infections, need for antibiotics (RR = 0.36, 95% CI 0.20-.64) (high quality), and surgical re-intervention (RR = 0.27, 95% CI 0.27-0.98) (high quality) were lower in the CiNPT group. However, there were no significant differences in the risk of Grade II (RR = 0.59, 95% CI 0.10-3.66) (moderate quality), as well as length of hospital stay (mean difference, MD = -0.59, 95% CI -2.48 to 1.31) (moderate quality), and 30 day mortality (RR = 3.95, 95% CI 0.17-94.76) (high quality).
   Conclusion: While there is evidence demonstrating that CiNPT reduces the risk of Grades I and III infections and re-interventions, there was a noticeable lack of difference in other important post-operative outcomes. Further well designed RCTs are needed to corroborate these findings.
C1 [Wee, Ian J. Y.; Syn, Nicholas; Choong, Andrew M. T. L.] SingVaSC, Singapore Vasc Surg Collaborat, Singapore, Singapore.
   [Wee, Ian J. Y.] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Choong, Andrew M. T. L.] Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.
   [Choong, Andrew M. T. L.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore, Singapore.
   [Choong, Andrew M. T. L.] Natl Univ Heart Ctr, Div Vasc Surg, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; National University of Singapore
RP Choong, AMTL (通讯作者)，Natl Univ Heart Ctr, Dept Cardiac Thorac & Vasc Surg, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore.
EM suramctl@nus.edu.sg
RI Syn, Nicholas/A-3770-2017; Choong, Andrew/B-7168-2013
OI Syn, Nicholas/0000-0002-6343-176X; Choong, Andrew/0000-0002-7171-4516
CR [Anonymous], 2009, BMJ-BRIT MED J, V21, P7, DOI [DOI 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, DOI 10.7326/0003-4819-151-4-200908180-00135]
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   Giovannacci L, 2002, EUR J VASC ENDOVASC, V24, P196, DOI 10.1053/ejvs.2002.1667
   Gombert A, 2018, EUR J VASC ENDOVASC, V56, P442, DOI 10.1016/j.ejvs.2018.05.018
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   Kwon J, 2018, J VASC SURG, V68, P1744, DOI 10.1016/j.jvs.2018.05.224
   Lee K, 2017, J VASC SURG, V66, P1814, DOI 10.1016/j.jvs.2017.06.084
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   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
NR 24
TC 21
Z9 22
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD SEP
PY 2019
VL 58
IS 3
BP 446
EP 454
DI 10.1016/j.ejvs.2018.12.021
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA IV1AT
UT WOS:000484010400031
PM 31378658
OA Bronze
DA 2026-07-24
ER
PT J
AU Dyck, BA
   Bailey, CS
   Steyn, C
   Petrakis, J
   Urquhart, JC
   Raj, R
   Rasoulinejad, P
AF Dyck, Bailey A.
   Bailey, Christopher S.
   Steyn, Chris
   Petrakis, Julia
   Urquhart, Jennifer C.
   Raj, Ruheksh
   Rasoulinejad, Parham
TI Use of incisional vacuum-assisted closure in the prevention of
   postoperative infection in high-risk patients who underwent spine
   surgery: a proof-of-concept study
SO JOURNAL OF NEUROSURGERY-SPINE
LA English
DT Article
DE negative-pressure wound therapy; surgical site infection; open posterior
   spine surgery; vacuum-assisted closure
ID PRESSURE WOUND THERAPY; SURGICAL SITE INFECTION; VANCOMYCIN POWDER;
   COMPLICATIONS
AB OBJECTIVE This proof-of-concept study was conducted to determine whether negative-pressure wound therapy, through the use of incisional vacuum-assisted closure (VAC), is associated with a reduction in surgical site infections (SSIs) when compared to standard wound dressings in patients undergoing open posterior spinal fusion who have a high risk of infection.
   METHODS A total of 64 patients were examined; 21 patients received incisional VAC application (VAC group) versus 43 diagnosis-matched patients who received standard wound dressings (control group). Patients in the VAC group were prospectively enrolled in a consecutive series between March 2013 and March 2014 if they met the following diagnostic criteria for high risk of infection: posterior open surgery across the cervicothoracic junction; thoracic kyphosis due to metastatic disease; high-energy trauma; or multilevel revision reconstructive surgery. Patients in the VAC group also met one or more comorbidity criteria, including body mass index >= 35 or < 18.5, diabetes, previous radiation at surgical site, chemotherapy, steroid use, bedridden state, large traumatic soft-tissue disruption, or immunocompromised state. Consecutive patients in the control group were retrospectively selected from the previous year by the same high-risk infection diagnostic criteria as the VAC group. All surgeries were conducted by the same surgeon at a single site. The primary outcome was SSI. All patients had 1 year of follow-up after their surgery. Baseline demographics, intraoperative parameters, and postoperative wound infection rates were compared between groups.
   RESULTS Patient demographics including underlying comorbidities were similar, with the exception that VAC-treated patients were malnourished (p = 0.020). VAC-treated patients underwent longer surgeries (p < 0.001) and required more postoperative ICU admissions (p = 0.039). The median length of hospital stay was not different between groups. In total, 9 control patients (21%) developed an SSI, versus 2 VAC-treated patients (10%).
   CONCLUSIONS Patients in this cohort were selected to have an increased risk of infection; accordingly, the rate of SSI was high. However, negative-pressure wound therapy through VAC application to the postoperative incision resulted in a 50% reduction in SSI. No adverse effects were noted secondary to VAC application. The preliminary data confirm the authors' proof of concept and strongly support the need for a prospective randomized trial.
C1 [Dyck, Bailey A.; Bailey, Christopher S.; Steyn, Chris; Petrakis, Julia; Urquhart, Jennifer C.; Raj, Ruheksh; Rasoulinejad, Parham] Univ Western Ontario, Combined Orthopaed & Neurosurg Spine Program, London Hlth Sci Ctr, London, ON, Canada.
   [Bailey, Christopher S.; Urquhart, Jennifer C.; Raj, Ruheksh; Rasoulinejad, Parham] Univ Western Ontario, Lawson Hlth Res Inst, London, ON, Canada.
   [Dyck, Bailey A.; Bailey, Christopher S.; Steyn, Chris; Rasoulinejad, Parham] Univ Western Ontario, Schulich Sch Med & Dent, Dept Surg, London, ON, Canada.
   [Petrakis, Julia] Univ Western Ontario, Arthur Labatt Sch Nursing, London, ON, Canada.
C3 London Health Sciences Centre; Western University (University of Western
   Ontario); Western University (University of Western Ontario); University
   Western Ontario Hospital; Western University (University of Western
   Ontario); Western University (University of Western Ontario)
RP Dyck, BA (通讯作者)，Univ Western Ontario, London Hlth Sci Ctr, London, ON, Canada.
EM chris.bailey@lhsc.on.ca
RI Bailey, Christopher/L-7522-2015; Urquhart, Jennifer/Q-7604-2016;
   Rasoulinejad, Parham/G-3294-2019
OI Bailey, Christopher/0000-0001-5508-8415; 
CR Altintas B, 2015, INT WOUND J, V12, P662, DOI 10.1111/iwj.12198
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   Chahoud J, 2014, FRONT MED-LAUSANNE, V1, DOI 10.3389/fmed.2014.00007
   Gillespie BM, 2015, SURG INNOV, V22, P488, DOI 10.1177/1553350615573583
   Hansen E, 2013, CLIN ORTHOP RELAT R, V471, P3230, DOI 10.1007/s11999-013-2937-3
   Horan TC, 2008, AM J INFECT CONTROL, V36, P309, DOI 10.1016/j.ajic.2008.03.002
   Horch RE, 2015, J WOUND CARE, V24, P21, DOI 10.12968/jowc.2015.24.Sup4b.21
   Mark KS, 2014, SURG INNOV, V21, P345, DOI 10.1177/1553350613503736
   Martin JR, 2014, SPINE, V39, P177, DOI 10.1097/BRS.0000000000000071
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   Ousey KJ, 2013, SPINE J, V13, P1393, DOI 10.1016/j.spinee.2013.06.040
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   Parchi PD, 2015, ORTHOP REV, V7, P63, DOI 10.4081/or.2015.5900
   Reddix Robert N Jr, 2009, Am J Orthop (Belle Mead NJ), V38, P446
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   Van Hal M, 2017, CLIN SPINE SURG, V30, pE1062, DOI 10.1097/BSD.0000000000000516
   Veeravagu A, 2009, SPINE, V34, P1869, DOI 10.1097/BRS.0b013e3181adc989
NR 19
TC 40
Z9 43
U1 0
U2 9
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1547-5654
EI 1547-5646
J9 J NEUROSURG-SPINE
JI J. Neurosurg.-Spine
PD SEP
PY 2019
VL 31
IS 3
BP 430
EP 439
DI 10.3171/2019.2.SPINE18947
PG 10
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA IV1LB
UT WOS:000484037600017
PM 31075767
DA 2026-07-24
ER
PT J
AU Perry, TL
   Kranker, LM
   Mobley, EE
   Curry, EE
   Johnson, RM
AF Perry, Travis L.
   Kranker, Lindsay M.
   Mobley, Erin E.
   Curry, Eileen E.
   Johnson, R. Michael
TI Outcomes in Fournier's Gangrene Using Skin and Soft Tissue Sparing Flap
   Preservation Surgery for Wound Closure: An Alternative Approach to Wide
   Radical Debridement
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE Fournier's gangrene; necrotizing fasciitis; necrotizing soft tissue
   infection; complete necrosectomy; negative pressure wound therapy;
   centrifugal and vertical infection transmission; surgical; infection
ID VACUUM-ASSISTED CLOSURE; NECROTIZING FASCIITIS; SEVERITY INDEX;
   INFECTIONS; MANAGEMENT; PREDICTION; VALIDATION; EXPERIENCE; MORTALITY;
   THERAPY
AB Introduction. Fournier's gangrene (FG) remains a forbidding necrotizing soft tissue infection (NSTI) that necessitates early recognition, prompt surgical excision, and goal-directed antibiotic therapy. Traditionally, surgical management has included wide radical excision for sepsis control, but this management often leaves large, morbid wounds that require complex wound coverage, prolonged hospitalizations, and/or delayed healing. Objective. The purpose of this case series is to report the outcomes of FG using a surrogate approach of concurrent debridement of spared skin and soft tissue, negative pressure wound therapy (NPWT), and serial delayed primary closure (DPC). Materials and Methods. A retrospective review of 17 consecutive patients with FG treated with concurrent skin and soft tissue sparing surgery, NPWT, and serial DPC at Miami Valley Hospital Regional Adult Burn and Wound Center (Dayton, OH) between 2008 and 2018 was conducted. Patients were included if the following were noted: clinical suspicion of FG based on genital and perinea! cellulitis, fever, leukocytosis, and confirmation of tissue necrosis upon surgical exploration. Patients not treated with skin sparing surgical debridement or wounds with an inability to maintain a NPWT dressing seal were excluded. Results. The mean number of total surgeries including simultaneous debridement and reconstruction was 5.5. The average intensive care unit and hospital length of stay was 3.2 and 18.9 days, respectively. The average number of days from initial consult to wound closure was 24.3. The need for colostomy and skin grafts were nearly eliminated with this surrogate approach. Using this reproducible technique, DPC was achieved in 100% of patients. Only 11.8% (2/17) required split-thickness skin grafting as part of wound closure. The majority (9/17; 52.9%) were partially managed as an outpatient during wound closure. During staged DPC, the mean number of outpatient management days was 16.0. There were no mortalities in this series of patients. Conclusions. To the best of the authors' knowledge, this is the largest case series reported in the literature using skin and soft tissue sparing surgery for wound closure of a FG NSTI.
C1 [Perry, Travis L.; Mobley, Erin E.] Miami Valley Hosp Reg Adult Burn & Wound Ctr, Dayton, OH USA.
   [Perry, Travis L.; Kranker, Lindsay M.] Wright State Univ, Boonshoft Sch Med, Dept Surg, Dayton, OH 45409 USA.
   [Curry, Eileen E.; Johnson, R. Michael] Wright State Univ, Boonshoft Sch Med, Div Plast Surg, Dayton, OH 45409 USA.
C3 University System of Ohio; Wright State University Dayton; University
   System of Ohio; Wright State University Dayton
RP Perry, TL (通讯作者)，Wright State Univ, Miami Valley Hosp, Boonshoft Sch Med, Dept Surg, One Wyoming St,Suite 3271, Dayton, OH 45409 USA.
EM tlperry@premierhealth.com
RI Kranker, Lindsay M/AAZ-7139-2020
OI Kranker, Lindsay M/0000-0002-0372-929X
CR [Anonymous], 2014, CURR PROB SURG, V51, P344, DOI 10.1067/j.cpsurg.2014.06.001
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   Tom LK, 2016, J AM COLL SURGEONS, V222, pE47, DOI 10.1016/j.jamcollsurg.2016.01.008
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   Wong Chin-Ho, 2008, Am J Surg, V196, pe19, DOI 10.1016/j.amjsurg.2007.08.076
NR 38
TC 18
Z9 20
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2018
VL 30
IS 10
BP 290
EP +
PG 16
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV1TW
UT WOS:000484062600005
PM 30299266
DA 2026-07-24
ER
PT J
AU Muresan, M
   Muresan, S
   Brinzaniuc, K
   Sala, D
   Neagoe, R
AF Muresan, Mircea
   Muresan, Simona
   Brinzaniuc, Klara
   Sala, Daniela
   Neagoe, Radu
TI Negative Pressure Wound Therapy of Open Abdomen and Definitive Closure
   Techniques After Decompressive Laparotomy: A Single-center Observational
   Prospective Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE open abdomen; negative pressure wound therapy; abdominal compartment
   syndromey
ID ABDOMINAL COMPARTMENT SYNDROME; TEMPORARY CLOSURE; MANAGEMENT; MESH;
   EXPERIENCE
AB Introduction. Open abdomen is a concept that was developed especially in relation to abdominal compartment syndrome (ACS). Objective. This study presents the evolution and complications related to the management of the open abdomen after decompressive laparotomy, using a standardized method based on negative pressure wound therapy (NPWT). Materials and Methods. This observational prospective study conducted over a 9-month period included 19 patients who underwent decompressive laparotomies for ACS. The triggering conditions were peritonitis, infected and noninfected acute pancreatitis, ileus, and trauma. Temporary abdominal closure was performed using NPWT and the final closure by primary suture or dual mesh. Intra-abdominal pressure was permanently and indirectly monitored transvesically. Results. After decompressive laparotomy, the intra-abdominal pressure decreased significantly (P < .001) compared with the value preoperatively (41.4 mm Hg to 15.3 mm Hg). Mortality was 21.2%, with higher rates for acute pancreatitis (odds ratio [OR] = 3.75) and trauma (OR = 1.25) due to the severity of the primary illness. The final closure was performed after 11.7 days, and primary closure was possible in 4 cases. Conclusions. Decompressive laparotomy significantly reduced intra-abdominal pressure for ACS, improving the prognosis.
C1 [Muresan, Mircea; Muresan, Simona; Brinzaniuc, Klara; Sala, Daniela; Neagoe, Radu] Univ Med & Pharm Tirgu Mures, Targu Mures, Romania.
C3 George Emil Palade University of Medicine, Pharmacy, Science, &
   Technology of Targu Mures
RP Muresan, S (通讯作者)，Univ Med & Pharm Tirgu Mures, Physiol, CR Vivu, D9-19, Targu Mures 540109, Mures, Romania.
EM dr_muremir@yahoo.com
RI Neagoe, Radu Mircea/AAE-6364-2022; Muresan, Mircea/LXV-0408-2024;
   Muresan, Simona/KIG-8771-2024; Sala, Daniela Tatiana/IAM-2498-2023
OI Neagoe, Radu Mircea/0009-0006-0712-6070; Muresan,
   Mircea/0000-0002-5262-8524; 
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
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NR 35
TC 4
Z9 4
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2018
VL 30
IS 10
BP 310
EP +
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV1TW
UT WOS:000484062600008
PM 30212374
DA 2026-07-24
ER
PT J
AU Huang, Q
   Wang, JT
   Gu, HC
   Cao, G
   Cao, JC
AF Huang, Qiang
   Wang, Ji-Ting
   Gu, Han-Cheng
   Cao, Gang
   Cao, Jian-Chun
TI Comparison of Vacuum Sealing Drainage and Traditional Therapy for
   Treatment of Diabetic Foot Ulcers: A Meta-Analysis
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE complication; diabetic foot ulcers; efficacy; vacuum sealing drainage
ID PRESSURE WOUND THERAPY; ASSISTED CLOSURE; COMPRESSION THERAPY;
   RANDOMIZED-TRIAL; MANAGEMENT; STANDARD; MULTICENTER; EXPERIENCE; PEOPLE;
   CARE
AB Vacuum sealing drainage (VSD) is a noninvasive adjunctive therapy to help patients with diabetic foot ulcers by reducing edema and promoting wound healing and formation of granulation tissue. Multiple databases were searched for relevant studies, and full-text articles comparing VSD and conventional therapy were reviewed. Meta-analyses were conducted with Review Manager 5.0 software to estimate the results of the selected articles. Forest plots, sensitivity analysis, and bias analysis were also performed on the included articles. In total, 10 studies satisfied the inclusion criteria and were selected in this study. The meta-analysis suggested that the duration of therapy, decrease of wound size, and efficacy rate showed statistically significant differences between the 2 groups (mean difference = -12.86; 95% confidence interval [CI] -12.86 to -8.52; p < .00001; mean difference = 8.71; 95% CI 3.25 to 14.17; p= .002; relative risk = 1.41; 95% CI 1.22 to 1.62; p < .00001, respectively) although the complication rate between the 2 groups was comparable (relative risk = 0.83; 95% CI 0.60 to 1.16; p = .28). Publication bias was not assessed because only a few articles were included. In conclusion, VSD is a more effective therapy and is associated with a greater decrease in wound size and shorter time to wound healing, compared to the conventional method. (C) 2018 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Huang, Qiang; Wang, Ji-Ting; Gu, Han-Cheng; Cao, Gang; Cao, Jian-Chun] Beijing Univ Chinese Med, Dong Fang Hosp, Dept Surg 4, 6 First Dist Fang Xing Yuan, Beijing 100078, Peoples R China.
C3 Beijing University of Chinese Medicine
RP Cao, JC (通讯作者)，Beijing Univ Chinese Med, Dong Fang Hosp, Dept Surg 4, 6 First Dist Fang Xing Yuan, Beijing 100078, Peoples R China.
EM caojianchun02@163.com
CR Ahmed AM, 2002, SAUDI MED J, V23, P373
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   [朱新华 Zhu Xinhua], 2014, [中国组织工程研究, Chinese Journal of Tissue Engineering Research], V18, P5548
NR 41
TC 24
Z9 32
U1 2
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD SEP
PY 2019
VL 58
IS 5
BP 954
EP 958
DI 10.1053/j.jfas.2018.12.020
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA IV1UU
UT WOS:000484065100024
PM 31474407
DA 2026-07-24
ER
PT J
AU Smud-Orehovec, S
   Mance, M
   Haluzan, D
   Vrbanovic-Mijatovic, V
   Mijatovic, D
AF Smud-Orehovec, Sanda
   Mance, Marko
   Haluzan, Damir
   Vrbanovic-Mijatovic, Vilena
   Mijatovic, Davor
TI Defect Reconstruction of an Infected Diabetic Foot Using Split- and
   Full-thickness Skin Grafts With Adjuvant Negative Pressure Wound
   Therapy: A Case Report and Review of the Literature
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE Charcot foot; full-thickness skin graft; negative pressure wound
   therapy; split-thickness skin graft; diabetic foot; infection; foot
   reconstruction
ID IN-VITRO; ANTIMICROBIAL EFFICACY; ULCERS; RESISTANCE; BIOFILMS;
   BACTERIA; COLONIZATION; DRESSINGS; SILVER
AB Introduction. Any alteration or impairment to normal wound healing can result in the development of chronic wounds, which may lead to serious complications such as infection and loss of body fluid and proteins. Primary closure alone may not be sufficient to fulfill the criteria of successful defect reconstruction. Therefore, additional procedures such as skin grafting must be considered as an option. Case Report. The case of a 43-year-old woman with diabetes who was admitted to the University Hospital Rebro (Zagreb, Croatia) due to an infected, nonhealing wound on her left foot. Skin grafts combined with negative pressure wound therapy (NPWT) before and after graft application improved wound healing in this patient. Conclusions. In this patient, the combination of skin grafts with NPWT before and after graft application reduced the comorbidities and complications often seen in the diabetic patient population. Herein, the authors utilized a quicker, cost-efficient, and safer technique of wound closure compared with traditional nonsurgical methods.
C1 [Smud-Orehovec, Sanda; Mance, Marko; Mijatovic, Davor] Univ Hosp Rebro, Dept Plast Reconstruct & Aesthet Surg, Kispaticeva 12, Zagreb, Croatia.
   [Haluzan, Damir] Univ Hosp Rebro, Dept Vasc Surg, Zagreb, Croatia.
   [Vrbanovic-Mijatovic, Vilena] Univ Hosp Rebro, Dept Anesthesiol & ICU, Zagreb, Croatia.
RP Mance, M (通讯作者)，Univ Hosp Rebro, Dept Plast Reconstruct & Aesthet Surg, Kispaticeva 12, Zagreb, Croatia.
EM markomance@gmail.com
OI Vrbanović Mijatović, Vilena/0000-0001-8568-1359
CR Aerden D, 2013, J WOUND CARE, V22, P85, DOI 10.12968/jowc.2013.22.2.85
   Aguiree, 2013, Resources | IDF Diabetes Atlas', V6th
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NR 61
TC 7
Z9 8
U1 0
U2 9
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2018
VL 30
IS 11
BP E108
EP E115
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV1VC
UT WOS:000484065900003
PM 30457564
DA 2026-07-24
ER
PT J
AU Ikeno, Y
   Sakakibara, S
   Yokawa, K
   Kitani, K
   Nakai, H
   Yamanaka, K
   Inoue, T
   Tanaka, H
   Terashi, H
   Okita, Y
AF Ikeno, Yuki
   Sakakibara, Shunsuke
   Yokawa, Koki
   Kitani, Keitaro
   Nakai, Hidekazu
   Yamanaka, Katsuhiro
   Inoue, Takeshi
   Tanaka, Hiroshi
   Terashi, Hiroto
   Okita, Yutaka
TI Post-sternotomy deep wound infection following aortic surgery: wound
   care strategies to prevent prosthetic graft replacement
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Deep sternal wound infection; Perioperative care (intraoperative care);
   Surgery; Complications; Negative pressure wound therapy; Continuous
   irrigation
ID VACUUM-ASSISTED CLOSURE; OMENTAL FLAP TRANSPOSITION; SURGICAL STRATEGY;
   RECONSTRUCTION; MEDIASTINITIS; IRRIGATION; COMPLICATIONS; MORTALITY;
   SURVIVAL
AB OBJECTIVES: The aim of this study was to evaluate the early and long-term outcomes of our multidisciplinary strategy for treating deep sternal wound infection after aortic grafting, which consisted of debridement by a plastic surgeon, negative pressure wound therapy with continuous irrigation and chest wall reconstruction.
   METHODS: We performed a retrospective analysis of 18 patients who had a deep sternal wound infection following aortic grafting through a median sternotomy between January 2009 and December 2017. All patients had organisms cultured from mediastinal tissue within 2 months from the initial aortic surgery. The prosthetic grafts were exposed in 15 patients during resternotomy. Our protocol involved repeat debridement and negative pressure wound therapy with continuous irrigation twice a week until the results of the culture were negative and chest wall reconstruction was complete.
   RESULTS: The mean duration from primary aortic surgery to resternotomy was 23.7 +/- 15.9 days. Except for 1 patient, 17 patients underwent chest wall reconstruction. The mean duration from resternotomy to chest wall reconstruction was 31.1 +/- 28.0 days. The hospital mortality rate was 16.7% (3 patients), although no patients died of wound-related causes. The mean follow-up period was 2.9 +/- 2.5 years. Overall survival was 69.6 +/- 11.4% at 1 year and 54.2 +/- 13.3% at 5 years. Freedom from reoperation for reinfection was 94.4 +/- 5.4% at 5 years.
   CONCLUSIONS: Our wound care strategy achieved acceptable early and late survival in patients who had deep sternal wound infection following aortic grafting. This strategy may benefit those who experience this devastating complication.
C1 [Ikeno, Yuki; Yokawa, Koki; Nakai, Hidekazu; Yamanaka, Katsuhiro; Inoue, Takeshi; Tanaka, Hiroshi; Okita, Yutaka] Kobe Univ, Grad Sch Med, Dept Cardiovasc Surg, Kobe, Hyogo, Japan.
   [Sakakibara, Shunsuke; Kitani, Keitaro; Terashi, Hiroto] Kobe Univ, Grad Sch Med, Dept Plast Surg, Kobe, Hyogo, Japan.
C3 Kobe University; Kobe University
RP Okita, Y (通讯作者)，Kobe Univ, Grad Sch Med, Dept Surg, Div Cardiovasc Surg,Chuo Ku, 7-5-2 Kusunoki Cho, Kobe, Hyogo 6500017, Japan.
EM yutakaokita@gmail.com
RI Sakakibara, Shunsuke/JWP-3331-2024; Yokawa, Koki/OUJ-3462-2025
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NR 28
TC 10
Z9 12
U1 0
U2 9
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD MAY
PY 2019
VL 55
IS 5
BP 975
EP 982
DI 10.1093/ejcts/ezy389
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA IV2DK
UT WOS:000484087700026
PM 30544183
OA Bronze
DA 2026-07-24
ER
PT J
AU Raizman, R
AF Raizman, Rose
TI Fluorescence imaging guided dressing change frequency during negative
   pressure wound therapy: a case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE bacterial fluorescence imaging; MolecuLight; negative pressure wound
   therapy; wound infection; wounds
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; BACTERIAL LOAD; MANAGEMENT;
   BIOBURDEN; DEVICE
AB Objective: Knowledge of wound bioburden can guide selection of therapies, for example, the use of negative pressure wound therapy (NPWT) devices with instillation in a heavily contaminated wound. Wound and periwound bacteria can be visualised in real-time using a novel, non-contact, handheld fluorescence imaging device that emits a safe violet light. This device was used to monitor bacterial burden in patients undergoing NPWT.
   Methods: Diverse wounds undergoing NPWT were imaged for bacterial (red or cyan) fluorescence as part of routine wound assessments.
   Results: We assessed 11 wounds undergoing NPWT. Bacterial fluorescence was detected under sealed, optically-transparent (routine) adhesive before dressing changes, on foam dressings, within the wound bed, and on periwound tissues. Bacterial visualisation in real-time helped to guide: (1) bioburden-based, personalised treatment regimens, (2) clinician selection of NPWT, with or without instillation of wound cleansers, and (3) the extent and location of wound cleaning during dressing changes. The ability to visualise bacteria before removal of dressings led to expedited dressing changes when heavy bioburden was detected and postponement of dressing changes for 24 hours when red fluorescence was not observed, avoiding unnecessary disturbance of the wound bed.
   Conclusion: Fluorescence imaging of bacteria prompted and helped guide the timing of dressing changes, the extent of wound cleaning, and selection of the appropriate and most cost-effective NPWT (standard versus instillation). These results highlight the capability of bacterial fluorescence imaging to provide invaluable real-time information on a wound's bioburden, contributing to clinician treatment decisions in cases where bacterial contamination could impede wound healing.
C1 [Raizman, Rose] Univ Toronto, Lawrence S Bloomberg Fac Nursing, Toronto, ON, Canada.
   [Raizman, Rose] Scarborough Hlth Network, Dept Profess Practice, Scarborough, ON, Canada.
C3 University of Toronto
RP Raizman, R (通讯作者)，Univ Toronto, Lawrence S Bloomberg Fac Nursing, Toronto, ON, Canada.; Raizman, R (通讯作者)，Scarborough Hlth Network, Dept Profess Practice, Scarborough, ON, Canada.
EM rraizman@shn.ca
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NR 36
TC 19
Z9 19
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2019
VL 28
IS 9
SU S
BP S28
EP S37
DI 10.12968/jowc.2019.28.Sup9.S28
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IV4QI
UT WOS:000484257200004
PM 31509488
DA 2026-07-24
ER
PT J
AU Obst, MA
   Harrigan, J
   Wodash, A
   Bjurstrom, S
AF Obst, Mary Anne
   Harrigan, Jane
   Wodash, Aaron
   Bjurstrom, Stina
TI Early-stage Management of Complex Wounds Using Negative Pressure Wound
   Therapy With Instillation and a Dressing With Through Holes
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE Negative pressure wound therapy; instillation; wound management;
   NPWTi-d; open-cell foam dressing; dressings; complex wound; chronic
   wound; necrotizing fasciitis
ID SALINE
AB Introduction. An early-stage decision clinicians often make in the management of complex wounds is which method of wound preparation will be appropriate for the patient. This decision can be affected by numerous wound and patient risk factors that present challenges and may make surgical debridement difficult in patients with complex wounds. Recently, negative pressure wound therapy with instillation and dwell time (NPWTi-d) using a novel reticulated open-cell foam dressing with through holes (ROCF-CC) was shown to aid in the loosening and removal of thick exudate and nonviable tissue from wounds. Objective. The authors present their experiences of using NPWTi-d with ROCF-CC, along with rationales for wound care decisions. Materials and Methods. Patients received antibiotics and surgical debridement when appropriate. Therapy selection and parameters were based on a decision-tree model for wound care management that takes into consideration patient and wound information. Most patients received NPWTi-d with ROCF-CC for a duration of 5 to 8 days; however, 1 patient received NPWTi-d with ROCF-CC for more than 30 days due to the wound extent and severity. Therapy consisted of instilling saline or quarter-strength sodium hypochlorite solution with dwell times of 3 to 10 minutes, followed by 2 hours or 3.5 hours of NPWT either at -100 mm Hg or -125 mm Hg. Results. There were 6 patients (3 men, 3 women; average age, 58.5 years) treated. Wound types included 3 pressure ulcers, 1 necrotizing soft tissue infection, 1 perianal abscess, and 1 large abdominal wound. Patient comorbidities included obesity, type 2 diabetes, and radiation therapy. In all cases, progression of wound healing was observed with no complications. This method produced viable granulation tissue and wound bed preparation; however, patients were not followed to closure or grafting. Conclusions. These cases help support the use of NPWTi-d with ROCF-CC as a viable option for wound care providers in the early-stage management of complex
C1 [Obst, Mary Anne] Reg Hosp, Complex Abdominal Reconstruct Serv, 640 Jackson St, St Paul, MN 55101 USA.
   [Harrigan, Jane; Bjurstrom, Stina] Reg Hosp, Wound & Ostomy Serv, St Paul, MN USA.
   [Wodash, Aaron] Reg Hosp, Orthoped, St Paul, MN USA.
RP Obst, MA (通讯作者)，Reg Hosp, Complex Abdominal Reconstruct Serv, 640 Jackson St, St Paul, MN 55101 USA.
EM maryanneobst@gmail.com
CR Blome-Eberwein S, 2018, Burns Open, V2, P208, DOI [10.1016/j.burnso.2018.05.004, 10.1016/j.burnso.2018.05.004, DOI 10.1016/J.BURNSO.2018.05.004]
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NR 11
TC 9
Z9 11
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2019
VL 31
IS 5
BP E33
EP E36
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV4YS
UT WOS:000484279000003
PM 31184590
DA 2026-07-24
ER
PT J
AU Mari, W
   Younes, S
   Naqvi, J
   Abu Issa, A
   Oroszi, TL
   Cool, DR
   Travers, JB
   Simman, R
AF Mari, Walid
   Younes, Sara
   Naqvi, Jaree
   Abu Issa, Abdelfattah
   Oroszi, Terry L.
   Cool, David R.
   Travers, Jeffrey B.
   Simman, Richard
TI Use of a Natural Porcine Extracellular Matrix With Negative Pressure
   Wound Therapy Hastens the Healing Rate in Stage 4 Pressure Ulcers
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE chronic wound; Oasis Ultra; extracellular matrix; dressing; biological
   wound matrices; pressure ulcer; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE
AB Introduction. Chronic wounds are physically debilitating and painful and are responsible for the addition of more than $25 billion annually in health care costs in the United States. Extracellular matrix (ECM) replacements have been demonstrated to aid in wound healing by providing an optimal environment to facilitate the healing process. Objective. This study examines the healing rates of stage 4 pressure ulcers using combination of a commercially available porcine-based wound matrix dressing alongside negative pressure wound therapy (NPWT) versus using NPWT alone. Materials and Methods. Patients were randomized to receive either the matrix plus NPWT (study) or NPWT alone (control) for stage 4 sacral pressure ulcer treatment. Wounds were photographed and measured weekly. The experimental group had their ECM dressings changed every other week and their NPWT changed twice weekly. Results. A total of 16 patients, 8 study and 8 control, completed this study. After the 12-week study period, the average control patient healing rate was 45.79% as compared with the 89.98% healing rate in the study group (P<.01). The difference in healing rate between control and study patients was optimal by 12 weeks. Conclusions. These studies suggest that ECM dressings may be a promising adjunctive treatment option for stage 4 pressure ulcers.
C1 [Mari, Walid; Younes, Sara; Naqvi, Jaree; Abu Issa, Abdelfattah; Oroszi, Terry L.; Cool, David R.; Travers, Jeffrey B.; Simman, Richard] Wright State Univ, Dept Pharmacol & Toxicol, Boonshoft Sch Med, Dayton, OH 45435 USA.
C3 University System of Ohio; Wright State University Dayton
RP Simman, R (通讯作者)，ProMedica Toledo Hosp, Jobst Vasc Inst, 2109 Hughes Dr,Suite 400, Toledo, OH 43606 USA.
EM richard.simmanmd@promedica.org
RI Travers, Jeffrey/KLE-3517-2024
OI Travers, Jeffrey/0000-0001-7232-1039
CR AbouIssa A, 2015, WOUNDS, V27, P313
   [Anonymous], 2016, NPUAP Pressure Injury Stages
   Black Joyce, 2007, Adv Skin Wound Care, V20, P269, DOI 10.1097/01.ASW.0000269314.23015.e9
   Das S, 2016, FRONT BIOENG BIOTECH, V4, DOI 10.3389/fbioe.2016.00082
   Das S, 2016, ACTA BIOMATER, V42, P56, DOI 10.1016/j.actbio.2016.07.001
   Di Lullo GA, 2002, J BIOL CHEM, V277, P4223, DOI 10.1074/jbc.M110709200
   Flanagan M, 2000, J Wound Care, V9, P299
   Fleck C.A., 2010, J AM COLL CERTIFIED, V2, P50, DOI DOI 10.1016/J.JCWS.2010.12.003
   Frade MAC., 2013, Ulcers, V2013, DOI [10.1155/2013/964826, DOI 10.1155/2013/964826]
   Gillitzer R, 1998, CHEMOKINES SKIN, P119
   Hodde JP, 2015, J WOUND CARE, V14, P23
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Turner NJ, 2015, ADV WOUND CARE, V4, P490, DOI 10.1089/wound.2014.0604
NR 15
TC 17
Z9 21
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2019
VL 31
IS 5
BP 117
EP 122
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV4YS
UT WOS:000484279000006
PM 30990777
DA 2026-07-24
ER
PT J
AU Griffin, L
   Sifuentes, MM
AF Griffin, Leah
   Sifuentes, Mikaela M.
TI Retrospective Payor Claims Analysis of Patients Receiving Outpatient
   Negative Pressure Wound Therapy With Remote Therapy Monitoring
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; telemedicine; remote consultation; cost
   savings; patient compliance; outpatients; wound healing
ID ADHERENCE
AB Introduction. Patient nonadherence to home care treatment poses an obstacle to wound healing that can lead to additional costs and prolong care. Objective. This retrospective pilot study examines the potential time and cost savings associated with a remote therapy monitoring (RTM) program designed to improve negative pressure wound therapy (NPWT) adherence in the home care setting. Materials and Methods. Payor claims data of patients receiving NPWT with (n = 199) or without (n = 232) RTM between January 1 and June 30, 2017 were analyzed. Results. The RTM patients were significantly older (P = .0401), had a higher percentage of Medicare Advantage plans (P = .0015), and had a higher mean Charleston Comorbidity Index score (P = .0115) than non-RTM patients. For both groups, chronic wounds had higher 90-day wound-related costs than acute wounds. The median length of treatment for RTM patients was shorter than non-RTM patients (P = .0394). Mean 90-day wound-related costs for RTM and non-RTM patients were $10 515 and $12 158, respectively. Conclusions. These results build upon previous studies of RTM-assisted outpatient NPWT and suggest an opportunity for wound care cost savings.
C1 [Griffin, Leah; Sifuentes, Mikaela M.] Acelity, 12930 W Interstate 10, San Antonio, TX 78249 USA.
RP Griffin, L (通讯作者)，Acelity, 12930 W Interstate 10, San Antonio, TX 78249 USA.
EM Leah.Griffin@Acelity.com
RI Sifuentes, Mikaela/AAJ-1776-2021
OI Sifuentes, Mikaela/0000-0002-7914-4183
CR Griffin L, 2018, WOUNDS, V30, pE81
   Viswanathan M, 2012, ANN INTERN MED, V157, P785, DOI 10.7326/0003-4819-157-11-201212040-00538
NR 2
TC 4
Z9 5
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2019
VL 31
IS 2
BP E9
EP E11
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV4ZZ
UT WOS:000484282300003
PM 30730299
DA 2026-07-24
ER
PT J
AU Blalock, L
AF Blalock, Lindsey
TI Use of Negative Pressure Wound Therapy With Instillation and a Novel
   Reticulated Open-cell Foam Dressing With Through Holes at a Level 2
   Trauma Center
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation; NPWTi-d; wound care;
   chronic wounds; reticulated open cell foam dressing with through holes;
   ROCF-CC
AB Introduction. Current wound treatment options for complex wounds include advanced wound therapies. One such treatment, negative pressure wound therapy (NPWT), has evolved to include automated instillation of topical wound solutions with a user-specified dwell time (NPWTi-d). A novel reticulated open-cell foam dressing with through holes (ROCF-CC) was developed to assist wound cleansing by removing thick wound exudate and infectious material. Objective. The author's experience using NPWTi-d with ROCF-CC on complex wounds is presented. Materials and Methods. Patients (N = 19) received antibiotics, pain medication (oral or intravenous), and debridement when applicable. The ROCF-CC contact layer with through holes was cut to fit the wound dimensions and placed in the wound bed. The cover layer (without holes) was placed over the contact layer to fill the remainder of the wound bed, including undermined areas. The foam layers were covered with a semi-occlusive drape, and NPWTi-d was initiated by instilling saline or a hypochlorous solution with a 1-minute to 10-minute dwell time followed by 2 to 3.5 hours of negative pressure (-125 mm Hg or -150 mm Hg). Dressing changes were performed every 2 to 3 days. Results. Mean patient age was 57.1 +/- 18.1 years. Common comorbidities included diabetes, obesity, and tobacco use. After an average of 9.0 +/- 6.9 days of therapy, all wounds displayed less malodor, less devitalized tissue, and improved granulation tissue formation. Conclusions. In all 19 cases, adjunctive use of NPWTi-d with ROCF-CC contributed to hospital discharge, wound closure, and successful limb salvage in this patient population.
C1 [Blalock, Lindsey] Integumetrix, Nashville, TN USA.
RP Blalock, L (通讯作者)，Integumetrix, TriStar Skyline Med Ctr, 3441 Dickerson Pike, Nashville, TN 37207 USA.
EM lindsey@integumetrix.com
CR Applewhite Andrew, 2018, Wounds, V30, pS19
   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
   Fernandez L, 2017, Journal of Trauma & Treatment, V06, DOI [10.4172/2167-1222.1000410, 10.4172/2167-1222.1000410, DOI 10.4172/2167-1222.1000410]
   Fluieraru S, 2013, J WOUND CARE, V22, P293, DOI 10.12968/jowc.2013.22.6.293
   Gabriel A, EPLASTY
   Kim PJ, 2018, WOUNDS, pS1
   Kim Paul J, 2015, Surg Technol Int, V26, P51
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Kim PJ, 2013, PLAST RECONSTR SURG, V132, P1569, DOI 10.1097/PRS.0b013e3182a80586
   Kim PJ, 2015, Wounds, V27, pS2
   Rui P., 2014, National Hospital Ambulatory Medical Care Survey: 2014 Emergency Department Summary Tables
   Sen CK, 2009, WOUND REPAIR REGEN, V17, P763, DOI 10.1111/j.1524-475X.2009.00543.x
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
NR 13
TC 12
Z9 12
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2019
VL 31
IS 2
BP 55
EP 58
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV4ZZ
UT WOS:000484282300008
PM 30485170
DA 2026-07-24
ER
PT J
AU Lumpkins, A
   Stanton, T
AF Lumpkins, April
   Stanton, Tamara
TI Benefits of a Patient-centered Remote Therapy Monitoring Program
   Focusing on Increased Adherence to Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE remote therapy monitoring; negative pressure wound therapy; RTM; NPWT;
   patient adherence; patient compliance
AB Introduction. Patient nonadherence to wound care protocols may impact the efficacy of modalities, such as negative pressure wound therapy (NPWT). Recently, a remote therapy monitoring (RTM) system has been devised for use with NPWT for home care patients. Objective. Three home care patients receiving NPWT are presented to examine the relationship between patients using the RTM system and Virtual Therapy Specialists (VTS). Materials and Methods. Consent was secured from patients with either multiple comorbidities and/or wounds of varying complexity. Wounds were assessed as per their initial presentation, and all patients were discharged home with an RTM-equipped NPWT system to apply continuous subatmospheric pressure to their wound. Dressings were changed every 2 to 3 days. Results. All 3 patients were women (age range, 53-72 years), who presented with the following wound types: recalcitrant abdominal wound, acute wound following ventral hernia repair, and dehisced wound following a hysterectomy. Patient 1 was treated with RTM-equipped NPWT for a duration of 88 days (6 nonadherent vs. 82 adherent days) and was adherent to the therapy 93.2% of the time. Patient 2 was treated with RTM-equipped NPWT for a duration of 57 days (8 nonadherent vs. 49 adherent days) and was adherent to the therapy 86.0% of the time. Patient 3 was treated with RTM-equipped NPWT for a duration of 16 days (2 nonadherent vs. 14 adherent days) and was adherent to the therapy 87.5% of the time. Each patient presented with a barrier to therapy adherence (eg, lack of access to residential clinical support, technical issues, or work demands) that was managed by VTS interactions. Conclusions. In these 3 cases, RTM-equipped NPWT and the patient-centric exchanges with the VTS through adherence calls helped promote consistent usage of RTM-equipped NPWT to address the patients' therapeutic needs and increase therapy adherence.
C1 [Lumpkins, April; Stanton, Tamara] KCI, San Antonio, TX USA.
RP Lumpkins, A (通讯作者)，12930 West Interstate 10, San Antonio, TX 78249 USA.
EM April.Lumpkins@Acelity.com
FU KCI, an Acelity Company
FX The authors are employees of KCI, an Acelity Company (San Antonio, TX).
   Financial support for this research was provided by KCI, an Acelity
   Company. Willie M. Heard III, PhD (KCI, an Acelity Company), provided
   medical writing support. These data were presented at the Symposium on
   Advanced Wound Care Fall 2018 in Las Vegas, NV.
CR Griffin L, 2019, WOUNDS, V31, pE9
   Griffin L, 2018, WOUNDS, V30, pE81
   Iuga AO, 2014, RISK MANAG HEALTHC P, V7, P35, DOI 10.2147/RMHP.S19801
   Reach G, 2016, PATIENT PREFER ADHER, V10, P459, DOI 10.2147/PPA.S99627
   Sabate E :., 2003, ADHERENCE LONG TERM
NR 5
TC 1
Z9 2
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2019
VL 31
IS 8
BP E49
EP E53
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV5AI
UT WOS:000484283200002
PM 31483754
DA 2026-07-24
ER
PT J
AU Shen, X
   Zhan, TF
   Wei, DY
   Zhang, HS
AF Shen, Xiao
   Zhan, Tianfu
   Wei, Dayong
   Zhang, Hengshu
TI Comparison of Efficacy and Complications Between Negative Pressure Wound
   Therapy and Conventional Mechanical Fixation in Skin Grafts: A
   Retrospective Analysis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE skin graft; surgical; graft fixation; wound healing; negative pressure
   wound therapy; NPWT; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; BOLSTER
AB Introduction. Graft fixation is critical for the successful survival of a skin graft. Conventional mechanical fixation may induce inappropriate pressure and increase wound complications. Negative pressure wound therapy (NPWT) could be utilized to secure a skin graft and improve drainage. Limited quantitative data exist on the efficacy of NPWT for skin grafting. Objective. This retrospective study compares the efficacy and complications between NPWT and conventional mechanical fixation in skin grafts. Materials and Methods. Patients who underwent skin graft surgery from January 2015 to December 2016 at a large university hospital in southwest China were retrospectively analyzed. Characteristics, including wound pattern, skin graft type, surgical procedure, survival rate, and postoperative complication, were statistically analyzed by Pearson chi-square or Fisher's exact test. Results. A total of 186 patients were included in the study; 72 received NPWT and 114 received conventional mechanical dressing fixation after skin grafting. Overall survival rate of full-thickness skin grafts was significantly higher in the NPWT group than the dressing group (P < .01). The NPWT group showed a higher survival rate than the dressing group for each anatomic site, but only patients who had skin grafts of the hand exhibited statistically significant results. Conclusions. This study reports a quantitative analysis of the efficacy of NPWT on skin graft fixation with NPWT providing consistent pressure and better drainage than conventional mechanical fixation. In addition, the use of NPWT also could increase graft take on the hand region.
C1 [Shen, Xiao; Zhan, Tianfu; Wei, Dayong; Zhang, Hengshu] Chongqing Med Univ, Affiliated Hosp 1, Dept Plast & Burn Surg, Chongqing, Peoples R China.
C3 Chongqing Medical University
RP Zhang, HS (通讯作者)，Dept Plast & Burn Surg, 4 1 You Yi Rd, Chongqing, Peoples R China.
EM 42019142@qq.com
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Kamolz L P, 2014, Ann Burns Fire Disasters, V27, P141
   KCI an Acelity Company, 2014, VAC THER CLIN GUID
   Lee DH, 2016, Journal of Korean Society for Microsurgery, V25, P29, DOI [10.15596/arms.2016.25.2.29, 10.15596/ARMS.2016.25.2.29, DOI 10.15596/ARMS.2016.25.2.29]
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Ross RE, 2011, J WOUND CARE, V20, P490, DOI 10.12968/jowc.2011.20.10.490
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   Weinfeld AB, 2005, ANN PLAS SURG, V54, P178, DOI 10.1097/01.sap.0000143606.39693.3f
NR 17
TC 13
Z9 17
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2019
VL 31
IS 8
BP 213
EP 218
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV5AI
UT WOS:000484283200007
PM 31298660
DA 2026-07-24
ER
PT J
AU Yuan, KZ
   Zhao, B
   Cooper, T
   Jin, ZY
   Zhou, XJ
   Chen, XL
   Li, ZJ
   Gao, WY
   Yan, HD
AF Yuan, Kaizong
   Zhao, Bin
   Cooper, Tokai
   Jin, Zeyuan
   Zhou, Xijie
   Chen, Xinglong
   Li, Zhijie
   Gao, Weiyang
   Yan, Hede
TI The management of degloving injuries of the limb with full thickness
   skin grafting using vacuum sealing drainage or traditional compression
   dressing: A comparative cohort study
SO JOURNAL OF ORTHOPAEDIC SCIENCE
LA English
DT Article
ID CIRCUMFERENTIALLY AVULSED SKIN; TECHNICAL REFINEMENT; ASSISTED CLOSURE;
   THERAPY; EXTREMITIES; FRACTURES; DEEP
AB Background: Degloving injuries of the limb are severe and frequently underrated. Few researches are available comparing the results of reattachment of the degloved skin grafts with the vacuum sealing drainage technique and the traditional compression dressing method. In this study, we aimed to compare the treatment outcomes of these two approaches.
   Methods: Eighty-three consecutive patients were treated for degloving injury of the limb. Based on the treatment approach, the patients were divided into vacuum sealing drainage group (VSD group, n = 55) and traditional compression dressing group (TCD group, n = 28). After reattachment, the degloved skin was secured with stitches and compressed with VSD or TCD. The outcomes were mainly assessed based on the percentage of skin graft take.
   Result: In VSD group, there were excellent results in 18, fair in 9 and poor in 28, respectively; In TCD group, there were excellent results in 11, fair in 10 and poor in 7, respectively. Statistically, no significant difference was found between two groups in terms of the category of excellent results. However, significant higher incidence of poor results with necrotic areas exceeding 50% was observed in the VSD group than that in the TCD group. In addition, although the duration of hospitalization in the VSD group was shorter than that in the TCD group, the medical supply costs and total costs were much higher than that of the TCD group.
   Conclusion: VSD and TCD are equally effective in the management of degloving injuries of the limb; however, VSD technique may potentially have a higher risk of poor results with increased hospital charges. The traditional approach still has its merits in clinical practice, especially in rural hospitals when VSD is not available or unaffordable. (C) 2019 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.
C1 Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, Wenzhou 325000, Peoples R China.
   Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University
RP Yan, HD (通讯作者)，109 XueYuan West Rd, Wenzhou, Zhejiang, Peoples R China.
EM 513740828@qq.com; 969545367@qq.com; coopertokaib@yahoo.com;
   zjwzjzy@yeah.net; 493565783@qq.com; drchenxinglong@126.com;
   lzhjwh@126.com; 996020299@qq.com; yanhede@hotmail.com
RI Chen, Xinglong/ACE-2741-2022
CR Arnez ZM, 2010, J PLAST RECONSTR AES, V63, P1865, DOI 10.1016/j.bjps.2009.11.029
   Beltzer C, 2016, GMS INTERDISCIP PLAS, V5, DOI 10.3205/iprs000098
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   Sakai G, 2017, INJURY, V48, P137, DOI 10.1016/j.injury.2016.10.026
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   Yuan XG, 2016, ORTHOP TRAUMATOL-SUR, V102, P369, DOI 10.1016/j.otsr.2016.01.020
   Zhang Jian, 2009, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V23, P1170
   Zhang Longcheng, 2012, Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V26, P1113
   Zhang Meiguang, 2014, Zhonghua Shao Shang Za Zhi, V30, P116
   Zhang Wei-Kai, 2013, Zhonghua Zheng Xing Wai Ke Za Zhi, V29, P258
   Zhao Xiao-fei, 2014, Zhongguo Gu Shang, V27, P1036
NR 32
TC 11
Z9 16
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0949-2658
EI 1436-2023
J9 J ORTHOP SCI
JI J. Orthop. Sci.
PD SEP
PY 2019
VL 24
IS 5
BP 881
EP 887
DI 10.1016/j.jos.2019.01.002
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA IW2XN
UT WOS:000484844800021
PM 30709789
DA 2026-07-24
ER
PT J
AU Yikemu, X
   Tuxun, A
   Nuermaimaiti, M
   Abudukeyimu, A
   Shayiti, A
AF Yikemu, Xirenijiang
   Tuxun, Aikebaier
   Nuermaimaiti, Mireadili
   Abudukeyimu, Abuduta
   Shayiti, Abuduleaila
TI Effects of Vacuum Sealing Drainage Combined with Ilizarov Bone Transport
   Technique in the Treatment of Tibial Traumatic Osteomyelitis
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Negative-Pressure Wound Therapy; Tissue Expansion Devices; Vacuum
   Extraction, Obstetrical
ID ORTHOFIX LRS; DEFECTS; THERAPY; SALVAGE
AB Background: The aim of this study was to analyze the efficacy of vacuum sealing drainage combined with Ilizarov bone transport technique in the treatment of tibial traumatic osteomyelitis and risk factors for postoperative pin infection.
   Material/Methods: We enrolled 78 patients with tibial traumatic osteomyelitis admitted at the First People's Hospital of Kashgar from January 2015 to September 2017 and treated with vacuum sealing drainage combined with Ilizarov bone transport technique.
   Results: After combined treatment, SAS and SDS scores decreased significantly, while SF-36 scores increased significantly. Comparisons showed that there were significant differences in the scores of patients after treatment (P<0.05). Univariate analysis showed that there were no significant differences in gender, BMI, hypertension, diabetes mellitus, COPD, smoking index, alcohol abuse history, or residence (P>0.05). There were significant differences in age, fracture type, fixation type, pin loosening, and indwelling time between the 2 groups (P<0.05). Multivariate logistic analysis showed that age, fracture type, fixation type, pin loosening, and indwelling time were independent risk factors for pin infection. Age, fracture type, fixation type, pin loosening, and indwelling time are independent risk factors for pin infection in patients with tibial traumatic osteomyelitis.
   Conclusions: Combination of vacuum sealing drainage with Ilizarov bone transport technique can effectively improve the condition of tibial traumatic osteomyelitis, improve the quality of life of patients, and reduce the occurrence of adverse emotions of patients. Age, fracture type, fixation type, pin loosening, and indwelling time are independent risk factors for pin infection in patients with tibial traumatic osteomyelitis.
C1 [Yikemu, Xirenijiang; Tuxun, Aikebaier; Nuermaimaiti, Mireadili; Abudukeyimu, Abuduta; Shayiti, Abuduleaila] First Peoples Hosp Kashgar, Dept Orthoped, Kashgar, Xinjiang, Peoples R China.
RP Shayiti, A (通讯作者)，First Peoples Hosp Kashgar, Dept Orthoped, Kashgar, Xinjiang, Peoples R China.
EM shayiti123@163.com
OI yikemu, xirenijiang/0009-0008-7370-2851
CR Abulaiti A, 2017, INJURY, V48, P2842, DOI 10.1016/j.injury.2017.10.036
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NR 20
TC 13
Z9 20
U1 0
U2 13
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD SEP 12
PY 2019
VL 25
BP 6864
EP 6871
DI 10.12659/MSM.915450
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IW9NQ
UT WOS:000485320800003
PM 31513555
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Khurram, MF
   Ali, SS
   Yaseen, M
AF Khurram, Mohammed Fahud
   Ali, Sheikh Sarfraz
   Yaseen, Mohammad
TI Vacuum-Assisted Wound Closure Therapy in Pediatric Lower Limb Trauma
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE skin graft; wound management; wound care; dressings; NPWT; TNP;
   debridement
ID MANAGEMENT; FRACTURES
AB Although the importance of vacuum-assisted wound closure therapy has been well established as road to definitive treatment of trauma wound in the adult population, its use in pediatric patients is not well described in the literature. This study was conducted to evaluate the outcome of vacuum-assisted wound closure therapy in pediatric patients. Twenty-two patients were prospectively treated for soft tissue defect in lower limb using vacuum-assisted wound closure device, as these wounds were not amenable for primary closure. After wound evaluation, thorough wound debridement was done. Vacuum-assisted wound closure dressing was applied once hemostasis was achieved. Dressings were changed as per protocol. After the development of healthy granulation tissue, wound coverage was achieved with skin graft or flaps. Mean age of patients was 9.455 years, ranging from 4 to 14 years. Early, healthy granulation tissue had formed in all patients. The average number of vacuum-assisted closure (VAC) dressings required was 2.682. Average duration of VAC therapy was 8.045 days. The sizes of soft tissue defects reduced from an average 69.18 cm(2) to 50.73 cm(2) after VAC therapy with a mean decrease of 26.66%. There was no complication because of VAC therapy. Vacuum-assisted wound closure therapy accelerated the process of healthy granulation tissue formation, and thus shortened the healing time. VAC therapy lessens the morbidity and pain associated with large wounds in pediatric patients and brings cheer and smile in growing children.
C1 [Khurram, Mohammed Fahud; Ali, Sheikh Sarfraz; Yaseen, Mohammad] Aligarh Muslim Univ, Jawaharlal Nehru Med Coll & Hosp, Aligarh, Uttar Pradesh, India.
C3 Aligarh Muslim University
RP Ali, SS (通讯作者)，St 8, Aligarh 202001, Uttar Pradesh, India.
EM drsheikhsarfrazaliep@gmail.com
RI Sheikh Sarfraz, Ali/AAJ-5196-2021; khurram, mohammed/I-1773-2019
OI Sheikh Sarfraz, Ali/0000-0003-0093-5511; khurram,
   mohammed/0000-0002-3452-0325
CR [Anonymous], 2009, PRINC BEST PRACT VAC
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baharestani MM, 2007, OSTOMY WOUND MANAG, V53, P75
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
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NR 19
TC 6
Z9 7
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2019
VL 18
IS 3
BP 317
EP 322
DI 10.1177/1534734619857403
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IX9BC
UT WOS:000485981100013
PM 31258007
DA 2026-07-24
ER
PT J
AU Kirsner, R
   Dove, C
   Reyzelman, A
   Vayser, D
   Jaimes, H
AF Kirsner, Robert
   Dove, Cyaandi
   Reyzelman, Alex
   Vayser, Dean
   Jaimes, Henry
TI A prospective, randomized, controlled clinical trial on the efficacy of
   a single-use negative pressure wound therapy system, compared to
   traditional negative pressure wound therapy in the treatment of chronic
   ulcers of the lower extremities
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; EVIDENCE-BASED
   RECOMMENDATIONS; LEG ULCERS; MANAGEMENT; MULTICENTER; COMPRESSION;
   DRESSINGS; STEPS; NPWT
AB Multicenter, phase-4, randomized, comparative-efficacy study in patients with VLUs or DFUs comparing for noninferiority the percentage change in target ulcer dimensions (area, depth, and volume) a single-use negative pressure wound therapy (s-NPWT) system versus traditional NPWT (t-NPWT) over a 12-week treatment period or up to confirmed healing. Baseline values were taken at the randomization visit. Randomized by wound type and size, 164 patients with non-infected DFUs and VLUs were included. The ITT population was composed of 161 patients (101 with VLUs, 60 with DFUs) and 115 patients completed follow-up (64 in the s-NPWT group and 51 in the t-NPWT group) (PP population). The average age for all patients was 61.5 years, 36.6% were women, and treatment groups were statistically similar at baseline. Primary endpoint analyses on wound area reduction demonstrated statistically significant reduction in favor of s-NPWT (p = 0.003) for the PP population and for the ITT population (p < 0.001). Changes in wound depth (p = 0.018) and volume (p = 0.013) were also better with s-NPWT. Faster wound closure was observed with s-NPWT (Cox Proportional Hazards ratio (0.493 (0.273, 0.891); p = 0.019) in the ITT population. Wound closure occurred in 45% of patients in the s-NPWT group vs. 22.2% of patients in the t-NPWT group (p = 0.002). Median estimate of the time to wound closure was 77 days for s-NPWT. No estimate could be provided for t-NPWT due to the low number of patients achieving wound closure. Device-related AEs were more frequent in the t-NPWT group (41 AEs from 29 patients) than in the s-NPWT group (16 AEs from 12 patients). The s-NPWT system met noninferiority and achieved statistical superiority vs. t-NPWT in terms of wound progression toward healing over the treatment period. When NPWT is being considered for the management of challenging VLUs and DFUs, s-NPWT should be considered a first choice over other types of NPWT.
C1 [Kirsner, Robert] Univ Miami, Miller Sch Med, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
   [Dove, Cyaandi] Adv Foot & Ankle Ctr, Las Vegas, NV USA.
   [Reyzelman, Alex] Samuel Merritt Univ, Calif Sch Podiatr Med, Dept Med, San Francisco, CA USA.
   [Reyzelman, Alex] UCSF Ctr Limb Preservat, San Francisco, CA USA.
   [Vayser, Dean] Foot & Ankle Ctr, Dept Orthoped, Scripps Clin Med Grp, Wound Care Div, San Diego, CA USA.
   [Jaimes, Henry] Wounds Smith & Nephew, London, England.
C3 University of Miami; Samuel Merritt University
RP Kirsner, R (通讯作者)，Univ Miami, Miller Sch Med, 1321 NW 14th St,Room 504, Miami, FL 33125 USA.; Jaimes, H (通讯作者)，Hatters Lane,Bldg 5,Croxley Pk, Watford WD18 8YE, England.
EM rkisner@med.miami.edu; henry.jaimes@smith-nephew.com
OI Jaimes, Henry/0000-0001-6526-1963
CR Andrews KL, 2015, PROSTHET ORTHOT INT, V39, P29, DOI 10.1177/0309364614534296
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   NICE (National Institute for Health and Care Excellence), PICO NEG PRESS WOUND
   Rahmanian-Schwarz A, 2012, BURNS, V38, P573, DOI 10.1016/j.burns.2011.10.010
   Sajid MT, 2015, JCPSP-J COLL PHYSICI, V25, P789, DOI 11.2015/JCPSP.789793
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   Schwartz JA, 2015, J WOUND CARE S2, V24, P4
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   Wang RR, 2015, INT J CLIN EXP MED, V8, P12548
NR 40
TC 31
Z9 41
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2019
VL 27
IS 5
BP 519
EP 529
DI 10.1111/wrr.12727
PG 11
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA IY0GP
UT WOS:000486070300010
PM 31087729
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Fernández, L
   Ellman, C
   Jackson, P
AF Fernandez, Luis
   Ellman, Cynthia
   Jackson, Patricia
TI Use of Negative Pressure Wound Therapy With Instillation in the
   Management of Complex Wounds in Critically Ill Patients
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; negative pressure wound therapy with
   instillation and dwell time; NPWT; NPWTi-d; acute wound care;
   reticulated open-cell foam dressing
ID RECOMMENDATIONS
AB Introduction. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) cleanses wounds with cyclic delivery, dwell, and removal of topical solutions to solubilize infectious materials and wound debris. Objective. In this 2-patient case study, the authors report their experiences using NPWTi-d on 2 critically ill patients requiring management of large, complex wounds. Materials and Methods. In both cases, normal saline was instilled with 10- to 20-minute dwell times, followed by 2 hours of negative pressure wound therapy (NPWT) at -125 mm Hg. Results. Patient 1 was a 67-year-old woman, with a history of Roux-en-Y gastric bypass surgery, who required emergency surgery about 36 hours after ischemic efferent limb detorsion. After damage control surgery, NPWTi-d was applied for about 2 weeks. Once the wound was granulating, treatment was switched to conventional NPWT. Definitive surgery was planned for once she became physiologically optimized. Patient 2 was a 45-year-old woman presenting with septic shock and complex, necrotic wounds due to Fournier's gangrene. She received appropriate debridement, antibiotics, and adjunctive nutritional and critical care support. Then, NPWTi-d and NPWT were applied for 68 days, after which split-thickness skin grafts were used to close the right thigh, inguinal area, perineum, suprapubic area, right superior buttocks region, and back. Conventional NPWT was applied over the grafts as a bolster, and the patient was discharged to a rehabilitation center 27 days later with a 95% graft take. Conclusions. In the authors' clinical experience, NPWTi-d promoted wound healing in critically ill patients with large wounds.
C1 [Fernandez, Luis; Ellman, Cynthia; Jackson, Patricia] Christus Trinity Mother Frances Hosp, Tyler, TX USA.
RP Fernández, L (通讯作者)，Christus Trinity Mother Frances Hlth Syst, 910 E Houston St, Tyler, TX 75702 USA.
EM thebigkahuna115@gmail.com
RI FERNANDEZ, LUIS/O-7657-2019
CR Gupta S, 2016, INT WOUND J, V13, P159, DOI 10.1111/iwj.12452
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Kim PJ, 2015, Wounds, V27, pS2
   McKanna M, 2016, OSTOMY WOUND MANAG, P3
NR 4
TC 8
Z9 11
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2019
VL 31
IS 1
BP E1
EP E4
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IY2MT
UT WOS:000486225600003
PM 30694212
DA 2026-07-24
ER
PT J
AU Maráz, R
   Venczel, L
   Sikorszki, L
   Serfozo, O
   Ambrózay, E
   Patyi, M
   Cserni, G
AF Maraz, Robert
   Venczel, Laszlo
   Sikorszki, Laszlo
   Serfozo, Orsolya
   Ambrozay, Eva
   Patyi, Marta
   Cserni, Gabor
TI Negative pressure wound therapy of Corynebacterium jeikeium associated
   granulomatous mastitis
SO BREAST JOURNAL
LA English
DT Article
DE Corynebacterium; granulomatous mastitis; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE
AB We present the first Corynebacterium associated therapy resistant granulomatous mastitis successfully treated with negative pressure wound therapy (NPWT). Our patient had received five different courses of antibiotic therapy, and three surgical explorations before NPWT was introduced and resulted in healing. For a successful treatment, the use of targeted antibiotic therapy, steroid therapy and in case of progressive disease, wide excision is required. When this results in a large wound cavity, NPWT seems an effective and innovative option.
C1 [Maraz, Robert; Venczel, Laszlo; Sikorszki, Laszlo] Bacs Kiskun Cty Hosp, Dept Surg, Kecskemet, Hungary.
   [Serfozo, Orsolya; Ambrozay, Eva] MaMMa Clin, Kecskemet, Hungary.
   [Patyi, Marta] Bacs Kiskun Cty Hosp, Dept Infectol, Kecskemet, Hungary.
   [Cserni, Gabor] Bacs Kiskun Cty Hosp, Dept Pathol, Kecskemet, Hungary.
   [Cserni, Gabor] Univ Szeged, Dept Pathol, Szeged, Hungary.
C3 Szeged University
RP Maráz, R (通讯作者)，Cty Hosp, Dept Surg, Nyiri Ut 38, H-6000 Kecskemet, Hungary.
EM marazrobert2010@gmail.com
RI ; Cserni, Gabor/JCN-6784-2023
OI Venczel, Laszlo/0000-0003-2651-7772; Maráz, Róbert/0000-0003-0146-6024; 
CR [Anonymous], PLOS MED
   Co M, 2018, PATHOLOGY, V50, P742, DOI 10.1016/j.pathol.2018.08.010
   Joseph E, 2000, WOUNDS, V12, P60
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Renshaw AA, 2011, AM J CLIN PATHOL, V136, P424, DOI 10.1309/AJCP1W9JBRYOQSNZ
   Taylor GB, 2003, PATHOLOGY, V35, P109, DOI 10.1080/0031302031000082197
NR 6
TC 3
Z9 4
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1075-122X
EI 1524-4741
J9 BREAST J
JI Breast J.
PD MAR
PY 2020
VL 26
IS 3
BP 508
EP 510
DI 10.1111/tbj.13573
EA SEP 2019
PG 3
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA KW0DV
UT WOS:000486300800001
PM 31512310
OA Green Accepted
DA 2026-07-24
ER
PT J
AU Escobar-Vidarte, MF
   Messa, A
   Nieto, AJ
   Echavarría, MP
   Carvajal, JA
   Fernández, PA
AF Fernanda Escobar-Vidarte, Maria
   Messa, Adriana
   Jose Nieto, Albaro
   Paula Echavarria, Maria
   Andres Carvajal, Javier
   Andrea Fernandez, Paula
TI Use of Negative Pressure Wound Therapy in Surgical Site Infection During
   Pregnancy A Case Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Negative pressure wound therapy; Pregnancy; Surgical site infection;
   Wound infection; Wound management
ID CESAREAN-SECTION; HIGH-RISK; COMPLICATIONS
AB BACKGROUND: Surgical site infections (SSIs) are a known cause of morbidity and mortality; however, evidence related to management of SSIs during pregnancy is sparse. CASE: A 26-year-old female patient with an adnexal cystic lesion underwent laparotomy at 19 weeks of pregnancy. She experienced a late SSI 10 days after initial surgery, necessitating surgical debridement. She was treated with multiple surgical interventions for wound irrigations and wound closure assisted by a negative pressure wound therapy. CONCLUSION: Negative pressure wound therapy was used for treatment of an SSI during pregnancy without causing premature delivery or requiring a cesearan section.
C1 [Fernanda Escobar-Vidarte, Maria; Messa, Adriana; Jose Nieto, Albaro; Paula Echavarria, Maria; Andres Carvajal, Javier] Fdn Clin Valle Del Lili, Dept Gynecol & Obstet, Cali, Colombia.
   [Andrea Fernandez, Paula] Fdn Clin Valle del Lili, Clin Invest Ctr, Cali, Colombia.
RP Escobar-Vidarte, MF (通讯作者)，Fdn Clin Valle de Lili, Dept Gynecol & Obstet, Carrera 98 18-49, Cali, Colombia.
EM mayaev@hotmail.com
RI Nieto-Calvache, Albaro/AAJ-8485-2021; Escobar-Vidarte, María
   F/R-7501-2016
OI Escobar-Vidarte, María F/0000-0002-1441-0890
CR Anglim B, 2015, J OBSTET GYNAECOL, V35, P255, DOI 10.3109/01443615.2014.958442
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NR 17
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2019
VL 46
IS 5
BP 453
EP 456
DI 10.1097/WON.0000000000000573
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA IZ3ZY
UT WOS:000487025300014
PM 31513134
DA 2026-07-24
ER
PT J
AU Reiter, G
   Thomas, B
   Kühner, C
   Hundeshagen, G
   Weil, F
   Wittenberg, G
   Kloos, S
   Grützner, PA
   Kneser, U
AF Reiter, G.
   Thomas, B.
   Kuehner, C.
   Hundeshagen, G.
   Weil, F.
   Wittenberg, G.
   Kloos, S.
   Gruetzner, P. A.
   Kneser, U.
TI Reconstruction of lower limbs in old age-an interdisciplinary approach
   Strategies for trauma surgery, vascular surgery and plastic surgery
SO CHIRURG
LA German
DT Article
DE Geriatric trauma; Vascular surgical reconstruction; Osteosynthesis;
   Plastic surgery; Interdisciplinary trauma treatment
ID FREE-FLAP RECONSTRUCTION; SOFT-TISSUE COVERAGE; DISTAL LOWER LEG;
   LOWER-EXTREMITY; BALLOON ANGIOPLASTY; PERONEUS BREVIS; RISK-FACTORS;
   FRACTURES; DEFECTS; MUSCLE
AB The treatment of complex injuries of the lower extremities in geriatric and/or multimorbid patients requires optimized preoperative and perioperative management as well as differentiated and interdisciplinary surgical approaches. Timely and definitive treatment should be strived for to avoid longer periods of immobilization. Temporary external stabilization of complex fractures, when necessary, should be followed by permanent loading stable internal osteosynthesis as soon as possible. Accompanying soft tissue defects are reconstructed after wound debridement using the full armamentarium of plastic and reconstructive surgical procedures, including microvascular free flap. In the context of perfusion compromised soft tissue situations, negative pressure wound therapy can provide sterile temporary defect coverage and aid in preconditioning poorly vascularized tissue before definitive reconstruction. A clarification of the vascular status in geriatric patients is paramount and relevant perfusion disorders should be treated either by intervention or open surgery before complex reconstructive interventions. Close interdisciplinary coordination of the various surgical procedures is imperative in order to guarantee an optimized stable reconstructive outcome with acceptable patient risk. Taking these principles into account, the reconstruction of complex trauma to the extremities can be carried out even in geriatric or multimorbid patients in specialized interdisciplinary surgical centers with excellent functional results.
C1 [Reiter, G.; Weil, F.; Gruetzner, P. A.] BG Unfallklin Ludwigshafen, Sekt Sept Chirurg, Klin Unfallchirurg & Orthopad, Ludwig Guttmann Str 13, Ludwigshafen, Germany.
   [Thomas, B.; Hundeshagen, G.; Kneser, U.] BG Unfallklin Ludwigshafen, Schwerbrandverletztenzentrum, Klin Hand Plast & Rekonstrukt Chirurg, Ludwigshafen, Germany.
   [Thomas, B.; Hundeshagen, G.; Kneser, U.] Heidelberg Univ, Klin Plast & Handchirurg, Heidelberg, Germany.
   [Kuehner, C.; Kloos, S.] Klinikum Stadt Ludwigshafen, Klin Gefasschirurg, Ludwigshafen, Germany.
   [Wittenberg, G.] BG Unfallklin Ludwigshafen, Klin Anasthesie Intens Med & Schmerztherapie, Ludwigshafen, Germany.
C3 Ruprecht Karls University Heidelberg; Ludwigshafen Hospital
RP Reiter, G (通讯作者)，BG Unfallklin Ludwigshafen, Sekt Sept Chirurg, Klin Unfallchirurg & Orthopad, Ludwig Guttmann Str 13, Ludwigshafen, Germany.
EM gregor.reiter@bgu-ludwigshafen.de
RI Thomas, Benjamin/HPI-2516-2023
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   Wong AK, 2015, MICROSURG, V35, P6, DOI 10.1002/micr.22223
   Wong CH, 2007, ANN PLAS SURG, V58, P614, DOI 10.1097/01.sap.0000250839.37161.ce
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NR 51
TC 5
Z9 5
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD OCT
PY 2019
VL 90
IS 10
SI SI
BP 806
EP 815
DI 10.1007/s00104-019-01023-7
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JA2KN
UT WOS:000487645700005
PM 31501936
DA 2026-07-24
ER
PT J
AU Muenchow, S
   Horch, RE
   Dragu, A
AF Muenchow, S.
   Horch, R. E.
   Dragu, A.
TI Effects of topical negative pressure therapy on perfusion and
   microcirculation of human skin
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Topical negative pressure wound therapy; tissue - laser/photo -
   spectrometry; microvascular tissue perfusion
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; LASER-DOPPLER; SOCIETY
AB BACKGROUND: Topical negative pressure wound therapy (TNPWT) is one of the most frequently used techniques in wound treatment. But some of the underlying mechanisms still remain unclear. One possible explanation is an improved microcirculation by TNPWT.
   OBJECTIVE: This study investigated the influence of TNPWT on microcirculation on intact skin in real-time.
   METHODS: In healthy individuals, we performed a combined tissue - laser/photo - spectrometry technique to monitor changes of 4 different microcirculation parameters in real-time: The local blood flow, the capillary-venous oxygen saturation, the blood flow velocity and the relative amount of hemoglobin. We compared these parameters using two different protocols: a continuously (VAC ON 60/OFF 60) and discontinuously (VAC ON 30/OFF 60/ON 5) application.
   RESULTS: Our results demonstrate a significant increase of all four measured parameters during the active TNPWT and the pressure free period. The comparison of two different protocols shows an advantage of the examined parameters using a discontinuous TNPWT application.
   CONCLUSIONS: Our study demonstrated the changes of the microvascular tissue perfusion in intact human skin under the conditions of negative pressure and may thereby offer a broader understanding of mechanisms underlying the TNPWT.
C1 [Muenchow, S.; Dragu, A.] Tech Univ Dresden, Dept Plast & Hand Surg, Univ Hosp Dresden, Fac Med Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany.
   [Muenchow, S.; Horch, R. E.] Friedrich Alexander Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Univ Hosp, Erlangen, Germany.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   University of Erlangen Nuremberg
RP Dragu, A (通讯作者)，Tech Univ Dresden, Dept Plast & Hand Surg, Univ Hosp Dresden, Fac Med Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany.
EM adrian.dragu@uniklinikum-dresden.de
RI Dragu, Adrian/AAH-3506-2019; Horch, Raymund/H-8128-2019
OI Dragu, Adrian/0000-0003-4633-2695; 
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NR 31
TC 32
Z9 35
U1 0
U2 0
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2019
VL 72
IS 4
BP 365
EP 374
DI 10.3233/CH-180536
PG 10
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA JA8EJ
UT WOS:000488082600004
PM 30909192
DA 2026-07-24
ER
PT J
AU Namgoong, S
   Jung, SY
   Han, SK
   Kim, AR
   Dhong, ES
AF Namgoong, Sik
   Jung, Su-Young
   Han, Seung-Kyu
   Kim, Ae-Ree
   Dhong, Eun-Sang
TI Clinical experience with surgical debridement and simultaneous meshed
   skin grafts in treating biofilm-associated infection: an exploratory
   retrospective pilot study
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Biofilm; diabetic ulcer; negative pressure wound therapy; skin graft;
   surgical debridement
ID IN-VITRO; WOUNDS
AB Current treatment guidelines for biofilm-associated infections (BAI) recommend repeated sharp/surgical debridement followed by treatment with antimicrobial agents until the wound becomes self-sustaining in terms of a positive wound-healing trajectory. However, complete removal of a biofilm is unlikely, and biofilms reform rapidly. We have treated BAI in patients with chronic diabetic ulcers using a meshed skin graft combined with negative pressure wound therapy (NPWT) immediately after surgical debridement, rather than waiting until the development of clean and healthy granulation tissue; the purpose of this exploratory study was to report the clinical results of this treatment strategy. This retrospective study included 75 patients with chronic diabetic ulcers who were treated for BAI by using surgical debridement, simultaneous meshed skin grafts, and NPWT. Healing time along with the percentage of complete wound closure within 12?weeks were evaluated; bacteria isolated from the wounds and their relation to the wound healing rate were investigated. All 75 wounds healed successfully, and the mean time for complete wound healing was 3.5???1.8?weeks. In particular, 76% of wounds healed uneventfully without graft loss. A mean of 3.3 bacterial colonies/wound were isolated; however, no significant difference in wound healing was observed between the monomicrobial and polymicrobial groups. This exploratory study suggests that surgical debridement and simultaneous meshed skin grafts combined with NPWT may be successfully used to combat BAI in patients with chronic diabetic ulcers. We look forward to larger pivotal studies to confirm or refute these initially promising findings.
C1 [Namgoong, Sik; Han, Seung-Kyu; Dhong, Eun-Sang] Korea Univ Coll Med, Dept Plast Surg, Seoul, South Korea.
   [Jung, Su-Young] Armed Forces Capital Hosp, Dept Plast Surg, Seongnam, South Korea.
   [Kim, Ae-Ree] Korea Univ, Dept Pathol, Coll Med, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine)
RP Han, SK (通讯作者)，Korea Univ, Dept Plast Surg, Guro Hosp, 148 Guro Dong, Seoul 08308, South Korea.
EM pshan@kumc.or.kr
RI Namgoong, Sik/ABB-7842-2021
OI Namgoong, Sik/0000-0002-4200-7089; Dhong, Eun Sang/0000-0002-7521-0518
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NR 25
TC 18
Z9 24
U1 1
U2 11
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD JAN 2
PY 2020
VL 54
IS 1
BP 47
EP 54
DI 10.1080/2000656X.2019.1673170
EA OCT 2019
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA KQ5QP
UT WOS:000488411100001
PM 31575315
OA gold
DA 2026-07-24
ER
PT J
AU Wells, CI
   Ratnayake, CBB
   Perrin, J
   Pandanaboyana, S
AF Wells, Cameron, I
   Ratnayake, Chathura B. B.
   Perrin, Jenni
   Pandanaboyana, Sanjay
TI Prophylactic Negative Pressure Wound Therapy in Closed Abdominal
   Incisions: A Meta-analysis of Randomised Controlled Trials
SO WORLD JOURNAL OF SURGERY
LA English
DT Review
ID SURGICAL SITE INFECTION; COLORECTAL SURGERY; CARE; PREVENTION;
   MANAGEMENT; CLOSURE; COMPLICATIONS; LAPAROTOMY; IMPACT; RISK
AB Introduction Negative pressure wound therapy (NPWT) may prevent subcutaneous fluid accumulation in a closed wound and subsequently reduce surgical site infections (SSI). This meta-analysis aimed to determine the effect of prophylactic NPWT on SSI incidence following abdominal surgery. Methods A systematic search of MEDLINE and EMBASE databases was performed using PRISMA methodology. All randomised trials reporting the use of NPWT in closed abdominal incisions were included, regardless of the type of operation. The primary outcome measure was the incidence of SSI, stratified by superficial and deep and organ/space infections. Secondary outcomes were wound dehiscence and length of hospital stay. Results Ten randomised trials met the inclusion criteria (five Caesarean, five midline laparotomy). The use of NPWT reduced overall SSI (11.6% vs. 16.7%, RR 0.67, 95% CI 0.48-0.95, p = 0.02). The rate of superficial SSI rate was also reduced (6.3% vs. 11.3%, RR 0.57, 95% CI 0.35-0.94, p = 0.03). There was no effect on deep or organ/space SSI (3.2% vs. 4.2%, RR 0.77, 95% CI 0.51-1.18, p = 0.23), wound dehiscence (9.7% vs. 10.9%, RR 0.92, 95% CI 0.69-1.21, p = 0.54), or length of hospital stay (MD 0.06 days, 95% CI-0.11 to 0.23, p = 0.51). Conclusions Prophylactic use of NPWT may reduce the incidence of superficial SSI in closed abdominal incisions but has no effect on deep or organ space SSI.
C1 [Wells, Cameron, I; Ratnayake, Chathura B. B.; Perrin, Jenni; Pandanaboyana, Sanjay] Univ Auckland, Fac Med & Hlth Sci, Dept Surg, Auckland, New Zealand.
   [Pandanaboyana, Sanjay] Newcastle Upon Tyne NHS Trust, Dept HPB & Transplant Surg, Freeman Hosp, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England.
C3 University of Auckland; Newcastle Upon Tyne Hospitals NHS Foundation
   Trust; Newcastle Freeman Hospital
RP Pandanaboyana, S (通讯作者)，Univ Auckland, Fac Med & Hlth Sci, Dept Surg, Auckland, New Zealand.; Pandanaboyana, S (通讯作者)，Newcastle Upon Tyne NHS Trust, Dept HPB & Transplant Surg, Freeman Hosp, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England.
EM sanjay.pandanaboyana@nuth.nhs.uk
RI ; Wells, Cameron/AFP-7151-2022; pandanaboyana, sanjay/U-2626-2019
OI Ratnayake, Bathiya/0000-0002-5188-9124; 
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NR 64
TC 37
Z9 42
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD NOV
PY 2019
VL 43
IS 11
BP 2779
EP 2788
DI 10.1007/s00268-019-05116-6
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JB8SX
UT WOS:000488847800018
PM 31396673
DA 2026-07-24
ER
PT J
AU Huang, HP
   Zhao, WJ
   Pu, J
   He, F
AF Huang, Hua-Ping
   Zhao, Wen-Jun
   Pu, Jia
   He, Fang
TI Prophylactic negative pressure wound therapy for surgical site infection
   in obese women undergoing cesarean section: an evidence synthesis with
   trial sequential analysis*
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Article
DE Cesarean section; complication; negative pressure wound therapy; obese
ID DELIVERY; COMPLICATIONS; PREVENTION; MANAGEMENT; RISK
AB Objective: Current evidence for negative pressure wound therapy (NPWT) on surgical site infection (SSI) and wound complications in cesarean section is conflicting. The objective of this study was to evaluate the efficacy of prophylactic NPWT for preventing SSI and other wound complications in obese women undergoing cesarean section (CS). Methods: We systematically searched PubMed, Embase, the Cochrane Library and clinicaltTrial.gov to identify randomized controlled trials (RCTs) that compared NPWT with standard dressing for cesarean section. The primary outcome was SSI. Secondary outcomes were overall wound complications and hospital readmission. Risk ratio (RR) with 95% confidence intervals (CIs) was calculated using random-effects models. Review Manager 5.3 was applied to analyze the collected data. Results: Eight RCTs involving 1972 patients were included in this meta-analysis. The pooled results showed that the risk of SSI was significantly lower with the use of NPWT when compared with standard dressing (RR = 0.68, 95%CI = 0.51-0.90, p = .008). However, there was no difference in overall wound complications (RR = 0.93, 95%CI = 0.74-1.17, p = 0.52) and hospital readmission (RR = 1.03, 95%CI = 0.67-1.60, p = .89) between two groups. Current evidence was not confirmed by trial sequential analysis. Conclusion: On the basis of our findings, NPWT decreases the risk of SSI after cesarean section in obese women after CS, despite this approach does not reduce the overall wound complications and hospital readmission. However, further RCTs are needed to make conclusive evidence.
C1 [Huang, Hua-Ping; Zhao, Wen-Jun] Mianyang Cent Hosp, Dept Operat Room, Mianyang, Sichuan, Peoples R China.
   [Pu, Jia] North Sichuan Med Coll, Dept Nursing, Nanchang, Jiangxi, Peoples R China.
   [He, Fang] Mianyang Cent Hosp, Dept Nursing Adm, Mianyang, Sichuan, Peoples R China.
C3 North Sichuan Medical University
RP Huang, HP (通讯作者)，Mianyang Cent Hosp, Dept Operat Room, 12 Changjia Alley,Jingzhong St, Mianyang, Fucheng Distric, Peoples R China.
EM jrzhou26@aliyun.com
RI Huang, Huaping/G-5523-2016; Pu, Jiamin/KTH-7490-2024
OI Huang, Huaping/0000-0002-0534-2718; 
CR Ayres-de-Campos D, 2015, BEST PRACT RES CL OB, V29, P406, DOI 10.1016/j.bpobgyn.2014.08.009
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NR 27
TC 16
Z9 18
U1 2
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD AUG 3
PY 2021
VL 34
IS 15
BP 2498
EP 2505
DI 10.1080/14767058.2019.1668924
EA SEP 2019
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA SO9PO
UT WOS:000489480800001
PM 31530067
DA 2026-07-24
ER
PT J
AU Kim, JH
   Kim, HJ
   Lee, DH
AF Kim, Jun-Ho
   Kim, Hyun-Jung
   Lee, Dae-Hee
TI Comparison of the Efficacy Between Closed Incisional Negative-Pressure
   Wound Therapy and Conventional Wound Management After Total Hip and Knee
   Arthroplasties: A Systematic Review and Meta-Analysis
SO JOURNAL OF ARTHROPLASTY
LA English
DT Review
DE closed incisional negative-pressure wound therapy; surgical site
   infection; total hip arthroplasty; total knee arthroplasty; wound
   complication
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; REVISION HIP; ECONOMIC
   BURDEN; COMPLICATIONS; PREVENTION; DRESSINGS; SURGERY; GUIDELINE; INDEX
AB Background: Wound-related problems after total hip arthroplasty (THA) and total knee arthroplasty (TKA) can cause periprosthetic joint infections. We sought to evaluate the effect of closed incisional negative-pressure wound therapy (ciNPWT) on wound complications, skin blisters, surgical site infections (SSIs), reoperations, and length of hospitalization (LOH).
   Methods: Studies comparing ciNPWT with conventional dressings following THA and TKA were systematically searched on MEDLINE, Embase, and the Cochrane Library. Two reviewers performed the study selection, risk of bias assessment, and data extraction. Funnel plots were employed to evaluate publication bias and forest plots to analyze pooled data.
   Results: Twelve studies were included herein. The odds ratios (ORs) for wound complications and SSIs indicated a lack of publication bias. ciNPWT showed significantly lower risks of wound complication (OR, 0.44; 95% confidence interval [CI], 0.22-0.9; P = .027) and SSI (OR, 0.39; 95% CI, 0.23-0.68; P < .001) than did conventional dressings. ciNPWT also yielded a significantly lower reoperation rate (OR, 0.38; 95% CI, 0.21-0.69; P = .001) and shorter LOH (mean difference, 0.41 days; 95% CI, -0.51 to -0.32; P < .001). However, the rate of skin blisters was higher in ciNPWT (OR, 4.44; 95% CI, 2.24-8.79; P < .001).
   Conclusion: Although skin blisters were more likely to develop in ciNPWT, the risks of wound complication, SSI, reoperation, and longer LOH decreased in ciNPWT compared with those in conventional dressings. This finding could alleviate the potential concerns regarding wound-related problems after THA and TKA. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Kim, Jun-Ho; Lee, Dae-Hee] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Orthoped Surg, 81 Irwon Ro, Seoul 06351, South Korea.
   [Kim, Hyun-Jung] Korea Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Korea
   University; Korea University Medicine (KU Medicine)
RP Lee, DH (通讯作者)，Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Orthoped Surg, 81 Irwon Ro, Seoul 06351, South Korea.
RI ; Lee, Dae-Hee/I-9390-2017
OI Kim, Hyun Jung/0000-0003-2018-2385; Lee, Dae-Hee/0000-0003-3147-8763
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NR 47
TC 38
Z9 44
U1 0
U2 6
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD NOV
PY 2019
VL 34
IS 11
BP 2804
EP 2814
DI 10.1016/j.arth.2019.06.020
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA JD0UN
UT WOS:000489692100047
PM 31288945
DA 2026-07-24
ER
PT J
AU Zoeller, C
   Yoshizawa, E
   Sethi, MV
   Ure, BM
   Kuebler, JF
AF Zoeller, Christoph
   Yoshizawa, Emi
   Sethi, Mohammad V.
   Ure, Benno M.
   Kuebler, Joachim F.
TI Negative Pressure Wound Dressing Reduces Surgical Site Infections in
   Infants after Closed Abdominal Procedures: A Preliminary Report
SO EUROPEAN JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE negative pressure wound dressing; surgical site infection;
   clean-contaminated; contaminated; dirty abdominal procedure; infants
ID VACUUM-ASSISTED CLOSURE; THERAPY; INCISION; LAPAROTOMY; SURGERY;
   COMPLICATIONS; MECHANISMS; PREVENTION; COST
AB Introduction Negative pressure wound therapy (NPWT) is a novel tool to reduce surgical site infections (SSIs). Although SSIs are a common source of morbidity in infants undergoing laparotomy, the cost of the available NPWT devices has restricted its use to adult high-risk patients. We developed a low-cost method of NPWT in infants and analyzed its impact on the incidence of SSIs in infant patients.
   Materials and Methods A consecutive series of infants (age <= 12 months) who underwent a clean-contaminated, contaminated, or dirty abdominal procedure via laparotomy from 08/2015 to 12/2016 were included. The choice of the applied dressing, either NPWT or standard surgical dressing (SSD), was made at the surgeon's discretion. SSIs were documented prospectively. The Horan definition and the Clavien-Dindo classification were used. The cost of material was calculated for both groups.
   Results Ninety-three consecutive patients were included (65 SSD and 28 NPWT). SSI occurred in 10 patients in the SSD group, Grade I in 7 and Grade II in 3 (Clavien-Dindo classification). No SSI occurred in patients with NPWT (p < 0.05). The cost of an SSD was less than 1 (sic), and the cost of a NPWT was less than 10 (sic).
   Conclusion The routine use of this modified vacuum wound dressing may be an efficient and affordable technique to decrease SSIs in infants who underwent contaminated abdominal operations.
C1 [Zoeller, Christoph; Yoshizawa, Emi; Sethi, Mohammad V.; Ure, Benno M.; Kuebler, Joachim F.] Hannover Med Sch, Dept Pediat Surg, Carl Neuberg Str 1, D-30625 Hannover, Germany.
C3 Hannover Medical School
RP Zoeller, C (通讯作者)，Hannover Med Sch, Dept Pediat Surg, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM zoeller.christoph@mh-hannover.de
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NR 24
TC 5
Z9 6
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0939-7248
EI 1439-359X
J9 EUR J PEDIATR SURG
JI Eur. J. Pediatr. Surg.
PD AUG
PY 2019
VL 29
IS 4
BP 384
EP 387
DI 10.1055/s-0038-1660448
PG 4
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA JD1LS
UT WOS:000489736800011
PM 29920637
DA 2026-07-24
ER
PT J
AU Pawar, DRL
   Jeyapalina, S
   Hafer, K
   Bachus, KN
AF Pawar, Divya R. L.
   Jeyapalina, Sujee
   Hafer, Kelli
   Bachus, Kent N.
TI Influence of negative pressure wound therapy on peri-prosthetic tissue
   vascularization and inflammation around porous titanium percutaneous
   devices
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE percutaneous devices; negative pressure wound therapy; skin downgrowth;
   wound healing; peri-prosthetic tissue
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; SOFT-TISSUE;
   MACROPHAGE PHENOTYPE; SKIN; MODEL; ANGIOGENESIS; EXPRESSION; INTERFACE;
   MECHANISM
AB Negative Pressure Wound Therapy (NPWT) has been shown to limit downgrowth around percutaneous devices in a guinea pig model. However, the influence of NPWT on periprosthetic tissue characteristics leading to limited downgrowth is still unclear. In order to investigate this, 12 CD hairless rats were assigned into two groups, NPWT and Untreated (n = 6/group). Each animal was implanted with a porous coated titanium percutaneous device and was dressed with a gauze and semi-occlusive base dressing. Post-surgery, animals in the NPWT Group received a regimen of NPWT treatment (-70 to -90 mmHg). After 4 weeks, tissue was collected over the device and stained with CD31 and CD68 to quantify blood vessel density and inflammation, respectively. The device with the surrounding tissue was also collected to quantify downgrowth. NPWT treatment led to a 1.6-fold increase in blood vessel densities compared to untreated tissues (p < 0.05). NPWT treatment also resulted in half the downgrowth as the Untreated Group, although not statistically significant (p = 0.19). Additionally, the results showed a trend toward increased CD68 cell densities in the NPWT Group compared to the Untreated Group (p = 0.09). These findings suggest that NPWT may influence wound healing responses in percutaneous devices by increasing blood vessel densities, limiting downgrowth and potentially increasing inflammation. Overall, NPWT may enhance tissue vascularity around percutaneous devices, especially in patients with impaired wound healing. (c) 2019 Wiley Periodicals, Inc.
C1 [Pawar, Divya R. L.; Jeyapalina, Sujee; Bachus, Kent N.] George E Wahlen Dept Vet Affairs Med Ctr, Orthopaed Res Labs, Salt Lake City, UT 84148 USA.
   [Pawar, Divya R. L.; Jeyapalina, Sujee; Bachus, Kent N.] Univ Utah, Orthopaed Ctr, Salt Lake City, UT 84148 USA.
   [Pawar, Divya R. L.; Hafer, Kelli; Bachus, Kent N.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
   [Jeyapalina, Sujee] Univ Utah, Sch Med, Dept Surg, Salt Lake City, UT 84132 USA.
C3 US Department of Veterans Affairs; Utah System of Higher Education;
   University of Utah; Utah System of Higher Education; University of Utah;
   Utah System of Higher Education; University of Utah
RP Bachus, KN (通讯作者)，George E Wahlen Dept Vet Affairs Med Ctr, Orthopaed Res Labs, Salt Lake City, UT 84148 USA.; Bachus, KN (通讯作者)，Univ Utah, Orthopaed Ctr, Salt Lake City, UT 84148 USA.; Bachus, KN (通讯作者)，Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
EM kent.bachus@va.gov
RI Bachus, Kent/KYO-7869-2024
FU Department of Orthopaedics, University of Utah School of Medicine, Salt
   Lake City, Utah; LS-Peery Program in Musculoskeletal Restoration, Salt
   Lake City, UT; US Army Medical Research and Materiel Command
   [W81XWH-15-C-0058]; United States Department of Veterans Affairs
   Rehabilitation Research and Development Service [I01RX001217,
   I01RX001246]
FX Contract grant sponsor: Department of Orthopaedics, University of Utah
   School of Medicine, Salt Lake City, UtahContract grant sponsor: LS-Peery
   Program in Musculoskeletal Restoration, Salt Lake City, UTContract grant
   sponsor: US Army Medical Research and Materiel Command; contract grant
   number: W81XWH-15-C-0058Contract grant sponsor: United States Department
   of Veterans Affairs Rehabilitation Research and Development Service;
   grant numbers: I01RX001217, I01RX001246
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NR 45
TC 6
Z9 6
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD AUG
PY 2019
VL 107
IS 6
BP 2091
EP 2101
DI 10.1002/jbm.b.34302
PG 11
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA JD4VY
UT WOS:000489979100033
PM 30629801
OA Bronze
DA 2026-07-24
ER
PT J
AU Bussell, HR
   Aufdenblatten, CA
   Gruenenfelder, C
   Altermatt, S
   Tharakan, SJ
AF Bussell, Hannah Rachel
   Aufdenblatten, Christoph Alexander
   Gruenenfelder, Corina
   Altermatt, Stefan
   Tharakan, Sasha Job
TI Comparison of lower extremity fasciotomy wound closure techniques in
   children: vacuum-assisted closure device versus temporary synthetic skin
   replacement
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Compartment syndrome; Lower extremity; Child; Fasciotomy; V; A; C;
   device
ID ACUTE COMPARTMENT SYNDROME; LOWER LEG; FRACTURES; MANAGEMENT; PRESSURES;
   DIAGNOSIS
AB Purpose No clear consensus on the optimal treatment of fasciotomy wounds due to acute compartment syndrome of the lower leg in children exists. We therefore compared two commonly used methods to close fasciotomy wounds, Epigard, a temporary synthetic skin replacement (SSR) and the vacuum-assisted closure (V.A.C.) device, in respect of treatment duration and complication rates. Methods We studied the cases of 27 patients who were treated at our institution for acute compartment syndrome of the lower leg with a fasciotomy over a 10-year period. The fasciotomy wound was either treated with SSR or V.A.C. device. We recorded the number of procedures to definitive wound closure, days to wound closure, hospitalization days and sequelae rate. Results In the V.A.C. device group (18 patients) the mean number of procedures until definitive wound closure was 3.1, mean days until wound closure was 9.4 and mean days of hospitalization was 16.2. One patient suffered from a wound infection and one patient required a full thickness skin graft. In the SSR group (9 patients), the mean number of procedures was 1.8, mean days until definitive wound closure was 4.9 and mean days of hospitalization was 9.9. No sequelae were recorded. There was a statistically significant smaller number of procedures (p value 0.018), fewer days to definitive wound closure (p value 0.002) and fewer hospitalization days (p value 0.005) in the SSR group. Conclusions Both SSR and V.A.C. device are safe and reliable for closure of fasciotomy wounds in children, whereas SSR seems to lead to shorter time until definitive wound closure.
C1 [Bussell, Hannah Rachel; Aufdenblatten, Christoph Alexander; Altermatt, Stefan; Tharakan, Sasha Job] Univ Childrens Hosp Zurich, Dept Pediat Surg, Steinwiessstr 75, CH-8032 Zurich, Switzerland.
C3 University Children's Hospital Zurich
RP Bussell, HR (通讯作者)，Univ Childrens Hosp Zurich, Dept Pediat Surg, Steinwiessstr 75, CH-8032 Zurich, Switzerland.
EM hannah.bussell@kispi.uzh.ch
OI Neeser Bussell, Hannah Rachel/0000-0002-7182-3181
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NR 19
TC 3
Z9 5
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD OCT
PY 2019
VL 45
IS 5
BP 809
EP 814
DI 10.1007/s00068-018-0985-9
PG 6
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA JD5FT
UT WOS:000490009600006
PM 30014272
DA 2026-07-24
ER
PT J
AU Cicuttin, E
   Ansaloni, L
   Ceresoli, M
   Fugazzola, P
   Tomasoni, M
   Sartelli, M
   Catena, F
   Coccolini, F
   Montori, G
   Salvetti, F
   Zese, M
   Occhionorelli, S
   Galatioto, C
   Chiarugi, M
   Dondossola, D
   Novelli, G
   Nacoti, M
   Costa, S
   Zoro, T
   Trotta, F
   Rausei, S
   Bellanova, G
   Costa, G
   Porta, M
   Mariani, F
   Lora, F
   Fattori, L
   Jacopo, V
   Lorenzo, C
AF Cicuttin, Enrico
   Ansaloni, Luca
   Ceresoli, Marco
   Fugazzola, Paola
   Tomasoni, Matteo
   Sartelli, Massimo
   Catena, Fausto
   Coccolini, Federico
   Montori, Giulia
   Salvetti, Francesco
   Zese, Monica
   Occhionorelli, Savino
   Galatioto, Christian
   Chiarugi, Massimo
   Dondossola, Daniele
   Novelli, Giuseppe
   Nacoti, Mirco
   Costa, Stefano
   Zoro, Tamara
   Trotta, Francesco
   Rausei, Stefano
   Bellanova, Giovanni
   Costa, Gianluca
   Porta, Matteo
   Mariani, Federico
   Lora, Federico
   Fattori, Luca
   Jacopo, Vigano
   Lorenzo, Cobianchi
CA Italian IROA Study Grp
TI Trends in open abdomen management in Italy: a subgroup analysis from the
   IROA project
SO UPDATES IN SURGERY
LA English
DT Article
DE Open abdomen; Management; Laparostomy; Complication; Mortality;
   Morbidity; Peritonitis; Pancreatitis; Trauma; Vascular emergency;
   Register; Fistula; IROA
ID ABDOMINAL COMPARTMENT SYNDROME; CLOSURE
AB Use of open abdomen (OA) progressively acquired increasing importance with the diffusion of the damage control management of critical patients. The purpose of the present study is to identify the state of the art about the use of OA in Italy, focusing on techniques, critical issues and clinical outcomes. A prospective analysis of adult patients enrolled in the IROA, limited to the Italian participating centres was performed. 375 patients were enrolled. Mean age was 64 +/- 16 years old, 56% of the patients were male, mean BMI was 26.9 +/- 5.2. Main indications for using OA were secondary peritonitis (32.5%), post-operative peritonitis (22.9%) and trauma (11.7%). Main OA techniques used were commercial negative pressure wound therapy (49.6%) and Bogota bag (27.7%). Definitive closure of the abdomen was reached in 82.4% of patients after 6 +/- 7 days of OA. The primary fascia closure rate was 84.7%. Overall mortality was 29.1%. The complication rate was 50.8%, with an enteroatmospheric fistula incidence: 7.5%. A univariate analysis performed on complication type found the duration of OA treatment (p = 0.024) to be statistically significant. Univariate analysis on mortality risk identified as significant age, duration of OA (in days) and pancreatitis as indication; multivariate analysis confirmed age (p < 0.001) and pancreatitis (p = 0.002) as statistically significant. A large variety of behaviours towards the patient requiring OA exists. A strong acceptance of common, recognized and evidence-based guidelines is essential, to obtain more uniformity in patient management and coherence of collected data, thus leading to improvement in outcomes and reduction of costs.
C1 [Cicuttin, Enrico; Ansaloni, Luca; Fugazzola, Paola; Tomasoni, Matteo; Coccolini, Federico; Salvetti, Francesco] Bufalini Hosp, Gen Emergency & Trauma Surg Dept, Viale Giovanni Ghirotti 286, I-47521 Cesena, Italy.
   [Cicuttin, Enrico; Zoro, Tamara; Lorenzo, Cobianchi] Univ Pavia, Dipartimento Sci Clin Chirurg Diagnost & Pediat, Pavia, Italy.
   [Ceresoli, Marco; Fattori, Luca] Milano Bicocca Univ, Gen & Emergency Surg, Sch Med & Surg, Monza, Italy.
   [Sartelli, Massimo] Macerata Hosp, Gen & Emergency Surg, Macerata, Italy.
   [Catena, Fausto] Parma Univ Hosp, Emergency Surg Dept, Parma, Italy.
   [Montori, Giulia] San Giovanni Bianco Hosp, Gen Surg, Bergamo, Italy.
   [Zese, Monica; Occhionorelli, Savino] Ferrara Univ Hosp, Emergency Surg Dept, Ferrara, Italy.
   [Galatioto, Christian; Chiarugi, Massimo] Azienda Osped Univ Pisana, Pisa, Italy.
   [Dondossola, Daniele] Fdn IRCCS Ca Granda Osped Maggiore Policlin, HPB Surg, Milan, Italy.
   [Novelli, Giuseppe] Infermi Hosp, Gen Surg, Rimini, Italy.
   [Nacoti, Mirco] Papa Giovanni XXIII Hosp, Pediat Intens Care Unit, Bergamo, Italy.
   [Costa, Stefano] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Emergency & Gen Surg, Milan, Italy.
   [Trotta, Francesco] Osped Maggiore Lodi, Lodi, Italy.
   [Rausei, Stefano] Univ Insubria, Osped Circolo & Fdn Macchi, Varese, Italy.
   [Bellanova, Giovanni] SS Annunziata Hosp, Taranto, Italy.
   [Costa, Gianluca] Osped St Andrea Univ Hosp Sapienza, Rome, Italy.
   [Porta, Matteo] IRCCS Policlin San Donato, Gen Surg, Milan, Italy.
   [Mariani, Federico] Santa Maria Scotte Univ Hosp, Gen Surg, Siena, Italy.
   [Lora, Federico] Citta Salute & Sci, Gen Surg, Turin, Italy.
   [Jacopo, Vigano] Fdn IRCCS Policlin San Matteo, Chirurg Gen 1, Pavia, Italy.
C3 University of Pavia; University of Milano-Bicocca; University of Parma;
   University Hospital of Parma; University of Ferrara; Arcispedale
   Sant'Anna; University of Pisa; Azienda Ospedaliero Universitaria Pisana;
   IRCCS Ca Granda Ospedale Maggiore Policlinico; Hospital of Rimini; ASST
   Papa Giovanni XXIII; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   Ospedale Maggiore di Lodi; University of Insubria; Ospedale Circolo &
   Fondazione Macchi; IRCCS Policlinico San Donato; University of Siena;
   University Hospital of Siena; A.O.U. Citta della Salute e della Scienza
   di Torino; IRCCS Fondazione San Matteo
RP Coccolini, F (通讯作者)，Bufalini Hosp, Gen Emergency & Trauma Surg Dept, Viale Giovanni Ghirotti 286, I-47521 Cesena, Italy.
EM federico.coccolini@gmail.com
RI Ceresoli, Marco/GMW-5356-2022; Novelli, Giuseppe/A-5195-2013; Cobianchi,
   Lorenzo/AAC-2282-2022; Cicuttin, Enrico/GXG-6365-2022; Occhionorelli,
   Savino/AAB-2552-2022; Tomasoni, Matteo/AAC-3732-2022; Rausei,
   Stefano/AAM-7898-2021; /AAD-7440-2020; Costa, Gianluca/ABD-7262-2020;
   Ansaloni, Luca/AAP-9134-2020; dondossola, daniele/A-7978-2016; Ansaloni,
   Luca/AAJ-6507-2020; Fugazzola, Paola/AAH-4680-2019; Chiarugi,
   Massimo/ABQ-7280-2022; Porta, Matteo/AAQ-4219-2021; Nacoti,
   Mirco/AFV-9624-2022; Montori, Giulia/ABF-9661-2020
OI Cicuttin, Enrico/0000-0003-4584-9940; Zese, Monica/0000-0002-4768-6746;
   Costa, Gianluca/0000-0001-5194-8908; Salvetti,
   Francesco/0000-0001-8472-5823; Ansaloni, Luca/0000-0001-6427-0307;
   dondossola, daniele/0000-0002-4374-3184; Ansaloni,
   Luca/0000-0001-6427-0307; Fugazzola, Paola/0000-0002-6227-9276;
   Chiarugi, Massimo/0000-0001-6905-2499; Porta,
   Matteo/0000-0002-5787-4433; Nacoti, Mirco/0000-0002-8737-9812; Montori,
   Giulia/0000-0002-7649-2174
CR Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
   Burlew CC, 2011, J TRAUMA, V70, P273, DOI 10.1097/TA.0b013e3182050eb7
   Coccolini F, 2019, INJURY, V50, P160, DOI 10.1016/j.injury.2018.09.040
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
   Coccolini F, 2017, WORLD J EMERG SURG, V12, DOI 10.1186/s13017-017-0146-1
   Coccolini F, 2017, WORLD J EMERG SURG, V12, DOI 10.1186/s13017-017-0123-8
   Demetriades D, 2014, SURG CLIN N AM, V94, P131, DOI 10.1016/j.suc.2013.10.010
   Kirkpatrick AW, 2013, INTENS CARE MED, V39, P1190, DOI 10.1007/s00134-013-2906-z
   Miller RS, 2005, J TRAUMA, V59, P1365, DOI 10.1097/01.ta.0000196004.49422.af
   Mintziras I, 2016, LANGENBECK ARCH SURG, V401, P619, DOI 10.1007/s00423-016-1443-y
   Regner JL, 2012, WORLD J SURG, V36, P497, DOI 10.1007/s00268-011-1203-7
   Sartelli M, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0032-7
   van Brunschot S, 2014, PANCREAS, V43, P665, DOI 10.1097/MPA.0000000000000108
   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
NR 14
TC 6
Z9 7
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD MAR
PY 2020
VL 72
IS 1
BP 171
EP 177
DI 10.1007/s13304-019-00687-4
EA OCT 2019
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KU7IL
UT WOS:000490890200002
PM 31621034
DA 2026-07-24
ER
PT J
AU Inatomi, Y
   Kadota, H
   Yoshida, S
   Kamizono, K
   Shimamoto, R
   Fukushima, S
   Miyashita, K
   Matsuo, M
   Yasumatsu, R
   Tanaka, S
   Fukushima, J
AF Inatomi, Yusuke
   Kadota, Hideki
   Yoshida, Sei
   Kamizono, Kenichi
   Shimamoto, Ryo
   Fukushima, Seita
   Miyashita, Kayo
   Matsuo, Mioko
   Yasumatsu, Ryuji
   Tanaka, Shunichiro
   Fukushima, Junichi
TI Utility of negative-pressure wound therapy for orocutaneous and
   pharyngocutaneous fistula following head and neck surgery
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Article
DE fistula closure; head and neck cancer; negative-pressure wound therapy;
   orocutaneous fistula; pharyngocutaneous fistula
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Background Because of the difficulty of airtight sealing and risk of salivary contamination, negative-pressure wound therapy (NPWT) has rarely been applied for postoperative fistula following head and neck surgery; thus, its utility remains unclear. Methods We applied NPWT in 34 patients who developed orocutaneous and pharyngocutaneous fistula after head and neck surgery. Here we retrospectively analyzed the utility of NPWT for managing those fistulas. Results Thirty-two patients (94.1%) underwent NPWT as scheduled without adverse events. In 28 patients (82.4%), fistula closure was completed only by NPWT, and the mean period to fistula closure was 30.4 days. The mean period to closure did not differ significantly between fistulas with (21.7 days) and without (39.1 days) previous irradiation. Conclusions Airtight sealing can be maintained and postoperative fistula can be closed by NPWT with a high success rate, even after previous irradiation. NPWT is an effective and minimally invasive treatment for postoperative fistula.
C1 [Inatomi, Yusuke; Kadota, Hideki; Yoshida, Sei; Kamizono, Kenichi; Shimamoto, Ryo; Fukushima, Seita; Miyashita, Kayo] Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, Fukuoka, Fukuoka, Japan.
   [Matsuo, Mioko; Yasumatsu, Ryuji] Kyushu Univ, Dept Otorhinolaryngol, Grad Sch Med Sci, Fukuoka, Fukuoka, Japan.
   [Tanaka, Shunichiro] Kitakyushu Municipal Med Ctr, Dept Otorhinolaryngol, Fukuoka, Fukuoka, Japan.
   [Fukushima, Junichi] Natl Hosp Org Kyushu Canc Ctr, Dept Plast & Reconstruct Surg, Fukuoka, Fukuoka, Japan.
C3 Kyushu University; Kyushu University; Kyushu Cancer Center
RP Inatomi, Y (通讯作者)，Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan.
EM xkxmy557@gmail.com
RI Kadota, Hideki/AAU-7710-2020; Yasumatsu, Ryuji/JXN-7804-2024
OI Kadota, Hideki/0000-0001-7833-3524; 
CR Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Asher SA, 2014, JAMA FACIAL PLAST SU, V16, P120, DOI 10.1001/jamafacial.2013.2163
   Asher SA, 2014, JAMA OTOLARYNGOL, V140, P143, DOI 10.1001/jamaoto.2013.6143
   Dhir K, 2009, LARYNGOSCOPE, V119, P54, DOI 10.1002/lary.20000
   Galli J, 2005, OTOLARYNG HEAD NECK, V133, P689, DOI 10.1016/j.otohns.2005.07.025
   Jacobson LK, 2017, JPRAS OPEN, V13, P92, DOI [10.1016/j.jpra.2017.04.001, 10.1016/j.jpra.2017.04.001, DOI 10.1016/J.JPRA.2017.04.001]
   Johnston JJ, 2013, NEW ZEAL MED J, V126, P74
   Khanh NT, 2015, World Journal of Otorhinolaryngology, V5, P93, DOI [10.5319/wjo.v5.i4.93, DOI 10.5319/WJO.V5.I4.93]
   Kiyokawa K, 2007, PLAST RECONSTR SURG, V120, P1257, DOI 10.1097/01.prs.0000279332.27374.69
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   Rosenthal EL, 2005, HEAD NECK-J SCI SPEC, V27, P970, DOI 10.1002/hed.20265
   Tian B, 2016, HEAD NECK-J SCI SPEC, V38, pE2523, DOI 10.1002/hed.24563
   Tian B, 2014, HEAD NECK-J SCI SPEC, V36, P873, DOI 10.1002/hed.23393
   Yoshida T, 2011, JPN J HEAD NECK CANC, V37, P439
NR 15
TC 15
Z9 21
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD JAN
PY 2020
VL 42
IS 1
BP 103
EP 110
DI 10.1002/hed.25989
EA OCT 2019
PG 8
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA QI0DU
UT WOS:000491180100001
PM 31617619
DA 2026-07-24
ER
PT J
AU Katsogridakis, E
   Pokusevski, G
   Perricone, V
AF Katsogridakis, Emmanuel
   Pokusevski, Goran
   Perricone, Vittorio
TI The role of sartorius muscle flaps in the management of complex groin
   wounds
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Review; Sartorius muscle flap; Myoplasty; Rotational flap
AB A best evidence topic in vascular surgery was written according to a structured protocol. The question addressed was whether sartorius muscle flaps (SMF) can be effectively used in the setting of complex groin wounds with exposed prosthetic grafts for graft salvage and limb salvage. The literature review identified 33 articles reporting on the use of SMF for complex vascular wounds. Of these, 7 articles reporting on the use of 539 SMFs were considered the best evidence to answer the clinical question. Indications included surgical site infections with or without wound dehiscence, lymph leaks, graft infection and groin pseudoaneurysms, whereas in 98 of the included 539 cases, the flaps were performed prophylactically. Vacuum-assisted closure systems were used in 25 cases to promote healing. The use of an SMF is associated with low rates of muscle flap and graft complications, whereas outcomes seem to be independent of the presence of occlusive disease in the superficial femoral artery. They can be effectively combined with aggressive debridement strategies and vacuum-assisted closure devices to optimize outcomes. The published literature supports the use of SMF in the management of complex groin wounds following vascular reconstruction and is associated with encouraging flap, limb and graft salvage rates.
C1 [Katsogridakis, Emmanuel; Perricone, Vittorio] East Lancashire Hosp NHS Trust, Royal Blackburn Hosp, Dept Vasc Surg, Blackburn, Lancs, England.
   [Katsogridakis, Emmanuel] Univ Hosp South Manchester, Educ & Res Ctr, Acad Surg Unit, Southmoor Rd, Manchester M23 9LT, Lancs, England.
   [Pokusevski, Goran] Tameside & Glossop Integrated Care NHS Fdn Trust, Dept Surg, Tameside, England.
C3 Wythenshawe Hospital NHS Foundation Trust
RP Katsogridakis, E (通讯作者)，Univ Hosp South Manchester, Educ & Res Ctr, Acad Surg Unit, Southmoor Rd, Manchester M23 9LT, Lancs, England.
EM e.katsogridakis@nhs.net
OI Katsogridakis, Emmanuel/0000-0001-8551-3910
CR Armstrong PA, 2007, J VASC SURG, V46, P71, DOI 10.1016/j.jvs.2007.02.058
   Brewer MB, 2015, AM SURGEON, V81, P1163
   Dunning Joel, 2003, Interact Cardiovasc Thorac Surg, V2, P405, DOI 10.1016/S1569-9293(03)00191-9
   Fischer JP, 2013, J PLAST RECONSTR AES, V66, P1396, DOI 10.1016/j.bjps.2013.06.014
   Landry GJ, 2009, AM J SURG, V197, P655, DOI 10.1016/j.amjsurg.2008.12.020
   Mirzabeigi MN, 2017, ANN VASC SURG, V43, P232, DOI 10.1016/j.avsg.2017.02.010
   Ryu Dong Yeon, 2016, Vasc Specialist Int, V32, P11, DOI [10.5758/vsi.2016.32.1.11, 10.5758/vsi.2016.32.1.11]
   Töpel I, 2011, J VASC SURG, V53, P1014, DOI [10.1016/j.jvs.2010.11.047, 10.1016/j.jvs.2010.10.047]
NR 8
TC 8
Z9 9
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD APR
PY 2019
VL 28
IS 4
BP 635
EP 637
DI 10.1093/icvts/ivy300
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA JF2YB
UT WOS:000491251000021
PM 30445497
OA Bronze
DA 2026-07-24
ER
PT J
AU Bohbot, S
AF Bohbot, Serge
TI Combining Negative Pressure Wound Therapy With a Lipidocolloid Dressing
   n the Management of Acute and Chronic Wounds: Results of Clinical Study
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
ID EXPERIENCE
C1 [Bohbot, Serge] URGO Med, Ft Worth, TX 76107 USA.
RP Bohbot, S (通讯作者)，URGO Med, Ft Worth, TX 76107 USA.
CR Banwell P E, 2003, J Wound Care, V12, P22
   Blanchet-Bardon C, 2005, J Wound Care, V14, P490
   Blanchet-Bardon C, 2005, J WOUND CARE, V14, P494
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   Fraccalvieri M, 2011, INT WOUND J, V8, P492, DOI 10.1111/j.1742-481X.2011.00821.x
   Krasner Diane L, 2002, Ostomy Wound Manage, V48, P38
   Letouze A, 2004, J Wound Care, V13, P221
   Meaume S, 2004, J Wound Care, V13, P409
   Sibbald R Gary, 2003, Ostomy Wound Manage, V49, P52
   Terrazas SG, 2006, OSTOMY WOUND MANAG, V52, P16
   Unver Seher, 2018, Ostomy Wound Manage, V64, P38, DOI 10.25270/owm.2018.12.3848
   Upton D, 2013, J WOUND CARE, V22, P552, DOI 10.12968/jowc.2013.22.10.552
   Upton D, 2013, J WOUND CARE, V22, P34, DOI 10.12968/jowc.2013.22.1.34
   Waldie K., 2013, BR J NURS, V22, pS18
   Waldie Karen, 2013, Br J Nurs, V22, pS15
   Wetzel-Roth W, 2004, ZBL CHIR, V129, pS7, DOI 10.1055/s-2004-822677
   White R, 2015, SUPPORTING EVIDENCE
NR 17
TC 0
Z9 0
U1 0
U2 1
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD MAR
PY 2019
VL 65
IS 3
BP 9
EP 13
PG 4
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA JF6AB
UT WOS:000491468800003
DA 2026-07-24
ER
PT J
AU Cwalinski, J
   Hermann, J
   Banasiewicz, T
   Paszkowski, J
AF Cwalinski, Jaroslaw
   Hermann, Jacek
   Banasiewicz, Tomasz
   Paszkowski, Jacek
TI Atypical and Life-threatening Crohn's Disease Following Colectomy: A
   Case Report
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE case study; Crohn's Disease; postoperative complications; medical
   nutrition therapy; negative pressure wound therapy
ID POSTOPERATIVE COMPLICATIONS; MANAGEMENT; RELAPAROTOMY; THERAPY; FISTULA
AB Although Crohn's Disease (CD) usually occurs between the second and third decade of life, it also may develop in older adults.Treating elderly patients may be challenging due to other comorbidities, including diverticular disease or intestinal ischemia.PURPOSE: The purpose of this case study was to describe successful treatment of atypical and life-threatening CD due to enterocutaneous fistulas with short-bowel syndrome and multiorgan failure after partial colectomy. CASE REPORT: After an urgent colectomy for an inflammatory colon tumor, a 64-year-old woman with a history of CD and multiple comorbidities developed acute small bowel ischemia. Following an extended bowel resection, she developed a severe surgical site infection,entero- and gastrocutaneous fistulas, multi organ failure, and short bowel syndrome. Her care included intensive medical and nutritional treatment as well as negative pressure wound therapy (NPWT) using continuous negative pressure of -80 mm Hg.She not only survived, but she also achieved complete wound closure and restoration of digestive tract continuity and metabolic control. She was discharged with a central venous catheter on total parenteral nutrition. CONCLUSION: In this case study,a good outcome was observed using intensive medical treatment, nutritional therapy, and conservative surgical treatment that included NPWT for a patient with CD and major comorbidities who developed postoperative complications.
C1 [Cwalinski, Jaroslaw; Hermann, Jacek; Banasiewicz, Tomasz; Paszkowski, Jacek] Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Przbyszewskiego 49, PL-60355 Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Cwalinski, J (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Przbyszewskiego 49, PL-60355 Poznan, Poland.
EM jaroslaw.cwalinski@gmail.com
CR Alhagamhmad MH, 2018, NUTR CLIN PRACT, V33, P483, DOI 10.1002/ncp.10004
   Banasiewicz T, 2011, VIDEOSURGERY MINIINV, V6, P155, DOI 10.5114/wiitm.2011.24694
   Blaser AR, 2020, CLIN NUTR, V39, P151, DOI 10.1016/j.clnu.2019.01.005
   Bobkiewicz A, 2017, INT WOUND J, V14, P255, DOI 10.1111/iwj.12597
   Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
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   Ching SS, 2003, INT J CLIN PRACT, V57, P333
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
   Davis B, 2013, SURG CLIN N AM, V93, P61, DOI 10.1016/j.suc.2012.09.014
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   Gribovskaja-Rupp I, 2016, CLIN COLON RECT SURG, V29, P130, DOI 10.1055/s-0036-1580732
   Horisberger K, 2015, CHIRURG, V86, P1083, DOI 10.1007/s00104-015-0099-4
   Katz Seymour, 2008, Gastroenterol Hepatol (N Y), V4, P337
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   Palma Rios Hugo, 2018, Wounds, V30, pE1
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   Schlussel AT, 2017, AM J SURG, V214, P931, DOI 10.1016/j.amjsurg.2017.04.016
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   Yamamoto T, 2000, DIS COLON RECTUM, V43, P249, DOI 10.1007/BF02236990
NR 25
TC 0
Z9 0
U1 0
U2 3
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD JUL
PY 2019
VL 65
IS 7
BP 36
EP 40
DI 10.25270/wmp.2019.7.3640
PG 5
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA JF7JE
UT WOS:000491561700006
PM 31373562
DA 2026-07-24
ER
PT J
AU Li, ZR
   Yu, QW
   Wang, S
   Wang, GQ
   Li, TT
   Tang, PF
   Liu, DH
AF Li, Zhirui
   Yu, Qingwen
   Wang, Song
   Wang, Guoqi
   Li, Tongtong
   Tang, Pei-fu
   Liu, Daohong
TI Impact of negative-pressure wound therapy on bacterial behaviour and
   bioburden in a contaminated full-thickness wound
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bioluminescent imaging; contamination; infection; negative-pressure
   wound therapy; wound management
ID VACUUM-ASSISTED CLOSURE; INFECTION; OUTCOMES; SYSTEM
AB The use of negative-pressure wound therapy (NPWT) has displayed significant clinical benefits in the healing of infected wounds. However, the effects of NPWT on bacterial colonisation and infection of traumatic wounds has been controversial. The aim of this study is to evaluate the impact of NPWT treatment in rabbits with a contaminated full-thickness wound on bacterial behaviour, including colony morphology, spatial distribution, fissional proliferation, and bacterial bioburden. Full-thickness wounds were created on the back of rabbits, and were inoculated with bioluminescent Staphylococcus aureus. The wounds were treated with sterile gauze dressings and NPWT with continuous negative pressure (-125 mm Hg). Wound samples were harvested on days 0 (6 hours after bacterial inoculation), 2, 4, 6, and 8 at the centre of wound beds before irrigation. Scanning electron microscopy and transmission electron microscopy (TEM) analyses were performed to determine the characteristic bacteriology. Laser scanning confocal microscopy was performed to obtain bioluminescent images, which were used to observe spatial distribution of the GFP-labelled S. aureus within the tissue and quantify the bacterial bioburden. NPWT resulted in sparse amounts of scattered bacteria on the wound surface or as sparsely spaced single colonies within the tissue. Wound bioburden on day 8 in the NPWT and gauze groups was 34.6 +/- 5.5% and 141.9 +/- 15.4% of the baseline values (N = 6), respectively (P < .0001). TEM showed a lack of S. aureus active fission within NPWT-treated tissue. NPWT can impact S. aureus colony morphology and spatial distribution both on the surface and within wound tissue, and reduce S. aureus as early as 48 hours after therapy initiation. Additionally, NPWT inhibits bacterial fissional proliferation in microcolonies.
C1 [Li, Zhirui; Wang, Guoqi; Tang, Pei-fu] Peoples Liberat Army, Dept Orthoped, Gen Hosp, Beijing 100853, Peoples R China.
   [Li, Zhirui] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Sanya, Peoples R China.
   [Li, Zhirui] Hainan Branch, Sanya, Peoples R China.
   [Yu, Qingwen; Liu, Daohong] PLA, Hosp 309, Dept Orthoped, Beijing 100091, Peoples R China.
   [Wang, Song] Nankai Univ, Coll Med, Tianjin, Peoples R China.
   [Li, Tongtong] Tianjin Hosp, Dept Orthoped, Tianjin, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Nankai University; Tianjin University
RP Tang, PF (通讯作者)，Peoples Liberat Army, Dept Orthoped, Gen Hosp, Beijing 100853, Peoples R China.; Liu, DH (通讯作者)，PLA, Hosp 309, Dept Orthoped, Beijing 100091, Peoples R China.
EM pftang301@163.com; domb@vip.sina.com
RI Li, Zhirui/OJT-0490-2025
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NR 24
TC 16
Z9 19
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2019
VL 16
IS 5
BP 1214
EP 1221
DI 10.1111/iwj.13197
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA JG7RQ
UT WOS:000492273200018
PM 31483575
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Drossos, G
   Ampatzidou, F
   Baddour, A
   Madesis, A
   Karaiskos, T
AF Drossos, George
   Ampatzidou, Fotini
   Baddour, Antonios
   Madesis, Athanasios
   Karaiskos, Theodoros
TI The impact of deep sternal wound infections treated by negative pressure
   on early, 1 year and late mortality: A longitudinal case-control study
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
DE cardiac surgery; deep sternal wound infection; mortality; negative
   pressure
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; LONG-TERM
   SURVIVAL; THERAPY; MANAGEMENT; SURGERY
AB Background/Aim Deep sternal wound infection (DSWI) after cardiac surgery, is a rare complication that can be fatal. Due to a lack of available data, we compared early in-hospital, 1-year and long-term mortality in patients with DSWI. Methods Patients undergoing any type of cardiac surgery, in the Cardiothoracic Surgery Department of G. Papanikolaou Hospital, between May 2012 and December 2016, were investigated. All patients who developed DWSI postoperatively, treated with negative pressure wound therapy (NPWT), were included in the group of cases. A random population from the rest of the patients was selected in a 1:2 ratio, representing controls. Results From a total of 2104 patients, 80 patients (3.8%) developed DSWI (cases group), whereas 180 patients were randomly selected as controls. Early (within 30 days) mortality was significantly higher in the DSWI group compared with controls (15% vs 3.9%, respectively; P = .002). Similarly, more deaths occurred in the cases group compared with controls during the follow-up (ie, 19 vs 12, respectively; P < .001); the majority of deaths (84.2%) occurred within the first year. Long-term survival did not differ between the two study groups during follow-up (median duration = 1072 vs 1022 days for cases and controls, respectively). Conclusions DSWI significantly increased early and 1-year mortality in poststernotomy patients treated with NPWT compared with those not developing this complication. However, long-term survival was similar between the two study groups, thus highlighting the beneficial effect of NPWT in terms of clinical outcomes in patients with DWSI.
C1 [Drossos, George; Baddour, Antonios; Madesis, Athanasios; Karaiskos, Theodoros] G Papanikolaou Gen Hosp, Dept Cardiothorac Surg, Thessaloniki, Greece.
   [Ampatzidou, Fotini] G Papanikolaou Gen Hosp, Cardiothorac Intens Care Unit, Thessaloniki 57010, Greece.
C3 George Papanikolaou General Hospital of Thessaloniki; George
   Papanikolaou General Hospital of Thessaloniki
RP Ampatzidou, F (通讯作者)，G Papanikolaou Gen Hosp, Cardiothorac Intens Care Unit, Thessaloniki 57010, Greece.
EM fampatzidou@gmail.com
RI MADESIS, ATHANASIOS/HLW-5269-2023
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NR 27
TC 9
Z9 9
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD DEC
PY 2019
VL 34
IS 12
BP 1550
EP 1555
DI 10.1111/jocs.14296
EA OCT 2019
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA JU0IZ
UT WOS:000492605800001
PM 31654592
DA 2026-07-24
ER
PT J
AU Grande, R
   Brachini, G
   Sterpetti, AV
   Borrelli, V
   Serra, R
   Pugliese, F
   D'Ermo, G
   Tartaglia, E
   Rubino, P
   Mingoli, A
   Sapienza, P
AF Grande, Raffaele
   Brachini, Gioia
   Sterpetti, Antonio V.
   Borrelli, Valeria
   Serra, Raffaele
   Pugliese, Francesco
   D'Ermo, Giuseppe
   Tartaglia, Elvira
   Rubino, Paolo
   Mingoli, Andrea
   Sapienza, Paolo
TI Local release of metalloproteinases and their inhibitors after a
   successful revascularisation procedure
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE advanced moist wound dressing; CLI; infrapopliteal vein graft; MMPs;
   non-healing ulcers; NPWT; TIMPs
ID CRITICAL LIMB ISCHEMIA; MATRIX METALLOPROTEINASES; RISK STRATIFICATION;
   GROWTH-FACTOR; SURGICAL REVASCULARIZATION; STIMULATION; GUIDELINES;
   AMPUTATION; OUTCOMES; THERAPY
AB An altered balance between metalloproteinases (MMPs) and their inhibitor tissue inhibitor of metalloproteinases (TIMPs) may influence the healing process of a minor amputation following a successful vein graft. To speed up this process, negative pressure wound therapy (NPWT) and advanced moist wound dressing have been proposed. We determined the systemic and local release of MMP-1, -2, -3, -9, TIMP-1, and TIMP-2 by enzyme linked immunosorbent assay (ELISA) technique and their influences in the healing process in 26 patients who underwent minor amputation after a successful revascularisation procedure. Twelve patients (group 1) were medicated with NPWT and 14 (group 2) with advanced moist wound dressing. Plasma samples were collected on the morning of surgery and thereafter at 1, 3, and 5 months; exudates were collected 3 days after surgery when amputation was performed and thereafter at 1, 3, and 5 months. Fifteen age-matched healthy male volunteers served as controls. All wounds healed in 5 +/- 0.5 months. Follow-up plasma and local release of MMP-1, -2, -3, and -9 were overall significantly lower when compared with the preoperative levels, while those of TIMP-1 and -2 were significantly higher with no differences among the groups. Despite no differences in the healing process being observed among the two types of medications, at 1 month the local release of MMP-2 and -9 was significantly lower (P = .013 and .047, respectively) and that of TIMP-1 was significantly higher (P = .042) in group 1 as compared to group 2. A correct and aggressive local approach to the wound is able to promote the healing of the lesion stimulating the extracellular matrix turnover with local MMP/TIMP adequate balance and favouring the creation of granulation tissue. However, a successful restoration of an adequate blood flow remains the key point of a durable and rapid wound healing.
C1 [Grande, Raffaele; Brachini, Gioia; Sterpetti, Antonio V.; D'Ermo, Giuseppe; Mingoli, Andrea; Sapienza, Paolo] Sapienza Univ Rome, Dept Surg Pietro Valdoni, Rome, Italy.
   [Borrelli, Valeria] Sapienza Univ Rome, Dept Diagnost Med, Rome, Italy.
   [Serra, Raffaele] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Catanzaro, Italy.
   [Pugliese, Francesco] Sapienza Univ Rome, Dept Emergency, Rome, Italy.
   [Tartaglia, Elvira] Ctr Hosp Sud Francilienne, Dept Gen & Vasc Surg, Paris, France.
   [Rubino, Paolo] Civil Hosp, Dept Vasc Surg, Catanzaro, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Magna Graecia
   University of Catanzaro; Sapienza University Rome
RP Sapienza, P (通讯作者)，Sapienza Univ Rome, Policlin Umberto I, Dept Surg Pietro Valdoni, Surg, Viale Policlin 151, I-00161 Rome, Italy.
EM paolo.sapienza@uniroma1.it
RI D'ERMO, Giuseppe/ABI-1150-2020; Grande, Raffaele/AAO-1388-2020;
   Sapienza, Paolo/AAL-7381-2020; Serra, Raffaele/AAA-6874-2022; Mingoli,
   Andrea/A-2889-2010
OI D'ERMO, Giuseppe/0000-0003-4403-140X; Grande,
   Raffaele/0000-0003-2873-0104; Sapienza, Paolo/0000-0002-0198-7930;
   Brachini, Gioia/0000-0001-6724-5588; 
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   Sterpetti AV, 2011, ANN VASC SURG, V25, P766, DOI 10.1016/j.avsg.2011.01.006
   von Elm E, 2014, INT J SURG, V12, P1495, DOI [10.1016/j.ijsu.2014.07.013, 10.1186/s12905-019-0842-y]
   Yao M, 2014, INT WOUND J, V11, P483, DOI 10.1111/j.1742-481X.2012.01113.x
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NR 46
TC 4
Z9 4
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2020
VL 17
IS 1
BP 149
EP 157
DI 10.1111/iwj.13249
EA OCT 2019
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KC9VQ
UT WOS:000492670100001
PM 31657109
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Antoniou, GA
   Onwuka, CC
   Antoniou, SA
   Russell, D
AF Antoniou, George A.
   Onwuka, Collins C.
   Antoniou, Stavros A.
   Russell, David
TI Meta-analysis and trial sequential analysis of prophylactic negative
   pressure therapy for groin wounds in vascular surgery
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Review
DE Negative pressure therapy; Vacuum-assisted closure; Surgical site
   infection
ID SURGICAL SITE INFECTION; INCISION; RISK; COMPLICATIONS; PREVENTION
AB Background: Negative pressure therapy has been proposed as a prophylactic measure to promote surgical wound healing and reduce surgical site complications.
   Methods: We conducted a systematic review of the literature to identify randomized controlled trials (RCTs) comparing prophylactic negative pressure therapy with standard practice in closed groin incisions in vascular surgery. We calculated the pooled odds ratio (OR) or risk difference and 95% confidence interval (CI) with the use of the fixed-effect model. To control the risk of type I error, we adjusted the thresholds for the Z-values with the use of the O'Brien-Fleming a-spending function, and the risk of type II error was controlled with the use of the b-spending function and futility boundaries.
   Results: We selected six RCTs reporting on a total of 733 groin wounds. Patients with negative pressure wound therapy had a lower risk of developing surgical site infection (OR, 0.36; 95% CI, 0.24-0.54; P <.001), a lower risk of revision surgery (OR, 0.44; 95% CI, 0.22-0.88; P =.02) and a shorter hospital stay (weighted mean difference, -2.14; 95% CI, -3.78 to 0.49; P =.01). There was no difference in in-hospital mortality (risk difference, 0.01; 95% CI, -0.02 to 0.05; P =.53) or readmission (OR, 0.46; 95% CI, 0.17-1.29; P =.14). The Z-curve for surgical site infection crossed the O'Brien-Fleming significance boundaries for superiority (before the required information size was reached).
   Conclusions: Prophylactic negative pressure wound therapy confers improved outcomes in patients undergoing arterial surgery via a groin incision compared with standard surgical wound care.
C1 [Antoniou, George A.; Onwuka, Collins C.] Pennine Acute Hosp NHS Trust, Royal Oldham Hosp, Dept Vasc & Endovasc Surg, Manchester, Lancs, England.
   [Antoniou, George A.] Univ Manchester, Sch Med Sci, Div Cardiovasc Sci, Manchester, Lancs, England.
   [Antoniou, Stavros A.] European Univ Cyprus, Sch Med, Dept Surg, Nicosia, Cyprus.
   [Russell, David] Leeds Teaching Hosp NHS Trust, Leeds Gen Infirm, Leeds Vasc Inst, Leeds, W Yorkshire, England.
C3 University of Manchester; European University Cyprus; Leeds General
   Infirmary; University of Leeds
RP Antoniou, GA (通讯作者)，Royal Oldham Hosp, Phase 1,Rochdale Rd, Manchester OL1 2JH, Lancs, England.
EM georgios.antoniou@pat.nhs.uk
RI Antoniou, Stavros/I-6844-2019; Russell, David/IXN-3147-2023
OI Russell, David/0000-0002-1293-5618
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
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   DiMuzio P, 2017, J VASC SURG, V65, p133S, DOI 10.1016/j.jvs.2017.03.250
   Engelhardt M, 2018, INT WOUND J, V15, P327, DOI 10.1111/iwj.12848
   Fleming CA, 2018, J HOSP INFECT, V99, P75, DOI 10.1016/j.jhin.2017.10.022
   Gombert A, 2018, EUR J VASC ENDOVASC, V56, P442, DOI 10.1016/j.ejvs.2018.05.018
   Higgins J.P. T., 2011, COCHRANE HDB SYSTEMA
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   Inui T, 2015, SEMIN VASC SURG, V28, P201, DOI 10.1053/j.semvascsurg.2016.02.002
   Koetje JH, 2015, Surgery Research and Practice, V2015, P1, DOI [10.1155/2015/303560, 10.1155/2015/303560, DOI 10.1155/2015/303560]
   Kwon J, 2018, J VASC SURG, V68, P1744, DOI 10.1016/j.jvs.2018.05.224
   Lee K, 2017, J VASC SURG, V66, P1814, DOI 10.1016/j.jvs.2017.06.084
   Matatov T, 2013, J VASC SURG, V57, P791, DOI 10.1016/j.jvs.2012.09.037
   Pleger SP, 2018, INT WOUND J, V15, P75, DOI 10.1111/iwj.12836
   Sabat J, 2016, J VASC SURG, V63, p94S, DOI 10.1016/j.jvs.2016.03.099
   Scalise A, 2016, INT WOUND J, V13, P1260, DOI 10.1111/iwj.12492
   Smid MC, 2017, OBSTET GYNECOL, V130, P969, DOI 10.1097/AOG.0000000000002259
   Swanson EW, 2016, PLAST SURG-CHIR PLAS, V24, P113, DOI 10.1177/229255031602400207
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NR 21
TC 32
Z9 38
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD NOV
PY 2019
VL 70
IS 5
BP 1700
EP +
DI 10.1016/j.jvs.2019.01.083
PG 17
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA JH3OV
UT WOS:000492678100043
PM 31126768
OA Bronze
DA 2026-07-24
ER
PT J
AU Li, HZ
   Xu, XH
   Wang, DW
   Lin, YM
   Lin, N
   Lu, HD
AF Li, Hui-Zi
   Xu, Xiang-He
   Wang, Da-Wei
   Lin, Yi-Ming
   Lin, Nan
   Lu, Hua-Ding
TI Negative pressure wound therapy for surgical site infections: a
   systematic review and meta-analysis of randomized controlled trials
SO CLINICAL MICROBIOLOGY AND INFECTION
LA English
DT Review
DE Meta-analysis; Negative-pressure wound therapy; Randomized controlled
   trials; Surgical wound infection; Systematic review
ID VACUUM-ASSISTED CLOSURE; OBESE WOMEN; CESAREAN DELIVERY; OPEN FRACTURE;
   PRIMARY HIP; RISK-FACTOR; LOWER-LIMB; GUIDELINES; INCISION; QUALITY
AB Objectives: Previous studies showed the effectiveness of negative pressure wound therapy (NPWT) in preventing surgical site infections (SSIs), but current guidelines do not recommend its routine use for surgical wounds. The aim was to compare the effectiveness and safety of NPWT with standard surgical dressing or conventional therapy for preventing SSIs.
   Methods: Pubmed, Embase and the Cochrane Library were systematically searched on 10 April 2019. Also, we searched clinicaltrials.gov and references of relevant studies. Eligibility criteria were randomized controlled trials (RCTs) and adult surgical patients were included. The effectiveness of NPWT versus standard surgical dressing or conventional therapy was investigated. Relative risks (RRs) and mean differences (MDs) with 95% confidence intervals (CIs) were used to estimate the pooled effect of dichotomous outcomes and continuous outcomes respectively. The primary outcome was surgical site infections. The quality of included studies and the certainty of the evidence were assessed using the risk of bias tool and the GRADE approach.
   Results: A total of 45 RCTs with 6624 surgical patients were included. NPWT reduced SSIs (RR 0.58; 95% CI 0.49-0.69) and wound dehiscence(17 RCTs; RR 0.80; 95% CI 0.65-1.00). NPWT did not increase the risk of hematoma (9 RCTs; RR 0.91; 95% CI 0.40-2.07) and hospital readmission(9 RCTs; RR 0.77; 95% CI 0.52-1.12) or prolong length of hospital stay(15 RCTs; MD -0.38; 95% CI, -0.78 to 0.02). NPWT significantly increased the risk of all adverse event-related outcomes (10 RCTs; RR 3.21; 95% CI, 1.17-8.78). The level of certainty was identified as low for the primary outcome and very low for all the secondary outcomes.
   Conclusions: Compared with standard wound care, NPWT may reduce the risk of SSIs. We are uncertain whether NPWT reduces or increases the risk of wound dehiscence, haematoma, hospital readmission and all adverse event-related outcomes or if it shortens or prolongs length of hospital stay. (C) 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
C1 [Li, Hui-Zi; Xu, Xiang-He; Wang, Da-Wei; Lin, Yi-Ming; Lin, Nan; Lu, Hua-Ding] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Orthopaed, Zhuhai 519000, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Lu, HD (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 5, Dept Orthopaed, Zhuhai 519000, Guangdong, Peoples R China.
EM johnniehuading@163.com
RI Wang, Dawei/HGE-1446-2022
FU National Natural Science Foundation of China [81772384, 81572174]
FX This study was supported by grants from the National Natural Science
   Foundation of China (nos. 81772384 and 81572174). The funders had no
   role in the study design, data collection and analysis, decision to
   publish, or preparation of the manuscript. All the authors do not have
   conflict of interests to declare.
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NR 90
TC 46
Z9 53
U1 0
U2 16
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1198-743X
EI 1469-0691
J9 CLIN MICROBIOL INFEC
JI Clin. Microbiol. Infect.
PD NOV
PY 2019
VL 25
IS 11
BP 1328
EP 1338
DI 10.1016/j.cmi.2019.06.005
PG 11
WC Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Microbiology
GA JH3QX
UT WOS:000492683600007
PM 31220604
DA 2026-07-24
ER
PT J
AU von Beckerath, O
   Kanya, S
   Gäbel, G
   Kröger, K
   Juntermanns, B
AF von Beckerath, Olga
   Kanya, Susanne
   Gaebel, Gabor
   Kroeger, Knut
   Juntermanns, Benjamin
TI Use of maggot debridement therapy in hospitalised patients in Germany
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE debridement; foot ulcer; infection; maggots
ID EFFICACY; MULTICENTER; QUALITY; ULCERS; FOOT
AB Exact data regarding the clinical role of maggot debridement therapy (MDT) for wound care in a specific country are not available. Thus, we analysed the use of MDT in hospitalised patients in Germany. Detailed lists of all hospitalised cases treated with MDT in Germany for the years 2011 to 2016 were provided by the Federal Statistical Office as well as the lists of the 15 most frequent principal and additional diagnoses, respectively, and the 10 most frequent procedures documented with MDT in 2016. Within the 6-year time period of the study, the number of cases treated with MDT increased by 11% from 4513 in 2011 to 5.017 in 2016. Lower leg and foot were the most frequent anatomic sides of treatment counting up to 83.9% of all cases. In addition, MDT procedures for temporary soft tissue coverage including negative pressure wound therapy were often performed: for treatment of large areas in 36.7% and small areas in 6.2%. 41.3% of all cases treated with MDT had infection with Escherichia coli and 35.9% of all cases with Bacillus fragilis. Our analysis shows a limited use of MDT with a small increase only in the last 6 years in German hospitals. MDT is predominately used to treat foot or leg ulcers.
C1 [von Beckerath, Olga; Gaebel, Gabor; Kroeger, Knut; Juntermanns, Benjamin] Helios Klin Krefeld, Dept Vasc Med, Krefeld, Germany.
   [Kanya, Susanne] Wound Healing, Krefeld, Germany.
C3 Helios Kliniken
RP Kröger, K (通讯作者)，HELIOS Klinikum Krefeld GmbH, Klin Gefassmed, Lutherpl 40, D-47805 Krefeld, Germany.
EM knut.kroeger@helios-kliniken.de
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NR 17
TC 8
Z9 9
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2020
VL 17
IS 1
BP 10
EP 15
DI 10.1111/iwj.13204
EA NOV 2019
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KC9VQ
UT WOS:000493722500001
PM 31680434
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Kim, JH
   Lee, DH
AF Kim, Jun-Ho
   Lee, Dae-Hee
TI Negative pressure wound therapy vs. conventional management in open
   tibia fractures: Systematic review and meta-analysis
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE Negative pressure wound therapy; Conventional wound management; Open
   tibia fractures; Systematic review; Meta-analysis
ID LOWER-LIMB; VACUUM; INFECTION; CLOSURE; FLAP; COVERAGE; OUTCOMES; RISK
AB Background: Severe open tibia fractures are disastrous injuries associated with a high incidence of complications. Negative pressure wound therapy (NPWT) is a novel treatment for open tibia fractures; however, its efficacy remains unclear. This is a systematic review and meta-analysis performed to evaluate the effect of NPWT on decreasing the infection rate, amputation rate, nonunion rate, and flap-related complications in open tibia fractures.
   Methods: The MEDLINE, EMBASE, and Cochrane Library databases were systematically searched. Complications were evaluated in terms of the rates of infection, amputation, nonunion, and flap-related complications.
   Results: Twelve studies were included. In the meta-analysis, NPWT showed significantly lower soft-tissue infection rate (odds ratio [OR] 0.48, 95% confidence interval [CI] 0.34-0.68, P < 0.0001), nonunion rate (OR 0.61, 95% CI 0.39-0.95, P = 0.03), flap necrosis rate (OR 0.37, 95% CI 0.21-0.63, P = 0.0003), and flap revision rate (OR 0.44, 95% CI 0.22-0.89, P = 0.02) than conventional wound management. However, no significant difference was found in osteomyelitis rate (OR 0.54, 95% CI 0.09-3.28, P = 0.50) and amputation rate (OR 0.89, 95% CI 0.36-2.22, P = 0.80) between the 2 groups.
   Conclusion: Lower rates of soft-tissue infection, nonunion, flap necrosis, and flap revision were observed in the NPWT group than in the conventional dressing group. However, additional high-quality studies are warranted to verify the efficacy of NPWT in the treatment of severe open tibia fractures. We could not make a definitive conclusion about the comparative efficacy of the 2 methods in terms of complications because of insufficient data. (C) 2019 Elsevier Ltd. All rights reserved.
C1 [Kim, Jun-Ho; Lee, Dae-Hee] Sungkyunkwan Univ, Samsung Med Ctr, Dept Orthopaed Surg, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Lee, DH (通讯作者)，Sungkyunkwan Univ, Samsung Med Ctr, Dept Orthopaed Surg, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea.
EM junojuno49@gmail.com; eoak22@empal.com
RI Lee, Dae-Hee/I-9390-2017
OI Lee, Dae-Hee/0000-0003-3147-8763
FU SMC-Ottogi Research Fund [SMX1162171]
FX This study was supported by SMC-Ottogi Research Fund (SMX1162171).
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NR 30
TC 26
Z9 36
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD OCT
PY 2019
VL 50
IS 10
BP 1764
EP 1772
DI 10.1016/j.injury.2019.04.018
PG 9
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA JJ2FC
UT WOS:000493975800026
PM 31047682
DA 2026-07-24
ER
PT J
AU Petrou, S
   Parker, B
   Masters, J
   Achten, J
   Bruce, J
   Lamb, SE
   Parsons, N
   Costa, ML
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   Griffin, D
   Jeffery, S
   Arrowsmith, J
   Datta, G
   Dennison, M
   Farrar, M
   Giannoudis, P
   Gray, A
   Henman, P
   Hull, P
   Khan, U
   Lewis, C
   Loveday, D
   Mangwani, J
   McAndrew, A
   McClelland, D
   McNicholas, M
   Noyes, D
   Ollivere, B
   Pallister, I
   Porter, K
   Ramachandran, M
   Rickard, R
   Rogers, B
   Sharma, H
   Tavakkolizadeh, M
   Young, J
AF Petrou, S.
   Parker, B.
   Masters, J.
   Achten, J.
   Bruce, J.
   Lamb, S. E.
   Parsons, N.
   Costa, M. L.
   Willett, Keith
   Griffin, Damian
   Jeffery, Steven
   Arrowsmith, Jill
   Datta, Gorav
   Dennison, Mick
   Farrar, Mark
   Giannoudis, Peter
   Gray, Andrew
   Henman, Philip
   Hull, Peter
   Khan, Umraz
   Lewis, Charlotte
   Loveday, David
   Mangwani, Jitendra
   McAndrew, Andrew
   McClelland, Damian
   McNicholas, Mike
   Noyes, David
   Ollivere, Ben
   Pallister, Ian
   Porter, Keith
   Ramachandran, Manoj
   Rickard, Rory
   Rogers, Benedict
   Sharma, Hemant
   Tavakkolizadeh, Mel
   Young, Jonathan
CA WOLLF Trial Collaborators
TI Cost-effectiveness of negative-pressure wound therapy in adults with
   severe open fractures of the lower limb: evidence from the WOLLF
   randomized controlled trial
SO BONE & JOINT JOURNAL
LA English
DT Article
ID HEALTH; INFECTION; DISABILITY; EUROQOL
AB Aims
   The aim of this study was to estimate the cost-effectiveness of negative-pressure wound therapy (NPWT) in comparison with standard wound management after initial surgical wound debridement in adults with severe open fractures of the lower limb.
   Patients and Methods
   An economic evaluation was conducted from the perspective of the United Kingdom NHS and Personal Social Services, based on evidence from the 460 participants in the Wound Management of Open Lower Limb Fractures (WOLLF) trial. Economic outcomes were collected prospectively over the 12-month follow-up period using trial case report forms and participant-completed questionnaires. Bivariate regression of costs (given in  pound, 2014 to 2015 prices) and quality-adjusted life-years (QALYs), with multiple imputation of missing data, was conducted to estimate the incremental cost per QALY gained associated with NPWT dressings. Sensitivity and subgroup analyses were undertaken to assess the impacts of uncertainty and heterogeneity, respectively, surrounding aspects of the economic evaluation.
   Results
   The base case analysis produced an incremental cost-effectiveness ratio of 267 pound 910 per QALY gained, reflecting higher costs on average (678; pound 95% confidence interval (CI) -1082 pound to 2438) pound and only marginally higher QALYS (0.002; 95% CI -0.054 to 0.059) in the NPWT group. The probability that NPWT is cost-effective in this patient population did not exceed 27% regardless of the value of the cost-effectiveness threshold. This result remained robust to several sensitivity and subgroup analyses.
   Conclusion
   This trial-based economic evaluation suggests that NPWT is unlikely to be a cost-effective strategy for improving outcomes in adult patients with severe open fractures of the lower limb.
C1 [Petrou, S.; Parker, B.] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Hlth Econ, Gibbet Hill Campus, Coventry, W Midlands, England.
   [Bruce, J.] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Clin Trials, Gibbet Hill Campus, Coventry, W Midlands, England.
   [Masters, J.] Univ Warwick, Coventry, W Midlands, England.
   [Achten, J.] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Gibbet Hill Campus, Coventry, W Midlands, England.
   [Lamb, S. E.] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Trauma & Rehabil, Gibbet Hill Campus, Coventry, W Midlands, England.
   [Parsons, N.] Univ Warwick, Warwick Med Sch, Stat & Epidemiol Unit, Gibbet Hill Campus, Coventry, W Midlands, England.
   [Costa, M. L.] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Orthopaed Trauma, Gibbet Hill Campus, Coventry, W Midlands, England.
   [Petrou, S.] Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England.
   [Masters, J.; Lamb, S. E.; Costa, M. L.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
   [Costa, M. L.] Univ Hosp Coventry & Warwickshire NHS Trust, Clifford Bridge Rd, Coventry, W Midlands, England.
C3 University of Warwick; University of Warwick; University of Warwick;
   University of Warwick; University of Warwick; University of Warwick;
   University of Warwick; University of Oxford; University of Oxford;
   University of Warwick
RP Petrou, S (通讯作者)，Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Hlth Econ, Gibbet Hill Campus, Coventry, W Midlands, England.; Petrou, S (通讯作者)，Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England.
EM stavros.petrou@phc.ox.ac.uk
RI ; Parsons, Nick/AAA-8713-2019; Petrou, Stavros/ABD-8323-2021; Bruce,
   Julie/G-7588-2014; Achten, Juul/KUD-8515-2024; Masters,
   James/U-8764-2019; /A-5207-2013; Giannoudis, Peter/AAA-3617-2020;
   Arrowsmith, Jill/LTY-6777-2024
OI Costa, Matthew/0000-0003-3644-1388; Parsons, Nick/0000-0001-9975-888X;
   Petrou, Stavros/0000-0003-3121-6050; Bruce, Julie/0000-0002-8462-7999;
   Loveday, David/0000-0002-6383-2037; Griffin, Damian/0000-0003-0952-7848;
   Lamb, Sarah/0000-0003-4349-7195; Achten, Juul/0000-0002-8857-5743;
   Ollivere, Benjamin/0000-0002-1410-1756; Masters,
   James/0000-0001-9663-8858; Mangwani, Jitendra/0000-0002-3960-3023; 
FU UK National Institute for Health Research (NIHR) Health Technology
   Assessment (HTA) [10/57/20]; European Union (EU); Royal College of
   Surgeons England and Industry; NIHR; National Institute for Health
   Research [NF-SI-0616-10103, 10/57/20] Funding Source: researchfish; The
   Dunhill Medical Trust [DMT/RCS605] Funding Source: researchfish
FX S. Petrou, J. Achten, J. Bruce, S. E. Lamb, N. Parsons, and M. L. Costa
   report an institutional grant (paid to The University of Warwick) from
   the UK National Institute for Health Research (NIHR) Health Technology
   Assessment (HTA) Programme (project number 10/57/20), related to this
   study. M. L. Costa is also employed by the University of Oxford, which
   received institutional research fund grants from the NIHR, the European
   Union (EU), and the Royal College of Surgeons England and Industry.
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NR 40
TC 24
Z9 26
U1 0
U2 9
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD NOV
PY 2019
VL 101B
IS 11
BP 1392
EP 1401
DI 10.1302/0301-620X.101B11.BJJ-2018-1228.R2
PG 10
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Orthopedics; Surgery
GA JJ2MN
UT WOS:000493996400010
PM 31674241
DA 2026-07-24
ER
PT J
AU Jiménez-Fuertes, M
   García-Olmo, DC
   Puy, S
   Beisani, M
   Planells, F
   Boldó, A
   Ruiz-Tovar, J
   Durán, M
   García-Olmo, D
AF Jimenez-Fuertes, Montiel
   Garcia-Olmo, Dolores C.
   Puy, Sara
   Beisani, Marc
   Planells, Francisca
   Boldo, Alba
   Ruiz-Tovar, Jaime
   Duran, Manuel
   Garcia-Olmo, Damian
TI Effects of negative-pressure therapy with and without ropivacaine
   instillation in the early evolution of severe peritonitis in pigs
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Sepsis; Peritonitis; Temporary abdominal closure; Negative-pressure
   therapy; Instillation; Septic open abdomen
ID VACUUM-ASSISTED CLOSURE; INTRAABDOMINAL HYPERTENSION; INFLAMMATION;
   LIDOCAINE; CYTOKINES; SEPSIS; INJURY; FLUID; RATS
AB Purpose The abdomen is the second most common source of sepsis and secondary peritonitis, which likely lead to death. In the present study, we hypothesized that instillation of local anesthetics into the peritoneum might mitigate the systemic inflammatory response syndrome (SIRS) in the open abdomen when combined with negative-pressure therapy (NPT) to treat severe peritonitis. Methods We performed a study in 21 pigs applying a model of sepsis based on ischemia/reperfusion and fecal spread into the peritoneum. The pigs were randomized into three groups, and treated for 6 h as follows: Group A: temporary abdominal closure with ABTHERA (TM) Open Abdomen Negative-Pressure Therapy; Group B: temporary abdominal closure with ABTHERA (TM) Open Abdomen Negative-Pressure Therapy plus abdominal instillation with physiological saline solution (PSS); and Group C: temporary abdominal closure with ABTHERA (TM) Open Abdomen Negative-Pressure Therapy plus peritoneal instillation with a solution of ropivacaine in PPS. Results A comparison between the three groups revealed no statistically significant difference for any of the parameters registered (p > 0.05), i.e., intra-abdominal pressure, blood pressure, heart rate, O-2 saturation, diuresis, body temperature, and blood levels of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF alpha), and c-reactive protein (CRP). In addition, histological studies of the liver, ileum, kidney and lung showed no difference between groups. Conclusions The use of abdominal instillation (with or without ropivacaine) did not change the effect of 6 h of NPT after sepsis in animals with open abdomen. The absence of adverse effects suggests that longer treatments should be tested.
C1 [Jimenez-Fuertes, Montiel; Ruiz-Tovar, Jaime; Duran, Manuel] Rey Juan Carlos Univ Hosp, Fdn Jimenez Diaz IIS FJD, Madrid, Spain.
   [Jimenez-Fuertes, Montiel; Ruiz-Tovar, Jaime; Duran, Manuel] Inst Invest Sanitaria, Madrid, Spain.
   [Garcia-Olmo, Dolores C.; Puy, Sara; Beisani, Marc; Planells, Francisca; Boldo, Alba] IRBLleida, CREBA, Lleida, Spain.
   [Beisani, Marc] Hosp Mar, Dept Surg, Barcelona, Spain.
   [Garcia-Olmo, Damian] Univ Hosp, Fdn Jimenez Diaz, Dept Gen & Digest Surg, Madrid, Spain.
   [Garcia-Olmo, Damian] Inst Invest Sanitaria IIS FJD, Madrid, Spain.
C3 Fundacion Jimenez Diaz; Hospital del Mar Research Institute; Hospital
   del Mar; Fundacion Jimenez Diaz; Fundacion Jimenez Diaz
RP Jiménez-Fuertes, M (通讯作者)，Rey Juan Carlos Univ Hosp, Fdn Jimenez Diaz IIS FJD, Madrid, Spain.; Jiménez-Fuertes, M (通讯作者)，Inst Invest Sanitaria, Madrid, Spain.
EM montiel.jf77@gmail.com
RI ; Duran-Poveda, Manuel/AAS-6519-2021; Garcia Olmo, Damian/L-5733-2014
OI Jimenez Fuertes, Montiel/0009-0002-3836-0944; Garcia Olmo,
   Damian/0000-0002-9369-2338; Beisani, Marc/0000-0002-3773-5209;
   Duran-Poveda, Manuel/0000-0002-4335-7208; Garcia Olmo,
   Damian/0000-0002-9369-2338
FU Acelity/KCI, San Antonio, TX, USA
FX This research received a specific grant from Acelity/KCI, San Antonio,
   TX, USA.
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NR 31
TC 1
Z9 1
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD APR
PY 2021
VL 47
IS 2
SI SI
BP 597
EP 606
DI 10.1007/s00068-019-01244-9
EA OCT 2019
PG 10
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA RH0SL
UT WOS:000494196300002
PM 31641785
DA 2026-07-24
ER
PT J
AU Lin, FY
   Huang, PY
   Cheng, HT
AF Lin, Fu-Yu
   Huang, Pin-Yi
   Cheng, Hsu-Tang
TI Systematic review of negative pressure wound therapy for head and neck
   wounds with fistulas: Outcomes and complications
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE fistula; head and neck reconstruction; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; RECONSTRUCTION
AB Fistula formation in head and neck wounds is considered one of the most challenging complications that a head and neck reconstructive surgeon may encounter. The current mainstay of treatment is aggressive surgical debridement followed by vascularised soft tissue coverage. Negative pressure wound therapy (NPWT) has been successfully used for the closure of complicated wounds for decades. This study analysed the outcomes and complications of NPWT in the management of head and neck wounds with fistulas. A systematic search of studies published between January 1966 and September 2019 was conducted using the PubMed, MEDLINE, EMBASE, and SCOPUS databases and using the following key words: "negative pressure wound therapy," "head and neck," and "fistula." We included human studies with abstract and full text available. Analysed endpoints were rate of fistula closure, follow-up duration, and complications if present. Nine retrospective case series (Level IV evidence) that collectively included 122 head and neck wounds with orocutaneous fistulas, pharyngocutaneous fistulas, and salivary contamination were examined. The number of patients included in each study ranged from 5 to 64. The mode of NPWT varied among the included studies, with most adopting a continuous pressure of -125 mm Hg. Mean durations of NPWT ranged from 3.7 to 23 days, and the reported fistula closure rate ranged from 78% to 100%. To achieve complete wound healing, six studies used additional procedures after stopping NPWT, including conventional wound dressings and vascularised tissue transfer. Information regarding follow up was provided in only three of the nine studies, where patients were followed for 5, 10, and 18 months. No serious adverse events were reported. NPWT for head and neck wounds with fistulas may be considered a safe treatment method that yields beneficial outcomes with a low risk of complications. The current data originated mainly from studies with low levels of evidence characterised by heterogeneity. Therefore, definitive recommendations based on these data cannot be offered. Additional high-quality trials are warranted to corroborate the findings of this systematic review.
C1 [Lin, Fu-Yu; Huang, Pin-Yi] China Med Univ, Dept Med Educ, China Med Univ Hosp, Sch Med, Taichung, Taiwan.
   [Lin, Fu-Yu; Huang, Pin-Yi] China Med Univ, Dept Neurol, China Med Univ Hosp, Sch Med, Taichung, Taiwan.
   [Cheng, Hsu-Tang] Asia Univ, Coll Med & Hlth Sci, Asia Univ Hosp, Div Plast & Reconstruct Surg,Dept Surg, 222 Fuxin Rd, Taichung 41354, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; Asia University Taiwan
RP Cheng, HT (通讯作者)，Asia Univ, Coll Med & Hlth Sci, Asia Univ Hosp, Div Plast & Reconstruct Surg,Dept Surg, 222 Fuxin Rd, Taichung 41354, Taiwan.
EM hsutangcheng@gmail.com
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NR 30
TC 7
Z9 13
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2020
VL 17
IS 2
BP 251
EP 258
DI 10.1111/iwj.13264
EA NOV 2019
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KR3MH
UT WOS:000494631200001
PM 31696637
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Donlon, NE
   Boland, PA
   Kelly, ME
   Schmidt, K
   Cooke, F
   Neary, PM
   Barry, KM
   Reynolds, JV
AF Donlon, Noel Edward
   Boland, P. A.
   Kelly, M. E.
   Schmidt, K.
   Cooke, F.
   Neary, P. M.
   Barry, K. M.
   Reynolds, J. V.
TI Prophylactic negative wound therapy in laparotomy wounds (PROPEL trial):
   randomized controlled trial
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Emergency surgery; Surgical site infection; Wound management; Negative
   pressure wound therapy
ID SURGICAL SITE INFECTION; PRESSURE; CLOSURE; PREVENTION; SURGERY;
   MANAGEMENT; PATIENT; SCARS
AB Background Superficial surgical site infections are a common post-operative complication. They also place a considerable financial burden on healthcare. The use of prophylactic negative pressure wound therapy has been advocated to reduce wound infection rates. However, there is debate around its routine use. The purpose of this trial is to determine if prophylactic negative pressure wound therapy reduces post-operative wound complications in patients undergoing laparotomy. Methods/design This multi-centre randomised controlled trial will compare standard surgical dressings (control) to two competing negative pressure wound therapy dressings (Prevena (TM) and PICO (TM)). All patients will be over 18 years, who are undergoing an emergency or elective laparotomy. It is intended to enrol a total of 271 patients for the trial. Discussion The PROPEL trial is a multi-centre randomised controlled trial of patients undergoing laparotomy. The comparison of standard treatment to two commercially available NPWT will help provide consensus on the routine management of laparotomy wounds.
C1 [Donlon, Noel Edward; Boland, P. A.; Kelly, M. E.; Reynolds, J. V.] St James Hosp, Dept Surg, Dublin 8, Ireland.
   [Schmidt, K.] Wexford Gen Hosp, Dept Surg, Wexford, Ireland.
   [Cooke, F.; Neary, P. M.] Univ Hosp Waterford, Dept Surg, Waterford, Ireland.
   [Barry, K. M.] Mayo Univ Hosp, Dept Surg, Mayo, Ireland.
C3 Trinity College Dublin
RP Donlon, NE (通讯作者)，St James Hosp, Dept Surg, Dublin 8, Ireland.
EM donlonn@tcd.ie
RI ; Kelly, Michael E/AAF-1917-2021
OI Boland, Patrick/0000-0002-5844-7695; Kelly, Michael
   E/0000-0002-0757-6411
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NR 47
TC 11
Z9 12
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD NOV
PY 2019
VL 34
IS 11
BP 2003
EP 2010
DI 10.1007/s00384-019-03398-9
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA JL0QZ
UT WOS:000495241500021
PM 31529194
DA 2026-07-24
ER
PT J
AU Brillantino, A
   Andreano, M
   Lanza, M
   D'Ambrosio, V
   Fusco, F
   Antropoli, M
   Lucia, A
   Zito, ES
   Forner, A
   Ambrosino, F
   Monte, G
   Cricri, AM
   Robustelli, U
   De Masi, A
   Calce, R
   Ciardiello, G
   Renzi, A
   Castriconi, M
AF Brillantino, Antonio
   Andreano, Mauro
   Lanza, Michele
   D'Ambrosio, Vito
   Fusco, Ferdinando
   Antropoli, Massimo
   Lucia, Antonella
   Zito, Enzo Saverio
   Forner, Anna
   Ambrosino, Francesco
   Monte, Giovanni
   Cricri, Antonio Maria
   Robustelli, Umberto
   De Masi, Alessandro
   Calce, Rosario
   Ciardiello, Giovanna
   Renzi, Adolfo
   Castriconi, Maurizio
TI Advantages of Damage Control Strategy With Abdominal Negative Pressure
   and Instillation in Patients With Diffuse Peritonitis From Perforated
   Diverticular Disease
SO SURGICAL INNOVATION
LA English
DT Article
DE diverticulitis; perforated diverticular disease; peritonitis; damage
   control surgery; open abdomen; Hartmann's procedure
ID INTERNATIONAL CONSENSUS DEFINITIONS; WOUND THERAPY; SEPSIS; GUIDELINES;
   MANAGEMENT; SURGERY
AB Purpose. To evaluate the results of Damage Control Strategy (DCS) in the treatment of generalized peritonitis from perforated diverticular disease in patients with preoperative severe systemic diseases. Methods. All the patients with diffuse peritonitis (Hinchey 3 and 4) and the American Society of Anesthesiologists (ASA) score >= 3 were included and underwent DCS consisting of a 2-step procedure. The first was peritoneal lavage, perforated colon-stapled resection, and temporary abdominal closure with negative pressure wound therapy combined with instillation. The second step, 48 hours later, included the possibility of restoring intestinal continuity basing on local and general patients' conditions. Results. Thirty patients (18 [60%] women and 12 [40%] men, median age 68.5 [range = 35-84] years) were included (18 [60%] ASA III, 11 [36.7%] ASA IV, and 1 [0.03%] ASA V). Seven patients (23.3%) showed sepsis and 1 (3.33%) septic shock. At second surgery, 24 patients (80%) received a colorectal anastomosis and 6 patients (20%) underwent a Hartmann's procedure. Median hospital stay was 18 days (range = 12-62). Postoperative morbidity rate was 23.3% (7/30) and included 1 anastomotic leak treated with Hartmann's procedure. Consequently, at discharge from hospital, 23 patients (76.6%) were free of stoma. Primary fascial closure was possible in all patients. Conclusions. DCS with temporary abdominal closure by negative pressure wound therapy combined with instillation in patients with diffuse peritonitis from complicated diverticulitis could represent a feasible surgical option both in hemodynamically stable and no stable patients, showing encouraging results including a low stoma rate and an acceptable morbidity rate.
C1 [Brillantino, Antonio; Andreano, Mauro; Lanza, Michele; D'Ambrosio, Vito; Fusco, Ferdinando; Antropoli, Massimo; Lucia, Antonella; Zito, Enzo Saverio; Forner, Anna; Ambrosino, Francesco; Monte, Giovanni; Cricri, Antonio Maria; Robustelli, Umberto; De Masi, Alessandro; Calce, Rosario; Ciardiello, Giovanna; Castriconi, Maurizio] A Cardarelli Hosp, Via A Cardarelli 9, I-80131 Naples, Italy.
   [Renzi, Adolfo] Villa delle Querce Hosp, Naples, Italy.
C3 Antonio Cardarelli Hospital
RP Brillantino, A (通讯作者)，A Cardarelli Hosp, Via A Cardarelli 9, I-80131 Naples, Italy.
EM antonio.brillantino@gmail.com
RI ; Renzi, Adolfo/AAL-7610-2020; Del Monte, Giovanni/LCD-2405-2024
OI Brillantino, Antonio/0000-0002-0198-8511; Renzi,
   Adolfo/0000-0002-6629-6057; 
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NR 31
TC 18
Z9 19
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD DEC
PY 2019
VL 26
IS 6
BP 656
EP 661
DI 10.1177/1553350619857561
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JL1RQ
UT WOS:000495310800002
PM 31221028
DA 2026-07-24
ER
PT J
AU Wang, L
   Xu, X
   Cao, JG
   Liu, J
AF Wang, Lei
   Xu, Xin
   Cao, Jian-gang
   Liu, Jun
TI Negative pressure wound therapy in total hip and knee arthroplasty: a
   meta-analysis
SO JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
LA English
DT Article
DE arthroplasty; hip; knee; negative pressure; wound
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; REVISION HIP;
   RISK-FACTORS; DRESSINGS; INCISION; MANAGEMENT; SURGERY; COMPLICATIONS
AB Aim: To assess the efficiency and safety of negative pressure wound therapy (NPWT) in the total hip and knee arthroplasty, we conducted a meta-analysis from randomized controlled trials. Methods: Potential academic articles were identified from the Cochrane Library, PubMed, Embase, Springer and ScienceDirect. Secondary sources were identified from the references of the included literature. RevMan 5.1 was used to analyze the pooled data. Results: Six randomized controlled trials met the inclusion criteria. Meta-analysis showed more superficial surgical site infection and blisters in patients with total knee arthroplasty. There were no significant differences between two groups in total infection and total complications. Conclusion: NPWT decreased the incidence of superficial surgical site infection. More blisters were noticed in patients with NPWT after total knee arthroplasty.
C1 [Wang, Lei; Liu, Jun] Tianjin Hosp, Dept Joint Surg, Tianjin 300211, Peoples R China.
   [Xu, Xin] Nankai Hosp, Tianjin Hosp ITCWM, Dept Imaging, Tianjin 300100, Peoples R China.
   [Cao, Jian-gang] Tianjin Hosp, Dept Sport Med, Tianjin 300211, Peoples R China.
C3 Tianjin University; Tianjin University
RP Liu, J (通讯作者)，Tianjin Hosp, Dept Joint Surg, Tianjin 300211, Peoples R China.
EM tjyydrliu@126.com
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NR 23
TC 5
Z9 6
U1 0
U2 7
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 2042-6305
EI 2042-6313
J9 J COMP EFFECT RES
JI J. Comp. Eff. Res.
PD JUL
PY 2019
VL 8
IS 10
BP 791
EP 797
DI 10.2217/cer-2019-0009
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA JM9XL
UT WOS:000496558800005
PM 31397173
DA 2026-07-24
ER
PT J
AU Moffatt, CJ
   Murray, S
   Aubeeluck, A
   Quere, I
AF Moffatt, Christine J.
   Murray, Susie
   Aubeeluck, Aimee
   Quere, Isabelle
TI Communication with patients using negative wound pressure therapy and
   their adherence to treatment
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE adherence; communication; concordance; medical devices; negative
   pressure wound therapy
ID COMPRESSION THERAPY; LEG ULCERS; PART 2; IMPACT; RECURRENCE; EXPERIENCE;
   EDUCATION; BARRIERS; OUTCOMES; PEOPLE
AB Objective: The purpose of this study was to explore the challenges of communication between patients and health professionals, and patient adherence to treatment for hard-to-heal wounds when using negative wound pressure therapy (NPWT).
   Methods: Face-to-face, semi-structured interviews were conducted with patients undergoing NPWT. Specific features of the NPWT device were the priority for discussion although other factors central to communication and adherence were also explored.
   Results: A total of 24 patients took part in the study. Data saturation was achieved during the analysis. Patients required ongoing support to understand complex and often protracted treatment and this was particularly important when specialist technology was used. A distinction was highlighted between those who decided not to adhere with therapy and those who did so unintentionally. Participants faced difficulties in their communications with health professionals and in ensuring their needs were listened to and addressed.
   Conclusion: Further research is needed to achieve a better understanding of this distinction and to evaluate interventions which can sustain adherence behaviours. Further exploration of how to establish concordant patient/health professional communications is warranted.
C1 [Moffatt, Christine J.] Nottingham Trent Univ, Nottingham, England.
   [Moffatt, Christine J.; Quere, Isabelle] Univ Montpellier I, CHU Eloi, EA2992, Montpellier Med Vasc, Montpellier, France.
   [Murray, Susie] CRICP, London, England.
   [Aubeeluck, Aimee] Univ Nottingham, Nottingham, England.
C3 Nottingham Trent University; Universite de Montpellier; CHU de
   Montpellier; University of Nottingham
RP Moffatt, CJ (通讯作者)，Nottingham Trent Univ, Nottingham, England.; Moffatt, CJ (通讯作者)，Univ Montpellier I, CHU Eloi, EA2992, Montpellier Med Vasc, Montpellier, France.
EM Christine.Moffatt@ntu.ac.uk
RI ; Quere, Isabelle/AAB-8519-2020; aubeeluck, aimee/B-9782-2008
OI Moffatt, Christine/0000-0002-2436-0129; Quere,
   Isabelle/0000-0002-1492-9764; aubeeluck, aimee/0000-0003-3388-049X
FU Smith&Nephew Healthcare
FX The work was supported by a research grant from Smith&Nephew Healthcare.
   Smith&Nephew were not involved in the analysis or writing of this paper.
   There are no conflicts of interest to declare.
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NR 55
TC 6
Z9 7
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2019
VL 28
IS 11
BP 738
EP 756
DI 10.12968/jowc.2019.28.11.738
PG 16
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA JM9YA
UT WOS:000496560300006
PM 31721670
DA 2026-07-24
ER
PT J
AU Gupta, A
   Gupta, A
   Ravi, B
   Mundra, M
   Sandhu, H
   Agrawal, S
   Anjum, R
AF Gupta, Ashish
   Gupta, Amit
   Ravi, Bina
   Mundra, Mukund
   Sandhu, Harindra
   Agrawal, Saumya
   Anjum, Rohik
TI Post-traumatic necrotising fasciitis of the breast: a case study with
   literature review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE breast; necrotising fasciitis; negative pressure wound therapy
ID SOFT-TISSUE INFECTION; RARE
AB Necrotising fasciitis is a rare infection of the skin and underlying soft tissue. It primarily involves the extremities and rarely the breast. Primary necrotising fasciitis of the breast in a non-lactating, healthy female is rarer still. The authors present the case report of a patient presenting with primary necrotising fasciitis of the breast after sustaining a penetrating injury. The patient was managed successfully with serial debridement and negative pressure wound therapy (NPWT). To our knowledge only 19 such cases have been reported in the indexed literature so far. This is also the eighth case globally of primary necrotising fasciitis of the breast in a non-lactating female without any associated immunosuppression, which is the basis of reporting this case.
C1 [Gupta, Ashish; Gupta, Amit; Ravi, Bina; Mundra, Mukund; Sandhu, Harindra; Agrawal, Saumya; Anjum, Rohik] AIIMS, Dept Gen Surg, Rishikesh 249203, India.
C3 All India Institute of Medical Sciences (AIIMS) Rishikesh
RP Gupta, A (通讯作者)，AIIMS, Dept Gen Surg, Rishikesh 249203, India.
EM Drashish0403@gmail.com
RI Gupta, Amit/AAH-6340-2019
OI Anjum T Siddeek, Rohik/0000-0002-6106-2630; RAVI,
   BINA/0000-0001-8894-6674; GUPTA, AMIT KUMAR/0009-0008-9033-6080
CR Anaya DA, 2007, CLIN INFECT DIS, V44, P705, DOI 10.1086/511638
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NR 31
TC 8
Z9 11
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2019
VL 28
IS 11
BP 775
EP 778
DI 10.12968/jowc.2019.28.11.775
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA JM9YA
UT WOS:000496560300009
PM 31721667
DA 2026-07-24
ER
PT J
AU Hohendorff, J
   Drozdz, A
   Borys, S
   Ludwig-Slomczynska, AH
   Kiec-Wilk, B
   Stepien, EL
   Malecki, MT
AF Hohendorff, Jerzy
   Drozdz, Anna
   Borys, Sebastian
   Ludwig-Slomczynska, Agnieszka H.
   Kiec-Wilk, Beata
   Stepien, Ewa L.
   Malecki, Maciej T.
TI Effects of Negative Pressure Wound Therapy on Levels of Angiopoetin-2
   and Other Selected Circulating Signaling Molecules in Patients with
   Diabetic Foot Ulcer
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID ANGIOPOIETIN-2; MICROPARTICLES; CELLS; MICROVESICLES; VESICLES;
   AMPUTATION; SURVIVAL; ENHANCE; GROWTH; VEGF
AB Background and Aims. Diabetic foot ulcers (DFUs) are linked to amputations and premature deaths. Negative pressure wound therapy (NPWT) has been used for DFUs. The mechanism of NPWT's action may be associated with its influence on circulating molecules. We assessed NPWT's effect on the plasma levels of angiopoietin-2 (Ang2), a key regulator of angiogenesis, and its microvesicular receptors (Tie2) as well as the microvesicles (MVs) themselves in DFU patients. Materials and Methods. We included 69 patients with type 2 diabetes mellitus (T2DM) and neuropathic, noninfected DFUs-49 were treated with NPWT and 20 were treated with standard therapy (ST). Assigning patients to the NPWT group was not random but based on DFU characteristics, especially wound area. Ang2 was measured by ELISA in the entire group, while in a subgroup of 19 individuals on NPWT and 10 on ST, flow cytometry was used to measure Tie2+ and the corresponding isotype control (Iso+) and annexin V (AnnV+) as well as total MVs. Measurements were performed at the beginning and after 8 +/- 1 days of therapy. Results. Treatment groups were similar for basic characteristics but differed by their median DFU areas (10.3 (4.2-18.9) vs. 1.3 (0.9-3.4) cm(2), p=0.0001). At day 0, no difference was observed in Ang2 levels, total MVs, MV Tie+, and MV AnnV+ between the groups. Ang2 decreased after 8 days in the NPWT group, unlike in the ST group (3.54 (2.40-5.40) vs. 3.32 (2.33-4.61), p=0.02, and 3.19 +/- 1.11 vs. 3.19 +/- 1.29 ng/mL, p=0.98, respectively). No other parameters were identified that may have been influenced by the NPWT treatment. Conclusion. NPWT in T2DM patients with neuropathic, noninfected DFU seems to lead to reduction of the Ang2 level. Influencing the level of Ang2 may constitute one of NPWT-related mechanisms to accelerate wound healing.
C1 [Hohendorff, Jerzy; Borys, Sebastian; Kiec-Wilk, Beata; Malecki, Maciej T.] Jagiellonian Univ, Dept Metab Dis, Med Coll, Krakow, Poland.
   [Hohendorff, Jerzy; Borys, Sebastian; Kiec-Wilk, Beata; Malecki, Maciej T.] Univ Hosp, Clin Metab Dis, Krakow, Poland.
   [Drozdz, Anna; Stepien, Ewa L.] Jagiellonian Univ, Marian Smoluchowski Inst Phys, Dept Med Phys, Krakow, Poland.
   [Drozdz, Anna] Jagiellonian Univ, Malopolska Ctr Biotechnol, Krakow, Poland.
   [Ludwig-Slomczynska, Agnieszka H.] Jagiellonian Univ, Ctr Med Genom OMICRON, Med Coll, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Jagiellonian University; Jagiellonian
   University; Collegium Medicum Jagiellonian University
RP Malecki, MT (通讯作者)，Jagiellonian Univ, Dept Metab Dis, Med Coll, Krakow, Poland.; Malecki, MT (通讯作者)，Univ Hosp, Clin Metab Dis, Krakow, Poland.
EM malecki_malecki@yahoo.com
RI Stepien, Ewa/H-7471-2019; Drozdz, Anna/ISB-5280-2023; Hohendorff,
   Jerzy/U-1857-2018
OI Stepien, Ewa/0000-0003-3589-1715; Drozdz, Anna/0000-0003-3999-6725;
   Hohendorff, Jerzy/0000-0003-1153-8669; Ludwig-Słomczyńska, Agnieszka
   H/0000-0002-0548-4767
FU National Science Centre in Poland [2013/11/B/NZ5/03298]
FX The study was funded by the National Science Centre in Poland through
   the Opus Grant "Assessment of Molecular Mechanisms of Negative Pressure
   Wound Therapy in the Treatment of Neuropathic Ulceration in Diabetic
   Foot Syndrome" to MTM (Nr 2013/11/B/NZ5/03298). The authors thank Mrs.
   Katherine Zerebiec for her linguistic review of the manuscript.
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NR 44
TC 8
Z9 10
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD OCT 28
PY 2019
VL 2019
AR 1756798
DI 10.1155/2019/1756798
PG 7
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA JN6CP
UT WOS:000496984300002
PM 31781660
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, YL
   Shi, Y
   Zhu, JY
   Chen, XD
   Yang, RH
   Shu, B
   Zhou, ZH
   Liu, J
   Wu, RQ
   Xie, JL
AF Liu, Yiling
   Shi, Yan
   Zhu, Junyou
   Chen, XiaoDong
   Yang, RongHua
   Shu, Bin
   Zhou, Ziheng
   Liu, Jian
   Wu, Ri-qiang
   Xie, Julin
TI Study on the Effect of the Five-in-One Comprehensive Limb Salvage
   Technologies of Treating Severe Diabetic Foot
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE diabetic foot ulcer; NPWT; revascularization; wound healing; amputation
ID VASCULAR-SURGERY; MANAGEMENT; ULCERS; REVASCULARIZATION; ASSOCIATION;
   GUIDELINES; DIAGNOSIS; ISCHEMIA; THERAPY; SOCIETY
AB Objective: To explore the clinical efficacy and advantages of five-in-one comprehensive limb salvage technologies for the treatment of severe diabetic foot ulcer (DFU). Approach: Clinical data for 120 patients with severe DFU treated between January 2012 and December 2017 were analyzed retrospectively. The control group (48 cases) was treated with traditional therapies, including controlling blood sugar, improving microcirculation, preserving nerve function, and dressing changes, whereas the experimental group (72 cases) was treated with traditional therapy combined with additional techniques, such as early and thorough debridement, negative pressure wound therapy, revascularization, and skin graft or flap. Ankle-brachial index (ABI), transcutaneous oxygen pressure (TcPO2), wound healing rate, healing time, ulcer recurrence rate, and amputation rate were recorded. Results: Compared with the control group, the experimental group significantly improved wound healing rate (93.1% vs. 72.9%; p < 0.01), decreased wound healing time (16.2 +/- 5.4 days vs. 32.2 +/- 7.8 days; p < 0.05), reduced major limb amputation rate (1.4% vs. 10.4%, p < 0.05), and ulcer recurrence rate (5.6% vs. 14.6%; p < 0.05). There were no significant differences in amputation rate between experimental and control group (29.2% vs. 33.3%, p = 0.628). After revascularization, the revascularization group showed significantly improved ABI (0.75 +/- 0.21 vs. 0.35 +/- 0.16, p < 0.05) and TcPO2 (36 +/- 6 mmHg vs. 15 +/- 4 mmHg, p < 0.05). Innovation: We propose a five-in-one comprehensive treatment method, which provides a multidisciplinary cooperative model for comprehensive medical and surgical treatments for DFU. Conclusion: The five-in-one comprehensive limb salvage treatment technologies played a vital role in enhancing the healing rate of severe DFU, shortening the healing time, and reducing the rate of recurrence and major amputation, thus improving the overall quality of life.
C1 [Liu, Yiling; Zhu, Junyou; Shu, Bin; Zhou, Ziheng; Liu, Jian; Xie, Julin] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burn Surg, Guangzhou 510080, Guangdong, Peoples R China.
   [Shi, Yan] Jiangxi Maternal & Child Hlth Hosp, Med Cosmetol Dept, Nanchang, Jiangxi, Peoples R China.
   [Chen, XiaoDong; Yang, RongHua] First Peoples Hosp Foshan, Dept Burn Surg, Foshan, Peoples R China.
   [Wu, Ri-qiang] Yunfu City Peoples Hosp, Dept Burn Surg, Yunfu, Peoples R China.
C3 Sun Yat Sen University
RP Xie, JL (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burn Surg, Guangzhou 510080, Guangdong, Peoples R China.
EM sysxiej190@sohu.com
RI Liu, Yiling/LBH-4975-2024; 谢举临, Julin Xie/LXA-4344-2024; yan,
   shi/HNI-1042-2023
OI yan, shi/0000-0002-3838-2337
FU National Natural Science Foundation of China [81871566, 81671935];
   Science and Technology Planning Project of Guangdong Province, China
   [2017A040405026]; Science and Technology Planning Project of Guangzhou
   City [2018-0402-SF-0686]; Natural Science Foundation of Guangdong
   Province, China [2017A030313619]
FX None declared. This study was supported by the National Natural Science
   Foundation of China (Grant No. 81871566, 81671935), the Science and
   Technology Planning Project of Guangdong Province, China (Grant No.
   2017A040405026), and the Science and Technology Planning Project of
   Guangzhou City (Grant No. 2018-0402-SF-0686), and the Natural Science
   Foundation of Guangdong Province, China (Grant No. 2017A030313619).
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   Yekta Z, 2011, DIABET METAB SYND OB, V4, P371, DOI 10.2147/DMSO.S25309
NR 27
TC 6
Z9 9
U1 0
U2 26
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD DEC 1
PY 2020
VL 9
IS 12
BP 676
EP 685
DI 10.1089/wound.2018.0903
EA NOV 2019
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA OH8LY
UT WOS:000497398400001
PM 33124965
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Yan, YF
   Li, WF
   Song, Y
   Yin, P
   He, ZZ
   Gong, YP
   Peng, LL
AF Yan, Yafeng
   Li, Wenfeng
   Song, Yan
   Yin, Pei
   He, Zongze
   Gong, Yanping
   Peng, Lili
TI Semiclosure wound therapy plus negative pressure wound therapy for an
   older patient with grade 4 diabetic foot with concomitant vascular
   occlusion A case report
SO MEDICINE
LA English
DT Article
DE grade 4 diabetic foot; infection; negative pressure wound therapy; older
   patient; semiclosure of the wound
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; MULTICENTER; PREVENTION; ULCERS
AB Rationale: Grade 4 diabetic foot (DF) is a severe infection that causes bone destruction, osteomyelitis, and osteoarticular damage, which, in turn, can lead to serious dry or wet gangrene, or amputation. DF is extremely difficult to treat.
   Patient concerns: A 71-year-old female patient with long-term diabetes complicated with uremia, who undergoes regular hemodialysis 2 to 3 times per week, was admitted with grade 4 DF with Pseudomonas aeruginosa infection, and concomitant vascular occlusion of the lower extremities. The patient had a concurrent nutrition and electrolyte disorder.
   Diagnoses: The patient was diagnosed with type 2 diabetes, grade 4 DF, postamputation of the 2nd toe, vascular occlusion of the lower extremities, atherosclerosis, uremia, hypoproteinemia, and electrolyte disturbances.
   Interventions: Treatment with antibiotics and comprehensive measures aimed at improving nutrition and microcirculation, controlling blood glucose, as well as balancing electrolytes were performed to ameliorate the general conditions. Nibbled debridement was used to remove devitalized tissues each time to maintain as much vital cells as possible. Open therapy was used for necrotic tissues, and dressings therapy was used simultaneously for the infected lesion. This combined treatment, involving open therapy with dressing, is referred to as "semiclosure wound therapy." Negative pressure wound therapy (NPWT) was used after a fistula formed.
   Outcomes: During the treatment procedure, the gangrene 3rd toe was spontaneously shed; the necrotic 1st toe was removed by surgery. The wound gradually healed after 3 months of open therapy combined with dressing. High location amputation was avoided.
   Lessons: Semiclosure, which constitutes open therapy combined with the use of dressings, plus NPWT can preserve vital skin cells in the wound and control the aggravation of the infection. It is an effective and novel measure that prevents DF amputation in old patient and promotes wound union.
C1 [Yan, Yafeng; Gong, Yanping; Peng, Lili] Chinese People Liberat Army Gen Hosp, Med Ctr 2, Dept Geriatr Endocrinol, Beijing, Peoples R China.
   [Yan, Yafeng; Gong, Yanping] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China.
   [Li, Wenfeng] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Orthoped, Beijing, Peoples R China.
   [Song, Yan; Yin, Pei; He, Zongze] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Nephrol, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese People's Liberation Army
   General Hospital
RP Gong, YP (通讯作者)，Chinese People Liberat Army Gen Hosp, Natl Clin Res, Ctr Geriatr Dis, Med Ctr 2, Beijing, Peoples R China.
EM gypmrp@163.com
FU Military Logistics Research Projects of China [CWS13J054]; Translational
   Medicine Projects of the Chinese People's Liberation Army General
   Hospital [2017TM-021]; Clinical Scientific Research Support Funds of the
   Chinese People's Liberation Army General Hospital [2018 FC - WJFWZX
   -1-13]
FX This study was supported by the Military Logistics Research Projects of
   China (No. CWS13J054), the Translational Medicine Projects of the
   Chinese People's Liberation Army General Hospital (No. 2017TM-021), and
   the Clinical Scientific Research Support Funds of the Chinese People's
   Liberation Army General Hospital (2018 FC - WJFWZX -1-13).
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NR 15
TC 2
Z9 4
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2019
VL 98
IS 44
AR e17786
DI 10.1097/MD.0000000000017786
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JO7BV
UT WOS:000497731800111
PM 31689851
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ivanzov, S
   Soynov, I
   Kulyabin, Y
   Zubritskiy, A
   Voitov, A
   Omelchenko, A
   Arkhipov, A
   Bogachev-Prokophiev, A
AF Ivanzov, Sergey
   Soynov, Ilya
   Kulyabin, Yuriy
   Zubritskiy, Alexey
   Voitov, Alexey
   Omelchenko, Alexander
   Arkhipov, Alexey
   Bogachev-Prokophiev, Alexander
TI Vacuum-assisted closure versus closed irrigation for deep sternal wound
   infection treatment in infants: a propensity score-matched study
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Vacuum-assisted closure therapy; Closed irrigation drainage technique;
   Sepsis; Recurrence of mediastinitis
ID PEDIATRIC CARDIAC-SURGERY; RISK ADJUSTMENT; MEDIASTINITIS; CHILDREN;
   PREVENTION; MANAGEMENT; STERNOTOMY; RUPTURE
AB OBJECTIVES: This study aimed to compare vacuum-assisted closure therapy (VAC) and closed irrigation drainage therapy (CID) for deep sternal wound infection treatment in infants.
   METHODS: From January 2008 to March 2018, 69 patients (1.73%) had deep sternal wound infection. They were divided into 2 groups: patients treated with VAC therapy (VAC group, 29 patients) and those treated with CID therapy (CID group, 40 patients). After performing a propensity score analysis (1:1) for the entire sample, 16 patients receiving VAC therapy were matched with 16 patients receiving CID therapy.
   RESULTS: No significant difference was noted between both groups regarding age [d=0.045; 95% confidence interval (CI) 0.99-1.07], gender (d=0.001; 95% CI 0.22-4.45), weight (d=0.011; 95% CI 0.73-1.35), body surface area (d=-0.023; 95% CI 0.01-5733.08), cardiopulmonary bypass (d=0; 95% CI 0.16-5.90) and open chest duration (d=-0.112; 95% CI 0.31-5.16). Five patients died in the CID group (31.25%) during hospital stay, and there were no deaths in the VAC group (P=0.024). Recurrence of mediastinitis occurred in 1 patient (6.25%) from the VAC group and in 6 patients (37.5%) from the CID group (P=0.037). The multivariable regression analysis revealed that the CID method was the only risk factor for remediastinitis (odds ratio 17.3; 95% CI 1.04-286.75; P=0.046).
   CONCLUSIONS: Use of VAC therapy in infants with deep sternal wound infection was associated with a substantial decrease in the mortality rate and duration of therapy compared with CID technique. The CID technique was an independent risk factor for recurrence of mediastinitis.
C1 [Ivanzov, Sergey; Soynov, Ilya; Kulyabin, Yuriy; Zubritskiy, Alexey; Voitov, Alexey; Omelchenko, Alexander; Arkhipov, Alexey; Bogachev-Prokophiev, Alexander] Natl Med Res Ctr, Dept Congenital Heart Dis, Rechkunovskaya St 15, Novosibirsk 630055, Russia.
C3 Meshalkin National Medical Research Center
RP Soynov, I (通讯作者)，Natl Med Res Ctr, Dept Congenital Heart Dis, Rechkunovskaya St 15, Novosibirsk 630055, Russia.
EM I_soynov@mail.ru
RI Kulyabin, Yuriy/O-8941-2017; Voitov, Alexey/AAC-9988-2022; Soynov,
   Ilya/AAD-9872-2020
OI Kulyabin, Yuriy/0000-0002-2361-5847; Arkhipov,
   Alexey/0000-0003-3234-5436; Zubritskiy, Alexey/0000-0003-4666-2571;
   Voitov, Alexey/0000-0003-3797-4899; Soynov, Ilya/0000-0003-3691-2848
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NR 27
TC 6
Z9 9
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD NOV
PY 2019
VL 29
IS 5
BP 776
EP 782
DI 10.1093/icvts/ivz167
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA JP3KX
UT WOS:000498167500018
PM 31361302
OA Bronze
DA 2026-07-24
ER
PT J
AU Tyagi, V
   Kahan, J
   Huang, P
   Leslie, MP
   Rubin, LE
   Gibson, DH
AF Tyagi, Vineet
   Kahan, Joseph
   Huang, Patrick
   Leslie, Michael P.
   Rubin, Lee E.
   Gibson, David H.
TI Negative Pressure Incisional Therapy and Infection After Direct Anterior
   Approach Primary Total Hip Arthroplasy
SO ORTHOPEDICS
LA English
DT Article
ID PERIPROSTHETIC JOINT INFECTION; WOUND THERAPY; RISK-FACTORS; KNEE
   ARTHROPLASTY; UNITED-STATES; REVISION HIP; EPIDEMIOLOGY; PREVALENCE;
   DRESSINGS; OBESITY
AB With the aging of the US population, total hip arthroplasty (THA) is becoming an increasingly common procedure. A major concern after THA is reducing infection rates, as infections can cause devastating complications. Improve A sterile technique, standardized infection control protocols, and novel dressing have been used to reduce postoperative surgical site infections (SSIs), the of either silver-impregnated dry dressings or easily applied incisional negative pressure dressings is aimed at reducing the rates of SSIs after primary anterior THA. The authors retrospectively reviewed the medical records of 275 patients who underwent anterior THA at their institution during a 1-year period. Patients were separated into groups based on their surgical dressing. Rates of SSI were documented, and the effects of various factors, including age, sex, body mass index, and comorbidities, were compared between the 2 cohorts. the authors also analyzed high-risk patients to determine whether easily applied incisional negative pressure dressings reduced infections. Me use of easily applied incisional negative pressure dressings after primary anterior THA did not have a statistically significant impact on SSI rate (P =.42). There was also no difference in SSI, readmission, or reoperation in the high-risk group. The goal of using an incisional negative pressure wound therapy device is to help further decrease the risk of SSI. This study's findings suggest that the SSI rate in this group did not differ from that in the standard dressing group, such that the prophylactic use of a negative pressure wound therapy device is riot indicated for either standard or high-risk patients undergoing primary anterior approach THA.
C1 [Tyagi, Vineet; Kahan, Joseph; Huang, Patrick; Leslie, Michael P.; Rubin, Lee E.; Gibson, David H.] Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 47 Coll St, New Haven, CT 06520 USA.
C3 Yale University
RP Tyagi, V (通讯作者)，Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 47 Coll St, New Haven, CT 06520 USA.
EM vineet.tyagi@yale.edu
RI Kahan, Joseph/AAH-2682-2019
CR Baek SH, 2014, WORLD J ORTHOP, V5, P362, DOI 10.5312/wjo.v5.i3.362
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NR 25
TC 12
Z9 12
U1 0
U2 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD NOV-DEC
PY 2019
VL 42
IS 6
BP E539
EP E544
DI 10.3928/01477447-20190906-06
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA JP8LU
UT WOS:000498511000009
PM 31505014
DA 2026-07-24
ER
PT J
AU Gao, X
   Yin, HL
   Sun, JX
AF Gao, Xu
   Yin, Hailei
   Sun, Jixia
TI Preoperative irrigation and vacuum sealing drainage with
   antibiotic-containing drainage fluid of foot and ankle wounds improves
   outcome of reconstructive skin flap surgery
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Flap reconstruction; Bacterial infection; Inflammatory response
ID ASSISTED CLOSURE; THERAPY; BACTERIAL; INFECTIONS; PREVENTION; MANAGEMENT
AB Objectives By observing the infection and soft tissue defect on the wound surface of the foot and ankle, this paper attempts to explore the effect of preoperative irrigation and vacuum sealing drainage with antibiotic-containing drainage fluid (abPI-VSD) on the bacterial quantity and the local inflammatory response at the flap, and further to provide a basis for applying this technique before a reconstructive skin flap surgery of foot and ankle wounds. Methods Seventy-five patients were randomly divided into two groups, and all surgeries were done by one physician. The flap reconstructions were done to 31 cases with the abPI-VSD being used (group A); the flap reconstructions were done to the rest 44 cases after wound cleaning using antibiotic irrigation solution without the use of the abPI-VSD (group B). Quantitative bacteriology was made to group A before and after the use of abPI-VSD; quantitative bacteriology was made to group B before and after wound cleaning. Then, the reconstructive skin flap surgery was done. After the surgeries, the time of local inflammatory response at the flap in both groups were recorded. The measured bacterial quantity was evaluated in logarithm and by t test. Results The bacterial quantity was 3.2 +/- 1.9 x 10(7) cfu/g in group A before the use of abPI-VSD and 2.3 +/- 2.0 x 10(7) in group B (P > 0.05) before debridement. The bacterial quantity was 1.2 +/- 2.0 x 10(4) cfu/g in group A after abPI-VSD and was 2.9 +/- 4.0 x 10(6) in group B after wound cleaning (P < 0.05). The time of postoperative inflammatory response in the flap was 8 +/- 2.5 days in group A and 13 +/- 3.4 days in group B (P < 0.05). Conclusions abPI-VSD can distinctly reduce the bacterial quantity on the surface of the wound, provide a good condition of tissue bed for the flap reconstruction, and effectively control the local inflammatory response at the flap and hence improve the survival quality of the flap.
C1 [Gao, Xu] Qingdao Univ, Dept Orthoped, Qingdao 266071, Shandong, Peoples R China.
   [Yin, Hailei] 971 Hosp People Liberat Army, Dept Orthoped, 22 Min Jiang Rd, Qingdao 266071, Shandong, Peoples R China.
   [Sun, Jixia] Qingdao Cent Hosp, Dept Foot & Hand Trauma Surg, Qingdao 266071, Shandong, Peoples R China.
C3 Qingdao University
RP Yin, HL (通讯作者)，971 Hosp People Liberat Army, Dept Orthoped, 22 Min Jiang Rd, Qingdao 266071, Shandong, Peoples R China.
EM gukedor@163.com
RI yin, hailei/LGZ-3641-2024
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NR 35
TC 8
Z9 12
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD NOV 20
PY 2019
VL 14
IS 1
AR 374
DI 10.1186/s13018-019-1418-0
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA JQ0OZ
UT WOS:000498655800001
PM 31747959
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fang, CL
   Changchien, CH
   Chen, MS
   Hsu, CH
   Tsai, CB
AF Fang, Chien-Liang
   Changchien, Chih-Hsuan
   Chen, Ming-Shan
   Hsu, Chin-Hao
   Tsai, Chong-Bin
TI Closed incision negative pressure therapy following abdominoplasty after
   breast reconstruction with deep inferior epigastric perforator flaps
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE breast reconstruction; cicatrix; negative pressure wound therapy;
   surgical wound; wound healing
ID DIEP
AB Autologous breast reconstructions using deep inferior epigastric perforator (DIEP) flaps create a large incision, presenting an opportunity for surgical site complications. In this pilot study, we aimed to examine outcomes in DIEP donor site incisions managed with standard dressings (control; n = 5) or closed incision negative pressure therapy (ciNPT; n = 5). We observed no significant differences between group age, body mass index, and past medical history. Both treatment groups had a similar duration of hospital stay, the number of blood transfusions, and pain scores on postoperative day 2 (P > .05). There was a trend of higher drainage (P = .251) and shorter time to incision healing (P = .067) in the ciNPT group than the control though the difference was not statistically significant. We did observe a significant improvement in scar pigmentation, vascularity, and pliability at 3, 6, and 12 months post-surgery in the ciNPT group compared with control (P < .05). No surgical site complications were reported in the ciNPT group within the follow-up period. In the control group, one patient developed wound edge fat necrosis requiring reoperation. In conclusion, we report that ciNPT is a useful incision management system for DIEP flap donor site incisions and it facilitated improved scar quality over standard dressings in this small pilot study. Further clinical studies are required to assess the full advantages provided by ciNPT.
C1 [Fang, Chien-Liang; Changchien, Chih-Hsuan; Hsu, Chin-Hao] Ditmanson Med Fdn, Dept Surg, Div Plast & Reconstruct Surg, Chia Yi Christian Hosp, 539 Jhongsiao Rd, Chiayi 60002, Taiwan.
   [Fang, Chien-Liang] Asia Univ, Coll Med & Hlth Sci, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan.
   [Changchien, Chih-Hsuan; Chen, Ming-Shan] Asia Univ, Coll Med & Hlth Sci, Dept Biotechnol, Taichung, Taiwan.
   [Chen, Ming-Shan] Ditmanson Med Fdn, Dept Anesthesiol, Chia Yi Christian Hosp, Chiayi, Taiwan.
   [Tsai, Chong-Bin] Ditmanson Med Fdn, Dept Ophthalmol, Chia Yi Christian Hosp, Chiayi, Taiwan.
   [Tsai, Chong-Bin] Asia Univ, Coll Med & Hlth Sci, Dept Optometry, Taichung, Taiwan.
C3 Asia University Taiwan; Asia University Taiwan; Asia University Taiwan
RP Fang, CL (通讯作者)，Ditmanson Med Fdn, Dept Surg, Div Plast & Reconstruct Surg, Chia Yi Christian Hosp, 539 Jhongsiao Rd, Chiayi 60002, Taiwan.
EM fangcl68@hotmail.com
RI Fang, Chien-Liang/ABF-4536-2020
OI Fang, Chien-Liang/0000-0001-6437-8721
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
   Abesamis GM, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002141
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   Tanaydin V, 2018, AESTHET PLAST SURG, V42, P927, DOI 10.1007/s00266-018-1095-0
NR 20
TC 25
Z9 29
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2020
VL 17
IS 2
BP 326
EP 331
DI 10.1111/iwj.13273
EA NOV 2019
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KR3MH
UT WOS:000498840200001
PM 31777164
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hardy, EJO
   Herrod, PJ
   Doleman, B
   Phillips, HG
   Ranat, R
   Lund, JN
AF Hardy, Edward John Oliver
   Herrod, Philip J.
   Doleman, Brett
   Phillips, Hannah G.
   Ranat, Reesha
   Lund, Jonathan N.
TI Surgical interventions for the treatment of sacrococcygeal pilonidal
   sinus disease in children: A systematic review and meta-analysis
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE Pilonidal sinus; Adolescent; Child; Systematic Review; Surgery
ID VACUUM-ASSISTED CLOSURE; CLEFT LIFT PROCEDURE; LIMBERG FLAP; RHOMBOID
   EXCISION; WOUND MANAGEMENT; EARLY EXPERIENCE; OUTCOMES; SURGERY
AB Background: Pilonidal sinus disease (PNS) is not uncommon in children. Controversy remains over the best treatment and there is limited evidence. This systematic review and meta-analysis aims to establish which techniques have the best outcomes in children.
   Methods: MEDLINE, EMBASE and CENTRAL databases were searched. Studies reporting treatment outcomes for PNS in children were included.
   Results: Open healing has pooled risk of recurrence of 26% (95%Cl 15-38%), risk of wound complication of 21% (9-36%) and wound healing ranged from 38-92 days. Midline primary closure has pooled risk of recurrence of 12% (8-18%), risk of wound complication of 30% (19-46%) and wound healing ranged from 8 to 32 days. Off-midline primary closure has pooled risk of recurrence of 6% (1-15%), risk of wound complication of 14% (6-25%) and wound healing was 27 days. VAC therapy has pooled risk of recurrence of 20% (0-65%) and wound healing ranged from 38 to 92 days. Minimally invasive techniques has pooled risk of recurrence of 7% (1-16%) and wound healing ranged from 21-30 days. Marsupialisation has pooled risk of recurrence of 6% (0-22%), and wound healing ranged from 6 to 41 days.
   Conclusion: Evidence for management of PNS in children is poor. Off-midline primary closure, minimally invasive techniques, and marsupialisation have the best outcomes. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Hardy, Edward John Oliver; Herrod, Philip J.; Lund, Jonathan N.] Royal Derby Hosp, Dept Gen Surg, Derby DE22 3NE, NE, England.
   [Hardy, Edward John Oliver; Herrod, Philip J.; Doleman, Brett; Phillips, Hannah G.; Ranat, Reesha; Lund, Jonathan N.] Univ Nottingham, Dept Surg, Div Med Sci & Grad Entry Med, Derby DE22 2DT, England.
C3 University of Nottingham; University of Nottingham
RP Hardy, EJO (通讯作者)，Royal Derby Hosp, Dept Surg, Derby DE22 3NE, England.
EM edward.hardy@nhs.net
RI ; Lund, Jonathan/K-6631-2019
OI Doleman, Brett/0000-0003-4707-4755; Herrod, Philip/0000-0002-6839-3897;
   Lund, Jonathan/0000-0001-5195-2181
CR Abu Galala KH, 1999, EUR J SURG, V165, P468
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NR 39
TC 35
Z9 41
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD NOV
PY 2019
VL 54
IS 11
BP 2222
EP 2233
DI 10.1016/j.jpedsurg.2019.02.058
PG 12
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA JQ3LQ
UT WOS:000498851100004
PM 30940347
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Wang, C
   Zhang, JX
   Liu, ZZ
AF Wang, Chao
   Zhang, Jixun
   Liu, Zhenzhong
TI Vacuum-assisted closure therapy combined with bi-pectoral muscle flap
   for the treatment of deep sternal wound infections
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bi-pectoral muscle flap; deep sternal wound infections; vacuum-assisted
   closure therapy
ID SURGICAL SITE INFECTION; POSTSTERNOTOMY MEDIASTINITIS; CLOSED DRAINAGE;
   SURGERY; MANAGEMENT
AB Deep sternal wound infection (DSWI) is a fatal complication after median sternotomy. This study was to assess the effect of vacuum-assisted closure (VAC) combined with bi-pectoral muscle advancement flap therapy on rehabilitation for the treatment of DSWI. Fifty-two patients with DSWI underwent treatment of VAC and bi-pectoral muscle flap. These patients were followed-up 12 months postoperation. The patient characteristics, duration of VAC therapy, the mean hospital stay, and postoperative complications were retrospectively analysed. All patients underwent 1 to 3 VAC treatment sessions before closure. Fifty-one of 52 DSWI patients were cured to discharge; the mean hospital stay was 26.5 days. The drainage tube continued to drain a large amount of bloody fluid in three patients after the wound was closed. Respiratory failure occurred in one patient with severe mediastinal and pulmonary infections and died eventually in hospital. One patient died of acute cerebral haemorrhage during the12-month follow-up. VAC therapy combined with bi-pectoral muscle flap is a simple and effective treatment for DSWIs with short hospital stays and few complications. However, this is a retrospective case series presentation with no comparison group; further large-scale controlled studies are needed.
C1 [Wang, Chao; Zhang, Jixun; Liu, Zhenzhong] Shandong Univ, Hosp 2, Dept Burn & Plast Surg, Jinan 250033, Shandong, Peoples R China.
C3 Shandong University
RP Liu, ZZ (通讯作者)，Shandong Univ, Hosp 2, Dept Burn & Plast Surg, Jinan 250033, Shandong, Peoples R China.
EM drliuzhenzhong@163.com
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   Singh Kimberly, 2011, Semin Plast Surg, V25, P25, DOI 10.1055/s-0031-1275168
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NR 21
TC 9
Z9 13
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2020
VL 17
IS 2
BP 332
EP 338
DI 10.1111/iwj.13277
EA DEC 2019
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KR3MH
UT WOS:000499634900001
PM 31788960
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Girard, P
   Plancq, MC
   Tourneux, P
   Deroussen, F
   Gouron, R
   Klein, C
AF Girard, P.
   Plancq, M. -C.
   Tourneux, P.
   Deroussen, F.
   Gouron, R.
   Klein, C.
TI Extravasation of calcium solution in the child: Value of
   negative-pressure wound therapy
SO ARCHIVES DE PEDIATRIE
LA English
DT Article
DE Extravasation; Calcium solutions; Negative-pressure wound therapy
ID MANAGEMENT; GLUCONATE; EFFICACY
AB The extravasation of a calcium solution into soft tissue constitutes a medical emergency, and a lack of adequate management can lead to significant functional and cosmetic sequelae. Here, we report on the management of and long-term outcome in two children who experienced calcium infusion leakage. We also describe the emergency procedures used in cases of extravasation and discuss the role of negative pressure wound therapy as an appropriate adjunct to conventional techniques for dealing with serious extravasation-related injuries. (C) 2019 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.
C1 [Girard, P.; Plancq, M. -C.; Deroussen, F.; Gouron, R.; Klein, C.] CHU Amiens Picardie, Grp Hosp Sud, Serv Orthoped Pediat, F-80054 Amiens 1, France.
   [Tourneux, P.] Grp Hosp Sud, Pole Femme Couple Enfant Med Neonatale & Reanimat, F-80054 Amiens 1, France.
C3 Universite de Picardie Jules Verne (UPJV); CHU Amiens
RP Klein, C (通讯作者)，CHU Amiens Picardie, Grp Hosp Sud, Serv Orthoped Pediat, F-80054 Amiens 1, France.
EM celinekleinfr@yahoo.fr
RI Gouron, Richard/AGM-3039-2022; Tourneux, Pierre/AAX-3748-2021
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NR 13
TC 6
Z9 8
U1 0
U2 6
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0929-693X
EI 1769-664X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD OCT
PY 2019
VL 26
IS 7
BP 407
EP 410
DI 10.1016/j.arcped.2019.09.011
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA JR6WV
UT WOS:000499764100003
PM 31630900
OA Bronze
DA 2026-07-24
ER
PT J
AU de Souza, GMC
   Amorim, CCB
   Vallejo, CEA
   Sternick, MB
   da Costa, SM
   Sobral, CS
   Ferreirav, LM
AF Costa de Souza, Gustavo Moreira
   Bizzotto Amorim, Camila Camargos
   Astudillo Vallejo, Cristian Esteban
   Sternick, Marcelo Back
   da Costa, Sergio Moreira
   Sobral, Christiane Steponavicius
   Ferreirav, Lydia Masako
TI Fat grafting associated with negative pressure wound therapy
SO ACTA CIRURGICA BRASILEIRA
LA English
DT Article
DE Negative-Pressure Wound Therapy; Wound Healing; Transplantation;
   Autologous; Biocompatible Materials
AB Purpose: To describe a case report of FG associated with NPWT in the treatment of complex wound on the distal third of the lower limb with bone exposure.
   Case Report: A 59-year-old patient with chronic left tibial osteomyelitis since childhood underwent extensive debridement of the distal tibial diaphysis (40% of bone thickness per 10 cm extension) and placement of bioactive glass S53P4. Distal necrosis occurred in the fasciocutaneous flap used as the primary bone coverage. After flap debridement, the case was resolved with FG, directly on the exposed bone and biomaterial, associated with NPWT. Three weeks after the first FG session over bony tissue, 100% granulation was achieved with NPWT. The closure was completed with thin laminated skin graft over the granulated wound area.
   Discussion: The association of FG and NPWT is not known in the clinical practice. Except for the only one experimental study described by Kao et a', the theme was not addressed in the medical literature before. In this clinical case, the result obtained regarding the granulation tissue formation drew attention and prevented the use of more complex flaps such as the microsurgical ones. Accelerated granulation tissue formation was observed, filling an extensive and deep bone defect, even with infected bone and biomaterial. Low morbidity and no complications were observed with the use of FG associated with NPWT. When the grafted fat was compacted with the NPWT, it seemed to behave as a true autologous biological matrix with large amount of cells. To date, scientific studies on fat grafting have focused on the cellular aspect (adipocytes and mesenchymal cells), growth factors and fat differentiation in different tissues. The property of aspirated adipose tissue as a biological matrix seemed to be revealed by the application of NPWT in association with FG. This new roll for the aspirated fat tissue may represent a new research field in plastic surgery.
C1 [Costa de Souza, Gustavo Moreira] Univ Fed Sao Paulo UNIFESP, Postgrad Program Translat Surg, Div Plast Surg, Dept Surg, Sao Paulo, SP, Brazil.
   [Bizzotto Amorim, Camila Camargos; Astudillo Vallejo, Cristian Esteban] Hosp Felicio Rocho, Plast Surg & Burn Clin, Postgrad Program Plast Surg, Surg, Belo Horizonte, MG, Brazil.
   [Sternick, Marcelo Back] Hosp Felicio Rocho, Orthopaed Surg Div, Belo Horizonte, MG, Brazil.
   [da Costa, Sergio Moreira] Hosp Felicio Rocho, Div Plast Surg, Belo Horizonte, MG, Brazil.
   [Sobral, Christiane Steponavicius] Hosp Defeitos Face Cruz Vermelha Brasileira, Div Plast Surg, Sao Paulo, SP, Brazil.
   [Ferreirav, Lydia Masako] Univ Fed Sao Paulo, Div Plast Surg, Sao Paulo, SP, Brazil.
   [Ferreirav, Lydia Masako] CNPq, Sao Paulo, SP, Brazil.
   [Ferreirav, Lydia Masako] CAPES, Med 3, Sao Paulo, SP, Brazil.
   [Costa de Souza, Gustavo Moreira; Bizzotto Amorim, Camila Camargos; Astudillo Vallejo, Cristian Esteban; Sternick, Marcelo Back; da Costa, Sergio Moreira; Sobral, Christiane Steponavicius; Ferreirav, Lydia Masako] Hosp Felicio Rocho, Plast Surg & Burn Clin, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES)
RP de Souza, GMC (通讯作者)，Rua Timbiras 3642,Sala 504, BR-30140062 Belo Horizonte, MG, Brazil.
EM gustavomcsouza@gmail.com
RI ; Sternick, Marcelo/G-2024-2014
OI Steponavicius Sobral, Christiane/0000-0003-3924-147X; Amorim,
   Camila/0000-0002-9090-5158; Souza, Gustavo/0000-0003-0868-6505;
   Sternick, Marcelo/0000-0002-3631-7734
CR Hultman CS, 2014, ANN PLAS SURG, V72, pS202, DOI 10.1097/SAP.0000000000000089
   Kao HK, 2015, BRIT J SURG, V102, P998, DOI 10.1002/bjs.9826
   LIMA RENAN VICTOR KÜMPEL SCHMIDT, 2017, Rev. Col. Bras. Cir., V44, P81, DOI [10.1590/0100-69912017001001, 10.1590/0100-69912017001001]
   Ojansivu M, 2018, EUR CELLS MATER, V35, P54, DOI 10.22203/eCM.v035a05
NR 4
TC 0
Z9 1
U1 1
U2 3
PU ACTA CIRURGICA BRASILEIRA
PI SAO PAULO
PA ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL
SN 0102-8650
EI 1678-2674
J9 ACTA CIR BRAS
JI Acta Cir. Bras.
PY 2019
VL 34
IS 9
AR UNSP e201900907
DI 10.1590/s0102-865020190090000007
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JR7HL
UT WOS:000499791700006
PM 31800680
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ludwig-Slomczynska, AH
   Borys, S
   Seweryn, MT
   Hohendorff, J
   Kapusta, P
   Kiec-Wilk, B
   Pitera, E
   Wolkow, PP
   Malecki, MT
AF Ludwig-Slomczynska, A. H.
   Borys, S.
   Seweryn, M. T.
   Hohendorff, J.
   Kapusta, P.
   Kiec-Wilk, B.
   Pitera, E.
   Wolkow, P. P.
   Malecki, M. T.
TI DNA methylation analysis of negative pressure therapy effect in diabetic
   foot ulcers
SO ENDOCRINE CONNECTIONS
LA English
DT Article
DE diabetic foot syndrome; diabetic foot ulceration; DNA methylation;
   negative-pressure wound therapy; type 2 diabetes
ID VACUUM-ASSISTED CLOSURE; ALTERNATIVE ACTIVATION; CHRONIC INFLAMMATION;
   CLASSICAL PATHWAY; GENE-EXPRESSION; ELEVATED LEVELS; COMPLEMENT; GROWTH;
   INTERVENTIONS; EPIDEMIOLOGY
AB Objective: Negative pressure wound therapy (NPWT) has been used to treat diabetic foot ulcerations (DFUs). Its action on the molecular level, however, is only partially understood. Some earlier data suggested NPWT may be mediated through modification of local gene expression. As methylation is a key epigenetic regulatory mechanism of gene expression, we assessed the effect of NPWT on its profile in patients with type 2 diabetes (T2DM) and neuropathic non-infected DFUs.
   Methods: Of 36 included patients, 23 were assigned to NPWT and 13 to standard therapy. Due to ethical concerns, the assignment was non-randomized and based on wound characteristics. Tissue samples were obtained before and 8 +/- 1 days after therapy initiation. DNA methylation patterns were checked by Illumina Methylation EPIC kit.
   Results: In terms of clinical characteristics, the groups presented typical features of T2DM; however, the NPWT group had significantly greater wound area: 16.8 cm2 vs 1.4 cm(2) (P = 0.0003). Initially only one region at chromosome 5 was differentially methylated. After treatment, 57 differentially methylated genes were found, mainly located on chromosomes 6 (chr6p21) and 20 (chr20p13); they were associated with DNA repair and autocrine signaling via retinoic acid receptor. We performed differential analyses pre treatment and post treatment. The analysis revealed 426 differentially methylated regions in the NPWT group, but none in the control group. The enrichment analysis showed 11 processes significantly associated with NPWT, of which 4 were linked with complement system activation. All but one were hypermethylated after NPWT.
   Conclusion: The NPWT effect on DFUs may be mediated through epigenetic changes resulting in the inhibition of complement system activation.
C1 [Ludwig-Slomczynska, A. H.; Seweryn, M. T.; Kapusta, P.; Pitera, E.; Wolkow, P. P.] Jagiellonian Univ, Ctr Med Genom OMICRON, Med Coll, Krakow, Poland.
   [Borys, S.; Hohendorff, J.; Kiec-Wilk, B.; Malecki, M. T.] Jagiellonian Univ, Dept Metab Dis, Med Coll, Krakow, Poland.
   [Borys, S.; Hohendorff, J.; Kiec-Wilk, B.; Malecki, M. T.] Univ Hosp, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Wolkow, PP (通讯作者)，Jagiellonian Univ, Ctr Med Genom OMICRON, Med Coll, Krakow, Poland.; Malecki, MT (通讯作者)，Jagiellonian Univ, Dept Metab Dis, Med Coll, Krakow, Poland.; Malecki, MT (通讯作者)，Univ Hosp, Krakow, Poland.
EM pawel.wolkow@uj.edu.pl; maciej.malecki@uj.edu.pl
RI Seweryn, Michal/OEO-9216-2025; Pitera, Ewelina/G-6432-2019; Hohendorff,
   Jerzy/U-1857-2018; Wolkow, Pawel/AAI-4222-2021
OI Seweryn, Michal/0000-0002-9090-3435; Ludwig-Słomczyńska, Agnieszka
   H/0000-0002-0548-4767; Pitera, Ewelina/0000-0001-6208-5976; Hohendorff,
   Jerzy/0000-0003-1153-8669; Kapusta, Przemysław/0000-0003-4467-1175;
   Wolkow, Pawel/0000-0002-9322-5545
FU National Science Centre in Poland [2013/11/B/NZ5/03298]; European Union
   [FP7-REGPOT-2011-1, 286038]
FX The study was funded by the National Science Centre in Poland through
   the Opus Grant 'Assessment of molecular mechanisms of negative pressure
   wound therapy in the treatment of neuropathic ulceration in diabetic
   foot syndrome' to M T M (Nr 2013/11/B/NZ5/03298). The Omicron laboratory
   was funded by the European Union (7th Framework Programme, Call number
   FP7-REGPOT-2011-1, Grant number 286038).
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NR 45
TC 15
Z9 18
U1 0
U2 6
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD NOV
PY 2019
VL 8
IS 11
BP 1474
EP 1482
DI 10.1530/EC-19-0373
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JS3XM
UT WOS:000500241600006
PM 31634866
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Xu, J
   Wang, QY
   Li, W
AF Xu, Jie
   Wang, Qiao-Yun
   Li, Wei
TI Autologous platelet-rich gel and continuous vacuum sealing drainage for
   the treatment of patients with diabetic foot ulcer Study Protocol
SO MEDICINE
LA English
DT Review
DE autologous platelet-rich gel; continuous vacuum sealing drainage;
   diabetic foot ulcer; efficacy; safety
ID PLASMA GEL; MANAGEMENT
AB Background: Research focusing on the efficacy of autologous platelet-rich gel (APRG) and continuous vacuum sealing drainage (CVSD) for diabetic foot ulcer (DFU) is increasing. Despite increasing knowledge on this theme, its results remain inconsistent. Thus, we will provide insight into the efficacy of APRG and CVSD for patients with DFU.
   Methods: We will search electronic databases of MEDILINE, EMBASE, Cochrane Library, CINAHL, AMED, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from inception to October 1, 2019. No language limitation is utilized to these databases. Two authors will independently perform study selection, data extraction, and risk of bias assessment. Disagreements between 2 authors will be solved through discussion with a third author.
   Results: The efficacy and safety of APRG and CVSD for patients with DFU will be assessed by the time to complete healing, proportion of ulcers healed within trial period, change of size of ulcer, health-related quality of life, patient length of hospital stay, and adverse events.
   Conclusion: The results of this study will provide helpful evidence of APRG and CVSD for patients with DFU.
C1 [Xu, Jie; Li, Wei] Yanan Univ Affiliated Hosp, Dept Endocrine & Metab, 43 Beida St, Yanan 716000, Shaanxi, Peoples R China.
   [Wang, Qiao-Yun] Yanan Univ Affiliated Hosp, Dept Ultrasound Diag, Yanan, Peoples R China.
C3 Yanan University; Yanan University
RP Li, W (通讯作者)，Yanan Univ Affiliated Hosp, Dept Endocrine & Metab, 43 Beida St, Yanan 716000, Shaanxi, Peoples R China.
EM weill3328@outlook.com
FU Yan'an Science and Technology Huimin Project [2016-HM-08-01]
FX This study is supported by the Yan'an Science and Technology Huimin
   Project (2016-HM-08-01). The funder did not involve any parts of this
   study.
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NR 26
TC 11
Z9 13
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2019
VL 98
IS 46
AR e17928
DI 10.1097/MD.0000000000017928
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JS3YH
UT WOS:000500243900047
PM 31725645
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yao, Z
   Tian, WL
   Xu, X
   Zhao, RS
   Huang, M
   Zhao, YZ
   Chen, XH
AF Yao, Zheng
   Tian, Weiliang
   Xu, Xin
   Zhao, Risheng
   Huang, Ming
   Zhao, Yunzhao
   Chen, Xinhao
TI The Double-Lumen Irrigation-Suction Tube in The Management of Incisional
   Surgical Site Infection After Enterocutaneous Fistula Excisions: An
   Observational Study
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Article
DE Management; surgical site infection; enterocutaneous fistula;
   double-lumen irrigation-suction tube; excisions; observational study
ID PRESSURE WOUND THERAPY; COST; PREVENTION; DRAINAGE; SURGERY; CLOSURE;
   TROCAR; RATES
AB Background: This study aimed to investigate the effect of double-lumen irrigation-suction tube (DLIST) in the management of surgical site infections (SSIs) after enterocutaneous fistula (ECF) excisions. Method: From January 2016 to December 2017 medical records of patients with ECF excisions were reviewed. Patients with primary superficial SSI were divided into group a (treated with DLIST) and b (treated with delayed primary closures). Patients with primary deep SSI were divided into group A (treated with DLIST) and B (treated with vacuum-assisted closure [VAC]). The effect of the DLIST was evaluated. Results: There were 32 in group a and 27 in group b. The therapeutic time and cost in group a were lower (13.13 +/- 2.37 d vs. 24.89 +/- 7.44 d; p < .001; $1456 +/- 302 vs.$2784 +/- 583; p < .001). There were 21 in group A and 23 in group B. While the therapeutic time of group A was longer, the cost was lower ($1717 +/- 404 vs. $2636 +/- 592; p < .001). Conclusions: Placing DLIST is an effective and cheap method to treat superficial SSI after ECF excisions. The cost of DLIST in treatment of deep SSI is lower, while the effect of VAC is better.
C1 [Yao, Zheng; Xu, Xin; Zhao, Risheng; Huang, Ming; Chen, Xinhao] Jiangning Hosp, Dept Gen Surg, Hushan Rd 169, Nanjing, Jiangsu, Peoples R China.
   [Tian, Weiliang; Zhao, Yunzhao] Jinling Hosp, Dept Gen Surg, Zhongshan Rd 305 East, Nanjing, Jiangsu, Peoples R China.
RP Zhao, RS (通讯作者)，Jiangning Hosp, Dept Gen Surg, Hushan Rd 169, Nanjing, Jiangsu, Peoples R China.; Zhao, YZ (通讯作者)，Jinling Hosp, Dept Gen Surg, Zhongshan Rd 305 East, Nanjing, Jiangsu, Peoples R China.
EM Dr_zhaorisheng@163.com; Dr_zhaoyunzhao@163.com
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NR 27
TC 9
Z9 10
U1 1
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0894-1939
EI 1521-0553
J9 J INVEST SURG
JI J. Invest. Surg.
PD AUG 9
PY 2021
VL 34
IS 7
BP 791
EP 797
DI 10.1080/08941939.2019.1693667
EA DEC 2019
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SS3OL
UT WOS:000500425000001
PM 31795782
DA 2026-07-24
ER
PT J
AU Yang, XF
   Aihemaiti, M
   Zhang, H
   Jiang, L
   Zhang, GX
   Qin, ML
   Pan, YH
   Wen, XM
   Chan, FSY
   Fan, JKM
AF Yang, Xuefei
   Aihemaiti, Maimaiti
   Zhang, Hao
   Jiang, Li
   Zhang, Guixi
   Qin, Mali
   Pan, Yiheng
   Wen, Xiumei
   Chan, Fion Siu Yin
   Fan, Joe King Man
TI Mesh-preservation approach to treatment of mesh infection after large
   incisional ventral hernia repair-how I do it
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Large incisional hernia; mesh infection; mesh-preservation
ID SURGERY
AB Mesh infection after large incisional ventral hernia repair is a clinical dilemma in abdominal wall hernia surgery. It is believed foreign material should be removed but it causes secondary trauma to the abdominal wall tissue and might be associated with a higher risk of complications. Currently, there is no consensus on mesh-preservation treatment in cases of mesh infection after hernia repair in general. Herein we present the case of a 27-year-old male who recovered well from mesh infection after large incisional ventral hernia repair by mesh-preservation approach. The path to success is choice of material of prosthetic mesh; surgical approach of hernia repair, sufficient wound irrigation and drainage, and acquiring sterility of the mesh surface by wound care techniques such as local iodophor packing and vacuum sealing drainage. Clinical cohorts are needed to verify the feasibility of mesh-preservation treatment of mesh infection after large incisional hernia repair.
C1 [Yang, Xuefei; Aihemaiti, Maimaiti; Zhang, Hao; Jiang, Li; Zhang, Guixi; Qin, Mali; Pan, Yiheng; Wen, Xiumei; Chan, Fion Siu Yin; Fan, Joe King Man] Univ Hong Kong, Shenzhen Hosp, Dept Surg, 1 Haiyuan 1st Rd, Shenzhen 518053, Guangdong, Peoples R China.
   [Chan, Fion Siu Yin; Fan, Joe King Man] Univ Hong Kong, Dept Surg, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong
RP Fan, JKM (通讯作者)，Univ Hong Kong, Shenzhen Hosp, Dept Surg, 1 Haiyuan 1st Rd, Shenzhen 518053, Guangdong, Peoples R China.
EM drjoefan@hku.hk
CR Bikhchandani Jai, 2013, Adv Surg, V47, P1
   Bueno-Lledó J, 2017, AM J SURG, V214, P47, DOI 10.1016/j.amjsurg.2016.10.022
   Hanna M, 2015, HERNIA, V19, P339, DOI 10.1007/s10029-014-1330-9
   Helgstrand F, 2013, J AM COLL SURGEONS, V216, P217, DOI 10.1016/j.jamcollsurg.2012.10.013
   Kao AM, 2018, PLAST RECONSTR SURG, V142, p149S, DOI 10.1097/PRS.0000000000004871
   Kokotovic D, 2016, JAMA-J AM MED ASSOC, V316, P1575, DOI 10.1001/jama.2016.15217
   Liu FD, 2015, GENET MOL RES, V14, P14387, DOI 10.4238/2015.November.18.2
   Mathes T, 2016, WORLD J SURG, V40, P826, DOI 10.1007/s00268-015-3311-2
   Meagher H, 2015, HERNIA, V19, P231, DOI 10.1007/s10029-013-1069-8
   Muysoms FE, 2009, HERNIA, V13, P407, DOI 10.1007/s10029-009-0518-x
   Nobaek S, 2017, SCAND J SURG, V106, P285, DOI 10.1177/1457496917690966
NR 11
TC 4
Z9 7
U1 0
U2 6
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD NOV
PY 2019
VL 7
IS 22
AR 698
DI 10.21037/atm.2019.10.82
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA JS7BX
UT WOS:000500459400088
PM 31930099
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU McGraw, C
   Carrick, M
   Ekengren, F
   Berg, G
   Lieser, M
   Orlando, A
   Madayag, R
   Tanner, A
   Kelly, M
   Banton, K
   Bar-Or, D
AF McGraw, Constance
   Carrick, Matthew
   Ekengren, Francie
   Berg, Gina
   Lieser, Mark
   Orlando, Alessandro
   Madayag, Robert
   Tanner, Allen
   Kelly, Michael
   Banton, Kaysie
   Bar-Or, David
TI Severe fungal infections following blunt traumatic injuries: A 5-year
   multicenter descriptive study
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Post-traumatic; Fungal infection; Blunt trauma; Risk factors; Management
ID CUTANEOUS MUCORMYCOSIS; WOUND INFECTIONS; EPIDEMIOLOGY; SECONDARY;
   FRANCE
AB Introduction: The aggressive and timely treatment of post-traumatic fungal infections is the most efficacious way to reduce morbidity and mortality. Compared to the military trauma population, studies reporting on fungal infections in civilian trauma are not well described. The purpose of this study was to describe characteristics of civilian trauma patients who developed fungal infections and to identify common risk factors and report any delays between injury and treatment.
   Methods: This was a five-year (1/1/2013-3/1/2018) retrospective, descriptive study across six level 1 trauma centers. All consecutively admitted trauma patients (>= 18 years) with laboratory-confirmed fungal wound infections were included. Patients with solely candida wound isolates were excluded. Patient demographics, clinical wound and infection characteristics, organisms cultured, treatment modalities, length of stay, in-hospital mortality, and any diagnostic or treatment delays were described.
   Results: Of the 54,521 trauma patients screened for fungal infection, 12 were identified. All patients suffered major injuries after blunt trauma (abbreviated injury score 3-5) and sustained wound contamination, and in nine patients, the cause of injury was motor vehicle. Six had open wounds/fractures on admission. The geographical region with the highest rate of fungal infection was Texas (n = 7), followed by Kansas (N = 3), then Missouri (N = 2). First symptoms of infection (leukocytosis or fever (n = 10)) presented a median of 6.3 (4.1-9.8) days after injury. Wound management entailed a combination of debridements (n = 8), negative pressure wound therapy (n = 9), amputation (n = 6), and antifungal treatment (n = 10). All fungal isolates identified from the wound site were hyphomycetes. A median of 2.1 (1.8-4.0) days passed from diagnosis to first antifungal treatment, and 3 patients died.
   Conclusions: Our study shows the challenges surrounding diagnosis and treatment of fungal infections secondary to trauma. Non-specific fungal infection symptoms, such as leukocytosis and fever, typically presented a week after injury. Vigilance for investigating risk factors and infection symptoms may help clinicians with more timely management of trauma patients with a severe fungal infection. (C) 2019 Elsevier Ltd. All rights reserved.
C1 [McGraw, Constance; Carrick, Matthew; Orlando, Alessandro; Bar-Or, David] Med City Plano, Trauma Res Dept, Plano, TX USA.
   [McGraw, Constance; Ekengren, Francie; Berg, Gina; Orlando, Alessandro; Bar-Or, David] Wesley Med Ctr, Trauma Res Dept, Wichita, KS USA.
   [McGraw, Constance; Lieser, Mark; Orlando, Alessandro; Bar-Or, David] Res Med Ctr, Trauma Res Dept, Kansas City, MO USA.
   [McGraw, Constance; Orlando, Alessandro; Madayag, Robert; Bar-Or, David] St Anthony Hosp, Trauma Res Dept, Lakewood, CO USA.
   [McGraw, Constance; Orlando, Alessandro; Tanner, Allen; Kelly, Michael; Bar-Or, David] Penrose Community Hosp, Trauma Res Dept, Colorado Springs, CO USA.
   [McGraw, Constance; Orlando, Alessandro; Banton, Kaysie; Bar-Or, David] Swedish Med Ctr, Trauma Res Dept, 501 E Hampden Ave,Rm 4-454, Englewood, CO 80113 USA.
RP Bar-Or, D (通讯作者)，Swedish Med Ctr, Trauma Res Dept, 501 E Hampden Ave,Rm 4-454, Englewood, CO 80113 USA.
EM davidbme49@gmail.com
RI /AAE-9328-2020
OI McGraw, Constance/0000-0001-5635-0892
FU Medical City Plano; Wesley Medical Center; Research Medical Center;
   Penrose Hospital; St. Anthony Hospital; Swedish Medical Center
FX The study was investigator-initiated. Internal funding was provided by
   all affiliated institutions (Medical City Plano, Wesley Medical Center,
   Research Medical Center, Penrose Hospital, St. Anthony Hospital, and
   Swedish Medical Center).
CR Agency USEP, 2019, MOLD MOLD COURS WHY
   Andresen D, 2005, LANCET, V365, P876, DOI 10.1016/S0140-6736(05)71046-1
   Castrejón-Pérez AD, 2017, AN BRAS DERMATOL, V92, P304
   COCANOUR CS, 1992, J TRAUMA, V32, P12, DOI 10.1097/00005373-199201000-00003
   Fanfair RN, 2012, NEW ENGL J MED, V367, P2214, DOI 10.1056/NEJMoa1204781
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   Haidu S, 2009, INJURY, V40, P548, DOI 10.1016/j.injury.2008.03.034
   Ingram PR, 2014, MED MYCOL, V52, P819, DOI 10.1093/mmy/myu054
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   Lloyd B, 2014, SURG INFECT, V15, P619, DOI 10.1089/sur.2012.245
   Loganathan Senthil, 2018, J Clin Orthop Trauma, V9, pS10, DOI [10.1016/j.jcot.2017.10.005, 10.1016/j.jcot.2017.10.005]
   Obradovic-Tomasev M, 2016, SRP ARK CELOK LEK, V144, P52, DOI 10.2298/SARH1602052O
   Rodriguez C, 2014, J TRAUMA ACUTE CARE, V77, P769, DOI 10.1097/TA.0000000000000438
   Rodriguez CJ, 2018, MIL MED, V183, P142, DOI 10.1093/milmed/usy079
   Rodriguez CJ, 2014, SURG INFECT, V15, P521, DOI 10.1089/sur.2013.123
   Alonso MAS, 2006, CLIN MICROBIOL INFEC, V12, P2, DOI 10.1111/j.1469-0691.2006.01602.x
   Singla K, 2018, INDIAN J CRIT CARE M, V22, P375, DOI 10.4103/ijccm.IJCCM_343_17
   Skiada A, 2011, CLIN MICROBIOL INFEC, V17, P1859, DOI 10.1111/j.1469-0691.2010.03456.x
   Spellberg B, 2005, CLIN MICROBIOL REV, V18, P556, DOI 10.1128/CMR.18.3.556-569.2005
   Vitrat-Hincky V, 2009, SCAND J INFECT DIS, V41, P491, DOI 10.1080/00365540902856537
   Warkentien T, 2012, CLIN INFECT DIS, V55, P1441, DOI 10.1093/cid/cis749
   Warkentien TE, 2015, J CLIN MICROBIOL, V53, P2262, DOI 10.1128/JCM.00835-15
   Weintrob AC, 2015, EPIDEMIOL INFECT, V143, P214, DOI 10.1017/S095026881400051X
   Zahoor B, 2016, INJURY, V47, P1383, DOI 10.1016/j.injury.2016.03.011
NR 26
TC 1
Z9 2
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD DEC
PY 2019
VL 50
IS 12
BP 2234
EP 2239
DI 10.1016/j.injury.2019.10.027
PG 6
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA JS8OR
UT WOS:000500561800013
PM 31630781
DA 2026-07-24
ER
PT J
AU Joubert, C
   Sellier, A
   Morvan, JB
   Beucler, N
   Bordes, J
   Dagain, A
AF Joubert, Christophe
   Sellier, A.
   Morvan, J-B
   Beucler, N.
   Bordes, J.
   Dagain, A.
TI Vacuum-assisted closure (VAC) for craniocerebral wounds in severely
   injured patients: technical note of a damage control procedure
SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS
LA English
DT Article
DE vacuum-assisted closure; penetrating craniocerebral trauma; severe
   traumatic brain injury; damage control; trauma management
ID GUNSHOT WOUNDS; BRAIN; HEAD; MANAGEMENT; SCALP
AB The management of a craniocerebral wound (CCW) remains challenging, particularly in a severely injured patient. Considering the complexity of the multilayer insult and damage control care in an unstable patient, every procedure performed should promptly benefit the patient. We report an illustrative case of a patient with a gunshot wound to the head that resulted in a CCW for which we applied vacuum-assisted closure (VAC) therapy according to damage control principles. We describe the technical approach and discuss the indications, results and technique by considering the literature available. VAC can be used for CCWs, particularly for large defects in selected patients according to clinical and CT evaluations following immediate resuscitation. In severely injured and unstable patients, VAC aims to delay definitive reconstructive and time-consuming treatment. Interestingly, it appears to be a safe treatment based on the previously described-but not exclusively trauma-cases with no secondary cerebrospinal fluid leakage encountered.
C1 [Joubert, Christophe; Sellier, A.; Beucler, N.; Dagain, A.] Mil Teaching Hosp St Anne, Neurosurg, Toulon Armees, France.
   [Morvan, J-B] Mil Teaching Hosp St Anne, Ear Nose Throat & Cervicofacial Surg, Toulon Armee, France.
   [Bordes, J.] HIA St Anne, Anesthesiol & Intens Care Unit, Toulon Armees, France.
RP Joubert, C (通讯作者)，Neurosurg, F-83000 Toulon, France.
EM christophe.joubert@neurochirurgie.fr
RI Morvan, Jean-baptiste/N-7724-2015; Joubert, Christophe/AAU-4807-2020
OI BEUCLER, Nathan/0000-0003-3047-4234; Joubert,
   Christophe/0000-0002-8935-6710
CR Aarabi B, 2001, J TRAUMA, V51, pS3
   Afifi AM, 2010, J CRANIOFAC SURG, V21, P1205, DOI 10.1097/SCS.0b013e3181e17c1e
   Ambrosi PB, 2012, NEUROSURG REV, V35, P429, DOI 10.1007/s10143-012-0377-2
   Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Bordes J, 2017, INJURY, V48, P1047, DOI 10.1016/j.injury.2016.11.023
   Carey ME, 2003, SURG NEUROL, V60, P112, DOI 10.1016/S0090-3019(03)00352-5
   CAVALIERE R, 1988, ACTA NEUROCHIR, V94, P133, DOI 10.1007/BF01435866
   Dagain A, 2018, NEUROSURG FOCUS, V45, DOI 10.3171/2018.9.FOCUS18368
   Dagain A, 2017, WORLD NEUROSURG, V102, P6, DOI 10.1016/j.wneu.2017.02.097
   Hofbauer M, 2010, J TRAUMA, V69, P770, DOI 10.1097/TA.0b013e3181c81d7d
   Kim EK, 2008, J CRANIOFAC SURG, V19, P1577, DOI 10.1097/SCS.0b013e3181897376
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Powers AK, 2013, J NEUROSURG, V118, P302, DOI 10.3171/2012.10.JNS112241
   Prince N, 2015, ANN PLAS SURG, V74, pS218, DOI 10.1097/SAP.0000000000000374
   Satteson ES, 2015, J CRANIOFAC SURG, V26, pE599, DOI 10.1097/SCS.0000000000002047
NR 16
TC 5
Z9 7
U1 0
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0035-8665
EI 2052-0468
J9 J ROY ARMY MED CORPS
JI J. R. Army Med. Corps
PD DEC
PY 2019
VL 165
IS 6
DI 10.1136/jramc-2019-001201
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JT1MJ
UT WOS:000500761800001
PM 30992341
DA 2026-07-24
ER
PT J
AU Ward, MA
   Hassan, T
   Burdick, JS
   Leeds, SG
AF Ward, Marc A.
   Hassan, Tareq
   Burdick, James S.
   Leeds, Steven G.
TI Endoscopic vacuum assisted wound closure (EVAC) device to treat
   esophageal and gastric leaks: assessing time to proficiency and cost
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Endoscopic vacuum assisted closure; Proficiency; Cost utilization;
   Anastomotic leak; Intra-abdominal perforation
ID ANASTOMOTIC LEAKAGE; THERAPY
AB Background Endoluminal vacuum therapy (EVAC) is an emerging procedure used to treat anastomotic leaks and/or perforations that would otherwise require surgery. The aim of this study was to determine time to proficiency in EVAC and the cost effectiveness of the procedure.
   Methods We retrospectively reviewed a prospectively maintained IRB approved database for all patients undergoing EVAC after esophageal and gastric complications between October 2013 and December 2017. Proficiency was determined by obtaining predicted estimates and analyzing the point at which average procedure time plateaued based on case volume. Total cost was calculated based on supplies and location where the procedure was performed.
   Results There were 50 patients (17 males, 33 female), with a mean age of 52.1 years. EVAC was placed in 23 (46%) patients with esophageal injuries and 28 (56%) with gastric injuries. Two advanced endoscopists performed all EVAC procedures in this study (1 surgeon, 1 gastroenterologist). The average procedure time for all patients was 43.5 min and the average wheel in/wheel out time for all patients was 75.6 min. Analysis of the trend based on average procedure times for EVAC revealed that proficiency was obtained after 10 cases. Total cost of the procedure is significantly lower in the GI lab compared to the operating room ($4528 vs. $11889). The majority of EVAC were performed in the GI lab (62%) compared to the operating room (38%).
   Conclusion Successful outcomes in managing anastomotic leaks or intestinal perforations non-operatively has led to an increased interest in EVAC. For advanced endoscopists, time to proficiency is approximately 10 cases. Performing the procedure in the GI lab has a 2.5 reduction in total cost compared to the operating room.
C1 [Ward, Marc A.; Hassan, Tareq; Leeds, Steven G.] Baylor Univ, Med Ctr, Dept Minimally Invas Surg, Dallas, TX 75246 USA.
   [Ward, Marc A.; Leeds, Steven G.] Baylor Scott & White Hlth, Ctr Adv Surg, Dallas, TX 75246 USA.
   [Burdick, James S.] Baylor Univ, Med Ctr, Adv Endoscop Consultants, Dallas, TX USA.
   [Leeds, Steven G.] Baylor Univ, Med Ctr, Div Minimally Invas Surg, 3500 Gaston Ave,1st Floor Roberts Bldg, Dallas, TX 75246 USA.
C3 Baylor University Medical Center; Baylor University; Baylor Scott &
   White Health; Baylor University; Baylor University Medical Center;
   Baylor University Medical Center; Baylor University
RP Leeds, SG (通讯作者)，Baylor Univ, Med Ctr, Dept Minimally Invas Surg, Dallas, TX 75246 USA.; Leeds, SG (通讯作者)，Baylor Scott & White Hlth, Ctr Adv Surg, Dallas, TX 75246 USA.; Leeds, SG (通讯作者)，Baylor Univ, Med Ctr, Div Minimally Invas Surg, 3500 Gaston Ave,1st Floor Roberts Bldg, Dallas, TX 75246 USA.
EM Steven.Leeds@BSWHealth.org
OI Ward, Marc/0000-0002-7147-3994
CR Bludau M, 2018, SURG ENDOSC, V32, P1906, DOI 10.1007/s00464-017-5883-4
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Goenka MK, 2015, WORLD J GASTRO ENDOS, V7, P702, DOI 10.4253/wjge.v7.i7.702
   Leeds SG, 2016, SURG OBES RELAT DIS, V12, P1278, DOI 10.1016/j.soard.2016.01.017
   Leeds SG, 2016, JAMA SURG, V151, P573, DOI 10.1001/jamasurg.2016.0255
   Mencio MA, 2018, SURG ENDOSC, V32, P3349, DOI 10.1007/s00464-018-6055-x
   Pines G, 2018, J LAPAROENDOSC ADV S, V28, P33, DOI 10.1089/lap.2017.0318
   Schniewind B, 2013, SURG ENDOSC, V27, P3883, DOI 10.1007/s00464-013-2998-0
   Szymanski K, 2018, CASE REP SURG, V2018, DOI 10.1155/2018/2494069
   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 11
TC 25
Z9 30
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD DEC
PY 2019
VL 33
IS 12
BP 3970
EP 3975
DI 10.1007/s00464-019-06685-2
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JT4QX
UT WOS:000500976900013
PM 30747284
DA 2026-07-24
ER
PT J
AU Poch, T
   Vidim, T
   Stíchová, M
AF Poch, T.
   Vidim, T.
   Stichova, M.
TI Negative wound pressure therapy in treatment of a pressure ulcer in
   paraplegics
SO CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
LA Czech
DT Article
DE pressure ulcer; paraplegia; negative pressure wound therapy
AB This is a case report about the treatment of a patient with post-traumatic paraplegia and pressure ulcer using negative pressure wound therapy. After treating the septic state of the patient, the necessary necrectomy was performed, which was followed by performing a sigmoideostomy and orchiectomy. Negative pressure wound therapy was then used to clean the defect. Despite the application of low molecular weight heparin, the condition was complicated by pulmonary embolism and subsequent heart failure, resulting in the death of the patient. This case report also documents the financial and time benefits of this treatment in the care of a complicated patient
C1 [Poch, T.; Vidim, T.; Stichova, M.] Oblastni Nemocnice Kolin AS, Ctr Vaskularnich Intervenci, Chirurg, Kolin, Czech Republic.
RP Poch, T (通讯作者)，Oblastni Nemocnice Kolin AS, Ctr Vaskularnich Intervenci, Zizkova 146, Kolin 28002, Czech Republic.
EM tomas.poch@seznam.cz
CR Mrna L, 2015, Rozhl Chir, V94, P329
   Vasícková L, 2018, CESK SLOV NEUROL N, V81, pS38, DOI 10.14735/amcsnn2018S38
NR 2
TC 0
Z9 0
U1 0
U2 8
PU CZECH MEDICAL SOC
PI PRAGUE 2
PA SOKOLSKA 31, PRAGUE 2 120 26, CZECH REPUBLIC
SN 1210-7859
EI 1802-4041
J9 CESK SLOV NEUROL N
JI Cesk. Slov. Neurol. Neurochir.
PY 2019
VL 82
SU 1
BP S26
EP S28
DI 10.14735/amcsnn2019S26
PG 3
WC Neurosciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA JT4SO
UT WOS:000500981300005
DA 2026-07-24
ER
PT J
AU Krejcí, M
   Novotny, T
   Staffa, R
   Jureníková, P
AF Krejci, M.
   Novotny, T.
   Staffa, R.
   Jurenikova, P.
TI The use of negative pressure wound therapy for wound complication
   management after vascular procedures
SO CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
LA Czech
DT Article
DE infection; vascular surgery; negative pressure wound therapy; vascular
   surgical procedure
ID SURGICAL SITE INFECTIONS; GRAFTS
AB Aim: To evaluate the results of negative pressure wound therapy (NPWT) in the management of post-operative wound infections (Szilagyi's classification grade II and III) after elective arterial revascularization. Patients and methods: Retrospective analysis of patients' data. All patients who were treated between 2015 and 2018 using NPWT for wound infections after elective arterial procedures on lower extremities were included. Results: Between 2015 and 2018 a total of 13 patients have been treated using NPWT after elective infrainguinal arterial revascularization. There were nine men and four women of an average age of 72 years. Nine patients were treated for Szilagyi grade II infection (69.2%) and four patients for Szilagyi grade III infection (30.8%). In 11 cases there was an early postoperative infection (84.6%). The most common bacterial agent was Staphylococcus aureus. The minimum follow-up was 12 months. During the follow-up, the patency of arterial reconstructions was 92.3% and in 84.6% complete wound healing was achieved. The treatment success rate in the artificial graft patients' group was 88.9%. Conclusion: NPWT is an effective treatment of wound infections in patients after arterial lower extremity revascularization. The method shows promising results in the management of artificial graft infection as well.
C1 [Krejci, M.; Novotny, T.; Staffa, R.] MU, LF, Chirurg Klin 2, Ctr Cevnich Onemocneni, Brno, Czech Republic.
   [Krejci, M.; Novotny, T.; Staffa, R.] Sv Anny Brne, FN, Brno, Czech Republic.
   [Jurenikova, P.] MU, LF, Katedra Osetrovatelstvi & Porodni Asistence, Brno, Czech Republic.
C3 Masaryk University; St. Anne's University Hospital Brno (FNUSA); St.
   Anne's University Hospital Brno (FNUSA-ICRC); Masaryk University
RP Krejcí, M (通讯作者)，Sv Anny Brne, FN, Ctr Cevnich Onemocneni, Chirurg Klin 2, Pekarska 664-53, Brno 65691, Czech Republic.
EM miroslay.krejci@fnusa.cz
RI Novotny, Tomas/LYO-1198-2024; Krejci, Miroslav/JDW-3906-2023
CR Antalová N, 2018, CESK SLOV NEUROL N, V81, pS23, DOI 10.14735/amcsnn2018S23
   Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Badretdinov I A, 2015, Angiol Sosud Khir, V21, P173
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NR 17
TC 1
Z9 1
U1 1
U2 6
PU CZECH MEDICAL SOC
PI PRAGUE 2
PA SOKOLSKA 31, PRAGUE 2 120 26, CZECH REPUBLIC
SN 1210-7859
EI 1802-4041
J9 CESK SLOV NEUROL N
JI Cesk. Slov. Neurol. Neurochir.
PY 2019
VL 82
SU 1
BP S29
EP S32
DI 10.14735/amcsnn2019S29
PG 4
WC Neurosciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA JT4SO
UT WOS:000500981300006
DA 2026-07-24
ER
PT J
AU Qu, WQ
   Wei, C
   Yu, L
   Deng, Y
   Fu, PF
   Kang, Z
   Zhu, SB
AF Qu, Wenqiang
   Wei, Chi
   Yu, Li
   Deng, Yu
   Fu, Panfeng
   Kang, Zhe
   Zhu, Shaobo
TI Three-Stage Masquelet Technique and One-Stage Reconstruction to Treat
   Foot and Ankle Tuberculosis
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE foot and ankle tuberculosis; 3-stage Masquelet technique; 1-stage
   reconstruction
ID VACUUM SEALING DRAINAGE; CEMENT SPACERS; BONE-CEMENT; LONG; OPERATION;
   OUTCOMES; DEFECTS
AB Background: The purpose of this article was to report the feasibility and effectiveness of 3-stage Masquelet technique and 1-stage operation for different stages of foot and ankle tuberculosis (TB). Methods: Ten consecutive patients with foot and ankle TB were retrospectively analyzed between January 2014 and December 2018. Five patients were treated with the 3-stage Masquelet technique, including thorough debridement with vacuum sealing drainage, implantation of antibiotic cement spacer, and subsequent reconstruction. Five patients were treated with a 1-stage reconstruction. The American Orthopaedic Foot & Ankle Society (AOFAS) and visual analog scale (VAS) pain scores were recorded at the last follow-up. The follow-up was 30.3 +/- 17.8 months. Results: No reactivation of TB was observed in any patients. For the 3-stage operation group, 1 patient developed a distal tibia fracture. The duration of anti-TB therapy was 12.0 +/- 0.8 months. The AOFAS score increased from 39.5 +/- 9.9 preoperatively to 75.3 +/- 7.0 postoperatively (P < .05). The VAS pain score decreased from 6.3 +/- 1.9 to 1.5 +/- 1.3 (P < .05). For the 1-stage operation, 1 patient had wound necrosis. The duration of anti-TB therapy was 13.8 +/- 1.1 months. The AOFAS score increased from 51.8 +/- 15.0 to 81.8 +/- 6.3 (P < .05). The VAS pain score decreased from 5.4 +/- 1.1 to 1.0 +/- 0.7 (P < .05). Conclusions: Three-stage operation was effective for foot and ankle TB with stage IV, sinus tracts or other infections, and 1-stage reconstruction was effective for early-stage TBs.
C1 [Qu, Wenqiang; Wei, Chi; Yu, Li; Deng, Yu; Fu, Panfeng; Kang, Zhe; Zhu, Shaobo] Wuhan Univ, Dept Orthopaed Trauma & Microsurg, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Zhu, SB (通讯作者)，Wuhan Univ, Dept Orthopaed Trauma & Microsurg, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM zhushaobo2000@163.com
RI /I-7203-2018; fu, panfeng/N-8203-2018
OI Qu, Wenqiang/0000-0003-2810-2685
CR Aisenberg GM, 2005, CANCER-AM CANCER SOC, V104, P2882, DOI 10.1002/cncr.21541
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NR 35
TC 6
Z9 9
U1 1
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD MAR
PY 2020
VL 41
IS 3
BP 331
EP 341
AR 1071100719890854
DI 10.1177/1071100719890854
EA DEC 2019
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA KZ3LR
UT WOS:000501159300001
PM 31801382
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Biermann, N
   Geissler, EK
   Brix, E
   Schiltz, D
   Prantl, L
   Kehrer, A
   Taeger, CD
AF Biermann, Niklas
   Geissler, Edward K.
   Brix, Eva
   Schiltz, Daniel
   Prantl, Lukas
   Kehrer, Andreas
   Taeger, Christian D.
TI Oxygen levels during negative pressure wound therapy
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Aerobic; Anaerobic; Negative pressure wound therapy; Oxygen
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; ULCERS
AB Aim of the study: Negative pressure wound therapy (NPWT) has become an established treatment modality when dealing with chronic and infected wounds. The underlying mechanism of action is still under discussion and remains controversial. Evidence exists showing rather hypoxic conditions as the main reason for the positive results and bacterial clearance. In an attempt to further explain the mechanism of action, we investigated oxygen levels within the foam interface of a NPWT device.
   Materials and methods: We used an optical sensor based on the principle of dynamic fluorescence quenching and tested five different commonly available NPWT systems used during our daily clinical routine. All measurements were done in an in vitro experimental design for at least 24 h and multiple vacuum intensities were investigated.
   Results: Oxygen levels decreased as much as 22.8% and the amount of vacuum applied inversely correlated with the oxygen reduction. A stepwise increase in vacuum of 25 mmHg showed a linear mean drop of 2.75% per setting. All devices were able to maintain a constant level of negative pressure, and no significant difference between the various dressings was found (p > 0.05).
   Conclusion: Therefore, oxygen levels are decreased within the foam of NPWT dressings, likely leading to oxygen deprivation effects in the underlying wound tissue.
C1 [Biermann, Niklas; Brix, Eva; Schiltz, Daniel; Prantl, Lukas; Kehrer, Andreas; Taeger, Christian D.] Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, Regensburg, Germany.
   [Geissler, Edward K.] Univ Hosp Regensburg, Dept Surg, Regensburg, Germany.
C3 University of Regensburg; University of Regensburg
RP Taeger, CD (通讯作者)，Univ Hosp Regensburg UKR, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
EM christian.taeger@ukr.de
RI prantl, Lukas/AAM-1848-2021; Kehrer, Andreas/AAC-2483-2021; Schiltz,
   Daniel/HJP-4834-2023; Geissler, Edward/R-4131-2016
OI prantl, Lukas/0000-0003-2454-2499; Kehrer, Andreas/0000-0001-9472-7662;
   Schiltz, Daniel/0000-0003-1096-9336; 
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NR 33
TC 17
Z9 22
U1 0
U2 10
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD NOV
PY 2019
VL 28
IS 4
BP 223
EP 226
DI 10.1016/j.jtv.2019.09.001
PG 4
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA JU0YO
UT WOS:000501405300009
PM 31500929
DA 2026-07-24
ER
PT J
AU Kilpadi, DV
   Olivie, M
AF Kilpadi, Deepak, V
   Olivie, Mariana
TI Evaluation of closed incision negative pressure therapy systems on the
   closure of incisional space model
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE closed incision negative pressure therapy (ciNPT); foam-based ciNPT
   dressings; non-foam-based ciNPT dressings; simulated tissue model;
   negative pressure wound therapy (NPWT)
ID SURGICAL-SITE INFECTIONS; WOUND THERAPY; FINANCIAL IMPACT; MANAGEMENT;
   COMPLICATIONS
AB Objective: The objective of this study was to compare the ability of foam dressing-based and non-foam-based closed incision negative pressure therapy (ciNPT) systems to close isolated incisional deficits in a tissue model.
   Methods: Similarly sized foam-based and non-foam-based absorbent ciNPT dressings were applied to similar to 36cm long, similar to 3mm and similar to 6mm wide simulated incisions in gel sheets covered with drape (n=6 dressings/group/experimental condition spread over three respective therapy units). Changes in incision widths were measured directly or with overlying solid gel sheeting (to mimic tissue resistance), at five equally spaced locations before, immediately upon and one hour after initiating negative pressure using associated therapy units.
   Results: Foam-based ciNPT closed simulated incisions more often than non-foam-based ciNPT in all tested conditions (p<0.05). While foam-based ciNPT almost completely closed the similar to 3mm wide incisional spaces, unlike non-foam-based ciNPT, the biggest differences between the two groups were observed with the similar to 6mm incisional width, which allowed maximal inward-stretching of the appositional faces without complete closure. The additional gel layer blunted closure in both groups, but much more with non-foam-based ciNPT. There was minimal impact of negative pressure duration on these results.
   Conclusion: Foam-based ciNPT closed incisional widths in simulated tissue significantly more compared with non-foam-based ciNPT. Different ciNPT systems should not be considered necessarily equivalent in performance.
C1 [Kilpadi, Deepak, V; Olivie, Mariana] 3M KCI, San Antonio, TX 78249 USA.
RP Kilpadi, DV (通讯作者)，3M KCI, San Antonio, TX 78249 USA.
EM deepak.kilpadi@acelity.com
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NR 34
TC 2
Z9 2
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2019
VL 28
IS 12
BP 850
EP 860
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA JU2TE
UT WOS:000501528100012
PM 31825775
DA 2026-07-24
ER
PT J
AU Wang, YF
   Alnumay, A
   Paradis, T
   Beckett, A
   Fata, P
   Khwaja, K
   Razek, T
   Grushka, J
   Deckelbaum, DL
AF Wang, Yifan
   Alnumay, Abdulaziz
   Paradis, Tiffany
   Beckett, Andrew
   Fata, Paola
   Khwaja, Kosar
   Razek, Tarek
   Grushka, Jeremy
   Deckelbaum, Dan L.
TI Management of Open Abdomen After Trauma Laparotomy: A Comparative
   Analysis of Dynamic Fascial Traction and Negative Pressure Wound Therapy
   Systems
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID OPEN ABDOMINAL WOUNDS; DAMAGE-CONTROL; TEMPORARY CLOSURE; VACUUM;
   FISTULA; SURGERY
AB Background Management of the post-traumatic open abdomen (OA) using negative pressure wound therapy (NPWT) alone is associated with low rates of primary fascial closure. The abdominal reapproximation anchor (ABRA) system exerts dynamic medial fascial traction and may work synergistically with NPWT to facilitate primary fascial closure.
   Methods Patients with an OA following trauma laparotomy between 2009 and 2018 were identified from a prospectively maintained institutional database. Patients treated with ABRA in conjunction with NPWT (ABRA) versus NPWT alone (NPWT) were compared in terms of primary fascial closure rate, number of surgeries to closure, tracheostomy duration, length of stay and incidence of entero-atmospheric fistula. Multivariable linear regression was performed to identify predictors of tracheostomy duration.
   Results We identified 48 patients [ABRA, 12 and NPWT, 36]. The ABRA group was significantly younger (25 vs. 37 years, p=0.027) and included a lower proportion of males (58% vs. 89%, p=0.032). Groups were similar with respect to the incidence of hollow viscus injury, injury severity score and abdominal abbreviated injury score. Compared to the NPWT group, the ABRA group had a significantly higher rate of primary fascial closure (100% vs. 28%, p<0.001), fewer surgeries to abdominal closure (2 vs. 2.5, p=0.023) and shorter duration of tracheostomy (15.5 vs. 36 days, p=0.008). There were no differences in length of stay or incidence of entero-atmospheric fistula. On multivariable linear regression, ABRA placement was an independent predictor of shorter tracheostomy duration, after adjusting for covariates (beta=-0.294, p=0.036).
   Conclusion For the post-traumatic OA, ABRA coupled with NPWT achieves a higher rate of primary fascial closure compared to NPWT alone, while requiring fewer surgeries and a shorter duration of tracheostomy.
C1 [Wang, Yifan; Alnumay, Abdulaziz; Paradis, Tiffany; Beckett, Andrew; Fata, Paola; Khwaja, Kosar; Razek, Tarek; Grushka, Jeremy; Deckelbaum, Dan L.] McGill Univ, Hlth Ctr, Div Trauma Surg, 1650 Cedar Ave,L9-411, Montreal, PQ H3G 1A4, Canada.
   [Razek, Tarek; Deckelbaum, Dan L.] McGill Univ, Ctr Global Surg, Montreal, PQ, Canada.
C3 McGill University; McGill University
RP Deckelbaum, DL (通讯作者)，McGill Univ, Hlth Ctr, Div Trauma Surg, 1650 Cedar Ave,L9-411, Montreal, PQ H3G 1A4, Canada.; Deckelbaum, DL (通讯作者)，McGill Univ, Ctr Global Surg, Montreal, PQ, Canada.
EM dan.deckelbaum@mcgill.ca
RI Alnumay, Abdulaziz/MSZ-2173-2025
OI Alnumay, Abdulaziz/0000-0003-1303-4878; Wang, Yifan/0000-0003-2821-1953
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NR 31
TC 18
Z9 23
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD DEC
PY 2019
VL 43
IS 12
BP 3044
EP 3050
DI 10.1007/s00268-019-05166-w
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JU7BI
UT WOS:000501827500013
PM 31506714
OA Bronze
DA 2026-07-24
ER
PT J
AU Matic, P
   Cejic, D
   Tanaskovic, S
   Unic-Stojanovic, D
   Nenezic, D
   Radak, D
AF Matic, Predrag
   Cejic, Djordje
   Tanaskovic, Slobodan
   Unic-Stojanovic, Dragana
   Nenezic, Dragoslav
   Radak, Djordje
TI Results of simultaneous application of hyperbaric oxygen and negative
   pressure wound therapy in diabetic foot ulcers treatment
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Diabetes mellitus; Foot ulcers; Negative pressure wound therapy;
   Hyperbaric oxygen therapy; Limb revascularization
ID VACUUM-ASSISTED CLOSURE; DOUBLE-BLIND; LOWER-LIMB; AMPUTATION; COST
AB Background The aim of this paper is to determine which therapy gives best results regarding process of healing of diabetic foot ulcers among three proposed: only negative pressure wound therapy, only hyperbaric oxygen therapy, and both when used in conjunction.
   Methods This bicentric prospective study included 60 patients, and they were, consecutively, assigned to one of three groups. The first group consisted of 20 patients who were treated only by hyperbaric oxygen therapy, second group consisted of 20 patients treated with combined hyperbaric oxygen and negative pressure wound therapy, and third group consisted of 20 patients who were treated only by negative pressure wound therapy. In some cases, previous revascularization of lower limb was performed and patients with poor run-off, without possibility to perform revascularization, were excluded from the study.
   Results Patients were predominantly men (56.7%) and mean age was 60.57 years. Majority of patients had ulcers of ischemic origin (45%), in 30% of cases, the reason of foot ulceration was neuropathy, and in 25% of patients, the etiology was combined. During the study, in three patients (5%), minor amputations were observed. Regarding Wagner classification of foot ulcers, most dominant was stage II (chi = 12.618, df = 4, p < 0.05). Statistically significant reduction of wound area was achieved when hyperbaric oxygen and negative pressure wound therapy were used in conjunction comparing to isolated use either of these two modalities of treatment (chi = 116.000, df = 44, p < 0.01).
   Conclusion Our data suggests simultaneous use of hyperbaric oxygen therapy and negative pressure wound therapy in diabetic foot ulcer treatment in order to achieve best results. Of great importance is previous wound debridement and successful limb revascularization.
C1 [Matic, Predrag; Tanaskovic, Slobodan; Unic-Stojanovic, Dragana; Nenezic, Dragoslav; Radak, Djordje] Univ Belgrade, Sch Med, Cardiovasc Inst Dedinje, Belgrade, Serbia.
   [Cejic, Djordje] Dept Phys Med & Rehabil Dr Miroslav Zotovic, Banja Luka, Bosnia & Herceg.
C3 University of Belgrade
RP Matic, P (通讯作者)，Univ Belgrade, Sch Med, Cardiovasc Inst Dedinje, Belgrade, Serbia.
EM pmpmatic@gmail.com
RI Matic, Preag/F-7519-2013
OI Matic, Preag/0000-0002-9043-347X; Tanaskovic,
   Slobodan/0000-0003-4216-6693; Unic-Stojanovic,
   Dragana/0000-0002-7066-6292
CR Abidia A, 2003, EUR J VASC ENDOVASC, V25, P513, DOI 10.1053/ejvs.2002.1911
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NR 17
TC 4
Z9 4
U1 0
U2 19
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD OCT
PY 2019
VL 39
IS 4
BP 654
EP 658
DI 10.1007/s13410-019-00737-y
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JU8EQ
UT WOS:000501903800009
DA 2026-07-24
ER
PT J
AU Chen, M
   Yang, HJ
   Wang, F
   Wang, HS
AF Chen, Mei
   Yang, Haijing
   Wang, Fei
   Wang, Hongsheng
TI Vacuum sealing drainage: A novel treatment method for primary cutaneous
   Mycobacterium intracellulare infection
SO INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
LA English
DT Article
DE Cutaneous; Mycobacterium intracellulare; primary; vacuum sealing
   drainage
ID AVIUM-INTRACELLULARE
AB The incidence of primary cutaneous Mycobacterium intracellulare infection is very low. We report a case of primary cutaneous M. intracellulare infection which presented as painful erythematous swelling of the right upper limb without systemic involvement. A novel technique of vacuum sealing drainage was successfully implemented after antimycobacterial treatment proved ineffective at the end of 3 months. Our technique also revealed some additional practical advantages.
C1 [Chen, Mei; Yang, Haijing; Wang, Fei] Southeast Univ, Zhongda Hosp, Sch Med, Dept Dermatol, Nanjing, Jiangsu, Peoples R China.
   [Wang, Hongsheng] Chinese Acad Med Sci, Inst Dermatol, Dept Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing, Jiangsu, Peoples R China.
   [Wang, Hongsheng] Peking Union Med Coll, Nanjing, Jiangsu, Peoples R China.
C3 Southeast University - China; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Institute of Dermatology - CAMS; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Peking Union
   Medical College
RP Wang, F (通讯作者)，Southeast Univ, Zhongda Hosp, Dept Dermatol, Dingjiaqiao Rd 87, Nanjing 210009, Jiangsu, Peoples R China.
EM ffwangfei@163.com
FU Mycobacteria Laboratory, the Institute of Dermatology, Chinese Academy
   of Medical Sciences and Peking Union Medical College
FX This work was supported by Mycobacteria Laboratory, the Institute of
   Dermatology, Chinese Academy of Medical Sciences and Peking Union
   Medical College.
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NR 15
TC 2
Z9 4
U1 0
U2 18
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0378-6323
EI 0973-3922
J9 INDIAN J DERMATOL VE
JI Indian J. Dermatol. Venereol. Leprol.
PD NOV
PY 2019
VL 85
IS 6
BP 605
EP 608
DI 10.4103/ijdvl.IJDVL_873_17
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA JV0VI
UT WOS:000502085500005
PM 29974888
OA gold
DA 2026-07-24
ER
PT J
AU Kunze, KN
   Hamid, KS
   Lee, S
   Halvorson, JJ
   Earhart, JS
   Bohl, DD
AF Kunze, Kyle N.
   Hamid, Kamran S.
   Lee, Simon
   Halvorson, Jason J.
   Earhart, Jeffrey S.
   Bohl, Daniel D.
TI Negative-Pressure Wound Therapy in Foot and Ankle Surgery
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Review
DE wound vac; negative pressure wound therapy; healing; foot; ankle
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTION; BACTERIAL LOAD; LIMB
   SALVAGE; EXPRESSION; ULCERS; RECONSTRUCTION; MANAGEMENT; FLAPS
AB Negative Pressure Wound Therapy (NPWT) is frequently utilized to manage complex wounds, however its mechanisms of healing remain poorly understood. Changes in growth factor expression, micro- and macro-deformation, blood flow, exudate removal, and bacterial concentration within the wound bed are thought to play a role. NPWT is gaining widespread usage in foot and ankle surgery, including the management of traumatic wounds; diabetic and neuropathic ulcers; wounds left open after debridement for infection or dehiscence; high-risk, closed incisions; tissue grafts and free flaps. This article reviews the rationale for NPWT, its proposed mechanisms of action, and the evidence regarding its clinical applications within the field of foot and ankle surgery.
C1 [Kunze, Kyle N.; Hamid, Kamran S.; Lee, Simon; Bohl, Daniel D.] Rush Univ, Med Ctr, Dept Orthopaed Surg, 1611 W Harrison St,Suite 300, Chicago, IL 60612 USA.
   [Halvorson, Jason J.] Wake Forest Baptist Hlth Ctr, Dept Orthopaed Surg, Winston Salem, NC USA.
   [Earhart, Jeffrey S.] OrthoIllinois, Rockford, IL USA.
C3 Rush University; Wake Forest University; Wake Forest Baptist Medical
   Center
RP Bohl, DD (通讯作者)，Rush Univ, Med Ctr, Dept Orthopaed Surg, 1611 W Harrison St,Suite 300, Chicago, IL 60612 USA.
EM danielbohl@gmail.com
RI Bohl, Daniel/AAI-6828-2020
OI Bohl, Daniel/0000-0002-7599-4244
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NR 57
TC 10
Z9 18
U1 1
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD MAR
PY 2020
VL 41
IS 3
BP 364
EP 372
AR 1071100719892962
DI 10.1177/1071100719892962
EA DEC 2019
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA KZ3LR
UT WOS:000502488500001
PM 31833393
DA 2026-07-24
ER
PT J
AU Halama, D
   Dreilich, R
   Lethaus, B
   Bartella, A
   Pausch, NC
AF Halama, Dirk
   Dreilich, Ruth
   Lethaus, Bernd
   Bartella, Alexander
   Pausch, Niels Christian
TI Donor-site morbidity after harvesting of radial forearm free
   flaps-comparison of vacuum-assisted closure with conventional wound
   care: A randomized controlled trial
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Donor-site morbidity; Healing time; Radial forearm free flap;
   Negative-pressure wound therapy; Vacuum-assisted-closure wound therapy
ID SKIN-GRAFTS; THERAPY; RECONSTRUCTION
AB Introduction: Radial forearm free flaps (RFFF) are often used to replace tissue removed in head and neck surgery. In recent years, many attempts have been made to reduce donor-site morbidity and to prevent common complications such as infection, skin-graft necrosis, tendon exposure and subsequent impairment of hand function. One promising option is the use of vacuum-assisted-closure wound therapy (VAC). The objective of this study was to evaluate the effectiveness of VAC compared with a conventional bolster dressing (CBD).
   Material and methods: A randomized controlled trial was enrolled. Our study was prospective in design and included patients with a skin-grafted forearm defect after harvesting of RFFF. Patients who met the inclusion criteria were randomly assigned into two study arms. The predictor variable was the type of wound therapy (VAC therapy compared with CBD) and the outcome variables were (1) the size of the wound area, (2) wrist movement and (3) grip strength. Outcome variables were assessed 12 days, three weeks and eight weeks after surgery.
   Results: Fifty patients (33 males, mean age 61.7 years [SD 15.5]; 17 females, mean age 54.7 years [SD 10.5]) were included consecutively in the study. Patients in the VAC group experienced a faster postsurgical reduction of wound area and had better wrist movement; nonetheless, the differences between the VAC group and CBD group did not reach statistical significance. In contrast, the recovery of post-surgical grip strength was significantly faster in the VAC group.
   Conclusions: Our study failed to prove that VAC therapy is significantly superior to CBD for all the variable studied. Because VAC therapy has some positive effects, however, we recommend further development of this negative-pressure wound treatment, rather than the termination of its use. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Halama, Dirk; Dreilich, Ruth; Lethaus, Bernd; Bartella, Alexander; Pausch, Niels Christian] Univ Hosp Leipzig, Fac Med, Dept Oral Craniomaxillofacial & Facial Plast Surg, Liebigstr 12, D-04103 Leipzig, Germany.
C3 Leipzig University
RP Pausch, NC (通讯作者)，Univ Hosp Leipzig, Fac Med, Dept Oral Craniomaxillofacial & Facial Plast Surg, Liebigstr 12, D-04103 Leipzig, Germany.
EM niels.pausch@medizin.uni-leipzig.de
RI Lethaus, Bernd/AAC-3091-2021
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NR 38
TC 15
Z9 16
U1 0
U2 7
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD DEC
PY 2019
VL 47
IS 12
BP 1980
EP 1985
DI 10.1016/j.jcms.2019.11.004
PG 6
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA JV8KY
UT WOS:000502610100022
PM 31810850
DA 2026-07-24
ER
PT J
AU Hehr, JD
   Hodson, TS
   West, JM
   Schulz, SA
   Poteet, SJ
   Chandawarkar, RY
   Valerio, IL
AF Hehr, Jason D.
   Hodson, Trevor S.
   West, Julie M.
   Schulz, Steven A.
   Poteet, Stephen J.
   Chandawarkar, Rajiv Y.
   Valerio, Ian L.
TI Instillation negative pressure wound therapy: An effective approach for
   hardware salvage
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE debridement; hardware; infection; negative pressure wound therapy; Vac
   with instillation
ID SOFT-TISSUE RECONSTRUCTION; INFECTIONS; MANAGEMENT; SYSTEM; RISK; HIP
AB Wound infection involving hardware can be notoriously difficult to treat, often requiring the removal of the infected implant. The goal of this study was to determine the utility of instillation negative pressure wound therapy to help eradicate infection and allow for definitive wound closure in patients without removing the infected hardware. A retrospective review was performed on the outcomes of 28 patients who presented with open wounds with exposed or infected hardware and who were treated with a combination of surgical debridement and negative pressure wound therapy with instillation (NPWTi). Eleven patients were treated for infected spinal hardware, 12 for extremity, and 5 for sternal hardware. Twenty-five of 28 (89%) patients had successful retention or replacement of hardware, with clearance of infection and healed wounds. Original hardware was maintained in 17 of 28 (61%) patients. In 11 patients, original hardware was removed, with subsequent replacement in eight of those patients after a clean wound was achieved. Average time to definitive closure was 12.6 days. Average follow-up was 135 days. This series supports NPWTi as an effective adjunct therapy to help expeditiously eradicate hardware infection, allowing for hardware retention.
C1 [Hehr, Jason D.; Hodson, Trevor S.; West, Julie M.; Schulz, Steven A.; Poteet, Stephen J.; Chandawarkar, Rajiv Y.; Valerio, Ian L.] Ohio State Univ, Wexner Med Ctr, Dept Plast Surg, Columbus, OH 43212 USA.
C3 University System of Ohio; Ohio State University
RP Valerio, IL (通讯作者)，Ohio State Univ, Dept Plast Surg, 915 Olentangy River Rd,Ste 2100, Columbus, OH 43212 USA.
EM ian.valerio@osumc.edu
RI Valerio, Ian/F-9161-2017
CR [Anonymous], 2018, PRONTOSAN WOUND IRRI
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NR 35
TC 6
Z9 9
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2020
VL 17
IS 2
BP 387
EP 393
DI 10.1111/iwj.13283
EA DEC 2019
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KR3MH
UT WOS:000503356500001
PM 31858713
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Xu, LQ
   Zhao, XX
   Wang, PX
   Yang, J
   Yang, YM
AF Xu, Li-Qian
   Zhao, Xin-Xiu
   Wang, Pei-Xia
   Yang, Ji
   Yang, Yun-Mei
TI Multidisciplinary treatment of a patient with necrotizing fasciitis
   caused by Staphylococcus aureus: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Necrotizing fasciitis; Surgical debridement; Vacuum sealing drainage;
   Multidisciplinary treatment; Case report
ID DIAGNOSIS; THERAPY
AB BACKGROUND
   Necrotizing fasciitis is a severe bacterial skin infection that spreads quickly and is characterized by extensive necrosis of the deep and superficial fascia resulting in the devascularization and necrosis of associated tissues. Because of high morbidity and mortality, accurate diagnosis and early treatment with adequate antibiotics and surgical intervention are vital. And timely identification and treatment of complications are necessary to improve survival of patient.
   CASE SUMMARY
   We report a case of necrotizing fasciitis caused by Staphylococcus aureus in a patient using high doses of glucocorticoid and suffering from secondary diabetes mellitus. He was admitted to our hospital due to redness and oedema of the lower limbs. After admission, necrotizing fasciitis caused by Staphylococcus aureus was considered, and he was discharged after B-ultrasound drainage and multiple surgical operations. In the process of treatment, multiple organ functions were damaged, but with the help of multi-disciplinary treatment, the patient got better finally.
   CONCLUSION
   The key to successful management of necrotizing fasciitis is an early and accurate diagnosis. The method of using vacuum sealing drainage in postoperative patients can keep the wound dry and clean, reduce infection rate, and promote wound healing. Interdisciplinary collaboration is a vital prerequisite for successful treatment.
C1 [Xu, Li-Qian; Zhao, Xin-Xiu; Wang, Pei-Xia; Yang, Ji; Yang, Yun-Mei] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Geriatr, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Yang, YM (通讯作者)，Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Geriatr, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM 1194070@zju.edu.cn
FU National Key Clinical Specialities in the Twelfth Five-Year Plan
   (Geriatrics Department); China Health Promotion Foundation
FX Supported by National Key Clinical Specialities in the Twelfth Five-Year
   Plan (Geriatrics Department); "Demonstration Base of Clinical Nutrition
   for the Elderly" initiated and sponsored by the China Health Promotion
   Foundation.
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NR 25
TC 4
Z9 4
U1 0
U2 11
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD NOV 6
PY 2019
VL 7
IS 21
BP 3595
EP 3602
DI 10.12998/wjcc.v7.i21.3595
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JX1BK
UT WOS:000503477700021
PM 31750343
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Wei, D
   Zhu, XM
   Chen, YY
   Li, XY
   Chen, YP
   Liu, HY
   Zhang, M
AF Wei, Di
   Zhu, Xiao-Mei
   Chen, Yong-Yi
   Li, Xu-Ying
   Chen, Yu-Pan
   Liu, Hua-Yun
   Zhang, Min
TI Chronic wound biofilms: diagnosis and therapeutic strategies
SO CHINESE MEDICAL JOURNAL
LA English
DT Review
DE Biofilm; Chronic wound; Diagnosis; Therapy
ID DIABETIC FOOT ULCERS; NEGATIVE-PRESSURE; ANTIBACTERIAL ACTIVITY;
   STAPHYLOCOCCUS-AUREUS; DEBRIDEMENT; INFECTIONS; MICROSCOPY; GUIDELINES;
   CARE; SKIN
AB Objective: To review the diagnosis of chronic wound biofilms and discuss current treatment approaches. Data sources: Articles included in this review were obtained from the following databases: Wanfang, China National Knowledge Infrastructure, PubMed, and the Web of Science. We focused on research published before August 2019 with keywords including chronic wound, biofilm, bacterial biofilms, and chronic wound infection. Study selection: Relevant articles were selected by carefully reading the titles and abstracts. Further, different diagnosis and clinical treatment methods for chronic wound biofilm were compared and summarized from the selected published articles. Results: Recent guidelines on medical biofilms stated that approaches such as the use of scanning electron microscopy and confocal laser scanning microscopy are the most reliable types of diagnostic techniques. Further, therapeutic strategies include debridement, negative pressure wound therapy, ultrasound, antibiotic, silver-containing dressing, hyperbaric oxygen therapy, and others. Conclusion: This review provides the identification and management of biofilms, and it can be used as a tool by clinicians for a better understanding of biofilms and translating research to develop best clinical practices.
C1 [Wei, Di; Zhu, Xiao-Mei; Chen, Yu-Pan; Liu, Hua-Yun] Cent S Univ, Hunan Canc Hosp, Dept Wound Ost Continence, Nursing Ctr,Affiliated Canc Hosp,Xiangya Sch Med, 283 Rd Tongzipo, Changsha 410013, Hunan, Peoples R China.
   [Chen, Yong-Yi] Cent S Univ, Hunan Canc Hosp, Dept Hosp Off, Affiliated Canc Hosp,Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.
   [Li, Xu-Ying; Zhang, Min] Cent S Univ, Hunan Canc Hosp, Nursing Dept, Affiliated Canc Hosp,Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University
RP Zhu, XM (通讯作者)，Cent S Univ, Hunan Canc Hosp, Dept Wound Ost Continence, Nursing Ctr,Affiliated Canc Hosp,Xiangya Sch Med, 283 Rd Tongzipo, Changsha 410013, Hunan, Peoples R China.
EM zhuxiaomei@hnca.org.cn
FU Program on Clinical Research Center for Wound Healing in Hunan province
   under the Science and Technology Department of Hunan Province
   [2018SK7005]; Guiding Plan of Clinical Medical Technology Innovation in
   Hunan Province [2018SK50905]; Innovation Platform Program: the
   Introduction of Foreign Intellectual Special in Hunan Province
   [2019YZ3035];  [ZDZX2017ZL-04-HN]
FX This work was supported by grants from the Program on Clinical Research
   Center for Wound Healing in Hunan province funded under the Science and
   Technology Department of Hunan Province (No. 2018SK7005), the Guiding
   Plan of Clinical Medical Technology Innovation in Hunan Province (No.
   2018SK50905), the Innovation Platform Program: the Introduction of
   Foreign Intellectual Special in Hunan Province (No. 2019YZ3035), and
   National Major Special Research (No. ZDZX2017ZL-04-HN).
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NR 81
TC 47
Z9 58
U1 3
U2 90
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0366-6999
EI 2542-5641
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD NOV 20
PY 2019
VL 132
IS 22
BP 2737
EP 2744
DI 10.1097/CM9.0000000000000523
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JX5JD
UT WOS:000503770200013
PM 31725458
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hardee, I
   Wang, V
   Frank, C
   Elwood, D
AF Hardee, Isabel
   Wang, Vivian
   Frank, Charles
   Elwood, David
TI Novel Use of Antibiotic Irrigating Solution in Negative-Pressure Wound
   Therapy for a Chronically Infected Abdominal Wall Biologic Mesh
SO AMERICAN SURGEON
LA English
DT Article
ID INSTILLATION
C1 [Wang, Vivian; Frank, Charles; Elwood, David] Emory Univ, Dept Surg, 1365 Clifton Rd,3300, Atlanta, GA 30322 USA.
   [Hardee, Isabel] Emory Univ, Atlanta, GA 30322 USA.
C3 Emory University; Emory University
RP Elwood, D (通讯作者)，Emory Univ, Dept Surg, 1365 Clifton Rd,3300, Atlanta, GA 30322 USA.
EM david.elwood@emory.edu
OI Wang, Vivian/0000-0002-2957-2454; HARDEE, ISABEL/0000-0002-8318-7522
CR Back DA, 2013, INT WOUND J, V10, P32, DOI 10.1111/iwj.12183
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   Patmo ASP, 2014, ADV WOUND CARE, V3, P383, DOI 10.1089/wound.2013.0510
NR 4
TC 1
Z9 1
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD DEC
PY 2019
VL 85
IS 12
BP E596
EP E598
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JY9RK
UT WOS:000504743000006
PM 31908239
DA 2026-07-24
ER
PT J
AU Esumi, G
   Matsuura, T
   Hayashida, M
   Takahashi, Y
   Yoshimaru, K
   Yanagi, Y
   Wada, M
   Taguchi, T
AF Esumi, Genshiro
   Matsuura, Toshiharu
   Hayashida, Makoto
   Takahashi, Yoshiaki
   Yoshimaru, Koichiro
   Yanagi, Yusuke
   Wada, Mika
   Taguchi, Tomoaki
TI Efficacy of Prophylactic Negative Pressure Wound Therapy After Pediatric
   Liver Transplant
SO EXPERIMENTAL AND CLINICAL TRANSPLANTATION
LA English
DT Article
DE Biliary atresia; Surgical complication; Wound dehiscence
ID VACUUM-ASSISTED CLOSURE; INFECTIONS
AB Objectives: Wound dehiscence is a common surgical complication, especially among pediatric liver transplant recipients in our center. In 2013, we introduced negative pressure wound therapy as a preventive treatment. We herein report the clinical outcomes of this intervention.
   Materials and Methods: We conducted a retrospective review of the 26 pediatric liver transplant recipients in our center since 2011. We excluded 1 girl whose wound could not be closed due to bowel edema. The first 13 of the 25 remaining patients were treated with conventional wound management (conventional group). The latter 12 were treated with prophylactic negative pressure wound therapy (prophylactic group). Incidences of surgical complications and patient characteristics were compared between groups.
   Results: Wound dehiscence occurred in 7 of the 13 patients in the conventional group and 3 of the 12 patients in the prophylactic group. When restricted to dehiscence that required surgical debridement, there were 6 cases in the conventional group and no cases in the prophylactic group. Although background data showed that liver insufficiency in the prophylactic group was more severe, this group had a lower incidence of wound dehiscence (P = .015).
   Conclusions: Prophylactic negative pressure wound therapy is thought to be effective for preventing wound dehiscence among pediatric liver transplant recipients.
C1 [Esumi, Genshiro; Matsuura, Toshiharu; Hayashida, Makoto; Takahashi, Yoshiaki; Yoshimaru, Koichiro; Yanagi, Yusuke; Taguchi, Tomoaki] Kyushu Univ, Grad Sch Med Sci, Dept Pediat Surg, Fukuoka, Fukuoka, Japan.
   [Wada, Mika] Kyushu Univ Hosp, Dept Nursing, Fukuoka, Fukuoka, Japan.
C3 Kyushu University; Kyushu University
RP Esumi, G (通讯作者)，Kyushu Univ, Grad Sch Med Sci, Dept Pediat Surg, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan.
EM esumi@pedsurg.med.kyushu-u.ac.jp
RI Yoshimaru, Koichiro/AAG-9740-2021; Yoshimaru, Koichiro/AAG-9740-2021
OI Esumi, Genshiro/0000-0003-0618-9943; Matsuura,
   Toshiharu/0000-0002-4937-3890; Yoshimaru, Koichiro/0000-0002-8709-7313
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 18
TC 2
Z9 4
U1 0
U2 1
PU BASKENT UNIV
PI ANKARA
PA TASKENT CADDESI NO 77, KAT 4, BAHCELIEVLER, ANKARA, 06490, TURKEY
SN 1304-0855
J9 EXP CLIN TRANSPLANT
JI Exp. Clin. Transplant.
PD JUN
PY 2019
VL 17
IS 3
BP 381
EP 386
DI 10.6002/ect.2018.0076
PG 6
WC Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation
GA JZ1SE
UT WOS:000504883700014
PM 30696394
DA 2026-07-24
ER
PT J
AU Kashyap, S
   Podkovik, S
   Tashjian, V
AF Kashyap, Samir
   Podkovik, Stacey
   Tashjian, Vartan
TI Disseminated intravascular coagulation in spine surgery: illustrative
   case review and the paradigms of management
SO JOURNAL OF NEUROSURGERY-SPINE
LA English
DT Review
DE disseminated intravascular coagulation; factor VIIa; bleeding disorders;
   meningioma; wound VAC; vascular disorders
ID TRAUMA
AB Disseminated intravascular coagulation (DIC) is rarely encountered by spine surgeons outside of deformity or severe trauma cases. The authors report an extraordinarily unique case of refractory DIC after elective resection of multiple en plaque thoracic meningiomas in a patient with neurofibromatosis type 1. A 49-year-old man underwent T1-3 laminoplasty and expansile duraplasty for resection of multiple en plaque meningiomas for thoracic myelopathy. Intraoperatively, the patient was found to be in a state of DIC that did not resolve postoperatively despite massive transfusions of blood products. He required subsequent returns to the operating room due to recurrent epidural hematomas with resulting paraplegia. Ultimately, the wound was left open, and a wound vacuum-assisted closure (VAC) was placed to prevent further returns to the operating room. DIC persisted until the administration of recombinant factor VIIa. In this report, the authors review the mechanisms, subtypes, and approaches to treatment of DIC with a focus on the bleeding subtype. If this subtype is refractory to blood product administration (> 24 hours), recombinant factor VIIa is a safe and effective option. A wound VAC can be safely utilized with exposed dura if deemed necessary by the surgeon; however, the volume and characteristics of the output should be closely monitored. The use of unconventional surgical solutions may provide options to mitigate the morbidity associated with refractory DIC in spine surgery.
C1 [Kashyap, Samir; Podkovik, Stacey] Riverside Univ Hlth Syst, Dept Neurosurg, Riverside, CA USA.
   [Kashyap, Samir; Podkovik, Stacey; Tashjian, Vartan] Kaiser Permanente Fontana Med Ctr, Dept Neurosurg, Fontana, CA USA.
C3 Kaiser Permanente
RP Kashyap, S (通讯作者)，Riverside Univ Hlth Syst, Riverside, CA 92503 USA.
EM skashyap41@gmail.com
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NR 24
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1547-5654
EI 1547-5646
J9 J NEUROSURG-SPINE
JI J. Neurosurg.-Spine
PD JAN
PY 2020
VL 32
IS 1
BP 139
EP 143
DI 10.3171/2019.7.SPINE19756
PG 5
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA JZ3TG
UT WOS:000505023600019
PM 31604327
DA 2026-07-24
ER
PT J
AU Wang, Z
AF Wang, Zheng
TI The effects of vacuum sealing drainage on improving the efficacy of
   reducing wound infection and lower extremity deep venous thrombosis in
   patients with orthopedic trauma
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Vacuum sealing drainage; orthopedic trauma; wound infection; lower
   extremity deep venous thrombosis
ID THERAPY; PREVENTION; RISK
AB Objective: This study aimed to explore the effects of vacuum sealing drainage (VSD) on improving the efficacy of reducing wound infection and lower extremity deep venous thrombosis (LEDVT) in patients with orthopedic trauma. Methods: Altogether 78 patients with orthopedic trauma admitted to our hospital were enrolled and randomized into an experimental group and a control group, with 39 patients each. The patients in the control group were conventionally treated with debridement, dressing change, and anti-infection, while those in the experimental group were treated with VSD based on the control group. Their efficacy, wound healing, wound infection, hospitalization time, anti-infection expenses, and incidence of LEDVT were compared. Results: Compared with those in the control group, the patients in the experimental group had a significantly higher effective rate of treatment (P<0.05), a significantly shorter wound healing time (P<0.05), significantly fewer wound infections (P<0.05), significantly shorter healing times of wound infections (P<0.05), significantly less hospitalization time, dressing change frequency, and anti-infection expenses (P<0.05), and a significantly lower incidence of LEDVT (P<0.05). Conclusion: For patients with orthopedic trauma, VSD is conducive to improving their wound healing rate, and reducing the incidences of wound infection and LEDVT, reducing anti-infection expenses and the economic burden, so it is worthy of clinical promotion.
C1 [Wang, Zheng] Shangrao Peoples Hosp, Dept Orthopaed, 86 Shuyuan Rd, Shangrao 334000, Jiangxi, Peoples R China.
RP Wang, Z (通讯作者)，Shangrao Peoples Hosp, Dept Orthopaed, 86 Shuyuan Rd, Shangrao 334000, Jiangxi, Peoples R China.
EM zhengwang-0903@163.com
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
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NR 24
TC 2
Z9 2
U1 0
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 12
BP 13839
EP 13846
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA JZ4CP
UT WOS:000505049200078
DA 2026-07-24
ER
PT J
AU Kim, PJ
   Applewhite, A
   Dardano, AN
   Fernandez, L
   Hall, K
   McElroy, E
   Mendez-Eastman, S
   Obst, MA
   Thomas, C
   Waddell, L
   Wirth, G
   Téot, L
AF Kim, Paul J.
   Applewhite, Andrew
   Dardano, Anthony N.
   Fernandez, Luis
   Hall, Kimberly
   McElroy, Elizabeth
   Mendez-Eastman, Susan
   Obst, Mary Anne
   Thomas, Casey
   Waddell, Lindsey
   Wirth, Garrett
   Teot, Luc
TI Use of a Novel Foam Dressing With Negative Pressure Wound Therapy and
   Instillation: Recommendations and Clinical Experience
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE instillation of topical wound solution; negative pressure wound therapy;
   NPWTi-d; reticulated open-cell foam dressing with through holes;
   ROCF-CC; wound cleansing
ID VACUUM-ASSISTED CLOSURE; COMPLEX WOUNDS; BIOFILM; SCIENCE
AB A new reticulated open-cell foam dressing with through holes (ROCF-CC) has been introduced to assist with wound cleansing by removing thick wound exudate and infectious materials during negative pressure wound therapy with instillation. Due to the limited published evidence supporting use of ROCF-CC dressings with negative pressure wound therapy with instillation and dwell time (NPWTi-d), clinicians have been relying on practical application experience to gain proficiency with the dressing and NPWTi-d. To help provide general guidelines for safe and efficient use of ROCF-CC dressings with NPWTi-d, a multidisciplinary expert panel of clinicians was convened from September 28 to 29, 2017. Principal aims of the meeting were to develop recommendations based on panel members' experience and limited published results for use of ROCF-CC dressings, appropriate wound and patient characteristics for use, application settings, and clinical techniques to optimize outcomes. An algorithm to guide use of ROCF-CC dressings with NPWTi-d was also created. Panelists recommended the following goals for using ROCF-CC dressings: cleanse wounds when areas of slough or nonviable tissue remain on the wound surface, remove thick exudate, remove infectious materials, promote granulation tissue formation, and help provide a bridge to a defined endpoint. Negative pressure wound therapy with instillation and dwell time with ROCF-CC dressings may be an appropriate adjunct therapy for wound cleansing, especially in cases when sharp excisional debridement is not available or appropriate. All panel members agreed that controlled clinical and scientific studies of NPWTi-d with ROCF-CC are needed to further elucidate best practices and effectiveness in various wound types.
C1 [Kim, Paul J.] MedStar Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
   [Applewhite, Andrew] Baylor Univ, Med Ctr, Comprehens Wound Ctr, Dallas, TX USA.
   [Dardano, Anthony N.] Florida Atlantic Univ, Dept Surg, Schmidt Coll Med, Boca Raton Community Hosp, Boca Raton, FL 33431 USA.
   [Fernandez, Luis] Christus Trin Mother Frances Hlth Syst, Div Trauma Surg, Surg Crit Care, Acute Care Surg, Tyler, TX USA.
   [Hall, Kimberly] PeaceHlth Med Grp, Springfield, OR USA.
   [McElroy, Elizabeth] Tower Hlth Syst, W Reading, PA USA.
   [Mendez-Eastman, Susan] Nebraska Med Bellevue, Bellevue, NE USA.
   [Obst, Mary Anne] Reg Hosp, St Paul, MN USA.
   [Thomas, Casey] Salt Lake Reg Med Ctr, Surg Serv, Salt Lake City, UT USA.
   [Waddell, Lindsey] Integumetrix, Nashville, TN USA.
   [Wirth, Garrett] Wirth Plast Surg, Newport Beach, CA USA.
   [Teot, Luc] Montpellier Univ Hosp, Plast Surg Wound Healing & Burns, Montpellier, France.
C3 Georgetown University; Baylor University Medical Center; Baylor
   University; State University System of Florida; Florida Atlantic
   University; Universite de Montpellier; CHU de Montpellier
RP Kim, PJ (通讯作者)，Georgetown Univ, Sch Med, Bles Bldg 1st Floor,3800 Reservoir Rd NW, Washington, DC 20007 USA.; Kim, PJ (通讯作者)，MedStar Georgetown Univ Hosp, MedStar Plast & Reconstruct Surg, Res, Bles Bldg 1st Floor,3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM paul.j.kim@gunet.georgetown.edu
RI ; FERNANDEZ, LUIS/O-7657-2019; /AAY-9683-2020
OI , Paul/0000-0002-6186-6890; FERNANDEZ, LUIS/0000-0002-2730-0199; 
CR Allen D, 2014, INT WOUND J, V11, P198, DOI 10.1111/j.1742-481X.2012.01073.x
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   Stronstad R, 2013, J PENTECOSTAL THEOL, V22, P1, DOI 10.1163/17455251-02201001
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NR 29
TC 33
Z9 36
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2018
SU S
BP S1
EP S17
PG 17
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA VI6KG
UT WOS:000505108300001
PM 29723142
DA 2026-07-24
ER
PT J
AU Tettelbach, W
   Arnold, J
   Aviles, A
   Barrett, C
   Bhatia, A
   Desvigne, M
   Gould, LJ
   Speyrer, MS
   Suski, M
   Traynor, CJ
   Vlad, L
AF Tettelbach, William
   Arnold, Jonathan
   Aviles, Alberto
   Barrett, Christopher
   Bhatia, Animesh
   Desvigne, Michael
   Gould, Lisa J.
   Speyrer, Marcus S.
   Suski, Mark
   Traynor, Colin J.
   Vlad, Lucian
TI Use of Mechanically Powered Disposable Negative Pressure Wound Therapy:
   Recommendations and Reimbursement Update
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; disposable negative pressure wound
   therapy; reimbursement; recommendations
ID MULTICENTER; CARE; SYSTEM
AB Use of ultra-portable, mechanically powered disposable negative pressure wound therapy (dNPWT) has grown as an adjunctive modality to manage wounds in outpatient care and to expedite transition of inpatients to an outpatient setting. This technology has demonstrated similar efficacy and usability for mobile outpatients when compared with electrically powered negative pressure wound therapy devices. It was designed for patients with smaller, low to moderately exudating wounds and does not require batteries or a power source. However, very few studies address best practices for using dNPWT in a variety of wound types. There is a need for comprehensive clinical recommendations to better direct clinicians and patients in using this therapy. In addition, it is critical that providers are knowledgeable about processes for obtaining reimbursement for placement of dNPWT since codes and procedures differ drastically from standard NPWT. A panel meeting of experts with a high level of experience with dNPWT in varied wound types was convened to develop clinical recommendations and summarize current US reimbursement coding guidelines for the use of dNPWT. This publication summarizes the recommendations from panel members, in addition to supporting evidence, to help guide appropriate use of dNPWT. Panel recommendations regarding optimal patient and wound selection, wound preparation, proper patient training, and use of dNPWT in various wound types are included as well as clinical techniques for dressing application, bridging under offloading devices and compression, maintaining a seal, and protecting intact skin. Processes and codes for obtaining reimbursement for dNPWT are reviewed by care setting. Clinical recommendations and reimbursement guidelines summarized in this publication are meant to provide direction to clinicians in using dNPWT that potentially could translate into improved clinical and economic value.
C1 [Tettelbach, William] Landmark Hosp, Salt Lake City, UT USA.
   [Arnold, Jonathan] Mercy Med Ctr, Healing Ctr, Cedar Rapids, IA USA.
   [Aviles, Alberto] Ascens Providence Pk Wound & Hyperbar Med, Novi, MI USA.
   [Barrett, Christopher] Crozer Keystone Ctr Wound Healing, Springfield, PA USA.
   [Bhatia, Animesh] Columbus Podiatry & Surg Inc, Columbus, OH USA.
   [Desvigne, Michael] Valley Wound Care Specialists, Glendale, AZ USA.
   [Gould, Lisa J.] South Shore Hlth Ctr Wound Healing, Weymouth, MA USA.
   [Speyrer, Marcus S.] Wound Treatment Ctr LLC, Opelousas Gen Hlth Syst, Opelousas, LA USA.
   [Suski, Mark] Los Robles Hosp, Thousand Oaks, CA USA.
   [Traynor, Colin J.] St Marys Hosp, San Francisco, CA USA.
   [Vlad, Lucian] Wake Forest Baptist Hlth, Wound Care & Hyperbar Ctr, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Tettelbach, W (通讯作者)，Landmark Hosp Salt Lake City, Wound Care & Infect Prevent, UT 4252 Birkhill Blvd, Murray, UT 84107 USA.
RI Tettelbach, William/T-8356-2019
CR Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
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NR 23
TC 7
Z9 7
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2019
SU S
PG 17
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA JZ4YE
UT WOS:000505108500001
DA 2026-07-24
ER
PT J
AU White, BM
   Meyer, DL
   Harlin, SL
AF White, Brad M.
   Meyer, Dustin L.
   Harlin, Stephen L.
TI Is Negative-Pressure Wound Therapy a "Bridge to Reconstruction" for
   Poststernotomy Mediastinitis? A Systematic Review
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Review
DE complications; flap reconstruction; mediastinitis; negative-pressure
   wound therapy; sternal wounds; sternotomy; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; INFECTIONS;
   EXPERIENCE; MORTALITY; SURGERY
AB OBJECTIVE: To assess the efficacy of negative-pressure wound therapy (NPWT) in preparing sternal wounds for flap reconstruction. METHODS: Investigators searched standard research databases with terms including "post-sternotomy mediastinitis," "deep sternal wound infection," "negative pressure wound therapy," "vacuum assisted closure," and "VAC." Of 434 reports, 14 studies described patients diagnosed with poststernotomy mediastinitis who underwent NPWT followed by flap reconstruction. Eligible studies were assessed for length of stay, mortality, manufacturer involvement, and methodological rigor. MAIN RESULTS: Among a total 429 patients, median length of stay was 29 (+/- 16) days. There were 41 deaths in this inpatient group (10%). Seventy-one percent of the reports were nonrandomized, and 36% of the studies accurately accounted for baseline differences in severity, whereas 14% failed to report diagnostic criteria. Only one study reported follow-up results. Nine studies (64%) failed to make a statement regarding conflicts of interest. In this analysis of quality, 48% (n = 8) of the studies were of very low to low quality. One study was of high quality. CONCLUSIONS: Investigators failed to find ample support for routine use of NPWT as a "bridge to reconstruction." Serious complications related to the use of NPWT including right ventricular rupture, atrial fibrillation, respiratory arrest, recurrent infection, and a retained sponge were reported in this group of studies. Rigorous evaluative studies that assess the true effectiveness of NPWT as a "bridge to reconstruction" must precede its adoption.
C1 [White, Brad M.] Larkin Community Hosp, Miami, FL 33143 USA.
   [Meyer, Dustin L.] Univ S Florida, Morsani Coll Med, Tampa, FL 33620 USA.
   [Harlin, Stephen L.] New Coll Florida, Sarasota, FL USA.
C3 State University System of Florida; University of South Florida; State
   University System of Florida; New College Florida
RP White, BM (通讯作者)，Larkin Community Hosp, Miami, FL 33143 USA.
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
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   De Feo M, 2011, TEX HEART I J, V38, P375
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   De Feo Marisa, 2010, Asian Cardiovasc Thorac Ann, V18, P360, DOI 10.1177/0218492310375854
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   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
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   Food and Drug Administration, 2014, UPDATE SER COMPL ASS
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   Karian Laurel, 2013, Eplasty, V13, pic33
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   West S, 2002, Evid Rep Technol Assess (Summ), P1
NR 27
TC 4
Z9 4
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2019
VL 32
IS 11
BP 502
EP 506
DI 10.1097/01.ASW.0000569120.36663.34
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA JZ6OD
UT WOS:000505222100006
PM 31361268
OA hybrid
DA 2026-07-24
ER
PT J
AU Chou, PR
   Wu, SH
   Hsieh, MC
   Huang, SH
AF Chou, Ping-Ruey
   Wu, Sheng-Hua
   Hsieh, Meng-Chien
   Huang, Shu-Hung
TI Retrospective Study on the Clinical Superiority of the Vacuum-Assisted
   Closure System with a Silicon-Based Dressing over the Conventional
   Tie-over Bolster Technique in Skin Graft Fixation
SO MEDICINA-LITHUANIA
LA English
DT Article
DE VAC; silicon-based dressing; pain; skin graft
ID PRESSURE WOUND THERAPY; PAIN INTENSITY; CONTACT LAYER; DEVICE; MEPITEL
AB Background and Objectives: The tie-over bolster technique has been conventionally used for skin graft fixation; however, long operative times and postoperative pain are the main disadvantages of this method. In this study, we introduce a new method using vacuum-assisted closure (VAC) with a silicon-based dressing as an alternative for skin graft fixation. This retrospective study aimed to evaluate the clinical effect of the VAC plus silicon-based dressing method and the conventional tie-over bolster technique for skin graft fixation in terms of pain, operative time, and skin graft take rate. Materials and Methods: Sixty patients who underwent skin graft surgery performed by a single surgeon from January 2017 to October 2018 were included in this clinical study. They were divided into two groups based on the type of treatment: tie-over bolster technique and vacuum-assisted closure (VAC), or silicon-based dressing groups. The operative times were recorded twice (during suturing or stapling of the graft and during removal of the dressing) in the two groups; similarly, pain was assessed using a numeric rating scale (NRS) after surgery and during dressing removal. Skin graft take rate was evaluated two weeks after dressing removal. Results: Twenty-six patients who met the eligibility criteria were enrolled into the study and assigned to one of the two groups (n = 13 each). No significant differences in age, gender, and graft area were noted between the two groups of patients. The VAC plus silicon-based dressing group demonstrated higher skin graft take rates (p < 0.05), shorter operation times (p < 0.05), and lower levels of pain (postoperative pain and pain during dressing removal) compared with the tie-over bolster technique group (p < 0.05). Conclusions: These findings indicate that VAC with silicon-based dressing can be used for skin graft fixation due to its superior properties when compared with the conventional method, and can improve the quality of life of patients undergoing skin graft fixation.
C1 [Chou, Ping-Ruey] Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung 807, Taiwan.
   [Wu, Sheng-Hua] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Anesthesiol, Kaohsiung 807, Taiwan.
   [Wu, Sheng-Hua] Kaohsiung Med Univ Hosp, Dept Anesthesiol, Kaohsiung 807, Taiwan.
   [Wu, Sheng-Hua] Kaohsiung Municipal Tatung Hosp, Dept Anesthesiol, Kaohsiung 807, Taiwan.
   [Hsieh, Meng-Chien; Huang, Shu-Hung] Kaohsiung Med Univ Hosp, Dept Surg, Div Plast Surg, Kaohsiung 807, Taiwan.
   [Huang, Shu-Hung] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Surg, Kaohsiung 807, Taiwan.
   [Huang, Shu-Hung] Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University; Kaohsiung Municipal Ta-Tung Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University
RP Huang, SH (通讯作者)，Kaohsiung Med Univ Hosp, Dept Surg, Div Plast Surg, Kaohsiung 807, Taiwan.; Huang, SH (通讯作者)，Kaohsiung Med Univ, Coll Med, Sch Med, Dept Surg, Kaohsiung 807, Taiwan.; Huang, SH (通讯作者)，Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr, Kaohsiung 807, Taiwan.
EM u105025047@gap.kmu.edu.tw; elsawu2@gmail.com; williehsieh@hotmail.com;
   huangsh63@gmail.com
RI Huang, Shu-Hung/AAA-3445-2021
OI Huang, Shu-Hung/0000-0002-2903-1703; Chou, Ping-Ruey/0000-0003-0960-8277
FU Ministry of Science and Technology of Taiwan [107-2314-B-037-063-MY2];
   Ministry of Health and Welfare [MOHW107-TDU-B-212-123006]; Kaohsiung
   Medical University Research Center [KMU-TC108A02]; Childhood Burn
   Foundation of the Republic of China
FX We acknowledge the grant support for this study provided by the Ministry
   of Science and Technology of Taiwan (107-2314-B-037-063-MY2), Ministry
   of Health and Welfare (MOHW107-TDU-B-212-123006), Kaohsiung Medical
   University Research Center (KMU-TC108A02), and Childhood Burn Foundation
   of the Republic of China.
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NR 36
TC 11
Z9 13
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD DEC
PY 2019
VL 55
IS 12
AR 781
DI 10.3390/medicina55120781
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KA3ZW
UT WOS:000505737800022
PM 31842472
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, R
   Thayer, P
   Goldstein, A
   Wagner, WD
AF Wang, Rui
   Thayer, Patrick
   Goldstein, Aaron
   Wagner, William D.
TI Interaction of material stiffness and negative pressure to enhance
   differentiation of bone marrow-derived stem cells and osteoblast
   proliferation
SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
LA English
DT Article
DE bone repair material (BRM); chondroitin sulfate (CS); extracellular
   matrix (ECM); mesenchymal stem cells (MSCs); negative pressure wound
   therapy; poly (octanediol citrate) (POC); type I collagen (COL);
   vacuum-assisted wound closure
ID CHONDROITIN SULFATE; OSTEOGENESIS; EXPRESSION; MECHANISMS; ELASTOMERS;
   SCAFFOLDS; GENES; TIME
AB Negative pressure wound therapy (NPWT) results in improved wound repair and the combined use of NPWT with elastomeric materials may further stimulate and accelerate tissue repair. No firmly established treatment modalities using both NPWT and biomaterials exist for orthopedic application. The goal of this study was to investigate the response of osteoblasts and bone marrow-derived mesenchymal stem cells to negative pressure and to determine whether a newly developed elastic osteomimetic bone repair material (BRM), a blend of type I collagen, chondroitin 6-sulfate, and poly (octanediol citrate) could enhance the osteoblastic phenotype. The results indicate that proliferation and alkaline phosphatase activity of hFOB1.19 osteoblasts were significantly increased with exposure to 12 hr of negative pressure (-125 mmHg). Follow-on studies with rat and human mesenchymal stem cells confirmed that negative pressure enhanced osteoblastic maturation. In addition, a significant interaction of negative pressure and electrospun BRM resulted in increased mRNA expression of alkaline phosphatase, osteopontin, collagen1 alpha 2, and HIF1 alpha, whereas little or no effect on these genes was observed on electrospun collagen or tissue culture plastic. Together, these results suggest that the use of this novel biomaterial, BRM, with NPWT may ultimately translate into a safe and cost-effective clinical application to accelerate bone repair.
C1 [Wang, Rui; Wagner, William D.] Wake Forest Univ, Bowman Gray Sch Med, Plast & Reconstruct Surg, Winston Salem, NC USA.
   [Wang, Rui; Thayer, Patrick; Goldstein, Aaron] Wake Forest Univ, Sch Biomed Engn & Sci, Virginia Tech, Biomed Engn & Sci, Winston Salem, NC USA.
   [Goldstein, Aaron] Virginia Tech, Dept Chem Engn, Blacksburg, VA USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Virginia
   Polytechnic Institute & State University; Wake Forest University;
   Virginia Polytechnic Institute & State University
RP Wagner, WD (通讯作者)，Dept Plast & Reconstruct Surg, 112 Nutr Bldg,Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM wwagner@wakehealth.edu
RI ; /AAA-2005-2021
OI Wagner, William/0000-0002-0405-9953; 
FU Center for Nanotechnology and Molecular Materials of Wake Forest
   University; Plastic and Reconstructive Surgery Department of Wake Forest
   University School of Medicine
FX Center for Nanotechnology and Molecular Materials of Wake Forest
   University; Plastic and Reconstructive Surgery Department of Wake Forest
   University School of Medicine
CR Birdwhistell KE, 2018, J KNEE SURG, V31, P410, DOI 10.1055/s-0037-1603801
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NR 30
TC 9
Z9 11
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-6254
EI 1932-7005
J9 J TISSUE ENG REGEN M
JI J. Tissue Eng. Regen. Med.
PD FEB
PY 2020
VL 14
IS 2
BP 295
EP 305
DI 10.1002/term.2993
EA JAN 2020
PG 11
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
   Biology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Biotechnology & Applied Microbiology; Engineering
GA KN2NG
UT WOS:000506371400001
PM 31845531
DA 2026-07-24
ER
PT J
AU Losa-Palacios, S
   Achaerandio-de Nova, A
   Restrepo-Pérez, M
   Gerónimo-Pardo, M
AF Losa-Palacios, Sergio
   Achaerandio-de Nova, Ainara
   Restrepo-Perez, Marcela
   Geronimo-Pardo, Manuel
TI Uncooperative Patient With an Infected Elbow Osteosynthesis: Alternative
   Management With Topical Sevoflurane
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE osteosynthesis; negative pressure wound therapy; sevoflurane; infection;
   trauma; complication; surgical wound
ID PRESSURE WOUND THERAPY; PROSTHESIS RETENTION; JOINT INFECTION;
   DEBRIDEMENT; CLOSURE; ANTIBIOTICS; LIDOCAINE; NONUNION; IMPACT; ULCER
AB Introduction. Treatment of an infected osteosynthesis is usually a complicated process, with its complexity increasing when unforeseen situations appear. Typically, the therapeutic management of such situations is challenging because they are not anticipated in the medical literature, and physicians have to look for and adapt novel solutions to a specific patient condition. Case Report. A 41-year-old, uncooperative, homeless man presented to the emergency room with a left olecranon fracture. After planned surgery, the surgical wound became infected with methicillin-sensitive Staphylococcus aureus because treatment took place in an unhygienic outpatient hospital setting. The patient refused to remain in the hospital and also failed to complete antibiotic courses prescribed (culture-guided rifampicin 600 mg daily plus levofloxacin soo mg daily). Instead of removing the osteosynthesis material, the infection was treated successfully by repeated applications of 5 mL of sevoflurane into the surgical wound. Subsequently, wound healing was achieved with a combination of a brief course of negative pressure wound therapy (NPWT), use of silver-impregnated dressings, and irrigation of the wound with sevoflurane. Sevoflurane also provided topical analgesic to ameliorate the pain caused by removing the NPWT sponge. Interestingly, despite extremely poor compliance by the patient to all standard treatment regimens, and the clinical decision to retain the implant, the infection was resolved and the fracture consolidated. Conclusions. Local application of sevoflurane in the wound bed appears to exhibit analgesic, antimicrobial, and positive healing effects. It could be a promising alternative treatment to be included as a therapeutic option for wound care.
C1 [Losa-Palacios, Sergio; Achaerandio-de Nova, Ainara; Restrepo-Perez, Marcela] Complejo Hosp Univ Albacete, Dept Orthoped Surg, Albacete, Spain.
   [Geronimo-Pardo, Manuel] Complejo Hosp Univ Albacete, Dept Anesthesiol, Calle Hermanos Falco 37, Albacete 02006, Spain.
RP Gerónimo-Pardo, M (通讯作者)，Complejo Hosp Univ Albacete, Dept Anesthesiol, Calle Hermanos Falco 37, Albacete 02006, Spain.
EM sergepu@hotmail.com
RI Gerónimo Pardo, Manuel/AGD-8316-2022
OI Gerónimo Pardo, Manuel/0000-0001-9911-7572; Achaerandio de Nova,
   Ainara/0000-0002-7663-3977
CR Aboltins C, 2013, INTERN MED J, V43, P810, DOI 10.1111/imj.12174
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NR 35
TC 4
Z9 5
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2019
VL 31
IS 10
BP E68
EP E72
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KB9XQ
UT WOS:000506841400002
PM 31730517
DA 2026-07-24
ER
PT J
AU Li, YM
   Wu, B
   Liu, YC
AF Li, Yaomin
   Wu, Bei
   Liu, Yancheng
TI The Effect of Negative Pressure Therapy on Closed Wound After the
   Orthopedic Surgery of Lower Limb: A Meta-Analysis
SO SURGICAL INNOVATION
LA English
DT Article
DE negative pressure therapy; lower limb; orthopedic surgery
ID SURGICAL SITE; PRIMARY HIP; INCISION; KNEE; DRESSINGS; ARTHROPLASTY;
   INFECTION; COMPLICATIONS
AB Background. Negative-pressure wound therapy is applied increasingly to manage closed wounds. However, no consensus has been reached with regard to surgical site infection and wound complication. Aim. To evaluate the effect of negative pressure therapy on closed wounds after orthopedic surgeries. Methods. PubMed, EMBASE, Cochrane Library, and MEDLINE databases were searched from 1966 to January 2019; the references in the identified studies were also searched. Results. Ten studies on arthroplasty and 3 studies on fractures were included. Significantly few infections appeared in the negative pressure group (odds ratio [OR] = 0.28, 95% confidence interval [CI] = 0.18-0.46, P < .001; I-2 = 0%, P = .80). There was no significant difference for other complications (OR = 0.54, 95% CI = 0.21-1.39, P = .20; I-2 = 81%, P < .001). Few patients needed reoperation in the negative pressure group (OR = 0.28, 95% CI = 0.14-0.53, P < .001; I-2 = 0%, P = .82). Conclusion. Negative pressure therapy can decrease surgical site infection and reoperation of closed incisions.
C1 [Li, Yaomin; Wu, Bei; Liu, Yancheng] Tianjin Hosp, Tianjin, Peoples R China.
C3 Tianjin University
RP Li, YM (通讯作者)，Tianjin Hosp, Dept Rehabil, 406 Jiefangnan Rd, Tianjin 300211, Peoples R China.
EM dryaominli@163.com
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NR 19
TC 7
Z9 7
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD APR
PY 2020
VL 27
IS 2
BP 165
EP 172
AR 1553350619893222
DI 10.1177/1553350619893222
EA DEC 2019
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KR8AK
UT WOS:000507040900001
PM 31874595
DA 2026-07-24
ER
PT J
AU Kim, PJ
   Attinger, CE
   Constantine, T
   Crist, BD
   Faust, E
   Hirche, CR
   Lavery, LA
   Messina, VJ
   Ohura, N
   Punch, LJ
   Wirth, GA
   Younis, I
   Teot, L
AF Kim, Paul J.
   Attinger, Christopher E.
   Constantine, Thomas
   Crist, Brett D.
   Faust, Elizabeth
   Hirche, Christoph R.
   Lavery, Lawrence A.
   Messina, Valerie J.
   Ohura, Norihiko
   Punch, Laurie J.
   Wirth, Garrett A.
   Younis, Ibby
   Teot, Luc
TI Negative pressure wound therapy with instillation: International
   consensus guidelines update
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE NPWTi; topical wound solution; wound bioburden; wound cleansing; V; A;
   C; Veraflo therapy
AB The use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) has gained wider adoption and interest due in part to the increasing complexity of wounds and patient conditions. Best practices for the use of NPWTi-d have shifted in recent years based on a growing body of evidence and expanded worldwide experience with the technology. To better guide the use of NPWTi-d with all dressing and setting configurations, as well as solutions, there is a need to publish updated international consensus guidelines, which were last produced over 6 years ago. An international, multidisciplinary expert panel of clinicians was convened on 22 to 23 February 2019, to assist in developing current recommendations for best practices of the use of NPWTi-d. Principal aims of the meeting were to update recommendations based on panel members' experience and published results regarding topics such as appropriate application settings, topical wound solution selection, and wound and patient characteristics for the use of NPWTi-d with various dressing types. The final consensus recommendations were derived based on greater than 80% agreement among the panellists. The guidelines in this publication represent further refinement of the recommended parameters originally established for the use of NPWTi-d. The authors thank Karen Beach and Ricardo Martinez for their assistance with manuscript preparation.
C1 [Kim, Paul J.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
   [Attinger, Christopher E.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, Washington, DC USA.
   [Constantine, Thomas] Toronto Cosmet Surg Inst, Dept Surg, Toronto, ON, Canada.
   [Crist, Brett D.] Univ Missouri Hlth Care, Dept Orthoped Surg, Columbia, MO USA.
   [Faust, Elizabeth] Tower Hlth Syst, Wound, Ost, W Reading, PA USA.
   [Hirche, Christoph R.] Heidelberg Univ, Dept Hand Plast & Reconstruct Surg, Klin Plast & Handchirurg, Ludwigshafen, Germany.
   [Messina, Valerie J.; Wirth, Garrett A.] MemorialCare Long Beach Med Ctr, Wound Healing Ctr, Long Beach, CA USA.
   [Ohura, Norihiko] Kyorin Univ, Dept Plast & Reconstruct Surg, Sch Med, Tokyo, Japan.
   [Punch, Laurie J.] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA.
   [Younis, Ibby] Royal Free Hosp, Dept Plast Surg, Univ Coll Hosp, London, England.
   [Teot, Luc] Montpellier Univ Hosp, Dept Plast Surg, Montpellier, France.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; Georgetown University; University of Missouri System; University
   of Missouri Columbia; Ruprecht Karls University Heidelberg; Kyorin
   University; Washington University (WUSTL); University of London;
   University College London; Royal Free London NHS Foundation Trust; UCL
   Medical School; Universite de Montpellier; CHU de Montpellier
RP Kim, PJ (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Orthoped Surg, Dept Plast Surg, Dallas, TX 75390 USA.
EM paul.kim@utsouthwestern.edu
RI ; Crist, Brett/AAC-7535-2019
OI Lavery, Lawrence/0000-0002-7920-9952; , Paul/0000-0002-6186-6890; 
CR Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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NR 30
TC 150
Z9 183
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2020
VL 17
IS 1
BP 174
EP 186
DI 10.1111/iwj.13254
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KC9VQ
UT WOS:000507520400022
PM 31667978
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Daldal, I
   Senkoylu, A
AF Daldal, Ismail
   Senkoylu, Alpaslan
TI Strategies of management of deep spinal infection: from irrigation and
   debridement to vacuum-assisted closure treatment
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Review
DE Scoliosis; wound infection; spinal instrumentation; surgical site
   infections
ID SURGICAL SITE INFECTIONS; RISK-FACTORS; WOUND-INFECTION; VANCOMYCIN
   POWDER; FUSION; INSTRUMENTATION; IMPLANT
AB Postoperative surgical site problems (PSSPs) following spinal surgery may lead to patient mortality, increased treatment costs and possible recurrent medical interventions. Despite efforts to reduce spinal surgery-related infection rates, complications are common and significantly increased by patient comorbidities. Since PSSPs occur regardless of deterrent measures, it is essential to distinguish the related risk factors. Different treatment conventions for PSSPs, for example, antibiotic treatment, debridement, soft tissue care and removal of implants have been prescribed with blended outcomes. The utilization of the wound vacuum-assisted closure (VAC) system has gained increasing popularity in the management of deep wound infections after deformity surgery.
C1 [Daldal, Ismail] Lokman Hekim Akay Hosp, Dept Orthopaed & Traumatol, Ankara, Turkey.
   [Senkoylu, Alpaslan] Gazi Univ, Dept Orthopaed & Traumatol, TR-06510 Ankara, Turkey.
C3 Lokman Hekim Hospital; Gazi University
RP Senkoylu, A (通讯作者)，Gazi Univ, Dept Orthopaed & Traumatol, TR-06510 Ankara, Turkey.
EM drsenkoylu@gmail.com
RI daldal, ismail/AAM-3002-2021
CR [Anonymous], 2015, User Guide for the 2015 ACS NSQIP Participant Use Data File (PUF)]
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NR 33
TC 14
Z9 19
U1 0
U2 4
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD JAN
PY 2020
VL 8
IS 2
SI SI
AR 33
DI 10.21037/atm.2019.11.60
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA KD0JJ
UT WOS:000507557700013
PM 32055624
OA Green Published, gold
DA 2026-07-24
ER
PT J
AU Zhang, Fl
   Gu, YC
   Wu, LJ
AF Zhang, Fulian
   Gu, Yuecheng
   Wu, Linjun
TI Skin-stretching device promotes the treatment effect of vacuum sealing
   drainage technique on phases III and IV stress-induced injuries in aged
   patients with chronic critical illness A retrospective study of 70
   patients
SO MEDICINE
LA English
DT Article
DE aged patient; chronic critical illness; skin-stretching device;
   stress-induced injury; vacuum sealing drainage
ID PRESSURE ULCERS; WOUND THERAPY; SYSTEM; MANAGEMENT; CLOSURE; RISK
AB Stress-induced injury is a common complication associated with patients with chronic critical illness (CCI). Skin-stretching device (SSD) and vacuum sealing drainage (VSD) technique are 2 approaches that can facilitate wound healing. In the present study, the effect of the concatenated application of the 2 techniques on the phases III and IV stress-induced injuries in aged patients with CCI was assessed. About 70 patients with CCI with stress-induced injuries were selected from February 2015 to October 2017. The treatment outcomes of the combined method and VSD method were assessed by comparing their clinicopathologic parameters. The results showed that the combined treatment shortened the average healing duration of wounds. Moreover, the total area of pressure sores, incidence of bleeding, bacteria amount, 28-day cure rate, peripheral C-reactive protein (CRP) level, and the hospitalization duration were all significantly improved in patients treated with SSD and VSD. The overall effective rate (97.14%) of patients treated with VSD and SSD was significantly higher than that (77.14%) in patients treated with VSD. The present study showed that the combined application of VSD and SSD improved the treatment outcomes of phases III and IV stress-induced injuries in aged patients with CCI.
C1 [Zhang, Fulian; Gu, Yuecheng; Wu, Linjun] Hangzhou First Peoples Hosp, Dept Intens Care Unit, Hangzhou, Peoples R China.
   [Zhang, Fulian; Gu, Yuecheng; Wu, Linjun] Hangzhou Geriatr Hosp, Dept Intens Care Unit, 469 Shenban Rd, Hangzhou 310022, Zhejiang, Peoples R China.
RP Wu, LJ (通讯作者)，Hangzhou Geriatr Hosp, Dept Intens Care Unit, 469 Shenban Rd, Hangzhou 310022, Zhejiang, Peoples R China.
EM hz_wulinjun@126.com
FU Health Technology Program of Hangzhou [2014A60]
FX The study was supported by Health Technology Program of Hangzhou (No:
   2014A60).
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NR 23
TC 11
Z9 13
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2019
VL 98
IS 47
AR 18027
DI 10.1097/MD.0000000000018027
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KD4VV
UT WOS:000507864900051
PM 31764820
OA Green Published, gold
DA 2026-07-24
ER
PT J
AU Horch, RE
   Ludolph, I
   Müller-Seubert, W
   Zetzmann, K
   Hauck, T
   Arkudas, A
   Geierlehner, A
AF Horch, Raymund E.
   Ludolph, Ingo
   Mueller-Seubert, Wibke
   Zetzmann, Katharina
   Hauck, Theresa
   Arkudas, Andreas
   Geierlehner, Alexander
TI Topical negative-pressure wound therapy: emerging devices and techniques
SO EXPERT REVIEW OF MEDICAL DEVICES
LA English
DT Review
DE Medical device; negative pressure wound therapy; wounds; wound coverage;
   wound management; future applications
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; POST-STERNOTOMY
   MEDIASTINITIS; THICKNESS SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE; TEMPORARY
   TREATMENT; SURGICAL INCISIONS; CONTROLLED-TRIAL; TISSUE PRESSURE;
   DIFFERENT SIZES
AB Introduction: The treatment of chronic wounds constitutes a massive financial burden to society and our health-care system. Therefore, efficient wound care is of great importance to all kinds of medical fields. The implementation and modification of negative-pressure wound therapy can be seen as a major improvement in wound healing. Many different NPWT applications evolved trying to address various wound etiologies. Areas covered: This review aims to give an overview of various NPWT applications, show its effects on wound healing, and discuss future modifications. Expert opinion: NPWT as a delivery device for cold plasma, growth factors, or targeted stem cells to the wound bed and the ability to monitor the inflammatory activity, bacterial load and wound healing factors can be seen as possible future steps to individualized wound care. In addition, it requires high-quality experimental studies to develop the ideal foam in terms of microstructure, pore size, and material properties.
C1 [Horch, Raymund E.; Ludolph, Ingo; Mueller-Seubert, Wibke; Zetzmann, Katharina; Hauck, Theresa; Arkudas, Andreas; Geierlehner, Alexander] Friedrich Alexander Univ Erlangen Nuernberg FAU, Univ Hosp Erlangen, Dept Plast & Hand Surg, Lab Tissue Engn & Regenerat Med, Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Geierlehner, A (通讯作者)，Krankenhausstr 12, D-91054 Erlangen, Bavaria, Germany.
EM alexander.geierlehner@uk-erlangen.de
RI Arkudas, Andreas/AAQ-6745-2021; Horch, Raymund/H-8128-2019
OI Arkudas, Andreas/0000-0002-2473-5816; 
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NR 126
TC 36
Z9 45
U1 1
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1743-4440
EI 1745-2422
J9 EXPERT REV MED DEVIC
JI Expert Rev. Med. Devices
PD FEB 1
PY 2020
VL 17
IS 2
BP 139
EP 148
DI 10.1080/17434440.2020.1714434
EA JAN 2020
PG 10
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA KQ2GL
UT WOS:000508105200001
PM 31920139
DA 2026-07-24
ER
PT J
AU Wang, C
   Zhang, YW
   Qu, H
AF Wang, Cong
   Zhang, Yiwen
   Qu, Hao
TI Negative pressure wound therapy for closed incisions in orthopedic
   trauma surgery: a meta-analysis
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Negative pressure wound therapy; Conventional wound dressings; Surgical
   site infection; Closed incisions; Orthopaedic trauma; Meta-analysis
ID SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED CLOSURE; FRACTURE SURGERY;
   RISK; COMPLICATIONS; MANAGEMENT; IMPACT; HIP
AB Background: This meta-analysis was performed to determine the efficacy of negative pressure wound therapy (NPWT) versus conventional wound dressings for closed incisions in orthopedic trauma surgery.
   Methods: A systematic search was performed in PubMed, Embase, and the Cochrane Library databases. The outcome measures included deep surgical site infection (SSI), superficial SSI; wound dehiscence and length of hospital stay. Cochrane collaboration's tool and the Newcastle-Ottawa Scale (NOS) were used to evaluate literature qualities. Meta-analysis was performed using RevMan 5.3 software.
   Results: A total of 6 studies including 2 randomized controlled trials (RCTs) and 4 cohort studies met our inclusion criteria. NPWT resulted in a significantly lower incidence of deep SSI, superficial SSI, and wound dehiscence than conventional wound dressings. However, no statistically significant difference was found in the length of hospital stay.
   Conclusions: NPWT appeared to be an efficient alternative to help prevent SSIs and wound dehiscence on closed incisions in orthopedic trauma surgery. Rational use of NWPT should be based on the presence of patient's condition and risk factors.
C1 [Wang, Cong; Qu, Hao] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthopaed Surg, Hangzhou 310009, Peoples R China.
   [Zhang, Yiwen] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Operating Room, Hangzhou 310009, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Qu, H (通讯作者)，Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthopaed Surg, Hangzhou 310009, Peoples R China.
EM email@zju.edu.cn
OI Qu, Hao/0000-0001-7633-7097
FU Zhejiang Province Natural Science Foundation of China [LQ19H060003]
FX This work was supported by Zhejiang Province Natural Science Foundation
   of China [Grant NO. LQ19H060003].
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NR 32
TC 32
Z9 39
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD DEC 11
PY 2019
VL 14
IS 1
AR 427
DI 10.1186/s13018-019-1488-z
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA KD8SG
UT WOS:000508132500003
PM 31829217
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Aljomah, AS
   Hammami, MM
AF Aljomah, Ahmed S.
   Hammami, Muhammad M.
TI Circumferential Negative Intermittent Pressure to the Midarm Does Not
   Impair Digital O2 Saturation A Randomized Controlled Study
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE NPWT; negative pressure wound therapy; wound healing; wound management;
   pressure; negative pressure dressings; topical negative pressure
   therapy; vacuum-assisted closure; negative pressure wound therapy;
   negative pressure; VAC; vacuum-assisted closure; wounds
ID WOUND THERAPY
AB Background Circumferential negative pressure wound therapy is commonly used to manage wounds and enhance the healing process. A theoretical concern was recently raised that circumferential negative pressure wound therapy may have a negative effect on perfusion distally. Methods In a randomized study, we applied circumferential negative pressure (125 mm Hg) to the midarm of 13 healthy volunteers through InfoV.A.C. Therapy Unit device. The pressure was applied intermittently (5 minutes on and 2 minutes off) for 9 hours. The same device without negative pressure was applied to the contralateral midarm as control. Bilateral index finger O-2 saturation (Spo(2)) was measured every 30 minutes using digital pulse oximetry. Results Mean (SD) age of the volunteers was 32.2 (9.5) years, and 61.5% were male. Mean (SD) area under the curve from time 0 to 9 hours of Spo(2) was 890.56 (6.69) and 889.71 (6.23) %xh in the intervention and control arms, respectively (P = 0.35). O-2 saturation was >= 94% at all observation times in both arms, and no adverse events were identified. Conclusions Circumferential negative intermittent pressure of 125 mm Hg applied to the midarm of healthy volunteers for 9 hours does not adversely affect digital Spo(2).
C1 [Aljomah, Ahmed S.; Hammami, Muhammad M.] King Faisal Specialist Hosp & Res Ctr, Clin Studies & Empir Ethics Dept, POB 3354,MBC03, Riyadh 11211, Saudi Arabia.
   [Hammami, Muhammad M.] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.
C3 King Faisal Specialist Hospital & Research Center; Alfaisal University
RP Hammami, MM (通讯作者)，King Faisal Specialist Hosp & Res Ctr, Clin Studies & Empir Ethics Dept, POB 3354,MBC03, Riyadh 11211, Saudi Arabia.
EM Muhammad@kfshrc.edu.sa
RI Hammami, Muhammad/B-2405-2019
OI Hammami, Muhammad/0000-0002-0086-5819
FU Department of Clinical Studies and Empirical Ethics, King Faisal
   Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
FX None of the authors have a financial interest in any of the products or
   devices mentioned in this article. This study was completely funded by
   the Department of Clinical Studies and Empirical Ethics, King Faisal
   Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. InfoV.A.
   C. Therapy Unit device (KCI USA, Inc, San Antonio, Texas) was used for
   negative pressure, and Vital Signs Monitor (CASMED 740 vital signs
   monitor; CAS Medical Systems, Branford, Connecticut) used for measuring
   of O<INF>2</INF> saturation.
CR Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Othman Diaa, 2012, Plast Surg Int, V2012, P374398, DOI 10.1155/2012/374398
   Vikatmaa P, 2008, EUR J VASC ENDOVASC, V36, P438, DOI 10.1016/j.ejvs.2008.06.010
NR 7
TC 5
Z9 6
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2020
VL 84
IS 2
BP E7
EP E9
DI 10.1097/SAP.0000000000001966
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KE2IQ
UT WOS:000508382300002
PM 31490239
DA 2026-07-24
ER
PT J
AU Gombert, A
   Dillavou, E
   D'Agostino, R 
   Griffin, L
   Robertson, JM
   Eells, M
AF Gombert, Alexander
   Dillavou, Ellen
   D'Agostino, Ralph, Jr.
   Griffin, Leah
   Robertson, Julie M.
   Eells, Mark
TI A systematic review and meta-analysis of randomized controlled trials
   for the reduction of surgical site infection in closed incision
   management versus standard of care dressings over closed vascular groin
   incisions
SO VASCULAR
LA English
DT Review
DE Meta-analysis; vascular surgery; standard of care; negative pressure
   wound therapy
ID NEGATIVE-PRESSURE THERAPY; WOUND THERAPY; COMPLICATIONS
AB Objective Surgical site infection after groin incision is a common complication and a financial burden to patients and healthcare systems. Closed incision negative pressure therapy (ciNPT) has been associated with decreased surgical site infection rates in published literature. This meta-analysis examines the effect of ciNPT (PREVENA (TM) Incision Management System; KCI, San Antonio, TX) versus traditional postsurgical dressing use in reducing surgical site infection rates over closed groin incisions following vascular surgery. Methods A systematic literature search using PubMed, OVID, EMBASE, and QUOSA was performed on 3 January 2019, by two independent researchers and focused on publications between 1 January 2005 and 31 December 2018. The review conformed to the statement and reporting check list of the Preferred Reporting Items for Systematic Reviews and Meta Analyses. Inclusion criteria included abstract or manuscript written in English, published studies, conference abstracts, randomized controlled trials (RCTs), ciNPT usage over closed groin incisions in vascular surgery, comparison of ciNPT use and traditional dressings, study endpoint/outcome of surgical site infection, and study population of >10. Characteristics of study participants, surgical procedure, type of dressing used, duration of treatment, incidence of surgical site infection, and length of follow-up were extracted. Weighted odds ratios and 95% confidence intervals were calculated to pool study and control groups in each publication for analysis. Treatment effects were combined using Mantel-Haenszel risk ratios, and the Chi-Square test was used to assess heterogeneity. Overall, high-risk patients, normal-risk patients, and Szilagyi I, II, III outcomes were assessed between ciNPT and control groups. The Cochrane Collaboration tool was utilized to assess the risk of bias for all studies included in the analysis. Results A total of 615 articles were identified from the literature search. After removal of excluded studies and duplicates, six RCT studies were available for analysis. In these studies, a total of 362 patients received ciNPT, and 371 patients received traditional dressings (control). Surgical site infection events occurred in 41 ciNPT patients and 107 control patients. The heterogeneity test was nonsignificant (p > 0.05). The overall RCT meta-analysis showed a highly significant effect in favor of ciNPT (OR = 3.06, 95% CI [2.05, 4.58], p < 0.05). High-risk, normal-risk, Szilagyi I, and Szilagyi II meta-analyses were also statistically significant in favor of ciNPT use (p < 0.05). The varying RCT inclusion/exclusion criteria, such as differences in procedure types, and patient populations form the major limitations of this study. Conclusions A statistically significant reduction in the incidence of surgical site infection was seen following ciNPT usage in patients undergoing vascular surgery with groin incisions.
C1 [Gombert, Alexander] Univ Hosp RWTH Aachen, Vasc Ctr Aachen Maastricht, Vasc Surg, Aachen, Germany.
   [Dillavou, Ellen] Duke Univ, Med Ctr, Duke Reg Hosp, Vasc Surg, Durham, NC USA.
   [D'Agostino, Ralph, Jr.] Wake Forest Sch Med, Biostat Sci, Winston Salem, NC 27101 USA.
   [Griffin, Leah; Robertson, Julie M.; Eells, Mark] KCI, San Antonio, TX USA.
C3 RWTH Aachen University; RWTH Aachen University Hospital; Duke
   University; Wake Forest University
RP Gombert, A (通讯作者)，Univ Hosp RWTH Aachen, Dept Vasc Surg, European Vasc Ctr Aachen Maastricht, Pauwelsstr 30, D-52074 Aachen, Germany.
EM agombert@ukaachen.de
RI ; Dagostino, Ralph/C-4060-2017
OI Gombert, Alexander/0000-0002-8451-2913; Dagostino,
   Ralph/0000-0002-3550-8395
CR Arnaoutakis DJ, 2017, J VASC SURG, V65, P1713, DOI 10.1016/j.jvs.2016.12.116
   de Vries FEE, 2017, HERNIA, V21, P583, DOI 10.1007/s10029-017-1620-0
   Engelhardt M, 2018, INT WOUND J, V15, P327, DOI 10.1111/iwj.12848
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   Semsarzadeh NN, 2015, PLAST RECONSTR SURG, V136, P592, DOI 10.1097/PRS.0000000000001519
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NR 21
TC 42
Z9 45
U1 1
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD JUN
PY 2020
VL 28
IS 3
BP 274
EP 284
AR 1708538119890960
DI 10.1177/1708538119890960
EA JAN 2020
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA ME1AK
UT WOS:000508519900001
PM 31955666
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Vallini, V
   Rinaldi, E
   Mangano, L
   Modesti, L
   Ghelardini, P
   Roberts, AT
   Grazi, G
AF Vallini, Valerio
   Rinaldi, Elisabetta
   Mangano, Luciana
   Modesti, Luca
   Ghelardini, Piero
   Roberts, Anna Theresa
   Grazi, Giovanni
TI Multiple subcutaneous haematomas of the legs causing skin necrosis in an
   elderly patient affected by corticosteroid-induced skin atrophy: Case
   report and review of literature
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE compartment syndrome; corticosteroid-induced skin atrophy; porcine
   xenograft; skin necrosis
ID RHEUMATOID-ARTHRITIS; COLLAGEN-METABOLISM; LICHEN-SCLEROSUS;
   GLUCOCORTICOIDS; ABNORMALITIES; INHIBITORS; RECEPTOR; THERAPY; STRIAE
AB Corticosteroid-induced skin atrophy (CISA) consists of a thinning of the skin and subcutaneous tissues, representing the natural consequence of a prolonged glucocorticosteroids use, both systemic as well as topical. It is characterised by the loss of elasticity and skin thickness, associated with an increased skin fragility leading to ecchymoses, haematomas, and steroid purpura. The management of CISA is a challenge for physicians, as the pathology is reversible in a minimal percentage of cases and only after a short topical steroid or low-dose course therapy. Often wounds with large loss of substance represent the more common complication, after a surgical drainage which is often necessary. Skin necrosis with compartment syndrome of a leg is another potential risk for these patients. Here, we report a case of an elderly patient affected by multiple subcutaneous haematomas of the legs causing skin necrosis, arisen after the use of anticoagulants for a deep venous thrombosis. The patient was successfully treated with surgical drainage, negative pressure wound therapy (NPWT), and porcine xenograft with no complications. Finally, we discuss the evidence of the current literature on topic.
C1 [Vallini, Valerio; Rinaldi, Elisabetta; Mangano, Luciana; Ghelardini, Piero; Roberts, Anna Theresa; Grazi, Giovanni] Osped Santa Maria Maddalena, Azienda USL Toscana Nord Ovest, UO Med Interna, Pisa, Toscana, Italy.
   [Modesti, Luca] Osped Felice Lotti, Azienda USL Toscana Nord Ovest, UO Ortopedia, Pisa, Italy.
RP Vallini, V (通讯作者)，Osped Santa Maria Maddalena, Azienda USL Toscana Nord Ovest, UO Med Interna, Pisa, Toscana, Italy.
EM vvallini@gmail.com
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NR 57
TC 3
Z9 6
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2020
VL 17
IS 3
BP 540
EP 546
DI 10.1111/iwj.13312
EA JAN 2020
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LH4PB
UT WOS:000508800300001
PM 31972900
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Lim, K
   Lim, X
   Hong, QT
   Yong, E
   Chandrasekar, S
   Tan, GWL
   Lo, ZWJ
AF Lim, Kai
   Lim, Xuxin
   Hong, Qiantai
   Yong, Enming
   Chandrasekar, Sadhana
   Tan, Glenn W. L.
   Lo, Zhiwen J.
TI Use of home negative pressure wound therapy in peripheral artery disease
   and diabetic limb salvage
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE critical limb ischaemia; diabetic limb salvage; negative pressure wound
   therapy; peripheral arterial disease
ID VACUUM-ASSISTED CLOSURE; AMPUTATIONS; CARE; MULTICENTER; PREDICTORS
AB Use of negative pressure wound therapy (NPWT) in peripheral artery disease (PAD) and diabetic limb salvage (DLS) improves wound healing by providing moist wound conditions, reducing exudate, controlling wound-bed infection, and stimulating granulation. NPWT duration may take several weeks, and home-based NPWT allows patient to recover in the community while minimising risks of prolonged hospitalisation. The aim of this study is to review the use and outcomes of home NPWT in PAD and DLS. The methodology is the retrospective review of patients who were discharged with home NPWT after in-patient PAD revascularisation and DLS debridement or minor amputations. The results included a total of 118 patients who received home NPWT between January 2017 and December 2017. The mean age was 62.8 years with 66% male and 34% female patients. The study population comprised 25% smokers, 98% patients with diabetics, 35% with ischemic heart disease, and 21% with end-stage renal failure (ESRF). Of which, 56% of patients required revascularisation while 31% of patients underwent foot debridement, 48% underwent toe amputations, and 20% underwent forefoot amputations. All patients received in-patient NPWT for a week before being discharged on home NPWT for 4 weeks. Then, 62% received targeted antibiotics regime while 36% received empirical antibiotics on discharge; 60% of patients achieved wound healing on home NPWT, with 9% requiring split-thickness skin graft; 4% required further surgical debridement, 16% required further minor amputation while 20% required major amputation. 9% required further home NPWT extension, with a mean length of 7.1 +/- 4.7 weeks' extension. Overall survival of 1 year was 89%. Risk factors that predict the failure of home NPWT includes subjects with a background of ESRF and wet gangrene on presentation. Home NPWT is a useful adjunct in the management of PAD and DLS foot wounds.
C1 [Lim, Kai; Lim, Xuxin; Hong, Qiantai; Yong, Enming; Chandrasekar, Sadhana; Tan, Glenn W. L.; Lo, Zhiwen J.] Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
C3 Tan Tock Seng Hospital
RP Lo, ZWJ (通讯作者)，Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
EM zhiwen_lo@ttsh.com.sg
RI ; Yong, Enming/LXB-4566-2024
OI LO, ZHIWEN JOSEPH/0000-0003-2289-5266; Chanasekar,
   Sadhana/0000-0002-3650-8020; Hong, Qiantai/0000-0003-1334-7049; Yong,
   Enming/0000-0002-9461-0066
CR Abou-Zamzam AM, 2007, ANN VASC SURG, V21, P458, DOI 10.1016/j.avsg.2006.12.006
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NR 37
TC 9
Z9 11
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2020
VL 17
IS 3
BP 531
EP 539
DI 10.1111/iwj.13307
EA JAN 2020
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LH4PB
UT WOS:000508801200001
PM 31972901
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Okkabaz, N
   Esen, E
   Schwartzberg, DM
   Remzi, FH
   Kirat, HT
AF Okkabaz, Nuri
   Esen, Eren
   Schwartzberg, David M.
   Remzi, Feza H.
   Kirat, Hasan T.
TI Hand-Crafted Endoluminal Vacuum-Assisted Drainage for Anastomotic Leak
   After IPAA
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Society-of-Colon-and-Rectal-Surgeons
CY MAY 03-07, 2019
CL San Diego, CA
SP Amer Soc Colon & Rectal Surg
DE Anastomotic leak; Endoluminal vacuum-assisted closure; Hand crafted;
   Ileal pouch-anal anastomosis; Vacuum-assisted closure
ID POUCH-ANAL ANASTOMOSIS; PROCTOCOLECTOMY; THERAPY
AB INTRODUCTION: The vacuum-assisted drainage has many applications in managing complex wound healing. It quickens the recovery period by its hyperemic effect on the exposed zone, decreasing bacterial colonization, preventing tissue edema, and promoting granulation of the wound. However, its use in anastomotic leak after IPAA is scarcely studied, especially because a proprietary endoluminal vacuum-assisted closure system was removed from the US market. TECHNIQUE: We applied a hand-crafted endoluminal vacuum-assisted closure system using the existing standard wound vacuum-assisted closure supplies to 2 patients who developed an anastomotic leak with a presacral abscess after completion proctectomy with J-pouch construction. RESULTS: We changed the endoluminal vacuum-assisted closure drain every 2 to 3 days, and both patients had substantial improvements in their abscess cavity after the seventh and ninth applications. CONCLUSIONS: Anastomotic leak at the IPAA traditionally takes up to a year to heal, which causes a significant toll on the psychosocial life of the patient and delayed stoma closure. Therefore, we believe that facilitating the healing process by using our hand-crafted endoluminal vacuum-assisted closure drain might provide a great value to patients' quality of life.
C1 [Okkabaz, Nuri] Bagcilar Training & Res Hosp, Dept Surg, Istanbul, Turkey.
   [Esen, Eren; Schwartzberg, David M.; Remzi, Feza H.; Kirat, Hasan T.] NYU, Dept Surg, Langone Med Ctr, New York, NY 10016 USA.
C3 Istanbul Bagcilar Training & Research Hospital; NYU Langone Medical
   Center; New York University
RP Kirat, HT (通讯作者)，NYU Langone Med Ctr, IBD Ctr, 240 East 38th St,23rd Floor, New York, NY 10016 USA.
EM tarik.kirat@nyulangone.org
RI Remzi, Feza/AAE-6584-2022; Okkabaz, Nuri/U-4054-2019; Esen,
   Eren/AAF-3624-2021
CR Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Fazio VW, 2013, ANN SURG, V257, P679, DOI 10.1097/SLA.0b013e31827d99a2
   Gardenbroek TJ, 2015, COLORECTAL DIS, V17, P426, DOI 10.1111/codi.12867
   Kiely JM, 2012, DIS COLON RECTUM, V55, P387, DOI 10.1097/DCR.0b013e318246418e
   PARKS AG, 1978, BMJ-BRIT MED J, V2, P85, DOI 10.1136/bmj.2.6130.85
   Pournaras DJ, 2018, WORLD J SURG, V42, P2507, DOI 10.1007/s00268-018-4463-7
   Remzi FH, 2017, COLORECTAL DIS, V19, P1003, DOI 10.1111/codi.13699
   Rottoli M, 2018, TECH COLOPROCTOL, V22, P223, DOI 10.1007/s10151-018-1762-9
   Weidenhagen R, 2008, Rozhl Chir, V87, P397
NR 9
TC 8
Z9 8
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD OCT
PY 2019
VL 62
IS 10
BP 1259
EP 1262
DI 10.1097/DCR.0000000000001453
PG 4
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology; Surgery
GA KF6CY
UT WOS:000509329000019
PM 31490837
DA 2026-07-24
ER
PT J
AU Struyve, M
   De Vloo, C
   Van Veer, H
   Depypere, L
   Nafteux, P
   Roelandt, P
AF Struyve, M.
   De Vloo, C.
   Van Veer, H.
   Depypere, L.
   Nafteux, P.
   Roelandt, P.
TI Endoscopic vacuum-assisted closure therapy for the treatment of
   oesophageal anastomotic leaks
SO ACTA GASTRO-ENTEROLOGICA BELGICA
LA English
DT Article
DE oesophagus; anastomotic leak; perforation; endoluminal vacuum therapy;
   endoscopic vacuum-assisted closure therapy
ID PERFORATIONS
AB Persisting suture dehiscence with oesophageal anastomotic leaks after thoracic surgery is a difficult complication, especially when a surgical repair fails. We report here endoscopic vacuum-assisted closure therapy as a novel endoscopic treatment for the management of oesophageal anastomotic leaks. Endoscopic vacuum-assisted closure therapy is a minimally invasive method to treat anastomotic leakage by positioning an open-pored polyurethane sponge and a suction tube connected to a wound drainage system into the opening of the wound cavity. This multidisciplinary endoscopic and surgical approach is a successful therapy for the management of suture dehiscence with oesophageal anastomotic leaks after thoracic surgery or oesophageal perforations.
C1 [Struyve, M.; De Vloo, C.; Roelandt, P.] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Gastroenterol & Hepatol, Herestr 49, B-3000 Leuven, Belgium.
   [Struyve, M.] ZOL, Dept Gastroenterol & Hepatol, Genk, Belgium.
   [Van Veer, H.; Depypere, L.; Nafteux, P.] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Thorac Surg, Leuven, Belgium.
C3 KU Leuven; University Hospital Leuven; East Limburg Hospital; KU Leuven;
   University Hospital Leuven
RP Struyve, M (通讯作者)，Katholieke Univ Leuven, Univ Hosp Leuven, Dept Gastroenterol & Hepatol, Herestr 49, B-3000 Leuven, Belgium.
EM mathieustruyve@me.com
RI ; Van Veer, Hans/K-6754-2019
OI Depypere, Lieven/0000-0001-8230-5649; Van Veer,
   Hans/0000-0003-1153-8298; Struyve, Mathieu/0000-0002-6933-3810
CR Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Rogalski P, 2015, WORLD J GASTROENTERO, V21, P10542, DOI 10.3748/wjg.v21.i37.10542
   Schniewind B, 2013, SURG ENDOSC, V27, P3883, DOI 10.1007/s00464-013-2998-0
   Siersema PD, 2005, GASTROINTEST ENDOSC, V61, P897, DOI 10.1016/S0016-5107(05)01589-0
NR 4
TC 2
Z9 4
U1 0
U2 0
PU UNIV CATHOLIQUE LOUVAIN-UCL
PI BRUSSELS
PA CLIN UNIV SAINT LUC, AVE HIPPOCRATE 10, BRUSSELS, B-1200, BELGIUM
SN 1784-3227
J9 ACTA GASTRO-ENT BELG
JI Acta Gastro-Enterol. Belg.
PD OCT-DEC
PY 2019
VL 82
IS 4
BP 529
EP 531
PG 3
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA KF6SS
UT WOS:000509370700009
PM 31950809
DA 2026-07-24
ER
PT J
AU Cocjin, HGB
   Jingco, JKP
   Tumaneng, FDC
   Coruña, JMR
AF Cocjin, Hansel Gould B.
   Jingco, Jair Kimri P.
   Tumaneng, Franklin Delano C.
   Coruna, Jose Maria R.
TI Wound-Healing Following Negative-Pressure Wound Therapy with Use of a
   Locally Developed AquaVac System as Compared with the Vacuum-Assisted
   Closure (VAC) System
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID RANDOMIZED-TRIAL; NPWT; MANAGEMENT; MULTICENTER; EXPERIENCE; PATIENT;
   DEVICE; LEG
AB Background: Negative-pressure wound therapy (NPWT) gained widespread clinical use after its introduction in the 1990s because of its many beneficial effects on the wound environment. However, high treatment costs have limited its use in third-world countries. The present study compares a low-cost, locally developed NPWT system with a commercially available system in terms of efficacy, reliability, ease of application, and safety.
   Methods: This prospective, randomized controlled trial involved 36 patients who were managed with NPWT with either a low-cost, locally developed system (AquaVac) or a commercially available Vacuum-Assisted Closure Advanced Therapy System (VAC ATS; KCI). The low-cost NPWT system described consists of a converted aquarium pump as a reusable vacuum source and a dressing system that can be found in the hospital supply room: food plastic wrap as an occlusive drape, surgical gauze as wound filler, nasogastric tubes as tubing, and used intravenous (IV) bottles as effluent canisters. The purpose of the study was to compare the 2 systems in terms of (1) time to apply the dressing, (2) exudate levels, (3) amount of granulation tissue, (4) wound size reduction, (5) average cost of treatment, (6) visual analog scale (VAS) pain scores, and (7) complications.
   Results: The experimental low-cost system had a small but statistically insignificant advantage over the commercially available system in terms of application time, pain during dressing changes, and wound contraction percentage. The 2 systems were comparable in terms of the amount of exudate, granulation tissue coverage, and VAS scores during the course of treatment. No wound or periwound complications were observed. The systems were significantly different in terms of cost, with the AquaVac system being 7 times less expensive than the VAC ATS system ($63.75 compared with $491.38 USD).
   Conclusions: The low-cost AquaVac system was shown to be comparable with the commercial VAC ATS system, suggesting that it is an effective and safe alternative method for NPWT in resource-challenged settings.
C1 [Cocjin, Hansel Gould B.; Jingco, Jair Kimri P.; Tumaneng, Franklin Delano C.; Coruna, Jose Maria R.] CLMMRH, Bacolod City, Philippines.
   [Cocjin, Hansel Gould B.; Jingco, Jair Kimri P.; Tumaneng, Franklin Delano C.; Coruna, Jose Maria R.] CLMMRH, Dept Orthopaed & Traumatol, Bacolod City, Philippines.
RP Cocjin, HGB (通讯作者)，CLMMRH, Dept Orthopaed & Traumatol, Bacolod City, Philippines.
EM hanselgouldcocjin@gmail.com
OI Cocjin, Hansel Gould/0000-0001-6010-431X
FU Philippine Council for Health Research and Development (PCHRD);
   Department of Science and Technology VI (DOST VI); Western Visayas
   Health Research and Development Consortium (WVHRDC)
FX The study grant was provided by the Philippine Council for Health
   Research and Development (PCHRD) in cooperation with the Department of
   Science and Technology VI (DOST VI) and Western Visayas Health Research
   and Development Consortium (WVHRDC). The funding source did not play a
   role in the investigation.
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NR 63
TC 16
Z9 19
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD NOV 20
PY 2019
VL 101
IS 22
BP 1990
EP 1998
DI 10.2106/JBJS.19.00125
PG 9
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA KG0ZQ
UT WOS:000509671300007
PM 31764361
DA 2026-07-24
ER
PT J
AU Poortmans, N
   Berrevoet, F
AF Poortmans, N.
   Berrevoet, F.
TI Dynamic closure techniques for treatment of an open abdomen: an update
SO HERNIA
LA English
DT Review
DE Open abdomen; Dynamic closure; Negative pressure wound therapy;
   Systematic review
ID MEDIATED FASCIAL TRACTION; TEMPORARY ABDOMINAL CLOSURE; ASSISTED WOUND
   CLOSURE; DELAYED CLOSURE; VACUUM; MANAGEMENT; THERAPY; CLASSIFICATION
AB Background The open abdomen (OA) is an important approach for managing intra-abdominal catastrophes and continues to be the standard of care. Despite this, challenges remain as it is associated with a high incidence of complications and poor outcomes. The objective is to perform a systematic review on dynamic closure techniques for fascial closure during open abdomen management. Methods An electronic database search was conducted involving 4 different databases (MEDLINE (PubMed), SCOPUS, WEB OF SCIENCE (WOS) and EMBASE). All studies that described dynamic closure techniques in OA patients were eligible for inclusion. Data collected were synthesized by each outcome of interest. Results Thirteen studies were included in the final synthesis. Overall methodological quality was low with a high number of retrospective observational studies and low number of patients. All included studies are observational cohort studies. No studies reported on the use of either Wittmann patch, dynamic retention sutures or ABRA system. Two studies reported on the ABRA system in combination with Negative Pressure Wound Therapy (NPWT), while 9 reported on mesh-mediated fascial traction (MMFT) combined with NPWT. Other types of fascial traction, either by dynamic suture lines or by a self-made silastic tube system, and NPWT were reported in 2 studies. Overall closure rates are 93.2% for the ABRA system + NPWT versus 72.0% for the mesh-mediated fascial traction + NPWT. Conclusion Careful selection and good management of OA patients will avoid prolonged treatment and facilitate early fascial closure. Future research should focus on comparison of different temporary dynamic closure techniques to evolve toward best treatment options, in terms of both fascial closure rates and long-term incisional hernia rates.
C1 [Poortmans, N.; Berrevoet, F.] Ghent Univ Hosp, Dept Gen & HPB Surg & Liver Transplantat, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
C3 Ghent University; Ghent University Hospital
RP Berrevoet, F (通讯作者)，Ghent Univ Hosp, Dept Gen & HPB Surg & Liver Transplantat, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
EM Frederik.Berrevoet@UGent.be
RI ; Berrevoet, Frederik/A-6117-2008
OI Poortmans, Natalie/0000-0001-5270-2678; 
CR Acosta S, 2017, EUR J VASC ENDOVASC, V54, P697, DOI 10.1016/j.ejvs.2017.09.002
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NR 32
TC 14
Z9 19
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2020
VL 24
IS 2
SI SI
BP 325
EP 331
DI 10.1007/s10029-020-02130-9
EA FEB 2020
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KW4SU
UT WOS:000511044800002
PM 32020342
OA Green Published
DA 2026-07-24
ER
PT J
AU Bobkiewicz, A
   Borejsza-Wysocki, W
   Krokowicz, L
   Banasiewicz, T
AF Bobkiewicz, Adam
   Borejsza-Wysocki, Wlodzimierz
   Krokowicz, Lukasz
   Banasiewicz, Tomasz
TI LapVac - a laparoscopic approach for negative pressure wound therapy
   application in open abdomen management: a porcine animal model
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Article
DE negative pressure wound therapy; laparoscopy; open abdomen
ID FISTULA; CLOSURE
AB Introduction: Negative pressure wound therapy (NPWT) in the open abdomen (OA) is recognized as a gold standard management method. Currently minimally invasive procedures are implemented in many clinical scenarios.
   Aim: To demonstrate the feasibility of using negative pressure wound therapy in a laparoscopic approach for OA management in a porcine model termed as a laparoscopic vacuum (LapVac).
   Material and methods: An adult female swine underwent a laparoscopic procedure. Briefly, a small incision was made and secured with a wound protector, pneumoperitoneum was created and two additional ports were placed. Then, a non-adhesive layer was precisely placed within the abdominal cavity.
   Results: Finally, polyurethane foam and adhesive drape were applied. A volume of 200 ml of saline solution was instilled and drained completely within 30 min. We did not observe any technical problems with NPWT application.
   Conclusions: This study confirmed the technical feasibility of NPWT application in the laparoscopic approach. LapVac seems to be a promising technique which may minimize the trauma and lead to better outcomes.
C1 [Bobkiewicz, Adam; Borejsza-Wysocki, Wlodzimierz; Krokowicz, Lukasz; Banasiewicz, Tomasz] Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, 49 Przybyszewskiego St, PL-60355 Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Bobkiewicz, A (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, 49 Przybyszewskiego St, PL-60355 Poznan, Poland.
EM bobofon007@gmail.com
CR Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
   Bobkiewicz A, 2017, INT WOUND J, V14, P255, DOI 10.1111/iwj.12597
   Bobkiewicz A, 2015, J LAPAROENDOSC ADV S, V25, P314, DOI 10.1089/lap.2014.0463
   Chiara O, 2016, J TRAUMA ACUTE CARE, V80, P173, DOI 10.1097/TA.0000000000000882
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
   Demetriades D, 2014, SURG CLIN N AM, V94, P131, DOI 10.1016/j.suc.2013.10.010
   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
NR 7
TC 0
Z9 0
U1 0
U2 1
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2020
VL 15
IS 1
BP 112
EP 116
DI 10.5114/wiitm.2019.86829
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KI1RL
UT WOS:000511125300015
PM 32117493
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, HQ
   Liu, XC
   Zheng, GF
   Ye, B
   Chen, WQ
   Xie, HL
   Liu, YQ
   Guo, Y
AF Liu, Hongquan
   Liu, Xiaochun
   Zheng, Guofu
   Ye, Bo
   Chen, Weiqing
   Xie, Hailiang
   Liu, Yunqiang
   Guo, Yi
TI Chronic mesh infection complicated by an enterocutaneous fistula
   successfully treated by infected mesh removal and negative pressure
   wound therapy A case report
SO MEDICINE
LA English
DT Article
DE chronic mesh infection; enterocutaneous fistula; negative pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; HERNIA REPAIR; INCISIONAL HERNIA; SYNTHETIC
   MESH; POLYPROPYLENE; EXPERIENCE; MANAGEMENT
AB Rationale: Tension-free repair of inguinal hernia with prosthetic materials in adults has become a routine surgical procedure. However, serious complications may arise such as mesh displacement, infection, and even enterocutaneous fistula (EF). The management of chronic mesh infection (CMI) complicated by an EF is very challenging. A simple treatment of infected mesh removal and negative pressure wound therapy (NPWT) may cure the patients with EF with CMI.
   Patient concerns: A 75-year-old male patient underwent tension-free treatment for a bilateral inguinal hernia at a county hospital 10 years ago. Three months before admission, the right groin gradually formed a skin sinus with outflow of fetid thin pus, and it could not heal.
   Diagnoses: The patient was diagnosed preoperatively with mesh plug adhesion to the intestine, which resulted in low-flow EF combined with CMI.
   Interventions: The patient received a simple treatment mode consisting of an incision made from the original incision, but the new incision did not penetrate the abdominal cavity; treatment included resection of the fistula, removal of the mesh, repair of the intestine and local tissue, and continuous irrigation of vacuum sealing drainage (VSD) devices for NPWT.
   Outcomes: The infected mesh was completely removed. Five VSD devices were utilized to treat the EF and wound. The time from intervention to wound healing was 35 days, and follow-up for 6 months revealed no infection and no hernia recurrence in the right groin.
   Lessons: The NPWT is effective in treating CMI concomitant with EF and does not increase the risk of hernia recurrence.
C1 [Liu, Hongquan; Liu, Xiaochun; Zheng, Guofu; Ye, Bo; Chen, Weiqing; Xie, Hailiang; Liu, Yunqiang; Guo, Yi] Nanchang Univ, Affiliated Ganzhou Hosp, Ganzhou Peoples Hosp, Dept Gen Surg, Ganzhou 341000, Peoples R China.
C3 Nanchang University
RP Liu, XC (通讯作者)，Nanchang Univ, Affiliated Ganzhou Hosp, Ganzhou Peoples Hosp, Dept Gen Surg, Ganzhou 341000, Peoples R China.
EM lxcmail8@163.com
RI Liu, Xiaochun/O-2518-2017; Guo, Yi/HTP-2507-2023
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NR 37
TC 5
Z9 7
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2019
VL 98
IS 49
AR e18192
DI 10.1097/MD.0000000000018192
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KI5ZL
UT WOS:000511428400057
PM 31804338
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hussamy, DJ
   Wortman, AC
   McIntire, DD
   Leveno, KJ
   Casey, BM
   Roberts, SW
AF Hussamy, Deana J.
   Wortman, Alison C.
   McIntire, Donald D.
   Leveno, Kenneth J.
   Casey, Brian M.
   Roberts, Scott W.
TI Closed Incision Negative Pressure Therapy in Morbidly Obese Women
   Undergoing Cesarean Delivery A Randomized Controlled Trial
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article; Proceedings Paper
CT 38th Annual Pregnancy Meeting of the Society-for-Maternal-Fetal-Medicine
   (SMFM)
CY JAN 28-FEB 03, 2018
CL Dallas, TX
SP Soc Maternal Fetal Med
ID SURGICAL SITE INFECTIONS; WOUND THERAPY; HIGH-RISK; SECTION;
   COMPLICATIONS; MANAGEMENT
AB OBJECTIVE: To evaluate the efficacy of incisional negative pressure wound therapy in the prevention of postoperative wound morbidity in women with class III obesity undergoing cesarean delivery.
   METHODS: In an open label randomized controlled trial, women admitted for delivery with class III obesity (body mass index 40 or higher) measured within 2 weeks of admission for delivery were offered participation in the study. They were consented either in the outpatient maternal-fetal medicine specialty clinic, during admission to labor and delivery and before a decision to perform cesarean delivery, or in the preoperative area of the hospital before scheduled cesarean delivery. Exclusion criteria included anticoagulation therapy, human immunodeficiency virus infection, and silver or acrylic allergy. Those who ultimately underwent cesarean delivery were randomized to standard surgical dressing or incisional negative pressure wound therapy dressing. The primary outcome was wound morbidity. Preplanned secondary outcomes included characteristics of composite wound morbidity, and hospital, emergency room, and clinic utilization. The sample size estimate required randomization of 440 women to detect a 50% decrease in composite outcome.
   RESULTS: Between January 1, 2015, and July 31, 2016, 850 women were screened and 677 women with class III obesity were enrolled. Of these, 441 underwent cesarean delivery and were subsequently randomized (219 to standard dressing and 222 to incisional negative pressure wound therapy). The primary outcome, overall composite wound morbidity rate, was 18%. This was not different between the two cohorts (incisional negative pressure wound therapy 17% vs standard dressing 19%, relative risk 0.9 [95% CI 0.5-1.4]).
   CONCLUSION: Prophylactic incisional negative pressure wound therapy use did not reduce postoperative wound morbidity when compared with a standard surgical dressing in women with class III obesity.
C1 [Hussamy, Deana J.; Wortman, Alison C.; McIntire, Donald D.; Leveno, Kenneth J.; Casey, Brian M.; Roberts, Scott W.] Univ Texas Southwestern Med Ctr Dallas, Dept Obstet & Gynecol, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center
RP Roberts, SW (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Obstet & Gynecol, Dallas, TX 75390 USA.
EM Scott.Roberts@UTSouthwestern.edu
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   Yu LL, 2018, AM J OBSTET GYNECOL, V218, P200, DOI 10.1016/j.ajog.2017.09.017
NR 28
TC 28
Z9 29
U1 3
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD OCT
PY 2019
VL 134
IS 4
BP 781
EP 789
DI 10.1097/AOG.0000000000003465
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Obstetrics & Gynecology
GA KK5NM
UT WOS:000512788400023
PM 31503147
DA 2026-07-24
ER
PT J
AU Ridwan, S
   Grote, A
   Simon, M
AF Ridwan, Sami
   Grote, Alexander
   Simon, Matthias
TI Safety and Efficacy of Negative Pressure Wound Therapy for Deep Spinal
   Wound Infections After Dural Exposure, Durotomy, or Intradural Surgery
SO WORLD NEUROSURGERY
LA English
DT Article
DE Dura; NPWT; Revision surgery; Spinal surgery; Spinal infection; Spine;
   VAC
ID VACUUM-ASSISTED-CLOSURE; CEREBELLAR HEMORRHAGE; POSTOPERATIVE
   INFECTIONS; LUMBAR SPINE; RISK-FACTORS; MANAGEMENT; FUSION;
   INSTRUMENTATION; COMPLICATIONS; IRRIGATION
AB BACKGROUND: Negative pressure wound therapy (NPWT) for deep spinal wound infections after exposure or opening of the dura can carry significant risks (i.e., cerebrospinal fluid infections and fistulas). In the present study, we reviewed a fairly large and recent experience with such patients.
   METHODS: We identified 25 patients with exposure and/or incision of the dura who had undergone NPWT from January 2014 to June 2018 for deep spinal wound infections. The demographic data, specifics of primary surgery and NPWT (i.e., dressing changes, duration, time required for wound healing), patients' clinical course, outcomes, and microbiological findings were studied. Application of a Granufoam vacuum dressing with a continuous negative pressure of 60 mm Hg was performed after proper debridement.
   RESULTS: Of the 25 patients, 13 were women and 12 were men (median age, 69 years). They had primarily undergone treatment for spinal tumors (n = 7), infections and degenerative disease (n = 8 each), or fractures (n = 2), with instrumentation in 18 patients (72%). The dura was exposed in all 25 patients and had been incised in 10 (40%) patients (intended incision, 3; accidental incision, 7). Most patients had been treated for a lumbar wound infection (64%). A microorganism was detected in 84% of the cases, with Staphylococcus aureus accounting for most of the infections (48%). NPWT was concluded after a median of 4 dressing changes (range, 2-14) and 19 days (range, 10-70), with no implant removal required in any patient. NPWT application was observed to be safe without cerebrospinal fluid-related complications. The presence of comorbidities (28% had diabetes) had no effect on the treatment results.
   CONCLUSIONS: NPWT can be safely applied for deep spinal wound infections after dura exposure or durotomy during previous spine surgery.
C1 [Ridwan, Sami; Grote, Alexander; Simon, Matthias] Bethel Clin, Dept Neurosurg, Bielefeld, Germany.
RP Ridwan, S (通讯作者)，Bethel Clin, Dept Neurosurg, Bielefeld, Germany.
EM sami.ridwan@yahoo.de
RI Ridwan, Sami/U-9749-2019; Grote, Alexander/HLP-5518-2023
OI Ridwan, Sami/0000-0001-5103-9560; Grote, Alexander/0000-0002-6545-0622
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NR 43
TC 13
Z9 18
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD FEB
PY 2020
VL 134
BP E624
EP E630
DI 10.1016/j.wneu.2019.10.146
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA KK6VS
UT WOS:000512878200076
PM 31678318
DA 2026-07-24
ER
PT J
AU Tsang, CLN
   Gunanayagam, P
   Feitosa, R
   Villalba, L
AF Tsang, Chi Lap Nicholas
   Gunanayagam, Prashanth
   Feitosa, Rui
   Villalba, Laurencia
TI High Output Chylous Fistula Post First Rib Resection
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID LYMPH-NODE DISSECTION; THORACIC-DUCT; MANAGEMENT; LEAK
AB We present a patient who developed high output chyle leak post left first-rib resection for neurogenic thoracic outlet syndrome. The persistent high output chylorrhea was refractory to 3 surgical reexplorations attempting to ligate leaking branches, bed rest, nonfat diet, parenteral nutrition, octreotide administration, and vacuum-assisted closure (VAC) therapy. In addition, she developed hypovolemia, hyponatremia, and hypoalbuminemia. Control of the chylous fistula was achieved by reattaching the sternocleidomastoid muscle laterally to protect the phrenic nerve and brachial plexus in order to redirect chyle to the medial portion of the neck incision site. This was supported by the application of fibrin sealants in combination with VAC therapy. The patient was discharged after a 27-day hospital stay with complete resolution of her chylous fistula prior to discharge.
C1 [Tsang, Chi Lap Nicholas; Gunanayagam, Prashanth; Feitosa, Rui; Villalba, Laurencia] Wollongong Hosp, Dept Surg, Wollongong, NSW, Australia.
   [Tsang, Chi Lap Nicholas; Villalba, Laurencia] Univ Wollongong, Grad Sch Med, Wollongong, NSW, Australia.
C3 Wollongong Hospital; University of Wollongong
RP Tsang, CLN (通讯作者)，Wollongong Hosp, Dept Surg, Wollongong, NSW, Australia.
EM ncltsang@gmail.com
OI Tsang, Chi Lap Nicholas/0000-0002-7503-469X; Villalba,
   Laurencia/0000-0002-3143-6785
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NR 25
TC 2
Z9 2
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD FEB
PY 2020
VL 63
AR 455.e1
DI 10.1016/j.avsg.2019.07.023
PG 5
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA KK7PY
UT WOS:000512931700052
PM 31622760
DA 2026-07-24
ER
PT J
AU Bilgin, IA
   Bas, M
   Demir, S
   Esen, E
   Kirbiyik, E
   Aghayeva, A
   Ozben, V
   Aytac, E
   Baca, B
   Hamzaoglu, I
   Karahasanoglu, T
AF Bilgin, Ismail Ahmet
   Bas, Mustafa
   Demir, Sehri
   Esen, Eren
   Kirbiyik, Ebru
   Aghayeva, Afag
   Ozben, Volkan
   Aytac, Erman
   Baca, Bilgi
   Hamzaoglu, Ismail
   Karahasanoglu, Tayfun
TI Management of Complicated Ostomy Dehiscence A Case Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Autolytic debridement; Complex colorectal surgery; Negative pressure
   wound therapy; Ostomy; Silver dressings; Stoma; Wound dehiscence; Wound
   management
ID QUALITY-OF-LIFE
AB BACKGROUND:
   Stoma creation is a common procedure in colorectal surgery. Despite improved surgical techniques, ostomy-related wound complications may prolong the recovery period and impair health-related quality of life. Negative pressure wound therapy (NPWT), autolytic debridement agents, and silver dressings are often used for managing complex wound infection and dehiscence. These applications have the potential to increase patient comfort and accelerate recovery.
   CASE:
   We report our experience in a 66 year old female who had a wound dehiscence involving the ostomy after robotic abdominoperineal resection. Her medical history was significant for a rectovaginal fistula which occurred after a low anterior resection for rectal cancer 5 years ago. Interventions for treatment of the dehiscence were use of NPWT, autolytic debriding agent, and silver dressing.
   CONCLUSION:
   Combined use of these interventions for dehiscence of an ostomy can minimize patient discomfort and accelerate wound healing.
C1 [Bilgin, Ismail Ahmet; Bas, Mustafa; Demir, Sehri; Esen, Eren; Kirbiyik, Ebru; Aghayeva, Afag; Ozben, Volkan; Aytac, Erman; Baca, Bilgi; Hamzaoglu, Ismail; Karahasanoglu, Tayfun] Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Gen Surg, Darussafaka Mahallesi,Buyukdere Cd 40, TR-34457 Istanbul, Turkey.
   [Bas, Mustafa] Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Istanbul, Turkey.
C3 Acibadem University; Istanbul University - Cerrahpasa
RP Bilgin, IA (通讯作者)，Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Gen Surg, Darussafaka Mahallesi,Buyukdere Cd 40, TR-34457 Istanbul, Turkey.
EM isahbilgin@hotmail.com
RI ; hamzaoglu, ismail/F-5400-2016; Aytac, Erman/HLW-2224-2023; Esen,
   Eren/AAF-3624-2021
OI Baş, Mustafa/0009-0004-3622-1187; 
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   Maydick-Youngberg D, 2017, OSTOMY WOUND MANAG, V63, P10
   Nichols TR, 2016, J WOUND OSTOMY CONT, V43, P616, DOI 10.1097/WON.0000000000000279
   Nichols T, 2018, J WOUND OSTOMY CONT, V45, P438, DOI 10.1097/WON.0000000000000457
   Powers JG, 2016, J AM ACAD DERMATOL, V74, P607, DOI 10.1016/j.jaad.2015.08.070
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   Simoes D, 2018, EUR J PHARM BIOPHARM, V127, P130, DOI 10.1016/j.ejpb.2018.02.022
NR 16
TC 1
Z9 3
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JAN-FEB
PY 2020
VL 47
IS 1
BP 72
EP 74
DI 10.1097/WON.0000000000000611
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA KL0VK
UT WOS:000513150500011
PM 31929448
DA 2026-07-24
ER
PT J
AU Baysal, Ö
   Saglam, F
   Akgülle, AH
   Sofulu, Ö
   Yigit, O
   Sirin, E
   Erol, B
AF Baysal, Ozgur
   Saglam, Fevzi
   Akgulle, Ahmet Hamdi
   Sofulu, Omer
   Yigit, Okan
   Sirin, Evrim
   Erol, Bulent
TI Factors affecting postmusculoskeletal tumour surgery wound problem
   treatment with negative pressure wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE musculoskeletal tumour surgery; negative pressure wound therapy; wound
   complication
ID SOFT-TISSUE SARCOMA; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   COMPLICATIONS; EXTREMITY; INFECTION; RESECTION
AB The aim of the study is to investigate the risk factors identified in literature that have been associated with prolonged Negative Pressure Wound Therapy (NPWT). Our study included patients who developed local wound problems after bone or soft tissue sarcoma surgery with negative margin at our clinic between 2012 and 2018 and treated with NPWT. All patients were followed up of at least 6 months. Sex, albumin level, skin infiltration, type of wound problem, postoperative intensive care unit (ICU) requirement, and intraoperative blood loss were found to be influential factors on NPWT > 10 sessions. We conclude that treatment may be prolonged and the necessary precautions need to be taken in patients with an impaired preoperative nutritional condition, with intraoperative high amount of blood loss, and with long postoperative stays in the ICU as well as if the underlying cause for wound problem is an infection.
C1 [Baysal, Ozgur; Saglam, Fevzi; Akgulle, Ahmet Hamdi; Sofulu, Omer; Yigit, Okan; Sirin, Evrim; Erol, Bulent] Marmara Univ, Dept Orthopaed & Traumatol, Pendik Training & Res Hosp, Istanbul, Turkey.
C3 Marmara University
RP Baysal, Ö (通讯作者)，Fevzicakmak Mah Muhsin Yazicioglu Cad 10, Istanbul, Turkey.
EM drozgurbaysal@gmail.com
RI /AAG-2397-2021; SAGLAM, FEVZİ/AAN-9403-2020; SOFULU, OMER/AGZ-9118-2022;
   Erol, Bulent/AAG-2982-2021; YİĞİT, OKAN/LXV-4148-2024; Baysal,
   Özgür/AAR-6106-2021
OI Akgülle, Ahmet Hamdi/0000-0002-1216-9589; SOFULU,
   OMER/0000-0002-5210-224X; Erol, Bulent/0000-0001-7099-6374; YİĞİT,
   OKAN/0000-0001-9708-5351; Baysal, Özgür/0000-0001-5150-8857
CR [Anonymous], 2004, HOSP EPIDEMIOL INFEC
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NR 28
TC 3
Z9 3
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2020
VL 17
IS 3
BP 692
EP 700
DI 10.1111/iwj.13326
EA FEB 2020
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LH4PB
UT WOS:000513726300001
PM 32065733
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Lo Torto, F
   Turriziani, G
   Donato, C
   Marcasciano, M
   Redi, U
   Greco, M
   Miraldi, F
   Ribuffo, D
AF Lo Torto, Federico
   Turriziani, Gianmarco
   Donato, Casella
   Marcasciano, Marco
   Redi, Ugo
   Greco, Manfredi
   Miraldi, Fabio
   Ribuffo, Diego
TI Deep sternal wound infection following cardiac surgery: A comparison of
   the monolateral with the bilateral pectoralis major flaps
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure therapy; pectoralis major muscle flap; sternal wound
   infection
ID VACUUM-ASSISTED CLOSURE; RECTUS-ABDOMINIS MUSCLE; SURGICAL SITE
   INFECTION; LONG-TERM SURVIVAL; OPEN-HEART-SURGERY; MEDIAN STERNOTOMY;
   RISK-FACTORS; POSTOPERATIVE MEDIASTINITIS; RECONSTRUCTION; MANAGEMENT
AB Deep sternal wound infections are a serious complication following sternotomy for cardiothoracic surgery. "Conventional" treatment provides debridement and secondary closure or closed catheter irrigation. The combination of the Negative Pressure Therapy with flap coverages is an accepted technique and one or both Pectoralis Major muscles could be chosen. A multistep protocol was adopted. One hundred and sixty seven patients were treated with the combination of Negative Pressure Therapy with the Pectoralis Major muscle flap: 86 monolateral flap and 81 bilateral flap reconstruction. The main complications (hematoma, seroma, dehiscence, and re-infection), the need for re-intervention, mortality rates, Intensive Care Unit, and hospitalisation time were assessed. The mono-pectoralis group had fewer complications and need for revision, with a shorter hospital stay. A statistically significant difference emerged for the hematoma rate (P = .0079). Monolateral flap should to be preferred because with the same coverage effectiveness, it guarantees the saving of controlateral muscle with its functionality and the possibility of its use in case of failure. Furthermore, as the technique is less invasive, it can be reserved for more fragile patients.
C1 [Lo Torto, Federico; Turriziani, Gianmarco; Marcasciano, Marco; Redi, Ugo; Ribuffo, Diego] Sapienza Univ Roma, Dept Plast Reconstruct & Aesthet Surg, Rome, Italy.
   [Donato, Casella] Azienda Osped Univ Senese, Dept Breast Canc Surg, Siena, Italy.
   [Greco, Manfredi] Magna Graecia Univ Catanzaro, Catanzaro, Italy.
   [Miraldi, Fabio] Sapienza Univ Roma, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Rome, Italy.
C3 Sapienza University Rome; University of Siena; University Hospital of
   Siena; Magna Graecia University of Catanzaro; Sapienza University Rome
RP Turriziani, G (通讯作者)，Via Piede la Valle 13, I-03030 Broccostella, Italy.
EM gianmarco.turriziani@gmail.com
RI GRECO, Manfredi/HZJ-5764-2023; turriziani, gianmarco/HKN-2908-2023;
   RIBUFFO, Diego/HLG-3305-2023; Torto, Federico/AAY-1852-2021;
   Marcasciano, Marco/HZJ-0259-2023
OI GRECO, Manfredi/0000-0001-6886-0160; turriziani,
   gianmarco/0000-0003-3172-5568; RIBUFFO, Diego/0000-0002-1844-7850;
   Casella, Donato/0000-0003-3946-2029
FU KCI Concepts, Inc
FX No contributions, technical help, financial and material support were
   provided by "V.A.C. ATS Therapy System, KCI Concepts, Inc, San Antonio,
   TX" or by others.
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NR 82
TC 18
Z9 21
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2020
VL 17
IS 3
BP 683
EP 691
DI 10.1111/iwj.13324
EA FEB 2020
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LH4PB
UT WOS:000513737600001
PM 32065728
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Mujahid, AM
   Khalid, FA
   Ali, N
   Sajjad, Y
   Khan, H
   Tarar, MN
AF Mujahid, Abdul Malik
   Khalid, Farrukh Aslam
   Ali, Noor
   Sajjad, Yawar
   Khan, Husnain
   Tarar, Moazzam Nazeer
TI Vacuum-assisted Closure in Integration of Skin Graft Over Scalp Wounds:
   A Randomised Control Trial
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Split thickness graft; Vacuum-assisted closure; Seroma; Scalp soft
   tissue defect
ID NEGATIVE-PRESSURE; THERAPY
AB Objective: To compare outcome of split thickness graft with and without vacuum-assisted closure over the scalp soft tissue defects in terms of graft take and complications.
   Study Design: Randomised controlled trial.
   Place and Duration of Study: Department of Plastic Surgery, Jinnah Burns and Reconstructive Surgery Centre, Lahore, from June 2017 to June 2018.
   Methodology: Patients with scalp soft tissue defects were recruited for the study. Patients with history of poly trauma, hypertension and diabetes mellitus were excluded. Patients were randomly divided into two groups by balloting lottery method. In group A, simple dressing were done after split thickness skin graft; and into group B, VAC dressing was applied after split thickness skin graft. Outcome variables (graft take and complications rate at recipient site) were assessed clinically at 2 weeks and analysed by Chi-square test with p-value <= 0.05 was taken as significant.
   Results: Mean age of 120 patients was 33.44 +/- 14.65 years. Graft take was seen in 24 (40.0%) patients in group A and in 56 (93.3%) patients in group B (p = 0.0001). Seroma was recorded in eight (13.3%) in group A (simple dressing) patients and one patient (1.67%) in group B (VAC dressing, p = 0.015), hematoma was seen in 04 (6.67%) versus 0 (0.0%), respectively (p = 0.042) and graft edge dehiscence in 03 (5.0%) versus 0 (0.0%), respectively (p = 0.079).
   Conclusion: Outcome of split skin graft over scalp soft tissue defects with VAC dressing is better than simple dressing in terms of graft take and complications rate.
C1 [Mujahid, Abdul Malik; Khalid, Farrukh Aslam; Ali, Noor; Sajjad, Yawar; Khan, Husnain; Tarar, Moazzam Nazeer] Allama Iqbal Med Coll Lahore, Dept Plast Surg, Jinnah Burn & Reconstruct Surg Ctr, Lahore, Pakistan.
RP Mujahid, AM (通讯作者)，Jinnah Burn & Reconstruct Surg Ctr, Lahore, Pakistan.
EM Iqbalian_127@yahoo.com
RI Khalid, Farrukh Aslam/AGZ-2968-2022
OI Khalid, Farrukh Aslam/0000-0001-9954-8890
CR [Anonymous], 2017, J WOUND MANAGEMENT R, DOI DOI 10.22467/
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 19
TC 5
Z9 7
U1 0
U2 7
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD FEB
PY 2020
VL 30
IS 2
BP 163
EP 167
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KM0NJ
UT WOS:000513813700011
PM 32036824
OA gold
DA 2026-07-24
ER
PT J
AU Burtt, KE
   Badash, I
   Leland, HA
   Gould, DJ
   Rounds, AD
   Patel, KM
   Carey, JN
AF Burtt, Karen E.
   Badash, Ido
   Leland, Hyuma A.
   Gould, Daniel J.
   Rounds, Alexis D.
   Patel, Ketan M.
   Carey, Joseph N.
TI The Efficacy of Negative Pressure Wound Therapy and Antibiotic Beads in
   Lower Extremity Salvage
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Negative-pressure wound therapy; Infection; Limb salvage; Microsurgery;
   Surgical flaps
ID VACUUM-ASSISTED CLOSURE; SEVERE OPEN FRACTURES; INFECTION-RATE;
   RISK-FACTORS; LOWER-LIMB; COMPLICATIONS; RECONSTRUCTION; MANAGEMENT;
   TRAUMA; TIME
AB Background: Antibiotic beads and negative pressure wound therapy (NPWT) represent two methods of wound management used during staged debridement in the post-trauma limb salvage pathway. The efficacy of NPWT and antibiotic beads in preventing infection remains unclear.
   Methods: This study is a retrospective review of patients with traumatic lower extremity open fractures who received NPWT and/or antibiotic beads before soft tissue reconstruction at an urban level 1 trauma center between August 2007 and December 2015. Patients with wound infections before application of NPWT and/or antibiotic beads were excluded.
   Results: In 73 lower extremities requiring soft tissue coverage, 46 received antibiotic beads and 48 received NPWT. Overall infection rate was 15.1%. Use of antibiotic beads was associated with a decreased risk of infection (6.4% versus 30.7%; P = 0.01). Use of NPWT was associated with an increased risk of one or more complications (45.7% versus 4.2%; P = 0.001). The development of infection was associated with a greater period of time between application of antibiotic beads (22 +/- 13 versus 12 +/- 6 d, P = 0.01) or NPWT (23 +/- 15 versus 10 +/- 11 d, P = 0.004) and soft tissue coverage. Overall limb salvage rate was 95.9%; secondary amputation was associated with development of infection (P = 0.001) but not with use of NPWT or antibiotic beads.
   Conclusions: Antibiotic beads may prevent infections in patients awaiting soft tissue coverage of wounds. NPWT may contribute to a greater rate of complication. Limb salvage was successful in most cases regardless of method of wound management. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Burtt, Karen E.] Mt Sinai Med Ctr, Dept Gen Surg, 4300 Alton Rd, Miami Beach, FL 33140 USA.
   [Badash, Ido; Gould, Daniel J.; Rounds, Alexis D.; Patel, Ketan M.; Carey, Joseph N.] USC, Keck Sch Med, Div Plast & Reconstruct Surg, Los Angeles, CA USA.
   [Leland, Hyuma A.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
C3 Mount Sinai Medical Center; University of Southern California;
   University of Southern California Keck Hospital; Harvard University;
   Harvard University Medical Affiliates; Beth Israel Deaconess Medical
   Center
RP Burtt, KE (通讯作者)，Mt Sinai Med Ctr, Dept Gen Surg, 4300 Alton Rd, Miami Beach, FL 33140 USA.
EM burtt@usc.edu
RI Badash, Ido/HLG-7360-2023
OI Badash, Ido/0000-0002-8512-1738; Rounds, Alexis/0000-0002-3927-3191
CR [Anonymous], INT SCH RES NOT
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NR 28
TC 7
Z9 11
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAR
PY 2020
VL 247
BP 499
EP 507
DI 10.1016/j.jss.2019.09.055
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KM1VD
UT WOS:000513908200065
PM 31690532
DA 2026-07-24
ER
PT J
AU Leong, S
   Lo, ZJ
AF Leong, SzeWai
   Lo, Zhiwen Joseph
TI Use of disposable negative pressure wound therapy on split-thickness
   skin graft recipient sites for peripheral arterial disease foot wounds:
   A case report
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE disposable negative pressure wound therapy; mechanically powered
   negative pressure wound device; SNAP therapy; split-thickness skin graft
AB Split-thickness skin graft (STSG) helps to promote healing of wounds by providing a viable soft tissue cover. However, the success of which is influenced by how well it takes to the recipient site. Studies have demonstrated that negative pressure wound therapy (NPWT) is an excellent modality to promote graft survival. Technological advancements have made possible the invention of disposable, ultraportable, and mechanically operated versions for improved user experience. Alas, little has been discussed about their benefits on STSG. Therefore, the purpose of this case report is to highlight the effective use of disposable NPWT on freshly applied STSG. We report here a novel use of the disposable NPWT (SNAP therapy system) for STSG recipient sites in two patients with peripheral arterial disease (PAD) foot wounds. In both patients, there was 100% STSG uptake, and the lightweight disposable NPWT system makes for a more cost-effective and comfortable experience for patients. Disposable NPWT may be a feasible alternative to conventional NPWT to aid with STSG uptake for PAD foot wound recipient sites.
C1 [Leong, SzeWai; Lo, Zhiwen Joseph] Tan Tock Seng Hosp, Gen Surg Dept, Vasc Surg Serv, Singapore, Singapore.
C3 Tan Tock Seng Hospital
RP Leong, S (通讯作者)，Block 5,Delta Ave 06-13, Singapore, Singapore.
EM szewai.leong@mohh.com.sg
CR Anderson JJ, 2012, DIABET FOOT ANKLE, V3, DOI 10.3402/dfa.v3i0.10204
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   Hudson DA, 2015, INT WOUND J, V12, P195, DOI 10.1111/iwj.12080
   Isaac AL, 2014, PRS-GLOB OPEN, V2, DOI 10.1097/GOX.0000000000000044
   Mohsin M, 2017, INDIAN J PLAST SURG, V50, P43, DOI 10.4103/ijps.IJPS_196_16
   Payne Caroline, 2014, Eplasty, V14, pe20
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   Tettelbach W, 2019, WOUNDS
   Thornton J.F., 2004, Selected readings in plastic surgery, V10, P1
NR 14
TC 5
Z9 7
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2020
VL 17
IS 3
BP 716
EP 721
DI 10.1111/iwj.13291
EA FEB 2020
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LH4PB
UT WOS:000514228900001
PM 32073214
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Summer, T
   Bota, O
   Armbruster, R
   Münchow, S
   Dragu, A
AF Summer, T.
   Bota, O.
   Armbruster, R.
   Muenchow, S.
   Dragu, A.
TI Soft tissue defects following tumor resection in the limbs and trunk
   Plastic reconstructive soft tissue and revision concepts
SO ORTHOPADE
LA German
DT Article
DE Plastic surgery; Reconstructive surgery; Microsurgery; Oncology;
   Vacuum-assisted closure
ID MICROSURGICAL RECONSTRUCTION; RESTORATION
AB Background Tissue defects of the trunk and limbs after oncologic surgery and radiation require plastic reconstructive tissue coverage. Depending on the location and size of the wound as well as the interdisciplinary treatment concept, different reconstructive procedures are performed. These range from skin transplantation to local and pedicle flaps, to perforator flaps and free microsurgical tissue transfer. Methods The modern "reconstructive ladder" can be regarded as an orientation for the sequence of the reconstructive options. Considering the patient's wishes and risk profile, an individual reconstructive concept must be devised. The best functional and simultaneously safest procedure with the smallest secondary defect is to be chosen. Wound preconditioning via vacuum-assisted closure can precede definitive tissue coverage in order to optimize local conditions. Conclusion Safe tissue coverage can be achieved even in advanced stages of oncologic disease and after extensive surgery by performing wound preconditioning and arteriovenous loop grafting to induce safe de novo recipient vessels for two-stage free tissue transfer. The choice between maximum plastic reconstructive options for a curative approach or limited palliative surgery is to be harmonized and balanced with therapeutic goals and the patient's biologic resources. Preservation and restoration of quality of life and functionality is the plastic surgeon's dictum.
C1 [Summer, T.; Bota, O.; Armbruster, R.; Muenchow, S.; Dragu, A.] Tech Univ Dresden, Univ Ctr Orthopadie & Unfallchirurg, Univ Klinikum Carl Gustav Carus, Abt Plast & Handchirurg, Fetscherstr 74, DE-01307 Dresden, Germany.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital
RP Summer, T (通讯作者)，Tech Univ Dresden, Univ Ctr Orthopadie & Unfallchirurg, Univ Klinikum Carl Gustav Carus, Abt Plast & Handchirurg, Fetscherstr 74, DE-01307 Dresden, Germany.
EM tobias.summer@uniklinikum-dresden.de
RI Dragu, Adrian/AAH-3506-2019; Bota, Olimpiu/AAN-4292-2021
OI Dragu, Adrian/0000-0003-4633-2695; Bota, Olimpiu/0000-0002-5836-1269
CR Baumann DP, 2010, PLAST RECONSTR SURG, V125, P1335, DOI 10.1097/PRS.0b013e3181d4fb4a
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NR 30
TC 4
Z9 4
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0085-4530
EI 1433-0431
J9 ORTHOPADE
JI Orthopade
PD FEB
PY 2020
VL 49
IS 2
SI SI
BP 169
EP 176
DI 10.1007/s00132-020-03871-2
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA KN0MX
UT WOS:000514534300011
PM 31974632
DA 2026-07-24
ER
PT J
AU Kim, S
   Kang, SI
AF Kim, Sohyun
   Kang, Sung Il
TI The effectiveness of negative-pressure wound therapy for wound healing
   after stoma reversal: a randomised control study (SR-PICO study)
SO TRIALS
LA English
DT Article
DE Negative-pressure wound therapy; PICO (TM) system; Purse-string suture;
   Stoma reversal
ID SURGICAL SITE INFECTION; LOOP ILEOSTOMY REVERSAL; PURSESTRING CLOSURE;
   TRIAL; RISK; METAANALYSIS; PREVENTION; PATIENT; REDUCE; SKIN
AB Background Although the wound-healing period for purse-string closure (PSC) after stoma reversal is longer than that required for the primary closure method, the rate of wound infection is reduced. The application of negative-pressure wound therapy (NPWT) can reduce the healing period for many types of wounds. Herein, we describe a planned trial to test the hypothesis that NPWT can reduce the healing period for PSC after stoma reversal. Methods/design Patients undergoing stoma reversal will be recruited and allocated into intervention and control groups, with 1:1 randomisation. Patients in the control group will receive standard postsurgical wound care; patients in the intervention group will receive NPWT using the PICO (TM) system. The target sample size will be 38 patients, as this will provide 80% power at the 5% level of significance to detect a 7-day reduction in the wound-healing period in the intervention group compared to that in the control group. The primary endpoint will be the duration to wound healing, defined as the time to nearly complete epithelisation of the wound, without any discharge or surgical site infection (SSI). Secondary endpoints will be the SSI rate, length of postoperative hospital stay, number of wound dressings and visits to the hospital for wound dressing after discharge, total cost of wound dressings, and patient and observer scar assessment scale scores. Discussion The results of this planned randomised controlled study will clarify the role of NPWT in patients undergoing stoma reversal and strengthen the rationale for choosing a dressing technique.
C1 [Kim, Sohyun; Kang, Sung Il] Yeungnam Univ, Dept Surg, Med Ctr, Coll Med, 170 Hyeonchung Ro, Daegu 42415, South Korea.
C3 Yeungnam University
RP Kang, SI (通讯作者)，Yeungnam Univ, Dept Surg, Med Ctr, Coll Med, 170 Hyeonchung Ro, Daegu 42415, South Korea.
EM sungiry@naver.com
OI Kang, Sung Il/0000-0002-4751-5779
FU 2019 Yeungnam University Research Grant programme [2019A580017]
FX This work was supported with non-profit grants from the 2019 Yeungnam
   University Research Grant programme (2019A580017). The funder had no
   role in the study design. The funder also will have no role in data
   collection, analysis, interpretation, or presentation of the results.
   The authors declare that there was neither any support from, nor a
   relationship with, the company manufacturing the dressing material
   device in this study.
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NR 18
TC 14
Z9 16
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JAN 6
PY 2020
VL 21
IS 1
AR 24
DI 10.1186/s13063-019-3925-z
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KN2BY
UT WOS:000514647500006
PM 31907033
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Benrashid, E
   Youngwirth, LM
   Guest, K
   Cox, MW
   Shortell, CK
   Dillavou, ED
AF Benrashid, Ehsan
   Youngwirth, Linda M.
   Guest, Kimberly
   Cox, Mitchell W.
   Shortell, Cynthia K.
   Dillavou, Ellen D.
TI Negative pressure wound therapy reduces surgical site infections
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 32nd Annual Meeting of the Eastern-Vascular-Society (EVS)
CY SEP 06-08, 2018
CL Washington, DC
SP Eastern Vasc Soc
DE Surgical site infection; Wound closure; Perioperative care
ID VASCULAR-SURGERY; RISK-FACTORS; ARTERIAL RECONSTRUCTION; COLORECTAL
   SURGERY; PREDICTORS; PREVENTION; OUTCOMES; REVASCULARIZATION;
   COMPLICATIONS; REDUCTION
AB Objective: Surgical site infection (SSI) with lower extremity incisions represents a modifiable source of major morbidity. Our institutional bundled care protocol to decrease SSI includes optimization of perioperative risk factors, dedicated wound closure tray, and voluntary use of a closed surface negative pressure wound therapy (cNPWT) device applied over closed incisions in the operating room. This study examined the individual effect of cNPWT on SSI reduction and other perioperative outcomes.
   Methods: All patients with lower extremity or infrainguinal incisions between January 2016 and December 2017 were prospectively identified and tracked for infectious complications. All patients were treated with the same perioperative care bundle to reduce SSI. cNPWT was applied over closed incisions at the discretion of the surgeon. The 90-day outcomes regarding SSI, return to operating room, death, and readmission were tracked. Univariate and multivariate analysis using binary logistic regression for factors associated with SSI was performed for patients with and without cNPWT devices, with P < .05 determined to be significant.
   Results: There were 504 patients included, 225 with cNPWT and 279 with standard dressings. Between the groups, there were no major differences in mean age, mean body mass index, perioperative transfusions, use of prosthetic, reoperative field, dialysis status, and presence of diabetes. There were significantly more women (39.6% vs 27.2% female; P < .01) and active smokers (47.1% vs 30.2%; P < .01) in the cNPWT group along with increased mean operative times (238.3 vs 189.0 minutes; P < .01). Univariate analysis revealed significantly fewer SSIs with cNPWT (9.8% vs 19.0% in standard dressings; P < .01) along with decreased perioperative mortality (5.8% vs 11.2%; P = .04). There were no differences in return to operating room (27.6% cNPWT vs 27.7% standard; P = .97) or readmissions (29.8% cNPWT vs 26.5%; P = .43), but more returns to the operating room were for wound-related problems in the standard dressings group (48.3% vs 26.2%; P < .01). Binary logistic regression using an SSI end point demonstrated that female sex increases SSI (odds ratio, 2.43; confidence interval, 1.37-4.30; P < .01), whereas cNPWT reduces SSI (odds ratio, 0.32; confidence interval, 0.17-0.63; P < .01).
   Conclusions: The use of negative pressure wound therapy devices decreases the incidence of infrainguinal wound infections. This occurs as an independent factor as part of a patient care bundle targeting modifiable variables in perioperative care.
C1 [Benrashid, Ehsan; Youngwirth, Linda M.; Guest, Kimberly; Cox, Mitchell W.; Shortell, Cynthia K.; Dillavou, Ellen D.] Duke Univ, Med Ctr, Dept Surg, Div Vasc Surg, Durham, NC 27710 USA.
C3 Duke University
RP Dillavou, ED (通讯作者)，Div Vasc Surg, Vasc Surg, 407 Crutchfield St, Durham, NC 27704 USA.
EM ellen.dillavou@duke.edu
RI Cox, Mitchell/AHD-6296-2022
OI Benrashid, Ehsan/0000-0003-4216-6095
FU Acelity Corp, San Antonio, TX, USA
FX This work was funded in part by Acelity Corp, San Antonio, TX, USA.
   Acelity had no involvement in the study design; collection, analysis,
   and interpretation of data; manuscript writing; or decision to submit
   the manuscript for publication.
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NR 32
TC 21
Z9 22
U1 1
U2 12
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD MAR
PY 2020
VL 71
IS 3
BP 896
EP 904
DI 10.1016/j.jvs.2019.05.066
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA KN4ZJ
UT WOS:000514846800039
PM 31471232
DA 2026-07-24
ER
PT J
AU Älgå, A
   Haweizy, R
   Bashaireh, K
   Wong, S
   Lundgren, KC
   von Schreeb, J
   Malmstedt, J
AF Alga, Andreas
   Haweizy, Rawand
   Bashaireh, Khaldoon
   Wong, Sidney
   Lundgren, Kalle Conneryd
   von Schreeb, Johan
   Malmstedt, Jonas
TI Negative pressure wound therapy versus standard treatment in patients
   with acute conflict-related extremity wounds: a pragmatic, multisite,
   randomised controlled trial
SO LANCET GLOBAL HEALTH
LA English
DT Article
ID OPEN FRACTURE
AB Background In armed conflict, injuries among civilians are usually complex and commonly affect the extremities. Negative pressure wound therapy (NPWT) is an alternative to standard treatment of acute conflict-related extremity wounds. We aimed to compare the safety and effectiveness of NPWT with that of standard treatment.
   Methods In this pragmatic, randomised, controlled superiority trial done at two civilian hospitals in Jordan and Iraq, we recruited patients aged 18 years or older, presenting with a conflict-related extremity wound within 72 h after injury. Participants were assigned (1:1) to receive either NPWT or standard treatment. We used a predefined, computer-generated randomisation list with three block sizes. Participants and their treating physicians were not masked to treatment allocation. The primary endpoint was wound closure by day 5. The coprimary endpoint was net clinical benefit, defined as a composite of wound closure by day 5 and freedom from any bleeding, wound infection, sepsis, or amputation of the index limb. Analysis was by intention to treat. The trial is registered with ClinicalTrials. gov, number NCT02444598, and is closed to accrual.
   Findings Between June 9, 2015, and Oct 24, 2018, 174 patients were randomly assigned to either the NPWT group (n=88) or the standard treatment group (n=86). Five patients in the NPWT group and four in the standard treatment group were excluded from the intention-to-treat analysis. By day 5, 41 (49%) of 83 participants in the NPWT group and 49 (60%) of 82 participants in the standard treatment group had closed wounds, with an absolute difference of 10 percentage points (95% CI -5 to 25, p=0.212; risk ratio [RR] 0.83, 95% CI 0.62 to 1.09). Net clinical benefit was seen in 33 (41%) of 81 participants in the NPWT group and 34 (44%) of 78 participants in the standard treatment group, with an absolute difference of 3 percentage points (95% CI -12 to 18, p=0.750; RR 0.93, 95% CI 0.65 to 1.35). There was one in-hospital death in the standard treatment group and none in the NPWT group. The proportion of participants with sepsis, bleeding leading to blood transfusion, and limb amputation did not differ between groups.
   Interpretation NPWT did not yield superior clinical outcomes compared with standard treatment for acute conflict-related extremity wounds. The results of this study not only question the use of NPWT, but also question the tendency for new and costly treatments to be introduced into resource-limited conflict settings without supporting evidence for their effectiveness. This study shows that high-quality, randomised trials in challenging settings are possible, and our findings support the call for further research that will generate context-specific evidence. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.
C1 [Alga, Andreas; Malmstedt, Jonas] Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, SE-17177 Stockholm, Sweden.
   [Haweizy, Rawand] Hawler Med Univ, Coll Med, Erbil, Iraq.
   [Bashaireh, Khaldoon] Jordan Univ Sci & Technol, Dept Special Surg, Irbid, Jordan.
   [Wong, Sidney] Operat Ctr Amsterdam, Med Sans Frontieres, Amsterdam, Netherlands.
   [Lundgren, Kalle Conneryd] Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Alga, Andreas; von Schreeb, Johan] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
C3 Karolinska Institutet; Sodersjukhuset Hospital; Hawler Medical
   University; Jordan University of Science & Technology; Doctors Without
   Borders; Karolinska Institutet; Karolinska University Hospital;
   Karolinska Institutet
RP Älgå, A (通讯作者)，Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, SE-17177 Stockholm, Sweden.
EM andreas.alga@ki.se
RI Lundgren, Kalle/E-9056-2015; Älgå, Andreas/B-1070-2019
OI Älgå, Andreas/0000-0001-5245-7668; Bashaireh,
   Khaldoon/0000-0003-0580-2355; Malmstedt, Jonas/0000-0002-2758-9623
FU Stockholm County Council; Swedish National Board of Health and Welfare;
   Medecins Sans Frontieres
FX The Stockholm County Council, the Swedish National Board of Health and
   Welfare, and Medecins Sans Frontieres.
CR Aboutanos MB, 1997, J TRAUMA, V43, P719, DOI 10.1097/00005373-199710000-00031
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   WHO, 2019, SYR AR REP 1 STEPS R
NR 23
TC 24
Z9 30
U1 0
U2 8
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 2214-109X
J9 LANCET GLOB HEALTH
JI Lancet Glob. Health
PY 2020
VL 8
IS 3
BP E423
EP E429
DI 10.1016/S2214-109X(19)30547-9
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA KN5BJ
UT WOS:000514852000031
PM 32087175
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Guetta, O
   Brotfain, E
   Shaked, G
   Sebbag, G
   Klein, M
   Czeiger, D
AF Guetta, Ohad
   Brotfain, Evgeni
   Shaked, Gad
   Sebbag, Gilbert
   Klein, Moti
   Czeiger, David
TI Intra-abdominal pressure may be elevated in patients with open abdomen
   after emergent laparotomy
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Abdominal compartment syndrome (ACS); Abdominal wound closure
   techniques; Intra-abdominal pressure (IAP); Intra-abdominal hypertension
   (IAH); Surgical decompression; Lactic acid
ID ABDOMINAL COMPARTMENT SYNDROME; DAMAGE CONTROL; HYPERTENSION; CLOSURE
AB Purpose To estimate the change in intra-abdominal pressure (IAP) among critically ill patient who were left with open abdomen and temporary abdominal closure after laparotomy, during the first 48 h after admission. Methods A cohort study in a single ICU in a tertiary care hospital. All adult patients admitted to the ICU after emergent laparotomy for acute abdomen or trauma, who were left with temporary abdominal closure (TAC), were included. Patients were followed up to 48 h. IAP was routinely measured at 0, 6, 12, 24, and 48 h after admission to ICU. Results Thirty-nine patients were included, 34 were operated due to acute abdomen and 5 due to abdominal trauma. Seventeen patients were treated with skin closure, 13 with Bogota bag, and 9 with negative pressure wound therapy (NPWT). Eleven patients (28.2%) had IAP of 15 mmHg or above at time 0, (mean pressure 19.0 +/- 3.0 mmHg), and it dropped to 12 +/- 4 mmHg within 48 h (p < 0.01). Reduction in lactate level (2.4 +/- 1.0 to 1.2 +/- 0.2 mmol/L, p < 0.01) and increase in PaO2/FiO(2) ratio (163 +/- 34 to 231 +/- 83, p = 0.03) were observed as well after 48 h. Conclusions This is the first large report of IAP in open abdomen. Elevated IAP may be measured in open abdomen and may subsequently relieve after 48 h.
C1 [Guetta, Ohad; Sebbag, Gilbert; Czeiger, David] Soroka Univ Med Ctr, Ben Gurion Univ Negev, Dept Gen Surg B, Beer Sheva, Israel.
   [Brotfain, Evgeni] Soroka Univ Med Ctr, Ben Gurion Univ Negev, Dept Anesthesiol, Crit Care, Beer Sheva, Israel.
   [Shaked, Gad] Soroka Univ Med Ctr, Ben Gurion Univ Negev, Head Trauma Unit, Beer Sheva, Israel.
   [Klein, Moti] Ben Gurion Univ Negev, Soroka Med Ctr, Head Crit Care Dept, Gen Intens Care Unit, Beer Sheva, Israel.
C3 Ben-Gurion University of the Negev; Soroka Medical Center; Ben-Gurion
   University of the Negev; Soroka Medical Center; Ben-Gurion University of
   the Negev; Soroka Medical Center; Ben-Gurion University of the Negev;
   Soroka Medical Center
RP Guetta, O (通讯作者)，Soroka Univ Med Ctr, Ben Gurion Univ Negev, Dept Gen Surg B, Beer Sheva, Israel.
EM ohadguetta@gmail.com
RI klein, moti/AAR-6552-2021
CR Chiara O, 2016, J TRAUMA ACUTE CARE, V80, P173, DOI 10.1097/TA.0000000000000882
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
   De Waele JJ, 2006, CRIT CARE, V10, DOI 10.1186/cc4870
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   Iyer D, 2014, ACTA ANAESTH SCAND, V58, P1267, DOI 10.1111/aas.12409
   Kirkpatrick AW, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0183-4
   Kirkpatrick AW, 2013, INTENS CARE MED, V39, P1190, DOI 10.1007/s00134-013-2906-z
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NR 20
TC 2
Z9 6
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD FEB
PY 2020
VL 405
IS 1
BP 91
EP 96
DI 10.1007/s00423-020-01854-7
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KN9IX
UT WOS:000515162200010
PM 31955259
DA 2026-07-24
ER
PT J
AU Costa, ML
   Achten, J
   Knight, R
   Bruce, J
   Dutton, SJ
   Madan, J
   Dritsaki, M
   Parsons, N
   Fernandez, M
   Grant, R
   Nanchahal, J
AF Costa, Matthew L.
   Achten, Juul
   Knight, Ruth
   Bruce, Julie
   Dutton, Susan J.
   Madan, Jason
   Dritsaki, Melina
   Parsons, Nick
   Fernandez, Miguel
   Grant, Richard
   Nanchahal, Jagdeep
CA WHIST Trial Collaborators
TI Effect of Incisional Negative Pressure Wound Therapy vs Standard Wound
   Dressing on Deep Surgical Site Infection After Surgery for Lower Limb
   Fractures Associated With Major Trauma The WHIST Randomized Clinical
   Trial
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID MANAGEMENT; DISABILITY
AB Importance Following surgery to treat major trauma-related fractures, deep wound infection rates are high. It is not known if negative pressure wound therapy can reduce infection rates in this setting. Objective To assess outcomes in patients who have incisions resulting from surgery for lower limb fractures related to major trauma and were treated with either incisional negative pressure wound therapy or standard wound dressing. Design, Setting, and Participants A randomized clinical trial conducted at 24 trauma hospitals representing the UK Major Trauma Network that included 1548 patients aged 16 years or older who underwent surgery for a lower limb fracture caused by major trauma from July 7, 2016, through April 17, 2018, with follow-up to December 11, 2018. Interventions Incisional negative pressure wound therapy (n = 785), which involved a specialized dressing used to create negative pressure over the wound, vs standard wound dressing not involving negative pressure (n = 763). Main Outcomes and Measures The primary outcome measure was deep surgical site infection at 30 days diagnosed according to the criteria from the US Centers for Disease Control and Prevention. A preplanned secondary analysis of the primary outcome was performed at 90 days. The secondary outcomes were patient-reported disability (Disability Rating Index), health-related quality of life (EuroQol 5-level EQ-5D), surgical scar assessment (Patient and Observer Scar Assessment Scale), and chronic pain (Douleur Neuropathique Questionnaire) at 3 and 6 months, as well as other local wound healing complications at 30 days. Results Among 1548 participants who were randomized (mean [SD] age, 49.8 [20.3] years; 561 [36%] were aged <= 40 years; 583 [38%] women; and 881 [57%] had multiple injuries), 1519 (98%) had data available for the primary outcome. At 30 days, deep surgical site infection occurred in 5.84% (45 of 770 patients) of the incisional negative pressure wound therapy group and in 6.68% (50 of 749 patients) of the standard wound dressing group (odds ratio, 0.87 [95% CI, 0.57 to 1.33]; absolute risk difference, -0.77% [95% CI, -3.19% to 1.66%]; P = .52). There was no significant difference in the deep surgical site infection rate at 90 days (11.4% [72 of 629 patients] in the incisional negative pressure wound therapy group vs 13.2% [78 of 590 patients] in the standard wound dressing group; odds ratio, 0.84 [95% CI, 0.59 to 1.19]; absolute risk difference, -1.76% [95% CI, -5.41% to 1.90%]; P = .32). For the 5 prespecified secondary outcomes reported, there were no significant differences at any time point. Conclusions and Relevance Among patients who underwent surgery for major trauma-related lower limb fractures, use of incisional negative pressure wound therapy, compared with standard wound dressing, resulted in no significant difference in the rate of deep surgical site infection. The findings do not support the use of incisional negative pressure wound therapy in this setting, although the event rate at 30 days was lower than expected.
C1 [Costa, Matthew L.; Achten, Juul; Fernandez, Miguel; Nanchahal, Jagdeep] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
   [Knight, Ruth; Dutton, Susan J.; Dritsaki, Melina] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Clin Trials Res Unit, Oxford, England.
   [Bruce, Julie; Madan, Jason] Univ Warwick, Warwick Med Sch, Clin Trials Unit, Coventry, W Midlands, England.
   [Parsons, Nick] Univ Warwick, Warwick Med Sch, Stat & Epidemiol Unit, Coventry, W Midlands, England.
C3 University of Oxford; University of Oxford; University of Warwick;
   University of Warwick
RP Costa, ML (通讯作者)，Univ Oxford, Oxford OX3 9DU, England.
EM matthew.costa@ndorms.ox.ac.uk
RI ; Parsons, Nick/AAA-8713-2019; Bruce, Julie/G-7588-2014; Achten,
   Juul/KUD-8515-2024
OI Madan, Jason/0000-0003-4316-1480; Knight, Ruth/0000-0001-6810-2845; Si,
   Alex/0000-0003-0041-0395; Thangaraj, Rajkumar/0000-0002-2324-0133;
   Costa, Matthew/0000-0003-3644-1388; Nanchahal,
   Jagdeep/0000-0002-9579-9411; Dutton, Susan/0000-0003-4573-5257; Parsons,
   Nick/0000-0001-9975-888X; Bruce, Julie/0000-0002-8462-7999; Achten,
   Juul/0000-0002-8857-5743
FU UK National Institute for Health Research Health Technology Assessment
   Programme [HTA14/199/14]; National Institute for Health Research Oxford
   Biomedical Research Centre; Smith and Nephew; National Institute for
   Health Research [ACF-2012-08-004, 14/199/14] Funding Source:
   researchfish
FX This project was funded by grant HTA14/199/14 from the UK National
   Institute for Health Research Health Technology Assessment Programme and
   was supported by the National Institute for Health Research Oxford
   Biomedical Research Centre. Smith and Nephew provided incisional
   negative pressure wound therapy dressings (PICO single use negative
   pressure wound therapy system) to recruiting centers.
CR Achten J, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-022115
   [Anonymous], MAJ TRAUM ASS IN MAN
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NR 18
TC 103
Z9 126
U1 0
U2 23
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD FEB 11
PY 2020
VL 323
IS 6
BP 519
EP 526
DI 10.1001/jama.2020.0059
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KO5BC
UT WOS:000515563800016
PM 32044942
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Wang, ZH
   Liu, T
   Cheng, YH
   Xin, DJ
   Qu, WQ
   Jiang, YG
   Wang, D
AF Wang, Zhenhai
   Liu, Tong
   Cheng, Yiheng
   Xin, Dajiang
   Qu, Wenqing
   Jiang, Yugui
   Wang, Dan
TI Tibial Nail Combined with Vacuum Sealing Drainage for Gustilo Grade IIIB
   Open Tibial Fractures: A Patient Series
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE intramedullary nail; open fracture; postoperative complication; tibia;
   trauma
ID MANAGEMENT
AB Gustilo grade IIIB open tibial fractures are relatively difficult to treat. We investigated the treatment effects of tibial intramedullary nails combined with vacuum sealing drainage (VSD) for Gustilo grade IIIB open tibial fractures. From March 2015 to March 2017, 13 cases of Gustilo grade IIIB open tibial fractures were treated with Expert Tibial Nails combined with VSD. Causes of injury included falls from a height (n = 9, 69.2%) and road accidents (n = 4, 30.8%). The duration from time of injury to hospital intake was 7.3 hours (range 5 to 9.5), and the time between injury and operation was 6.7 days (range 3 to 11). Six months after the operation, overall patient general health was investigated via the American Orthopaedic Foot and Ankle Society (AOFAS) ankle score and the physical and mental health dimensions of the Short-Form Health Survey 36 (SF-36). Postoperative complications and infections also were recorded. The results indicated that the median AOFAS score was 93.7 (range 89 to 97), with all individuals having either excellent (90 to 100; n = 10, 76.9%) or good (80 to 89; n = 3, 23.1%) outcomes. The median physical SF-36 score was 83.1 (range 72.5 to 93.0), and the median mental SF-36 score was 80.6 (range 69.7 to 92.0). Moreover, there were no instances of tibial shortening, neurovascular injury, postoperative complications, implant failure, malunion, or serious infections. In conclusion, intramedullary tibial nail combined with VSD is a safe and effective method to treat type grade IIIB open tibial fractures. (C) 2019 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Wang, Zhenhai; Liu, Tong; Cheng, Yiheng; Xin, Dajiang; Qu, Wenqing; Jiang, Yugui; Wang, Dan] Yantaishan Hosp, Yantai, Peoples R China.
   [Wang, Zhenhai; Liu, Tong; Cheng, Yiheng; Xin, Dajiang; Qu, Wenqing; Jiang, Yugui; Wang, Dan] Yantai Sino French Friendship Hosp, Yantai, Peoples R China.
RP Wang, ZH (通讯作者)，Yantaishan Hosp, Dept Orthopaed & Traumatol, Yantai 264000, Peoples R China.
EM ytzhenhai@163.com
CR Akgun U, 2019, J FOOT ANKLE SURG, V58, P497, DOI 10.1053/j.jfas.2018.09.027
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   Ibrahim Talal, 2007, J Foot Ankle Surg, V46, P65, DOI 10.1053/j.jfas.2006.12.002
   Isik A, 2014, MED SCI MONITOR, V20, P1369, DOI 10.12659/MSM.890804
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   Kumar Pankaj, 2006, Acta Orthop Belg, V72, P332
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   Yildirim A, 2017, INDIAN J ORTHOP, V51, P312, DOI 10.4103/0019-5413.205686
NR 17
TC 3
Z9 8
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAR-APR
PY 2020
VL 59
IS 2
BP 409
EP 412
DI 10.1053/j.jfas.2019.08.016
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA KQ7HN
UT WOS:000517090300032
PM 32131012
DA 2026-07-24
ER
PT J
AU Shah, AP
   Kurian, R
   Leung, E
AF Shah, A. P.
   Kurian, R.
   Leung, E.
TI Negative pressure wound therapy in elective stoma reversal surgery:
   results of a UK district general hospital pilot
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE Surgical site infection; Negative pressure wound therapy; Stoma reversal
   surgery; Colorectal cancer surgery; Wound management; Infection
   prevention
ID SURGICAL SITE INFECTION
AB The role of negative pressure wound therapy in stoma reversal surgery remains unknown. To evaluate this, a retrospective, non-randomized, single-institution, pilot study was conducted. Surgeon preference determined type of wound closure and application of the single-brand negative wound pressure device. No patient in the intervention group suffered wound complications, but five of the thirty-six patients in the control group suffered surgical site infection-related complications. Primary closure and negative pressure wound therapy use decreases wound complications in stoma reversal surgery, thereby alleviating the wound-management burden in hospitals and in the community. This has cost-saving implications, but further studies are needed. (C) 2019 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
C1 [Shah, A. P.; Kurian, R.; Leung, E.] Cty Hosp, Dept Gen Surg, Stonebow Rd, Hereford HR1 2ER, England.
RP Shah, AP (通讯作者)，Cty Hosp, Dept Gen Surg, Stonebow Rd, Hereford HR1 2ER, England.
EM adarsh.shah3@nhs.net
OI Shah, Adarsh/0000-0002-7004-1751
CR Badia JM, 2017, J HOSP INFECT, V96, P1, DOI 10.1016/j.jhin.2017.03.004
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Gachabayov M, 2019, TECH COLOPROCTOL, V23, P207, DOI 10.1007/s10151-019-01952-9
   Hall C, 2019, J AM COLL SURGEONS, V228, P393, DOI 10.1016/j.jamcollsurg.2018.12.006
   Jenks PJ, 2014, J HOSP INFECT, V86, P24, DOI 10.1016/j.jhin.2013.09.012
   Jones SM, 2005, POSTGRAD MED J, V81, P353, DOI 10.1136/pgmj.2004.026351
   NICE. PICO, NEG PRESS WOUND DRES
   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
   Strugala V, 2017, SURG INFECT, V18, P810, DOI 10.1089/sur.2017.156
   Tanner J, 2009, J HOSP INFECT, V72, P243, DOI 10.1016/j.jhin.2009.03.021
NR 10
TC 2
Z9 2
U1 0
U2 1
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD MAR
PY 2020
VL 104
IS 3
BP 332
EP 335
DI 10.1016/j.jhin.2019.11.006
PG 4
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA KR7DA
UT WOS:000517774900017
PM 31738986
DA 2026-07-24
ER
PT J
AU Popivanov, GI
   Mutafchiyski, VM
   Cirocchi, R
   Chipeva, SD
   Vasilev, VV
   Kjossev, KT
   Tabakov, MS
AF Popivanov, G. I.
   Mutafchiyski, V. M.
   Cirocchi, R.
   Chipeva, S. D.
   Vasilev, V. V.
   Kjossev, K. Ts.
   Tabakov, M. S.
TI Endoluminal negative pressure therapy in colorectal anastomotic leaks
SO COLORECTAL DISEASE
LA English
DT Review
DE colorectal surgery; complications; colorectal anastomotic leak;
   endoluminal negative pressure therapy; endosponge treatment
ID VACUUM-ASSISTED CLOSURE; ENDO-SPONGE TREATMENT; EXPERIENCE; RESECTION;
   REVERSAL; ETVARD
AB Aim The aim of the present work was to perform an up-to-date review of the literature on endoluminal negative pressure therapy for colorectal anastomotic leak.
   Method An electronic search in PubMed and Google Scholar and a manual search without language restrictions were performed on 25 January 2019. Only original series reporting endoluminal negative pressure therapy in colorectal anastomotic leaks were included. The primary outcome was the success rate (complete closure of the abscess cavity). The secondary outcomes were the rates of complications and stoma closure.
   Results Nineteen series with a total of 295 cases were analysed. The median distance of the anastomosis from the anal verge and the size of the abscess were 5.65 cm (4.9-10) and 6.0 cm (5-8.1) respectively. In 84.5% (78%-91%) the stoma was created at the first intervention. Neoadjuvant therapy was performed in 48.6% (3%-60%). Median 7 sponges (2-34) were used with median negative pressure 150 mmHg (125-700) for a median of 31 days (14-127). The success rate was 85.4% (80%-91%) with ileostomy closure in 72.6%. Complications were observed in 19% (13%-25%): abscesses 11.5% and anastomotic stenosis 4.4%. Laparotomy was required in 15% of the complications. The stoma was the only significant predictor for the success of the therapy (0.007, SE 0.004, P = 0.040).
   Conclusions The initial experience looks promising with an 85% success rate, which precludes risky re-resections with redo anastomosis or Hartmann's procedure. Despite the good initial results, definitive conclusions cannot be drawn because of the small sample size and the lack of high-quality comparative studies.
C1 [Popivanov, G. I.; Mutafchiyski, V. M.; Vasilev, V. V.; Kjossev, K. Ts.] Mil Med Acad, Dept Surg, Sofia, Bulgaria.
   [Cirocchi, R.] Univ Perugia, Dept Surg & Surg Sci, Perugia, Italy.
   [Chipeva, S. D.] Univ Natl & World Econ, Dept Stat & Econometr, Sofia, Bulgaria.
   [Tabakov, M. S.] MHAT Sv Ivan Rilski, Clin Abdominal Surg, Sofia, Bulgaria.
C3 Military Medical Academy Sofia; University of Perugia; University of
   National & World Economics - Bulgaria
RP Popivanov, GI (通讯作者)，Mil Med Acad, Sv Georgi Sofiiski Str 3, Sofia 1606, Bulgaria.
EM gerasimpopivanov@rocketmail.com
RI Popivanov, Georgi/IVH-4670-2023; Kjossev, Kirien/KQV-3036-2024;
   Cirocchi, Roberto/I-1197-2014
OI Popivanov, Georgi/0000-0001-9618-3187; 
CR [Anonymous], J HEPATO GASTRO 0625
   [Anonymous], 2013, GE Port J Gastroenterol
   [Anonymous], 2014, Surg Sci
   [Anonymous], NEGATIVE PRESSURE WO
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   Borstlap WAA, 2018, SURG ENDOSC, V32, P315, DOI 10.1007/s00464-017-5679-6
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   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 41
TC 24
Z9 28
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD MAR
PY 2020
VL 22
IS 3
BP 243
EP 253
DI 10.1111/codi.14754
PG 11
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA KR9JZ
UT WOS:000517930700003
PM 31274227
DA 2026-07-24
ER
PT J
AU De Martino, A
   Del Re, F
   Falcetta, G
   Morganti, R
   Ravenni, G
   Bortolotti, U
AF De Martino, Andrea
   Del Re, Federico
   Falcetta, Giosue
   Morganti, Riccardo
   Ravenni, Giacomo
   Bortolotti, Uberto
TI Sternal Wound Complications: Results of Routine Use of Negative Pressure
   Wound Therapy
SO BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE Sternotom; Patient Discharge; Duration of Therapy; Sternum;
   Hospitalization, Infections; Postoperative Complications
ID VACUUM-ASSISTED CLOSURE; PRACTICE GUIDELINE SERIES; RISK-FACTORS;
   CARDIAC-SURGERY; INFECTIONS; MANAGEMENT; IMPACT; MEDIASTINITIS;
   SURVIVAL; SOCIETY
AB Introduction: Negative pressure wound therapy (NPWT) has significantly improved outcomes in individuals with superficial and deep sternal wound dehiscence (SWD). We report our experience with NPWT to evaluate factors influencing effectiveness, duration of treatment and postoperative hospital stay.
   Methods: We reviewed 92 patients with postoperative SWD following a median sternotomy. Patients were divided into 2 groups: those with a superficial SWD (Group 1; 72, 78%) and those with a deep SWD (Group 2; 20, 28%). Group 1 was further divided into 3 subgroups based on NPWT duration.
   Results: In both groups, none of the preoperative characteristics examined showed a significant association with longer NPWT duration. In Group 2, there was a trend for postoperative bleeding and neurological complications to be associated with longer treatment duration. In the entire series, staph infection resulted a weak predictor of NPWT duration. In each Group 1 subgroup and in Group 2, treatment days were compared with duration of hospitalization until discharge. Mean post-NPWT hospital stay was 6 days in subgroup 1, 12 days in subgroup 2 and 20 days in subgroup 3 (P<0.0001). At a median 3-year follow-up, there were 4 late deaths, none related to wound complications. No cases of SWD recurrence were observed.
   Conclusion: Our results confirm the effectiveness of NPWT in SWD management, while excessive treatment duration might have a negative impact on the length of hospital stay. Further studies are needed to define an optimal use of NPWT protocol.
C1 [De Martino, Andrea; Del Re, Federico; Falcetta, Giosue; Ravenni, Giacomo; Bortolotti, Uberto] Univ Hosp, Sect Cardiac Surg, Pisa, Italy.
   [Morganti, Riccardo] Univ Hosp, Sect Stat, Pisa, Italy.
   [De Martino, Andrea; Del Re, Federico; Falcetta, Giosue; Morganti, Riccardo; Ravenni, Giacomo; Bortolotti, Uberto] Univ Hosp, Pisa, Italy.
C3 University of Pisa; Azienda Ospedaliero Universitaria Pisana; University
   of Pisa; Azienda Ospedaliero Universitaria Pisana; University of Pisa;
   Azienda Ospedaliero Universitaria Pisana
RP De Martino, A (通讯作者)，Univ Pisa, Sez Autonoma Cardiochirurg Univ, Via Paradisa 2, I-56124 Pisa, Italy.
EM andrea.demartino@unipi.it
RI De Martino, Andrea/M-6415-2019
OI De Martino, Andrea/0000-0003-2889-4918
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NR 25
TC 9
Z9 11
U1 0
U2 2
PU SOC BRASIL CIRURGIA CARDIOVASC
PI SAO PAULO SP
PA RUA AFONSO CELSO, 1178, SAO PAULO SP, 04119-061, BRAZIL
SN 0102-7638
EI 1678-9741
J9 BRAZ J CARDIOVA SURG
JI Braz. J. Cardiovasc. Surg.
PY 2020
VL 35
IS 1
BP 50
EP 57
DI 10.21470/1678-9741-2019-0242
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA KS3MJ
UT WOS:000518215300011
PM 32270960
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Gombert, A
   Van Vuuren, TMAJ
   Barbati, ME
   Toonder, IM
   Van Laanen, JHH
   Wittens, C
   Houman, HJ
AF Gombert, Alexander
   Van Vuuren, Timme M. A. J.
   Barbati, Mohammad E.
   Toonder, Irwin M.
   Van Laanen, Jorinde H. H.
   Wittens, Cees
   Houman, Houman Jalaie
TI Closed incisional negative pressure therapy may reduce surgical site
   infection rate following endophlebectomy with complementary
   polytetrafluoroethylene arteriovenous fistula of the common femoral vein
SO JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
LA English
DT Article
DE cINPT; Prevena; Endophlebectomy; Polytetrafluoroethylene; Arteriovenous
   fistula; Surgical site infections; Deep venous recanalization
ID WOUND COMPLICATIONS; EDITORS CHOICE; DISEASE; RECANALIZATION;
   ENDOVENECTOMY; PREVENTION; MANAGEMENT
AB Objective: Surgical desobliteration or endophlebectomy of the common femoral vein during deep venous recanalization with complementary polytetrafluoroethylene (PTFE) arteriovenous fistula (AVF), may lead to higher rates of surgical site infection (SSI). It has been reported that closed incisional negative pressure wound therapy (cINPT) may decrease SSI rates after different surgical procedures. The aim of this study was to determine the potential effect of cINPT on the SSI rate of femoral endophlebectomy with a complimentary PTFE AVF.
   Methods: Patients with recanalization of the femoral-iliac veins and femoral endophlebectomy with a complementary PTFE AVF and postoperative cINPT were identified. SSI, patency, and complication rates were analyzed.
   Results: This study included 65 patients with a mean age of 41 +/- 14 years. The mean procedure time was 240 +/- 11.9 minutes. Primary patency rate was 69.2% and secondary patency rate was 78.4%. SSI classified as Szilagyi I, II, and III occurred in 7.6% (n = 5), 3% (n = 2), and 7.6% (n = 5), respectively, with an overall SSI rate of 18.2%. Surgical wound revision with the application of a vacuum pump was required in 10.7% (n = 7). A multivariate analysis showed that the duration of the surgical procedure (P =.003) as well as lymphatic fistulas (P =.044) to have a significant impact on the SSI rate.
   Conclusions: Endophlebectomy with complementary PTFE AVF of the femoral vein is related to an increased rate of lymphatic leakage and SSI. Lymphatic fistula and the duration of surgery could be assessed as relevant influencing factors of SSI. Application of cINPT in this surgical setting may reduce the SSI rate. Despite this potential improvement, SSI rates still limit the clinical success of a deep venous recanalization.
C1 [Gombert, Alexander; Barbati, Mohammad E.; Houman, Houman Jalaie] Rhein Westfal TH Aachen, European Vasc Ctr Aachen Maastricht, Univ Hosp Aachen, Pauwelsstr 30, D-52074 Aachen, Germany.
   [Van Vuuren, Timme M. A. J.; Toonder, Irwin M.; Van Laanen, Jorinde H. H.; Wittens, Cees] Maastricht Univ Hosp, Univ Hosp Aachen, European Vasc Ctr Aachen Maastricht, Maastricht, Netherlands.
C3 Maastricht University; RWTH Aachen University; RWTH Aachen University
   Hospital; RWTH Aachen University; RWTH Aachen University Hospital;
   Maastricht University; Maastricht University Medical Centre (MUMC)
RP Gombert, A (通讯作者)，Rhein Westfal TH Aachen, European Vasc Ctr Aachen Maastricht, Univ Hosp Aachen, Pauwelsstr 30, D-52074 Aachen, Germany.
EM agombert@ukaachen.de
RI ; Barbati, Mohammad Esmaeil/F-5529-2016; Toonder, Irwin/LSK-9695-2024
OI Gombert, Alexander/0000-0002-8451-2913; Barbati, Mohammad
   Esmaeil/0000-0003-0709-8533; 
CR Allegranzi Benedetta, 2016, Lancet Infect Dis, V16, pe276, DOI [10.1016/s1473-3099(16)30402-9, 10.1016/s1473-3099(16)30398-x, 10.1016/S1473-3099(16)30398-X]
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NR 27
TC 7
Z9 8
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-333X
J9 J VASC SURG-VENOUS L
JI J. Vasc. Surg.-Venous Lymphat. Dis.
PD JAN
PY 2020
VL 8
IS 1
BP 89
EP 94
DI 10.1016/j.jvsv.2019.08.010
PG 6
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA KS3OM
UT WOS:000518221600014
PM 31653533
OA Green Published, Bronze
DA 2026-07-24
ER
PT J
AU De Simone, B
   Sartelli, M
   Coccolini, F
   Ball, CG
   Brambillasca, P
   Chiarugi, M
   Campanile, FC
   Nita, G
   Corbella, D
   Leppaniemi, A
   Boschini, E
   Moore, EE
   Biffl, W
   Peitzmann, A
   Kluger, Y
   Sugrue, M
   Fraga, G
   Di Saverio, S
   Weber, D
   Sakakushev, B
   Chiara, O
   Abu-Zidan, FM
   ten Broek, R
   Kirkpatrick, AW
   Wani, I
   Coimbra, R
   Baiocchi, GL
   Kelly, MD
   Ansaloni, L
   Catena, F
AF De Simone, Belinda
   Sartelli, Massimo
   Coccolini, Federico
   Ball, Chad G.
   Brambillasca, Pietro
   Chiarugi, Massimo
   Campanile, Fabio Cesare
   Nita, Gabriela
   Corbella, Davide
   Leppaniemi, Ari
   Boschini, Elena
   Moore, Ernest E.
   Biffl, Walter
   Peitzmann, Andrew
   Kluger, Yoram
   Sugrue, Michael
   Fraga, Gustavo
   Di Saverio, Salomone
   Weber, Dieter
   Sakakushev, Boris
   Chiara, Osvaldo
   Abu-Zidan, Fikri M.
   ten Broek, Richard
   Kirkpatrick, Andrew W.
   Wani, Imtiaz
   Coimbra, Raul
   Baiocchi, Gian Luca
   Kelly, Micheal D.
   Ansaloni, Luca
   Catena, Fausto
TI Intraoperative surgical site infection control and prevention: a
   position paper and future addendum to WSES intra-abdominal infections
   guidelines
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Emergency; Surgical site infection; Prevention; Intra-abdominal
   infection; Operating room
ID RANDOMIZED CONTROLLED-TRIAL; TRICLOSAN-COATED SUTURES; PRESSURE WOUND
   THERAPY; ABDOMINAL-WALL CLOSURE; SUPPLEMENTAL PERIOPERATIVE OXYGEN;
   SUBCUTANEOUS SUCTION DRAINS; VACUUM-ASSISTED CLOSURE; DELAYED PRIMARY
   CLOSURE; SKIN CLOSURE; GASTROINTESTINAL SURGERY
AB Background Surgical site infections (SSI) represent a considerable burden for healthcare systems. They are largely preventable and multiple interventions have been proposed over past years in an attempt to prevent SSI. We aim to provide a position paper on Operative Room (OR) prevention of SSI in patients presenting with intra-abdominal infection to be considered a future addendum to the well-known World Society of Emergency Surgery (WSES) Guidelines on the management of intra-abdominal infections. Methods The literature was searched for focused publications on SSI until March 2019. Critical analysis and grading of the literature has been performed by a working group of experts; the literature review and the statements were evaluated by a Steering Committee of the WSES. Results Wound protectors and antibacterial sutures seem to have effective roles to prevent SSI in intra-abdominal infections. The application of negative-pressure wound therapy in preventing SSI can be useful in reducing postoperative wound complications. It is important to pursue normothermia with the available resources in the intraoperative period to decrease SSI rate. The optimal knowledge of the pharmacokinetic/pharmacodynamic characteristics of antibiotics helps to decide when additional intraoperative antibiotic doses should be administered in patients with intra-abdominal infections undergoing emergency surgery to prevent SSI. Conclusions The current position paper offers an extensive overview of the available evidence regarding surgical site infection control and prevention in patients having intra-abdominal infections.
C1 [De Simone, Belinda] Azienda USL IRCSS Reggio Emilia, Dept Gen Surg, Guastalla Hosp, Via Donatori Sangue 1, I-42016 Guastalla, RE, Italy.
   [Sartelli, Massimo] Macerata Hosp, Dept Gen Surg, I-62100 Macerata, Italy.
   [Coccolini, Federico] Pisa Univ Hosp, Gen Emergency & Trauma Surg, I-56124 Pisa, Italy.
   [Ball, Chad G.] Univ Calgary, Dept Surg & Oncol Hepatobiliary & Pancreat Surg, Trauma & Acute Care Surg, Foothills Med Ctr, Calgary, AB T2N 2T9, Canada.
   [Brambillasca, Pietro; Corbella, Davide] Papa Giovanni XXIII Hosp, Anesthesia & Crit Care Dept, Pzza OMS 1, I-24128 Bergamo, Italy.
   [Chiarugi, Massimo] Cisanello Hosp, Emergency Surg Unit, Pisa, Italy.
   [Chiarugi, Massimo] Cisanello Hosp, Ctr Trauma, Pisa, Italy.
   [Campanile, Fabio Cesare] Osped Andosilla, Fabio Cesare Campanile, Civita Castellana, Italy.
   [Nita, Gabriela] Castelnuovo NeMonti Hosp, Unit Gen Surg, AUSL, Reggio Emilia, Italy.
   [Leppaniemi, Ari] Univ Helsinki, Abdominal Ctr, Meilahti Hosp, Helsinki, Finland.
   [Boschini, Elena] Papa Giovanni XXIII Hosp, Med Lib, Pzza OMS 1, I-24128 Bergamo, Italy.
   [Moore, Ernest E.] Denver Hlth, Ernest E Moore Shock Trauma Ctr, Denver, CO USA.
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   [Biffl, Walter] Scripps Mem Hosp, Trauma & Acute Care Surg, La Jolla, CA USA.
   [Peitzmann, Andrew] Univ Pittsburgh, Sch Med, Dept Surg, Pittsburgh, PA USA.
   [Kluger, Yoram] Rambam Hlth Care Campus, Div Gen Surg, Haifa, Israel.
   [Sugrue, Michael] Letterkenny Univ Hosp, Dept Surg, Letterkenny, Ireland.
   [Sugrue, Michael] Donegal Clin Res Acad, Letterkenny, Ireland.
   [Fraga, Gustavo] Univ Estadual Campinas, Sch Med Sci, Div Trauma Surg, Campinas, SP, Brazil.
   [Di Saverio, Salomone] Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England.
   [Weber, Dieter] Royal Perth Hosp, Trauma & Gen Surg, Perth, WA, Australia.
   [Sakakushev, Boris] Univ Hosp St George First, Clin Gen Surg, Plovdiv, Bulgaria.
   [Chiara, Osvaldo] State Univ Milan, Acute Care Surg Niguarda Hosp, Milan, Italy.
   [Abu-Zidan, Fikri M.] UAE Univ, Coll Med & Hlth Sci, Dept Surg, Al Ain, U Arab Emirates.
   [ten Broek, Richard] Radboud Univ Nijmegen, Nijmegen, Netherlands.
   [Kirkpatrick, Andrew W.] Foothills Med Ctr, Calgary, AB, Canada.
   [Kirkpatrick, Andrew W.] Univ Calgary, Calgary, AB, Canada.
   [Wani, Imtiaz] Sheri Kashmir Inst Med Sci, Dept Surg, Srinagar, India.
   [Coimbra, Raul] UC San Diego Med Ctr, Dept Surg, San Diego, CA USA.
   [Baiocchi, Gian Luca] Univ Brescia, Dept Surg, Brescia, Italy.
   [Kelly, Micheal D.] Albury Hosp, Dept Gen Surg, Albury, NSW 2640, Australia.
   [Ansaloni, Luca] Bufalini Hosp, Dept Emergency & Trauma Surg, I-47521 Cesena, Italy.
   [Catena, Fausto] Univ Hosp Parma, Dept Emergency & Trauma Surg, I-43100 Parma, Italy.
C3 University of Pisa; Azienda Ospedaliero Universitaria Pisana; University
   of Calgary; University Calgary Hospital; ASST Papa Giovanni XXIII;
   University of Helsinki; Helsinki University Central Hospital; ASST Papa
   Giovanni XXIII; Denver Health Medical Center; University of Colorado
   System; University of Colorado Denver; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); University of Pittsburgh; Technion Israel
   Institute of Technology; Rambam Health Care Campus; Universidade
   Estadual de Campinas; University of Cambridge; East Metropolitan Health
   Service; Royal Perth Hospital; University of Milan; United Arab Emirates
   University; Radboud University Nijmegen; University of Calgary;
   University Calgary Hospital; University of Calgary; Sher-i-Kashmir
   Institute of Medical Sciences; University of California System;
   University of California San Diego; University of Brescia; University of
   Parma; University Hospital of Parma
RP De Simone, B (通讯作者)，Azienda USL IRCSS Reggio Emilia, Dept Gen Surg, Guastalla Hosp, Via Donatori Sangue 1, I-42016 Guastalla, RE, Italy.
EM desimone.belinda@gmail.com
RI Leppäniemi, Ari/GQZ-7991-2022; De Simone, Belinda/AAD-5646-2019;
   /AAD-7440-2020; Broek, Richard/M-9038-2016; Abu-Zidan,
   Fikri/GWE-2835-2022; Sakakushev, Boris/MGV-4913-2025; Chiarugi,
   Massimo/ABQ-7280-2022; Di Saverio, Salomone/G-1437-2012; Ansaloni,
   Luca/AAP-9134-2020; Ansaloni, Luca/AAJ-6507-2020; Coimbra,
   Raul/AAP-3019-2020; Campanile, Fabio Cesare/G-2831-2012; chiara,
   osvaldo/R-6151-2018
OI BAIOCCHI, Gian Luca/0000-0003-2402-2178; Sakakushev,
   Boris/0000-0001-8399-0115; Chiarugi, Massimo/0000-0001-6905-2499; Di
   Saverio, Salomone/0000-0001-5685-5022; Ansaloni,
   Luca/0000-0001-6427-0307; Kong, Victor/0000-0003-2291-2572; Ansaloni,
   Luca/0000-0001-6427-0307; Coimbra, Raul/0000-0002-3759-6851; Campanile,
   Fabio Cesare/0000-0003-3830-634X; chiara, osvaldo/0000-0003-2409-2109
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NR 136
TC 84
Z9 91
U1 1
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD FEB 10
PY 2020
VL 15
IS 1
AR 10
DI 10.1186/s13017-020-0288-4
PG 23
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA KT5VO
UT WOS:000519082800001
PM 32041636
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kaufman, R
   Nguyen, J
   Williams, B
   Patel, S
   Lopez, R
   Boc, SF
AF Kaufman, Richard
   Nguyen, Joshua
   Williams, Brett
   Patel, Sunny
   Lopez, Ramon
   Boc, Steven F.
TI Treatment of Traumatic Degloving Injury of the Foot Using a Biologic
   Dressing in a Pediatric Patient
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE degloving injury; trauma; foot; surgical; pediatric; dermal regeneration
   template; wound matrix; biological dressing; soft tissue damage
ID PRESSURE WOUND THERAPY; RECONSTRUCTION; MANAGEMENT; INTEGRA
AB Introduction. Degloving injuries of the foot involve the management of extensive soft tissue and osseous damage secondary to significant forced avulsion of soft tissue, which can present a major challenge for the surgeon. Surgical procedures on pediatric foot degloving involving split-thickness and/or full-thickness skin grafts and rotational flaps can result in negative consequences, such as donor site comorbidities and psychosocial implications when the pediatric patient returns to daily life. Case Report. The authors report the case of a 16-year-old girl with no past medical history who sustained an extensive degloving injury to her right foot involving severe subcutaneous and muscular soft tissue disruption and contamination. The initial treatment consisted of debridement, copious irrigation, primary wound closure at several sites, and application of an extracellular matrix (ECM) substitute graft. Shortly thereafter, secondary treatment consisted of application of primary musculoskeletal repair, negative pressure wound therapy (NPWT), and application of a dermal regeneration template. Over the 5-month course of treatment, an additional 3 trips to the operating room occurred, involving serial irrigation and debridement, NPWT application, and dermal/ECM substitute graft applications, leading to full epithelialization. Conclusions. To the best of the authors knowledge, this is the first reported case in which an instance of pediatric foot degloving is presented with serial debridement, NPWT, and biological dressings, resulting in no additional plastic surgical techniques needed to provide return to functional outcome.
C1 [Kaufman, Richard] Ankle & Foot Ctr Georgia, 865 Holcomb Bridge, Roswell, GA 30076 USA.
   [Kaufman, Richard] Piedmont Atlanta Hosp, Atlanta, GA USA.
   [Nguyen, Joshua] Rosalind Franklin Univ Med & Sci, Dr William M Scholl Coll Podiatr Med, N Chicago, IL USA.
   [Williams, Brett] Foot & Ankle Ctr Philadelphia, Philadelphia, PA USA.
   [Patel, Sunny] Achilles Foot & Ankle Ctr, Henrico, VA USA.
   [Lopez, Ramon; Boc, Steven F.] Hahnemann Univ Hosp DUCOM, Philadelphia, PA USA.
C3 Rosalind Franklin University of Medicine & Science
RP Kaufman, R (通讯作者)，Ankle & Foot Ctr Georgia, 865 Holcomb Bridge, Roswell, GA 30076 USA.
EM kaufmandpm@ankleandfootcenters.com
RI Kaufman, Richard/E-8890-2018; /AAJ-6188-2021
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NR 23
TC 4
Z9 5
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2019
VL 31
IS 11
BP E77
EP E81
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KU5IM
UT WOS:000519743900002
PM 31876514
DA 2026-07-24
ER
PT J
AU Cuendis-Velázquez, A
   Trejo-Avila, M
   Arce-Liévano, E
   Cárdenas-Lailson, E
   Sanjuan-Martínez, C
   Moreno-Portillo, M
AF Cuendis-Velazquez, Adolfo
   Trejo-Avila, Mario
   Arce-Lievano, Elisafat
   Cardenas-Lailson, Eduardo
   Sanjuan-Martinez, Carlos
   Moreno-Portillo, Mucio
TI A Four-step Technique for Effluent Diversion of Enteroatmospheric
   Fistulas
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE enteroatmospheric fistula; open abdomen; vacuum-assisted closure;
   negative pressure wound therapy; NPWT
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; OPEN ABDOMEN;
   ENTEROCUTANEOUS FISTULAS; MANAGEMENT; GUIDELINES; SYSTEM
AB Background. Isolation of the enteroatmospheric fistula (EAF) opening and prevention of contamination of the rest of the wound by effluent are important factors in the management of EAF. Objective. The aim of this study is to describe an easily reproducible technique for effluent control in patients with EAF. Materials and Methods. A retrospective analysis was conducted on all patients who underwent the present technique between 2013 and 2015. The surgical technique included condom-EAF anastomosis, fistula ring creation, negative pressure wound therapy (NPWT), and adaptation of an ostomy bag. Results. A total of 7 patients with a Bjorck grade 4 abdomen were included. All fistulas were located in the small bowel with a median number of 2 EAFs (range, 2-3) in each patient, and the majority had moderate output volume. The mean number of NPWT changes was 10 (range, 5-18), the mean time of NPWT use was 75.7 days (range,60-120 days), and the mean length of stay was 108.2 days (range, 103-160 days). The mean time of ostomy formation to restitution of bowel continuity was 14.3 months (range, 8-20 months). Open anterior component separation was employed in all cases for closure of the abdominal wall. No mortality, ventral herniation, or refistulization was registered in the study. The mean follow-up time was 8.5 months(range, 6-12 months). Conclusions. This is an easily reproducible and safe technique for effluent control in patients with Bjork grade 4 abdomen with established EAF.
C1 [Cuendis-Velazquez, Adolfo; Trejo-Avila, Mario; Arce-Lievano, Elisafat; Cardenas-Lailson, Eduardo; Sanjuan-Martinez, Carlos; Moreno-Portillo, Mucio] Hosp Gen Dr Manuel Gea Gonzalez, Dept Gen & Endoscop Surg, Calzada Tlalpan 4800, Mexico City 14090, DF, Mexico.
RP Trejo-Avila, M (通讯作者)，Hosp Gen Dr Manuel Gea Gonzalez, Dept Gen & Endoscop Surg, Calzada Tlalpan 4800, Mexico City 14090, DF, Mexico.
EM mario.trejo.avila@gmail.com
RI /AAH-2910-2020
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   Verhaalen A, 2010, WOUNDS, V22, P212
   Wang GF, 2013, J TRAUMA ACUTE CARE, V74, P1175, DOI 10.1097/TA.0b013e318282705e
   Yetisir F, 2017, HERNIA, V21, P809, DOI 10.1007/s10029-017-1614-y
NR 25
TC 2
Z9 4
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2019
VL 31
IS 11
BP 285
EP 291
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KU5IM
UT WOS:000519743900005
PM 31730510
DA 2026-07-24
ER
PT J
AU Semenic, D
   Bukovec, P
AF Semenic, Danijela
   Bukovec, Petra
TI Advanced Treatment Options of Pyoderma Gangrenosum Ulcers
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE immunosuppression; negative pressure wound therapy; pyoderma
   gangrenosum; surgery; ulcer
ID PLATELET-RICH PLASMA; PRESSURE WOUND THERAPY; SURGICAL-TREATMENT;
   UPDATE; MODEL; RISK; GEL
AB Introduction. Pyoderma gangrenosum (PG) is a neutrophilic dermatosis often associated with autoimmune disease that, despite published literature, still poses diagnostic and therapeutic challenges due to its lack of serological and histological markers and wide possibility of differential diagnosis. Although immunosuppressive therapy usually is the first-line treatment, it has a long-lasting, unpredictable treatment course, thus necessitating the need for new treatment options. This report highlights 2 cases of PG ulcers treated with different methods that show a potentially faster healing time, as well as a review of advanced treatment options for PG. Case Reports. Two men (21 years old and 64 years old) presented with PG ulcers and underwent 2 different treatment courses. The 21-year-old man received negative pressure wound therapy (NPWT) with a nonadhesive, less-invasive, skin-contact interface layer on the polyurethane foam. Stimulated growth of granulation tissue accelerated healing and prepared the wound bed for further epithelization. The second patient, the 64-yearold man, underwent treatment with autologous platelet-rich fibrin, which supplied the ulcer with growth factors and accelerated epithelialization. Conclusions. The new possibilities offered by NPWT with nonadhesive foam and regenerative medicine are typically affordable, effective, safe, and painless for the patient. Both methods were noninvasive, did not accelerated the pathergy phenomenon, and showed a potential for faster healing of PG ulcers.
C1 Univ Ljubljana, Dept Surg Infect, Univ Med Ctr Ljubljana, Ljubljana, Slovenia.
   Univ Ljubljana, Med Fac, Ljubljana, Slovenia.
C3 University of Ljubljana; University Medical Centre Ljubljana; University
   of Ljubljana
RP Semenic, D (通讯作者)，Univ Med Ctr Ljubljana, Dept Surg Infect, Zaloska Cesta 7, Ljubljana 1000, Slovenia.
EM danijela.semenic@kclj.si
CR Ahmed M, 2017, ANN VASC SURG, V38, P206, DOI 10.1016/j.avsg.2016.04.023
   Alavi A, 2017, AM J CLIN DERMATOL, V18, P355, DOI 10.1007/s40257-017-0251-7
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   Leitsch Sebastian, 2016, Wounds, V28, pE10
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   Zuo KJ, 2015, J PLAST RECONSTR AES, V68, P295, DOI 10.1016/j.bjps.2014.12.036
NR 29
TC 3
Z9 3
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2020
VL 32
IS 2
BP E1
EP E5
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KU5JC
UT WOS:000519745700001
PM 32155124
DA 2026-07-24
ER
PT J
AU Klein, RJ
AF Klein, Robert J.
TI Use of Oxidized Regenerated Cellulose (ORC)/Collagen/Silver-ORC
   Dressings Alone or Subsequent to Advanced Wound Therapies in Complex
   Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE oxidized regenerated cellulose; collagen; silver; dressings; negative
   pressure wound therapy; diabetic foot ulcer; traumatic wound; surgical
   dehiscence
ID MINIMALLY INVASIVE TOOL; TISSUE
AB Introduction. Chronic or senescent wounds are difficult to heal and often require a multi modal treatment plan. Negative pressure wound therapy (NPWT) or advanced wound dressings, such as oxidized regenerated cellulose (ORC)/collagen/ silver-ORC dressings, can be used to promote granulation tissue development and stimulate wound healing in these complex wounds. Objective. This article examines the use of ORC/collagen/silver-ORC dressings alone or subsequent to advanced wound therapies in a retrospective cohort of 24 patients.Materials and Methods. Wounds were assessed upon presentation. If necessary, oral and/or intravenous antibiotics were administered.Each wound underwent sharp debridement. Patients received either ORC/collagen/silver-ORC dressings with a secondary dressing alone or following NPWT. Skin substitutes and epidermal grafting also were utilized to promote wound healing and wound size reduction.Results. Twenty-four patients with an average age of 66.8 +/- 12.7 years were treated. The most prevalent comorbidities were hypertension,diabetes, obesity, peripheral neuropathy, hyperlipidemia, coronary heart disease, and tobacco use. Wound types (N = 27) included diabetic foot ulcers, surgical wounds, traumatic wounds, an ulcer (secondary to chronic gout with tophi), and thermal burns. All 27 wounds fully closed, with an average time to heal of 65.5 +/- 41.5 days. Conclusions. Use of advanced treatment modalities including NPWT, epidermal grafting, and ORC/collagen/silver-ORC dressings contributed to wound healing in these patients with complex and/or chronic wounds.
C1 [Klein, Robert J.] Collom & Carney Clin Assoc, Texarkana, TX USA.
   [Klein, Robert J.] Prisma Hlth, Greenville, SC USA.
C3 Prisma Health
RP Klein, RJ (通讯作者)，200 Patewood Dr,Suite C300, Greenville, SC 29615 USA.
EM robklein63@gmail.com
CR Alavi A, 2010, ADV SKIN WOUND CARE, V23, P132, DOI 10.1097/01.ASW.0000363515.09394.66
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   Younes Nidal, 2006, Dermatol Online J, V12, P5
NR 30
TC 6
Z9 7
U1 0
U2 11
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2020
VL 32
IS 2
BP 37
EP 43
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KU5JC
UT WOS:000519745700002
PM 32155120
DA 2026-07-24
ER
PT J
AU Liu, XX
   Kaminsky, AJ
   Hill, DM
   Velamuri, SR
AF Liu, Xiangxia
   Kaminsky, Alexander J.
   Hill, David M.
   Velamuri, Sai R.
TI Heterotopic ossification: a preventable case of gossypiboma in spinal
   cord injury
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE heterotopic ossification; gossypiboma; negative wound pressure therapy;
   spinal cord injury
ID RISK-FACTORS; ASSOCIATION; RADIOTHERAPY; RADIATION; SPONGE; BONE
AB Objective: Heterotopic ossification is the formation of ectopic bone in soft tissues. It has three established aetiologies: genetic, traumatic and neurogenic. A gossypiboma is defined as a retained foreign body, such as a mass or sponge, usually after a surgical procedure. In this article, we present a unique, preventable case of a patient admitted for newly developed heterotopic ossification in the gluteus maximus muscle caused by a retained piece of foam from negative pressure wound therapy (NPWT). The heterotopic ossification lesion, together with the retained foreign body, was completely excised and reconstructed using a posterior thigh fasciocutaneous advancement flap. This is the first reported case of heterotopic ossification caused by a retained foreign body and may be helpful to better understanding of the aetiology of heterotopic ossification.
C1 [Liu, Xiangxia; Kaminsky, Alexander J.; Velamuri, Sai R.] Univ Tennessee, Ctr Hlth Sci, Dept Plast Surg, Memphis, TN 38163 USA.
   [Liu, Xiangxia] Sun Yat Sen Univ, Affiliated Hosp 1, Div Plast Surg, Guangzhou, Peoples R China.
   [Hill, David M.] Firefighters Burn Ctr, Dept Pharm, Reg One Hlth, Memphis, TN USA.
   [Hill, David M.] Univ Tennessee, Ctr Hlth Sci, Dept Clin Pharm, Coll Pharm, Memphis, TN 38163 USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center; Sun Yat Sen University; University of Tennessee System;
   University of Tennessee Health Science Center
RP Kaminsky, AJ (通讯作者)，Univ Tennessee, Ctr Hlth Sci, Dept Plast Surg, Memphis, TN 38163 USA.
EM alexkaminsky@gmail.com
RI /AAI-2609-2019
OI Hill, David/0000-0002-1119-1901
CR Ahmed F, 2010, J PLAST RECONSTR AES, V63, pE497, DOI 10.1016/j.bjps.2009.09.006
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   Banovac K, 2001, SPINAL CORD, V39, P370, DOI 10.1038/sj.sc.3101166
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   Citak M, 2011, Z ORTHOP UNFALLCHIR, V149, P90, DOI 10.1055/s-0030-1250688
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   Hallock GG, 2008, PLAST RECONSTR SURG, V122, p84E, DOI 10.1097/PRS.0b013e31817d6528
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   McCarthy EF, 2005, SKELETAL RADIOL, V34, P609, DOI 10.1007/s00256-005-0958-z
   Milakovic M, 2015, RADIOTHER ONCOL, V116, P4, DOI 10.1016/j.radonc.2015.05.022
   Naraghi FF, 1996, ORTHOPEDICS, V19, P145
   Ohlmeier M, 2017, SPINE J, V17, P1519, DOI 10.1016/j.spinee.2017.04.021
   Oleson CV, 2013, J REHABIL RES DEV, V50, P1177, DOI 10.1682/JRRD.2012.11.0206
   Ploumis A, 2015, J SPINAL CORD MED, V38, P193, DOI 10.1179/2045772314Y.0000000213
   Ranganathan K, 2015, J BONE JOINT SURG AM, V97A, P1101, DOI 10.2106/JBJS.N.01056
   Rencuzogullari A, 2015, INT WOUND J, V12, P739, DOI 10.1111/iwj.12200
   Rosteius T, 2017, SPINAL CORD, V55, P71, DOI 10.1038/sc.2016.93
   Sakellariou VI, 2012, J MUSCULOSKEL NEURON, V12, P230
   Teasell RW, 2010, SPINAL CORD, V48, P512, DOI 10.1038/sc.2009.175
   van Kuijk AA, 2002, SPINAL CORD, V40, P313, DOI 10.1038/sj.sc.3101309
   Yang K, 2017, J PLAST RECONSTR AES, V70, P518, DOI 10.1016/j.bjps.2016.11.026
   Zhang RR, 2013, BONE, V52, P145, DOI 10.1016/j.bone.2012.09.029
NR 31
TC 1
Z9 1
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR 2
PY 2020
VL 29
IS 3
SU 3
BP S30
EP S32
DI 10.12968/jowc.2020.29.Sup3.S30
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA KU7LR
UT WOS:000519895100005
PM 32160126
DA 2026-07-24
ER
PT J
AU Biermann, N
   Geissler, EK
   Brix, E
   Schiltz, D
   Muehle, C
   Prantl, L
   Taeger, CD
AF Biermann, Niklas
   Geissler, Edward K.
   Brix, Eva
   Schiltz, Daniel
   Muehle, Clemens
   Prantl, Lukas
   Taeger, Christian D.
TI Pressure distribution and flow characteristics during negative pressure
   wound therapy
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Negative pressure wound therapy; Perfusion; Flow; Pressure
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; LASER-DOPPLER;
   MECHANISMS
AB Aim of the study: Negative pressure wound therapy is thought to improve wound healing by altering capillary perfusion. However, despite many theories, the underlying mechanism of action remains controversial. Recent evidence suggests an increased tissue pressure and a temporary decreased microvascular blood flow as the main reasons for the good clinical results [1]. In an attempt to further explain the mechanism of action, we investigated the pressure distribution on the foam interface, and the influence on perfusion in a pre-experimental design.
   Materials and methods: Pressure distribution was measured using a sensor based on a capacitive dielectric elastomer with flexible electrodes. In vitro flow measurements were done with vessel imitations in a block of 300 bloom ballistic gel to simulate soft tissue.
   Results: A peak pressure of up to 187 mmHg (255 g/cm2) within the foam interface, as well as decreased perfusion, were found using a standard negative pressure wound therapy setup. In conclusion, negative pressure wound therapy applies positive pressure to adjacent tissue and decreases local flow. The amount of suction applied is proportional to the pressure on the foam interface and reduction in flow.
   Conclusion: In line with previous studies investigating the underlying mechanism of action, these findings may contribute to possible alterations in the use of negative pressure wound therapy, e.g. lowering suction pressure in patients with diminished peripheral blood flow.
C1 [Biermann, Niklas; Brix, Eva; Schiltz, Daniel; Muehle, Clemens; Prantl, Lukas; Taeger, Christian D.] Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, Regensburg, Germany.
   [Geissler, Edward K.] Univ Hosp Regensburg, Dept Surg, Regensburg, Germany.
C3 University of Regensburg; University of Regensburg
RP Taeger, CD (通讯作者)，Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, Regensburg, Germany.
EM christian.taeger@ukr.de
RI Schiltz, Daniel/HJP-4834-2023; Geissler, Edward/R-4131-2016; prantl,
   Lukas/AAM-1848-2021
OI Schiltz, Daniel/0000-0003-1096-9336; prantl, Lukas/0000-0003-2454-2499
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Au YH, 2019, INT WOUND J, V16, P550, DOI 10.1111/iwj.13112
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NR 32
TC 19
Z9 21
U1 2
U2 19
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2020
VL 29
IS 1
BP 32
EP 36
DI 10.1016/j.jtv.2019.12.004
PG 5
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA KV6RS
UT WOS:000520610200007
PM 31899070
DA 2026-07-24
ER
PT J
AU Mohammed, AH
   Hamed, SA
   Abdelghany, AI
AF Mohammed, Ashraf H.
   Hamed, Somia Ali
   Abdelghany, Abdelrhman Ismail
TI Comparison between two different protocols of negative pressure therapy
   for healing of chronic ulcers
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Wound healing; Negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; SUCTION DRAINAGE; INSTILLATION;
   MANAGEMENT; TRIAL; FOAM
AB Background: Negative pressure therapy plays an important role in the healing process of different types of wounds. Aim of the study: this study aimed to compare between modified and traditional method of vacuum wound closure for chronic wounds.
   Subjects: Thirty participants with chronic ulcers completed the study, their ages ranged from 47 to 65 years, from Benha city, divided randomly into two groups, it was carried out from December 2017 to March 2019.
   Methods: The first group treated by the traditional method of vacuum assisted wound closure for 8 weeks; dressing was changed 3 times weekly, at 125 mmHg. The mode of 2 min off and 5 min on was used. The second group treated by the modified method by switching off the device at the fifth week and applying traditional dressing for one week then ended by three weeks of vacuum wound closure. Assessment was performed before and after the study. Student t-test was used for analysis.
   Result: Paired t-test showed a significant improvement in wound surface area as well as volume for pre and post treatment in each group (p < 0.05). On the other hand independent t-test revealed a non-significant difference between the two groups pre as well as post treatment (p > 0.05).
   Conclusion: There is no significant difference between the two programs on healing of chronic ulcers.
C1 [Mohammed, Ashraf H.] Cairo Univ, Cairo, Egypt.
   [Hamed, Somia Ali] October 6 Univ, Cairo, Egypt.
   [Mohammed, Ashraf H.; Abdelghany, Abdelrhman Ismail] Badr Univ, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); October 6 University (O6U); Badr University in Cairo
RP Mohammed, AH (通讯作者)，Badr Univ Cairo, Cairo Univ, Cairo, Egypt.
EM ashraf.hassan@buc.edu.eg
RI ; Hamed, Somaia/ABD-4373-2020
OI mohammed, ashraf/0000-0003-4223-1483; Hamed, Somaia/0000-0001-9794-7353
CR [Anonymous], E PLASTY
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NR 26
TC 3
Z9 3
U1 0
U2 4
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2020
VL 29
IS 1
BP 37
EP 41
DI 10.1016/j.jtv.2019.10.003
PG 5
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA KV6RS
UT WOS:000520610200008
PM 31677995
DA 2026-07-24
ER
PT J
AU Mori, RV
   Gonzalez, YM
   Carballal, MM
   Ruiz, CG
   Ruiz, GP
   Arias, AE
   Kissler, JJO
AF Villalobos Mori, R.
   Maestre Gonzalez, Y.
   Mias Carballal, Ma
   Gas Ruiz, C.
   Protti Ruiz, G.
   Escartin Arias, A.
   Olsina Kissler, J. J.
TI Novel method for delayed primary closure and incisional hernia
   prevention in open abdomen: COmbined and MOdified Definitive Abdominal
   wall closure (COMODA)
SO HERNIA
LA English
DT Article
DE Open abdomen; Incisional hernia; Primary closure; Intra-abdominal
   pressure
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; TEMPORARY CLOSURE;
   COMPARTMENT SYNDROME; FASCIAL CLOSURE; PACK TECHNIQUE; MANAGEMENT; MESH;
   EXPERIENCE; TRACTION
AB Background Intended open abdomen is an option in cases of trauma and non-trauma patients. Nevertheless, after primary closure, incisional hernia rate is high. We describe a novel method, called COmbined and MOdified Definitive Abdominal closure (COMODA), a delayed primary closure which prevents incisional hernia. Methods A negative pressure wound therapy system is combined with a condensed polytetrafluoroethylene (cPTFE) mesh. Trial registration: ISRCTN72678033. Results Ten male patients with a median age of 68.8 (43-87) years were included. Primary closure rate was 100% per protocol. The median number of procedures per patient was 5.7 (5-9). Primary closure was obtained in 20.8 (10-32) days and median hospital stay was 36.3 (18-52) days. Only one patient developed incisional hernia during a median follow-up of 27 (8-60) months. Conclusion COMODA method allows for a high rate of delayed primary closure. It is safe and decreases the risk for developing an incisional hernia. However, a large number of patients are needed to support this conclusion.
C1 [Villalobos Mori, R.; Maestre Gonzalez, Y.; Mias Carballal, Ma; Gas Ruiz, C.; Protti Ruiz, G.; Escartin Arias, A.; Olsina Kissler, J. J.] Lleida Univ, Dept Gen Surg, Abdominal Wall Surg Unit, Arnau de Vilanova Univ Hosp, 80 Rovira Roure Ave, Lleida 25198, Catalonia, Spain.
C3 Universitat de Lleida
RP Mori, RV (通讯作者)，Lleida Univ, Dept Gen Surg, Abdominal Wall Surg Unit, Arnau de Vilanova Univ Hosp, 80 Rovira Roure Ave, Lleida 25198, Catalonia, Spain.
EM rafovilla26@gmail.com; yomago@hotmail.com; mcmias.lleida.ics@gencat.cat;
   crisgas6@gmail.com; gianpier@gmail.com; escartin@mac.com;
   jjolsina@gmail.com
RI ESCARTIN, ALFREDO/E-2823-2012
OI ESCARTIN, ALFREDO/0000-0002-5234-2366
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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   Carlson GL, 2013, ANN SURG, V257, P1154, DOI 10.1097/SLA.0b013e31828b8bc8
   Cheatham ML, 2013, WORLD J SURG, V37, P2018, DOI 10.1007/s00268-013-2080-z
   Cheesborough JE, 2016, AM J SURG, V211, P1, DOI 10.1016/j.amjsurg.2015.03.033
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NR 41
TC 6
Z9 10
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2020
VL 24
IS 2
SI SI
BP 395
EP 401
DI 10.1007/s10029-019-01948-2
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KW4SU
UT WOS:000521156600022
PM 30968285
DA 2026-07-24
ER
PT J
AU Cao, J
   Liu, ZX
   Ma, DY
   Shen, SY
   Wang, XD
AF Cao, Jian
   Liu, Zhixu
   Ma, Dongyang
   Shen, Shunyao
   Wang, Xudong
TI Modified Usage of Negative Pressure Wound Therapy for the Management of
   Severe Deep Fascial Space Infections in the Head and Neck
SO INFECTION AND DRUG RESISTANCE
LA English
DT Article
DE negative pressure wound therapy; severe deep fascial space infections;
   modified usage; head and neck
ID VACUUM-ASSISTED CLOSURE
AB Purpose: Although negative pressure wound therapy (NPWT) has been widely used in complicated wound care, there are still some obstacles regarding its use in the treatment of severe deep fascial space infections in the head and neck. The purpose of this study is to describe a new modified usage of NPWT and investigate the clinical efficacy of this system in a consecutive case series of severe deep fascial space infections.
   Methods: The investigators implemented a new modification of NPWT for the management of severe deep fascial space infections. In this new system, the half-plugged bar-shaped foam material was arranged along with the through-and-through side-holed latex drainage tube, which could maintain negative pressure in the distal part of the spaces, and the tube was easy to remove 5-7 days after surgery. Twelve patients had severe deep fascial space infections in the head and neck with a direct threat to the airway. The median time of removal of the NPWT device, the median amount of drainage fluid and the median healing time were investigated.
   Results: A total of 7 male and 5 female patients with an average age of 63.2 years old were included in this study. The median time of removal of the NPWT device was 6 days (ranging from 4 to 7 days). The median amount of drainage fluid within 3 days after surgery was 420 mL (ranging from 280-760 mL), and the median time for complete wound healing was 12 days (ranging from 10 to 21 days).
   Conclusion: The results of this study suggest that the modification of NPWT provides various advantages and leads to excellent clinical outcomes in the treatment of severe deep fascial space infections. Future studies will focus on the safety verification of portable usage and the cost effectiveness analysis of NPWT.
C1 [Cao, Jian; Liu, Zhixu; Shen, Shunyao; Wang, Xudong] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Oral & Craniomaxillofacial Surg, Coll Stomatol,Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
   [Cao, Jian; Liu, Zhixu; Shen, Shunyao; Wang, Xudong] Natl Clin Res Ctr Oral Dis, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
   [Cao, Jian; Liu, Zhixu; Shen, Shunyao; Wang, Xudong] Shanghai Key Lab Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
   [Cao, Jian; Liu, Zhixu; Shen, Shunyao; Wang, Xudong] Shanghai Res Inst Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
   [Cao, Jian; Ma, Dongyang] 940th Hosp Peoples Liberat Army, Dept Oral & Maxillofacial Surg, Lanzhou, Gansu, Peoples R China.
C3 Shanghai Jiao Tong University
RP Wang, XD (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Oral & Craniomaxillofacial Surg, Coll Stomatol,Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.; Wang, XD (通讯作者)，Natl Clin Res Ctr Oral Dis, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.; Wang, XD (通讯作者)，Shanghai Key Lab Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.; Wang, XD (通讯作者)，Shanghai Res Inst Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
EM xudongwang70@hotmail.com
FU Ninth People's Hospital affiliated to Shanghai JiaoTong University,
   School of Medicine "Multi-Disciplinary Team" Clinical Research Project
   [2017-1-005]; Integrated Fund Project of Ninth People's Hospital;
   Clinical Research Plan of SHDC [16CR3019A]; Interdisciplinary Program of
   Shanghai Jiao Tong University [YG2017ZD03]
FX This study was supported by Ninth People's Hospital affiliated to
   Shanghai JiaoTong University, School of Medicine "Multi-Disciplinary
   Team" Clinical Research Project (2017-1-005), the Integrated Fund
   Project of Ninth People's Hospital, the Clinical Research Plan of SHDC
   (16CR3019A), and the Interdisciplinary Program of Shanghai Jiao Tong
   University (YG2017ZD03).
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NR 17
TC 13
Z9 15
U1 1
U2 11
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2020
VL 13
BP 781
EP 788
DI 10.2147/IDR.S243794
PG 8
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA KX0GE
UT WOS:000521560800001
PM 32210592
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pan, T
   Li, K
   Fan, FD
   Gao, YS
   Wang, DJ
AF Pan, Tuo
   Li, Kai
   Fan, Fu-Dong
   Gao, Yong-Shun
   Wang, Dong-Jin
TI Vacuum-assisted closure vs. bilateral pectoralis major muscle
   flaps for deep sternal wounds infection
SO JOURNAL OF THORACIC DISEASE
LA English
DT Article
DE Deep sternal wound infection (DSWI); vacuum-assisted closure therapy;
   bilateral pectoralis major muscle flaps (BPMMFs)
ID RISK-FACTORS; STERNOTOMY; THERAPY; MEDIASTINITIS; MANAGEMENT;
   RECONSTRUCTION; COMPLICATIONS
AB Background: Deep sternal wound infection (DSWI) is a life-threatening complication after cardiac surgery. The aim of this study was to retrospectively evaluate the outcomes of reconstructing infected poststernotomy wounds with either vacuum-assisted closure (VAC) after previous debridement or bilateral pectoralis major muscle flaps (BPMMFs).
   Methods: In total, 565 patients with postoperative DSWI were enrolled in this study from January 1, 2014, to June 1, 2018. Of these patients, 247 received BPMMFs. To address the indicated biases, a 1:1 propensity score-matched cohort was created based on age, body mass index, preoperative diabetes mellitus, chronic obstructive pulmonary disease (COPD), internal thoracic artery grafting (ITAG), type of cardiac surgery, time before treatment for DSWI and wound classification. After matching, 132 patients who had similar risk profiles were enrolled in the study population (66 in the VAC group: 66 in the BPMMF group).
   Results: At 21.9 +/- 12.1 (median: 24, IQR: 14-28) months of follow-up, the survival rate was 93.9% in the BPMMF group and 74.4% in the VAC group (P<0.01). Compared with the VAC group, the BPMMF group had a significantly decreased length of hospital stay (P<0.01). At the spirometry assessment, the forced expiratory volume in the 1st second (FEV1), vital capacity (VC), and FEV1/VC ratio showed no significant differences in survival between the VAC group and BPMMF group.
   Conclusions: In our study, compared with VAC therapy, BPMMFs guaranteed better early- and late-term outcomes, as shown by less length of hospital stay, a higher rate of long-term survival and unimpaired respiratory function.
C1 [Pan, Tuo; Li, Kai; Fan, Fu-Dong; Wang, Dong-Jin] Nanjing Univ, Affiliated Hosp, Med Sch, Nanjing Drum Tower Hosp,Dept Cardiothorac Surg, Nanjing 210008, Peoples R China.
   [Gao, Yong-Shun] Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Cardiovasc Surg, 5 Nanmencang, Beijing 100010, Peoples R China.
C3 Nanjing University; Chinese People's Liberation Army General Hospital
RP Gao, YS (通讯作者)，Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Cardiovasc Surg, 5 Nanmencang, Beijing 100010, Peoples R China.; Wang, DJ (通讯作者)，Nanjing Drum Tower Hosp, Dept Cardiothorac Surg, 321 Zhongshan Rd, Nanjing 210008, Peoples R China.
EM Yongshun_Gao@126.com; dongjin_wang@126.com
OI , Kai/0009-0006-4764-5430
CR Baillot R, 2010, EUR J CARDIO-THORAC, V37, P880, DOI 10.1016/j.ejcts.2009.09.023
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NR 27
TC 8
Z9 11
U1 0
U2 0
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2072-1439
EI 2077-6624
J9 J THORAC DIS
JI J. Thorac. Dis.
PD MAR
PY 2020
VL 12
IS 3
BP 866
EP 875
DI 10.21037/jtd.2019.12.76
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA KX2UJ
UT WOS:000521736500083
PM 32274154
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Famiglietti, A
   Lazar, JF
   Henderson, H
   Hamm, M
   Malouf, S
   Margolis, M
   Watson, TJ
   Khaitan, PG
AF Famiglietti, Amber
   Lazar, John F.
   Henderson, Hayley
   Hamm, Margaret
   Malouf, Stefanie
   Margolis, Marc
   Watson, Thomas J.
   Khaitan, Puja Gaur
TI Management of anastomotic leaks after esophagectomy and gastric pull-up
SO JOURNAL OF THORACIC DISEASE
LA English
DT Review
DE Esophagectomy; anastomotic leak; endoluminal stent; endoluminal
   vacuum-assisted closure (EVAC); over-the-scope clips (OTSCs);
   endoluminal suturing
ID ENDOSCOPIC VACUUM THERAPY; UPPER GASTROINTESTINAL-TRACT; ASSISTED
   CLOSURE; IVOR-LEWIS; TREATMENT OPTIONS; METAL STENT; PERFORATIONS;
   DEFECTS; COMPLICATIONS; MULTICENTER
AB Anastomotic leak is one of the most feared complications of esophagectomy, leading to prolonged hospital stay, increased postoperative mortality, and additional cost both to the patient and the hospital. Historically, anastomotic leaks have been treated with several techniques including conservative measures, percutaneous or operative drainage, primary surgical repair with buttressing, T-tube drainage, or excision of the esophageal replacement conduit with end esophagostomy. With advances in treatment modalities, including endoscopic stenting, clips and suturing, endoluminal vacuum-assisted closure (EVAC), such leaks increasingly are being managed without operative re-intervention and with salvage of the esophageal replacement conduit. For the purposes of this review, we identified studies analyzing the management of postoperative leak after esophagectomy. We then compared the efficacy of the various newer modalities for closure of anastomotic leaks and gastric conduit defects. We found both esophageal stent and EVAC sponges arc effective treatments for closure of anastomotic leak. The chosen treatment modality for salvage of the esophageal replacement conduit is entirely dependent on the patient's clinical status and the surgeon's preference and experience. Emerging endoscopic and endoluminal therapies have increased the armamentarium of tools the esophageal surgeon has to facilitate successful resolution of anastomotic leaks following esophagectomy with reconstruction. While some literature suggests that EVACs have a slightly superior result in conduit success, we question this endorsement as EVACs mostly are utilized for contained leaks, many of which may have healed with conservative measures. This posses a challenge as there is dearly a bias given patient selection.
C1 [Famiglietti, Amber; Lazar, John F.; Henderson, Hayley; Hamm, Margaret; Malouf, Stefanie; Margolis, Marc; Watson, Thomas J.; Khaitan, Puja Gaur] Georgetown Univ, Sch Med, MedStar Washington Hosp Ctr, Dept Surg, Washington, DC USA.
   [Lazar, John F.; Henderson, Hayley; Hamm, Margaret; Malouf, Stefanie; Margolis, Marc; Watson, Thomas J.; Khaitan, Puja Gaur] Georgetown Univ, Sch Med, MedStar Washington Hosp Ctr, Div Thorac & Esophageal Surg, Washington, DC USA.
C3 Georgetown University; MedStar Washington Hospital Center; Georgetown
   University; MedStar Washington Hospital Center
RP Khaitan, PG (通讯作者)，Georgetown Univ, Sch Med, MedStar Washington Hosp Ctr, Div Thorac & Esophageal Surg,Dept Surg, 110 Irving St NW G253, Washington, DC 20010 USA.
EM Puja.G.Khaitan@medstar.net
RI Khaitan, Puja/AAQ-6413-2020
OI Khaitan, Puja/0000-0001-8654-062X
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NR 49
TC 41
Z9 48
U1 0
U2 1
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2072-1439
EI 2077-6624
J9 J THORAC DIS
JI J. Thorac. Dis.
PD MAR
PY 2020
VL 12
IS 3
BP 1022
EP 1030
DI 10.21037/jtd.2020.01.15
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA KX2UJ
UT WOS:000521736500100
PM 32274171
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Carrié, C
   Delzor, F
   Roure, S
   Dubuisson, V
   Petit, L
   Molimard, M
   Breilh, D
   Biais, M
AF Carrie, Cedric
   Delzor, Faustine
   Roure, Stephanie
   Dubuisson, Vincent
   Petit, Laurent
   Molimard, Mathieu
   Breilh, Dominique
   Biais, Matthieu
TI Population Pharmacokinetic Study of the Suitability of Standard Dosing
   Regimens of Amikacin in Critically III Patients with Open-Abdomen and
   Negative-Pressure Wound Therapy
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
DE open abdomen; negative-pressure therapy; amikacin; pharmacokinetics;
   Monte Carlo simulation; intensive care
ID CARE-UNIT PATIENTS; ILL PATIENTS; AMINOGLYCOSIDE THERAPY; NOSOCOMIAL
   PNEUMONIA; PEAK CONCENTRATION; REPLACEMENT; GENTAMICIN; PLASMA; IMPACT;
   SERUM
AB The aim was to assess the appropriateness of recommended regimens for empirical MIC coverage in critically ill patients with open-abdomen and negative-pressure therapy (OA/NPT). Over a 5-year period, every critically ill patient who received amikacin and who underwent therapeutic drug monitoring (TDM) while being treated by OA/NPT was retrospectively included. A population pharmacokinetic (PK) modeling was performed considering the effect of 10 covariates (age, sex, total body weight [TBW], adapted body weight [ABW], body surface area [BSA], modified sepsis-related organ failure assessment [SOFA] score, vasopressor use, creatinine clearance [CLCR], fluid balance, and amount of fluids collected by the NPT over the sampling day) in patients who underwent continuous renal replacement therapy (CRRT) or did not receive CRRT. Monte Carlo simulations were employed to determine the fractional target attainment (FTA) for the PK/pharmacodynamic [PD) targets (maximum concentration of drug [C-max]/MIC ratio of >= 8 and a ratio of the area under the concentration-time curve from 0 to 24 h [AUC(0-24)]/MIC of >= 75). Seventy critically ill patients treated by OA/NPT (contributing 179 concentration values) were included. Amikacin PK concentrations were best described by a two-compartment model with linear elimination and proportional residual error, with a CLCR and ABW as significant covariates for volume of distribution (V) and CLCR for CL. The reported V) in non-CRRT and CRRT patients was 35.8 and 40.2 liters, respectively. In Monte Carlo simulations, ABW-adjusted doses between 25 and 35 mg/kg were needed to reach an FTA of >85% for various renal functions. Despite an increased V and a wide inter-individual variability, desirable PK/PD targets may be achieved using an ABW-based loading dose of 25 to 30 mg/kg. When less susceptible pathogens are targeted, higher dosing regimens are probably needed in patients with augmented renal clearance (ARC). Further studies are needed to assess the effect of OA/NPT on the PK parameters of antimicrobial agents.
C1 [Carrie, Cedric; Roure, Stephanie; Petit, Laurent; Biais, Matthieu] CHU Bordeaux, Anesthesiol & Crit Care Dept, Bordeaux, France.
   [Delzor, Faustine; Breilh, Dominique] Univ Bordeaux, Pharmacokinet & PK PD Grp, INSERM 1034, Bordeaux, France.
   [Delzor, Faustine; Breilh, Dominique] CHU Bordeaux, Pharm & Clin Pharm Dept, Bordeaux, France.
   [Dubuisson, Vincent] CHU Bordeaux, Dept Vasc & Gen Surg, Bordeaux, France.
   [Molimard, Mathieu] CHU Bordeaux, Pharmacol & Toxicol Dept, Bordeaux, France.
   [Molimard, Mathieu; Biais, Matthieu] Univ Bordeaux Segalen, Bordeaux, France.
C3 CHU Bordeaux; Universite de Bordeaux; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite de Bordeaux; CHU Bordeaux;
   Universite de Bordeaux; Universite de Bordeaux; CHU Bordeaux; Universite
   de Bordeaux; CHU Bordeaux; Universite de Bordeaux
RP Carrié, C (通讯作者)，CHU Bordeaux, Anesthesiol & Crit Care Dept, Bordeaux, France.
EM cedric.carrie@chu-bordeaux.fr
RI molimard, mathieu/T-2762-2019; Petit, Laurent/M-3888-2019; BREILH,
   Dominique/AAH-8791-2021
OI BREILH, Dominique/0000-0002-3783-2797
CR Agence francaise de securite sanitaire des produits de sante, 2012, Med Mal Infect, V42, P301, DOI 10.1016/j.medmal.2011.07.007
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NR 35
TC 18
Z9 19
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD APR
PY 2020
VL 64
IS 4
AR e02098-19
DI 10.1128/AAC.02098-19
PG 10
WC Microbiology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Pharmacology & Pharmacy
GA KX3AB
UT WOS:000521752600035
PM 31964795
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Sexton, F
   Healy, D
   Keelan, S
   Alazzawi, M
   Naughton, P
AF Sexton, Fiona
   Healy, Donagh
   Keelan, Stephen
   Alazzawi, Mohammed
   Naughton, Peter
TI A systematic review and meta-analysis comparing the effectiveness of
   negative-pressure wound therapy to standard therapy in the prevention of
   complications after vascular surgery
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Review
DE Negative pressure wound therapy; Negative pressure dressing; Negative
   pressure wound dressing; Vascular surgery; Peripheral artery disease;
   Peripheral vascular disease
ID INCISION; TRIAL
AB Introduction: Negative pressure wound therapy (NPWT) dressings reduce wound complications in a variety of settings but it is unclear whether they reduce groin wound complications in closed incisions after vascular surgery. Therefore, we performed a systematic review and meta-analysis.
   Methods: Randomised controlled trials on the use of negative pressure wound dressings on closed groin incisions following vascular surgery were identified from an electronic search of abstract databases, conference proceedings and article reference lists. The primary outcome was surgical site infection (SSI) and secondary outcomes were seromas, readmissions within 30 days postoperatively, reoperations and length of stay.
   Results: 7 exploratory trials involving 935 incisions and an unclear number of patients were identified. 4 trials yielded primary outcome results that favoured NPWT. Meta-analysis found that NPWT dressings reduced SSIs (RR 0.47; 95%CI 0.31-0.70; 3 studies, 422 patients). No other meta-analyses could be performed.
   Conclusion: NPWT dressings are a promising intervention that may reduce the incidence of groin wound complications following vascular surgery. However, further large-scale well-designed studies are needed before NPWT dressings can become the standard of care.
C1 [Sexton, Fiona; Healy, Donagh; Keelan, Stephen; Alazzawi, Mohammed; Naughton, Peter] Beaumont Hosp, Dept Vasc Surg, Dublin, Ireland.
C3 Beaumont Hospital Dublin
RP Healy, D (通讯作者)，Beaumont Hosp, Dept Vasc Surg, Dublin, Ireland.
EM donaghhealy@rcsi.com
OI Healy, Donagh/0000-0002-4046-5457; Keelan, Stephen/0000-0002-3632-5128
CR [Anonymous], ANN SURG
   Banwell Paul, 2006, J Tissue Viability, V16, P16
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   Engelhardt M, 2018, INT WOUND J, V15, P327, DOI 10.1111/iwj.12848
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NR 17
TC 31
Z9 34
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD APR
PY 2020
VL 76
BP 94
EP 100
DI 10.1016/j.ijsu.2020.02.037
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KY5YP
UT WOS:000522649400033
PM 32142903
DA 2026-07-24
ER
PT J
AU Iacovelli, V
   Cipriani, C
   Sandri, M
   Filippone, R
   Ferracci, A
   Micali, S
   Rocco, B
   Puliatti, S
   Ferrarese, P
   Benedetto, G
   Minervini, A
   Cocci, A
   Pastore, AL
   Al Salhi, Y
   Antonelli, A
   Morena, T
   Volpe, A
   Poletti, F
   Celia, A
   Zeccolini, G
   Leonardo, C
   Proietti, F
   Agrò, EF
   Bove, P
AF Iacovelli, Valerio
   Cipriani, Chiara
   Sandri, Marco
   Filippone, Roberta
   Ferracci, Antonella
   Micali, Salvatore
   Rocco, Bernardo
   Puliatti, Stefano
   Ferrarese, Paolo
   Benedetto, Giuseppe
   Minervini, Andrea
   Cocci, Andrea
   Pastore, Antonio Luigi
   Al Salhi, Yazan
   Antonelli, Alessandro
   Morena, Tonino
   Volpe, Alessandro
   Poletti, Filippo
   Celia, Antonio
   Zeccolini, Guglielmo
   Leonardo, Costantino
   Proietti, Flavia
   Agro, Enrico Finazzi
   Bove, Pierluigi
TI The role of vacuum-assisted closure (VAC) therapy in the management of
   FOURNIER'S gangrene: a retrospective multi-institutional cohort study
SO WORLD JOURNAL OF UROLOGY
LA English
DT Article
DE Fournier's gangrene; Necrotizing fasciitis; Vacuum-assisted closure
   therapy; VAC; Wound therapy; Overall survival
ID HYPERBARIC-OXYGEN THERAPY
AB Purpose To explore the role of vacuum assisted closure (VAC) therapy versus conventional dressings in the Fournier's gangrene wound therapy. Patients and Methods This is a retrospective multi-institutional cohort study. Data of 92 patients from nine centers between 2007 and 2018 were retrospectively analyzed. After surgery, patient having a local or a disseminated FG were managed with VAC therapy or with conventional dressings. The 10-weeks wound closure cumulative rate and OS were analyzed. Results Of the 92 patients, 62 (67.4%) showed local and 30 (32.6%) a disseminated FG. After surgery, 19 patients (20.7%) with local and 14 (15.2%) with disseminated FG underwent to VAC therapy; 43 (46.7%) with local and 16 (17.4%) with disseminated FG were treated using conventional dressings. The multivariable logistic regression analysis demonstrated that the VAC in patients with disseminated FG led to a higher cumulative rate of wound closure than patients treated with no-VAC (OR = 6.5; 95% CI 1.1-37.4, p = 0.036). The Kaplan-Meier survival curves for the OS showed a significant difference between no-VAC patients with local and disseminated FG (OS rate at 90 days 0.90, 95% CI 0.71-0.97 vs 0.55, 95% CI 0.24-0.78, respectively; p = 0.039). Cox regression confirmed that no-VAC patients with disseminated FG showed the lowest OS (hazard ratio adjusted for sex and age HR = 3.4, 95% CI 1.1-10.4; p = 0.033). Conclusions In this large cohort study, VAC therapy in patients with disseminated FG may offer an advantage in terms of 10-weeks wound closure cumulative rate and OS at 90 days after initial surgery.
C1 [Iacovelli, Valerio; Cipriani, Chiara; Cocci, Andrea; Bove, Pierluigi] GVM Care & Res, Urol Unit, San Carlo Nancy Hosp, Via Aurelia 275, I-00100 Rome, Italy.
   [Iacovelli, Valerio; Filippone, Roberta; Agro, Enrico Finazzi] Univ Tor Vergata, Dept Surg Sci, Rome, Italy.
   [Sandri, Marco] Univ Brescia, Data Methods & Syst Stat Lab, Brescia, Italy.
   [Ferracci, Antonella] Policlin Tor Vergata Fdn, Dept Surg, Rome, Italy.
   [Micali, Salvatore; Rocco, Bernardo; Puliatti, Stefano] Univ Modena & Reggio Emilia, Dept Urol, Osped Policlin, Modena, Italy.
   [Micali, Salvatore; Rocco, Bernardo; Puliatti, Stefano] Univ Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense Modena, Modena, Italy.
   [Ferrarese, Paolo; Benedetto, Giuseppe] San Bortolo Hosp, Urol Unit, Vicenza, Italy.
   [Minervini, Andrea] Univ Florence, Careggi Hosp, Dept Urol, Florence, Italy.
   [Pastore, Antonio Luigi; Al Salhi, Yazan] ICOT Latina, Dept Urol, Latina, Italy.
   [Antonelli, Alessandro; Morena, Tonino] Univ Hosp Verona, Dept Surg Dent Paediat & Gynaecol, Urol Unit, Borgo Gen Hosp, Trento, Italy.
   [Volpe, Alessandro; Poletti, Filippo] Univ Piemonte Orientale, Maggiore Carita Hosp, Dept Urol, Novara, Italy.
   [Celia, Antonio; Zeccolini, Guglielmo] San Bassiano Hosp, Dept Urol, Bassano Del Grappa, Italy.
   [Leonardo, Costantino; Proietti, Flavia] Univ Roma La Sapienza, Dept Uroll, Rome, Italy.
C3 University of Rome Tor Vergata; University of Brescia; Universita di
   Modena e Reggio Emilia; Universita di Modena e Reggio Emilia; ULSS 8
   Berica; Ospedale San Bortolo di Vicenza; University of Florence; Azienda
   Ospedaliero Universitaria Careggi; University of Eastern Piedmont Amedeo
   Avogadro; ULSS 7 Pedemontana; Ospedale San Bassiano; Sapienza University
   Rome
RP Iacovelli, V (通讯作者)，GVM Care & Res, Urol Unit, San Carlo Nancy Hosp, Via Aurelia 275, I-00100 Rome, Italy.; Iacovelli, V (通讯作者)，Univ Tor Vergata, Dept Surg Sci, Rome, Italy.
EM valerio.iacovelli85@gmail.com
RI BOVE, PIERLUIGI/AAR-7019-2020; Cipriani, Chiara/AAC-3669-2022; Puliatti,
   Stefano/AAS-8339-2021; Minervini, Anea/AAB-8926-2019; FINAZZI AGRO,
   ENRICO/N-7969-2018; Proietti, Flavia/LSI-6771-2024; Cocci,
   Andrea/C-9735-2018; Iacovelli, Valerio/HJI-2832-2023; Sandri,
   Marco/L-2875-2013; antonelli, alessandro/AAU-2291-2020; PASTORE, ANTONIO
   LUIGI/F-1687-2011; Leonardo, Costantino/AAH-8609-2019; Micali,
   Salvatore/J-8179-2016
OI BOVE, PIERLUIGI/0000-0002-4788-2982; Cipriani,
   Chiara/0000-0001-7085-4966; Puliatti, Stefano/0000-0002-1597-9595;
   Minervini, Anea/0000-0001-5140-4628; FINAZZI AGRO,
   ENRICO/0000-0002-0308-8824; Proietti, Flavia/0000-0002-6478-8584; Cocci,
   Andrea/0000-0003-0138-6294; AL SALHI, YAZAN/0009-0005-1707-9485;
   Iacovelli, Valerio/0000-0001-5138-3177; Sandri,
   Marco/0000-0002-1422-5695; antonelli, alessandro/0000-0002-7455-8803;
   PASTORE, ANTONIO LUIGI/0000-0003-4293-9174; 
CR Assenza M, 2011, CLIN TER, V162, pE1
   Bonkat G, 2019, EUROPEAN ASS UROLOGY
   Capelli-Schellpfeffer M, 1999, J UROLOGY, V162, P647, DOI 10.1097/00005392-199909010-00002
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NR 27
TC 36
Z9 47
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0724-4983
EI 1433-8726
J9 WORLD J UROL
JI World J. Urol.
PD JAN
PY 2021
VL 39
IS 1
SI SI
BP 121
EP 128
DI 10.1007/s00345-020-03170-7
EA MAR 2020
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA QC0TY
UT WOS:000522711700001
PM 32236663
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Chen, X
   Mei, ZJ
   Shao, XS
AF Chen, Xiong
   Mei, Zujun
   Shao, Xianshu
TI The combination of a local injection of insulin and vacuum sealing
   drainage in patients with diabetic foot disease
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Insulin; vacuum sealing drainage; diabetic foot disease; granulation
   tissue; therapeutic effect
ID PLATELET-RICH PLASMA; CARE
AB Objective: To investigate the effect of a local injection of insulin in combination with vacuum sealing drainage (VSD) in patients with diabetic foot disease. Methods: A total of 98 patients with diabetic foot disease were randomly assigned to an observation group or a control group, with 49 patients in each group. The patients in the control group were assigned to VSD, and those in the observation group were given a local injection of insulin in addition to the treatment received by those in the control group. The clinical therapeutic effects of the regimens were compared between the two groups. The degree of granulation tissue regeneration was observed in both groups. The levels of insulin-like growth factor 1 (IGF1), serum inflammatory cytokines, oxidative stress, and the activities of lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH) in the granulation tissues were measured and compared between the two groups. Results: After treatment, the effective rates and the degree of granulation tissue regeneration were significantly higher in the observation group than they were in the control group (both P<0.05); the levels of IGF1, vascular endothelial growth factor (VEGF), total antioxidant capacity (TAC) of serum, catalase (CAT), and SDH were significantly elevated in both groups (all P<0.001), with significantly higher levels of the markers in the observation group (all P<0.001); in contrast, the levels of interleukin 6 (IL-6), malondialdehyde (MDA), and LDH in both groups were reduced considerably (all P<0.001), with substantially lower levels in the observation group (all P<0.001). Conclusion: Conventional VSD and a concomitant local injection of insulin improved the clinical manifestations, reduced the inflammatory reaction, and promoted the regeneration of granulation tissues in patients with diabetic foot disease. Thus, it is worthy of generalization in clinical practice.
C1 [Chen, Xiong] Jingzhou Cent Hosp, Dept Emergency Surg, Jingzhou, Hubei, Peoples R China.
   [Mei, Zujun] Jingzhou Cent Hosp, Dept Emergency, Jingzhou, Hubei, Peoples R China.
   [Shao, Xianshu] Jianghan Univ, Hosp Wuhan 6, Affiliated Hosp, Dept Western Med, 168 Hong Kong Rd, Wuhan 430015, Hubei, Peoples R China.
C3 Jianghan University
RP Shao, XS (通讯作者)，Jianghan Univ, Hosp Wuhan 6, Affiliated Hosp, Dept Western Med, 168 Hong Kong Rd, Wuhan 430015, Hubei, Peoples R China.
EM sha-oxianshu7sx6s@163.com
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NR 21
TC 0
Z9 0
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2020
VL 13
IS 3
BP 1905
EP 1912
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KY7GN
UT WOS:000522742100071
DA 2026-07-24
ER
PT J
AU Zhang, MS
   Sun, PY
   Liu, MZ
   Jiang, ZY
   Fu, ZH
   Min, DH
   Guo, GH
   Liao, XC
AF Zhang, Ming-Shi
   Sun, Peng-Yu
   Liu, Ming-Zhuo
   Jiang, Zheng-Ying
   Fu, Zhong-Hua
   Min, Ding-Hong
   Guo, Guang-Hua
   Liao, Xin-Cheng
TI A case report of a woman after childbirth with a dehisced abdominal
   wound as well as fat liquefaction and large skin necrosis
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE Dehisced wound; fat liquefaction; large skin necrosis; negative pressure
   wound therapy (NPWT); abdominal binder
ID MANAGEMENT
AB Recently high-frequency electric knife and abdominal binder are widely used in the abdominal operation in China. Nevertheless, with the high occurrence of the abdominal wound, we think that whether both these operations could be used or not. Here, we report the case of a 40-year-old female patient where negative pressure wound therapy (NPWT) was applied to her dehisced abdominal wound as well as fat liquefaction and large skin necrosis with pleasing results. The patient with high fever was referred to our department from her earlier hospital for 6 days after cesarean delivery. During the surgery, her earlier doctor used a high-frequency electric knife for convenient-using, and after the operation, the patient immediately used an abdominal binder for good shape. However, the abdominal surgical incision was opened at postoperative day 3, with fat liquefaction releasing large fatty acids along both abdominal sides with penetration under the abdominal binder. After admitted at postoperative day 6 with aggravating wound, surgery was considered because of no reduction in the size of the wound. A series of vacuum sealing drainage (VSD) or vacuum-assisted closure (VAC) as well as others, were operated. In the admitted 25th day, the wound was completely closed. NPWT is a practical and effective therapy for the treatment of numerous refractory and intractable wounds. Therefore, we suggest that the high-frequency electric knife and an abdominal binder should be avoided using an abdominal operation. This case is the first report of the use of NPWT over a dehisced abdominal wound with fat liquefaction and large skin necrosis on a postpartum patient in China.
C1 [Zhang, Ming-Shi; Sun, Peng-Yu] First Peoples Hosp Wenling, Dept Burns, Wenling 317500, Peoples R China.
   [Liu, Ming-Zhuo; Jiang, Zheng-Ying; Fu, Zhong-Hua; Min, Ding-Hong; Guo, Guang-Hua; Liao, Xin-Cheng] Nanchang Univ, Dept Burn, Affiliated Hosp 1, 17 Yong Wai St, Nanchang 330006, Jiangxi, Peoples R China.
C3 Nanchang University
RP Liao, XC (通讯作者)，Nanchang Univ, Dept Burn, Affiliated Hosp 1, 17 Yong Wai St, Nanchang 330006, Jiangxi, Peoples R China.
EM kendyliao2009@163.com
RI Zhang, Mingshi/JXN-0796-2024
FU Key research and development project of Jiangxi provincial science and
   technology department [20171ACG70004]
FX This work was supported by the Key research and development project of
   Jiangxi provincial science and technology department (20171ACG70004 to
   Guanghua Guo).
CR Asukai K, 2016, INT WOUND J, V13, P992, DOI 10.1111/iwj.12352
   Cheifetz O, 2010, PHYSIOTHER CAN, V62, P242, DOI 10.3138/physio.62.3.242
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NR 10
TC 4
Z9 4
U1 4
U2 21
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD MAR
PY 2020
VL 9
IS 2
BP 493
EP 496
DI 10.21037/apm.2020.03.15
PG 4
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA KY7VP
UT WOS:000522781300052
PM 32233635
OA gold
DA 2026-07-24
ER
PT J
AU Cagney, D
   Simmons, L
   O'Leary, DP
   Corrigan, M
   Kelly, L
   O'Sullivan, MJ
   Liew, A
   Redmond, HP
AF Cagney, David
   Simmons, Lydia
   O'Leary, Donal Peter
   Corrigan, Mark
   Kelly, Louise
   O'Sullivan, M. J.
   Liew, Aaron
   Redmond, Henry Paul
TI The Efficacy of Prophylactic Negative Pressure Wound Therapy for Closed
   Incisions in Breast Surgery: A Systematic Review and Meta-Analysis
SO WORLD JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT International Surgical Congress of the
   Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI)
CY MAY 07-09, 2019
CL Telford, ENGLAND
SP Assoc Surg Great Britain & Ireland
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; COST-EFFECTIVENESS
   ANALYSIS; CARE-ASSOCIATED INFECTIONS; FINANCIAL IMPACT; MANAGEMENT;
   MASTECTOMY; PREVENTION; STANDARD; DELAY
AB Background Negative pressure wound therapy (NPWT) is a promising advance in the management of closed surgical incisions. NPWT application induces several effects locally within the wound including reduced lateral tension and improving lymphatic drainage. As a result, NPWT may improve wound healing and reduce surgical site complications. We aim to evaluate the efficacy of prophylactic application of NPWT in preventing surgical site complications for closed incisions in breast surgery. Methods This systematic review was reported according to PRISMA guidelines. The protocol was published in PROSPERO (CRD42018114625). Medline, Embase, CINAHL and Cochrane Library databases were searched for studies which compare the efficacy of NPWT versus non-NPWT dressings for closed incisions in breast surgery. Specific outcomes of interest were total wound complications, surgical site infection (SSI), seroma, haematoma, wound dehiscence and necrosis. Results Seven studies (1500 breast incisions in 904 patients) met the inclusion criteria. NPWT was associated with a significantly lower rate of total wound complications [odds ratio (OR) 0.36; 95% CI 0.19-069; P = 0.002], SSI (OR 0.45; 95% CI 0.24-0.86; P = 0.015), seroma (OR 0.28; 95% CI 0.13-0.59; P = 0.001), wound dehiscence (OR 0.49; 95% CI 0.32-0.72; P < 0.001) and wound necrosis (OR 0.38; 95% CI 0.19-0.78; P = 0.008). There was no significant difference in haematoma rate (OR 0.8; 95% CI 0.19-3.2; P = 0.75). Statistically significant heterogeneity existed for total wound complications, but no other outcomes. Conclusion Compared with conventional non-NPWT dressings, prophylactic application of NPWT is associated with significantly fewer surgical site complications including SSI, seroma, wound dehiscence and wound necrosis for closed breast incisions.
C1 [Cagney, David; Simmons, Lydia; O'Leary, Donal Peter; Corrigan, Mark; Kelly, Louise; O'Sullivan, M. J.; Redmond, Henry Paul] Cork Univ Hosp, Dept Surg, Cork, Ireland.
   [Liew, Aaron] Natl Univ Ireland, Galway, Ireland.
   [Liew, Aaron] Portiuncula Univ Hosp, Galway, Ireland.
   [Corrigan, Mark; Kelly, Louise; O'Sullivan, M. J.] Cork Univ Hosp, Breast Canc Res Ctr, Cork, Ireland.
C3 University College Cork; Ollscoil na Gaillimhe-University of Galway;
   University College Cork
RP Cagney, D (通讯作者)，Cork Univ Hosp, Dept Surg, Cork, Ireland.
EM cagney.davej@gmail.com
OI Corrigan, Mark/0000-0002-9615-6450; Cagney, David/0000-0001-5505-3175
CR [Anonymous], 2016, Global Guidelines for the Prevention of Surgical Site Infection
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NR 43
TC 51
Z9 55
U1 1
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD MAY
PY 2020
VL 44
IS 5
BP 1526
EP 1537
DI 10.1007/s00268-019-05335-x
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA KY8OY
UT WOS:000522837000024
PM 31900568
DA 2026-07-24
ER
PT J
AU Aldana, PC
   Khachemoune, A
AF Aldana, Paola C.
   Khachemoune, Amor
TI Diabetic Foot Ulcers: Appraising Standard of Care and Reviewing New
   Trends in Management
SO AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
LA English
DT Review
ID HYPERBARIC-OXYGEN THERAPY; DOUBLE-BLIND; LIMB; AMPUTATION; TISSUE;
   BECAPLERMIN; PREVENTION; PATHWAYS; OUTCOMES
AB Diabetic foot ulcers (DFU) are one of the most common diabetes complications and are associated with significant morbidity and mortality. Current DFU standard of care (SOC) involves four principles: (1) pressure relief, (2) debridement, (3) infection management, and (4) revascularization when indicated. Despite the current SOC, many DFU persist, warranting a new approach for the management of these complex wounds. This review aims to summarize the current SOC as well as the latest trends in adjunctive therapies that may become the new SOC in DFU management. These include negative pressure wound therapy and hyperbaric oxygen therapy, bioengineered skin substitutes, growth factors, shockwave therapy, and several others. These novel therapies have shown significant DFU clinical improvement among subsets of DFU patients. However, much of the literature comes from smaller trials with inconsistent patient selection and outcomes measured, making it difficult to assess the true clinical benefit of these treatments. While novel therapies are promising for the interdisciplinary approach to DFU management, many still lack sufficient evidence, and their efficacy remains to be determined.
C1 [Aldana, Paola C.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
   [Khachemoune, Amor] Vet Affairs Med Ctr, Brooklyn, NY 11209 USA.
   [Khachemoune, Amor] SUNY Downstate, Dept Dermatol, 800 Poly Pl, Brooklyn, NY 11209 USA.
C3 University System of Maryland; University of Maryland Baltimore; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Khachemoune, A (通讯作者)，Vet Affairs Med Ctr, Brooklyn, NY 11209 USA.; Khachemoune, A (通讯作者)，SUNY Downstate, Dept Dermatol, 800 Poly Pl, Brooklyn, NY 11209 USA.
EM amorkh@gmail.com
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NR 55
TC 73
Z9 89
U1 3
U2 39
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-0561
EI 1179-1888
J9 AM J CLIN DERMATOL
JI Am. J. Clin. Dermatol.
PD APR
PY 2020
VL 21
IS 2
BP 255
EP 264
DI 10.1007/s40257-019-00495-x
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA KZ3JH
UT WOS:000523160800007
PM 31848923
DA 2026-07-24
ER
PT J
AU Jansaen, AHJ
   Wegdam, JA
   Reilingh, TSD
   Eskes, AM
   Vermeulen, H
AF Jansaen, Alexandra H. J.
   Wegdam, Johannes A.
   Reilingh, Tammo S. de Vries
   Eskes, Anne M.
   Vermeulen, Hester
TI Negative pressure wound therapy for patients with hard-to-heal wounds: a
   systematic review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE negative pressure wound therapy; patients' experiences; quality of life;
   systematic review; wounds and injuries
ID VACUUM-ASSISTED CLOSURE; SHARED DECISION-MAKING; EXPERIENCE; MANAGEMENT;
   CARE; NPWT
AB Objective: Despite the lack of evidence, negative pressure wound therapy (NPWT) is commonly used in patients with hard-to-heal wounds. In our medical centre, one third of patients with abdominal wounds infected postoperatively end this therapy prematurely due to negative experiences and prefer standard wound care. This study was designed to explore the effects of NPWT on quality of life (QoL).
   Method: A search from 2000 to 2019 in eight databases was performed to identify qualitative studies of patients treated with NPWT. Studies were selected by two independent reviewers, who appraised the methodological quality, extracted and structured the data and performed content analysis.
   Results: A total of five qualitative studies with good methodological quality, incorporating 51 individual patients, were included. After content analysis, four major themes emerged: reduced freedom of movement caused by an electric device; decreased self-esteem; increased social and professional dependency; and gaining self-control.
   Conclusion: NPWT has major effects on the physical, psychological and social domains of QoL. Knowledge of these effects may lead to improved treatment decisions for patients with hard-to-heal wounds regarding use of NPWT or standard wound care.
   Declaration of interest: The authors have no conflicts of interest.
C1 [Jansaen, Alexandra H. J.; Wegdam, Johannes A.; Reilingh, Tammo S. de Vries] Elkerliek Hosp, Dept Surg, Helmond, Netherlands.
   [Eskes, Anne M.] Univ Amsterdam, Dept Surg, Amsterdam UMC, Amsterdam, Netherlands.
   [Eskes, Anne M.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia.
   [Eskes, Anne M.] Griffith Univ, Sch Nursing & Midwifery, Gold Coast, Australia.
   [Vermeulen, Hester] Radboud Univ Nijmegen, Sci Inst Qual Healthcare IQ Healthcare, Nijmegen, Netherlands.
C3 University of Amsterdam; Griffith University; Menzies Health Institute
   Queensland; Griffith University; Radboud University Nijmegen
RP Jansaen, AHJ (通讯作者)，Elkerliek Hosp, Dept Surg, Helmond, Netherlands.
EM sjanssen@elkerliek.nl
RI Eskes, Anne/HKV-3276-2023; Vermeulen, Hester/P-5739-2016
OI Janssen, Alexana/0000-0003-1816-0814; Eskes, Anne
   Maria/0000-0003-1605-0195
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NR 34
TC 12
Z9 15
U1 0
U2 11
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2020
VL 29
IS 4
BP 206
EP 212
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA LA5YT
UT WOS:000524023900009
PM 32281512
DA 2026-07-24
ER
PT J
AU Latouche, V
   Devillers, H
AF Latouche, Valerie
   Devillers, Herve
TI Benefits of negative pressure wound therapy with instillation in the
   treatment of hard-to-heal wounds: a case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE complex wounds; diabetes; dissecting haematoma; injuries; negative
   pressure wound therapy with instillation; postoperative wounds; pressure
   ulcers; trauma wounds; wounds
ID COMPLEX WOUNDS; SALINE; OUTCOMES
AB Objective: Impaired wound healing can lead to hard-to-heal wounds, which impact on patients, clinicians and healthcare systems. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) was developed to manage wounds through early-stage cleansing. This study describes the use of NPWTi-d to help manage hard-to-heal wounds in patients with risk factors for impaired wound healing.
   Method: In this case series, patients were treated between October 2015 and March 2018 at a community hospital in western France. Normal saline solution was instilled into wounds with a dwell time of 10 minutes, followed by the application of negative pressure at -75 mmHg to -125 mmHg for 2-3 hours. If needed, patients were given appropriate oral or intravenous antibiotic treatment in conjunction with NPWTi-d and subsequent wound therapies.
   Results: A total of 15 patients participated in the study. Mean age was 81 +/- 13 years, and 12 (80%) patients were malnourished with blood albumin levels of 30.1 +/- 5.7g/l, and 12 (80%) patients were given antibiotic therapy. The mean duration of NPWTi-d was 19.4 +/- 20.8 days, with a mean number of dressing changes of 6.6 +/- 6.8; the duration of NPWTi-d and the number of dressing changes for pressure ulcers was three times that of the other wound types. The mean cost of NPWTi-d in this study was (sic)1643.40 +/-(sic)1709.13. Overall, NPWTi-d provided early-stage wound cleansing and helped achieve adequate granulation tissue formation and progression to the next phase of wound healing.
   Conclusion: In these cases, NPWTi-d was a beneficial and effective method of treating hard-to-heal wounds that were resistant to traditional treatments, yielding favourable clinical outcomes. Declaration of interest: The authors have no conflicts of interest to declare.
C1 [Latouche, Valerie; Devillers, Herve] Hosp Ctr Intercommunal Redon Carentoir, Dept Geriatr & Phys Therapy & Rehabil, Redon, France.
RP Latouche, V (通讯作者)，Hosp Ctr Intercommunal Redon Carentoir, Dept Geriatr & Phys Therapy & Rehabil, Redon, France.
EM infirmiere.plaiecica@ch-redon.fr
CR Anghel EL, 2016, INT WOUND J, V13, P19, DOI 10.1111/iwj.12664
   Belch JJF, 2003, ARCH INTERN MED, V163, P884, DOI 10.1001/archinte.163.8.884
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   Wolvos T, 2015, J WOUND CARE, V24, P15, DOI 10.12968/jowc.2015.24.Sup4b.15
NR 24
TC 5
Z9 5
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2020
VL 29
IS 4
BP 248
EP 253
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA LA5YT
UT WOS:000524023900013
PM 32281508
DA 2026-07-24
ER
PT J
AU Hasselmann, J
   Björk, J
   Svensson-Björk, R
   Acosta, S
AF Hasselmann, Julien
   Bjork, Jonas
   Svensson-Bjork, Robert
   Acosta, Stefan
TI Inguinal Vascular Surgical Wound Protection by Incisional Negative
   Pressure Wound Therapy A Randomized Controlled Trial-INVIPS Trial
SO ANNALS OF SURGERY
LA English
DT Article
DE negative pressure wound therapy; NPWT; surgical site infection; SSI;
   vascular surgery; groin
ID SITE INFECTIONS; MANAGEMENT; PREVENTION
AB Objective: A randomized controlled trial (RCT) was undertaken to determine the effect of negative pressure wound therapy (NPWT) on closed incisions after inguinal vascular surgery regarding surgical site infections (SSIs) and other wound complications. Background: SSIs are a major concern in open vascular procedures involving the inguinal region. Prophylactic NPWT on closed incisions has shown promising results, but the quality of evidence can be debated. This study aims to objectively evaluate whether NPWT on sutured inguinal incisions after elective vascular surgery can decrease the incidence of surgical site complications. Methods: One hundred thirty-nine patients undergoing elective open vascular surgery with inguinal incisions received either NPWT or a standard dressing. Patients with bilateral incisions randomly received a dressing on one incision and the opposite dressing on the other. The primary endpoints were SSI or other wound complications at 3 months, assessed by wound care experts blinded to the treatment arm and using objective wound assessment criteria (ASEPSIS-score). Statistical analysis was performed on an intention-to-treat basis and obtained P values from analyses in the uni- and bilateral groups were combined to an overall P value using Fisher's method for combining P values. Results: The incidence of SSI was reduced in the NPWT group compared with the control group [11.9% vs 29.5% in the unilateral group (n = 120), 5.3% vs 26.3% in the bilateral group (n = 19), respectively; combined P = 0.02]. No differences regarding other surgical site complications were observed between the groups. Conclusion: NPWT on closed inguinal vascular surgical incisions in elective patients reduces the incidence of SSI.
C1 [Hasselmann, Julien; Svensson-Bjork, Robert; Acosta, Stefan] Skane Univ Hosp, Vasc Ctr, Malmo, Sweden.
   [Hasselmann, Julien; Svensson-Bjork, Robert; Acosta, Stefan] Lund Univ, Dept Clin Sci, Lund, Sweden.
   [Bjork, Jonas] Lund Univ, Div Occupat & Environm Med, Lund, Sweden.
   [Bjork, Jonas] Lund Univ Hosp, Clin Studies Sweden, Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Lund
   University; Lund University; Skane University Hospital
RP Hasselmann, J (通讯作者)，Lund Univ, Dept Clin Sci, Ruth Lundskogs Gata 10, S-20502 Malmo, Sweden.
EM JNHasselmann@gmail.com
RI Hasselmann, Julien/C-1586-2015; Acosta, Stefan/JAX-3225-2023; Björk,
   Jonas/AFS-4819-2022; Hasselmann, Julien/C-1586-2015
OI Acosta, Stefan/0000-0002-3225-0798; Björk, Jonas/0000-0003-1883-2000;
   Hasselmann, Julien/0000-0003-4453-0292; Svensson-Björk,
   Robert/0000-0003-1907-9022
FU Skane County (Region Skane); Skane University Hospital; Hulda Almroth
   foundation; Smith and Nephew
FX The trial has been funded by public Swedish funds stemming from Skane
   County (Region Skane), the Skane University Hospital, and the Hulda
   Almroth foundation since 2015 adding up to a total of 2.81 million SEK
   (about 311,000 USD). In addition, the research group received an
   unrestricted unconditional research grant of 15,550 USD and a donation
   of 100 PICO dressing kits from Smith and Nephew in 2013.
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
   Berríos SI, 2017, JAMA SURG, V152, P784, DOI 10.1001/jamasurg.2017.0904
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   Kilpadi DV, 2011, WOUND REPAIR REGEN, V19, P588, DOI 10.1111/j.1524-475X.2011.00714.x
   Kwon J, 2018, J VASC SURG, V68, P1744, DOI 10.1016/j.jvs.2018.05.224
   Lee K, 2017, J VASC SURG, V66, P1814, DOI 10.1016/j.jvs.2017.06.084
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   National Healthcare Safety Network Centers for Disease Control and Prevention, 2017, Surgical site infection (SSI) event
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   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
   WILSON APR, 1986, LANCET, V1, P311
NR 20
TC 44
Z9 45
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JAN
PY 2020
VL 271
IS 1
BP 48
EP 53
DI 10.1097/SLA.0000000000003364
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LC0JF
UT WOS:000525016300014
PM 31283565
DA 2026-07-24
ER
PT J
AU Kuper, TM
   Murphy, PB
   Kaur, B
   Ott, MC
AF Kuper, Tanya M.
   Murphy, Patrick B.
   Kaur, Bandeep
   Ott, Michael C.
TI Prophylactic Negative Pressure Wound Therapy for Closed Laparotomy
   Incisions A Meta-analysis of Randomized Controlled Trials
SO ANNALS OF SURGERY
LA English
DT Article
DE general surgery; negative pressure wound therapy; surgical site
   infections
ID SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   PREVENTION; SURGERY; AGREEMENT
AB Objective: The aim of this study was to determine whether negative pressure wound therapy (NPWT) applied to primarily closed incisions decreases surgical site infections (SSIs) following open abdominal surgery. Background: SSIs are a common cause of morbidity following open abdominal surgery. Prophylactic NPWT has shown promise for SSI reduction. However, the results of randomized controlled trials (RCTs) conducted among patients undergoing laparotomy have been inconsistent. Methods: We performed a meta-analysis of English language RCTs comparing the use of prophylactic NPWT to standard dressings on primarily closed laparotomy incisions following open abdominal surgery. Medline, EMBASE, Cochrane Library, and CINAHL databases were searched from inception to December 31(st), 2018, for relevant studies. A random-effects model was used for statistical analysis. Results: Five RCTs totaling 792 patients were included in our meta-analysis after application of our exclusion and inclusion criteria. There was no significant difference in the risk of SSIs identified among those patients who had NPWT compared to standard dressings; relative risk (RR) 0.56 (95% confidence interval 0.30-1.03, P = 0.064). There was significant statistical heterogeneity across studies (I-2 = 67.4%; P = 0.015). Conclusion: The adoption of NPWT for routine SSI prophylaxis following laparotomy is currently not supported and should be used primarily in the context of a clinical trial.
C1 [Kuper, Tanya M.; Murphy, Patrick B.; Ott, Michael C.] Western Univ, Schulich Sch Med & Dent, Div Gen Surg, Dept Surg, London, ON, Canada.
   [Kaur, Bandeep] Western Univ, Schulich Sch Med & Dent, London, ON, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario)
RP Kuper, TM (通讯作者)，Western Univ, Schulich Sch Med & Dent, Div Gen Surg, Dept Surg, London, ON, Canada.
EM kuper.tanya@gmail.com
RI ; Murphy, Patrick/T-5337-2019
OI Ott, Michael/0000-0002-0816-7089; 
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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NR 32
TC 48
Z9 51
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JAN
PY 2020
VL 271
IS 1
BP 67
EP 74
DI 10.1097/SLA.0000000000003435
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LC0JF
UT WOS:000525016300016
PM 31860549
DA 2026-07-24
ER
PT J
AU Su, F
   Cheng, L
   Tong, Q
AF Su, Feng
   Cheng, Liu
   Tong, Qiao
TI Effectiveness of tumescent solution combined with negative pressure
   wound therapy in traditional high ligation and stripping of the great
   saphenous vein
SO MEDICINE
LA English
DT Article
DE ecchymosis; high ligation and stripping of great saphenous vein; pain;
   tumescence solution
ID ENDOVENOUS LASER-ABLATION; FOAM SCLEROTHERAPY; VARICOSE-VEIN;
   MASTECTOMY; ANESTHESIA; SAFE
AB Traditional high ligation and stripping (THLS) is a routine operation for varicose veins. However, THLS is accompanied with postoperative subcutaneous ecchymosis and pain. In this current study, we aimed to explore the effect of tumescence solution (TS) combined with negative pressure wound therapy (NPWT) on the relief of subcutaneous ecchymosis and pain after THLS of great saphenous vein. A total of 180 patients receiving THLS were enrolled in group A, and 120 patients undergoing THLS and TS combined with NPWT were assigned into group B. The occurrences of subcutaneous ecchymosis and pain were recorded. Moreover, the total area of subcutaneous ecchymosis was estimated by the grid method. Visual analogue scale (VAS) score was used to assess the pain level of both groups. Preoperative characteristics were not significantly different between 2 groups. Postoperative ecchymosis occurred in 112 cases (62.2%) of group A and 41 cases (34.2%) of group B. The area of ecchymosis in group A (66.6 +/- 44.5) cm(2) was larger than that in group B (25.2 +/- 19.9) cm(2). The number of patients without obvious pain in group A (57, 31.7%) was significantly less than that in group B (77, 64.2%) after operation. In addition, VAS score in group A (3.1 +/- 2.6) was higher than that in group B (2.2 +/- 1.9). In conclusion, the application of TS combined with NPWT in THLS can not only alleviate subcutaneous ecchymosis and pain, but also prevent the occurrence of subcutaneous ecchymosis and pain after operation. Therefore, it is conducive to postoperative recovery and is suitable for clinical application.
C1 [Su, Feng] Nanjing Med Univ, Dept Vasc Surg, Xuzhou Sch Clin Med, Xuzhou, Jiangsu, Peoples R China.
   [Su, Feng] Xu Zhou Cent Hosp, Dept Vasc Surg, Xuzhou, Jiangsu, Peoples R China.
   [Cheng, Liu; Tong, Qiao] Nanjing Med Univ, Drum Tower Clin Med Coll, Dept Vasc Surg, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China.
   [Cheng, Liu; Tong, Qiao] Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Vasc Surg, Nanjing, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Nanjing
   University
RP Tong, Q (通讯作者)，Nanjing Med Univ, Drum Tower Clin Med Coll, Dept Vasc Surg, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China.
EM qiaotong31@163.com
CR Al Shakarchi J, 2018, J VASC SURG-VENOUS L, V6, P220, DOI 10.1016/j.jvsv.2017.08.013
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NR 32
TC 3
Z9 3
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAR
PY 2020
VL 99
IS 11
AR 19040
DI 10.1097/MD.0000000000019040
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LC2ZQ
UT WOS:000525195500008
PM 32176031
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rapp, SJ
   Dershem, V
   Zhang, X
   Schutte, SC
   Chariker, ME
AF Rapp, Scott J.
   Dershem, Victoria
   Zhang, Xiang
   Schutte, Stacey C.
   Chariker, Mark E.
TI Varying Negative Pressure Wound Therapy Acute Effects on Human
   Split-Thickness Autografts
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS; GLUE
AB Over 6.5 million people in the United States suffer from traumatic, burn, acute, and chronic wounds yearly. When reconstruction is required, split and full-thickness autografts are a first line of treatment intervention. Negative pressure wound therapy (NPWT) is gaining traction as an adjunct modality to improve graft survival, yet the specifics on what settings to apply topically over the graft is unsubstantiated and associated with morbidities. This study was performed in an effort to understand initial changes in wound and graft healing with a long-term goal of surface pressure optimization. Excess skin from elective procedures from six human subjects was trimmed to 0.012 inch in order represent a split-thickness autografts. These grafts were treated continuously with either -75 mm Hg (n = 4), -125 mm Hg (n = 4), or no pressure (n = 4) for 3 hours. Six skin grafts were treated with no sponge or pressure control (n = 6). RNAseq was performed on all treatment groups and compared with no pressure control. Significant gene expression changes with a subset focusing on inflammatory, cellular/extracellular matrix proliferation and angiogenic mediators and having greater than 2-fold were confirmed with immunohistochemistry staining. There are 95 significant gene transcription differences among all treatment groups. NPWT leads to significantly increased gene expression of FGFR1, ET-1, and 22 Keratin proteins. Between -75 and -125 mm Hg groups, there are 19 significant gene changes. Proinflammatory genes S100A8 and Tenacin C (TNC) demonstrate an 8.8- and 9.1-fold change, respectively, and is upregulated in -125 mm Hg group and downregulated in -75 mm Hg group. Fibrinogen genes fibrinogen gamma chain and fibrinogen alpha chain had respective log2-fold changes of -7.9 and -7.4 change between treatment groups and were downregulated in -125 mm Hg group and upregulated in -75 mm Hg group. There are varying effects of surface pressures on human split-thickness autografts during the imbibition time period. NPWT may improve cellular migration, proliferation, and angiogenesis over controls. Human skin grafts respond differently to -125 and -75 mm Hg within 3 hours of NPWT treatment. The results suggest -75 mm Hg leads to less inflammation and increased fibrinogen production compared with the -125 mm Hg group, at least initially. Reducing "time to heal" with NPWT is critical to successful outcomes and quality of life within young patients who often experience pain/discomfort when treated at the current standard pump settings. The results from this study and continued investigation may quickly translate to the clinical setting by finding the ideal pressure setting utilized in an effort to reduce NPWT length of treatment, improve patient comfort, satisfaction, and psychosocial well-being.
C1 [Rapp, Scott J.; Dershem, Victoria; Schutte, Stacey C.] Shriners Hosp Children, Dept Res, Div Pediat Plast Surg, Cincinnati, OH 45229 USA.
   [Rapp, Scott J.; Chariker, Mark E.] Norton Childrens Hosp, Dept Surg, Div Plast Surg, Louisville, KY USA.
   [Zhang, Xiang; Schutte, Stacey C.] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH USA.
   [Rapp, Scott J.; Chariker, Mark E.] Kentucky Ctr Cosmet & Reconstruct Surg, Louisville, KY USA.
C3 University System of Ohio; University of Cincinnati
RP Rapp, SJ (通讯作者)，Shriners Hosp Children, Div Plast Surg, 3229 Burnet Ave, Cincinnati, OH 45229 USA.
EM srapp@shinenet.org
RI Schutte, Stacey/L-9039-2019
OI Schutte, Stacey/0000-0002-8092-5067
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NR 30
TC 21
Z9 27
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2020
VL 41
IS 1
BP 104
EP 112
DI 10.1093/jbcr/irz122
PG 9
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA LD2DZ
UT WOS:000525842600013
PM 31420676
DA 2026-07-24
ER
PT J
AU Chen, Y
   Kuang, XC
   Zhou, J
   Zhen, PX
   Zeng, ZS
   Lin, ZX
   Gao, W
   He, LH
   Ding, Y
   Liu, GW
   Qiu, SH
   Qin, A
   Lu, W
   Lao, S
   Zhao, JM
   Hua, QK
AF Chen, Yan
   Kuang, Xiaocong
   Zhou, Jia
   Zhen, Puxiang
   Zeng, Zisan
   Lin, Zhenxun
   Gao, Wei
   He, Lihuan
   Ding, Yi
   Liu, Guangwei
   Qiu, Shaohua
   Qin, An
   Lu, William
   Lao, Shan
   Zhao, Jinmin
   Hua, Qikai
TI Proximal Tibial Cortex Transverse Distraction Facilitating Healing and
   Limb Salvage in Severe and Recalcitrant Diabetic Foot Ulcers
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
ID PERIPHERAL ARTERY-DISEASE; IWGDF GUIDANCE; BLOOD-FLOW; RISK; MANAGEMENT;
   AMPUTATION; BONE; MICROCIRCULATION; INTERVENTIONS; EPIDEMIOLOGY
AB Background The management of severe and recalcitrant diabetic foot ulcers is challenging. Distraction osteogenesis is accompanied by vascularization and regeneration of the surrounding tissues. Longitudinal distraction of the proximal tibia stimulates increased and prolonged blood flow to the distal tibia. However, the effects of transverse distraction of the proximal tibia cortex on severe and recalcitrant diabetic foot ulcers are largely unknown. Questions/purposes (1) Does tibial cortex transverse distraction increase healing and decrease major amputation and recurrence of severe and recalcitrant diabetic foot ulcers compared with routine management (which generally included debridement, revascularization, negative pressure wound therapy, local or free flaps, or skin grafts as indicated)? (2) Does neovascularization and perfusion increase at the foot after the procedure? (3) What are the complications of tibial cortex transverse distraction in patients with severe and recalcitrant diabetic foot ulcers? Methods Between July 2014 and March 2017, we treated 136 patients with diabetes mellitus and University of Texas Grade 2B to 3D ulcers (wound penetrating to the tendon, capsule, bone, or joint with infection and/or ischemia). The patients had failed to respond to treatment for at least 6 months, and their ulcers had a mean +/- SD area of 44 cm(2) +/- 10 cm(2). All 136 patients underwent tibial cortex transverse distraction (partial corticotomy of the upper tibia, which was in normal condition, followed by 4 weeks of transverse distraction medially then laterally). We compared these patients with the last 137 consecutive patients we treated with standard surgical treatment, consisting of debridement, revascularization, local or free flap or skin equivalent, or graft reconstruction along with negative-pressure wound therapy between May 2011 and June 2013; there was a 1-year period during which both treatments were in use, and we did not include patients whose procedures were performed during this time in either group. Patients in both groups received standard off-loading and wound care. The patients lost to follow-up by 2 years (0.7% of the treatment group [one of 137] and 1.4% of the control group [two of 139]; p = 0.57) were excluded. The patients in the treatment and control groups had a mean age of 61 years and 60 years, respectively, and they were predominantly men in both groups (70% [95 of 136] versus 64% [88 of 137]; p = 0.32). There were no differences with respect to parameters associated with the likelihood of ulcer healing, such as diabetes and ulcer duration, ulcer grades and area, smoking, and arterial status. We compared the groups with respect to ulcer healing (complete epithelialization without discharge, maintained for at least 2 weeks, which was determined by an assessor not involved with clinical care) in a 2-year follow-up, the proportion of ulcers that healed by 6 months, major amputation, recurrence, and complications in the 2-year follow-up. Foot arterial status and perfusion were assessed in the tibial cortex transverse distraction group using CT angiography and perfusion imaging. Results The tibial cortex transverse distraction group had a higher proportion of ulcers that healed in the 2-year follow-up than the control group (96% [131 of 136] versus 68% [98 of 137]; odds ratio 10.40 [95% confidence interval 3.96 to 27.43]; p < 0.001).
   By 6 months, a higher proportion of ulcers healed in the tibia cortex transverse distraction group than the control group (93% [126 of 136] versus 41% [56 of 137]; OR 18.2 [95% CI 8.80 to 37.
   76]; p < 0.001). Lower proportions of patients in the tibia cortex transverse distraction group underwent major amputation (2.9% [four of 136] versus 23% [31 of 137], OR 0.10 [95% CI 0.04 to 0.30]; p < 0.001) or had recurrences 2.9% (4 of 136) versus 17% (23 of 137), OR 0.20 [95% CI 0.05 to 0.45]; p < 0.001) than the control group in 2-year follow-up. In the feet of the patients in the tibial cortex transverse distraction group, there was a higher density of small vessels (19 +/- 2.1/mm(2) versus 9 +/- 1.9/mm(2); mean difference 10/mm(2); p = 0.010), higher blood flow (24 +/- 5 mL/100 g/min versus 8 +/- 2.4 mL/100 g/min, mean difference 16 mL/100 g/min; p = 0.004) and blood volume (2.5 +/- 0.29 mL/100 g versus 1.3 +/- 0.33 mL/100 g, mean difference 1.2 mL/100 g; p = 0.03) 12 weeks postoperatively than preoperatively. Complications included closed fractures at the corticotomy site (in 1.5% of patients; two of 136), which were treated with closed reduction and healed, as well as pin-site infections (in 2.2% of patients; three of 136), which were treated with dressing changes and they resolved without osteomyelitis. Conclusions Proximal tibial cortex transverse distraction substantially facilitated healing and limb salvage and decreased the recurrence of severe and recalcitrant diabetic foot ulcers. The surgical techniques were relatively straightforward although the treatment was unorthodox, and the complications were few and minor. These findings suggest that tibial cortex transverse distraction is an effective procedure to treat severe and recalcitrant diabetic foot ulcers compared with standard surgical therapy. Randomized controlled trials are required to confirm these findings.
C1 [Chen, Yan; Zhen, Puxiang; Lin, Zhenxun; Gao, Wei; He, Lihuan; Ding, Yi; Liu, Guangwei; Lao, Shan; Zhao, Jinmin; Hua, Qikai] Guangxi Med Univ, Dept Bone & Joint Surg, Affiliated Hosp 1, 6 Shuangyong Rd, Nanning 530021, Peoples R China.
   [Kuang, Xiaocong] Guangxi Med Univ, Preclin Sch, Dept Physiopathol, Nanning, Peoples R China.
   [Zhou, Jia] Guangxi Med Univ, Affiliated Hosp 1, Dept Endocrinol, Nanning, Peoples R China.
   [Zeng, Zisan; Qiu, Shaohua] Shanxi Med Univ, Affiliated Hosp 1, Dept Radiol, Taiyuan, Peoples R China.
   [Qin, An] Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Orthopaed, Shanghai Key Lab Orthopaed Implants,Sch Med, Shanghai, Peoples R China.
   [Lu, William] Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University; Shanxi Medical University; Shanghai Jiao Tong University;
   University of Hong Kong
RP Hua, QK (通讯作者)，Guangxi Med Univ, Dept Bone & Joint Surg, Affiliated Hosp 1, 6 Shuangyong Rd, Nanning 530021, Peoples R China.
EM hqk100@yeah.net
RI zhao, jin/LBH-0351-2024; Chen, Yan/MDS-5942-2025; /T-9081-2019
FU National Natural Science Foundation of China [81601930]; Natural Science
   Foundation of Guangxi [2017GXNSFAA198318, 2016GXNSFBA380007,
   2017GXNSFAA198293]; Postdoctoral Science Foundation of China [223363];
   Science Foundation for the Excellent Young Scholars of Guangxi
   Collaborative Innovation Center for Biomedicine [GCICB-TC-2017003]
FX The institution of the authors (YC, QH) has received, during the study
   period, funding from the National Natural Science Foundation of China
   (81601930), Natural Science Foundation of Guangxi (2017GXNSFAA198318,
   2016GXNSFBA380007, and 2017GXNSFAA198293), and Postdoctoral Science
   Foundation of China (223363), Science Foundation for the Excellent Young
   Scholars of Guangxi Collaborative Innovation Center for Biomedicine
   (GCICB-TC-2017003).
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NR 52
TC 79
Z9 124
U1 4
U2 57
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-921X
EI 1528-1132
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD APR
PY 2020
VL 478
IS 4
BP 836
EP 851
DI 10.1097/CORR.0000000000001075
PG 16
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA LD7WN
UT WOS:000526239700028
PM 31794478
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Rys, P
   Borys, S
   Hohendorff, J
   Zapala, A
   Witek, P
   Monica, M
   Frankfurter, C
   Ludwig-Slomczynska, A
   Kiec-Wilk, B
   Malecki, MT
AF Rys, Przemyslaw
   Borys, Sebastian
   Hohendorff, Jerzy
   Zapala, Aleksandra
   Witek, Przemyslaw
   Monica, Magdalena
   Frankfurter, Claudia
   Ludwig-Slomczynska, Agnieszka
   Kiec-Wilk, Beata
   Malecki, Maciej T.
TI NPWT in diabetic foot wounds-a systematic review and meta-analysis of
   observational studies
SO ENDOCRINE
LA English
DT Review
DE Negative-pressure wound therapy; Diabetic foot syndrome; Wound healing
ID VACUUM-ASSISTED CLOSURE; LIMB SALVAGE; THERAPY; ULCERS; MULTICENTER;
   EXPERIENCE; AMPUTATION
AB Purpose Negative-pressure wound therapy (NPWT) is an adjunct modality in diabetic foot ulcerations (DFUs). Randomized controlled trials (RCTs) have shown its advantage over standard approaches; however, data from observational studies remain scarce.We performed a systematic review of observational non-RCTs evaluating NPWT efficacy and safety in patients with DFU. Methods Electronic databases were searched for observational studies involving NPWT. The results of single-arm studies were presented as percentages of patients with the outcome of interest. A meta-analysis of comparative studies provided point estimates of outcomes. Continuous outcomes were reported as either weighted or standardized mean differences and dichotomous data as relative risks (RR). Results The search identified 16 relevant observational studies, 12 single-arm, and 4 comparative, reporting on a total of 18,449 patients with DFU, of whom 1882 were managed with NPWT. In the NPWT-treated patients, ulcers were larger (average size range 6.6-27.9 cm(2)), as compared with controls (<= 3 cm(2)). The pooled results showed healing and major amputation in 51% and 5% of NPWT patients, respectively. The meta-analysis of comparative studies revealed lower risk of major amputation [RR = 0.23 (0.07; 0.80)] in NPWT-treated patients. The pooled results for healing rate and risk of any amputation were inconclusive due to large between-study heterogeneity. Overall, 6 deaths out of 158 patients were reported, none of them related to NPWT. Serious adverse events occurred in 6% of patients on NPWT. Conclusions This systematic review of observational studies provided supportive evidence that NWPT is an efficient and safe adjunct treatment in the management of DFUs.
C1 [Rys, Przemyslaw; Zapala, Aleksandra; Monica, Magdalena] HTA Consulting, Krakow, Poland.
   [Borys, Sebastian; Hohendorff, Jerzy; Witek, Przemyslaw; Kiec-Wilk, Beata; Malecki, Maciej T.] Jagiellonian Univ Med Coll, Dept Metab Dis, Krakow, Poland.
   [Borys, Sebastian; Hohendorff, Jerzy; Witek, Przemyslaw; Kiec-Wilk, Beata; Malecki, Maciej T.] Univ Hosp Krakow, Dept Metab Dis, Krakow, Poland.
   [Frankfurter, Claudia] Univ Toronto, Fac Med, Toronto, ON, Canada.
   [Ludwig-Slomczynska, Agnieszka] Jagiellonian Univ Med Coll, Ctr Med Genom OMICRON, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   University of Toronto; Jagiellonian University; Collegium Medicum
   Jagiellonian University
RP Malecki, MT (通讯作者)，Jagiellonian Univ Med Coll, Dept Metab Dis, Krakow, Poland.; Malecki, MT (通讯作者)，Univ Hosp Krakow, Dept Metab Dis, Krakow, Poland.
EM maciej.malecki@uj.edu.pl
RI Hohendorff, Jerzy/U-1857-2018; Witek, Przemysław/AGX-0421-2022; Monica,
   Magdalena/JXY-4078-2024
OI Hohendorff, Jerzy/0000-0003-1153-8669; Ludwig-Słomczyńska, Agnieszka
   H/0000-0002-0548-4767; Monica, Magdalena/0000-0001-5089-5349
CR [Anonymous], 2019, 2019 WORKING GROUP W
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NR 34
TC 14
Z9 21
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD APR
PY 2020
VL 68
IS 1
BP 44
EP 55
DI 10.1007/s12020-019-02164-9
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LE6CS
UT WOS:000526811200006
PM 31919770
OA Green Submitted
DA 2026-07-24
ER
PT J
AU McCaughan, D
   Sheard, L
   Cullum, N
   Dumville, J
   Chetter, I
AF McCaughan, Dorothy
   Sheard, Laura
   Cullum, Nicky
   Dumville, Jo
   Chetter, Ian
TI Nurses' and surgeons' views and experiences of surgical wounds healing
   by secondary intention: A qualitative study
SO JOURNAL OF CLINICAL NURSING
LA English
DT Article
DE healing by secondary intention; nurses; open surgical wounds;
   qualitative; surgeons
ID VACUUM-ASSISTED CLOSURE; THERAPY; PREVALENCE; CARE
AB Aims and Objectives To explore surgeons' and nurses' perspectives of managing surgical wounds healing by secondary intention.
   Background Every year, more than 10 million surgical operations are performed in the NHS in the UK. Most surgical wounds heal by primary intention, where the edges of the wound are brought together with staples, sutures, adhesive glue or clips. Sometimes wounds are deliberately left open to heal, from the base up, known as "healing by secondary intention." These wounds are often slow to heal, prone to infection and complex to manage.
   Design A qualitative, descriptive approach, using semi-structured interviews.
   Methods Interviews with five (general, vascular and plastic) surgeons and 7 nurses (3 tissue viability nurses, 2 district and 1 community nurse, and 1 hospital nurse) working in hospital and community care settings in two locations in the north of England. Data analysis followed the recommended sequential steps of "Framework" approach. Consolidated criteria for reporting qualitative research guided the study report.
   Results Participants reported that the main types of wounds healing by secondary intention that they manage are extensive abdominal cavity wounds; open wounds relating to treatment for pilonidal sinus; large open wounds on the feet of patients with diabetes; and axilla and groin wounds, associated with removal of lymph nodes for cancer. Infection and prolonged time to healing were the main challenges. Negative pressure wound therapy was the most favoured treatment option.
   Conclusions Negative pressure wound therapy was advocated by professionals despite a lack of research evidence indicating clinical or cost-effectiveness. Our findings underscore the need for rigorous evaluation of negative pressure wound therapy, and other wound care treatments, through studies that include economic evaluation.
   Relevance for clinical practice Clinical decision-making in wound care could be optimised through further robust studies to inform practitioners about the cost-effectiveness of available treatments.
C1 [McCaughan, Dorothy] Univ York, Dept Hlth Sci, Seebohm Rowntree Bldg, York YO10 5DD, N Yorkshire, England.
   [Sheard, Laura] Bradford Inst Hlth Res, Bradford, W Yorkshire, England.
   [Cullum, Nicky] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Nursing, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
   [Dumville, Jo] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Appl Hlth Res, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
   [Cullum, Nicky] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Res & Innovat Div, Nursing, Manchester, Lancs, England.
   [Chetter, Ian] Univ Hull, Hull York Med Sch, Acad Vasc Surg Unit, Surg, Kingston Upon Hull, N Humberside, England.
   [Chetter, Ian] East Yorkshire NHS Trust, Surg, Kingston Upon Hull, N Humberside, England.
C3 University of York - UK; University of Manchester; University of
   Manchester; University of Manchester; Manchester University NHS
   Foundation Trust; University of York - UK; University of Hull
RP McCaughan, D (通讯作者)，Univ York, Dept Hlth Sci, Seebohm Rowntree Bldg, York YO10 5DD, N Yorkshire, England.
EM dorothy.mccaughan@york.ac.uk
RI ; Dumville, Jo/O-7867-2014; Cullum, Nicky/F-2438-2011
OI chetter, ian/0000-0002-2566-6859; Dumville, Jo/0000-0002-6546-3685;
   Cullum, Nicky/0000-0003-2631-123X; McCaughan,
   Dorothy/0000-0001-5388-2455
FU National Institute for Health Research (NIHR, UK) Programme Grants for
   Applied Research; National Institute for Health Research
   [RP-PG-0609-10171] Funding Source: researchfish; National Institutes of
   Health Research (NIHR) [RP-PG-0609-10171] Funding Source: National
   Institutes of Health Research (NIHR)
FX This study was funded by the National Institute for Health Research
   (NIHR, UK) Programme Grants for Applied Research: Application
   RP-PG-0609-10171-surgical wounds healing by secondary intention:
   characterising and quantifying the problem and identifying effective
   treatments.
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NR 44
TC 9
Z9 12
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD JUL
PY 2020
VL 29
IS 13-14
BP 2557
EP 2571
DI 10.1111/jocn.15279
EA APR 2020
PG 15
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA LZ4YB
UT WOS:000527779900001
PM 32279371
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Seidel, D
   Storck, M
   Lawall, H
   Wozniak, G
   Mauckner, P
   Hochlenert, D
   Wetzel-Roth, W
   Sondern, K
   Hahn, M
   Rothenaicher, G
   Krönert, T
   Zink, K
   Neugebauer, E
AF Seidel, Doerthe
   Storck, Martin
   Lawall, Holger
   Wozniak, Gernold
   Mauckner, Peter
   Hochlenert, Dirk
   Wetzel-Roth, Walter
   Sondern, Klemens
   Hahn, Matthias
   Rothenaicher, Gerhard
   Kroenert, Thomas
   Zink, Karl
   Neugebauer, Edmund
TI Negative pressure wound therapy compared with standard moist wound care
   on diabetic foot ulcers in real-life clinical practice: results of the
   German DiaFu-RCT
SO BMJ OPEN
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; AMPUTATION
AB Objectives The aim of the DiaFu study was to evaluate effectiveness and safety of negative pressure wound therapy (NPWT) in patients with diabetic foot wounds in clinical practice.
   Design In this controlled clinical superiority trial with blinded outcome assessment patients were randomised in a 1:1 ratio stratified by study site and ulcer severity grade using a web-based-tool.
   Setting This German national study was conducted in 40 surgical and internal medicine inpatient and outpatient facilities specialised in diabetes foot care.
   Participants 368 patients were randomised and 345 participants were included in the modified intention-to-treat (ITT) population. Adult patients suffering from a diabetic foot ulcer at least for 4 weeks and without contraindication for NPWT were allowed to be included.
   Interventions NPWT was compared with standard moist wound care (SMWC) according to local standards and guidelines.
   Primary and secondary outcome measures Primary outcome was wound closure within 16 weeks. Secondary outcomes were wound-related and treatment-related adverse events (AEs), amputations, time until optimal wound bed preparation, wound size and wound tissue composition, pain and quality of life (QoL) within 16 weeks, and recurrences and wound closure within 6 months.
   Results In the ITT population, neither the wound closure rate (difference: n=4 (2.5% (95% CI-4.7% - 9.7%); p=0.53)) nor the time to wound closure (p=0.244) was significantly different between the treatment arms. 191 participants (NPWT 127; SMWC 64) had missing endpoint documentations, premature therapy ends or unauthorised treatment changes. 96 participants in the NPWT arm and 72 participants in the SMWC arm had at least one AE (p=0.007), but only 16 AEs were related to NPWT.
   Conclusions NPWT was not superior to SMWC in diabetic foot wounds in German clinical practice. Overall, wound closure rate was low. Documentation deficits and deviations from treatment guidelines negatively impacted the outcome wound closure.
C1 [Seidel, Doerthe] Univ Witten Herdecke, IFOM, Cologne, Germany.
   [Storck, Martin] Stadtisches Klinikum Karlsruhe gGmbH, Klin Gefass & Thoraxchirurg, Karlsruhe, Germany.
   [Lawall, Holger] Max Grundig Klin, Innere Med, Buhlerhohe, Germany.
   [Wozniak, Gernold] Knappschaftskrankenhaus Bottrop GmbH, Gefasschirurg Klin, Bottrop, Germany.
   [Mauckner, Peter] St Remigius Krankenhaus Opladen, Innere Med, Leverkusen, Germany.
   [Hochlenert, Dirk] Gemeinschaftspraxis Schlotmann Hochlenert Zavalet, Cologne, Germany.
   [Wetzel-Roth, Walter] Chirurg Praxis Wetzel Roth, Buchloe, Germany.
   [Sondern, Klemens] Marien Hosp Dortmund Hombruch, Klin Innere Med Diabetol, Dortmund, Germany.
   [Hahn, Matthias] Helfenstein Klin, Allgemein & Viszeralchirurg, Geisslingen, Germany.
   [Rothenaicher, Gerhard] Chirurg Praxis Rothenaicher, Munich, Germany.
   [Kroenert, Thomas] Thuringen Kliniken Georgius Agr GmbH, Klin Gefasschirurg, Saalfeld, Germany.
   [Zink, Karl] Diabet Zentrum Mergentheim, Diabet Klin, Bad Mergentheim, Germany.
   [Neugebauer, Edmund] Univ Witten Herdecke, Dept Humanmed, Witten, Germany.
   [Neugebauer, Edmund] Med Hsch Brandenburg Theodor Fontane, Neuruppin, Germany.
C3 Witten Herdecke University; Witten Herdecke University
RP Seidel, D (通讯作者)，Univ Witten Herdecke, IFOM, Cologne, Germany.
EM Doerthe.Seidel@uni-wh.de
RI /L-6893-2017
FU KCI; SN
FX Through a European tender, the study was initiated by a consortium of 19
   statutory German health insurance funds, which provided integrated care
   contracts for all study participants and for up to 7000 patients with
   acute and chronic wounds in Germany; defined basic rules for study
   design based on the requirements of the German authorities; and provided
   a critical review of the study protocol and the final report. The study
   was funded by the manufacturers KCI and S&N. Both companies provided the
   NPWT devices and associated consumable supplies in the assigned regions
   of Germany as well as all necessary support and information about the
   used material. All authors had full access to all of the data (including
   statistical reports and tables) in the study and take full
   responsibility for the accuracy of the data analysis.
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NR 33
TC 68
Z9 88
U1 4
U2 24
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAR
PY 2020
VL 10
IS 3
AR e026345
DI 10.1136/bmjopen-2018-026345
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LG0KT
UT WOS:000527801000001
PM 32209619
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Shakir, S
   Messa, CA
   Broach, RB
   Rheumtulla, IA
   Chatman, B
   D'Angelantonio, A
   Levin, LS
   Kovach, SJ 
   Serletti, JM
   Fischer, JP
AF Shakir, Sameer
   Messa, Charles A.
   Broach, Robyn B.
   Rheumtulla, Irfan A.
   Chatman, Brett
   D'Angelantonio, Albert
   Levin, L. Scott
   Kovach, Stephen J., III
   Serletti, Joseph M.
   Fischer, John P.
TI Indications and Limitations of Bilayer Wound Matrix-Based Lower
   Extremity Reconstruction: A Multidisciplinary Case-Control Study of 191
   Wounds
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID OUTCOMES; FLAP; DEFECTS; INTEGRA; FOOT
AB Background:
   Little is known about the efficacy of newer skin substitute scaffolds to reconstruct complex lower extremity wounds. The investigators present a multihospital experience of reconstructive surgeons utilizing collagen-GAG bilayer wound matrix in lower extremity soft-tissue reconstruction with the goals to (1) characterize a suitable patient population, (2) categorize failures to optimize patient selection, and (3) determine wound factors affecting success.
   Methods:
   Subjects underwent collagen-GAG-based lower extremity wound reconstruction from May of 2010 to June of 2017. The primary outcome variable was 180-day graft success, defined as eventual split-thickness skin grafting after bilayer wound matrix application; failure was defined as inadequate wound bed for split-thickness skin grafting, requirement for vascularized tissue transfer, or eventual amputation. Eligible subjects had at least one lower extremity wound and were at least 18 years old. Exclusion criteria included third-degree burn wounds or failure to follow up for at least 60 days postoperatively. Predictor variables included demographics, medical comorbidities, perioperative characteristics, postoperative complications, and cost-related data for each hospitalization.
   Results:
   There were 147 subjects with 191 wounds. Mean patient age was 60.1 years (range, 21.0 to 95.6 years), and mean body mass index was 30.5 kg/m(2) (range, 14.4 to 64.7 kg/m(2)). Average wound size was 73.1 +/- 137.7 cm(2), with 49.0 percent of subjects receiving adjunct postoperative negative-pressure wound therapy. Seventy percent of wounds were successfully healed at 180 days. Most were localized between the knee and ankle (50.8 percent) or foot (46.1 percent). Tendon exposure (p < 0.05), bone exposure (p < 0.01), and bone excision (p < 0.04) were associated with reconstructive failure.
   Conclusions:
   The authors present the largest reported multihospital, multidisciplinary experience with collagen-GAG wound matrix for lower extremity reconstruction. Tendon and/or bone exposure and socioeconomic factors were associated with failure.
C1 Univ Penn, Dept Surg, Div Plast Surg, Philadelphia, PA 19104 USA.
   Univ Penn, Dept Orthoped Surg, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania
RP Fischer, JP (通讯作者)，Univ Penn, Div Plast Surg, 14th Floor,South Pavil,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
EM John.Fischer2@uphs.upenn.edu
RI ; Messa, Charles/AAK-6833-2021
OI Shakir, Sameer/0000-0003-0992-0308; 
CR Bekara F, 2016, PLAST RECONSTR SURG, V137, P314, DOI 10.1097/PRS.0000000000001891
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NR 16
TC 33
Z9 36
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAR
PY 2020
VL 145
IS 3
BP 813
EP 822
DI 10.1097/PRS.0000000000006609
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LH1TC
UT WOS:000528570700067
PM 32097330
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Sherman, G
   Shulman-Manor, O
   Dagan, O
   Livni, G
   Scheuerman, O
   Amir, G
   Frenkel, G
   Levy, I
AF Sherman, Gilad
   Shulman-Manor, Orit
   Dagan, Ovadia
   Livni, Gilat
   Scheuerman, Oded
   Amir, Gabriel
   Frenkel, George
   Levy, Itzhak
TI Vacuum-Assisted Closure for the Treatment of Deep Sternal Wound
   Infection After Pediatric Cardiac Surgery
SO PEDIATRIC CRITICAL CARE MEDICINE
LA English
DT Article
DE children; sternal wound infection; vacuum-assisted closure
ID POST-STERNOTOMY MEDIASTINITIS; POSTSTERNOTOMY MEDIASTINITIS;
   POSTOPERATIVE MEDIASTINITIS; NEGATIVE PRESSURES; MANAGEMENT; DRAINAGE
AB Objectives:
   Vacuum-assisted closure is being increasingly used to treat deep sternal wound infection following cardiac surgery, but most of the data refer to adults. This study investigated the safety and efficacy of vacuum-assisted closure in pediatric patients.
   Design:
   Retrospective file review.
   Setting:
   Tertiary pediatric medical center.
   Patients:
   All children with deep sternal wound infection treated with vacuum-assisted closure in 2003-2016.
   Interventions:
   Epidemiological, clinical, and microbiological data were collected from the medical records.
   Measurements and Main Results:
   The cohort included 50 patients (0.9% of cardiac patients operated during the study period) of median age 6.5 months (interquartile range, 2-12.75 mo; range, 1 wk to 14 yr) and median weight 5.1 kg (interquartile range, 4-9.75 kg). The most frequent heart defects were tetralogy of Fallot (22%) and ventricular septal defect (20%); 38% of patients had cyanotic heart disease. Deep sternal wound infections appeared a median of 10 days postoperatively (interquartile range, 7-14 d; range 3-100 d). Vacuum-assisted closure was applied a median of 13 days postoperatively (interquartile range, 10-18.5 d; range, 5-103 d) for a median duration of 10 days (interquartile range, 7-13.25 d; range, 1-21 d). Wound cultures were positive in 48 patients (96%); most isolates were Gram-positive (76%). The main bacterial pathogen was methicillin-susceptible Staphylococcus aureus (61%). Most patients were treated with cloxacillin for a median of 38 days (interquartile range, 28-42 d; range, 9-189 d). There were no statistically significant differences in clinical or treatment characteristics between bacteremic (56%) and nonbacteremic patients. Compared with older patients, infants less than 3 months old (36%) had a significantly longer hospitalization time (41 vs 25 d; p = 0.001) and higher Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Mortality Category (3 vs 2; p = 0.003). All cases except one (contact dermatitis) were uneventful. In 10 patients, wounds were closed surgically after vacuum-assisted closure. Two patients required a pectoralis flap, both treated before 2005. One of the two deaths was infection-related.
   Conclusions:
   Vacuum-assisted closure is a feasible treatment option of deep sternal wound infection after pediatric cardiac surgery and was not associated with independent morbidity.
C1 [Sherman, Gilad; Scheuerman, Oded; Levy, Itzhak] Schneider Childrens Med Ctr Israel, Infect Dis Unit, Petah Tiqwa, Israel.
   [Sherman, Gilad; Shulman-Manor, Orit; Dagan, Ovadia; Livni, Gilat; Scheuerman, Oded; Amir, Gabriel; Levy, Itzhak] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
   [Shulman-Manor, Orit; Dagan, Ovadia; Amir, Gabriel; Frenkel, George] Schneider Childrens Med Ctr Israel, Pediat Cardiac Intens Care Unit, Petah Tiqwa, Israel.
   [Livni, Gilat] Schneider Childrens Med Ctr Israel, Dept Pediat A, Petah Tiqwa, Israel.
   [Scheuerman, Oded] Schneider Childrens Med Ctr Israel, Dept Pediat B, Petah Tiqwa, Israel.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv University; Tel Aviv University; Tel Aviv University
RP Levy, I (通讯作者)，Schneider Childrens Med Ctr Israel, Infect Dis Unit, Petah Tiqwa, Israel.; Levy, I (通讯作者)，Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
EM itzhakl@clalit.org.il
RI Sherman, Gilad/MTG-4350-2025
OI Sherman, Gilad/0000-0001-9290-6667
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 25
TC 9
Z9 15
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1529-7535
EI 1947-3893
J9 PEDIATR CRIT CARE ME
JI Pediatr. Crit. Care Med.
PD FEB
PY 2020
VL 21
IS 2
BP 150
EP 155
DI 10.1097/PCC.0000000000002131
PG 6
WC Critical Care Medicine; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pediatrics
GA LH6KK
UT WOS:000528892100011
PM 31568260
DA 2026-07-24
ER
PT J
AU Chan, KS
   Arunaachalam, M
   Hong, QT
   Yong, EM
   Lingam, P
   Zhang, L
   Chandrasekar, S
   Tan, GWL
   Lo, ZJ
AF Chan, Kai Siang
   Arunaachalam, Muthaiah
   Hong, Qiantai
   Yong, En Ming
   Lingam, Pravin
   Zhang, Li
   Chandrasekar, Sadhana
   Tan, Glenn Wei Leong
   Lo, Zhiwen Joseph
TI Outcomes of incisional negative pressure wound therapy following
   brachiobasilic transposition arteriovenous fistula creation: A 1:2
   propensity score matched study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure wound therapy; arteriovenous shunt; surgical;
   arteriovenous fistula; brachiobasilic transposition
ID SURGICAL SITE INFECTION; VASCULAR-SURGERY; PREVENTION; GUIDELINE; RISK
AB Incisional negative wound pressure therapy (iNPWT) use on closed incisions has been shown to improve wound outcomes, but no studies have evaluated the use of iNPWT following brachiobasilic transposition arteriovenous fistula (BBT-AVF). We aim to investigate the efficacy of iNPWT vs conventional wound therapy in reducing surgical site infections (SSIs) for BBT-AVF incisions. This is a retrospective cohort study of patients who underwent BBT-AVF creation between January 2010 and December 2017. A 1:2 propensity score matching (PSM) was performed to reduce selection bias and address for confounding factors. Study outcomes included SSI and haematoma incidence, 30-day readmission, and 30-day mortality. A total of 154 patients were reviewed in this study: 47 (30.5%) had iNPWT and 107 (69.5%) had conventional wound therapy. The overall median age was 60.5 (interquartile range 54-69). PSM with a 1:2 ratio resulted in a total of 117 patients (39 iNPWT and 78 conventional wound therapy). In the unmatched cohort, SSI incidence was lower in the iNPWT group (n = 1/47 [2.1%] vs n = 14/107 [13.1%], P = .035). However, incidence of SSI was comparable between iNPWT and conventional wound therapy after matching (n = 1/39 [2.6%] vs n = 9/78 [11.5%], P = .102). There was no significant difference in 30-day readmission and 30-day mortality. Within our study population of patients with BBT-AVF incisions, there is a non-statistically significant reduction in SSI incidence for patients who received iNPWT as compared with conventional wound therapy. Further prospective randomised controlled studies should be conducted to validate these findings.
C1 [Chan, Kai Siang] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore.
   [Arunaachalam, Muthaiah] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Chan, Kai Siang; Arunaachalam, Muthaiah; Hong, Qiantai; Yong, En Ming; Lingam, Pravin; Zhang, Li; Chandrasekar, Sadhana; Tan, Glenn Wei Leong; Lo, Zhiwen Joseph] Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
C3 Nanyang Technological University; National University of Singapore; Tan
   Tock Seng Hospital
RP Chan, KS (通讯作者)，Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
EM kchan023@e.ntu.edu.sg
RI ; Yong, Enming/LXB-4566-2024; Lingam, Pravin/ODK-1133-2025
OI Chanasekar, Sadhana/0000-0002-3650-8020; Chan, Kai
   Siang/0000-0001-9533-801X; LO, ZHIWEN JOSEPH/0000-0003-2289-5266; Yong,
   Enming/0000-0002-9461-0066; 
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
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NR 28
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1231
EP 1238
DI 10.1111/iwj.13376
EA APR 2020
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000529141800001
PM 32347016
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Huang, ZG
   Lei, C
   Zhang, L
   Xue, HD
   Shen, J
   Wu, SY
   Wang, B
   Chen, JW
AF Huang, Zugen
   Lei, Chen
   Zhang, Ling
   Xue, Huadong
   Shen, Jian
   Wu, Shanying
   Wang, Biao
   Chen, Jianwu
TI Negative Pressure Wound Therapy With Chymotrypsin Irrigation: A Maximal
   Implant Retention Procedure Treating the Exposure/Infection of Titanium
   Mesh in Cranioplasty
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Chymotrypsin; cranioplasty; implant-related infection; negative pressure
   wound therapy; titanium mesh
ID RETROSPECTIVE ANALYSIS; SCALP THICKNESS; COMPLICATIONS; INFECTION;
   INSTILLATION; COST; RISK; TIME
AB This preliminary study aims to investigate the effects of a maximal implant retention procedure. The authors retrospectively reviewed the use of negative pressure wound therapy with chymotrypsin irrigation treating implant infection/exposure in titanium mesh cranioplasty by comparing patients with titanium mesh totally retained, partially removed, or totally removed according to the evaluation during the surgery. Negative pressure wound therapy with chymotrypsin irrigation was applied 5 days after the surgery. The negative pressure was set at -125 to -150 mmHg. A total of 21 patients were included, 4 patients treated with titanium mesh totally removed; 3 patients treated with titanium mesh partially removed; and 14 patients treated with U-shape debridement with titanium mesh preserved completely. However, 1 patient in the U-shape group required a second debridement to remove all implant. Negative pressure wound therapy with chymotrypsin irrigation is a novel procedure and could be used to treat implant-related infection without the exchange of implant.
C1 [Huang, Zugen; Lei, Chen; Zhang, Ling; Xue, Huadong; Shen, Jian; Wu, Shanying; Wang, Biao] Fujian Med Univ, Dept Plast Surg, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China.
   [Chen, Jianwu] Fujian Med Univ, Dept Neurosurg, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China.
C3 Fujian Medical University; Fujian Medical University
RP Wang, B (通讯作者)，Fujian Med Univ, Dept Plast Surg, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China.; Chen, JW (通讯作者)，Fujian Med Univ, Dept Neurosurg, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China.
EM 1812166371@qq.com; fzcjw@sina.com
RI Zhang, LingKang/KYQ-2776-2024
FU Natural Science Foundation of China [81801931]; Fujian Provincial Key
   Clinical Specialty Discipline Construction Program [2016-SLCZD]; Fujian,
   Provincial Natural Science Foundation Program [2018J01154, 2018J01163];
   Project of the Maxillofacial Medical Center in Fujian Province, Start-up
   Foundation of Fujian Medical University [2017XQ1059]; Scientific
   Research Foundation of National Health Planning Scientific Research
   Foundation-Joint Research Projects of Fujian Provincial Health and
   Education [2019-WJ-09]; Special Supported Funds of Fujian Provincial
   Finance Department [BPB-WB2016]
FX This work was supported by the Natural Science Foundation of China
   (81801931), Fujian Provincial Key Clinical Specialty Discipline
   Construction Program (2016-SLCZD), Fujian, Provincial Natural Science
   Foundation Program (2018J01154, 2018J01163), the Project of the
   Maxillofacial Medical Center in Fujian Province, Start-up Foundation of
   Fujian Medical University (2017XQ1059). Scientific Research Foundation
   of National Health Planning Scientific Research Foundation-Joint
   Research Projects of Fujian Provincial Health and Education
   (2019-WJ-09). Special Supported Funds of Fujian Provincial Finance
   Department (BPB-WB2016).
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NR 38
TC 4
Z9 5
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD MAR-APR
PY 2020
VL 31
IS 2
BP 522
EP 526
DI 10.1097/SCS.0000000000006214
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LI3AC
UT WOS:000529353700096
PM 31977700
DA 2026-07-24
ER
PT J
AU Eisendle, K
   Thuile, T
   Deluca, J
   Pichler, M
AF Eisendle, Klaus
   Thuile, Tobias
   Deluca, Jenny
   Pichler, Maria
TI Surgical Treatment of Pyoderma Gangrenosum with Negative Pressure Wound
   Therapy and Skin Grafting, Including Xenografts: Personal Experience and
   Comprehensive Review on 161 Cases
SO ADVANCES IN WOUND CARE
LA English
DT Review
DE pyoderma gangrenosum; skin graft; negative pressure wound therapy;
   xenotransplant; ustekinumab; infliximab
ID VACUUM-ASSISTED CLOSURE; MYCOPHENOLATE-MOFETIL; BREAST RECONSTRUCTION;
   LEG ULCERS; TNF-ALPHA; REDUCTION MAMMAPLASTY; EFFECTIVE STRATEGIES;
   ULCERATIVE-COLITIS; CLINICAL-FEATURES; HYPERBARIC-OXYGEN
AB Significance: Pyoderma gangrenosum (PG) is a rare debilitating autoinflammatory ulcerative skin disease. No gold standard has been established for the treatment of PG. The role of surgical interventions and negative pressure wound therapy (NPWT) was discussed controversially until recently as these procedures might pose a trigger to further aggravate the condition.
   Recent Advances: Recent advances confirm the paradigm change that a surgical approach of PG with split thickness skin grafting (STSG) secured by NPWT is a safe and valuable treatment if performed under adequate immunosuppression. We elaborate this on the hand of a broad literature search retrieving 101 relevant articles describing 138 patients complemented with our personal experience on 23 patients, including 2 patients treated with a porcine xenodressing.
   Critical Issues: A wide range of surgical approaches have been reported, including xenografts. Treatment was finally successful in 86%, including the xenotransplant cases. Ten percent improved and failures were mainly reported without immunosuppression. Despite halting the inflammatory process, NPWT alone, without skin grafting, does not much accelerate healing time. The best surgical approach appears to be STSG fixed with NPWT as this leads to higher skin graft take. There remains the problem of the chronic nature of PG and the recurrence after tapering of immunosuppression or trauma; therefore, a sustained immunosuppressive treatment is suggested.
   Future Directions: While surgical treatment is supported by the published data, the exact immunosuppression is still evolving. Due to deeper insights into pathogenesis and growing clinical reports, a broader utilization of biologic treatments and a shift from tumor necrosis factor (TNF)-alpha to interleukin (IL)-12/23 or IL-23 antibodies alone are predictable, as IL-12/23 antibodies show good clinical responses with fewer side effects. The positive results with porcine xenodressings might be due to immunological effects of the xenomaterial; they appear promising, but are preliminary and should be confirmed in a larger patient collective.
C1 [Eisendle, Klaus; Thuile, Tobias; Deluca, Jenny; Pichler, Maria] Med Univ Innsbruck, Cent Teaching Hosp Bolzano Bozen, Acad Teaching Dept, Dept Dermatol Venereol & Allergol, Bohlerstr 5, I-39100 Bolzano, Italy.
   [Eisendle, Klaus] Coll Hlth Care Profess, MREST Interdisciplinary Med Res Ctr South Tyrol, Bolzano, Italy.
C3 Krankenhaus Bozen
RP Eisendle, K (通讯作者)，Med Univ Innsbruck, Cent Teaching Hosp Bolzano Bozen, Acad Teaching Dept, Dept Dermatol Venereol & Allergol, Bohlerstr 5, I-39100 Bolzano, Italy.
EM klauseisendle@hotmail.com
RI Eisendle, Klaus/H-6798-2019
OI Eisendle, Klaus/0000-0002-8234-9964
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NR 199
TC 44
Z9 51
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUL 1
PY 2020
VL 9
IS 7
BP 405
EP 425
DI 10.1089/wound.2020.1160
EA APR 2020
PG 21
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA LW9PZ
UT WOS:000529989000001
PM 32320362
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hasselmann, J
   Bjork, J
   Svensson-Bjork, R
   Butt, T
   Acosta, S
AF Hasselmann, Julien
   Bjork, Jonas
   Svensson-Bjork, Robert
   Butt, Talha
   Acosta, Stefan
TI Proposed Classification of Incision Complications: Analysis of a
   Prospective Study on Elective Open Lower-Limb Revascularization
SO SURGICAL INFECTIONS
LA English
DT Article
DE complication classification; inguinal arterial revascularization;
   infra-inguinal arterial revascularization
ID SURGICAL SITE INFECTION; RISK-FACTORS; WOUND INFECTIONS; SURGERY; COSTS;
   OUTCOMES; BYPASS; CARE
AB Background: Incision complications (IC) have a significant impact on procedure-related morbidity after lower-limb revascularization. One of the most studied IC is surgical site infection (SSI). Reporting these complications in a uniform way is crucial to evaluate treatment approaches. The aim of this study was to propose a comprehensive classification of IC and apply it to compare SSI with other IC in a trial on elective open lower-limb revascularization procedures.
   Methods: Two hundred twenty-three eligible patients undergoing elective unilateral inguinal and infra-inguinal arterial vascular surgery were extracted from a randomized controlled trial on incisional negative-pressure wound therapy (NPWT) on inguinal vascular surgical incisions. The IC were classified by grades of severity (grade 0-6) that focused on IC-related consequences such as out-patient treatment (grade 1), prolonged in-patient treatment (grade 2), re-admission (grade 3), and re-operation (grade >= 4). An SSI was defined by the ASEPSIS score criteria.
   Results: An SSI was diagnosed in 63 patients (28.3%). Thirty-five of 160 patients (21.8%) not suffering from SSI underwent IC treatment. Treatment for IC was recorded for 25/144 patients (17.4%) with satisfactory site healing as judged by the ASEPSIS score. The median incision-related in-hospital stay in those with SSI (n = 79) and disturbed healing (n = 16) according to the ASEPSIS score was 13 days in both groups (p = 0.53). Five patients had peri-vascular SSI (IC grade 4 n = 4; grade 5 n = 1). The proposed classification of IC and the ASEPSIS score correlated highly (r = 0.77; p < 0.001). Inter-rater reliability for IC grading was substantial for three investigators with different levels of experience (k = 0.81, 0.71, and 0.70).
   Conclusions: The proposed incision classification suggests a comparable clinical significance of vascular IC in terms of IC-related in-patient stay, whether there was a surgical site infection or not. This classification system requires external validation.
C1 [Hasselmann, Julien; Svensson-Bjork, Robert; Butt, Talha; Acosta, Stefan] Skane Univ Hosp, Vasc Ctr, Malmo, Sweden.
   [Hasselmann, Julien; Svensson-Bjork, Robert; Butt, Talha; Acosta, Stefan] Lund Univ, Dept Clin Sci, Ruth Lundskogs Gata 10, Malmo 20502, Sweden.
   [Bjork, Jonas] Lund Univ, Div Occupat & Environm Med, Malmo, Sweden.
   [Bjork, Jonas] Lund Univ Hosp, Forum South, Clin Studies Sweden, Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Lund
   University; Lund University; Skane University Hospital
RP Hasselmann, J (通讯作者)，Lund Univ, Dept Clin Sci, Ruth Lundskogs Gata 10, Malmo 20502, Sweden.
EM Hasselmann999@gmail.com
RI Acosta, Stefan/JAX-3225-2023; Björk, Jonas/AFS-4819-2022; Hasselmann,
   Julien/C-1586-2015
OI Acosta, Stefan/0000-0002-3225-0798; Björk, Jonas/0000-0003-1883-2000;
   Svensson-Björk, Robert/0000-0003-1907-9022
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NR 19
TC 6
Z9 6
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD MAY 1
PY 2020
VL 21
IS 4
BP 384
EP 390
DI 10.1089/sur.2019.144
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA LJ2YR
UT WOS:000530035700011
PM 31829833
DA 2026-07-24
ER
PT J
AU Singh, D
   Chopra, K
   Sabino, J
   Brown, E
AF Singh, Devinder
   Chopra, Karan
   Sabino, Jennifer
   Brown, Emile
TI Practical Things You Should Know about Wound Healing and Vacuum-Assisted
   Closure Management
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID NEGATIVE-PRESSURE THERAPY; HYPERBARIC-OXYGEN THERAPY; CLOSED INCISION
   MANAGEMENT; INDOCYANINE GREEN; FLUORESCENCE ANGIOGRAPHY; OBESE-PATIENTS;
   DOUBLE-BLIND; INSTILLATION; COMPLICATIONS; INFECTIONS
AB Learning Objectives: After reading this article, the participant should be able to: 1. Understand the basics of negative-pressure wound therapy and practical uses of various vacuum-assisted closure dressings. 2. Understand the mechanisms of action of negative-pressure therapies and other important adjuncts, such as perfusion imaging. 3. Discuss the evidence for hyperbaric oxygen therapy in wound care.
   Summary: Wound healing requires creating an environment that supports the healing process while decreasing inflammation and infection. Negative-pressure wound therapy has changed the way physicians manage acute and chronic wounds for more than 20 years. It contracts wound edges, removes exudate, including inflammatory and infectious material, and promotes angiogenesis and granulation tissue formation. These effects have been consistently demonstrated in multiple animal and human randomized controlled trials. Recent innovations that include instillation therapy and closed incision have further increased our arsenal against difficult-to-treat wounds and incisions at high risk of complications. Instillation of topical wound solutions allows physicians to cleanse the wound without return to the operating room, resulting in fewer debridements, shorter hospital stays, and faster time to wound closure. Other concepts have yielded negative-pressure therapy on top of closed surgical incisions, which holds incision edges together, reduces edema, promotes angiogenesis, and creates a barrier to protect incisions during the critical healing period, thereby reducing surgical-site complications, especially infection. Other practical adjuncts to the modern-day treatment of acute and chronic wounds include indocyanine green angiography, which allows real-time assessment of perfusion, and hyperbaric oxygen treatment, which has been suggested to augment healing in acute, chronic, specifically diabetic foot ulcers and radiation-related wounds.
C1 [Singh, Devinder] Anne Arundel Med Ctr, Div Plast Surg, 2000 Med Pkwy,Belcher Pavil,Suite 200, Annapolis, MD 21401 USA.
   Johns Hopkins Univ Hosp, Dept Plast Surg, Baltimore, MD 21287 USA.
   Madigan Army Med Ctr, Joint Base Lewis Mcchord, WA USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; Madigan Army Medical
   Center
RP Singh, D (通讯作者)，Anne Arundel Med Ctr, Div Plast Surg, 2000 Med Pkwy,Belcher Pavil,Suite 200, Annapolis, MD 21401 USA.
EM dsingh.MD@gmail.com
RI Singh, Devinder/AAN-4716-2021
CR [Anonymous], PODIATRY MANAGE
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NR 83
TC 32
Z9 40
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR
PY 2020
VL 145
IS 4
BP 839E
EP 854E
DI 10.1097/PRS.0000000000006652
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LK1KX
UT WOS:000530618900020
PM 32221237
DA 2026-07-24
ER
PT J
AU Syllaios, A
   Davakis, S
   Karydakis, L
   Vailas, M
   Garmpis, N
   Mpaili, E
   Kyros, E
   Felekouras, E
   Papalampros, A
AF Syllaios, Athanasios
   Davakis, Spyridon
   Karydakis, Lysandros
   Vailas, Michail
   Garmpis, Nikolaos
   Mpaili, Efstratia
   Kyros, Eleandros
   Felekouras, Evangelos
   Papalampros, Alexandros
TI Treatment of Fournier's Gangrene With Vacuum-assisted Closure Therapy as
   Enhanced Recovery Treatment Modality
SO IN VIVO
LA English
DT Article
DE Fournier's Gangrene; vacuum-assisted closure therapy; wound healing
AB Background/Aim: Fournier's gangrene is an uncommon, but extremely serious condition of necrotizing, soft tissue infection. There is a great debate regarding the management of larger defects and wound closure, with various techniques being described in the current literature. We aimed to present the surgical management of extensive Fournier's gangrene treated successfully with Vacuum-assisted closure (VAC) therapy, a novel approach to treatment algorithm that can lead to a paradigm shift. Case: A 66-year-old male patient with Fournier's gangrene was treated with extensive surgical debridement, protective colostomy and VAC therapy. Results: After initial extensive surgical debridement, VAC therapy significantly improved the clinical and aesthetic condition of the patient. Conclusion: VAC therapy in Fournier's gangrene patients may be a safe and effective technique with favorable clinical outcomes, by improving and enhancing wound healing and recovery.
C1 [Syllaios, Athanasios; Davakis, Spyridon; Karydakis, Lysandros; Vailas, Michail; Mpaili, Efstratia; Kyros, Eleandros; Felekouras, Evangelos; Papalampros, Alexandros] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Dept Surg 1, Athens, Greece.
   [Garmpis, Nikolaos] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Propedeut Dept Surg 2, Athens, Greece.
C3 National & Kapodistrian University of Athens; Laiko General Hospital;
   National & Kapodistrian University of Athens; Laiko General Hospital
RP Garmpis, N (通讯作者)，Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Propedeut Dept Surg 2, Athens, Greece.
EM nikosg22@hotmail.com
RI Baili, Efstratia/AAE-3367-2019
OI Baili, Efstratia/0000-0001-8745-2269; Syllaios,
   Athanasios/0000-0002-5053-0953; Vailas, Michail/0000-0002-7357-6532
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NR 8
TC 13
Z9 22
U1 0
U2 1
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD MAY-JUN
PY 2020
VL 34
IS 3
BP 1499
EP 1502
DI 10.21873/invivo.11936
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LK2IP
UT WOS:000530682800074
PM 32354953
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Vana, LPM
   Battlehner, CN
   Ferreira, MA
   Caldini, EG
   Gemperli, R
   Alonso, N
AF Molina Vana, Luiz Philipe
   Battlehner, Claudia Naves
   Ferreira, Marcelo Alves
   Caldini, Elia Garcia
   Gemperli, Rolf
   Alonso, Nivaldo
TI Comparative long-term study between two dermal regeneration templates
   for the reconstruction of burn scar contractures in humans: Clinical and
   histological results
SO BURNS
LA English
DT Article
DE Negative-pressure wound therapy; Dermal regeneration template;
   Artificial skin; Integra; Matriderm
ID NEGATIVE-PRESSURE THERAPY; INTEGRA ARTIFICIAL SKIN; INTERRATER
   RELIABILITY; WOUND THERAPY; THICKNESS; SUBSTITUTES; DEFECTS; SURGERY;
   PATIENT; DESIGN
AB The advent of dermal regeneration templates has fostered major advances in the treatment of acute bums and their sequelae, in the last three decades. Both data on morphological aspects of the newly-formed tissue, and clinical trials comparing different templates, are few. The goal of this study was to prospectively analyze the outcome of randomized patients treated with two of the existing templates, followed by thin skin autograft. They are both 2mm-thick bovine collagen templates (Matriderm (R) and Integra (R)), the latter includes a superficial silicone layer. Surgery was performed on patients with impaired mobility resulting from bum sequelae (n =12 per template) in a two-step procedure. Negative pressure therapy was applied after surgery; patients were monitored for 12 months. No infra or postoperative complications were observed. Data on scar skin quality (Vancouver scar scale), rate of mobility recovery, and graft contraction were recorded; as well as morphological analyses at light microscopical level. Improvement in mobility and skin quality were demonstrated along with graft contraction, in all patients. The double layer template showed the best performance in retraction rate, skin quality and mobility recovery. The subepidermal newly-formed connective tissue showed no histoarchitectural differences between the templates. The double layer template was not absorbed up to 12 months after placement. (C) 2019 Elsevier Ltd and ISBI. All rights reserved.
C1 [Molina Vana, Luiz Philipe; Gemperli, Rolf; Alonso, Nivaldo] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Sao Paulo, Brazil.
   [Molina Vana, Luiz Philipe; Gemperli, Rolf; Alonso, Nivaldo] Div Cirurgia Plast & Queimaduras, Sao Paulo, Brazil.
   [Battlehner, Claudia Naves; Ferreira, Marcelo Alves; Caldini, Elia Garcia] Univ Sao Paulo, Fac Med FMUSP, Dept Patol, Sao Paulo, Brazil.
   [Battlehner, Claudia Naves; Ferreira, Marcelo Alves; Caldini, Elia Garcia] Lab Biol Celular, Dept Patol, LIM59, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Vana, LPM (通讯作者)，Rua Batataes 460 Cj11, BR-01423010 Sao Paulo, Brazil.
EM philipe@uol.com.br
RI ; Caldini, Elia Garcia/F-1105-2011; alonso, nivaldo/AAB-4570-2021;
   Ferreira, Marcelo/AAC-4009-2022; Gemperli, Rolf/C-9116-2012
OI Vana, Luiz Philipe/0000-0002-7305-8399; Caldini, Elia
   Garcia/0000-0001-5322-3812; alonso, nivaldo/0000-0003-1532-9610;
   Ferreira, Marcelo/0000-0003-4181-760X; 
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NR 59
TC 28
Z9 35
U1 2
U2 13
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAY
PY 2020
VL 46
IS 3
BP 596
EP 608
DI 10.1016/j.burns.2019.09.005
PG 13
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA LK2RF
UT WOS:000530707800012
PM 31645293
DA 2026-07-24
ER
PT J
AU Mahendran, B
   Rossi, B
   Coleman, M
   Smolarek, S
AF Mahendran, B.
   Rossi, B.
   Coleman, M.
   Smolarek, S.
TI The use of Endo-SPONGE(R) in rectal anastomotic leaks: a systematic
   review
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Review
DE Endo-SPONGE; Vacuum therapy; Rectal cancer; Anastomotic leak
ID VACUUM-ASSISTED CLOSURE; POUCH-ANAL ANASTOMOSIS; ENDO-SPONGE TREATMENT;
   THERAPY; DRAINAGE; MANAGEMENT; RESECTION; SURGERY; EXPERIENCE; ABSCESS
AB Background The aim of this study was to assess the efficacy of an endoluminal vacuum device (Endo-SPONGE(R)) in the treatment of rectal anastomotic leaks. Methods All studies looking at endoluminal vacuum therapy with Endo-SPONGE(R) in the treatment of rectal anastomotic leaks were included. A comprehensive search was conducted as per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Primary outcome was defined as the rate of total anastomotic salvage, with secondary outcomes including rate of ileostomy closure, additional transrectal closures and functional outcomes Results Sixteen studies met the inclusion criteria. There was a significant publication bias (z = 3.53, p = 0.0004). Two hundred sixty-six patients were identified. The median treatment failure rate was 11.8% (range 0-44%), with random effects model of 0.17 (95% CI 0.11-0.22). There was improvement with early therapy start (OR 3.48) and negative correlation with neoadjuvant radiotherapy (OR 0.56). Fifty-one percent of all diverting stomas were closed at the end of treatment period and 12.8% of patients required an additional trans-rectal closure of the abscess cavity. Conclusions Endo-SPONGE(R) seems to be a useful method of rectal anastomotic leak treatment in selected group of patients; however, the quality of available data is poor and it is impossible to draw a final conclusion. There is unexpected high rate of permanent ileostomy. There is a need for further assessment of this therapy with well-designed randomised or cohort studies.
C1 [Mahendran, B.; Rossi, B.; Coleman, M.; Smolarek, S.] Univ Hosp Plymouth NHS Trust, Dept Colorectal Surg, Derriford Hosp, Derriford Rd, Plymouth PL6 8DH, Devon, England.
C3 Derriford Hospital
RP Mahendran, B (通讯作者)，Univ Hosp Plymouth NHS Trust, Dept Colorectal Surg, Derriford Hosp, Derriford Rd, Plymouth PL6 8DH, Devon, England.
EM Balaji.mahendran@nhs.net
CR Arezzo A, 2015, DIGEST LIVER DIS, V47, P342, DOI 10.1016/j.dld.2014.12.003
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NR 29
TC 18
Z9 20
U1 0
U2 3
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD JUL
PY 2020
VL 24
IS 7
BP 685
EP 694
DI 10.1007/s10151-020-02200-1
EA MAY 2020
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA LY6JI
UT WOS:000530772000001
PM 32377984
DA 2026-07-24
ER
PT J
AU Poillucci, G
   Podda, M
   Russo, G
   Perri, SG
   Ipri, D
   Manetti, G
   Lolli, MG
   De Angelis, R
AF Poillucci, Gaetano
   Podda, Mauro
   Russo, Giulia
   Perri, Sergio Gaetano
   Ipri, Domenico
   Manetti, Gabriele
   Lolli, Maria Giulia
   De Angelis, Renato
TI Open abdomen closure methods for severe abdominal sepsis: a
   retrospective cohort study
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Open abdomen; Abdominal sepsis; Bogota-Bag; Negative pressure wound
   therapy; Emergency surgery
ID PRIMARY FASCIAL CLOSURE; DAMAGE CONTROL; COMPARTMENT SYNDROME; OPEN
   MANAGEMENT; SEPTIC SHOCK; VACUUM; OPERATION; PRESSURE; FISTULAS
AB Purpose The open abdomen (OA) procedure as part of damage control surgery represents a significant surgical advance in severe intra-abdominal infections. Major techniques used for OA are negative pressure wound therapy (NPWT) and non-NPWT. The aim of this retrospective study is to evaluate the effects of different abdominal closure methods and their outcomes in patients presenting with abdominal sepsis treated with OA. Materials and methods We retrospectively analyzed clinical outcomes of patients affected by severe intra-abdominal sepsis treated with OA. Demographic features, mortality prediction score, abdominal closure methods, length of hospital stay, complications and mortality rates of patients were determined and compared. Results This study included 106 patients, of whom 77 underwent OA with NPWT and 29 with non-NPWT. OA duration was longer in NPWT patients (p = 0.007). In-hospital mortality rates in NPWT and in non-NPWT patients were 40.3% and 51.7%, respectively (p = 0.126), with an overall 30-day mortality rate of 18.2% and 51.7%, respectively (p = 0.0002). After emergency colorectal surgery, patients who underwent OA with NPWT had a lower rate of colostomy (p = 0.025). Conclusions NPWT is the best temporary abdominal closure technique to decrease mortality and colostomy rates in patients managed with OA for severe intra-abdominal infections.
C1 [Poillucci, Gaetano] Policlin Univ Umberto I, Dept Gen & Specialized Surg Paride Stefanini, Viale Policlin 155, Rome 00161, Italy.
   [Podda, Mauro] Univ Cagliari, Policlin Univ D Casula, Dept Gen Emergency & Minimally Invas Surg, Monserrato, Italy.
   [Russo, Giulia] San Camillo De Lellis Hosp, Dept Gen Surg, Rieti, Italy.
   [Perri, Sergio Gaetano; Ipri, Domenico; Manetti, Gabriele; Lolli, Maria Giulia; De Angelis, Renato] San Giovanni Addolorata Hosp, Dept Gen Surg, Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome; University
   of Cagliari; Azienda Ospedaliera San Giovanni Addolorata
RP Poillucci, G (通讯作者)，Policlin Univ Umberto I, Dept Gen & Specialized Surg Paride Stefanini, Viale Policlin 155, Rome 00161, Italy.
EM gaetano.poillucci@gmail.com
RI ; Podda, Mauro/AAI-1393-2019
OI Poillucci, Gaetano/0000-0002-3961-1904; Podda, Mauro/0000-0001-9941-0883
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NR 35
TC 12
Z9 16
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD DEC
PY 2021
VL 47
IS 6
SI SI
BP 1819
EP 1825
DI 10.1007/s00068-020-01379-0
EA MAY 2020
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA XE8ZQ
UT WOS:000530776400001
PM 32377924
DA 2026-07-24
ER
PT J
AU Sezai, A
   Unosawa, S
   Taoka, M
   Osaka, S
   Kitazumi, Y
   Suzuki, K
   Nakai, T
   Tanaka, M
AF Sezai, Akira
   Unosawa, Satoshi
   Taoka, Makoto
   Osaka, Shunji
   Kitazumi, Yoshiki
   Suzuki, Keito
   Nakai, Toshiko
   Tanaka, Masashi
TI New Treatment for Driveline Infection Following Implantation of a
   Ventricular Assist Device
SO HEART SURGERY FORUM
LA English
DT Article
AB In patients with an implantable ventricular assist device (VAD), driveline infection (DLI) is a challenging complication. Once DLI occurs, it may lead to pump contamination and/or septicemia, which means that early treatment is essential. We hereby report our initial experiences of a mechanically-powered portable negative pressure wound therapy system (Smart Negative Pressure: SNaPTM) to treat DLI at an outpatient clinic.
C1 [Sezai, Akira; Unosawa, Satoshi; Taoka, Makoto; Osaka, Shunji; Kitazumi, Yoshiki; Suzuki, Keito; Nakai, Toshiko; Tanaka, Masashi] Nihon Univ, Sch Med, Dept Cardiol, Dept Cardiovasc Surg, Tokyo, Japan.
C3 Nihon University
RP Sezai, A (通讯作者)，Nihon Univ, Sch Med, Dept Cardiovasc Surg, Itabashi Ku, 30-1 Oyaguchi Kamimachi, Tokyo 1738610, Japan.
EM asezai.med@gmail.com
CR Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
   Cook JL, 2017, CIRCULATION, V135, pE1145, DOI 10.1161/CIR.0000000000000507
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   Yoshitake S, 2018, J CARDIOL, V72, P363, DOI 10.1016/j.jjcc.2018.04.003
NR 9
TC 3
Z9 7
U1 0
U2 0
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PY 2020
VL 23
IS 2
BP E132
EP E134
DI 10.1532/hsf.2899
PG 3
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA LK7TC
UT WOS:000531063500009
PM 32364899
OA gold
DA 2026-07-24
ER
PT J
AU Al-Ebrahim, KE
AF Al-Ebrahim, Khaled Ebrahim
TI Management of Deep Sternal Wound Infection: Complete Sternal
   Osteomyelitis
SO HEART SURGERY FORUM
LA English
DT Article
ID RISK-FACTORS; PREVENTION
AB Deep sternal wound infection (DSWI) after cardiac surgery is a challenging complication that affects the outcome of surgery. The worst type of DSWI is mediastinitis and sternal osteomyelitis, which dramatically increase morbidity, mortality, and cost of care. This case report describes successful treatment of sternal osteomyelitis after open heart surgery with combined negative pressure wound therapy and rectus abdominis flap. This combination of negative pressure wound therapy with rectus abdominis flap in treating sternal osteomyelitis after open cardiac surgery is not well studied.
C1 [Al-Ebrahim, Khaled Ebrahim] King Abdulaziz Univ, Dept Surg, Jeddah, Saudi Arabia.
C3 King Abdulaziz University
RP Al-Ebrahim, KE (通讯作者)，King Abdulaziz Univ Hosp, Dept Surg, POB 80215, Jeddah 21589, Saudi Arabia.
EM dr.k.ebrahim@gmail.com
FU Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah
   [D1441-523-140]; DSR
FX This work was funded by the Deanship of Scientific Research (DSR), King
   Abdulaziz University, Jeddah, under grant no. D1441-523-140. The author
   acknowledges with thanks DSR technical and financial support.
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   Malmsjö M, 2009, WOUND REPAIR REGEN, V17, P200, DOI 10.1111/j.1524-475X.2009.00461.x
   Schiraldi L, 2019, ARCH PLAST SURG-APS, V46, P291, DOI 10.5999/aps.2018.01151
   Sears ED, 2016, WORLD J SURG, V40, P2673, DOI 10.1007/s00268-016-3598-7
   Tewarie L, 2019, ANN THORAC CARDIOVAS, V25, P102, DOI 10.5761/atcs.oa.18-00115
   Weinand C, 2013, EUR J PLAST SURG, V36, P95, DOI 10.1007/s00238-012-0768-1
   Yusuf E, 2018, INFECT DRUG RESIST, V11, P961, DOI 10.2147/IDR.S130172
   Zahiri HR, 2012, ANN PLAS SURG, V69, P439, DOI 10.1097/SAP.0b013e318231d1ef
NR 16
TC 6
Z9 7
U1 0
U2 2
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PY 2020
VL 23
IS 3
BP E281
EP E284
DI 10.1532/hsf.2805
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA LK7TO
UT WOS:000531064700005
PM 32524983
OA gold
DA 2026-07-24
ER
PT J
AU Addeo, P
   Noblet, V
   Naegel, B
   Bachellier, P
AF Addeo, Pietro
   Noblet, Vincent
   Naegel, Benoit
   Bachellier, Philippe
TI Large-for-Size Orthotopic Liver Transplantation: a Systematic Review of
   Definitions, Outcomes, and Solutions
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Review
DE Anthropometrics; Graft reduction; Large-for-size; Liver transplantation;
   Mismatch; Negative pressure wound therapy
ID BODY-WEIGHT RATIO; DECEASED DONOR; GRAFT WEIGHT; MODEL; PARAMETERS;
   RECIPIENTS; CLOSURE; IMPACT
AB Background We systematically reviewed the literature on definitions and outcomes of large-for-size (LFS) syndrome in orthotopic liver transplantation (LT). Methods This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Cochrane Library, PubMed, and Embase were searched (January 1990-January 2019) for studies reporting LFS in LT. Primary outcomes were definitions and mortality of LFS LT. Results Eleven studies reporting patients with LFS LT were identified. Four different formulas (graft-to-recipient weight ratio (GRWR), body surface area index (BSAi), donor standardized total liver volume (sTLV)-to-recipient sTLV ratio, and graft weight/right anteroposterior distance (RAP) ratio) with their critical thresholds were found. There were 81 patients (54% women) with a median weight and height of 62.5 kg (range, 40-105 kg) and 165 cm (range, 145-180 cm). The median graft weight was 1772 g (range, 1290-2400 g), and the median GWRW was 2.77% (range, 2.1-4.00%). Graft venous outflow obstruction was described in seven patients (8.6%). At the time of LT, fascial closure was not achieved in 24 patients (29.6%) and the graft size was reduced by a liver resection in three patients (3.7%). Thirteen deaths (16%) were reported in the first 90 postoperative days with two patients undergoing re-transplant. Conclusions LFS LT remains heterogeneously defined but characterized by high mortality rates despite the use of tailored surgical solutions (graft reduction and open abdomen). A composite definition is proposed in order to better describe LFS clinical syndrome.
C1 [Addeo, Pietro; Bachellier, Philippe] Univ Strasbourg, Hepatopancreatobiliary Surg & Liver Transplantat, Pole Pathol Digest Hepat & Transplantat, Hop Hautepierre,Hop Univ Strasbourg, 1 Ave Moliere, F-67098 Strasbourg, France.
   [Addeo, Pietro; Noblet, Vincent; Naegel, Benoit] Univ Strasbourg, ICube, CNRS UMR 7357, Illkirch Graffenstaden, France.
C3 CHU Strasbourg; Universites de Strasbourg Etablissements Associes;
   Universite de Strasbourg; Universites de Strasbourg Etablissements
   Associes; Universite de Strasbourg; Centre National de la Recherche
   Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences
   (INSIS)
RP Addeo, P (通讯作者)，Univ Strasbourg, Hepatopancreatobiliary Surg & Liver Transplantat, Pole Pathol Digest Hepat & Transplantat, Hop Hautepierre,Hop Univ Strasbourg, 1 Ave Moliere, F-67098 Strasbourg, France.; Addeo, P (通讯作者)，Univ Strasbourg, ICube, CNRS UMR 7357, Illkirch Graffenstaden, France.
EM pietrofrancesco.addeo@chru-strasbourg.fr
RI ADDEO, Pietro/ADD-9196-2022; Noblet, Vincent/ABE-4264-2020
OI ADDEO, Pietro/0000-0003-0046-7973
CR Allard MA, 2017, LIVER TRANSPLANT, V23, P1294, DOI 10.1002/lt.24835
   Allard MA, 2017, HPB, V19, P338, DOI 10.1016/j.hpb.2016.11.012
   Brustia R, 2015, CLIN RES HEPATOL GAS, V39, P552, DOI 10.1016/j.clinre.2015.02.009
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   Olthoff KM, 2010, LIVER TRANSPLANT, V16, P943, DOI 10.1002/lt.22091
   Moreira DDAR, 2014, J SURG RES, V189, P313, DOI 10.1016/j.jss.2014.03.018
   Tschuor C, 2019, J HEPATOL
   XU HS, 1994, ANN SURG, V219, P46, DOI 10.1097/00000658-199401000-00008
NR 24
TC 29
Z9 35
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD MAY
PY 2020
VL 24
IS 5
BP 1192
EP 1200
DI 10.1007/s11605-019-04505-5
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA LK9EE
UT WOS:000531159900028
PM 31919740
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Johnson, AR Jr
   Mooshol, D
   Thakar, V
   Williams, M
AF Johnson, Alton R., Jr.
   Mooshol, Danielle
   Thakar, Vikram
   Williams, Marie
TI Surgical Management of Idiopathic Ulcerative Calcinosis Cutis in the
   Lower Extremity: A Case Report
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE acellular dermal matrix; calcium deposits; debridement; excision
AB The purpose of this case study is to describe the surgical treatment of idiopathic ulcerative cutaneous calcinosis or calcinosis cutis of the lower extremity. A 77-year-old Latin American female who reported no significant past medical history presented to our hospital's emergency department from her home complaining of worsening right lower extremity erythema, edema, increased temperature, and pain. It was noted that the patient presented with multiple cutaneous calcified nodules to bilateral lower extremities, which she stated has been present for approximately 40 years. At the time of evaluation, 1 of the nodules on the lateral aspect of the right lower extremity ulcerated and became infected with unknown etiology, which lead to cellulitis of this limb. Radiographic imaging studies of the bilateral lower extremities showed extensive sheetlike soft tissue calcification overlying the middle to distal lower extremities. Serology reports showed the patient was positive for rheumatoid factor, antinuclear antibodies, SS-A/Ro antibody, and SS-B/La antibody. Because of the evidence of frank purulence and cellulitic changes to the infected nodule, the patient was taken to surgery the following day for sharp debridement and biopsy of the site. Postoperatively, there were minimal signs of improved healing to the wound base, although there was evidence of decreased erythema and edema to the extremity after the initial debridement and biopsy. Four days after the initial surgical invention, the patient was taken for a second operative procedure, which included a wide excisional biopsy with application of acellular dermal matrix and negative-pressure therapy. It was during this secondary debridement that further calcified deposits were encountered and specimens were submitted to pathology. Pathologic examination diagnosed the submitted specimen as cutaneous calcinosis. At this time, the patient is currently undergoing local wound care of the soft tissue deficient to her right lower extremity with the assistance of negative-pressure wound therapy with biweekly clinical follow-up. (C) 2019 The Author(s). This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)
C1 [Johnson, Alton R., Jr.; Mooshol, Danielle; Thakar, Vikram] Aventura Hosp & Med Ctr, 20900 Biscayne Blvd, Aventura, FL 33180 USA.
   [Williams, Marie] Aventura Hosp & Med Ctr, Podiatr Surg, Aventura, FL 33180 USA.
RP Johnson, AR Jr (通讯作者)，Aventura Hosp & Med Ctr, 20900 Biscayne Blvd, Aventura, FL 33180 USA.
EM alton.johnsondpm@gmail.com
OI Johnson, Alton/0000-0001-9606-1147
CR Dhar Dinesh, 2013, Oman Med J, V28, P131, DOI 10.5001/omj.2013.34
   Fairley JA, 2012, DERMATOLOGY GEN MED
   Lobo IMM, 2008, DERMATOL ONLINE J, V14
   ROTHE MJ, 1990, ARCH DERMATOL, V126, P1060, DOI 10.1001/archderm.126.8.1060
NR 4
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAY-JUN
PY 2020
VL 59
IS 3
BP 603
EP 607
DI 10.1053/j.jfas.2019.09.032
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA LL4WW
UT WOS:000531558700015
PM 31732275
OA hybrid
DA 2026-07-24
ER
PT J
AU Kim, JH
   Lee, DH
AF Kim, Jun-Ho
   Lee, Dae-Hee
TI Are high-risk patient and revision arthroplasty effective indications
   for closed-incisional negative-pressure wound therapy after total hip or
   knee arthroplasty? A systematic review and meta-analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE closed-incisional negative-pressure wound therapy; surgical site
   infection; total hip arthroplasty; total knee arthroplasty; wound
   complication
ID PERIPROSTHETIC JOINT INFECTION; SURGICAL-SITE INFECTIONS; POSTOPERATIVE
   MORTALITY; MEDICARE PATIENTS; MANAGEMENT; DRESSINGS; CALCULATOR; RATES;
   COMPLICATIONS; READMISSION
AB To determine the effective indications of closed-incisional negative-pressure wound therapy (ciNPWT) following total hip or knee arthroplasty, this systematic review and meta-analysis was conducted. The systematic search was performed on MEDLINE, Embase, and Cochrane Library, and 11 studies were included. The studies comparing between ciNPWT and conventional dressings were categorised into following subgroups based on patient risk and revision procedures: routine vs high-risk patient; primary vs revision arthroplasty. Pooled estimates were calculated for wound complication and surgical site infection (SSI) rates in the subgroup analyses using Review Manager. In high-risk patients, the overall rates of wound complication (odds ratio [OR] = 0.38; 95% confidence interval [CI] 0.15-0.93; P = .030) and SSI (OR = 0.24; 95% CI = 0.09-0.64; P = .005) were significantly lower in the ciNPWT; however, there were no differences in routine patients. In cases involving revision arthroplasties, the overall rates of wound complication (OR = 0.33; 95% CI = 0.18-0.62; P < .001) and SSI (OR = 0.26; 95% CI = 0.11-0.66; P = .004) were significantly lower in the ciNPWT; however, there were no differences in cases involving primary arthroplasties. In summary, ciNPWT showed a positive effect in decreasing the rates of wound complication and SSI in high-risk patients and in revision arthroplasties.
C1 [Kim, Jun-Ho] Seoul Med Ctr, Dept Orthoped Surg, Seoul, South Korea.
   [Lee, Dae-Hee] Sungkyunkwan Univ, Sch Med, Dept Orthopaed Surg, Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea.
C3 Seoul Medical Center; Sungkyunkwan University (SKKU); Samsung Medical
   Center
RP Lee, DH (通讯作者)，Sungkyunkwan Univ, Sch Med, Dept Orthopaed Surg, Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea.
EM eoak22@empal.com
RI lee, dae/I-9390-2017
CR AlBuhairan B, 2008, J BONE JOINT SURG BR, V90B, P915, DOI 10.1302/0301-620X.90B7.20498
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NR 50
TC 23
Z9 23
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1310
EP 1322
DI 10.1111/iwj.13393
EA MAY 2020
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000532562400001
PM 32406175
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Naylor, RM
   Gilder, HE
   Gupta, N
   Hydrick, TC
   Labott, JR
   Mauler, DJ
   Trentadue, TP
   Ghislain, B
   Elder, BD
   Fogelson, JL
AF Naylor, Ryan M.
   Gilder, Hannah E.
   Gupta, Nikita
   Hydrick, Thomas C.
   Labott, Joshua R.
   Mauler, David J.
   Trentadue, Taylor P.
   Ghislain, Brandon
   Elder, Benjamin D.
   Fogelson, Jeremy L.
TI Effects of Negative Pressure Wound Therapy on Wound Dehiscence and
   Surgical Site Infection Following Instrumented Spinal Fusion Surgery-A
   Single Surgeon's Experience
SO WORLD NEUROSURGERY
LA English
DT Article
DE NPWT; Prevention; Spine fusion; Surgical wound complications
ID VACUUM ASSISTED CLOSURE; LUMBAR FUSION; MANAGEMENT; COMPLICATIONS;
   MECHANISMS; INCISION; RISK
AB BACKGROUND: Incisional negative pressure wound therapy (NPWT) is used in many surgical specialties to prevent postoperative dehiscence and surgical site infections (SSIs). However, little is known about the role of incisional NPWT in spine fusion surgery. Therefore, we sought to report a single surgeon's experience using incisional NPWT and describe its effects on dehiscence and SSIs after instrumented spine surgery.
   METHODS: We compared rates of hospital readmission and return to the operating room for dehiscence and SSIs in a consecutive series of patients who underwent spinal fusion surgery with or without NPWT from 2015 to 2018.
   RESULTS: A total of 393 patients without and 76 patients with NPWTwere included for analysis. Half way through the data collection period, all patients who underwent anterior lumbar fusion received NPWT. Three of 15 (20.0%) of nonNPWT patients who underwent anterior lumbar fusion had dehiscence or SSI compared with zero of 23 (0.0%) of NPWT patients (P = 0.01). NPWT for posterior surgeries was used on a case-by-case basis using risk factors that contribute to SSIs and dehiscence. NPWT patients had higher rates of spinal neoplasia (0.5% vs. 11.3%, P < 0.0001), osteomyelitis/diskitis (1.3% vs. 7.5%, P = 0.02), durotomy (14.9% vs. 28.6%, P = 0.007), revision surgery (32.2% vs. 59.6%, P = 0.0001), and longer fusion constructs (7 vs. 11 levels, P < 0.0001) but had similar rates of dehiscence and SSIs as non-NPWT patients (5.6% vs. 5.7%, P = 0.98).
   CONCLUSIONS: NPWT decreases dehiscence and SSIs in patients undergoing lumbar fusion through an anterior approach. When preferentially used in patients at high risk for postoperative wound complications, NPWT prevents increased rates of dehiscence and SSI.
C1 [Naylor, Ryan M.; Gilder, Hannah E.; Elder, Benjamin D.; Fogelson, Jeremy L.] Mayo Clin, Dept Neurol Surg, Rochester, MN 55905 USA.
   [Labott, Joshua R.; Trentadue, Taylor P.; Ghislain, Brandon] Mayo Clin, Alix Sch Med, Rochester, MN USA.
   [Trentadue, Taylor P.] Mayo Clin, Med Scientist Training Program, Rochester, MN USA.
   [Elder, Benjamin D.; Fogelson, Jeremy L.] Mayo Clin, Dept Orthoped Surg, Rochester, MN 55905 USA.
   [Elder, Benjamin D.] Mayo Clin, Dept Biomed Engn, Rochester, MN USA.
   [Gupta, Nikita; Hydrick, Thomas C.; Mauler, David J.] Mayo Clin, Alix Sch Med, Scottsdale, AZ USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo
   Clinic; Mayo Clinic Phoenix
RP Fogelson, JL (通讯作者)，Mayo Clin, Dept Neurol Surg, Rochester, MN 55905 USA.; Fogelson, JL (通讯作者)，Mayo Clin, Dept Orthoped Surg, Rochester, MN 55905 USA.
EM fogelson.jeremy@mayo.edu
RI Naylor, Ryan/AFP-1072-2022
OI GUPTA, NIKITA/0000-0003-3098-6598; Mauler, David/0000-0003-0247-5854;
   Trentadue, Taylor/0000-0002-0390-3243
FU National Institute of General Medical Sciences [T32GM065841] Funding
   Source: NIH RePORTER; NIGMS NIH HHS [T32 GM065841] Funding Source:
   Medline
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NR 28
TC 22
Z9 25
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD MAY
PY 2020
VL 137
BP E257
EP E262
DI 10.1016/j.wneu.2020.01.152
PG 6
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA LN1TU
UT WOS:000532728700012
PM 32004742
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Baek, SO
   Shin, J
   Song, JK
   Lee, JY
AF Baek, Sang Oon
   Shin, Jeonghwan
   Song, Jong Keun
   Lee, Jun Yong
TI Multimodal Conservative Treatment of Complicated Open Wound After Total
   Knee Replacement Arthroplasty in Patients With Comorbidities
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE dermatotraction; negative pressure wound therapy; total knee replacement
   arthroplasty; rehabilitation; wound healing
ID VACUUM-ASSISTED CLOSURE; TOTAL HIP; SHOELACE TECHNIQUE;
   DIABETES-MELLITUS; OPERATIVE TIME; RISK-FACTOR; REVISION; OUTCOMES;
   SMOKING; SKIN
AB Total knee replacement arthroplasty is a common procedure and postoperative wound complications are sometimes inevitable. Although invasive reconstructive surgery may be an option for nonhealed wounds, such procedures can limit early rehabilitation, adversely affecting the range of joint motion. Patients can achieve a wider range of motion if they undergo early rehabilitation with a conservative approach. From 2015 to 2017, 5 patients with comorbidities who underwent total knee replacement arthroplasty were referred to the reconstructive surgery department for nonhealed open wounds. Depending on their comorbidities and conditions, the patients underwent negative-pressure wound therapy based on multimodal conservative treatment. During the treatment, the patients continued rehabilitation. In the 5 patients, the mean duration of complete wound healing was 65.2 days (range = 57-81), during which all open wounds were well healed. For final wound closure, the patients underwent skin grafting, dermatotraction, or collagen dressing. Four patients achieved ranges of joint motion over 100 degrees after treatment. We believe that early coverage is important for open wounds. For complicated open wounds after total knee replacement arthroplasty in patients with comorbidities, less invasive multimodal treatment along with early rehabilitation may be more effective to achieve adequate final range of joint motion.
C1 [Baek, Sang Oon; Shin, Jeonghwan; Song, Jong Keun; Lee, Jun Yong] Catholic Univ Korea, Dept Plast & Reconstruct Surg, Coll Med, Seoul, South Korea.
C3 Catholic University of Korea
RP Lee, JY (通讯作者)，Catholic Univ Korea, Dept Plast & Reconstruct Surg, Incheon St Marys Hosp, Coll Med, 56 Dongsu Ro, Incheon 21431, South Korea.
EM ps.jylee@catholic.ac.kr
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NR 41
TC 3
Z9 4
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2021
VL 20
IS 4
BP 347
EP 354
AR 1534734620919315
DI 10.1177/1534734620919315
EA MAY 2020
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA WN7JW
UT WOS:000532787300001
PM 32380929
DA 2026-07-24
ER
PT J
AU Fang, JJ
   Li, PF
   Wu, JJ
   Zhou, HY
   Xie, LP
   Lu, H
AF Fang, Jia-Jie
   Li, Peng-Fei
   Wu, Jia-Jun
   Zhou, Hai-Ying
   Xie, Li-Ping
   Lu, Hui
TI Reconstruction of massive skin avulsion of the scrota and penis by
   combined application of dermal regeneration template (Pelnac) and
   split-thickness skin graft with vacuum-assisted closure: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Artificial dermis; Dermal regeneration template; Massive skin defect;
   Penoscrotal defect; Split-thickness skin graft; Case report
ID COVERAGE; DEFECTS; TRAUMA
AB BACKGROUND Although skin avulsions to male external genitalia are rare, they can be both physically and psychologically traumatic. Thus, the necessity for judicious management poses significant challenges to surgeons in order to avoid potential permanent disabilities. We report a case of massive penoscrotal skin avulsion and a composite graft was creatively applied to cover the defect which achieved good results. We believe that this case is of great reference value for fellow surgeons.
   CASE SUMMARY A 52-year-old male presented with massive traumatic avulsion of the penile and scrotal skin following mishandling of an electric drill. The avulsed skin was missing. The patient was diagnosed with massive skin avulsion of external genitalia. Following initial complete debridement of devitalized or infected tissues, Pelnac dermal substitute was secured to the defect with the assistance of negative-pressure wound closure. In the final step, the silicone layer of Pelnac was removed and a split-thickness skin graft was applied. The defect had healed at the two-month follow-up. The patient now has normal erections and satisfactory sexual function.
   CONCLUSION Our experience with this wound repair demonstrated that the combination of a dermal regeneration template and a split-thickness skin graft with vacuum-assisted closure is a safe, well-tolerated and efficient solution for the reconstruction of massive penoscrotal skin defects.
C1 [Fang, Jia-Jie; Xie, Li-Ping] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Urol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
   [Li, Peng-Fei] Zhejiang Univ, Affiliated Hosp 1, Dept Plast & Aesthet Ctr, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China.
   [Wu, Jia-Jun] Xingyan Aesthet Clin, Hangzhou 310003, Zhejiang, Peoples R China.
   [Zhou, Hai-Ying; Lu, Hui] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Orthoped, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University
RP Xie, LP (通讯作者)，Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Urol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM xielp@zju.edu.cn
OI lu, hui/0000-0002-5921-1043
FU National Natural Science Foundation of China [81702135]; Zhejiang
   Traditional Chinese Medicine Research Program [2016ZA124, 2017ZB057];
   Zhejiang Medicine and Hygiene Research Program [2016KYB101, 2015KYA100];
   Zhejiang Medical Association Clinical Scientific Research Program
   [2013ZYC-A19, 2015ZYC-A12]
FX Supported by National Natural Science Foundation of China, No. 81702135;
   Zhejiang Traditional Chinese Medicine Research Program, No. 2016ZA124
   and No. 2017ZB057; Zhejiang Medicine and Hygiene Research Program, No.
   2016KYB101 and No. 2015KYA100; Zhejiang Medical Association Clinical
   Scientific Research Program, No. 2013ZYC-A19 and No. 2015ZYC-A12.
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NR 21
TC 11
Z9 11
U1 0
U2 8
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD DEC 26
PY 2019
VL 7
IS 24
BP 4349
EP 4354
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LO4AS
UT WOS:000533572200021
PM 31911918
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Ge, S
   Ngaage, LM
   Orbay, H
   Silverman, RP
   Rasko, YM
   Rada, EM
AF Ge, Shealinne
   Ngaage, Ledibabari M.
   Orbay, Hakan
   Silverman, Ronald P.
   Rasko, Yvonne M.
   Rada, Erin M.
TI Surgical Management of Pediatric Hidradenitis Suppurativa A Case Series
   and Review of the Literature
SO ANNALS OF PLASTIC SURGERY
LA English
DT Review
DE hidradenitis suppurativa; surgical management; child; negative-pressure
   wound therapy; recurrence
ID RISK-FACTORS; RECURRENCE; OUTCOMES; CHILDREN; THERAPY
AB Background
   Hidradenitis suppurativa (HS) is a chronic and physically debilitating condition. Achieving long-term remission is difficult and sometimes remains elusive despite use of multiple pharmacological agents. However, surgery remains underused in the pediatric population.
   Methods
   We conducted a retrospective review for a 10-year period of all patients younger than 18 years who had undergone surgery for HS at a tertiary university hospital. In addition, we performed a literature review for English language articles related to the surgical management of pediatric HS patients.
   Results
   Eleven patients with a total of 23 operative sites were included in the study. The cohort was predominantly female (10:1) with an average age of 15.4 years and mean body mass index 31.9 kg/m(2). Lesion size ranged from 12.6 to 400 cm(2). Overall complication rate was 87% with a 7% reoperation rate to manage complications. Remission was achieved after a single procedure in 57% of sites. Three articles met our inclusion criteria for the literature review.
   Conclusions
   Our article adds to the sparse literature and represents the largest study on surgical management of pediatric HS patients. Although surgery is not without its challenges, it presents a safe option and for pediatric HS patients with extensive scar or sinus tract formation.
C1 [Ge, Shealinne; Ngaage, Ledibabari M.; Silverman, Ronald P.; Rasko, Yvonne M.; Rada, Erin M.] Univ Maryland, Sch Med, Div Plast Surg, 22 S Greene St, Baltimore, MD 21230 USA.
   [Ge, Shealinne; Ngaage, Ledibabari M.; Orbay, Hakan; Silverman, Ronald P.; Rasko, Yvonne M.; Rada, Erin M.] Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21230 USA.
   [Silverman, Ronald P.] Acel Corp, San Antonio, TX USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore
RP Rada, EM (通讯作者)，Univ Maryland, Sch Med, Div Plast Surg, 22 S Greene St, Baltimore, MD 21230 USA.
EM erada@som.umaryland.edu
RI ; Silverman, Ronald/A-5155-2018
OI Ngaage, Ledibabari/0000-0001-5802-779X; 
CR [Anonymous], 1998, Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report
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NR 26
TC 14
Z9 16
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2020
VL 84
IS 5
BP 570
EP 574
DI 10.1097/SAP.0000000000002195
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LP5IU
UT WOS:000534352000020
PM 31913903
DA 2026-07-24
ER
PT J
AU Loh, ML
   Goh, BKL
   Kong, Y
   Varughese, G
   Ng, JL
   Lo, ZWJ
   Pek, CH
AF Loh, Mei Ling
   Goh, Benjamin K. L.
   Kong, Yuan
   Varughese, George
   Ng, Jia Lin
   Lo, Zhiwen J.
   Pek, Chong Han
TI Combination therapy of oxidised regenerated cellulose/collagen/silver
   dressings with negative pressure wound therapy for coverage of exposed
   critical structures in complex lower-extremity wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE cellulose; oxidised; collagen; lower extremity; negative pressure wound
   therapy; wounds and healing
ID MANAGEMENT; MATRIX; REPAIR
AB Complex wounds with exposed critical structures such as tendon and bone are a conundrum in wound management, especially in the setting where the patient is not a suitable candidate for flap surgery. While the individual use of negative pressure wound therapy (NPWT) and oxidised regenerated cellulose (ORC)/collagen/silver (PROMOGRAN PRISMA) dressing has been described in the literature, there are little data on the efficacy of their combined use. In this study, we describe a novel technique of combining the use of NPWT and ORC/collagen/silver dressings to manage complex wound beds as an alternative management option for patients not suitable for reconstructive flap surgery. This technique was performed in a series of 37 patients with complex lower-extremity wounds that were not healing with conventional NPWT alone. All patients had open wounds with exposed critical structures that were difficult to manage, such as exposed tendon, bone, deep crevices, and joint. Successful coverage of exposed critical structures was achieved in 89% of patients, and coverage was achieved within 28 days of combination therapy in 82% of these patients, without any complications. The novel technique of combining ORC/collagen/silver dressing and NPWT provides a useful option in the armamentarium of a reconstructive surgeon dealing with difficult complex lower-extremity wounds.
C1 [Loh, Mei Ling; Goh, Benjamin K. L.; Kong, Yuan; Varughese, George; Pek, Chong Han] Khoo Teck Puat Hosp, Dept Gen Surg Plast Reconstruct & Aesthet Surg Se, 90 Yishun Cent, Singapore 768828, Singapore.
   [Ng, Jia Lin] Khoo Teck Puat Hosp, Dept Podiatry, Singapore, Singapore.
   [Lo, Zhiwen J.] Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, Singapore, Singapore.
C3 Tan Tock Seng Hospital
RP Pek, CH (通讯作者)，Khoo Teck Puat Hosp, Dept Gen Surg Plast Reconstruct & Aesthet Surg Se, 90 Yishun Cent, Singapore 768828, Singapore.
EM pek.chong.han@ktph.com.sg
RI ; Pek, Chong Han/AAJ-2977-2020
OI LO, ZHIWEN JOSEPH/0000-0003-2289-5266; Pek, Chong
   Han/0000-0002-1354-9399; Loh, Mei Ling/0009-0007-2411-8694
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NR 22
TC 12
Z9 14
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1356
EP 1365
DI 10.1111/iwj.13406
EA MAY 2020
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000534955800001
PM 32447838
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Huang, YL
   Ju, F
   Lai, SC
   Chen, ZC
   Chen, XY
   Zhou, LH
   Fu, MX
AF Huang, Y. L.
   Ju, F.
   Lai, S. C.
   Chen, Z. C.
   Chen, X. Y.
   Zhou, L. H.
   Fu, M. X.
TI EFFECTS OF NEGATIVE PRESSURE WOUND THERAPY ASSOCIATED WITH LOCAL INSULIN
   INJECTION ON TGF-β1 EXPRESSION IN DIABETIC FOOT WOUNDS
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE diabetic foot; negative-pressure wound therapy; insulin; transforming
   growth factor beta 1
ID RESISTANCE
C1 [Huang, Y. L.; Ju, F.; Lai, S. C.; Chen, Z. C.; Chen, X. Y.; Zhou, L. H.; Fu, M. X.] Hainan Med Coll, Affiliated Hosp 2, Dept Endocrinol, Haikou 70311, Hainan, Peoples R China.
C3 Hainan Medical University
RP Fu, MX (通讯作者)，Hainan Med Coll, Affiliated Hosp 2, Dept Endocrinol, Haikou 70311, Hainan, Peoples R China.
EM fumaoxiong_haikmd@163.com
RI Zhou, Linghui/ABB-1729-2021
CR Branski LK, 2009, BURNS, V35, P171, DOI 10.1016/j.burns.2008.03.009
   Calina D, 2017, MOL MED REP, V15, P681, DOI 10.3892/mmr.2016.6034
   Giangreco A, 2010, J INVEST DERMATOL, V130, P604, DOI 10.1038/jid.2009.297
   Lima MHM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036974
   Sepúlveda G, 2009, CIR ESPAN, V86, P171, DOI 10.1016/j.ciresp.2009.03.020
   Wang J, 2015, MINERVA CHIR, V70, P17
   Wang L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01116-5
   Wentworth JM, 2010, DIABETES, V59, P1648, DOI 10.2337/db09-0287
   Zhang PZ, 2017, ANN MED, V49, P106, DOI 10.1080/07853890.2016.1231932
NR 9
TC 0
Z9 0
U1 0
U2 14
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD MAR-APR
PY 2020
VL 34
IS 2
BP 559
EP 564
PG 6
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA LQ8FL
UT WOS:000535233600027
PM 32506883
DA 2026-07-24
ER
PT J
AU Shimono, A
   Sakuma, H
   Watanabe, S
   Kono, H
AF Shimono, Ayano
   Sakuma, Hisashi
   Watanabe, Shiho
   Kono, Hikaru
TI Effective combination of lymphatico-venous anastomosis and negative
   pressure wound therapy for lymphocyst: A Case Study
SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
LA English
DT Article
DE lymph node excision; lymphatic cyst; negative pressure wound therapy;
   surgical anastomosis; vaginal cancer
AB Lymphorrhea and lymphocysts are complications that occur after lymph node dissection or biopsy and are difficult to treat. Conventional treatments for lymphocysts are not always effective. For instance, lymphatico-venous anastomosis has a limited treatment efficacy when the cyst wall is thickened, and negative pressure wound therapy is limited by the installation site and longer treatment times. To overcome these individual shortcomings, we aimed to assess whether a combination of both interventions would be effective. In this study, we report the application of a lymphatico-venous anastomosis combined with negative pressure wound therapy for treating bilateral inguinal lymph nodes and pelvic lymph node dissection following treatment of vaginal cancer. Short-term improvements were observed with no recurrence of lymphocysts at 1-year follow-up.
C1 [Shimono, Ayano; Sakuma, Hisashi] Yokohama Municipal Citizens Hosp, Dept Plast & Reconstruct Surg, 56 Okazawa, Yokohama, Kanagawa 2408555, Japan.
   [Watanabe, Shiho] Tokyo Saiseikai Cent Hosp, Dept Plast & Reconstruct Surg, Tokyo, Japan.
   [Kono, Hikaru] Natl Ctr Child Hlth & Dev, Dept Plast & Reconstruct Surg, Tokyo, Japan.
C3 Tokyo Saiseikai Central Hospital; National Center for Child Health &
   Development - Japan
RP Shimono, A (通讯作者)，Yokohama Municipal Citizens Hosp, Dept Plast & Reconstruct Surg, 56 Okazawa, Yokohama, Kanagawa 2408555, Japan.
EM prsshimono@gmail.com
CR FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
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   Hamed O, 2008, J VASC SURG, V48, P1520, DOI 10.1016/j.jvs.2008.07.059
   Ito Y, 2012, NIHON HINYOKIKA GAKK, V103, P22
   Iwamoto T, 2008, APPL LYMPHATIC VENOU, V22, P80
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   Tauber R, 2013, J PLAST RECONSTR AES, V66, P390, DOI 10.1016/j.bjps.2012.09.030
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   Yuan Y, 2019, J SURG RES, V235, P329, DOI 10.1016/j.jss.2018.09.065
NR 10
TC 1
Z9 2
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1341-8076
EI 1447-0756
J9 J OBSTET GYNAECOL RE
JI J. Obstet. Gynaecol. Res.
PD JUL
PY 2020
VL 46
IS 7
BP 1224
EP 1228
DI 10.1111/jog.14300
EA MAY 2020
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA ME2NK
UT WOS:000535853500001
PM 32464690
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Shiroky, J
   Lillie, E
   Muaddi, H
   Sevigny, M
   Choi, WJ
   Karanicolas, PJ
AF Shiroky, Jonah
   Lillie, Erin
   Muaddi, Hala
   Sevigny, Marika
   Choi, Woo Jin
   Karanicolas, Paul J.
TI The impact of negative pressure wound therapy for closed surgical
   incisions on surgical site infection: A systematic review and
   meta-analysis
SO SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; OBESE WOMEN; PRIMARY HIP;
   SURGERY; COMPLICATIONS; MANAGEMENT; DRESSINGS; RISK; KNEE
AB Background: Surgical site infections cause substantial morbidity and mortality. Negative pressure wound therapy may reduce the risk of surgical site infections, but current evidence is unclear. The objective of this study was to examine whether negative pressure wound therapy reduces the risk of surgical site infections and other wound complications when compared with conventional dressings in all patients with primarily closed surgical wounds.
   Methods: A comprehensive systematic review of randomized controlled trials was conducted. Trials that compared a negative pressure wound therapy system to any non-negative pressure wound therapy dressing in surgical wound(s) intended to heal by primary intention were eligible. Surgical site infection was the primary outcome, and secondary outcomes included wound dehiscence, pain, seroma, healing time, length of stay, device-related complications, cost-effectiveness, and quality of life. Selection, extraction, and risk of bias steps were done in duplicate, and data were synthesized using random effects meta-analyses. A priori sensitivity and subgroup analyses of the primary outcome were completed. The Grading of Recommendations, Assessment, Development, and Evaluations framework was used to appraise the quality of the evidence.
   Results: Forty-four randomized controlled trials with N = 5,693 patients were included. Patients treated with negative pressure wound therapy experienced nearly a 40% reduction in the risk of surgical site infections relative to those with conventional dressings, which was statistically significant: pooled risk ratio 0.61, 95% confidence interval 0.49-0.74, I-2 = 26%. The effect remained consistent across surgical specialties and brands of negative pressure wound therapy devices. A statistically significant reduction in wound dehiscence and seroma incidence was also observed.
   Conclusion: There is moderate certainty that negative pressure wound therapy applied to closed surgical incisions reduces the risk of surgical site infections across all surgical procedures. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Shiroky, Jonah; Karanicolas, Paul J.] Sunnybrook Hlth Sci Ctr, Div Gen Surg, Toronto, ON, Canada.
   [Lillie, Erin; Karanicolas, Paul J.] Sunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON, Canada.
   [Muaddi, Hala; Sevigny, Marika; Choi, Woo Jin; Karanicolas, Paul J.] Univ Toronto, Dept Surg, Div Gen Surg, Toronto, ON, Canada.
   [Karanicolas, Paul J.] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada.
C3 University of Toronto; Sunnybrook Research Institute; Sunnybrook Health
   Science Center; University of Toronto; Sunnybrook Research Institute;
   Sunnybrook Health Science Center; University of Toronto; University of
   Toronto
RP Karanicolas, PJ (通讯作者)，Sunnybrook Hlth Sci Ctr, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada.
EM Paul.Karanicolas@sunnybrook.ca
RI ; Muaddi, Hala/AAE-1264-2021
OI Shiroky, Jonah/0000-0003-1113-9676; Muaddi, Hala/0000-0001-9721-2808
CR [Anonymous], GRADEPRO GDT GRADEPR
   [Anonymous], INCISIONAL NEGATIVE
   [Anonymous], BJOG
   [Anonymous], 2017, GRADE handbook for grading quality of evidence and strength of recommendations
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   [Anonymous], 2013, ClinicalTrials Gov Identifier: NCT00654641
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   [Anonymous], 2017, NAT HEALTHC SAF NETW
   [Anonymous], 2018, COLORECTAL DIS
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NR 77
TC 70
Z9 86
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
EI 1532-7361
J9 SURGERY
JI Surgery
PD JUN
PY 2020
VL 167
IS 6
BP 1001
EP 1009
DI 10.1016/j.surg.2020.01.018
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LS2GR
UT WOS:000536208400021
PM 32143842
DA 2026-07-24
ER
PT J
AU Maduba, CC
   Nnadozie, UU
   Modekwe, VI
   Onah, II
AF Maduba, Charles Chidiebele
   Nnadozie, Ugochukwu Uzodimma
   Modekwe, Victor Ifeanyichukwu
   Onah, Ifeanyichukwu Igwilo
TI Split Skin Graft Take in Leg Ulcers: Conventional Dressing Versus
   Locally Adapted Negative Pressure Dressing
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Graft take; Leg ulcers; Negative pressure dressing; Split-thickness skin
   grafting; Conventional dressing
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; EXPERIENCE
AB Background: Split-thickness skin grafting is widely used in the management of leg ulcers but is fraught with suboptimal take especially in less than ideal wound beds. The use of negative pressure dressing to prepare wound beds is an established practice. However, its use to improve graft survival is yet to be a common practice. We aim to compare quantitative and qualitative split thickness skin graft take in leg and foot ulcers using either traditional wound dressing or negative pressure dressing methods.
   Methods: Sixty-two cases were recruited for the study and assigned into two groups of 31 cases each by convenient sampling method. Group A patients had negative pressure dressings in both phases, whereas group B patients had traditional wound dressing in both phases. The percentage skin graft take for both groups, and the pattern of complications were assessed. Results were analyzed using IBM SPSS statistics for windows (version 21.0; IBM Corp, Armonk, NY). Student t-test was used to compare the percentage graft take, whereas Chi-square was used to compare significance of complications in both dressing methods.
   Results: The negative pressure dressing showed better skin graft take with mean value of 99.2 +/- 0.95% compared with traditional dressing with mean take of 89.7 +/- 6.44%, which was statistically significant with a P value of <0.001. The complication rate was 12.9% in the negative pressure dressing group and 96.8% in the traditional wound dressing group, showing about 7.5 times more complication in the traditional wound dressing. This is statistically significant with a P value < 0.001.
   Conclusions: Negative pressure dressing for split-thickness skin graft contributes significantly to improved split-thickness skin graft take with reduced complication rate as compared with conventional wound dressing method. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Maduba, Charles Chidiebele; Nnadozie, Ugochukwu Uzodimma] Alex Ekwueme Fed Univ, Dept Surg, Teaching Hosp, Abakaliki, Nigeria.
   [Nnadozie, Ugochukwu Uzodimma] Ebonyi State Univ, Dept Surg, Abakaliki, Nigeria.
   [Modekwe, Victor Ifeanyichukwu] Nnamdi Azikiwe Univ, Dept Surg, Div Paediat Surg, Teaching Hosp, Nnewi, Nigeria.
   [Onah, Ifeanyichukwu Igwilo] Natl Orthopaed Hosp, Dept Plast Surg, Enugu, Nigeria.
RP Maduba, CC (通讯作者)，Alex Ekwueme Fed Univ, Dept Surg, Teaching Hosp Abakaliki, PMB 102, Abakaliki, Ebonyi State, Nigeria.
EM charlesmaduba@gmail.com
RI Nnadozie, Ugochukwu/AFS-5496-2022; Modekwe, Victor/AAY-9300-2021
CR Anderson JJ, 2012, DIABET FOOT ANKLE, V3, DOI 10.3402/dfa.v3i0.10204
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   [Anonymous], CLIN RANDOMIZED CONT
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NR 18
TC 16
Z9 18
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD JUL
PY 2020
VL 251
BP 296
EP 302
DI 10.1016/j.jss.2020.01.029
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LT2SB
UT WOS:000536920900038
PM 32199338
DA 2026-07-24
ER
PT J
AU Steen, EH
   Wang, XY
   Boochoon, KS
   Ewing, DC
   Strang, HE
   Kaul, A
   Masri, L
   Balaji, S
   Hollier, LH 
   Keswani, S
AF Steen, Emily H.
   Wang, Xinyi
   Boochoon, Kieran S.
   Ewing, Donald C.
   Strang, Harrison E.
   Kaul, Aditya
   Masri, Leighanne
   Balaji, Swathi
   Hollier, Larry H., Jr.
   Keswani, Sundeep
TI Wound Healing and Wound Care in Neonates: Current Therapies and Novel
   Options
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE alginate; adhesive; collagen dressing; foam; hydrocolloid; hydrogel;
   moisture-associated skin damage; negative-pressure wound therapy;
   neonate; wound healing
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; PRESSURE; HYDROGEL; SKIN
AB GENERAL PURPOSE To provide wound care information that considers the specific physiology of neonates.
   TARGET AUDIENCE This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.
   LEARNING OBJECTIVES/OUTCOMES After participating in this educational activity, the participant will: 1. Differentiate the use of hydrocolloids, hydrogels, foam dressings, and barrier creams in the neonatal population. 2. Identify issues related to the use of solvents, alginates, collagen dressings, and negative-pressure wound therapy in neonates.
   ABSTRACT
   OBJECTIVE To discuss what is known about the wound milieu in premature and full-term neonates, including the unique challenges pediatric clinicians face, the therapies that have proven effective, and the therapies contraindicated for use in neonatal wound healing to guide treatment that accounts for the specific physiological characteristics of this often overlooked population.
   DATA SOURCES Data were collected on neonatal wound healing from a wide variety of sources, including PubMed, Google Scholar, journals, and textbooks.
   STUDY SELECTION Selection criteria included publications focused on the differences and nuances of wound healing in neonates in comparison with all other age groups.
   DATA EXTRACTION Data were extracted based on articles covering wound healing therapies with proven effectiveness in neonates. Terms for neonatal wound care were compiled, and then a comprehensive literature search was performed by the authors.
   DATA SYNTHESIS Although many therapies are safe for treatment of older children and adolescents, most have not been explicitly tested for neonatal use. This article reviews therapies with proven effectiveness and/or specific concerns in the neonatal population.
   CONCLUSION This review sheds light on the advantages and disadvantages of current standards of care regarding wound healing for neonates to direct researchers and clinicians toward developing treatments specifically for this delicate population.
C1 [Steen, Emily H.] Baylor Coll Med, Dept Surg, Houston, TX 77030 USA.
   [Wang, Xinyi; Strang, Harrison E.; Kaul, Aditya; Masri, Leighanne; Balaji, Swathi] Texas Childrens Hosp, Dept Surg, Lab Regenerat Tissue Repair, Houston, TX 77030 USA.
   [Boochoon, Kieran S.; Ewing, Donald C.] Texas A&M Coll Med, Bryan, TX USA.
   [Hollier, Larry H., Jr.; Keswani, Sundeep] Baylor Coll Med, Houston, TX 77030 USA.
   [Hollier, Larry H., Jr.; Keswani, Sundeep] Texas Childrens Hosp, Dept Surg, Div Plast Surg, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   Medical Hospital; Texas A&M University System; Texas A&M University
   College Station; Texas A&M Health Science Center; Baylor College of
   Medicine; Baylor College of Medicine; Baylor College Medical Hospital
RP Steen, EH (通讯作者)，Baylor Coll Med, Dept Surg, Houston, TX 77030 USA.
RI Wang, Xinyi/AAN-4271-2020
OI Wang, Xinyi/0000-0003-1780-7719
FU National Institute of General Medical Sciences [R01GM111808] Funding
   Source: NIH RePORTER
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NR 30
TC 14
Z9 23
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUN
PY 2020
VL 33
IS 6
BP 294
EP 300
DI 10.1097/01.ASW.0000661804.09496.8c
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA LT5MB
UT WOS:000537113600005
PM 32427785
DA 2026-07-24
ER
PT J
AU Brown, S
   Nixon, J
   Ransom, M
   Gilberts, R
   Dewhirst, N
   McGinnis, E
   Longo, R
   Game, F
   Bojke, C
   Chadwick, P
   Chandrasekar, A
   Chetter, I
   Collier, H
   Fernandez, C
   Homer-Vanniasinkam, S
   Jude, E
   Leigh, R
   Lomas, R
   Vowden, P
   Wason, J
   Sharples, L
   Russell, D
AF Brown, Sarah
   Nixon, Jane
   Ransom, Myka
   Gilberts, Rachael
   Dewhirst, Nikki
   McGinnis, Elizabeth
   Longo, Roberta
   Game, Frances
   Bojke, Chris
   Chadwick, Paul
   Chandrasekar, Akila
   Chetter, Ian
   Collier, Howard
   Fernandez, Catherine
   Homer-Vanniasinkam, Shervanthi
   Jude, Edward
   Leigh, Richard
   Lomas, Richard
   Vowden, Peter
   Wason, James
   Sharples, Linda
   Russell, David
TI Multiple Interventions for Diabetic Foot Ulcer Treatment Trial (MIDFUT):
   study protocol for a randomised controlled trial
SO BMJ OPEN
LA English
DT Article
ID COST-EFFECTIVENESS; RISK-FACTORS; MANAGEMENT; INDIVIDUALS; INFECTIONS;
   PREVALENCE; PREVENTION; NEUROPATHY; PREDICTOR; DIAGNOSIS
AB Introduction Diabetes affects more than 425 million people worldwide with a lifetime risk of diabetic foot ulcer (DFU) of up to 25%. Management includes wound debridement, wound dressings, offloading, treatment of infection and ischaemia, optimising glycaemic control; use of advanced adjuvant therapies is limited by high cost and lack of robust evidence.
   Methods and analysis A multicentre, seamless phase II/III, open, parallel group, multi-arm multi-stage randomised controlled trial in patients with a hard-to-heal DFU, with blinded outcome assessment. A maximum of 447 participants will be randomised (245 participants in phase II and 202 participants in phase III). The phase II primary objective will determine the efficacy of treatment strategies including hydrosurgical debridement +/- decellularised dermal allograft, or the combination with negative pressure wound therapy, as an adjunct to treatment as usual (TAU), compared with TAU alone, with patients randomised in a 1:1:1:2 allocation. The outcome is achieving at least 50% reduction in index ulcer area at 4 weeks post randomisation. The phase III primary objective will determine whether one treatment strategy, continued from phase II, reduces time to healing of the index ulcer compared with TAU alone, with participants randomised in a 1:1 allocation. Secondary objectives will compare healing status of the index ulcer, infection rate, reulceration, quality of life, cost-effectiveness and incidence of adverse events over 52 weeks post randomisation. Phase II and phase III primary endpoint analysis will be conducted using a mixed-effects logistic regression model and Cox proportional hazards regression, respectively. A within-trial economic evaluation will be undertaken; the primary economic analysis will be a cost-utility analysis presenting ICERs for each treatment strategy in rank order of effectiveness, with effects expressed as quality-adjusted life years. The trial has predefined progression criteria for the selection of one treatment strategy into phase III based on efficacy, safety and costs at 4 weeks.
C1 [Brown, Sarah; Nixon, Jane; Ransom, Myka; Gilberts, Rachael; Dewhirst, Nikki; McGinnis, Elizabeth; Collier, Howard; Fernandez, Catherine; Russell, David] Univ Leeds, Leeds Inst Clin Trials Res, Clin Trials Res Unit, Leeds, W Yorkshire, England.
   [Dewhirst, Nikki; McGinnis, Elizabeth; Homer-Vanniasinkam, Shervanthi; Russell, David] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England.
   [Longo, Roberta; Bojke, Chris] Univ Leeds, Acad Unit Hlth Econ, Leeds Inst Hlth Sci, Leeds, W Yorkshire, England.
   [Game, Frances] Derby Teaching Hosp NHS Fundat Trust, Derby, England.
   [Chadwick, Paul] Coll Podiatry, London, England.
   [Chandrasekar, Akila; Lomas, Richard] NHS Blood & Transplant, Liverpool, Merseyside, England.
   [Chetter, Ian] Univ Hull, Kingston Upon Hull, N Humberside, England.
   [Jude, Edward] Tameside Gen Hosp, Manchester, Lancs, England.
   [Leigh, Richard] Royal Free London NHS Fdn Trust, London, England.
   [Vowden, Peter] Bradford Teaching Hosp NHS Fdn Trust, Bradford, W Yorkshire, England.
   [Wason, James] Univ Cambridge, MRC Biostat Unit, Cambridge, England.
   [Wason, James] Newcastle Univ, Populat Hlth Sci Inst, Newcastle Upon Tyne, Tyne & Wear, England.
   [Sharples, Linda] London Sch Hyg & Trop Med, Dept Med Stat, London, England.
C3 University of Leeds; University of Leeds; University of Leeds;
   University of Hull; University of London; University College London;
   Royal Free London NHS Foundation Trust; University of Cambridge; MRC
   Biostatistics Unit; Newcastle University - UK; University of London;
   London School of Hygiene & Tropical Medicine
RP Brown, S (通讯作者)，Univ Leeds, Leeds Inst Clin Trials Res, Clin Trials Res Unit, Leeds, W Yorkshire, England.
EM medsbro@leeds.ac.uk
RI ; Russell, David/IXN-3147-2023; McGinnis, Elizabeth/PNF-2864-2026;
   /R-2354-2019; Longo, Roberta/ABB-5448-2020
OI Sharples, Linda/0000-0003-0894-966X; Game, Frances/0000-0002-5294-4789;
   Gilberts, Rachael/0000-0003-3326-7900; Brown, Sarah
   Tess/0000-0002-1840-3786; McGinnis, Elizabeth/0000-0002-2848-9149;
   Bojke, Chris/0000-0003-2601-0314; chetter, ian/0000-0002-2566-6859;
   Russell, David/0000-0002-1293-5618; Homer-Vanniasinkam,
   Shervanthi/0000-0001-6234-5053; Fernandez,
   Catherine/0000-0001-8561-5642; Wason, James/0000-0002-4691-126X; Ransom,
   Myka/0000-0003-4359-8287; 
FU (National Institute for Health Research) NIHR Health Technology
   Assessment (HTA) Programme [15/08/77]; NHS Blood and Transplant; Medical
   Research Council [MR/N028171/1, MC_UU_00002/6] Funding Source:
   researchfish; National Institute for Health Research [15/08/77] Funding
   Source: researchfish; MRC [MR/N028171/1, MC_UU_00002/6] Funding Source:
   UKRI
FX This study was funded by the (National Institute for Health Research)
   NIHR Health Technology Assessment (HTA) Programme (Project: 15/08/77).
   The views and opinions expressed therein are those of the authors and do
   not necessarily reflect those of the HTA, NIHR, NHS or Department of
   Health. We received product support for Versajet consoles and NPWT pumps
   from Smith & Nephew. We also received support for DCD from NHS Blood and
   Transplant and a 160K pound research support grant to cover excess
   treatment costs for consumables.
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   World Health Organization, 2016, Switzerland
NR 45
TC 11
Z9 15
U1 1
U2 20
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD APR
PY 2020
VL 10
IS 4
AR e035947
DI 10.1136/bmjopen-2019-035947
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LV0RG
UT WOS:000538150800105
PM 32312727
OA Green Accepted, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU O'Neill, CH
   Martin, RCG 
AF O'Neill, Conor H.
   Martin, Robert C. G., II
TI Negative-pressure wound therapy does not reduce superficial SSI in
   pancreatectomy and hepatectomy procedures
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE HPB surgery; negative pressure wound therapy; SSI; surgical site
   infection
ID SURGICAL SITE INFECTION; CARE-ASSOCIATED INFECTIONS; IMPROVEMENT
   PROJECTS; PREVENTION; GUIDELINE; HOSPITALS; OUTCOMES; IMPACT; COSTS;
   RISK
AB Introduction Surgical site infections (SSIs) lead to increased morbidity and cost. Negative-pressure wound therapy (NPWT) removes wound exudate and improves local blood flow, but its effect on SSI is unproven following hepatectomy and pancreatectomy. The aim of this trial was to evaluate the effect of NPWT on SSI in this population.
   Methods Patients were randomized to incisional NPWT or sterile island dressing following surgery. SSI predictive factors were recorded as well as patient comorbidities. Wound complications and type of SSI were recorded prospectively.
   Results Forty patients received the standardized perioperative bundle. Twenty patients received sterile island: 11 hepatic and 9 pancreatic resections; 20 patients received NPWT: 11 hepatic and 9 pancreatic resections; 23 patients were male; mean age 60.8 years (SD +/- 10.3); mean BMI 31.7 (SD +/- 7.0). There were three incisional wound infections: two with sterile island, one with NPWT; six organ space infections: four sterile island and two NPWT. There were no significant differences in SSI rates between groups (P = .57).
   Conclusion NPWT does not improve SSI rates over simple sterile dressing following hepatectomy or pancreatectomy. Improvements in SSI must be directed toward organ-space infections, which are unaffected by NPWT.
C1 [O'Neill, Conor H.; Martin, Robert C. G., II] Univ Louisville, Hiram Polk Jr MD Dept Surg, Div Surg Oncol, Louisville, KY 40292 USA.
C3 University of Louisville
RP Martin, RCG  (通讯作者)，Upper Gastrointestinal & Hepatopancreaticobiliary, 315 E Broadway 311, Louisville, KY 40202 USA.
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NR 25
TC 14
Z9 16
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD SEP
PY 2020
VL 122
IS 3
BP 480
EP 486
DI 10.1002/jso.25980
EA JUN 2020
PG 7
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA MS1PJ
UT WOS:000538282500001
PM 32506498
DA 2026-07-24
ER
PT J
AU Moncrieff, MD
   Sharma, RA
   Gathura, E
   Heaton, MJ
AF Moncrieff, Marc D.
   Sharma, Riti A.
   Gathura, Esther
   Heaton, Martin J.
TI Improved Perioperative Seroma and Complication Rates Following the
   Application of a 2-Layer Negative Pressure Wound Therapy System After
   Inguinal Lymphadenectomy for Metastatic Cutaneous Melanoma
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Article
ID LYMPH; PREVENTION; DISSECTION; MORBIDITY; COHORT
AB Background Perioperative complications following inguinal lymphadenectomy, including seroma formation, are frequent. We have employed a 2-layer negative pressure wound therapy (2-LNPWT) as a method to reduce seroma rate and perioperative complications. We present the outcome of our initial experience with 2-LNPWT and compare the outcomes of its use with traditional closed suction drains (CSDs). Materials and methods A non-randomised retrospective case-control series was analysed. Surgeons performing inguinal lymphadenectomy for metastatic cutaneous melanoma utilised either the 2-LNPWT therapy or traditional CSDs according to their practice preference. Results The study included 111 patients. The cohorts were well matched for gender, disease burden, body mass index and comorbidities. The 2-LNPWT technique was associated with significantly better postoperative outcomes than CSD, in terms of incidence of seroma formation (26.9% vs 49.4%; p < 0.03), period of drainage (15 days vs 20 days; p = 0.005) and return to theatre rate (0% vs 15.3%; p = 0.03). The overall seroma rate was 44.1%. The only significant association with seroma initiation was the type of drainage system used (2-LNPWT 31.2% vs CSD 58.3%; p < 0.03; OR 3.0). The method of drainage did not alter the course of an established seroma. There was no significant difference in overall or disease-specific survival detected between the 2 groups. Conclusion This retrospective non-randomised case control study has demonstrated the safe use of a novel application of negative pressure wound therapy that significantly reduced the incidence of seroma formation and postoperative complication rate for inguinal lymphadenectomy for melanoma.
C1 [Moncrieff, Marc D.; Sharma, Riti A.; Gathura, Esther; Heaton, Martin J.] Norfolk & Norwich Univ Hosp NHS Fdn Trust, Dept Plast & Reconstruct Surg, Norwich, Norfolk, England.
   [Moncrieff, Marc D.; Sharma, Riti A.] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
C3 Norfolk & Norwich University Hospitals NHS Foundation Trust; University
   of East Anglia
RP Moncrieff, MD (通讯作者)，Norfolk & Norwich Univ Hosp NHS Fdn Trust, Dept Plast & Reconstruct Surg, Norwich, Norfolk, England.; Moncrieff, MD (通讯作者)，Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
EM marc.moncrieff@nnuh.nhs.uk
OI Moncrieff, Marc/0000-0003-4492-235X
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PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1068-9265
EI 1534-4681
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD OCT
PY 2020
VL 27
IS 10
BP 3692
EP 3701
DI 10.1245/s10434-020-08513-7
EA JUN 2020
PG 10
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA NJ1JU
UT WOS:000538488200002
PM 32504367
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU McNamara, SA
   Hirt, PA
   Weigelt, MA
   Nanda, S
   de Bedout, V
   Kirsner, RS
   Schachner, LA
AF McNamara, Stephanie A.
   Hirt, Penelope A.
   Weigelt, Maximillian A.
   Nanda, Sonali
   de Bedout, Valeria
   Kirsner, Robert S.
   Schachner, Lawrence A.
TI Traditional and advanced therapeutic modalities for wounds in the
   paediatric population: an evidence-based review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE antibiotics; dressings; epidermolysis bullosa; matrices; paediatric
   wounds; pressure ulcers
ID AMNION/CHORION MEMBRANE ALLOGRAFTS; DERMAL REGENERATION TEMPLATE;
   PRESSURE ULCER PREVALENCE; SURGICAL SITE INFECTIONS; INTEGRA ARTIFICIAL
   SKIN; VACUUM-ASSISTED CLOSURE; EPIDERMOLYSIS-BULLOSA; HYDROSURGERY
   SYSTEM; TOPICAL TIMOLOL; PYODERMA-GANGRENOSUM
AB Objective: Children can have non-healing wounds due to a wide range of pathologies, including epidermolysis bullosa (EB), pilonidal disease and Stevens-Johnson syndrome, with some causes being iatrogenic, including extravasation injuries and medical devicerelated hospital-acquired pressure ulcers. Furthermore, paediatric wounds are vastly different from adult wounds and therefore require a different treatment approach. While there are numerous types of dressings, topical remedies, and matrices with high-tier evidence to support their use in adults, evidence is scarce in the neonatal and paediatric age groups. The purpose of this review is to discuss the basic principles in paediatric wound management, as well as to present new treatment findings published in the literature to date.The benefits and risks of using different types of debridement are discussed in this review. Various topical formulations are also described, including the need to use antibiotics judiciously.
   Method: Databases were searched for relevant sources including Pubmed, Embase, Web of Science and DynaMed. Search terms used included 'wound care', 'wound management', 'paediatrics', 'children', 'skin substitutes', and 'grafts'. Additionally, each treatment and disease entity was searched for relevant sources, including, for example: 'Apligraf', 'dermagraft', 'Manuka honey', 'antibiotic', 'timolol', and 'negative pressure wound therapy' (NPWT).
   Results: Amniotic membrane living skin equivalent is a cellular matrix that has been reportedly successful in treating paediatrics wounds and is currently under investigation in randomised clinical trials. Helicoll is an acellular matrix, which shows promise in children with recessive dystrophic EB. NPWT may be used as a tool to accelerate wound closure in children; however, caution must be taken due to limited evidence to support its safety and efficacy in the paediatric patient population. Integra has been reported as a useful adjunctive treatment to NPWT as both may act synergistically. Hospitalised children and neonates frequently have pressure ulcers, which is why prevention in this type of wound is paramount.
   Conclusion: Advancements in wound care are rapidly expanding. Various treatments for non-healing wounds in paediatric and neonatal patients have been reported, but high tier evidence in these populations is scarce. We hope to shed light on existing evidence regarding the different therapeutic modalities, from debridement techniques and dressing types to tissue substitutes and topical remedies. There have been promising results in many studies to date, but RCTs involving larger sample sizes are necessary, in order to determine the specific role these innovative agents play in paediatric wounds and to identify true safety and efficacy.
C1 [McNamara, Stephanie A.; Hirt, Penelope A.; Weigelt, Maximillian A.; Nanda, Sonali; de Bedout, Valeria; Kirsner, Robert S.; Schachner, Lawrence A.] Univ Miami, Miller Sch Med, Dr Phillip Frost Dermatol & Cutaneous Surg, 1321 NW 14th St,Suite 506, Miami, FL 33125 USA.
C3 University of Miami
RP McNamara, SA (通讯作者)，Univ Miami, Miller Sch Med, Dr Phillip Frost Dermatol & Cutaneous Surg, 1321 NW 14th St,Suite 506, Miami, FL 33125 USA.
EM s.mlacker@umiami.edu
RI Weigelt, Maximillian/LTD-8183-2024
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NR 154
TC 12
Z9 18
U1 0
U2 14
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2020
VL 29
IS 6
BP 321
EP 334
PG 14
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA LV6QY
UT WOS:000538560700004
PM 32530778
DA 2026-07-24
ER
PT J
AU Dong, JY
   Qing, C
   Song, F
   Wang, XQ
   Lu, SL
   Tian, M
AF Dong, Jiaoyun
   Qing, Chun
   Song, Fei
   Wang, Xiqiao
   Lu, Shuliang
   Tian, Ming
TI Potential molecular mechanisms of negative pressure in promoting wound
   healing
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cdc42; EGF; IFN-gamma; keratinocytes; negative pressure wound therapy;
   neutrophils; wound healing
ID VACUUM-ASSISTED-CLOSURE; TNF-ALPHA; IFN-GAMMA; THERAPY; FOOT;
   DEBRIDEMENT; NEUTROPHILS; EXPRESSION; CELLS; CDC42
AB Negative pressure wound therapy (NPWT) has been widely used in various lesions. This study aimed to explore the biological effects of negative pressure on the polymorphonuclear neutrophils (PMNs), macrophages, and epidermal keratinocyte cells involved in wound healing. PMNs differentiated from HL-60, macrophages were derived from THP-1 monocytes, and keratinocytes were cultured in vitro, and they were treated with 0, -0.03 mp, and -0.05 mp, respectively. Cell ultrastructure; viability; apoptosis; and protein factors such as tumour necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), epidermal growth factor (EGF), epidermal growth factor receptor (EGFR), interleukin-17 (IL-17), and cell division cycle 42 (Cdc42) were determined by transmission electron microscopy (TEM), CCK8, flow cytometry (FCM), ELISA, and simple Western assays, respectively. After negative pressure stimulation, the cell ultrastructure of PMNs and macrophages cells was presented with a marked increase of lysosomes and a relative decrease of mitochondria. In addition, the cell viability was enhanced in PMNs and macrophages in a pressure-dependent manner and apoptosis ratios were significantly reduced in PMNs and macrophages. In addition, under -0.05 negative pressure, IFN-gamma and IL-17 were significantly increased in PMNs or macrophages. Moreover, increased EGF and EGFR and Cdc42 levels in keratinocytes induced by the -0.05 mpa were detected, indicating that the migration chemotaxis of keratinocyte cells was enhanced. Negative pressure might promote cell proliferation, accelerate inflammatory responses, and promote epithelialisation during wound healing by increasing IFN-gamma, IL-17, Cdc42, EGF, and EGFR in PMNs, macrophages, or keratinocytes under different negative pressures.
C1 [Dong, Jiaoyun; Qing, Chun; Song, Fei; Wang, Xiqiao; Lu, Shuliang; Tian, Ming] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Burn Inst, 197 Ruijin Er Rd, Shanghai 20025, Peoples R China.
C3 Shanghai Jiao Tong University
RP Qing, C; Tian, M (通讯作者)，Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Burn Inst, 197 Ruijin Er Rd, Shanghai 20025, Peoples R China.
EM qspring@hotmail.com; tianming198@163.com
RI ; Wang, Xiqiao/U-3100-2019
OI Dong, Jiaoyun/0000-0001-7026-6582; Tian, Ming/0000-0003-1665-321X; 
FU National Natural Science Foundation of China [81670752, 81671916];
   Research and Innovation Project of Shanghai Municipal Education
   Commission [14YZ040]
FX National Natural Science Foundation of China, Grant/Award Numbers:
   81670752, 81671916; Research and Innovation Project of Shanghai
   Municipal Education Commission, Grant/Award Number: 14YZ040
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NR 42
TC 12
Z9 15
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1428
EP 1438
DI 10.1111/iwj.13423
EA JUN 2020
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000538863800001
PM 32515909
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Cui, HS
   Joo, SY
   Cho, YS
   Park, JH
   Kim, JB
   Seo, CH
AF Cui, Hui Song
   Joo, So Young
   Cho, Yoon Soo
   Park, Ji Heon
   Kim, June-Bum
   Seo, Cheong Hoon
TI Effect of Combining Low Temperature Plasma, Negative Pressure Wound
   Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound
   Healing Mouse Model
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE wound healing; low-temperature plasma; negative pressure wound therapy;
   bone marrow mesenchymal stem cell; re-epithelialization
ID BLOOD-FLOW; IN-VITRO; EXPRESSION; MURINE; ANGIOGENESIS; REPAIR
AB Low-temperature plasma (LTP; 3 min/day), negative pressure wound therapy (NPWT; 4 h/day), and bone marrow mesenchymal stem cells (MSCs; 1 x 10(6) cells/day) were used as mono- and combination therapy in an acute excisional skin wound-healing ICR mouse model. These therapies have been beneficial in treating wounds. We investigated the effectiveness of monotherapy with LTP, NPWT, and MSC and combination therapy with LTP + MSC, LTP + NPWT, NPWT + MSC, and LTP + NPWT + MSC on skin wounds in mice for seven consecutive days. Gene expression, protein expression, and epithelial thickness were analyzed using real time polymerase chain reaction (RT-qPCR), western blotting, and hematoxylin and eosin staining (H&E), respectively. Wound closure was also evaluated. Wound closure was significantly accelerated in monotherapy groups, whereas more accelerated in combination therapy groups. Tumor necrosis factor-alpha (TNF-alpha) expression was increased in the LTP monotherapy group but decreased in the NPWT, MSC, and combination therapy groups. Expressions of vascular endothelial growth factor (VEGF), alpha -smooth muscle actin (alpha -SMA), and type I collagen were increased in the combination therapy groups. Re-epithelialization was also considerably accelerated in combination therapy groups. Our findings suggest that combination therapy with LPT, NPWT, and MSC exert a synergistic effect on wound healing, representing a promising strategy for the treatment of acute wounds.
C1 [Cui, Hui Song; Park, Ji Heon] Hallym Univ, Burn Inst, Hangang Sacred Heart Hosp, Dept Rehabil Med,Coll Med, Seoul 07247, South Korea.
   [Joo, So Young; Cho, Yoon Soo; Seo, Cheong Hoon] Hallym Univ, Hangang Sacred Heart Hosp, Dept Rehabil Med, Coll Med, Seoul 07247, South Korea.
   [Kim, June-Bum] Hallym Univ, Hangang Sacred Heart Hosp, Dept Pediat, Coll Med, Seoul 07247, South Korea.
C3 Hallym University; Hallym University; Hallym University
RP Seo, CH (通讯作者)，Hallym Univ, Hangang Sacred Heart Hosp, Dept Rehabil Med, Coll Med, Seoul 07247, South Korea.; Kim, JB (通讯作者)，Hallym Univ, Hangang Sacred Heart Hosp, Dept Pediat, Coll Med, Seoul 07247, South Korea.
EM bioeast@hanmail.net; anyany98@naver.com; hamays@hanmail.net;
   jiheonpark84@naver.com; hoppdoctor@hanmail.net; chseomd@gmail.com
RI Seo, Cheong Hoon/V-4059-2019; Cho, Yoon Soo/JXL-2899-2024
OI Seo, Cheong Hoon/0000-0003-4091-6382; 
FU Hallym University Research Fund [HURF-2018-55]; Basic Science Research
   Program through the National Research Foundation of Korea (NRF) -
   Ministry of Education [NRF-2017R1D1A1A02018478, 2017R1D1A1B03029731]
FX This research was supported by the Hallym University Research Fund
   (HURF-2018-55) and Basic Science Research Program through the National
   Research Foundation of Korea (NRF) funded by the Ministry of Education
   (NRF-2017R1D1A1A02018478, 2017R1D1A1B03029731).
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NR 44
TC 18
Z9 20
U1 0
U2 17
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2020
VL 21
IS 10
AR 3675
DI 10.3390/ijms21103675
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LW7GO
UT WOS:000539312100271
PM 32456187
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhang, H
   Chen, GP
   Yu, YR
   Guo, JH
   Tan, Q
   Zhao, YN
AF Zhang, Han
   Chen, Guopu
   Yu, Yunru
   Guo, Jiahui
   Tan, Qian
   Zhao, Yuanjin
TI Microfluidic Printing of Slippery Textiles for Medical Drainage around
   Wounds
SO ADVANCED SCIENCE
LA English
DT Article
DE 3D printing; microfibers; microfluidics; wettability; wound healing
ID SURFACES; TRANSPARENT; ARRAYS
AB Surface materials with specific wettability play significant roles in existing fields from environmental protection to biomedicine. Here, a 3D droplet transport microfiber textile with slippery liquid-infused porous surface is presented for medical drainage around wounds. The textile is fabricated by using a simple capillary microfluidic printing method to continuously spin polyurethane microfibers with liquid paraffin-infused porous surface and print them into a 3D-structure. Benefiting from the specific surface porous structure and oil encapsulation of the microfibers, aqueous droplets could be nondestructively and rapidly transported not only in simple single, double or multiple microfiber systems, but also in the microfibers composed stereoscopic textile through the microfluidic 3D printing. Based on this feature, it is demonstrated that the 3D slippery microfiber textile coupled with a vacuum sealing drainage therapy could significantly enhance the wound exudation drainage efficiency, reduce tissue injury, and prolong the effective service life in versatile wounds management. Thus, it is believed that the slippery microfiber textiles have potential for clinical applications.
C1 [Zhang, Han; Chen, Guopu; Tan, Qian; Zhao, Yuanjin] Nanjing Univ, Sch Med, Affiliated Hosp, Dept Burns & Plast Surg,Nanjing Drum Tower Hosp, Nanjing 210008, Peoples R China.
   [Zhang, Han; Zhao, Yuanjin] Xuzhou Med Univ, Clin Coll, Nanjing Drum Tower Hosp, Dept Clin Lab, Nanjing 210008, Peoples R China.
   [Zhang, Han; Yu, Yunru; Guo, Jiahui; Zhao, Yuanjin] Southeast Univ, State Key Lab Bioelect, Sch Biol Sci & Med Engn, Nanjing 210096, Peoples R China.
C3 Nanjing University; Xuzhou Medical University; Nanjing University;
   Southeast University - China
RP Zhao, YN (通讯作者)，Nanjing Univ, Sch Med, Affiliated Hosp, Dept Burns & Plast Surg,Nanjing Drum Tower Hosp, Nanjing 210008, Peoples R China.; Zhao, YN (通讯作者)，Xuzhou Med Univ, Clin Coll, Nanjing Drum Tower Hosp, Dept Clin Lab, Nanjing 210008, Peoples R China.; Zhao, YN (通讯作者)，Southeast Univ, State Key Lab Bioelect, Sch Biol Sci & Med Engn, Nanjing 210096, Peoples R China.
EM yjzhao@seu.edu.cn
RI Zhao, Yuanjin/I-1861-2013; Zhang, Han/HSG-5211-2023
OI Zhao, Yuanjin/0000-0001-9242-4000; Yu, Yunru/0000-0003-3182-5753; 
FU National Natural Science Foundation of China [61927805, 51522302];
   Natural Science Foundation of Jiangsu [BE2018707]; Scientific Research
   Foundation of Nanjing University; Nanjing Drum Tower Hospital
FX H.Z. and G.P.C. contributed equally to this work. This work was
   supported by the National Natural Science Foundation of China (Grants
   61927805 and 51522302), the Natural Science Foundation of Jiangsu (Grant
   No. BE2018707), and the Scientific Research Foundation of Nanjing
   University and Nanjing Drum Tower Hospital. All rats were treated
   strictly according to the Laboratory Animal Care and Use Guidelines. All
   of the animal care and experimental procedures were reviewed and
   approved by the Animal Investigation Ethics Committee of Nanjing General
   Hospital of Nanjing Command.
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NR 39
TC 110
Z9 121
U1 4
U2 240
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
EI 2198-3844
J9 ADV SCI
JI Adv. Sci.
PD AUG
PY 2020
VL 7
IS 16
AR 2000789
DI 10.1002/advs.202000789
EA JUN 2020
PG 7
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA NQ7OW
UT WOS:000539600900001
PM 32832352
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pedrazzi, NE
   Naiken, S
   La Scala, G
AF Pedrazzi, Nadine Elisabeth
   Naiken, Surennaidoo
   La Scala, Giorgio
TI Negative Pressure Wound Therapy in Pediatric Burn Patients: A Systematic
   Review
SO ADVANCES IN WOUND CARE
LA English
DT Review
DE negative pressure wound therapy; infant; child; adolescent; burns
ID CHILDREN; INFANTS
AB Significance:Negative pressure wound therapy (NPWT) requires the placement of a dressing over a wound, covered with an adhesive film, and applying to these dressing a negative pressure in a controlled fashion. This therapy is a powerful complement to surgical care of wounds. Data are however poor on its use in pediatric burns. Recent Advances:This systematic review, including a total of 466 patients, shows that NPWT as the initial treatment for burned children and after skin grafting has been shown to produce promising results. In the majority of studies, skin graft take rate is close to 100%. This therapy is particularly beneficial in the pediatric population because of less frequent dressing changes and early mobilization. NPWT devices accurately quantify burns water losses and allow tailoring liquid resuscitation. Critical Issues:NPWT is not in the subject of controlled clinical trials in pediatric; most publications are case reports or retrospective reviews. The sporadic complications include bleeding, local infections, and mechanical device issues. Future Directions:NPWT has been used in 2-month up to 18-year-old children with deep second- to third-degree burn of multiple etiologies, from a few days up to several months, on small to 40% total body surface area (%), and in difficult areas. Data gathered provide empirical guidelines on NPWT use in pediatric burns using continuous mode with a pressure of -50 to -75 mmHg for children younger than 2 years, and -75 to -125 mmHg in children over 2 years of age. Prospective randomized studies are needed to provide validated rules.
C1 [Pedrazzi, Nadine Elisabeth; Naiken, Surennaidoo] Univ Geneva Hosp, Dept Surg, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland.
   [La Scala, Giorgio] Univ Geneva Childrens Hosp, Dept Pediat, Pediat Plast Surg, Geneva, Switzerland.
C3 University of Geneva; University of Geneva
RP Pedrazzi, NE (通讯作者)，Univ Geneva Hosp, Dept Surg, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland.
EM nadine.pedrazzi@hotmail.com
RI La Scala, Giorgio/AAM-8031-2020
FU Division of Pediatric Surgery, University of Geneva Children's
   Hospitals, Switzerland
FX This work was supported by the Division of Pediatric Surgery, University
   of Geneva Children's Hospitals, Switzerland. The authors would like to
   thank PD Dr. Pfurtscheller from the University Hospital Graz, Austria,
   for sharing the data of his study.
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NR 18
TC 17
Z9 23
U1 0
U2 13
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAY 1
PY 2021
VL 10
IS 5
BP 270
EP 280
DI 10.1089/wound.2019.1089
EA JUN 2020
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA RU2NT
UT WOS:000539607500001
PM 32320366
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Abadía, P
   Ocaña, J
   Ramos, D
   Pina, JD
   Moreno, I
   García, JC
   Rodríguez, G
   Tobaruela, E
   Die, J
AF Abadia, Pedro
   Ocana, Juan
   Ramos, Diego
   Pina, Juan D.
   Moreno, Irene
   Garcia, Juan C.
   Rodriguez, Gloria
   Tobaruela, Estela
   Die, Javier
TI Prophylactic Use of Negative Pressure Wound Therapy Reduces Surgical
   Site Infections in Elective Colorectal Surgery: A Prospective Cohort
   Study
SO SURGICAL INFECTIONS
LA English
DT Article
DE coloproctology; hospital stay; negative pressure wound therapy; surgical
   site infection
ID PREVENTION; LAPAROTOMY; TRIAL
AB Background:The main purpose was to assess the efficacy of negative pressure wound therapy (NPWT) for surgical site infection (SSI) in elective open and laparoscopic open-assisted colorectal surgery. The primary end point was to establish SSI within 30 days post-operatively. The secondary aim was hospital stay and to assess SSI predictors in a multivariable analysis. Patients and Methods:A prospective cohort study was undertaken between January 2017 and December 2018 in patients undergoing elective colorectal surgery, both through open and minimally invasive approaches, to whom NPWT or fully occlusive dressing were applied. Baseline data were compared between the two groups and multivariable analysis was performed to identify SSI risk factors. Results:Two hundred patients were included: 100 NPWT patients and 100 closed dressing patients. No differences between the two groups were found. The incidence of SSI in the control dressing group was 19% versus 9% in the NPWT group, which was substantially different (odds ratio [OR] 0.30; 95% confidence interval [CI] 0.11-0.83; p = 0.02). No differences were found in hospital length of stay (12.33 d in NPWT group vs. 12.39 d in the control group; p = 0.82). A body mass index (BMI) of 30-35 (p = 0.04), BMI >35 (p = 0.03), and midline wound (p = 2.68) were found to be predictors of SSI in multivariable analysis. Conclusion:The prophylactic use of NPWT in laparotomy incisions for patients undergoing elective colorectal surgery (both through open and laparoscopic approach) is associated with a reduction in SSI rates.
C1 [Abadia, Pedro; Ocana, Juan; Ramos, Diego; Pina, Juan D.; Moreno, Irene; Garcia, Juan C.; Rodriguez, Gloria; Tobaruela, Estela; Die, Javier] Hosp Univ Ramon y Cajal, Dept Gen & Digest Surg, Div Coloproctol, Madrid, Spain.
C3 Hospital Universitario Ramon y Cajal
RP Ocaña, J (通讯作者)，Hosp Univ Ramon y Cajal, Dept Gen & Digest Surg, Ctra Colmenar Viejo Km 9-100, Madrid 28034, Spain.
EM jocajim@gmail.com
RI ; Ramos, Diego/HSH-4501-2023; Ocaña, Juan/AAN-7494-2021; Moreno Torres,
   Irene del Pilar/AAY-5247-2021
OI die trill, javier/0000-0003-2116-9190; Ramos, Diego/0000-0003-0191-1968;
   Abadía Barnó, Peo/0000-0003-4713-9870; 
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NR 28
TC 9
Z9 11
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD MAR 1
PY 2021
VL 22
IS 2
BP 234
EP 239
DI 10.1089/sur.2019.309
EA JUN 2020
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA QO8UL
UT WOS:000539611700001
PM 32522098
DA 2026-07-24
ER
PT J
AU Joice, GA
   Tema, G
   Semerjian, A
   Gupta, M
   Bell, M
   Walker, J
   Kates, M
   Bivalacqua, TJ
AF Joice, Gregory A.
   Tema, Giorgia
   Semerjian, Alice
   Gupta, Mohit
   Bell, Michael
   Walker, Joanne
   Kates, Max
   Bivalacqua, Trinity J.
TI Evaluation of Incisional Negative Pressure Wound Therapy in the
   Prevention of Surgical Site Occurrences After Radical Cystectomy: A New
   Addition to Enhanced Recovery After Surgery Protocol
SO EUROPEAN UROLOGY FOCUS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COLORECTAL SURGERY; INFECTION; CARE; MORBIDITY;
   OUTCOMES; CANCER; COST; LAPAROTOMY; MANAGEMENT
C1 [Joice, Gregory A.; Semerjian, Alice; Gupta, Mohit; Bell, Michael; Walker, Joanne; Kates, Max; Bivalacqua, Trinity J.] Johns Hopkins Univ, Sch Med, James Buchanan Brady Urol Inst, Baltimore, MD USA.
   [Joice, Gregory A.; Semerjian, Alice; Gupta, Mohit; Bell, Michael; Walker, Joanne; Kates, Max; Bivalacqua, Trinity J.] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD USA.
   [Tema, Giorgia] Univ Roma La Sapienza, St Andrea Hosp, Dept Urol, Rome, Italy.
C3 Johns Hopkins University; Johns Hopkins University; Sapienza University
   Rome; Azienda Ospedaliera Sant'Andrea
RP Joice, GA (通讯作者)，600 North Wolfe St,Marburg 144, Baltimore, MD 21287 USA.
EM gjoice1@jhmi.edu
OI Semerjian, Alice/0000-0002-8031-993X
CR [Anonymous], 2016, UROL ONCOLSEMIN ORIG
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NR 29
TC 8
Z9 9
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2405-4569
J9 EUR UROL FOCUS
JI Eur. Urol. Focus
PD JUL 15
PY 2020
VL 6
IS 4
BP 698
EP 703
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA LZ3SO
UT WOS:000541148600016
PM 31704281
DA 2026-07-24
ER
PT J
AU Kim, PJ
   Lavery, LA
   Galiano, RD
   Salgado, CJ
   Orgill, DP
   Kovach, SJ
   Bernstein, BH
   Attinger, CE
AF Kim, Paul J.
   Lavery, Lawrence A.
   Galiano, Robert D.
   Salgado, Christopher J.
   Orgill, Dennis P.
   Kovach, Stephen J.
   Bernstein, Brent H.
   Attinger, Christopher E.
TI The impact of negative-pressure wound therapy with instillation on
   wounds requiring operative debridement: Pilot randomised, controlled
   trial
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bacterial load; negative-pressure wound therapy; topical
   negative-pressure therapy; wound cleansing; wound healing
ID VACUUM-ASSISTED CLOSURE; ANTIMICROBIAL SOLUTIONS; COMPLEX WOUNDS;
   MANAGEMENT; BIOBURDEN; EFFICACY; AGENTS
AB Presence of bacteria in wounds can delay healing. Addition of a regularly instilled topical solution over the wound during negative-pressure wound therapy (NPWT) may reduce bioburden levels compared with standard NPWT alone. We performed a prospective, randomised, multi-centre, post-market trial to compare effects of NPWT with instillation and dwell of polyhexamethylene biguanide solution vs NPWT without instillation therapy in wounds requiring operative debridement. Results showed a significantly greater mean decrease in total bacterial counts from time of initial surgical debridement to first dressing change in NPWT plus instillation (n = 69) subjects compared with standard NPWT (n = 63) subjects (-0.18 vs 0.6 log(10)CFU/g, respectively). There was no significant difference between the groups in the primary endpoint of required inpatient operating room debridements after initial debridement. Time to readiness for wound closure/coverage, proportion of wounds closed, and incidence of wound complications were similar. NPWT subjects had 3.1 times the risk of re-hospitalisation compared with NPWT plus instillation subjects. This study provides a basis for exploring research options to understand the impact of NPWT with instillation on wound healing.
C1 [Kim, Paul J.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
   [Galiano, Robert D.] Northwestern Mem Hosp, Chicago, IL USA.
   [Salgado, Christopher J.] Univ Miami Hlth Syst, Miami, FL USA.
   [Orgill, Dennis P.] Brigham & Womens Hosp, Wound Care Ctr, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   [Kovach, Stephen J.] Penn Plast Surg Univ City, Philadelphia, PA USA.
   [Bernstein, Brent H.] St Lukes Univ Hlth Network, Bethlehem, PA USA.
   [Attinger, Christopher E.] MedStar Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; Northwestern Memorial Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Georgetown
   University
RP Kim, PJ (通讯作者)，Univ Texas Southwestern, Dept Plast Surg, WA4-238,Outpatient Bldg,1801 Inwood Rd, Dallas, TX 75390 USA.
EM paul.kim@utsouthwestern.edu
RI Orgill, Dennis/H-7596-2019; /AAQ-9524-2020
OI Lavery, Lawrence/0000-0002-7920-9952; , Paul/0000-0002-6186-6890
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NR 39
TC 30
Z9 32
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1194
EP 1208
DI 10.1111/iwj.13424
EA JUN 2020
PG 15
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000541439900001
PM 32567234
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Geierlehner, A
   Horch, RE
   Müller-Seubert, W
   Arkudas, A
   Ludolph, I
AF Geierlehner, Alexander
   Horch, Raymund E.
   Mueller-Seubert, Wibke
   Arkudas, Andreas
   Ludolph, Ingo
TI Limb salvage procedure in immunocompromised patients with
   therapy-resistant leg ulcers-The value of ultra-radical debridement and
   instillation negative-pressure wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE chronic leg ulcer; negative-pressure wound therapy; skin
   transplantation; ultra-radical debridement
ID DIABETIC FOOT ULCERS; SURGICAL-TREATMENT; SKIN-GRAFT; MANAGEMENT; FLAP;
   RECONSTRUCTION; ULCERATION; AMPUTATION; ETIOLOGY; CLOSURE
AB The purpose of this study was to analyse the outcome of our established triple treatment strategy in therapy-resistant deep-thickness chronic lower leg ulcers. This limb salvage approach consists of ultra-radical surgical debridement, negative-pressure wound therapy (NPWT) with or without instillation, and split-thickness skin grafting. Between March 2003 and December 2019, a total of 16 patients and 24 severe cases of lower leg ulcers were eligible for inclusion in this highly selective population. A total of seven patients received immunosuppressive medication. Complete wound closure was achieved in 25% and almost 90% of included lower leg ulcer cases after 3 and 24 months of our triple treatment strategy, respectively. The overall limb salvage rate was 100%. Bacterial colonisation of these wounds was significantly reduced after multiple surgical debridements and NPWT. Fasciotomy and radical removal of devitalised tissue such as deep fascia, tendons, and muscles combined with NPWT showed promising results in terms of the overall graft take rate. This treatment strategy was considered as last resort for limb salvage in such a critically ill and immunocompromised patient population. Surgeons should be aware of its efficacy and consider the triple treatment strategy especially if no other limb salvage option remains.
C1 [Geierlehner, Alexander; Horch, Raymund E.; Mueller-Seubert, Wibke; Arkudas, Andreas; Ludolph, Ingo] Friedrich Alexander Univ Erlangen Nuernberg FAU, Dept Plast & Hand Surg, Lab Tissue Engn & Regenerat Med, Univ Hosp Erlangen, Krankenhausstr 12, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Geierlehner, A (通讯作者)，Friedrich Alexander Univ Erlangen Nuernberg FAU, Dept Plast & Hand Surg, Lab Tissue Engn & Regenerat Med, Univ Hosp Erlangen, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM alexander.geierlehner@uk-erlangen.de
RI Arkudas, Andreas/AAQ-6745-2021; Horch, Raymund E/H-8128-2019
OI Arkudas, Andreas/0000-0002-2473-5816; Horch, Raymund
   E/0000-0002-6561-2353
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NR 67
TC 16
Z9 16
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1496
EP 1507
DI 10.1111/iwj.13428
EA JUN 2020
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000541719100001
PM 32573103
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Lou, WJ
   Zou, K
   Yu, ZB
   Qin, S
   Wang, K
   Che, B
AF Lou, Wenjie
   Zou, Kai
   Yu, Zhongbin
   Qin, Song
   Wang, Kai
   Che, Biao
TI Cefazolin sodium pentahydrate combined with vacuum sealing drainage in
   the treatment of open fracture complicated with soft tissue injury
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Article
DE Fractures; open; Soft tissue injuries; Cefazolin; Negative-pressure
   wound therapy
ID WOUND-INFECTION; THERAPY; CLOSURE
AB OBJECTIVE: To investigate the clinical efficacy of cefazolin sodium pentahydrate combined with vacuum sealing drainage (VSD) in the treatment of open fracture complicated with soft tissue injury.
   METHODS: Sixty-three patients with open fracture complicated with soft tissue injury were divided into observation (n = 33) and control (n = 30) groups. After surgical reduction, fixation, and repair of the fractures, the control group was treated with VSD for 10 days, and the observation group was treated with cefazolin sodium pentahydrate based on VSD for 10 days. The infection control time was recorded. After treatment, the pain of patients was evaluated. Before and after treatment, the serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha), cortisol, epinephrine, norepinephrine, and glucose were detected. After 6 months of treatment, the total effective rate of the treatment was evaluated.
   RESULTS: The infection control time and Visual Analogue Scale score after treatment in the observation group were significantly lower than in the control group, respectively (P < 0.05). After the treatment, the serum levels of CRP, IL-6, IL-8, TNF-alpha, cortisol, epinephrine, norepinephrine, and glucose in each group were significantly lower than before the treatment (P <0.05), and each index in observation was significantly lower than in the control group (P < 0.05).
   CONCLUSIONS: In the treatment of open fractures complicated with soft tissue injury, cefazolin sodium pentahydrate combined with VSD can effectively reduce inflammation and stress, thus improving the treatment efficacy.
C1 [Lou, Wenjie; Zou, Kai; Yu, Zhongbin; Qin, Song; Wang, Kai; Che, Biao] Gen Hosp Yangtze River Shipping, Dept Orthoped, 5 Huiji Rd, Wuhan 430010, Peoples R China.
   [Lou, Wenjie; Zou, Kai; Yu, Zhongbin; Qin, Song; Wang, Kai; Che, Biao] Wuhan Brain Hosp, 5 Huiji Rd, Wuhan 430010, Peoples R China.
RP Che, B (通讯作者)，Gen Hosp Yangtze River Shipping, Dept Orthoped, 5 Huiji Rd, Wuhan 430010, Peoples R China.; Che, B (通讯作者)，Wuhan Brain Hosp, 5 Huiji Rd, Wuhan 430010, Peoples R China.
EM chebiaowh@163.com
RI /AAS-8070-2020
FU Yangtze River Administration of Navigational Affairs [201810009]
FX This work was supported by Yangtze River Administration of Navigational
   Affairs (No. 201810009).
CR Abdel-Hafez N M, 2007, Ann Burns Fire Disasters, V20, P89
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NR 19
TC 4
Z9 5
U1 0
U2 1
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PD APR
PY 2020
VL 66
IS 4
BP 430
EP 436
DI 10.1590/1806-9282.66.4.430
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MA3CI
UT WOS:000541794900012
PM 32578775
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zheng, SW
   Huang, XM
   Lin, YZ
   Chen, XH
   Lin, GH
   Zhuang, J
AF Zheng, Shengwu
   Huang, Xiongmei
   Lin, Yazhou
   Chen, Xiaohui
   Lin, Genhui
   Zhuang, Jing
TI Negative-pressure wound therapy (NPWT) for the treatment of pacemaker
   pocket infection in patients unable or unwilling to undergo CIED
   extraction
SO JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
LA English
DT Article
DE Pacemaker pocket infection; Treatment; NPWT; Retained CIED; Cardiology
ID ELECTRONIC DEVICE INFECTIONS; VACUUM-ASSISTED CLOSURE;
   CARDIOVERTER-DEFIBRILLATORS; MANAGEMENT; DIAGNOSIS; PREVENTION;
   GUIDELINES; TRENDS; RATES
AB Purpose The occurrence of cardiac pacemaker pocket infection has markedly increased and has become a new problem facing cardiovascular internists. The aim of our study was to investigate the effectiveness and safety of treating cardiac pacemaker pocket infection using negative-pressure wound therapy (NPWT) in patients who are unwilling or unable to have their cardiac implantable electronic devices (CIEDs) removed. Methods From March 2013 to April 2019, NPWT was applied to 26 patients with cardiac pacemaker pocket infection who were unwilling or unable to have their CIEDs removed. In the first stage, a negative-pressure drainage system was placed in the pacemaker pocket after debridement. Then, NPWT was used to seal the wound, and the negative pressure (300-400 mmHg) was sustained for 5-7 days. In the second stage, the pacemaker was relocated to the subpectoral layer, and the wound was closed. Results In all but three of our 26 patients, the wound healed completely without complications and without evidence of residual infection. The average follow-up period was 26.92 +/- 9.46 months. Only 3 diabetic patients whose tissue bacterial cultures revealed that methicillin-resistantStaphylococcus epidermidisdeveloped uncontrolled infections. Eventually, the entire original pacemaker systems were removed, and new pacemakers were implanted in the contralateral chest wall. Conclusions When warranted by strictly selected indications, the method of NPWT without CIED extraction can be considered as a new and effective treatment for patients with pacemaker pocket infection who are unwilling or unable to have the device removed.
C1 [Zheng, Shengwu; Huang, Xiongmei; Lin, Genhui; Zhuang, Jing] Fujian Med Univ, Shengli Clin Med Coll, Dept Burn & Plast Surg, Fujian Prov Hosp, 134 St East, Fuzhou 350001, Peoples R China.
   [Lin, Yazhou] Fujian Med Univ, Fujian Prov Hosp, Shengli Clin Med Coll, Dept Cardiol,Fujian Heart Dis Res Inst, Fuzhou, Peoples R China.
   [Chen, Xiaohui] Fujian Med Univ, Fujian Prov Hosp, Shengli Clin Med Coll, Dept Anesthesiol, Fuzhou, Peoples R China.
C3 Fujian Medical University; Fujian Provincial Hospital; Fujian Medical
   University; Fujian Provincial Hospital; Fujian Medical University;
   Fujian Provincial Hospital
RP Zheng, SW (通讯作者)，Fujian Med Univ, Shengli Clin Med Coll, Dept Burn & Plast Surg, Fujian Prov Hosp, 134 St East, Fuzhou 350001, Peoples R China.
EM dr.zhengshengwu@yahoo.com
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   Greenspon AJ, 2011, J AM COLL CARDIOL, V58, P1001, DOI 10.1016/j.jacc.2011.04.033
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NR 38
TC 7
Z9 9
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1383-875X
EI 1572-8595
J9 J INTERV CARD ELECTR
JI J. Interv. Card. Electrophysiol.
PD AUG
PY 2021
VL 61
IS 2
BP 245
EP 251
DI 10.1007/s10840-020-00805-y
EA JUN 2020
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA TS5WU
UT WOS:000542099300001
PM 32572720
OA hybrid
DA 2026-07-24
ER
PT J
AU Boland, PA
   Kelly, ME
   Donlon, NE
   Bolger, JC
   Mehigan, BJ
   McCormick, PH
   Larkin, JO
AF Boland, Patrick Anthony
   Kelly, Michael E.
   Donlon, Noel E.
   Bolger, Jarlath C.
   Mehigan, Brian J.
   McCormick, Paul H.
   Larkin, John O.
TI Prophylactic negative pressure wound therapy for closed laparotomy
   wounds: a systematic review and meta-analysis of randomised controlled
   trials
SO IRISH JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE Laparotomy; Negative pressure wound therapy; Surgical site infection;
   Wound care
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   PREVENTION; MANAGEMENT; GUIDELINE
AB Surgical site infections are a common source of post-operative morbidity and contribute significantly to healthcare costs. Patients undergoing emergency laparotomy and/or bowel surgery are particularly at risk. Prophylactic negative pressure wound therapy (NPWT) has been shown to reduce wound infection. However, to date, there has been a lack of consensus around its use for closed laparotomy wounds. We conducted a systematic review of randomised controlled trials comparing the use of prophylactic negative pressure wound therapy with standard dressings for closed laparotomy incisions. The primary outcome was incidence of incisional surgical site infection (SSI) at 30 days post-operatively. Secondary outcomes included superficial and deep SSI, skin dehiscence, fascial dehiscence and length of stay. A total of 2182 publications were identified, of which, following review of titles, abstracts and full texts, five studies met the criteria for inclusion. Across these studies, 467 patients were randomised to NPWT and 464 to standard dressings. Overall SSI rate was 18.6% (n = 87/467) versus 23.9% (n = 111/464) in the NPWT and standard dressing groups, respectively (Odds ratio 0.71, 95% CI 0.52-0.99,p = 0.04*). Deep SSI incidence was the same in both groups (2.6%). Both skin dehiscence and fascial dehiscence were slightly higher in the standard dressing group ((4.2%,n = 11/263 versus 3.1% (n = 8/261) and (0.9% (n = 3/324) versus 0.6% (n = 2/323)), respectively. This study observed that NPWT reduces the overall SSI for closed laparotomy wounds. It supports data recommending the use of prophylactic NPWT dressings, especially in high-risk patients in both emergency and elective circumstances.
C1 [Boland, Patrick Anthony; Kelly, Michael E.; Donlon, Noel E.; Bolger, Jarlath C.; Mehigan, Brian J.; McCormick, Paul H.; Larkin, John O.] St James Hosp, Dept Colorectal Surg, Dublin 8, Ireland.
C3 Trinity College Dublin
RP Boland, PA (通讯作者)，St James Hosp, Dept Colorectal Surg, Dublin 8, Ireland.
EM patrick.boland.1@ucdconnect.ie
RI Kelly, Michael E/AAF-1917-2021; Bolger, Jarlath/ABE-7206-2021
OI Kelly, Michael E/0000-0002-0757-6411; Boland,
   Patrick/0000-0002-5844-7695
CR [Anonymous], 2019, EXCELLENCE NIFHA PIC
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NR 48
TC 39
Z9 43
U1 0
U2 6
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0021-1265
EI 1863-4362
J9 IRISH J MED SCI
JI Irish J. Med. Sci.
PD FEB
PY 2021
VL 190
IS 1
BP 261
EP 267
DI 10.1007/s11845-020-02283-7
EA JUN 2020
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QA4RL
UT WOS:000543293200002
PM 32588378
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU O'Malley, QF
   Sims, JR
   Sandler, ML
   Spitzer, H
   Urken, ML
AF O'Malley, Quinn F.
   Sims, John R.
   Sandler, Mykayla L.
   Spitzer, Hannah
   Urken, Mark L.
TI The use of negative pressure wound therapy in the primary setting for
   high-risk head and neck surgery
SO AMERICAN JOURNAL OF OTOLARYNGOLOGY
LA English
DT Article
DE Negative pressure wound therapy; Negative pressure dressings;
   Vacuum-assisted wound closure; Head and neck; Otolaryngology
ID VACUUM-ASSISTED CLOSURE; FREE-FLAP RECONSTRUCTION; PECTORALIS MAJOR
   FLAP; PREOPERATIVE RADIOTHERAPY; MICROSURGICAL HEAD; COMPLICATIONS;
   MANAGEMENT; OUTCOMES; DEFECTS
AB Background: In head and neck surgery, dead space is typically managed by transferring a secondary pedicled flap or harvesting a larger composite flap with a muscular component. We demonstrate the novel use of prophylactic negative pressure wound therapy (NPWT) to obliterate dead space and reduce possible communication between the upper aerodigestive tract and the contents of the neck.
   Methods: We present a single-institutional case series of five patients with high-risk head and neck cancer treated with NPWT after ablative and reconstructive surgery to eliminate dead space following surgical resection.
   Results: All patients achieved successful wound closure following NPWT, which was applied in the secondary setting to combat infection in one patient and the primary setting to prophylactically eliminate dead space in four patients.
   Conclusion: NPWT can be used to treat unfilled dead space in the primary setting of head and neck ablative and reconstructive surgery and help to avoid wound healing problems as well as the need for secondary flap transfers.
C1 [O'Malley, Quinn F.; Sims, John R.; Sandler, Mykayla L.; Spitzer, Hannah; Urken, Mark L.] THANC Thyroid Head & Neck Canc Fdn, 10 Union Sq East,Suite 5B, New York, NY 10003 USA.
   [Sims, John R.; Urken, Mark L.] Mt Sinai Hosp, Dept Otolaryngol Head & Neck Surg, Icahn Sch Med, Mt Sinai Beth Israel, 10 Union Sq East,Suite 5B, New York, NY 10003 USA.
C3 Icahn School of Medicine at Mount Sinai
RP O'Malley, QF (通讯作者)，THANC Thyroid Head & Neck Canc Fdn, 10 Union Sq East,Suite 5B, New York, NY 10003 USA.
EM qomalley@thancfoundation.org
OI O'Malley, Quinn/0000-0003-2815-0417
FU Mount Sinai Health System
FX We thank the Mount Sinai Health System for its generous support of this
   research.
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NR 34
TC 4
Z9 5
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0196-0709
EI 1532-818X
J9 AM J OTOLARYNG
JI Am. J. Otolaryngol.
PD JUL-AUG
PY 2020
VL 41
IS 4
AR 102470
DI 10.1016/j.amjoto.2020.102470
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA MC5YR
UT WOS:000543362600017
PM 32299639
DA 2026-07-24
ER
PT J
AU Prokuski, V
   Strohl, A
AF Prokuski, Vanessa
   Strohl, Adam
TI Soft Tissue Coverage for Severe Infections
SO HAND CLINICS
LA English
DT Review
DE Infection; Wound; Coverage; Debridement; Flap
ID HYPERBARIC-OXYGEN THERAPY; UPPER EXTREMITY; RECONSTRUCTIVE LADDER;
   METHICILLIN-RESISTANT; HAND; DEFECTS; FLAPS
AB Coverage of soft tissue defects in the upper extremity caused by infection and debridement of infected tissue is a challenging problem. Treatment starts with prompt identification and eradication of infection, including antibiotics and extensive debridement. Optimizing the patient's medical and nutritional status can facilitate eradication of infection and wound healing. Coverage of soft tissue defects caused by infection and debridement demands consideration of many factors. Options include healing by primary or secondary intention, skin grafts, local flaps, and distant flaps. Negative pressure wound therapy and acellular dermal matrices can also aid in coverage.
C1 [Prokuski, Vanessa] Philadelphia Hand Shoulder Ctr Jefferson, Philadelphia, PA USA.
   [Prokuski, Vanessa] Orthoped Care Phys Network, 675 Paramt Dr,Suite 205, Raynham, MA 02767 USA.
   [Strohl, Adam] Thomas Jefferson Univ Hosp, Plast & Reconstruct Surg, Philadelphia Hand Shoulder Ctr, 834 Chestnut St,Suite G-114, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University
RP Strohl, A (通讯作者)，Thomas Jefferson Univ Hosp, Plast & Reconstruct Surg, Philadelphia Hand Shoulder Ctr, 834 Chestnut St,Suite G-114, Philadelphia, PA 19107 USA.
EM ABStrohl@handcenters.com
RI Strohl, Adam/NLN-7045-2025
OI Strohl, Adam/0000-0001-5671-9776
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NR 46
TC 4
Z9 9
U1 0
U2 34
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0712
EI 1558-1969
J9 HAND CLIN
JI Hand Clin.
PD AUG
PY 2020
VL 36
IS 3
BP 369
EP +
DI 10.1016/j.hcl.2020.03.011
PG 13
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA MC5ZB
UT WOS:000543363600013
PM 32586464
DA 2026-07-24
ER
PT J
AU Seidel, D
   Diedrich, S
   Herrle, F
   Thielemann, H
   Marusch, F
   Schirren, R
   Talaulicar, R
   Gehrig, T
   Lehwald-Tywuschik, N
   Glanemann, M
   Bunse, J
   Hüttemann, M
   Braumann, C
   Heizman, O
   Miserez, M
   Krönert, T
   Gretschel, S
   Lefering, R
AF Seidel, Dorthe
   Diedrich, Stephan
   Herrle, Florian
   Thielemann, Henry
   Marusch, Frank
   Schirren, Rebekka
   Talaulicar, Recca
   Gehrig, Tobias
   Lehwald-Tywuschik, Nadja
   Glanemann, Matthias
   Bunse, Joerg
   Huettemann, Martin
   Braumann, Chris
   Heizman, Oleg
   Miserez, Marc
   Kroenert, Thomas
   Gretschel, Stephan
   Lefering, Rolf
TI Negative Pressure Wound Therapy vs Conventional Wound Treatment in
   Subcutaneous Abdominal Wound Healing Impairment The SAWHI Randomized
   Clinical Trial
SO JAMA SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; QUALITY-OF-LIFE; RISK-FACTORS; SURGERY; GROIN;
   INFECTIONS; ALGINATE
AB IMPORTANCE Negative pressure wound therapy (NPWT) is an established treatment option, but there is no evidence of benefit for subcutaneous abdominal wound healing impairment (SAWHI).
   OBJECTIVE To evaluate the effectiveness and safety of NPWT for SAWHI after surgery in clinical practice.
   DESIGN, SETTING, AND PARTICIPANTS The multicenter, multinational, observer-blinded, randomized clinical SAWHI study enrolled patients between August 2, 2011, and January 31, 2018. The last follow-up date was June 11, 2018. The trial included 34 abdominal surgical departments of hospitals in Germany, Belgium, and the Netherlands, and 539 consecutive, compliant adult patients with SAWHI after surgery without fascia dehiscence were randomly assigned to the treatment arms in a 1:1 ratio stratified by study site and wound size using a centralized web-based tool. A total of 507 study participants (NPWT, 256; CWT, 251) were assessed for the primary end point in the modified intention-to-treat (ITT) population.
   INTERVENTIONS Negative pressure wound therapy and conventional wound treatment (CWT).
   MAIN OUTCOMES AND MEASURES The primary outcome was time until wound closure (delayed primary closure or by secondary intention) within 42 days. Safety analysis comprised the adverse events (AEs). Secondary outcomes included wound closure rate, quality of life (SF-36), pain, and patient satisfaction.
   RESULTS Of the 507 study participants included in the modified ITT population, 287 were men (56.6%) (NPWT, 155 [60.5%] and CWT, 132 [52.6%)) and 220 were women (43.4%) (NPWT, 101[39.5%) and CWT 119 [47.4%)). The median (IQR) age of the participants was 66 (18) years in the NPWT arm and 66 (20) years in the CWT arm. Mean time to wound closure was significantly shorter in the NPWT arm (36.1days) than in the CWT arm (39.1days) (difference, 3.0 days; 95% CI 1.6-4.4; P < .001). Wound closure rate within 42 days was significantly higher with NPWT (35.9%) than with CWT (21.5%) (difference, 14.4%; 95% CI, 6.6%-22.2%; P < .001). In the therapy-compliant population, excluding study participants with unauthorized treatment changes (NPWT, 22; CWT, 50), the risk for wound-related AEs was higher in the NPWT arm (risk ratio, 1.51; 95% CI, 0.99-2.35).
   CONCLUSIONS AND RELEVANCE Negative pressure wound therapy is an effective treatment option for SAWHI after surgery; however, it causes more wound-related AEs.
C1 [Seidel, Dorthe; Lefering, Rolf] Univ Witten Herdecke, Inst Res Operat Med, Cologne, Germany.
   [Diedrich, Stephan] Greifswald Univ Hosp, Dept Gen Surg Visceral Thorac & Vasc Surg, Greifswald, Germany.
   [Herrle, Florian] Heidelberg Univ, Med Fac Mannheim, Dept Surg, Mannheim, Germany.
   [Thielemann, Henry] Unfallkrankenhaus Berlin, Dept Gen & Abdominal Surg, Berlin, Germany.
   [Marusch, Frank] Klinikum Ernst von Bergmann Gemeinnutzige GmbH, Dept Gen & Visceral Surg, Potsdam, Germany.
   [Schirren, Rebekka] Techn Univ Munich, Hosp Rechts Isar, Dept & Polyclin Surg, Munich, Germany.
   [Talaulicar, Recca] Univ Med Ctr Gottingen, Dept Gen Visceral & Pediat Surg, Gottingen, Germany.
   [Gehrig, Tobias] GRN Klin Sinsheim, Dept Gen & Visceral Surg, Sinsheim, Germany.
   [Lehwald-Tywuschik, Nadja] Hosp Heinrich Heine Univ Dusseldorf, Dept Surg A, Dusseldorf, Germany.
   [Glanemann, Matthias] Saarland Univ, Dept Gen Visceral Vasc & Pediat Surg, Homburg, Germany.
   [Bunse, Joerg] Sana Klinikum Lichtenberg, Dept Gen & Visceral Surg, Berlin, Germany.
   [Huettemann, Martin] Evangel Krankenhaus, Dept Gen & Visceral Surg, Oberhausen, Germany.
   [Braumann, Chris] St Josef Hosp Bochum, Dept Gen & Visceral Surg, Bochum, Germany.
   [Heizman, Oleg] Agaples Diakonieklinikum Rotenburg Gemeinnutzige, Dept Gen Visceral & Thorac Surg, Rotenburg, Wumme, Germany.
   [Miserez, Marc] Univ Hosp Katholieke Univ Leuven, Dept Abdominal Surg, Leuven, Belgium.
   [Kroenert, Thomas] Thuringen Kliniken Georgius Agr, Dept Vasc Surg, Ctr Vasc Med, Saalfeld, Germany.
   [Gretschel, Stephan] Univ Hosp Neuruppin, Dept Gen & Visceral Surg, Brandenburg Med Sch, Neuruppin, Germany.
C3 Witten Herdecke University; Ruprecht Karls University Heidelberg;
   Klinikum Ernst von Bergmann; Technical University of Munich; Heinrich
   Heine University Dusseldorf; Heinrich Heine University Dusseldorf
   Hospital; Universitatsklinikum des Saarlandes; Ruhr University Bochum
RP Seidel, D (通讯作者)，Univ Witten Herdecke, Inst Forsch Operat Med IFOM, Ostmerheimerstr 200 Haus 38, D-51109 Cologne, Germany.
EM dortheseidel@gmx.de
OI , marc/0000-0002-7047-6114
FU Kinetic Concepts Incorporated, an Acelity company
FX The SAWHI-study was funded by the manufacturer Kinetic Concepts
   Incorporated, an Acelity company, which included the financing of
   personnel and material resources for planning, conduct, analysis and
   report of the study. In addition, the manufacturer provided the vacuum
   assisted closure (VAC) therapy devices and associated consumable
   supplies.
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NR 26
TC 52
Z9 62
U1 2
U2 8
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6254
EI 2168-6262
J9 JAMA SURG
JI JAMA Surg.
PD JUN
PY 2020
VL 155
IS 6
BP 469
EP 478
DI 10.1001/jamasurg.2020.0414
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA MD6IU
UT WOS:000544076100008
PM 32293657
OA Green Accepted, Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Cheng, YL
   Zhou, ZD
   Hu, H
   Li, WB
   Liu, Y
   Xia, ZH
   Deng, CL
   Mao, GY
   Yi, L
   Liu, XD
   Yang, SL
   Zheng, JH
   Guo, F
AF Cheng, Yulong
   Zhou, Zengding
   Hu, Huan
   Li, Wenbo
   Liu, Yi
   Xia, Zihuan
   Deng, Chenliang
   Mao, Guangyu
   Yi, Lei
   Liu, Xiangdong
   Yang, Songlin
   Zheng, Jianghong
   Guo, Feng
TI An Application of a Negative-Pressure Wound Dressing for Partial- or
   Full-Thickness Burn Wounds
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE negative-pressure wound therapy; negative pressure; dressing;
   partial-thickness burn; full-thickness burn
ID VACUUM-ASSISTED CLOSURE; THERAPY
AB Negative-pressure wound therapy is widely used in burn populations. Traditionally, negative-pressure devices use persistent vacuum suction, requiring a longer hospital stay. In this study, we applied a novel negative-pressure wound dressing for burn wounds, which eliminates the hospital stay. The medical records of 39 patients with partial-/full-thickness burns treated by negative-pressure wound dressing were retrospectively analyzed. The average burn area, burn degree, healing duration, cost, and incidents during treatment were determined and compared with previous data for conventional therapies. In conclusion, for patients diagnosed with partial-thickness or full-thickness burns and a burn area <34.6 +/- 2.21 cm(2), the negative-pressure wound dressing is a reliable option, especially for burnt children. Moreover, the negative-pressure wound dressing treatment was not only much cheaper than conventional therapies, but also eliminated hospital stay in patients with small-area deep burn wounds.
C1 [Cheng, Yulong; Hu, Huan; Li, Wenbo; Liu, Yi; Xia, Zihuan; Deng, Chenliang; Mao, Guangyu; Liu, Xiangdong; Yang, Songlin; Zheng, Jianghong; Guo, Feng] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp Shanghai 6, Shanghai, Peoples R China.
   [Zhou, Zengding; Yi, Lei] Shanghai Jiao Tong Univ, Rui Jin Hosp, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Zheng, JH; Guo, F (通讯作者)，Shanghai Jiao Tong Univ, Affiliated Peoples Hosp Shanghai 6, Dept Plast Surg, 600 Yishan Rd, Shanghai 200233, Peoples R China.
EM zihsh68@sohu.com; guofengburn@aliyun.com
RI Yi, Lei/AAI-6290-2020; li, wenbo/AAF-3106-2019
FU National Science Foundation of China [81772078, 81571907, 81971832];
   National Science Foundation of Shanghai [19ZR1432100]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by grants from National Science Foundation of China (NO.
   81772078, 81571907 and 81971832), and by the National Science Foundation
   of Shanghai (19ZR1432100).
CR Adkesson MJ, 2007, JAVMA-J AM VET MED A, V231, P1249, DOI 10.2460/javma.231.8.1249
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NR 19
TC 8
Z9 8
U1 0
U2 52
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2021
VL 20
IS 3
BP 257
EP 262
AR 1534734620933439
DI 10.1177/1534734620933439
EA JUN 2020
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA TY5OX
UT WOS:000544266200001
PM 32594807
DA 2026-07-24
ER
PT J
AU Delarestaghi, MM
   Ahmadi, A
   Firouzabadi, FD
   Roomiani, M
   Firouzabadi, MD
   Faham, Z
AF Delarestaghi, Mojtaba Maleki
   Ahmadi, Aslan
   Firouzabadi, Fatemeh Dehghani
   Roomiani, Maryam
   Firouzabadi, Mohammad Dehghani
   Faham, Zhaleh
TI Effect of Low-Pressure Drainage Suction on Pharyngocutaneous Fistula
   After Total Laryngectomy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE surgical procedures; operative; drainage; negative-pressure wound
   therapy; pharyngocutaneous fistula
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; MULTIVARIATE-ANALYSIS; SALVAGE
   LARYNGECTOMY; PRIMARY RADIOTHERAPY; PREDISPOSING FACTORS; WOUND THERAPY;
   METAANALYSIS; HEAD
AB Objective: Pharyngocutaneous fistula (PCF) is one of the most severe multifactorial complications following laryngectomy. The current study aimed at determining the effect of a low-pressure vacuum drain on the incidence of PCF after total laryngectomy. Methods: The current randomized clinical trial was conducted on 35 patients undergoing total laryngectomy in Hazrat Rasoul Akram and Firoozgar hospitals in Tehran, Iran. The subjects were divided into the vacuum drain (n = 15) and control (without vacuum drain) (n = 20) groups. The incidence of PCF and the recovery time were recorded. Results: The rate of PCF formation from the stoma and wound edges was significantly lower in the low-pressure vacuum drain group than in the control group (6.7% vs 40%) (P < .05). There was no significant difference between the groups in time to recovery from PCF. Conclusion: The low-pressure vacuum drain method is effective in reducing the incidence of PCF after total laryngectomy.
C1 [Delarestaghi, Mojtaba Maleki] Iran Univ Med Sci, Firoozgar Hosp, Five Senses Inst, Otolaryngol,ENT & Head & Neck Res Ctr & Dept, Tehran, Iran.
   [Ahmadi, Aslan] Iran Univ Med Sci, ENT & Head & Neck Res Ctr & Dept, Otolaryngol, Tehran, Iran.
   [Firouzabadi, Fatemeh Dehghani; Roomiani, Maryam; Firouzabadi, Mohammad Dehghani; Faham, Zhaleh] Iran Univ Med Sci, ENT & Head & Neck Res Ctr & Dept, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Iran University of Medical Sciences
RP Roomiani, M; Faham, Z (通讯作者)，Iran Univ Med Sci, ENT & Head & Neck Res Ctr & Dept, Tehran, Iran.
EM maryamroomiani3@gmail.com; zhalehfaham@gmail.com
RI ; Ahmadi, Aslan/P-6152-2018
OI Maleki Delarestaghi, Mojtaba/0000-0002-9703-2425; Dehghani Firouzabadi,
   Fatemeh/0000-0002-2665-3910; 
CR Aarts MCJ, 2011, OTOLARYNG HEAD NECK, V144, P5, DOI 10.1177/0194599810390914
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NR 30
TC 7
Z9 8
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-4894
EI 1943-572X
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2021
VL 130
IS 1
BP 32
EP 37
AR 0003489420934506
DI 10.1177/0003489420934506
EA JUN 2020
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA PG7KF
UT WOS:000545805600001
PM 32597686
DA 2026-07-24
ER
PT J
AU Fiori, F
   Ferrara, F
   Gobatti, D
   Gentile, D
   Stella, M
AF Fiori, Federico
   Ferrara, Francesco
   Gobatti, Davide
   Gentile, Daniele
   Stella, Marco
TI Surgical treatment of diastasis recti: the importance of an overall view
   of the problem
SO HERNIA
LA English
DT Article
DE Diastasis recti; Surgery; Minimally invasive; Abdominal wall; Hernia
ID BODY-MASS INDEX; WOUND COMPLICATIONS; MUSCLE DIASTASIS; VENTRAL HERNIA;
   RISK-FACTORS; MESH REPAIR; ABDOMINOPLASTY; SURGERY; PREVALENCE;
   ABDOMINIS
AB Purpose Diastasis recti (DR) is characterized by an alteration of the linea alba with increased inter-recti distance (IRD). It is more frequent in females, and when symptomatic or associated with midline hernia it needs to be surgically repaired. This retrospective study aims to demonstrate how an overall approach to DR leads to good results in terms of functional and morphological outcomes and quality of life (QoL). Methods From January 2018 to December 2019, 94 patients were operated for DR > 50 mm, with or without midline hernias. Three different surgical approaches were used: complete laparoabdominoplasty, laparominiabdominoplasty and minimally invasive (endoscopic) technique. QoL was assessed with the EuraHS-QoL tool. Results All patients were female except two males. We performed 26 endoscopic treatments (27.7%), 39 laparoabdominoplasties (41.5%) and 29 laparominiabdominoplasties (umbilical float procedure) (30.9%). The total median operative time was 160 min. No intraoperative complications were registered. In three (4.2%) cases, major surgical complications occurred, all after open operations. In 13 open surgery cases, vacuum-assisted closure (VAC) therapy was used to repair the cutaneous ischemic defect. No recurrence was registered to date. Minimally invasive surgery showed fewer complications and lower hospital stay than the open approach. The QoL was significantly improved. Conclusion Our experience shows the importance of an overall view of the functional and cosmetic impairment created by DR. The surgeon should obtain an optimal repair of the function, by open or minimally invasive surgery, also considering the morphological aspects, which are very important for the patients in terms of QoL.
C1 [Fiori, Federico; Ferrara, Francesco; Gobatti, Davide; Gentile, Daniele; Stella, Marco] San Carlo Borromeo Hosp, Unit Gen Surg, Dept Surg, ASST Santi Paolo & Carlo, Via Pio II 3, I-20153 Milan, Italy.
C3 San Carlo Borromeo Hospital
RP Ferrara, F (通讯作者)，San Carlo Borromeo Hosp, Unit Gen Surg, Dept Surg, ASST Santi Paolo & Carlo, Via Pio II 3, I-20153 Milan, Italy.
EM frr.fra@gmail.com
RI ; Ferrara, Francesco/A-4559-2014; Ferrara, Francesco/A-4559-2014
OI Gobatti, Davide/0000-0002-1674-5168; Ferrara,
   Francesco/0000-0002-8208-1945; Ferrara, Francesco/0000-0001-9298-6783
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NR 57
TC 27
Z9 31
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD AUG
PY 2021
VL 25
IS 4
BP 871
EP 882
DI 10.1007/s10029-020-02252-0
EA JUN 2020
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UC6MV
UT WOS:000546167300001
PM 32564225
DA 2026-07-24
ER
PT J
AU Okuya, K
   Takemasa, I
   Tsuruma, T
   Noda, A
   Sasaki, K
   Ueki, T
   Mukaiya, M
   Saito, K
   Okita, K
   Nishidate, T
   Akizuki, E
   Hamabe, A
   Ishii, M
AF Okuya, Koichi
   Takemasa, Ichiro
   Tsuruma, Tetsuhiro
   Noda, Ai
   Sasaki, Kenichi
   Ueki, Tomomi
   Mukaiya, Mitsuhiro
   Saito, Keita
   Okita, Kenji
   Nishidate, Toshihiko
   Akizuki, Emi
   Hamabe, Atsushi
   Ishii, Masayuki
TI Evaluation of negative-pressure wound therapy for surgical site
   infections after ileostomy closure in colorectal cancer patients: a
   prospective multicenter study
SO SURGERY TODAY
LA English
DT Article
DE Surgical site infection; Ileostomy closure; Negative-pressure wound
   therapy
ID RANDOMIZED CLINICAL-TRIAL; LOOP ILEOSTOMY; SKIN CLOSURE; OPEN-LABEL;
   RISK; MORBIDITY; SURGERY; REVERSAL; PREVENTION; OUTCOMES
AB Purpose Surgical site infection (SSI) occurs at a high rate after ileostomy closure. The effect of preventive negative-pressure wound therapy (NPWT) on SSI development in closed wounds remains controversial. We conducted a prospective multicenter study to evaluate the usefulness of preventive NPWT for SSI after ileostomy closure.
   Methods From January 2018 to November 2018, 50 patients who underwent closure of ileostomy created after surgery for colorectal cancer participated in this study. An NPWT device was applied to each wound immediately after surgery and then treatment was continued for 3 days. The primary endpoint was 30-day SSI, and the secondary endpoints were the incidence of seroma, hematoma, and adverse events related to NPWT.
   Results No patients developed SSI, seroma, or hematoma. Adverse events that may have been causally linked with NPWT were contact dermatitis in two patients and wound pain in one patient, and there were no cases of discontinuation or decompression of NPWT.
   Conclusion The use of NPWT following ileostomy closure may be useful for reducing the development of SSI in colorectal cancer patients. This is a prospective multicenter pilot study and we are planning a comparative study based on these successful results.
C1 [Okuya, Koichi; Takemasa, Ichiro; Okita, Kenji; Nishidate, Toshihiko; Akizuki, Emi; Hamabe, Atsushi; Ishii, Masayuki] Sapporo Med Univ, Dept Surg Surg Oncol & Sci, Chuo Ku, S1,W16, Sapporo, Hokkaido 0608543, Japan.
   [Tsuruma, Tetsuhiro; Ueki, Tomomi] JR Sapporo Hosp, Dept Surg, Chuo Ku, N3,E1, Sapporo, Hokkaido 0600033, Japan.
   [Noda, Ai; Ueki, Tomomi; Mukaiya, Mitsuhiro] Otaru Ekisaikai Hosp, Dept Surg, 1-4-1 Inaho, Otaru, Hokkaido 0470032, Japan.
   [Sasaki, Kenichi; Saito, Keita] Muroran City Gen Hosp, Dept Surg, 3-8-1 Yamate Cho, Muroran, Hokkaido 0518512, Japan.
C3 Sapporo Medical University
RP Takemasa, I (通讯作者)，Sapporo Med Univ, Dept Surg Surg Oncol & Sci, Chuo Ku, S1,W16, Sapporo, Hokkaido 0608543, Japan.
EM itakemasa@sapmed.ac.jp
RI Nishidate, Toshihiko/AFP-4588-2022
FU Sapporo Medical University
FX This research was carried out using research funds from the Sapporo
   Medical University. There was no financial support from any companies.
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NR 29
TC 10
Z9 10
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD DEC
PY 2020
VL 50
IS 12
BP 1687
EP 1693
DI 10.1007/s00595-020-02068-6
EA JUL 2020
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OT7EC
UT WOS:000546767500002
PM 32638132
DA 2026-07-24
ER
PT J
AU Jiang, XY
   Li, N
   Yuan, Y
   Yang, C
   Chen, Y
   Ma, Y
   Wang, JB
   Du, DY
   Boey, J
   Armstrong, DG
   Deng, WQ
AF Jiang, Xiaoyan
   Li, Ning
   Yuan, Yi
   Yang, Cheng
   Chen, Yan
   Ma, Yu
   Wang, Jianbai
   Du, Dingyuan
   Boey, Johnson
   Armstrong, David G.
   Deng, Wuquan
TI Limb Salvage and Prevention of Ulcer Recurrence in a Chronic Refractory
   Diabetic Foot Osteomyelitis
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE diabetic foot ulcer; osteomyelitis; antibiotic-loaded bone cement;
   autologous platelet-rich gel; negative-pressure wound therapy; of
   floading footwear
ID PLATELET-RICH PLASMA; PLANTAR PRESSURE; MANAGEMENT; ISCHEMIA; INFECTION;
   OUTCOMES; PATIENT; CARE
AB Biomechanical changes caused by structural foot deformities predispose patients to plantar ulceration. Plantar ulcer recurrence often leads to osteomyelitis, which is more commonly observed in patients with diabetes. Once the infection of diabetic foot ulcer (DFU) spreads and is complicated by osteomyelitis, treatment becomes more complicated and difficult. Osteomyelitis treatment remains challenging because of low drug concentration within the tissue caused by poor circulation and inadequate localized nutrition. Moreover, tissues around plantar ulcers are fewer and are thin, making the formation of granulation tissues difficult due to elevated plantar pressure. Furthermore, the skin around the wound is excessively keratinized, and the epidermis is hard to regenerate. Meanwhile, skin grafting at that site is often not successful due to poor blood circulation. Therefore, it is technically challenging to manage diabetic pressure plantar ulcer with osteomyelitis and prevent its recurrence. Here, we present a case of chronic DFU complicated by osteomyelitis due to foot deformity. The ulcer was successfully healed using advanced wound repair technology comprising of surgical bone resection, vancomycin-loaded bone cement implant, negative - pressure wound therapy, and autologous platelet -rich gel. Subsequently, preventive foot care with custom-made of floading footwear was prescribed. The plantar ulcer did not recur and improvement in biomechanical parameters was observed after the intervention. This case represents an effective and comprehensive management strategy for limb salvage and pre- vention in patients with complicated foot conditions.
C1 [Jiang, Xiaoyan; Li, Ning; Yuan, Yi; Yang, Cheng; Chen, Yan; Ma, Yu; Deng, Wuquan] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol & Nephrol,Diabet Foot Ctr, Chongqing, Peoples R China.
   [Wang, Jianbai; Du, Dingyuan] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Traumatol,Diabet Foot Ctr, Chongqing, Peoples R China.
   [Boey, Johnson] Natl Univ Singapore Hosp, Dept Podiatry, Singapore, Singapore.
   [Armstrong, David G.] Univ Southern Calif, Keck Sch Med, Los Angeles, CA 90007 USA.
C3 Chongqing University; Chongqing University; National University of
   Singapore; University of Southern California
RP Deng, WQ (通讯作者)，Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol & Nephrol, 1 Jiankang Rd, Chongqing 400014, Peoples R China.
EM wuquandeng@gmail.com
RI Boey, Johnson/AAR-2853-2020
OI Boey, Johnson/0000-0001-9466-7241
FU Fundamental Research Funds for the Central Universities at Chongqing
   University [2019CDYGYB020]; Joint Medical Research Programs for
   Chongqing Municipal Science and Technology Bureau and Health Commission
   [2019MSXM028]; National Center for Advancing Translational Sciences
   [UL1TR001855] Funding Source: NIH RePORTER
FX This study was supported by the Fundamental Research Funds for the
   Central Universities at Chongqing University (Grant No.2019CDYGYB020)
   and the Joint Medical Research Programs for Chongqing Municipal Science
   and Technology Bureau and Health Commission (Grant No.2019MSXM028)
   awarded to Dr. Wuquan Deng and Xiaoyan Jiang.
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NR 37
TC 13
Z9 18
U1 0
U2 18
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 2289
EP 2296
DI 10.2147/DMSO.S254586
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MI5KM
UT WOS:000547446600002
PM 32636663
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kapukaya, R
   Ciloglu, O
AF Kapukaya, Rana
   Ciloglu, Osman
TI Treatment of chronic wounds with polyurethane sponges impregnated with
   boric acid particles: A randomised controlled trial
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE boric acid particle; chronic wound; negative pressure wound therapy
ID SILVER; BORON
AB The objective of this study was to investigate the effectiveness of the sponge with boric acid particles combined with the negative pressure wound treatment (NPWT) system for chronic wounds with tissue defects. Our study was designed as a prospective randomised study. One hundred patients who were planned to have NPWT due to chronic wounds were included in this study from Orthopaedics and Traumatology and Plastic Surgery clinics. Patients were divided into two groups. In the first group, a new method, boric acid impregnated sponge, combined with the NPWT system, was used, and in the second group, sponge with silver nitrate was used. Besides the wide-broad spectrum antibacterial properties of silver nitrate, the antimicrobial, angiogenetic, and epithelial effects of boric acid were aimed to investigate by macroscopically and histopathologically. Thirty-six patients in the silver nitrate group and 44 patients in the boric acid group completed the study. A decrease in wound size and granulation was observed in both groups. Macroscopically, a decrease in wound size reduction, epithelialization and granulation were more prominent in the first group in which boric acid impregnated sponge was used than the second group in which silver sponge was used. Moreover, microscopically, the number of fibroblasts, collagen synthesis, and angiogenesis were significantly increased in Group 1. In this clinical study, the broad-spectrum antimicrobial properties of boric acid and its positive effect on the cells responsible for wound healing were found to be more pronounced compared to silver nitrate sponges. A combination of boric acid sponges with the NPWT system may be an alternative method for chronic wounds.
C1 [Kapukaya, Rana] Univ Hlth Sci, Dept Plast & Reconstruct Surg, Adana City Res & Training Hosp, Mithat Ozhan Bulvari Kula Mah 1 Yuregir, Adana, Turkey.
   [Ciloglu, Osman] Univ Hlth Sci, Dept Orthopaed & Traumatol, Adana City Res & Training Hosp, Adana, Turkey.
C3 University of Health Sciences Turkey; University of Health Sciences
   Turkey
RP Ciloglu, O (通讯作者)，Univ Hlth Sci, Dept Plast & Reconstruct Surg, Adana City Res & Training Hosp, Mithat Ozhan Bulvari Kula Mah 1 Yuregir, Adana, Turkey.
EM osmanciloglu@gmail.com
RI KAPUKAYA, RANA/HKE-5389-2023; ciloglu, osman/QKY-0989-2026
OI KAPUKAYA, RANA/0000-0001-9709-328X; Ciloglu, Osman/0000-0002-3660-3511; 
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NR 22
TC 18
Z9 24
U1 2
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1159
EP 1165
DI 10.1111/iwj.13463
EA JUL 2020
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000548143200001
PM 32662209
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Li, TT
   Wang, GQ
   Yin, P
   Li, ZR
   Zhang, LH
   Tang, PF
AF Li, Tongtong
   Wang, Guoqi
   Yin, Peng
   Li, Zhirui
   Zhang, Lihai
   Tang, Peifu
TI Adaptive expression of biofilm regulators and adhesion factors of
   Staphylococcus aureus during acute wound infection under the
   treatment of negative pressure wound therapy in vivo
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE negative pressure wound therapy; biofilm; bacterial colonization;
   Staphylococcus aureus; acute wound
ID VACUUM-ASSISTED CLOSURE; DETERMINANTS; MECHANISMS; GROWTH; MODEL
AB Negative pressure wound therapy (NPWT) is gaining acceptance as a physical therapy for a wide variety of infected wounds. To gain insight into the response of bacteria to NPWTin vivo, the adaptive expression of biofilm regulators and adhesion factors ofStaphylococcus aureus (S. aureus), the most frequently isolated pathogen in the clinic, during acute wound infection was investigated. A 3 cm full-thickness dermal wound was created on each side of a rabbit back and inoculated with green fluorescent protein-labeledS. aureus. NPWT was initiated at 6 h post inoculation, with the wound on the contralateral side as the untreated self-control. The wounds were subjected to a 28 day observation period. Histological analysis, laser scanning confocal microscopy and scanning electron microscopy revealed a transition ofS. aureusto a free-living phenotype in tissues treated with NPWT, compared with microcolonies in untreated wounds. Viable bacteria counts showed a modest reduction in the bioburden of NPWT group on day 8 (P<0.001), with similar to 1x10(6)colony-forming units/g tissue. Transcript analysis of biofilm- and colonization-related genes were investigated using reverse transcription-quantitative PCR on postoperative days 1, 2, 4 and 8. The poly-beta-1,6-N-acetyl-D-glucosamine synthase locus and holin-like protein CidA/antiholin-like protein LrgA network were less active in the NPWT group compared with the untreated control group. Accordingly, the expression profile switched to an elevated expression of the adhesive factors UDP-phosphate N-acetylglucosaminyl 1-phosphate transferase (at days 0-4) and fibronectin-binding protein A and iron-regulated surface determinant protein A at >4 days during both stages of colonization. Meanwhile, low expression levels of the effector molecule (RNAIII) of the accessory gene regulator type I (agr) system was detected in NPWT group, suggesting that the bacterial density in NPWT-treated wounds was under the threshold foragractivation, thus not leading to an active and invasive infection. The wounds treated by NPWT healed completely on day 28, compared with an average of an 8.11% defect area in the control group (P<0.001). The results of the current study indicated thatS. aureusresponds to NPWT by regulating gene expression, manifesting a decrease in biofilm formation and an increase in bacterial colonizationin vivo, which potentially benefits the wound repair and healing process.
C1 [Li, Tongtong] Tianjin Hosp, Dept Orthoped, Tianjin 300211, Peoples R China.
   [Wang, Guoqi] Chinese Peoples Liberat Army PLA Gen Hosp, Dept Pediat, Beijing 100853, Peoples R China.
   [Yin, Peng] Beijing Chao Yang Hosp, Dept Orthoped, Beijing 100043, Peoples R China.
   [Li, Zhirui; Zhang, Lihai; Tang, Peifu] Chinese Peoples Liberat Army PLA Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
C3 Tianjin University; Chinese People's Liberation Army General Hospital;
   Capital Medical University; Chinese People's Liberation Army General
   Hospital
RP Tang, PF (通讯作者)，Chinese Peoples Liberat Army PLA Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM tangpeifu301@sina.cn
RI Li, Zhirui/OJT-0490-2025
FU National Natural Science Foundation of China [81472112]
FX The present study was supported by the National Natural Science
   Foundation of China (grant no. 81472112).
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NR 42
TC 8
Z9 10
U1 0
U2 14
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JUL
PY 2020
VL 20
IS 1
BP 512
EP 520
DI 10.3892/etm.2020.8679
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA MM0YU
UT WOS:000549886400068
PM 32509022
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Joomun, MU
   Li, ZY
   Xue, DT
   Shao, HW
   Pan, ZJ
AF Joomun, Muhammad Umar
   Li, Zhiya
   Xue, Deting
   Shao, Huawei
   Pan, Zhijun
TI Idiopathic necrotizing fasciitis following fracture fixation A case
   report
SO MEDICINE
LA English
DT Article
DE diabetes mellitus; idiopathic; intertrochanteric fracture; necrotizing
   fasciitis; wound management
ID SOFT-TISSUE INFECTIONS; DIAGNOSIS; MORTALITY; SCORE
AB Introduction: Idiopathic necrotizing fasciitis (NF) is an infrequent, highly lethal skin infection that spreads rapidly, marked by fascia and subcutaneous tissue necrosis. It occurs in the absence of a known causative factor. Its emergence after sterile orthopedic fixation with unexpected spread to the abdomen may turn to be challenging both as a medical and surgical emergency. Patient concerns: A 56-year-old diabetic female presented with multiple fractures. After open reduction and internal fixation (ORIF) with iliac crest grafting of hip fracture, she developed incisional NF which later spread to the abdomen. Diagnosis: Post-ORIF of hip fracture complicated with idiopathic NF and abdominal spread. Interventions: She underwent emergency debridements with negative pressure wound therapy and broad-spectrum intravenous antibiotic therapy. After granulation, the wounds were closed with skin flaps and grafts with antibiotic beads. When the NF spread to the abdomen, additional debridements during abdominal explorations were performed. Outcomes: The patient was initially stable with promising healings of the wounds. Later, the patient suddenly developed a high fever and severe abdominal pain. Ultrasound revealed that NF emerged unexpectedly in the right lower abdomen. The causative agent of the NF remained undetected. Despite all the extensive treatments, the patient's condition deteriorated rapidly. She died of septic shock and multiple organ failure. Conclusion: The idiopathic NF may still potentially occur after a clean ORIF of the hip region. The implementation of intensive guideline-based treatments may show improvements, but the risk of unexpected NF spread to the abdomen should be anticipated, which may increase the mortality rates in diabetic or immunocompromised patients.
C1 [Joomun, Muhammad Umar; Xue, Deting; Pan, Zhijun] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthopaed, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China.
   [Li, Zhiya] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Emergency, Guangzhou, Guangdong, Peoples R China.
   [Shao, Huawei] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Burns, 88 Jiefang Rd, Hangzhou, Zhejiang, Peoples R China.
   [Shao, Huawei] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Wound Ctr, 88 Jiefang Rd, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Guangzhou University of Chinese Medicine; Zhejiang
   University; Zhejiang University
RP Pan, ZJ (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthopaed, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China.
EM zrpzj@zju.edu.cn
RI shao, huawei/LDF-8346-2024; Pan, Zhijun/AAD-6547-2022
OI JOOMUN, MUHAMMAD UMAR/0000-0002-3956-9531
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NR 25
TC 2
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN
PY 2020
VL 99
IS 26
AR e20874
DI 10.1097/MD.0000000000020874
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MM1AE
UT WOS:000549890000069
PM 32590794
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Bai, XG
   Wang, J
   Li, X
   Li, W
   Xu, J
AF Bai, Xiao-gang
   Wang, Jing
   Li, Xia
   Li, Wei
   Xu, Jie
TI A protocol of systematic review and meta-analysis of continuous vacuum
   sealing drainage for diabetic foot ulcer
SO MEDICINE
LA English
DT Article
DE continuous vacuum sealing drainage; diabetic foot ulcer; effectiveness;
   randomized controlled trial; safety
ID PREVALENCE; MELLITUS; BIAS
AB Background : Although continuous vacuum sealing drainage (CVSD) is often reported for the management of diabetic foot ulcer (DFU), its effectiveness has been evaluated primarily via clinical outcomes with limited attention. This study will aim to assess the effectiveness of CVSD for the treatment of patients with DFU. Methods: We will carry out a search in Cochrane Library, MEDLINE, Embase, CINAHL, PsycINFO, Web of Science, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from their inceptions to the March 1, 2020. We will exert the searches in those electronic databases without restrictions of language, and the use of validated filters to obtain eligible studies. In addition to the search in electronic databases, we will retrieve studies from conference proceedings, and reference lists of included trials. We will use Cochrane risk of bias tool to assess study quality for each eligible study. All statistical analysis will be conducted using RevMan 5.3 software. Results: This study will systematically summarize the most present evidence to assess the effectiveness and safety of CVSD for the management of DFU. Conclusion: The results from this study will contribute to obtain a genuine understanding of perspective from evidence-based medicine and a scientific basis for the effectiveness and safety of CVSD for the treatment of DFU. PROSPERO registration number: PROSPERO CRD42020170723.
C1 [Bai, Xiao-gang; Wang, Jing; Li, Xia; Li, Wei; Xu, Jie] Yanan Univ, Dept Endocrine & Metab, Affiliated Hosp, 43 Beida St, Yanan 716000, Shaanxi, Peoples R China.
C3 Yanan University
RP Li, X (通讯作者)，Yanan Univ, Dept Endocrine & Metab, Affiliated Hosp, 43 Beida St, Yanan 716000, Shaanxi, Peoples R China.
EM douzeke38@163.com
FU Yan'an Diabetes Prevention Research and Technology Innovation Team
   [2015CXTD-09]
FX This study was supported by Yan'an Diabetes Prevention Research and
   Technology Innovation Team (2015CXTD-09). The supporter was not allowed
   to involve in any sections of this study.
CR [Anonymous], 2019, IDF DIABETES ATLAS 9
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NR 24
TC 3
Z9 4
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN
PY 2020
VL 99
IS 25
AR e20541
DI 10.1097/MD.0000000000020541
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MM1BW
UT WOS:000549894500023
PM 32569175
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Palmieri, B
   Vadalà, M
   Laurino, C
AF Palmieri, Beniamino
   Vadala, Maria
   Laurino, Carmen
TI Electromedical devices in wound healing management: a narrative review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE biophotonic therapy; electromedical devices; electrotherapy; PEMF;
   phototherapy; pressure therapy; wound healing
ID LEVEL LASER THERAPY; INTERMITTENT PNEUMATIC COMPRESSION;
   ELECTROMAGNETIC-FIELD THERAPY; VENOUS LEG ULCERS;
   ELECTRICAL-STIMULATION; LIGHT THERAPY; FREQUENCY ULTRASOUND; PRESSURE
   ULCERS; PULSED CURRENT; GROWTH-FACTOR
AB Wound healing is the sum of physiological sequential steps, leading to skin restoration. However, in some conditions, such as diabetes, pressure ulcers (PU) and venous legs ulcers (VLU), healing is a major challenge and requires multiple strategies. In this context, some electromedical devices may accelerate and/or support wound healing, modulating the inflammatory, proliferation (granulation) and tissue-remodelling phases. This review describes some helpful electromedical devices including: ultrasonic-assisted wound debridement; electrotherapy; combined ultrasound and electric field stimulation; low-frequency pulsed electromagnetic fields; phototherapy (for example, laser therapy and light-emitting diode (LED) therapy); biophotonic therapies, and pressure therapies (for example, negative pressure wound therapy, and high pressure and intermittent pneumatic compression) The review focuses on the evidence-based medicine and adequate clinical trial design in relation to these devices.
C1 [Palmieri, Beniamino; Vadala, Maria; Laurino, Carmen] Univ Modena & Reggio Emilia, Dept Gen Surg & Surg Specialties, Surg Clin, Med Sch, Via Pozzo 71, I-41124 Modena, Italy.
   [Palmieri, Beniamino; Vadala, Maria; Laurino, Carmen] Second Opin Med Network, Via Ciro Bisi 125, Modena, Italy.
C3 Universita di Modena e Reggio Emilia
RP Vadalà, M (通讯作者)，Univ Modena & Reggio Emilia, Dept Gen Surg & Surg Specialties, Surg Clin, Med Sch, Via Pozzo 71, I-41124 Modena, Italy.; Vadalà, M (通讯作者)，Second Opin Med Network, Via Ciro Bisi 125, Modena, Italy.
EM mary.vadala@gmail.com
RI /K-3886-2016
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NR 89
TC 8
Z9 14
U1 1
U2 42
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2020
VL 29
IS 7
BP 408
EP 418
DI 10.12968/jowc.2020.29.7.408
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA MN3VX
UT WOS:000550773300006
PM 32654604
DA 2026-07-24
ER
PT J
AU Cetinkaya, OA
   Celik, SU
   Boztug, CY
   Uncu, H
AF Cetinkaya, Omer Arda
   Celik, Suleyman Utku
   Boztug, Can Yahya
   Uncu, Hakan
TI Treatment of hard to heal leg ulcers with hyaluronic acid, sodium
   alginate and negative pressure wound therapy
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hyaluronic acid; leg ulcer; negative pressure wound therapy; sodium
   alginate; wound
ID COMBINATION
AB Objective: Hard-to-heal lower extremity ulcer is a common healthcare problem and can lead to a poor quality of life (QoL). Despite the advances in wound care, conventional therapies, such as necrotic tissue debridement, cleansing, treatment of infection and local treatment with dressing application are still considered the standard of care in patients with hard-to-heal leg ulcers. However, managing hard-to-heal ulcers that do not respond well to these methods has led to new treatment strategies. In this study, the effects of hyaluronic acid (HA) and sodium alginate (SA), combined with negative pressure wound therapy (NPWT), in patients with hard-to-heal leg ulcers are evaluated.
   Method: Patients with hard-to-heal lower extremity ulcers were treated with HA-SA combined with NPWT (HA-SA-NWPT, n=11), or conventional therapy (n=14), between June 2014 and September 2015. Demographics, comorbidities, time to complete healing and change in wound area were recorded and compared.
   Results: A total of 25 patients took part. Complete healing was achieved in 63.6% (n=7) of the patients in the HA SA with NPWT group, compared with 14.3% (n=2) of the patients in the conventional therapy group (p=0.017). The mean decrease in wound size was significantly higher in the HA-SA-NPWT group than in the conventional therapy group (73.8% versus 34.8%, respectively, p=0.029). Despite a shorter healing period in the HA-SA-NPWT group than in the conventional group, no statistically significant difference was found between groups for time to complete healing (37 days versus 55 days, respectively).
   Conclusion: These results demonstrate that the combination of HA-SA-NPWT is a promising treatment for decreasing the healing time and increasing the success rate by their synergistic effect on wound healing in hard-to-heal lower extremity ulcers. However, further studies with a larger number of patients are needed to confirm the results.
C1 [Cetinkaya, Omer Arda; Boztug, Can Yahya; Uncu, Hakan] Ankara Univ, Dept Surg, Div Vasc Surg, Sch Med, Ankara, Turkey.
   [Celik, Suleyman Utku] Gulhane Training & Res Hosp, Clin Gen Surg, Ankara, Turkey.
C3 Ankara University; Gulhane Training & Research Hospital
RP Cetinkaya, OA (通讯作者)，Ankara Univ, Dept Surg, Div Vasc Surg, Sch Med, Ankara, Turkey.
EM omerardacetinkaya@yahoo.com
RI Celik, Suleyman Utku/A-4722-2018; /AAI-9984-2020; Boztug, Can
   yahya/HTM-1243-2023
OI Celik, Suleyman Utku/0000-0002-1570-6327; Boztug, Can
   yahya/0000-0001-9980-0873
CR [Anonymous], 2014, REV, DOI DOI 10.1111/OBR.12215
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   Xie X, 2010, J WOUND CARE, V19, P488
NR 18
TC 4
Z9 4
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2020
VL 29
IS 7
BP 419
EP 423
DI 10.12968/jowc.2020.29.7.419
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA MN3VX
UT WOS:000550773300007
PM 32654603
DA 2026-07-24
ER
PT J
AU Hu, XX
   Ni, YB
   Lian, WS
   Kang, L
   Jiang, JX
   Li, MQ
AF Hu, Xiaoxiao
   Ni, Yebin
   Lian, Weishuai
   Kang, Li
   Jiang, Jinxia
   Li, Maoquan
TI Combination of negative pressure wound therapy using vacuum-assisted
   closure and ozone water flushing for treatment of diabetic foot ulcers
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Negative pressure wound therapy; Vacuum-assisted closure; Ozone water
   flushing; Diabetic foot ulcers
ID MANAGEMENT; EFFICACY
AB Objective To investigate the efficacy of negative pressure wound therapy (NPWT) using vacuum-assisted closure (VAC) and ozone water flushing for the treatment of diabetic foot ulcers. Methods The present study included 136 consecutive diabetic foot ulcers (DFUs) patients who went to our hospital during April 2016 to August 2017. The patients were randomly divided into two groups: the combined group in which patients received both VAC and ozone water flushing, and the VAC group in which patients received only VAC. Clinical outcomes were recorded and the change of the wound surface area was calculated. The pain condition was evaluated using the visual analogue scale (VAS) scores. Results The duration of the treatment was significantly shorter and the dressing change times and peak VAS scores were both dramatically lower in the combined group than the VAC group. The reduction of the wound surface area was significantly larger after 1-week, 2-week, and 3-week treatment in the combined group; however, no significant difference was found after 1-month treatment. The bacterial clearance rate was significantly higher after 2-week treatment in the combined group compared with the VAC group; however, no significant difference was found after the whole treatment. No significant difference was observed in the recurrence and amputation rates. Conclusion The combination use could enhance the recovery of DFUs, shorten the treatment duration, and reduce the pain during treatment.
C1 [Hu, Xiaoxiao; Ni, Yebin; Lian, Weishuai; Kang, Li; Li, Maoquan] Tongji Univ, Sch Med, Peoples Hosp 10, Intervent Vasc Surg, Shanghai 200072, Peoples R China.
   [Jiang, Jinxia] Tongji Univ, Sch Med, Peoples Hosp 10, Emergency Dept, Shanghai 200072, Peoples R China.
C3 Tongji University; Tongji University
RP Li, MQ (通讯作者)，Tongji Univ, Sch Med, Peoples Hosp 10, Intervent Vasc Surg, Shanghai 200072, Peoples R China.; Jiang, JX (通讯作者)，Tongji Univ, Sch Med, Peoples Hosp 10, Emergency Dept, Shanghai 200072, Peoples R China.
EM xiaoxiao.emily.hu@foxmail.com; niyebin_115@sina.com;
   lianweishuai@126.com; kangli_yj@126.com; jiangjinxia_1@21cn.com;
   dio6er@163.com
RI Hu, Xiaoxiao/HPG-3615-2023; Kang, Liping/NTQ-3522-2025
CR Ali Enas Mohamed, 2013, Diabetologia Croatica, V42, P3
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NR 28
TC 8
Z9 11
U1 2
U2 36
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD APR
PY 2020
VL 40
IS 2
BP 290
EP 295
DI 10.1007/s13410-019-00769-4
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MO4RA
UT WOS:000551514100021
DA 2026-07-24
ER
PT J
AU Diehm, YF
   Loew, J
   Will, PA
   Fischer, S
   Hundeshagen, G
   Ziegler, B
   Gazyakan, E
   Kneser, U
   Hirche, C
AF Diehm, Yannick F.
   Loew, Julia
   Will, Patrick A.
   Fischer, Sebastian
   Hundeshagen, Gabriel
   Ziegler, Benjamin
   Gazyakan, Emre
   Kneser, Ulrich
   Hirche, Christoph
TI Negative pressure wound therapy with instillation and dwell time
   (NPWTi-d) with V. A. C.VeraFloin traumatic, surgical, and chronic
   wounds-A helpful tool for decontamination and to prepare successful
   reconstruction
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bacterial colonisation; dwell time; NPWTi-d; wounds; instillation;
   negative pressure wound therapy; reconstruction
ID SALINE INSTILLATION
AB For nearly two decades, Negative Pressure Wound Therapy (NPWT) has been used for temporary wound coverage as well as wound bed preparation. The addition of instillation and dwell time as an adjunct to NPWT (NPWTi-d) enables wound bed cleaning and improved wound bed granulation. Thirty patients with different types of colonised wounds (traumatic, surgical, and chronic) were treated with NPWTi-d using saline for instillation. Patient data, microbiological data and wound characteristics were collected and analysed. Endpoints were bacterial decontamination (count and type), effect on wound bed granulation, and successful reconstruction. Additionally, subgroup analyses for traumatic, surgical, and chronic wounds as well as patients pretreated with conventional NPWT or isolated gram-positive or negative germs were performed. NPWTi-d was applied on average for 13 days with a total hospitalisation time of 51 days. After NPWTi-d, decontaminated wounds were detected in 23% of cases. The number of different bacteria as well as bacterial count could be significantly reduced from 2.38 to 1.16 and 3.9 to 1.3, respectively. This was similar for all subgroups except surgical wounds, in which NPWTi-d did not lead to a significant reduction of the bacterial count. NPWTi-d resulted in a significant stimulation of granulation tissue. Successful reconstruction was achieved in 90% of cases. NPWTi-d enabled wound pre-conditioning by powerfully reducing or decontaminating the bacterial load and spectrum in most of the wounds. The wound bed integrity was re-established to prepare successful reconstruction.
C1 [Diehm, Yannick F.; Loew, Julia; Will, Patrick A.; Fischer, Sebastian; Hundeshagen, Gabriel; Ziegler, Benjamin; Gazyakan, Emre; Kneser, Ulrich; Hirche, Christoph] BG Trauma Ctr Ludwigshafen, Burn Ctr, Dept Hand Plast & Reconstruct Surg, Microsurg, Ludwigshafen, Germany.
   [Diehm, Yannick F.; Loew, Julia; Will, Patrick A.; Fischer, Sebastian; Hundeshagen, Gabriel; Ziegler, Benjamin; Gazyakan, Emre; Kneser, Ulrich; Hirche, Christoph] Heidelberg Univ, Hand & Plast Surg, Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg
RP Hirche, C (通讯作者)，Heidelberg Univ, Dept Hand Plast & Reconstruct Surg, Microsurg, Burn Ctr,BG Trauma Ctr, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
EM christoph.hirche@bgu-ludwigshafen.de
RI Will, Patrick/KHX-8668-2024; Gazyakan, Emre/HLW-5585-2023
CR Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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NR 16
TC 24
Z9 28
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2020
VL 17
IS 6
BP 1740
EP 1749
DI 10.1111/iwj.13462
EA JUL 2020
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA PE3BU
UT WOS:000552421100001
PM 32716140
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Marangi, GF
   Segreto, F
   Coppola, MM
   Arcari, L
   Gratteri, M
   Persichetti, P
AF Marangi, Giovanni F.
   Segreto, Francesco
   Coppola, Marco Morelli
   Arcari, Lucrezia
   Gratteri, Marco
   Persichetti, Paolo
TI Management of chronic seromas: A novel surgical approach with the use of
   vacuum assisted clousure therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE capsulectomy; chronic seroma; Morel-Lavellee; postoperative
   complication; vacuum-assisted clousure
ID MOREL-LAVALLEE LESION; PREVENTION
AB Postoperative seroma is a common complication of many surgical procedures in which anatomical dead space has been created. A particular case of lesion in which seroma occurs is the Morel-Lavallee lesion (MLL), which is an uncommon closed soft-tissue degloving injury that develops after high-energy trauma or crush injury where shearing forces separate the subcutaneous tissue from the underlying fascia. The diagnostic evaluation begins with an adequate history and physical examination, followed by instrumental research with ultrasonography, computed tomography, and magnetic resonance imaging. Postoperative seromas and MLLs share a similar pathology and natural evolution as both injuries, once chronic, develop a pseudobursa; thus, the authors think that the same treatment algorithm may be suitable for both the lesions. Several strategies for the treatment of post-surgical and post-traumatic seromas have been described in the literature, ranging from conservative measures for acute and small injuries to surgical management and sclerotherapy for chronic and large ones. Despite some seromas resolving with conventional management, lesion recurrence is a matter of concern. The authors present their experience in the treatment of both post-surgical and post-traumatic chronic seromas not responsive to conservative treatments by surgical drainage of the seroma, capsulectomy, and application of vacuum-assisted closure therapy to allow granulation tissue formation, dead spaces obliteration, and wound healing. Primary wound closure with closed suction drain placement and an elastic compression bandaging are finally performed. From 2014 to 2019, a total of 15 patients (9 females and 6 males) were treated for recurrent chronic seromas with the proposed surgical approach. Five cases were MLLs, while 10 cases were postoperative seromas. The patients were between 33 and 79 years old, and they were followed up at 4 weeks and 3 and 6 months after surgery. All 15 patients with chronic seromas not responsive to conservative treatment showed a complete resolution of the lesions with the proposed treatment approach with no evidence of lesion recurrence, proving its effectiveness.
C1 [Marangi, Giovanni F.; Segreto, Francesco; Coppola, Marco Morelli; Arcari, Lucrezia; Gratteri, Marco; Persichetti, Paolo] Campus Biomed Rome Univ, Div Plast Surg, Via A del Portillo 200, I-00100 Rome, Italy.
RP Marangi, GF (通讯作者)，Campus Biomed Rome Univ, Div Plast Surg, Via A del Portillo 200, I-00100 Rome, Italy.
EM g.marangi@unicampus.it
RI Marangi, Giovanni Francesco/AAW-4723-2020; Morelli Coppola,
   Marco/GSE-2476-2022; Gratteri, Marco/KGM-5481-2024
OI Marangi, Giovanni Francesco/0000-0002-7179-3533; Morelli Coppola,
   Marco/0000-0002-8910-6586; Segreto, Francesco/0000-0002-1573-1098;
   Gratteri, Marco/0000-0001-7375-1524
CR Abdalla S, 2018, SURG TECHNOL INT, V33
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NR 21
TC 14
Z9 18
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1153
EP 1158
DI 10.1111/iwj.13447
EA JUL 2020
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000552426300001
PM 32716145
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Chan, BCF
   Campbell, KE
AF Chan, Brian C-F
   Campbell, Karen E.
TI An economic evaluation examining the cost-effectiveness of continuous
   diffusion of oxygen therapy for individuals with diabetic foot ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE cost-benefit analysis; diabetic foot
ID PRESSURE WOUND THERAPY; HYPERBARIC-OXYGEN; TOPICAL OXYGEN; DOUBLE-BLIND;
   POPULATION; MORTALITY; ASSOCIATION; MULTICENTER; MANAGEMENT; AMPUTATION
AB Continuous delivery of oxygen therapy has been observed to improve healing for individuals with an advanced diabetic foot ulcer (DFU). However, this intervention requires the purchasing of an oxygen delivery device and moist dressings. It is unknown whether this upfront financial investment represents good value for money. Thus the aim of this project is to evaluate the cost-effectiveness of treating advanced DFU using continuous delivery of oxygen compared with negative pressure wound therapy from the perspective of the public health care payer in Ontario, Canada. A microsimulation model was constructed with inputs from peer-reviewed journal publications and publicly available reports. The 5-year costs and quality-adjusted life-years were compared between treatment and comparator. Sensitivity analyses were conducted to evaluate the robustness of results. The model predicted that continuous delivery of oxygen would cost $4800 less compared with negative pressure wound therapy and increased quality-adjusted life years by 0.025. Lower cost and improved outcomes were observed in most scenario analyses. The results of this economic evaluation suggest that CDO therapy may reduce health care economic burden with a modest increase in quality of life outcomes. Health care decision-makers should consider the inclusion of CDO for the treatment of DFU.
C1 [Chan, Brian C-F] Univ Hlth Network, KITE Toronto Rehabil Inst, 520 Sutherland Dr,Room 206, Toronto, ON M4G 3V9, Canada.
   [Chan, Brian C-F] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada.
   [Campbell, Karen E.] Western Univ, Fac Hlth Sci, Sch Phys Therapy, London, ON, Canada.
C3 University of Toronto; University Health Network Toronto; Toronto
   Rehabilitation Institute; University of Toronto; Western University
   (University of Western Ontario)
RP Chan, BCF (通讯作者)，Univ Hlth Network, KITE Toronto Rehabil Inst, 520 Sutherland Dr,Room 206, Toronto, ON M4G 3V9, Canada.
EM brian.chan@uhn.ca
RI Chan, Brian/AAF-3874-2021
OI Chan, Brian/0000-0001-5037-0446
FU EO2 Concepts Incorporated
FX EO2 Concepts Incorporated
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NR 54
TC 14
Z9 18
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2020
VL 17
IS 6
BP 1791
EP 1808
DI 10.1111/iwj.13468
EA JUL 2020
PG 18
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA PE3BU
UT WOS:000552620400001
PM 33189100
OA Green Accepted, hybrid
DA 2026-07-24
ER
PT J
AU Türköz, R
   Dogan, A
   Türkekul, Y
   Özker, E
AF Turkoz, Riza
   Dogan, Abdullah
   Turkekul, Yasemin
   Ozker, Emre
TI Successful treatment of thoracic aortic graft infection by omental flap
   following vacuum-assisted closure therapy
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
DE aortic graft infection; omental transposition; vacuum-assisted closure
AB Background Postoperative thoracic aortic graft infection (TAGI) is a serious and potentially fatal complication. The classical approach is to replace the infected graft. However, this approach has a high mortality rate. Alternatively, treatment of TAGI without graft replacement can be performed Method Herein, we present a 72-year-old case with mediastinitis and graft infection after type A aortic dissection operation and successful treatment using omental flap coverage following vacuum-assisted wound closure therapy without graft replacement. Conclusion The patient had an uneventful postoperative course and remains infection-free to date.
C1 [Dogan, Abdullah] Acibadem Bakirkoy Hosp, Dept Cardiovasc Surg, Istanbul, Turkey.
   [Turkekul, Yasemin] Univ Hlth Sci, Istanbul Training & Res Hosp, Dept Cardiovasc Surg, Istanbul, Turkey.
   [Ozker, Emre] Altunizade Acibadem Hosp, Dept Wound Care, Istanbul, Turkey.
C3 Acibadem Hospitals Group; Acibadem Hastaneleri; University of Health
   Sciences Turkey; Istanbul Training & Research Hospital
RP Dogan, A (通讯作者)，Halit Ziya Usakligil Cad 1 Bakirkoy, TR-34140 Istanbul, Turkey.
EM doganabdullah65@gmail.com
RI ; Doğan, Abdullah/OEN-7631-2025
OI Turkoz, Riza/0000-0002-6617-2601; Doğan, Abdullah/0000-0002-7446-2502
CR Bianco V, 2018, J CARDIAC SURG, V33, P658, DOI 10.1111/jocs.13792
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   Umminger J, 2016, EUR J CARDIO-THORAC, V50, P660, DOI 10.1093/ejcts/ezw150
NR 8
TC 1
Z9 1
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD OCT
PY 2020
VL 35
IS 10
BP 2857
EP 2859
DI 10.1111/jocs.14884
EA JUL 2020
PG 3
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA NT5YX
UT WOS:000552622100001
PM 32720391
DA 2026-07-24
ER
PT J
AU Kleinhans, M
   Stoffels, I
   Dissemond, J
AF Kleinhans, Monika
   Stoffels, Ingo
   Dissemond, Joachim
TI Long-term healing of a therapy-refractory venous leg ulcer after crural
   fasciectomy and split skin graft transplantation
SO HAUTARZT
LA German
DT Article
DE Chronic wounds; Shave therapy; Crural fasciectomy; Wound bed
   preparation; Mesh graft technique
ID SHAVE-THERAPY; INSUFFICIENCY; FASCIOTOMY; ETIOLOGY
AB A 59-year-old obese woman had been suffering from a painful, chronic leg ulcer since 1986. We diagnosed a venous leg ulcer due to functional chronic venous insufficiency in the context of obesity per magna (dependency syndrome) and arthrogenic congestion syndrome due to immobility. Although a high ligation and stripping of the great saphenous vein and several so-called shave therapies with split skin transplantation after appropriate wound bed preparation had been previously performed, the wound persisted. In 2012, the patient wanted to amputate her leg because the course of wound healing was so refractory to therapy and she suffered from severe pain. As an alternative to amputation, we performed a crural fascietomy and, after a wound bed preparation with two cycles of negative pressure wound therapy, we covered the defect with a split skin graft using the mesh graft technique. The surgery could be performed without complications and the skin healed completely. At the current presentation 7 years after the intervention, complete healing of the previously therapy-refractory venous leg ulcer was shown despite the persistent obesity per magna and immobility. This case report shows that a crural fasciectomy should be considered, especially in the case of otherwise therapy-refractory courses of venous leg ulcers.
C1 [Kleinhans, Monika; Stoffels, Ingo; Dissemond, Joachim] Univ Klinikum Essen, Klin & Poliklin Dermatol Venerol & Allergol, Hufelandstr 55, D-45122 Essen, Germany.
C3 University of Duisburg Essen
RP Dissemond, J (通讯作者)，Univ Klinikum Essen, Klin & Poliklin Dermatol Venerol & Allergol, Hufelandstr 55, D-45122 Essen, Germany.
EM joachim.dissemond@uk-essen.de
RI Dissemond, Joachim/AFG-0691-2022
FU Projekt DEAL
FX Open Access funding provided by Projekt DEAL.
CR Garzon K, 2010, VASOMED, V22, P2018
   Göstl K, 2009, PHLEBOLOGIE, V38, P108
   Grattenthaler Christiane, 2007, J Dtsch Dermatol Ges, V5, P1144, DOI 10.1111/j.1610-0387.2007.06599.x
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   Schmeller W, 1996, HAUTARZT, V47, P676, DOI 10.1007/s001050050488
NR 10
TC 3
Z9 4
U1 1
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0017-8470
EI 1432-1173
J9 HAUTARZT
JI Hautarzt
PD FEB
PY 2021
VL 72
IS 2
SI SI
BP 157
EP 162
DI 10.1007/s00105-020-04659-3
EA JUL 2020
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QA2FG
UT WOS:000552917700003
PM 32720166
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Lin, KC
   Li, YS
   Tarng, YW
AF Lin, Kai Cheng
   Li, Yi-Syuan
   Tarng, Yih-Wen
TI Safety and Efficacy of Prophylactic Closed Incision Negative Pressure
   Therapy after Acute Fracture Surgery
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE High energy trauma; Orthopeadic trauma; Closed incision; Negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; COMPARTMENT SYNDROME; SURGICAL
   INCISIONS; MANAGEMENT
AB Introduction: Soft tissue swelling after acute fracture surgery is a challenge which may increase wound dehiscence, delay early range of motion, and increase infection rate postoperatively. This study investigates closed incision negative pressure therapy (ciNPT) using wide-range cover over the incision site and the peripheral swelling trauma zone to promote early active motion and to mitigate joint stiffness, bulla formation, and tendon adhesion.
   Methods: Twenty-nine patients were enrolled between January 2018 and December 2018. Patients with high-energy soft tissue trauma and comminuted fractures over distal end of limbs (hand and foot; wrist and ankle) or muscle scarcity areas (tibial shaft or patella) were included. ciNPT was applied over closed incisions in the operating room and subatmospheric pressure (-125 mmHg) initiated continuously for 5 similar to 7 days.
   Results: In hand and foot patients (n=8), active motion over all fingers or toes occurred after postoperative Day 2. Mild swelling without any bullous formation was observed over the dorsal aspect of hand. In wrist and ankle patients (n=16), flexion angle over the finger joints over 90 degrees was observed after 5 days post-surgery. For patients with tibial shaft comminuted fractures with impending compartment syndrome, early active motion of knee and ankle joint was observed as soft tissue swelling and distension pain had subsided after surgery.
   Conclusion: The prophylactic ciNPT use in the trauma area after surgery reduced postoperative distension pain and improved early range of motion of the tendon and joint in these patients. (C) 2020 The Author(s). Published by Elsevier Ltd.
C1 [Lin, Kai Cheng; Li, Yi-Syuan; Tarng, Yih-Wen] Kaohsiung Vet Gen Hosp, Dept Orthopaed, 386 Da Chung 1st Rd, Kaohsiung 813, Taiwan.
   [Tarng, Yih-Wen] Natl Def Med Ctr, Dept Orthopaed, 161,Sect 6,Minquan E Rd, Taipei 114, Taiwan.
C3 Kaohsiung Veterans General Hospital; National Defense Medical University
RP Tarng, YW (通讯作者)，Kaohsiung Vet Gen Hosp, Dept Orthopaed, 386 Da Chung 1st Rd, Kaohsiung 813, Taiwan.
EM qm1047@ms35.hinet.net
OI Li, Yi-Syuan/0000-0002-4936-3123
FU KCI
FX KCI provided funding for this study.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Gabriel A, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001880
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NR 23
TC 4
Z9 5
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD AUG
PY 2020
VL 51
IS 8
BP 1805
EP 1811
DI 10.1016/j.injury.2020.05.032
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA MR8WK
UT WOS:000553870800017
PM 32507454
OA hybrid
DA 2026-07-24
ER
PT J
AU Feng, B
   Li, Z
   Feng, C
   Zeng, A
   Gao, P
   Liu, Y
   Weng, XS
AF Feng, Bin
   Li, Zeng
   Feng, Cheng
   Zeng, Ang
   Gao, Peng
   Liu, Yong
   Weng, Xisheng
TI Early wound complications after orthopaedic surgery for haemophilia:
   What can we do more
SO HAEMOPHILIA
LA English
DT Article
DE early wound complication; haemophilia; risk factors; surgery; vacuum
   sealing drainage
ID EPIDERMAL-GROWTH-FACTOR; TOTAL KNEE REPLACEMENT; SURGICAL-TREATMENT;
   MANAGEMENT; ARTHROPLASTY; ARTHROPATHY; DRAINAGE; RISK
AB Background The characteristics of the haemophilia may endanger the patient with haemophilia (PWH) to higher ratio of wound complication, even lead to the refractory wound problem. The early wound complication in PWH has not been well studied in literature. Methods Between the period from 2002 to 2018, 250 patients underwent 323 elective orthopaedic surgical procedures for the treatment of haemophilic musculoskeletal disorders. The medical records were retrospectively reviewed. The patients were evaluated for postoperative wound complications within 30 days. Risk factors related to wound complications were further analysed. The patients underwent vacuum sealing drainage (VSD) for refractory wound healing problem were further analysed. Results Twenty-four patients of 250 patients experienced early wound complication within postoperative 30 days. The incidence of wound complication in the patients without preoperative infection was 6.5%. Positive inhibitor and surgery for pseudotumour were associated with higher rate of wound complication after logistic regression, with the odds ratios (OR) of 5.7 (95% CI, 1.08 to 30.3) and 4.9 (95% CI, 1.3 to 18.5), respectively. Eight patients underwent VSD treatment for refractory wound healing problem and recovered uneventfully. The total VSD treatment cycle was 2.25 (from 2 to 4). The average factor consumption was 26.1 IU kg(-1) d(-1). The patients complicated with infection had higher, but not statistically significantly, treatment duration, factor consumption and peri-VSD total blood loss than the patients without infection. Conclusions PWH had an incidence of 6.5% of early wound healing problem after elective orthopaedic surgery for musculoskeletal disorder in the present study. The presence of positive inhibitor and surgical procedure for haemophiliac pseudotumour are associated with higher incidence of wound healing problem. The VSD is an effective alternative for the treatment of refractory wound healing problem for PWH, especially for the patients complicated with infection.
C1 [Feng, Bin; Li, Zeng; Gao, Peng; Liu, Yong; Weng, Xisheng] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, Beijing 100730, Peoples R China.
   [Li, Zeng] South China Univ Technol, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Ctr Orthoped Surg,Sch Med,Div Joint Osteopathy &, Guangzhou, Peoples R China.
   [Feng, Cheng; Zeng, Ang] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Plast Surg, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Southern Medical University - China; South China University of
   Technology; Guangdong Academy of Medical Sciences & Guangdong General
   Hospital; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Peking Union Medical College Hospital; Peking Union Medical
   College
RP Weng, XS (通讯作者)，Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, Beijing 100730, Peoples R China.
EM doctorwxs@163.com
RI /AAT-4908-2020; 冯, 宾/IAR-4784-2023
FU National Natural Science Foundation in China [81871740]
FX This study was supported by a grant from the National Natural Science
   Foundation in China (No. 81871740).
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NR 27
TC 6
Z9 6
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-8216
EI 1365-2516
J9 HAEMOPHILIA
JI Haemophilia
PD SEP
PY 2020
VL 26
IS 5
BP 882
EP 890
DI 10.1111/hae.14113
EA AUG 2020
PG 9
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA NU0EM
UT WOS:000554335900001
PM 32741019
DA 2026-07-24
ER
PT J
AU Jin, SY
   Chen, M
   Wang, FY
   Wang, F
AF Jin, Shi-Ying
   Chen, Mei
   Wang, Feng-Yuan
   Wang, Fei
TI Applying Intravenous Immunoglobulin and Negative-Pressure Wound Therapy
   to Treat Refractory Pyoderma Gangrenosum: A Case Report
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE pyoderma gangrenosum; neutrophilic dermatosis; negative-pressure wound
   therapy; intravenous immunoglobulin; ulcer
AB Pyoderma gangrenosum (PG) is a rare chronic neutrophilic dermatosis that causes undermining ulcers. Unfortunately, standardization of PG treatment remains a challenge. In this article, we describe a case in which a 69-year-old man presented with a painful ulcer on the right lower leg. The diagnosis of PG was made after excluding other diseases. He had a history of PG on his left lower leg 2 years earlier and was cured by the treatment of systemic corticosteroids and cyclosporin A for 43 days. However, such a treatment was not effective this time. Hence, we applied intravenous immunoglobulin and negative-pressure wound therapy, and the patient was cured. Altogether, this case supports the use of intravenous immunoglobulin as an effective adjuvant for refractory PG, and indicates negative-pressure wound therapy as a treatment option to advance ulcer healing under adequate immunosuppression.
C1 [Jin, Shi-Ying; Chen, Mei; Wang, Feng-Yuan; Wang, Fei] Southeast Univ, Zhongda Hosp, Nanjing, Jiangsu, Peoples R China.
C3 Southeast University - China
RP Wang, F (通讯作者)，87 Dingjiaqiao Rd, Nanjing 210009, Jiangsu, Peoples R China.
EM ffwangfei@163.com
OI Jin, Shiying/0000-0003-1278-0123
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   Ormerod AD, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.h2958
   Pichler M, 2017, J EUR ACAD DERMATOL, V31, pE61, DOI 10.1111/jdv.13727
   Shaath TS, 2019, J DRUGS DERMATOL, V18, P307
   Song H, 2018, BRIT J DERMATOL, V178, P363, DOI 10.1111/bjd.15850
   Xu A, 2020, J AM ACAD DERMATOL, V83, P425, DOI 10.1016/j.jaad.2019.08.001
NR 13
TC 6
Z9 8
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD JUN
PY 2021
VL 20
IS 2
BP 158
EP 161
AR 1534734620940459
DI 10.1177/1534734620940459
EA JUL 2020
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SO1ZP
UT WOS:000554385400001
PM 32734793
DA 2026-07-24
ER
PT J
AU Ge, J
   Kong, KY
   Cheng, XQ
   Li, P
   Hu, XX
   Yang, HL
   Shen, MJ
AF Ge, Jun
   Kong, Ke-Yu
   Cheng, Xiao-Qiang
   Li, Peng
   Hu, Xing-Xing
   Yang, Hui-Lin
   Shen, Min-Jie
TI Missed diagnosis of femoral deep artery rupture after femoral shaft
   fracture: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Femoral shaft fracture; Femoral deep artery branch rupture; Perforating
   artery rupture; Thigh compartment syndrome; Rhabdomyolysis; External
   fixation; Case report
ID ACUTE COMPARTMENT SYNDROME; INJURY; PSEUDOANEURYSM; RHABDOMYOLYSIS;
   MANAGEMENT
AB BACKGROUND
   Vascular injury is a rare complication of femoral shaft fractures, and rupture of the deep femoral artery is more difficult to diagnose because of its anatomical location and symptoms. Despite its low incidence, deep femoral artery rupture can lead to life-threatening outcomes, such as compartment syndrome, making early identification and diagnosis critical.
   CASE SUMMARY
   A 45-year-old male patient was admitted to our hospital due to right lower limb trauma in a car accident, with complaints of severe pain and swelling on his right thigh. X-ray demonstrated a right femoral shaft fracture. During preparation for emergency surgery, his blood pressure and blood oxygen saturation dropped, and sensorimotor function was lost. Computed tomography angiography was performed immediately to confirm the diagnosis of rupture of the deep femoral artery and compartment syndrome, so fasciotomy and vacuum-assisted closure were performed. Rhabdomyolysis took place after the operation and the patient was treated with appropriate electrolyte correction and diuretic therapy. Twenty days after the fasciotomy, treatment with the Hoffman Type II External Fixation System was planned, but it was unable to be immobilized internally based on a new esophageal cancer diagnosis. We kept the external fixation for 1 year, and 3 years of follow-up showed improvement of the patient's overall conditions and muscle strength.
   CONCLUSION
   For patients with thigh swelling, pain, anemia, and unstable vital signs, anterior femoral artery injury should be highly suspected. Once diagnosed, surgical treatment should be performed immediately and complications of artery rupture must be suspected and addressed in time.
C1 [Ge, Jun; Kong, Ke-Yu; Cheng, Xiao-Qiang; Li, Peng; Hu, Xing-Xing; Yang, Hui-Lin; Shen, Min-Jie] Soochow Univ, Affiliated Hosp 1, Dept Orthopaed Surg, 188 Shizi St, Suzhou 215006, Jiangsu, Peoples R China.
C3 Soochow University - China
RP Shen, MJ (通讯作者)，Soochow Univ, Affiliated Hosp 1, Dept Orthopaed Surg, 188 Shizi St, Suzhou 215006, Jiangsu, Peoples R China.
EM shenminjie@suda.edu.cn
RI Hu, Xingxing/OAJ-6364-2025; Kong, Keyu/MFH-1720-2025
OI Kong, Keyu/0000-0002-5839-6074; Cheng, Xiaoqiang/0000-0002-6853-9083
CR BARR H, 1987, J CARDIOVASC SURG, V28, P193
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NR 30
TC 4
Z9 6
U1 0
U2 4
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD JUL 6
PY 2020
VL 8
IS 13
BP 2862
EP 2869
DI 10.12998/wjcc.v8.i13.2862
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MT3RI
UT WOS:000554885100018
PM 32742996
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kapusta, P
   Konieczny, PS
   Hohendorff, J
   Borys, S
   Toton-Zuranska, J
   Kiec-Wilk, BM
   Wolkow, PP
   Malecki, MT
AF Kapusta, Przemyslaw
   Konieczny, Pawel S.
   Hohendorff, Jerzy
   Borys, Sebastian
   Toton-Zuranska, Justyna
   Kiec-Wilk, Beata M.
   Wolkow, Pawel P.
   Malecki, Maciej T.
TI Negative pressure wound therapy affects circulating plasma microRNAs in
   patients with diabetic foot ulceration
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Diabetic foot syndrome; Diabetic foot ulceration; Negative-Pressure
   Wound Therapy (NPWT); Type 2 Diabetes (T2DM); Plasma microRNA-seq
ID DIFFERENTIAL EXPRESSION ANALYSIS; MANAGEMENT; DIAGNOSIS; MELLITUS; GENES
AB Aims: Negative pressure wound therapy (NPWT) is commonly used in diabetic foot ulceration (DFU). The molecular mechanisms of NPWT action, particularly outside of the wound site, have not been described. We assessed NPWT's effect on circulating miRNA expression levels in type 2 diabetes (T2DM) patients with DFU.
   Methods: We examined 34 T2DM patients treated with either NPWT (n = 24) or standard therapy (ST, n = 10). The group assignment was based on clinical criteria and local practice. Next-generation sequencing-based microRNA expression was determined on the patient's plasma collected before therapy and after 8 days.
   Results: NPWT patients were similar to the ST group in terms of age, BMI, and HbA1c level; however, they differed by mean wound area (12.6 cm(2) vs. 1.1 cm(2) p = 0.0005). First, we analyzed the change of miRNA after NPWT or ST and observed an upregulation of let-7f-2 only in the NPWT group. Then, we analyzed the differential expression between NPWT and ST groups, looking at possible wound size effects. We found 12 differentially expressed miRNAs in pre-treatment comparison, including let-7f-2, while in post-treatment analysis we identified 28 miRNAs. The pathway enrichment analysis suggests that identified miRNAs may be involved in wound healing, particularly through angiogenesis.
   Conclusion: We found initial evidence that NPWT in T2DM patients with DFU affects miRNA expression in plasma. Additionally, some differences in plasma miRNA expression may be related to wound size. (C) 2020 Elsevier B.V. All rights reserved.
C1 [Kapusta, Przemyslaw; Konieczny, Pawel S.; Toton-Zuranska, Justyna; Wolkow, Pawel P.] Jagiellonian Univ, Coll Med, Ctr Med Genom OMICRON, 7 Kopernika St, PL-31034 Krakow, Poland.
   [Hohendorff, Jerzy; Borys, Sebastian; Kiec-Wilk, Beata M.; Malecki, Maciej T.] Jagiellonian Univ, Coll Med, Dept Metab Dis, 15 Kopernika St, PL-31501 Krakow, Poland.
   [Hohendorff, Jerzy; Borys, Sebastian; Kiec-Wilk, Beata M.; Malecki, Maciej T.] Univ Hosp, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Wolkow, PP (通讯作者)，Jagiellonian Univ, Coll Med, Ctr Med Genom OMICRON, 7 Kopernika St, PL-31034 Krakow, Poland.; Malecki, MT (通讯作者)，Jagiellonian Univ, Coll Med, Dept Metab Dis, 15 Kopernika St, PL-31501 Krakow, Poland.
EM pawel.wolkow@uj.edu.pl; pawel.wolkow@uj.edu.pl; maciej.malecki@uj.edu.pl
RI Wolkow, Pawel/AAI-4222-2021; Hohendorff, Jerzy/U-1857-2018; Konieczny,
   Pawel/D-7537-2017; Totoń-Żurańska, Justyna/AAM-9149-2021
OI Hohendorff, Jerzy/0000-0003-1153-8669; Konieczny,
   Pawel/0000-0002-6173-3836; Totoń-Żurańska, Justyna/0000-0001-5970-238X
FU National Science Centre in Poland [2013/11/B/NZ5/03298]
FX YThe study was funded by the National Science Centre in Poland through
   the Opus Grant ''Assessment of molecular mechanisms of negative
   pressurewound therapy in the treatment of neuropathic ulceration in
   diabetic foot syndrome"to MTM (Nr 2013/11/B/NZ5/03298).
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NR 45
TC 12
Z9 14
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD JUL
PY 2020
VL 165
AR 108251
DI 10.1016/j.diabres.2020.108251
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MT4EL
UT WOS:000554922700028
PM 32531327
OA Green Submitted
DA 2026-07-24
ER
PT J
AU De Monti, M
   Cestaro, G
   Bertani, A
   Torre, A
   Fasolini, F
AF De Monti, Marco
   Cestaro, Giovanni
   Bertani, Annalisa
   Torre, Alessandro
   Fasolini, Fabrizio
TI Disposable negative-pressure wound therapy in outpatients: outcome
   comparison between electrically- and mechanically-powered devices
SO MINERVA BIOTECNOLOGICA
LA English
DT Article
DE Negative-pressure wound therapy; Wound healing; Ulcer
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; SYSTEM; ULCERS
AB BACKGROUND: Disposable negative-pressure wound therapy (NPWT) represents a useful tool to treat difficult healing skin defects in all outpatient setting. In this paper, authors performed a retrospective analysis regarding all patients treated with electrical or mechanical portable NPWT devices.
   METHODS: NPWT devices used from November 1st, 2015 to May 1st, 2018 have been considered, for a total of 72 treatments in 53 patients, average age 67 years (median age 73.7 years; IQR 53.8-86.7); all types of ulcers have been treated. The average duration of treatment was 17 days (median duration 14 days; IQR 7-27). We used one model of electrical devices at -125 mmHg (ED125) and two model of mechanical devices at -75 mmHg and -125 mmHg (MD75 and MD125). The type of dressing was identical in the three systems.
   RESULTS: In this series no statistical difference has been observed between mechanical and electrical devices (bivariate descriptive analysis with chi-squared or Fisher's Exact test) in terms of healing, lesion evolution, ability to prepare the wound bed for skin grafts or for the switch to advanced dressings. On the other hand, we have encountered significant difference (P=0.022) for the better ability of devices set at -125 to manage exudates.
   CONCLUSIONS: We believe that the choice of the device should be made by evaluating the amount of secretions, the possibility to obtain a good adhesion of the system and, primarily, the compliance of the patient. Both systems represent a valid support for the treatment of difficult healing wounds.
C1 [De Monti, Marco; Cestaro, Giovanni; Bertani, Annalisa; Torre, Alessandro; Fasolini, Fabrizio] EOC Beata Vergine Reg Hosp, Dept Gen Surg, Via Turconi 23, CH-6850 Mendrisio, Switzerland.
RP De Monti, M (通讯作者)，EOC Beata Vergine Reg Hosp, Dept Gen Surg, Via Turconi 23, CH-6850 Mendrisio, Switzerland.
EM marco.demonti@eoc.ch
RI De Monti, Marco/HJI-5543-2023; Cestaro, Giovanni/AHE-2766-2022
OI De Monti, Marco/0000-0003-0927-3438; Cestaro,
   Giovanni/0000-0002-9091-0731
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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NR 22
TC 0
Z9 0
U1 0
U2 0
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 1120-4826
EI 1827-160X
J9 MINERVA BIOTECNOL
JI Minerva Biotechnol.
PD MAR
PY 2020
VL 32
IS 1
BP 6
EP 12
DI 10.23736/S1120-4826.19.02584-9
PG 7
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA MT6QC
UT WOS:000555096400002
DA 2026-07-24
ER
PT J
AU Fernández, LG
   Matthews, MR
   Benton, C
   Buresch, R
   Sutherland, A
   Tillison, N
   Brooks, J
AF Fernandez, Luis G.
   Matthews, Marc R.
   Benton, Carol
   Buresch, Rebecca
   Sutherland, Angela
   Tillison, Natalie
   Brooks, Jenny
TI Use of a novelsilicone-acrylicdrape with negative pressure wound therapy
   in anatomically challenging wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure wound therapy; periwound skin; product testing; wound
   healing
ID VACUUM-ASSISTED CLOSURE; ULCERS; STATE
AB Negative pressure wound therapy (NPWT) utilises a polyurethane drape with acrylic adhesive over foam dressings to create a seal. In anatomically challenging areas, ancillary products are frequently used. Additionally, health care providers are unable to reposition the drape once placed. A novel hybrid drape consisting of polyurethane film with acrylic adhesive and silicone perforated layer has been developed to allow for repositioning after initial placement and easy removal. This six-patient case series evaluates the use of NPWT with hybrid drape over anatomically challenging wounds. Three males and three females were treated. Dressing changes occurred every 2 to 3 days. Drape application, repositioning, and ability to maintain a seal were evaluated. During application, the drape was repositioned 1 to 2 times without periwound skin irritation in 4/6 wounds. Prior to initial application, ancillary products were applied to help create a seal. However, by the second or third application, ancillary products were no longer used in 4/6 wounds. None of the dressing applications resulted in negative pressure seal leaks. In these patients, health care providers could reposition the hybrid drape after initial placement without periwound skin irritation and successfully create a negative pressure seal without ancillary products in anatomically challenging wound locations.
C1 [Fernandez, Luis G.; Benton, Carol; Buresch, Rebecca; Sutherland, Angela; Tillison, Natalie; Brooks, Jenny] Univ Texas Tyler, Hlth Sci Ctr, Div Trauma Surg Surg Crit Care, Dept Surg, Tyler, TX 75799 USA.
   [Fernandez, Luis G.; Benton, Carol; Buresch, Rebecca; Sutherland, Angela; Tillison, Natalie; Brooks, Jenny] Univ Texas Arlington, Dept Med & Nursing, Arlington, TX 76019 USA.
   [Fernandez, Luis G.; Benton, Carol; Buresch, Rebecca; Sutherland, Angela; Tillison, Natalie; Brooks, Jenny] Univ North Texas, Dept Med Educ Hlth Sci Ctr, Dept Phys Assistant Studies, Ft Worth, TX USA.
   [Matthews, Marc R.] Univ Arizona, Coll Med, Maricopa Med Ctr, Burn Emergency Serv,Resp Care Serv,Arizona Burn C, Phoenix, AZ USA.
C3 University of Texas System; University of Texas-Health Sciences Center
   at Tyler (UTHSCT); University of Texas at Tyler; University of Texas
   System; University of Texas Arlington; University of North Texas System;
   University of North Texas Denton; University of Arizona
RP Fernández, LG (通讯作者)，UT Hlth East Texas Phys Tyler, Trauma Surg, Div Trauma Surg Surg Crit Care, Dept Surg, 1020 E Idel St, Tyler, TX 75701 USA.
EM thebigkahuna115@gmail.com
RI FERNANDEZ, LUIS/O-7657-2019
CR Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Collier Mark, 2019, Br J Nurs, V28, pS26, DOI [10.12968/bjon.2019.28.15.s26, 10.12968/bjon.2019.28.15.S26]
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NR 10
TC 13
Z9 13
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2020
VL 17
IS 6
BP 1829
EP 1834
DI 10.1111/iwj.13471
EA AUG 2020
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA PE3BU
UT WOS:000555410800001
PM 32755012
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Yang, YP
   Yu, LY
   Wang, M
   Mu, Y
   Li, JN
   Shang, FJ
   Wu, XF
   Liu, TJ
   Shi, J
AF Yang, Yong-Ping
   Yu, Ling-Yun
   Wang, Min
   Mu, Yu
   Li, Jian-Nan
   Shang, Feng-Jia
   Wu, Xian-Feng
   Liu, Tong-Jun
   Shi, Jian
TI A new surgical approach of direct perineal wound full-thick closure for
   perineal wound of abdominoperineal resection for rectal carcinoma: A
   prospective cohort trial
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE APR; direct perineal wound full-thick closure; hypoalbuminemia
ID NEGATIVE-PRESSURE THERAPY; SHORT-TERM OUTCOMES; RISK-FACTORS; EXCISION;
   CANCER; RECONSTRUCTION; COMPLICATIONS; EXPERIENCE; RADIOTHERAPY
AB Perineal wound complications after APR have high morbidity in the colorectal surgical department. Although some approaches have been figured out to solve this clinical focus, the outcomes are still not satisfied. Herein, this prospective comparative clinical trial has been designed to evaluate a new surgical procedure of direct perineal wound full-thick closure (DPWC), compared with conventional perineal wound closure (CPWC), with hopes of making wound healing with less complications. In addition, an evaluation of an incision negative wound pressure therapy, as another focus in this field, was also analysed in the DPWC group. A total of 44 participants in our department were recruited from March 2018 to March 2020, divided into two groups randomly, CPWC group and DPWC group. The patients' characteristics, such as age, gender, BMI, smoking, alcohol consumption, comorbidities, CEA level, and high-risk of invasion, were recorded without statistical significance between the CPWC group and DPWC group. After the same standard abdominal phase, these two groups were performed in different perineal phases. And then, operative and postoperative outcomes were analysed with different statistical methods. Data on wound healing time and length of stay in the DPWC group were shorter than those in the CPWC group (P < .05). Furthermore, cases of wound infection within 30 days in the DPWC group were also less than that in the CPWC group (P < .05). However, no difference was found between the incisional negative pressure wound therapy assisted group (NPA group) and non- incisional negative pressure wound therapy assisted group (non-NPA group). During this study, hypoalbuminemia, as an independent high-risk factor, impacted perineal wound healing. (P= .0271) In conclusion, DPWC is a new surgical approach, which can lead to a better outcome than DPWC, and it can be another surgical procedure for clinicians. In addition, hypoalbuminemia should be interfered for avoiding perineal wound complications.
C1 [Yang, Yong-Ping; Wang, Min; Mu, Yu; Li, Jian-Nan; Shang, Feng-Jia; Wu, Xian-Feng; Liu, Tong-Jun; Shi, Jian] Second Hosp Jilin Univ, Dept Gen Surg, Changchun 130041, Peoples R China.
   [Yu, Ling-Yun] First Hosp Jilin Univ, Dept Ear Nose & Throat Surg, Changchun, Peoples R China.
C3 Jilin University; Jilin University
RP Liu, TJ; Shi, J (通讯作者)，Second Hosp Jilin Univ, Dept Gen Surg, Changchun 130041, Peoples R China.
EM tongjunliu@163.com; dr.shi@live.cn
RI Li, Jiannan/ABH-3120-2021
OI Li, Jiannan/0000-0001-9744-7666; Yang, Yongping/0000-0001-6605-1343
CR Althumairi AA, 2016, WORLD J SURG, V40, P1755, DOI 10.1007/s00268-016-3450-0
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NR 36
TC 4
Z9 4
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2020
VL 17
IS 6
BP 1817
EP 1828
DI 10.1111/iwj.13470
EA AUG 2020
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA PE3BU
UT WOS:000555411400001
PM 32755065
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Saramago, P
   Claxton, K
   Welton, NJ
   Soares, M
AF Saramago, Pedro
   Claxton, Karl
   Welton, Nicky J.
   Soares, Marta
TI Bayesian econometric modelling of observational data for
   cost-effectiveness analysis: establishing the value of negative pressure
   wound therapy in the healing of open surgical wounds
SO JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY
LA English
DT Article
DE Economic evaluation; Instrumental variables; Observational data;
   Statistical methods; Surgical wounds
ID INSTRUMENTAL VARIABLE ANALYSIS; HEALTH TECHNOLOGY-ASSESSMENT;
   TASK-FORCE; ELICITATION; DIAGNOSTICS
AB In the absence of evidence from randomized controlled trials on the relative effectiveness of treatments, cost-effectiveness analyses increasingly use observational data instead. Treatment assignment is not, however, randomized, and naive estimates of the treatment effect may be biased. To deal with this bias, one may need to adjust for observed and unobserved confounders. In this work we explore and discuss the challenges of these adjustment strategies within a case-study of negative pressure wound therapy (NPWT) for the treatment of surgical wounds healing by secondary intention. We could not demonstrate that existing uncontrolled confounding affects NPWT effectiveness, and thus there was no evidence that NPWT was cost effective compared with standard dressings for the treatment of surgical wounds healing by secondary intention.
C1 [Saramago, Pedro; Claxton, Karl; Soares, Marta] Univ York, York, N Yorkshire, England.
   [Welton, Nicky J.] Univ Bristol, Bristol, Avon, England.
C3 University of York - UK; University of Bristol
RP Saramago, P (通讯作者)，Univ York, Alcuin Coll, Ctr Hlth Econ, York YO10 5DD, N Yorkshire, England.
EM pedro.saramago@york.ac.uk
RI Soares, Marta Ferreira Oliveira/HJH-3434-2023
OI Soares, Marta Ferreira Oliveira/0000-0003-1579-8513; Welton, Nicky
   J/0000-0003-2198-3205
FU National Institute for Health Research programme grants for applied
   research [RP-PG-0609-10171]; National Institutes of Health Research
   (NIHR) [RP-PG-0609-10171] Funding Source: National Institutes of Health
   Research (NIHR); MRC [MR/P015298/1, MR/K025643/1, MR/R025223/1] Funding
   Source: UKRI; Medical Research Council [MR/K025643/1, MR/P015298/1]
   Funding Source: researchfish; National Institute for Health Research
   [RP-PG-0609-10171] Funding Source: researchfish
FX Funding came from a grant from the National Institute for Health
   Research programme grants for applied research (project
   RP-PG-0609-10171). The funding agreement ensured the authors'
   independence in designing the study, interpreting the data and writing
   and publishing this paper.
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Z9 5
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
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EI 1467-985X
J9 J ROY STAT SOC A
JI J. R. Stat. Soc. Ser. A-Stat. Soc.
PD OCT
PY 2020
VL 183
IS 4
BP 1575
EP 1593
DI 10.1111/rssa.12596
EA AUG 2020
PG 19
WC Social Sciences, Mathematical Methods; Statistics & Probability
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Mathematical Methods In Social Sciences; Mathematics
GA NW6DA
UT WOS:000555800300001
OA Green Submitted, Green Accepted, hybrid
DA 2026-07-24
ER
PT J
AU Helito, CP
   Sobrado, MF
   Giglio, PN
   Bonadio, MB
   Pécora, JR
   Demange, MK
   Gobbi, RG
AF Helito, Camilo Partezani
   Sobrado, Marcel Faraco
   Giglio, Pedro Nogueira
   Bonadio, Marcelo Batista
   Pecora, Jose Ricardo
   Demange, Marco Kawamura
   Gobbi, Riccardo Gomes
TI The use of negative-pressure wound therapy after total knee arthroplasty
   is effective for reducing complications and the need for reintervention
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Negative-pressure wound; Wound dehiscence; Knee arthroplasty; Wound
   complication; Periprosthetic joint infection
ID TOTAL HIP; FRACTURE SURGERY; REVISION HIP; PREVENTION; DRESSINGS;
   INFECTION; RISK
AB Background Wound healing complications are causal factors of prosthesis infection and poor postoperative evolution of patients after total knee arthroplasty (TKA). Negative-pressure wound therapy (NPWT) can be an option to minimize these complications. The aim of this study is to compare the complications of patients undergoing TKA who used a portable NPWT device in the immediate postoperative period with those of a control group. Methods A total of 296 patients were evaluated. Patients were divided into two groups: those who used NPWT for seven days in the postoperative period (Group 1 - prospective evaluated) and those who used conventional dressings (Group 2 - historical control group). Epidemiological data, comorbidities, local parameters related to the surgical wound and complications were evaluated. Results The groups did not differ in regard to sex, age and clinical comorbidities. Overall, 153 (51.7%) patients had at least one risk factor for wound complications. Patients who used NPWT had a lower rate of complications (28.5% vs. 45.7%,p = 0.001) and a lower rate of reintervention in the operating room (2% vs. 8.5%, p = 0.001). Patients in group 1 had a lower incidence of hyperaemia (14.7% vs. 40.2%,p = 0.01), skin necrosis (2.1% vs. 8.5%,p = 0.04) and wound dehiscence (3.1% vs 10.1%,p = 0.03). The use of NPWT was a protective factor for the presence of complications, with an odds ratio of 0.36 (95% CI 0.206-0.629). Conclusion The number of complications related to the wound after TKA is high; however, most of them are minor and have no impact on the treatment and clinical evolution of patients. The use of NPWT decreased the number of surgical wound complications, especially hyperaemia, dehiscence and necrosis, and reduced the need for reintervention.
C1 [Helito, Camilo Partezani; Sobrado, Marcel Faraco; Giglio, Pedro Nogueira; Bonadio, Marcelo Batista; Pecora, Jose Ricardo; Demange, Marco Kawamura; Gobbi, Riccardo Gomes] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Grp Joelho,Inst Ortopedia & Traumatol, Rua Dr Ovidio Pires de Campos 333, BR-05403010 Sao Paulo, SP, Brazil.
   [Helito, Camilo Partezani; Sobrado, Marcel Faraco] Hosp Sirio Libanes, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Hospital Sirio Libanes
RP Sobrado, MF (通讯作者)，Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Grp Joelho,Inst Ortopedia & Traumatol, Rua Dr Ovidio Pires de Campos 333, BR-05403010 Sao Paulo, SP, Brazil.; Sobrado, MF (通讯作者)，Hosp Sirio Libanes, Sao Paulo, Brazil.
EM marcelf@gmail.com
RI Partezani Helito, Camilo/X-3880-2019; Gobbi, Riccardo/C-8131-2012;
   Pécora, José Ricardo/HGD-1086-2022; Demange, Marco/D-2975-2009; Giglio,
   Pedro/A-7488-2017
OI Partezani Helito, Camilo/0000-0003-1139-2524; Gobbi,
   Riccardo/0000-0002-1715-4343; Pécora, José Ricardo/0000-0003-1621-5252;
   Demange, Marco/0000-0003-1999-9478; 
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NR 31
TC 24
Z9 28
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD JUL 25
PY 2020
VL 21
IS 1
AR 490
DI 10.1186/s12891-020-03510-z
PG 8
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA MU9AF
UT WOS:000555957500003
PM 32711504
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hopkins, B
   Eustache, J
   Ganescu, O
   Cipolla, J
   Kaneva, P
   Fried, GM
   Khwaja, K
   Vassiliou, M
   Fata, P
   Lee, L
   Feldman, LS
AF Hopkins, Brent
   Eustache, Jules
   Ganescu, Olivia
   Cipolla, Josie
   Kaneva, Pepa
   Fried, Gerald M.
   Khwaja, Kosar
   Vassiliou, Melina
   Fata, Paola
   Lee, Lawrence
   Feldman, Liane S.
TI S116: Impact of incisional negative pressure wound therapy on surgical
   site infection after complex incisional hernia repair: a retrospective
   matched cohort study
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Incisional hernia; Abdominal wall reconstruction; General surgery; Wound
   complication; Surgical site infection; Negative pressure wound therapy;
   Incisional negative pressure wound therapy
ID ABDOMINAL-WALL RECONSTRUCTION; HIGH-RISK PATIENTS; MANAGEMENT;
   COMPLICATIONS; VALIDATION; LAPAROTOMY; PREVENTION; OUTCOMES; SCORE; COST
AB Introduction Incisional negative pressure wound therapy (iNPWT) may reduce surgical site infections (SSI), which can have devastating consequences after incisional hernia repair. Few comparative studies investigate the effectiveness of this wound management strategy in this population. The objective of this study is to determine the effect of iNPWT on the incidence of SSI after complex incisional hernia repair. Methods All adult patients undergoing open incisional hernia repair at a single center from 2016 to 2019 were reviewed. A commercial iNPWT dressing was used at the discretion of the surgeon. Patients were grouped by type of dressing; iNPWT and standard sterile dressings (SSD). Coarsened exact matching was used to create balanced cohorts for comparison using age, sex, American Society of Anesthesiologists classification, wound classification, and surgical urgency. The primary outcome was the composite incidence of superficial and deep SSI within 30 days. Secondary outcomes included non-infectious surgical site occurrences (SSO), overall complications, length of stay (LOS), emergency department visits, and readmission at 30 days. Results 134 patients underwent complex hernia repair, with 114 patients included after matching (34 iNPWT, 51 SSD). Composite incidence of superficial and deep SSI was 19.3% (11.8% vs. 27.5%,p = 0.107), with significantly lower rates of deep SSI in patients receiving iNPWT (2.9% vs. 17.6%,p = 0.045). After accounting for residual differences between groups, iNPWT was associated with decreased incidence of composite SSI (RR 0.36, 95% CI [0.16, 0.87]). Median LOS was longer in patients with iNPWT (7 vs. 5 days,p = 0.001). There were no differences in SSO, overall complications, readmission, or emergency department visits. Conclusion In patients undergoing incisional hernia repair, the use of iNPWT was associated with a lower incidence of SSI at 30 days. Future studies should focus on cost effectiveness of iNPWT, its impact on long-term hernia recurrences, and the identification of patient selection criteria in this population.
C1 [Hopkins, Brent; Eustache, Jules; Kaneva, Pepa; Fried, Gerald M.; Khwaja, Kosar; Vassiliou, Melina; Fata, Paola; Lee, Lawrence; Feldman, Liane S.] McGill Univ, Hlth Ctr, Steinberg Bernstein Ctr Minimally Invas Surg & In, 1650 Cedar Ave,L9-309, Montreal, PQ H3G 1A4, Canada.
   [Hopkins, Brent; Eustache, Jules; Fried, Gerald M.; Khwaja, Kosar; Vassiliou, Melina; Fata, Paola; Lee, Lawrence; Feldman, Liane S.] McGill Univ, Dept Surg, Hlth Ctr, Montreal, PQ, Canada.
   [Ganescu, Olivia; Cipolla, Josie] McGill Univ, Fac Med, Montreal, PQ, Canada.
C3 McGill University; McGill University; McGill University
RP Lee, L (通讯作者)，McGill Univ, Hlth Ctr, Steinberg Bernstein Ctr Minimally Invas Surg & In, 1650 Cedar Ave,L9-309, Montreal, PQ H3G 1A4, Canada.; Lee, L (通讯作者)，McGill Univ, Dept Surg, Hlth Ctr, Montreal, PQ, Canada.
EM larry.lee@mcgill.ca
RI ; Vassiliou, Melina/HNQ-6575-2023
OI Cipolla, Josie/0009-0009-2365-6567; Fried, Gerald/0000-0001-6434-0555; 
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NR 38
TC 10
Z9 13
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD JUL
PY 2021
VL 35
IS 7
BP 3949
EP 3960
DI 10.1007/s00464-020-07857-1
EA AUG 2020
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SR2RM
UT WOS:000556653600001
PM 32761478
DA 2026-07-24
ER
PT J
AU Xing, D
   Yang, ZX
   Cao, C
   Dong, ZJ
   Wei, JC
   Zheng, XH
   Li, WY
AF Xing, Dong
   Yang, Zhaoxu
   Cao, Can
   Dong, Zhijie
   Wei, Jingchao
   Zheng, Xuehong
   Li, Wenyi
TI A modified negative pressure wound therapy for the treatment of
   refractory wounds A preliminary study
SO MEDICINE
LA English
DT Article
DE modified negative pressure wound therapy; refractory wounds; total cost;
   wound-healing time
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; REPAIR
AB Negative pressure wound therapy (NPWT) is an important therapy for the management of refractory wounds. The aim of this retrospective preliminary study was to introduce a modified NPWT (m-NPWT) and compared the efficacy of it with conventional NPWT (c-NPWT) in the management of refractory wounds. A total of 127 patients with refractory wounds receiving the NPWT from January 2010 to October 2017 in our hospital were retrospectively reviewed. The demographics and clinical data were collected from medical records and compared between m-NPWT group and c-NPWT group. There were 65 patients in c-NPWT group and 62 patients in m-NPWT group. No significant difference was observed between 2 groups in antimicrobial use (P = .51), hospitalization time (P = .24), wound-healing rate (P = .44) or complication rate (P = .59). However, patients in m-NPWT group had shorter wound-healing time (24.82 vs 27.66 days,P < .01), less debridement times (1.23 vs 2.08,P < .01), less total cost (3743.93 vs 6344.33 yuan,P < .01) and higher satisfaction rate (56/62 vs 44/65,P = .02) compared to those in c-NPWT group. The m-NPWT technique was an efficient and safe alternative therapy for refractory wounds.
C1 [Xing, Dong; Yang, Zhaoxu; Cao, Can; Dong, Zhijie; Wei, Jingchao; Zheng, Xuehong; Li, Wenyi] Hebei Gen Hosp, Dept Orthoped, 348 Heping Rd, Shijiazhuang 050000, Hebei, Peoples R China.
RP Li, WY (通讯作者)，Hebei Gen Hosp, Dept Orthoped, 348 Heping Rd, Shijiazhuang 050000, Hebei, Peoples R China.
EM doctor_lwy@163.com
FU Health Commission of Hebei Province [20150592]
FX This work was supported by the Health Commission of Hebei Province
   (No.20150592).
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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NR 28
TC 5
Z9 7
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL 10
PY 2020
VL 99
IS 28
AR 21148
DI 10.1097/MD.0000000000021148
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MX1UD
UT WOS:000557511400097
PM 32664147
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Qu, WR
   Pan, JB
   Jin, HJ
   Wang, XJ
   Tian, H
AF Qu, Wenrui
   Pan, Junbo
   Jin, Hongjuan
   Wang, Xuejie
   Tian, Heng
TI Acute compartment syndrome secondary to anterolateral thigh flap
   harvesting in a pediatric patient A case report
SO MEDICINE
LA English
DT Article
DE anterolateral thigh flap; compartment syndrome; complications
ID DONOR-SITE COMPLICATIONS; RECONSTRUCTION; DEFECTS
AB Introduction: The anterolateral thigh (ALT) flap is the most popularly used flap for major soft tissue reconstruction. Although it is widely used, acute compartment syndrome (ACS) in pediatric patients has rarely been reported in the literature. We herein reported a case of ACS in a 6-year-old girl after ALT flap harvest with direct closure of the donor site. Patient concerns: A 6-year-old girl was admitted to the Second Hospital of Jilin University with crush injury on the palmar aspect of the right hand and wrist. Diagnosis: Examination showed soft tissue defect of the hand and wrist, damage on the thenar muscles, lightly crushed flexor tendons, crushed median nerve, and ulnar artery thrombosis. Interventions: The defect was closed with an ipsilateral ALT flap measuring 9 cm in length by 6 cm in width. Outcomes: After debridement was performed 3 times, the majority of the rectus femoris and lateral femoris were removed. Secondary closure by skin grafting was performed 2 weeks later. Three days after the procedure, necrotic tissues were noted on the edges of the wound. The diagnosis of ACS of the right was made. A second exploration was decided, and an extensive anterior compartment fasciotomy was performed. After 6 weeks of vacuum sealing drainage therapy, the defect was closed with a free latissimus dorsi musculocutaneous flap. At 4 months of follow-up, the right thigh wound had healed. At 6 months of follow-up, quadriceps muscle weakness remained. At 1 year of follow-up, the patient's mobility had been significantly improved, but diminished sensation remained on the lateral aspect of the thigh. Conclusion: ACS can occur after ALT flap harvesting in pediatric patients and should be recognized as early as possible to avoid devastating complications.
C1 [Qu, Wenrui; Wang, Xuejie; Tian, Heng] Jilin Univ, Hosp 2, Dept Hand Surg, 218 Ziqiang St, Changchun, Jilin, Peoples R China.
   [Pan, Junbo] Yanzhou Univ, Affiliated Hosp, Dept Hand & Foot Surg, Yanzhou, Jiangsu, Peoples R China.
   [Jin, Hongjuan] Jilin Univ, Hosp 1, Dept Plast & Reconstruct Surg, Changchun, Peoples R China.
C3 Jilin University; Yangzhou University; Jilin University
RP Tian, H (通讯作者)，Jilin Univ, Hosp 2, Hand Surg, 218 Ziqiang St,2-11 Bldg,Room 102, Changhun 130000, Jl, Peoples R China.
EM 272033479@qq.com
RI Qu, Wenrui/AAL-9639-2020
OI Qu, Wenrui/0000-0002-0178-3698
CR Acar MA, 2015, J RECONSTR MICROSURG, V31, P225, DOI 10.1055/s-0034-1395888
   Addison PD, 2008, ANN PLAS SURG, V60, P635, DOI 10.1097/SAP.0b013e3181453b7a
   Agostini T, 2013, J CRANIO MAXILL SURG, V41, P15, DOI 10.1016/j.jcms.2012.05.003
   Broom A, 2016, J CHILD ORTHOP, V10, P453, DOI 10.1007/s11832-016-0766-0
   Collins J, 2012, CAN J PLAST SURG, V20, P17, DOI 10.1177/229255031202000103
   Driscoll EBS, 2016, LOCAL REG ANESTH, V9, P65, DOI 10.2147/LRA.S109659
   Flynn JM, 2011, J BONE JOINT SURG AM, V93A, P937, DOI 10.2106/JBJS.J.00285
   Fodor L, 2011, INT J ORAL MAX SURG, V40, P443, DOI 10.1016/j.ijom.2010.10.021
   Gharb BB, 2011, ANN PLAS SURG, V66, P143, DOI 10.1097/SAP.0b013e3181e35e38
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   Kimata Y, 2000, PLAST RECONSTR SURG, V106, P584, DOI 10.1097/00006534-200009030-00009
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   Valentini V, 2008, J CRANIOFAC SURG, V19, P1148, DOI 10.1097/SCS.0b013e3181764ad6
   Yildirim S, 2008, MICROSURG, V28, P99, DOI 10.1002/micr.20458
NR 14
TC 0
Z9 0
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL 10
PY 2020
VL 99
IS 28
AR 21216
DI 10.1097/MD.0000000000021216
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MX1UD
UT WOS:000557511400122
PM 32664172
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Huang, Y
   Hu, JL
   Mao, BQ
   Ni, PW
   Shou, YY
   Hou, LL
   Xie, T
AF Huang, Yao
   Hu, Jiale
   Mao, Beiqian
   Ni, Pengwen
   Shou, Yuyan
   Hou, Lili
   Xie, Ting
TI Perspectives on the Process of Negative Pressure Wound Therapy at Home
   in Patients With Chronic Wound: A Qualitative Descriptive Study
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE wound healing; qualitative research; negative pressure wound therapy;
   home care services
ID PATIENTS EXPERIENCES; CARE; NPWT
AB The purpose of this study was to explore the experience of negative pressure wound therapy (NPWT) at home among Chinese chronic wound patients. Qualitative descriptive study design was adopted, and qualitative data were collected through semistructured in-depth interviews. A purposive, sampling method was used. Informants were recruited from one single wound healing center of a teaching hospital and were interviewed following one course of NPWT at home. A thematic content analysis was undertaken in the framework of input-process-output theory to guide analysis. Of the 13 participants interviewed, 9 were female and 4 were male with an age ranging from 20 to 69 years. Two major categories with their corresponding codes were identified. The first, positive experience, had 6 codes: high-degree identity and feeling hope (input); easy operation and convenience (process); improvement of symptoms and effective treatment (output). The second category, negative experience, had 11 codes: high expenditure, defects of the NPWT device, health education deficiency, and lack of independence and rationales in making decision of NPWT (input); poor communication with wound professionals, unexpected circumstances, therapeutic side effects, and a change of self-image (process); impact on physical symptoms and daily life, impact on social activities, and impact on psychological well-being (output). Patients considered the NPWT at home as a promising regimen, but they also had a feeling of not being prepared and lack of health education to make medical decision independently. The participants' perceptions and experiences would provide valuable information to promote the intervention program of health education and advance service process optimization.
C1 [Huang, Yao; Mao, Beiqian; Ni, Pengwen; Shou, Yuyan; Xie, Ting] Shanghai Jiao Tong Univ, Emergency Dept, Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China.
   [Huang, Yao] Shanghai Jiao Tong Univ, Sch Nursing, Shanghai, Peoples R China.
   [Hu, Jiale] Virginia Commonwealth Univ, Dept Nurse Anesthesia, Richmond, VA 23284 USA.
   [Hou, Lili] Shanghai Jiao Tong Univ, Dept Nursing, Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Virginia
   Commonwealth University; Shanghai Jiao Tong University
RP Hou, LL (通讯作者)，Shanghai Jiao Tong Univ, Dept Nursing, Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China.; Xie, T (通讯作者)，Shanghai Jiao Tong Univ, Wound Healing Ctr, Emergency Dept, Ninth Peoples Hosp,Sch Med, 166 Yan Zhen Rd, Shanghai 200125, Peoples R China.
EM houlili1977@hotmail.com; doctortingxie@139.com
RI Hu, Jiale/I-3949-2019
FU Gaoyuan Nursing Grant Support of Shanghai Municipal Education Commission
   [hlgy1904dxk]; Shanghai Jiao Tong University School of MedicineNursing
   Research Project [Jyh1905]; National Natural Science Foundation of China
   [81671917]; Nursing Research Project of Ninth People's Hospital
   Affiliated to Shanghai Jiao Tong University School of Medicine
   [JYHL20193D06]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   program was supported by grants from Gaoyuan Nursing Grant Support of
   Shanghai Municipal Education Commission (hlgy1904dxk), Shanghai Jiao
   Tong University School of MedicineNursing Research Project (Jyh1905),
   Nursing Research Project of Ninth People's Hospital Affiliated to
   Shanghai Jiao Tong University School of Medicine (JYHL20193D06), and the
   National Natural Science Foundation of China (81671917).
CR Abbotts Joanne, 2010, Br J Nurs, V19, pS37
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NR 32
TC 6
Z9 8
U1 0
U2 18
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2022
VL 21
IS 4
BP 384
EP 396
AR 1534734620946577
DI 10.1177/1534734620946577
EA AUG 2020
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 6H4QA
UT WOS:000558322100001
PM 32772902
DA 2026-07-24
ER
PT J
AU Peters, EJG
   Lipsky, BA
   Senneville, E
   Abbas, ZG
   Aragon-Sanchez, J
   Diggle, M
   Embil, JM
   Kono, S
   Lavery, LA
   Malone, M
   Urbancic-Rovan, V
   Van Asten, SA
AF Peters, Edgar J. G.
   Lipsky, Benjamin A.
   Senneville, Eric
   Abbas, Zulfiqarali G.
   Aragon-Sanchez, Javier
   Diggle, Mathew
   Embil, John M.
   Kono, Shigeo
   Lavery, Lawrence A.
   Malone, Matthew
   Urbancic-Rovan, Vilma
   Van Asten, Suzanne A.
TI Interventions in the management of infection in the foot in diabetes: a
   systematic review
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE antibiotics; diabetes mellitus; diabetic foot infection; osteomyelitis;
   surgery; systematic review
ID COLONY-STIMULATING FACTOR; SKIN-STRUCTURE INFECTIONS;
   ANTIBIOTIC-THERAPY; COMPLICATED SKIN; CONTROLLED-TRIAL; DOUBLE-BLIND;
   OPEN-LABEL; PIPERACILLIN-TAZOBACTAM; ADJUNCTIVE THERAPY; INTRAVENOUS
   ANTIBIOTICS
AB The optimal approaches to managing diabetic foot infections remain a challenge for clinicians. Despite an exponential rise in publications investigating different treatment strategies, the various agents studied generally produce comparable results, and high-quality data are scarce. In this systematic review, we searched the medical literature using the PubMed and Embase databases for published studies on the treatment of diabetic foot infections as of June 2018. This systematic review is an update of previous reviews, the first of which was undertaken in 2010 and the most recent in 2014, by the infection committee of the International Working Group of the Diabetic Foot. We defined the context of literature by formulating clinical questions of interest, then developing structured clinical questions (PICOs) to address these. We only included data from controlled studies of an intervention to prevent or cure a diabetic foot infection. Two independent reviewers selected articles for inclusion and then assessed their relevant outcomes and the methodological quality. Our literature search identified a total of 15327 articles, of which we selected 48 for full-text review; we added five more studies discovered by means other than the systematic literature search. Among these selected articles were 11 high-quality studies published in the last 4years and two Cochrane systematic reviews. Overall, the outcomes in patients treated with the different antibiotic regimens for both skin and soft tissue infection and osteomyelitis of the diabetic foot were broadly equivalent across studies, except that treatment with tigecycline was inferior to ertapenem (+/- vancomycin). Similar outcomes were also reported in studies comparing primarily surgical and predominantly antibiotic treatment strategies in selected patients with diabetic foot osteomyelitis. There is insufficient high-quality evidence to assess the effect of various adjunctive therapies, such as negative pressure wound therapy, topical ointments or hyperbaric oxygen, on infection related outcomes of the diabetic foot. In general, the quality of more recent trial designs are better in past years, but there is still a great need for further well-designed trials to produce higher quality evidence to underpin our recommendations.
C1 [Peters, Edgar J. G.] Vrije Univ Amsterdam, Amsterdam UMC, Dept Internal Med, Amsterdam Infect & Immun Inst, NL-1117 Amsterdam, Netherlands.
   [Lipsky, Benjamin A.] Univ Washington, Dept Med, Seattle, WA USA.
   [Senneville, Eric] Univ Lille, Gustave Dron Hosp, Lille, France.
   [Abbas, Zulfiqarali G.] Muhimbili Univ Hlth & Allied Sci, Abbas Med Ctr, Dar Es Salaam, Tanzania.
   [Aragon-Sanchez, Javier] La Paloma Hosp, Las Palmas Gran Canaria, Spain.
   [Diggle, Mathew] Univ Alberta Hosp, Alberta Publ Labs, Edmonton, AB, Canada.
   [Embil, John M.] Univ Manitoba, Winnipeg, MB, Canada.
   [Kono, Shigeo] Kyoto Med Ctr, Natl Hosp Org, WHO Collaborating Ctr Diabet, Kyoto, Japan.
   [Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
   [Lavery, Lawrence A.] Parkland Hosp, Dallas, TX USA.
   [Malone, Matthew] Western Sydney Univ, Sch Med Infect Dis & Microbiol, South West Sydney Local Hlth Dist, Sydney, NSW, Australia.
   [Urbancic-Rovan, Vilma] Univ Ljubljana, Univ Med Ctr, Fac Med, Ljubljana, Slovenia.
   [Urbancic-Rovan, Vilma] Univ Ljubljana, Fac Med, Ljubljana, Slovenia.
   [Van Asten, Suzanne A.] Leiden Univ, Med Ctr, Dept Med Microbiol, Leiden, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Washington; University of
   Washington Seattle; Universite de Lille; Muhimbili University of Health
   & Allied Sciences; University of Alberta; University of Manitoba;
   University of Texas System; University of Texas Southwestern Medical
   Center; Western Sydney University; South Western Sydney Local Health
   District; University of Ljubljana; University Medical Centre Ljubljana;
   University of Ljubljana; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC)
RP Peters, EJG (通讯作者)，Amsterdam UMC, VUmc, Dept Internal Med, Room ZH4A46,Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
EM e.peters@amsterdamumc.nl
RI Peters, Edgar/B-7790-2014; Aragón-Sánchez, Javier/AAR-9727-2021; Diggle,
   Mathew/JLK-9789-2023; Van Asten, Suzanne/OYE-3899-2025; Lipsky,
   Benjamin/IZE-0823-2023
OI Peters, Edgar/0000-0002-3410-1227; senneville, eric/0000-0002-5720-8908;
   Aragón-Sánchez, Javier/0000-0001-6307-5040; van Asten,
   Suzanne/0000-0002-2753-4577; Lavery, Lawrence/0000-0002-7920-9952; 
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NR 75
TC 42
Z9 49
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAR
PY 2020
VL 36
SU 1
DI 10.1002/dmrr.3282
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MZ6RW
UT WOS:000559257300034
PM 32176437
OA Green Submitted, Green Published, Bronze
DA 2026-07-24
ER
PT J
AU Rayman, G
   Vas, P
   Dhatariya, K
   Driver, V
   Hartemann, A
   Londahl, M
   Piaggesi, A
   Apelqvist, J
   Attinger, C
   Game, F
AF Rayman, Gerry
   Vas, Prashanth
   Dhatariya, Ketan
   Driver, Vickie
   Hartemann, Agnes
   Londahl, Magnus
   Piaggesi, Alberto
   Apelqvist, Jan
   Attinger, Chris
   Game, Fran
CA Int Working Grp Diab Foot
TI Guidelines on use of interventions to enhance healing of chronic foot
   ulcers in diabetes (IWGDF 2019 update)
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE diabetic foot; dressing; foot ulcer; guidelines; wound healing
ID PRESSURE WOUND THERAPY; HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED
   CLOSURE; AMNIOTIC MEMBRANE ALLOGRAFT; CONTROLLED CLINICAL-TRIAL;
   LOWER-EXTREMITY ULCERS; PLATELET-RICH PLASMA; LEVEL LASER THERAPY;
   DOUBLE-BLIND; GROWTH-FACTOR
AB The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of the literature centred on the following: the Population (P), Intervention (I), Comparator (C) and Outcomes (O) framework; the use of the SIGN guideline/Cochrane review system; and the 21 point scoring system advocated by IWGDF/EWMA. This has resulted in 13 recommendations. The recommendation on sharp debridement and the selection of dressings remain unchanged from the last recommendations published in 2016. The recommendation to consider negative pressure wound therapy in post-surgical wounds and the judicious use of hyperbaric oxygen therapy in certain non-healing ischaemic ulcers also remains unchanged. Recommendations against the use of growth factors, autologous platelet gels, bioengineered skin products, ozone, topical carbon dioxide, nitric oxide or interventions reporting improvement of ulcer healing through an alteration of the physical environment or through other systemic medical or nutritional means also remain. New recommendations include consideration of the use of sucrose-octasulfate impregnated dressings in difficult to heal neuro-ischaemic ulcers and consideration of the use of autologous combined leucocyte, platelet and fibrin patch in ulcers that are difficult to heal, in both cases when used in addition to best standard of care. A further new recommendation is the consideration of topical placental derived products when used in addition to best standard of care.
C1 [Rayman, Gerry] East Suffolk & North East Essex Fdn Trust, Diabet Ctr, Colchester, Essex, England.
   [Rayman, Gerry] East Suffolk & North East Essex Fdn Trust, Res Unit, Colchester, Essex, England.
   [Vas, Prashanth] Kings Coll Hosp London, Diabet Foot Clin, London, England.
   [Dhatariya, Ketan] Norfolk & Norwich Univ Hosp NHS Fdn Trust, Dept Diabet, Norwich, Norfolk, England.
   [Dhatariya, Ketan] Univ East Anglia, Norwich, Norfolk, England.
   [Driver, Vickie] Brown Univ, Sch Med, Providence, RI 02912 USA.
   [Hartemann, Agnes] Paris 6 Univ, ICAN, Pitie Salpetriere Hosp, APHP, Paris, France.
   [Londahl, Magnus] Skane Univ Hosp, Dept Endocrinol, Lund, Sweden.
   [Londahl, Magnus] Lund Univ, Dept Clin Sci, Lund, Sweden.
   [Piaggesi, Alberto] Univ Pisa, Diabet Foot Sect, Dept Med, Pisa, Italy.
   [Apelqvist, Jan] Malmo Univ Hosp, Dept Endocrinol, Malmo, Sweden.
   [Attinger, Chris] Medstar Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
   [Game, Fran] Univ Hosp Derby & Burton NHS Fdn, Dept Diabet & Endocrinol, Derby, England.
C3 King's College Hospital NHS Foundation Trust; King's College Hospital;
   Norfolk & Norwich University Hospitals NHS Foundation Trust; University
   of East Anglia; Brown University; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Hotel-Dieu - APHP;
   Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite;
   Institut National de la Sante et de la Recherche Medicale (Inserm); Lund
   University; Skane University Hospital; Lund University; University of
   Pisa; Lund University; Skane University Hospital; Georgetown University
RP Rayman, G (通讯作者)，East Suffolk & North Essex NHS Fdn, Ipswich Diabet Ctr, TrustHeath Rd, Colchester IP4 5PD, Essex, England.
EM Gerry.Rayman@esneft.nhs.uk
RI ; Rayman, Gerry/KLZ-2200-2024
OI Game, Frances/0000-0002-5294-4789; Vas, Prashanth/0000-0001-7448-2995;
   Löndahl, Magnus/0000-0003-1522-3920
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NR 121
TC 152
Z9 189
U1 2
U2 64
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAR
PY 2020
VL 36
SU 1
DI 10.1002/dmrr.3283
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MZ6RW
UT WOS:000559257300035
PM 32176450
OA Bronze
DA 2026-07-24
ER
PT J
AU Vas, P
   Rayman, G
   Dhatariya, K
   Driver, V
   Hartemann, A
   Londahl, M
   Piaggesi, A
   Apelqvist, J
   Attinger, C
   Game, F
AF Vas, Prashanth
   Rayman, Gerry
   Dhatariya, Ketan
   Driver, Vickie
   Hartemann, Agnes
   Londahl, Magnus
   Piaggesi, Alberto
   Apelqvist, Jan
   Attinger, Chris
   Game, Fran
TI Effectiveness of interventions to enhance healing of chronic foot ulcers
   in diabetes: a systematic review
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE debridement; diabetic foot; dressing; foot ulcer; guidelines; hyperbaric
   oxygen; negative pressure wound therapy; placental-derived products;
   topical oxygen; wound healing
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; COLONY-STIMULATING
   FACTOR; VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; CONTROLLED
   CLINICAL-TRIAL; EPIDERMAL-GROWTH-FACTOR; CRITICAL LIMB ISCHEMIA;
   INTERMITTENT PNEUMATIC COMPRESSION; AMNIOTIC MEMBRANE ALLOGRAFT
AB The management of diabetic foot ulcers (DFU) remains a challenge, and there is continuing uncertainty concerning optimal approaches to wound healing. The International Working Group of the Diabetic Foot (IWGDF) working group on wound healing has previously published systematic reviews of the evidence in 2008, 2012 and 2016 to inform protocols for routine care and to highlight areas which should be considered for further study. The working group has now updated this review by considering papers on the interventions to improve the healing of DFU's published between June 2014 and August 2018. Methodological quality of selected studies was independently assessed by a minimum of two reviewers using the recently published 21-point questionnaire as recommended by IWGDF/European Wound Management Association, as well as the previously incorporated Scottish Intercollegiate Guidelines Network criteria. Of the 2275 papers identified, 97 were finally selected for grading following full text review. Overall, there has been an improvement in study design and a significant rise in the number of published studies. While previous systematic reviews did not find any evidence to justify the use of newer therapies, except for negative pressure wound therapy in post-surgical wounds, in this review we found additional evidence to support some interventions including a sucrose-octasulfate dressing, the combined leucocyte, fibrin and platelet patch as well as topical application of some placental membrane products, all when used in addition to usual best care. Nonetheless, the assessment and comparison of published trials remains difficult with marked clinical heterogeneity between studies: in patient selection, study duration, standard of usual care provision and the timing and description of the clinical endpoints.
C1 [Vas, Prashanth] Kings Coll Hosp London, Diabet Foot Clin, London, England.
   [Rayman, Gerry] East Suffolk & North East Essex Fdn Trust, Diabet Ctr, Colchester, Essex, England.
   [Rayman, Gerry] East Suffolk & North East Essex Fdn Trust, Res Unit, Colchester, Essex, England.
   [Dhatariya, Ketan] Univ East Anglia, Norfolk & Norwich Univ Hosp NHS Fdn Trust, Dept Diabet, Norwich, Norfolk, England.
   [Driver, Vickie] Brown Univ, Sch Med, Providence, RI 02912 USA.
   [Hartemann, Agnes] Hop La Pitie Salpetriere, APHP, Paris, France.
   [Londahl, Magnus] ICAN, Lyon, France.
   [Londahl, Magnus] Lund Univ, Dept Endocrinol, Skane Univ Hosp, Lund, Sweden.
   [Londahl, Magnus] Lund Univ, Dept Clin Sci, Lund, Sweden.
   [Piaggesi, Alberto] Univ Pisa, Diabet Foot Sect, Dept Med, Pisa, Italy.
   [Apelqvist, Jan] Univ Hosp Malmo, Dept Endocrinol, Malmo, Sweden.
   [Attinger, Chris] Medstar Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
   [Game, Fran] Univ Hosp Derby & Burton NHS Fdn Trust, Dept Diabet & Endocrinol, Derby, England.
C3 King's College Hospital NHS Foundation Trust; King's College Hospital;
   University of East Anglia; Norfolk & Norwich University Hospitals NHS
   Foundation Trust; Brown University; Sorbonne Universite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Ambroise-Pare -
   APHP; Hopital Universitaire Pitie-Salpetriere - APHP; Universite Paris
   Cite; Hopital Universitaire Hotel-Dieu - APHP; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Lund University; Skane
   University Hospital; Lund University; University of Pisa; Lund
   University; Skane University Hospital; Georgetown University
RP Vas, P (通讯作者)，Kings Coll Hosp London, Diabet Foot Clin, London, England.
EM prashanth.vas@nhs.net
RI ; Rayman, Gerry/KLZ-2200-2024
OI Löndahl, Magnus/0000-0003-1522-3920; Vas, Prashanth/0000-0001-7448-2995;
   Game, Frances/0000-0002-5294-4789
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NR 235
TC 63
Z9 78
U1 2
U2 36
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAR
PY 2020
VL 36
SU 1
DI 10.1002/dmrr.3284
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MZ6RW
UT WOS:000559257300036
PM 32176446
OA Bronze
DA 2026-07-24
ER
PT J
AU Katzengold, R
   Orlov, A
   Gefen, A
AF Katzengold, Rona
   Orlov, Alexey
   Gefen, Amit
TI A novel system for dynamic stretching of cell cultures reveals the
   mechanobiology for delivering better negative pressure wound therapy
SO BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
LA English
DT Article
DE Chronic and acute wound healing; Scratch wound assay; Cell biomechanics;
   Surgical wounds; Tissue repair
ID MESENCHYMAL STEM-CELLS; CYCLIC STRETCH; IN-VITRO; MIGRATION; FIBROBLAST;
   PROLIFERATION; STIMULATION; KINEMATICS; STRAINS; TENSILE
AB Serious wounds, both chronic and acute (e.g., surgical), are among the most common, expensive and difficult-to-treat health problems. Negative pressure wound therapy (NPWT) is considered a mainstream procedure for treating both wound types. Soft tissue deformation stimuli are the crux of NPWT, enhancing cell proliferation and migration from peri-wound tissues which contributes to healing. We developed a dynamic stretching device (DSD) contained in a miniature incubator for applying controlled deformations to fibroblast wound assays. Prior to the stretching experiments, fibroblasts were seeded in 6-well culture plates with elastic substrata and let to reach confluency. Squashing damage was then induced at the culture centers, and the DSD was activated to deliver stretching regimes that represented common clinical NPWT protocols at two peak strain levels, 0.5% and 3%. Analyses of the normalized maximal migration rate (MMR) data for the collective cell movement revealed that for the 3% strain level, the normalized MMR of cultures subjected to a 0.1 Hz stretch frequency regime was similar to 1.4 times and statistically significantly greater (p < 0.05) than that of the cultures subjected to no-stretch (control) or to static stretch (2nd control). Correspondingly, analysis of the time to gap closure data indicated that the closure time of the wound assays subjected to the 0.1 Hz regime was similar to 30% shorter than that of the cultures subjected to the control regimes (p < 0.05). Other simulated NPWT protocols did not emerge as superior to the controls. The present method and system are a powerful platform for further revealing the mechanobiology of NPWT and for improving this technology.
C1 [Katzengold, Rona; Orlov, Alexey; Gefen, Amit] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, Herbert J Berman Chair Vasc Bioengn, IL-6997801 Tel Aviv, Israel.
C3 Tel Aviv University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Dept Biomed Engn, Herbert J Berman Chair Vasc Bioengn, IL-6997801 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
OI Gefen, Amit/0000-0002-0223-7218
FU Israel Science Foundation [1266/16]; European Union's Horizon 2020
   research and innovation programme under the Marie Sklodowska-Curie grant
   [811965]
FX We would like to thank Mr. Jelle van Orsouw from Eindhoven University of
   Technology and Dr. Uri Zaretsky from our Department of Biomedical
   Engineering at Tel Aviv University for their help regarding the
   development of the cell stretching apparatus and experimental work. This
   research work was partially supported by the Israel Science Foundation
   Grant No. 1266/16 and by the European Union's Horizon 2020 research and
   innovation programme under the Marie Sklodowska-Curie grant Agreement
   No. 811965.
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PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1617-7959
EI 1617-7940
J9 BIOMECH MODEL MECHAN
JI Biomech. Model. Mechanobiol.
PD FEB
PY 2021
VL 20
IS 1
BP 193
EP 204
DI 10.1007/s10237-020-01377-6
EA AUG 2020
PG 12
WC Biophysics; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Engineering
GA QJ2PR
UT WOS:000559691100001
PM 32803464
DA 2026-07-24
ER
PT J
AU Liguori, G
   Papa, G
   Boltri, M
   Stocco, C
   De Grazia, A
   Rizzo, M
   Pavan, N
   Ramella, V
   Trombetta, C
   Arnez, ZM
AF Liguori, Giovanni
   Papa, Giovanni
   Boltri, Matteo
   Stocco, Chiara
   De Grazia, Alessia
   Rizzo, Michele
   Pavan, Nicola
   Ramella, Vittorio
   Trombetta, Carlo
   Arnez, Zoran Marij
TI Reconstruction of penile skin loss using a combined therapy of negative
   pressure wound therapy, dermal regeneration template, and
   split-thickness skin graft application
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
ID MANAGEMENT; SHAFT
AB This study evaluates the use of acellular dermal matrix (ADM) in conjunction with negative pressure wound therapy (NPWT) and delayed split-thickness skin graft (STSG) application as an alternative to free tissue transfer for defect coverage of the penile shaft. Five patients with genital lymphedema and one with penile skin deficiency underwent penile shaft reconstruction with a two-stage surgical procedure. The first procedure aimed to the correction of skin defect and to neodermis regeneration through the use of an ADM (Integra (R), Integra Lifesciences Corp., Plainsboro, NJ, USA) and NPWT. The second procedure 3 weeks later aimed to the covering of the skin defect with an unmeshed STSG. Both the Integra and skin graft showed completely taking at 7 days postop. No major complications occurred. At 6 months grafts gained sufficient elasticity to allow the sliding of the epidermis over the dermal layer, similarly the physiological penile shaft skin. Our results suggest that combined therapy might be an alternative to free tissue transfer for defect coverage of the penile shaft, leading to a good esthetic result, an optimal shaft coverage and providing adequate extensibility during erections. For best results we advise that in these cases urologists should collaborate with plastic surgeons.
C1 [Liguori, Giovanni; Boltri, Matteo; Rizzo, Michele; Pavan, Nicola; Trombetta, Carlo] Univ Trieste, Dept Urol, Trieste, Italy.
   [Papa, Giovanni; Stocco, Chiara; De Grazia, Alessia; Ramella, Vittorio; Arnez, Zoran Marij] Univ Trieste, Dept Plast Surg, Trieste, Italy.
C3 University of Trieste; University of Trieste
RP Liguori, G (通讯作者)，Univ Trieste, Dept Urol, Trieste, Italy.
EM gioliguori33@gmail.com
RI Pavan, Nicola/V-9850-2019; Boltri, Matteo/AHD-7996-2022; liguori,
   giovanni/U-8792-2019; Arnez, Zoran/AAA-2112-2019; Ramella,
   Vittorio/AAU-3267-2021
OI Boltri, Matteo/0000-0002-5177-6445; RIZZO, MICHELE/0000-0001-5074-2043;
   liguori, giovanni/0000-0003-2431-5296; 
CR Alei G, 2012, J SEX MED, V9, P1945, DOI 10.1111/j.1743-6109.2012.02744.x
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NR 25
TC 4
Z9 4
U1 0
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD DEC
PY 2021
VL 33
IS 8
BP 854
EP 859
DI 10.1038/s41443-020-00343-1
EA AUG 2020
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA YP9AK
UT WOS:000560450200001
PM 32801347
DA 2026-07-24
ER
PT J
AU Grande, R
   Fiori, G
   Russo, G
   Fioramonti, P
   Campagnol, M
   di Marzo, L
AF Grande, Raffaele
   Fiori, Giulia
   Russo, Giulia
   Fioramonti, Paolo
   Campagnol, Monica
   di Marzo, Luca
TI A multistage combined approach to promote diabetic wound healing in
   COVID-19 era
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE CLI; diabetes mellitus; non-healing ulcers; NPWT; PRP
ID PLATELET-RICH PLASMA; OZONE-THERAPY; SURGICAL REVASCULARIZATION; LEG
   ULCERS; FOOT; METALLOPROTEINASES; EFFICACY; CARE
AB When diabetes mellitus is not properly controlled with drugs and a healthy lifestyle, it exposes patients with advanced peripheral arterial disease or critical limb ischaemia (CLI) to the most serious complications, in particular lower limb ulcers. Surgical or endovascular treatments represent the first line of intervention; in addition, the adequate management of ulcers can guarantee not only a faster wound healing but also the improvement of the patient's prognosis. To speed up this process, negative pressure wound therapy (NPWT), platelet-rich plasma (PRP), and other advanced moist wound dressing have been proposed. During Coronavirus disease 2019 (COVID-19) pandemic, many patients with CLI and diabetes mellitus had difficult access to advanced treatments with a significant reduction in life expectancy. We report the cases of patients with non-healing ulcers and CLI treated with an empiric multistage approach after successful endovascular revascularisation; the postoperative course was eventful in all patients, and foot ulcers are currently in an advanced state of healing. The association between adequate revascularisation, systemic anti-inflammatory, and antibiotic therapy with the multistage advanced medications ensures healing of ulcers, limb salvage, and improvement of patient prognosis.
C1 [Grande, Raffaele; Fiori, Giulia; Russo, Giulia; Fioramonti, Paolo; Campagnol, Monica; di Marzo, Luca] Sapienza Univ Rome, Dept Surg Pietro Valdoni, Rome, Italy.
C3 Sapienza University Rome
RP Grande, R (通讯作者)，Sapienza Univ Rome, Dept Surg Pietro Valdoni, Policlin Umberto I, Viale Policlin 151, I-00161 Rome, Italy.
EM raffaele.eia@alice.it
RI ; Grande, Raffaele/AAO-1388-2020
OI di Marzo, Luca/0000-0002-2956-6257; Fiori, Giulia/0009-0001-5062-4829;
   Grande, Raffaele/0000-0003-2873-0104
CR Ammendola M, 2017, INT WOUND J, V14, P9, DOI 10.1111/iwj.12682
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NR 38
TC 5
Z9 5
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2020
VL 17
IS 6
BP 1863
EP 1870
DI 10.1111/iwj.13476
EA AUG 2020
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA PE3BU
UT WOS:000561059400001
PM 32820598
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Iwasaki, R
   Motomura, H
   Hatano, T
   Sakahara, D
   Fujii, N
AF Iwasaki, Rie
   Motomura, Hisashi
   Hatano, Takaharu
   Sakahara, Daisuke
   Fujii, Naho
TI Reconstruction of Pelvic Exenteration Defects Using the Combined Method
   With Extended Vertical Rectus Abdominus Flap and Vacuum- Assisted
   Suction Drainage
SO INTERNATIONAL SURGERY
LA English
DT Article
DE Reconstruction; Rectus abdominus flap; Suction drain; Negative pressure
   wound therapy (NPWT)
ID THERAPY; FLOOR
AB Introduction: Pelvic exenteration is a highly invasive procedure, with a reported rate of 20%-80% for serious complications. Thus, the prevention of postoperative complications is a major issue. Many previous reports have emphasized the importance of filling the dead space to prevent postoperative complications. In addition to filling the dead space, we believe that achieving sufficient drainage is extremely important. In this paper, we present a new combined method of the extended rectus abdominis myocutaneous flap and vacuum drainage with multiple drains, which achieved a lower frequency of complications.
   Case Presentation: The subjects were 6 patients who underwent reconstruction following pelvic exenteration during a 7-year period between April 2005 and September 2013. We retrospectively measured the volume of the pelvic cavity and that of the rectus abdominis flap on lateral computed tomography (CT) scans to calculate the percentage of the dead space that was filled by the flap. There were no problems with flap engraftment in any of the patients. There were no serious complications, and no patient required additional surgery. The percentage of the dead space filled ranged from 25% to 46% (mean: 32%).
   Conclusion: The rectus flap + vacuum drainage method, which uses an extended rectus abdominis myocutaneous flap to decrease the pelvic dead space and multiple vacuum suction drains, was associated with the prevention of serious complications.
C1 [Iwasaki, Rie; Motomura, Hisashi; Hatano, Takaharu; Sakahara, Daisuke; Fujii, Naho] Osaka City Univ, Dept Plast & Reconstruct Surg, Grad Sch Med, Osaka, Japan.
C3 Osaka Metropolitan University
RP Motomura, H (通讯作者)，Osaka City Univ, Dept Plast & Reconstruct Surg, Grad Sch Med, Abeno Ku, Asahi 1-4-3, Osaka 5458585, Japan.
EM motomura@med.osaka-cu.ac.jp
CR Cibula D, 2017, GYNECOL ONCOL, V144, P558, DOI 10.1016/j.ygyno.2017.01.014
   di Summa PG, 2016, J PLAST RECONSTR AES, V69, P359, DOI 10.1016/j.bjps.2015.10.044
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NR 11
TC 2
Z9 2
U1 0
U2 1
PU INT COLLEGE OF SURGEONS
PI CHICAGO
PA 1516 N LAKE SHORE DR, CHICAGO, IL 60610 USA
SN 0020-8868
J9 INT SURG
JI Int. Surg.
PD MAR-APR
PY 2019
VL 104
IS 3-4
BP 138
EP 142
DI 10.9738/INTSURG-D-17-00105.1
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NC6XC
UT WOS:000561359300009
OA gold
DA 2026-07-24
ER
PT J
AU Drerup, C
   Schlarb, D
AF Drerup, Christian
   Schlarb, Dominik
TI Surgical treatment for chronic leg ulcer
SO HAUTARZT
LA German
DT Article
DE Split-thickness skin graft; Mesh graft; Negative pressure wound therapy;
   Ulcer therapy; Wound healing
ID PRESSURE WOUND THERAPY; THICKNESS SKIN-GRAFT
AB Leg ulcers pose a therapeutic challenge due to a chronic healing process. Conservative wound dressings are initially the treatment of choice, but their effectiveness in therapy-refractory wounds is limited. In these cases, multiple mechanical debridement in combination with split-thickness skin grafts (STSG) are a simple and safe treatment option for ulcer coverage. Additional therapy with negative pressure wound therapy (NPWT) improves the surgical outcome by promoting ulcer granulation, continuous elimination of exsudate and blood as well as increased contact pressure on the skin graft. After transplantation, the split skin graft requires daily wound dressings until it has fully healed after approximately 3 weeks.
C1 [Drerup, Christian; Schlarb, Dominik] Univ Klinikum Munster, Klin Hautkrankheiten Allgemeine Dermatol & Venero, Von Esmarch Str 58, D-48149 Munster, Germany.
C3 University of Munster
RP Schlarb, D (通讯作者)，Univ Klinikum Munster, Klin Hautkrankheiten Allgemeine Dermatol & Venero, Von Esmarch Str 58, D-48149 Munster, Germany.
EM Dominik.Schlarb@ukmuenster.de
CR Andreassi A, 2005, CLIN DERMATOL, V23, P332, DOI 10.1016/j.clindermatol.2004.07.024
   Dissemond J, 2020, HAUTARZT, V71, P301, DOI 10.1007/s00105-020-04554-x
   Dissemond J, 2017, J DTSCH DERMATOL GES, V15, P443, DOI 10.1111/ddg.13215
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NR 13
TC 1
Z9 1
U1 0
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0017-8470
EI 1432-1173
J9 HAUTARZT
JI Hautarzt
PD SEP
PY 2020
VL 71
IS 9
SI SI
BP 715
EP 723
DI 10.1007/s00105-020-04661-9
EA AUG 2020
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA NJ0ZK
UT WOS:000561691500001
PM 32827047
DA 2026-07-24
ER
PT J
AU Png, ME
   Madan, JJ
   Dritsaki, M
   Achten, J
   Parsons, N
   Fernandez, M
   Grant, R
   Nanchahal, J
   Costa, ML
AF Png, M. E.
   Madan, J. J.
   Dritsaki, M.
   Achten, J.
   Parsons, N.
   Fernandez, M.
   Grant, R.
   Nanchahal, J.
   Costa, M. L.
CA WHiST Trial Collaborators
TI Cost-utility analysis of standard dressing compared with incisional
   negative-pressure wound therapy among patients with closed surgical
   wounds following major trauma to the lower limb
SO BONE & JOINT JOURNAL
LA English
DT Article
AB Aims
   To compare the cost-utility of standard dressing with incisional negative-pressure wound therapy (iNPWT) in adults with closed surgical wounds associated with major trauma to the lower limbs.
   Methods
   A within-trial economic evaluation was conducted from the UK NHS and personal social services (PSS) perspective based on data collected from the Wound Healing in Surgery for Trauma (WHiST) multicentre randomized clinical trial. Health resource utilization was collected over a six-month post-randomization period using trial case report forms and participant-completed questionnaires. Cost-utility was reported in terms of incremental cost per quality-adjusted life year (QALY) gained. Sensitivity analysis was conducted to test the robustness of cost-effectiveness estimates while uncertainty was handled using confidence ellipses and cost-effectiveness acceptability curves.
   Results
   The incremental cost of standard dressing versus iNPWT over six months was 2,037 pound (95% confidence interval (CI) 349 pound to 3,724) pound. There was an insignificant increment in QALYs gained in the iNPWT group (0.005, 95% CI -0.018 to 0.028). The probability of iNPWT being cost-effective at 20,000 pound per QALY was 1.9%. The results remained robust in the sensitivity analysis.
   Conclusion
   The within-trial economic evaluation suggests that iNPWT is unlikely to be a cost-effective alternative to standard dressing in adults with closed surgical wounds to their lower limbs.
C1 [Png, M. E.] Univ Oxford, Hlth Econ, Nuffield Dept Primary Care Hlth Sci, Oxford, England.
   [Png, M. E.; Dritsaki, M.; Achten, J.; Fernandez, M.; Nanchahal, J.; Costa, M. L.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
   [Madan, J. J.; Parsons, N.; Grant, R.] Univ Oxford, Oxford, England.
   [Madan, J. J.; Parsons, N.] Univ Warwick, Warwick Med Sch, Stat & Epidemiol, Coventry, W Midlands, England.
   [Grant, R.] Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.
C3 University of Oxford; University of Oxford; University of Oxford;
   University of Warwick; University of Warwick
RP Png, ME (通讯作者)，Univ Oxford, Hlth Econ, Nuffield Dept Primary Care Hlth Sci, Oxford, England.; Png, ME (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
EM may.png@phc.ox.ac.uk
RI ; Achten, Juul/KUD-8515-2024; Png, May Ee/AAG-4902-2019; Parsons,
   Nick/AAA-8713-2019
OI Madan, Jason/0000-0003-4316-1480; Achten, Juul/0000-0002-8857-5743;
   Nanchahal, Jagdeep/0000-0002-9579-9411; Costa,
   Matthew/0000-0003-3644-1388; Png, May Ee/0000-0001-5876-9363; Parsons,
   Nick/0000-0001-9975-888X
FU UK National Institute for Health Research Health Technology Assessment
   (HTA) Programme; National Institute for Health Research (NIHR) Oxford
   Biomedical Research Centre; National Institute for Health Research
   [14/199/14] Funding Source: researchfish
FX Although none of the authors has received or will receive benefits for
   personal or professional use from a commercial party related directly or
   indirectly to the subject of this article, benefits have been or will be
   received but will be directed solely to a research fund, foundation,
   educational institution, or other non-profit organization with which one
   or more of the authors are associated. This project was funded by the UK
   National Institute for Health Research Health Technology Assessment
   (HTA) Programme and was supported by the National Institute for Health
   Research (NIHR) Oxford Biomedical Research Centre. The funder has not
   been involved in the design and conduct of the study; collection,
   management, analysis, and interpretation of the data, the preparation,
   review, or approval of the manuscript, nor in the decision to submit the
   manuscript for publication. The views expressed are those of the authors
   and not necessarily those of the NHS, the NIHR or the Department of
   Health. Smith & Nephew provided incisional NPWT dressings (PICO Single
   Use Negative Pressure Wound Therapy System) to recruiting centres for
   the purposes of the trial and had no part in the design, conduct or
   reporting of the study.
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NR 16
TC 14
Z9 15
U1 0
U2 5
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD AUG
PY 2020
VL 102B
IS 8
BP 1072
EP 1081
DI 10.1302/0301-620X.102B8.BJJ-2020-0126.R1
PG 10
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA ND4MO
UT WOS:000561876000014
PM 32731829
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Coccolini, F
   Gubbiotti, F
   Ceresoli, M
   Tartaglia, D
   Fugazzola, P
   Ansaloni, L
   Sartelli, M
   Kluger, Y
   Kirkpatrick, A
   Amico, F
   Catena, F
   Chiarugi, M
AF Coccolini, Federico
   Gubbiotti, Francesca
   Ceresoli, Marco
   Tartaglia, Dario
   Fugazzola, Paola
   Ansaloni, Luca
   Sartelli, Massimo
   Kluger, Yoram
   Kirkpatrick, Andrew
   Amico, Francesco
   Catena, Fausto
   Chiarugi, Massimo
CA IROA Study Grp
TI Open Abdomen and Fluid Instillation in the Septic Abdomen: Results from
   the IROA Study
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID FASCIAL CLOSURE; PERITONEAL RESUSCITATION; MANAGEMENT; PRESSURE; THERAPY
AB Background Open abdomen (OA) is a surgical option that can be used in patients with severe peritonitis. Few evidences exist to recommend the use of intraperitoneal fluid instillation associated with OA in managing septic abdomen. Materials and methods A prospective analysis of adult patients enrolled in the International Register of Open Abdomen (trial registration: NCT02382770) was performed. Results A total of 387 patients were enrolled in two groups: 84 with peritoneal fluid instillation (FI) and 303 without (NFI). The groups were homogeneous for baseline characteristics. Overall complications were 92.9% in FI and 86.3% in NFI (p = 0.106). Complications during OA were 72.6% in FI and 59.9% in NFI (p = 0.034). Complications after definitive closure were 70.8% in FI and 61.1% in NFI (p = 0.133). Entero-atmospheric fistula was 13.1% in FI and 12% in NFI (p = 0.828). Fascial closure was 78.6% in FI and 63.7% in NFI (p = 0.02). Analysis of FI in negative pressure wound therapy (NPWT) showed: Overall morbidity in NPWT was 94% and in non-NPWT 91.2% (p = 0.622) and morbidity during OA was 68% and 79.4% (p = 0.25), respectively. Definitive fascial closure in NPWT was 87.8% and 96.8% in non-NPWT (p = 0.173). Overall mortality was 40% in NPWT and 29.4% in non-NPWT (p = 0.32) and morality during OA period was 18% and 8.8% (p = 0.238), respectively. Conclusion We found intraperitoneal fluid instillation during open abdomen in peritonitic patients to increase the complication rate during the open abdomen period, with no impact on mortality, entero-atmospheric fistula rate and opening time. Fascial closure rate is increased by instillation. Fluid instillation is feasible even when associated with nonnegative pressure temporary abdominal closure techniques.
C1 [Coccolini, Federico; Tartaglia, Dario; Chiarugi, Massimo] Pisa Univ Hosp, Gen Emergency & Trauma Surg Dept, Via Paradisia 1, I-56124 Pisa, Italy.
   [Gubbiotti, Francesca] Ancona Hosp, Gen Surg Dept, Ancona, Italy.
   [Ceresoli, Marco] Milano Bicocca Univ Hosp, Gen & Emergency Surg Dept, Monza, Italy.
   [Fugazzola, Paola; Ansaloni, Luca] Bufalini Hosp, Gen Emergency & Trauma Surg Dept, Cesena, Italy.
   [Sartelli, Massimo] Macerata Hosp, Gen & Emergency Surg Dept, Macerata, Italy.
   [Kluger, Yoram] Rambam Med Ctr, Gen Surg Dept, Tel Aviv, Israel.
   [Kirkpatrick, Andrew] Foothills Med Ctr, Dept Surg, Calgary, AB, Canada.
   [Amico, Francesco] Univ Newcastle, John Hunter Hosp, Dept Surg, Trauma Serv, Newcastle, NSW, Australia.
   [Catena, Fausto] Parma Univ Hosp, Emergency Surg Dept, Parma, Italy.
C3 University of Pisa; Azienda Ospedaliero Universitaria Pisana; Technion
   Israel Institute of Technology; Rambam Health Care Campus; University of
   Calgary; University Calgary Hospital; John Hunter Hospital; University
   of Newcastle; University of Parma; University Hospital of Parma
RP Coccolini, F (通讯作者)，Pisa Univ Hosp, Gen Emergency & Trauma Surg Dept, Via Paradisia 1, I-56124 Pisa, Italy.
EM federico.coccolini@gmail.com
RI Ansaloni, Luca/AAJ-6507-2020; /AAD-7440-2020; Tartaglia,
   Dario/AAJ-1735-2020; Ceresoli, Marco/GMW-5356-2022; Fugazzola,
   Paola/AAH-4680-2019; Chiarugi, Massimo/ABQ-7280-2022; Ansaloni,
   Luca/AAP-9134-2020
OI Ansaloni, Luca/0000-0001-6427-0307; Fugazzola,
   Paola/0000-0002-6227-9276; amico, francesco/0000-0002-8217-9379;
   Chiarugi, Massimo/0000-0001-6905-2499; Ansaloni,
   Luca/0000-0001-6427-0307
FU Universita di Pisa within the CRUI-CARE Agreement
FX Open access funding provided by Universita di Pisa within the CRUI-CARE
   Agreement.
CR Alvarez PS, 2018, ANN MED SURG, V36, P246, DOI 10.1016/j.amsu.2018.10.007
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NR 33
TC 8
Z9 14
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD DEC
PY 2020
VL 44
IS 12
BP 4032
EP 4040
DI 10.1007/s00268-020-05728-3
EA AUG 2020
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OI2OY
UT WOS:000562325000001
PM 32833107
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Smolle, MA
   Nischwitz, SP
   Hutan, M
   Trunk, P
   Lumenta, D
   Bernhardt, GA
AF Smolle, Maria A.
   Nischwitz, Sebastian P.
   Hutan, Martin
   Trunk, Primoz
   Lumenta, David
   Bernhardt, Gerwin A.
TI Closed-incision negative-pressure wound management in surgery-literature
   review and recommendations
SO EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
LA English
DT Review
DE Surgical site infection; Negative-pressure wound dressing; ciNPWT; Wound
   healing deficit; Postoperative wound complications
ID SURGICAL SITE INFECTION; RANDOMIZED CLINICAL-TRIAL; FLAP DONOR SITE;
   CARDIAC-SURGERY; REVISION HIP; THERAPY; PREVENTION; SYSTEM;
   COMPLICATIONS; METAANALYSIS
AB Background Wound healing deficits and subsequent surgical site infections are potential complications after surgical procedures, resulting in increased morbidity and treatment costs. Closed-incision negative-pressure wound therapy (ciNPWT) systems seem to reduce postoperative wound complications by sealing the wound and reducing tensile forces. Materials and methods We conducted a collaborative English literature review in the PubMed database including publications from 2009 to 2020 on ciNPWT use in five surgical subspecialities (orthopaedics and trauma, general surgery, plastic surgery, cardiac surgery and vascular surgery). With literature reviews, case reports and expert opinions excluded, the remaining 59 studies were critically summarized and evaluated with regard to their level of evidence. Results Of nine studies analysed in orthopaedics and trauma, positive results of ciNPWT were reported in 55.6%. In 11 of 13 (84.6%), 13 of 15 (86.7%) and 10 of 10 (100%) of studies analysed in plastic, vascular and general surgery, respectively, a positive effect of ciNPWT was observed. On the contrary, only 4 of 12 studies from cardiac surgery discovered positive effects of ciNPWT (33.3%). Conclusion ciNPWT is a promising treatment modality to improve postoperative wound healing, notably when facing increased tensile forces. To optimise ciNPWT benefits, indications for its use should be based on patient- and procedure-related risk factors.
C1 [Smolle, Maria A.; Bernhardt, Gerwin A.] Med Univ Graz, Dept Orthopaed & Trauma, Auenbruggerpl 5, A-8036 Graz, Austria.
   [Nischwitz, Sebastian P.; Lumenta, David] Med Univ Graz, Div Plast Aesthet & Reconstruct Surg, Graz, Austria.
   [Hutan, Martin] Landesklinikum Hainburg, Dept Surg, Hainburg Donau, Austria.
   [Trunk, Primoz] Univ Ljubljana, Dept Cardiovasc Surg, Med Ctr, Ljubljana, Slovenia.
   [Nischwitz, Sebastian P.] JOANNEUM RES Forsch Gesell mbH, COREMED Cooperat Ctr Regenerat Med, Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; University of
   Ljubljana
RP Bernhardt, GA (通讯作者)，Med Univ Graz, Dept Orthopaed & Trauma, Auenbruggerpl 5, A-8036 Graz, Austria.
EM gerwin.bernhardt@medunigraz.at
RI Bernhardt, Gerwin/F-2196-2010; Lumenta, David/AAD-5935-2019
OI Nischwitz, Sebastian P/0000-0002-6621-4891; 
FU Medical University of Graz
FX Open access funding provided by Medical University of Graz.
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NR 84
TC 6
Z9 9
U1 0
U2 6
PU SPRINGER WIEN
PI Vienna
PA Prinz-Eugen-Strasse 8-10, A-1040 Vienna, AUSTRIA
SN 1682-8631
EI 1682-4016
J9 EUR SURG
JI Eur. Surg.
PD DEC
PY 2020
VL 52
IS 6
BP 249
EP 267
DI 10.1007/s10353-020-00657-w
EA AUG 2020
PG 19
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OV9WT
UT WOS:000562351800001
OA hybrid
DA 2026-07-24
ER
PT J
AU Cereatti, F
   Grassia, R
   Drago, A
   Conti, CB
   Donatelli, G
AF Cereatti, Fabrizio
   Grassia, Roberto
   Drago, Andrea
   Conti, Clara Benedetta
   Donatelli, Gianfranco
TI Endoscopic management of gastrointestinal leaks and fistulae: What
   option do we have?
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Leak; Fistula; Endotherapy; Over-the-scope clip; Suturing system;
   Endo-vacuum therapy; Endoscopic internal drainage; Self-expandable metal
   stent
ID ESOPHAGEAL ANASTOMOTIC LEAKS; VACUUM-ASSISTED CLOSURE; EXPANDABLE METAL
   STENT; SLEEVE GASTRECTOMY; INTERNAL DRAINAGE; MULTICENTER EXPERIENCE;
   CLINICAL-OUTCOMES; GASTRIC BYPASS; PLASTIC STENTS; THERAPY
AB Gastrointestinal leaks and fistulae are serious, potentially life threatening conditions that may occur with a wide variety of clinical presentations. Leaks are mostly related to post-operative anastomotic defects and are responsible for an important share of surgical morbidity and mortality. Chronic leaks and long standing post-operative collections may evolve in a fistula between two epithelialized structures. Endoscopy has earned a pivotal role in the management of gastrointestinal defects both as first line and as rescue treatment. Endotherapy is a minimally invasive, effective approach with lower morbidity and mortality compared to revisional surgery. Clips and luminal stents are the pioneer of gastrointestinal (GI) defect endotherapy, whereas innovative endoscopic closure devices and techniques, such as endoscopic internal drainage, suturing system and vacuum therapy, has broadened the indications of endoscopy for the management of GI wall defect. Although several endoscopic options are currently used, a standardized evidence-based algorithm for management of GI defect is not available. Successful management of gastrointestinal leaks and fistulae requires a tailored and multidisciplinary approach based on clinical presentation, defect features (size, location and onset time), local expertise and the availability of devices. In this review, we analyze different endoscopic approaches, which we selected on the basis of the available literature and our own experience. Then, we evaluate the overall efficacy and procedural-specific strengths and weaknesses of each approach.
C1 [Cereatti, Fabrizio; Grassia, Roberto; Drago, Andrea; Conti, Clara Benedetta] Cremona Hosp, Digest Endoscopy & Gastroenterol Unit, Viale Concordia 1, I-26100 Cremona, Italy.
   [Donatelli, Gianfranco] Hosp Prive Peupliers, Dept Intervent Endoscopy, Ramsay Sante, F-75013 Paris, France.
RP Cereatti, F (通讯作者)，Cremona Hosp, Digest Endoscopy & Gastroenterol Unit, Viale Concordia 1, I-26100 Cremona, Italy.
EM cereatti.fabrizio@gmail.com
OI Donatelli, Gianfranco/0000-0003-0645-1710; Conti, Clara
   Benedetta/0000-0001-9774-2374
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NR 108
TC 57
Z9 80
U1 1
U2 8
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD AUG 7
PY 2020
VL 26
IS 29
DI 10.3748/wjg.v26.i29.4198
PG 20
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA NE7OA
UT WOS:000562790400002
PM 32848329
OA Green Accepted, hybrid
DA 2026-07-24
ER
PT J
AU Costa, ML
   Achten, J
   Knight, R
   Png, ME
   Bruce, J
   Dutton, S
   Madan, J
   Vadher, K
   Dritsaki, M
   Masters, J
   Spoors, L
   Campolier, M
   Parsons, N
   Fernandez, M
   Jones, S
   Grant, R
   Nanchahal, J
AF Costa, Matthew L.
   Achten, Juul
   Knight, Ruth
   Png, May Ee
   Bruce, Julie
   Dutton, Susan
   Madan, Jason
   Vadher, Karan
   Dritsaki, Melina
   Masters, James
   Spoors, Louise
   Campolier, Marta
   Parsons, Nick
   Fernandez, Miguel
   Jones, Suzanne
   Grant, Richard
   Nanchahal, Jagdeep
CA WhiST Collaborators
TI Negative-pressure wound therapy compared with standard dressings
   following surgical treatment of major trauma to the lower limb: the
   WHiST RCT
SO HEALTH TECHNOLOGY ASSESSMENT
LA English
DT Article
ID TIBIAL PLAFOND; OPEN FRACTURE; HEALTH; DISABILITY; FIXATION; EQ-5D-5L;
   PATIENT; ADULTS; PAIN
AB Background: Major trauma is the leading cause of death in people aged < 45 years. Patients with major trauma usually have lower-limb fractures. Surgery to fix the fractures is complicated and the risk of infection may be as high as 27%. The type of dressing applied after surgery could potentially reduce the risk of infection.
   Objectives: To assess the deep surgical site infection rate, disability, quality of life, patient assessment of the surgical scar and resource use in patients with surgical incisions associated with fractures following major trauma to the lower limbs treated with incisional negative-pressure wound therapy versus standard dressings.
   Design: A pragmatic, multicentre, randomised controlled trial.
   Setting: Twenty-four specialist trauma hospitals representing the UK Major Trauma Network.
   Participants: A total of 1548 adult patients were randomised from September 2016 to April 2018. Exclusion criteria included presentation > 72 hours after injury and inability to complete questionnaires.
   Interventions: Incisional negative-pressure wound therapy (n = 785), in which a non-adherent absorbent dressing covered with a semipermeable membrane is connected to a pump to create a partial vacuum over the wound, versus standard dressings not involving negative pressure (n = 763). Trial participants and the treating surgeon could not be blinded to treatment allocation.
   Main outcome measures: Deep surgical site infection at 30 days was the primary outcome measure. Secondary outcomes were deep infection at 90 days, the results of the Disability Rating Index, health-related quality of life, the results of the Patient and Observer Scar Assessment Scale and resource use collected at 3 and 6 months post surgery.
   Results: A total of 98% of participants provided primary outcome data. There was no evidence of a difference in the rate of deep surgical site infection at 30 days. The infection rate was 6.7% (50/749) in the standard dressing group and 5.8% (45/770) in the incisional negative-pressure wound therapy group (intention-to-treat odds ratio 0.87; 95% confidence interval 0.57 to 1.33; p = 0.52). There was no difference in the deep surgical site infection rate at 90 days: 13.2% in the standard dressing group and 11.4% in the incisional negative-pressure wound therapy group (odds ratio 0.84, 95% confidence interval 0.59 to 1.19; p = 0.32). There was no difference between the two groups in disability, quality of life or scar appearance at 3 or 6 months. Incisional negative-pressure wound therapy did not reduce the cost of treatment and was associated with a low probability of cost-effectiveness.
   Limitations: Owing to the emergency nature of the surgery, we anticipated that some patients who were randomised would subsequently be unable or unwilling to participate. However, the majority of the patients (85%) agreed to participate. Therefore, participants were representative of the population with lower-limb fractures associated with major trauma.
   Conclusions: The findings of this study do not support the use of negative-pressure wound therapy in patients having surgery for major trauma to the lower limbs.
   Future work: Our work suggests that the use of incisional negative-pressure wound therapy dressings in other at-risk surgical wounds requires further investigation. Future research may also investigate different approaches to reduce postoperative infections, for example the use of topical antibiotic preparations in surgical wounds and the role of orthopaedic implants with antimicrobial coatings when fixing the associated fracture.
C1 [Costa, Matthew L.; Achten, Juul; Masters, James; Spoors, Louise; Campolier, Marta; Fernandez, Miguel; Nanchahal, Jagdeep] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
   [Knight, Ruth; Png, May Ee; Dutton, Susan; Vadher, Karan; Dritsaki, Melina] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Clin Trials Res Unit, Oxford, England.
   [Bruce, Julie; Madan, Jason] Univ Warwick, Warwick Med Sch, Clin Trials Unit, Coventry, W Midlands, England.
   [Parsons, Nick] Univ Warwick, Warwick Med Sch, Stat & Epidemiol Unit, Coventry, W Midlands, England.
C3 University of Oxford; University of Oxford; University of Warwick;
   University of Warwick
RP Costa, ML (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
EM matthew.costa@ndorms.ox.ac.uk
RI ; Masters, James/U-8764-2019; Achten, Juul/KUD-8515-2024; Bruce,
   Julie/G-7588-2014; Parsons, Nick/AAA-8713-2019; Png, May
   Ee/AAG-4902-2019
OI Madan, Jason/0000-0003-4316-1480; Masters, James/0000-0001-9663-8858;
   Achten, Juul/0000-0002-8857-5743; Costa, Matthew/0000-0003-3644-1388;
   Bruce, Julie/0000-0002-8462-7999; Parsons, Nick/0000-0001-9975-888X;
   Knight, Ruth/0000-0001-6810-2845; Nanchahal,
   Jagdeep/0000-0002-9579-9411; Png, May Ee/0000-0001-5876-9363; Campolier,
   Marta/0000-0002-7168-2534; Vadher, Karan/0000-0002-6287-5596
FU National Institute for Health Research Health Technology Assessment
   programme; National Institute for Health Research [14/199/14] Funding
   Source: researchfish
FX This project was funded by the National Institute for Health Research
   Health Technology Assessment programme and will be published in full in
   Health Technology Assessment; Vol. 24, No. 38. See the NIHR Journals
   Library for further project information.
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NR 62
TC 17
Z9 20
U1 0
U2 9
PU NIHR JOURNALS LIBRARY
PI SOUTHAMPTON
PA UNIV SOUTHAMPTON, EVALUATION, TRIALS & STUDIES COORDINATING CENTRE,
   ALPHA HOUSE, ENTERPRISE RD, SOUTHAMPTON, SO16 7NS, ENGLAND
SN 1366-5278
EI 2046-4924
J9 HEALTH TECHNOL ASSES
JI Health Technol. Assess.
PD AUG
PY 2020
VL 24
IS 38
BP I
EP +
DI 10.3310/hta24380
PG 108
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA NF0MJ
UT WOS:000562997400001
PM 32821038
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Bui, RD
   Lam, K
   Panchbhavi, VK
AF Bui, Roger D.
   Lam, Kenrick
   Panchbhavi, Vinod K.
TI Efficacy of a Urinary Bladder Matrix for Treating Wound Dehiscence With
   Hardware Exposure in a Patient With Rheumatoid Arthritis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE hardware exposure; infection; rheumatoid arthritis; urinary bladder
   matrix; wound dehiscence
ID INFECTIONS; SURGERY; THERAPY; FOOT; RISK
AB Objective. This case report explores an effective treatment modality in a medically complicated patient, with considerable wound dehiscence refractory to treatment with negative pressure wound therapy (NPWT). Case Report. A 35-year-old woman with a past medical history of hypothyroidism, osteoporosis, and rheumatoid arthritis treated with tumor necrosis factor (TNF) alpha inhibitors and disease-modifying antirheumatic drugs presented to the clinic following right great toe arthrodesis, metatarsal neck osteotomies, extensor tendon lengthening, and capsulotomy of the second, third, fourth, and fifth toes 2 weeks prior, with wound dehiscence of the right great toe and subsequent exposure of surgical hardware, complicated by infection. At the 2-week postop, a urinary bladder matrix was placed on the wound following failed NPWT, which was in place for io days. At the 3-month follow-up, the wound was closed and without any drainage. Patient reported a significant reduction in pain (visual analogue scale: 3) with adherence to weight-bearing restrictions. Conclusions. Wound healing was accomplished without removal of the exposed deep hardware in a patient with comorbidities and post-surgical wound dehiscence.
C1 [Bui, Roger D.; Lam, Kenrick; Panchbhavi, Vinod K.] Univ Texas Med Branch, Galveston, TX 77555 USA.
C3 University of Texas System; University of Texas Medical Branch Galveston
RP Bui, RD (通讯作者)，Univ Texas Med Branch, Sch Med, 3O1 Univ Blvd, Galveston, TX 77555 USA.
EM rdbui@utmb.edu
RI Panchbhavi, Vinod/AAN-1355-2021
CR Alvarez OM, 2017, WOUNDS, V29, P140
   Berthold E, 2013, ACTA ORTHOP, V84, P495, DOI 10.3109/17453674.2013.842431
   Bongartz T, 2006, JAMA-J AM MED ASSOC, V295, P2275, DOI 10.1001/jama.295.19.2275
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   Ishie S, 2015, MOD RHEUMATOL, V25, P367, DOI 10.3109/14397595.2014.966975
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   Kimmel Howard, 2010, J Am Col Certif Wound Spec, V2, P55, DOI 10.1016/j.jcws.2010.11.002
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   Listing J, 2005, ARTHRITIS RHEUM-US, V52, P3403, DOI 10.1002/art.21386
   Meaike JD, 2016, SEMIN PLAST SURG, V30, P73, DOI 10.1055/s-0036-1580728
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NR 16
TC 2
Z9 3
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2020
VL 32
IS 4
BP E27
EP E30
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NF1CR
UT WOS:000563040100001
PM 32335519
DA 2026-07-24
ER
PT J
AU Fernández, LG
   Matthews, MR
   Seal, L
AF Fernandez, Luis G.
   Matthews, Marc R.
   Seal, Lawton
TI Intraabdominal Lavage of Hypochlorous Acid: A New Paradigm for the
   Septic and Open Abdomen
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE hypochlorous acid; open abdomen; intraabdominal lavage; negative
   pressure wound therapy; temporary abdominal closure; instillation; acute
   wound
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; DAMAGE-CONTROL;
   CLINICAL RECOMMENDATIONS; ABDOMINAL SEPSIS; MANAGEMENT; INSTILLATION;
   IMPACT; GUIDELINES; MULTICENTER
AB Introduction. Management of the open abdomen (OA) has rapidly evolved over the last several decades due to the improved understanding of the underlying pathophysiolog of patients with an OA, adoption of damage control surgery, and the use of temporary abdominal closure has been (TAC) techniques for this patient population. The TAC utilizing negative pressure successful managing patients with an OA with improved time to closure. Recent studies have started to examine the use of TAC in conjunction with negative pressure wound therapy with instillation and dwell time (NPWTi-d) for the management of the OA Objective. This case series illustrates the capability, safety, and clinical effectiveness of TAC/NPWTi-d with hypochlorous acid (HOCI) solution. Materials and Methods. Three successfully treated cases describe the use of NPWTi-d using HOCI solution for the management of patients with a septic OA. Results. This initial experience suggests instillation of HOCI through the tubing set, in conjunction with the TAC device, is safe and easy to use. This technique decreased the need for more frequent OA lavages in the operating room (OR) after the index procedure, as well as the associated concomitant risks of transporting patients who are critically ill between the SICU and OR. No acute complications related to the TAC device with HOCI were noted. Conclusions. Based on the results of this study, the authors believe instillation through the TAC device may be the next evolution in the use of abdominal NPWT and programmed intermittent lavage of the peritoneal cavity represents an effective method in the care of patients with a septic OA.
C1 [Fernandez, Luis G.] Univ Texas Hlth Ctr Tyler, Tyler, TX USA.
   [Matthews, Marc R.] Maricopa Integrated Hlth Syst, Phoenix, AZ USA.
   [Seal, Lawton] Univ North Texas, Denton, TX 76203 USA.
C3 University of Texas System; University of Texas-Health Sciences Center
   at Tyler (UTHSCT); Maricopa County General Hospital; Maricopa Integrated
   Health System; University of North Texas System; University of North
   Texas Denton
RP Fernández, LG (通讯作者)，UT Hlth East Texas Phys Tyler, Surg, Dept Surg, 6801 Hollytree Cirde, Tyler, TX 75703 USA.
EM thebigkahuna115@gmail.com
RI FERNANDEZ, LUIS/O-7657-2019
OI FERNANDEZ, LUIS/0000-0002-2730-0199
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NR 67
TC 11
Z9 14
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2020
VL 32
IS 4
BP 107
EP 114
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NF1CR
UT WOS:000563040100004
PM 32155118
DA 2026-07-24
ER
PT J
AU Googe, B
   Davidson, JC
   Arnold, PB
   Medina, A
AF Googe, Benjamin
   Davidson, John Clayton
   Arnold, Peter B.
   Medina, Abelardo
TI Closed Incisional Negative Pressure Wound Therapy Sponge Width and
   Tension Off-Loading A Laboratory Model
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; surgical wound dehiscence; prevention &
   control; analysis of variance; biomechanical phenomena; wound healing;
   physiology; models; anatomic; closed incisional negative pressure wound
   therapy; incisional V; A; C
ID VACUUM-ASSISTED CLOSURE
AB Closed incisional negative pressure wound therapy (ciNPWT) has become commonplace in surgery. One mechanism ciNPWT may prevent incision site complications is by off-loading tension. This study aimed to find what width sponge using ciNPWT provides the most tension off-loading. A model was designed to test tension off-loading of a wound using ciNPWT. An incision was made in an anatomy model and closed with single stitch at the central axis. Force was applied tangentially using a force gauge at a steady rate until the wound dehisced at a peak force indicated by the 5-0 suture breaking. This was repeated 10 times for the following 4 trials: no ciNPWT and ciNPWT sponges cut a 3-, 6-, and 9-cm widths with 125 mm Hg of negative pressure. The mean peak force to dehisce the wound without ciNPWT was the lowest, 28.7 N. The mean force for the ciNPWT trials was 43.0, 38.7, and 36.4 N for V.A.C. sponges of 3, 6, and 9 cm in width, respectively. There was a statically significant difference among all the trials using one-way analysis of variance with Tukey posttest analysis with aPvalue of less than 0.0001. Closed incisional negative pressure wound therapy was shown to increase peak force required to dehisce an incision of up to 49.7% compared with closure without. There is an inverse relationship with sponge width and tension off-loading. The smaller the sponge, the more tension is off-loaded across the incision. Closed incisional negative pressure wound therapy with a 3-cm-wide sponge required the greatest peak force for dehiscence.
C1 [Googe, Benjamin; Arnold, Peter B.; Medina, Abelardo] Univ Mississippi, Div Plast & Reconstruct Surg, Med Ctr, Jackson, MS 39110 USA.
   [Davidson, John Clayton] Univ Mississippi, Sch Med, Jackson, MS 39110 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi; University of Mississippi Medical Center
RP Googe, B (通讯作者)，Univ Mississippi, Med Ctr, Div Plast Surg, 2500 N State St, Jackson, MS 39110 USA.
EM bgooge@umc.edu
RI Medina, Abelardo/AAG-7923-2021
CR Bonds AM, 2013, DIS COLON RECTUM, V56, P1403, DOI 10.1097/DCR.0b013e3182a39959
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NR 18
TC 8
Z9 9
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD SEP
PY 2020
VL 85
IS 3
BP 295
EP 298
DI 10.1097/SAP.0000000000002217
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NF8LY
UT WOS:000563545500019
PM 31923015
DA 2026-07-24
ER
PT J
AU Zhang, L
   Zhao, Y
   Lu, Y
   He, PP
   Zhang, P
   Lv, ZH
   Shen, YX
AF Zhang, Lei
   Zhao, Yao
   Lu, Yan
   He, Pingping
   Zhang, Peng
   Lv, Zhanhui
   Shen, Yixin
TI Effects of vacuum sealing drainage to improve the therapeutic effect in
   patients with orthopedic trauma and to reduce post-operative infection
   and lower-limb deep venous thrombosis
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE vacuum sealing drainage; orthopedic trauma; postoperative infection;
   lower-limb deep venous thrombosis
ID PRESSURE WOUND THERAPY
AB The present study investigated the effects of vacuum sealing drainage (VSD) to improve the therapeutic efficacy in patients with orthopedic trauma (OT) and reduce post-operative infection and lower-limb deep venous thrombosis (DVT) through a retrospective analysis. A total of 76 patients with OT treated at our hospital were selected for observation. The patients were divided into the control group (CG; n=37) and the experimental group (EG; n=39) according to the treatment administered. For patients in the CG, routine dressing changes were applied. Patients in the EG underwent VSD treatment. The dressing change frequency, time between the first and second operation, hospital stay, treatment efficacy, wound healing time, interleukin-6 (IL-6) serum level, tumor necrosis factor-alpha (TNF-alpha) serum level, incidence of post-operative infection and incidence of lower-limb DVT were compared between the two groups. The dressing change frequency in the EG was less than that in the CG. The time between the first and second operation and hospital stay were shorter in the EG than in the CG (P < 0.05). The total effective rate in the EG was 97.44%, which was higher than that in the CG (78.38%; P < 0.05). The wound healing time in the EG was 1.72 +/- 0.73 weeks and shorter than that in the CG (2.23 +/- 0.85 weeks; P < 0.05). With the progression of treatment, the serum IL-6 and TNF-alpha levels decreased in the two groups, but the levels in the EG were lower than those in the CG (P < 0.05). The incidence of post-operative infection and lower-limb venous thrombosis in the EG were 7.69 and 0.00%, respectively, and lower than those in the CG (27.03 and 13.01%, respectively; P < 0.05). In the treatment of OT, VSD may reduce the dressing change frequency, shorten the operation time and hospital stay, accelerate wound healing and reduce post-operative infection and lower-limb DVT. Thus, the VSD treatment method is worthy of promotion and implementation in clinic.
C1 [Zhang, Lei; Zhang, Peng; Shen, Yixin] Soochow Univ, Dept Orthopaed, Affiliated Hosp 2, 1055 Sanxiang Rd, Suzhou 215006, Jiangsu, Peoples R China.
   [Zhang, Lei; Lu, Yan; Lv, Zhanhui] Binzhou Med Univ, Dept Orthopaed, Binzhou Cent Hosp, Binzhou 251700, Shandong, Peoples R China.
   [Zhao, Yao] Shandong Univ, Dept Orthoped, Shandong Prov ENT Hosp, Jinan 250000, Shandong, Peoples R China.
   [He, Pingping] Binzhou Med Univ, Dept Clin Pharm, Binzhou Cent Hosp, Binzhou 251700, Shandong, Peoples R China.
C3 Soochow University - China; Shandong Medical & Pharmaceutical
   University; Shandong University; Shandong Medical & Pharmaceutical
   University
RP Shen, YX (通讯作者)，Soochow Univ, Dept Orthopaed, Affiliated Hosp 2, 1055 Sanxiang Rd, Suzhou 215006, Jiangsu, Peoples R China.
EM yyyishee@163.com
OI Zhao, Yao/0009-0008-2468-9910
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   Saku I, 2017, INT J SURG CASE REP, V37, P106, DOI 10.1016/j.ijscr.2017.06.027
   Shim HS, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/3629643
   Walker ME, 2018, J PLAST RECONSTR AES, V71, P438, DOI 10.1016/j.bjps.2017.11.013
   Webb LX, 2017, ORTHOP CLIN N AM, V48, P167, DOI 10.1016/j.ocl.2016.12.004
NR 25
TC 13
Z9 20
U1 0
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD SEP
PY 2020
VL 20
IS 3
BP 2305
EP 2310
DI 10.3892/etm.2020.8941
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA NG2VU
UT WOS:000563844300057
PM 32765709
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zwanenburg, PR
   Timmermans, FW
   Timmer, AS
   Middelkoop, E
   Tol, BT
   Lapid, O
   Obdeijn, MC
   Gans, SL
   Boermeester, MA
AF Zwanenburg, Pieter R.
   Timmermans, Floyd W.
   Timmer, Allard S.
   Middelkoop, Esther
   Tol, Berend T.
   Lapid, Oren
   Obdeijn, Miryam C.
   Gans, Sarah L.
   Boermeester, Marja A.
TI A systematic review evaluating the influence of incisional Negative
   Pressure Wound Therapy on scarring
SO WOUND REPAIR AND REGENERATION
LA English
DT Review
ID SURGICAL WOUNDS; MANAGEMENT; DEVICE; TRIAL
AB Pathological scars can result in functional impairment, disfigurement, a psychological burden, itch, and even chronic pain. We conducted a systematic review to investigate the influence of incisional Negative Pressure Wound Therapy (iNPWT) on scarring. PubMed, EMBASE and CINAHL were searched for preclinical and clinical comparative studies that investigated the influence of iNPWT on scarring-related outcomes. Individual studies were assessed using the OHAT Risk of Bias Rating Tool for Human and Animal studies. The body of evidence was rated using OHAT methodology. Six preclinical studies and nine clinical studies (377 patients) were identified. Preclinical studies suggested that iNPWT reduced lateral tension on incisions, increased wound strength, and reduced scar width upon histological assessment. Two clinical studies reported improved patient-reported scar satisfaction as measured with the PSAS (1 year after surgery), POSAS, and a VAS (both 42, 90, and 180 days after surgery). Five clinical studies reported improved observer-reported scar satisfaction as measured with the VSS, SBSES, OSAS, MSS, VAS, and POSAS (7, 15, 30, 42, 90, 180, and 365 days after surgery). Three clinical studies did not detect significant differences at any point in time (POSAS, VAS, and NRS). Because of imprecision concerns, a moderate level of evidence was identified using OHAT methodology. Preclinical as well as clinical evidence indicates a beneficial influence of iNPWT on scarring. Moderate level evidence indicates that iNPWT decreases scar width and improves patient and observer-reported scar satisfaction.
C1 [Zwanenburg, Pieter R.; Timmer, Allard S.; Tol, Berend T.; Gans, Sarah L.; Boermeester, Marja A.] Univ Amsterdam, Amsterdam Gastroenterol & Metab, Amsterdam Infect & Immun, Dept Surg,Amsterdam UMC, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands.
   [Timmermans, Floyd W.; Middelkoop, Esther] Vrije Univ Amsterdam, Dept Plast Reconstruct & Hand Surg, Amsterdam Movement Sci Res Inst, Amsterdam UMC, Amsterdam, Netherlands.
   [Middelkoop, Esther] Red Cross Hosp, Assoc Dutch Burn Ctr, Beverwijk, Netherlands.
   [Lapid, Oren; Obdeijn, Miryam C.] Univ Amsterdam, Amsterdam UMC, Dept Plast Reconstruct & Hand Surg, Amsterdam, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; University of
   Amsterdam; University of Amsterdam
RP Boermeester, MA (通讯作者)，Univ Amsterdam, Amsterdam Gastroenterol & Metab, Amsterdam Infect & Immun, Dept Surg,Amsterdam UMC, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands.
EM m.a.boermeester@amsterdamumc.nl
RI ; Middelkoop, Esther/M-3735-2014; Lapid, Oren/S-6331-2019
OI Boermeester, Marja/0000-0003-3890-8105; Middelkoop,
   Esther/0000-0001-8843-1080; Zwanenburg, Pieter/0000-0002-0301-2838;
   Lapid, Oren/0000-0001-8921-9866
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
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   Suh H, 2016, ANN PLAS SURG, V76, P717, DOI 10.1097/SAP.0000000000000231
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   Tanaydin V, 2018, AESTHET PLAST SURG, V42, P927, DOI 10.1007/s00266-018-1095-0
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   Zwanenburg PR, 2018, SURG INFECT, V19, P821, DOI 10.1089/sur.2018.212
NR 33
TC 16
Z9 22
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN
PY 2021
VL 29
IS 1
BP 8
EP 19
DI 10.1111/wrr.12858
EA AUG 2020
PG 12
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA PT3DV
UT WOS:000563905300001
PM 32789902
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Granger, S
   Fallon, J
   Hopkins, J
   Pullyblank, A
AF Granger, S.
   Fallon, J.
   Hopkins, J.
   Pullyblank, A.
TI An open and closed case: timing of closure following laparostomy
SO ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
LA English
DT Article
DE Laparostomy; Open abdomen; Negative pressure wound therapy; Closure;
   Timing
ID PRIMARY FASCIAL CLOSURE; OPEN ABDOMEN; TRAUMA PATIENTS; MANAGEMENT;
   OUTCOMES; HERNIA
AB INTRODUCTION Laparostomy is important in the management of patients with intra-abdominal gastrointestinal catastrophe or trauma. It carries significant risk and is resource intensive, both in terms of nursing and surgically. The main goal is to achieve prompt myofascial closure (MFC) in order to minimise morbidity and mortality. Early MFC was initially defined as within 2-3 weeks but there is growing evidence that this should be measured in days.
   METHODS Retrospective analysis was undertaken of laparostomy cases between 2016 and 2018 at an acute trust and trauma centre serving a population of 500,000. Indication, duration of open abdomen (OA), number of relook procedures and consultant presence were examined to see whether they affected MFC rates, morbidity and mortality.
   RESULTS Overall, 76 laparostomies were performed during the 3-year study period. The most common indication was peritonitis (68.4%). As duration of OA and number of relook procedures increased, the chances of MFC fell significantly. After day 1, MFC rates fell by 20% with each subsequent 24 hours. Leaving the abdomen open primarily at index procedure compared with performing laparostomy following a postoperative complication was associated with significantly higher MFC rates (92.6% vs 68.2%, (p=0.006). The mortality rate was 15.8%.
   CONCLUSIONS If the OA is not closed within five days or by the third relook procedure, then achieving MFC is unlikely. Alternative methods should be employed to close the abdomen rather than continuing to take the patient back to theatre for relook laparotomies while increasing the risk of morbidity and mortality. A proactive strategy to forming primary laparostomy at the index procedure has high closure rates.
C1 [Granger, S.; Fallon, J.; Hopkins, J.; Pullyblank, A.] North Bristol NHS Trust, Bristol, Avon, England.
C3 North Bristol NHS Trust
RP Granger, S (通讯作者)，North Bristol NHS Trust, Bristol, Avon, England.
EM s.granger@nhs.net
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NR 29
TC 13
Z9 17
U1 0
U2 1
PU ROYAL COLL SURGEONS ENGLAND
PI LONDON
PA 35-43 LINCOLN'S INN FIELDS, LONDON WC2A 3PN, ENGLAND
SN 0035-8843
EI 1478-7083
J9 ANN ROY COLL SURG
JI Ann. R. Coll. Surg. Engl.
PD SEP
PY 2020
VL 102
IS 7
BP 519
EP 524
DI 10.1308/rcsann.2020.0105
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NH9OI
UT WOS:000564990100019
PM 32538103
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Vallarino, N
   Devriendt, N
   Koenraadt, A
   Or, M
   Stock, E
   Floré, A
   de Rooster, H
AF Vallarino, N.
   Devriendt, N.
   Koenraadt, A.
   Or, M.
   Stock, E.
   Flore, A.
   de Rooster, H.
TI The effect of closed-incision negative pressure wound therapy on
   clinical and ultrasonographic seroma formation and wound healing
   following forequarter amputation in large dogs - a randomized pilot
   trial
SO VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SURGICAL WOUNDS; SKIN-GRAFTS; LAPAROTOMY;
   COMPLICATIONS; ARTHROPLASTY; DRESSINGS; DRAINS
AB This pilot study aimed at evaluating whether closed-incision negative pressure wound therapy (ciNPWT) has an effect on seroma formation and wound healing following forequarter amputation in dogs above 20 kg. Twelve client-owned dogs weighing more than 20 kg, presented for forequarter amputation, were randomly assigned after surgery into two groups (six ciNPWT and six controls with soft-padded bandage, both bandages applied for three days). A clinical and ultrasonographic control (newly developed scoring system) was performed at bandage removal (three days postoperatively) and ten days, postoperatively. A postoperative seroma was present in 4/6 dogs in the ciNPWT group and in 5/6 dogs in the control group. There were no apparent differences in the ultrasonographic scores or subcutis measurements at three versus ten days, postoperatively. The results of this pilot trial do not support expansion to a larger-scale study evaluating ciNPWT after forequarter amputation in dogs.
C1 [Vallarino, N.; Devriendt, N.; Koenraadt, A.; Or, M.; Flore, A.; de Rooster, H.] Univ Ghent, Fac Vet Med, Small Anim Dept, Salisburylaan 133, B-9820 Merelbeke, Belgium.
   [Stock, E.] Univ Ghent, Dept Med Imaging Domest Anim & Orthoped Small Ani, Fac Vet Med, Salisburylaan 133, B-9820 Merelbeke, Belgium.
   [Vallarino, N.] Vet Clin Vetopt, 190 Rue Claude Nicolas Ledoux, F-13290 Aix En Provence, France.
C3 Ghent University; Ghent University
RP Vallarino, N (通讯作者)，Univ Ghent, Fac Vet Med, Small Anim Dept, Salisburylaan 133, B-9820 Merelbeke, Belgium.; Vallarino, N (通讯作者)，Vet Clin Vetopt, 190 Rue Claude Nicolas Ledoux, F-13290 Aix En Provence, France.
EM vallarino.vet@gmail.com
RI Devriendt, Nausikaa/S-6629-2019; de Rooster, Hilde/AAX-9497-2020
OI Devriendt, Nausikaa/0000-0002-5070-8176; de Rooster,
   Hilde/0000-0001-8087-256X
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NR 48
TC 0
Z9 0
U1 0
U2 6
PU UNIV GHENT
PI GHENT
PA FACULTY VETERINARY MEDICINE, B-9000 GHENT, BELGIUM
SN 0303-9021
J9 VLAAMS DIERGEN TIJDS
JI Vlaams Diergeneeskd. Tijdschr.
PD JUL-AUG
PY 2020
VL 89
IS 4
BP 198
EP 208
DI 10.21825/vdt.v89i4.16577
PG 11
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA NI1GI
UT WOS:000565106000002
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Meyer, J
   Roos, E
   Abbassi, Z
   Toso, C
   Ris, F
   Buchs, NC
AF Meyer, Jeremy
   Roos, Elin
   Abbassi, Ziad
   Toso, Christian
   Ris, Frederic
   Buchs, Nicolas C.
TI The role of perineal application of prophylactic negative-pressure wound
   therapy for prevention of wound-related complications after
   abdomino-perineal resection: a systematic review
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Review
DE Abdomino-perineal amputation; Abdomino-perineal resection; Colorectal
   cancer; Rectal cancer; Infection; Perineal infection
ID RECTAL-CANCER; PELVIC FLOOR; RECONSTRUCTION; MANAGEMENT; EXCISION;
   CLOSURE
AB Background Closed perineal wounds often fail to heal by primary intention after abdomino-perineal resection (APR) and are often complicated by surgical site infection (SSI) and/or wound dehiscence. Recent evidence showed encouraging results of prophylactic negative-pressure wound therapy (pNPWT) for prevention of wound-related complications in surgery. Our objective was to gather and discuss the early existing literature regarding the use of pNPWT to prevent wound-related complications on perineal wounds after APR. Methods Medline, Embase, and Web of Science were searched for original publications and congress abstracts reporting the use of pNPWT after APR on closed perineal wounds. Results Seven publications were included for analysis. Two publications reported significantly lower incidence of SSI in pNPWT patients than in controls with a risk reduction of about 25-30%. Two other publications described similar incidences of SSI between the two groups of patients but described SSI in pNPWT patients to be less severe. One study reported significantly lower incidence of wound dehiscence in pNPWT patients than in controls. Conclusion The largest non-randomized studies investigating the effect of pNPWT on the prevention of wound-related complications after APR showed encouraging results in terms of reduction of SSI and wound dehiscence that deserve further investigation and confirmation.
C1 [Meyer, Jeremy; Abbassi, Ziad; Toso, Christian; Ris, Frederic; Buchs, Nicolas C.] Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Roos, Elin] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
C3 University of Geneva; Karolinska Institutet
RP Meyer, J (通讯作者)，Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM jeremy.meyer@hcuge.ch
RI Toso, Christian/E-7785-2018; Meyer, Jeremy/AAP-3367-2020; Abbassi,
   Ziad/HZL-6239-2023; Ris, Frederic/H-7030-2019
OI Toso, Christian/0000-0003-1652-4522; Meyer, Jeremy/0000-0003-3381-9146;
   Abbassi, Ziad/0000-0002-4130-5084; Ris, Frederic/0000-0001-7421-6101
FU University of Geneva
FX Open access funding provided by University of Geneva.
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NR 20
TC 18
Z9 21
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD JAN
PY 2021
VL 36
IS 1
BP 19
EP 26
DI 10.1007/s00384-020-03732-6
EA SEP 2020
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA PO1YK
UT WOS:000566084400001
PM 32886194
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Schlueer, AB
   Schwieger-Briel, A
   Theiler, M
   Neuhaus, K
   Schiestl, C
   Weibel, L
AF Schlueer, Anna-Barbara
   Schwieger-Briel, Agnes
   Theiler, Martin
   Neuhaus, Kathrin
   Schiestl, Clemens
   Weibel, Lisa
TI Negative pressure wound treatment in a neonate with epidermolysis
   bullosa simplex severe generalized: A case report
SO PEDIATRIC DERMATOLOGY
LA English
DT Article
DE epidermolysis bullosa; negative pressure wound treatment; vacuum
   assisted closure
ID THERAPY; MANAGEMENT
AB Negative pressure wound treatment (NPWT) is very useful for the treatment of chronic or deep wounds and in the setting of skin grafting. Due to the need for adhesive dressings, this treatment is rarely attempted in patients with skin fragility secondary to hereditary epidermolysis bullosa (EB). We present a neonate with EB simplex, severe generalized in a critical clinical state where NPWT was successfully applied and describe the measures taken to avoid any further skin damage. This case is of clinical importance to physicians and health care staff treating patients with this rare disease where additional therapeutic measures for the treatment of chronic wounds are scarce.
C1 [Schlueer, Anna-Barbara; Schwieger-Briel, Agnes; Theiler, Martin; Weibel, Lisa] Univ Childrens Hosp Zurich, Dept Pediat Dermatol, Pediat Skin Ctr, Zurich, Switzerland.
   [Schlueer, Anna-Barbara] Univ Childrens Hosp Zurich, Dept Nursing Sci, Zurich, Switzerland.
   [Schlueer, Anna-Barbara; Schwieger-Briel, Agnes; Theiler, Martin; Neuhaus, Kathrin; Schiestl, Clemens; Weibel, Lisa] Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland.
   [Neuhaus, Kathrin; Schiestl, Clemens] Univ Childrens Hosp Zurich, Pediat Skin Ctr, Dept Plast & Reconstruct Surg, Zurich, Switzerland.
C3 University Children's Hospital Zurich; University Children's Hospital
   Zurich; University Children's Hospital Zurich; University Children's
   Hospital Zurich
RP Schlueer, AB (通讯作者)，Univ Childrens Hosp, Dept Pediat Dermatol, Pediat Skin Ctr, Steinwiesstr 75, CH-8032 Zurich, Switzerland.
EM Agnes.Schwieger@kispi.uzh.ch
OI Schwieger-Briel, Agnes/0000-0001-7679-3981; Theiler,
   Martin/0000-0001-7160-3958; Weibel, Lisa/0000-0002-8696-8164; Neuhaus,
   Kathrin/0000-0003-2438-1779; Schlüer, Anna-Barbara/0000-0003-1046-3650
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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NR 14
TC 1
Z9 2
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-8046
EI 1525-1470
J9 PEDIATR DERMATOL
JI Pediatr. Dermatol.
PD NOV
PY 2020
VL 37
IS 6
BP 1218
EP 1220
DI 10.1111/pde.14335
EA SEP 2020
PG 3
WC Dermatology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Pediatrics
GA PB7HP
UT WOS:000566267300001
PM 32892402
DA 2026-07-24
ER
PT J
AU Santosa, KB
   Keane, AM
   Keller, M
   Olsen, MA
   Sears, ED
   Snyder-Warwick, AK
AF Santosa, Katherine B.
   Keane, Alexandra M.
   Keller, Matt
   Olsen, Margaret A.
   Sears, Erika D.
   Snyder-Warwick, Alison K.
TI Inpatient Versus Outpatient Management of Negative Pressure Wound
   Therapy in Pediatric Patients
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Negative pressure wound therapy; Vacuum-assisted closure; Infants;
   Children; Inpatient; Outpatient
ID VACUUM-ASSISTED CLOSURE; VAC(R) THERAPY; CHILDREN; COST; CARE;
   EXPERIENCE; POPULATION; INFANTS; NPWT; FOAM
AB Background: Negative pressure wound therapy (NPWT) is commonly used to manage complex wounds in the pediatric population. With recently developed portable NPWT devices, providers have the opportunity to transition NPWT to the outpatient setting. However, there are no studies describing outpatient NPWT in pediatric patients. Therefore, the purpose of our study was to leverage a population-level analysis to advance our current knowledge about outpatient NPWT use in pediatric patients.
   Materials and methods: We analyzed the Truven Health Analytics MarketScan Commercial Claims Database from 2006 to 2014 to identify children treated with NPWT. We compared patient characteristics, indications, complications before and after NPWT, health care utilization within 30 d of NPWT initiation, and health care cost profile of patients treated with NPWT primarily as outpatients versus inpatients. Outpatient NPWT was defined as patients with 50% of NPWT coded during an inpatient hospitalization, whereas inpatient NPWT was defined as patients with 50% of NPWT.
   Results: We identified 3184 patients (1621 inpatients and 1563 outpatients) aged 0-17 y, who were treated with NPWT from 2006 to 2014. Outpatient NPWT was implemented across multiple ages, comorbidities, and indications, with a low complication rate (2.4%). After controlling for hematologic comorbidity and indications, outpatient NPWT was associated with lower risk of complications (odds ratio: 0.57, 95% confidence interval 0.38-0.86) and lower median total costs ($5602.03) compared with inpatient ($15,233.21) therapy.
   Conclusions: Outpatient NPWT management in pediatric patients was associated with low complication rates. Additional studies are necessary to determine the most overall costeffective treatment setting for NPWT in the pediatric population. (c) 2020 Elsevier Inc. All rights reserved.
C1 [Santosa, Katherine B.; Keane, Alexandra M.; Snyder-Warwick, Alison K.] Washington Univ, Dept Surg, Div Plast & Reconstruct Surg, St Louis, MO 63110 USA.
   [Santosa, Katherine B.; Sears, Erika D.] Univ Michigan, Dept Surg, Sect Plast Surg, Ann Arbor, MI 48109 USA.
   [Keller, Matt; Olsen, Margaret A.] Washington Univ, Dept Med, Div Infect Dis, St Louis, MO USA.
   [Olsen, Margaret A.] Washington Univ, Dept Surg, Div Publ Hlth Sci, St Louis, MO 63110 USA.
   [Sears, Erika D.] VA Ann Arbor Healthcare Syst, Ctr Clin Management Res, Ann Arbor, MI USA.
C3 Washington University (WUSTL); University of Michigan System; University
   of Michigan; Washington University (WUSTL); Washington University
   (WUSTL); US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Ann Arbor Healthcare System
RP Snyder-Warwick, AK (通讯作者)，Washington Univ, Sch Med, Dept Surg, 660 S Euclid Ave Campus Box 8238, St Louis, MO 63110 USA.
EM snydera@wustl.edu
FU Washington University Institute of Clinical and Translational Sciences
   grant from National Center for Advancing Translational Sciences (NCATS)
   of the National Institutes of Health (NIH) [UL1TR000448]; National
   Institute of Neurological Disorders and Stroke [F32NS098561,
   K08NS096232]; Center for Administrative Data Research; Washington
   University Institute of Clinical and Translational Sciences from
   National Center for Advancing Translational Sciences of the NIH
   [UL1TR002345]; National Cancer Institute at the NIH; Agency for
   Healthcare Research and Quality [R24 HS19455]; National Cancer Institute
   at the NIH [KM1CA156708]; National Center for Advancing Translational
   Sciences [UL1TR002345] Funding Source: NIH RePORTER
FX Research reported in this publication was supported by the Washington
   University Institute of Clinical and Translational Sciences grant
   UL1TR000448 from the National Center for Advancing Translational
   Sciences (NCATS) of the National Institutes of Health (NIH) and by the
   National Institute of Neurological Disorders and Stroke under award
   numbers F32NS098561 (to K.B.S.) and K08NS096232 (to A.K.S.W.).In
   addition, the work was supported by the Center for Administrative Data
   Research, which is supported in part by the Washington University
   Institute of Clinical and Translational Sciences grant UL1TR002345 from
   the National Center for Advancing Translational Sciences of the NIH,
   grant number R24 HS19455 through the Agency for Healthcare Research and
   Quality, and grant number KM1CA156708 through the National Cancer
   Institute at the NIH.
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NR 50
TC 7
Z9 9
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD OCT
PY 2020
VL 254
BP 197
EP 205
DI 10.1016/j.jss.2020.04.025
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NK5PD
UT WOS:000566783600028
PM 32450421
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Oradan, A
   Muntean, M
AF Oradan, Alex
   Muntean, Maximilian
TI The Use of Negative Pressure Wound Therapy in the Management of Parotid
   Sialocele: A Case Report
SO LARYNGOSCOPE
LA English
DT Article
DE Sialocele; parotid gland; negative pressure wound therapy; sentinel
   lymph node biopsy
AB Parotid sialocele is an accumulation of saliva inside a subcutaneous cavity, usually as a result of trauma or iatrogenic injury of the parotid gland or duct, which can progress to other complications if left untreated. Numerous treatment options have been described before, but there is currently no evidence based consensus. We present a case of a patient treated for sialocele with the use of negative pressure wound therapy.Laryngoscope, 2020
C1 [Oradan, Alex; Muntean, Maximilian] Univ Med & Pharm Iuliu Hatieganu, Dept Plast Surg, Prof Dr I Chiricuta Inst Oncol, Str Republ 34-6, Cluj Napoca 400015, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Oncology Institute
   Prof. Dr. Ion Chiricuta
RP Oradan, A (通讯作者)，Univ Med & Pharm Iuliu Hatieganu, Dept Plast Surg, Prof Dr I Chiricuta Inst Oncol, Str Republ 34-6, Cluj Napoca 400015, Romania.
EM alex.oradan@yahoo.com
RI Muntean, Maximilian/HJP-8255-2023; Orădan, Alex/LJL-5044-2024
OI Muntean, Maximilian/0000-0003-0709-8779; Orădan,
   Alex/0000-0001-5911-983X
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Ashkenazi I, 2017, SURG J-NY, V3, DOI 10.1055/s-0037-1599273
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   Nagi R, 2016, J DIAGN RES, V10, P4
NR 5
TC 2
Z9 3
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD APR
PY 2021
VL 131
IS 4
BP E1094
EP E1095
DI 10.1002/lary.29078
EA SEP 2020
PG 2
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA QU0KJ
UT WOS:000566834300001
PM 32898314
DA 2026-07-24
ER
PT J
AU Eceviz, E
   Cevik, HB
AF Eceviz, Engin
   Cevik, Huseyin Bilgehan
TI Shoelace Technique Plus Negative-Pressure Wound Therapy Closure in
   Fasciotomy Wounds
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE fasciotomy; wound closure; dermatotraction; vessel-loop suture
   technique; negative-pressure wound therapy
ID VACUUM-ASSISTED CLOSURE
AB BACKGROUND Fasciotomy incision closure is often performed with skin grafts that can lead to cosmetic and functional complications after surgical intervention. Because fasciotomy incisions do not result in skin loss, the authors hypothesized that better closure can be achieved by reducing tissue edema with negative-pressure wound therapy (NPWT) and reducing stress on the skin with the shoelace surgical technique. METHODS This 1-year prospective study included eight patients with acute compartment syndrome after extremity fractures and/or blunt injuries. Patients were treated with fasciotomies closed with the shoelace technique and NPWT for wound margin approximation. The NPWT device was changed every second day; the shoelace traction tension was tightened at the same time. MAIN RESULTS The mean time from fasciotomy to wound closure was 11.8 days (range, 5-30 days). There was no need for a skin graft or flap in any patient. CONCLUSIONS The shoelace technique plus NPWT may be successful in closing skin fasciotomies after acute compartment syndrome without causing additional morbidity.
C1 [Eceviz, Engin] Univ Hlth Sci, Kartal Dr Lutfi Kirdar Res & Training Hosp, Dept Orthopaed & Traumatol, Istanbul, Turkey.
   [Cevik, Huseyin Bilgehan] Univ Hlth Sci, Diskapi Yildirim Beyazit Training & Res Hosp, Dept Orthopaed & Traumatol, Ankara, Turkey.
C3 University of Health Sciences Turkey; Istanbul Kartal Dr Lutfi Kirdar
   Training & Research Hospital; University of Health Sciences Turkey;
   Diskapi Yildirim Beyazit Training & Research Hospital
RP Eceviz, E (通讯作者)，Univ Hlth Sci, Kartal Dr Lutfi Kirdar Res & Training Hosp, Dept Orthopaed & Traumatol, Istanbul, Turkey.
RI eceviz, engin/N-3329-2014; cevik, bilgehan/T-3713-2019
OI eceviz, engin/0000-0003-2453-0869; 
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NR 16
TC 7
Z9 12
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD SEP
PY 2020
VL 33
IS 9
BP 497
EP 500
DI 10.1097/01.ASW.0000672492.38463.58
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA NK6VI
UT WOS:000566872300008
PM 32694300
DA 2026-07-24
ER
PT J
AU Song, F
   Liu, ZZ
AF Song, Feng
   Liu, Zhenzhong
TI Bilateral-pectoral major muscle advancement flap combined with
   vacuum-assisted closure therapy for the treatment of deep sternal wound
   infections after cardiac surgery
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Cardiac surgery; Deep sternal wound infections; Bilateral-pectoral major
   muscle advancement flap; Vacuum-assisted closure therapy
ID RISK-FACTORS; RECONSTRUCTION
AB Objectives The median sternotomy is the most common surgical approach for cardiac surgery. Deep sternal wound infection is a fatal complication after median sternotomy. The aim of this study was to evaluate the therapeutic effect of Bilateral-pectoral major muscle advancement flap combined with Vacuum-assisted closure therapy on rehabilitation for the treatment of deep sternal wound infection after cardiac surgery. Methods Between January 2016 to January 2018, 21 patients (10 males, 11 females) with deep sternal wound infection after cardiac surgery underwent Bilateral-pectoral major muscle advancement flap combined with Vacuum-assisted closure therapy. These patients were followed-up 12 months postoperative. The patient characteristics, duration of vacuum-assisted closure therapy, the mean hospital stay, postoperative complications, long-term survival of patients were retrospectively analyzed. Results Most patients undergone 1-3 times vacuum-assisted closure treatment sessions before closure. All patients were cured to discharge, the mean hospital stay was 21.1 days. Most patients' healing wounds were first-stage healing, only one patient's wound was second-stage healing, none was third-stage healing. One patient developed pulmonary infection and respiratory failure during the 12-month follow-up. None of the patients died during follow-up. Conclusions Bilateral-pectoral major muscle advancement flap combined with Vacuum-assisted closure therapy for the treatment of deep sternal wound infections after cardiac surgery can shorten the hospital stays and few complications. However, this is a retrospective case series presentation with no comparison group, the number of inferences is limited, so further large-scale controlled studies are needed.
C1 [Song, Feng; Liu, Zhenzhong] Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Plast Surg, 247 Beiyuan St, Jinan 250000, Shandong, Peoples R China.
C3 Shandong University
RP Liu, ZZ (通讯作者)，Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Plast Surg, 247 Beiyuan St, Jinan 250000, Shandong, Peoples R China.
EM drliuzhenzhong@163.com
CR Erdmann D, 2000, CHIRURG, V71, P1156, DOI 10.1007/s001040051194
   Floros P, 2011, HEART LUNG CIRC, V20, P712, DOI 10.1016/j.hlc.2011.08.001
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NR 12
TC 7
Z9 11
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD AUG 27
PY 2020
VL 15
IS 1
AR 227
DI 10.1186/s13019-020-01264-2
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA NK7FP
UT WOS:000566899000001
PM 32854735
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tang, JJ
   Tao, GL
   Liu, YK
   Ma, X
   Aobuliaximu, Y
   Lu, SL
AF Tang, JiaJun
   Tao, Guilu
   Liu, Yingkai
   Ma, Xian
   Aobuliaximu, Yakupu
   Lu, Shuliang
TI CO2Laser Debridement and Negative Pressure Wound Therapy With
   Endoscopic Support for Treatment of Sinus Wound at the Ischial
   Tuberosity: Case Report
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE CO(2)laser; negative ressure wound therapy; endoscopy; sinus wound;
   ischial tuberosity
AB The sinus tract of the ischial tuberosity is often caused by pressure injury. It has the characteristics of difficult treatment and high cost, which increases the anxiety of patients and reduces the quality of life of patients. This case report is to describe an effective method to treat sinus wound at the ischial tuberosity. A 53-year-old male suffered pressure ulcer with sinus wound at the left ischial tuberosity due to inadequate walking and sedentary activity. On the basis of pressure relief and immobilization, the patient was treated with CO(2)laser debridement and negative pressure wound therapy under endoscope support 3 times, the deep of the sinus wound was completely closed, and then the residual superficial wound was treated by skin grafting. Follow-up of 1 year after healing showed no recurrence of wound.
C1 [Tang, JiaJun; Tao, Guilu; Liu, Yingkai; Ma, Xian; Aobuliaximu, Yakupu; Lu, Shuliang] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University
RP Lu, SL (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Wound Healing Ctr, Sch Med, Shanghai 200025, Peoples R China.
EM 13901738685@139.com
RI Tang, JiaJun/J-1320-2014
CR Brienza D, 2010, J AM GERIATR SOC, V58, P2308, DOI 10.1111/j.1532-5415.2010.03168.x
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NR 15
TC 2
Z9 2
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2022
VL 21
IS 3
BP 337
EP 341
AR 1534734620953674
DI 10.1177/1534734620953674
EA SEP 2020
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 3B8DC
UT WOS:000566911200001
PM 32883117
DA 2026-07-24
ER
PT J
AU Chattinnakorn, S
   Suwajo, P
   Meevassana, J
   Nilprapha, K
   Pungrasmi, P
   Promniyom, P
   Iamphongsai, S
   Jindarak, S
   Angspatt, A
AF Chattinnakorn, Suphot
   Suwajo, Poonpissamai
   Meevassana, Jiraroch
   Nilprapha, Kasama
   Pungrasmi, Pornthep
   Promniyom, Pasu
   Iamphongsai, Seree
   Jindarak, Sirachai
   Angspatt, Apichai
TI The Effect of Cold Water on Pain Evaluation During Negative Pressure
   Wound Therapy Dressing Changes: A Prospective, Randomized Controlled
   Study
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE negative pressure wound therapy; NPWT; pain; wound dressing
ID VACUUM-ASSISTED CLOSURE; SUBSTANCE-P; INJURY; LEVEL
AB Negative pressure wound therapy (NPWT) is a technique using vacuum dressing to promote wound healing in complicated wound. However, for many patients, the application and removal of the NPWT is source of procedural pain. The authors hypothesized that administering cold sterile water into the NPWT sponge would decrease pain during dressing changes. A prospective randomized controlled study was conducted on 27 patients who were undergoing 81 NPWT wound dressing changes (n = 81) at a single institution between October 2016 and September 2017. Each patient had 3 NPWT dressing changes. Cold sterile water (5.74 degrees C), room temperature sterile water (26.89 degrees C), and nothing were randomized and administered in the NPWT tubing into the sponge 10 minutes before changing the dressing in each and every procedure. Pain scores were assessed using a 0 to 10 numeric pain scale. Patients administered with cold water reported less pain than those administered with room temperature sterile water during the dressing change (4 vs 5.67;P< .003), and much less pain than those with nothing instilled before dressing change (4 vs 6.59;P< .001). There is no statistically significant difference in pain score between using the room temperature sterile water group and the control group that instilled nothing (5.67 vs 6.59;P= .065). This study has shown that cold water administered through the suction tubing before the dressing change had a better reduction in pain score than using room temperature sterile water and the control group.
C1 [Chattinnakorn, Suphot; Suwajo, Poonpissamai; Meevassana, Jiraroch; Nilprapha, Kasama; Pungrasmi, Pornthep; Promniyom, Pasu; Iamphongsai, Seree; Jindarak, Sirachai; Angspatt, Apichai] Chulalongkorn Univ, Bangkok, Thailand.
C3 Chulalongkorn University
RP Angspatt, A (通讯作者)，Chulalongkorn Univ, Div Plast & Reconstruct Surg, Dept Surg, Fac Med, Rama 4 Rd, Bangkok 10330, Thailand.
EM aangspatt@hotmail.com
RI ; Suwajo, Poonpissamai/GOK-1291-2022
OI meevassana, jiraroch/0000-0001-8915-2999; 
CR Banwell P E, 2003, J Wound Care, V12, P22
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NR 27
TC 3
Z9 3
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2022
VL 21
IS 4
BP 432
EP 435
AR 1534734620950177
DI 10.1177/1534734620950177
EA AUG 2020
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 6H4QA
UT WOS:000567358800001
PM 32865057
DA 2026-07-24
ER
PT J
AU Frear, CC
   Cuttle, L
   McPhail, SM
   Chatfield, MD
   Kimble, RM
   Griffin, BR
AF Frear, C. C.
   Cuttle, L.
   McPhail, S. M.
   Chatfield, M. D.
   Kimble, R. M.
   Griffin, B. R.
TI Randomized clinical trial of negative pressure wound therapy as an
   adjunctive treatment for small-area thermal burns in children
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT 43rd Annual Scientific Meeting of the
   Australian-and-New-Zealand-Burn-Association
CY OCT, 2019
CL Hobart, AUSTRALIA
SP Australian & New Zealand Burn Assoc
ID PARTIAL-THICKNESS BURNS; SUBATMOSPHERIC PRESSURE; PEDIATRIC BURNS;
   ASSESSMENT SCALE; HEALING TIME; PROGRESSION; EPIDEMIOLOGY; MANAGEMENT;
   INFANTS; PROFILE
AB Background The efficacy of negative pressure wound therapy (NPWT) in the acute management of burns remains unclear. The purpose of this trial was to compare standard Acticoat (TM) and Mepitel (TM) dressings with combined Acticoat (TM), Mepitel (TM) and continuous NPWT to determine the effect of adjunctive NPWT on re-epithelialization in paediatric burns. Methods This two-arm, single-centre RCT recruited children with acute thermal burns covering less than 5 per cent of their total body surface area. The primary outcome was time to re-epithelialization. Blinded assessments were performed using photographs captured every 3-5 days until discharge. Secondary measures included pain, itch, grafting, perfusion and scar management referrals. Results Some 114 patients were randomized. Median time to re-epithelialization was 8 (i.q.r. 7-11) days in the NPWT group and 10 (8-14) days in the control group. In a multivariable model, NPWT decreased the expected time to wound closure by 22 (95 per cent c.i. 7 to 34) per cent (P = 0 center dot 005). The risk of referral to scar management was reduced by 60 (18 to 81) per cent (P = 0 center dot 013). Four participants in the control group and one in the NPWT group underwent grafting. There were no statistically significant differences between groups in pain, itch or laser Doppler measures of perfusion. Adverse events were rare and minor, although NPWT carried a moderate treatment burden, with ten patients discontinuing early. Conclusion Adjunctive NPWT hastened re-epithelialization in small-area burn injuries in children, but had a greater treatment burden than standard dressings alone. Registration number: ACTRN12618000256279 ( ).
C1 [Frear, C. C.; Cuttle, L.; Kimble, R. M.; Griffin, B. R.] Ctr Childrens Burns & Trauma Res, South Brisbane, Qld, Australia.
   [Kimble, R. M.] Queensland Childrens Hosp, South Brisbane, Qld, Australia.
   [Frear, C. C.; Chatfield, M. D.; Kimble, R. M.] Univ Queensland, Fac Med, Herston, Qld, Australia.
   [Cuttle, L.] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld, Australia.
   [McPhail, S. M.] Queensland Univ Technol, Australian Ctr Hlth Serv Innovat, Brisbane, Qld, Australia.
   [McPhail, S. M.] Queensland Univ Technol, Sch Publ Hlth & Social Work, Ctr Healthcare Transformat, Brisbane, Qld, Australia.
   [Griffin, B. R.] Queensland Univ Technol, Fac Hlth, Sch Nursing, Brisbane, Qld, Australia.
   [McPhail, S. M.] Metro South Hlth, Clin Informat Directorate, Brisbane, Qld, Australia.
C3 Childrens Health Queensland Hospital & Health Service; Queensland
   Childrens Hospital; University of Queensland; Queensland University of
   Technology (QUT); Queensland University of Technology (QUT); Queensland
   University of Technology (QUT); Queensland University of Technology
   (QUT)
RP Frear, CC (通讯作者)，Univ Queensland, Childrens Hlth Res Ctr, Ctr Childrens Burns & Trauma Res, Level 7,62 Graham St, South Brisbane, Qld 4101, Australia.
EM cody.frear@uqconnect.edu.au
RI ; Cuttle, Leila/C-5223-2008; Chatfield, Mark/N-2278-2013; Griffin,
   Bronwyn/AEB-6299-2022; Kimble, Roy/B-4160-2011; McPhail,
   Steven/JMR-2141-2023
OI Frear, Cody/0000-0002-6011-2472; Cuttle, Leila/0000-0002-2282-4815;
   Chatfield, Mark/0000-0002-0004-6274; Griffin,
   Bronwyn/0000-0002-6182-9125; McPhail, Steven/0000-0002-1463-662X
FU Australian Government Research Training Scholarship; Smith Nephew;
   Australian Government, National Health and Medical Research Council
   [APP1130862]
FX The authors acknowledge the children, families and clinicians who
   participated in the SONATA in C trial. They thank A. Bairagi, C.
   McMillan, B. Meikle and R. Walker for their contribution to the blinded
   reviews, and A. Bernard and F. Zahir for statistical input. Funding for
   the study was provided by an Australian Government Research Training
   Scholarship and a research grant from Smith & Nephew to the Queensland
   University of Technology. L.C. acknowledges Fellowship funding from the
   Australian Government, National Health and Medical Research Council
   (APP1130862). Smith & Nephew's involvement in the research was limited
   to its financial support. The funders had no role in the study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 47
TC 30
Z9 35
U1 3
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD DEC
PY 2020
VL 107
IS 13
BP 1741
EP 1750
DI 10.1002/bjs.11993
EA SEP 2020
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA OP9VK
UT WOS:000568883400001
PM 32926410
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Zwanenburg, PR
   Tol, BT
   Obdeijn, MC
   Lapid, O
   Gans, SL
   Boermeester, MA
AF Zwanenburg, Pieter R.
   Tol, Berend T.
   Obdeijn, Miryam C.
   Lapid, Oren
   Gans, Sarah L.
   Boermeester, Marja A.
TI Meta-analysis, Meta-regression, and GRADE Assessment of Randomized and
   Nonrandomized Studies of Incisional Negative Pressure Wound Therapy
   Versus Control Dressings for the Prevention of Postoperative Wound
   Complications
SO ANNALS OF SURGERY
LA English
DT Article
DE hematoma; incision; necrosis; negative pressure wound therapy;
   prevention; seroma; surgical site infection; surgical wound; wound care;
   wound dehiscence
ID SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED CLOSURE; HIGH-RISK PATIENTS;
   MAJOR MUSCLE FLAP; VASCULAR-SURGERY; MANAGEMENT-SYSTEM; OBESE-PATIENTS;
   LAPAROTOMY INCISIONS; CESAREAN DELIVERY; CLOSED INCISIONS
AB Objective: The aim of this study was to evaluate the efficacy of iNPWT for the prevention of postoperative wound complications such as SSI. Summary of Background Data: The 2016 WHO recommendation on the use of iNPWT for the prevention of SSI is based on low-level evidence, and many trials have been published since. Preclinical evidence suggests that iNPWT may also prevent wound dehiscence, skin necrosis, seroma, and hematoma. Methods: PubMed, EMBASE, CINAHL, and CENTRAL were searched for randomized and nonrandomized studies that compared iNPWT with control dressings. The evidence was assessed using the Cochrane Risk of Bias Tool, the Newcastle-Ottawa scale, and GRADE. Meta-analyses were performed using random-effects models. Results: High level evidence indicated that iNPWT reduced SSI [28 RCTs, n = 4398, relative risk (RR) 0.61, 95% confidence interval [CI]: 0.49-0.76,P< 0.0001,I-2= 27%] with a number needed to treat of 19. Low level evidence indicated that iNPWT reduced wound dehiscence (16 RCTs, n = 3058, RR 0.78, 95% CI: 0.64-0.94). Very low-level evidence indicated that iNPWT also reduced skin necrosis (RR 0.49, 95% CI: 0.33-0.74), seroma (RR 0.43, 95% CI: 0.32-0.59), and length of stay (pooled mean difference -2.01, 95% CI: -2.99 to 1.14). Conclusions: High-level evidence indicates that incisional iNPWT reduces the risk of SSI with limited heterogeneity. Low to very low-level evidence indicates that iNPWT also reduces the risk of wound dehiscence, skin necrosis, and seroma.
C1 [Zwanenburg, Pieter R.; Tol, Berend T.; Gans, Sarah L.; Boermeester, Marja A.] Univ Amsterdam, Dept Surg Amsterdam Gastroenterol & Metab, Amsterdam Infect & Immun, Amsterdam UMC, Amsterdam, Netherlands.
   [Obdeijn, Miryam C.; Lapid, Oren] Univ Amsterdam, Dept Plast Reconstruct & Hand Surg, Amsterdam UMC, Amsterdam, Netherlands.
C3 University of Amsterdam; University of Amsterdam
RP Boermeester, MA (通讯作者)，Univ Amsterdam, Dept Surg Amsterdam Gastroenterol & Metab, Amsterdam Infect & Immun, Amsterdam UMC, Amsterdam, Netherlands.
EM m.a.boermeester@amc.nl
RI ; Lapid, Oren/S-6331-2019
OI Boermeester, Marja/0000-0003-3890-8105; Lapid, Oren/0000-0001-8921-9866
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NR 141
TC 56
Z9 58
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JUL
PY 2020
VL 272
IS 1
BP 81
EP 91
DI 10.1097/SLA.0000000000003644
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NN6KR
UT WOS:000568895500030
PM 31592899
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Quercia, V
   Saccone, G
   Raffone, A
   Travaglino, A
   Favale, M
   D'Alessandro, P
   Arduino, B
   Carbone, IF
   Insabato, L
   Ribuffo, D
   Zullo, F
AF Quercia, Vittorio
   Saccone, Gabriele
   Raffone, Antonio
   Travaglino, Antonio
   Favale, Mariano
   D'Alessandro, Pietro
   Arduino, Bruno
   Carbone, Ilma Floriana
   Insabato, Luigi
   Ribuffo, Diego
   Zullo, Fulvio
TI Use of Negative Pressure Wound Therapy Systems after Radical Vulvectomy
   for Advanced Vulvar Cancer
SO CANCER INVESTIGATION
LA English
DT Article
DE Cosmetic; patient satisfaction; wound; disinfection; skin closure
ID VACUUM-ASSISTED CLOSURE; LYMPHADENECTOMY
AB A retrospective cohort study was performed to evaluate the efficacy of negative pressure wound therapy in improving vulvectomy healing. Women who underwent radical vulvectomy with complete inguinofemoral lymphadenectomy for advanced vulvar cancer were divided into two groups according to immediate postoperative care: patients treated with negative pressure wound therapy using the device applied on the site of the wound (including vulva and inguinal region), and patients receiving conventional care. 18 patients were included in the study. 7 (38.9%) women were treated with negative pressure wound therapy immediately after the surgery and were included in the intervention group, and 11 (61.1%) patients were included in the control group. Women who received negative pressure wound therapy had significantly lower length of stay in the hospital (14.2 +/- 4.7 versus 17.1 +/- 6.1 days, mean difference -6.90 days, 95% confidence interval -11.91 to -1.89), and significantly lower length for wound healing (-31.90 days, 95% confidence interval -43.48 to -20.32). In conclusion, the utilization of the negative wound pressure therapy may contribute to reduce hospitalization after radical vulvectomy for vulvar cancer. Large and well-designed randomized trials with cost effectiveness analyses are needed to confirm these findings.
C1 [Quercia, Vittorio; Ribuffo, Diego] Sapienza Univ Rome, Dept Surg Pietro Valdoni, Rome, Italy.
   [Saccone, Gabriele; Raffone, Antonio; Favale, Mariano; D'Alessandro, Pietro; Arduino, Bruno; Zullo, Fulvio] Univ Naples Federico II, Sch Med, Dept Neurosci Reprod Sci & Dent, Via Sergio Pansini 5, I-80131 Naples, Italy.
   [Travaglino, Antonio; Insabato, Luigi] Univ Naples Federico II, Sch Med, Dept Adv Biomed Sci, Naples, Italy.
   [Carbone, Ilma Floriana] Osped Maggiore Policlin Milano, Milan, Italy.
C3 Sapienza University Rome; University of Naples Federico II; University
   of Naples Federico II; IRCCS Ca Granda Ospedale Maggiore Policlinico
RP Raffone, A (通讯作者)，Univ Naples Federico II, Sch Med, Dept Neurosci Reprod Sci & Dent, Via Sergio Pansini 5, I-80131 Naples, Italy.
EM anton.raffone@gmail.com
RI Raffone, Antonio/AAA-4943-2019; Travaglino, Antonio/M-7877-2019;
   Travaglino, Antonio/AAA-4943-2019; Zullo, Fulvio/K-3396-2016; RIBUFFO,
   Diego/HLG-3305-2023; Carbone, Ilma/X-6253-2019; Saccone,
   Gabriele/K-2792-2018
OI Raffone, Antonio/0000-0001-5443-2333; Travaglino,
   Antonio/0000-0003-4002-1618; Travaglino, Antonio/0000-0003-4002-1618;
   Zullo, Fulvio/0000-0003-3726-7561; RIBUFFO, Diego/0000-0002-1844-7850;
   Saccone, Gabriele/0000-0003-0078-2113
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NR 11
TC 8
Z9 8
U1 0
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0735-7907
EI 1532-4192
J9 CANCER INVEST
JI Cancer Invest.
PD OCT 20
PY 2020
VL 38
IS 8-9
BP 531
EP 534
DI 10.1080/07357907.2020.1817484
EA SEP 2020
PG 4
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA NZ1XI
UT WOS:000569193800001
PM 32877236
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Obeid, N
   Sharma, E
   Dunstan, M
   Nisar, P
   Trivedi, P
   Madani, R
   Scott, HJ
   Trickett, JP
   Bearn, PE
   Thomas, GP
AF Obeid, N.
   Sharma, E.
   Dunstan, M.
   Nisar, P.
   Trivedi, P.
   Madani, R.
   Scott, H. J.
   Trickett, J. P.
   Bearn, P. E.
   Thomas, G. P.
TI Negative pressure therapy for stoma closure sites-a nonrandomised case
   control study
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE PICO; Stoma closure
ID WOUND THERAPY; REVERSAL; INFECTIONS; TRIAL; RISK
AB Aim The PICO (Smith & Nephew, UK) dressing is a single use negative pressure wound therapy (NPWT) system that is designed to be used for up to 7 days for closed wounds. We aimed to assess its use for stoma closure wounds. Method We conducted a retrospective analysis of stoma reversal wounds from April 2018 to June 2019. The wound was partially closed with an absorbable subcutaneous suture in a purse-string fashion. A 15 cm x 15 cm PICO dressing was applied directly over this wound. A control group who had received partial purse string closure with packing over the same time period was identified. Patients were contacted and information collected using a questionnaire. The primary outcome measure was the number of visits for dressing changes in the community. Further information was collected about length of stay, time to resolution of pain and return to work. Results On average, the patients with PICO dressings attended the community nurses 1.9 times. The patients in the PICO group stated it took 1-2 weeks to return to full work/daily activities. The control group averaged attending the community nurse 11.9 times, and 33% had not returned to work/daily activities in 1-2 weeks. Conclusion Those who had a PICO dressing required fewer visits to the community nurse and the majority were able to return to work or resume usual activities within 1 to 2 weeks. This pilot study suggests that negative pressure dressings may be a useful aid for stoma closure site wounds.
C1 [Obeid, N.; Sharma, E.; Dunstan, M.; Nisar, P.; Trivedi, P.; Madani, R.; Scott, H. J.; Trickett, J. P.; Bearn, P. E.; Thomas, G. P.] Ashford & St Peters NHS Trust, Dept Colorectal Surg, Lyne, Surrey, England.
RP Obeid, N (通讯作者)，Ashford & St Peters NHS Trust, Dept Colorectal Surg, Lyne, Surrey, England.
EM noor.obeid@nhs.net
OI Dunstan, Matt/0000-0002-5383-9921
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 19
TC 6
Z9 7
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD JAN
PY 2021
VL 36
IS 1
BP 161
EP 167
DI 10.1007/s00384-020-03749-x
EA SEP 2020
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA PO1YK
UT WOS:000569306000001
PM 32929529
DA 2026-07-24
ER
PT J
AU Warren, JA
   Love, M
   Cobb, WS
   Beffa, LR
   Couto, FJ
   Hancock, BH
   Morrow, D
   Ewing, JA
   Carbonell, AM
AF Warren, Jeremy A.
   Love, Michael
   Cobb, William S.
   Beffa, Lucas R.
   Couto, Francisco J.
   Hancock, B. H.
   Morrow, D.
   Ewing, Joseph A.
   Carbonell, Alfredo M.
TI Factors affecting salvage rate of infected prosthetic mesh
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Mesh infection; Mesh salvage; Enteroprosthetic fistula; Subsequent
   abdominal operations
ID SUBSEQUENT ABDOMINAL OPERATIONS; INCISIONAL HERNIA REPAIR; SYNTHETIC
   MESH; OPEN PLACEMENT; RISK; COMPLICATIONS; PREDICTORS; EXPERIENCE;
   POSITION; OUTCOMES
AB Background: Prosthetic mesh infection (PMI) is a challenging complication of ventral hernia repair (VHR). The sparsity of data leaves only experience and judgment to guide surgical decision-making.
   Methods: Retrospective review of patients diagnosed with PMI. Subsequent abdominal operation (SAO) constitutes any intraabdominal operation occurring after the index hernia repair prior to PMI presen-tation. Any mesh removal was considered salvage failure. Analysis was performed using Chi-square test, Fishers Exact, or Mann-Whitney U test. Analyses completed using R Version 3.0.2.
   Results: We identified 213 instances of PMI. Most cases (58.7%) involved intraperitoneal mesh. Thirty-seven percent of patients had an SAO, only 25.3% of which were clean cases. Enteroprosthetic fistula occurred in 38 patients (17.8%). Mean time to presentation was 19.9 mos after index hernia repair or SAO for infection alone, and 48.1 mos when a fistula was present (p < 0.001). Percutaneous drainage was used to treat 29 cases, successfully in 10 (34.5%), 8 of which were macroporous polypropylene and 2 biologic mesh. Negative pressure wound therapy (NPWT) was used in 46 patients, but successful in only 16 (34.8%), all of which were macroporous polypropylene. Local wound care alone successfully salvaged only 16 of 85 meshes (18.8%), 13 of which were macroporous polypropylene. Macroporous polypropylene mesh was salvaged in 65% of cases overall, and 72.2% when in an extraperitoneal position. Mesh salvage was not possible in any case involving composite or PTFE mesh, and rarely for microporous poly-propylene (7.7%) multifilament polyester (4.2%), or intraperitoneal mesh (2.4%). Closure of the defect after mesh removal significantly lowers recurrence rate (p < 0.001).
   Conclusion: PMI involving composite, PTFE, multifilament polyester, or microporous polypropylene mesh requires explantation in nearly all cases. Infected macroporous polypropylene mesh in an extraperitoneal position is salvageable in most cases. Furthermore, the risk of secondary mesh infection after SAO, particularly with intraperitoneal mesh, should be considered during index VHR. (c) 2020 Elsevier Inc. All rights reserved.
C1 [Warren, Jeremy A.; Cobb, William S.; Carbonell, Alfredo M.] Univ South Carolina, Sch Med Greenville, Columbia, SC 29208 USA.
   [Warren, Jeremy A.; Love, Michael; Cobb, William S.; Beffa, Lucas R.; Couto, Francisco J.; Carbonell, Alfredo M.] Prisma Hlth Upstate, Div Minimally Access & Bariatr Surg, Dept Surg, Greenville, SC USA.
   [Hancock, B. H.; Morrow, D.] Prisma Hlth Upstate, Dept Surg Undergrad Res Program, Greenville, SC USA.
   [Ewing, Joseph A.] Prisma Hlth Upstate, Dept Qual Management, Greenville, SC USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; Prisma Health; Prisma Health; Prisma Health
RP Warren, JA (通讯作者)，Prisma Hlth Upstate, Dept Surg, 701 Grove Rd,ST 3, Greenville, SC 29605 USA.
EM jeremy.warren@prismahealth.org
OI Love, Wes/0009-0000-5201-0807; Carbonell, Alfredo/0009-0005-0787-0505;
   Morrow, Dillon/0000-0002-2096-1496; Hancock,
   Benjamin/0000-0001-9435-6224
CR Abdelfatah MM, 2015, HERNIA, V19, P135, DOI 10.1007/s10029-013-1165-9
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NR 36
TC 29
Z9 31
U1 0
U2 3
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD SEP
PY 2020
VL 220
IS 3
BP 751
EP 756
DI 10.1016/j.amjsurg.2020.01.028
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NP5JX
UT WOS:000570213500049
PM 32035628
DA 2026-07-24
ER
PT J
AU Grant-Freemantle, MC
   Ryan, EJ
   Flynn, SO
   Moloney, DP
   Kelly, MA
   Coveney, EI
   O'Daly, BJ
   Quinlan, JF
AF Grant-Freemantle, Marc C.
   Ryan, Eanna J.
   Flynn, Sean O.
   Moloney, Darren P.
   Kelly, Michael A.
   Coveney, Eamonn I.
   O'Daly, Brendan J.
   Quinlan, John F.
TI The Effectiveness of Negative Pressure Wound Therapy Versus Conventional
   Dressing in the Treatment of Open Fractures: A Systematic Review and
   Meta-Analysis
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Review
DE open fractures; negative pressure wound therapy; conventional wound
   dressing; deep infection; fracture nonunion; amputation; flap frequency;
   flap failure; hospital stay; ICU stay
ID INFECTED NONUNION; MANAGEMENT; NPWT
AB Objectives: To compare the efficacy of negative pressure wound therapy (NPWT) versus conventional dressings (CD) in the management of open fractures. Data Sources: A systematic search of English articles in the PubMed/MEDLINE, Embase, and the Cochrane Library through April 2019 comparing NPWT versus CD in the management of open fractures. Study Selection: Inclusion criteria were articles in English language, comparing NPWT with CD in skeletally mature individuals who had sustained an open fracture at any anatomical site, reporting on rates of deep infection, flap frequency, flap failure, nonunion, amputation, length of hospital, or intensive care unit stay. Data Extraction: Two authors independently extracted data from selected studies, and the data collected were compared with verify agreement. Data Synthesis: Pooled odds ratios were calculated for dichotomous outcomes, whereas continuous data were analyzed using the standard weighted mean difference. A random or fixed effect model was used depending on the level of heterogeneity between the studies. Conclusions: NPWT results in decreased likelihood of deep infection and flap failure compared with CD in the management of open fractures not directly amenable to early closure.
C1 [Grant-Freemantle, Marc C.; Flynn, Sean O.; Moloney, Darren P.; Kelly, Michael A.; Coveney, Eamonn I.; O'Daly, Brendan J.; Quinlan, John F.] Tallaght Univ Hosp, Dept Orthopaed, Dublin D24 NR0A, Ireland.
   [Ryan, Eanna J.] Tallaght Univ Hosp, Dept Surg, Dublin, Ireland.
   [O'Daly, Brendan J.; Quinlan, John F.] Royal Coll Surgeons Ireland, Dept Surg, Dublin, Ireland.
   [O'Daly, Brendan J.; Quinlan, John F.] Univ Dublin, Trinity Coll Dublin, Sch Med, Dublin, Ireland.
C3 Royal College of Surgeons in Ireland - RCSI; Trinity College Dublin
RP Grant-Freemantle, MC (通讯作者)，Tallaght Univ Hosp, Dept Orthopaed, Dublin D24 NR0A, Ireland.
EM marcfreemantle@rcsi.ie
RI ; Ryan, Éanna/H-6829-2019; Quinlan, John/AAQ-3286-2021
OI Flynn, Seán/0000-0002-0106-0887; Ryan, Éanna/0000-0003-2609-0836;
   Quinlan, John/0000-0003-3806-415X
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NR 36
TC 24
Z9 31
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD MAY
PY 2020
VL 34
IS 5
BP 223
EP 230
DI 10.1097/BOT.0000000000001750
PG 8
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA NP5OW
UT WOS:000570226500009
PM 32079890
DA 2026-07-24
ER
PT J
AU Anagnostakos, K
   Thiery, A
   Sahan, I
AF Anagnostakos, Konstantinos
   Thiery, Andreas
   Sahan, Ismail
TI Retained Negative Pressure Wound Therapy Foams as a Cause of Infection
   Persistence
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; vacuum-assisted closure; polyurethane
   foam; retained foam; infection persistence
ID VACUUM-ASSISTED CLOSURE; BACTERIAL LOAD; BIOFILM FORMATION;
   RISK-FACTORS; DRESSINGS; COMPLICATIONS; MANAGEMENT; CANDIDA
AB Significance: Negative pressure wound therapy (NPWT) has become a valuable adjunct in the treatment of acute and chronic wounds in several surgical disciplines. Retained foams are among its side effects, and they pose a rare but devastating complication at the site of this therapy, which might be associated with wound-healing complications, infection persistence, repeated surgical revisions, and prolonged antibiotic courses.
   Recent Advances: In the past 15 years, an increasing number of studies have identified this potential problem. Although the exact incidence remains unknown, initial studies have indicated rates of up to 10% in large collectives being treated by NPWT.
   Critical Issues: The lack of radiopaque markers does not allow for the visual control of retained foams using plain radiographs. Further imaging methods (e.g., CT and MRI) also do not help in adequate differential diagnosis. The lack of routine documentation of the number, type, and localization of the inserted foam(s) and unplanned surgery with a different surgical team pose risk factors for foam retainment.
   Future Directions: Introducing new documentation records for wounds treated with NPWT is recommended. At foam removal, all dressing materials should be examined for integrity. The development of foams with radiopaque markers by the industry, such as those routinely used in surgical gauze swabs, might also be a useful step to minimize the risk of foam retainment within wounds.
C1 [Anagnostakos, Konstantinos; Thiery, Andreas; Sahan, Ismail] Klinikum Saarbrucken, Ctr Orthoped & Trauma Surg, Dept Orthoped, Winterberg 1, D-66119 Saarbrucken, Germany.
RP Anagnostakos, K (通讯作者)，Klinikum Saarbrucken, Ctr Orthoped & Trauma Surg, Dept Orthoped, Winterberg 1, D-66119 Saarbrucken, Germany.
EM k.anagnostakos@web.de
RI Anagnostakos, Konstantinos/MGC-8753-2025
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NR 66
TC 8
Z9 10
U1 0
U2 13
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD DEC 1
PY 2021
VL 10
IS 12
BP 699
EP 710
DI 10.1089/wound.2019.1088
EA SEP 2020
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA US6EF
UT WOS:000570577100001
PM 32870776
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Lv, ZM
   Wang, QS
   Jia, R
   Ding, WY
   Shen, Y
AF Lv, Zhenmu
   Wang, Qiusheng
   Jia, Rui
   Ding, Wenyuan
   Shen, Yong
TI Pelnac® Artificial Dermis Assisted by VSD for Treatment of Complex Wound
   with Bone/Tendon Exposed at the Foot and Ankle, A Prospective Study
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Article
DE Pelnac; artificial dermis; vacuum sealing drainage (VSD); large skin and
   soft-tissue defect; prospective study
ID TISSUE DEFECTS; RECONSTRUCTION; SKIN; SUBSTITUTE; MANAGEMENT; CLOSURE
AB Purpose:This study aims to assess the efficacy and safety of Pelnac dermal regeneration template assisted by vacuum sealing drainage (VSD) and a split-thickness skin graft to cover the large skin and soft-tissue defects at foot and ankle.Methods:This study began from March 2013, up to February 2017. A total of 16 patients met the inclusion and exclusion criteria and were included. For every patient, 2 separate operations were performed, the first being thorough debridement of necrotic tissues immediate coverage of VSD at continuous negative pressure suction, and the second being the autologous split-thickness skin graft. At each follow-up, relevant data were documented.Results:The average follow-up was 16.5 months (range, 12 to 42 months). No infections, hematoma, or seroma were observed. 13 out of 16 patients had a complete skin graft "take" (100%). Patients' satisfaction of esthetic appearance was 76.5 +/- 5.2/100. The VSS value was 2.2 +/- 2.1, representing a good result. Regarding the sensory recovery, the response "normal or near normal" could be obtained in 14/16 patients. Mean AROM for extension/flexion of the ankle was 48.5 +/- 4.8 degrees (range 35-62 degrees), and 93.7% (15/16) of patient could obtain a satisfying functional result.Conclusions:Our report indicated Pelnac provided an effective method for management of complex wounds with underlying bone or tendons exposed.
C1 [Lv, Zhenmu; Ding, Wenyuan; Shen, Yong] Hebei Med Univ, Dept Spine Surg, Hosp 3, Shijiazhuang, Hebei, Peoples R China.
   [Lv, Zhenmu; Wang, Qiusheng; Jia, Rui] Peoples Liberat Army, Hosp 252, Dept Hand & Foot Surg, Baoding 071000, Hebei, Peoples R China.
   [Ding, Wenyuan; Shen, Yong] Key Lab Biomech Hebei Prov, Shijiazhuang 050051, Hebei, Peoples R China.
C3 Hebei Medical University
RP Lv, ZM (通讯作者)，Hebei Med Univ, Dept Spine Surg, Hosp 3, Shijiazhuang, Hebei, Peoples R China.; Lv, ZM (通讯作者)，Peoples Liberat Army, Hosp 252, Dept Hand & Foot Surg, Baoding 071000, Hebei, Peoples R China.
OI Ding, Wenyuan/0000-0002-7257-4316
CR Baryza Mary Jo, 1995, Journal of Burn Care and Rehabilitation, V16, P535, DOI 10.1097/00004630-199509000-00013
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NR 24
TC 23
Z9 30
U1 0
U2 12
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0894-1939
EI 1521-0553
J9 J INVEST SURG
JI J. Invest. Surg.
PD AUG 8
PY 2020
VL 33
IS 7
BP 636
EP 641
DI 10.1080/08941939.2018.1536177
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NR4BY
UT WOS:000571509200008
PM 32643478
DA 2026-07-24
ER
PT J
AU Duan, HJ
   He, YQ
   Zhang, HB
   Wang, F
   Chen, S
   Wang, J
AF Duan, Hongjie
   He, Yanqi
   Zhang, Hengbo
   Wang, Fang
   Chen, Shuai
   Wang, Jue
TI Vacuum sealing drainage with instillation in the treatment of
   necrotising soft-tissue infection: a retrospective analysis
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE debridement; necrotising soft-tissue infection; vacuum sealing drainage
   with instillation; wound healing
ID LABORATORY RISK INDICATOR; PRESSURE WOUND THERAPY; FASCIITIS
AB Objective: Necrotising soft-tissue infection is a rare but life-threatening infectious disease with high morbidity and mortality. It is typically caused by toxin-producing bacteria and characterised clinically by a very rapid progression of the disease with significant local tissue destruction. In this study, we intend to explore effective wound management to control the invasive infection and to decrease the high mortality.
   Method: This retrospective analysis explored the wound management and mortality in patients with necrotising soft-tissue infection. Extensive debridement, vacuum sealing drainage (VSD) with normal saline instillation combined with broad-spectrum or sensitive antibiotics, and supportive therapies were used.
   Results: All 17 patients included in the analysis survived. The microbiology of 11 patients was found to be polymicrobial. Of the patients, 14 were discharged with completely healed wounds and three were transferred to a local hospital after the systemic and invasive wound infection was controlled.
   Conclusion: Our experiences revealed the outstanding effect of VSD with instillation in removing the debris of necrotising tissue on the wound bed, in the continual and complete drainage of wound exudates, and in prompting wound healing.
C1 [Duan, Hongjie; He, Yanqi; Zhang, Hengbo; Wang, Fang; Chen, Shuai; Wang, Jue] Peoples Liberat Army Gen Hosp, Dept Burns & Traumat Surg, Hainan Branch, Sanya 572013, Peoples R China.
C3 Chinese People's Liberation Army General Hospital
RP Duan, HJ (通讯作者)，Peoples Liberat Army Gen Hosp, Dept Burns & Traumat Surg, Hainan Branch, Sanya 572013, Peoples R China.
EM duanhongjie@hotmail.com
RI Wang, Jue/PSM-2082-2026; Duan, Hongjie/HCI-0703-2022
OI Duan, Hongjie/0000-0001-9037-4679; Wang, Jue/0000-0003-2375-3753
FU National Natural Scientific Foundation of China [81171807]; Hainan
   Province Natural Scientific Foundation [817348]
FX The authors would like to thank all staff from the Emergency Department
   and ICU at the Hainan Branch of PLA General Hospital, Sanya, China, for
   their cooperation with monitoring and treatment. This work was supported
   partly by grants from the National Natural Scientific Foundation of
   China (#81171807) and Hainan Province Natural Scientific Foundation
   (#817348).
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NR 21
TC 20
Z9 31
U1 0
U2 13
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2020
VL 29
IS 9
BP 510
EP 517
DI 10.12968/jowc.2020.29.9.510
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA NS1AC
UT WOS:000571991400006
PM 32924816
DA 2026-07-24
ER
PT J
AU Ye, CJ
   Zhang, YH
   Han, CM
   Mao, SL
   Ni, LF
   Liu, J
   Wu, JM
   Zhang, JF
AF Ye, Chunjiang
   Zhang, Yuanhai
   Han, Chunmao
   Mao, Shulei
   Ni, Liangfang
   Liu, Jia
   Wu, Junmei
   Zhang, Jianfen
TI A Wound Treatment Strategy for "Super Long-Term Difficult-to-Heal
   Wounds": A Single-Center Retrospective Study
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE negative pressure wound therapy; chronic wounds; autologous scalp
   grafting; elderly patients
ID VACUUM-ASSISTED CLOSURE; LOWER-LIMB; THERAPY; ULCERS; MULTICENTER;
   MANAGEMENT; MATRIX; REPAIR
AB Chronic wounds are a challenge for clinicians. Treating chronic wounds in elderly patients is difficult due to comorbidities and poor immunity, tissue renewal, and regeneration. This study shared the therapeutic experiences of 40 patients with super long-term difficult-to-heal wounds and to describe the effects of negative pressure wound therapy (NPWT)-assisted debridement and autologous scalp grafting. Elderly patients with chronic wounds for more than 60 years who underwent NPWT-assisted debridement and autologous scalp grafting between 2015 and 2017 were retrospectively analyzed. Forty patients were identified and analyzed. Among all patients, the average wound area was 56 (interquartile range 30-90) cm(2). The wound infection rate was 82.1%, and that before the first autologous scalp grafting was 51.3%. The average total number of surgeries was 3, and the number of times the NPWT device was replaced was once. A total of 97.4% of patients had one autologous scalp grafting performed. The transplanted scalp survived completely in 97.4% of patients. One hundred percent of patients had no postoperative complications and healed. The average wound healing time was 34.5 +/- 10.1 days. This study showed that NPWT-assisted debridement and autologous scalp grafting have the advantages of high survival rate of the skin and decreased wound recurrence and may be a suitable treatment for super long-term difficult-to-heal wounds in elderly patients.
C1 [Ye, Chunjiang; Zhang, Yuanhai; Mao, Shulei; Ni, Liangfang; Liu, Jia; Wu, Junmei; Zhang, Jianfen] Zhejiang Quhua Hosp, Quzhou, Peoples R China.
   [Han, Chunmao] Zhejiang Univ, Affiliated Hosp 2, Coll Med, Hangzhou, Peoples R China.
C3 Zhejiang University
RP Ye, CJ (通讯作者)，Zhejiang Quhua Hosp, Dept Burns & Plast Surg, 62 Wenchang Rd, Quzhou 324004, Zhejiang, Peoples R China.
EM 5269639@qq.com
FU Basic Public Welfare Research Program of Zhejiang Province
   [LGF18H150001]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Basic
   Public Welfare Research Program of Zhejiang Province (LGF18H150001).
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NR 49
TC 0
Z9 0
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2022
VL 21
IS 4
BP 483
EP 491
AR 1534734620960292
DI 10.1177/1534734620960292
EA SEP 2020
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 6H4QA
UT WOS:000572775900001
PM 32962469
DA 2026-07-24
ER
PT J
AU Schulz, SA
   Schaefer, S
   Richards, DC
   Karagiannidis, C
   Thomaidis, P
   Heiss, MM
   Bulian, DR
AF Schulz, Sissy-A.
   Schaefer, Simone
   Richards, Dana C.
   Karagiannidis, Christian
   Thomaidis, Panagiotis
   Heiss, Markus M.
   Bulian, Dirk R.
TI The Need for Emergency Laparotomy With Open Abdomen Therapy in the
   Course of ECMO-A Retrospective Analysis of Course and Outcome
SO FRONTIERS IN SURGERY
LA English
DT Article
DE open abdomen; laparostoma; ECMO; abdominal compartment syndrome; NPWT
ID ABDOMINAL COMPARTMENT SYNDROME; EXTRACORPOREAL MEMBRANE-OXYGENATION;
   INTRAABDOMINAL HYPERTENSION; DECOMPRESSIVE LAPAROTOMY; CLOSURE;
   MANAGEMENT; PATIENT
AB Background:Abdominal compartment syndrome (ACS) can occur in patients placed on extra corporeal membrane oxygenation (ECMO). This implies the necessity of decompressive laparotomy followed by an open abdomen (OA) to prevent complications such as multi-organ-failure or death.
   Methods:We searched for ECMO patients in our hospital database between July 2015 and April 2020 and selected those with an emergency laparotomy and OA therapy. Of these, we analyzed only patients who were treated with an OA after establishing the ECMO regarding patient-related parameters like sex, age, height, weight, and indications for ECMO as well as outcome parameters like complete fascial closure rate, mortality, length of stay in intensive care unit (ICU), length and kind of OA therapy, number of surgical procedures, dressing changes concerning negative pressure wound therapy (NPWT), and number of surgical revisions.
   Results:In eight out of 421 patients (1.9%), a laparostoma had to be created during ECMO support. For temporary closure, either NPWT, abdominal packing, or both were used. The median length of OA therapy was 17 days, and the median length of stay in ICU was 42 days in total. The median number of surgical procedures and NPWT dressing changes was seven. In three of the eight patients, a surgical revision was necessary. The total mortality rate was 50%. In 75%, the fascia could be closed. Two patients died before final closure. In all deceased patients, an abdominal packing was necessary during the course of treatment; in the survivors, only once. No enteroatmospheric fistula or abscesses occurred.
   Conclusions:ACS in patients placed on ECMO is a very rare condition with a considerable mortality rate but high secondary closure rate of the fascia. A necessary abdominal packing due to a severe bleeding seems to be a risk factor with a potentially fatal outcome.
C1 [Schulz, Sissy-A.; Richards, Dana C.; Thomaidis, Panagiotis; Heiss, Markus M.; Bulian, Dirk R.] Witten Herdecke Univ, Cologne Merheim Med Ctr CMMC, Dept Abdominal Tumor Transplant & Vasc Surg, Cologne, Germany.
   [Schaefer, Simone; Karagiannidis, Christian] Witten Herdecke Univ, Cologne Merheim Med Ctr CMMC, ARDS & ECMO Ctr, Dept Pneumol & Crit Care Med, Cologne, Germany.
RP Bulian, DR (通讯作者)，Witten Herdecke Univ, Cologne Merheim Med Ctr CMMC, Dept Abdominal Tumor Transplant & Vasc Surg, Cologne, Germany.
EM dirk.bulian@uni-wh.de
RI Bulian, Dirk Rolf/GQY-7923-2022; Karagiannidis, M.D, Pr.
   Christian/PFI-9363-2025
OI Bulian, Dirk Rolf/0000-0002-1311-7326; Karagiannidis, M.D, Pr.
   Christian/0000-0003-3247-2849
CR Augustin P, 2010, ANN THORAC SURG, V90, pE40, DOI 10.1016/j.athoracsur.2010.06.039
   Bailey J, 2000, CRIT CARE, V4, P23, DOI 10.1186/cc646
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   Sun K, 2015, PLAST SURG-CHIR PLAS, V23, P218, DOI 10.1177/229255031502300407
NR 25
TC 8
Z9 8
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD SEP 4
PY 2020
VL 7
AR 63
DI 10.3389/fsurg.2020.00063
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NU7JV
UT WOS:000573817300001
PM 33102513
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fan, ZQ
   Yu, ZH
   Zheng, JZ
   Yu, BF
   Liu, DW
AF Fan, Zhi-Qiang
   Yu, Zhi-Hao
   Zheng, Jing-Zhou
   Yu, Bao-Fu
   Liu, De-Wu
TI Tibial cortex transverse distraction in treating diabetic foot ulcers:
   what are we concerned about?
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Tibial cortex transverse distraction; diabetic foot ulcers; effects;
   surgical complications; standard operative procedure; tibial fracture
ID ILIZAROV FIXATOR
AB Objective To assess the effect and complications of tibial cortex transverse distraction (TCTD) in treating diabetic foot ulcers and draw attention to the concerning issues of this procedure. Methods This case series included 30 patients with diabetic foot ulcers from four centers. The ulcers had not healed after >6 months. The patients then underwent TCTD combined with other procedures (debridement, vacuum sealing drainage, and others). All patients were followed up for >12 months postoperatively. Results Three patients underwent amputation because of aggravated infections. Tibial fractures occurred in two patients after surgery, and the fractures healed after 3 months of plaster fixation. Pin-site infections occurred in five patients, and the infected pin site healed after the patients underwent pin removal and dressing changes for 3.3 +/- 2.1 weeks. The ulcers of the other 27 patients healed by 13.5 +/- 8.2 weeks postoperatively, and the postoperative visual analog scale score was significantly lower than the preoperative score. Conclusions Although TCTD can be performed as an adjuvant treatment for diabetic foot ulcers, the effect should not be exaggerated and the complications should not be ignored. Further research is needed to propose a standard operative procedure and avoid postoperative complications such as tibial fractures.
C1 [Fan, Zhi-Qiang] Nanchang Univ, Jiangxi Prov Peoples Hosp, Dept Orthopaed Surg, 152 Ai Guo Rd, Nanchang 330006, Jiangxi, Peoples R China.
   [Fan, Zhi-Qiang; Liu, De-Wu] Nanchang Univ, Affiliated Hosp 1, Inst Burn, Nanchang, Jiangxi, Peoples R China.
   [Yu, Zhi-Hao] Yichun Peoples Hosp, Dept Orthopaed Surg, Yichun, Jiangxi, Peoples R China.
   [Zheng, Jing-Zhou] Nanchang Shuguang Hand & Foot Surg Hosp, Dept Orthopaed Surg, Nanchang, Jiangxi, Peoples R China.
   [Yu, Bao-Fu] Fudan Univ, Huashan Hosp, Jingan Branch, Dept Hand & Upper Extrem Surg, Shanghai, Peoples R China.
C3 Nanchang University; Nanchang University; Fudan University
RP Fan, ZQ (通讯作者)，Nanchang Univ, Jiangxi Prov Peoples Hosp, Dept Orthopaed Surg, 152 Ai Guo Rd, Nanchang 330006, Jiangxi, Peoples R China.
EM medical2018@sohu.com
CR Armstrong DG, 2017, NEW ENGL J MED, V376, P2367, DOI 10.1056/NEJMra1615439
   Chen Y, 2020, CLIN ORTHOP RELAT R, V478, P836, DOI 10.1097/CORR.0000000000001075
   Fu XL, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3160
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P249, DOI 10.1097/00003086-198901000-00038
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P263
   Inam M, 2015, J PAK MED ASSOC, V65, pS94
   Khan MS, 2015, J PAK MED ASSOC, V65, pS147
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   Liu YS, 2020, BMC MUSCULOSKEL DIS, V21, DOI 10.1186/s12891-020-03335-w
   Meloni M, 2020, J CLIN MED, V9, DOI 10.3390/jcm9061780
   Richards M, 1998, CLIN ORTHOP RELAT R, pS191
NR 11
TC 13
Z9 16
U1 0
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD SEP
PY 2020
VL 48
IS 9
AR 0300060520954697
DI 10.1177/0300060520954697
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA NV7VC
UT WOS:000574523200001
PM 32951489
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mallik, D
   Siddeek, RAT
   Ravi, B
   Sharda, P
AF Mallik, Dhiraj
   Siddeek, Rohik Anjum T.
   Ravi, Bina
   Sharda, Prateek
TI Case Series of Necrotising Soft Tissue Infection of Breast-Management
   with Literature Review
SO INDIAN JOURNAL OF SURGERY
LA English
DT Review
DE Necrotising soft tissue infection; Breast NSTI; MRI; LRINEC
ID FASCIITIS; RARE
AB Necrotising soft tissue infection (NSTI) is defined as a progressive necrosis and infectious state of soft tissue with diverse clinical manifestation. NSTI of breast is an uncommon phenomenon which requires aggressive treatment with broad spectrum antibiotics, serial debridement and dressings. Usage of hyperbaric oxygen therapy or negative pressure wound therapy has added a new milestone in management. Here, we have discussed management of three different patients of NSTI breast with literature review.
C1 [Mallik, Dhiraj; Siddeek, Rohik Anjum T.; Ravi, Bina; Sharda, Prateek] All India Inst Med Sci, Integrated Breast Care Ctr IBCC, Rishikesh, India.
C3 All India Institute of Medical Sciences (AIIMS) Rishikesh
RP Mallik, D (通讯作者)，All India Inst Med Sci, Integrated Breast Care Ctr IBCC, Rishikesh, India.
EM dhirajmallik09@gmail.com
RI sharda, prateek/GZN-0548-2022
OI sharda, prateek/0000-0002-9682-675X; RAVI, BINA/0000-0001-8894-6674;
   Anjum T Siddeek, Rohik/0000-0002-6106-2630; Mallik,
   Dhiraj/0000-0002-6023-4701
CR Eugster T, 1997, Swiss Surg, V3, P117
   Fayman K, 2017, INT J SURG CASE REP, V31, P221, DOI 10.1016/j.ijscr.2017.01.049
   Gupta A, 2019, J WOUND CARE, V28, P775, DOI 10.12968/jowc.2019.28.11.775
   Marongiu F, 2017, INT WOUND J, V14, P349, DOI 10.1111/iwj.12607
   Shah J, 2001, BRIT J PLAST SURG, V54, P67, DOI 10.1054/bjps.2000.3461
   Simonen SME, 2006, EPIDEMIOL INFECT, V134, P293, DOI 10.1017/S095026880500484X
   Wong CH, 2008, PLAST RECONSTR SURG, V122, p151E, DOI 10.1097/PRS.0b013e318186cd92
   Yang BB, 2015, JPRAS OPEN, V6, P15, DOI [10.1016/j.jpra.2015.05.002, DOI 10.1016/J.JPRA.2015.05.002]
NR 8
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD JUN
PY 2021
VL 83
IS SUPPL 2
SU 2
BP 556
EP 559
DI 10.1007/s12262-020-02624-x
EA OCT 2020
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XV3VI
UT WOS:000574720700001
DA 2026-07-24
ER
PT J
AU Kanapathy, M
   Mantelakis, A
   Khan, N
   Younis, I
   Mosahebi, A
AF Kanapathy, Muholan
   Mantelakis, Angelos
   Khan, Natasha
   Younis, Ibby
   Mosahebi, Afshin
TI Clinical application and efficacy of negative pressure wound therapy
   with instillation and dwell time (NPWTi-d): A systematic review and
   meta-analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE negative pressure wound therapy with instillation; NPWTi-d; Veraflo
ID SALINE
AB This study evaluates the current clinical evidence of Negative Pressure Wound Therapy with Instillation and dwell time (NPWTi-d) to establish its clinical application and efficacy. MEDLINE, EMBASE, and CENTRAL databases were searched from 1946 to July 2019 for studies reporting clinical outcomes on wounds treated with NPWTi-d. The primary outcome was proportion of wounds with complete healing. The secondary outcomes were mean time for healing, NPWTi-d settings, cost, length of stay, and adverse events. Thirteen articles were included with a total of 624 wounds in 542 patients involving wounds of various aetiology. The pooled proportion of wound that achieved complete healing was 93.65% (95%CI: 84.02-99.04). Normal saline was the most commonly used instillation solution with the mean dwell time of 14.23 minutes (95%CI: 10.88-17.59) and instillation cycle every 4.17 +/- 2.32 hourly. The mean therapy duration was 10.69 days (95%CI: 10.46-10.91) with daily cost of $194.80. The mean hospital stay was 18.1 days (95%CI: 17.20-19.00). There were no severe adverse effects reported. NPWTi-d is an adjuntive therapy to aid complete healing of the vast majority of wounds. However, the current data are limited by the lack of level 1 evidence.
C1 [Kanapathy, Muholan; Mosahebi, Afshin] UCL, Div Surg & Intervent Sci, London, England.
   [Kanapathy, Muholan; Younis, Ibby; Mosahebi, Afshin] Royal Free NHS Fdn Trust Hosp, Dept Plast & Reconstruct Surg, London, England.
   [Mantelakis, Angelos] Lewisham & Greenwich NHS Trust, Dept Ear Nose & Throat Surg, London, England.
   [Khan, Natasha] Imperial Coll Healthcare NHS Fdn Trust, Charing Cross Hosp, Dept Plast & Reconstruct Surg, London, England.
C3 University of London; University College London; Imperial College London
RP Mantelakis, A (通讯作者)，Lewisham & Greenwich NHS Trust, London SE13 6LH, England.
EM aggelosmantelakis@yahoo.com; ibbyyounis@hotmail.com
RI ; Kanapathy, Muholan/B-2225-2016
OI Mantelakis, Angelos/0000-0001-7109-943X; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Broder K., 2010, WOUNDS, V22, pE13
   Chowdhry SA, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002087
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   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Kim PJ, 2013, PLAST RECONSTR SURG, V132, P1569, DOI 10.1097/PRS.0b013e3182a80586
   Lessing C, 2011, WOUNDS, V23, P309
   Lessing MC, 2013, EPLASTY, V13, pe51
   Ludolph I, 2018, INT WOUND J, V15, P978, DOI 10.1111/iwj.12958
   Milcheski Dimas André, 2017, Rev. Col. Bras. Cir., V44, P348, DOI [10.1590/0100-69912017004008, 10.1590/0100-69912017004008]
   NICE, 2019, VAC VER THER SYST IN
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NR 24
TC 12
Z9 15
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2020
VL 17
IS 6
BP 1948
EP 1959
DI 10.1111/iwj.13487
EA OCT 2020
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA PE3BU
UT WOS:000574913400001
PM 33016602
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Rotering, H
   Al Shakaki, M
   Welp, H
   Dell'Aquila, AM
AF Rotering, Heinrich
   Al Shakaki, Mosab
   Welp, Henryk
   Dell'Aquila, Angelo M.
TI Preliminary Results of a New Treatment Strategy for Relapsed Left
   Ventricular Assist Device-Specific Infections
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID COLD ATMOSPHERIC PLASMA; MANAGEMENT; DIAGNOSIS; CONSENSUS; TRIAL; PUMP
AB Background. Relapsed ventricular assist device-specific infections are associated with high morbidity, mortality, and hospital costs. A new combination of cold atmospheric plasma and special dressing technique with negative pressure wound therapy with an additional underlay of carbon cloth and hypochlorite rinsing solutions has been developed and reported in this study.
   Methods. Between January 2016 and January 2018, 9 patients with relapsed infected driveline or pump pocket infection were treated with this new combined strategy. The primary endpoint was complete wound healing without recurrence of infection, defined as the presence at the same site within the first year after treatment. The secondary endpoint was control of infection, defined as a marked reduction of the infected area.
   Results. After a median treatment time of 3 weeks, an immediate response was observed in all patients, and complete healing was achieved in 6 patients. Five patients met the primary endpoint, and infection did not recur after a median follow-up of 17.5 (range, 12.1 to 21.8) months. One patient underwent heart transplantation 6 months after successful wound treatment (complete wound healing). The remaining 3 patients were discharged with controlled infection. After a median follow-up of 5.7 months, 1 destination therapy patient died at home, and 2 patients underwent urgent heart transplantation because of recurrence of infection caused by Pseudomonas aeruginosa. Side effects were not observed.
   Conclusions. The new combination treatment offers a promising option for patients with ventricular assist device-relapsed infection. Despite this, further studies are warranted to confirm those encouraging preliminary results. (C) 2020 by The Society of Thoracic Surgeons
C1 [Rotering, Heinrich; Al Shakaki, Mosab; Welp, Henryk; Dell'Aquila, Angelo M.] Univ Hosp Munster, Dept Cardiac Surg, Munster, Germany.
C3 University of Munster
RP Dell'Aquila, AM (通讯作者)，Univ Hosp, Dept Thorac & Cardiovasc Surg, Albert Schweitzer Campus 1, D-48149 Munster, Germany.
EM am.dellaquila@gmail.com
RI Dell'Aqula, Angelo M/AAJ-6462-2021
OI Dell'Aqula, Angelo M/0000-0002-5748-4275
FU Hounslow, Middlesex, United Kingdom
FX The MicroPlaSter device was lent free of charge for treatment in the
   period from January 2016 to March 2017 by Adtec Healthcare, Hounslow,
   Middlesex, United Kingdom.
CR ActiMaris, GEN INF ACTIMARIS SE
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   Rotering H., 2016, VIVANO SPECTRUM CONV, P28
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   Sharma V, 2012, ANN THORAC SURG, V94, P1381, DOI 10.1016/j.athoracsur.2012.05.074
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   Weiss M, 2017, J MED VIROL, V89, P952, DOI 10.1002/jmv.24701
NR 28
TC 5
Z9 6
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2020
VL 110
IS 4
BP 1302
EP 1307
DI 10.1016/j.athoracsur.2020.02.007
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA NW7VM
UT WOS:000575226700029
PM 32169499
DA 2026-07-24
ER
PT J
AU Du, WB
   He, LH
   Wang, LX
   Hu, HH
   Zhou, HT
   Bao, GN
   Chen, RL
   Shen, FX
   Quan, RF
AF Du, Weibin
   He, Lihong
   Wang, Lixiang
   Hu, Huahui
   Zhou, Huateng
   Bao, Guanai
   Chen, Rongliang
   Shen, Fuxiang
   Quan, Renfu
TI Experimental vascular protective shield combined with vacuum sealing
   drainage prevents pressure on exposed vessels and accelerates wound
   repair
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE Vascular protective shield vacuum sealing drainage (VSD); exposed
   vessels; early vascularization; wound repair
ID DIABETIC FOOT ULCERS; THERAPY; SKIN; EXTREMITY
AB Background: The sustained negative pressure created by vacuum sealing drainage (VSD) on exposed vascular wounds can result in blood vessel compression, embolism, or necrosis. 'I'he objective of this research \V a s to explore the ability of an experimental vascular protective shield combined with VSD to protect exposed vessels of the lower limbs and accelerate wound repair.
   Methods: (I) The vascular protective shield was prepared; (II) the material was subjected to acute toxicity and hemolysis tests; (III) and 30 New Zealand rabbits were divided into three groups: the control, VSD-only, and combined shield-VSD groups (with ten rabbits in each group). The wotmd-healing rate, myocardial function, wound histopathology; expression of angiogenesis markers, and exposed vascular compression of these three groups were compared on day 7.
   Results: (I) The internal structure of the material was smooth; and (II) no toxicity or death was observed in mice of any group. 'I'he hemolysis rate in the combined shield-VSD group was very low. (Ill) The combined shield -VS') group showed a higher wound -healing rate, and higher levels of cluster of differentiation 31 (CD31), vascular endothelial growth factor (VEGF), and platelet -derived growth factor (PDGF), than the other groups (P<0.05), along with a better tissue healing rate. (IV) Left ventricular pressure fluctuations in the combined shield-VSD group were smaller than those in the VSD-only group (P<0.05). (V) Blood vessels in the control and combined shield-VSD group were not damaged, but were damaged in the VSD-only group.
   Conclusions: The experimental vascular protective shield exhibited exceptional biosafety. The combination of this shield with VSD reduces influences on systolic and diastolic capacities of myocardium and avoids multiple compressions of exposed vessels, thus contributing to early vascularization of wounds arid wound repair.
C1 [Du, Weibin; He, Lihong; Wang, Lixiang; Hu, Huahui; Zhou, Huateng; Chen, Rongliang; Shen, Fuxiang; Quan, Renfu] Zhejiang Chinese Med Univ, Jiangnan Hosp, Res Inst Orthoped, Hangzhou 312001, Peoples R China.
   [Bao, Guanai] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Rehabil, Hangzhou, Peoples R China.
   [Bao, Guanai] Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Cancer Hospital; Chinese
   Academy of Sciences; University of Chinese Academy of Sciences, CAS;
   Chinese Academy of Sciences
RP Du, WB; Quan, RF (通讯作者)，Zhejiang Chinese Med Univ, Jiangnan Hosp, Res Inst Orthoped, Hangzhou 312001, Peoples R China.
EM dwbbdm@163.com; quanrenfu@126.com
FU National Natural Science Foundation of China [81904053]; Plan Guide
   Project of Hangzhou Technology Department [20171226Y93, 20171226Y96];
   Plan Project of Hangzhou Health Science and Technology Department
   [2018B030]; Great Technology Capture Project of Hangzhou Xiaoshan
   District [2017208, 2017214]
FX This work was supported by National Natural Science Foundation of China
   (No. 81904053), the Plan Guide Project of Hangzhou Technology Department
   (No. 20171226Y93, 20171226Y96), the Plan Project of Hangzhou Health
   Science and Technology Department (No. 2018B030), and the Great
   Technology Capture Project of Hangzhou Xiaoshan District (No. 2017208,
   2017214).
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NR 30
TC 3
Z9 3
U1 1
U2 11
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD SEP
PY 2020
VL 9
IS 5
BP 3059
EP 3069
DI 10.21037/apm-20-625
PG 11
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA NY8YP
UT WOS:000576670500071
PM 32819134
OA gold
DA 2026-07-24
ER
PT J
AU Lavery, LA
   Davis, KE
   La Fontaine, J
   Farrar, JD
   Bhavan, K
   Oz, OK
   Crisologo, PA
AF Lavery, Lawrence A.
   Davis, Kathryn E.
   La Fontaine, Javier
   Farrar, J. David
   Bhavan, Kavita
   Oz, Orhan K.
   Crisologo, Peter A.
TI Does negative pressure wound therapy with irrigation improve clinical
   outcomes? A randomized clinical trial in patients with diabetic foot
   infections
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Infection; Diabetes; Ulcer; Negative pressure wound therapy; Amputation;
   Osteomyelitis
ID MULTICENTER; INSTILLATION; ULCERS; OSTEOMYELITIS; MANAGEMENT; EFFICACY;
   SAFETY
AB Aim: To compare the efficacy of Negative Pressure Wound Therapy (NPWT) with and without irrigation with 0.1% polyhexanide-betaine.
   Methods: We randomized 150 subjects in a 16-week RCT to compare healing in patients with diabetic foot infections. NPWT delivered at 125 mm Hg continuous pressure. NPWT-I were administered at 30 cc per hour.
   Results: There were no differences clinical treatment or outcomes: wound area after surgery (18.5 +/- 19.0 vs. 13.4 +/- 11.1 cm2, p = 0.50), duration of antibiotics (39.7 +/- 21.0 vs. 38.0 +/- 24.6 days, p = 0.40), number of surgeries (2.3 +/- 0.67 vs. 2.2 +/- 0.59, p = 0.85), duration of NPWT (148.1 +/- 170.4 vs. 114.5 +/- 135.1 h, p = 0.06), healed wounds (58.7% vs. 60.0%, p = 0.86), time to healing (56.3 +/- 31.7 vs. 50.7 +/- 27.8, p = 0.53), length of stay (13.8 +/- 6.4 vs. 14.5 +/- 11.2 days, p = 0.42), re-infection (20.0% vs. 22.7%, p = 0.69, and re-hospitalization (17.3% vs. 18.7, p = 0.83).
   Conclusions: The addition of irrigation to NPWT did not change clinical outcomes in patients with diabetic foot infections. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Lavery, Lawrence A.; Davis, Kathryn E.; La Fontaine, Javier; Crisologo, Peter A.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd, Dallas, TX 75219 USA.
   [Farrar, J. David] Univ Texas Southwestern Med Ctr Dallas, Dept Immunol & Mol Biol, 5323 Harry Hines Blvd, Dallas, TX 75219 USA.
   [Bhavan, Kavita] Univ Texas Southwestern Med, Dept Internal Med, Infect Dis, 5323 Harry Hines Blvd, Dallas, TX 75219 USA.
   [Oz, Orhan K.] Univ Texas Southwestern Med Ctr Dallas, Dept Radiol, 5323 Harry Hines Blvd, Dallas, TX 75219 USA.
   [Crisologo, Peter A.] Univ Cincinnati, Med Ctr, Dept Surg, 231 Albert Sabin Way,ML 0513, Cincinnati, OH 45267 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas Southwestern
   Medical Center; University of Texas System; University of Texas
   Southwestern Medical Center; University of Texas System; University of
   Texas Southwestern Medical Center; University System of Ohio; University
   of Cincinnati
RP Lavery, LA; Crisologo, PA (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd, Dallas, TX 75219 USA.; Crisologo, PA (通讯作者)，Univ Cincinnati, Med Ctr, Dept Surg, 231 Albert Sabin Way,ML 0513, Cincinnati, OH 45267 USA.
EM larry.lavery@utsouthwestern.edu; crisolpa@ucmail.uc.edu
RI Crisologo, Peter/JZE-5379-2024; Oz, Orhan/GVT-7264-2022
OI Crisologo, Peter/0000-0002-5367-9235; Lavery,
   Lawrence/0000-0002-7920-9952; 
FU American Diabetes Association [1-15-TS-20, 1-17-ICTS-056]
FX This study was funded and supported by the American Diabetes Association
   award numbers [1-15-TS-20] and [1-17-ICTS-056].
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NR 20
TC 25
Z9 29
U1 0
U2 12
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD OCT
PY 2020
VL 220
IS 4
BP 1076
EP 1082
DI 10.1016/j.amjsurg.2020.02.044
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OA0ZX
UT WOS:000577526000052
PM 32139102
DA 2026-07-24
ER
PT J
AU Rupp, M
   Popp, D
   Alt, V
AF Rupp, Markus
   Popp, Daniel
   Alt, Volker
TI Prevention of infection in open fractures: Where are the pendulums now?
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
ID OPEN TIBIAL FRACTURES; PRESSURE WOUND THERAPY; BONE MORPHOGENETIC
   PROTEIN-2; SURGICAL SITE INFECTIONS; VANCOMYCIN POWDER;
   ANTIBIOTIC-PROPHYLAXIS; INITIAL MANAGEMENT; PULSATILE LAVAGE;
   LOWER-LIMB; GENTAMICIN
AB Soft tissue management and fracture fixation including initial external fixation in Gustilo-Anderson type II and type III open fractures are cornerstones in the treatment but details on timing and type of wound closure, irrigation and debridement, systemic and local antibiotics, antimicrobial-coated implants and the use of Bone Morphogenetic Protein-2 remain controversial. This article looks at current clinical evidence of these items for the management of open fractures. Timing of debridement and wound closure remains critical. Early debridement by an experienced team within 24 h seems adequate while gross contam-ination, a devascularized limb, a multi-injured patient and compartment syndrome require immediate surgical intervention. Wound closure during the first surgery was shown to result in reduced rates for infections and nonunion. If soft-tissue reconstruction is needed, it should be performed within the first 7 days. Regarding types of irrigation fluid, antiseptic and antibacterial solutions did not prove to be su-perior to saline. High pressure irrigation has not been demonstrated to be beneficial whereas antibiotic administration as soon as possible has been proven to be favorable. Administration of more than 72 h was not superior to shorter systemic antibiotic intervals. For Gustilo-Anderson type I and II, broad spec-trum antibiotic therapy is reasonable. Additional aminoglycosides for broader coverage are recommended in Gustilo-Anderson type III fractures. There is newer literature on the beneficial effects of the use of local antibiotics, e.g. by antibiotic beads. Coating of internal fixation devices is a modern approach to im-prove infection prophylaxis and gentamicin-coated implants have been demonstrated to be safe in clinical application. Vacuum assisted closure (VAC) could not evidence negative pressure wound therapy to re-duce infection risk, improve self-rated disability or quality of life in open fractures, however, enhance treatment costs. Recombinant human bone morphogenetic proteins (rhBMP)-2 showed promising data in Gustilo-Anderson type III open tibial shaft fractures with lower rates of invasive secondary procedures. In conclusion, there is evidence for thorough debridement and irrigation with saline, early soft tissue cover-age and the use of systemic and local antibiotics. Except for a short-term soft tissue coverage VAC seems not to be beneficial and rhBMP-2 is an additional tool in Gustilo-Anderson type III open fractures. (C) 2019 Elsevier Ltd. All rights reserved.
C1 [Rupp, Markus; Popp, Daniel; Alt, Volker] Univ Med Ctr Regensburg, Dept Trauma Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Alt, V (通讯作者)，Univ Med Ctr Regensburg, Dept Trauma Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
EM volker.alt@ukr.de
RI Rupp, Markus/ABH-5784-2022
OI Rupp, Markus/0000-0001-7221-3783
FU Osteosynthesis and Trauma Care Foundation (OTCF); Stryker
FX This paper is part of a supplement supported by the Osteosynthesis and
   Trauma Care Foundation (OTCF) through a research grant from Stryker.
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NR 71
TC 70
Z9 92
U1 0
U2 10
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD MAY
PY 2020
VL 51
SU 2
BP S57
EP S63
DI 10.1016/j.injury.2019.10.074
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA OA1OD
UT WOS:000577563000012
PM 31679836
DA 2026-07-24
ER
PT J
AU Mallow, PJ
   Tepsick, J
   Davis, KE
   Lavery, LA
AF Mallow, Peter J.
   Tepsick, Jon
   Davis, Kathryn E.
   Lavery, Lawrence A.
TI Cost-minimization analysis of negative pressure wound therapy
   technologies for the treatment of moderate-to-severe foot infections
SO JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
LA English
DT Article
DE cost-effectiveness analysis; health economics; negative pressure wound
   therapy; ulcer
ID VACUUM-ASSISTED CLOSURE; ULCERS; MULTICENTER; MEDICARE; BURDEN; TRIAL
AB Aim:The objective was to estimate the cost of care associated with two negative pressure wound therapy (NPWT) technologies used to treat patients admitted to the hospital with moderate-to-severe foot infections.Materials & methods:A decision tree simulation model was developed to estimate the hospital costs associated with two different NPWT technologies: Cardinal Health (TM) PRO (NPWT-C) and V.A.C. ULTA (TM) (NPWT-K). Clinical data were obtained from a previously completed single-site prospective trial. One-way and probabilistic sensitivity analyses were performed to gauge the robustness of the results.Results:The total expected per-patient costs were US$41,206 (SD: US$8,194) for NPWT-C and US$44,439 (SD: US$8,963) for NPWT-K.Conclusion:This study found that NPWT-C was expected to minimize the total costs over the episode of treatment. Larger and more clinically diverse studies are recommended to confirm these findings.
C1 [Mallow, Peter J.; Tepsick, Jon] Xavier Univ, Hlth Serv Adm, 3800 Victory Pkwy,Schott Hall 411, Cincinnati, OH 45207 USA.
   [Davis, Kathryn E.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
C3 University System of Ohio; Xavier University; University of Texas
   System; University of Texas Southwestern Medical Center
RP Mallow, PJ (通讯作者)，Xavier Univ, Hlth Serv Adm, 3800 Victory Pkwy,Schott Hall 411, Cincinnati, OH 45207 USA.
EM mallowp@xavier.edu
OI Lavery, Lawrence/0000-0002-7920-9952; Tepsick, Jon/0000-0001-6035-7800
CR Agency for Healthcare Quality and Research, 2019, HEALTHC COST UT PROJ
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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   Centers for Medicare & Medicaid Services (CMS), 2019, PHYS FEE SCHED LOOK
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   Yang CK, 2015, J VASC SURG, V61, P995, DOI 10.1016/j.jvs.2014.11.076
NR 26
TC 3
Z9 4
U1 0
U2 4
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 2042-6305
EI 2042-6313
J9 J COMP EFFECT RES
JI J. Comp. Eff. Res.
PD AUG
PY 2020
VL 9
IS 14
BP 1027
EP 1033
DI 10.2217/cer-2020-0127
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA OA7BG
UT WOS:000577935100005
PM 33034531
OA hybrid
DA 2026-07-24
ER
PT J
AU Lee, SY
   Seong, IH
   Park, BY
AF Lee, Seung Yeol
   Seong, Ik Hyun
   Park, Bo Young
TI When is the Critical Time for Soft Tissue Reconstruction of Open Tibia
   Fracture Patients?
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE reconstruction timing; free flap reconstruction; open fracture
ID FREE-FLAP RECONSTRUCTION; PRESSURE WOUND THERAPY; LOWER-EXTREMITY
   TRAUMA; LOWER-LIMB INJURY; MICROSURGICAL RECONSTRUCTION; COVERAGE;
   MANAGEMENT; TRANSPLANTATION
AB Background The timing of soft tissue reconstruction for soft-tissue defect in patients with open fractures in the lower extremity is known to be critical for successful outcomes. However, medical advances, including development of dressing materials and refinement in the microsurgical techniques, might have undergone modifications in this "critical period." There have been no studies on the role of timing on reconstructive outcomes. Thus, we have analyzed the effect of reconstruction timing on optimal surgical outcomes and complication rates in a single type of lower extremity injury.
   Methods Data of patients who underwent microvascular free tissue transfer with an open fracture in the lower extremity from 2014 through 2016 were retrospectively reviewed ( n =103). Surgical outcomes, including flap complication rate, flap revision rate, and long-term bony complications, were analyzed serially in accordance with time interval until coverage using the receiver operating characteristic (ROC) curve analysis. Significant factors with a p <0.05 in the univariate analysis were included in the multivariate logistic regression model to identify independent risk factors.
   Results A total of 46 patients (33 males and 13 females) were finally included in the study. Based on the association between surgical timing and flap-related complication rate, the best cutoff period for surgery was 33 days, with an area under the curve of 0.658 ( p =0.040). Further, in the revision rate, the cutoff period was identified as 10 days ( p =0.016). Regarding the incidence of bony complications, ROC curve showed that the maximal period until operation was 91 days with no influence on the occurrence of bony complications ( p =0.029).
   Conclusion Although the best method is an early reconstruction, many modalities such as negative pressure wound therapy play a role as a temporary measure. Our study suggests that the acute or early period for successful reconstruction might be extended compared with previous studies.
C1 [Lee, Seung Yeol] Hanyang Univ, Myongji Hosp, Dept Orthopaed Surg, Coll Med, Seoul, South Korea.
   [Seong, Ik Hyun; Park, Bo Young] Ewha Womans Univ, Sch Med, Dept Plast & Reconstruct Surg, 260 Gonghang Daero, Seoul 07804, South Korea.
C3 Hanyang University; Myongji Hospital; Ewha Womans University
RP Park, BY (通讯作者)，Ewha Womans Univ, Sch Med, Dept Plast & Reconstruct Surg, 260 Gonghang Daero, Seoul 07804, South Korea.
EM by.park@ewha.ac.kr
RI ; Lee, Seung/AAX-9451-2020
OI Park, Bo Young/0000-0003-4612-6672; 
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Science and ICT [NRF-2017R1D1A1B03035452,
   2019R1A2C2010150]
FX This researchwas supported by the Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Science and ICT (NRF-2017R1D1A1B03035452 and 2019R1A2C2010150).
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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NR 24
TC 10
Z9 11
U1 0
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD MAR
PY 2021
VL 37
IS 03
BP 249
EP 255
DI 10.1055/s-0040-1717151
EA OCT 2020
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QP0JH
UT WOS:000578212400006
PM 33058097
DA 2026-07-24
ER
PT J
AU Mba, UC
   Okenwa, WO
AF Mba, Uwakwe C.
   Okenwa, Wilfred O.
TI Experience with use of improvised negative pressure wound therapy in the
   management of wounds with exposed bone
SO TROPICAL DOCTOR
LA English
DT Article
DE Skin and connective tissue; physiology; musculoskeletal; physiology
ID VACUUM-ASSISTED CLOSURE
AB Wounds with exposed bone pose a significant challenge in healing. Negative pressure wound therapy has simplified reconstructive options. In economically constrained regions, this has been modified with materials that are affordable. Its effect on such wounds has not been well studied and so case summaries of 15 patients with 17 wounds who were managed with modified negative pressure wound therapy at Ntasiobi Specialist Hospital and ESUT Teaching Hospital between 2015 and 2019 were obtained. The procedure progressed satisfactorily in 88% of patients with granulation tissue covering the bones while the procedure was discontinued in 12%. The modified negative pressure wound therapy achieves similar results as the patented version and is recommended where resources are limited.
C1 [Mba, Uwakwe C.; Okenwa, Wilfred O.] Enugu State Univ, Teaching Hosp, Enugu, Nigeria.
   [Mba, Uwakwe C.] Ntasiobi Specialist Hosp, Enugu, Nigeria.
RP Mba, UC (通讯作者)，ESUT Teaching Hosp, Dept Surg, PMB 1030, Enugu, Nigeria.
EM ndiuwamba@gmail.com
RI Mba, Uwakwe/CAF-1686-2022
OI Mba, Uwakwe/0000-0001-9420-0385
CR Amouzou K, 2017, Nigerian Journal of Plastic Surgery, V13, P64, DOI 10.4103/njps.njps_14_17
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 20
TC 4
Z9 6
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0049-4755
EI 1758-1133
J9 TROP DOCT
JI Trop. Dr.
PD JAN
PY 2021
VL 51
IS 1
BP 6
EP 10
AR 0049475520962745
DI 10.1177/0049475520962745
EA OCT 2020
PG 5
WC Public, Environmental & Occupational Health; Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Tropical Medicine
GA QC0UJ
UT WOS:000578580300001
PM 33040691
DA 2026-07-24
ER
PT J
AU Zens, Y
   Barth, M
   Bucher, HC
   Dreck, K
   Felsch, M
   Gross, W
   Jaschinski, T
   Kölsch, H
   Kromp, M
   Overesch, I
   Sauerland, S
   Gregor, S
AF Zens, Yvonne
   Barth, Michael
   Bucher, Heiner C.
   Dreck, Katrin
   Felsch, Moritz
   Gross, Wolfram
   Jaschinski, Thomas
   Kolsch, Heike
   Kromp, Mandy
   Overesch, Inga
   Sauerland, Stefan
   Gregor, Sven
TI Negative pressure wound therapy in patients with wounds healing by
   secondary intention: a systematic review and meta-analysis of randomised
   controlled trials
SO SYSTEMATIC REVIEWS
LA English
DT Review
DE Negative-pressure wound therapy; Wound healing; Benefit assessment;
   Systematic review; Publication bias
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; CHRONIC LEG ULCERS;
   QUALITY-OF-LIFE; THICKNESS SKIN-GRAFTS; THE-ART TREATMENT; OPEN ABDOMEN;
   CLINICAL-TRIAL; OPEN FRACTURE; MANAGEMENT
AB Background: Negative pressure wound therapy (NPWT) is a widely used method of wound treatment. We performed a systematic review of randomised controlled trials (RCTs) comparing the patient-relevant benefits and harms of NPWT with standard wound therapy (SWT) in patients with wounds healing by secondary intention.
   Methods: We searched for RCTs in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and study registries (last search: July 2018) and screened reference lists of relevant systematic reviews and health technology assessments. Manufacturers and investigators were asked to provide unpublished data. Eligible studies investigated at least one patient-relevant outcome (e.g. wound closure). We assessed publication bias and, if feasible, performed meta-analyses, grading the results into different categories (hint, indication or proof of a greater benefit or harm).
   Results: We identified 48 eligible studies of generally low quality with evaluable data for 4315 patients and 30 eligible studies with missing data for at least 1386 patients. Due to potential publication bias (proportion of inaccessible data, 24%), we downgraded our conclusions. A meta-analysis of all wound healing data showed a significant effect in favour of NPWT (OR 1.56, 95% CI 1.15 to 2.13, p = 0.008). As further analyses of different definitions of wound closure did not contradict that analysis, we inferred an indication of a greater benefit of NPWT. A meta-analysis of hospital stay (in days) showed a significant difference in favour of NPWT (MD - 4.78, 95% CI - 7.79 to - 1.76, p = 0.005). As further analyses of different definitions of hospital stay/readmission did not contradict that analysis, we inferred an indication of a greater benefit of NPWT. There was neither proof (nor indication nor hint) of greater benefit or harm of NPWT for other patient-relevant outcomes such as mortality and adverse events.
   Conclusions: In summary, low-quality data indicate a greater benefit of NPWT versus SWT for wound closure in patients with wounds healing by secondary intention. The length of hospital stay is also shortened. The data show no advantages or disadvantages of NPWT for other patient-relevant outcomes. Publication bias is an important problem in studies on NPWT, underlining that all clinical studies need to be fully reported.
C1 [Zens, Yvonne; Dreck, Katrin; Felsch, Moritz; Gross, Wolfram; Jaschinski, Thomas; Kolsch, Heike; Kromp, Mandy; Overesch, Inga; Sauerland, Stefan] Inst Qual & Efficiency Hlth Care IQWiG, Mediapk 8, D-50670 Cologne, Germany.
   [Bucher, Heiner C.] Univ Hosp Basel, Basel Inst Clin Epidemiol & Biostat, Basel, Switzerland.
   [Bucher, Heiner C.] Univ Basel, Basel, Switzerland.
C3 University of Basel; Swiss School of Public Health (SSPH+); University
   of Basel
RP Zens, Y (通讯作者)，Inst Qual & Efficiency Hlth Care IQWiG, Mediapk 8, D-50670 Cologne, Germany.
EM Yvonne.Zens@iqwig.de
OI Zens, Yvonne/0000-0002-6301-9361
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 149
TC 44
Z9 56
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2046-4053
J9 SYST REV-LONDON
JI Syst. Rev.
PD OCT 10
PY 2020
VL 9
IS 1
AR 238
DI 10.1186/s13643-020-01476-6
PG 26
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OB6UB
UT WOS:000578603300003
PM 33038929
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Song, YP
   Wang, L
   Yuan, BF
   Shen, HW
   Du, L
   Cai, JY
   Chen, HL
AF Song, Yi-Ping
   Wang, Lei
   Yuan, Bao-Fang
   Shen, Hong-Wu
   Du, Lin
   Cai, Ji-Yu
   Chen, Hong-Lin
TI Negative-pressure wound therapy forIII/IVpressure injuries: A
   meta-analysis
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; RANDOMIZED-TRIAL;
   PREVALENCE; EXPRESSION; MANAGEMENT; DRESSINGS; SYSTEM; DEVICE; COST
AB This meta-analysis was conducted to identify the potential benefits and the efficacy of negative-pressure wound therapy (NPWT) for III/IV pressure injuries (PIs) compared with standard wound care (SWC). Sixteen RCTs with 629 patients were included in our analysis. The methodological quality was assessed by the Cochrane Collaboration Tool. The outcomes included complete ulcer healing rate, wound healing time, pain score, the frequency of dressing change, hospitalization cost, the condition of the exudate, and the wound improvement. The percentage of healing rate was 61.45% for the NPWT group and 36.90% for SWC (95% CI: 1.32-1.70). There were significant differences in wound healing time (WMD = -16.47 days, 95% [CI (-22.36, - 10.59) days,P <= .001]). The pain score and hospitalization cost in NPWT was lower compared with SWC group (WMD = -2.39, 95% CI [-3.47, -1.30],P <= .001); (SMD = -2.55, 95% CI [-4.07, -1.03],P < .01). The frequency of dressing change in both NPWT groups was greatly reduced (SMD = -3.61, 95% [CI (-4.57, - 2.66) times,P <= .001]). Our meta-analysis indicated that NPWT was associated with greater improvements in improving PIs and shorting healing time for III/IV PIs. However, this conclusion needs to be confirmed by high-quality multicenter RCTs.
C1 [Song, Yi-Ping; Du, Lin; Cai, Ji-Yu] Nantong Univ, Sch Med, Nantong, Jiangsu, Peoples R China.
   [Wang, Lei] Third Peoples Hosp Nantong, Informat Dept, Nantong, Jiangsu, Peoples R China.
   [Yuan, Bao-Fang; Shen, Hong-Wu] Nantong Univ, Nursing Dept, Affiliated Hosp, Nantong, Jiangsu, Peoples R China.
   [Chen, Hong-Lin] Nantong Univ, Sch Publ Hlth, Nantong, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Chen, HL (通讯作者)，Nantong Univ, Sch Publ Hlth, Nantong, Jiangsu, Peoples R China.
EM honglinyjs@126.com
OI Chen, Hong-Lin/0000-0003-0147-6863
FU Social and People's Livelihood Technology in Nantong city-General
   Project [MS12019038]
FX Social and People's Livelihood Technology in Nantong city-General
   Project, Grant/Award Number: MS12019038
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NR 58
TC 32
Z9 38
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN
PY 2021
VL 29
IS 1
BP 20
EP 33
DI 10.1111/wrr.12863
EA OCT 2020
PG 14
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA PT3DV
UT WOS:000579127300001
PM 32989919
DA 2026-07-24
ER
PT J
AU Holford, NC
AF Holford, Nicholas Charles
TI Negative-pressure wound therapy - does it lower the risk of
   complications with closed wounds following breast surgery?
SO EXPERT REVIEW OF MEDICAL DEVICES
LA English
DT Article
DE Negative Pressure; pico; wound therapy; wound complications; breast
   surgery
ID RECONSTRUCTION
AB Introduction:Breast surgery complications are important not only due to their morbidity and psychological impact, but also the delays that can occur for adjuvant treatment or the loss of implants in severe cases. There is growing evidence that negative pressure dressing on closed wounds can reduce the complications following surgery.Methods:This study aimed to assess whether negative-pressure dressings reduced complications in patients undergoing bilateral reduction mammoplasty with randomization of a side to negative pressure and standard care, fixation strips, on the contralateral side. This allowed patients to act as their own controls.Results:This study found a significant reduction in the rate of wound complications but used a wide definition for what constituted a wound complication.Discussion:This finding is mirrored in existing work with studies showing that negative-pressure therapy is a cost-effective intervention. Further work is required to validate this finding and targeting those at highest risk may be preferential.
C1 [Holford, Nicholas Charles] Reading Hosp, Royal Berkshire NHS Fdn Trust, Breast Surg Dept, Reading, Berks, England.
C3 Royal Berkshire Hospital
RP Holford, NC (通讯作者)，Royal Berkshire NHS Trust, Breast Surg Dept, Reading RG1 5AN, Berks, England.
EM Nicholas.holford@doctors.org.uk
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NR 16
TC 2
Z9 2
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1743-4440
EI 1745-2422
J9 EXPERT REV MED DEVIC
JI Expert Rev. Med. Devices
PD OCT 2
PY 2020
VL 17
IS 10
BP 1017
EP 1019
DI 10.1080/17434440.2020.1828058
EA OCT 2020
PG 3
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA OZ8JZ
UT WOS:000579382700001
PM 32964756
DA 2026-07-24
ER
PT J
AU Petca, A
   Negoita, S
   Petca, RC
   Calo, O
   Sinescu, RD
AF Petca, Aida
   Negoita, Silvius
   Petca, Razvan-Cosmin
   Calo, Oana
   Sinescu, Ruxandra Diana
TI Ether-Based Polyurethane Foam for Vacuum-Assisted Closure (VAC) of
   Complicated Postoperative Abdominal Wound Dehiscence
SO MATERIALE PLASTICE
LA English
DT Article
DE polyether foam; silver layer; NPWT; infected wounds; surgical
   complications
ID THERAPY; RISK
AB Background. The macroporous polyurethane ether, foam was introduced in the medical . field, as early as the 90 ties, for the Vacuum-assisted closure (V.A.C.) of a wound. We describe our experience after treating abdominal wound dehiscence in a group of elderly gynecological patients with NPWT (Negative Pressure Wound Therapy), using ether foam coated with a silver layer. We reviewed elderly patients chart data that underwent abdominal surgery complicated with wound dehiscence treated with VAC for eighteen months. In all patients, the system used was the standard GranuFoam Silver (TM) dressing (different extents), which was usually replaced every 48/72 h. A total of 15 consecutive female patients were included. The median age was 67.3 (58-71) years. Duration of VAC treatment was median 14.2 (11-34) days, and we saw an improvement in wound repair but also clearance of S.S.I. on the third day after applying V.A.C. Ulta (TM). Definitive secondary closure of the wound was obtained in all patients, as the infection's site clearance. The abdominal VAC treatment with GranuFoam Silver (TM) dressing in patients with infected abdominal wound dehiscence is safe and has proper patient compliance. The latest evolution of the silver foam polyether dressing, in conjunction with NPWT therapy, offers a better antimicrobial effect and shorter healing stage.
C1 [Petca, Aida; Negoita, Silvius; Petca, Razvan-Cosmin; Calo, Oana; Sinescu, Ruxandra Diana] Carol Davila Univ Med & Pharm, 8 Eroii Sanit Blvd, Bucharest 050474, Romania.
   [Petca, Aida] Elias Univ Emergency Hosp, Dept Obstet & Gynecol, 17 Marasti Blvd, Bucharest 011461, Romania.
   [Negoita, Silvius] Elias Univ Emergency Hosp, Dept Anaesthesiol & Crit Care, 17 Marasti Blvd, Bucharest 011461, Romania.
   [Petca, Razvan-Cosmin] Prof Dr Th Burghele Clin Hosp, Dept Urol, 20 Panduri Str, Bucharest 050653, Romania.
   [Sinescu, Ruxandra Diana] Elias Univ Emergency Hosp, Dept Plast Surg & Reconstruct Microsurg, 17 Marasti Blvd, Bucharest 011461, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Petca, RC (通讯作者)，Carol Davila Univ Med & Pharm, 8 Eroii Sanit Blvd, Bucharest 050474, Romania.; Petca, RC (通讯作者)，Prof Dr Th Burghele Clin Hosp, Dept Urol, 20 Panduri Str, Bucharest 050653, Romania.
EM drpetca@gmail.com
RI ; NEGOITA, SILVIUS/AAG-2433-2021; Petca, Razvan - Cosmin/AAH-2462-2020;
   /ABD-2479-2020; Petca, Aida/AAH-2462-2020
OI Petca, Razvan - Cosmin/0000-0003-4496-1535; Petca, Razvan -
   Cosmin/0000-0003-4496-1535; Petca, Aida/0000-0002-4890-0978
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   Singh D, 2020, PLAST RECONSTR SURG, V145, p839E, DOI 10.1097/PRS.0000000000006652
   van Ramshorst GH, 2010, WORLD J SURG, V34, P20, DOI 10.1007/s00268-009-0277-y
   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
   World Union of Wound Healing Societies (WUWHS), 2016, CLOS SURG INC MAN UN
NR 24
TC 3
Z9 3
U1 1
U2 5
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0025-5289
EI 2668-8220
J9 MATER PLAST
JI Mater. Plast.
PD JUN
PY 2020
VL 57
IS 2
BP 32
EP 38
DI 10.37358/MP.20.2.5348
PG 7
WC Materials Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA OC9BZ
UT WOS:000579451200004
OA hybrid
DA 2026-07-24
ER
PT J
AU Zhang, Y
   Tong, Y
   Chen, XJ
   Luo, JC
   Bi, Q
AF Zhang, Yin
   Tong, Yu
   Chen, Xinji
   Luo, Junchao
   Bi, Qing
TI Rapidly expanding giant neurofibroma of the back with intratumoral
   hematoma: a case report and literature review
SO BRITISH JOURNAL OF NEUROSURGERY
LA English
DT Review
DE rapidly expanding giant neurofibroma; intratumoral hematoma; case
   report; review
AB Neurofibromatosis type I is a common genetic disease that can lead to disfigurement, neurological and functional disorders. However, it is rare to meet the case which a huge mass is formed rapidly after neurofibroma ruptures. This case report describes a rare case of a 52-year-old female with a rapidly expanding mass on her back and mild anemia as the main symptoms. Physical examination showed a huge mass on the back and a surface ulceration with the diameter of 6 cm. Imaging examination revealed the abundant blood supply to the lesion. We performed preoperative arterial embolization, and surgical resection on the fifth day after embolization. After operation, proper blood transfusion and vacuum sealing drainage (VSD) were given. Through 9-months follow-up study, the incision of the patient recovered well and there was no sign of tumor recurrence. Therefore, this case report provides clinicians with valuable experience in the treatment for rapidly expanding neurofibroma.
C1 [Zhang, Yin; Bi, Qing] Bengbu Med Univ, Affiliated Hosp 1, Bengbu, Anhui, Peoples R China.
   [Tong, Yu; Luo, Junchao] Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou, Peoples R China.
   [Tong, Yu; Luo, Junchao] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
   [Chen, Xinji; Bi, Qing] Zhejiang Prov Peoples Hosp, Dept Orthoped Surg, Hangzhou, Zhejiang, Peoples R China.
   [Chen, Xinji; Bi, Qing] Hangzhou Med Coll, Peoples Hosp, Hangzhou, Zhejiang, Peoples R China.
C3 Bengbu Medical University; Wenzhou Medical University; Wenzhou Medical
   University; Hangzhou Medical College; Zhejiang Provincial People's
   Hospital; Hangzhou Medical College
RP Bi, Q (通讯作者)，Bengbu Med Univ, Affiliated Hosp 1, Bengbu, Anhui, Peoples R China.; Bi, Q (通讯作者)，Zhejiang Prov Peoples Hosp, Dept Orthoped Surg, Hangzhou, Zhejiang, Peoples R China.
EM bqzjsrmyy@163.com
OI TONG, YU/0000-0001-9895-6948
CR Cavallaro G, 2012, G CHIR, V33, P239
   Dogra Bharat B, 2013, Indian Dermatol Online J, V4, P195, DOI 10.4103/2229-5178.115515
   Hollander JE., 2011, SKIN SOFT TISSUE INJ
   JONES RG, 2010, BR J RADIOL, V83
   LITTLEWOOD AHM, 1983, BRIT J PLAST SURG, V36, P501, DOI 10.1016/0007-1226(83)90140-6
   Mikami T, 2020, BMC SURG, V20, DOI 10.1186/s12893-020-00761-4
   Tovo Filho Reinaldo, 2020, JAAD Case Rep, V6, P462, DOI [10.1016/j.jdcr.2020.02.023, 10.1016/j.jdcr.2020.02.023]
   Vélez R, 2013, CASE REP NEUROL MED, V2013, DOI 10.1155/2013/987623
   Yuan SM, 2015, J CRANIOFAC SURG, V26, pE405, DOI 10.1097/SCS.0000000000001873
NR 9
TC 1
Z9 2
U1 1
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0268-8697
EI 1360-046X
J9 BRIT J NEUROSURG
JI Br. J. Neurosurg.
PD NOV 2
PY 2023
VL 37
IS 6
BP 1709
EP 1713
DI 10.1080/02688697.2020.1834508
EA OCT 2020
PG 5
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA HC0R6
UT WOS:000579890300001
PM 33078971
DA 2026-07-24
ER
PT J
AU Schreiner, W
   Ludolph, I
   Dudek, W
   Horch, RE
   Sirbu, H
AF Schreiner, Waldemar
   Ludolph, Ingo
   Dudek, Wojciech
   Horch, Raymund E.
   Sirbu, Horia
TI Negative Pressure Wound Therapy Combined With Instillation for
   Sternoclavicular Joint Infection
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID SURGICAL-MANAGEMENT
AB Background. There is no consensus on the management of spontaneous sternoclavicular joint infection (SCJI). Negative pressure wound therapy (NPWT) has been widely accepted for SCJI. We reviewed our experience with the management of this condition comparing NPWT alone and NPWT combined with instillation and dwell time.
   Methods. We retrospectively analyzed the data of patients with spontaneous SCJI treated in our thoracic unit.
   Results. From March 2008 to October 2019, 27 patients (21 men and 6 women) underwent NPWT combined with muscle flap transfer after necrosectomy and chest wall resection for SCJI. The median age was 57.1 years (range, 35 to 85). Depending on management, the patients were divided into two groups: 16 patients with NPWT in group 1, and 11 patients with NPWT combined with instillation and dwell time in group 2. The severity of SCJI, extent of chest wall resection, and type of muscle flap were not significantly different (P = .35, P =.858, P = .705, respectively). Median duration of hospital stay and NPWT were shorter in group 2 (30 vs 25 days, and 20 vs 16 days, respectively). The required wound dressing changes were significantly lower in group 2 (P = .008). Statistical trend to higher bacterial eradication in group 2 was noted (P = .093). Postoperative complications including SCJI recurrence, wound seroma, and dehiscence were not significantly different between groups (P = .269).
   Conclusions. The NPWT combined with instillation and dwell time appears a useful strategy in patients with SCJI, leading to higher incidence of bacterial eradication and shorter wound care. (C) 2020 by The Society of Thoracic Surgeons
C1 Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Thorac Surg, Erlangen, Germany.
   Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Plast & Hand Surg, Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Schreiner, W (通讯作者)，Friedrich Alexander Univ Erlangen Nuremberg, Dept Thorac Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM waldemar.schreiner@uk-erlangen.de
RI Schreiner, Waldemar/ABG-9988-2021; /ABB-6254-2020; Horch,
   Raymund/H-8128-2019
CR Abu Arab W, 2011, EUR J CARDIO-THORAC, V40, P630, DOI 10.1016/j.ejcts.2010.12.037
   Burkhart HM, 2003, J THORAC CARDIOV SUR, V125, P945, DOI 10.1067/mtc.2003.172
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   Haddad M, 2002, ANN THORAC SURG, V74, P1225, DOI 10.1016/S0003-4975(02)03815-8
   Horch RE, 2020, EXPERT REV MED DEVIC, V17, P139, DOI 10.1080/17434440.2020.1714434
   Horch RE, 2018, ZBL CHIR, V143, P609, DOI 10.1055/a-0713-0517
   Joethy J, 2012, ARCH PLAST SURG-APS, V39, P643, DOI 10.5999/aps.2012.39.6.643
   Kachala SS, 2016, ANN THORAC SURG, V101, P2155, DOI 10.1016/j.athoracsur.2016.01.054
   Landreneau Rodney J, 2011, Ann Thorac Surg, V91, P261, DOI 10.1016/j.athoracsur.2010.08.059
   Le Pimpec-Barthes F, 2011, EUR J CARDIO-THORAC, V40, P634, DOI 10.1016/j.ejcts.2011.01.042
   Ludolph I, 2018, INT WOUND J, V15, P978, DOI 10.1111/iwj.12958
   Nusselt T, 2011, ARCH ORTHOP TRAUM SU, V131, P319, DOI 10.1007/s00402-010-1178-0
   Puri V, 2011, ANN THORAC SURG, V91, P257, DOI 10.1016/j.athoracsur.2010.07.112
   Ross JJ, 2004, MEDICINE, V83, P139, DOI 10.1097/01.md.0000126761.83417.29
   Schipper P, 2017, THORAC SURG CLIN, V27, P73, DOI 10.1016/j.thorsurg.2017.01.001
   Schreiner W, 2013, ZBL CHIR, V138, P117, DOI 10.1055/s-0032-1315201
   Schreiner W, 2018, PLAST AESTHET RES, V5, P32, DOI 10.20517/2347-9264.2018.45
   Singh D, 2017, WOUNDS, V29, P175
   Song HK, 2002, ANN THORAC SURG, V73, P427, DOI 10.1016/S0003-4975(01)03390-2
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
NR 20
TC 10
Z9 14
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD NOV
PY 2020
VL 110
IS 5
BP 1722
EP 1725
DI 10.1016/j.athoracsur.2020.04.037
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA OE6OH
UT WOS:000580647400076
PM 32497648
OA Bronze
DA 2026-07-24
ER
PT J
AU Baek, W
   Lee, N
   Han, EJ
   Roh, TS
   Lee, WJ
AF Baek, Wooyeol
   Lee, Nara
   Han, Eun Jin
   Roh, Tai Suk
   Lee, Won Jai
TI A Prospective Randomized Study: The Usefulness and Efficacy of Negative
   Pressure Wound Therapy with Lipidocolloid Polyester Mesh Compared to
   Traditional Negative Pressure Wound Therapy for Treatment of Pressure
   Ulcers
SO PHARMACEUTICS
LA English
DT Article
DE pressure ulcer; negative pressure wound therapy; wound contact layer;
   Urgotul(R)
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTION; IMPACT
AB To improve healing of pressure ulcer wounds, it is important to optimize the conditions of the area surrounding the wound. Negative pressure wound therapy (NPWT) promotes wound healing, however, the removal of NPWT can cause pain or focal bleeding, delaying wound healing or causing infection. In this study, we reviewed the efficacy of the lipidocolloid non-adherent dressing (Urgotul(R)) as a wound contact layer. A total of 38 patients from the same facility who applied NPWT from April 2016 to October 2019 were included and divided into two groups; NPWT with the lipidocolloid non-adherent dressing (group 1, experimental group, 19 patients) and NPWT only (group 2, control group, 19 patients). The condition of the wound was examined prior to NPWT application, at one week, and again at three weeks after application. No significant differences were found between groups for general characteristics, bacterial culture or photo analysis. However, when comparing groups based on the time of examination, there was a significant reduction of the wound size in group 1 (p= 0.001) but not in group 2 (p= 0.082). Therefore, the current study finds that using the lipidocolloid non-adherent dressing as a wound contact layer in NPWT stimulates healing by shrinking the size of the pressure ulcer wound.
C1 [Baek, Wooyeol; Lee, Nara; Roh, Tai Suk; Lee, Won Jai] Yonsei Univ, Severance Hosp, Inst Human Tissue Restorat, Dept Plast & Reconstruct Surg,Coll Med, Seoul 03722, South Korea.
   [Han, Eun Jin] Severance Hosp, Nurse Dept, Certified Wound Care Nurse CWCN, Certified Foot Care Nurse CFCN, Seoul 03722, South Korea.
C3 Yonsei University; Yonsei University Health System; Severance Hospital;
   Yonsei University; Severance Hospital
RP Lee, WJ (通讯作者)，Yonsei Univ, Severance Hosp, Inst Human Tissue Restorat, Dept Plast & Reconstruct Surg,Coll Med, Seoul 03722, South Korea.
EM laquaglm@mskcc.org; nrlee@yuhs.ac; ejhan84@yuhs.ac; rohts@yuhs.ac;
   pswjlee@yuhs.ac
RI roh, tai suk/W-3044-2019
OI roh, tai suk/0000-0001-8681-159X; won jai, lee/0000-0003-3056-0503; Lee,
   Nara/0000-0002-6563-1888
FU JW pharmaceutical [1-2015-0094]
FX This work was supported by a grant from JW pharmaceutical.
   (1-2015-0094).
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NR 19
TC 7
Z9 9
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD SEP
PY 2020
VL 12
IS 9
AR 813
DI 10.3390/pharmaceutics12090813
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OE8JD
UT WOS:000580769200001
PM 32867251
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ciudad, P
   Vargas, MI
   Castillo-Soto, A
   Sanchez, JR
   Manrique, OJ
   Bustos, SS
   Forte, AJ
   Huayllani, MT
   Soto, Z
   Grández-Urbina, JA
AF Ciudad, Pedro
   Vargas, Maria I.
   Castillo-Soto, Ana
   Sanchez, Jefferson R.
   Manrique, Oscar J.
   Bustos, Samyd S.
   Forte, Antonio J.
   Huayllani, Maria T.
   Soto, Zoila
   Antonio Grandez-Urbina, J.
TI Microvascular free-flap reconstruction in acute hard-to-heal wounds
SO JOURNAL OF WOUND CARE
LA Spanish
DT Article
DE negative pressure wound therapy; hard-to-heal wounds; reconstruction;
   microvascular free flap
ID LOWER-LIMB INJURY; MICROSURGICAL RECONSTRUCTION; THERAPY; TRAUMA; LADDER
AB Objective: Present different flap alternatives when performing microvascular free-flap reconstruction in acute hard-to-heal wounds. Method: A retrospective review of patients whose acute hard-to-heal wounds were treated with microvascular free-flap reconstruction. Data on demographics, wound aetiology, diagnostic, previous treatment, free-flap type, free-flap size, complications and follow up were analysed. Results: A total of 20 patients received microvascular free-flap reconstruction. The median age was 39.5 years. Twenty free-flap reconstructions were performed. These included: 3 cross-leg free flap, 1 cross-leg vascular cable bridge flap, 2 fibula osteocutaneous flap, 6 anterolateral thigh (ALT) flap, 3 thoracodorsal artery perforator (TDAP) flap, 3 fasciomyocutaneous flap, and 2 femoral artery fasciocutaneous flap. A patient required microvascular anastomosis due to hematoma; the rest did not present complications during their postoperative. Previous treatment included negative pressure wound therapy (12 patients) and surgical debridement with silver hydrogel dressings (8 patients). Conclusion: Hard-to-heal wounds can be unresponsive to traditional wound healing practices or local flaps. They often require free-flap reconstruction, using tissues similar to those compromised. Microvascular techniques can be an effective alternative.
C1 [Ciudad, Pedro; Vargas, Maria I.] Hosp Nacl Arzobispo Loayza, Dept Cirugia Plast Reconstruct & Quemaduras, Lima, Peru.
   [Ciudad, Pedro] China Med Univ Hosp, Div Cirujia Plast, Taichung, Taiwan.
   [Castillo-Soto, Ana; Sanchez, Jefferson R.] Univ Peruana Ciencias Aplicadas, Fac Med, Lima, Peru.
   [Manrique, Oscar J.; Bustos, Samyd S.] Mayo Clin, Div Plast & Reconstruct Surg, Rochester, MN USA.
   [Forte, Antonio J.; Huayllani, Maria T.] Mayo Clin, Div Cirugia Plast & Reconstruct, Jacksonville, FL 32224 USA.
   [Soto, Zoila] Renacer Clin, Lima, Peru.
   [Antonio Grandez-Urbina, J.] Univ Continental, Lima, Peru.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; Universidad Peruana de Ciencias Aplicadas (UPC); Mayo Clinic;
   Mayo Clinic; Universidad Continental
RP Ciudad, P (通讯作者)，Hosp Nacl Arzobispo Loayza, Dept Cirugia Plast Reconstruct & Quemaduras, Lima, Peru.; Ciudad, P (通讯作者)，China Med Univ Hosp, Div Cirujia Plast, Taichung, Taiwan.
EM pciudad@hotmail.com
RI Bustos, Samyd/AAW-2029-2020; Forte, Antonio Jorge/I-2970-2019;
   Grandez-Urbina, J. Antonio/PNF-5974-2026
OI Bustos, Samyd/0000-0003-2907-1067; Forte, Antonio
   Jorge/0000-0003-2004-7538; 
CR Beris AE, 2011, MICROSURG, V31, P205, DOI 10.1002/micr.20841
   Chan JKK, 2012, PLAST RECONSTR SURG, V130, p284E, DOI 10.1097/PRS.0b013e3182589e63
   Consenso Internacional, 2012, US AD AP PLAT HER CO
   Costa ML, 2018, HEALTH TECHNOL ASSES, V22, P1, DOI 10.3310/hta22730
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   Williams G, 2015, ORTHOPAEDIC P, V97-B, P77, DOI [10.1302/1358-992X.97BSUPP_15.EBJIS2015-077, DOI 10.1302/1358-992X.97BSUPP_15.EBJIS2015-077]
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NR 31
TC 2
Z9 2
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2020
VL 29
IS 10
SU 1
BP 27
EP 34
DI 10.12968/jowc.2020.29.LatAm_sup_2.27
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA OF0AU
UT WOS:000580883100003
PM 33054617
DA 2026-07-24
ER
PT J
AU Gheuens, L
   Roggeman, Q
   Cortebeeck, K
   Leyman, P
   Bernaerts, A
   De Foer, B
   Van Leemput, J
   van Dinther, J
AF Gheuens, Lisa
   Roggeman, Quinten
   Cortebeeck, Koen
   Leyman, Paul
   Bernaerts, Anja
   De Foer, Bert
   Van Leemput, Jan
   van Dinther, Joost
TI Pediatric necrotizing soft tissue infection after elective surgery: A
   case report and literature review
SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
LA English
DT Review
DE Necrotizing soft tissue infections; Pediatric; Head and neck surgery;
   Surgical debridement
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; NEGATIVE-PRESSURE;
   FASCIITIS; MANAGEMENT; DIAGNOSIS; CHILDREN; HEAD
AB Introduction: Necrotizing soft tissue infections (NSTIs) are rare but often lethal. Early diagnosis and aggressive surgical debridement are essential to achieve the best possible outcome.
   Case presentation: A 12-year old boy was diagnosed with a necrotizing soft tissue infection following elective revision surgery for functional impairment resulting from scar tissue of the neck. Fever and inflammation of the surgical wound manifested 24-36 hours postoperatively. Antibiotic therapy with amoxicillin-clavulanic acid was initiated, but the patient was unresponsive. Ultrasonography, a wound culture and surgical exploration confirmed the diagnosis. The culture was positive for a Streptococcus pyogenes infection and antibiotic treatment was switched to penicillin and clindamycin. Following the diagnosis, surgical debridement was performed subcutaneously, and only necrotic tissue was removed to preserve as much skin tissue as possible. After eradication of the infection, vacuum-assisted closure of the wound was used to close the subcutaneous space. The patient was discharged after 40 days.
   Conclusion: In this patient, we treated a necrotizing soft tissue infection with antibiotics, skin sparing surgeries and negative pressure wound therapy (NPWT). We used ultrasonography as imaging technique to help with the diagnosis. The extensiveness of surgical debridement was rather limited. We focused on opening all affected fascial layers. The surgical debridement was subcutaneous, and only necrotic tissue was removed. Because of the location in the neck, we tried to avoid an aggressive skin debridement to preserve as much skin tissue as possible. Negative pressure wound therapy is not frequently used in this context but it contributed to an enhanced wound healing. Ultrasonography for diagnosing NSTIs is useful, but the clinical findings and an explorative surgery will remain most important.
C1 [Gheuens, Lisa; Roggeman, Quinten; van Dinther, Joost] GZA Hosp, Dept ENT HNS, European Inst ORL HNS, Campus Sint Augustinus, Antwerp, Belgium.
   [Cortebeeck, Koen] GZA Hosp, Wound Care Unit, Campus Sint Augustinus, Antwerp, Belgium.
   [Leyman, Paul] GZA Hosp, Div Neonatal & Pediat Surg, Dept Gen & Digest Surg, Campus Sint Augustinus, Antwerp, Belgium.
   [Bernaerts, Anja; De Foer, Bert] GZA Hosp, Dept Radiol, Campus Sint Augustinus, Antwerp, Belgium.
   [Van Leemput, Jan] GZA Hosp, Intens Care Unit, Campus Sint Augustinus, Antwerp, Belgium.
RP Gheuens, L (通讯作者)，GZA Hosp, Dept ENT HNS, European Inst ORL HNS, Campus Sint Augustinus, Antwerp, Belgium.
EM Lisa.gheuens@uzgent.be
CR Anaya DA, 2007, CLIN INFECT DIS, V44, P705, DOI 10.1086/511638
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   Boo YJ, 2015, BMC PEDIATR, V15, DOI 10.1186/s12887-015-0352-5
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NR 37
TC 4
Z9 5
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-5876
EI 1872-8464
J9 INT J PEDIATR OTORHI
JI Int. J. Pediatr. Otorhinolaryngol.
PD NOV
PY 2020
VL 138
AR 110195
DI 10.1016/j.ijporl.2020.110195
PG 6
WC Otorhinolaryngology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Pediatrics
GA OF4ID
UT WOS:000581172700008
PM 32705989
DA 2026-07-24
ER
PT J
AU Cirocchi, R
   Popivanov, G
   Konaktchieva, M
   Chipeva, S
   Tellan, G
   Mingoli, A
   Zago, M
   Chiarugi, M
   Binda, GA
   Kafka, R
   Anania, G
   Donini, A
   Nascimbeni, R
   Edilbe, M
   Afshar, S
AF Cirocchi, Roberto
   Popivanov, Georgi
   Konaktchieva, Marina
   Chipeva, Sonia
   Tellan, Guglielmo
   Mingoli, Andrea
   Zago, Mauro
   Chiarugi, Massimo
   Binda, Gian Andrea
   Kafka, Reinhold
   Anania, Gabriele
   Donini, Annibale
   Nascimbeni, Riccardo
   Edilbe, Mohammed
   Afshar, Sorena
TI The role of damage control surgery in the treatment of perforated
   colonic diverticulitis: a systematic review and meta-analysis
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Review
DE Diverticular perforation; Diverticular peritonitis; Damage control
   surgery
ID HARTMANNS PROCEDURE; PRIMARY ANASTOMOSIS; GENERALIZED PERITONITIS;
   CONTROL STRATEGY; TRAUMA PATIENTS; MANAGEMENT; REVERSAL; MORTALITY;
   RESECTION; SURVIVAL
AB Introduction Damage control surgery (DCS) is the classic approach to manage severe trauma and has recently also been considered an appropriate approach to the treatment of critically ill patients with severe intra-abdominal sepsis. The purpose of the present review is to evaluate the outcomes following DCS for Hinchey II-IV complicated acute diverticulitis (CAD). Methods A comprehensive systematic search was undertaken to identify all randomized clinical trials (RCTs) and observational studies, irrespectively of their size, publication status, and language. Adults who have undergone DCS for CAD Hinchey II, III, or IV were included in this review. DCS is compared with the immediate and definitive surgical treatment in the form of HP, colonic resection, and primary anastomosis (RPA) with or without covering stoma or laparoscopic lavage. We searched the following electronic databases: PubMed MEDLINE, Scopus, and ISI Web of Knowledge. The protocol of this systematic review and meta-analysis was published on Prospero (CRD42020144953). Results Nine studies with 318 patients, undergoing DCS, were included. The presence of septic shock at the presentation in the emergency department was heterogeneous, and the weighted mean rate of septic shock across the studies was shown to be 35.1% [95% CI 8.4 to 78.6%]. The majority of the patients had Hinchey III (68.3%) disease. The remainder had either Hinchey IV (28.9%) or Hinchey II (2.8%). Phase I is similarly described in most of the studies as lavage, limited resection with closed blind colonic ends. In a few studies, resection and anastomosis (9.1%) or suture of the perforation site (0.9%) were performed in phase I of DCS. In those patients who underwent DCS, the most common method of temporary abdominal closure (TAC) was the negative pressure wound therapy (NPWT) (97.8%). The RPA was performed in 62.1% [95% CI 40.8 to 83.3%] and the 22.7% [95% CI 15.1 to 30.3%]: 12.8% during phase I and 87.2% during phase III. A covering ileostomy was performed in 6.9% [95% CI 1.5 to 12.2%]. In patients with RPA, the overall leak was 7.3% [95% CI 4.3 to 10.4%] and the major anastomotic leaks were 4.7% [95% CI 2.0 to 7.4%]; the rate of postoperative mortality was estimated to be 9.2% [95% CI 6.0 to 12.4%]. Conclusions The present meta-analysis revealed an approximately 62.1% weighted rate of achieving GI continuity with the DCS approach to generalized peritonitis in Hinchey III and IV with major leaks of 4.7% and overall mortality of 9.2%. Despite the promising results, we are aware of the limitations related to the significant heterogeneity of inclusion criteria. Importantly, the low rate of reported septic shock may point toward selection bias. Further studies are needed to evaluate the clinical advantages and cost-effectiveness of the DCS approach.
C1 [Cirocchi, Roberto; Donini, Annibale] Univ Perugia, Dept Gen Surg, I-06123 Perugia, Italy.
   [Popivanov, Georgi] Mil Med Acad, Dept Surg, Ul Sv Georgi Sofiyski 3, Sofia 1606, Bulgaria.
   [Konaktchieva, Marina] Mil Med Acad, Dept Gastroenterol & Hepatol, Ul Sv Georgi Sofiyski 3, Sofia 1606, Bulgaria.
   [Chipeva, Sonia] Univ Natl & World Econ, Dept Stat & Econometr, Sofia, Bulgaria.
   [Tellan, Guglielmo] Sapienza Univ Rome, Umberto I Univ Hosp, Dept Emergency & Acceptance, Crit Areas & Trauma, I-00161 Rome, Italy.
   [Mingoli, Andrea] Sapienza Univ Roma, Dipartimento Chirurg P Valdoni, Viale Policlin 155, I-00161 Rome, Italy.
   [Zago, Mauro] A Manzoni Hosp, Dept Emergency & Robot Surg, Lecce, Italy.
   [Chiarugi, Massimo] Cisanello Univ Hosp, Emergency Surg & Trauma Ctr, I-56124 Pisa, Italy.
   [Binda, Gian Andrea] Biomed Inst, Colorectal Surg, I-16157 Genoa, Italy.
   [Kafka, Reinhold] Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria.
   [Anania, Gabriele] Univ Ferrara, Dept Med Sci, I-4121 Ferrara, Italy.
   [Nascimbeni, Riccardo] Univ Brescia, Dept Mol & Translat Med, I-25121 Brescia, Italy.
   [Edilbe, Mohammed; Afshar, Sorena] North Cumbria Integrated Care NHS Fdn Trust, Carlisle, England.
C3 University of Perugia; Military Medical Academy Sofia; Military Medical
   Academy Sofia; University of National & World Economics - Bulgaria;
   Sapienza University Rome; University Hospital Sapienza Rome; Sapienza
   University Rome; Medical University of Innsbruck; University of Ferrara;
   University of Brescia
RP Cirocchi, R (通讯作者)，Univ Perugia, Dept Gen Surg, I-06123 Perugia, Italy.
EM roberto.cirocchi@unipg.it; gerasimpopivanov@rocketmail.com;
   marina.konaktchieva@yahoo.com; sonia.chipeva@hotmail.com;
   guglielmo.tellan@uniroma1.it; andrea.mingoli@uniroma1.it;
   maurozago.md@gmail.com; massimo.chiarugi@med.unipi.it;
   gianbinda1@gmail.com; reinhold.kafka-ritsch@tirol-kliniken.at;
   g.anania@unife.it; annibale.donini@unipg.it;
   riccardo.nascimbeni@unibs.it; mwedilbe@outlook.com;
   s.afshar@doctors.org.uk
RI Mingoli, Andrea/A-2889-2010; Zago, Matteo/B-1481-2015; Popivanov,
   Georgi/IVH-4670-2023; Cirocchi, Roberto/I-1197-2014; Chiarugi,
   Massimo/ABQ-7280-2022
OI Chiarugi, Massimo/0000-0001-6905-2499; TELLAN,
   GUGLIELMO/0000-0002-4129-3300
FU Universita degli Studi di Perugia within the CRUI-CARE Agreement
FX Open access funding provided by Universita degli Studi di Perugia within
   the CRUI-CARE Agreement.
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NR 67
TC 31
Z9 32
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD MAY
PY 2021
VL 36
IS 5
BP 867
EP 879
DI 10.1007/s00384-020-03784-8
EA OCT 2020
PG 13
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA RJ7VP
UT WOS:000581831900001
PM 33089382
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Fukushima, S
   Komune, N
   Kamizono, K
   Matsumoto, N
   Takaiwa, K
   Nakagawa, T
   Kadota, H
AF Fukushima, Seita
   Komune, Noritaka
   Kamizono, Kenichi
   Matsumoto, Nozomu
   Takaiwa, Kazutaka
   Nakagawa, Takashi
   Kadota, Hideki
TI Use of negative pressure wound therapy to treat a cochlear implant
   infection around the auricle: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE auricle; cochlear implant; head and neck; negative pressure wound
   therapy; wound management
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; HEAD
AB Although negative pressure wound therapy (NPWT) is widely used, its application to the head and neck region remains challenging due to anatomical complexities. This report presents the case of a female patient presenting with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes, uncontrolled diabetes and severe bilateral sensorineural hearing loss. The patient had undergone cochlear implant surgery and five months later the wound was infected with methicillin-resistant Staphylococcus aureus (MRSA). NPWT was started shortly after removing the internal receiver and was stopped 11 days later. NPWT helped in controlling infection and led to a successful wound closure. In this case, NPWT was effective in treating infectious wounds around the auricle after cochlear implant surgery.
C1 [Fukushima, Seita; Komune, Noritaka; Kamizono, Kenichi; Matsumoto, Nozomu; Nakagawa, Takashi] Kyushu Univ, Grad Sch Med Sci, Dept Otorhinolaryngol, Fukuoka, Japan.
   [Fukushima, Seita; Kamizono, Kenichi; Kadota, Hideki] Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, Fukuoka, Japan.
   [Takaiwa, Kazutaka] Fukuoka Univ, Grad Sch Med Sci, Dept Otorhinolaryngol, Fukuoka, Japan.
C3 Kyushu University; Kyushu University; Fukuoka University
RP Komune, N (通讯作者)，Kyushu Univ, Grad Sch Med Sci, Dept Otorhinolaryngol, Fukuoka, Japan.
EM norikomu007@gmail.com
RI /AAU-7710-2020
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NR 14
TC 2
Z9 3
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2020
VL 29
IS 10
BP 568
EP 571
DI 10.12968/jowc.2020.29.10.568
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA OG7KI
UT WOS:000582057900014
PM 33052790
DA 2026-07-24
ER
PT J
AU Bayer, N
   Hart, WM
   Arulampalam, T
   Hamilton, C
   Schmoeckel, M
AF Bayer, Nicolai
   Hart, Warren Mark
   Arulampalam, Tan
   Hamilton, Colette
   Schmoeckel, Michael
TI Is the Use of BIMA in CABG Sub-Optimal? A Review of the Current Clinical
   and Economic Evidence Including Innovative Approaches to the Management
   of Mediastinitis
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Review
DE CABG; mediastinitis; bilateral; outcomes; costs
ID INTERNAL-THORACIC-ARTERY; STERNAL WOUND-INFECTION; CORONARY-BYPASS
   SURGERY; RISK-FACTORS; DIABETIC-PATIENTS; LONG-TERM; PREVENTION; GRAFTS;
   REVASCULARIZATION; METAANALYSIS
AB Bilateral internal mammary artery (BIMA) in coronary artery bypass grafting (CABG) has traditionally been limited. This review looks at the recent outcome data on BIMA in CABG focusing on the management of risk factors for mediastinitis, one of the potential barriers for more extensive BIMA utilization. A combination of pre-, intra- and postoperative strategies are essential to reduce mediastinitis. Limited data indicate that the incidence of mediastinitis can be reduced using closed incision negative-pressure wound therapy as a part of these strategies with the possibility of offering patients best treatment options by extending BIMA to those with a higher risk of mediastinitis. Recent economic data imply that the technology may challenge the current low uptake of BIMA by reducing the short-term cost differentials between single internal mammary artery and BIMA. Given that most published randomized controlled trials and meta-analyses of observational long-term outcome data favor BIMA, if short-term complications of BIMA including mediastinitis can be controlled adequately, there may be opportunities for more extensive use of BIMA leading to improved long-term outcomes. An ongoing study looking at BIMA in high-risk patients may provide evidence to support the hypothesis that mediastinitis should not be a factor in limiting the use of BIMA in CABG.
C1 [Bayer, Nicolai; Schmoeckel, Michael] Asklepios Klin St Georg, Hamburg, Germany.
   [Hart, Warren Mark; Arulampalam, Tan; Hamilton, Colette] Genesyze, Manchester, Lancs, England.
C3 Asklepios Klinik St. Georg
RP Hart, WM (通讯作者)，Genesyze, iHub, 13th Floor,City Tower,Piccadilly Plaza, Manchester M1 4BT, Lancs, England.
EM warren@genesyze.com
FU Smith Nephew
FX NB and MS are employees of Asklepios Klinik St Georg where the ongoing
   observational mediastinitis study, supported by Smith &Nephew, is being
   carried out; WMH serves as a consultant for Genesyze; and TA and CH are
   directors of Genesyze.
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NR 85
TC 9
Z9 12
U1 0
U2 1
PU Int Acad Publishing Co Ltd
PI Tokyo
PA Academy center, 358-5 yamabukicho, shinjuku-ku, Tokyo, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2020
VL 26
IS 5
BP 229
EP 239
DI 10.5761/atcs.ra.19-00310
PG 11
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA OI2JB
UT WOS:000583110400001
PM 32921659
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, GW
   Duan, GX
   Li, CK
   Tao, T
   Wang, KW
   Zong, CC
   Wang, ZY
AF Wang, Guowen
   Duan, Guixin
   Li, Chuankui
   Tao, Tao
   Wang, Kangwu
   Zong, Chengcheng
   Wang, Zuyi
TI Experiences in the diagnosis and treatment of postoperative
   esophagopleural sac fistula
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Esophagectomy; anastomotic fistula; esophageal cancer; esophageal
   perforation
ID INTRATHORACIC ANASTOMOTIC LEAK; VACUUM-ASSISTED CLOSURE; CONTRAST
   SWALLOW; ESOPHAGECTOMY; MANAGEMENT; STENT; CT; COMPLICATIONS; PLACEMENT;
   RESECTION
AB Esophagopleural sac fistula is a rare complication of esophagectomy associated with a relatively high mortality rate. To examine the diagnosis and treatment of esophago-mediastinal/pleural sac fistulas, 6 cases of esophago-mediastinal/pleural fistula of different etiologies, with a critical appraisal of current domestic and international clinical research, were analyzed. Our six patients were recovered and discharged from the hospital. Although contrast abdominal computed tomography, using a water-soluble contrast medium, and endoscopy can be used for the diagnosis of esophago-mediastinal/pleural sac fistulas in specific patients, observation of clinical symptoms remains the most important criterion for diagnosis. A standardized evaluation of specific issues is recommended for all patients to effectively determine the need for re-thoracotomy. Stent implantation under endoscopy should be avoided unless absolutely necessary. However, vacuum sealing and drainage of a transesophageal anastomotic stoma can facilitate healing of a leak. Pleural lavage can be used, when necessary, to relieve clinical symptoms and, again, facilitate healing of a leak. Moreover, maintaining intact pleura on the pleural cupula can reduce the risk of a cervical anastomotic fistula from spreading into the chest cavity.
C1 [Wang, Guowen; Duan, Guixin; Li, Chuankui; Tao, Tao; Wang, Kangwu; Zong, Chengcheng; Wang, Zuyi] Bengbu Med Coll, Dept Thorac Surg, Affiliated Hosp 1, 287 Zhihuai Rd, Bengbu 233004, Anhui, Peoples R China.
C3 Bengbu Medical University
RP Wang, ZY (通讯作者)，Bengbu Med Coll, Dept Thorac Surg, Affiliated Hosp 1, 287 Zhihuai Rd, Bengbu 233004, Anhui, Peoples R China.
EM wgwpc1@126.com
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NR 54
TC 0
Z9 0
U1 0
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2020
VL 13
IS 10
BP 8175
EP 8193
PG 19
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA OL2QD
UT WOS:000585185700122
DA 2026-07-24
ER
PT J
AU Al Majid, FM
   Buba, FM
   Barry, M
   Alsharani, F
   Alfawzan, F
AF Al Majid, Fahad M.
   Buba, Faruk M.
   Barry, Mazen
   Alsharani, Fatima
   Alfawzan, Fawzan
TI Incidence, types and outcomes of sternal wound infections after cardiac
   surgery in Saudi Arabia A retrospective medical chart review
SO SAUDI MEDICAL JOURNAL
LA English
DT Review
DE surgical wound infection; sternotomy; risk factors; outcomes
ID SURGICAL-SITE INFECTION; ARTERY-BYPASS GRAFT; RISK-FACTORS;
   ANTIBIOTIC-PROPHYLAXIS; COMPLICATIONS; MEDIASTINITIS; MANAGEMENT
AB Objectives: To determine the incidence, types, risk factors, identify organisms, and assess outcomes of surgical wound infections (SWIs) after cardiac surgery at a tertiary hospital in Riyadh, Saudi Arabia.
   Methods: This historical cohort study reviewed the chart of patients who underwent cardiac surgery at King Khalid University Hospital, Riyadh, Saudi Arabia between January 2009 and December 2014. The proforma contained personal data, comorbidities, type of surgery, microbiological analysis, and management outcomes.
   Results: A total of 1241 patients were enrolled in the study comprising 1,032 (83.2%) men and 209 (16.8%) women. Forty (3.2%) patients developed SWI, of which 32 (2.5%) were superficial and 8 (0.7%) were deep. Gender, obesity, diabetes mellitus, non-use of statins, and coronary artery bypass graft (CABG) surgery were not significant predictors of infection in the study. Methicillin-susceptible Staphylococcus aureus was isolated predominantly in 45%, followed by Klebsiella and Pseudomonas species. Methicillin-resistant Staphylococcus aureus, Enterococcus faecium, and extended beta-lactamase-producing gram-negative organisms were pathogens isolated in last 3 years of the review. Simple and vacuum assisted closure therapies led to complete resolution in 32 (80%) patients, while 8 (20%) developed sternal osteomyelitis. All patients survived except one with a deep SWI who died of uncontrolled sepsis.
   Conclusion: Despite the low incidence of postoperative SWIs, the risk of sternal osteomyelitis development persists. Meticulous choice of CABG components and appropriate postoperative management, especially detecting early signs of SWI could contribute to lower its incidence and complications.
C1 [Al Majid, Fahad M.; Barry, Mazen; Alsharani, Fatima] King Saudi Univ, Dept Infect Dis, Riyadh, Saudi Arabia.
   [Alfawzan, Fawzan] King Khalid Univ Hosp, Dept Med, Riyadh, Saudi Arabia.
   [Buba, Faruk M.] Univ Maiduguri, Coll Med Sci, Dept Med, Maiduguri, Nigeria.
C3 King Saud University; King Khalid University Hospital
RP Al Majid, FM (通讯作者)，King Saudi Univ, Dept Infect Dis, Riyadh, Saudi Arabia.
EM falmajid@gmail.com
RI Barry, Mazin/AAJ-7615-2020
OI Barry, Mazin/0000-0003-2274-007X; alshahrani,
   fatimah/0000-0002-4646-7488
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NR 32
TC 11
Z9 14
U1 0
U2 0
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
EI 1658-3175
J9 SAUDI MED J
JI Saudi Med. J.
PD FEB
PY 2020
VL 41
IS 2
BP 177
EP 182
DI 10.15537/smj.2020.2.24843
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OL3QU
UT WOS:000585258200010
PM 32020152
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sandy-Hodgetts, K
   Parsons, R
   Norman, R
   Fear, MW
   Wood, FM
   White, SW
AF Sandy-Hodgetts, Kylie
   Parsons, Richard
   Norman, Richard
   Fear, Mark W.
   Wood, Fiona M.
   White, Scott W.
TI Effectiveness of negative pressure wound therapy in the prevention of
   surgical wound complications in the cesarean section at-risk population:
   a parallel group randomised multicentre trial-the CYGNUS protocol
SO BMJ OPEN
LA English
DT Article
DE wound management; surgery; obstetrics; clinical trials
ID CLINICAL-TRIALS; DELIVERY; PATIENT
AB Introduction Caesarean delivery is steadily becoming one of the more common surgical procedures in Australia with over 100 000 caesarean sections performed each year. Over the last 10 years in Australia, the caesarean section rate has increased from 28% in 2003 to 33% in 2013. On the international stage, the Australian caesarean delivery rates are higher than the average for the Organisation for Economic Co-operation and Development, Australia ranked as 8 out of 33 and is second to the USA. Postoperative surgical site infections (SSIs) and wound complications are the most common and costly event following a caesarean section. Globally, complication rates following a caesarean delivery vary from 4.9% to 9.8%. Complications such as infection and wound breakdown affect the postpartum mother's health and well-being, and contribute to healthcare costs for clinical management that often spans the acute, community and primary healthcare settings. Published level one studies using advanced wound dressings in the identified 'at-risk' population prior to surgery for prophylactic intervention are yet to be forthcoming. Methods and analysis A parallel group randomised control trial of 448 patients will be conducted across two metropolitan hospitals in Perth, Western Australia, which provide obstetric and midwifery services. We will recruit pregnant women in the last trimester, prior to their admission into the healthcare facility for delivery of their child. We will use a computer-generated block sequence to randomise the 448 participants to either the interventional (negative pressure wound therapy (NPWT) dressing, n=224) or comparator arm (non-NPWT dressing, n=224). The primary outcome measure is the occurrence of surgical wound dehiscence (SSWD) or SSI. The Centres for Disease Control reporting definition of either superficial or deep infection at 30 days will be used as the outcome measure definition. SWD will be classified as per the World Union of Wound Healing Societies grading system (grade I-IV). We will assess recruitment rate, and adherence to intervention and follow-up. We will assess the potential effectiveness of NPWT in the prevention of postpartum surgical wound complications at three time points during the study; postoperative days 5, 14 and 30, after which the participant will be closed out of the trial. We will use statistical methods to determine efficacy, and risk stratification will be conducted to determine the SWD risk profile of the participant. Follow-up at day 30 will assess superficial and deep infection, and wound dehiscence (grade I-IV) and the core outcome data set for wound complications. This study will collect health-related quality of life (European Quality of Life 5-Dimensions 5-Level Scale), mortality and late complications such as further surgery with a cost analysis conducted. The primary analysis will be by intention-to-treat. This clinical trial protocol follows the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) and the Consolidated Standards of Reporting Trials guidelines. Ethics and dissemination Ethics approval was obtained through St John of God Health Care (HREC1409), Western Australia Department of Health King Edward Memorial Hospital (HREC3111). Study findings will be published in peer-reviewed journals and presented at international conferences. We used the SPIRIT checklist when writing our study protocol.
C1 [Sandy-Hodgetts, Kylie] Univ Western Australia, Sch Biomed Sci, Skin Integr Res Inst, Crawley, WA, Australia.
   [Parsons, Richard] Curtin Univ, Fac Hlth Sci, Sch Occupat Therapy Social Work & Speech Pathol, Perth, WA, Australia.
   [Norman, Richard] Curtin Univ, Fac Hlth Sci, Sch Publ Hlth, Perth, WA, Australia.
   [Fear, Mark W.] Univ Western Australia, Sch Biomed Sci, Burn Injury Res Unit, Crawley, WA, Australia.
   [Wood, Fiona M.] Fiona Stanley Hosp, Burns Serv Western Australia, Perth, WA, Australia.
   [Wood, Fiona M.] Princess Margaret Hosp, Burns Serv Western Australia, Perth, WA, Australia.
   [White, Scott W.] Univ Western Australia, Fac Hlth & Med Sci, Dept Obstet & Gynaecol, Perth, WA, Australia.
   [White, Scott W.] King Edward Mem Hosp, Maternal Fetal Med Serv, Subiaco, WA, Australia.
C3 University of Western Australia; Curtin University; Curtin University;
   University of Western Australia; South Metropolitan Health Service;
   Fiona Stanley Fremantle Hospitals Group; Fiona Stanley Hospital; Perth
   Childrens Hospital; University of Western Australia; University of
   Western Australia; University of Western Australia; King Edward Memorial
   Hospital
RP Sandy-Hodgetts, K (通讯作者)，Univ Western Australia, Sch Biomed Sci, Skin Integr Res Inst, Crawley, WA, Australia.
EM kylie.sandy-hodgetts@uwa.edu.au
RI Sandy-Hodgetts, Kylie/A-7494-2019; fiona, wood/F-4703-2013; fear,
   mark/H-9170-2014
OI Sandy-Hodgetts, Kylie/0000-0001-6848-2526; fiona,
   wood/0000-0001-5427-6588; fear, mark/0000-0003-3163-4666; White,
   Scott/0000-0002-7235-6407
FU ConvaTec [UWA52001100]
FX This work is funded by an unrestricted educational grant from ConvaTec.
   Grant ID UWA52001100.
CR ACSQH, 2017, NAT SAF QUAL HLTH SE, V2nd
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NR 24
TC 4
Z9 5
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 10
AR e035727
DI 10.1136/bmjopen-2019-035727
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OM0SA
UT WOS:000585738900003
PM 33077559
OA Green Submitted, Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Wierdak, M
   Pisarska-Adamczyk, M
   Wysocki, M
   Major, P
   Kolodziejska, K
   Nowakowski, M
   Vongsurbchart, T
   Pedziwiatr, M
AF Wierdak, M.
   Pisarska-Adamczyk, M.
   Wysocki, M.
   Major, P.
   Kolodziejska, K.
   Nowakowski, M.
   Vongsurbchart, T.
   Pedziwiatr, M.
TI Prophylactic negative-pressure wound therapy after ileostomy reversal
   for the prevention of wound healing complications in colorectal cancer
   patients: a randomized controlled trial
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE Prophylactic negative pressure wound therapy; Ileostomy closure;
   Prevention of wound-related complications; Colorectal cancer operation;
   Randomized controlled trial
ID SURGICAL SITE INFECTION; LOW ANTERIOR RESECTION; RECTAL-CANCER; CLOSURE;
   METAANALYSIS; OUTCOMES
AB Background The aim of this study was to assess the usefulness of protective negative-pressure wound therapy (NPWT) in the reduction of wound healing complications (WHC) and surgical site infections (SSI) after diverting ileostomy closure in patients who underwent surgery for colorectal cancer. Methods In this prospective randomized clinical trial in a tertiary academic surgical center, patients who had colorectal cancer surgery with protective loop ileostomy and were scheduled to undergo ileostomy closure with primary wound closure from January 2016 to December 2018 were randomized to be treated with or without NPWT. The primary endpoint was the incidence of WHC. Secondary endpoints were incidence of SSI, length of postoperative hospital stay (LOS), and length of complete wound healing (CWH) time. Results We enrolled 35 patients NPWT (24 males [68.6%]; mean age 61.6 +/- 11.3 years), with NPWT and 36 patients (20 males [55.6%]; mean age 62.4 +/- 11.3 years) with only primary wound closure (control group). WHC was observed in 11 patients (30.6%) in the control group and 3 (8.57%) in the NPWT group (p = 0.020). Patients in the NPWT group had a significantly lower incidence of SSI (2 [5.71%] vs. 8 [22.2%] in the control group; p = 0.046) as well as significantly shorter median CWH (7 [7-7] days vs. 7 [7-15.5] days, p = 0.030). There was no difference in median LOS between groups (3 [2.5-5] days in the control group vs. 4 [2-4] days in the NPWT group; p = 0.072). Conclusions Prophylactic postoperative NPWT after diverting ileostomy closure in colorectal cancer patients reduces the incidence of WRC and SSI.
C1 [Wierdak, M.; Pisarska-Adamczyk, M.; Wysocki, M.; Major, P.; Kolodziejska, K.; Nowakowski, M.; Vongsurbchart, T.; Pedziwiatr, M.] Jagiellonian Univ Med Coll, Dept Gen Surg 2, Jakubowskiego 2 Str, PL-30688 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University
RP Wysocki, M (通讯作者)，Jagiellonian Univ Med Coll, Dept Gen Surg 2, Jakubowskiego 2 Str, PL-30688 Krakow, Poland.
EM mateusz.wierdak@uj.edu.pl; magdalena.pisarska@doctoral.uj.edu.pl;
   m.wysocki@doctoral.uj.edu.pl; piotr.major@uj.edu.pl;
   kat.truszkiewicz@gmail.com; m.nowakowski@uj.edu.pl;
   tanawatv19@gmail.com; michal.pedziwiatr@uj.edu.pl
RI Nowakowski, Michal/HTT-3696-2023; Pedziwiatr, Michal/B-1594-2016;
   Pisarska-Adamczyk, Magdalena/ABD-7785-2020
FU Jagiellonian University Medical College; NPWT equipment producers
FX This research was financed only by the Jagiellonian University Medical
   College own funds, without any financial or material support from the
   NPWT equipment producers.
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NR 21
TC 39
Z9 46
U1 0
U2 5
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD FEB
PY 2021
VL 25
IS 2
BP 185
EP 193
DI 10.1007/s10151-020-02372-w
EA NOV 2020
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA QH6IF
UT WOS:000587268600001
PM 33161523
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Asciutto, KC
   Acosta, S
   Borgfeldt, C
AF Asciutto, Katrin Christine
   Acosta, Stefan
   Borgfeldt, Christer
TI Negative Pressure Wound Therapy (NPWT) in Groin Wounds After
   Lymphadenectomy in Vulvar Cancer Patients
SO IN VIVO
LA English
DT Article
DE NPWT; lymphadenectomy groin; vulvar cancer
ID INGUINOFEMORAL LYMPHADENECTOMY; COMPLICATIONS; SURGERY; WOMEN;
   METAANALYSIS; VULVECTOMY; PREVENTION; MANAGEMENT; MORBIDITY; CARCINOMA
AB Background/Aim: Vulva cancer surgery is associated with a high level of morbidity mostly due to wound healing disorders in the inguinal region following lymphadenectomy. Our aim is to evaluate the feasibility of negative pressure wound therapy (NPWT) using the PICOT device in groin wounds after lymphadenectomy. Patients and Methods: The groins of twenty patients who underwent bilateral lymph node dissection were dressed with the PICOT device. All patients were followed prospectively with clinical controls up to three months postoperatively using a standardized study protocol. Results: A total of 11 patients (55%) developed a surgical site complication (SSC). One patient suffered from a wound rupture two days after surgery, six a lymphocele and four a surgical site infection. Operation time, blood loss, number of lymph nodes removed, length of hospital-stay and duration of PICOT treatment did not differ between women with and without SSCs. Conclusion: NPWT using the PICOT device seems to be a feasible method to reduce the severity of healing disorders in the groin after lymphadenectomy in vulva cancer patients.
C1 [Asciutto, Katrin Christine; Borgfeldt, Christer] Lund Unviv, Dept Obstet & Gynecol, Skane Univ Hosp, Lund, Sweden.
   [Acosta, Stefan] Lund Univ, Dept Clin Sci, Malmo, Sweden.
   [Acosta, Stefan] Skane Univ Hosp, Vasc Ctr, Malmo, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Lund
   University; Skane University Hospital
RP Asciutto, KC (通讯作者)，Skane Univ Hosp, Dept Obstet & Gynecol, Klinikgatan 12, SE-22185 Lund, Sweden.
EM christine.asciutto@yahoo.com
RI Acosta, Stefan/JAX-3225-2023; Borgfeldt, Christer/AHB-9589-2022
OI Acosta, Stefan/0000-0002-3225-0798; Borgfeldt,
   Christer/0000-0003-2267-8325; 
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NR 28
TC 6
Z9 8
U1 1
U2 5
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD NOV-DEC
PY 2020
VL 34
IS 6
BP 3511
EP 3517
DI 10.21873/invivo.12192
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA OP2QN
UT WOS:000587929100052
PM 33144461
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhang, N
   Yu, X
   Zhang, K
   Liu, TJ
AF Zhang, Nan
   Yu, Xin
   Zhang, Kai
   Liu, Tongjun
TI A retrospective case series of Fournier's gangrene: necrotizing
   fasciitis in perineum and perianal region
SO BMC SURGERY
LA English
DT Article
DE Fournier&#8217; s gangrene; Necrotizing fasciitis; Infection
ID LABORATORY RISK INDICATOR
AB Background To describe the clinical characteristics and management for Fournier's gangrene. Experience summary and literature references are provided for future treatment improvement. Methods We retrospectively reviewed the cases diagnosed with Fournier's gangrene in our department from June 2016 to June 2019. Clinical data, including manifestation, diagnosis, treatment and outcomes for Fournier's gangrene were presented. Results There were 12 patients enrolled in this paper, with the average age of 60 years old. It showed a male predominance with male-to-female ratio of 6:1. The average of laboratory risk indicator for necrotizing fasciitis (LRINEC) score was 10.1. Diabetes mellitus was the main predisposing disease. 11 patients received emergency debridement and 1 patient died of sepsis on the 2nd day after admission. The mortality rate was 8.3%. 6 cases developed complications, including sepsis, pneumonia, renal and heart failure. Negative pressure wound therapy (NPWT) was applied in 10 cases, while the rest 1 received normal daily dressing changes because of fecal contamination. Flaps were utilized in 2 patients to cover the defect, including one with advancement flap and one with pudendal-thigh flap, while others received secondary suture, secondary healing, skin graft or combined management. No relapse was observed during the follow-up visits. Conclusions Fournier's gangrene is a life-threatening infection that requires early diagnosis and surgery intervention. The predisposing disease, clinical manifestation and LRINEC score should be taken into comprehensive consideration, which is helpful for timely diagnosis. Moreover, further successful treatment depends on the aggressive debridement, broad-spectrum antibiotics therapy, wound management and closure choice.
C1 [Zhang, Nan; Zhang, Kai; Liu, Tongjun] Jilin Univ Second Hosp, Gen Surg, 218 ZiQiang St, Changchun 130000, Peoples R China.
   [Yu, Xin] Jilin Univ First Hosp, Dept Pediat, 71 Xinmin St, Changchun, Peoples R China.
RP Liu, TJ (通讯作者)，Jilin Univ Second Hosp, Gen Surg, 218 ZiQiang St, Changchun 130000, Peoples R China.
EM tongjunliu@sina.cn
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NR 21
TC 32
Z9 47
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD OCT 30
PY 2020
VL 20
IS 1
AR 259
DI 10.1186/s12893-020-00916-3
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OP3MR
UT WOS:000587986700001
PM 33126879
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chen, CY
   Chiang, IH
   Ou, KL
   Chiu, YL
   Liu, HH
   Chang, CK
   Wu, CJ
   Chu, TS
   Hsu, KF
   Huang, DW
   Tzeng, YS
AF Chen, Chun-Yu
   Chiang, I-Han
   Ou, Kuang-Ling
   Chiu, Yu-Lung
   Liu, Hung-Hui
   Chang, Chun-Kai
   Wu, Chien-Ju
   Chu, Tzi-Shiang
   Hsu, Kuo-Feng
   Huang, Dun-Wei
   Tzeng, Yuan-Sheng
TI Surgical treatment and strategy in patients with pressure sores A
   single-surgeon experience
SO MEDICINE
LA English
DT Article
DE surgical flaps; pressure sore; indocyanine green; negative-pressure
   wound therapy; vacuum-assisted closure
ID ARTERY PERFORATOR FLAP; RECONSTRUCTION; COVERAGE; ULCERS
AB With aging, pressure ulcers become a common health problem causing significant morbidity and mortality for physically limited or bedridden elderly persons. Here, we present our strategy for such patients. Between August 2010 and March 2019, 117 patients were enrolled. Patient age, etiology, defect size and location, flap reconstruction, outcome, and follow-up period were reviewed. Of these patients, 64 were female and 53 were male, with an age range of 21 to 96 years (mean 75.6). The mean area of defect was 61.5 cm(2). The most common etiology was dementia (33.3%), and ulcers were most frequently caused by sacral pressure (70.3%). The commonest surgical treatment was a V-Y advancement flap (50%). The complication rate was 27.5%, including dehiscence and late recurrence. Negative pressure wound therapy could be used if the initial defect was large. V-Y advancement flap is the most frequent surgical treatment for sacral pressure ulcers because it is simple and available for most types of defect. Primary closure may be considered as the simplest method if the defective area is <16 cm(2). Intraoperative indocyanine green angiography can help avoid secondary flap revisions. Our protocol ensures a short surgery time, little bleeding, and a low complication rate.
C1 [Chen, Chun-Yu; Chiang, I-Han; Ou, Kuang-Ling; Liu, Hung-Hui; Chang, Chun-Kai; Wu, Chien-Ju; Chu, Tzi-Shiang; Hsu, Kuo-Feng; Huang, Dun-Wei; Tzeng, Yuan-Sheng] Triserv Gen Hosp, Div Plast & Reconstruct Surg, Dept Surg, Natl Def Med Ctr, Taipei, Taiwan.
   [Chen, Chun-Yu] Taoyuan Armed Forces Gen Hosp, Dept Surg, Taoyuan, Taiwan.
   [Chiu, Yu-Lung] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
   [Chiu, Yu-Lung] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical University;
   National Defense Medical University; National Defense Medical University
RP Tzeng, YS (通讯作者)，Triserv Gen Hosp, Div Plast & Reconstruct Surg, Dept Surg, 325,Sec 2,Cheng Gong Rd, Taipei 114, Taiwan.
EM m6246kimo@yahoo.com.tw
RI ; Tzeng, Yuan-sheng/AAD-8843-2020
OI Huang, Dun-Wei/0000-0002-5320-2517; 
FU Ministry of Science and Technology, Taiwan, ROC [MOST
   108-2314-B-016-041]; Tri-Service General Hospital, Taiwan, ROC
   [TSGH-C107-117]
FX This study was supported by a grant, MOST 108-2314-B-016-041, from the
   Ministry of Science and Technology, TSGH-C107-117 from Tri-Service
   General Hospital, Taiwan, ROC.
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NR 14
TC 16
Z9 20
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 30
PY 2020
VL 99
IS 44
AR e23022
DI 10.1097/MD.0000000000023022
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OP6HX
UT WOS:000588186500090
PM 33126386
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rubicondo, C
   Lovece, A
   Pinelli, D
   Indriolo, A
   Lucianetti, A
   Colledan, M
AF Rubicondo, Carolina
   Lovece, Andrea
   Pinelli, Domenico
   Indriolo, Amedeo
   Lucianetti, Alessandro
   Colledan, Michele
TI Endoluminal vacuum-assisted closure (E-Vac) therapy for postoperative
   esophageal fistula: successful case series and literature review
SO WORLD JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Review
DE E-Vac therapy; Oesophageal fistula; Oesophageal leaks; Anastomotic
   leaks; Bronchogenic cyst
ID ANASTOMOTIC LEAKAGE; MANAGEMENT; PERFORATIONS
AB Background Treatment of esophageal perforations and postoperative anastomotic leaks of the upper gastrointestinal tract remains a challenge. Endoluminal vacuum-assisted closure (E-Vac) therapy has positively contributed, in recent years, to the management of upper gastrointestinal tract perforations by using the same principle of vacuum-assisted closure therapy of external wounds. The aim is to provide continuous wound drainage and to promote tissue granulation, decreasing the needed time to heal with a high rate of leakage closure. Cases presentation A series of two different cases with clinical and radiological diagnosis of esophageal fistulas, recorded from 2018 to 2019 period at our institution, is presented. The first one is a case of anastomotic leak after esophagectomy for cancer complicated by pleuro-mediastinal abscess, while the second one is a leak of an esophageal suture, few days after resection of a bronchogenic cyst perforated into the esophageal lumen. Both cases were successfully treated with E-Vac therapy. Conclusion Our experience shows the usefulness of E-Vac therapy in the management of anastomotic and non-anastomotic esophageal fistulas. Further research is needed to better define its indications, to compare it to traditional treatments and to evaluate its long-term efficacy.
C1 [Rubicondo, Carolina; Pinelli, Domenico; Colledan, Michele] ASST Papa Giovanni XXIII, Gen Surg 3, Bergamo, Italy.
   [Lovece, Andrea; Lucianetti, Alessandro] ASST Papa Giovanni XXIII, Gen Surg 1, Piazza OMS 1, I-24127 Bergamo, Italy.
   [Indriolo, Amedeo] ASST Papa Giovanni XXIII, Dept Gastroenterol & Endoscopy, Bergamo, Italy.
C3 ASST Papa Giovanni XXIII; ASST Papa Giovanni XXIII; ASST Papa Giovanni
   XXIII
RP Rubicondo, C (通讯作者)，ASST Papa Giovanni XXIII, Gen Surg 3, Bergamo, Italy.
EM carolinarubicondo1988@gmail.com
RI ; Colledan, Michele/JGM-6908-2023; Pinelli, Domenico/IAS-0685-2023
OI Lovece, Anea/0000-0002-5176-7303; Lucianetti,
   Alessandro/0000-0002-9035-697X
CR Biancari F, 2013, WORLD J SURG, V37, P1051, DOI 10.1007/s00268-013-1951-7
   Blencowe NS, 2012, ANN SURG, V255, P658, DOI 10.1097/SLA.0b013e3182480a6a
   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Bludau M, 2018, SURG ENDOSC, V32, P1906, DOI 10.1007/s00464-017-5883-4
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NR 21
TC 17
Z9 23
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7819
J9 WORLD J SURG ONCOL
JI World J. Surg. Oncol.
PD NOV 14
PY 2020
VL 18
IS 1
AR 301
DI 10.1186/s12957-020-02073-6
PG 7
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA OR0SR
UT WOS:000589188500001
PM 33189152
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kirsner, RS
   Delhougne, G
   Searle, RJ
AF Kirsner, Robert S.
   Delhougne, Gary
   Searle, Richard J.
TI A Cost-Effectiveness Analysis Comparing Single-use and Traditional
   Negative Pressure Wound Therapy to Treat Chronic Venous and Diabetic
   Foot Ulcers
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE cost-effectiveness analysis; negative pressure wound therapy; venous leg
   ulcer; diabetic foot ulcer
ID LEG ULCERS; MINIMIZATION ANALYSIS; CARE; MANAGEMENT; OUTCOMES; BURDEN;
   HEALTH
AB Lower extremity ulcers such as venous leg ulcers (VLUs) and diabetic foot ulcers (DFUs) have a major clinical and economic impact on patients and providers. PURPOSE: The purpose of this economic evaluation was to determine the cost-effectiveness of single-use negative pressure wound therapy (sNPWT) compared with traditional NPWT (tNPWT) for the treatment of VLUs and DFUs in the United States. METHODS: A Markov decision-analytic model was used to compare the incremental cost and ulcer weeks avoided for a time horizon of 12 and 26 weeks using lower extremity ulcer closure rates from a published randomized controlled trial (N = 161) that compared sNPWT with tNPWT. Treatment costs were extracted from a retrospective cost-minimization study of sNPWT and tNPWT from the payer perspective using US national 2016 Medicare claims data inflated to 2018 costs and multiplied by 7 to estimate the weekly costs of treatment for sNPWT and tNPWT. Two (2) arms of the model, tNPWT and sNPWT, were calculated separately for a combination of both VLU and DFU ulcer types. In this model, a hypothetical cohort of patients began in the Open ulcer health state, and at the end of each weekly cycle a proportion of the cohort moved into the Closed ulcer health state according to a constant transition probability. The costs over the defined timescale were summed to give a total cost of treatment for each arm of the model, and then the difference between the arms was calculated. Effectiveness was calculated by noting the incidence of healing at 12 and 26 weeks and the total number of open ulcer weeks; the incremental effectiveness was calculated as sNPWT effectiveness minus tNPWT effectiveness. Data were extracted to Excel spreadsheets and subjected to one-way sensitivity, scenario (where patients with unhealed ulcers were changed to standard care at 4 or 12 weeks), probabilistic, and threshold analyses. RESULTS: sNPWT was found to provide an expected cost saving of $7756 per patient and an expected reduction of 1.67 open ulcer weeks per patient over 12 weeks and a cost reduction of $15 749 and 5.31 open ulcer weeks over 26 weeks. Probabilistic analysis at 26 weeks showed 99.8% of the simulations resulted in sNPWT dominating tNPWT. Scenario analyses showed that sNPWT remained dominant over tNPWT (cost reductions over 26 weeks of $2536 and $7976 per patient, respectively). CONCLUSION: Using sNPWT for VLUs and DFUs is likely to be more cost-effective than tNPWT from the US payer perspective and may provide an opportunity for policymakers to reduce the economic burden of lower extremity ulcers.
C1 [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Univ Miami & Lospital & Clin, Wound Ctr,Dr Phillip Frost Dept Dermatol & Cutane, Miami, FL 33136 USA.
   [Delhougne, Gary] Smith & Nephew Inc, Hlth Econ & Market Access, Ft Worth, TX USA.
   [Searle, Richard J.] Smith & Nephew Med Ltd, HEOR, Kingston Upon Hull, N Humberside, England.
C3 University of Miami; Smith & Nephew; Smith & Nephew
RP Searle, RJ (通讯作者)，Smith & Nephew Med Ltd, 101 Hessle Rd, Kingston Upon Hull, N Humberside, England.
EM richard.searle@smith-nephew.com
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NR 27
TC 12
Z9 12
U1 0
U2 10
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD MAR
PY 2020
VL 66
IS 3
BP 30
EP 38
DI 10.25270/wmp.2020.3.3038
PG 9
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA OR3BW
UT WOS:000589349900002
PM 32294054
DA 2026-07-24
ER
PT J
AU Wright, H
   Kearney, S
   Zhou, K
   Woo, K
AF Wright, Heather
   Kearney, Stephanie
   Zhou, Kevin
   Woo, Kevin
TI Topical Management of Enterocutaneous and Enteroatmospheric Fistulas: A
   Systematic Review
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Review
DE systematic review; enterocutaneous fistula; enteroatmospheric fistula;
   management; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; SMALL-BOWEL FISTULAS;
   ABDOMINAL WOUNDS; OPEN ABDOMEN; EXPERIENCE; RECURRENCE; NUTRITION;
   MORTALITY; REPAIR
AB Enterocutaneous (ECF) and enteroatmospheric (EAF) fistulas are associated with considerable morbidity and patient care challenges, including optimal topical management. PURPOSE: A systematic literature review was conducted to identify topical management interventions used in ECF/EAF care and to explore the role of these interventions in fistula closure and long-term fistula management. METHODS: A search of PubMed, the Cumulative Index of Nursing and Allied Health Literature, and Scopus was conducted to identify English-language articles published from January 2004 to January 2019. The keywords enterocutaneous fistula, enteroatmospheric fistula, negative pressure wound therapy, NPWT, vacuum-assisted closure, VAC, pouch or pouching, troughing, bridging, collection device, dressing, and wound care were used to identify all publications pertaining to the topical management of adult and mixed adult/pediatric patients with an ECF or EAF. Single-person case studies, exclusively pediatric studies, surgical treatment-based, and duplicate publications were excluded. Abstracts were screened for relevance to the research questions, and eligible publications were abstracted and categorized using The Oxford Centre for Evidence-Based Medicine Levels of Evidence. The Joanna Briggs Institute (JBI) critical appraisal checklist for case series was used to assess each article for risk of bias and methodological quality. Outcomes of interest included patient demographics, closure rates, fistula classification (type of fistula, fistula output, fistula origin), type of topical treatment, adverse events (pain, new fistula formation, fistula recurrence, mortality), follow-up, long-term management, perifistula skin protection, effluent management, dressing change frequency, and quality of life. Descriptive statistics were presented; no statistical analysis was performed. RESULTS: Of the 983 articles identified, 57 underwent critical appraisal using the JBI checklist for case series. Forty-two (42) did not meet the inclusion criteria, leaving 15, level IV, case-based publications (N = 410 patients). No randomized controlled trials were found. All studies included some form of negative pressure wound therapy. JBI results found that each study was at high risk of bias in more than 2 domains. Interventions were categorized as intubation, occlusion, or isolation of the fistula. Of the 559 fistulas treated, spontaneous closure was reported in 164 cases, with rates ranging from 0% to 100%. Adverse events to treatment included pain (n = 33 patients), new fistula formation (n = 12), and fistula recurrence (n = 1). Sepsis was the leading cause of mortality (n = 29), with reported rates ranging from 0% to 44%. CONCLUSION: Due to the high risk of study bias and low quality of evidence, the exact contribution of any one intervention could not be established. Results also suggest a high risk of publication bias, and patient-centered outcomes were reported in only 1 study. Although topical management might play a role in fistula closure, it is only as part of a comprehensive plan of care. Future research should focus on developing and using standardized reporting tools, classifications, and outcomes and include patient-centered outcomes such as acceptance, tolerability, pain, and quality of life relating to any one intervention. At this time, the evidence base for management recommendations is limited, suggesting that interventions should mainly be based on practical considerations such as resources and clinician skill.
C1 [Wright, Heather] Keewaytinook Okimakanak First Nat Tribal Council, Wound Ost & Continence Care, Leamington, ON, Canada.
   [Kearney, Stephanie] Queensway Carleton Hosp, Wound Ost & Continence Care, Ottawa, ON, Canada.
   [Zhou, Kevin] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada.
   [Woo, Kevin] Queens Univ, Kingston, ON, Canada.
C3 University of Toronto; Sunnybrook Health Science Center; Sunnybrook
   Research Institute; Queens University - Canada
RP Wright, H (通讯作者)，Keewaytinook Okimakanak Hlth, 69 Alderton St, Leamington, ON, Canada.
EM wright.he@gmail.com
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NR 42
TC 10
Z9 17
U1 0
U2 20
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD APR
PY 2020
VL 66
IS 4
BP 26
EP 37
DI 10.25270/wmp.2020.4.2637
PG 12
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA OR3CX
UT WOS:000589352700002
PM 32294057
DA 2026-07-24
ER
PT J
AU Chandrasekhar, V
   Sureshkumar, S
   Manwar, AS
   Elamurugan, TP
   Nelson, T
   Anandhi, A
   Palanivel, C
AF Chandrasekhar, Vihari
   Sureshkumar, Sathasivam
   Manwar, Ali S.
   Elamurugan, T. P.
   Nelson, Thirugnanasambandam
   Anandhi, Amaranathan
   Palanivel, Chinnakali
TI Negative Pressure Wound Therapy Compared to Petrolatum Gauze and a
   Bogota Bag to Manage Postoperative Midline Abdominal Wound Dehiscence: A
   Pilot, Nonrandomized Controlled Trial
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE clinical trial; surgical wound dehiscence; negative pressure wound
   therapy; granulation tissue; length of stay
ID VACUUM-ASSISTED CLOSURE; FASCIAL CLOSURE; OPEN ABDOMEN; HERNIA RATE
AB Treating postoperative abdominal wound dehiscence following abdominal surgery using negative pressure wound therapy (NPWT) has shown promising results. PURPOSE: A study was conducted to evaluate the efficacy of NPWT for fascial closure/cutaneous cover compared to non-NPWT treatment using petrolatum gauze and a Bogota bag in patients with postoperative laparotomy wound dehiscence. METHODS: A single center, prospective, nonrandomized pilot study was conducted. Using convenience sampling methods, consecutive patients on 6 different surgical units who were at least 18 years of age and who developed postoperative abdominal wound dehiscence following elective and emergency laparotomy from January 2017 to December 2018 were recruited. NPWT dressing with polyvinyl white foam sponge or loosely packed, saline-soaked petrolatum gauze followed by Bogota bag application were used and compared. Baseline patient demographics and history were collected, and patients were followed for an average of 6 months after surgery. Number of days until first signs of granulation tissue appearance, time until complete granulation tissue cover/fascial surgical closure, and hospital discharge were compared. Categorical variables (gender, comorbidities, presence or absence of stoma, exposure to prior radiotherapy) were expressed as proportions and analyzed using chi-squared test or Fischer's exact test. Continuous variables such as age, body mass index, albumin, postoperative hospital stay, and number of days required for decision for fascial closure were expressed as Mean +/- standard deviation and analyzed using an independent t test or Mann Whitney U test based on whether the data followed normal distribution. Postoperative day of wound dehiscence, the number of days for the appearance of granulation tissue, and the number of NPWT placements required also were assessed using Mean +/- standard deviation and analyzed using an independent t test. A P value <.05 was considered significant. RESULTS: Sixty (60) patients were included, but 4 in NPWT group and 10 in the non-NPWT group could not complete the study, leaving 26 patients in NPWT group and 20 patients in non-NPWT group. Demographic and surgical variables were not significantly different. Patients in both groups achieved complete wound coverage by surgical closure or healing by secondary intention. Days until first signs of granulation tissue (2.92 vs. 6.65; P <.001), number of days until fascial closure (15.50 vs. 29.50; P <.001), and length of postoperative hospital stay (24.30 vs. 37.90; P <.001) were significantly less in NPWT group. Two (2) patients (7.6%) in the NPWT developed a fistula during the 6-month follow-up period. No fistulas developed in the control group, and no intra-abdominal abscesses, ventral hernias, or wound dehiscence were reported in either group. CONCLUSION: Time until first signs of granulation tissue appearance and complete granulation tissue coverage was significantly shorter in the NPWT group, but time until definitive closure was not evaluated. Randomized, controlled clinical studies to compare definitive time to wound closure and long-term follow up to evaluate long-term complication rates, including the risk of developing fistulas, are warranted.
C1 [Chandrasekhar, Vihari; Sureshkumar, Sathasivam; Manwar, Ali S.; Elamurugan, T. P.; Nelson, Thirugnanasambandam] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Pondicherry, India.
   [Anandhi, Amaranathan] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Gen Surg, Pondicherry, India.
   [Palanivel, Chinnakali] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Prevent & Social Med, Pondicherry, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Sureshkumar, S (通讯作者)，JIPMER, Surg, Pondicherry 605006, India.
EM drsureshkumar08@gmail.com
RI Amaranathan, Anandhi/K-1169-2019; T P, Elamurugan/IUQ-4480-2023;
   Chinnakali, Palanivel/N-8659-2013
OI Chinnakali, Palanivel/0000-0001-8320-1016
CR Amer H, 2017, EGYPT J SURG, V36, P199, DOI 10.4103/1110-1121.211706
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   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
   Misky A, 2016, COLORECTAL DIS, V18, P846, DOI 10.1111/codi.13351
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NR 18
TC 1
Z9 2
U1 0
U2 11
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD MAY
PY 2020
VL 66
IS 5
BP 37
EP 44
DI 10.25270/wmp.2020.5.3845
PG 8
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA OR3DY
UT WOS:000589355400003
PM 32401733
DA 2026-07-24
ER
PT J
AU Franco-Buenaventura, D
   García-Perdomo, HA
AF Franco-Buenaventura, Daniela
   Garcia-Perdomo, Herney Andres
TI Vacuum-assisted closure device in the postoperative wound care for
   Fournier's gangrene: a systematic review
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Review
DE Fournier gangrene; Negative-pressure wound therapy;
   Vacuum-assisted&#160; closure
ID THERAPY; MANAGEMENT
AB Purpose To determine the effectiveness of Vacuum-Assisted Closure Device in the postoperative wound care for Fournier's gangrene Methods We performed a systematic review in the following databases: Medline (Ovid), EMBASE, and The Cochrane Central Register of Controlled Trials (CENTRAL), from inception to nowadays. We included RCTs and analytical observational studies. Meta-analysis was not possible given the clinical and methodological heterogeneity of the studies. Results We included six studies that compared VAC treated patients and a control group. The length of stay of the VAC treated vs. the conventional dressing treated patients was higher for the VAC treated patients in all but one of the included studies. The VAC group had the highest number of surgical debridements requiring anesthesia. The conventionally treated patients had a higher number of daily dressings, and the need for additional dressing changes, without anesthesia. Two studies found significantly higher mean scores for VAS, requiring a higher need for daily analgesics for the control group patients. Conclusions VAC therapy is an effective method, but it is not better than conventional dressing treatment. VAC carries fewer dressing changes, less pain, and less need for analgesics, but it comes with a higher need for surgical interventions requiring anesthesia.
C1 [Franco-Buenaventura, Daniela; Garcia-Perdomo, Herney Andres] Univ Valle, Sch Med, Dept Surg Urol, Cali, Colombia.
   [Franco-Buenaventura, Daniela; Garcia-Perdomo, Herney Andres] Univ Valle, UROGIV Res Grp, Cll 4B,36-00, Cali, Colombia.
C3 Universidad del Valle; Universidad del Valle
RP García-Perdomo, HA (通讯作者)，Univ Valle, Sch Med, Dept Surg Urol, Cali, Colombia.; García-Perdomo, HA (通讯作者)，Univ Valle, UROGIV Res Grp, Cll 4B,36-00, Cali, Colombia.
EM herney.garcia@correounivalle.edu.co
RI Garcia-Perdomo, Herney Andres/G-9701-2013
OI Garcia-Perdomo, Herney Andres/0000-0001-6945-8261
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NR 25
TC 18
Z9 19
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD APR
PY 2021
VL 53
IS 4
BP 641
EP 653
DI 10.1007/s11255-020-02705-6
EA NOV 2020
PG 13
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA RK2TP
UT WOS:000589478200001
PM 33185760
DA 2026-07-24
ER
PT J
AU Tuuli, MG
   Liu, JX
   Tita, ATN
   Longo, S
   Trudell, A
   Carter, EB
   Shanks, A
   Woolfolk, C
   Caughey, AB
   Warren, DK
   Odibo, AO
   Colditz, G
   Macones, GA
   Harper, L
AF Tuuli, Methodius G.
   Liu, Jingxia
   Tita, Alan T. N.
   Longo, Sherri
   Trudell, Amanda
   Carter, Ebony B.
   Shanks, Anthony
   Woolfolk, Candice
   Caughey, Aaron B.
   Warren, David K.
   Odibo, Anthony O.
   Colditz, Graham
   Macones, George A.
   Harper, Lorie
TI Effect of Prophylactic Negative Pressure Wound Therapy vs Standard Wound
   Dressing on Surgical-Site Infection in Obese Women After Cesarean
   Delivery: A Randomized Clinical Trial
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID POSTDISCHARGE SURVEILLANCE; MATERNAL OBESITY; RISK; MORBIDITY; SECTION
AB IMPORTANCE: Obesity increases the risk of both cesarean delivery and surgical-site infection. Despite widespread use, it is unclear whether prophylactic negative pressure wound therapy reduces surgical-site infection after cesarean delivery in obese women.
   OBJECTIVE: To evaluate whether prophylactic negative pressure wound therapy, initiated immediately after cesarean delivery, lowers the risk of surgical-site infections compared with standard wound dressing in obese women.
   DESIGN, SETTING, AND PARTICIPANTS: Multicenter randomized trial conducted from February 8, 2017, through November 13, 2019, at 4 academic and 2 community hospitals across the United States. Obese women undergoing planned or unplanned cesarean delivery were eligible. The study was terminated after 1624 of 2850 participants were recruited when a planned interim analysis showed increased adverse events in the negative pressure group and futility for the primary outcome. Final follow-up was December 18, 2019.
   INTERVENTIONS: Participants were randomly assigned to either undergo prophylactic negative pressure wound therapy, with application of the negative pressure device immediately after repair of the surgical incision (n = 816), or receive standard wound dressing (n = 808).
   MAIN OUTCOMES AND MEASURES: The primary outcome was superficial or deep surgical-site infection according to the Centers for Disease Control and Prevention definitions. Secondary outcomes included other wound complications, composite of surgical-site infections and other wound complications, and adverse skin reactions.
   RESULTS: Of the 1624 women randomized (mean age, 30.4 years, mean body mass index, 39.5), 1608 (99%) completed the study: 806 in the negative pressure group (median duration of negative pressure, 4 days) and 802 in the standard dressing group. Superficial or deep surgical-site infection was diagnosed in 29 participants (3.6%) in the negative pressure group and 27 (3.4%) in the standard dressing group (difference, 0.36%; 95% CI, -1.46% to 2.19%, P = .70). Of 30 prespecified secondary end points, 25 showed no significant differences, including other wound complications (2.6% vs 3.1%; difference, -0.53%; 95% CI, -1.93% to 0.88%; P = .46) and composite of surgical-site infections and other wound complications (6.5% vs 6.7%; difference, -0.27%; 95% CI, -2.71% to 2.25%; P = .83). Adverse skin reactions were significantly more frequent in the negative pressure group (7.0% vs 0.6%; difference, 6.95%; 95% CI, 1.86% to 12.03%; P < .001).
   CONCLUSIONS and relevance: Among obese women undergoing cesarean delivery, prophylactic negative pressure wound therapy, compared with standard wound dressing, did not significantly reduce the risk of surgical-site infection. These findings do not support routine use of prophylactic negative pressure wound therapy in obese women after cesarean delivery.
C1 [Tuuli, Methodius G.; Shanks, Anthony] Indiana Univ Sch Med, Dept Obstet & Gynecol, 550 N Univ Blvd,2440, Indianapolis, IN 46202 USA.
   [Liu, Jingxia; Colditz, Graham] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA.
   [Tita, Alan T. N.; Harper, Lorie] Univ Alabama Birmingham, Dept Obstet & Gynecol, Birmingham, AL USA.
   [Tita, Alan T. N.; Harper, Lorie] Univ Alabama Birmingham, Ctr Womens Reprod Hlth, Birmingham, AL USA.
   [Longo, Sherri] Ochsner Hlth, Dept Obstet & Gynecol, New Orleans, LA USA.
   [Trudell, Amanda] BJC Med Grp, Div Maternal Fetal Med, St Louis, MO USA.
   [Carter, Ebony B.; Woolfolk, Candice] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA.
   [Caughey, Aaron B.] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97201 USA.
   [Warren, David K.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
   [Odibo, Anthony O.] Univ S Florida, Dept Obstet & Gynecol, Sch Med, Tampa, FL 33620 USA.
   [Macones, George A.] Univ Texas Austin, Dell Sch Med, Dept Obstet & Gynecol, Austin, TX 78712 USA.
C3 Indiana University System; Indiana University Bloomington; Washington
   University (WUSTL); University of Alabama System; University of Alabama
   Birmingham; University of Alabama System; University of Alabama
   Birmingham; Washington University (WUSTL); Oregon Health & Science
   University; Washington University (WUSTL); State University System of
   Florida; University of South Florida; University of Texas System;
   University of Texas Austin
RP Tuuli, MG (通讯作者)，Indiana Univ Sch Med, Dept Obstet & Gynecol, 550 N Univ Blvd,2440, Indianapolis, IN 46202 USA.
EM methodiustuuli@yahoo.com
RI Longo, Sherri/G-3969-2011; Colditz, Graham/A-3963-2009
OI Colditz, Graham/0000-0002-7307-0291; Liu, Jingxia/0000-0002-9434-7907;
   Shanks, Anthony/0000-0001-5916-1683; Warren, David/0000-0001-8679-8241
FU Eunice Kennedy Shriver NICHD [R01HD086007]
FX The study was funded by grant R01HD086007 from the Eunice Kennedy
   Shriver NICHD (Drs Tuuli and Harper). In addition, Acelity donated
   negative pressure devices and provided supplemental funding.
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NR 37
TC 69
Z9 80
U1 0
U2 14
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD SEP 22
PY 2020
VL 324
IS 12
BP 1180
EP 1189
DI 10.1001/jama.2020.13361
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OS4RZ
UT WOS:000590153400031
PM 32960242
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Tabley, A
   Aludaat, C
   Le Guillou, V
   Gay, A
   Nafeh-Bizet, C
   Scherrer, V
   Bouchart, F
   Doguet, F
AF Tabley, Alfred
   Aludaat, Chadi
   Le Guillou, Vincent
   Gay, Arnaud
   Nafeh-Bizet, Catherine
   Scherrer, Vincent
   Bouchart, Francois
   Doguet, Fabien
TI A Survey of Cardiac Surgery Infections With PICO Negative Pressure
   Therapy in High-Risk Patients
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID WOUND THERAPY; COMPLICATIONS; COST
AB Background. Surgical site complications represent major concerns in many surgical specialties and lead to an increased length of hospital stay and the need for additional treatments and care. This investigation aimed to report survey data from the introduction of the PICO negative pressure wound therapy system (Smith & Nephew, Hull, United Kingdom) in a single hospital in France regarding cardiac surgical procedures through standard median sternotomy.
   Methods. The patients in this study were at high risk of developing surgical site infections. PICO was used immediately postoperatively on the closed incision sites in all patients undergoing cardiac surgical procedures. Data were compared with a retrospective cohort of patients in whom PICO had not been used postoperatively. In total, 233 anonymized patient records were reviewed, 142 of which used the PICO device and 91 of which did not.
   Results. PICO was shown to provide both clinical and economic benefits over standard care across a range of different cardiac surgical patients. The rates of complications, including deep surgical wound infections and mediastinitis, were reduced.
   Conclusions. As noted, PICO had advantages over standard care in these patients, and complication rates decreased. This study demonstrated cost savings and an increase in available surgical and hospital capacity related to PICO use. (C) 2020 by The Society of Thoracic Surgeons
C1 [Tabley, Alfred; Aludaat, Chadi; Le Guillou, Vincent; Gay, Arnaud; Nafeh-Bizet, Catherine; Bouchart, Francois; Doguet, Fabien] Rouen Univ Hosp, Dept Cardiovasc & Thorac Surg, 1 Rue Germount, F-76000 Rouen, France.
   [Scherrer, Vincent] Rouen Univ Hosp, Dept Anesthesia & Crit Care, Rouen, France.
   [Doguet, Fabien] Univ Rouen, Normandy Univ, Natl Inst Med Res Unit 1096, Rouen, France.
C3 Centre Hospitalier du Rouvray; Universite de Rouen Normandie; CHU de
   Rouen; Centre Hospitalier du Rouvray; Universite de Rouen Normandie; CHU
   de Rouen; Universite de Rouen Normandie
RP Tabley, A (通讯作者)，Rouen Univ Hosp, Dept Cardiovasc & Thorac Surg, 1 Rue Germount, F-76000 Rouen, France.
EM atabley@gmail.com
RI /ABI-4799-2020
OI aludaat, chadi/0000-0002-9825-3852
CR Berg TC, 2011, EUR J CARDIO-THORAC, V40, P1291, DOI 10.1016/j.ejcts.2011.02.038
   Cotogni Paolo, 2015, World J Crit Care Med, V4, P265, DOI [10.5492/wjccm.v4.i4.265, 10.5492/wjccm.v4.i4.265]
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   Karlakki S, 2013, BONE JOINT RES, V2, P276, DOI 10.1302/2046-3758.212.2000190
   Korol E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083743
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   Mokhtari A, 2008, SCAND CARDIOVASC J, V42, P85, DOI 10.1080/14017430701744469
   Ridderstolpe L, 2001, EUR J CARDIO-THORAC, V20, P1168, DOI 10.1016/S1010-7940(01)00991-5
   Shi YD, 2014, ASIAN J SURG, V37, P24, DOI 10.1016/j.asjsur.2013.07.006
   Siqueira MBP, 2016, WORLD J ORTHOP, V7, P30, DOI 10.5312/wjo.v7.i1.30
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   Wounds International, 2016, CLOS SURG INC MAN UN
NR 17
TC 18
Z9 21
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD DEC
PY 2020
VL 110
IS 6
BP 2034
EP 2040
DI 10.1016/j.athoracsur.2020.03.087
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA OT4YH
UT WOS:000590853100066
PM 32371085
OA Bronze
DA 2026-07-24
ER
PT J
AU Willms, AG
   Schwab, R
   von Websky, MW
   Berrevoet, F
   Tartaglia, D
   Sörelius, K
   Fortelny, RH
   Björck, M
   Monchal, T
   Brennfleck, F
   Bulian, D
   Beltzer, C
   Germer, CT
   Lock, JF
AF Willms, A. G.
   Schwab, R.
   von Websky, M. W.
   Berrevoet, F.
   Tartaglia, D.
   Sorelius, K.
   Fortelny, R. H.
   Bjorck, M.
   Monchal, T.
   Brennfleck, F.
   Bulian, D.
   Beltzer, C.
   Germer, C. T.
   Lock, J. F.
CA Eurahs Open Abdomen Grp
TI Factors influencing the fascial closure rate after open abdomen
   treatment: Results from the European Hernia Society (EuraHS) Registry
   Surgical technique matters
SO HERNIA
LA English
DT Article
DE Open abdomen; Peritonitis; Fascial closure; Hernia; Abdominal
   compartment syndrome; Abdominal trauma; Burst abdomen; NPWT; VAC
ID ASSISTED WOUND CLOSURE; TEMPORARY ABDOMINAL CLOSURE; SEPTIC PATIENTS;
   CONSENSUS DEFINITIONS; DELAYED CLOSURE; DAMAGE CONTROL; VACUUM; MESH;
   THERAPY; TRACTION
AB Purpose Definitive fascial closure is an essential treatment objective after open abdomen treatment and mitigates morbidity and mortality. There is a paucity of evidence on factors that promote or prevent definitive fascial closure. Methods A multi-center multivariable analysis of data from the Open Abdomen Route of the European Hernia Society included all cases between 1 May 2015 and 31 December 2019. Different treatment elements, i.e. the use of a visceral protective layer, negative-pressure wound therapy and dynamic closure techniques, as well as patient characteristics were included in the multivariable analysis. The study was registered in the International Clinical Trials Registry Platform via the German Registry for Clinical Trials (DRK00021719). Results Data were included from 630 patients from eleven surgical departments in six European countries. Indications for OAT were peritonitis (46%), abdominal compartment syndrome (20.5%), burst abdomen (11.3%), abdominal trauma (9%), and other conditions (13.2%). The overall definitive fascial closure rate was 57.5% in the intention-to-treat analysis and 71% in the per-protocol analysis. The multivariable analysis showed a positive correlation of negative-pressure wound therapy (odds ratio: 2.496, p < 0.001) and dynamic closure techniques (odds ratio: 2.687, p < 0.001) with fascial closure and a negative correlation of intra-abdominal contamination (odds ratio: 0.630, p = 0.029) and the number of surgical procedures before OAT (odds ratio: 0.740, p = 0.005) with DFC. Conclusion The clinical course and prognosis of open abdomen treatment can significantly be improved by the use of treatment elements such as negative-pressure wound therapy and dynamic closure techniques, which are associated with definitive fascial closure.
C1 [Willms, A. G.; Schwab, R.] German Armed Forces Cent Hosp Koblenz, Dept Gen Visceral & Thorac Surg, Rubenacher Str 170, D-56072 Koblenz, Germany.
   [von Websky, M. W.] Univ Hosp Bonn, Dept Gen Visceral Thorac & Vasc Surg, Sigmund Freud Str 25, D-53127 Bonn, Germany.
   [Berrevoet, F.] Ghent Univ Hosp, Dept Gen & HPB Surg & Liver Transplantat, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
   [Tartaglia, D.] Cisanello Univ Hosp, Emergency Surg Unit, Via Paradisa 1, I-56124 Pisa, Italy.
   [Bjorck, M.] Uppsala Univ, Dept Surg Sci, Sect Vasc Surg, SE-75185 Uppsala, Sweden.
   [Sorelius, K.] Univ Copenhagen, Rigshosp, Dept Vasc Surg, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
   [Sorelius, K.] Univ Copenhagen, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
   [Fortelny, R. H.] Wilhelminenspital Stadt Wien, Dept Gen Visceral & Oncol Surg, A-1160 Vienna, Austria.
   [Fortelny, R. H.] Sigmund Freud Univ Vienna, Med Fac, A-1020 Vienna, Austria.
   [Monchal, T.] St Anne Mil Hosp, Dept Gen Surg, 2 Blvd St Anne, F-83000 Toulon, France.
   [Brennfleck, F.] Regensburg Univ Hosp, Dept Surg, Franz Josef Str Allee 11, D-93053 Regensburg, Germany.
   [Bulian, D.] Witten Herdecke Univ, Cologne Merheim Med Ctr, Dept Abdominal Tumor Transplant & Vasc Surg, Ostmerheimer Str 200, D-51109 Cologne, Germany.
   [Beltzer, C.] German Armed Forces Hosp Ulm, Dept Gen Visceral & Thorac Surg, Ulm, Germany.
   [Germer, C. T.; Lock, J. F.] Univ Hosp Wurzburg, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany.
C3 University of Bonn; Ghent University; Ghent University Hospital; Uppsala
   University; University of Copenhagen; Rigshospitalet; University of
   Copenhagen; Wilhelminenspital; University of Regensburg; Ulm University;
   Military Hospital Ulm; University of Wurzburg
RP Lock, JF (通讯作者)，Univ Hosp Wurzburg, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany.
EM Lock_J@ukw.de
RI Brennfleck, Frank/GOV-6490-2022; Bulian, Dirk Rolf/GQY-7923-2022; Lock,
   Johan/AAA-8114-2020; Tartaglia, Dario/AAJ-1735-2020; von Websky,
   Martin/AFC-6767-2022; /AFN-0812-2022; Fortelny, René/AAD-5922-2021;
   Berrevoet, Frederik/A-6117-2008
OI Brennfleck, Frank/0000-0001-8055-9282; Bulian, Dirk
   Rolf/0000-0002-1311-7326; Lock, Johan/0000-0002-9007-3937; Beltzer,
   Christian/0000-0002-1163-6982
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL. No funding
   was received for this work.
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NR 50
TC 17
Z9 23
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD FEB
PY 2022
VL 26
IS 1
BP 61
EP 73
DI 10.1007/s10029-020-02336-x
EA NOV 2020
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ZH9CJ
UT WOS:000591096300001
PM 33219419
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Weréen, A
   Dahlberg, M
   Heinius, G
   Pieniowski, E
   Saraste, D
   Eklöv, K
   Nygren, J
   Pekkari, K
   Everhov, ÅH
AF Wereen, Alice
   Dahlberg, Martin
   Heinius, Goeran
   Pieniowski, Emil
   Saraste, Deborah
   Eklov, Karolina
   Nygren, Jonas
   Pekkari, Klas
   Everhov, Asa H.
TI Long-Term Results after Anastomotic Leakage following Rectal Cancer
   Surgery: A Comparison of Treatment with Endo-Sponge and Transanal
   Irrigation
SO DIGESTIVE SURGERY
LA English
DT Article
DE Rectal neoplasm; Anastomotic leak; Surgical sponge; Endo-SPONGE;
   Endoscopic vacuum-assisted closure; TME
ID LOW ANTERIOR RESECTION; ENDOSCOPIC VACUUM THERAPY; ASSISTED CLOSURE;
   DRAINAGE; MANAGEMENT; EXPERIENCE; EFFICACY; ETVARD; STOMA; RISK
AB Objective: We aimed to evaluate long-term results in patients from regular health care treated with endoscopic transanal closure system, that is, endoscopic vacuum-assisted closure system (EVAC) compared to transanal irrigation. Methods: In this retrospective, medical chart-based, observational study, we included patients with anastomotic leakage after low anterior resection for rectal cancer from 3 Stockholm hospitals 2006-2016 and compared time to first stoma closure in a Kaplan-Meier model and the proportion of patients who were stoma-free at end of follow-up. Results: Anastomotic leakage was found in 81 patients who were followed up in median 5.9 years (min-max: 0.53-13). EVAC was used on 14 (17%) patients and transanal irrigation on 34 (42%) patients. The remaining 33 (41%) patients either got a permanent colostomy or were treated only with antibiotics and percutaneous drainage. Treatment with EVAC or transanal irrigation led to similar rates of stoma closure, both when comparing all patients, and when comparing patients with similar defects. At the end of follow-up, 43% of patients treated with EVAC and 50% of patients treated with repeated irrigation were stoma-free (p = 0.75). Conclusions: We found no evidence of better outcomes in patients treated with EVAC. The study was, however, limited by small sample size.
C1 [Wereen, Alice; Dahlberg, Martin; Heinius, Goeran; Eklov, Karolina; Everhov, Asa H.] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.
   [Pieniowski, Emil; Saraste, Deborah] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Nygren, Jonas; Pekkari, Klas] Karolinska Inst, Ersta Hosp, Dept Surg, Stockholm, Sweden.
   [Nygren, Jonas; Pekkari, Klas] Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
   [Everhov, Asa H.] Karolinska Inst, Clin Epidemiol Div, Dept Med Solna, Stockholm, Sweden.
C3 Karolinska Institutet; Sodersjukhuset Hospital; Karolinska Institutet;
   Karolinska Institutet; Ersta Sjukhus; Karolinska Institutet; Danderyds
   Hospital; Karolinska Institutet
RP Everhov, ÅH (通讯作者)，Stockholm South Gen Hosp, Dept Surg, SE-11861 Stockholm, Sweden.
EM asa.hallqvist-everhov@ki.se
RI Everhov, Åsa H/E-4399-2018; Pekkari, Klas/AAA-5124-2022; Nygren,
   Jonas/AAQ-2775-2021; Saraste, Deborah/ACE-2715-2022
OI Everhov, Åsa H/0000-0002-0311-8894; Saraste,
   Deborah/0000-0002-2931-2652; 
FU Karolinska Institutet, Bengt Ihre Foundation; Bengt Ihre Research
   Fellowship
FX This project was funded by Karolinska Institutet, Bengt Ihre Foundation,
   and the Bengt Ihre Research Fellowship.
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NR 24
TC 12
Z9 12
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0253-4886
EI 1421-9883
J9 DIGEST SURG
JI Dig. Surg.
PD NOV
PY 2020
VL 37
IS 6
BP 456
EP 462
DI 10.1159/000508935
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA OT9RD
UT WOS:000591173500003
PM 32829324
DA 2026-07-24
ER
PT J
AU Nuhi, A
AF Nuhi, Arslani
TI Case Study: Infected Disrupted Perineal Wound Treatment with Negative
   Pressure Wound Therapy (NPWT) and Wound Reconstruction Using Gracilis
   Muscle Flap Following the Abdominoperineal Excision (APE) in Patient
   with Rectum Injury Due to Motorcycle Accident
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Rectum injury; APE; NPWT; Gracilis muscle flap; Interdisciplinary
   approach
ID MANAGEMENT
AB Blunt trauma sustained in traffic accidents can cause significant rectum injury, either intra or extraperitoneal. Severe injuries have high mortality rates and many complications, including pelvic absesses, sepsis, rectal fistulas, stenosis, and rectal incontinence. Following the initial surgical procedure, many reconstructive methods can be used to treat perineal wounds, including gracilis myocutaneus flap, rectus abdominis flap, gluteal flap, perforator flap, posterior thigh flap, groin flap, and pudendal fasciocutaneous flap. NPWT is used to promote formation of granulation tissue, reduce and prepare tissue gap to be covered, improve perfusion through removal of excessive fluid, and reduce bacterial wound colonization. Some of the complications of this method are pain, skin irritation and maceration, tissue necrosis, bleeding, and infection. The success rate of NPWT depends on multiple factors, including patient characteristics, effectiveness of primary surgical procedure and need for further surgical interventions, size and depth of the wound, and proper NPWT application technique. NPWT has shown to reduce total treatment cost due to shorter patient hospital stay, reduction of complication rates, reduction of further surgical interventions, and lower frequency of dressing change compared with standard dressings. In this case study, I present a 53-year-old motorcyclist who was injured in a traffic accident and sustained fracture of the sacrum, rupture of the pubic symphysis, fracture of L5 vertebrae, and penetrant injury to the rectum. Multiple explorative laparotomies, colostomy, and supportive and drug treatment methods were carried out to obtain a successful outcome.
C1 [Nuhi, Arslani] Univ Med Ctr Maribor, Dept Abdominal & Gen Surg, Maribor, Slovenia.
C3 University of Maribor
RP Nuhi, A (通讯作者)，Univ Med Ctr Maribor, Dept Abdominal & Gen Surg, Maribor, Slovenia.
EM nuhi.arslani@gmail.com
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NR 8
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD APR
PY 2021
VL 83
IS SUPPL 1
SU 1
SI SI
BP S222
EP S224
DI 10.1007/s12262-020-02099-w
EA NOV 2020
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB9DV
UT WOS:000591229400002
DA 2026-07-24
ER
PT J
AU Petersson, P
   Petersson, U
AF Petersson, Patrik
   Petersson, Ulf
TI Dynamic Fascial Closure With Vacuum-Assisted Wound Closure and
   Mesh-Mediated Fascial Traction (VAWCM) Treatment of the Open Abdomen-An
   Updated Systematic Review
SO FRONTIERS IN SURGERY
LA English
DT Review
DE open abdomen; negative pressure wound therapy (NPWT); vacuum assisted
   wound closure and mesh-mediated fascial traction; VAWCM; dynamic closure
   technique; temporary abdominal closure (TAC)
ID NEGATIVE-PRESSURE; THERAPY; MANAGEMENT; OUTCOMES
AB Introduction: Several different temporary abdominal closure techniques are described in the context of open abdomen treatment. Techniques based on dynamic fascial closure combined with negative pressure therapy have gained popularity and seem to result in the highest fascial closure rates without increased complications and are highlighted in recent guidelines and recommendations. One dynamic closure technique is the vacuum-assisted wound closure and mesh-mediated fascial traction (VAWCM) technique, first described in 2007. The aim of this systematic review was to evaluate the VAWCM technique regarding a number of short- and long-term results.
   Materials and Methods: A systematic literature search was performed in PubMed, EMBASE, and Cochrane Library databases for articles published between January 1, 2006 and May 8, 2020. The review was independently performed by the two authors according to the PRISMA statements for reporting systematic reviews and meta-analyses. Results were pooled for presentation of weighted means when applicable.
   Results: A total of 220 articles were screened by title and abstract. Thirty-two articles were assessed for eligibility by full-text review and 15 articles finally remained for review. A total of 600 patients treated with VAWCM were included. The pooled weighted means were as follows: fascial closure, 83.5%; enteroatmospheric fistula, 5.6%; planned ventral hernia, 6.2%; in-hospital survival, 72%; and incisional hernia incidence, 40.5%. Long-term survival ranged between 22 and 72%. Quality of life (SF-36) was reported in two studies showing lower scores than the population mean especially in physical domains. Incisional hernia resulted in lower scores in one but not in the other study.
   Discussion: The results of 600 VAWCM-treated patients from 15 studies were evaluated in this systematic review. Earlier findings with high fascial closure rates, low enteroatmospheric fistula, and planned ventral hernia rates as well as high incisional hernia incidences were underlined. Permanent mesh for efficient fascial traction and reinforcement at fascial closure seem to be the next step in evolving an optimal temporary closure technique in open abdomen treatment.
C1 [Petersson, Patrik; Petersson, Ulf] Lund Univ, Fac Med, Dept Clin Sci, Lund, Sweden.
   [Petersson, Patrik; Petersson, Ulf] Skane Univ Hosp, Dept Surg, Malmo, Sweden.
C3 Lund University; Lund University; Skane University Hospital
RP Petersson, P (通讯作者)，Lund Univ, Fac Med, Dept Clin Sci, Lund, Sweden.; Petersson, P (通讯作者)，Skane Univ Hosp, Dept Surg, Malmo, Sweden.
EM patrik.a.petersson@telia.com
OI Kjärsgård Pettersson, Patrik/0000-0003-0250-1004
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Acosta S, 2017, EUR J VASC ENDOVASC, V54, P697, DOI 10.1016/j.ejvs.2017.09.002
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   Willms A, 2016, HERNIA, V20, P849, DOI 10.1007/s10029-016-1534-2
   Willms A, 2015, LANGENBECK ARCH SURG, V400, P91, DOI 10.1007/s00423-014-1240-4
NR 32
TC 25
Z9 29
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD NOV 5
PY 2020
VL 7
AR 577104
DI 10.3389/fsurg.2020.577104
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OU5VV
UT WOS:000591597300001
PM 33251242
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Choi, SI
   Park, JC
   Jung, DH
   Shin, SK
   Lee, SK
   Lee, YC
AF Choi, Soo In
   Park, Jun Chul
   Jung, Da Hyun
   Shin, Sung Kwan
   Lee, Sang Kil
   Lee, Yong Chan
TI Efficacy of Endoscopic Vacuum-Assisted Closure Treatment for
   Postoperative Anastomotic Leak in Gastric Cancer
SO GUT AND LIVER
LA English
DT Article
DE Vacuum assisted closure; Anastomotic leak; Gastrectomy; Self-expandable
   metallic stents; Stomach neoplasms
ID ESOPHAGEAL STENT; MANAGEMENT; THERAPY; COMPLICATIONS; GASTRECTOMY;
   SURGERY; FISTULAS
AB Background/Alms: Endoscopic vacuum-assisted closure (EVAC) has been attempted as new nonsurgical treatment for anastomotic leakage. We aimed to evaluate the clinical outcomes of EVAC and compare its efficacy with the self-expandable metallic stent (SEMS) for postgastrectomy leakage. Methods: Between January 2007 and February 2018, 39 patients underwent endoscopic treatment for anastomotic leakage after gastric cancer surgery. Of them, 28 patients were treated with SEMS, seven with EVAC after SEMS failure, and four with EVAC. We retrospectively compared the clinical characteristics and therapeutic outcomes between EVAC (n=11) and SEMS (n=28). Results: The median follow-up duration was 17 months (interquartile range, 9 to 26 months) in both groups. In comparison of clinical characteristics between two groups, only the median size of the leak was larger in the EVAC group than in the SEMS group (2.1 cm vs 1.0 cm; p<0.001). All EVAC cases healed successfully, however, two cases (7.1%) failed to heal in the SEMS group. Anastomotic stricture occurred one case (9.1%) in EVAC and four cases (14.3%) in SEMS within 1 year after endoscopic treatment. The median treatment duration of EVAC was shorter than that of SEMS (15 days vs 36 days; p<0.001). Median weight loss after therapy was similar in both groups (8.0 kg in EVAC vs 9.0 kg in SEMS; p=0.356). Conclusions: EVAC can be effective endoscopic treatment for postgastrectomy anastomotic leakage. Substantial leakage could be an important clinical factor for considering EVAC as a treatment option. Large randomized controlled trials are needed to confirm the efficacy of EVAC.
C1 [Choi, Soo In] Inje Univ, Div Gastroenterol, Dept Internal Med, Sanggye Paik Hosp,Coll Med, Seoul, South Korea.
   [Park, Jun Chul; Jung, Da Hyun; Shin, Sung Kwan; Lee, Sang Kil; Lee, Yong Chan] Yonsei Univ, Div Gastroenterol, Dept Internal Med, Severance Hosp,Inst Gastroenterol,Coll Med, Seoul, South Korea.
C3 Inje University; Yonsei University; Yonsei University Health System;
   Severance Hospital
RP Park, JC (通讯作者)，Yonsei Univ, Div Gastroenterol, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03727, South Korea.
EM JUNCHUL75@yuhs.ac
RI ; Park, Jun Chul/H-7218-2019
OI Lee, Yong Chan/0000-0001-8800-6906; Shin, Sung Kwan/0000-0001-5466-1400;
   Park, Jun Chul/0000-0001-8018-0010; Jung, Da Hyun/0000-0001-6668-3113;
   Lee, Sang Kil/0000-0002-0721-0364; Choi, Soo In/0000-0001-6156-5898
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NR 35
TC 11
Z9 16
U1 0
U2 1
PU EDITORIAL OFFICE GUT & LIVER
PI SEOUL
PA 305 LOTTE GOLD ROSE II, 890-59, DAECHI 4-DONG, GANGNAM-GU, SEOUL,
   135-839, SOUTH KOREA
SN 1976-2283
EI 2005-1212
J9 GUT LIVER
JI Gut Liver
PD NOV
PY 2020
VL 14
IS 6
BP 746
EP 754
DI 10.5009/gnl20114
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA OU6TT
UT WOS:000591659600008
PM 33024061
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Brennfleck, FW
   Linsenmeier, L
   Junger, HHG
   Schmidt, KM
   Werner, JM
   Woehl, D
   Zeman, F
   Mutzbauer, I
   Hutchinson, JA
   Geissler, EK
   Schlitt, HJ
   Brunner, SM
AF Brennfleck, Frank W.
   Linsenmeier, Lena
   Junger, Henrik H. G.
   Schmidt, Katharina M.
   Werner, Jens M.
   Woehl, Daniel
   Zeman, Florian
   Mutzbauer, Ingrid
   Hutchinson, James A.
   Geissler, Edward K.
   Schlitt, Hans J.
   Brunner, Stefan M.
TI Negative pressure wound therapy (NPWT) on closed incisions to prevent
   surgical site infection in high-risk patients in hepatopancreatobiliary
   surgery: study protocol for a randomized controlled trial-the NP-SSI
   trial
SO TRIALS
LA English
DT Article
DE NP-SSI; SSI; NPWT; ciNPWT; Incision management; Prevena; Wound
   infection; HPB surgery; Randomized controlled trial
ID COMPLICATIONS; RESECTION; PREVALENCE; RECURRENCE; LAPAROTOMY;
   MANAGEMENT; DRESSINGS; OUTCOMES; IMPACT
AB BackgroundIncisional surgical site infections (iSSI) in hepatopancreatobiliary (HPB) surgery usually lead to prolonged hospital stays, consume valuable resources, and impact on patients' outcome. Prophylactic closed incision negative pressure wound therapy (ciNPWT) to decrease wound complications has become available. Owing to an increasing number of studies, evidence for superiority in many indication areas has accumulated; however, in general surgery, there are a few data and those have shown contradictory results.MethodsIn this monocentric, prospective, randomized, controlled, two-armed study, the influence of ciNPWT on incisional surgical site infection rates after HPB operations will be investigated. A total of 222 patients will be randomized 1:1 to an interventional group (7-day treatment with ciNPWT) or a control group (treated with gauze dressing). The primary parameter to evaluate efficacy is the rate of incisional SSIs within 30days after surgery. Additionally, several clinically relevant secondary outcomes will be assessed.DiscussionA reduction in the rate of incisional SSIs would not only lead to a significant cost reduction and shorter postoperative length of stay, but may also improve postoperative quality of life for patients. While earlier publications have shown advantages for ciNPWT, recent studies did not confirm a positive effect regarding iSSI rate. Even if iSSI rate is not reduced, findings obtained from the secondary endpoints may be of clinical relevance, such as reduction of wound complication rates.Trial registrationThis trial has been registered in the German Clinical Trials Register, DRKS 00015136. Registered on 19 February 2019 and has been approved by the local ethics committee of the University of Regensburg: 18-1225-101.
C1 [Brennfleck, Frank W.; Linsenmeier, Lena; Junger, Henrik H. G.; Schmidt, Katharina M.; Werner, Jens M.; Woehl, Daniel; Mutzbauer, Ingrid; Hutchinson, James A.; Geissler, Edward K.; Schlitt, Hans J.; Brunner, Stefan M.] Univ Hosp Regensburg, Dept Surg, Franz Josef Str Allee 11, D-93053 Regensburg, Germany.
   [Zeman, Florian] Univ Hosp Regensburg, Ctr Clin Trials, Franz Josef Str Allee 11, D-93053 Regensburg, Germany.
C3 University of Regensburg; University of Regensburg
RP Brennfleck, FW (通讯作者)，Univ Hosp Regensburg, Dept Surg, Franz Josef Str Allee 11, D-93053 Regensburg, Germany.
EM frank.brennfleck@klinik.uni-regensburg.de
RI Schlitt, Hans/ABG-4368-2020; Geissler, Edward/R-4131-2016; Hutchinson,
   James/H-3401-2019; Brunner, Stefan/PGF-2582-2026; Brennfleck,
   Frank/GOV-6490-2022; Zeman, Florian/GNH-3239-2022
OI Brennfleck, Frank/0000-0001-8055-9282; Zeman,
   Florian/0000-0002-8425-984X; Werner, Jens/0000-0001-7156-4370
FU KCI Europe Holding B. V (Utrecht, NL)
FX The costs incurred for data management, statistics, monitoring, and the
   administration of the study are partly financed by KCI Europe Holding B.
   V (Utrecht, NL). The company is not involved in these processes and has
   no access to the data. The Prevena dressings and devices are provided
   free of charge by KCI Europe Holding B. V (Utrecht, NL). There is no
   influence or restriction on publications. The study has been initiated,
   planned, and will be managed by the independent authors without conflict
   of interest. The funding company has not been participating in design of
   the study, data collection, interpretation of data, or writing the final
   manuscript. Open Access funding enabled and organized by Projekt DEAL.
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NR 49
TC 5
Z9 6
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD NOV 9
PY 2020
VL 21
IS 1
AR 918
DI 10.1186/s13063-020-04831-z
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA OU9EZ
UT WOS:000591827600003
PM 33168081
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rashed, A
   Csiszar, M
   Beledi, A
   Gombocz, K
AF Rashed, Aref
   Csiszar, Marton
   Beledi, Agnes
   Gombocz, Karoly
TI The impact of incisional negative pressure wound therapy on the wound
   healing process after midline sternotomy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE deep sternal wound infections; incisional negative pressure wound
   therapy; inflammatory biomarkers; proliferation phase; wound healing
   process
ID INFECTIONS; PREVENTION; RISK; MEDIASTINITIS; SURGERY
AB Previous studies have reported that the use of incisional negative pressure wound therapy (INPWT) might reduce the incidence of wound infections, although its mechanism remains unknown. We designed a prospective study to explore the effects of INPWT on different stages of the wound healing process. After meeting the inclusion criteria, 108 patients were enrolled. Based on exclusion criteria four patients were excluded and 104 patients were randomised into two groups. INPWT was applied after primary closure of the midline sternotomy in the study group (n = 52), while conventional wound dressing was applied in the control group (n = 52). We documented the incidence of deep sternal wound infections and analysed the pre- and postoperative inflammatory biomarkers and scar size in both groups. No wound infections were observed in the study group compared with six cases (11.1%) in the control group, (P = .026). No significant differences were observed in the inflammatory biomarkers between the groups. Scar size was significantly smaller in the study group. We concluded that INPWT has less effect on the inflammatory phase and appears to have more effect on the proliferation phase through pronounced scar formation.
C1 [Rashed, Aref; Beledi, Agnes; Gombocz, Karoly] Zala Cty St Raphael Hosp, Dept Cardiac Surg, Zrinyi M Str 1, H-8900 Zalaegerszeg, Hungary.
   [Csiszar, Marton] Zala Cty St Raphael Hosp, Dept Radiol, Zalaegerszeg, Hungary.
RP Rashed, A (通讯作者)，Zala Cty St Raphael Hosp, Dept Cardiac Surg, Zrinyi M Str 1, H-8900 Zalaegerszeg, Hungary.
EM aref.rashed.szv@zmkorhaz.hu
RI /AAO-3555-2020
CR Abboud CS, 2004, ANN THORAC SURG, V77, P676, DOI 10.1016/S0003-4975(03)01523-6
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NR 20
TC 18
Z9 24
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2021
VL 18
IS 1
BP 95
EP 102
DI 10.1111/iwj.13497
EA NOV 2020
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QE1EZ
UT WOS:000591996600001
PM 33236860
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Kaneko, T
   Funahashi, K
   Ushigome, M
   Kagami, S
   Goto, M
   Koda, T
   Kurihara, A
AF Kaneko, Tomoaki
   Funahashi, Kimihiko
   Ushigome, Mitstunori
   Kagami, Satoru
   Goto, Mayu
   Koda, Takamaru
   Kurihara, Akiharu
TI Incisional negative pressure wound therapy to reduce perineal wound
   infection after abdominoperineal resection
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
ID SURGICAL SITE INFECTIONS; VACUUM-ASSISTED CLOSURE; EXCISION ELAPE;
   RECTAL-CANCER; HIGH-RISK; RECONSTRUCTION; MANAGEMENT; COMPLICATIONS;
   DECREASES
AB We explored the effects of incisional negative pressure wound therapy in perineal wound infections after abdominoperineal resection. We retrospectively evaluated 146 patients who underwent abdominal perineal resection from December 2004 to December 2019 and compared conventional gauze dressing (controls) with incisional negative pressure wound therapy. We compared patients' characteristics, surgical factors, and perineal infection rates between groups, and patients' characteristics, surgical factors, and negative pressure therapy use between perineal infection vs non-infection groups, as well as the risk factors for perineal infections. In the negative pressure therapy group, compared with controls, the number of men, smoking prevalence, blood transfusion, drainage via the perineal wound, and intraoperative blood loss were significantly lower (p < 0.05, p < 0.05, p < 0.05, p < 0.001, p < 0.01, respectively), and operation time was significantly longer (p < 0.05). Infections were significantly less common in the negative pressure group (p < 0.05). In the univariate analysis, the infection-positive group had significantly higher laparoscopic surgery (p < 0.01) and negative pressure wound therapy-free rates (p < 0.01), and significantly more intraoperative blood loss (p < 0.05). Multivariate analysis using these three factors and preoperative radiotherapy showed that incisional negative pressure wound therapy-free status was a risk factor for infection. Incisional negative pressure wound therapy was beneficial in managing perineal wound infections after abdominoperineal resection.
C1 [Kaneko, Tomoaki; Funahashi, Kimihiko; Ushigome, Mitstunori; Kagami, Satoru; Goto, Mayu; Koda, Takamaru; Kurihara, Akiharu] Toho Univ, Omori Med Ctr, Dept Gastroenterol Surg, Tokyo, Japan.
C3 Toho University
RP Kaneko, T (通讯作者)，Toho Univ, Omori Med Ctr, Dept Gastroenterol Surg, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438541, Japan.
EM tomoaki.kaneko@med.toho-u.ac.jp
OI Funahashi, Kimihiko/0000-0001-5158-9378
CR Althumairi AA, 2016, WORLD J SURG, V40, P1755, DOI 10.1007/s00268-016-3450-0
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NR 29
TC 8
Z9 11
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2021
VL 18
IS 1
BP 103
EP 111
DI 10.1111/iwj.13499
EA NOV 2020
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QE1EZ
UT WOS:000592001100001
PM 33236842
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Akhter, AS
   McGahan, BG
   Close, L
   Dornbos, D 
   Toop, N
   Thomas, NR
   Christ, E
   Dahdaleh, NS
   Grossbach, AJ
AF Akhter, Asad S.
   McGahan, Benjamin G.
   Close, Liesl
   Dornbos, David, III
   Toop, Nathaniel
   Thomas, Nicholas R.
   Christ, Elizabeth
   Dahdaleh, Nader S.
   Grossbach, Andrew J.
TI Negative pressure wound therapy in spinal fusion patients
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE fusion; negative pressure wound therapy; outcomes; spine; surgical site
   infection
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTION; RISK-FACTORS; SURGERY;
   NPWT
AB Post-operative wound complications are some of the most common acute complications following spine surgery. These surgical site infections (SSI) contribute to increased healthcare related costs. Negative pressure wound therapy (NPWT) has long been used for treatment of soft tissue injury or defects. NPWT may reduce the incident of SSI following spinal fusion procedures; however, its potential applications need further clarification. Thus, we conducted a retrospective analysis of two cohorts to compare NPWT to traditional sterile dressings following spinal fusions in regards to post-operative outcomes. Following institutional review board approval, 42 patients who had a NPWT were matched by type of surgery to 42 patients who had traditional dressings. A retrospective chart-review was completed. Outcome measures, particularly SSI and need for reoperation, were analyzed using one-way ANOVA for both univariate and multivariate analysis. When controlled for sex and body-mass index, the use of a NPWT was independently correlated with decreased SSI (P = .035). Superficial dehiscence, seroma, need for additional outpatient care, and need for operative revision were all found to occur at higher rates in the traditional dressing cohort. Closed incisional negative pressure wound therapy provides a cost-effective method of decreasing surgical site infection for posterior elective spine surgeries.
C1 [Akhter, Asad S.; McGahan, Benjamin G.; Dornbos, David, III; Toop, Nathaniel; Christ, Elizabeth; Grossbach, Andrew J.] Ohio State Univ, Dept Neurosurg, Wexner Med Ctr, Columbus, OH 43210 USA.
   [Close, Liesl] Univ Iowa, Carver Coll Med, Dept Neurosurg, Iowa City, IA USA.
   [Thomas, Nicholas R.] Northeast Ohio Med Univ, Sch Med, Rootstown, OH USA.
   [Dahdaleh, Nader S.] Northwestern Univ, Feinberg Sch Med, Dept Neurosurg, Chicago, IL 60611 USA.
C3 University System of Ohio; Ohio State University; University of Iowa;
   University System of Ohio; Northeast Ohio Medical University (NEOMED);
   Northwestern University; Feinberg School of Medicine
RP Akhter, AS (通讯作者)，Ohio State Univ, Dept Neurosurg, Wexner Med Ctr, Columbus, OH 43210 USA.
EM asad.akhter@osumc.edu
RI ; Dornbos, David/AAF-5091-2019
OI Toop, Nathaniel/0009-0004-6586-1060; 
FU Acelity KCI
FX Acelity KCI
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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NR 33
TC 27
Z9 29
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2021
VL 18
IS 2
BP 158
EP 163
DI 10.1111/iwj.13507
EA NOV 2020
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA RC7KR
UT WOS:000592008600001
PM 33236841
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Lin, DZ
   Kao, YC
   Chen, CH
   Wang, HJ
   Chiu, WK
AF Lin, Dai-Zhu
   Kao, Yu-Chien
   Chen, Chiehfeng
   Wang, Hsian-Jenn
   Chiu, Wen-Kuan
TI Negative pressure wound therapy for burn patients: A meta-analysis and
   systematic review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; DERMAL SUBSTITUTION;
   RECONSTRUCTIVE SURGERY; MANAGEMENT; EFFICACY
AB Negative pressure wound therapy (NPWT), which has been applied in various medical specialties to accelerate wound healing, has been the object of a few investigations. We explored the effectiveness of NPWT and the possibility of its inclusion in burn management guidelines. Randomised controlled trials comparing NPWT with non-NPWT treatments for burn wounds were extracted from PubMed. For the risk of bias analysis, all included studies were evaluated according to the Cochrane risk of bias tool and the approaches outlined in the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) Handbook. Outcomes such as graft take rate in the first week, infection rate, and overall complication rate were analysed. Six studies that included a total of 701 patients met our inclusion criteria. Qualitative analysis revealed that the NPWT group had a significantly better overall graft rate in the first week (P = 0.001) and a significantly lower infection rate (P = 0.04). No significant difference in the overall complication rate was found. Our results indicate that NPWT is a safe method for stimulating healing and lowering the infection rate of burn wounds. NPWT can be part of general burn management, and its incorporation into burn treatment guidelines is recommended.
C1 [Lin, Dai-Zhu; Kao, Yu-Chien] Taipei Med Univ, Coll Med, Taipei, Taiwan.
   [Chen, Chiehfeng; Wang, Hsian-Jenn; Chiu, Wen-Kuan] Taipei Med Univ, Taipei Municipal Wanfang Hosp, Div Plast Surg, Dept Surg, Taipei, Taiwan.
   [Chen, Chiehfeng] Taipei Med Univ, Dept Publ Hlth, Taipei, Taiwan.
   [Chen, Chiehfeng] Taipei Med Univ, Cochrane Taiwan, Taipei, Taiwan.
   [Chiu, Wen-Kuan] Taipei Med Univ, Sch Med, Dept Surg, Coll Med, Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Municipal
   WanFang Hospital; Taipei Medical University; Taipei Medical University;
   Taipei Medical University
RP Chen, CH; Chiu, WK (通讯作者)，Taipei Med Univ, Div Plast Surg, Dept Surg, Wan Fang Hosp,Sch Med,Coll Med, 111 Xinglong Rd,Sec 3, Taipei 11696, Taiwan.
EM clifchen@tmu.edu.tw; doc20463@gmail.com
OI Chen, Chiehfeng/0000-0002-1595-6553
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NR 60
TC 25
Z9 27
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2021
VL 18
IS 1
BP 112
EP 123
DI 10.1111/iwj.13500
EA NOV 2020
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QE1EZ
UT WOS:000592097500001
PM 33236845
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Brownhill, VR
   Huddleston, E
   Bell, A
   Hart, J
   Webster, I
   Hardman, MJ
   Wilkinson, HN
AF Brownhill, Varuni R.
   Huddleston, Elizabeth
   Bell, Andrea
   Hart, Jeffrey
   Webster, Iain
   Hardman, Matthew J.
   Wilkinson, Holly N.
TI Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy
   During In Vivo Porcine Wound Healing
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE NPWT; porcine; wound healing; pressure
ID VACUUM-ASSISTED CLOSURE; NONHEALING WOUNDS; FOAM; EXPRESSION;
   MANAGEMENT; TRAUMA
AB Objective: Traditional negative pressure wound therapy (tNPWT) systems can be large and cumbersome, limiting patient mobility and adversely affecting quality of life. PICO (TM), a no canister single-use system, offers a lightweight, portable alternative to tNPWT, with improved clinical performance. The aim of this study was to determine the potential mechanism(s) of action of single-use NPWT (sNPWT) versus tNPWT.
   Approach: sNPWT and tNPWT were applied to an in vivo porcine excisional wound model, following product use guidelines. Macroscopic, histological, and biochemical analyses were performed at defined healing time points to assess multiple aspects of the healing response.
   Results: Wounds treated with single-use negative pressure displayed greater wound closure and increased reepithelialization versus those treated with traditional negative pressure. The resulting granulation tissue was more advanced with fewer neutrophils, reduced inflammatory markers, more mature collagen, and no wound filler-associated foreign body reactions. Of note, single-use negative pressure therapy failed to induce wound edge epithelial hyperproliferation, while traditional negative pressure therapy compromised periwound skin, which remained inflamed with high transepidermal water loss; features not observed following single-use treatment.
   Innovation: Single-use negative pressure was identified to improve multiple aspects of healing versus traditional negative pressure treatment.
   Conclusion: This study provides important new insight into the differing mode of action of single-use versus traditional negative pressure and may go some way to explaining the improved clinical outcomes observed with single-use negative pressure therapy.
C1 [Brownhill, Varuni R.; Huddleston, Elizabeth; Webster, Iain] TJ Smith & Nephew Ltd, Kingston Upon Hull, N Humberside, England.
   [Bell, Andrea; Hart, Jeffrey] Cica Biomed Ltd, Knaresborough, England.
   [Hardman, Matthew J.; Wilkinson, Holly N.] Univ Hull, Hull York Med Sch, Ctr Atherothrombosis & Metab Dis, Kingston Upon Hull, N Humberside, England.
C3 University of Hull; University of York - UK
RP Hardman, MJ (通讯作者)，Univ Hull, Hull York Med Sch, Ctr Atherothrombosis & Metab Dis, Castle Hill Hosp, Daisy Bldg,2nd Floor, Kingston Upon Hull HU16 5JQ, N Humberside, England.
EM m.hardman@hull.ac.uk
RI Hardman, Matthew/ABE-4936-2020
FU TJ Smith and Nephew Ltd.; Cica Biomedical Ltd.; University of Hull
FX We would like to thank Benjamin Gardner for assistance with sNPWT device
   pump analysis. This study was funded by TJ Smith and Nephew Ltd. in
   collaboration with the University of Hull and Cica Biomedical Ltd.
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NR 42
TC 27
Z9 31
U1 1
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUL 1
PY 2021
VL 10
IS 7
BP 345
EP 356
DI 10.1089/wound.2020.1218
EA NOV 2020
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA SJ0GO
UT WOS:000592283700001
PM 32633639
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Nguyen, SH
   Defnet, AM
   Pati, BA
   Russell, DM
   Gillern, SM
   Lin, E
   Sullivan, PS
   Yheulon, C
AF Nguyen, Scott H.
   Defnet, Ann M.
   Pati, Brooke A.
   Russell, Dylan M.
   Gillern, Suzanne M.
   Lin, Edward
   Sullivan, Patrick S.
   Yheulon, Christopher
TI Role of Negative Pressure Wound Therapy When Performing Elective Open
   Colectomy
SO SURGICAL INFECTIONS
LA English
DT Article
DE colectomy; negative pressure wound therapy; surgical site infection;
   wound complication; wound vac
ID SURGICAL SITE INFECTIONS; SURGERY
AB Background: The impact of negative pressure wound therapy (NPWT) as an adjunct to colorectal surgery is largely unknown. The purpose of this study was to determine whether NPWT impacts wound complications during elective open colectomy.
   Methods: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) and colectomy targeted procedure databases were queried from 2012-2018 for patients undergoing non-emergent planned open colectomies. Groups were propensity score matched for anastomosis type (ileo-colic, colo-colic, colo-rectal), age, body mass index (BMI), diabetes, smoking, steroid use, wound classification, American Society of Anesthesiologists (ASA) class, operative time, and wound layers closed. Wound complications were defined as superficial surgical site infection (SSI), deep incisional SSI, and dehiscence.
   Results: A total of 15,770 patients were identified; 92 underwent simultaneous NPWT (0.58%). Non-NPWT patients were matched at a 5:1 ratio, producing 460 comparisons. There was no difference in wound complications (8.26% non-NPWT vs. 6.52% NPWT; p = 0.574). In addition, there were no differences in wound complications when only including patients who had NPWT placed over closed skin (9.11% non-NPWT vs. 7.25% NPWT; p = 0.789). On multivariable analysis, NPWT was not associated with wound complications (odds ratio [OR] 0.79; 95% confidence interval [CI], 0.37-1.69).
   Conclusions: Negative pressure wound therapy does not reduce wound complications in open elective colectomies. Large randomized studies and more granular data are needed to ascertain if there is any benefit in select patient populations.
C1 [Nguyen, Scott H.; Pati, Brooke A.; Russell, Dylan M.; Gillern, Suzanne M.; Yheulon, Christopher] Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
   [Defnet, Ann M.; Lin, Edward; Yheulon, Christopher] Emory Univ, Div GI & Gen Surg, Atlanta, GA 30322 USA.
   [Sullivan, Patrick S.] Emory Univ, Div Surg Oncol, Atlanta, GA 30322 USA.
C3 Tripler Army Medical Center; United States Department of Defense; United
   States Army; Emory University; Emory University
RP Nguyen, SH (通讯作者)，Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM scott.h.nguyen.mil@mail.mil
RI ; Yheulon, Christopher/AAS-6917-2020
OI Russell, Dylan/0000-0002-9543-9897; 
CR Austin PC, 2010, AM J EPIDEMIOL, V172, P1092, DOI 10.1093/aje/kwq224
   Bonds AM, 2013, DIS COLON RECTUM, V56, P1403, DOI 10.1097/DCR.0b013e3182a39959
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   Cone MM, 2012, J GASTROINTEST SURG, V16, P1212, DOI 10.1007/s11605-012-1860-3
   DeCarbo WT, 2010, J FOOT ANKLE SURG, V49, P299, DOI 10.1053/j.jfas.2010.01.002
   Gantz O, 2019, AM SURGEON, V85, P142
   Kobayashi M, 2008, WORLD J SURG, V32, P1142, DOI 10.1007/s00268-008-9536-6
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   Randolph J.J., 2014, PRACTICAL ASSESSMENT, V19
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   Tyagi V, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.7394
   Webb MA, 2019, AM J SURG, V217, P948, DOI 10.1016/j.amjsurg.2018.12.019
NR 20
TC 3
Z9 3
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD JUN 1
PY 2021
VL 22
IS 5
BP 562
EP 567
DI 10.1089/sur.2020.183
EA NOV 2020
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA SL7FG
UT WOS:000593364100001
PM 33232647
DA 2026-07-24
ER
PT J
AU Rasilainen, S
   Mentula, P
   Salminen, P
   Koivukangas, V
   Hyöty, M
   Mäntymäki, LM
   Pinta, T
   Haikonen, J
   Rintala, J
   Rantanen, T
   Strander, T
   Leppäniemi, A
AF Rasilainen, Suvi
   Mentula, Panu
   Salminen, Paulina
   Koivukangas, Vesa
   Hyoty, Marja
   Mantymaki, Leena-Mari
   Pinta, Tarja
   Haikonen, Jyrki
   Rintala, Jukka
   Rantanen, Tuomo
   Strander, Tapani
   Leppaniemi, Ari
TI Superior primary fascial closure rate and lower mortality after open
   abdomen using negative pressure wound therapy with continuous fascial
   traction
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Open abdomen; temporary abdominal closure; enteroatmospheric fistula;
   delayed primary fascial closure
ID ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION; MANAGEMENT;
   VACUUM; CLASSIFICATION; FISTULA
AB BACKGROUND
   Open abdomen (OA) is a useful option for treatment strategy in many acute abdominal catastrophes. A number of temporary abdominal closure (TAC) methods are used with limited number of comparative studies. The present study was done to examine risk factors for failed delayed primary fascial closure (DPFC) and risk factors for mortality in patients treated with OA. METHODS
   This study was a multicenter retrospective analysis of the hospital records of all consecutive patients treated with OA during the years 2009 to 2016 at five tertiary referral hospitals and three secondary referral centers in Finland. RESULTS
   Six hundred seventy-six patients treated with OA were included in the study. Vacuum-assisted closure with continuous mesh-mediated fascial traction (VACM) was the most popular TAC method used (N = 398, 59%) followed by VAC (N = 128, 19%), Bogota bag (N = 128, 19%), and self-designed methods (N = 22, 3%). In multivariate analysis, enteroatmospheric fistula and the number of needed TAC changes increased the risk for failed DPFC (odds ratio [OR], 8.9; 95% confidence interval [CI], 6.2-12.8; p < 0.001 and OR, 1.1; 95% CI, 1.0-1.3; p < 0.001, respectively). Instead, VACM and ruptured abdominal aortic aneurysm as cause for OA both decreased the risk for failed DPFC (OR, 0.1; 95% CI, 0.0-0.3; p < 0.001 and OR, 0.2; 95% CI, 0.1-0.7; p = 0.012). The overall mortality rate was 30%. In multivariate analysis for mortality, multiorgan dysfunction (OR, 2.4; 95% CI, 1.6-3.6; p < 0.001), and increasing age (OR, 4.5; 95% CI, 2.0-9.7; p < 0.001) predicted increased mortality. Institutional large annual patient volume (OR, 0.4; 95% CI, 0.3-0.6; p < 0.001) and ileus and postoperative peritonitis in comparison to severe acute pancreatitis associated with decreased mortality (OR, 0.2; 95% CI, 0.1-0.4; p < 0.001; OR, 0.5; 95% CI, 0.3-0.8; p = 0.009). Kaplan-Meier analysis showed increased survival in patients treated with VACM in comparison with other TAC methods (LogRank p = 0.019). CONCLUSION
   We report superior role for VACM methodology in terms of successful primary fascial closure and increased survival in patients with OA.
C1 [Rasilainen, Suvi; Mentula, Panu; Leppaniemi, Ari] Helsinki Univ Hosp, Dept Abdominal Surg, Abdominal Ctr, Helsinki, Finland.
   [Rasilainen, Suvi; Mentula, Panu; Leppaniemi, Ari] Univ Helsinki, Helsinki, Finland.
   [Salminen, Paulina; Strander, Tapani] Univ Turku, Turku Univ Hosp, Div Digest Surg & Urol, Dept Surg, Turku, Finland.
   [Salminen, Paulina; Haikonen, Jyrki; Strander, Tapani] Satakunta Cent Hosp, Dept Surg, Pori, Finland.
   [Koivukangas, Vesa] Oulu Univ Hosp, Dept Abdominal Surg, Oulu, Finland.
   [Hyoty, Marja; Mantymaki, Leena-Mari] Tampere Univ Hosp, Dept Gastroenterol & Alimentary Tract Surg, Tampere, Finland.
   [Pinta, Tarja] Seinajoki Cent Hosp, Dept Surg, Seinajoki, Finland.
   [Rintala, Jukka] Lapland Cent Hosp, Dept Surg, Rovaniemi, Finland.
   [Rantanen, Tuomo] Univ Eastern Finland, Inst Clin Med, Kuopio Univ Hosp, Dept Surg, Kuopio, Finland.
C3 University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; University of Turku; Satakunta Central Hospital; University
   of Oulu; Tampere University; Tampere University Hospital; Seinajoki
   Central Hospital; University of Eastern Finland; University of Eastern
   Finland Hospital; Kuopio University Hospital
RP Rasilainen, S (通讯作者)，Jorvi Hosp, HUCH Abdominal Ctr, Turuntie 150, Espoo 02740, Finland.
EM suvi.rasilainen@hus.fi
RI Salminen, Paulina/ABB-8883-2020; Mentula, Panu/H-9025-2019; Leppäniemi,
   Ari/GQZ-7991-2022
OI Salminen, Paulina/0000-0001-6435-9264; Mentula,
   Panu/0000-0002-6516-3797; Rintala, Jukka/0000-0003-1865-8444; 
FU Helsinki University Hospital Research grant for emergency abdominal
   surgery
FX This study was financially supported by a Helsinki University Hospital
   Research grant for emergency abdominal surgery.
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NR 22
TC 16
Z9 20
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD DEC
PY 2020
VL 89
IS 6
BP 1136
EP 1142
DI 10.1097/TA.0000000000002889
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA OZ3WN
UT WOS:000594860700033
PM 32701909
OA Green Submitted, Green Accepted
DA 2026-07-24
ER
PT J
AU Wang, YH
   Hao, DJ
   Qian, LX
   He, X
   Meng, YB
   Wang, B
AF Wang, Yuhang
   Hao, Dingjun
   Qian, Lixiong
   He, Xin
   Meng, Yibin
   Wang, Biao
TI Esophageal perforation following pedicle screw placement for the
   treatment of upper thoracic spinal tuberculosis: a case report and
   review of the literature
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Review
DE Upper thoracic spinal tuberculosis; Esophageal perforation; Esophageal
   fistula; Pedicle screw; Infection
ID ADOLESCENT IDIOPATHIC SCOLIOSIS; ACCURACY; COMPLICATIONS; MANAGEMENT;
   SURGERY
AB BackgroundThe technique of posterior pedicle screw fixation has already been widely applied in the treatment of upper thoracic spinal tuberculosis. However, lesions of tuberculosis directly invade the vertebrae and surrounding soft tissues, which increases the risk of esophageal perforation induced by the posterior pedicle screw placement. Herein, we report the first case of esophageal perforation following pedicle screw placement in the upper thoracic spinal tuberculosis, and describe the underlying causes, as well as the treatment and prognosis.Case presentationA 48-year-old female patient with upper thoracic spinal tuberculosis presented sputum-like secretions from the wound after she was treated with one-stage operation through the posterolateral approach. Endoscopy was immediately conducted, which confirmed that the patient complicated with postoperative esophageal perforation caused by screws. CT scan showed that the right screw perforated the anterior cortex of the vertebrae and the esophagus at the T4 level. Fortunately, mediastinal infection was not observed. The T4 screw was removed, Vacuum Sealing Drainage (VSD) was performed, and jejunum catheterization was used for enteral nutrition. After continuous treatment with sensitive antibiotics for 2.5months and 5 times of VSD aspiration, the infected wound recovered gradually. With 18-month follow-up, the esophagus healed well, without symptoms of dysphagia and stomach discomfort, and CT scan showed that T2-4 had complete osseous fusion without sequestrum.ConclusionTuberculosis increases the risk of postoperative esophageal perforation in a certain degree for patients with upper thoracic tuberculosis. The damages to esophagus during the operation should be prevented. The screws with the length no more than 30mm should be selected. Moreover, close monitoring after operation should be conducted to help the early identification, diagnosis and treatment, which could help preventing the adverse effects induced by the delayed diagnosis and treatment of esophageal perforation.
C1 [Wang, Yuhang; Hao, Dingjun; Qian, Lixiong; He, Xin; Meng, Yibin; Wang, Biao] Xi An Jiao Tong Univ, Honghui Hosp, Dept Spine Surg, Coll Med, 76 Nanguo Rd, Xian 710054, Shaanxi, Peoples R China.
   [Wang, Yuhang] Xian Med Univ, 74 Hanguang North Rd, Xian 710054, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Medical University
RP Wang, B (通讯作者)，Xi An Jiao Tong Univ, Honghui Hosp, Dept Spine Surg, Coll Med, 76 Nanguo Rd, Xian 710054, Shaanxi, Peoples R China.
EM wangbiaowb1987@126.com
OI Wang, Biao/0000-0001-6631-9127
FU Medical Research Project of Xi'an Science and Technology Bureau
   [201805096YX4SF30-4]
FX This work was supported by the Medical Research Project of Xi'an Science
   and Technology Bureau (201805096YX4SF30-4). Fundings include the cost of
   collecting the fellow-up data and publication fee.
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NR 25
TC 4
Z9 5
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD DEC 18
PY 2020
VL 21
IS 1
AR 756
DI 10.1186/s12891-020-03783-4
PG 6
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA OZ7TH
UT WOS:000595123300001
PM 33208114
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Muñoz-Cruzado, VD
   Castro, FJC
   Eguía, AP
   Aguilar, LT
   González, JT
   Puyana, JC
   Ciuró, FP
   Padillo-Ruiz, J
AF Duran Munoz-Cruzado, Virginia
   Calero Castro, Francisco Jose
   Padillo Eguia, Andres
   Tallon Aguilar, Luis
   Tinoco Gonzalez, Jose
   Puyana, Juan Carlos
   Pareja Ciuro, Felipe
   Padillo-Ruiz, Javier
TI Using a bio-scanner and 3D printing to create an innovative custom made
   approach for the management of complex entero-atmospheric fistulas
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PRESSURE WOUND THERAPY; ENTEROATMOSPHERIC FISTULAS; PROLIFERATION;
   EXPERIENCE
AB Enteroatmospheric fistulae are challenging clinical conditions that require surgical expertise and that can result in chronic debilitating conditions placing the patient in a vicious cycle characterized by non healing wounds and malnutrition. They are a complex entity that presents great variability depending on the number, shape, and size of the fistulous orifices, their debit, and the dimensions of the wound. This means that, at present, there is no device that adapts to the anatomical characteristics of each patient and manages to control the spillage of intestinal effluvium from the wound. The aim of this study is to describe the manufacturing technique and to assess the preliminary results of a custom device designed through bioscanner imaging and manufactured using 3D printing for use with negative pressure wound therapy (NPWT) in the management of enteroatmospheric fistula. A proof of concept is given, and the design of the device is presented for the first time. After obtaining images of each fistula with a bioscanner, a personalised device was designed for each patient by 3D printing shape of a prism and a hollow base, taking into account the dimensions of the fistulous area in order to perform a floating ostomy to isolate the wound from the debit enteric. The polycaprolactone (PCL) device was placed including inside the fistulous surface and surrounding it with the NPWT system in order to accelerate wound healing.
C1 [Duran Munoz-Cruzado, Virginia; Calero Castro, Francisco Jose; Tallon Aguilar, Luis; Tinoco Gonzalez, Jose; Pareja Ciuro, Felipe; Padillo-Ruiz, Javier] Virgen Rocio Univ Hosp, Div Gen Surg, Manuel Siurot S-N, Seville 41013, Spain.
   [Padillo Eguia, Andres] Univ Seville, Seville, Spain.
   [Puyana, Juan Carlos] Univ Pittsburgh, Div Surg Crit Care Med & Clin Translat Sci, Pittsburgh, PA USA.
C3 Virgen del Rocio University Hospital; University of Sevilla;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Ciuró, FP (通讯作者)，Virgen Rocio Univ Hosp, Div Gen Surg, Manuel Siurot S-N, Seville 41013, Spain.
EM icirugiaurgenciasHUVR@gmail.com
RI ; Durán Muñoz-Cruzado, Virginia María/GYD-4982-2022; Tallon-Aguilar,
   Luis/JHV-1215-2023; Padillo-Ruiz, Javier/AAF-9792-2021; PAREJA CIURO,
   FELIPE/GZM-1224-2022
OI Puyana, Juan Carlos/0000-0003-4284-4693; Durán Muñoz-Cruzado, Virginia
   María/0000-0003-4499-0483; Tallon-Aguilar, Luis/0000-0002-7549-619X;
   Calero Castro, Francisco José/0000-0002-6039-3091; Padillo-Ruiz,
   Javier/0000-0002-1220-0822; PAREJA CIURO, FELIPE/0000-0001-9192-3465
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NR 28
TC 6
Z9 7
U1 0
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 16
PY 2020
VL 10
IS 1
AR 19862
DI 10.1038/s41598-020-74213-7
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA OZ9SW
UT WOS:000595259700002
PM 33199726
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fröschen, FS
   Walter, SG
   Randau, TM
   Gravius, N
   Gravius, S
   Hischebeth, GTR
AF Froeschen, Frank Sebastian
   Walter, Sebastian Gottfried
   Randau, Thomas Martin
   Gravius, Nadine
   Gravius, Sascha
   Hischebeth, Gunnar Thorben Rembert
TI The use of negative pressure wound therapy increases failure rate in
   debridement and implant retention for acute prosthetic joint infection
SO TECHNOLOGY AND HEALTH CARE
LA English
DT Article
DE Revision total joint arthroplasty; PJI; NPWT; reimplantation;
   multi-stage revision; risk factor
ID TOTAL KNEE ARTHROPLASTY; FAILED IRRIGATION; TOTAL HIP; OUTCOMES
AB BACKGROUND: To date only scanty data exist regarding the effect of failed debridement, antibiotics, irrigation and retention of the prostheses (DAIR) and negative pressure wound therapy (NPWT) on the outcome of a subsequent exchange arthroplasty.
   OBJECTIVE: The objective of this study was to determine the success rate of a two- or multi-stage procedure after initial failed DAIR/NPWT in patients with an acute periprosthetic joint infection (PJI) and to evaluate the influence of possible risk factors for treatment failure.
   METHODS: Nineteen consecutive patients with a persisting PJI and ongoing NPWT after treatment of an acute PJI with DAIR of the hip or knee joint from October 2010 to June 2017 were included. All patients were treated according to a structured treatment algorithm after referral to our hospital. The endpoint was a successful reimplantation with absence of signs of infection two years after replantation ("replantation group") or treatment failure ("treatment failure group") in terms of a permanent girdlestone arthroplasty, fistula, amputation or death. A risk factor analysis was performed between the two groups.
   RESULTS: Explantation was performed in 15 cases, amputation in one case, and DAIR/establishment of a fistula in three cases. The treatment success rate after reimplantation in terms of "definitively free of infection" two years after surgery according to Laffer was 36.85% (seven out of 19 patients). Statistical analysis revealed the number of surgeries until wound consolidation (p = 0.007), number of detected bacterial strains (p = 0.041), a polymicrobial PJI (p = 0.041) and detection of a difficult-to-treat organism (p = 0.005) as factors associated with treatment failure. After failed DAIR/NPWT we could detect a significant higher number of different bacterial strains ( p = 0.001).
   CONCLUSIONS: The treatment success rate after failed DAIR and NPWT with 36% is low and associated with a high treatment failure rate (permanent girdlestone arthroplasty, fistula or amputation, death). Thus, the definition of risk factors is crucial. We found that the number of revisions until wound consolidation, a polymicrobial PJI and detection of a difficult-to-treat organisms were risk factors for treatment failure. Furthermore, after failed DAIR/NPWT we could detect a significant higher number of different bacterial strains, with a possible adverse effect on a consecutive exchange.
C1 [Froeschen, Frank Sebastian; Walter, Sebastian Gottfried; Randau, Thomas Martin; Gravius, Nadine; Gravius, Sascha] Univ Hosp Bonn, Dept Orthopaed & Trauma Surg, Sigmund Freud Str 25, D-53127 Bonn, Germany.
   [Gravius, Sascha] Heidelberg Univ, Univ Hosp Mannheim, Orthopaed & Trauma Surg Ctr, Med Fac Mannheim, Mannheim, Germany.
   [Hischebeth, Gunnar Thorben Rembert] Univ Hosp Bonn, Inst Med Microbiol Immunol & Parasitol, Bonn, Germany.
C3 University of Bonn; Ruprecht Karls University Heidelberg; University of
   Bonn
RP Fröschen, FS (通讯作者)，Univ Hosp Bonn, Dept Orthopaed & Trauma Surg, Sigmund Freud Str 25, D-53127 Bonn, Germany.
EM Frank.Froeschen@ukbonn.de
RI Randau, Thomas/AEP-9749-2022
OI Randau, Thomas/0000-0002-5224-9639
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NR 29
TC 6
Z9 6
U1 0
U2 4
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 0928-7329
EI 1878-7401
J9 TECHNOL HEALTH CARE
JI Technol. Health Care
PY 2020
VL 28
IS 6
BP 721
EP 731
DI 10.3233/THC-192095
PG 11
WC Health Care Sciences & Services; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Engineering
GA PA3FR
UT WOS:000595521400013
PM 32444587
DA 2026-07-24
ER
PT J
AU Ren, SY
   Liu, YS
   Zhu, GJ
   Liu, M
   Shi, SH
   Ren, XD
   Hao, YG
   Gao, RD
AF Ren, Shi-Yan
   Liu, Yong-Sheng
   Zhu, Guo-Jian
   Liu, Meng
   Shi, Shao-Hui
   Ren, Xiao-Dong
   Hao, Ya-Guang
   Gao, Rong-Ding
TI Strategies and challenges in the treatment of chronic venous leg ulcers
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Review
DE Chronic venous leg ulcers; Debridement; Compression; Negative pressure
   wound therapy; Autologous split-thickness skin grafting; Hair punch
   graft; Platelet-rich plasma; Advanced wound care therapies
ID HUMAN AMNION/CHORION MEMBRANE; PRESSURE WOUND THERAPY; THICKNESS
   SKIN-GRAFT; PLATELET-RICH PLASMA; VASCULAR FRACTION CELLS; MESENCHYMAL
   STEM-CELL; COMPRESSION THERAPY; FOAM SCLEROTHERAPY; TOPICAL TIMOLOL;
   MANAGEMENT
AB Evaluating patients with chronic venous leg ulcers (CVLUs) is essential to find the underlying etiology. The basic tenets in managing CVLUs are to remove the etiological causes, to address systemic and metabolic conditions, to examine the ulcers and artery pulses, and to control wound infection with debridement and eliminating excessive pressure on the wound. The first-line treatments of CVLUs remain wound care, debridement, bed rest with leg elevation, and compression. Evidence to support the efficacy of silver-based dressings in healing CVLUs is unavailable. Hydrogen peroxide is harmful to the growth of granulation tissue in the wound. Surgery options include a high ligation with or without stripping or ablation of the GSVs depending on venous reflux or insufficiency. Yet, not all CVLUs are candidates for surgical treatment because of comorbidities. When standard care of wound for 4 wk failed to heal CVLUs effectively, use of advanced wound care should be considered based on the available evidence. Negative pressure wound therapy facilitates granulation tissue development, thereby helping closure of CVLUs. Autologous split-thickness skin grafting is still the gold standard approach to close huge CVLUs. Hair punch graft appears to have a better result than traditional hairless punch graft for CVLUs. Application of adipose tissue or placenta-derived mesenchymal stem cells is a promising therapy for wound healing. Autologous platelet-rich plasma provides an alternative strategy for surgery for safe and natural healing of the ulcer. The confirmative efficacy of current advanced ulcer therapies needs more robust evidence.
C1 [Ren, Shi-Yan] China Med Univ, Dept Gen Surg & Vasc Surg, Aviat Gen Hosp, 2 Beiyuan Rd, Beijing 100012, Peoples R China.
   [Liu, Yong-Sheng] Aviat Gen Hosp, Dept Dermatol, Beijing 100012, Peoples R China.
   [Zhu, Guo-Jian] Taian Commun Hosp, Dept Gen Surg, Tai An 271000, Shandong, Peoples R China.
   [Liu, Meng] Tianjin Hexi Hosp, Dept Surg, Tianjin 300202, Tianjin, Peoples R China.
   [Shi, Shao-Hui] China Med Univ, Aviat Gen Hosp, Dept Orthopaed Surg, Beijing 100012, Peoples R China.
   [Ren, Xiao-Dong] Wanquanqu Zhongyi Hosp, Dept Surg, Zhangjiakou 076250, Hebei, Peoples R China.
   [Hao, Ya-Guang] China Med Univ, Aviat Gen Hosp, Dept Med Adm, Beijing 100012, Peoples R China.
   [Gao, Rong-Ding] China Med Univ, Aviat Gen Hosp, Dept Gen Surg, Beijing 100012, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University; China Medical University
RP Ren, SY (通讯作者)，China Med Univ, Dept Gen Surg & Vasc Surg, Aviat Gen Hosp, 2 Beiyuan Rd, Beijing 100012, Peoples R China.
EM rens66@126.com
RI Liu, Menghui/GWZ-2494-2022
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NR 103
TC 33
Z9 40
U1 0
U2 24
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD NOV 6
PY 2020
VL 8
IS 21
DI 10.12998/wjcc.v8.i21.5070
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PA5RI
UT WOS:000595692200001
PM 33269244
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Cao, ZL
   Zhang, F
   Liu, XJ
   Zhang, M
   Ma, YT
AF Cao, Zilong
   Zhang, Fan
   Liu, Xujin
   Zhang, Min
   Ma, Yuntao
TI Treatment of Superficial Incision Dehiscence after Abdominal Surgery by
   Z-Plasty: A Retrospective Case Series
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE abdominal surgery; debridement; dehiscence; negative-pressure wound
   therapy; superficial incision; Z-plasty
ID PRESSURE WOUND THERAPY; RECONSTRUCTION; INFECTION; GROWTH
AB OBJECTIVE: To explore the treatment of superficial incision dehiscence after abdominal surgery by Z-plasty combined with negative-pressure wound therapy.
   METHODS: A retrospective study was performed on seven patients with superficial abdominal incision dehiscence from October 2018 to February 2019. All patients were given systemic antibiotics and nutrition support. During the first stage, surgical debridement with negative-pressure wound therapy was performed. Local Z-plasty was performed in the second stage.
   RESULTS: The incision healed well in all patients, and no infection or necrosis occurred in the flaps. During the follow-up of 7.3 months (range, 5-10 months), no incision rupture or redehiscence occurred.
   CONCLUSIONS: Surgical debridement, negative-pressure wound therapy, and Z-plasty can be used to treat superficial abdominal incision dehiscence and achieve good therapeutic effect and prognosis. Z-plasty can be used as an alternative to direct suture of incisions because of its simplicity and excellent results.
C1 [Cao, Zilong; Zhang, Fan] Qilu Hosp Shandong Univ, Dept Plast & Burn Surg, Jinan, Peoples R China.
   [Cao, Zilong] Chinese Acad Med Sci & Peking Union Med Coll, Plast Surg Hosp, Beijing, Peoples R China.
   [Liu, Xujin] Dept Hepatol, Jinan, Peoples R China.
   [Zhang, Min] Qihe Peoples Hosp, Dezhou, Peoples R China.
   [Ma, Yuntao] Lanzhou Univ, Clin Hosp 2, Lanzhou, Peoples R China.
C3 Shandong University; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College; Lanzhou University
RP Cao, ZL (通讯作者)，Qilu Hosp Shandong Univ, Dept Plast & Burn Surg, Jinan, Peoples R China.; Cao, ZL (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Plast Surg Hosp, Beijing, Peoples R China.
RI Zhang, Min/ACY-2759-2022
FU Key Research and Development Program of Shandong Province
   [2017GSF218048]
FX The present study was supported by grants from the Key Research and
   Development Program of Shandong Province (no. 2017GSF218048). The
   authors have disclosed no other financial relationships related to this
   article. Submitted October 16, 2019; accepted in revised form December
   10, 2019.
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NR 26
TC 1
Z9 1
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2020
VL 33
IS 11
DI 10.1097/01.ASW.0000717224.62688.fa
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA PB0SO
UT WOS:000596038300004
PM 33065688
DA 2026-07-24
ER
PT J
AU Zizzo, M
   Ruiz, CC
   Zanelli, M
   Bassi, MC
   Sanguedolce, F
   Ascani, S
   Annessi, V
AF Zizzo, Maurizio
   Ruiz, Carolina Castro
   Zanelli, Magda
   Bassi, Maria Chiara
   Sanguedolce, Francesca
   Ascani, Stefano
   Annessi, Valerio
TI Damage control surgery for the treatment of perforated acute colonic
   diverticulitis A systematic review
SO MEDICINE
LA English
DT Review
DE damage control; diverticular disease; diverticulitis; open abdomen;
   surgery
ID GENERALIZED PERITONITIS; LAPAROSCOPIC LAVAGE; PRIMARY RESECTION;
   DEFINITIONS; GUIDELINES; MANAGEMENT; SECONDARY; SEPSIS; TRIAL
AB Background: Acute colonic diverticulitis (ACD) complications arise in approximately 8% to 35% patients and the most common ones are represented by phlegmon or abscess, followed by perforation, peritonitis, obstruction, and fistula. In accordance with current guidelines, patients affected by generalized peritonitis should undergo emergency surgery. However, decisions on whether and when to operate ACD patients remain a substantially debated topic while algorithm for the best treatment has not yet been determined. Damage control surgery (DCS) represents a well-established method in treating critically ill patients with traumatic abdomen injuries. At present, such surgical approach is also finding application in non-traumatic emergencies such as perforated ACD. Thanks to a thorough systematic review of the literature, we aimed at achieving deeper knowledge of both indications and short- and long-term outcomes related to DCS in perforated ACD. Methods: We performed a systematic literature review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines. Pubmed/MEDLINE, Embase, Scopus, Cochrane Library, and Web of Science databases were used to search all related literature. Results: The 8 included articles covered an approximately 13 years study period (2006-2018), with a total 359 patient population. At presentation, most patients showed III and IV American Society of Anesthesiologists (ASA) score (81.6%) while having Hinchey III perforated ACD (69.9%). Most patients received a limited resection plus vacuum-assisted closure at first-look while about half entire population underwent primary resection anastomosis (PRA) at a second-look. Overall morbidity rate, 30-day mortality rate and overall mortality rate at follow-up were between 23% and 74%, 0% and 20%, 7% and 33%, respectively. Patients had a 100% definitive abdominal wall closure rate and a definitive stoma rate at follow-up ranging between 0% and 33%. Conclusion: DCS application to ACD patients seems to offer good outcomes with a lower percentage of patients with definitive ostomy, if compared to Hartmann's procedure. However, correct definition of DCS eligible patients is paramount in avoiding overtreatment. In accordance to 2016 WSES (World Society of Emergency Surgery) Guidelines, DCS remains an effective surgical strategy in critically ill patients affected by sepsis/septic shock and hemodynamical unstability.
C1 [Zizzo, Maurizio; Ruiz, Carolina Castro; Annessi, Valerio] Azienda Unita Sanit Locale IRCCS Reggio Emilia, Surg Oncol Unit, Arcispedale Santa Maria Nuova Reggio Emilia, Vale Risorgimento 80, I-42123 Reggio Emilia, Italy.
   [Zizzo, Maurizio; Ruiz, Carolina Castro] Univ Modena & Reggio Emilia, Clin & Expt Med PhD Program, Modena, Italy.
   [Zanelli, Magda] Azienda Unita Sanit Locale IRCCS Reggio Emilia, Pathol Unit, Arcispedale Santa Maria Nuova Reggio Emilia, Reggio Emilia, Italy.
   [Bassi, Maria Chiara] Azienda Unita Sanit Locale IRCCS Reggio Emilia, Arcispedale Santa Maria Nuova Reggio Emilia, Med Lib, Reggio Emilia, Italy.
   [Sanguedolce, Francesca] Azienda Osped Univ Osped Riuniti Foggia, Pathol Unit, Foggia, FG, Italy.
   [Ascani, Stefano] Azienda Osped Santa Maria Terni, Pathol Unit, Terni, Italy.
C3 IRCCS Arcispedale S. Maria Nuova; Universita di Modena e Reggio Emilia;
   IRCCS Arcispedale S. Maria Nuova; IRCCS Arcispedale S. Maria Nuova;
   University of Foggia
RP Zizzo, M (通讯作者)，Azienda Unita Sanit Locale IRCCS Reggio Emilia, Surg Oncol Unit, Arcispedale Santa Maria Nuova Reggio Emilia, Vale Risorgimento 80, I-42123 Reggio Emilia, Italy.
EM zizzomaurizio@gmail.com
RI Castro Ruiz, Carolina/AAC-5742-2022; Annessi, Valerio/AAC-2812-2020;
   Zizzo, Maurizio/AAE-2724-2020; Bassi, Maria Chiara/J-3703-2018; Zanelli,
   Magda/AAS-7631-2020
OI Zizzo, Maurizio/0000-0001-9841-7856; Bassi, Maria
   Chiara/0000-0002-5418-2837; Zanelli, Magda/0000-0002-8733-9933
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NR 35
TC 14
Z9 16
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV 25
PY 2020
VL 99
IS 48
AR e23323
DI 10.1097/MD.0000000000023323
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PB0WH
UT WOS:000596048000043
PM 33235095
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Palmieri, L
   Corallino, D
   Herencia, IEC
   Meoli, F
   Paganini, AM
AF Palmieri, Livia
   Corallino, Diletta
   Herencia, Ingrid Elva Cordova
   Meoli, Francesca
   Paganini, Alessandro M.
TI Endo-SPONGE pulley system for the treatment of chronic anastomotic
   leakage after rectal resection. A case report
SO ANNALI ITALIANI DI CHIRURGIA
LA English
DT Article
DE Anastomotic leakage (AL); Anterior rectal resection; Endo-SPONGE;
   Endoscopic-Interventional radiology; Pulley system
ID TRANSANAL ENDOSCOPIC MICROSURGERY; LOCO-REGIONAL RESECTION;
   VACUUM-ASSISTED CLOSURE; QUALITY-OF-LIFE; ANTERIOR RESECTION; CANCER;
   MANAGEMENT; RECURRENCE; THERAPY; ELRR
AB AIM: Anastomotic leakage (AL) after anterior rectal resection unresponsive to diverting ileostomy is difficult to manage. Endoscopic vacuum-assisted (E-VAC) wound closure system is a new approach based on co-axial sponge positioning under endoscopic control. If the abscess is not co-axial, however, endoscopic positioning is not feasible. Aim is to report an original method of sponge positioning.
   CASE EXPEFUENCE: A 62-year-old woman with chronic AL after anterior rectal resection for cancer was referred. AL had been treated with diverting ileostomy without healing. Due to the peri-rectal abscess anatomy, standard E-VAC positioning was not possible. A combined endoscopic-interventional radiology procedure for Endo-SPONGE (R) (B. Braun Aesculap AG, Germany) positioning was thus employed. Under general anesthesia, a guidewire was passed after small counter-incision on the left gluteus and through the left levator muscle, reaching the anastomotic dehiscence and rectal lumen through the chronic abscess. The guidewire was retrieved through the anus and connected to a long silk thread. By retracting the trans-gluteal guidewire, the silk thread was pulled through the abscess to exit from the gluteal skin incision. A tailored Endo-SPONGE (R) was then connected to the trans-anal silk thread. By pulling on the gluteal silk thread, the sponge was positioned inside the abscess. The silk thread remained in place under a medication for sponge replacements.
   DISCUSSION AND RESULTS: Twelve Endo-SPONGE replacements under sedation were required until AL completely resolved after 35 days.
   CONCLUSION: When traditional endoscopic sponge insertion into AL is not possible, this original "pulley system" proved effective for sponge introduction and replacement.
C1 [Palmieri, Livia; Corallino, Diletta; Herencia, Ingrid Elva Cordova; Meoli, Francesca; Paganini, Alessandro M.] Sapienza Univ, Dept Gen Surg & Surg Specialties Paride Stefanini, Rome, Italy.
C3 Sapienza University Rome
RP Palmieri, L (通讯作者)，Sapienza Univ Rome, Dept Gen Surg & Surg Specialties Paride Stefanini, Azienda Policlin Umberto I, Viale Policlin 155, I-00161 Rome, Italy.
EM livia.palmieri@alice.it
RI Paganini, Alessandro/H-8615-2019
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NR 30
TC 1
Z9 1
U1 0
U2 1
PU EDIZIONI LUIGI POZZI
PI ROME
PA VIA PANAMA 68, 00198 ROME, ITALY
SN 0003-469X
EI 2239-253X
J9 ANN ITAL CHIR
JI Ann. Ital. Chir.
PD SEP-OCT
PY 2020
VL 91
IS 5
BP 538
EP 543
AR PII S0003469X2003328X
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA PC2RU
UT WOS:000596855100014
PM 33295302
DA 2026-07-24
ER
PT J
AU Karakol, P
   Bozkurt, M
AF Karakol, Percin
   Bozkurt, Mehmet
TI Recent strategic approach in postburn extremity scars and contractures
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Burn contractures; dermal scaffolds; negative pressure wound therapy;
   cellular therapy; platelet-rich plasma; fat graft
ID NEGATIVE-PRESSURE DRESSINGS; THICKNESS SKIN-GRAFTS; PLATELET-RICH
   PLASMA; DERMAL SUBSTITUTION; RECONSTRUCTIVE SURGERY; ASSESSMENT SCALE;
   FAT INJECTION; BURN SCAR; CLOSURE; MANAGEMENT
AB This study aims to present the outcomes from current alternative treatment modalities combined with the conventional techniques used in the treatment of burn contractures. Twenty-nine patients were included in the study. Patients were divided into three groups according to the severity of contractures: 1- mild, 2- moderate, and 3- severe. Skin defects that occurred following the incision and scar contracture release were closed with a collagen-elastin acellular dermal matrix (ADM). The split-thickness skin graft was evenly placed on the ADM and fixed with absorbable sutures. The grafts were closed with NPWT (negative pressure wound therapy system) dressings. In platelet-rich plasma (PRP) mild cases as well as moderate and severe PRP cases, stem cell and fat injection were applied. PRP injection was applied to the scar base before the contracture; fat injection and stem cells were applied at the 3rd and 6th months. Preoperative and postoperative range of motion (ROM), Patient and Observer Scars Evaluation Scale (POSAS), and histopathological scores were evaluated. There was a statistically significant decrease in postoperative POSAS scores (p < .05) and a significant increase in the ROM score (p < .05). Histopathological examination revealed an increased postoperative collagen accumulation and organization, increased vascularization, decreased scar tissue thickness and increased subcutaneous tissue thickness. There was no difference in treatment outcomes between the groups.
   Based on the current findings, we conclude that ADM, stem cell-rich fat grafting, and PRP therapies combined with conventional methods could satisfactorily improve functional outcomes in the repair of burn contractures.
C1 [Karakol, Percin; Bozkurt, Mehmet] Hlth Sci Univ, Dept Plast Reconstruct & Aesthet Surg, Bagcilar Educ & Training Hosp, TR-3400 Istanbul, Turkey.
C3 Istanbul Bagcilar Training & Research Hospital
RP Karakol, P (通讯作者)，Hlth Sci Univ, Dept Plast Reconstruct & Aesthet Surg, Bagcilar Educ & Training Hosp, TR-3400 Istanbul, Turkey.
EM ppercin@gmail.com
RI BOZKURT, Mehmet/KFR-6152-2024
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NR 52
TC 8
Z9 11
U1 0
U2 3
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD JUN 1
PY 2021
VL 55
IS 3
BP 153
EP 161
DI 10.1080/2000656X.2020.1856670
EA NOV 2020
PG 9
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA SO9KZ
UT WOS:000598547600001
PM 33315507
OA gold
DA 2026-07-24
ER
PT J
AU Yasuda, JL
   Staffa, SJ
   Clark, SJ
   Ngo, PD
   Zendejas, B
   Hamilton, TE
   Jennings, RW
   Manfredi, MA
AF Yasuda, Jessica L.
   Staffa, Steven J.
   Clark, Susannah J.
   Ngo, Peter D.
   Zendejas, Benjamin
   Hamilton, Thomas E.
   Jennings, Russell W.
   Manfredi, Michael A.
TI Endoscopic incisional therapy and other novel strategies for effective
   treatment of congenital esophageal stenosis
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Endoscopic incisional therapy; Esophageal stent; Esophageal vacuum
   assisted closure
ID CLINICAL CHARACTERISTICS; MANAGEMENT; DISTAL
AB Background & aims: Congenital esophageal stenosis (CES) is an inborn condition of the esophagus that can be refractory to endoscopic dilation. Surgical intervention is not curative, with patients experiencing frequent ongoing need for therapy for anastomotic stricture postoperatively. We hypothesized that novel methods of endoscopic CES management including endoscopic incisional therapy (EIT) would lead to less surgical intervention.
   Methods: We retrospectively reviewed the medical records of all patients with CES treated by our tertiary care center who had at least one endoscopy between July 2007 and July 2019. Statistical comparison of cohorts who underwent advanced endoscopic therapy involving EIT versus traditional endoscopic therapy with balloon dilation was performed. Primary outcome measure was need for surgical intervention.
   Results: Thirty-six patients with CES met inclusion criteria. Thirty-four ever had at least one endoscopic intervention such as balloon dilation, steroid injection, stenting, and/or endoscopic incisional therapy (EIT) at their CES. Esophageal vacuum assisted closure (EVAC) was used for treatment or prevention of esophageal leak. Odds of surgical intervention were significantly lower in the group who received therapeutic endoscopy with EIT (odds ratio (OR) 0.1; p = 0.007). Clinical feeding outcomes were similar in the endoscopic and surgical management groups. Odds of complications after therapeutic endoscopies involving EIT were significantly greater than those without EIT (odds ratio 6.39; 95% confidence interval (2.34, 17.44); p < 0.001), though our rates of esophageal leak significantly decreased over time as our use of EVAC increased (Spearman's rho = -0.884; p = 0.004).
   Conclusion: Complementary endoscopic techniques such as EIT broaden the toolbox of the treating physician and may allow for avoidance of surgery in CES. (c) 2020 Elsevier Inc. All rights reserved.
C1 [Yasuda, Jessica L.; Ngo, Peter D.; Manfredi, Michael A.] Boston Childrens Hosp, Div Gastroenterol Hepatol & Nutr, Boston, MA USA.
   [Clark, Susannah J.; Zendejas, Benjamin; Hamilton, Thomas E.; Jennings, Russell W.] Boston Childrens Hosp, Dept Gen Surg, Boston, MA USA.
   [Staffa, Steven J.] Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital
RP Yasuda, JL (通讯作者)，300 Longwood Ave, Boston, MA 02115 USA.
EM Jessica.Yasuda@childrens.harvard.edu
RI Hamilton, Thomas/GQB-4837-2022
OI Clark, Susannah/0000-0003-4873-0582
CR Amae S, 2003, J PEDIATR SURG, V38, P565, DOI 10.1053/jpsu.2003.50123
   Bocus P, 2011, GASTROINTEST ENDOSC, V74, P204, DOI 10.1016/j.gie.2011.01.071
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NR 15
TC 18
Z9 26
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD NOV
PY 2020
VL 55
IS 11
BP 2342
EP 2347
DI 10.1016/j.jpedsurg.2020.01.013
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA PF3PI
UT WOS:000598970400014
PM 32057439
DA 2026-07-24
ER
PT J
AU Chen, LY
   Hou, JD
   Peng, CZ
AF Chen, Li-Yung
   Hou, Jin-De
   Peng, Chian-Ze
TI Bidirectional Irrigation System to Treat a Difficult Wound: A Case
   Series
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE difficult wound; negative-pressure wound therapy; therapeutic
   irrigation; healing rate; infection; case report
ID NEGATIVE-PRESSURE; METAANALYSIS; THERAPY; UPDATE; MANAGEMENT; INFECTION;
   BIOFILMS; DRAINAGE
AB Aims
   To date, there is no distinct principle determining whether to use irrigation under negative-pressure wound therapy (NPWT). We developed a new economical device to manage difficult wounds, employing 1 of 2 techniques depending on the wound condition.
   Methods
   This case series study was conducted in 12 patients with difficult wound, from 2017 to 2018. Four patients were treated with Type A bidirectional irrigation system (wound irrigation), while 8 patients were treated with Type B bidirectional irrigation system (wound irrigation combined with NPWT).
   Results
   In the Type A device group, inflammatory profiles in case I, case IV, and case VIII were not monitored due to the stability of their wound. The mean recovery period was 3.75 weeks (2-8 weeks), with decreases in 100% healing rate. In the Type B device group, we noted an average of 71% reduction in inflammatory profiles. All patients' infections were resolved or were healing, and 7 patients recovered satisfactorily. The recovery period ranged from 4 to 17 weeks, with a median value of 7 weeks.
   Conclusion
   Bidirectional irrigation system decreases secondary infections and complications, and increases the healing rate in patients with difficult wound.
C1 [Chen, Li-Yung] Kaohsiung Armed Forces Gen Hosp, Gangshan Branch, Kaohsiung, Taiwan.
   [Hou, Jin-De] Hualien Armed Forces Gen Hosp, Natl Def Med Ctr, Hualien, Taiwan.
   [Peng, Chian-Ze] Taipei Vet Gen Hosp, Taipei, Taiwan.
   [Peng, Chian-Ze] Taipei Vet Gen Hosp, Yuan Shan & Su Ao Branch, Yilan, Taiwan.
   [Peng, Chian-Ze] Triserv Gen Hosp, Natl Def Med Ctr, Taipei, Taiwan.
C3 National Defense Medical University; Taipei Veterans General Hospital;
   Taipei Veterans General Hospital; Tri-Service General Hospital; National
   Defense Medical University
RP Chen, LY (通讯作者)，Kaohsiung Armed Forces Gen Hosp, Dept Surg, Gangshan Branch, 1,Dayi 2nd Rd, Kaohsiung 820, Taiwan.
EM chenlijon.tw@yahoo.com.tw
OI Chen, Li-Yung/0000-0002-4311-3107
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   Zhadan O, 2018, AESTHET SURG J, V38, P265, DOI 10.1093/asj/sjx171
NR 26
TC 0
Z9 0
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2023
VL 22
IS 1
BP 156
EP 162
AR 1534734620974551
DI 10.1177/1534734620974551
EA DEC 2020
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8O4OX
UT WOS:000599541200001
PM 33295247
DA 2026-07-24
ER
PT J
AU Cheng, J
   Zhang, Q
   Feng, SM
   Wu, XD
   Huo, WL
   Ma, Y
   Cai, JP
   Liu, MM
AF Cheng, Jian
   Zhang, Qi
   Feng, Shiming
   Wu, Xiaodong
   Huo, Weiling
   Ma, Yong
   Cai, Jianping
   Liu, Mingming
TI Clover-Style Fasciocutaneous Perforator Flap for Reconstruction of
   Massive Sacral Pressure Sores
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE sacral pressure sores; fasciocutaneous flap; perforator flap;
   reconstruction
ID SUPERIOR GLUTEAL ARTERY; ANGIOGRAPHY; PRINCIPLES; ANATOMY
AB Background
   As a common complication of the long-term bedridden patients, pressure sore is a great challenge for surgeons. The purpose of this study was to explore the surgical method of using a clover-style fasciocutaneous perforator flap raised on the buttocks for the treatment of massive sacral pressure sores and report the clinical outcomes. Methods
   The study included 15 patients from January 2015 to June 2017 with an average age of 52.87 years (range, 32-73 years). The size of the sacral pressure sores ranged from 10 cm x 13 cm to 18 cm x 20 cm. The defects were reconstructed using a fasciocutaneous perforator flap raised on the buttocks after debridement and vacuum sealing drainage treatment for 1 to 2 weeks. All the donor areas were sutured directly. Results
   All flaps survived completely; 13 patients achieved healing by primary intention, and the other 2 patients achieved healing by secondary intention. At the mean follow-up period of 20.8 months (range, 12-46 months), the appearance of the flap, including its texture and color, in all patients was satisfactory. No patients had deep infection, necrosis, or shrinkage of the flap during the follow-up period. One patient had a recurrent bedsore during the 2-year follow-up. Conclusions
   The clover-style fasciocutaneous perforator flap is ideal for the reconstruction of massive sacral pressure sores because it is a relatively simple procedure and results in good appearance and function, few complications, and a low recurrence rate.
C1 [Cheng, Jian; Feng, Shiming; Wu, Xiaodong; Huo, Weiling] Xuzhou Cent Hosp, Dept Orthoped, Xuzhou, Jiangsu, Peoples R China.
   [Cheng, Jian; Zhang, Qi; Ma, Yong; Cai, Jianping] Nanjing Univ Chinese Med, Grad Sch, Nanjing, Peoples R China.
   [Zhang, Qi] Nanjing Univ Chinese Med, Xuzhou TCM Hosp, Dept Oncol, Xuzhou, Jiangsu, Peoples R China.
   [Liu, Mingming] Second Peoples Hosp Lianyungang, Dept Orthoped, 161 Xingfu South Rd, Lianyungang, Jiangsu, Peoples R China.
C3 Southeast University - China; Nanjing University of Chinese Medicine;
   Nanjing University of Chinese Medicine
RP Liu, MM (通讯作者)，Second Peoples Hosp Lianyungang, Dept Orthoped, 161 Xingfu South Rd, Lianyungang, Jiangsu, Peoples R China.
EM drchengjian@126.com; zhangqixueye@163.com; lanbing3399@sina.com;
   875105325@qq.com; 583118401@qq.com; 407456262@qq.com;
   caijp_0410@163.com; drorthop@126.com
RI ; Cai, Jianping/OHR-4475-2025
OI Cheng, Jian/0000-0001-8100-4182; 
CR Ahmadzadeh R, 2007, PLAST RECONSTR SURG, V120, P1551, DOI 10.1097/01.prs.0000282098.61498.ee
   Behan F, 2003, ANZ J SURG, V73, P112, DOI 10.1046/j.1445-2197.2003.02638.x
   Chang CK, 2017, INT WOUND J, V14, P1170, DOI 10.1111/iwj.12781
   Chen WJ, 2016, SAUDI MED J, V37, P1140, DOI 10.15537/smj.2016.10.15682
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NR 24
TC 3
Z9 6
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JAN
PY 2021
VL 86
IS 1
BP 62
EP 66
DI 10.1097/SAP.0000000000002442
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA PG4NX
UT WOS:000599714800014
PM 32487808
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Holloway, JJ
   Lauer, K
   Kansal, N
   Bongaard, F
   Miller, A
AF Holloway, Janell J.
   Lauer, Kimberly
   Kansal, Nikhil
   Bongaard, Frederic
   Miller, Ashley
TI A Novel Approach to Limb Salvage: Healing Transmetatarsal Amputations
   without a Viable Plantar Flap
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 44th Vascular Annual Winter Meeting of the Society-for-Vascular-Surgery
   and Vascular-and-Endovascular-Surgery-Society (VESS)
CY JAN 30-FEB 02, 2020
CL Steamboat Springs, CO
SP Vasc & Endovascular Surg Soc, Soc Vasc Surg
ID CONTEMPORARY SERIES; MORTALITY; MORBIDITY
AB Background: The lack of a viable plantar flap in patients undergoing transmetatarsal amputation has been considered an indication for below-knee amputation (BKA). In an effort to reduce limb loss in this patient population, we sought to review our experience with transmetatarsal amputation salvage in patients with an open, guillotine transmetatarsal amputation. We hypothesized that performing a transmetatarsal amputation without a viable flap would extend time of independent ambulation and improve limb salvage.
   Methods: This is a retrospective review of 27 consecutive patients who did not have a viable plantar flap and who underwent an open, guillotine transmetatarsal amputation. Patients presented with a nonviable plantar flap due to either extensive tissue loss on initial presentation, or secondary transmetatarsal amputation (TMA) flap necrosis. Patients initially underwent an open, guillotine TMA for control of infection and debridement of nonviable tissue. To achieve best results, during procedure, the metatarsals were resected to be as flush with soft tissue as possible. Once infection was resolved and all nonviable tissue debrided, negative pressure wound therapy (NPWT) was applied to the open wound. NPWT was continued until a base of granulation tissue covered the previously exposed bone. Wound closure was obtained by either the application of a split-thickness skin graft (STSG) or through continued NPWT allowing the wound to heal by secondary intention.
   Results: Between January 2016 and December 2018, there were 27 open TMAs performed in 27 patients. Two patients did not granulate sufficiently and underwent BKA. Fourteen patients underwent STSG for closure, whereas 11 patients continued with NPWT. In the STSG group, 12 (86%) of the patients are healed, with a median time to complete healing of 75 days (range 28-330 days); the remaining 2 are ambulatory and undergoing continued wound care. In the 11 patients who did not receive STSG, 7 (64%) are healed with a median time to heal of 165 days. Of the remaining 4 patients in this group, 3 are ambulatory and still undergoing wound care, one was lost to follow-up. Overall, 19 patients (70%) have completely healed with a median time to heal of 82 days.
   Conclusions: Limb salvage in patients with a nonviable plantar flap for TMA is possible and should be a considered procedure. This technique has the potential to improve functional outcomes and limb salvage in patients who might otherwise undergo BKA.
C1 [Holloway, Janell J.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Holloway, Janell J.] Charles R Drew Univ Med & Sci, Coll Med, 1621 E 120th St, Los Angeles, CA 90059 USA.
   [Lauer, Kimberly; Kansal, Nikhil; Bongaard, Frederic; Miller, Ashley] Harbor UCLA Med Ctr, Dept Surg, Torrance, CA 90509 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; Charles R. Drew University of Medicine & Science;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center
RP Miller, A (通讯作者)，Harbor UCLA, Dept Surg, 1000 W Carson St, Torrance, CA 90509 USA.
EM amiller@dhs.lacounty.gov
CR Adams CT, 2019, KNEE AMPUTATION BKA
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NR 13
TC 5
Z9 5
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD JAN
PY 2021
VL 70
BP 51
EP 55
DI 10.1016/j.avsg.2020.08.098
PG 5
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA PG6HC
UT WOS:000599833300007
PM 32866571
DA 2026-07-24
ER
PT J
AU Zhang, LP
   Weng, TT
   Wu, P
   Li, Q
   Han, CM
   Wang, XG
AF Zhang, Liping
   Weng, Tingting
   Wu, Pan
   Li, Qiong
   Han, Chunmao
   Wang, Xingang
TI The Combined Use of Negative-Pressure Wound Therapy and Dermal
   Substitutes for Tissue Repair and Regeneration
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; CELL-SHAPE; CLINICAL EFFECTIVENESS; ENHANCED
   ANGIOGENESIS; IN-VIVO; SKIN; RECONSTRUCTION; SCAFFOLDS; DEFECTS; BURNS
AB In clinical practice, skin defects occur frequently due to various kinds of acute and chronic diseases. The standard treatment for these wounds is autografting, which usually results in complications such as scar formation and new wounds at donor sites. The advent of dermal substitutes has provided a novel method for wound repair, and rapid angiogenesis of the dermal substitutes is crucial for the graft to take. At present, many strategies have been developed to improve the process of vascularisation, some of which have shown promising potentials, but they could be very far from clinical applications. Most recently, negative-pressure wound therapy (NPWT) has been used extensively in clinical practice for wound care and management. It has been reported that NPWT reduces the time required for vascular ingrowth into the dermal substitute and improves graft take, indicating great potentials for wound repair. This article presents a comprehensive overview of the combined use of NPWT and dermal substitutes for tissue repair and regeneration. Relative concerns and prospects are also discussed.
C1 [Zhang, Liping; Weng, Tingting; Wu, Pan; Li, Qiong; Han, Chunmao; Wang, Xingang] Zhejiang Univ, Coll Med, Affiliated Hosp 2, Dept Burns & Wound Care Ctr, Hangzhou 310009, Peoples R China.
   [Weng, Tingting] Zhejiang Univ, Coll Med, Hangzhou 310000, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Wang, XG (通讯作者)，Zhejiang Univ, Coll Med, Affiliated Hosp 2, Dept Burns & Wound Care Ctr, Hangzhou 310009, Peoples R China.
EM lpzhang_246@163.com; 1347543482@qq.com; wupan_lhl@zju.edu.cn;
   liq2007.best@163.com; zrssk@zju.edu.cn; wangxingang8157@zju.edu.cn
FU National Natural Science Foundation of China [817720691, 8140159];
   National Key Research and Development Program of China [2016YFC1100803];
   Zhejiang Provincial Medical and Health Discipline Platform Project
   [2018RC035]
FX This work was financially supported by the National Natural Science
   Foundation of China (817720691 and 8140159), the National Key Research
   and Development Program of China (2016YFC1100803), and Zhejiang
   Provincial Medical and Health Discipline Platform Project (2018RC035).
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NR 62
TC 27
Z9 28
U1 0
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD DEC 4
PY 2020
VL 2020
AR 8824737
DI 10.1155/2020/8824737
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA PG7CJ
UT WOS:000599889000003
PM 33344649
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hämäläinen, E
   Laurikka, J
   Huhtala, H
   Järvinen, O
AF Hamalainen, E.
   Laurikka, J.
   Huhtala, H.
   Jarvinen, O.
TI Vacuum assistance therapy as compared to early reconstructive treatment
   in deep sternal wound infection
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Cardiac surgery; deep sternal wound infection; DSWI; mediastinitis;
   pressure therapy; candida
ID CLOSURE THERAPY; MEDIASTINITIS; IMPACT
AB Background and Aims:
   Deep sternal wound infection is a major concern after cardiac surgery. This study describes the incidence of postoperative deep sternal wound infections after cardiac surgery and compares two available treatment modalities.
   Materials and Methods:
   In Tampere University Hospital, 7973 open heart operations were performed between 2007 and 2016. Patients treated for a postoperative deep sternal wound infection were categorized in two groups based on treatment: revision surgery with early reconstruction (revision group; 74 patients) or vacuum-assisted closure treatment (VAC group; 55 patients). The end points in comparisons were overall mortality and hospitalization time.
   Results:
   A total of 129 patients (1.6%) developed a postoperative deep sternal wound infection. The 30-day mortality rates were 8.1% and 3.6%, the 90-day mortality rates were 15.5% and 18.2%, and the 1-year mortality rates were 17.6% and 23.6% for the revision and VAC group, respectively. There was no statistically significant difference in mortality rates. The hospital stay was 18 days in the revision group and 38 days in the VAC group (p < 0.001). The secondary intensive care unit stay was longer in the VAC group (median 1 vs 4, p = 0.011). The most common pathogens isolated in the first reoperation were coagulase-negative staphylococci (33.8% and 41.8%, respectively; p = 0.366), and positive candida findings were more common in the VAC group (4.1% vs 37.0 %, p < 0.001).
   Conclusion:
   Vacuum-assisted closure treatment induces an inferior outcome in terms of fungal infections, treatment times, and the number of reoperations.
C1 [Hamalainen, E.; Laurikka, J.] Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33500, Finland.
   [Laurikka, J.; Jarvinen, O.] Tampere Heart Hosp, Dept Cardiothorac Surg, Tampere, Finland.
   [Huhtala, H.] Tampere Univ, Fac Social Sci, Tampere, Finland.
C3 Tampere University; Tampere University
RP Hämäläinen, E (通讯作者)，Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33500, Finland.
EM eero.hamalainen@tuni.fi
RI ; LAURIKKA, Jari/F-2010-2014
OI Hämäläinen, Eero/0000-0003-1230-8654; LAURIKKA,
   Jari/0000-0001-7253-6048; Huhtala, Heini/0000-0003-1372-430X
CR Baillot R, 2010, EUR J CARDIO-THORAC, V37, P880, DOI 10.1016/j.ejcts.2009.09.023
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NR 14
TC 15
Z9 18
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD JUN
PY 2021
VL 110
IS 2
SI SI
BP 248
EP 253
AR 1457496920979289
DI 10.1177/1457496920979289
EA DEC 2020
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TE4GX
UT WOS:000599898500001
PM 33327852
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Iqbal, FM
   Reid, JP
   Vidya, R
AF Iqbal, Fahad M.
   Reid, Jeremy P.
   Vidya, Raghavan
TI Oncoplastic breast surgery: the role of negative pressure wound therapy
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE breast; negative pressure wound therapy; surgical wound infection; wound
   healing; wound infection; wounds
ID ASSISTED CLOSURE THERAPY; CHRONIC LEG ULCERS; SUBATMOSPHERIC PRESSURE;
   DRESSINGS; METALLOPROTEINASES; RECONSTRUCTION; METAANALYSIS; PREVENTION;
   EXPOSURE; FLUID
AB Wound-related problems following breast surgery are common. Delayed wound healing can lead to poor cosmesis and, among breast cancer patients, can result in delays in receiving adjuvant treatment. The aim of our review was to look at the literature in relation to the role of negative pressure wound therapy in oncoplastic breast surgery, as at the time of writing, there is no consensus on the use of prophylactic negative pressure dressings in closed wounds following breast surgery.
   Declaration of interest: The authors have no conflicts of interest to declare.
C1 [Iqbal, Fahad M.] St George Hosp, London, England.
   [Reid, Jeremy P.; Vidya, Raghavan] Royal Wolverhampton Hosp NHS Trust Hosp, Wolverhampton, England.
   [Vidya, Raghavan] Univ Birmingham, Birmingham, W Midlands, England.
C3 City St Georges, University of London; University of Birmingham
RP Vidya, R (通讯作者)，Royal Wolverhampton Hosp NHS Trust Hosp, Wolverhampton, England.; Vidya, R (通讯作者)，Univ Birmingham, Birmingham, W Midlands, England.
EM raghavan.vidya@nhs.net
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NR 34
TC 7
Z9 8
U1 0
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2020
VL 29
IS 12
BP 777
EP 780
DI 10.12968/jowc.2020.29.12.777
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA PG9TR
UT WOS:000600069200012
PM 33320749
DA 2026-07-24
ER
PT J
AU Kang, YQ
   Wu, YW
   Ma, YH
   Liu, J
   Gu, J
   Zhou, M
   Wang, YP
   Lin, F
   Rui, YJ
AF Kang, Yongqiang
   Wu, Yongwei
   Ma, Yunhong
   Liu, Jun
   Gu, Jun
   Zhou, Ming
   Wang, Yapeng
   Lin, Fang
   Rui, Yongjun
TI "Primary free-flap tibial open fracture reconstruction with the
   Masquelet technique" and internal fixation
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE Lower extremity trauma; Free-flap; Reconstruction; Masquelet; Open
   fracture; Gustilo grade III
ID INDUCED MEMBRANE; DEFECTS; MANAGEMENT; INFECTION; TRAUMA; TIME
AB Background: Grade III open fractures of the lower extremity are serious injuries and are difficult to reconstruct. The optimal treatment for such injuries is unclear. We aimed to determine the safety and efficacy of orthoplastic reconstruction, using a primary free anterolateral thigh flap combined with the Masquelet technique and internal fixation for Gustilo grade IIIB/C open tibial fractures.
   Methods: From April 2018 to April 2019, 15 patients, ranging from 19 to 72 years old, with Gustilo grade IIIB/C open fractures were treated using a primary free anterolateral thigh flap combined with the Masquelet technique and internal fixation. This involved wound debridement and removal of free bone fragments, followed by bone cement packing of the defect, external fixation, and vacuum sealing drainage treatment. The final stage involved switching from external to internal fixation and wound repair using a free anterolateral thigh flap. Repair time ranged from 2 to 7 days. Flap size ranged from 25 x 15 cm(2) to 13 x 7cm(2). Hospital stay ranged from 11 to 50 days (mean, approximately 33.3 days). Bone cement was removed after 6-19 weeks and replaced with autogenic cancellous bone.
   Results: All flaps survived without incident. One patient experienced a wound infection, but there were no deep infections. For all patients, bone union was achieved after 4 to 7 months.
   Conclusion: The use of a primary free anterolateral thigh flap combined with the Masquelet technique and internal fixation is a safe and effective procedure for reconstruction of Gustilo grade IIIB/C open fractures. (C) 2020 The Authors. Published by Elsevier Ltd.
C1 [Kang, Yongqiang; Wu, Yongwei; Ma, Yunhong; Liu, Jun; Gu, Jun; Zhou, Ming; Wang, Yapeng; Lin, Fang; Rui, Yongjun] Soochow Univ, Dept Traumat Orthoped, Wuxi Peoples Hosp 9, Wuxi, Jiangsu, Peoples R China.
C3 Soochow University - China
RP Rui, YJ (通讯作者)，Soochow Univ, Wuxi Peoples Hosp 9, 999 Liangxi Rd, Wuxi 214062, Jiangsu, Peoples R China.
EM wxswkryj123@126.com
RI Rui, Yongjun/PFI-5346-2025
FU Construction target of clinical medical center in Wuxi; General Project
   of Jiangsu Provincial Department of Health [H077]
FX This work was supported by the Construction target of clinical medical
   center in Wuxi, and by the General Project of Jiangsu Provincial
   Department of Health (H077).
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NR 19
TC 28
Z9 45
U1 0
U2 10
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD DEC
PY 2020
VL 51
IS 12
BP 2970
EP 2974
DI 10.1016/j.injury.2020.10.039
PG 5
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA PH2CT
UT WOS:000600228400037
PM 33097199
OA hybrid
DA 2026-07-24
ER
PT J
AU Enescu, DM
   Stoicescu, S
   Tomita, M
   Nacea, I
   Ionita, D
   Tatar, R
AF Enescu, Dan Mircea
   Stoicescu, Simona
   Tomita, Maria
   Nacea, Iulia
   Ionita, Dan
   Tatar, Raluca
TI Management of lower extremity traumatic injuries with negative pressure
   wound therapy: Experience of a pediatric plastic surgery department
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Negative Pressure Wound Therapy; Pediatric trauma; Lower extremity; Skin
   and soft tissue defects
ID CHILDREN; INFANTS; FLAP; SKIN
AB Introduction: Extensive lower limb traumatic injuries are particularly challenging when they associate skin and soft tissue defects, moreover when the patient is a child. In view of more frequent recommendations and reports of negative pressure wound therapy (NPWT) use for severe trauma and extensive soft tissue defects of the lower extremity, we aimed at reviewing the indications and outcomes of this technique in our pediatric plastic surgery department.
   Method: We performed a retrospective study for the period 2016-2019, in order to identify patients having suffered injuries of the ankle and foot, for who NPWT was used in the therapeutic protocol.
   Results: For the study period we identified a total of 9 children with ankle and foot injuries who had NPWT in their therapeutic protocol. The average age was 10 years (range 3 years 5 months to 14 years 4 months) and 8 of them were pedestrians, victims of traffic accidents. Five patients presented with associated injuries and fractures in other anatomic locations. NPWT was started 1-3 days after admission and it was used in average for 21.77 days, with good results in all cases. For 8 patients NPWT was sufficient to contract the wound and cover exposed bone and tendons before closing with split thickness skin graft (STSG). One patient needed also a free muscular flap transfer before grafting. All patients achieved complete healing and started physical therapy before discharging.
   Conclusion: NPWT has proven to be an easy to use, safe and effective therapeutic tool for pediatric patients, with considerable improvement for healing in case of traumatic injuries of foot and ankle, presenting extensive skin and soft tissue defects and bone exposure in children. NPWT is also suitable for children since its use implies less frequent dressing changes, and decreases the level of pain and anxiety, and spares donor areas needed for more complicated procedures and, by creating an optimal grafting bed, it ensures good outcomes, in the short term and long term as well. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Enescu, Dan Mircea; Stoicescu, Simona; Tatar, Raluca] Carol Davila Univ Med & Pharm, Bucharest, Romania.
   [Enescu, Dan Mircea; Stoicescu, Simona; Tomita, Maria; Nacea, Iulia; Ionita, Dan; Tatar, Raluca] Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg & Burns, 30-32 Iancu Hunedoara Blvd,1st Dist, Bucharest 011743, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Stoicescu, S (通讯作者)，Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg & Burns, 30-32 Iancu Hunedoara Blvd,1st Dist, Bucharest 011743, Romania.
EM simona_ioana@hotmail.com
RI NACEA, DOINA IULIA/OLR-9981-2025; Tatar, Raluca/AAF-4712-2021
OI NACEA, DOINA IULIA/0009-0008-9760-5896; Tatar,
   Raluca/0000-0002-4606-4064
FU European Federation of Societies of Microsurgery (EFSM)
FX This paper is part of a Supplement supported by the European Federation
   of Societies of Microsurgery (EFSM).
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NR 24
TC 7
Z9 9
U1 0
U2 9
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD DEC
PY 2020
VL 51
SU 4
SI SI
BP S9
EP S15
DI 10.1016/j.injury.2020.03.027
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA PH6XS
UT WOS:000600553500003
PM 32284186
DA 2026-07-24
ER
PT J
AU Cai, T
   Zhang, L
   Zhu, KP
   Hu, JP
   Zhan, TC
   Liu, LW
   Li, C
   Zhang, CL
AF Cai, Tao
   Zhang, Lei
   Zhu, Kunpeng
   Hu, Jianping
   Zhan, Taichen
   Liu, Liwei
   Li, Cheng
   Zhang, Chunlin
TI Retrospective Clinical Evaluation of Negative-Pressure Wound Therapy for
   Infection Prevention Following Malignant Pelvic Bone Tumor Resection
   Reconstruction
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE clinical research; infection; malignancy; negative-pressure wound
   therapy; pelvic tumor; resection; tumor recurrence; vacuum-sealing
   drainage; wound care
ID SURGERY
AB OBJECTIVE: To evaluate the clinical outcomes of negative-pressure wound therapy (NPWT) for infection prevention following pelvic reconstruction after malignant bone tumor resection.
   METHODS: The study involved 82 patients who underwent pelvic reconstruction following en-bloc resection of malignant bone tumors between January 2003 and January 2016. Forty patients were treated with NPWT via implantation of vacuum-sealing drainage (VSD) materials into the pelvic cavity to prevent infection and wound problems (VSD group), and the remaining 42 patients underwent conventional treatment (control group). Study authors compared the inpatient length of stay, antibiotic use, drainage volume, time to wound closure, and infection rates between groups. Investigators also conducted cell cultures of the wound cavity washing fluid and hematoxylin-eosin staining for VSD materials to find recurrent tumor cells.
   RESULTS: In the VSD group, one patient (2.5%) had a superficial wound problem. In the control group, 18 patients (42.9%) had deep infection or wound problems. The VSD group had a significantly decreased infection rate, duration of antibiotic administration and inpatient stay, as well as increased wound healing compared with the control group (P < .05). Further, no tumor cells were observed in the VSD material or the wound cavity washing fluid.
   CONCLUSIONS: The application of NPWT with VSD material may be an effective and reliable method for preventing infection in patients who undergo pelvic reconstruction following malignant tumor resection.
C1 [Cai, Tao; Zhang, Lei; Zhu, Kunpeng; Hu, Jianping; Zhan, Taichen; Liu, Liwei; Li, Cheng; Zhang, Chunlin] Tongji Univ, Peoples Hosp 10, Sch Med, Shanghai, Peoples R China.
C3 Tongji University
RP Cai, T (通讯作者)，Tongji Univ, Peoples Hosp 10, Sch Med, Shanghai, Peoples R China.
RI Zhang, Lei/A-1412-2014; Hu, Jianping/JFL-0486-2023
FU National Natural Science Foundation of China [81572630, 81872174];
   Shanghai Science and Technology Talents Program [19XD1402900];
   Fundamental Research Funds for the Central Universities [22120180385]
FX The results of this project were previously reported at the 19th
   conference of the International Society of Limb Salvage, Osaka, Japan.
   This project was supported by grants from the National Natural Science
   Foundation of China (no. 81572630, no. 81872174), the Shanghai Science
   and Technology Talents Program (no. 19XD1402900), and Fundamental
   Research Funds for the Central Universities (no. 22120180385). The
   authors have disclosed no other financial relationships related to this
   article. Submitted November 17, 2019; accepted in revised form February
   10, 2020.
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NR 17
TC 8
Z9 8
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2021
VL 34
IS 1
BP 1
EP 6
DI 10.1097/01.ASW.0000723280.71047.73
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA PH9ZI
UT WOS:000600760600001
PM 33323804
DA 2026-07-24
ER
PT J
AU Takagi, S
   Oyama, T
   Jimi, S
   Saparov, A
   Ohjimi, H
AF Takagi, Satoshi
   Oyama, Takuto
   Jimi, Shiro
   Saparov, Arman
   Ohjimi, Hiroyuki
TI A Novel Autologous Micrografts Technology in Combination with Negative
   Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in
   Chronic/Refractory Ulcer
SO HEALTHCARE
LA English
DT Article
DE regenerative medicine; chronic wounds; micrografts
AB Negative pressure wound therapy (NPWT) has been commonly used over the years for a wide range of chronic/refractory lesions. Alternatively, autologous micrografting technology is recently becoming a powerful modality for initiating wound healing. The case presented is of a patient with a lower leg ulcer that had responded poorly to NPWT alone for three weeks. Consequently, the patient was put on a combination therapy of NPWT and micrografting. After injection of a dermal tissue micrografts suspension into the entire wound bed, NPWT was performed successively for two weeks, resulting in fresh granulation tissue formation. Thereafter, the autologous skin graft was taken well. This case study indicates that for a chronic/refractory ulcer patient with poor NPWT outcome, combination therapy using micrografting treatment and NPWT could rapidly initiate and enhance granulation tissue formation, creating a favorable bedding for subsequent skin grafting.
C1 [Takagi, Satoshi; Oyama, Takuto; Ohjimi, Hiroyuki] Fukuoka Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Fukuoka 8140180, Japan.
   [Jimi, Shiro] Fukuoka Univ, Fac Med, Cent Lab Pathol & Morphol, Fukuoka 8140180, Japan.
   [Saparov, Arman] Nazarbayev Univ, Sch Med, Dept Med, Nur Sultan 010000, Kazakhstan.
C3 Fukuoka University; Fukuoka University; Nazarbayev University
RP Takagi, S (通讯作者)，Fukuoka Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Fukuoka 8140180, Japan.
EM stakagi@fukuoka-u.ac.jp; oyt1974@yahoo.co.jp; sjimi@fukuoka-u.ac.jp;
   asaparov@nu.edu.kz; ohjimi@fukuoka-u.ac.jp
OI Saparov, Arman/0000-0002-4407-1236; Takagi, Satoshi/0000-0003-4052-4522
CR Alvarez X, 2017, Int. J. Res. Studies Med. Health Sci, V2, P19
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NR 25
TC 10
Z9 11
U1 0
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD DEC
PY 2020
VL 8
IS 4
AR 513
DI 10.3390/healthcare8040513
PG 6
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA PJ0IR
UT WOS:000601463700001
PM 33255590
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Nuutila, K
   Broomhead, M
   Proppe, K
   Eriksson, E
AF Nuutila, Kristo
   Broomhead, Michael
   Proppe, Karl
   Eriksson, Elof
TI Study Comparing Platform Wound Dressing, a Negative-Pressure Device
   without a Filler, with Three Conventional Negative-Pressure Wound
   Therapy Systems in the Treatment of Excisional and Incisional Wounds
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; GAUZE; CONTRACTION; PARADOX; FOAM
AB Background: All common negatiVe-pressure wound therapy systems include a material, usually foam or gauze, at the wound/ device interface. In this precliniral study, the authors have compared the effects on different wound healing parameters in the three most common negative-pressure wound therapy systems (i.e., V.A.C.VIA, PREVENA, and PICO) with a new device without foam or gauze (i.e., Platform Wound Dressing). A strong effort was made to avoid bias. The study was conducted under good laboratory practice conditions, with the presence of an independent observer.
   Methods: In pigs, three types of wounds were studied: full-thickness excisions, open incisions, and sutured dosed incisions. Several macroscopic and microscopic parameters were studied. The pigs were euthanized on day 9 and all wounds were processed for histology and excisions 101 immunohistochemistry.
   Results: In general, the devices produced similar results, with only a few significant differences. In the excisions, the Platform I'Vound Dressing reduced wound area more than the V.A.C.VIA and the PICO, In the extisional wounds, reepithelialifation was the saute. in open incisions, PREVENA was better than the Platform Wound Dressing. Histologic examination showed that, in open incisions, there was less inflammation in the PREVENA-treated in comparison with the Platform Wound Dressing- and the PICO-treated wounds, butte mohistochemical analyses showed that the Platform Wound Dressing-treated excisions had significantly more blood vessels (von Willebrand factor) than the VA.C.VIA-treated ones and that the PICO caused less T-cell activation (CDS) than the other two.
   Conclusion: The devices-with foam, with gauze, or without either and just an embossed inembrane-performed equally in general.
C1 [Nuutila, Kristo; Broomhead, Michael; Proppe, Karl; Eriksson, Elof] Appl Tissue Technol LLC, Hingham, MA USA.
RP Eriksson, E (通讯作者)，99 Derby St,Suite 200, Hingham, MA 02043 USA.
EM elof@comcast.net
FU U.S. Army Medical Research Acquisition Activity [W81XWH-16-1-0784]
FX All authors are employees of Applied Tissue Technologies, which
   manufactures the Platform Wound Dressings. This material is based upon
   work supported by the U.S. Army Medical Research Acquisition Activity
   under contract no. W81XWH-16-1-0784.
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NR 34
TC 9
Z9 10
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1
BP 76
EP 86
DI 10.1097/PRS.0000000000007450
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA PL4GG
UT WOS:000603081800021
PM 33370053
DA 2026-07-24
ER
PT J
AU Frear, CC
   Zang, T
   Griffin, BR
   McPhail, SM
   Parker, TJ
   Kimble, RM
   Cuttle, L
AF Frear, Cody C.
   Zang, Tuo
   Griffin, Bronwyn R.
   McPhail, Steven M.
   Parker, Tony J.
   Kimble, Roy M.
   Cuttle, Leila
TI The modulation of the burn wound environment by negative pressure wound
   therapy: Insights from the proteome
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID ASSISTED CLOSURE THERAPY; BLISTER FLUID PROTEOME; NORMALIZATION METHODS;
   EXPRESSION; CYTOSCAPE; FILAMIN; SWINE
AB Negative pressure wound therapy has been used to promote wound healing in a variety of settings, including as an adjunct to silver-impregnated dressings in the acute management of paediatric burns. Fluid aspirated by the negative pressure wound therapy system represents a potentially insightful research matrix for understanding the burn wound microenvironment and the intervention's biochemical mechanisms of action. The aim of this study was to characterize the proteome of wound fluid collected using negative pressure wound therapy from children with small-area thermal burns. Samples were obtained as part of a randomized controlled trial investigating the clinical efficacy of adjunctive negative pressure wound therapy. They were compared with blister fluid specimens from paediatric burn patients matched according to demographic and injury characteristics. Protein identification and quantification were performed via liquid chromatography tandem mass spectrometry and sequential window acquisition of all theoretical mass spectra data-independent acquisition. Proteins and biological pathways that were unique to or enriched in negative pressure wound therapy fluid samples were evaluated using principal components, partial least squares-discriminant, and gene ontology enrichment analyses. Eight viable samples of negative pressure wound therapy fluid were collected and analyzed with eight matched blister fluid samples. A total of 502 proteins were quantitatively profiled in the negative pressure wound therapy fluid, of which 444 (88.4%) were shared with blister fluid. Several proteins exhibited significant abundance differences between fluid types, with negative pressure wound therapy fluid showing a higher abundance of matrix metalloproteinase-9, arginase-1, low affinity immunoglobulin gamma Fc region receptor III-A, filamin-A, alpha-2-macroglobulin, and hemoglobin subunit alpha. The results lend support to the hypothesis that negative pressure wound therapy augments wound healing through the modulation of factors involved in the inflammatory response, granulation tissue synthesis, and extracellular matrix maintenance. Data are available via ProteomeXchange with identifier PXD023168.
C1 [Frear, Cody C.; Zang, Tuo; Griffin, Bronwyn R.; Kimble, Roy M.; Cuttle, Leila] Ctr Childrens Burns & Trauma Res, South Brisbane, Qld, Australia.
   [Frear, Cody C.; Kimble, Roy M.] Univ Queensland, Fac Med, Herston, Qld, Australia.
   [Zang, Tuo; Griffin, Bronwyn R.; McPhail, Steven M.; Parker, Tony J.; Cuttle, Leila] Queensland Univ Technol, Fac Hlth, Kelvin Grove, Qld, Australia.
   [McPhail, Steven M.] Metro South Hlth, Clin Informat Directorate, Brisbane, Qld, Australia.
   [Kimble, Roy M.] Queensland Childrens Hosp, South Brisbane, Qld, Australia.
C3 University of Queensland; Queensland University of Technology (QUT);
   Childrens Health Queensland Hospital & Health Service; Queensland
   Childrens Hospital
RP Frear, CC (通讯作者)，Childrens Hlth Res Ctr, Ctr Childrens Burns & Trauma Res, 62 Graham St, South Brisbane, Qld 4101, Australia.
EM cody.frear@uqconnect.edu.au
RI ; Kimble, Roy/B-4160-2011; Cuttle, Leila/U-9376-2017; Griffin,
   Bronwyn/AEB-6299-2022; McPhail, Steven/JMR-2141-2023
OI Frear, Cody/0000-0002-6011-2472; Zang, Tuo/0000-0002-1280-9638; Parker,
   Tony/0000-0002-5118-524X; Cuttle, Leila/0000-0002-2282-4815; Griffin,
   Bronwyn/0000-0002-6182-9125; McPhail, Steven/0000-0002-1463-662X
FU Smith Nephew [150510-0335/53]
FX Smith & Nephew, Grant/Award Number: #150510-0335/53
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NR 40
TC 14
Z9 20
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR
PY 2021
VL 29
IS 2
BP 288
EP 297
DI 10.1111/wrr.12887
EA DEC 2020
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA QR8SI
UT WOS:000603165100001
PM 33374033
DA 2026-07-24
ER
PT J
AU Wilkinson, HN
   Longhorne, FL
   Roberts, ER
   Brownhill, VR
   Hardman, MJ
AF Wilkinson, Holly N.
   Longhorne, Francesca L.
   Roberts, Elizabeth R.
   Brownhill, Varuni R.
   Hardman, Matthew J.
TI Cellular benefits of single-use negative pressure wound therapy
   demonstrated in a novel ex vivo human skin wound model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FOAM
AB Negative pressure wound therapy is a widely used treatment for chronic, nonhealing wounds. Surprisingly, few studies have systematically evaluated the cellular and molecular effects of negative pressure treatment on human skin. In addition, no study to date has directly compared recently available single-use negative pressure modalities to traditional negative pressure devices in a controlled setting. Here we developed a novel large-scale ex vivo human skin culture system to effectively evaluate the efficacy of two different negative pressure wound therapy modalities. Single-use and traditional negative pressure devices were applied to human ex vivo wounded skin sheets cultured over a period of 48 hours. Cellular tissue response to therapy was evaluated via a combination of histological analysis and transcriptional profiling, in samples collected from the wound edge, skin adjacent to the wound, and an extended skin region. Single-use negative pressure wound therapy caused less damage to wound edge tissue than traditional application, demonstrated by improved skin barrier, reduced dermal-epidermal junction disruption and a dampened damage response. Transcriptional profiling confirmed significantly less activation of multiple pro-inflammatory markers in wound edge skin treated with single-use vs traditional negative pressure therapy. These findings may help to explain the greater efficacy of sNPWT in the clinic, while offering a noninvasive system to develop improved NPWT-based therapies.
C1 [Wilkinson, Holly N.; Longhorne, Francesca L.; Roberts, Elizabeth R.; Hardman, Matthew J.] Univ Hull, Ctr Atherothrombosis & Metab Dis, Hull York Med Sch, Kingston Upon Hull, N Humberside, England.
   [Brownhill, Varuni R.] TJ Smith & Nephew Ltd, Kingston Upon Hull, N Humberside, England.
C3 University of York - UK; University of Hull
RP Hardman, MJ (通讯作者)，Univ Hull, Castle Hill Hosp, Daisy Bldg,2nd Floor, Kingston Upon Hull HU16 5JQ, N Humberside, England.
EM m.hardman@hull.ac.uk
RI ; Hardman, Matthew/ABE-4936-2020
OI Wilkinson, Holly/0000-0002-8453-7264; Hardman,
   Matthew/0000-0002-6423-5074
FU TJ Smith and Nephew Ltd
FX TJ Smith and Nephew Ltd
CR [Anonymous], 2009, R: A Language and Environment for Statistical Computing
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NR 42
TC 13
Z9 14
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR
PY 2021
VL 29
IS 2
BP 298
EP 305
DI 10.1111/wrr.12888
EA DEC 2020
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA QR8SI
UT WOS:000603470900001
PM 33378127
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Nishii, K
   Nakajima, T
   Yamamoto, T
   Tanaka, K
   Sakairi, Y
   Wada, H
   Suzuki, H
   Yoshino, I
AF Nishii, Kai
   Nakajima, Takahiro
   Yamamoto, Takayoshi
   Tanaka, Kazuhisa
   Sakairi, Yuichi
   Wada, Hironobu
   Suzuki, Hidemi
   Yoshino, Ichiro
TI Management of thoracic empyema with broncho-pulmonary fistula in
   combination with negative-pressure wound therapy
SO GENERAL THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; NPWT; Thoracic empyema; Open-window
   thoracostomy
ID VACUUM-ASSISTED CLOSURE
AB Objective Intrathoracic negative-pressure wound therapy (NPWT) has been introduced as a novel therapeutic device for the management of empyema. NPWT is expected to reduce the empyema cavity more rapidly than standard treatments; however, no objective analysis of the function of NPWT has yet been conducted. The study objective was to evaluate the efficacy of NPWT in the management of thoracic empyema. Methods Ten patients with stage II or III thoracic empyema treated with NPWT were retrospectively analyzed. The volume of the empyema cavity was measured, and the volume change after the administration of NPWT was calculated. A comparison with the institutional historical controls was also performed. Results The patients had initially undergone fenestration of the chest wall for empyema, and eight had bronchopleural fistula and required procedures to close the fistula. The mean duration of NPWT was 71.1 days (4-190 days). The mean volume of the empyema cavity decreased from 230.2 ml (42.8-788.4 ml) to 78.5 ml (5.2-185.3 ml) by applying NPWT (P = 0.02), and the mean % decrease was 58.7% (0-87.9%). Ultimately, the empyema cavity was able to be cleaned in nine, including seven who were cured by subsequent thoracoplasty and two who were cured without thoracoplasty. The current study group had a tendency toward an early cure with less chest wall destruction, a less hospital stay after open window thoracotomy compared to historical control. Conclusions NPWT enables the effective volume reduction and cleaning of the empyema cavity and achieves an early cure and reduced destruction of the chest wall.
C1 [Nishii, Kai; Nakajima, Takahiro; Yamamoto, Takayoshi; Tanaka, Kazuhisa; Sakairi, Yuichi; Wada, Hironobu; Suzuki, Hidemi; Yoshino, Ichiro] Chiba Univ, Grad Sch Med, Dept Gen Thorac Surg, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2608670, Japan.
C3 Chiba University
RP Nakajima, T (通讯作者)，Chiba Univ, Grad Sch Med, Dept Gen Thorac Surg, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2608670, Japan.
EM takahiro_nakajima@med.miyazaki-u.ac.jp
RI Ichiro, Yoshino/HCH-1137-2022; Suzuki, Hidemi/GVS-5642-2022; Nakajima,
   Takahiro/GRX-7909-2022
OI Suzuki, Hidemi/0000-0002-8983-433X; Nakajima,
   Takahiro/0000-0002-4937-5378
CR Aru GM, 2010, ANN THORAC SURG, V90, P266, DOI 10.1016/j.athoracsur.2010.04.092
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NR 10
TC 13
Z9 15
U1 0
U2 4
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1863-6705
EI 1863-6713
J9 GEN THORAC CARDIOVAS
JI Gen. Thorac. Cardiovasc. Surg.
PD MAY
PY 2021
VL 69
IS 5
BP 843
EP 849
DI 10.1007/s11748-020-01554-5
EA JAN 2021
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA RP7LS
UT WOS:000604155500001
PM 33389593
DA 2026-07-24
ER
PT J
AU Hernigou, P
   Hernigou, J
   Scarlat, M
AF Hernigou, Philippe
   Hernigou, Jacques
   Scarlat, Marius
TI The Dark Age of medieval surgery in France in the first part of Middle
   Age (500-1000): royal touch, wound suckers, bizarre medieval surgery,
   monk surgeons, Saint Healers, but foundation of the oldest worldwide
   still-operating hospital
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
DE Middle Ages surgery; Wound suckers; Debridement in Middle Ages; Medieval
   negative pressure wound therapy; Bizarre medieval surgery; Cautery;
   Blood-letting; Leech therapy; Maggot therapy; Trepanning; Monk surgeons;
   Saint Healers; Royal touch; &#8220; Hotel Dieu&#8221; hospital; Clovis;
   Charlemagne
ID HISTORY; LEG
AB Purpose During the Middle Ages, the Christian church established itself as the dominant force over all aspects of medieval life, including the practice of medicine. As the Church's influence expanded across Europe, the role of lay practitioners in medicine declined, and clerics gradually assumed the role of healers in surgical practice as the cure of the soul was felt to take precedence over cure of bodily ills. Material and methods A retrospective analysis of hospital foundation, old-school surgical techniques still used today was performed during the first part of the Middle Age. Results The Hospital Hotel Dieu in Paris was founded and remains the oldest worldwide still-operating hospital. The monastery became a resting place for travelers, as well as a place of refuge for the sick. As this role expanded, monks often developed considerable surgical expertise. This led to fierce competition for saintly relics and pilgrims. Among the myriad of saints to whom powers of healing were ascribed, the names of Damian and Cosmas figure prominently in medical history. Old-school medieval surgery was also performed with some bizarre techniques such as lip service by wound suckers, cautery, blood-letting, leech therapy, and maggot therapy. Conclusion This account of surgery before it became scientific is based on a chronology that runs from the Clovis baptism to the reign of Charlemagne; much of the medicine in this period was based on ancient doctrines; indeed, much of the development of medicine in the period called as "Dark Age" was due to the slow and difficult business of recovering and trying to understand ancient medicine
C1 [Hernigou, Philippe] Univ Paris East, Orthoped Dept, Henri Mondor Hosp, Paris, France.
   [Hernigou, Jacques] EpiCURA Hosp, Dept Orthopaed & Traumatol Surg, Baudour Hornu, St Ghislain, Belgium.
   [Scarlat, Marius] Grp ELSAN, Clin Chirurg St Michel, Dept Chirurg Orthoped, Av Orient, F-83100 Toulon, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP
RP Hernigou, P (通讯作者)，Univ Paris East, Orthoped Dept, Henri Mondor Hosp, Paris, France.
EM philippe.hernigou@wanadoo.fr
RI Hernigou, Jacques/AAO-6778-2020
OI Hernigou, Jacques/0000-0001-9402-6401
CR Coppee H, 2002, HIST CONQUEST SPAIN, VII
   Dirk JH, 2008, NEGATIVE PRESSURE WO, P17
   Fornaciari A, 2018, LANCET, V392, P1111, DOI 10.1016/S0140-6736(18)31815-4
   Gonzalez Justo., 1984, The Early Church to the Dawn of the Reformation, SC 1
   Harris Thomas, 1838, Med Exam (Phila), V1, P250
   HEN Y, 1993, REV BELGE PHILOL HIS, V71, P271, DOI 10.3406/rbph.1993.3880
   Hernigou P, 2020, INT ORTHOP, V44, P795, DOI 10.1007/s00264-020-04506-z
   Hernigou P, 2015, INT ORTHOP, V39, P2081, DOI 10.1007/s00264-015-2868-6
   Hernigou P, 2014, INT ORTHOP, V38, P2631, DOI 10.1007/s00264-014-2511-y
   Hernigou P, 2014, INT ORTHOP, V38, P1535, DOI 10.1007/s00264-014-2278-1
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   Hussey EdwardLaw., 1853, The Archaeological Journal, V10, P187, DOI 10.1080/00665983.1853.10850902
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NR 21
TC 14
Z9 19
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD JUN
PY 2021
VL 45
IS 6
BP 1633
EP 1644
DI 10.1007/s00264-020-04914-1
EA JAN 2021
PG 12
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA SN4BQ
UT WOS:000604803500005
PM 33394075
DA 2026-07-24
ER
PT J
AU Gao, X
   Fan, HY
   Huang, R
   Sui, YQ
   Li, F
   Yin, HL
AF Gao, Xu
   Fan, Hai-yu
   Huang, Rui
   Sui, Yong-qiang
   Li, Fei
   Yin, Hai-lei
TI Management of Open Calcaneal Fractures with Medial Wounds by One-Stage
   Sequential Reduction and Frame Structure Fixation Using Percutaneous
   Kirschner Wires
SO ORTHOPAEDIC SURGERY
LA English
DT Article
DE Calcaneal fractures; Kirschner wires; Open injury; Percutaneous fixation
ID INTRAARTICULAR FRACTURES; COMPLICATIONS
AB Objective To assess the clinical outcomes of open calcaneal fractures with medial wounds treated with one-stage management, including early modern wound care, sequential reduction, and frame structure fixation using percutaneous Kirschner wires.
   Methods A total of 19 patients with open calcaneal fractures admitted to our hospital from May 2016 to March 2019 were selected in this study. Twelve type-II and seven type-IIIA medial open injuries were identified according to the classification of Gustilo and Anderson. Fractures were stratified by Sanders classification, including nine type-II fractures, seven type-III fractures, and three type-IV fractures. All patients accepted one-stage irrigation and debridement, sequential reduction of calcaneal fractures through the open medial wound, percutaneous Kirschner wire fixation, and primary closure of wounds covered with vacuum-assisted closure (VAC) device. The Bohler angle, the Gissane angle, and the width of the calcaneus were compared before and after surgery. The functional results were evaluated according to the Paley and Hall score system, visual analogue scale (VAS), American Orthopaedic Foot and Ankle Society (AOFAS) ankle and hindfoot score, Maryland Foot Score, and related complications.
   Results The follow-up duration for all patients ranged from 14 to 28 months (mean, 22.7 months). The angle of Bohler and Giasane was increased from (-7.6 degrees +/- 15.0 degrees) and (96.6 degrees +/- 7.6 degrees) before surgery to (23.7 degrees +/- 6.1 degrees) and (124.1 degrees +/- 7.1 degrees) postoperatively (P < 0.05), respectively. Three cases of superficial infection and two cases of wound dehiscence were observed in our study, which were then successfully treated with wound debridement, VAC replacement, appropriate use of antibiotics, and delayed closure. The last follow-up revealed three cases of lateral wall expansion and six cases of mild-to-moderate subtalar arthritis based on the Paley and Hall scoring system. According to the AOFAS ankle and hindfoot score, one case showed excellent results, 14 cases exhibited good results, and four cases displayed fair results, with the mean of 80.7 +/- 6.7 points (range, 70-90). The Maryland Foot Score revealed one case of excellent outcomes, nine cases of good outcomes, and nine cases of fair outcomes with an average of 76.8 +/- 8.6 points (range, 62-90). The mean VAS for pain was 1.8 +/- 1.5 (range, 0-5), and a total of 14 patients complained of mild-to-moderate pain when walking for a more extended period. Severe complications, such as deep infection, osteomyelitis, and soft tissue necrosis, were not observed during follow-up.
   Conclusions Collectively, one-stage management allowed the direct restoration of calcaneal morphology with a minimal invasion of soft tissues in most open calcaneal fractures with medial wounds, and the functional outcomes were comparable to previous data.
C1 [Gao, Xu] Qingdao Univ, Dept Orthopaed Surg, Qingdao, Peoples R China.
   [Fan, Hai-yu] 971 Hosp Peoples Liberat Army PLA, Dept Burn & Plast Surg, Qingdao, Peoples R China.
   [Huang, Rui; Li, Fei; Yin, Hai-lei] 971 Hosp Peoples Liberat Army PLA, Orthopaed Surg 2, Qingdao, Peoples R China.
   [Sui, Yong-qiang] Luoyang Ship Mat Res Inst, Dept State Key Lab Marine Corros & Protect, Qingdao, Peoples R China.
C3 Qingdao University
RP Yin, HL (通讯作者)，971 Hosp Peoples Liberat Army PLA, Dept Orthopaed Surg 2, 22 Min Jiang Rd, Qingdao 266071, Peoples R China.
EM 1431951086@qq.com
RI ; yin, hailei/LGZ-3641-2024
OI Gao, X/0000-0002-5065-1077; 
CR Abdelgaid Sherif Mohamed, 2012, Foot Ankle Surg, V18, P164, DOI 10.1016/j.fas.2011.07.005
   Aldridge JM, 2004, J ORTHOP TRAUMA, V18, P7, DOI 10.1097/00005131-200401000-00002
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NR 33
TC 4
Z9 10
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1757-7853
EI 1757-7861
J9 ORTHOP SURG
JI Orthop. Surg.
PD FEB
PY 2021
VL 13
IS 1
BP 225
EP 236
DI 10.1111/os.12902
EA JAN 2021
PG 12
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA QC1ZF
UT WOS:000604862900001
PM 33403804
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hirai, Y
   Yamashita, Y
   Tazawa, H
   Suzuki, T
   Fujimoto, S
   Uemura, T
   Mimura, T
AF Hirai, Yuya
   Yamashita, Yoshinori
   Tazawa, Hirofumi
   Suzuki, Takahisa
   Fujimoto, Sari
   Uemura, Takahiro
   Mimura, Takeshi
TI Negative pressure wound therapy for broncho-pleural fistula with
   collapsed lung
SO GENERAL THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE Empyema; Broncho-pleural fistula; Negative pressure wound therapy
ID MANAGEMENT
AB We present a case of the broncho-pleural fistula with a collapsed lung that was developed 2 weeks after right lower lobectomy. The patient urgently underwent open-window thoracostomy. However, the residual lung remained collapsed. To expand the lung and close the broncho-pleural fistula, negative pressure wound therapy was initiated 20 days after the procedure. The lung expanded within a few days, and the residual thoracic cavity gradually contracted. Subsequently, 2.5 months later, the remaining thoracic cavity was successfully closed using omentoplasty. No recurrence of the broncho-pleural fistula was observed for 1 year. If the lung could be inflated to reduce dead space in the thoracic cavity, broncho-pleural fistula with collapsed lung may be treated with bronchial stump coverage and negative pressure wound therapy.
C1 [Hirai, Yuya; Yamashita, Yoshinori; Mimura, Takeshi] Natl Hosp Org Kure Med Ctr & Chugoku Canc Ctr, Dept Gen Thorac Surg, 3-1 Aoyama Cho, Hiroshima 7370023, Japan.
   [Tazawa, Hirofumi; Suzuki, Takahisa] Natl Hosp Org Kure Med Ctr & Chugoku Canc Ctr, Dept Surg, 3-1 Aoyama Cho, Hiroshima 7370023, Japan.
   [Fujimoto, Sari; Uemura, Takahiro] Natl Hosp Org Kure Med Ctr & Chugoku Canc Ctr, Dept Plast Surg, 3-1 Aoyama Cho, Hiroshima 7370023, Japan.
RP Mimura, T (通讯作者)，Natl Hosp Org Kure Med Ctr & Chugoku Canc Ctr, Dept Gen Thorac Surg, 3-1 Aoyama Cho, Hiroshima 7370023, Japan.
EM t.mimura88@gmail.com
OI Mimura, Takeshi/0000-0002-2809-4833
CR Aru GM, 2010, ANN THORAC SURG, V90, P266, DOI 10.1016/j.athoracsur.2010.04.092
   ASAMURA H, 1992, J THORAC CARDIOV SUR, V104, P1456
   Boulton BJ, 2010, OPERATIVE TECHNIQUES, V15, P53, DOI DOI 10.1053/j.optechstcvs.2010.02.003
   Regnard JF, 2000, J THORAC CARDIOV SUR, V120, P270, DOI 10.1067/mtc.2000.106837
   Shen KR, 2017, J THORAC CARDIOV SUR, V153, pE129, DOI 10.1016/j.jtcvs.2017.01.030
NR 5
TC 0
Z9 1
U1 0
U2 2
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1863-6705
EI 1863-6713
J9 GEN THORAC CARDIOVAS
JI Gen. Thorac. Cardiovasc. Surg.
PD MAY
PY 2021
VL 69
IS 5
BP 890
EP 893
DI 10.1007/s11748-020-01569-y
EA JAN 2021
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA RP7LS
UT WOS:000605139500005
PM 33400203
DA 2026-07-24
ER
PT J
AU Isaac, DL
AF Isaac, Dona Lyndhia
TI Complex Wound Management Using Negative Pressure Wound Therapy With
   Instillation and Dwell Time in a Cancer Care Setting
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article; Proceedings Paper
CT Spring Symposium on Advanced Wound Care (SAWC)
CY MAY 07-11, 2019
CL San Antonio, TX
DE negative pressure wound therapy with instillation and dwell time;
   cancer; cancer-related wounds; complex wound; NPWTi-d
ID VACUUM-ASSISTED CLOSURE; INGUINAL LYMPHADENECTOMY; PENILE CANCER;
   COMPLICATIONS; ULCERS
AB Introduction. Unresolved wound healing represents a major health care cost with a negative impact on patient quality of life, especially among oncology patients who exhibit a delay in the wound healing cascade due to chemotherapy and radiation. In order to address this problem, the author utilized negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) to cleanse wounds of debris and help promote healing. Objective. The author examines the impact of NPWTi-d on multiple indicators of wound healing progress in 6 cancer patients with complex wounds and multiple comorbidities. Materials and Methods. The NPWTi-d was initiated with instillation of normal saline or 0.125% hypochlorite solution, which was allowed to dwell for 3 to 20 minutes, followed by 2 to 3.5 hours of -125 mm Hg continuous negative pressure. Dressing changes were performed every 2 to 3 days. Debridements, incision and drainage, and antibiotics were administered as necessary. Results. A total of 1 woman and 5 men (average age, 62 years; range, 53-78 years) presented with the following wounds: surgical dehiscence (n = 3), pressure injury (n = 1), chronic seroma (n = 1), and abdominal wall abscess (n = 1). Malignancy was not detectable in any wounds. Patient comorbidities included diabetes, hypertension, and past treatment for cancers. The NPWTi-d was applied for 1 to 2 weeks, after which the wounds exhibited a reduction in slough, an improvement in granulation tissue, and a decrease in wound volume. Wounds were closed with a flap or transitioned to conventional NPWT prior to discharge home or to a rehabilitation facility for outpatient recovery. Conclusions. As shown in this case series, NPWTi-d was a beneficial tool for cleansing the wound bed, thus creating a moist, closed wound environment conducive to healing. Using NPWTi-d supported the formation of a healthy wound bed and contributed to rapid, positive outcomes in this patient population.
C1 [Isaac, Dona Lyndhia] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center
RP Isaac, DL (通讯作者)，Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
EM isaacd@mskcc.org
FU NCI NIH HHS [P30 CA008748] Funding Source: Medline
CR Althumairi AA, 2016, WORLD J SURG, V40, P1755, DOI 10.1007/s00268-016-3450-0
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NR 19
TC 4
Z9 4
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2020
VL 32
IS 5
BP 118
EP 122
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Dermatology; Surgery
GA PQ8GI
UT WOS:000606781600001
PM 32804665
DA 2026-07-24
ER
PT J
AU Zhu, BZ
   Cao, DS
   Xie, J
   Li, HH
   Chen, ZH
   Bao, Q
AF Zhu, BangZhong
   Cao, DongSheng
   Xie, Juan
   Li, HongHong
   Chen, ZengHong
   Bao, Qiong
TI Clinical experience of the use of Integra in combination with negative
   pressure wound therapy: an alternative method for the management of
   wounds with exposed bone or tendon
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Integra; take rate; time; negative pressure wound therapy
AB The use of Integra has attracted great interest in the treatment of wounds with exposed bone or tendon, which may lead to associated morbidities. However, the use of Integra alone results in poor wound outcomes. We conducted a randomized clinical study to evaluate the combined effects of Integra and negative pressure wound therapy (NPWT). Thirty-six patients with wounds with exposed bone or tendons were treated with Integra alone and with a combination of Integra and NPWT (n = 18 respectively). Negative pressure (125 mm Hg) was applied intermittently till Integra was revascularized. The take rate of Integra and time taken from Integra coverage to skin transplantation was recorded for each case. The average take rate of Integra in the conventional treatment group (Integra with partial packing compression dressings) was lower than that for the new treatment group (Integra with NPWT) (p < 0.001, 95% CI: 6.44-0.20). The mean time period from Integra coverage to skin transplantation was longer for the conventional treatment group than for the new treatment group (p < 0.001, 95% CI: -13.18 to -11.24). The application of NPWT could potentially increase the take rate of Integra and shorten the duration of hospital stay. The use of Integra with NPWT could be a treatment option for wounds with exposed bone or tendon.
C1 [Zhu, BangZhong; Cao, DongSheng; Xie, Juan; Li, HongHong; Chen, ZengHong; Bao, Qiong] AnHui Med Univ, Affiliated Hosp 2, Dept Plast & Reconstruct Surg, 678 FuRong Rd, Hefei 230601, Peoples R China.
C3 Anhui Medical University
RP Cao, DS (通讯作者)，AnHui Med Univ, Affiliated Hosp 2, Dept Plast & Reconstruct Surg, 678 FuRong Rd, Hefei 230601, Peoples R China.
EM cds1966@sina.com
CR Apelqvist J, 2000, DIABETES-METAB RES, V16, pS75, DOI 10.1002/1520-7560(200009/10)16:1+<::AID-DMRR139>3.3.CO;2-#
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NR 22
TC 17
Z9 18
U1 0
U2 10
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD FEB 1
PY 2021
VL 55
IS 1
BP 1
EP 5
DI 10.1080/2000656X.2020.1781140
EA DEC 2020
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA QB0BR
UT WOS:000607236400001
PM 33433246
OA gold
DA 2026-07-24
ER
PT J
AU Deniz, H
   Arslanoglu, Y
   Ari, M
AF Deniz, Hayati
   Arslanoglu, Yavuz
   Ari, Murat
TI Better outcomes with a new type of pressure wound therapy for
   mediastinitis after cardiac surgery
SO PROGRESS IN NUTRITION
LA English
DT Article
DE Mediastinit; VAC therapy; Wound
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE MEDIASTINITIS; MANAGEMENT
AB Background: The aim of the present study is to compare the clinical outcomes and survival in our 40 patients underwent NPWT with or without instillation treatment for mediastinitis after cardiac surgery. Materials end Methods: In this study, we retrospectively compared the clinical outcome and survival in 40 patients undergoing VAC therapy with or without instillation treatment for DSWI after cardiac surgery. Only patients with mediastinitis those are consisting of sternum and presternal tissue infection after coronary bypass surgery were included in the present study. Results: Mean age of patients was 58.86 +/- 11.6 and 57 patients of them were female and 33 of them were male. Primary surgery among the 40 patients presenting with DSWI; was coronary artery bypass revascularization. Conclusion: The use of VAC therapy with instillation has changed the management of complicated infected or colonized wounds and has become the standard of care our facility.
C1 [Deniz, Hayati; Arslanoglu, Yavuz; Ari, Murat] Gaziantep Ersin Arslan Educ & Res Hosp, Dept Cardiovasc Surg, Gaziantep, Turkey.
RP Deniz, H (通讯作者)，Fatih Mah 22 Nolu Sok Cankaya Sitesi C Blok Daire, Gaziantep, Turkey.
EM hayatideniz@gmail.com
RI ARSLANOGLU, YAVUZ/JLK-8285-2023; ARI, Murat/MIU-3719-2025
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Catarino PA, 2000, ANN THORAC SURG, V70, P1891, DOI 10.1016/S0003-4975(00)02173-1
   De Feo M, 2001, ANN THORAC SURG, V71, P324, DOI 10.1016/S0003-4975(00)02137-8
   Douville EC, 2004, ANN THORAC SURG, V78, P1659, DOI 10.1016/j.athoracsur.2004.04.082
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NR 12
TC 0
Z9 0
U1 1
U2 2
PU MATTIOLI 1885
PI FIDENZA
PA VIA DELLA LODESANA 649-SX, FIDENZA, 43046 PR, ITALY
SN 1129-8723
J9 PROG NUTR
JI Prog. Nutr.
PD DEC
PY 2020
VL 22
IS 4
AR e2020090
DI 10.23751/pn.v22i4.10930
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PR5NF
UT WOS:000607282500015
DA 2026-07-24
ER
PT J
AU Bas, A
   Aslan, L
   Eralp, IL
AF Bas, Ali
   Aslan, Lercan
   Eralp, Ibrahim Levent
TI Undifferentiated pleomorphic sarcoma of skin in unusual locations:
   Report of two cases
SO JOINT DISEASES AND RELATED SURGERY
LA English
DT Article
DE Dermatologic oncology; ultraviolet exposure; undifferentiated
   pleomorphic sarcoma
ID SOFT-TISSUE
AB Undifferentiated pleomorphic sarcoma (UPS) of the skin is a rare soft tissue sarcoma subtype with a high risk of metastasis and local recurrence. Ultraviolet exposure plays a prominent role in its etiology. Herein, we present two rare cases of UPS of the skin with an occurrence in non-ultraviolet exposed locations and discuss the need of wide resection and the identification of the depth of the tumor. Due to the resection of the skin, resulting defect was undertaken with skin grafting. One case was extending to the fascia and, after the resection, vacuum-assisted closure therapy was used for the formation of granulation tissue. No recurrence was seen after three and four years for either cases. In conclusion, UPS is a rare, aggressive malignant tumor with a high local recurrence and metastasis rate. Suspicion of malignancy in a plaque-like or nodular lesion in the skin is crucial, and local recurrence and metastasis risk is significantly correlated to the success of wide excision.
C1 [Bas, Ali; Aslan, Lercan] Koc Univ Hosp, Dept Orthoped & Traumatol, Istanbul, Turkey.
   [Eralp, Ibrahim Levent] Istanbul Univ, Dept Orthoped & Traumatol, Istanbul, Turkey.
C3 Koc University; Istanbul University
RP Aslan, L (通讯作者)，Koc Univ Hastanesi, Ortopedi & Travmatol Bolumu, TR-34010 Istanbul, Turkey.
EM lercan.aslan86@gmail.com
RI Bas, Ali/AAX-3771-2021; Aslan, Lercan/HLQ-0419-2023
OI Bas, Ali/0000-0001-8339-7418; Aslan, Lercan/0000-0003-1358-3236
CR Atik OS, 2019, EKLEM HAST CERRAHISI, V30, P69, DOI 10.5606/ehc.2019.003
   Brennan MF, 2014, ANN SURG, V260, P416, DOI 10.1097/SLA.0000000000000869
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   Hung GY, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001696
   Kamat NV, 2019, AM J CLIN ONCOL-CANC, V42, P166, DOI 10.1097/COC.0000000000000496
   Kohlmeyer J, 2017, J DTSCH DERMATOL GES, V15, P630, DOI 10.1111/ddg.13249
   Soleymani T, 2017, CURR TREAT OPTION ON, V18, DOI 10.1007/s11864-017-0489-6
   Tardío JC, 2016, J CUTAN PATHOL, V43, P101, DOI 10.1111/cup.12603
   White LM, 2005, INT J RADIAT ONCOL, V61, P1439, DOI 10.1016/j.ijrobp.2004.08.036
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   Ziemer M, 2012, J DTSCH DERMATOL GES, V10, P537, DOI 10.1111/j.1610-0387.2012.07980.x
NR 11
TC 2
Z9 3
U1 0
U2 4
PU TURKISH JOINT DISEASES FOUNDATION
PI CANKARA
PA MUSTAFA KEMAL MAHALLESI, DUMLUPINAR BULVARI 274-2 C2 BLOK OFIS, 5,
   CANKARA, ANKARA, TURKEY
SN 2687-4784
EI 2687-4792
J9 JOINT DIS RELAT SURG
JI Joint Dis. Relat. Surg.
PY 2021
VL 32
IS 1
BP 253
EP 257
DI 10.5606/ehc.2021.78856
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA PT2HR
UT WOS:000608440400038
PM 33463447
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hyldig, N
   Möller, S
   Joergensen, JS
   Bille, C
AF Hyldig, Nana
   Moller, Soren
   Joergensen, Jan Stener
   Bille, Camilla
TI Clinical Evaluation of Scar Quality Following the Use of Prophylactic
   Negative Pressure Wound Therapy in Obese Women Undergoing Cesarean
   Delivery A Trial-Based Scar Evaluation
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE cesarean delivery; incisional negative-pressure wound therapy; scar
   evaluation
AB Objective: To evaluate the cosmetic result of using incisional negative-pressure wound therapy (iNPWT) compared with standard postsurgical dressings in obese women undergoing cesarean delivery (CD).
   Methods: Postcesarean scars were objectively evaluated 6 and 12 months postsurgery by a plastic surgeon using the Manchester Scar Scale and the Stony Brook Scar Evaluation Scale. Subjective scar evaluation and health-related quality of life were assessed using the Patient Scar Assessment Scale and the EQ-5D-5L instrument, respectively. Main outcome measures were the cosmetic and functional outcome of treating a standardized surgical wound with iNPWT compared with standard dressings, changes in scar rating over time, and testing different scar scales for cosmetic evaluation.
   Results: The study found no difference in long-term cosmetic outcomes between iNPWTand standard dressings. The study demonstrated a statistically significant positive change in scar rating from surgery to 12 months postsurgery. A strong association was found between the scar scales with a high correlation between the objective scar scales (R approximately 0.80) and a moderate correlation between the subjective scale and each objective scale (R approximately 0.50).
   Conclusions: Prophylactic iNPWT has been found to reduce the risk of surgical site infection following CD. Conversely, this study was not able to detect a difference in the long-term cosmetic result after CD when compared with standard dressings.
C1 [Hyldig, Nana; Bille, Camilla] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Plast Surg, Odense, Denmark.
   [Hyldig, Nana; Moller, Soren] Univ Southern Denmark, OPEN Open Patient Data Explorat Network, Odense Univ Hosp, Odense, Denmark.
   [Joergensen, Jan Stener] Univ Southern Denmark, Dept Obstet & Gynaecol, Odense Univ Hosp, Inst Clin Res, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Odense University Hospital
RP Hyldig, N (通讯作者)，Odense Univ Hosp, JB Winslowsvej 9A,3th Floor, DK-5000 Odense C, Denmark.
EM nana.hyldig@rsyd.dk; Soren.Moller@rsyd.dk;
   Jan.Stener.Joergensen@rsyd.dk; camilla.bille@rsyd.dk
RI Hyldig, Nana/AAH-5220-2020; Möller, Sören/X-8738-2019
OI Hyldig, Nana/0000-0001-6758-6294; jørgensen, jan
   stener/0000-0001-5222-2535; Möller, Sören/0000-0003-0858-4269
FU iNPWT devicemanufacturer Smith Nephew
FX The substudy was funded by an unrestricted grant from the iNPWT
   devicemanufacturer Smith & Nephew. The company had no influence on study
   design, data collection, data analyses, interpretation of results, or in
   the writing of the report. Two of the authors have received funding or
   honoraria from the company Smith & Nephew (N.H., C.B.). The other
   authors have nothing to disclose.
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   Wu C., 2018, BJOG-INT J OBSTET GY, V3
NR 29
TC 4
Z9 6
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2020
VL 85
IS 6
BP E59
EP E65
DI 10.1097/SAP.0000000000002468
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA PT6FJ
UT WOS:000608708900009
PM 32657852
OA hybrid
DA 2026-07-24
ER
PT J
AU Ryu, JY
   Lee, JH
   Kim, JS
   Lee, JS
   Lee, JW
   Choi, KY
   Chung, HY
   Cho, BC
   Yang, JD
AF Ryu, Jeong Yeop
   Lee, Jung Ho
   Kim, Jong Seong
   Lee, Joon Seok
   Lee, Jeong Woo
   Choi, Kang Young
   Chung, Ho Yun
   Cho, Byung Chae
   Yang, Jung Dug
TI Usefulness of Incisional Negative Pressure Wound Therapy for Decreasing
   Wound Complication Rates and Seroma Formation Following Prepectoral
   Breast Reconstruction
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Mammaplasty; Breast implants
AB Background Seroma is a common complication in prepectoral breast reconstruction. PICOTM dressing, a type of incisional negative pressure wound therapy (iNPWT), was used to reduce complications postoperatively.
   Methods This study was a retrospective cohort study that included patients who underwent prepectoral breast reconstruction between February 2017 and July 2019. There were two groups: one that received PICOTM dressing and a control group. The frequencies of overall complications, major seromas, and reoperations were analyzed. The durations and total amounts of seromas were also analyzed.
   Result Sixty patients were included in this study (PICOTM : 37 and non-PICOTM patients: 23). The overall incidence of complications, major seromas, and frequency of reoperations were lower in the PICO group compared to the non-PICOTM group (18.9% vs. 52.2%, p = 0.007; 16.2% vs. 43.5%, p = 0.020; 2.7% vs. 26.1%, p = 0.006, respectively). Univariate analysis was used to analyze the risk factors for complications due to the application of PICOTM dressing and showed statistically significant results for any complication. When univariate analysis was performed on risk factors for seroma, the duration of seroma showed statistical significance in association with PICOTM dressing status and mastectomy volume. The total number of patients who developed seroma was statistically correlated with age, PICOTM dressing status, and mastectomy volume.
   Conclusions PICOTM dressing after prepectoral breast reconstruction could be a useful tool for reducing the frequency of complications and major seroma, as well as the duration and total incidences of seroma.
C1 [Ryu, Jeong Yeop; Lee, Jung Ho; Kim, Jong Seong; Lee, Joon Seok; Lee, Jeong Woo; Choi, Kang Young; Chung, Ho Yun; Cho, Byung Chae; Yang, Jung Dug] Kyungpook Natl Univ, Dept Plast & Reconstruct Surg, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea.
C3 Kyungpook National University (KNU)
RP Yang, JD (通讯作者)，Kyungpook Natl Univ, Dept Plast & Reconstruct Surg, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea.
EM lambyang@knu.ac.kr
RI ; Ryu, Jeong Yeop/GLQ-9419-2022; Yang, Jung/R-7806-2019
OI Kim, Jong Seong/0000-0002-4725-9277; Lee, Jeong Woo/0000-0003-4903-6066;
   Ryu, Jeong Yeop/0000-0003-2812-5051; 
CR Abbate O, 2020, BREAST CANCER RES TR, V182, P543, DOI 10.1007/s10549-020-05722-2
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NR 18
TC 16
Z9 19
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD APR
PY 2022
VL 46
IS 2
BP 633
EP 641
DI 10.1007/s00266-020-02115-0
EA JAN 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 1C9IU
UT WOS:000609047700002
PM 33474573
DA 2026-07-24
ER
PT J
AU Song, HC
   Xu, Y
   Chang, WC
   Zhuang, JL
   Wu, XW
AF Song, Haichen
   Xu, Yu
   Chang, Wenchuan
   Zhuang, Junli
   Wu, Xiaowei
TI Negative pressure wound therapy promotes wound healing by suppressing
   macrophage inflammation in diabetic ulcers
SO REGENERATIVE MEDICINE
LA English
DT Article
DE autophagy; diabetic ulcer; infiltration; inflammation; macrophage;
   negative pressure wound therapy; wound healing
ID VACUUM-ASSISTED CLOSURE; AUTOPHAGY; CELLS; ANGIOGENESIS; INFECTION;
   INCISIONS; DISEASE; IMPACT; RATS
AB Aim: This work aims to explore the biological role of negative pressure wound therapy (NPWT) in the treatment of diabetic ulcer. Materials & methods: Full-thickness skin defects were created in diabetic (db/db) and non diabetic (db/m) mice to create wound models. The mice were received NPWT or rapamycin injection. Mouse macrophage cells (Raw264.7) were treated with lipopolysaccharide to induce inflammatory response, and then received negative pressure treatment. We observed the wound healing of mice and examined gene and protein expression and CD68(+) macrophage levels. Results: NPWT notably enhanced the wound closure ratio, and inhibited the LC3-II/LC3-I ratio and Beclin-1 expression in diabetes mellitus (DM) mice. NPWT decreased CD68(+) macrophage levels in wound tissues of DM mice. The influence conferred by NPWT was abolished by rapamycin treatment. Negative pressure repressed the LC3-II/LC3-I ratio and the expression of Beclin-1, TNF-alpha, IL-6 and IL-1 beta in the Raw264.7 cells. Conclusion: NPWT promotes wound healing by suppressing autophagy and macrophage inflammation in DM.
C1 [Song, Haichen; Wu, Xiaowei] Wuhan Univ, Renmin Hosp, Dept Plast Surg, Wuhan 430060, Hubei, Peoples R China.
   [Xu, Yu; Chang, Wenchuan] Wuhan Univ, Renmin Hosp, Dept Otolaryngol Head & Neck Surg, Wuhan 430060, Hubei, Peoples R China.
   [Zhuang, Junli] Wuhan Univ, Renmin Hosp, Dept Vasc Surg, Wuhan 430060, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University
RP Xu, Y (通讯作者)，Wuhan Univ, Renmin Hosp, Dept Otolaryngol Head & Neck Surg, Wuhan 430060, Hubei, Peoples R China.
EM xuyu1026@yeah.net
OI Zhuang, Jun-li/0009-0000-6313-7598
CR Agarwal A, 2019, PLAST RECONSTR SURG, V143, p21S, DOI 10.1097/PRS.0000000000005308
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   Wang T, 2019, DIABETES RES CLIN PR, V150, P81, DOI 10.1016/j.diabres.2019.02.024
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NR 36
TC 21
Z9 25
U1 1
U2 36
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1746-0751
EI 1746-076X
J9 REGEN MED
JI Regen. Med.
PD DEC
PY 2020
VL 15
IS 12
BP 2341
EP 2349
DI 10.2217/rme-2020-0050
EA JAN 2021
PG 9
WC Cell & Tissue Engineering; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA QE6AO
UT WOS:000609635600001
PM 33480804
DA 2026-07-24
ER
PT J
AU Sharp, G
   Steffens, D
   Koh, CE
AF Sharp, Gary
   Steffens, Daniel
   Koh, Cherry E.
TI Evidence of negative pressure therapy for anastomotic leak: a systematic
   review
SO ANZ JOURNAL OF SURGERY
LA English
DT Review
DE anastomotic leak; colorectal; endosponge; negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; LONG-TERM EFFICACY; ANTERIOR RESECTION;
   EXPERIENCE; ETVARD
AB Background Anastomotic leak (AL) is a devastating complication. Several new treatment options are available, endoluminal negative pressure therapy is one. The aims of this systematic review are; to report success rates and stoma closure rates following endoluminal negative pressure therapy in colorectal AL patients.
   Methods A systematic review of MEDLINE, PubMed, Cochrane and Embase databases from inception to June 2018. Search limits were; English language, humans, sample >5 and >18 years. Search terms were Endospong* OR Endo-spong* OR Endo spong* OR Endoluminal negative pressure OR Endoluninal vac* OR Vacuum assisted OR negative pressure. Combined with colon OR rectum OR colorect* AND anastomotic leak OR leak*.
   Results Twenty articles met inclusion criteria. There were 334 patients. Reported success rates ranged from 60% to 100%. However, success definition varied considerably. The most widely used definition was endoscopic assessment of residual cavity size, but this also varied from 0.5 cm to 3 cm. Stoma closure rates were only reported in 11 studies and ranged from 31% to 100%. Complication rates were reported in 13 studies (65%). The most common was on-going sepsis.
   Conclusions Included studies suggest that 60-100% of ALs heal with endoluminal negative pressure therapy. However, results from this review need to be interpreted with caution because of the variable definition of success. A more objective assessment of success may be stoma closure but this is only reported in 60% of studies. Further studies are needed to assess the benefit of negative pressure therapy in anastomotic leaks.
C1 [Sharp, Gary; Steffens, Daniel; Koh, Cherry E.] Royal Prince Alfred Hosp, Surg Outcomes Res Ctr SOuRCe, Sydney, NSW, Australia.
   [Steffens, Daniel; Koh, Cherry E.] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.
   [Koh, Cherry E.] Royal Prince Alfred Hosp, Dept Colorectal Surg, Sydney, NSW, Australia.
   [Koh, Cherry E.] Royal Prince Alfred Hosp, RPA Inst Acad Surg, Sydney, NSW, Australia.
C3 University of Sydney; NSW Health; Royal Prince Alfred Hospital;
   University of Sydney; NSW Health; Royal Prince Alfred Hospital;
   University of Sydney; University of Sydney; NSW Health; Royal Prince
   Alfred Hospital
RP Sharp, G (通讯作者)，Royal Prince Alfred Hosp, Surg Outcomes Res Ctr SOuRCe, Missenden Rd, Camperdown, NSW 2050, Australia.
EM garybeau1@yahoo.co.uk
OI Koh, Cherry/0000-0003-2547-0204; Steffens, Daniel/0000-0002-9715-860X
CR [Anonymous], 2009, BMJ-BRIT MED J, V21, P7, DOI [DOI 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, DOI 10.7326/0003-4819-151-4-200908180-00135]
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NR 33
TC 14
Z9 19
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD APR
PY 2021
VL 91
IS 4
BP 537
EP 545
DI 10.1111/ans.16581
EA JAN 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RM0PS
UT WOS:000609931900001
PM 33480168
DA 2026-07-24
ER
PT J
AU Ramser, M
   Glauser, PM
   Glass, TR
   Weixler, B
   Grapow, MTR
   Hoffmann, H
   Kirchhoff, P
AF Ramser, Michaela
   Glauser, Philippe M.
   Glass, Tracy R.
   Weixler, Benjamin
   Grapow, Martin T. R.
   Hoffmann, Henry
   Kirchhoff, Philipp
TI Abdominal Decompression after Cardiac Surgery: Outcome of 42 Patients
   with Abdominal Compartment Syndrome
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
AB Background Up to 50% of patients in intensive care units develop intraabdominal hypertension (IAH) in the course of medical treatment. If not detected on time and treated adequately, IAH may develop into an abdominal compartment syndrome (ACS) which is associated with a high mortality rate. Patients undergoing cardiac surgery are especially prone to develop ACS due to several risk factors including intraoperative hypothermia, fluid resuscitation and acidosis. We investigated patients who developed ACS after cardiac surgery and analyzed potential risk factors, treatment and outcome. Methods From 2011 to 2016, patients with ACS after cardiac surgery requiring decompressive laparotomy were prospectively recorded. Patient characteristics, details on the cardiac surgery, mortality rate and type of treatment of the open abdomen were analyzed. Results Incidence of ACS in cardiac surgery patients was 1.0% (n = 42/4128), with a mortality rate of 57%. Ejection fraction, Euroscore2 as well as the perfusion time are independent risk factors for the development of ACS. The outcome of patients with ACS was independent of elective versus emergency surgery, gender, age, BMI or ASA score. In the 18 surviving patients, fascial closure was achieved in 72% after a median of 9 days. Conclusion Abdominal compartment syndrome is a rare but serious complication after cardiac surgery with a high mortality rate. Independent risk factors for ACS were identified. Negative pressure wound therapy seems to promote and allow early fascia closure of the abdomen and represents therefore a likely benefit for the patient.
C1 [Ramser, Michaela; Glauser, Philippe M.] Univ Hosp Basel, Dept Surg, Basel, Switzerland.
   [Ramser, Michaela] Kantonsspital Olten, Solothurner Spitaler, Dept Surg, Olten, Switzerland.
   [Glauser, Philippe M.] Spital Dornach, Solothurner Spitaler, Dept Surg, Dornach, Switzerland.
   [Glass, Tracy R.] Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
   [Glass, Tracy R.; Weixler, Benjamin; Hoffmann, Henry; Kirchhoff, Philipp] Univ Basel, Basel, Switzerland.
   [Weixler, Benjamin] Charite, Dept Surg, Berlin, Germany.
   [Grapow, Martin T. R.] Univ Hosp Basel, Dept Cardiac Surg, Basel, Switzerland.
   [Grapow, Martin T. R.] HerzZentrum, Hirslanden Klin Zurich, Zurich, Switzerland.
   [Hoffmann, Henry; Kirchhoff, Philipp] ZweiChirurgen, Ctr Hernia Surg & Proctol, Basel, Switzerland.
C3 University of Basel; Kantonsspital Olten; Swiss School of Public Health
   (SSPH+); University of Basel; Swiss Tropical & Public Health Institute;
   University of Basel; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; University of Basel
RP Ramser, M (通讯作者)，Univ Hosp Basel, Dept Surg, Basel, Switzerland.; Ramser, M (通讯作者)，Kantonsspital Olten, Solothurner Spitaler, Dept Surg, Olten, Switzerland.
EM michaela.ramser@spital.so.ch
RI ; Glass, Tracy/D-5046-2017
OI Raer, Michaela/0000-0002-3139-1898; Grapow, Martin/0000-0001-6316-0691;
   Glass, Tracy/0000-0001-7075-9803
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NR 50
TC 9
Z9 10
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD APR
PY 2021
VL 45
IS 4
BP 1242
EP 1251
DI 10.1007/s00268-020-05917-0
EA JAN 2021
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QP8DO
UT WOS:000609979600005
PM 33481080
DA 2026-07-24
ER
PT J
AU Facchin, F
   Pagani, A
   Marchica, P
   Pandis, L
   Scarpa, C
   Brambullo, T
   Bassetto, F
   Vindigni, V
AF Facchin, Federico
   Pagani, Andrea
   Marchica, Paolo
   Pandis, Laura
   Scarpa, Carlotta
   Brambullo, Tito
   Bassetto, Franco
   Vindigni, Vincenzo
TI The Role of Portable Incisional Negative Pressure Wound Therapy (piNPWT)
   in Reducing Local Complications of Post-bariatric Brachioplasty: A
   Case-Control Study
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Body-contouring; Post-bariatric patients; Surgical site complications;
   Obesity; Brachioplasty; Wound care
AB Background Due to the great impact of bariatric surgery on the overweight epidemic, the number of post-bariatric body-contouring procedures is constantly increasing worldwide. The portable incisional negative pressure wound therapy (piNPWT) is a promising medical device for accelerating wounds closure and controlling post-operative complication, which have been shown promising results in post-bariatric population. We aimed to evaluate the role of piNPWT in optimizing wound healing and controlling post-operative complications after a post-bariatric brachioplasty.
   Patients and Methods 26 post-bariatric female patients who underwent a brachioplasty followed by either a piNPWT (14 cases) or a standard wound treatment (12 controls) were analyzed. The number of post-operative dressing changes, the rate of local post-operative complications (re-operation, hematoma and serosa development, dehiscence and necrosis), the time to dry as well as the scar quality and hospitalization length were evaluated.
   Results None of the patients prematurely stopped treatment with piNPWT due to intolerance. The piNPWT patient group showed a significant lower healing time as well as a significant reduction of the number of post-operative dressing changes and hospital stay. Despite the scarring process was excellent from the functional point of view in the long term, we noticed a higher rate of hyperchromic scarring at 90 days after surgery.
   Conclusion The piNPWT is a cost-effective and user-friendly medical tool that increase and promote wound healing. We suggest the use of this device in post-bariatric patients who undergo a brachioplasty, especially if there is the need to minimize the number of post-operative dressing changes.
C1 [Facchin, Federico; Marchica, Paolo; Pandis, Laura; Scarpa, Carlotta; Brambullo, Tito; Bassetto, Franco; Vindigni, Vincenzo] Univ Padua, Plast & Reconstruct Surg Unit, Via Nicolo Giustininani 2, I-35128 Padua, Italy.
   [Pagani, Andrea] Tech Univ Munich, Clin & Policlin Plast & Hand Surg, Ismaninger Str 22, D-81675 Munich, Germany.
C3 University of Padua; Technical University of Munich
RP Facchin, F (通讯作者)，Univ Padua, Plast & Reconstruct Surg Unit, Via Nicolo Giustininani 2, I-35128 Padua, Italy.
EM federicofacchin@yahoo.it; andrea.pagani@studenti.unipd.it;
   paolomarchica91@gmail.com; laura.pandis@aopd.veneto.it;
   carlotta.scarpa@unipd.it; tito.brambullo@aopd.veneto.it;
   franco.bassetto@unipd.it; vincenzo.vindigni@unipd.it
RI Marchica, Paolo/NQF-8611-2025; Brambullo, Tito/AAZ-2332-2020; Scarpa,
   Carlotta/HJG-7233-2022; Vindigni, Vincenzo/K-5059-2016; Facchin,
   Federico/GLN-4990-2022
OI Marchica, Paolo/0000-0002-2108-2979; Brambullo,
   Tito/0000-0002-1041-9660; Facchin, Federico/0000-0002-6695-1103
FU Universita` degli Studi di Padova
FX Open Access funding provided by Universita` degli Studi di Padova. No
   funding has been received in support of the paper
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
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NR 37
TC 7
Z9 8
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD AUG
PY 2021
VL 45
IS 4
BP 1653
EP 1659
DI 10.1007/s00266-020-02122-1
EA JAN 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TQ5EK
UT WOS:000609999600001
PM 33481062
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Serena, TE
   Jalodi, O
   Serena, L
   Patel, K
   Mynti, M
AF Serena, Thomas E.
   Jalodi, Omar
   Serena, Laura
   Patel, Keyur
   Mynti, Matthew
TI Evaluation of the combination of a biofilm-disrupting agent and negative
   pressure wound therapy: a case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE biofilm; dressing; negative pressure wound therapy; pressure injuries;
   pressure ulcers; wound; wound care; wound healing; wounds
ID VACUUM-ASSISTED CLOSURE; CARE
AB Objective: Approximately three million people in the US have hardto-heal pressure ulcers (PUs), including 10% of hospitalised patients. Healing depends on ulcer stage and patient comorbidities. Despite advances in nutrition and wound care, PUs can take months or years to reach complete closure. To date, clinical studies have focused on single modality therapy. However, there is no one therapy that can address all of the deficits in these complex, hard-to-heal wounds. A commonly used treatment for PUs, negative pressure wound therapy (NPWT), has demonstrated improved healing in Stage 3 and 4 PUs. NPWT entails applying suction to a porous sponge fitted into the wound cavity and sealed with an occlusive dressing. Negative pressure facilitates wound healing by removing wound fluid containing harmful proteases, stimulating the formation of granulation tissue and promoting wound contracture. However, it does not affect biofilm formation. We hypothesised that adding an antibiofilm agent might increase the effectiveness of NPWT in recalcitrant PUs.
   Method: A prospective case series was conducted in outpatient wound care centres and a skilled nursing facility to examine the combination of a biofilm disrupting antimicrobial agent (Blast-X, Next Science, US) in combination with NPWT (VAC, 3M, US) in healing and reducing bacterial burden in treatment-resistant pressure ulcers. Patients consented to application of the antibiofilm agent and NPWT three times per week for four weeks. The wounds were measured, imaged for bacteria and tested for host and bacterial protease activity weekly.
   Results: Of the 10 patients, four dropped out of the study before the end of the four weeks. Of the remaining six, four patients experienced a reduction in wound surface area and volume, reduced protease activity and lower bacterial levels.
   Conclusion: The results of this study showed that multimodal therapy, including NPWT and biofilm disruption, may restart the healing of stagnant treatment-resistant PUs.
C1 [Serena, Thomas E.; Jalodi, Omar; Serena, Laura] SerenaGrp Res Fdn, Cambridge, MA 02140 USA.
   [Patel, Keyur] D&P Med Grp, Pittsburgh, PA USA.
   [Mynti, Matthew] Next Sci Inc, Chatswood, NSW, Australia.
RP Serena, TE (通讯作者)，SerenaGrp Res Fdn, Cambridge, MA 02140 USA.
EM serena@serenagroups.com
CR Agency for Healthcare Research and Quality, 2014, PREV PRESS ULC HOSP
   [Anonymous], 2009, TREATM PRESS ULC QUI
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NR 24
TC 12
Z9 13
U1 2
U2 10
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2021
VL 30
IS 1
BP 9
EP 14
DI 10.12968/jowc.2021.30.1.9
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA PW8TW
UT WOS:000610941500004
PM 33439086
DA 2026-07-24
ER
PT J
AU Rickert, M
   Rauschmann, M
   Latif-Richter, N
   Arabmotlagh, M
   Rahim, T
   Schmidt, S
   Fleege, C
AF Rickert, Marcus
   Rauschmann, Michael
   Latif-Richter, Nizar
   Arabmotlagh, Mohammad
   Rahim, Tamin
   Schmidt, Sven
   Fleege, Christoph
TI Management of Deep Spinal Wound Infections Following Instrumentation
   Surgery with Subfascial Negative Pressure Wound Therapy
SO JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
LA English
DT Article
DE spinal surgery; infection risk factors; postoperative wound infection;
   negative pressure wound therapy
ID SURGICAL SITE INFECTIONS; RISK-FACTORS; NOSOCOMIAL INFECTIONS; LUMBAR
   FUSION; DIAGNOSIS; GERMANY; CLOSURE; PREVALENCE; ADULTS
AB Background and Study Aims The treatment of infections following a spine surgery continues to be a challenge. Negative pressure wound therapy (NPWT) has been an effective method in the context of infection therapy, and its use has gained popularity in recent decades. This study aims to analyze the impact of known risk factors for postoperative wound infection on the efficiency and length of NPWT therapy until healing.
   Patients and Methods We analyzed 50 cases of NPWT treatment for deep wound infection after posterior and posteroanterior spinal fusion from March 2010 to July 2014 retrospectively. We included 32 women and 18 men with a mean age of 69 years (range, 36-87 years). Individual risk factors for postoperative infection, such as age, gender, obesity, diabetes, immunosuppression, duration of surgery, intraoperative blood loss, and previous surgeries, as well as type and onset (early vs. late) of the infection were analyzed. We assessed the associations between these risk factors and the number of revisions until wound healing.
   Results In 42 patients (84%), bacterial pathogens were successfully detected by means of intraoperative swabs and tissue samples during first revision. A total of 19 different pathogens could be identified with a preponderance of Staphylococcus epidermidis (21.4%) and S. aureus (19.0%). Methicillin-resistant S. aureus (MRSA) was recorded in two patients (2.6%). An average of four NPWT revisions was required until the infection was cured. Patients with infections caused by mixed pathogens required a significantly higher number of revisions (5.3 vs. 3.3; p <0.01) until definitive wound healing. For the risk factors, no significant differences in the number of revisions could be demonstrated when compared with the patients without the respective risk factor.
   Conclusion NPWT was an effective therapy for the treatment of wound infections after spinal fusion. All patients in the study had their infections successfully cured, and all spinal implants could be retained. The number of revisions was similar to those reported in the published literature. The present study provides insights regarding the effectiveness of NPWT for the treatment of deep wound infection after spinal fusion. Further investigations on the impact of potential risk factors for postoperative wound healing disorders are required. Better knowledge on the impact of specific risk factors will contribute to a higher effectiveness of prophylaxis for postoperative wound infections considering the patient-specific situation.
C1 [Rickert, Marcus] Schon Klin Lorsch, Spine Dept, Wilhelm Leuschner Str 10, D-64653 Lorsch, Germany.
   [Rauschmann, Michael; Arabmotlagh, Mohammad; Schmidt, Sven] Sana Klinikum Offenbach GmbH, Wirbelsaulenorthopadie & Rekonstrukt Orthopadie, Offenbach, Hessen, Germany.
   [Latif-Richter, Nizar; Fleege, Christoph] Orthopad Univ Klin Friedrichsheim gGmbH, Dept Orthoped, Frankfurt, Hessen, Germany.
   [Rahim, Tamin] Neurosurg Wiesbaden, Dept Neurosurg, Wiesbaden, Germany.
C3 Sana Klinikum Offenbach
RP Rickert, M (通讯作者)，Schon Klin Lorsch, Spine Dept, Wilhelm Leuschner Str 10, D-64653 Lorsch, Germany.
EM marcusrickert@gmx.de
OI Arabmotlagh, Mohammad/0000-0002-7648-7412
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NR 43
TC 5
Z9 8
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 2193-6315
EI 2193-6323
J9 J NEUROL SURG PART A
JI J. Neurol. Surg. Part A
PD JAN
PY 2023
VL 84
IS 01
BP 30
EP 36
DI 10.1055/s-0040-1720999
EA JAN 2021
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 7W2VH
UT WOS:000612195700001
PM 33506474
DA 2026-07-24
ER
PT J
AU Pagani, NR
   Moverman, MA
   Puzzitiello, RN
   Menendez, ME
   Kavolus, JJ
AF Pagani, Nicholas R.
   Moverman, Michael A.
   Puzzitiello, Richard N.
   Menendez, Mariano E.
   Kavolus, Joseph J.
TI The Cost-Effectiveness of Closed Incisional Negative Pressure Wound
   Therapy for Infection Prevention after Revision Total Knee Arthroplasty
SO JOURNAL OF KNEE SURGERY
LA English
DT Article
DE prosthetic joint infection; revision; total knee arthroplasty; cost;
   negative pressure wound therapy
ID TOTAL HIP; COMPLICATIONS; SURGERY; DRESSINGS; DRAINAGE; BURDEN
AB Recent investigations have shown that closed incisional negative pressure wound therapy (ciNPWT) decreases the rate of postoperative wound complications following revision total knee arthroplasty (TKA). In this study, we used a break-even analysis to determine whether ciNPWT is a cost-effective measure for reducing prosthetic joint infection (PJI) after revision TKA. The cost of ciNPWT, cost of treatment for PJI, and baseline infection rates following revision TKA were collected from institutional data and the literature. The absolute risk reduction (ARR) in infection rate necessary for cost-effectiveness was calculated using break-even analysis. Using our institutional cost of ciNPWT ($600), this intervention would be cost-effective if the initial infection rate of revision TKA (9.0%) has an ARR of 0.92%. The ARR needed for cost-effectiveness remained constant across a wide range of initial infection rates and declined as treatment costs increased. The use of ciNPWT for infection prevention following revision TKA is cost-effective at both high and low initial infection rates, across a broad range of treatment costs, and at inflated product expenses.
C1 [Pagani, Nicholas R.; Moverman, Michael A.; Puzzitiello, Richard N.; Menendez, Mariano E.; Kavolus, Joseph J.] Tufts Med Ctr, Dept Orthopaed Surg, 800 Washington St, Boston, MA 02111 USA.
C3 Tufts Medical Center
RP Pagani, NR (通讯作者)，Tufts Med Ctr, Dept Orthopaed Surg, 800 Washington St, Boston, MA 02111 USA.
EM npagani@tuftsmedicalcenter.org
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NR 42
TC 3
Z9 3
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 1538-8506
EI 1938-2480
J9 J KNEE SURG
JI J. Knee Surg.
PD OCT
PY 2022
VL 35
IS 12
BP 1301
EP 1305
DI 10.1055/s-0041-1724137
EA JAN 2021
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 5E3KB
UT WOS:000612582100008
PM 33511588
DA 2026-07-24
ER
PT J
AU Hofmann, AT
   May, C
   Glaser, K
   Fortelny, RH
AF Hofmann, Anna Theresa
   May, Christopher
   Glaser, Karl
   Fortelny, Rene H.
TI Delayed Closure of Open Abdomen in Septic Patients Treated With Negative
   Pressure Vacuum Therapy and Dynamic Sutures: A 10-Years Follow-Up on
   Long-Term Complications
SO FRONTIERS IN SURGERY
LA English
DT Article
DE open abdomen; negative pressure wound therapy; delayed fascial closure;
   dynamic fascial suture; incisional hernia
ID ASSISTED WOUND CLOSURE; FASCIAL CLOSURE; HERNIA RATE; MANAGEMENT
AB Introduction: Patients with open abdomen after surgical interventions associated with the complication of secondary peritonitis are successfully treated with negative pressure wound therapy. The use of dynamic fascial sutures reduces fascial lateralization and increases successful delayed fascial closure after open abdomen treatment.
   Methods: In 2017 we published the follow-up results of 38 survivors out of 87 open abdomen patients treated with negative pressure wound therapy and dynamic fascial sutures between 2007 and 2012. In our current study we present the 10-years follow-up results regarding long-term complications with the focus on incisional hernias and pain. Since 2017 seven more patients have died, hence 31 patients were included in the current study. The patients were asked to answer questions about specific long-term complications of OA treatment including pain, the presence of incisional hernias and subsequent surgical interventions. Demographic data and data regarding fascial closure after open abdomen treatment were collected. All results were analyzed quantitatively. The follow-up period was 8-13 years.
   Results: The median age was 69 (30-90) years, and 15 (48.4%) were females. Twenty-four patients (77.4%) responded to the questionnaire: Three patients (12.5%) suffered from pain in the original operating field, all three at rest but not during exercise. None of the patients required analgesic treatment. Eleven patients (45.8%) were found to have incisional hernias. Five out of 11 hernias (45.5%) were treated by surgery and did not declare any pain in the operating field. Among the patients with incisional hernias lower MPI (Mannheimer Peritonitis Index) at the time of primary surgery but more reoperations and treatment days were found. The technique of fascial closure was heterogenic and no differences in the occurrence of incisional hernia could be detected.
   Conclusion: The incidence of incisional hernias after open abdomen treatment is still high, but are associated with little pain in the original operating field. Further studies are required to investigate methods for fascial closure techniques after OA treatment.
C1 [Hofmann, Anna Theresa; May, Christopher; Glaser, Karl; Fortelny, Rene H.] Klin Ottakring, Dept Gen Visceral & Oncol Surg, Vienna, Austria.
   [Fortelny, Rene H.] Sigmund Freud Private Univ, Med Fac, Vienna, Austria.
RP Hofmann, AT (通讯作者)，Klin Ottakring, Dept Gen Visceral & Oncol Surg, Vienna, Austria.
EM anna.hofmann@gesundheitsverbund.at
RI Fortelny, René/AAD-5922-2021
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NR 25
TC 4
Z9 5
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JAN 15
PY 2021
VL 7
AR 611905
DI 10.3389/fsurg.2020.611905
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA PZ3SF
UT WOS:000612658300001
PM 33521047
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kim, KJ
   Min, JH
   Yoo, I
   Kim, SW
   Lee, J
   Ryu, S
   You, YH
   Park, JS
   Jeong, WJ
   Cho, YC
   Oh, SK
   In, YN
   Ahn, HJ
   Kang, CS
   Kyung, H
   Lee, BK
   Lee, DH
   Lee, DH
AF Kim, Kwan Jae
   Min, Jin Hong
   Yoo, Insool
   Kim, Seung Whan
   Lee, Jinwoong
   Ryu, Seung
   You, Yeon Ho
   Park, Jung Soo
   Jeong, Won Joon
   Cho, Yong Chul
   Oh, Se Kwang
   In, Yong Nam
   Ahn, Hong Joon
   Kang, Chang Shin
   Kyung, Hyunwoo
   Lee, Byung Kook
   Lee, Dong Hun
   Lee, Dong Hoon
TI Negative pressure wound therapy for skin necrosis prevention after
   snakebite in the emergency department A retrospective cohort study
SO MEDICINE
LA English
DT Article
DE edema; negative pressure wound therapy; skin necrosis; snakebites; wound
   infection
ID VACUUM-ASSISTED CLOSURE; MECHANISM; EFFICACY; CELLS; MNSOD; BITE; NPWT
AB This retrospective cohort study aimed to compare the effectiveness of conventional treatment and ultra-early application of negative pressure wound therapy (NPWT) in patients with snakebites. Patients who visited the emergency department within 24 hours after a snakebite were assigned to the non- NPWT or NPWT group. Swelling resolution time and rates of necrosis, infection, and operations were compared between the 2 groups. The Stony Brook Scar Evaluation Scale was used to measure short- and long-term wound healing results. Among the included 61 patients, the swelling resolution time was significantly shorter in the NPWT group than in non- NPWT group (P = .010). The NPWT group showed lower necrosis (4.3% versus 36.8%; P = .003) and infection (13.2% and 4.3%; P = .258) rates than the non- NPWT group. The median Stony Brook Scar Evaluation Scale scores were higher in the NPWT group than in the non- NPWT group (P< .001). These findings suggest that ultra-early application of NPWT reduces edema, promotes wound healing, and prevents necrosis in patients with snakebites.
C1 [Kim, Kwan Jae; Yoo, Insool; Kim, Seung Whan; Lee, Jinwoong; Ryu, Seung; You, Yeon Ho; Park, Jung Soo; Jeong, Won Joon; Cho, Yong Chul; Ahn, Hong Joon; Kang, Chang Shin] Chungnam Natl Univ Hosp, Dept Emergency Med, Daejeon, South Korea.
   [Min, Jin Hong; Yoo, Insool; Kim, Seung Whan; Park, Jung Soo] Chungnam Natl Univ, Dept Emergency Med, Coll Med, 266 Munhwa Ro, Daejeon, South Korea.
   [Min, Jin Hong; Oh, Se Kwang; In, Yong Nam] Chungnam Natl Univ, Sejong Hosp, Dept Emergency Med, 7 Bodam Ro, Sejong, South Korea.
   [Kyung, Hyunwoo] Chungnam Natl Univ, Sejong Hosp, Dept Plast Surg, 7 Bodam Ro, Sejong, South Korea.
   [Lee, Byung Kook] Chonnam Natl Univ, Dept Emergency Med, Sch Med, Gwangju, South Korea.
   [Lee, Byung Kook; Lee, Dong Hun] Chonnam Natl Univ Hosp, Dept Emergency Med, 42 Jebong Ro, Gwangju, South Korea.
   [Lee, Dong Hoon] Chung Ang Univ, Dept Emergency Med, Coll Med, 47 Heukseok Ro, Seoul, South Korea.
C3 Chungnam National University; Chungnam National University Hospital;
   Chungnam National University; Chungnam National University; Chungnam
   National University; Chonnam National University; Chonnam National
   University; Chonnam National University Hospital; Chung Ang University;
   Chung Ang University Hospital
RP Min, JH (通讯作者)，Chungnam Natl Univ, Dept Emergency Med, Coll Med, 266 Munhwa Ro, Daejeon, South Korea.
EM laphir@cnu.ac.kr
RI Kang, Changshin/AAS-9279-2021; Lee, Byung Kook/M-2236-2018; Lee,
   Jinwoong/OUJ-6622-2025
OI Lee, Byung Kook/0000-0003-3571-9448; Lee, Jinwoong/0000-0002-2431-1351
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NR 37
TC 8
Z9 10
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN 22
PY 2021
VL 100
IS 3
AR e24290
DI 10.1097/MD.0000000000024290
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PZ6FV
UT WOS:000612835100135
PM 33546055
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ordoñez, CA
   Parra, MW
   Millán, M
   Caicedo, Y
   Padilla, N
   Guzmán-Rodríguez, M
   Miñan-Arana, F
   García, A
   González-Hadad, A
   Pino, LF
   Rodríguez-Holguin, F
   Serna, JJ
   Salcedo, A
   Ferrada, R
   Ivatury, R
AF Ordonez, Carlos A.
   Parra, Michael W.
   Millan, Mauricio
   Caicedo, Yaset
   Padilla, Natalia
   Guzman-Rodriguez, Monica
   Minan-Arana, Fernando
   Garcia, Alberto
   Gonzalez-Hadad, Adolfo
   Fernando Pino, Luis
   Rodriguez-Holguin, Fernando
   Julian Serna, Jose
   Salcedo, Alexander
   Ferrada, Ricardo
   Ivatury, Rao
TI Pancreatic damage control: the pancreas is simple don't complicate it
SO COLOMBIA MEDICA
LA English
DT Article
DE Pancreatic Damage Control; Suture; Drainage; Pancreatic Fistula;
   Pancreatectomy; Peritoneal Cavity; Amylases; Ampulla of Vater; Enteral
   Nutrition; Splenectomy; Negative-Pressure Wound Therapy; Critical
   Illness; Cholecystostomy; Operating Rooms; Laparotomy; Lacerations
ID MANAGEMENT; TRAUMA; TOMOGRAPHY
AB Pancreatic trauma is a rare but potentially lethal injury because often it is associated with other abdominal organ or vascular injuries. Usually, it has a late clinical presentation which in turn complicates the management and overall prognosis. Due to the overall low prevalence of pancreatic injuries, there has been a significant lack of consensus among trauma surgeons worldwide on how to appropriately and efficiently diagnose and manage them. The accurate diagnosis of these injuries is difficult due to its anatomical location and the fact that signs of pancreatic damage are usually of delayed presentation. The current surgical trend has been moving towards organ preservation in order to avoid complications secondary to exocrine and endocrine function loss and/or potential implicit post-operative complications including leaks and fistulas. The aim of this paper is to propose a management algorithm of patients with pancreatic injuries via an expert consensus. Most pancreatic injuries can be managed with a combination of hemostatic maneuvers, pancreatic packing, parenchymal wound suturing and closed surgical drainage. Distal pancreatectomies with the inevitable loss of significant amounts of healthy pancreatic tissue must be avoided. General principles of damage control surgery must be applied when necessary followed by definitive surgical management when and only when appropriate physiological stabilization has been achieved. It is our experience that viable un-injured pancreatic tissue should be left alone when possible in all types of pancreatic injuries accompanied by adequate closed surgical drainage with the aim of preserving primary organ function and decreasing short and long term morbidity.
C1 [Ordonez, Carlos A.; Garcia, Alberto; Rodriguez-Holguin, Fernando; Julian Serna, Jose; Salcedo, Alexander] Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Ordonez, Carlos A.; Garcia, Alberto; Gonzalez-Hadad, Adolfo; Fernando Pino, Luis; Julian Serna, Jose; Salcedo, Alexander; Ferrada, Ricardo] Univ Valle, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Ordonez, Carlos A.; Millan, Mauricio; Rodriguez-Holguin, Fernando; Julian Serna, Jose; Salcedo, Alexander] Univ Icesi, Cali, Colombia.
   [Parra, Michael W.] Broward Gen Level I Trauma Ctr, Dept Trauma Crit Care, Ft Lauderdale, FL USA.
   [Millan, Mauricio] Fdn Valle Lili, Dept Surg, Div Transplant Surg, Cali, Colombia.
   [Caicedo, Yaset; Padilla, Natalia] Fdn Valle Lili, Ctr Invest Clin CIC, Cali, Colombia.
   [Guzman-Rodriguez, Monica] Univ Chile, Fac Med, Inst Ciencias Biomed, Santiago, Chile.
   [Minan-Arana, Fernando] Univ Espiritu Santo, Dept Surg, Guayaquil, Ecuador.
   [Minan-Arana, Fernando] Hosp Dr Abel Gilbert Ponton, Dept Surg, Div Trauma & Acute Care Surg, Guayaquil, Ecuador.
   [Garcia, Alberto; Gonzalez-Hadad, Adolfo; Fernando Pino, Luis; Julian Serna, Jose; Salcedo, Alexander] Hosp Univ Valle, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Gonzalez-Hadad, Adolfo; Ferrada, Ricardo] Ctr Med Imbanaco, Cali, Colombia.
   [Ivatury, Rao] Virginia Commonwealth Univ, Richmond, VA USA.
C3 Fundacion Valle del Lili; Universidad del Valle; Universidad ICESI;
   Fundacion Valle del Lili; Fundacion Valle del Lili; Universidad de
   Chile; Universidad de Especialidades Espiritu Santo; Universidad del
   Valle; Virginia Commonwealth University
RP Ordoñez, CA (通讯作者)，Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.; Ordoñez, CA (通讯作者)，Univ Valle, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.; Ordoñez, CA (通讯作者)，Univ Icesi, Cali, Colombia.
EM ordonezcarlosa@gmail.com
OI Padilla-Londoño, Natalia/0000-0003-3292-6919; PINO OLIVEROS, LUIS
   FERNANDO/0000-0002-1179-2854
CR Ahmed N, 2009, SOUTH MED J, V102, P1253, DOI 10.1097/SMJ.0b013e3181c0dfca
   Ordoñez CA, 2012, J TRAUMA ACUTE CARE, V73, P1074, DOI 10.1097/TA.0b013e31826fc780
   de Carvalho MEAJ, 2020, INJURY, V51, P592, DOI 10.1016/j.injury.2020.01.018
   Asensio JA, 2003, J AM COLL SURGEONS, V197, P937, DOI 10.1016/j.jamcollsurg.2003.07.019
   Ball CG, 2010, J GASTROINTEST SURG, V14, P1632, DOI 10.1007/s11605-010-1286-8
   Byrge N, 2018, J TRAUMA ACUTE CARE, V85, P435, DOI 10.1097/TA.0000000000001987
   Coccolini F, 2019, WORLD J EMERG SURG, V14, DOI 10.1186/s13017-019-0278-6
   Girard E, 2016, J VISC SURG, V153, P259, DOI [10.1016/j.jchirv.2016.02.002, 10.1016/j.jviscsurg.2016.02.006]
   Iacono C, 2016, PANCREATOLOGY, V16, P302, DOI 10.1016/j.pan.2015.12.004
   Jurkovich GJ, 2020, J TRAUMA ACUTE CARE, V88, P19, DOI 10.1097/TA.0000000000002546
   Krige J, 2017, J VISC SURG, V154, P141, DOI 10.1016/j.jviscsurg.2017.02.002
   Krige JEJ, 2017, EUR J TRAUMA EMERG S, V43, P411, DOI 10.1007/s00068-016-0657-6
   Larsen JW, 2019, INJURY, V50, P1787, DOI 10.1016/j.injury.2019.08.010
   MOORE EE, 1990, J TRAUMA, V30, P1427, DOI 10.1097/00005373-199011000-00035
   Ordoñez C, 2020, COLOMB MEDICA, V51
   Osborn LA, 2019, OPEN ACCESS EMERG M, V11, P29, DOI 10.2147/OAEM.S166087
   Panda A, 2015, ACTA RADIOL, V56, P387, DOI 10.1177/0284185114529949
   Petrone P, 2017, CIR ESPAN, V95, P123, DOI 10.1016/j.ciresp.2016.05.011
   Potoka DA, 2015, EUR J TRAUMA EMERG S, V41, P239, DOI 10.1007/s00068-015-0510-3
   Rodriguez Fernando, 2015, Panam J Trauma Crit Care Emerg Surg, V4, P147, DOI [10.5005/jp-journals-10030-1129, 10.5005/jp-journals-10030-1129]
   Schellenberg M, 2018, AM J SURG, V216, P299, DOI 10.1016/j.amjsurg.2018.06.002
   Sharpe JP, 2012, J TRAUMA ACUTE CARE, V72, P100, DOI 10.1097/TA.0b013e318241f09d
   Shibahashi K, 2020, INJURY, V51, P59, DOI 10.1016/j.injury.2019.08.009
   Vasquez JC, 2001, INJURY, V32, P753, DOI 10.1016/S0020-1383(01)00099-7
   Vasquez M, 2017, MIL MED, V182, P66, DOI 10.7205/MILMED-D-16-00084
NR 25
TC 11
Z9 12
U1 0
U2 1
PU CORPORACION EDITORA MEDICA VALLE
PI CALI
PA UNIV VALLE, BLDG 118 FACULTY HEALTH, CALLE 4B 36-00, CALI, 00000,
   COLOMBIA
SN 1657-9534
J9 COLOMB MEDICA
JI Colomb. Medica
PY 2020
VL 51
IS 4
AR e-4054361
DI 10.25100/cm.v51i4.4361
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PZ8US
UT WOS:000613024700004
PM 33795904
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Montero, EC
   Jerónimo, LP
   Vazquez, AP
   Marín, LR
   Villarpando, PES
   Dobao, PD
AF Conde Montero, Elena
   Perez Jeronimo, Laura
   Peral Vazquez, Alicia
   Recarte Marin, Lorena
   Sanabria Villarpando, Pablo Ernesto
   de la Cueva Dobao, Pablo
TI Early and Sequential Punch Grafting in the Spectrum of Arteriolopathy
   Ulcers in the Elderly
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE Martorell ulcer; pain; punch grafting; arteriolosclerosis; posttraumatic
ID LEG
AB Introduction. Posttraumatic ulcers secondary to age-related arteriolosclerosis may be included in the clinic-histopathological spectrum of the Martorell hypertensive ischemic ulcer. Histologically, they both present occlusive subcutaneous arteriolosclerosis. Considering these similarities, they could benefit from the same treatment. Case Report. The authors present an 84-year-old white female who had a painful 9-cm x 4-cm ulcer of the central inner aspect of her left leg. The ulcer had developed 2 months prior after mild trauma, with good response to early and sequential punch grafting, combined with single-use negative pressure wound therapy and compression therapy. Pain reduction was obtained from the first punch grafting session. To achieve complete epithelialization 16 weeks after the first punch grafting procedure, 2 more sessions were necessary. Conclusions. Early punch grafting is an effective technique for pain control and healing promotion in Martorell ulcers. Punch grafting, which may be performed in an outpatient setting, is well tolerated by patients and may be repeated several times if necessary.
C1 [Conde Montero, Elena; Perez Jeronimo, Laura; de la Cueva Dobao, Pablo] Hosp Univ Infanta Leonor, Dept Dermatol, Madrid, Spain.
   [Conde Montero, Elena; Perez Jeronimo, Laura; de la Cueva Dobao, Pablo] Hosp Virgen de la Torre, Madrid, Spain.
   [Peral Vazquez, Alicia; Recarte Marin, Lorena] Ctr Especialidades Vicente Soldevilla, Madrid, Spain.
   [Sanabria Villarpando, Pablo Ernesto] Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina.
C3 Hospital Universitario Infanta Leonor; Hospital Universitario Infanta
   Leonor; Hospital Italiano de Buenos Aires; University of Buenos Aires;
   University of Buenos Aires Hospital
RP Montero, EC (通讯作者)，Hosp Univ Infanta Leonor, Dept Dermatol, Madrid, Spain.
EM elenacondemontero@gmail.com
CR Montero EC, 2018, WOUNDS, V30, pE9
   Fernández-Ginés FD, 2017, AM J HEALTH-SYST PH, V74, pE176, DOI 10.2146/ajhp151008
   Fourgeaud C, 2016, J Mal Vasc, V41, P329, DOI [10.1016/j.jmv.2016.08.002, 10.1016/j.jmv.2016.08.002]
   Muñoz SG, 2019, ACTAS DERMO-SIFILOGR, V110, P689, DOI 10.1016/j.ad.2018.06.016
   Haute Autorite de Sante, 2006, PRIS CHARG ULC JAMB
   Imbernón-Moya A, 2016, INT WOUND J, V13, P1060, DOI 10.1111/iwj.12474
   Isoherranen K, 2019, J WOUND CARE, V28, pS1, DOI 10.12968/jowc.2019.28.Sup6.S1
   Martinez Monsalve ARMJ, 2012, REV ELECT ANEST, V4, P181
   Monfort JB, 2018, DERMATOLOGY, V234, P194, DOI 10.1159/000492669
   Nordström A, 2008, ACTA DERM-VENEREOL, V88, P389, DOI 10.2340/00015555-0443
   Rock KL, 2008, ANNU REV PATHOL-MECH, V3, P99, DOI 10.1146/annurev.pathmechdis.3.121806.151456
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 12
TC 8
Z9 9
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2020
VL 32
IS 8
BP E38
EP E41
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QA6LH
UT WOS:000613554600001
PM 33166269
DA 2026-07-24
ER
PT J
AU Aparicio-Sánchez, D
   Pintor-Tortolero, J
   Perea-Del Pozo, E
   Tallón-Aguilar, L
   Padillo-Ruiz, FJ
AF Aparicio-Sanchez, Daniel
   Pintor-Tortolero, Jose
   Perea-Del Pozo, Eduardo
   Tallon-Aguilar, Luis
   Javier Padillo-Ruiz, Francisco
TI Association of Negative Pressure Wound Therapy and Dermatotraction for
   Management of Necrotizing Soft Tissue Infections: A Case Series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; dermatotraction; NPWT; wound closure
   techniques; wound infection; necrotizing fasciitis
ID FASCIITIS
AB Introduction. Soft tissue infections (STIs), which include infections of the skin, subcutaneous tissue, fascia, and muscle, encompass a wide variety of heterogeneous pathologies. Treatment of STIs is based on surgical debridement of the affected area. One such treatment, negative pressure wound therapy (NPWT), has improved the management of STIs. Objective. The purpose of this study is to assess the safety and utility of NPWT in conjunction with dermatotraction in the early stage management of necrotizing STIs. Materials and Methods. The authors report a retrospective series of 3 cases in which NPWT and dermatotraction (NPWT-D) were used in an attempt to manage necrotizing STI. The NPWT-D device combination was employed to approximate the edges of the wounds. The NPWT device was changed every 2 or 3 days, and dermatotraction tension was adjusted concurrently. Results. The NPWT-D device changes ranged from 3 to 4 times for 2 of the 3 patients, as 1 patient passed away secondary to STIs and therefore did not receive complete treatment. The total treatment ranged from 8 to 10 days in the remaining 2 patients. In both cases, complete wound closure was achieved while avoiding skin grafts. After 5 days of therapy in the incomplete treatment case, the wound area was reduced by about half. Conclusions. Based on the experiences herein, NPWT-D may be a safe and useful alternative surgical treatment for the management of necrotizing STIs. In the present cases, NPWT-D improved and shortened the wound healing process, and it achieved a tertiary wound closure, thereby avoiding the need for skin grafts.
C1 [Aparicio-Sanchez, Daniel; Pintor-Tortolero, Jose; Perea-Del Pozo, Eduardo; Tallon-Aguilar, Luis] Virgen del Rocio Univ Hosp, Emergency Surg Unit, Seville, Spain.
   [Javier Padillo-Ruiz, Francisco] Virgen del Rocio Univ Hosp, Gen Surg Unit, Seville, Spain.
C3 Virgen del Rocio University Hospital; Virgen del Rocio University
   Hospital
RP Aparicio-Sánchez, D (通讯作者)，Hosp Univ Virgen del Rocio, Serv Cirugia Gen & Aparato Digest, Avda Manuel Siurot S-N, Seville 41013, Spain.
EM daniel.apariciosanchez@gmail.com
RI Aparicio-Sánchez, Daniel/AAC-1266-2020; Tallon-Aguilar,
   Luis/JHV-1215-2023
OI Tallon-Aguilar, Luis/0000-0002-7549-619X; Pintor-Tortolero,
   José/0000-0003-1648-5156
CR Chen SJ, 2019, J ORAL MAXIL SURG, V77, P87, DOI 10.1016/j.joms.2018.08.016
   Gestring M., NEGATIVE PRESSURE WO
   Lee JY, 2014, WORLD J EMERG SURG, V9, DOI 10.1186/1749-7922-9-29
   Madsen MB, 2019, INTENS CARE MED, V45, P1241, DOI 10.1007/s00134-019-05730-x
   Maya SP, 2014, SKELETAL RADIOL, V43, P577, DOI 10.1007/s00256-013-1813-2
   Pintor-Tortolero J, 2019, ANZ J SURG, V89, pE49, DOI 10.1111/ans.14959
   Wong CH, 2003, J BONE JOINT SURG AM, V85A, P1454, DOI 10.2106/00004623-200308000-00005
NR 7
TC 0
Z9 0
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2020
VL 32
IS 8
BP 217
EP 220
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QA6LH
UT WOS:000613554600003
PM 33166261
DA 2026-07-24
ER
PT J
AU Fernández, LG
   Matthews, MR
   Ellman, C
   Jackson, P
   Villarreal, DH
   Norwood, S
AF Fernandez, Luis G.
   Matthews, Marc R.
   Ellman, Cynthia
   Jackson, Patricia
   Villarreal, David H.
   Norwood, Scott
TI Use of Reticulated Open Cell Foam Dressings With Through Holes During
   Negative Pressure Wound Therapy With Instillation and Dwell Time: A
   Large Case Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time;
   reticulated open cell foam dressing with through holes; complex wounds;
   wound healing
AB Introduction. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been utilized in wounds with positive clinical benefits. A reticulated open cell foam dressing with through holes (ROCF-CC) was developed to assist with wound cleansing by removing thick wound exudate and infectious materials, and it may be used when debridement is not possible or appropriate. Use of NPWTi-d with ROCF-CC dressings has been reported with positive outcomes in complex wounds. Objective. The present study reports the authors' experience using NPWTi-d with ROCF-CC dressings in 19 patients with complex wounds. Materials and Methods. Of the 19 patients, 8 underwent sharp debridement. Oral and/or intravenous antibiotic treatment was initiated as needed prior to NPWTi-d. All patients received NPWTi-d with ROCF-CC dressings with instillation of quarter-strength Dakin's solution, hypochlorous acid solution, or saline with a dwell time of 5 to 10 minutes, followed by 2 to 3.5 hours of continuous negative pressure at -125 mm Hg. Dressing changes occurred every 2 to 3 days. Measurements and assessments of wound progression were done as per institutional protocols. Results. The 19 treated patients consisted of 10 males and 9 females, with an average age of 58.2 +/- 15.1 years. Common patient comorbidities included hypertension, diabetes, obesity, and paraplegia. Wound types included pressure injuries, traumatic wounds, and surgical wounds. The average length of NPWTi-d use was 9.5 +/- 4.1 days. In all of the patients, the wound beds showed development of healthy granulation tissue following NPWTi-d with ROCF-CC. All patients were discharged to one of the following: another hospital facility, skilled nursing facility, long-term acute care facility, or home. Conclusions. In the authors' clinical practice, NPWTi-d with ROCF-CC provided effective and rapid removal of thick exudate and infectious materials and promoted development of granulation tissue.
C1 [Fernandez, Luis G.; Villarreal, David H.; Norwood, Scott] Univ Texas Tyler, Hlth Sci Ctr, Tyler, TX 75799 USA.
   [Fernandez, Luis G.; Villarreal, David H.; Norwood, Scott] Univ Texas Arlington, Arlington, TX 76019 USA.
   [Matthews, Marc R.] Maricopa Cty Gen Hosp, Arizona Burn Ctr, Phoenix, AZ USA.
   [Ellman, Cynthia; Jackson, Patricia] Christus Trinity Mother Frances Hosp, Tyler, TX USA.
C3 University of Texas System; University of Texas at Tyler; University of
   Texas-Health Sciences Center at Tyler (UTHSCT); University of Texas
   System; University of Texas Arlington; Maricopa County General Hospital
RP Fernández, LG (通讯作者)，Univ Texas Hlth East Texas Phys Tyler Trauma Surg, Dept Surg, 1020 E Idel St, Tyler, TX 75701 USA.
EM thebigkahuna115@gmail.com
RI FERNANDEZ, LUIS/O-7657-2019
CR Blalock L, 2019, WOUNDS, V31, P55
   Fernandez L, 2017, Journal of Trauma & Treatment, V06, DOI [10.4172/2167-1222.1000410, 10.4172/2167-1222.1000410, DOI 10.4172/2167-1222.1000410]
   Gupta S, 2017, WOUNDS, pS19
   Kim Paul J, 2015, Surg Technol Int, V26, P51
   Kim PJ, 2015, Wounds, V27, pS2
   KUCHARZEWSKI M, 2014, BIOMED RES INT, V2014
   McElroy EF, 2019, INT WOUND J, V16, P781, DOI 10.1111/iwj.13097
   Panayi AC, 2017, World Journal of Dermatology, V6, P1, DOI [10.5314/wjd.v6.i1.1, 10.5314/wjd.v6.i1.1, DOI 10.5314/WJD.V6.I1.1]
   Schultz GS, 2003, WOUND REPAIR REGEN, V11, pS1, DOI 10.1046/j.1524-475X.11.s2.1.x
   Snyder RJ, 2016, ADV SKIN WOUND CARE, V29, P205, DOI 10.1097/01.ASW.0000482354.01988.b4
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
   Wolvos Tom, 2004, Ostomy Wound Manage, V50, P56
NR 12
TC 13
Z9 15
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2020
VL 32
IS 10
BP 279
EP 282
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QA6PX
UT WOS:000613566600003
PM 33370246
DA 2026-07-24
ER
PT J
AU Xia, ZG
   Wang, CH
   Arnold, A
   Song, JH
   Tang, YZ
   Xu, QL
   Fang, LS
AF Xia, Zhengguo
   Wang, Chunhua
   Arnold, Ashley
   Song, Junhui
   Tang, Yizhong
   Xu, Qinglian
   Fang, Linsen
TI Efficacy of Treating Chronic Tibial Osteomyelitis With Bone Defect Using
   a Pedicled Perforator-Layered Flap and Fasciocutaneous Flap of the
   Posterior Tibial Artery: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE osteomyelitis; bone defect; negative pressure wound therapy; layered
   flap; tissue flap
AB Introduction. Tibial osteomyelitis is a common complication of bone tissue trauma. Obtaining good soft tissue coverage and effective infection management is key to the treatment of chronic osteomyelitis of the tibia accompanied with bone defect and bone exposure. The pedicled posterior tibial artery perforator layered fasciocutaneous flap can be used to repair soft tissue defects and can be used as a long-term, localized anti-infective. Case Report. A 54-year-old male presented with an ulcer, purulent discharge at the left anterior tibia, and a fever 28 years after complete healing of the scar site. The patient received debridement and negative pressure wound therapy (NPWT) in a hospital setting. After presenting to the authors' department, there was difficulty in closing the exposed bone marrow cavity. On the basis of systemic use of intravenous antibiotics, multiple debridements and NPWT were used to effectively remove necrotic tissue and control infection. Afterward, the pedicled posterior tibial artery perforator layered fasciocutaneous flap was designed to fill the bone marrow cavity as well as cover and seal the wound of bone exposure and soft tissue defect simultaneously. The layered fasciocutaneous flap was well established after operation, and no recurrence of osteomyelitis was found. Conclusion. Debridement with negative pressure wound therapy can be an effective treatment for the wound bed preparation in advance of surgery, and the pedicled posterior tibial artery perforator layered fasciocutaneous flap can be used for the treatment of several soft tissue defects.
C1 [Xia, Zhengguo; Fang, Linsen] Anhui Med Univ, Affiliated Hosp 4, Hefei, Anhui, Peoples R China.
   [Wang, Chunhua; Arnold, Ashley; Song, Junhui; Tang, Yizhong; Xu, Qinglian] Anhui Med Univ, Affiliated Hosp 1, Hefei, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Fang, LS (通讯作者)，Anhui Med Univ, Affiliated Hosp 4, Dept Wound Repair Plast & Aesthet Surg, 100 Huaihai Rd, Hefei 230000, Anhui, Peoples R China.
EM shaoshangke@126.com
RI Xia, Zhengguo/JOK-2035-2023
OI Xia, Zhengguo/0000-0002-1912-8966
CR Acartürk TO, 2016, J FOOT ANKLE SURG, V55, P362, DOI 10.1053/j.jfas.2014.12.020
   Bekara F, 2018, MICROSURG, V38, P109, DOI 10.1002/micr.30047
   Buono P, 2018, WORLD J PLAST SURG, V7, P294, DOI 10.29252/wjps.7.3.294
   Chen SL, 2001, CHIN J ORTHOP, V11, P655
   Du Quanhong, 2014, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V28, P562
   El-Sabbagh AH, 2018, CHIN J TRAUMATOL, V21, P197, DOI 10.1016/j.cjtee.2017.08.009
   del Pozo EG, 2018, BMC INFECT DIS, V18, DOI 10.1186/s12879-018-3550-6
   Ju JH, 2018, J ORTHOP SURG RES, V13, DOI 10.1186/s13018-018-0824-z
   [邝艺臻 Kuang Yizhen], 2017, [中国临床解剖学杂志, Chinese Journal of Clinical Anatomy], V35, P252
   Lee KJ, 2016, J PLAST RECONSTR AES, V69, pE229, DOI 10.1016/j.bjps.2016.08.019
   Li JF, 2019, MED SCI MONITOR, V25, P5343, DOI 10.12659/MSM.915921
   Lin CZ, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000009834
   Liu H, 2006, J LIQ CHROMATOGR R T, V29, P15, DOI 10.1080/10826070500358209
   [唐举玉 Tang Juyu], 2020, [中华显微外科杂志, Chinese Journal of Microsurgery], V43, P326
   Wei ZR, 2014, ANN PLAS SURG, V73, P325, DOI 10.1097/SAP.0b013e31827a3007
   Wong JKF, 2017, J PLAST RECONSTR AES, V70, P67, DOI 10.1016/j.bjps.2016.09.028
   Xu Qinglian, 2017, Wounds, V29, pE92
   Yang L, 2020, Zhonghua Shao Shang Za Zhi, V36, P730, DOI 10.3760/cma.j.cn501120-20190621-00281
   [于大志 Yu Dazhi], 2015, [中华显微外科杂志, Chinese Journal of Microsurgery], V38, P372
   Zhao Feng-Lin, 2013, Zhonghua Zheng Xing Wai Ke Za Zhi, V29, P261
NR 20
TC 4
Z9 4
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2020
VL 32
IS 11
BP E50
EP E54
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QA6UA
UT WOS:000613577300001
PM 33465040
DA 2026-07-24
ER
PT J
AU Inukai, K
   Usui, A
   Yamada, M
   Amano, K
   Mukai, N
   Tsunetoshi, Y
   Nakata, Y
   Yokota, J
AF Inukai, Koichi
   Usui, Akihiro
   Yamada, Motohiko
   Amano, Koji
   Mukai, Nobutaka
   Tsunetoshi, Yusuke
   Nakata, Yasuki
   Yokota, Junichiro
TI Open abdominal management for perforative peritonitis with septic shock:
   a retrospective analysis on usefulness of a standardized treatment
   protocol
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Damage control surgery; Open abdominal management; Perforative
   peritonitis; Secondary peritonitis; Septic shock
ID SEVERE SEPSIS; OPEN ABDOMEN; INJURY; TRAUMA
AB Background Damage control surgery (DCS) with open abdominal management (OAM) has been increasingly expanded to include critically ill non-trauma patients. However, there is limited data regarding the usefulness of this protocol for the treatment of severe perforative peritonitis (PP), especially with septic shock (SS). Here, we retrospectively evaluated the usefulness of our OAM protocol for PP with SS. Methods We retrospectively reviewed patients with from June 2015 to September 2018. The proposed protocol was composed of the following steps: (1) rapid control of contamination; (2) temporary abdominal closure; (3) repeated washout of the abdominal cavity; and (4) delayed definitive surgery. For temporary abdominal closure, a negative pressure wound therapy device was used. The end points were the morbidity and 30-day mortality rates. Logistic backward regression was performed to identify factors associated with complications. Results The mortality rate was 4% (1/25) and the overall morbidity rate of surviving patients was 58.3% (14/24). The mean duration of the first DCS was 67.36 +/- 22.83 min. The median durations of ventilation and intensive care unit stay were 5 and 7 days, respectively. Although not significant, morbidity might be associated with age, diabetes mellitus, initial operative time, and OAM duration. Conclusions A standardized protocol for OAM may improve the outcomes of patients with SS due to PP. This damage control approach can be applied for the treatment of severe abdominal sepsis.
C1 [Inukai, Koichi; Usui, Akihiro; Yamada, Motohiko; Amano, Koji; Mukai, Nobutaka; Tsunetoshi, Yusuke; Nakata, Yasuki; Yokota, Junichiro] Sakai City Med Ctr, Dept Acute Care Surg, Nishi Ku, 1-1-1 Ebaraji Cho, Sakai, Osaka 5938304, Japan.
RP Inukai, K (通讯作者)，Sakai City Med Ctr, Dept Acute Care Surg, Nishi Ku, 1-1-1 Ebaraji Cho, Sakai, Osaka 5938304, Japan.
EM koichi.sums@gmail.com; a.usui0126@gmail.com; mt1001vv@kjc.biglobe.ne.jp;
   amanyoppy@yahoo.co.jp; surf-nob@wb4.so-net.ne.jp; ytsunetoshi@gmail.com;
   nakata-ya@sakai-hospital.jp; yokota-j@sakai-hospital.jp
RI Inukai, Koichi/KYQ-8809-2024
CR APRAHAMIAN C, 1990, J TRAUMA, V30, P719, DOI 10.1097/00005373-199006000-00011
   Baothman A, 2016, International Surgery Journal, P746, DOI [10.18203/2349-2902.isj20160658, 10.18203/2349-2902.isj20160658, DOI 10.18203/2349-2902.ISJ20160658]
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NR 29
TC 4
Z9 7
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD FEB
PY 2021
VL 47
IS 1
SI SI
BP 93
EP 98
DI 10.1007/s00068-019-01132-2
PG 6
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA QA9JI
UT WOS:000613758600012
PM 30949740
DA 2026-07-24
ER
PT J
AU Yang, H
   Liu, L
   Li, G
   Chen, YC
   Jiang, D
   Wang, W
   Wang, TY
   Sun, JS
   Che, JF
   Gu, DM
   Lu, M
   Wang, AP
AF Yang, Hui
   Liu, Lan
   Li, Gai
   Chen, Yinchen
   Jiang, Dong
   Wang, Wei
   Wang, Tianyuan
   Sun, Jinshan
   Che, Jianfang
   Gu, Dongmei
   Lu, Meng
   Wang, Aiping
TI Growth Promoting Effect of Vacuum Sealing Drainage in the Healing
   Processes of Diabetic Foot Ulcers
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE vacuum sealing drainage; diabetic foot ulcers; wound healing; CD34;
   CD68; VEGF
ID PRESSURE WOUND THERAPY; TUMOR-CELLS; ACTIVATION
AB Aim: To explore the growth-promoting effect of vacuum sealing drainage (VSD) during the healing processes of diabetic foot ulcers (DFUs).
   Methods: From November 2018 to December 2019, 38 patients with unilateral DFUs were enrolled in this retrospective study. All patients were divided into two groups according to the use of VSD or not: the VSD group (n=20) and the control group (n=18). The following parameters were used to evaluate the healing process: changes in the mean areas of the ulcers; healing rate (HR); epithelial hyperplasia and angiogenesis as determined by hematoxylin-eosin staining (HE staining); and expression of CD34, CD68 and VEGF as assessed through immunohistochemistry. Perioperative side effects and complications were also recorded.
   Results: All patients received follow-up and eventually healed. The mean area of wounds was reduced in the VSD group compared to the control group (1.75 +/- 0.64 cm(2) vs 0.88 +/- 0.54 cm(2), P=0.031). The mean HR of the ulcers in the VSD group was significantly higher than that in the control group (35.23 +/- 2.87% vs 28.78 +/- 1.09%, P=0.017). HE staining showed that the amount of epithelial hyperplasia and angiogenesis increased significantly after VSD, and the immunohistochemistry results showed that the expression of CD34, CD68 and VEGF increased significantly in the VSD group.
   Conclusion: VSD could significantly accelerate the wound healing process, probably by enhancing the inflammatory response and promoting granulation and angiogenesis in DFUs.
C1 [Yang, Hui; Liu, Lan; Li, Gai; Chen, Yinchen; Jiang, Dong; Wang, Wei; Wang, Tianyuan; Sun, Jinshan; Che, Jianfang; Gu, Dongmei; Lu, Meng; Wang, Aiping] Air Force Hosp Eastern Theater PLA, Dept Endocrinol, 1 Malujie Rd, Nanjing 210029, Peoples R China.
RP Lu, M; Wang, AP (通讯作者)，Air Force Hosp Eastern Theater PLA, Dept Endocrinol, 1 Malujie Rd, Nanjing 210029, Peoples R China.
EM lumeng365@hotmail.com; wap454hospital@163.com
RI Wang, Tianyuan/HCH-3483-2022; Aiping, Wang/Y-5737-2018
FU National Natural Science Foundation of China [81770810]; PLA 454
   hospital [10Z014]
FX This work was supported by research-funded projects of PLA 454 hospital
   (10Z014) and the National Natural Science Foundation of China (NO.
   81770810). And the authors gratefully acknowledge the contribution of
   the participants in this study and their families. Hui Yang and Lan Liu
   are co-first authors in this study.
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NR 26
TC 14
Z9 17
U1 0
U2 19
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2021
VL 17
BP 65
EP 71
DI 10.2147/TCRM.S282840
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA QB1TK
UT WOS:000613925500001
PM 33500621
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Huang, JJ
   Ren, HJ
   Jiang, YG
   Wu, XW
   Ren, JN
AF Huang, Jinjian
   Ren, Huajian
   Jiang, Yungang
   Wu, Xiuwen
   Ren, Jianan
TI Technique Advances in Enteroatmospheric Fistula Isolation After Open
   Abdomen: A Review and Outlook
SO FRONTIERS IN SURGERY
LA English
DT Review
DE open abdomen; enteroatmospheric fistula; fistula isolation; biomedical
   device; 3D printing
AB Enteroatmospheric fistula (EAF) after open abdomen adds difficulties to the management and increases the morbidity and mortality of patients. As an effective measurement, reconstructing gastrointestinal tract integrity not only reduces digestive juice wasting and wound contamination, but also allows expedient restoration of enteral nutrition and intestinal homeostasis. In this review, we introduce several technologies for the temporary isolation of EAF, including negative pressure wound therapy, fistuloclysis, fistula patch, surgical covered stent, three-dimensional (3D) printing stent, and injection molding stent. The manufacture and implantation procedures of each technique with their pros and cons are described in detail. Moreover, the approach in combination with finger measurement, x-ray imaging, and computerized tomography is used to measure anatomic parameters of fistula and design appropriate 3D printer-recognizable stereolithography files for production of isolation devices. Given the active roles that engineers playing in the technology development, we call on the cooperation between clinicians and engineers and the organization of clinical trials on these techniques.
C1 [Huang, Jinjian; Ren, Huajian; Jiang, Yungang; Wu, Xiuwen; Ren, Jianan] Southeast Univ, Sch Med, Jinling Hosp, Res Inst Gen Surg, Nanjing, Peoples R China.
C3 Southeast University - China
RP Wu, XW; Ren, JN (通讯作者)，Southeast Univ, Sch Med, Jinling Hosp, Res Inst Gen Surg, Nanjing, Peoples R China.
EM lygwxw@163.com; jiananr@gmail.com
OI Wu, Xiuwen/0000-0002-3813-3867; Huang, Jinjian/0000-0002-8951-8935
FU National Major Scientific and Technological Special Project for
   Significant New Drugs Development [2018ZX09J18111-04]; General Project
   of Military Logistics Research [CLB19J025]; Innovation Project of
   Military Medicine [16CXZ007]; Distinguished Scholars Foundation of
   Jiangsu Province [JCRCB2016006]; Postgraduate Research & Practice
   Innovation Program of Jiangsu Province [KYCX20_0150]
FX We thank to Yanhan Ren in Rosalind Franklin University of Medicine and
   Science, USA for his help in language editing. We also appreciate the
   financial supports from the National Major Scientific and Technological
   Special Project for Significant New Drugs Development
   (2018ZX09J18111-04), General Project of Military Logistics Research
   (CLB19J025), Innovation Project of Military Medicine (16CXZ007),
   Distinguished Scholars Foundation of Jiangsu Province (JCRCB2016006),
   and Postgraduate Research & Practice Innovation Program of Jiangsu
   Province (KYCX20_0150).
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NR 48
TC 10
Z9 19
U1 1
U2 34
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JAN 20
PY 2021
VL 7
AR 559443
DI 10.3389/fsurg.2020.559443
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QB4DM
UT WOS:000614090900001
PM 33553237
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gu, X
   Chen, W
   Yuan, K
   Tan, J
   Sun, SG
AF Gu, Xiang
   Chen, Wei
   Yuan, Kun
   Tan, Jian
   Sun, Suguang
TI The efficacy of artificial dermis combined with continuous vacuum
   sealing drainage in deep neck multiple spaces infection treatment
SO MEDICINE
LA English
DT Article
DE efficacies analysis; multiple spaces infection; the neck abscess; vacuum
   sealing drainage
ID ANTIBIOTIC-SENSITIVITY; MICROBIOLOGY; HEAD; ABSCESSES
AB Deep neck abscesses are dangerous. Artificial dermis combined with seal negative pressure drainage is a new technique for treating refractory wounds. To compare the efficacy of vacuum sealing drainage (VSD) with that of traditional incision drainage approaches for treating deep neck multiple spaces infections. This retrospective analysis includes patient data from our hospital collected from January 2010 to March 2020. A total of 20 cases were identified. Based on the treatment methods, the patients were divided into the VSD group and the traditional group. Inflammation indicators (white blood count, WBC), duration of antibiotic use, hospitalization time, doctors' workload (frequency of dressing changes) and treatment cost were analyzed and compared between the two groups. Of the 20 patients, 11 patients underwent treatment with VSD, while the other 9 underwent traditional treatment. All patients were cured after treatment. Compared with the traditional group, the VSD group had a slower decline in the inflammation index, shorter duration of antibiotic use, shorter hospital stay, and lower doctor workloads (P < .001). There was no significant difference in treatment cost between the two groups (P > .05). VSD technology can markedly improve the therapeutic effect of deep neck multiple spaces infection. This treatment method can be used to rapidly control infections and is valuable in the clinic (P > .05).
C1 [Gu, Xiang; Chen, Wei; Yuan, Kun; Tan, Jian; Sun, Suguang] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Otolaryngol Head & Neck Surg, 26 Shengli St, Wuhan 430000, Peoples R China.
C3 Huazhong University of Science & Technology
RP Sun, SG (通讯作者)，Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Otolaryngol Head & Neck Surg, 26 Shengli St, Wuhan 430000, Peoples R China.
EM 250971686@qq.com
FU Hubei Special Fund for Knowledge Innovation [2017CFB558]
FX This research is funded by Hubei Special Fund for Knowledge Innovation.
   Project number: 2017CFB558.
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NR 20
TC 11
Z9 15
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 5
PY 2021
VL 100
IS 5
AR e24367
DI 10.1097/MD.0000000000024367
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QB6GS
UT WOS:000614237200071
PM 33592884
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jo, T
   Hur, J
   Kim, EK
AF Jo, Taehee
   Hur, Joon
   Kim, Eun Key
TI Treatment of Pediatric Sternotomy Wound Complications: A Minimally
   Invasive Approach
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE wound healing; wound infection; surgery; complications; sternum
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; STERNAL WOUNDS;
   THERAPY
AB Background Pediatric sternal wound complications (SWCs) include sterile wound dehiscence (SWD) and superficial/deep sternal wound infections (SSWI/DSWI), and are generally managed by repetitive debridement and surgical wound approximation. Here, we report a novel nonsurgical management strategy of pediatric sternotomy wound complications, using serial noninvasive wound approximation technique combined with single-use negative pressure wound therapy (PICO) device.
   Methods Nine children with SWCs were managed by serial approximation with adhesive skin tapes and serial PICO device application. Thorough surgical debridement or surgical approximations were not performed.
   Results Three patients were clinically diagnosed as SWD, two patients as SSWI, and four patients as DSWI. None of the wounds demonstrated apparent mediastinitis or bone destructions. PICO device was applied at 16.1 days (range: 6-26 days) postoperatively, together with serial wound approximation by skin tapes. The average duration of PICO use was 16.9 days (range: 11-29 days) and the wound approximation was achieved in all patients. None of the patients underwent aggressive surgical debridement or invasive surgical approximation by sutures.
   Conclusion We report our successful management of selected pediatric SWCs, using serial noninvasive wound approximation technique combined with PICO device.
C1 [Jo, Taehee] Keimyung Univ, Dongsan Med Ctr, Dept Plast & Reconstruct Surg, Sch Med, Daegu, South Korea.
   [Hur, Joon; Kim, Eun Key] Univ Ulsan, Asan Med Ctr, Dept Plast Surg, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
C3 Keimyung University; University of Ulsan; Asan Medical Center
RP Kim, EK (通讯作者)，Univ Ulsan, Asan Med Ctr, Dept Plast Surg, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
EM nicekek@korea.com
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 17
TC 3
Z9 3
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD JAN
PY 2022
VL 70
IS 01
BP 56
EP 64
DI 10.1055/s-0040-1722733
EA FEB 2021
PG 9
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA YW0TU
UT WOS:000614613800004
PM 33540426
DA 2026-07-24
ER
PT J
AU Guerreschi, P
   Casanova, D
   Maunoury, F
   Sinna, R
   Revol, M
AF Guerreschi, P.
   Casanova, D.
   Maunoury, F.
   Sinna, R.
   Revol, M.
TI ALGINATE versus negative-pressure therapy: Comparison of the clinical
   effectiveness, tolerance and costs in management of patients after
   surgical excision. Multicenter, randomized non-inferiority clinical
   trial on 113 patients
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Calcium alginate dressing; Negative Pressure Wound Therapy; Skin
   excision; Cost of patient care
AB Introduction. - Pure calcium alginate dressing (ALGINATE) and Negative Pressure Wound Therapy (NPWT) are frequently used for the preparation of skin excisions for a split thickness skin graft take. The trial compared the healing efficacy, safety and cost of patient care for these two treatments.
   Patients and methods. - This randomized, non-inferiority trial enrolled 113 patients who underwent skin excision (> 30 cm(2)) and received ALGINATE or NPWT. The primary outcome was the time to obtain optimal granulation tissue for a split thickness skin graft take. Secondary outcomes were the occurrence of adverse events (AEs) and the impact of the patient care cost on the Social Security budget.
   Results. - The mean time to optimal granulation was similar between ALGINATE and NPWT: approximately 20 days. No AE was reported with ALGINATE while 24 % of patients treated with NPWT presented an AE. Following hospitalization, 94 % of ALGINATE patients were cared for at home by a private nurse, while 90 % of NPWT patients were followed up in aftercare and rehabilitation facilities or home hospitalization. Therefore, the cost of treatment per patient for the French Social Security was 498 (sic) with ALGINATE and 2104 (sic) with NPWT.
   Conclusion. - This trial has demonstrated that ALGINATE has a similar healing efficacy to that of NPWT, and that it is markedly better with regard to patient safety and cost savings. ALGINATE should therefore be preferred to NPWT in this indication. (C) 2020 Elsevier Masson SAS. All rights reserved.
C1 [Guerreschi, P.] CHRU Lille, Dept Chirurg Plast Esthet & Reconstructrice, 2 Ave Oscar Lambret, F-59000 Lille, France.
   [Casanova, D.] Hop Conception, Dept Chirurg Plast & Reconstructrice, 147 Blvd Baille, F-13005 Marseille, France.
   [Maunoury, F.] STATESIA, 19 Rue Gougeard, F-72530 Yvre Leveque, France.
   [Sinna, R.] CHU Amiens Picardie, Dept Chirurg Plast Esthet & Reconstructrice, 1 Rue Prof Christian Cabrol, F-80054 Amiens, France.
   [Revol, M.] Univ Paris, UFR Villemin, F-75010 Paris, France.
C3 Universite de Lille; CHU Lille; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Universite de Picardie Jules Verne
   (UPJV); CHU Amiens; Universite Paris Cite
RP Revol, M (通讯作者)，Univ Paris, UFR Villemin, F-75010 Paris, France.
EM mrevol05@gmail.com
RI P, Guerreschi/H-4757-2015
CR Ameli fr, 2020, NOMENCLATURE GEN ACT
   Ameli fr, 2020, LISTE PRODUITS PREST
   Andre J., 1997, Revue de l'adphso, V22, P69
   [Anonymous], 2016, PROFESSIONNELS SEDA
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   Casanova D, 2020, PLAST RECONSTR SURG
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NR 35
TC 1
Z9 1
U1 0
U2 4
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
EI 1768-319X
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD FEB
PY 2021
VL 66
IS 1
BP 3
EP 9
DI 10.1016/j.anplas.2020.11.001
EA FEB 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QD1HP
UT WOS:000615278900003
PM 33279277
DA 2026-07-24
ER
PT J
AU Bobkiewicz, A
   Krokowicz, L
   Banasiewicz, T
   Borejsza-Wysocki, M
AF Bobkiewicz, Adam
   Krokowicz, Lukasz
   Banasiewicz, Tomasz
   Borejsza-Wysocki, Maciej
TI Endoscopic vacuum therapy with instillation (iEVT) - a novel endoscopic
   concept for colorectal anastomotic leak and perianal complications
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Article
DE anastomotic leakage; anal fistula; endoscopic vacuum therapy; negative
   pressure wound therapy
ID PRESSURE WOUND THERAPY; ASSISTED CLOSURE; FOAM
AB Introduction: Anastomotic leaks remain the most fearful complications.
   Aim: We present a novel endoscopic salvage therapy known as endoscopic vacuum therapy with instillation (iEVT) as a combination of standard endoscopic vacuum therapy (EVT) and negative pressure wound therapy with instillation (iNPWT).
   Material and methods: A case series of 6 consecutive patients treated with iEVT is presented. A Redon drain and a central venous catheter were introduced within polyurethane foam used as a self-made device for iEVT and anti-microbial solution was instilled.
   Results: A total of 6 patients with the mean age of 29.5 +/- 8.9 were treated with iEVT. The mean number of iEVT sessions was 5.8 +/- 2.3. The mean time of iEVT management was 20.7 +/- 8.8 days. Locally, a reduction in purulent discharge and defect's dimension with contraction were revealed confirmed with imaging studies.
   Conclusions: iEVT is a very encouraging, novel method for complicated perianal diseases and anastomotic leak.
C1 [Bobkiewicz, Adam; Krokowicz, Lukasz; Banasiewicz, Tomasz; Borejsza-Wysocki, Maciej] Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, 49 Przybyszewskiego St, PL-60355 Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Bobkiewicz, A (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, 49 Przybyszewskiego St, PL-60355 Poznan, Poland.
EM bobofon007@gmail.com
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   Fleischmann W, 1998, UNFALLCHIRURG, V101, P649, DOI 10.1007/s001130050318
   Goss SG, 2014, J AM COLL CLIN WOUND, V4, P74, DOI DOI 10.1016/J.JCCW.2014.02.001
   Khan AA, 2008, COLORECTAL DIS, V10, P587, DOI 10.1111/j.1463-1318.2007.01417.x
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NR 15
TC 11
Z9 13
U1 0
U2 2
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2020
VL 15
IS 4
BP 560
EP 566
DI 10.5114/wiitm.2020.93204
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QD6LA
UT WOS:000615625900005
PM 33294070
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Panko, S
   Vakulich, D
   Karpitski, A
   Zhurbenka, H
   Shestiuk, A
   Boufalik, R
   Ihnatsiuk, A
AF Panko, Siarhei
   Vakulich, Denis
   Karpitski, Aliaksandr
   Zhurbenka, Henadzi
   Shestiuk, Andrej
   Boufalik, Rostislav
   Ihnatsiuk, Aliaksandr
TI Intrathoracic negative pressure therapy and/or endobronchial valve for
   pleural empyema minimal invasive management: case series of thirteen
   patients and review of the literature
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Review
DE bronchopleural fistula; video-assisted thoracoscopic surgery; empyema;
   intrathoracic negative pressure therapy; endobronchial valve
ID VACUUM-ASSISTED CLOSURE
AB Introduction: Intrathoracic negative pressure therapy is an adjunct to standard methods of complex empyema management in debilitated patients. Nevertheless, the use of endoscopic one-way endobronchial valves to successfully close large bronchopleural fistulas in patients with advanced pleural empyema has been described in only a few case reports.
   Aim: To present our experience in managing complex pleural empyema using thoracostomy with intrathoracic negative pressure therapy and/or endobronchial valve implantation.
   Material and methods: We retrospectively analyzed data from 13 consecutive patients (11 men, mean age: 56 years, range: 38-80 years) who were treated for pleural empyema using thoracostomy with intrathoracic negative pressure therapy and/or endobronchial valve implantation between October 2015 and November 2017.
   Results: The control of empyema was satisfactory in 12 patients; however, 1 patient died from sepsis-related multi-organ failure despite complete cessation of air leak on day 9 after endobronchial valve implantation. The overall success rate for the final closure of the chest wall was 9/12 patients (75%): in 5 patients, the wall closed spontaneously, and in 4, the wall was closed using thoracomyoplasty.
   Conclusions: Thoracostomy with intrathoracic negative pressure therapy, endobronchial valve implantation with tube drainage, and a combination of the two could adequately manage patients with pleural empyema with or without a persistent air leakage fistula.
C1 [Panko, Siarhei] Jan Kochanowski Univ Humanities & Sci, Fac Hlth Sci, Al 9 Wiekow Kielc 19, Kielce, Poland.
   [Vakulich, Denis; Karpitski, Aliaksandr; Zhurbenka, Henadzi; Boufalik, Rostislav; Ihnatsiuk, Aliaksandr] Brest Reg Hosp, Dept Thorac Surg, Brest, BELARUS.
   [Shestiuk, Andrej] Brest State Univ, Dept Anat & Physiol, Brest, BELARUS.
C3 Jan Kochanowski University; A.S. Pushkin Brest State University
RP Panko, S (通讯作者)，Jan Kochanowski Univ Humanities & Sci, Fac Hlth Sci, Al 9 Wiekow Kielc 19, Kielce, Poland.
EM sppankam@gmail.com
RI ; Panko, Siarhei/AAD-1639-2020
OI Vakulich, DZIANIS/0000-0003-3451-2437; Panko,
   Siarhei/0000-0001-8665-2832
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NR 21
TC 3
Z9 4
U1 0
U2 2
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2020
VL 15
IS 4
BP 588
EP 595
DI 10.5114/wiitm.2020.93210
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QD6LA
UT WOS:000615625900009
PM 33294074
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fowler, AL
   Barry, MK
AF Fowler, Amy Lee
   Barry, Michael Kevin
TI Closed incision negative pressure therapy: Results of recent trials and
   recommendations for clinical practice
SO SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND
   IRELAND
LA English
DT Article
DE Negative pressure wound therapy; Closed incisio; Laparotomy; Open
   abdominal surgery; Surgical site infection; Postoperative complication
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; WOUND THERAPY;
   LAPAROTOMY INCISIONS; PREVENTION; MANAGEMENT; SYSTEM; IMPACT
AB Background: Open abdominal surgery is associated with high rates of wound complications Surgical site infection (SSI) is associated with prolonged length of stay, delayed treatment and high rates of readmission((1, 3, 4)). Negative pressure wound therapy over closed in- cisions (ciNPWT) is a novel approach to prevention of SSI. We reviewed the outcomes of studies comparing ciNPWT and standard therapy in open abdominal wounds to assess the efficacy of the current evidence base.
   Aim: To assess the effect of negative pressure wound therapy used over closed incisions in open abdominal surgery.
   Methods: Search of relevant terms was conducted on PubMed, Scopus and Cochrane to identify studies published between Jan 2006-Feb 2019. Studies were chosen based on specific inclusion criteria. Articles were screened to assess demographics, study design and outcomes.
   Results: Seven retrospective and six prospective randomised controlled trials were identified for inclusion, totalling 3048 participants. 967 received ciNPWT and 2081 received standard treatment. Studies assessed a mix of surgeries (colorectal n = 6, pancreaticoduodenectomy n = 1, gynaecologic n = 1, acute care surgery n = 1, mixed open n = 2). ciNPWT was statistically significant in reducing SSI in 9 of 13 studies.
   Conclusion: ciNPWT in open abdominal surgery has demonstrated promising results for reducing SSI rate in some trials however, patient selection remains unclear. Recent randomized controlled trials have failed to demonstrate benefit overall with use of ciNPWT in open abdominal surgery. Further multicentre prospective trials are needed for cost-benefit analysis and appropriate patient-selection. (C) 2019 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.
C1 [Fowler, Amy Lee; Barry, Michael Kevin] Natl Univ Ireland, Discipline Surg, Galway, Ireland.
   [Fowler, Amy Lee; Barry, Michael Kevin] Royal Coll Surgeons Ireland, Dept Surg Affairs, 121-122 St Stephens Green, Dublin 2, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Royal College of Surgeons in
   Ireland - RCSI
RP Barry, MK (通讯作者)，Natl Univ Ireland, Discipline Surg, Galway, Ireland.
EM kbarsurg@gmail.com
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NR 47
TC 12
Z9 12
U1 0
U2 1
PU ROYAL COLLEGE SURGEONS EDINBURGH
PI EDINBURGH
PA NICOLSON ST, EDINBURGH EH8 9DW, SCOTLAND
SN 1479-666X
EI 2405-5840
J9 SURG-J R COLL SURG E
JI Surg. J. R. Coll. Surg. Edinb. Irel.
PD AUG
PY 2020
VL 18
IS 4
BP 241
EP 250
DI 10.1016/j.surge.2019.10.007
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QE0MR
UT WOS:000615902300009
PM 31822387
DA 2026-07-24
ER
PT J
AU Wöhler, A
   Schwab, R
   Güsgen, C
   Schaaf, S
   Weitzel, C
   Jänig, C
   Willms, A
AF Woehler, Aliona
   Schwab, Robert
   Guesgen, Christoph
   Schaaf, Sebastian
   Weitzel, Carolin
   Jaenig, Christoph
   Willms, Arnulf
TI Diagnosis and Treatment of Severe Fournier's Gangrene: Introduction of a
   Surgical Approach, Evaluation of Risk Factors, Microbiological
   Characteristics and Review of the Literature
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Review
DE Fournier&#700; s gangrene; Fournier&#700; s Gangrene Severity Index
   (FGSI); mortality; surgery
AB Zusammenfassung
   Hintergrund Die Fournier-Gangran ist eine nekrotisierende Fasziitis Typ I der genitalen und perinealen Regionen, die insbesondere bei schweren Verlaufen und systemischer Sepsis mit einer hohen Letalitat vergesellschaftet ist. Der Schwerpunkt wurde auf die Evaluation der Risikofaktoren und Komorbiditaten, auf das bakteriologische Spektrum, laborchemische Analysen, Mortalitat und den Verlauf nach dem algorithmischen Vorgehen gelegt.
   Material und Methoden Es wurden 10 Patienten am Bundeswehrzentralkrankenhaus Koblenz im Zeitraum von 2010 bis 2019 mit einer Fournier-Gangran und Sepsis sowie einer mindestens 48-stundigen Intensivtherapie erfasst und deskriptiv analysiert.
   Ergebnisse Die Patientenkohorte bestand aus 6 mannlichen und 4 weiblichen Patienten mit einem Durchschnittsalter von 62 Jahren (Range 42-78 Jahre). Der durchschnittliche Zeitpunkt zwischen Auftreten der Beschwerden und der Krankenhausaufnahme betrug 4 Tage (Range 3-5). Die haufigste Genese war ein Bagatelltrauma bei bestehender entgleister Diabeteserkrankung (30%). Diabetes mellitus (60%) und Adipositas (80% mit BMI>25) waren fuhrende Risikofaktoren. Bei 90% der Patienten bestand eine polymikrobielle Besiedlung. Alle Patienten wiesen eine Multiorgandysfunktion auf und hatten einen SOFA-Score zwischen 3 und 17 Punkten. Die Mortalitatsrate betrug in unserem Patientenkollektiv 40%. Signifikante Unterschiede zwischen uberlebenden und verstorbenen Patienten zeigten PCT, INR und aPTT (p<0,05).
   Schlussfolgerung Die Fournier-Gangran ist insbesondere bei septischem Verlauf nach wie vor eine Erkrankung mit hoher Letalitatsrate. Bei foudroyantem Verlauf bedarf es einer unmittelbaren Diagnosestellung sowie eines aggressiven operativen Vorgehens, um die Letalitat so gering wie moglich zu halten. Nach initialem radikalem Debridement sowie stabilisierenden intensivmedizinischen Ma<ss>nahmen folgen weitere operative Eingriffe. In der postakuten Phase hat sich die Anwendung der Vakuumtherapie zur Defektverkleinerung bewahrt.
   Abstract
   Background Fourniers gangrene is a necrotising fasciitis type I occurring in the perineal and genital region. The disease expands progressively and still has poor outcome, especially in critical ill patients. This studys focus was placed on the evaluation of risk factors and comorbidities, on the bacteriological spectrum, laboratory analyses, mortality and the course according to the algorithmic approach.
   Method The medical records were reviewed of 10 patients with severe Fourniers gangrene from 2010 to 2019 who underwent intensive care therapy for at least 48 hours. Ten patients with Fourniers gangrene and sepsis and intensive therapy lasting at least 48 hours were recorded and analysed descriptively.
   Results The patient cohort consisted of six men and four women with a median age of 62 years (range 42-78 years). The median time between the onset of symptoms and hospitalisation was four days (range 3-5 days). The commonest aetiological event was a minor trauma. Predisposing factors included diabetes mellitus (30%) and overweight (80% BMI>25). 90% of patients exhibited polymicrobial infection. All patients had systemic sepsis with SOFA-Score between 3 and 17 points. The mortality rate was 40%. Significant differences between surviving and deceased patients were shown by PCT, INR and aPTT (p<0.05).
   Conclusion Severe Fourniers gangrene continues to be a major challenge with a high mortality rate. Only rapid diagnosis, urgent extensive surgical debridement and intensive care therapy can lead to a favourable outcome in these critically ill patients. Vacuum-assisted closure can be successfully used in the management of soft-tissue defects.
C1 [Woehler, Aliona; Schwab, Robert; Guesgen, Christoph; Schaaf, Sebastian; Weitzel, Carolin; Willms, Arnulf] Bundeswehrzentralkrankenhaus Koblenz, Klin Allgemein Viszeral & Thoraxchirurg, Rubenacher Str 170, D-56064 Koblenz, Germany.
   [Jaenig, Christoph] Bundeswehrzentralkrankenhaus Koblenz, Klin Anasthesie Intensivmed & Notfallmed, Koblenz, Germany.
RP Willms, A (通讯作者)，Bundeswehrzentralkrankenhaus Koblenz, Klin Allgemein Viszeral & Thoraxchirurg, Rubenacher Str 170, D-56064 Koblenz, Germany.
EM ArnulfWillms@gmx.de
RI ; /AFN-0812-2022
OI Aliona, Woehler/0000-0002-0225-5950; 
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NR 51
TC 1
Z9 2
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD OCT
PY 2022
VL 147
IS 05
BP 480
EP 491
DI 10.1055/a-1319-1734
EA FEB 2021
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5E7WH
UT WOS:000615971500003
PM 33556981
DA 2026-07-24
ER
PT J
AU Bertoglio, CL
   Morini, L
   Barone, G
   Girardi, V
   Bozzo, S
   Ferrari, G
AF Bertoglio, Camillo Leonardo
   Morini, Lorenzo
   Barone, Gisella
   Girardi, Valerio
   Bozzo, Samantha
   Ferrari, Giovanni
TI Synchronous Surgical Treatment of Morbid Obesity and Complex Ventral
   Hernia After Progressive Pneumoperitoneum and Botulinum Toxin A
   Injection
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Complex ventral hernia; Progressive pneumoperitoneum; Botulin toxin A
AB Introduction The worldwide increase in morbidly obese patients with complex hernia raises controversies in the choice of the appropriate treatment timing: synchronous bariatric and abdominal wall surgery versus delayed abdominal wall surgery. We report an innovative tailored surgical treatment carried out at our Institution. Patient and Methods The approach provided the injection, 6 weeks before surgery, of 500 IU of botulinum toxin A on either side of the large abdominal wall muscles. Four weeks before surgery, pneumoperitoneum was inducted and out-patient daily sessions of progressive insufflation with ambient air were then carried out. Surgery was scheduled 48 days after botulinum injection. Sleeve gastrectomy and simultaneous posterior component separation with transversus abdominis release were performed. Two prosthetic meshes were placed sublay. Postoperative superficial surgical site infection was successfully treated with negative pressure wound therapy. At a 1-year follow-up, no hernia recurrence was recorded while total body weight loss was 31%. Discussion A delay in ventral hernia repair could worsen the quality of life of morbidly obese patients. In such high-risk patients, the choice of the best surgical strategy remains controversial. There is great concern in performing bariatric surgery simultaneously to hernia repair, although there is lack of evidence on which is the ideal treatment modality. Conclusion Synchronous bariatric surgery and complex ventral hernia repair should be approached in high-volume centres where a consolidated experience of multidisciplinary teamwork is available. Combined botulinum toxin A and preoperative progressive pneumoperitoneum administration allow for a safe resolution of loss of domain.
C1 [Bertoglio, Camillo Leonardo; Morini, Lorenzo; Barone, Gisella; Girardi, Valerio; Bozzo, Samantha; Ferrari, Giovanni] ASST Grande Osped Metropolitano Niguarda, Niguarda Gen Hosp, Div Oncol & Minimally Invas Surg, Piazza Osped Maggiore 3, I-20162 Milan, Italy.
RP Bertoglio, CL (通讯作者)，ASST Grande Osped Metropolitano Niguarda, Niguarda Gen Hosp, Div Oncol & Minimally Invas Surg, Piazza Osped Maggiore 3, I-20162 Milan, Italy.
EM camilloleonardo.bertoglio@ospdealeniguarda.it
RI ; Bertoglio, Camillo Leonardo/K-8111-2017; /AAK-1893-2020
OI Morini, Lorenzo/0000-0001-5191-0045; Girardi,
   Valerio/0000-0001-6436-8208; Barone, Gisella/0000-0001-8473-1107; bozzo,
   samantha/0000-0002-4351-4947; Bertoglio, Camillo
   Leonardo/0000-0002-5925-983X; 
CR García-Ureña MA, 2019, WORLD J SURG, V43, P149, DOI 10.1007/s00268-018-4765-9
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NR 15
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD DEC
PY 2021
VL 83
IS 6
BP 1552
EP 1556
DI 10.1007/s12262-021-02764-8
EA FEB 2021
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XM9CU
UT WOS:000616165300002
DA 2026-07-24
ER
PT J
AU Fu, SQ
   Panayi, A
   Fan, JC
   Mayer, HF
   Daya, M
   Khouri, RK
   Gurtner, GC
   Ogawa, R
   Orgill, DP
AF Fu, Siqi
   Panayi, Adriana
   Fan, Jincai
   Mayer, Horacio F.
   Daya, Mahendra
   Khouri, Roger K.
   Gurtner, Geoffrey C.
   Ogawa, Rei
   Orgill, Dennis P.
TI Mechanotransduction in Wound Healing: From the Cellular and Molecular
   Level to the Clinic
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE adipocytes; fibroblasts; keratinocytes; mechanical forces;
   mechanotransduction; negative-pressure wound therapy; scar; skin taping;
   tissue expander; wound healing
AB Skin provides a critical protective barrier for humans that is often lost following burns, trauma, or resection. Traditionally, skin loss is treated with transfer of tissue from other areas of the body such as a skin graft or flap. Mechanical forces can provide powerful alternatives and adjuncts for skin replacement and scar modulation. This article first provides an overview of the various mechanical forces that affect fibroblasts, keratinocytes, endothelial cells, and adipocytes at the cellular and molecular level. This is followed by a review of the mechanical devices currently in clinical use that can substantially augment the restoration of skin integrity and reduce scarring. Methods described include tissue expanders, external volume expansion, negative-pressure wound therapy, and skin taping.
C1 [Fu, Siqi] Second Ziangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China.
   [Panayi, Adriana] Harvard Med Sch, Boston, MA 02115 USA.
   [Fan, Jincai] Peking Union Med Coll, Plast Surg Hosp, Beijing, Peoples R China.
   [Mayer, Horacio F.] Univ Buenos Aires, Plast Surg Dept, Hosp Italian Buenos Aires, Sch Med, Buenos Aires, DF, Argentina.
   [Mayer, Horacio F.] Hosp Italiano Buenos Aires Univ Inst, Buenos Aires, DF, Argentina.
   [Daya, Mahendra] Univ Kwazulu, Nelson R Mandela Sch Med, Dept Plast & Reconstruct Surg, Natal, South Africa.
   [Khouri, Roger K.] Miami Breast Ctr, Key Biscayne, FL USA.
   [Gurtner, Geoffrey C.] Stanford Univ, Dept Surg, Sch Med, Surg,Div Plast & Reconstruct Surg, Stanford, CA USA.
   [Ogawa, Rei] Nippon Med Coll Hosp, Dept Plast Reconstruct & Aesthet Surg, Tokyo, Japan.
   [Orgill, Dennis P.] Harvard Med Sch, Surg, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Plastic Surgery Hospital -
   CAMS; Peking Union Medical College; University of Buenos Aires; Hospital
   Italiano de Buenos Aires; University of Kwazulu Natal; Stanford
   University; Nippon Medical School; Harvard University; Harvard Medical
   School
RP Fu, SQ (通讯作者)，Second Ziangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China.
RI Mayer, Horacio F/AAE-4645-2020; Khouri, Roger/I-2799-2019; Orgill,
   Dennis/H-7596-2019; Panayi, Adriana/HHT-0513-2022
OI Mayer, Horacio F/0000-0002-3586-8657; Khouri, Roger/0000-0002-1848-3149;
   Daya, Mahena/0000-0002-1309-7126; Panayi, Adriana/0000-0003-4053-9855
FU Acelity
FX The authors thank The Gillian Reny Stepping Strong Center for Trauma
   Innovation for the generous donation to the Tissue Engineering and Wound
   Healing Laboratory that helped accomplish this work. Dr Orgill has
   disclosed that he is a consultant to and recipient of grant research
   funding from Acelity, but that his spouse/life partner (if any) has no
   financial relationships with, or financial interests in, any commercial
   organizations relevant to this educational activity. Lippincott CME
   Institute and Lippincott Professional Development have identified and
   resolved all conflicts of interest concerning this educational activity.
   The remaining authors, faculty, staff, and planners, including
   spouses/partners (if any), in any position to control the content of
   this CME/NCPD activity have disclosed that they have no financial
   relationships with, or financial interests in, any commercial companies
   relevant to this educational activity. To earn CME credit, you must read
   the CME article and complete the quiz online, answering at least 7 of
   the 10 questions correctly. This continuing educational activity will
   expire for physicians on January 31, 2023, and for nurses December 2,
   2022. All tests are now online only; take the test at http://cme.lww.com
   for physicians and www.NursingCenter.com/CE/ASWC for nurses. Complete
   NCPD/CME information is on the last page of this article.
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NR 57
TC 22
Z9 30
U1 2
U2 33
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD FEB
PY 2021
VL 34
IS 2
BP 67
EP 74
DI 10.1097/01.ASW.0000725220.92976.a7
PG 8
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA QE8XK
UT WOS:000616488200008
PM 33443911
DA 2026-07-24
ER
PT J
AU Svensson-Björk, R
   Saha, S
   Acosta, S
   Gerdtham, UG
   Hasselmann, J
   Asciutto, G
   Zarrouk, M
AF Svensson-Bjork, Robert
   Saha, Sanjib
   Acosta, Stefan
   Gerdtham, Ulf-G
   Hasselmann, Julien
   Asciutto, Giuseppe
   Zarrouk, Moncef
TI Cost-effectiveness analysis of negative pressure wound therapy dressings
   after open inguinal vascular surgery - The randomised INVIPS-Trial
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Negative pressure wound therapy; Cost-effectiveness analysis;
   Prevention; Surgical site infection; Vascular surgery
ID SURGICAL SITE INFECTIONS; COMPLICATIONS; STANDARD; IMPACT
AB Aim: While the scientific evidence in favour of negative pressure wound therapy (NPWT) dressings on sutured incisions in the prevention of surgical site infections (SSIs) has increased, the cost-effectiveness after vascular surgery has not been evaluated. The aim of this study was to evaluate the cost-effectiveness of NPWT compared to standard dressings for the prevention of SSIs after open inguinal vascular surgery.
   Materials and methods: Patient data were retrieved from the randomised INVIPS-trial's open arm, which included patients randomised to either NPWT or standard dressings. The patients were surveyed for SSIs for 90 days postoperatively. The patients' individual cost data were included and analysed from a healthcare perspective. The patients' quality of life was measured using the Vascuqol-6 questionnaire pre- and 30 days postoperatively. Cost-effectiveness of NPWT was determined by decreased or equal total costs and a significant reduction in SSI incidence. Results: The mean vascular procedure-related costs at 90 days were (sic)16,621 for patients treated with NPWT (n = 59) and (sic)16,285 for patients treated with standard dressings (n = 60), p = 0.85. The SSI incidence in patients treated with NPWT was 11.9% (n = 7/59) compared to 30.0% (n = 18/60) with standard dressings, p = 0.015. This corresponds to an increased mean cost of (sic)1,853 per SSI avoided. The cost-effectiveness plane of incremental vascular procedure-related costs and difference in Vascuqol-6 score showed that 42% of estimates were in the quadrant where NPWT was dominant. Conclusion: NPWT is considered cost-effective over standard dressings in patients undergoing open inguinal vascular surgery due to reduced SSI incidence at no higher costs.
C1 [Svensson-Bjork, Robert; Acosta, Stefan; Hasselmann, Julien; Zarrouk, Moncef] Skane Univ Hosp, Vasc Ctr, Malmo, Sweden.
   [Svensson-Bjork, Robert; Acosta, Stefan; Hasselmann, Julien; Asciutto, Giuseppe; Zarrouk, Moncef] Lund Univ, Dept Clin Sci, Vasc Dis Res Unit, Malmo, Sweden.
   [Saha, Sanjib; Gerdtham, Ulf-G] Lund Univ, Dept Clin Sci, Hlth Econ Unit, Malmo, Sweden.
   [Gerdtham, Ulf-G] Lund Univ, Dept Econ, Lund, Sweden.
   [Asciutto, Giuseppe] Univ Hosp Muenster, Dept Vasc & Endovasc Surg, Munster, Germany.
C3 Lund University; Skane University Hospital; Lund University; Lund
   University; Lund University; University of Munster
RP Svensson-Björk, R (通讯作者)，Ruth Lundskogs Gata 10, S-20502 Malmo, Sweden.
EM Robert.Svensson_Bjork@med.lu.se
RI Hasselmann, Julien/C-1586-2015; Acosta, Stefan/JAX-3225-2023; Gerdtham,
   Ulf-Göran/I-6766-2018; Hasselmann, Julien/C-1586-2015
OI Acosta, Stefan/0000-0002-3225-0798; Gerdtham,
   Ulf-Göran/0000-0002-0647-7817; Hasselmann, Julien/0000-0003-4453-0292;
   Saha, Sanjib/0000-0001-8649-0773
FU Swedish Medical Research Council [2019-00435]; Skane University
   Hospital; Government Grant for Clinical Research (ALF); Region Skane;
   Swedish Research Council [2019-00435] Funding Source: Swedish Research
   Council
FX This study was made possible by unconditional grants from the Swedish
   Medical Research Council (Diary number 2019-00435) and Skane University
   Hospital. The Health Economics Program at Lund University also receives
   unconditional core funding from Government Grant for Clinical Research
   (ALF) and Region Skane (Gerdtham). The funding sources had no influence
   on any part of this study. The authors declare no conflict of interest.
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NR 29
TC 15
Z9 15
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2021
VL 30
IS 1
BP 95
EP 101
DI 10.1016/j.jtv.2020.09.005
EA FEB 2021
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA QF2ER
UT WOS:000616712700014
PM 33046345
OA hybrid
DA 2026-07-24
ER
PT J
AU Liu, XW
   Zhao, Y
   Zhao, FC
   Guo, SL
   Sun, DJ
AF Liu, Xiwen
   Zhao, Yue
   Zhao, Fucheng
   Guo, Suli
   Sun, Daju
TI Surgical treatment of carotid artery stent infection: a case report
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Carotid artery stent infection; vascular graft infection; autologous
   saphenous vein graft revascularization; negative-pressure wound therapy;
   debridement; antibiotic therapy; treatment efficacy
AB The most effective treatment for graft infection is still debated, and the success rate of current treatments is low. We herein report the results of surgical treatment and follow-up of a case of infection acquired during carotid stenting with the aim of exploring the most effective treatments for graft infection. We retrospectively analyzed a patient who was admitted in September 2019. This patient underwent debridement, autologous saphenous vein replacement of the common carotid to internal carotid artery, external carotid artery suturing, and continuous negative-pressure wound therapy for carotid stent infection. Ten days after carotid artery revascularization, the growth of granulation tissue in the incision was good, and we decided to suture the neck incision. Five days after removing the stitches, grade A healing was noted. Furthermore, the carotid artery and autologous vein grafts were unobstructed as shown by carotid artery computed tomography angiography reexamination. The patient was monitored for 8 months with no new neurological symptoms and good healing of the incision. Effective treatment of vascular graft infection includes debridement and removal of the infected graft, autologous vein graft revascularization, and negative-pressure wound therapy combined with antibiotic therapy.
C1 [Liu, Xiwen; Zhao, Yue; Zhao, Fucheng; Guo, Suli; Sun, Daju] Jilin Univ, China Japan Union Hosp, Dept Vasc Surg, 126 Xiantai St, Changchun 130033, Peoples R China.
C3 Jilin University
RP Zhao, Y (通讯作者)，Jilin Univ, China Japan Union Hosp, Dept Vasc Surg, 126 Xiantai St, Changchun 130033, Peoples R China.
EM Z_Yue@jlu.edu.cn
OI Liu, Xiwen/0000-0002-5220-8132
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NR 11
TC 0
Z9 0
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD FEB
PY 2021
VL 49
IS 2
AR 0300060520987081
DI 10.1177/0300060520987081
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA QG5NW
UT WOS:000617632800001
PM 33557657
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Elce, YA
   Ruzickova, P
   da Silveira, EA
   Laverty, S
AF Elce, Y. A.
   Ruzickova, P.
   da Silveira, E. Almeida
   Laverty, S.
TI Use of negative pressure wound therapy in three horses with open,
   infected olecranon bursitis
SO EQUINE VETERINARY EDUCATION
LA English
DT Article
DE horse; negative pressure wound therapy; olecranon bursitis; infection;
   granulation tissue
AB This article describes the clinical use of negative pressure wound therapy (NPWT) in three horses with an open and infected subcutaneous olecranon bursa, in which prior surgical excision followed by primary closure was unsuccessful. The wounds filled in rapidly with granulation tissue and contracted during therapy. All wounds subsequently went on to heal without complications. The use of NPWT was well tolerated in all three horses and facilitated healing in a difficult area.
C1 [Elce, Y. A.; Ruzickova, P.; da Silveira, E. Almeida; Laverty, S.] Univ Montreal, Equine Hosp, Coll Vet Med, St Hyacinthe, PQ, Canada.
   [Elce, Y. A.] Langford Vets, Equine Hosp, Langford House, Bristol, Avon, England.
C3 Universite de Montreal
RP Elce, YA (通讯作者)，Univ Montreal, Equine Hosp, Coll Vet Med, St Hyacinthe, PQ, Canada.; Elce, YA (通讯作者)，Langford Vets, Equine Hosp, Langford House, Bristol, Avon, England.
EM Yvonne.elce@bristol.ac.uk
RI Elce, Yvonne/AAC-9376-2021
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NR 22
TC 6
Z9 9
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0957-7734
EI 2042-3292
J9 EQUINE VET EDUC
JI Equine Vet. Educ.
PD JAN
PY 2020
VL 32
IS 1
BP 12
EP 17
DI 10.1111/eve.12930
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA QH8NV
UT WOS:000618529900004
DA 2026-07-24
ER
PT J
AU Kirsner, RS
   Hurd, T
AF Kirsner, Robert S.
   Hurd, Theresa
TI Assessing the Need for Negative Pressure Wound Therapy Utilization
   Guidelines: An Overview of the Challenges With Providing Optimal Care
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE negative pressure wound therapy; single-use negative pressure wound
   therapy; wound management; quality of life; operational efficiencies;
   financial efficiencies
ID COST-MINIMIZATION ANALYSIS; EXPERIENCES; IMPACT; DEVICE; NPWT
AB Negative pressure wound therapy (NPWT) has evolved beyond its original design as a stationary, reusable system (traditional NPWT [tNPWT]) and is now also available as a single-use, portable device (sNPWT). No established guidance exists for selecting the appropriate system to treat specific wound types in various settings. This article reviews the current practice and challenges associated with NPWT. Relevant literature was reviewed to provide a background on current practice. An online quantitative survey was performed during October and November 2018 among users of NPWT based in acute care settings across 6 countries (Australia, France, Germany, Italy, the United Kingdom, and the United States) to elucidate the operational and financial components considered in determining and/or thwarting efficacious use of NPWT. Data from recruited participants were collected, analyzed, and tabulated by an independent research company. All findings were reported as numbers/percentages. Wound size and depth, as well as the amount and/or type of exudate, were found to be among key factors in selecting NPWT; patient quality of life in terms of mobility, independence, and attitude toward treatment may be factors in adherence with prescribed care. Clinicians were not consistently knowledgeable about the financial and operational challenges of utilization presented by large fleets of NPWT pumps, nor were other institutional employees such as payers and discharge planners. Evidence-based recommendations are needed to guide decisions regarding NPWT systems, which in turn may improve therapy implementation, access to care, and patient quality of life, while driving operational and financial efficiencies for health care providers.
C1 [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Hosp & Clin Wound Ctr, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
   [Hurd, Theresa] Nursing Practice Solut, Stevensville, ON, Canada.
   [Hurd, Theresa] Catholic Hlth, Buffalo, NY USA.
C3 University of Miami
RP Kirsner, RS (通讯作者)，Univ Miami, Dept Dermatol & Cutaneous Surg, Sch Med, 1600 NW 10th Ave,RMSB 2023A, Miami, FL 33136 USA.
EM RKirsner@med.miami.edu
CR Adeyemi A, 2018, WOUNDS, V30, pE13
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NR 42
TC 11
Z9 11
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2020
VL 32
IS 12
BP 328
EP 333
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QI0SU
UT WOS:000618686200001
PM 33472158
DA 2026-07-24
ER
PT J
AU Joo, HS
   Lee, SJ
   Lee, SY
   Sung, KY
AF Joo, Hong Sil
   Lee, Seung Je
   Lee, Sang-Yeul
   Sung, Kun Yong
TI The Efficacy of Negative Pressure Wound Therapy for Split-thickness Skin
   Grafts for Wounds on the Trunk or the Neck: A Randomized Controlled
   Trial
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE split-thickness skin graft; negative pressure wound therapy;
   conventional bolster dressing
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE; RUBBER; TIE
AB Introduction. Because applying a splint for a wound on a patient's trunk or neck (including areas such as the shoulder, chest, buttock, axilla, and abdomen) is considerably difficult, grafted skin may not firmly affix at the wound site. Objective. A study was conducted to compare negative pressure wound therapy (NPWT) to conventional bolster dressings in facilitating firm split-thickness skin graft (STSG) attachment and allowing relatively easy removal of exudates. Materials and Methods. A randomized controlled trial was conducted among 57 patients with wounds on the trunk or the neck who received STSGs between January 2013 and December 2017. Prospective and retrospective data were used for analysis in this study. Patients who were pregnant, immunocompromised, or had severely infected wounds were excluded from the study. Due to discomfort, splints were not used. Patients were divided into 2 groups. Group 1 was provided a NPWT dressing; NPWT was applied continuously for 6 days between -75 mm Hg and -100 mm Hg with dressing changes at postoperative days 3 and 6. After postoperative day 6, antibiotic cream and a nonadherent foam dressing were used on the wounds. Group 2 was provided a conventional bolster dressing for the same time frame. The Mann-Whitney U test was used to compare the variables and outcomes between the 2 groups. Differences were considered statistically significant for P<.05. Results. Among the 57 patients, 27 received NPWT and 30 received the bolster dressing. The size of the wounds in these patients ranged between 100 cm(2) and 400 cm(2). In group 1, the average survival score for the skin graft was more than 80 in all patients after postoperative day 7. In group 2, major graft loss occurred in 5 patients, requiring a second STSG. The average score of STSG survival on postoperative day 7 in group 2 was lower than that of group 1. The differences observed between the 2 groups were overall statistically significant (P < .01) based on the results of the Mann-Whitney U test. Conclusions. Owing to the flexibility and elasticity afforded by the transparent adhesive film that is used in NPWT technique, patients were more mobile and felt little discomfort compared to conventional procedures. The negative pressure dressing increased the percentage of graft survival and may reduce need for a second STSG.
C1 [Joo, Hong Sil; Lee, Seung Je] Hanil Gen Hosp, Dept Plast & Reconstruct Surg, Seoul, South Korea.
   [Lee, Sang-Yeul; Sung, Kun Yong] Kangwon Natl Univ, Chunchon, South Korea.
C3 Kangwon National University
RP Sung, KY (通讯作者)，Kangwon Natl Univ, Med, 1 Kangwondaehak Gil, Chuncheon Si 24341, Kangwondo, South Korea.
EM ps@kangwon.ac.kr
CR [Anonymous], 2017, J WOUND MANAGEMENT R, DOI DOI 10.22467/
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NR 22
TC 3
Z9 4
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2020
VL 32
IS 12
BP 334
EP 338
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QI0SU
UT WOS:000618686200002
PM 33465041
DA 2026-07-24
ER
PT J
AU Davis, KE
   La Fontaine, J
   Farrar, D
   Oz, OK
   Crisologo, PA
   Berriman, S
   Lavery, LA
AF Davis, Kathryn E.
   La Fontaine, Javier
   Farrar, David
   Oz, Orhan K.
   Crisologo, Peter A.
   Berriman, Sandra
   Lavery, Lawrence A.
TI Randomized clinical study to compare negative pressure wound therapy
   with simultaneous saline irrigation and traditional negative pressure
   wound therapy for complex foot infections
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
AB The aim of this study was to compare the efficacy of different negative pressure wound therapy (NPWT) devices and NPWT with and without simultaneous irrigation in patients admitted to hospital with moderate and severe foot infections. Ninety patients were randomized in a 12-week prospective, randomized noninferiority trial to compare wound healing in patients with moderate and severe infected foot wounds treated with NPWT after surgery. Inclusion criteria included ABI > 0.5 or toe pressures >30 PVR/mmHg, >18 years of age and exclusion included active Charcot arthropathy, collagen vascular disease, HIV, and hypercoagulable state. We compared two different traditional devices, NPWT-K (KCI, VAC Ulta) and NPWT-C (Cardinal, PRO), and NPWT-I with saline irrigation (Cardinal, PRO). All patients had therapy delivered at 125 mmHg continuous pressure. In patients who received simultaneous saline irrigation (NPWT-I), the administration rate was 15 ml per hour. The primary outcome was the proportion of healed wounds in 12 weeks. Secondary outcomes included surgical wound closure, number of surgeries, length of stay, and time to wound healing. Continuous data was presented as mean +/- standard deviation. Analysis of variance was used to compare continuous variables and chi-square to compare dichotomous variables with an alpha of 0.05. There were no differences in outcomes among NPWT-I, NPWT-C, and NPWT-K groups in proportion of healed wounds (63.3%, 50.0%, 46.7% p = 0.39), surgical wound closure (83.3%, 80.0%, 63.3%, p = 0.15), number of surgeries (2.0 +/- 0.49, 2.4 +/- 0.77, 2.4 +/- 0.68, p = 0.06), length of stay (16.3 +/- 15.7, 14.7 +/- 7.4, 15.3 +/- 10.5 days, p = 0.87), time to wound healing (46.2 +/- 22.8, 40.9 +/- 18.8, 45.9 +/- 28.3 days, p = 0.78). We did not identify any significant differences in clinical outcomes or adverse events between patients treated with different NPWT devices or NPWT with and without irrigation.
C1 [Davis, Kathryn E.; La Fontaine, Javier; Crisologo, Peter A.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
   [Farrar, David] Univ Texas Southwestern Med Ctr Dallas, Dept Immunol & Mol Biol, Dallas, TX 75390 USA.
   [Oz, Orhan K.] Univ Texas Southwestern Med Ctr Dallas, Dept Radiol, Dallas, TX USA.
   [Berriman, Sandra] Berriman Consulting, Princeton, NJ USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas Southwestern
   Medical Center; University of Texas System; University of Texas
   Southwestern Medical Center
RP Lavery, LA (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM larry.lavery@utsouthwestern.edu
RI Crisologo, Peter/JZE-5379-2024; Oz, Orhan/GVT-7264-2022
OI Crisologo, Peter/0000-0002-5367-9235; Lavery,
   Lawrence/0000-0002-7920-9952; 
FU Cardinal Health, Inc., Dublin, OH, USA
FX This was an investigator-initiated study funded by Cardinal Health,
   Inc., Dublin, OH, USA.
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NR 20
TC 31
Z9 36
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN-FEB
PY 2020
VL 28
IS 1
BP 97
EP 104
DI 10.1111/wrr.12741
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA QI3OM
UT WOS:000618888700011
PM 31245901
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Liu, XL
   Huo, D
   Wu, GZ
AF Liu, Xilin
   Huo, Da
   Wu, Guangzhi
TI Deep Inferior Epigastric Flap Combined Bilateral-Anterolateral Thigh
   Flap for the Coverage of Both Lower Extremity Soft-Tissue Defect: A Case
   Report and a Literature Review
SO CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
LA English
DT Review
DE anterolateral thigh perforator flap; deep inferior epigastric perforator
   flap; soft tissue repair; skin repair
ID PERFORATOR FLAP; RECONSTRUCTION; SCALP
AB Background/Purpose: Anterolateral thigh perforator (ALTP) flap and deep inferior epigastric perforator (DIEP) flap have been advantageous over traditional myocutaneous flaps as they preserve the integrity of donor site muscles and minimize the damage and complication to donor site structures. Here, we reported the efficacy of free ALTP and DIEP in the repair of large skin area and soft tissue defects on both lower limbs after trauma.
   Case Report: A 19-year-old female traffic accident victim presented with multiple open bilateral fractures to the lower extremities with joint dislocation, massive skin and soft tissue defects, and multiple soft tissue contusion. Wounds on both lower extremities were covered with VSD (Vacuum Sealing Drainage). The tibiofibular and ankle joints on both lower limbs were fixed using external fixators. DIEP and ALTP flap were performed at different times.
   Results: After transfer, the vascular pedicle was anastomosed to the anterior tibial artery, posterior tibial artery, and the accompanying vein. After the operation, the donor site was directly closed and sutured. All flaps survived with a good appearance, leaving only a linear scar at the donor site.
   Conclusion: This case shows that free ALTP and DIEP flaps are ideal for repairing large skin area and soft tissue defects in bilateral lower limbs after trauma.
C1 [Liu, Xilin; Huo, Da; Wu, Guangzhi] Jilin Univ, Dept Hand Surg, China Japan Union Hosp, Changchun 130033, Peoples R China.
C3 Jilin University
RP Wu, GZ (通讯作者)，Jilin Univ, Dept Hand Surg, China Japan Union Hosp, Changchun 130033, Peoples R China.
EM wuguangzhi@jlu.edu.cn
RI Huo, Dacheng/MTF-4009-2025
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NR 19
TC 3
Z9 3
U1 0
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7015
J9 CLIN COSMET INV DERM
JI CLIN. COSMET. INVESTIG. DERMATOL.
PY 2021
VL 14
BP 153
EP 161
DI 10.2147/CCID.S292053
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QI4JS
UT WOS:000618946200001
PM 33603432
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, Q
   Zhang, N
   Li, ZN
   He, HM
AF Liu, Qian
   Zhang, Ning
   Li, Zhengnan
   He, Hongmei
TI Efficacy of autologous platelet-rich plasma gel in the treatment of
   refractory pressure injuries and its effect on wound healing time and
   patient quality of life
SO CLINICS
LA English
DT Article
DE Crush Injuries; Autologous Platelet-Rich Plasma Gel; Wound Healing;
   Quality of Life
ID REJUVENATION; REGENERATION; VALIDATION
AB OBJECTIVES: To evaluate the efficacy of autologous platelet-rich plasma (PRP) gel in the treatment of refractory pressure injuries and its effect on wound healing time and quality of life of patients.
   METHODS: A random number table method was used to group 102 patients with refractory pressure injuries into either a control group (CG) (51 cases) receiving negative pressure wound therapy (NPWT) or a study group (SG) (51 cases) receiving NPVVT + PRP gel.
   RESULTS: The total efficacy rate in the SG (92.16%) was higher than that in the CG (76.47%) (p < 0.05). The SG exhibited lower visual analog scale (VAS) scores and pressure ulcer scale for healing (PUSH) scores, smaller wound sizes and depths, and shorter wound healing times than the CG after 21 days of treatment (p < 0.05). After 6 months of treatment, the SG scored higher than the CG on the psychological, physiological, social functions, and daily activity domains on the World Health Organization Quality of Life (WHOQOL-BREF) scale (p < 0.05). The incidence of postoperative complications in the SG (13.73%) was not significantly different from that of the CG (7.84%) (p > 0.05).
   CONCLUSION: In the treatment of refractory pressure injuries, PRP gel can accelerate wound healing, reduce wound pain, shorten the treatment cycle, regulate tissue inhibitor matrix metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-9 (MMP-9) levels and the expression of specific proteins in granulation tissue, reduce the levels of the inflammatory factors interleukin-1 beta (IL-1 beta), IL-8, and tumor necrosis factor-alpha (TNF-alpha), and improve the quality of life of patients without increasing complications.
C1 [Liu, Qian; Li, Zhengnan] Ganzhou Peoples Hosp, Dept Sports Med, Ganzhou 341000, Jiangxi, Peoples R China.
   [Zhang, Ning; He, Hongmei] Ganzhou Peoples Hosp, Dept Gastroenterol, Ganzhou 341000, Jiangxi, Peoples R China.
RP He, HM (通讯作者)，Ganzhou Peoples Hosp, Dept Gastroenterol, Ganzhou 341000, Jiangxi, Peoples R China.
EM qviyq9@163.com
RI Zhang, Xiaoning/AAD-5635-2020
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NR 25
TC 20
Z9 24
U1 0
U2 20
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PY 2021
VL 76
AR e2355
DI 10.6061/clinics/2021/e2355
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QI5LL
UT WOS:000619018900001
PM 33567047
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Orlov, A
   Gefen, A
AF Orlov, Aleksei
   Gefen, Amit
TI How influential is the stiffness of the foam dressing on soft tissue
   loads in negative pressure wound therapy?
SO MEDICAL ENGINEERING & PHYSICS
LA English
DT Article
DE Wound care; Tissue repair and regeneration; Pressure ulcer; Diabetic
   foot ulcer; Biomechanical model
AB Negative pressure wound therapy (NPWT) is an established adjunctive modality for treatment of both acute and chronic wounds. However, little is known about the optimal settings and combination of treatment parameters and importantly, how these translate to target tissue strains and stresses that would result the fastest healing and buildup of good-quality tissues. Here we have used a three-dimensional open wound computational (finite element) model that contains viscoelastic skin, adipose and skeletal muscle tissue components for determining the states of tissue strains and stresses in and around the wound when subjected to NPWT with foam dressings of varying stiffnesses. We found that the skin strain state is considerably more sensitive to the pressure level than to the stiffness of the foam dressing within a 8.25 to 99 kPa range which covers the current industry standard. Accordingly, pen-wound skin strains and stresses which stimulate cell proliferation/migration and angiogenesis and thereby, healing of the wound, can be more effectively controlled by adjusting the pressure level than by varying the stiffness of the foam dressing. (C) 2021 IPEM. Published by Elsevier Ltd. All rights reserved.
C1 [Orlov, Aleksei; Gefen, Amit] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-6997801 Tel Aviv, Israel.
C3 Tel Aviv University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-6997801 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
FU European Union's Horizon 2020 research and innovation programme under
   the Marie Sklodowska-Curie grant [811965]; Israeli Ministry of Science &
   Technology (Medical Devices Program) [3-17421]
FX This project has received funding from the European Union's Horizon 2020
   research and innovation programme under the Marie Sklodowska-Curie grant
   agreement No. 811965 (STINTS). This work was also partially supported by
   the Israeli Ministry of Science & Technology (Medical Devices Program
   Grant no. 3-17421, awarded to Professor Amit Gefen in 2020).
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NR 43
TC 8
Z9 9
U1 0
U2 15
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1350-4533
EI 1873-4030
J9 MED ENG PHYS
JI Med. Eng. Phys.
PD MAR
PY 2021
VL 89
BP 33
EP 41
DI 10.1016/j.medengphy.2021.02.001
EA FEB 2021
PG 9
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA QI7OJ
UT WOS:000619172500006
PM 33608123
DA 2026-07-24
ER
PT J
AU Campitielio, F
   Mancone, M
   Della Corte, A
   Guerniero, R
   Canonico, S
AF Campitielio, Ferdinando
   Mancone, Manfredi
   Della Corte, Angela
   Guerniero, Raffaella
   Canonico, Silvestro
TI Expanded negative pressure wound therapy in healing diabetic foot
   ulcers: a prospective randomised study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE diabetes; diabetic foot ulcer; dressing; infection; macrostrain;
   microstrain; negative-pressure wound therapy;
   reconstructive-regenerative surgery; ulcer; wound
ID VACUUM-ASSISTED CLOSURE; GENERAL-SURGERY; LAPAROTOMY; MANAGEMENT;
   INCISIONS; DEVICE; TRIAL; DEFORMATIONS; EFFICACY; DISEASE
AB Objective: This study aims to evaluate the benefits of treating diabetic foot ulcers (DFU) through a revised procedure using the mechanisms underlying negative pressure wound therapy (NPWT) in such a way as to achieve reduced and more evenly distributed lateral tension lines across the wound.
   Method: Patients with type 2 diabetes were assessed for elegibility. Included patients were divided randomly into two groups: the NPWT control group and the NPWT+ group. Patients in the NPWT control group were treated in the traditional manner: wounds were covered with foams shaped to fit the wound precisely. In the NPWT+ group, foams were shaped to fit the wound precisely, and an additional foam was then wrapped around the foot.
   Results: Some 85 patients were assessed for eligibility; 59 were randomised into two groups: 29 patients in the NPWT+ group and 30 patients in the NPWT group. The primary objective was median healing time (NPWT+ 19 days, interquartile ratio (IQR) 7.5; NPWT 33 days, IQR 16; p<0.00001), and complete wound healing at three weeks (NPWT+ 55.20%; NPWT 26.70%; p=0.02). Secondary endpoints included number of major amputations (none in either group) and number of infections (NPWT+ 3.44% of patients, NPWT 6.66% of patients; p=0.57).
   Conclusion: Our initial findings show that this treatment significantly reduced wound closure times and accelerated healing in DFUs. It also demonstrated promising improvements in healing rates, with no significant increase in wound complications.
C1 [Campitielio, Ferdinando; Mancone, Manfredi; Della Corte, Angela; Guerniero, Raffaella; Canonico, Silvestro] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Miraglia 2, Naples, Campania, Italy.
C3 Universita della Campania Vanvitelli
RP Mancone, M (通讯作者)，Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Miraglia 2, Naples, Campania, Italy.
EM manconemanfredi@gmail.com
RI MANCONE, MANFREDI/AAQ-7069-2020
OI MANCONE, MANFREDI/0000-0002-6443-5092
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NR 63
TC 24
Z9 25
U1 1
U2 20
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2021
VL 30
IS 2
BP 121
EP 129
DI 10.12968/jowc.2021.30.2.121
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QJ4TC
UT WOS:000619683500006
PM 33573486
DA 2026-07-24
ER
PT J
AU Lehrman, JD
AF Lehrman, Jeffrey D.
TI Combining the Benefits of Collagen and Negative Pressure Wound Therapy
   to Heal a Chronic Diabetic Foot Ulcer: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE diabetic foot ulcer; chronic wound; foot and ankle; negative pressure
   wound therapy; collagen
AB Introduction. Diabetes affects 30 million children and adults in the United States, equivalent to 1 out of every 11 people in the country, and results in costs of $327 billion annually. Interventions that can improve healing rates and/or reduce the size of diabetic ulcers may lower the incidence of infection, rate of amputations, and cost of care. This report is on the use of a collagen wound contact layer in conjunction with negative pressure wound therapy (NPWT) to achieve healing in a chronic diabetic foot ulcer (DFU). Case Report. A known patient with type 1 diabetes presented with a chronic DFU of 6 months' duration. Previous treatment modalities included offloading regimens and topical therapies (ie, clostridial collagenase, human platelet-derived growth factors, and 6 applications of a human amniotic membrane allograft). A collagen wound contact layer was applied to the debrided wound bed with subsequent debridements performed every other week, weekly NPWT dressing changes, and weekly contact layer changes. A 91% reduction in wound area was seen at day 35, with complete healing at day 63, and no recurrence at 18 months. Conclusions. The combination of a collagen wound contact layer and weekly NPWT had a significantly positive effect on healing in this chronic DFU. The regimen was well-tolerated and simple to administer in this case.
C1 [Lehrman, Jeffrey D.] Foot & Ankle Specialists Delaware Cty, Springfield, PA USA.
RP Lehrman, JD (通讯作者)，POB 270968, Ft Collins, CO 80527 USA.
EM jdlehrman@hotmail.com
CR [Anonymous], 2015, IDF Diabetes Atlas, V7
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NR 13
TC 7
Z9 8
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2020
VL 32
IS 3
BP E11
EP E13
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QJ6MA
UT WOS:000619801500001
PM 32335522
DA 2026-07-24
ER
PT J
AU Kwa, KAA
   Krijnen, P
   Bernards, AT
   Schipper, IB
   Meij-de Vries, A
   Breederveld, RS
AF Kwa, Kelly Aranka Ayli
   Krijnen, Pieta
   Bernards, Alexandra T.
   Schipper, Inger B.
   Meij-de Vries, Annebeth
   Breederveld, Roelf S.
TI Bacterial Species and Load Increase During Negative Pressure Wound
   Therapy: A Prospective Cohort Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE bacteria; infection; negative pressure wound therapy; NPWT;
   Staphylococcus aureus
ID VACUUM-ASSISTED CLOSURE; CARE SETTINGS; INFECTIONS; MANAGEMENT; INJURY;
   GROIN
AB Introduction. The course of both the bacterial species and load and the incidence of infection during negative pressure wound therapy (NPWT) are unclear, with published studies presenting contradicting results. Objective. The aim of the study is to assess the changes in both bacterial species and load, as well as the incidence of infection, before and after NPWT in a patient population with a variety of wounds. Methods. Surgical patients 18 years of age or older who needed NPWT were included in this multicenter, prospective cohort study. A wound swab culture was taken before NPWT and either immediately following NPWT or 6 weeks of follow-up. The change of bacterial species, bacterial load, and rate of infection were determined before and after the start of NPWT. Results. In total, 104 patients were analyzed. The number of positive cultures increased from pre- to post-NPWT. The most cultured pathogenic bacterium was Staphylococcus aureus. The bacterial load was moderately higher at the end of NPWT than at the start (P < .0001). It was noted that 2 swabs contained multidrug-resistant bacteria, 1 pre-NPWT and 1 post-NPWT. Prior to NPWT, 26 patients had a wound infection, 5 of which had a persisting infection at the end of the study. Post-NPWT, 14 patients developed a wound infection. Conclusions. The number of S aureus strains and overall bacterial load increased during NPWT, and the incidence of infection remained the same. Further studies should be conducted to determine whether the increase in bacterial load influences other wound outcome parameters.
C1 [Kwa, Kelly Aranka Ayli; Krijnen, Pieta; Schipper, Inger B.; Breederveld, Roelf S.] Leiden Univ, Med Ctr, Dept Trauma Surg, K6-50,POB 9600, NL-2300 RC Leiden, Netherlands.
   [Kwa, Kelly Aranka Ayli; Meij-de Vries, Annebeth; Breederveld, Roelf S.] Red Cross Hosp, Bum Ctr Beverwijk, Beverwijk, Netherlands.
   [Bernards, Alexandra T.] Leiden Univ, Med Ctr, Dept Med Microbiol, Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University;
   Leiden University Medical Center (LUMC)
RP Krijnen, P (通讯作者)，Leiden Univ, Med Ctr, Dept Trauma Surg, K6-50,POB 9600, NL-2300 RC Leiden, Netherlands.
EM p.krijnen@lumc.nl
RI Inger, Schipper/ABE-7796-2021
OI Inger, Schipper/0000-0001-9952-3079; Krijnen, Pieta/0000-0002-7154-9514
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   Thomas S., INTRO USE VACUUM ASS
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   Yusuf E, 2013, WOUND REPAIR REGEN, V21, P677, DOI 10.1111/wrr.12088
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NR 43
TC 6
Z9 7
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2020
VL 32
IS 3
BP 74
EP 80
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QJ6MA
UT WOS:000619801500004
PM 32163041
DA 2026-07-24
ER
PT J
AU Cole, W
AF Cole, Windy
TI Early-stage Management of Complex Lower Extremity Wounds Using Negative
   Pressure Wound Therapy With Instillation and a Reticulated Open Cell
   Foam With Through Holes
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE lower extremity wounds; negative pressure wound therapy with
   instillation and dwell time; NPWTi-d; wound complications; debridement;
   wound cleansing
ID OUTCOMES
AB Introduction. Treatment modalities that overcome stalled wound healing in lower extremity wounds are crucial for reducing lower limb amputations, which have a 5-year mortality rate of an astounding 70%. Recent non-comparative studies have shown negative pressure wound therapy with instillation and dwell time (NPWTi-d) using a dressing comprised of reticulated open cell foam with through holes (ROCF-CC) provides favorable clinical outcomes for various wound types, including complex lower extremity wounds. Objective. The objective of this study is to compare NPWTi-d using ROCF-CC dressings (treatment group) with advanced wound dressings (control group) in patients with chronic lower extremity wounds and known systemic risk factors for delayed healing. Materials and Methods. A retrospective assessment was performed for 10 patients with complex lower extremity wounds that underwent an initial debridement and then were treated with either advanced wound dressings (control group; n = 5) or NPWTi-d using ROCF-CC dressings (treatment group; n = 5). Advanced wound dressings were applied to wounds and changed 1 to 3 times per week. Negative pressure wound therapy with instillation and dwell time was applied by instilling normal saline onto wounds, with a dwell time of 20 minutes, followed by continuous negative pressure (-125 mm Hg) for 2 hours. The ROCF-CC dressings were changed every 2 to 3 days. Results. Patients in the treatment group had significantly fewer wound complications (P = .024) and underwent significantly fewer surgical debridements (P = .004) when compared with patients in the control group. All wounds in the treatment group healed without complication, whereas only 2 of the 5 wounds in the control group healed. Demographics and comorbidities were similar between groups. Conclusions. These data further support the use of NPWTi-d with ROCF-CC to help manage complex wounds of the lower limb.
C1 [Cole, Windy] Kent State Univ, Coll Podiatr Med Wound Care, Independence, OH 44242 USA.
C3 University System of Ohio; Kent State University
RP Cole, W (通讯作者)，Kent State Univ, Coll Podiatr Med Wound Care, Wound Care Res, 6000 Rockside Woods Blvd, Independence, OH 44242 USA.
EM drwec@yahoo.com
CR Blalock L, 2019, WOUNDS, V31, P55
   Cole WE, EPLASTY
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NR 16
TC 3
Z9 3
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2020
VL 32
IS 6
BP 159
EP 163
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QJ6MV
UT WOS:000619803600003
PM 32335516
DA 2026-07-24
ER
PT J
AU Yeung, E
   Kaster, M
   Scheese, D
   Mathews, T
   Prezkop, G
   Golden, D
   Granet, J
   Behm, R
AF Yeung, Enoch
   Kaster, Matthew
   Scheese, Daniel
   Mathews, Trey
   Prezkop, Gabrielle
   Golden, Daniel
   Granet, Jason
   Behm, Robert
TI Closing Contaminated Fascial Defects With Synthetic Mesh and a
   Vacuum-Assisted Closure Device
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Synthetic mesh; VAC dressing; Open abdomen; Fistula
ID ABDOMINAL-WALL DEFECTS; NEGATIVE-PRESSURE; POLYPROPYLENE; REPAIR;
   HERNIA; MANAGEMENT; IMPACT
AB Background: The use of synthetic mesh is considered too high risk, and therefore, not an option when closing a contaminated abdominal fascial defect. This study evaluated the clinical outcomes when using synthetic mesh combined with vacuum-assisted closure (VAC) dressing to close these facial defects.
   Materials and methods: From 2010 to 2016, a retrospective review was performed, including 34 patients in a single rural trauma center who underwent a damage control laparotomy in the presence of a contaminated or infected field. Definitive abdominal closure with a bridging polypropylene mesh along with the application of a VAC dressing was done in all cases. Data collection included baseline demographics, operative indication, postoperative complications, mortality and length of follow up.
   Results: Median age of the patients was 67 y (IQR 40-87 y), with 22 (65%) being male at the time of operation. The median duration of clinical follow-up was 15.15 mo. The observed complications included three fistulas, two hernias, nine draining sinus tracts, and three mesh explanations with an overall complication rate of 41.1%. Although the absolute observed fistula rate was 8.8% (3 cases), the adjusted mesh-related fistulas formation rate after chart review was 0.0%. No mortalities were attributed directly to mesh-related complication.
   Conclusions: This study found no mesh-related fistulas when using a synthetic mesh along with a VAC dressing for abdominal closure in a contaminated field. These results may provide a platform for further study regarding the safety of this technique. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Yeung, Enoch; Kaster, Matthew; Scheese, Daniel; Mathews, Trey; Prezkop, Gabrielle; Golden, Daniel; Granet, Jason; Behm, Robert] Guthrie Robert Packer Hosp, Sayre, PA USA.
RP Behm, R (通讯作者)，Guthrie Clin, 1 Guthrie Sq, Sayre, PA 18840 USA.
EM robert.behm@guthrie.org
RI Scheese, Daniel/JXX-3586-2024
OI Mathews, Trey/0000-0001-6948-8874
CR Bucalo Brian, 1993, Wound Repair and Regeneration, V1, P181, DOI 10.1046/j.1524-475X.1993.10308.x
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NR 21
TC 3
Z9 3
U1 0
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAR
PY 2021
VL 259
BP 313
EP 319
DI 10.1016/j.jss.2020.09.031
EA FEB 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QK3GA
UT WOS:000620267800039
PM 33127065
DA 2026-07-24
ER
PT J
AU Berrevoet, F
   Lampaert, S
   Singh, K
   Jakipbayeva, K
   van Cleven, S
   Vanlander, A
AF Berrevoet, Frederik
   Lampaert, Silvio
   Singh, Kashika
   Jakipbayeva, Kamilya
   van Cleven, Stijn
   Vanlander, Aude
TI Early Initiation of a Standardized Open Abdomen Treatment With Vacuum
   Assisted Mesh-Mediated Fascial Traction Achieves Best Results
SO FRONTIERS IN SURGERY
LA English
DT Article
DE open abdomen; dynamic closure; negative pressure therapy; fascial
   closure; abdominal compartment syndrome; mesh mediated fascial traction
ID PRESSURE WOUND THERAPY; SEPTIC PATIENTS; DELAYED CLOSURE; MANAGEMENT;
   CLASSIFICATION
AB Background: The open abdomen (OA) is an important approach for managing intra-abdominal catastrophes and continues to be the standard of care. Complete fascial closure is an essential treatment objective and can be achieved by the use of different dynamic closure techniques. Both surgical technique and-decision making are essential for optimal patient outcome in terms of fascial closure. The aim of this study was to analyse patients' outcome after the use of mesh-mediated fascial traction (MMFT) associated with negative pressure wound therapy (NPWT) and identify important factors that negatively influenced final fascial closure.
   Methods: A single center ambispective analysis was performed including all patients treated for an open abdomen in a tertiary referral center from 3/2011 till 2/2020. All patients with a minimum survival >24 h after initiation of treatment were analyzed. The data concerning patient management was collected and entered into the Open Abdomen Route of the European Hernia Society (EHS). Patient basic characteristics considering OA indication, primary fascial closure, as well as important features in surgical technique including time after index procedure to start mesh mediated fascial traction, surgical closure techniques and patients' long-term outcomes were analyzed.
   Results: Data were obtained from 152 patients who underwent open abdomen therapy (OAT) in a single center study. Indications for OAT as per-protocol analysis were sepsis (33.3%), abdominal compartment syndrome (31.6%), followed by peritonitis (24.2%), abdominal trauma (8.3%) and burst abdomen (2.4%). Overall fascial closure rate was 80% as in the per-protocol analysis. When patients that started OA management with MMFT and NPWT from the initial surgery a significantly better fascial closure rate was achieved compared to patients that started 3 or more days later (p < 0.001). An incisional hernia developed in 35.8% of patients alive with a median follow-up of 49 months (range 6-96 months).
   Conclusion: Our main findings emphasize the importance of a standardized treatment plan, initiated early on during management of the OA. The use of vacuum assisted closure in combination with MMFT showed high rates of fascial closure. Absence of initial intraperitoneal NPWT as well as delayed start of MMFT were risk factors for non-fascial closure. Initiation of OA with VACM should not be unnecessary delayed.
C1 [Berrevoet, Frederik; Lampaert, Silvio; Singh, Kashika; Jakipbayeva, Kamilya; van Cleven, Stijn; Vanlander, Aude] Ghent Univ Hosp, Dept Gen & Hepatopancreaticobiliary Surg & Liver, Ghent, Belgium.
C3 Ghent University; Ghent University Hospital
RP Berrevoet, F (通讯作者)，Ghent Univ Hosp, Dept Gen & Hepatopancreaticobiliary Surg & Liver, Ghent, Belgium.
EM frederik.berrevoet@ugent.be
RI Vanlander, Aude/AAP-3342-2021; Lampaert, Silvio/HMP-2845-2023;
   Berrevoet, Frederik/A-6117-2008
CR Acosta S, 2017, ANAESTH INTENSIVE TH, V49, P139, DOI 10.5603/AIT.a2017.0023
   Berrevoet F, 2018, FRONT SURG, V5, DOI 10.3389/fsurg.2018.00011
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   Rasilainen SK, 2012, BRIT J SURG, V99, P1725, DOI 10.1002/bjs.8914
   Salamone G, 2018, WORLD J SURG, V42, P1679, DOI 10.1007/s00268-017-4354-3
   Sartelli M, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0032-7
   Tolonen M, 2017, J TRAUMA ACUTE CARE, V82, P1100, DOI 10.1097/TA.0000000000001452
   Truong D, 2009, MANUAL OF BOTULINUM TOXIN THERAPY, P1, DOI 10.1017/CBO9780511575761
   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
   Wang YF, 2019, WORLD J SURG, V43, P3044, DOI 10.1007/s00268-019-05166-w
   Willms A, 2017, HERNIA, V21, P279, DOI 10.1007/s10029-017-1572-4
   Willms A, 2016, HERNIA, V20, P849, DOI 10.1007/s10029-016-1534-2
   Willms A, 2015, LANGENBECK ARCH SURG, V400, P91, DOI 10.1007/s00423-014-1240-4
   Wondberg D, 2008, WORLD J SURG, V32, P2724, DOI 10.1007/s00268-008-9762-y
   Zielinski MD, 2013, HERNIA, V17, P101, DOI 10.1007/s10029-012-0995-1
NR 34
TC 10
Z9 16
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD FEB 9
PY 2021
VL 7
AR 606539
DI 10.3389/fsurg.2020.606539
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QK7JB
UT WOS:000620557300001
PM 33634162
OA Green Accepted, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU de Henau, M
   Kruit, AS
   Ulrich, DJO
AF de Henau, Melissa
   Kruit, Anne Sophie
   Ulrich, Dietmar J. O.
TI Reconstruction of full thickness wounds using glyaderm in a
   single-staged procedure
SO CELL AND TISSUE BANKING
LA English
DT Article
DE Full thickness wound; Dermal substitute; Glyaderm; Skin graft; Negative
   pressure wound therapy
AB Introduction In large full-thickness skin defects, donor site morbidity limits the available thickness and surface of skin autografts and therefore only split-thickness skin grafts are possible for reconstruction. Dermal equivalents can be added to these split-thickness grafts to acquire an anatomically better skin reconstruction. Glyaderm is a human derived, acellular dermis and up until now has only been used in a two-staged procedure. This report describes results of a case series using Glyaderm and split-thickness skin grafts in a single-staged procedure. Methods Glyaderm was introduced in 2017 in Radboudumc (Nijmegen, The Netherlands). Glyaderm and autologous split-skin grafts were simultaneously applied to the wounds. In cases with large wound surfaces or wounds covering highly mobile areas, negative pressure wound therapy was additionally applied. The first ten cases were followed with regular intervals post-operatively, assessing graft take, scar appearance, post-operative wound problems and re-interventions. Results Patients were aged 3 weeks to 76 years-old. Treated skin surface varied from 1-16% total body surface. Wounds resulted from trauma (n = 4), burns (n = 4) or soft tissue infections (n = 2). Follow-up varied from 4 months to 1.5 years. No complications occurred after surgery. Average take rate was 98%. Two patients had a later re-intervention to further improve the aesthetic appearance of the scarred area. Conclusion Our first results with the application of Glyaderm in a single-staged procedure provided good healing, graft take and scar appearance. Glyaderm was found a suitable dermal substitute in the treatment of full thickness wounds.
C1 [de Henau, Melissa; Kruit, Anne Sophie; Ulrich, Dietmar J. O.] Radboud Univ Nijmegen, Med Ctr, Dept Plast & Reconstruct Surg, Geert Grootepl Zuid 10, NL-6523 GA Nijmegen, Netherlands.
C3 Radboud University Nijmegen
RP Kruit, AS (通讯作者)，Radboud Univ Nijmegen, Med Ctr, Dept Plast & Reconstruct Surg, Geert Grootepl Zuid 10, NL-6523 GA Nijmegen, Netherlands.
EM annesophie.kruit@radboudumc.nl
RI Kruit, Anne Sophie/B-4061-2017
OI Kruit, Anne Sophie/0000-0001-6368-9974
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 17
TC 7
Z9 7
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9333
EI 1573-6814
J9 CELL TISSUE BANK
JI Cell Tissue Banking
PD JUN
PY 2021
VL 22
IS 2
SI SI
BP 199
EP 205
DI 10.1007/s10561-021-09907-x
EA FEB 2021
PG 7
WC Cell Biology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA SN3LB
UT WOS:000620867900001
PM 33620693
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Cuomo, R
   Grimaldi, L
   Nisi, G
   Zerini, I
   Giardino, FR
   Brandi, C
AF Cuomo, Roberto
   Grimaldi, Luca
   Nisi, Giuseppe
   Zerini, Irene
   Giardino, Francesco Ruben
   Brandi, Cesare
TI Ultraportable Devices for Negative Pressure Wound Therapy: First
   Comparative Analysis
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Article
DE negative pressure wound therapy; wound care; ultraportable devices;
   PICO; Nanova; SNaP
AB Background: The author proposes to compare ultraportable devices for Negative Pressure Wound Therapy. Main reviews in literature assert that there is a lack in data about this topic. Materials and Methods: The study was conducted in 3 phases. The first phase involved a deep study of all the characteristics and indications of the ultraportable devices for available NPWT, highlighting dimensions, type of canister, functioning, mmHg negative pressure, the modality of use. The second phase was clinical: we treated 125 patients and described our 2 years experience. We treated the first 25 patients with PICO; then, second 25 patients with Nanova, then Uno, VacVia, and Snap in order to obtain 5 group of 25 patients. The third phase of the study consisted in the collection of data of scientific literature on classic and ultraportable devices: other experiences, multicentric studies, case reports, new suggestions, and other data on the topic were analyzed providing a synthesis of all available information. We made a diagram in order to summarize our experience and to compare the devices. Results: We described the main characteristics, main advantages and disadvantages of all devices. The literature data allowed us to investigate better to these aspects and to confirm the lack in comparing ultraportable negative wound pressure devices. Conclusions: All ultraportable devices have singular characteristics. Physician who want to use them, must know them in order to made appropriate therapy.
C1 [Cuomo, Roberto; Grimaldi, Luca; Nisi, Giuseppe; Zerini, Irene; Giardino, Francesco Ruben; Brandi, Cesare] Univ Siena, Santa Maria Alle Scotte Hosp, Unit Plast & Reconstruct Surg, Siena, Italy.
C3 University of Siena
RP Cuomo, R (通讯作者)，Univ Siena, Santa Maria Alle Scotte Hosp, I-53100 Siena, Italy.
EM robertocuomo@outlook.com
RI Cuomo, Roberto/AFI-8757-2022
OI Cuomo, Roberto/0000-0002-8396-095X; Giardino, Francesco
   Ruben/0000-0003-3293-8936
CR [Anonymous], 2014, Prevention and Treatment of Pressure Ulcers: Quick Reference Guide
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NR 36
TC 19
Z9 20
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0894-1939
EI 1521-0553
J9 J INVEST SURG
JI J. Invest. Surg.
PD MAR 16
PY 2021
VL 34
IS 3
BP 335
EP 343
DI 10.1080/08941939.2019.1616009
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QL3ZA
UT WOS:000621016800014
PM 31132881
DA 2026-07-24
ER
PT J
AU Grabinska, A
   Michalczyk, L
   Banaczyk, B
   Syrylo, T
   Zabkowski, T
AF Grabinska, Agnieszka
   Michalczyk, Lukasz
   Banaczyk, Beata
   Syrylo, Tomasz
   Zabkowski, Tomasz
TI Management protocol for Fournier's gangrene in sanitary regime caused by
   SARS-CoV-2 pandemic: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Fournier&#8217; s gangrene; Management; Negative pressure wound therapy;
   Treatment; Orchiectomy; Case report; Necrotic tissues; SARS-CoV-2
AB BACKGROUND
   Fournier's gangrene (FG) is a serious, aggressive and often deadly polymicrobial infection of the soft tissues of the perineum, the rectum and the external genital organs. It is an anatomical subcategory of necrotizing fasciitis, which has a similar etiology and treatment strategy.
   CASE SUMMARY
   A 60-year-old man was admitted to the hospital during severe acute respiratory syndrome coronavirus 2 pandemic with complaints of fever up to 38.9 degrees C, abdominal pain, and edema of the scrotum, the penis, the perineum, and the right gluteal region for 2 d. Computed tomography of the abdomen and the pelvis revealed extensive inflammatory infiltrations of the subcutaneous tissue of the hypogastrium, and the penis; along with liquefaction and presence of gas in the subcutaneous tissues of the scrotum, the perineum, and the right gluteal region. The patient was diagnosed with FG, and was urgently qualified to undergo surgery in the Department of Urology. After performing the necessary examinations, a resection of the necrotic tissues with bilateral orchiectomy and excision of the penile and scrotal skin was performed. After surgery, he was transferred to the intensive care unit for further management.
   CONCLUSION
   Early management prevents the resection of the other organs by inhibiting the contiguous spread of infection.
C1 [Grabinska, Agnieszka; Syrylo, Tomasz; Zabkowski, Tomasz] Mil Inst Med, Dept Urol, 128 Szaserow, PL-04141 Warsaw, Poland.
   [Michalczyk, Lukasz; Banaczyk, Beata] Praski Hosp Warsaw, Dept Urol & Oncol Urol, PL-04141 Warsaw, Poland.
C3 Military Institute of Aviation Medicine
RP Zabkowski, T (通讯作者)，Mil Inst Med, Dept Urol, 128 Szaserow, PL-04141 Warsaw, Poland.
EM urodent@wp.pl
RI Zabkowski, Tomasz/H-8645-2018
CR Bhargav NarendraJ., 2020, WORLD J CURR MED PHA, V2, P191
   Chennamsetty A, 2015, THER ADV UROL, V7, P203, DOI 10.1177/1756287215584740
   Furr J, 2017, UROLOGY, V102, P79, DOI 10.1016/j.urology.2016.09.021
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   Kim SY, 2015, UROLOGY, V85, P1052, DOI 10.1016/j.urology.2014.08.063
   Lauerman MH, 2017, J TRAUMA ACUTE CARE, V83, P443, DOI [10.1097/TA.0000000000001562, 10.1097/ta.0000000000001562]
   Li C, 2015, UROL INT, V94, P453, DOI 10.1159/000366137
   Puvanendran R, 2009, CAN FAM PHYSICIAN, V55, P981
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NR 12
TC 1
Z9 4
U1 0
U2 2
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD FEB 16
PY 2021
VL 9
IS 5
BP 1215
EP 1220
DI 10.12998/wjcc.v9.i5.1215
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QL9SL
UT WOS:000621420500025
PM 33644187
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Shiels, SM
   Sgromolo, NM
   Wenke, JC
AF Shiels, S. M.
   Sgromolo, N. M.
   Wenke, J. C.
TI Negative pressure wound therapy does not diminish efficacy of topical
   antibiotic powder in a preclinical contaminated wound model
SO BONE & JOINT RESEARCH
LA English
DT Article
DE Local antibiotic therapy; Musculoskeletal infection; Topical antibiotic;
   Orthopaedic trauma
ID SURGICAL SITE INFECTIONS; VANCOMYCIN POWDER; OPEN FRACTURES;
   BONE-CEMENT; DELIVERY; BEADS; TRAUMA; DEPOT; RECONSTRUCTION;
   COMPLICATIONS
AB Aims
   High-energy injuries can result in multiple complications, the most prevalent being infection. Vancomycin powder has been used with increasing frequency in orthopaedic trauma given its success in reducing infection following spine surgery. Additionally, large, traumatic injuries require wound coverage and management by dressings such as negative pressure wound therapy (NPWT). NPWT has been shown to decrease the ability of antibiotic cement beads to reduce infection, but its effect on antibiotic powder is not known. The goal of this study was to determine if NPWT reduces the efficacy of topically applied antibiotic powder.
   Methods
   Complex musculoskeletal wounds were created in goats and inoculated with a strain of Staphylococcus aureus modified to emit light. Six hours after contaminating the wounds, imaging, irrigation, and debridement and treatment application were performed. Animals received either vancomycin powder with a wound pouch dressing or vancomycin powder with NPWT.
   Results
   There were no differences in eradication of bacteria when vancomycin powder was used in combination with NPWT (4.5% of baseline) compared to vancomycin powder with a wound pouch dressing (1.7% of baseline) (p = 0.986), even though approximately 50% of the vancomycin was recovered in the NPWT exudate canister.
   Conclusion
   The antimicrobial efficacy of the vancomycin powder was not diminished by the application of NPWT. These topical and locally applied therapies are potentially effective tools that can provide quick, simple treatments to prevent infection while providing coverage. By reducing the occurrence of infection, the recovery is shortened, leading to an overall improvement in quality of life.
C1 [Shiels, S. M.; Sgromolo, N. M.; Wenke, J. C.] US Army Inst Surg Res, Orthopaed Trauma Res Dept, San Antonio, TX 78234 USA.
   [Sgromolo, N. M.] Brooke Army Med Ctr, Dept Orthopaed Surg, San Antonio, TX USA.
C3 United States Department of Defense; United States Army; United States
   Department of Defense; United States Army; Brooke Army Medical Center
RP Shiels, SM (通讯作者)，US Army Inst Surg Res, Orthopaed Trauma Res Dept, San Antonio, TX 78234 USA.
EM stefanie.m.shiels.civ@mail.mil
FU Orthopaedic Trauma Research Department; Veterinary Support Group
FX The authors would like to thank the Orthopaedic Trauma Research
   Department and the Veterinary Support Group for their support.
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NR 55
TC 7
Z9 11
U1 0
U2 3
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2046-3758
J9 BONE JOINT RES
JI Bone Jt. Res.
PD FEB
PY 2021
VL 10
IS 2
BP 149
EP 155
DI 10.1302/2046-3758.102.BJR-2020-0171.R1
PG 7
WC Cell & Tissue Engineering; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Orthopedics
GA QQ1NP
UT WOS:000624293500007
PM 33595334
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Alamdari, NM
   Mehraneroodi, B
   Gholizadeh, B
   Zeinalpour, A
   Safe, P
   Besharat, S
AF Malekpour Alamdari, Nasser
   Mehraneroodi, Behrooz
   Gholizadeh, Barmak
   Zeinalpour, Adel
   Safe, Parima
   Besharat, Sara
TI The efficacy of negative pressure wound therapy compared with
   conventional dressing in treating infected diabetic foot ulcers: a
   randomized controlled trial
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Negative pressure wound therapy; Diabetic foot ulcer; Conventional
   dressing
AB Introduction Despite advances made in diagnosing and controlling diabetes mellitus (DM), treatment of diabetic foot ulcers (DFUs) is still among challenges faced by physicians. Negative pressure wound therapy (NPWT) is one of newer modalities proposed in the treatment of DFUs. However, there is lack of evidence to support its mileage in this regard. This study was conducted with the aim of assessing the efficacy of NPWT in healing process of DFUs. Materials and methods Sixty patients with DM were randomly allocated into two groups consisting of 30 patients each: the intervention group received sub-atmospheric pressure of - 75 to - 100 mmHg (5 min on, 2 min off) with dressings changed every 48 h, and the control group was treated with silver sulfadiazine dressings, changed twice daily. Patients were followed up until complete closure of ulcers, with a mean duration of 3 months. Results Of the total 60 patients, 27 patients (45%) were females. Most of the patients in both groups had DFUs of grade 2 according to Wegner's classification. Rate of healing of the ulcers was significantly higher by using NPWT (p-value 0.01). NPWT also caused a significant reduction in ulcer surface area, depth, size, major and minor amputations, and disability duration (p-values 0.008, 0.002, 0.02, 0.03, and 0.01, respectively). No significant decrease in occurrence of complications was seen with NPWT. Conclusion NPWT seems to be more efficacious than conventional dressing in treating infected DFUs.
C1 [Malekpour Alamdari, Nasser; Gholizadeh, Barmak; Zeinalpour, Adel] Shahid Beheshti Univ Med Sci, Crit Care Qual Improvement Res Ctr, Shahid Modarres Hosp, Dept Gen Surg, Tehran, Iran.
   [Malekpour Alamdari, Nasser; Mehraneroodi, Behrooz; Safe, Parima] Shahid Beheshti Univ Med Sci, Clin Res & Dev Ctr, Shahid Modarres Hosp, Dept Gen Surg, Tehran, Iran.
   [Besharat, Sara] Shahid Beheshti Univ Med Sci, Clin Res & Dev Ctr, Shahid Modarres Hosp, Dept Radiol, Yadegar E Emam Highway, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Besharat, S (通讯作者)，Shahid Beheshti Univ Med Sci, Clin Res & Dev Ctr, Shahid Modarres Hosp, Dept Radiol, Yadegar E Emam Highway, Tehran, Iran.
EM besharat.sara@gmail.com
RI /O-5613-2018; Malekpour Alaari, Nasser/H-9889-2017; /AAY-1095-2020
OI Malekpour Alaari, Nasser/0000-0003-3278-9205; 
CR Alavi A, 2014, J AM ACAD DERMATOL, V70, DOI 10.1016/j.jaad.2013.06.055
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NR 24
TC 16
Z9 18
U1 6
U2 37
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD OCT
PY 2021
VL 41
IS 4
BP 664
EP 668
DI 10.1007/s13410-021-00941-9
EA MAR 2021
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YA9CF
UT WOS:000625823200001
DA 2026-07-24
ER
PT J
AU Wei, S
   Wang, W
   Li, L
   Meng, HY
   Feng, CZ
   Dong, YY
   Fang, XC
   Dong, QQ
   Jiang, W
   Xin, HL
   Li, ZZ
   Wang, X
AF Wei, Shuai
   Wang, Wei
   Li, Li
   Meng, Hao-Ye
   Feng, Chun-Zhen
   Dong, Yu-Ying
   Fang, Xi-Chi
   Dong, Qi-Qiang
   Jiang, Wen
   Xin, Hai-Li
   Li, Zhan-Zhen
   Wang, Xin
TI Recombinant human epidermal growth factor combined with vacuum sealing
   drainage for wound healing in Bama pigs
SO MILITARY MEDICAL RESEARCH
LA English
DT Article
DE Vacuum sealing drainage; Epidermal growth factor; Skin wound healing;
   Full-thickness skin defect
AB Background Vacuum sealing drainage (VSD) and epidermal growth factor (EGF) both play an important role in the treatment of wounds. This study aims to explore the effects of the combination of VSD and EGF on wound healing and the optimal concentration and time of EGF. Methods We tested the proliferation and migration capacity of HaCaT and L929 cells at different EGF concentrations (0, 1, 5, 10, and 100 ng/ml) and different EGF action times (2, 10, and 30 min). A full-thickness skin defect model was established using male, 30-week-old Bama pigs. The experiment included groups as follows: routine dressing change after covering with sterile auxiliary material (Control), continuous negative pressure drainage of the wound (VSD), continuous negative pressure drainage of the wound and injection of EGF 10 min followed by removal by continuous lavage (V + E 10 min), and continuous negative pressure drainage of the wound and injection of EGF 30 min followed by removal by continuous lavage (V + E 30 min). The wound healing rate, histological repair effect and collagen deposition were compared among the four groups. Results An EGF concentration of 10 ng/ml and an action time of 10 min had optimal effects on the proliferation and migration capacities of HaCaT and L929 cells. The drug dispersion effect was better than drug infusion after bolus injection effect, and the contact surface was wider. Compared with other groups, the V + E 10 min group promoted wound healing to the greatest extent and obtained the best histological score. Conclusions A recombinant human epidermal growth factor (rhEGF) concentration of 10 ng/ml can promote the proliferation and migration of epithelial cells and fibroblasts to the greatest extent in vitro. VSD combined with rhEGF kept in place for 10 min and then washed, can promote wound healing better than the other treatments in vivo.
C1 [Wei, Shuai; Meng, Hao-Ye; Wang, Xin] Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Regenerat Med Orthopaed, Inst Orthopaed, Beijing 100583, Peoples R China.
   [Wei, Shuai; Li, Zhan-Zhen; Wang, Xin] Zhoushan Dinghai Guanghua Hosp, Zhoushan 316000, Peoples R China.
   [Wei, Shuai] Tianjin Univ, Tianjin Hosp, Tianjin 300211, Peoples R China.
   [Wang, Wei] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Geriatr Neurol Dept, Beijing 100853, Peoples R China.
   [Wang, Wei] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing 100853, Peoples R China.
   [Li, Li] Tradit Chinese Med Hosp Xinjiang Uygur Autonomous, Dept Orthoped, Urumqi 830000, Peoples R China.
   [Feng, Chun-Zhen] Chinese Peoples Liberat Army Gen Hosp, Dept Stomatol, Beijing 100853, Peoples R China.
   [Dong, Yu-Ying] Taiyuan Iron & Steel Ltd Co, Gen Hosp, Dept Plast Surg, Taiyuan 030009, Peoples R China.
   [Fang, Xi-Chi] Shenzhen Peoples Hosp, Hand Microsurg Dept, Shenzhen 518020, Peoples R China.
   [Dong, Qi-Qiang] Zhengzhou Renji Hosp, Surg Dept 3, Zhengzhou 450000, Peoples R China.
   [Jiang, Wen] Shihezi Univ, Med Coll, Affiliated Hosp 1, Dept Orthoped, Xinjiang 832000, Uygur Autonomou, Peoples R China.
   [Xin, Hai-Li] Chinese Peoples Liberat Army Gen Hosp, Pharm Dept, Beijing 100853, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Tianjin University;
   Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese People's Liberation Army
   General Hospital; Taiyuan Iron & Steel Group; Jinan University; Shihezi
   University; Chinese People's Liberation Army General Hospital
RP Wang, X (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Regenerat Med Orthopaed, Inst Orthopaed, Beijing 100583, Peoples R China.; Li, ZZ; Wang, X (通讯作者)，Zhoushan Dinghai Guanghua Hosp, Zhoushan 316000, Peoples R China.
EM lizz2688@163.com; wangx126@126.com
RI wei, shuai/AAD-7254-2021; WANG, Xinxin/MVW-1205-2025
OI wei, shuai/0000-0002-2435-815X; 
FU National Natural Science Foundation of China [81972047, 81603008,
   81572148]
FX This study was supported in part by the National Natural Science
   Foundation of China (81972047, 81603008, 81572148).
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NR 48
TC 41
Z9 47
U1 3
U2 37
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2095-7467
EI 2054-9369
J9 MILITARY MED RES
JI MILITARY MED. RES.
PD MAR 9
PY 2021
VL 8
IS 1
AR 18
DI 10.1186/s40779-021-00308-5
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QT6BM
UT WOS:000626671200001
PM 33685528
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Poteet, SJ
   Schulz, SA
   Povoski, SP
   Chao, ALH
AF Poteet, Stephen J.
   Schulz, Steven A.
   Povoski, Stephen P.
   Chao, Albert H.
TI Negative pressure wound therapy: device design, indications, and the
   evidence supporting its use
SO EXPERT REVIEW OF MEDICAL DEVICES
LA English
DT Review
DE Negative pressure; negative pressure wound therapy; wounds; wound
   healing
ID VACUUM-ASSISTED CLOSURE; TRIAL; STATE
AB Introduction: Negative pressure wound therapy (NPWT) has become a mainstay in the armamentarium for wound care. Since the initial commercial vacuum-assisted closure device became available in 1995, subsequent research has confirmed the positive physiological effects of negative pressure on wound healing. Traditionally, NPWT has been used to improve healing of open nonsurgical wounds by secondary intention. However, the clinical applications of NPWT have significantly broadened, and now also include use in open surgical wounds, closed surgical incisions, and skin graft surgery. In addition, devices have evolved and now include functionality and features such as instillation, antimicrobial sponges, and portability.
   Areas covered: This article reviews the history, background, and physiology underlying NPWT, as well as the most commonly used devices. In addition, an evidence-based discussion of the current clinical applications of NPWT is presented, with a focus on those with high levels of evidence.
   Expert opinion: Future directions for device development include modifications to increase ease of use by patients and to allow its use in a broader array of anatomic areas. Lastly, more research with high levels of evidence is needed to better define the outcomes associated with NPWT, including in relation to specific clinical applications and cost.
C1 [Poteet, Stephen J.; Schulz, Steven A.; Chao, Albert H.] Ohio State Univ, Dept Plast Surg, 915 Olentangy River Rd, Columbus, OH 43212 USA.
   [Povoski, Stephen P.] Ohio State Univ, Dept Surg, Div Surg Oncol, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Chao, ALH (通讯作者)，Ohio State Univ, Dept Plast Surg, 915 Olentangy River Rd, Columbus, OH 43212 USA.
EM Albert.Chao@osumc.edu
RI Povoski, Stephen/E-3887-2011
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NR 81
TC 24
Z9 31
U1 2
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1743-4440
EI 1745-2422
J9 EXPERT REV MED DEVIC
JI Expert Rev. Med. Devices
PD FEB 1
PY 2021
VL 18
IS 2
BP 151
EP 160
DI 10.1080/17434440.2021.1882301
EA MAR 2021
PG 10
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA RS6AL
UT WOS:000628036800001
PM 33496626
DA 2026-07-24
ER
PT J
AU Wang, J
AF Wang, Jun
TI Reconstructing abdominal wall defects with a free composite tissue flap:
   A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Abdominal wall defect; Anterolateral thigh flap; Repair; Tensor fascia
   lata; Case report
AB BACKGROUND
   Reconstructive repair of huge full-thickness abdominal wall defects following debridement for abdominal electric burns remains a clinically challenging task. An ideal abdominal wall repair means a re-closure of the defected abdominal wall with pedicled neurovascular myofascial flaps, restoration of the abdominal wall integrity, and maintenance of the abdominal wall muscle tension to prevent the occurrence of abdominal wall hernia. When treating huge full-thickness defects, composite autologous tissue flaps are a good option for the repair.
   CASE SUMMARY
   This study reported the case of a 43-year-old male patient suffering from full-thickness abdominal wall defects complicated with necrosis of multiple bowel segments and duodenal leak following high-voltage burns involving the left upper limb and abdomen. After debridement for abdominal electric burns and end-to-end anastomosis for the necrotic bowels, reconstruction with acellular dermal matrix grafting and vacuum sealing drainage were performed for temporary abdominal closure. The remaining 18 cm x 15 cm full-thickness abdominal wall defect was repaired using a combined anterolateral thigh and tensor fascia lata free flap. The proposed method achieved the functional reconstruction of the abdominal wall.
   CONCLUSION
   This approach restored the abdominal wall integrity, maintained certain muscle tension, avoided abdominal hernia, reached satisfactory aesthetic effect, and resulted in no complications in the grafting regions.
C1 [Wang, Jun] Hainan Med Univ, Hainan Affiliated Hosp, Hainan Gen Hosp, Dept Burn & Skin Repair Surg, 19 Xiuhua Rd, Haikou 570311, Hainan, Peoples R China.
C3 Hainan Medical University
RP Wang, J (通讯作者)，Hainan Med Univ, Hainan Affiliated Hosp, Hainan Gen Hosp, Dept Burn & Skin Repair Surg, 19 Xiuhua Rd, Haikou 570311, Hainan, Peoples R China.
EM wanggg23@hainmc.edu.cn
CR Caliceti Umberto, 2019, JPRAS Open, V22, P55, DOI [10.1016/j.jpra.2019.09.003, 10.1016/j.jpra.2019.09.003]
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NR 9
TC 2
Z9 4
U1 0
U2 6
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD MAR 6
PY 2021
VL 9
IS 7
BP 1734
EP 1740
DI 10.12998/wjcc.v9.i7.1734
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QX0CK
UT WOS:000629016900026
PM 33728319
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Mastrocco, A
   Prittie, J
AF Mastrocco, Alicia
   Prittie, Jennifer
TI Early and aggressive surgical debridement and negative pressure wound
   therapy to treat necrotizing fasciitis in three dogs
SO VETERINARY SURGERY
LA English
DT Article
ID SOFT-TISSUE INFECTIONS; DETERMINANTS; MANAGEMENT; DIAGNOSIS; MORTALITY;
   NEED
AB Objective To report the management and outcomes of dogs with necrotizing fasciitis (NF) treated with early, aggressive surgical debridement and negative pressure wound therapy (NPWT).
   Study design Short case series.
   Animals Three dogs surgically treated for NF.
   Methods Clinical signs in the three dogs included an identified wound, severe pain, fever, and progressive erythema. A tentative diagnosis of NF was based on the presence of suppurative inflammation and intracellular bacteria seen in fine needle aspirates and clinical progression in each case. Each dog was treated with surgical debridement within 6 hours of clinical suspicion for NF. Necrosis affected multiple tissue layers was noted surgical exploration. Systemic supportive care and antibiotherapy were also provided for 3 to 4 weeks postoperatively.
   Results Three surgical debridements were required in two dogs, and four surgical debridements were required in one dog. All of the surgical sites were managed with NPWT until final primary closure was possible at 4, 5, and 6 days after initial surgery. Results of histopathology and culture of the surgical sites were consistent with NF as described in each case. All dogs survived to discharge and long-term follow up.
   Conclusion Management with early surgery, multiple debridements, and the use of NPWT led to resolution of NF in three dogs.
C1 [Mastrocco, Alicia; Prittie, Jennifer] Anim Med Ctr, Emergency & Crit Care, New York, NY USA.
RP Mastrocco, A (通讯作者)，510 E 62nd St, New York, NY 10065 USA.
EM alicia.mastrocco@amcny.org
OI Mastrocco, Alicia/0000-0002-0110-9927
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NR 19
TC 1
Z9 1
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD NOV
PY 2021
VL 50
IS 8
BP 1662
EP 1669
DI 10.1111/vsu.13576
EA MAR 2021
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA WN9JB
UT WOS:000629209800001
PM 33724500
DA 2026-07-24
ER
PT J
AU Wu, YH
   Wang, JK
   Dai, JT
   Wang, G
   Li, HB
   Li, YG
   Wu, C
   Wei, GH
AF Wu, Yuhao
   Wang, Junke
   Dai, Jiangtao
   Wang, Gang
   Li, Hongbo
   Li, Yonggang
   Wu, Chun
   Wei, Guanghui
TI Is vacuum-assisted closure therapy feasible for children with deep
   sternal wound infection after cardiac surgery? The pooling results from
   current literature
SO ARTIFICIAL ORGANS
LA English
DT Article
DE children; congenital heart diseases; deep sternal wound infections;
   outcomes; vacuum&#8208; assisted closure
ID POST-STERNOTOMY MEDIASTINITIS; POSTOPERATIVE MEDIASTINITIS; SYSTEM
AB Vacuum-assisted closure (VAC) has been used for children with deep sternal wound infections (DSWI); however, the safety and efficiency have not been determined. A meta-analysis was performed for outcomes of VAC therapy in children with DSWI after cardiac surgery. Electronic databases, including PubMed, Scopus, and Cochrane Library CENTRAL were searched systematically from January 1990 to October 2020 for the literature which reported the outcomes of VAC therapy for children with DSWI after cardiac surgery. Meta-regression and subgroup analyses were performed to find risk factors for prolonged length of VAC therapy and hospital stay. Eleven studies were included in this study, involving 217 subjects. VAC therapy was performed due to mediastinitis after congenital heart diseases (CHD) repair. In children with DSWI after cardiac surgery, length of VAC therapy, and hospital stay were 11.1 days (95% CI, 9.6-12.5 days) and 29.8 days (95% CI, 22.8-36.9 days), respectively. Incidence of infectious and wound-related complications was 8.5% (95% CI, 4.1%-13.0%). Overall mortality in this setting was 5.8% (95% CI, 2.5%-9.1%). In conclusion, in children with DSWI after cardiac surgery, length of VAC therapy and hospital stay were 11.1 and 29.8 days, respectively. Overall mortality was 5.8%. Although not significant, delayed chest closure, complex CHD, and Gram-negative bacilli/fungal infections may potentially contribute to prolonged duration of VAC treatment.
C1 [Wu, Yuhao; Dai, Jiangtao; Wang, Gang; Li, Hongbo; Li, Yonggang; Wu, Chun] Chongqing Med Univ, Dept Cardiothorac Surg, Childrens Hosp, Chongqing, Peoples R China.
   [Wu, Yuhao; Wang, Junke; Dai, Jiangtao; Wang, Gang; Li, Hongbo; Li, Yonggang; Wu, Chun; Wei, Guanghui] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, China Int Sci & Technol Cooperat Base Child Dev &, Minist Educ,Key Lab Child Dev & Disorders, Chongqing, Peoples R China.
C3 Chongqing Medical University
RP Wu, C; Wei, GH (通讯作者)，Chongqing Med Univ, Childrens Hosp, 136 Zhongshan Second Rd, Chongqing 400014, Peoples R China.
EM 250734291@qq.com; 250734291@qq.com
RI wang, jun ke/LFU-1628-2024
CR Anslot C, 2007, ANN THORAC SURG, V84, P423, DOI 10.1016/j.athoracsur.2007.03.064
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NR 27
TC 8
Z9 11
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-564X
EI 1525-1594
J9 ARTIF ORGANS
JI Artif. Organs
PD AUG
PY 2021
VL 45
IS 8
BP 827
EP 837
DI 10.1111/aor.13936
EA MAR 2021
PG 11
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA TM0BA
UT WOS:000630082500001
PM 33569832
DA 2026-07-24
ER
PT J
AU Chang, H
   Maldonado, TS
   Rockman, CB
   Cayne, NS
   Berland, TL
   Barfield, ME
   Jacobowitz, GR
   Sadek, M
AF Chang, Heepeel
   Maldonado, Thomas S.
   Rockman, Caron B.
   Cayne, Neal S.
   Berland, Todd L.
   Barfield, Michael E.
   Jacobowitz, Glenn R.
   Sadek, Mikel
TI Closed incision negative pressure wound therapy may decrease wound
   complications in major lower extremity amputations
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
DE Amputation; Peripheral artery disease; Negative pressure wound therapy;
   Below-knee amputation; Above-knee amputation
ID TRIAL
AB Objective: Wound complications after major lower extremity amputations (LEAs) are a cause of significant morbidity in vascular surgery patients. Recent publications have demonstrated the efficacy of the closed incision negative pressure dressing at preventing surgical site infections (SSIs); however, there are few data on its use in major LEAs. This study sought to assess if closed incision negative pressure wound therapy (NPWT) would decrease the risk of complications as compared with a standard dressing in patients with peripheral vascular disease undergoing major LEA.
   Methods: Fifty-four consecutive patient limbs with a history of peripheral arterial disease underwent below-knee or above-knee amputations. This was a retrospective review of a prospectively maintained database from January 2018 to December 2019, and it included 23 amputations in the NPWT group and 31 amputations in the standard dressing group. NPWT using the PREVENA system was applied intraoperatively at the discretion of the operating surgeon and removed 5 to 7 days postoperatively. The standard group received a nonadherent dressing with an overlying compression dressing. Amputation incisions were assessed and wound complications were recorded. Student's t-test and two-sample proportion z-test were used for statistical analysis. A P value of less than .05 was considered statistically significant.
   Results: For comorbidities, there was a higher incidence of tobacco use in the NPWT as compared with the standard group (44% vs 13%; P= .011), as well as trends toward increased prior amputations, anemia, hyperlipidemia, and chronic obstructive pulmonary disorder in the NPWT group. For risk factors, there were more dirty wounds in the NPWT as compared with the standard group (52% vs 26%; P= .046). For outcomes, there were fewer wound complications in the NPWT as compared with the standard group (13% vs 39%; P = .037). The types of wound-related complications in the NPWT group included one wound dehiscence with a deep SSI, one superficial SSI, and one incision line necrosis. In the standard group, there were four wound dehiscences with deep SSI, three superficial SSIs, four incision line necroses, and one stump hematoma. The rates of perioperative mortality and amputation revision did not differ significantly between the NPWT and the standard groups (3% vs 4% and 4.3% vs 10%, respectively).
   Conclusions: Closed incision NPWT may decrease the incidence of wound complications in vascular patients undergoing major LEA. This held true even among a population that was potentially at higher risk. This therapy may be considered for use in lower extremity major amputations.
C1 [Chang, Heepeel; Maldonado, Thomas S.; Rockman, Caron B.; Cayne, Neal S.; Berland, Todd L.; Barfield, Michael E.; Jacobowitz, Glenn R.; Sadek, Mikel] NYU, Dept Surg, Div Vasc & Endovasc Surg, Langone Med Ctr, 530 First Ave,Ste 6F, New York, NY 10016 USA.
C3 NYU Langone Medical Center; New York University
RP Sadek, M (通讯作者)，NYU, Dept Surg, Div Vasc & Endovasc Surg, Langone Med Ctr, 530 First Ave,Ste 6F, New York, NY 10016 USA.
EM mikel.sadek@nyulangone.org
RI ; Rockman, Caron/PXB-2365-2026
OI Rockman, Caron/0000-0001-6955-4632; cayne, neal/0000-0003-4957-2723;
   Jacobowitz, Glenn/0000-0002-8136-2518
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NR 28
TC 27
Z9 29
U1 2
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD MAR
PY 2021
VL 73
IS 3
BP 1041
EP 1047
DI 10.1016/j.jvs.2020.07.061
EA FEB 2021
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA QZ7JO
UT WOS:000630898900069
PM 32707380
OA Bronze
DA 2026-07-24
ER
PT J
AU Chen, RF
   Chen, JP
   Peng, AJ
   Yang, LH
   Zhou, RJ
AF Chen, Ruifu
   Chen, Junpeng
   Peng, Ajing
   Yang, Lihua
   Zhou, Ruijuan
TI Clinical therapeutic evaluation of vacuum sealing drainage and precise
   ultrasound-guided debridement in the treatment of non-lactational
   mastitis
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE vacuum sealing drainage; precise ultrasound-guided debridement; surgery;
   non-lactational mastitis; granulomatous lobular mastitis; mammary duct
   ectasia; periduct mastitis
AB The aim of the present study was to compare the efficacy of vacuum sealing drainage (VSD) and precise ultrasound-guided debridement in the treatment of non-lactational mastitis and to determine the optimal surgical treatment. A set of 60 cases diagnosed with non-lactational mastitis who had received surgical treatment at the Department of Thoracic and Breast Surgery of Xiamen Hospital of Traditional Chinese Medicine (Xiamen, China) between July 2017 and June 2019 were included. According to the surgical method, 30 patients were assigned to the VSD group and 30 patients were assigned to the precise ultrasound-guided debridement group. The clinicopathological data of the two groups were compared. The overall rates of recurrence and new incidence were 6.8 and 8.5%, respectively. The mean total disease course was 5.3 months and all of the patients were cured after treatment. Except for the hospitalization time and postoperative pain scores, the clinicopathological data between the two groups were similar. The hospitalization time in the VSD group was significantly longer than that in the precise ultrasound-guided debridement group. Pain scores on the first and third days after the operation in the precise ultrasound-guided debridement group were significantly higher than those in the VSD group (P=0.008 and 0.001, respectively). In conclusion, the efficacies of VSD and precise ultrasound-guided debridement for the treatment of non-lactational mastitis were generally both satisfactory without significant differences. Of note, the former is suitable for patients with inverted nipples and obvious skin ulcerations, while the latter is mainly suitable for patients with abscesses, small surgical incisions and those who require short hospital stays.
C1 [Chen, Ruifu; Chen, Junpeng; Peng, Ajing; Yang, Lihua; Zhou, Ruijuan] Xiamen Hosp Tradit Chinese Med, Dept Thorac & Breast Surg, 1739 Xianyue Rd, Xiamen 361000, Fujian, Peoples R China.
RP Chen, JP (通讯作者)，Xiamen Hosp Tradit Chinese Med, Dept Thorac & Breast Surg, 1739 Xianyue Rd, Xiamen 361000, Fujian, Peoples R China.
EM cjp7978@sohu.com
RI JUNPENG, CHEN/NSV-3637-2025
FU research project of Fujian University of Traditional Chinese Medicine
   [XB2017069]; National Natural Science Foundation of China [81704094];
   National Talent Training Program of Innovation in Traditional Chinese
   Medicine [81704094]
FX This project was supported by the research project of Fujian University
   of Traditional Chinese Medicine (grant no. XB2017069), the National
   Natural Science Foundation of China (grant no. 81704094) and the
   National Talent Training Program of Innovation in Traditional Chinese
   Medicine (grant no. 81704094).
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NR 30
TC 5
Z9 6
U1 1
U2 18
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAY
PY 2021
VL 21
IS 5
AR 480
DI 10.3892/etm.2021.9911
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA RA5YO
UT WOS:000631494600001
PM 33767775
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhu, J
   Wang, FF
   Yan, L
   Wang, JW
   Wu, MZ
   Hu, R
   An, Y
AF Zhu, Jin
   Wang, Fangfang
   Yan, Li
   Wang, Junwen
   Wu, Mingzheng
   Hu, Rui
   An, Ying
TI Negative pressure wound therapy enhances bone regeneration compared with
   conventional therapy in a rabbit radius gap-healing model
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE negative pressure wound therapy; bone regeneration; mesenchymal stem
   cells; vascular endothelial growth factor; bone morphogenetic protein 2;
   osteopontin
AB Negative pressure wound therapy (NPWT) has been recognized as an effective method for the treatment of intractable wounds. However, its effects on bone healing remain to be elucidated. Our previous study demonstrated that NPWT induced cell proliferation and osteoblastic differentiation of rat periosteum-derived mesenchymal stem cells (P-MSCs). It was reported that following NPWT treatment, the expression of the mechanotransduction molecule integrin beta 5 is increased, indicating that NPWT may serve an active role in fracture healing by enhancing bone formation and reducing bone resorption. The present study sought to further investigate the efficacy of NPWT on the bone regeneration process in a rabbit radial gap-healing model. All rabbits with radial defects were randomly divided into two groups: NPWT and control groups. Continuous negative pressure at -125 mmHg was applied to all rabbits. Furthermore, X-ray imaging and scoring on day 7, 14, 21 and 28 postoperatively were performed to evaluate new bone formation. Histological changes were determined via hematoxylin and eosin and Masson's trichrome staining at 2- and 4-weeks following surgery. In addition, vimentin-positive cells located in the periosteum were detected via immunohistochemical examination on day 3 post operation. Finally, protein expression levels of vascular endothelial growth factor (VEGF), bone morphogenetic protein (BMP)-2 and osteopontin (OPN) were evaluated using western blot analysis on the 2nd and 4th week following NPWT. X-ray and histological examination revealed that the bone-healing processes in the NPWT group were faster compared with the control group. Additionally, compared with the control group, the NPWT group exhibited higher X-ray scores, increased percentage of positive vimentin-stained cells and upregulated expression of VEGF, BMP-2 and OPN proteins. The aforementioned findings suggest that NPWT, under a continuous negative pressure of -125 mmHg, may accelerate bone regeneration by enhancing MSC proliferation, osteoblastic differentiation and VEGF, BMP-2 and OPN expression.
C1 [Zhu, Jin; Yan, Li; Wang, Junwen; Wu, Mingzheng; Hu, Rui; An, Ying] Huazhong Univ Sci & Technol, Wuhan Hosp 4, Puai Hosp, Tongji Med Coll,Dept Orthoped, 473 Hanzheng St, Wuhan 430000, Hubei, Peoples R China.
   [Wang, Fangfang] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan 430000, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Yan, L (通讯作者)，Huazhong Univ Sci & Technol, Wuhan Hosp 4, Puai Hosp, Tongji Med Coll,Dept Orthoped, 473 Hanzheng St, Wuhan 430000, Hubei, Peoples R China.
EM swyanli666@hotmail.com
RI ; Wang, Fangfang/KII-9109-2024
OI Wu, Mingzheng/0000-0001-8282-4510; 
FU Natural Science Fund of Hubei Provincial Health Commission [2020CFB464];
   Wuhan Municipal Health Commission [WX20Q15]
FX The present study was supported by the Natural Science Fund of Hubei
   Provincial Health Commission (grant no. 2020CFB464) and Wuhan Municipal
   Health Commission (grant no. WX20Q15).
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NR 38
TC 9
Z9 11
U1 1
U2 13
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAY
PY 2021
VL 21
IS 5
AR 474
DI 10.3892/etm.2021.9905
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA RA5ZS
UT WOS:000631497600001
PM 33767769
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, X
   Zhang, H
   Li, YX
   Chen, Y
   Deng, W
   Zhang, W
AF Liu, Xi
   Zhang, Hui
   Li, Yaxing
   Chen, Yu
   Deng, Wei
   Zhang, Wen
TI Application of Negative Pressure Wound Therapy in Total Ankle
   Replacement
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE ankle arthroplasty; closed incision; infection; joint replacement; lower
   extremity; negative pressure wound therapy
AB The efficacy and safety of incisional negative pressure wound therapy (iNPWT) was evaluated following total ankle replacement. A retrospective cohort study was conducted in patients who underwent total ankle replacement between January 2010 and June 2018. Following joint replacement, the patients received iNPWT (iNPWT group) or sterile dressings (Control group). Infection rate, wound complication incidence, length of stay, visual analogue scale, American Orthopedic Foot and Ankle Society, and short-form 36 scales, and ankle range of motion were assessed 1 week, 2 weeks, 1 month, 3 months, 6 months, and 12 months postoperatively. Thirty-four patients (n = 13 iNPWT and n = 21 Control) were included. No significant differences were found in baseline data. During follow-up, one Control patient developed a superficial infection at the incision. Wound complications developed in 4 Control patients and 1 iNPWT patient; although this was not statistically significant. Length of stay was similar between the 2 groups. Two weeks after surgery, the range of visual analogue scale (2.1 vs 1.4), American Orthope-dic Foot and Ankle Society (13.7 vs 9.7), and short-form 36 scale (9.0 vs 6.5) improvement, and increase of ankle range of motion (9.2 vs 6.1) was significantly larger in the study group than in the control group (p < .05). Three months to 1 year after the surgery, this difference was no longer statistically significant. The application of iNPWT following total ankle arthroplasty helped reduce postoperative pain, improve ankle function, and improve patient quality of life. However, these benefits were no longer statistically significant 3 months to 1 year after surgery. ? 2020 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Liu, Xi; Zhang, Hui; Li, Yaxing] West China Hosp, Dept Orthoped Surg, 37 Guoxue Ave, Chengdu, Sichuan, Peoples R China.
   [Chen, Yu; Deng, Wei] Shangjin Nanfu Hosp, Dept Orthoped Surg, Chengdu, Sichuan, Peoples R China.
   [Zhang, Wen] Chengdu Univ Tradit Chinese Med, Affiliated Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University; Chengdu University of Traditional Chinese Medicine
RP Zhang, H (通讯作者)，West China Hosp, Dept Orthoped Surg, 37 Guoxue Ave, Chengdu, Sichuan, Peoples R China.
EM zhanghuishangjin@163.com
RI Zhang, Hui/OTH-2486-2025
CR Agarwal A, 2019, PLAST RECONSTR SURG, V143, p21S, DOI 10.1097/PRS.0000000000005308
   Batra RK, 2014, INDIAN J SURG, V76, P162, DOI 10.1007/s12262-012-0770-7
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NR 23
TC 8
Z9 9
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAR-APR
PY 2021
VL 60
IS 2
BP 283
EP 287
DI 10.1053/j.jfas.2020.08.021
EA MAR 2021
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA RA9EI
UT WOS:000631721500012
PM 33223439
DA 2026-07-24
ER
PT J
AU Giordano, P
   Schembari, E
   Keshishian, K
   Leo, CA
AF Giordano, P.
   Schembari, E.
   Keshishian, K.
   Leo, C. A.
TI Negative pressure-assisted endoscopic pilonidal sinus treatment
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE Pilonidal sinus; Pilonidal disease; EPSiT; NPWT; Minimally invasive
   treatment
AB Background Endoscopic pilonidal sinus treatment (EPSiT) is a novel minimally invasive option for the treatment of pilonidal sinus disease (PSD). To optimise the postoperative wound management after EPSiT, an ultraportable negative pressure wound therapy (NPWT) device was used. The aim of this study was to assess the clinical outcomes of negative pressure-assisted (NPA) EPSiT. Methods All patients with PSD treated by EPSIT from November 2017 to October 2019 were managed postoperatively with a commercially available NPTW dressing applied to the wound. All patients were prospectively entered into a dedicated database. Primary outcome measures were healing rate and return to normal activities. Secondary outcomes were postoperative complications and patient satisfaction. Results Thirteen male patients underwent NPA EPSiT (mean age 27.8 years, range 16-52 years). Two patients had previous surgery for PSD. The mean follow-up was 14 months (range 4-28 months). In two patients, only partial healing of the tract was achieved. One of these required a further successful NPA EPSiT, while the other one refused any other treatment because of the lack of symptoms. Eight patients were very satisfied and 5 were satisfied with this treatment. Conclusions NPA EPSiT is a simple method for improving postoperative wound management, facilitating a quicker recovery and possibly improving overall patient satisfaction.
C1 [Giordano, P.; Schembari, E.; Keshishian, K.; Leo, C. A.] Royal London Hosp, Dept Colorectal Surg, Whitechapel Rd, London E1 1RR, England.
   [Leo, C. A.] Imperial Coll London, Dept Canc & Surg, London, England.
C3 Barts Health NHS Trust; Royal London Hospital; Imperial College London
RP Giordano, P (通讯作者)，Royal London Hosp, Dept Colorectal Surg, Whitechapel Rd, London E1 1RR, England.
EM p.giordano@londoncolorectal.org
RI Schembari, Elena/NEU-2962-2025; Leo, Cosimo Alex/AAJ-9433-2020
OI Leo, Cosimo Alex/0000-0001-5759-0345; Giordano,
   Pasquale/0000-0002-3603-4574
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   FDA, 2010, PREVENATM INCISION M
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NR 22
TC 11
Z9 13
U1 0
U2 1
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD JUN
PY 2021
VL 25
IS 6
BP 739
EP 743
DI 10.1007/s10151-021-02431-w
EA MAR 2021
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA SC8OA
UT WOS:000631754200002
PM 33755853
DA 2026-07-24
ER
PT J
AU Di Re, AM
   Wright, D
   Toh, JWT
   El-Khoury, T
   Pathma-Nathan, N
   Gosselink, MP
   Khanijaun, S
   Raman, S
   Ctercteko, G
AF Di Re, A. M.
   Wright, D.
   Toh, J. W. T.
   El-Khoury, T.
   Pathma-Nathan, N.
   Gosselink, M. P.
   Khanijaun, S.
   Raman, S.
   Ctercteko, G.
TI Surgical wound infection prevention using topical negative pressure
   therapy on closed abdominal incisions-the ?SWIPE IT? randomized clinical
   trial
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE Colorectal surgery; Surgical site infections; Trauma surgery; Emergency
   surgery; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; SITE INFECTION; COLORECTAL SURGERY;
   OBESE-PATIENTS
AB Background: Surgical site infections (SSIs) are the most common cause of healthcare associated infections in surgical patients. It is unclear whether incisional negative pressure wound therapy (NPWT) can reduce the risk of SSIs in patients after open abdominal surgery.
   Methods: A prospective, non-blinded multi-centre randomized controlled trial (RCT) was performed to evaluate the incidence of SSI post-laparotomy using incisional NPWT compared with a standard dressing. The primary outcome was the rate of superficial SSI.
   Results: A total of 124 patients (61 patients in the NPWT arm and 63 patients in the control arm) were included. One hundred and nine (87.9%) patients underwent colorectal surgery; 61 patients (49.2%) had emergency surgery. There were more superficial SSIs in the control group than in the NPWT group, although not statistically significant (20.6% vs 9.8%, P=0.1). Upon multiple logistic regression analysis, control dressings were associated with increased risk of superficial SSI although again, not statistically significant (odds ratio (OR) 2.41, 95% confidence interval (CI) 0.81-7.17, P=0.11). There was no superficial non-SSI related wound dehiscence in the NPWT group compared with 9.5% in the control group (P=0.03). There was no difference in postoperative complications (P=0.15), nor in other wound complications (P=0.79).
   Conclusion: NPWT was not associated with decreased superficial SSI in this RCT. However, there was a statistically significant reduction in superficial wound dehiscence with NWPT dressings. The results of this study should be included in meta-analyses for better evaluation of NPWT on closed abdominal incisions.
C1 [Di Re, A. M.; Wright, D.; Toh, J. W. T.; El-Khoury, T.; Pathma-Nathan, N.; Gosselink, M. P.; Khanijaun, S.; Raman, S.; Ctercteko, G.] Westmead Hosp, Dept Colorectal Surg, Cnr Hawkesbury Rd & Darcy Rd, Westmead, NSW 2145, Australia.
   [Di Re, A. M.] Univ Sydney, Sch Phys, Sydney, NSW, Australia.
   [Wright, D.; Ctercteko, G.] Blacktown Mt Druitt Hosp, Dept Surg, Mt Druitt, NSW, Australia.
   [Toh, J. W. T.; Ctercteko, G.] Univ Sydney, Sch Med, Sydney, NSW, Australia.
   [El-Khoury, T.] Notre Dame Univ, Sch Med, Sydney, NSW, Australia.
   [Gosselink, M. P.] Dr Horacio E Oduber Hosp, Oranjestad, Aruba.
   [Raman, S.] Univ Hosp Birmingham NHS Fdn Trust, Heartlands Hosp, Birmingham, W Midlands, England.
C3 NSW Health; Westmead Hospital; University of Sydney; University of
   Sydney; NSW Health; Blacktown & Mount Druitt Hospital; University of
   Sydney; The University of Notre Dame Australia; University of
   Birmingham; Heart of England NHS Foundation Trust; Heartlands Hospital
RP Di Re, AM (通讯作者)，Westmead Hosp, Dept Colorectal Surg, Cnr Hawkesbury Rd & Darcy Rd, Westmead, NSW 2145, Australia.
EM Angelina.dire@gmail.com
RI ; Gosselink, Martijn/D-1564-2009
OI Khanijaun, Sukhwant/0000-0002-6256-2522; El-Khoury,
   Toufic/0009-0007-2133-6063; Gosselink, Martijn/0000-0002-6396-3977
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NR 31
TC 15
Z9 19
U1 1
U2 8
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD APR
PY 2021
VL 110
BP 76
EP 83
DI 10.1016/j.jhin.2021.01.013
EA FEB 2021
PG 8
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA RB8FP
UT WOS:000632342500011
PM 33516795
DA 2026-07-24
ER
PT J
AU Kotani, S
   Inoue, Y
   Wakatabe, M
   Yashiro, H
   Hase, M
AF Kotani, Sohsyu
   Inoue, Yoshito
   Wakatabe, Makoto
   Yashiro, Hideki
   Hase, Manabu
TI Successful Endovascular Repair of an Aortobronchial Fistula due to
   Takayasu Arteritis
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
AB Endovascular approaches to treating a diseased ascending aorta are challenging. We report the use of an endovascular occlusion device for successful closure of a ruptured penetrating atherosclerotic ulcer of an ascending aorta. A 47-year-old female patient with Takayasu arteritis complained of a worsening hemoptysis. She had a history of Bentall procedure for a sinus of Valsalva aneurysm and redo surgery for a ruptured penetrating atherosclerotic ulcer close to the distal anastomosis. She developed methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis after the second procedure and required negative pressure wound therapy. Computed tomographic angiography revealed recurrence of a ruptured penetrating aortic ulcer and an aortobronchial fistula. Because of the high risk of redo sternotomy after MRSA mediastinitis, we used an endovascular occlusion device to achieve successful percutaneous closure. The patient was discharged without any complications. Postoperative computed tomography scans showed that the endovascular device was positioned without migration and that complete thrombosis of the penetrating atherosclerotic ulcer was achieved. This is the first report on endovascular repair of a ruptured penetrating atherosclerotic ulcer of the ascending aorta in Takayasu arteritis.
C1 [Kotani, Sohsyu; Inoue, Yoshito; Wakatabe, Makoto] Hiratsuka City Hosp, Dept Cardiovasc Surg, Minamihara 1-19-1, Hiratsuka, Kanagawa, Japan.
   [Yashiro, Hideki; Hase, Manabu] Hiratsuka City Hosp, Dept Radiol, Hiratsuka, Kanagawa, Japan.
RP Kotani, S (通讯作者)，Hiratsuka City Hosp, Dept Cardiovasc Surg, Minamihara 1-19-1, Hiratsuka, Kanagawa, Japan.
EM sohsyu_k@yahoo.co.jp
RI Inoue, Yoshito/KIK-5596-2024
OI Inoue, Yoshito/0000-0001-8297-4797
CR Baikoussis NG, 2017, J VASC SURG, V66, P1587, DOI 10.1016/j.jvs.2017.07.064
   Ghoreishi M, 2020, ANN THORAC SURG, V109, P678, DOI 10.1016/j.athoracsur.2019.07.015
   Huh U, 2017, ANN THORAC SURG, V104, pE413, DOI 10.1016/j.athoracsur.2017.08.003
   Jung JH, 2018, EUR J VASC ENDOVASC, V55, P888, DOI 10.1016/j.ejvs.2018.02.030
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   Noble S, 2012, CATHETER CARDIO INTE, V79, P334, DOI 10.1002/ccd.23094
NR 6
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD FEB
PY 2021
VL 71
AR 533.e13
DI 10.1016/j.avsg.2020.08.152
EA FEB 2021
PG 4
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA RC0NM
UT WOS:000632500700059
PM 32949744
DA 2026-07-24
ER
PT J
AU Almeida, IR
   Coltro, PS
   Gonçalves, HOC
   Westin, AT
   Almeida, JB
   Lima, RVKS
   Silva, MF
   Farina, JA Jr
AF Almeida, Ivan R.
   Coltro, Pedro S.
   Goncalves, Henrique O. C.
   Westin, Andrezza T.
   Almeida, Juliano B.
   Lima, Renan V. K. S.
   Silva, Marcelo F.
   Farina Junior, Jayme A.
TI The role of negative pressure wound therapy (NPWT) on the treatment of
   pyoderma gangrenosum: A systematic review and personal experience
SO WOUND REPAIR AND REGENERATION
LA English
DT Review
DE negative pressure therapy; pyoderma gangrenosum; surgical treatment;
   systemic treatment; wound healing
ID VACUUM-ASSISTED CLOSURE; NECROTIZING FASCIITIS; SURGICAL INTERVENTION;
   LEG ULCERS; MANAGEMENT; PATHOPHYSIOLOGY; COMBINATION; INFECTION;
   DIAGNOSIS; GRAFT
AB Pyoderma gangrenosum (PG) is a rare painful ulcerative neutrophilic inflammatory skin disease, necessitating a high level of diagnostic suspicion associated with appropriate treatment to avoid progression. Negative pressure wound therapy (NPWT) has been efficiently used in the treatment of different types of wounds. However, the role of NPWT in the management of PG is still controversial, due to the risk of the pathergy phenomenon. In this article, we conducted a systematic review (according to the PRISMA guidelines) on the use of NPWT in the treatment of PG, and we report our personal experience with two patients treated with this device. The result of the review showed that articles on the topic are, in their entirety, of low levels of evidence, such as case series, case reports, and reviews. Improvement in wound healing with the use of NPWT was observed in 85.1% of the patients studied. Besides, a significant association between improvement in wound healing with NPWT and immunosuppressive therapy was observed. Regarding the cases reported here, both showed good outcomes with the use of NPWT and skin graft during the treatment of PG injuries. Due to the rarity of PG, there is a scarcity of studies with robust evidence for standardization and comparison between treatments, which consequently makes it difficult to select therapeutic options. However, based on this systematic review and reported cases, we consider NPWT a safe option for adjuvant treatment of wounds caused by PG if combined with systemic immunosuppression, which plays a key role in greater chances of successful treatment. This approach should be recommended, whenever possible, associated with skin grafting to accelerate wound closure. The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: a systematic review and personal experience.
C1 [Almeida, Ivan R.; Coltro, Pedro S.; Goncalves, Henrique O. C.; Almeida, Juliano B.; Lima, Renan V. K. S.; Silva, Marcelo F.; Farina Junior, Jayme A.] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Plast Surg, Sao Paulo, Brazil.
   [Westin, Andrezza T.] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Dermatol, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Coltro, PS (通讯作者)，Univ Sao Paulo, Ribeirao Preto Med Sch, Div Plast Surg, Av Bandeirantes 3900,9th Floor, Ribeirao Preto, SP, Brazil.
EM psc@usp.br
RI Silva, Marcelo/AGR-1056-2022; Coltro, Pedro/P-5349-2014; Farina, Jayme
   A/F-9518-2012
OI de Rezende Almeida, Ivan/0000-0001-7680-4986; Coraspe Gonçalves,
   Henrique Ovidio/0000-0002-7726-0869; Coltro, Pedro/0000-0002-0164-4508;
   Farina, Jayme A/0000-0002-9232-367X
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NR 79
TC 22
Z9 24
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY
PY 2021
VL 29
IS 3
BP 486
EP 494
DI 10.1111/wrr.12910
EA MAR 2021
PG 9
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA SC5OP
UT WOS:000633518000001
PM 33772964
DA 2026-07-24
ER
PT J
AU Brega, C
   Calvi, S
   Albertini, A
AF Brega, Carlotta
   Calvi, Simone
   Albertini, Alberto
TI Use of a negative pressure wound therapy system over closed incisions
   option in preventing post-sternotomy wound complications
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE negative pressure therapy; post&#8208; sternotomy infections; surgical
   wound infection
ID MEDIAN STERNOTOMY; INFECTIONS; DRESSINGS; RISK
AB Post-sternotomy surgical site infections may be serious complications responsible for increased morbidity, mortality and length of hospital stay. A variety of wound-healing strategies can be used over closed surgical incisions, including negative pressure wound therapy (NPWT). The aim of the study is to assess sternal wound complications after heart surgery using NPWT in patients at risk for surgical site complication. Considered risk factors affecting wound healing were type 2 diabetes, Body Mass Index (BMI) >30, chronic obstructive pulmonary disease (COPD), chronic renal failure (CRF) and myocardial revascularization by double mammary artery harvesting. With these premises, 90 patients were selected: 30 patients received traditional gauze dressings, 30 advanced dressings (hydrocolloid and carboxymethyl cellulose) and 30 patients NPWT. Thirty-four patients (37.7%) had two risk factors, 41 patients (45.5%) were affected by three risk factors and 15 patients (16.6%) by four risk factors. The NPWT group had lower rates of diabetes and CRF and only one patient presented four risk factors. With regard to surgical times and types of surgical procedure, no significant differences were observed within the three groups. The patients who received NPWT over closed incision experimented a significantly lower rate of deep sternal complication over traditional gauze and hydrocolloid and carboxymethyl cellulose dressings.
C1 [Brega, Carlotta; Calvi, Simone; Albertini, Alberto] GVM Care & Res, Cardiovasc Dept, Maria Cecilia Hosp, Cotignola, Italy.
C3 Maria Cecilia Hospital
RP Brega, C (通讯作者)，GVM Care & Res, Maria Cecilia Hosp, Via Corriera 1, I-48010 Cotignola, RA, Italy.
EM carlottabrega@icloud.com
RI Brega, Carlotta/J-4656-2019; Albertini, Alberto/KQV-4794-2024
OI Brega, Carlotta/0000-0002-6935-9295; 
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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NR 18
TC 9
Z9 10
U1 1
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2021
VL 29
IS 5
BP 848
EP 852
DI 10.1111/wrr.12914
EA MAR 2021
PG 5
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA UK1FO
UT WOS:000634288100001
PM 33780088
DA 2026-07-24
ER
PT J
AU Elhessy, AH
   Chaudhry, AR
   Hammouda, A
   Giacobbe, SD
   Gesheff, MG
   Conway, JD
AF Elhessy, Ahmed H.
   Chaudhry, Arif R.
   Hammouda, Ahmed, I
   Giacobbe, Shawn D.
   Gesheff, Martin G.
   Conway, Janet D.
TI Experience with negative-pressure wound therapy with instillation in
   complex infected orthopaedic wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE infected orthopaedic wounds; negative&#8208; pressure wound therapy with
   instillation; NPWTi
ID RECOMMENDATIONS; SALINE
AB Chronic exudative wounds are frequently seen in hospitalised patients, consuming hospital resources and leading to increased morbidity. Negative-pressure therapy (NPWT) with topical instillation "NPWTi" may be used to improve the wound healing process, with the unique features (removal of wound exudate, edema reduction, promotion of tissue perfusion and granulation tissue formation, as well as drawing the edges of the wound to facilitate, in addition to the cyclic cleansing mechanism). This report is a descriptive study of our experience with NPWTi on complex infected orthopaedic wounds as a potential method to decrease the need for multiple surgical debridements required for the closure of such wounds. A prospective observational study was conducted. Twenty patients with complex infected orthopaedic wounds were enrolled in our study. These patients were consulted by the Bone and Joint Infection Service and enrolled to receive NPWTi intraoperatively and to be used during their inpatient stay. Twenty patients with 20 complex infected lower limb wounds were included in our study. Of all the 20 wounds, the etiology was post-surgical in 80% (n = 16) and post-traumatic in 20% (n = 4). None of the patients received previous treatment with conventional NPWT before participation in the study. There were 11 males (55%) and 9 females (45%) with an average age of 57 years (22-83). All wounds were located in the lower limbs, with 25% leg (n = 5), 20% thigh (n = 4), 20% knee (n = 4), 20% foot (n = 4), 10% heel (n = 2), and 5% ankle (n = 1). The average length of treatment with NPWTi was 5.2 days (2-10). Successful wound closure within 6 weeks was achieved in 65% of the cases (n = 13). Of the closed wounds (n = 13), 54% (n = 7) were closed primarily and 46% (n = 6) were closed by secondary procedures (skin graft or skin flap). NPWTi is still considered a novel technique that can be used in the management of complex wounds, and the goal of this prospective study is to report our experience with NPWTi in the management of complex infected orthopaedic lower limb wounds. Randomised control studies with optimally matched wounds comparing NPWTi to the conventional methods of treatment are warranted.
C1 [Elhessy, Ahmed H.; Chaudhry, Arif R.; Hammouda, Ahmed, I; Giacobbe, Shawn D.; Gesheff, Martin G.; Conway, Janet D.] Sinai Hosp Baltimore, Int Ctr Limb Lengthening, Rubin Inst Adv Orthoped, Schoeneman Bldg,2nd Floor,2401 West Belvedere Ave, Baltimore, MD 21215 USA.
   [Chaudhry, Arif R.] Omni Cosmet, Wayzata, MN USA.
   [Hammouda, Ahmed, I] Al Azhar Univ Hosp, Dept Orthopaed Surg, Cairo, Egypt.
C3 Sinai Hospital of Baltimore; Egyptian Knowledge Bank (EKB); Al Azhar
   University; Al Azhar University hospital
RP Conway, JD (通讯作者)，Sinai Hosp Baltimore, Int Ctr Limb Lengthening, Rubin Inst Adv Orthoped, Schoeneman Bldg,2nd Floor,2401 West Belvedere Ave, Baltimore, MD 21215 USA.
EM jconway@lifebridgehealth.org
OI Conway, Janet/0000-0001-5694-3081; Elhessy, Ahmed/0000-0003-4556-2325
FU Investigator-Initiated Research Grant from KCI USA, Inc.
FX This study was supported by an Investigator-Initiated Research Grant
   from KCI USA, Inc. JDC reports the following disclosures: Bonesupport
   (consultant), Smith&Nephew (consultant), Zimmer Biomet (consultant),
   Biocomposites (fellowship support), and the University of Florida
   (spouse receives royalties). The following organisations supported the
   corresponding institution's annual course (the Baltimore Limb Deformity
   Course) for orthopaedic surgeons: Biocomposites, DePuy Synthes
   Companies, MHE Coalition, Orthofix, OrthoPediatrics, Pega Medical, Smith
   & Nephew, Stryker, and Zimmer Biomet (all authors).
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   Hermans MHE, 2013, J WOUND CARE, V22, P573, DOI 10.12968/jowc.2013.22.11.573
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Lehner B, 2011, INT ORTHOP, V35, P1415, DOI 10.1007/s00264-011-1274-y
   Lessing M Christian, 2013, Eplasty, V13, pe51
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   Omar M, 2016, J WOUND CARE, V25, P475, DOI 10.12968/jowc.2016.25.8.475
NR 14
TC 8
Z9 8
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2021
VL 18
IS 6
BP 902
EP 908
DI 10.1111/iwj.13592
EA MAR 2021
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA XM0ZU
UT WOS:000634450800001
PM 33783102
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yane, Y
   Hida, J
   Makutani, Y
   Ushijima, H
   Yoshioka, Y
   Iwamoto, M
   Wada, T
   Daito, K
   Tokoro, T
   Ueda, K
   Kawamura, J
AF Yane, Yoshinori
   Hida, Jin-ichi
   Makutani, Yusuke
   Ushijima, Hokuto
   Yoshioka, Yasumasa
   Iwamoto, Masayoshi
   Wada, Toshiaki
   Daito, Koji
   Tokoro, Tadao
   Ueda, Kazuki
   Kawamura, Junichiro
TI The technique for less infectious and earlier healing of stoma closure
   wound: negative pressure wound therapy with instillation and dwelling
   followed by primary closure
SO BMC SURGERY
LA English
DT Article
DE Stoma closure; Surgical site infection; SSI; NPWTi-d; Delayed primary
   closure; V; A; C; VERAFLO Therapy
AB BackgroundTemporary stomas have been widely used to avoid the risk of complications such as anastomotic leakage after colorectal resection. Stoma closure is relatively easy; however, postoperative surgical site infection (SSI) may be a problem. Various methods have been used to reduce the incidence of SSI. We aimed to evaluate a new technique for stoma wound closure.MethodsWe enrolled patients who underwent stoma closure at our hospital between September 2019 and May 2020. We selected patients who lived far from our hospital and had difficulty visiting the hospital regularly and who agreed to undergo this surgical technique. We used negative pressure wound therapy with instillation and dwelling (NPWTi-d) and delayed primary closure for these patients.ResultsFour patients underwent NPWTi-d and delayed primary closure without the occurrence of SSI. The median postoperative hospital stay was 9 days (range: 7-14 days), and the median number of days to confirmation of epithelialization was 11.5 days (range: 10-16 days).ConclusionThe combined use of NPWTi-d and delayed primary closure for the stoma wound was very effective. This method may be a valuable new technique for wound management after stoma closure.
C1 [Yane, Yoshinori; Makutani, Yusuke; Ushijima, Hokuto; Yoshioka, Yasumasa; Iwamoto, Masayoshi; Wada, Toshiaki; Daito, Koji; Tokoro, Tadao; Ueda, Kazuki; Kawamura, Junichiro] Kindai Univ, Fac Med, Dept Surg, Osaka, Japan.
   [Hida, Jin-ichi] Kindai Univ, Dept Gastroenterol Surg, Nara Hosp, Nara, Japan.
C3 Kindai University (Kinki University); Kindai University (Kinki
   University)
RP Yane, Y (通讯作者)，Kindai Univ, Fac Med, Dept Surg, Osaka, Japan.
EM yaneyoshinori0127@med.kindai.ac.jp
RI Ueda, Kazuki/AAB-6618-2022; Kawamura, Junichiro/H-9205-2019; 幕谷,
   悠介/IAP-9683-2023
OI Kawamura, Junichiro/0000-0001-5404-5317; 
FU Grants-in-Aid for Scientific Research [21H04958] Funding Source: KAKEN
CR Amamo K, 2019, SURG TODAY, V49, P231, DOI 10.1007/s00595-018-1729-5
   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
   Chu DI, 2015, J GASTROINTEST SURG, V19, P327, DOI 10.1007/s11605-014-2649-3
   Fernandez R, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003861.pub2
   Fluieraru S, 2013, J WOUND CARE, V22, P293, DOI 10.12968/jowc.2013.22.6.293
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   Kim S, 2020, TRIALS, V21, DOI 10.1186/s13063-019-3925-z
   Li LT, 2014, DIGEST SURG, V31, P73, DOI 10.1159/000354426
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   Sharma A, 2013, COLORECTAL DIS, V15, P458, DOI 10.1111/codi.12029
   Uchino M, 2016, DIGEST SURG, V33, P449, DOI 10.1159/000446550
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   Yoon SI, 2015, ANN COLOPROCTOL, V31, P29, DOI 10.3393/ac.2015.31.1.29
NR 21
TC 6
Z9 8
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD MAR 22
PY 2021
VL 21
IS 1
AR 157
DI 10.1186/s12893-021-01109-2
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RF3WO
UT WOS:000634772000002
PM 33752660
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mo, R
   Ma, ZJ
   Chen, C
   Meng, XY
   Tan, Q
AF Mo, Ran
   Ma, Zhouji
   Chen, Chen
   Meng, Xueyong
   Tan, Qian
TI Short- and long-term efficacy of negative-pressure wound therapy in
   split-thickness skin grafts: a retrospective study
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE Negative-pressure wound therapy (NPWT); skin graft; survival rate; scar
ID VACUUM-ASSISTED CLOSURE; DONOR SITE; MANAGEMENT; RECONSTRUCTION;
   MULTICENTER; TIE
AB Background: Graft fixation is essential for the successful survival of skin grafts. Negative-pressure wound therapy (NPWT) can be utilized for fixing a skin graft, ensuring adhesion of the graft with continuous and uniform pressure. However, the reported short- and long-term efficacy of NPWT in split-thickness skin grafts (STSGs) is inconsistent, with few studies on the long-term efficacy (scar quality). To clarify the appropriate methods of skin graft fixation, we conducted a single-center retrospective study on the short-and long-term effects of skin grafting using different fixation methods.
   Methods: This study retrospectively analyzed patients who underwent STSG from December 2010 to June 2019. The patients were divided into two groups based on the skin graft-fixing method: an NPWT group and a conventional mechanical fixation group. Medical data including age, sex, underlying diseases, wound etiology, recipient site, surgical methods, surgical outcomes, postoperative complications, and follow-up data (Vancouver Scar Scale score and Patient and Observer Scar Assessment Scale score) were analyzed.
   Results: A total of 392 cases were ultimately included in the analysis. Among them, 218 cases were fixed with NPWT for skin grafting and 174 with conventional mechanical fixation. No significant differences in baseline data were noted between the two groups. The total graft survival rate in the NPWT group was higher than that in the conventional mechanical fixation group (86.7% vs. 74.1%, P=0.002). Moreover, the infection rate in the NPWT group was lower than that in the conventional mechanical fixation group (5.5% vs. 13.2%, P=0.008). In terms of scar quality, no significant difference was observed, except for in the hand. Overall, the scar surface regularity was better in the NPWT group than in the control group. (P=0.019 for Patient Scar Assessment Scale, P=0.025 for Observer Scar Assessment Scale).
   Conclusions: NPWT is an effective approach for fixing skin grafts. Compared with conventional mechanical fixation, NPWT can significantly improve the survival rate and reduce the infection rate of STSG. In the long-term, NPWT can also improve scar surface regularity in the hand, with an esthetic effect that is more satisfactory to clinicians and patients.
C1 [Mo, Ran; Ma, Zhouji; Tan, Qian] Nanjing Med Univ, Dept Burns & Plast Surg, Nanjing Drum Tower Hosp Clin Coll, 321 Zhongshan Rd, Nanjing 210008, Peoples R China.
   [Mo, Ran; Meng, Xueyong; Tan, Qian] Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Burns & Plast Surg,Med Sch, 321 Zhongshan Rd, Nanjing 210008, Peoples R China.
   [Chen, Chen] Nanjing Univ, Dept Nutr, Nanjing Drum Tower Hosp, Affiliated Hosp,Med Sch, Nanjing, Peoples R China.
C3 Nanjing Medical University; Nanjing University; Nanjing University
RP Tan, Q (通讯作者)，Nanjing Med Univ, Dept Burns & Plast Surg, Nanjing Drum Tower Hosp Clin Coll, 321 Zhongshan Rd, Nanjing 210008, Peoples R China.
EM smmutanqian@sina.com
RI Ma, Zhouji/ISB-4061-2023; Chen, Chen/MIQ-8826-2025
OI Ma, Zhouji/0000-0003-1267-0151; 
FU National Natural Science Foundation of China [81800241]; Postgraduate
   Research & Practice Innovation Program of Jiangsu Province
   [SJCX20_0484]; Fundamental Research Funds for the Central Universities
   [14380479]
FX This work was supported by the National Natural Science Foundation of
   China (grant number: 81800241), Postgraduate Research & Practice
   Innovation Program of Jiangsu Province (SJCX20_0484) and the Fundamental
   Research Funds for the Central Universities (14380479).
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NR 28
TC 10
Z9 12
U1 0
U2 11
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD MAR
PY 2021
VL 10
IS 3
BP 2935
EP 2947
DI 10.21037/apm-20-1806
PG 13
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA RH8MU
UT WOS:000636466300052
PM 33691438
OA gold
DA 2026-07-24
ER
PT J
AU Masters, J
   Cook, J
   Achten, J
   Costa, ML
AF Masters, J.
   Cook, J.
   Achten, J.
   Costa, M. L.
TI A feasibility study of standard dressings versus negative-pressure wound
   therapy in the treatment of adult patients having surgical incisions for
   hip fractures: the WHISH randomized controlled trial
SO BONE & JOINT JOURNAL
LA English
DT Article
ID TRAUMA EVALUATION ONE; ABRIDGED PROTOCOL; SCREW FIXATION; X-BOLT; WHITE;
   INFECTION; HEMIARTHROPLASTY; COMPLICATIONS; SURGERY; COHORT
AB Aims
   This study sought to compare the rate of deep surgical site infection (SSI), as measured by the Centers for Disease Control and Prevention (CDC) definition, after surgery for a fracture of the hip between patients treated with standard dressings and those treated with incisional negative pressure wound therapy (iNPWT). Secondary objectives included determining the rate of recruitment and willingness to participate in the trial.
   Methods
   The study was a two-arm multicentre randomized controlled feasibility trial that was embedded in the World Hip Trauma Evaluation cohort study. Any patient aged > 65 years having surgery for hip fracture at five recruitment centres in the UK was considered to be eligible. They were randomly allocated to have either a standard dressing or iNPWT after closure of the wound. The primary outcome measure was deep SSI at 30 and 90 days, diagnosed according to the CDC criteria. Secondary outcomes were: rate of recruitment; further surgery within 120 days; health-related quality of life (HRQoL) using the EuroQol five-level five-dimension questionnaire (EQ-5D-5L); and related complications within 120 days as well as mobility and residential status at this time.
   Results
   A total of 462 valid randomizations were carried out (232 and 230 in the standard dressing and iNPWT groups, respectively). In the standard dressing group, 14 of 218 patients (6.4%) developed deep SSI. In the iNPWT group, four of 214 patients (1.9%) developed deep SSI. This gives a total rate of SSI of 4.2% (95% confidence interval (CI) 2.7% to 6.5%). Patients and surgeons were willing to participate in the study with 462 patients being recruited from a possible 749 (62.3%).
   Conclusion
   The rate of deep SSI 30 days after surgery for a fracture of the hip was 4%, which makes a study comparing the clinical effectiveness of standard dressings and iNPWT feasible.
C1 [Masters, J.; Cook, J.; Achten, J.; Costa, M. L.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
C3 University of Oxford
RP Masters, J (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
EM james.masters@ndorms.ox.ac.uk
RI Masters, James/U-8764-2019; Cook, Jonathan/D-3648-2015; Achten,
   Juul/KUD-8515-2024
OI Masters, James/0000-0001-9663-8858; Cook, Jonathan/0000-0002-4156-6989;
   Costa, Matthew/0000-0003-3644-1388; Achten, Juul/0000-0002-8857-5743
FU Royal College of Surgeons of England/Dunhill Medical Trust research
   training fellowship; Smith Nephew; NIHR Oxford Biomedical Research
   Centre
FX J. Masters and J. Cook report institutional grants (paid to University
   of Oxford) from the Royal College of Surgeons of England/Dunhill Medical
   Trust research training fellowship, Smith & Nephew (device supply), and
   the NIHR Oxford Biomedical Research Centre (research infrastructure
   support), all related to this study. M. Costa reports institutional
   research grant funding (paid to University of Oxford) from the National
   Institute for Health Research (NIHR), the European Union (EU), the Royal
   College of Surgeons (RCS) England, and Smith & Nephew, not related to
   this study.
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   [Anonymous], 2018, National Hip Fracture Database Annual Report
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   Sims AL, 2016, BONE JOINT RES, V5, P18, DOI 10.1302/2046-3758.51.2000473
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NR 32
TC 18
Z9 20
U1 0
U2 6
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD APR
PY 2021
VL 103B
IS 4
BP 755
EP 761
DI 10.1302/0301-620X.103B4.BJJ-2020-1603.R1
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA RI5GM
UT WOS:000636935700023
PM 33789474
DA 2026-07-24
ER
PT J
AU Chatterjee, R
   Riddle, TM
   Poskarbiewicz, MK
   Babcock, GF
AF Chatterjee, Ranjit
   Riddle, Tara M.
   Poskarbiewicz, Melisa K.
   Babcock, George F.
TI A Novel Approach to Negative Pressure Wound Therapy: Use of High Suction
   Capillary Device to Improve Wound Healing
SO MILITARY MEDICINE
LA English
DT Article
AB Introduction:
   Negative Pressure Wound Therapy (NPWT) is a procedure used for nonhealing wounds. In NPWT, a special sealed dressing of large cell foam (>400 mu m) or gauze is connected to a pump. Most commonly, negative pressures between -10 and -125 millimeters of mercury (mm Hg) are used. The mechanism of healing is unknown but maybe attributable to removal of the exudate and bacteria, and the stimulation of tissue repair through microdeformation. Reticulated foams with micron-size open cells, Capillary Suction Devices (CSD; 100 to 5 mu m) exert capillary suction between 10 and 70 mm of Hg with a multilayered foam dressing.
   Materials and Methods:
   Yorkshire pigs received 5 surgical excision wounds, 3 cm(2), on each side of the back. The wounds were covered with a NPWT dressing (110 mm Hg negative pressure by a pump), CSD with capillary suctions of 30 mm Hg (CSD-30) and 70 mm Hg (CSD-70), and a conventional gauze dressing. The wounds were measured on day 2, and then every 4-5 days thereafter; the total fluid collected by the various dressing over time.
   Results:
   By post-wound day 20, the wounds treated with CSD-70 and NPWT were 100% closed while the wounds treated with CSD-30 and gauze were 65% and 45%, respectively. This indicated comparable wound closure efficacies for CSD-70 and NPWT. The average total fluid uptake measured in grams dry weight were similar for CSD-70 and NPWT, 36 and 38 g, respectively, while the values were 24 g for CSD-30 and 12 g for gauze. However, the maximum fluid uptake observed at day 2 indicated that CSD-70 and CSD 30, 24 and 14 g, respectively, were superior to NPWT and gauze 12 and 7 g, respectively.
   Conclusion:
   This data indicate comparable wound closure efficacies for CSD-70 and NPWT. It is felt that CSD is an effective, safe, and lower cost alternative to vacuum-assisted NPWT.
C1 [Chatterjee, Ranjit] Dristi LLC, Cincinnati, OH 45243 USA.
   [Riddle, Tara M.; Poskarbiewicz, Melisa K.; Babcock, George F.] Univ Cincinnati, Dept Surg, 231 Bethesda Ave, Cincinnati, OH 45267 USA.
   [Babcock, George F.] Shriners Hosp Children, Cincinnati, OH 45229 USA.
C3 University System of Ohio; University of Cincinnati
RP Chatterjee, R (通讯作者)，Dristi LLC, Cincinnati, OH 45243 USA.
RI /K-9469-2019
FU Shriners Hospitals for Children [SHCC 871000]
FX This study was supported in part by a grant from Shriners Hospitals for
   Children (#SHCC 871000).
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NR 27
TC 2
Z9 2
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN-FEB
PY 2021
VL 186
SU 1
BP 364
EP 369
DI 10.1093/milmed/usaa276
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RJ0XS
UT WOS:000637327600052
PM 33499483
OA Bronze
DA 2026-07-24
ER
PT J
AU Steinbichler, TB
   Wolfram, D
   Runge, A
   Hartl, R
   Dejaco, D
   Rauchenwald, T
   Pototschnig, C
   Riechelmann, H
   Schartinger, VH
AF Steinbichler, Teresa Bernadette
   Wolfram, Dolores
   Runge, Annette
   Hartl, Roland
   Dejaco, Daniel
   Rauchenwald, Tina
   Pototschnig, Claus
   Riechelmann, Herbert
   Schartinger, Volker Hans
TI Modified vacuum-assisted closure (EndoVAC) therapy for treatment of
   pharyngocutaneous fistula: A case series and a review of the literature
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Review
DE head and neck cancer; laryngectomy; negative&#8208; pressure wound
   therapy; radiochemotherapy; salvage surgery
AB Background Pharyngocutaneous fistula is a potential life-threatening complication following head and neck surgery. There is only limited evidence about the efficacy of vacuum-assisted closure (VAC) therapy and endoscopic vacuum-assisted closure (EndoVAC) therapy for the treatment of pharyngocutaneous fistulas.
   Methods In this article, we report on a consecutive case series of six male patients with pharyngocutaneous fistula treated with a modified outside-in EndoVAC technique. We also present a review of the current related literature.
   Results EndoVAC therapy alone was successful in five of the six patients (83.3%) with a median duration of EndoVAC therapy of 18.5 days (range: 7 to 32 days) and a median number of EndoVAC sponge changes of 4 (range: 1 to 9 changes). One patient needed additional reconstructive surgery after prior radiochemotherapy and jejunal transfer. No treatment-related complications were observed.
   Conclusion EndoVAC therapy is an easy-to-perform, safe procedure for the treatment of pharyngocutaneous fistulae.
C1 [Steinbichler, Teresa Bernadette; Runge, Annette; Hartl, Roland; Dejaco, Daniel; Pototschnig, Claus; Riechelmann, Herbert; Schartinger, Volker Hans] Med Univ Innsbruck, Dept Otorhinolaryngol Head & Neck Surg, Anichstr 35, A-6020 Innsbruck, Austria.
   [Wolfram, Dolores; Rauchenwald, Tina] Med Univ Innsbruck, Dept Plast Reconstruct & Aesthet Surg, Innsbruck, Austria.
C3 Medical University of Innsbruck; Medical University of Innsbruck
RP Schartinger, VH (通讯作者)，Med Univ Innsbruck, Dept Otorhinolaryngol Head & Neck Surg, Anichstr 35, A-6020 Innsbruck, Austria.
EM volker.schartinger@i-med.ac.at
OI Schartinger, Volker/0000-0002-5887-7644; Wolfram,
   Dolores/0000-0003-0920-7211; Steinbichler, Teresa
   Bernadette/0000-0002-2666-226X; Runge, Annette/0000-0003-1211-3996;
   Deutinger, Tina/0000-0002-7555-1582
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
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NR 31
TC 15
Z9 16
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD AUG
PY 2021
VL 43
IS 8
BP 2377
EP 2384
DI 10.1002/hed.26684
EA APR 2021
PG 8
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA TE2IF
UT WOS:000637780800001
PM 33830587
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Zha, YJ
   Hua, KH
   Gong, MQ
   Jiang, XY
AF Zha, Yejun
   Hua, Kehan
   Gong, Maoqi
   Jiang, Xieyuan
TI Chronic type C3 distal humeral fracture associated with massive bone
   defects treated by open reduction and internal fixation with iliac crest
   autografts: a case report
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Distal humeral fracture; Chronic intercondylar fracture; Bone defect;
   Open reduction and internal fixation; Iliac crest autograft
AB BackgroundChronic intercondylar fractures of the distal humerus with massive bone defects and severe comminution in the metaphysis are rare and complex injuries that are challenging for surgeons to treat, as reconstructing the triangular structure of the distal humerus is difficult and may have a severe impact on functional outcomes, especially in young patients, for whom total elbow arthroplasty is usually not a suitable option due to significant impairment in upper limb strength. Here, we report a patient in such scenario who was young and active and was treated by structural iliac bone autografting and internal fixation.Case presentationA 26-year-old male patient experienced a major car accident and was diagnosed with an open fracture (Gustilo-Anderson type IIIB) of the right distal humerus with massive bone defects and severe intra-articular involvement, without neurovascular injuries or other associated injuries. Surgical debridement, negative pressure vacuum sealing drainage, and immobilization by braces were initially performed, and the wound was closed after 15days. When the wound had finally healed and the soft tissue was in good condition without infection or effusion 45days later, this young and active patient was diagnosed with a chronic type C3 distal humeral fracture associated with massive bone defects at the supracondylar level in both columns and severe comminution at the trochlear groove. We performed surgical debridement and arthrolysis around the fracture site, and then, we successfully reconstructed the triangular structure of the distal humerus using structural iliac crest autografts in both columns as well as in the defective trochlear groove. Finally, internal fixation via a parallel double-plate configuration was performed. Over a follow-up period of 3years, the patient achieved almost full recovery of range of motion and an excellent functional score, without minor or major postoperative complications.ConclusionIn this study, we proposed a surgical reconstruction strategy for complex chronic distal humeral fractures associated with massive bone defects and severe articular involvement in young and active patients using metaphyseal shortening and structural iliac crest bone autografting together with open reduction and internal fixation via a parallel configuration.
C1 [Zha, Yejun; Hua, Kehan; Gong, Maoqi; Jiang, Xieyuan] Beijing Jishuitan Hosp, Dept Orthoped Trauma, 31 Xinjiekou East St, Beijing 100035, Peoples R China.
RP Jiang, XY (通讯作者)，Beijing Jishuitan Hosp, Dept Orthoped Trauma, 31 Xinjiekou East St, Beijing 100035, Peoples R China.
EM jxy0845@sina.com
RI ZHA, Yejun/KCK-2028-2024
FU Beijing Natural Science Foundation [L192049]; Beijing Municipal Health
   Commission [BMHC2019-9]; Ministry of Science and Technology of the
   People's republic of China [2017YFC0110603]
FX 1. Funder: Beijing Natural Science Foundation Grant name (number):
   Beijing Natural Science Foundation (L192049). 2. Funder: Beijing
   municipal health commission Grant name (number): Beijing Municipal
   Health Commission (BMHC2019-9). 3. Funder: Ministry of Science and
   Technology of the People's republic of China Grant name (number):
   National Key R&D Program of China (2017YFC0110603).
CR Barco R, 2017, J BONE JOINT SURG AM, V99, P1524, DOI 10.2106/JBJS.16.01222
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NR 23
TC 2
Z9 5
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD APR 7
PY 2021
VL 22
IS 1
AR 338
DI 10.1186/s12891-021-04199-4
PG 8
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA RK0NR
UT WOS:000638002700004
PM 33827519
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Bingoel, AS
   Krezdorn, N
   Kaltenborn, A
   Dastagir, K
   Jokuszies, A
   Mett, TR
   Vogt, PM
AF Bingoel, Alperen S.
   Krezdorn, Nicco
   Kaltenborn, Alexander
   Dastagir, Khaled
   Jokuszies, Andreas
   Mett, Tobias R.
   Vogt, Peter M.
TI The surgical approach to Pyoderma gangrenosum: A retrospective
   monocenter study
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE chronic wounds; negative pressure wound therapy; Pyoderma gangrenosum;
   skin grafting; wound healing
AB Pyoderma gangrenosum is a diagnosis of exclusion. It occurs rarely and is frequently misdiagnosed. It can result in severe tissue loss, particularly in surgical units with little experience. Nevertheless, surgical treatment might be necessary for reconstruction, once the progression of these wounds is controlled. We aimed to characterize medical findings in Pyoderma patients with extensive defects to assess the surgical procedures and their outcome. A retrospective study was conducted at our centre over an 18-year period. Inclusion criteria were the diagnosis of Pyoderma gangrenosum and at least one surgical intervention. Descriptive statistics were used to analyse the data. Sixteen patients were included. The mean size of the lesions was noted with 12 x 8 cm. Surgical procedures comprised debridements/necrectomies, allograft conditioning, negative pressure wound therapy, skin grafts, and microvascular free flaps. Seven patients were discharged with healed wounds, six with minor wound healing disturbances. Three patients succumbed to their underlying diseases. Drug-based therapy can stop the progress of Pyoderma, but severe tissue loss can be a persistent problem. According to our data, reconstructive-surgical treatments (debridement, autologous and allogenous skin transplantation and microvascular free flaps) act as an integral component of the therapy and can be safe options for selected patients. Furthermore, we provide an algorithm that we follow at our department in severe cases.
C1 [Bingoel, Alperen S.; Krezdorn, Nicco; Dastagir, Khaled; Jokuszies, Andreas; Mett, Tobias R.; Vogt, Peter M.] Hannover Med Sch, Burn Ctr, Dept Plast Aesthet Hand & Reconstruct Surg, Hannover, Germany.
   [Kaltenborn, Alexander] Armed Forces Hosp Westerstede, Dept Trauma & Orthoped Surg Plast Hand & Reconstr, Westerstede, Germany.
C3 Hannover Medical School
RP Bingoel, AS (通讯作者)，Hannover Med Sch, Dept Plast Aesthet Hand & Reconstruct Surg, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM bingoel.alperen@mh-hannover.de
RI Vogt, Peter/AAL-1332-2020; Krezdorn, Nicco/AAP-6266-2021; Bingoel,
   Alperen Sabri/MHQ-0362-2025
OI Krezdorn, Nicco/0000-0003-2662-6290; Bingoel, Alperen
   Sabri/0000-0003-4057-0318
FU Projekt DEAL
FX The authors like to thank all of the patients for their excellent
   cooperation. Special thanks go to Nora Schaumann and Hinrich Freitag,
   Institute of Pathology of Hannover Medical School, for providing the
   histopathological images. Open access funding enabled and organized by
   Projekt DEAL.
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NR 40
TC 11
Z9 14
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY
PY 2021
VL 29
IS 3
BP 478
EP 485
DI 10.1111/wrr.12918
EA APR 2021
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA SC5OP
UT WOS:000638268300001
PM 33835625
OA hybrid
DA 2026-07-24
ER
PT J
AU Roos, E
   Douissard, J
   Abbassi, Z
   Buchs, NC
   Tosoz, C
   Ris, F
   Meyer, J
AF Roos, Elfin
   Douissard, Jonathan
   Abbassi, Ziad
   Buchs, Nicolas C.
   Tosoz, Christian
   Ris, Frederic
   Meyer, Jeremy
TI Prophylactic negative-pressure wound therapy for prevention of surgical
   site infection in abdominal surgery: a nationwide cross-sectional survey
SO UPDATES IN SURGERY
LA English
DT Article
DE Negative therapy; Negative-pressure therapy; PREVENA; PICO
ID ABDOMINOPERINEAL RESECTION; INCISIONAL HERNIA; RECTAL-CANCER;
   RISK-FACTORS; PERINEAL; CLOSURE; IMPACT
AB Our objective was to determine current practice in Switzerland regarding the use of pNPWT in abdominal surgery. An online survey was carried out to evaluate the use of pNPWT among abdominal surgeons in Switzerland. One hundred and ten participants replied to the survey from 16.12.2019 to 15.01.2020. Eleven were excluded, leaving 99 responders for analysis. Seventy participants (70.7%) were using pNPWT, 3 (3%) have stopped using it and 26 (26.3%) have never used it. pNPWT was used on midline laparotomy by 63 responders (90%), closed stoma wounds by 21 (30%), closed perineal wounds by 20 (28.6%), Pfannenstiel incisions by 18 (23.7%), groin incisions by 16 (22.9%), subcostal incisions by 13 (18.6%), Mc Burney incisions by 3 (4.3%) and other incisions by 18 (25.7%). Forty-eight participants (68.6%) used pNPWT on less than 10% of patients, 14 (20%) on 10-25% of patients, six (8.6%) on 25-50% of patients and two (2.9%) on 75-100% of patients. Suggestions for improvement to pNPWT were: better sealing, recyclable system, better adaptation to the perineum, smaller device, reduced cost and possibility to check the surgical wound through the dressing. In conclusion, pNPWT is widely used among Swiss surgeons, mostly on midline incisions. However, most of them apply pNPWT on a small proportion of patients only. Suggestions for improvement were a better sealing for complex wounds, reduced cost and possibility to check the wound during the therapy.
C1 [Roos, Elfin] Karolinska Inst, Dept Global Publ Hlth, S-17177 Stockholm, Sweden.
   [Douissard, Jonathan; Abbassi, Ziad; Buchs, Nicolas C.; Tosoz, Christian; Ris, Frederic; Meyer, Jeremy] Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Douissard, Jonathan; Abbassi, Ziad; Buchs, Nicolas C.; Tosoz, Christian; Ris, Frederic; Meyer, Jeremy] Univ Geneva, Med Sch, CH-1205 Geneva, Switzerland.
   [Roos, Elfin] Linkoping Univ, Cty Council Ostergotland, Linkoping, Sweden.
C3 Karolinska Institutet; University of Geneva; University of Geneva; City
   Council Ostergotland; Linkoping University
RP Meyer, J (通讯作者)，Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.; Meyer, J (通讯作者)，Univ Geneva, Med Sch, CH-1205 Geneva, Switzerland.
EM jeremy.meyer@hcuge.ch
RI Douissard, Jonathan/AEJ-4252-2022; Ris, Frederic/H-7030-2019; Meyer,
   Jeremy/AAP-3367-2020; Abbassi, Ziad/HZL-6239-2023
OI Douissard, Jonathan/0000-0002-3931-3157; Ris,
   Frederic/0000-0001-7421-6101; Meyer, Jeremy/0000-0003-3381-9146;
   Abbassi, Ziad/0000-0002-4130-5084
FU Universite de Geneve
FX Open Access funding provided by Universite de Geneve.
CR Allegranzi Benedetta, 2016, Lancet Infect Dis, V16, pe288, DOI 10.1016/S1473-3099(16)30402-9
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   Roos E, ANN SURG
   Sahebally SM, 2018, JAMA SURG, V153, DOI 10.1001/jamasurg.2018.3467
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   Takahashi Y, 2018, CANCER SCI, V109, P1363
   van der Valk MJM, 2017, ADV WOUND CARE, V6, P425, DOI 10.1089/wound.2017.0749
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
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NR 21
TC 1
Z9 2
U1 0
U2 3
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD OCT
PY 2021
VL 73
IS 5
BP 1983
EP 1988
DI 10.1007/s13304-021-01017-3
EA APR 2021
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WE4VW
UT WOS:000638808700001
PM 33837948
OA Green Published, Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Zhang, P
   Tao, FL
   Li, QH
   Zhou, DS
   Liu, FX
AF Zhang, Peng
   Tao, Fu-Lin
   Li, Qing-Hu
   Zhou, Dong-Sheng
   Liu, Fan-Xiao
TI Salvage of vascular graft infections via vacuum sealing drainage
   and rectus femoris muscle flap transposition: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Vascular graft; Infection; Muscle flap transposition; Rectus femoris
   muscle flap; Vacuum sealing drainage; Case report; Trauma
AB BACKGROUND
   The management of vascular graft infections continues to be a significant challenge in a clinical situation. The aim of this report is to illustrate the novel vacuum sealing drainage (VSD) technique and rectus femoris muscle flap transposition for vascular graft infections, and to evaluate the prospective of future testing of this surgical procedure.
   CASE SUMMARY
   We report the case of a 32-year-old male patient, who presented a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft exposure. Using the VSD and muscle flap trans-position, the groin wound and vascular graft infection were finally treated successfully.
   CONCLUSION
   Our case report highlights that VSD technique and rectus femoris muscle flap transposition could be considered in patients presenting with a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft exposure, especially in consideration of treatable conditions.
C1 [Zhang, Peng; Tao, Fu-Lin; Li, Qing-Hu; Zhou, Dong-Sheng; Liu, Fan-Xiao] Shandong First Med Univ, Dept Orthopaed, Shandong Prov Hosp, 324 Qingwuweigi Rd, Jinan 250021, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical Sciences
RP Liu, FX (通讯作者)，Shandong First Med Univ, Dept Orthopaed, Shandong Prov Hosp, 324 Qingwuweigi Rd, Jinan 250021, Shandong, Peoples R China.
EM woshi631@126.com
RI Liu, Fanxiao/U-1513-2019
FU Shandong Provincial Natural Science Foundation [ZR2013HM069]; Shandong
   Key RD Program [2017GSF218089]; China Scholarship Council [201808080126]
FX Supported by Shandong Provincial Natural Science Foundation, No.
   ZR2013HM069; Shandong Key R&D Program, No. 2017GSF218089; and China
   Scholarship Council, No. 201808080126.
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NR 18
TC 2
Z9 4
U1 0
U2 4
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD APR 6
PY 2021
VL 9
IS 10
BP 2296
EP 2301
DI 10.12998/wjcc.v9.i10.2296
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RM1UO
UT WOS:000639445700015
PM 33869606
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Almansa-Saura, S
   Lopez-Lopez, V
   Eshmuminov, D
   Schneider, M
   Castellanos-Escrig, G
   Rodriguez-Valiente, M
   Crespo, MJ
   von der Groeben, M
   Lehmann, K
   Robles-Campos, R
AF Almansa-Saura, Sonia
   Lopez-Lopez, Victor
   Eshmuminov, Dilmurodjon
   Schneider, Marcel
   Castellanos-Escrig, Gregorio
   Rodriguez-Valiente, Monica
   Crespo, Maria Jesus
   von der Groeben, Markus
   Lehmann, Kuno
   Robles-Campos, Ricardo
TI Prophylactic Use of Negative Pressure Therapy in General Abdominal
   Surgery: A Systematic Review and Meta-Analysis
SO SURGICAL INFECTIONS
LA English
DT Review
DE general abdominal surgery; negative pressure wound therapy; surgical
   site infection
AB Background: Surgical site infections (SSIs) represent an economic burden to healthcare systems. The use of negative pressure wound therapy (NPWT) for SSI prophylaxis remains uncertain.
   Methods: A systematic literature search was conducted in Medline/PubMed, CINAHL, and Web of Science for relevant studies. The primary outcome was the evaluation of the effectiveness of NPWT for prophylaxis of SSI rates in general abdominal surgery. Secondary outcomes were rates of seroma and wound dehiscence, length of hospital stay, and re-admission rates. The statistical analysis was performed with random effect models.
   Results: A total of 3,193 patients from 20 articles (six randomized controlled trials [RCT], three prospective, eight retrospective, and three ambispective studies) were analyzed. Negative pressure wound therapy was associated with decreased rate of SSIs compared with standard dressing in a pooled analysis of non-randomized studies and RCTs (0.57; 95% confidence interval [CI], -0.4 to 0.8; p < 0.001). This result, however, needs to be challenged because of a significant statistical heterogeneity of the included studies (I-2 = 71%; p < 0.01). A separate analysis of the six RCTs failed to confirm the superiority of NPWT (0.64; 95% CI, -0.4 to 1.04; p = 0.07), also disclosing significant heterogeneity. The analysis of secondary outcomes was only possible in combination of randomized and non-randomized studies because of incomplete datasets in RCTs. Re-admission rates were lower after NPWT and no difference was observed for the incidence of seroma, wound dehiscence, and length of hospital stay.
   Conclusions: Based on available evidence, the routine use of NPWT for SSI prophylaxis after laparotomy in general abdominal surgery cannot be generally recommended.
C1 [Almansa-Saura, Sonia; Lopez-Lopez, Victor; Castellanos-Escrig, Gregorio; Rodriguez-Valiente, Monica; Crespo, Maria Jesus; Robles-Campos, Ricardo] Clin & Univ Hosp Virgen Arrixaca, IMIB ARRIXACA, Dept Gen Visceral & Transplantat Surg, Murcia, Spain.
   [Eshmuminov, Dilmurodjon; Schneider, Marcel; Lehmann, Kuno] Univ Hosp Zurich, Dept Visceral Surg & Transplantat, Zurich, Switzerland.
   [von der Groeben, Markus] Hosp Muri, Dept Surg, Muri, Switzerland.
C3 Hospital Clinico Universitario Virgen de la Arrixaca; University of
   Zurich; University Zurich Hospital
RP Lopez-Lopez, V (通讯作者)，Clin & Univ Hosp Virgen Arrixaca, Dept Gen Visceral & Transplantat Surg, Ctra Madrid Cartagena S-N, Murcia 30120, Spain.
EM victorrelopez@gmail.com
RI Lehmann, Kuno/M-8504-2016; Schneider, Marcel André/AAW-9712-2020;
   Schneider, Marcel/AAW-9712-2020
OI Lehmann, Kuno/0000-0002-6177-9543; Eshmuminov,
   Dilmurodjon/0000-0002-9575-7094; Schneider, Marcel
   André/0000-0002-6723-8879; Robles, Ricardo/0000-0003-0007-562X; 
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   Lopez-Lopez V, 2020, SURG ONCOL, V33, P81, DOI 10.1016/j.suronc.2019.12.007
   Mehdorn M, 2020, ACTA CHIR BELG, V120, P250, DOI 10.1080/00015458.2019.1599180
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   Sahebally SM, 2018, JAMA SURG, V153, DOI 10.1001/jamasurg.2018.3467
   Schurtz E, 2018, AM J SURG, V215, P113, DOI 10.1016/j.amjsurg.2017.08.009
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NR 39
TC 10
Z9 10
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD OCT 1
PY 2021
VL 22
IS 8
BP 854
EP 863
DI 10.1089/sur.2020.407
EA APR 2021
PG 10
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA YK2DT
UT WOS:000639963900001
PM 33844934
DA 2026-07-24
ER
PT J
AU Gwilym, BL
   Dovell, G
   Dattani, N
   Ambler, GK
   Shalhoub, J
   Forsythe, RO
   Benson, RA
   Nandhra, S
   Preece, R
   Onida, S
   Hitchman, L
   Coughlin, P
   Saratzis, A
   Bosanquet, DC
AF Gwilym, Brenig L.
   Dovell, George
   Dattani, Nikesh
   Ambler, Graeme K.
   Shalhoub, Joseph
   Forsythe, Rachael O.
   Benson, Ruth A.
   Nandhra, Sandip
   Preece, Ryan
   Onida, Sarah
   Hitchman, Louise
   Coughlin, Patrick
   Saratzis, Athanasios
   Bosanquet, David C.
TI Systematic Review and Meta-Analysis of Wound Adjuncts for the Prevention
   of Groin Wound Surgical Site Infection in Arterial Surgery
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE Groin incisions; Surgical site infection; Vascular
ID PLATELET-RICH PLASMA; VASCULAR-SURGERY; CLINICAL-TRIAL; SKIN CLOSURE;
   THERAPY; COMPLICATIONS; GENTAMICIN; VANCOMYCIN; MANAGEMENT; REDUCTION
AB Objective: Groin incision surgical site infections (SSIs) following arterial surgery are common and are a source of considerable morbidity. This review evaluates interventions and adjuncts delivered immediately before, during, or after skin closure, to prevent SS's in patients undergoing arterial interventions involving a groin incision.
   Data sources: MEDLINE, EMBASE, and CENTRAL databases were searched.
   Review methods: This review was undertaken according to established international reporting guidelines and was registered prospectively with the International prospective register of systematic reviews (CRD42020185170). The MEDLINE, EMBASE, and CENTRAL databases were searched using pre-defined search terms without date restriction. Randomised controlled trials (RCTs) and observational studies recruiting patients with non-infected groin incisions for arterial exposure were included; SSI rates and other outcomes were captured. Interventions reported in two or more studies were subjected to meta-analysis.
   Results: The search identified 1 532 articles. Seventeen RCTs and seven observational studies, reporting on 3 747 patients undergoing 4 130 groin incisions were included. A total of seven interventions and nine outcomes were reported upon. Prophylactic closed incision negative pressure wound therapy (ciNPWT) reduced groin SSIs compared with standard dressings (odds ratio [OR] 0.34, 95% CI 0.23 - 0.51; p < .001, GRADE strength of evidence: moderate). Local antibiotics did not reduce groin SSIs (OR 0.60 95% CI 0.30 - 1.21 p = .15, GRADE strength: low). Subcuticular sutures (vs. transdermal sutures or clips) reduced groin SSI rates (OR 0.33, 95% CI 0.17 - 0.65, p = .001, GRADE strength: low). Wound drains, platelet rich plasma, fibrin glue, and silver alginate dressings did not show any significant effect on SSI rates.
   Conclusion: There is evidence that ciNPWT and subcuticular sutures reduce groin SSI in patients undergoing arterial vascular interventions involving a groin incision. Local antibiotics did not reduce groin wound SSI, although the strength of this evidence is lower. No other interventions demonstrated a significant effect.
C1 [Gwilym, Brenig L.; Bosanquet, David C.] Royal Gwent Hosp, South East Wales Vasc Network, Newport, Gwent, Wales.
   [Dovell, George; Ambler, Graeme K.] Univ Bristol, Bristol, Avon, England.
   [Dattani, Nikesh] Queen Elizabeth Hosp Birmingham, Birmingham, W Midlands, England.
   [Shalhoub, Joseph; Onida, Sarah] Imperial Coll Healthcare NHS Trust, Imperial Vasc Unit, London, England.
   [Shalhoub, Joseph; Onida, Sarah] Imperial Coll London, Acad Sect Vasc Surg, Dept Surg & Canc, London, England.
   [Forsythe, Rachael O.] Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland.
   [Benson, Ruth A.] Univ Birmingham, Birmingham, W Midlands, England.
   [Nandhra, Sandip] Newcastle Univ, Northern Vasc Ctr, Inst Populat Hlth Sci, Newcastle Upon Tyne, Tyne & Wear, England.
   [Preece, Ryan] Cheltenham Gen Hosp, Cheltenham, Glos, England.
   [Hitchman, Louise] Hull York Med Sch, Kingston Upon Hull, N Humberside, England.
   [Coughlin, Patrick] Univ Cambridge, Cardiovasc Interdisciplinary Res Ctr, Cambridge, England.
   [Saratzis, Athanasios] Univ Leicester, NIHR Leicester Biomed Res Ctr, Dept Cardiovasc Sci, Leicester, Leics, England.
C3 Royal Gwent Hospital; University of Bristol; University of Birmingham;
   Imperial College London; Imperial College London; University of
   Edinburgh; University of Birmingham; Newcastle University - UK;
   Gloucestershire Hospitals NHS Foundation Trust; Cheltenham General
   Hospital; University of Hull; University of York - UK; University of
   Cambridge; University of Leicester
RP Gwilym, BL (通讯作者)，Royal Gwent Hosp, South East Wales Vasc Network, Newport, Gwent, Wales.
EM blgwilym@gmail.com
RI Gwilym, Brenig/AAW-1697-2021; Benson, Ruth A/AFW-3137-2022; Bosanquet,
   David/AAB-1557-2022; Shalhoub, Joseph/P-2171-2014; Saratzis,
   Athanasios/LLM-4349-2024; Hitchman, Louise/KCJ-4849-2024
OI Gwilym, Brenig/0000-0002-5403-8720; Benson, Ruth A/0000-0001-5889-4391;
   Dattani, Nikesh/0000-0003-0495-1666; Dovell, George/0000-0002-2203-9446;
   Onida, Sarah/0000-0001-5926-4578; Bosanquet, David/0000-0003-2304-0489;
   Forsythe, Rachael/0000-0002-3311-9599; Nandhra,
   Sandip/0000-0002-6036-5760; Coughlin, Patrick/0000-0003-1342-1114;
   Shalhoub, Joseph/0000-0003-1011-7440; Saratzis,
   Athanasios/0000-0002-3399-094X; Ambler, Graeme/0000-0002-3024-6365;
   Preece, Ryan/0000-0002-1718-6142; 
FU National Institutes of Health Research (NIHR) [NIHR300059] Funding
   Source: National Institutes of Health Research (NIHR); National
   Institute for Health Research [CL-2014-11-001] Funding Source:
   researchfish; Department of Health [NIHR300059] Funding Source: Medline
CR Antoniou GA, 2019, J VASC SURG, V70, P1700, DOI 10.1016/j.jvs.2019.01.083
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NR 52
TC 44
Z9 47
U1 0
U2 4
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD APR
PY 2021
VL 61
IS 4
BP 636
EP 646
DI 10.1016/j.ejvs.2020.11.053
EA APR 2021
PG 11
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA RN2KJ
UT WOS:000640180600025
PM 33423912
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Wu, YJ
   Chen, L
   Wu, SK
   Yu, LY
   Chen, MM
   Wang, JN
   Chen, JJ
   Pang, QJ
AF Wu, Yaojun
   Chen, Liang
   Wu, Shaokun
   Yu, Liying
   Chen, Mimi
   Wang, Jingnan
   Chen, Jiejie
   Pang, Qingjiang
TI Application of a simple skin stretching system and negative pressure
   wound therapy in repair of complex diabetic foot wounds
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Simple skin stretching system; Negative pressure wound therapy; Diabetic
   foot wounds
ID VACUUM SEALING DRAINAGE; CLOSURE; ULCERS; MANAGEMENT; SECURE; PLASMA
AB The management of complex diabetic foot wounds with large skin defects poses a challenge for surgeons. We presented a simple skin stretching system and negative pressure wound therapy for the repair of complex diabetic foot wounds to examine the effectiveness and safety.A total of 16 patients with diabetic foot ulcers were retrospectively reviewed between January 2015 and October 2020. All patients underwent the treatment by 3 stages. In stage 2, these difficult-to-close wounds of diabetes foot were residual. This method was applied to the wounds with a median defect size of 20.42 cm(2) (range, 4.71-66.76 cm(2)).The median time for closure of complex diabetic foot wounds was 14 days ranging from 8 to 19 days. With respect to the absolute rates of reduction, it was observed with a median of 1.86 cm(2)/day, ranging from 0.29 cm(2)/day to 8.35 cm(2)/day. In accordance with the localization of the defect, the patients were divided into 3 groups: side of the foot (37.5%), dorsum of the foot (50.0%), and others (12.5%). There was no statistical difference between side of the foot and dorsum of the foot in terms of the median defect size with P = 0.069 (Kruskal-Wallis test). Otherwise, there were statistically significant differences regarding the median time and the median absolute rates (P < 0.05; Kruskal-Wallis test). No severe complications were encountered in this study.In summary, our results show that application of the simple skin stretching system and NPWT is an effective and safe approach to complex diabetic foot wounds. Nevertheless, more attention should be paid to the appropriate patient selection and intraoperative judgment to ensure wound closure and avoid undue complications.
C1 [Wu, Yaojun; Chen, Liang; Wu, Shaokun; Yu, Liying; Chen, Mimi; Wang, Jingnan; Chen, Jiejie; Pang, Qingjiang] Univ Chinese Acad Sci, Hwa Mei Hosp, Ningbo Hosp 2, Dept Orthoped, 41 Northwest St, Ningbo 315010, Zhejiang, Peoples R China.
C3 Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS
RP Chen, L (通讯作者)，Univ Chinese Acad Sci, Hwa Mei Hosp, Ningbo Hosp 2, Dept Orthoped, 41 Northwest St, Ningbo 315010, Zhejiang, Peoples R China.
EM alanchenl@aliyun.com
RI Wu, Shaokun/NXC-0398-2025
FU Natural Science Foundation of Ningbo City [2016A610146]; Medical and
   Health Science and Technology Program Foundation of Zhejiang Province
   [2020KY843, 2015KYB342]; Hwa Mei Foundation [2019HMKY10]
FX This study was supported by a grant from the Natural Science Foundation
   of Ningbo City (2016A610146), the Medical and Health Science and
   Technology Program Foundation of Zhejiang Province (2020KY843,
   2015KYB342), and Hwa Mei Foundation (2019HMKY10).
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NR 34
TC 4
Z9 7
U1 2
U2 20
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD APR 14
PY 2021
VL 16
IS 1
AR 258
DI 10.1186/s13018-021-02405-6
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA RN6ZJ
UT WOS:000640500700003
PM 33853638
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Baldawi, M
   Bogue, S
   Mandapati, R
   Cooper, J
   Rabkin, DG
   Contractor, T
AF Baldawi, Mustafa
   Bogue, Shelly
   Mandapati, Ravi
   Cooper, Joshua
   Rabkin, David G.
   Contractor, Tahmeed
TI Early modified primary closure for treatment of cardiac implantable
   electronic device pocket infections
SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
LA English
DT Article
DE cardiac implantable electronic device; length of stay; negative pressure
   wound therapy; pocket infection; primary closure; re&#8208; infection
AB Background Guidance for wound management of the vacated generator pocket in cardiac implantable electronic device (CIED) pocket infections after removal of all hardware and tissue debridement is limited. The typical surgical technique for management of a purulent wound is to allow healing by secondary intention. An alternative approach uses negative pressure wound therapy with or without delayed primary closure. While effective in managing infection, these approaches increase hospital length of stay and costs. We present our experience with a third option: modified early primary wound closure over a suction device.
   Methods All patients with CIED pocket infections who presented to our institution between September 2018 and October 2020 underwent extraction of hardware and modified primary wound closure over a negative pressure Jackson-Pratt drain. Length of hospital and postoperative stay, complications, and recurrent infections were recorded.
   Results During the study period, 14 patients underwent modified primary wound closure for CIED pocket infections. Mean length of hospital stay was 6.64 days +/- 4.01 days (standard deviation [SD]). Mean postoperative length of stay was 3.92 +/- 2.21 days (SD). Two patients (both on intravenous heparin for mechanical valve prostheses) required re-exploration for bleeding. No patients developed recurrent infection at a mean follow up of 363 +/- 245 days (SD).
   Conclusion Based on our experience, early modified primary wound closure for CIED pocket infections appears to be safe and allows for prompt discharge with no observed re-infections.
C1 [Baldawi, Mustafa; Bogue, Shelly; Rabkin, David G.] Loma Linda Univ, Med Ctr, Dept Cardiothorac Surg, Loma Linda, CA USA.
   [Mandapati, Ravi; Contractor, Tahmeed] Loma Linda Univ, Med Ctr, Div Cardiol, Loma Linda, CA USA.
   [Cooper, Joshua] Temple Univ, Sect Cardiac Electrophysiol, Lewis Katz Sch Med, Philadelphia, PA 19122 USA.
C3 Loma Linda University; Loma Linda University; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Temple University
RP Contractor, T (通讯作者)，11234 Anderson St,Schuman Pavil,SP-1617, Loma Linda, CA 92354 USA.
EM tahmeedcontractor@gmail.com
RI Rabkin, David/IYT-3118-2023
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NR 10
TC 0
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0147-8389
EI 1540-8159
J9 PACE
JI PACE-Pacing Clin. Electrophysiol.
PD MAY
PY 2021
VL 44
IS 5
BP 765
EP 772
DI 10.1111/pace.14235
EA APR 2021
PG 8
WC Cardiac & Cardiovascular Systems; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Engineering
GA RZ1GJ
UT WOS:000641075300001
PM 33813740
DA 2026-07-24
ER
PT J
AU Zheng, BY
   Xu, G
   Jiang, H
   Duan, CW
   Liu, X
AF Zheng Biyao
   Xu Gang
   Jiang Hai
   Duan Chenwang
   Liu Xuan
TI Autologous fat grafting combined with negative pressure wound therapy in
   severe diabetic foot ulcer: a case study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE autologous fat graft; diabetes; diabetic foot ulcer; dressing;
   infection; negative pressure wound therapy; ulcer; wound
AB Objective: Hard-to-heal wounds are a surgical challenge, and diabetic foot ulcers (DFUs) are one of the most common and severe varieties. Previous studies have shown that autologous fat grafting (AFG) and negative pressure wound therapy (NPWT) have the potential to promote wound healing. This case study describes how these two methods together helped in the healing of a serious DFU.
   Case history: A 65-year-old female patient had a severe DFU on her right foot, with a 30-year history of disease and renal failure. By the time symptoms were evident, regular dressing changes and antibiotic treatment were inadequate. She received surgical debridement, AFG and NPWT. Finally, as the granulation tissue covered the full wound bed, the wound was closed by split-thickness skin grafting. One month later, the DFU was fully healed with no recurrences.
   Conclusion: The application of AFG or components of adipose tissue to treat hard-to-heal wounds has been researched at both the molecular level and in clinic. In this case, we have proved the curative effect of jointly using AFG and NPWT.
C1 [Zheng Biyao; Xu Gang; Jiang Hai; Duan Chenwang; Liu Xuan] Tangshan Gongren Hosp, Dept Burns & Plast Surg, Tangshan, Peoples R China.
   [Zheng Biyao] North China Univ Sci & Technol, Grad Sch, Tangshan, Peoples R China.
C3 North China University of Science & Technology
RP Xu, G (通讯作者)，Tangshan Gongren Hosp, Dept Burns & Plast Surg, Tangshan, Peoples R China.
EM xugang65@sina.com
CR Almeida JE, 2018, J WOUND CARE, V27, pS28, DOI 10.12968/jowc.2018.27.Sup2.S28
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NR 18
TC 5
Z9 6
U1 0
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2021
VL 30
SU 4
BP S38
EP S40
DI 10.12968/jowc.2021.30.Sup4.S38
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA RO6KY
UT WOS:000641153500006
PM 33856926
DA 2026-07-24
ER
PT J
AU Gasperetti, T
   Welte, R
   Oberacher, H
   Marx, J
   Lorenz, I
   Schellongowski, P
   Staudinger, T
   Burgmann, K
   Eller, P
   Santner, T
   Griesmacher, A
   Pfisterer, H
   Eschertzhuber, S
   Aigner, M
   Joannidis, M
   Bellmann, R
AF Gasperetti, Tiziana
   Welte, Rene
   Oberacher, Herbert
   Marx, Jana
   Lorenz, Ingo
   Schellongowski, Peter
   Staudinger, Thomas
   Burgmann, Karin
   Eller, Philipp
   Santner, Tobias
   Griesmacher, Andrea
   Pfisterer, Hartwig
   Eschertzhuber, Stephan
   Aigner, Maria
   Joannidis, Michael
   Bellmann, Romuald
TI Penetration of echinocandins into wound secretion of critically ill
   patients
SO INFECTION
LA English
DT Article
DE Echinocandin antifungals; Target-site pharmacokinetics; Wound infection;
   Invasive candidiasis; Vacuum assisted closure therapy
AB Purpose Wound infections caused by Candida are life-threatening and difficult to treat. Echinocandins are highly effective against Candida species and recommended for treatment of invasive candidiasis. As penetration of echinocandins into wounds is largely unknown, we measured the concentrations of the echinocandins anidulafungin (AFG), micafungin (MFG), and caspofungin (CAS) in wound secretion (WS) and in plasma of critically ill patients. Methods We included critically ill adults with an indwelling wound drainage or undergoing vacuum-assisted closure therapy, who were treated with an echinocandin for suspected or proven invasive fungal infection. Concentrations were measured by liquid chromatography with UV (AFG and MFG) or tandem mass spectrometry detection (CAS). Results Twenty-one patients were enrolled. From eight patients, serial WS samples and simultaneous plasma samples were obtained within a dosage interval. AFG concentrations in WS amounted to < 0.025-2.25 mg/L, MFG concentrations were 0.025-2.53 mg/L, and CAS achieved concentrations of 0.18-4.04 mg/L. Concentrations in WS were significantly lower than the simultaneous plasma concentrations and below the MIC values of some relevant pathogens. Conclusion Echinocandin penetration into WS displays a high inter-individual variability. In WS of some of the patients, concentrations may be sub-therapeutic. However, the relevance of sub-therapeutic concentrations is unknown as no correlation has been established between concentration data and clinical outcome. Nevertheless, in the absence of clinical outcome studies, our data do not support the use of echinocandins at standard doses for the treatment of fungal wound infections, but underline the pivotal role of surgical debridement.
C1 [Gasperetti, Tiziana; Welte, Rene; Marx, Jana; Bellmann, Romuald] Med Univ Innsbruck, Dept Internal Med 1, Div Intens Care & Emergency Med, Clin Pharmacokinet Unit, Anichstr 35, A-6020 Innsbruck, Austria.
   [Oberacher, Herbert] Med Univ Innsbruck, Inst Legal Med, Innsbruck, Austria.
   [Oberacher, Herbert] Med Univ Innsbruck, Core Facil Metabol, Innsbruck, Austria.
   [Lorenz, Ingo] Med Univ Innsbruck, Univ Hosp Anaesthesia & Intens Care, Gen & Surg ICU, Innsbruck, Austria.
   [Schellongowski, Peter; Staudinger, Thomas; Burgmann, Karin] Med Univ Vienna, Dept Internal Med 1, Intens Care Unit, Vienna, Austria.
   [Eller, Philipp] Univ Hosp Graz, Dept Internal Med, Intens Care Unit, Graz, Austria.
   [Santner, Tobias; Griesmacher, Andrea; Pfisterer, Hartwig] Innsbruck Gen Hosp, Cent Inst Med & Chem Lab Diagnost, Innsbruck, Austria.
   [Eschertzhuber, Stephan] Univ Hosp Anaesthesia & Intens Care, Innsbruck Gen Hosp, Transplant ICU, Innsbruck, Austria.
   [Eschertzhuber, Stephan] Innsbruck Med Univ Innsbruck, Innsbruck, Austria.
   [Aigner, Maria] Med Univ Innsbruck, Inst Hyg & Med Microbiol, Innsbruck, Austria.
   [Joannidis, Michael] Med Univ Innsbruck, Dept Internal Med 1, Div Intens Care & Emergency Med, Innsbruck, Austria.
   [Eschertzhuber, Stephan] Dist Hosp Hall In Tyrol, Dept Anaesthesia & Crit Care, Hall In Tirol, Austria.
   [Aigner, Maria] INNPATH GmbH, Tirol Kliniken, Innsbruck, Austria.
C3 Medical University of Innsbruck; Medical University of Innsbruck;
   Medical University of Innsbruck; Medical University of Innsbruck;
   Medical University of Vienna; Medical University of Innsbruck; Medical
   University of Innsbruck; Medical University of Innsbruck
RP Bellmann, R (通讯作者)，Med Univ Innsbruck, Dept Internal Med 1, Div Intens Care & Emergency Med, Clin Pharmacokinet Unit, Anichstr 35, A-6020 Innsbruck, Austria.
EM romuald.bellmann@i-med.ac.at
RI Staudinger, Thomas/NYT-5567-2025; /J-3152-2012
OI Staudinger, Thomas/0000-0003-4311-4473; Bellmann,
   Romuald/0000-0003-2861-3258
FU University of Innsbruck; Medical University of Innsbruck; Austrian
   Science Fund (FWF) [KLI 565-B31]
FX Open access funding provided by University of Innsbruck and Medical
   University of Innsbruck. The study was supported by the Austrian Science
   Fund (FWF), Grant Number KLI 565-B31.
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NR 26
TC 4
Z9 4
U1 0
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8126
EI 1439-0973
J9 INFECTION
JI Infection
PD AUG
PY 2021
VL 49
IS 4
BP 747
EP 755
DI 10.1007/s15010-021-01604-x
EA APR 2021
PG 9
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA TQ1VF
UT WOS:000641624300001
PM 33877638
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Buckle, R
   Dhukani, A
   Bridges, RL
   Garcia, BC
AF Buckle, Rosemary
   Dhukani, Anum
   Bridges, Rayven L.
   Garcia, Barton C.
TI Hurricane Harvey Aftermath An Interdisciplinary Case Report on the
   Management of an Open Bimalleolar Fracture
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID CONSEQUENCES; INFECTION
AB Natural disasters, such as hurricanes and severe flooding, pose a threat of increased skin and soft-tissue infections, especially in the event of open fractures and wading through the waters. The purpose of this case study is to present a complex patient sustaining trauma resulting in an open bimalleolar fracture, multiple wounds, and exposure to a variety of water-borne pathogens during Hurricane Harvey in Houston, Texas, in 2017. He underwent multiple incision and drainage procedures, tissue cultures, and placement of antibiotic beads, with an application of external fixation to the left ankle. Several unique multidrug-resistant water-borne pathogens were identified, including Aeromonas hydrophila, Pseudomonas fluorescens/putida, and Serratia marcescens. Once the soft-tissue envelope was restored and infection cleared, a full-thickness rotational flap with tissue expansion was performed. Ultimate reconstruction was delayed several weeks and final left ankle open reduction and internal fixation was performed following antimicrobial treatment with split-thickness skin autograft and wound vacuum-assisted closure application. The patient was discharged after 28 days with no further complications. In instances such as these, all caretakers coming into contact with the patient should be aware of the potential risks of the possible infectious diseases and management to optimize the recovery following hydrologic disasters.
C1 [Buckle, Rosemary; Dhukani, Anum; Bridges, Rayven L.; Garcia, Barton C.] St Joseph Med Ctr, 1401 St Joseph Pkwy, Houston, TX 77002 USA.
RP Dhukani, A (通讯作者)，St Joseph Med Ctr, 1401 St Joseph Pkwy, Houston, TX 77002 USA.
EM adhukani@gmail.com
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NR 10
TC 1
Z9 1
U1 0
U2 3
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD MAR-APR
PY 2020
VL 110
IS 2
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA RP8KH
UT WOS:000641971500010
DA 2026-07-24
ER
PT J
AU Mueller, KB
   D'Antuono, M
   Patel, N
   Pivazyan, G
   Aulisi, EF
   Evans, KK
   Nair, MN
AF Mueller, Kyle B.
   D'Antuono, Matthew
   Patel, Nirali
   Pivazyan, Gnel
   Aulisi, Edward F.
   Evans, Karen K.
   Nair, M. Nathan
TI Effect of Incisional Negative Pressure Wound Therapy vs Standard Wound
   Dressing on the Development of Surgical Site Infection after Spinal
   Surgery: A Prospective Observational Study
SO NEUROSURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Southern-Neurosurgical-Society
CY FEB 28, 2020
CL Scottsdale, AZ
SP S0 Neurosurg Soc
DE Surgical site infection; Negative pressure therapy; Spine surgery; Wound
   healing
ID HIGH-RISK; PREVENTION; MANAGEMENT; NPWT; COMPLICATIONS; FRACTURES;
   NUTRITION; FUSION; IMPACT
AB BACKGROUND: Use of a closed-incisional negative pressure therapy (ci-NPT) dressing is an emerging strategy to reduce surgical site infections (SSIs) in spine surgery that lacks robust data.
   OBJECTIVE: To determine the impact of a ci-NPT, as compared with a standard dressing, on the development of SSIs after spine surgery.
   METHODS: This was a prospective observational study over a 2-yr period. Indications for surgery included degenerative disease, deformity, malignancy, and trauma. Exclusion criteria included anterior and lateral approaches to the spine, intraoperative durotomy, or use of minimally invasive techniques. SSIs up to 60 d following surgery were recorded.
   RESULTS: A total of 274 patients were included. SSI rate was significantly lower with ci-NPT dressing (n = 118) as compared with the standard dressing (n = 156) (3.4 vs 10.9%, P = .02). There was no statistical difference in infection rate for decompression alone procedures (4.2 vs 9.1%, P = .63), but there was a statistically significant reduction with the use of a negative-pressure dressing in cases that required instrumentation (3.2 vs 11.4%, P = .03). Patients at higher risk (instrumentation, deformity, and malignancy) had less SSIs with the use of ci-NPT, although this did not reach statistical significance. There were no complications in either group.
   CONCLUSION: SSI rates were significantly reduced with a ci-NPT dressing vs a standard dressing in patients who underwent spinal surgery. The higher cost of a ci-NPT dressing might be justified with instrumented cases, as well as with certain high-risk patient populations undergoing spine surgery, given the serious consequences of an infection.
C1 [Mueller, Kyle B.; Patel, Nirali; Pivazyan, Gnel; Nair, M. Nathan] Georgetown Univ, Dept Neurosurg, Med Ctr, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
   [D'Antuono, Matthew] Georgetown Univ, Sch Med, Washington, DC 20007 USA.
   [Aulisi, Edward F.] MedStar Washington Hosp Ctr, Dept Neurosurg, Washington, DC USA.
   [Evans, Karen K.] Georgetown Univ, Dept Plast Surg, Med Ctr, Washington, DC 20007 USA.
C3 Georgetown University; Georgetown University; MedStar Washington
   Hospital Center; Georgetown University
RP Mueller, KB (通讯作者)，Georgetown Univ, Dept Neurosurg, Med Ctr, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM kyle.mueller85@gmail.com
RI Mueller, Kyle/HSI-4288-2023; Pivayzan, Gnel/JJF-1220-2023; D'Antuono,
   Matthew/AAD-5725-2020
OI D'Antuono, Matthew/0000-0002-1837-7004
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NR 51
TC 35
Z9 41
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-396X
EI 1524-4040
J9 NEUROSURGERY
JI Neurosurgery
PD MAY
PY 2021
VL 88
IS 5
BP E445
EP E451
DI 10.1093/neuros/nyab040
EA FEB 2021
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology; Surgery
GA RQ5EQ
UT WOS:000642441000019
PM 33611587
DA 2026-07-24
ER
PT J
AU Taeger, CD
   Wallner, S
   Martini, T
   Schiltz, D
   Kehrer, A
   Prantl, L
   Biermann, N
AF Taeger, Christian D.
   Wallner, Stefan
   Martini, Teresa
   Schiltz, Daniel
   Kehrer, Andreas
   Prantl, Lukas
   Biermann, Niklas
TI Analysis of Rinsing Fluid during Negative Pressure Wound Therapy with
   Instillation: A Potential Monitoring Tool in Acute and Chronic Wound
   Treatment. A Pilot Study
SO CELLS
LA English
DT Article
DE negative pressure wound therapy with instillation; wound healing;
   cytokines
AB Background: During negative pressure wound therapy (NPWT), open wounds are draped with a nontransparent sponge, making daily wound evaluation impossible. Sometimes, late or undetected bacterial infections and postoperative bleeding result in repetitive surgery, thus prolonging inpatient time. With the introduction of additional fluid instillation (NPWTi), the wound surface is rinsed, and bacteria, proteins and biomarkers are flushed into a collecting canister, which is later discarded. Methods: The aim of this pilot study was to analyze rinsing fluid samples (0.9% sodium chloride) from the NPWTi device in patients with acute and chronic wounds. In 31 consecutive patients a standardized laboratory analysis was performed to evaluate cellular composition and potassium, phosphate, lactate dehydrooxygenase, pH and total protein levels. Results: While there was an increase in the total cellular amount and the number of polymorphonuclear cells, the number of red blood cells (RBC) decreased after surgery. Potassium and pH showed no significant changes in the first three postoperative days, whereas total protein showed an undulant and partially significant course. Conclusion: We were able to quantify cellular metabolites by analyzing the rinsing fluid of NPWTi. We propose the analysis of this material as a novel and potentially promising tool to monitor wound status without removal of the dressing. The establishment of reference values might help to improve the NPWTi therapy.
C1 [Taeger, Christian D.; Martini, Teresa; Schiltz, Daniel; Kehrer, Andreas; Prantl, Lukas; Biermann, Niklas] Univ Hosp Regensburg, Ctr Plast Hand & Reconstruct Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
   [Wallner, Stefan] Univ Hosp Regensburg, Inst Clin Chem, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
C3 University of Regensburg; University of Regensburg
RP Taeger, CD (通讯作者)，Univ Hosp Regensburg, Ctr Plast Hand & Reconstruct Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
EM christian.taeger@ukr.de; stefan.wallner@ukr.de;
   teresa.martini@stud.uni-regensburg.de; schiltz.da@gmail.com;
   andreaskehrer@gmx.de; lukas.prantl@ukr.de; niklas.biermann@ukr.de
RI ; Kehrer, Andreas/AAC-2483-2021; Schiltz, Daniel/HJP-4834-2023; prantl,
   Lukas/AAM-1848-2021
OI Wallner, Stefan/0000-0002-3365-9579; Kehrer,
   Andreas/0000-0001-9472-7662; Schiltz, Daniel/0000-0003-1096-9336;
   prantl, Lukas/0000-0003-2454-2499
FU Manfred Roth Stiftung
FX The Manfred Roth Stiftung funded this research. The funders had no role
   in the design of the study; in the collection, analyses, or
   interpretation of data; in the writing of the manuscript; or in the
   decision to publish the results.
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NR 27
TC 6
Z9 6
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD APR
PY 2021
VL 10
IS 4
AR 732
DI 10.3390/cells10040732
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RR1MZ
UT WOS:000642872200001
PM 33810232
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gao, JR
   Wang, YY
   Song, JY
   Li, Z
   Ren, JN
   Wang, PG
AF Gao, Junru
   Wang, Yunyun
   Song, Jingyu
   Li, Ze
   Ren, Jianan
   Wang, Peige
TI Negative pressure wound therapy for surgical site infections: A
   systematic review and meta-analysis
SO JOURNAL OF ADVANCED NURSING
LA English
DT Review
DE advanced antimicrobial dressings; adverse event; closed suction
   irrigation system; continues irrigation suction systems; negative
   pressure wound therapy; nursing; surgical site infection; treatment;
   vacuum&#8208; assisted closure; wound healing
ID MANAGEMENT; CLOSURE; SURGERY; INTERVENTIONS; IRRIGATION; GUIDELINES;
   CONSENSUS; ALCOHOL; QUALITY; GROIN
AB Objective Negative pressure wound therapy is one of the most common treatments for infected wounds. The aim of this meta-analysis was to compare the efficacy of negative pressure wound therapy with conventional treatment methods in the treatment of surgical site infection.
   Design This study is registered with International Prospective Register of Systematic Reviews.
   Data Sources The Pubmed, Embase and the Cochrane Central Register of Controlled Trials databases were searched.
   Methods The systematic review was searched by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method. All trials reporting the use of negative pressure wound therapy for surgical site infection treatment were included regardless of surgery type. The primary outcome measure was wound healing. Secondary outcomes were length of hospital stay, medical costs, adverse events, and reoperation rates. Results are presented with 95% confidence intervals and report estimates as odds ratios. Heterogeneity was determined through the I-2 test, with I-2 > 50% indicating substantial heterogeneity and p We identified 13 eligible trial comparisons, of which 2 were randomized controlled trials and 11 cohort study. Negative pressure wound therapy in surgical site infection (SSI) patients significantly increased wound healing rate, accelerated wound healing time, increased daily wound healing area, reduced hospital stay, and reduced adverse events. However, negative pressure wound therapy was associated with increased medical costs.
   Conclusion Negative pressure wound therapy may be more effective for the treatment of surgical site infection relative to conventional debridement, dressings and other treatments. However, further high-quality randomized controlled trials are needed to determine the most optimal application of negative pressure wound therapy.
   Impact.
   Negative pressure wound therapy is the best treatment strategy for surgical site infection. This study can improve medical practitioners' awareness of negative pressure wound therapy for surgical site infection, promoting the development of relevant randomized controlled trials.
C1 [Gao, Junru; Wang, Yunyun; Song, Jingyu; Li, Ze; Ren, Jianan; Wang, Peige] Qingdao Univ, Affiliated Hosp, Dept Emergency Surg, 16 Jiangsu Rd, Qingdao 266000, Peoples R China.
   [Ren, Jianan] Southeast Univ, Jinling Hosp, Dept Surg, Lab Trauma & Surg Infect, Nanjing, Peoples R China.
C3 Qingdao University; Southeast University - China
RP Li, Z; Wang, PG (通讯作者)，Qingdao Univ, Affiliated Hosp, Dept Emergency Surg, 16 Jiangsu Rd, Qingdao 266000, Peoples R China.
EM 2018025944@qdu.edu.cn; wpgzyz@163.com
RI ze, li/AAJ-4308-2020; Wang, Yunyun/HJG-6977-2022
OI ze, li/0000-0002-2818-4396; 
FU Taishan Scholar Foundation of Shandong Province [2018092901]
FX This study is funded by Taishan Scholar Foundation of Shandong Province
   (Grant 2018092901).
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NR 41
TC 50
Z9 59
U1 2
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-2402
EI 1365-2648
J9 J ADV NURS
JI J. Adv. Nurs.
PD OCT
PY 2021
VL 77
IS 10
BP 3980
EP 3990
DI 10.1111/jan.14876
EA APR 2021
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA UR5YO
UT WOS:000644551500001
PM 33905552
DA 2026-07-24
ER
PT J
AU Liu, TY
   Jiang, LL
   Li, JS
   Sun, J
   Li, HM
   Gao, JY
   Li, SS
   Li, J
   Zhao, HD
AF Liu, Taiyuan
   Jiang, Lili
   Li, Jiasi
   Sun, Jie
   Li, Haomeng
   Gao, Jiyue
   Li, Sushan
   Li, Jun
   Zhao, Haidong
TI A huge malignant phyllodes tumor of the breast with osteoclast-like
   giant cells: a case report
SO GLAND SURGERY
LA English
DT Article
DE Malignant phyllodes tumor (PT); osteoclast-like giant cell (OLGC);
   breast; mastectomy; case report
ID UNDIFFERENTIATED CARCINOMA
AB The malignant phyllodes tumor (PT) of the breasts is a rare type of fibroepithelial neoplasm. Osteoclast-like giant cells (OLGCs) exist in many types of tumors. But malignant PTs with OLGCs were rarely reported. Here, we presented a case of a 49-year-old woman who had a 23 cm x21 cm x6 cm mass which was growing for 2 years in her left breast. The patient had moderate anemia due to the hemorrhage and exudation on the surface of the tumor. The imaging examinations such as PET-CT found no lymphatic involvement and distant metastasis. We performed mastectomy with a 2 cm surgical margin and free skin flap transplantation to restore the big wound. The vacuum assisted closure (VAC) system was used to promote wound healing. Histological examination of the surgical specimen showed atypical spindle-like stroma cells, marked nuclear pleomorphism, focal necrosis, and mitotic activity. Typical leaf-like architectures of PTs were observed in some regions. OLGCs were found in many sections of the tumor with a number of vascular proliferations. The final diagnosis was malignant PT with OLGCs. After a three-month follow-up, no local recurrence or metastasis was found. Autogenous skin grafts with VAC are available for large area skin defect after excising a huge breast tumor. The presence of OLGCs in malignant tumors may be related to necrosis and hemorrhage of the tumor. These findings also provide opportunities for understanding the mechanisms of tumor formation and development.
C1 [Liu, Taiyuan; Jiang, Lili; Li, Jiasi; Sun, Jie; Li, Haomeng; Gao, Jiyue; Li, Jun; Zhao, Haidong] Dalian Med Univ, Affiliated Hosp 2, Dept Breast Surg, 467 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China.
   [Li, Sushan] Dalian Med Univ, Affiliated Hosp 2, Dept Dermatol, Dalian, Peoples R China.
C3 Dalian Medical University; Dalian Medical University
RP Li, J; Zhao, HD (通讯作者)，Dalian Med Univ, Affiliated Hosp 2, Dept Breast Surg, 467 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China.
EM dyeylj@hotmail.com; z.hddl@hotmail.com
RI Li, Jiasi/ODM-2065-2025; Jiang, Lili/IVV-5296-2023; Li,
   Haomeng/MXK-1990-2025
CR Chang HY, 2020, J CLIN PATHOL, V73, P51, DOI 10.1136/jclinpath-2019-206208
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NR 19
TC 5
Z9 6
U1 1
U2 11
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2227-684X
EI 2227-8575
J9 GLAND SURG
JI Gland Surg.
PD APR
PY 2021
VL 10
IS 4
BP 1508
EP 1514
DI 10.21037/gs-20-845
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RT7WG
UT WOS:000644667600023
PM 33968702
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Dorth, D
   Königs, I
   Elrod, J
   Ghadban, T
   Reinshagen, K
   Boettcher, M
AF Dorth, Deborah
   Koenigs, Ingo
   Elrod, Julia
   Ghadban, Tarik
   Reinshagen, Konrad
   Boettcher, Michael
TI Combination of Side-Swing Flap With Negative-Pressure Wound Therapy Is
   Superior to Open Excision or Flap Alone in Children With Pilonidal
   Sinus-But at What Cost?
SO FRONTIERS IN PEDIATRICS
LA English
DT Article
DE pilonidal sinus; negative-pressure wound therapy; NPWT; open excision;
   side-swing flap
AB Background: Pilonidal sinus (PS) disease frequently occurs in adolescents and young adults, and in many cases involves wide excision or local flaps as treatment. These treatments are associated with a significant recurrence rate, a long healing time, and thus absence from school or work. The hybrid technique, which is a combination of side-swing plasty with negative-pressure wound therapy (NPWT) may improve these outcomes. The aim of the study was to compare the latter with other current methods.
   Methods: Children presenting with a pilonidal sinus to two referral centers for pediatric surgery from January 2017 till June 2019 and subsequent (1) slide-swing plasty, (2) open excision, or (3) slide-swing plasty in combination with NPWT were included in this retrospective study. Type of therapy, number of interventions, duration of hospitalization, complications, and recurrence rate were recorded. In addition, data was retrieved from the national diagnosis-related group for inpatient statistics, for all patients who underwent surgery for pilonidal sinus in 2015 and 2016.
   Results: In total, 85 children were included, with a mean age of 15 years and a near equal gender distribution (53% female). The minimum follow-up was 1 year. In 56% open resection was performed, while 18% underwent a slide-swing plasty and 26% a slide-swing plasty in combination with NPWT. While the hybrid technique was superior regarding recurrence rate in comparison to open excision (24 vs. 5%, p = 0.047), it had significantly longer hospital stay [17.41 (15.63) vs. 3.65 (1.68) days, p < 0.001] and number of interventions [4.14 (4.07) vs. 1.04 (0.29), p < 0.001].
   Conclusions: Management of PS disease using slide-swing plasty in combination with NPWT is an effective treatment and is associated with low recurrence rate and minimal morbidity. However, this type of treatment is accompanied by an elongated hospitalization time and more frequent interventions. A diligent case by case evaluation and thorough patient counseling is thus necessary when choosing the right technique for the treatment of PS disease.
C1 [Dorth, Deborah; Koenigs, Ingo; Elrod, Julia; Reinshagen, Konrad; Boettcher, Michael] Univ Med Ctr Hamburg Eppendorf, Dept Pediat Surg, Hamburg, Germany.
   [Ghadban, Tarik] Univ Med Ctr Hamburg Eppendorf, Dept Gen Visceral & Thorac Surg, Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf
RP Boettcher, M (通讯作者)，Univ Med Ctr Hamburg Eppendorf, Dept Pediat Surg, Hamburg, Germany.
EM m.boettcher@uke.de
RI Boettcher, Michael/P-6128-2018
OI Boettcher, Michael/0000-0003-4972-9866
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NR 23
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U1 0
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PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2360
J9 FRONT PEDIATR
JI Front. Pediatr.
PD APR 14
PY 2021
VL 9
AR 595684
DI 10.3389/fped.2021.595684
PG 5
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA RT8HL
UT WOS:000644696800001
PM 33937143
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rasheed, H
   Diab, K
   Singh, T
   Chauhan, Y
   Haddad, P
   Zubair, MM
   Vowels, T
   Androas, E
   Rojo, M
   Auyang, P
   McFall, R
   Gomez, LF
   Mohamed, A
   Peden, E
   Rahimi, M
AF Rasheed, Haroon
   Diab, Kaled
   Singh, Tarundeep
   Chauhan, Yusuf
   Haddad, Paul
   Zubair, M. Mujeeb
   Vowels, Travis
   Androas, Edward
   Rojo, Manuel
   Auyang, Phillip
   McFall, Ross
   Gomez, Luis Felipe
   Mohamed, Ahmed
   Peden, Eric
   Rahimi, Maham
TI Contemporary Review to Reduce Groin Surgical Site Infections in Vascular
   Surgery
SO ANNALS OF VASCULAR SURGERY
LA English
DT Review
ID RESISTANT STAPHYLOCOCCUS-AUREUS; CONTAINING COLLAGEN IMPLANT; STERNAL
   WOUND INFECTIONS; FEMORAL-ARTERY ACCESS; CHLORHEXIDINE GLUCONATE; LOCAL
   APPLICATION; GRAFT INFECTIONS; MUSCLE FLAPS; RISK-FACTORS; ANTIMICROBIAL
   PROPHYLAXIS
AB Surgical site infection (SSIs) in lower extremity vascular procedures is a major contributor to patient morbidity and mortality. Despite previous advancements in preoperative and postoperative care, the surgical infection rate in vascular surgery remains high, particularly when groin incisions are involved. However, successfully targeting modifiable risk factors reduces the surgical site infection incidence in vascular surgery patients. We conducted an extensive literature review to evaluate the efficacy of various preventive strategies for groin surgical site infections. We discuss the role of preoperative showers, preoperative and postoperative antibiotics, collagen gentamicin implants, iodine impregnated drapes, types of skin incisions, negative pressure wound therapy, and prophylactic muscle flap transposition in preventing surgical site infection in the groin after vascular surgical procedures.
C1 [Rasheed, Haroon; Diab, Kaled; Singh, Tarundeep; Chauhan, Yusuf; Haddad, Paul; Zubair, M. Mujeeb; Vowels, Travis; Androas, Edward; Rojo, Manuel; Auyang, Phillip; McFall, Ross; Gomez, Luis Felipe; Mohamed, Ahmed; Peden, Eric; Rahimi, Maham] Houston Methodist Hosp, Methodist DeBakey Heart & Vasc Ctr, Houston, TX 77030 USA.
C3 Houston Methodist
RP Rahimi, M (通讯作者)，Houston Methodist Hosp, Dept Cardiovasc Surg, Smith Tower,6550 Fannin St,STE 1401, Houston, TX 77030 USA.
EM mrahimi@houstonmethodist.org
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NR 117
TC 16
Z9 19
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD APR
PY 2021
VL 72
BP 578
EP 588
DI 10.1016/j.avsg.2020.09.046
EA APR 2021
PG 11
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA RU0DW
UT WOS:000644823500005
PM 33157243
DA 2026-07-24
ER
PT J
AU Janssen, AHJ
   Wegdam, JA
   Reilingh, TSD
   Vermeulen, H
   Eskes, AM
AF Janssen, Alexandra H. J.
   Wegdam, Johannes A.
   Reilingh, Tammo S. de Vries
   Vermeulen, Hester
   Eskes, Anne M.
TI Which determinants are considered to be important for adherence to
   Negative Pressure Wound Therapy: A multimethods study
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Adherence; Shared decision making; Multimethod research; Negative
   pressure wound therapy; Quality of life
ID VACUUM-ASSISTED CLOSURE; LIFE-STYLE INTERVENTION; PATIENT; MANAGEMENT;
   OBESITY; HEALTH; CARE; NONRESPONSE; PREDICTORS; GUIDELINES
AB Aim: To explore the extent of patients that choose to cease Negative Pressure Wound Therapy (NPWT) prematurely in a clinical setting, and to explore the determinants of nonadherence.
   Method: This study exists out of: (1) a retrospective study to assess the number of patients who ceased NPWT prematurely; (2) a narrative review (NR) to identify determinants of nonadherence; and (3) a survey among wound care specialists to explore specific determinants of nonadherence to NPWT.
   Results: (1) Based on the retrospective study, 20% ceased NPWT prematurely because of experienced limitations in daily activities.
   (2) Based on 22 studies, 23 determinants that might influence nonadherence were identified and added as questions in the survey.
   (3) Twenty-two percent (n = 136) wound care specialists completed the survey. Confidence with the healthcare team, consistency in therapy advices, coping with pain, former negative experiences with NPWT, a normal activity pattern, social support from family or friends, and support from the healthcare team were identified as highly relevant determinants of nonadherence to NPWT. Only religion scored distinctively lower.
   Conclusion: This study is a first step in exploring the determinants of nonadherence to NPWT. In 20% NPWT was prematurely ceased at the request of the patient, this means that this therapy may have not been the best choice of therapy for this particular patient. The identification of potential determinants of nonadherence may help healthcare professionals in their dialogue with patients. The next step should be a prognostic study to assess which determinants best predict adherence to NPWT.
C1 [Janssen, Alexandra H. J.; Wegdam, Johannes A.; Reilingh, Tammo S. de Vries] Elkerliek Hosp, Dept Surg, Wesselmanlaan 25, NL-5707 HA Helmond, Netherlands.
   [Vermeulen, Hester] Radboud Univ Nijmegen, Sci Inst Qual Healthcare IQ Healthcare, Nijmegen, Netherlands.
   [Eskes, Anne M.] Univ Amsterdam, Dept Surg, Amsterdam UMC, Amsterdam, Netherlands.
   [Eskes, Anne M.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia.
   [Eskes, Anne M.] Griffith Univ, Sch Nursing & Midwifery, Gold Coast, Australia.
   [Janssen, Alexandra H. J.] Laag Strijp 9, NL-5735 PD Aarle Rixtel, Netherlands.
C3 Radboud University Nijmegen; University of Amsterdam; Griffith
   University; Menzies Health Institute Queensland; Griffith University
RP Janssen, AHJ (通讯作者)，Elkerliek Hosp, Dept Surg, Wesselmanlaan 25, NL-5707 HA Helmond, Netherlands.
EM sjanssen@elkerliek.nl
RI ; Eskes, Anne/HKV-3276-2023; Vermeulen, Hester/P-5739-2016
OI Eskes, Anne Maria/0000-0003-1605-0195; Janssen,
   Alexana/0000-0003-1816-0814; wegdam, johannes/0000-0002-3287-0233
CR [Anonymous], BR J NURS
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NR 50
TC 5
Z9 5
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD MAY
PY 2021
VL 30
IS 2
BP 250
EP 255
DI 10.1016/j.jtv.2021.01.009
EA APR 2021
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA RU2PP
UT WOS:000644992700015
PM 33581961
DA 2026-07-24
ER
PT J
AU Zhang, BR
   Fan, X
   Zhao, JC
   Shi, K
   Yu, JA
AF Zhang, Bo-Ru
   Fan, Xing
   Zhao, Jing-Chun
   Shi, Kai
   Yu, Jia-Ao
TI Negative pressure wound therapy with instillation and dwell time in the
   wound management of necrotizing fasciitis
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Necrotizing fasciitis; Negative pressure wound therapy; Wound bed
   preparation; Dwell time; Instillation therapy
ID RECOMMENDATIONS; DEBRIDEMENT; BIOBURDEN
AB Objective: Recent literature has shown that negative pressure wound therapy with instillation and dwell time (NPWTi-d) is a valid method of managing complex wounds and gained increasingly wider interest due in part to the increasing complexity of wounds. The purpose of this case study was to obtain information on the profile of NPWTi-d in necrotizing fasciitis patients, investigate the role it play in wound bed preparation, length of hospital stay and number of debridement operations.
   Methods: NPWTi-d has been used in patients with necrotizing fasciitis with either normal saline or Prontosan? solution and complete the treatment were involved in the present study. Following aggressive surgical debridement, NPWTi-d was initiated by instilling solution with a set dwell time of 5?10 min, followed by continuous NPWT of -125 mm Hg for 3?5 h. The system was changed on a 3?5 days schedule until sufficient granulation tissue was evident. Patients received systemic antibiotics and underwent wound debridement as indicated. Data of wound bed preparation, length of hospital stay, duration of NPWTi-d therapy, number of surgical interventions were collected retrospectively from patient medical records.
   Results: A total of 32 patients with diagnosis of necrotizing fasciitis received NPWTi-d were included. Granulation tissue was found to be sufficient in 9?16 days. The mean duration of NPWTi-d therapy was 12.5 days prior to wound closure by split-thickness autograft (n = 21), suture (n = 9), or flap transplantation (n = 2).Patients received NPWTi-d treatment over a period of 8?16 days. The mean length of hospitalization was 22.8 days. All wounds were successfully closed and no recurrence of infection or adverse event was observed during NPWTid treatment.
   Conclusion: In these patients, NPWTi-d facilitates wound cleansing and wound bed preparation and offers the clinician an additional tool for the management of necrotizing fasciitis. Further well designed prospective investigations with low risk of bias are needed to confirm these findings in the future work.
C1 [Zhang, Bo-Ru] First Hosp Jilin Univ, Cardiothorac Surg Care Platform, Changchun 130021, Peoples R China.
   [Fan, Xing; Zhao, Jing-Chun; Shi, Kai; Yu, Jia-Ao] First Hosp Jilin Univ, Dept Burn Surg, 71 Xinmin St, Changchun 130021, Peoples R China.
C3 Jilin University; Jilin University
RP Zhao, JC (通讯作者)，First Hosp Jilin Univ, Dept Burn Surg, 71 Xinmin St, Changchun 130021, Peoples R China.
EM jczhao@jlu.edu.cn
RI Zhang, Boru/AAN-8005-2020
FU Scientific and Technological Development Program of Jilin Province
   [20200201615JC]; Science and Technology Research Project of the
   Education Department of Jilin Province [JJKH20201074KJ]
FX This work received grants from the Scientific and Technological
   Development Program of Jilin Province (Grant No. 20200201615JC) ;
   Science and Technology Research Project of the Education Department of
   Jilin Province (Grant No. JJKH20201074KJ) .
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NR 35
TC 8
Z9 10
U1 0
U2 5
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD MAY
PY 2021
VL 30
IS 2
BP 262
EP 266
DI 10.1016/j.jtv.2021.02.012
EA APR 2021
PG 5
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA RU2PP
UT WOS:000644992700017
PM 33707160
DA 2026-07-24
ER
PT J
AU Park, S
   Son, BS
   Park, H
   Kim, HJ
   Park, SJ
   Kim, HY
AF Park, Seyeon
   Son, Bong Soo
   Park, Hyeonsoo
   Kim, Hye-Jin
   Park, Soon Ji
   Kim, Hee Young
TI Endoscopic vacuum therapy for cervical leakage following esophagectomy
   under monitored anesthesia care: a case report
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE Anastomotic leak; anesthesia; case report; endoscopy; esophagectomy;
   vacuum assisted closure (VAC)
AB Although esophagectomy is a standard treatment for esophageal cancer, anastomotic leak after esophagectomy is a relatively common complication and its incidence is 10-25% for cervical anastomosis. Endoscopic vacuum therapy (EVT) is a feasible primary treatment of esophageal perforations and leaks. Currently, there are no anesthesia guidelines for EVT, however, it is usually performed under general anesthesia with endotracheal intubation, especially for cervical EVT. Here, we report a successful EVT under monitored anesthesia care (MAC) without any complication, which doesn't need to intubate the patient. A 64-year-old male with upper esophageal cancer underwent an Ivor-Lewis operation with cervical anastomosis. Vacuum assisted closure (VAC) was performed for cervical leak under general anesthesia, but there was no further improvement. Although EVT was attempted under sedation with midazolam in an endoscopy room, the procedure was discontinued because of desaturation. Furthermore, the thoracic surgeon was concerned about the possibility of dyspnea and hypoxia even after the procedure. EVT was scheduled under MAC at the request of a thoracic surgeon and medical doctor, as EVT was expected to lead to patient discomfort and difficult airway. EVT was performed successfully with no respiratory depression or patient movement using target controlled infusion with 2% propofol and remifentanil. The patient was discharged on the 78th POD without any other complications. EVT for cervical leak after esophagectomy can be successfully performed with MAC, and understanding the general condition of the patient, cooperation with the patient and the surgeon, and providing continuous oxygen supply to the patient are necessary for a successful procedure under MAC.
C1 [Park, Seyeon; Park, Hyeonsoo; Kim, Hye-Jin; Park, Soon Ji; Kim, Hee Young] Pusan Natl Univ, Dept Anesthesia & Pain Med, Yangsan Hosp, 20 Geumo Ro, Yangsan 50612, South Korea.
   [Son, Bong Soo] Pusan Natl Univ, Dept Thorac & Cardiovasc Surg, Yangsan Hosp, Yangsan, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital
RP Kim, HY (通讯作者)，Pusan Natl Univ, Dept Anesthesia & Pain Med, Yangsan Hosp, 20 Geumo Ro, Yangsan 50612, South Korea.
EM anekhy@gmail.com
RI Kim, Hee Young/HII-5042-2022
OI 박, 세연/0000-0001-7183-1811
FU Pusan National University Yangsan Hospital
FX This work was supported by a 2020 research grant from Pusan National
   University Yangsan Hospital.
CR Alanezi Khaled, 2004, Ann Thorac Cardiovasc Surg, V10, P71
   Glass GE, 2014, BJS-BRIT J SURG, V101, P1627, DOI 10.1002/bjs.9636
   Hwang JJ, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003416
   Kuehn F, 2017, SURG ENDOSC, V31, P3449, DOI 10.1007/s00464-016-5404-x
   Lerut T, 2002, DIGEST SURG, V19, P92, DOI 10.1159/000052018
   Miller RD, 2011, CHOICE ANESTHETIC TE, V6TH, P194
   Still S, 2018, ANN THORAC CARDIOVAS, V24, P173, DOI 10.5761/atcs.oa.17-00107
   Turkyilmaz A, 2009, DIS ESOPHAGUS, V22, P119, DOI 10.1111/j.1442-2050.2008.00866.x
NR 8
TC 0
Z9 0
U1 0
U2 1
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD APR
PY 2021
VL 10
IS 4
BP 4906
EP 4910
DI 10.21037/apm-20-1394
PG 5
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA RW5PK
UT WOS:000646574100124
PM 33183021
OA gold
DA 2026-07-24
ER
PT J
AU Andrianello, S
   Landoni, L
   Bortolato, C
   Iudici, L
   Tuveri, M
   Pea, A
   De Pastena, M
   Malleo, G
   Bonamini, D
   Manzini, G
   Bassi, C
   Salvia, R
AF Andrianello, Stefano
   Landoni, Luca
   Bortolato, Cecilia
   Iudici, Livio
   Tuveri, Massimiliano
   Pea, Antonio
   De Pastena, Matteo
   Malleo, Giuseppe
   Bonamini, Deborah
   Manzini, Gessica
   Bassi, Claudio
   Salvia, Roberto
TI Negative pressure wound therapy for prevention of surgical site
   infection in patients at high risk after clean-contaminated major
   pancreatic resections: A single-center, phase 3, randomized clinical
   trial
SO SURGERY
LA English
DT Article
ID INTERNATIONAL STUDY-GROUP; COMPLICATIONS; SURGERY;
   PANCREATICODUODENECTOMY; DEFINITION; LAPAROTOMY
AB Background: Surgical site infections are an important burden of pancreatic surgery, prolonging hospitalization and delaying adjuvant treatment. The aim of this study was to compare negative pressure wound therapy with standard sterile dressing in terms of the prevention of non-organ-space surgical site infection (superficial and deep surgical site infection) in the high risk setting.
   Methods: The trial was conducted at the University of Verona Hospital Trust, Verona, Italy, from July 25, 2018, through October 10, 2019, among adults undergoing surgery for periampullary neoplasms. Only patients at high-risk for surgical site infection based on body mass index, diabetes, steroids, neoadjuvant therapy, American Society of Anesthesiologists score, Charlson comorbidity index, duration of surgery, and blood loss were included and randomized.
   Results: A total of 351 patients were screened, 100 met the inclusion criteria and were 1:1 allocated in the 2 arms. The difference in terms of non-organ-space surgical site infection comparing negative pressure wound therapy with standard sterile dressing was not significant (10.9 vs 12.2%, risk ratio [RR] 1.144, confidence interval [CI] 95% 0.324-4.040, P = 1.000). Hematomas (4.3 vs 2%, RR 1.565, CI 95% 0.312-7.848, P =.609) and organ-space infections (46.7 vs 43.8%, RR 1.059, CI 95% 0.711-1.576, P =.836) were similar. Negative pressure wound therapy prevented the development of seromas (0 vs 12.2%, RR 0.483, CI 95% 0.390-0.599, P = .027). The aesthetic result assessed on postoperative day 7 was better in the negative pressure wound therapy group (visual analogue scale, 8 vs 7, P = .029; Stony Brook Scar Evaluation Scale, 3.2 vs 2.5, P = .009), but it was no more evident on postoperative day 30 after a total number of 23 dropouts.
   Conclusion: Compared with standard sterile dressing, negative pressure wound therapy is not associated with an improved rate of non-organ-space surgical site infection after surgery for periampullary neoplasms in patients at high risk for surgical site infection. Additional studies will help identify the population that could benefit most from this intervention.
   (c) 2020 Elsevier Inc. All rights reserved.
C1 [Andrianello, Stefano; Landoni, Luca; Bortolato, Cecilia; Iudici, Livio; Tuveri, Massimiliano; Pea, Antonio; De Pastena, Matteo; Malleo, Giuseppe; Bonamini, Deborah; Manzini, Gessica; Bassi, Claudio; Salvia, Roberto] Univ Verona Hosp Trust, Dept Gen & Pancreat Surg, Pancreas Inst, Ple Scuro 10, I-37134 Verona, Italy.
C3 University of Verona; Azienda Ospedaliera Universitaria Integrata Verona
RP Bassi, C (通讯作者)，Univ Verona Hosp Trust, Dept Gen & Pancreat Surg, Pancreas Inst, Ple Scuro 10, I-37134 Verona, Italy.
EM claudio.bassi@univr.it
RI Pea, Antonio/AAC-5994-2022; De Pastena, Matteo/J-5623-2019; Malleo,
   Giuseppe/J-1773-2018; Malleo, Giuseppe/J-4395-2012; Andrianello,
   Stefano/H-9655-2019
OI Pea, Antonio/0000-0002-0509-6756; Landoni, Luca/0000-0002-2474-3496; De
   Pastena, Matteo/0000-0001-5244-4357; Malleo,
   Giuseppe/0000-0001-5467-2628; BONAMINI, Deborah/0000-0001-7439-2754;
   Malleo, Giuseppe/0000-0001-5467-2628; 
FU Associazione Italiana per la Ricerca sul Cancro (AIRC) [12182, 17132];
   Italian Ministry of Health [FIMPCUP_J33G13000210001]; FP7 European
   Community Grant Cam-Pac [602783]
FX This work was supported by Associazione Italiana per la Ricerca sul
   Cancro (AIRC n.12182 and n.17132); the Italian Ministry of Health
   (FIMPCUP_J33G13000210001); and the FP7 European Community Grant Cam-Pac
   (n. 602783). The funding agencies had no role in the collection,
   analysis, and interpretation of data or in the writing of the
   manuscript. The authors did not provide preregistration for this study.
   If requested, de-identified data collected for this randomized clinical
   trial, the study protocol, and informed consent forms will be made
   available. Please contact the institutional review board (Comitato Etico
   delle Provice di Verona e Rovigo), which will review all requests
   received. All studies carried out with these data will be supported by
   the investigators of this trial only after approval by the institutional
   review board.
CR Bassi C, 2017, SURGERY, V161, P584, DOI 10.1016/j.surg.2016.11.014
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NR 36
TC 19
Z9 22
U1 0
U2 10
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
EI 1532-7361
J9 SURGERY
JI Surgery
PD MAY
PY 2021
VL 169
IS 5
BP 1069
EP 1075
DI 10.1016/j.surg.2020.10.029
EA MAY 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RY1PQ
UT WOS:000647689600021
PM 33257037
DA 2026-07-24
ER
PT J
AU Wei, ZY
   Wang, Q
   Wang, YF
   Fang, XJ
   Zhu, YX
   Cheng, JT
AF Wei, Zhiyi
   Wang, Qian
   Wang, Yanfeng
   Fang, Xiangjian
   Zhu, Yixin
   Cheng, Juntao
TI Necrotizing Fasciitis Shock Syndrome by Group A Hemolytic Streptococcus:
   Report of 6 Cases and Clinical Management
SO CLINICAL LABORATORY
LA English
DT Article
DE type II necrotizing fasciitis streptococcal toxic shock syndrome (STSS);
   group A hemolytic streptococcus (GAS); vacuum sealing drainage (VSD)
AB Background: To explore the comprehensive treatment of group A streptococcus haemolyticus complicated with streptococcal toxic shock syndrome (STSS) in surgery.
   Methods: Six patients with Type II necrotizing fasciitis complicated with STSS were enrolled from September 2018 to October 2019 in the Burn Department at Quanzhou First Hospital. The patients were treated with early incision and reduction of tension, anti-shock, anti-infection, primary debridement and vacuum suction, maintenance of organ function, and adjustment of internal environment, secondary autologous skin graft, and early rehabilitation.
   Results: Five patients were healed, while one elderly patient refused treatment.
   Conclusions: We should be alert to necrotizing fasciitis caused by group A hemolytic streptococcus (GAS) infection and effectively avoid the occurrence of STSS. By making an incision to reduce tension, adopting the principle of anti-infection, and actively anti-shock, maintaining the function of internal organs and the stability of internal environment, debridement and vacuum suction in early and effective stage, followed by self-skin graft to seal the wound and early rehabilitation the treatment of Type II NF and STSS can be effectively improved.
C1 [Wei, Zhiyi; Fang, Xiangjian; Zhu, Yixin; Cheng, Juntao] Quanzhou First Hosp, Dept Burn Intens Care Unit, 250 Dongjie Rd, Quanzhou 362000, Fujian, Peoples R China.
   [Wang, Qian] Quanzhou Coll Vocat Sch & Stomatol, Quanzhou, Fujian, Peoples R China.
   [Wang, Yanfeng] Xiamen Univ, Affiliated Hosp 1, Sch Med, Dept Clin Lab, Xiamen, Fujian, Peoples R China.
C3 Xiamen University
RP Cheng, JT (通讯作者)，Quanzhou First Hosp, Dept Burn Intens Care Unit, 250 Dongjie Rd, Quanzhou 362000, Fujian, Peoples R China.
EM c5481@sina.com
RI Wang, YanFeng/IAO-6494-2023
CR Bi Fan, 2018, Zhongguo Yi Liao Qi Xie Za Zhi, V42, P46, DOI 10.3969/j.issn.1671-7104.2018.01.012
   Bonne SL, 2017, INFECT DIS CLIN N AM, V31, P497, DOI 10.1016/j.idc.2017.05.011
   Chuang KL, 2018, ANN PLAS SURG, V80, pS75, DOI 10.1097/SAP.0000000000001298
   Ikebe T, 2015, EPIDEMIOL INFECT, V143, P864, DOI 10.1017/S0950268814001265
   Kawecki Marek, 2015, Pol Przegl Chir, V87, P1, DOI [10.1515/pjs-2015-0010, 10.1515/pjs-2015-0010]
   Li Longzhu, 2015, Zhonghua Shao Shang Za Zhi, V31, P98
   Liu Mengyao, 2018, Jpn J Med (Lond), V1, P269, DOI [10.31488/jjm.1000127, 10.31488/jjm.1000127]
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   Vilallonga R, 2019, J SURG CASE REP, DOI 10.1093/jscr/rjz269
NR 13
TC 2
Z9 2
U1 0
U2 6
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2021
VL 67
IS 3
BP 851
EP 856
DI 10.7754/Clin.Lab.2020.200801
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA RZ6XJ
UT WOS:000648745300026
PM 33739051
DA 2026-07-24
ER
PT J
AU González-Hadad, A
   Ordoñez, CA
   Parra, MW
   Caicedo, Y
   Padilla, N
   Millán, M
   García, A
   Vidal-Carpio, JM
   Pino, LF
   Herrera, MA
   Quintero, L
   Hernández, F
   Flórez, G
   Rodríguez-Holguín, F
   Salcedo, A
   Serna, JJ
   Franco, MJ
   Ferrada, R
   Navsaria, PH
AF Gonzalez-Hadad, Adolfo
   Ordonez, Carlos A.
   Parra, Michael W.
   Caicedo, Yaset
   Padilla, Natalia
   Millan, Mauricio
   Garcia, Alberto
   Vidal-Carpio, Jenny Marcela
   Pino, Luis Fernando
   Herrera, Mario Alain
   Quintero, Laureano
   Hernandez, Fabian
   Florez, Guillermo
   Rodriguez-Holguin, Fernando
   Salcedo, Alexander
   Serna, Jose Julian
   Franco, Maria Josefa
   Ferrada, Ricardo
   Navsaria, Pradeep H.
TI Damage control in penetrating cardiac trauma
SO COLOMBIA MEDICA
LA English
DT Review
DE Thoracic Ultrasound; Damage Control Surgery; Penetrating cardiac trauma;
   cardiac tamponade; thoracotomy; advanced trauma life support care;
   negative-pressure wound therapy; sternotomy; pericardiectomy; death,
   sudden; hemothora; chest tubes; pneumothorax; pericardial window
   techniques
ID ULTRASOUND; MANAGEMENT; INJURIES
AB Definitive management of hemodynamically stable patients with penetrating cardiac injuries remains controversial between those who propose aggressive invasive care versus those who opt for a less invasive or non-operative approach. This controversy even extends to cases of hemodynamically unstable patients in which damage control surgery is thought to be useful and effective. The aim of this article is to delineate our experience in the surgical management of penetrating cardiac injuries via the creation of a clear and practical algorithm that includes basic principles of damage control surgery. We recommend that all patients with precordial penetrating injuries undergo trans-thoracic ultrasound screening as an integral component of their initial evaluation. In those patients who arrive hemodynamically stable but have a positive ultrasound, a pericardial window with lavage and drainage should follow. We want to emphasize the importance of the pericardial lavage and drainage in the surgical management algorithm of these patients. Before this concept, all positive pericardial windows ended up in an open chest exploration. With the coming of the pericardial lavage and drainage procedure, the reported literature and our experience have shown that 25% of positive pericardial windows do not benefit and/or require further invasive procedures. However, in hemodynamically unstable patients, damage control surgery may still be required to control ongoing bleeding. For this purpose, we propose a surgical management algorithm that includes all of these essential clinical aspects in the care of these patients.
C1 [Gonzalez-Hadad, Adolfo; Ordonez, Carlos A.; Garcia, Alberto; Pino, Luis Fernando; Herrera, Mario Alain; Quintero, Laureano; Hernandez, Fabian; Florez, Guillermo; Salcedo, Alexander; Serna, Jose Julian] Univ Valle, Fac Salud, Escuela Med, Dept Surg,Div Trauma & Acute Care Surg, Cali, Colombia.
   [Gonzalez-Hadad, Adolfo; Pino, Luis Fernando; Herrera, Mario Alain; Hernandez, Fabian; Salcedo, Alexander; Serna, Jose Julian; Ferrada, Ricardo] Hosp Univ Valle, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Gonzalez-Hadad, Adolfo; Quintero, Laureano; Ferrada, Ricardo] Ctr Med Imbanaco, Cali, Colombia.
   [Ordonez, Carlos A.; Garcia, Alberto; Rodriguez-Holguin, Fernando; Salcedo, Alexander; Serna, Jose Julian; Franco, Maria Josefa] Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Ordonez, Carlos A.; Millan, Mauricio; Garcia, Alberto; Salcedo, Alexander; Serna, Jose Julian] Univ Icesi, Cali, Colombia.
   [Parra, Michael W.] Broward Gen Level I Trauma Ctr, Dept Trauma Crit Care, Ft Lauderdale, FL USA.
   [Caicedo, Yaset; Padilla, Natalia] Fdn Valle Lili, Ctr Invest Clin CIC, Cali, Colombia.
   [Millan, Mauricio] Fdn Valle Lili, Div Transplant Surg, Dept Surg, Cali, Colombia.
   [Vidal-Carpio, Jenny Marcela] Hosp Gen Teofilo Davila, Serv Emergencias, Cuenca, Ecuador.
   [Vidal-Carpio, Jenny Marcela] Univ Cuenca, Dept Surg, Cuenca, Ecuador.
   [Navsaria, Pradeep H.] Univ Cape Town, Groote Schuur Hosp, Fac Hlth Sci, Trauma Ctr, Anzio Rd, Cape Town, South Africa.
C3 Universidad del Valle; Universidad del Valle; Fundacion Valle del Lili;
   Universidad ICESI; Fundacion Valle del Lili; Fundacion Valle del Lili;
   Universidad de Cuenca; University of Cape Town
RP Ordoñez, CA (通讯作者)，Univ Valle, Fac Salud, Escuela Med, Dept Surg,Div Trauma & Acute Care Surg, Cali, Colombia.; Ordoñez, CA (通讯作者)，Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
EM ordonezcarlosa@gmail.com
RI Herrera, Mario Alain/LRB-9290-2024; Navsaria, Pradeep/AAS-1807-2020
OI Herrera, Mario Alain/0000-0002-4526-7636; Navsaria,
   Pradeep/0000-0002-5152-3317; Padilla-Londoño,
   Natalia/0000-0003-3292-6919; PINO OLIVEROS, LUIS
   FERNANDO/0000-0002-1179-2854
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   Nicol AJ, 2018, TREATMENT ONGOING HE, P67
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NR 25
TC 8
Z9 13
U1 0
U2 4
PU CORPORACION EDITORA MEDICA VALLE
PI CALI
PA UNIV VALLE, BLDG 118 FACULTY HEALTH, CALLE 4B 36-00, CALI, 00000,
   COLOMBIA
SN 1657-9534
J9 COLOMB MEDICA
JI Colomb. Medica
PY 2021
VL 52
IS 2
AR e4034519
DI 10.25100/cm.v52i2.4519
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RZ9EA
UT WOS:000648900100003
PM 34188321
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Saunders, C
   Nherera, LM
   Horner, A
   Trueman, P
AF Saunders, C.
   Nherera, L. M.
   Horner, A.
   Trueman, P.
TI Single-use negative-pressure wound therapy versus conventional dressings
   for closed surgical incisions: systematic literature review and
   meta-analysis
SO BJS OPEN
LA English
DT Review
ID INFECTION; TRIAL
AB Background: Surgical-site complications (SSCs) remain a significant cause of morbidity and mortality, particularly in high-risk patients. The aim of this study was to determine whether prophylactic use of a specific single-use negative-pressure wound therapy (sNPWT) device reduced the incidence of SSCs after closed surgical incisions compared with conventional dressings.
   Methods: A systematic literature review was performed using MEDLINE, Embase and the Cochrane Library to identify articles published from January 2011 to August 2018. RCTs and observational studies comparing PICO (TM) sNPWT with conventional dressings, with at least 10 patients in each treatment arm, were included. Meta-analyses were performed to determine odds ratios (ORs) or mean differences (MDs), as appropriate. PRISMA guidelines were followed. The primary outcome was surgical-site infection (SSI). Secondary outcomes were other SSCs and hospital efficiencies. Risk of bias was assessed.
   Results: Of 6197 citations screened, 29 studies enrolling 5614 patients were included in the review; all studies included patients with risk factors for SSCs. sNPWT reduced the number of SSIs (OR 0.37, 95 per cent c.i. 0.28 to 0.50; number needed to treat (NNT) 20). sNPWT reduced the odds of wound dehiscence (OR 0.70, 0.53 to 0.92; NNT 26), seroma (OR 0.23, 0.11 to 0.45; NNT 13) and necrosis (OR 0.11, 0.03 to 0.39; NNT 12). Mean length of hospital stay was shorter in patients who underwent sNPWT (MD -1.75, 95 per cent c.i. -2.69 to -0.81).
   Conclusion: Use of the sNPWT device in patients with risk factors reduced the incidence of SSCs and the mean length of hospital stay.
C1 [Saunders, C.; Horner, A.] Smith Nephew, Global Clin Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
   [Nherera, L. M.; Trueman, P.] Smith Nephew, Hlth Econ & Market Access, Kingston Upon Hull, N Humberside, England.
C3 Smith & Nephew; Smith & Nephew
RP Saunders, C (通讯作者)，Smith Nephew, Global Clin Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM Christopher.Saunders@smith-nephew.com
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
   Ambler G, 2018, FLUID HANDLING NEGAT
   [Anonymous], SYSTEMATIC REV CRDS
   Chaboyer W, 2014, HEALTHCARE, V2, P417, DOI 10.3390/healthcare2040417
   Critical Appraisal Skills Programme, CASP CHECKL 12 QUEST
   Dingemans SA, 2018, INT ORTHOP, V42, P747, DOI 10.1007/s00264-018-3781-6
   Fleming CA, 2018, J HOSP INFECT, V99, P75, DOI 10.1016/j.jhin.2017.10.022
   Galiano RD, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001560
   Gillespie BM, 2015, SURG INNOV, V22, P488, DOI 10.1177/1553350615573583
   Gillespie BM, 2013, WOUND PRACT RES, V21, P74
   Gupta R, 2017, AM SURGEON, V83, P1166
   Hackney L, 2017, 12 SCIENT ANN M EUR
   Hester T, 2015, Advances in Orthopedic Surgery, V2015, P1, DOI [10.1155/2015/247324, 10.1155/2015/247324, DOI 10.1155/2015/247324]
   Hickson E, 2015, SURG INFECT, V16, P174, DOI 10.1089/sur.2014.145
   Holt R, 2015, BRIT J HOSP MED, V76, P217, DOI 10.12968/hmed.2015.76.4.217
   Hyldig N, 2019, BJOG-INT J OBSTET GY, V126, P628, DOI 10.1111/1471-0528.15413
   Irwin G, 2018, ASS BREAST SURG C BI
   Karlakki SL, 2016, BONE JOINT RES, V5, P328, DOI 10.1302/2046-3758.58.BJR-2016-0022.R1
   Kawakita T, 2018, AM J OBSTET GYNECOL, V218, pS323
   Korol E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083743
   Matsumoto T, 2015, FOOT ANKLE INT, V36, P787, DOI 10.1177/1071100715574934
   Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
   Nordmeyer M, 2016, INT WOUND J, V13, P1176, DOI 10.1111/iwj.12436
   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
   Pellino G, 2014, INT J SURG, V12, pS64, DOI 10.1016/j.ijsu.2014.08.378
   Pellino G, 2014, SURG INNOV, V21, P204, DOI 10.1177/1553350613496906
   Selvaggi Francesco, 2014, Surg Technol Int, V24, P83
   Svensson-Björk R, 2018, WOUND REPAIR REGEN, V26, P77, DOI 10.1111/wrr.12615
   Tan KW, 2017, ANN VASC DIS, V10, P386, DOI 10.3400/avd.oa.17-00052
   Tanaydin V, 2018, AESTHET PLAST SURG, V42, P927, DOI 10.1007/s00266-018-1095-0
   Tuuli MG, 2017, AM J OBSTET GYNECOL, V216, pS245, DOI 10.1016/j.ajog.2016.11.670
   Uchino M, 2016, DIGEST SURG, V33, P449, DOI 10.1159/000446550
   van der Valk MJM, 2017, ADV WOUND CARE, V6, P425, DOI 10.1089/wound.2017.0749
   Witt-Majchrzak Anna, 2015, Pol Przegl Chir, V86, P456, DOI [10.2478/pjs-2014-0082, 10.2478/pjs-2014-0082]
   World Union of Healing Societies, CLOS SURG INC MAN UN
   Zotes V, 2015, INTERACT CARDIOV TH, V21, P187
NR 36
TC 24
Z9 26
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD JAN
PY 2021
VL 5
IS 1
AR zraa003
DI 10.1093/bjsopen/zraa003
EA JAN 2021
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SA6VX
UT WOS:000649440900001
PM 33609382
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Murphy, JA
   Myers, D
   Trueman, P
   Searle, R
AF Murphy, J. A.
   Myers, D.
   Trueman, P.
   Searle, R.
TI Cost-effectiveness of single-use negative-pressure therapy compared with
   standard care for prevention of reconstruction failure in prepectoral
   breast reconstruction
SO BJS OPEN
LA English
DT Article
ID IMMEDIATE; METAANALYSIS
AB Background: Single-use negative-pressure wound therapy (sNPWT) has been reported to reduce the incidence of reconstruction failure in prepectoral breast reconstruction compared with standard surgical dressings. The aim of this economic evaluation was to investigate the cost-effectiveness of sNPWT compared with standard care for the prevention of reconstruction failure in prepectoral breast reconstruction in the UK.
   Method: A decision tree model was used to estimate the expected cost and effectiveness per patient. Effectiveness was measured both by the number of reconstruction failures avoided and the gain in quality-adjusted life-years (QALYs). The baseline incidence of reconstruction failure (8.6 per cent) was taken from a recently published study of 2655 mastectomies in the UK. The effectiveness of sNPWT used results from a clinical study comparing sNPWT with standard dressings. Previously published utility weights were applied. The cost of reconstruction failure was estimated from detailed resource data from patients with reconstruction failure, applying National Health Service reference costs. One-way, probabilistic, scenario and threshold analyses were conducted.
   Results: The undiscounted cost per patient associated with reconstruction failure was estimated to be 23 pound 628 (22 pound 431 discounted). The use of sNPWT was associated with an expected cost saving of 1706 pound per patient, an expected increase in QALYs of 0.0187 and an expected 0.0834 reconstruction failures avoided. Cost-effectiveness acceptability analysis demonstrated that, at a threshold of 20 pound 000 per QALY, 99.94 per cent of the simulations showed sNPWT to be more cost-effective than standard care.
   Conclusion: Among patients undergoing immediate prepectoral breast reconstruction, the use of sNPWT is more cost-effective than standard dressings.
C1 [Murphy, J. A.] Manchester Univ NHS Fdn Trusts, Nightingale Breast Unit, Manchester, Lancs, England.
   [Trueman, P.; Searle, R.] Smith & Nephew, Kingston Upon Hull, N Humberside, England.
C3 Smith & Nephew
RP Murphy, JA (通讯作者)，Wythenshawe Hosp, Nightingale Breast Unit, Southmoor Rd, Manchester M23 9LT, Lancs, England.
EM john.murphy@mft.nhs.uk
CR [Anonymous], Breast cancer incidence
   Association of Breast Surgery British Association of Plastic Reconstructive and Aesthetic Surgeons, 2012, ONCOPLASTIC BREAST R
   Baker BG, 2018, PLAST RECONSTR SURG, V141, P1077, DOI 10.1097/PRS.0000000000004270
   Briggs Andrew., 2006, DECISION MODELLING H
   Galiano RD, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001560
   Highton L, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001488
   Hyldig N, 2019, BJOG-INT J OBSTET GY, V126, P619, DOI 10.1111/1471-0528.15573
   Irwin GW, 2020, PRS-GLOB OPEN, V8, DOI 10.1097/GOX.0000000000002667
   Jeevan R, 2020, ANN ROY COLL SURG, V102, P110, DOI 10.1308/rcsann.2019.0101
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   National Institute for Health and Care Excellence (NICE), 2019, MEDICAL TECHNOLOGIES
   NHS, 201819 NATL COST COL
   O'Connell RL, 2019, BRIT J CANCER, V120, P883, DOI 10.1038/s41416-019-0438-1
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   Razdan SN, 2016, PLAST RECONSTR SURG, V137, p510E, DOI 10.1097/01.prs.0000479935.92904.a3
   Singh JK, 2020, BJS-BRIT J SURG, V107, P227, DOI 10.1002/bjs.11383
   Siotos C, 2019, PLAST RECONSTR SURG, V143, p276E, DOI 10.1097/PRS.0000000000005194
   Strugala V, 2017, SURG INFECT, V18, P810, DOI 10.1089/sur.2017.156
   Teo I, 2015, PLAST AESTHET RES, V2, P320, DOI 10.4103/2347-9264.169494
   Yoon AY, 2019, ANN SURG ONCOL, V26, P1190, DOI 10.1245/s10434-019-07160-x
NR 26
TC 4
Z9 6
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD MAR
PY 2021
VL 5
IS 2
AR zraa042
DI 10.1093/bjsopen/zraa042
EA APR 2021
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SA6WK
UT WOS:000649442200025
PM 33839751
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Martynov, I
   Gosemann, JH
   Hofmann, AD
   Kuebler, JF
   Madadi-Sanjani, O
   Ure, BM
   Lacher, M
AF Martynov, Illya
   Gosemann, Jan-Hendrik
   Hofmann, Alejandro D.
   Kuebler, Joachim F.
   Madadi-Sanjani, Omid
   Ure, Benno M.
   Lacher, Martin
TI Vacuum-assisted closure (VAC) prevents wound dehiscence following
   posterior sagittal anorectoplasty (PSARP): An exploratory case-control
   study
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Anorectal malformations; Posterior sagittal anorectoplasty; Wound
   dehiscence; Vacuum-assisted closure
ID ANORECTAL-MALFORMATIONS; MANAGEMENT; COLOSTOMY; REPAIR; ARM
AB Background: Wound dehiscence (WD) of the anocutaneous anastomosis or perineal body after posterior sagittal anorectoplasty (PSARP) is common. We aimed to evaluate the efficacy of a perineal vacuum-assisted closure (VAC) for prevention of WD following repair of anorectal malformations (ARM) with rectoperineal and rectovestibular fistula.
   Methods: A retrospective dual-center case-control study of children undergoing PSARP without colostomy between 2011 and 2019 was performed. The VAC group received preoperative bowel preparation (PBP), postoperative appli-cation of a VAC, loperamide (only Location A), intravenous antibiotics (IA), and total parenteral nutrition (TPN). The non-VAC group underwent PBP, loperamide (Location A), IA, and TPN without VAC. Primary outcome was WD at the anocutaneous anastomosis or reconstructed perineal body within the first 14 days after surgery.
   Results: The study population included 18 patients (VAC group) and 20 children (non-VAG group) with rectoperineal and rectovestibular fistula. The incidence of WD in the VAC group was 0% compared to 25% in the non-VAC group (0/18 vs. 5/20, p = 0.04). No VAC related complications occurred.
   Conclusion: Postoperative application of a VAC embedded in a perioperative treatment protocol has the potential to prevent wound dehiscence of the neoanus and reconstructed perineal body following PSARP.
   Type of study: Case-control study. Level of evidence: Level III.
   (c) 2020 Elsevier Inc. All rights reserved.
C1 [Martynov, Illya; Gosemann, Jan-Hendrik; Lacher, Martin] Univ Leipzig, Dept Pediat Surg, Liebigstr 20 a, D-04103 Leipzig, Germany.
   [Hofmann, Alejandro D.; Kuebler, Joachim F.; Madadi-Sanjani, Omid; Ure, Benno M.] Hannover Med Sch, Dept Pediat Surg, Hannover, Germany.
C3 Leipzig University; Hannover Medical School
RP Martynov, I (通讯作者)，Univ Leipzig, Dept Pediat Surg, Liebigstr 20 a, D-04103 Leipzig, Germany.
EM Illya.Martynov@medizin.uni-leipzig.de
RI /AAS-1006-2020
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
   Allam AM, 2017, ANN PEDIATR SURG, V13, P140, DOI 10.1097/01.XPS.0000508435.98985.a2
   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
   Chandramouli B, 2004, J PEDIATR SURG, V39, P596, DOI 10.1016/j.jpedsurg.2003.12.016
   de Jesus LE, 2018, J PEDIATR SURG, V53, P585, DOI 10.1016/j.jpedsurg.2017.11.048
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   Lauriti G, 2019, PEDIATR SURG INT, V35, P77, DOI 10.1007/s00383-018-4378-2
   Leva Ernesto, 2013, J Neonatal Surg, V2, P3
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   Tofft L, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/2930783
   Ullman AJ, 2015, PEDIATRICS, V136, pE1331, DOI 10.1542/peds.2015-1507
   van Der Steeg HJJ, 2019, J PEDIATR SURG, V54, P1595, DOI 10.1016/j.jpedsurg.2019.03.008
   van der Steeg HJJ, 2015, TECH COLOPROCTOL, V19, P181, DOI 10.1007/s10151-015-1267-8
   Vilanova-Sanchez A, 2018, J PEDIATR SURG, V53, P698, DOI 10.1016/j.jpedsurg.2017.07.012
   Wood RJ, 2018, CLIN COLON RECT SURG, V31, P61, DOI 10.1055/s-0037-1609020
NR 32
TC 8
Z9 9
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD APR
PY 2021
VL 56
IS 4
BP 745
EP 749
DI 10.1016/j.jpedsurg.2020.07.009
EA MAY 2021
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA SA9PQ
UT WOS:000649635500020
PM 32778448
DA 2026-07-24
ER
PT J
AU Yasuda, JL
   Svetanoff, WJ
   Staffa, SJ
   Zendejas, B
   Hamilton, TE
   Jennings, RW
   Ngo, PD
   Smithers, CJ
   Manfredi, MA
AF Yasuda, Jessica L.
   Svetanoff, Wendy Jo
   Staffa, Steven J.
   Zendejas, Benjamin
   Hamilton, Thomas E.
   Jennings, Russell W.
   Ngo, Peter D.
   Smithers, C. Jason
   Manfredi, Michael A.
TI Prophylactic negative vacuum therapy of high-risk esophageal anastomoses
   in pediatric patients
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE Esophageal atresia; Vacuum assisted closure; Evac; Esophageal leak
ID ATRESIA; REPAIR; STRICTURE; LONG; COMPLICATIONS; CHILDREN
AB Background: Esophageal anastomoses are at risk for leak or stricture. Negative pressure vacuum-assisted closure (VAC) therapy is used to treat leak. We hypothesized that a prophylactic VAC (pEVAC) at the time of new anastomosis may lead to fewer leaks and strictures.
   Methods: Single center retrospective case-control study of patients undergoing high-risk esophageal anastomoses between July 2015 and January 2019. Outcomes of leak and long-term anastomotic failure (refractory stricture requiring surgery) were compared between groups.
   Results: Sixteen patients had a pEVAC placed during LGEA repair ( N = 10) or stricture resection ( N = 6). Of pEVAC cases, 3 ( N = 1 Foker, N = 2 stricture resections) experienced leak (18.8%). In comparison, leak occurred in 9/41 (22%) Foker patients and in 1/20 (5%) stricture resections without pEVAC, all p > 0.05. Long-term anastomotic failure was more common in the pEVAC cohort versus controls (56.3% versus 11.5%, p < 0.001).
   Conclusions: Prophylactic EVAC placement does not appear to reduce leak and is associated with significantly greater odds of long-term anastomotic failure. Further device refinement could improve its potential role in prophylaxis of high-risk anastomoses, but future research is needed to better understand optimal patient selection, device design, and duration of pEVAC therapy. (C)& nbsp;2020 Elsevier Inc. All rights reserved.
C1 [Yasuda, Jessica L.; Ngo, Peter D.; Manfredi, Michael A.] Boston Childrens Hosp, Div Gastroenterol Hepatol & Nutr, 300 Longwood Ave, Boston, MA 02115 USA.
   [Svetanoff, Wendy Jo; Zendejas, Benjamin; Hamilton, Thomas E.; Jennings, Russell W.; Smithers, C. Jason] Boston Childrens Hosp, Dept Gen Surg, Boston, MA USA.
   [Staffa, Steven J.] Boston Chilrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Boston, MA USA.
   [Svetanoff, Wendy Jo] Childrens Mercy Kansas City, Dept Pediat Surg, Kansas City, MO USA.
   [Smithers, C. Jason] Johns Hopkins All Childrens Hosp, Dept Surg, St Petersburg, FL USA.
C3 Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Children's Mercy Hospital; Johns
   Hopkins University; Johns Hopkins Medicine
RP Yasuda, JL (通讯作者)，Boston Childrens Hosp, Div Gastroenterol Hepatol & Nutr, 300 Longwood Ave, Boston, MA 02115 USA.
RI ; Hamilton, Thomas/GQB-4837-2022
OI Jennings, Russell/0000-0002-0133-2707; 
CR [Anonymous], J PEDIATR GASTR NUTR
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NR 28
TC 9
Z9 10
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD MAY
PY 2021
VL 56
IS 5
BP 944
EP 950
DI 10.1016/j.jpedsurg.2020.12.002
EA MAY 2021
PG 7
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA SA9PS
UT WOS:000649635700021
PM 33342604
DA 2026-07-24
ER
PT J
AU Miura, T
   Yamamoto, Y
   Murao, N
   Maeda, T
   Osawa, M
   Hayashi, T
   Funayama, E
AF Miura, Takahiro
   Yamamoto, Yuhei
   Murao, Naoki
   Maeda, Taku
   Osawa, Masayuki
   Hayashi, Toshihiko
   Funayama, Emi
TI Combined internal and external negative pressure wound therapy:
   breakthrough treatment for lymphocutaneous intractable fistula
SO SURGERY TODAY
LA English
DT Article
DE Lymph node dissection; Lymphocutaneous fistula; Negative pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; GROIN
AB Purpose Lymphocutaneous fistula after lymph node dissection is intractable, yet there is no established treatment strategy. This study demonstrates the wound closure time achieved by a new method of combined internal and external negative pressure wound therapy (CIEN) in patients with lymphocutaneous fistula. Methods The subjects of this study were six consecutive patients with lymphocutaneous fistula after lymphatic surgery, who were treated with CIEN between 2018 and 2020. The CIEN technique can be summarized as follows: first, internal foam is inserted into the fistula from the opening of the fenestration. Next, a slightly larger area of external foam is applied above the fistula flap outside the external margin of the foam-filled fistula. After bridging the internal foam and external foam, negative-pressure wound therapy is carried out on this bridging foam block. Results CIEN led to rapid and complete wound healing in all six patients. Fistula flap margin ischemia developed in one patient, but adjusting the mode and pressure settings resulted in improvement. Three patients suffered contact dermatitis. There were no signs of tumor or fistula recurrence in any patients after at least 3 months of follow-up. Conclusion CIEN is an effective and less invasive treatment modality than the conventional method of managing lymphocutaneous fistula.
C1 [Miura, Takahiro; Yamamoto, Yuhei; Murao, Naoki; Maeda, Taku; Osawa, Masayuki; Hayashi, Toshihiko; Funayama, Emi] Hokkaido Univ, Fac Med, Dept Plast & Reconstruct Surg, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan.
   [Miura, Takahiro; Yamamoto, Yuhei; Murao, Naoki; Maeda, Taku; Osawa, Masayuki; Hayashi, Toshihiko; Funayama, Emi] Hokkaido Univ, Grad Sch Med, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan.
C3 Hokkaido University; Hokkaido University
RP Funayama, E (通讯作者)，Hokkaido Univ, Fac Med, Dept Plast & Reconstruct Surg, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan.; Funayama, E (通讯作者)，Hokkaido Univ, Grad Sch Med, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan.
EM emi-f@bc.iij4u.or.jp
OI MAEDA, TAKU/0000-0003-3612-8201; Miura, Takahiro/0000-0003-4180-6556
CR Abai B, 2007, J VASC SURG, V45, P610, DOI 10.1016/j.jvs.2006.10.043
   Andrews BT, 2006, LARYNGOSCOPE, V116, P1918, DOI 10.1097/01.mlg.0000235935.07261.98
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   Willy C, 2006, EXPT BASIS I REV LIT, P267
NR 20
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD OCT
PY 2021
VL 51
IS 10
BP 1630
EP 1637
DI 10.1007/s00595-021-02283-9
EA MAY 2021
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA US1OZ
UT WOS:000651016100001
PM 33993364
DA 2026-07-24
ER
PT J
AU Alipour, V
   Rezapour, A
   Ebrahimi, M
   Arabloo, J
AF Alipour, Vahid
   Rezapour, Aziz
   Ebrahimi, Mehdi
   Arabloo, Jalal
TI Cost-Utility Analysis of Negative Pressure Wound Therapy Compared With
   Traditional Wound Care in the Treatment of Diabetic Foot Ulcers in Iran
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE cost-utility analysis; negative pressure wound therapy; traditional
   wound care; diabetic foot ulcer
ID VACUUM-ASSISTED CLOSURE; DRESSINGS
AB Introduction. Negative pressure wound therapy (NPWT; also known as vacuum-assisted wound closure) has emerged as a promising option that may result in better health outcomes. Objective. This study analyzed the cost-utility of NPWT compared with traditional wound care (TWC) for the treatment of patients with diabetic foot ulcers in Iran from the perspective of health care providers. Materials and Methods. This economic evaluation study was conducted in 2016 to estimate the incremental cost effectiveness ratio of NPWT compared with TWC. The Markov model was applied, incorporating the 7 health states of uninfected, infected, infected post-amputation, healed, healed postamputation, amputation, and death for a 1-year time period and monthly cycles (12 cycles). Quality-adjusted life years (QALYs) were calculated from utility weights of each diagnosis, which were derived from the published literature. Costs for each diagnosis were estimated monthly and separately based on inpatient and outpatient care. The analysis of cost-effectiveness and sensitivity for uncertain parameters was carried out using TreeAge Pro 2011 software. Results. A total of 200 patient records (NPWT = 100; TWC = 100) were analyzed in this study. The results indicated that annual cost per patient for NPWT and TWC strategies were $5165 +/- $3258 and $9833 +/- $5861, respectively. In addition, mean effectiveness per patient per year for NPWT and TWC strategies were 8.9026 +/- 1.7622 and 8.7974 +/- 1.855 QALYs, respectively. When treatment with NPWT was compared with TWC using the incremental cost-effectiveness ratio of -$44 370 per QALY, NPWT was shown as a more cost-effective treatment strategy than TWC. Conclusions. The results of the study show that NPWT is less costly and more effective compared with TWC. In addition, NPWT reduces the number of amputations and increases the number of healed wounds, decreasing patients' and payers' costs. The sensitivity analysis of parameters proved the robustness of the Markov model.
C1 [Alipour, Vahid; Rezapour, Aziz; Arabloo, Jalal] Iran Univ Med Sci, Hlth Management & Econ Res Ctr, Tehran 1996713883, Tehran, Iran.
   [Ebrahimi, Mehdi] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Iran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Arabloo, J (通讯作者)，Iran Univ Med Sci, Hlth Management & Econ Res Ctr, Tehran 1996713883, Tehran, Iran.
EM arabloo_j64@yahoo.com
RI Alipour, Vahid/K-5099-2019; rezapour, aziz/M-2817-2018; arabloo,
   Jalal/K-1829-2019
OI arabloo, Jalal/0000-0003-1223-4528
FU Iran National Institute of Health Research, Tehran University of Medical
   Sciences [93264]
FX This study was funded and supported by Iran National Institute of Health
   Research, Tehran University of Medical Sciences; Grant No: 93264.
CR Alipour V, 2014, IRAN J RADIOL, V11, DOI 10.5812/iranjradiol.18738
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NR 31
TC 6
Z9 8
U1 2
U2 13
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2021
VL 33
IS 2
BP 50
EP 56
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SD0QB
UT WOS:000651066300006
PM 33591928
DA 2026-07-24
ER
PT J
AU Hurd, T
   Kirsner, RS
   Sancho-Insenser, JJ
   Fumarola, S
   Garten, A
   Patel, M
   Messinger, LM
   Diaz-Garcia, RJ
AF Hurd, Theresa
   Kirsner, Robert S.
   Sancho-Insenser, Joan J.
   Fumarola, Sian
   Garten, Alison
   Patel, Munir
   Messinger, Leta McCarty
   Diaz-Garcia, Rafael J.
TI International Consensus Panel Recommendations for the Optimization of
   Traditional and Single-Use Negative Pressure Wound Therapy in the
   Treatment of Acute and Chronic Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE traditional negative pressure wound therapy; single-use negative
   pressure wound therapy; patient satisfaction; quality of life;
   operational efficiencies; financial efficiencies
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS; CARE; GUIDELINES; MANAGEMENT;
   TRAUMA; ULCERS; NPWT
AB Introduction. Currently, there are no international standardized guidelines or recommendations to guide the clinical decision-making process on when to initiate various negative pressure wound therapy (NPWT) systems for acute and chronic wounds. Specifically, no established recommendations or guidance exists regarding the type of NPWT system to use, traditional (tNPWT) or single-use (sNPWT), and how to transition between the 2 systems. Methods. An expert panel was convened to (1) provide recommendations to clinicians on when to consider NPWT use in acute and chronic wound management and (2) develop a practical decision-making tool to guide on the appropriateness of the different NPWT modalities (tNPWT or sNPWT) and when they should be utilized. Results. The panel made recommendations and designed a clinical decision-making tool to aid the consideration for initiating NPWT and the optimal system to be utilized based on (1) therapeutic goals, (2) wound-related factors, (3) patient satisfaction and quality of life, (4) care setting-related factors, (5) economic-related factors, and (6) NPWT system-related factors. Conclusions. The panel recommendations took into consideration the clinical, operational, and financial factors in the clinical decision-making process of NPWT use to enable optimal patient and health care system outcomes.
C1 [Hurd, Theresa] Catholic Hlth Syst, Kenmore, NY USA.
   [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
   [Sancho-Insenser, Joan J.] Univ Autonoma Barcelona, Barcelona, Spain.
   [Fumarola, Sian] Univ Hosp North Midlands NHS Trust, Mid Staffordshire, England.
   [Garten, Alison] Piedmont Med Ctr, Charlotte, NC USA.
   [Patel, Munir] Mt Sinai Hlth Syst, New York, NY USA.
   [Messinger, Leta McCarty] Community Hosp Monterey Peninsula, Monterey, CA USA.
   [Diaz-Garcia, Rafael J.] Univ Pittsburgh, Allegheny Hlth Network, Sch Med, Pittsburgh, PA USA.
C3 University of Miami; Autonomous University of Barcelona; Icahn School of
   Medicine at Mount Sinai; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Allegheny Health Network
RP Hurd, T (通讯作者)，Care of Marmolejo V, Scriptum Med, University Pl, WA 98466 USA.
RI Diaz-Garcia, Rafael/JGD-0932-2023
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NR 49
TC 15
Z9 15
U1 1
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2021
VL 33
SU 2
BP S1
EP S9
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SD0QL
UT WOS:000651067300001
PM 33591931
DA 2026-07-24
ER
PT J
AU Kadota, H
   Miyashita, K
   Fukushima, S
   Oryoji, C
   Hanada, M
   Yoshida, S
   Fujita, H
   Tachibana, Y
AF Kadota, Hideki
   Miyashita, Kayo
   Fukushima, Seita
   Oryoji, Chikafumi
   Hanada, Masuo
   Yoshida, Sei
   Fujita, Hayato
   Tachibana, Yukiko
TI Successful Management of a Severe Sacral Pressure Injury Penetrating to
   the Retroperitoneum
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE debridement; negative pressure wound therapy; pemphigus; pressure
   injury; retroperitoneal space
ID IRRIGATION; ABSCESSES
AB Introduction. Reports of retroperitoneal infection related to a sacral pressure injury (PI) are rare, and none of the reports described the direct spread of infection through the sacrum to the retroperitoneum. The authors present, to their knowledge, the first report of a severely infected PI that showed full-thickness sacral destruction and direct retroperitoneal penetration. Case Report. A 63-year-old female was referred for management of a stage 4 sacral PI complicated by a retroperitoneal abscess. The patient's comorbidities were diabetes mellitus and pemphigus foliaceus with steroid therapy-induced immunosuppression. Upon admission, the patient presented with a sacral PI producing copious purulent discharge that measured 5 cm x 3 cm. Magnetic resonance imaging revealed full-thickness sacral bone destruction and a massive retroperitoneal abscess, suggesting the sacral PI directly penetrated to the retroperitoneal space. Antibiotics were administered, and surgical debridement and sequestrectomy were performed. Negative pressure wound therapy (NPWT) with continuous saline irrigation was initiated. The patient's mesorectum was exposed within the retroperitoneal space. Therefore, a nonadhesive wound dressing was applied before placing the irrigation tube to avoid perforating the rectum. Because the patient had fragile skin secondary to long- standing pemphigus foliaceus and steroid treatment, a liquid skin protectant and hydrocolloid wound dressing were applied. The infection was successfully controlled with NPWT with saline irrigation. The patient experienced no rectal injury or skin rupture, and surgical closure was performed after 75 days. Although partial wound dehiscence occurred because of the poor condition of the skin, the resultant open wound was managed conservatively. The patient showed no retroperitoneal abscess recurrence 6 months later. Conclusions. A rare case of an intractable sacral PI complicated by retroperitoneal abscess was successfully managed in an immunocompromised patient. Notably, NPWT with saline irrigation was useful in controlling the patient's severe retroperitoneal infection.
C1 [Kadota, Hideki; Miyashita, Kayo; Fukushima, Seita; Oryoji, Chikafumi; Hanada, Masuo; Yoshida, Sei] Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, Fukuoka, Japan.
   [Fujita, Hayato] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Fukuoka, Japan.
   [Tachibana, Yukiko] Kyushu Univ, Grad Sch Med Sci, Div Pressure Ulcer Prevent, Fukuoka, Japan.
C3 Kyushu University; Kyushu University; Kyushu University
RP Kadota, H (通讯作者)，3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan.
EM kadohide@qent.med.kyushu-u.ac.jp
RI /AAU-7710-2020
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NR 15
TC 0
Z9 1
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2021
VL 33
IS 3
BP E24
EP E27
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SD0QQ
UT WOS:000651067900002
PM 33914698
DA 2026-07-24
ER
PT J
AU Doval, AF
   Chegireddy, V
   Beal, L
   Arroyo-Alonso, C
   Zavlin, D
   Spiegel, AJ
   Ellsworth, WA
AF Doval, Andres F.
   Chegireddy, Vishwanath
   Beal, Lauren
   Arroyo-Alonso, Christian
   Zavlin, Dmitry
   Spiegel, Aldona J.
   Ellsworth, Warren A.
TI Efficacy of Closed Incision Negative Pressure Wound Therapy on Abdominal
   Donor Site After Free Flap Breast Reconstruction
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE closed incision negative pressure wound therapy; DIEP flap; donor site;
   surgical
ID RISK-FACTORS; DIEP FLAPS; COMPLICATIONS; MASTECTOMY; PREVENTION;
   MANAGEMENT; WOMEN
AB Introduction. Negative pressure wound therapy (NPWT) has been used to treat acute and chronic wounds in a variety of scenarios. Specifically, in autologous breast reconstruction, studies investigating the use of closed incision NPWT (ciNPWT) in breast surgery are lacking. Objective. The aim of this study was to analyze the use of ciNPWT at the abdominal donor site following deep inferior epigastric perforator (DIEP) flap breast reconstruction. Materials and Methods. A retrospective cohort study was conducted over a 15-month period including patients who underwent abdominally based microsurgical breast reconstruction. Patients were divided into 2 groups: (1) a control group that underwent standard abdominal donor site closure and (2) an experimental group that underwent standard abdominal donor site closure plus ciNPWT. Groups were compared in terms of demographic characteristics, perioperative variables, and abdominal donor site complications. Results. A total of 42 patients were identified. Of these, 18 were included in the control group and 24 in the ciNPWT group. No cases of seroma, abdominal bulge, or abdominal hernia were reported. Wound dehiscence developed in 2 patients (11.1%) in the control group and in 3 patients (12.5%) in the experimental group (P = 1.000). One patient (5.6%) in the control group had an infection of the donor site compared with none in the ciNPWT group (P = .429). Interestingly, 3 patients developed hyperpigmentation where the ciNPWT plastic drape was placed. Conclusions. The use of ciNPWT on the abdominal donor site following DIEP flap breast reconstruction did not lower the incidence of wound dehiscence and wound infection. Different approaches are needed to decrease the incidence of donor site complications in abdominally based postmastectomy breast reconstruction.
C1 [Doval, Andres F.; Chegireddy, Vishwanath; Beal, Lauren; Arroyo-Alonso, Christian; Zavlin, Dmitry; Spiegel, Aldona J.; Ellsworth, Warren A.] Houston Methodist Hosp, Inst Reconstruct Surg, Weill Cornell Med, Houston, TX USA.
C3 Houston Methodist
RP Ellsworth, WA (通讯作者)，Methodist West Houston Hosp, Inst Reconstruct Surg, 18400 Katy Freeway,Suite 500, Houston, TX 77094 USA.
EM WAEllsworth@houstonmethodist.org
OI spiegel, Aldona/0000-0002-8040-320X
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NR 29
TC 16
Z9 17
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2021
VL 33
IS 4
BP 81
EP 85
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SD0QW
UT WOS:000651068500004
PM 33872200
DA 2026-07-24
ER
PT J
AU Gillespie, BM
   Webster, J
   Ellwood, D
   Thalib, L
   Whitty, JA
   Mahomed, K
   Clifton, V
   Kumar, S
   Wagner, A
   Kang, E
   Chaboyer, W
AF Gillespie, Brigid M.
   Webster, Joan
   Ellwood, David
   Thalib, Lukman
   Whitty, Jennifer A.
   Mahomed, Kassam
   Clifton, Vicki
   Kumar, Sailesh
   Wagner, Adam
   Kang, Evelyn
   Chaboyer, Wendy
TI Closed incision negative pressure wound therapy versus standard
   dressings in obese women undergoing caesarean section: multicentre
   parallel group randomised controlled trial
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Article
ID SURGICAL SITE INFECTION
AB OBJECTIVE To determine the effectiveness of closed incision negative pressure wound therapy (NPWT) compared with standard dressings in preventing surgical site infection (SSI) in obese women undergoing caesarean section. DESIGN Multicentre, pragmatic, randomised, controlled, parallel group, superiority trial. SETTING Four Australian tertiary hospitals between October 2015 and November 2019. PARTICIPANTS Eligible women had a pre-pregnancy body mass index of 30 or greater and gave birth by elective or semi-urgent caesarean section. INTERVENTION 2035 consenting women were randomised before the caesarean procedure to closed incision NPWT (n=1017) or standard dressing (n=1018). Allocation was concealed until skin closure. MAIN OUTCOME MEASURES The primary outcome was cumulative incidence of SSI. Secondary outcomes included depth of SSI (superficial, deep, or organ/body space), rates of wound complications (dehiscence, haematoma, seroma, bleeding, bruising), length of stay in hospital,
C1 [Gillespie, Brigid M.; Kang, Evelyn; Chaboyer, Wendy] Griffith Univ, Menzies Hlth Inst, Ctr Res Excellence Wiser Wound Care, Natl Hlth & Med Res Council, Gold Coast, Qld, Australia.
   [Gillespie, Brigid M.; Ellwood, David] Gold Coast Univ Hosp, Gold Coast Hlth, Southport, Qld, Australia.
   [Webster, Joan] Royal Brisbane & Womens Hosp, Ctr Clin Nursing, Herston, Qld, Australia.
   [Ellwood, David] Griffith Univ, Sch Med & Dent, Gold Coast, Qld, Australia.
   [Thalib, Lukman] Griffith Univ, Sch Nursing & Midwifery, Gold Coast, Qld, Australia.
   [Whitty, Jennifer A.; Kang, Evelyn] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
   [Whitty, Jennifer A.; Wagner, Adam] Natl Inst Hlth Res, Appl Res Collaborat ARC, East England EoE, Norwich, Norfolk, England.
   [Mahomed, Kassam] Ipswich Hosp, West Moreton Hlth, Ipswich, Qld, Australia.
   [Clifton, Vicki; Kumar, Sailesh] Univ Queensland, Mater Res Inst, South Brisbane, Qld, Australia.
   [Kumar, Sailesh] Mater Mothers Hosp, South Brisbane, Qld, Australia.
C3 Griffith University; Menzies Health Institute Queensland; Gold Coast
   Health; Gold Coast University Hospital; Royal Brisbane & Women's
   Hospital; Griffith University; Griffith University; University of East
   Anglia; University of Queensland; Mater Research; Mater Health Services;
   Mater Mothers' Hospital
RP Gillespie, BM (通讯作者)，Griffith Univ, Menzies Hlth Inst, Ctr Res Excellence Wiser Wound Care, Natl Hlth & Med Res Council, Gold Coast, Qld, Australia.; Gillespie, BM (通讯作者)，Gold Coast Univ Hosp, Gold Coast Hlth, Southport, Qld, Australia.
EM b.gillespie@griffith.edu.au
RI Whitty, Jennifer/N-6434-2013; Thalib, Lukman/HAI-7553-2022; Chaboyer,
   Wendy/F-9588-2018; Ellwood, David/C-8208-2015; Mahomed,
   Kassam/M-1335-2013; Wagner, Adam/AAA-4346-2019; Gillespie,
   Brigid/E-7799-2012; Clifton, Vicki L/AAV-2749-2021
OI Thalib, Lukman/0000-0002-1211-6495; Chaboyer, Wendy/0000-0001-9528-7814;
   Ellwood, David/0000-0003-4512-6443; Wagner, Adam/0000-0002-9101-3477;
   Gillespie, Brigid/0000-0003-3186-5691; Kang, Evelyn/0000-0001-8253-1638;
   Clifton, Vicki L/0000-0002-4892-6748
FU Australian National Health and Medical Research Council [APP1081026]
FX The trial was funded by a competitive peer reviewed grant (APP1081026)
   from the Australian National Health and Medical Research Council. The
   funders had no role in considering the study design or in the
   collection, analysis, or interpretation of data, the writing of the
   report, or the decision to submit the article for publication. The views
   expressed are those of the authors and not necessarily those of the NHS,
   the National Institute for Health Research (NIHR) , or the Department of
   Health and Social Care.
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NR 29
TC 32
Z9 36
U1 0
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD MAY 5
PY 2021
VL 373
AR bmj
DI 10.1136/bmj.n893
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SD2YX
UT WOS:000651241900014
PM 33952438
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hawthorne, B
   Simmons, JK
   Stuart, B
   Tung, R
   Zamierowski, DS
   Mellott, AJ
AF Hawthorne, Briauna
   Simmons, J. Kai
   Stuart, Braden
   Tung, Robert
   Zamierowski, David S.
   Mellott, Adam J.
TI Enhancing wound healing dressing development through interdisciplinary
   collaboration
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Review
DE biomedical engineering; interdisciplinary teams; negative pressure wound
   therapy; wound dressings; wound healing
ID IN-VITRO; HYDROGEL; SCAFFOLDS; THERAPY; CLOSURE; REPAIR; BURNS
AB The process of wound healing includes four phases: Hemostasis, inflammation, proliferation, and remodeling. Many wound dressings and technologies have been developed to enhance the body's ability to close wounds and restore the function of damaged tissues. Several advancements in wound healing technology have resulted from innovative experiments by individual scientists or physicians working independently. The interplay between the medical and scientific research fields is vital to translating new discoveries in the lab to treatments at the bedside. Tracing the history of wound dressing development reveals that there is an opportunity for deeper collaboration between multiple disciplines to accelerate the advancement of novel wound healing technologies. In this review, we explore the different types of wound dressings and biomaterials used to treat wounds, and we investigate the role of multidisciplinary collaboration in the development of various wound management technologies to illustrate the benefit of direct collaboration between physicians and scientists.
C1 [Hawthorne, Briauna; Simmons, J. Kai; Stuart, Braden; Tung, Robert; Zamierowski, David S.; Mellott, Adam J.] Univ Kansas, Dept Plast Surg, Med Ctr, Mail Stop 3051 3901 Rainbow Blvd, Kansas City, KS 66160 USA.
C3 University of Kansas; University of Kansas Medical Center
RP Mellott, AJ (通讯作者)，Univ Kansas, Dept Plast Surg, Med Ctr, Mail Stop 3051 3901 Rainbow Blvd, Kansas City, KS 66160 USA.
EM amellott@kumc.edu
RI Mellott, AJ/HOF-9580-2023
OI Mellott, AJ/0000-0002-7545-3763
FU R3 lab
FX Authors would like to sincerely thank the entire R3 lab for their
   support, feedback, and encouragement.
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NR 181
TC 61
Z9 72
U1 4
U2 78
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD DEC
PY 2021
VL 109
IS 12
BP 1967
EP 1985
DI 10.1002/jbm.b.34861
EA MAY 2021
PG 19
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA WA7HX
UT WOS:000651299000001
PM 34002476
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Nherera, LM
   Saunders, C
   Verma, S
   Trueman, P
   Fatoye, F
AF Nherera, Leo M.
   Saunders, Chris
   Verma, Sanjay
   Trueman, Paul
   Fatoye, Francis
TI Single-use negative pressure wound therapy reduces costs in closed
   surgical incisions: UK and US economic evaluation
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE closed surgical incisions; cost-effectiveness; diabetes; dressing;
   single-use negative pressure wound therapy; surgical site complications;
   wound; wound healing
ID SITE INFECTION; RISK-FACTORS; OUTCOMES; SURGERY; BYPASS; HEALTH; IMPACT;
   CARE
AB Objective: Single-use negative pressure wound therapy (sNPWT) following closed surgical incisions has a demonstrable effect in reducing surgical site complications (SSC). However, there is little health economic evidence to support its widespread use. We sought to evaluate the cost-effectiveness of sNPWT compared with standard care in reducing SSCs following closed surgical incisions.
   Method: A decision analytic model was developed to explore the total costs and health outcomes associated with the use of the interventions in patients following vascular, colorectal, cardiothoracic, orthopaedic, C-section and breast surgery from the UK National Health Service (NHS) and US payer perspective over a 12-week time horizon. We modelled complications avoided (surgical site infection (SSI) and dehiscence) using data from a recently published metaanalysis. Cost data were sourced from published literature, NHS reference costs and Centers for Medicare and Medicaid Services. We conducted subgroup analysis of patients with diabetes, an American Society of Anesthesiologists (ASA) score >= 3 and body mass index BMI) >= 30kg/m(2). A sensitivity analysis was also conducted.
   Results: sNPWT resulted in better clinical outcomes and overall savings of 105 pound per patient from the UK perspective and $637 per patient from the US perspective. There were more savings when higher-risk patients with diabetes, or a BMI >= 30kg/m(2) or an ASA >= 3 were considered. We conducted both one-way and probabilistic sensitivity analysis, and the results suggested that this conclusion is robust.
   Conclusion: Our findings suggest that the use of sNPWT following closed surgical incisions saves cost when compared with standard care because of reduced incidence of SSC. Patients at higher risk should be targeted first as they benefit more from sNPWT. This analysis is underpinned by strong and robust clinical evidence from both randomised and observational studies. Declaration of interest: LN, CS, SV and PT are employees of Smith + Nephew Inc., and may own shares of Smith + Nephew. FF is a consultant of Smith + Nephew.
C1 [Nherera, Leo M.] Smith Nephew, Ft Worth, TX 76109 USA.
   [Saunders, Chris; Trueman, Paul] Smith Nephew, Global Clin Affairs, Kingston Upon Hull, N Humberside, England.
   [Verma, Sanjay] Smith Nephew, Global Biostat, Watford, England.
   [Fatoye, Francis] Manchester Metropolitan Univ, Hlth Econ & Outcomes, Manchester, Lancs, England.
C3 Smith & Nephew; Smith & Nephew; Manchester Metropolitan University
RP Nherera, LM (通讯作者)，Smith Nephew, Ft Worth, TX 76109 USA.
EM leo.nherera@smith-nephew.com
OI Fatoye, Francis/0000-0002-3502-3953
CR [Anonymous], MED B
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NR 40
TC 12
Z9 16
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2021
VL 30
IS 5
SU S
BP S23
EP S31
DI 10.12968/jowc.2021.30.Sup5.S23
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA SD8HQ
UT WOS:000651616700005
PM 33979232
DA 2026-07-24
ER
PT J
AU Allen, P
   Pugh, J
   Blau, A
AF Allen, Pete
   Pugh, Jackson
   Blau, Alexander
TI Case Study: Acute Lumbar Paraspinal Compartment Syndrome in an Austere
   Military Environment
SO MILITARY MEDICINE
LA English
DT Article
AB The incidence of compartment syndrome of the lumbar paraspinal muscles is exceedingly rare. Approximately 24 hours following a high-intensity kettlebell swing workout, a 33-year-old Sailor presented to the medical department on board a forward deployed Wasp-class amphibious assault ship with increasing discomfort in his middle and lower back, and evidence of rhabdomyolysis. Discomfort quickly turned to unrelenting pain coupled with dorsal paresthesias and rigidity in the paraspinal muscles. He was taken emergently to the operating room, where his paraspinal muscles were released via fasciotomy. As a result of limited resources aboard the deployed ship, a negative pressure wound dressing was fashioned using the supplies available aboard the ship. Following 3 days of the negative pressure wound therapy, muscle bulging decreased substantially, and the skin was closed. After 4 weeks of physical therapy, he returned to full duty.
C1 [Allen, Pete; Pugh, Jackson; Blau, Alexander] US Fleet Forces Command, Dept Navy, Norfolk, VA 23551 USA.
RP Allen, P (通讯作者)，US Fleet Forces Command, Dept Navy, Norfolk, VA 23551 USA.
OI Blau, Alexander/0000-0002-6132-598X
CR Jaworski RL, 2015, MIL MED, V180, P179, DOI 10.7205/MILMED-D-14-00432
   Khan RJK, 2005, J BONE JOINT SURG AM, V87A, P1126, DOI 10.2106/JBJS.D.02133
   Kitajima I, 2002, AM J SPORT MED, V30, P283, DOI 10.1177/03635465020300022301
   Knox J, 2011, SPINE, V36, P1492, DOI 10.1097/BRS.0b013e3181f40ddd
   Nathan ST, 2012, INT ORTHOP, V36, P1221, DOI 10.1007/s00264-011-1386-4
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   Waterman BR, 2013, AM J SPORT MED, V41, P2545, DOI 10.1177/0363546513497922
NR 7
TC 1
Z9 3
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN-FEB
PY 2021
VL 186
IS 1-2
BP 254
EP 257
DI 10.1093/milmed/usaa382
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SE1HS
UT WOS:000651826400055
PM 33128551
OA hybrid
DA 2026-07-24
ER
PT J
AU Seaman, AP
   Sarac, BA
   ElHawary, H
   Janis, JE
AF Seaman, A. P.
   Sarac, B. A.
   ElHawary, H.
   Janis, J. E.
TI The effect of negative pressure wound therapy on surgical site
   occurrences in closed incision abdominal wall reconstructions: a
   retrospective single surgeon and institution study
SO HERNIA
LA English
DT Article
DE Closed incision negative pressure wound therapy
ID MANAGEMENT; EVENTS; REPAIR
AB Purpose The use of closed incision negative pressure wound therapy (ciNPWT) in abdominal wall reconstruction is heavily debated. The current literature shows mixed results for its efficacy in preventing surgical site occurrences (SSOs), and many of the studies are limited by small sample size or a lack of generalizability. We sought to assess whether the use of prophylactic ciNPWT has an effect on reducing the rate of SSOs. Methods Following institutional review board approval, a retrospective analysis of a prospectively collected abdominal wall reconstruction database of a single surgeon at a single institution was completed. Two hundred and seventy patients were reviewed. Univariate and multivariate logistic regressions were performed to assess the effect of each variable on the rate of SSOs. Results Two hundred and fifty-eight patients (95.56%) met inclusion criteria. One hundred and fifty-nine (61.63%) of these patients received ciNPWT. The median duration of ciNPWT was 6 days. Multivariate logistic regression analysis showed no significant difference in the prevalence of SSOs between groups (OR = 0.843, 95% CI [0.445-1.594], p = 0.598). It did, however, show a significant decrease in the rates of seroma (7.07% vs. 0.63%, p = 0.004). Moreover, skin resection was associated with a decreased rate of SSO (OR = 0.295, 95% CI [0.096-0.911], p = 0.034). Conclusions ciNPWT was not associated with a decrease in SSOs following abdominal wall reconstruction but did show a statistically significant decrease in postoperative seromas. Future, large prospective analyses may help further discover the utility of ciNPWT in reducing SSOs.
C1 [Seaman, A. P.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
   [ElHawary, H.] McGill Univ, Div Plast & Reconstruct Surg, Montreal, PQ, Canada.
   [Sarac, B. A.; Janis, J. E.] Ohio State Univ, Dept Plast & Reconstruct Surg, Wexner Med Ctr, 915 Olentangy River Rd,Suite 2100, Columbus, OH 43212 USA.
C3 University System of Ohio; Ohio State University; McGill University;
   University System of Ohio; Ohio State University
RP Janis, JE (通讯作者)，Ohio State Univ, Dept Plast & Reconstruct Surg, Wexner Med Ctr, 915 Olentangy River Rd,Suite 2100, Columbus, OH 43212 USA.
EM Jeffrey.janis@osumc.edu
RI Janis, Jeffrey/W-6760-2019
OI Janis, Jeffrey/0000-0001-6103-4798; Seaman, Austin/0000-0002-3454-268X;
   Sarac, Benjamin/0000-0001-7825-4957; ElHawary,
   Hassan/0000-0003-4542-5814
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NR 30
TC 9
Z9 11
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD DEC
PY 2021
VL 25
IS 6
BP 1549
EP 1555
DI 10.1007/s10029-021-02427-3
EA MAY 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XC8RX
UT WOS:000652093500002
PM 34009506
DA 2026-07-24
ER
PT J
AU Othman, SA
   ElSharkawy, TM
   Alfaifi, D
   Aljehani, Y
AF Othman, Sharifah A.
   ElSharkawy, Tarek M.
   Alfaifi, Doaa
   Aljehani, Yasser
TI The Effectiveness of Vacuum-Assisted Closure Device in Managing
   Intramuscular Tuberculosis
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE cutaneous; empyema necessitans; intramuscular; negative-pressure wound
   therapy; tuberculosis
ID MANAGEMENT
AB Tuberculosis (TB) is endemic to some geographic areas such as Africa, Eastern Europe, Asia, Latin America, and the Caribbean. It is called the great mimicker because of its diverse and variable presentation and affects almost every organ in the body with different symptomatology. Often, TB causes empyema necessitans, the rarest forms of which are intramuscular and cutaneous. Here, the authors report a case of empyema necessitans and intramuscular TB, which was managed successfully with negative-pressure wound therapy. The treatment provided a good outcome and patient satisfaction compared with traditional invasive surgical options.
C1 [Othman, Sharifah A.; Aljehani, Yasser] Imam Abdulrahman Bin Faisal Univ, King Fahad Hosp, Coll Med, Thorac Surg Div, Dammam, Saudi Arabia.
   [ElSharkawy, Tarek M.; Alfaifi, Doaa] Imam Abdulrahman Bin Faisal Univ, King Fahad Hosp, Coll Med, Pathd Dept, Dammam, Saudi Arabia.
C3 Imam Abdulrahman Bin Faisal University; Imam Abdulrahman Bin Faisal
   University
RP Othman, SA (通讯作者)，Imam Abdulrahman Bin Faisal Univ, King Fahad Hosp, Coll Med, Thorac Surg Div, Dammam, Saudi Arabia.
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NR 8
TC 1
Z9 1
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUN
PY 2021
VL 34
IS 6
BP 330
EP 333
DI 10.1097/01.ASW.0000744328.95568.20
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA SE5ZF
UT WOS:000652149700015
PM 33958522
DA 2026-07-24
ER
PT J
AU Ayuso, SA
   Elhage, SA
   Aladegbami, BG
   Kao, AM
   Kercher, KW
   Colavita, PD
   Augenstein, VA
   Heniford, BT
AF Ayuso, Sullivan A.
   Elhage, Sharbel A.
   Aladegbami, Bola G.
   Kao, Angela M.
   Kercher, Kent W.
   Colavita, Paul D.
   Augenstein, Vedra A.
   Heniford, B. Todd
TI Delayed primary closure (DPC) of the skin and subcutaneous tissues
   following complex, contaminated abdominal wall reconstruction (AWR): a
   propensity-matched study
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Delayed primary closure; Contaminated; Hernia; Abdominal wall
   reconstruction; Complication; Surgical site occurrence; Infection;
   Negative pressure wound therapy
ID VENTRAL HERNIA REPAIR; SURGICAL SITE INFECTION; PRESSURE WOUND THERAPY;
   CAROLINAS EQUATION; RECURRENCE; OUTCOMES; DEFECTS; SCORE; COST; CARE
AB Background Wound complications following abdominal wall reconstruction (AWR) in a contaminated setting are common and significantly increase the risk of hernia recurrence. The purpose of this study was to examine the effect of short-term negative pressure wound therapy (NPWT) followed by operative delayed primary closure (DPC) of the skin and subcutaneous tissue after AWR in a contaminated setting. Methods A prospective institutional hernia database was queried for patients who underwent NPWT-assisted DPC after contaminated AWR between 2008 and 2020. Primary outcomes included wound complication rate and reopening of the incision. A non-DPC group was created using propensity-matching. Standard descriptive statistics were used, and a univariate analysis was performed between the DPC and non-DPC groups. Results In total, 110 patients underwent DPC following AWR. The hernias were on average large (188 +/- 133.6 cm(2)), often recurrent (81.5%), and 60.5% required a components separation. All patients had CDC Class 3 (14.5%) or 4 (85.5%) wounds and biologic mesh placed. Using CeDAR, the wound complication rate was estimated to be 66.3%. Postoperatively, 26.4% patients developed a wound complication, but only 5.5% patients required reopening of the wound. The rate of recurrence was 5.5% with mean follow-up of 22.6 +/- 27.1 months. After propensity-matching, there were 73 patients each in the DPC and non-DPC groups. DPC patients had fewer overall wound complications (23.0% vs 43.9%, p = 0.02). While 4.1% of the DPC group required reopening of the incision, 20.5% of patients in the non-DPC required reopening of the incision (p = 0.005) with an average time to healing of 150 days. Hernia recurrence remained low overall (2.7% vs 5.4%, p = 0.17). Conclusions DPC can be performed with a high rate of success in complex, contaminated AWR patients by reducing the rate of wound complications and avoiding prolonged healing times. In patients undergoing AWR in a contaminated setting, a NPWT-assisted DPC should be considered.
C1 [Ayuso, Sullivan A.; Elhage, Sharbel A.; Aladegbami, Bola G.; Kao, Angela M.; Kercher, Kent W.; Colavita, Paul D.; Augenstein, Vedra A.; Heniford, B. Todd] Carolinas Med Ctr, Dept Surg, Gastrointestinal & Minimally Invas Surg, 1025 Morehead Med Dr Suite 300, Charlotte, NC 28204 USA.
C3 Carolinas Medical Center
RP Heniford, BT (通讯作者)，Carolinas Med Ctr, Dept Surg, Gastrointestinal & Minimally Invas Surg, 1025 Morehead Med Dr Suite 300, Charlotte, NC 28204 USA.
EM todd.heniford@gmail.com
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NR 39
TC 16
Z9 17
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD MAR
PY 2022
VL 36
IS 3
BP 2169
EP 2177
DI 10.1007/s00464-021-08485-z
EA MAY 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ZA4UA
UT WOS:000652466800001
PM 34018046
DA 2026-07-24
ER
PT J
AU Fakhre, E
   Connors, KM
   Curley, AJ
   Argintar, EH
AF Fakhre, Edward
   Connors, Katherine M.
   Curley, Andrew J.
   Argintar, Evan H.
TI Outcomes of Prophylactic Negative Pressure Wound Therapy in
   Multiligament Knee Reconstruction
SO ORTHOPEDICS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; HIP; DRESSINGS; ANTERIOR
AB Negative pressure wound therapy (NPWT) has shown promise in reducing postoperative complications in several applications in orthopedic surgery, including trauma and arthroplasty. To the authors' knowledge, no study has evaluated its use in multiligament knee reconstruction. Multiligament knee reconstruction is often fraught with arthrofibrosis and wound-healing complications. This retrospective study assessed complications requiring reoperation in patients who underwent multiligament knee reconstruction and received either NPWT (n=14) or a dry sterile dressing (DSD) (n=44). There were significantly more reoperations in the cohort of patients who received a DSD (P=.011). Arthrofibrosis in particular showed a significantly lower rate of occurrence in the NPWT cohort compared with the DSD cohort (P=.025). There was a trend toward a lower infection rate in the NPWT cohort (P=.322). This study provides evidence that NPWT may be effective in reducing reoperation after multiligament knee reconstruction. Further investigations with prospective studies are needed to draw stronger conclusions about the benefits of NPWT.
C1 [Fakhre, Edward; Curley, Andrew J.] Medstar Georgetown Univ Hosp, Dept Orthoped, 3800 Reservoir Rd, Washington, DC 20007 USA.
   [Argintar, Evan H.] Medstar Washington Hosp Ctr, Dept Orthoped, Washington, DC USA.
   [Connors, Katherine M.] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA.
C3 Georgetown University; MedStar Washington Hospital Center; State
   University of New York (SUNY) System; SUNY Downstate Health Sciences
   University
RP Fakhre, E (通讯作者)，Medstar Georgetown Univ Hosp, Dept Orthoped, 3800 Reservoir Rd, Washington, DC 20007 USA.
EM edwardfakhre@gmail.com
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NR 18
TC 1
Z9 1
U1 0
U2 2
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD MAY-JUN
PY 2021
VL 44
IS 3
BP 187
EP 191
DI 10.3928/01477447-20210415-05
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA SH3UM
UT WOS:000654062300036
PM 34039213
DA 2026-07-24
ER
PT J
AU Pouzet, L
   Lancien, U
   Hamel, A
   Perrot, P
   Duteille, F
AF Pouzet, L.
   Lancien, U.
   Hamel, A.
   Perrot, P.
   Duteille, F.
TI Negative Pressure Wound Therapy in children: A 25 cases series
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA English
DT Article
DE Negative Pressure Wound Therapy; Pediatric surgery; Wound; NPWT; Plastic
   pediatric surgery
ID CLOSURE; INFECTIONS; MANAGEMENT; INFANTS
AB Negative Pressure Wound Therapy is a device applied to a wound that causes local depression. There are a few series showing the effectiveness of this treatment in Pediatric. The objective of this work is to try to clarify the indications in children. This is a retrospective series of 25 children between 2004 and 2019. The inclusion criteria were all children with a wound treated with Negative Pressure Wound Therapy. The characteristics retained were their age, the context of occurrence, the treatment time, the depression applied, the technique of skin covering wound and the average healing time. We included 25 patients. The average age was 8.8 years. The context of the wound occurrence was mainly a road (44%) or a domestic (36%) accident. Substance losses were mainly located in the lower limb (84%). The depression applied was -90 mmHg. The healing time was 18.4 days. Thin skin grafting was the main method chosen (88%). No complications related to Negative Pressure Wound Therapy equipment have been identified. Despite the weakness of the literature and the lack of consensus regarding its use, Negative Pressure Wound Therapy is an essential therapy in pediatric. It is a simple and effective technique in children. It can reduce the need for flaps coverage, even in the event of exposure of noble elements. The flaps should not, however, be excluded from the decision-making algorithm, on pain of complications or sequelae. (C) 2020 Elsevier Masson SAS. All rights reserved.
C1 [Pouzet, L.; Lancien, U.; Perrot, P.; Duteille, F.] CHU Nantes, Plast & Reconstruct Surg Dept, Burns Ctr, Hotel Dieu, 30 Blvd Jean Monnet, F-44093 Nantes 1, France.
   [Hamel, A.] CHU Nantes, Pediat Orthoped Dept, Hop Mere Enfant, 38 Blvd Jean Monnet, F-44093 Nantes 1, France.
   [Pouzet, L.] CHU Reims, Plast & Reconstruct Surg Dept, Hop Maison Blanche, 45 Rue Cognacq Jay, F-51092 Reims, France.
C3 Nantes Universite; CHU de Nantes; Nantes Universite; CHU de Nantes; CHU
   de Reims; Universite de Reims Champagne-Ardenne
RP Pouzet, L (通讯作者)，CHU Reims, Plast & Reconstruct Surg Dept, Hop Maison Blanche, 45 Rue Cognacq Jay, F-51092 Reims, France.
EM lpouzet@chu-reims.fr
RI Hamel, Antoine/AAH-7437-2020; Lancien, Ugo/PNE-8797-2026
OI Hamel, Antoine/0000-0003-3348-9060; Lancien, Ugo/0000-0003-1262-5510; 
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NR 33
TC 3
Z9 3
U1 0
U2 4
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
EI 1768-319X
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD JUN
PY 2021
VL 66
IS 3
BP 242
EP 249
DI 10.1016/j.anplas.2020.06.002
EA MAY 2021
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SH7YO
UT WOS:000654349700007
PM 32665064
DA 2026-07-24
ER
PT J
AU Faisal, M
   Berend, PD
   Seemann, R
   Janik, S
   Grasl, S
   Ritzengruber, A
   Mendel, H
   Jamshed, A
   Hussain, R
   Erovic, BM
AF Faisal, Muhammad
   Berend, Peter D.
   Seemann, Rudolf
   Janik, Stefan
   Grasl, Stefan
   Ritzengruber, Andrea
   Mendel, Herbert
   Jamshed, Arif
   Hussain, Raza
   Erovic, Boban M.
TI Impact of Previous Irradiation on Wound Healing after Negative Pressure
   Wound Therapy in Head and Neck Cancer Patients-A Systematic Review
SO CANCERS
LA English
DT Review
DE negative pressure wound therapy; head and neck cancers; radiation
   therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Simple Summary
   The study has focused on the use of Negative Pressure Wound Therapy (NPWT) specifically in head and neck cancer patients. The sole purpose of using NPWT is to expedite the process of healing as most of the head and neck cancer patients are bound to get post-operative radiotherapy and any delay would further lengthen the treatment and affect the outcome. Previous irradiation and Diabetes Mellitus have detrimental impact on wound healing after NPWT.
   (1) Background: Negative pressure wound therapy (NPWT) has been effectively used for wound management in comparison to traditional dressings. The purpose of this study was to provide an evidence-based review of NPWT in head and neck cancer patients, as well as the impact of previous irradiation and other risk factors on wound healing. (2) Material and Methods: We conducted a comprehensive search in PubMed, Medline, Embase, Web of Science, and Cochrane Library databases for relevant literature. (3) Results: 15 studies fulfilled the inclusion criteria. The most common etiologies requiring NPWT were defects post tumor resection and flap reconstruction and oro/pharyngo-cutaneous fistulas. The neck was found to be the most common site of involvement (47.3%). The overall wound healing response rate was 87.5%. The median negative pressure recorded was 125 mm of Hg, with a median dressing change time of three days. Previous irradiation (p = 0.01; OR = 4.07) and diabetes mellitus (DM) (p = 0.001; OR = 5.62) were found to be significantly associated with delayed wound healing after NPWT. (4) Conclusion: NPWT treats complex wounds in head and neck cancer patients and should represent a significant armamentarium in head and neck cancers. Previous irradiation and DM have detrimental effects on wound healing after NPWT.
C1 [Faisal, Muhammad; Seemann, Rudolf; Erovic, Boban M.] Evangel Hosp, Inst Head & Neck Dis, A-1180 Vienna, Austria.
   [Faisal, Muhammad; Jamshed, Arif; Hussain, Raza] Shaukat Khanum Mem Canc Hosp, Dept Head & Neck Surg, Lahore 54000, Pakistan.
   [Berend, Peter D.; Janik, Stefan; Grasl, Stefan] Med Univ Vienna, Dept Otolaryngol Head & Neck Surg, A-1090 Vienna, Austria.
   [Ritzengruber, Andrea] Evangelical Hosp, Wound Management, A-1180 Vienna, Austria.
   [Mendel, Herbert] Evangelical Hosp, Dept Gen Surg, A-1180 Vienna, Austria.
C3 Evangelisches Krankenhaus Vienna; Shaukat Khanum Memorial Cancer
   Hospital & Research Centre; Medical University of Vienna
RP Erovic, BM (通讯作者)，Evangel Hosp, Inst Head & Neck Dis, A-1180 Vienna, Austria.
EM maxfas@live.com; pdberend@gmail.com; rudolf.seemann@gmail.com;
   stefan.janik@meduniwien.ac.at; stefan.grasl@meduniwien.ac.at;
   a.ritzengruber@gmail.com; herbert.mendel@gmx.at; jamshedarif@gmail.com;
   razah@skm.org.pk; b.erovic@ekhwien.at
RI Erovic, Boban/S-7824-2018; Faisal, Muhammad/AAM-6214-2020
OI Erovic, Boban/0000-0001-5706-1056; Faisal, Muhammad/0000-0001-6564-0410;
   Janik, Stefan/0000-0002-1161-4871
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NR 43
TC 12
Z9 14
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD MAY
PY 2021
VL 13
IS 10
AR 2482
DI 10.3390/cancers13102482
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA SI2SZ
UT WOS:000654677600001
PM 34069610
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Thomas, M
   Makey, IA
   Buchanan, MA
   Heckman, MG
   White, LJ
   Lechtenberg, BJ
   Wigle, D
   Shen, KR
   Blackmon, SH
AF Thomas, Mathew
   Makey, Ian A.
   Buchanan, Mauricia A.
   Heckman, Michael G.
   White, Launia J.
   Lechtenberg, Bettie J.
   Wigle, Dennis
   Shen, K. Robert
   Blackmon, Shanda H.
TI A Comparison of Negative Pressure and Conventional Therapy in Infected
   Open Chest Wounds
SO SURGICAL INFECTIONS
LA English
DT Article
DE bronchopleural fistula; chronic wound; empyema; negative pressure
   therapy; wound care
ID VACUUM-ASSISTED CLOSURE; ONSET ATRIAL-FIBRILLATION; OPEN WINDOW
   THORACOSTOMY; POSTPNEUMONECTOMY EMPYEMA; INTRATHORACIC APPLICATION;
   ACCELERATED TREATMENT; MANAGEMENT; RESECTION; DEVICE
AB Background: The role of negative pressure wound therapy (NPWT) in the management of open chest wounds is unclear. Our aim was to determine the safety and efficacy of NPWT compared with conventional therapy for open chest wounds.
   Methods: Ten patients with infected open chest wounds were included in a prospective trial of NPWT after surgical debridement. Their outcomes were compared with those of 11 control patients treated during the same period with surgical debridement and open chest packing only. The control group data were obtained by retrospective review of medical records.
   Results: The median duration of NPWT was eight days (range 2-29 days), with closure in eight patients (80%). Two patients having NPWT had unveiling of occult pleural fistulas leading to early discontinuation. The patients having NPWT had a shorter median time to closure (7 versus 18 days; p = 0.071) and shorter initial (median 6 versus 20 days; p = 0.026) and total (median 6 versus 25 days; p = 0.024) hospital length of stay. Control patients had higher rates of new-onset atrial fibrillation (46% versus 0; p = 0.035) and septic shock (64% versus 10%; p = 0.024). The chest was either closed or healing at the time of the last visit in 100% of the NPWT patients versus 73% of control patients (p = 0.28). The 1-year survival estimates were 90% for the NPWT patients and 80% for the control patients (p = 0.69).
   Conclusion: Negative pressure wound therapy is feasible and safe for open infected chest wounds in selected patients compared with open packing alone and may reduce hospital stay duration and major complication rates.
C1 [Thomas, Mathew; Makey, Ian A.; Buchanan, Mauricia A.] Mayo Clin, Dept Cardiothorac Surg, Jacksonville, FL 32224 USA.
   [Heckman, Michael G.; White, Launia J.] Mayo Clin, Dept Biomed Stat & Informat, Jacksonville, FL 32224 USA.
   [Lechtenberg, Bettie J.; Wigle, Dennis; Shen, K. Robert; Blackmon, Shanda H.] Mayo Clin, Div Thorac Surg, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Thomas, M (通讯作者)，Mayo Clin, Dept Cardiothorac Surg, Jacksonville, FL 32224 USA.
EM Thomas.mathew@mayo.edu
OI Thomas, Mathew/0000-0003-4609-0833
FU Thoracic Surgery Foundation through Acelity, Inc.
FX This project was funded by a peer-reviewed grant from the Thoracic
   Surgery Foundation through Acelity, Inc.
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NR 25
TC 2
Z9 2
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD NOV 1
PY 2021
VL 22
IS 9
BP 955
EP 961
DI 10.1089/sur.2020.397
EA MAY 2021
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA XB7KP
UT WOS:000655228200001
PM 34042543
DA 2026-07-24
ER
PT J
AU De Rooij, L
   van Kuijk, SMJ
   van Haaren, ERM
   Janssen, A
   Vissers, YLJ
   Beets, GL
   van Bastelaar, J
AF De Rooij, L.
   van Kuijk, S. M. J.
   van Haaren, E. R. M.
   Janssen, A.
   Vissers, Y. L. J.
   Beets, G. L.
   van Bastelaar, J.
TI Negative pressure wound therapy does not decrease postoperative wound
   complications in patients undergoing mastectomy and flap fixation
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SEROMA FORMATION; TISSUE GLUE; METAANALYSIS; INFECTIONS; PREVENTION;
   SUTURES
AB Patients and breast cancer surgeons are frequently confronted with wound complications after mastectomy. Negative pressure wound therapy (NPWT) is a promising technique for preventing wound complications after skin closure in elective surgery. However, a clinical study evaluating postoperative complications following the use of NPWT, focusing solely on closed incisions in patients undergoing mastectomy, has yet to be performed. Between June 2019 and February 2020, 50 consecutive patients underwent mastectomy with NPWT during the first seven postoperative days. This group was compared to a cohort of patients taking part in a randomized controlled trial between June 2014 and July 2018. Primary outcome was the rate of postoperative wound complications, i.e. surgical site infections, wound necrosis or wound dehiscence during the first three postoperative months. Secondary outcomes were the number of patients requiring unplanned visits to the hospital and developing clinically significant seroma (CSS). In total, 161 patients were analyzed, of whom 111 patients in the control group (CON) and 50 patients in the NPWT group (NPWT). Twenty-eight percent of the patients in the NPWT group developed postoperative wound complications, compared to 18.9% in the control group (OR=1.67 (95% CI 0.77-3.63), p=0.199). The number of patients requiring unplanned visits or developing CSS was not statistically significant between the groups. This study suggests that Avelle negative pressure wound therapy in mastectomy wounds does not lead to fewer postoperative wound complications. Additionally, it does not lead to fewer patients requiring unplanned visits or fewer patients developing clinically significant seromas.Trial registration: ClinicalTrials.gov number, NCT03942575. Date of registration: 08/05/2019.
C1 [De Rooij, L.; van Haaren, E. R. M.; Janssen, A.; Vissers, Y. L. J.; van Bastelaar, J.] Zuyderland Med Ctr, Dept Surg, Postbus 5500, NL-6130 MB Sittard, Netherlands.
   [van Kuijk, S. M. J.] Maastricht Univ, Med Ctr, Dept Clin Epidemiol & Med Technol Assessment, Maastricht, Netherlands.
   [Beets, G. L.] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Surg, Amsterdam, Netherlands.
   [Beets, G. L.] Univ Maastricht, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands.
C3 Maastricht University; Netherlands Cancer Institute; Maastricht
   University
RP De Rooij, L (通讯作者)，Zuyderland Med Ctr, Dept Surg, Postbus 5500, NL-6130 MB Sittard, Netherlands.
EM l.derooij@zuyderland.nl
RI Beets, Geerard/G-2682-2013; van Kuijk, Sander/AAH-3239-2021
CR [Anonymous], 2016, Global Guidelines for the Prevention of Surgical Site Infection
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NR 22
TC 19
Z9 21
U1 1
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 5
PY 2021
VL 11
IS 1
AR 9620
DI 10.1038/s41598-021-89036-3
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SK8IG
UT WOS:000656459200001
PM 33953312
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ou, KL
   Tzeng, YS
   Liu, HH
   Wu, CJ
   Chen, CY
   Chou, YY
   Hsu, KF
   Wang, CH
   Dai, NT
   Chang, CK
AF Ou, Kuang-Ling
   Tzeng, Yuan-Sheng
   Liu, Hung-Hui
   Wu, Chien-Ju
   Chen, Chun-Yu
   Chou, Yu-Yu
   Hsu, Kuo-Feng
   Wang, Chih-Hsin
   Dai, Niann-Tzyy
   Chang, Chun-Kai
TI Negative Pressure Wound Therapy in Conjunction With Artificial Dermis
   for Burned Hand Reconstruction
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; burns; hand; artificial dermis
ID SUBSTITUTION; CONTRACTURE; INTEGRA
AB Introduction
   Proper wound care along with the use of skin grafts over deep burn wounds has been the standard treatment. However, the goal in burn wound care has shifted from achieving a satisfactory survival rate to improving long-term form and function of the healed wound, which is sometimes hindered by scar contracture. This has prompted surgeons to find alternative ways to treat burn wounds without compromising function. Among burn cases, hand injuries are the most problematic when it comes to delicate function recovery. Methods
   This study presents the results of conjunctive use of a bilayer artificial dermis, negative pressure wound therapy, and split-thickness skin grafts for grafting over acute burn wounds and scar-releasing defects after severe hand burns. Results
   Three months after the operation, the scar was soft and pliable, the aesthetic outcome was good, and the patients gained much improvement in hand function and quality oflife. Conclusions
   The combined technique achieved a good scar quality and aesthetic effect on burned hands as well as excellent functional outcome, which resulted in major improvements and an independent life for the patient.
C1 [Ou, Kuang-Ling] Univ Southern Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90007 USA.
   [Ou, Kuang-Ling] Univ Southern Calif, Ostrow Sch Dent, Los Angeles, CA 90007 USA.
   [Ou, Kuang-Ling; Tzeng, Yuan-Sheng; Liu, Hung-Hui; Wu, Chien-Ju; Chen, Chun-Yu; Chou, Yu-Yu; Hsu, Kuo-Feng; Wang, Chih-Hsin; Dai, Niann-Tzyy; Chang, Chun-Kai] Natl Def Med Ctr, Triserv Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, Taipei, Taiwan.
   [Chou, Yu-Yu; Chang, Chun-Kai] Kaohsiung Armed Forces Gen Hosp, Dept Surg, Zuoying Branch, 553 Junxiao Rd, Kaohsiung 813, Taiwan.
C3 University of Southern California; University of Southern California;
   National Defense Medical University; Tri-Service General Hospital
RP Chang, CK (通讯作者)，Kaohsiung Armed Forces Gen Hosp, Dept Surg, Zuoying Branch, 553 Junxiao Rd, Kaohsiung 813, Taiwan.
EM psdrkai@gmail.com
RI Tzeng, Yuan-sheng/AAD-8843-2020
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NR 16
TC 5
Z9 9
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2021
VL 86
IS 2S
SU 1
BP S13
EP S17
DI 10.1097/SAP.0000000000002676
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SK9MG
UT WOS:000656542200003
PM 33438950
DA 2026-07-24
ER
PT J
AU Leitao, MM Jr
   Zhou, QC
   Schiavone, MB
   Cowan, RA
   Smith, ES
   Iasonos, A
   Veith, M
   Rafizadeh, M
   Curran, K
   Ramesh, B
   Chi, DS
   Sonoda, Y
   Brown, AK
   Cosin, JA
   Abu-Rustum, NR
   Martino, MA
   Mueller, JJ
   Roche, KL
   Jewell, EL
   Broach, V
   Lambrou, NC
   Diaz, JP
   Zivanovic, O
AF Leitao, Mario M., Jr.
   Zhou, Qin C.
   Schiavone, Maria B.
   Cowan, Renee A.
   Smith, Evan S.
   Iasonos, Alexia
   Veith, Mitchell
   Rafizadeh, Michael
   Curran, Katherine
   Ramesh, Bhavani
   Chi, Dennis S.
   Sonoda, Yukio
   Brown, Amy K.
   Cosin, Jonathan A.
   Abu-Rustum, Nadeem R.
   Martino, Martin A.
   Mueller, Jennifer J.
   Roche, Kara Long
   Jewell, Elizabeth L.
   Broach, Vance
   Lambrou, Nicholas C.
   Diaz, John P.
   Zivanovic, Oliver
TI Prophylactic Negative Pressure Wound Therapy After Laparotomy for
   Gynecologic Surgery A Randomized Controlled Trial
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article; Proceedings Paper
CT 51st Virtual Annual Meeting of the Society-of-Gynecologic-Oncology on
   Women's Cancer
CY MAR 27-31, 2020
CL ELECTR NETWORK
SP Soc Gynecol Oncol
ID SURGICAL-SITE INFECTION; OBESE WOMEN; CANCER; IMPACT; COSTS; PREDICTORS
AB OBJECTIVE: To estimate the effectiveness of prophylactic negative pressure wound therapy in patients undergoing laparotomy for gynecologic surgery.
   METHODS: We conducted a randomized controlled trial. Eligible, consenting patients, regardless of body mass index (BMI), who were undergoing laparotomy for presumed gynecologic malignancy were randomly allocated to standard gauze or negative pressure wound therapy. Patients with BMIs of 40 or greater and benign disease also were eligible. Randomization, stratified by BMI, occurred after skin closure. The primary outcome was wound complication within 30 (+/- 5) days of surgery. A sample size of 343 per group (N=686) was planned.
   RESULTS: From March 1, 2016, to August 20, 2019, we identified 663 potential patients; 289 were randomized to negative pressure wound therapy (254 evaluable participants) and 294 to standard gauze (251 evaluable participants), for a total of 505 evaluable patients. The median age of the entire cohort was 61 years (range 20-87). Four hundred ninety-five patients (98%) underwent laparotomy for malignancy. The trial was eventually stopped for futility after an interim analysis of 444 patients. The rate of wound complications was 17.3% in the negative pressure wound therapy (NPWT) group and 16.3% in the gauze group, absolute risk difference 1% (90% CI -4.5 to 6.5%; P =.77). Adjusted odds ratio controlling for estimated blood loss and diabetes was 0.99 (90% CI 0.621.60). Skin blistering occurred in 33 patients (13%) in the NPWT group and in three patients (1.2%) in the gauze group (P<.001).
   CONCLUSION: Negative pressure wound therapy after laparotomy for gynecologic surgery did not lower the wound complication rate but did increase skin blistering.
C1 Mem Sloan Kettering Canc Ctr, Dept Biostat & Epidemiol, Weill Cornell Med Coll,Dept Surg,Gynecol Serv, Dept Obstet & Gynecol,Mem Sloan Kettering Canc Ct, 1275 York Ave, New York, NY 10021 USA.
   Hartford Healthcare Canc Inst, Div Gynecol Oncol, Hartford, CT USA.
   Lehigh Valley Canc Inst, Allentown, PA USA.
   Miami Canc Inst, Miami, FL USA.
C3 Memorial Sloan Kettering Cancer Center; Cornell University; Weill
   Cornell Medicine
RP Leitao, MM Jr (通讯作者)，Mem Sloan Kettering Canc Ctr, Dept Surg, Gynecol Serv, New York, NY 10021 USA.
EM leitaom@mskcc.org
RI Zivanovic, Oliver/AAK-9955-2021; zhou, qin/ISV-5657-2023
FU Stryker/Novadaq; Olympus; GRAIL; Merck; AstraZeneca; National Cancer
   Institute [P30CA008748] Funding Source: NIH RePORTER
FX Dr. Leitao reports personal fees from Intuitive Surgical, Inc. and
   JNJ/Ethicon; Dr. Jewell reports personal fees from Covidien/Medtronic;
   Dr. Chi reports personal fees from Bovie Medical Co., Verthermia Inc.
   (now Apyx Medical Corp.), C Surgeries, and Biom `Up, as well as previous
   stock ownership in Intuitive Surgical, Inc. and TransEnterix, Inc. Dr.
   Abu-Rustum reports grants from Stryker/Novadaq, Olympus, and GRAIL. Dr.
   Iasonos reports personal fees from Mylan. Dr. Martino is a patient
   safety consultant for Intuitive, Surgical, Inc., JNJ, Medtronic, and
   CMR, as well as an education speaker for GlaxoSmithKline and a peer
   reviewer for UpToDate. Dr. Lambrou is a consultant for Ethicon and
   Intuitive Surgical, Inc. Dr. Diaz is a speaker and has research grant
   support from Merck and AstraZeneca, and he is a consultant for ConMed.
   Dr. Cosin is a consultant for Medtronic. The other authors did not
   report any potential conflicts of interest.
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NR 21
TC 18
Z9 24
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD FEB
PY 2021
VL 137
IS 2
BP 334
EP 341
DI 10.1097/AOG.0000000000004243
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Obstetrics & Gynecology
GA SL0UE
UT WOS:000656630800023
PM 33416292
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Nuutila, K
   Eriksson, E
AF Nuutila, Kristo
   Eriksson, Elof
TI Moist Wound Healing with Commonly Available Dressings
SO ADVANCES IN WOUND CARE
LA English
DT Review
DE absorptive capacity; antimicrobials; moist wound dressings; moist wound
   healing; negative pressure wound therapy; wear time; water vapor
   transmission rate
ID VAPOR TRANSMISSION RATE; FOAM DRESSINGS; SKIN WOUNDS; INFLAMMATION; WET;
   SILVER; HONEY; MICROENVIRONMENT; INFECTION; THERAPY
AB Significance: A moist wound environment has several benefits that result in faster and better quality of healing. It facilitates autolytic debridement, reduces pain, reduces scarring, activates collagen synthesis, facilitates and promotes keratinocyte migration over the wound surface, and supports the presence and function of nutrients, growth factors, and other soluble mediators in the wound microenvironment.
   Recent Advances: Wound dressings can be utilized to create, maintain, and control a moist environment for healing. Moist wound dressings can be divided into films, foams, hydrocolloids, hydrogels, and alginates. We are also including negative pressure wound therapy systems in the moist dressings.
   Critical Issues: An optimal wound dressing should provide a moist environment and have an optimal water vapor transmission rate (WVTR) and absorptive capacity. It should also protect the wound against trauma and contamination and be easy to apply, painless to remove, and esthetically acceptable or even pleasing.
   Future Directions: Interventions, particularly dressing changes, by medical caregivers are labor intensive and expensive and there should be a continuous effort to reduce their number per week. Smart dressings with integrated microsensors and delivery capabilities that would allow wireless real-time monitoring and treatment of the wound would be very advantageous. This way the state of the wound as well as the wear time of the dressing could be assessed without dressing removal or visit to the wound care center. In addition, an ability to adjust the WVTRs to the exudate level of the wound (or having a large absorptive capacity without changing the WVTR) would be useful. This feature would guarantee an optimal level of hydration of the wound surface throughout the treatment.
C1 [Nuutila, Kristo] Harvard Med Sch, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   [Eriksson, Elof] Harvard Med Sch, Dept Surg, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   Medical School
RP Nuutila, K (通讯作者)，Harvard Med Sch, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM kristo.nuutila@gmail.com
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NR 92
TC 516
Z9 570
U1 19
U2 282
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD DEC 1
PY 2021
VL 10
IS 12
BP 685
EP 698
DI 10.1089/wound.2020.1232
EA FEB 2021
PG 14
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA US6EF
UT WOS:000656636200001
PM 32870777
OA Green Submitted, hybrid
HC Y
HP N
DA 2026-07-24
ER
PT J
AU Takami, Y
   Tanida, S
   Hoshino, N
   Sakurai, Y
   Amano, K
   Akita, K
   Hayashi, R
   Maekawa, A
   Izawa, H
   Takagi, Y
AF Takami, Yoshiyuki
   Tanida, Shin-ichi
   Hoshino, Naoki
   Sakurai, Yusuke
   Amano, Kentaro
   Akita, Kiyotoshi
   Hayashi, Ryosuke
   Maekawa, Atsuo
   Izawa, Hideo
   Takagi, Yasushi
TI Prophylactic use of vacuum-assisted closure system for cannula sites: A
   case of extracorporeal biventricular assist devices for 295 days
SO INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Extracorporeal biventricular assist devices; cannula site; negative
   pressure wound therapy; vacuum-assisted closure system
ID MANAGEMENT; INFECTION; SUPPORT
AB We report wound management using a vacuum-assisted closure (VAC) system for the cannula sites of extracorporeal biventricular assist devices (BiVADs) for 295 days in a 23-year old Chinese female patient with fulminant giant cell myocarditis, who finally underwent heart transplantation. When the cannula sites appeared necrotic 3 months after BiVADs placement, she received negative pressure wound therapy prophylactically for four cannula sites, using a VAC system for 3 months, followed by no infections. Such prophylactic VAC therapy, using the skin barrier paste usually used for the ostomy pouching system to create a flatter surface and airtightness, may be useful to avoid cannula site infections, which is still a fatal complication causing sepsis, especially in patients with extracorporeal BiVADs.
C1 [Takami, Yoshiyuki; Tanida, Shin-ichi; Sakurai, Yusuke; Amano, Kentaro; Akita, Kiyotoshi; Hayashi, Ryosuke; Maekawa, Atsuo; Takagi, Yasushi] Fujita Hlth Univ, Sch Med, Dept Cardiovasc Surg, 1-98 Dengakugakubo Kutsukake Cho, Toyoake, Aichi 4701192, Japan.
   [Hoshino, Naoki; Izawa, Hideo] Fujita Hlth Univ, Sch Med, Dept Cardiol, Toyoake, Aichi, Japan.
C3 Fujita Health University; Fujita Health University
RP Takami, Y (通讯作者)，Fujita Hlth Univ, Sch Med, Dept Cardiovasc Surg, 1-98 Dengakugakubo Kutsukake Cho, Toyoake, Aichi 4701192, Japan.
EM mytakami@fujita-hu.ac.jp
OI Takami, Yoshiyuki/0000-0002-4623-6233; Hayashi,
   Ryosuke/0000-0003-2334-1003
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NR 8
TC 3
Z9 3
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0391-3988
EI 1724-6040
J9 INT J ARTIF ORGANS
JI Int. J. Artif. Organs
PD FEB
PY 2022
VL 45
IS 2
BP 227
EP 230
AR 0391398821991156
DI 10.1177/0391398821991156
EA FEB 2021
PG 4
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA YK2TI
UT WOS:000657093300001
PM 33530821
DA 2026-07-24
ER
PT J
AU Roberts, DJ
   Murphy, C
   Strauss, SA
   Brandys, T
   Corrales-Medina, V
   Zhang, J
   Lalonde, KA
   Meulenkamp, B
   Jennings, A
   Forster, AJ
   McIsaac, DI
   Nagpal, SK
AF Roberts, Derek J.
   Murphy, Christine
   Strauss, Shira A.
   Brandys, Timothy
   Corrales-Medina, Vicente
   Zhang, Jing
   Lalonde, Karl-Andre
   Meulenkamp, Bradley
   Jennings, Alison
   Forster, Alan J.
   McIsaac, Daniel I.
   Nagpal, Sudhir K.
TI Structure, processes, and initial outcomes of The Ottawa Hospital
   Multi-Specialist Limb-Preservation Clinic and Programme: A
   unique-in-Canada quality improvement initiative
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE arterial ulcer; diabetic foot ulcer; limb-preservation clinic;
   postsurgical wound; venous ulcer; wounds and injuries
ID WOUND CARE CENTER; DIABETIC FOOT; MAJOR AMPUTATIONS; OF-LIFE; TEAM;
   MANAGEMENT; REVASCULARIZATION; EPIDEMIOLOGY; GUIDELINES; EXPERIENCE
AB In 2017, The Ottawa Hospital initiated a unique-in-Canada quality improvement initiative by opening a novel, multi-specialist limb-preservation clinic. We sought to describe the structure, processes, and initial outcomes of the clinic and evaluate whether it is achieving its mandate of providing high-quality wound clinical care, education, and research. We conducted a descriptive prospective cohort study alongside a nested study of 162 clinic patients requiring serial assessments. There have been 1623 visits, mostly (72.2%) from outpatients. During 17.8% of visits, patients were evaluated by >1 specialist. Therapies provided most often included negative-pressure wound therapy (32.7%), biological wound dressings (21.6%), and total contact casting (18.5%). Furthermore, 1.2% underwent toe/ray amputations or skin grafting in clinic and 22.8% were initiated on antimicrobials. Mixed-effects models suggested that mean wound volumes for those requiring serial assessments decreased by 1.6 (95% confidence interval = -0.86 to -2.27) cm(3) between visits. The clinic provided seven rotations to vascular surgery, infectious diseases, dermatology, and palliative care physicians; three nursing preceptorships; and two educational workshops. It also initiated provincial and national vascular health and wound care research initiatives. This study may be used to guide development of other limb-preservation clinics and programmes. Findings support that our programme is achieving its mandate.
C1 [Roberts, Derek J.; Murphy, Christine; Strauss, Shira A.; Brandys, Timothy; Nagpal, Sudhir K.] Univ Ottawa, Dept Surg, Div Vasc & Endovasc Surg, Ottawa Hosp Civ Campus,Room A280,1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada.
   [Roberts, Derek J.; Jennings, Alison; Forster, Alan J.; McIsaac, Daniel I.] Ottawa Hosp Res Inst, Ottawa, ON, Canada.
   [Corrales-Medina, Vicente] Univ Ottawa, Dept Med, Div Infect Dis, Ottawa, ON, Canada.
   [Zhang, Jing] Univ Ottawa, Dept Surg, Div Plast & Reconstruct Surg, Ottawa, ON, Canada.
   [Lalonde, Karl-Andre; Meulenkamp, Bradley] Univ Ottawa, Dept Surg, Div Orthopaed Surg, Ottawa, ON, Canada.
   [Forster, Alan J.; McIsaac, Daniel I.] IC ES, Toronto, ON, Canada.
   [Forster, Alan J.] Univ Ottawa, Dept Med, Ottawa, ON, Canada.
   [Forster, Alan J.; McIsaac, Daniel I.] Ottawa Hosp, Ottawa, ON, Canada.
   [Forster, Alan J.; McIsaac, Daniel I.] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
   [McIsaac, Daniel I.] Univ Ottawa, Dept Anesthesiol, Ottawa, ON, Canada.
   [McIsaac, Daniel I.] Univ Ottawa, Dept Pain Med, Ottawa, ON, Canada.
C3 University of Ottawa; Ottawa Hospital Research Institute; University of
   Ottawa; Ottawa Hospital Research Institute; University of Ottawa;
   University of Ottawa; University of Ottawa; University of Ottawa;
   University of Ottawa; Ottawa Hospital Research Institute; University of
   Ottawa; University of Ottawa; University of Ottawa
RP Roberts, DJ (通讯作者)，Univ Ottawa, Dept Surg, Div Vasc & Endovasc Surg, Ottawa Hosp Civ Campus,Room A280,1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada.; Roberts, DJ (通讯作者)，Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa Hosp Civ Campus,Room A280,1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada.
EM derek.roberts01@gmail.com
RI Strauss, Shira/AAS-6859-2020; Roberts, Derek/L-6229-2019
OI Jennings, Alison/0000-0002-9452-3990; Corrales-Medina,
   Vicente/0000-0002-9691-491X
FU Department of Surgery, University of Ottawa (Ottawa, Ontario, Canada)
FX We thank Nadia Khan, MD, for assisting with taking photos of the clinic.
   This study was supported by funding from the Department of Surgery,
   University of Ottawa (Ottawa, Ontario, Canada).
CR Aksoy DY, 2004, EXP CLIN ENDOCR DIAB, V112, P526, DOI 10.1055/s-2004-821310
   [Anonymous], 2008, DICT EPIDEMIOLOGY, V5th
   Rubio JA, 2014, INT J LOW EXTR WOUND, V13, P22, DOI 10.1177/1534734614521234
   Bakker K, 2012, DIABETES-METAB RES, V28, P116, DOI 10.1002/dmrr.2254
   Benchimol EI, 2015, PLOS MED, V12, DOI 10.1371/journal.pmed.1001885
   Bosma J, 2013, ANN VASC SURG, V27, P1105, DOI 10.1016/j.avsg.2013.01.010
   Brennan MB, 2017, OPEN FORUM INFECT DI, V4, DOI 10.1093/ofid/ofx015
   Chi YW, 2015, VASC MED, V20, P168, DOI 10.1177/1358863X14568677
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   DONABEDIAN A, 1966, MILBANK FUND Q, V44, P166, DOI 10.2307/3348969
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   Kim PJ, 2013, J VASC SURG, V57, P1703, DOI 10.1016/j.jvs.2012.11.112
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   Musuuza J, 2020, J VASC SURG, V71, P1433, DOI 10.1016/j.jvs.2019.08.244
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   Neville RF, 2017, BLOOD PURIFICAT, V43, P218, DOI 10.1159/000452746
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   Ontario CorHealth, 2021, VASCULAR VOLUMES OUT
   Peters CML, 2019, J VASC SURG, V70, P530, DOI 10.1016/j.jvs.2018.11.042
   Rockley M, 2020, J VASC SURG, V72, P250, DOI 10.1016/j.jvs.2019.09.054
   Sholar AD, 2007, ANN PLAS SURG, V58, P279, DOI 10.1097/01.sap.0000248116.28131.94
   Singer AJ, 2017, NEW ENGL J MED, V377, P1559, DOI 10.1056/NEJMra1615243
   Steunenberg SL, 2016, ANN VASC SURG, V36, P310, DOI 10.1016/j.avsg.2016.05.087
   Sumpio BE, 2010, J VASC SURG, V51, P1504, DOI 10.1016/j.jvs.2010.04.010
   Thompson N, 2013, ADV SKIN WOUND CARE, V26, P360, DOI 10.1097/01.ASW.0000431329.50869.6f
   Vartanian SM, 2015, ANN VASC SURG, V29, DOI 10.1016/j.avsg.2014.10.030
   von Elm E, 2008, J CLIN EPIDEMIOL, V61, P344, DOI [10.1016/j.jclinepi.2007.11.008, 10.1111/j.1468-1293.2008.00605.x, 10.1157/13073893]
   Ward Alex, 2014, J Med Econ, V17, P176, DOI 10.3111/13696998.2014.882843
   Xenos ES, 2014, AM J MANAG CARE, V20, pE432
   Yesil S, 2009, EXP CLIN ENDOCR DIAB, V117, P345, DOI 10.1055/s-0028-1112149
NR 36
TC 6
Z9 7
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2022
VL 19
IS 2
BP 326
EP 338
DI 10.1111/iwj.13633
EA JUN 2021
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA YH4HX
UT WOS:000657516800001
PM 34085390
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Crumley, C
AF Crumley, Carolyn
TI Single-Use Negative Pressure Wound Therapy Devices A Technologic
   Analysis
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Disposable; Negative pressure wound therapy; Safety; Single use;
   Technology; Vacuum-assisted closure; Wound vac
AB PURPOSE: The purpose of this technologic analysis was to evaluate single-use negative pressure wound therapy (sNPWT) devices.
   APPROACH: Published literature regarding negative pressure wound therapy, particularly focusing on single-use or disposal devices, was reviewed. Varied features of devices currently available in the United States were drawn from use instructions published by individual manufacturers. Safety information regarding sNPWT was derived from the Manufacturer and User Facility Device Experience (MAUDE) Database.
   CONCLUSIONS: Single-use or disposable negative pressure wound therapy devices provide a safe and effective alternative to traditional negative pressure wound therapy. These devices promote healing of select open wounds and reduce complication rates in closed surgical incisions, when used in accordance with manufacturer guidelines. They may be used in any setting, but they are designed for use in home care and may be applied as a primary treatment option or following a course of traditional negative pressure wound therapy.
C1 [Crumley, Carolyn] St Lukes East Hosp, 3712 NE Beechwood Dr, Lees Summit, MO 64064 USA.
   [Crumley, Carolyn] Univ Missouri, Sinclair Sch Nursing, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia
RP Crumley, C (通讯作者)，St Lukes East Hosp, 3712 NE Beechwood Dr, Lees Summit, MO 64064 USA.
EM carolyn_crumley@sbcglobal.net
CR Bohn G, 2013, J WOUND OSTOMY CONT, V40, P315, DOI 10.1097/WON.0b013e31828f478e
   Dwivedi MK, 2017, J WOUND OSTOMY CONT, V44, P343, DOI 10.1097/WON.0000000000000333
   Hartnett J M, 1998, J Wound Ostomy Continence Nurs, V25, P281, DOI 10.1016/S1071-5754(98)90025-0
   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
   Jeter KF, 1990, CHRONIC WOUND CARE C, P240
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
NR 8
TC 9
Z9 9
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2021
VL 48
IS 3
BP 195
EP 198
DI 10.1097/WON.0000000000000761
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA SM5DV
UT WOS:000657626900002
PM 33951708
DA 2026-07-24
ER
PT J
AU Crumley, C
AF Crumley, Carolyn
TI Negative Pressure Wound Therapy Devices With Instillation/Irrigation
   A Technologic Analysis
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Instillation; Irrigation; Negative pressure wound therapy; Safety;
   Technology; Vacuum-assisted closure; Wound VAC
ID VACUUM-ASSISTED CLOSURE
AB PURPOSE: The purpose of this technologic analysis was to critique technologic features of devices designed to deliver negative pressure wound therapy with instillation or irrigation (iNPWT).
   APPROACH: Published literature regarding negative pressure wound therapy (NPWT) devices with the added feature of instillation or irrigation was reviewed to provide an overview of iNPWT. Varied features of devices currently available in the United States were described based on instructions published by individual manufacturers. Safety information regarding iNPWT was derived from the Manufacturer and User Facility Device Experience (MAUDE) Database.
   CONCLUSIONS: The additional option of instillation or irrigation available with some NPWT devices may provide clinical benefits in carefully selected patients. Advantages may be related to facilitated removal of thick exudate and necrotic tissue. Devices with instillation options are indicated for inpatient settings, with ongoing monitoring of health care professionals. A simpler device with an intermittent irrigation option may be used in the home setting, with proper supervision. More research is needed to demonstrate the clinical effectiveness and cost of the therapy.
C1 [Crumley, Carolyn] St Lukes East Hosp, 3712 NE Beechwood Dr, Lees Summit, MO 64064 USA.
   [Crumley, Carolyn] Univ Missouri, Sinclair Sch Nursing, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia
RP Crumley, C (通讯作者)，St Lukes East Hosp, 3712 NE Beechwood Dr, Lees Summit, MO 64064 USA.
EM carolyn_crumley@sbcglobal.net
CR Alvarez PS, 2018, ANN MED SURG, V36, P246, DOI 10.1016/j.amsu.2018.10.007
   Davis KE, 2016, INT WOUND J, V13, P469, DOI 10.1111/iwj.12456
   Diehm YF, 2020, INT WOUND J, V17, P1740, DOI 10.1111/iwj.13462
   Gabriel A, 2021, PLAST RECONSTR SURG, V147, p68S, DOI 10.1097/PRS.0000000000007614
   Hall KD, 2019, J WOUND OSTOMY CONT, V46, P251, DOI 10.1097/WON.0000000000000516
   Kanapathy M, 2020, INT WOUND J, V17, P1948, DOI 10.1111/iwj.13487
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Lessing M Christian, 2013, Eplasty, V13, pe51
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Plikaitis CM, 2006, EXPERT REV MED DEVIC, V3, P175, DOI 10.1586/17434440.3.2.175
NR 11
TC 4
Z9 4
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2021
VL 48
IS 3
BP 199
EP 202
DI 10.1097/WON.0000000000000760
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA SM5DV
UT WOS:000657626900003
PM 33951709
DA 2026-07-24
ER
PT J
AU Kakagia, DD
   Georgiadis, G
   Drosos, G
AF Kakagia, Despoina D.
   Georgiadis, George
   Drosos, George
TI Dermal Matrices: Game Changers in Leg and Foot Soft Tissue
   Reconstruction? A Case Series
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE dermal matrix; degloving; leg reconstruction; foot reconstruction;
   negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB The present article aims to present the use of dermal matrices in severe degloving, avulsion, and necrotizing injuries of the leg and foot in 3 patients. Conventional reconstruction would require the use of free flaps, since exposure of vessels, nerves, joints, and tendons rendered the mere resurfacing with skin grafts insufficient, and extensive cutaneous detachment precluded the use of local fasciocutaneous flaps. All injuries underwent thorough and repeated surgical debridements and wash outs, followed by negative pressure wound therapy (NPWT). Once negative tissue cultures were obtained, the extremities were resurfaced with dermal matrix and immediately covered by split thickness skin grafts. NPWT on the grafted area for a week effectively secured the grafts on the recipient area. Complete healing was achieved in all grafted areas within 7 to 12 days. The function of joints and tendons as well as the quality of resurfacing at the weight bearing areas were tested and found satisfactory within a follow-up period of 5 to 15 months. The use of combined NPWT and dermal matrices in carefully selected patients provides a reliable and durable reconstructive option for leg and foot injuries with satisfactory functional outcomes.
C1 [Kakagia, Despoina D.; Georgiadis, George; Drosos, George] Democritus Univ Hosp, Alexandroupolis, Greece.
C3 Democritus University of Thrace; Democritus University Thrace Hospital
RP Kakagia, DD (通讯作者)，Democritus Univ Hosp, Dept Surg, Alexandroupolis 68100, Greece.
EM despoinakakagia@yahoo.com
RI Kakagia, Despoina/AAP-1202-2021
OI Kakagia, Despoina/0000-0003-2107-6170
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   Georgakarakos E, 2013, INT J LOW EXTR WOUND, V12, P138, DOI 10.1177/1534734613483769
   Gravvanis A, 2016, J CRANIOFAC SURG, V27, P1711, DOI 10.1097/SCS.0000000000002930
   Gravvanis A, 2011, MICROSURG, V31, P162, DOI 10.1002/micr.20842
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   HIDALGO DA, 1986, CLIN PLAST SURG, V13, P663
   Janssens L, 2015, INT J SURG CASE REP, V7, P61, DOI 10.1016/j.ijscr.2014.11.081
   Alvaro-Afonso FJ, 2020, CURR VASC PHARMACOL, V18, P182, DOI 10.2174/1570161117666190408170144
   Jeng SF, 2003, PLAST RECONSTR SURG, V112, P220, DOI 10.1097/01.PRS.0000066384.90361.5C
   Josty IC, 2001, BRIT J PLAST SURG, V54, P363, DOI 10.1054/bjps.2000.3565
   Kakagia D, 2014, INJURY, V45, P890, DOI 10.1016/j.injury.2012.02.002
   Kakagia D, 2009, Acta Chir Plast, V51, P59
   Kuran I, 2000, PLAST RECONSTR SURG, V105, P574, DOI 10.1097/00006534-200002000-00015
   Melandri D, 2020, INT J LOW EXTR WOUND, V19, P78, DOI 10.1177/1534734619884422
   MCh DKPM, 2018, International Journal Of Medical Science And Clinical Invention, V5, P3383, DOI [10.18535/ijmsci/v5i1.01, 10.18535/ijmsci/v5i1.01, DOI 10.18535/IJMSCI/V5I1.01]
   Ring A, 2016, FRONT SURG, V3, DOI 10.3389/fsurg.2016.00015
   Shamian B, 2016, INT J LOW EXTR WOUND, V15, P82, DOI 10.1177/1534734615604279
   STARK RB, 1959, SURG CLIN N AM, V39, P469
   Struckmann V, 2014, J FOOT ANKLE SURG, V53, P727, DOI 10.1053/j.jfas.2014.06.009
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   Yan HD, 2013, J TRAUMA ACUTE CARE, V74, P604, DOI 10.1097/TA.0b013e31827d5e00
NR 22
TC 3
Z9 3
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2023
VL 22
IS 1
BP 56
EP 62
AR 1534734621990311
DI 10.1177/1534734621990311
EA JUN 2021
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8O4OX
UT WOS:000657903300001
PM 34060922
DA 2026-07-24
ER
PT J
AU Morris, MP
   Christopher, AN
   Patel, V
   Onyekaba, G
   Broach, RB
   Fischer, JP
AF Morris, Martin P.
   Christopher, Adrienne N.
   Patel, Viren
   Onyekaba, Ginikanwa
   Broach, Robyn B.
   Fischer, John P.
TI Negative Pressure Wound Therapy After Abdominal Body Contouring: A
   Comparative Matched Analysis of Outcomes and Cost
SO PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; body contouring; cost; post-operative
   outcomes
ID MASS INDEX; SURGICAL INCISIONS; MANAGEMENT
AB Background:
   Studies that have previously validated the use of incisional negative pressure wound therapy (iNPWT) after body contouring procedures (BCP) have provided limited data regarding associated health care utilization and cost. We matched 2 cohorts of patients after BCP with and without iNPWT and compared utilization of health care resources and post-operative clinical outcomes.
   Methods:
   Adult patients who underwent abdominoplasty and/or panniculectomy between 2015 and 2020 by a single surgeon were identified. Patients were propensity score matched by body mass index (BMI), gender, smoking history, diabetes mellitus, hypertension, and incision type. Primary outcomes included time to final drain removal, outpatient visits, homecare visits, emergency department visits, and cost. Secondary outcomes included surgical site occurrences (SSO), surgical site infections, reoperations, and revisions.
   Results:
   One hundred sixty-six patients were eligible, and 40 were matched (20 with iNPWT and 20 without iNPWT) with a median age of 47 years and BMI of 32 kg/m(2). There were no differences in demographics or intraoperative details (all P > .05). No significant differences were found between the cohorts in terms of health care utilization measures or clinical outcomes (all P > .05). Direct cost was significantly greater in the iNPWT cohort (P = .0498). Inpatient length of stay and procedure time were independently associated with increased cost on multivariate analysis (all P < .0001).
   Conclusion:
   Consensus guidelines recommend the use of iNPWT in high-risk patients, including abdominal BCP. Our results show that iNPWT is associated with equivalent health care utilization and clinical outcomes, with increased cost. Additional randomized controlled trials are needed to further elucidate the cost utility of this technique in this patient population.
C1 [Morris, Martin P.; Christopher, Adrienne N.; Patel, Viren; Onyekaba, Ginikanwa; Broach, Robyn B.; Fischer, John P.] Univ Penn, Dept Surg, Div Plast Surg, Philadelphia, PA 19104 USA.
   [Christopher, Adrienne N.] Thomas Jefferson Univ, Dept Surg, Philadelphia, PA 19107 USA.
C3 University of Pennsylvania; Thomas Jefferson University
RP Morris, MP (通讯作者)，Univ Penn Hlth Syst, Dept Surg, Div Plast Surg, 3400 Civ Ctr Blvd,South Pavilion 14th Floor, Philadelphia, PA 19104 USA.
EM momarti@pennmedicine.upenn.edu
OI Morris, Martin/0000-0002-4552-1411
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
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   ASPS, 2020, STATISTICS-ABINGDON
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   Brisinda, 2020, SURGERY, P30511
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   Desvigne MN, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9341
   Di Cesare M, 2016, LANCET, V387, P1377, DOI 10.1016/S0140-6736(16)30054-X
   Dragu A, 2011, OBES SURG, V21, P1781, DOI 10.1007/s11695-010-0328-3
   Estimate of Bariatric Surgery Numbers, 2021, AM SOC MET BAR SURG
   Galiano RD, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001560
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   Kuper TM, 2020, ANN SURG, V271, P67, DOI 10.1097/SLA.0000000000003435
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   Shiroky J, 2020, SURGERY, V167, P1001, DOI 10.1016/j.surg.2020.01.018
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   Toma T, 2018, OBES SURG, V28, P3333, DOI 10.1007/s11695-018-3323-8
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   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
   Zannis J, 2012, ANN PLAS SURG, V68, P194, DOI 10.1097/SAP.0b013e318212f39a
   Zuelzer HB, 2010, ANN PLAS SURG, V64, P598, DOI 10.1097/SAP.0b013e3181cf9f9e
   Zwanenburg PR, 2020, ANN SURG, V272, P81, DOI 10.1097/SLA.0000000000003644
NR 37
TC 5
Z9 5
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2292-5503
EI 2292-5511
J9 PLAST SURG-CHIR PLAS
JI Plast. Surg.
PD NOV
PY 2022
VL 30
IS 4
BP 360
EP 367
AR 22925503211019627
DI 10.1177/22925503211019627
EA JUN 2021
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5C3YO
UT WOS:000657994500001
PM 36212102
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Shimada, K
   Ojima, Y
   Ida, Y
   Komiya, T
   Matsumura, H
AF Shimada, Kazuki
   Ojima, Yosuke
   Ida, Yukiko
   Komiya, Takako
   Matsumura, Hajime
TI Negative-pressure wound therapy for donor-site closure in radial forearm
   free flap: A systematic review and meta-analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE donor-site closure; dressing; negative-pressure wound therapy; radial
   forearm free flap; skin graft
ID THICKNESS SKIN-GRAFT; MORBIDITY; RECONSTRUCTION; COMPLICATIONS;
   MANAGEMENT; DRESSINGS; DEFECTS; BOLSTER; DEVICE; HEAD
AB Negative-pressure wound therapy (NPWT) is often used for skin graft site dressing, and several studies have reported that its use improves skin graft failure in the forearm flap donor site. The present systematic review aimed to evaluate the efficacy of NPWT with skin graft for donor-site closure in radial forearm free flap (RFFF) reconstruction. A systematic search in PubMed, Web of Science, and Cochrane Library databases was conducted. The search terms used for PubMed were ([radial forearm]) AND ([donor]) AND ([negative pressure or vacuum]). This review was registered in the International Prospective Register of Systematic Reviews and performed in accordance with the preferred reporting items for systematic reviews and meta-analyses statement. Three prospective randomised controlled trials and three retrospective comparative studies were included. Compared with conventional bolster dressing, the use of NPWT dressing did not lead to significant improvements in partial skin graft loss, tendon exposure, and other complications. NPWT improved hand functionality earlier; nonetheless, the cost of the device and dressings was a disadvantage. The use of NPWT for skin graft fixation in the RFFF donor site is not generally recommended.
C1 [Shimada, Kazuki; Ojima, Yosuke; Ida, Yukiko; Komiya, Takako; Matsumura, Hajime] Tokyo Med Univ, Dept Plast & Reconstruct Surg, Tokyo, Japan.
C3 Tokyo Medical University
RP Matsumura, H (通讯作者)，Tokyo Med Univ, Dept Plast & Reconstruct Surg, Shinjyuku Ku, 6-7-1 Nishishinjyuku, Tokyo 1600023, Japan.
EM hmatsu-tki@umin.ac.jp
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   Vig S, 2011, J TISSUE VIABILITY, V20, pS1, DOI 10.1016/j.jtv.2011.07.002
   Webster J, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub3
   Wynn M, 2019, J TISSUE VIABILITY, V28, P152, DOI 10.1016/j.jtv.2019.04.001
   Xia CY, 2014, MOL MED REP, V9, P1749, DOI 10.3892/mmr.2014.1997
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NR 48
TC 20
Z9 23
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2022
VL 19
IS 2
BP 316
EP 325
DI 10.1111/iwj.13632
EA JUN 2021
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA YH4HX
UT WOS:000658534900001
PM 34101358
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wei, DQ
   Xu, YB
   Xiang, FF
   Ye, JW
AF Wei, Daiqing
   Xu, Yangbo
   Xiang, Feifan
   Ye, Junwu
TI Secondary below-knee amputation following open reduction and internal
   fixation of a closed pilon fracture A case report and algorithm for
   management
SO MEDICINE
LA English
DT Article
DE amputation; case report; closed fracture; ischemia; pilon fracture
ID ANKLE FRACTURE
AB Rationale: Despite significant advances in surgical techniques and implants, the clinical outcome of high-energy pilon fractures remains unsatisfactory, which continues to represent numerous challenges for orthopedic trauma surgeons. Patient concerns: A 62-year-old man injured his right ankle after falling from a 3 m high place. There were no open wounds or other complications. Diagnoses: According to the X-ray and CT scans, the patient was diagnosed with pilon fracture (type AO-43-C2) and lateral malleolus fracture of the right limb. Interventions: The patient was initially treated with calcaneal traction upon admission to a primary hospital. Five days after the injury, the patient underwent open reduction and internal fixation (ORIF) of the fracture and vacuum sealing drainage (VSD) for wound closure. Outcomes: The patient presented to our hospital on the 9th day after the first ORIF operation because of critical ischemia of the affected foot and distal lower leg. Blood circulation did not improve after a series of salvage treatments, and below-knee amputation was ultimately performed. Lessons: This is a rare case of complete ischemic necrosis following ORIF surgery of a closed pilon fracture due to iatrogenic damage. Standardized treatment that strictly follows the guidelines, instructions, or expert consensus should be promoted in this kind of complicated pilon fracture.
C1 [Wei, Daiqing; Xu, Yangbo; Xiang, Feifan; Ye, Junwu] Southwest Med Univ, Dept Orthopaed, Affiliated Hosp, 25 Tai Ping St, Luzhou 646000, Sichuan, Peoples R China.
   [Wei, Daiqing; Xu, Yangbo; Xiang, Feifan; Ye, Junwu] Sichuan Prov Lab Orthopaed Engn, Luzhou, Sichuan, Peoples R China.
C3 Southwest Medical University
RP Ye, JW (通讯作者)，Southwest Med Univ, Dept Orthopaed, Affiliated Hosp, 25 Tai Ping St, Luzhou 646000, Sichuan, Peoples R China.
EM 1456865780@qq.com
FU Research Project of the Education Department of Sichuan Province
   [18ZA0533]
FX This work was supported by the Research Project of the Education
   Department of Sichuan Province (grant number: 18ZA0533).
CR Bear J, 2018, CURR REV MUSCULOSKE, V11, P537, DOI 10.1007/s12178-018-9519-7
   Bellezza PA, 2017, J FOOT ANKLE SURG, V56, P92, DOI 10.1053/j.jfas.2016.08.006
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NR 12
TC 2
Z9 2
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 19
PY 2021
VL 100
IS 7
AR e24791
DI 10.1097/MD.0000000000024791
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SO4ZR
UT WOS:000658982900075
PM 33607836
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hsu, KF
   Chiu, YL
   Chiao, HY
   Chen, CY
   Chang, CK
   Wu, CJ
   Peng, YJ
   Wang, CH
   Dai, NT
   Chen, SG
   Tzeng, YS
AF Hsu, Kuo-Feng
   Chiu, Yu-Lung
   Chiao, Hao Yu
   Chen, Chun-Yu
   Chang, Chun-Kai
   Wu, Chien-Ju
   Peng, Yi-Jen
   Wang, Chih-Hsin
   Dai, Niann-Tzyy
   Chen, Shyi-gen
   Tzeng, Yuan-Sheng
TI Negative-pressure wound therapy combined with artificial dermis
   (Terudermis) followed by split-thickness skin graft might be an
   effective treatment option for wounds exposing tendon and bone A
   retrospective observation study
SO MEDICINE
LA English
DT Article
DE artificial dermis; negative-pressure wound therapy; tendon and bone
   exposed wounds; terudermis; vacuum-assisted closure
ID REGENERATION TEMPLATE; RECONSTRUCTIVE SURGERY; TISSUE DEFECTS;
   FREE-FLAP; INTEGRA; REPAIR; SCALP; MODEL; HAND
AB Skin grafts are not suitable for closing tendon- or bone-exposing wounds, which require flap surgery. Dermal regeneration templates have value for closing such wounds, but the disadvantages of the technique include implantation failures because of infection, hematoma formation, or inappropriate immobilization. Negative-pressure wound therapy was reported to increase graft acceptance in difficult wounds. This retrospective case series of 65 patients evaluated negative-pressure therapy combined with artificial dermis for the treatment of acute or chronic tendon- or bone-exposing wounds. The artificial dermis was placed after adequate wound-bed preparation, with simultaneous application of a vacuum-assisted closure system. Split-thickness skin grafting was performed after the implanted artificial dermis had become established. The overall success rate was 88.1% (59/67): 88.6% (39/44) in the chronic wounds group and 87% (20/23) in the acute-trauma group separately. The overall mean survival time of artificial dermis in success cases was 13.24 +/- 7.14 days. In separately, the survival time of artificial dermis had no statistically difference in chronic wound group (13.64 +/- 7.53 vs 12.60 +/- 5.86. P = .943), but had significant statistical difference in acute trauma group (12.45 +/- 6.44 days vs 23.33 +/- 4.04 days, P = .018). Also, comorbidity of PAOD was found a strong risk factor of failure in chronic wound group (100% vs 23.1%, P < 0.001). We concluded that artificial dermis combined with negative-pressure therapy followed by split-thickness skin grafting might be a reliable and effective option for surgical reconstruction of tendon- or bone-exposing wounds, and could decreasing waiting periods of autologous skin graft.
C1 [Hsu, Kuo-Feng; Chiao, Hao Yu; Chen, Chun-Yu; Chang, Chun-Kai; Wu, Chien-Ju; Wang, Chih-Hsin; Dai, Niann-Tzyy; Chen, Shyi-gen; Tzeng, Yuan-Sheng] Triserv Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, Taipei, Taiwan.
   [Peng, Yi-Jen] Triserv Gen Hosp, Dept Pathol, Taipei, Taiwan.
   [Chiu, Yu-Lung] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
C3 Tri-Service General Hospital; Tri-Service General Hospital; National
   Defense Medical University
RP Tzeng, YS (通讯作者)，Dept Plast Surg, 325,Sec 2,Chenggong Rd, Taipei 114, Taiwan.
EM m6246kimo@yahoo.com.tw
RI ; Chiao, Hao Yu/HLX-2170-2023; Peng, Yi-Jen/X-9124-2019; Tzeng,
   Yuan-sheng/AAD-8843-2020
OI Chiao, Hao-Yu/0000-0001-5157-634X; Hsu, Kuo-Feng/0000-0002-6883-1295; 
FU Ministry of Science and Technology [MOST 108-2314-B-016-041];
   Tri-Service General Hospital [TSGH-C107-117]
FX The study was funded by grants MOST 108-2314-B-016-041 from the Ministry
   of Science and Technology and TSGH-C107-117 from Tri-Service General
   Hospital.
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   Wester JL, 2014, OTOLARYNG HEAD NECK, V150, P47, DOI 10.1177/0194599813513713
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NR 28
TC 17
Z9 23
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR 9
PY 2021
VL 100
IS 14
AR e25395
DI 10.1097/MD.0000000000025395
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SO5QO
UT WOS:000659026900076
PM 33832132
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hutchinson, LE
   Franke, JD
   Mailey, BA
AF Hutchinson, Lauren E.
   Franke, Jacob D.
   Mailey, Brian A.
TI Necrotizing fasciitis secondary to lake water inoculation with
   Aeromonas sobria A case report
SO MEDICINE
LA English
DT Article
DE Aeromonas sobria; lake water infection; necrotizing fasciitis
ID MANAGEMENT
AB Rationale: Necrotizing fasciitis (NF) is a rapidly progressing bacterial soft tissue infection with a high mortality rate. It is characterized by significant soft tissue destruction with associated sepsis. The mainstay of treatment is coverage with appropriate broad-spectrum antibiotic therapy and emergent surgical debridement. Patient concerns: A previously healthy 66-year-old female presented with a deep laceration to her right, posterior calf with subsequent contamination with lake water. After the wound was irrigated and closed, the patient developed NF. Diagnosis: Laceration of the right lower extremity complicated by NF secondary to Aeromonas sobria. Interventions: The patient underwent emergent surgical debridements with intravenous broad-spectrum antibiotics and negative pressure wound therapy. The lower extremity was reconstructed with split-thickness skin grafts. Outcomes: The patient's initial penetrating trauma was closed in the emergency room, and the patient was discharged home with antibiotics. She returned the next day with unstable vitals and was admitted to the intensive care unit. Her condition continued to deteriorate, and she underwent serial surgical debridements. Her condition improved and was discharged home after 13 days in the hospital. Lessons Learned: Close monitoring for NF is important for tissue infections sustained in aquatic environments. Timely identification and surgical management of NF increases overall survival.
C1 [Hutchinson, Lauren E.; Mailey, Brian A.] Southern Illinois Univ, Inst Plast Surg, Sch Med, POB 19653, Springfield, IL 62794 USA.
   [Franke, Jacob D.] Southern Illinois Univ, Sch Med, Springfield, IL 62794 USA.
C3 Southern Illinois University System; Southern Illinois University;
   Southern Illinois University System; Southern Illinois University
RP Mailey, BA (通讯作者)，Southern Illinois Univ, Inst Plast Surg, Sch Med, POB 19653, Springfield, IL 62794 USA.
EM bmailey48@siumed.edu
RI ; /AAJ-7965-2021; Franke, Jacob/LSJ-8887-2024
OI Mailey, Brian/0000-0002-2846-7556; 
CR Bhatia N, 2017, CASE REP MED, V2017, DOI 10.1155/2017/4607582
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NR 16
TC 4
Z9 4
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAR 12
PY 2021
VL 100
IS 10
AR e24981
DI 10.1097/MD.0000000000024981
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SO5TN
UT WOS:000659034600062
PM 33725868
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sahin, U
   Demiröz, A
   Sahin, S
   Arslan, H
AF Sahin, Ugur
   Demiroz, Anil
   Sahin, Songul
   Arslan, Hakan
TI Effects of negative pressure wound therapy on an axial congested rabbit
   skin flap model without any bare surface
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Vacum asisted closure; venous skin
   flap; congested flap; axial skin flap; flaps; plastic surgery
ID VACUUM-ASSISTED CLOSURE; VENOUS CONGESTION; SALVAGE; HEPARIN
AB One of the most important problems encountered in reconstructive surgery is partial or total flap loss, and venous congestion is the most common reason. It should be solved as early as possible. The purpose of this study is to investigate the effects of Negative pressure wound therapy (NPWT) on an ideal congested rabbit skin flap model without any open wound. The current study included 28 female, adult, New Zealand albino rabbits. Animals were divided into four groups according to the duration of NPWT to be applied. An axial pattern ideal congested skin flap was designed on the posterior surface of the ear. After surgical intervention on the right ears, we applied NPWT treatment for 2, 4, 6 and 8 days. The left ears were followed without any treatment. Samples were taken for edema, congestion and neo-angiogenesis examination. There was no significant difference between the NPWT applied group and control group in the 2nd, 4th, 6th, and 8th days for edema and neo-angiogenesis and no differences in the 2nd, 6th, and 8th days for congestion. NPWT group had a higher flap survival rate than the control group but without a significant difference. This study used an ideal congested rabbit skin flap model imitating venous congestion. Our findings illustrate that NPWT treatment does not have a significant effect on the congested skin flap model we utilized where a closed system was created maintaining a skin barrier without a bare surface of the flap.
C1 [Sahin, Ugur; Demiroz, Anil; Arslan, Hakan] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Plast Reconstruct & Aesthet Surg Dept, Istanbul, Turkey.
   [Sahin, Songul] Cankiri State Hosp, Pathol Dept, Cankiri, Turkey.
C3 Istanbul University - Cerrahpasa; Cankiri State Hospital
RP Arslan, H (通讯作者)，Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Plast Reconstruct & Aesthet Surg Dept, Istanbul, Turkey.
EM hakanarsln93@gmail.com
RI Demiroz, Anil/C-9553-2019; Arslan, Hakan/A-1770-2017; sahin,
   songul/OJU-6309-2025; Sahin, Ugur/L-4818-2017
OI Demiroz, Anil/0000-0001-6182-6939; Arslan, Hakan/0000-0001-8838-8262; 
FU Istanbul University Scientific Research Projects Committee [52419]
FX This study was financially supported by the Istanbul University
   Scientific Research Projects Committee [Project ID: 52419].
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NR 18
TC 2
Z9 2
U1 0
U2 2
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD APR 1
PY 2022
VL 56
IS 2
BP 115
EP 120
DI 10.1080/2000656X.2021.1934847
EA JUN 2021
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 0K4AX
UT WOS:000659387800001
PM 34106810
OA gold
DA 2026-07-24
ER
PT J
AU Tavares, G
   Tustumi, F
   Tristao, LS
   Bernardo, WM
AF Tavares, Guilherme
   Tustumi, Francisco
   Tristao, Luca Schiliro
   Bernardo, Wanderley Marques
TI Endoscopic vacuum therapy for anastomotic leak in esophagectomy and
   total gastrectomy: a systematic review and meta-analysis
SO DISEASES OF THE ESOPHAGUS
LA English
DT Review
DE negative pressure wound therapy; anastomotic leak; esophagectomy;
   gastrectomy; meta-analysis
ID ASSISTED CLOSURE; WOUND THERAPY; RESECTION; CANCER; PERFORATIONS;
   OUTCOMES; DEFECTS; 3-FIELD
AB The curative treatment for esophageal and gastric cancer is primarily surgical resection. One of the main complications related to esophagogastric surgery is the anastomotic leak. This complication is associated with a prolonged length of stay, reduced quality of life, high treatment costs, and an increased mortality rate. The placement of endoluminal stents is the most frequent endoscopic therapy in these cases. However, since its introduction, endoscopic vacuum therapy has been shown to be a promising alternative in the management of this complication. This study primarily aims to evaluate the efficacy and safety of endoscopic vacuum therapy for the treatment of anastomotic leak in esophagectomy and total gastrectomy. A systematic review and meta-analysis was performed. Studies that evaluated the use of endoscopic vacuum therapy for anastomotic leak in esophagectomy and total gastrectomy were included. Twenty-three articles were included. A total of 559 patients were evaluated. Endoscopic vacuum therapy showed a fistulous orifice closure rate of 81.6% (rate: 0.816; 95% CI: 0.777-0.864) and, when compared to the stent, there is a 16% difference in favor of endoscopic vacuum therapy (risk difference [RD]: 0.16; 95% CI: 0.05-0.27). The risk for mortality in the endoscopic vacuum therapy was 10% lower than in endoluminal stent therapy (RD: -0.10; 95% CI: -0.18 to -0.02). Endoscopic vacuum therapy might have a higher rate of fistulous orifice closure and a lower rate of mortality, compared to intraluminal stenting.
C1 [Tavares, Guilherme; Tustumi, Francisco; Tristao, Luca Schiliro; Bernardo, Wanderley Marques] Ctr Univ Lusiada, Dept Evidence Based Med, Sao Paulo, Brazil.
   [Tustumi, Francisco; Bernardo, Wanderley Marques] Univ Sao Paulo, Dept Evidence Based Med, Sao Paulo, Brazil.
   [Tustumi, Francisco] Hosp Israelita Albert Einstein, Dept Surg, Sao Paulo, Brazil.
C3 Centro Universitario Lusiada; Universidade de Sao Paulo; Hospital
   Israelita Albert Einstein
RP Tavares, G (通讯作者)，St Carolino Rodrigues 17, BR-1055070 Santos, SP, Brazil.
EM tavaresguilherme18@gmail.com
RI Tustumi, Francisco/K-4992-2017; Tavares, Guilherme/AAV-4804-2020;
   Schiliró Tristão, Luca/W-8257-2019
OI Tustumi, Francisco/0000-0001-6695-0496; Orlandini,
   Marina/0000-0002-9157-6536; Tavares, Guilherme/0000-0001-6208-3743;
   Schiliró Tristão, Luca/0000-0002-7197-0915
FU Centro Universitario Lusiada (UNILUS)
FX This research was funded by Centro Universitario Lusiada (UNILUS).
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NR 56
TC 40
Z9 47
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1120-8694
EI 1442-2050
J9 DIS ESOPHAGUS
JI Dis. Esophagus
PD MAY
PY 2021
VL 34
IS 5
AR doaa132
DI 10.1093/dote/doaa132
EA JAN 2021
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA SP1NZ
UT WOS:000659440200006
PM 33479749
DA 2026-07-24
ER
PT J
AU Leuchter, M
   Hitzbleck, M
   Schafmayer, C
   Philipp, M
AF Leuchter, Matthias
   Hitzbleck, Michael
   Schafmayer, Clemens
   Philipp, Mark
TI Use of incisional preventive negative pressure wound therapy in open
   incisional hernia repair: Who benefits?
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE abdominal wall; hernia; iNPWT; matched pair; ROC; surgical site
   infection; wound healing
ID SURGICAL SITE OCCURRENCE; MANAGEMENT; VALIDATION; INFECTION; SCORE
AB Complex surgery of abdominal wall hernia continues to bear the major concern of wound healing disorders. Technical modifications have not been able to sufficiently prevent wound healing impairments or infections, even in clean elective cases, especially when dealing with large-scale hernia defects. Incisional negative pressure wound therapy (iNPWT) in its intentional use as a preventive tool has recently found its way from theoretical and experimental advantages to the clinical routine. Different indications have been defined but evidence is lacking. We performed a retrospective analysis (1/2014-5/2019) of all ventral hernia repairs (n = 386) done in our institution as open sublay mesh reinforcement, partially requiring component separation (CS), receiving iNPWT in selected cases based on single surgeon experience. Pre- and perioperative data included patient and hernia characteristics as well as the employed mesh sizes. Postoperative follow-up (median 38.5 months [interquartile range: 23.4, 53.3]) extended beyond patient dismissal and included the rate of re-admission due to wound healing disorders. The primary outcome was the incidence of surgical site occurrences (SSO). Secondary endpoints included wound-related readmissions, reoperations and recurrences. Patients were matched based on propensity scores in a 1:1 ratio. Propensity scores were calculated based on five preoperative variables, including sex, body-mass-index, American Society of Anesthesiology classification, recurrent hernia repair and operation technique, to identify significant parameters. The rate of SSO was 12% (n = 46) for all operated cases, and the rate of surgical site infection (SSI) was 8.8% (n = 34). In the subgroup of CS (n = 40), the rate increased to 15% (n = 6). The usage of iNPWT (n = 54) led to an in-hospital SSO rate of 14.8% (n = 8) but increased to 33.3% (n = 18) when including the re-admission rate. The SSI rate for the iNPWT cohort was 14.8% (n = 8) with a consecutive need for reoperation (Clavien-Dindo IIIb) in 87.5% (n = 7). In the matched-pair analysis, the hernia-size and mesh-size were the main risk factors for SSO. The use of iNPWT significantly reduced this statistical effect (p = 0.405). In a large and representative patient cohort, we were able to demonstrate that the advantage of iNPWT used after complex abdominal wall repair does not come first hand. Especially in the follow-up, we found a relevant increase in wound healing problems after dismissal. To proof the benefit of iNPWT in these heterogeneous patients, we could identify hernia size and mesh size as individual risk factors that were nihilated by the use of iNPWT. We found it to be favourable to use iNPWT when mesh-size exceeded 450 cm(2).
C1 [Leuchter, Matthias; Hitzbleck, Michael; Schafmayer, Clemens; Philipp, Mark] Univ Med Ctr Rostock, Dept Gen Visceral Vasc & Transplantat Surg, Schillingallee 35, D-18057 Rostock, Germany.
C3 University of Rostock
RP Philipp, M (通讯作者)，Univ Med Ctr Rostock, Dept Gen Visceral Vasc & Transplantat Surg, Schillingallee 35, D-18057 Rostock, Germany.
EM mark.philipp@med.uni-rostock.de
OI Leuchter, Matthias/0000-0003-3178-5579
FU Projekt DEAL
FX Open access funding enabled and organized by Projekt DEAL.
CR Berger RL, 2013, J AM COLL SURGEONS, V217, P974, DOI 10.1016/j.jamcollsurg.2013.08.003
   Condé-Green A, 2013, ANN PLAS SURG, V71, P394, DOI 10.1097/SAP.0b013e31824c9073
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   Liang MK, 2015, SURG INFECT, V16, P36, DOI 10.1089/sur.2014.115
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NR 17
TC 4
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2021
VL 29
IS 5
BP 759
EP 765
DI 10.1111/wrr.12948
EA JUN 2021
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA UK1FO
UT WOS:000659463800001
PM 34110077
OA hybrid
DA 2026-07-24
ER
PT J
AU Higuera-Rueda, CA
   Emara, AK
   Nieves-Malloure, Y
   Klika, AK
   Cooper, HJ
   Cross, MB
   Guild, GN
   Nam, D
   Nett, MP
   Scuderi, GR
   Cushner, FD
   Piuzzi, NS
   Silverman, RP
AF Higuera-Rueda, Carlos A.
   Emara, Ahmed K.
   Nieves-Malloure, Yeni
   Klika, Alison K.
   Cooper, Herbert J.
   Cross, Michael B.
   Guild, George N.
   Nam, Denis
   Nett, Michael P.
   Scuderi, Giles R.
   Cushner, Fred D.
   Piuzzi, Nicolas S.
   Silverman, Ronald P.
TI The Effectiveness of Closed-Incision Negative-Pressure Therapy Versus
   Silver-Impregnated Dressings in Mitigating Surgical Site Complications
   in High-Risk Patients After Revision Knee Arthroplasty: The PROMISES
   Randomized Controlled Trial
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE revision knee arthroplasty; closed incision negative pressure wound
   therapy; surgical site complication; surgical site infection;
   readmission; dressing changes
ID JOINT INFECTION; SAMPLE-SIZE; SURGERY; HIP; DIAGNOSIS; DISEASE; RATES
AB Background: Revision total knee arthroplasty (rTKA) is associated with significant risk of wound-related morbidity. The present study aimed to evaluate the 1) efficacy of closed-incision negative-pressure therapy (ciNPT) vs silver-impregnated antimicrobial dressing (AMD) in mitigating postoperative surgical site complications (SSCs), 2) the effect of ciNPT vs AMD on certain postoperative health utilization parameters, and on 3) patient-reported outcomes (PROs) improvement at 90-day postoperative follow-up.
   Methods: This multicenter randomized controlled trial was conducted between December 2017 and August 2019. Patients >= 22 years, at high risk for SSC, and receiving rTKA with full exchange and reimplantation of new prosthetic components or open reduction and internal fixation of periprosthetic fractures were screened for inclusion. Eligible patients were randomized to receive a commercially available ciNPT system or a silver-impregnated AMD (n = 147, each) for minimum of 5-day duration. Primary outcome was the 90-day incidence of SSCs with stratification in accordance with revision type (aseptic/septic). Secondary outcomes were the 90-day health care utilization parameters (readmission, reoperation, dressing changes, and visits) and PROs.
   Results: Of 294 patients randomized (age: 64.9 +/- 9.0 years, female: 59.6%), 242 (82.0%) patients completed the study (ciNPT: n = 124; AMD: n = 118). The incidence of 90-day SSCs was lower for the ciNPT cohort (ciNPT: 3.4% vs AMD: 14.3%; odds ratio (OR): 0.22, 95% confidence interval (0.08, 0.59); P =.0013). Readmission rates (3.4% vs 10.2%, OR: 0.30(0.11, 0.86); P =.0208) and mean dressing changes (1.1 +/- 0.3 vs 1.3 +/- 1.0; P =.0003) were lower with ciNPT. The differences in reoperation rates, number of visits, and PRO improvement between both arms were not statistically significant (P >.05).
   Conclusion: ciNPT is effective in reducing the 90-day postoperative SSCs, readmission, and number of dressing changes after rTKA. Recommending routine implementation would require true-cost analyses. (C) 2021 The Authors. Published by Elsevier Inc.
C1 [Higuera-Rueda, Carlos A.] Cleveland Clin Florida, Dept Orthopaed Surg, Weston, FL USA.
   [Emara, Ahmed K.; Klika, Alison K.; Piuzzi, Nicolas S.] Cleveland Clin Fdn, Dept Orthopaed Surg, Cleveland, OH USA.
   [Nieves-Malloure, Yeni; Silverman, Ronald P.] KCI Acel, San Antonio, TX USA.
   [Cooper, Herbert J.] Columbia Univ, New York Presbyterian Hosp, Dept Orthopaed Surg, Irving Med Ctr, New York, NY USA.
   [Cross, Michael B.; Cushner, Fred D.] Hosp Special Surg, Dept Orthopaed Surg, New York, NY USA.
   [Guild, George N.] Emory Univ, Dept Orthopaed Surg, Atlanta, GA USA.
   [Nam, Denis] Rush Univ, Med Ctr, Midwest Orthopaed, Chicago, IL USA.
   [Nett, Michael P.] Northwell Hlth Phys Partners Orthopaed Inst Babyl, Babylon, NY USA.
   [Scuderi, Giles R.] Northwell Hlth Phys Partners Orthopaed Inst MEETH, New York, NY USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Columbia
   University; Cornell University; Weill Cornell Medicine;
   NewYork-Presbyterian Hospital; Emory University; Rush University
RP Higuera-Rueda, CA (通讯作者)，Cleveland Clin, Levitetz Dept Orthoped Surg, 2950 Cleveland Clin Blvd, Weston, FL 33331 USA.
RI ; Silverman, Ronald/A-5155-2018; Cooper, H./H-3488-2019; Nett,
   Michael/GXA-3548-2022; Emara, Ahmed/AAC-4309-2019
OI Piuzzi, Nicolas S/0000-0003-3007-7538; 
CR Bedard NA, 2018, J ARTHROPLASTY, V33, pS172, DOI 10.1016/j.arth.2018.03.024
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NR 48
TC 39
Z9 40
U1 0
U2 4
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD JUL
PY 2021
VL 36
IS 7
SU S
BP S295
EP +
DI 10.1016/j.arth.2021.02.076
EA JUN 2021
PG 22
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA SR5HK
UT WOS:000661072200033
PM 33781638
OA hybrid
DA 2026-07-24
ER
PT J
AU Ailaney, N
   Johns, WL
   Golladay, GJ
   Strong, B
   Kalore, N
AF Ailaney, Nikhil
   Johns, William L.
   Golladay, Gregory J.
   Strong, Benjamin
   Kalore, Niraj, V
TI Closed Incision Negative Pressure Wound Therapy for Elective Hip and
   Knee Arthroplasty: A Systematic Review and Meta-Analysis of Randomized
   Controlled Trials
SO JOURNAL OF ARTHROPLASTY
LA English
DT Review
DE closed incision negative pressure wound; therapy; surgical site
   infection; wound complication; total knee arthroplasty; total hip
   arthroplasty
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; COMPLICATIONS;
   DRESSINGS; DRAINAGE; SURGERY; MANAGEMENT; FRACTURES; INFECTION
AB Background: Persistent wound drainage after total joint arthroplasty (TJA) increases the risk of surgical site infections (SSIs). Closed incision negative pressure wound therapy (ciNPWT) decreases infections in traumatic wounds, but evidence for its use after elective TJA is limited. The purpose of this meta-analysis of level I studies is to determine the effect of ciNPWT on risk of SSI and wound complications following TJA.
   Methods: MEDLINE, EMBASE, CINAHL, and Cochrane Library were searched for randomized controlled trials comparing ciNPWT vs standard dressings after total hip (THA) and total knee arthroplasty (TKA). Studies exclusively involving THA for femoral neck fractures were excluded. Risk of SSI and noninfectious wound complications (blisters, seroma, hematoma, persistent drainage, dehiscence, and wound edge necrosis) following TJA were analyzed.
   Results: SSI risk was lower with ciNPWT compared to standard dressings (3.4% vs 7%; relative risk [RR] 0.48, P = .007), specifically in revision THA and TKA (4.1% vs 10.5%; RR 0.41, P = .03). ciNPWT increased the noninfectious complication risk after primary TKA (RR 4.71, P<.0001), especially causing wound blistering (RR 12.66, P<.0001). ciNPWT decreased hospital length of stay by 0.73 days (P = .04) and reoperation rate (RR 0.28, P = .01).
   Conclusion: ciNPWT decreases SSI risk compared to standard dressings after revision TJA, but not primary TJA. ciNPWT is associated with >12-fold increased risk of wound blistering after primary TKA. ciNPWT plays a role in revision TJA management, but additional randomized controlled trials with uniform wound assessment methods must be performed to sufficiently power findings and draw conclusions on the use of ciNPWT after primary TJA. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Ailaney, Nikhil; Johns, William L.] Virginia Commonwealth Univ, Sch Med, Dept Orthopaed Surg, 1200 East Broad St,9th Floor, Richmond, VA 23298 USA.
   [Golladay, Gregory J.; Strong, Benjamin; Kalore, Niraj, V] Virginia Commonwealth Univ Hlth, Dept Orthopaed Surg, Richmond, VA USA.
C3 Virginia Commonwealth University
RP Ailaney, N (通讯作者)，Virginia Commonwealth Univ, Sch Med, Dept Orthopaed Surg, 1200 East Broad St,9th Floor, Richmond, VA 23298 USA.
RI Kalore, Niraj/J-1828-2012; Golladay, Gregory/AAF-5244-2020
OI Kalore, Niraj/0000-0003-3452-418X; Ailaney, Nikhil/0000-0003-2309-6909; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Cooper HJ, 2016, J ARTHROPLASTY, V31, P1047, DOI 10.1016/j.arth.2015.11.010
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   Gillespie BM, 2015, SURG INNOV, V22, P488, DOI 10.1177/1553350615573583
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   Jaberi FM, 2008, CLIN ORTHOP RELAT R, V466, P1368, DOI 10.1007/s11999-008-0214-7
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   Keeney JA, 2019, J ARTHROPLASTY, V34, P723, DOI 10.1016/j.arth.2018.12.008
   Kim JH, 2019, J ARTHROPLASTY, V34, P2804, DOI 10.1016/j.arth.2019.06.020
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   LIBERATI A, 2009, BMJ-BRIT MED J, V6
   Malmsjö M, 2009, ANN PLAS SURG, V63, P676, DOI 10.1097/SAP.0b013e31819ae01b
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   Newman JM, 2019, J ARTHROPLASTY, V34, P554, DOI 10.1016/j.arth.2018.11.017
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NR 43
TC 34
Z9 44
U1 0
U2 6
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD JUL
PY 2021
VL 36
IS 7
BP 2402
EP 2411
DI 10.1016/j.arth.2020.11.039
EA JUN 2021
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA SR5II
UT WOS:000661074600033
PM 33358608
DA 2026-07-24
ER
PT J
AU Kuo, FC
   Hsu, CW
   Tan, TL
   Lin, PY
   Tu, YK
   Chen, PC
AF Kuo, Feng-Chih
   Hsu, Chih-Wei
   Tan, Timothy L.
   Lin, Pao-Yen
   Tu, Yu-Kang
   Chen, Po-Cheng
TI Effectiveness of Different Wound Dressings in the Reduction of Blisters
   and Periprosthetic Joint Infection After Total Joint Arthroplasty: A
   Systematic Review and Network Meta-Analysis
SO JOURNAL OF ARTHROPLASTY
LA English
DT Review
DE wound dressings; total joint arthroplasty; blister; infection; hip; knee
ID TOTAL HIP; KNEE ARTHROPLASTY; CONTROLLED-TRIAL; THERAPY; CONSISTENCY;
   AQUACEL
AB Background: The optimal type of dressing in the setting of total joint arthroplasty (TJA) remains uncertain. The aim of this network meta-analysis was to compare various wound dressings and identify the optimal type of dressings for blister reduction and prevention of periprosthetic joint infection (PJI) in patients after TJA.
   Methods: Studies comparing 2 or more dressing groups after TJA (hip or knee) were systematically searched on PubMed, Embase, and Scopus. Two authors performed the study selection, risk of bias assessment, and data extraction. Both outcomes were assessed using odds ratios (OR) with 95% confidence intervals (CI) and were ranked using surface under the cumulative ranking curve (SUCRA) probabilities to determine a hierarchy of dressings. A sensitivity analysis was performed to reduce the effect of intransitivity between studies.
   Results: A total of 21 studies, consisting of 12 dressing types in 7293 TJAs, were included in the final analysis. The highest incidence of blisters occurred when using negative-pressure wound therapy (OR 9.33, 95% CI 3.51-24.83, vs gauze). All dressings ranked better than gauze in infection rate except for hydrofiber (OR 1.46, 95% CI 0.02-112.53) and fabric dressings (OR 1.46, 95% CI 0.24-9.02). For blister reduction, alginate (SUCRA = 87.7%) and hydrofiber with hydrocolloid (SUCRA = 92.3%) were ranked as the optimal dressings before and after a sensitivity analysis, respectively. Antimicrobial dressing (SUCRA = 83.7%) demonstrated the most efficacy for preventing PJI.
   Conclusion: Based on the evidence from our analysis, an antimicrobial dressing is the optimal dressing to prevent PJI. If negative-pressure wound therapy is used, surgeons should be aware of an increased incidence of blister formation. Further studies should focus on the alginate versus hydrofiber and hydrocolloid dressing to determine the optimal dressing to reduce blisters. (C) 2021 The Author(s). Published by Elsevier Inc.
C1 [Kuo, Feng-Chih] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Orthopaed Surg, Kaohsiung, Taiwan.
   [Hsu, Chih-Wei; Lin, Pao-Yen] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Psychiat, Kaohsiung, Taiwan.
   [Tan, Timothy L.] Thomas Jefferson Univ, Rothman Orthopaed Inst, Philadelphia, PA 19107 USA.
   [Lin, Pao-Yen] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed Sci, Kaohsiung, Taiwan.
   [Tu, Yu-Kang] Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan.
   [Chen, Po-Cheng] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Phys Med & Rehabil, Kaohsiung, Taiwan.
   [Chen, Po-Cheng] Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth, Tainan, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Thomas Jefferson University;
   Rothman Institute; Chang Gung Memorial Hospital; National Taiwan
   University; Chang Gung Memorial Hospital; Chang Gung University;
   National Cheng Kung University
RP Chen, PC (通讯作者)，Kaohsiung Chang Gung Mem Hosp, Dept Phys Med & Rehabil, 123 Dapi Rd, Kaohsiung 833, Taiwan.
RI Tan, Timothy/AAK-4232-2020; Kuo, Feng-Chih/W-3327-2019; Chen,
   Po-Cheng/ABH-6133-2020; Tu, Yu-Kang/C-7303-2009
OI Kuo, Feng-Chih/0000-0001-5205-8333; Chen, Po-Cheng/0000-0002-6386-2850;
   Tu, Yu-Kang/0000-0002-2461-474X
FU Chang Gung Memorial Hospital, Taiwan [CFRPG8H0141]
FX We appreciated the Biostatistics Center of Kaohsiung Chang Gung Memorial
   Hospital for the statistics work. This work was supported by Chang Gung
   Memorial Hospital, Taiwan (grant numbers CFRPG8H0141).
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NR 50
TC 21
Z9 22
U1 1
U2 6
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD JUL
PY 2021
VL 36
IS 7
BP 2612
EP 2629
DI 10.1016/j.arth.2021.02.047
EA JUN 2021
PG 18
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA SR5II
UT WOS:000661074600065
PM 33707123
OA Bronze
DA 2026-07-24
ER
PT J
AU Wei, WL
   Wang, YJ
   Lin, QQ
   Lu, QF
AF Wei, Wenlin
   Wang, Yingjie
   Lin, Qiqing
   Lu, Qifeng
TI Application of nano-silver dressing combined with covered vacuum sealing
   drainage technology in cobra bite
SO MATERIALS EXPRESS
LA English
DT Article
DE Nano-Silver Dressing; VSD Technology; Cobra Bite
ID CHINESE COBRA; DNA; VENOM; NANOPARTICLES; NANOCLUSTERS; FLUORESCENCE
AB Limb swelling, pain, and coagulation dysfunction caused by cobra venom bite are difficult to treat, but the therapeutic effect is not ideal at present. Therefore, it is of great significance to find rapid and effective treatment. To explore the application value of nano-silver dressing combined with covered Vacuum sealing drainage (VSD) technology in Guangxi cobra bite. A total of 90 cases of cobra bite patients treated in our hospital from March to December 2019 were randomly divided into observation group and control group, with 45 cases in each group. The control group was treated with conventional treatment, and the observation group was treated with nanosilver dressing combined with covered VSD technology. The swelling degree of affected limbs, circumference measurement of bilateral limbs, pain degree of affected limbs, inflammatory factors, and coagulation function indexes were compared between the two groups. After treatment, the swelling degree and visual pain scale score of the observation group were lower than those of the control group. The peripheral diameter difference of bilateral limbs in the observation group was smaller than that in the control group 1 d and 3 d after treatment. The levels of inflammatory factors in the observation group were better than those in the control group. The coagulation function of the observation group after treatment was better than that of the control group. Conclusions: This study confirmed for the first time that nano-silver dressing combined with covered VSD technology can effectively eliminate local swelling, relieve pain, eliminate inflammatory reaction, improve blood circulation, and provide a new method for clinical treatment.
C1 [Wei, Wenlin; Wang, Yingjie; Lin, Qiqing; Lu, Qifeng] Youjiang Med Coll Nationalities, Dept Emergency, Affiliated Hosp, Baise 533000, Guangxi, Peoples R China.
C3 Youjiang Medical University for Nationalities
RP Wei, WL (通讯作者)，Youjiang Med Coll Nationalities, Dept Emergency, Affiliated Hosp, Baise 533000, Guangxi, Peoples R China.
FU Affiliated Hospital of Youjiang Medical College for Nationalities
FX This work was supported by the Affiliated Hospital of Youjiang Medical
   College for Nationalities.
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NR 28
TC 1
Z9 1
U1 0
U2 11
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 2158-5849
EI 2158-5857
J9 MATER EXPRESS
JI Mater. Express
PD MAR
PY 2021
VL 11
IS 3
BP 412
EP 418
DI 10.1166/mex.2021.1911
PG 7
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Materials Science
GA SR8AN
UT WOS:000661267700016
DA 2026-07-24
ER
PT J
AU Hill, R
AF Hill, Richard
TI Utilizing Negative Pressure Wound Therapy With Instillation and Dwell
   Time to Achieve Source Control of Complex Polymicrobial Necrotizing
   Aeromonas hydrophila Infection Following a Traumatic Amputation:
   A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell; traumatic
   injury; myonecrosis; Aeromonas hydrophilia; infection
ID RAPID PROGRESSION
AB Introduction. Aquatic propeller injuries can pose significant complications in the care of a patient including gross contamination, delayed onset of ischemia, and exposure to unusual water-associated organisms. This case study highlights a circumstance where source control was achieved in a patient that suffered from a polymicrobial necrotizing Aeromonas hydrophila infection following a traumatic aquatic amputation. Case Report. A 26-year-old female sustained a propeller injury in a lake with brackish water that resulted in multiple significant linear lacerations and avulsions as well as a Gustilo IIIB fracture. Due to the extent of injuries, the limb was deemed unsalvageable. Serial washouts began early in the hospital course, but the patient did not hemodynamically tolerate debridement well. Tissue cultures showed a polymicrobial A hydrophila infection. Achievement of source control was attempted through use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) (instillation of 100 mL of 0.125% Dakin's solution, dwell time of 5 minutes, and 2-hour intervals of NPWTi-d at -125 mm Hg) in conjunction with traditional intravenous antibiotics; when this therapy was initiated, the wound measured 51.0 cm x 38 cm x 4 cm with 6.0 cm undermining along the superior border. Within 2 days of NPWTi-d initiation, lab values normalized, and the patient began to clinically improve. By day 17, the NPWTi-d settings were switched to instillation of 80 mL normal saline with a dwell time of 5 minutes and interval 2 hours of NPWT at -125 mm Hg. At day 25, the wound measured approximately 25.0 cm x 30.0 cm. The NPWTi-d was continued throughout hospitalization until grafting was able to be performed; on hospital day 51, nearly 100% take of split-thickness grafting was noted with no residual tissue loss. At 167 days after the initial injury, the patient took her first steps on the prosthetic limb. Conclusions. Negative pressure wound therapy with instillation and dwell time gives clinicians the option to achieve source control in complex wounds with active, myonecrotic, polymicrobial infections through use of bactericidal solution instillation.
C1 [Hill, Richard] Natchitoches Reg Med Ctr, 501 Keyser Ave, Natchitoches, LA 71457 USA.
RP Hill, R (通讯作者)，Natchitoches Reg Med Ctr, 501 Keyser Ave, Natchitoches, LA 71457 USA.
EM Hill.richardb@gmail.com
RI Hill, Richard/C-5419-2019
CR Bhatia N, 2017, CASE REP MED, V2017, DOI 10.1155/2017/4607582
   Dong J, 2017, J WORLD AQUACULT SOC, V48, P531, DOI 10.1111/jwas.12351
   Fernández-Bravo A, 2019, P NATL ACAD SCI USA, V116, P24084, DOI 10.1073/pnas.1914395116
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   Paolin A, 2016, CELL TISSUE BANK, V17, P611, DOI 10.1007/s10561-016-9589-y
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NR 10
TC 0
Z9 1
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2020
VL 32
SU S
BP 364
EP 368
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SR8KO
UT WOS:000661294500001
PM 33472162
DA 2026-07-24
ER
PT J
AU Reed, T
AF Reed, Terri
TI The Use of Multiple Negative Pressure Wound Therapy Modalities to Help
   Manage Extensive Wounds Caused by a Crush/Sheer Injury
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time; acute
   wounds; trauma; lower extremity wound
AB Introduction. Vehicular run-over accidents cause crushing and sheering forces that can result in fractures and cause extensive damage to the cutaneous layer of the skin and underlying soft tissues. These types of injuries present immense challenges that often require numerous treatment modalities for wound management. A complex case in which 2 distinct negative pressure wound therapy (NPWT) modalities were instrumental in helping manage extensive wounds resulting from extreme crushing/sheering forces is presented. Case Report. A 22-year-old male without prior medical history presented to the treating facility after falling and being crushed by a parade float. The patient had multiple fractures to the facial area and pelvic region, including the left side of the sacrum. The injuries encompassed the entire perineum, rectal area, scrotum, and both upper legs. After stabilizing the patient, attention was directed to the extensive wound and eventual closure. Following muscle flap reconstructions to help protect the left and right femoral arteries, an acellular artificial skin was placed to cover the perineum, bilateral medial thighs, and left groin region. Upon developing wound complications, NPWT with instillation and dwell time (NPWTi-d) was applied by intermittently instilling 60 mL of normal saline solution with a 10-minute dwell time, followed by negative pressure at -125 mm Hg for 3.5 hours. The therapy was applied for 11 days with dressing changes every 2 to 3 days. The patient then underwent split-thickness skin grafting to the left thigh, perineum, and right thigh. Due to the extensive nature of the wounds and the multiple anatomical locations, a novel 4-channel NPWT system was used as a bolster over the skin grafts. Continuous NPWT was applied at -125 mm Hg for 2 weeks with dressing changes occurring every 2 to 3 days. There was complete take of all skin grafts 17 days post-grafting, and the patient has since healed. The patient is now walking and has resumed normal daily activities. Conclusions. For this case, combining treatment modalities was beneficial in healing a patient's complex trauma wounds and shows a potential treatment strategy in this population of wounds.
C1 [Reed, Terri] Barnes Jewish Hosp, Wound Ost, 1 Barnes Jewish Hosp Plaza, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Barnes-Jewish Hospital
RP Reed, T (通讯作者)，Barnes Jewish Hosp, Wound Ost, 1 Barnes Jewish Hosp Plaza, St Louis, MO 63110 USA.
EM terri.reed@BJC.org
CR Anghel EL, 2016, INT WOUND J, V13, P19, DOI 10.1111/iwj.12664
   Kaplan M, 2009, ADV SKIN WOUND CARE, V22, P128, DOI 10.1097/01.ASW.0000305451.71811.d5
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Omar M, 2016, J WOUND CARE, V25, P475, DOI 10.12968/jowc.2016.25.8.475
   Streubel PN, 2012, J AM ACAD ORTHOP SUR, V20, P564, DOI 10.5435/JAAOS-20-09-564
NR 5
TC 1
Z9 1
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2020
VL 32
SU S
BP 369
EP 371
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SR8KO
UT WOS:000661294500002
PM 33472163
DA 2026-07-24
ER
PT J
AU Scarpa, C
   de Antoni, E
   Vindigni, V
   Bassetto, F
AF Scarpa, Carlotta
   de Antoni, Eleonora
   Vindigni, Vincenzo
   Bassetto, Franco
TI Efficacy of Negative Pressure Wound Therapy With Instillation and Dwell
   Time for the Treatment of a Complex Chronic Venous Leg Ulcer
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time; venous
   leg ulcer; chronic wound; infected ulcer
AB Introduction. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) of topical solutions is a useful method for managing difficult-to-heal wounds, particularly for contaminated chronic ulcers. Most patients with chronic ulcers are affected by several pathologies that systemically impair wound healing; local slough and bacteria further increase the risk of treatment failure. Case Report. A 57-year-old male with obesity, diabetes, and heart disease presented with infected venous leg ulcers of 2 years' duration. The patient came to the authors' attention after unsuccessful treatment with advanced wound care dressings. The patient underwent surgical debridement and application of NPWTi-d with saline solution (settings: -100 mm Hg, 32 mL of instilled volume, 10-minute dwell time, and 2-hour cycle length) for 16 days. This resulted in good granulation tissue formation on the wound bed, so a meshed skin graft was used to cover the wound. In order to improve the skin graft take, the authors dressed it with polyvinyl alcohol foam connected to a traditional NPWT device (settings: -75 mm Hg, continuous pressure) for 1 week. After this period, complete wound healing was achieved, and the wound remained closed and stable upon follow-up. Conclusions. In the authors' opinion, NPWTi-d of topical solutions can be very useful in order to enhance debridement and reduce bacterial load. This kind of treatment allowed the authors to obtain a very good wound bed, and its application was very quick and easy to use, with no adverse events.
C1 [Scarpa, Carlotta; de Antoni, Eleonora; Vindigni, Vincenzo; Bassetto, Franco] Univ Hosp Padova, Inst Plast Surg, Padua, Italy.
C3 University of Padua; Azienda Ospedaliera - Universita di Padova
RP Scarpa, C (通讯作者)，Inst Plast Surg, Neurosci, Via Gustinani 2, I-35100 Padua, Italy.
EM carlotta.scarpa@unipd.it
RI /P-9974-2019; Vindigni, Vincenzo/K-5059-2016; Scarpa,
   Carlotta/HJG-7233-2022
CR Anghel EL, 2016, INT WOUND J, V13, P19, DOI 10.1111/iwj.12664
   Bassetto F, 2012, J PLAST RECONSTR AES, V65, P91, DOI 10.1016/j.bjps.2011.08.016
   Gabriel Allen, 2014, Eplasty, V14, pe41
   Gupta S, 2016, INT WOUND J, V13, P159, DOI 10.1111/iwj.12452
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Kim PJ, 2015, Wounds, V27, pS2
   Lessing MC, 2013, EPLASTY, V13, pe51
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   Yang C, 2017, WOUNDS, V29, P240
NR 11
TC 1
Z9 1
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2020
VL 32
SU S
BP 372
EP 374
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SR8KO
UT WOS:000661294500003
PM 33472164
DA 2026-07-24
ER
PT J
AU Ali, M
   Reda, FM
   Issaoui, H
   Abbassi, H
   Gargouri, M
   Razanabola, F
AF Ali, Mazen
   Reda, Fekhaoui Mohammed
   Issaoui, Hichem
   Abbassi, Hatem
   Gargouri, Mahdi
   Razanabola, Fredson
TI Management of a High-Energy Soft Tissue Injury of the Lower Extremity
   Using Negative Pressure Wound Therapy With Instillation and Dwell Time
   and a Reticulated Open Cell Foam Dressing: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time; NPWT;
   debridement; necrotic tissue
AB Introduction. Soft tissue injuries of the lower extremity are the result of high-energy trauma, such as road accidents, and remain challenging for most orthopedic surgeons. Proper selection of the treatment is important considering the risk of delayed necrosis and wound sepsis. Negative pressure wound therapy (NPWT) has improved complex wound treatment since 1997, but all treatments present advantages and limits. Case Report. A 21-year-old male presented with a high-energy soft tissue injury of the lower extremity. Three days after surgical debridement, complete skin necrosis developed. Successive surgical debridement was done in combination with traditional NPWT for 2 weeks; yet the wound did not progress toward healing, and the bone remained exposed. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) was used with a novel reticulated open cell foam dressing (ROCF-CC) because further surgical debridement was not possible, and the use of NPWT was not recommended by the French high authority for health. Growth of granulation tissue was fast (9 days), even over the bone, without any surgical debridement and despite the presence of nonviable and fibrinous tissue. After that, traditional NPWT was discontinued and a split-thickness skin graft then was used to cover the defects. Four weeks following the accident, all wounds were completely healed. Conclusions. Surgical debridement remains irreplaceable; however, when debridement is not feasible, NPWTi-d with ROCF-CC might be the treatment of choice. This strategy allowed the authors to ensure coverage of an extensive loss of soft tissue when the traditional NPWT limit was reached.
C1 [Ali, Mazen; Issaoui, Hichem; Abbassi, Hatem; Gargouri, Mahdi; Razanabola, Fredson] Reg Hosp Orleans, Dept Orthoped Surg & Trauma, Orleans, France.
   [Reda, Fekhaoui Mohammed] Mohammed V Univ Rabat, Ibn Sina Univ Hosp, Fac Med, Dept Trauma & Orthopaed Surg, Rabat, Morocco.
C3 Centre Hospitalier Universitaire d'Orleans; Mohammed V University in
   Rabat; Ibn sina University Hospital Center of Rabat
RP Reda, FM (通讯作者)，Mohammed V Univ Rabat, Ibn Sina Univ Hosp, Fac Med Rabat, Rabat 10100, Morocco.
EM rfekhaoui@icloud.com
CR Arnez ZM, 2010, J PLAST RECONSTR AES, V63, P1865, DOI 10.1016/j.bjps.2009.11.029
   Barla M, 2017, ORTHOP TRAUMATOL-SUR, V103, P971, DOI 10.1016/j.otsr.2017.05.022
   Blome-Eberwein S, 2018, Burns Open, V2, P208, DOI [10.1016/j.burnso.2018.05.004, 10.1016/j.burnso.2018.05.004, DOI 10.1016/J.BURNSO.2018.05.004]
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   Kim PJ, 2018, WOUNDS, pS1
   Liu DX, 2012, J TRAUMA ACUTE CARE, V73, P209, DOI 10.1097/TA.0b013e31824bac22
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   Runkel N, 2011, INJURY, V42, pS1, DOI 10.1016/S0020-1383(11)00041-6
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   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
NR 11
TC 5
Z9 6
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2020
VL 32
SU S
BP 375
EP 377
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SR8KO
UT WOS:000661294500004
PM 33472165
DA 2026-07-24
ER
PT J
AU Tsuji, S
   Ikai, A
   Oyama, K
   Kin, H
   Koizumi, J
AF Tsuji, Shigeto
   Ikai, Akio
   Oyama, Kotaro
   Kin, Hajime
   Koizumi, Junichi
TI Outcomes of primary sternal closure for postoperative mediastinitis in
   children
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Postoperative mediastinitis; Primary sternal closure; Delayed sternal
   closure; Pectoralis major muscle flaps; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAP; MANAGEMENT; INFECTION; RUPTURE;
   INFANTS
AB OBJECTIVES: We retrospectively analysed outcomes of debridement and primary sternal closure for postoperative mediastinitis in children.
   METHODS: Between January 2007 and July 2019, 1285 patients under the age of 20years underwent congenital heart surgery at the Iwate Medical University. Of these, 22 children had postoperative mediastinitis (1.7%). We performed adequate debridement and primary sternal closure with pectoralis major muscle advancement flaps. We evaluated hospital survival rates, reintervention, duration of intravenous antibiotic treatment, intensive care unit (ICU) stay and hospital stay.
   RESULTS: The median age and weight at surgery were 12.5months (range 0-228 months) and 7.8 kg (range 2.2-64.2 kg), respectively. Two patients (9%) had a history of delayed sternal closure. Staphylococcus was the most common causative agent for infection (82%). All cases were categorized as Robicsek's classification type II mediastinitis. The hospital survival rate was 95%, and freedom from reintervention for infectious complications was observed in 91% of the patients. The median durations of intravenous antibiotic treatment, ICU stay and hospital stay were 18 days (range 9-46 days), 4 days (range 1-87 days) and 22.5 days (range 11-87 days). The median follow-up time was 89 months (range 2-148 months), and there was no evidence of recurrent mediastinitis, musculoskeletal growth, physical deformity, breast development and upper trunk or limb movement.
   CONCLUSIONS: Primary sternal closure is an effective procedure for children as it can significantly shorten treatment duration and reduce physical and psychological burdens. Its results compare favourably with those of conventional therapy in terms of mortality and complications.
C1 [Tsuji, Shigeto; Kin, Hajime; Koizumi, Junichi] Iwate Med Univ, Dept Cardiovasc Surg, Morioka, Iwate, Japan.
   [Ikai, Akio] Mt Fuji Shizuoka Childrens Hosp, Dept Cardiovasc Surg, Shizuoka, Japan.
   [Oyama, Kotaro] Iwate Med Univ, Dept Pediat, Morioka, Iwate, Japan.
C3 Iwate Medical University; Iwate Medical University
RP Koizumi, J (通讯作者)，Iwate Med Univ, Dept Cardiovasc Surg, 2-1-1 Idaidori, Yahaba, Iwate 0283695, Japan.
EM jkoizumi@iwate-med.ac.jp
RI Tsuji, Shigeto/OGP-9757-2025
OI Koizumi, Junichi/0000-0002-3940-8957
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
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   BACKER CL, 1994, ANN THORAC SURG, V57, P797, DOI 10.1016/0003-4975(94)90179-1
   Erez E, 2000, ANN THORAC SURG, V69, P572, DOI 10.1016/S0003-4975(99)01075-9
   Fleck Tatjana, 2006, Interact Cardiovasc Thorac Surg, V5, P285, DOI 10.1510/icvts.2005.122424
   Kadohama T, 2008, ANN THORAC SURG, V85, P1094, DOI 10.1016/j.athoracsur.2007.09.004
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NR 15
TC 2
Z9 2
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD MAY
PY 2021
VL 59
IS 5
BP 951
EP 957
DI 10.1093/ejcts/ezaa477
EA FEB 2021
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA SR9CS
UT WOS:000661342500003
PM 33576375
OA Bronze
DA 2026-07-24
ER
PT J
AU Jiang, ZY
   Yu, XT
   Liao, XC
   Liu, MZ
   Fu, ZH
   Min, DH
   Guo, GH
AF Jiang, Zheng-Ying
   Yu, Xiao-Ting
   Liao, Xin-Cheng
   Liu, Ming-Zhuo
   Fu, Zhong-Hua
   Min, Ding-Hong
   Guo, Guang-Hua
TI Negative-pressure wound therapy in skin grafts: A systematic review and
   meta-analysis of randomized controlled trials
SO BURNS
LA English
DT Review
DE Negative-pressure therapy; Skin grafting; Systematic review;
   Meta-analysis
ID VACUUM-ASSISTED CLOSURE; INTEGRATION
AB Introduction: Although skin grafts are widely used in reconstruction of large skin defect and complex wounds, many factors lead to suboptimal graft take. Negative-pressure wound therapy (NPWT) reportedly increases the graft take rates when added to skin grafting, but a summary analysis of the data of randomized controlled trials has yet to be performed. We conducted this systematic review and meta-analysis of randomized controlled trials to compare the effectiveness and safety of NPWT and non-NPWT for patients with skin grafts.
   Methods: We searched PubMed, Embase, Cochrane Library, and CNKI for relevant trials based on predetermined eligibility criteria from database establishment to February 2020. Two reviewers screened citations and extracted data independently. The quality of the included studies was evaluated according to the Cochrane Handbook, whereas statistical heteroge-neity was assessed using chi-square tests and I2 statistics. Review Manager 5.3 was used for statistical analysis.
   Results: Ten randomized controlled trials with 488 patients who underwent NPWT or non-NPWT were included. Compared with non-NPWT, NPWT yielded an improved the percentage of graft take, a reduction in days from grafting to discharge, with lower relative risk of re-operation, and no increased relative risk of adverse event. Further, the subgroup analysis showed an improved the percentage of graft take in negative pressure of 80 mmHg, and no improved the percentage of graft take in negative pressure of 125 mmHg.
   Conclusion: NPWT is more effective than non-NPWT for the integration of skin grafts, and the negative pressure of 80 mmHg can be recommended. Data on adverse events and negative pressure are, however, limited. A better understanding of complications after NPWT and the ideal negative pressure for the integration of skin grafts is imperative.
   (c) 2021 Elsevier Ltd and ISBI. All rights reserved.
C1 [Jiang, Zheng-Ying; Yu, Xiao-Ting; Liao, Xin-Cheng; Liu, Ming-Zhuo; Fu, Zhong-Hua; Min, Ding-Hong; Guo, Guang-Hua] Nanchang Univ, Dept Burn, Affiliated Hosp 1, 17 Yong Wai St, Nanchang 330006, Jiangxi, Peoples R China.
C3 Nanchang University
RP Guo, GH (通讯作者)，Nanchang Univ, Dept Burn, Affiliated Hosp 1, 17 Yong Wai St, Nanchang 330006, Jiangxi, Peoples R China.
EM guoghtg@sina.com
FU National Natural Science Foundation of China [81960352, 81760342];
   Special Fund for Innovation of Postgraduates in Jiangxi Province, China
   [YC2020B039]; Key Program of Jiangxi Provincial Natural Science
   Foundation, China [20171ACB20031]
FX This work was supported by the National Natural Science Foundation of
   China (81760342) , the National Natural Science Foundation of China
   (81960352) , the Special Fund for Innovation of Postgraduates in Jiangxi
   Province, China (YC2020B039) , and the Key Program of Jiangxi Provincial
   Natural Science Foundation, China (20171ACB20031) .
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NR 29
TC 29
Z9 36
U1 1
U2 4
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD JUN
PY 2021
VL 47
IS 4
BP 747
EP 755
DI 10.1016/j.burns.2021.02.012
EA JUN 2021
PG 9
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA SS0QY
UT WOS:000661448400003
PM 33814213
DA 2026-07-24
ER
PT J
AU Wotton, R
   Garner, M
   Salem, A
   Buderi, S
AF Wotton, Robin
   Garner, Megan
   Salem, Agni
   Buderi, Silviu
TI Is open window thoracostomy the only method to control infection in
   patients with an empyema following pulmonary resection for primary lung
   cancer?
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Empyema; Lobectomy; Open window thoracostomy; Conservative management
ID MANAGEMENT
AB A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed: Is open window thoracostomy (OWT) the only method to control infection in patients with an empyema following pulmonary resection for primary lung cancer? Altogether 442 papers were found using the reported search, of which 9 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Empyema following anatomical lung resection (excluding pneumonectomy) is an uncommon complication but one that remains a challenge to treat effectively. Chest tube thoracostomy and intravenous antibiotics remain the initial steps to management, but evidence is lacking with regard to the best ongoing strategy. Conservative options including chest cavity irrigation, postural drainage and vacuum-assisted closure have been attempted with some success, even in the presence of a broncho-pleural fistula. However, the very limited number of patients on which these various management strategies have been trialled on prevents recommendations and clear guidance being given.
C1 [Wotton, Robin; Garner, Megan; Salem, Agni] Liverpool Heart & Chest Hosp, Dept Thorac Surg, Liverpool L14 3PE, Merseyside, England.
   [Buderi, Silviu] Royal Brompton & Harefield, Dept Thorac Surg, London, England.
C3 Liverpool Heart & Chest Hospital; Royal Brompton Hospital
RP Wotton, R (通讯作者)，Liverpool Heart & Chest Hosp, Dept Thorac Surg, Liverpool L14 3PE, Merseyside, England.
EM robin.wotton@lhch.nhs.uk
CR Al-Mufarrej F, 2010, SURG TODAY, V40, P711, DOI 10.1007/s00595-008-4096-9
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NR 10
TC 6
Z9 9
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUN
PY 2021
VL 32
IS 6
BP 928
EP 932
DI 10.1093/icvts/ivab009
EA FEB 2021
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA SS1AR
UT WOS:000661474500013
PM 33570150
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Meshkin, DH
   Fan, KL
   Charipova, K
   Hill, C
   Evans, KK
   Steinberg, JS
   Kim, PJ
   Attinger, CE
AF Meshkin, Dean H. Y.
   Fan, Kenneth L.
   Charipova, Karina
   Hill, Christine
   Evans, Karen K.
   Steinberg, John S.
   Kim, Paul J.
   Attinger, Christopher E.
TI Long-Term Outcome Assessment Between Antiseptic and Normal Saline for
   Negative Pressure Wound Therapy with Instillation
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE wound healing; negative pressure wound therapy; normal saline; complex
   wounds
ID DIABETIC FOOT; INTERNATIONAL CONSENSUS; TOBACCO
AB Objective: To analyze long-term outcomes following inpatient treatment of infected wounds with antimicrobial or normal saline instillation during negative pressure wound therapy (NPWT).
   Approach: This was a single-center retrospective study analyzing the course of patients receiving 0.9% normal saline or 0.1% polyhexanide plus 0.1% betaine as instillation for wounds requiring surgery. Measured outcomes included rates of dehiscence, new wounds, re-operations, amputations, and mortality over 5 years. The article adheres to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement.
   Results: Forty-two patients received normal saline instillation and 41 the antiseptic solution. Rates of dehiscence, wound recurrence, and re-operations in the saline and antiseptic cohorts were 6.3% and 5.6%, 9.4% and 5.6%, and 14.3% and 9.8%, respectively (p > 0.05). In patients requiring further surgery, time to wound closure averaged 104 and 130 days in the saline and antiseptic cohorts, respectively (p = 0.81). Five-year amputation and mortality rates were 14.3% and 22% (p = 0.36) and 24% and 17% (p = 0.45) in the saline and antiseptic cohorts, respectively.
   Innovation: To compare clinical outcomes associated with two fundamentally different instillation solutions over the full wound care episode and elucidate the potential impact of these results for future applications.
   Conclusion: This is the first evaluation of nonsurrogate outcomes of different instillations for NPWT in infected wounds. The results indicate that normal saline instillation outcomes are comparable to those of 0.1% polyhexanide plus 0.1% betaine. The clinical success, cost benefit, and accessibility of normal saline can expand the utilization of this therapeutic approach for larger patient populations.
C1 [Meshkin, Dean H. Y.; Charipova, Karina; Hill, Christine] Georgetown Univ, Sch Med, Dept Plast & Reconstruct Surg, Washington, DC 20007 USA.
   [Fan, Kenneth L.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, Washington, DC USA.
   [Evans, Karen K.; Steinberg, John S.; Attinger, Christopher E.] MedStar Georgetown Univ Hosp, Ctr Wound Healing, Dept Plast & Reconstruct Surg, 3800 Reservoir Rd NW,First Floor PHC, Washington, DE 20007 USA.
   [Kim, Paul J.] William P Clements Jr Univ Hosp, Wound Care Ctr, Dept Plast Surg, Dallas, TX USA.
C3 Georgetown University; Georgetown University
RP Meshkin, DH (通讯作者)，Georgetown Univ, Sch Med, Dept Plast & Reconstruct Surg, Washington, DC 20007 USA.; Attinger, CE (通讯作者)，MedStar Georgetown Univ Hosp, Ctr Wound Healing, Dept Plast & Reconstruct Surg, 3800 Reservoir Rd NW,First Floor PHC, Washington, DE 20007 USA.
EM hr292@georgetown.edu; cattinger@aol.com
OI , Paul/0000-0002-6186-6890; Meshkin, Dean/0000-0002-8706-3690
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NR 40
TC 3
Z9 4
U1 0
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD OCT 1
PY 2021
VL 10
IS 10
BP 535
EP 543
DI 10.1089/wound.2021.0023
EA JUN 2021
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA TN1PX
UT WOS:000661609200001
PM 33860686
DA 2026-07-24
ER
PT J
AU Tang, XH
   Guo, PH
   Wong, HT
   Xie, JH
   Han, JD
   Xu, YB
   Zhou, H
AF Tang, Xuhua
   Guo, Penghao
   Wong, Hioteng
   Xie, Jiahui
   Han, Jiande
   Xu, Yingbin
   Zhou, Hui
TI Vacuum-Assisted Closure and Skin Grafting Combined with Amphotericin B
   for Successful Treatment of an Immunocompromised Patient with Cutaneous
   Mucormycosis Caused by Mucor irregularis: A Case Report and
   Literature Review
SO MYCOPATHOLOGIA
LA English
DT Review
DE Mucor irregularis; Rhizomucor variabilis; Amphotericin B; Cutaneous
   mucormycosis; Debridement; Negative-pressure wound therapy
ID RHIZOMUCOR-VARIABILIS; INFECTION; EPIDEMIOLOGY; SURGERY; AGENT
AB Cutaneous mucormycosis caused by Mucor irregularis (M. irregularis) is a rare condition that typically occurs in immunocompetent patients. Herein, we describe an immunocompromised patient with cutaneous M. irregularis infection who was successfully treated with debridement combined with vacuum assisted closure (VAC) negative pressure technique and split-thickness skin grafting. We present this case owing to its complexity and rarity and the successful treatment with surgical therapy. A 58-year-old man presented to our hospital with a history of skin ulcers and eschar on the right lower leg since two months. He had been receiving methylprednisolone therapy for bullous pemphigoid that occurred five months prior to the present lesions. Histopathological examination of a right leg lesion showed broad, branching hyphae in the dermis. Fungal culture and subsequent molecular cytogenetic analysis identified the pathogen as M. irregularis. After admission, methylprednisolone was gradually tapered and systemic treatment with amphotericin B (total dose 615 mg) initiated along with others supportive therapies. However, the ulcers showed no improvement, and amphotericin B had to be discontinued owing to development of renal dysfunction. After extensive surgical debridement combined with VAC and skin grafting, his skin ulcers were healed; subsequent fungal cultures of the lesions were negative. The patient exhibited no signs of recurrence at 36-month follow-up. Twenty-six cases with M. irregularis-associated cutaneous mucormycosis in literature were reviewed.
C1 [Tang, Xuhua; Wong, Hioteng; Han, Jiande; Zhou, Hui] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Dermatol, 58,Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.
   [Guo, Penghao] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Clin Lab, Guangzhou 510080, Peoples R China.
   [Xie, Jiahui] First Peoples Hosp Shaoguan, Dept Dermatol, Shaoguan 512000, Peoples R China.
   [Xu, Yingbin] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burns, 58,Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
RP Zhou, H (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Dept Dermatol, 58,Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.; Xu, YB (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burns, 58,Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.
EM txh0812@126.com; jackgph@163.com; hiotengwong@outlook.com;
   xiejiahuisg@163.com; hanjd58@126.com; 333xyb@163.com;
   zhouhongcai@126.com
RI ; Zhou, Hui/JCF-2570-2023
OI Wong, Hioteng/0009-0006-4215-7155; 
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   Yamaguchi S, 2015, J DERMATOL, V42, P210, DOI 10.1111/1346-8138.12736
   [张帅 Zhang Shuai], 2018, [中华皮肤科杂志, Chinese Journa of Dermatology], V51, P142, DOI 10.3760/cma.j.issn.0412-4030.2018.02.013
   Zhao Y, 2009, MYCOPATHOLOGIA, V168, P243, DOI 10.1007/s11046-009-9219-3
NR 34
TC 9
Z9 10
U1 0
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-486X
EI 1573-0832
J9 MYCOPATHOLOGIA
JI Mycopathologia
PD JUN
PY 2021
VL 186
IS 3
BP 449
EP 459
DI 10.1007/s11046-021-00551-3
EA JUN 2021
PG 11
WC Mycology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mycology
GA TC9CU
UT WOS:000661827200001
PM 34131870
DA 2026-07-24
ER
PT J
AU Klein, C
   Marie-Christine, P
   Deroussen, F
   Haraux, E
   Gouron, R
AF Klein, Celine
   Marie-Christine, Plancq
   Deroussen, Francois
   Haraux, Elodie
   Gouron, Richard
TI Treatment options for soft tissue defects in severe foot trauma in
   children
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE children; defect; flap; foot; Kitaoka score; limb reconstruction;
   negative pressure wound therapy; osteomyelitis; paediatric; paediatric
   reconstruction; reconstruction; skin defect; trauma; wound; wound
   defect; wound healing; wounds
ID LOWER-EXTREMITY RECONSTRUCTION; VACUUM-ASSISTED CLOSURE; PERFORATOR
   FLAPS; ANKLE; COVERAGE; VERSATILITY; INJURIES; INTEGRA
AB Objective: Severe foot trauma in children is a therapeutic challenge, with presence of devitalised and soiled distal tissues. Several reconstruction and covering procedures can be applied, including artificial dermis (AD), negative pressure wound therapy (NPWT), fasciocutaneous flaps and free flaps. Here, we have developed and evaluated an algorithm for treating severe foot injuries with skin defects in children
   Method: Paediatric cases of severe foot injury treated over a 16-year period were retrospectively reviewed. Characteristics of the injuries, surgical procedures, complications and the modified Kitaoka score (clinical and functional rating score of the ankle and foot) were recorded.
   Results: A total of 18 children were included. The mean age at the time of injury was four years and 10 months (range: 1-11 years). The mean follow-up period was 6.2 years. Of the children, 13 presented with an amputation (12 partial foot amputations and one whole ankle and foot). The skin defect was combined with tendon exposure in nine cases, and/or bone and cartilage in seven cases, and heel damage in two cases. A flap was implemented in eight cases, of which one failed. NPWT was used in 13 patients (for an average of 21 days) and was combined with AD in six patients. The mean modified Kitaoka score was 68 (range: 55-80). Additional surgery during the follow-up period was required in seven patients (dorsal skin retraction, a thick flap, osteoma, trophic ulcer or ankle deviation).
   Conclusion: Our algorithm suggests different therapeutic strategies for skin coverage and healing, depending on the size of the lesion and the exposed structures, and seems to offer good results. These procedures should be combined with NPWT to optimise these results (improved healing, reduced infections, decreased skin defects and enhanced granulation tissue) and so should be used more frequently.
C1 [Klein, Celine; Marie-Christine, Plancq; Deroussen, Francois; Haraux, Elodie; Gouron, Richard] Amiens Univ Hosp, Dept Paediat Orthopaed Surg, Amiens, France.
   [Klein, Celine; Marie-Christine, Plancq; Deroussen, Francois; Haraux, Elodie; Gouron, Richard] Jules Verne Univ Picardie, Amiens, France.
C3 Universite de Picardie Jules Verne (UPJV); CHU Amiens; Universite de
   Picardie Jules Verne (UPJV)
RP Klein, C (通讯作者)，Amiens Univ Hosp, Dept Paediat Orthopaed Surg, Amiens, France.; Klein, C (通讯作者)，Jules Verne Univ Picardie, Amiens, France.
EM elinekleinfr@yahoo.fr
RI HARAUX, Elodie/H-8240-2019; Gouron, Richard/AGM-3039-2022
CR Akhtar S, 2006, J PLAST RECONSTR AES, V59, P839, DOI 10.1016/j.bjps.2005.12.009
   Banwell P E, 2003, J Wound Care, V12, P22
   de Jesus LE, 2018, J PEDIATR SURG, V53, P585, DOI 10.1016/j.jpedsurg.2017.11.048
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Duteille F, 2003, ANN PLAS SURG, V50, P344, DOI 10.1097/01.SAP.0000044143.36516.32
   Eberl R, 2011, INJURY, V42, P1171, DOI 10.1016/j.injury.2009.08.005
   Fagelman MF, 2002, J PEDIATR ORTHOPED, V22, P182, DOI 10.1097/00004694-200203000-00009
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   KITAOKA HB, 1994, FOOT ANKLE INT, V15, P349, DOI 10.1177/107110079401500701
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   Lin CH, 2006, PLAST RECONSTR SURG, V117, P2478, DOI 10.1097/01.prs.0000219133.72059.71
   Low EE, 2017, INJURY, V48, P364, DOI 10.1016/j.injury.2016.11.019
   Marchaland JP, 2008, ANN CHIR PLAST ESTH, V53, P14, DOI 10.1016/j.anplas.2007.04.005
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   Pu LLQ, 2009, J PLAST RECONSTR AES, V62, pE682, DOI 10.1016/j.bjps.2008.08.032
   Raj M, 2016, J CLIN DIAGN RES, V10, pRC5, DOI 10.7860/JCDR/2016/17449.7598
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   VLASTOU C, 1995, ACTA ORTHOP SCAND, V66, P27
   Vollman D, 2006, PEDIATRICS, V118, pE273, DOI 10.1542/peds.2006-0056
   Wong JKF, 2017, J PLAST RECONSTR AES, V70, P67, DOI 10.1016/j.bjps.2016.09.028
NR 27
TC 4
Z9 5
U1 0
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2021
VL 30
IS 6
BP 432
EP 438
DI 10.12968/jowc.2021.30.6.432
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ST0ZV
UT WOS:000662180700004
PM 34121437
DA 2026-07-24
ER
PT J
AU O'Malley, P
   McDonnell, C
AF O'Malley, Paula
   McDonnell, Ciaran
TI Negative pressure wound therapy-two novel approaches to healing dehisced
   vascular bypass wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE bypass graft; diabetes; dressing; infection; negative pressure wound
   therapy.; surgical wound healing by secondary intention; vascular
   wounds; wound
ID VACUUM-ASSISTED CLOSURE; INFECTIONS
AB The use of negative pressure wound therapy (NPWT) in surgical wound healing by secondary intention is well known. Its use in healing dehisced vascular bypass wounds is contraindicated by manufacturers due to exposed vasculature and risk of bleeding. There is an increasing body of knowledge to support the use of NPWT in vascular wounds in order to prevent graft excision and the need for flap closure. This paper reports the use of two different approaches using NPWT to heal dehisced, infected vascular groin bypass wounds in two patients. Both patients had lower limb bypass using Dacron (Vascutek Ltd., UK) grafts and subsequently became infected, dehisced and required debridement. Following debridement, graft was visible in the wound bed and NPWT was applied to facilitate healing. Case one had polyurethane (black) foam and a layer of petroleum-impregnated cellulose acetate mesh to prevent adherence to the graft. Case two had polyvinyl alcohol (white) (PVA) foam applied to the wound. The PVA foam was used in Case two due to pain at dressing changes. Negative pressure was initially -25mmHg but increased gradually to -125mmHg and -150mmHg, respectively, the therapeutic pressure for the respective foams. Dressings were changed every 48-72 hours and infection treated with antibiotics as appropriate. After eight days and 28 days of NPWT, respectively, graft was no longer visible. No significant bleeding was noted. These two case studies would suggest that, with precautions taken to protect the vasculature, the use of NPWT in healing dehisced vascular groin wounds is an appropriate treatment.
C1 [O'Malley, Paula; McDonnell, Ciaran] Mater Private Hosp, Dublin, Ireland.
C3 Mater Private Hospital
RP O'Malley, P (通讯作者)，Mater Private Hosp, Dublin, Ireland.
EM paula.omalley@materprivate.ie
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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   Dowsett C., 2012, WOUNDS UK, V8, P48
   Dumville JC, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011278.pub2
   Henderson V., 2010, WOUNDS INT, V1, P1
   KCI, 2015, VAC THER CLIN GUID R
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Lakhiani C, 2019, J VASC SURG CASES IN, V5, P435, DOI 10.1016/j.jvscit.2019.04.008
   McNulty AK, 2007, WOUND REPAIR REGEN, V15, P838, DOI 10.1111/j.1524-475X.2007.00287.x
   Monsen C, 2014, J VASC SURG, V59, P145, DOI 10.1016/j.jvs.2013.06.073
   Peart J., 2019, WOUNDS UK, V15, P20
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
   Tan KW, 2017, ANN VASC DIS, V10, P386, DOI 10.3400/avd.oa.17-00052
   Thorbjornsen K, 2016, EUR J VASC ENDOVASC, V51, P724, DOI 10.1016/j.ejvs.2016.01.011
   Williams IM, 2003, EUR J VASC ENDOVASC, V25, P390, DOI 10.1053/ejvs.2002.1890
NR 17
TC 1
Z9 1
U1 0
U2 9
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2021
VL 30
IS 6
BP 449
EP 453
DI 10.12968/jowc.2021.30.6.449
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ST0ZV
UT WOS:000662180700006
PM 34121434
DA 2026-07-24
ER
PT J
AU Hajjar, MS
   Atallah, GM
   Oneissi, A
   Beaineh, P
   Abu-Sittah, GS
AF Hajjar, Marwan S.
   Atallah, Georgio M.
   Oneissi, Ahmad
   Beaineh, Paul
   Abu-Sittah, Ghassan S.
TI What is the role of incisional vacuum therapy in challenging spinal
   wounds? A single centre experience
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE diabetes; dressing; incisional vacuum therapy; infection; negative
   pressure wound therapy; spinal surgery; spine; wound; wound
   complications; wound healing
ID SURGICAL SITE INFECTION; ASSISTED CLOSURE; RISK-FACTORS; POSTOPERATIVE
   COMPLICATIONS; EPIDURAL HEMATOMA; LUMBAR SPINE; SURGERY; MANAGEMENT;
   IMPACT
AB Objective: A surgical approach to the treatment of spinal defects and disorders has become more common because of the medical and technological advancements achieved in the last decade. This rising trend in spinal surgeries is associated with adverse events, most notably wound complications. From its introduction, negative pressure wound therapy (NPWT) has proved to be essential in the management of complex wounds and in speeding up wound recovery. The aim of this study is to investigate the use of incisional NPWT in patients undergoing spinal surgery and its role in the prevention of wound complications.
   Method: This study is a retrospective medical chart review conducted on patients who underwent spinal surgery and received incisional vacuum therapy as part of their treatment. The apparatus was applied intraoperatively following the spinal surgery for all patients included in this study. All surgical procedures were conducted between September 2019 and May 2020. Data entry and analysis were performed between September and October 2020.
   Results: A total of five patients' records were reviewed. In our healthcare centre, three patients developed seroma, one developed haematoma, four required revision surgery and one patient required re-operation. There was no wound dehiscence and none of the wounds became infected. Mean length of hospital stay was 11.2 days (standard deviation (SD): 9.5 days) and mean operation time was 333 minutes (SD: 86.4 minutes).
   Conclusion: There is a scarcity of data on the role of incisional vacuum therapy in the prevention of wound complications associated with spine surgeries. Our study showed promising results for the use of incisional NPWT in the management of spinal wounds. Further research is required in order to enhance wound care by exploiting this potentially beneficial approach.
C1 [Hajjar, Marwan S.; Atallah, Georgio M.; Oneissi, Ahmad; Beaineh, Paul] Amer Univ Beirut, Dept Surg, Div Plast Surg, Med Ctr, Beirut, Lebanon.
   [Abu-Sittah, Ghassan S.] Amer Univ Beirut, Global Hlth Inst, Conflict Med Program, Beirut, Lebanon.
C3 American University of Beirut; American University of Beirut
RP Abu-Sittah, GS (通讯作者)，Amer Univ Beirut, Global Hlth Inst, Conflict Med Program, Beirut, Lebanon.
EM Ghassan.s.abusittah@gmail.com
RI Abu-Sittah, Ghassan/AAE-3169-2020
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NR 53
TC 4
Z9 4
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2021
VL 30
IS 6
BP 476
EP 481
DI 10.12968/jowc.2021.30.6.476
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ST0ZV
UT WOS:000662180700010
PM 34121438
DA 2026-07-24
ER
PT J
AU Willms, AG
   Schaaf, S
   Zimmermann, N
   Schwab, R
   Güsgen, C
   Vilz, TO
   Kalff, JC
   von Websky, MW
AF Willms, Arnulf G.
   Schaaf, Sebastian
   Zimmermann, Nicolay
   Schwab, Robert
   Guesgen, Christoph
   Vilz, Tim O.
   Kalff, Joerg C.
   von Websky, Martin W.
TI The Significance of Visceral Protection in Preventing Enteroatmospheric
   Fistulae During Open Abdomen Treatment in Patients With Secondary
   Peritonitis A Propensity Score-matched Case-control Analysis
SO ANNALS OF SURGERY
LA English
DT Article
DE abdominal compartment syndrom; enteroatmospheric fistulae; negative
   pressure wound therapy; open abdomen; peritonitis; trauma
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; MEDIATED FASCIAL
   TRACTION; TEMPORARY ABDOMINAL CLOSURE; PROGNOSTIC-FACTORS; MANAGEMENT;
   CLASSIFICATION
AB Objective: To evaluate the influence of a visceral protective layer (VPL) on the formation of enteroatmospheric fistulae (EAF) in open abdomen treatment (OAT) for peritonitis. Background: EAF formation is a severe complication of OAT. Despite the widespread use of OAT, there are no robust evidence-based recommendations for preventing EAF. Methods: A total of 120 peritonitis patients with secondary peritonitis as a result of a perforation of a hollow viscus or anastomotic insufficiency who had undergone OAT were included, and 14 clinical parameters were recorded in prospective OAT databases at 2 tertiary referral centers. For this analysis, patients with a VPL were assigned to the treatment group and those without a VPL to the control group. Propensity Score (PS) matching was performed. Known risk factors in OAT such as malignant disease, mortality, emergency operation, OAT duration, and fascial closure were matching variables. The influence of VPL on EAF formation was statistically evaluated using logistic regression analysis. Results: With 34 patients in each group, no notable differences were identified with regard to age, sex, underlying disease, mortality, emergency operation, fascial closure, and OAT duration. Overall, a mortality rate of 22.1% for OAT due to peritonitis was observed. Mean OAT duration was approximately 9 days, and secondary fascial closure was achieved in more than two-thirds of all patients. Fascial traction was used in more than 75% of cases. EAF formation was significantly more frequent in the control group (EAF formation: VPL group 2.9% vs control 26.5%; P = 0.00). In the final regression analysis, the use of VPL resulted in a significant reduction in the risk of EAF formation (odds ratio 0.08; 95% confidence interval 0.01-0.71, P = 0.02), which translates to a relative risk reduction of 89.1%. Conclusion: VPL effectively prevents EAF formation during OAT in patients with peritonitis. We recommend the consistent use of VPL as part of a standardized OAT treatment algorithm.
C1 [Vilz, Tim O.; Kalff, Joerg C.; von Websky, Martin W.] Univ Hosp Bonn, Dept Surg, Bonn, Germany.
   [Willms, Arnulf G.; Schaaf, Sebastian; Zimmermann, Nicolay; Schwab, Robert; Guesgen, Christoph] German Armed Forces Cent Hosp, Dept Gen Visceral & Thorac Surg, Koblenz, Germany.
C3 University of Bonn
RP Willms, AG (通讯作者)，German Armed Forces Cent Hosp, Dept Gen Visceral & Thorac Surg, Koblenz, Germany.
EM ArnulfWillms@gmx.de
RI Willms, Arnulf/AFN-0812-2022; von Websky, Martin/AFC-6767-2022; Kalff,
   Joerg/U-8580-2017
OI Willms, Arnulf/0000-0001-9998-6735; 
CR Acosta S, 2016, EUR J VASC ENDOVASC, V51, P371, DOI 10.1016/j.ejvs.2015.10.014
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NR 28
TC 19
Z9 23
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JUN
PY 2021
VL 273
IS 6
BP 1182
EP 1188
DI 10.1097/SLA.0000000000003440
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ST2UC
UT WOS:000662304000042
PM 31318792
DA 2026-07-24
ER
PT J
AU Wagner, JC
   Wetz, A
   Wiegering, A
   Lock, JF
   Löb, S
   Germer, CT
   Klein, I
AF Wagner, Johanna C.
   Wetz, Anja
   Wiegering, Armin
   Lock, Johan F.
   Lob, Stefan
   Germer, Christoph-Thomas
   Klein, Ingo
TI Successful surgical closure of infected abdominal wounds following
   preconditioning with negative pressure wound therapy
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Surgical site infections; Secondary skin closure; Negative pressure
   wound therapy; Open wound treatment
ID VACUUM-ASSISTED CLOSURE; SITE INFECTION; SECONDARY INTENTION; OPEN
   ABDOMEN; COMPLICATIONS; IMPACT; MANAGEMENT; HERNIA; COSTS; INDEX
AB Purpose Traditionally, previous wound infection was considered a contraindication to secondary skin closure; however, several case reports describe successful secondary wound closure of wounds "preconditioned" with negative pressure wound therapy (NPWT). Although this has been increasingly applied in daily practice, a systematic analysis of its feasibility has not been published thus far. The aim of this study was to evaluate secondary skin closure in previously infected abdominal wounds following treatment with NPWT. Methods Single-center retrospective analysis of patients with infected abdominal wounds treated with NPWT followed by either secondary skin closure referenced to a group receiving open wound therapy. Endpoints were wound closure rate, wound complications (such as recurrent infection or hernia), and perioperative data (such as duration of NPWT or hospitalization parameters). Results One hundred ninety-eight patients during 2013-2016 received a secondary skin closure after NPWT and were analyzed and referenced to 67 patients in the same period with open wound treatment after NPWT. No significant difference in BMI, chronic immunosuppressive medication, or tobacco use was found between both groups. The mean duration of hospital stay was 30 days with a comparable duration in both patient groups (29 versus 33 days, p = 0.35). Interestingly, only 7.7% of patients after secondary skin closure developed recurrent surgical site infection and in over 80% of patients were discharged with closed wounds requiring only minimal outpatient wound care. Conclusion Surgical skin closure following NPWT of infected abdominal wounds is a good and safe alternative to open wound treatment. It prevents lengthy outpatient wound therapy and is expected to result in a higher quality of life for patients and reduce health care costs.
C1 [Wagner, Johanna C.; Wetz, Anja; Wiegering, Armin; Lock, Johan F.; Lob, Stefan; Germer, Christoph-Thomas; Klein, Ingo] Univ Hosp Wurzburg, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Oberduerrbacherstr 6, D-97080 Wurzburg, Germany.
   [Wiegering, Armin; Lock, Johan F.; Lob, Stefan; Germer, Christoph-Thomas; Klein, Ingo] Comprehens Canc Ctr Mainfranken, Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg
RP Wagner, JC (通讯作者)，Univ Hosp Wurzburg, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Oberduerrbacherstr 6, D-97080 Wurzburg, Germany.
EM Wagner_J6@ukw.de
RI Wagner, Johanna/KOD-4870-2024; Klein, Ingo/AAY-3371-2020; Lock,
   Johan/AAA-8114-2020; Wiegering, Armin/X-7541-2018
OI Wagner, Johanna/0000-0002-2999-6900; Klein, Ingo/0000-0003-1097-0986;
   Lock, Johan/0000-0002-9007-3937; Wiegering, Armin/0000-0001-7777-0909
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 43
TC 8
Z9 10
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD NOV
PY 2021
VL 406
IS 7
BP 2479
EP 2487
DI 10.1007/s00423-021-02221-w
EA JUN 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WU6XB
UT WOS:000662867000001
PM 34142218
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Coccolini, F
   Improta, M
   Cicuttin, E
   Catena, F
   Sartelli, M
   Bova, R
   de' Angelis, N
   Gitto, S
   Tartaglia, D
   Cremonini, C
   Ordonez, C
   Baiocchi, GL
   Chiarugi, M
AF Coccolini, Federico
   Improta, Mario
   Cicuttin, Enrico
   Catena, Fausto
   Sartelli, Massimo
   Bova, Raffaele
   de' Angelis, Nicola
   Gitto, Stefano
   Tartaglia, Dario
   Cremonini, Camilla
   Ordonez, Carlos
   Baiocchi, Gian Luca
   Chiarugi, Massimo
TI Surgical site infection prevention and management in immunocompromised
   patients: a systematic review of the literature
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Infection; Immunity; Wound; Care; Costs; Drugs; Inflammatory
ID PRESSURE WOUND THERAPY; METASTATIC COLORECTAL-CANCER; LIVER-TRANSPLANT
   RECIPIENTS; RISK-FACTORS; KIDNEY-TRANSPLANT; IMMUNOSUPPRESSIVE THERAPY;
   ANTIBIOTIC-PROPHYLAXIS; RENAL-TRANSPLANTATION; HEALING COMPLICATIONS;
   SURGERY
AB Background Immunocompromised patients are at higher risk of surgical site infection and wound complications. However, optimal management in the perioperative period is not well established. Present systematic review aims to analyse existing strategies and interventions to prevent and manage surgical site infections and other wound complications in immunocompromised patients. Methods A systematic review of the literature was conducted. Results Literature review shows that partial skin closure is effective to reduce SSI in this population. There is not sufficient evidence to definitively suggest in favour of prophylactic negative pressure wound therapy. The use of mammalian target of rapamycin (mTOR) and calcineurin inhibitors (CNI) in transplanted patient needing ad emergent or undeferrable abdominal surgical procedure must be carefully and multidisciplinary evaluated. The role of antibiotic prophylaxis in transplanted patients needs to be assessed. Conclusion Strict adherence to SSI infection preventing bundles must be implemented worldwide especially in immunocompromised patients. Lastly, it is necessary to elaborate a more widely approved definition of immunocompromised state. Without such shared definition, it will be hard to elaborate the needed methodologically correct studies for this fragile population.
C1 [Coccolini, Federico; Cicuttin, Enrico; Tartaglia, Dario; Cremonini, Camilla; Chiarugi, Massimo] Pisa Univ Hosp, Gen Emergency & Trauma Surg Dept, Via Paradisa 1, I-56100 Pisa, Italy.
   [Improta, Mario; Bova, Raffaele] Bologna Univ Hosp, Gen Surg Dept, Bologna, Italy.
   [Catena, Fausto] Parma Univ Hosp, Emergency Surg Dept, Parma, Italy.
   [Sartelli, Massimo] Macerata Hosp, Gen Surg Dept, Macerata, Italy.
   [de' Angelis, Nicola] Henri Mondor Hosp, Unit Digest & Hepatobiliary Pancreat Surg, Creteil, France.
   [de' Angelis, Nicola] Univ Paris Est, UPEC, Creteil, France.
   [Gitto, Stefano] Firenze Univ, Dept Expt & Clin Med, Florence, Italy.
   [Ordonez, Carlos] Fdn Valle Lili, Dept Surg, Cali, Colombia.
   [Baiocchi, Gian Luca] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.
C3 University of Pisa; Azienda Ospedaliero Universitaria Pisana; IRCCS
   Azienda Ospedaliero-Universitaria di Bologna; University of Parma;
   University Hospital of Parma; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Fundacion Valle del Lili; University of Brescia
RP Coccolini, F (通讯作者)，Pisa Univ Hosp, Gen Emergency & Trauma Surg Dept, Via Paradisa 1, I-56100 Pisa, Italy.
EM Federico.coccolini@gmail.com
RI Tartaglia, Dario/AAJ-1735-2020; de'Angelis, Nicola/Q-7759-2016;
   Cicuttin, Enrico/GXG-6365-2022; Coccolini, Federico/AAJ-6507-2020;
   Chiarugi, Massimo/ABQ-7280-2022; Gitto, Stefano/J-9922-2018;
   /AAD-7440-2020
OI de'Angelis, Nicola/0000-0002-1211-4916; Cicuttin,
   Enrico/0000-0003-4584-9940; Coccolini, Federico/0000-0001-6364-4186;
   Chiarugi, Massimo/0000-0001-6905-2499; Gitto,
   Stefano/0000-0002-8042-6508; 
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NR 78
TC 41
Z9 50
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JUN 10
PY 2021
VL 16
IS 1
AR 33
DI 10.1186/s13017-021-00375-y
PG 13
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA SV4NH
UT WOS:000663797200003
PM 34112231
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Husu, HL
   Leppäniemi, AK
   Mentula, PJ
AF Husu, Henrik Leonard
   Leppaniemi, Ari Kalevi
   Mentula, Panu Juhani
TI Who would benefit from open abdomen in severe acute pancreatitis?-a
   matched case-control study
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Abdominal compartment syndrome; Abdominal vac; Acute pancreatitis;
   Circulatory failure; Intra-abdominal hypertension; ICU; Laparostomy;
   Multiple organ failure; Necrotizing pancreatitis; Negative-pressure
   wound therapy; NPWT; Open abdomen; Organ failure; Renal failure; Severe
   acute pancreatitis; VAWCM; Vacuum-assisted wound closure; Mesh-mediated
   fascial traction
ID ABDOMINAL COMPARTMENT SYNDROME; PRESSURE WOUND THERAPY; INTRAABDOMINAL
   HYPERTENSION; DECOMPRESSIVE LAPAROTOMY; ISCHEMIA; GUIDELINES; MORTALITY;
   CLOSURE
AB Background Selection of patients for open abdomen (OA) treatment in severe acute pancreatitis (SAP) is challenging. Treatment related morbidity and risk of adverse events are high; however, refractory abdominal compartment syndrome (ACS) is potentially lethal. Factors influencing the decision to initiate OA treatment are clinically important. We aimed to study these factors to help understand what influences the selection of patients for OA treatment in SAP. Methods A single center study of patients with SAP that underwent OA treatment compared with conservatively treated matched controls. Results Within study period, 47 patients treated with OA were matched in a 1:1 fashion with conservatively treated control patients. Urinary output under 20 ml/h (OR 5.0 95% CI 1.8-13.7) and ACS (OR 4.6 95% CI 1.4-15.2) independently associated with OA treatment. Patients with OA treatment had significantly more often visceral ischemia (34%) than controls (6%), P = 0.002. Mortality among patients with visceral ischemia was 63%. Clinically meaningful parameters predicting developing ischemia were not found. OA treatment associated with higher overall 90-day mortality rate (43% vs 17%, P = 0.012) and increased need for necrosectomy (55% vs 21%, P = 0.001). Delayed primary fascial closure was achieved in 33 (97%) patients that survived past OA treatment. Conclusion Decreased urine output and ACS were independently associated with the choice of OA treatment in patients with SAP. Underlying visceral ischemia was strikingly common in patients undergoing OA treatment, but predicting ischemia in these patients seems difficult.
C1 [Husu, Henrik Leonard; Leppaniemi, Ari Kalevi; Mentula, Panu Juhani] Univ Helsinki, Dept Gastrointestinal Surg, POB 340, FI-00029 Helsinki, Finland.
   [Husu, Henrik Leonard; Leppaniemi, Ari Kalevi; Mentula, Panu Juhani] Helsinki Univ Hosp, POB 340, FI-00029 Helsinki, Finland.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital
RP Husu, HL (通讯作者)，Univ Helsinki, Dept Gastrointestinal Surg, POB 340, FI-00029 Helsinki, Finland.
EM henrik.husu@hus.fi
RI Leppäniemi, Ari/GQZ-7991-2022; Mentula, Panu/H-9025-2019
OI Husu, Henrik/0000-0002-7024-8373; Mentula, Panu/0000-0002-6516-3797
FU governmental competitive funds for medical research; Medical Society of
   Finland; Perklens Foundation; Helsinki University Library
FX This study was supported by governmental competitive funds for medical
   research, a research grant from The Medical Society of Finland, and a
   research grant from Perklens Foundation. Open access funded by Helsinki
   University Library.
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NR 21
TC 7
Z9 12
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JUN 10
PY 2021
VL 16
IS 1
AR 32
DI 10.1186/s13017-021-00376-x
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA SV4NH
UT WOS:000663797200004
PM 34112205
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Gigliotti, MJ
   Patel, N
   McLaughlin, C
   Rothermel, A
   Henry, C
   Rizk, E
AF Gigliotti, Michael J.
   Patel, Neel
   McLaughlin, Caroline
   Rothermel, Alexis
   Henry, Cathy
   Rizk, Elias
TI Osteoradionecrosis and microvascular free flap failure managed with
   negative pressure wound therapy: A case report
SO BRITISH JOURNAL OF NEUROSURGERY
LA English
DT Article
DE Osteoradionecrosis; negative pressure wound therapy; microvascular free
   flap; cranial
ID VACUUM-ASSISTED CLOSURE; TEMPORAL BONE; MANDIBULAR OSTEORADIONECROSIS;
   RECONSTRUCTION; RADIATION; OUTCOMES; SCALP; SKULL; HEAD
AB A 56-year-old female with a history of meningioma status post subtotal resection (Simpson grade IV) and extensive radiation therapy presented with osteoradionecrosis (O.R.N.) managed previously with a microvascular free flap (MVFF). The evaluation revealed worsening O.R.N. and a scalp defect of 15 x 10 cm. The patient underwent MVFF reconstruction utilizing a free latissimus muscle flap covered by meshed split-thickness skin graft (STSG). Her surgery was complicated by delayed free flap failure and Serratia marcescens growth, which occurred sometime after discharge from the hospital. This was managed with removal of the free muscle flap and skin graft, serial debridement's, antibiotics, and replacements of a synthetic dural matrix and negative pressure wound therapy (NPWT). Once a clean wound bed was again obtained, the patient underwent fasciocutaneous anterolateral thigh (A.L.T.) MVFF reconstruction, which was complicated by left hypoglossal nerve injury, dehiscence of the flap inset, and dehiscence of the neck access incision requiring revision surgery. On the last follow-up 2 weeks after her surgery, the patient had 100% flap viability and a 2 x 1.5 cm on the left parietal aspect of the flap healing be secondary intent. We demonstrate that NPWT is successful in managing open calvarial wounds due to O.R.N.
C1 [Gigliotti, Michael J.; Patel, Neel; Rizk, Elias] Penn State Hlth Milton S Hershey Med Ctr, Dept Neurosurg, 500 Univ Dr, Hershey, PA 17033 USA.
   [McLaughlin, Caroline; Rothermel, Alexis; Henry, Cathy] Penn State Hlth Milton S Hershey Med Ctr, Dept Plast Surg, 500 Univ Dr, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Gigliotti, MJ (通讯作者)，Penn State Hlth Milton S Hershey Med Ctr, Dept Neurosurg, 500 Univ Dr, Hershey, PA 17033 USA.
EM mgigliotti19505@gmail.com
RI ; Rizk, Elias/NEU-1860-2025
OI Gigliotti, Michael/0000-0001-8183-5832; 
CR Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Bettoni J, 2019, INT J ORAL MAX SURG, V48, P1398, DOI 10.1016/j.ijom.2019.06.007
   Bi HD, 2018, J RECONSTR MICROSURG, V34, P200, DOI 10.1055/s-0037-1608621
   Coskunfirat OK, 2005, PLAST RECONSTR SURG, V115, P54, DOI 10.1097/01.PRS.0000145637.61941.94
   DeMonte F, 2020, OPER NEUROSURG, V0, P1
   Desai SC, 2015, JAMA FACIAL PLAST SU, V17, P56, DOI 10.1001/jamafacial.2014.889
   Goodsell K, 2020, WORLD NEUROSURG, V138, P381, DOI 10.1016/j.wneu.2020.02.140
   Hirsch DL, 2008, J ORAL MAXIL SURG, V66, P2545, DOI 10.1016/j.joms.2007.08.041
   Kadakia S, 2017, AM J OTOLARYNG, V38, P688, DOI 10.1016/j.amjoto.2017.07.005
   Kammeijer Q, 2015, OTOLARYNG HEAD NECK, V152, P718, DOI 10.1177/0194599814564536
   Lee M, 2015, J CRANIO MAXILL SURG, V43, P2026, DOI 10.1016/j.jcms.2015.03.006
   Lim AAT, 1999, AM J OTOLARYNG, V20, P408
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   MARX RE, 1983, J ORAL MAXIL SURG, V41, P283, DOI 10.1016/0278-2391(83)90294-X
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NR 22
TC 7
Z9 9
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0268-8697
EI 1360-046X
J9 BRIT J NEUROSURG
JI Br. J. Neurosurg.
PD NOV 2
PY 2023
VL 37
IS 6
BP 1938
EP 1943
DI 10.1080/02688697.2021.1940845
EA JUN 2021
PG 6
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA HC0R6
UT WOS:000664179800001
PM 34148435
DA 2026-07-24
ER
PT J
AU Bertges, DJ
   Smith, L
   Scully, RE
   Wyers, M
   Eldrup-Jorgensen, J
   Suckow, B
   Ozaki, CK
   Nguyen, L
AF Bertges, Daniel J.
   Smith, Lisa
   Scully, Rebecca E.
   Wyers, Mark
   Eldrup-Jorgensen, Jens
   Suckow, Bjoern
   Ozaki, C. Keith
   Nguyen, Louis
CA PREVENA Trial Investigators
TI A multicenter, prospective randomized trial of negative pressure wound
   therapy for infrainguinal revascularization with a groin incision
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 47th Annual Meeting of the New-England-Society-for-Vascular-Surgery
CY SEP 11-13, 2020
CL ELECTR NETWORK
SP New England Soc Vasc Surg
DE Groin wound; Infrainguinal revascularization; Negative pressure wound
   therapy; PREVENA; Surgical site infection
ID SURGICAL SITE INFECTION; LOWER-EXTREMITY BYPASS; AMERICAN-COLLEGE;
   COMPLICATIONS; SOCIETY; GUIDELINES; MANAGEMENT; SURGEONS; IMPACT
AB Background: Wound complications after open infrainguinal revascularization are a frequent cause of patient morbidity, resulting in increased healthcare costs. The purpose of the present study was to assess the effects of closed incision negative pressure therapy (ciNPT) on groin wound complications after infrainguinal bypass and femoral endarterectomy.
   Methods: A total of 242 patients who had undergone infrainguinal bypass (n = 124) or femoral endarterectomy (n = 118) at five academic medical centers in New England from April 2015 to August 2019 were randomized to ciNPT (PREVENA; 3M KCI, St Paul, Minn; n = 118) or standard gauze (n = 124). The primary outcomemeasure was a composite endpoint of groin wound complications, including surgical site infections (SSIs), major noninfectious wound complications, or graft infections within 30 days after surgery. The secondary outcome measures included 30-day SSIs, 30-day noninfectious wound complications, readmission for wound complications, significant adverse events, and health-related quality of life using the EuroQoL 5D-3L survey.
   Results: The ciNPT and control groups had similar demographics (age, 67 vs 67 years, P = .98; male gender, 71% vs 70%, P = .86; white race, 93% vs 93%, P = .97), comorbidities (previous or current smoking, 93% vs 94%, P = .46; diabetes, 41% vs 48%, P = .20; renal insufficiency, 4% vs 7%, P = .31), and operative characteristics, including procedure type, autogenous conduit, and operative time. No differences were found in the primary composite outcome at 30 days between the two groups (ciNPT vs control: 31% vs 28%; P = .55). The incidence of SSI at 30 days was similar between the two groups (ciNPT vs control: 11% vs 12%; P = .58). Infectious (13.9% vs 12.6%; P = .77) and noninfectious (20.9% vs 17.6%; P = .53) wound complications at 30 days were also similar for the ciNPT and control groups. Wound complications requiring readmission also similar between the two groups (ciNPT vs control: 9% vs 7%; P = .54). The significant adverse event rates were not different between the two groups (ciNPT vs control: 13% vs 16%; P = .53). The mean length of the initial hospitalization was the same for the ciNPT and control groups (5.2 vs 5.7 days; P = .63). The overall health-related quality of life was similar at baseline and at 14 and 30 days postoperatively for the two groups. Although not powered for stratification, we found no differences among the subgroups in gender, obesity, diabetes, smoking, claudication, chronic limb threatening ischemia, bypass, or endarterectomy. On multivariable analysis, no differences were found in wound complications at 30 days for the ciNPT vs gauze groups (odds ratio, 1.4; 95% confidence interval, 0.8-2.6; P = .234).
   Conclusions: In contrast to other randomized studies, our multicenter trial of infrainguinal revascularization found no differences in the 30-day groin wound complications for patients treated with ciNPT vs standard gauze dressings. However, the SSI rate was lower in the control group than reported in other studies, suggesting other practice patterns and processes of care might have reduced the rate of groin infections. Further study might identify the subsets of highrisk patients that could benefit from ciNPT.
C1 [Bertges, Daniel J.] Univ Vermont, Div Vasc Surg, Med Ctr, 111 Colchester Ave,Smith 338, Burlington, VT 05401 USA.
   [Smith, Lisa] Univ Vermont, Off Clin Trials Res, Coll Med, Burlington, VT 05401 USA.
   [Scully, Rebecca E.; Ozaki, C. Keith; Nguyen, Louis] Brigham & Womens Hosp, Div Vasc & Endovasc Surg, Boston, MA USA.
   [Wyers, Mark] Beth Israel Deaconess Med Ctr, Div Vasc Surg, Boston, MA USA.
   [Eldrup-Jorgensen, Jens] Maine Med Ctr, Div Vasc Surg, Portland, ME USA.
   [Suckow, Bjoern] Dartmouth Hitchcock Med Ctr, Sect Vasc Surg, Lebanon, NH USA.
C3 University of Vermont; University of Vermont Medical Center; University
   of Vermont; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard University; Harvard University
   Medical Affiliates; Beth Israel Deaconess Medical Center; Maine Medical
   Center; Dartmouth College
RP Bertges, DJ (通讯作者)，Univ Vermont, Div Vasc Surg, Med Ctr, 111 Colchester Ave,Smith 338, Burlington, VT 05401 USA.
EM daniel.bertges@uvmhealth.org
RI Ozaki, C/A-4937-2013; Scully, Rebecca/AEK-5018-2022
OI Scully, Rebecca/0000-0002-6887-9600
FU Acelity KCI (San Antonio, Tex)
FX The present investigator-initiated study was funded by Acelity KCI (San
   Antonio, Tex).
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   EQ-5D, EQ 5D
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NR 35
TC 24
Z9 27
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD JUL
PY 2021
VL 74
IS 1
BP 257
EP +
DI 10.1016/j.jvs.2020.12.100
EA JUN 2021
PG 12
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA SW1OZ
UT WOS:000664291100033
PM 33548422
OA Bronze
DA 2026-07-24
ER
PT J
AU Buzhardt, S
   Chapple, AG
   LeMoine, F
   McCune, K
   Sutton, EF
AF Buzhardt, Sarah
   Chapple, Andrew G.
   LeMoine, Felicia
   McCune, Kelly
   Sutton, Elizabeth F.
TI Surgical site infection risk in cesarean delivery patients with obesity
   after negative pressure wound therapy: A retrospective cohort study
SO SURGERY
LA English
DT Article
ID COMPLICATIONS; WOMEN; POPULATION; PREVENTION; PREGNANCY; OUTCOMES;
   SECTION; SYSTEM; TRIAL
AB Background: There are conflicting reports of postoperative efficacy of negative pressure wound therapy in patients with obesity after cesarean delivery. Methods: Retrospective cohort study for patients with obesity and negative pressure wound therapy or abdominal dressing after cesarean delivery between April 1, 2014 and January 31, 2018. Postoperative surgical site infection was defined from medical record charting or positive wound culture and confirmed by the hospital's Infection Prevention team. Multivariable logistic regression model for surgical site infection was conducted including additional potential confounding variables. Mantel-Haenszel tests were conducted to stratify by body mass index class and operative time, and we performed quasi-Poisson regression to determine which factors were associated with an increased operative time. Results: We included 4,391 Black or White patients with obesity, 696 (15.9%) underwent negative pressure wound therapy and 3,695 (84.1%) abdominal dressing after cesarean delivery. Incidence of surgical site infection after negative pressure wound therapy and abdominal dressing were 6.1% and 3.4%, respectively (2-sample test of proportions P < .001). The multivariable logistic regression (covariates: race, diabetes, body mass index category, insurance, scheduled/emergency, artificial rupture, previous c-section, operative time, age, closure type) found negative pressure wound therapy dressing was associated with an increased risk of surgical site infection (adjusted odds ratio 1.54; 95% confidence interval, 1.01-2.34), as did a Mantel-Haenszel test which was stratified by body mass index (odds ratio 1.62; 95% confidence interval, 1.08-2.43) and a Mantel-Haenszel test stratified by operative time (odds ratio 1.85; 95% confidence interval, 1.28-2.65). Negative pressure wound therapy dressing also led to an increase in operative time in the Quasi-Poisson regression, which was the primary predictor of infection. Conclusion: Negative pressure wound therapy was associated with an increased the risk of postoperative surgical site infection after cesarean delivery in our obstetric patients with obesity. Future prospective studies are needed to determine a dressing type and other intervention to decrease postoperative cesarean surgical site infection in women with obesity. (c) 2021 Elsevier Inc. All rights reserved.
C1 [Buzhardt, Sarah; LeMoine, Felicia; McCune, Kelly] Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, Baton Rouge, LA 70803 USA.
   [Chapple, Andrew G.] Louisiana State Univ, Sch Publ Hlth, Biostat Program, Hlth Sci Ctr, New Orleans, LA 70803 USA.
   [Sutton, Elizabeth F.] Womans Hosp, Womans Hosp Res Ctr, 100 Womans Way, Baton Rouge, LA 70817 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport; Louisiana State University; Louisiana
   State University System; Louisiana State University Health Sciences
   Center New Orleans
RP Sutton, EF (通讯作者)，Womans Hosp, Womans Hosp Res Ctr, 100 Womans Way, Baton Rouge, LA 70817 USA.
EM Elizabeth.Sutton@womans.org
FU Louisiana State University Health Sciences Center; Obstetrics and
   Gynecology Residency Research Program; Woman's Hospital Research Center
   of Woman's Hospital, Baton Rouge, Louisiana
FX This research study was supported generously by donated time and effort
   by the Louisiana State University Health Sciences Center, Obstetrics and
   Gynecology Residency Research Program and Woman's Hospital Research
   Center of Woman's Hospital, Baton Rouge, Louisiana.
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NR 31
TC 3
Z9 5
U1 0
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
EI 1532-7361
J9 SURGERY
JI Surgery
PD JUL
PY 2021
VL 170
IS 1
BP 153
EP 159
DI 10.1016/j.surg.2021.02.056
EA JUN 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TA5OR
UT WOS:000667298800025
PM 33838882
DA 2026-07-24
ER
PT J
AU Jacob-Brassard, J
   Al-Omran, M
   Salata, K
   Hussain, MA
   Kayssi, A
   Roche-Nagle, G
   de Mestral, C
AF Jacob-Brassard, Jean
   Al-Omran, Mohammed
   Salata, Konrad
   Hussain, Mohamad A.
   Kayssi, Ahmed
   Roche-Nagle, Graham
   de Mestral, Charles
TI A survey of Canadian surgeons on the indications for home care nursing
   following vascular surgery
SO CANADIAN JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT 19th Annual Congress of the SSVq
CY NOV 21, 2019
CL Quebec, CANADA
SP SSVq
ID HEALTH-CARE; REPAIR; EUROPE
AB Background Recent evidence suggests that home care nursing is variably prescribed after vascular surgery, and may reduce emergency department visits and hospital readmissions. We therefore sought to characterize the indications for home care nursing following vascular surgery from the surgeon's perspective. Methods An online survey was distributed to the 141 members of the Canadian Society for Vascular Surgery with questions related to home care nursing after carotid endarterectomy (CEA), endovascular aortic aneurysm repair (EVAR), open abdominal aortic aneurysm (AAA) repair and open or hybrid revascularization for peripheral arterial disease (PAD). We included all questionnaires in our analysis; the frequency denominator changes according to the number of respondents who completed each survey item. Results There were 46 survey respondents (33% of 141) from across the country. A total of 28 (62% of 45) worked in a teaching hospital. Home care nursing was routinely prescribed by 5%, 10%, 31% and 41% of respondents following CEA, EVAR, open AAA repair and open or hybrid revascularization for PAD, respectively. Across all procedure types, the same procedure-related criteria were most often deemed to warrant a prescription for home care nursing: surgical site infection, wound complications (e.g., open wound, lymphatic leak) and use of negative-pressure wound therapy. Across all procedure types, lack of social support, physical frailty and cognitive impairment were most frequently identified as patient-specific considerations for prescribing home care nursing. Few respondents reported restrictions or standards that informed their prescribing practice. Conclusion Most surgeon respondents agreed on the indications for home care nursing after vascular surgery. However, evidence-based standards to guide patient selection for home care nursing after vascular surgery are needed.
C1 [Jacob-Brassard, Jean; Al-Omran, Mohammed; Salata, Konrad; Hussain, Mohamad A.; Kayssi, Ahmed; Roche-Nagle, Graham] Univ Toronto, Dept Surg, Toronto, ON, Canada.
   [Al-Omran, Mohammed; Salata, Konrad; Hussain, Mohamad A.; de Mestral, Charles] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Kayssi, Ahmed] Sunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON, Canada.
   [Roche-Nagle, Graham] Univ Hlth Network, Peter Munk Cardiac Ctr, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; Saint Michaels Hospital
   Toronto; Li Ka Shing Knowledge Institute; University of Toronto;
   Sunnybrook Health Science Center; Sunnybrook Research Institute;
   University of Toronto; University Health Network Toronto; Peter Munk
   Cardiac Centre
RP de Mestral, C (通讯作者)，St Michaels Hosp, 30 Bond St,Off Bond 7-080, Toronto, ON M5B 1W8, Canada.
EM charles.deMestral@unityhealth.to
RI Hussain, Mohamad/M-7595-2019; Al-Omran, Mohammed/IXX-0542-2023
OI Hussain, Mohamad/0000-0003-2471-8167; 
FU Blair Foundation Vascular Surgery Innovation Fund
FX This work was supported by the Blair Foundation Vascular Surgery
   Innovation Fund, jointly established with the University of Toronto.
CR [Anonymous], 2018, ARR CAR YOU LEAV HOS
   [Anonymous], Home Health Services Coverage
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NR 24
TC 3
Z9 3
U1 0
U2 2
PU CMA-CANADIAN MEDICAL ASSOC
PI OTTAWA
PA 1867 ALTA VISTA DR, OTTAWA, ONTARIO K1G 5W8, CANADA
SN 0008-428X
EI 1488-2310
J9 CAN J SURG
JI Can. J. Surg.
PD APR
PY 2021
VL 64
IS 2
BP E149
EP E154
DI 10.1503/cjs.001220
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA TA5UM
UT WOS:000667314200006
PM 33666391
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, YJ
   Yao, XF
   Lin, YS
   Wang, JY
   Chang, CC
AF Wang, Yen-Jen
   Yao, Xiao-Feng
   Lin, Yang-Sheng
   Wang, Jen-Yu
   Chang, Chang-Cheng
TI Oncologic feasibility for negative pressure wound therapy application in
   surgical wounds: A meta-analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE malignant neoplasms; melanoma; negative-pressure wound therapy;
   recurrence; sarcoma
ID VACUUM-ASSISTED CLOSURE; ACRAL LENTIGINOUS MELANOMA; INGUINAL
   LYMPHADENECTOMY; SITE INFECTION; PENILE CANCER; OPEN ABDOMEN;
   COMPLICATIONS; HYPOXIA; VULVECTOMY; MANAGEMENT
AB Negative pressure wound therapy (NPWT) decreases postoperative complications of various surgeries. However, the use of NPWT for oncological surgical wounds remains controversial. To evaluate the association of NPWT with oncologic recurrence in surgical wounds without residual malignancy, we analysed studies that compared NPWT with conventional non-pressure dressings for cancer surgical wounds without residual tumour by August 12, 2020. We compared tumour recurrence rates and postoperative complications between the two procedures. The six studies included 118 patients who received NPWT, and 149 patients who received conventional non-pressure wound care. The overall quality of the included studies was high based on the Newcastle-Ottawa scale score of 7.5. Tumour recurrence after NPWT was not significantly different compared with conventional non-negative pressure wound care (9.3% versus 11.4%, P = 0.40). There was no significant heterogeneity between the studies (I-2 = 3%). Although NTWT was associated with a lower complication rate compared with the control group, the result was non-significant (P = 0.15). Application of NPWT in oncologic resection wounds without residual malignancy revealed no difference in local recurrence and may reduce the risk of postoperative complications compared with conventional non-negative pressure dressings. NPWT can be considered an alternative method for reconstruction in challenging cases.
C1 [Wang, Yen-Jen; Yao, Xiao-Feng; Wang, Jen-Yu] MacKay Mem Hosp, Dept Dermatol, Taipei, Taiwan.
   [Wang, Yen-Jen] Mackay Jr Coll Med Nursing & Management, Dept Cosmet Applicat & Management, Taipei, Taiwan.
   [Lin, Yang-Sheng] MacKay Med Coll, Dept Med, New Taipei, Taiwan.
   [Lin, Yang-Sheng] MacKay Mem Hosp, Dept Internal Med, Div Gastroenterol, Taipei, Taiwan.
   [Lin, Yang-Sheng] MacKay Mem Hosp, Evidence Based Med Ctr, Taipei, Taiwan.
   [Lin, Yang-Sheng] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan.
   [Chang, Chang-Cheng] China Med Univ, Dept Cosmeceut, Taichung, Taiwan.
   [Chang, Chang-Cheng] Natl Yang Ming Chiao Tung Univ, Inst Imaging & Biomed Photon, Tainan, Taiwan.
   [Chang, Chang-Cheng] China Med Univ Hosp, Aesthet Med Ctr, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
   [Chang, Chang-Cheng] China Med Univ, China Med Univ Hosp, Coll Med, Med, Taichung, Taiwan.
C3 Mackay Memorial Hospital; Mackay Junior College of Medicine, Nursing &
   Management; Mackay Medical University; Mackay Memorial Hospital; Mackay
   Memorial Hospital; Taipei Medical University; China Medical University
   Taiwan; National Yang Ming Chiao Tung University; China Medical
   University Taiwan; China Medical University Hospital - Taiwan; China
   Medical University Taiwan; China Medical University Hospital - Taiwan
RP Chang, CC (通讯作者)，China Med Univ Hosp, Aesthet Med Ctr, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
EM changcc1975@gmail.com
OI Wang, Yen-Jen/0000-0002-0425-9154
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NR 53
TC 14
Z9 17
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR
PY 2022
VL 19
IS 3
BP 573
EP 582
DI 10.1111/iwj.13654
EA JUN 2021
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ZH2HY
UT WOS:000667602500001
PM 34184411
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Khouqeer, A
   Uribe-Gomez, A
   Sharath, SS
   Kougias, P
   Barshes, NR
AF Khouqeer, Ahmed
   Uribe-Gomez, Alexander
   Sharath, Sherene S.
   Kougias, Panos
   Barshes, Neal R.
TI Wound Complications and Reoperations after Transtibial Amputation of the
   Leg
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID RISK-FACTORS; EXTREMITY; SURGERY; MULTICENTER; INFECTIONS; CLOSURE
AB Background: Transtibial amputations (TTAs) of the leg have been associated with high rates of wound complications. We assessed outcomes of TTAs to determine if bundled interventions implemented at our hospital had an impact on lowering wound complications, including surgical site infections.
   Methods: We assessed the impact of a surgical site infection prevention bundle (negative-pressure wound therapy, minimizing the use of staples, and a decontamination protocol for methicillin-resistant Staphylococcus aureus) on 90-day wound complications. The year of implementation of the prevention bundle was excluded, and the pre-eras and posteras were defined as the four-year period before and after implementation. The study sample consisted of a single-center cohort, with TTA cases identified using operating room scheduling software.
   Results: A total of 182 TTAs were performed: 110 in the pre-era and 72 in the postera. The wound complication rate decreased from 22 to 17% despite fewer two-stage operations, less imaging to identify peripheral artery disease, and an increased proportion of patients with end-stage renal disease. Wound complications and revision to a higher level of amputation were more associated with indication (especially no-option peripheral artery disease with ischemic rest pains) than with any particular aspect of surgical technique. The use of drains was associated with reoperations but not higher level revision.
   Conclusions: Higher rates of wound complications and revision to a higher level of amputations should be expected among patients with no-option peripheral artery disease with ischemic rest pains undergoing TTAs. Drains should be avoided.
C1 [Khouqeer, Ahmed; Sharath, Sherene S.; Kougias, Panos; Barshes, Neal R.] Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   [Uribe-Gomez, Alexander; Sharath, Sherene S.; Kougias, Panos; Barshes, Neal R.] Michael E DeBakey VA Med Ctr, Houston, TX USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   Medical Hospital
RP Khouqeer, A (通讯作者)，Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Michael E Debakey Dept Surg, Div Vasc & Endovasc Surg, 2002 Holcombe Blvd,OCL 112, Houston, TX 77030 USA.
EM ahmedfk10@gmail.com
RI Sharath, Sherene/JYP-3673-2024
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NR 20
TC 7
Z9 7
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD NOV
PY 2020
VL 69
BP 292
EP 297
DI 10.1016/j.avsg.2020.05.023
PG 6
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA TB6FL
UT WOS:000668041300036
PM 32474142
DA 2026-07-24
ER
PT J
AU Teot, L
   Ohura, N
AF Teot, Luc
   Ohura, Norihiko
TI Challenges and Management in Wound Care
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FREE TISSUE TRANSFER; V-Y FLAP; ANTISEPTIC
   SOLUTION; DISTAL PERFORATOR; STERNAL WOUNDS; LIMB SALVAGE; MUSCLE FLAP;
   THERAPY; INSTILLATION
AB Wounds have been one of the most prominent pathologies since the beginning of humanity. For the last 5 decades, a drastic improvement of healing has been observed, thanks to new medical devices based on fluid aspiration capacities and the development of negative pressure wound therapy. Negative-pressure wound therapy was initially designed for a double action, fluid aspiration and mechanical stimulation of wound edges by a foam. Successive technical evolutions of negative pressure wound therapy were declined since 1997 when Argenta and Morykwas first presented their solution. The adjunct of instillation in 2009 was considered as the first interactive dressing, allowing topical wound solutions to sequentially reach the wound, in alternance with negative pressure. Other devices based on the same principle were designed to prevent postoperative infections when placed over a suture after surgery. This long evolution could enhance the armamentarium of possible solutions, considerably reducing the wound healing time.
C1 [Teot, Luc; Ohura, Norihiko] Montpellier Univ Hosp, Hop La Colombiere, Dept Plast Surg Wound Healing Burns, Montpellier, France.
   [Teot, Luc; Ohura, Norihiko] Kyorin Univ, Sch Med, Dept Plast Reconstruct & Aesthet Surg, Kyorin, Japan.
C3 Universite de Montpellier; CHU de Montpellier; Kyorin University
RP Teot, L (通讯作者)，Montpellier Univ Hosp, Hop La Colombiere, Dept Plast Surg Wound Healing Burns, Montpellier, France.
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NR 62
TC 38
Z9 43
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 9S
EP 15S
DI 10.1097/PRS.0000000000007628
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500004
PM 33347058
DA 2026-07-24
ER
PT J
AU Faust, E
   Opoku-Agyeman, JL
   Behnam, AB
AF Faust, Elizabeth
   Opoku-Agyeman, Jude L.
   Behnam, Amir B.
TI Use of Negative-Pressure Wound Therapy With Instillation and Dwell Time:
   An Overview
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ANTISEPTIC SOLUTION; MULTICENTER; SALINE; FOAM
AB The use of negative-pressure wound therapy (NPWT) has become an established therapy for wound management. There have been many advancements in the technology of NPWT including NPWT with instillation and dwell (NPWTi-d). NPWTi-d promotes wound healing by wound cleansing, irrigation, and nonexcisional debridement. NPWTi-d has been shown in comparative clinical studies to decrease the time to definitive wound healing and length of hospitalization. NPWTi-d-using a reticulated open-cell foam dressing with "through" holes (ROCF-CC)-has been postulated to facilitate solubilization, detachment, and elimination of infectious materials, such as slough and thick exudate, before or after operative debridement, and in cases where surgical debridement is not an option. The authors provide an overview on the use of NPWTi-d by reviewing the components of the system, proposed mechanism of action, clinical outcomes, and current consensus guidelines for its utilization.
C1 [Faust, Elizabeth; Opoku-Agyeman, Jude L.; Behnam, Amir B.] Tower Hlth Syst, Reading Hosp, Wound Ost Continence Care Nursing Adm, 6th Ave & Spruce St, W Reading, PA 19611 USA.
   [Faust, Elizabeth; Opoku-Agyeman, Jude L.; Behnam, Amir B.] Philadelphia Coll Osteopath Med, Dept Plast Surg, Philadelphia, PA USA.
   [Faust, Elizabeth; Opoku-Agyeman, Jude L.; Behnam, Amir B.] Tower Hlth Syst, Dept Surg, Div Plast Surg, Reading Hosp, W Reading, PA 19611 USA.
C3 Philadelphia College of Osteopathic Medicine
RP Faust, E (通讯作者)，Tower Hlth Syst, Reading Hosp, Wound Ost Continence Care Nursing Adm, 6th Ave & Spruce St, W Reading, PA 19611 USA.
EM elizabeth.faust@towerhealth.org
RI /AAW-6087-2020
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NR 38
TC 31
Z9 34
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 16S
EP 26S
DI 10.1097/PRS.0000000000007607
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500005
PM 33347059
DA 2026-07-24
ER
PT J
AU Kim, PJ
   Attinger, CE
AF Kim, Paul J.
   Attinger, Christopher E.
TI Negative-Pressure Wound Therapy With Instillation: A Tool in the
   Multidisciplinary Approach to Limb Function Preservation
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID ANTISEPTIC SOLUTION; CARE; AMPUTATION; OUTCOMES; FOAM; AMBULATION;
   IMPACT; SALINE
AB The multidisciplinary approach to lower extremity function preservation is well established and is globally considered the standard of care. Every member of the team contributes their unique skills and knowledge to patient care. The effective integration of negative-pressure wound therapy with instillation (NPWTi) has fundamentally changed the approach to the infected or contaminated wound. Initially, in conjunction with excisional debridement, NPWTi has demonstrated its utility of expediting wound bed preparation for closure or coverage. With the introduction of a novel foam design, the effectiveness has increased and provided an option in cases where surgical intervention is not available or recommended. The successful implementation and continued monitoring of NPWTi provides an efficient tool to expedite ultimate wound healing and involves all members of the team.
C1 Univ Texas Southwestern, Dept Plast Surg & Orthoped Surg, Dallas, TX 75390 USA.
   MedStar Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; Georgetown University
RP Kim, PJ (通讯作者)，Univ Texas Southwestern, Dept Plast Surg, Outpatient Bldg,1801 Inwood Rd, Dallas, TX 75390 USA.
EM Paul.Kim@UTSouthwestern.edu
OI , Paul/0000-0002-6186-6890
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NR 45
TC 5
Z9 6
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 27S
EP 33S
DI 10.1097/PRS.0000000000007608
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500006
PM 33347060
DA 2026-07-24
ER
PT J
AU Constantine, T
AF Constantine, Thomas
TI Use of Negative-Pressure Wound Therapy With Instillation and Dwell in
   Breast Reconstruction
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; IMPLANT SALVAGE; IMMEDIATE; COMPLICATIONS;
   SALINE; SURGERY; IMPACT
AB The use of negative-pressure wound therapy (NPWT) has expanded over the last 3 decades, paralleled and documented by an increase in research. This article discusses the evolution and current applications of NPWT in modern breast reconstruction. Negative-pressure wound therapy with instillation and dwell (NPWTi-d) technology can be used to remove infectious material, facilitate salvaging compromised tissue, and stabilize the soft-tissue environment. Published consensus NPWTi-d guidelines can aid in treatment selection and implementation of this new technology. The therapeutic approach of simultaneously removing infectious material and actively improving mastectomy flap perfusion and thickness is a burgeoning concept, and illustrative cases are presented. NPWTi-d preliminary use has led to reconstruction salvage with reproducible early experience and outcomes, and it is hoped that it will raise interest and awareness of this promising application of the technology to improve breast reconstruction outcomes.
C1 [Constantine, Thomas] Humber River Hosp, Div Plast Surg, 1235 Wilson Ave, Toronto, ON, Canada.
RP Constantine, T (通讯作者)，Humber River Hosp, Div Plast Surg, 1235 Wilson Ave, Toronto, ON, Canada.
EM thomas.constantine.md@gmail.com
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   Pusic AL, 2009, PLAST RECONSTR SURG, V124, P345, DOI 10.1097/PRS.0b013e3181aee807
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   Sforza M, 2014, AESTHET SURG J, V34, P1172, DOI 10.1177/1090820X14545985
   Sforza M, 2011, PLAST RECONSTR SURG, V128, p33E, DOI 10.1097/PRS.0b013e3182173fd3
   Singh D, 2017, Plastic & Reconstructive Surgery Global Open, V5, P57, DOI 10.1097/01.gox.0000526243.49604.da
   Sullivan SR, 2008, PLAST RECONSTR SURG, V122, P19, DOI 10.1097/PRS.0b013e3181774267
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NR 33
TC 3
Z9 5
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 34S
EP 42S
DI 10.1097/PRS.0000000000007612
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500007
PM 33347061
DA 2026-07-24
ER
PT J
AU Diehm, YF
   Fischer, S
   Wirth, GA
   Haug, V
   Orgill, DP
   Momeni, A
   Horch, RE
   Lehner, B
   Kneser, U
   Hirche, C
AF Diehm, Yannick F.
   Fischer, Sebastian
   Wirth, Garrett A.
   Haug, Valentin
   Orgill, Dennis P.
   Momeni, Arash
   Horch, Raymund E.
   Lehner, Burkhard
   Kneser, Ulrich
   Hirche, Christoph
TI Management of Acute and Traumatic Wounds With Negative-Pressure Wound
   Therapy With Instillation and Dwell Time
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID MICROSURGICAL RECONSTRUCTION; ANTISEPTIC SOLUTION; SALINE; DEFECTS;
   IMPACT; LEVEL; FOAM; LEG
AB Background: A promising and useful development of negative-pressure wound therapy (NPWT) is the addition of instillation and dwell time of topical wound solutions (NPWTi-d). Uses of NPWTi-d include acute and traumatic wounds, whereby wound closure may be facilitated via wound cleansing and promotion of granulation tissue formation. This systematic review summarizes publications on NPWTi-d in the treatment of acute and traumatic wounds.
   Methods: A systematic review was performed analyzing articles from major clinical databases. Only clinical studies >= 10 patients reporting on the application of NPWTi-d in acute and traumatic wounds were included.
   Results: One hundred ninety-two articles were retrieved, of which 10 articles met inclusion criteria. Of those, 2 were lesser-quality randomized controlled trials, comparative studies or prospective cohorts, 2 were retrospective studies, and 6 retrospective cohort studies. In total, included publications reported 109 patients with acute and traumatic wounds treated with NPWTi-d. Data from these studies indicated the potential for reduction in bacterial bioburden through wound cleansing and promotion of granulation tissue formation, thereby facilitating wound closure, reduced length of therapy and hospital time. However, for most publications, different wound causes and subsequently no isolated results for acute and traumatic wounds were reported.
   Conclusion: NPWTi-d has promise to be effective in facilitating wound closure and reducing the time for wound closure. The present systematic review demonstrates a relatively low level of evidence available to objectively support this effect. To underline these positive results, large prospective, randomized controlled trials are necessary to manifest the role of NPWTi-d in the daily clinical routine for this wound category.
C1 [Diehm, Yannick F.; Fischer, Sebastian; Wirth, Garrett A.; Haug, Valentin; Orgill, Dennis P.; Momeni, Arash; Horch, Raymund E.; Lehner, Burkhard; Kneser, Ulrich; Hirche, Christoph] Heidelberg Univ, Dept Hand Plast & Reconstruct Surg, Microsurg, Burn Trauma Ctr,BG Trauma Ctr Ludwigshafen, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
   [Diehm, Yannick F.; Fischer, Sebastian; Wirth, Garrett A.; Haug, Valentin; Orgill, Dennis P.; Momeni, Arash; Horch, Raymund E.; Lehner, Burkhard; Kneser, Ulrich; Hirche, Christoph] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA 02115 USA.
   [Diehm, Yannick F.; Fischer, Sebastian; Wirth, Garrett A.; Haug, Valentin; Orgill, Dennis P.; Momeni, Arash; Horch, Raymund E.; Lehner, Burkhard; Kneser, Ulrich; Hirche, Christoph] Wirth Plast Surg, Newport Beach, CA USA.
   [Diehm, Yannick F.; Fischer, Sebastian; Wirth, Garrett A.; Haug, Valentin; Orgill, Dennis P.; Momeni, Arash; Horch, Raymund E.; Lehner, Burkhard; Kneser, Ulrich; Hirche, Christoph] Stanford Univ, Sch Med, Div Plast & Reconstruct Surg, Hagey Lab Pediat Regenerat Med, Palo Alto, CA 94304 USA.
   [Diehm, Yannick F.; Fischer, Sebastian; Wirth, Garrett A.; Haug, Valentin; Orgill, Dennis P.; Momeni, Arash; Horch, Raymund E.; Lehner, Burkhard; Kneser, Ulrich; Hirche, Christoph] Friedrich Alexander Univ, Univ Hosp Erlangen, Dept Plast & Hand Surg, Erlangen, Germany.
   [Diehm, Yannick F.; Fischer, Sebastian; Wirth, Garrett A.; Haug, Valentin; Orgill, Dennis P.; Momeni, Arash; Horch, Raymund E.; Lehner, Burkhard; Kneser, Ulrich; Hirche, Christoph] Friedrich Alexander Univ, Univ Hosp Erlangen, Lab Tissue Engn & Regenerat Med, Erlangen, Germany.
   [Diehm, Yannick F.; Fischer, Sebastian; Wirth, Garrett A.; Haug, Valentin; Orgill, Dennis P.; Momeni, Arash; Horch, Raymund E.; Lehner, Burkhard; Kneser, Ulrich; Hirche, Christoph] Orthoped Univ Hosp, Dept Orthoped Oncol & Sept Orthoped Surg, Ludwigshafen, Germany.
C3 Ruprecht Karls University Heidelberg; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Stanford University; University of Erlangen Nuremberg;
   University of Erlangen Nuremberg
RP Hirche, C (通讯作者)，Heidelberg Univ, Dept Hand Plast & Reconstruct Surg, Microsurg, Burn Trauma Ctr,BG Trauma Ctr Ludwigshafen, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
EM Christoph.Hirche@bgu-ludwigshafen.de
RI Momeni, Arash/AAV-8300-2020; Orgill, Dennis/H-7596-2019; Fischer,
   Sebastian/AEX-5429-2022; Horch, Raymund/H-8128-2019
OI Momeni, Arash/0000-0002-6452-751X; 
CR Blalock L, 2019, WOUNDS, V31, P55
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   Gabriel A., 2014, Eplasty, V14
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NR 32
TC 25
Z9 29
U1 2
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 43S
EP 53S
DI 10.1097/PRS.0000000000007610
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500008
PM 33347062
DA 2026-07-24
ER
PT J
AU Liu, J
   Crist, BD
AF Liu, Jane
   Crist, Brett D.
TI Management of Wounds With Orthopedic Fixation Hardware Using
   Negative-Pressure Wound Therapy With Instillation and Dwell
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SALINE INSTILLATION; INFECTIONS; HIP;
   FRACTURES; SURGERY; SYSTEM; IMPACT
AB Negative-pressure wound therapy with instillation and dwell (NPWTi-d) is an option for management of wounds with exposed orthopedic fixation hardware. The mechanical effect of the negative-pressure therapy works to contract the wound edges, and the instillation of solution and its subsequent removal help remove infectious material. NPWTi-d also promotes robust granulation tissue formation. In this article, we discuss the science behind NPWTi-d and its role in the treatment of wounds with indwelling orthopedic fixation hardware.
C1 [Liu, Jane; Crist, Brett D.] Univ Missouri, Dept Orthopaed Surg, One Hosp Dr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia
RP Crist, BD (通讯作者)，Univ Missouri, Dept Orthopaed Surg, One Hosp Dr, Columbia, MO 65212 USA.
EM cristb@health.missouri.edu
RI Crist, Brett/AAC-7535-2019
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NR 50
TC 3
Z9 3
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 54S
EP 60S
DI 10.1097/PRS.0000000000007622
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500009
PM 33347063
DA 2026-07-24
ER
PT J
AU Arowojolu, OA
   Wirth, GA
AF Arowojolu, Omotayo A.
   Wirth, Garrett A.
TI Sacral and Ischial Pressure Ulcer Management With Negative-Pressure
   Wound Therapy With Instillation and Dwell
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COMPLEX WOUNDS; BRADEN SCALE; SCIENCE; SYSTEM;
   SALINE; RISK
AB Background: The addition of topical fluid instillation, a programmable "dwell" time and a novel foam-wound interface to the established wound healing benefits of negative-pressure wound therapy (NPWT) works synergistically to benefit patients with complex wounds. This engineering breakthrough for wound care has been termed NPWT with instillation and dwell (NPWTi-d), and the new foam dressings are reticulated open cell foam dressings specifically designed for use with NPWTi-d. This combined technology has shown promise in chronic, complex wounds and has potential for the management of sacral and ischial pressure wounds.
   Methods: A qualitative comprehensive review was performed analyzing articles from PubMed and Medline that reported on the use of NPWTi-d in sacral or ischial pressure ulcers. Case series and case reports were predominant, and results of cases specific to sacral and ischial pressure wounds were extracted from larger studies and summarized for presentation.
   Results: Compared with conventional NPWT alone, NPWTi-d has been shown to help irrigate the wound, remove fibrinous debris, and promote granulation tissue formation. This is associated with a decreased number of operative debridements and decreased hospital length of stay.
   Conclusions: This technology is rapidly demonstrating expanded utilization in hospitalized patients with chronic sacral and ischial pressure ulcers. When used correctly, NPWTi-d serves as an effective "bridge to defined endpoint": whether that is a flap reconstruction, skin grafting, or discharge home with a stable chronic wound and simplified wound care.
C1 [Arowojolu, Omotayo A.] Univ Calif Irvine, Med Ctr, Dept Plast Surg, Irvine, CA USA.
   [Wirth, Garrett A.] Wirth Plast Surg, 1401 Avocado Ave,Suite 810, Newport Beach, CA 92660 USA.
C3 University of California System; University of California Irvine
RP Wirth, GA (通讯作者)，Wirth Plast Surg, 1401 Avocado Ave,Suite 810, Newport Beach, CA 92660 USA.
EM drwirth@wirthplasticsurgery.com
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NR 41
TC 17
Z9 19
U1 3
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 61S
EP 67S
DI 10.1097/PRS.0000000000007613
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500010
PM 33347064
DA 2026-07-24
ER
PT J
AU Gabriel, A
   Camardo, M
   O'Rorke, E
   Gold, R
   Kim, PJ
AF Gabriel, Allen
   Camardo, Mark
   O'Rorke, Erin
   Gold, Rebecca
   Kim, Paul J.
TI Effects of Negative-Pressure Wound Therapy With Instillation versus
   Standard of Care in Multiple Wound Types: Systematic Literature Review
   and Meta-Analysis
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Review
ID ANTISEPTIC SOLUTION; SALINE
AB Background: Large randomized controlled trials that evaluate the effects of negative-pressure wound therapy with instillation of a topical solution and dwell time (NPWTi-d) are lacking. There is a need to synthesize existing data across multiple studies to provide a more precise estimate of the clinical effects of NPWTi-d.
   Methods: A systematic literature review and a meta-analysis of comparative studies were performed to determine the effects of NPWTi-d versus control therapy in the adjunctive management of complex wounds. Weighted standardized mean difference or odds ratios and 95% confidence intervals were calculated to pool study and control group results in each publication for analysis.
   Results: Thirteen studies comprising 720 patients were included in the analysis. Significantly fewer surgical debridements were performed in NPWTi-d patients versus control patients (P = 0.01). Wounds in the NPWTi-d group were ready for closure faster than control wounds (P = 0.03). The odds of reducing bacterial count from baseline in the NPWTi-d group was 4.4 times greater than control group wounds (P = 0.003), and percent reduction of bacterial count in NPWTi-d wounds was evident in all studies that captured that endpoint. There was a significantly shorter length of therapy in NPWTi-d patients versus control patients (P = 0.03). Wounds in NPWTi-d group were 2.39 times more likely to close than control group wounds (P = 0.01). Length of hospital stay was not significantly reduced for NPWTi-d patients compared with that for control patients (P = 0.06).
   Conclusion: Results of this meta-analysis show a positive effect with use of NPWTi-d in various wound types.
C1 Loma Linda Univ, Dept Plast Surg, Loma Linda, CA 92350 USA.
   3M, San Antonio, TX USA.
   Washington State Univ, Washington, DC USA.
   Washington State Univ, Elson S Floyd Coll Med, Washington, DC USA.
   Univ Texas Southwestern Med Ctr Dallas, Dallas, TX USA.
C3 Loma Linda University; 3M; Washington State University; Washington State
   University; University of Texas System; University of Texas Southwestern
   Medical Center
RP Gabriel, A (通讯作者)，505 NE 87th Avene,Suite 250, Vancouver, WA 98664 USA.
EM gabrielallen@yahoo.com
RI ; Gabriel, Allen/AFK-3548-2022
OI , Paul/0000-0002-6186-6890; 
CR Chowdhry SA, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002087
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NR 28
TC 35
Z9 41
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 68S
EP 76S
DI 10.1097/PRS.0000000000007614
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500011
PM 33347065
DA 2026-07-24
ER
PT J
AU Tank, JC
   Georgiadis, GM
   Bair, JM
   Rice, A
   O'Mara Gardner, K
   Chen, JT
   Redfern, RE
AF Tank, Jason C.
   Georgiadis, Gregory M.
   Bair, Jeffrey M.
   Rice, Alexi
   O'Mara Gardner, Kristin
   Chen, John T.
   Redfern, Roberta E.
TI Does The Use of Ethyl Chloride Improve Patient-Reported Pain Scores With
   Negative Pressure Wound Therapy Dressing Changes? A Prospective,
   Randomized Controlled Trial
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Ethyl chloride; negative pressure wound therapy; pain; dressing change;
   vapocoolant
ID VAPOCOOLANT SPRAY; LIDOCAINE; REDUCE; CREAM
AB Background Negative pressure wound therapy (NPWT) is commonly used for surgical incisions and large wounds, particularly in the context of trauma. Research has shown that patients report that the most painful aspect of NPWT is related to foam dressing changes. This study aimed to determine whether topical use of the vapocoolant anesthetic ethyl chloride would impact patient-reported pain during these procedures. Methods This study was a single-blinded, placebo-controlled randomized trial in patients who were undergoing NPWT foam dressing change following surgery performed by the orthopedic trauma team. A total of 100 patients were randomized to receive ethyl chloride topical anesthetic spray or placebo (tissue culture grade water) during dressing change. The outcome measure specified prior to enrollment was a mean decrease in patient-reported pain of 1.7 points using a numeric rating scale. Baseline and procedural characteristics were collected to investigate contributions to patient-reported pain. We hypothesized that the use of ethyl chloride would decrease patient reported pain scores. Results Significantly more females were randomized to the receive vapocoolant; remaining baseline and procedural characteristics were similar between groups. The median time for NPWT drape removal was 2.0 minutes in both groups (p = 0.66). The postprocedural pain reported by patients was significantly lower in the experimental group compared with placebo (median, 5.0 vs. 7.0; p = 0.03). Multivariate analysis adjusting for potential confounders showed treatment group to be the strongest predictor of postprocedure pain (p = 0.002). Additionally, a generalized linear model suggests that treatment group was the strongest predictor of change in pain score as reported by patients prior to and immediately following dressing change. Conclusions Use of vapocoolant spray during NPWT dressing change for orthopedic trauma wounds and surgical incisions was feasible and resulted in significant reduction in patient-reported pain associated with the procedure. LEVEL OF EVIDENCE Therapeutic, Level I
C1 [Tank, Jason C.; Georgiadis, Gregory M.; Bair, Jeffrey M.] ProMed Toledo Hosp, Dept Orthopaed Surg, Sect Orthopaed Trauma, Toledo, OH USA.
   [Rice, Alexi] ProMed Toledo Hosp, Enterostomal Therapy, Toledo, OH USA.
   [O'Mara Gardner, Kristin] ProMed Toledo Hosp, Dept Orthopaed, Toledo, OH USA.
   [Chen, John T.] Bowling Green State Univ, Dept Math & Stat, Bowling Green, OH 43403 USA.
   [Redfern, Roberta E.] ProMed Toledo Hosp, ProMed Res, Toledo, OH USA.
C3 University System of Ohio; Bowling Green State University
RP Tank, JC (通讯作者)，ProMed Toledo Hosp, 2121 Hughes Dr,310, Toledo, OH 43606 USA.
EM Jason.tankmd@promedica.org; gregory.georgiadismd@promedica.org;
   jeffrey.bairmd@promedica.org; alexi.rice@promedica.org;
   kristin.gardner@promedica.org; jchen@bgsu.edu;
   roberta.redfern@promedica.org
RI georgiadis, gregory/AAO-8347-2020
OI georgiadis, gregory/0000-0001-6477-5700; Redfern,
   Roberta/0000-0001-9883-2910
CR Ahearn C, 2009, OSTOMY WOUND MANAG, V55, P22
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NR 29
TC 1
Z9 2
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD JUN
PY 2021
VL 90
IS 6
BP 1061
EP 1066
DI 10.1097/TA.0000000000003157
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA TC0GW
UT WOS:000668324000034
PM 33755640
DA 2026-07-24
ER
PT J
AU Diehm, YF
   Fischer, S
   Gazyakan, E
   Hundeshagen, G
   Kotsougiani-Fischer, D
   Falkner, F
   Kneser, U
   Hirche, C
AF Diehm, Yannick F.
   Fischer, Sebastian
   Gazyakan, Emre
   Hundeshagen, Gabriel
   Kotsougiani-Fischer, Dimitra
   Falkner, Florian
   Kneser, Ulrich
   Hirche, Christoph
TI Negative pressure wound therapy as an accelerator and stabilizer for
   incorporation of artificial dermal skin substitutes - A retrospective,
   non-blinded, and non-randomized comparative study
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Artificial dermal skin substitutes (ADSS); Negative pressure wound
   therapy (NPWT); Split thickness skin graft; Success rate;
   Vascularization
ID REGENERATION TEMPLATE; INTEGRA; RECONSTRUCTION; DEFECTS; DEVICE; BURNS
AB Background: Artificial dermal skin substitutes (ADSS) in combination with split-thickness skin grafts (STSG) are a valuable option for reconstruction of skin- and soft tissue-defects. However, successful incorporation of ADSS can be limited by various factors. We investigated the anticipated benefits of negative pressure wound therapy (NPWT) as an adjunct to support integration of ADSS, in a retrospective, comparative cohort study.
   Patients and methods: We performed a retrospective, non-blinded, non-randomized comparative study including 86 patients with various soft-tissue defects, managed by application of either ADSS with or without NPWT based on the surgeon's preference. Outcome measurements comprised ADSS and skin graft take rates and analysis of treatment duration and time to wound healing. Additionally, patients were analyzed for the occurrence of hematoma, seroma, wound infection, and lack of substitute or skin graft adhesion.
   Results: Demographic data and individual risk factors did not differ with statistical significance between both groups. The combination of ADSS with NPWT led to significantly improved rates of ADSS integration (89 vs. 70.1%; p = 0.035) and skin graft take (91 vs. 76%; p = 0.049) compared to standard wound dressings without NPWT. In addition, while differences in the incidence of seroma were neglectable, NPWT application led to significantly reduced rates of infection of ADSS (2.2 vs. 7.3%; p = 0.043). Moreover, STSG could be performed on average 4 days earlier with the application of NPWT (p = 0.031).
   Conclusions: The addition of NPWT to ADSS is a helpful adjunct that reduces time of incorporation and vascularization and improves clinical success rates. (C) 2020 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Diehm, Yannick F.; Fischer, Sebastian; Gazyakan, Emre; Hundeshagen, Gabriel; Kotsougiani-Fischer, Dimitra; Falkner, Florian; Kneser, Ulrich; Hirche, Christoph] Heidelberg Univ, Burn Trauma Ctr, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg,Microsurg, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
C3 Ruprecht Karls University Heidelberg
RP Hirche, C (通讯作者)，Heidelberg Univ, Trauma Ctr Ludwigshafen, Burn Trauma Ctr, Dept Hand Plast & Reconstruct Surg,Microsurg, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
EM Christoph.Hirche@bgu-ludwigshafen.de
RI Gazyakan, Emre/HLW-5585-2023; Fischer, Sebastian/AEX-5429-2022
OI , Sebastian/0000-0003-3445-1902
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NR 18
TC 24
Z9 28
U1 0
U2 5
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD FEB
PY 2021
VL 74
IS 2
BP 357
EP 363
DI 10.1016/j.bjps.2020.08.041
EA JAN 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TC4DR
UT WOS:000668591700013
PM 32893153
DA 2026-07-24
ER
PT J
AU Song, ZH
   Guo, XJ
   Zhang, XL
AF Song, Zhihong
   Guo, Xiaojuan
   Zhang, Xiaoli
TI Effects of topical oxygen therapy on chronic traumatic wounds and its
   impact on granulation tissue
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Chronic traumatic wounds; topical oxygen therapy; efficacy; granulation
   tissue
AB Objective: To evaluate the effects of topical oxygen therapy and its impacts on granulation tissue in patients with chronic traumatic wounds. Method: A total of 112 patients with chronic traumatic wounds were randomly divided into the control group (n=56, receiving negative-pressure wound therapy) and the intervention group (n=56, receiving negative-pressure wound therapy plus topical oxygen therapy) using a random number table and they were treated continuously for 2 weeks. Then, the scores from the Pressure Ulcer Scale for Healing (PUSH), the coverage rate of granulation tissue, the severity of pain and Transcutaneous Oxygen Partial Pressure (TcPO2) before and after treatment were compared between the two groups. Also, the bacterial culture-positive rate, the healing rate and the healing time were compared between the two groups. Results: The PUSH scores were significantly decreased after treatment compated to those before treatment in the two groups, and those in the intervention group were lower than those in the control group (all P<0.05). The coverage rate of granulation tissue gradually increased in the two groups from day 3 to day 14 after treatment, with that in the intervention group being higher than in the control group during the same period (all P<0.05). The bacterial culture-positive rate that was detected was significantly lower after treatment than that before treatment in the intervention group, and lower in the intervention group than in the control group after treatment (all P<0.05). The VAS scores significantly decreased and TcPO2 increased after treatment compared to those before treatment in the two groups, with changes in the intervention group being more significant than those in the control group (all P<0.05). During the 3-month follow-up, the wound healing rate was higher and the healing time shorter in the intervention group than those in the control group (all P<0.05). Conclusion: Negative-pressure wound therapy plus topical oxygen therapy can substantially increase the coverage rate of granulation tissue and TcPO2 at the traumatic site, thus facilitating the healing process and shortening the time for healing. So, the efficacy of negative-pressure wound therapy in combination with topical oxygen therapy is more effective in treating patients with chronic traumatic wounds than negative-pressure wound therapy alone.
C1 [Song, Zhihong] Inner Mongolia Med Univ, Affiliated Hosp, Dept Pulmonary & Crit Care Med, Hohhot, Mongolia.
   [Guo, Xiaojuan] Inner Mongolia Med Univ, Affiliated Hosp, Dept Gastrointestinal Surg, Hohhot, Mongolia.
   [Zhang, Xiaoli] Inner Mongolia Med Univ, Affiliated Hosp, Dept Surg Clin, 1 Tongdao St, Hohhot 010050, Mongolia.
C3 Inner Mongolia Medical University; Inner Mongolia Medical University;
   Inner Mongolia Medical University
RP Zhang, XL (通讯作者)，Inner Mongolia Med Univ, Affiliated Hosp, Dept Surg Clin, 1 Tongdao St, Hohhot 010050, Mongolia.
EM zxl15047809819@126.com
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NR 22
TC 12
Z9 16
U1 0
U2 8
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2021
VL 13
IS 6
BP 7294
EP 7299
PG 6
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA TC4EZ
UT WOS:000668595100097
PM 34306496
DA 2026-07-24
ER
PT J
AU Cain, CJ
   Margolis, M
   Lazar, JF
   Henderson, H
   Hamm, M
   Malouf, S
   Khaitan, PG
AF Cain, Caitlin J.
   Margolis, Marc
   Lazar, John F.
   Henderson, Hayley
   Hamm, Margaret
   Malouf, Stefanie
   Khaitan, Puja Gaur
TI Short and long-term outcomes of surgical intervention for empyema in the
   post-fibrinolytic era
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Empyema; Open window Thoracostomy; Bronchopleural fistula
ID TISSUE-PLASMINOGEN ACTIVATOR; VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Background Open window thoracostomy (OWT) is indicated for patients with bronchopleural fistula (BPF) or trapped lung in the setting of empyema refractory to non-surgical interventions. We investigated the role of OWT in the era of minimally invasive surgeries, endobronchial valves and fibrinolytic therapy. Methods A retrospective chart review of all patients who underwent OWT at a single institution from 2010 to 2020 was performed. Indications for the procedure as well as operative details and morbidity and mortality were evaluated to determine patient outcomes for OWT. Results Eighteen patients were identified for the study. The most common indication for OWT was post-resectional BPF (n = 9). Prior to OWT, n = 11 patients failed other surgical or minimally invasive interventions. Patient comorbidities were quantified with the Charlson Comorbidity index (n = 11 score >= 5, 10-year survival <= 21%). Three (16.7%) patients died < 30 days post-operatively and 12 (66%) patients were deceased by the study's end (overall survival 24.0 +/- 32.2 months). Mean number of ribs resected were 2.5 +/- 1.2 (range 1-6) with one patient having 6 ribs removed. Patients were managed with negative pressure wound therapy (n = 9) or Kerlix packing (n = 9). Eleven patients (61.6%) underwent delayed closure (mean time from index surgery to closure 4.8 +/- 6.7 months). Conclusions Our study illustrates the significant comorbidities of patients undergoing OWT, the poor outcomes therein, and pitfalls associated with this procedure. We show that negative pressure wound therapy can be utilized as potential way to obliterate the pleural space and manage an open chest in the absence of an airleak; however, OWT procedures continue to be extremely morbid.
C1 [Cain, Caitlin J.; Margolis, Marc; Lazar, John F.; Khaitan, Puja Gaur] Georgetown Univ, Sch Med, Medstar Washington Hosp Ctr, Dept Gen Surg, 110 Irving St,NW G253, Washington, DC 20010 USA.
   [Margolis, Marc; Lazar, John F.; Henderson, Hayley; Hamm, Margaret; Malouf, Stefanie; Khaitan, Puja Gaur] Georgetown Univ, Sch Med, Medstar Washington Hosp Ctr, Div Thorac Surg, 110 Irving St,NW G253, Washington, DC 20010 USA.
C3 MedStar Washington Hospital Center; Georgetown University; Georgetown
   University; MedStar Washington Hospital Center
RP Khaitan, PG (通讯作者)，Georgetown Univ, Sch Med, Medstar Washington Hosp Ctr, Dept Gen Surg, 110 Irving St,NW G253, Washington, DC 20010 USA.; Khaitan, PG (通讯作者)，Georgetown Univ, Sch Med, Medstar Washington Hosp Ctr, Div Thorac Surg, 110 Irving St,NW G253, Washington, DC 20010 USA.
EM Puja.G.Khaitan@medstar.net
RI Khaitan, Puja/AAQ-6413-2020
OI Khaitan, Puja/0000-0001-8654-062X; Cain-Trivette, Caitlin
   J/0000-0003-4141-275X
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NR 22
TC 8
Z9 9
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD JUL 2
PY 2021
VL 16
IS 1
AR 187
DI 10.1186/s13019-021-01566-z
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA TD2ZT
UT WOS:000669201900001
PM 34215289
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Cramer, P
   Schneider-Burrus, S
   Kovács, M
   Scholl, L
   Podda, M
   Bechara, FG
AF Cramer, P.
   Schneider-Burrus, S.
   Kovacs, M.
   Scholl, L.
   Podda, M.
   Bechara, F. G.
TI Hidradenitis suppurativa /acne inversa-surgical options, reconstruction
   and combinations with drug therapies-an update
SO HAUTARZT
LA German
DT Article
DE Reconstructive surgical procedures; Immunomodulation; Wound healing;
   Negative-pressure wound therapy; Recurrence rate
ID TISSUE-SPARING EXCISION; AXILLARY HIDRADENITIS; INVERSA/HIDRADENITIS
   SUPPURATIVA; WIDE EXCISION; SURGERY; GLUTEAL; MANAGEMENT; EFFICACY;
   CLOSURE; GROIN
AB Hidradenitis suppurativa/acne inversa (HS/AI) is a chronic inflammatory skin disease whose treatment includes both conservative and surgical treatment options. In Hurley stages II and III, surgical resection of irreversibly destroyed tissue should be the objective. For this purpose several resection techniques exist, which differ primarily with regard to their invasiveness and tendency to recur. To date, there is no generally accepted consensus on the use of different resection and reconstruction techniques or the inclusion of drug therapies in the overall therapeutic concept.
C1 [Cramer, P.; Scholl, L.; Bechara, F. G.] Klin Ruhr Univ Bochum, St Josef Hosp, Katholisches Klin Bochum, Klin Dermatol Venerol & Allergol, Gudrunstr 56, D-44791 Bochum, Germany.
   [Schneider-Burrus, S.] Havelklin Berlin, Zentrum Dermatochirurg, Berlin, Germany.
   [Kovacs, M.; Podda, M.] Goethe Univ Frankfurt, Hautklin Klin Darmstadt, Akad Lehrkrankenhaus, Darmstadt, Germany.
C3 Ruhr University Bochum; Goethe University Frankfurt
RP Bechara, FG (通讯作者)，Klin Ruhr Univ Bochum, St Josef Hosp, Katholisches Klin Bochum, Klin Dermatol Venerol & Allergol, Gudrunstr 56, D-44791 Bochum, Germany.
EM falk.bechara@klinikum-bochum.de
OI Schneider-Burrus, Sylke/0000-0002-9740-6845
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NR 89
TC 6
Z9 9
U1 1
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0017-8470
EI 1432-1173
J9 HAUTARZT
JI Hautarzt
PD AUG
PY 2021
VL 72
IS 8
SI SI
BP 692
EP 699
DI 10.1007/s00105-021-04864-8
EA JUL 2021
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA TS1UW
UT WOS:000670204000002
PM 34228137
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Notorgiacomo, G
   Klug, J
   Rapp, S
   Boyce, ST
   Schutte, SC
AF Notorgiacomo, Gabrielle
   Klug, Justin
   Rapp, Scott
   Boyce, Steven T.
   Schutte, Stacey C.
TI A bioreactor for studying negative pressure wound therapy on skin grafts
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bioreactor; NPWT; skin graft; skin substitute
ID VACUUM-ASSISTED CLOSURE; DRESSING METHODS; LEG ULCERS; SUBSTITUTES;
   INTEGRATION; MANAGEMENT; EFFICACY; DEVICE
AB Negative pressure wound therapy (NPWT) has become the prevailing standard of care for treating complex soft tissue wounds and is now being considered for use in alternative applications including improving skin graft take. While it is generally agreed that negative pressure leads to improved wound healing, universal consensus on its optimal application is not supported in the literature. We describe the design and validation of a bioreactor to determine the prospective benefits of NPWT on skin grafts and engineered skin substitutes (ESS). Clinically relevant pressures were applied, and the native human skin was able to withstand greater negative pressures than the engineered substitutes. Both skin types were cultured under static, flow-only, and -75 mm Hg conditions for 3 days. While it remained intact, there was damage to the epidermal-dermal junction in the ESS after application of negative pressure. The normal skin remained viable under all culture conditions. The engineered skin underwent apoptosis in the flow-only group; however, the application of negative pressure reduced apoptosis. Vascular endothelial growth factor levels were significantly higher in the normal flow-only group, 152.0 +/- 75.1 pg/mg protein, than the other culture conditions, 81.6 +/- 35.5 pg/mg for the static and 103.6 +/- pg/mg for the negative pressure conditions. The engineered skin had a similar trend but the differences were not significant. This bioreactor design can be used to evaluate the impacts of NPWT on the anatomy and physiology of skin to improve outcomes in wounds after grafting with normal or engineered skin.
C1 [Notorgiacomo, Gabrielle; Klug, Justin; Schutte, Stacey C.] Univ Cincinnati, Dept Biomed Engn, Cincinnati, OH USA.
   [Rapp, Scott] Norton Childrens Hosp, Div Plast Surg, Louisville, KY USA.
   [Rapp, Scott] Kentucky Ctr Cosmet & Reconstruct Surg, Louisville, KY USA.
   [Rapp, Scott; Boyce, Steven T.; Schutte, Stacey C.] Shriners Hosp Children Cincinnati, Res Dept, Cincinnati, OH USA.
   [Boyce, Steven T.] Univ Cincinnati, Dept Surg, 231 Bethesda Ave, Cincinnati, OH 45267 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati
RP Schutte, SC (通讯作者)，2901 Woodside Dr,501 Engn Res Ctr, Cincinnati, OH 45221 USA.
EM stacey.schutte@uc.edu
RI Schutte, Stacey/L-9039-2019
OI Schutte, Stacey/0000-0002-8092-5067
FU Shriners Hospitals for Children; University of Cincinnati
FX Shriners Hospitals for Children; University of Cincinnati
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   Shon YS, 2014, ARCH PLAST SURG-APS, V41, P668, DOI 10.5999/aps.2014.41.6.668
   Supp AP, 2005, J BURN CARE REHABIL, V26, P238, DOI 10.1097/01.BCR.0000162152.28330.6C
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   U.S. Food and Drug Administration, 2018, NON POW SUCT APP DEV
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
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NR 47
TC 6
Z9 6
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR
PY 2022
VL 19
IS 3
BP 633
EP 642
DI 10.1111/iwj.13661
EA JUL 2021
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ZH2HY
UT WOS:000670390100001
PM 34235863
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Shi, H
   Zhu, L
   Jiang, ZL
   Huang, ZH
   Wu, XT
AF Shi, Hang
   Zhu, Lei
   Jiang, Zan-Li
   Huang, Zhi-Hao
   Wu, Xiao-Tao
TI The use of incisional vacuum-assisted closure system following one-stage
   incision suture combined with continuous irrigation to treat early deep
   surgical site infection after posterior lumbar fusion with
   instrumentation
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Vacuum-assisted closure; One-stage incision suture; Continuous
   irrigation; Early deep surgical site infection; Posterior lumbar fusion
   with instrumentation
ID PRESSURE WOUND THERAPY; SPINAL INSTRUMENTATION
AB Background Previous reports concerning deep surgical site infection (SSI) after posterior spinal instrumentation treated with vacuum-assisted closure (VAC) system indicated that most patients must suffer from a delayed incision suture. To date, there are no published reports about the application of incisional VAC following a one-stage incision suture in the treatment of spinal infections. The purpose of this study was to evaluate the feasibility and efficacy of using an incisional VAC system following a one-stage incision suture combined with continuous irrigation to treat early deep SSI after posterior lumbar fusion with instrumentation. Methods Twenty-one patients who were identified as early deep SSI after posterior lumbar fusion with instrumentation were treated by incisional VAC following a one-stage incision suture combined with continuous irrigation at our spine surgery center between January 2014 and March 2020. Detailed data from medical records were collected and analyzed, including age, gender, primary diagnosis, original operation, number of VAC dressing changes, duration of continuous irrigation, hospital stay, risk factors for infection, bacteria type, and laboratory data. Clinical efficacy was assessed using the pre- and postoperative visual analog scale (VAS) for back pain and Kirkaldy-Willis functional criteria by regular follow-up. Results All the patients were cured and retained implants with an average of 1.9 times of VAC dressing replacement, and an average of 10.2 days of continuous irrigation. There were significant differences between pre-operation and post-operation in ESR, CRP, and VAS score of back pain, respectively (P < 0.05). The satisfactory rate was 90.5% according to Kirkaldy-Willis functional criteria. One patient developed a back skin rash with itching around the wound because of long-time contact with the VAC dressing. There was no recurrent infection or other complications during follow-up. Conclusions Our preliminary results support that the treatment protocol is feasible and effective to treat early deep SSI following posterior lumbar fusion with instrumentation.
C1 [Shi, Hang; Zhu, Lei; Jiang, Zan-Li; Huang, Zhi-Hao; Wu, Xiao-Tao] Southeast Univ, Sch Med, Zhongda Hosp, Dept Spine Surg, Nanjing 210009, Jiangsu, Peoples R China.
C3 Southeast University - China
RP Wu, XT (通讯作者)，Southeast Univ, Sch Med, Zhongda Hosp, Dept Spine Surg, Nanjing 210009, Jiangsu, Peoples R China.
EM wuxiaotaospine@seu.edu.cn
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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NR 26
TC 9
Z9 10
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD JUL 9
PY 2021
VL 16
IS 1
AR 445
DI 10.1186/s13018-021-02588-y
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA TI2XM
UT WOS:000672658200003
PM 34243798
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Serna, C
   Serna, JJ
   Caicedo, Y
   Padilla, N
   Gallego, LM
   Salcedo, A
   Rodríguez-Holguín, F
   González-Hadad, A
   García, A
   Herrera, MA
   Parra, MW
   Ordonez, CA
AF Serna, Carlos
   Julian Serna, Jose
   Caicedo, Yaset
   Padilla, Natalia
   Gallego, Linda M.
   Salcedo, Alexander
   Rodriguez-Holguin, Fernando
   Gonzalez-Hadad, Adolfo
   Garcia, Alberto
   Alain Herrera, Mario
   Parra, Michael W.
   Ordonez, Carlos A.
TI Damage control surgery for splenic trauma: "preserve an organ - preserve
   a life"
SO COLOMBIA MEDICA
LA English
DT Review
DE Spleen; injury severity score; splenectomy; laparotomy; focused
   assessment with sonography for trauma; advanced trauma life support
   care; damage control surgery; negative-pressure wound therapy; balloon
   occlusion; REBOA
ID NONOPERATIVE MANAGEMENT; ARTERY EMBOLIZATION; BLUNT; INJURY; FAILURE;
   STRATEGIES; ADULTS
AB The spleen is one of the most commonly injured solid organs of the abdominal cavity and an early diagnosis can reduce the associated mortality. Over the past couple of decades, management of splenic injuries has evolved to a prefered non-operative approach even in severely injured cases. However, the optimal surgical management of splenic trauma in severely injured patients remains controversial. This article aims to present an algorithm for the management of splenic trauma in severely injured patients, that includes basic principles of damage control surgery and is based on the experience obtained by the Trauma and Emergency Surgery Group (CTE) of Cali, Colombia. The choice between a conservative or a surgical approach depends on the hemodynamic status of the patient. In hemodynamically stable patients, a computed tomography angiogram should be performed to determine if non-operative management is feasible and if angioembolization is required. While hemodynamically unstable patients should be transferred immediately to the operating room for damage control surgery, which includes splenic packing and placement of a negative pressure dressing, followed by angiography with embolization of any ongoing arterial bleeding. It is our recommendation that both damage control principles and emerging endovascular technologies should be applied to achieve splenic salvage when possible. However, if surgical bleeding persists a splenectomy may be required as a definitive lifesaving maneuver.
C1 [Serna, Carlos; Julian Serna, Jose; Salcedo, Alexander; Gonzalez-Hadad, Adolfo; Garcia, Alberto; Alain Herrera, Mario; Ordonez, Carlos A.] Univ Valle, Fac Salud, Escuela Med, Dept Surg,Div Trauma & Acute Care Surg, Cali, Colombia.
   [Julian Serna, Jose; Salcedo, Alexander; Gonzalez-Hadad, Adolfo; Alain Herrera, Mario] Hosp Univ Valle, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Julian Serna, Jose; Salcedo, Alexander; Rodriguez-Holguin, Fernando; Garcia, Alberto; Ordonez, Carlos A.] Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Julian Serna, Jose; Gallego, Linda M.; Salcedo, Alexander; Garcia, Alberto; Ordonez, Carlos A.] Univ ICESI, Cali, Colombia.
   [Caicedo, Yaset; Padilla, Natalia] Fdn Valle Lili, Ctr Invest Clin CIC, Cali, Colombia.
   [Gonzalez-Hadad, Adolfo] Ctr Med Imbanaco, Cali, Colombia.
   [Parra, Michael W.] Broward Gen Level I Trauma Ctr, Dept Trauma Crit Care, Ft Lauderdale, FL USA.
C3 Universidad del Valle; Universidad del Valle; Fundacion Valle del Lili;
   Universidad ICESI; Fundacion Valle del Lili
RP Ordonez, CA (通讯作者)，Univ Valle, Fac Salud, Escuela Med, Dept Surg,Div Trauma & Acute Care Surg, Cali, Colombia.; Ordonez, CA (通讯作者)，Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.; Ordonez, CA (通讯作者)，Univ ICESI, Cali, Colombia.
EM ordonezcarlosa@gmail.com
RI ; Herrera, Mario Alain/LRB-9290-2024
OI Gallego, Linda Melissa/0000-0001-9081-5016; Salcedo Cadavid,
   Alexander/0000-0001-8187-0638; Herrera, Mario Alain/0000-0002-4526-7636;
   Serna, José Julián/0000-0001-9829-8930; Padilla-Londoño,
   Natalia/0000-0003-3292-6919
CR Ordoñez CA, 2012, J TRAUMA ACUTE CARE, V73, P1074, DOI 10.1097/TA.0b013e31826fc780
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NR 32
TC 4
Z9 6
U1 0
U2 8
PU CORPORACION EDITORA MEDICA VALLE
PI CALI
PA UNIV VALLE, BLDG 118 FACULTY HEALTH, CALLE 4B 36-00, CALI, 00000,
   COLOMBIA
SN 1657-9534
J9 COLOMB MEDICA
JI Colomb. Medica
PY 2021
VL 52
IS 2
AR e4084794
DI 10.25100/cm.v52i2.4794
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TK0ND
UT WOS:000673865600003
PM 34188324
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Martí, MTC
   Fernandez-Gonzalez, S
   Martí, MD
   Pla, MJ
   Barahona, M
   Ponce, J
AF Climent Marti, Maria Teresa
   Fernandez-Gonzalez, Sergi
   Dolores Marti, Maria
   Jesus Pla, Maria
   Barahona, Marc
   Ponce, Jordi
TI Prophylactic incisional negative pressure wound therapy for gynaecologic
   malignancies
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE gynecologic neoplasms; laparotomy; negative-pressure wound therapy;
   postoperative care; wound healing
ID SURGICAL SITE INFECTION; LAPAROTOMY; IMPACT; COST
AB Wound complications are an important cause of postoperative morbidity among patients with gynaecologic malignancies. We evaluated whether the placement of closed-incisional negative pressure therapy (ciNPT) at the time of laparotomy for gynaecologic cancer surgery reduced wound complication rates. A retrospective cohort study with primary wound closure performed by a gynaecologic oncologist was carried out. We evaluated two cohorts of patients who underwent surgery in 2017 with standard closure and patients who underwent surgery in 2019 with the placement of prophylactic ciNPT. Postoperative outcomes were examined. A total of 143 patients were included, 85 (59.4%) vs 58 (40.6%) with standard closure and ciNPT, respectively. The total complication rate in our sample was 38.71%. The rate of surgical complications in patients treated with ciNPT was 6.9% compared with 31.8% (P = .000) in patients treated with standard closure. In the analysis of complications, a significant reduction in infections (17.1%), seromas (15.4%), and wound dehiscence (17.1%) were observed when ciNPT was applied. The median hospital stay was 8 vs 6 days in the standard closure vs ciNPT groups (P = .048). The use of the prophylactic ciNPT following a laparotomy may decrease wound complications and hospital stays in oncological patients. ciNPT could be considered as part of clinical practice in patients at high risk of wound complications, such as patients with gynaecological malignancies.
C1 [Climent Marti, Maria Teresa; Fernandez-Gonzalez, Sergi; Dolores Marti, Maria; Barahona, Marc; Ponce, Jordi] Hosp Univ Bellvitge, Dept Gynecol, Barcelona, Spain.
   [Jesus Pla, Maria] Hosp Univ Bellvitge, Dept Gynecol, Multidisciplinary Breast Canc Unit, Barcelona, Spain.
C3 Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital
RP Fernandez-Gonzalez, S (通讯作者)，Dept Gynecol, Carrer Feixa Llarga,Idibell S-N, Barcelona 08907, Spain.
EM sfernandezg@bellvitgehospital.cat
OI Ponce, Jordi/0000-0002-0613-2261; CLIMENT MARTÍ, MARIA
   TERESA/0000-0002-2533-7983
CR Borchardt RA, 2018, JAAPA-J AM ACAD PHYS, V31, P52, DOI 10.1097/01.JAA.0000531052.82007.42
   Cahill C, 2018, INT WOUND J, V15, P740, DOI 10.1111/iwj.12921
   Chambers LM, 2020, AM J OBSTET GYNECOL, V223, DOI 10.1016/j.ajog.2020.05.011
   Chopra K, 2016, PLAST RECONSTR SURG, V137, P1284, DOI 10.1097/PRS.0000000000002024
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   Gombert A, 2018, EUR J VASC ENDOVASC, V56, P442, DOI 10.1016/j.ejvs.2018.05.018
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   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
NR 24
TC 4
Z9 7
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2022
VL 19
IS 2
BP 272
EP 277
DI 10.1111/iwj.13628
EA JUL 2021
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA YH4HX
UT WOS:000673959600001
PM 34268886
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tao, R
   Xue, CY
   Yang, CH
   Simfukwe, K
   Hu, XW
   Wu, X
   Bi, HD
AF Tao, Ran
   Xue, Chunyu
   Yang, Chunhui
   Simfukwe, Keith
   Hu, Xiaowu
   Wu, Xi
   Bi, Hongda
TI Reconstruction of chronic scalp erosion after deep brain stimulation
   surgery
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Local scalp flap; Negative pressure wound therapy; Deep brain
   stimulation; Parkinson's disease
ID SHAPED SKIN INCISION; MANAGEMENT; COMPLICATIONS
AB Objective: To investigate the reconstructive effectiveness for chronic scalp erosion after deep brain stimulation (DBS).
   Background: Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease. However, this surgery is not exempt from hard-ware related complications, especially scalp erosions on scalp. Scalp erosions usually accompanied with chronic infection and wound contamination. If not arrested, infections may spread through the entire equipment which would endanger the patient's life. Along with review of previous literatures, we summarized our experience in the management of scalp erosion and implemented a systemic treatment plan for reconstruction.
   Methods: We retrospectively analyzed the clinical data of patients with chronic scalp erosion after DBS in the past 40 months. The treatment plan was composed of three sequential major steps, including wound care and conservative methods, debridement and local flap, and revaluation of the wound. In each of the cases, wound debridement and local scalp flap repair were conducted, and assisted by negative pressure wound therapy (NPWT) device and double cannula irrigation.
   Results: The local scalp flap survived in all 6 patients. The chronic scalp erosions all healed without refractory. The DBS devices still functioned properly after the treatments in all patients. The average follow-up period was 13.33 months (range: 4 to 23 months), and no infection recurrence or re-erosion of the scalp flap was reported.
   Conclusion: A combination of wound debridement, local scalp flap repair, the use of NPWT device and double cannula irrigation provides effective treatment method for chronic erosion post DBS surgery. (C) 2020 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.
C1 [Tao, Ran; Xue, Chunyu; Bi, Hongda] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd,Yangpu Dist, Shanghai, Peoples R China.
   [Yang, Chunhui; Hu, Xiaowu; Wu, Xi] Second Mil Med Univ, Changhai Hosp, Dept Neurosurg, 168 Changhai Rd,Yangpu Dist, Shanghai, Peoples R China.
   [Simfukwe, Keith] Mordovia Republican Clin Hosp, Dept Neurosurg, Pobedi St, Saransk, Russia.
C3 Naval Medical University; Naval Medical University
RP Bi, HD (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd,Yangpu Dist, Shanghai, Peoples R China.; Wu, X (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Neurosurg, 168 Changhai Rd,Yangpu Dist, Shanghai, Peoples R China.
EM wuxi_smmu@sina.com; bihongda0411@163.com
FU "Digital Equipment of Diagnosis and Treatment" special program of
   National Key Research and Development Plan [2016YFC0105900]
FX This work was supported by "Digital Equipment of Diagnosis and
   Treatment" special program of National Key Research and Development Plan
   (2016YFC0105900) .
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   Park YS, 2011, STEREOT FUNCT NEUROS, V89, P178, DOI 10.1159/000324903
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NR 12
TC 5
Z9 5
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2021
VL 74
IS 8
BP 1807
EP 1813
DI 10.1016/j.bjps.2020.11.045
EA JUL 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TP3GD
UT WOS:000677481000013
PM 33358678
DA 2026-07-24
ER
PT J
AU Li, RY
   Xiang, L
   Lu, JH
   Chen, LZ
   Cai, XS
AF Li, Ruiying
   Xiang, Lei
   Lu, Jinghui
   Chen, Linzhen
   Cai, Xiangsheng
TI First Chinese case report of Helcococcus kunzii in a patient with
   diabetic foot
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Helcococcus kunzii; Diabetic foot; MALDI-TOF-MS; 16S rRNA gene
   sequencing; Case report
ID SP NOV.
AB BackgroundInfection of Helcococcus kunzii(H. kunzii) from diabetic foot wound is rarely reported. This case report describes the infection of H.kunzii and highlights the therapeutic effect on H.kunzii from a diabetic foot wound.Case presentationIn this study, one H. kunzii strain was isolated from a patient with diabetic foot, which was confirmed by 16S rRNA gene analysis and MALDI-TOF-MS. It is the first Chinese case of H. kunzii in a patient with diabetic foot. As a result of the lack of antibiotic sensitivity data and multiple comorbidities, antibiotics were used cautiously, and those administered during the first 3months were ineffective. Then, vacuum sealing drainage (VSD) was applied during hospitalization; no antibiotics were used and the wound healed well.ConclusionsVSD alone may be more effective in treating diabetic feet infected with H. kunzii, which may provide reference for clinical treatment of H. kunzii infection from diabetic foot.
C1 [Li, Ruiying; Lu, Jinghui; Chen, Linzhen] Guangdong Pharmaceut Univ, Clin Lab, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Xiang, Lei; Cai, Xiangsheng] Univ Chinese Acad Sci, Ctr Med Expt, Shenzhen Hosp, Shenzhen, Peoples R China.
C3 Guangdong Pharmaceutical University; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS
RP Cai, XS (通讯作者)，Univ Chinese Acad Sci, Ctr Med Expt, Shenzhen Hosp, Shenzhen, Peoples R China.
EM xiangshengcai@yeah.net
RI Cai, Xiangsheng/GPS-8610-2022
OI Cai, Xiangsheng/0000-0002-6353-8188
FU National Natural Science Foundation of China [81804030]
FX This research was supported by the National Natural Science Foundation
   of China (grant no. 81804030). The funders had no role in study design,
   data collection and analysis, decision on publish, or preparation of the
   manuscript.
CR CALIENDO AM, 1995, J CLIN MICROBIOL, V33, P1638, DOI 10.1128/JCM.33.6.1638-1638.1995
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NR 9
TC 1
Z9 1
U1 0
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD JUL 20
PY 2021
VL 21
IS 1
AR 695
DI 10.1186/s12879-021-06309-y
PG 4
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA TP3RN
UT WOS:000677511300001
PM 34284730
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wu, YJ
   Chen, L
   Mao, XL
   Ru, ZL
   Yu, LY
   Chen, MM
   Wang, JN
   Chen, JJ
   Pang, QJ
AF Wu, Yaojun
   Chen, Liang
   Mao, Xinliang
   Ru, Zhengliang
   Yu, Liying
   Chen, Mimi
   Wang, Jingnan
   Chen, Jiejie
   Pang, Qingjiang
TI Closure of Complex Wounds by a Simple Skin Stretching System Associated
   With Vacuum Sealing Drainage-Clinical Outcome of 34 Patients
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE complex wounds; a simple skin stretching system; vacuum sealing drainage
ID ASSISTED CLOSURE; FASCIOTOMY; THERAPY; SECURE
AB Management of complex wounds with large skin defects presents a real challenge for orthopedic or reconstructive surgeons. We developed a simple skin stretching system associated with vacuum sealing drainage to examine the efficiency and complication. A total of 34 patients with different types of complex wounds were retrospectively included from January 2015 to March 2021. All patients in the study were underwent the treatment by 2 stages. The method was used to the wounds from 4.71 to 169.65 cm(2) with a median defect size of 25.13 cm(2). The median time for wound closure was 11.5 days (range: 5-32 days), although the median absolute reduction was 2.08 cm(2)/day (range: 0.15-25.66 cm(2)/day). Depending on the site of the wounds, the cause of the wound, and the rate of max-width/max-length (W/L), these complex wounds could be separately divided into several groups. There were statistically significant differences in the median value of the above variables (P < .05 Kruskal-Wallis test). The results showed that different anatomical sites had different viscoelastic properties, the complex wounds caused by trauma were easier to close than caused by diabetic foot and the complex wounds in group A (W/L > 0.5) were more difficult to close than in group B (W/L <= 0.5). No major complications were encountered in this study. In summary, the results of our study showed that the simple skin stretching system associated with vacuum sealing drainage was a safe approach for closure of complex wounds. Nevertheless, more attention should be paid to the viscoelasticity of the wounds to ensure closure and avoid undue complications when applying the method.
C1 [Wu, Yaojun; Chen, Liang; Mao, Xinliang; Yu, Liying; Chen, Mimi; Wang, Jingnan; Chen, Jiejie; Pang, Qingjiang] Univ Chinese Acad Sci, Hwa Mei Hosp, Ningbo, Peoples R China.
   [Wu, Yaojun; Chen, Liang; Mao, Xinliang; Yu, Liying; Chen, Mimi; Wang, Jingnan; Chen, Jiejie; Pang, Qingjiang] Univ Chinese Acad Sci, Ningbo Inst Life & Hlth Ind, Ningbo, Peoples R China.
   [Ru, Zhengliang] Cixi Third Peoples Hosp, Ningbo, Peoples R China.
C3 Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS; Chinese Academy of Sciences; University of Chinese Academy of
   Sciences, CAS
RP Chen, L (通讯作者)，Univ Chinese Acad Sci, Hwa Mei Hosp, Dept Orthoped, Ningbo Hosp2, Ningbo, Zhejiang, Peoples R China.
EM alanchen1@aliyun.com
FU Medical Scientific Research Foundation of Zhejiang Province, China
   [2020KY843, 2015KYB342]; Key Program of Ningbo Natural Science
   Foundation, China [2016A610146]; HwaMei Reasearch Foundation of Ningbo
   No. 2 Hospital, China [2019HMKY10]
FX This work was supported by supported by Medical Scientific Research
   Foundation of Zhejiang Province, China (Grant No. 2020KY843,
   2015KYB342); the Key Program of Ningbo Natural Science Foundation, China
   (Grant No. 2016A610146); HwaMei Reasearch Foundation of Ningbo No. 2
   Hospital, China (Grant No. 2019HMKY10).
CR Barnea Y, 2004, PLAST RECONSTR SURG, V113, P862, DOI 10.1097/01.PRS.0000105339.41838.D2
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NR 33
TC 2
Z9 2
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2023
VL 22
IS 3
BP 555
EP 562
AR 15347346211032046
DI 10.1177/15347346211032046
EA JUL 2021
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA O1KU3
UT WOS:000678003300001
PM 34279133
DA 2026-07-24
ER
PT J
AU Peinemann, F
   Labeit, A
AF Peinemann, Frank
   Labeit, Alexander
TI Negative pressure wound therapy: A systematic review of randomized
   controlled trials from 2000 to 2017
SO JOURNAL OF EVIDENCE BASED MEDICINE
LA English
DT Article
DE negative pressure wound therapy; randomized controlled trials;
   systematic review
ID VACUUM-ASSISTED CLOSURE; SURROGATE END-POINTS; CLINICAL-TRIALS;
   FUNDAMENTALS
AB BackgroundNegative pressure wound therapy (NPWT) proposes to provide better wound healing than standard wound management. Evidence quality of randomized controlled trials (RCTs) varies.
   MethodsWe included participants with any kind of wounds and commercial as well as the homemade NPWT system. Comparators were any other wound dressing including variant NPWTs. We included RCTs randomizing patients or wounds in parallel or crossover designs. We searched PubMed and Cochrane Library on January 03, 2018. We assessed the risk of bias according to Cochrane and appropriateness of clinical endpoints according to the Food and Drug Administration (FDA).
   ResultsWe included 93 RCTs originating in 30 countries, 70 studies on open wounds and 23 studies on closed wounds. With respect to random sequence generation, we judged an unclear or high risk of bias in 50% (47 of 93) studies. With respect to allocation concealment, we judged an unclear or high risk of bias in 90% (84 of 93). We identified 41% (38 of 93) studies that based their conclusion on not appropriate endpoints.
   ConclusionsHigh risk of bias concerning random sequence generation and allocation concealment limited the credibility of the majority of 93 included RCTs on NPWT. A low risk of bias can and should be achieved with both items, and we recommend to align future RCTs to Cochrane. Many primary clinical endpoints were deemed not valid for making inferences on the efficacy of NPWT. We recommend using patient-centered endpoints as requested by the FDA and suggested in the present systematic review.
C1 [Peinemann, Frank] Univ Hosp, Childrens Hosp, Kerpener Str 62, D-50937 Cologne, Germany.
   [Peinemann, Frank] FOM Univ Appl Sci Econ & Management, Essen, Germany.
   [Labeit, Alexander] Univ Manchester, Fac Biol Med & Hlth Sci, Div Populat Hlth Hlth Serv Res & Primary Care, Manchester, Lancs, England.
C3 University of Cologne; University of Manchester
RP Peinemann, F (通讯作者)，Univ Hosp, Childrens Hosp, Kerpener Str 62, D-50937 Cologne, Germany.
EM pubmedprjournal@gmail.com
RI /H-2800-2019
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NR 33
TC 20
Z9 22
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1756-5383
EI 1756-5391
J9 J EVID-BASED MED
JI J Evid.-Based Med.
PD MAY
PY 2019
VL 12
IS 2
BP 125
EP 132
DI 10.1111/jebm.12324
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA VK3IO
UT WOS:000678092300005
PM 30460777
OA Bronze
DA 2026-07-24
ER
PT J
AU Myllykangas, HM
   Berg, LT
   Husso, A
   Halonen, J
AF Myllykangas, Heidi-Mari
   Berg, Leena T.
   Husso, Annastina
   Halonen, Jari
TI Negative pressure wound therapy in the treatment of deep sternal wound
   infections - a critical appraisal
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; mediastinitis; sternotomy; cardiac
   surgery; surgical flaps
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; MUSCLE FLAPS;
   MANAGEMENT; MORTALITY; SURGERY
AB Introduction. Negative pressure wound therapy (NPWT) has widely become the first-line option in the treatment of deep sternal wound infections. After several positive reports in comparison with conventional treatment, very recent studies comparing NPWT with early reconstruction have favored the latter. Our aim was to evaluate the effectiveness and safety of NPWT in comparison with early flap reconstruction. Materials and methods. We concluded a retrospective analysis of 125 patients with deep sternal wound infection treated in a single institution between the years 2006 and 2018. NPWT became the first-line treatment in our hospital in 2011. The study group consisted of 55 patients treated primarily with NPWT with or without subsequent flap reconstruction. The control group consisted of 60 patients treated with flap reconstruction without prior NPWT. Ten patients with an immediate re-fixation and direct wound closure were excluded. Results. There were no significant differences between the two groups concerning the type or urgency of the original open-heart surgery, age, gender, or co-morbidities. In the NPWT group there was significantly higher mortality (p = .002), longer stay in the intensive care unit (p = .028), and in the university hospital (p < .001) as well as higher number of operations (p < .001). However, there were somewhat more surgical complications in the control group as well as a higher number of distant flap reconstructions. Overall, five patients suffered from NPWT associated bleeding. Conclusion. Our results raise concerns about the wide use of NPWT as a first-line treatment of deep sternal wound infections. Further evaluative studies are warranted to confirm the results.
C1 [Myllykangas, Heidi-Mari] Kuopio Univ Hosp, Dept Plast Surg, PL 100, Kuopio 70029, Finland.
   [Myllykangas, Heidi-Mari; Halonen, Jari] Univ Eastern Finland, Fac Med, Kuopio, Finland.
   [Berg, Leena T.] Kainuu Cent Hosp, Dept Plast Surg, Kajaani, Finland.
   [Husso, Annastina; Halonen, Jari] Kuopio Univ Hosp, Dept Cardiothorac Surg, Kuopio, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Eastern Finland; Kuopio
   University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital
RP Myllykangas, HM (通讯作者)，Kuopio Univ Hosp, Dept Plast Surg, PL 100, Kuopio 70029, Finland.
EM Heidi.myllykangas@kuh.fi3
RI Halonen, Jari/K-9329-2018
OI Myllykangas, Heidi-Mari/0000-0003-0542-987X
FU Kuopio University Hospital Research Foundation
FX This study was supported by the Kuopio University Hospital Research
   Foundation.
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NR 31
TC 6
Z9 6
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PD DEC 1
PY 2021
VL 55
IS 6
BP 327
EP 332
DI 10.1080/14017431.2021.1955963
EA JUL 2021
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA XL3LP
UT WOS:000678353900001
PM 34304643
OA Bronze
DA 2026-07-24
ER
PT J
AU Haspeslagh, M
   Van Hecke, LL
   Hermans, K
   Chiers, K
   Pint, E
   Wilmink, JM
   Martens, AM
AF Haspeslagh, Maarten
   Van Hecke, Lore L.
   Hermans, Katleen
   Chiers, Koen
   Pint, Eva
   Wilmink, Jacintha M.
   Martens, Ann M.
TI Limited added value of negative pressure wound therapy compared with
   calcium alginate dressings for second intention healing in a
   noncontaminated and contaminated equine distal limb wound model
SO EQUINE VETERINARY JOURNAL
LA English
DT Article
DE calcium alginate dressing; horse; horse wound healing; in vivo wound
   model; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; BACTERIAL LOAD; MANUKA HONEY; MANAGEMENT
AB Background Distal limb wounds in horses often show aberrant healing due to a slow inflammatory response. In human medicine, negative pressure wound therapy (NPWT) is used for the treatment of chronic wounds with a similar inflammatory response. Objectives To compare the effect of NPWT to calcium alginate dressings on the healing of (non) contaminated equine distal limb wounds. Study design Controlled experiment. Methods Circular wounds were created on the left and right dorsomedial metacarpus of 10 horses. In five horses, the wounds were contaminated with Staphylococcus aureus and Pseudomonas aeruginosa. In all horses, one limb was treated with NPWT, the other with calcium alginate dressings. Treatments were applied during nine days for noncontaminated wounds and six days for contaminated wounds. Noninvasive (clinical assessment, bacteriology swabs, thermographic images and wound dimensions) and invasive (biopsies for histology and growth factor analysis) measurements were taken regularly for 71 and 29 days respectively. Effects of selected parameters on continuous dependent variables were analysed using ANOVA, while for discrete dependent variables, logistic regression was applied. Results In noncontaminated wounds, there was significantly less wound retraction in the early healing stages when treated with NPWT (mean difference [95% CI] = 19.2% [13.3%-25.1%]; P = .005), although wound size was not significantly different between NPWT and control wounds at later healing stages. Noncontaminated control wounds had a significantly higher neutrophil influx (OR [95% CI] = 1.99 [1.49-2.66]; P < .001) and lower macrophage influx (OR [95% CI] = 0.75 [0.60-0.93]; P = .008) compared with NPWT-treated wounds. Bacterial load and the presence of growth factors did not differ between treatments in noncontaminated wounds. In contaminated wounds, no differences between treatments were observed in wound size, histological parameters, bacterial load or growth factor concentration. Main limitations Sample size is small. Conclusions No long-term advantage was detected with NPWT compared with calcium alginate dressings in noncontaminated or contaminated equine distal limb wounds healing by second intention.
C1 [Haspeslagh, Maarten; Van Hecke, Lore L.; Pint, Eva; Martens, Ann M.] Univ Ghent, Fac Vet Med, Dept Surg & Anaesthesiol Domest Anim, Merelbeke, Belgium.
   [Hermans, Katleen; Chiers, Koen] Univ Ghent, Fac Vet Med, Dept Pathol Bacteriol & Poultry Dis, Merelbeke, Belgium.
   [Wilmink, Jacintha M.] Woumarec, Wageningen, Netherlands.
   [Van Hecke, Lore L.] Global Stem Cell Technol, Noorwegenstr 4, B-9940 Evergem, Belgium.
C3 Ghent University; Ghent University
RP Haspeslagh, M (通讯作者)，Univ Ghent, Fac Vet Med, Dept Surg & Anaesthesiol Domest Anim, Merelbeke, Belgium.
EM maarten.haspeslagh@ugent.be
RI Haspeslagh, Maarten/T-8618-2019; Chiers, Koen/NJS-8348-2025
OI Martens, Ann/0000-0001-9554-4841; Chiers, Koen/0000-0002-7449-1047
FU Special Research Fund, Ghent University [01D25512]
FX Special Research Fund, Ghent University, grant no 01D25512.
CR Adams AP, 1999, VET SURG, V28, P219, DOI 10.1053/jvet.1999.0219
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NR 25
TC 7
Z9 10
U1 2
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0425-1644
EI 2042-3306
J9 EQUINE VET J
JI Equine Vet. J.
PD MAY
PY 2022
VL 54
IS 3
BP 592
EP 600
DI 10.1111/evj.13487
EA JUL 2021
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 0J3SC
UT WOS:000678797500001
PM 34115409
DA 2026-07-24
ER
PT J
AU Burusapat, C
   Sringkarawat, S
AF Burusapat, Chairat
   Sringkarawat, Sophilak
TI Efficacy of Negative-Pressure Wound Therapy with
   Tetrachlorodecaoxygen-Anion Complex Instillation Compared with Standard
   Negative-Pressure Wound Therapy for Accelerated Wound Healing: A
   Prospective, Randomized, Controlled Trial
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SALINE INSTILLATION; BACTERIAL COUNTS;
   DOUBLE-BLIND; RECOMMENDATIONS; MECHANISM; OUTCOMES; IMPACT; AGENT
AB Background: Negative-pressure wound therapy (NPWT) with instillation is a novel wound therapy. The optimal solution is still being investigated. Tetrachlorodecaoxygen-anion complex (TCDO) causes increased phagocytosis and oxygenation. The authors' objective was to investigate the efficacy of NPWT with TCDO instillation (NPWTi) and to compare the results with NPWT alone.
   Methods: A randomized controlled trial was conducted. Inclusion criteria were wound size greater than 4 cm(2) and depth greater than 10 mm. Exclusion criteria were malignancy, immunocompromise, and allergy to TCDO. Patients were randomized into NPWT and NPWTi groups. Outcome measurements consisted of wound surface area, depth, volume, tissue culture, and pathologic evaluation.
   Results: A total of 24 patients in each group were enrolled. The percentages of wound surface area reduction of NPWTi and NPWT groups were 24.1 +/- 6.8 and 28.2 +/- 7.6 on day 12, and 19.0 +/- 6.6 and 22.7 +/- 7.8 on day 15, respectively (p < 0.05). The percentages of wound depth reduction were 16.4 +/- 5.3 and 22.5 +/- 10.5 on day 12, and 12.0 +/- 6.7 and 14.1 +/- 8.0 on day 15, respectively (p < 0.05). The percentages of wound volume reduction were 17.9 +/- 4.6 and 21.6 +/- 5.8 on day 12, and 14.7 +/- 6.0 and 17.1 +/- 6.6 on day 15, respectively (p < 0.05). No statistically significant difference in microbial reduction was found between the groups. Histopathologic examination showed that more angiogenesis was observed in the NPWTi group than in the NPWT group.
   Conclusions: NPWT with TCDO instillation statistically significantly accelerated wound healing, but it did not show significant microbial reduction. The authors' results suggest that TCDO instillation may be an adjunctive treatment in NPWT.
C1 [Burusapat, Chairat] Phramongkutklao Hosp, Div Plast & Reconstruct Surg, Dept Surg, 315 Ratchawithi Rd, Bangkok 10400, Thailand.
   Phramongkutklao Coll Med, Bangkok, Thailand.
C3 Phramongkutklao Hospital; Phramongkutklao College of Medicine
RP Burusapat, C (通讯作者)，Phramongkutklao Hosp, Div Plast & Reconstruct Surg, Dept Surg, 315 Ratchawithi Rd, Bangkok 10400, Thailand.
EM pataranat@hotmail.com
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NR 42
TC 6
Z9 7
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD AUG
PY 2021
VL 148
IS 2
BP 339
EP 352
DI 10.1097/PRS.0000000000008233
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TR4ZQ
UT WOS:000678974600059
PM 34153022
DA 2026-07-24
ER
PT J
AU Sergeenko, MO
   Korostelev, YM
   Shikhaleva, GN
   Savin, MD
   Filatov, YE
   Ryabykh, OS
AF Sergeenko (Pavlova), M. Olga
   Korostelev, Yu. Michail
   Shikhaleva, G. Natalia
   Savin, M. Dmitry
   Filatov, Yu. Egor
   Ryabykh, O. Sergey
TI Negative pressure wound therapy in cases of spinal surgery and exposed
   dura: a case-based review
SO CHILDS NERVOUS SYSTEM
LA English
DT Review
DE Spinal dysraphism; Myelomeningocele; Negative pressure wound therapy;
   Vacuum-assisted closure
ID CEREBELLAR HEMORRHAGE; MYELOMENINGOCELE; CHILDREN; KYPHECTOMY; KYPHOSIS;
   COMPLICATION; IMPROVEMENT; REPAIR; ULCERS
AB Purpose Study of negative pressure wound therapy (NPWT) safety for patients with intraoperative exposure of the dura. Methods We analyzed the literature on the NPWT usage after spinal surgery in patients with exposure of the dura. We also described our experience of NPWT in 3 pediatric patients with spinal dysraphism. Due to the peculiarities of the anatomy (spina bifida), all of these patients had dural sac exposure during spinal surgery. Results The reasons for NPWT in all three cases were different. In the first patient with segmental spinal dysgenesis, surgery was complicated by extensive postoperative wound necrosis and the formation of soft tissue deficiency. The second patient with post-myelomeningocele kyphosis had a deficiency of soft tissues during spinal surgery due to a large bedsore at the apex of the deformity. And in the third patient also with post-myelomeningocele kyphosis, NPWT was applied with surgical site infection. In all three cases, NPWT was used when the dura was exposed, without complications and with satisfactory results. The observation period for the patients was 3 years, 2.5 years, and 2 years, respectively. Conclusions The usage of NPWT in cases of wound complications in the spinal surgery may be a useful option, which allows saving implants. NPWT is not contraindicated in cases of intraoperative dural exposure if there are no signs of cerebrospinal fluid (CSF) leak.
C1 [Sergeenko (Pavlova), M. Olga; Savin, M. Dmitry; Filatov, Yu. Egor; Ryabykh, O. Sergey] Ilizarov Ctr, Div Spinal Surg, 6 M Ulyanova St, Kurgan 640014, Russia.
   [Korostelev, Yu. Michail; Shikhaleva, G. Natalia] Ilizarov Ctr, Div Plast Surg & Reconstruct, Kurgan, Russia.
C3 Ilizarov National Scientific Center for Restorative Traumatology &
   Orthopaedics; Ilizarov National Scientific Center for Restorative
   Traumatology & Orthopaedics
RP Sergeenko, MO (通讯作者)，Ilizarov Ctr, Div Spinal Surg, 6 M Ulyanova St, Kurgan 640014, Russia.
EM pavlova.neuro@mail.ru; savindm81@mail.ru; filatov@ro.ru
RI Ryabykh, Sergey/I-4554-2018; /N-9689-2018; /O-3108-2018
OI Ryabykh, Sergey/0000-0002-8293-0521; 
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NR 32
TC 3
Z9 5
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0256-7040
EI 1433-0350
J9 CHILD NERV SYST
JI Childs Nerv. Syst.
PD OCT
PY 2021
VL 37
IS 10
BP 2975
EP 2981
DI 10.1007/s00381-021-05302-9
EA JUL 2021
PG 7
WC Clinical Neurology; Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pediatrics; Surgery
GA WG1YZ
UT WOS:000679008300001
PM 34312707
DA 2026-07-24
ER
PT J
AU Stroder, M
   Litt, JS
   Litofsky, NS
AF Stroder, Madelyn
   Litt, Jeffrey S.
   Litofsky, N. Scott
TI Complex Multidisciplinary Cranial and Scalp Reconstruction for Patient
   Salvage
SO WORLD NEUROSURGERY
LA English
DT Article
DE Complex; Cranial; Dermal regeneration template; Multidisciplinary;
   Reconstruction; Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; DERMAL REGENERATION TEMPLATE; WOUNDS; FLAP;
   MANAGEMENT; THERAPY; CALVARIA; HEAD; DURA; SKIN
AB OBJECTIVE/BACKGROUND: Patients can develop scalp and cranial defects as a result of neoplasm, trauma, or infection. Reconstruction of these defects can be difficult in some patients and may require a multidisciplinary approach using creative solutions usually used for disease processes in other areas of the body, such as severe burns. -METHODS: A series of 9 patients were treated using multidisciplinary techniques for reconstruction of complex cranial and scalp defects. Data on patient characteristics, initial treatment, and preparatory and definitive reconstructive treatment were retrospectively collected. Outcomes were measured as full solution, partial solution, or failure. -RESULTS: Three patients had a full solution/wound closure, 5 had a partial solution, and 1 failed reconstructive attempt. Full solution patients tended to be younger, received reconstruction treatment modalities for longer periods of time, and had more definitive surgeries. Initial and preparatory surgeries did not tend to promote a full solution, though having fewer preparatory surgeries that were not related to wound vacuum-assisted closure use tended to be associated with a better outcome. Infection of the scalp or cranium did not tend to change the result. -CONCLUSIONS: Reconstructive salvage of complex cranial and scalp defects takes time, so patience and earlier recognition of need for atypical reconstruction is beneficial. Patient characteristics may influence outcomes, but judicious choice of materials and techniques is more critical to patient success. Use of a multidisciplinary approach to complex cranial and scalp reconstruction is a beneficial option for many patients for whom standard reconstruction methods are not viable.
C1 [Stroder, Madelyn; Litofsky, N. Scott] Univ Missouri, Sch Med, Div Neurol Surg, One Hosp Dr, Columbia, MO 65211 USA.
   [Litt, Jeffrey S.] Univ Missouri, Div Acute Care Surg, Sch Med, One Hosp Dr, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Litofsky, NS (通讯作者)，Univ Missouri, Sch Med, Div Neurol Surg, One Hosp Dr, Columbia, MO 65211 USA.
EM litofskyn@health.missouri.edu
RI ; Litofsky, N. Scott/AEU-0703-2022
OI Stroder, Madelyn/0000-0003-1854-2791; Litofsky, N.
   Scott/0000-0001-6373-7462
FU University of Missouri School of Medicine in 2020
FX M. Stroder received a Summer Research Fellowship from University of
   Missouri School of Medicine in 2020 to conduct this research project.
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NR 39
TC 6
Z9 6
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD AUG
PY 2021
VL 152
BP E549
EP E557
DI 10.1016/j.wneu.2021.06.041
EA JUL 2021
PG 9
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA TS1ZH
UT WOS:000679455500024
PM 34144172
DA 2026-07-24
ER
PT J
AU Monteiro, LH
   Da Silva, SKSM
   Benarrós, MSC
   Lopes, CTD
   Domingues, SFS
AF Monteiro, Louysse Helene
   Souza Marques Da Silva, Sandy Kelly
   Camara Benarros, Marina Sette
   De Albuquerque Lopes, Cinthia Tavora
   Souza Domingues, Sheyla Farhayldes
TI Use of Cost-effective Vacuum-assisted Closure Technique for Shell
   Fracture Repair and Coelomic Cavity Rupture Healing in a Chelonia
   carbonaria
SO ACTA SCIENTIAE VETERINARIAE
LA Portuguese
DT Article
DE Chelonoidis carbonaria; run over; vacuum-assisted therapy; shell repair;
   dental resin
AB Background: The vacuum-assisted closure (VAC) therapy system has been used as a noninvasive wound management technique for shell damage in Chelonians. These animals are excellent candidates for VAC therapy because of their unique shell anatomy consists of dermal bones, which make bandage placement easier. Beyond that, they are suited for this technique behaviorally, because they are not inclined to remove the vacuum system intentionally. Considering the possibility of Testudines shell repair with the use of less invasive techniques, that result no additional dermal bone lesions, the objective of the present study is to describe the adaptation of a vacuum dressing protocol using low-cost and easily accessible materials for post-traumatic shell healing of a specimen of Chelonoidis carbonaria.
   Case: A specimen of tortoise (Chelonoidis carbonaria), a male, weighing 630 g, approximately 3-year-old, was received at the Veterinary Hospital - Wild Animals Sector in the Federal University of Para (UFPA) after of being run over by a vehicle. On physical examination, fractures of the dermal plaques and underlying bone structures were found, with rupture of the coelomic cavity. In addition, there was exposure and incarceration of an intestinal loop, with the presence of bleeding. According to the findings of the physical screening examination, the patient's prognosis was defined as good, as described in the literature that specifically focused on chelonian shell injuries. The animal was sent to the diagnostic imaging sector. Then, drug therapy was provided for pain control, vitamins were administered for nutritional support, and antibiotics and anti-inflammatory drugs were instituted. For the closure of the shell and coelomic cavity, a bandage was used with the VAC therapy system adapted as described for Chelonians in previous reports. After a complete osteosynthesis and closure of the coelomic cavity, repair of the integumentary component of the shell was possible. For this procedure, the animal did not need to be anesthetized. The patient was physically restrained by being placed in suspension on a support with a diameter smaller than the plastron. Complete asepsis of the shell was necessary. On top of the lesion, a polypropylene mesh and color less dental resin were applied. The animal continued to be evaluated after the repair to check for potential complications. This procedure ensured that the repaired plates remained stable. Furthermore, the animal did not seem to have any discomfort with the resin when moving, so the animal was discharged after 25 days of hospitalization.
   Discussion: Radiography was important to determine the condition of the animal and clinical prognosis, and thus, to perform the proper treatment. The VAC therapy system was successful in assisting the patient's recovery. It enabled the reduction of the healing time since shell injuries usually require four to eighteen months to heal. In this report, the healing process only required 17 days, demonstrating that the VAC therapy system is a beneficial treatment to treat traumatic injuries in Testudines. The restoration protocol of the integumentary component using dental resin is less invasive, and this type of material has been used previously by other authors. Drug treatment with aminoglycosides and sulphonamides administered prophylactically has proven to be effective and has been used successfully in reptiles. These drugs may be combined with maintenance fluid therapy to prevent adverse reactions from aminoglycosides, such as nephrotoxicity. It was concluded that the use of the VAC therapy system reduced the time of post-traumatic healing of the carapace and proved to be an innovative approach to treat traumatic injuries in Testudines in a less invasive way.
C1 [Monteiro, Louysse Helene; Souza Marques Da Silva, Sandy Kelly] Univ Fed Para UFPA, Posgrad Saude Anim Amazonia PPGSAAM, Inst Med Vet IMV, Castanhal, PA, Brazil.
   [De Albuquerque Lopes, Cinthia Tavora; Souza Domingues, Sheyla Farhayldes] Univ Fed Para UFPA, Hosp Vet Setor Anim Silvestres HVSAS, Castanhal, PA, Brazil.
   [Camara Benarros, Marina Sette] Univ Fed Tocantins UFT, Programa Posgrad Sanidade Anim & Saude Publ Trop, Araguaina, TO, Brazil.
C3 Universidade Federal do Para; Universidade Federal do Para; Universidade
   Federal do Tocantins (UFT)
RP Monteiro, LH (通讯作者)，UFPA, PPGSAAM, Campus Castanhal,Br 316,Km 61, Castanhal, PA, Brazil.
EM helenelouysse@gmail.com
RI Souza Marques da Silva, Sandy Kelly/OTI-4324-2025; Souza Domingues,
   Sheyla Farhayldes/C-4406-2013
OI Souza Marques da Silva, Sandy Kelly/0000-0002-1326-1125; Souza
   Domingues, Sheyla Farhayldes/0000-0002-6017-7647; Monteiro, Louysse
   Helene/0000-0002-7845-3662; Benarrós, Marina/0000-0003-0680-5478
CR Adkesson MJ, 2007, JAVMA-J AM VET MED A, V231, P1249, DOI 10.2460/javma.231.8.1249
   Carpenter J.W., 2013, EXOTIC ANIMAL FORMUL, V5th, P127
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NR 15
TC 0
Z9 0
U1 1
U2 5
PU UNIV FED RIO GRANDE DO SUL
PI PORTO ALEGRE RS
PA FAC VET, CAIXA POSTAL 15017, PORTO ALEGRE RS, 91501-570, BRAZIL
SN 1678-0345
EI 1679-9216
J9 ACTA SCI VET
JI Acta Sci. Vet.
PY 2021
VL 49
SU 1
AR 623
DI 10.22456/1679-9216.104476
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA TU0PV
UT WOS:000680744800034
OA gold
DA 2026-07-24
ER
PT J
AU Ehya, REM
   Zhang, H
   Qi, BW
   Yu, AX
AF Ehya, Regis Ernest Mendame
   Zhang, Hao
   Qi, Baiwen
   Yu, Aixi
TI Application and Clinical Effectiveness of Antibiotic-Loaded Bone Cement
   to Promote Soft Tissue Granulation in the Treatment of Neuropathic
   Diabetic Foot Ulcers Complicated by Osteomyelitis: A Randomized
   Controlled Trial
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID VACUUM SEALING DRAINAGE; HEALING TIMES; INFECTION; KNEE; THERAPY;
   ARTHROPLASTY; AMPUTATIONS; PREVENTION; MANAGEMENT; CHILDREN
AB This study explored the clinical effectiveness of antibiotic-loaded bone cement on primary treatment of diabetic foot infection. This is a randomized controlled study, including thirty-six patients with diabetic foot ulcer complicated by osteomyelitis who had undergone treatment between May 2018 and December 2019. Patients were randomly divided into control group (group A) and study group (group B). Patients in the intervention group received antibiotic-loaded bone cement repair as primary treatment, while patients in the control group received conventional vacuum sealing draining treatment. Clinical endpoints were assessed and compared between the two groups, including wound healing time, wound bacterial conversion, NRS pain score, number of wound dressing changes, and average hospitalization time. All patients were followed up for a period of 12 months after discharge. Results show that compared with the control group, patients in the study group had significant difference in the number of patients for baseline pathogens eradication, short NRS pain score, hospital length of stay and cost, wound surface reduction, healing time, low rate of complications, and infection recurrence. Based on the findings, we conclude that antibiotic-loaded bone cement can be used for treatment of wound in patient with diabetic foot infection. It can help to control wound infections, shorten hospital length of stay, reduce medical cost, and relieve both doctors' and patients' burden. The application of antibiotic-loaded bone cement is suitable for diabetic wound with soft tissue infection or osteomyelitis.
C1 [Ehya, Regis Ernest Mendame; Zhang, Hao; Qi, Baiwen; Yu, Aixi] Wuhan Univ, Dept Orthoped Trauma & Microsurg, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Qi, BW; Yu, AX (通讯作者)，Wuhan Univ, Dept Orthoped Trauma & Microsurg, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
EM qbw2004@sina.com; yuaixi666@163.com
OI Mendame ehya, Regis ernest/0000-0003-3275-6649
CR [Anonymous], 2017, IDF Diabetes Atlas, V8th
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NR 57
TC 30
Z9 33
U1 1
U2 30
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD JUL 14
PY 2021
VL 2021
AR 9911072
DI 10.1155/2021/9911072
PG 12
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA TU1ZB
UT WOS:000680837900002
PM 34337074
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Engel, R
   Greenberg, Y
   Siddiqui, A
AF Engel, Ricardo
   Greenberg, Yitzchok
   Siddiqui, Aamir
TI Negative Pressure Wound Therapy for Improved Nipple Survival in Large
   Volume Reduction Mammaplasty
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; npwt; Breast reduction; Mammaplasty;
   Macromastia; Gigantomastia; Nipple ischemia; Nipple necrosis
ID BREAST REDUCTION; GRAFT; COMPLICATIONS; SENSATION; SUPERIOR
AB Background Large volume breast reductions are at increased risk of nipple ischemia and necrosis due to tenuous blood supply of long pedicles. We adapted incisional negative pressure wound therapy to augment nipple survival in such patients undergoing mammaplasty by inferior pedicle technique.
   Methods Patients with nipple-to-inframammary fold distance > 14 cm were informed of increased risk of requiring free nipple graft. All patients underwent inferior pedicle technique with Wise pattern skin incision. Once incisions were closed and the nipple-areolar complex was inset, the complex was assessed for vascularity. In 12 cases there was evidence of compromised arterial inflow or venous outflow. For these patients, incisional negative pressure wound therapy was applied to the bilateral nipple-areolar complexes for 5-7 days.
   Results None of the 12 patients (24 breasts) in this series experienced nipple-areolar complex ischemia or necrosis. Only 2 patients experienced delayed wound healing which was successfully managed by local wound care.
   Conclusions This study demonstrates the utility of negative pressure wound therapy in nipple survival for at-risk patients. We believe it augments healing by allowing improved micro-circulation.
C1 [Engel, Ricardo] Wayne State Univ, Sch Med, 540 E Canfield, Detroit, MI 48201 USA.
   [Greenberg, Yitzchok; Siddiqui, Aamir] Henry Ford Hlth Syst, Detroit, MI USA.
C3 Wayne State University; Henry Ford Health System; Henry Ford Hospital
RP Engel, R (通讯作者)，Wayne State Univ, Sch Med, 540 E Canfield, Detroit, MI 48201 USA.
EM ricardo.engel@med.wayne.edu
RI siddiqui, aamir/B-1708-2009
OI Engel, Ricardo/0000-0002-7184-7714
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NR 23
TC 6
Z9 8
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD FEB
PY 2022
VL 46
IS 1
BP 108
EP 112
DI 10.1007/s00266-021-02492-0
EA AUG 2021
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA YX3GN
UT WOS:000681528000003
PM 34355263
DA 2026-07-24
ER
PT J
AU Beckmann, NA
   Hanslmeier, MG
   Omlor, GW
   Feisst, M
   Maier, MW
   Lehner, B
AF Beckmann, Nicholas A.
   Hanslmeier, Maximilian G.
   Omlor, Georg W.
   Feisst, Manuel
   Maier, Michael W.
   Lehner, Burkhard
TI Is Negative Pressure Wound Therapy with Instillation Suitable for the
   Treatment of Acute Periprosthetic Hip Joint Infection?
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE hip; joint infection; prosthesis; arthroplasty; DAIR; debridement and
   implant retention; NPWTI; THA; negative pressure wound therapy
ID TOTAL KNEE ARTHROPLASTY; IMPLANT RETENTION; PROSTHESIS RETENTION;
   BACTERIAL BIOFILMS; FAILED IRRIGATION; DEBRIDEMENT; OUTCOMES;
   ANTIBIOTICS; REPLACEMENT; MANAGEMENT
AB Background: Periprosthetic joint infection (PJI) can be devastating for the patient and demanding for the surgeon. In acute PJI, attempts are made to retain the prosthesis by debridement of the infected tissue, targeted antibiotic therapy and an exchange of modular components with implant retention (DAIR). There has been sparse research with adjunctive negative pressure wound treatment with wound irrigation (NPWTI) on the treatment outcome. Questions/purposes: The goal was to assess the efficacy of our protocol of DAIR with adjunctive NPWTI in acute PJI and to reduce the need for later additional DAIR and Irrigation and Debridement (I and D). Patients and Methods: Our cohort of 30 patients (31 hips) with acute PJI was divided into two groups based on symptom presentation up to 6 weeks or >6 weeks from prior (index) surgery (acute early or acute late groups, respectively). All received DAIR with an exchange of modular components and NPWTI with polyhexanide instillation, with the goal of bacterial elimination and biofilm elimination. Postoperatively, the patients were followed up clinically and radiographically for a mean of 4.3 years. Results: Of the 31 PJI hips, 19 were early acute and 12 were late acute. In total, 21 hips had no evidence of residual infection, 10 required further surgical revision: 1 due to dislocation and 9 due to infection. Of these nine, seven had a removal of all the components and two were treated with irrigation and debridement (I and D), with the demise of one patient from pneumonia shortly after the procedure. The Kaplan-Meier 60-month revision free implant survival from infection was 73.2% (CI: 58.9-91.0%) and at the final follow up, the mean Harris Hip Score (HHS) was 81.1 +/- 11.8 and the mean WOMAC score was 33.3 +/- 20.1. Conclusions: Our results are in line with those reported in prior studies. However, the utility of our protocol is inconclusive and needs further evaluation based on our small cohort and the lack of a control group. Level of Evidence: IV.
C1 [Beckmann, Nicholas A.; Hanslmeier, Maximilian G.; Omlor, Georg W.; Lehner, Burkhard] Univ Hosp Heidelberg, Dept Orthopaed & Trauma Surg, Schlierbacher Landstr 200A, D-69118 Heidelberg, Germany.
   [Feisst, Manuel] Univ Hosp Heidelberg, Inst Med Biometr & Informat, Neuenheimer Feld 130-3, D-69120 Heidelberg, Germany.
   [Maier, Michael W.] Swabian Joint Ctr, Christoph Str 7, D-70178 Stuttgart, Germany.
C3 Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg
RP Beckmann, NA (通讯作者)，Univ Hosp Heidelberg, Dept Orthopaed & Trauma Surg, Schlierbacher Landstr 200A, D-69118 Heidelberg, Germany.
EM nicholas.beckmann@med.uni-heidelberg.de;
   Maximilian.Hanslmeier@med.uni-heidelberg.de;
   Georg.Omlor@med.uni-heidelberg.de; feisst@imbi.uni-heidelberg.de;
   maier@sgz-stuttgart.de; burkhard.lehner@med.uni-heidelberg.de
RI Beckmann, Nicholas/IYT-0829-2023
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NR 72
TC 6
Z9 8
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2021
VL 10
IS 15
AR 3246
DI 10.3390/jcm10153246
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TW0FI
UT WOS:000682087100001
PM 34362030
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Maus, JC
   Hemal, K
   Khan, M
   Calder, BW
   Marks, MW
   Defranzo, AJ
   Pestana, IA
AF Maus, Jacob C.
   Hemal, Kshipra
   Khan, Mija
   Calder, Bennett W.
   Marks, Malcolm W.
   Defranzo, Anthony J.
   Pestana, Ivo Alexander
TI Dermal Regeneration Template and Staged Skin Grafting for Extirpative
   Scalp Wound Reconstruction: A 14-Year Experience
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article
DE scalp reconstruction; scalp cancer reconstruction; Integra; cancer;
   scalp; dermal regeneration template; scalp; cranial burring; outer-table
   craniectomy; negative pressure wound therapy; scalp; periosteum; skin
   graft
ID ARTIFICIAL DERMIS; FREE FLAPS; DEFECTS; COMPLICATIONS; COVERAGE
AB Objective Dermal regeneration template and staged split-thickness skin grafting may mitigate the need for flap coverage of postoncologic scalp defects. This technique has been studied previously in small case series. We examine the effect of risk factors, surgical technique, irradiation, and dressing modalities on reconstructive outcomes in a highly comorbid patient cohort. Study Design Retrospective review. Setting Academic medical center. Methods Full- and partial-thickness extirpative scalp wounds reconstructed with dermal regeneration template and staged skin grafting were reviewed over a 14-year period. Stage 1 consisted of template application following burr craniectomy in cases lacking periosteum. Stage 2 consisted of skin grafting. Negative pressure wound therapy (NPWT) was variably used to support adherence. Results In total, 102 patients were analyzed (average age 74, mean follow-up 18 months). Eighty-one percent were American Society of Anesthesiologists class 3 or 4. Defect size averaged 56 cm(2). Average skin graft take was 94.5% in full-thickness wounds. Seven patients failed this method. Preoperative scalp irradiation was associated with major complication and delayed graft healing. Comorbidities, wound size, and burring were not associated with complication. Patients were more likely to heal with NPWT compared to bolster (hazard ratio, 1.67; 95% CI 1.01-2.77; P = .046). Time between stages was 6.6 days shorter when NPWT was applied (P < .001). Conclusion Dermal template and staged skin grafting is a reliable option for postcancer scalp reconstruction in poor flap candidates. Radiotherapy is associated with adverse outcomes. Negative pressure wound therapy simplifies postoperative wound care regimens and may accelerate healing.
C1 [Maus, Jacob C.; Khan, Mija; Calder, Bennett W.; Marks, Malcolm W.; Defranzo, Anthony J.; Pestana, Ivo Alexander] Wake Forest Baptist Med Ctr, Dept Plast & Reconstruct Surg, One Med Ctr Blvd, Winston Salem, NC 27157 USA.
   [Hemal, Kshipra] Wake Forest Sch Med, Winston Salem, NC 27101 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University
RP Pestana, IA (通讯作者)，Wake Forest Baptist Med Ctr, Dept Plast & Reconstruct Surg, One Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM ipestana@wakehealth.edu
RI Pestana, Ivo Alexander/JMR-2324-2023
OI Pestana, Ivo Alexander/0000-0001-6272-4213
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NR 22
TC 9
Z9 9
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD AUG
PY 2021
VL 165
IS 2
BP 275
EP 281
AR 0194599820986582
DI 10.1177/0194599820986582
EA FEB 2021
PG 7
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA TY5PT
UT WOS:000682551400001
PM 33588623
DA 2026-07-24
ER
PT J
AU Oh, BH
   Park, YY
   Park, JK
   Park, YS
AF Oh, Byeong Ho
   Park, Yoon Young
   Park, Ji Kang
   Park, Young Seok
TI Vacuum-Assisted Closure with Temporalis Muscle Reconstruction for
   Recurrent Scalp Erosion Following Deep Brain Stimulation: A Case Report
SO JOURNAL OF PARKINSONS DISEASE
LA English
DT Article
DE DBS; scalp erosion; vacuum-assisted closure
ID HARDWARE-RELATED COMPLICATIONS; SHAPED SKIN INCISION; THERAPY; FLAP
AB Background: Scalp erosion is not an uncommon complication of deep brain stimulation (DBS) surgery. Although various methods have been proposed to prevent and manage complications, there are still challenges. We introduce a case of recurrent scalp erosion after DBS surgery treated with vacuum-assisted closure.
   Case description: This article reports the case of a patient who underwent DBS for advanced Parkinson's disease and suffered from recurrent scalp erosion with device extrusion through the skin. Scalp erosion occurred 2 years after DBS and repeated improvement and deterioration despite scalp reconstruction using a skin flap. We opened the wound and performed temporal muscle reconstruction to cover the burr hole site, and we changed the exposed cable and applied vacuum-assisted closure. During the follow-up period, no signs of erosion or infection occurred, and DBS efficacy was preserved.
   Conclusion: To date, the available management strategies for scalp erosion after DBS are revision with debridement and scalp reconstruction using skin flaps or skin grafts. However, if erosion occurs repeatedly despite the above management strategies, vacuum-assisted closure with temporalis muscle reconstruction could be a suitable option. We suggest that if the condition of the scalp is weakened, it is worth considering this approach preferentially.
C1 [Oh, Byeong Ho; Park, Yoon Young; Park, Young Seok] Chungbuk Natl Univ, Coll Med, Grad Sch, Dept Neurosci, Cheongju, South Korea.
   [Oh, Byeong Ho; Park, Yoon Young; Park, Young Seok] Chungbuk Natl Univ Hosp, Dept Neurosurg, Cheongju, South Korea.
   [Park, Ji Kang] Chungbuk Natl Univ Hosp, Dept Orthoped Surg, Cheongju, South Korea.
   [Park, Young Seok] Chungbuk Natl Univ Hosp, Gamma Knife Icon Ctr, Dept Neurosurg, Cheongju, South Korea.
   [Park, Young Seok] Chungbuk Natl Univ, Inst Stem Cell & Regenerat Med ISCRM, Cheongju, South Korea.
C3 Chungbuk National University; Chungbuk National University; Chungbuk
   National University Hospital; Chungbuk National University; Chungbuk
   National University Hospital; Chungbuk National University; Chungbuk
   National University Hospital; Chungbuk National University
RP Park, YS (通讯作者)，Chungbuk Natl Univ, Coll Med, NeuroFuture Lab, Chungbuk Natl Univ Hosp,Dept Neurosurg, 776,1 Sunhwan Ro, Cheongju 28644, South Korea.
EM youngseokparkmd@gmail.com
FU Chungbuk National University Korea National University Development
   Project
FX This research was supported by Chungbuk National University Korea
   National University Development Project (2020)
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NR 25
TC 0
Z9 0
U1 0
U2 1
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1877-7171
EI 1877-718X
J9 J PARKINSON DIS
JI J. Parkinsons Dis.
PY 2021
VL 11
IS 3
BP 1465
EP 1469
DI 10.3233/JPD-212651
PG 5
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA TX3ZH
UT WOS:000683027900045
PM 33843699
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Wang, LC
   Wang, CR
   Chen, HM
   Chen, Y
   Li, J
   Xiao, L
   Zhu, D
   Yang, CZ
AF Wang, Liangchen
   Wang, Chenrui
   Chen, Hongmei
   Chen, Ying
   Li, Juan
   Xiao, Li
   Zhu, Di
   Yang, Caizhe
TI The Combined Use of a Non-Invasive Skin-Stretching Device and the
   Negative-Pressure Wound Therapy Technique in the Treatment of
   Postoperative Diabetic Foot
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE diabetic foot; negative-pressure wound therapy; wound healing;
   skin-stretching device
ID ULCERS; CLOSURE; SYSTEM; SECURE
AB Objective: The present study explored the effectiveness of using a non-invasive skin-stretching device (NSSD) combined with negative-pressure wound therapy (NPWT) for the postoperative wound repair of diabetic foot (DF) gangrene.
   Methods: The treatment group in this study involved 42 patients with Wagner grade 3-4 DF and undergone concomitant toe amputation or debridement, who were given NPWT combined with the use of a NSSD. The control group comprised 42 patients with similar trauma areas (+/- 20%) that were matched at a ratio of 1:1. Following surgery, these patients received NPWT combined with the use of conventional dressings. A comparison was made of the postoperative wound healing rates and wound healing times of the two groups, with Kaplan-Meier survival analysis being used to compare the healing rate over time.
   Results: The three-month wound healing rate was higher in the treatment group than in the control group (38 of 42 [90.5%] vs 25 of 42 [59.5%], p = 0.002), and the wound healing time was shorter in the treatment group (44 days [95% CI 40.0-48.0]) than that in the control group (76 days [95% CI 63.0-89.0], p = 0.000). Taking the end of the final NPWT as the starting point, the comparison of wound healing time revealed that this period was shorter in the treatment group than that in the control group and the difference was statistically significant (11 days [95% CI 9.0-13.0] vs 42 days [95% CI 23.0-ND], p = 0.000).
   Conclusion: The use of the NPWT technique combined with a NSSD can shorten the wound healing time and improve the wound healing rate of DF gangrene patients during the postoperative wound repair period.
C1 [Wang, Liangchen; Wang, Chenrui; Chen, Hongmei; Chen, Ying; Li, Juan; Xiao, Li; Zhu, Di; Yang, Caizhe] PLA, Air Force Med Ctr, Dept Endocrinol, Beijing 100142, Peoples R China.
RP Yang, CZ (通讯作者)，PLA, Air Force Med Ctr, Dept Endocrinol, Beijing 100142, Peoples R China.
EM caizheyang06@outlook.com
OI Zhu, Di/0000-0001-8046-0709
FU Beijing Municipal Science and Technology Project: 2018 Clinical
   characteristics and Application Research of Capital [Z181100001718025];
   PLA Youth Training Project for Medical Science [15QNP040]
FX Beijing Municipal Science and Technology Project: 2018 Clinical
   characteristics and Application Research of Capital. (Z181100001718025)
   .PLA Youth Training Project for Medical Science (15QNP040) .
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NR 27
TC 4
Z9 4
U1 0
U2 14
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 3523
EP 3532
DI 10.2147/DMSO.S322757
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TY0KX
UT WOS:000683474300005
PM 34385827
OA Green Accepted, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Shatnawi, NJ
   Al-Zoubi, NA
   Al-Bakkar, LA
   Gharaibeh, LM
   Hamouri, S
AF Shatnawi, Nawaf J.
   Al-Zoubi, Nabil A.
   Al-Bakkar, Lujain A.
   Gharaibeh, Laith M.
   Hamouri, Shadi
TI Nonhealing Leg Ulcer as the Presentation of Sarcoidosis: A Case Report
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE pyoderma gangrenosum; ulcerative sarcoidosis; leg ulcer
ID TUNING FORK; RELIABILITY; NEUROPATHY; DEVICE
AB Chronic leg ulcers (CLUs) are common, with increasing prevalence in the elderly population. Circulatory dysfunctions are responsible for 90% to 95% of all causes, while 5% to 10% of CLUs are associated with underlying chronic systemic disorders. Sarcoidosis is a complex multisystemic disease characterized by noncaseating granulomas affecting mainly the pulmonary system, with cutaneous manifestation in 25% to 30% of cases. However, ulcerative sarcoidosis (US) is a rare form of cutaneous sarcoidosis. Pyoderma gangrenosum (PG) is an uncommon, chronic inflammatory noninfectious skin disease affecting different body parts. The ulcerative form of PG is rarely reported in association with sarcoidosis. We aim to report a 44-year-old female patient with a history of hypertension and varicose veins, presenting with a CLU for more than 18 months. Ulcer tissue biopsy showed noncaseating granuloma with abscess formation suggestive of sarcoidosis; however, PG could not be ruled out. Mediastinal lymph node biopsy was consistent with sarcoidosis. The leg ulcer had complete healing within 4 months by local wound management, negative pressure wound therapy, and split-thickness skin grafting without immunosuppressive treatment to achieve wound healing.
C1 [Shatnawi, Nawaf J.; Al-Zoubi, Nabil A.; Al-Bakkar, Lujain A.; Gharaibeh, Laith M.; Hamouri, Shadi] Jordan Univ Sci & Technol, Irbid, Jordan.
C3 Jordan University of Science & Technology
RP Shatnawi, NJ (通讯作者)，Jordan Univ Sci & Technol, Dept Gen Surg & Urol, POB 3030, Irbid 22110, Jordan.
EM nshatnawi@yahoo.com
RI ; Hamouri, Shadi/AAM-9465-2021
OI Garibeh, Laith/0000-0002-4202-695X; Bakkar, Lujain/0000-0001-8093-0678;
   Hamouri, Shadi/0000-0002-1764-9514
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NR 17
TC 2
Z9 3
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2023
VL 22
IS 4
BP 742
EP 747
AR 15347346211037850
DI 10.1177/15347346211037850
EA AUG 2021
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EY2S2
UT WOS:000683973400001
PM 34374584
DA 2026-07-24
ER
PT J
AU Silverman, RP
   Apostolides, J
   Chatterjee, A
   Dardano, AN
   Fearmonti, RM
   Gabriel, A
   Grant, RT
   Johnson, ON
   Koneru, S
   Kuang, AA
   Moreira, AA
   Sigalove, SR
AF Silverman, Ronald P.
   Apostolides, John
   Chatterjee, Abhishek
   Dardano, Anthony N.
   Fearmonti, Regina M.
   Gabriel, Allen
   Grant, Robert T.
   Johnson, Owen N.
   Koneru, Suresh
   Kuang, Anna A.
   Moreira, Andrea A.
   Sigalove, Steven R.
TI The use of closed incision negative pressure therapy for incision and
   surrounding soft tissue management: Expert panel consensus
   recommendations
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Delphi technique; negative pressure wound therapy; plastic surgery;
   surgical wound; wound healing
ID SURGICAL SITE INFECTION; NIPPLE-SPARING MASTECTOMY; WOUND THERAPY;
   POSTOPERATIVE COMPLICATIONS; METAANALYSIS; SURGERY; PREVENTION; RISK;
   RECONSTRUCTION; REDUCTION
AB As the use of closed incision negative pressure therapy (ciNPT) becomes more widespread, dressing designs have evolved to address implementation challenges and meet surgeon demand. While traditional application of ciNPT was limited to the immediate suture line, a novel dressing that covers the incision and additional surrounding tissues has become available. To expand upon previous ciNPT recommendations and provide guidance on this new dressing, an expert panel of plastic surgeons convened to review the current literature, identify challenges to the implementation and sustainability of ciNPT, and use a modified Delphi technique to form a consensus on the appropriate use of ciNPT with full-coverage dressings. After three rounds of collecting expert opinion via the Delphi method, consensus was reached if 80% of the panel agreed upon a statement. This manuscript establishes 10 consensus statements regarding when ciNPT with full-coverage foam dressings should be considered or recommended in the presence of patient or incision risk factors, effective therapeutic settings and duration, precautions for use, and tools and techniques to support application. The panel also discussed areas of interest for future study of ciNPT with full-coverage dressings. High-quality, controlled studies are needed to expand the understanding of the benefits of ciNPT over the incision and surrounding tissues.
C1 [Silverman, Ronald P.] Univ Maryland, Med Ctr, Dept Surg, Baltimore, MD 21201 USA.
   [Silverman, Ronald P.; Kuang, Anna A.] 3M Co, St Paul, MN 55144 USA.
   [Apostolides, John] Defy Plast & Reconstruct Surg, San Diego, CA USA.
   [Chatterjee, Abhishek] Tufts Med Ctr, Dept Surg, Boston, MA 02111 USA.
   [Dardano, Anthony N.] Florida Atlantic Univ, Dept Surg, Charles E Schmidt Coll Med, Boca Raton, FL 33431 USA.
   [Fearmonti, Regina M.] Alon Aesthet Plast Surg, San Antonio, TX USA.
   [Grant, Robert T.] New York Presbyterian Hosp Columbia & Weill Corne, Div Plast & Reconstruct Surg, New York, NY USA.
   [Koneru, Suresh] Adv Concepts Plast Surg, San Antonio, TX USA.
   [Moreira, Andrea A.] Cleveland Clin, Lerner Coll Med, Dept Surg, Cleveland, OH 44106 USA.
   [Sigalove, Steven R.] Scottsdale Ctr Plast Surg, Paradise Valley, AZ USA.
C3 University System of Maryland; University of Maryland Baltimore; 3M;
   Tufts Medical Center; State University System of Florida; Florida
   Atlantic University; Cornell University; Weill Cornell Medicine;
   NewYork-Presbyterian Hospital; University System of Ohio; Case Western
   Reserve University; Cleveland Clinic Foundation
RP Silverman, RP (通讯作者)，Univ MD Surg Associates, 12203 Tullamore Rd,Roundwood Profess Bldg, Lutherville Timonium, MD 21093 USA.
EM rsilverman@mmm.com
RI Gabriel, Allen/AFK-3548-2022; Silverman, Ronald/A-5155-2018
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NR 72
TC 21
Z9 22
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR
PY 2022
VL 19
IS 3
BP 643
EP 655
DI 10.1111/iwj.13662
EA AUG 2021
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ZH2HY
UT WOS:000684160700001
PM 34382335
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yuan, YS
   Ding, XF
   Jing, ZW
   Lu, H
   Yang, K
   Wang, YL
   Xu, HL
AF Yuan, Yusong
   Ding, Xiaofang
   Jing, Zhengwei
   Lu, Hao
   Yang, Kun
   Wang, Yuanli
   Xu, Hailin
TI Modified tibial transverse transport technique for the treatment of
   ischemic diabetic foot ulcer in patients with type 2 diabetes
SO JOURNAL OF ORTHOPAEDIC TRANSLATION
LA English
DT Article
DE Tibia transverse transport; Ischemic diabetic foot ulcer; Type 2
   diabetes; Cohort study
ID PERIPHERAL ARTERY-DISEASE; DEBRIDEMENT; MANAGEMENT; AMPUTATION; NETWORK
AB Background: Ischemic diabetic foot ulcer is one of the terminal complications of diabetes. The high amputation rate, recurrence rate, and treatment cost have caused a huge burden on patients and society. This study designed the modified tibial transverse transport (mTTT) technology to treat diabetic ischemic diabetic foot ulcers in patients with type 2 diabetes and investigated the effectiveness and safety of this technique.
   Methods: This was a retrospective analysis of patients with type 2 diabetes and ischemic diabetic foot ulcers at two hospitals during January 2016-October 2019. These patients underwent mTTT surgery combined with wound debridement and vacuum sealing drainage negative pressure drainage treatment. In-hospital follow-up was performed at 1 month after the operation, while outpatient follow-up was performed at 3, 6, and 12 months after the operation. The ulcer healing time, recurrence rate, major amputation rate, and complications were analysed.
   Results: A total of 201 patients were enrolled in this study, including 107 males and 94 females (mean age: 68.3 +/- 7.1 years). The wounds of all patients healed completely (mean healing time: 4.6 +/- 1.6 months). There was no occurrence of major amputation, recurrence, and treatment-related complications in the patients.
   Conclusion: mTTT can effectively and safely treat ischemic diabetic foot ulcers in patients with type 2 diabetes. This technology is an important part of the ischemic diabetic foot ulcer treatment system and warrants further research.
   The Translational Potential of this Article: This study introduced a new method to treat the ischemic diabetic foot ulcer which was called modified tibial transverse transport. The promising outcomes of patients indicated that this surgical method had great potential for clinical application and was worthy of further clinical research with high evidence level.
C1 [Yuan, Yusong; Lu, Hao; Xu, Hailin] Peking Univ, Peking Univ Peoples Hosp, Dept Trauma & Orthopaed, Beijing, Peoples R China.
   [Yuan, Yusong; Lu, Hao; Xu, Hailin] Peking Univ, Peking Univ Peoples Hosp, Diabet Foot Treatment Ctr, Beijing, Peoples R China.
   [Yuan, Yusong] Peking Univ, Minist Educ, Key Lab Trauma & Neural Regenerat, Beijing, Peoples R China.
   [Ding, Xiaofang; Yang, Kun; Wang, Yuanli] Beijing Longfu Hosp, 18th Art Museum East St, Beijing, Peoples R China.
   [Jing, Zhengwei] Peking Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Beijing, Peoples R China.
   [Yuan, Yusong; Lu, Hao; Xu, Hailin] Natl Ctr Trauma Med, Beijing, Peoples R China.
C3 Peking University; Peking University; Peking University; Peking
   University
RP Wang, YL (通讯作者)，Beijing Longfu Hosp, 18th Art Museum East St, Beijing, Peoples R China.; Xu, HL (通讯作者)，Peking Univ, Peking Univ Peoples Hosp, Diabet Foot Treatment Ctr, Dept Trauma & Orthopaed, 11th Xizhimen South St, Beijing, Peoples R China.
EM 13797757@qq.com; xuhailinfa@163.com
OI Xu, Hailin/0000-0003-1829-3852
FU Capital's Funds for Health Improvement and Research [2020-2-4086];
   Beijing Municipal Science and Technology Project [Z181100001718159];
   Pilot project on clinical collaboration of major and difficult diseases
   of Chinese and Western medicine [201803190106]; Health Science and
   Technology Project of Beijing Dongcheng District Health Commission
   [[2018]-13]; Key Laboratory of Trauma and Neural Regeneration (Peking
   University), Ministry of Education [BMU2019XY007-01]; Ministry of
   Education Innovation Program of China [IRT_16R01]
FX This study was supported by the Capital's Funds for Health Improvement
   and Research (Grant No. 202024086) ; Beijing Municipal Science and
   Technology Project (Grant No. Z181100001718159) ; Pilot project on
   clinical collaboration of major and difficult diseases of Chinese and
   Western medicine (Grant No. 201803190106) ; Health Science and
   Technology Project of Beijing Dongcheng District Health Commission
   (Grant No. [2018] 13) ; Key Laboratory of Trauma and Neural
   Regener-ation (Peking University) , Ministry of Education (Grant No.
   BMU2019XY00701) ; and Ministry of Education Innovation Program of China
   (Grant No. IRT_16R01) .
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NR 22
TC 32
Z9 42
U1 2
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2214-031X
J9 J ORTHOP TRANSL
JI J. Orthop. Transl.
PD JUL
PY 2021
VL 29
BP 100
EP 105
DI 10.1016/j.jot.2021.04.006
EA MAY 2021
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA TZ6EE
UT WOS:000684563000013
PM 34136348
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Berner-Hansen, V
   Oma, E
   Willaume, M
   Jensen, KK
AF Berner-Hansen, V.
   Oma, E.
   Willaume, M.
   Jensen, K. K.
TI Prophylactic negative pressure wound therapy after open ventral hernia
   repair: a systematic review and meta-analysis
SO HERNIA
LA English
DT Review
DE iNPWT; Ventral hernia repair; Surgical site occurrences; Surgical site
   infections; Incisional hernia repair; Wound complications
ID ABDOMINAL-WALL RECONSTRUCTION; CLOSED-INCISION; COMPONENT SEPARATION;
   COMPLICATIONS; MANAGEMENT; OUTCOMES; COST
AB Purpose Negative pressure wound therapy on closed incisions (iNPWT) is a wound dressing system developed to promote wound healing and avoid complications after surgical procedures. The effect of iNPWT is well established in various surgical fields, however, the effect on postoperative wound complications after ventral hernia repair remains unknown. The aim of this systematic review and meta-analysis was to investigate the effect of iNPWT on patients undergoing open ventral hernia repair (VHR) compared with conventional wound dressing. Materials and methods This systematic review and meta-analysis followed the PRISMA guidelines. The databases PubMed, Embase, Cochrane Library, Web of science and Cinahl were searched for original studies comparing iNPWT to conventional wound dressing in patients undergoing VHR. The primary outcome was surgical site occurrence (SSO), secondary outcomes included surgical site infection (SSI) and hernia recurrence. Results The literature search identified 373 studies of which 10 were included in the meta-analysis including a total of 1087 patients. Eight studies were retrospective cohort studies, one was a cross-sectional pilot study, and one was a randomized controlled trial. The meta-analysis demonstrated that iNPWT was associated with a decreased risk of SSO (OR 0.27 [0.19, 0.38]; P < 0.001) and SSI (OR 0.32 [0.17, 0.55]; P < 0.001). There was no statistically significant association with the risk of hernia recurrence (OR 0.62 [0.27, 1.43]; P = 0.26). Conclusion Based on the findings of this systematic review and meta-analysis iNPWT following VHR was found to significantly reduce the incidence of SSO and SSI, compared with standard wound dressing. INPWT should be considered for patients undergoing VHR.
C1 [Berner-Hansen, V.; Oma, E.; Willaume, M.; Jensen, K. K.] Bispebjerg Hosp, Ctr Digest Dis, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital; Bispebjerg
   Hospital
RP Berner-Hansen, V (通讯作者)，Bispebjerg Hosp, Ctr Digest Dis, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
EM Victoriaberner@hotmail.com
RI Jensen, Kristian/AAI-6028-2020
OI Berner-Hansen, Victoria/0000-0002-7709-6093; Oma,
   Erling/0000-0003-0273-8992; Kiim, Kristian
   Schaumburg/0000-0003-4212-4936
CR [Anonymous], 2012, Surg Infect (Larchmt), V13 Suppl 1, pS9, DOI 10.1089/sur.2012.9908
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NR 42
TC 15
Z9 17
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD DEC
PY 2021
VL 25
IS 6
BP 1481
EP 1490
DI 10.1007/s10029-021-02485-7
EA AUG 2021
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XC8RX
UT WOS:000684919400002
PM 34392436
DA 2026-07-24
ER
PT J
AU Surek, A
   Bozkurt, MA
   Gemici, E
   Kocatas, A
   Ferahman, S
   Seyhun, C
   Binboga, S
   Alis, H
AF Surek, Ahmet
   Bozkurt, Mehmet A.
   Gemici, Eyup
   Kocatas, Ali
   Ferahman, Sina
   Seyhun, Cemal
   Binboga, Sinan
   Alis, Halil
TI Treatment of Anastomotic Leaks With EndoVac After Low Anterior Resection
   in Colorectal Cancers
SO SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
LA English
DT Article
DE anastamotic leaks; EndoVac system; endoscop
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; THERAPY; SURGERY; EXPERIENCE;
   MANAGEMENT; LEAKAGES; RECTUM
AB Introduction: Endoscopic drainage should preferably be tried unless the abscess caused by the anastomotic leak is generalized and disseminated into the abdominal cavity. The aim of this study was to evaluate the results of patients treated with EndoVac. Patient and Methods: The medical records of patients who underwent low anterior resection and were treated using the EndoVac therapy system due to the detection of an anastomotic leak were retrospectively evaluated. Results: Thirty-three of the patients with detection of anastomotic leaks were treated using EndoVac therapy system. The mean number of application of the EndoVac therapy system was 5.8 (1 to 12) for each patient. Mean duration of hospitalization of the patients was 24.5 (9 to 92) days. Five patients underwent a second operation during the follow-up period after application of the EndoVac therapy system. In our study, the number of patients recovering without the need for additional treatment is 30 (30/33). Our success rate was 90.1%. Conclusions: The EndoVac therapy system is an alternative and helpful system in the treatment of colorectal anastomotic leaks without reoperation needed. It can also prevent permanent stoma.
C1 [Surek, Ahmet; Gemici, Eyup; Ferahman, Sina; Binboga, Sinan] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Bozkurt, Mehmet A.; Kocatas, Ali] Kanuni Sultan Suleyman Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Alis, Halil] Istanbul Aydin Univ, Dept Gen Surg, Istanbul, Turkey.
   [Seyhun, Cemal] Lefkose State Hosp, Nicosia, Cyprus.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital; Istanbul Kanuni
   Sultan Suleyman Training & Research Hospital; Istanbul Aydin University
RP Bozkurt, MA (通讯作者)，Teyfik Saglam St 1-125,Bakirkoy, TR-34000 Istanbul, Turkey.
EM ahmetsurek82@hotmail.com; drsamet81@hotmail.com;
   sinaferahmantr@hotmail.com; seyhuncemal@gmail.com
RI Alış, Halil/AAJ-6721-2020; Ferahman, Sina/ABI-4440-2020; /ABC-5796-2020;
   kocatas, ali/HTR-2934-2023
OI Alış, Halil/0000-0002-8008-2776; Bozkurt, Mehmet
   Abdussamet/0000-0003-3222-9363; 
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NR 24
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1530-4515
EI 1534-4908
J9 SURG LAPARO ENDO PER
JI Surg. Laparosc. Endosc. Pct. Tech.
PD AUG
PY 2021
VL 31
IS 4
BP 492
EP 496
DI 10.1097/SLE.0000000000000908
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UA5UZ
UT WOS:000685228300021
PM 33538549
DA 2026-07-24
ER
PT J
AU Moog, P
   Jensch, M
   Betzl, J
   Bauer, AT
   Cerny, MK
   Schmauss, D
   Kükrek, H
   Erne, H
   Machens, HG
   Megerle, K
AF Moog, Philipp
   Jensch, Maryna
   Betzl, Julia
   Bauer, Anna-Theresa
   Cerny, Michael K.
   Schmauss, Daniel
   Kuekrek, Haydar
   Erne, Holger
   Machens, Hans-Guenther
   Megerle, Kai
TI Bacterial bioburden of wounds: influence of debridement and
   negative-pressure wound therapy (NPWT)
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE bacterial bioburden; bacterial levels; dressing; infection; microbiology
   of wounds; negative-pressure wound therapy; NPWT; ulcer; VAC; VAC
   therapy; VAC therapy bioburden; wound; wound treatment
ID VACUUM-ASSISTED CLOSURE; MICROBIOLOGY; INFECTION; ULCERS
AB Objective: To clarify the role of microbiological swabs in surgical decision-making, we investigated the effect of negative-pressure wound therapy (NPWT) and serial surgical debridement on bacterial bioburden in hard-to-heal wounds and ultimately correlated them with the success of surgical closure.
   Method: All patients were treated with surgical debridement, jet lavage and NPWT before their wounds were finally closed. The treatment effect was assessed by correlating microbiological swabs obtained immediately after intervention with those obtained after removal of the dressings during the following surgical procedures. The result of the last microbiological swab taken before definitive surgical closure was correlated with the requirement for revision surgery.
   Results: We included the results of 704 microbiological swabs from 97 patients in 110 wound localisations in this monocentric, retrospective study. NPWT did not improve bacterial bioburden in 77% of cases and the duration of NPWT did not affect the result. Furthermore, no significant effect of NPWT could be found for either anaerobic (p=0.96) or aerobic bacteria (p=0.43). In contrast, surgical debridement increased bacterial load in approximately 60% of cases. If sterile wound swabs could be obtained at all, it was during the first four surgical debridements in 60% of patients; after that only 10% became sterile.
   Conclusions: Sterile microbiological wound swabs before surgical closure were associated with lower rates of revision surgery, while low or medium bacterial loads did not increase revision rates.
C1 [Moog, Philipp; Jensch, Maryna; Betzl, Julia; Bauer, Anna-Theresa; Cerny, Michael K.; Kuekrek, Haydar; Erne, Holger; Machens, Hans-Guenther; Megerle, Kai] Tech Univ Munich, Dept Plast Surg & Hand Surg, Klinikum Rechts Isar, D-81675 Munich, Germany.
   [Schmauss, Daniel] Osped Reg Lugano, Dept Plast Reconstruct & Aesthet Surg, Lugano, Switzerland.
C3 Technical University of Munich
RP Moog, P (通讯作者)，Tech Univ Munich, Dept Plast Surg & Hand Surg, Klinikum Rechts Isar, D-81675 Munich, Germany.
EM philipp.moog1@mri.tum.de
RI Kuekrek, Haydar/NVM-7556-2025; /ABF-2085-2020
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NR 28
TC 9
Z9 12
U1 0
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2021
VL 30
IS 8
BP 604
EP 611
DI 10.12968/jowc.2021.30.8.604
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA UA5VV
UT WOS:000685230500004
PM 34382852
DA 2026-07-24
ER
PT J
AU Wikkeling, TM
   van ijssel, SA
   van der Laan, MJ
   Zeebregts, CJ
   Saleem, B
AF Wikkeling, Tim M.
   Gijssel, Senne A. van
   Laan, Maarten J. van der
   Zeebregts, Clark J.
   Saleem, Ben R.
TI Treatment of patch infection after carotid endarterectomy: a systematic
   review
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Review
DE stenosis; carotid endarterectomy (CEA); angioplasty; patch infection
ID RANDOMIZED CONTROLLED-TRIALS; ARTERY RECONSTRUCTION; PRIMARY CLOSURE;
   FALSE ANEURYSM; ANGIOPLASTY; PSEUDOANEURYSM; MANAGEMENT; FLAP
AB Carotid endarterectomy (CEA) with patch angioplasty is a widely used method for treating carotid artery stenosis. Patch infections are extremely rare, but the consequences may be serious. The current gold standard for treatment is patch excision and reconstruction with autologous material. However, no consensus has been reached and other options may be valuable as well in certain cases. The objective of this study was to evaluate the various treatment options for carotid patch infection after CEA with patch angioplasty on the basis of their outcomes (reinfection, ischemic stroke, and infection-related mortality). This systematic review was conducted in accordance with the PRISMA statement. The electronic bibliographic databases PubMed, Cochrane, and EMBASE were searched. Case series and case reports were included. Studies in languages other than English were excluded. Patients who developed a post-operative patch infection of CEA with patch angioplasty were included. Angioplasty could be performed with any type of patch. Patch infection needed to be confirmed by clinical presentation in combination with imaging, culture, or during the operation. The primary outcome measures were reinfection, ischemic stroke, and infection-related mortality. Eleven retrospective case series, two prospective case series, and seventeen case reports were included. The study size was 165 patients (mean age 69.7 years, M/F ratio 1.75:1). One hundred and seventy-one patches developed a patch infection after CEA with patch angioplasty and needed treatment. Treatment strategies included conservative treatment (14.0%), endovascular treatment (4.7%), and open surgery (81.4%). Mean follow-up was 34.8 months and extended up to 180 months. Reinfection rate was 4.7%, ischemic stroke rate 5.8%, and infection-related mortality rate 2.3%. No statistical comparison between treatment options could be performed, because of the heterogeneity of the included studies. Autologous material should be the primary choice of treatment if patch infection is diagnosed after CEA with patch angioplasty. In emergency situations, endovascular treatment, carotid ligation, or abscess drainage could be considered. Endovascular treatment and abscess drainage are temporary solutions. After the patient has recovered sufficiently, a more durable treatment i.e., open surgery is advised. Endo vacuum assisted closure (EndoVAC) seems to be promising. Further research is needed to determine the applicability of each treatment option.
C1 [Wikkeling, Tim M.; Gijssel, Senne A. van; Laan, Maarten J. van der; Zeebregts, Clark J.; Saleem, Ben R.] Univ Groningen, Univ Med Ctr Groningen, Div Vasc Surg, Dept Surg, POB 30-001, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen
RP Saleem, B (通讯作者)，Univ Groningen, Univ Med Ctr Groningen, Div Vasc Surg, Dept Surg, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM b.r.saleem@umcg.nl
RI van der Laan, Maarten/AAQ-3353-2021
OI van der Laan, Maarten/0000-0002-3125-1342
CR Aromataris E., 2020, JBI
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NR 40
TC 7
Z9 9
U1 0
U2 1
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD JUL
PY 2021
VL 9
IS 14
AR 1213
DI 10.21037/atm-20-7531
PG 14
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA UA8SS
UT WOS:000685426700018
PM 34430654
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gong, SY
   Yang, J
   Lu, TT
   Tian, HW
   Huang, YX
   Song, SM
   Lei, CN
   Yang, WW
   Yang, KH
   Guo, TK
AF Gong, Shiyi
   Yang, Jia
   Lu, Tingting
   Tian, Hongwei
   Huang, Yunxia
   Song, Shaoming
   Lei, Caining
   Yang, Wenwen
   Yang, Kehu
   Guo, Tiankang
TI Incisional negative pressure wound therapy for clean-contaminated wounds
   in abdominal surgery: a systematic review and meta-analysis of
   randomized controlled trials
SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
DE Negative-pressure wound therapy; surgical site infection;
   clean-contaminated wounds; randomized controlled trials; meta-analysis
ID SURGICAL SITE INFECTION; COMPLICATIONS; PREVENTION; MANAGEMENT;
   LAPAROTOMY; GUIDELINE; IMPACT
AB Objective The role of incisional negative-pressure wound therapy (iNPWT) in preventing surgical site infections (SSIs) in clean-contaminated abdominal wounds is still controversial. This meta-analysis was performed to evaluate whether the use of iNPWT could reduce SSIs and other complications in clean-contaminated abdominal surgery. Methods The authors searched PubMed, EMBASE, Cochrane library, and Web of Science from database inception to 23 January 2021 for randomized controlled trials (RCTs). They assessed the risk of bias using the Cochrane Collaboration risk of bias tool and conducted a meta-analysis using RevMan 5.4. Results Eleven RCTs, including 4112 patients, were analyzed, of which 2057 were treated with iNPWT and 2055 with standard dressings. The SSI rates (OR = 0.76, 95% CI = 0.61-0.94, P = 0.01), in patients undergoing an iNPWT intervention were significantly lower than those in patients receiving standard dressings. There was no statistically significant difference between the rates of incision dehiscence, seroma, and readmission between groups. Conclusions Application of iNPWT for clean-contaminated wounds in abdominal surgery reduced SSI rates but showed similar rates of wound dehiscence, seroma, and readmission compared with standard dressings.
C1 [Gong, Shiyi; Yang, Jia; Lu, Tingting; Tian, Hongwei; Huang, Yunxia; Song, Shaoming; Lei, Caining; Yang, Wenwen; Guo, Tiankang] Gansu Prov Hosp, 204 West Donggang RD, Lanzhou, Gansu, Peoples R China.
   [Gong, Shiyi; Yang, Jia; Huang, Yunxia; Guo, Tiankang] Ningxia Med Univ, Yinchuan, Ningxia, Peoples R China.
   [Gong, Shiyi; Yang, Jia; Lu, Tingting; Huang, Yunxia; Song, Shaoming; Lei, Caining; Yang, Wenwen; Yang, Kehu; Guo, Tiankang] Gansu Prov Hosp, Inst Clin Res & Evidence Based Med, Lanzhou, Gansu, Peoples R China.
   [Gong, Shiyi; Yang, Jia; Lu, Tingting; Song, Shaoming; Lei, Caining; Yang, Wenwen; Yang, Kehu] Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Gansu, Peoples R China.
   [Yang, Kehu] Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Gansu, Peoples R China.
C3 Ningxia Medical University; Lanzhou University
RP Guo, TK (通讯作者)，Gansu Prov Hosp, 204 West Donggang RD, Lanzhou, Gansu, Peoples R China.; Yang, KH (通讯作者)，Lanzhou Univ, Evidence Based Med Ctr, 222 West Donggang RD, Lanzhou 730000, Gansu, Peoples R China.
EM kehuyangebm2006@126.com; tiankangguo2020@163.com
RI Lu, Tingting/GZM-8720-2022; Song, Shaoming/AAW-2857-2021
OI Lu, Tingting/0000-0002-6964-3237; Yang, Hehu/0000-0001-7864-3012
FU Key Laboratory of Evidence-Based Medicine and Knowledge Translation
   Foundation of Gansu Province [GSEBMKT-2021KFJJ001]; Gansu Provincial Key
   Laboratory of Molecular Diagnosis and Precision Therapy of Surgical
   Tumors [2019GSZDSYS06]
FX This study was supported by the Key Laboratory of Evidence-Based
   Medicine and Knowledge Translation Foundation of Gansu Province (Grant
   No. GSEBMKT-2021KFJJ001). Gansu Provincial Key Laboratory of Molecular
   Diagnosis and Precision Therapy of Surgical Tumors (Grant No.
   2019GSZDSYS06).
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NR 39
TC 4
Z9 4
U1 1
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-4124
EI 1747-4132
J9 EXPERT REV GASTROENT
JI Expert Rev. Gastroenterol. Hepatol.
PD NOV 2
PY 2021
VL 15
IS 11
BP 1309
EP 1318
DI 10.1080/17474124.2021.1967143
EA AUG 2021
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA XC5LZ
UT WOS:000685994800001
PM 34384325
DA 2026-07-24
ER
PT J
AU Frear, CC
   Griffin, BR
   Cuttle, L
   Kimble, RM
   McPhail, SM
AF Frear, Cody C.
   Griffin, Bronwyn R.
   Cuttle, Leila
   Kimble, Roy M.
   McPhail, Steven M.
TI Cost-effectiveness of adjunctive negative pressure wound therapy in
   paediatric burn care: evidence from the SONATA in C randomised
   controlled trial
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ASSISTED CLOSURE DEVICE; PARTIAL-THICKNESS BURNS; SUBATMOSPHERIC
   PRESSURE; ECONOMIC-EVALUATION; UTILITY ANALYSIS; HEALING TIME;
   MANAGEMENT; SCARS; EPIDEMIOLOGY; PROGRESSION
AB Negative pressure wound therapy (NPWT) has been shown to improve clinical outcomes for children with burns by accelerating wound re-epithelialisation. Its effects on healthcare costs, however, remain poorly understood. The aim of this study was to evaluate the cost-effectiveness of NPWT from a healthcare provider perspective using evidence from the SONATA in C randomised controlled trial, in which 101 children with small-area burns were allocated to either standard care (silver-impregnated dressings) or standard care in combination with adjunctive NPWT. The primary outcome, time to re-epithelialisation, was assessed through a blinded photographic review. Resource usage and costs were prospectively recorded for each participant for up to 6 months. Incremental cost-effectiveness ratios and dominance probabilities were estimated and uncertainty quantified using bootstrap resampling. Mean costs per participant-including dressings, labour, medication, scar management, and theatre operations-were lower in the NPWT group (AUD $903.69) relative to the control group (AUD $1669.01). There was an 89% probability that NPWT was dominant, yielding both faster re-epithelialisation and lower overall costs. Findings remained robust to sensitivity analyses employing alternative theatre costs and time-to-re-epithelialisation estimates for grafted patients. In conclusion, adjunctive NPWT is likely to be a cost-effective and dominant treatment for small-area paediatric burns (ANZCTR.org.au:ACTRN12618000256279).
C1 [Frear, Cody C.; Griffin, Bronwyn R.; Cuttle, Leila; Kimble, Roy M.] Univ Queensland, Child Hlth Res Ctr, Ctr Childrens Burns & Trauma Res, Level 7,62 Graham St, South Brisbane, Qld 4101, Australia.
   [Frear, Cody C.; Kimble, Roy M.] Univ Queensland, Fac Med, Herston, Qld, Australia.
   [Griffin, Bronwyn R.] Griffith Univ, Menzies Hlth Inst Queensland, Southport, Qld, Australia.
   [Cuttle, Leila] Queensland Univ Technol, Fac Hlth, Sch Biomed Sci, Brisbane, Qld, Australia.
   [Kimble, Roy M.] Queensland Childrens Hosp, South Brisbane, Australia.
   [McPhail, Steven M.] Queensland Univ Technol, Fac Hlth, Sch Publ Hlth & Social Work, Australian Ctr Hlth Serv Innovat, Brisbane, Qld, Australia.
   [McPhail, Steven M.] Queensland Univ Technol, Fac Hlth, Sch Publ Hlth & Social Work, Ctr Healthcare Transformat, Brisbane, Qld, Australia.
   [McPhail, Steven M.] Metro South Hlth, Clin Informat Directorate, Brisbane, Qld, Australia.
C3 University of Queensland; University of Queensland; Griffith University;
   Queensland University of Technology (QUT); Childrens Health Queensland
   Hospital & Health Service; Queensland Childrens Hospital; Queensland
   University of Technology (QUT); Queensland University of Technology
   (QUT)
RP Frear, CC (通讯作者)，Univ Queensland, Child Hlth Res Ctr, Ctr Childrens Burns & Trauma Res, Level 7,62 Graham St, South Brisbane, Qld 4101, Australia.; Frear, CC (通讯作者)，Univ Queensland, Fac Med, Herston, Qld, Australia.
EM cody.frear@uqconnect.edu.au
RI McPhail, Steven/JMR-2141-2023; Griffin, Bronwyn/AEB-6299-2022; Kimble,
   Roy/B-4160-2011; Cuttle, Leila/C-5223-2008
OI McPhail, Steven/0000-0002-1463-662X; Griffin,
   Bronwyn/0000-0002-6182-9125; Cuttle, Leila/0000-0002-2282-4815
FU Australian Government, National Health and Medical Research Council
   [APP1196436, APP1130862, APP1161138]
FX The authors thank the children and families who participated in the
   SONATA in C trial, without whom this research would not have been
   possible. They are grateful for the support of the clinicians at the
   Pegg Leditschke Children's Burn Centre and Queensland Children's
   Hospital Emergency Department. They would further like to acknowledge
   Crystle Gambetta, Fiona Gregory, Frank Hurley, Catherine McMillan, and
   Kate Miller for their generous contributions to the collection of
   costing details. B.R.G., L.C. and S.M.M. acknowledge funding from the
   Australian Government, National Health and Medical Research Council
   (APP1196436, APP1130862 and APP1161138, respectively).
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NR 50
TC 16
Z9 17
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 17
PY 2021
VL 11
IS 1
AR 16650
DI 10.1038/s41598-021-95893-9
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA UC7GU
UT WOS:000686690900072
PM 34404842
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Petca, A
   Negoita, S
   Petca, RC
   Borislavschi, A
   Calo, IG
   Popescu, VG
   Sinescu, RD
AF Petca, Aida
   Negoita, Silvius
   Petca, Razvan-Cosmin
   Borislavschi, Andreea
   Calo, Ioana Gabriela
   Popescu, Valentina Gabriela
   Sinescu, Ruxandra Diana
TI BACTERIAL PATHOGENS ISOLATED FROM SURGICAL SITE INFECTIONS AND THEIR
   ANTIBIOTIC SUSCEPTIBILITY
SO FARMACIA
LA English
DT Article
DE pathogens; MDR bacterial pathogens; surgical site infections;
   vacuum-assisted closure; hospital-acquired infections
ID ANTIMICROBIAL SUSCEPTIBILITY; RESISTANCE; SURVEILLANCE; GUIDELINES
AB The increased reservoir of pathogenic bacteria sheltered in hospitals is the cause of various types of nosocomial infections and represents one of the major health problems. Surgical site infections (SSIs) count for 14 - 16% of all hospital-acquired infections (HAI) and represent the 3rd most occurring nosocomial infections and the 3rd most expensive HAI. We present a germ pattern (on 92 strains), located in post-operative dehiscence sites - treated with vacuum-assisted closure, in failed per secundam suture. The most common pathogens were E. coli - 18.47% (76.47% multi-drug resistant - MDR), Pseudomonas aeruginosa - 16.30% (33.33% MDR) and Enterococcus faecalis - 15.21%. Acinetobacter baumannii (100%) and Klebsiella pneumoniae (88.88%) also showed multi-drug resistance. Gentamicin, amikacin and carbapenems (> 50% sensibility) are eligible for treating SSIs, whereas cephalosporins have a higher resistance rate (> 50%). Knowledge of resistance patterns in SSIs is recommendable to ensure proper empirical treatment.
C1 [Petca, Aida; Borislavschi, Andreea; Calo, Ioana Gabriela] Carol Davila Univ Med & Pharm, Elias Univ Emergency Hosp, Dept Obstet & Gynaecol, Bucharest, Romania.
   [Negoita, Silvius] Carol Davila Univ Med & Pharm, Elias Univ Emergency Hosp, Dept Anaesthesiol & Crit Care, Bucharest, Romania.
   [Petca, Razvan-Cosmin] Carol Davila Univ Med & Pharm, Prof Dr Th Burghele Clin Hosp, Dept Urol, Bucharest, Romania.
   [Popescu, Valentina Gabriela] Elias Univ Emergency Hosp, Dept Vasc Surg, Bucharest, Romania.
   [Sinescu, Ruxandra Diana] Carol Davila Univ Med & Pharm, Elias Univ Emergency Hosp, Dept Plast Surg & Reconstruct Microsurg, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy;
   Carol Davila University of Medicine & Pharmacy
RP Borislavschi, A (通讯作者)，Carol Davila Univ Med & Pharm, Elias Univ Emergency Hosp, Dept Obstet & Gynaecol, Bucharest, Romania.
EM andreea.borislavschi@gmail.com
RI Petca, Aida/AAM-9912-2020; /ABD-2479-2020; Borislavschi,
   Andreea/HMD-4904-2023; Visan, Ioana Gabriela/LWI-3374-2024; NEGOITA,
   SILVIUS/AAG-2433-2021; Petca, Răzvan-Cosmin/AAH-2462-2020
OI Visan, Ioana Gabriela/0000-0001-6134-0728; 
FU CNCSIS-UEFISCDI, Postdoctoral Fellowship Programme PN-II-Human Resources
   [3/28.07.2010, PD 149/2010]
FX This work was financially supported by CNCSIS-UEFISCDI, Postdoctoral
   Fellowship Programme PN-II-Human Resources, project number 3/28.07.2010,
   code PD 149/2010.
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NR 45
TC 8
Z9 9
U1 3
U2 11
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD JUL-AUG
PY 2021
VL 69
IS 4
BP 741
EP 748
DI 10.31925/farmacia.2021.4.15
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UD2JT
UT WOS:000687039600015
OA gold
DA 2026-07-24
ER
PT J
AU Book, T
   Wortmann, N
   Winkler, M
   Kirstein, MM
   Heidrich, B
   Wedemeyer, H
   Voigtländer, T
AF Book, Thorsten
   Wortmann, Nicolas
   Winkler, Michael
   Kirstein, Martha M.
   Heidrich, Benjamin
   Wedemeyer, Heiner
   Voigtlaender, Torsten
TI Endoscopic vacuum assisted closure (E-VAC) of upper gastrointestinal
   leakages
SO SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Endoscopic vacuum-assisted closure( E-VAC); esophageal perforations;
   postoperative leakage; gastrointestinal leakages; esophagogastrostomies
ID DEVICE
AB Objectives Endoscopic vacuum-assisted closure (E-VAC) of leaks of the upper gastrointestinal tract is an increasingly applied endoscopic technique. Data on indication, clinical success, complications and prognostic factors are still sparse. Methods Patients treated with E-VAC between 2012 and 2019 at a tertiary referral center have been retrospectively analyzed. Results Overall, 116 patients treated with E-VAC were identified. Indication for E-VAC placement was postoperative leakage in 94/116 (81%), iatrogenic perforations 7/116 (6%) and others 15/116 (13%). In 92/116 (79%) of the patients E-VAC therapy showed successful wound closure. The first E-VAC after detection of insufficiency was significantly more often placed intracavitary in patients with E-VAC failure (p = .031). There was a trend for longer intensive care unit treatment for patients with E-VAC failure (p = .069). Complications occurred significantly more often in patients with E-VAC failure (p = .009). Platelet count was significantly higher in patients with E-VAC success at day of insufficiency detection (257/Thsd/mu L (interquartile range [IQR], 185-362) vs. 195 (IQR, 117-309); p = .039). Platelet count (375 Thsd/mu L (IQR, 256-484) vs. 190 (IQR, 129-292)), hemoglobin (9.5 g/dL (IQR, 8.8-10.1) vs. 8.7 g/dL (IQR, 8.15-9.35)) and C-reactive protein level (79 mg/L (IQR, 39.7-121.9) vs. 152 mg/L (IQR, 73.7-231)) at day 14 differed significantly. The 30 days mortality rate was 33.3% (8/24) in E-VAC failure compared with 2.2% in patients with E-VAC success (p = .001). Conclusions E-VAC is an emerging highly effective interventional endoscopic technique for gastrointestinal wound closure even in highly selected patients.
C1 [Book, Thorsten; Heidrich, Benjamin; Wedemeyer, Heiner; Voigtlaender, Torsten] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [Wortmann, Nicolas] Univ Hosp Munster, Dept Gastroenterol & Hepatol, Munster, Germany.
   [Winkler, Michael] Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, Hannover, Germany.
   [Kirstein, Martha M.] Univ Med Ctr Schleswig Holstein, Dept Med 1, Lubeck, Germany.
C3 Hannover Medical School; University of Munster; Hannover Medical School;
   University of Kiel; Schleswig Holstein University Hospital
RP Voigtländer, T (通讯作者)，Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM voigtlaender.torsten@mh-hannover.de
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NR 15
TC 10
Z9 10
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5521
EI 1502-7708
J9 SCAND J GASTROENTERO
JI Scand. J. Gastroenterol.
PD NOV 2
PY 2021
VL 56
IS 11
BP 1376
EP 1379
DI 10.1080/00365521.2021.1963836
EA AUG 2021
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA WI2SV
UT WOS:000687082600001
PM 34420453
DA 2026-07-24
ER
PT J
AU Carney, BC
   Johnson, LS
   Shupp, JW
   Travis, TE
AF Carney, Bonnie C.
   Johnson, Laura S.
   Shupp, Jeffrey W.
   Travis, Taryn E.
TI Initial Experience Combining Negative Pressure Wound Therapy With
   Autologous Skin Cell Suspension and Meshed Autografts
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID GRAFT
AB The success of autologous split-thickness skin grafts (STSGs) in the treatment of full-thickness burns is often dependent on the dressing used to secure it. Tie-over bolsters have been used traditionally; however, they can be uncomfortable for patients and preclude grafting large areas in one definitive operation. Negative pressure wound therapy (NPWT) is used as an alternative to bolster dressings and may afford additional wound healing benefits. In our center, NPWT has become the dressing of choice for securing STSGs. While the RECELL (R) system is being used in conjunction with STSGs, it is currently unknown whether autologous skin cell suspensions (ASCS) can be used with NPWT. This report is a retrospective chart review of nine patients treated in this manner. All wounds were almost completely re-epithelialized within 14 days, and their healing was as expected. Wound healing trajectories are shown. There were no significant complications in these patients. This dressing technique can be considered as an option when using ASCS and widely meshed STSG.
C1 [Carney, Bonnie C.; Shupp, Jeffrey W.] Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, Washington, DC 20007 USA.
   [Carney, Bonnie C.; Johnson, Laura S.; Shupp, Jeffrey W.; Travis, Taryn E.] MedStar Hlth Res Inst, Firefighters Burn & Surg Res Lab, Washington, DC USA.
   [Carney, Bonnie C.; Johnson, Laura S.; Shupp, Jeffrey W.; Travis, Taryn E.] Georgetown Univ, Sch Med, Dept Surg, Washington, DC USA.
   [Johnson, Laura S.; Shupp, Jeffrey W.; Travis, Taryn E.] MedStar Washington Hosp Ctr, Burn Ctr, Dept Surg, 110 Irving St NW,Suite 3B-55, Washington, DC 20010 USA.
C3 Georgetown University; MedStar Health Research Institute; Georgetown
   University; MedStar Washington Hospital Center
RP Travis, TE (通讯作者)，MedStar Washington Hosp Ctr, Burn Ctr, Dept Surg, 110 Irving St NW,Suite 3B-55, Washington, DC 20010 USA.
EM Taryn.E.Travis@medstar.net
RI Shupp, Jeffrey/AAW-3481-2021; Travis, Taryn/AAK-8527-2021; Johnson,
   Laura S/ABE-5478-2020
OI Johnson, Laura S/0000-0001-6969-2648
CR Carney BC, J SURG RES, V2021
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   Kantak NA, 2017, CLIN PLAST SURG, V44, P671, DOI 10.1016/j.cps.2017.02.023
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NR 16
TC 5
Z9 5
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2021
VL 42
IS 4
BP 633
EP 641
DI 10.1093/jbcr/irab075
EA APR 2021
PG 9
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA UE2WA
UT WOS:000687752900007
PM 33903907
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Nolff, MC
AF Nolff, Mirja C.
TI Filling the vacuum: Role of negative pressure wound therapy in open
   wound management in cats
SO JOURNAL OF FELINE MEDICINE AND SURGERY
LA English
DT Review
DE Open wound treatment; cat wound healing; skin grafts; negative pressure
   wound therapy
ID THICKNESS SKIN-GRAFTS; COATED FOAM DRESSINGS; ASSISTED CLOSURE;
   RETROSPECTIVE EVALUATION; CHLORHEXIDINE DIACETATE; DOGS; GRANULATION;
   REPAIR; MECHANISM; RESPONSES
AB Practical relevance: Open wounds and their treatment present a common challenge in veterinary practice. Approaching 15 years ago negative pressure wound therapy (NPWT) started to be incorporated into clinical veterinary medicine, and its availability is becoming more widespread in Europe and the USA. Use of this therapy has the potential to significantly increase the healing rate of open wounds as well as free skin grafts in small animals, and it has been occasionally described for the management of feline wounds. Aim: This review describes the mechanisms of action of, and indications for, NPWT, and offers recommendations for NPWT specific to feline patients. Evidence base: The information presented is based on the current evidence and the author's clinical experience of the technique gained over the past 12 years. Comparative studies of different treatment options are lacking and, since wound healing in cats and dogs differs, cat-specific studies are especially needed. Well-designed wound healing studies comparing different advanced techniques will improve open wound healing in cats in the future, and potentially allow better understanding of the role of NPWT in this setting.
C1 [Nolff, Mirja C.] Univ Zurich, Tierspital Zurich, Clin Small Anim Surg, Winterthurerstr 260, CH-8057 Zurich, Switzerland.
C3 University of Zurich
RP Nolff, MC (通讯作者)，Univ Zurich, Tierspital Zurich, Clin Small Anim Surg, Winterthurerstr 260, CH-8057 Zurich, Switzerland.
EM mirjachristine.nolff@uzh.ch
RI Nolff, Mirja/W-6756-2019
OI Nolff, Mirja/0000-0001-9317-7769
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NR 72
TC 7
Z9 10
U1 0
U2 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1098-612X
EI 1532-2750
J9 J FELINE MED SURG
JI J. Feline Med. Surg.
PD SEP
PY 2021
VL 23
IS 9
BP 823
EP 833
DI 10.1177/1098612X211037873
PG 11
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA UF4ER
UT WOS:000688528700002
PM 34428942
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Ritz, LA
   Hajji, MS
   Schwerd, T
   Koletzko, S
   von Schweinitz, D
   Lurz, E
   Hubertus, J
AF Ritz, Laura Antonia
   Hajji, Mohammad Samer
   Schwerd, Tobias
   Koletzko, Sibylle
   von Schweinitz, Dietrich
   Lurz, Eberhard
   Hubertus, Jochen
TI Esophageal Perforation and EVAC in Pediatric Patients: A Case Series of
   Four Children
SO FRONTIERS IN PEDIATRICS
LA English
DT Article
DE esophageal perforation; VAC; vacuum therapy; children; pediatric
   patients
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; THERAPY; DEFECTS; LEAKAGE; DEVICE;
   SYSTEM; STENT
AB Introduction: In pediatric patients, esophageal perforation (EP) is rare but associated with significant morbidity and mortality rates of up to 20-30%. In addition to standard treatment options, endoscopic esophageal vacuum-assisted closure (EVAC) therapy has shown promising results, especially in adult patients. Thus far, the only data on technical success and effectiveness of EVAC in pediatric patients were published in 2018 by Manfredi et al. at Boston Children's Hospital. The sparse data on EVAC in children indicates that this promising technique has been barely utilized in pediatric patients. More data are needed to evaluate efficacy and outcomes of this technique in pediatric patients.
   Method: We reviewed five cases of therapy using EVAC, ArgyleTM Replogle Suction Catheter (RSC), or both on pediatric patients with EP in our institution between October 2018 and April 2020.
   Results: Five patients with EP (median 3.4 years; 2 males) were treated with EVAC, RSC, or a combination. Complete closure of EP was not achieved after EVAC alone, though patients' health stabilized and inflammation and size of EP decreased after EVAC. Four patients then were treated with RSC until the EP healed. One patient needed surgery as the recurrent fistula did not heal sufficiently after 3 weeks of EVAC therapy. Two patients developed stenosis and were successfully treated with dilatations. One patient treated with RSC alone showed persistent EP after 5 weeks.
   Conclusion: EVAC in pediatric patients is technically feasible and a promising method to treat EP, regardless of the underlying cause. EVAC therapy can be terminated as soon as local inflammation and C-reactive protein levels decrease, even if the mucosa is not healed completely at that time. A promising subsequent treatment is RSC. An earlier switch to RSC can substantially reduce the need of anesthesia during subsequent treatments. Our findings indicate that EVAC is more effective than RSC alone. In some cases, EVAC can be used to improve the tissues condition in preparation for a re-do surgery. At 1 year after therapy, all but one patient demonstrated sufficient weight gain. Further prospective studies with a larger cohort are required to confirm our observations from this small case series.
C1 [Ritz, Laura Antonia; von Schweinitz, Dietrich; Hubertus, Jochen] Ludwig Maximilian Univ Munich, Dept Pediat Surg, Dr von Hauner Childrens Hosp, Munich, Germany.
   [Hajji, Mohammad Samer; Schwerd, Tobias; Koletzko, Sibylle; Lurz, Eberhard] Ludwig Maximilian Univ Munich, Dr von Hauner Childrens Hosp, Dept Pediat Gastroenterol, Munich, Germany.
C3 University of Munich; University of Munich
RP Hubertus, J (通讯作者)，Ludwig Maximilian Univ Munich, Dept Pediat Surg, Dr von Hauner Childrens Hosp, Munich, Germany.
EM jochen.hubertus@med.uni-muenchen.de
RI Koletzko, Sibylle/KFB-8405-2024; Hubertus, Jochen/AAW-7790-2021
OI Lurz, Eberhard/0000-0002-7479-7388; Hubertus, Jochen/0000-0003-3206-6170
CR ATTAR S, 1990, ANN THORAC SURG, V50, P45, DOI 10.1016/0003-4975(90)90082-H
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   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
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NR 36
TC 11
Z9 12
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2360
J9 FRONT PEDIATR
JI Front. Pediatr.
PD AUG 6
PY 2021
VL 9
AR 727472
DI 10.3389/fped.2021.727472
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA UH8FO
UT WOS:000690159600001
PM 34458215
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sandra-Petrescu, F
   Tzatzarakis, E
   Kähler, G
   Reissfelder, C
   Herrle, F
AF Sandra-Petrescu, Flavius
   Tzatzarakis, Emmanouil
   Kaehler, Georg
   Reissfelder, Christoph
   Herrle, Florian
TI Management of colorectal anastomotic leakage using endoscopic negative
   pressure therapy with or without protective ostomy: a retrospective
   study
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Vacuum therapy; Colorectal anastomosis; Leak; Colorectal surgery; Lack
   of protective ostomy; Management algorithm
ID VACUUM-ASSISTED CLOSURE; LONG-TERM EFFICACY; RECTAL-CANCER; ANTERIOR
   RESECTION; SURGERY; STOMA
AB Purpose Management of colorectal anastomotic leakage (AL) is patient-oriented and requires an interdisciplinary approach. We analyzed the management of AL according to its severity and presence of ostomy and proposed a therapy algorithm. Methods We identified all patients who underwent colorectal surgery and developed an AL in our clinic between 2012 and 2017. The management of AL was retrospectively analyzed according to the severity grade: asymptomatic (A), requesting interventional or antibiotic therapy (B), undergoing re-operation (C). The groups were compared according to the leakage characteristics, presence of ostomy, and patient clinical conditions. Results We identified 784 consecutive patients meeting the inclusion criteria. Of these, 10.8% experienced an AL (A = 18%, B = 48%, and C = 34%). The rate of successful ostomy closure was 100% (A), 68% (B), and 62% (C), respectively. Within group B, 91% of the patients were treated solely by endoscopic negative pressure therapy (ENPT), whereas 37% of the patients within group C required ENPT in addition to surgery. Seven cases within group B (17%) required no protective ostomy (nOB) during ENPT which was itself shorter and required less cycles in comparison to group B with ostomy (OB) (p = 0.017 and 0.111, respectively). Moreover, the leakage distance to anal verge was higher in the OB subgroup (p < 0.001). Conclusion ENPT for the treatment of colorectal AL is efficient in combination with operative revision or protective ostomy. In selected patients, it is feasible also in the absence of a protective ostomy.
C1 [Sandra-Petrescu, Flavius; Tzatzarakis, Emmanouil; Reissfelder, Christoph; Herrle, Florian] Univ Klinikum Mannheim, Chirurg Klin, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
   [Kaehler, Georg] Univ Klinikum Mannheim, Chirurg Klin, Interdisziplinare Endoskopie, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
C3 Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg
RP Sandra-Petrescu, F (通讯作者)，Univ Klinikum Mannheim, Chirurg Klin, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
EM flavius.sandra-petrescu@umm.de; emmanouil.tzatzarakis@umm.de;
   georg.kaehler@umm.de; christoph.reissfelder@umm.de;
   florian.herrle@umm.de
RI Reissfelder, Christoph/HRA-4846-2023
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
CR Arezzo A, 2015, DIGEST LIVER DIS, V47, P342, DOI 10.1016/j.dld.2014.12.003
   Chopra SS, 2009, SURGERY, V145, P182, DOI 10.1016/j.surg.2008.09.012
   Daams F, 2012, DIGEST SURG, V29, P516, DOI 10.1159/000346348
   Herrle F, 2016, DIS COLON RECTUM, V59, P281, DOI 10.1097/DCR.0000000000000545
   Hüser N, 2008, ANN SURG, V248, P52, DOI [10.1097/SLA.0b013e18176bf65, 10.1097/SLA.0b013e318176bf65]
   Kähler G, 2017, VISC MED, V33, P202, DOI 10.1159/000475783
   Keskin M, 2015, SURG LAPARO ENDO PER, V25, P505, DOI 10.1097/SLE.0000000000000216
   Kouladouros K, 2021, SCAND J GASTROENTERO, V56, P193, DOI 10.1080/00365521.2020.1861645
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   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
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   Phitayakorn R, 2008, WORLD J SURG, V32, P1147, DOI 10.1007/s00268-008-9468-1
   Platell C, 2007, COLORECTAL DIS, V9, P71, DOI 10.1111/j.1463-1318.2006.01002.x
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   Rullier E, 1998, BRIT J SURG, V85, P355
   Shalaby M, 2019, BJS OPEN, V3, P153, DOI 10.1002/bjs5.50124
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   van Helsdingen CPM, 2020, WORLD J GASTROENTERO, V26, DOI 10.3748/wjg.v26.i23.3293
   van Koperen PJ, 2009, SURG ENDOSC, V23, P1379, DOI 10.1007/s00464-008-0186-4
   von Bernstorff W, 2009, INT J COLORECTAL DIS, V24, P819, DOI 10.1007/s00384-009-0673-7
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 24
TC 7
Z9 9
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD OCT
PY 2021
VL 36
IS 10
BP 2261
EP 2269
DI 10.1007/s00384-021-04011-8
EA AUG 2021
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA UP6II
UT WOS:000690702200002
PM 34455472
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Myllykangas, HM
   Halonen, J
   Husso, A
   Berg, LT
AF Myllykangas, Heidi-Mari
   Halonen, Jari
   Husso, Annastiina
   Berg, Leena T.
TI Decreasing complications of pectoralis major muscle flap reconstruction
   with two modalities of negative pressure wound therapy
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Mediastinitis; sternotomy; muscle flap; negative pressure wound therapy;
   surgical wound infection
ID OPEN-HEART-SURGERY; STERNAL WOUNDS; INFECTIONS; ADVANCEMENT; MANAGEMENT
AB Background and objective: Deep sternal wound infection is a feared complication of open-heart surgery. Negative pressure wound therapy has gained an important role in the treatment of deep sternal wound infection. Incisional negative pressure wound therapy has been introduced as a method to prevent wound complications after sternotomy, and lately, after flap reconstructions in the treatment of deep sternal wound infection. We aimed to study if incisional negative pressure wound therapy with PICO (TM) had similar beneficial effect described earlier with competing commercial devices.
   Methods: This study included 82 patients treated with pectoralis major muscle flap for deep sternal wound infection during the years 2006-2020. PICO group consisted of 24 patients treated with preoperative negative pressure wound therapy and postoperative incisional negative pressure wound therapy (PICO (TM)). Two control groups included 48 patients with conventional treatment and 10 patients with preoperative negative pressure wound therapy only.
   Results: In the PICO group, the complication rate declined from 50.0% to 33.30%, major complication rate from 29.2% to 12.5%, and need for an additional flap from 14.6.% to 4.2% when compared to conventional treatment. The length of hospital stay decreased as well. Preoperative negative pressure wound therapy alone was associated with moderate decline in the complication rates. In addition, we described the use of split pectoralis major muscle flap reconstruction in 57 patients. To our knowledge, this is the largest published patient series describing this method in the treatment of deep sternal wound infection.
   Conclusions: Incisional negative pressure wound therapy with PICO (TM) seems beneficial after flap reconstruction. Split pectoralis major muscle flap is a versatile reconstruction option suitable to be used as a workhorse in the treatment of deep sternal wound infection.
C1 [Myllykangas, Heidi-Mari] Kuopio Univ Hosp, Dept Plast Surg, PL 100, Kuopio 70029, Finland.
   [Halonen, Jari] Univ Eastern Finland, Kuopio, Finland.
   [Halonen, Jari; Husso, Annastiina] Kuopio Univ Hosp, Dept Cardiothorac Surg, Kuopio, Finland.
   [Berg, Leena T.] Kainuu Cent Hosp, Dept Plast Surg, Kajaani, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Eastern Finland; Kuopio
   University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital
RP Myllykangas, HM (通讯作者)，Kuopio Univ Hosp, Dept Plast Surg, PL 100, Kuopio 70029, Finland.
EM Heidi.myllykangas@kuh.fi
RI Halonen, Jari/K-9329-2018
OI Husso, Annastiina/0000-0001-7109-1876; Myllykangas,
   Heidi-Mari/0000-0003-0542-987X
CR Ascherman JA, 2004, PLAST RECONSTR SURG, V114, P676, DOI 10.1097/01.PRS.0000130939.32238.3B
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   Nickl S, 2018, J RECONSTR MICROSURG, V34, P1, DOI 10.1055/s-0037-1605379
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   Rashed A, 2017, INT WOUND J, V14, P180, DOI 10.1111/iwj.12579
   Ruggieri VG, 2019, HEART SURG FORUM, V22, pE92, DOI 10.1532/hsf.2269
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   Semsarzadeh NN, 2015, PLAST RECONSTR SURG, V136, P592, DOI 10.1097/PRS.0000000000001519
   Singh Kimberly, 2011, Semin Plast Surg, V25, P25, DOI 10.1055/s-0031-1275168
   Spartalis E, 2016, SURG TODAY, V46, P460, DOI 10.1007/s00595-015-1192-5
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   Tabley A, 2020, ANN THORAC SURG, V110, P2034, DOI 10.1016/j.athoracsur.2020.03.087
NR 25
TC 4
Z9 6
U1 1
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD MAR
PY 2022
VL 111
IS 1
DI 10.1177/14574969211043330
EA SEP 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3Y1NB
UT WOS:000692860300001
PM 34486448
OA hybrid
DA 2026-07-24
ER
PT J
AU Ouyang, WJ
   Wang, M
   Jin, LL
AF Ouyang, Wenjuan
   Wang, Min
   Jin, Lingli
TI The effect of vacuum sealing drainage after early woundabrasion on wound
   healing in diabetic patients with deep second degree burn and its
   influence on the inflammatory response
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Diabetes; deep second degree burn; early woundabrasion; vacuum sealing
   drainage; wound healing; inflammatory response
AB Objective: To investigate the effect of vacuum sealing drainage (VSD) after early woundabrasion (WA) in diabetic patients with deep second degree burn (DSDB). Methods: This prospective study selected 89 diabetic patients with DSDB treated in our hospital. Using the random number table method, the patients were divided into the control group (44 cases with conventional treatment after early WA) and observation group (45 cases with VSD treatment after WA). Wound healing, fungal infection rate, serum levels of inflammatory factors and vascular endothelial growth factor (VEGF), and adverse reactions in both groups were compared. Results: After 2 weeks of treatment, the total effective rate of observation group was higher than that of control group, and the incidence of adverse reactions showed an opposite trend (both P<0.05). Compared with the control group, the wound healing time was shortened, the wound healing rate was increased, and the fungal infection rate was decreased in the observation group (all P<0.05). Compared with before treatment, serum TNF-alpha levels in both groups were decreased, while serum levels of IL-10, IL-4 and VEGF were increased after treatment, and the changes in the observation group were more obvious (all P<0.05). Conclusions: In diabetic patients with DSDB, VSD after early WA can effectively reduce the incidence of fungal infection, reduce inflammation, improve VEGF level, and facilitate wound healing.
C1 [Ouyang, Wenjuan; Wang, Min] Wuhan Univ, Hanchuan Peoples Hosp, Peoples Hosp, Hanchuan Hosp,Dept Wound Repair & Plast Burn, Xiaogan, Hubei, Peoples R China.
   [Jin, Lingli] Wuhan Univ, Hanchuan Peoples Hosp, Peoples Hosp, Hanchuan Hosp,Dept Tradit Chinese Med, 1 Renmin Ave, Xiaogan 431600, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Jin, LL (通讯作者)，Wuhan Univ, Hanchuan Peoples Hosp, Peoples Hosp, Hanchuan Hosp,Dept Tradit Chinese Med, 1 Renmin Ave, Xiaogan 431600, Hubei, Peoples R China.
EM jinlingli688@sina.com
CR Ahmed Khan T, 2018, BMJ CASE REP, V2018, P28
   Aries P, 2018, J CLIN PATHOL, V71, P379, DOI 10.1136/jclinpath-2017-204858
   Chai J K, 2018, Zhonghua Shao Shang Za Zhi, V34, P332, DOI 10.3760/cma.j.issn.1009-2587.2018.06.004
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NR 22
TC 4
Z9 6
U1 0
U2 6
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2021
VL 13
IS 8
BP 9814
EP 9819
PG 6
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA UM1TL
UT WOS:000693121000043
PM 34540115
DA 2026-07-24
ER
PT J
AU Wu, J
   Qin, Y
   Li, ZR
   Li, JT
   Li, LT
   Tao, S
   Liu, DH
AF Wu, Jie
   Qin, Yong
   Li, Zhirui
   Li, Jiantao
   Li, Litao
   Tao, Sheng
   Liu, Daohong
TI Comprehensive analysis of lncRNA and miRNA expression profiles and ceRNA
   network construction in negative pressure wound therapy
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Negative pressure wound therapy (NPWT); next-generation sequencing;
   transcriptome; noncoding RNAs
ID VACUUM-ASSISTED CLOSURE; DOWN-REGULATION; INFLAMMATION; MICRORNAS;
   TARGET; CD45
AB Background: This study aims to explore the molecular mechanism of negative pressure wound therapy (NPWT) at the transcriptome level through whole transcriptome sequencing and biometric analysis.
   Methods: A rat skin defect model was constructed and randomly divided into a NPWT group and a gauze group. The tissue in the center of the wound was used for whole transcriptome sequencing, and differentially expressed messenger RNAs (DEmRNAs), long noncoding RNAs (DElncRNAs), and microRNAs (DEmiRNAs) were identified between the two groups. Quantitative real time-polymerase chain reaction (qRT-PCR) analysis was used to verify the sequencing results. Functional enrichment analysis, pathway analysis, and protein-protein interaction (PPI) network analysis of DEmRNAs were conducted. Through bioinformatics analysis, a lncRNA-associated competing endogenous RNA (ceRNA) network was identified and constructed.
   Results: We detected 896 DEmRNAs, 1,471 DElncRNAs, and 20 DEmiRNAs between the two groups. qRT-PCR verified the sequencing results. Functional analysis showed that DEmRNAs were mainly enriched in immune system processes and the Notch signaling pathway. Protein tyrosine phosphatase receptor type C (PTPRC) and signal transducer and activator of transcription 1 (STAT1) were the central hub nodes in the PPI analysis. The ceRNA network contained 11 mRNAs, 15 lncRNAs, and 4 miRNAs.
   Conclusions: We identified several DEmRNAs, DElncRNAs, and DEmiRNAs between the NPWT treatment group and the control group. These findings may provide new insights into the pathophysiological mechanism of NPWT and wound healing.
C1 [Wu, Jie; Li, Litao; Tao, Sheng; Liu, Daohong] Peoples Liberat Army Gen Hosp, Dept Orthoped, Med Ctr 8, Beijing, Peoples R China.
   [Qin, Yong] Harbin Med Univ, Dept Orthoped, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R China.
   [Li, Zhirui] Peoples Liberat Army Gen Hosp, Dept Orthoped, Hainan Hosp, Sanya, Peoples R China.
   [Li, Zhirui; Li, Jiantao; Li, Litao; Tao, Sheng; Liu, Daohong] Peoples Liberat Army Gen Hosp, Senior Dept Orthoped, Med Ctr 4, Beijing, Peoples R China.
   [Li, Jiantao; Liu, Daohong] Natl Clin Res Ctr Orthoped Sports Med & Rehabil, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Harbin Medical
   University; Chinese People's Liberation Army General Hospital; Chinese
   People's Liberation Army General Hospital
RP Tao, S; Liu, DH (通讯作者)，Peoples Liberat Army Gen Hosp, Dept Orthoped, Med Ctr 8, Beijing, Peoples R China.
EM taoshphy@126.com; domb@vip.sina.com
RI ; Li, Zhirui/OJT-0490-2025
OI Wu, Jie/0000-0002-6572-9762; 
FU Major Project of Military Logistics Research [AWS17J004-02-13]
FX This study was supported by the Major Project of Military Logistics
   Research (No. AWS17J004-02-13).
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NR 45
TC 4
Z9 5
U1 0
U2 10
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD SEP
PY 2021
VL 9
IS 17
AR 1383
DI 10.21037/atm-21-3626
EA AUG 2021
PG 14
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA ZN8RK
UT WOS:000693235600001
PM 34733935
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, HR
   Yang, P
   Han, S
   Zhang, Y
   Zhu, HY
AF Liu, Han-Rong
   Yang, Ping
   Han, Song
   Zhang, Yu
   Zhu, Hui-Yin
TI The application of enhanced recovery after surgery and negative-pressure
   wound therapy in the perioperative period of elderly patients with
   colorectal cancer
SO BMC SURGERY
LA English
DT Article
DE Enhanced recovery after surgery; Colorectal cancer; The elderly patient;
   Negative-pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; COLONIC SURGERY; RANDOMIZED-TRIAL;
   RECTAL-CANCER; CARE; METAANALYSIS; IMPACT; GUIDELINES; REHABILITATION;
   INFECTIONS
AB Objective To Explore the perioperative application of enhanced recovery after surgery (ERAS) and negative-pressure wound therapy in the elderly patients with colorectal cancer. Methods A retrospective clinical data were studied in the patients with colorectal cancer in Department of General Surgery in Shanghai Fourth People,s Hospital (from March, 2017 to March, 2019), One hundred and fifty patients with undergoing radical surgery for colorectal cancer were divided into two groups: ERAS group (n = 76 cases, accepting ERAS management) and Conventional treatment(CT) group (n = 74 cases, accepting traditional treatment), Bleeding in operation, the time of postoperative anal flatus, number of wound dressing changing, time of wound healing, the length of postoperative hospital stay, readmission rate, postoperative complication, were compared between the two groups. Results ERAS was associated with less bleeding in operation, less Wound fat liquefaction, less wound dressing changing, less time of wound healing, less time of postoperative anal flatus compare to CT group (P < 0.05); anastomotic fistula, readmission rate is similar in two groups (P > 0.05). Conclusion The modified ERAS can be safely applied to the perioperative period of elderly colorectal cancer patients and promote recovery; negative-pressure wound therapy is helpful for wound healing and promoting rehabilitation.
C1 [Liu, Han-Rong; Han, Song; Zhang, Yu; Zhu, Hui-Yin] Tongji Univ, Sch Med, Dept Gen Surg, Shanghai Peoples Hosp 4, 1297 Sanmen Rd, Shanghai, Peoples R China.
   [Yang, Ping] Shanghai Pengpu Community Hlth Serv Ctr, Dept Internal Med, Shanghai, Peoples R China.
C3 Tongji University
RP Liu, HR (通讯作者)，Tongji Univ, Sch Med, Dept Gen Surg, Shanghai Peoples Hosp 4, 1297 Sanmen Rd, Shanghai, Peoples R China.
EM lhr6932@sina.com
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NR 34
TC 7
Z9 7
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD SEP 6
PY 2021
VL 21
IS 1
AR 336
DI 10.1186/s12893-021-01331-y
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UM4LA
UT WOS:000693301900003
PM 34488699
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lempert, M
   Halvachizadeh, S
   Salfelder, CC
   Neuhaus, V
   Pape, HC
   Jukema, GN
AF Lempert, Maximilian
   Halvachizadeh, Sascha
   Salfelder, Clara Charlotte
   Neuhaus, Valentin
   Pape, Hans-Christoph
   Jukema, Gerrolt Nico
TI Long-term experience with a collagen-elastin scaffold in combination
   with split-thickness skin grafts for the treatment of full-thickness
   soft tissue defects: improvements in outcome-a retrospective cohort
   study and case report
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Matriderm (R); Skin grafting; Negative pressure wound therapy (NPWT);
   Bioburden; Full-thickness wounds; Dermal substitute
ID PRESSURE WOUND THERAPY; MATRIDERM; RECONSTRUCTION; EPIDEMIOLOGY;
   SYSTEMS; BURNS
AB Purpose The management of severe soft tissue injuries to the extremities with full-thickness wounds poses a challenge to the patient and surgeon. Dermal substitutes are used increasingly in these defects. The aim of this study was to investigate the impact of the type of injury on the success rate of Matriderm (R) (MD)-augmented split-thickness skin grafting, as well as the role of negative pressure wound therapy (NPWT) in preconditioning of the wounds, with a special focus on the reduction of the bioburden.
   Methods In this study, 45 wounds (44 affecting lower extremities (97.7%)), resulting from different types of injuries: soft tissue (ST), soft tissue complications from closed fracture (F), and open fracture (OF) in 43 patients (age 55.0 +/- 18.2 years, 46.7% female), were treated with the simultaneous application of MD and split-thickness skin grafting. The study was designed as a retrospective cohort study from March 2013 to March 2020. Patients were stratified into three groups: ST, F, and OF. Outcome variables were defined as the recurrence of treated wound defects, which required revision surgery, and the reduction of bioburden in terms of reduction of number of different bacterial strains. For statistical analysis, Student's t-test, analysis of variance (ANOVA), Mann-Whitney U test, and Pearson's chi-squared test were used.
   Results There was no significant difference in the rate of recurrence in the different groups (F: 0%; OF: 11.1%; ST: 9.5%). The duration of VAC therapy significantly differed between the groups (F: 10.8 days; OF: 22.7 days; ST: 12.6 days (p < 0.05)). A clinically significant reduction of bioburden was achieved with NPWT (bacterial shift (mean (SD), F: - 2.25 (1.89); OF: -1.9 (1.37); ST: - 2.6 (2.2)).
   Conclusion MD-augmented split-thickness skin grafting is an appropriate treatment option for full-thickness wounds with take rates of about 90%. The complexity of an injury significantly impacts the duration of the soft tissue treatment but does not have an influence on the take rate. NPWT leads to a relevant reduction of bioburden and is therefore an important part in the preconditioning of full-thickness wounds.
C1 [Lempert, Maximilian; Halvachizadeh, Sascha; Salfelder, Clara Charlotte; Neuhaus, Valentin; Pape, Hans-Christoph; Jukema, Gerrolt Nico] Univ Hosp Zurich, Dept Trauma, Raemistr 100, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Lempert, M (通讯作者)，Univ Hosp Zurich, Dept Trauma, Raemistr 100, CH-8091 Zurich, Switzerland.
EM maximiliam.lempert@usz.ch; sascha.halvachizadeh@usz.ch;
   Clara.salfelder@stud.uni-goettingen.de; valentin.neuhaus@usz.ch;
   hans-christoph.pape@usz.ch; gerroltnico.jukema@usz.ch
OI Pape, Hans-Christoph/0000-0002-2059-4980; Neuhaus,
   Valentin/0000-0003-4012-5628; Lempert, Maximilian/0000-0001-6934-5726
FU Universitat Zurich
FX Open Access funding provided by Universitat Zurich.
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NR 41
TC 6
Z9 6
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD FEB
PY 2022
VL 407
IS 1
BP 327
EP 335
DI 10.1007/s00423-021-02224-7
EA SEP 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ZB5LU
UT WOS:000693343300001
PM 34480629
OA Green Submitted, Green Accepted, hybrid
DA 2026-07-24
ER
PT J
AU Duan, J
   Zhang, CC
   Che, XS
   Fu, JJ
   Pang, F
   Zhao, QG
   You, ZQ
AF Duan, Jing
   Zhang, Chuncheng
   Che, Xiaoshuang
   Fu, Juanjuan
   Pang, Feng
   Zhao, Qigang
   You, Zhiqing
TI Detection of aerobe-anaerobe mixed infection by metagenomic
   next-generation sequencing in an adult suffering from descending
   necrotizing mediastinitis
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Descending necrotizing mediastinitis; mNGS; Aerobe-anaerobe mixed
   infection
ID MANAGEMENT
AB Background Descending necrotizing mediastinitis (DNM) is one of the most virulent forms of mediastinitis. The main causes of high mortality in DNM are believed to stem from difficulty and delay in the diagnosis. Fast and accurate identification of pathogens is important for the treatment of these patients. Metagenomics next-generation sequencing (mNGS) is a powerful tool to identify all kinds of pathogens, especially for rare and complex infections. Case presentation A 64-year-old male patient was admitted to the intensive care unit (ICU) with unconsciousness, dyspnea, and swelling in the mandible and neck. Computed tomography (CT) scan results combined with clinical laboratory examination indicated DNM. Vancomycin and imipenem were used, and vacuum sealing drainage was applied for debridement and drainage of the infected area. The positive mNGS results of drainage fluid confirmed the presence of mixed infection caused by Streptococcus anginosus, Prevotella oris, and several other anaerobes. The antibiotics were adjusted to piperacillin/tazobactam and tinidazole according to the mNGS results and antimicrobial susceptibility testing of cultured pathogens. After 11 days of antibiotic therapy, the infection symptoms of the neck and mediastinum improved, and the patient was transferred out of the ICU on the 26(th) day after negative result of drainage fluid culture. Conclusion This case suggested that mNGS is a promising technology for precise and fast pathogens identification with high sensitivity, which may guide the diagnosis of infectious diseases in the future trend.
C1 [Duan, Jing; Fu, Juanjuan; Pang, Feng; Zhao, Qigang; You, Zhiqing] Liaocheng Peoples Hosp, Dept Clin Lab, 67 Dongchangxi Rd, Liaocheng 252000, Shandong, Peoples R China.
   [Zhang, Chuncheng] Liaocheng Peoples Hosp, Dept Hepatobiliary Surg, 67 Dongchangxi Rd, Liaocheng 252000, Shandong, Peoples R China.
   [Che, Xiaoshuang] Liaocheng Peoples Hosp, Dept Computed Tomog, 67 Dongchangxi Rd, Liaocheng 252000, Shandong, Peoples R China.
RP You, ZQ (通讯作者)，Liaocheng Peoples Hosp, Dept Clin Lab, 67 Dongchangxi Rd, Liaocheng 252000, Shandong, Peoples R China.
EM txt19876@163.com
OI You, Zhiqing/0000-0002-5242-5233; Pang, Feng/0000-0002-7098-0353
FU Medicine and Health Science Technology Development Plan of the Shandong
   Province of China [2016WS0217]
FX The work was supported by the corresponding author of this paper. The
   article-processing and language editing services of this study were
   supported by the Medicine and Health Science Technology Development Plan
   of the Shandong Province of China (Grant Number 2016WS0217).
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NR 15
TC 4
Z9 6
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD SEP 3
PY 2021
VL 21
IS 1
AR 905
DI 10.1186/s12879-021-06624-4
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA UN7ZN
UT WOS:000694229700006
PM 34479479
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Normandin, S
   Safran, T
   Winocour, S
   Chu, CK
   Vorstenbosch, J
   Murphy, AM
   Davison, PG
AF Normandin, Shanel
   Safran, Tyler
   Winocour, Sebastian
   Chu, Carrie K.
   Vorstenbosch, Joshua
   Murphy, Amanda M.
   Davison, Peter G.
TI Negative Pressure Wound Therapy: Mechanism of Action and Clinical
   Applications
SO SEMINARS IN PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; VAC; wounds; semiocclusive membrane
ID VACUUM-ASSISTED CLOSURE; INSTILLATION; TRIAL; FOAM; PROLIFERATION;
   MULTICENTER; ULCERS; IMPACT; DEVICE; SHAPE
AB Negative pressure wound therapy (NPWT) promotes healing by evenly applying negative pressure on the surface of the wound. The system consists of a sponge, a semiocclusive barrier, and a fluid collection system. Its effectiveness is explained by four main mechanisms of action, including macrodeformation of the tissues, drainage of extracellular inflammatory fluids, stabilization of the environment of the wound, and microdeformation. Rarely will complications linked to NPWT occur, but special care must be taken to prevent events such as toxic shock syndrome, fistulization, bleeding, and pain. New NPWT modalities have been recently developed to make NPWT suitable for a wider variety of wounds. These include NPWT with instillation therapy (NPWTi-d), different cleansing options, and application of NPWT on primarily closed incisions. Finally, vacuum-assisted wound closure therapy has been demonstrated to be efficient for various clinical settings, such as the management of diabetic foot ulcers, pressure ulcerations, chronic wounds, and skin grafts.
C1 [Normandin, Shanel] Univ Sherbrooke, Fac Med, Sherbrooke, PQ, Canada.
   [Safran, Tyler; Vorstenbosch, Joshua; Murphy, Amanda M.; Davison, Peter G.] McGill Univ, Div Plast Surg, Montreal, PQ, Canada.
   [Winocour, Sebastian] Baylor Coll Med, Div Plast Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   [Chu, Carrie K.] MD Anderson Canc Ctr, Dept Plast Surg, Houston, TX USA.
C3 University of Sherbrooke; McGill University; Baylor College of Medicine;
   University of Texas System; UTMD Anderson Cancer Center
RP Davison, PG (通讯作者)，McGill Univ, Div Plast & Reconstruct Surg, Dept Surg, Royal Victoria Hosp, 1001 Boul Decarie,Room D02-7007, Montreal, PQ H4A 3J1, Canada.
EM peter.davison@mcgill.ca
RI Vorstenbosch, Joshua/AAH-8339-2021
OI Safran, Tyler/0000-0002-0795-3109
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NR 56
TC 124
Z9 164
U1 6
U2 55
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1535-2188
EI 1536-0067
J9 SEMIN PLAST SURG
JI Semin. Plast. Surg.
PD AUG
PY 2021
VL 35
IS 03
BP 164
EP 170
DI 10.1055/s-0041-1731792
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UO4OS
UT WOS:000694675200007
PM 34526864
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Hannan, E
   Harding, T
   Feizal, H
   Martin, S
AF Hannan, Enda
   Harding, Tim
   Feizal, Hanna
   Martin, Sean
TI Negative pressure wound therapy following excision of pilonidal sinus
   disease: A retrospective review
SO COLORECTAL DISEASE
LA English
DT Review
DE negative pressure wound therapy; pilonidal abscess; pilonidal disease;
   pilonidal sinus; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; GUIDELINES; MANAGEMENT
AB Aim There is no agreed definitive surgical treatment for pilonidal sinus disease (PSD) with several techniques in use with varying success. Negative pressure wound therapy (NPWT) is used to accelerate wound healing but literature in the context of PSD remains sparse. The aim of this study was to evaluate outcomes in patients with PSD treated by a standardised technique of complete surgical excision followed by the application of NPWT. Methods A retrospective observational cohort study of all patients with PSD managed by complete surgical excision followed by application of NPWT was performed over a five year period. The primary endpoints were PSD recurrence and failed wound healing. Results Sixty-one patients underwent treatment during the study period. There was 100% compliance with NPWT. All patients' wounds healed successfully, with the median time to healing being 28 days. One patient (1.6%) developed recurrent PSD and required further surgery. Two patients (3.3%) developed postoperative wound infections. Five patients, who had been managed previously by other operative approaches and subsequently developed recurrence, were successfully managed by this technique. Most patients (52.4%) were managed as a day case procedure. Conclusions Surgery for PSD should have low recurrence rates, prompt wound healing, minimal complications, short inpatient lengths of stay and be tolerated by the patient. Our results demonstrate that our technique meets these criteria. To our knowledge, this study contains the largest number of patients with PSD managed by excision and NPWT in the literature.
C1 [Hannan, Enda; Harding, Tim; Martin, Sean] St Michaels Hosp, Dublin, Ireland.
   [Hannan, Enda; Harding, Tim; Feizal, Hanna; Martin, Sean] St Vincents Univ Hosp, Dublin, Ireland.
C3 University College Dublin; Saint Vincent's University Hospital
RP Hannan, E (通讯作者)，St Michaels Hosp, Dublin, Ireland.
EM endahannan@rcsi.ie
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NR 28
TC 14
Z9 17
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD NOV
PY 2021
VL 23
IS 11
BP 2961
EP 2966
DI 10.1111/codi.15890
EA SEP 2021
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA XM1BD
UT WOS:000695001400001
PM 34455675
DA 2026-07-24
ER
PT J
AU Chaboyer, W
   Ellwood, D
   Thalib, L
   Kumar, S
   Mahomed, K
   Kang, E
   Gillespie, BM
AF Chaboyer, Wendy
   Ellwood, David
   Thalib, Lukman
   Kumar, Sailesh
   Mahomed, Kassam
   Kang, Evelyn
   Gillespie, Brigid M.
TI Incidence and predictors of surgical site infection in women who are
   obese and give birth by elective caesarean section: A secondary analysis
SO AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
LA English
DT Article
DE caesarean section; obesity; risk factor; surgical site infection; wound
   complication
ID RISK-FACTORS; INCISION
AB Background Surgical site infection (SSI) after a caesarean section is of concern (CS) is of concern to both clinicians and women themselves. Aims The aim of this study is to identify the cumulative incidence and predictors of SSI in women who are obese and give birth by elective CS. Materials and Methods The method used was planned secondary analysis of data from women with a pre-pregnancy body mass index (BMI) >= 30 kg/m(2) giving birth by elective CS in a multicentre randomised controlled trial of a prophylactic closed-incision negative pressure wound therapy dressing. Data were collected from medical records, direct observations of the surgical site and self-reported signs and symptoms from October 2015 to December 2019. The Centers for Disease Control and Prevention definition was used to identify SSI. Women were followed up once in hospital just before discharge and then weekly for four weeks after discharge. Blinded outcome assessors determined SSI. After the cumulative incidence of SSI was calculated, multiple variable logistic regression models were used to identify independent risk factors for SSI. Results SSI incidence in 1459 women was 8.4% (122/1459). Multiple variable-adjusted odds ratios (OR) for SSI were BMI >= 40 kg/m(2) (OR 1.55, 95% confidence interval (CI) 1.30-1.86) as compared to BMI 30-34.9 0 kg/m(2), >= 2 previous pregnancies (OR 1.38, 95% CI 1.00-1.80) as compared to no previous pregnancies and pre-CS vaginal cleansing (OR 0.55, 95% CI 0.33-0.99). Conclusions Our findings may inform preoperative counselling and shared decision-making regarding planned elective CS for women with pre-pregnancy BMI >= 30 kg/m(2).
C1 [Chaboyer, Wendy; Gillespie, Brigid M.] Griffith Univ, NHMRC Ctr Res Excellence Wiser Wound Care, Gold Coast, Qld 4222, Australia.
   [Chaboyer, Wendy; Gillespie, Brigid M.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Qld 4222, Australia.
   [Ellwood, David] Griffith Univ, Gold Coast Univ Hosp, Sch Med, Gold Coast, Qld, Australia.
   [Thalib, Lukman] Istanbul Aydin Univ, Fac Med, Dept Biostat, Istanbul, Turkey.
   [Kumar, Sailesh] Univ Queensland, Fac Med, Dept Obstet & Gynaecol, Brisbane, Qld, Australia.
   [Kumar, Sailesh] Mater Mothers Hosp, Brisbane, Qld, Australia.
   [Mahomed, Kassam] Univ Queensland, Ipswich Hosp, Dept Obstet & Gynaecol, Ipswich, Qld, Australia.
   [Mahomed, Kassam] Univ Queensland, Ipswich Hosp, Fac Med, Ipswich, Qld, Australia.
   [Kang, Evelyn] Griffith Univ, Menzies Hlth Inst Queensland, Sch Nursing & Midwifery, Gold Coast, Qld, Australia.
   [Gillespie, Brigid M.] Griffith Univ, Gold Coast Univ Hosp, Gold Coast, Qld, Australia.
C3 Griffith University; Menzies Health Institute Queensland; Griffith
   University; Griffith University; Gold Coast University Hospital;
   Istanbul Aydin University; University of Queensland; Mater Health
   Services; Mater Mothers' Hospital; University of Queensland; University
   of Queensland; Menzies Health Institute Queensland; Griffith University;
   Griffith University; Gold Coast University Hospital
RP Chaboyer, W (通讯作者)，Griffith Univ, NHMRC Ctr Res Excellence Wiser Wound Care, Gold Coast, Qld 4222, Australia.; Chaboyer, W (通讯作者)，Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Qld 4222, Australia.
EM w.chaboyer@griffith.edu.au
RI ; Ellwood, David/C-8208-2015; Thalib, Lukman/HAI-7553-2022; Chaboyer,
   Wendy/F-9588-2018; Kumar, Sailesh/M-3207-2014; Mahomed,
   Kassam/M-1335-2013; Gillespie, Brigid/E-7799-2012
OI Kang, Evelyn/0000-0001-8253-1638; Ellwood, David/0000-0003-4512-6443;
   Thalib, Lukman/0000-0002-1211-6495; Chaboyer, Wendy/0000-0001-9528-7814;
   Kumar, Sailesh/0000-0003-0832-4811; Gillespie,
   Brigid/0000-0003-3186-5691
FU National Health and Medical Research Council [APP1081026]
FX We thank Nicky Cullum, Joan Webster and Jennifer Whitty for their
   contribution as chief investigators of the parent trial. National Health
   and Medical Research Council project grant APP1081026 $2,285,351.
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NR 33
TC 5
Z9 6
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0004-8666
EI 1479-828X
J9 AUST NZ J OBSTET GYN
JI Aust. N. Z. J. Obstet. Gynaecol.
PD APR
PY 2022
VL 62
IS 2
BP 234
EP 240
DI 10.1111/ajo.13428
EA SEP 2021
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 0V3KL
UT WOS:000695012300001
PM 34506037
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Myllykangas, HM
   Halonen, J
   Husso, A
   Väänänen, H
   Berg, LT
AF Myllykangas, Heidi-Mari
   Halonen, Jari
   Husso, Annastiina
   Vaananen, Helli
   Berg, Leena T.
TI Does Incisional Negative Pressure Wound Therapy Prevent Sternal Wound
   Infections?
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE CABG; sternum; surgery; complications; wound healing; wound infection
ID CARDIAC-SURGERY; MANAGEMENT; SYSTEM; IMPACT
AB Background Incisional negative pressure wound therapy has been described as an effective method to prevent wound infections after open heart surgery in several publications. However, most studies have examined relatively small patient groups, only a few were randomized, and some have manufacturer-sponsorship. Most of the studies have utilized Prevena; there are only a few reports describing the PICO incisional negative pressure wound therapy system.
   Methods We conducted a prospective cohort study involving a propensity score-matched analysis to evaluate the effect of PICO incisional negative pressure wound therapy after coronary artery bypass grafting. A total of 180 high-risk patients with obesity or diabetes were included in the study group. The control group included 772 high-risk patients operated before the initiation of the study protocol.
   Results The rates of deep sternal wound infections in the PICO group and in the control group were 3.9 and 3.1%, respectively. The rates of superficial wound infections needing operative treatment were 3.1 and 0.8%, respectively. After propensity score matching with two groups of 174 patients, the incidence of both deep and superficial infections remained slightly elevated in the PICO group. None of the infections were due to technical difficulties or early interruption of the treatment.
   Conclusion It seems that incisional negative pressure wound therapy with PICO is not effective in preventing wound infections after coronary artery bypass grafting. The main difference in this study compared with previous reports is the relatively low incidence of infections in our control group.
C1 [Myllykangas, Heidi-Mari; Vaananen, Helli] Kuopio Univ Hosp, Dept Plast Surg, PL 100, Kuopio 70029, Finland.
   [Myllykangas, Heidi-Mari; Halonen, Jari] Univ Eastern Finland, Sch Med, Kuopio, Pohjois Savo, Finland.
   [Halonen, Jari; Husso, Annastiina] Kuopio Univ Hosp, Dept Cardiothorac Surg, Kuopio, Pohjois Savo, Finland.
   [Berg, Leena T.] Kainuu Cent Hosp, Dept Plast Surg, Kajaani, Kainuu, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland; University of Eastern Finland Hospital; Kuopio
   University Hospital
RP Myllykangas, HM (通讯作者)，Kuopio Univ Hosp, Dept Plast Surg, PL 100, Kuopio 70029, Finland.
EM heidi.myllykangas@kuh.fi
RI Halonen, Jari/K-9329-2018
OI Myllykangas, Heidi-Mari/0000-0003-0542-987X
FU Orion Research Foundation; Oiva Vaittinen fund
FX This study was supported by the Orion Research Foundation and Oiva
   Vaittinen fund. Authors want to thank Tuomas Selander for his assistance
   with the statistical analysis.
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NR 30
TC 6
Z9 7
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD JAN
PY 2022
VL 70
IS 01
BP 65
EP 71
DI 10.1055/s-0041-1731767
EA SEP 2021
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA YW0TU
UT WOS:000695677300008
PM 34521138
DA 2026-07-24
ER
PT J
AU Kirsner, RS
   Zimnitsky, D
   Robinson, M
AF Kirsner, Robert S.
   Zimnitsky, Dmitry
   Robinson, Michael
TI A prospective, randomized, controlled clinical study on the
   effectiveness of a single-use negative pressure wound therapy system,
   compared to traditional negative pressure wound therapy in the treatment
   of diabetic ulcers of the lower extremities
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID EVIDENCE-BASED RECOMMENDATIONS; STEPS
AB A multicenter, phase 4, randomized, comparative-efficacy study in subjects with lower extremity wounds was carried out to compare wound closure rates, for a single-use negative pressure wound therapy (s-NPWT) versus traditional NPWT (t-NPWT) systems over a 12-week treatment period. From the initial population of patients with diabetic foot ulcers (DFU) and venous leg ulcers (VLU), we analyzed a subgroup of patients with diabetes mellitus and leg and foot ulcers (either DFUs or VLUs in diabetics), termed, the diabetic lower extremity ulcers (DLEU). In the DLEU group, there were 95 patients in intention-to-treat (ITT) and 61 patients in per protocol (PP) populations, respectively. We found a significant difference in favor of s-NPWT over t-NPWT in the confirmed wound closures at 12 weeks both in ITT (p < 0.001) and PP populations (p = 0.017). Significantly higher wound closure rates in s-NPWT group suggest that s-NPWT should be preferred NPWT option for DLEU.
C1 [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
   [Zimnitsky, Dmitry] Smith Nephew, Global Clin Strategy, Cary, NC USA.
   [Robinson, Michael] Smith Nephew, Global Data Analyt, Kingston Upon Hull, N Humberside, England.
C3 University of Miami; Smith & Nephew
RP Kirsner, RS (通讯作者)，Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
EM rkirsner@med.miami.edu
FU Smith+Nephew
FX This study was sponsored by Smith+Nephew.
CR Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
   Brownhill VR, 2021, ADV WOUND CARE, V10, P345, DOI 10.1089/wound.2020.1218
   Delhougne G, 2018, OSTOMY WOUND MANAG, V64, P26
   Driscoll P., 2013, MEDILIGENCE
   Galiano RD, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001560
   Hingorani A, 2016, J VASC SURG, V63, p3S, DOI 10.1016/j.jvs.2015.10.003
   Hurd T, 2014, OSTOMY WOUND MANAG, V60, P30
   Hyldig N, 2019, BJOG-INT J OBSTET GY, V126, P628, DOI 10.1111/1471-0528.15413
   Kirsner R, 2019, WOUND REPAIR REGEN, V27, P519, DOI 10.1111/wrr.12727
   Malmsjo Malin, 2014, Eplasty, V14, pe15
   McCluskey Pat, 2020, Journal of Community Nursing, V34, P36
   Mosti G, 2020, J CLIN MED, V9, DOI 10.3390/jcm9113709
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   Styche, 2017, WOUNDS INT, V8, P52
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NR 15
TC 9
Z9 13
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV
PY 2021
VL 29
IS 6
BP 908
EP 911
DI 10.1111/wrr.12966
EA SEP 2021
PG 4
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA WS3HE
UT WOS:000696012300001
PM 34525239
DA 2026-07-24
ER
PT J
AU Cannata, A
   Ordanini, M
   Sesana, G
   Russo, CF
AF Cannata, Aldo
   Ordanini, Marco
   Sesana, Giovanni
   Russo, Claudio Francesco
TI Nonoperative Management of a Recurrent Postoperative Inguinal Lymphatic
   Leak via Negative-Pressure Wound Therapy: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE cardiac; femoral vessels; lymphatic leak; negative-pressure wound
   therapy; NPWT; postoperative complication; surgery; vascular
AB Lymphatic leaks are common following common femoral vessel exposure for cardiac surgical procedures. The management of this complication can be difficult and is often uncomfortable for the patient. This case report describes the successful nonoperative treatment of a recurrent lymphatic leak from an inguinal surgical wound via negative-pressure wound therapy. Negative pressure may be considered a minimally invasive, effective, and acceptable way to treat postoperative lymphatic leaks at the groin.
C1 [Cannata, Aldo] Osped Niguarda Ca Granda, Milan, Italy.
   [Ordanini, Marco; Russo, Claudio Francesco] Dept Cardiac Surg, Milan, Italy.
   [Sesana, Giovanni; Russo, Claudio Francesco] Wound Healing Ctr, Cleveland, OH USA.
C3 Ospedale Niguarda Ca' Granda; IRCCS Ca Granda Ospedale Maggiore
   Policlinico
RP Cannata, A (通讯作者)，Osped Niguarda Ca Granda, Milan, Italy.
OI Russo, Claudio Francesco/0000-0001-5439-1420
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   Tauber R, 2013, J PLAST RECONSTR AES, V66, P390, DOI 10.1016/j.bjps.2012.09.030
   Uhl C, 2020, ANN VASC SURG, V62, P382, DOI 10.1016/j.avsg.2019.06.011
   Van den Brande P, 2012, ANN VASC SURG, V26, P833, DOI 10.1016/j.avsg.2012.02.009
   Yuan Y, 2019, J SURG RES, V235, P329, DOI 10.1016/j.jss.2018.09.065
NR 10
TC 1
Z9 1
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD OCT
PY 2021
VL 34
IS 10
DI 10.1097/01.ASW.0000775928.63723.3b
PG 3
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA US3QW
UT WOS:000697349000001
PM 34546209
DA 2026-07-24
ER
PT J
AU Timmermans, FW
   Mokken, SE
   Smit, JM
   Zwanenburg, PR
   van Hout, N
   Bouman, MB
   Middelkoop, E
   Mullender, MG
AF Timmermans, F. W.
   Mokken, S. E.
   Smit, J. M.
   Zwanenburg, P. R.
   van Hout, N.
   Bouman, M. B.
   Middelkoop, E.
   Mullender, M. G.
TI Within-patient randomized clinical trial comparing incisional
   negative-pressure wound therapy with suction drains in gender-affirming
   mastectomies
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Article
ID TO-MALE TRANSSEXUALS; WALL CONTOURING SURGERY; DEAD SPACE; MANAGEMENT;
   CLOSURE; TRANSGENDER; OUTCOMES
AB Background: Incisional negative-pressure wound therapy (iNPWT) is widely adopted by different disciplines for multiple indications. Questions about the most appropriate uses and value of iNPWT have been raised.
   Methods: An open-label within-patient RCT was conducted in transgender men undergoing gender-affirming mastectomies. The objective was to determine the effect of iNPWT as a substitute for standard dressing and suction drains on wound healing complications. One chest side was randomized to receive the iNPWT intervention, and the other to standard dressing with suction drain. The primary endpoints were wound healing complications (haematoma, seroma, infection, and dehiscence) after three months. Additional outcomes were pain according to a numerical rating scale and patient satisfaction one week after surgery.
   Results: Eighty-five patients were included, of whom 81 received both the iNPWT and standard treatment. Drain removal criteria were met within 24h in 95 per cent of the patients. No significant decrease in wound healing complications was registered on the iNPWT side, but the seroma rate was significantly increased. In contrast, patients experienced both significantly less pain and increased comfort on the iNPWT side. No medical device-related adverse events were registered.
   Conclusion: Substituting short-term suction drains with iNPWT in gender-affirming mastectomies increased the seroma rates and did not decrease the amount of wound healing complications.
C1 [Timmermans, F. W.; Mokken, S. E.; Smit, J. M.; Zwanenburg, P. R.; van Hout, N.; Bouman, M. B.; Middelkoop, E.; Mullender, M. G.] Vrije Univ Amsterdam, Dept Plast Reconstruct & Hand Surg, Amsterdam Movement Sci, Amsterdam UMC, Amsterdam, Netherlands.
   [Timmermans, F. W.; Mokken, S. E.; Smit, J. M.; van Hout, N.; Bouman, M. B.; Mullender, M. G.] Vrije Univ Amsterdam, Ctr Expertise Gender Dysphoria, Amsterdam UMC, Amsterdam, Netherlands.
   [Mokken, S. E.; Bouman, M. B.; Mullender, M. G.] Vrije Univ Amsterdam, Dept Plast Reconstruct & Hand Surg, Amsterdam Publ Hlth, Amsterdam UMC, Amsterdam, Netherlands.
   [Smit, J. M.; Zwanenburg, P. R.; van Hout, N.; Bouman, M. B.; Mullender, M. G.] Amsterdam Med Ctr, Dept Plast Reconstruct & Hand Surg, Amsterdam UMC, Amsterdam, Netherlands.
   [Middelkoop, E.] Red Cross Hosp, Assoc Dutch Burn Ctr, Beverwijk, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; University of
   Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam;
   University of Amsterdam; University of Amsterdam; Academic Medical
   Center Amsterdam
RP Timmermans, FW (通讯作者)，Amsterdam UMC Locat VUmc, Dept Plast Reconstruct & Hand Surg, De Boelelaan 1117, Amsterdam, Netherlands.
EM f.timmermans@amsterdamumc.nl
RI ; Mullender, Margriet/PWH-3332-2026; Middelkoop, Esther/M-3735-2014
OI Mokken, Sterre/0000-0002-8891-969X; Mullender,
   Margriet/0000-0001-6407-5405; Bouman, Mark-Bram/0000-0002-4245-783X;
   Middelkoop, Esther/0000-0001-8843-1080
CR Abesamis GM, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002141
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   Baker E, 2017, SURG-J R COLL SURG E, V15, P267, DOI 10.1016/j.surge.2015.12.007
   Cagney D, 2020, WORLD J SURG, V44, P1526, DOI 10.1007/s00268-019-05335-x
   Coleman E, 2012, INT J TRANSGENDERISM, V13, P165, DOI 10.1080/15532739.2011.700873
   Fang CL, 2020, INT WOUND J, V17, P326, DOI 10.1111/iwj.13273
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   Gabriel A, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001880
   Galiano RD, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001560
   Gallagher S, 2019, ANN PLAS SURG, V83, P15, DOI 10.1097/SAP.0000000000001810
   Granzier RWY, 2019, BREAST, V46, P81, DOI 10.1016/j.breast.2019.05.002
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   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
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NR 39
TC 5
Z9 5
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD AUG
PY 2021
VL 108
IS 8
BP 925
EP 933
DI 10.1093/bjs/znab204
EA JUL 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA US4BV
UT WOS:000697377700030
PM 34244715
OA Green Submitted, Green Published, Bronze
DA 2026-07-24
ER
PT J
AU Chicco, M
   Huang, TCT
   Cheng, HT
AF Chicco, Maria
   Huang, Tony Chieh-Ting
   Cheng, Hsu-Tang
TI Negative-Pressure Wound Therapy in the Prevention and Management of
   Complications From Prosthetic Breast Reconstruction A Systematic Review
   and Meta-analysis
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT 29th Conference of the European-Wound-Management-Association
CY JUN 05-07, 2019
CL Gothenburg, SWEDEN
SP European Wound Management Assoc
DE negative pressure wound therapy; prosthetic breast reconstruction;
   prosthesis-related complication
ID IMPLANT; SALVAGE; EXPANDER
AB Background Complications from prosthetic breast reconstruction are distressing for patients, and their management is challenging. For decades, negative-pressure wound therapy (NPWT) has been successfully used for the closure of complex wounds. This study analyzes the outcomes of NPWT use in the prevention and management of complications from prosthetic breast reconstruction. Method A systematic search of studies published until August 2020 was conducted using the PubMed/MEDLINE, EMBASE, and Ebscohost/CINAHL databases and using the following key words: "negative-pressure wound therapy," "breast reconstruction," and "prosthesis" (including breast implants and tissue expanders). Analyzed endpoints were outcomes of NPWT use in prosthetic breast reconstruction compared with conventional dressings. The methodological quality of included studies was assessed independently. Comparative studies were further meta-analyzed to obtain pooled odds ratios (ORs) describing the effectiveness of NPWT in prosthetic breast reconstruction. Results/Discussion Ten studies were included with a total of 787 patients (1230 breasts) undergoing prosthetic breast reconstruction with breast implants or tissue expanders. Three case-control studies focused on preventing breast wound complications. The meta-analysis of the 3 studies included 502 breasts receiving NPWT and 698 breasts receiving conventional wound care. The meta-analysis favored NPWT for less mastectomy flap necrosis (5.6% vs 14.3%; OR, 0.46; 95% confidence interval, 0.27 -0.77; P = 0.004; I-2 = 0%) and less overall wound complications (10.6% vs 21.1%; OR, 0.49; 95% confidence interval, 0.35-0.70; P < 0.00001; I-2 = 0%). In the management of nipple-areolar complex venous congestion, 1 case report demonstrated 85% rescue of nipple-areolar complex after using NPWT (-75 mm Hg) for a total of 12 days. In the management of periprosthetic infections, 2 case series used NPWT with instillation. It accelerated the treatment of infection and maintained the breast cavity for future reconstruction. Conventional NPWT also showed good salvage outcome in four studies. Conclusions Current evidence suggests that prophylactic use of NPWT in prosthetic breast reconstruction reduces the rate of overall wound complications and mastectomy flap necrosis. In the management of complications from prosthetic breast reconstructions, NPWT may be a promising option showing beneficial results. Additional high-quality trials are warranted to corroborate the findings of this systematic review.
C1 [Chicco, Maria] Frimley Hlth NHS Fdn Must, Dept Plast & Reconstruct Seger, Wexham Pk Hosp, Slough, Berks, England.
   [Huang, Tony Chieh-Ting] Mayo Clin, Div Plast & Reconstruct Surg, Rochester, MN USA.
   [Cheng, Hsu-Tang] Asia Univ, Asia Univ Hosp, Dept Surg, Div Plast & Reconstruct Surg,Coll Med & Hlth Sci, 222 Fuxin Rd, Taichung 41354, Taiwan.
   [Cheng, Hsu-Tang] China Med Univ Hosp, Big Data Ctr, Taichung, Taiwan.
C3 Mayo Clinic; Asia University Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan
RP Cheng, HT (通讯作者)，Asia Univ, Asia Univ Hosp, Dept Surg, Div Plast & Reconstruct Surg,Coll Med & Hlth Sci, 222 Fuxin Rd, Taichung 41354, Taiwan.
EM hsutangcheng@gmail.com
FU Asia University Hospital Research Program [10851006]; Asia University
   and Asia University Hospital Joint Research Program [ASIA-107-AUH-09];
   China Medical University Hospital Joint Research Program
   [ASIA-108-CMUH-23]; Asia University
FX This study is supported in part by Asia University Hospital Research
   Program (10851006), Asia University and Asia University Hospital Joint
   Research Program (ASIA-107-AUH-09), and Asia University and China
   Medical University Hospital Joint Research Program (ASIA-108-CMUH-23).
CR Accurso A, 2017, AESTHET PLAST SURG, V41, P36, DOI 10.1007/s00266-016-0739-1
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NR 21
TC 13
Z9 17
U1 2
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2021
VL 87
IS 4
BP 478
EP 483
DI 10.1097/SAP.0000000000002722
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA UU4BB
UT WOS:000698742600031
PM 34060773
DA 2026-07-24
ER
PT J
AU Saeg, F
   Schoenbrunner, AR
   Janis, JE
AF Saeg, Fouad
   Schoenbrunner, Anna R.
   Janis, Jeffrey E.
TI Evidence-Based Wound Irrigation: Separating Fact from Fiction
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID AESTHETIC BREAST AUGMENTATION; CAPSULAR CONTRACTURE; ANTIBIOTIC
   IRRIGATION; COMPLEX WOUNDS; THERAPY; EFFICACY; INSTILLATION; RISK;
   RECOMMENDATIONS; DEBRIDEMENT
AB The relationship between wound irrigation and healing has been recognized for centuries. However, there is little evidence and no official recommendations from any health care organization regarding best wound irrigation practices. This is the first review of wound irrigation that systematically summarizes the literature using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and distills the evidence into a practical format. In this comprehensive review, the authors outline the irrigation fluids and delivery methods used in the identified studies, analyze reported treatment outcomes, summarize irrigation effectiveness, and propose evidence-based guidelines to improve wound healing outcomes and enhance the consistency of wound irrigation. Thirty-one high-quality studies with a combined total of 61,808 patients were included. Based on the current evidence provided by this review, the authors propose the following guidelines: (1) acute soft-tissue wounds should receive continuous gravity flow irrigation with polyhexanide; (2) complex wounds should receive continuous negative-pressure wound therapy with instillation with polyhexanide; (3) infected wounds should receive continuous negative-pressure wound therapy with instillation with silver nitrate, polyhexanide, acetic acid, or povidone-iodine; (4) breast implant wounds should receive gravity lavage with povidone-iodine or antibiotics; and (5) surgical-site infection rates can be reduced with intraoperative povidone-iodine irrigation.
C1 Tulane Univ, Sch Med, New Orleans, LA 70118 USA.
   [Janis, Jeffrey E.] Ohio State Univ, Dept Plast & Reconstruct Surg, Wexner Med Ctr, 915 Olentangy River Rd, Columbus, OH 43212 USA.
C3 Tulane University; University System of Ohio; Ohio State University
RP Janis, JE (通讯作者)，Ohio State Univ, Dept Plast & Reconstruct Surg, Wexner Med Ctr, 915 Olentangy River Rd, Columbus, OH 43212 USA.
EM jeffrey.janis@osumc.edu
RI Janis, Jeffrey/W-6760-2019
OI Saeg, Fouad/0000-0003-3617-120X
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NR 44
TC 21
Z9 27
U1 1
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2021
VL 148
IS 4
BP 601E
EP 614E
DI 10.1097/PRS.0000000000008331
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UU4JS
UT WOS:000698767600009
PM 34415884
DA 2026-07-24
ER
PT J
AU Creta, M
   Sica, A
   Napolitano, L
   Celentano, G
   La Rocca, R
   Capece, M
   Calogero, A
   Califano, G
   Vanni, L
   Mangiapia, F
   Arcaniolo, D
   Spirito, L
   Fusco, F
   De Sio, M
   Imbimbo, C
   Mirone, V
   Sagnelli, C
   Longo, N
AF Creta, Massimiliano
   Sica, Antonello
   Napolitano, Luigi
   Celentano, Giuseppe
   La Rocca, Roberto
   Capece, Marco
   Calogero, Armando
   Califano, Gianluigi
   Vanni, Luigi
   Mangiapia, Francesco
   Arcaniolo, Davide
   Spirito, Lorenzo
   Fusco, Ferdinando
   De Sio, Marco
   Imbimbo, Ciro
   Mirone, Vincenzo
   Sagnelli, Caterina
   Longo, Nicola
TI Fournier's Gangrene in Patients with Oncohematological Diseases: A
   Systematic Review of Published Cases
SO HEALTHCARE
LA English
DT Review
DE Fournier's gangrene; necrotizing fasciitis; oncohematology
ID ACUTE PROMYELOCYTIC LEUKEMIA; HYPERBARIC-OXYGEN THERAPY; NECROTIZING
   FASCIITIS; PSEUDOMONAS-AERUGINOSA; CASE SERIES; MORTALITY; INFECTION;
   CHILDREN; SCROTUM; PENIS
AB Patients suffering from hematological malignancies are at increased risk of Fournier's gangrene (FG) due to immunosuppression caused by the disease itself or by disease-related treatments. A systematic review of PubMed, ISI Web of Knowledge, and Scopus databases was performed in June 2021. We included full papers that met the following criteria: original research, human studies, and describing clinical presentation, treatment, and outcomes of FG in patients with oncohematological diseases. We identified 35 papers published from 1983 to 2021 involving 44 patients (34 males, 8 females) aged between 4 days and 83 years. The most common malignant hematological disorders were acute myeloid leukemia (n = 21) and acute lymphocytic leukemia (n = 9). In 10 patients FG represented the first presentation of hematological malignancy. Scrotum (n= 27) and perineum (n =11) were the sites most commonly involved. Pseudomonas aeruginosa (n = 21) and Escherichia coli (n = 6) were the most commonly isolated microorganisms. Surgery was performed in 39 patients. Vacuum-assisted closure and hyperbaric oxygen therapy were adopted in 4 and in 3 patients, respectively. Recovery was achieved in 30 patients. FG-related mortality was observed in 11 patients. FG should be carefully considered in patients with oncohematological diseases.
C1 [Creta, Massimiliano; Napolitano, Luigi; Celentano, Giuseppe; La Rocca, Roberto; Capece, Marco; Califano, Gianluigi; Mangiapia, Francesco; Spirito, Lorenzo; Imbimbo, Ciro; Mirone, Vincenzo; Longo, Nicola] Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, I-80130 Naples, Italy.
   [Sica, Antonello] Univ Campania Luigi Vanvitelli, Dept Precis Med, I-80123 Naples, Italy.
   [Calogero, Armando] Univ Naples Federico II, Dept Adv Biomed Sci, I-80130 Naples, Italy.
   [Vanni, Luigi] Univ Naples Federico II, Dept Publ Hlth, I-80130 Naples, Italy.
   [Arcaniolo, Davide; Fusco, Ferdinando; De Sio, Marco] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Urol Unit, I-81100 Naples, Italy.
   [Sagnelli, Caterina] Univ Campania Luigi Vanvitelli, Dept Mental Hlth & Publ Med, I-80131 Naples, Italy.
C3 University of Naples Federico II; Universita della Campania Vanvitelli;
   University of Naples Federico II; University of Naples Federico II;
   Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli
RP Creta, M (通讯作者)，Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, I-80130 Naples, Italy.
EM massimiliano.creta@unina.it; antonello.sica@fastwebnet.it;
   luiginap89@gmail.com; dr.giuseppecelentano@gmail.com;
   roberto.larocca@unina.it; drmarcocapece@gmail.com;
   armando.calogero2@unina.it; gianl.califano2@gmail.com;
   luigi.vanni@libero.it; mangiapippo@libero.it;
   davide.arcaniolo@gmail.com; lorenzospirito@msn.com;
   ferdinandolusco@unicampania.it; marco.desio@unicampania.it;
   ciro.imbimbo@unina.it; mirone@unina.it;
   caterina.sagnelli@unicampania.it; nicola.longo@unina.it
RI De Sio, Marco/AAA-6330-2021; Creta, Massimiliano/K-2971-2016;
   Napolitano, Luigi/GLU-7753-2022; Sagnelli, Caterina/K-9338-2016; SICA,
   ANTONELLO/AAS-4471-2021
OI De Sio, Marco/0000-0003-0820-6030; Creta,
   Massimiliano/0000-0003-2082-3330; Califano,
   Gianluigi/0000-0002-2225-5683; Napolitano, Luigi/0000-0003-2036-0356;
   Sagnelli, Caterina/0000-0002-6413-7810; Arcaniolo,
   Davide/0000-0002-5282-2335; Celentano, Giuseppe/0000-0002-3346-8385;
   Longo, Nicola/0009-0009-3394-0596; Capece, Marco/0000-0002-1951-404X;
   Spirito, Lorenzo/0000-0003-1175-8637
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NR 50
TC 13
Z9 14
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD SEP
PY 2021
VL 9
IS 9
AR 1123
DI 10.3390/healthcare9091123
PG 20
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA UV5CN
UT WOS:000699496400001
PM 34574898
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Demir, M
   Yagmur, I
   Kati, B
   Pelit, ES
   Tunçekin, A
   Ciftçi, H
AF Demir, Mehmet
   Yagmur, Ismail
   Kati, Bulent
   Pelit, Eyyup Sabri
   Tuncekin, Adem
   Ciftci, Halil
TI Evaluation of the effectiveness of vacuum-assisted closure in the
   treatment of Fournier gangrene
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE Fournier gangrene; Debridement; Vacuum-assisted closure; Wound therapy;
   Mortality
ID PROGNOSTIC-FACTORS; WOUND THERAPY; OUTCOMES; EXPERIENCE; MANAGEMENT
AB Background and objective: To evaluate the effectiveness of vacuum-assisted closure (VAC) in the treatment of Fournier gangrene (FG). Material and methods: Forty-eight male patients treated for Fournier gangrene were included in the study. The patients were divided into two groups (Group I: conventional dressing, Group II: VAC therapy). Characteristics of the patients, laboratory parameters, number of debridement procedures, daily number of dressings, visual analogue scale (VAS) during dressing, analgesic requirement, colostomy requirement, time from the first debridement to wound closure, wound closure method, length of hospital stay, and mortality rates were compared. Results: Group I comprised 33 patients and Group II comprised 15 patients. The number of dressings, VAS score and daily analgesic requirement were statistically significantly lower in Group II (p 0.05) than in Group I. The number of debridement procedures, colostomy requirement, orchiectomy rate, time from first debridement to wound closure, length of hospital stay, wound closure method and mortality rate were similar between these two groups (p 0.05). Conclusion: The clinical results of conventional dressing and VAC therapy were similar for treating FG. VAC therapy is an effective postoperative wound care method that offers less requirement for dressing changes, less pain, less analgesic requirement and more patient satisfaction compared to conventional dressing.
C1 [Demir, Mehmet; Yagmur, Ismail; Kati, Bulent; Pelit, Eyyup Sabri; Tuncekin, Adem; Ciftci, Halil] Harran Univ, Dept Urol, TR-63500 Sanliurfa, Turkey.
C3 Harran University
RP Demir, M (通讯作者)，Harran Univ, Dept Urol, TR-63500 Sanliurfa, Turkey.
EM drdemir02@gmail.com
RI Tunçekin, Adem/HCH-8358-2022; yağmur, ismail/ABF-7274-2020;
   /ABF-3298-2020; /ABI-1129-2020; Kati, Bulent/AGQ-3954-2022; Demir,
   Mehmet/ABF-4150-2020
OI Tunçekin, Adem/0000-0001-9951-2556; 
CR BARKEL DC, 1986, AM SURGEON, V52, P395
   Chawla SN, 2003, EUR UROL, V43, P572, DOI 10.1016/S0302-2838(03)00102-7
   Cuccia G, 2009, UROL INT, V82, P426, DOI 10.1159/000218532
   Czymek R, 2010, LANGENBECK ARCH SURG, V395, P173, DOI 10.1007/s00423-008-0461-9
   Eke N, 2000, BJS-BRIT J SURG, V87, P718, DOI 10.1046/j.1365-2168.2000.01497.x
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NR 28
TC 0
Z9 0
U1 0
U2 2
PU MRE PRESS
PI SINGAPORE
PA 14 ROBINSON RD #08-01A FAR EAST FINANCE, SINGAPORE, SINGAPORE
SN 1875-6867
EI 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PD SEP
PY 2021
VL 17
IS 4
BP 304
EP 309
DI 10.31083/jomh.2021.089
EA AUG 2021
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA WD5UM
UT WOS:000699929200001
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, RU
   Zeng, CJ
   Yuan, S
   Chen, YR
   Zhao, SW
   Ren, GH
AF Li, Runguang
   Zeng, Canjun
   Yuan, Song
   Chen, Yirong
   Zhao, Shanwen
   Ren, Gao-hong
TI Free flap transplantation combined with Ilizarov bone transport for the
   treatment of severe composite tibial and soft tissue defects
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Free flap transplantation; Ilizarov bone transport; soft tissue defect;
   open fracture; clinical efficacy; functional outcome
ID VACUUM SEALING DRAINAGE; EXTERNAL FIXATION; ORTHOFIX LRS;
   RECONSTRUCTION; OSTEOMYELITIS; OUTCOMES; FIBULA
AB Objective
   To evaluate the clinical efficacy of free flap transplantation combined with Ilizarov bone transport in the treatment of severe composite tibial and soft tissue defects.
   Methods
   We retrospectively analyzed the clinical data of 40 patients with severe composite tibial and soft tissue defects who underwent free flap transplantation combined with Ilizarov bone transport. The clinical efficacy was evaluated according to the following criteria: success rate of wound repair by free flap transplantation, incidence or recurrence rate of deep infection, healing rate of bone defects and external fixation index, incidence of complications, and functional score of affected extremities.
   Results
   All infections were generally well controlled by radical debridement and negative-pressure therapy, and all 40 patients' wounds healed after repair and reconstruction of the tibia and soft tissues. Postoperative complications were alleviated by active treatment. The mean external fixation time was 12.83 +/- 2.85 months, and the external fixation index was 1.55 m/cm. According to the Association for the Study and Application of Methods of Ilizarov (ASAMI) score, an excellent or good functional outcome was attained in 85% of patients.
   Conclusion
   Free flap transplantation combined with Ilizarov bone transport is an effective treatment for severe composite tibial and soft tissue defects.
C1 [Li, Runguang; Zeng, Canjun; Zhao, Shanwen] Southern Med Univ, Affiliated Hosp 3, Ctr Orthopaed Surg, Dept Foot & Ankle Surg, Guangzhou, Peoples R China.
   [Li, Runguang; Zeng, Canjun; Zhao, Shanwen] Orthopaed Hosp Guangdong Prov, Guangzhou, Peoples R China.
   [Li, Runguang; Zeng, Canjun; Zhao, Shanwen] Acad Orthopaed, Guangzhou, Guangdong, Peoples R China.
   [Li, Runguang; Zeng, Canjun; Zhao, Shanwen] Guangdong Prov Key Lab Bone & Joint Degenerat Dis, Guangzhou, Peoples R China.
   [Li, Runguang; Yuan, Song] Linzhi Peoples Hosp, Dept Orthoped, Linzhi, Peoples R China.
   [Chen, Yirong; Ren, Gao-hong] Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Div Orthopaed & Traumatol, 1838th North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China.
   [Chen, Yirong; Ren, Gao-hong] Southern Med Univ, Nanfang Hosp, Key Lab Bone & Cartilage Regenerat Med, Guangzhou, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China
RP Ren, GH (通讯作者)，Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Div Orthopaed & Traumatol, 1838th North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China.
EM doctor020@163.com
RI ; Zeng, CanJun/AHC-5294-2022; Chen, Yirong/T-8449-2019
OI Runguang, Li/0000-0002-4703-7180; 
FU Clinical Research Program of Nanfang Hospital, Southern Medical
   University [2020CR008, 2017KJB-GK-001]; Natural Science Foundation of
   Guangdong Province [2018A030313640, 2019A1515012176]
FX This work was supported by the Clinical Research Program of Nanfang
   Hospital, Southern Medical University (2020CR008); the Shanghai Wang
   Zhengguo Trauma Medical Development Foundation (2017KJB-GK-001); and the
   Natural Science Foundation of Guangdong Province (2018A030313640,
   2019A1515012176).
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NR 34
TC 8
Z9 8
U1 2
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD MAY
PY 2021
VL 49
IS 5
AR 03000605211017618
DI 10.1177/03000605211017618
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA UW6ST
UT WOS:000700283700001
PM 34044634
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Eser, C
   Ceylan, OIK
   Gencel, E
   Tabakan, I
   Kokacya, O
   Yavuz, M
AF Eser, Cengiz
   Ceylan, Ozgun Ilke Karagoz
   Gencel, Eyuphan
   Tabakan, Ibrahim
   Kokacya, Omer
   Yavuz, Metin
TI Reconstruction of Achilles region defects: A single-centre experience
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
DE Achilles; flap; graft; reconstruction; tendon
ID SOFT-TISSUE DEFECTS; PERFORATOR FLAPS; MICROSURGICAL RECONSTRUCTION;
   STAGE RECONSTRUCTION; TENDON DEFECTS; SKIN; KEYSTONE; LEG;
   SUPERMICROSURGERY; ANGIOGRAPHY
AB Background Reconstruction of Achilles tendon and the overlying tissue defects is a challenging undertaking. The spectrum of available repair methods range from secondary healing to the use of free flaps. The aim of this study was to discuss reconstruction options and to help the surgeon to select reliable approach to achieve favourable outcomes. Method In this study, we retrospectively evaluated 14 patients who underwent reconstruction of Achilles region defect between 2016 and 2019 at a single centre. Results Reconstructions were performed with secondary healing (n = 2), negative pressure wound therapy and skin grafting (n = 2), free flaps (n = 6) and local and distant flaps (n = 4). Satisfactory aesthetic and functional outcomes were achieved in all patients. One patient developed partial skin graft loss. Marginal necrosis occurred in one of the local flaps. Wound dehiscence and flap retraction occurred in one of the free (superficial circumflex iliac artery perforator) flaps. One patient undergoing reconstruction with ulnar artery perforator flap developed intraoperative atrial fibrillation; the operation was terminated and reconstruction completed with skin grafting. Conclusion Orthoplastic reconstruction should be kept in mind for Achilles tendon defects. The use of special digital imaging techniques facilitates flap surgery and helps minimise the risk of flap complications. Conventional approaches are suitable for shallow small skin lesions. Local flaps are good options for deeper skin defects owing to superior aesthetic outcomes. Super-thin free flaps offer a distinct advantage in skillful hands. The use of multi-content free chimeric flaps for reconstruction of complex defects facilitates better anatomical repair. Cross leg or flow-through flaps may be considered in patients with compromised distal circulation. Selection of the most reliable approach for Achilles reconstruction is a key imperative to achieve favourable outcomes.
C1 [Eser, Cengiz; Ceylan, Ozgun Ilke Karagoz; Gencel, Eyuphan; Tabakan, Ibrahim; Kokacya, Omer; Yavuz, Metin] Cukurova Univ, Dept Plast Reconstruct & Aesthet Surg, Fac Med, TR-01030 Adana, Turkey.
C3 Cukurova University
RP Kokacya, O (通讯作者)，Cukurova Univ, Dept Plast Reconstruct & Aesthet Surg, Fac Med, TR-01030 Adana, Turkey.
EM kokacya@yahoo.com
RI eser, cengiz/E-8482-2018; /E-9525-2018; /E-7681-2018; Kokaçya,
   Ömer/T-2210-2018
OI Kokaçya, Ömer/0000-0002-1650-5957
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NR 40
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD DEC
PY 2021
VL 75
IS 12
AR e14908
DI 10.1111/ijcp.14908
EA SEP 2021
PG 9
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA XW2FF
UT WOS:000700740200001
PM 34547158
DA 2026-07-24
ER
PT J
AU Ezanno, AC
   Fougerousse, AC
   Guillem, P
AF Ezanno, Anne-Cecile
   Fougerousse, Anne-Claire
   Guillem, Philippe
CA GEM Resoverneuil
TI The role of negative-pressure wound therapy in the management of
   axillary hidradenitis suppurativa
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE axillary; hidradenitis suppurativa; negative-pressure wound therapy;
   wide surgical excision
ID VACUUM-ASSISTED CLOSURE; ARTERY PERFORATOR FLAP; THICKNESS SKIN-GRAFTS;
   SURGICAL-TREATMENT; EXCISION; EXPERIENCE; DRESSINGS; SMOKING
C1 [Ezanno, Anne-Cecile] Begin Mil Hosp, Dept Gastrointestinal & Endocrine Surg, 69 Ave Paris, F-94160 St Mande, France.
   [Fougerousse, Anne-Claire] Begin Mil Hosp, Dept Dermatol, St Mande, France.
   [Guillem, Philippe] Clin Val dOuest, Dept Surg, Ecully, France.
RP Ezanno, AC (通讯作者)，Begin Mil Hosp, Dept Gastrointestinal & Endocrine Surg, 69 Ave Paris, F-94160 St Mande, France.
EM ezanno.annececile@gmail.com
RI ; Guillem, Philippe/AAG-2857-2020; Fougerousse,
   Anne-Claire/AAQ-3902-2020
OI ezanno, anne-cecile/0000-0003-0270-5090; 
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NR 49
TC 13
Z9 15
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2022
VL 19
IS 4
BP 802
EP 810
DI 10.1111/iwj.13678
EA SEP 2021
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 0N6FB
UT WOS:000701238900001
PM 34590422
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wikkeling, M
   Mans, J
   Styche, T
AF Wikkeling, Marald
   Mans, Judith
   Styche, Timothy
TI Single use negative pressure wound therapy in vascular patients:
   clinical and economic outcomes
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE dehiscence; femoral endarterectomy; healthcare; negative pressure; NPWT;
   outcomes; prevention; outcomes; vascular; postoperative; single use;
   surgery; surgical site complication; surgical site infection; sNPWT;
   vascular; wound; wound care; wound healing
ID SURGICAL SITE INFECTION; SURGERY; PREVENTION; SYSTEM
AB Objective: Surgical site complications (SSCs) such as dehiscence and infection are a common issue within vascular surgeries and are a key concern to payers and clinicians. It is estimated that occurrence of complications in vascular surgery can increment length of stay by 9.72 days and costs by 3776 pound per episode. The objective of this research was to determine the clinical and economic impact of the prophylactic use of single use negative pressure wound therapy (sNWPT) in postoperative femoral endarterectomy incisions within a single centre in the Netherlands.
   Method: Data were extracted retrospectively from the medical notes of patients consecutively treated for femoral endarterectomy between January 2013 and December 2019 in a single centre in the Netherlands. Since August 2016, patients were treated with the sNPWT device and their data were compared with that of patients treated before the introduction of the device. Data were extracted on SSCs and associated healthcare resource use, with comparisons made between the two patient groups.
   Results: The study included a cohort of 108 patients. Data of patients treated by standard care (n=64) showed 32 (50%) patients developed complications. This reduced significantly in patients treated with the sNPWT device (n=44) of whom eight (18.2%) developed a postoperative complication (p=0.0011). Average postoperative costs per patient were _3119 for those in the standard care group and _2630 where the sNPWT device was used.
   Conclusion: sNPWT provided clinical and economic benefits over standard care in the treatment of femoral endarterectomy patients, significantly reducing rate of complication and their associated costs. Declaration of interest: TS is an employee of Smith+Nephew.
C1 [Wikkeling, Marald; Mans, Judith] Nij Smellinghe Ziekenhuis, Postbus 20200, NL-9200 DA Drachten, Netherlands.
   [Styche, Timothy] Smith Nephew, 101 Hessle Rd, Kingston Upon Hull, N Humberside, England.
C3 Smith & Nephew
RP Wikkeling, M (通讯作者)，Nij Smellinghe Ziekenhuis, Postbus 20200, NL-9200 DA Drachten, Netherlands.
EM tim.styche@smith-nephew.com
OI Wikkeling, Marald/0000-0002-0439-3345
CR Allegranzi Benedetta, 2016, Lancet Infect Dis, V16, pe288, DOI 10.1016/S1473-3099(16)30402-9
   [Anonymous], 2016, CONS DOC CLOS SURG I
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NR 16
TC 6
Z9 6
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2021
VL 30
IS 9
BP 705
EP 710
DI 10.12968/jowc.2021.30.9.705
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA UY1FF
UT WOS:000701276500005
PM 34554842
DA 2026-07-24
ER
PT J
AU Cifuentes, MP
AF Pacheco Cifuentes, Marcela
TI Use of collagen and negative pressure wound therapy in a diabetic foot
   ulcer: a case study
SO JOURNAL OF WOUND CARE
LA Spanish
DT Article
DE diabetic foot; ulcer; negative pressure wound therapy; collagen;
   diabetes
AB SINOPSIS: The following case study describes the use of a collagen layer in combination with negative pressure wound therapy in a diabetic foot ulcer, treated in a hospital in Chile. The wound reduced 58% in size in the first 10 weeks of treatment, reaching complete healing in the following 14 weeks. The treatment carried out avoided amputation of the foot of the patient who, at 64 years of age, maintained his independence and quality of life.
C1 [Pacheco Cifuentes, Marcela] Univ Chile, Hosp Clin, Unidad Procedimientos, Ctr Consultas & Procedimientos, Santiago, Chile.
C3 Universidad de Chile
RP Cifuentes, MP (通讯作者)，Univ Chile, Hosp Clin, Unidad Procedimientos, Ctr Consultas & Procedimientos, Santiago, Chile.
EM mpachecoc@hcuch.cl
CR [Anonymous], 2019, Atlas de la Diabetes de la FID
   Seguel G, 2013, REV MED CHILE, V141, P1464, DOI 10.4067/S0034-98872013001100014
NR 2
TC 1
Z9 1
U1 0
U2 10
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2021
VL 30
IS 4
SU 1
BP 19
EP 20
DI 10.12968/jowc.2021.30.LatAm_sup_1.19
PG 2
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA UY2VU
UT WOS:000701387700003
PM 34558975
DA 2026-07-24
ER
PT J
AU Chang, CC
   Tang, WR
   Huang, WL
   Chen, YY
   Yen, YT
   Tseng, YL
AF Chang, Chao-Chun
   Tang, Wen-Ruei
   Huang, Wei-Li
   Chen, Ying-Yuan
   Yen, Yi-Ting
   Tseng, Yau-Lin
TI Algorithmic Approach Using Negative Pressure Wound Therapy Improved
   Survival for Patients with Synchronous Hypopharyngeal and Esophageal
   Cancer Undergoing Pharyngolaryngoesophagectomy with Gastric Tube
   Reconstruction
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Article
ID SQUAMOUS-CELL CARCINOMA; INTRAABDOMINAL ABSCESS; PHARYNGOCUTANEOUS
   FISTULA; PERCUTANEOUS DRAINAGE; PULL-UP; HEAD; NECK; MANAGEMENT; IMPACT;
   SURGERY
AB Background This study retrospectively analyzed the feasibility and surgical outcome of an algorithmic approach using negative pressure wound therapy for patients with synchronous hypopharyngeal and esophageal cancer undergoing pharyngolaryngoesophagectomy with gastric tube reconstruction. Methods Patients undergoing pharyngolaryngoesophagectomy and gastric tube reconstruction for hypopharyngeal cancer between 2011 and 2019 were candidates for this study. Data were collected on patient demographics, comorbidities, performance status, cancer stage, treatment, complication, and survival. Survival analysis was performed using the Kaplan-Meier method. The Cox proportional hazards model was used for prognostic factors. Results The study enrolled 43 patients. Anastomotic leakage was found in 21 of the patients with a conventional surgical drain (61.9%) and in 10 of the 22 patients with negative pressure wound therapy (45.5%) (p = 0.280). Nine patients in the conventional drain group (42.9%) and two patients in the negative pressure wound therapy group (9.1%) had leakage-associated complications (p = 0.011). The incidence of pulmonary complications was higher in the conventional surgical drain group (9 vs 2; p = 0.011). The number of complications requiring surgery was higher in the conventional drain group (7 vs 0; p = 0.004). The overall survival in the negative pressure wound therapy group was better (hazard ratio [HR], 0.33; 95% confidence interval [CI], 0.15-0.76; p = 0.009). Negative pressure wound therapy was independently associated with overall survival (HR, 0.31; 95% CI, 0.13-0.77; p = 0.011). Conclusions Negative pressure wound therapy with an algorithmic approach improved the overall survival for the patients undergoing gastric tube reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal and esophageal cancer by preventing deadly complications secondary to anastomotic leakage
C1 [Chang, Chao-Chun; Tang, Wen-Ruei; Huang, Wei-Li; Chen, Ying-Yuan; Yen, Yi-Ting; Tseng, Yau-Lin] Natl Cheng Kung Univ Hosp, Dept Surg, Div Thorac Surg, Tainan, Taiwan.
   [Chang, Chao-Chun; Yen, Yi-Ting] Natl Cheng Kung Univ Hosp, Dept Surg, Div Trauma & Acute Care Surg, Tainan, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University Hospital;
   National Cheng Kung University; National Cheng Kung University Hospital
RP Yen, YT (通讯作者)，Natl Cheng Kung Univ Hosp, Dept Surg, Div Thorac Surg, Tainan, Taiwan.; Yen, YT (通讯作者)，Natl Cheng Kung Univ Hosp, Dept Surg, Div Trauma & Acute Care Surg, Tainan, Taiwan.
EM b85401067@gmail.com
RI Yen, Yi-Ting/AAQ-1691-2020
OI Tang, Wen-Ruei/0000-0003-4006-5506
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NR 39
TC 3
Z9 3
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1068-9265
EI 1534-4681
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD DEC
PY 2021
VL 28
IS 13
BP 8996
EP 9007
DI 10.1245/s10434-021-10365-8
EA SEP 2021
PG 12
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA WX4LM
UT WOS:000701661100001
PM 34585295
DA 2026-07-24
ER
PT J
AU Doman, DM
   Young, AM
   Buller, LT
   Deckard, ER
   Meneghini, RM
AF Doman, David M.
   Young, Allison M.
   Buller, Leonard T.
   Deckard, Evan R.
   Meneghini, R. Michael
TI Comparison of Surgical Site Complications With Negative Pressure Wound
   Therapy vs Silver Impregnated Dressing in High-Risk Total Knee
   Arthroplasty Patients: A Matched Cohort Study
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE closed incision negative pressure would therapy; surgical site
   infection; wound healing; knee replacement; prevention
ID PRIMARY TOTAL HIP; CLOSED INCISION MANAGEMENT; VACUUM-ASSISTED CLOSURE;
   REVISION HIP; INFECTION; PREVENTION; DRAINAGE; OUTCOMES; SURGERY;
   READMISSION
AB Background: Closed incision negative pressure wound therapy (ciNPWT) may reduce surgical site complications following total joint arthroplasty. Although unlikely necessary for all patients, the criteria for utilizing ciNPWT in primary total knee arthroplasty (TKA) remain poorly defined. This study's purpose was to compare the incidence of incisional wound complications, non-incisional complications (ie, dressing reactions), reoperations, and periprosthetic joint infections (PJIs) among a group of high-risk primary TKA patients treated with ciNPWT vs an occlusive silver impregnated dressing.
   Methods: One hundred thirty high-risk primary TKA patients treated with ciNPWT were 1:1 propensity matched and compared to a historical control group treated with an occlusive silver impregnated dressing. High-risk criteria included the following: active tobacco use, diabetes mellitus, body mass index >35 kg/m(2), autoimmune disease, chronic kidney disease, Staphylococcus aureus nasal colonization, and non-aspirin anticoagulation.
   Results: Age, gender, and risk factor profile were comparable between cohorts. The ciNPWT cohort had significantly fewer incisional wound complications (6.9% vs 16.2%; P = .031) and significantly more non-incisional complications (16.9% vs 1.5%; P < .001). No dressing reactions required clinical intervention. There were no differences in reoperations or periprosthetic joint infections (P = 1.000). In multivariate analysis, occlusive silver impregnated dressings (odds ratio 2.9, 95% confidence interval 1.3-6.8, P = .012) and non-aspirin anticoagulation (odds ratio 2.5, 95% confidence interval 1.1-5.6, P = .028) were associated with the development of incisional wound complications.
   Conclusion: Among high-risk patients undergoing primary TKA, ciNPWT decreased incisional wound complications when compared to occlusive silver impregnated dressings, particularly among those receiving non-aspirin anticoagulation. Although an increase in dressing reactions was observed, the clinical impact was minimal. (C) 2021 Elsevier Inc. All rights reserved.
C1 [Doman, David M.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, Ft Gordon, GA USA.
   [Young, Allison M.] Indiana Univ Sch Med, Indianapolis, IN 46202 USA.
   [Buller, Leonard T.; Deckard, Evan R.; Meneghini, R. Michael] Indiana Univ Sch Med, Dept Orthopaed Surg, Indianapolis, IN 46202 USA.
C3 United States Department of Defense; United States Army; Indiana
   University System; Indiana University Bloomington; Indiana University
   System; Indiana University Bloomington
RP Meneghini, RM (通讯作者)，Indiana Univ Sch Med, Indiana Univ Hlth Hip & Knee Ctr, Dept Orthopaed Surg, 13100 East 136th St,Suite 2000, Fishers, IN 46037 USA.
OI Young, Allison/0000-0001-7004-666X
FU Indiana University Health-Indiana School of Medicine Strategic Research
   Initiative
FX The project described was supported by the Indiana University
   Health-Indiana School of Medicine Strategic Research Initiative.
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NR 55
TC 22
Z9 22
U1 0
U2 5
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD OCT
PY 2021
VL 36
IS 10
BP 3437
EP 3442
DI 10.1016/j.arth.2021.05.030
EA JAN 2021
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA UY8OT
UT WOS:000701777400018
PM 34140207
DA 2026-07-24
ER
PT J
AU Kim, PJ
   Lookess, S
   Bongards, C
   Griffin, LP
   Gabriel, A
AF Kim, Paul J.
   Lookess, Siobhan
   Bongards, Christine
   Griffin, Leah Passmore
   Gabriel, Allen
TI Economic model to estimate cost of negative pressure wound therapy with
   instillation vs control therapies for hospitalised patients in the
   United States, Germany, and United Kingdom
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE cost-savings; debridement; infection; wound; wound closure techniques;
   wound healing
ID ANTISEPTIC SOLUTION; SALINE; DEBRIDEMENT; STANDARD; IMPACT
AB An economic model was developed to estimate the cost of negative pressure wound therapy with instillation and dwelling of a topical wound solution vs control therapies. Economic model inputs were means derived from the results of a recently published systematic review and meta-analysis of 13 comparative studies of negative pressure wound therapy with instillation. Means across studies comprising complex acute and chronic wounds for negative pressure wound therapy-instillation vs control (negative pressure wound therapy without instillation, gauze dressings, or gentamicin polymethylmethacrylate beads) groups were 1.77 vs 2.69 operating room visits (P = .008) and 9.88 vs 21.80 therapy days (P = .02), respectively. These inputs plus hospital cost data were used to model costs for the United States, Germany, and the United Kingdom. For the United States, Germany, and United Kingdom, respectively, economic model estimates of total potential per patient savings were $33 338, euro8467, and 5626 pound for negative pressure wound therapy-instillation group vs control, based on assumed number of OR visits during therapy, cost of therapy system, and length of therapy. Model results showed an overall potential cost-savings with negative pressure wound therapy-instillation vs control, based on fewer OR visits and shorter therapy duration as reported in the published systematic review and meta-analysis.
C1 [Kim, Paul J.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 1801 Inwood Rd, Dallas, TX 75390 USA.
   [Lookess, Siobhan; Bongards, Christine; Griffin, Leah Passmore] 3M, San Antonio, TX USA.
   [Gabriel, Allen] Loma Linda Univ, Med Ctr, Dept Plast Surg, Loma Linda, CA USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; 3M; Loma Linda University
RP Kim, PJ (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 1801 Inwood Rd, Dallas, TX 75390 USA.
EM paul.kim@utsouthwestern.edu
RI ; Gabriel, Allen/AFK-3548-2022
OI , Paul/0000-0002-6186-6890; 
CR Ali Mazen, 2020, Wounds, V32, pE110
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NR 35
TC 12
Z9 13
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2022
VL 19
IS 4
BP 888
EP 894
DI 10.1111/iwj.13689
EA SEP 2021
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 0N6FB
UT WOS:000702161800001
PM 34582113
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Carney, BC
   Moffatt, LT
   Travis, TE
   Nisar, S
   Keyloun, JW
   Prindeze, NJ
   Oliver, MA
   Kirkpatrick, LD
   Shupp, JW
AF Carney, Bonnie C.
   Moffatt, Lauren T.
   Travis, Taryn E.
   Nisar, Saira
   Keyloun, John W.
   Prindeze, Nicholas J.
   Oliver, Mary A.
   Kirkpatrick, Liam D.
   Shupp, Jeffrey W.
TI A Pilot Study of Negative Pressure Therapy with Autologous Skin Cell
   Suspensions in a Porcine Model
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Autologous skin cell suspension (ASCS); RECELL System; Negative pressure
   wound therapy (NPWT); Meshed split thickness skin grafting; Burn wounds,
   Duroc pig
ID BURN DEPTH; WOUND THERAPY; PIG; INJURY; MANAGEMENT; GRAFTS; TRIAL;
   SCARS; TIME
AB Background: Negative pressure wound therapy (NPWT) is an option for securing meshed split thickness skin grafts (mSTSGs) after burn excision to optimize skin graft adherence. Recently, the use of autologous skin cell suspension (ASCS) has been approved for use in the treatment of burn injuries in conjunction with mSTSGs.To date, limited data exists regarding the impact of NPWT on healing outcomes when the cellular suspension is utilized. It was hypothesized that NPWT would not negatively impact wound healing of ASCS+mSTSG.
   Materials and Methods: A burn, excision, mSTSG, ASCS +/- NPWT model was used. Two Duroc pigs were utilized in this experiment, each with 2 sets of paired burns. Four wounds received mSTSG+ASCS+NPWT through post-operative day 3, and 4 wounds received mSTSG +ACSC+ traditional ASCS dressings. Cellular viability was characterized prior to spraying. Percent re-epithelialization, graft-adherence, pigmentation, elasticity, and blood perfusion and blood vessel density were assessed at multiple time points through 2 weeks.
   Results: All wounds healed within 14 days with minimal scar pathology and no significant differences in percent re-epithelialization between NPWT, and non-NPWT wounds were ob-served. Additionally, no differences were detected for pigmentation, perfusion, or blood vessel density. NPWT treated wounds had less graft loss and improved elasticity, with elasticity being statistically different.
   Conclusions: These data suggest the positive attributes of the cellular suspension delivered are retained following the application of negative pressure. Re-epithelialization, revascularization, and repigmentation are not adversely impacted. The use of NPWT may be considered as an option when using ASCS with mSTSGs for the treatment of full-thickness burns. (C) 2021 The Authors. Published by Elsevier Inc.
C1 [Carney, Bonnie C.; Moffatt, Lauren T.; Shupp, Jeffrey W.] Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, Washington, DC 20007 USA.
   [Carney, Bonnie C.; Moffatt, Lauren T.; Travis, Taryn E.; Nisar, Saira; Keyloun, John W.; Prindeze, Nicholas J.; Oliver, Mary A.; Kirkpatrick, Liam D.; Shupp, Jeffrey W.] MedStar Hlth Res Inst, FirefightersBurn & Surg Res Lab, Washington, DC USA.
   [Travis, Taryn E.; Shupp, Jeffrey W.] MedStar Washington Hosp Ctr, Burn Ctr, Dept Surg, Washington, DC USA.
   [Keyloun, John W.; Prindeze, Nicholas J.] MedStar Washington Hosp Ctr, Dept Surg, Washington, DC USA.
   [Keyloun, John W.; Prindeze, Nicholas J.] MedStar Georgetown Univ Hosp, Washington, DC USA.
   [Carney, Bonnie C.; Moffatt, Lauren T.; Travis, Taryn E.; Shupp, Jeffrey W.] Georgetown Univ, Dept Surg, Sch Med, Washington, DC USA.
C3 Georgetown University; MedStar Health Research Institute; MedStar
   Washington Hospital Center; MedStar Washington Hospital Center;
   Georgetown University; Georgetown University
RP Shupp, JW (通讯作者)，Bum Ctr, 110 Irving St NW,Suite 3B-55, Washington, DC 20010 USA.
EM jeffrey.w.shupp@medstar.net
RI Travis, Taryn/AAK-8527-2021; Shupp, Jeffrey/AAW-3481-2021
OI Kirkpatrick, Liam/0000-0002-2744-9102
FU AVITA Medical
FX This work was funded by AVITA Medical. The NWPT devices were obtained as
   a donation from KCI. Dr. Shupp is a consultant for AVITA Medical.
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NR 43
TC 13
Z9 13
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD NOV
PY 2021
VL 267
BP 182
EP 196
DI 10.1016/j.jss.2021.05.010
EA JUN 2021
PG 15
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WA1XB
UT WOS:000702685500022
PM 34153561
OA hybrid
DA 2026-07-24
ER
PT J
AU Cikirikcioglu, M
   Ponchant, K
   Murith, N
   Meyer, P
   Yilmaz, N
   Huber, C
AF Cikirikcioglu, Mustafa
   Ponchant, Kevin
   Murith, Nicolas
   Meyer, Philippe
   Yilmaz, Nurcan
   Huber, Christoph
TI Treatment of HeartMate III-LVAD driveline infection by negative pressure
   wound therapy: Result of our case series
SO INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Device-related infection; left ventricular assist devices; driveline
   infections; heart failure; negative pressure wound therapy; HeartMate
   III
ID ASSIST; MANAGEMENT
AB Driveline infection is one of the most frequent complications following left ventricular assist device (LVAD) treatment and there is no consensus for its management. The standard approach to treat foreign-body infection is complete device ablation, which is not always feasible and therefore not an elected method for LVAD driveline infections. Here we share the results from a series of cases successfully treated for driveline infection by negative pressure wound therapy (NPWT) therapy. Between 2016 and 2020, five male patients were hospitalized in our unit with a driveline infection of HeartMate III-LVAD(R). Ultrasonography and/or thoraco-abdominal CT confirmed the diagnosis, infection localization, and abscess formation. Following an antibiotic treatment, an urgent surgical abscess drainage and debridement of the infected tissues were performed. At the end of the procedure, NPWT was applied. NPWT re-dressing and debridement of wound was performed every 3-4 days. The wound was closed surgically after obtaining negative culture results and good healing. The patients were discharged in good condition, without signs of infection. Two patients underwent successful heart transplantation after 1 and 13 months. Other patients did not show any residual or recurrent infection during the follow-up within 25 months. Driveline infection following LVAD implantation is a significant complication and a challenging in terms of management for both; the surgical team and the patient. These results from our case series report a successful and less invasive approach by using NPWT for the treatment of LVAD driveline infections.
C1 [Cikirikcioglu, Mustafa; Ponchant, Kevin; Murith, Nicolas; Yilmaz, Nurcan; Huber, Christoph] Univ Hosp, Div Cardiovasc Surg, Dept Surg, Geneva, Switzerland.
   [Cikirikcioglu, Mustafa; Ponchant, Kevin; Murith, Nicolas; Meyer, Philippe; Yilmaz, Nurcan; Huber, Christoph] Fac Med, Geneva, Switzerland.
   [Meyer, Philippe] Univ Hosp, Div Cardiol, Dept Internal Med, Geneva, Switzerland.
C3 University of Geneva; University of Geneva; University of Geneva
RP Cikirikcioglu, M (通讯作者)，Univ Hosp Geneva, Dept Surg, Div Cardiovasc Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva, Switzerland.
EM mustafa.cikirikcioglu@hcuge.ch
RI Meyer, Philippe/HHC-0770-2022; Murith, Nicolas/IUN-4347-2023; Huber,
   Christoph/G-1141-2014; Yılmaz, Nurcan/KQU-5783-2024
OI Meyer, Philippe/0000-0002-2430-8953; Murith,
   Nicolas/0000-0002-7157-3880; Huber, Christoph/0000-0001-9048-849X; 
CR Akhter SA, 2015, ANN THORAC SURG, V100, P884, DOI 10.1016/j.athoracsur.2015.03.010
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   Saziye K, 2011, INT WOUND J, V8, P229, DOI 10.1111/j.1742-481X.2011.00773.x
   Sharma V, 2012, ANN THORAC SURG, V94, P1381, DOI 10.1016/j.athoracsur.2012.05.074
   Singh A, 2014, ASAIO J, V60, P613, DOI 10.1097/MAT.0000000000000121
   Vanden Eynden F, 2015, ANN TRANSL MED, V3, DOI 10.3978/j.issn.2305-5839.2015.11.30
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   Zierer A, 2007, ANN THORAC SURG, V84, P515, DOI 10.1016/j.athoracsur.2007.03.085
NR 15
TC 8
Z9 11
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0391-3988
EI 1724-6040
J9 INT J ARTIF ORGANS
JI Int. J. Artif. Organs
PD NOV
PY 2021
VL 44
IS 11
BP 912
EP 916
AR 03913988211047250
DI 10.1177/03913988211047250
EA SEP 2021
PG 5
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA WP1FS
UT WOS:000703086000001
PM 34558333
OA Green Submitted, Green Published
DA 2026-07-24
ER
PT J
AU Niimi, Y
   Nakamoto, K
   Kamei, W
   Osa, N
   Hori, K
   Sakurai, H
AF Niimi, Yosuke
   Nakamoto, Kan
   Kamei, Wataru
   Osa, Nagisa
   Hori, Keijiro
   Sakurai, Hiroyuki
TI "Elephant-trunk" negative pressure wound therapy for fixing artificial
   dermis with basic fibroblast growth factor for critical limb ischemia
SO REGENERATIVE THERAPY
LA English
DT Article
DE Negative pressure wound therapy; NPWT; Critical limb ischemia; CLI;
   Peripheral arterial disease; Collagen-gelatin sponge
ID SUSTAINED-RELEASE; CLINICAL-TRIAL; SCAFFOLD
AB Introduction: The treatment of intractable toe ulcer with critical limb ischemia (CLI) is a challenge because of its poor blood flow and the wound. Here, a novel fixation technique for artificial dermis with negative pressure wound therapy (NPWT) was reported.
   Method: After the amputation of toe, artificial dermis made of collagen-gelatin sponge (CGS) was grafted onto the wound where human recombinant basic fibroblast growth factor (bFGF) was sprayed. The foot was put on adhesive iodine-impregnated drape, the artificial-dermis area was covered with a sponge dressing of which another end reached to the drape, and the vacuum port was applied on the dressing sponge sandwiched with two drapes and connected to an NPWT system. Since the shape of sponge-dressing was similar to that of elephant-trunk, the technique in this study was named an "Elephant-trunk" technique.
   Result: During NPWT period, no complications such as air leakage, skin erosion, ischemic around tissue were confirmed. The artificial dermis was engrafted completely at one week after surgery, and the wound was confirmed to close completely.
   Conclusion: This NPWT technique with bFGF and CGS accelerated the healing of wound treated conservatively with artificial dermis in CLI patients. (C) 2021, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.
C1 [Niimi, Yosuke; Nakamoto, Kan; Kamei, Wataru; Osa, Nagisa; Hori, Keijiro; Sakurai, Hiroyuki] Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan.
C3 Tokyo Women's Medical University
RP Niimi, Y (通讯作者)，Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan.
EM niimi.yosuke@twmu.ac.jp; nakamoto.kan@twmu.ac.jp;
   kamei.wataru@twmu.ac.jp; osa.nagisa@twmu.ac.jp; hori.keijiro@twmu.ac.jp;
   sakurai.hiroyuki@twmu.ac.jp
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NR 23
TC 2
Z9 3
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3204
J9 REGEN THER
JI Regen. Ther.
PD DEC
PY 2021
VL 18
BP 316
EP 320
DI 10.1016/j.reth.2021.08.002
PG 5
WC Cell & Tissue Engineering; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA WA7TW
UT WOS:000703088900040
PM 34522724
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Parrado, RH
   Thomas, CS
   Countryman, D
AF Parrado, Raphael H.
   Thomas, Christopher S.
   Countryman, David
TI Successful Treatment of Inguinal Lymphocele After Angiomyomatous
   Hamartoma Resection During Inguinal Hernia Repair
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE inguinal lymphocele; inguinal hernia repair; angiomatous hamartoma;
   negative pressure wound therapy
ID ASSISTED RADICAL PROSTATECTOMY; GROIN LYMPHATIC COMPLICATIONS; THERAPY;
   NODES
AB Introduction. Lymphocele is a relatively common complication following lymphadenectomy of the inguinal lymph nodes; however, it is less common after open inguinal hernia repair. Postoperative lymphocele is usually caused by unrecognized injury to lymphatic vessels during surgical dissection and commonly requires reoperation to ligate the leaking lymphatics. Angiomyomatous hamaromas are rare lymphatic formations of unknown cause that can be treated with aspiration, scierotherapy, and drain placement, but surgical intervention is often required. This finding is associated with replacement of parenchymal lymph tissue with vascular and smooth muscle cells. Case Report. The authors report the case of a 59-year-old African American male who underwent open inguinal hernia repair and was found to have incidentally an angiomyomatous hamartoma, which was excised but complicated with a postoperative lymphocele. The patient was successfully treated with the aid of negative pressure wound therapy. Conclusions. Negative pressure wound therapy has rarely been used to treat postoperative lymphocele. To the authors' knowledge, this case is the first to document use of negative pressure wound therapy for lymphocele following angiomyomatous hamartoma excision.
C1 [Parrado, Raphael H.; Thomas, Christopher S.; Countryman, David] Med Univ South Carolina, Dept Surg, Div Gen Surg, Charleston, SC 29425 USA.
C3 Medical University of South Carolina
RP Parrado, RH (通讯作者)，96 Jonathon Lucas St,CSB 423-A,MSC 616, Charleston, SC 29425 USA.
EM Parrado@musc.edu
OI Parrado, Raphael/0000-0003-0388-3948
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NR 23
TC 2
Z9 2
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2021
VL 33
IS 7
BP E42
EP E45
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA WC5GQ
UT WOS:000704285500001
PM 34597268
DA 2026-07-24
ER
PT J
AU Hodge, JG
   Pistorio, AL
   Neal, CA
   Dai, HY
   Nelson-Brantley, JG
   Steed, ME
   Korentager, RA
   Zamierowski, DS
   Mellott, AJ
AF Hodge, Jacob G.
   Pistorio, Ashley L.
   Neal, Christopher A.
   Dai, Hongyan
   Nelson-Brantley, Jennifer G.
   Steed, Molly E.
   Korentager, Richard A.
   Zamierowski, David S.
   Mellott, Adam J.
TI Novel insights into negative pressure wound healing from an in situ
   porcine perspective
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE biomedical engineering; foreign body response; genomics; negative
   pressure wound therapy; porcine model; wound healing
ID VACUUM-ASSISTED CLOSURE; THROMBUS COMPONENTS; VAC(R) THERAPY; BACTERIAL
   LOAD; MANAGEMENT; REPAIR; PATHOPHYSIOLOGY; NEUTROPHILS; MIGRATION;
   ADHESION
AB Negative pressure wound therapy (NPWT) is used clinically to promote tissue formation and wound closure. In this study, a porcine wound model was used to further investigate the mechanisms as to how NPWT modulates wound healing via utilization of a form of NPWT called the vacuum-assisted closure. To observe the effect of NPWT more accurately, non-NPWT control wounds containing GranuFoam (TM) dressings, without vacuum exposure, were utilized. In situ histological analysis revealed that NPWT enhanced plasma protein adsorption throughout the GranuFoam (TM), resulting in increased cellular colonization and tissue ingrowth. Gram staining revealed that NPWT decreased bacterial dissemination to adjacent tissue with greater bacterial localization within the GranuFoam (TM). Genomic analysis demonstrated the significant changes in gene expression across a number of genes between wounds treated with non-NPWT and NPWT when compared against baseline tissue. However, minimal differences were noted between non-NPWT and NPWT wounds, including no significant differences in expression of collagen, angiogenic, or key inflammatory genes. Similarly, significant increases in immune cell populations were observed from day 0 to day 9 for both non-NPWT and NPWT wounds, though no differences were noted between non-NPWT and NPWT wounds. Furthermore, histological analysis demonstrated the presence of a foreign body response (FBR), with giant cell formation and encapsulation of GranuFoam (TM) particles. The unique in situ histological evaluation and genomic comparison of non-NPWT and NPWT wounds in this pilot study provided a never-before-shown perspective, offering novel insights into the physiological processes of NPWT and the potential role of a FBR in NPWT clinical outcomes.
C1 [Hodge, Jacob G.] Univ Kansas, Bioengn Grad Program, Lawrence, KS 66160 USA.
   [Pistorio, Ashley L.] Univ Nevada, Dept Plast Surg, Las Vegas, NV USA.
   [Neal, Christopher A.] Univ Kansas, KIDDRC Imaging Core Facil, Med Ctr, Kansas City, KS 66160 USA.
   [Dai, Hongyan] Univ Kansas, Dept Pathol & Lab Med, Med Ctr, Kansas City, KS 66160 USA.
   [Nelson-Brantley, Jennifer G.] Univ Kansas, Dept Anat & Cell Biol, Med Ctr, Kansas City, KS 66160 USA.
   [Steed, Molly E.] Univ Kansas, Dept Pharm Practice, Lawrence, KS USA.
   [Korentager, Richard A.; Zamierowski, David S.; Mellott, Adam J.] Univ Kansas, Dept Plast Surg, Med Ctr, 3051,3901 Rainbow Blvd, Kansas City, KS 66160 USA.
C3 University of Kansas; Nevada System of Higher Education (NSHE);
   University of Nevada Las Vegas; University of Kansas; University of
   Kansas Medical Center; University of Kansas; University of Kansas
   Medical Center; University of Kansas; University of Kansas Medical
   Center; University of Kansas; University of Kansas; University of Kansas
   Medical Center
RP Mellott, AJ (通讯作者)，Univ Kansas, Dept Plast Surg, Med Ctr, 3051,3901 Rainbow Blvd, Kansas City, KS 66160 USA.
EM amellott@kumc.edu
RI Mellott, AJ/HOF-9580-2023; Korentager, Richard/ABE-4955-2021; Pistorio,
   Ashley/AAU-8171-2020
OI Mellott, AJ/0000-0002-7545-3763; Nelson-Brantley, Brantley,
   Jennifer/0000-0003-2343-9721; A Neal, Christopher/0000-0002-9691-2746
FU Zam Research LLC; Department of Plastic Surgery at the University of
   Kansas Medical Center, Kansas City, KS, USA; KIDDRC NIH [U54 HD 090216];
   Kansas Institutional Development Award (IDeA) Network of Biomedical
   Research Excellence (K-INBRE) [P20GM103418]; National Institute of
   General Medical Sciences [P20GM103418] Funding Source: NIH RePORTER
FX The funding was provided by Zam Research LLC and the Department of
   Plastic Surgery at the University of Kansas Medical Center, Kansas City,
   KS, USA. This project was supported by the KIDDRC NIH U54 HD 090216 and
   Kansas Institutional Development Award (IDeA) Network of Biomedical
   Research Excellence (K-INBRE) under grant number P20GM103418.
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NR 61
TC 5
Z9 7
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN
PY 2022
VL 30
IS 1
BP 64
EP 81
DI 10.1111/wrr.12971
EA OCT 2021
PG 18
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA XY4EA
UT WOS:000704434200001
PM 34618990
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Launois, T
   Moor, PL
   Berthier, A
   Merlin, N
   Rieu, F
   Schlotterer, C
   Siege, A
   Fruit, G
   Dugdale, A
   Vandeweerd, JM
AF Launois, Thomas
   Moor, Pierre-Louis
   Berthier, Amelie
   Merlin, Nathalie
   Rieu, Francois
   Schlotterer, Christophe
   Siege, Anthony
   Fruit, Garance
   Dugdale, Alexandra
   Vandeweerd, Jean-Michel
TI Use of Negative Pressure Wound Therapy in the Treatment of Limb Wounds:
   A Case Series of 42 Horses
SO JOURNAL OF EQUINE VETERINARY SCIENCE
LA English
DT Article
DE Negative pressure wound therapy; Wound care; VAC therapy system;
   Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Traumatic limb injuries are common in horses. Negative pressure wound therapy (NPWT) has been proven to promote wound healing in human medicine. It has also been described for the treatment of wounds in horses. In this retrospective study, clinical records of 42 (n = 42) animals were assessed. Categories of wounds, duration of NPWT application, frequency of resetting the NPWT device, technical complications, and tolerance to the procedure were recorded. 42 wounds were classified as bony (n = 15; 36 %), articular (n = 14; 33 %), tenosynovial (n = 9; 21%), muscular (n = 2; 5%) and cutaneous (n = 2; 5 %). NPWT was used to help (1) first intention healing by preoperative (n = 3; 7 %) or postoperative (n = 7; 17%) application, (2) second intention healing (n = 31; 74%), and (3) delayed primary closure (n = 1; 2%). Duration of NPWT application ranged from 2 to 36 days (mean 11.5), with the system staying in place for periods ranging from 1 to 7 days (mean 4.5). In 69% (n = 29) of the cases, healing was considered satisfactory at discharge. 26 % (n = 11) of horses were discharged whilst ideally NPWT should have been continued. 2 animals (n = 2; 5%) were euthanized after surgery due to unrelenting pain. The procedure was well tolerated except in 1 horse who showed signs of discomfort at the first application. This study demonstrated that NPWT with long periods of application can be used successfully to manage various types of limb wounds. (c) 2021 Published by Elsevier Inc.
C1 [Launois, Thomas; Moor, Pierre-Louis; Berthier, Amelie; Merlin, Nathalie; Rieu, Francois; Schlotterer, Christophe; Siege, Anthony] Clin Lys, Dammarie Lez Lys, France.
   [Fruit, Garance; Vandeweerd, Jean-Michel] Univ Namur, Integrated Vet Res Unit IVRU, Namur Res Inst Life Sci NARILIS, Dept Vet Med,Fac Sci, Namur, Belgium.
   [Dugdale, Alexandra] ChesterGates Vet Specialists CVS UK Ltd Units E&F, Gates Lane, Chester, Cheshire, England.
C3 University of Namur
RP Vandeweerd, JM (通讯作者)，Univ Namur, Rue Bruxelles 61, B-5000 Namur, Belgium.
EM jean-michel.vandeweerd@unamur.be
RI Dugdale, Alexandra/JED-9587-2023
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NR 17
TC 7
Z9 8
U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0737-0806
EI 1542-7412
J9 J EQUINE VET SCI
JI J. Equine Vet. Sci.
PD NOV
PY 2021
VL 106
AR 103725
DI 10.1016/j.jevs.2021.103725
EA AUG 2021
PG 4
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA WD4HA
UT WOS:000704902700005
PM 34670699
OA Green Published
DA 2026-07-24
ER
PT J
AU Jiang, X
   Bu, FY
   Xu, Y
   Jing, ZH
   Jiao, GQ
   Li, MQ
   Rong, XS
AF Jiang, Xia
   Bu, Fanyu
   Xu, Yong
   Jing, Zhaohui
   Jiao, Guoqing
   Li, Mingqiu
   Rong, Xiaosong
TI Antibiotic-loaded bone cement combined with vacuum sealing drainage to
   treat deep sternal wound infection following cardiac surgery: the first
   case report
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Antibiotic-loaded bone cement; Vacuum sealing drainage; Deep sternal
   wound infection
ID MEDIAN STERNOTOMY; RISK-FACTORS
AB Background Deep sternal wound infection (DSWI) is a rare but serious complication after median sternotomy, and treatment success depends mainly on surgical experience. Here we first present a case of a patient successfully treated for antibiotic-loaded bone cement (ALBC) combined with vacuum sealing drainage (VSD) of DSWI. Case presentation This case report presented a patient who underwent open heart surgery, and suffered postoperatively from a DSWI associated with enterococcus cloacae. Focus debridement combined with ALBC filling and VSD was conducted in stage I. Appropriate antibiotics were started according to sensitivity to be continued for 2 weeks until the inflammatory markers decreased to normal. One month after the surgery, patient's wound was almost healed and was discharged from hospital with a drainage tube. Two months after the stage I surgery procedure, the major step was removing the previous ALBC, and extensive debridement in stage II. The patient fully recovered without further surgical treatment. Conclusions The results of this case suggest that ALBC combined with VSD may be a viable and safe option for deep sternal wound reconstruction.
C1 [Jiang, Xia; Xu, Yong; Jing, Zhaohui; Jiao, Guoqing; Li, Mingqiu; Rong, Xiaosong] Nanjing Med Univ, Wuxi Affiliated Hosp, Wuxi Peoples Hosp, Dept Cardiovasc Surg, Wuxi 214203, Jiangsu, Peoples R China.
   [Bu, Fanyu] Soochow Univ, Dept Chron Wound, Wuxi Peoples Hosp 9, Wuxi 214062, Jiangsu, Peoples R China.
C3 Jiangnan University; Nanjing Medical University; Soochow University -
   China
RP Li, MQ; Rong, XS (通讯作者)，Nanjing Med Univ, Wuxi Affiliated Hosp, Wuxi Peoples Hosp, Dept Cardiovasc Surg, Wuxi 214203, Jiangsu, Peoples R China.
EM LMQ.2109@163.com; rxswx@163.com
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NR 18
TC 2
Z9 3
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD OCT 10
PY 2021
VL 16
IS 1
AR 292
DI 10.1186/s13019-021-01673-x
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA WE1JT
UT WOS:000705384700005
PM 34629078
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ge, XJ
   Sun, YT
   Lin, J
   Zhou, F
   Yao, G
   Luo, BL
   Su, X
AF Ge, Xiaojing
   Sun, Yute
   Lin, Jing
   Zhou, Fang
   Yao, Gang
   Luo, Binlin
   Su, Xin
TI Diagnostic Key Points and Surgical Management of Necrotizing Fasciitis:
   A Retrospective Study
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE necrotizing fasciitis; soft tissue infection; suppuration; gangrene;
   negative-pressure wound therapy
ID ULTRASONOGRAPHY; CLOSURE
AB Necrotizing fasciitis (NF) is a fatal disease with a high mortality rate that can be easily misdiagnosed. The aim of this study was to improve the diagnostic rate of NF and overall survival. We conducted a single-center, retrospective, noncontrolled study involving 36 patients who were admitted to our department between December 2017 and October 2019, and summarized the diagnostic key points and timing of surgical treatment. All patients were diagnosed at our department and underwent multiple courses of treatment. The records included information regarding underlying diseases, bacterial culture results, laboratory risk indicator for necrotizing fasciitis (LRINEC) score, number of procedures, and type of antibiotics. All 36 cases of NF were cured and showed good patient condition on follow-up; the mean number of surgeries was three, and the mean duration of hospitalization was 37 days (range, 21-83 days). The LRINEC scores of 16 patients were >= 8 points. Seventeen patients with underlying diabetic disease had higher inflammatory index scores than those without diabetes. The LRINEC scores of patients with (n = 17) and without (n = 19) DM were 7.40 +/- 2.99 and 3.80 +/- 2.39, respectively (P < .01). Cases of NF that were treated with early incision and surgical abscess drainage required fewer surgeries and a shorter length of hospitalization. Thus, surgeons should be more aware of NF and aim to make an early and accurate diagnosis using various approaches. Complete surgical debridement plays an essential role in NF treatment, and diabetes mellitus is a significant adverse factor that exacerbates the severity of NF. Negative-pressure techniques are useful in cases involving nonanaerobic infections and cause minimal complications.
C1 [Ge, Xiaojing; Sun, Yute; Lin, Jing; Zhou, Fang; Yao, Gang; Luo, Binlin; Su, Xin] Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China.
C3 Nanjing Medical University
RP Luo, BL; Su, X (通讯作者)，Nanjing Med Univ, Affiliated Hosp 1, Dept Plast & Burn Surg, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM luobin8212192340@sina.com; suxin@jsph.org.cn
OI Su, Xin/0000-0002-2117-9009; Sun, YuTe/0000-0002-2914-445X
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NR 35
TC 5
Z9 6
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2024
VL 23
IS 1
SI SI
BP 153
EP 160
AR 15347346211045282
DI 10.1177/15347346211045282
EA OCT 2021
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LM1U5
UT WOS:000705988900001
PM 34612747
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Jia, ZG
   Liu, L
   Zhang, SQ
   Zhao, XT
   Luo, L
   Tang, YZ
   Shen, B
   Chen, MW
AF Jia, Zeguo
   Liu, Lei
   Zhang, Shiqian
   Zhao, Xiaotong
   Luo, Li
   Tang, Yizhong
   Shen, Bing
   Chen, Mingwei
TI Proteomics changes after negative pressure wound therapy in diabetic
   foot ulcers
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE diabetic foot ulcer; negative-pressure wound therapy; label-free
   quantitative mass spectrometry; differentially expressed proteins;
   cathepsin S; protein S isoform 1; inter alpha-trypsin inhibitor heavy
   chain H4; peroxiredoxin-2
ID CATHEPSIN-S; PROTEIN-S; TRYPSIN INHIBITOR; SKIN; FIBRONECTIN;
   EXPRESSION; TISSUE; ULCERATION; MIGRATION; SURVIVAL
AB Label-free quantitative mass spectrometry was used to analyze the differences in the granulation tissue protein expression profiles of patients with diabetic foot ulcers (DFUs) before and after negative-pressure wound therapy (NPWT) to understand how NPWT promotes the healing of diabetic foot wounds. A total of three patients with DFUs hospitalized for Wagner grade 3 were enrolled. The patients received NPWT for one week. The granulation tissue samples of the patients prior to and following NPWT for one week were collected. The protein expression profiles were analyzed with label-free quantitative mass spectrometry and the differentially expressed proteins (DEPs) in the DFU patients prior to and following NPWT for one week were identified. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were conducted to annotate the DEPs and DEP-associated signaling pathways. Western blotting and ELISA were performed to validate the results. By comparing the differences in the protein profiles of granulation tissue samples prior to and following NPWT for one week, 36 proteins with significant differences were identified (P<0.05); 33 of these proteins were upregulated and three proteins were downregulated. NPWT altered proteins mainly associated with antioxidation and detoxification, the cytoskeleton, regulation of the inflammatory response, complement and coagulation cascades and lipid metabolism. The functional validation of the DEPs demonstrated that the levels of cathepsin S in peripheral blood and granulation tissue were significantly lower than those prior to NPWT (P<0.05), while the levels of protein S isoform 1, inter alpha-trypsin inhibitor heavy chain H4 and peroxiredoxin-2 in peripheral blood and granulation tissue were significantly higher than those prior to NPWT (P<0.05). The present study identified multiple novel proteins altered by NPWT and laid a foundation for further studies investigating the mechanism of action of NPWT.
C1 [Jia, Zeguo; Liu, Lei; Zhang, Shiqian; Zhao, Xiaotong; Luo, Li; Chen, Mingwei] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
   [Tang, Yizhong] Anhui Med Univ, Affiliated Hosp 1, Dept Burns, Hefei 230032, Anhui, Peoples R China.
   [Shen, Bing] Anhui Med Univ, Sch Basic Med Sci, Hefei 230022, Anhui, Peoples R China.
   [Chen, Mingwei] Anhui Univ Chinese Med, Inst Tradit Chinese Med Prevent & Control Diabet, Hefei 230012, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University; Anhui University of Chinese Medicine
RP Chen, MW (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
EM chmwl@163.com
RI CHEN, MINGWEI/KHT-6744-2024
OI , Bing/0000-0001-7263-4748
FU Key Research and Development Program of Anhui Province
   [202004a07020016]; Natural Science Foundation of Anhui Province
   [2108085MH269]
FX This study was supported by grants from the Key Research and Development
   Program of Anhui Province (grant no. 202004a07020016) and the Natural
   Science Foundation of Anhui Province (grant no. 2108085MH269).
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NR 74
TC 12
Z9 17
U1 0
U2 23
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD DEC
PY 2021
VL 24
IS 6
AR 834
DI 10.3892/mmr.2021.12474
PG 15
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA WF3UL
UT WOS:000706233500001
PM 34608502
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Fan, W
   Hou, FS
   Xi, K
   Hao, C
   Lu, XD
   Zhao, B
AF Fan, Wei
   Hou, Fushan
   Xi, Kun
   Hao, Chen
   Lu, Xiangdong
   Zhao, Bin
TI A filled chocolates technique to seal negative-pressure wound therapy
   around external fixation devices: a randomized controlled trial
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Background: In complex injuries, external fixation device represents a challenge to maintain negative-pressure wound therapy (NPWT). In this trial, we compared a combination of bone wax and colostomy paste versus bone wax alone to seal NPWT around external fixation devices.
   Methods: Debridement surgeries of limbs with open fracture and large soft tissue defect need NPWT to be applied around the external fixation devices were randomized into two groups. The seal between external fixation devices and the drape was established using either bone wax first and then reinforced with colostomy paste or bone wax alone. The primary outcome was seal failure within 3 days of debridement. Secondary outcomes included the number of seal failure per debridement surgery and the time spent in repairing the seal within 3 days.
   Results: A total of 56 debridement surgeries were enrolled: 28 to the bone wax/colostomy paste group versus 28 to the bone wax control group. One patient in the control group died 1 day after the first debridement surgery. One patient in the bone wax/colostomy paste group was transferred to other hospitals within 3 days. The final analysis included 27 debridement surgeries in the bone wax/colostomy paste group and 27 debridement surgeries in the control group. The rate of seal failure (defined by loss of negative pressure at anytime within 3 days) was 81.5% (22/27) in the control group versus 11.1% (3/27) in the bone wax/colostomy paste group (p < 0.001; chi(2) test). The bone wax/colostomy paste group also had significantly lower number of seal failures per debridement (median of 0 vs. 2; p = 0.004), and shorter time spent in repairing the seal (median of 0 vs. 18 min; p < 0.001).
   Conclusions: Using bone wax followed by colostomy paste to seal NPWT around external fixation devices reduces seal failure.
C1 [Fan, Wei; Hou, Fushan; Hao, Chen; Lu, Xiangdong; Zhao, Bin] Shanxi Med Univ, Hosp 2, Dept Orthoped, 382 Wuyi Rd, Taiyuan 030001, Shanxi, Peoples R China.
   [Xi, Kun] Soochow Univ, Affiliated Hosp 1, Dept Orthoped, 188 Shizi Rd, Suzhou 215006, Jiangsu, Peoples R China.
C3 Shanxi Medical University; Soochow University - China
RP Lu, XD (通讯作者)，Shanxi Med Univ, Hosp 2, Dept Orthoped, 382 Wuyi Rd, Taiyuan 030001, Shanxi, Peoples R China.
EM luxiangdd@sohu.com; zzbb3737@163.com
RI Xi, Kun/JMQ-1169-2023
OI Xi, Kun/0000-0002-0458-9866; Hou, Fushan/0000-0002-7546-7890
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bulla A, 2014, J ORTHOP TRAUMA, V28, pE176, DOI 10.1097/BOT.0000000000000013
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NR 12
TC 1
Z9 2
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD OCT 12
PY 2021
VL 16
IS 1
AR 587
DI 10.1186/s13018-021-02747-1
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA WG1AB
UT WOS:000706729800001
PM 34641918
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, WJ
   Gu, W
   Jin, XF
   Wang, J
AF Liu, Weijiao
   Gu, Wei
   Jin, Xiaofeng
   Wang, Jian
TI Effects of Simultaneous versus Staged VAC Placement in the Treatment of
   Deep Neck Multiple-Space Infections at a Tertiary Hospital Over a
   Four-Year Period in China
SO INFECTION AND DRUG RESISTANCE
LA English
DT Article
DE deep neck multiple-space infections; DNMIs; necrotizing fasciitis;
   surgical treatment; negative pressure wound therapy
ID PRESSURE-WOUND-THERAPY; ASSISTED CLOSURE; MANAGEMENT; ABSCESSES
AB Purpose: Surgical drainage is an essential part of treatment for deep neck infections (DNIs) or deep neck multiple-space infections (DNMIs). With the emergence and application of new technologies and new materials, vacuum-assisted closure (VAC) in the treatment of DNMIs has been reported. However, reports on the timing of VAC placement are limited. Herein, we compared simultaneous versus staged VAC placement in the treatment of DNMIs. Patients and Methods: Medical data from 24 patients with DNMIs who had received VAC treatment in the last five years were analyzed. The patients were classified into a simultaneous VAC placement group (11 patients) and a staged VAC placement group (13 patients) according to the timing of VAC placement when incision and drainage were performed. Results: No differences in baseline characteristics were found between the two groups. All patients in the two groups survived and recovered. The hospitalization duration (days), time to wound healing (days), number of debridement procedures, and disease course (days) in the simultaneous VAC placement group and staged VAC placement group were 10 (4-18) and 22 (8-35), 21 (4-39) and 50 (9-86), one (1-2) and two (1-4), and 31.5 (11-49) and 56 (19-98), respectively. The results in the simultaneous VAC placement group were better than those in the staged VAC placement group (P = 0.001, 0.016, 0.045, and 0.016, respectively). The numbers of VAC sponge changes in the simultaneous VAC placement group and staged VAC placement group were two (1-2) and two (1-4), respectively, with no statistically significant difference (P = 0.336). Conclusion: Simultaneous VAC placement during incision and drainage may shorten the wound healing time, hospitalization duration, and disease course and may reduce the number of debridement procedures.
C1 [Liu, Weijiao; Gu, Wei; Jin, Xiaofeng; Wang, Jian] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Otolaryngol Head & Neck Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China.
   [Liu, Weijiao] Capital Med Univ, Beijing Friendship Hosp, Dept Otolaryngol Head & Neck Surg, Pinggu Campus, Beijing, Peoples R China.
   [Wang, Jian] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Capital Medical University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College Hospital; Peking
   Union Medical College
RP Wang, J (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Otolaryngol Head & Neck Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China.
EM wangjianent@126.com
FU Nature Science Foundation of Beijing, China [7192171]
FX This study was funded by the Nature Science Foundation of Beijing, China
   (Grant No. 7192171) .
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NR 29
TC 3
Z9 6
U1 0
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2021
VL 14
BP 4091
EP 4096
DI 10.2147/IDR.S334203
PG 6
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA WH0EX
UT WOS:000707363400002
PM 34675554
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Deborre, C
   Ezissi, A
   Jaenisch, M
   Khoury, M
   Burger, C
   Randau, TM
   Kohlhof, H
AF Deborre, Christoph
   Ezissi, Afoma
   Jaenisch, Max
   Khoury, Mona
   Burger, Christof
   Randau, Thomas Martin
   Kohlhof, Hendrik
TI Use of a Negative-Pressure Wound Dressing to Prevent Surgical Site
   Complications after Revision Knee Arthroplasty-A Randomized Controlled
   Trial
SO APPLIED SCIENCES-BASEL
LA English
DT Article
DE knee; revision; arthroplasty; negative-pressure wound dressing
ID VACUUM-ASSISTED CLOSURE; QUALITY-OF-LIFE; TOTAL HIP; JOINT INFECTION;
   THERAPY; REPLACEMENT; OUTCOMES; SURGERY; RISK; AGE
AB The aim of this study was to determine if a negative pressure wound therapy (NPWT) system can facilitate wound healing and withstand mechanical stress owing to the high range of motion of the knee joint in total knee arthroplasty. The benefits of NPWT include aiding wound granulation and a reduction in wound edema and secretion; our goal is to investigate its benefits in primary wound closure. Within an eight-day duration of treatment, we compared standard wound dressing (gauze and compression) with the disposable NPWT system (PICO)(TM). A total of 79 patients were recruited in a controlled, randomized, prospective, single-institution clinical trial. A total of 40 patients were allocated to the study group and 39 to the control group. In terms of blood loss and infection parameters, there was no significant difference between both groups. In the NPWT group, we determined a significant reduction in wound edema but none in wound secretion. While the NPWT dressings survived the mechanical effects of movement during postoperative physiotherapy, conventional compressive dressings were often renewed. Even though the risk factors that could lead to delayed wound healing were reduced in the test group, we could not identify any significant difference pertaining to delayed wound healing that required surgical treatment.
C1 [Deborre, Christoph; Ezissi, Afoma; Jaenisch, Max; Khoury, Mona; Burger, Christof; Randau, Thomas Martin; Kohlhof, Hendrik] Univ Hosp Bonn, Dept Orthopaed & Traumatol, Venusberg Campus 1, D-53127 Bonn, Germany.
C3 University of Bonn
RP Jaenisch, M (通讯作者)，Univ Hosp Bonn, Dept Orthopaed & Traumatol, Venusberg Campus 1, D-53127 Bonn, Germany.
EM chrisdeborre@gmx.de; aezissi@googlemail.com; max.jaenisch@ukbonn.de;
   mona.khoury@ukb.uni-bonn.de; christof.burger@ukb.uni-bonn.de;
   thomassandau@ukb.uni-bonn.de; hendrik.kohlhof@ukb.uni-bonn.de
RI Randau, Thomas/AEP-9749-2022; Kohlhof, Hendrik/IYS-6108-2023; Jaenisch,
   Max/KXR-7055-2024
OI Randau, Thomas/0000-0002-5224-9639; Jaenisch, Max/0000-0001-5998-0224
FU Smith and Nephew, London, Great Britain [N-014.0099]
FX E.A. received a personal grant from Smith and Nephew, London, Great
   Britain (N-014.0099).
CR [Anonymous], Surgical site infections: prevention and treatment
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NR 36
TC 1
Z9 1
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD OCT
PY 2021
VL 11
IS 19
AR 9102
DI 10.3390/app11199102
PG 11
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA WH3HC
UT WOS:000707572400001
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhang, CM
   Wang, Q
   Wang, ZM
   Huang, Q
   Zhang, CC
   Duan, N
   Lin, H
   Ma, T
   Zhang, K
   Xue, HZ
   Li, Z
AF Zhang, Congming
   Wang, Qian
   Wang, Zhimeng
   Huang, Qiang
   Zhang, Chenchen
   Duan, Ning
   Lin, Hua
   Ma, Teng
   Zhang, Kun
   Xue, Hanzhong
   Li, Zhong
TI Modified negative-pressure wound therapy for linear blister formation
   prevention around foam dressings: technical note and case series
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Linear blister prevention; Open fracture; Surgical technique;
   Negative-pressure wound therapy
ID VACUUM SEALING DRAINAGE; ASSISTED CLOSURE; TIBIAL FRACTURES; LOWER-LIMB;
   MANAGEMENT; INFECTION
AB Background Linear blisters (LBs) often occur around dressings when negative-pressure wound therapy (NPWT) is used to cover open wounds. Tension blisters may increase the wound infection incidence rate, delay the start of operation, and prolong the duration of hospital stay. Currently, there are no established methods for the prevention of LB formation around dressings, which remains to be a major concern in clinical applications. Therefore, we developed a novel, simple, reproducible, and convenient method for preventing LB formation around NPWT dressings. Method Fifty-three cases of Gustilo type II and III open fractures under NPWT were considered. NPWT was used on every wound after debridement. All patients were divided into a conventional group (27 cases, 33 wounds) and a novel group (26 cases, 27 wounds) based on the difference in the NPWT dressing appearance. A healthy volunteer with intact skin was also included to perform the detailed process of NPWT. LBs occurring on intact skin around the dressings were observed and recorded when the dressing was removed 3 days after the operation. The occurrence of LB formation and wound infection was considered as categorical data and compared between the two groups using a chi-square test. The duration of hospital stay was considered as numerical data and compared between the two groups using two independent t tests. Results The percentage of occurrence of LB formation around dressings in the conventional group was 27.3%, whereas it was merely 3.7% in the novel group (P = 0.037). The infection incidence rate in the conventional group was 30.3%, whereas that in the novel group was 25.9%; however, no statistical difference was observed between the two groups (P = 0.708). The average duration of hospital stay in the conventional group was 14.39 +/- 4.55 days, whereas that in the novel group was 11.04 +/- 3.47 days (P = 0.003). Conclusion Thus, changing the NPWT dressing appearance can prevent LB formation around dressings, providing an effective method to improve NPWT application. Modified NPWT dressings also shorten the duration of hospital stay, but do not significantly decrease the incidence of wound infection.
C1 [Zhang, Congming; Wang, Qian; Wang, Zhimeng; Huang, Qiang; Zhang, Chenchen; Duan, Ning; Lin, Hua; Ma, Teng; Zhang, Kun; Xue, Hanzhong; Li, Zhong] Xi An Jiao Tong Univ, Coll Med, Hong Hui Hosp, Dept Orthopaed & Traumatol, 555 Youyi Rd, Xian 710054, Peoples R China.
C3 Xi'an Jiaotong University
RP Xue, HZ; Li, Z (通讯作者)，Xi An Jiao Tong Univ, Coll Med, Hong Hui Hosp, Dept Orthopaed & Traumatol, 555 Youyi Rd, Xian 710054, Peoples R China.
EM 13759963709@163.com; lizhong0607@126.com
RI Zhang, Chenchen/GPW-7947-2022; Zhang, Kun/S-5005-2019
FU Project of Science and Technology Department of Shaanxi Province
   [2016JM8151, 2016SF-340]
FX This study was financially supported by the Project of Science and
   Technology Department of Shaanxi Province (2016JM8151, 2016SF-340).
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NR 24
TC 8
Z9 8
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD OCT 15
PY 2021
VL 16
IS 1
AR 602
DI 10.1186/s13018-021-02759-x
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA WH3KC
UT WOS:000707580200003
PM 34654453
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sabapathy, SR
   del Piñal, F
   Boyer, MI
   Lee, DC
   Sebastin, SJ
   Venkatramani, H
AF Sabapathy, S. Raja
   del Pinal, Francisco
   Boyer, Martin I.
   Lee, Dong Chul
   Sebastin, Sandeep Jacob
   Venkatramani, Hari
TI Management of a mutilated hand: the current trends
SO JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
LA English
DT Review
DE Mutilated hand; mangled extremity; microsurgical hand reconstruction;
   limb salvage
ID UPPER EXTREMITY; MICROSURGICAL RECONSTRUCTION; OPEN FRACTURES; INJURIES;
   DEBRIDEMENT; FLAP; CLASSIFICATION; REEVALUATION; GUIDELINES; OUTCOMES
AB Mutilated upper limbs suffer loss of substance of various tissues with loss of prehension. The most important factor in salvage of a mutilated hand is involvement of a senior surgeon at the time of initial assessment and debridement. A regional block given on arrival helps through assessment and investigations in a pain-free state. Infection still remains the important negative determinant to outcome and is prevented by emergent radical debridement and early soft tissue cover. Radical debridement and secure skeletal stabilization must be achieved on day one in all situations. Dermal substitutes and negative pressure wound therapy are increasingly used but have not substituted regular soft tissue cover techniques. Ability to perform secondary procedures and the increased use of the reconstructed hand with time keeps reconstruction a better option than prosthesis fitting. Toe transfers and free functioning muscle transfers are the two major secondary procedures that have influenced outcomes.
C1 [Sabapathy, S. Raja; Venkatramani, Hari] Ganga Hosp, Dept Plast Hand & Microsurg & Burns, 313 Mettupalayam Rd, Coimbatore 641043, Tamil Nadu, India.
   [Boyer, Martin I.] Washington Univ, Sch Med, Orthopaed Surg, St Louis, MO USA.
   [Lee, Dong Chul] Gwangmyeong Sungae Gen Hosp, Plast & Reconstruct Surg & Hand Surg, Gyeonggi Do, South Korea.
   [Sebastin, Sandeep Jacob] Natl Univ Hlth Syst, Hand & Reconstruct Microsurg, Singapore, Singapore.
C3 Washington University (WUSTL); National University of Singapore
RP Sabapathy, SR (通讯作者)，Ganga Hosp, Dept Plast Hand & Microsurg & Burns, 313 Mettupalayam Rd, Coimbatore 641043, Tamil Nadu, India.
EM rajahand@gmail.com
RI Sabapathy, S Raja/AAL-5420-2020; /E-7820-2010; /AAD-2455-2019; del
   PIñal, Francisco/IUN-5005-2023
OI Sabapathy, S Raja/0000-0002-0456-8555; 
CR Ali B, 2020, PRS-GLOB OPEN, V8, DOI 10.1097/GOX.0000000000002965
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NR 35
TC 6
Z9 10
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1753-1934
EI 2043-6289
J9 J HAND SURG-EUR VOL
JI J. Hand Surg.-Eur. Vol.
PD JAN
PY 2022
VL 47
IS 1
BP 98
EP 104
AR 17531934211047760
DI 10.1177/17531934211047760
EA OCT 2021
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA XV5CM
UT WOS:000707831600001
PM 34632847
DA 2026-07-24
ER
PT J
AU Phiri, CC
   Valle, C
   Botzheim, J
   Ju, ZJ
   Liu, HH
AF Phiri, Charles C.
   Valle, Cristina
   Botzheim, Janos
   Ju, Zhaojie
   Liu, Honghai
TI Fuzzy rule-based model for outlier detection in a Topical Negative
   Pressure Wound Therapy Device
SO ISA TRANSACTIONS
LA English
DT Article
DE Topical Negative Pressure Wound Therapy; Device; Outlier detection;
   Fuzzy rule-based model; Bacterial Memetic Algorithm
ID MEMBERSHIP FUNCTIONS; PARAMETERS; ALGORITHM
AB This paper proposes a novel method for offline outlier detection in nonlinear dynamical systems using an input-output dataset of a Topical Negative Pressure Wound Therapy Device, NPWT. The fundamental characteristics of an NPWT describe a chaotic system whose states vary over time and may result in unpredictable and possibly anomalous divergent behavior in the presence of perturbations and other unmodeled system dynamics, despite a quasi-stable controller. Bacterial Memetic Algorithm, BMA, is used to generate fuzzy rule-based models of the input-output dataset. The error definition in the fuzzy rule extraction features a novel application of the Canberra Distance. The optimal number of rules for identifying the outliers, validated against both artificial and real system datasets, is calculated from the sample of inferred fuzzy models. The optimal number of rules is two in both cases based on the maximum average-error-drop. Using three or more rules results in better error performance; however, the algorithm learns the nuances of the outlier patterns instead. Novel methods for creating the outlier list and determining the optimal number of rules for the outlier detection problem are proposed. (C) 2021 ISA. Published by Elsevier Ltd. All rights reserved.
C1 [Phiri, Charles C.; Valle, Cristina] CC Initiat Ltd, Andover, Hants, England.
   [Phiri, Charles C.; Ju, Zhaojie; Liu, Honghai] Univ Portsmouth, Sch Comp, Portsmouth, Hants, England.
   [Valle, Cristina] Tokyo Metropolitan Univ, Tokyo, Japan.
   [Botzheim, Janos] Budapest Univ Technol & Econ, Fac Mech Engn, Dept Mechatron Opt & Mech Engn Informat, Budapest, Hungary.
C3 University of Portsmouth; Tokyo Metropolitan University; Budapest
   University of Technology & Economics
RP Ju, ZJ (通讯作者)，Univ Portsmouth, Sch Comp, Portsmouth, Hants, England.
EM charles.phiri@cc-initiative.com; cristina.valle@cc-initiative.com;
   botzheim@mogi.bme.hu; zhaojie.ju@port.ac.uk; honghai.liu@port.ac.uk
RI ; Botzheim, Janos/B-2763-2014; Ju, Zhaojie/AAA-5872-2019
OI Liu, Honghai/0000-0002-2880-4698; 
FU European Regional Develop-ment Fund; National Natural Science Foundation
   of China [52075530]; Janos Bolyai Research Scholarship of the Hungarian
   Academy of Sciences, Hungary
FX The authors would like to acknowledge the support from the AiBle project
   co-financed by the European Regional Develop-ment Fund and National
   Natural Science Foundation of China (grant No. 52075530) . Janos
   Botzheim was supported by the Janos Bolyai Research Scholarship of the
   Hungarian Academy of Sciences, Hungary.
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NR 53
TC 4
Z9 5
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0019-0578
EI 1879-2022
J9 ISA T
JI ISA Trans.
PD NOV
PY 2021
VL 117
BP 16
EP 27
DI 10.1016/j.isatra.2021.01.046
EA SEP 2021
PG 12
WC Automation & Control Systems; Engineering, Multidisciplinary;
   Instruments & Instrumentation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Automation & Control Systems; Engineering; Instruments & Instrumentation
GA WH9WO
UT WOS:000708020200002
PM 33581890
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Shao, PL
   Liao, JD
   Wu, SC
   Chen, YH
   Wong, TW
AF Shao, Pei-Lin
   Liao, Jiunn-Der
   Wu, Shun-Cheng
   Chen, Yu-Hsing
   Wong, Tak-Wah
TI Microplasma Treatment versus Negative Pressure Therapy for Promoting
   Wound Healing in Diabetic Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE diabetic wound; nonthermal microplasma treatment; negative pressure
   wound therapy; re-epithelialization; transforming growth factor beta
   signaling
ID NITRIC-OXIDE; PLASMA; EXPRESSION; SKIN; EPITHELIALIZATION;
   MYOFIBROBLASTS; STERILIZATION; ANGIOGENESIS; IMPAIRMENTS; MODELS
AB The delayed healing response of diabetic wounds is a major challenge for treatment. Negative pressure wound therapy (NPWT) has been widely used to treat chronic wounds. However, it usually requires a long treatment time and results in directional growth of wound healing skin tissue. We investigated whether nonthermal microplasma (MP) treatment can promote the healing of skin wounds in diabetic mice. Splint excision wounds were created on diabetic mice, and various wound healing parameters were compared among MP treatment, NPWT, and control groups. Quantitative analysis of the re-epithelialization percentage by detecting Ki67 and DSG1 expression in the extending epidermal tongue (EET) of the wound area and the epidermal proliferation index (EPI) was subsequently performed. Both treatments promoted wound healing by enhancing wound closure kinetics and wound bed blood flow; this was confirmed through histological analysis and optical coherence tomography. Both treatments also increased Ki67 and DSG1 expression in the EET of the wound area and the EPI to enhance re-epithelialization. Increased Smad2/3/4 mRNA expression was observed in the epidermis layer of wounds, particularly after MP treatment. The results suggest that the Smad-dependent transforming growth factor beta signaling contributes to the enhancement of re-epithelialization after MP treatment with an appropriate exposure time. Overall, a short-term MP treatment (applied for 30 s twice a day) demonstrated comparable or better efficacy to conventional NPWT (applied for 4 h once a day) in promoting wound healing in diabetic mice. Thus, MP treatment exhibits promise for treating diabetic wounds clinically.
C1 [Shao, Pei-Lin] Asia Univ, Dept Nursing, Taichung 41354, Taiwan.
   [Liao, Jiunn-Der; Chen, Yu-Hsing] Natl Cheng Kung Univ, Engn Mat Biomed Applicat Lab, Dept Mat Sci & Engn, Tainan 70101, Taiwan.
   [Liao, Jiunn-Der] Natl Cheng Kung Univ, Int Ctr Wound Repair & Regenerat, Tainan 70101, Taiwan.
   [Wu, Shun-Cheng] Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr, Kaohsiung 807378, Taiwan.
   [Wong, Tak-Wah] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Dermatol, Coll Med, Tainan 704, Taiwan.
   [Wong, Tak-Wah] Natl Cheng Kung Univ, Ctr Appl Nanomed, Coll Med, Dept Biochem & Mol Biol, Tainan 70101, Taiwan.
C3 Asia University Taiwan; National Cheng Kung University; National Cheng
   Kung University; Kaohsiung Medical University; National Cheng Kung
   University; National Cheng Kung University Hospital; National Cheng Kung
   University
RP Liao, JD (通讯作者)，Natl Cheng Kung Univ, Engn Mat Biomed Applicat Lab, Dept Mat Sci & Engn, Tainan 70101, Taiwan.; Liao, JD (通讯作者)，Natl Cheng Kung Univ, Int Ctr Wound Repair & Regenerat, Tainan 70101, Taiwan.
EM m8951016@gmail.com; dliao@mail.ncku.edu.tw; shunchengwu@gmail.com;
   ny69896032000@hotmail.com; Dr.kentwwong@gmail.com
RI Wu, Shun-Cheng/E-2989-2010
OI Wu, Shun-Cheng/0000-0003-4219-3413; WONG, TAK-WAH/0000-0002-0131-7339
FU Ministry of Science and Technology of Taiwan [MOST
   108-2218-E-006-054-MY3, MOST 103-2622-B-006-010-and]; MOST
   [108-2218-E-006-054-MY3]
FX This research was funded by Ministry of Science and Technology of
   Taiwan, grant numbers: MOST 108-2218-E-006-054-MY3 and MOST
   103-2622-B-006-010-and the APC was funded by MOST
   108-2218-E-006-054-MY3.
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NR 61
TC 17
Z9 17
U1 1
U2 22
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2021
VL 22
IS 19
AR 10266
DI 10.3390/ijms221910266
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WJ9CN
UT WOS:000709334500001
PM 34638608
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Khoo, MJW
   Ooi, ASH
AF Khoo, Mark Junn Wei
   Ooi, Adrian Seng Huan
TI Management of postreconstructive head and neck salivary fistulae: A
   review of current practices
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Salivary fistula; Enterocutaneous fistula; Pharyngocutaneous fistula;
   Orocutaneous fistula; Reconstructive surgery; Negative pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; FREE TISSUE TRANSFER;
   PHARYNGOCUTANEOUS-FISTULA; LARYNGECTOMY DEFECTS; MICROSURGICAL HEAD;
   RECONSTRUCTION; COMPLICATIONS; METAANALYSIS; DESIGN
AB Background: Salivary fistulas are common complications after reconstructive head and neck surgery with significant morbidity. Yet, there are no established guidelines for their management.
   Method: A comprehensive search of PubMed was performed from 01/01/2000 to 06/31/2019 to evaluate all treatment options in postreconstructive head and neck fistulas.
   Results: Nineteen articles with 132 patients were included. Thirty-nine of 132(30%) patients were treated with conventional wound care. All fistulas closed after 51.6 +/- 54.0 days with no refistulations. Thirty-eight of 132(29%) patients were treated with negative pressure wound therapy (NPWT). Thirty-eight of 40(95%) fistula closed after 14.7 +/- 12.0 days with no refistulations. The reduced healing time was statistically significant as compared to patients on conventional wound care (p < 0.001). Fifty-three of 132(40%) patients received surgical management. Fortyfour of 53(83%) patients had complete fistula closure without postoperative complications. A pedicled flap was used in 60% of cases (n = 32).
   Conclusion: Most salivary fistulas close with conservative management. NPWT potentially shortens fistula healing time while it achieves similar closure rates as conventional wound care. In the absence of contraindications, NPWT should be trialed on all salivary fistulas. Surgical management should be reserved for large, chronic, high-risk fistulas or those not responding to a trial of conservative treatment. Secondary reconstruction should be kept as simple as possible. (C) 2021 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Khoo, Mark Junn Wei] Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Ooi, Adrian Seng Huan] Mt Elizabeth Med Ctr, Polaris Plast & Reconstruct Surg, 3 Mt Elizabeth,08-05, Singapore 288510, Singapore.
C3 National University of Singapore; Mount Elizabeth Medical Centre
RP Ooi, ASH (通讯作者)，Mt Elizabeth Med Ctr, Polaris Plast & Reconstruct Surg, 3 Mt Elizabeth,08-05, Singapore 288510, Singapore.
EM adrian.ooi.s.h@singhealth.com.sg
RI Ooi, Adrian/AAJ-8480-2021
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NR 45
TC 25
Z9 31
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD SEP
PY 2021
VL 74
IS 9
BP 2120
EP 2132
DI 10.1016/j.bjps.2020.12.096
EA SEP 2021
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WK5AA
UT WOS:000709736900018
PM 33551359
DA 2026-07-24
ER
PT J
AU Ji, SZ
   Liu, XB
   Huang, J
   Bao, JM
   Chen, ZH
   Han, CM
   Hao, DF
   Hong, JS
   Hu, DH
   Jiang, YF
   Ju, S
   Li, HY
   Li, ZY
   Liang, GP
   Liu, Y
   Luo, GX
   Lv, GZ
   Ran, XW
   Shi, ZM
   Tang, JY
   Wang, AP
   Wang, GY
   Wang, JN
   Wang, X
   Wen, B
   Wu, J
   Xu, HL
   Xu, MJ
   Ye, XF
   Yuan, LX
   Zhang, Y
   Xiao, SC
   Xia, ZF
AF Ji, Shizhao
   Liu, Xiaobin
   Huang, Jie
   Bao, Junmin
   Chen, Zhaohong
   Han, Chunmao
   Hao, Daifeng
   Hong, Jingsong
   Hu, Dahai
   Jiang, Yufeng
   Ju, Shang
   Li, Hongye
   Li, Zongyu
   Liang, Guangping
   Liu, Yan
   Luo, Gaoxing
   Lv, Guozhong
   Ran, Xingwu
   Shi, Zhongmin
   Tang, Juyu
   Wang, Aiping
   Wang, Guangyi
   Wang, Jiangning
   Wang, Xin
   Wen, Bing
   Wu, Jun
   Xu, Hailin
   Xu, Maojin
   Ye, Xiaofei
   Yuan, Liangxi
   Zhang, Yi
   Xiao, Shichu
   Xia, Zhaofan
TI Consensus on the application of negative pressure wound therapy of
   diabetic foot wounds
SO BURNS & TRAUMA
LA English
DT Article
DE Vacuum sealing drainage; Vacuum-assisted closure; Vacuum-assisted
   therapy; Negative pressure wound therapy; Topical negative pressure
   therapy; Suction wound closure therapy; Diabetic foot; Diabetic ulcer;
   Diabetic wound
ID VACUUM-ASSISTED-CLOSURE; ACELLULAR DERMAL MATRIX; SKIN-GRAFTS; TISSUE
   OXYGENATION; COST-EFFECTIVENESS; CLINICAL-EFFICACY; ULCER TREATMENT;
   LIMB SALVAGE; MANAGEMENT; INSTILLATION
AB Because China is becoming an aging society, the incidence of diabetes and diabetic foot have been increasing. Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates. Negative pressure wound therapy (NPWT) is one of the most effective techniques for the treatment of diabetic foot wounds and great progress, both in terms of research and its clinical application, has been made in the last 20 years of its development. However, due to the complex pathogenesis and management of diabetic foot, irregular application of NPWT often leads to complications, such as infection, bleeding and necrosis, that seriously affect its treatment outcomes. In 2020, under the leadership of Burns, Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association, the writing group for 'Consensus on the application of negative pressure wound therapy of diabetic foot wounds' was established with the participation of scholars from the specialized areas of burns, endocrinology, vascular surgery, orthopedics and wound repair. Drawing on evidence-based practice suggested by the latest clinical research, this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot. The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot.
C1 [Ji, Shizhao; Liu, Xiaobin; Huang, Jie; Bao, Junmin; Wang, Guangyi; Xu, Maojin; Ye, Xiaofei; Yuan, Liangxi; Xiao, Shichu; Xia, Zhaofan] Naval Med Univ, Burn Inst PLA, Dept Burns, Affiliated Hosp 1, 168 Changhai Rd, Shanghai 200433, Peoples R China.
   [Chen, Zhaohong] Fujian Med Univ Union Hosp, Fujian Burn Inst, 29 Xinquan Rd, Fuzhou 350001, Peoples R China.
   [Han, Chunmao] Zhejiang Univ, Coll Med, Dept Burns, Affiliated Hosp 2, 88 Jiefang Rd, Hangzhou 310009, Peoples R China.
   [Han, Chunmao] Zhejiang Univ, Coll Med, Wound Care Ctr, Affiliated Hosp 2, 88 Jiefang Rd, Hangzhou 310009, Peoples R China.
   [Hao, Daifeng] Chinese Peoples Liberat Army Gen Hosp, Dept Burns & Plast Surg 3, Med Ctr 4, 51 Fucheng Rd, Beijing 100048, Peoples R China.
   [Hao, Daifeng] Chinese Peoples Liberat Army Gen Hosp, Wound Healing Ctr, Med Ctr 4, 51 Fucheng Rd, Beijing 100048, Peoples R China.
   [Hong, Jingsong] Guangzhou Zhenggu Orthoped Hosp, Foot & Ankle Surg Dept, 449 Dongfeng Middle Rd, Guangzhou 510031, Peoples R China.
   [Hu, Dahai] Air Force Med Univ, Dept Burns & Cutaneous Surg, Affiliated Hosp 1, 127 West Changle Rd, Xian 710032, Peoples R China.
   [Jiang, Yufeng] PLA Strateg Support Force Characterist Med Ctr, Wound Healing Dept, 9 Anxiang North Lane, Beijing 100101, Peoples R China.
   [Ju, Shang] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Peripheral Vasc, Hai Yun Cang 5th, Beijing 100700, Peoples R China.
   [Li, Hongye] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Orthoped, Sch Med, 3 East Qinchun Rd, Hangzhou 310016, Peoples R China.
   [Li, Zongyu] Fifth Hosp Harbin, Dept Burns, 27 Jiankang Rd, Harbin 150030, Peoples R China.
   [Liang, Guangping; Luo, Gaoxing] Third Mil Med Univ, Southwest Hosp, Inst Burn Res, State Key Lab Trauma Burn & Combined Injury, Gaotanyan St 29, Chongqing 400038, Peoples R China.
   [Liu, Yan] Shanghai Jiao Tong Univ, Sch Med, Dept Burn, Affiliated Ruijin Hosp, 197 Ruijin Rd 2, Shanghai 200025, Peoples R China.
   [Lv, Guozhong] Third Peoples Hosp Wuxi, Dept Burn Surg, 585 North Xingyuan Rd, Wuxi 214043, Jiangsu, Peoples R China.
   [Ran, Xingwu] Sichuan Univ, West China Hosp, Innovat Ctr Wound Rpair, Diabet Foot Care Ctr,Dept Endocrinol & Metab, 37 Guoxue Lane, Chengdu, Peoples R China.
   [Shi, Zhongmin] Shanghai Jiao Tong Univ, Dept Orthoped, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China.
   [Tang, Juyu] Cent South Univ, Dept Hand & Microsurg, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Peoples R China.
   [Wang, Aiping] Air Force Hosp Eastern Theater PLA, Diabet Foot Ctr, 1 Malu Rd, Nanjing 210002, Ginhuai Distric, Peoples R China.
   [Wang, Jiangning] Capital Med Univ, Beijing Shijitan Hosp, Dept Orthoped Surg, 10 Tieyi Rd, Beijing 100038, Peoples R China.
   [Wang, Xin] Ningbo 6 Hosp, Dept Plast & Hand Surg, 1059 East Zhongshan Rd, Ningbo 315040, Peoples R China.
   [Wen, Bing] Peking Univ First Hosp, Diabet Foot Prevent & Treatment Ctr, Plast & Burn Surg Dept, 8 Xishiku St, Beijing 100034, Peoples R China.
   [Wu, Jun] Shenzhen Univ, Peoples Hosp Shenzhen 2, Dept Burn & Plast Surg, 3002 West Sungang Rd, Shenzhen 518037, Peoples R China.
   [Xu, Hailin] Peking Univ, Peking Univ Peoples Hosp, Dept Orthoped & Trauma, 11 Xizhimen South St, Beijing 100044, Peoples R China.
   [Xu, Hailin] Peking Univ, Peking Univ Peoples Hosp, Diabet Foot Treatment Ctr, 11 Xizhimen South St, Beijing 100044, Peoples R China.
   [Zhang, Yi] Nantong Univ, Dept Burn & Plast Surg, Affiliated Hosp, 20 Xisi Rd, Nantong 226001, Peoples R China.
C3 Naval Medical University; Fujian Medical University; Zhejiang
   University; Zhejiang University; Chinese People's Liberation Army
   General Hospital; Chinese People's Liberation Army General Hospital; Air
   Force Medical University; Beijing University of Chinese Medicine;
   Zhejiang University; Army Medical University; Shanghai Jiao Tong
   University; Jiangnan University; Sichuan University; Shanghai Jiao Tong
   University; Central South University; Capital Medical University;
   Shenzhen University; Peking University; Peking University; Nantong
   University
RP Xiao, SC; Xia, ZF (通讯作者)，Naval Med Univ, Burn Inst PLA, Dept Burns, Affiliated Hosp 1, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM huangzhuoxiao4@hotmail.com; xiazhaofan@163.com
RI Tang, Juyu/ABA-5676-2020; 刘, 琰/GVT-3050-2022; Jiang,
   Yufeng/AAV-5669-2020; Guangping, Liang/HLG-5911-2023; LUO,
   Gaoxing/AAE-4505-2020
OI ye, xiaofei/0000-0003-3692-1285; wu, jun/0000-0002-4997-1970; Ji,
   Shizhao/0000-0002-5083-288X; Shi, Zhongmin/0000-0002-6812-2659; LUO,
   Gaoxing/0000-0003-4764-3209
FU National Key R&D Program of China [2019YFA0110503]; National Natural
   Science Foundation of China [81930057, 81871559]
FX Research on in situ skin repair and regeneration based on micro-tissue
   engineering technology and 3D printing. (The National Key R&D Program of
   China, Grant Number 2019YFA0110503). The study on natural living
   microamniotic scaffolds to dynamic regulate immune inflammation and
   reconstruct wound repairing. (National Natural Science Foundation of
   China, Grant Number 81971836). The systemic study of miR-23b_24-1
   cluster in the prevention and treatment of MODS caused by sepsis after
   burns. (National Natural Science Foundation of China, Grant Number
   81930057). The experimental study on regulating the immune inflammatory
   microenvironment of burn wounds and promoting repair and regeneration
   based on microtissue engineering technology. (National Natural Science
   Foundation of China, Grant Number 81871559).
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NR 161
TC 66
Z9 99
U1 8
U2 119
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2321-3868
EI 2321-3876
J9 BURNS TRAUMA
JI Burns Trauma
PY 2021
VL 9
AR tkab018
DI 10.1093/burnst/tkab018
PG 12
WC Emergency Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Dermatology; Surgery
GA WM2QL
UT WOS:000710935200011
PM 34212064
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zeiderman, MR
   Pu, LLQ
AF Zeiderman, Matthew R.
   Pu, Lee L. Q.
TI Contemporary approach to soft-tissue reconstruction of the lower
   extremity after trauma
SO BURNS & TRAUMA
LA English
DT Review
DE Lower extremity; Soft tissue; Reconstruction; Trauma; Surgical approach
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; OPEN TIBIAL FRACTURES;
   FASCIOCUTANEOUS FREE FLAPS; THIGH PERFORATOR FLAPS; GUSTILO TYPE IIIB;
   LIMB SALVAGE; MICROSURGICAL RECONSTRUCTION; DOPPLER FLOWMETRY; MUSCLE
   FLAP
AB The complex lower extremity wound is frequently encountered by orthopedic and plastic surgeons. Innovations in wound care, soft tissue coverage and surgical fixation techniques allow for improved functional outcomes in this patient population with highly morbid injuries. In this review, the principles of reconstruction of complex lower extremity traumatic wounds are outlined. These principles include appropriate initial evaluation of the patient and mangled extremity, as well as appropriate patient selection for limb salvage. The authors emphasize proper planning for reconstruction, timing of reconstruction and the importance of an understanding of the most appropriate reconstructive option. The role of different reconstructive and wound care modalities is discussed, notably negative pressure wound therapy and dermal substitutes. The role of pedicled flaps and microvascular free-tissue transfer are discussed, as are innovations in understanding of perforator anatomy and perforator flap surgery that have broadened the reconstruction surgeon's armamentarium. Finally, the importance of a multidisciplinary team is highlighted via the principle of the orthoplastic approach to management of complex lower extremity wounds. Upon completion of this review, the reader should have a thorough understanding of the principles of contemporary lower extremity reconstruction.
C1 [Zeiderman, Matthew R.; Pu, Lee L. Q.] Univ Calif Davis, Dept Surg, Div Plast & Reconstruct Surg, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis
RP Pu, LLQ (通讯作者)，Univ Calif Davis, Dept Surg, Div Plast & Reconstruct Surg, Sacramento, CA 95817 USA.
EM llpu@ucdavis.edu
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NR 110
TC 37
Z9 63
U1 1
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2321-3868
EI 2321-3876
J9 BURNS TRAUMA
JI Burns Trauma
PY 2021
VL 9
AR tkab024
DI 10.1093/burnst/tkab024
EA JUL 2021
PG 13
WC Emergency Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Dermatology; Surgery
GA WM2QL
UT WOS:000710935200017
PM 34345630
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chetter, I
   Arundel, C
   Martin, BC
   Hewitt, C
   Fairhurst, C
   Joshi, K
   Mott, A
   Rodgers, S
   Goncalves, PS
   Torgerson, D
   Wilkinson, J
   Blazeby, J
   Macefield, R
   Dixon, S
   Henderson, E
   Oswald, A
   Dumville, J
   Lee, M
   Pinkney, T
   Stubbs, N
   Wilson, L
AF Chetter, Ian
   Arundel, Catherine
   Martin, Belen Corbacho
   Hewitt, Catherine
   Fairhurst, Caroline
   Joshi, Kalpita
   Mott, Andrew
   Rodgers, Sara
   Goncalves, Pedro Saramago
   Torgerson, David
   Wilkinson, Jacqueline
   Blazeby, Jane
   Macefield, Rhiannon
   Dixon, Stephen
   Henderson, Eileen
   Oswald, Angela
   Dumville, Jo
   Lee, Matthew
   Pinkney, Thomas
   Stubbs, Nikki
   Wilson, Lyn
TI Negative pressure wound therapy versus usual care for surgical wounds
   healing by secondary intention (SWHSI-2 trial): study protocol for a
   pragmatic, multicentre, cross surgical specialty, randomised controlled
   trial
SO TRIALS
LA English
DT Article
DE Surgical wounds; Negative pressure wound therapy; Secondary intention;
   Wound healing; Randomised controlled trial
ID ALGINATE; CLOSURE
AB Background: The majority of surgical wounds are closed (for example with sutures or staples) and so heal by primary intention. Where closure is not possible, or the wound subsequently breaks down, wounds may be left to heal from the bottom up (healing by secondary intention). Surgical wound healing by secondary intention (SWHSI) frequently presents a significant management challenge. Additional treatments are often required during the course of healing, and thus a significant financial burden is associated with treating these wounds. Increasingly, negative pressure wound therapy (NPWT) is used in the management of SWHSI. This wound dressing system provides a negative pressure (vacuum) to the wound, removing fluid into a canister, which is believed to be conducive to wound healing. Despite the increasing use of NPWT, there is limited robust evidence for the effectiveness of this device. A well-designed and conducted randomised controlled trial is now required to ascertain if NPWT is a clinically and cost-effective treatment for SWHSI.
   Methods: SWHSI-2 is a pragmatic, multi-centre, cross surgical specialty, two arm, parallel group, randomised controlled superiority trial. Adult patients with a SWHSI will be randomised to receive either NPWT or usual care (no NPWT) and will be followed up for 12 months. The primary outcome will be time to healing (defined as full epithelial cover in absence of a scab) in number of days since randomisation. Secondary outcomes will include key clinical events (hospital admission or discharge, treatment status, reoperation, amputation, antibiotic use and death), wound infection, wound pain, health-related quality of life, health utility and resource use.
   Discussion: Given the increasing use of NPWT, despite limited high-quality supporting evidence, the SWHSI-2 Trial will provide robust evidence on the clinical and cost-effectiveness of NPWT in the management of SWHSI. The SWHSI-2 Trial opened to recruitment in May 2019 and is currently recruiting across 20 participating centres.
C1 [Chetter, Ian; Arundel, Catherine; Martin, Belen Corbacho; Hewitt, Catherine; Fairhurst, Caroline; Joshi, Kalpita; Mott, Andrew; Rodgers, Sara; Goncalves, Pedro Saramago; Torgerson, David; Wilkinson, Jacqueline; Blazeby, Jane; Macefield, Rhiannon; Dixon, Stephen; Henderson, Eileen; Oswald, Angela; Dumville, Jo; Lee, Matthew; Pinkney, Thomas; Stubbs, Nikki; Wilson, Lyn] Univ York, Fac Sci, Dept Hlth Sci, York Trials Unit, Lower Ground Floor ARRC Bldg, York YO10 5DD, N Yorkshire, England.
C3 University of York - UK
RP Chetter, I (通讯作者)，Univ York, Fac Sci, Dept Hlth Sci, York Trials Unit, Lower Ground Floor ARRC Bldg, York YO10 5DD, N Yorkshire, England.
EM catherine.arundel@york.ac.uk
RI ; Blazeby, Jane/H-6703-2019; Dumville, Jo/O-7867-2014; Pinkney,
   Thomas/HGA-4022-2022; Mott, Andrew/HLQ-6922-2023; Torgerson,
   David/L-4566-2019
OI Wilkinson, Jacqueline/0000-0003-4543-2109; Blazeby,
   Jane/0000-0002-3354-3330; chetter, ian/0000-0002-2566-6859; Arundel,
   Catherine/0000-0003-0512-4339; Dumville, Jo/0000-0002-6546-3685;
   Macefield, Rhiannon/0000-0002-6606-5427; Pinkney,
   Thomas/0000-0001-7320-6673; Mott, Andrew/0000-0001-7844-9033; Hewitt,
   Catherine Elizabeth/0000-0002-0415-3536
FU National Institute for Health Research (NIHR) Health Technology
   Assessment Programme [17/42/94]; National Institutes of Health Research
   (NIHR) [17/42/94] Funding Source: National Institutes of Health Research
   (NIHR); Medical Research Council [MR/K025643/1] Funding Source:
   researchfish; MRC [MR/K025643/1] Funding Source: UKRI
FX This project was funded by the National Institute for Health Research
   (NIHR) Health Technology Assessment Programme (project reference
   17/42/94). The views expressed are those of the author(s) and not
   necessarily those of the NIHR or the Department of Health and Social
   Care. JB is an NIHR senior investigator.
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NR 29
TC 11
Z9 12
U1 1
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD OCT 25
PY 2021
VL 22
IS 1
AR 739
DI 10.1186/s13063-021-05662-2
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA WM3EW
UT WOS:000710972800004
PM 34696784
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Chung, JNC
   Ali, O
   Hawthornthwaite, E
   Watkinson, T
   Blyth, U
   McKigney, N
   Harji, DP
   Griffiths, B
AF Chung, Jordan Ng Cheong
   Ali, Omar
   Hawthornthwaite, Emma
   Watkinson, Thomas
   Blyth, Ursula
   McKigney, Niamh
   Harji, Deena P.
   Griffiths, Ben
TI Closed incision negative pressure wound therapy is associated with
   reduced surgical site infection after emergency laparotomy: A propensity
   matched-cohort analysis
SO SURGERY
LA English
DT Article
ID ABDOMINAL-SURGERY; COMPLICATIONS; PREVENTION; MORBIDITY
AB Background: Surgical site infection contributes to a significant proportion of postoperative morbidity in patients undergoing emergency laparotomy. Surgical site infections cause significant patient burden, increase duration of stay, and have economic implications. Closed incision negative pressure therapy has been shown to reduce surgical site infection rates in patients undergoing elective laparotomy; however, there is limited evidence for their use in the emergency setting. This study aims to compare rates of surgical site infection between patients receiving closed incision negative pressure therapy and standard surgical dressing after emergency laparotomy through a propensity matched analysis. Methods: A registry-based, prospective cohort study was undertaken using data from the National Emergency Laparotomy Audit database at our center. The primary outcome measure was surgical site infection as defined by the Centers for Disease Control criteria. Secondary outcomes included 30-day postoperative morbidity and grade, duration of stay, 30-day mortality, and readmission rates. A propensity-score matching was performed in a 1:1 ratio to mitigate for selection bias. Results: A total of 1,484 patients were identified from the National Emergency Laparotomy Audit data set, and propensity-score matching resulted in 2 equally matched cohorts with 237 patients in each arm. The rate of surgical site infection was significantly lower in the closed incision negative pressure therapy cohort (16.9% vs 33.8%, P < .001). There were no overall differences in 30-day morbidity, Clavien-Dindo grade, Comprehensive Complication Index severity, length of hospital stay, reoperation rates, and 30-day mortality between the 2 groups. Conclusions: Prophylactic closed incision negative pressure therapy in emergency laparotomy patients is associated with a reduction in surgical site infection rates. (c) 2021 Elsevier Inc. All rights reserved.
C1 [Chung, Jordan Ng Cheong; Ali, Omar] Newcastle Univ, Med Sch, Newcastle Upon Tyne, Tyne & Wear, England.
   [Hawthornthwaite, Emma; Watkinson, Thomas; Blyth, Ursula; McKigney, Niamh; Harji, Deena P.] Hlth Educ North East, Waterfront 4 Goldcrest Way, Newcastle Upon Tyne NE15 8NY, Tyne & Wear, England.
   [Griffiths, Ben] Royal Victoria Infirm, Dept Colorectal Surg, Newcastle Upon Tyne, Tyne & Wear, England.
C3 Newcastle University - UK; Newcastle University - UK
RP Harji, DP (通讯作者)，Hlth Educ North East, Waterfront 4 Goldcrest Way, Newcastle Upon Tyne NE15 8NY, Tyne & Wear, England.
EM deena.harji@nhs.nt
RI ; Harji, Deena/AAZ-2428-2020
OI Blyth, Ursula/0000-0001-6846-8687; Ali, Omar/0000-0003-3741-0815;
   Griffiths, Ben/0000-0002-8745-1861; McKigney, Niamh
   Aine/0000-0003-1599-5701; 
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NR 28
TC 15
Z9 15
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD NOV
PY 2021
VL 170
IS 5
BP 1568
EP 1573
DI 10.1016/j.surg.2021.04.009
EA OCT 2021
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WM3NW
UT WOS:000710996400042
PM 34052025
DA 2026-07-24
ER
PT J
AU Peterson, AT
   Bakaysa, SL
   Driscoll, JM
   Kalyanaraman, R
   House, MD
AF Peterson, Ashley T.
   Bakaysa, Stephanie L.
   Driscoll, Janelle M.
   Kalyanaraman, Rajeshwari
   House, Michael D.
TI Randomized controlled trial of single-use negative-pressure wound
   therapy dressings in morbidly obese patients undergoing cesarean
   delivery
SO AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
LA English
DT Article
DE cesarean; negative-pressure wound therapy; obesity; wound complications
ID SURGICAL-SITE INFECTION; RISK; COMPLICATIONS; WOMEN; PREVENTION
AB BACKGROUND: The single-use negative-pressure wound therapy dressings are designed to use over a closed surgical wound. Early prospective studies suggested that these dressings may be of potential benefit in reducing cesarean wound complications.
   OBJECTIVE: This study aimed to test the hypothesis that incisional negative-pressure wound therapy decreases postoperative wound morbidity compared with standard surgical dressing in patients with class III obesity undergoing cesarean delivery.
   STUDY DESIGN: In a single-site, parallel, randomized controlled trial, participants with class III obesity (body mass index >= 40 kg/m(2)) were recruited to participate in the study. Patients were consented in the ambulatory obstetrical units, on admission to the antepartum service, and on labor and delivery before active labor. Patients who had a cesarean delivery were randomized to either the standard surgical dressing or a prophylactic negative-pressure wound therapy device. The randomization was achieved using permuted blocks of 4, 6, and 8 in a 1:1 allocation ratio. The primary outcome was a composite outcome of wound complications. The planned enrollment of 242 subjects was based on the power to detect a 50% decrease in the composite wound outcome, assuming a 30% baseline wound morbidity rate for this population. The outcomes were assessed by study staff blinded to the patient's treatment arm.
   RESULTS: An unplanned interim analysis was performed because of the slow enrollment and publication of larger trials showing no benefit of the negative-pressure wound therapy. Of 411 eligible patients during the study period, 212 participants with class III obesity were enrolled. Of these, 110 underwent cesarean delivery and were subsequently randomized (55 to standard dressing and 55 to prophylactic negative-pressure wound therapy device). The primary outcome occurred in 29.1% in the standard surgical dressing compared with 20% in the negative-pressure wound therapy group (risk difference, 9.1%; 95% confidence interval, -8.3 to 25.8%; P=.38). The study was stopped early because of a low enrollment rate and lower likelihood of seeing a clinically significant benefit.
   CONCLUSION: The trial was stopped after an unplanned, interim analysis showed the use of a prophylactic negative-pressure wound therapy device used for cesarean delivery did not reduce wound complications compared with a standard surgical dressing.
C1 [Peterson, Ashley T.; Bakaysa, Stephanie L.; House, Michael D.] Tufts Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Boston, MA 02111 USA.
   [Driscoll, Janelle M.; Kalyanaraman, Rajeshwari] Tufts Med Ctr, Dept Obstet & Gynecol, Boston, MA 02111 USA.
   [House, Michael D.] Tufts Med Ctr, Mother Infant Res Inst, Boston, MA 02111 USA.
   [Bakaysa, Stephanie L.] Hartford Hosp, Div Maternal Fetal Med, Dept Obstet & Gynecol, Hartford, CT 06115 USA.
   [Kalyanaraman, Rajeshwari] St Francis Hosp & Med Ctr, Dept Obstet & Gynecol, Hartford, CT USA.
C3 Tufts Medical Center; Tufts Medical Center; Tufts Medical Center;
   Hartford Hospital; Saint Francis Hospital & Medical Center
RP Peterson, AT (通讯作者)，Tufts Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Boston, MA 02111 USA.
EM apeterson@tuftsmedicalcenter.org
RI /AAC-3371-2020; House, Michael/HPH-2039-2023
OI House, Michael/0000-0002-4274-5786; Peterson, Ashley/0000-0002-3971-4567
CR Conner SN, 2014, AM J PERINAT, V31, P299, DOI 10.1055/s-0033-1348402
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NR 25
TC 10
Z9 11
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29a, 1043 NX AMSTERDAM, NETHERLANDS
SN 2589-9333
J9 AM J OBST GYNEC MFM
JI Amer. J. Obstet. Gynecol. MFM
PD SEP
PY 2021
VL 3
IS 5
AR 100410
DI 10.1016/j.ajogmf.2021.100410
EA JUL 2021
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA WM7BK
UT WOS:000711236400037
PM 34058423
DA 2026-07-24
ER
PT J
AU Annacontini, L
   Verdura, V
   Cecchino, LR
   Lembo, F
   Florio, AM
   Parisi, D
   Nicoletti, GF
   Portincasa, A
AF Annacontini, Luigi
   Verdura, Vincenzo
   Cecchino, Liberato R.
   Lembo, Fedele
   Florio, Andrea M.
   Parisi, Domenico
   Nicoletti, Giovanni F.
   Portincasa, Aurelio
TI Cling Wrap Technique: An Inexpensive and Simple Way to Seal Negative
   Pressure Wound Therapy on External Fixation Devices
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy; external fixation; vacuum sealing
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTION
AB Negative pressure therapy is often applied to treat limb traumas with or without bone exposure. However, sealing a negative pressure dressing in the presence of an external fixation device may be complicated and time consuming. In this technique, we attempted to maintain vacuum conditions by preventing air leakage around the screws using plastic drape and cling wrap as the final layer over the external fixation device. To prevent rupturing of the wrap, the prominences of the pins and rods were covered using cotton wool roll. This novel solution is also effective for complex and extended wounds, with no need for additional dressing changes and no occurrence of complications for approximately 4 days. Furthermore, it is an inexpensive, quick, and readily available technique requiring minimal training to perform. It is also adaptable to any anatomical region, allowing the inspection of the limb when required.
C1 [Annacontini, Luigi; Cecchino, Liberato R.; Lembo, Fedele; Parisi, Domenico; Portincasa, Aurelio] Univ Hosp Foggia, Dept Plast & Reconstruct Surg, Foggia, Italy.
   [Verdura, Vincenzo; Florio, Andrea M.; Nicoletti, Giovanni F.] Univ Study Campania Luigi Vanvitelli, Multidisciplinary Dept Med Surg & Dent Specialtie, Plast Surg Unit, Naples, Italy.
C3 University of Foggia; Universita della Campania Vanvitelli
RP Verdura, V (通讯作者)，Via Michele Pellicani 16-M, I-70037 Ruvo Di Puglia, BA, Italy.
EM vincenzo.verdura89@gmail.com
RI /Q-8775-2018; /A-7943-2013; Nicoletti, Giovanni Federico/AAP-6739-2020;
   LEMBO, FEDELE/IUQ-0536-2023
OI LEMBO, FEDELE/0000-0003-0782-6406; PARISI, DOMENICO/0000-0002-7755-9115
CR British Association of Reconstructive and Aesthetic Surgeons, 2009, STANDARDS MANAGEMENT
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NR 14
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD OCT
PY 2021
VL 35
IS 10
BP E389
EP E391
DI 10.1097/BOT.0000000000002057
PG 3
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA WN5AP
UT WOS:000711780600006
PM 33813541
DA 2026-07-24
ER
PT J
AU Gioco, R
   Sanfilippo, C
   Veroux, P
   Corona, D
   Privitera, F
   Brolese, A
   Ciarleglio, F
   Volpicelli, A
   Veroux, M
AF Gioco, Rossella
   Sanfilippo, Claudio
   Veroux, Pierfrancesco
   Corona, Daniela
   Privitera, Francesca
   Brolese, Alberto
   Ciarleglio, Francesco
   Volpicelli, Alessio
   Veroux, Massimiliano
TI Abdominal wall complications after kidney transplantation: A clinical
   review
SO CLINICAL TRANSPLANTATION
LA English
DT Review
DE biological mesh; component separation; dehiscence; immunosuppression;
   Incisional hernia; infection; kidney transplantation; laparoscopic;
   mesh; negative pressure wound therapy; open; pancreas; paratransplant
   hernia; primary suture; transplantation; wound
ID INCISIONAL HERNIA REPAIR; WOUND-HEALING COMPLICATIONS; RANDOMIZED
   CONTROLLED-TRIAL; DELAYED GRAFT FUNCTION; HOOD FASCIAL CLOSURE;
   RISK-FACTORS; MYCOPHENOLATE-MOFETIL; RENAL-TRANSPLANTATION;
   PARATRANSPLANT HERNIA; POLYPROPYLENE MESH
AB Introduction Abdominal wall complications are common after kidney transplantation, and although they have a minor impact on patient and graft survival, they increase the patient's morbidity and may have an impact on quality of life. Abdominal wall complications have an overall incidence of 7.7-21%. Methods This review will explore the natural history of abdominal wall complications in the kidney transplant setting, with a special focus on wound dehiscence and incisional herni, with a particular emphasis on risk factors, clinical characteristics, and treatment. Results Many patient-related risk factors have been suggested, including older age, obesity, and smoking, but kidney transplant recipients have an additional risk related to the use of immunosuppression. Wound dehiscence usually does not require surgical intervention. However, for deep dehiscence involving the fascial layer with concomitant infection, surgical treatment and/or negative pressure wound therapy may be required. Conclusions Incisional hernia (IH) may affect 1.1-18% of kidney transplant recipients. Most patients require surgical treatment, either open or laparoscopic. Mesh repair is considered the gold standard for the treatment of IH, since it is associated with a low rate of postoperative complications and an acceptable rate of recurrence. Biologic mesh could be an attractive alternative in patients with graft exposition or infection.
C1 [Gioco, Rossella; Privitera, Francesca; Volpicelli, Alessio; Veroux, Massimiliano] Univ Hosp Catania, Gen Surg Unit, Catania, Italy.
   [Sanfilippo, Claudio] Univ Hosp Catania, Cardiol Unit, Catania, Italy.
   [Veroux, Pierfrancesco; Veroux, Massimiliano] Univ Hosp Catania, Organ Transplant Unit, Catania, Italy.
   [Corona, Daniela] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy.
   [Brolese, Alberto; Ciarleglio, Francesco] Trento Hosp, Surg Unit, Trento, Italy.
C3 University of Catania; University Catania Hospital; University of
   Catania; University Catania Hospital; University of Catania; University
   Catania Hospital; University of Catania
RP Veroux, M (通讯作者)，Univ Hosp Catania, Organ Transplant Unit, Dept Med & Surg Sci & Adv Technol, Via Santa Sofia, I-8495123 Catania, Italy.
EM veroux@unict.it
RI ; Veroux, Massimiliano/K-4821-2018; Veroux, Pierfrancesco/K-5195-2018;
   Ciarleglio, Francesco/ABD-1681-2020
OI Privitera, Francesca/0000-0003-0654-3789; Veroux,
   Massimiliano/0000-0002-2780-6421; Sanfilippo,
   Claudio/0000-0002-1508-4927; Gioco, Rossella/0000-0003-3608-6187
FU Specialty School of General Surgery of the University of Catania;
   University of Catania [FIR-14]
FX The authors thank Dr. Grazia Strazzeri and Dr Domenico Zerbo for their
   valuable contribution in preparing the figures of the manuscript. This
   study was supported by This manuscript was funded by the Specialty
   School of General Surgery of the University of Catania and by the FIR-14
   Research Project of the University of Catania.
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NR 127
TC 19
Z9 24
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0902-0063
EI 1399-0012
J9 CLIN TRANSPLANT
JI Clin. Transplant.
PD DEC
PY 2021
VL 35
IS 12
AR e14506
DI 10.1111/ctr.14506
EA OCT 2021
PG 15
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA XS1UL
UT WOS:000712126900001
PM 34634148
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Braun, G
   Muck, A
AF Braun, Georg
   Muck, Alexander
TI Endoscopy on the surgical intensive care unit
SO ANAESTHESIST
LA German
DT Article
DE Enteral nutrition; Tube feeding; Endoscopic vacuum therapy; Anastomotic
   leakage; Endoscopic decompression
ID VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE; GERMAN SOCIETY; THERAPY;
   ESOPHAGEAL; GASTROENTEROLOGY; RESECTION; DRAINAGE
AB Endoscopy is most frequently performed in intensive care units (ICU) for gastrointestinal bleeding; however, there are other indications for performing an endoscopy on the ICU. This article shows the indications for this, the background and the peri-interventional and postinterventional management. The endoscopic placement of a postpyloric feeding tube is a well-established procedure. For anastomotic leakage in the esophagus and rectum, the endoscopic vacuum therapy is the treatment of choice. Gastrointestinal motility disorders are a frequent phenomenon in critically ill patients and are associated with increased mortality. With a cecal diameter > 9-12 mm, endoscopic decompression can be performed; however, this is associated with an increased risk of perforation and should only be carried out after the failure of conservative treatment.
C1 [Braun, Georg; Muck, Alexander] Univ Klinikum Augsburg, Klin Anasthesiol & Operat Intens Med, Medi Klin 3, Stenglinstr 2, D-86156 Augsburg, Germany.
RP Braun, G (通讯作者)，Univ Klinikum Augsburg, Klin Anasthesiol & Operat Intens Med, Medi Klin 3, Stenglinstr 2, D-86156 Augsburg, Germany.
EM georg.braun@uk-augsburg.de
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NR 40
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0003-2417
EI 1432-055X
J9 ANAESTHESIST
JI Anaesthesist
PD NOV
PY 2021
VL 70
IS 11
SI SI
BP 977
EP 990
DI 10.1007/s00101-021-01047-x
EA OCT 2021
PG 14
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA WR2YB
UT WOS:000712177000002
PM 34709412
DA 2026-07-24
ER
PT J
AU Wei, ZY
   Zhu, JF
   Lin, TL
   Cai, HH
   Fang, XJ
   Zhu, YX
   Yang, XL
   Cheng, JT
AF Wei, Zhiyi
   Zhu, Jingfa
   Lin, Tianlai
   Cai, Hehui
   Fang, Xiangjian
   Zhu, Yixin
   Yang, Xiaolan
   Cheng, Juntao
TI Application of damage control surgery in patients with sacrococcygeal
   deep decubitus ulcers complicated by sepsis
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Sacrococcygeal deep decubitus ulcer; sepsis; damage control surgery;
   modified rhomboid flap; vacuum sealing drainage; bedsore
ID DESIGN; FLAP
AB Objective To evaluate the clinical application of damage control surgery (DCS) in patients with sacrococcygeal deep decubitus ulcers complicated by sepsis. Methods We conducted a 3-year retrospective clinical study of 32 patients with deep sacrococcygeal bedsores and sepsis admitted from January 2018 to January 2021. According to the concept of DCS, the wound was temporarily closed with vacuum sealing drainage after primary debridement, and a local rhomboid flap was designed to repair the wound in the second stage. Finally, the clinical therapeutic effect was observed. Results Twenty-nine patients were treated with skin flap translocation and were cured clinically. Specifically, the skin flap survived in 27 of the 29 patients after the first translocation attempt (success rate of 93.1%). One patient developed incisional dehiscence, and one patient developed a hydrocele under the skin flap. Conclusions Application of DCS in patients with sacrococcygeal deep decubitus ulcers complicated by sepsis improves the therapeutic success rate and reduces the risks of the operation and complication rate. It has unique advantages and is worthy of clinical promotion.
C1 [Wei, Zhiyi; Fang, Xiangjian; Zhu, Yixin; Yang, Xiaolan; Cheng, Juntao] Quanzhou First Hosp, Dept Burn Intens Care Unit, 250 Dongjie Rd, Quanzhou 362000, Fujian, Peoples R China.
   [Zhu, Jingfa] Quanzhou First Hosp, Dept Emergency, Quanzhou, Fujian, Peoples R China.
   [Lin, Tianlai] Quanzhou First Hosp, Dept Intens Care Unit, Quanzhou, Fujian, Peoples R China.
   [Cai, Hehui] Quanzhou First Hosp, Dept Med Lab, Quanzhou, Fujian, Peoples R China.
RP Cheng, JT (通讯作者)，Quanzhou First Hosp, Dept Burn Intens Care Unit, 250 Dongjie Rd, Quanzhou 362000, Fujian, Peoples R China.
EM c5481@sina.com
OI Yang, Xiaolan/0000-0003-4177-5921; Cheng, Juntao/0000-0002-4236-3817
CR Chou CY, 2018, OSTOMY WOUND MANAG, V64, P40, DOI 10.25270/owm.2018.3.4044
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NR 20
TC 3
Z9 3
U1 0
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD OCT
PY 2021
VL 49
IS 10
AR 03000605211049876
DI 10.1177/03000605211049876
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA WP7TV
UT WOS:000713330000001
PM 34719986
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kashimura, T
   Yoshida, K
   Soejima, K
AF Kashimura, Tsutomu
   Yoshida, Kotoku
   Soejima, Kazutaka
TI A Novel Technique of Negative Pressure Wound Therapy for Pharyngeal
   Cutaneous Fistulas Around Tracheostomas
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Esophago-jejunal anastomosis; free jejunal transplantation; negative
   pressure wound therapy; pharyngeal cutaneous fistula; tracheostoma
ID CLOSURE
AB Fistula formation after free jejunal transplantation is relatively common; however, treating esophago-jejunal anastomosis fistulas is difficult. Herein, the authors report a case of esophago-jejunal anastomosis fistula adjacent to the permanent tracheostoma after free jejunal transplantation that was closed using negative pressure wound therapy (NPWT). A 70-year-old man underwent total pharyngo-laryngo-cervical esophagectomy and free jejunal transplantation for hypopharyngeal cancer. After reconstruction, an esophago-jejunal anastomosis fistula developed on the permanent tracheostoma margin. The fistula was sutured, but it recurred. Therefore, NPWT was performed to close the fistula via the bridge method and balloon compression using a tracheal cannula. NPWT requires the maintenance of local negative pressure. However, esophago-jejunal anastomosis fistula formation after free jejunal transplantation makes this difficult because of the unevenness of the permanent tracheostoma and moist surface of the tracheal mucosa. NPWT performed using the bridge method and balloon compression is an effective option for fistula treatment.
C1 [Kashimura, Tsutomu; Yoshida, Kotoku; Soejima, Kazutaka] Nihon Univ, Sch Med, Dept Plast & Reconstruct Surg, Tokyo, Japan.
C3 Nihon University
RP Kashimura, T (通讯作者)，Nihon Univ, Sch Med, Dept Plast & Reconstruct Surg, Itabashi Ku, 30-1 Ooyaguchikami Cho, Tokyo 1738610, Japan.
EM kashimura.tsutomu@nihon-u.ac.jp
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NR 8
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD NOV-DEC
PY 2021
VL 32
IS 8
BP E765
EP E767
DI 10.1097/SCS.0000000000007763
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WP8DF
UT WOS:000713355900046
PM 34224456
DA 2026-07-24
ER
PT J
AU Xu, X
   Sun, YH
AF Xu, Xin
   Sun, Yanhua
TI Nursing countermeasures for VSD treatment of orthopedic trauma and
   infected wounds
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Vacuum sealing drainage; trauma infection; pain level; satisfaction;
   size of trauma; quality of life
ID PREVENTION; CARE
AB Objective: This study intended to investigate the effect of vacuum sealing drainage (VSD) in the treatment of orthopedic trauma and its role in the clinical care. Methods: A total of 104 patients with orthopedic trauma infection admitted to our hospital from January 2019 to January 2020 were divided into control group (n=53, receiving VSD) and study group (n=51, receiving VSD and nursing interventions) by random number table. Surgical outcomes, satisfaction, size of trauma and visual analogue scoring scale (VAS) scores were compared between the two groups. Results: The study group had shorter time to achieve granulation tissue coverage of wound base, trauma recovery and hospital stay than the control group (P<0.05). The satisfaction rate in the study group was higher compared with that in the control group (P<0.05). Before intervention, the VAS scores of the two groups and size of trauma were not significantly different (P>0.05). After intervention, VAS scores were significantly lower and trauma area was significantly smaller in both groups, and the difference was more pronounced in the study group compared with that in the control group (P<0.05). Quality of life scores were higher in the study group compared with the control group (P<0.05). Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels were lower in the study group compared with those in the control group (P<0.05). Packed cell volume (PCV), plasma viscosity, and low-cut versus high-cut whole blood viscosity were lower in the study group compared with those in the control group (P<0.05). Conclusion: VSD treatment combined with clinical nursing interventions in patients with orthopedic trauma infection could shorten the time to granulation coverage, wound healing and hospitalization time, and improve indicators of blood rheology. It could also shrink the size of trauma, decrease the level of pain and inflammatory factors, and improve the quality of life, resulting in high satisfaction.
C1 [Xu, Xin; Sun, Yanhua] Huzhou Univ, Affiliated Cent Hosp, Huzhou Cent Hosp, Dept Orthoped, Huzhou 313000, Zhejiang, Peoples R China.
C3 Huzhou University
RP Sun, YH (通讯作者)，Huzhou Univ, Affiliated Cent Hosp, Huzhou Cent Hosp, Dept Orthoped, Huzhou 313000, Zhejiang, Peoples R China.
EM sunyanhualv@163.com
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NR 29
TC 4
Z9 7
U1 1
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2021
VL 13
IS 9
BP 10625
EP 10632
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Research & Experimental Medicine
GA WQ0UG
UT WOS:000713537400038
PM 34650735
DA 2026-07-24
ER
PT J
AU Nieminen, VJ
   Jääskelainen, IH
   Eklund, AM
   Murto, ES
   Mattila, KJ
   Juvonen, TS
   Vento, AE
   Järvinen, AI
AF Nieminen, Ville J.
   Jaaskelainen, Iiro H.
   Eklund, Anne M.
   Murto, Emilia S.
   Mattila, Kimmo J.
   Juvonen, Tatu S.
   Vento, Antti E.
   Jarvinen, Asko I.
TI The Characteristics of Postoperative Mediastinitis During the Changing
   Phases of Cardiac Surgery
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID RISK-FACTORS; INFECTIONS
AB Background. Mediastinitis is a serious complication of open heart surgery associated with high mortality, considerable health care costs, and prolonged hospital stay. We examined characteristics and incidence of mediastinitis during 29 years when indications and patient material have been in a process of change.
   Methods. This was a retrospective population-based study comprising all mediastinitis patients more than 16 years of age after open heart surgery between 1990 and 2018 from a population of 1.7 million. Patient records of 50 mediastinitis patients from 2004 to 2014 were reviewed and compared with 120 patients from 1990 to 1999.
   Results. Annual mediastinitis rate varied 0% to 1.5% with a decreasing trend-from a level exceeding 1.2% to approximately 0.3%-over the study period. In 2004 to 2014 patients with mediastinitis were older, more often smokers, and more often had diabetes mellitus and renal insufficiency than in 1990 to 1999. No difference in length of hospital treatment, antibiotic prophylaxis or treatment, intensive care unit treatment, or mortality was observed between 1990 to 1999 and 2004 to 2014. Coronary artery bypass graft surgery became less common and valve replacement and hybrid operations more common among operations leading to mediastinitis. Staphylococcus aureus increased (from 25% to 56%, p = .005) whereas coagulase-negative staphylococci (46% to 23%, P < .001) and gramnegative bacteria (18% to 12%, P = .033) decreased as causative agents. Surgery for mediastinitis remained similar except introduction of vacuum-assisted closure treatment.
   Conclusions. The rate of mediastinitis decreased during these 29 years. No difference in 30-day mortality in mediastinitis was seen: 0.9% in 1990 to 1999 and 2% in 2004 to 2014. (C) 2021 by The Society of Thoracic Surgeons
C1 Univ Helsinki, Helsinki Univ Hosp, Dept Infect Dis, Inflammat Ctr, Helsinki, Finland.
   Univ Helsinki, Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.
C3 University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; Helsinki University Central Hospital
RP Jääskelainen, IH (通讯作者)，Helsinki Univ Hosp, Dept Infect Dis, POB 348, Helsinki 00029, Finland.
EM iiro.jaaskelainen@hus.fi
OI Järvinen, Asko/0000-0002-1906-7665
CR Abboud CS, 2004, ANN THORAC SURG, V77, P676, DOI 10.1016/S0003-4975(03)01523-6
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NR 28
TC 8
Z9 11
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2021
VL 112
IS 4
BP 1250
EP 1256
DI 10.1016/j.athoracsur.2020.10.029
EA SEP 2021
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA WQ2CC
UT WOS:000713627000037
PM 33248999
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Gao, HQ
   Cheng, XH
   Gao, LJ
   Wang, W
   Wang, XQ
   Gong, FR
   Zhang, MM
   Hu, J
AF Gao, Hengqing
   Cheng, Xiaohong
   Gao, Lijuan
   Wang, Wei
   Wang, Xiaoqiang
   Gong, Furao
   Zhang, Mengmeng
   Hu, Jing
TI Time-scheduled dotted and solid thread-ligating therapy combined with
   vacuum sealing drainage for treating high complex anal fistula
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Time-scheduled dotted and solid thread-ligating; vacuum sealing
   drainage; clinical efficacy; anal function
ID RESOLUTION ANORECTAL MANOMETRY; MANAGEMENT
AB Objective: To investigate the treatment of high complex anal fistula with time-scheduled dotted and solid thread-ligating therapy combined with vacuum sealing drainage. Methods: A retrospective cohort study of 80 patients with high complex anal fistula admitted to the anorectal department of our hospital was conducted. The patients in the control group (n=40) were treated with traditional incision thread-ligating therapy, while the patients in the observation group (n=40) were treated with time-scheduled dotted and solid thread-ligating therapy combined with vacuum sealing drainage. The postoperative wound healing time, clinical efficacy, postoperative pain scores as well as pre- and postoperative anal function and anorectal pressure of patients in the two groups were observed. Results: The observation group had a shorter wound healing time (P<0.001), lower postoperative pain scores (P<0.05), a lower increase of Wexner score (P<0.001), a higher total effective rate (97.50% vs. 90.00%; P>0.05), a higher anal maximal contraction pressure and a larger high pressure zone than the control group (P<0.05). Compared with those before operation, the Wexner scores of patients in the two groups after operation were increased, while the anal maximal contraction pressure and high pressure zone in the control group were decreased (P<0.001). Conclusion: The treatment of complex high anal fistula with time-scheduled dotted and solid thread-ligating combined with vacuum sealing drainage has short wound healing time, high efficiency, and little influence on the postoperative function of anal sphincter. It is worthy to be popularized in clinic.
C1 [Gao, Hengqing; Gao, Lijuan; Wang, Wei; Wang, Xiaoqiang; Gong, Furao] Zigong Hosp Chinese Tradit Med, Dept Anorectal, Zigong 643010, Sichuan, Peoples R China.
   [Cheng, Xiaohong] Zigong Hosp Chinese Tradit Med, Dept Pharm, Zigong 643010, Sichuan, Peoples R China.
   [Hu, Jing] Zigong Hosp Chinese Tradit Med, Dept Sci & Educ, Zigong 643010, Sichuan, Peoples R China.
   [Zhang, Mengmeng] Chengdu Univ Tradit Chinese Med, Grad Sch, 37 Twelve Bridge Rd, Chengdu 610072, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Zhang, MM (通讯作者)，Chengdu Univ Tradit Chinese Med, Grad Sch, 37 Twelve Bridge Rd, Chengdu 610072, Sichuan, Peoples R China.
EM zhangmengmeng512@163.com
RI wang, xiaoqiang/LXV-9628-2024
FU Special Pro-ject of Sichuan Provincial Administration of Traditional
   Chinese Medicine (Sichuan Traditional Chinese Medicine Office) [22-444]
FX This work was supported by the Special Pro-ject of Sichuan Provincial
   Administration of Traditional Chinese Medicine (Sichuan Traditional
   Chinese Medicine Office No. 22-444, 2020) .
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NR 25
TC 3
Z9 5
U1 0
U2 16
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2021
VL 13
IS 10
BP 11737
EP 11744
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA WR8WN
UT WOS:000714775300026
PM 34786101
DA 2026-07-24
ER
PT J
AU Zhu, ZH
   Zhao, JJ
   Zuo, ZC
   Zhou, KL
AF Zhu, Zhenhua
   Zhao, Jiaju
   Zuo, Zhicheng
   Zhou, Kailong
TI Repair of tophus wound of the heel with sural nerve nutrition flap with
   peroneal artery perforating branch: a retrospective study
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE Peroneal artery perforator; sural nerve flap; tophus; wounds
AB Background: This study was to investigate the clinical effect of a sural nerve nutrition flap with peroneal artery perforator for repairing tophus wound of the heel.
   Methods: Over a 5-year period, 7 elderly male patients with tophus ulceration of the heel were admitted with exposed Achilles' tendon, and a chronic unhealed wound. Debridement, expansion and vacuum sealing drainage (VSD) lavage were performed initially, with simultaneous uric acid-lowering treatment. A 4x6-8x10 cm sural nerve nutrition flap with peroneal artery perforator was the secondary repair after further debridement of the wound. Preoperative Doppler ultrasound located the penetrating point of the peroneal artery perforator as the rotation point of the flap, and the line between the midpoint of the Achilles' tendon and the lateral malleolus and the midpoint of the popliteal fossa 5 degrees above the front of Achilles' tendon was the axis. The patients were treated postoperatively with anti-inflammatory, anticoagulant and spasmolytic drugs and other rehydration therapy, and allopurinol was continued to control uric acid. The blood supply and temperature of the flap and wound healing were monitored.
   Results: All 7 flaps survived completely after operation, with 1 case of postoperative wound discharge that finally healed after dressing change and 1 case of skin flap redness and swelling, which improved after strengthening anti-infection treatment. All 7 patients were followed up for 6-12 months (average 10 months). The skin flaps were soft in texture, with good color and appearance, and no recurrence of ulceration. The dorsal extension and plantar flexion of the ankle joint were good, and function was satisfactory.
   Conclusions: The sural nerve nutrition flap with peroneal artery perforator has double blood supply, strong anti-infective ability, relatively fast tissue healing process, simple operation and high survival rate, making it ideal for repairing tophus wounds of the heel.
C1 [Zhu, Zhenhua; Zhao, Jiaju; Zuo, Zhicheng; Zhou, Kailong] Soochow Univ, Affiliated Hosp 2, Dept Hand & Foot Surg, Suzhou 215004, Peoples R China.
C3 Soochow University - China
RP Zhou, KL (通讯作者)，Soochow Univ, Affiliated Hosp 2, Dept Hand & Foot Surg, Suzhou 215004, Peoples R China.
EM zhoukailong1982@126.com
RI zhu, zh/KFB-9018-2024
FU Program of Key Research and Development of Jiangsu Province [BE2018656];
   Key Medical Discipline in Suzhou [Szxk201802]; Training Project of
   "National Tutor System" for Young Health Talents in Suzhou; Key
   laboratory of Hand Function reconstruction, Ministry of Health
   [17DZ2270500]
FX This research received financial support from the Program of Key
   Research and Development of Jiangsu Province (grant No. BE2018656), Key
   Medical Discipline in Suzhou (grant No. Szxk201802), Training Project of
   "National Tutor System" for Young Health Talents in Suzhou and the Key
   laboratory of Hand Function reconstruction, Ministry of Health (grant
   No. 17DZ2270500).
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NR 14
TC 3
Z9 5
U1 0
U2 14
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD OCT
PY 2021
VL 10
IS 10
BP 11067
EP 11073
DI 10.21037/apm-21-2809
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA WS1UF
UT WOS:000714973900003
PM 34763468
OA gold
DA 2026-07-24
ER
PT J
AU Liu, ZW
   Zhang, WJ
   Zhang, BY
   Ma, LH
   Zhou, F
   Hu, ZY
   Jie, X
   Gao, H
   Zhu, XH
AF Liu, Zhiwan
   Zhang, Wenjun
   Zhang, Boyu
   Ma, Linhao
   Zhou, Feng
   Hu, Zheyuan
   Jie, Xiang
   Gao, Hong
   Zhu, Xiaohai
TI Toxic shock syndrome complicated with symmetrical peripheral gangrene
   after liposuction and fat transfer: a case report and literature review
SO BMC INFECTIOUS DISEASES
LA English
DT Review
DE Liposuction; Toxic shock syndrome; Multiple organ dysfunction syndrome;
   Necrotizing soft tissue infection; Symmetrical peripheral gangrene
ID STREPTOCOCCUS; MANAGEMENT
AB Background Liposuction is one of the most commonly performed aesthetic procedures. Toxic shock syndrome(TSS) is a rare, life-threatening complication. The incidence rate of TSS is very low in the plastic surgery field, especially after liposuction and fat transfer. Case presentation A 23-year-old female patient was transferred to our emergency department from an aesthetic clinic with sepsis shock features after received liposuction and fat transfer. The patient underwent TSS, disseminated intravascular coagulation(DIC), multiple organ dysfunction syndrome (MODS), symmetrical peripheral gangrene (SPG), and necrotizing soft tissue infection of the buttocks in the next 10 days. Authors used a series of debridement and reconstructive surgery including vacuum sealing drainage (VSD) treatment, artificial dermis grafts,split-thickness skin grafts, amputation surgeries when her vital signs were stable. The patient experienced desquamation of the hand on the 26th day. The skin grafts survived and the function of both fingers and toes recovered. She was discharged 2 months after admission and was in good health. Conclusion TSS is extremely rare in the field of liposuction and autologous fat transfer. The mortality rate of TSS is very high. Early diagnosis and operative treatment, as well as correction of systemic abnormalities, are the important keys to save a patient's life.
C1 [Liu, Zhiwan; Zhang, Wenjun; Hu, Zheyuan; Jie, Xiang; Gao, Hong; Zhu, Xiaohai] Shanghai Changzheng Hosp, Dept Plast Surg, 415 Fengyang Rd, Shanghai 200003, Peoples R China.
   [Zhang, Boyu; Ma, Linhao] Shanghai Changzheng Hosp, Dept Emergency, Shanghai, Peoples R China.
   [Zhou, Feng] Shanghai Tongji Hosp, Dept Plast Surg, Shanghai, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Zhu, XH (通讯作者)，Shanghai Changzheng Hosp, Dept Plast Surg, 415 Fengyang Rd, Shanghai 200003, Peoples R China.
EM drzxh@qq.com
RI zhu, xiaohai/HDO-0462-2022; Jie, Xiang Jie/PQA-2777-2026; Hu,
   Zheyuan/PLR-2482-2026; Ma, Linhao/IUP-2638-2023
OI zhang, wenjun/0000-0001-8264-0754; Ma, Linhao/0000-0001-5846-4308
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NR 40
TC 6
Z9 9
U1 2
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD NOV 6
PY 2021
VL 21
IS 1
AR 1137
DI 10.1186/s12879-021-06777-2
PG 6
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA WS2OK
UT WOS:000715026400001
PM 34742247
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gillespie, BM
   Thalib, L
   Ellwood, D
   Kang, E
   Mahomed, K
   Kumar, S
   Chaboyer, W
AF Gillespie, B. M.
   Thalib, L.
   Ellwood, D.
   Kang, E.
   Mahomed, K.
   Kumar, S.
   Chaboyer, W.
TI Effect of negative-pressure wound therapy on wound complications in
   obese women after caesarean birth: a systematic review and meta-analysis
SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Review
DE Caesarean section; high-risk wound; surgery; surgical site infection;
   vacuum therapy; wound complication; wound dressing
ID SURGICAL-SITE INFECTION; CLOSED INCISION MANAGEMENT; DELIVERY; IMPACT;
   PREVENTION; SURGERY; TRIAL; RISK
AB Background Obesity is associated with increased surgical-site infection (SSI) following caesarean section (CS). Objective To summarise the evidence on the effectiveness of negative-pressure wound therapy (NPWT) for preventing SSI and other wound complications in obese women after CS. Search strategy MEDLINE, Embase, CINAHL, Cochrane CENTRAL databases and were systematically searched in March 2021. Selection criteria Randomised controlled trials (RCTs) of NPWT compared with standard dressings after CS birth. Data collection and analysis Pooled effect sizes were calculated using either fixed or random effects models based on heterogeneity. The Cochrane risk of bias and Grading of Recommendations Assessment, Development and Evaluation tools were used to assess the quality of studies and overall quality of evidence. Main results Ten RCTs with 5583 patients were included; studies were published between 2012 and 2021. Nine RCTs with 5529 patients were pooled for the outcome SSI. Meta-analysis results suggest a significant difference favouring the NPWT group (relative risk [RR] 0.79, 95% CI 0.65-0.95, P < 0.01), indicating an absolute risk reduction of 1.8% among those receiving NPWT compared with usual care. The risk of blistering in the NPWT group was significantly higher (RR 4.13, 95% CI 1.53-11.18, P = 0.005). All studies had high risk of bias relative to blinding of personnel/participants. Only 40% of studies reported blinding of outcome assessments and 50% had incomplete outcome data. Conclusions The decision to use NPWT should be considered both in terms of its potential benefits and its limitations. Tweetable abstract NPWT was associated with fewer SSI in women following CS birth but was not effective in reducing other wound complications.
C1 [Gillespie, B. M.; Chaboyer, W.] Griffith Univ, Natl Hlth & Med Res Council Ctr Res Excellence Wi, Menzies Hlth Inst, Gold Coast, Qld, Australia.
   [Gillespie, B. M.; Chaboyer, W.] Gold Coast Hosp & Hlth Serv, Gold Coast, Qld, Australia.
   [Thalib, L.] Istanbul Aydin Univ, Fac Med, Dept Biostat, Istanbul, Turkey.
   [Ellwood, D.] Griffith Univ, Sch Med & Dent, Gold Coast, Qld, Australia.
   [Ellwood, D.] Gold Coast Univ Hosp, Gold Coast, Qld, Australia.
   [Kang, E.] Griffith Univ, Menzies Hlth Inst, Gold Coast, Qld, Australia.
   [Mahomed, K.] Ipswich Hosp, Ipswich, Qld, Australia.
   [Kumar, S.] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
   [Kumar, S.] Mater Mothers Hosp, South Brisbane, Qld, Australia.
C3 Griffith University; Menzies Health Institute Queensland; Gold Coast
   University Hospital; Istanbul Aydin University; Griffith University;
   Gold Coast University Hospital; Menzies Health Institute Queensland;
   Griffith University; University of Queensland; Mater Research; Mater
   Health Services; Mater Mothers' Hospital
RP Gillespie, BM (通讯作者)，Griffith Univ, NHMRC Wiser Wounds CRE, MHIQ, Gold Coast, Qld 4215, Australia.
EM b.gillespie@griffith.edu.au
RI Mahomed, Kassam/M-1335-2013; Gillespie, Brigid/E-7799-2012; Thalib,
   Lukman/HAI-7553-2022; Ellwood, David/C-8208-2015; Chaboyer,
   Wendy/F-9588-2018
OI Thalib, Lukman/0000-0002-1211-6495; Kang, Evelyn/0000-0001-8253-1638;
   Ellwood, David/0000-0003-4512-6443; Chaboyer, Wendy/0000-0001-9528-7814
CR [Anonymous], 2020, REV MANAGER REVMAN C
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NR 39
TC 10
Z9 12
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1470-0328
EI 1471-0528
J9 BJOG-INT J OBSTET GY
JI BJOG
PD JAN
PY 2022
VL 129
IS 2
BP 196
EP 207
DI 10.1111/1471-0528.16963
EA NOV 2021
PG 12
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA XP8SR
UT WOS:000715865700001
PM 34622545
DA 2026-07-24
ER
PT J
AU Simsek, A
AF Simsek, Arife
TI Thigh Abscess Secondary to Intra-abdominal Pathologic Conditions: Three
   Cases Progressing to Necrotizing Fasciitis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE thigh abscess; necrotizing fasciitis; debridement; intra-abdominal
   pathologic condition; negative pressure wound therapy; enterocutaneous
   fistula
ID RETROPERITONEAL; PERFORATION
AB Introduction. Necrotizing fasciitis results in progressive destruction of the fascia and overlying tissue. Mortality primarily depends upon the timing of medical care and the extent of infection. Objective. This article presents a case series of thigh abscesses originating from intra-abdominal pathologic conditions and progressing to necrotizing fasciitis due to delayed diagnosis. Materials and Methods. The data concerning 3 patients with thigh abscess originating from an intra-abdominal pathologic condition and progressing to necrotizing fasciitis are presented. Results. All patients had undergone previous colorectal surgery for malignancy and were admitted to the hospital with pain concentrated in the lower back and spreading down to the buttock, sacrum and coccyx, and leg. Patients had received symptomatic therapy, including nonsteroidal anti-inflammatory drugs, and 1 patient had undergone diskectomy for a herniated disk in the lumbar region. All 3 patients subsequently developed thigh abscesses (initially treated by percutaneous and/or surgical drainage) and received antibiotic therapy. One patient underwent percutaneous drainage, and 2 patients underwent abdominal surgery to address the abdominal abscess. During the course of treatment, thigh abscesses progressed to necrotizing fasciitis, which was treated by surgical debridement with or without negative pressure wound therapy. All patients died of overwhelming sepsis. Conclusions. Thigh abscess may spontaneously arise from surrounding soft tissues, or it may be a sign of intraperitoneal, retroperitoneal, or pelvic pathologic conditions. Deep, vague pain in the back or hip area that spreads downward to the buttock and leg may be an early symptom of these pathologic conditions. Clinical suspicion may be effective in reducing mortality by enabling early surgical intervention, especially in the patient with a previous history of abdominal surgery, radiotherapy, or inflammatory or malignant disease.
C1 [Simsek, Arife] Inonu Univ, Sch Med, Dept Gen Surg, TR-44100 Malatya, Turkey.
C3 Inonu University
RP Simsek, A (通讯作者)，Inonu Univ, Sch Med, Dept Gen Surg, TR-44100 Malatya, Turkey.
EM draksimsek@yahoo.com.tr
RI Simsek, Arife/AAB-3245-2021
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NR 13
TC 2
Z9 3
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2021
VL 33
IS 9
BP 226
EP 230
DI 10.25270/wnds/2021.226230
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA WT5BS
UT WOS:000715879600002
PM 34734841
DA 2026-07-24
ER
PT J
AU Fernandez, L
   Schar, A
   Matthews, M
   Kim, PJ
   Thompson, C
   Williams, N
   Stutsman, M
AF Fernandez, Luis
   Schar, Adam
   Matthews, Marc
   Kim, Paul J.
   Thompson, Christopher
   Williams, Natalie
   Stutsman, Mandy
TI Synthetic Hybrid-Scale Fiber Matrix in the Trauma and Acute Care
   Surgical Practice
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE synthetic hybrid-scale fiber matrix; negative pressure wound therapy;
   split-thickness skin graft; acute wound
ID OPEN FRACTURES; MANAGEMENT; CALCIPHYLAXIS; CLOSURE
AB Complex cutaneous wounds resulting from disease and trauma can be difficult to heal and may require advanced treatment options. Split-thickness skin grafts (STSGs) and other biologic allogeneic and xenogeneic skin substitutes are limited in their ability to manage these lesions, and STSGs may also be limited in availability. A synthetic hybrid-scale fiber matrix, engineered with an architecture similar to native extracellular matrix, has been shown to have excellent durability and does not carry the risks of disease transmission or inflammatory response associated with biologic materials; it may offer a new option for managing these complex wounds. In this preliminary study, the synthetic matrix was used to treat 3 patients with difficult-to-treat wounds, including lesions associated with calciphylaxis, enteroatmospheric abdominal fistula, and necrotizing fasciitis of the hand with exposed tendon. Treatment with the synthetic matrix resulted in significant reepithelialization and wound healing. The successful results suggest that the synthetic matrix enables healing of complex cutaneous wounds and may be a reasonable alternative to STSG, even in particularly challenging cases.
C1 [Fernandez, Luis; Schar, Adam; Williams, Natalie; Stutsman, Mandy] Univ Texas Tyler, Hlth Sci Ctr, Tyler, TX 75799 USA.
   [Matthews, Marc] Univ Arizona, Coll Med, Tucson, AZ USA.
   [Kim, Paul J.] UT Southwestern, Dallas, TX USA.
   [Thompson, Christopher] UT Hlth East Texas, Tyler, TX USA.
C3 University of Texas System; University of Texas-Health Sciences Center
   at Tyler (UTHSCT); University of Texas at Tyler; University of Arizona;
   University of Texas System; University of Texas Southwestern Medical
   Center
RP Fernandez, L (通讯作者)，Univ Texas Tyler, Hlth Sci Ctr, Dept Surg, Tyler, TX 75799 USA.
EM thebigkahuna115@gmail.com
RI ; FERNANDEZ, LUIS/O-7657-2019
OI , Paul/0000-0002-6186-6890; 
CR Aljasir A, 2018, GMS INTERDISCIP PLAS, V7, DOI 10.3205/iprs000123
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   Killeen AL, 2018, WOUNDS, V30, pE98
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NR 31
TC 18
Z9 20
U1 1
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2021
VL 33
IS 9
BP 237
EP 244
DI 10.25270/wnds/2021.237244
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA WT5BS
UT WOS:000715879600004
PM 34734842
DA 2026-07-24
ER
PT J
AU Fourman, MS
   Ramsey, DC
   Newman, ET
   Schwab, JH
   Chen, YL
   Hung, YP
   Chebib, I
   Deshpande, V
   Nielsen, GP
   DeLaney, TF
   Mullen, JT
   Raskin, KA
   Calderón, SAL
AF Fourman, Mitchell S.
   Ramsey, Duncan C.
   Newman, Erik T.
   Schwab, Joseph H.
   Chen, Yen-Lin
   Hung, Yin P.
   Chebib, Ivan
   Deshpande, Vikram
   Nielsen, G. Petur
   DeLaney, Thomas F.
   Mullen, John T.
   Raskin, Kevin A.
   Calderon, Santiago A. Lozano
TI Assessing the Safety and Utility of Wound VAC Temporization of the
   Sarcoma or Benign Aggressive Tumor Bed Until Final Margins Are Achieved
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Article
ID SOFT-TISSUE SARCOMA; PROGNOSTIC-FACTORS; LOCAL RECURRENCE; THERAPY;
   EXTREMITY; SURVIVAL
AB Background Local recurrence of microinvasive sarcoma or benign aggressive pathologies can be limb- and life-threatening. Although frozen pathology is reliable, tumor microinvasion can be subtle or missed, having an impact on surgical margins and postoperative radiation planning. The authors' service has begun to temporize the tumor bed after primary tumor excision with a wound vacuum-assisted closure (VAC) pending formal margin analysis, with coverage performed in the setting of final negative margins. Methods This retrospective analysis included all patients managed at a tertiary referral cancer center with VAC temporization after soft tissue sarcoma or benign aggressive tumor excision from 1 January 2000 to 1 January 2019 and at least 2 years of oncologic follow-up evaluation. The primary outcome was local recurrence. The secondary outcomes were distant recurrence, unplanned return to the operating room for wound/infectious indications, thromboembolic events, and tumor-related deaths. Results For 62 patients, VAC temporization was performed. The mean age of the patients was 62.2 +/- 22.3 years (median 66.5 years; 95% confidence interval [CI] 61.7-72.5 years), and the mean age-adjusted Charlson Comorbidity Index was 5.3 +/- 1.9. The most common tumor histology was myxofibrosarcoma (51.6%, 32/62). The mean volume was 124.8 +/- 324.1 cm(3), and 35.5% (22/62) of the cases were subfascial. Local recurrences occurred for 8.1% (5/62) of the patients. Three of these five patients had planned positive margins, and 17.7% (11/62) of the patients had an unplanned return to the operating room. No demographic or tumor factors were associated with unplanned surgery. Conclusions The findings showed that VAC-temporized management of microinvasive sarcoma and benign aggressive pathologies yields favorable local recurrence and unplanned operating room rates suggestive of oncologic and technical safety. These findings will need validation in a future randomized controlled trial.
C1 [Fourman, Mitchell S.; Ramsey, Duncan C.; Newman, Erik T.; Raskin, Kevin A.; Calderon, Santiago A. Lozano] Massachusetts Gen Hosp, Dept Orthopaed Surg, Orthopaed Oncol Serv, Boston, MA 02114 USA.
   [Schwab, Joseph H.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Spine Serv, Boston, MA 02114 USA.
   [Chen, Yen-Lin; DeLaney, Thomas F.] Massachusetts Gen Hosp Canc Ctr, Dept Radiat Oncol, Boston, MA USA.
   [Hung, Yin P.; Chebib, Ivan; Deshpande, Vikram; Nielsen, G. Petur] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA.
   [Mullen, John T.] Massachusetts Gen Hosp, Dept Surg, Surg Oncol Serv, Boston, MA 02114 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital
RP Calderón, SAL (通讯作者)，Massachusetts Gen Hosp, Dept Orthopaed Surg, Orthopaed Oncol Serv, Boston, MA 02114 USA.
EM slozanocalderon@mgh.harvard.edu
RI ; Fourman, Mitchell/GXF-4477-2022; Ramsey, Duncan/GVU-7429-2022; Hung,
   Yin Pun/AAV-4868-2021; Deshpande, Vikram/AEN-2602-2022
OI Schwab, Joseph/0000-0002-2059-7559; Fourman,
   Mitchell/0000-0001-5886-546X; Ramsey, Duncan/0000-0003-2058-9556; Hung,
   Yin Pun/0000-0002-8568-1591; HUITRON, EFREN/0009-0008-2046-3359
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NR 31
TC 12
Z9 13
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1068-9265
EI 1534-4681
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD APR
PY 2022
VL 29
IS 4
BP 2290
EP 2298
DI 10.1245/s10434-021-11023-9
EA NOV 2021
PG 9
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA ZV7LQ
UT WOS:000716290400003
PM 34751874
DA 2026-07-24
ER
PT J
AU Chen, L
   Zhang, S
   Da, J
   Wu, WC
   Ma, F
   Tang, C
   Li, GZ
   Zhong, DJ
   Liao, B
AF Chen, Lin
   Zhang, Shuang
   Da, Jun
   Wu, Wencong
   Ma, Fei
   Tang, Chao
   Li, Guangzhou
   Zhong, Dejun
   Liao, Bin
TI A systematic review and meta-analysis of efficacy and safety of negative
   pressure wound therapy in the treatment of diabetic foot ulcer
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Review
DE Negative pressure wound therapy; diabetic foot (DF); ulcer; safety;
   meta-analysis
ID VACUUM-ASSISTED CLOSURE; MULTICENTER
AB Background: Negative pressure wound therapy (NPWT) is one of the new modality for the treatment of diabetic foot ulcers. In this article we will investigate the efficacy and safety of it by literature search and meta-analysis.
   Methods: The databases of PubMed, Embase, Ovid, and Cochrane library were selected as search platforms. Randomized controlled trials (RCTs) published after 2010 were searched with the keyword "vacuum-assisted closure therapy" OR "negative pressure wound therapy" OR "diabetic foot". The Cochrane Review Handbook was used to assess the bias of the literatures. The software RevMan 5.4 was used for analysis to obtain a forest plot and funnel plot.
   Results: In this study, 363 articles were initially screened, and 9 literatures were finally included, involving a total of 943 patients. Combined analysis using the fixed effects model showed that the healing rate of the NPWT group was significantly lower than the standard group [odds ratio (OR) = 3.60, 95% confidence interval (CI): 2.38 to 5.45, P<0.001]. The granulation tissue formation time of the NPWT group was significantly less than the standard group [mean difference (MD) = -8.95, 95% CI: -10.26 to -7.64, P<0.001]. The rate of adverse events of both groups showed no significant difference (OR = 0.49, 95% CI: 0.10 to 2.42, P=0.38). The amputation rate of both groups showed no statistically significant (OR = 0.33, 95% CI: 0.09 to 1.26, P=0.10) too.
   Discussion: Negative pressure wound therapy can effectively accelerate wound healing, it is equally safe with general routine treatment. However, the negative pressure value should be appropriately maintained and adjusted to avoid bleeding tendency of the wound when applying this new modality.
C1 [Chen, Lin; Zhang, Shuang; Da, Jun; Wu, Wencong; Ma, Fei; Tang, Chao; Li, Guangzhou; Zhong, Dejun] Southwest Med Univ, Dept Orthoped, Affiliated Hosp, Luzhou, Peoples R China.
   [Liao, Bin] Southwest Med Univ, Dept Supply Room, Affiliated Hosp, 25 Taiping St, Luzhou 646000, Peoples R China.
C3 Southwest Medical University; Southwest Medical University
RP Liao, B (通讯作者)，Southwest Med Univ, Dept Supply Room, Affiliated Hosp, 25 Taiping St, Luzhou 646000, Peoples R China.
EM liaobin0808789@163.com
CR [Anonymous], 2006, Cochrane Handbook for Systematic Reviews of Interventions
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NR 23
TC 57
Z9 73
U1 5
U2 29
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD OCT
PY 2021
VL 10
IS 10
BP 10830
EP 10839
DI 10.21037/apm-21-2476
PG 10
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA WW0KP
UT WOS:000717616300006
PM 34763444
OA gold
DA 2026-07-24
ER
PT J
AU Liu, L
   Chen, RF
   Jia, ZG
   Li, XT
   Tang, Y
   Zhao, XT
   Zhang, SQ
   Luo, L
   Fang, ZH
   Zhang, YZ
   Chen, MW
AF Liu, Lei
   Chen, Ruofei
   Jia, Zeguo
   Li, Xueting
   Tang, Ying
   Zhao, Xiaotong
   Zhang, Shiqi
   Luo, Li
   Fang, Zhaohui
   Zhang, Yuanzhi
   Chen, Mingwei
TI Downregulation of hsa-miR-203 in peripheral blood and wound margin
   tissue by negative pressure wound therapy contributes to wound healing
   of diabetic foot ulcers
SO MICROVASCULAR RESEARCH
LA English
DT Article
DE Type 2 diabetes; Foot ulcers; Negative pressure wound therapy;
   Keratinocytes; Hsa-miR-203; p63
ID VACUUM-ASSISTED CLOSURE; EXPRESSION; SKIN; MICRORNA-203;
   DIFFERENTIATION; MANAGEMENT; UPDATE; SERUM
AB Negative pressure wound therapy (NPWT) has been widely used in the treatment of chronic wounds, including diabetic foot ulcers (DFU) as the severe manifestation of diabetic foot. Hsa-miR-203 is proven to be correlated with the severity of DFU. To investigate whether NPWT influences hsa-miR-203 levels in persons with DFU, we detected hsa-miR-203 levels in peripheral plasma and wound margin tissue from the following patients: type 2 diabetic (T2D) patients with DFU (DFU group), T2D patients without DFU (NDFU group), patients with chronic skin ulcer and normal glucose tolerance (SUC group), and healthy volunteers with normal glucose tolerance (NC group). All patients in SUC group received NPWT. As contrast, some of patients in DFU group received NPWT (NPWT group) while others chose routine dressing therapy (non-NPWT group). In vitro experiments were also performed to determine influences of negative pressure on cell proliferation and migration of HaCaT cells (human keratinocytes). Results showed that before NPWT, levels of hsa-miR-203 in peripheral plasma (P-miR203) and wound margin tissue (T-miR-203) of DFU group were obviously increased compared to SUC group while expression of P-miR-203 decreased in NDFU group compared with NC group. After NPWT, levels of P-miR203 and T-miR-203 in DFU and SUC group were significantly lower than before. Changes of P-miR-203 and TmiR-203 after NPWT were positively correlated with 4-week ulcer healing rate in NPWT and SUC group. In vitro, negative pressure lowered the expression of hsa-miR-203, enhancing cell proliferation and migration in HaCaT cells via up-regulation of p63 protein. Meanwhile, the effects of negative pressure on cells were remarkable reduced by high-glucose intervention. Our study suggests that NPWT promotes DFU healing by reducing the expression of hsa-miR-203 in peripheral blood and wound tissue. The changes of hsa-miR-203 in peripheral blood and wound tissue may be related to the therapeutic effect of NPWT.
C1 [Liu, Lei; Jia, Zeguo; Li, Xueting; Tang, Ying; Zhao, Xiaotong; Zhang, Shiqi; Luo, Li; Chen, Mingwei] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd,Shushan Dist, Hefei 230022, Peoples R China.
   [Chen, Ruofei] Anhui Med Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Hefei 230022, Peoples R China.
   [Fang, Zhaohui; Chen, Mingwei] Anhui Univ Chinese Med, Affiliated Hosp 1, Dept Endocrinol, Hefei 230031, Peoples R China.
   [Zhang, Yuanzhi] Chinese Acad Sci, Hefei Inst Phys Sci, Beijing, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui University of
   Chinese Medicine; Chinese Academy of Sciences; Hefei Institutes of
   Physical Science, CAS
RP Chen, MW (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd,Shushan Dist, Hefei 230022, Peoples R China.; Chen, MW (通讯作者)，Anhui Univ Chinese Med, Affiliated Hosp 1, Dept Endocrinol, Hefei 230031, Peoples R China.
EM chmw1@163.com
RI CHEN, MINGWEI/KHT-6744-2024
OI Liu, Lei/0000-0002-4725-7941
FU Key Research and Development Program of Anhui Province
   [202004a07020016]; Natural Science Foundation of Anhui Province
   [2108085MH269]
FX This study was supported by grants from the Key Research and Development
   Program of Anhui Province (Grant No. 202004a07020016) and the Natural
   Science Foundation of Anhui Province (Grant No. 2108085MH269).
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NR 44
TC 15
Z9 15
U1 0
U2 25
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0026-2862
EI 1095-9319
J9 MICROVASC RES
JI Microvasc. Res.
PD JAN
PY 2022
VL 139
AR 104275
DI 10.1016/j.mvr.2021.104275
EA NOV 2021
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA WW3XD
UT WOS:000717852800004
PM 34717969
DA 2026-07-24
ER
PT J
AU Kaczmarek, DJ
   Heling, DJ
   Gonzalez-Carmona, MA
   Strassburg, CP
   Branchi, V
   Matthaei, H
   Kalff, J
   Manekeller, S
   Glowka, TR
   Weismüller, TJ
AF Kaczmarek, Dominik J.
   Heling, Dominik J.
   Gonzalez-Carmona, Maria A.
   Strassburg, Christian P.
   Branchi, Vittorio
   Matthaei, Hanno
   Kalff, Joerg
   Manekeller, Steffen
   Glowka, Tim R.
   Weismueller, Tobias J.
TI Management of post-operative pancreatic fistulas following
   Longmire-Traverso pylorus-preserving pancreatoduodenectomy by endoscopic
   vacuum-assisted closure therapy
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Endo-sponge; Endoscopic vacuum-assisted wound closure system;
   Anastomotic leakage; Pancreaticogastric anastomotic insufficiency;
   Pancreaticogastrostomy
ID FLUID COLLECTIONS; PANCREATICOJEJUNOSTOMY; PANCREATICOGASTROSTOMY;
   RECONSTRUCTION; DRAINAGE; ESOPHAGEAL; LEAKAGE; RISK;
   PANCREATOGASTROSTOMY; PANCREATOJEJUNOSTOMY
AB Background Pylorus-preserving pancreatoduodenectomy (PPPD) with pancreatogastrostomy is a standard surgical procedure for pancreatic head tumors, duodenal tumors and distal cholangiocarcinomas. Post-operative pancreatic fistulas (POPF) are a major complication causing relevant morbidity and mortality. Endoscopic vacuum therapy (EVT) has become a widely used method for the treatment of intestinal perforations and leakages. Here we report on a pilot single center series of 8 POPF cases specifically caused by dehiscences of the pancreatogastric anastomosis (PGD), successfully managed by EVT. Methods We included all patients with PGD after PPPD, who were treated with EVT between 07/2017 and 08/2020. For EVT a vacuum drainage film (EVT film) or open-pore polyurethane foam sponge (EVT sponge) was fixed to a 14Fr or 16Fr suction catheter and placed endoscopically within the PGD for intracavitary EVT with continuous suction between - 100 and - 150 mmHg. The EVT film/sponge was exchanged twice per week. EVT was discontinued when the PGD was sufficiently healed. Results PGD closure was achieved in 7 of 8 patients after a mean EVT time of 16 days (range 8-38) and 3 EVT film/sponge exchanges (range 1-9). One patient died on day 18 after PPPD from acute hemorrhagic shock, unlikely related to EVT, before effectiveness of EVT could be fully achieved. There were no adverse events directly attributable to EVT. Conclusions EVT could be an effective and safe addition to our therapeutic armamentarium in the management of POPF with PGD. Unless prospective comparative studies are available, EVT as minimally invasive therapeutic alternative should be considered individually by an interdisciplinary team involving endoscopists, surgeons and radiologists.
C1 [Kaczmarek, Dominik J.; Heling, Dominik J.; Gonzalez-Carmona, Maria A.; Strassburg, Christian P.; Weismueller, Tobias J.] Univ Bonn, Dept Internal Med 1, Bonn, Germany.
   [Branchi, Vittorio; Matthaei, Hanno; Kalff, Joerg; Manekeller, Steffen; Glowka, Tim R.] Univ Bonn, Dept Gen Visceral Thorac & Vasc Surg, Bonn, Germany.
   [Weismueller, Tobias J.] Vivantes Humboldt Hosp, Dept Internal Med Gastroenterol & Oncol, Nordgraben 2, D-13509 Berlin, Germany.
C3 University of Bonn; University of Bonn; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin
RP Weismüller, TJ (通讯作者)，Univ Bonn, Dept Internal Med 1, Bonn, Germany.; Weismüller, TJ (通讯作者)，Vivantes Humboldt Hosp, Dept Internal Med Gastroenterol & Oncol, Nordgraben 2, D-13509 Berlin, Germany.
EM Tobias.Weismueller@gmx.de
RI Weismüller, Tobias J/I-1879-2019; Glowka, Tim R/AAW-6804-2021; Kalff,
   Joerg/U-8580-2017
OI Weismüller, Tobias J/0000-0001-9736-1483; Glowka, Tim
   R/0000-0001-6996-9766; 
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 46
TC 11
Z9 11
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD NOV 12
PY 2021
VL 21
IS 1
AR 425
DI 10.1186/s12876-021-02000-3
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA WW5VC
UT WOS:000717982900003
PM 34772366
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Huang, QQ
   Huang, K
   Xue, JJ
AF Huang, Qianqian
   Huang, Kai
   Xue, Jinjun
TI Vacuum sealing drainage combined with free anterolateral femoral skin
   flap grafting in 16 cases of pediatric soft tissue damage to the foot
   and ankle
SO TRANSLATIONAL PEDIATRICS
LA English
DT Article
DE Vacuum sealing drainage (VSD); anterolateral femoral flap grafting;
   pediatric; soft tissue trauma
ID ARTERY PERFORATOR FLAP; REPAIR
AB Background: To investigate the clinical experience and discuss the use of vacuum sealing drainage (VSD) combined with free anterolateral femoral flap grafting to treat pediatric foot and ankle soft tissue traumas.
   Methods: This was a retrospective analysis of 16 pediatric patients with foot and ankle soft tissue traumas treated with free anterolateral femoral flap grafting from January 2015 to January 2018. After successful debridement and VSD, the clinical efficacy of the procedure was evaluated by observing parameters such as the color, shape, and texture of the flap on the receptor site.
   Results: All patients were followed up for 23-32 months after surgery. Of the 16 patients, six had a flat flap appearance, while the remaining ten patients required flap repair surgery 6-9 months after the procedure. Eight of these ten patients had a satisfactory repair, and the remaining two patients had further repair surgery 9-10 months after the flap grafting. The postoperative results of all patients were satisfactory; no local infection, good flap survival, soft texture, glossy elasticity, and flat appearance. Statistical results showed only one case of local necrosis at the distal end of the flap, and the wound healed at stage II after redebridement and dressing change.
   Conclusions: VSD combined with free anterolateral femoral flap grafting is an easy and reliable operation with a good prognosis and excellent clinical utility and feasibility for treating pediatric patients with foot and ankle soft tissue traumas.
C1 [Huang, Qianqian] Tongde Hosp Zhejiang Prov, Operating Theatre, Hangzhou, Peoples R China.
   [Huang, Kai] Tongde Hosp Zhejiang Prov, Dept Orthoped, Hangzhou, Peoples R China.
   [Xue, Jinjun] Tongde Hosp Zhejiang Prov, Dept Pediat, 234 Gucui Rd, Hangzhou 310012, Peoples R China.
C3 Tongde Hospital of Zhejiang Province; Tongde Hospital of Zhejiang
   Province; Tongde Hospital of Zhejiang Province
RP Xue, JJ (通讯作者)，Tongde Hosp Zhejiang Prov, Dept Pediat, 234 Gucui Rd, Hangzhou 310012, Peoples R China.
EM xuejinjunzjtd@163.com
RI 黄, 恺/AAO-1485-2021
FU Zhejiang Province Public Welfare Technology Application Research Project
   [LGF21H270004]; Natural Science Foundation of Zhejiang Province
   [LY20H270002]; Medical Science and Technology Project of Zhejiang
   Province [2020RC048, 2021KY600]; Chinese Medicine Research Program of
   Zhejiang Province [2020ZQ006, 2021ZB060]
FX This study was funded by the Zhejiang Province Public Welfare Technology
   Application Research Project (LGF21H270004) , the Natural Science
   Foundation of Zhejiang Province (LY20H270002) , the Medical Science and
   Technology Project of Zhejiang Province (2020RC048, 2021KY600) , and the
   Chinese Medicine Research Program of Zhejiang Province (2020ZQ006,
   2021ZB060) . The funders had no role in the study design, data
   collection and analysis, decision to publish, or manuscript preparation.
CR Bergmann M, 2021, PEDIATR CARDIOL, V42, P78, DOI 10.1007/s00246-020-02456-2
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   Sue GR, 2020, MICROSURG, V40, P427, DOI 10.1002/micr.30543
   Sui XL, 2019, J PLAST RECONSTR AES, V72, P1494, DOI 10.1016/j.bjps.2019.05.026
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   Xu ZF, 2015, J ORAL MAXIL SURG, V73, DOI 10.1016/j.joms.2015.08.010
   Zocchi ML, 2021, EUR J PLAST SURG, V44, P389, DOI 10.1007/s00238-021-01812-6
NR 16
TC 14
Z9 18
U1 0
U2 4
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-4336
EI 2224-4344
J9 TRANSL PEDIATR
JI Transl. Pediatr.
PD OCT
PY 2021
VL 10
IS 10
BP 2489
EP 2495
DI 10.21037/tp-21-399
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA WX0NO
UT WOS:000718302100009
PM 34765472
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rauch-Pucher, M
   McCartney, T
   Cox-Reber, J
   Markwell, A
AF Rauch-Pucher, Mackenzie
   McCartney, Teresa
   Cox-Reber, Jessica
   Markwell, Ashley
TI Abdominal Soft Tissue Infection Caused by Mycobacterium wolinskyi
   After Cosmetic Surgery A Case Report
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Mycobacterium wolinskyi; Negative pressure wound therapy; Wound care
   nurse
AB BACKGROUND: Mycobacterium wolinskyi is a rare, fast-growing, painful bacterium causing soft tissue infections. Sparse case reports focus on long-term intravenous antibiotic therapy and surgical interventions. We searched the literature and found almost no discussion about treatment from a nursing and wound care perspective. CASE: Ms P, a 30-year-old Arabic female patient, underwent cosmetic surgery in Iraq including liposuction, abdominoplasty, and herniorrhaphy. One month postoperatively, she presented with an infection identified as M. wolinskyi resulting in multiple hospital admissions. Ms P received treatment with long-term antibiotic therapy and underwent multiple surgical debridements with extensive wound care management. CONCLUSION: Mycobacterium wolinskyi is an exceedingly rare bacterium not typically seen in the clinical setting and requires prolonged and aggressive treatment. It is painful and fast-growing, as evidenced by multiple abscess formations and tissue necrosis in this case. Daily assessments and wound management using a collaborative approach were important to promote optimal healing.
C1 [Rauch-Pucher, Mackenzie; McCartney, Teresa; Cox-Reber, Jessica; Markwell, Ashley] Beaumont Hosp, 18101 Oakwood Blvd, Dearborn, MI 48124 USA.
C3 Beaumont Health
RP Markwell, A (通讯作者)，Beaumont Hosp, 18101 Oakwood Blvd, Dearborn, MI 48124 USA.
EM Ashley.stoeckle@beaumont.org
CR Bhatnagar Nishit, 2019, JBJS Case Connect, V9, pe0315, DOI [10.2106/jbjs.cc.18.00315, 10.2106/JBJS.CC.18.00315]
   Bossart S, 2016, CASE REP DERMATOL, V8, P151, DOI 10.1159/000446470
   Chouliara Z., 2020, Dermatol Nurs, V19, P36
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   Kitajima H, 2021, J INFECT CHEMOTHER, V27, P766, DOI 10.1016/j.jiac.2020.12.019
   Krasner DL., 2016, Acute & Chronic Wounds: Current Management Concepts, P386
   Lalezari S, 2017, INT WOUND J, V14, P649, DOI 10.1111/iwj.12658
   Lima AS, 2013, INFECT DIS REP, V5, P40, DOI 10.4081/idr.2013.e12
   Panayi AC, 2017, World Journal of Dermatology, V6, P1, DOI [10.5314/wjd.v6.i1.1, 10.5314/wjd.v6.i1.1, DOI 10.5314/WJD.V6.I1.1]
   Saim S., 2016, Acute & Chronic Wounds: Current Management Concepts, P325
   Yoo SJ, 2013, BMC INFECT DIS, V13, DOI 10.1186/1471-2334-13-479
NR 12
TC 2
Z9 4
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD NOV-DEC
PY 2021
VL 48
IS 6
BP 573
EP 577
DI 10.1097/WON.0000000000000826
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA WX4AB
UT WOS:000718539500015
PM 34781315
DA 2026-07-24
ER
PT J
AU Tekin, EE
   Yesiltas, MA
   Uysal, A
   Haberal, I
AF Tekin, Esra Erturk
   Yesiltas, Mehmet Ali
   Uysal, Ayhan
   Haberal, Ismail
TI The effectiveness of vacuum-assisted closure therapy in patients with
   infected venous leg ulcers
SO CARDIOVASCULAR JOURNAL OF AFRICA
LA English
DT Article
DE vacuum-assisted closure therapy; venous ulcer; post-thrombotic syndrome;
   wound infection; rapid wound healing
ID MANAGEMENT; MICROBIOLOGY; PREVALENCE; POPULATION; SOCIETY; TRIAL
AB Aim: In this study, we aimed to investigate the effect of vacu-um-assisted closure therapy on venous stasis wound healing in patients with chronic venous leg ulcers. Methods: Vacuum-assisted closure therapy was applied on a total of 14 venous leg ulcers. All patients had post-thrombotic syndrome. Quantitative wound culture samples were obtained before the procedure and local wound assessments were performed. The primary outcome measures included wound healing as assessed by a local wound examination during each dressing change and the rate and velocity of ulcer reduc-tion. Wound healing was defined as the complete closure of the ulcer, while rapid wound healing was defined as a >= 30% reduction in the ulcer size by week four. Results: No surgical debridement or surgical corrective procedure was applied in any patient. The mean length of hospital stay was 32.3 days. The mean number of vacuum-assisted closure therapies for each case was 17.8 and the mean time to dressing change was 72.3 hours. Multidrug-resistant Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus were detected in three and four patients, respectively. Wound culture results became negative after a mean duration of vacuum-assisted closure therapy of 12.1 days. None of the patients needed antibiotic therapy until the procedure was completed. Compared to baseline, the mean ulcer reduction rates were 46.4% for the first six applications and 72.8% for the subsequent applications. Conclusion: Our study results suggest that vacuum-assisted closure therapy promotes rapid wound healing in patients with severe post-thrombotic syndrome with venous stasis leg ulcers, and reduces the need for antibiotics by reducing the biological burden.
C1 [Tekin, Esra Erturk] Mersin City Training & Res Hosp, Dept Cardiovasc Surg, Mersin, Turkey.
   [Yesiltas, Mehmet Ali] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Cardiovasc Surg, Istanbul, Turkey.
   [Uysal, Ayhan] Firat Univ, Cardiovasc Surg Clin, Med Fac, Elazig, Turkey.
   [Haberal, Ismail] Istanbul Univ, Dept Cardiovasc Surg, Cerrahpasa Inst Cardiol, Istanbul, Turkey.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital; Firat University;
   Istanbul University
RP Tekin, EE (通讯作者)，Mersin City Training & Res Hosp, Dept Cardiovasc Surg, Mersin, Turkey.
EM dresraer@yahoo.com
RI /D-8323-2019; erturk tekin, esra/AFI-8190-2022; /W-5118-2018; YESILTAS,
   Mehmet Ali/D-8568-2019
OI YESILTAS, Mehmet Ali/0000-0002-5208-0626
CR Alavi A, 2016, J AM ACAD DERMATOL, V74, P627, DOI 10.1016/j.jaad.2014.10.048
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NR 44
TC 4
Z9 5
U1 0
U2 4
PU CLINICS CARDIVE PUBL PTY LTD
PI DURBANVILLE
PA PO BOX 1013, DURBANVILLE, 7551, SOUTH AFRICA
SN 1995-1892
EI 1680-0745
J9 CARDIOVASC J AFR
JI Cardiovasc. J. Afr.
PD MAR-APR
PY 2022
VL 33
IS 2
BP 44
EP 50
DI 10.5830/CVJA-2021-034
EA JUL 2021
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1S3IG
UT WOS:000720104000001
PM 34309617
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Qiu, XG
   Wu, YF
   Zhang, D
   Zhang, H
   Yu, AX
   Li, ZH
AF Qiu, Xingan
   Wu, Yifan
   Zhang, Dong
   Zhang, Hao
   Yu, Aixi
   Li, Zonghuan
TI Roles of Oxidative Stress and Raftlin in Wound Healing Under
   Negative-Pressure Wound Therapy
SO CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
LA English
DT Article
DE SOD; CAT; MDA; Raftlin; negative-pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; LIPID RAFT; PROTEIN; COMPLICATIONS;
   INFLAMMATION; INJURIES; BURDEN; OXYGEN
AB Background: Negative-pressure wound therapy (NPWT) is an effective way to promote wound healing. However, its mechanisms have not been investigated thoroughly. Growing evidence suggests that oxidative stress and Raftlin levels play important roles in wound healing. However, whether NPWT promotes wound healing through this mechanism remains unclear.
   Purpose: Our study focuses on the different levels of oxidative stress and antioxidant response between wounds treated by NPWT and routine dressing change. The objective of this study was to measure the differences in Raftlin levels between the two groups, which is a new biomarker related to wound healing.
   Methods: We divided 48 male Sprague-Dawley rats with identical full-thickness skin defects into two groups. At specific times (0, 3, 5, 7, 9, 11, and 13 days after surgery), wound tissue samples were obtained for immunohistochemistry and biochemical analysis. The expression of Raftlin and levels of oxidative stress, including malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels were measured by biochemical analysis. Wound-healing times were also compared.
   Results: In the NPWT group, MDA levels were significantly decreased on days 3, 5, and 7. Furthermore, the expressions of SOD and CAT were significantly reduced on days 3 and 5. Our data also revealed that Raftlin was significantly upregulated across the whole period of wound healing. Moreover, wound healing in the NPWT group was significantly more rapid (16 days on average) than in the control group (24 days on average). On day 13 post surgery, the wound-healing percentage in the NPWT group was 91%, while that in the control group was 48%.
   Conclusion: NPWT may promote wound healing by upregulating Raftlin and inhibiting oxidative stress levels.
C1 [Qiu, Xingan; Wu, Yifan; Zhang, Dong; Zhang, Hao; Yu, Aixi; Li, Zonghuan] Wuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Yu, AX; Li, ZH (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430071, Hubei, Peoples R China.
EM yuaixi@whu.edu.cn; lizonghuan@whu.edu.cn
FU Second Medical Leading Talents Project of Hubei Province [LJ20200405]
FX Y This study was supported by the Second Medical Leading Talents Project
   of Hubei Province (grant no. LJ20200405) .
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NR 42
TC 17
Z9 17
U1 0
U2 14
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7015
J9 CLIN COSMET INV DERM
JI CLIN. COSMET. INVESTIG. DERMATOL.
PY 2021
VL 14
BP 1745
EP 1753
DI 10.2147/CCID.S334248
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA XB5KX
UT WOS:000721369200003
PM 34848985
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mehdorn, M
   Jansen-Winkeln, B
AF Mehdorn, Matthias
   Jansen-Winkeln, Boris
TI Modified Incisional Negative Pressure Wound Therapy Increases Seroma
   Evacuation: An Ex Vivo Model
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID SURGICAL SITE INFECTION; VENTRAL HERNIA REPAIR; MANAGEMENT;
   COMPLICATIONS; SURGERY; LAPAROTOMY
AB Background. Incisional negative wound pressure therapy (iNPWT) is a relatively novel dressing technique with the aim of reducing postoperative wound infections and dehiscence in high-risk wounds after all kinds of surgical procedures. There is a lack of theoretical knowledge about the way those dressing would ameliorate wound healing. One aspect is the reduction of superficial tension, but significant remaining seroma might still cause deep wound infections. The aim of this study was the evaluation of technical modifications of the standard iNPWT dressing to increase seroma evacuation. Methods. iNPWT dressings were applied on the porcine abdominal wall, and an incremental pressure ramp from 50 to 200 mmHg was performed. The resulting wound pressures were measured using (i) balloon manometry and (ii) esophageal manometry catheter. Seroma evacuation was analyzed with a seroma model. All measurements were performed with (i) standard iNPWT dressing, (ii) wound gauze diverted through the incision, and (iii) placement of suction drain tube into iNPWT. Results. Due to the modifications of the iNPWT dressing, the vacuum applied by the iNPWT dressing could be transferred into the wound and was not only restricted to superficial layers. More importantly, placement of wound gauzes or suction drain tubes led to complete extraction of wound seroma. The placement of the suction drain tube showed the best combination of increased intrawound pressure as well as seroma evacuation. Conclusion. Addition of a suction drain tube to the iNPWT dressing leads to an improved function of the iNPWT dressing in our ex vivo model.
C1 [Mehdorn, Matthias; Jansen-Winkeln, Boris] Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, D-04103 Leipzig, Germany.
C3 Leipzig University
RP Mehdorn, M (通讯作者)，Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, D-04103 Leipzig, Germany.
EM matthias.mehdorn@medizin.uni-leipzig.de
RI Jansen-Winkeln, Boris/KPA-5791-2024
OI Jansen-Winkeln, Boris/0000-0002-3996-9391
CR Anker AM, 2021, HANDCHIR MIKROCHIR P, V53, P420, DOI 10.1055/a-1170-5345
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NR 31
TC 5
Z9 5
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD OCT 21
PY 2021
VL 2021
AR 5846724
DI 10.1155/2021/5846724
PG 7
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA XB7JS
UT WOS:000721502300002
PM 34722767
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Pagotto, VPF
   Gallafrio, ST
   Carneiro, IC
   Gemperli, R
   Jatene, FB
AF Figueiredo Pagotto, Vitor Penteado
   Terra Gallafrio, Samuel
   Castro Carneiro, Igor
   Gemperli, Rolf
   Jatene, Fabio B.
TI Treatment and Chest Reconstruction for Mediastinitis Following
   Sternotomy for Cardiac Surgery at the Heart Institute of the University
   of Sao Paulo Medical School
SO BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE Mediastinitis; Negative-Pressure Wound Therapy; Debridement; &nbsp;
   Sternum; Surgical Flaps; Cardiac Surgical Procedures; &nbsp; Infection
   Control
ID MANAGEMENT
AB This study presents the method used for chest reconstruction and treatment of mediastinitis following cardiac surgery at the Heart Institute of the University of Sao Paulo Medical School. After infection control with antibiotic therapy associated with aggressive surgical debridement and negative pressure wound therapy, chest reconstruction is performed using flaps. The advantages and disadvantages of negative pressure wound therapy are discussed, as well as options for flap-based chest reconstruction according to the characteristics of the patient and sternum. Further studies are needed to provide evidence to support the decisions when facing this great challenge.
C1 [Figueiredo Pagotto, Vitor Penteado; Terra Gallafrio, Samuel; Castro Carneiro, Igor; Gemperli, Rolf] Univ Sao Paulo, Div Plast Surg, Ave Dr Eneas Carvalho de Aguiar 255, BR-05403000 Sao Paulo, SP, Brazil.
   [Jatene, Fabio B.] Univ Sao Paulo, Cardiothorac Surg Dept, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Pagotto, VPF (通讯作者)，Univ Sao Paulo, Div Plast Surg, Ave Dr Eneas Carvalho de Aguiar 255, BR-05403000 Sao Paulo, SP, Brazil.
EM vitorpfpagotto@gmail.com
RI Gemperli, Rolf/C-9116-2012; Biscegli Jatene, Fabio/D-1679-2012; Penteado
   Figueiredo Pagotto, Vitor/AEO-9391-2022
OI Biscegli Jatene, Fabio/0000-0001-6175-5595; Penteado Figueiredo Pagotto,
   Vitor/0000-0002-5674-9462
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NR 10
TC 3
Z9 3
U1 0
U2 0
PU SOC BRASIL CIRURGIA CARDIOVASC
PI SAO PAULO SP
PA RUA AFONSO CELSO, 1178, SAO PAULO SP, 04119-061, BRAZIL
SN 0102-7638
EI 1678-9741
J9 BRAZ J CARDIOV SURG
JI Braz. J. Cardiovasc. Surg.
PY 2021
VL 36
IS 4
BP 565
EP 570
DI 10.21470/1678-9741-2020-0117
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA XC0HV
UT WOS:000721701200018
PM 33577255
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Sun, T
   Ying, WJ
   Wang, SS
   Chen, CQ
   Sun, PY
   Tan, JL
AF Sun, Tao
   Ying, Wenjie
   Wang, Shuangshuang
   Chen, Caiqiang
   Sun, Pengyu
   Tan, Jinglei
TI Clinical Application of Vacuum Sealing Drainage for the Treatment of
   Deep Burn Wounds
SO AMERICAN SURGEON
LA English
DT Article
DE vacuum sealing drainage; burn; deep burn; wound recovery; clinical
   effect
ID DIABETIC FOOT ULCERS; THERAPY; MANAGEMENT; TISSUE; DEBRIDEMENT;
   INFECTION
AB Background This study aimed to determine the effect of the clinical application of vacuum sealing drainage (VSD) on the treatment of deep burn wounds. Methods This single-blind, randomized, controlled study included patients who were admitted to our hospital with deep burns from January 2018 to December 2020; the patients were randomly divided into the VSD and control (CON) groups. The number of days from treatment to skin grafting; survival rate of the first skin graft; rate of positive bacterial culture; visual analog scale (VAS) pain score; and durations of wound healing, antibiotic drug use, and hospitalization were analyzed and compared between the groups. Results The application of VSD significantly shortened the number of days from treatment to skin grafting (P < .05); improved the survival rate of the first skin graft in patients with severe burns (P < .05); reduced the rate of positive bacterial culture (P < .05); reduced the VAS pain score (P < .05); and shortened the durations of wound healing (P < .05), antibiotic drug use (P < .05), and hospitalization (P < .05). Conclusion Vacuum sealing drainage had a good clinical effect on the recovery of deep burn wounds.
C1 [Sun, Tao; Ying, Wenjie; Wang, Shuangshuang; Chen, Caiqiang; Sun, Pengyu; Tan, Jinglei] First Peoples Hosp Wenling, Dept Burns & Plast Surg, 333 Chuanan South Rd,Chengxi St, Wenling 317500, Peoples R China.
RP Tan, JL (通讯作者)，First Peoples Hosp Wenling, Dept Burns & Plast Surg, 333 Chuanan South Rd,Chengxi St, Wenling 317500, Peoples R China.
EM tanjinglei@21cn.com
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NR 24
TC 13
Z9 18
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD APR
PY 2023
VL 89
IS 4
BP 1018
EP 1023
AR 00031348211054527
DI 10.1177/00031348211054527
EA NOV 2021
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J0VJ9
UT WOS:000721922400001
PM 34797180
DA 2026-07-24
ER
PT J
AU Patel, BJ
   Asher, CM
   Bystrzonowski, N
   Healy, C
AF Patel, Benjamin J.
   Asher, Christian M.
   Bystrzonowski, Nicola
   Healy, Ciaran
TI Safeguarding Skin Grafts An Evidence-Based Summary of Fixation
   Techniques
SO ANNALS OF PLASTIC SURGERY
LA English
DT Review
DE skin graft; plastic surgery; fibrin glue; tie-over bolster; negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; RANDOMIZED
   CONTROLLED-TRIAL; OVER BOLSTER DRESSINGS; FIBRIN SEALANT; BURN WOUNDS;
   THICKNESS; EFFICACY; DEVICE; GLUE
AB Background Effective skin graft fixation is vital in preventing sheering forces, seroma, and hematoma from compromising graft take. Yet, selecting the ideal technique for securing skin grafts remains a contentious subject, with significant variation in practice existing between surgeons. There is, therefore, benefit to be derived from assessing the literature for evidence-based recommendations to guide the decision-making process. Methods A search of Medline and Embase was performed using appropriate key terms, yielding 419 articles. Reference lists were analyzed. Inclusion and exclusion criteria were composed. Level I to III studies, as defined by the Centre for Evidence-Based Medicine, that compared skin graft fixation methods were analyzed. Rayyan QCRI was used for abstract and title screening. After full text screening, 41 studies were included for qualitative analysis. All included randomized control trials (RCTs) were assessed for risk of bias using the Cochrane Risk-of-Bias 2 (ROB2) tool. Results We identified 4 groups of fixation technique: "tie-over bolster" (TOB), "no TOB," "adhesive glues," and "negative pressure wound therapy" (NPWT). Twelve studies compared TOB with no TOB, with no difference in graft take demonstrated. Sixteen studies compared adhesive glues with traditional methods, with no difference in graft take demonstrated. Thirteen studies compared NPWT with traditional methods, with enhanced graft take demonstrated. Risk of bias was deemed low in 1 of 13 RCTs. Conclusions Based on the current evidence, only NPWT is associated with enhanced graft take. However, there is a scarcity of robust level I evidence comparing different fixation techniques, meaning that strong recommendations cannot be made. We propose examples of hypothesis-driven RCTs, in predetermined clinical settings, based on the theoretical benefits of the techniques that would add value to clinical practice.
C1 [Patel, Benjamin J.; Asher, Christian M.; Bystrzonowski, Nicola; Healy, Ciaran] Guys & St Thomas NHS Fdn Trust, Dept Plast Surg, London, England.
C3 Guy's & St Thomas' NHS Foundation Trust
RP Patel, BJ (通讯作者)，Southmead Hosp, Southmead Rd, Bristol BS10 5NB, Avon, England.
EM benjpatel@gmail.com
RI Asher, Christian/AAK-5121-2020
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U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2021
VL 87
IS 6
BP E180
EP E188
DI 10.1097/SAP.0000000000002937
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XC4HA
UT WOS:000721974600009
PM 34117134
DA 2026-07-24
ER
PT J
AU Abe, Y
   Ishida, S
   Mineda, K
   Yamashita, Y
   Nagasaka, S
   Yamasaki, H
   Hashimoto, I
AF Abe, Yoshiro
   Ishida, Soushi
   Mineda, Kazuhide
   Yamashita, Yutaro
   Nagasaka, Shinji
   Yamasaki, Hiroyuki
   Hashimoto, Ichiro
TI One-Stage Perifascial Areolar Tissue and Skin Grafting Combined with
   Negative Pressure Wound Therapy for a Refractory Wound with an Exposed
   Elbow Joint and Extensive Skin Defect
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Elbow joint exposure; Perifascial areolar tissue; Negative pressure
   wound therapy; One-stage PAT and skin grafting combined with NPWT; Soft
   tissue sarcoma
ID VACUUM-ASSISTED CLOSURE; MICROCIRCULATION; BONE
AB Joint exposure with an extensive skin defect following soft tissue tumor resection might cause a refractory ulcer. Although a vascularized tissue transplant is ideal for ulcer treatment, it is a highly invasive procedure and usually unsuitable for older patients with general prostration. One-stage perifascial areolar tissue (PAT) and skin grafting combined with negative pressure wound therapy (NPWT) is less invasive and effective procedure for refractory wounds with exposed bones and tendons. This is the first case where this procedure was used to treat a wound that involved an exposed elbow joint with an extensive skin defect. An 80-year-old woman underwent wide excision to remove a leiomyosarcoma on the olecranon with reconstruction using an ipsilateral pedicled latissimus dorsi musculocutaneous flap. The distal three-quarter of the flap was necrosed owing to insufficient blood supply. Furthermore, an articular capsule deficit of 1.5 x 1.0 cm(2) was found during necrotomy. The PAT was harvested from the lower abdomen as a non-vascularized tissue, and the articular capsule deficit was covered by overlapping on the granulation tissue around the deficit. Simultaneous split-thickness skin grafting combined with NPWT was applied on the PAT and residual skin defect. Wound healing was achieved in 4 weeks postoperatively without synovial fluid leakage. Elbow joint motion ranging from 0 to 120 degrees was maintained 18 months postoperatively. This procedure helped achieve better wound healing and sufficient functional outcome. Furthermore, this can help decrease patients' burden by preventing invasive resections associated with severe functional impairments or long-term rehabilitation requirements.
C1 [Abe, Yoshiro; Ishida, Soushi; Mineda, Kazuhide; Yamashita, Yutaro; Nagasaka, Shinji; Yamasaki, Hiroyuki; Hashimoto, Ichiro] Tokushima Univ, Dept Plast & Reconstruct Surg, Grad Sch Biomed Sci, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
C3 Tokushima University
RP Abe, Y (通讯作者)，Tokushima Univ, Dept Plast & Reconstruct Surg, Grad Sch Biomed Sci, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
EM y.abe@tokushima-u.ac.jp
RI ; /AFK-5986-2022
OI Abe, Yoshiro/0000-0002-7445-2857; yamashita, yutaro/0000-0002-8044-0721;
   
CR Abe Y, 2018, J MED INVESTIG, V65, P96, DOI 10.2152/jmi.65.96
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NR 26
TC 0
Z9 1
U1 0
U2 1
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD OCT
PY 2022
VL 84
IS 5
BP 1067
EP 1073
DI 10.1007/s12262-021-03188-0
EA NOV 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5N0OT
UT WOS:000723525200002
DA 2026-07-24
ER
PT J
AU Goldberg, B
   Elazar, A
   Glatt, A
   Camins, B
   Datta, R
   Takahashi, H
   Seitelman, E
AF Goldberg, Braden
   Elazar, Amit
   Glatt, Aaron
   Camins, Bernard
   Datta, Rajiv
   Takahashi, Hideo
   Seitelman, Eric
TI Perioperative Interventions to Reduce Surgical Site Infections: A Review
SO AORN JOURNAL
LA English
DT Review
DE surgical site infection (SSI); preoperative skin antisepsis;
   triclosan-coated suture (TCS); negative pressure wound therapy (NPWT);
   SSI prevention bundle
ID PRESSURE-WOUND-THERAPY; CARE-ASSOCIATED INFECTIONS; TRICLOSAN-COATED
   SUTURES; SKIN PREPARATION; POVIDONE-IODINE; PREVENTION; METAANALYSIS;
   CLOSURE; SURGERY; CHLORHEXIDINE
AB Surgical site infections (SSIs) contribute to increased health care costs and morbidity after procedures as well as prolonged length of stay. Perioperative personnel can use a variety of interventions to help reduce SSI incidence; however, all strategies are not effective for all patients (eg, antibiotic prophylaxis). Results of randomized controlled trials show that some SSI reduction strategies are generally effective, including preoperative skin antisepsis with an alcohol-based agent, closing surgical wounds with triclosan-coated suture, and applying a negative pressure wound therapy device to open and closed wounds. Study results do not show that irrigating clean wounds with crystalloid solutions containing antibiotics or routinely using plastic drapes with or without impregnated iodophor or silver nylon-impregnated dressings significantly reduces SSI incidence. Perioperative leaders should support the implementation of strategies to prevent SSIs and work with interdisciplinary team members to develop an SSI prevention bundle that will meet the needs of their patients.
C1 [Goldberg, Braden; Elazar, Amit; Datta, Rajiv; Seitelman, Eric] Mt Sinai South Nassau, Dept Surg, Oceanside, NY USA.
   [Glatt, Aaron] Mt Sinai South Nassau, Dept Med, Oceanside, NY USA.
   [Camins, Bernard] Mt Sinai Hosp, Med, New York, NY 10029 USA.
   [Takahashi, Hideo] Mt Sinai South Nassau, Dept Surg, Surg, Oceanside, NY 11570 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Takahashi, H (通讯作者)，Mt Sinai South Nassau, Dept Surg, Surg, Oceanside, NY 11570 USA.
EM hideo.takahashi@snch.org
RI ; Takahashi, Hideo/ABC-7429-2020
OI Goldberg, Braden/0009-0001-7091-3345; Camins,
   Bernard/0009-0006-6681-8093; 
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NR 60
TC 8
Z9 9
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-2092
EI 1878-0369
J9 AORN J
JI AORN J.
PD DEC
PY 2021
VL 114
IS 6
BP 587
EP 596
DI 10.1002/aorn.13564
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA XE9LA
UT WOS:000723701900015
PM 34846740
DA 2026-07-24
ER
PT J
AU Hamaguchi, R
   Shekar, PS
   Johnson, JA
   Orgill, DP
AF Hamaguchi, Ryoko
   Shekar, Prem S.
   Johnson, Jennifer A.
   Orgill, Dennis P.
TI Current Management of Sternal Wounds
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SEQUENTIAL LUNG TRANSPLANTATION;
   POST-STERNOTOMY MEDIASTINITIS; GENTAMICIN-COLLAGEN SPONGE; INTERNAL
   MAMMARY ARTERY; TIGHT GLYCEMIC CONTROL; BYPASS GRAFT-SURGERY;
   OPEN-HEART-SURGERY; HIGH-RISK PATIENTS; NEGATIVE-PRESSURE
AB Learning Objectives: After studying this article, the participant should be able to: 1. Describe the pathogenesis, classification, and risk factors of sternal wound infection. 2. Discuss options for sternal stabilization for the prevention of sternal wound infection, including wiring and plating techniques. 3. Discuss primary surgical reconstructive options for deep sternal wound infection and the use of adjunctive methods, such as negative-pressure wound therapy.
   Summary: Poststernotomy sternal wound infection remains a life-threatening complication of open cardiac surgery. Successful treatment relies on timely diagnosis and initiation of multidisciplinary, multimodal therapy.
C1 [Orgill, Dennis P.] Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   Brigham & Womens Hosp, Div Cardiac Surg, Boston, MA 02115 USA.
   Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@bwh.harvard.edu
RI Orgill, Dennis/H-7596-2019
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   Wu LZ, 2016, PLAST RECONSTR SURG, V137, p414E, DOI 10.1097/01.prs.0000475785.14328.b2
   Zerr KJ, 1997, ANN THORAC SURG, V63, P356
NR 77
TC 12
Z9 15
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2021
VL 148
IS 6
BP 1012E
EP 1025E
DI 10.1097/PRS.0000000000008510
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XF1FU
UT WOS:000723823800014
PM 34847131
DA 2026-07-24
ER
PT J
AU Ogur, HU
   Kapukaya, R
   Çiloglu, O
   Külahci, O
   Tekbas, VT
   Yörükoglu, A
AF Ogur, Hasan Ulas
   Kapukaya, Rana
   Ciloglu, Osman
   Kulahci, Ozgur
   Tekbas, Volkan Tolga
   Yorukoglu, Abdulkerim
TI Treatment of open wounds secondary to trauma using polyurethane foams
   with boric acid particles
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Boric acid particle; boron foams; the negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE; IN-VITRO; SILVER; BORON;
   ANTISEPTICS; MECHANISMS; THERAPY
AB BACKGROUND: To investigate the efficacy of new foams with boric acid particles combined with a negative pressure wound treatment (NPWT) system in open fractures with tissue defects secondary to trauma. METHODS: Forty-nine patients with open fractures secondary to trauma with soft tissue defects who were admitted between 2016 and 2018 were included in the study. Patients were examined in two groups. In Group 1, boric acid-impregnated foams combined with the NPWT system were used in 27 patients, and in Group 2, silver nitrate-impregnated foams combined with NPWT systems were used in 22 patients. In addition to evaluating the broad-spectrum antibacterial feature of silver nitrate, the antimicrobial, angiogenetic, and epithelializing effects of boric acid were investigated macroscopically and histopathologically. RESULTS: A reduction in wound size and granulation was observed in each group. Macroscopically, the reduction in wound size, epithelialization and granulation were pronounced in Group 1 and in Group 2. Microscopically, the number of fibroblasts, collagen synthesis, and angiogenesis were significantly increased in Group 1 compared with Group 2. CONCLUSION: In this clinical trial, both the broad spectrum antimicrobial feature of boric acid and its positive effect on the cells responsible for wound healing were found to be an alternative compared with silver nitrate. The use of new foams with boric acid particles combined with the NPWT system may be a good alternative method in the treatment of open wounds due to trauma.
C1 [Ogur, Hasan Ulas; Ciloglu, Osman; Tekbas, Volkan Tolga] Adana City Training & Res Hosp, Dept Orthopaed & Traumatol, Adana, Turkey.
   [Kapukaya, Rana] Adana City Training & Res Hosp, Dept Plast & Reconstruct Surg, Adana, Turkey.
   [Kulahci, Ozgur] Adana City Training & Res Hosp, Dept Med Pathol, Adana, Turkey.
   [Yorukoglu, Abdulkerim] Natl Boron Inst, Ankara, Turkey.
C3 Adana Numune Training & Research Hospital; Adana Numune Training &
   Research Hospital; Adana Numune Training & Research Hospital
RP Ogur, HU (通讯作者)，Adana Sehir Egitim & Arastirma Hastanesi, Ortopedi & Travmatol Klin, Adana, Turkey.
EM hasanulas@yahoo.com
RI KAPUKAYA, RANA/HKE-5389-2023; Yörükoğlu, Abdulkerim/AAR-5664-2021;
   ciloglu, osman/QKY-0989-2026; Külahcı, Özgür/AGG-0591-2022
OI KAPUKAYA, RANA/0000-0001-9709-328X; Tekbaş, Volkan
   Tolga/0000-0002-6462-2728; 
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NR 30
TC 3
Z9 4
U1 0
U2 6
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD NOV
PY 2021
VL 27
IS 6
BP 624
EP 630
DI 10.14744/tjtes.2020.38613
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA XF1GS
UT WOS:000723826200004
PM 34710221
OA hybrid
DA 2026-07-24
ER
PT J
AU Shi, H
   Zhu, L
   Chen, L
   Jiang, ZL
   Xu, ZY
   Wu, XT
AF Shi, Hang
   Zhu, Lei
   Chen, Lu
   Jiang, Zan-Li
   Xu, Zheng-Yuan
   Wu, Xiao-Tao
TI A Novel Technique for Treating Early Deep Surgical Site Infection After
   Posterior Lumbar Fusion with Instrumentation
SO WORLD NEUROSURGERY
LA English
DT Article
DE -Stage incision suture; Closed suction irrigation system; Deep surgical
   site infection; Incisional vacuum-assisted closure; Posterior lumbar
   fusion with instrumentation
ID PRESSURE WOUND THERAPY; ERYTHROCYTE SEDIMENTATION-RATE; C-REACTIVE
   PROTEIN; SPINAL SURGERY; CONTINUOUS-IRRIGATION; COMPLICATIONS;
   DEHISCENCE; PREVENTION; PREDICTOR
AB -OBJECTIVE: To introduce a novel technique of using incisional vacuum-assisted closure (VAC) after 1-stage incision suture combined with closed suction irrigation system (CSIS) for treating early deep surgical site infection (SSI) after posterior lumbar fusion with instrumentation and to compare it with traditional CSIS. -METHODS: This was a retrospective study. Patients with early deep SSI after posterior lumbar fusion with instru-mentation from January 2013 to May 2020 who were treated by meticulous debridement followed by either CSIS or incisional VAC after 1-stage incision suture combined with CSIS were identified. The demographic characteristics, treatment features, and outcomes were analyzed and compared between the 2 treatment methods. -RESULTS: A total of 48 patients (48/5016, 0.96%) devel -oped early deep SSI, 46 of whom were enrolled in this study. This included 24 patients in the CSIS group (group 1) and 22 patients in the incisional VAC after 1-stage incision suture combined with CSIS group (group 2). All patients received follow-up, with an average of 19.7 months (range, 13e30 months). There were no significant differences in demographic characteristics in both groups (P > 0.05). The -umber of VAC foam dressing or ordinary dressing changes (P < 0.001), number of debridements (P = 0.028), intrave-nous antibiotic duration (P = 0.042), oral antibiotic dura-tion (P = 0.019), and hospital stay (P = 0.029) in group 1 were significantly higher than those in group 2. The irrigation duration in group 1 was significantly shorter than that in group 2 (P = 0.007). All patients were eventually cured with satisfactory outcomes. -CONCLUSIONS: Compared with CSIS, incisional VAC after 1-stage incision suture combined with CSIS may be recommended considering that it has fewer dressing changes, fewer debridements, longer irrigation duration, shorter duration of antibiotic use, shorter hospital stay, and more convenient nursing care.
C1 [Shi, Hang; Zhu, Lei; Chen, Lu; Jiang, Zan-Li; Xu, Zheng-Yuan; Wu, Xiao-Tao] Southeast Univ, Zhongda Hosp, Sch Med, Dept Spine Surg, Nanjing, Peoples R China.
C3 Southeast University - China
RP Wu, XT (通讯作者)，Southeast Univ, Zhongda Hosp, Sch Med, Dept Spine Surg, Nanjing, Peoples R China.
EM wuxiaotaospine@seu.edu.cn
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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   THELANDER U, 1992, SPINE, V17, P400, DOI 10.1097/00007632-199204000-00004
   Yuan W, 2018, SPINE, V43, pE1089, DOI 10.1097/BRS.0000000000002615
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   Zheng S, 2020, INT ORTHOP, V44, P2211, DOI 10.1007/s00264-020-04567-0
   Zhou JM, 2020, SPINE, V45, P208, DOI 10.1097/BRS.0000000000003218
NR 32
TC 4
Z9 5
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD DEC
PY 2021
VL 156
BP E167
EP E174
DI 10.1016/j.wneu.2021.09.016
EA NOV 2021
PG 8
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA XG8VJ
UT WOS:000725025500034
PM 34509677
DA 2026-07-24
ER
PT J
AU Haque, S
   Kanapathy, M
   Bollen, E
   Mosahebi, A
   Younis, I
AF Haque, Shameem
   Kanapathy, Muholan
   Bollen, Edward
   Mosahebi, Afshin
   Younis, Ibby
TI Patient-reported outcome and cost implication of acute salvage of
   infected implant-based breast reconstruction with negative pressure
   wound therapy with Instillation (NPWTi) compared to standard care
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Cost; Patient reported outcome; Breast implant; Infection; NPWTi
ID COMPLICATIONS; SATISFACTION; SURGERY; FLAP
AB Introduction: Implant loss due to infection is the most devastating complication of implant-based breast reconstruction. The use of negative pressure wound therapy with instillation(NPWTi) for salvage of infected implant-based breast reconstructions has shown promising results allowing early reinsertion of a new implant as an alternative to the current management with delayed reinsertion. This study compares the patient-reported outcome and cost implication of NPWTi to the current management.
   Methods: Twenty cases of infected breast implants treated with NPWTi(V.A.C. VERAFLO (TM) Therapy), followed by early reinsertion of new implants were compared to 20 cases that had delayed reinsertion(non-NPWTi). Patient satisfaction was evaluated using the BREAST-Q questionnaire. The average cost per patient was calculated using total operative expense, cost of inpatient stay, investigations, antibiotics, and outpatient visits.
   Results: Treatment with NPWTi allowed earlier reinsertion of a new implant (NPWTi: 10.3 +/- 2.77days vs. non-NPWTi: 247.45 +/- 111.28days, p < 0.001). Patients in the NPWTi group reported higher satisfaction. The average cost per patient for NPWTi and non-NPWTi was 14,343.13 pound +/-2,786.70 pound and 8,920.31 pound +/-3,005.73 pound, respectively(p<0.001). All patients treated with NPWTi had one admission and spent 11.9 +/- 4.1days as inpatients, while non-NPWTi patients had 2.1 +/- 0.3 admissions(p<0.001) and spent 7.1 +/- 5.8days(p<0.004) as inpatients. Patients treated with NPWTi had more procedures (NPWTi:3.35 +/- 0.81 Vs. non-NPWTi:2.2 +/- 0.41, p = 0.006); however, three non-NPWTi cases required flap reconstruction.
   Conclusion: Patients treated with NPWTi reported higher satisfaction, received a new and earlier implant, and had fewer admissions and outpatient visits; however, they incurred higher average costs, longer inpatient stays, and underwent more procedures. Early implant reinsertion preserves skin envelope; hence avoiding additional cost and stress related to further major autologous reconstruction. (C) 2021 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.
C1 [Haque, Shameem; Kanapathy, Muholan; Mosahebi, Afshin; Younis, Ibby] Royal Free NHS Fdn Trust Hosp, Dept Plast & Reconstruct Surg, London NW3 2QG, England.
   [Kanapathy, Muholan; Mosahebi, Afshin] UCL, Div Surg & Intervent Sci, London, England.
   [Bollen, Edward] UCL, UCL Med Sch, London, England.
C3 University of London; University College London; University of London;
   University College London
RP Kanapathy, M (通讯作者)，Royal Free NHS Fdn Trust Hosp, Dept Plast & Reconstruct Surg, London NW3 2QG, England.; Kanapathy, M (通讯作者)，UCL, Div Surg & Intervent Sci, London, England.
EM m.kanapathy@ucl.ac.uk
RI Kanapathy, Muholan/B-2225-2016
CR Atherton DD, 2011, J PLAST RECONSTR AES, V64, P710, DOI 10.1016/j.bjps.2010.11.001
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NR 22
TC 13
Z9 16
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2021
VL 74
IS 12
BP 3300
EP 3306
DI 10.1016/j.bjps.2021.05.014
EA NOV 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XG9IZ
UT WOS:000725060900007
PM 34217644
DA 2026-07-24
ER
PT J
AU Yakkanti, RR
   Mohile, N
   Cohen-Levy, WB
   Haziza, S
   Lavelle, MJ
   Bellam, KG
   Quinnan, SM
AF Yakkanti, Ramakanth R.
   Mohile, Neil, V
   Cohen-Levy, Wayne B.
   Haziza, Sagie
   Lavelle, Matthew J.
   Bellam, Krishna G.
   Quinnan, Stephen M.
TI Perioperative management of acetabular and pelvic fractures:
   evidence-based recommendations
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE Pelvic fracture; Acetabular fracture; Concept review; Time to fixation;
   Tranexamic acid; Heterotopic ossification
ID VENA-CAVA FILTERS; PRESSURE WOUND THERAPY; BLOOD-CELL SALVAGE;
   PREVENTING HETEROTOPIC OSSIFICATION; SURGICAL SITE INFECTIONS;
   TRANEXAMIC ACID; TRAUMA PATIENTS; VENOUS THROMBOEMBOLISM; RISK-FACTORS;
   INTERNAL-FIXATION
AB Purpose The American Academy of Orthopaedic Surgeons does not currently provide clinical practice guidelines for management of PAF. Accordingly, this article aims to review and consolidate the relevant historical and recent literature in important topics pertaining to perioperative management of PAF. Methods A thorough literature review using PubMed, Cochrane and Embase databases was performed to assess preoperative, intraoperative and postoperative management of PAF fracture. Topics reviewed included: time from injury to definitive fixation, the role of inferior vena cava filters (IVCF), tranexamic acid (TXA) use, intraopoperative cell salvage, incisional negative pressure wound therapy (NPWT), intraoperative antibiotic powder use, heterotopic ossification prophylaxis, and pre- and postoperative venous thromboembolism (VTE) prophylaxis. Results A total of 126 articles pertaining to the preoperative, intraoperative and postoperative management of PAF were reviewed. Articles reviewed by topic include 13 articles pertaining to time to fixation, 23 on IVCF use, 14 on VTE prophylaxis, 20 on TXA use, 10 on cell salvage, 10 on iNPWT 14 on intraoperative antibiotic powder and 20 on HO prophylaxis. An additional eight articles were reviewed to describe background information. Five articles provided information for two or more treatment modalities and were therefore included in multiple categories when tabulating the number of articles reviewed per topic. Conclusion The literature supports the use of radiation therapy for HO prophylaxis, early (< 5 days from injury) surgical intervention and the routine use of intraoperative TXA. The literature does not support the routine use of iNPWT or IVCF. There is inadequate information to make a recommendation regarding the use of cell salvage and wound infiltration with antibiotic powder. While the routine use of chemical VTE prophylaxis is recommended, there is insufficient evidence to recommend the optimal agent and duration of therapy.
C1 [Yakkanti, Ramakanth R.; Mohile, Neil, V; Haziza, Sagie; Lavelle, Matthew J.] Univ Miami, Dept Orthopaed Surg, Univ Hosp, 1321 NW 14th St,Suite 306, Miami, FL 33125 USA.
   [Cohen-Levy, Wayne B.] Case Western Reserve Univ, Univ Hosp, Cleveland, OH 44106 USA.
   [Bellam, Krishna G.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Quinnan, Stephen M.] Paley Orthoped & Spine Inst, W Palm Beach, FL USA.
C3 University of Miami; University System of Ohio; Case Western Reserve
   University; University Hospitals of Cleveland; Brown University
RP Haziza, S (通讯作者)，Univ Miami, Dept Orthopaed Surg, Univ Hosp, 1321 NW 14th St,Suite 306, Miami, FL 33125 USA.
EM Sagiehaziza@gmail.com
RI Yakkanti, Ramakanth/AAC-4316-2020
OI Yakkanti, Ramakanth/0000-0001-7112-0139; Haziza,
   Sagie/0000-0003-2799-1134
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NR 126
TC 7
Z9 10
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD MAR
PY 2023
VL 143
IS 3
BP 1311
EP 1321
DI 10.1007/s00402-021-04278-0
EA DEC 2021
PG 11
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA ER9Y8
UT WOS:000725382200001
PM 34854977
DA 2026-07-24
ER
PT J
AU Chen, CY
   Kuo, SM
   Tarng, YW
   Lin, KC
AF Chen, Chun-Yu
   Kuo, Shyh-Ming
   Tarng, Yih-Wen
   Lin, Kai-Cheng
TI Immediate application of negative pressure wound therapy following lower
   extremity flap reconstruction in sixteen patients
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAPS; CONGESTION; SAFETY
AB Negative pressure wound therapy (NPWT) is usually applied in wound management and soft-tissue salvage after the development of complications. However, immediate postoperative application of NPWT over the flap coverage is seldom reported. We evaluate the effectiveness of immediate postoperative application of NPWT following fasciocutaneous or muscle flap coverage for lower leg reconstruction. A retrospective review of patients who underwent either fasciocutaneous or muscle flap coverage of lower leg soft-tissue defects applied with NPWT immediately after surgery was conducted in a level I trauma center. Sixteen patients, with an average age of 51.2 years, were included in the study. Nine patients had trauma-related soft-tissue loss, six had subsequent soft-tissue defects after debridement, and one had burn injury. Two patients had been treated with free anterolateral thigh flaps, 11 with pedicle flaps, and three with muscle flaps. All flaps survived except for those in two patients with venous congestion on postoperative day 1, which needed further debridement and skin grafting. Therefore, the use of immediate incisional NPWT is an alternative for wound care following flap coverage. The U-shaped design allows easy flap observation and temperature check. Furthermore, this method eliminates any concerns of vascular pedicle compression under negative pressure.
C1 [Chen, Chun-Yu; Tarng, Yih-Wen; Lin, Kai-Cheng] Kaohsiung Vet Gen Hosp, Dept Orthopaed, 386 Ta Chung 1st Rd, Kaohsiung, Taiwan.
   [Chen, Chun-Yu; Lin, Kai-Cheng] Shu Zen Jr Coll Med & Management, Dept Occupat Therapy, Kaohsiung, Taiwan.
   [Chen, Chun-Yu; Kuo, Shyh-Ming] I Shou Univ, Dept Biomed Engn, Kaohsiung, Taiwan.
C3 Kaohsiung Veterans General Hospital; I Shou University
RP Lin, KC (通讯作者)，Kaohsiung Vet Gen Hosp, Dept Orthopaed, 386 Ta Chung 1st Rd, Kaohsiung, Taiwan.; Lin, KC (通讯作者)，Shu Zen Jr Coll Med & Management, Dept Occupat Therapy, Kaohsiung, Taiwan.
EM orthokcl@gmail.com
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NR 31
TC 11
Z9 16
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 27
PY 2021
VL 11
IS 1
AR 21158
DI 10.1038/s41598-021-00369-5
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA XK1JP
UT WOS:000727230500009
PM 34707109
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Salem, HS
   Sherman, AE
   Chen, ZM
   Scuderi, GR
   Mont, MA
AF Salem, Hytham S.
   Sherman, Alain E.
   Chen, Zhongming
   Scuderi, Giles R.
   Mont, Michael A.
TI The Utility of Perioperative Products for the Prevention of Surgical
   Site Infections in Total Knee Arthroplasty and Lower Extremity
   Arthroplasty: A Systematic Review
SO JOURNAL OF KNEE SURGERY
LA English
DT Review
DE total knee arthroplasty; perioperative products; surgical site
   infections; Systematic Review
ID TOTAL JOINT ARTHROPLASTY; PRESSURE WOUND THERAPY; RESISTANT
   STAPHYLOCOCCUS-AUREUS; ORTHOPEDIC-SURGERY; TOTAL HIP; PREOPERATIVE
   DECOLONIZATION; BACTERIAL-CONTAMINATION; RISK-FACTORS; MAINTAINS
   NORMOTHERMIA; WARMING BLANKETS
AB Surgical site infections (SSIs) are among the most prevalent and devastating complications following lower extremity total joint arthroplasty (TJA). Strategies to reduce the rates can be divided into preoperative, perioperatives, and postoperative measures. A multicenter trial is underway to evaluate the efficacy of implementing a bundled care program for SSI prevention in lower extremity TJA including: (1) nasal decolonization; (2) surgical skin antisepsis; (3) antimicrobial incise draping; (4) temperature management; and (5) negative-pressure wound therapy for selected high-risk patients. The purposes of this systematic review were to provide a background and then to summarize the available evidence pertaining to each of these SSI-reduction strategies with special emphasis on total knee arthroplasty. A systematic review of the literature was conducted in accordance with the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines. Five individual literature searches were performed to identify studies evaluating nasal decolonization temperature management, surgical skin antisepsis, antimicrobial incise draping, and negative-pressure wound therapy. The highest level of evidence reports was used in each product review, and if there were insufficient arthroplasty papers on the particular topic, then papers were further culled from the surgical specialties to form the basis for the review. There was sufficient literature to assess all of the various prophylactic and preventative techniques. All five products used in the bundled program were supported for use as prophylactic agents or for the direct reduction of SSIs in both level I and II studies. This systematic review showed that various pre-, intra-, and postoperative strategies are efficacious in decreasing the risks of SSIs following lower extremity TJA procedures. Thus, including them in the armamentarium for SSI-reduction strategies for hip and knee arthroplasty surgeons should decrease the incidence of infections. We expect that the combined use of these products in an upcoming study will support these findings and may further enhance the reduction of total knee arthroplasty SSIs in a synergistic manner.
C1 [Salem, Hytham S.; Sherman, Alain E.; Chen, Zhongming; Scuderi, Giles R.; Mont, Michael A.] Northwell Hlth Orthopaed, Lenox Hill Hosp, 130 East 77th St,11th Floor, New York, NY 10075 USA.
   [Salem, Hytham S.; Chen, Zhongming; Mont, Michael A.] Sinai Hosp Baltimore, Ctr Joint Preservat & Replacement, Rubin Inst Adv Orthoped, Baltimore, MD USA.
C3 Northwell Health; Sinai Hospital of Baltimore
RP Mont, MA (通讯作者)，Northwell Hlth Orthopaed, Lenox Hill Hosp, 130 East 77th St,11th Floor, New York, NY 10075 USA.
EM rhondamont@aol.com
OI Chen, Zhongming/0000-0001-9647-7193
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NR 157
TC 4
Z9 5
U1 0
U2 6
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 1538-8506
EI 1938-2480
J9 J KNEE SURG
JI J. Knee Surg.
PD JUL
PY 2022
VL 35
IS 09
BP 1023
EP 1043
DI 10.1055/s-0041-1740394
EA DEC 2021
PG 21
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 3P8NG
UT WOS:000727677200001
PM 34875715
DA 2026-07-24
ER
PT J
AU Kim, TH
   Park, JH
AF Kim, Tae Hyung
   Park, Jun Ho
TI A novel negative pressure wound therapy (NPWT) monitoring system for
   postoperative flap management
SO MEDICINE
LA English
DT Article
DE free flap; negative pressure wound therapy; pedicled flap
ID VACUUM-ASSISTED CLOSURE; VENOUS CONGESTION; RECONSTRUCTION; SURVIVAL;
   OUTCOMES; SALVAGE; TISSUE
AB Various types of flaps are widely utilized as reconstructive options for patients with soft tissue defects. However, the postoperative monitoring of the flap requires a large amount of time and effort. The aim of this study was to evaluate the efficacy and safety of this novel monitoring procedure using negative pressure wound therapy (NPWT) immediately after the flap operations. A retrospective analysis was performed on patients who underwent free flaps and perforator flaps from March 2019 to December 2020. The flaps were managed by either novel NPWT method or conventional dressing. Among NPWT group, computed tomography angiography was performed in randomly selected 5 flaps on the third postoperative day for evaluation of pedicle compression. Statistical analysis was performed between the 2 groups. A total of 54 flaps were included in this study. Twenty seven flaps were managed using novel NPWT method and 27 flaps were managed using conventional dressing. There was no statistically significant difference in flap survival rates between the 2 groups (P = .91). The patency of flap pedicles in the NPWT group was confirmed by comparing the computed tomography angiography findings. The estimated total flap monitoring time and cost for 5 days was significantly decreased by the application of the novel NPWT monitoring system. Through the application of the novel postoperative monitoring system using NPWT, there is efficient evaluation of the flap. Furthermore, safe flap monitoring is possible with the reduced risk of infection by the avoidance of multiple manual dressing performed in the conventional method.
C1 [Kim, Tae Hyung; Park, Jun Ho] Soonchunhyang Univ, Dept Plast & Reconstruct Surg, Gumi Hosp, 1 Gongdan Ro 179, Gumi, Gyeonsangbuk Do, South Korea.
C3 Soonchunhyang University
RP Park, JH (通讯作者)，Seoul Natl Univ, Coll Med, Dept Plast & Reconstruct Surg, SMG SNU Boramae Med Ctr, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea.
EM jsean1@naver.com
OI Park, Jun Ho/0000-0003-0235-1261
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   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Semsarzadeh NN, 2015, PLAST RECONSTR SURG, V136, P592, DOI 10.1097/PRS.0000000000001519
   Swartz JE, 2015, CLIN OTOLARYNGOL, V40, P600, DOI 10.1111/coa.12425
   Uygur F, 2008, INT WOUND J, V5, P50, DOI 10.1111/j.1742-481X.2007.00362.x
   Vaienti L, 2013, J ORTHOP TRAUMATOL, V14, P213, DOI 10.1007/s10195-013-0236-0
   Wei F-C., 2018, PLAST SURG-CHIR PLAS, V4th, P444
   Yin YC, 2018, INT J SURG, V50, P43, DOI 10.1016/j.ijsu.2017.12.020
   Yu PX, 2017, J RECONSTR MICROSURG, V33, P358, DOI 10.1055/s-0037-1599076
NR 30
TC 5
Z9 7
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV 5
PY 2021
VL 100
IS 44
AR e27671
DI 10.1097/MD.0000000000027671
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA XL2QA
UT WOS:000727992700001
PM 34871244
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Isoherranen, K
   Kluger, N
   Hannula-Jouppi, K
   Väkevä, L
AF Isoherranen, Kirsi
   Kluger, Nicolas
   Hannula-Jouppi, Katariina
   Vakeva, Liisa
TI The Role of Negative Pressure Wound Therapy (NPWT) in the Management of
   Vasculitic Wounds: Case Series of Eight Patients
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE Inflammatory ulcer; atypical ulcer; cutaneous vasculitis; negative
   pressure wound therapy
ID HIDRADENITIS SUPPURATIVA; CLOSURE
AB Vasculitic ulcers belong to the category of atypical ulcers and are traditionally very slow to heal. The aim of this study is to retrospectively analyze the files of eight patients with vasculitic ulcers treated with negative pressure wound therapy (NPWT). Immunosuppression was initiated at least two weeks prior to starting NPWT. We suggest that this is a safe and promising protocol to treat these hard-to-heal ulcers.
C1 Univ Helsinki, Dept Dermatol & Allergol, Helsinki, Finland.
   Helsinki Univ Hosp, Inflammat Ctr, Helsinki, Finland.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital
RP Isoherranen, K (通讯作者)，Univ Helsinki, Cent Hosp, Skin & Allergy Hosp, Meilandentie 2, Helsinki 00250, Finland.
EM kirsi.isoherranen@hus.fi
OI Kluger, Nicolas/0000-0002-5225-8316; Isoherranen,
   Kirsi/0000-0002-0253-2567
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
   Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
   Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Bassetto F, 2012, J PLAST RECONSTR AES, V65, P91, DOI 10.1016/j.bjps.2011.08.016
   Cooper RL, 2015, J THEOR BIOL, V367, P86, DOI 10.1016/j.jtbi.2014.11.008
   Eisendle K, 2020, ADV WOUND CARE, V9, P405, DOI 10.1089/wound.2020.1160
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   Hartmann K, 2016, PHYSIOL REV, V96, P409, DOI 10.1152/physrev.00011.2015
   Hasan MY, 2015, DIABET FOOT ANKLE, V6, DOI 10.3402/dfa.v6.27618
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   Karam RA, 2018, GENE, V667, P56, DOI 10.1016/j.gene.2018.05.032
   Keskitalo S, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02770
   Labler L, 2006, ZBL CHIR, V131, pS62
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   Pichler M, 2016, J AM ACAD DERMATOL, V74, P760, DOI 10.1016/j.jaad.2015.09.009
   Shavit E, 2018, INT J LOW EXTR WOUND, V17, P218, DOI 10.1177/1534734618804982
   Steingräber AK, 2013, EXP DERMATOL, V22, P730, DOI 10.1111/exd.12253
   Sunderkötter CH, 2018, ARTHRITIS RHEUMATOL, V70, P171, DOI 10.1002/art.40375
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NR 24
TC 3
Z9 3
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2024
VL 23
IS 3
BP 445
EP 449
AR 15347346211063700
DI 10.1177/15347346211063700
EA DEC 2021
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA N9B6T
UT WOS:000729521900001
PM 34878340
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Klein, RJ
AF Klein, Robert J.
TI Managing Wound Dehiscence With Mechanical Negative Pressure Wound
   Therapy: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE mechanical negative pressure wound therapy; wound dehiscence; diabetic
   foot ulceration; negative pressure wound therapy; ray resection
AB Mechanical negative pressure wound therapy (mNPWT) is commonly used in the management of a variety of wounds, including diabetic foot ulcerations, surgical wounds, venous ulcerations, and wound dehiscence. This mechanically powered, disposable modality can be used to manage wounds in the outpatient setting and has been shown to be an effective wound care option when transitioning patients from the inpatient to outpatient setting and continuing NPWT for wound care. Mechanical NPWT helps promote wound healing by decreasing edema and via removal of tissue debris and exudate. Traditional NPWT is bulky, is often noisy, and requires a power source. A mechanically powered, disposable, easily applied, off-the-shelf mNPWT device is available for patients with small- to medium-sized wounds with mild to moderate exudate. The disposable mNPWT device provides -125 mm Hg pressure, is silent and small, can be worn under clothes, and allows the patient to be fully ambulatory, thus, more mobile. The mNPWT device tubing can be cut to fit to enable safer ambulation than the powered system and to enable the patient to work and enjoy social activities without a medical device showing. This single case study of a patient with chronic diabetic foot ulcerations of the medial first metatarsal head and dorsal proximal interphalangeal joints of the second and third toes of the left foot, which had not been successfully treated with conservative care and had been present for more than 1 year.
C1 [Klein, Robert J.] Wound Healing & Hyperbar Oxygen Ctr, Greenville, SC USA.
   [Klein, Robert J.] Univ South Carolina, Sch Med, Greenville, SC USA.
RP Klein, RJ (通讯作者)，200 Patewood Dr,Suite C300, Greenville, SC 29615 USA.
EM robklein63@gmail.com
CR Fong KD, 2010, WOUNDS, V22, P230
   Fong KD, 2010, PLAST RECONSTR SURG, V125, P1362, DOI 10.1097/PRS.0b013e3181d62b25
   Landers S, 2016, HOME HLTH CARE MAN P, V28, P262, DOI 10.1177/1084822316666368
   Lerman Bruce, 2010, J Diabetes Sci Technol, V4, P825
   Nussbaum SR, 2018, VALUE HEALTH, V21, P27, DOI 10.1016/j.jval.2017.07.007
   Tettelbach William, 2019, Wounds, V31, pS1
NR 6
TC 2
Z9 2
U1 2
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2021
VL 33
IS 12
BP E75
EP E78
DI 10.25270/wnds/2021.e7578
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA XN8PK
UT WOS:000729760700001
PM 34882095
DA 2026-07-24
ER
PT J
AU Willmore, J
   Wrotslavsky, P
AF Willmore, James
   Wrotslavsky, Philip
TI Preoperative contaminated wound management using short-term negative
   pressure wound therapy with instillation
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE diabetes; diabetic foot ulcer; dressing; infection; lower extremity;
   surgical wound dehiscence; ulcer; wound; wounds; wound cleansing; wound
   healing; wound treatment
ID LAVAGE; INFECTION; OUTBREAK; OUTCOMES
AB Background: The short-term application of negative pressure wound therapy with instillation and dwell time (NPWTi-d) enables the delivery of topical wound solutions, the solubilisation of debris and cleansing of the wound bed. The application of NPWTi-d may support the transition of the wound to a more manageable state and minimises the use of more invasive techniques.
   Method: In this case series, we describe the process of applying NPWTi-d early as part of a contaminated wound treatment plan.
   Results: The case series included 15 patients in the preoperative setting. Wound types included surgical dehiscence, hard-to-heal wounds, heel pressure ulcers, diabetic foot ulcers, a cat bite and an amputation left open. Normal saline or a 0.125% sodium hypochlorite solution were instilled and allowed to dwell for five minutes, followed by 15 minutes of continuous negative pressure at -125mmHg. NPWTi-d was continued for 4-36 hours, or until the operating room became available. After NPWTi-d, we observed a decreased amount of devitalised tissue in the wound bed and reduced oedema and erythema in the periwound area. Patient white blood cells also significantly decreased in all cases after NPWTi-d (p<0.001).
   Conclusion: Short-term use of NPWTi-d may be a useful option for supporting the surgical treatment of contaminated lower extremity wounds.
C1 [Willmore, James; Wrotslavsky, Philip] Adv Foot & Ankle Ctr San Diego, San Diego, CA 92121 USA.
RP Wrotslavsky, P (通讯作者)，Adv Foot & Ankle Ctr San Diego, San Diego, CA 92121 USA.
EM drphilipw@gmail.com
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NR 21
TC 6
Z9 6
U1 0
U2 4
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2021
VL 30
IS 12
BP 994
EP 1000
DI 10.12968/jowc.2021.30.12.994
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA XN8PR
UT WOS:000729761400005
PM 34882001
DA 2026-07-24
ER
PT J
AU Lim, XX
   Zhang, L
   Hong, QT
   Yong, EM
   Neo, S
   Chandrasekar, S
   Tan, GWL
   Lo, ZJ
AF Lim, Xuxin
   Zhang, Li
   Hong, Qiantai
   Yong, Enming
   Neo, Shufen
   Chandrasekar, Sadhana
   Tan, Glenn Wei Leong
   Lo, Zhiwen Joseph
TI Novel home use of mechanical negative pressure wound therapy in diabetic
   foot ulcers
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE diabetes; diabetic foot wounds; home therapy; leg wounds; limb salvage;
   mechanical negative pressure wound therapy; NPWT; outcomes; ulcers;
   wound; wound care; wound healing
ID MULTICENTER; DEVICE
AB Objective: Mechanical negative pressure wound therapy is an ultraportable, light weight and disposable single-use device that has been shown to promote wound healing. This study evaluated home use of a mechanically powered negative pressure wound therapy (NPWT) in diabetic foot wounds.
   Methods: Patients underwent revascularisation and/or debridement or amputation before starting mechanical NPWT. Wound outcomes and images of the wounds were recorded at each follow-up visit by the wound nurse. Patients were followed up until wound closure or end of therapy.
   Results: A total of 12 patients (each with one wound) were included in the study. Of the 12 wounds, 33.3% (n=4) of wounds achieved primary wound closure while the remaining 66.6% (n=8) of wounds demonstrated a mean wound size reduction of 37.5 +/- 0.13%. Of the closed wounds, mean time to healing was 4.75 +/- 2.50 weeks. There was 100% limb salvage with no further debridement or amputations, and no 30-day unplanned readmissions. Mean length of hospital stay before starting home NPWT was 9.75 +/- 6.31 days. Mean number of NPWT changes was 8.33 +/- 2.67 sessions, while mean duration of therapy was 4.0 +/- 1.54 weeks. Mean cost of home NWPT therapy was US$1904 +/- 731 per patient.
   Conclusion: The home use of mechanically powered NPWT in diabetic foot wounds demonstrated excellent wound healing rates and 100% limb salvage, with no complications.
C1 [Lim, Xuxin; Zhang, Li; Hong, Qiantai; Yong, Enming; Neo, Shufen; Chandrasekar, Sadhana; Tan, Glenn Wei Leong] Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, Singapore, Singapore.
   [Lo, Zhiwen Joseph] Woodlands Hlth, Vasc Surg Serv, Dept Surg, Singapore, Singapore.
C3 Tan Tock Seng Hospital
RP Lim, XX (通讯作者)，Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, Singapore, Singapore.
EM meghan.lim@mohh.com.sg
RI ; Yong, Enming/LXB-4566-2024
OI Chanasekar, Sadhana/0000-0002-3650-8020; Yong,
   Enming/0000-0002-9461-0066
CR Ang Y, 2017, PROC SINGAP HEALTHC, V26, P76, DOI 10.1177/2010105816663521
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   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Bommer C, 2018, DIABETES CARE, V41, P963, DOI 10.2337/dc17-1962
   Cuomo R, 2021, J INVEST SURG, V34, P335, DOI 10.1080/08941939.2019.1616009
   Dalla Paola L, 2013, INT WOUND J, V10, P25, DOI 10.1111/iwj.12174
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   Lim K, 2020, INT WOUND J, V17, P531, DOI 10.1111/iwj.13307
   Lo ZJ, 2020, INT WOUND J, V17, P790, DOI 10.1111/iwj.13333
   Lo ZWJ, 2018, ANN VASC SURG, V49, P9, DOI 10.1016/j.avsg.2018.01.061
   Marston WA, 2015, ADV WOUND CARE, V4, P75, DOI 10.1089/wound.2014.0575
   Payne Caroline, 2014, Eplasty, V14, pe20
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NR 22
TC 6
Z9 7
U1 0
U2 11
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2021
VL 30
IS 12
BP 1006
EP 1010
DI 10.12968/jowc.2021.30.12.1006
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA XN8PR
UT WOS:000729761400007
PM 34882000
DA 2026-07-24
ER
PT J
AU Borejsza-Wysocki, M
   Bobkiewicz, A
   Francuzik, W
   Krokowicz, L
   Walczak, D
   Szmeja, J
   Banasiewicz, T
AF Borejsza-Wysocki, Maciej
   Bobkiewicz, Adam
   Francuzik, Wojciech
   Krokowicz, Lukasz
   Walczak, Dominik
   Szmeja, Jacek
   Banasiewicz, Tomasz
TI Effect of closed incision negative pressure wound therapy on incidence
   rate of surgical site infection after stoma reversal: a pilot study
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Article
DE closed incision negative pressure wound therapy; stoma reversal;
   surgical site infection
ID VACUUM-ASSISTED CLOSURE; ILEOSTOMY CLOSURE; SKIN CLOSURE; PROTECTIVE
   ILEOSTOMY; PURSESTRING CLOSURE; MANAGEMENT-SYSTEM; RISK; PREVENTION;
   COMPLICATIONS; COLOSTOMY
AB Introduction: The stoma reversal (SR) procedure is associated with a relatively high risk of perioperative complications with surgical site infection (SSI) as the most common. Recently closed incision negative pressure wound therapy (ciNPWT) was applied widely to prevent SSI. Aim: To investigate the efficiency of ciNPWT in terms of the incidence rate of SSI after SR surgery. Material and methods: As an exploratory observational cohort study patients were treated either with ciNPWT (n = 15) or standard sterile dressing (SSD) (n = 15). CiNPWT was applied every 3 days whereas SSD was changed every day. Clinical evaluation for SSI signs, C-reactive protein level and pain assessment using the visual analogue scale (VAS) were analyzed. Results: The incidence rate of SSI was in 13% (2/15) in the ciNPWT group and 26% (4/15) in the SSD group (p = 0.651, OR = 0.44, 95% CI: 0.03-3.73). All patients in the SSD group who developed SSI presented both local and generalized signs of infection. Pain-VAS levels assessed on the 1st (MdnciNPWT = 4, MdnSSD = 5, p = 0.027, W = 51.5) and 3rd postoperative day (MdnciNPWT = 2, MdnSSD = 4, p = 0.014, W = 45.5) were significantly lower in the ciNPWT group than in the SSD group. Conclusions: CiNPWT seems not to have a benefit to reduce SSI after the SR procedure. Further investigation is needed to establish firmly the benefit of using ciNPWT in this group of patients.
C1 [Borejsza-Wysocki, Maciej; Bobkiewicz, Adam; Krokowicz, Lukasz; Szmeja, Jacek; Banasiewicz, Tomasz] Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, Poznan, Poland.
   [Francuzik, Wojciech] Charite, Dept Dermatol Venerol & Allergol, Berlin, Germany.
   [Walczak, Dominik] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Ontol & Reconstruct Surg, Gliwice, Poland.
C3 Poznan University of Medical Sciences; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin
RP Bobkiewicz, A (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, Poznan, Poland.
EM bobofon007@gmail.com
RI Francuzik, Wojciech/H-6773-2019
OI Francuzik, Wojciech/0000-0001-5361-9876
CR Bergquist JR, 2016, J AM COLL SURGEONS, V222, P431, DOI 10.1016/j.jamcollsurg.2015.12.034
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   Bobkiewicz A, 2017, INT WOUND J, V14, P255, DOI 10.1111/iwj.12597
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NR 49
TC 18
Z9 20
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2021
VL 16
IS 4
BP 686
EP 696
DI 10.5114/wiitm.2021.106426
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XN9JW
UT WOS:000729814600007
PM 34950263
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhang, H
   Wang, SY
   Lei, C
   Li, GM
   Wang, B
AF Zhang, Hong
   Wang, Songyu
   Lei, Chen
   Li, Guanmin
   Wang, Biao
TI Experimental study of negative pressure wound therapy combined with
   platelet-rich fibrin for bone-exposed wounds
SO REGENERATIVE MEDICINE
LA English
DT Article
DE bone exposure; collagen formation; combination strategy; granulation
   tissue; growth factors; negative pressure wound therapy; platelet-rich
   fibrin; regenerative therapy; vacuum sealing drainage; wound healing
ID VACUUM-ASSISTED CLOSURE; CELL-MIGRATION; GROWTH-FACTOR; MECHANISM; PRF;
   PROLIFERATION; FIBRONECTIN; EXPRESSION
AB Aim: To evaluate the efficacy of negative pressure wound therapy (NPWT) combined with platelet-rich fibrin (PRF) in treating bone-exposed wounds and explore its possible mechanism. Materials & methods: A bone-exposed wound was created in a total of 32 healthy Sprague-Dawley rats, which were treated with either control, NPWT group, PRF group or both (N + P group). The bone-exposed area, skin contraction rate and granulation coverage and the level of growth factors in granulation tissue were determined on days 4, 7 and 10. Results: The N + P group showed significantly higher wound closure rate than that achieved with others respectively. Four factors were significantly higher in N + P group than in the other three groups. Conclusion: Combination of NPWT and PRF can repair bone-exposed wounds effectively and accelerate wound healing.
   Lay abstract Wounds with exposed bone are refractory, and are usually caused by mechanical trauma, burns, infections, pressure ulcers, diabetic illness and tumor resection. Surgery is the most effective way to cover such wounds. However, repairing defects with local or distal skin flaps can cause potential donor site damage. Skin grafting might be a simpler method, but the avascular interface of bone makes granulation tissue difficult to grow, thus transplanting skin on exposed bones is contraindicated. There is growing interest in identifying alternative treatment strategies. In this study, our goal is to use platelet-derived fibrin in combination with negative pressure wound therapy to determine whether this combined strategy can achieve mesenchymal healing with granulation tissue to treat bone exposed wounds. The results of wound healing in the negative pressure wound therapy and platelet-rich fibrin combined treatment group were better than those of other treatment groups. The combined treatment strategy of platelet-derived fibrin and negative pressure wound therapy can repair bone-exposed wounds effectively, accelerate wound healing and is a promising therapeutic option for bone exposed wounds.
C1 [Zhang, Hong; Wang, Songyu; Lei, Chen; Li, Guanmin; Wang, Biao] Fujian Med Univ, Affiliated Hosp 1, Dept Plast & Cosmet Surg, Fuzhou 350000, Fujian, Peoples R China.
   [Zhang, Hong] Fujian Childrens Hosp, Dept Pediat Surg, Fuzhou 350000, Fujian, Peoples R China.
   [Zhang, Hong] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Fujian Branch, Fuzhou 350000, Fujian, Peoples R China.
   [Zhang, Hong] Fujian Med Univ, Affiliated Hosp, Fujian Matern & Child Hlth Hosp, Fuzhou 350000, Fujian, Peoples R China.
C3 Fujian Medical University; Shanghai Jiao Tong University; Fujian Medical
   University
RP Wang, B (通讯作者)，Fujian Med Univ, Affiliated Hosp 1, Dept Plast & Cosmet Surg, Fuzhou 350000, Fujian, Peoples R China.
EM 1812166371@qq.com
RI Zhang, Hong/HTO-0968-2023
OI Zhang, Hong/0000-0002-5866-8674
FU Scientific Research Foundation of National Health Planning Scientific
   Research FoundationJoint Research Projects of Fujian Provincial Health
   and Education [2019-WJ-09]; Young and Middle-aged Key Personnel Training
   Project of Fujian Provincial Health Commission [2020GGB029]; National
   Natural Science Foundation of China [81801931]
FX This work was supported by the the Scientific Research Foundation of
   National Health Planning Scientific Research FoundationJoint Research
   Projects of Fujian Provincial Health and Education (2019-WJ-09); Young
   and Middle-aged Key Personnel Training Project of Fujian Provincial
   Health Commission (2020GGB029); and National Natural Science Foundation
   of China (no. 81801931). The authors have no other relevant affiliations
   or financial involvement with any organization or entity with a
   financial interest in or financial conflict with the subject matter or
   materials discussed in the manuscript apart from those disclosed.
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NR 55
TC 10
Z9 10
U1 0
U2 14
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1746-0751
EI 1746-076X
J9 REGEN MED
JI Regen. Med.
PD JAN
PY 2022
VL 17
IS 1
BP 23
EP 35
DI 10.2217/rme-2021-0043
EA DEC 2021
PG 13
WC Cell & Tissue Engineering; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA XP3GK
UT WOS:000730155100001
PM 34905932
OA hybrid
DA 2026-07-24
ER
PT J
AU Turcotte, JJ
   Boord, A
   Antognoli, L
   Klune, JR
   Feather, CB
AF Turcotte, Justin J.
   Boord, Andrea
   Antognoli, Lauren
   Klune, J. Robert
   Feather, Cristina B.
TI Does Wound Management Technique Impact Surgical Site Infection in Open
   Emergency Colon Procedures?
SO AMERICAN SURGEON
LA English
DT Article
DE surgical site infection; wound closure; emergency colorectal surgery
ID COLORECTAL SURGERY; RISK-FACTORS; METAANALYSIS
AB Background Emergency open large bowel procedures have higher rates of intraoperative contamination and increased risk of surgical site infection (SSI) than elective colon surgeries. Several wound management strategies have been proposed, such as vacuum-assisted closure (VAC) therapy and delayed primary closure to improve results. The purpose of this study is to evaluate the relationship between wound management technique and SSI and other quality measures. Methods We performed a retrospective review of patients undergoing open emergency colon surgery from January 2017 to December 2018 by our acute care surgery service. The primary outcome measure was incidence of SSI. Secondary outcome measures included length of stay, reoperation, and 30-day readmission. Results A total of 118 patients were included in the study, with a mean age of 62.8 years and mean BMI of 28.8. Overall incidence of SSI was 19.5%. There was no significant difference in incidence of SSI, reoperation, or 30-day readmission when stratifying by wound management technique or procedure type after controlling for confounding variables. Notably, patients managed with VAC therapy had a statistically significant longer average length of stay and higher total postoperative antibiotic days (both P = .001) than other techniques. Discussion We conclude from our data that wound management technique does not seem to influence rate of SSI, but wound management may influence length of stay or antibiotic duration. These findings suggest that there may not be an advantage to alternative methods of wound management in this high-risk population. Further prospective evaluation should be performed to confirm these findings.
C1 [Turcotte, Justin J.; Boord, Andrea; Antognoli, Lauren; Klune, J. Robert; Feather, Cristina B.] Anne Arundel Med Ctr, Dept Surg, 2001 MED PKWY, Annapolis, MD 21401 USA.
RP Feather, CB (通讯作者)，Anne Arundel Med Ctr, Dept Surg, 2001 MED PKWY, Annapolis, MD 21401 USA.
EM cfeather@aahs.org
RI Feather, Cristina/AAA-3705-2022
OI Boord, Anea/0000-0002-8988-4054
CR Alkaaki A, 2019, CAN J SURG, V62, P111, DOI 10.1503/cjs.004818
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   Healthcare JCCfT, 2020, SURG SITE INFECT
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NR 13
TC 2
Z9 3
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JAN
PY 2022
VL 88
IS 1
BP 140
EP 145
DI 10.1177/0003134820982565
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XP2QO
UT WOS:000730715700020
PM 33382343
DA 2026-07-24
ER
PT J
AU Guo, CC
   Cheng, T
   Li, JS
AF Guo, Chenchen
   Cheng, Tao
   Li, Junsheng
TI Prophylactic negative pressure wound therapy on surgical site infection
   in obese women after cesarean section: A systematic review and
   meta-analysis
SO INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
LA English
DT Review
DE cesarean section; negative pressure wound therapy; obesity; surgical
   site infection; wound complications
ID DELIVERY; RISK; TRIAL
AB Prevention of surgical site infection (SSI) is a public health challenge. The objective of the study was to evaluate the efficacy of negative pressure wound therapy (NPWT) for preventing SSI and other wound complications in obese women undergoing cesarean section. The search terms included "negative pressure wound therapy", "obesity" and "cesarean section/delivery". Randomized controlled trials were used to compare the use of NPWT to standard dressings in preventing SSI in obese women after cesarean section. A comprehensive literature search of four databases was performed up to June 2021. The primary outcome was SSI. Secondary outcomes were seroma, hematoma, overall wound complications, and adverse skin reactions. Ten RCTs involving 5586 patients met the inclusion criteria. The use of NPWT reduced SSI (RR = 0.76, 95%CI: 0.63-0.92, P = 0.004). No statistically significant difference was detected in the incidence of overall wound complications (RR = 0.93, P = 0.48), seroma (RR = 1.10, P = 0.79), hematoma (RR = 0.63, P = 0.36) and hospital readmission (RR = 1.41, P = 0.15). NPWT significantly increased the occurrence of skin blistering with a RR of 4.60 (P = 0.04). Use of prophylactic NPWT after cesarean delivery among obese women is associated with a significant reduction of surgical site infection.
C1 [Guo, Chenchen] Southeast Univ, Sch Med, Nanjing, Peoples R China.
   [Cheng, Tao; Li, Junsheng] Southeast Univ, Affiliated Zhongda Hosp, Dept Gen Surg, Nanjing 210009, Peoples R China.
C3 Southeast University - China; Southeast University - China
RP Li, JS (通讯作者)，Southeast Univ, Affiliated Zhongda Hosp, Dept Gen Surg, Nanjing 210009, Peoples R China.
EM lijunshenghd@126.com
RI Li, Junsheng/E-4990-2013
OI Guo, Chenchen/0000-0003-3182-8671
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NR 32
TC 9
Z9 11
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7292
EI 1879-3479
J9 INT J GYNECOL OBSTET
JI Int. J. Gynecol. Obstet.
PD SEP
PY 2022
VL 158
IS 3
BP 502
EP 511
DI 10.1002/ijgo.14058
EA DEC 2021
PG 10
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 3R2NM
UT WOS:000731212700001
PM 34860421
DA 2026-07-24
ER
PT J
AU Hu, CW
   Chang, TNJ
   Chen, YC
   Hu, CH
AF Hu, Ching-Wei
   Chang, Tommy Nai-Jen
   Chen, Yi-Chieh
   Hu, Ching-Hsuan
TI Negative-Pressure Wound Therapy Application in Fingertip Replantations
   and a Systematic Review
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT Plastic Surgery The Meeting / Annual Meeting of the
   American-Society-of-Plastic-Surgeons (ASPS)
CY OCT 06-10, 2017
CL Orlando, FL
SP Amer Soc Plast Surg
ID VENOUS ANASTOMOSIS; FREE-FLAP; ARTERIOVENOUS ANASTOMOSIS; CONGESTION;
   DRAINAGE; SURVIVAL; ARTERY; SALVAGE
AB Background: Fingertip replantation is technically challenging. Venous congestion is one of the most common causes of replantation failure. Therefore, various venous drainage procedures and salvage techniques have been used in venous congestion. Negative-pressure wound therapy has proven beneficial in limb injuries, yet limited studies of fingertip replantation exist. This study aims to analyze risk factors in fingertip replantation and to evaluate the feasibility and clinical benefits of negative-pressure wound therapy compared with other salvage techniques.
   Methods: From January of 2015 to December of 2019, 27 patients (27 digits) who experienced fingertip amputation over Tamai zone I or II underwent replantation. Salvage negative-pressure wound therapy was applied for venous congestion postoperatively. Replantation data were collected for further analysis.
   Results: The overall survival rate of digit replantation with salvage negative-pressure wound therapy was 92.6 percent (25 of 27). The blood transfusion rate was 11.1 percent (three of 27). The average hospitalization time was 8.04 +/- 1.43 days and the median duration of negative-pressure wound therapy was 6 days (range, 4 to 8 days; interquartile range, 2 days). There is no significant difference between the survival and failure groups for all risk factors evaluated.
   Conclusion: Negative-pressure wound therapy is a simple and effective salvage option to relieve venous congestion in fingertip replantation with a satisfactory survival rate, low blood transfusion rate, and short inpatient stay.
C1 Chang Gung Univ, Chang Gung Mem Hosp, Chang Gung Med Coll, Dept Plast & Reconstruct Surg, Taoyuan, Taiwan.
   Chang Gung Univ, Taoyuan, Taiwan.
   Chicing Plast Surg Clin, Taipei, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung
   University
RP Hu, CH (通讯作者)，Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, 5 Fuxing St, Taoyuan 333, Taiwan.
EM chinghsuanhu@hotmail.com.tw
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NR 38
TC 6
Z9 7
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2022
VL 149
IS 1
BP 38E
EP 47E
DI 10.1097/PRS.0000000000008628
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA XS4GV
UT WOS:000732870600010
PM 34936614
DA 2026-07-24
ER
PT J
AU Tuñon, C
   De Lucas, J
   Cubilla, J
   Andrade, R
   Aguirre, M
   Cisneros, JZ
AF Tunon, Carlos
   De Lucas, Juan
   Cubilla, Jan
   Andrade, Rafael
   Aguirre, Miguel
   Cisneros, Julio Zuniga
TI Endoluminal vacuum therapy in the management of an esophago-pleural
   fistula as a complication of Boerhaave syndrome in a patient with
   eosinophilic esophagitis
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Boerhaave syndrome; Eosinophilic esophagitis; Vacuum-assisted closure;
   Endoscopy; Case report
ID PERFORATIONS
AB Background Boerhaave syndrome is an uncommon condition that represents about 15% of all esophageal perforation. A subset of these patients has eosinophilic esophagitis, a chronic inflammatory disease of the esophagus, that carries a risk of perforation of about 2%. Esophageal perforations can rarely result in the development of an esophago-pleural fistula. Treatment of esophago-pleural fistula represent a challenge due to lack of high quality evidence and scarce reported experience. Endoluminal vacuum-assisted therapy could have a role in the management by using the same principle applied in external wounds which provide wound drainage and tissue granulation. Case presentation We report a unique case of a 24-year-old man with eosinophilic esophagitis complicated with an esophageal rupture who developed an esophago-pleural fistula and was successfully managed with a non-surgical approach using endoluminal vacuum-assisted therapy. To our knowledge this could be the first experience reported in a patient with eosinophilic esophagitis. Conclusion Endoluminal vacuum-assisted therapy might be an effective and novel strategy in patients with eosinophilic esophagitis and esophago-pleural fistula as a consequence of Boerhaave syndrome. Appropriately designed studies are required.
C1 [Tunon, Carlos; De Lucas, Juan; Cubilla, Jan] Santo Tomas Hosp, Dept Gastroenterol, Panama City, Panama.
   [Andrade, Rafael; Aguirre, Miguel] Santo Tomas Hosp, Dept Thorac Surg, Panama City, Panama.
   [Cisneros, Julio Zuniga] Santo Tomas Hosp, Dept Internal Med, Panama City, Panama.
RP Cisneros, JZ (通讯作者)，Santo Tomas Hosp, Dept Internal Med, Panama City, Panama.
EM juliozc22@gmail.com
OI Cubilla Rodríguez, Jan Axel/0000-0002-5201-7344; Zúñiga Cisneros,
   Julio/0000-0002-4659-3468
CR Heits N, 2014, ANN THORAC SURG, V97, P1029, DOI 10.1016/j.athoracsur.2013.11.014
   de Moura DTH, 2019, WORLD J GASTRO ENDOS, V11, P329, DOI 10.4253/wjge.v11.i5.329
   Kaman L, 2011, GASTROENTEROLOGY RES, V6, P66
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NR 11
TC 4
Z9 6
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD DEC 20
PY 2021
VL 21
IS 1
AR 484
DI 10.1186/s12876-021-02058-z
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA XS5LO
UT WOS:000732950500009
PM 34930127
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wolfsberger, CH
   Maitz, E
   Schmachtl, P
   Winkler, S
   Luschnig, D
   Sigl, E
   Heinzle, A
   Gamerith, C
   Tuca, AC
   Schintler, MV
AF Wolfsberger, Christina Helene
   Maitz, Emanuel
   Schmachtl, Philipp
   Winkler, Sonja
   Luschnig, Daniel
   Sigl, Eva
   Heinzle, Andrea
   Gamerith, Clemens
   Tuca, Alexandru-Cristian
   Schintler, Michael V.
TI Feasibility of collecting wound fluid during ongoing negative pressure
   wound therapy by the use of an additional container - A prospective
   observational study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE diagnostic tool; negative pressure wound therapy; vacuum-assisted
   closure; wound care; wounds
ID VACUUM-ASSISTED CLOSURE
AB Negative-pressure-wound-therapy is commonly used in clinical routine for wound management. Aim of the present study was to assess the feasibility and safety of using an additional container to collect wound fluid during ongoing negative-pressure-wound-therapy. In this present prospective observational study, patients with negative-pressure-wound-therapy were included. An additional container was inserted in the connecting tube between the wound and the vacuum generating device. The following 3 days, the container was changed daily and replaced by a new one. Further safety outcome parameters were assessed. A questionnaire was answered by the responsible surgeon. Twenty-two patients with negative-pressure-wound-therapy with a median (IQR) age of 58.5 (53.0-70.0) years were included in the present study. In median, the duration of negative-pressure-wound-therapy was 5.0 (4.6-5.5) days. In mean +/- SD the collected volume of the wound fluid in millilitres (mL) was on day one 7 +/- 4 on day two 8 +/- 7 and 10 +/- 11 on day three. In one patient, there was <0.1 mL of clear water in the additional container. No safety concerns due to the additional container were observed. This study demonstrates that collecting wound fluid during ongoing negative-pressure-wound-therapy over a time period of 3 days is feasible and safe. No safety concerns were observed.
C1 [Wolfsberger, Christina Helene] Med Univ Graz, Div Neonatol, Dept Pediat & Adolescent Med, Auenbruggerpl 34-2, A-8036 Graz, Austria.
   [Maitz, Emanuel] Med Univ Graz, Div Gen Otorhinolaryngol, Dept Otorhinolaryngol, Graz, Austria.
   [Winkler, Sonja; Luschnig, Daniel; Sigl, Eva; Heinzle, Andrea; Gamerith, Clemens] Qualizyme Diagnost GmbH Co KG, Graz, Austria.
   [Wolfsberger, Christina Helene; Tuca, Alexandru-Cristian; Schintler, Michael V.] Med Univ Graz, Div Plast Aesthet & Reconstruct Med, Dept Surg, Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; Medical
   University of Graz
RP Wolfsberger, CH (通讯作者)，Med Univ Graz, Div Neonatol, Dept Pediat & Adolescent Med, Auenbruggerpl 34-2, A-8036 Graz, Austria.
EM christina.wolfsberger@medunigraz.at
RI ; Heinzle, Andrea/GWB-9749-2022
OI Wolfsberger, Christina Helene/0000-0002-9770-3487; Gamerith,
   Clemens/0000-0001-8271-1700; 
FU Qualizyme Diagnostics GmbH Co KG, Austria
FX Qualizyme Diagnostics GmbH & Co KG, Austria
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NR 19
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2022
VL 19
IS 5
BP 1133
EP 1140
DI 10.1111/iwj.13709
EA DEC 2021
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 2X8AB
UT WOS:000733309100001
PM 34939308
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, ZW
   Wang, XJ
   Zhang, KY
   Xian, HY
AF Wang, Zhuo Wei
   Wang, Xue Jiu
   Zhang, K. Y.
   Xian, H. Y.
TI Correlation between p16 and Interleukin-2 Gene Expression and Oral and
   Maxillofacial Wound Healing
SO INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Oral and maxillofacial trauma; p16; interleukin-2; trauma healing
ID INFECTIONS; IL-2
AB To analyze the relationship between p16 and interleukin-2 protein and messenger RNA levels and wound healing in patients with oral and maxillofacial trauma. 86 patients with oral and maxillofacial trauma were selected in our hospital from June 2018 to June 2020 and divided into good and poor trauma healing group. All patients were treated with vacuum sealing drainage and given empirical antibacterial anti-infective medication, nutritional support and correction of fluid-electrolyte disturbances for 7 d. Serum levels of inflammatory factors were measured before and after 7 d of treatment. The levels of interleukin-2, p16 and messenger RNA were measured by western blot and polymerase chain reaction. White blood cells, tumor necrosis factor alpha, interleukin-6, C-reactive protein and procalcitonin were lower in both groups than before treatment while the phosphorylated form of p16/p16, phosphorylated form of interleukin-2/interleukin-2 proteins and messenger RNA levels were lower immediately after extubation (p<0.05). Pearson correlation analysis revealed that phosphorylated form of p16/p16 and phosphorylated form of interleukin-2/interleukin-2 were significantly lower in the group immediately after extubation (p<0.05). Phosphorylated form of p16/p16 and phosphorylated form of interleukin-2/interleukin-2 were positively correlated with white blood cells, tumor necrosis factor alpha, interleukin-6, C-reactive protein and procalcitonin after treatment (p<0.001). It is concluded that p16 and interleukin-2 in the drainage fluid of patients with oral and maxillofacial trauma can promote the process of wound healing by promoting the release of serum inflammatory factors.
C1 [Wang, Zhuo Wei] Beijing Tradit Chinese Med Hosp, Shunyi Hosp, Dept Stomatol, Beijing 101300, Peoples R China.
   [Wang, Xue Jiu; Zhang, K. Y.] Beijing Stomatol Hosp, Dept Maxillofacial Trauma Orthognath Surg, Beijing 100050, Peoples R China.
   [Xian, H. Y.] Beijing Shunyi Hosp, Dept Ophthalmol, Beijing 101300, Peoples R China.
C3 Capital Medical University
RP Wang, ZW (通讯作者)，Beijing Tradit Chinese Med Hosp, Shunyi Hosp, Dept Stomatol, Beijing 101300, Peoples R China.
EM syyykq@163.com
FU Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital
FX This work was supported by the Shunyi Hospital, Beijing Traditional
   Chinese Medicine Hospital.
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NR 23
TC 0
Z9 0
U1 0
U2 1
PU INDIAN PHARMACEUTICAL ASSOC
PI MUMBAI
PA KALINA, SANTA CRUZ EAST, MUMBAI, 00000, INDIA
SN 0250-474X
EI 1998-3743
J9 INDIAN J PHARM SCI
JI Indian J. Pharm. Sci.
PY 2021
VL 83
SI 5
BP 169
EP 176
DI 10.36468/pharmaceutical-sciences.spl.348
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XT8QK
UT WOS:000733845400026
OA gold
DA 2026-07-24
ER
PT J
AU Shestak, KC
AF Shestak, Kenneth C.
TI The Internal Negative-Pressure Wound Control System: A Paradigm Shift
   for Promoting Deep Space Healing in Complex Surgically Created Wounds
SO AESTHETIC SURGERY JOURNAL
LA English
DT Article
ID PROGRESSIVE TENSION SUTURES; VACUUM-ASSISTED CLOSURE; ABDOMINAL-WALL;
   SEROMA; ABDOMINOPLASTY; THERAPY; PREVENTION; SURGERY
AB This article introduces a new technology to minimize seroma and promote more predictable healing in surgically created deep space wounds. Its novel design internalizes the delivery of a continuously generated high negative pressure (-125 mmHg) throughout the surgically created space by means of a multibranched Manifold. In a small prospective cohort case study of 24 patients undergoing full abdominoplasty, all patients underwent placement of this device, which was removed 7 days postoperatively. Results at 30 days revealed no evidence of wound-healing problems, no clinical seroma, and no device malfunction. The internalization of a constant negative-pressure wound therapy provided by this system has the potential to significantly reduce clinical seroma, and to produce more consistent apposition of interfaces in deep tissue spaces in complex wounds seen in plastic surgery and other surgical disciplines.
C1 [Shestak, Kenneth C.] Univ Pittsburgh UPMC, Dept Plast Surg, Plast Surg, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Pittsburgh Medical Center
RP Shestak, KC (通讯作者)，Univ Pittsburgh, UPMC Aesthet Surg Ctr, Dept Plast Surg, Sch Med, 3380 Blvd Allies,Suite 180, Pittsburgh, PA 15213 USA.
EM shestakkc@upmc.edu
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   Shermak MA, 2008, PLAST RECONSTR SURG, V122, P280, DOI 10.1097/PRS.0b013e31817742a9
   Shestak KC, 2019, AESTHET SURG J, V39, P628, DOI 10.1093/asj/sjy215
   Shin SJ, 2014, J CRANIOFAC SURG, V25, P1427, DOI 10.1097/SCS.0000000000000575
   Singh D, 2019, PLAST RECONSTR SURG, V143, p11S, DOI 10.1097/PRS.0000000000005306
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NR 28
TC 1
Z9 1
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1090-820X
EI 1527-330X
J9 AESTHET SURG J
JI Aesthet. Surg. J.
PD NOV
PY 2021
VL 41
IS 11
BP NP1543
EP NP1549
DI 10.1093/asj/sjab307
EA AUG 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XU3OB
UT WOS:000734177600051
PM 34347042
DA 2026-07-24
ER
PT J
AU Rother, U
   Theune, M
   Lang, W
   Meyer, A
AF Rother, Ulrich
   Theune, Mona
   Lang, Werner
   Meyer, Alexander
TI Pilot assessment of the effect of negative pressure wound therapy on
   microperfusion of chronic and acute wounds
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Negative pressure therapy; microperfusion; CLTI; fasciotomy; O2C
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; LASER-DOPPLER; TISSUE
   OXYGENATION; PERFUSION; WALL
AB BACKGROUND: Negative pressure wound therapy (NPWT) has been established over years for treatment of chronic and complex wounds.
   OBJECTIVE: Aim of this study was to investigate the effect NPWT on the microperfusion.
   METHODS: Prospective single centre analysis of patients treated with NPWT due to acute (ACUTE) wounds after fasciotomy or patients with chronic wounds (CHRONIC) due to a chronic limb threatening ischemia was performed. NPWT was conducted through a three days sequence with a negative pressure of -120 mmHg. Before after and during the entire period of therapy the microperfusion was assessed (O2C (TM), LEA Medizintechnik).
   RESULTS: Comparison of the perfusion values of 28 patients (CHRONIC/ACUTE 5/23, women/men 8/20) before and after the NPWT sequence showed a non-significant improvement in the CHRONIC group (supine position: p = 0.144, elevated position p = 0.068) and a significant decrease in the ACUTE group (supine position p = 0.012, elevated position p = 0.034). This effect could also been demonstrated during the NPWT over time (CHRONIC: supine position: p =0 .320 , elevated position: p = 0.053, ACUTE: supine position: p = 0.021, elevated position: p = 0.012).
   CONCLUSION: Microperfusion measurements showed alterations and differences in wound bed perfusion of acute and chronic wounds; acute wounds tended to a decrease of blood flow, whereas this effect was not seen in chronic wounds in peripheral artery disease.
C1 [Rother, Ulrich; Theune, Mona; Lang, Werner; Meyer, Alexander] Friedrich Alexander Univ Erlangen Nuremberg, Dept Vasc Surg, Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Rother, U (通讯作者)，Friedrich Alexander Univ Erlangen Nuremberg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM ulrich.rother@uk-erlangen.de
RI Rother, Ulrich/LGZ-9441-2024
CR Almeida JE, 2018, J WOUND CARE, V27, pS28, DOI 10.12968/jowc.2018.27.Sup2.S28
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   Atkins BZ, 2011, INT WOUND J, V8, P56, DOI 10.1111/j.1742-481X.2010.00743.x
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NR 28
TC 1
Z9 3
U1 0
U2 2
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2021
VL 79
IS 3
BP 455
EP 462
DI 10.3233/CH-211189
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA XU5JY
UT WOS:000734302100009
PM 34057141
DA 2026-07-24
ER
PT J
AU Luo, BJ
   Zhang, HQ
   Zhong, JD
   He, XZ
   Shen, F
   Zheng, MC
   Wen, YS
   Li, JB
   Xin, MZ
AF Luo, Bao-Jia
   Zhang, Hui-Qin
   Zhong, Jiu-Di
   He, Xiang-Zi
   Shen, Fang
   Zheng, Mei-Chun
   Wen, Yong-Shan
   Li, Jin-Bo
   Xin, Ming-Zhu
TI A randomized trial of negative pressure wound therapy technology
   combined with intermittent instillation in the treatment of neck
   anastomotic leakage after esophageal cancer surgery
SO JOURNAL OF GASTROINTESTINAL ONCOLOGY
LA English
DT Article
DE Neck anastomotic fistula; negative pressure wound therapy combined with
   intermittent instillation; nursing
AB Background: This study aimed to examine the effects of applying the negative pressure wound therapy (NPWT) combined with intermittent instillation (NPWTi) in patients with cervical anastomotic leakage (AL) after esophageal cancer surgery.
   Methods: From July 2019 to June 2021, 64 patients undergoing AL after esophageal cancer surgery were selected from our Hospital's Thoracic Department, and randomly allocated to the conventional nursing group (20 patients), the hospital central NPWTi group (23 patients), and the portable NPWTi group (21 patients). The hospital central NPWTi group was treated with central negative pressure combined with intermittent instillation, and the portable NPWTi group was treated with portable negative pressure combined with intermittent instillation. Indicators of fistula healing, healing days, treatment costs, comfort, and nursing satisfaction were examined in each group.
   Results: The fistula healing rate, healing days, nursing satisfaction, and comfort level of the hospital central NPWTi group and the portable NPWTi group were better than those of the conventional nursing group (P<0.05). There was no difference in the fistula healing rates and healing days between the hospital central NPWTi group, and the portable NPWTi group (P>0.05). The treatment costs of the hospital central NPWTi group were lower than those of the portable NPWTi group (P<0.05).
   Conclusions: Negative pressure treatment technology combined with the intermittent instillation of the neck anastomotic fistula improved the fistula microenvironment, strengthened the sterilization effect, drained the leachate effectively, shortened the fistula healing time, improved the fistula cure rate, and increased patients' satisfaction with nursing. In relation to the negative pressure source, there was no difference in the therapeutic effects of hospital central NPWTi compared to the portable negative pressure meter, but the hospital central NPWTi treatment costs were lower and patients' acceptance of NPWT instillation was higher. "Thus, central NPWT instillation treatment is worthy of promotion.
C1 [Luo, Bao-Jia; Zhang, Hui-Qin; Zheng, Mei-Chun; Wen, Yong-Shan] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Colorectal Surg Dept, State Key Lab Oncol South China, Guangzhou, Peoples R China.
   [Zhong, Jiu-Di; Li, Jin-Bo] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Thorac Surg Dept, State Key Lab Oncol South China, Guangzhou, Peoples R China.
   [He, Xiang-Zi] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Tradit Chinese Med & VIP Reg, Guangzhou, Peoples R China.
   [Shen, Fang] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Gastr Surg Dept, State Key Lab Oncol South China, Guangzhou, Peoples R China.
   [Xin, Ming-Zhu] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Nursing Dept, State Key Lab Oncol South China, Guangzhou, Peoples R China.
C3 Sun Yat Sen University; State Key Lab Oncology South China; State Key
   Lab Oncology South China; Sun Yat Sen University; Sun Yat Sen
   University; State Key Lab Oncology South China; Sun Yat Sen University;
   State Key Lab Oncology South China; Sun Yat Sen University; State Key
   Lab Oncology South China
RP Xin, MZ (通讯作者)，Sun Yat Sen Univ Canc Ctr, 651 Dong Feng Rd East, Guangzhou, Peoples R China.
EM xinmzh@sysucc.org.cn
RI Li, Jinbo/AAF-1566-2019
FU Guangdong Provincial Medical, Science and Technology Research Project
   [A2019239]
FX We received funding from the Guangdong Provincial Medical, Science and
   Technology Research Project 2019 (A2019239).
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NR 28
TC 4
Z9 4
U1 0
U2 16
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2078-6891
EI 2219-679X
J9 J GASTROINTEST ONCOL
JI J. Gastrointest. Oncol.
PD DEC
PY 2021
VL 12
IS 6
BP 2665
EP 2674
DI 10.21037/jgo-21-605
EA NOV 2021
PG 10
WC Oncology; Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Gastroenterology & Hepatology
GA YT9CM
UT WOS:000734912000001
PM 35070396
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Meyer, J
   Roos, E
   Abbassi, Z
   Buchs, NC
   Ris, F
   Toso, C
AF Meyer, Jeremy
   Roos, Elin
   Abbassi, Ziad
   Buchs, Nicolas C.
   Ris, Frederic
   Toso, Christian
TI Prophylactic Negative-pressure Wound Therapy Prevents Surgical Site
   Infection in Abdominal Surgery: An Updated Systematic Review and
   Meta-analysis of Randomized Controlled Trials and Observational Studies
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
DE PREVENA; PICO; NPWT; SSI; surgical site infection; pNPWT
ID LAPAROTOMY INCISIONS; OUTCOMES; IMPACT; COSTS
AB Background. Prevention of surgical site infection (SSI) is a public health challenge. Our objective was to determine if prophylactic negative-pressure wound therapy (pNPWT) allows preventing SSI after laparotomy.
   Methods. Medline, Embase, and Web of Science were searched on 6 October 2019 for original studies reporting the incidences of SSI in patients undergoing open abdominal surgery with and without pNPWT. Risk differences (RDs) between control and pNPWT patients and risk ratios (RRs) for SSI were obtained using random-effects models.
   Results. Twenty-one studies (2930 patients, 5 randomized controlled trials [RCTs], 16 observational studies) were retained for the analysis. Pooled RD between patients with and without pNPWT was -12% (95% confidence interval [CI], -17% to -8%; I-2 = 57%; P < .00001) in favor of pNPWT. That risk difference was -12% (95% CI, -22% to -1%; I-2 = 69%; P = .03) when pooling only RCTs (792 patients). pNPWT was protective against the incidence of SSI with a RR of 0.53 (95% CI,.40-.71; I-2 = 56%; P < .0001). The effect on pNPWT was more pronounced in studies with an incidence of SSI >= 20% in the control arm. The preventive effect of pNPWT on SSI remained after correction for potential publication bias. However, when pooling only high-quality observational studies (642 patients) or RCTs (527 patients), significance was lost.
   Conclusions. Existing studies suggest that pNPWT on closed wounds is protective against the occurrence of SSI in abdominal surgery, but these findings need to be confirmed by more high-quality evidence, preferentially in subgroups of patients with an incidence of SSI >= 20% in the control arm.
C1 [Meyer, Jeremy; Abbassi, Ziad; Buchs, Nicolas C.; Ris, Frederic; Toso, Christian] Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Meyer, Jeremy; Abbassi, Ziad; Buchs, Nicolas C.; Ris, Frederic; Toso, Christian] Univ Geneva, Unit Surg Res, Geneva, Switzerland.
   [Roos, Elin] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
C3 University of Geneva; University of Geneva; Karolinska Institutet
RP Meyer, J (通讯作者)，Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM jeremy.meyer@hcuge.ch
RI Abbassi, Ziad/HZL-6239-2023; Meyer, Jeremy/AAP-3367-2020; Toso,
   Christian/E-7785-2018; Ris, Frederic/H-7030-2019
OI Abbassi, Ziad/0000-0002-4130-5084; Meyer, Jeremy/0000-0003-3381-9146;
   Toso, Christian/0000-0003-1652-4522; Ris, Frederic/0000-0001-7421-6101
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NR 46
TC 26
Z9 28
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD DEC 1
PY 2021
VL 73
IS 11
BP E3804
EP E3813
DI 10.1093/cid/ciaa1203
PG 10
WC Immunology; Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Microbiology
GA XW0GU
UT WOS:000735309500029
PM 32818259
OA Green Accepted, Bronze
DA 2026-07-24
ER
PT J
AU Kojima, K
   Goto, M
   Nagashima, Y
   Saito, Y
   Kawai, M
   Takebe, S
   Egawa, A
   Tanba, M
   Ishikawa, K
   Matsuoka, H
   Masaki, T
   Sunami, E
   Ohura, N
   Teruya, K
   Eto, K
   Nozawa, K
   Sakamoto, K
   Funahashi, K
AF Kojima, Koichiro
   Goto, Mayu
   Nagashima, Yasuo
   Saito, Yoko
   Kawai, Masaya
   Takebe, Shihori
   Egawa, Akiko
   Tanba, Mitsuko
   Ishikawa, Kazue
   Matsuoka, Hiroyoshi
   Masaki, Tadahiko
   Sunami, Eiji
   Ohura, Norihiko
   Teruya, Koji
   Eto, Ken
   Nozawa, Keijiro
   Sakamoto, Kazuhiro
   Funahashi, Kimihiko
TI Effectiveness of negative pressure wound therapy for the wound of
   ileostomy closure: a multicenter, phase II randomized controlled trial
SO BMC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Ileostomy closure; Wound healing;
   Surgical site infection; Purse-string suture; Randomized controlled
   trial; Phase II trial
ID SURGICAL SITE INFECTION; SKIN CLOSURE
AB Background The American Society of Surgery and American Society for Surgical Infections issued guidelines for surgical site infections (SSIs) in December 2016. These guidelines recommend a purse-string suture (PSS) for stoma closure as it facilitates granulation and enables open wound drainage. This study investigated the effect of using negative pressure wound therapy (NPWT) along with standard PSS and aimed to determine the optimal period of NPWT use. Methods The patients were divided into three groups as follows: Group A, postoperative wound management alone with gauze exchange as the representative of conventional PSS; Group B, the performed management was similar to that of Group A plus NPWT for 1 week; and Group C, the performed management was similar to that of Group A plus NPWT for 2 weeks. Regarding objective measures, the wound reduction rate was the primary outcome, and the incidence of SSIs, length of hospital stay, and wound healing duration were the secondary outcomes. Results In total, 30 patients (male: 18, female: 12) were enrolled. The average age was 63 (range: 43-84) years. The wound reduction rate was significantly higher in Group B than in Group A on postoperative days (PODs) 7 (66.1 vs. 48.4%, p = 0.049) and 10 (78.6 vs. 58.2%, p = 0.011), whereas no significant difference was observed on POD 14. Compared with Group A, Group C (POD 7: 65.9%, POD 10: 69.2%) showed an increase in the wound reduction rate on POD 7, although the difference was not significant (p = 0.075). SSIs were observed in Groups B (n = 2) and C (n = 2) (20%) but not in Group A (0%). Conclusions The most effective duration of NPWT use for ileostomy closure with PSS in terms of the maximum wound reduction rate was from PODs 3 to 10. However, NPWT did not shorten the wound healing duration. NPWT may reduce the wound size but should be used with precautions for SSIs. The small sample size (30 cases), the use of only one type of NPWT system, and the fact that wound assessment was subjective and not blinded were the limitations of this study. Further studies are needed to confirm our findings. Trial registration: UMIN Clinical Trials Registry; UMIN000032174 (10/04/2018).
C1 [Kojima, Koichiro; Masaki, Tadahiko; Sunami, Eiji] Kyorin Univ, Dept Surg, Sch Med, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611, Japan.
   [Goto, Mayu; Nagashima, Yasuo; Funahashi, Kimihiko] Toho Univ, Dept Gen & Gastroenterol Surg, Omori Med Ctr, Tokyo, Japan.
   [Saito, Yoko] Toho Univ, Dept Nursing, WOCN, Omori Med Ctr, Tokyo, Japan.
   [Kawai, Masaya; Sakamoto, Kazuhiro] Juntendo Univ, Dept Coloproctol Surg, Sch Med, Tokyo, Japan.
   [Takebe, Shihori] Juntendo Univ, Sch Med, Dept Nursing, WOCN, Tokyo, Japan.
   [Egawa, Akiko] Jikei Univ, Dept Nursing, WOCN, Sch Med, Tokyo, Japan.
   [Tanba, Mitsuko] Kyorin Univ, Dept Nursing, WOCN, Sch Med, Tokyo, Japan.
   [Ishikawa, Kazue] Teikyo Univ, Dept Nursing, WOCN, Sch Med, Tokyo, Japan.
   [Matsuoka, Hiroyoshi] Kyorin Univ, Dept Paramed, Fac Hlth Sci, Tokyo, Japan.
   [Ohura, Norihiko] Kyorin Univ, Sch Med, Dept Plast Reconstruct & Aesthet Surg, Tokyo, Japan.
   [Teruya, Koji] Kyorin Univ, Dept Hlth & Welf, Fac Hlth Sci, Tokyo, Japan.
   [Eto, Ken] Jikei Univ, Sch Med, Dept Surg, Tokyo, Japan.
   [Nozawa, Keijiro] Teikyo Univ, Dept Surg, Sch Med, Tokyo, Japan.
C3 Kyorin University; Toho University; Toho University; Juntendo
   University; Juntendo University; Jikei University; Kyorin University;
   Teikyo University; Kyorin University; Kyorin University; Kyorin
   University; Jikei University; Teikyo University
RP Kojima, K (通讯作者)，Kyorin Univ, Dept Surg, Sch Med, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611, Japan.
EM k-kojikoji@ks.kyorin-u.ac.jp
RI Tadahiko, Masaki/AAE-6843-2019
OI Eto, Ken/0000-0002-3628-4493
CR Amamo K, 2019, SURG TODAY, V49, P231, DOI 10.1007/s00595-018-1729-5
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NR 19
TC 12
Z9 16
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD DEC 28
PY 2021
VL 21
IS 1
AR 442
DI 10.1186/s12893-021-01446-2
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XW2AQ
UT WOS:000735429100002
PM 34963451
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Phang, ZH
   Khoo, SS
   Gunasagaran, J
   Ahmad, TST
AF Phang, Zi Hao
   Khoo, Saw Sian
   Gunasagaran, Jayaletchumi
   Ahmad, Tunku Sara Tunku
TI Clinical outcome of Maggot Debridement Therapy followed by Negative
   Pressure Wound Therapy for chronic hand wound with Multi-Drug Resistant
   Organism infection: Two cases and review of the literature
SO JOURNAL OF ORTHOPAEDIC SURGERY
LA English
DT Review
DE maggot; hand; infection; wound; dressing; antibiotic resistance
ID LUCILIA-CUPRINA
AB The advancement in science and research has led to development of medical maggots which feed exclusively on dead tissue. Medical maggots have three important functions namely debridement, disinfection, and stimulation of wound healing. The modern use of medical maggots now goes by the term "Maggot Debridement Therapy" (MDT) for use in wound management. MDT is still used infrequently due to the effectiveness of surgical debridement and antibiotics for treatment of wound infection. Lately, there was emergence of Multi-Drug Resistant Organism (MDRO) likely due to inappropriate antibiotics usage. Maggot secretions have been shown to be effective in inhibiting some MDRO, for example, Methicillin-resistant Staphylococcus aureus, thus making MDT an attractive option for wounds with MDRO. We report two patients with multiple medical comorbidities, diagnosed with serious MDRO Diabetic Hand Infections treated with three cycles of MDT followed by Negative Pressure Wound Therapy.
C1 [Phang, Zi Hao; Khoo, Saw Sian; Gunasagaran, Jayaletchumi; Ahmad, Tunku Sara Tunku] Univ Malaya, Fac Med, Natl Orthopaed Ctr Excellence Res & Learning NOCE, Dept Orthopaed Surg, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya
RP Phang, ZH (通讯作者)，Univ Malaya, Fac Med, Natl Orthopaed Ctr Excellence Res & Learning NOCE, Dept Orthopaed Surg, Kuala Lumpur 50603, Malaysia.
EM phangzh@ummc.edu.my
RI Gunasagaran, Jayaletchumi/J-4601-2019; Phang, Zi Hao/AAA-5535-2020;
   Khoo, Saw Sian/ABG-1514-2021; Ahmad, Tunku Sara/B-9979-2010
OI Gunasagaran, Jayaletchumi/0000-0001-5398-6545; Phang, Zi
   Hao/0000-0001-8703-1069; Khoo, Saw Sian/0000-0003-4584-2642; 
CR Armstrong DG, 2005, J AM PODIAT MED ASSN, V95, P254, DOI 10.7547/0950254
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NR 32
TC 4
Z9 6
U1 2
U2 17
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1022-5536
EI 2309-4990
J9 J ORTHOP SURG-HONG K
JI J. Orthop. Surg.
PD SEP
PY 2021
VL 29
IS 3
AR 23094990211067302
DI 10.1177/23094990211067302
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA XW6FW
UT WOS:000735713600001
PM 34920683
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhang, S
   Xie, YL
   Yan, FF
   Zhang, YF
   Yang, ZQ
   Chen, Z
   Zhao, Y
   Huang, Z
   Cai, L
   Deng, ZM
AF Zhang, Sheng
   Xie, Yuanlong
   Yan, Feifei
   Zhang, Yufeng
   Yang, Zhiqiang
   Chen, Zhe
   Zhao, Yong
   Huang, Zan
   Cai, Lin
   Deng, Zhouming
TI Negative pressure wound therapy improves bone regeneration by promoting
   osteogenic differentiation via the AMPK-ULK1-autophagy axis
SO AUTOPHAGY
LA English
DT Article
DE AMPK; bone nonunion; bone regeneration; macroautophagy; autophagy;
   mesenchymal stem cells; negative pressure wound therapy; osteoblast
   differentiation; ULK1
ID MESENCHYMAL STEM-CELLS; NON-UNIONS; R PACKAGE; AMPK; PHOSPHORYLATION;
   AUTOPHAGY; SIZE; PROLIFERATION; MECHANISMS; GUIDELINES
AB Deficient bone regeneration causes bone defects or nonunion in a substantial proportion of trauma patients that urges for novel therapies. To develop a reliable therapy, we investigated the effect of negative pressure wound therapy (NPWT) on bone regeneration in vivo in a rat calvarial defect model. Negative pressure (NP) treatment in vitro was mimicked to test its effect on osteoblast differentiation in rat mesenchymal stem cells (MSCs) and MC3T3-E1 cells. Transcriptomic analyses, pharmaceutical interventions, and shRNA knockdowns were conducted to explore the underlying mechanism and their clinical relevance was investigated in samples from patients with nonunion. The potential application of a combined therapy of MSCs in hydrogels with negative pressure was tested in the rat critical-size calvarial defect model. We found that NPWT promoted bone regeneration in vivo and NP treatment induced osteoblast differentiation in vitro. NP induced osteogenesis via activating macroautophagy/autophagy by AMPK-ULK1 signaling that was impaired in clinical samples from patients with nonunion. More importantly, the combined therapy involving MSCs in hydrogels with negative pressure significantly improved bone regeneration in rat critical-size calvarial defect model. Thus, our study identifies a novel AMPK-ULK1-autophagy axis by which negative pressure promotes osteoblast differentiation of MSCs and bone regeneration. NPWT treatment can potentially be adopted for therapy of bone defects.
C1 [Zhang, Sheng; Xie, Yuanlong; Yan, Feifei; Zhang, Yufeng; Yang, Zhiqiang; Chen, Zhe; Zhao, Yong; Cai, Lin; Deng, Zhouming] Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 163 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
   [Huang, Zan] Wuhan Univ, Dept Biochem, Key Lab Cell Hemostasis Hubei Prov, Coll Life Sci, Wuhan, Hubei, Peoples R China.
   [Huang, Zan] Shanghai Childrens Hosp, Nhc Key Lab Med Embryogenesis & Dev Mol Biol, Shanghai Key Lab Embryo & Reprod Engn, Shanghai, Peoples R China.
C3 Wuhan University; Wuhan University; Shanghai Jiao Tong University
RP Cai, L; Deng, ZM (通讯作者)，Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 163 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.; Huang, Z (通讯作者)，Wuhan Univ, Coll Life Sci, Key Lab Cell Hemostasis Hubei Prov, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China.
EM z-huang@whu.edu.cn; orthopedics@whu.edu.cn; dengzhouming@foxmail.com
RI Zhang, Yufeng/GZL-1973-2022; Xie, Yuanlong/V-7190-2019; Yan,
   Feifei/GRX-6364-2022
OI Zhang, Yufeng/0000-0003-3610-5229; Deng, Zhouming/0000-0003-3473-4101;
   Zhang, Sheng/0000-0002-1436-4265; Deng, Zhouming/0000-0003-3052-6241;
   Cai, Lin/0000-0003-3126-6429; 
FU National Natural Science Foundation of China [81870162, 81870427,
   81702150]
FX This work was supported by the National Natural Science Foundation of
   China [81870162]; National Natural Science Foundation of China
   [81870427]; National Natural Science Foundation of China [81702150].
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NR 51
TC 108
Z9 118
U1 1
U2 83
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1554-8627
EI 1554-8635
J9 AUTOPHAGY
JI Autophagy
PD SEP 2
PY 2022
VL 18
IS 9
BP 2229
EP 2245
DI 10.1080/15548627.2021.2016231
EA DEC 2021
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 3X3NQ
UT WOS:000735815300001
PM 34964701
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ring, A
   Beutel, H
   Bushart, SU
   Dellmann, NC
   Gousias, K
AF Ring, Andrej
   Beutel, Hendrik
   Bushart, Sebastian Ulrich
   Dellmann, Niklas-Chris
   Gousias, Konstantinos
TI Perforator-based keystone flap in the reconstruction of extensive tissue
   defects after lumbosacral spondylodesis
SO UNFALLCHIRURGIE
LA German
DT Article
DE Spinal surgery; Surgical site infection; NPWT; Reconstruction; Plastic
   surgery
ID SPINAL SURGERY; ISLAND FLAP; INFECTION; MANAGEMENT; OPTIONS
AB Background Prolonged surgical site infections after spinal fusion surgery may lead to exposure of the implant due to the formation of extensive tissue defects and endanger the clinical outcome. Objective This study aims to enlighten the role of the keystone perforator flap method in the reconstruction of lumbar soft tissue defects. Material and methods The retrospective study included 11 consecutive patients with a wound dehiscence of over 6 x 6 cm defect area persisting for 2 weeks after spinal fusion. The keystone perforator flap was applied for the reconstruction of tissue defects, whereas the arterial blood supply of the flaps was based on the intramuscular and intermuscular perforating branches of the dorsal branches of the lumbar arteries. Results The median age of our cohort was 58 years. The median body mass index (BMI) and Charlson comorbidity index (CCI) were 29.9 and 3.4, respectively. In eight cases a lumbosacral was carried out whereas in the remaining series a lumbar fusion was performed. In the course of the subsequent wound revision, on average 4 applications of negative pressure wound therapy (NPWT) were performed. The average defect size was 7.5 cm in width and 16.5 cm in length. The microbiological analysis of the tissue samples obtained intraoperatively after repeated NPWT revealed positive evidence of pathogenic bacteria in all cases. The average duration of inpatient treatment after flap surgery was 15 days, which was significantly shorter than the NPWT management of the open defect wounds (15.5 +/- 2.5 vs. 37 +/- 16.5, p < 0.05). Conclusion The keystone perforator flap offers a stable coverage for soft tissue defects and supports infection control after spinal fusion.
C1 [Ring, Andrej; Bushart, Sebastian Ulrich; Dellmann, Niklas-Chris] Katholische St Paulus Gesell, Klin Plast Chirurg, St Rochus Hosp, Gluckaufstr 10, D-44575 Castrop Rauxel, Germany.
   [Beutel, Hendrik] Ruhr Univ, Bochum, Germany.
   [Gousias, Konstantinos] Katholische St Paulus Gesell, Klin Neurochirurg, St Marien Hosp, Lunen, Germany.
C3 Ruhr University Bochum; St. Marien Hospital
RP Ring, A (通讯作者)，Katholische St Paulus Gesell, Klin Plast Chirurg, St Rochus Hosp, Gluckaufstr 10, D-44575 Castrop Rauxel, Germany.
EM andrej.ring@rub.de
RI Ring, Anej/AAK-1768-2021
OI Ring, Anej/0000-0002-2202-6370
CR Behan F, 2003, ANZ J SURG, V73, P112, DOI 10.1046/j.1445-2197.2003.02638.x
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   Chen SH, 2018, CLIN SPINE SURG, V31, P225, DOI 10.1097/BSD.0000000000000633
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   Kiil BJ, 2009, PLAST RECONSTR SURG, V123, P1229, DOI 10.1097/PRS.0b013e31819f299e
   Kolbenschlag J, 2015, ZBL CHIR, V140, P179, DOI 10.1055/s-0035-1545782
   Lall RR, 2015, J CLIN NEUROSCI, V22, P238, DOI 10.1016/j.jocn.2014.07.010
   Maruo K, 2014, J ORTHOP SCI, V19, P398, DOI 10.1007/s00776-014-0545-z
   Mujtaba B, 2019, CLIN RADIOL, V74, P756, DOI 10.1016/j.crad.2019.05.032
   Parpaley Y, 2011, NEUROSURGERY, V68, pE277, DOI 10.1227/NEU.0b013e3181fead14
   Prinz Vincent, 2020, J Spine Surg, V6, P777, DOI [10.21037/jss-20-514, 10.21037/jss-20-514]
   Smith JS, 2011, SPINE, V36, P556, DOI 10.1097/BRS.0b013e3181eadd41
NR 21
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2731-7021
EI 2731-703X
J9 UNFALLCHIRURGIE
JI Unfallchirurgie
PD DEC
PY 2022
VL 125
IS 12
SI SI
BP 975
EP 982
DI 10.1007/s00113-021-01128-x
EA JAN 2022
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 6O5XI
UT WOS:000737775000001
PM 34981136
DA 2026-07-24
ER
PT J
AU Bakula, B
   Sever, M
   Karacic, A
   Bakula, M
   Grbavac, M
   Romic, I
   Bogut, A
   Zadro, Z
AF Bakula, Branko
   Sever, Marko
   Karacic, Andrija
   Bakula, Mirko
   Grbavac, Martin
   Romic, Ivan
   Bogut, Ante
   Zadro, Zvonko
TI Extensive Abdominal Skin Necrosis Following Anterior Component
   Separation for a Large Ventral Hernia: A Case Report
SO FRONTIERS IN SURGERY
LA English
DT Article
DE hernia recurrence; wound dehiscence; anterior component separation
   (ACS); postoperative complication; skin ischemia
ID INCISIONAL HERNIA; REPAIR
AB Introduction: Hernia surgery is one of the most common operative procedures, performed in about 20 million cases per year all over the world, with ventral hernia accounting for about 30% of the cases. Although the introduction of the anterior component separation (ACS) method, popularized primarily by Oscar Ramirez, has greatly facilitated the closure of the largest abdominal wall defects, the 30-year experience in this technique has pointed to the risk of ischemic skin complications consequential to the major subcutaneous tissue dissection required. The aim of this case presentation of a patient who developed extensive necrosis of the abdominal wall skin following ACS procedure is to emphasize the importance of preserving rectus abdominis perforator blood vessels in order to preserve skin vitality.Case Presentation: We present a case of a 58-year-old female patient with a large recurrent ventral hernia. The hernial defect was closed by placing a large (30 x 25 cm) polypropylene mesh in the retro-rectus space using the Rives-Stoppa technique. To facilitate upper fascia closure ACS according to Ramirez was performed bilaterally. The rectus perforator vessels were not preserved. Recovery of the patient was complicated with the extensive abdominal skin necrosis which was successfully treated with negative pressure wound therapy.Discussion: Transection of the musculocutaneous perforators of the epigastric artery during ACS results with the compromised blood supply of the abdominal skin depending solely upon the intercostal arteries. Skin ischemia following ACS is a serious complication that can be presented with extensive necrosis associated with high morbidity and even mortality, while the treatment is long lasting, complex, and expensive. Considering the ever-increasing prevalence of large ventral hernias, ever greater popularity of the ACS technique, and the growing proportion of surgeons performing large ventral hernia operations independently, we think that the role of preserving perforated rectus vessels has not been emphasized enough. Therefore, the objective of this case study is to stimulate surgeons to preserve skin vascularity and promote it in their routine in order to avoid these severe postoperative complications.
C1 [Bakula, Branko; Sever, Marko; Karacic, Andrija; Grbavac, Martin; Zadro, Zvonko] Univ Hosp Sveti Duh, Dept Surg, Zagreb, Croatia.
   [Bakula, Mirko] Univ Hosp Ctr Zagreb, Dept Urol, Zagreb, Croatia.
   [Romic, Ivan] Univ Hosp Ctr Zagreb, Dept Surg, Zagreb, Croatia.
   [Bogut, Ante] Univ Hosp Mostar, Dept Gastroenterol, Mostar, Bosnia & Herceg.
C3 University of Zagreb; University of Zagreb Hospital; University of
   Zagreb; University of Zagreb Hospital; University of Mostar
RP Bakula, B (通讯作者)，Univ Hosp Sveti Duh, Dept Surg, Zagreb, Croatia.
EM bakulabranko@gmail.com
RI Romic, Ivan/ABF-2138-2021
CR Breuing K, 2010, SURGERY, V148, P544, DOI 10.1016/j.surg.2010.01.008
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NR 25
TC 1
Z9 3
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD DEC 17
PY 2021
VL 8
AR 779046
DI 10.3389/fsurg.2021.779046
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA YB2BK
UT WOS:000738824300001
PM 34977144
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fukuzaki, H
   Nakata, J
   Nojiri, S
   Shimizu, Y
   Kano, T
   Shirotani, Y
   Maeda, T
   Nohara, N
   Io, H
   Suzuki, Y
AF Fukuzaki, Haruna
   Nakata, Junichiro
   Nojiri, Shuko
   Shimizu, Yuki
   Kano, Toshiki
   Shirotani, Yuka
   Maeda, Takuya
   Nohara, Nao
   Io, Hiroaki
   Suzuki, Yusuke
TI Negative-pressure wound therapy is effective for peritoneal dialysis
   catheter exit-site management in the early postoperative period
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BED PREPARATION; SCORING SYSTEM; INFECTION
AB Peritoneal dialysis (PD) catheter exit-site care is critically important for the prevention of catheterrelated infections (CRIs) and subsequent peritonitis. The postoperative management of the site is particularly essential because it has an open wound that is always adjacent to a PD catheter tube. This study aimed to examine the effectiveness of negative-pressure wound therapy (NPWT) for postoperative PD catheter exit sites. Thirty patients with end-stage renal disease who underwent simultaneous PD catheter insertion and exit-site formation were randomly assigned to receive NPWT (NPWT group) or conventional dressing (non-NPWT group) for the first seven postoperative days. The exit-site scores on the seventh postoperative day was lower in the NPWT group than in the non-NPWT group (p = 0.0049). Analysis of variance F statistic for the effect of NPWT over 180 days was highly significant (11.482595, p = 0.007). There were no statistically significant differences between the time to first CRI and PD-related peritonitis between the two groups. There was one case of CRI with relapsing peritonitis and catheter loss in the non-NPWT group. These findings demonstrate the association between NPWT and low exit-site score. NPWT can be recommended for the management of PD catheter exit sites in the early postoperative period.
C1 [Fukuzaki, Haruna; Nakata, Junichiro; Shimizu, Yuki; Kano, Toshiki; Shirotani, Yuka; Maeda, Takuya; Nohara, Nao; Suzuki, Yusuke] Juntendo Univ, Dept Nephrol, Fac Med, Tokyo, Japan.
   [Nojiri, Shuko] Juntendo Univ, Med Technol Innovat Ctr, Tokyo, Japan.
   [Kano, Toshiki; Io, Hiroaki] Juntendo Univ, Dept Nephrol, Nerima Hosp, Tokyo, Japan.
C3 Juntendo University; Juntendo University; Juntendo University
RP Suzuki, Y (通讯作者)，Juntendo Univ, Dept Nephrol, Fac Med, Tokyo, Japan.
EM yusuke@juntendo.ac.jp
RI ; IO, Hiroaki/AGG-5274-2022
OI Shimizu, Yuki/0000-0002-6729-7414; 
FU Japan Society for the Promotion of Science [JP21K11199]
FX This study was partially supported by a Grant-in-Aid for Scientific
   Research (KAKENHI) from the Japan Society for the Promotion of Science
   grants JP21K11199 (to J. Nakata).
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NR 32
TC 2
Z9 3
U1 1
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 7
PY 2022
VL 12
IS 1
AR 70
DI 10.1038/s41598-021-03878-5
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA YD5VU
UT WOS:000740510500079
PM 34996968
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Seidel, D
   Lefering, R
AF Seidel, Dorthe
   Lefering, Rolf
TI NPWT Resource Use Compared With Conventional Wound Treatment in
   Subcutaneous Abdominal Wounds With Healing Impairment After Surgery
   SAWHI Randomized Clinical Trial Results
SO ANNALS OF SURGERY
LA English
DT Article
DE abdominal wound; conventional wound treatment; negative pressure wound
   therapy; resource use; surgical wound; wound healing; wound treatment
ID SURGICAL SITE INFECTIONS; VACUUM-ASSISTED CLOSURE; ECONOMIC BURDEN;
   THERAPY; QUALITY; IMPACT; CARE
AB Objective: To compare resource utilization of NPWT and CWT for SAWHI after surgery Summary of Background Data: NPWT is widely used in the management of complex wounds but high-level evidence of its resource use remains sparse. Methods: The multicenter, multinational, randomized clinical SAWHI study enrolled a total of 539 consecutive, compliant adult patients with SAWHI after surgery without fascial dehiscence between August 2, 2011, and January 31, 2018. Patients were randomly assigned to NPWT and CWT stratified by study site and wound size using a centralized web-based tool. Evaluation of direct resource use comprised inpatient and outpatient time, personnel and material for wound treatment, and associated wound-related procedures. The resource use analysis was primarily based on the per protocol population (NPWT 157; CWT 174). Results: Although treatment length within 42 days was significantly shorter in the NPWT arm {Mean [Standard deviation (SD)] NPWT 22.8 (13.4); CWT 30.6 (13.3); P < 0.001 U-test}, hospitalization time was shorter with CWT [Mean (SD) NPWT 13.9 (11.1); CWT 11.8 (10.8); P = 0.047 U-test]. Significantly more study participants were outpatient with CWT [N=167 (96.0%)] than with NPWT [N = 140 (89.2%) (P = 0.017)]. Time for dressing changes per study participant [Mean (SD) (min) NPWT N = 133, 196 (221.1); CWT N = 152, 278 (208.2); P < .001 U-test] and for wound-related procedures [Mean (SD) (min) NPWT 167 (195); CWT 266 (313); P < 0.001 U-test] was significantly lower with NPWT. Conclusions: NPWT reduces resource use and maybe an efficient treatment alternative to CWT for SAWHI after surgery.
C1 [Seidel, Dorthe; Lefering, Rolf] Witten Herdecke Univ, Inst Forsch Operativen Med IFOM, Cologne, Germany.
RP Seidel, D (通讯作者)，Witten Herdecke Univ, Inst Forsch Operativen Med IFOM, Cologne, Germany.
EM Doerthe.Seidel@uni-wh.de
OI Lefering, Rolf/0000-0002-0141-1747
FU manufacturer Kinetic Concepts Incorporated, an Acelity company part of
   3M Company, San Antonio, TX, USA
FX The SAWHI-study was funded by the manufacturer Kinetic Concepts
   Incorporated, an Acelity company, now part of 3M Company, San Antonio,
   TX, USA, which included the financing of personnel and material
   resources for planning, conduct, analysis, and report of the study. In
   addition, the manufacturer provided the vacuum assisted closure (VAC)
   therapy devices and associated consumable supplies.
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NR 25
TC 7
Z9 9
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD FEB
PY 2022
VL 275
IS 2
BP E290
EP E298
DI 10.1097/SLA.0000000000004960
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA YE0LP
UT WOS:000740824400021
PM 34117147
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Zargar, HR
   Mohsin, M
   Shah, RA
   Yasir, M
   Bhat, TA
   Wani, AH
AF Zargar, Haroon R.
   Mohsin, Mir
   Shah, Raheeb A.
   Yasir, Mir
   Bhat, Tanveer A.
   Wani, Adil H.
TI Successful management of complex scalp wounds with exposed calvarial
   bones by customized Negative pressure wound therapy (NPWT): Case series
   and review of the literature
SO TROPICAL DOCTOR
LA English
DT Review
DE Calvarium; negative pressure wound therapy; scalp; wounds; injuries;
   drill holes
AB Scalp wounds with exposed calvarial bones continue to be a challenge especially when no local flap options are available and no microvascular flaps can be performed. Our prospective study looked at 19 patients (14 males) where customized negative pressure wound treatment was used till the complex scalp wounds, mostly from animal bites, were covered with healthy granulation and grafted. Scalp wounds ranged from 6 x 4 cm to 17 x 11 cm in size whereas the area of exposed bone ranged from 1 x 2 cm to 10 x 10 cm. No major complication was seen, and wounds were rapidly healed.
C1 [Zargar, Haroon R.; Mohsin, Mir; Shah, Raheeb A.; Yasir, Mir; Bhat, Tanveer A.; Wani, Adil H.] Sheri Kashmir Inst Med Sci, Dept Plast & Reconstruct Surg, Srinagar 190011, J&K, India.
C3 Sher-i-Kashmir Institute of Medical Sciences
RP Mohsin, M (通讯作者)，Sheri Kashmir Inst Med Sci, Dept Plast & Reconstruct Surg, Srinagar 190011, J&K, India.
EM m_mohsin@rediffmail.com
RI Mohsin, Mir/AAA-1246-2022
OI Mohsin, Mir/0000-0001-8503-2543; , Raheeb Ahmad Shah/0009-0006-5845-8649
CR Dedmond BT, 2007, J ORTHOP TRAUMA, V21, P11, DOI 10.1097/BOT.0b013e31802cbc54
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   Liu X, 2018, INT J SURG, V53, P72, DOI 10.1016/j.ijsu.2018.02.064
   Mohsin M, 2017, INDIAN J PLAST SURG, V50, P43, DOI 10.4103/ijps.IJPS_196_16
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NR 9
TC 1
Z9 1
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0049-4755
EI 1758-1133
J9 TROP DOCT
JI Trop. Dr.
PD APR
PY 2022
VL 52
IS 2
BP 258
EP 261
AR 00494755211043377
DI 10.1177/00494755211043377
EA JAN 2022
PG 4
WC Public, Environmental & Occupational Health; Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 2H3QB
UT WOS:000740971200001
PM 34985345
DA 2026-07-24
ER
PT J
AU Guo, CC
   Cheng, T
   Li, JS
AF Guo, Chenchen
   Cheng, Tao
   Li, Junsheng
TI Prophylactic negative pressure wound therapy for closed laparotomy
   incisions after ventral hernia repair: A systematic review and
   meta-analysis
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Review
DE Prophylactic negative pressure wound therapy; pNPWT; Ventral hernia;
   Incisional hernia; Surgical site infection; SSI
ID SURGICAL SITE INFECTION; RISK; PREVENTION; MANAGEMENT
AB Purpose: To evaluate the efficacy of prophylactic negative pressure wound therapy (pNPWT) in preventing surgical site infection (SSI), hernia recurrence and other wound complications following closed laparotomy incisions following ventral hernia repair (VHR).
   Methods: A comprehensive literature search of PubMed, the Cochrane Central Register of Controlled Trials, Embase and ClinicalTrials.gov databases was performed from inception until June 30, 2021, to identify all online English publications comparing the use of pNPWT with standard dressing for closed laparotomy incision following VHR.
   Results: One RCT and eleven retrospective cohort studies involving 1355 patients satisfied the basic inclusion criteria. The use of pNPWT reduced SSI (OR = 0.39 [95% CI: 0.24-0.62] P < 0.0001) and surgical site occurrence (SSO) (OR = 0.51 [95% CI: 0.27-0.98] P = 0.04). No statistically significant difference was detected in the incidence of hernia recurrence (OR = 0.61 [95% CI: 0.30-1.26] P = 0.18), seroma (OR = 0.70 [95% CI: 0.48-1.03]P = 0.07), hematoma (OR = 0.77 [95% CI: 0.33-1.81]P = 0.55) and wound dehiscence (OR = 0.68 [95% CI: 0.43-1.08]P = 0.10).
   Conclusion: Use of pNPWT for closed laparotomy incisions following ventral hernia repair can significantly reduce the rate of postoperative surgical site infection (especially for superficial SIS) and surgical site occurrences. The number needed to treat (NNT) for preventing one occurrence of SSI is 9 patients. However, further research and more high quality studies are required to assess the effectiveness and assist in clarifying the role of pNPWT for closed laparotomy incisions following ventral hernia repair, preferentially in high-risk populations of developing SSI.
C1 [Guo, Chenchen] Southeast Univ, Sch Med, Nanjing 210009, Peoples R China.
   [Cheng, Tao; Li, Junsheng] Southeast Univ, Affiliated Zhongda Hosp, Dept Gen Surg, Nanjing 210009, Peoples R China.
C3 Southeast University - China; Southeast University - China
RP Li, JS (通讯作者)，Southeast Univ, Affiliated Zhongda Hosp, Dept Gen Surg, Nanjing 210009, Peoples R China.
EM Lijunshenghd@126.com
RI ; Li, Junsheng/E-4990-2013
OI Guo, Chenchen/0000-0003-3182-8671; 
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NR 35
TC 16
Z9 18
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD JAN
PY 2022
VL 97
AR 106216
DI 10.1016/j.ijsu.2021.106216
EA JAN 2022
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA YF5CU
UT WOS:000741825200008
PM 34990831
DA 2026-07-24
ER
PT J
AU Wu, LJ
   Wen, BY
   Xu, ZR
   Lin, KF
AF Wu, Lijiao
   Wen, Baoyu
   Xu, Zhaorong
   Lin, Kefeng
TI Research progress on negative pressure wound therapy with instillation
   in the treatment of orthopaedic wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE instillation; negative pressure wound therapy; orthopaedic wounds;
   treatment parameters
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURY; DWELL TIME; ANTISEPTIC
   SOLUTION; BACTERIAL LOAD; NORMAL SALINE; MANAGEMENT; FOAM; GROWTH
AB Negative pressure wound therapy with instillation (NPWTi) has the dual function of negative pressure sealing drainage and irrigation, which overcomes the disadvantages of NPWT, such as tube obstruction, inability to apply topical medicine, and poor anti-infection ability. NPWTi has been researched extensively and widely used in various types of wounds, and certain effects have been achieved. A series of parameters for NPWTi have not been unified at present, including the flushing fluid option, flushing mode, and treatment period. This paper reviews the research progress of these parameters for NPWTi and their application in the treatment of orthopaedic wounds.
C1 [Wu, Lijiao; Wen, Baoyu; Lin, Kefeng] Fujian Prov Hosp, Dept Orthoped Surg, Jinshan Branch, 516 South Jinrong Rd, Fuzhou, Fuzhou, Peoples R China.
   [Wu, Lijiao; Wen, Baoyu; Lin, Kefeng] Fujian Med Univ, Shengli Clin Med Coll, Fuzhou, Peoples R China.
   [Xu, Zhaorong] Fujian Med Univ, Bum & Wound Repair Dept, Union Hosp, Fuzhou, Peoples R China.
C3 Fujian Provincial Hospital; Fujian Medical University; Fujian Medical
   University
RP Lin, KF (通讯作者)，Fujian Prov Hosp, Dept Orthoped Surg, Jinshan Branch, 516 South Jinrong Rd, Fuzhou, Fuzhou, Peoples R China.
EM kefenglin@foxmail.com
FU National Natural Science Foundation of China [82002034]
FX The authors are grateful to HL Guan and J Yan of the Department of
   Orthopedic Surgery for their kind assistance and support. This work was
   supported by the National Natural Science Foundation of China (Grant No.
   82002034).
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NR 48
TC 13
Z9 17
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2022
VL 19
IS 6
BP 1449
EP 1455
DI 10.1111/iwj.13741
EA JAN 2022
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 4T2LH
UT WOS:000742223200001
PM 35029043
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Janssen, N
   Laven, IEWG
   Daemen, JHT
   Hulsewé, KWE
   Vissers, YLJ
   de Loos, ER
AF Janssen, Nicky
   Laven, Iris E. W. G.
   Daemen, Jean H. T.
   Hulsewe, Karel W. E.
   Vissers, Yvonne L. J.
   de Loos, Erik R.
TI Negative pressure wound therapy for massive subcutaneous emphysema: a
   systematic review and case series
SO JOURNAL OF THORACIC DISEASE
LA English
DT Review
DE Negative pressure wound therapy; subcutaneous emphysema; systematic
   review; case series
ID MANAGEMENT; SUCTION; DRAIN
AB Background: Massive subcutaneous emphysema can cause considerable morbidity with respiratory distress. To resolve this emphysema in short-term, negative pressure wound therapy could be applied as added treatment modality. However, its use is sparsely reported, and a variety of techniques are being described. This study provides a systematic review of the available literature on the effectiveness of negative pressure wound therapy as treatment for massive subcutaneous emphysema. In addition, our institutional experience is reported through a case-series.
   Methods: The PubMed, Embase and Cochrane Library were systematically searched for publications on the use of negative pressure wound therapy for subcutaneous emphysema following thoracic surgery, trauma or spontaneous pneumothorax. Moreover, patients treated at our institution between 2019 and 2021 were retrospectively identified and analyzed.
   Results: The systematic review provided 10 articles presenting 23 cases. Studies demonstrated considerable heterogeneity regarding the location of incision, creation of prepectoral pocket, and surgical safety margin. Also closed incision negative pressure wound therapy and PICO(C) device were discussed. Despite the apparent heterogeneity, all techniques provided favorable outcomes. No complications, reinterventions or recurrences were documented. Furthermore, retrospective data of 11 patients treated at our clinic demonstrated an immediate response to negative pressure wound therapy and a full remission of the subcutaneous emphysema at the end of negative pressure wound therapy. No recurrence requiring intervention or complications were observed.
   Conclusions: The findings of this study suggest that negative pressure wound therapy, despite the varying techniques employed, is associated with an immediate regression of subcutaneous emphysema and full remission at the end of therapy. Given the relatively low sample size, no technique of choice could be identified. However, in general, negative pressure wound therapy appears to provide fast regression of subcutaneous emphysema and release of symptoms in all cases.
C1 [Janssen, Nicky; Laven, Iris E. W. G.; Daemen, Jean H. T.; Hulsewe, Karel W. E.; Vissers, Yvonne L. J.; de Loos, Erik R.] Zuyderland Med Ctr, Dept Surg, Div Gen Thorac Surg, Henri Dunantstr 5, NL-6419 PC Heerlen, Netherlands.
C3 Zuyderland Medical Center
RP de Loos, ER (通讯作者)，Zuyderland Med Ctr, Dept Surg, Div Gen Thorac Surg, Henri Dunantstr 5, NL-6419 PC Heerlen, Netherlands.
EM e.deloos@zuyderland.nl
OI Laven, Iris/0000-0001-8976-5293
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NR 18
TC 7
Z9 9
U1 0
U2 1
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2072-1439
EI 2077-6624
J9 J THORAC DIS
JI J. Thorac. Dis.
PD JAN
PY 2022
VL 14
IS 1
BP 43
EP +
DI 10.21037/jtd-21-1483
EA DEC 2021
PG 14
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA YX7SS
UT WOS:000742877100001
PM 35242367
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gibson, DJ
AF Gibson, Daniel J.
TI A Comparison of the Biomechanical Performance of 3 Negative Pressure
   Wound Therapy Foams
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE NPWT; NPWT design; NPWT dressings; NPWT testing
ID TISSUE
AB PURPOSE: The purpose of this study was to compare 3 foam dressings to (1) determine the biomechanical performance of existing negative pressure wound therapy (NPWT) foams and (2) to determine if a test foam is possibly suitable as an antimicrobial "white" foam alternative for use in NPWT. DESIGN: A comparison of mechanical performance of 3 foams used for vacuum-assisted NPWT. SUBJECTS AND SETTING: Preclinical laboratory study using an in vitro model. METHODS: The performance of a "white" foam (polyvinyl alcohol [PVA]), an antimicrobial "black" foam (polyurethane [PU]), and an antimicrobial white foam alternative (test PVA) were tested and compared using 3 mechanically relevant criteria. First, the fluid removal rate was measured for 72 hours. Next, the pressure input was compared to the pressure directly beneath the center of the foam. Finally, the spread of negative pressure beneath the foam was measured and compared. RESULTS: Significant differences were found in fluid removal rates; specifically, the PU foam removed fluids faster than the PVA and test PVA foams, and the currently available PVA foams performed similarly. Both the PU and test PVA foams were able to transmit the negative pressure through the center of the dressing, while the typical PVA foam began failing at 140 mm Hg, with 50% of the samples failing at 200 mm Hg. All PU replicate foams evenly distributed the pressure, while 47% to 60% of the test PVA foams and 7% of the typical PVA foams distributed pressures evenly. CONCLUSIONS: Study findings suggest that the test PVA foam does not mechanically interfere with NPWT and performs equivalently to currently used foams. These results suggest that the test PVA may be modified and incorporated into a vacuum-assisted NPWT device. In addition, the methods employed in these experiments provide a reproducible means to compare biomechanical compatibility of various NPWT foams, dressings, and subdrape devices.
C1 [Gibson, Daniel J.] Univ Alabama, Capstone Coll Nursing, 650 Univ Blvd E, Tuscaloosa, AL 35401 USA.
C3 University of Alabama System; University of Alabama Tuscaloosa
RP Gibson, DJ (通讯作者)，Univ Alabama, Capstone Coll Nursing, 650 Univ Blvd E, Tuscaloosa, AL 35401 USA.
EM dgibson1@ua.edu
RI Gibson, Daniel/LRC-9423-2024
FU Hollister Inc
FX The author conducted this research via a contract with Hollister Inc,
   which distributed one of the products subject herein. The product's
   manufacturer, Hydrofera, LLC, sponsored Dr Gibson's effort for
   composition and costs of publication. The sponsors chose the pressure
   distribution pattern beneath the dressing that they would like to be
   measured and manufactured the pressure table and supports. They did not
   have a role in the design of the measurement routine, conduct of the
   research, or data analysis. The sponsors did not write the manuscript
   but were allowed to review it for accuracy pertaining to comments made
   about the sponsors or their intents.
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NR 18
TC 5
Z9 5
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JAN-FEB
PY 2022
VL 49
IS 1
BP 51
EP 58
DI 10.1097/WON.0000000000000833
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA YI1HQ
UT WOS:000743607500009
PM 34855716
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Zhou, R
   Qiu, L
   Xiao, J
   Mao, XB
   Yuan, XG
AF Zhou, Rong
   Qiu, Lin
   Xiao, Jun
   Mao, Xiaobo
   Yuan, Xingang
TI Early Wound Repair Versus Later Scar Repair in Children with Treadmill
   Hand Friction Burns
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID SUBATMOSPHERIC PRESSURE; SKIN-GRAFTS; MANAGEMENT; INJURIES; CLOSURE;
   THERAPY
AB The incidence of pediatric treadmill hand friction burns has been increasing every year. The injuries are deeper than thermal hand burns, the optimal treatment remains unclear. This was a retrospective study of children who received surgery for treadmill hand friction burns from January 1, 2015, to December 31, 2019, in a single burn center. A total of 22 children were surveyed. The patients were naturally divided into two groups: the wound repair group (13 patients), which was admitted early to the hospital after injury and received debridement and vacuum sealing drainage initially, and a full-thickness skin graft later; and the scar repair group (nine patients), in which a scar contracture developed as a result of wound healing and received scar release and skin grafting later. The Modified Michigan Hand Questionnaire score in the wound repair group was 116.31 +/- 10.55, and the corresponding score in the scar repair group was 117.56 +/- 8.85 (p >.05), no statistically significant difference. The Vancouver Scar Scale score in the wound repair group was 4.15 +/- 1.21, and the corresponding score in the scar repair group was 7.22 +/- 1.09 (p <.05). Parents were satisfied with the postoperative appearance and function of the hand. None in the two groups required secondary surgery. If the burns are deep second degree, third degree, or infected, early debridement, vacuum sealing drainage initially, and a full-thickness skin graft can obviously relieve pediatric pain, shorten the course of the disease, and restore the function of the hand as soon as possible.
C1 [Zhou, Rong; Qiu, Lin; Xiao, Jun; Mao, Xiaobo; Yuan, Xingang] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Burns & Plast Surg,Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,Childre, Chongqing, Peoples R China.
C3 Chongqing Medical University
RP Yuan, XG (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Burns & Plast Surg, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China.
EM 535538769@qq.com
OI , Rong/0000-0001-7464-3525
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NR 27
TC 6
Z9 8
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2022
VL 43
IS 1
BP 269
EP 276
DI 10.1093/jbcr/irab083
EA MAY 2021
PG 8
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA YI7EI
UT WOS:000744007600037
PM 34015124
DA 2026-07-24
ER
PT J
AU Yane, Y
   Hida, J
   Chiba, Y
   Makutani, Y
   Ushijima, H
   Yoshioka, Y
   Iwamoto, M
   Wada, T
   Daito, K
   Tokoro, T
   Ueda, K
   Kawamura, J
AF Yane, Yoshinori
   Hida, Jin-ichi
   Chiba, Yasutaka
   Makutani, Yusuke
   Ushijima, Hokuto
   Yoshioka, Yasumasa
   Iwamoto, Masayoshi
   Wada, Toshiaki
   Daito, Koji
   Tokoro, Tadao
   Ueda, Kazuki
   Kawamura, Junichiro
TI Effectiveness of negative pressure wound therapy with instillation and
   dwelling after stoma closure: a retrospective and propensity score
   matching analysis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; LOOP ILEOSTOMY; SKIN
   CLOSURE; RISK-FACTORS; REVERSAL
AB The use of temporary diverting stoma has become more common in low colorectal anastomosis to reduce anastomotic complications. Surgical site infection (SSI) at the stoma closure site has been one of the most frequent postoperative complications. The aim of this study was to compare the short-term outcomes between conventional primary suture closure and negative pressure wound therapy with instillation and dwelling (NPWTi-d) therapy following purse-string suturing, using propensity score matching analysis. We retrospectively evaluated the medical records of 107 patients who underwent stoma closure between January 2016 and October 2020. The primary outcome was the proportion of SSI. The secondary outcome was the day of postoperative length of stay. Propensity score matching with one-to-one match was performed for reducing treatment selection bias. Of a total of 107 patients, 67 patients had been treated with conventional primary closure and 40 with NPWTi-d therapy. The propensity score matching derived 37 pairs. The respective SSI proportions were 0% and 16.2% in the groups with NPWTi-d and primary closure (P = 0.025). The respective median days of postoperative hospital stay were 9.0 and 10.0 in the groups with NPWTi-d and primary closure (P = 0.453). NPWTi-d therapy with purse-string suturing was effective in reducing SSI after stoma closure.
C1 [Yane, Yoshinori; Makutani, Yusuke; Ushijima, Hokuto; Yoshioka, Yasumasa; Iwamoto, Masayoshi; Wada, Toshiaki; Daito, Koji; Tokoro, Tadao; Ueda, Kazuki; Kawamura, Junichiro] Kindai Univ, Dept Surg, Fac Med, 377-2 Ohno Higashi, Osaka 5898511, Japan.
   [Hida, Jin-ichi] Kindai Univ, Dept Surg Gastroenterol, Nara Hosp, Nara, Japan.
   [Chiba, Yasutaka] Kindai Univ, Fac Med, Div Biostat, Clin Res Ctr, Osaka, Japan.
C3 Kindai University (Kinki University); Kindai University (Kinki
   University); Kindai University (Kinki University)
RP Kawamura, J (通讯作者)，Kindai Univ, Dept Surg, Fac Med, 377-2 Ohno Higashi, Osaka 5898511, Japan.
EM kawamuraj@med.kindai.ac.jp
RI Kawamura, Junichiro/H-9205-2019; Ueda, Kazuki/AAB-6618-2022; 幕谷,
   悠介/IAP-9683-2023
OI Kawamura, Junichiro/0000-0001-5404-5317; 
CR Amamo K, 2019, SURG TODAY, V49, P231, DOI 10.1007/s00595-018-1729-5
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NR 34
TC 4
Z9 4
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 18
PY 2022
VL 12
IS 1
AR 916
DI 10.1038/s41598-022-05016-1
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA YI8VH
UT WOS:000744120000079
PM 35042963
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ollat, D
   Vuilletet, E
   Zadegan, F
   Rougereau, G
AF Ollat, Didier
   Vuilletet, Emma
   Zadegan, Frederic
   Rougereau, Gregoire
TI Management of Posterior Digital Skin Defect by Pico Negative Pressure
   Wound Therapy A Case Report and Literature Review
SO ORTHOPAEDIC NURSING
LA English
DT Review
ID HAND; IRRIGATION
AB The use of negative pressure therapy for digital skin loss is uncommon. A reason for this is the difficulty of applying dressings to the hand, which are often difficult to seal. However, negative pressure therapy offers some benefits, especially when associated with local infection. We present a nonspecific, simple and original technique using a Pico negative pressure dressing that may be easily applied in daily practice.
C1 [Ollat, Didier; Vuilletet, Emma; Zadegan, Frederic; Rougereau, Gregoire] Inst Mutualiste Montsouris, Dept Orthoped Surg, 42 Blvd Jourdan, F-75014 Paris, France.
   [Rougereau, Gregoire] Sorbonne Univ, Dept Orthoped & Traumatol, Pitie Salpetriere Hosp, Paris, France.
C3 Universite Paris Cite; Institute Mutualiste Montsouris; Sorbonne
   Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP
RP Rougereau, G (通讯作者)，Inst Mutualiste Montsouris, Dept Orthoped Surg, 42 Blvd Jourdan, F-75014 Paris, France.
EM Didier.Ollat@imm.fr; emma.vuilletet@gmail.com; frederic.zadegan@imm.fr;
   greg.rougereau@gmail.com
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NR 15
TC 0
Z9 0
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0744-6020
EI 1542-538X
J9 ORTHOP NURS
JI Orthop. Nurs.
PD JAN-FEB
PY 2022
VL 41
IS 1
BP 21
EP 24
DI 10.1097/NOR.0000000000000816
PG 4
WC Nursing; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Orthopedics
GA YJ0BD
UT WOS:000744203500006
PM 35045538
DA 2026-07-24
ER
PT J
AU Zeybek, B
   Li, SM
   Silberschmidt, VV
   Liu, Y
AF Zeybek, Begum
   Li, Simin
   Silberschmidt, Vadim V.
   Liu, Yang
TI Wound contraction under negative pressure therapy measured with digital
   image correlation and finite-element analysis in tissue phantoms and
   wound models
SO MEDICAL ENGINEERING & PHYSICS
LA English
DT Article
DE Computational biomechanics; Negative pressure wound therapy; Wound
   phantoms; Soft tissue biomechanics; Deep tissue injuries
ID VACUUM-ASSISTED CLOSURE; MECHANICAL-BEHAVIOR; LOWER-LIMB; VALIDATION;
   MANAGEMENT; ADULTS; TOOL
AB The purpose of this study is to demonstrate the capabilities of finite-element (FE) models to predict contraction of wounds managed with negative pressure wound therapy (NPWT). The features of wounds and surrounding tissues were analysed to gain insights into the mechanical effects of NPWT on them. 3D digital image correlation (DIC) measurement of soft tissue phantoms was used to investigate the effect of wound thickness, size, and shape, which were further compared with results of FE simulations. It was noticed that with an increased NP level the difference between DIC and FE in wound contraction became more pronounced, particularly for the thick wounds. In addition, the locations of the wounds were evaluated to predict their contraction characteristics, based on surrounding tissue structures, in 3D using the developed FE models. It was demonstrated that features and location of wounds influenced their deformations differently for the same pressure levels. Overall, this study, involving a combined experimental and computational approach, allowed the important insights into mechanical effects of NPWT.
C1 [Zeybek, Begum; Li, Simin; Silberschmidt, Vadim V.; Liu, Yang] Loughborough Univ, Wolfson Sch Mech Elect & Mfg Engn, Loughborough, Leics, England.
   [Liu, Yang] Loughborough Univ, Ctr Biol Engn, Loughborough, Leics, England.
   [Zeybek, Begum] Teesside Univ, Sch Hlth & Life Sci, Middlesbrough, Cleveland, England.
C3 Loughborough University; Loughborough University; University of Teesside
RP Liu, Y (通讯作者)，Loughborough Univ, Wolfson Sch Mech Elect & Mfg Engn, Loughborough, Leics, England.; Liu, Y (通讯作者)，Loughborough Univ, Ctr Biol Engn, Loughborough, Leics, England.
EM Y.Liu@lboro.ac.uk
RI Liu, Yang/A-4046-2011; Li, Simin/A-8040-2015; Silberschmidt, Vadim
   V/G-7113-2011
OI Silberschmidt, Vadim V/0000-0003-3338-3311; Zeybek Saglam,
   Begum/0000-0001-6789-043X
FU Loughborough University, Wolfson School of Mechanical, Electrical and
   Manufacturing Engineering
FX This research was partially supported by Loughborough University,
   Wolfson School of Mechanical, Electrical and Manufacturing Engineering.
   We thank Thomas White, Assistant Professor, University of Nevada, Reno,
   USA for assistance with the DIC technique and providing his MATLAB
   source code, and Nelson Charles-Nwufoh (Loughborough University) for his
   assistance with the assessment of DIC measurement errors and improvement
   of the imaging system for the experiments.
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   Wong VW, 2011, J INVEST DERMATOL, V131, P2186, DOI 10.1038/jid.2011.212
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NR 57
TC 2
Z9 4
U1 0
U2 21
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1350-4533
EI 1873-4030
J9 MED ENG PHYS
JI Med. Eng. Phys.
PD DEC
PY 2021
VL 98
BP 104
EP 114
DI 10.1016/j.medengphy.2021.11.003
EA NOV 2021
PG 11
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA YJ0VY
UT WOS:000744258300002
PM 34848029
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Bota, O
   Martin, J
   Hammer, A
   Scherpf, M
   Matschke, K
   Dragu, A
   Malberg, H
AF Bota, Olimpiu
   Martin, Judy
   Hammer, Alexander
   Scherpf, Matthieu
   Matschke, Klaus
   Dragu, Adrian
   Malberg, Hagen
TI Topical negative pressure wound therapy enhances the local tissue
   perfusion - A pilot study
SO MICROVASCULAR RESEARCH
LA English
DT Article
DE Spectrophotometry; White light spectrometry; Laser Doppler spectroscopy;
   Topical negative pressure wound therapy; Cutaneous microcirculation;
   Tissue perfusion
ID LASER-DOPPLER; BLOOD-FLOW; ANOVA
AB Background: Topical negative pressure wound therapy (TNPWT) is a regularly used method in modern wound treatment with a growing and diverse potential for clinical use. So far positive effects on microcirculation have been observed and examined, although precise statements on the underlying mechanism appear unsatisfying.
   Objective: The aim of our study was to extend the understanding of the effect of TNPWT on tissue perfusion and determine the time frame and the extent to which the tissue perfusion changes due to TNPWT.
   Material and methods: TNPWT was applied to the anterior thighs of 40 healthy individuals for 30 min, respectively. Before and up to 90 min after the application, measurements of the amount of regional haemoglobin (rHb), capillary venous oxygen saturation (sO2), blood flow (flow) and velocity were conducted with spectrophotometry (combining white light spectrometry and laser Doppler spectroscopy) within two different depths/skin layers. A superficial measuring probe for depths up to 3 mm and a deep measuring probe for up to 7 mm were used.
   Results: All parameters show significant changes after the intervention compared to baseline measurements. The greater effect was seen superficially. The superficially measured rHb, sO2 and flow showed a significant increase and stayed above the baseline at the end of the protocol. Whereas deeply measured, the rHb initially showed a decrease. The flow and sO2 showed a significant increase up to 60 min after the intervention.
   Conclusion: The application of TNPWT on healthy tissue shows an increase in capillary-venous oxygen saturation and haemoglobin concentration of at least 90 min after intervention. A possible use in clinical practice for preconditioning to enhance wound healing for high-risk patients to develop wound healing disorder, requires further studies to investigate the actual duration of the effect.
C1 [Bota, Olimpiu; Martin, Judy; Dragu, Adrian] Tech Univ Dresden, Fac Med Carl Gustav Carus, Univ Ctr Orthoped, Fetscherstr 74, D-01307 Dresden, Germany.
   [Hammer, Alexander; Scherpf, Matthieu; Malberg, Hagen] Tech Univ Dresden, Inst Biomed Engn, Fetscherstr 29, D-01307 Dresden, Germany.
   [Matschke, Klaus] Tech Univ Dresden, Dept Cardiac Surg, Univ Heart Ctr Dresden, Fetscherstr 76, D-01307 Dresden, Germany.
C3 Technische Universitat Dresden; Technische Universitat Dresden;
   Technische Universitat Dresden
RP Bota, O (通讯作者)，Tech Univ Dresden, Fac Med Carl Gustav Carus, Univ Ctr Orthoped, Fetscherstr 74, D-01307 Dresden, Germany.
EM olimpiu.bota@uniklinikum-dresden.de
RI Bota, Olimpiu/AAN-4292-2021; Scherpf, Matthieu/AFI-8411-2022; Hammer,
   Alexander/LUY-9375-2024; Dragu, Adrian/AAH-3506-2019
OI Bota, Olimpiu/0000-0002-5836-1269; Scherpf,
   Matthieu/0000-0001-6754-5257; Hammer, Alexander/0000-0002-1984-580X;
   Dragu, Adrian/0000-0003-4633-2695
FU European Regional Development Fund [F-003661-553u4G-1250000, ERDF
   100278533]; The synergetic university of TU Dresden [ZUK 64]
FX This project was financed from a fund belonging to the subproject 4G
   which is part of the state excellence initiative for realization of the
   future project ZUK 64 "The synergetic university of TU Dresden" and the
   European Regional Development Fund (F-003661-553u4G-1250000; ERDF
   100278533) .
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 25
TC 5
Z9 6
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0026-2862
EI 1095-9319
J9 MICROVASC RES
JI Microvasc. Res.
PD MAR
PY 2022
VL 140
AR 104301
DI 10.1016/j.mvr.2021.104301
EA JAN 2022
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA YJ6NX
UT WOS:000744649500003
PM 34971695
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Robertson, MJ
   Lee, RC
   Bergin, PF
   Graves, ML
   Russell, G
AF Robertson, Michael J.
   Lee, Rowdy C.
   Bergin, Patrick F.
   Graves, Matthew L.
   Russell, George, V
TI Complications of Morbid Obesity in the Treatment of Acetabular
   Fractures: Re-evaluating Outcomes a Decade Later
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE acetabulum; acetabular fracture; orthopaedic trauma; obesity; morbid
   obesity; severe obesity; wound vac; negative pressure wound therapy;
   wound complication; polytrauma; complications
ID HETEROTOPIC OSSIFICATION PROPHYLAXIS; OPERATIVE TREATMENT; RISK;
   INDOMETHACIN; INCREASES; HIP
AB Objectives: To determine the rate of perioperative complications between morbidly obese (body mass index greater than 40 kg/m(2)) and nonmorbidly obese patients undergoing operative treatment of acetabular fractures across 2 periods (2000-2005 and 2012-2019). Design: Retrospective, case-control study. Setting: Level I academic trauma center. Patients: Four hundred thirty-five consecutive patients from 2000 to 2005 and 216 consecutive patients from 2012 to 2019 with acetabular fractures treated by a single surgeon. Intervention: Operative fixation of acetabular fracture. Main Outcome Measurements: Outcome variables include positioning time, operative time, estimated blood loss, hospital stay, wound complications, and perioperative complications. Results: Twenty-eight morbidly obese and 188 nonmorbidly obese patients from 2012 to 2019, as well as 41 morbidly obese patients and 394 nonmorbidly obese patients from 2000 to 2005 were included in the study. The relative risk (RR) of wound complications between 2012 and 2019 groups was significantly higher for morbidly obese patients (RR = 5.31, P = 0.009) but has decreased significantly for morbidly obese patients between 2000-2005 and 2012-2019 (RR = 0.31, P = 0.017). The rate of total perioperative complications was similar between morbidly obese and nonmorbidly obese groups from 2012 to 2019 (21% vs. 8%, P = 0.230). For morbidly obese patients, the rate of total perioperative complications decreased significantly between 2000-2005 and 2012-2019 (63% vs. 21% P = 0.010). Conclusion: Acetabular fracture surgery can be safely performed in morbidly obese patients. Although obesity remains a significant risk factor for wound complications, the risk for morbidly obese patients has decreased significantly since our initial investigation because of adaptations to surgical techniques and surgeon's experience.
C1 [Robertson, Michael J.; Lee, Rowdy C.; Bergin, Patrick F.; Graves, Matthew L.; Russell, George, V] Univ Mississippi, Dept Orthoped, Med Ctr, 2500 North State St, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center
RP Robertson, MJ (通讯作者)，Univ Mississippi, Dept Orthoped, Med Ctr, 2500 North State St, Jackson, MS 39216 USA.
EM mjrobertson@umc.edu
RI Russell, George/LQL-0206-2024
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NR 25
TC 3
Z9 3
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD FEB
PY 2022
VL 36
IS 2
BP 87
EP 92
DI 10.1097/BOT.0000000000002199
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA YK3LB
UT WOS:000745117700014
PM 34620777
DA 2026-07-24
ER
PT J
AU Huang, Y
   Mao, BQ
   Hu, JL
   Xu, B
   Ni, PW
   Hou, LL
   Xie, T
AF Huang, Yao
   Mao, Beiqian
   Hu, Jiale
   Xu, Bing
   Ni, Pengwen
   Hou, Lili
   Xie, Ting
TI Consensus on the health education of home-based negative pressure wound
   therapy for patients with chronic wounds: a modified Delphi study
SO BURNS & TRAUMA
LA English
DT Article
DE Wound healing; Negative pressure wound therapy; Home care services;
   Delphi study; Chronic wound; Self-care
ID CARE; DISCHARGE
AB Background: The study aimed to develop consensus on the components of health education of home-based negative pressure wound therapy (NPWT) for patients with chronic wounds.
   Methods: A Delphi method was used to achieve consensus on the components of health education and 75% agreement and coefficient of variation (CV) <0.25 were used as cutoff. Sixteen experts were recruited purposefully to finish this study.
   Results: Two rounds of consultation were implemented. Consensus was achieved on 36 of the 42 statements. The final agreed list of statements represented three domains: health education before carrying out home-based NPWT, health education for the treatment day of NPWT at hospital and health education for NPWT at home.
   Conclusions: This study was the first attempt to develop consensus on the comprehensive components of health education of home-based NPWT for patients with chronic wounds. According to the established framework and components of health education, wound professionals can safely and effectively implement health education of home-based NPWT for patients with chronic wounds and improve their self-care ability and treatment experience at home.
C1 [Huang, Yao; Mao, Beiqian; Xu, Bing; Ni, Pengwen; Xie, Ting] Shanghai Jiao Tong Univ, Wound Healing Ctr Emergency Dept, Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China.
   [Huang, Yao] Shanghai Jiao Tong Univ, Sch Nursing, Shanghai 200025, Peoples R China.
   [Hu, Jiale] Virginia Commonwealth Univ, Dept Nurse Anesthesia, Richmond, VA 23298 USA.
   [Hou, Lili] Shanghai Jiao Tong Univ, Nursing Dept, Sch Med, Peoples Hosp 9, Shanghai 200011, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Virginia
   Commonwealth University; Shanghai Jiao Tong University
RP Xie, T (通讯作者)，Shanghai Jiao Tong Univ, Wound Healing Ctr Emergency Dept, Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China.; Hou, LL (通讯作者)，Shanghai Jiao Tong Univ, Nursing Dept, Sch Med, Peoples Hosp 9, Shanghai 200011, Peoples R China.
EM houlili1977@hotmail.com; doctortingxie@139.com
RI Hu, Jiale/I-3949-2019
FU Shanghai Jiao Tong University School of Medicine-Nursing research
   project [Jyh1905]; Gaoyuan Nursing Grant Support of Shanghai Municipal
   Education Commission [hlgy1904dxk]; Nursing research project of Ninth
   People's Hospital Affiliated to Shanghai Jiao Tong University School of
   Medicine [JYHL20193D06]; Shanghai 'Rising Stars of Medical Talent' Youth
   Development Nursing Program; Shanghai Nursing Association Young Talent
   Seedling Program
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship and/or publication of this article: this
   program was supported by grants from Shanghai Jiao Tong University
   School of Medicine-Nursing research project (Jyh1905); Gaoyuan Nursing
   Grant Support of Shanghai Municipal Education Commission (hlgy1904dxk);
   Nursing research project of Ninth People's Hospital Affiliated to
   Shanghai Jiao Tong University School of Medicine (JYHL20193D06);
   Shanghai `Rising Stars of Medical Talent' Youth Development Nursing
   Program; Shanghai Nursing Association Young Talent Seedling Program.
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NR 36
TC 11
Z9 14
U1 2
U2 21
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2321-3868
EI 2321-3876
J9 BURNS TRAUMA
JI Burns Trauma
PY 2021
VL 9
AR tkab046
DI 10.1093/burnst/tkab046
EA DEC 2021
PG 10
WC Emergency Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Emergency Medicine; Dermatology; Surgery
GA YL1VH
UT WOS:000745686300011
PM 34993255
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Orlov, A
   Gefen, A
AF Orlov, Aleksei
   Gefen, Amit
TI The potential of a canister-based single-use negative-pressure wound
   therapy system delivering a greater and continuous absolute pressure
   level to facilitate better surgical wound care
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE animal study; bioengineering laboratory research; closed incision;
   finite element modelling; lateral tension sutures
ID VACUUM-ASSISTED CLOSURE; EVIDENCE-BASED RECOMMENDATIONS; TISSUE LOADS;
   INCISION; MANAGEMENT; INFECTION; DEVICE; SURGERY; STEPS
AB Two types of single-use negative-pressure wound therapy systems are currently available to treat surgical wounds: Canister-based and canisterless. This work was aimed to evaluate the performance of a canister-based vs a canisterless system, each with a different negative-pressure setting and technology for fluid management. Continuous delivery of a specified level of negative pressure to the wound bed is hypothesised to be important for promoting surgical wound healing, by achieving continuous reduction of lateral tension in the wound, particularly through decrease of skin stress concentrations around suture insertion sites. To test the above hypothesis, we developed a computational modelling framework, a laboratory bench-test for simulated clinical use and had further conducted a pre-clinical study in a porcine model for closed incision. We specifically focussed on the impact of effective fluid management for continuous delivery of a stable, consistent negative pressure and the consequences of potential losses of the pressure level over the therapy period. We found that a greater (absolute) negative-pressure level and its continuous, consistent delivery through controlled fluid management technology, by removing excess fluid from the dressing, provides far superior biomechanical performances. These conditions are more likely to result in better quality of the repaired tissues.
C1 [Orlov, Aleksei; Gefen, Amit] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-6997801 Tel Aviv, Israel.
C3 Tel Aviv University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-6997801 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
OI Gefen, Amit/0000-0002-0223-7218
FU H2020 Marie Sklodowska-Curie Actions [811965]; project STINTS (Skin
   Tissue Integrity under Shear); Ministry of Science, Technology and Space
   [3-17421]; Molnlycke Health Care (Gothenburg, Sweden)
FX H2020 Marie Sklodowska-Curie Actions, Grant/Award Number: 811965;
   project STINTS (Skin Tissue Integrity under Shear); Ministry of Science,
   Technology and Space, Grant/Award Number: Medical Devices Program Grant
   no. 3-17421; Molnlycke Health Care (Gothenburg, Sweden)
CR [Anonymous], 3D IMAGE SEGMENTATIO
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NR 63
TC 10
Z9 11
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2022
VL 19
IS 6
BP 1471
EP 1493
DI 10.1111/iwj.13744
EA JAN 2022
PG 23
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 4T2LH
UT WOS:000745720900001
PM 35048527
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hao, ZW
   Tian, S
   Hu, CQ
   Jia, Y
AF Hao, Zhiwei
   Tian, Shan
   Hu, Changqing
   Jia, Yan
TI Clinical application of retrograde sural neurofasciocutaneous flap
   repair combined with jingulian capsules to treat foot and ankle soft
   tissue defects
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Retrograde sural neurofasciocutaneous flap repair; Jingulian capsules;
   Soft tissue defect in the foot and ankle; Combination therapy
ID VENO-FASCIOCUTANEOUS FLAP; COMPLICATED SKIN; ANATOMICAL BASIS;
   INFECTIONS
AB Objectives: To observe and analyse the efficacy of retrograde sural neurofasciocutaneous flap repair combined with Jingulian capsules to treat foot and ankle soft tissue defects. Methods: One hundred and eighty patients with foot and ankle soft tissue defects were enrolled in the study from January 2016 to June 2019 in The Second Department of General Surgery,Baoding First Central Hospital. They were divided into a study group and a reference group with the same case number. The former group was provided combination treatment, i.e. retrograde sural neurofasciocutaneous flap repair combined with Jingulian capsules; the latter group was given vacuum sealing drainage. Then, the treatment outcomes of the two groups were compared. Results: The study group needed fewer dressing changes, less preoperative preparation time and antibiotic use than the reference group, p< 0.05. The study group had a significantly lower incidence of wound infections and flap necrosis than the reference group, p< 0.05. The study group was significantly superior to the reference group regarding ankle function scores and the pain visual analogue scores (VAS) p< 0.05. Conclusions: Retrograde sural neurofasciocutaneous flap repair combined with Jingulian capsules is a protocol that improves efficacy for soft tissue defects in the foot and ankle, which are worthy of promotion and practice.
C1 [Hao, Zhiwei] Baoding First Cent Hosp, Dept Gen Surg 2, Baoding 071000, Hebei, Peoples R China.
   [Tian, Shan] Baoding First Cent Hosp, Med Imaging Dept, Baoding 071000, Hebei, Peoples R China.
   [Hu, Changqing] Baoding First Cent Hosp, Orthopaed Dept 5, Baoding 071000, Hebei, Peoples R China.
   [Jia, Yan] Baoding First Cent Hosp, Phys Examinat, Baoding 071000, Hebei, Peoples R China.
RP Hao, ZW (通讯作者)，Baoding First Cent Hosp, Dept Gen Surg 2, Baoding 071000, Hebei, Peoples R China.
EM zhiwei197812@163.com
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NR 20
TC 5
Z9 5
U1 0
U2 6
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
EI 1681-715X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD JAN-FEB
PY 2022
VL 38
IS 1
BP 190
EP 194
DI 10.12669/pjms.38.1.4546
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YL4AY
UT WOS:000745836400033
PM 35035424
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, Q
   Zhang, X
   Sun, WT
   Li, H
AF Wang, Quan
   Zhang, Xu
   Sun, Wentao
   Li, Hua
TI Clinical study on vacuum assisted closure combined with multiple flaps
   in the treatment of severe hand trauma
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Flap treatment; Vacuum assisted closure; Severe hand trauma; Survival
   rate
ID TISSUE; THERAPY
AB Objectives: To investigate the effect and clinical value of the application of vacuum assisted closure (VAC) combined with multiple flaps in the treatment of severe hand trauma. Methods: A total of 100 patients with severe hand trauma admitted to Harrison International Peace Hospital from September 2015 to September 2020 were selected and randomly divided into two groups according to the randomized block method: the single flap repair group and the combined repair group, with 50 patients in each group. Patients in the single flap repair group underwent flap repair according to their condition, while those in the combined repair group were treated with VAC prior to flap repair. The range of motion and hand sensation scores were compared between the two groups, and their levels of interleukin-8 (IL-8), tumor necrosis factor (TNF) and lipopolysaccharide (LPS) were tested by enzyme-linked immunosorbent assay (ELIS). Moreover, the flap survival rate and the incidence of adverse events were recorded and compared between the two groups. Results: Compared with the single flap repair group, the combined repair group had higher range of motion and hand sensation score (p<0.05), lower levels of IL-8, TNF and LPS (p<0.05), higher flap survival rate (p<0.05), and lower incidence of adverse events (p<0.05). Conclusion: VAC combined with multiple flaps boasts significant trauma repair effect and preferable clinical application value in the treatment of patients with severe hand trauma, which is principally reflected in significantly improving the hand function of patients and remarkably alleviating the inflammatory response of patients.
C1 [Zhang, Xu] Orthoped Hosp Sichuan Prov, Dept Orthoped, Chengdu 610041, Sichuan, Peoples R China.
   [Wang, Quan; Sun, Wentao; Li, Hua] Harrison Int Peace Hosp, Dept Hand & Foot Surg, Hengshui 053000, Hebei, Peoples R China.
RP Wang, Q (通讯作者)，Harrison Int Peace Hosp, Dept Hand & Foot Surg, Hengshui 053000, Hebei, Peoples R China.
EM has_rm_hyszwk@126.com
FU Hebei Medical Science Research Project [2019774]
FX The study was sponsored by Hebei Medical Science Research Project
   (No.2019774).
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NR 23
TC 4
Z9 9
U1 0
U2 5
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
EI 1681-715X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD JAN-FEB
PY 2022
VL 38
IS 1
BP 248
EP 253
DI 10.12669/pjms.38.1.4631
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YL4AY
UT WOS:000745836400043
PM 35035434
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Piroski, V
   Mueller, E
   Herrmann, E
   Hanisch, E
   Buia, A
AF Piroski, Vladimir
   Mueller, Elisa
   Herrmann, Eva
   Hanisch, Ernst
   Buia, Alexander
TI Reducing Surgical Site Infection by Prophylactic Negative Pressure Wound
   Therapy in a Cohort of General Surgery Patients
SO VISCERAL MEDICINE
LA English
DT Article
DE Negative pressure wound therapy; Surgical site infection; Simon design
ID PREVENTION; LAPAROTOMY; GUIDELINE; TRIAL; RISK
AB Background: Surgical site infection (SSI) is one of the leading complications in health care. Negative pressure wound therapy (NPWT) is meanwhile widely prophylactically used for preventing SSIs. For evaluating the results of the implantation of this technique, we used the Simon single-arm study design and examine whether NPWT has a prophylactic effect on reducing SSIs in a cohort of general surgery patients. Methods: This single-arm, two-stage study includes 81 elective general surgery patients and corresponds to the Simon's design. The sample size calculation was based on a reduction in the superficial SSI rate from 12 to 4% (power 80%, significance level 5%) using a NPWT system. In compliance with Simon's two-Stage design, the study required the recruitment of 34 patients in stage I and 47 patients in stage II. The two-stage design method would be discarded in case of a wound infection in 3 or more patients in stage I or 6 or more patients in stage II. Using the NPWT system in the operating room, a negative pressure wound dressing was applied post-operatively and removed after 7 days. According to the criteria of the Centres for Disease Control and Prevention (CDC), post-operative wound documentation followed on day 7 and 30. Results: In stage I, no SSI was apparent. In stage II, 3 patients had SSIs (CDC grade I). Conclusion: A prophylactic NPWT can significantly reduce the wound infection rate in elective general surgery.
C1 [Piroski, Vladimir; Hanisch, Ernst; Buia, Alexander] Asklepios Klin Langen, Dept Gen Visceral & Thorac Surg, Langen, Germany.
   [Mueller, Elisa] Goethe Univ Frankfurt, Dept Internal Med, Frankfurt, Germany.
   [Herrmann, Eva] Goethe Univ Frankfurt, Dept Biostat & Math Modeling, Frankfurt, Germany.
C3 Goethe University Frankfurt; Goethe University Frankfurt
RP Buia, A (通讯作者)，Asklepios Klin Langen, Dept Gen Visceral & Thorac Surg, Langen, Germany.
EM a.buia@t-online.de
RI Herrmann, Eva/E-8215-2010
OI Herrmann, Eva/0000-0002-0662-6675; Buia, Alexander/0000-0002-8090-5453
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NR 34
TC 0
Z9 0
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2297-4725
EI 2297-475X
J9 VISC MED
JI Visc. Med.
PD AUG
PY 2022
VL 38
IS 4
BP 272
EP 281
DI 10.1159/000520464
EA JAN 2022
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 3V8DO
UT WOS:000745851000001
PM 36160821
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Eniko, S
   Nándor, L
   Annamária, B
   Erika, S
   László, S
   János, A
   Gábor, C
AF Eniko, Szucs
   Nandor, Lukacs
   Annamaria, Budai
   Erika, Seres
   Laszlo, Sikorszki
   Janos, Argyelin
   Gabor, Cserni
TI Actinomycosis mimicking urachal cancer
SO ORVOSI HETILAP
LA English
DT Article
DE actinomycosis; urachus; neoplasm; differential diagnosis
AB Tumours and other diseases of the urachus are rare. A 67-year-old male presented with a history of recurrent urinary tract infection and ciprofloxacin therapy. Cystoscopy suggested secondary involvement of the bullous upper bladder wall. The subsequent CT-based diagnosis was of a tumour infiltrating the lower median abdominal wall, the urinary bladder and bowels. Bowel obstruction developed and this led to partial resection of the involved organs along with a Hartmann's procedure. Histology revealed no neoplastic conditions, but proved abdominal actinomycosis of probable urachal origin based on the location of the tumour-like lesion and umbilical discharge among the symptoms. Urachal remnants were not identified in the perivesical tissues involved by the microabscess forming inflammation. Amoxicillin therapy was initiated. After a temporary urine leakage from the bladder, the patient became symptomless and was emitted from hospital. After 13 days, he was readmitted because of abdominal wound disruption, which was treated with negative-pressure wound therapy before the abdomen could be closed. At the time of reporting, he is still on amoxicillin, and has become symptomless again. Actinomycosis should be considered in the differential diagnosis of mass lesions of the urachal region.
C1 [Eniko, Szucs] Bacs Kiskun Megyei Oktatokorhaz, Kozponti Radiol Osztaly, Kecskemet, Hungary.
   [Nandor, Lukacs] Bacs Kiskun Megyei Oktatokorhaz, Urol Osztaly, Kecskemet, Hungary.
   [Annamaria, Budai] Bacs Kiskun Megyei Oktatokorhaz, Gasztroenterol Osztaly, Kecskemet, Hungary.
   [Erika, Seres] Bacs Kiskun Megyei Oktatokorhaz, Kozponti Klin Lab, Kecskemet, Hungary.
   [Laszlo, Sikorszki] Bacs Kiskun Megyei Oktatokorhaz, Altalanos Sebeszeti Osztaly, Kecskemet, Hungary.
   [Janos, Argyelin; Gabor, Cserni] Bacs Kiskun Megyei Oktatokorhaz, Patol Osztaly, Kecskemet, Hungary.
   [Gabor, Cserni] Szegedi Tud Egyet, Szent Gyorgyi Albert Klin KOzpont, Altalanos Orvostud Kar, Patol Int, Szeged, Hungary.
C3 Szeged University
RP Gábor, C (通讯作者)，Nyiri Ut 38, H-6000 Kecskemet, Hungary.
EM cserni@freemail.hu
RI Cserni, Gabor/JCN-6784-2023
CR Biró A, 2021, ORVOSI HETILAP, V162, P116, DOI 10.1556/650.2021.31975
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NR 12
TC 1
Z9 1
U1 0
U2 1
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0030-6002
EI 1788-6120
J9 ORVOSI HETILAP
JI Orvosi Hetilap
PD JAN
PY 2022
VL 163
IS 4
BP 157
EP 160
DI 10.1556/650.2022.32325
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YN1TA
UT WOS:000747046500005
PM 35066489
OA Green Accepted, hybrid
DA 2026-07-24
ER
PT J
AU Niimi, Y
   Baba, K
   Tsuchida, M
   Takeda, A
AF Niimi, Yuta
   Baba, Kyoko
   Tsuchida, Masako
   Takeda, Akira
TI A Histological Evaluation of Artificial Dermal Scaffold Used in
   Micrograft Treatment: A Case Study of Micrograft and NPWT Performed on a
   Postoperative Ulcer Formation after Tumor Resection
SO MEDICINA-LITHUANIA
LA English
DT Article
DE micrograft; artificial dermis; negative pressure wound therapy; skin
   ulcer; histological evaluation
AB Background and Objectives: Wound healing (WH) is a complex natural process: the achieving of a proper WH with standard therapies sometimes is not fulfilled and it is often observed in aged and diabetic patients, leading to intractable ulcers. In recent years, autologous micrograft (AMG) therapies have become a new, effective, and affordable wound care strategy among both researchers and clinicians. In this study, a 72-year-old female patient underwent a combination of treatments using micrograft and negative pressure wound therapy (NPWT) on a postoperative skin ulcer after a benign tumor resection on the back with the aim to present an innovative method to treat skin ulceration using AMG combined with an artificial dermal scaffold and NPWT. Materials and Methods: A section of the artificial dermal scaffold, infused with micrografts, was sampled prior to transplant, and sections were collected postoperatively on days 3 and 7. Hematoxylin-eosin (HE) and immunohistochemical stains were employed for the evaluation of Cytokeratin AE1/AE3, desmin, and Factor VIII. Additionally, on postoperative day 3, NPWT dressing was evaluated using HE stains, as well. The resulting HE and immunostaining analysis revealed red blood cells and tissue fragments within the collagen layers of the artificial dermis prior to transplant. On postoperative day 3, collagen layers of the artificial dermis revealed red blood cells and neutrophils based on HE stains, and scattering of cytokeratin AE1/AE3-positive cells were detected by immunostaining. The HE stains on postoperative day 7 showed more red blood cells and neutrophils within the collagen layers of the artificial dermis than on day 3, an increase in cytokeratin AE1/AE3-positive cells, and tissue stained positively with desmin and Factor VIII. Results: Results suggest that the effects of both micrografts and migratory cells have likely accelerated the wound healing process. Furthermore, the NPWT dressing on day 3 showed almost no cells within the dressing. This indicated that restarting NPWT therapy immediately after micrograft transplant did not draw out cells within the scaffold. Conclusions: Micrograft treatment and NPWT may serve to be a useful combination therapy for complex processes of wound healing.
C1 [Niimi, Yuta; Baba, Kyoko; Tsuchida, Masako; Takeda, Akira] Kitasato Univ, Med Ctr, Dept Plast Surg, Saitama 3648501, Japan.
   [Niimi, Yuta; Baba, Kyoko; Tsuchida, Masako; Takeda, Akira] Kitasato Univ, Sch Med, Dept Plast & Aesthet Surg, Sagamihara, Kanagawa 2520373, Japan.
C3 Kitasato University; Kitasato University
RP Baba, K (通讯作者)，Kitasato Univ, Med Ctr, Dept Plast Surg, Saitama 3648501, Japan.; Baba, K (通讯作者)，Kitasato Univ, Sch Med, Dept Plast & Aesthet Surg, Sagamihara, Kanagawa 2520373, Japan.
EM y.niimi@kitasato-u.ac.jp; kyokobaba@med.kitasato-u.ac.jp;
   masako19@kitasato-u.ac.jp; takeda@kitasato-u.ac.jp
OI BABA, Kyoko/0000-0002-6069-7044; Niimi, Yuta/0000-0003-1458-4214
FU Grants-in-Aid for Scientific Research [20K09871] Funding Source: KAKEN
CR Andreone A., 2021, RECONSTRUCTION SCALP, P58
   [Anonymous], 1939, SURG GYNECOL OBSTET
   Astarita C, 2020, J INT MED RES, V48, DOI 10.1177/0300060520914794
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NR 19
TC 8
Z9 8
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JAN
PY 2022
VL 58
IS 1
AR 73
DI 10.3390/medicina58010073
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YN5OE
UT WOS:000747307000001
PM 35056381
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Veerasubramanian, PK
   Joe, VC
   Liu, WYF
   Downing, TL
AF Veerasubramanian, Praveen Krishna
   Joe, Victor C.
   Liu, Wendy F.
   Downing, Timothy L.
TI Characterization of Macrophage and Cytokine Interactions with
   Biomaterials Used in Negative-Pressure Wound Therapy
SO BIOENGINEERING-BASEL
LA English
DT Article
DE macrophages; negative-pressure wound therapy; wound healing; wound
   dressings; cell-material interactions
AB Macrophages are innate immune cells that help wounds heal. Here, we study the potential immunomodulatory effects of negative-pressure wound therapy (NPWT) materials on the macrophage inflammatory response. We compared the effects of two materials, Granufoam (TM) (GF) and Veraflo Cleanse (TM) (VC), on macrophage function in vitro. We find that both materials cause reduced expression of inflammatory genes, such as TNF and IL1B, in human macrophages stimulated with bacterial lipopolysaccharide (LPS) and interferon-gamma (IFN gamma). Relative to adherent glass control surfaces, VC discourages macrophage adhesion and spreading, and may potentially sequester LPS/IFN gamma and cytokines that the cells produce. GF, on the other hand, was less suppressive of inflammation, supported macrophage adhesion and spreading better than VC, and sequestered lesser quantities of LPS/IFN gamma in comparison to VC. The control dressing material cotton gauze (CT) was also immunosuppressive, capable of TNF-alpha retention and LPS/IFN gamma sequestration. Our findings suggest that NPWT material interactions with cells, as well as soluble factors including cytokines and LPS, can modulate the immune response, independent of vacuum application. We have also established methodological strategies for studying NPWT materials and reveal the potential utility of cell-based in vitro studies for elucidating biological effects of NPWT materials.
C1 [Veerasubramanian, Praveen Krishna; Liu, Wendy F.; Downing, Timothy L.] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA.
   [Veerasubramanian, Praveen Krishna; Liu, Wendy F.; Downing, Timothy L.] Univ Calif Irvine, UCI Edwards Lifesci Fdn Cardiovasc Innovat & Res, Irvine, CA 92697 USA.
   [Joe, Victor C.] Univ Calif Irvine, Dept Surg, Irvine, CA 92697 USA.
   [Liu, Wendy F.] Univ Calif Irvine, Dept Chem & Biomol Engn, Irvine, CA 92697 USA.
   [Liu, Wendy F.] Univ Calif Irvine, Inst Immunol, Irvine, CA 92697 USA.
   [Liu, Wendy F.] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA.
   [Downing, Timothy L.] Univ Calif Irvine, NSF Simons Ctr Multiscale Cell Fate Res, Irvine, CA 92697 USA.
   [Downing, Timothy L.] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine
RP Liu, WYF; Downing, TL (通讯作者)，Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA.; Liu, WYF; Downing, TL (通讯作者)，Univ Calif Irvine, UCI Edwards Lifesci Fdn Cardiovasc Innovat & Res, Irvine, CA 92697 USA.; Liu, WYF (通讯作者)，Univ Calif Irvine, Dept Chem & Biomol Engn, Irvine, CA 92697 USA.; Liu, WYF (通讯作者)，Univ Calif Irvine, Inst Immunol, Irvine, CA 92697 USA.; Liu, WYF (通讯作者)，Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA.; Downing, TL (通讯作者)，Univ Calif Irvine, NSF Simons Ctr Multiscale Cell Fate Res, Irvine, CA 92697 USA.; Downing, TL (通讯作者)，Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA.
EM pveerasu@uci.edu; vcjoe@hs.uci.edu; wendy.liu@uci.edu;
   tim.downing@uci.edu
RI ; Veerasubramanian, Praveen Krishna/KIJ-2060-2024
OI Liu, Wendy/0000-0002-8904-7643; Veerasubramanian, Praveen
   Krishna/0000-0001-8204-088X; Downing, Timothy/0000-0002-5197-3684
FU National Institutes of Health (NIH) National Institute of Allergy and
   Infectious Disease (NIAID) [R01AI151301]; NIH National Institute of
   Biomedical Imaging and Bioengineering (NIBIB) [R21EB027840-01]; NIH New
   Innovator Award (DP2) [DP2CA250382-01]; National Science Foundation
   (NSF) grant [DMS1763272]; Simons Foundation [594598 QN];  [DMR-2011967];
    [CHE-0802913];  [1S10OD025064-01A1]
FX This work was supported by National Institutes of Health (NIH) National
   Institute of Allergy and Infectious Disease (NIAID) Grant R01AI151301 to
   W.F.L, NIH National Institute of Biomedical Imaging and Bioengineering
   (NIBIB) Grant R21EB027840-01 to T.L.D and W.F.L, and NIH New Innovator
   Award (DP2) Grant DP2CA250382-01, a National Science Foundation (NSF)
   grant (DMS1763272) and a grant from the Simons Foundation (594598 QN) to
   T.L.D.
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NR 35
TC 5
Z9 8
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2306-5354
J9 BIOENGINEERING-BASEL
JI Bioengineering-Basel
PD JAN
PY 2022
VL 9
IS 1
AR 2
DI 10.3390/bioengineering9010002
PG 14
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA YO7IJ
UT WOS:000748110000001
PM 35049711
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sahin, MF
   Yazicioglu, A
   Beyoglu, MA
   Yekeler, E
AF Sahin, Mehmet Furkan
   Yazicioglu, Alkin
   Beyoglu, Muhammet Ali
   Yekeler, Erdal
TI Successful method in the treatment of complicated sternal dehiscence and
   mediastinitis: Sternal reconstruction with osteosynthesis system
   supported by vacuum-assisted closure
SO TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND
   CARDIOVASCULAR SURGERY
LA English
DT Article
DE Mediastinitis; sternal dehiscence; sternal reconstruction
ID RISK-FACTORS; STERNOTOMY; MANAGEMENT; WOUNDS
AB Background: This study aims to evaluate the results of the method we used to treat sternal dehiscence and mediastinitis due to median sternotomy following open heart surgery. Methods: Between July 2014 and March 2019, a total of 13 patients (8 males, 5 females; mean age: 60.3 +/- 2.9 years; range, 33 to 74 years) who underwent sternal reconstruction procedure and developed sternal dehiscence and mediastinitis after cardiac surgery were retrospectively analyzed. Data of the patients were retrieved from the hospital records. Results: Before the procedure, reconstruction was performed by using the Robiscek technique in three cases and a conventional rewiring technique was used in one case. Except for one case, all the other cases had sternal purulent discharge (n=12, 92%). Except for four cases, all cases had at least two fracture lines in the sternum (n=9, 69%). One to 10 sessions of (median=4) vacuum-assisted closure therapy were used in cases before the procedure. At least two bars were placed between the opposite ribs for sternal fixation. Except for three cases, all of the cases were placed transdiaphragmatic harvested omentum in the sternal cavity. Seroma and local infection recurrence occurred in two cases (n=2, 15.3%) and incisional hernia in one case (n=1, 7.6%). Thoracic stabilization was successfully achieved in all cases. Conclusion: Thoracic stabilization can be successfully achieved in complicated sternal dehiscence cases with sternal reconstruction with STRATOS system supported by vacuum-assisted closure therapy, until the culture turns negative in the preoperative period and by the use of transdiaphragmatic omentum intraoperatively inside the sternal cavity.
C1 [Sahin, Mehmet Furkan; Yazicioglu, Alkin; Beyoglu, Muhammet Ali; Yekeler, Erdal] Hlth Sci Univ, Ankara City Hosp, Dept Thorac Surg & Lung Transplantat, Ankara, Turkey.
C3 University of Health Sciences Turkey; City Hospital Ankara
RP Sahin, MF (通讯作者)，Ankara Sehir Hastanesi, Gogus Cerrahisi & Akciger Nakli Klin, TR-06800 Ankara, Turkey.
EM mfurys@hotmail.com
RI YEKELER, ERDAL/GQP-6086-2022; Şahin, Mehmet Furkan/GOH-0195-2022;
   Beyoglu, Muhammet Ali/ABH-2274-2021
OI Şahin, Mehmet Furkan/0000-0002-7652-624X; Beyoglu, Muhammet
   Ali/0000-0003-4038-630X
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NR 24
TC 3
Z9 5
U1 0
U2 2
PU BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
PI ATASEHIR
PA ORNEK MH DR SUPHI EZGI SK SARAY APT NO 11 D 6, ATASEHIR, ISTANBUL 34704,
   TURKEY
SN 1301-5680
J9 TURK GOGUS KALP DAMA
JI Turk Gogus Kalp Damar Cerrahisi Derg.
PD JAN
PY 2022
VL 30
IS 1
BP 57
EP 65
DI 10.5606/tgkdc.dergisi.2022.2095
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA YQ9LG
UT WOS:000749623900002
PM 35444857
DA 2026-07-24
ER
PT J
AU Gotlin, MJ
   Catalano, W
   Levine, JP
   Egol, KA
AF Gotlin, Matthew J.
   Catalano, William
   Levine, Jamie P.
   Egol, Kenneth A.
TI Wound Closure Following Intervention for Closed Orthopedic Trauma
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE Surgical site infection; Wound closure; Staples; Sutures; Wound healing
ID SURGICAL-SITE INFECTION; POVIDONE-IODINE SOLUTION; ANKLE FRACTURES;
   RISK-FACTORS; LOWER-LIMB; THERAPY; SURGERY; PREVENTION; MANAGEMENT; SKIN
AB The method of skin closure and post-operative wound management has always been important in orthopedic surgery and plays an even larger role now that surgical site infection (SSI) is a national healthcare metric for both surgeons and hospitals. Wound related issues remain some of the most feared complications following orthopedic trauma procedures and are associated with significant morbidity. In order to minimize the risk of surgical site complications, surgeons must be familiar with the physiology of wound healing as well as the patient and surgical factors affecting healing potential. The goal of all skin closure techniques is to promote rapid healing with acceptable cosmesis, all while minimizing risk of infection and dehiscence. Knowledge of the types of closure material, techniques of wound closure, surgical dressings, negative pressure wound therapy, and other local modalities is important to optimize wound healing. There is no consensus in the literature as to which closure method is superior but the available data can be used to make informed choices. Although often left to less experienced members of the surgical team, the process of wound closure and dressing the wound should not be an afterthought, and instead must be part of the surgical plan. Wounds that are in direct communication with bony fractures are particularly at risk due to local tissue trauma, resultant swelling, hematoma formation, and injured vasculature. (c) 2021 Elsevier Ltd. All rights reserved.
C1 [Gotlin, Matthew J.; Catalano, William; Egol, Kenneth A.] NYU Langone Hlth, NYU Langone Orthoped Hosp, Dept Orthoped Surg, 301 East 17th St, New York, NY 10003 USA.
   [Levine, Jamie P.] NYU Langone Hlth, Dept Plast Surg, 222 East 41st St, New York, NY 10017 USA.
C3 NYU Langone Medical Center; NYU Langone Medical Center
RP Gotlin, MJ (通讯作者)，NYU Langone Hlth, NYU Langone Orthoped Hosp, Dept Orthoped Surg, 301 East 17th St, New York, NY 10003 USA.
EM matt.gotlin@gmail.com
OI Levine, Jamie/0009-0009-6163-8490
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NR 77
TC 5
Z9 6
U1 0
U2 16
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2022
VL 53
IS 2
BP 313
EP 322
DI 10.1016/j.injury.2021.11.062
EA JAN 2022
PG 10
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA YR2AD
UT WOS:000749798400015
PM 34865820
DA 2026-07-24
ER
PT J
AU Putri, IL
   Adzalika, LB
   Pramanasari, R
   Wungu, CDK
AF Putri, Indri Lakhsmi
   Adzalika, Lavonia Berlina
   Pramanasari, Rachmaniar
   Wungu, Citrawati Dyah Kencono
TI Negative pressure wound therapy versus conventional wound care in cancer
   surgical wounds: A meta-analysis of observational studies and randomised
   controlled trials
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE cancer wound; malignant wound; medical care; negative pressure wound
   therapy; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; SITE INFECTIONS;
   HIGH-RISK; LAPAROTOMY; PREVENTION; SURGERY; CHALLENGES; MANAGEMENT;
   QUALITY
AB The application of negative pressure wound therapy (NPWT) in cancer surgical wounds is still controversial, despite its promising usage, because of the risks of increased tumorigenesis and metastasis. This study aimed to review the risks and benefits of NPWT in surgical wounds with the underlying malignant disease compared with conventional wound care (CWC). The first outcome was wound complications, divided into surgical site infection (SSI), seroma, hematoma, and wound dehiscence. The secondary outcome was hospital readmission. We performed a separate meta-analysis of observational studies and randomised controlled trials (RCTs) with CI 95%. Thirteen observational studies with 1923 patients and seven RCTs with 1091 patients were included. NPWT group showed significant decrease in the risk of SSI (RR = 0.45) and seroma (RR = 0.61) in observational studies with P value <0.05, as well as RCTs but were not significant (RR = 0.88 and RR = 0.68). Wound dehiscence (RR = 0.74 and RR = 1.15) and hospital readmission (RR = 0.90 and RR = 0.62) showed lower risks in NPWT group but were not significant. Hematoma (RR = 1.08 and RR = 0.87) showed no significant difference. NPWT is not contraindicated in cancer surgical wounds and can be considered a beneficial palliative treatment to promote wound healing.
C1 [Putri, Indri Lakhsmi] Airlangga Univ, Dept Plast Reconstruct & Aesthet Surg, Fac Med, Surabaya, East Java, Indonesia.
   [Putri, Indri Lakhsmi; Adzalika, Lavonia Berlina; Pramanasari, Rachmaniar] Airlangga Univ Hosp, Plast Reconstruct & Aesthet Surg Unit, Surabaya, Indonesia.
   [Wungu, Citrawati Dyah Kencono] Airlangga Univ, Fac Med, Dept Physiol & Med Biochem, Surabaya, Indonesia.
C3 Airlangga University; Airlangga University; Airlangga University
RP Putri, IL (通讯作者)，Airlangga Univ, Dept Plast Reconstruct & Aesthet Surg, Fac Med, Surabaya, East Java, Indonesia.
EM indrilakhsmiputri@fk.unair.ac.id
RI Wungu, Citrawati/ABH-8147-2020; Putri, Indri Lakhsmi/AAD-1393-2022
OI Pramanasari, Rachmaniar/0000-0001-5374-5645; Putri, Indri
   Lakhsmi/0000-0001-6668-6496
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NR 56
TC 10
Z9 12
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2022
VL 19
IS 6
BP 1578
EP 1593
DI 10.1111/iwj.13756
EA FEB 2022
PG 16
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 4T2LH
UT WOS:000749894600001
PM 35112467
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tereshenko, V
   Schweizer, R
   Waldner, M
   Kim, BS
   Giovanoli, P
   Klein, HJ
AF Tereshenko, Vlad
   Schweizer, Riccardo
   Waldner, Matthias
   Kim, Bong-Sung
   Giovanoli, Pietro
   Klein, Holger Jan
TI Outcome Comparison of Different Reconstructive Approaches for Axillary
   Defects Secondary to Radical Excision of Hidradenitis Suppurativa
SO DERMATOLOGY
LA English
DT Article
DE Hidradenitis suppurativa; Axillary defect; Axillary reconstruction;
   Split-thickness skin graft; Posterior arm flap
ID POSTERIOR ARM FLAP; SURGICAL-TREATMENT; MANAGEMENT; COMPLICATIONS
AB Background: Radical excision of debilitating hidradenitis suppurativa lesions is the only curative approach in the advanced stages of the disease. Different concepts for axillary reconstruction do exist, but data on their clinical outcome are scarce. Methods: This is a retrospective cohort study of two reconstructive methods (posterior arm flap vs. vacuum-assisted closure [VAC] + split-thickness skin graft [STSG]) for axillary defects in patients with severe axillary hidradenitis suppurativa treated at the University Hospital Zurich between 2005 and 2020. Results: A total of 35 patients (mean age 36 +/- 10 years, mean BMI 29 +/- 5 kg/m(2), Hurley stage II-III) with 67 operated axillae were stratified according to their type of reconstruction. Median operation time in the flap group was 144 min (IQR 114-207) (cumulative 181 min [IQR 124-300]) and 50 min (IQR 40-81) in the VAC + STSG group (cumulative 151 min [IQR 94-194], p < 0.01; p = 0.20 [cumulative time]). The cumulative length of stay was 6 +/- 3 days in the flap group and 14 +/- 7 days in the VAC + STSG group (p < 0.01). Time to complete wound healing was 27 days (IQR 20-49) in the flap group and 62 days (IQR 41-75) in the VAC + STSG group (p < 0.01). Vancouver Scar Scale score was 6 (IQR 4-9) in the flap group and 11 (IQR 9-12) in the VAC + STSG group (p < 0.01). Protective sensory recovery was most satisfactory in the flap group (p < 0.01). Forty-four percent of patients of the VAC + STSG group demonstrated functional impairment of arm abduction. Time to return to work was less in group A with 42 days (IQR 27-57) needed as compared to group B with 48 days (IQR 34-55) needed (p = 0.32). The average cost saving was 25% higher for the flap group than for the VAC + STSG group. Conclusion: Despite an increased operation time, axillary reconstruction by the posterior arm flap yields a reduced length of stay, less time to complete wound healing along with restoration of a protective sensibility, and less axillary scarring avoiding functional deficits - eventually allowing earlier return to work.
C1 [Tereshenko, Vlad; Schweizer, Riccardo; Waldner, Matthias; Kim, Bong-Sung; Giovanoli, Pietro] Univ Zurich Hosp, Dept Plast Surg & Hand Surg, Zurich, Switzerland.
   [Tereshenko, Vlad] Med Univ Vienna, Dept Plast Reconstruct & Aesthet Surg, Clin Lab Bion Extrem Reconstruct, Vienna, Austria.
   [Klein, Holger Jan] Kantonsspital Aarau, Dept Plast Surg & Hand Surg, Aarau, Switzerland.
   [Klein, Holger Jan] Univ Zurich, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; Medical University of
   Vienna; Kantonsspital Aarau AG (KSA); University of Zurich
RP Klein, HJ (通讯作者)，Kantonsspital Aarau, Dept Plast Surg & Hand Surg, Aarau, Switzerland.; Klein, HJ (通讯作者)，Univ Zurich, Zurich, Switzerland.
EM holger.klein@ksa.ch
RI Kim, Bong-Sung/AAR-3802-2021; Tereshenko, Vlad/HLH-3336-2023
OI Kim, Bong-Sung/0000-0002-0493-3196; Tereshenko, Vlad/0000-0001-7761-5191
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NR 35
TC 8
Z9 9
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-8665
EI 1421-9832
J9 DERMATOLOGY
JI Dermatology
PD SEP
PY 2022
VL 238
IS 5
BP 851
EP 859
DI 10.1159/000521573
EA JAN 2022
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 6M4PY
UT WOS:000750623900001
PM 35086097
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Locatello, LG
   Licci, G
   Maggiore, G
   Gallo, O
AF Locatello, Luca Giovanni
   Licci, Giuseppe
   Maggiore, Giandomenico
   Gallo, Oreste
TI Non-Surgical Strategies for Assisting Closure of Pharyngocutaneous
   Fistula after Total Laryngectomy: A Systematic Review of the Literature
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE head and neck; fistula; complications; non-surgical treatment;
   otorhinolaryngology
ID BOTULINUM-TOXIN-A; PRESSURE WOUND THERAPY; HYPERBARIC-OXYGEN;
   TRANSDERMAL SCOPOLAMINE; SALIVARY FISTULA; CANCER-PATIENTS; NECK-CANCER;
   ORAL-CAVITY; FREE-FLAP; HEAD
AB Background: Pharyngocutaneous fistula (PCF) is a frequent complication after total laryngectomy, with an incidence of up to 65%. Many conservative or invasive approaches are available and the choice among them is usually made on a case-by-case basis. The aim of the present review is to critically summarize the available evidence of the effectiveness of the non-surgical management of PCF. Methods: A systematic review and a meta-analysis of the literature were conducted, according to the PRISMA guidelines. Studies investigating botulinum toxin therapy, scopolamine transdermal patch, hyperbaric oxygen therapy (HBOT), and negative pressure wound therapy (NPWT) were assessed. Complete fistula closure after the initiation of non-surgical treatment was the main outcome. Results: After the application of selection criteria, a total of seven articles and 27 patients were included in the present review. All the eligible studies were descriptive case series, while only one article used a standard group as a comparison. The mean age was 63.3 and 14 patients (51.9%) had previously received RT. The reported comorbidities were diabetes, ischemic heart disease, hypertension, dyslipidemia, COPD, and atrial fibrillation. With a mean healing time of 25.0 days, the overall success rate was 92.6%. Conclusions: Non-surgical treatment of PCF is only based on the experience of small series. Although success rates seem promising, the absence of properly designed comparative studies does not allow us, at present, to identify ideal candidates for these non-invasive management strategies for PCF.
C1 [Locatello, Luca Giovanni; Licci, Giuseppe; Maggiore, Giandomenico; Gallo, Oreste] Careggi Univ Hosp, Dept Otorhinolaryngol, Largo Brambilla 3, I-50134 Florence, Italy.
   [Gallo, Oreste] Univ Florence, Dept Expt & Clin Med, I-50134 Florence, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi;
   University of Florence
RP Locatello, LG (通讯作者)，Careggi Univ Hosp, Dept Otorhinolaryngol, Largo Brambilla 3, I-50134 Florence, Italy.
EM locatello.lucagiovanni@gmail.com; giuseppe.licci@unifi.it;
   maggiore2@virgilio.it; oreste.gallo@unifi.it
RI Locatello, Luca Giovanni/AAW-1460-2020; Maggiore,
   Giandomenico/AAA-1846-2021
OI Locatello, Luca Giovanni/0000-0002-1879-5580; Gallo,
   Oreste/0000-0003-3426-7179; Maggiore, Giandomenico/0000-0002-2741-4460
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NR 64
TC 22
Z9 26
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN
PY 2022
VL 11
IS 1
AR 100
DI 10.3390/jcm11010100
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YS5ZE
UT WOS:000750753800001
PM 35011841
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gul, MO
   Sunamak, O
   Kina, U
   Gunay, E
   Akyuz, C
AF Gul, M. O.
   Sunamak, O.
   Kina, U.
   Gunay, E.
   Akyuz, C.
TI Fournier's Gangrene: Our Five-Year Series and the Role of
   Vacuum-Assisted Closure in the Treatment
SO NIGERIAN JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
DE Debridement; Fournier's gangrene; mortality; vacuum-assisted closure
ID HYPERBARIC-OXYGEN THERAPY; RETROSPECTIVE ANALYSIS; MANAGEMENT
AB Background: Fournier's Gangrene (FG) is the necrotizing fasciitis of the perineal region. Aims: To compare the effectiveness of debridement alone and debridement with vacuum-assisted closure in the treatment of Fournier's gangrene. Methods: Twenty-two patients operated for FG were analyzed retrospectively. Debridement-only and debridement + VAC treatment groups were compared in terms of age, gender, predisposing factors, comorbid diseases, intensive care unit and hospital stay durations, laboratory results, septic shock, treatment methods, Fournier' gangrene severity index (FGSI) and mortality. Results: The M/F ratio was 13/9. There were 10 and 12 patients in debridement-only and debridement + VAC groups, respectively. Ten patients (45.5%) were admitted to intensive care unit, 8 (36.4%) needed colostomy and 7 (31.9%) developed septic shock, respectively. The mortality rate was 27.3%. There was no significant difference in terms of age, gender, laboratory parameters, number of debridement, length of stay in intensive care unit and hospital, shock duration, and mortality (P > 0.05). The FGSI scores also did not show any difference between the groups which showed that the severity of the disease in both groups are similar. Conclusion: The VAC treatment was found not to provide a statistically significant benefit on mortality. Early and adequate debridement and antibiotic are still the most important factors in the treatment of FG and to reduce mortality.
C1 [Gul, M. O.] Cukurova Univ, Balcali Training & Res Hosp, Dept Surg Oncol, Adana, Turkey.
   [Sunamak, O.; Kina, U.; Gunay, E.; Akyuz, C.] Haydarpasa Numune Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
C3 Cukurova University; Istanbul Haydarpasa Sultan Abdulhamid Training &
   Research Hospital; Istanbul Haydarpasa Numune Training & Research
   Hospital
RP Gul, MO (通讯作者)，Cukurova Univ, Balcali Training & Res Hosp, Dept Surg Oncol, Adana, Turkey.
EM mehmetonurgul@hotmail.com
RI ; Gul, Mehmet Onur/AAB-6045-2021
OI KINA KILIÇASLAN, UMUT/0000-0002-3118-5701; 
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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NR 31
TC 12
Z9 14
U1 1
U2 3
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1119-3077
J9 NIGER J CLIN PRACT
JI Niger. J. Clin. Pract.
PD SEP
PY 2021
VL 24
IS 9
BP 1277
EP 1282
DI 10.4103/njcp.njcp_387_20
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YT4UW
UT WOS:000751358000003
PM 34531337
OA gold
DA 2026-07-24
ER
PT J
AU Ruiz, E
   Moreno, P
   Poveda, DS
   Fernández, AM
   González, FJ
   Algar, FJ
   Cerezo, F
   Baamonde, C
   Salvatierra, A
   Alvarez, A
AF Ruiz, Eloisa
   Moreno, Paula
   Sebastian Poveda, David
   Maria Fernandez, Alba
   Javier Gonzalez, Francisco
   Javier Algar, Francisco
   Cerezo, Francisco
   Baamonde, Carlos
   Salvatierra, Angel
   Alvarez, Antonio
TI Case Report on Sternal Osteomyelitis by Trichosporon inkin
   Complicating Lung Transplantation: Effective Treatment With
   Vacuum-Assisted Closure and Surgical Reconstruction
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article; Proceedings Paper
CT 12th Congress of the
   Andalusian-Society-of-Organ-and-Tissue-Transplantation (SATOT)
CY JUN 09-10, 2021
CL ELECTR NETWORK
SP Andalusian Soc Organ & Tissue Transplantat
ID MEDIASTINITIS; INFECTIONS; HEART
AB Sternal osteomyelitis is a serious complication that significantly increases morbidity and mortality after thoracic surgery. We describe a case of sternal osteomyelitis by Trichosporon inkin following lung transplantation and the excellent results achieved with vacuum-assisted closure therapy.
C1 [Ruiz, Eloisa; Moreno, Paula; Sebastian Poveda, David; Maria Fernandez, Alba; Javier Gonzalez, Francisco; Javier Algar, Francisco; Cerezo, Francisco; Baamonde, Carlos; Salvatierra, Angel; Alvarez, Antonio] Univ Hosp Reina Sofia, Dept Thorac Surg & Lung Transplantat, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
RP Alvarez, A (通讯作者)，Univ Hosp Reina Sofia, Dept Thorac Surg & Lung Transplantat, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
EM aalvarez53@gmail.com
RI /E-4530-2015; Gonzalez, Fernando/AFQ-4244-2022; Alvarez Kindelan,
   Antonio/AAM-6126-2021
OI Fernández González, Alba María/0000-0001-6426-5460; Alvarez Kindelan,
   Antonio/0000-0003-1531-9543
CR Abid Q, 2003, ANN THORAC SURG, V75, P1565, DOI 10.1016/S0003-4975(02)04905-6
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NR 9
TC 5
Z9 6
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD JAN-FEB
PY 2022
VL 54
IS 1
BP 54
EP 56
DI 10.1016/j.transproceed.2021.09.062
EA FEB 2022
PG 3
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Immunology; Surgery; Transplantation
GA YU2FP
UT WOS:000751863500017
PM 34876268
DA 2026-07-24
ER
PT J
AU Hu, CJ
   Lai, Y
   Jiang, YQ
   Wen, T
   Gao, GM
   Li, HB
   Long, H
AF Hu Chia-Jui
   Lai Yu
   Jiang, Yu-qing
   Wen Tan
   Gao, Gong-ming
   Li, Hai-bo
   Long Han
TI Negative pressure wound therapy, artificial skin and autogenous skin
   implantation in diabetic foot ulcers
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE artificial skin; autogenous skin implantation; diabetes; diabetic foot
   ulcer; Integra artificial skin; negative-pressure wound therapy; skin
   transplantation; wound; wound care; wound dressing; wound healing
ID ULCERATION; DERMIS; PREVENTION; AMPUTATION; EFFICACY; GRAFT
AB Objective: Diabetic foot ulcers (DFUs) are one of the most serious diabetic consequences, leading to amputations. Various therapies have been used to treat DFUs; however, a combination of negative pressure suction, artificial skin and autogenous skin implantation have never been investigated. This study aimed to evaluate the effectiveness of a novel three-step therapy protocol using negative pressure wound therapy (NPWT), artificial skin and autogenous skin implantation in patients with DFUs.
   Method: At a single tertiary university hospital between 2015 and 2018, the three-step therapy protocol was applied to patients with DFUs and its safety and efficacy was investigated.
   Results: A total of 21 patients took part in the study. The majority of the patients were female (62%), with a mean age of 65 years and a mean body mass index of 21kg/m(2). A third (n=7) of operative sites experienced minor complications, with two requiring re-operation. At a median follow up of 24 months, the average time of complete wound healing was 46 days, and the wound healing rate was 71%. The first-stage wound healing rate was 90%. All patients had achieved remission without any further recurrence of disease.
   Conclusion: This comprehensive surgical technique for managing DFUs achieved a high local cure rate, minimal functional morbidity, and acceptable wound complication rates. The three-step therapy protocol has the potential to promote the healing process of DFUs, which is expected to serve as a new method for the treatment and cure of DFUs.
C1 [Hu Chia-Jui; Lai Yu; Jiang, Yu-qing] Xiamen ChangGung Hosp, Dept Orthoped, Xiamen, Fujian, Peoples R China.
   [Wen Tan; Gao, Gong-ming; Li, Hai-bo; Long Han] Nanjing Med Univ, Dept Orthoped, Affiliated Changzhou 2 Peoples Hosp, Changzhou City, Jiangsu, Peoples R China.
C3 Nanjing Medical University
RP Long, H (通讯作者)，Nanjing Med Univ, Dept Orthoped, Affiliated Changzhou 2 Peoples Hosp, Changzhou City, Jiangsu, Peoples R China.
EM darksonnight@163.com
RI HAN, LONG/JCO-8258-2023
CR Abd El-Khalik SR, 2020, MICROVASC RES, V130, DOI 10.1016/j.mvr.2020.103987
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NR 43
TC 4
Z9 4
U1 0
U2 28
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2022
VL 31
IS 1
BP 40
EP 46
DI 10.12968/jowc.2022.31.1.40
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA YU4EW
UT WOS:000751999300006
PM 35077212
DA 2026-07-24
ER
PT J
AU Paolini, G
   Sorotos, M
   Firmani, G
   Gravili, G
   Ceci, D
   di Pompeo, FS
AF Paolini, Guido
   Sorotos, Michail
   Firmani, Guido
   Gravili, Gianluca
   Ceci, Diego
   di Pompeo, Fabio Santanelli
TI Low-vacuum negative pressure wound therapy protocol for complex wounds
   with exposed vessels
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE complex wound; exposed vessels; low-vacuum negative pressure wound
   therapy; negative pressure wound therapy; NPWT; treatment protocol;
   wound; wound care; wound dressing; wound healing
ID ASSISTED CLOSURE THERAPY; GROIN; INFECTIONS; GAUZE
AB Objective: Treating high-risk surgical patients with complex wounds over exposed blood vessels is a challenge. Guided wound healing may be the only treatment possible. Negative pressure wound therapy (NPWT) is not recommended in these cases. The authors challenged these current recommendations and share their preliminary experience.
   Method: The authors adapted a NPWT protocol that uses low-vacuum continuous pressure (-80mmHg) with a silicone sheath and gauze/foam dressing between the wound bed and the device. They monitored the clinical features of patients' wounds to detect bleeding/ischaemia early on. Dressings were changed every 72-96 hours.
   Results: This protocol was followed in five male patients (aged 23-68 years) with complex wounds over exposed vessels. Two cases were foot crush injuries, one midfoot amputation, one hand self-subamputation and one vascular bypass infection. Comorbidities included monoarterial limbs/stump, severe arteriopathy and psychiatric disorder. The exposed vessels were femoral, radial and ulnar, anterior and posterior tibial arteries and veins. Mean treatment lasted 37 days (range 20-61 days). No episodes of severe bleeding/ischaemia of the extremities were observed. Treatment was discontinued once debridement was complete and granulation tissue allowed spontaneous closure/grafting. All wounds appeared stable at 1-year follow-up.
   Conclusion: The low-vacuum NPWT protocol was successful in solving five difficult cases. This regimen reduces risks associated with NPWT use on wounds with exposed vessels. The authors believe further validation is required to strengthen the evidence. However, preliminary data are encouraging and might help to change future NPWT recommendations by extending the indications for its use to exposed vessels.
C1 [Paolini, Guido; Firmani, Guido; di Pompeo, Fabio Santanelli] Univ Sapienza Rome, Nesmos Dept, Plast Surg Unit, Fac Med & Psychol, Rome, Italy.
   [Paolini, Guido; Ceci, Diego] St Andrea Hosp Rome, Rome, Italy.
   [Sorotos, Michail] Univ Salerno, PhD Sch Translat Med Dev & Act Aging, Dept Med Surg & Dent, Scuola Med Salernitana, Salerno, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Azienda Ospedaliera
   Sant'Andrea; University of Salerno
RP Paolini, G (通讯作者)，Univ Sapienza Rome, Nesmos Dept, Plast Surg Unit, Fac Med & Psychol, Rome, Italy.; Paolini, G (通讯作者)，St Andrea Hosp Rome, Rome, Italy.
EM guido.paolini@uniroma1.it
RI Firmani, Guido/AAN-4393-2020; SOROTOS, MICHAIL/AAA-9566-2020; paolini,
   guido/F-4707-2012
OI Firmani, Guido/0000-0002-5806-1530; SOROTOS,
   MICHAIL/0000-0002-4822-3794; 
CR Andersson S, 2018, ANN VASC SURG, V48, P104, DOI 10.1016/j.avsg.2017.10.018
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NR 28
TC 7
Z9 9
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2022
VL 31
IS 1
BP 78
EP 85
DI 10.12968/jowc.2022.31.1.78
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA YU4EW
UT WOS:000751999300010
PM 35077217
DA 2026-07-24
ER
PT J
AU Davini, G
   Dini, V
   Janowska, A
   Macchia, M
   Gualtieri, B
   Granieri, G
   Romanelli, M
AF Davini, Giulia
   Dini, Valentina
   Janowska, Agata
   Macchia, Michela
   Gualtieri, Bruno
   Granieri, Giammarco
   Romanelli, Marco
TI Wound Dehiscence After Achilles Tendon Trauma and Repair: Treatment With
   Ultraportable Negative Pressure Wound Therapy and Compression Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE dehiscence; Achilles tendon; trauma; ultraportable; negative pressure
   wound therapy; wound healing
ID VENOUS LEG ULCERS; METAANALYSIS; INFECTIONS; MANAGEMENT
AB Introduction. Achilles tendon rupture is a common injury requiring surgical repair. Re-ruptures, infections, delayed wound healing, and hematomas have been reported postoperatively. Objective. This case series described the use of ultraportable negative pressure wound therapy (NPWT) and compression bandaging following postoperative dehiscence of Achilles tendon repair. Materials and Methods. Retrospective records were reviewed to identify patients who underwent wound management for Achilles tendon dehiscence between January 2014 and January 2018. Patient demographics, wound size at first and last visit, number of visits, and previous treatment data were extracted. Wound management included wound irrigation, surgical debridement, and application of silver dressings, as needed. Therapy was transitioned to ultraportable NPWT with twice-weekly dressing changes. When possible, patients with an ankle-brachial index greater than 0.8 received multilayer, multicomponent compression. Treatment response was evaluated using a wound imaging system at 2-week to 4-week intervals for a total of 24 weeks. Results. Nine male patients with a mean age of 69.7 years presented for care. One patient sustained injury during sports activities, and the other 8 patients sustained injuries resulting from household accidents. Six patients achieved complete wound closure. Three patients achieved a mean 90% wound closure. No adverse effects were observed during treatment with NPWT and compression therapy. Conclusions. In the current study, ultraportable NPWT and compression bandaging were found to be effective in the management of wounds with critical local vascularity. Larger, randomized controlled studies are necessary to fully assess the potential clinical benefit of NPWT and compression therapy in the management of postoperative wounds of the Achilles tendon.
C1 [Davini, Giulia; Dini, Valentina; Janowska, Agata; Macchia, Michela; Granieri, Giammarco; Romanelli, Marco] Univ Pisa, Sch Med & Surg, Dermatol Unit, Pisa, Italy.
   [Gualtieri, Bruno] Venezia Hosp, Dermatol Unit, Venice, Italy.
C3 University of Pisa
RP Romanelli, M (通讯作者)，Univ Pisa, Dept Dermatol, Via Roma 67, I-56126 Pisa, Italy.
EM romanellimarco6o@gmail.com
RI Janowska, Agata/HHS-7036-2022; romanelli, marco/ABI-1154-2020; Granieri,
   Giammarco/ACL-6360-2022; dini, valentina/F-7747-2017
OI Janowska, Agata/0000-0002-2271-3859; romanelli,
   marco/0000-0002-4127-0141; Granieri, Giammarco/0000-0002-6788-3253;
   dini, valentina/0000-0002-8537-1999
CR Arabyat RM, 2015, EXPERT OPIN DRUG SAF, V14, P1653, DOI 10.1517/14740338.2015.1085968
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NR 19
TC 5
Z9 5
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2021
VL 33
IS 12
BP E93
EP E98
DI 10.25270/wnds/2021.e93e98
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA YU9EY
UT WOS:000752339500002
PM 35100134
DA 2026-07-24
ER
PT J
AU Olivia, G
   Petter, L
   Håkan, P
AF Olivia, Grip
   Petter, Lindahl
   Hakan, Parsson
TI Acute Compartment Syndrome Following Thrombolysis For Acute Lower Limb
   Ischemia
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID FASCIOTOMY; DIAGNOSIS; VALIDATION; MANAGEMENT; ARTERIAL; ANEURYSM;
   REGISTRY; SURGERY; LEG
AB Background: Acute Compartment syndrome (ACS) with subsequent need for fasciotomy is a serious and insidious complication after revascularization for acute lower limb ischemia (ALI). The development of ACS during endovascular catheter directed thrombolysis is particularly difficult to identify. The aim was to identify the incidence, predisposing factors, wound treatment, and outcome in terms of amputation and survival for patients presenting with ALI that develop ACS during catheter directed thrombolysis. Patients who did not develop ACS after thrombolysis were analyzed as controls. Methods: Descriptive retrospective analysis of prospective databases from two large tertiaryreferral vascular centers. Patients with ACS after thrombolysis for ALI between 2001-2017 were analyzed. Results: Seventy-eight cases and 621 controls were identified. Mean age was 72 years and 30 (38.5%) were women in the ACS group. Patients that developed ACS presented with significantly more severe preoperative ischemia. With 38.5% having Rutherford 2b classification as compared to 22.7 % in the control group ( P = 0.002). Occluded popliteal arter y aneur ysms were also associated with a higher incidence of ACS ( P = 0.041). Treatment of the fasciotomy wound was most commonly treated with regular wound dressing in 45 (58%) of cases, while wound dressing and foot pump and vacuum assisted closure were used in 14 (18%) and 19 (24%) respectively. These differing approaches did not affect the number of wound infections and amputations, which was similar regardless of treatment type. Vacuum assisted closure was associated with a higher degree of skin graft closure ( P = 0.001). The median time to complete wound closure was 10 days. One year after thrombolysis, the major amputation rate in the ACS group was 31% as opposed to 17% in control group, P = 0.003. Mortality measured at 16.7% and 15.3%, respectively, P = 0.872. Amputation-free survival in the ACS group was 62% vs. 73% in the control group, P = 0.035. These differences level out, however, when applying long-term analysis of amputationfree survival in Kaplan-Meier analysis (log-rank 0.103). Conclusions: Patients that developed ACS during endovascular CDT presented with a more severe pre-operative ischemia, more occluded popliteal arter y aneur ysms and had a higher amputation rate during the first year, compared to controls. The development of ACS during endovascular treatment of ALI with thrombolysis is not uncommon and warrants both clinical awareness and rapid treatment.
C1 [Olivia, Grip] Uppsala Univ, Vasc Surg Sect, Dept Surg Sci, Uppsala, Sweden.
   [Petter, Lindahl] Lund Univ, Dept Clin Sci, Fac Med, Lund, Sweden.
   [Hakan, Parsson] Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.
C3 Uppsala University; Lund University; Linkoping University
RP Håkan, P (通讯作者)，Linkoping Univ, Dept Biomed & Clin Sci, Kalmar Hosp, S-39185 Linkoping, Sweden.
EM hakan.parsson@liu.se
OI pärsson, håkan/0000-0002-6566-8381
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   Troëng T, 2008, EUR J VASC ENDOVASC, V36, P705, DOI 10.1016/j.ejvs.2008.08.017
   Venermo M, 2015, EUR J VASC ENDOVASC, V50, P802, DOI 10.1016/j.ejvs.2015.07.021
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   Zhang DF, 2020, EUR J ORTHOP SURG TR, V30, P359, DOI 10.1007/s00590-019-02563-8
NR 36
TC 13
Z9 14
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD FEB
PY 2022
VL 79
BP 182
EP 190
DI 10.1016/j.avsg.2021.07.015
EA FEB 2022
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA YV1FT
UT WOS:000752478600024
PM 34644632
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hill, R
AF Hill, Richard
TI Using Augmented Reality to Improve Patient Outcomes With Negative
   Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE quality improvement; augmented reality; digital technology; negative
   pressure wound therapy
AB Introduction. Augmented reality (AR) is a burgeoning digital technology that is finding more frequent use in health care. The benefits of AR, such as hands-free imaging and remote viewing, make this a tool particularly suited to wound care. To the author's knowledge, no attempts have been made to leverage this technology in a way that might improve patient outcomes. Similarly, few studies on remote wound consultation focus on the inpatient setting. Objective. This study demonstrated the use of AR to improve the outcome of patients undergoing negative pressure wound therapy. Materials and Methods. A case-control study of 27 patients treated in a rural Louisiana hospital was performed. A retrospective control group (n = 15) was identified and compared with similar cases (n = 12) that used AR by the bedside nursing staff and an offsite certified wound care clinician. Results. At univariate analysis, the treatment group was found to have fewer unintended surgical revisions (P =.002), fewer interruptions in therapy time (P =.01), and fewer readmissions related to wound infection (P =.004) compared with the control group. Correlational testing was performed and showed a significant correlation between the number of dressings performed and the number of complications that arose (0.71) as well as between premature dressing removals and number of readmissions related to infection (0.74). Conclusions. The results of this study, although preliminary, show how AR can be used in the acute care setting to positively influence outcomes of patients undergoing wound care. Further testing is necessary to replicate these findings and assess the use of AR with other advanced modalities or for other indications in the acute care setting.
C1 [Hill, Richard] Natchitoches Reg Med Ctr, 501 Keyser Ave, Natchitoches, LA 71457 USA.
RP Hill, R (通讯作者)，Natchitoches Reg Med Ctr, 501 Keyser Ave, Natchitoches, LA 71457 USA.
EM hill.richardb@gmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bugeja L, 2018, INT WOUND J, V15, P880, DOI 10.1111/iwj.12940
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NR 8
TC 4
Z9 4
U1 0
U2 14
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2022
VL 34
IS 2
BP 47
EP 50
DI 10.25270/wnds/2022.4750
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA YV3YQ
UT WOS:000752667100002
PM 35108668
DA 2026-07-24
ER
PT J
AU Carrano, FM
   Maroli, A
   Carvello, M
   Foppa, C
   Sacchi, M
   Crippa, J
   Clerico, G
   De Lucia, F
   Coppola, E
   Ben David, N
   Spinelli, A
AF Carrano, Francesco M.
   Maroli, Annalisa
   Carvello, Michele
   Foppa, Caterina
   Sacchi, Matteo
   Crippa, Jacopo
   Clerico, Giuseppe
   De Lucia, Francesca
   Coppola, Elisabetta
   Ben David, Nadav
   Spinelli, Antonino
TI Negative-pressure wound therapy after stoma reversal in colorectal
   surgery: a randomized controlled trial
SO BJS OPEN
LA English
DT Article
ID SURGICAL SITE INFECTION; SHORT-TERM OUTCOMES; POSTOPERATIVE
   COMPLICATIONS; ILEOSTOMY CLOSURE; SKIN CLOSURE; RISK-FACTORS; MORBIDITY;
   PREVENTION; RESECTION; DISEASE
AB The use of negative-pressure wound therapy (NPWT) does not reduce the incidence of surgical-site infections after stoma-reversal surgery; however, its application reduces healing times, provides superior comfort for the patient, reduces wound pain and leads to better aesthetic outcomes compared with standard purse-string suture technique. This is the first randomized trial evaluating pain and discomfort with the application of NPWT in stoma reversal.
   Background Stoma-reversal surgery is associated with high postoperative morbidity, including wound complications and surgical-site infections (SSIs). This study aims to assess whether the application of negative-pressure wound therapy (NPWT) can improve wound healing compared with conventional wound dressing. Methods This was a single-centre, superiority, open-label, parallel, individually randomized controlled trial. Patients undergoing stoma reversal were randomized (1 : 1) to receive NPWT or conventional wound dressing. The primary endpoint of the study was the rate of wound complications and SSIs after stoma closure. The secondary endpoints were postoperative wound pain, rate of wound healing after 30 days from stoma closure, and wound aesthetic satisfaction. Results Between June 2019 and January 2021, 50 patients were allocated to the NPWT group (all received NPWT, 49 were analysed); 50 patients were allocated to the conventional wound dressing group (48 received the treatment, 45 were analysed). No significant difference was found in wound-complication rate (10 per cent NPWT versus 16 per cent controls; odds ratio 0.61 (95 per cent c.i. 0.18 to 2.10), P = 0.542) and incisional SSI rate (8 per cent NPWT versus 7 per cent controls; odds ratio 1.24 (95 per cent c.i. 0.26 to 5.99), P = 1.000). The NPWT group showed less pain, higher aesthetic satisfaction (P < 0.0001), and a higher proportion of wound healing (92 versus 78 per cent; P = 0.081) compared with the control group. Conclusion NPWT does not reduce the incidence of SSI after stoma-reversal surgery compared with conventional wound dressing. However, NPWT improved the healing of uninfected wounds, reduced wound pain and led to better aesthetic outcomes. Registration number: NCT037812016 (clinicaltrials.gov).
C1 [Carrano, Francesco M.; Maroli, Annalisa; Carvello, Michele; Foppa, Caterina; Sacchi, Matteo; Crippa, Jacopo; Clerico, Giuseppe; De Lucia, Francesca; Coppola, Elisabetta; Ben David, Nadav; Spinelli, Antonino] Humanitas Univ, Dept Biomed Sci, Milan, Italy.
   [Spinelli, Antonino] IRCCS Humanitas Res Hosp, Div Colon & Rectal Surg, Milan, Italy.
C3 Humanitas University
RP Spinelli, A (通讯作者)，IRCCS Humanitas Res Hosp, Via Manzoni 56, I-20089 Rozzano, MI, Italy.
EM antonino.spinelli@hunimed.eu
RI Carrano, Francesco Maria/AAB-6807-2021; Foppa, Caterina/AAC-2327-2020;
   Crippa, Jacopo/AAC-5116-2019; DE LUCIA, FRANCESCA/LWK-7416-2024; MAROLI,
   ANNALISA/IAR-5529-2023; carvello, michele maria/HHN-5282-2022; SACCHI,
   MATTEO/J-7484-2018; Spinelli, Antonino/ABI-1441-2020
OI MAROLI, ANNALISA/0000-0002-7576-9629; carvello, michele
   maria/0000-0002-8650-2321; SACCHI, MATTEO/0000-0001-8313-4909; Spinelli,
   Antonino/0000-0002-1493-1768
FU SmithNephew S.R.L.
FX This study was funded by Smith&Nephew S.R.L., which provided a research
   grant covering the trial-specific expenses (including patient insurance,
   hosting of the electronic case report form, and NPWT devices).
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NR 32
TC 29
Z9 33
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD NOV 9
PY 2021
VL 5
IS 6
AR zrab116
DI 10.1093/bjsopen/zrab116
EA DEC 2021
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA YW0LP
UT WOS:000753113400035
PM 34904647
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kline, BP
   Jeganathan, NA
AF Kline, Bryan P.
   Jeganathan, Nimalan A.
TI Necrotizing Soft Tissue Infections of the Perineum
SO CLINICS IN COLON AND RECTAL SURGERY
LA English
DT Article
DE necrotizing soft tissue infection; Fournier's gangrene; surgical
   debridement
ID STOMA SITE MARKING; FOURNIERS GANGRENE; HYPERBARIC-OXYGEN; FASCIITIS;
   MANAGEMENT; MORTALITY; OUTCOMES; DETERMINANTS; MULTICENTER; DIAGNOSIS
AB Necrotizing soft tissue infections of the perineum are rapidly progressing infections associated with significant morbidity and mortality. Prompt diagnosis and management with early surgical debridement is necessary to improve survival from this deadly disease. Repeat debridements are not uncommon. Important adjuncts to surgery include broad-spectrum antibiotics and management in an intensive care unit, as patients frequently develop multisystem organ failure. Once the acute phase is managed, fecal diversion with either an ostomy or fecal management catheter can be considered to decrease soiling of the wound and facilitate healing. Long-term management requires meticulous wound care, often with the assistance of negative pressure wound therapy. Patients may ultimately require skin grafts or tissue flaps for soft tissue coverage following extensive surgical debridements.
C1 [Kline, Bryan P.] Penn State Univ, Coll Med, Dept Surg, Hershey, PA 17033 USA.
   [Jeganathan, Nimalan A.] Penn State Univ, Coll Med, Dept Surg, Div Colon & Rectal Surg, 500 Univ Dr, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Jeganathan, NA (通讯作者)，Penn State Univ, Coll Med, Dept Surg, Div Colon & Rectal Surg, 500 Univ Dr, Hershey, PA 17033 USA.
EM njeganathan@pennstatehealth.psu.edu
FU Marshia and Peter Carlino Early Career Professorship at Penn State
   Hershey Medical Center
FX This work was supported by the Marshia and Peter Carlino Early Career
   Professorship at Penn State Hershey Medical Center.
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NR 51
TC 2
Z9 4
U1 1
U2 5
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1531-0043
EI 1530-9681
J9 CLIN COLON RECT SURG
JI Clin. Colon Rectal Surg.
PD MAY
PY 2022
VL 35
IS 03
BP 237
EP 243
DI 10.1055/s-0041-1740102
EA FEB 2022
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 3S5TD
UT WOS:000753152000001
PM 35966380
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Älgå, A
   Löfgren, J
   Haweizy, R
   Bashaireh, K
   Wong, S
   Forsberg, BC
   von Schreeb, J
   Malmstedt, J
AF Alga, Andreas
   Lofgren, Jenny
   Haweizy, Rawand
   Bashaireh, Khaldoon
   Wong, Sidney
   Forsberg, Birger C.
   von Schreeb, Johan
   Malmstedt, Jonas
TI Cost analysis of negative-pressure wound therapy versus standard
   treatment of acute conflict-related extremity wounds within a randomized
   controlled trial
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Trauma; Armed conflict; Wounds; Cost analysis
AB Background Clinical outcomes after negative-pressure wound therapy (NPWT) and standard treatment of conflict-related extremity wounds are similar. In resource-limited settings, cost affects the choice of treatment. We aimed to estimate treatment-related costs of NPWT in comparison with standard treatment for conflict-related extremity wounds. Methods We derived outcome data from a randomized, controlled superiority trial that enrolled adult (>= 18 years) patients with acute (<= 72 h) conflict-related extremity wounds at two civilian hospitals in Jordan and Iraq. Primary endpoint was mean treatment-related healthcare costs (adjusted to 2019 US dollars). Results Patients were enrolled from June 9, 2015, to October 24, 2018. A total of 165 patients (155 men [93.9%]; 10 women [6.1%]; and median [IQR] age, 28 [21-34] years) were included in the analysis. The cost per patient treated with NPWT was $142 above that of standard treatment. Overall, results were robust in a sensitivity analysis. Conclusions With similar clinical outcomes compared to standard care, our results do not support the use of NPWT in routine treatment of conflict-related extremity wounds at civilian hospitals in resource scarce settings. Trial registration NCT02444598.
C1 [Alga, Andreas; Malmstedt, Jonas] Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Sjukhusbacken 10, S-11883 Stockholm, Sweden.
   [Alga, Andreas; Forsberg, Birger C.; von Schreeb, Johan] Karolinska Inst, Dept Global Publ Hlth, S-17177 Stockholm, Sweden.
   [Lofgren, Jenny] Karolinska Inst, Dept Mol Med & Surg, S-17177 Stockholm, Sweden.
   [Haweizy, Rawand] Hawler Med Univ, Coll Med, Erbil 400112, Iraq.
   [Bashaireh, Khaldoon] Jordan Univ Sci & Technol, Dept Special Surg, Irbid 22110, Jordan.
   [Bashaireh, Khaldoon] Yarmouk Univ, Med Fac, Irbid 21163, Jordan.
   [Wong, Sidney] Operat Ctr Amsterdam, Med Sans Frontieres, Plantage Middenlaan 14, NL-1018 DD Amsterdam, Netherlands.
C3 Karolinska Institutet; Sodersjukhuset Hospital; Karolinska Institutet;
   Karolinska Institutet; Hawler Medical University; Jordan University of
   Science & Technology; Yarmouk University; Doctors Without Borders
RP Älgå, A (通讯作者)，Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Sjukhusbacken 10, S-11883 Stockholm, Sweden.; Älgå, A (通讯作者)，Karolinska Inst, Dept Global Publ Hlth, S-17177 Stockholm, Sweden.
EM andreas.alga@ki.se
RI ; Älgå, Andreas/B-1070-2019; Löfgren, Jenny/J-6694-2019
OI Malmstedt, Jonas/0000-0002-2758-9623; Älgå, Andreas/0000-0001-5245-7668;
   
FU Karolinska Institute; Stockholm County Council [ALF 20160207]; Swedish
   National Board of Health and Welfare [10.1-30118/2019]; Medecins Sans
   Frontieres
FX Open access funding provided by Karolinska Institute. This work was
   supported by the Stockholm County Council (ALF 20160207), the Swedish
   National Board of Health and Welfare (10.1-30118/2019), and Medecins
   Sans Frontieres. No companies were involved in any part of the trial,
   nor did any companies contribute funding. The funders had no role in
   study design, data collection, data analysis, data interpretation, or
   writing of the report.
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NR 18
TC 12
Z9 14
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD FEB 10
PY 2022
VL 17
IS 1
AR 9
DI 10.1186/s13017-022-00415-1
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA YX1DX
UT WOS:000753849900001
PM 35144650
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fung, S
   Ashmawy, H
   Krieglstein, C
   Halama, T
   Schilawa, D
   Fuckert, O
   Hees, A
   Kröpil, F
   Rehders, A
   Lehwald-Tywuschik, NC
   Knoefel, WT
AF Fung, Stephen
   Ashmawy, Hany
   Krieglstein, Christian
   Halama, Thomas
   Schilawa, Dustin
   Fuckert, Oliver
   Hees, Anita
   Kroepil, Feride
   Rehders, Alexander
   Lehwald-Tywuschik, Nadja C.
   Knoefel, Wolfram Trudo
TI Vertical traction device prevents abdominal wall retraction and
   facilitates early primary fascial closure of septic and non-septic open
   abdomen
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Vertical traction; Open abdomen; Retraction prevention; Fasciotens
ID ASSISTED WOUND CLOSURE; COMPARTMENT SYNDROME; SECONDARY PERITONITIS;
   VACUUM; MANAGEMENT; THERAPY; TRAUMA
AB Purpose One of the major challenges in the management of patients with septic and non-septic open abdomen (OA) is to control abdominal wall retraction. The aim of this study was to evaluate the impact of a novel vertical traction device (VTD) on primary fascial closure (PFC) and prevention of fascial retraction. Methods Twenty patients treated with OA were included in this retrospective multicenter study. All patients were initially stabilized with laparostomy and the abdomen temporarily sealed either with a Bogota bag or a negative pressure wound therapy system (NPWT). Results The mean duration of OA and fascia-to-fascia distance (FTF) prior to the VTD application were 3 days and 15 cm, respectively. At relook laparotomy 48 h after VTD implementation, the mean FTF distance significantly decreased to 10 cm (p = 0.0081). In all cases, PFC was achieved after a mean period of 7 days. Twelve patients received the VTD in combination with a NPWT, whereas in eight patients, the device was combined with an alternative temporary abdominal closure system (TAC). Although not statistically significant, the FTF distance remarkably decreased in both groups at relook laparotomy 48 h following the device implementation. The mean periods of PFC for patients with septic and non-septic OA were comparable (7.5 vs. 7 days). During follow-up, two patients developed an incisional hernia. Conclusion Vertical traction device prevents fascial retraction and facilitates early PFC in OA. In combination with NPWT, rapid fascial closure of large abdominal defects can be achieved.
C1 [Fung, Stephen; Ashmawy, Hany; Kroepil, Feride; Rehders, Alexander; Lehwald-Tywuschik, Nadja C.; Knoefel, Wolfram Trudo] Heinrich Heine Univ, Dept Surg A, Moorenstr 5, D-40225 Moorenstrasse, Germany.
   [Fung, Stephen; Ashmawy, Hany; Kroepil, Feride; Rehders, Alexander; Lehwald-Tywuschik, Nadja C.; Knoefel, Wolfram Trudo] Univ Hosp Duesseldorf, Moorenstr 5, D-40225 Moorenstrasse, Germany.
   [Krieglstein, Christian] St Elisabeth Krankenhaus Koln, Dept Surg, Werthmannstr 1, D-50935 Cologne, Germany.
   [Halama, Thomas] St Vinzenz Hosp, Dept Surg, Merheimer Str 221-223, D-50733 Cologne, Germany.
   [Schilawa, Dustin] St Rochus Krankenhaus, Dept Surg, Gluckaufstr 10, D-44575 Castrop Rauxel, Germany.
   [Fuckert, Oliver] Lukas Krankenhaus, Dept Surg, Hindenburgstr 56, D-32257 Bunde, Germany.
   [Hees, Anita] St Marien Krankenhaus, Dept Surg, Kampenstr 51, D-57072 Siegen, Germany.
C3 Heinrich Heine University Dusseldorf; St. Marien Hospital
RP Fung, S (通讯作者)，Heinrich Heine Univ, Dept Surg A, Moorenstr 5, D-40225 Moorenstrasse, Germany.; Fung, S (通讯作者)，Univ Hosp Duesseldorf, Moorenstr 5, D-40225 Moorenstrasse, Germany.
EM stephen.fung@med.uni-duesseldorf.de; knoefel@hhu.de
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 33
TC 14
Z9 18
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD AUG
PY 2022
VL 407
IS 5
BP 2075
EP 2083
DI 10.1007/s00423-021-02424-1
EA FEB 2022
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3Y1TV
UT WOS:000754150600001
PM 35147749
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hauer, T
   Grobert, S
   Gaab, J
   Huschitt, N
   Willy, C
AF Hauer, Thorsten
   Grobert, Steffen
   Gaab, Jasmin
   Huschitt, Niels
   Willy, Christian
TI Blast injuries part 2 Principles of medical treatment
SO UNFALLCHIRURG
LA German
DT Article
DE Extremity injuries; Soft tissue injuries; Infection control; Wound
   closure techniques; Amputation
ID MASSIVE TRANSFUSION PROTOCOLS; DAMAGE CONTROL RESUSCITATION; ACUTE
   THERAPEUTIC MEASURES; PRESSURE WOUND THERAPY; OPEN FRACTURES;
   DEBRIDEMENT; PREVENTION; COVERAGE; CLOSURE; TRAUMA
AB Explosions can cause severe injuries, which affect multiple organ systems and leave extensive soft tissue defects. In unstable patients, damage control surgery initially focuses exclusively on controlling bleeding and contamination with the aim of preserving life and limbs. The excision of all necrotic tissue, extensive wound irrigation with antiseptic solutions and a calculated antibiotic prophylaxis, which is subsequently adapted to the microbiological findings, are the basis for sufficient infection control. As the tissue damage caused by the pressure surge can regenerate over time as well as become secondarily necrotic (developing wounds), several revision operations are often necessary to assess the viability of tissue in the sense of serial debridement. In the case of extensive soft tissue injuries temporary vacuum-assisted closure (VAC) techniques can bridge the time to the earliest possible definitive plastic surgical wound closure; however, this must not delay the closure of the defect.
C1 [Hauer, Thorsten; Grobert, Steffen; Huschitt, Niels] Bundeswehrkrankenhaus Berlin, Klin Allgemein & Viszeralchirurg, Scharnhorststr 13, D-10115 Berlin, Germany.
   [Gaab, Jasmin; Willy, Christian] Bundeswehrkrankenhaus Berlin, Klin Orthopadie & Unfallchirurg, Sept & Rekonstrukt Chirurg, Berlin, Germany.
RP Hauer, T (通讯作者)，Bundeswehrkrankenhaus Berlin, Klin Allgemein & Viszeralchirurg, Scharnhorststr 13, D-10115 Berlin, Germany.
EM ThorstenHauer@Bundeswehr.org
OI Grobert, Steffen/0000-0002-6129-1011
CR American College of Surgeons ATLS, 2008, ATLS ADV TRAUM LIF S
   Back DA, 2013, INT WOUND J, V10, P32, DOI 10.1111/iwj.12183
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NR 40
TC 0
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD MAR
PY 2022
VL 125
IS 3
SI SI
BP 227
EP 242
DI 10.1007/s00113-021-01135-y
EA FEB 2022
PG 16
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA ZI1MG
UT WOS:000754239300001
PM 35147710
DA 2026-07-24
ER
PT J
AU Griffin, LP
   Sifuentes, MM
AF Griffin, Leah P.
   Sifuentes, Mikaela M.
TI Remote Monitoring Saves Costs in Outpatient Negative Pressure Wound
   Therapy
SO AMERICAN JOURNAL OF MANAGED CARE
LA English
DT Article
ID CLOSURE; BURDEN; ULCERS; CARE
AB OBJECTIVES: In the outpatient setting, combining remote therapy monitoring (RTM) with negative pressure wound therapy (NPWT) can support improved adherence to prescribed therapy. A recent study reported that patients receiving NPWT with RTM required fewer therapy days than patients receiving NPWT alone, possibly reducing costs of care. Our objective was to determine whether RTM reduced 90-day costs in patients undergoing NPWT.
   STUDY DESIGN: We conducted a retrospective cohort study of patients receiving NPWT with or without RTM in the postacute setting.
   METHODS: Patients beginning NPWT between March 2018 and May 2019 were included. Payer claims data were collected and analyzed with t test for continuous variables and chi 2 test for categorical variables. Multiple regressions were performed to control for confounding variables.
   RESULTS: Of the 1105 patients included the study, 675 (61%) received RTM and 430 (39%) did not. RTM patients were significantly older (P < .0001), had more ulcers (P = .0004), and had higher Charlson Comorbidity Index (CCI) scores (P < .0001). The unadjusted mean 90-day wound-related cost was not significantly higher for non-RTM patients than for RTM patients (P = .0799). After controlling for differences in age, payer type, CCI score, and wound type, there was a significant reduction in 90-day wound-related costs in the RTM group compared with the non-RTM group ($11,119 vs $14,752; P = .0131). The RTM group had higher NPWT costs ($3757 vs $3289; P = .0035) but lower wound related non-NPWT costs ($7361 vs $11,462; P = .0045).
   CONCLUSIONS: This study demonstrated the value of RTM in supporting NPWT adherence and decreasing the costs of wound care in these patients.
C1 [Griffin, Leah P.; Sifuentes, Mikaela M.] 3M Co, LPG MMS, San Antonio, TX USA.
C3 3M
RP Griffin, LP (通讯作者)，3M Co, 12930 W Interstate 10, San Antonio, TX 78249 USA.
EM lpgriffin@mmm.com
RI Sifuentes, Mikaela/AAJ-1776-2021
OI Sifuentes, Mikaela/0000-0002-7914-4183
CR [Anonymous], 2020, PUBL POLL EM CAR AM
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NR 19
TC 3
Z9 3
U1 0
U2 0
PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC
PI PLAINSBORO
PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA
SN 1088-0224
J9 AM J MANAG CARE
JI Am. J. Manag. Care
PD FEB
PY 2022
VL 28
IS 2
BP 53
EP 58
DI 10.37765/ajmc.2022.88738
PG 6
WC Health Care Sciences & Services; Health Policy & Services; Medicine,
   General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA YX6ZT
UT WOS:000754249400001
PM 35139289
DA 2026-07-24
ER
PT J
AU Sahin, E
   Rizalar, S
   Özker, E
AF Sahin, Ezgi
   Rizalar, Selda
   Ozker, Emre
TI Effectiveness of negative-pressure wound therapy compared to wet-dry
   dressing in pressure injuries
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Negative-pressure wound therapy; Pressure injuries; Vacuum-assisted
   closure; Wound care; Wound measurement
ID VACUUM-ASSISTED CLOSURE; ULCERS; COST; PREVALENCE
AB This study aims to compare the effects of Negative-Pressure Wound Therapy (NPWT) and wet-to-dry dressing on Stages 3 and 4 pressure injuries (PI), This study is a randomized controlled trial. A total of 30 patients with Stages 3 and 4 pressure injuries were included in the study. The patients were divided into two groups: NPWT group and the wet-to-dry dressing group. All patients received 3 rounds of treatment. Data were collected with a Patient Identification Form, Pressure Ulcer Scale for Healing (PUSH) Tool and the findings of the Three-Dimensional Wound Measurement (3DWM) device. We found that granulation tissue formation was more significant in the experimental group (p < .05), and that there was more significant wound shrinkage (p < .05) with a more significant decrease in the PUSH Tool scores (p < .05). The wounds were assessed with the tool and the 3DWM system. Device measurements were found to be correlated with PUSH Tool findings (p < .05). There was a significant correlation between device-measured granulation findings and PUSH Tool score results of the experimental group's third measurements (p < .05). We conclude that NPWT is an effective treatment method for pressure injuries, and 3DWM device is a useable wound assessment tool.
C1 [Sahin, Ezgi] Baskent Univ Istanbul, Hlth Res Applicat Hosp, Istanbul, Turkey.
   [Rizalar, Selda] Hlth Sci Univ, Hamidiye Nursing Fac, Dept Surg Nursing, Selimiye Mah Tibbiye Cad 38, TR-34668 Istanbul, Turkey.
   [Ozker, Emre] Acibadem Mehmet Ali Aydinlar Univ, Hlth Sci Sch, Istanbul, Turkey.
C3 Baskent University; Acibadem University
RP Rizalar, S (通讯作者)，Hlth Sci Univ, Hamidiye Nursing Fac, Dept Surg Nursing, Selimiye Mah Tibbiye Cad 38, TR-34668 Istanbul, Turkey.
EM selda.rizalar@sbu.edu.tr
RI RIZALAR, SELDA/K-4445-2019
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NR 41
TC 19
Z9 21
U1 2
U2 30
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2022
VL 31
IS 1
BP 164
EP 172
DI 10.1016/j.jtv.2021.12.007
EA FEB 2022
PG 9
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA YX8XX
UT WOS:000754380000002
PM 35022147
DA 2026-07-24
ER
PT J
AU Cai, LY
   Mei, YF
   Chen, CH
   Wang, JW
   Wang, XY
   Zheng, WH
AF Cai, Leyi
   Mei, Yifan
   Chen, Chunhui
   Wang, Jinwu
   Wang, Xingyu
   Zheng, Wenhao
TI Comparison of vacuum sealing drainage and conventional drainage for
   postoperative drainage in closed calcaneal fracture: A randomized
   controlled trial
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Vacuum sealing drainage; Calcaneal fracture; Wound complication; Wound
   healing; Clinical study
ID PRESSURE WOUND THERAPY; DISPLACED INTRAARTICULAR FRACTURES; ASSISTED
   CLOSURE; INTERNAL-FIXATION; SURGICAL INCISIONS; OPEN REDUCTION;
   COMPLICATIONS; MANAGEMENT; EXPERIENCE; INJURIES
AB Background: The objective of this study was to compare the outcomes of vacuum sealing drainage (VSD) and conventional drainage after surgery in the treatment of closed calcaneal fracture. We hypothesize that VSD is superior to conventional drainage in reducing volume of drainage, time of wound drying, time of skin fold, time of wound healing, VAS at day 3 postoperatively, wound complications and increasing wound healing grade.
   Methods: 120 patients with closed calcaneal fractures from January 2016 to December 2018 were enrolled in our study. They were divided randomly into VSD group (n = 60) and conventional (n = 60). The volume of drainage, duration of drainage, time of wound drying, time of skin fold, time of wound healing and VAS at day 3 postoperatively were recorded. Furthermore, the wound complications of the two groups were also evaluated. Besides, wound healing grade was used to assess the degree of wound healing. The functional outcome American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot scores and visual analog scale (VAS) pain scores was also evaluated.
   Results: A total of 10 patients were lost to follow-up for various reasons, VSD group remained 55 cases while conventional group remained 53 cases. Our results showed that VSD group exhibited significantly more volume of drainage (P< 0.0001), longer duration of drainage (P< 0.00 01), shorter time of wound drying (P = 0.0086), shorter time of skin fold (P = 0.0158), shorter time of wound healing (P = 0.0240) and lower VAS at day 3 postoperatively (P = 0.0019) compared with conventional group. Moreover, VSD group was demonstrated to have significantly lower wound complications (P = 0.025) and higher rate grade A of wound healing (P = 0.031). However, no significant difference was noted in time of fracture union (P = 0.754), VAS (P = 0.407) and AOFAS score (P = 0.512) at final follow-up between the two groups.
   Conclusions: Our hypothesis was confirmed that VSD was superior in terms of some aspects than conventional drainage. Therefore, VSD is a safe and effective postoperative wound drainage method in the treatment of closed calcaneal fracture. However, more and higher evidence needs to be carried to demonstrate the results. (C) 2021 Elsevier Ltd. All rights reserved.
C1 [Cai, Leyi; Chen, Chunhui; Wang, Jinwu; Wang, Xingyu; Zheng, Wenhao] Wenzhou Med Univ, Dept Orthopaed Surg, Affiliated Hosp 2, 109 Xueyuan Xi Rd, Wenzhou, Peoples R China.
   [Cai, Leyi; Mei, Yifan; Chen, Chunhui; Wang, Jinwu; Wang, Xingyu; Zheng, Wenhao] Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan Xi Rd, Wenzhou, Peoples R China.
   [Mei, Yifan] Wenzhou Med Univ, Dept Emergency, Affiliated Hosp 2, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University
RP Zheng, WH (通讯作者)，Wenzhou Med Univ, Dept Orthopaed Surg, Affiliated Hosp 2, 109 Xueyuan Xi Rd, Wenzhou, Peoples R China.; Zheng, WH (通讯作者)，Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan Xi Rd, Wenzhou, Peoples R China.
EM zhengwenhao@wmu.edu.cn
RI Wang, Xingyu/AFZ-5722-2022; Zheng, Wenhao/KBR-3871-2024
FU National Nature Foundation of China [81701928]; Zhejiang Province
   Medical and Health Technology Project [2017KY480]; Wenzhou Science and
   Technology Bureau Foundation [Y20160040]
FX The authors thank all the staffs in the department of orthopedics of our
   hospital. This study was funded by the National Nature Foundation of
   China (no. 81701928), Zhejiang Province Medical and Health Technology
   Project (2017KY480) and Wenzhou Science and Technology Bureau Foundation
   (no. Y20160040).
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NR 38
TC 21
Z9 28
U1 1
U2 12
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2022
VL 53
IS 2
BP 777
EP 783
DI 10.1016/j.injury.2021.10.018
EA JAN 2022
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA ZA5BK
UT WOS:000756178600023
PM 34756414
DA 2026-07-24
ER
PT J
AU Wenzel, AN
   Apel, PJ
   Gosnell, HL
   Grider, DJ
AF Wenzel, Alyssa N.
   Apel, Peter J.
   Gosnell, Hailey L.
   Grider, Douglas J.
TI Fortuitous Eradication of an Aggressive Basal Cell Carcinoma Via Foreign
   Body Reaction to a Polyurethane Vacuum-Assisted Closure Sponge
SO AMERICAN JOURNAL OF DERMATOPATHOLOGY
LA English
DT Article
DE FBR; basal cell carcinoma; aggressive histopathological features;
   positive surgical margins; polyurethane
ID SPONTANEOUS REGRESSION; INFLAMMATORY GRANULOMAS; GIANT-CELLS
AB The foreign body reaction (FBR) is a well-documented immune reaction. Much of the literature on FBRs has focused on minimizing this immune response to mitigate the impact on medical implants. Here, we present a case that illustrates a serendipitous oncologic outcome from an FBR. A 54-year-old man presented with an aggressive basal cell carcinoma (BCC). At the first resection, he had broadly positive surgical margins. The surgical wound was temporized with a polyurethane wound vacuum assisted closure (VAC) device. He was lost to follow-up having retained a VAC sponge for a total of 12 weeks. A wide re-resection was performed 7 months after the initial resection. Exhaustive examination of the resected specimen was performed. There was an absence of any BCC, replaced by a widespread chronic FBR to polyurethane VAC sponge particles. This suggests that the foreign body immune response was sufficiently intense to eradicate any remaining BCC. This case illustrates the concept of an FBR as a novel method of local immunotherapy.
C1 [Wenzel, Alyssa N.; Apel, Peter J.; Gosnell, Hailey L.; Grider, Douglas J.] Virginia Tech, Carilion Sch Med, 2 Riverside Circle, Roanoke, VA 24016 USA.
   [Apel, Peter J.] Carilion Clin, Dept Orthopaed Surg, Roanoke, VA USA.
   [Grider, Douglas J.] Dominion Pathol Associates, Roanoke, VA USA.
C3 Virginia Polytechnic Institute & State University
RP Wenzel, AN (通讯作者)，Virginia Tech, Carilion Sch Med, 2 Riverside Circle, Roanoke, VA 24016 USA.
EM awenzel5@vt.edu
OI Gosnell, Hailey/0000-0003-4952-2689
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NR 37
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0193-1091
EI 1533-0311
J9 AM J DERMATOPATH
JI Am. J. Dermatopathol.
PD OCT
PY 2021
VL 43
IS 10
BP 740
EP 745
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ZA7IC
UT WOS:000756331900016
PM 33534210
DA 2026-07-24
ER
PT J
AU Arellano, ML
   Serrano, CB
   Guedea, M
   Pérez, JCG
   Ortega, GS
   Guevara-Martinez, J
   Abril, SG
   Puga, CG
   Arroyo, A
   Cid, RC
AF Leon Arellano, Miguel
   Barragan Serrano, Cristina
   Guedea, Manuela
   Garcia Perez, Juan Carlos
   Sanz Ortega, Gonzalo
   Guevara-Martinez, Jenny
   Gomez Abril, Segundo
   Gonzalez Puga, Cristina
   Arroyo, Antonio
   Cantero Cid, Ramon
TI Surgical Wound Complications after Colorectal Surgery with Single-Use
   Negative-Pressure Wound Therapy Versus Surgical Dressing over Closed
   Incisions: A Randomized Controlled Trial
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE colorectal surgery; complications; incision; negative-pressure wound
   therapy; surgical site infection; surgical dressing; wound healing
ID SITE INFECTION REDUCTION
AB BACKGROUND: Global studies indicate that surgical site infections (SSIs) are a major healthcare challenge within hospitals and can have a profound impact on patient quality of life and healthcare costs. Closed-incision negative-pressure therapy (ciNPT) has been reported to provide positive clinical benefits for patients with various incisions, including those following colorectal surgeries.
   METHODS: Investigators performed a prospective, randomized, multicenter trial to evaluate complications of surgical incisions in patients who received a ciNPT dressing versus a conventional surgical dressing (control) over their closed incision following colorectal surgery. The incidence of SSI was determined at 7, 15, and 30 days postsurgery.
   RESULTS: A total of 148 patients participated in the study. Results showed that the SSI rate on day 7 was lower in the ciNPT group versus the control group (10/ 75 [13.3%] vs 17/73 [23.3%]), but this difference was not statistically significant. On day 15, the SSI rate was 12/75 (16.0%) in the ciNPT group versus 21/73 (28.8%) in the control group; however, this difference was only marginally statistically significant (P = .0621). At 1 month, the SSI rate remained lower in the ciNPT group (13/75 [17.3%] vs 21/73 [28.8%], P = .0983) compared with the control group.
   CONCLUSIONS: Future studies with larger population sizes are necessary to determine the impact of ciNPT on patients' incisions after colorectal surgery.
C1 [Leon Arellano, Miguel] Hosp Fdn Jimenez Diaz, Dept Gen & Digest Surg, Madrid, Spain.
   [Barragan Serrano, Cristina] Hosp Fdn Jimenez Diaz, Dept Gen & Digest Surg, Esophagogastr Unit, Madrid, Spain.
   [Guedea, Manuela] Hosp Clin Univ Lozano Blesa, Gen & Digest Surg, Zaragoza, Spain.
   [Garcia Perez, Juan Carlos] Hosp Ramon & Cajal, Gen & Digest Surg, Madrid, Spain.
   [Sanz Ortega, Gonzalo] Hosp Clin San Carlos, Gen & Digest Surg, Madrid, Spain.
   [Guevara-Martinez, Jenny] Hosp Univ La Paz, Madrid, Spain.
   [Gomez Abril, Segundo] Hosp Doctor Pesset, Gen & Digest Surg, Valencia, Spain.
   [Gonzalez Puga, Cristina] Hosp San Cecilio, Gen & Digest Surg, Granada, Spain.
   [Arroyo, Antonio] Hosp Elche, Gen & Digest Surg, Surg, Elche, Spain.
   [Cantero Cid, Ramon] Univ Autonoma Madrid, Med Sci, Madrid, Spain.
C3 Fundacion Jimenez Diaz; Fundacion Jimenez Diaz; Lozano Blesa University
   Clinical Hospital; Hospital Universitario Ramon y Cajal; Hospital
   Clinico San Carlos; Hospital Universitario La Paz; Hospital
   Universitario San Cecilio; Autonomous University of Madrid
RP Arellano, ML (通讯作者)，Hosp Fdn Jimenez Diaz, Dept Gen & Digest Surg, Madrid, Spain.
RI Lopez, Gregorio/PJC-1805-2026; /K-8904-2014; Leon, Miguel/GPP-6800-2022;
   Gomez-Abril, Segundo/AAB-2955-2019; JUAN CARLOS, GARCIA
   PEREZ/U-8344-2017
OI Gomez-Abril, Segundo/0000-0003-3523-1821; JUAN CARLOS, GARCIA
   PEREZ/0000-0002-0326-7128
CR Anderson DJ, 2014, INFECT CONT HOSP EP, V35, P605, DOI 10.1086/676022
   [Anonymous], 2012, Colorectal Cancer-From Prevention to Patient Care
   Bielby, 2011, WOUNDS UK, V7, P47
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   Cima R, 2013, J AM COLL SURGEONS, V216, P23, DOI 10.1016/j.jamcollsurg.2012.09.009
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NR 17
TC 9
Z9 10
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD DEC
PY 2021
VL 34
IS 12
BP 657
EP 661
DI 10.1097/01.ASW.0000756512.87211.13
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA ZB2JJ
UT WOS:000756674400009
PM 34175866
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Yang, H
   Rui, YY
   Chen, H
AF Yang, Hui
   Rui, Yuanyi
   Chen, Hong
TI Management of a Pelvic Abscess and Abdominal Fistula after Palliative
   Total Pelvic Exenteration with Intraoperative Radiotherapy in Recurrent
   Rectal Cancer Without NPWT: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE fistula; intraoperative radiotherapy; negative-pressure wound therapy;
   pelvic abscess; pelvic exenteration; rectal cancer; wound care; wound
   dressing
ID PRESSURE WOUND THERAPY; INFECTION
AB A 59-year-old man with recurrent rectal cancer and type 2 diabetes mellitus underwent palliative total pelvic exenteration and intraoperative radiotherapy. After surgery, he experienced a pelvic abscess and abdominal-perineal fistula. Profuse exudate contaminated the midline abdominal incision through the abdominal-perineal fistula and delayed healing. Because of a residual tumor and the high cost, negative-pressure wound therapy was not performed. After 76 days of local treatment that involved removing necrotic tissue, controlling inflammation with an antimicrobial silver dressing, absorbing and draining exudate with a hypertonic saline dressing, promoting granulation and preventing infection with a silver alginate dressing, and promoting re-epithelialization with recombinant human epidermal growth factor gel, the abdominal wound and abdominal-perineal fistula healed successfully.
C1 [Yang, Hui; Chen, Hong] Sichuan Univ, West China Sch Nursing, Chengdu, Peoples R China.
   [Yang, Hui] Univ Elect Sci & Technol China, Gastrointestinal Surg Ctr, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr,Sch Med, Chengdu, Peoples R China.
   [Rui, Yuanyi] Univ Elect Sci & Technol China, Sch Med, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Chengdu, Peoples R China.
C3 Sichuan University; University of Electronic Science & Technology of
   China; University of Electronic Science & Technology of China
RP Yang, H (通讯作者)，Sichuan Univ, West China Sch Nursing, Chengdu, Peoples R China.; Yang, H (通讯作者)，Univ Elect Sci & Technol China, Gastrointestinal Surg Ctr, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr,Sch Med, Chengdu, Peoples R China.
CR Al-Rikabi AHA, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-020-80072-z
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NR 20
TC 3
Z9 3
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD DEC
PY 2021
VL 34
IS 12
BP 675
EP 679
DI 10.1097/01.ASW.0000797964.31949.b4
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA ZB2JJ
UT WOS:000756674400012
PM 34807899
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Timmermans, FW
   Mokken, SE
   Smit, JM
   Bouman, MB
   van de Grift, TC
   Mullender, MG
   Middelkoop, E
AF Timmermans, Floyd W.
   Mokken, Sterre E.
   Smit, Jan-Maerten
   Bouman, Mark-Bram
   van de Grift, Timotheus C.
   Mullender, Margriet G.
   Middelkoop, Esther
TI The impact of incisional negative pressure wound therapy on scar quality
   and patient-reported outcomes: A within-patient-controlled, randomised
   trial
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE gender reassignment surgery; mastectomy; negative pressure wound
   therapy; patient-reported outcome measure; scar; transgender; wound
   healing
ID SURGICAL WOUNDS; TRANSGENDER; MANAGEMENT; SURGERY; DEVICE; SKIN
AB Literature provides a moderate level of evidence for the beneficial effects of incisional negative pressure wound therapy (iNPWT) on scar quality. The purpose of this study was to establish if iNPWT results in improved scar outcomes in comparison to the standard of care. Therefore, a within-patient randomised controlled, open-label trial was conducted in transgender men undergoing gender-affirming mastectomies. A unilateral side was randomised to receive iNPWT (PICO (TM), Smith&Nephew) without suction drains and contrastingly the standard dressing (Steri-Strips (TM)) with suction drain. Scar quality and questionnaires were bilaterally measured by means of objective assessments and patient-reported outcome measures (PROM) at 1, 3 and 12 months. Objective scar outcomes were scar pliability (Cutometer (R)), colouration (DSM-II) and scar width (3-D imaging). PROM outcomes were related to scars (POSAS and SCAR-Q) and body satisfaction (BODY-Q). From 85 included patients, 80 were included for analyses. No significant difference between treatments was seen in the quantitative outcomes of scar pliability, colour, and width. For qualitative scar outcomes, several significant findings for iNPWT were found for several subscales of the POSAS, SCAR-Q, and BODY-Q. These effects could not be substantiated with linear mixed-model regression, signifying no statically more favourable outcome for either treatment option. In conclusion, this study demonstrated that some PROM outcomes were more favourable for the iNPWT compared to standard treatment. In contrast, the quantitative outcomes showed no beneficial effects of iNPWT on scar outcomes. This suggests that iNPWT is of little benefit as a scar-improving therapy.
C1 [Timmermans, Floyd W.; Mokken, Sterre E.; Smit, Jan-Maerten; Bouman, Mark-Bram; Mullender, Margriet G.; Middelkoop, Esther] Amsterdam UMC, Locat VUmc, Amsterdam Movement Sci, Dept Plast Reconstruct & Hand Surg, Amsterdam, Netherlands.
   [Timmermans, Floyd W.; Mokken, Sterre E.; Smit, Jan-Maerten; Bouman, Mark-Bram; van de Grift, Timotheus C.; Mullender, Margriet G.; Middelkoop, Esther] Amsterdam UMC, Locat VUmc, Ctr Expertise Gender Dysphoria, Amsterdam, Netherlands.
   [Bouman, Mark-Bram; van de Grift, Timotheus C.; Mullender, Margriet G.] Amsterdam UMC, Locat VUmc, Dept Plast Reconstruct & Hand Surg, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [Middelkoop, Esther] Red Cross Hosp, Assoc Dutch Burn Ctr, Beverwijk, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; University of
   Amsterdam
RP Middelkoop, E (通讯作者)，Amsterdam UMC, Locat VUmc, Dept Plast Reconstruct & Hand Surg, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
EM e.middelkoop@amsterdamumc.nl
RI ; Mullender, Margriet/PWH-3332-2026; Middelkoop, Esther/M-3735-2014
OI Mokken, Sterre/0000-0002-8891-969X; Bouman,
   Mark-Bram/0000-0002-4245-783X; Mullender, Margriet/0000-0001-6407-5405;
   Middelkoop, Esther/0000-0001-8843-1080
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   Zwanenburg PR, 2020, ANN SURG, V272, P81, DOI 10.1097/SLA.0000000000003644
NR 37
TC 9
Z9 11
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR
PY 2022
VL 30
IS 2
BP 210
EP 221
DI 10.1111/wrr.13001
EA FEB 2022
PG 12
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA ZL3MW
UT WOS:000758280500001
PM 35146830
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Aref, R
   János, F
   Lóránd, C
   Roland, T
   Rezan, W
AF Aref, Rashed
   Janos, Fulop
   Lorand, Caicut
   Roland, Toth
   Rezan, Watti
TI The role of negative pressure wound therapy in the modern surgery
SO ORVOSI HETILAP
LA English
DT Article
DE modern wound care; wound therapy; wound healing; negative pressure
ID VACUUM-ASSISTED CLOSURE; PERFUSION
AB The introduction of negative pressure wound treatment in its current form into the daily surgical practice started in the 1990s. In addition to the suction of secretions, the aim of the treatment is to improve microcirculation and stimulate the granulation processes in the wound bed. Considering the modern wound management approach, the above method can be used to facilitate the wound healing process of both acute and chronic wounds. In the applica-tion of this method, it is important to emphasize the role of both the properly trained staff and the good patient selection. In our summary, we describe the components of the negative pressure system, the operation of wound care in this form, to present the different types of devices, and to identify the range of patients for whom the treatment can be used successfully. We cover the various technical methods of wound care systems, present the exact practice of treatment, the indications and contraindications, answer important questions that arise during treatment, draw atten-tion to possible complications and discuss how to eliminate them. There are special forms of negative pressure wound care (incisional, endoluminal, and intracavitary negative pressure wound care), which are also presented in detail, as well as application of this treatment in outpatient care. Finally, we draw attention to some special issues that may arise during negative pressure wound treatment, e.g., modification of anticoagulant therapy and treatment of wounds contaminated by multidrug-resistant pathogens.
C1 [Aref, Rashed; Janos, Fulop; Lorand, Caicut; Roland, Toth; Rezan, Watti] Pecsi Tud Egyet, Altalanos Orvostudomanyi Kar, Kihelyezett Szivsebeszeti Tanszek, Zala Megyei Szent Rafael Korhaz,Szivsebeszeti Osz, Zalaegerszeg, Hungary.
C3 University of Pecs
RP Aref, R (通讯作者)，Zrinyi M Ut 1, H-8900 Zalaegerszeg, Hungary.
EM aref.rashed.szv@zmkorhaz.hu
RI /AAO-3555-2020
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NR 34
TC 3
Z9 3
U1 0
U2 5
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0030-6002
EI 1788-6120
J9 ORVOSI HETILAP
JI Orvosi Hetilap
PD FEB
PY 2022
VL 163
IS 7
BP 271
EP 278
DI 10.1556/650.2022.32369
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZF7JA
UT WOS:000759740300003
PM 35152209
OA Green Accepted, hybrid
DA 2026-07-24
ER
PT J
AU Mao, TC
   Zhou, X
   Tian, MN
   Zhang, YM
   Wang, SL
AF Mao, Tong-chun
   Zhou, Xuan
   Tian, Meng-nan
   Zhang, Yi-ming
   Wang, Shao-liang
TI A rare case of male Fournier's gangrene with mixed Actinomyces
   turicensis infection
SO BMC UROLOGY
LA English
DT Article
DE Fournier's gangrene; Actinomyces; Necrotizing fasciitis; Skin grafting;
   Case report
AB Background Fournier's gangrene (FG), a urological emergency with high mortality, is an infectious necrotizing fasciitis of the perineal and genital regions. The majority of FG is caused by polymicrobial organisms involving mixed aerobes and anaerobes but rarely reveals Actinomyces species. Case presentation We report a healthy 67-year-old Asian male who presented with rapidly progressive painful swelling of the scrotum. Clinically diagnosed with FG, the patient underwent an emergency radical debridement, followed by broad-spectrum antibiotics and negative pressure wound therapy. The identification of the causative microorganisms showed Actinomyces turicensis and the antibiotic treatment was adjusted accordingly. After wound bed preparation, we took split-thickness skin grafts to cover the scrotal wound. Active management to minimize faecal contamination was applied throughout the whole course of treatment and repair. The patient was satisfied with the outcome. This was an extremely rare case of A. turicensis as the main causative pathogen of FG. Conclusions FG due to Actinomyces species is rarely reported, but we should still consider this pathogenic microorganism that has long been neglected.
C1 [Mao, Tong-chun; Zhou, Xuan; Tian, Meng-nan; Zhang, Yi-ming; Wang, Shao-liang] Army Med Univ, Xinqiao Hosp, Dept Plast & Cosmet Surg, Chongqing, Peoples R China.
C3 Army Medical University
RP Wang, SL (通讯作者)，Army Med Univ, Xinqiao Hosp, Dept Plast & Cosmet Surg, Chongqing, Peoples R China.
EM xqzxwsl@163.com
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NR 16
TC 9
Z9 11
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2490
J9 BMC UROL
JI BMC Urol.
PD FEB 23
PY 2022
VL 22
IS 1
AR 25
DI 10.1186/s12894-022-00975-z
PG 4
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA ZG4NW
UT WOS:000760237300001
PM 35197026
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rawson, KB
   Neuberger, T
   Smith, T
   Reddy, HRK
   Haussener, TJ
   Sebahar, PR
   Looper, RE
   Isaacson, BM
   Shero, J
   Pasquina, PF
   Williams, DL
AF Rawson, Kaden B.
   Neuberger, Travis
   Smith, Tyler
   Reddy, Hariprasada Reddy Kanna
   Haussener, Travis J.
   Sebahar, Paul R.
   Looper, Ryan E.
   Isaacson, Brad M.
   Shero, John
   Pasquina, Paul F.
   Williams, Dustin L.
TI Antibiofilm potential of a negative pressure wound therapy foam loaded
   with a first-in-class tri-alkyl norspermidine-biaryl antibiotic
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE antimicrobial; drug delivery; release; hydrogel; polyurethane(s); wound
   healing
ID ELUTION KINETICS; COMPLICATIONS
AB Negative-pressure wound therapy (NPWT) is commonly utilized to treat traumatic injuries sustained on the modern battlefield. However, NPWT has failed to decrease the incidence of deep tissue infections experienced by Wounded Warriors, despite attempts to integrate common antimicrobials, like Ag+ nanoparticles, into the wound dressing. The purpose of this study was to incorporate a unique antibiofilm compound (CZ-01179) into the polyurethane matrix of NPWT foam via lyophilized hydrogel scaffolding. Foam samples with 2.5%, 5.0%, and 10.0% w/w CZ-01179 were produced and antibiofilm efficacy was compared to the current standards of care: V.A.C.(R) GRANUFOAM SILVER (TM) and V.A.C.(R) GRANUFOAM (TM). Gravimetric analysis and elution kinetics testing confirmed that this loading technique was both repeatable and controllable. Furthermore, zone of inhibition and antibiofilm efficacy testing showed that foam loaded with CZ-01179 had significantly increased activity against planktonic and biofilm phenotypes of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii compared to the clinical standards. These findings motivate additional ex vivo and in vivo work with NPWT foam loaded with CZ-01179 with the overall objective of reducing NPWT-associated infections that complicate battlefield-related and other wounds.
C1 [Rawson, Kaden B.; Neuberger, Travis; Smith, Tyler; Williams, Dustin L.] Univ Utah, Dept Orthopaed, 20 S 2030 E,Biopolymers Res Bldg,Room 205, Salt Lake City, UT 84112 USA.
   [Reddy, Hariprasada Reddy Kanna; Haussener, Travis J.; Sebahar, Paul R.; Looper, Ryan E.; Williams, Dustin L.] Curza Global, Salt Lake City, UT USA.
   [Sebahar, Paul R.; Looper, Ryan E.] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.
   [Isaacson, Brad M.] Geneva Fdn, Washington, DC USA.
   [Isaacson, Brad M.; Shero, John; Pasquina, Paul F.; Williams, Dustin L.] Uniformed Serv Univ Hlth Sci, Ctr Rehabil Sci Res, Dept Phys Med & Rehabil, Bethesda, MD 20814 USA.
   [Shero, John] Extrem Trauma & Amputat Ctr Excellence, San Antonio, TX USA.
   [Pasquina, Paul F.] Walter Reed Natl Mil Med Ctr, Dept Rehabil, Bethesda, MD USA.
   [Williams, Dustin L.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
   [Williams, Dustin L.] Univ Utah, Dept Pathol, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah; Uniformed Services University of
   the Health Sciences - USA; Walter Reed National Military Medical Center;
   Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Williams, DL (通讯作者)，Univ Utah, Dept Orthopaed, 20 S 2030 E,Biopolymers Res Bldg,Room 205, Salt Lake City, UT 84112 USA.
EM dustin.williams@utah.edu
RI /ABH-4895-2020
OI Rawson, Kaden/0000-0003-2649-6860
FU Center for Rehabilitation Sciences Research Award [HU0001-15-2-0003]
FX Center for Rehabilitation Sciences Research Award, Grant/Award Number:
   HU0001-15-2-0003
CR [Anonymous], 2018, ENV PROT, P22
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NR 23
TC 4
Z9 5
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD AUG
PY 2022
VL 110
IS 8
BP 1780
EP 1788
DI 10.1002/jbm.b.35035
EA FEB 2022
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 2Y0FG
UT WOS:000760963100001
PM 35213779
DA 2026-07-24
ER
PT J
AU Yang, YS
   Liu, MD
   Yang, FF
   Wang, XJ
   Bai, XZ
   Mu, SZ
   Liu, Y
   Hu, DH
AF Yang, Yunshu
   Liu, Mengdong
   Yang, Fangfang
   Wang, Xujie
   Bai, Xiaozhi
   Mu, Shengzhi
   Liu, Yang
   Hu, Dahai
TI Circular RNA expression profiles following negative pressure wound
   therapy in burn wounds with experimental Pseudomonas aeruginosa
   infection
SO BIOENGINEERED
LA English
DT Article
DE Circular RNAs; negative pressure wound therapy; burn wound; Pseudomonas
   aeruginosa; whole-transcriptome sequencing
ID NONCODING RNAS; PERFUSION; MICRORNA
AB Infections of burn wounds, especially those caused by Pseudomonas aeruginosa, could trigger sepsis or septic shock, which is the main cause of death after burn injury. Compared with traditional saline-wet-to-dry dressings, negative pressure wound therapy (NPWT) is more effective for the prevention and treatment of wound infections. However, the mechanism by which NPWT controls infection and accelerates wound healing remains unclear. Accordingly, in this study, the molecular mechanisms underlying the effects of NPWT were explored using a murine model of P. aeruginosa-infected burn wounds. NPWT significantly reduced P. aeruginosa levels in wounds, enhanced blood flow, and promoted wound healing. Additionally, NPWT markedly alleviated wound inflammation and increased the expression of wound healing-related molecules. Recent evidence points to a role of circular RNAs (circRNAs) in wound healing; hence, whole-transcriptome sequencing of wound tissues from NPWT and control groups was performed to evaluate circRNA expression profiles. In total, 12 up-regulated and 25 down-regulated circRNAs were identified between groups. Among these, five significant differentially expressed circRNAs acting as microRNA sponges were identified, and their predicted targets were verified by reverse transcription-quantitative polymerase chain reaction. These results further support the roles of circRNAs in wound healing by NPWT and the prevention of P. aeruginosa infection, providing key molecular targets for further functional analyses.
C1 [Yang, Yunshu; Liu, Mengdong; Wang, Xujie; Bai, Xiaozhi; Liu, Yang; Hu, Dahai] Air Force Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, 029-84775295,127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
   [Yang, Fangfang] Northwest Univ, Sch Life Sci, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Xian, Shaanxi, Peoples R China.
   [Mu, Shengzhi] Shaanxi Prov Peoples Hosp, Dept Burn & Plast Surg, Xian, Shaanxi, Peoples R China.
C3 Air Force Medical University; Northwest University Xi'an; Xi'an Medical
   University
RP Hu, DH (通讯作者)，Air Force Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, 029-84775295,127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.; Liu, Y (通讯作者)，029-84775298,127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
EM 866915@qq.com; hudhai@fmmu.edu.cn
RI Bai, xbai/LMN-4476-2024; Yang, Fangfang/HJH-3693-2023; Yang,
   Yunshu/IXD-9094-2023
FU National Natural Science Foundation of China [81501666]; Natural Science
   Foundation of Shaanxi Province [2021JM-249]; Special Science Research
   Program for National Health and Public Welfare Industry in China
   [201502015]
FX This work was supported by the National Natural Science Foundation of
   China [81501666], Natural Science Foundation of Shaanxi Province
   [2018JQ8049], Natural Science Foundation of Shaanxi Province
   [2021JM-249] and Special Science Research Program for National Health
   and Public Welfare Industry in China [201502015].
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NR 35
TC 7
Z9 7
U1 1
U2 16
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2165-5979
EI 2165-5987
J9 BIOENGINEERED
JI Bioengineered
PD FEB 1
PY 2022
VL 13
IS 2
BP 4122
EP 4136
DI 10.1080/21655979.2021.2006965
PG 15
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA ZI6TB
UT WOS:000761750400001
PM 34898366
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, Y
   Zhang, ZB
   Liu, JS
   Wu, ZM
   Sun, XC
   Zhao, YT
   Zhang, XZ
AF Li, Yong
   Zhang, Zhi-bo
   Liu, Ji-song
   Wu, Zhu-min
   Sun, Xin-cheng
   Zhao, Yu-tin
   Zhang, Xiang-zhou
TI Analysis of the therapeutic effect of artificial leather embedding
   combined with fascial sleeve flap transplantation on chronic wounds of
   lower limbs with bone and plate exposure
SO BMC SURGERY
LA English
DT Article
DE Bone exposure; Chronic wound; Plate exposure; Artificial dermis; Flap
ID SKIN; FRACTURES; MUSCLE
AB Background After severe trauma of lower limbs, bone, tendon or plate graft exposure is common. The traditional repair method is to use a variety of skin flap transplantation to cover the exposed part, but the wound often can not heal after operation, or the wound is cracked, ulcer, sinus, bone and steel plate are exposed again after wound healing. The reason for this result is that when the flap is covered, the space around the bone plate is not well closed, forming a dead cavity, blood and exudate accumulation, hematoma formation or infection, and finally the wound ruptures again. In addition, due to the swelling and contracture of the flap after operation, the suture tension between the flap and the receiving area becomes larger, the skin becomes thinner and broken, and then the wound is formed. In order to solve the above problems, we carried out the study of artificial true skin embedding combined with fascial sleeve flap transplantation in the treatment of chronic bone plate exposed wounds of lower limbs. Methods In this paper, 11 cases of chronic wounds with bone exposure and skin necrosis after steel plate implantation were selected. First stage is the wound bed preparation including primary wound expansion, removal of necrotic tissue and incision of sinus wall, removal of deep necrotic bone and fibrotic scarred skin on the outer wall of steel plate to normal tissue on the outer edge of the wound, removal of precipitated peptone and purulent fur in the hole, periphery and bone space of the steel plate, and removal of tendon tissue with basal necrosis and disintegration of the wound. After vacuum sealing drainage (VSD) 1-2 weeks, the peritraumatic basal granulation tissue grew well and there was no necrotic tissue in the wound. In the second stage, the exposed bone was covered with artificial dermis, the steel plate hole or the periphery and the basal space were filled, and the exposed steel plate was completely embedded, and then the fascia sleeve flap was transplanted to cover the wound. The sural neurovascular flap was performed in nine cases and the lateral superior malleolar artery perforator flap in two case. Results The flap survived well in all 11 cases. During the follow-up of 6 months to the removal of the plate, there was no case of rupture, exposure and sinus formation. Conclusions Artificial dermal covering combined with fascial sleeve flap transplantation can effectively avoid wound dehiscence or sinus formation caused by foreign body retention, infection and flap contracture. It has good effect in repairing chronic wounds with bone plate exposure after severe trauma of lower limbs.
C1 [Li, Yong; Zhang, Zhi-bo; Liu, Ji-song; Wu, Zhu-min; Sun, Xin-cheng; Zhao, Yu-tin; Zhang, Xiang-zhou] Third Hosp Bengbu, Dept Burn & Plast Surg, Bengbu 233000, Peoples R China.
RP Liu, JS (通讯作者)，Third Hosp Bengbu, Dept Burn & Plast Surg, Bengbu 233000, Peoples R China.
EM 406084878@qq.com
FU Bengbu science and Technology Bureau [20200324]
FX This study was supported by Bengbu science and Technology Bureau
   (20200324).
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NR 27
TC 6
Z9 10
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD FEB 26
PY 2022
VL 22
IS 1
AR 69
DI 10.1186/s12893-022-01521-2
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ZI9RG
UT WOS:000761948600004
PM 35219291
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Popivanov, G
   Cirocchi, R
   Penchev, D
   Kjossev, K
   Konaktchieva, M
   Mutafchiyski, V
AF Popivanov, Georgi
   Cirocchi, Roberto
   Penchev, Dimitar
   Kjossev, Kirien
   Konaktchieva, Marina
   Mutafchiyski, Ventsislav
TI Successful Negative Pressure Therapy of Enteroatmospheric Fistula after
   Right Colectomy for Complicated Crohn's Disease -A Proposal for a
   Three-Drain Wound-Separation Technique
SO MEDICINA-LITHUANIA
LA English
DT Article
DE enteroatmospheric fistula; frozen abdomen; modified technique; staged
   wound closure
ID OPEN ABDOMEN; NUTRITION; CLOSURE; TRAUMA
AB Enteroatmospheric fistulas (EAFs) are still the worst complication of the open abdomen. They lead to a significantly prolonged intensive care unit and hospital stay and to high mortality. Despite the various techniques described in the literature EAFs remain "a nightmare" for the patient, the surgeon, and the hospital. Here we describe a case of right colectomy for obstructing Crohn's disease in a 26-year-old. On the 19th postoperative day, he developed a superficial EAF. Due to the frozen abdomen, neither resection of the anastomosis, nor implementation of the known techniques for treatment of EAFs were possible. This prompted us to modify the Pepe technique. The EAF was isolated from the upper and lower parts of the wound through deep-skin and subcutaneous sutures and the application of two small pieces of non-adherent plastic foil. The lower holes of a single drain, put through a piece of black foam, were placed over the fistula. The upper holes, which were enveloped with the foam, remained in contact with the wound. The drain was connected to a negative pressure of 125 mmHg. NPWT (negative pressure wound therapy) was also applied by two separate sponges and drains in the upper and lower part. The mainstay of EAF treatment is the isolation of the EAF from the abdominal cavity and subcutaneous tissue, supported by control of the sepsis and adequate nutrition. The proposed technique is applicable in cases with a single, superficial EAF on the background of the frozen abdomen with minimal lateral fascial retraction. As of today, due to the rarity of the condition and lack of randomized trials, EAFs still represents a unique challenge often requiring improvisation.
C1 [Popivanov, Georgi; Penchev, Dimitar; Kjossev, Kirien; Mutafchiyski, Ventsislav] Mil Med Acad, Dept Surg, Sv G Sofiiski Str 3, Sofia 1606, Bulgaria.
   [Cirocchi, Roberto] Univ Perugia, Dept Surg Sci, I-06123 Perugia, Italy.
   [Konaktchieva, Marina] Mil Med Acad, Dept Gastroenterol Hepatol & Transplantol, Sv G Sofiiski Str 3, Sofia 1606, Bulgaria.
C3 Military Medical Academy Sofia; University of Perugia; Military Medical
   Academy Sofia
RP Popivanov, G (通讯作者)，Mil Med Acad, Dept Surg, Sv G Sofiiski Str 3, Sofia 1606, Bulgaria.
EM gerasimpopivanov@rocketmail.com; roberto.cirocchi@unipg.it;
   d.k.penchev@gmail.com; kirienkt@gmail.com;
   marina.konaktchieva@yahoo.com; ventzimm@gmail.com
RI Kjossev, Kirien/KQV-3036-2024; Cirocchi, Roberto/I-1197-2014; Popivanov,
   Georgi/IVH-4670-2023
OI Cirocchi, Roberto/0000-0002-2457-0636; Popivanov,
   Georgi/0000-0001-9618-3187
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NR 14
TC 2
Z9 4
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD FEB
PY 2022
VL 58
IS 2
AR 199
DI 10.3390/medicina58020199
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZK0IR
UT WOS:000762681700001
PM 35208523
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Seng, L
   Drovandi, A
   Fernando, ME
   Golledge, J
AF Seng, Leonard
   Drovandi, Aaron
   Fernando, Malindu E.
   Golledge, Jonathan
TI Opinions about the most appropriate surgical management of
   diabetes-related foot infection: a cross-sectional survey
SO JOURNAL OF FOOT AND ANKLE RESEARCH
LA English
DT Article
DE Clinical practice; Diabetic foot disease; Orthopaedic surgery; Survey;
   Vascular surgery
ID OSTEOMYELITIS
AB Background There is a lack of high quality evidence to guide the optimal management of diabetes-related foot infection, particularly in cases of severe diabetes-related foot infection and diabetes-related foot osteomyelitis. This study examined the opinions of surgeons about the preferred management of severe diabetes-related foot infection. Methods Vascular and orthopaedic surgeons in Australia and New Zealand were invited to complete an online survey via email. The survey included multi-choice and open-ended questions on clinical management of diabetes-related foot infection. Responses of vascular surgeons and orthopaedic surgeons were compared using non-parametric statistical tests. Open-text responses were examined using inductive content analysis. Results 29 vascular and 20 orthopaedic surgeons completed the survey. One-third (28.6%) used best-practice guidelines to assist in decisions about foot infection management. Areas for guideline improvement identified included more specific advice regarding the indications for available treatments, more recommendations about non-surgical patient management and advice on how management can be varied in regions with limited health service resource. The probe-to-bone test and magnetic resonance imaging were the preferred methods of diagnosing osteomyelitis. Approximately half (51.2%) of respondents indicated piperacillin combined with tazobactam as the preferred antibiotic choice for empirical treatment of severe diabetes-related foot infection. Negative pressure wound therapy was the most common way of managing a wound following debridement. All vascular surgeons (100%) made revascularisation decisions based on the severity of ischemia while most orthopaedic surgeons (66.7%) were likely to refer to vascular surgeons to make revascularisation decisions. Vascular surgeons preferred using wound swabs while orthopaedic surgeons favoured tissue or bone biopsies to determine the choice of antibiotic. Respondents perceived a moderate variation in management decisions between specialists and supported the need for randomised controlled trials to test different management pathways. Conclusions Most vascular and orthopaedic surgeons do not use best-practice guidelines to assist in decisions about management of diabetes-related foot infection. Vascular and orthopaedic surgeons appear to have different preferences for wound sampling to determine choice of antibiotic. There is a need for higher quality evidence to clarify best practice for managing diabetes-related foot infection.
C1 [Seng, Leonard; Drovandi, Aaron; Fernando, Malindu E.; Golledge, Jonathan] James Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld 4811, Australia.
   [Fernando, Malindu E.] Univ Newcastle, Fac Hlth & Med, Sch Hlth Sci, Newcastle, NSW, Australia.
   [Fernando, Malindu E.; Golledge, Jonathan] James Cook Univ, Australian Inst Trop Hlth & Med, Ulcer & Wound Healing Consortium UHEAL, Townsville, Qld, Australia.
   [Golledge, Jonathan] Townsville Univ Hosp, Dept Vasc & Endovasc Surg, Townsville, Qld, Australia.
C3 James Cook University; University of Newcastle; James Cook University
RP Golledge, J (通讯作者)，James Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld 4811, Australia.; Golledge, J (通讯作者)，James Cook Univ, Australian Inst Trop Hlth & Med, Ulcer & Wound Healing Consortium UHEAL, Townsville, Qld, Australia.; Golledge, J (通讯作者)，Townsville Univ Hosp, Dept Vasc & Endovasc Surg, Townsville, Qld, Australia.
EM jonathan.golledge@jcu.edu.au
RI ; golledge, jonathan/I-2371-2013; Drovandi, Aaron/KXQ-9788-2024
OI Drovandi, Aaron/0000-0002-8682-1218; golledge,
   jonathan/0000-0002-5779-8848; 
FU James Cook University; National Health and Medical Research Council
   [1117061]; Queensland Government, Australia
FX The study was funded by a grant from James Cook University. JG holds a
   Practitioner Fellowship from the National Health and Medical Research
   Council (1117061) and a Senior Clinical Research Fellowship from the
   Queensland Government, Australia.
CR Commons RJ, 2018, J FOOT ANKLE RES, V11, DOI 10.1186/s13047-018-0256-3
   Diabetes Feet Australia, DEV NEW AUSTR GUID D
   Diabetic Foot Australia, 2021, AUSTR INT GUIDELINES
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NR 19
TC 3
Z9 4
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1757-1146
J9 J FOOT ANKLE RES
JI J. Foot Ankle Res.
PD MAR 2
PY 2022
VL 15
IS 1
AR 18
DI 10.1186/s13047-022-00523-w
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA ZK1BL
UT WOS:000762730900001
PM 35232476
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Wichmann, D
   Fusco, S
   Werner, CR
   Voesch, S
   Duckworth-Mothes, B
   Schweizer, U
   Stueker, D
   Koenigsrainer, A
   Thiel, K
   Quante, M
AF Wichmann, Doerte
   Fusco, Stefano
   Werner, Christoph R.
   Voesch, Sabrina
   Duckworth-Mothes, Benedikt
   Schweizer, Ulrich
   Stueker, Dietmar
   Koenigsrainer, Alfred
   Thiel, Karolin
   Quante, Markus
TI Endoscopic Management for Post-Surgical Complications after Resection of
   Esophageal Cancer
SO CANCERS
LA English
DT Review
DE esophageal cancer; endoscopic complication management; postsurgical
   complication
ID VACUUM-ASSISTED CLOSURE; MINIMALLY INVASIVE ESOPHAGECTOMY; MANAGING
   ANASTOMOTIC LEAKAGE; REFRACTORY GASTROPARESIS; RETROSPECTIVE ANALYSIS;
   SUBMUCOSAL DISSECTION; BOTULINUM-TOXIN; RESCUE THERAPY; RISK-FACTORS;
   STENT
AB Simple Summary Flexible endoscopy has an important part in the diagnosis and treatment of postoperative complications after oncologically intended esophagectomy. Endoscopy offers the possibility of effective therapy with minimal invasiveness at the same time, and the use of endoscopic therapy procedures can avoid re-operations. In this review we present the advantages of endoscopic treatment opportunities during the last 20 years regarding patients' treatment after esophageal cancer resection. According to prevalence and clinical relevance, four relevant postoperative complications were identified and their endoscopic treatment procedures discussed. All endoscopic therapy procedures for anastomotic bleeding, anastomotic insufficiencies, anastomotic stenosis and postoperative delayed gastric emptying are presented, including innovative developments. Background: Esophageal cancer (EC) is the sixth-leading cause of cancer-related deaths in the world. Esophagectomy is the most effective treatment for patients without invasion of adjacent organs or distant metastasis. Complications and relevant problems may occur in the early post-operative course or in a delayed fashion. Here, innovative endoscopic techniques for the treatment of postsurgical problems were developed during the past 20 years. Methods: Endoscopic treatment strategies for the following postoperative complications are presented: anastomotic bleeding, anastomotic insufficiency, delayed gastric passage and anastomotic stenosis. Based on a literature review covering the last two decades, therapeutic procedures are presented and analyzed. Results: Addressing the four complications mentioned, clipping, stenting, injection therapy, dilatation, and negative pressure therapy are successfully utilized as endoscopic treatment techniques today. Conclusion: Endoscopic treatment plays a major role in both early-postoperative and long-term aftercare. During the past 20 years, essential therapeutic measures have been established. A continuous development of these techniques in the field of endoscopy can be expected.
C1 [Wichmann, Doerte; Duckworth-Mothes, Benedikt; Schweizer, Ulrich; Stueker, Dietmar; Koenigsrainer, Alfred; Thiel, Karolin; Quante, Markus] Univ Hosp Tubingen, Dept Gen Visceral & Transplantat Surg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
   [Fusco, Stefano; Werner, Christoph R.; Voesch, Sabrina] Univ Hosp Tubingen, Dept Gastroenterol Gastrointestinal Oncol Hepatol, Otfried Muller Str 10, D-72076 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital
RP Wichmann, D (通讯作者)，Univ Hosp Tubingen, Dept Gen Visceral & Transplantat Surg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
EM doerte.wichmann@med.uni-tuebingen.de;
   stefano.fusco@med.uni-tuebingen.de;
   christoph.werner@med.uni-tuebingen.de;
   sabrina.voesch@med.uni-tuebingen.de;
   benedikt.mothes@med.uni-tuebingen.de;
   ulrich.schweizer@med.uni-tuebingen.de;
   dietmar.stueker@med.uni-tuebingen.de;
   karolin.thiel@med.uni-tuebingen.de; karolin.thiel@med.uni-tuebingen.de;
   markus.quante@med.uni-tuebingen.de
RI Fusco, Stefano/JYQ-3117-2024
OI Fusco, Stefano/0000-0001-6093-4567; Quante, Markus/0000-0002-2206-107X;
   , Doerte/0000-0002-8832-5031; Duckworth-Mothes,
   Benedikt/0000-0002-2352-2325
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NR 116
TC 7
Z9 10
U1 2
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD FEB
PY 2022
VL 14
IS 4
AR 980
DI 10.3390/cancers14040980
PG 15
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA ZL5TB
UT WOS:000763738400001
PM 35205730
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ahmad, I
   Khanna, R
   Prakash, P
   Khanna, S
   Meena, RN
AF Ahmad, Irshad
   Khanna, Rahul
   Prakash, Pradyot
   Khanna, Siddharth
   Meena, Ram Niwas
TI Sacral Pressure Ulcer Management by Negative Pressure Dressing: a
   Randomized Open Label Study
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Sacral pressure ulcer; Negative pressure wound therapy; Vacuum assisted
   closure
ID WOUND THERAPY
AB The treatment of sacral pressure sores is associated with a high rate of failure and recurrence. If inadequately treated, they severely compromise the quality of life and may herald a terminal event. The present study was undertaken to compare the efficacy of negative pressure wound therapy (NPWT) with conventional dressing treatment for sacral pressure sores. Over a 4-year period, 38 patients of grade III and IV sacral pressure sores were treated by either NPWT (22 patients) or conventional dressing (16 patients) method. Prior to application of NPWT, the wound was debrided and complete hemostasis achieved. The NPWT device was set to deliver a negative pressure of 125 mmHg with 7-min cycle (5 min on pump followed by 2 min off). The dressing was changed after 5 to 7 days. At the end of 3 months of treatment, 4 patients had died in each group. Of the 18 patients alive in NPWT group, 6 patients (33%) achieved complete healing and 9 (50%) had wound size reduction by more than 50%. The corresponding figures in the conventional dressing group were 1 (8%) and 4 patients (33%), respectively. NPWT was found to achieve superior clearance of slough, better generation of granulation tissue, and obliteration of ulcer crater compared to conventional dressing. The negative pressure led to faster reduction of bacterial load promoted angiogenesis and obtained a better rate of wound healing. Moreover, it resulted in a much cleaner and hygienic wound environment, reduced the nursing time in change of dressing, and significantly decreased patient discomfort.
C1 [Ahmad, Irshad; Khanna, Rahul; Khanna, Siddharth; Meena, Ram Niwas] Banaras Hindu Univ, Inst Med Sci, Dept Surg, Varanasi 221005, Uttar Pradesh, India.
   [Prakash, Pradyot] Banaras Hindu Univ, Inst Med Sci, Dept Microbiol, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Banaras Hindu University (BHU)
RP Khanna, R (通讯作者)，Banaras Hindu Univ, Inst Med Sci, Dept Surg, Varanasi 221005, Uttar Pradesh, India.
EM dr_rahul_khanna@rediffmail.com
RI ; Prakash, Pradyot/O-3713-2016
OI Khanna, Rahul/0000-0002-5691-7403; Prakash, Pradyot/0000-0003-3622-4295
CR Bao Philip, 2009, J Surg Res, V153, P347, DOI 10.1016/j.jss.2008.04.023
   Bhattacharya S, 2015, INDIAN J PLAST SURG, V48, P4, DOI 10.4103/0970-0358.155260
   Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
   de Angelis B, 2013, INT WOUND J, V10, P336, DOI 10.1111/j.1742-481X.2012.00982.x
   Desneves KJ, 2005, CLIN NUTR, V24, P979, DOI 10.1016/j.clnu.2005.06.011
   Gabriel A, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00628.x
   Gargano F, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001234
   Manpinath BD., 2019, NEW INDIA J SURG, V10, P77
   National pressure Ulcer Advisory Panel and European Pressure Ulcer Advisory Panel, 2009, PREVENTION TREATMENT
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   Toy LW, 2011, J AM ACAD NURSE PRAC, V23, P183, DOI 10.1111/j.1745-7599.2011.00600.x
   Webb LX, 2008, J ORTHOP TRAUMA, V22, pS135, DOI 10.1097/BOT.0b013e31818956ce
NR 13
TC 0
Z9 0
U1 1
U2 15
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD FEB
PY 2023
VL 85
IS 1
BP 65
EP 70
DI 10.1007/s12262-022-03347-x
EA MAR 2022
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9D9DL
UT WOS:000764911300001
DA 2026-07-24
ER
PT J
AU Crumley, C
AF Crumley, Carolyn
TI Abdominal Negative Pressure Wound Therapy Devices for Management of the
   Open Abdomen A Technologic Analysis
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Abdominal; Negative pressure wound therapy; Open abdomen; Safety;
   Technology; Vacuum-assisted closure; Wound vac
ID CLOSURE TECHNIQUES; SYSTEMS; COST
AB PURPOSE: The purpose of this technologic analysis was to analyze technologic features of abdominal negative pressure wound therapy (NPWT). APPROACH: Published literature regarding abdominal negative pressure wound therapy (aNPWT) devices was reviewed. A summary of management approaches for the open abdomen provides a foundation for understanding the benefits of aNPWT. Safety information regarding aNPWT was derived from the Manufacturer and User Facility Device Experience (MAUDE) Database. CONCLUSIONS: The open abdomen approach with temporary abdominal closure may be employed for patients with a variety of conditions. Specialized abdominal NPWT devices, either singly or in combination with other approaches, may contribute to improved outcomes in this high-risk patient population. Manufacturer recommendations and clinical guidelines should be followed to minimize patient risk.
C1 [Crumley, Carolyn] St Lukes East Hosp, Lees Summit, MO USA.
   [Crumley, Carolyn] Univ Missouri, Sinclair Sch Nursing, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia
RP Crumley, C (通讯作者)，3712 NE Beechwood Dr, Lees Summit, MO 64064 USA.
EM carolyn_crumley@sbcglobal.net
CR Aguilar-Frasco J, 2019, INT J SURG CASE REP, V61, P174, DOI 10.1016/j.ijscr.2019.07.047
   Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
   Bartholomew R, 2021, CRIT CARE MED, V49, P466
   Betancourt AS, 2020, ANN MED SURG, V56, P11, DOI 10.1016/j.amsu.2020.06.007
   Bruhin A, 2014, INT J SURG, V12, P1105, DOI 10.1016/j.ijsu.2014.08.396
   Carlson GL, 2013, ANN SURG, V257, P1154, DOI 10.1097/SLA.0b013e31828b8bc8
   Cirocchi R, 2016, J TRAUMA ACUTE CARE, V81, P575, DOI 10.1097/TA.0000000000001126
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
   Cristaudo A, 2017, AM SURGEON, V83, P191
   Frazee RC, 2013, J AM COLL SURGEONS, V216, P730, DOI 10.1016/j.jamcollsurg.2012.12.035
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   Long KL, 2014, AM SURGEON, V80, P567
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   Rao M, 2007, COLORECTAL DIS, V9, P266, DOI 10.1111/j.1463-1318.2006.01154.x
   Tolonen M, 2017, J TRAUMA ACUTE CARE, V82, P1100, DOI 10.1097/TA.0000000000001452
NR 18
TC 0
Z9 1
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAR-APR
PY 2022
VL 49
IS 2
BP 124
EP 127
DI 10.1097/WON.0000000000000862
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA ZO1LM
UT WOS:000765489000007
PM 35255062
DA 2026-07-24
ER
PT J
AU Ruiz-Tovar, J
   Boermeester, MA
   Bordeianou, L
   Chang, GJ
   Gorgun, E
   Justinger, C
   Lawson, EH
   Leaper, DJ
   Mahmoud, NN
   Mantyh, C
   McGee, MF
   Nfonsam, V
   Rubio-Perez, I
   Wick, EC
   Hedrick, TL
AF Ruiz-Tovar, Jaime
   Boermeester, Marja A.
   Bordeianou, Liliana
   Chang, George J.
   Gorgun, Emre
   Justinger, Christoph
   Lawson, Elise H.
   Leaper, David J.
   Mahmoud, Najjia N.
   Mantyh, Christopher
   McGee, Michael F.
   Nfonsam, Valentine
   Rubio-Perez, Ines
   Wick, Elizabeth C.
   Hedrick, Traci L.
CA Colorectal Delphi Facilitating Grp
TI Delphi Consensus on Intraoperative Technical/Surgical Aspects to Prevent
   Surgical Site Infection after Colorectal Surgery
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article; Proceedings Paper
CT 107th Annual Clinical Congress and Scientific Forum of the
   American-College-of-Surgeons (ACS) / Owen H. Wangensteen Scientific
   Forum
CY OCT 23-28, 2021
CL ELECTR NETWORK
SP Amer Coll Surg
ID RANDOMIZED CONTROLLED-TRIAL; TRICLOSAN-COATED SUTURES; WOUND EDGE
   PROTECTOR; SKIN CLOSURE; ABDOMINAL-SURGERY; SUBCUTICULAR SUTURES;
   GASTROINTESTINAL SURGERY; CLINICAL-TRIAL; OPEN-LABEL; METAANALYSIS
AB BACKGROUND: Previous studies have focused on the development and evaluation of care bundles to reduce the risk of surgical site infection (SSI) throughout the perioperative period. A focused examination of the technical/surgical aspects of SSI reduction during CRS has not been conducted. This study aimed to develop an expert consensus on intraoperative technical/surgical aspects of SSI prevention by the surgical team during colorectal surgery (CRS).
   STUDY DESIGN: In a modified Delphi process, a panel of 15 colorectal surgeons developed a consensus on intraoperative technical/surgical aspects of SSI prevention undertaken by surgical personnel during CRS using information from a targeted literature review and expert opinion. Consensus was developed with up to three rounds per topic, with a prespecified threshold of >= 70% agreement.
   RESULTS: In 3 Delphi rounds, the 15 panelists achieved consensus on 16 evidence-based statements. The consensus panel supported the use of wound protectors/retractors, sterile incision closure tray, preclosure glove change, and antimicrobial sutures in reducing SSI along with wound irrigation with aqueous iodine and closed-incision negative pressure wound therapy in high-risk, contaminated wounds.
   CONCLUSIONS: Using a modified Delphi method, consensus has been achieved on a tailored set of recommendations on technical/surgical aspects that should be considered by surgical personnel during CRS to reduce the risk of SSI, particularly in areas where the evidence base is controversial or lacking. This document forms the basis for ongoing evidence for the topics discussed in this article or new topics based on newly emerging technologies in CRS. (C) 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Surgeons.
C1 [Ruiz-Tovar, Jaime] Univ Rey Juan Carlos, Dept Surg, Madrid, Spain.
   [Boermeester, Marja A.] Free Univ Amsterdam Hosp, Dept Surg, Amsterdam, Netherlands.
   [Bordeianou, Liliana] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA.
   [Chang, George J.] Univ Texas MD Anderson Canc Ctr, Dept Colon & Rectal Surg, Houston, TX 77030 USA.
   [Gorgun, Emre] Cleveland Clin, Digest Dis & Surg Inst, Dept Colorectal Surg, Cleveland, OH USA.
   [Justinger, Christoph] Klinikum Karlsruhe, Dept Gen & Visceral Surg, Karlsruhe, Germany.
   [Justinger, Christoph] Albert Ludwigs Univ Freiburg, Freiburg, Germany.
   [Lawson, Elise H.] Univ Wisconsin, Dept Surg, Div Colorectal, Madison, WI USA.
   [Leaper, David J.] Univ Newcastle, Surg, Newcastle Upon Tyne, Tyne & Wear, England.
   [Mahmoud, Najjia N.] Univ Penn, Div Colon & Rectal Surg, Philadelphia, PA 19104 USA.
   [Mantyh, Christopher] Duke Univ, Med Ctr, Dept Surg, Durham, NC USA.
   [McGee, Michael F.] Northwestern Univ, Dept Surg, Feinberg Sch Med, Chicago, IL USA.
   [Nfonsam, Valentine] Univ Arizona, Dept Surg, Tucson, AZ USA.
   [Rubio-Perez, Ines] La Paz Univ Hosp, Dept Gen Surg, Colorectal Surg Unit, Madrid, Spain.
   [Wick, Elizabeth C.] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA.
   [Hedrick, Traci L.] Univ Virginia Hlth Syst, Dept Surg, 1215 Lee St, Charlottesville, VA 22903 USA.
C3 Universidad Rey Juan Carlos; Vrije Universiteit Amsterdam; Amsterdam
   University Medical Center; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; University of Texas
   System; UTMD Anderson Cancer Center; Cleveland Clinic Foundation;
   Municipal Hospital Karlsruhe; University of Freiburg; University of
   Wisconsin System; University of Wisconsin Madison; Newcastle University
   - UK; University of Pennsylvania; Duke University; Northwestern
   University; Feinberg School of Medicine; University of Arizona; Hospital
   Universitario La Paz; University of California System; University of
   California San Francisco; University of Virginia; University of Virginia
   (UVA) Health System
RP Hedrick, TL (通讯作者)，Univ Virginia Hlth Syst, Dept Surg, 1215 Lee St, Charlottesville, VA 22903 USA.
EM th8q@hscmail.mcc.virginia.edu
RI mantyh, christopher/AAJ-9140-2021; Lawson, Elise/PYZ-3977-2026; Hedrick,
   Traci/AAG-9788-2019
OI Rubio-Perez, Ines/0000-0002-3960-6865; McGee,
   Michael/0000-0002-9498-4252
FU Johnson Johnson; Ethicon, Inc.
FX This study was supported by funding from Johnson & Johnson and Ethicon,
   Inc.
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NR 66
TC 28
Z9 31
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD JAN
PY 2022
VL 234
IS 1
BP 1
EP 11
DI 10.1097/XCS.0000000000000022
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA ZO7MS
UT WOS:000765911900001
PM 35213454
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Kurazumi, H
   Suzuki, R
   Nawata, R
   Yokoyama, T
   Tsubone, S
   Matsuno, Y
   Mikamo, A
   Hamano, K
AF Kurazumi, Hiroshi
   Suzuki, Ryo
   Nawata, Ryosuke
   Yokoyama, Toshiki
   Tsubone, Sarii
   Matsuno, Yutaro
   Mikamo, Akihito
   Hamano, Kimikazu
TI Feasibility of open chest management with modified negative pressure
   wound therapy immediately after cardiac surgery
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Delayed sternal closure; Open chest management; Negative wound pressure
   therapy
ID DELAYED STERNAL CLOSURE
AB Prolonged surgery, cardiopulmonary bypass or cardiac arrest can lead to myocardial, mediastinal and pulmonary oedema.
   OBJECTIVES To evaluate the feasibility of open chest management with our modified negative pressure wound therapy immediately after cardiac surgery as a therapy for atypical tamponade. METHODS Open chest with modified negative pressure wound therapy was performed immediately after cardiac surgery. The surface of the heart and the vessels were covered with non-adherent siliconized gauze. The sternal halves were stented using edge-cut disposable syringes to maintain a larger mediastinal cavity. Approximately 45 mm of distance was kept between the sternal edges. A trimmed sterile polyvinyl foam sponge was inserted into the mediastinum, the entire wound was sealed and negative pressure (-50 to -75 mmHg) was applied using a suction generator. Delayed chest closure was performed in a standard manner once the haemodynamic status was stabilizsed. RESULTS The mortality rate was 3/15 (20%) patients. Deep sternal wound infection occurred in 1/15 (6.7%) patients. Five patients were extubated during the open chest management. Sternal closure was delayed for median of 3 days after the initial surgery. There was no incidence of bleeding complications or need for additional haemostatic procedures. CONCLUSIONS Negative pressure wound therapy performed immediately after cardiac surgery was feasible in our small number of patients. Clinical registration number Study ID: 2020-149.
C1 [Kurazumi, Hiroshi; Suzuki, Ryo; Nawata, Ryosuke; Yokoyama, Toshiki; Tsubone, Sarii; Matsuno, Yutaro; Mikamo, Akihito; Hamano, Kimikazu] Yamaguchi Univ, Dept Surg & Clin Sci, Div Cardiac Surg, Grad Sch Med, Ube, Yamaguchi 7558505, Japan.
C3 Yamaguchi University
RP Suzuki, R (通讯作者)，Yamaguchi Univ, Dept Surg & Clin Sci, Div Cardiac Surg, Grad Sch Med, Ube, Yamaguchi 7558505, Japan.
EM ryo-s@yamaguchi-u.ac.jp
OI Kurazumi, Hiroshi/0000-0002-4009-7391
FU Grants-in-Aid for Scientific Research [22K08960] Funding Source: KAKEN
CR HAKIMI M, 1994, J THORAC CARDIOV SUR, V107, P925
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NR 5
TC 5
Z9 5
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUN 15
PY 2022
VL 35
IS 1
DI 10.1093/icvts/ivac041
EA MAR 2022
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 2Q4PZ
UT WOS:000767455500001
PM 35257176
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hsu, KF
   Kao, LT
   Chu, PY
   Chen, CY
   Chou, YY
   Huang, DW
   Liu, TH
   Tsai, SL
   Wu, CW
   Hou, CC
   Wang, CH
   Dai, NT
   Chen, SG
   Tzeng, YS
AF Hsu, Kuo-Feng
   Kao, Li-Ting
   Chu, Pei-Yi
   Chen, Chun-Yu
   Chou, Yu-Yu
   Huang, Dun-Wei
   Liu, Ting-Hsuan
   Tsai, Sheng-Lin
   Wu, Chien-Wei
   Hou, Chih-Chun
   Wang, Chih-Hsin
   Dai, Niann-Tzyy
   Chen, Shyi-Gen
   Tzeng, Yuan-Sheng
TI Simple and Efficient Pressure Ulcer Reconstruction via Primary Closure
   Combined with Closed-Incision Negative Pressure Wound Therapy
   (CiNPWT)-Experience of a Single Surgeon
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE pressure ulcer; surgical reconstruction; dressing materials; wound
   control; negative pressure wound therapy; vacuum-assisted closure;
   closed-incision negative pressure wound therapy; closed-incision
   negative pressure therapy
ID ARTERY PERFORATOR FLAP; GENERAL-ANESTHESIA; OPEN ABDOMEN; MANAGEMENT;
   METAANALYSIS; PERFUSION; DEFECTS; SUTURES; SORES; CARE
AB Background: In this study, we aimed to analyze the clinical efficacy of closed-incision negative pressure wound therapy (CiNPWT) when combined with primary closure (PC) in a patient with pressure ulcers, based on one single surgeon's experience at our medical center. Methods: We retrospectively reviewed the data of patients with stage III or IV pressure ulcers who underwent reconstruction surgery. Patient characteristics, including age, sex, cause and location of defect, comorbidities, lesion size, wound reconstruction methods, operation time, debridement times, application of CiNPWT to reconstructed wounds, duration of hospital stay, and wound complications were analyzed. Results: Operation time (38.16 +/- 14.02 vs. 84.73 +/- 48.55 min) and duration of hospitalization (36.78 +/- 26.92 vs. 56.70 +/- 58.43 days) were shorter in the PC + CiNPWT group than in the traditional group. The frequency of debridement (2.13 +/- 0.98 vs. 2.76 +/- 2.20 times) was also lower in the PC + CiNPWT group than in the traditional group. The average reconstructed wound size did not significantly differ between the groups (63.47 +/- 42.70 vs. 62.85 +/- 49.94 cm(2)), and there were no significant differences in wound healing (81.25% vs. 75.38%), minor complications (18.75% vs. 21.54%), major complications (0% vs. 3.85%), or mortality (6.25% vs. 10.00%) between the groups. Conclusions: Our findings indicate that PC combined with CiNPWT represents an alternative reconstruction option for patients with pressure ulcers, especially in those for whom prolonged anesthesia is unsuitable.
C1 [Hsu, Kuo-Feng; Chen, Chun-Yu; Chou, Yu-Yu; Huang, Dun-Wei; Liu, Ting-Hsuan; Tsai, Sheng-Lin; Wu, Chien-Wei; Hou, Chih-Chun; Wang, Chih-Hsin; Dai, Niann-Tzyy; Chen, Shyi-Gen; Tzeng, Yuan-Sheng] Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Taipei 114202, Taiwan.
   [Hsu, Kuo-Feng; Chu, Pei-Yi; Chen, Chun-Yu; Chou, Yu-Yu; Huang, Dun-Wei; Liu, Ting-Hsuan; Tsai, Sheng-Lin; Wu, Chien-Wei; Hou, Chih-Chun; Wang, Chih-Hsin; Dai, Niann-Tzyy; Chen, Shyi-Gen; Tzeng, Yuan-Sheng] Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Taipei 114202, Taiwan.
   [Kao, Li-Ting] Triserv Gen Hosp, Natl Def Med Ctr, Dept Pharm Practice, Taipei 114202, Taiwan.
   [Kao, Li-Ting] Natl Def Med Ctr, Grad Inst Life Sci, Taipei 114202, Taiwan.
C3 National Defense Medical University; Tri-Service General Hospital;
   Tri-Service General Hospital; National Defense Medical University;
   National Defense Medical University; Tri-Service General Hospital;
   National Defense Medical University
RP Tzeng, YS (通讯作者)，Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Taipei 114202, Taiwan.; Tzeng, YS (通讯作者)，Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Taipei 114202, Taiwan.
EM captain0416@gmail.com; kaoliting@gmail.com; chu.peiyi.88@gmail.com;
   illusioncjy@gmail.com; justyu1112@gmail.com; gdream12731@gmail.com;
   liutingxuan@gmail.com; woodytsai2012@gmail.com;
   alex199180220@hotmail.com; i0937361709@hotmail.com;
   super-derrick@yahoo.com.tw; niantzyydai@gmail.com; shyigen@gmail.com;
   m6246kimo@yahoo.com.tw
RI ; Tzeng, Yuan-sheng/AAD-8843-2020; Kao, Li-Ting/W-9287-2018
OI Hou, Chih-Chun/0000-0002-7179-0551; Chu, Pei-yi/0000-0002-6905-7895;
   Tsai, Sheng-Lin/0000-0002-1591-1865; Wu, Chien-Wei/0000-0001-8798-2403;
   Liu, Ting-Hsuan/0000-0002-1482-978X; Tzeng,
   Yuan-sheng/0000-0002-8440-2351; Huang, Dun-Wei/0000-0002-5320-2517; Hsu,
   Kuo-Feng/0000-0002-6883-1295; Kao, Li-Ting/0000-0003-0692-7408
FU Tri-Service General Hospital [TSGH-E-110217 and TSGH-D-111124] Funding
   Source: Medline
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NR 54
TC 10
Z9 11
U1 2
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD FEB
PY 2022
VL 12
IS 2
AR 182
DI 10.3390/jpm12020182
PG 16
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA ZU2XX
UT WOS:000769708700001
PM 35207670
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chen, Z
   Sun, J
   Yao, ZP
   Song, CY
   Liu, WG
AF Chen, Zhi
   Sun, Jun
   Yao, Zhipeng
   Song, Chenyang
   Liu, Wenge
TI Can prophylactic negative pressure wound therapy improve clinical
   outcomes in spinal fusion surgery? A meta-analysis
SO EUROPEAN SPINE JOURNAL
LA English
DT Review
DE Negative pressure wound therapy; Prophylaxis; Postoperative
   complication; Spine surgery; Meta-analysis
ID SURGICAL SITE INFECTION; DEHISCENCE; QUALITY; TRIALS
AB Purpose Recently negative pressure wound therapy (NPWT) is increasingly being prophylactically used to prevent wound complications in various types of surgeries, but its role in spinal fusion surgery was less well established. This study aimed to evaluate the efficacy of prophylactic NPWT (PNPWT) usage in spinal fusion surgery. Methods Following PRISMA guidelines, databases PubMed, Embase and Web of Science were searched for relevant studies. Studies comparing PNPWT with standard wound dressing (SWD) were included and analyzed. The primary outcome was the incidence of surgical site infection, and secondary outcomes were incidence of wound dehiscence, overall wound complication, readmission and reoperation. Results A total of five studies were included; there were 279 patients in PNPWT group and 715 patients in SWD group. Four studies investigated surgical site infection; the pooled analysis showed a significantly lower incidence of surgical site infection in PNPWT group (OR: 0.399; 95% CI: 0.198, 0.802). Two studies explored wound dehiscence, three studies reported overall wound complication, and there were no significant differences between the two groups ((OR: 0.448; 95% CI: 0.144, 1.389) and (OR: 0.562; 95% CI: 0.296, 1.065), respectively). Two studies evaluated readmission, three studies compared reoperation rate, and the pooled results demonstrated no significant difference between the two groups ((OR: 1.045; 95% CI: 0.536, 2.038) and (OR: 0.979; 95% CI: 0.442, 2.169), respectively). Conclusions The current evidence suggested PNPWT could effectively reduce postoperative surgical site infection, but it had no significant benefit on reducing the incidence of wound dehiscence, overall wound complication, readmission and reoperation.
C1 [Chen, Zhi; Yao, Zhipeng; Song, Chenyang; Liu, Wenge] Fujian Med Univ Union Hosp, Dept Orthoped Surg, Fuzhou 350001, Fujian, Peoples R China.
   [Sun, Jun] Zhaotong Tradit Chinese Med Hosp, Dept Emergency, Zhaotong 657000, Yunnan, Peoples R China.
C3 Fujian Medical University
RP Liu, WG (通讯作者)，Fujian Med Univ Union Hosp, Dept Orthoped Surg, Fuzhou 350001, Fujian, Peoples R China.
EM lwgspine@126.com
RI Chen, Zhi/PKR-2689-2026; song, chenyang/KMA-2573-2024
OI Chen, Zhi/0000-0003-0099-0916; Liu, Wenge/0000-0003-2128-1908; Sun,
   Jun/0009-0006-1534-0122; 
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NR 20
TC 14
Z9 18
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0940-6719
EI 1432-0932
J9 EUR SPINE J
JI Eur. Spine J.
PD JUN
PY 2022
VL 31
IS 6
BP 1546
EP 1552
DI 10.1007/s00586-022-07178-y
EA MAR 2022
PG 7
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 2D8IF
UT WOS:000770719200001
PM 35306599
DA 2026-07-24
ER
PT J
AU Oshima, J
   Sasaki, K
   Aihara, Y
   Sasaki, M
   Shibuya, Y
   Inoue, Y
   Sekido, M
AF Oshima, Junya
   Sasaki, Kaoru
   Aihara, Yukiko
   Sasaki, Masahiro
   Shibuya, Yoichiro
   Inoue, Yoshiaki
   Sekido, Mitsuru
TI Combination of Three Different Negative Pressure Wound Therapy
   Applications and Free Flap for Open Elbow Joint Injury With Extensive
   Burns
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID SKIN-GRAFT; DONOR SITE; MANAGEMENT
AB Negative pressure wound therapy (NPWT) for treating burns has a variety of therapeutic applications. Here, we present a case of a 53-year-old woman with self-inflicted burn injuries in whom NPWT was applied for three different purposes. The injured sites were the anterior neck, bilateral arms from the wrists upwards to the chest, and back. The left arm was deeply injured, and the elbow joint cavity was opened during treatment. First, NPWT was used for bridge to skin grafting on the entire upper left limb. Second, NPWT was used as a bolster dressing for the autograft after skin grafting was performed on the left arm except the open part of the joint. Third, NPWT over flap was used on the subsequent flap surgical site to address prolonged exudate from the flap margin. The exudate resolved after about a week. Good results were obtained using NPWT during the perioperative period of free flap transplantation for extensive open elbow joint burns. The use of NPWT is an effective option in the treatment of burns.
C1 [Oshima, Junya; Sasaki, Kaoru; Aihara, Yukiko; Sasaki, Masahiro; Shibuya, Yoichiro; Sekido, Mitsuru] Univ Tsukuba, Dept Plast & Reconstruct Surg, Tsukuba, Ibaraki, Japan.
   [Inoue, Yoshiaki] Univ Tsukuba, Dept Emergency & Crit Care Med, Tsukuba, Ibaraki, Japan.
C3 University of Tsukuba; University of Tsukuba
RP Oshima, J (通讯作者)，Univ Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan.
EM ooshima-tuk@umin.ac.jp
OI Oshima, Junya/0000-0003-4814-0849
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NR 20
TC 2
Z9 3
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR 23
PY 2022
VL 43
IS 2
BP 479
EP 482
DI 10.1093/jbcr/irab228
EA DEC 2021
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA ZY5BX
UT WOS:000772602800028
PM 34865037
DA 2026-07-24
ER
PT J
AU Luo, HM
   Chi, YF
   Chen, X
   Chai, JK
AF Luo, Hongmin
   Chi, Yunfei
   Chen, Xin
   Chai, Jiake
TI Usage of Negative Pressure Wound Therapy in Pseudoepitheliomatous
   Hyperplasia Secondary to Burn Injury: A Case Series
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
AB Pseudoepitheliomatous hyperplasia (PEH) is a reactive epithelial proliferation secondary to a wide range of stimuli, including traumatic injury, inflammation, infection, and tumors of the skin. PEH secondary to burn injury is rarely reported. We report three cases of PEH patients after burn injury. All three cases were confirmed with the existence of bacterial infection, and all these cases were second- or third-degree burns. All three patients were treated with negative pressure wound therapy after wound debridement or tangential excision. All the wounds healed without split-thickness skin grafting and recurrence.
C1 [Luo, Hongmin] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Burns & Wound Repair Surg, Guangzhou, Guangdong, Peoples R China.
   [Chi, Yunfei; Chen, Xin; Chai, Jiake] Peoples Liberat Army Gen Hosp, Burn Inst, Med Ctr 4, 51 Fu Cheng Rd, Beijing 100048, Peoples R China.
C3 Guangdong Academy of Medical Sciences & Guangdong General Hospital;
   Southern Medical University - China; Chinese People's Liberation Army
   General Hospital
RP Chi, YF (通讯作者)，Peoples Liberat Army Gen Hosp, Burn Inst, Med Ctr 4, 51 Fu Cheng Rd, Beijing 100048, Peoples R China.
EM chi_yunfei@126.com
RI Luo, Hongmin/ABG-6510-2021
FU People's Liberation Army General Hospital Big Data Project "The
   establishment of emergency clinical database for burn and study of scar
   prediction model" [2019MBD-054]
FX People's Liberation Army General Hospital Big Data Project "The
   establishment of emergency clinical database for burn and study of scar
   prediction model" (2019MBD-054).
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NR 11
TC 1
Z9 1
U1 1
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR 23
PY 2022
VL 43
IS 2
BP 492
EP 495
DI 10.1093/jbcr/irab207
EA NOV 2021
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA ZY5BX
UT WOS:000772602800031
PM 34695202
DA 2026-07-24
ER
PT J
AU James, CV
   Patel, M
   Ellis, S
   Dudkiewicz, M
   Benvenisty, A
   Lantis, JC 
AF James, Crystal, V
   Patel, Munir
   Ellis, Scott
   Dudkiewicz, Michael
   Benvenisty, Alan
   Lantis, John C., II
TI The Use of Fetal Bovine Collagen on Chronic Wounds Increases Limb
   Salvage: A Single-center Retrospective Analysis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE cellular- and tissue-based therapy; fetal bovine collagen; amputation;
   chronic wound; lower extremity wound; infection; limb salvage
ID DIABETIC FOOT
AB Objective. As part of a quality assurance project at a large tertiary care surgical program in New York City, the effect of debridement, negative pressure wound therapy, and cellular.- and tissue-based products (CTPs) on limb salvage was evaluated based on the following outcomes: freedom from amputation, wound closure, and freedom from readmission. Fetal bovine collagen was among the CTPs evaluated. Materials and Methods. The data used in this study were derived from a database of all patients who had undergone procedures involving placement of a dermal matrix at the center over a 2.5-year period (January 2016-June 2018). This retrospective analysis included 256 patients who underwent debridement and/or placement of a CTP as part of the treatment course for chronic wounds. Results. Of the 252 patients identified, 34 required either minor or major all-cause amputation from the initial wound intervention, whereas for 218 patients, there were no recorded amputations through the end of the study period after the initial wound intervention. When fetal bovine collagen was evaluated as an explanatory variable to the presence of future amputation, a statistically significant relationship between the variables was found. Conclusions. The results of the current data analysis indicate that a treatment algorithm that includes appropriate antibiotic therapy, tangential hydrosurgery, application of fetal bovine collagen, and a short course of negative pressure wound therapy may be a more favorable option to achieve limb salvage, freedom from readmission, and wound closure.
C1 [James, Crystal, V; Patel, Munir; Ellis, Scott] Mt Sinai Morningside West Hosp, Gen Surg, New York, NY 10025 USA.
   [Dudkiewicz, Michael; Benvenisty, Alan; Lantis, John C., II] Mt Sinai Morningside West Hosp, Icahn Sch Med Mt Sinai, Div Vasc Surg, New York, NY USA.
C3 Icahn School of Medicine at Mount Sinai
RP James, CV (通讯作者)，Mt Sinai Morningside West Hosp, 425 W 59th St,Floor 7, New York, NY 10025 USA.
EM Crystal.James2@mountsinai.org
RI Benvenisty, Alan/LTD-8563-2024
CR Driver VR, 2010, J VASC SURG, V52, p17S, DOI 10.1016/j.jvs.2010.06.003
   Driver VR, 2005, DIABETES CARE, V28, P248, DOI 10.2337/diacare.28.2.248
   Frykberg RG, 2015, ADV SKIN WOUND CARE, V28, P17, DOI 10.1097/01.ASW.0000456630.12766.e9
   Jeyaraman K, 2019, BMC ENDOCR DISORD, V19, DOI 10.1186/s12902-018-0327-2
   Nussbaum SR, 2018, VALUE HEALTH, V21, P27, DOI 10.1016/j.jval.2017.07.007
   Santema TBK, 2016, WOUND REPAIR REGEN, V24, P737, DOI 10.1111/wrr.12434
   Veves A, 2001, DIABETES CARE, V24, P290, DOI 10.2337/diacare.24.2.290
NR 7
TC 1
Z9 1
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2022
VL 34
IS 3
BP 71
EP 74
DI 10.25270/wnds/2022.7174
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 0B2XV
UT WOS:000774504700001
PM 35273124
DA 2026-07-24
ER
PT J
AU Bachmann, J
   Feith, M
   Schlag, C
   Abdelhafez, M
   Martignoni, ME
   Friess, H
AF Bachmann, Jeannine
   Feith, Marcus
   Schlag, Christoph
   Abdelhafez, Mohamed
   Martignoni, Marc E.
   Friess, Helmut
TI Anastomotic leakage following resection of the esophagus-introduction of
   an endoscopic grading system
SO WORLD JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE Anastomotic leakage; Endoscopic grading system; Endoluminal vacuum
   therapy
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE COMPLICATIONS; SURVIVAL;
   ESOPHAGECTOMY; CANCER
AB Background Malignant tumors of the esophagus are the sixth leading cause of cancer-related deaths worldwide. Postoperative leakage of the esophago-gastrostomy leads to mediastinal sepsis, which is still associated with a high morbidity and mortality rate. The aim of this study was to describe the endoscopic view of the different severity grades of an anastomotic leakage. Methods Patients Between June 2016 and September 2018, 144 patients were operated upon in the Department of Surgery, University of Munich, Germany. Among these patients, 34 (23.6%) presented with a leakage of the anastomosis. Endoscopy In this retrospective analysis, the focus is to describe different patterns of leakage of the anastomosis. Results We studied 34 patients in whom post-esophagectomy leakage of the anastomosis was detected and treated with an endoluminal vacuum sponge system. The leakage healed in 26 of 29 patients (success rate 89.7%). With the increasing severity of leakage, the treatment time and the in-hospital mortality correspondingly increased. Furthermore, the incidence of the development of a fistula to the tracheobronchial system increased with higher grades of leakage. Conclusions Exact descriptions of leakage are necessary to compare the cases and to prove post-treatment improvement. This is, to our knowledge, the first publication to present a leakage grading score in patients after esophagectomy including reconstruction with a gastric tube. This new grading system needs to be tested in further analyses, with a special focus on prospective analysis.
C1 [Bachmann, Jeannine; Feith, Marcus; Martignoni, Marc E.; Friess, Helmut] Tech Univ Munich, Dept Surg, Klinikum Rechts Isar, D-81675 Munich, Germany.
   [Schlag, Christoph; Abdelhafez, Mohamed] Tech Univ Munich, Dept Internal Med, Klinikum Rechts Isar, Ismaningerstr 22, D-81675 Munich, Germany.
C3 Technical University of Munich; Technical University of Munich
RP Bachmann, J (通讯作者)，Tech Univ Munich, Dept Surg, Klinikum Rechts Isar, D-81675 Munich, Germany.
EM jeannine.bachmann@tum.de
RI Schlag, Christoph/KXR-8170-2024; Abdelhafez, Mohamed/Y-6676-2019;
   Friess, Helmut/ABO-1348-2022
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
CR Alldinger I, 2015, LANGENBECK ARCH SURG, V400, P9, DOI 10.1007/s00423-014-1257-8
   Andreou A, 2016, SURGERY, V160, P191, DOI 10.1016/j.surg.2016.02.020
   Booka E, 2018, BJS OPEN, V2, P276, DOI 10.1002/bjs5.64
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Goense L, 2017, DIS ESOPHAGUS, V30, DOI 10.1111/dote.12517
   Hagens ERC, 2018, ANN THORAC SURG, V106, P1702, DOI 10.1016/j.athoracsur.2018.05.009
   van den Bergh Roderick C N, 2009, Cancer, V115, P3868, DOI [10.3322/caac.20107, 10.1002/cncr.24446]
   Rasmussen SR, 2018, J THORAC DIS, V10, P4052, DOI 10.21037/jtd.2018.07.04
   Schniewind B, 2013, SURG ENDOSC, V27, P3883, DOI 10.1007/s00464-013-2998-0
   Siewert JR, 2003, WORLD J SURG, V27, P1058, DOI 10.1007/s00268-003-7061-1
   Torre LA, 2015, CA-CANCER J CLIN, V65, P87, DOI 10.3322/caac.21262
   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Wedemeyer J, 2010, GASTROINTEST ENDOSC, V71, P382, DOI 10.1016/j.gie.2009.07.011
NR 13
TC 13
Z9 13
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7819
J9 WORLD J SURG ONCOL
JI World J. Surg. Oncol.
PD MAR 31
PY 2022
VL 20
IS 1
AR 104
DI 10.1186/s12957-022-02551-z
PG 6
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 0D5KK
UT WOS:000776033800002
PM 35354483
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Grimstad, O
AF Grimstad, Oystein
TI Single use negative-pressure wound therapy compared to standard care in
   patients after carbon dioxide laser surgery for hidradenitis suppurativa
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE carbon dioxide laser; negative-pressure wound therapy; patient-reported
   outcomes
AB Negative pressure wound therapy is a commonly used treatment modality for surgical wounds healing by secondary intention. In an open, split side study with 12 patients, we compared low negative pressure wound therapy to conventional foam dressing the first postoperative week after carbon dioxide laser vaporization of hidradenitis suppurativa lesions. The primary outcome was time to complete wound healing, comparing the two intervention sites. Secondary endpoints included perception of pain during intervention period and patient registered impact of the regimes on daily life activities. Low negative pressure wound therapy the first postoperative week tended to reduce the time to complete wound healing. Patients reported significant lower pain levels from wounds treated with a negative pressure wound device the first postoperative week. Eleven out of 12 study participants had a preference to the negative pressure wound therapy regime to a conventional regime with foam dressings.
C1 [Grimstad, Oystein] Univ Hosp North Norway, Dept Dermatol, Tromso, Norway.
   [Grimstad, Oystein] UiT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
C3 UiT The Arctic University of Tromso; University Hospital of North
   Norway; UiT The Arctic University of Tromso
RP Grimstad, O (通讯作者)，Univ Hosp North Norway, Dept Dermatol, Tromso, Norway.
EM oystein.grimstad@unn.no
RI Gritad, Øystein/AAE-7596-2021
OI Gritad, Øystein/0000-0001-6783-4534
FU University Hospital of North Norway
FX The study was fully funded by the University Hospital of North Norway.
CR Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Coll AM, 2004, J ADV NURS, V46, P124, DOI 10.1111/j.1365-2648.2003.02972.x
   Dini V, 2015, INT J LOW EXTR WOUND, V14, P236, DOI 10.1177/1534734615598890
   Dumville JC, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011278.pub2
   Grimstad O, 2019, J EUR ACAD DERMATOL, V33, P1164, DOI 10.1111/jdv.15353
   Hudson DA, 2015, INT WOUND J, V12, P195, DOI 10.1111/iwj.12080
   Hurd, 2013, EVALUATING COSTS BEN
   Hurd T, 2014, OSTOMY WOUND MANAG, V60, P30
   Institute for Quality and Efficiency in Health Care (IQWiG), 2019, IQWiG Reports-Commission No. N17-01B: Negative pressure wound therapy for wounds healing by primary intention
   KUNDIN JI, 1989, AM J NURS, V89, P206, DOI 10.2307/3471091
   Lapins J, 2002, J AM ACAD DERMATOL, V47, P280, DOI 10.1067/mjd.2002.124601
   Mikkelsen PR, 2015, DERMATOL SURG, V41, P255, DOI 10.1097/DSS.0000000000000264
   Vermeulen H, 2005, BJS-BRIT J SURG, V92, P665, DOI 10.1002/bjs.5055
   Zens Y, 2020, SYST REV-LONDON, V9, DOI 10.1186/s13643-020-01476-6
   Zouboulis CC, 2015, J EUR ACAD DERMATOL, V29, P619, DOI 10.1111/jdv.12966
NR 15
TC 4
Z9 6
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD JUN
PY 2022
VL 35
IS 6
AR e15483
DI 10.1111/dth.15483
EA APR 2022
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1W8LN
UT WOS:000778503300001
PM 35373495
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Révész, ES
   Altorjay, A
   Montskó, V
   Hangody, L
AF Revesz, Erzsebet Szabone
   Altorjay, Aron
   Montsko, Valeria
   Hangody, Laszlo
TI Effectiveness of negative pressure wound therapy: Minimum five-year
   follow-up and review of the literature
SO JOINT DISEASES AND RELATED SURGERY
LA English
DT Article
DE Efficacy; negative pressure wound therapy; wound management
AB Objectives: In this study, we aimed to assess the effectiveness of negative pressure wound therapy (NPWT) in a five-year patient cohort and to discuss the results in the light of literature data. Patients and methods: Between January 2012 and December 2016, a total of 74 patients (35 males, 39 females; median age: 60 years; range, 20 to 95 years) who received NPWT were retrospectively analyzed. The patients included 49 orthopedic and traumatology, 12 vascular surgery, and 13 general surgery patients. The efficacy of wound healing, bacterial load, and the impact of comorbidities on wound healing were examined. Results: The distribution of wound types varied very widely. Certain comorbidities affected wound healing. In orthopedic traumatology patients, we observed mainly skin flora infection (57.14%), while in surgical and vascular patients, mixed flora (80%) and in many cases poly-resistant pathogens were present (methicillin-resistant Staphylococcus aureus 24%) A total of 43.3% of wounds were completely closed, while 44.6% of patients had a wound healing. Successful skin grafting was performed in 75% of wounds. Conclusion: This technique may be used as widely and as early as possible. However, further large-scale, multi-center, randomized clinical trials are needed worldwide to find a place for this technique in wound care and even in primary care.
C1 [Revesz, Erzsebet Szabone; Altorjay, Aron] St Goerges Hosp, Dept Surg, H-8000 Szekesfehervar, Hungary.
   [Montsko, Valeria] St George Hosp, Septiv, Szekesfehervar, Hungary.
   [Hangody, Laszlo] Uzsoki Hosp, Dept Orthoped & Traumatol, Budapest, Hungary.
   [Hangody, Laszlo] Semmelweis Univ, Dept Traumatol, Budapest, Hungary.
C3 Semmelweis University
RP Révész, ES (通讯作者)，St Goerges Hosp, Dept Surg, H-8000 Szekesfehervar, Hungary.
EM revesze1978@gmail.com
OI Szabone Dr. Revesz, Erzsebet/0000-0002-6054-8508
CR Älgå A, 2022, WORLD J EMERG SURG, V17, DOI 10.1186/s13017-022-00415-1
   Atik OS, 2020, JOINT DIS RELAT SURG, V31, P597, DOI 10.5606/ehc.2020.57896
   Gok Mehmet Ali, 2019, J Med Life, V12, P276, DOI [10.25122/jml-2019-0033, 10.25122/jml-2019-0033]
   Jensen NM., 2022, J CLIN ORTHOPAEDICS, V24, P101710, DOI [10.1016/j.jcot.2021.101710, DOI 10.1016/J.JCOT.2021.101710]
   Kwon J, 2018, J VASC SURG, V68, P1744, DOI 10.1016/j.jvs.2018.05.224
   Liu X, 2018, INT J SURG, V53, P72, DOI 10.1016/j.ijsu.2018.02.064
   Liu ZM, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010318.pub3
   Maruccia M, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/8395219
   Norman G, 2020, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD009261.pub6, 10.1002/14651858.CD009261.pub5]
   Qiu E, 2018, J PLAST SURG HAND SU, V52, P259, DOI 10.1080/2000656X.2018.1470979
   Rached A., 2019, Negative Pressure Therapy: Theoretical Knowledg and Practical Application, V1st ed.
   Revesz Szabone E., 2021, KH, P506
   Rys P, 2020, ENDOCRINE, V68, P44, DOI 10.1007/s12020-019-02164-9
   Song YP, 2021, WOUND REPAIR REGEN, V29, P20, DOI 10.1111/wrr.12863
   Verma H, 2015, INT WOUND J, V12, P317, DOI 10.1111/iwj.12110
   Wang C, 2019, J ORTHOP SURG RES, V14, DOI 10.1186/s13018-019-1488-z
   Wu LJ, 2022, INT WOUND J, V19, P1449, DOI 10.1111/iwj.13741
NR 17
TC 15
Z9 17
U1 0
U2 4
PU TURKISH JOINT DISEASES FOUNDATION
PI CANKAYA
PA MUSTAFA KEMAL MAHALLESI, DUMLUPINAR BULVARI 274-2 C2 BLOK OFIS, 5,
   CANKAYA, ANKARA, TURKEY
SN 2687-4784
EI 2687-4792
J9 JOINT DIS RELAT SURG
JI Joint Dis. Relat. Surg.
PY 2022
VL 33
IS 1
BP 51
EP 56
DI 10.52312/jdrs.2022.547
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 0H8DQ
UT WOS:000778960800008
PM 35361080
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kabir, I
   Nguyen, T
   Heaton, J
   Peterson, K
   Martyak, M
AF Kabir, Ishraq
   Nguyen, Tuan
   Heaton, Julia
   Peterson, Kristen
   Martyak, Michael
TI Incisional Negative Pressure Wound Therapy to Decrease the Incidence of
   Surgical Site Infections in Trauma Laparotomy Wounds
SO AMERICAN SURGEON
LA English
DT Article
AB Background Surgical site infection (SSI) is a common post-operative complication, especially in trauma laparotomies. Incisional negative pressure wound therapy (iNPWT) is a novel technique in reducing SSIs. We aim to study the rate of wound complications in trauma laparotomy with standard primary closure with staples vs iNPWT. Methods We had 152 patients meeting inclusion criteria who underwent emergent trauma laparotomies performed at Sentara Norfolk General from 2017 to 2020. We had 79 patients in the standard staple group and 73 patients in the iNWPT group. We then analyzed surgical site infection rates and wound complication rates in both groups within a 30-day period. Results The wound infection rate in the staple vs staple plus iNPWT was 10.0% vs 3.8%, respectively (P = .13). Wound dehiscence rates were 24.1% vs 10.13%, respectively (P = .02). When looking at a subset of patients with hollow viscous injury, the rate of SSIs was statistically lower in the iNPWT group. Prior to the introduction of the incisional vacuum-assisted closure (VAC) to our practice compared to after its introduction, 39.25% of wounds were left open vs 19.51%, respectively (P = .001). Conclusion Our data identified a trend toward a decrease in overall SSIs in trauma laparotomies closed with iNPWT. The use of iNPWT demonstrated a decrease in superficial wound dehiscence and a decrease in SSIs in patients with associated full thickness bowel injury. With iNPWT, we are more aggressive with primarily closing trauma laparotomy wounds. This shows promise for increasing primary closure rates while simultaneously decreasing overall superficial surgical site infection rate.
C1 [Kabir, Ishraq; Nguyen, Tuan; Heaton, Julia; Peterson, Kristen; Martyak, Michael] Eastern Virginia Med Sch, Hoffheimer Hall,825 Fairfax Ave,Suite 610, Norfolk, VA 23501 USA.
C3 Eastern Virginia Medical School
RP Kabir, I (通讯作者)，Eastern Virginia Med Sch, Hoffheimer Hall,825 Fairfax Ave,Suite 610, Norfolk, VA 23501 USA.
EM Ishraqkabir4@gmail.com
CR Chadi SA, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0817-8
   Durbin S, 2019, J SURG RES, V243, P496, DOI 10.1016/j.jss.2019.06.101
   Gomoll AH, 2006, J ORTHOP TRAUMA, V20, P705, DOI 10.1097/01.bot.0000211159.98239.d2
   Hall C, 2019, J AM COLL SURGEONS, V228, P393, DOI 10.1016/j.jamcollsurg.2018.12.006
   Ke CY, 2017, J BIOMED INFORM, V65, P22, DOI 10.1016/j.jbi.2016.10.021
   Morales CH, 2011, CAN J SURG, V54, P17, DOI 10.1503/cjs.022109
NR 6
TC 5
Z9 5
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD MAY
PY 2023
VL 89
IS 5
BP 1908
EP 1911
AR 00031348211054529
DI 10.1177/00031348211054529
EA APR 2022
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J0VE5
UT WOS:000779358900001
PM 35384733
DA 2026-07-24
ER
PT J
AU Cheung, DC
   Muaddi, H
   de Almeida, JR
   Finelli, A
   Karanicolas, P
AF Cheung, Douglas C.
   Muaddi, Hala
   de Almeida, John R.
   Finelli, Antonio
   Karanicolas, Paul
TI Cost-Effectiveness Analysis of Negative Pressure Wound Therapy to
   Prevent Surgical Site Infection After Elective Colorectal Surgery
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE Cost-effectiveness; Negative pressure wound therapy; Surgical site
   infection
ID INCISIONAL HERNIA; RISK-FACTORS; IMPACT; READMISSIONS; VISITS
AB BACKGROUND: Surgical site infection is common after colorectal surgery and is associated with increased costs. Prophylactic negative pressure wound therapy has previously been shown to reduce surgical site infection compared with conventional dressings. However, negative pressure wound therapy application is met with hesitancy because of its additional cost.
   OBJECTIVE: This study aims to determine whether the application of prophylactic negative pressure wound therapy after elective colorectal surgery is cost-effective.
   DESIGN: A cost-effectiveness analysis comparing prophylactic negative pressure wound therapy versus conventional dressing was completed using a Markov microsimulation model. A publicly funded single health care payer perspective was adopted across a lifetime horizon.
   SETTING: This study was conducted using in-hospital elective colorectal surgery.
   PATIENTS: The base case was an age-, sex-, and comorbidity-standardized patient undergoing open elective colorectal surgery.
   INTERVENTION: Negative pressure wound therapy was applied postoperatively over closed incisions.
   MAIN OUTCOMES: The primary outcomes of interest were the number of surgical site infections, total costs, and quality-adjusted life-years gained. Secondary outcomes included emergency department presentation, hospital readmission, nursing wound care utilization, fascial dehiscence, incisional hernia, and non-surgical site infection-related complications.
   RESULTS: We found that prophylactic negative pressure wound therapy, standardized to 1000 patients, prevented 51 surgical site infections, 3 fascial dehiscences, 10 incisional hernias, 22 emergency department presentations, and 6 hospital readmissions. This resulted in a total cost saving of $17,066 and 92.2 quality-adjusted life-years gained ($17.07 and 0.09 quality-adjusted life-years gained on average per patient). When the patients' risk of surgical site infections was greater than 3.2%, negative pressure wound therapy was a cost-effective strategy at a willingness to pay of $50,000/quality-adjusted life-years.
   LIMITATIONS: We did not model for societal perspective, emergent presentations of incarcerated hernias, or complications with hernia repair. The results of this model are reliant on the published negative pressure wound therapy efficacy and may change when additional data arise.
   CONCLUSION: The use of negative pressure wound therapy is the dominant strategy with improved outcomes and reduced costs compared with conventional dressing in patients undergoing colorectal surgery, particularly in at-risk patients.
C1 [Cheung, Douglas C.; Muaddi, Hala; de Almeida, John R.; Finelli, Antonio; Karanicolas, Paul] Univ Toronto, Dept Surg, Toronto, ON, Canada.
   [de Almeida, John R.] Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada.
   [Finelli, Antonio] Univ Toronto, Univ Hlth Network, Princess Margaret Canc Ctr, Div Urol,Dept Surg, Toronto, ON, Canada.
   [de Almeida, John R.; Karanicolas, Paul] Sunnybrook Hlth Sci Ctr, Div Gen Surg, Toronto, ON, Canada.
   [Karanicolas, Paul] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; University of Toronto;
   University Health Network Toronto; Princess Margaret Cancer Centre;
   University of Toronto; Sunnybrook Health Science Center; Sunnybrook
   Research Institute; University of Toronto
RP Karanicolas, P (通讯作者)，Sunnybrook Hlth Sci Ctr, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada.
EM paul.karanicolas@sunnybrook.ca
RI Muaddi, Hala/AAE-1264-2021
CR Amri R, 2017, JAMA SURG, V152, P686, DOI 10.1001/jamasurg.2017.0505
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   Walming S, 2017, BMC SURG, V17, DOI 10.1186/s12893-017-0207-0
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
   Wilson MZ, 2016, AM J SURG, V212, P844, DOI 10.1016/j.amjsurg.2015.12.025
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   Young H, 2012, J AM COLL SURGEONS, V214, P852, DOI 10.1016/j.jamcollsurg.2012.01.041
NR 32
TC 2
Z9 4
U1 2
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD MAY
PY 2022
VL 65
IS 5
BP 767
EP 776
DI 10.1097/DCR.0000000000002154
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 0I5JN
UT WOS:000779456900037
PM 34840300
DA 2026-07-24
ER
PT J
AU Bloom, JA
   Tian, TN
   Homsy, C
   Singhal, D
   Salehi, P
   Chatterjee, A
AF Bloom, Joshua A.
   Tian, Tina
   Homsy, Christopher
   Singhal, Dhruv
   Salehi, Payam
   Chatterjee, Abhishek
TI A Cost-Utility Analysis of the Use of Closed-Incision Negative Pressure
   System in Vascular Surgery Groin Incisions
SO AMERICAN SURGEON
LA English
DT Article
DE cost-utility; cost-effectiveness; femoral-popliteal bypass;
   closed-incision negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; COMPONENTS SEPARATION;
   INFECTION; COMPLICATIONS; PREVENTION; MANAGEMENT; RECONSTRUCTION;
   PERSPECTIVE; MESH
AB Objective Closed-incision negative pressure therapy (CINPT) with the Prevena system has been used and clinically evaluated in high-risk groin incisions to reduce the risk of postoperative complications. We performed a cost-effectiveness analysis evaluating CINPT in femoral-popliteal bypass with prosthetic graft. Methods A literature review looking at prospective randomized trials determined the probabilities and outcomes for femoral-popliteal bypass with and without CINPT. Reported utility scores were used to estimate the quality adjusted life years (QALYs) associated with a successful procedure and postoperative complications. Medicare current procedure terminology and diagnosis-related group codes were used to assess the costs for a successful surgery and associated complications. A decision analysis tree was constructed with rollback analysis to highlight the more cost-effective strategy. An incremental cost-effectiveness ratio (ICER) analysis was performed with a willingness to pay at $50,000. Deterministic and probabilistic sensitivity analyses were performed to validate the robustness of the results, and to accommodate for the uncertainty in the literature. Results Femoral-popliteal bypass with CINPT is less costly ($40,138 vs $41,774) and more effective (6.14 vs 6.13) compared to without CINPT. This resulted in a negative ICER of -234,764.03, which favored CINPT, indicating a dominant strategy. In one-way sensitivity analysis, surgery without CINPT was more cost-effective if the probability of successful surgery falls below 84.9% or if the cost of CINPT exceeds $3139. Monte Carlo analysis showed a confidence of 99.07% that CINPT is more cost-effective. Conclusions Despite the added device cost of CINPT, it is cost-effective in vascular surgical operations using groin incisions.
C1 [Bloom, Joshua A.; Tian, Tina] Tufts Med Ctr, Dept Surg, 800 Washington St, Boston, MA 02111 USA.
   [Homsy, Christopher; Chatterjee, Abhishek] Tufts Med Ctr, Div Plast & Reconstruct Surg, Dept Surg, Boston, MA 02111 USA.
   [Singhal, Dhruv] Beth Israel Deaconess Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, 330 Brookline Ave, Boston, MA 02215 USA.
   [Salehi, Payam] Tufts Med Ctr, Div Vasc Surg, Dept Surg, Boston, MA 02111 USA.
C3 Tufts Medical Center; Tufts Medical Center; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Tufts Medical Center
RP Bloom, JA (通讯作者)，Tufts Med Ctr, Dept Surg, 800 Washington St, Boston, MA 02111 USA.
EM bloomjosha@gmail.com
RI Bloom, Joshua/W-6427-2019; Salehi, Payam/AAP-6921-2021
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   Svensson-Björk R, 2019, BJS-BRIT J SURG, V106, P310, DOI 10.1002/bjs.11100
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   Vargo D, 2012, AM J SURG, V204, P1021, DOI 10.1016/j.amjsurg.2012.10.004
NR 46
TC 10
Z9 10
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JUN
PY 2023
VL 89
IS 6
BP 2237
EP 2246
AR 00031348221087395
DI 10.1177/00031348221087395
EA APR 2022
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA N6RL5
UT WOS:000780163200001
PM 35392664
DA 2026-07-24
ER
PT J
AU Alreshaid, F
   Aljehani, Y
AF Alreshaid, Farouk
   Aljehani, Yasser
TI Modified application of vacuum-assisted closure in thoracic surgery
   patients
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE intrapleural; negative pressure; pleural; SSI; surgical site infection;
   thoracic surgery; vacuum-assisted closure; VAC therapy; wound; wound
   care; wound dressing; wound healing
ID MANAGEMENT; THERAPY; EMPYEMA
AB Objective: Surgical site infection (SSI), ranging from superficial, deep and to organ space, is one of the major predictors for morbidity and mortality in patients undergoing thoracic surgery. Care to accelerate SSI healing is taken to shorten hospital stay and reduce costs. The deep application of vacuum-assisted closure (VAC) in thoracic patients is not well established in the literature. In this study, the deep application and safety of VAC therapy in patients with various thoracic pathologies was evaluated.
   Method: A retrospective chart review of all patients who were admitted to the thoracic surgery service between July 2014 and July 2018 and who developed deep SSI was carried out.
   Results: A total of 12 patients were included, and their demographic data analysed. There were various thoracic pathologies complicated with postoperative deep SSI treated with VAC. The duration of VAC application ranged from 4-40 days with an average hospital stay of 37.6 days. All patients showed clinical, radiological and microbiological improvement rather than developing complications except for one case of mortality due to septicaemia.
   Conclusion: In this study, partial intrapleural VAC therapy was safe for use in patients who underwent thoracic surgery, regardless of the underling pathology, with caution (i.e., with continued monitoring of the patient's tolerance to the treatment). The overall hospital stay may be reduced with the use of VAC. It also decreased perioperative morbidity, secondary to wound infection.
C1 [Alreshaid, Farouk; Aljehani, Yasser] Imam Abdulrahman Bin Faisal Univ, Dept Surg, Coll Med, Thorac Surg Div,King Fahad Hosp Univ, Dammam, Saudi Arabia.
C3 Imam Abdulrahman Bin Faisal University
RP Alreshaid, F (通讯作者)，Imam Abdulrahman Bin Faisal Univ, Dept Surg, Coll Med, Thorac Surg Div,King Fahad Hosp Univ, Dammam, Saudi Arabia.
EM freshaid@iau.edu.sa
CR Aljehani Y, 2016, CASE REP SURG, V2016, DOI 10.1155/2016/6805736
   Altintas B, 2015, INT WOUND J, V12, P662, DOI 10.1111/iwj.12198
   Cafarotti S, 2017, Chest Drains Daily Clin Pract, P17, DOI [10.1007/978-3-319-32339-8_2, DOI 10.1007/978-3-319-32339-8_2]
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   Groetzner J, 2009, THORAC CARDIOV SURG, V57, P417, DOI 10.1055/s-0029-1185907
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NR 13
TC 1
Z9 1
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2022
VL 31
IS 4
SU 4
BP S5
EP S9
DI 10.12968/jowc.2022.31.Sup4.S5
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0L6OQ
UT WOS:000781592400002
PM 35404712
DA 2026-07-24
ER
PT J
AU Netto, FACS
   Becker, MJ
   Bertoldi, A
   Shiroma, HS
   Barreto, H
   Ribeiro, MAF Jr
AF Spencer Netto, Fernando A. C.
   Becker, Mariana J.
   Bertoldi, Ayessa
   Shiroma, Henrique S.
   Barreto, Hemanuelli
   Fontenelle Ribeiro Jr, Marcelo Augusto
TI Combined use of progressive tension suture and negative pressure wound
   therapy in large torso degloving wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE infection; large torso defect; negative pressure wound therapy; trauma;
   wound; wound closure techniques; wound healing; vacuum-assisted closure
ID CLOSURE
AB Objective: To demonstrate the associated use of progressive tension sutures (PTS) with negative pressure wound therapy (NPWT) in large torso degloving wounds.
   Methods: This is a case report of two patients with large torso degloving wounds caused by trauma, both of whom were treated with combined PTS and NPWT. Statistics related to wound treatment responses are presented.
   Results: Initial wound area for Patient 1 was 2400cm(2) and 900cm(2) for Patient 2. Within 21 and 12 days, respectively, using the combined method, the following data were observed: wound reduction of 94% and 99%, respectively; a closing speed rate of 98cm(2)/day and 75cm(2)/day, respectively; and a closing percentage of 4.45% per day and 8.25% per day, respectively.
   Conclusion: The use of combined PTS and NPWT techniques may be useful in the treatment of traumatic degloving injuries, reducing the wound area and facilitating reconstruction.
C1 [Spencer Netto, Fernando A. C.; Becker, Mariana J.; Bertoldi, Ayessa; Shiroma, Henrique S.; Barreto, Hemanuelli] Univ Estadual Oeste Parana, Cascavel, Brazil.
   [Fontenelle Ribeiro Jr, Marcelo Augusto] Pontificia Univ Catolica Sao Paulo, Gen & Trauma Surg, Campus Sorocaba, Sorocaba, Brazil.
   [Fontenelle Ribeiro Jr, Marcelo Augusto] Fac Ciencias Med Sao Jose Campos, Surg, Sao Jose Dos Campos, Brazil.
   [Fontenelle Ribeiro Jr, Marcelo Augusto] Educ Comm Panamer Trauma Soc, Sao Paulo, Brazil.
   [Fontenelle Ribeiro Jr, Marcelo Augusto] Acad Master Surg Educ, Sao Paulo, Brazil.
C3 Universidade Estadual do Oeste do Parana; Pontificia Universidade
   Catolica de Sao Paulo
RP Becker, MJ (通讯作者)，Univ Estadual Oeste Parana, Cascavel, Brazil.
EM marianajbecker@gmail.com
RI SpencerNetto, Fernando/ODM-9751-2025; Fontenelle Ribeiro Junior, Marcelo
   Augusto/AFS-6590-2022
OI Fontenelle Ribeiro Junior, Marcelo Augusto/0000-0001-9826-4722
CR Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Ferreira Fernando, 2013, Rev. Col. Bras. Cir., V40, P85
   Gestring M., 2022, NEGATIVE PRESSURE WO
   Hop MJ, 2014, J WOUND CARE, V23, P144, DOI 10.12968/jowc.2014.23.3.144
   Lv ZM, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000015864
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Urbaniak RM, 2006, ANN PLAS SURG, V57, P573, DOI 10.1097/01.sap.0000237052.11796.63
   Veena PW, 2013, J WOUND CARE, V22, P562, DOI 10.12968/jowc.2013.22.10.562
NR 8
TC 0
Z9 1
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2022
VL 31
IS 4
BP 304
EP 308
DI 10.12968/jowc.2022.31.4.304
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0L6QX
UT WOS:000781598300004
PM 35404700
DA 2026-07-24
ER
PT J
AU Ahn, J
   Park, HY
   Shetty, AA
   Hwang, W
AF Ahn, Jiyong
   Park, Ho Youn
   Shetty, Asode Ananthram
   Hwang, Wonha
TI Use of injectable acellular dermal matrix combined with negative
   pressure wound therapy in open diabetic foot amputation
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE acellular dermal matrix; amputation; diabetes; diabetic foot ulcer;
   full-thickness skin graft; negative pressure wound therapy; skin graft;
   ulcer; wound; wound care; wound healing
ID ULCERS; RECONSTRUCTION; MANAGEMENT; CLOSURE; RISK
AB Objective: Skin grafts after negative pressure wound therapy (NPWT) and acellular dermal matrix (ADM) usage have both been useful for treating diabetic foot amputation. We hypothesised that injectable ADM combined with NPWT would be more useful than NPWT only for healing after amputation in patients with diabetic foot ulcers (DFUs). The aim of this study was to investigate the clinical outcomes of injectable ADM combined with NPWT in patients with DFU who have undergone amputation.
   Method: This retrospective study reviewed patients with infected DFUs who were administered NPWT. Patients were divided into two groups: Group 1 included patients who were treated with NPWT only, while Group 2 included patients who were treated with injectable ADM combined with NPWT. Clinical results including the number of NPWT dressing changes, wound healing duration, and full-thickness skin graft (FTSG) incident rate between the two groups were compared.
   Results: A total of 41 patients took part in the study (Group 1=20, Group 2=21). The mean number of NPWT dressing changes was significantly lower in Group 2 (8.71 +/- 3.77) than in Group 1 (13.90 +/- 5.62) (p=0.001). Mean wound healing period was shorter in Group 2 (3.17 +/- 1.36 weeks) than in Group 1 (5.47 +/- 1.68 weeks) (p=0.001). Finally, the rate of patients who underwent FTSG for complete wound closure was 85% in Group 1, whereas it was only 14.3% in Group 2.
   Conclusion: In this study, the use of injectable ADM combined with NPWT in patients with DFU who underwent amputation favoured complete wound healing, without the need to resort to the use of skin grafts.
C1 [Ahn, Jiyong; Park, Ho Youn; Hwang, Wonha] Catholic Univ Korea, Coll Med, Dept Orthopaed Surg, Seoul, South Korea.
   [Shetty, Asode Ananthram] Canterbury Christ Church Univ, Fac Hlth & Social Sci, Chatham, Kent, England.
C3 Catholic University of Korea; Canterbury Christ Church University
RP Ahn, J (通讯作者)，Catholic Univ Korea, Coll Med, Dept Orthopaed Surg, Seoul, South Korea.
EM ilmon@hanmail.net
RI Ahn, Jiyong/KDN-0493-2024
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   Rose JF, 2014, J VASC SURG, V59, P1657, DOI 10.1016/j.jvs.2013.12.046
   Roukis Thomas S, 2007, Clin Podiatr Med Surg, V24, P601, DOI 10.1016/j.cpm.2007.03.008
   Rupert P, 2016, J WOUND CARE, V25, pS17, DOI 10.12968/jowc.2016.25.Sup4.S17
   Santema TB, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011255.pub2
   Saraiya HA, 2013, ADV SKIN WOUND CARE, V26, P74, DOI 10.1097/01.ASW.0000426716.51702.29
   Sato T, 2016, J FOOT ANKLE SURG, V55, P628, DOI 10.1053/j.jfas.2015.05.005
   Svehlik J Jr, 2007, Acta Chir Plast, V49, P31
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NR 53
TC 5
Z9 5
U1 1
U2 14
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2022
VL 31
IS 4
BP 310
EP 320
DI 10.12968/jowc.2022.31.4.310
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0L6QX
UT WOS:000781598300005
PM 35404696
DA 2026-07-24
ER
PT J
AU Nangole, FW
   Agak, G
AF Nangole, Ferdinand Wanjala
   Agak, George
TI The effects of negative pressure wound therapy on wounds with
   cerebrospinal fluid leakages
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; NPWT; wounds with CSF leakage; wound;
   wound care; wound healing
ID VACUUM-ASSISTED CLOSURE; MECHANISM; HYPOXIA
AB Objective: Negative pressure wound therapy (NPWT) has been widely used for a variety of wounds with good outcomes. However, it is contraindicated in the management of wounds with cerebrospinal fluid (CSF) leakages. The reason is the fear of a sudden shift of CSF fluid as a result of suction leading to brain herniation or coning. There is a paucity of data to either support or negate such claims. We aimed to determine the effect of NPWT in the management of patients with wounds with CSF leakages.
   Method: This was a longitudinal prospective study of patients having wounds with CSF leakages managed with NPWT in our institute. Outcome measures evaluated were changes in the level of consciousness, Glasgow Coma Scale (GCS) score, length of hospital stay, mean effluent collected, time taken for the wounds to heal/close and complications related to NPWT.
   Results: A total of 12 patients with wounds that had CSF leakage were managed with NPWT over two years. Of the patients, nine had wounds in communication with the brain, with three patients having spinal cord wounds. The average effluent collected on the first day of applying NPWT was 510ml, and by the third day this had fallen to approximately 200ml. The mean time taken for wounds to close was 12.3 days. There was no evidence of herniation nor any other morbidities or mortalities reported in any of our patients.
   Conclusion: NPWT, as indicated in this series, had a beneficial effect in the management of wounds with CSF leakage. NPWT, once applied to the wound, caused a tamponade effect that resulted in stoppage of the leakage of the CSF and did not lead to suction of the fluid, as previously thought. The dressings ensured an airtight system, preventing communication between the wound and the external environment, thus reducing sepsis while awaiting definitive wound closure.
C1 [Nangole, Ferdinand Wanjala] Univ Nairobi, Dept Surg, POB 30197, Nairobi, Kenya.
   [Agak, George] Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Los Angeles, CA 90095 USA.
C3 University of Nairobi; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA
RP Nangole, FW (通讯作者)，Univ Nairobi, Dept Surg, POB 30197, Nairobi, Kenya.
EM nangole2212@gmail.com
RI Agak, George/AAN-2246-2021
CR Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 20
TC 2
Z9 2
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2022
VL 31
IS 4
BP 348
EP 351
DI 10.12968/jowc.2022.31.4.348
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0L6QX
UT WOS:000781598300009
PM 35404701
DA 2026-07-24
ER
PT J
AU MacKechnie, MC
   Flores, MJ
   Giordano, V
   Terry, MJ
   Garuz, M
   Lee, N
   Rojas, LGP
   MacKechnie, MA
   Bidolegui, F
   Brown, K
   Quintero, JE
   Ding, A
   Valenciano, CGS
   Neyra, HT
   Segovia, J
   Aguilar, D
   van Lieshout, EMM
   Verhofstad, MHJ
   Miclau, T
AF MacKechnie, Madeline C.
   Flores, Michael J.
   Giordano, Vincenzo
   Terry, Michael J.
   Garuz, Mario
   Lee, Nicolas
   Rojas, Luis G. Padilla
   MacKechnie, Michael A.
   Bidolegui, Fernando
   Brown, Kelsey
   Quintero, Jose Eduardo
   Ding, Anthony
   Valenciano, Carlos G. Sanchez
   Neyra, Horacio Tabares
   Segovia, Julio
   Aguilar, Dino
   van Lieshout, Esther M. M.
   Verhofstad, Michael H. J.
   Miclau, Theodore
TI Management of soft-tissue coverage of open tibia fractures in Latin
   America: Techniques, timing, and resources
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Flaps; Soft-tissue management; Wound coverage; Open tibia fractures;
   Latin America
ID TRAUMA-CARE; COST-EFFECTIVENESS; SMART COURSE; FLAP; RECONSTRUCTION;
   BURDEN; COUNTRIES; INJURIES; INCOME; FIX
AB Purpose: This study examined soft-tissue coverage techniques of open tibia fractures, described soft tissue treatment patterns across income groups, and determined resource accessibility and availability in Latin America.Methods: A 36-question survey was distributed to orthopaedic surgeons in Latin America through two networks: national orthopaedic societies and the Asociacion de Cirujanos Traumatologos de las Americas (ACTUAR). Demographic information was collected, and responses were stratified by income groups: high income countries (HICs) and middle-income countries (MICs). Results: The survey was completed by 469 orthopaedic surgeons, representing 19 countries in Latin America (2 HICs and 17 MICs). Most respondents were male (89%), completed residency training (96%), and were fellowship-trained (71%). Only 44% of the respondents had received soft-tissue training. Respondents (77%) reported a strong interest in attending a soft-tissue training course. Plastic surgeons were more commonly the primary providers for Gustilo Anderson (GA) Type IIIB injuries in HICs than in MICs (100% vs. 47%, p < 0.01) and plastic surgeons were more available ( < 24 h of patient presentation to the hospital) in HICs than MICs (63% vs. 26%, p = 0.05), demonstrating statistically significant differences. In addition, respondents in HICs performed free flaps more commonly than in MICs for proximal third (55% vs. 10%, p < 0.01), middle third (36% vs. 9%, p = 0.02), and distal third (55% vs. 10%, p < 0.01) lower extremity wounds. Negative Pressure Wound Therapy (NPWT or Wound VAC) was the only resource available to more than half of the respondents. Though not statistically significant, surgeons reported having more access to plastic surgeons at their institutions in HICs than MICs (91% vs. 62%, p = 0.12) and performed microsurgical flaps more commonly at their respective institutions (73% vs. 42%, p = 0.06).Conclusions: The study demonstrated that most orthopaedic surgeons in Latin America have received no soft-tissue training, HICs and MICs have differences in access to plastic surgeons and expectations for flap type and timing to definitive coverage, and most respondents had limited access to necessary soft-tissue surgical resources. Further investigation into differences in the clinical outcomes related to soft-tissue coverage methods and protocols can provide additional insight into the importance of timing and access to specialists.(c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
C1 [MacKechnie, Madeline C.; Flores, Michael J.; Terry, Michael J.; Lee, Nicolas; Brown, Kelsey; Ding, Anthony; Miclau, Theodore] Univ Calif San Francisco, Zuckerberg San Francisco Gen Hosp, Inst Global Orthopaed & Traumatol, Orthopaed Trauma Inst,Dept Orthopaed Surg, 2550 23rd St,Bldg 9,2nd Fl, San Francisco, CA 94110 USA.
   [Giordano, Vincenzo] Hosp Municipal Miguel Couto, Serv Ortopedia & Traumatol Prof Nova Monteiro, Ave Bartolomeu Mitre 1080, BR-22793260 Rio De Janeiro, Brazil.
   [Garuz, Mario] Hosp St Tomas, Calle 37 Este, Panama City, Panama.
   [Rojas, Luis G. Padilla] Puerta Hierro Hosp, Federac Mexicana Colegios Ortopedia & Traumatol A, Ave Empresarios 150, Zapopan 45116, Jalisco, Mexico.
   [MacKechnie, Michael A.] Cleveland Clin Martin Hlth, Dept Orthopaed Surg, Sports Med, 200 Hosp Ave, Stuart, FL 34994 USA.
   [Bidolegui, Fernando] Hosp Sirio Libanes, Serv Ortopedia & Traumatol, Campana 4658,C1419, Buenos Aires, DF, Argentina.
   [Quintero, Jose Eduardo] Fracturas & Fracturas, Carrera 12 Bis 9-22, Pereira Risaralda, Colombia.
   [Valenciano, Carlos G. Sanchez] Ctr Med Caracas, Ave Eraso,Plaza El Estanque Urb, Caracas, Venezuela.
   [Neyra, Horacio Tabares] Ctr Invest Longevidad Envejecimiento & Salud CITE, Soc Cubana Ortopedia & Traumatol, Calle G & 27, Vedado GP, Havana 10400, Cuba.
   [Segovia, Julio] Hosp Vivian Pellas, Cent Hosp, Inst Previs Social, Ave Sacramento & Dr Manuel Pena, Managua, Nicaragua.
   [Aguilar, Dino] Hosp Vivian Pellas, Ctr Ortopedia & Traumatol, POB 2261, Managua, Nicaragua.
   [van Lieshout, Esther M. M.; Verhofstad, Michael H. J.] Univ Med Ctr Rotterdam, Dept Surg, Trauma Res Unit, Erasmus MC, NL-3000 CA Rotterdam, Netherlands.
C3 University of California System; University of California San Francisco;
   Cleveland Clinic Foundation; University of Buenos Aires; University of
   Buenos Aires Hospital; Erasmus University Rotterdam; Erasmus MC
RP Miclau, T (通讯作者)，Univ Calif San Francisco, Zuckerberg San Francisco Gen Hosp, Inst Global Orthopaed & Traumatol, Orthopaed Trauma Inst,Dept Orthopaed Surg, 2550 23rd St,Bldg 9,2nd Fl, San Francisco, CA 94110 USA.
EM madeline.mackechnie@ucsf.edu; theodore.miclau@ucsf.edu
RI ; Giordano, Vincenzo/B-6285-2018
OI Verhofstad, Michael/0000-0001-8448-5903; Tabares Neyra, Horacio
   Inocencio/0000-0001-6599-4948; Flores, Michael/0000-0002-6842-3152;
   Brown, Kelsey/0000-0002-2811-6326; Garuz, Mario/0000-0002-7700-964X; 
CR Albright PD, 2020, J BONE JOINT SURG AM, V102, DOI 10.2106/JBJS.20.00292
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NR 46
TC 3
Z9 6
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD APR
PY 2022
VL 53
IS 4
BP 1422
EP 1429
DI 10.1016/j.injury.2022.01.027
EA MAR 2022
PG 8
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 0P5JE
UT WOS:000784257900015
PM 35101259
OA Bronze
DA 2026-07-24
ER
PT J
AU Hernandez, J
   Rosenthal, AA
AF Hernandez, Jennifer
   Rosenthal, Andrew A.
TI Hemipelvectomy as a Salvage Procedure in Massive Pelvic Trauma
SO AMERICAN SURGEON
LA English
DT Article
DE trauma; pelvic injury; mangled extremity severity score; critical care
AB "Pedestrian struck by train" represents one of the highest magnitude blunt force traumas. Despite the severity of injuries, these patients can have good outcomes. A 25-year-old male presented after being struck by a train. He had several injuries, including extensive complex pelvic fractures, right external iliac artery and vein laceration, and right femur and tibia fracture. He was taken to the operating room for damage control surgery and attempted revascularization of the right lower extremity. The extremity became ischemic and required above knee amputation followed by hip disarticulation and hemipelvectomy. His pelvic wounds were treated with negative pressure wound therapy and gradually closed. He was eventually discharged to a rehab facility for continued recovery. This case highlights the interventions that allowed a young man who was struck by a train to survive. He improved significantly since undergoing hemipelvectomy, indicating that severe pelvic injuries from high energy trauma may necessitate hemipelvectomy.
C1 [Hernandez, Jennifer; Rosenthal, Andrew A.] Mem Healthcare Syst, Dept Surg, 3501 Johnson St, Hollywood, FL 33021 USA.
RP Hernandez, J (通讯作者)，Mem Healthcare Syst, Dept Surg, 3501 Johnson St, Hollywood, FL 33021 USA.
EM jennifhernandez@mhs.net
OI Klein, Jennifer Hernandez/0000-0001-8836-4455
CR Burkhardt M, 2005, UNFALLCHIRURG, V108, P812, DOI 10.1007/s00113-005-0997-x
   Loja MN, 2017, J TRAUMA ACUTE CARE, V82, P518, DOI 10.1097/TA.0000000000001339
NR 2
TC 1
Z9 1
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JUL
PY 2022
VL 88
IS 7
BP 1568
EP 1569
AR 00031348221084939
DI 10.1177/00031348221084939
EA APR 2022
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2C7GT
UT WOS:000787629400001
PM 35465736
DA 2026-07-24
ER
PT J
AU Dadras, M
   Ufton, D
   Sogorski, A
   Wallner, C
   Wagner, JM
   Lehnhardt, M
   Harati, K
   Behr, B
AF Dadras, Mehran
   Ufton, Dominic
   Sogorski, Alexander
   Wallner, Christoph
   Wagner, Johannes M.
   Lehnhardt, Marcus
   Harati, Kamran
   Behr, Bjoern
TI Closed-Incision Negative-Pressure Wound Therapy after Resection of
   Soft-Tissue Tumors Reduces Wound Complications: Results of a Randomized
   Trial
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EXTREMITY; METAANALYSIS; MANAGEMENT;
   PREDICTORS; PERFUSION
AB Background: Wound healing after resection of large soft-tissue tumors is often impaired by large dead space and fluid collection. Recently, the authors were able to show an association of wound complications with worse oncologic outcome in soft-tissue sarcomas. The aim of the study was to examine the value of closed-incision negative pressure wound therapy on postoperative wound drainage and wound complications after soft-tissue tumor resection.
   Methods: Patients for whom resection is planned of a soft-tissue tumor larger than 10 cm in diameter of the extremities or the trunk were allocated randomly to one of two groups. After wound closure, patients in the study group received closed-incision negative-pressure wound therapy for a duration of 5 days, whereas those in the control group received regular dressings. The amount of drainage fluid, course of wound healing, length of hospital stay, and wound edge perfusion at postoperative day 5 measured by white-light infrared spectroscopy were compared.
   Results: Sixty patients could be included in the study with even distribution to both study arms, meeting the goal. The postoperative course of wound drainage volume was significantly lower in the study group, and hospital stay was significantly shorter, with 9.1 +/- 3.8 days versus 13.9 +/- 11.8 days. The occurrence of wound complications was significantly lower in the study group on time-to-event analysis (one versus six). Tissue spectroscopy revealed a significantly higher oxygen saturation increase in the wound edge for the study group versus the control group.
   Conclusion: Closed-incision negative-pressure wound therapy should be considered for patients undergoing resection of large soft-tissue tumors.
C1 [Dadras, Mehran; Ufton, Dominic; Sogorski, Alexander; Wallner, Christoph; Wagner, Johannes M.; Lehnhardt, Marcus; Harati, Kamran; Behr, Bjoern] BG Univ Hosp Bergmannsheil, Dept Plast Surg, Burkle Camp Pl 1, D-44789 Bochum, Germany.
C3 Ruhr University Bochum
RP Dadras, M (通讯作者)，BG Univ Hosp Bergmannsheil, Dept Plast Surg, Burkle Camp Pl 1, D-44789 Bochum, Germany.
EM mehran.dadras@rub.de
RI ; Behr, Björn/AAS-1877-2021; Harati, Kamran/AHD-3426-2022; Dadras,
   Mehran/R-2089-2019; Wallner, Christoph/JVO-4067-2024
OI , Dominic Ufton/0009-0008-2434-4883; 
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
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   Gomoll AH, 2006, J ORTHOP TRAUMA, V20, P705, DOI 10.1097/01.bot.0000211159.98239.d2
   Hasselmann J, 2020, ANN SURG, V271, P48, DOI 10.1097/SLA.0000000000003364
   Hyldig N, 2019, BJOG-INT J OBSTET GY, V126, P628, DOI 10.1111/1471-0528.15413
   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
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   Suh HSP, 2016, PLAST RECONSTR SURG, V138, P1333, DOI 10.1097/PRS.0000000000002765
   Suh H, 2016, ANN PLAS SURG, V76, P717, DOI 10.1097/SAP.0000000000000231
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NR 40
TC 8
Z9 8
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAY
PY 2022
VL 149
IS 5
DI 10.1097/PRS.0000000000009023
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 0V1QF
UT WOS:000788119300016
PM 35311753
DA 2026-07-24
ER
PT J
AU Steele, AW
   Miller, NF
   Wallace, SJ
   Hume, KM
   Sommers, CA
   Simmons, CJ
   Murphy, RX 
AF Steele, Andrew W.
   Miller, Nathan F.
   Wallace, Sean J.
   Hume, Keith M.
   Sommers, Catherine A.
   Simmons, Christopher J.
   Murphy, Robert X., Jr.
TI Hidradenitis Suppurativa: A Comparison of Institutional Experience and
   the Tracking Operations and Outcomes for Plastic Surgeons Registry
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT Plastic Surgery The Meeting / 88th Annual Meeting of the
   American-Society-of-Plastic-Surgeons (ASPS)
CY SEP 20-23, 2019
CL San Diego, CA
SP Amer Soc Plast Surg
ID NEGATIVE-PRESSURE DRESSINGS; SURGICAL-TREATMENT; RADICAL EXCISION;
   MANAGEMENT; CLOSURE; FLAP
AB Background: Hidradenitis suppurativa is a chronic inflammatory dermatologic condition occurring most commonly in areas with large numbers of apocrine sweat glands. Surgical excision and wound reconstruction are indicated for severe or refractory disease. This study aims to explore institutional reconstructive outcomes following hidradenitis suppurativa excision and compare these to the nationally recognized Tracking Operations and Outcomes for Plastic Surgeons (TOPS) database to determine best-practice guidelines. Methods: A retrospective chart review of all patients with surgically treated hidradenitis suppurativa from January of 2004 to January of 2016 was performed. Data on patient characteristics, reconstructive methods, and outcomes were collected. Outcomes for each reconstructive method were analyzed and associations between reconstruction and complications were determined. These results were compared to TOPS data. Results: A total of 382 operative sites for 101 individual patients were reviewed. Overall complication rates were 80, 68.3, and 59.6 percent for simple, intermediate, and complex closure, respectively; 68.3 percent for adjacent soft-tissue rearrangement; and 100 percent for split-thickness skin grafts and perforator flaps. Statistical significance was identified between superficial wound dehiscence and adjacent tissue rearrangement compared to intermediate and complex closure (p = 0.0132). TOPS data revealed similar wound breakdown rates for primary closure methods but much lower rates with negative-pressure wound therapy, split-thickness skin grafts, and muscle flaps. Conclusions: Primary closure techniques for hidradenitis suppurativa wound reconstruction possess high complication rates, whereas improved outcomes are observed with negative-pressure wound therapy, split-thickness skin grafts, and muscle flaps. The correlation in outcomes between our experience and that reported in the TOPS database provides a level of validation to this national database.
C1 [Steele, Andrew W.] Lehigh Valley Hlth Network, Div Plast Surg, 1200 South Cedar Crest Blvd, Allentown, PA 18103 USA.
   Amer Soc Plast Surg, San Diego, CA USA.
C3 Lehigh Valley Health Network
RP Steele, AW (通讯作者)，Lehigh Valley Hlth Network, Div Plast Surg, 1200 South Cedar Crest Blvd, Allentown, PA 18103 USA.
EM andrew.steele15@gmail.com
RI Murphy, Robert/HPC-2683-2023; /HRA-3825-2023
CR Alharbi Z, 2012, BMC DERMATOL, V12, DOI 10.1186/1471-5945-12-9
   Ather Shahzad, 2006, Int Wound J, V3, P159, DOI 10.1111/j.1742-481X.2006.00235.x
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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NR 25
TC 10
Z9 13
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAY
PY 2022
VL 149
IS 5
BP 1216
EP 1224
DI 10.1097/PRS.0000000000009024
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 0V1QF
UT WOS:000788119300054
PM 35311802
DA 2026-07-24
ER
PT J
AU Low, EZ
   Nugent, TS
   O'Sullivan, NJ
   Kavanagh, D
   Larkin, JO
   McCormick, PH
   Mehigan, BJ
   Kelly, ME
AF Low, Ernest Z.
   Nugent, Timothy S.
   O'Sullivan, Niall J.
   Kavanagh, Dara
   Larkin, John O.
   McCormick, Paul H.
   Mehigan, Brian J.
   Kelly, Michael E.
TI Application of PREVENA (Surgical Incision Protection System) in reducing
   surgical site infections following reversal of ileostomy or colostomy:
   the PRIC study protocol
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Reversal surgery; Ileostomy; Colostomy; Colorectal surgery; Negative
   pressure dressings; Surgical site infection; PREVENA therapy
ID PRESSURE WOUND THERAPY; CONVENTIONAL PRIMARY CLOSURE; ANTERIOR
   RESECTION; STOMA REVERSAL; METAANALYSIS; EXPERIENCE; MANAGEMENT; IMPACT
AB Aim There is a current lack of evidence in the literature to support the routine use of negative pressure wound therapy (NPWT) to reduce the risk of surgical site infections (SSI) in the setting of ileostomy or colostomy reversal. The aim of this study is to examine whether routine NPWT confers a lower rate of SSI than conventional dressings following reversal of ileostomy or colostomy. Methods The PRIC study is a randomized, controlled, open-label, multi-centre superiority trial to assess whether routine NPWT following wound closure confers a lower rate of SSI following reversal of ileostomy or colostomy when compared to conventional dressings. Participants will be consecutively identified and recruited. Eligible participants will be randomized in a 1:1 allocation ratio, to receive either the NPWT (PREVENA) dressings or conventional dressings which will be applied immediately upon completion of surgery. PREVENA dressings will remain applied for a duration of 7 days. Surgical wounds will then be examined on post-operative day seven as well as during follow-up appointments in OPD for any evidence of SSI. In the interim, public health nurses (PHN) will provide out-patient support services incorporating wound assessment and care as part of a routine basis. Study investigators will liaise with PHN to gather the relevant data in relation to the time to wound healing. Our primary endpoint is the incidence of SSI within 30 days of stoma reversal. Secondary endpoints include measuring time to wound healing, evaluating wound healing and aesthetics and assessing patient satisfaction. Conclusion The PRIC study will assess whether routine NPWT following wound closure is superior to conventional dressings in the reduction of SSI following reversal of ileostomy or colostomy and ascertain whether routine NPWT should be considered the new standard of care.
C1 [Low, Ernest Z.; Nugent, Timothy S.; Larkin, John O.; McCormick, Paul H.; Mehigan, Brian J.; Kelly, Michael E.] St James Hosp, Dept Colorectal Surg, Trinity Coll Dublin, Dublin, Ireland.
   [O'Sullivan, Niall J.; Kavanagh, Dara] Tallaght Univ Hosp, Dept Colorectal Surg, Dublin, Ireland.
C3 Trinity College Dublin
RP Low, EZ (通讯作者)，St James Hosp, Dept Colorectal Surg, Trinity Coll Dublin, Dublin, Ireland.
EM lowe@tcd.ie
RI Kelly, Michael E/AAF-1917-2021
OI Kelly, Michael E/0000-0002-0757-6411
FU IReL Consortium
FX Open Access funding provided by the IReL Consortium.
CR Acelity.com, 2020, PREVENA TRADE THER
   Alexander JW, 2011, ANN SURG, V253, P1082, DOI 10.1097/SLA.0b013e31821175f8
   [Anonymous], 2018, Protocol for Surgical Site Infection Surveillance with a Focus on Settings with Limited Resources
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   Blackham AU, 2013, AM J SURG, V205, P647, DOI 10.1016/j.amjsurg.2012.06.007
   Carrano FM, 2021, BJS OPEN, V5, DOI 10.1093/bjsopen/zrab116
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   Condé-Green A, 2013, ANN PLAS SURG, V71, P394, DOI 10.1097/SAP.0b013e31824c9073
   Gheorghe A, 2015, VALUE HEALTH, V18, P1126, DOI 10.1016/j.jval.2015.08.004
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   Taylor C, 2013, J WOUND OSTOMY CONT, V40, P415, DOI 10.1097/WON.0b013e318296b5a4
   Taylor C, 2011, EUR J ONCOL NURS, V15, P59, DOI 10.1016/j.ejon.2010.06.002
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   Wierdak M, 2021, TECH COLOPROCTOL, V25, P185, DOI 10.1007/s10151-020-02372-w
NR 29
TC 5
Z9 8
U1 2
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD MAY
PY 2022
VL 37
IS 5
BP 1215
EP 1221
DI 10.1007/s00384-022-04153-3
EA APR 2022
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 0Z8MH
UT WOS:000789000700002
PM 35487978
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Norman, G
   Shi, CH
   Goh, EL
   Murphy, EMA
   Reid, A
   Chiverton, L
   Stankiewicz, M
   Dumville, JC
AF Norman, Gill
   Shi, Chunhu
   Goh, En Lin
   Murphy, Elizabeth M. A.
   Reid, Adam
   Chiverton, Laura
   Stankiewicz, Monica
   Dumville, Jo C.
TI Negative pressure wound therapy for surgical wounds healing by primary
   closure
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Bandages; Blister [epidemiology]; Hematoma [epidemiology];
   Negative-Pressure Wound Therapy [economics] [instrumentation] [*methods]
   [mortality]; Orthopedic Procedures; Quality Adjusted Life Years;
   Randomized Controlled Trials as Topic; Reoperation [statistics &
   numerical data]; Seroma [epidemiology]; *Skin Transplantation; Surgical
   Procedures, Operative [mortality]; Surgical Wound Dehiscence
   [epidemiology] [*prevention & control]; Surgical Wound Infection
   [epidemiology] [*prevention & control]; *Wound Healing; Wounds and
   Injuries [surgery]; Humans
ID VACUUM-ASSISTED-CLOSURE; RANDOMIZED CONTROLLED-TRIAL; SEVERE OPEN
   FRACTURES; SITE INFECTION; LOWER-LIMB; COST-EFFECTIVENESS;
   CLINICAL-EFFICACY; TISSUE EXPANSION; SUCTION DRAINAGE; CESAREAN-SECTION
AB Background
   Indications for the use of negative pressure wound therapy (NPWT) are broad and include prophylaxis for surgical site infections (SSIs). Existing evidence for the effectiveness of NPWT on postoperative wounds healing by primary closure remains uncertain.
   Objectives
   To assess the effects of NPWT for preventing SSI in wounds healing through primary closure, and to assess the cost-effectiveness of NPWT in wounds healing through primary closure.
   Search methods
   In January 2021, we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE (including In-Process & Other Non-Indexed Citations); Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries and references of included studies, systematic reviews and health technology reports. There were no restrictions on language, publication date or study setting.
   Selection criteria
   We included trials if they allocated participants to treatment randomly and compared NPWT with any other type of wound dressing, or compared one type of NPWT with another.
   Data collection and analysis
   At least two review authors independently assessed trials using predetermined inclusion criteria. We carried out data extraction, assessment using the Cochrane risk of bias tool, and quality assessment according to Grading of Recommendations, Assessment, Development and Evaluations methodology. Our primary outcomes were SSI, mortality, and wound dehiscence.
   Main results
   In this fourth update, we added 18 new randomised controlled trials (RCTs) and one new economic study, resulting in a total of 62 RCTs (13,340 included participants) and six economic studies. Studies evaluated NPWT in a wide range of surgeries, including orthopaedic, obstetric, vascular and general procedures. All studies compared NPWT with standard dressings. Most studies had unclear or high risk of bias for at least one key domain.
   Primary outcomes
   Eleven studies (6384 participants) which reported mortality were pooled. There is low-certainty evidence showing there may be a reduced risk of death after surgery for people treated with NPWT (0.84%) compared with standard dressings (1.17%) but there is uncertainty around this as confidence intervals include risk of benefits and harm; risk ratio (RR) 0.78 (95% CI 0.47 to 1.30;I-2 = 0%). Fifty-four studies reported SSI; 44 studies (11,403 participants) were pooled. There is moderate-certainty evidence that NPWT probably results in fewer SSIs (8.7% of participants) than treatment with standard dressings (11.75%) after surgery; RR 0.73 (95% CI 0.63 to 0.85;I-2 = 29%). Thirty studies reported wound dehiscence; 23 studies (8724 participants) were pooled. There is moderate-certainty evidence that there is probably little or no difference in dehiscence between people treated with NPWT (6.62%) and those treated with standard dressing (6.97%), although there is imprecision around the estimate that includes risk of benefit and harms; RR 0.97 (95% CI 0.82 to 1.16;I-2 = 4%). Evidence was downgraded for imprecision, risk of bias, or a combination of these.
   Secondary outcomes
   There is low-certainty evidence for the outcomes of reoperation and seroma; in each case, confidence intervals included both benefit and harm. There may be a reduced risk of reoperation favouring the standard dressing arm, but this was imprecise: RR 1.13 (95% CI 0.91 to 1.41;I-2 = 2%; 18 trials; 6272 participants). There may be a reduced risk of seroma for people treated with NPWT but this is imprecise: the RR was 0.82 (95% CI 0.65 to 1.05;I-2 = 0%; 15 trials; 5436 participants). For skin blisters, there is low-certainty evidence that people treated with NPWT may be more likely to develop skin blisters compared with those treated with standard dressing (RR 3.55; 95% CI 1.43 to 8.77; I-2 = 74%; 11 trials; 5015 participants). The effect of NPWT on haematoma is uncertain (RR 0.79; 95 % CI 0.48 to 1.30;I-2 = 0%; 17 trials; 5909 participants; very low-certainty evidence). There is low-certainty evidence of little to no difference in reported pain between groups. Pain was measured in different ways and most studies could not be pooled; this GRADE assessment is based on all fourteen trials reporting pain; the pooled RR for the proportion of participants who experienced pain was 1.52 (95% CI 0.20,11.31; I-2 = 34%; two studies; 632 participants).
   Cost-effectiveness
   Six economic studies, based wholly or partially on trials in our review, assessed the cost-effectiveness of NPWT compared with standard care. They considered NPWT in five indications: caesarean sections in obese women; surgery for lower limb fracture; knee/hip arthroplasty; coronary artery bypass grafts; and vascular surgery with inguinal incisions. They calculated quality-adjusted life-years or an equivalent, and produced estimates of the treatments' relative cost-effectiveness. The reporting quality was good but the evidence certainty varied from moderate to very low. There is moderate-certainty evidence that NPWT in surgery for lower limb fracture was not cost-effective at any threshold of willingness-to-pay and that NPWT is probably cost-effective in obese women undergoing caesarean section. Other studies found low or very low-certainty evidence indicating that NPWT may be cost-effective for the indications assessed.
   Authors' conclusions
   People with primary closure of their surgical wound and treated prophylactically with NPWT following surgery probably experience fewer SSIs than people treated with standard dressings but there is probably no difference in wound dehiscence (moderate-certainty evidence). There may be a reduced risk of death after surgery for people treated with NPWT compared with standard dressings but there is uncertainty around this as confidence intervals include risk of benefit and harm (low-certainty evidence). People treated with NPWT may experience more instances of skin blistering compared with standard dressing treatment (low-certainty evidence). There are no clear differences in other secondary outcomes where most evidence is low or very low-certainty. Assessments of cost-effectiveness of NPWT produced differing results in different indications. There is a large number of ongoing studies, the results of which may change the findings of this review. Decisions about use of NPWT should take into account surgical indication and setting and consider evidence for all outcomes.
C1 [Norman, Gill; Shi, Chunhu; Dumville, Jo C.] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
   [Goh, En Lin] Nuffield Dept Orthopaed Rheumatol & Musculoskelet, 0Xford Trauma, Oxford, England.
   [Murphy, Elizabeth M. A.] Manchester Fdn NHS Trust, Ward 64, St Marys Hosp, Manchester, Lancs, England.
   [Reid, Adam] Fac Biol Med & Hlth, Sch Biol Sci, Manchester, Lancs, England.
   [Chiverton, Laura] Great Ormond St Hosp Sick Children, NIHR Clin Res Facil, London, England.
   [Stankiewicz, Monica] Community & Oral Hlth Directorate, Chermside Community Hlth Ctr, Brisbane, Qld, Australia.
C3 University of Manchester; University of Manchester; University of
   Manchester; University of London; University College London; Great
   Ormond Street Hospital for Children NHS Foundation Trust
RP Norman, G (通讯作者)，Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
EM gill.norman@manchester.ac.uk
RI ; Norman, Gill/O-7029-2014; Goh, En/I-7020-2019; Reid, Adam/G-4460-2014;
   Dumville, Jo/O-7867-2014
OI Shi, Chunhu/0000-0003-0151-0451; Stankiewicz,
   Monica/0000-0003-3970-071X; Reid, Adam/0000-0003-1752-3302; Dumville,
   Jo/0000-0002-6546-3685
FU Division of Nursing, Midwifery and Social Work, School of Health
   Sciences, Faculty of Biology, Medicine and Health, University of
   Manchester, UK; Royal Brisbane and Women's Hospital, Australia; GriGith
   University, Australia; NIHR Manchester Biomedical Research Centre, UK;
   NIHR Manchester Biomedical Research Centre; National Institute for
   Health Research Applied Research Collaboration Greater Manchester, UK;
   National Institute for Health Research Applied Research Collaboration
   Greater Manchester; National Institute for Health Research, UK; National
   Institute for Health Research
FX Internal sourcesDivision of Nursing, Midwifery and Social Work, School
   of Health Sciences, Faculty of Biology, Medicine and Health, University
   of Manchester, UKSupport from Cochrane Wounds editorial baseRoyal
   Brisbane and Women's Hospital, AustraliaTime to conduct reviewGriGith
   University, AustraliaTime to conduct reviewExternal sourcesNIHR
   Manchester Biomedical Research Centre, UKThis review was co-funded by
   the NIHR Manchester Biomedical Research Centre. The views expressed in
   this publication are those of the author(s) and not necessarily those of
   the NHS, the National Institute for Health Research or the Department of
   Health and Social Care.National Institute for Health Research Applied
   Research Collaboration Greater Manchester, UKSeveral of the authors are
   partially funded by the National Institute for Health Research Applied
   Research Collaboration Greater Manchester. The views expressed in this
   publication are those of the authors and not necessarily those of the
   National Institute for Health. Research or the Department of Health and
   Social Care.National Institute for Health Research, UKThis project was
   supported by the National Institute for Health Research, via Cochrane
   Infrastructure funding to Cochrane Wounds. The views expressed are those
   of the authors and not necessarily those of the NIHR or the Department
   of Health and Social Care.
CR Abesamis GM, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002141
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NR 266
TC 110
Z9 140
U1 3
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2022
IS 4
AR CD009261
DI 10.1002/14651858.CD009261.pub7
PG 274
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0X9FO
UT WOS:000790005300020
PM 35471497
OA Green Published, Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Nguyen, KA
   Taylor, GA
   Webster, TK
   Jenkins, RA
   Houston, NS
   Kahler, DL
   Gassman, AA
   Jones, CM
AF Nguyen, Kaitlin A.
   Taylor, George A.
   Webster, Theresa K.
   Jenkins, Rachel A.
   Houston, Nicklaus S.
   Kahler, Dylan L.
   Gassman, Andrew A.
   Jones, Christine M.
TI Incisional Negative Pressure Wound Therapy Is Protective Against
   Postoperative Cardiothoracic Wound Infection
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE closed incision negative pressure therapy; ciNPT; wound healing; wound
   infection; sternal wound; Prevena
ID MANAGEMENT; RISK; STATINS; IMPACT
AB Background Sternal wound infections are a rare but life-threatening complication of cardiothoracic surgery. Prior literature has supported the use of negative pressure wound therapy to decrease sternal wound infections and promote healing. This study sought to determine whether closed incision negative pressure therapy reduced wound infection and improved outcomes in cardiothoracic surgery. Methods A retrospective cohort study was performed including all adult patients who underwent nontraumatic cardiothoracic surgery at a single institution between 2016 and 2018 (n = 1199). Patient characteristics, clinical variables, and surgical outcomes were compared between those who did and did not receive incisional negative pressure wound therapy intraoperatively. Multivariable logistic regression analysis determined factors predictive or protective of the development of complications. Results Incisional negative pressure wound therapy was used in 58.9% of patients. Patients who received this therapy were older with statistically higher rates of hyperlipidemia, statin, and antihypertensive use. The use of negative pressure wound therapy was found to significantly reduce rates of both wound infection (3.0% vs 6.3%, P = 0.01) and readmission for wound infection (0.7% vs 2.6%, P = 0.01). After controlling for confounding variables, negative pressure wound therapy was found to be a protective factor of surgical wound infection (odds ratio, 0.497; 95% confidence interval, 0.262-0.945). Conclusions In the largest population studied to date, this study supported the expanded use of negative pressure therapy on sternal wound incisions to decrease infection rates.
C1 [Nguyen, Kaitlin A.; Taylor, George A.; Webster, Theresa K.; Jenkins, Rachel A.; Houston, Nicklaus S.; Kahler, Dylan L.; Jones, Christine M.] Temple Univ Hosp & Med Sch, Dept Surg, 3401 N Broad St, Philadelphia, PA 19140 USA.
   [Gassman, Andrew A.] PRMA Plast Surg Ctr Adv Reconstruct, San Antonio, TX USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University
RP Nguyen, KA; Jones, CM (通讯作者)，Temple Univ Hosp & Med Sch, Dept Surg, 3401 N Broad St, Philadelphia, PA 19140 USA.
EM kaitlin.nguyen@temple.edu; christine.jones@tuhs.temple.edu
RI ; Taylor, George/GLV-2344-2022
OI Jones, Christine/0000-0002-6333-8039; Nguyen,
   Kaitlin/0000-0002-9563-0106; 
CR [Anonymous], PREVENA INCISION MAN
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NR 19
TC 6
Z9 7
U1 2
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2022
VL 88
IS 3
SU 3
BP S197
EP S200
DI 10.1097/SAP.0000000000003196
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 0Z3SX
UT WOS:000791002000013
PM 35513319
DA 2026-07-24
ER
PT J
AU Juntermanns, B
   Kröger, K
   Waldhausen, P
   Gäbel, G
AF Juntermanns, Benjamin
   Kroeger, Knut
   Waldhausen, Peter
   Gaebel, Gabor
TI Venous ulcus cruris-Surgical treatment
SO HAUTARZT
LA German
DT Article
DE Ulcus cruris; Compression therapy; Negative pressure wound therapy;
   Ulcer shaving; Skin transplantation
ID LEG ULCERS; COMPRESSION; THERAPY; SURGERY
AB Venous ulcus cruris is usually a chronic disease and an extreme burden for patients and their families. An analysis based on a random statutory health insurance sample of the AOK Hessen/KV Hessen estimated the number of affected people to be 400,000 in Germany. A venous ulcus cruris is always caused by an underlying chronic venous insufficiency (CVI). A spontaneous healing of this chronic disease without treatment is not to be expected. The conservative treatment includes an adequate compression treatment and exudate management. Surgical treatment is based on three pillars: an open surgical or endovenous approach to resolve the pathological venous reflux, uIcer surgery and in rare cases the various procedures of fascia surgery as well as defect coverage by a combination of negative pressure wound therapy and skin transplantation.
C1 [Juntermanns, Benjamin; Waldhausen, Peter] MVZ Gefassmed Krefeld, Luisenpl 6-8, D-47799 Krefeld, Germany.
   [Juntermanns, Benjamin; Kroeger, Knut; Waldhausen, Peter; Gaebel, Gabor] HELIOS Klinikum Krefeld, Klin Gefassmed, Krefeld, Germany.
C3 Helios Kliniken
RP Juntermanns, B (通讯作者)，MVZ Gefassmed Krefeld, Luisenpl 6-8, D-47799 Krefeld, Germany.
EM benjamin.juntermanns@helios-gesundheit.de
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NR 48
TC 2
Z9 2
U1 1
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0017-8470
EI 1432-1173
J9 HAUTARZT
JI Hautarzt
PD JUN
PY 2022
VL 73
IS 6
SI SI
BP 491
EP 500
DI 10.1007/s00105-022-05006-4
EA MAY 2022
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1S3XR
UT WOS:000794107100001
PM 35551422
DA 2026-07-24
ER
PT J
AU Angarita, AM
   Jayakumaran, J
   Di Mascio, D
   Berghella, V
AF Angarita, Ana M.
   Jayakumaran, Jenani
   Di Mascio, Daniele
   Berghella, Vincenzo
TI Prophylactic negative pressure wound therapy on wound complications
   after cesarean delivery in women with obesity: a meta-analysis of
   randomized controlled trials
SO AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
LA English
DT Review
DE cesarean delivery; negative pressure wound therapy; obesity; surgical
   site infection; wound; wound complications
ID SURGICAL-SITE INFECTION; RISK; SECTION
AB OBJECTIVE: This systematic review and meta-analysis of randomized controlled trials aimed to assess whether negative pressure wound therapy affects the rate of wound complications when applied to women with obesity after cesarean delivery compared with standard postoperative dressings.
   DATA SOURCES: This research used PubMed, Scopus, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials as electronic databases, from the inception of each database to January 2021, with randomized controlled trial as the publication type. There was no restriction applied for language or geographic location.
   STUDY ELIGIBILITY CRITERIA: The selection criteria included only randomized controlled trials comparing the effect of negative pressure wound therapy with that of standard dressings on wound complications in women with obesity undergoing cesarean delivery.
   METHODS: The primary outcome was a wound complication composite outcome (wound infection, separation or dehiscence, hematoma, seroma, or readmission secondary to a wound concern). The wound complication composite was analyzed by counting events once per patient. The summary measures were reported as relative risk or as mean difference with 95% confidence intervals using the random-effects model of DerSimonian and Laird. An I squared (Higgins I-2) value of >0% was used to identify heterogeneity.
   RESULTS: Overall, 11 randomized controlled trials, which included 5746 participants with obesity undergoing cesarean delivery, were included. Of those participants, 2869 (49.9%) were randomized to the intervention group (negative pressure wound therapy), and 2877 (50.1%) were randomized to the control group (standard dressing). Prophylactic negative pressure wound therapy was not associated with a significant change in the rate of wound complications (relative risk, 1.00; 95% confidence interval, 0.81-1.23) compared with standard postoperative dressings. However, the use of negative pressure wound therapy decreased the rate of wound infections (relative risk, 0.79; 95% confidence interval, 0.66-0.96) and increased the frequency of skin reactions (relative risk, 4.59; 95% confidence interval, 1.29-16.38). Negative pressure wound therapy did not result in a significant difference in the rate of dehiscence, hematoma, seroma, readmission, reoperation, and antibiotic use for wound infection.
   CONCLUSION: Compared with standard postoperative incision dressings, negative pressure wound therapy did not affect the rate of wound complications but decreased the frequency of wound infections when applied to women with obesity after cesarean delivery. However, results should be interpreted with caution, as wound infection outcome includes different defi-nitions per the individual trials.
   CONDENSATION: Prophylactic negative pressure wound therapy has no effect on overall wound complications in women with obesity after cesarean delivery compared with standard dressings.
C1 [Angarita, Ana M.; Jayakumaran, Jenani; Berghella, Vincenzo] Thomas Jefferson Univ, Div Maternal Fetal Med, Dept Obstet & Gynecol, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA.
   [Di Mascio, Daniele] Sapienza Univ Rome, Dept Maternal & Child Hlth & Urol Sci, Rome, Italy.
C3 Thomas Jefferson University; Sapienza University Rome
RP Berghella, V (通讯作者)，Thomas Jefferson Univ, Div Maternal Fetal Med, Dept Obstet & Gynecol, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA.
EM vincenzo.berghella@jefferson.edu
RI Di Mascio, Daniele/AAK-2534-2020; Berghella, Vincenzo/K-8634-2018
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NR 34
TC 9
Z9 10
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2589-9333
J9 AM J OBST GYNEC MFM
JI Amer. J. Obstet. Gynecol. MFM
PD MAY
PY 2022
VL 4
IS 3
AR 100617
DI 10.1016/j.ajogmf.2022.100617
EA APR 2022
PG 13
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 1F0KB
UT WOS:000794865000032
PM 35283349
DA 2026-07-24
ER
PT J
AU Curchod, P
   Clerc, D
   Jurt, J
   Hubner, M
   Hahnloser, D
   Demartines, N
   Grass, F
AF Curchod, P.
   Clerc, D.
   Jurt, J.
   Hubner, M.
   Hahnloser, D.
   Demartines, N.
   Grass, F.
TI Closed-wound negative pressure therapy dressing after loop ostomy
   closure: a retrospective comparative study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PRIMARY SKIN CLOSURE; STOMA REVERSAL; INFECTIONS
AB Closed-wound negative pressure wound therapy (NPWT) dressings were recently introduced with the purpose to reduce incisional surgical site infections (iSSI) in high-risk wounds. The aim of this study was to compare iSSI rates in patients after ostomy closure with and without additional application of a closed-wound NPWT dressing. Single-center retrospective analysis of consecutive patients undergoing ileo- or colostomy closure over an 8-year period (January 2013-January 2021). Intradermal non-purse string technique with absorbable sutures were used in all patients. Since November 2018, all patients (study group) received a NPWT device for a maximum of 5 days postoperatively (PICO, SMITH AND NEPHEW). Primary outcome was iSSI rate within 30 days of surgery. SSI was defined in accordance with the Center of Disease Control (CDC) classification and included superficial and deep incisional SSI. Data was retrieved from the institutional enhanced recovery after surgery (ERAS) database, with standardized complication assessment by trained abstractors. In total, 85 patients (25%) in the study group were comparable with 252 (75%) patients in the control group regarding demographics (age, gender, body mass index, ASA score), ostomy type and anastomotic technique (all p > 0.05), but not wound contamination class (class III: 5% vs 0%, p < 0.001). Median time to NPWT removal was 4 (IQR 3-5) days. Incisional SSI were observed in 4 patients (4.7%) in the study group and in 27 patients (10.7%) in the control group (p = 0.097). These preliminary results suggest a potential benefit of systematic application of the NPWT device after loop ostomy closure. A randomized controlled study is needed.
C1 [Curchod, P.; Clerc, D.; Jurt, J.; Hubner, M.; Hahnloser, D.; Demartines, N.; Grass, F.] Univ Lausanne UNIL, Lausanne Univ Hosp CHUV, Dept Visceral Surg, 26 Rue Bugnon, CH-1010 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Hubner, M (通讯作者)，Univ Lausanne UNIL, Lausanne Univ Hosp CHUV, Dept Visceral Surg, 26 Rue Bugnon, CH-1010 Lausanne, Switzerland.
EM hubner@chuv.ch
RI Clerc, Daniel/HMP-2088-2023; hübner, martin/J-6715-2017; Hahnloser,
   Dieter/J-6714-2017
OI Clerc, Daniel/0000-0002-9285-3312; hübner, martin/0000-0002-4521-8279; 
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NR 16
TC 7
Z9 7
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 12
PY 2022
VL 12
IS 1
AR 7790
DI 10.1038/s41598-022-11856-8
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1F4TU
UT WOS:000795163100062
PM 35550575
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Deng, XX
   Gould, M
   Ali, MA
AF Deng, Xiaoxuan
   Gould, Maree
   Ali, M. Azam
TI A review of current advancements for wound healing: Biomaterial
   applications and medical devices
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Review
DE biomaterial; biomedical device; chronic wound; wound healing
ID DRESSING IN-VITRO; SILK FIBROIN; ELECTROSPUN NANOFIBERS; SURGICAL
   SUTURES; GROWTH-FACTORS; STEM-CELLS; ANTIBACTERIAL ACTIVITY;
   EXTRACELLULAR-MATRIX; SUSTAINED-RELEASE; COATED SUTURES
AB Wound healing is a complex process that is critical in restoring the skin's barrier function. This process can be interrupted by numerous diseases resulting in chronic wounds that represent a major medical burden. Such wounds fail to follow the stages of healing and are often complicated by a pro-inflammatory milieu attributed to increased proteinases, hypoxia, and bacterial accumulation. The comprehensive treatment of chronic wounds is still regarded as a significant unmet medical need due to the complex symptoms caused by the metabolic disorder of the wound microenvironment. As a result, several advanced medical devices, such as wound dressings, wearable wound monitors, negative pressure wound therapy devices, and surgical sutures, have been developed to correct the chronic wound environment and achieve skin tissue regeneration. Most medical devices encompass a wide range of products containing natural (e.g., chitosan, keratin, casein, collagen, hyaluronic acid, alginate, and silk fibroin) and synthetic (e.g., polyvinyl alcohol, polyethylene glycol, poly[lactic-co-glycolic acid], polycaprolactone, polylactic acid) polymers, as well as bioactive molecules (e.g., chemical drugs, silver, growth factors, stem cells, and plant compounds). This review addresses these medical devices with a focus on biomaterials and applications, aiming to deliver a critical theoretical reference for further research on chronic wound healing.
C1 [Deng, Xiaoxuan; Gould, Maree; Ali, M. Azam] Univ Otago, Fac Dent, Ctr Bioengn & Nanomed Dunedin, Dept Oral Rehabil, Dunedin, New Zealand.
C3 University of Otago
RP Ali, MA (通讯作者)，Univ Otago, Polymer & Biomat Sci & Engn, Dunedin, New Zealand.
EM azam.ali@otago.ac.nz
RI Ali, Azam/PKR-6193-2026; Deng, Xiaoxuan/GQR-1757-2022
OI Deng, Xiaoxuan/0000-0002-8152-875X
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NR 287
TC 249
Z9 284
U1 14
U2 196
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD NOV
PY 2022
VL 110
IS 11
BP 2542
EP 2573
DI 10.1002/jbm.b.35086
EA MAY 2022
PG 32
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 4N7DJ
UT WOS:000796484200001
PM 35579269
OA Green Submitted, hybrid
HC Y
HP N
DA 2026-07-24
ER
PT J
AU Costa, ML
   Achten, J
   Parsons, NR
AF Costa, M. L.
   Achten, J.
   Parsons, N. R.
CA WOLLF collaborators
TI Five-year outcomes for patients sustaining severe fractures of the lower
   limb MID-TERM RESULTS FROM THE WOUND MANAGEMENT FOR OPEN LOWER LIMB
   FRACTURE (WOLLF) TRIAL
SO BONE & JOINT JOURNAL
LA English
DT Article
ID ADULTS; DISABILITY; INFECTION; THERAPY; EUROQOL
AB Aims
   The aim of this study was to report the outcomes of patients with severe open fractures of the lower limb in the five years after they took part in the Wound management for Open Lower Limb Fracture (WOLLF) trial.
   Methods
   The WOLLF trial compared standard dressings to negative pressure wound therapy (NPWT) applied at the end of the first surgical wound debridement, and patients were followed-up for 12 months. At 12 months, 170 of the original 460 participants agreed to take part in this medium-term follow-up study. Patients reported their Disability Rating Index (DRI) (0 to 100, where 100 is total disability) and health-related quality of life (HRQoL) using the EuroQol five-dimension three-level health questionnaire (EQ-5D-3L) annually by self-reported questionnaire. Further surgical interventions related to the open fracture were also recorded.
   Results
   There was no evidence of a difference in patient-reported disability, HROoL, or the need for further surgery between patients treated with NPWT versus standard dressings at five years. Considering the combined results for all participants, there was a small but statistically significant change in DRI scores over time (1.6 units per year; p = 0.005), but no evidence that EQ-5D-3L scores changed significantly during years two to five (p = 0.551).
   Conclusion
   This study shows that the high levels of disability and reduced HRQoL reported by patients 12 months after severe open fractures of the lower limb persist in the medium term, with little evidence of improvement between years two and five.
C1 [Costa, M. L.] Univ Oxford, Orthopaed Trauma Surg, Oxford, England.
   [Achten, J.] Univ Oxford, Oxford Trauma & Emergency Care, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
   [Parsons, N. R.] Univ Warwick, Warwick Med Sch, Clin Trials Unit, Coventry, W Midlands, England.
C3 University of Oxford; University of Oxford; University of Warwick
RP Costa, ML (通讯作者)，Univ Oxford, Orthopaed Trauma Surg, Oxford, England.
EM matthew.costa@ndorms.ox.ac.uk
RI ; Parsons, Nick/AAA-8713-2019; Achten, Juul/KUD-8515-2024
OI Costa, Matthew/0000-0003-3644-1388; Parsons, Nick/0000-0001-9975-888X;
   Achten, Juul/0000-0002-8857-5743
FU UK National Institute for Health Research (NIHR) Health Technology
   Assessment (HTA) programme [10/57/20]; NIHR HTA programme [HTA
   10/57/20]; NIHR Oxford Biomedical Research Centre; National Institutes
   of Health Research (NIHR) [HTA/10/57/20] Funding Source: National
   Institutes of Health Research (NIHR)
FX The authors disclose receipt of the following financial or material
   support for the research, authorship, and/or publication of this
   article: funding from the UK National Institute for Health Research
   (NIHR) Health Technology Assessment (HTA) programme (reference 10/57/20)
   . The original WOLLF trial was funded by the NIHR HTA programme (HTA
   10/57/20) and this five-year follow-up was supported by the NIHR Oxford
   Biomedical Research Centre. The funder has not been involved in the
   design and conduct of the study; collection, management, analysis, and
   interpretation of the data, the preparation, review, or approval of the
   manuscript, nor in the decision to submit the manuscript for
   publication. The views expressed are those of the authors and not
   necessarily those of the NHS, the NIHR or the Department of Health.
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NR 16
TC 9
Z9 14
U1 0
U2 2
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD MAY
PY 2022
VL 104B
IS 5
BP 633
EP 639
DI 10.1302/0301-620X.104B5.BJJ-2021-1568.R2
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 1H6ZV
UT WOS:000796690300009
PM 35491582
DA 2026-07-24
ER
PT J
AU Sogorski, A
   Becker, A
   Dadras, M
   Wallner, C
   Wagner, JM
   Glinski, M
   Lehnhardt, M
   Behr, B
AF Sogorski, Alexander
   Becker, Amira
   Dadras, Mehran
   Wallner, Chtistoph
   Wagner, Johannes Maximillian
   Glinski, Maxi, V
   Lehnhardt, Marcus
   Behr, Bjoern
TI Superior Enhancement of Cutaneous Microcirculation Due to "Cyclic"
   Application of a Negative Pressure Wound Therapy Device in Humans -
   Local and Remote Effects
SO FRONTIERS IN SURGERY
LA English
DT Article
DE Negative Pressure Wound Therapy (NPWT); cutaneous microcirculation;
   wound healing; remote conditioning; Vacuum-assisted closure (VAC)
ID VACUUM-ASSISTED CLOSURE; BLOOD-FLOW; STATE
AB ObjectivesDespite a common utilization of "Negative Pressure Wound Therapy" (NPWT) Devices in a wide range of specialties, some of the basic mechanisms of action of the techniques are still on debate. Conflicting results from prior studies demonstrate our lack of understanding how wound-bed perfusion or cutaneous microcirculation is affected by NPWT. MethodsWe conducted a prospective randomized study which included 45 healthy subjects to further investigate the acute effects of NPWT on cutaneous microcirculation underneath the applied dressing. Three modes of application, namely, continuous, intermittent, cyclic, were tested. Amongst others, measurements of elicited surface pressure and a comprehensive microcirculatory analysis were carried out by utilizing an O2C-device. For the detection of (systemic) remote effects, perfusion changes of the contra-lateral thigh were evaluated. ResultsAll three tested modes of application led to a significant (p < 0.05) improvement in local tissue perfusion with an increased blood flow of max +151% and tissue oxygen saturation of +28.2% compared to baseline values. Surface pressure under the dressing significantly increased up to 29.29 mmHg due to the activation of the NPWT device. Continuous, intermittent, and cyclic application of negative pressure were accurately sensed by participants, resulting in reported pain values that mirrored the different levels of applied suction. Although the cyclic application mode showed the most pronounced effects regarding microcirculatory changes, no statistical significance between groups was observed. ConclusionWe could demonstrate a significant improvement of cutaneous microcirculation under an applied NPWT dressing with favorable effects due to cyclic mode of application. An increased surface pressure leads to a better venous drainage of the tissue, which was shown to increase arterial inflow with a consecutive improvement of oxygen supply. Further research is warranted to evaluate our findings regarding wound bed perfusion in the clinical field with respect to formation of granulation tissue and wound healing.
C1 [Sogorski, Alexander; Becker, Amira; Dadras, Mehran; Wallner, Chtistoph; Wagner, Johannes Maximillian; Glinski, Maxi, V; Lehnhardt, Marcus; Behr, Bjoern] Ruhr Univ Bochum, BG Univ Hosp Bergmannsheil Bochum, Burn Ctr, Dept Plast Surg & Hand Surg, Bochum, Germany.
C3 Ruhr University Bochum
RP Sogorski, A (通讯作者)，Ruhr Univ Bochum, BG Univ Hosp Bergmannsheil Bochum, Burn Ctr, Dept Plast Surg & Hand Surg, Bochum, Germany.
EM alexander.sogorski@rub.de
RI Behr, Björn/AAS-1877-2021; Dadras, Mehran/R-2089-2019
FU Junior Clinician Scientist program by the FoRUM-program of the medical
   faculty of the RuhrUniversity Bochum [K128-19]
FX AS received a grant from the Junior Clinician Scientist program by the
   FoRUM-program of the medical faculty of the RuhrUniversity Bochum
   (K128-19).
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NR 26
TC 4
Z9 4
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD MAR 3
PY 2022
VL 9
AR 822122
DI 10.3389/fsurg.2022.822122
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 1J4SY
UT WOS:000797910800001
PM 35310447
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Boll, G
   Callas, P
   Bertges, DJ
AF Boll, Griffin
   Callas, Peter
   Bertges, Daniel J.
TI Meta-analysis of prophylactic closed-incision negative pressure wound
   therapy for vascular surgery groin wounds
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 48th Annual Meeting of the New-England-Society-for-Vascular-Surgery
CY SEP 15-OCT 17, 2021
CL Cape Neddick, ME
DE Negative pressure wound therapy; Surgical site infections; Wound
   complications
ID SURGICAL-SITE INFECTION; VEIN BYPASS; COMPLICATIONS; PREVENTION;
   PREDICTORS; SOCIETY; TRIALS; GENDER; IMPACT
AB Objective: A previous meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy of closed incision negative pressure wound therapy (ciNPWT) on vascular surgery groin wounds reported a reduction in surgical site infections (SSIs). Our aim was to perform a comprehensive, updated meta-analysis after the largest multicenter RCT on the subject to date reported no benefits from ciNPWT.
   Methods: A systematic review identified RCTs that had compared the primary outcome of the incidence of postoperative SSIs of groin incisions treated with ciNPWT or standard dressings. The secondary outcomes included wound dehiscence, a composite incidence of seroma, lymph leakage, and hematoma, the need for reoperation, in-hospital mortality, the need for readmission, and the hospital length of stay. The odds ratios (ORs) were compared across the studies using a random effects meta-analysis. The risk of bias was assessed using the Cochrane risk of bias tool, Harbord test, and trim-and-fill analysis.
   Results: Eight RCTs with 1125 incisions (ciNPWT, n = 555 [49.3%]; control, n = 570 [50.7%]) were included. The RCTs included three studies inside and five outside the United States. ciNPWT was associated with a significant reduction in the rate of SSIs (OR, 0.39; 95% confidence interval [CI], 0.24-0.63; P < .001). No significant differences were found in the rate of wound dehiscence (OR, 1.11; 95% CI, 0.67-1.83; P = .68), composite incidence of seroma, lymph leak, or hematoma (OR, 0.49; 95% CI, 0.13-1.76; P = .27), need for reoperation (OR, 0.68; 95% CI, 0.40-1.16; P = .16), or need for readmission (OR, 0.60; 95% CI, 0.30-1.21; P = .15). It was not possible to quantitatively evaluate in-hospital mortality or the hospital length of stay. The risk of bias assessment identified a high risk of bias for participant blinding in all eight studies, a low risk for randomization and outcome reporting, and variability between studies for the other methods. We found no evidence of publication bias.
   Conclusions: Our meta-analysis of pooled data has suggested that prophylactic use of ciNPWT for vascular groin incisions will be associated with reduced rates of SSIs. The greatest benefits were seen in the trials with higher baseline rates of SSIs in the control group.
C1 [Boll, Griffin; Bertges, Daniel J.] Univ Vermont, Dept Surg, Med Ctr, 111 Colchester Ave, Burlington, VT 05401 USA.
   [Callas, Peter] Univ Vermont, Dept Med Biostat, Burlington, VT 05401 USA.
C3 University of Vermont Medical Center; University of Vermont; University
   of Vermont
RP Bertges, DJ (通讯作者)，Univ Vermont, Dept Surg, Med Ctr, 111 Colchester Ave, Burlington, VT 05401 USA.
EM daniel.bertges@uvmhealth.org
CR Antoniou GA, 2019, J VASC SURG, V70, P1700, DOI 10.1016/j.jvs.2019.01.083
   Arnaoutakis DJ, 2017, J VASC SURG, V65, P1713, DOI 10.1016/j.jvs.2016.12.116
   Ban KA, 2017, J AM COLL SURGEONS, V224, P59, DOI 10.1016/j.jamcollsurg.2016.10.029
   Bertges DJ, 2021, J VASC SURG, V74, P257, DOI 10.1016/j.jvs.2020.12.100
   Coomer NM, 2016, AM J INFECT CONTROL, V44, P1326, DOI 10.1016/j.ajic.2016.03.025
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   WILSON APR, 1986, LANCET, V1, P311
NR 31
TC 27
Z9 28
U1 3
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD JUN
PY 2022
VL 75
IS 6
BP 2086
EP +
DI 10.1016/j.jvs.2021.12.070
EA MAY 2022
PG 17
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA 1K0NF
UT WOS:000798307600036
PM 34999218
OA Bronze
DA 2026-07-24
ER
PT J
AU Kosugi, K
   Zenke, Y
   Sato, N
   Hamada, D
   Ando, K
   Okada, Y
   Yamanaka, Y
   Sakai, A
AF Kosugi, Kenji
   Zenke, Yukichi
   Sato, Naohito
   Hamada, Daishi
   Ando, Kohei
   Okada, Yasuaki
   Yamanaka, Yoshiaki
   Sakai, Akinori
TI Potential of Continuous Local Antibiotic Perfusion Therapy for
   Fracture-Related Infections
SO INFECTIOUS DISEASES AND THERAPY
LA English
DT Article
DE Continuous local antibiotic perfusion; Fracture-related infections;
   Gentamicin; Negative-pressure wound therapy
ID GENTAMICIN; PROPHYLAXIS; BEADS; INJECTION; CEMENT
AB Introduction Fracture-related infections (FRIs) are challenging for orthopedic surgeons, as conventional surgical treatment and systemic antimicrobial therapy cannot completely control local infections. Continuous local antibiotic perfusion (CLAP) is a novel and innovative therapy for bone and soft-tissue infections, and is expected to eradicate biofilms by maintaining a sustained high concentration of antimicrobial agents at the infected site. If CLAP therapy can eradicate infection even in cases with implants while preserving the implants, it would be an ideal and effective treatment for local refractory infections. This study aimed to evaluate the usefulness of novel CLAP therapy for FRIs. Methods Nine patients treated with CLAP therapy were retrospectively analyzed. The mean age was 65.9 (43-82) years, and the mean follow-up period was 14.9 (6-45) months. In all cases, the infected sites were related to the lower extremities (tibia, n = 6; fibula, n = 1; hip joint, n = 1; foot, n = 1). All patients underwent similar procedures for this therapy combined with negative-pressure wound therapy after thorough irrigation and debridement of infected tissues. Results The pathogens identified were Staphylococcus aureus (methicillin-resistant S. aureus, n = 5; methicillin-susceptible S. aureus, n = 1), Pseudomonas aeruginosa (n = 3), Enterococcus faecalis (n = 2), Corynebacterium (n = 1), and Enterobacter (n = 1); pathogens were not detected in one case. The mean duration of CLAP was 17.0 (7-35) days. In all cases, implants were preserved until bone union was achieved. Five cases relapsed; however, infection was finally suppressed in all cases by repeating this method. No side effects were observed. Conclusion This novel case series presents treatment outcomes using CLAP therapy for FRIs. This method has the potential to control the infection without removing the implants, because of the sustained high concentration of antimicrobial agents at the infected site, and could be a valuable treatment option for refractory FRIs with implants, in which bone union has not been achieved.
C1 [Kosugi, Kenji; Okada, Yasuaki; Yamanaka, Yoshiaki; Sakai, Akinori] Univ Occupat & Environm Hlth, Dept Orthopaed Surg, Kitakyushu, Fukuoka, Japan.
   [Zenke, Yukichi; Sato, Naohito; Hamada, Daishi; Ando, Kohei] Univ Occupat & Environm Hlth, Dept Emergency Med, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.
C3 University of Occupational & Environmental Health - Japan; University of
   Occupational & Environmental Health - Japan
RP Zenke, Y (通讯作者)，Univ Occupat & Environm Hlth, Dept Emergency Med, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.
EM k.kosugi0924@gmail.com; ukichi.drz@gmail.com; naotu0722@yahoo.co.jp;
   olewaeconaotoco0608@gmail.com; koheiando@mac.com; 0713yasuaki@gmail.com;
   yamanaka@med.uoeh-u.ac.jp; a-sakai@med.uoeh-u.ac.jp
OI Kosugi, Kenji/0000-0003-1183-2921; Ando, Kohei/0000-0002-6623-477X;
   Sakai, Akinori/0000-0002-6023-5536
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NR 32
TC 23
Z9 30
U1 0
U2 3
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 2193-8229
EI 2193-6382
J9 INFECT DIS THER
JI Infect. Dis. Ther.
PD AUG
PY 2022
VL 11
IS 4
BP 1741
EP 1755
DI 10.1007/s40121-022-00653-5
EA MAY 2022
PG 15
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 3I6QB
UT WOS:000798472700001
PM 35596921
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gregorík, M
   Szkorupa, M
   Chudácek, J
AF Gregorik, M.
   Szkorupa, M.
   Chudacek, J.
TI Negative Pressure Wound Therapy as a Treatment Option for Extensive
   Post-Trauma Subcutaneous Emphysema
SO ACTA CHIRURGIAE ORTHOPAEDICAE ET TRAUMATOLOGIAE CECHOSLOVACA
LA Czech
DT Article
DE negative pressure wound therapy; subcutaneous emphysema; rib fracture
ID MANAGEMENT
AB Subcutaneous emphysema can be a secondary complication of chest trauma or one of the complications of ruptured bullae in advanced chronic obstructive pulmonary disease. Massive subcutaneous emphysema impairs the respiratory mechanics and affects the venous returns of the head and neck. It can lead to respiratory insufficiency with the need for mechanical ventilation. The treatment should focus on the primary pathology. Nonetheless, in patients with subcutaneous emphysema as the only but serious symptom, the treatment can zero in solely on this complication. The standard procedure consists in the insertion of chest drain which does not necessarily have to lead to successful treatment results. The authors present a case study of a 77-year-old man with major comorbidities, with extensive subcutaneous emphysema after blunt chest wall trauma, in which respiratory insufficiency developed. The chest drain was ineffective. The solution was to apply subfascial negative pressure therapy infraclavicularly to the area of the pectoral muscle, which made the subcutaneous emphysema almost immediately subside and which substantially improved the clinical condition of the patient. Local negative pressure therapy can be used as the method of choice for treating massive subcutaneous emphysema in patients, in whom the standardised treatment by chest drain with active suction mechanism failed and the lung is expanded in the pleural cavity, and for whom surgery is far too risky.
C1 [Chudacek, J.] Univerz Palackeho Olomouci, Chirurg Klin Fak Nemocnice 1, Olomouc, Czech Republic.
   Univerz Palackeho Olomouci, Lekarske Fak, Olomouc, Czech Republic.
RP Chudácek, J (通讯作者)，I Chirurg Klin FN, IP Pavlova 185-6, Olomouc 77900, Czech Republic.; Chudácek, J (通讯作者)，LF UP Olomouci, IP Pavlova 185-6, Olomouc 77900, Czech Republic.
EM josef.chudacek@fnol.cz
RI /AAP-7370-2020; /ABH-5345-2020
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NR 8
TC 0
Z9 0
U1 0
U2 0
PU GALEN SRO
PI PRAGUE 5
PA NA BELIDLE 34, PRAGUE 5, 150 00, CZECH REPUBLIC
SN 0001-5415
J9 ACTA CHIR ORTHOP TR
JI Acta Chir. Orthop. Traumatol. Cechoslov.
PY 2021
VL 88
IS 6
BP 464
EP 467
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 1K7ZW
UT WOS:000798817200011
PM 34998452
DA 2026-07-24
ER
PT J
AU Chen, P
   Carville, K
   Swanson, T
   Lazzarini, PA
   Charles, J
   Cheney, J
   Prentice, J
AF Chen, Pamela
   Carville, Keryln
   Swanson, Terry
   Lazzarini, Peter A.
   Charles, James
   Cheney, Jane
   Prentice, Jenny
CA Australian Diabetes-Related Foot D
TI Australian guideline on wound healing interventions to enhance healing
   of foot ulcers: part of the 2021 Australian evidence-based guidelines
   for diabetes-related foot disease
SO JOURNAL OF FOOT AND ANKLE RESEARCH
LA English
DT Article
DE Diabetes-related foot ulcer; Diabetic foot; Foot ulcer; guideline;
   Recommendations; Treatment; Wound healing; Wound treatment
ID HYPERBARIC-OXYGEN THERAPY; LOWER-EXTREMITY ULCERS; DOUBLE-BLIND; SUCROSE
   OCTASULFATE; TOPICAL PHENYTOIN; CONTROLLED-TRIAL; MANAGEMENT;
   MULTICENTER; EFFICACY; PREVENTION
AB Background: Diabetes-related foot ulceration (DFU) has a substantial burden on both individuals and healthcare systems both globally and in Australia. There is a pressing need for updated guidelines on wound healing interventions to improve outcomes for people living with DFU. A national expert panel was convened to develop new Australian evidence-based guidelines on wound healing interventions for people with DFU by adapting suitable international guidelines to the Australian context
   Methods: The panel followed National Health and Medical Research Council (NHMRC) procedures to adapt suitable international guidelines by the International Working Group of the Diabetic Foot (IWGDF) to the Australian context. The panel systematically screened, assessed and judged all IWGDF wound healing recommendations using ADAPTE and GRADE frameworks for adapting guidelines to decide which recommendations should be adopted, adapted or excluded in the Australian context. Each recommendation had their wording, quality of evidence, and strength of recommendation re-evaluated, plus rationale, justifications and implementation considerations provided for the Australian context. This guideline underwent public consultation, further revision and approval by ten national peak bodies.
   Results: Thirteen IWGDF wound healing recommendations were evaluated in this process. After screening, nine recommendations were adopted and four were adapted after full assessment. Two recommendations had their strength of recommendations downgraded, one intervention was not currently approved for use in Australia, one intervention specified the need to obtain informed consent to be acceptable in Australia, and another was reworded to clarify best standard of care. Overall, five wound healing interventions have been recommended as having the evidence-based potential to improve wound healing in specific types of DFU when used in conjunction with other best standards of DFU care, including sucrose-octasulfate impregnated dressing, systemic hyperbaric oxygen therapy, negative pressure wound therapy, placental-derived products, and the autologous combined leucocyte, platelet and fibrin dressing. The six new guidelines and the full protocol can be found at https://diabetesfeetaustralia.org/new-guidelines/
   Conclusions: The IWGDF guideline for wound healing interventions has been adapted to suit the Australian context, and in particular for geographically remote and Aboriginal and Torres Strait Islander people. This new national wound healing guideline, endorsed by ten national peak bodies, also highlights important considerations for implementation, monitoring, and future research priorities in Australia.
C1 [Chen, Pamela] Univ Tasmania, Sch Med, Hobart, Tas, Australia.
   [Chen, Pamela] Univ Western Australia, Sch Allied Hlth, Podiatr Med & Surg, Perth, WA, Australia.
   [Chen, Pamela] Ramsay Healthcare Australia, Joondalup Hlth Campus, Perth, WA, Australia.
   [Carville, Keryln] Silver Chain Grp, Perth, WA, Australia.
   [Carville, Keryln] Curtin Univ, Perth, WA, Australia.
   [Lazzarini, Peter A.] Queensland Univ Technol, Sch Publ Hlth & Social Work, Brisbane, Qld, Australia.
   [Lazzarini, Peter A.] Prince Charles Hosp, Allied Hlth Res Collaborat, Brisbane, Qld, Australia.
   [Charles, James] Griffith Univ, Peoples Hlth Unit 1, Fac Hlth, Gold Coast, Qld, Australia.
   [Cheney, Jane] Diabet Victoria, Melbourne, Vic, Australia.
   [Prentice, Jenny] Hall & Prior Hlth & Aged Care Grp, Perth, WA, Australia.
   Diabet Feet Australia, Brisbane, Qld, Australia.
   [Australian Diabetes-Related Foot D] Australian Diabet Soc, Sydney, NSW, Australia.
C3 University of Tasmania; University of Western Australia; Curtin
   University; Queensland University of Technology (QUT); Prince Charles
   Hospital; Griffith University
RP Chen, P (通讯作者)，Univ Tasmania, Sch Med, Hobart, Tas, Australia.; Chen, P (通讯作者)，Univ Western Australia, Sch Allied Hlth, Podiatr Med & Surg, Perth, WA, Australia.; Chen, P (通讯作者)，Ramsay Healthcare Australia, Joondalup Hlth Campus, Perth, WA, Australia.
EM pamelachen@iinet.net.au
OI Lazzarini, Peter/0000-0002-8235-7964; Chen, Pamela/0000-0001-8082-5050
FU National Diabetes Services Scheme; Australian Diabetes Society
FX The Australian Diabetes-related Foot Disease Guidelines & Pathways
   Project received part funding from the National Diabetes Services Scheme
   and inkind secretariat support and oversight from Diabetic Foot
   Australia and the Australian Diabetes Society.
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NR 56
TC 20
Z9 25
U1 2
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1757-1146
J9 J FOOT ANKLE RES
JI J. Foot Ankle Res.
PD MAY 25
PY 2022
VL 15
IS 1
AR 40
DI 10.1186/s13047-022-00544-5
PG 24
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 1M2LC
UT WOS:000799804300001
PM 35610723
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Matar, DY
   Ng, B
   Darwish, O
   Wu, MF
   Orgill, DP
   Panayi, AC
AF Matar, Dany Y.
   Ng, Brian
   Darwish, Oliver
   Wu, Mengfan
   Orgill, Dennis P.
   Panayi, Adriana C.
TI Skin Inflammation with a Focus on Wound Healing
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE wound healing; inflammation; negative pressure wound therapy; diabetic
   wound; chronic wound; tissue regeneration
ID GENE-RELATED PEPTIDE; TOXIC EPIDERMAL NECROLYSIS; STEVENS-JOHNSON
   SYNDROME; VACUUM-ASSISTED CLOSURE; NECROSIS-FACTOR-ALPHA; SUBSTANCE-P;
   DENDRITIC CELLS; HIDRADENITIS SUPPURATIVA; PYODERMA-GANGRENOSUM; IN-VIVO
AB Significance: The skin is the crucial first-line barrier against foreign pathogens. Compromise of this barrier presents in the context of inflammatory skin conditions and in chronic wounds. Skin conditions arising from dysfunctional inflammatory pathways severely compromise the quality of life of patients and have a high economic impact on the U.S. health care system. The development of a thorough understanding of the mechanisms that can disrupt skin inflammation is imperative to successfully modulate this inflammation with therapies.Recent Advances: Many advances in the understanding of skin inflammation have occurred during the past decade, including the development of multiple new pharmaceuticals. Mechanical force application has been greatly advanced clinically. Bioscaffolds also promote healing, while reducing scarring.Critical Issues: Various skin inflammatory conditions provide a framework for analysis of our understanding of the phases of successful wound healing. The large burden of chronic wounds on our society continues to focus attention on the chronic inflammatory state induced in many of these skin conditions.Future Directions: Better preclinical models of disease states such as chronic wounds, coupled with enhanced diagnostic abilities of human skin, will allow a better understanding of the mechanism of action. This will lead to improved treatments with biologics and other modalities such as the strategic application of mechanical forces and scaffolds, which ultimately results in better outcomes for our patients.
C1 [Matar, Dany Y.; Ng, Brian; Darwish, Oliver; Wu, Mengfan; Orgill, Dennis P.; Panayi, Adriana C.] Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA USA.
   [Matar, Dany Y.] Washington Univ St Louis, Dept Biol, St Louis, MO USA.
   [Ng, Brian] St Louis Univ, Dept Med, Sch Med, St Louis, MO USA.
   [Darwish, Oliver] Calif Northstate Univ, Dept Med, Coll Med, Elk Grove, CA USA.
   [Wu, Mengfan] Peking Univ, Dept Plast Surg, Shenzhen Hosp, Shenzhen, Peoples R China.
   [Orgill, Dennis P.; Panayi, Adriana C.] Brigham & WomensHospital & Harvard Med Sch, Dept Surg, Div Plast Surg, 75 FrancisStreet, Boston, MA 02115 USA.
   [Matar, Dany Y.; Ng, Brian; Darwish, Oliver; Wu, Mengfan; Orgill, Dennis P.; Panayi, Adriana C.] Harvard Med Sch, Boston, MA USA.
   [Orgill, Dennis P.; Panayi, Adriana C.] Harvard Med Sch, 75 Francis St, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Washington University (WUSTL); Saint Louis University;
   Peking University; Harvard University; Harvard Medical School; Harvard
   University; Harvard Medical School
RP Orgill, DP; Panayi, AC (通讯作者)，Brigham & WomensHospital & Harvard Med Sch, Dept Surg, Div Plast Surg, 75 FrancisStreet, Boston, MA 02115 USA.; Orgill, DP; Panayi, AC (通讯作者)，Harvard Med Sch, Boston, MA USA.; Orgill, DP; Panayi, AC (通讯作者)，Harvard Med Sch, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@bwh.harvard.edu; apanayi@bwh.harvard.edu
RI ; Panayi, Adriana/HHT-0513-2022; Orgill, Dennis/H-7596-2019
OI Matar, Dany/0000-0001-7108-0413; Panayi, Adriana/0000-0003-4053-9855;
   Wu, Mengfan/0000-0003-2646-3372; Orgill, Dennis/0000-0002-8279-7310
FU The Gillian Reny Stepping Strong Center for Trauma Innovation
   [T35HL110843]; NIH; National Heart Lung and Blood Institute
   [T35HL110843] Funding Source: NIH RePORTER
FX This work was funded by The Gillian Reny Stepping Strong Center for
   Trauma Innovation and is in part supported by NIH T35HL110843 fellowship
   to Brian Ng.
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NR 193
TC 56
Z9 61
U1 4
U2 63
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAY 1
PY 2023
VL 12
IS 5
BP 269
EP 287
DI 10.1089/wound.2021.0126
EA MAY 2022
PG 19
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 9D8GO
UT WOS:000802665800001
PM 35287486
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Wang, C
   Zhang, JX
   Liu, ZZ
AF Wang, Chao
   Zhang, Jixun
   Liu, Zhenzhong
TI Stool Management Followed by Surgical Debridement and Surgical Closure
   Combined With Negative Pressure Wound Therapy in the Treatment of
   Posterior Trunk Pressure Injury: A Retrospective Descriptive Study
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE pressure injury; negative pressure wound therapy; infection; stool
   management; retrospective descriptive study
ID PARENTERAL-NUTRITION; ULCERS; RISK; COMPLICATIONS; PREVENTION; SUPPORT;
   IMPACT; DEVICE
AB BACKGROUND: Pressure injuries are a burden to patients and the health care system, and negative pressure wound therapy (NPWT) is a widely used treatment. PURPOSE: This study sought to assess the effect of stool management followed by surgi-cal debridement and surgical closure combined with NPWT in the treatment of posterior trunk pressure injuries. METHODS: A retrospective descriptive study was conducted in patients with stage 3 or 4 posterior trunk pressure injuries by reviewing electronic health records. The collected variables included sex, age, height, weight, initial underlying disease leading to being bedridden, stage and anatomical location of pressure injury, stool frequency, pathogens, number of NPWT applications, com-plications related to surgical closure, outcome, and treatment time. Fasting and enema were used to reduce the frequency of defecation, followed by surgical debridement and surgical closure combined with NPWT. RESULTS: Among the 63 eligible pa-tients, 35 were male and 28 were female (average age, 72.3 +/- 11.3 years). The patients' weight before fasting and after fasting showed no significant difference (62.6 +/- 11.2 kg vs 61.6 +/- 10.2 kg; 95% confidence interval, -2.78-4.76; P = .60). Stage 3 and stage 4 accounted for 33 (52.4%) and 30 (47.6%) pressure injuries, respectively. There were 36 (57.1%) pressure injuries located on the sacrum, and the remaining 27 (42.9%) were located in the ischia. Underlying causes for being bedridden were cardiopulmonary insufficiency (n = 23; 36.5%), severe brain damage and cerebrovascular accident (n = 19; 30.2%), spinal cord injury (n = 12; 19.0%), and others (14.3%). The wound closure rate was 96.8% (n = 61), with a mean hospital stay of 22.3 days. These patients underwent 1 to 3 cycles of NPWT before surgical wound closure. Escherichia coli, Staphylococ-cus aureus, and Pseudomonas aeruginosa were the most common pathogens. The complications related to surgical closure (defined as complications that occurred from surgical closure until 30 days later) occurred in 7 patients (11.1%); 3 patients (4.8%) experienced a pressure injury recurrence. CONCLUSION: The treatment approach reported here was effective in these patients with posterior trunk pressure injuries. A satisfactory cure rate, manageable complications, and rare recurrence were achieved. Parenteral nutrition after fasting maintained patients' weight without significant loss. Prospective randomized controlled trials involving larger samples and longer follow-up times are needed
C1 [Wang, Chao; Zhang, Jixun; Liu, Zhenzhong] Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Burn & Plast Surg, Jinan 250033, Shandong, Peoples R China.
   [Wang, Chao] Shandong Univ, Cheeloo Coll Med, Jinan, Peoples R China.
C3 Shandong University; Shandong University
RP Liu, ZZ (通讯作者)，Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Burn & Plast Surg, Jinan 250033, Shandong, Peoples R China.
EM drliuzhenzhong@163.com
CR [Anonymous], 2019, The International Guideline
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NR 44
TC 1
Z9 1
U1 0
U2 8
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD APR
PY 2022
VL 68
IS 4
BP 26
EP 33
DI 10.25270/wmp.2022.4.2633
PG 8
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA 1Q6LQ
UT WOS:000802796700002
PM 35544779
DA 2026-07-24
ER
PT J
AU Giuglea, C
   Burlacu, EC
   Dumitrache, S
   Tene, MG
   Marin, A
   Jianu, DM
   Marinescu, SA
AF Giuglea, Carmen
   Burlacu, Elena-Cristina
   Dumitrache, Serban
   Tene, Mirela-Georgiana
   Marin, Andrei
   Jianu, Dana Mihaela
   Marinescu, Silviu-Adrian
TI Negative Pressure Wound Therapy in Postbariatric Lower Body Lift-A
   Method of Decreasing Postoperative Complications
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Lower body lifting; Negative pressure wound therapy; postbariatric
   surgery
ID VACUUM-ASSISTED CLOSURE; CONTOURING SURGERY; ABDOMINOPLASTY; TRIAL
AB Background Lower body lift procedure is one of the most common procedures in postbariatric surgery, which can be followed by postoperative complications that delay the healing time. The purpose of this study was to analyse whether the use of negative pressure wound therapy (NPWT) as a replacement for the classical drainage method would provide better postoperative results with fewer complications.
   Methods The authors reviewed their experience with 46 consecutive patients that underwent lower body lift surgery from 2018 to 2021. They were divided into two groups: 23 of them received NPWT as drainage method and another 23 received classical active drains. We assessed the complication rates and types between the two groups to demonstrate the efficiency of NPWT as a support in the surgical protocol.
   Results Forty-six patients were included in this study. Two equal groups formed by 23 patients were analysed for age, sex, type of weight loss, type of circumferential lower body lift, type of drainage, quantity of drainage, time of drain usance, postoperative complications, operation time, hospital stay and frequency of hospital visits. The group that received NPWT had a 26.08% rate of complications as compared with the drain group that had a 47.8% complication rate.
   Conclusions This study is performed as a comparison between negative pressure wound therapy and classical drainage method in lower body lift surgery, as a new method of reducing the postoperative complications. By achieving faster closure of large, undermining areas, it concludes in a lower risk of seroma or hematoma formation.
C1 [Giuglea, Carmen; Burlacu, Elena-Cristina; Dumitrache, Serban; Tene, Mirela-Georgiana] Clin Emergency Hosp SE Ioan, Bucharest, Romania.
   [Dumitrache, Serban; Marin, Andrei; Marinescu, Silviu-Adrian] Carol Davila Univ Med & Pharm, Bucharest, Romania.
   [Jianu, Dana Mihaela] Int Soc Regenerat Med & Surg, ProEstet Med, Bucharest, Romania.
   [Marinescu, Silviu-Adrian] Clin Emergency Hosp Bagdasar Arseni, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Burlacu, EC (通讯作者)，Clin Emergency Hosp SE Ioan, Bucharest, Romania.
EM giugleacarmen@yahoo.com; elena.burlacu89@gmail.com;
   serban_dumitrache@yahoo.com; tenemirela95@gmail.com;
   marin_dpt@yahoo.com; djianu02@gmail.com; silviumarinescu@hotmail.com
RI Marin, Andrei/GQH-7170-2022; /A-1434-2015
OI Marin, Andrei/0000-0002-5188-696X; Burlacu, Elena/0000-0002-4122-1315; 
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NR 29
TC 4
Z9 4
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD DEC
PY 2022
VL 46
IS 6
BP 2882
EP 2890
DI 10.1007/s00266-022-02911-w
EA MAY 2022
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9B2AX
UT WOS:000803818000006
PM 35641686
DA 2026-07-24
ER
PT J
AU Cheng, Y
   Wang, K
   Gong, JH
   Liu, ZJ
   Gong, JP
   Zeng, Z
   Wang, XM
AF Cheng, Yao
   Wang, Ke
   Gong, Junhua
   Liu, Zuojin
   Gong, Jianping
   Zeng, Zhong
   Wang, Xiaomei
TI Negative pressure wound therapy for managing the open abdomen in
   non-trauma patients
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID TEMPORARY ABDOMINAL CLOSURE; MEDIATED FASCIAL TRACTION;
   PROGNOSTIC-FACTORS; DELAYED CLOSURE; SEPTIC PATIENTS; MANAGEMENT;
   VACUUM; SURGERY; RECOMMENDATIONS; METAANALYSIS
AB Background
   Management of the open abdomen is a considerable burden for patients and healthcare professionals. Various temporary abdominal closure techniques have been suggested for managing the open abdomen. In recent years, negative pressure wound therapy (NPWT) has been used in some centres for the treatment of non-trauma patients with an open abdomen; however, its effectiveness is uncertain.
   Objectives
   To assess the effects of negative pressure wound therapy (NPWT) on primary fascial closure for managing the open abdomen in non-trauma patients in any care setting.
   Search methods
   In October 2021 we searched the Cochrane Wounds Specialised Register, CENTRAL, MEDLINE, Embase, and CINAHL EBSCO Plus. To identify additional studies, we also searched clinical trials registries for ongoing and unpublished studies, and scanned reference lists of relevant included studies as well as reviews, meta-analyses, and health technology reports. There were no restrictions with respect to language, date of publication, or study setting.
   Selection criteria
   We included all randomised controlled trials (RCTs) that compared NPWT with any other type of temporary abdominal closure (e.g. Bogota bag, Wittmann patch) in non-trauma patients with open abdomen in any care setting. We also included RCTs that compared different types of NPWT systems for managing the open abdomen in non-trauma patients.
   Data collection and analysis
   Two review authors independently performed the study selection process, risk of bias assessment, data extraction, and GRADE assessment of the certainty of evidence.
   Main results
   We included two studies, involving 74 adults with open abdomen associated with various conditions, predominantly severe peritonitis (N = 55). The mean age of the participants was 52.8 years; the mean proportion of women was 39.2%. Both RCTs were carried out in single centres and were at high risk of bias.
   Negative pressure wound therapy versus Bogota bag
   We included one study (40 participants) comparing NPWT with Bogota bag. We are uncertain whether NPWT reduces time to primary fascial closure of the abdomen (NPWT: 16.9 days versus Bogota bag: 20.5 days (mean difference (MD) -3.60 days, 95% confidence interval (CI) -8.16 to 0.96); very low-certainty evidence) or adverse events (fistulae formation, NPWT: 10% versus Bogota: 5% (risk ratio (RR) 2.00, 95% CI 0.20 to 20.33); very low-certainty evidence) compared with the Bogota bag. We are also uncertain whether NPWT reduces all-cause mortality (NPWT: 25% versus Bogota bag: 35% (RR 0.71, 95% CI 0.27 to 1.88); very low-certainty evidence) or length of hospital stay compared with the Bogota bag (NPWT mean: 28.5 days versus Bogota bag mean: 27.4 days (MD 1.10 days, 95% CI -13.39 to 15.59); very low-certainty evidence). The study did not report the proportion of participants with successful primary fascial closure of the abdomen, participant health-related quality of life, reoperation rate, wound infection, or pain.
   Negative pressure wound therapy versus any other type of temporary abdominal closure
   There were no randomised controlled trials comparing NPWT with any other type of temporary abdominal closure.
   Comparison of different negative pressure wound therapy devices
   We included one study (34 participants) comparing different types of NPWT systems (Suprasorb CNP system versus ABThera system). We are uncertain whether the Suprasorb CNP system increases the proportion of participants with successful primary fascial closure of the abdomen compared with the ABThera system (Suprasorb CNP system: 88.2% versus ABThera system: 70.6% (RR 0.80, 95% CI 0.56 to 1.14); very low-certainty evidence). We are also uncertain whether the Suprasorb CNP system reduces adverse events (fistulae formation, Suprasorb CNP system: 0% versus ABThera system: 23.5% (RR 0.11, 95% CI 0.01 to 1.92); very low-certainty evidence), all-cause mortality (Suprasorb CNP system: 5.9% versus ABThera system: 17.6% (RR 0.33, 95% CI 0.04 to 2.89); very low-certainty evidence), or reoperation rate compared with the ABThera system (Suprasorb CNP system: 100% versus ABThera system: 100% (RR 1.00, 95% CI 0.90 to 1.12); very low-certainty evidence). The study did not report the time to primary fascial closure of the abdomen, participant health-related quality of life, length of hospital stay, wound infection, or pain.
   Authors' conclusions
   Based on the available trial data, we are uncertain whether NPWT has any benefit in primary fascial closure of the abdomen, adverse events (fistulae formation), all-cause mortality, or length of hospital stay compared with the Bogota bag. We are also uncertain whether the Suprasorb CNP system has any benefit in primary fascial closure of the abdomen, adverse events, all-cause mortality, or reoperation rate compared with the ABThera system. Further research evaluating these outcomes as well as participant health-related quality of life, wound infection, and pain outcomes is required. We will update this review when data from the large studies that are currently ongoing are available.
C1 [Cheng, Yao; Wang, Ke; Liu, Zuojin; Gong, Jianping; Wang, Xiaomei] Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing, Peoples R China.
   [Gong, Junhua; Zeng, Zhong] Kunming Med Univ, Organ Transplant Ctr, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China.
C3 Chongqing Medical University; Kunming Medical University
RP Wang, XM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing, Peoples R China.
EM 300394@hospital.cqmu.edu.cn
RI ; gong, junhua/HTO-5296-2023
OI Gong, Junhua/0009-0003-2245-9007; 
FU National Institute for Health Research (NIHR), UK; National Institute
   for Health Research
FX The National Institute for Health Research (NIHR), UK This project was
   supported by the National Institute for Health Research, via Cochrane
   Infrastructure funding to Cochrane Wounds. The views expressed are those
   of the authors and not necessarily those of the NIHR or the Department
   of Health and Social Care.
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NR 74
TC 13
Z9 25
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2022
IS 5
AR CD013710
DI 10.1002/14651858.CD013710.pub2
PG 41
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1S5YF
UT WOS:000804126100010
PM 35514120
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Herrod, PJ
   Doleman, B
   Hardy, EJ
   Hardy, P
   Maloney, T
   Williams, JP
   Lund, JN
AF Herrod, Philip J.
   Doleman, Brett
   Hardy, Edward J.
   Hardy, Paul
   Maloney, Trevor
   Williams, John P.
   Lund, Jon N.
TI Dressings and topical agents for the management of open wounds after
   surgical treatment for sacrococcygeal pilonidal sinus
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID SECONDARY INTENTION; EXCISION; DISEASE; SURGERY; TRIAL; COMPLICATIONS;
   METAANALYSIS; DURATION; COLLAGEN; THERAPY
AB Background
   Sacrococcygeal pilonidal sinus disease is a common debilitating condition that predominantly affects young adults, with a profound impact on their activities of daily living. The condition is treated surgically, and in some cases the wound in the natal cleft is left open to heal by itself. Many dressings and topical agents are available to aid healing of these wounds.
   Objectives
   To assess the effects of dressings and topical agents for the management of open wounds following surgical treatment for sacrococcygeal pilonidal sinus in any care setting.
   Search methods
   In March 2021, we searched the Cochrane Wounds Specialised Register, CENTRAL, MEDLINE, Embase and EBSCO CINAHL Plus. We also searched clinical trials registries for ongoing and unpublished studies, and we scanned reference lists of included studies, reviews, meta-analyses and health technology reports to identify additional studies. There were no restrictions with respect to language, date of publication or study setting.
   Selection criteria
   We included parallel-group randomised controlled trials (RCTs) only. We included studies with participants who had undergone any type of sacrococcygeal pilonidal sinus disease surgery and were left with an open wound.
   Data collection and analysis
   We used the standard methodological procedures expected by Cochrane. We used GRADE to assess the certainty of the evidence for each outcome.
   Main results
   We included 11 RCTs comprising 932 participants. Two studies compared topical negative pressure wound therapy (TNPWT) with conventional open wound healing, two studies compared platelet-rich plasma with sterile absorbent gauze, and the other seven studies compared various dressings and topical agents. All studies were at high risk of bias in at least one domain, whilst one study was judged to be at low risk of bias in all but one domain. All studies were conducted in secondary care. Mean participant ages were between 20 and 30 years, and nearly 80% of participants were male. No studies provided data on quality of life, cost-effectiveness, pain at first dressing change or proportion of wounds healed at 6 or 12 months, and very few adverse effects were recorded in any study.
   It is unclear whether TNPWT reduces time to wound healing compared with conventional open wound healing (comparison 1), as the certainty of evidence is very low. The two studies provided conflicting results, with one study showing benefit (mean difference (MD) -24.01 days, 95% confidence interval (CI) -35.65 to -12.37; 19 participants), whilst the other reported no difference. It is also unclear whether TNPWT has any effect on the proportion of wounds healed by 30 days (risk ratio (RR) 3.60, 95% CI 0.49 to 26.54; 19 participants, 1 study; very low-certainty evidence). Limited data were available for our secondary outcomes time to return to normal daily activities and recurrence rate; we do not know whether TNPWT has any effect on these outcomes.
   Lietofix cream may increase the proportion of wounds that heal by 30 days compared with an iodine dressing (comparison 4; RR 8.06, 95% CI 1.05 to 61.68; 205 participants, 1 study; low-certainty evidence). The study did not provide data on time to wound healing.
   We do not know whether hydrogel dressings reduce time to wound healing compared with wound cleaning with 10% povidone iodine (comparison 5; MD -24.54 days, 95% CI -47.72 to -1.36; 31 participants, 1 study; very low-certainty evidence). The study did not provide data on the proportion of wounds healed. It is unclear whether hydrogel dressings have any effect on adverse effects as the certainty of the evidence is very low.
   Platelet-rich plasma may reduce time to wound healing compared with sterile absorbent gauze (comparison 6; MD -19.63 days, 95% CI -34.69 to -4.57; 210 participants, 2 studies; low-certainty evidence). No studies provided data on the proportion of wounds healed. Plateletrich plasma may reduce time to return to normal daily activities (MD -15.49, 95% CI -28.95 to -2.02; 210 participants, 2 studies; low-certainty evidence).
   Zinc oxide mesh may make little or no difference to time to wound heating compared with placebo (comparison 2; median 54 days in the zinc oxide mesh group versus 62 days in the placebo mesh group; low-certainty evidence). We do not know whether zinc oxide mesh has an effect on the proportion of wounds healed by 30 days as the certainty of the evidence is very low (RR 2.35, 95% CI 0.49 to 11.23).
   It is unclear whether gentamicin-impregnated collagen sponge reduces time to wound healing compared with no dressing (comparison 7; MD -1.40 days, 95% CI -5.05 to 2.25; 50 participants, 1 study; very tow-certainty evidence). The study did not provide data on the proportion of wounds healed.
   Dialkylcarbamoyl chloride (DACC)-coated dressings may make little or no difference to time to wound healing compared with alginate dressings (comparison 8; median 69 (95% CI 62 to 72) days in the DACC group versus 71 (95% CI 69 to 85) days in the alginate group; 1 study, 246 participants; low-certainty evidence).
   One study compared a polyurethane foam hydrophilic dressing with an alginate dressing (comparison 3) whilst another study compared a hydrocolloid dressing with an iodine dressing (comparison 9). It is unclear whether either intervention has any effect on time to wound healing as the certainty of evidence is very low.
   Authors' conclusions
   At present, the evidence that any of the dressings or topical agents contained in this review have a benefit on time to wound heating, the proportion of wounds that heal at a specific time point or on any of the secondary outcomes of our review ranges from low certainty to very low certainty. There is low-certainty evidence on the benefit on wound healing of platelet-rich plasma from two studies and of Lietofix cream and hydrogel dressings from single studies. Further studies are required to investigate these interventions further.
C1 [Herrod, Philip J.; Hardy, Edward J.] Royal Derby Hosp, Dept Surg, Derby, England.
   [Doleman, Brett; Williams, John P.] Univ Nottingham, Sch Med, Dept Surg & Anaesthesia, Div Med Sci & Grad Entry Med, Derby, England.
   [Hardy, Paul; Maloney, Trevor] Royal Derby Hosp, Dept Tissue Viabil, Derby, England.
   [Lund, Jon N.] Univ Nottingham, Sch Med, Div Hlth Sci, Derby, England.
C3 University of Nottingham; University of Nottingham; University of
   Nottingham; University of Nottingham
RP Herrod, PJ (通讯作者)，Royal Derby Hosp, Dept Surg, Derby, England.
EM pherrod@nhs.net
RI Lund, Jonathan/K-6631-2019
OI Lund, Jonathan/0000-0001-5195-2181; Doleman, Brett/0000-0003-4707-4755;
   Herrod, Philip/0000-0002-6839-3897
FU National Institute for Health Research (NIHR), UK; National Institute
   for Health Research, via Cochrane Infrastructure funding; National
   Institute for Health Research [ACF-2020-12-004] Funding Source:
   researchfish
FX National Institute for Health Research (NIHR), UK This project was
   supported by the National Institute for Health Research, via Cochrane
   Infrastructure funding to Cochrane Wounds. The views and opinions
   expressed are those of the authors and not necessarily those of the
   NIHR, NHS or the Department of Health and Social Care.
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NR 56
TC 18
Z9 19
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2022
IS 5
AR CD013439
DI 10.1002/14651858.CD013439.pub2
PG 72
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1S5YF
UT WOS:000804126100021
PM 35593897
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Rojas, SV
   Junghans, S
   Fox, H
   Lazouski, K
   Schramm, R
   Morshuis, M
   Gummert, JF
   Gross, J
AF Rojas, Sebastian, V
   Junghans, Simon
   Fox, Henrik
   Lazouski, Kanstantsin
   Schramm, Rene
   Morshuis, Michiel
   Gummert, Jan F.
   Gross, Justus
TI Bacteriophage-Enriched Galenic for Intrapericardial Ventricular Assist
   Device Infection
SO ANTIBIOTICS-BASEL
LA English
DT Article
DE LVAD; left ventricular assist device; infections; bacteria;
   bacteriophages; negative pressure wound therapy; NPWT
AB We report a case of severe outflow graft infection following left ventricular assist device (LVAD) implantation. A 51-year old male LVAD patient was readmitted to our hospital presenting signs of systemic infection. One year previously, LVAD implantation (HeartMate3, Abbott, Chicago, IL, USA) with concomitant patent foramen ovale closure had been performed in the context of end-stage heart failure due to dilative cardiomyopathy (INTERMACS III). The indication for LVAD-therapy was bridge-to-candidacy, since the patient did not instantly fulfill all criteria for cardiac transplantation. At admission, a PET-CT scan unveiled fluid accumulation, encircling the outflow-graft prosthesis (SUVmax 10.5) with contrast-enhancement involving the intrathoracic driveline (SUVmax 11.2). Since cardiac transplantation was not feasible, the patient underwent surgical revision. In the first step, redo sternotomy was performed with local debridement, including jet lavage. Intraoperative swabs confirmed bacterial infection with staphylococcus aureus. Following this, the patient underwent negative pressure wound therapy (NPWT) with instillation using the V.A.C. VERAFLO system (KCI-3M, San Antonio, TX, USA) for a total of 19 days. Due to the severity of infection, local bacteriophage application was performed within the wound closure. In order to concentrate phage therapy at the infection site, phages were applied using a novel semi-fluid galenic. After wound closure, the patient was discharged with an uneventful course. A control PET-CT scan 3 months after discharge showed a significant decrease in infection (outflow graft: SUVmax 7.2, intrathoracic driveline: SUVmax 3.0) correlated with contrast enhancement. Bacterial infection of intrathoracic VAD components represents a severe and potentially life-threatening complication. If cardiac transplantation is not feasible, complex wound management strategies are required. Local bacteriophage therapy might be a promising addition to already established therapeutical options. In order to improve bacteriophage retention at the wound site, application of a viscous galenic might be beneficial.
C1 [Rojas, Sebastian, V; Fox, Henrik; Lazouski, Kanstantsin; Schramm, Rene; Morshuis, Michiel; Gummert, Jan F.] Ruhr Univ Bochum, Univ Hosp, Heart & Diabet Ctr North Rhine Westphalia, Clin Thorac & Cardiovasc Surg, D-32545 Bad Oeynhausen, Germany.
   [Junghans, Simon] G Pohl Boskamp GmbH & Co KG, D-25551 Hohenlockstedt, Germany.
   [Gross, Justus] Rostock Univ, Dept Gen Visceral Vasc & Transplantat Surg, Med Ctr, D-18057 Rostock, Germany.
C3 Ruhr University Bochum; University of Rostock
RP Rojas, SV (通讯作者)，Ruhr Univ Bochum, Univ Hosp, Heart & Diabet Ctr North Rhine Westphalia, Clin Thorac & Cardiovasc Surg, D-32545 Bad Oeynhausen, Germany.
EM srojashernandez@hdz-nrw.de; s-junghans@web.de; hfox@hdz-nrw.de;
   klazouski@hdz-nrw.de; rschramm@hdz-nrw.de; mmorshuis@hdz-nrw.de;
   jgummert@hdz-nrw.de; justus.gross@med.uni-rostock.de
RI Fox, Henrik/AAG-9968-2019; Rojas, Sebastian/AFR-1536-2022
OI Fox, Henrik/0000-0002-2187-8715; Gross, Justus/0000-0002-3281-7512;
   Rojas, Sebastian/0000-0002-9505-1358; Gummert, Jan/0000-0002-6956-9110
CR Bernhardt AM, 2020, J CRIT CARE, V56, P106, DOI 10.1016/j.jcrc.2019.12.014
   Hanff TC, 2019, CURR HEART FAIL REP, V16, P168, DOI 10.1007/s11897-019-00438-x
   Krzelj K, 2022, THORAC CARDIOV SURG, V70, P493, DOI 10.1055/s-0041-1731823
   Mulzer J, 2020, EUR J CARDIO-THORAC, V57, P1003, DOI 10.1093/ejcts/ezz295
   Pienta M, 2021, JTCVS OPEN, V8, DOI 10.1016/j.xjon.2021.08.005
   Rojas SV, 2016, CURR OPIN CARDIOL, V31, P308, DOI 10.1097/HCO.0000000000000290
   Rubalskii E, 2020, ANTIBIOTICS-BASEL, V9, DOI 10.3390/antibiotics9050232
   Rubalskii E, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-38318-4
   Shore S, 2022, J HEART LUNG TRANSPL, V41, P1, DOI 10.1016/j.healun.2021.10.006
   Tkhilaishvili T, 2022, J HEART LUNG TRANSPL, V41, P551, DOI 10.1016/j.healun.2022.01.018
   Tkhilaishvili T, 2021, J INFECTION, V83, pE1, DOI 10.1016/j.jinf.2021.05.027
   Yost G, 2021, ASAIO J, V67, P642, DOI 10.1097/MAT.0000000000001287
NR 12
TC 16
Z9 18
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2079-6382
J9 ANTIBIOTICS-BASEL
JI Antibiotics-Basel
PD MAY
PY 2022
VL 11
IS 5
AR 602
DI 10.3390/antibiotics11050602
PG 6
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA 1T6ZU
UT WOS:000804879300001
PM 35625246
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Reimer, S
   Lock, JF
   Flemming, S
   Weich, A
   Widder, A
   Plassmeier, L
   Doering, A
   Hering, I
   Hankir, MK
   Meining, A
   Germer, CT
   Groneberg, K
   Seyfried, F
AF Reimer, Stanislaus
   Lock, Johan F.
   Flemming, Sven
   Weich, Alexander
   Widder, Anna
   Plassmeier, Lars
   Doering, Anna
   Hering, Ilona
   Hankir, Mohammed K.
   Meining, Alexander
   Germer, Christoph-Thomas
   Groneberg, Kaja
   Seyfried, Florian
TI Endoscopic Management of Large Leakages After Upper Gastrointestinal
   Surgery
SO FRONTIERS IN SURGERY
LA English
DT Article
DE anastomotic leakage; endoluminal; vacuum-assisted closure; negative
   pressure; endoscopic
ID ENDOLUMINAL VACUUM THERAPY; ESOPHAGECTOMY; DEFECTS; CLOSURE
AB Background: Endoscopic vacuum therapy (EVT) is an evidence-based option to treat anastomotic leakages of the upper gastrointestinal (GI) tract, but the technical challenges and clinical outcomes of patients with large defects remain poorly described. Methods: All patients with leakages of the upper GI tract that were treated with endoscopic negative pressure therapy at our institution from 2012-2021 were analyzed. Patients with large defects (> 30 mm) as an indicator of complex treatment were compared to patients with smaller defects (control group). Results: Ninety-two patients with postoperative anastomotic or staplerline leakages were identified, of whom 20 (21.7%) had large defects. Compared to the control group, these patients required prolonged therapy (42 vs. 14 days, p < 0.001) and hospital stay (63 vs. 26 days, p < 0.001) and developed significantly more septic complications (40 vs. 17.6%, p = 0.027.) which often necessitated additional endoscopic and/or surgical/interventional treatments (45 vs. 17.4%, p = 0.007.) Nevertheless, a resolution of leakages was achieved in 80% of patients with large defects, which was similar compared to the control group (p = 0.42). Multiple leakages, especially on the opposite side, along with other local unfavorable conditions, such as foreign material mass, limited access to the defect or extensive necrosis occurred significantly more often in cases with large defects (p < 0.001). Conclusions: Overall, our study confirms that EVT for leakages even from large defects of the upper GI tract is feasible in most cases but comes with significant technical challenges.
C1 [Reimer, Stanislaus; Weich, Alexander; Meining, Alexander; Groneberg, Kaja] Univ Hosp Wurzburg, Dept Gastroenterol, Wurzburg, Germany.
   [Lock, Johan F.; Flemming, Sven; Widder, Anna; Plassmeier, Lars; Doering, Anna; Hering, Ilona; Hankir, Mohammed K.; Germer, Christoph-Thomas; Seyfried, Florian] Univ Hosp Wurzburg, Dept Gen Visceral Transplant Vasc & Pediat Surg, Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg
RP Seyfried, F (通讯作者)，Univ Hosp Wurzburg, Dept Gen Visceral Transplant Vasc & Pediat Surg, Wurzburg, Germany.
EM Seyfried_F@ukw.de
RI Lock, Johan/AAA-8114-2020; Weich, Alexander/ACW-1676-2022; Flemming,
   Sven/AAA-9950-2020; Hankir, Mohammed/IZD-4807-2023
OI Lock, Johan/0000-0002-9007-3937; Meining, Alexander/0009-0001-3773-138X
CR Åkesson O, 2022, SURG ENDOSC, V36, P1903, DOI 10.1007/s00464-021-08472-4
   Gubler C, 2019, DIS ESOPHAGUS, V32, DOI 10.1093/dote/doy126
   de Moura DTH, 2019, WORLD J GASTRO ENDOS, V11, P329, DOI 10.4253/wjge.v11.i5.329
   Jung DH, 2021, J CLIN MED, V10, DOI 10.3390/jcm10112346
   Kelm M, 2017, INT J SURG CASE REP, V41, P401, DOI 10.1016/j.ijscr.2017.11.022
   Kuehn F, 2016, J GASTROINTEST SURG, V20, P237, DOI 10.1007/s11605-015-3044-4
   Laukoetter MG, 2017, SURG ENDOSC, V31, P2687, DOI 10.1007/s00464-016-5265-3
   Lock JF, 2021, WORLD J GASTROENTERO, V27, P1841, DOI 10.3748/wjg.v27.i16.1841
   Loske G, 2022, SURG ENDOSC, V36, P2208, DOI 10.1007/s00464-021-08933-w
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Müller PC, 2021, ANN SURG, V274, P751, DOI 10.1097/SLA.0000000000005125
   Neumann PA, 2017, ENDOSCOPY, V49, P498, DOI 10.1055/s-0042-123188
   Newton NJ, 2017, DIS ESOPHAGUS, V30, DOI 10.1111/dote.12531
   Noble F, 2012, J GASTROINTEST SURG, V16, P1083, DOI 10.1007/s11605-012-1867-9
   Schniewind B, 2013, SURG ENDOSC, V27, P3883, DOI 10.1007/s00464-013-2998-0
   Schorsch T, 2013, SURG ENDOSC, V27, P2040, DOI 10.1007/s00464-012-2707-4
NR 16
TC 6
Z9 8
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD MAY 9
PY 2022
VL 9
AR 885244
DI 10.3389/fsurg.2022.885244
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 1T8CS
UT WOS:000804954600001
PM 35615653
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Al, SA
   Asha, W
   Asha, A
   Abou Chaar, MK
   Jarrar, A
   Qawasmi, M
   Salameh, H
   Alsaadi, N
AF Abdel Al, S.
   Asha, W.
   Asha, A.
   Abou Chaar, M. K.
   Jarrar, A.
   Qawasmi, M.
   Salameh, H.
   Alsaadi, N.
TI Chemotherapy extravasation injuries beyond the immediate stage: A series
   of 15 cases treated according to a preset surgical algorithm based on
   time of presentation
SO HAND SURGERY & REHABILITATION
LA English
DT Article
DE Chemotherapy extravasation; Chemotherapy complications; Post-cancer
   reconstruction; Hand injury
ID SUBCUTANEOUS WASH-OUT; CYTOSTATIC AGENTS; MANAGEMENT; PREVENTION;
   DOXORUBICIN; DORSUM; ULCERS
AB Chemotherapy extravasation can cause severe harm. There is a lack of evidence-based standardization on the surgical management of such injuries beyond the immediate stage. In an algorithm connecting presentation time post-injury with surgical treatment could help standardize future treatment. This study prospectively validated a preset standardized surgical algorithm based on presentation time in a consecutive series between October 2017 and October 2020. Chemotherapeutic agent, site and extent of injury, type of surgery and outcome at a minimum of 6 months' follow-up were collected. Seven thousand six hundred twelve individuals received chemotherapy during that period; 15 patients suffered extravasation injuries, 2 of whom were referred from outside our hospital. This algorithm distinguished: A) beyond the immediate stage and up to 2 days, treated with saline subcutaneous washout (SCWO) and vacuum-assisted closure (VAC) dressing; B) 2 to 5 days, open surgical decompression and VAC dressing; C) 5 to 10 days, non-operative management with surveillance; and D) more than 10 days, radical necrotic excision with or without VAC dressing and tissue reconstruction. In 2 patients in Group A and 3 patients in Group B, all vesicant symptoms resolved. Five of the 6 patients in Group C (3 vesicant, 3 non-vesicant) did not progress into necrosis or infection, and 1 case of vesicant extravasation progressed to a localized ulcer beyond this period and, as surgery was refused, led to a chronic ulcer with stiffness; 2 cases of non-vesicant extravasation developed a recall phenomenon but resolved after the third cycle. Of the 4 patients in Group D, all vesicant, 2 were treated with no complications, 1 had complex regional pain syndrome (CRPS) due to late presentation, and 1, referred with necrotizing fasciitis, underwent above-elbow amputation but died due to septic shock. This study demonstrated a uniform surgical approach in a series of 15 cases; larger studies are still needed to validate the efficacy of this protocol in reducing morbidity. (C) 2022 SFCM. Published by Elsevier Masson SAS. All rights reserved.
C1 [Abdel Al, S.; Qawasmi, M.] King Hussein Canc Ctr, Dept Orthoped Oncol Hand & Microsurg, Queen Rania Al Abdulla St 202, Amman 11941, Jordan.
   [Asha, W.; Asha, A.; Abou Chaar, M. K.; Jarrar, A.; Salameh, H.; Alsaadi, N.] King Hussein Canc Ctr, Dept Clin Res, Queen Rania Al Abdulla St 202, Amman 11941, Jordan.
C3 King Hussein Cancer Center; King Hussein Cancer Center
RP Al, SA (通讯作者)，King Hussein Canc Ctr, Dept Orthoped Oncol Hand & Microsurg, Queen Rania Al Abdulla St 202, Amman 11941, Jordan.
EM S.AbdelAlDa.10670@khcc.jo
RI ; Abou Chaar, Mohamad K/AAB-5494-2021; Abdel Al, Samer/ABE-2728-2021;
   Asha, Wafa/OMM-4477-2025
OI Salameh, Hamza/0000-0002-0022-5707; Abou Chaar, Mohamad
   K/0000-0002-9584-2184; Abdel Al, Samer/0000-0001-8354-3323; Alsaadi,
   Nijmeh/0000-0002-4290-0539; 
CR Boulanger J, 2015, SUPPORT CARE CANCER, V23, P1459, DOI 10.1007/s00520-015-2635-7
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NR 31
TC 3
Z9 4
U1 1
U2 2
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 2468-1229
EI 2468-1210
J9 HAND SURG REHABIL
JI Hand Surg. Rehabil.
PD JUN
PY 2022
VL 41
IS 3
BP 391
EP 399
DI 10.1016/j.hansur.2022.02.009
EA MAY 2022
PG 9
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 1T8WJ
UT WOS:000805005700016
PM 35283338
DA 2026-07-24
ER
PT J
AU Rajabaleyan, P
   Michelsen, J
   Holst, UT
   Möller, S
   Toft, P
   Luxhoi, J
   Buyukuslu, M
   Bohm, AM
   Borly, L
   Sandblom, G
   Kobborg, M
   Poulsen, KA
   Love, US
   Ovesen, S
   Solling, CG
   Sondergaard, BM
   Lomholt, ML
   Moller, DR
   Qvist, N
   Ellebæk, MB
AF Rajabaleyan, Pooya
   Michelsen, Jens
   Tange Holst, Uffe
   Moller, Soren
   Toft, Palle
   Luxhoi, Jan
   Buyukuslu, Musa
   Bohm, Aske Mathias
   Borly, Lars
   Sandblom, Gabriel
   Kobborg, Martin
   Aagaard Poulsen, Kristian
   Schou Love, Uffe
   Ovesen, Sophie
   Grant Solling, Christoffer
   Morch Sondergaard, Birgitte
   Lund Lomholt, Marianne
   Ritz Moller, Dorthe
   Qvist, Niels
   Bremholm Ellebaek, Mark
CA VACOR Study Grp
TI Vacuum-assisted closure versus on-demand relaparotomy in patients with
   secondary peritonitis-the VACOR trial: protocol for a randomised
   controlled trial
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Secondary peritonitis; Faecal peritonitis; Vacuum-assisted closure;
   Primary abdominal closure; Relaparotomy on-demand
ID PRESSURE WOUND THERAPY; OPEN ABDOMEN; NEGATIVE-PRESSURE; POSTOPERATIVE
   PERITONITIS; PLANNED RELAPAROTOMY; ABDOMINAL SEPSIS; MANAGEMENT;
   CLASSIFICATION; PREDICTORS; MORBIDITY
AB Background Secondary peritonitis is a severe condition with a 20-32% reported mortality. The accepted treatment modalities are vacuum-assisted closure (VAC) or primary closure with relaparotomy on-demand (ROD). However, no randomised controlled trial has been completed to compare the two methods potential benefits and disadvantages. Methods This study will be a randomised controlled multicentre trial, including patients aged 18 years or older with purulent or faecal peritonitis confined to at least two of the four abdominal quadrants originating from the small intestine, colon, or rectum. Randomisation will be web-based to either primary closure with ROD or VAC in blocks of 2, 4, and 6. The primary endpoint is peritonitis-related complications within 30 or 90 days and one year after index operation. Secondary outcomes are comprehensive complication index (CCI) and mortality after 30 or 90 days and one year; quality of life assessment by (SF-36) after three and 12 months, the development of incisional hernia after 12 months assessed by clinical examination and CT-scanning and healthcare resource utilisation. With an estimated superiority of 15% in the primary outcome for VAC, 340 patients must be included. Hospitals in Denmark and Europe will be invited to participate. Discussion There is no robust evidence for choosing either open abdomen with VAC treatment or primary closure with relaparotomy on-demand in patients with secondary peritonitis. The present study has the potential to answer this important clinical question.
C1 [Rajabaleyan, Pooya; Tange Holst, Uffe; Aagaard Poulsen, Kristian; Qvist, Niels; Bremholm Ellebaek, Mark] Odense Univ Hosp, Res Unit Surg, Odense, Denmark.
   [Michelsen, Jens; Toft, Palle] Odense Univ Hosp, Res Unit Anaesthesiol, Odense, Denmark.
   [Moller, Soren] Odense Univ Hosp, Open Patient Data Explorat Network, OPEN, Odense, Denmark.
   [Moller, Soren] Univ Southern Denmark, Dept Clin Res, Odense, Denmark.
   [Luxhoi, Jan; Buyukuslu, Musa] Hosp Southwest Jutland, Surg Dept, Esbjerg, Denmark.
   [Bohm, Aske Mathias; Borly, Lars] Holbaek Cent Hosp, Surg Dept, Holbaek, Denmark.
   [Sandblom, Gabriel] Karolinska Inst, Stockholm, Sweden.
   [Kobborg, Martin] Kolding Cty Hosp, Surg Dept, Kolding, Denmark.
   [Schou Love, Uffe; Ovesen, Sophie; Grant Solling, Christoffer; Morch Sondergaard, Birgitte] Viborg Hosp, Surg Dept, Viborg, Denmark.
   [Lund Lomholt, Marianne; Ritz Moller, Dorthe] Aarhus Univ Hosp, Surg Dept, Aarhus, Denmark.
   [Rajabaleyan, Pooya; Michelsen, Jens; Tange Holst, Uffe; Toft, Palle; Aagaard Poulsen, Kristian; Qvist, Niels; Bremholm Ellebaek, Mark] Univ Southern Denmark, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Odense University Hospital; University of Southern Denmark;
   Holbaek Hospital; Karolinska Institutet; Kolding Hospital; Aarhus
   University; Viborg City Hospital; Aarhus University; University of
   Southern Denmark
RP Rajabaleyan, P (通讯作者)，Odense Univ Hosp, Res Unit Surg, Odense, Denmark.
EM Pooya.rajabaleyan@rsyd.dk
RI Michelsen, Jens/QAY-7340-2026; Ellebaek, Mark Bremholm/ADW-1803-2022;
   Möller, Sören/X-8738-2019
OI Michelsen, Jens/0000-0002-1244-6072; Løve, Uffe
   Schou/0000-0002-2409-0499; Ellebaek, Mark Bremholm/0000-0001-6550-7505;
   Rajabaleyan, Pooya/0000-0002-6882-9427; Toft, Palle/0000-0002-3188-449X;
   Sølling, Christoffer/0000-0003-0721-926X; Möller,
   Sören/0000-0003-0858-4269
FU University of Southern Denmark; Region of Southern Denmark; Novo Nordisk
   Foundation [NNF19OC0058637, A301]; University of Southern Denmark,
   Campusvej, Odense M, Denmark; Region of Southern Denmark, Damhaven,
   Vejle, Denmark; Novo Nordisk Foundation, Tuborg Havnevej, Hellerup,
   Denmark
FX The study is funded by the University of Southern Denmark, Region of
   Southern Denmark, and Novo Nordisk Foundation (Grant Nos.
   NNF19OC0058637, NNF19OC0058637, A301). Trial Sponsor: University of
   Southern Denmark, Campusvej 55, 5230 Odense M, Denmark, Email:
   sdu@sdu.dk, Region of Southern Denmark, Damhaven 12, 7100 Vejle,
   Denmark, and Novo Nordisk Foundation, Tuborg Havnevej 19, 2900 Hellerup,
   Denmark, Email: info@novonordiskfonden.dk.The sponsors have no influence
   on the study design or interpretation of data.
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NR 64
TC 8
Z9 19
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD MAY 26
PY 2022
VL 17
IS 1
AR 25
DI 10.1186/s13017-022-00427-x
PG 13
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 1U7WQ
UT WOS:000805618500003
PM 35619144
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Valenzuela, MM
   Averkamp, BJ
   Odum, SM
   Rowe, TM
   Fehring, TK
AF Valenzuela, Michael M.
   Averkamp, Benjamin J.
   Odum, Susan M.
   Rowe, Taylor M.
   Fehring, Thomas K.
TI Polymicrobial Colonization of Prosthetic Joint Infections Treated With
   Open Wound Management
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article; Proceedings Paper
CT Meeting of the Hip-Society
CY OCT, 2021
CL Washington, DC
SP Hip Soc
DE prosthetic joint infection; open wound management; negative pressure
   wound therapy; polymicrobial; fungal
ID TOTAL KNEE ARTHROPLASTY; 2-STAGE EXCHANGE; HIP; THERAPY; DEBRIDEMENT;
   IRRIGATION; RETENTION; FAILURE
AB Background: Open wound management in prosthetic joint infection (PJI) patients has been used in problematic dehisced wounds hoping to stimulate granulation tissue and closure. However, infections that start as a monomicrobial PJI can become polymicrobial with resultant worse outcomes following open wound management. This study assessed the relationship between open wound management and the development of polymicrobial periprosthetic joint infections.
   Methods: We reviewed patients referred with a synovial cutaneous fistula. Patients with an open wound measuring less than 2 cm and less than two weeks of open wound management were excluded. Variables included original organisms cultured, type and length of open wound management, and organisms cultured at the time of revision infection surgery.
   Results: Of the 65 patients with a previous monomicrobial infection treated with open wound management, 22/65 (34%) progressed to a polymicrobial infection. Thirty (46%) wounds were packed open with gauze, 20 (31%) were managed with negative pressure wound therapy, and 15 (23%) had surface dressings only. Of the 22 patients who converted to a polymicrobial infection, only 10 (45%) were infection free at follow-up. In contrast, 30 of 43 patients (70%) whose infections remained monomicrobial were infection free at follow-up.
   Conclusion: Open wound management can lead to conversion from a monomicrobial to a polymicrobial PJI, a rate of 34% in this series. Open prosthetic wound management should be discontinued for a fear of converting a monomicrobial infection to a difficult to treat polymicrobial infection. Surgeons must be prudent in the use of open wound management. (C) 2022 Elsevier Inc. All rights reserved.
C1 [Valenzuela, Michael M.; Odum, Susan M.; Rowe, Taylor M.] OrthoCarolina Res Inst, Charlotte, NC USA.
   [Averkamp, Benjamin J.; Odum, Susan M.; Fehring, Thomas K.] Atrium Hlth Musculoskeletal Inst, Dept Orthopaed Surg, Charlotte, NC USA.
   [Fehring, Thomas K.] OrthoCarolina Hip & Knee Ctr, Charlotte, NC USA.
RP Fehring, TK (通讯作者)，OrthoCarolina, 2001 Vail Ave Suite 200A, Charlotte, NC 28207 USA.
OI Valenzuela, Michael/0000-0002-5092-4020
CR Ailaney N, 2021, J ARTHROPLASTY, V36, P2402, DOI 10.1016/j.arth.2020.11.039
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NR 32
TC 9
Z9 12
U1 0
U2 11
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD JUL
PY 2022
VL 37
IS 7
SU S
BP S653
EP S656
DI 10.1016/j.arth.2022.03.016
EA MAY 2022
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics
GA 1X6FL
UT WOS:000807548000048
PM 35283231
OA Bronze
DA 2026-07-24
ER
PT J
AU Klein, RJ
AF Klein, Robert J.
TI Using Negative Pressure Wound Therapy With Instillation and Dwell Time
   to Create a Path to Closure for Older Patients With Chronic Wounds: A
   Retrospective Case Series
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time;
   chronic wound; podiatry; limb salvage; case series
ID BED PREPARATION
AB BACKGROUND: Chronic podiatric wounds are common causes of morbidity and mortality in older patients. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been recommended in wounds with high levels of exudate, contaminated wounds, and wounds in which healing progression has stalled. PURPOSE: This retrospective case series describes the use of NPWTi-d to prepare 4 chronic wounds for closure in older patients with multiple comorbidities. METHODS: Patients (N = 4) ranged in age from 65 to 95 years and had wounds present for at least 90 days. Previous treatments included conventional NPWT and debridement. NPWTi-d consisted of instillation of 10 to 20 mL normal saline, dwell time for 1 minute, followed by 3-hour cycles of -125 mm Hg. Antibiotics were administered as needed. Wounds included a 210-day Wagner grade 3 diabetic foot ulcer (3.2 x 1.8 x 0.3 cm(3)), a 90-day dehisced wound (9.5 x 2.6 x 0.4 cm(3)), a 300-day neuropathic ulcer (0.7 x 0.5 x 2.1 cm(3)), and a 150-day Wagner grade 2 diabetic foot ulcer (4.5 x 3.3 x 0.9 cm(3)). NPWTi-d was applied for 3 to 33 days, when care was transitioned to advanced wound dressings. RESULTS: All 4 wounds responded positively to therapy, exhibiting reduced slough, growing granulation tissue, and size reduction. Closure was achieved in all cases. CONCLUSION: In these 4 patients, NPWTi-d, used as part of a treatment regimen including debridement, antibiotics, and advanced wound dressings, was effective in creating an environment that promoted wound healing and prepared the wounds for eventual closure.
C1 [Klein, Robert J.] PRISMA Hlth Upstate, Wound Care, Greenville, SC USA.
C3 Prisma Health
RP Klein, RJ (通讯作者)，VHA Wound Healing & Hyperbar Oxygen Ctr, 200 Patewood Dr,Suite C300, Greenville, SC 29615 USA.
EM robklein63@gmail.com
CR Ahmed AF, 2012, J ADV RES, V3, P109, DOI 10.1016/j.jare.2011.05.004
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NR 13
TC 2
Z9 4
U1 4
U2 11
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD FEB
PY 2022
VL 68
IS 2
BP 16
EP 21
DI 10.25270/wmp.2022.2.1621
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA 2B9QA
UT WOS:000810514500001
DA 2026-07-24
ER
PT J
AU Tian, C
   Xu, KH
   Zhao, YN
   Li, YH
   Wu, KP
   Jiao, DC
   Han, XW
AF Tian, Chuan
   Xu, Kaihao
   Zhao, Yanan
   Li, Yahua
   Wu, Kunpeng
   Jiao, Dechao
   Han, Xinwei
TI Vacuum sealing drainage combined with naso-intestinal and gastric
   decompression tubes for the treatment of esophagogastrostomy neck
   fistula
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Vacuum sealing drainage; Nutritional tube; Gastric decompression tube;
   Esophagogastrostomy; Fistula
ID ANASTOMOTIC LEAK; RISK-FACTORS; STENT; ESOPHAGECTOMY; VANCOMYCIN;
   STRICTURE
AB Objective To evaluate the clinical results of the vacuum sealing drainage (VSD) combined with a naso-intestinal nutritional tube (NIT) and a gastric decompression tube (GDT) for the treatment of esophagogastrostomy neck fistula (ENF). Methods From January 2018 to October 2020, twenty patients (13 men and 7 women, ages 46-72) with ENF secondary to esophagogastrostomy were treated with VSD combined with NIT and GDT. Technical and clinical success rates, the incidence of early/late complications, the time of fistula closure (TFC) and therapy-related indicators were analyzed. The Karnofsky score and Eastern Cooperative Oncology Group (ECOG) score were compared before and after triple treatment. Results Technical and clinical success rates were 100% and 85%, respectively. Early complications occurred in 5/20 (25%) patients, and late complications occurred in 8/20 (40%) patients. The median TFC was 18 days (range 10-23). All therapy-related indicators were normalized posttreatment. The Karnofsky score and ECOG score after treatment were significantly different compared with pretreatment scores (p < 0.001). Conclusion VSD combined with NIT and GDT is a safe and effective strategy for ENF, while severe strictures warrant further research.
C1 [Tian, Chuan; Xu, Kaihao; Zhao, Yanan; Li, Yahua; Wu, Kunpeng; Jiao, Dechao; Han, Xinwei] Zhengzhou Univ, Affiliated Hosp 1, Dept Intervent Radiol, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
C3 Zhengzhou University
RP Jiao, DC; Han, XW (通讯作者)，Zhengzhou Univ, Affiliated Hosp 1, Dept Intervent Radiol, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
EM jiaodechao007@126.com; fcchanxw@zzu.edu.cn
RI Wu, Kunpeng/AEB-7274-2022; Zhao, Yanan/KHY-2872-2024; han,
   wei/ABG-2691-2021; Dechao, Jiao/ABH-1680-2021
OI Wu, Kunpeng/0000-0001-6408-8927; 
FU Young and Middle-aged Health Science and Technology Innovation Talent
   Project of Henan Province in 2020 [yxkc2020037]; Youth Project of Henan
   Provincial Health Commission and Ministry Jointly Support [sb201902014]
FX This work was supported by the Young and Middle-aged Health Science and
   Technology Innovation Talent Project of Henan Province in 2020
   (yxkc2020037) and the Youth Project of Henan Provincial Health
   Commission and Ministry Jointly Support (sb201902014).
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NR 33
TC 6
Z9 6
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD JUN 13
PY 2022
VL 17
IS 1
AR 153
DI 10.1186/s13019-022-01883-x
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 2C2DL
UT WOS:000810685000002
PM 35698141
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhao, Y
   Zhao, Y
   Zhang, LQ
   Feng, GD
AF Zhao, Yong
   Zhao, Yang
   Zhang, Li-Qin
   Feng, Guo-Dong
TI Postoperative infection of the skull base surgical site due to
   suppurative parotitis: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Postoperative infection; Lateral skull base; Suppurative parotitis;
   Vacuum sealing drainage; Two-stage surgery; Case report
ID PHEOCHROMOCYTOMA; SURGERY
AB BACKGROUND Paraganglioma occurring at the lateral skull base is a rare tumor. Surgery is the primary treatment of benign paragangliomas. Postoperative infection of the surgical site at the lateral skull base is very dangerous and hard to manage. CASE SUMMARY A 30-year-old man with a 1-year history of left-side progressive hearing loss, tinnitus, facial palsy, and choking failed conventional treatment and is the focus of this case report. Imaging revealed a mass around the left jugular foramen that was approximately 47 mm x 38 mm x 34 mm in size and had eroded the bone of the vertebral and horizontal segments of the internal carotid artery. The tumor breached the meninges and occupied the cerebella pontine region. A two-stage surgery was designed for the resection of the mass. In the first-stage, the epidural portion of the mass was removed. The abdominal fat and the temporal muscle flap were transposed within the surgical site. The surgery was successful; however, 25 d after surgery, he developed suppurative parotitis, and the infection spread to the surgical site at the skull base. Broad-spectrum antibiotics were used, and debridement was deployed. After that, the wound was cleaned daily. Five months after the first-stage surgery, the wound was still unclosed, and there was intermittent purulent exudation within the surgical site. vacuum sealing drainage (VSD) was used, and the wound healed in a month. One year after the first surgery, the second-stage of the operation was performed to remove the intracranial portion of the tumor. Recurrence of the tumor was not detected after a 6-month follow-up. CONCLUSION After a lateral skull base surgery, suppurative parotitis can spread into the operative cavity leading to infection of the surgical site. VSD can help to effectively heal the infected wound. A two-stage surgical approach offers a safer option for removing the lateral skull base paraganglioma that involves the meninges.
C1 [Zhao, Yong; Zhao, Yang; Zhang, Li-Qin; Feng, Guo-Dong] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100730, Peoples R China.
   [Feng, Guo-Dong] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Shuaifuyuan Wangfujing, Beijing 100730, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Feng, GD (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Shuaifuyuan Wangfujing, Beijing 100730, Peoples R China.
EM ok_surgeon@163.com
RI Feng, Guodong/PJS-4356-2026
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NR 12
TC 0
Z9 1
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD MAY 26
PY 2022
VL 10
IS 15
BP 4991
EP 4997
DI 10.12998/wjcc.v10.i15.4991
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2E3MS
UT WOS:000812133700030
PM 35801038
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Yilmaz, M
   Thorn, A
   Sorensen, MS
   Jensen, CL
   Petersen, MM
AF Yilmaz, Mujgan
   Thorn, Andrea
   Sorensen, Michala Skovlund
   Jensen, Claus Lindkaer
   Petersen, Michael Mork
TI Effect of negative pressure wound therapy after surgical removal of
   deep-seated high-malignant soft tissue sarcomas of the extremities and
   trunk wall-study protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Sarcoma; Soft tissue sarcoma; Negative pressure wound therapy; Prevena
   (TM); Extremity; Trunk wall
ID RISK-FACTORS; COMPLICATION; HIP
AB Background: Sarcomas are a heterogeneous group of rare malignant tumors of mesenchymal origin in the musculoskeletal system. The main treatment is surgery often supplemented with pre-or postoperative radiotherapy.
   A retrospective study by Bedi et al. indicated that negative pressure wound therapy (NPWT) reduced the risk of postoperative wound complications in patients treated with preoperative radiation followed by surgical tumor removal of lower extremity soft tissue sarcomas (STS), and the use of NPWT was not associated with an increased risk of local recurrence. Previous studies have shown that NPWT can reduce postoperative complications. STS surgeries are a high-risk procedure concerning wound complications.
   Methods: Non-blinded single-center randomized controlled trial comparing NPWT versus conventional wound dressing and postoperative wound complications after surgical removal of deep-seated high-malignant STS of the extremities or trunk wall
   Sample-size calculation: 154 STS patients (80% risk of avoiding type II error, 5% risk of type I error, and an 80% wound complication risk)
   Block randomization of 8 into:
   Group A: Conventional wound dressing
   Group B: NPWT (PREVENA PLUS (TM) Incision Management System)
   Inclusion criteria: Surgery for a deep-seated STS of an extremity or the trunk wall
   Exclusion criteria: Age < 18 years, plastic surgery, low malignant/borderline STS, chemotherapy, preoperative radiotherapy, allergic/hypersensitive to acrylic adhesives or silver, unwilling/unable to provide informed consent, metastatic disease, and ischemic surgeries
   Primary study endpoints were set as major wound complications defined by O'Sullivan et al. as a secondary surgery under anesthesia for wound repairs and wound management without secondary surgery within 4 months postoperatively.
   Secondary study endpoints among others are Musculoskeletal Tumor Society Score (MSTS), Toronto Extremity Salvage Score (TESS), and European Quality of Life - 5 Dimensions (EQ-5D).
   Approval from the Scientific Ethical Committee and the Data Protection Agency has been obtained, and the study is registered at clinicaltrial.gov.
   This study did not apply for external funding.
   Discussion: Many new medical devices and technical solutions are currently being introduced, and even though some documentation regarding the use of NPWT, e.g., in joint replacement surgery exist, it is also important to seek documentation for this treatment principle in STS surgery.
C1 [Yilmaz, Mujgan; Thorn, Andrea; Sorensen, Michala Skovlund; Jensen, Claus Lindkaer; Petersen, Michael Mork] Univ Hosp Copenhagen, Rigshosp, Dept Orthoped Surg, Inge Lehmanns Vej 6, DK-2100 Copenhagen, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University Hospital
RP Yilmaz, M (通讯作者)，Univ Hosp Copenhagen, Rigshosp, Dept Orthoped Surg, Inge Lehmanns Vej 6, DK-2100 Copenhagen, Denmark.
EM yilmaz_mujgan@hotmail.com
OI Yilmaz, Müjgan/0000-0002-1822-0453; Petersen, Michael
   Mørk/0000-0002-2324-6420; Sørensen, Michala Skovlund/0000-0003-0123-2666
FU Rigshospitalets forskningspulje
FX The study is initiated by the coordinating responsible investigator.
   There has been granted a Ph.D. scholarship from Rigshospitalets
   forskningspulje (3 years) for conduction of this study (and 2 other
   STS-related projects), and the amount given in total is 2,040,000 DKK.
CR [Anonymous], 2018, ICMJE RECOMMENDATION
   [Anonymous], 2013, JAMA-J AM MED ASSOC, DOI DOI 10.1001/JAMA.2013.281053
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NR 22
TC 2
Z9 2
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUN 18
PY 2022
VL 23
IS 1
AR 507
DI 10.1186/s13063-022-06468-6
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 2F0XI
UT WOS:000812640500005
PM 35717239
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Qiu, L
   Wang, F
   Xu, Q
   Lin, ZL
   Lin, B
   Huang, M
   Wu, QY
AF Qiu, Lin
   Wang, Feng
   Xu, Qin
   Lin, Zhenlv
   Lin, Bo
   Huang, Meng
   Wu, Qiaoyi
TI Negative pressure wound therapy promotes healing and reduced pain in
   patients with acute suppurative mastitis
SO BMC WOMENS HEALTH
LA English
DT Article
DE Acute suppurative mastitis; Vacuum sealing drainage; Treatment
ID VACUUM SEALING DRAINAGE; ASSISTED CLOSURE; LARGE-AREA
AB Background The purpose of this study was to compare the outcomes of vacuum sealing drainage (VSD) and conventional incision and drainage (I&D) for treating acute suppurative mastitis. Methods Hospital medical records were searched for patients 20-50 years of age who were diagnosed with acute suppurative mastitis from January 2014 to December 2018, and treated with traditional I&D or VSD. Patients were divided into those treated with VSD and I&D, and outcomes including pain, healing time, length of hospital stay, and length of antibiotic course were compared between the groups. Pain was evaluated with a numeric rating scale from 0 (no pain) to 10 (most severe pain). Subgroup analysis of lactating women was also performed. Results There were 110 women who received traditional I&D, and 105 women that received VSD included. The 2 groups were similar with respect to age (31.1 +/- 4.8 vs. 29.9 +/- 4.4, p = 0.058), and disease characteristics. The median pain score of women who received VSD (5 [IQR 5-6]) was significantly less than that of women who received I&D (8 [IQR 7-8]) (p < 0.001). The time for healing was significantly less in women who received VSD (40 days [IQR 30-45 days]) compared to I&D (60 days [IQR 45-70 days]) (p < 0.001). The length of hospital say and the length of antibiotic treatment were similar between the 2 groups. Results were similar for lactating women. Conclusions VSD is effective for treating acute suppurative mastitis with reduced pain and shortening healing time.
C1 [Qiu, Lin; Lin, Zhenlv; Lin, Bo; Wu, Qiaoyi] Fujian Med Univ, Affiliated Hosp 1, Dept Trauma Ctr & Emergency Surg, 20 Chazhong Rd, Fujian 350004, Peoples R China.
   [Wang, Feng] Fujian Hosp Peoples Armed Police, Dept Outpatient Care, Fuzhou 350025, Peoples R China.
   [Xu, Qin] Fujian Canc Hosp, Dept Gynecol, Fuzhou 350014, Peoples R China.
   [Xu, Qin] Fujian Med Univ, Canc Hosp, Fuzhou 350014, Peoples R China.
   [Huang, Meng] Fujian Ctr Dis Control & Prevent, Fuzhou 350001, Peoples R China.
C3 Fujian Medical University; Fujian Medical University; Fujian Provincial
   Center for Disease Control & Prevention
RP Wu, QY (通讯作者)，Fujian Med Univ, Affiliated Hosp 1, Dept Trauma Ctr & Emergency Surg, 20 Chazhong Rd, Fujian 350004, Peoples R China.
EM qywu@fjmu.edu.cn
FU Science and Technology Innovation Joint Fund Project of Science and
   Technology Department of Fujian Province, China [2018Y9110]
FX This work was supported by a grant from Science and Technology
   Innovation Joint Fund Project of Science and Technology Department of
   Fujian Province, China (No. 2018Y9110). The Fund Project provided a
   crucial idea for the design of this study, and there was plenty of help
   available for the manuscript writing. There was no financial support of
   this study by commercial interests.
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NR 17
TC 6
Z9 8
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6874
J9 BMC WOMENS HEALTH
JI BMC Womens Health
PD JUN 18
PY 2022
VL 22
IS 1
AR 243
DI 10.1186/s12905-022-01785-z
PG 7
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology
GA 2F0ZM
UT WOS:000812646100004
PM 35717192
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sun, YW
   Li, L
   Zhang, ZH
AF Sun, Yan-Wei
   Li, Liang
   Zhang, Zhi-Hua
TI Antibiotic-loaded Bone Cement Combined with Vacuum-assisted Closure
   Facilitating Wound Healing in Wagner 3-4 Diabetic Foot Ulcers
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article; Early Access
DE antibiotic-loaded bone cement; diabetic foot ulcer; vacuum-assisted
   closure; wagner grade; wound
ID MANAGEMENT; THERAPY; PREVENTION
AB This study explored the clinical effectiveness of antibiotic-loaded bone cement (ALBC) combined with vacuum-assisted closure (VAC) on the treatment of Wagner 3-4 diabetic foot ulcers (DFUs). This is a retrospective study, including 32 patients with Wagner 3-4 DFUs who had undergone treatment between August 2019 and June 2021. Patient age, sex, Hemoglobin A1c (HbA1c), body mass index (BMI), ankle brachial index (ABI), white blood cells (WBC), C-reactive protein (CRP) levels, comorbidities and wound closure methods were recorded. Patients were divided into the study group and control group according to the treatment modality. Patients in the study group received the combination treatment of ALBC and VAC, while patients in the control group received single VAC treatment. Clinical endpoints were assessed and compared between the two groups, including wound complete healing time and complications after operation. All patients were followed-up 6 months postoperation. Results showed that the mean healing time of the study group (44.20 +/- 16.72 days) was shorter than that of the control group (64.00 +/- 29.85 days) (P < .05). The infection rate of the study group on the 10th day postoperation was lower than that of the control group (6.67%, 47.06%, P < .05). And there were no significant statistical differences between the two groups in terms of bleeding and necrosis complications postoperation (P = .603, P = .603). Based on the findings, we conclude that the application of ALBC combined with VAC can facilitate wound healing in Wagner 3-4 DFUs patients. It can help to control wound infections and shorten wound healing time.
C1 [Sun, Yan-Wei; Li, Liang] Zibo Cent Hosp, Dept Burns & Plast Surg, 54 Gong Qing Tuan Xi Rd, Zibo 255036, Shandong, Peoples R China.
   [Zhang, Zhi-Hua] Qingdao Univ, Dept Vasc Surg, Affiliated Qingdao Cent Hosp, Qingdao, Shandong, Peoples R China.
C3 Qingdao University
RP Sun, YW (通讯作者)，Zibo Cent Hosp, Dept Burns & Plast Surg, 54 Gong Qing Tuan Xi Rd, Zibo 255036, Shandong, Peoples R China.
EM syanwei005@163.com
RI sun, yanwei/LFS-0201-2024
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NR 28
TC 13
Z9 17
U1 0
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD 2022 JUN 15
PY 2022
AR 15347346221109045
DI 10.1177/15347346221109045
EA JUN 2022
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 2F7VM
UT WOS:000813113700001
PM 35706401
DA 2026-07-24
ER
PT J
AU Matsuzaki, K
   Miyamoto, A
AF Matsuzaki, Kyoichi
   Miyamoto, Akira
TI Limb Salvage with Multiple Modalities: A Case Report of a Diabetic Heel
   Ulcer Associated with Peripheral Arterial Disease
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE diabetic heel ulcer; endovascular therapy; maggot therapy;
   negative-pressure wound therapy; partial calcanectomy; peripheral
   arterial disease
ID LUCILIA-SERICATA-LARVAE; PRESSURE WOUND THERAPY
AB A large diabetic heel ulcer with peripheral arterial disease is an independent predictor of limb loss; below-knee amputation is not uncommon in such cases. One treatment is multimodal therapy, which includes partial calcanectomy. Because there is a limit to the ulcer surface area that can be sutured after partial calcanectomy, the remaining raw surface is treated with another method. In this case report, the authors describe a patient with peripheral arterial disease who had a 7 x 9-cm diabetic heel ulcer. The patient was treated with partial calcanectomy after catheter-based endovascular therapy revascularization and then maggot therapy after residual-wound dimensions were reduced by negative-pressure wound therapy.
C1 [Matsuzaki, Kyoichi] Int Univ Hlth & Welf, Sch Med, Dept Plast & Reconstruct Surg, Chiba, Japan.
   [Miyamoto, Akira] Takatsu Gen Hosp, Cardiovasc Ctr, Kawasaki, Kanagawa, Japan.
C3 International University of Health & Welfare
RP Matsuzaki, K (通讯作者)，Int Univ Hlth & Welf, Sch Med, Dept Plast & Reconstruct Surg, Chiba, Japan.
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NR 11
TC 2
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUL
PY 2022
VL 35
IS 7
DI 10.1097/01.ASW.0000831072.30829.15
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 2F9XR
UT WOS:000813255900004
PM 35723963
DA 2026-07-24
ER
PT J
AU Janssen, AHJ
   Lugt, AWVVD
   Wegdam, JA
   Reilingh, TSD
   van Dieren, S
   Vermeulen, H
   Eskes, AM
AF Janssen, Alexandra H. J.
   der Lugt, Andrea W. van Bruggen-van
   Wegdam, Johannes A.
   Reilingh, Tammo S. de Vries
   van Dieren, Susan
   Vermeulen, Hester
   Eskes, Anne M.
TI The association of potential prognostic determinants to nonadherence to
   negative pressure wound therapy: An exploratory prospective prognostic
   study
SO SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SHARED DECISION-MAKING; CARE; EXPERIENCE;
   SIMULATION; ADHERENCE; SELECTION; EVENTS; LIFE
AB Background: Up to now it is unclear which determinants influence nonadherence to negative pressure wound therapy. This study aimed to assess the predictive value of prognostic determinants to nonadherence to negative pressure wound therapy.Methods: A multicenter prospective cohort study on patients with wounds treated with negative pressure wound therapy. Data of 25 potential prognostic determinants of nonadherence were collected using a web-based case record form. Primary outcome was nonadherence to negative pressure wound therapy, defined as premature termination on request of the patient. Logistic regression analyses were used to explore the association between the potential determinants and nonadherence.Results: Nonadherence to negative pressure wound therapy was found in 32 out of 264 patients (12.1%). Univariable analyses identified 6 candidate prognostic determinants: having sensitive skin (odds ratio 2.32, 95% confidence interval 1.10-5.10, P = .03), decision for negative pressure wound therapy made as a shared decision (odds ratio 2.43, 95% confidence interval 1.06-6.30, P = .05), handiness technique (odds ratio 1.80, 95% confidence interval 0.86-3.89, P = .13), alternatives discussed (odds ratio 1.78, 95% confidence interval 0.83-3.75, P = .13), knowledge and understanding negative pressure wound therapy (odds ratio 0.50, 95% confidence interval 0.18-1.20, P = .15), and previous experience with negative pressure wound therapy (odds ratio 0.42, 95% confidence interval 0.10-1.24, P = .17). In the multivariable analysis, only having sensitive skin appeared to be significant (odds ratio 2.20, 95% confidence interval 1.02-4.85, P = .05).Conclusion: Patients who have sensitive skin may have an increased risk of premature termination of negative pressure wound therapy. Further research is warranted to determine which strategies are successful to overcome skin irritation problems to avoid nonadherence to negative pressure wound therapy.(c) 2022 Elsevier Inc. All rights reserved.
C1 [Janssen, Alexandra H. J.; Wegdam, Johannes A.; Reilingh, Tammo S. de Vries] Elkerliek Hosp, Dept Surg, Helmond, Netherlands.
   [der Lugt, Andrea W. van Bruggen-van] Univ Amsterdam, Master Evidence Based Practice Healthcare, Amsterdam, Netherlands.
   [van Dieren, Susan; Eskes, Anne M.] Univ Amsterdam, Dept Surg, Amsterdam UMC, Amsterdam, Netherlands.
   [Vermeulen, Hester] Radboud Univ Nijmegen, Sci Inst Qual Healthcare, Nijmegen, Netherlands.
   [Vermeulen, Hester] HAN Univ Appl Sci, Inst Nursing, Fac Hlth & Social Studies, Nijmegen, Netherlands.
   [Eskes, Anne M.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia.
   [Janssen, Alexandra H. J.] Elkerliek Hosp, Dept Surg, Wesselmanlaan 25, NL-5707 HA Helmond, Netherlands.
   [Eskes, Anne M.] Griffith Univ, Sch Nursing & Midwifery, Gold Coast, Australia.
C3 University of Amsterdam; University of Amsterdam; Radboud University
   Nijmegen; Menzies Health Institute Queensland; Griffith University;
   Griffith University
RP Janssen, AHJ (通讯作者)，Elkerliek Hosp, Dept Surg, Wesselmanlaan 25, NL-5707 HA Helmond, Netherlands.
EM sjanssen@elkerliek.nl
RI ; Eskes, Anne/HKV-3276-2023; Vermeulen, Hester/P-5739-2016
OI wegdam, johannes/0000-0002-3287-0233; Eskes, Anne
   Maria/0000-0003-1605-0195; Janssen, Alexana/0000-0003-1816-0814
CR Abbotts Joanne, 2010, Br J Nurs, V19, pS37
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NR 46
TC 3
Z9 3
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
EI 1532-7361
J9 SURGERY
JI Surgery
PD JUL
PY 2022
VL 172
IS 1
BP 349
EP 357
DI 10.1016/j.surg.2022.01.037
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2L3KA
UT WOS:000816916100048
PM 35248365
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Senne, M
   Werner, CR
   Schempf, U
   Thiel, K
   Königsrainer, A
   Wichmann, D
AF Senne, Moritz
   Werner, Christoph R.
   Schempf, Ulrike
   Thiel, Karolin
   Koenigsrainer, Alfred
   Wichmann, Doerte
TI Comparison of Two Endoscopic Therapeutic Interventions as Primary
   Treatment for Anastomotic Leakages after Total Gastrectomy
SO CANCERS
LA English
DT Article
DE esophagojejunal anastomotic leak; oncological gastrectomy; complication
   management; endoscopy
ID VACUUM-ASSISTED CLOSURE; INSUFFICIENCY; PERFORATIONS; MANAGEMENT;
   DEFECTS; LEAKS
AB Simple Summary An esophagojejunal anastomotic leak after oncological gastrectomy is a life-threatening complication. Endoscopic treatment offers the possibility of minimally invasive diagnosis and immediate effective therapy in one session. A retrospective, single-center analysis of two different endoscopic strategies as first-line treatment options was performed. Introduction: An esophagojejunal anastomotic leak following an oncological gastrectomy is a life-threatening complication, and its management is challenging. A stent application and endoscopic negative pressure therapy are possible therapeutic options. A clinical comparison of these strategies has been missing until now. Methods: A retrospective analysis of 14 consecutive patients endoscopically treated for an anastomotic leak after a gastrectomy between June 2014 and December 2019 was performed. Results: The mean time of the diagnosis of the leakage was 7.14 days after surgery. Five patients were selected for a covered stent, and nine patients received endoscopic negative pressure therapy. In the stent group, the mean number of endoscopies was 2.4, the mean duration of therapy was 26 days, and the mean time of hospitalization was 30 days. In patients treated with endoscopic negative pressure therapy, the mean number of endoscopies was 6.0, the mean days of therapy duration was 14.78, and the mean days of hospitalization was 38.11. Treatment was successful in all patients in the stent-based therapy group and in eight of nine patients in the negative pressure therapy group. Discussion: Good clinical results in preserving the anastomosis and providing sepsis control was achieved in all patients. Stent therapy resulted in anastomosis healing with a lower number of endoscopies, a shorter time of hospitalization, and rapid oral nutrition.
C1 [Senne, Moritz; Thiel, Karolin; Koenigsrainer, Alfred; Wichmann, Doerte] Univ Hosp Tubingen, Dept Gen Visceral & Transplantat Surg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
   [Werner, Christoph R.; Schempf, Ulrike] Univ Hosp Tubingen, Dept Gastroenterol Gastrointestinal Oncol Hepatol, Otfried Muller Str 10, D-72076 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital
RP Werner, CR (通讯作者)，Univ Hosp Tubingen, Dept Gastroenterol Gastrointestinal Oncol Hepatol, Otfried Muller Str 10, D-72076 Tubingen, Germany.
EM moritz.senne@med.uni-tuebingen.de;
   christoph.werner@med.uni-tuebingen.de;
   ulrike.schempf@med.uni-tuebingen.de; karolin.thiel@med.uni-tuebingen.de;
   alfred.koenigsrainer@med.uni-tuebingen.de;
   doerte.wichmann@med.uni-tuebingen.de
OI , Doerte/0000-0002-8832-5031
FU Open Access Publishing Fund of the University of Tubingen
FX This publication of the research was funded by the Open Access
   Publishing Fund of the University of Tubingen.
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NR 33
TC 9
Z9 10
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JUN
PY 2022
VL 14
IS 12
AR 2982
DI 10.3390/cancers14122982
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 2M1EV
UT WOS:000817452800001
PM 35740645
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sapino, G
   Lanz, L
   Roesti, A
   Guillier, D
   Deglise, S
   De Santis, G
   Raffoul, W
   di Summa, P
AF Sapino, Gianluca
   Lanz, Loise
   Roesti, Aurore
   Guillier, David
   Deglise, Sebastien
   De Santis, Giorgio
   Raffoul, Wassim
   di Summa, Pietro
TI One-Stage Coverage of Leg Region Defects with STSG Combined with VAC
   Dressing Improves Early Patient Mobilisation and Graft Take: A
   Comparative Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE wound healing; leg ulcer; skin graft; vac therapy
ID THICKNESS SKIN-GRAFT; ASSISTED CLOSURE DEVICE; PRESSURE WOUND THERAPY;
   MANAGEMENT; FOOT
AB Lower limb skin defects are very common and can result from a wide range of aetiologies. Split thickness skin graft (STSG) is a widely used method to address these problems. The role of postoperative dressing is primary as it permits one to apply a uniform pressure over the grafted area and promote adherence. Focusing on lower limb reconstruction, our clinical study compares the application of V.A.C. (Vacuum Assisted Closure) Therapy vs. conventional dressing in the immediate postoperative period following skin grafting. We included in the study all patients who received skin grafts on the leg region between January 2015 and December 2018, despite the aetiology of the defect. Only reconstructions with complete preoperative and postoperative follow-up data were included in the study. Patients were divided into two groups depending on if they received a traditional compressive dressing or a VAC dressing in the immediate postoperative period. We could retain 92 patients, 23 in the No VAC group and 69 in the VAC group. The patients included in the VAC group showed a statistically significant higher rate of graft take together with a lower immobilisation time (p < 0.05). Moreover, a lower rate of postoperative infection was recorded in the VAC group. This study represents the largest in the literature to report in detail surgical outcomes comparing the use of VAC therapy vs. conventional dressing after STSG in the postoperative management of lower limb reconstruction using skin grafts. VAC therapy was used to secure the grafts in the leg region, increasing the early graft take rate while at the same time improving patient mobilisation.
C1 [Sapino, Gianluca; Lanz, Loise; Raffoul, Wassim; di Summa, Pietro] Ctr Hosp Univ Vaudois CHUV, Dept Plast & Hand Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
   [Roesti, Aurore; Deglise, Sebastien] Ctr Hosp Univ Vaudois CHUV, Dept Vasc Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
   [Guillier, David] Univ Hosp, Dept Plast Reconstruct & Hand Surg, Dept Oral & Maxillofacial Surg, Blvd Lattre de Tassigny, F-21000 Dijon, France.
   [De Santis, Giorgio] Univ Hosp Modena, Dept Plast & Reconstruct Surg, Largo Pozzo 71, I-41100 Modena, Italy.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Universite Bourgogne Europe; CHU Dijon Bourgogne; Universita di Modena e
   Reggio Emilia; Universita di Modena e Reggio Emilia Hospital
RP di Summa, P (通讯作者)，Ctr Hosp Univ Vaudois CHUV, Dept Plast & Hand Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM gianluca.sapino@chuv.ch; loiselanz@unil.ch; aurore.roesti@chuv.ch;
   docteurguillierdavid@gmail.com; sebastien.deglise@chuv.ch;
   desantis.giorgio@unimore.it; wassim.raffoul@chuv.ch;
   pietro.disumma@gmail.com
RI ; De Santis, Giorgio/P-9027-2016
OI Deglise, Sebastien/0000-0001-8244-952X; raffoul,
   wassim/0000-0002-3524-0077
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
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NR 24
TC 13
Z9 15
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN
PY 2022
VL 11
IS 12
AR 3305
DI 10.3390/jcm11123305
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2M1SR
UT WOS:000817488800001
PM 35743375
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Timmer, AS
   Zwanenburg, PR
   Eskes, AM
   Hompes, R
   Boermeester, MA
AF Timmer, Allard S.
   Zwanenburg, Pieter R.
   Eskes, Anne M.
   Hompes, Roel
   Boermeester, Marja A.
TI The Effect of Negative-Pressure Wound Therapy with Instillation Compared
   to Current Standard Care on Wound Closure Time of Infected Wounds: A
   Systematic Review and Meta-Analysis
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Review
ID ANTISEPTIC SOLUTION; NORMAL SALINE; IRRIGATION; OUTCOMES; QUALITY
AB Background: Infected wounds extend healing time and are associated with higher treatment costs than noninfected wounds. Several observational studies indicate that negative-pressure wound therapy with instillation can effectively reduce bacterial bioburden and improve wound healing. Only a few randomized trials with small sample sizes have been published, and a meta-analysis directly comparing negative-pressure wound therapy with instillation to current standard care is lacking. It is therefore uncertain whether negative-pressure wound therapy with instillation actually improves wound healing. The authors performed a systematic review and hypothesized that negative-pressure wound therapy with instillation reduces wound closure time.
   Methods: The PubMed, Embase, and CENTRAL databases were searched up to December of 2020 for English studies that compare negative-pressure wound therapy with instillation-to either negative-pressure wound therapy without instillation or to other types of wound care-for the treatment of acute or chronically infected wounds. Time to wound closure was analyzed using a random effects meta-analysis in predefined subgroups according to study design and comparative wound care.
   Results: The authors identified 14 studies describing 1053 patients. Meta-analysis of three randomized trials shows no significant difference in time to wound closure between negative-pressure wound therapy with instillation and that without (mean difference, 0.48 day; 95 percent CI, -0.70 to 1.65; I-2 = 0 percent). Data from eleven observational studies indicate that negative-pressure wound therapy with instillation reduces wound closure time (from 1.6 to 16.8 days; no pooled data). Because of imprecision and risk of bias, the available evidence provides only low-level certainty.
   Conclusions: There is currently insufficient evidence to support or discard the use of negative-pressure wound therapy with instillation for infected wounds. More randomized trials are needed to determine whether a beneficial effect can be substantiated.
C1 [Timmer, Allard S.; Zwanenburg, Pieter R.; Eskes, Anne M.; Hompes, Roel; Boermeester, Marja A.] Univ Amsterdam, Amsterdam UMC locat AMC, Dept Surg, Amsterdam Gastroenterol & Metab, Amsterdam, Netherlands.
   [Timmer, Allard S.; Zwanenburg, Pieter R.; Eskes, Anne M.; Hompes, Roel; Boermeester, Marja A.] Griffith Univ, Menzies Hlth Inst Queensland, Griffith, NSW, Australia.
   [Timmer, Allard S.; Zwanenburg, Pieter R.; Eskes, Anne M.; Hompes, Roel; Boermeester, Marja A.] Griffith Univ, Sch Nursing & Midwifery, Griffith, NSW, Australia.
C3 University of Amsterdam; Griffith University; Griffith University
RP Boermeester, MA (通讯作者)，Amsterdam UMC, Locat AMC, Amsterdam Gastroenterol & Metab Amsterdam Infect, Dept Surg, Meibergdreef 9 Suite J1A 228, NL-1100 DD Amsterdam, Netherlands.
EM m.a.boermeester@amsterdamumc.nl
RI Eskes, Anne/HKV-3276-2023; Hompes, Roel/AAN-6249-2020
OI Eskes, Anne Maria/0000-0003-1605-0195
CR Chowdhry SA, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002087
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   Gabriel Allen, 2014, Eplasty, V14, pe41
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NR 36
TC 3
Z9 3
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUL
PY 2022
VL 150
IS 1
BP 176E
EP 188E
DI 10.1097/PRS.0000000000009232
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2N2DN
UT WOS:000818196600038
PM 35583955
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Vinnicombe, Z
   Singh, G
   Spiers, J
   Pouncey, AL
   McEvoy, H
   Lancaster, K
AF Vinnicombe, Z.
   Singh, G., V
   Spiers, J.
   Pouncey, A. L.
   McEvoy, H.
   Lancaster, K.
TI Comparison of Negative Pressure Wound Therapy with or without a
   Split-Thickness Skin Graft in the Surgical Management of Axillary
   Hidradenitis Suppurativa: A Retrospective Cohort Study
SO PLASTIC SURGERY
LA English
DT Article
DE dermatology; hidradenitis suppurativa; patient-reported outcome
   measures; plastic surgery; reconstruction; skin
ID EXCISION; SURGERY; RECURRENCE; GUIDELINES; EXPERIENCE; CLOSURE; FLAP
AB Introduction: Negative pressure wound therapy (NPWT) alone or with the addition of a split-thickness skin graft (STSG) are 2 reconstructive options available after surgical excision of axillary hidradenitis suppurativa (HS). The aim of this study was to retrospectively examine patients undergoing these treatments and to assess clinical and patient-related outcome measures. Methods: A single-centre, retrospective analysis was conducted, evaluating surgical excision of axillary HS, with STSG and NPWT, or NPWT alone. Data collected included No. of post-operative clinic visits, time to heal, size of wound, disease recurrence, follow-up time, Dermatology Life Quality Index (DLQI), the Generalised Anxiety Disorder Assessment (GAD-7), the Patient Health Questionnaire Depression Scale (PHQ-9), Pain Visual Analogue Scale (PAINVAS2), the Brief Illness Perception Questionnaire (BIPQ), and Dermatology Visual Analogue Scale (DERMVAS). Two-tailed t-test and Mann-Whitney Wilcoxon U-tests were used to assess for significant relationships. Results: One hundred five patients were included in the study, 44 who received NPWT alone, and 61 who received NPWT + STSG. There was no significant difference in follow-up time (P = .934) or No. of follow-up appointments between groups (P = .287). There was a significant difference in time to heal between groups, with STSG + NPWT observing a mean time of 2.77 months and NPWT alone observing a mean time of 4.40 months (P = .0006). There was no difference in patient-reported outcomes between the 2 groups. Conclusion: There is no difference in patient-reported outcomes with the addition of an STSG to NPWT after surgical excision of HS. Wide excision and use of NPWT alone is an effective procedure for the treatment of axillary HS.
C1 [Vinnicombe, Z.; Pouncey, A. L.; McEvoy, H.; Lancaster, K.] St Thomas Hosp, Dept Plast & Reconstruct Surg, London SE1 7EH, England.
   [Singh, G., V; Spiers, J.] Kings Coll London, GKT Sch Med Educ, London, England.
C3 Guy's & St Thomas' NHS Foundation Trust; University of London; King's
   College London
RP Vinnicombe, Z (通讯作者)，St Thomas Hosp, Dept Plast & Reconstruct Surg, London SE1 7EH, England.
EM zvinnicombe@gmail.com
RI ; Pouncey, Anna Louise/HJB-2757-2022
OI Spiers, Jessica/0000-0002-3207-8588; Vinnicombe,
   Zak/0000-0003-0493-5682; Singh, Gurdas/0000-0003-1604-5353; Pouncey,
   Anna Louise/0000-0003-2329-6193
CR Alharbi Z, 2012, BMC DERMATOL, V12, DOI 10.1186/1471-5945-12-9
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NR 40
TC 2
Z9 2
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2292-5503
EI 2292-5511
J9 PLAST SURG-CHIR PLAS
JI Plast. Surg.
PD MAY
PY 2024
VL 32
IS 2
BP 314
EP 320
AR 22925503221109006
DI 10.1177/22925503221109006
EA JUN 2022
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OI0L4
UT WOS:000818556700001
PM 38681254
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Vidalis, BM
   Ngwudike, S
   McCandless, MG
   Chohan, MO
AF Vidalis, Benjamin M.
   Ngwudike, Somtochukwu, I
   McCandless, Martin G.
   Chohan, Muhammad O.
TI Negative Pressure Wound Therapy in Facilitating Wound Healing After
   Surgical Decompression for Metastatic Spine Disease
SO WORLD NEUROSURGERY
LA English
DT Article
DE Metastatic spine disease; Negative pressure wound therapy; Surgical site
   infection
ID VACUUM-ASSISTED CLOSURE; SITE INFECTION; RISK-FACTORS; SURGERY;
   COMPLICATIONS; MANAGEMENT
AB BACKGROUND: The risk of wound-related complications, including surgical site infections (SSIs), in patients undergoing surgery for metastatic spine disease (MSD) is high. Consequently, patients requiring wound revision surgery face delay in resuming oncological care and incur additional hospitalization. Recent reports suggest that negative pressure wound therapy (NPWT) applied on a closed wound at the time of surgery significantly reduces postoperative wound complications in degenerative spine disease and trauma setting. Here, we report a single institution experience with incisional NPWT in patients undergoing surgery for MSD.
   METHODS: We compared rates of wound complications requiring surgical revision in a surgical cohort of patients with or without NPWT from 2015 to 2020. Adult patients with radiographic evidence of MSD with mechanical instability and/or accelerated neurological decline were included in the study. NPWT was applied on a closed wound in the operating room and continued for 5 days or until discharge, whichever occurred first.
   RESULTS: A total of 42 patients were included: 28 with NPWT and 14 without. Patient demographics including underlying comorbidities were largely similar. NPWT patients had higher rates of prior radiation to the surgical site (36% vs. 0%, P = 0.017) and longer fusion constructs (6.7 vs. 3.9 levels, P < 0.001). Three patients (21%) from the control group and none from the NPWT group contracted SSI requiring wound washout (P = 0.032).
   CONCLUSIONS: Our data suggest that SSI and wound dehiscence are significantly reduced with the addition of incisional NPWT in this vulnerable population.
C1 [Vidalis, Benjamin M.; Chohan, Muhammad O.] Univ New Mexico, Dept Neurosurg, Albuquerque, NM 87131 USA.
   [Ngwudike, Somtochukwu, I; McCandless, Martin G.; Chohan, Muhammad O.] Univ Mississippi, Med Ctr, Dept Neurosurg, Jackson, MS 39216 USA.
C3 University of New Mexico; University of Mississippi Medical Center;
   University of Mississippi
RP Chohan, MO (通讯作者)，Univ New Mexico, Dept Neurosurg, Albuquerque, NM 87131 USA.; Chohan, MO (通讯作者)，Univ Mississippi, Med Ctr, Dept Neurosurg, Jackson, MS 39216 USA.
EM mchohan@umc.edu
RI ; Chohan, Muhammad/ABG-1163-2021
OI McCandless, Martin/0000-0002-9068-8683; 
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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   Wang Junru, 2006, Hernia, V10, P502, DOI 10.1007/s10029-006-0150-y
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NR 37
TC 11
Z9 11
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD MAR
PY 2022
VL 159
BP E407
EP E415
DI 10.1016/j.wneu.2021.12.063
EA MAR 2022
PG 9
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 2P6JU
UT WOS:000819845600023
PM 34954060
DA 2026-07-24
ER
PT J
AU Lygrisse, KA
   Teo, G
   Singh, V
   Muthusamy, N
   Schwarzkopf, R
   William, L
AF Lygrisse, Katherine A.
   Teo, Greg
   Singh, Vivek
   Muthusamy, Nishanth
   Schwarzkopf, Ran
   William, Long
TI Comparison of silver-embedded occlusive dressings and negative pressure
   wound therapy following total joint arthroplasty in high BMI patients: a
   randomized controlled trial
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE Obesity; Wound dressing; Total joint arthroplasty; Negative pressure
   wound therapy; Wound complications; Prosthetic joint infection
ID SURGICAL SITE COMPLICATIONS; TOTAL KNEE ARTHROPLASTY; HIP;
   OSTEOARTHRITIS; INFECTION; RISK; SURGERY; AQUACEL; COST
AB Introduction High body mass index (BMI) and wound drainage following total joint arthroplasty (TJA) can lead to wound healing complications and periprosthetic joint infection. Silver-embedded occlusive dressings and negative pressure wound therapy (NPWT) have been shown to reduce these complications. The purpose of this prospective trial was to compare the effect of silver-embedded dressings and NPWT on wound complications in patients with BMI >= 35 m/kg2 undergoing TJA. Methods We conducted a randomized control trial of patients who had a BMI > 35 m/kg(2) and were undergoing primary TJA between October 2017 and February 2020. Patients who underwent revision surgery, or those with an active infection, previous scar, history of wound healing complications, post-traumatic degenerative joint disease with hardware, or inflammatory arthritis were excluded. Patients were randomized to receive either a silver-embedded occlusive dressing (control) or NPWT. Frequency distributions, means, and standard deviations were used to describe patient demographics, postoperative complications, 90-day readmissions, and reoperations. T-test and chi-squared tests were used to test for significant differences between continuous and categorical variables, respectively. Results Two hundred-thirty patients with 3-month follow-up were included. One-hundred-fifteen patients received the control and 115 patients received NPWT. There were six patients (5.2%) in the control group with wound complications (drainage: n = 5, non-healing wound: n = 1) and two patients (1.7%) in the NPWT with complications (drainage: n = 2). There were no 90-day readmissions in the control group versus two (1.8%) 90-day readmissions in the NPWT group. Finally, three patients (2.6%) in the control group underwent reoperations (irrigation and debridement [I&D], I&D with modular implant exchange, and implant revision), while none in the NPWT group had undergone reoperation. The two groups showed insignificant differences in wound complications (p = 0.28), 90-day readmissions (p = 0.50), and reoperations (p = 0.25). Conclusion Patients with BMI >= 35 m/kg2 undergoing TJA have no statistical difference in early wound complications, readmissions, or reoperations when treated with either silver-embedded dressings or NPWT.
C1 [Lygrisse, Katherine A.] Zucker Sch Med Hofstra Northwell, Huntington Hosp, Dept Orthoped Surg, 270 Pk Ave, Huntington, NY 11743 USA.
   [Teo, Greg; William, Long] Hosp Special Surg, Dept Orthoped Surg, 541 East 71st St,7th Fl, New York, NY 10021 USA.
   [Singh, Vivek; Muthusamy, Nishanth; Schwarzkopf, Ran] NYU Langone Hlth, Dept Orthoped Surg, 301 East 17th St,15th Fl Suite 1518, New York, NY 10003 USA.
   [Muthusamy, Nishanth] NYU Langone Hlth, Dept Orthoped Surg, Div Adult Reconstruct Surg, 301 East 17th St, New York, NY 10003 USA.
C3 Northwell Health; NYU Langone Medical Center; NYU Langone Medical Center
RP Muthusamy, N (通讯作者)，NYU Langone Hlth, Dept Orthoped Surg, 301 East 17th St,15th Fl Suite 1518, New York, NY 10003 USA.; Muthusamy, N (通讯作者)，NYU Langone Hlth, Dept Orthoped Surg, Div Adult Reconstruct Surg, 301 East 17th St, New York, NY 10003 USA.
EM nmuthusamy13@gmail.com
OI Muthusamy, Nishanth/0000-0003-1227-7093
CR ANDERSON JJ, 1988, AM J EPIDEMIOL, V128, P179, DOI 10.1093/oxfordjournals.aje.a114939
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NR 29
TC 7
Z9 7
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD JUN
PY 2023
VL 143
IS 6
BP 2989
EP 2995
DI 10.1007/s00402-022-04530-1
EA JUL 2022
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA G9CW0
UT WOS:000819896800002
PM 35779102
DA 2026-07-24
ER
PT J
AU Zhang, MY
   Zhang, HL
   Tang, B
   Fu, J
   Yan, HY
   Luo, HL
AF Zhang, Mingyi
   Zhang, Haolong
   Tang, Bo
   Fu, Jian
   Yan, Haiyan
   Luo, Hailong
TI Outcomes of Covered Stents With Vacuum Sealing Drainage For Treatment of
   Infected Femoral Pseudoaneurysms in Intravenous Drug Addicts
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID ARTERY PSEUDOANEURYSM; MYCOTIC PSEUDOANEURYSMS; MANAGEMENT; ANEURYSMS;
   LIGATION
AB Objective: For treatment of infected femoral artery pseudoaneurysms (IFAPs) with the covered stent, debridement technique is important but frequently ignored. Our study aims to review our experience and outcomes of patients undergoing covered stents placement and debridement with vacuum sealing drainage (VSD).
   Methods: This study retrospectively analyzed 41 intravenous drug addicts with IFAP who received covered stent implantation and debridement with VSD from January 2015 to December 2020. The diagnosis was based on the previous history of local injection and the presence of pulsatile mass at the injection site. All cases were confirmed by CT angiography (CTA), ultrasound, or digital subtraction angiography (DSA). Technical success, time of wound care, and clinical outcomes were evaluated.
   Results: Technical success was achieved in all patients. The interval from diagnosis to treatment was 26 +/- 11 hours. The time of continuous drainage with VSD was 18.79 +/- 6.56 days. 38 patients (92.68%) with fresh granulation tissue were sutured and discharged from the hospital. Stents in 31(91.18%) of 34 cases were patent during follow-ups. Three patients had stent occlusion caused by thrombosis, and two of them were complicated with stent infection. The two infectious stents were removed and the femoral arteries were ligated. One of them received open-surgical reconstruction with the great saphenous because of claudication. Two patients were admitted to the hospital for rebleeding caused by drug abuse relapse.
   Conclusions: Covered stents placement is convenient and rapid to control massive hemorrhage in IFAPs of intravenous drug abuse. Early debridement of infected tissue with continued VSD may shorten the time of wound care and make the incidence of stent infection relatively low. Meanwhile, the patency in a short time follow-up is acceptable. These results indicate that covered stents implantation with VSD may be a safe, effective, and feasible measure for the treatment of IFAPs.
C1 [Zhang, Mingyi; Zhang, Haolong; Tang, Bo; Fu, Jian; Yan, Haiyan; Luo, Hailong] Chongqing Med Univ, Affiliated Hosp 2, Dept Vasc Surg, 76 Linjiang Rd, Chongqing 400010, Peoples R China.
C3 Chongqing Medical University
RP Luo, HL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Vasc Surg, 76 Linjiang Rd, Chongqing 400010, Peoples R China.
EM surgeonhailong@qq.com
RI Luo, Hailong/OYD-5075-2025
CR D'Oria M, 2017, CARDIOVASC INTER RAD, V40, P616, DOI 10.1007/s00270-016-1527-7
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NR 20
TC 3
Z9 4
U1 1
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD APR
PY 2022
VL 81
BP 300
EP 307
DI 10.1016/j.avsg.2021.09.029
EA APR 2022
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 2Q9DG
UT WOS:000820716300037
PM 34780965
DA 2026-07-24
ER
PT J
AU Barry, IP
   Turley, LP
   Gwilym, BL
   Bosanquet, DC
   Richards, T
AF Barry, Ian Patrick
   Turley, Luke P.
   Gwilym, Brenig L.
   Bosanquet, David C.
   Richards, Toby
TI Impact of closed-incision negative pressure wound dressings on surgical
   site infection following groin incisions in vascular surgery; a
   single-centre experience
SO VASCULAR
LA English
DT Article
DE Closed-incisions negative; pressure wound therapy; closed-incision
   negative pressure wound therapy; vascular; vascular surgery; surgical
   site infection; groin incision
ID LOWER-EXTREMITY BYPASS; RISK-FACTORS; THERAPY; READMISSION; PREVENTION;
   TRENDS
AB Objectives: Surgical site infection (SSI) is a common complication in vascular surgery, and is associated with increased patient morbidity, readmission and reintervention. The aim of this study was to assess the impact of closed-incision negative pressure wound therapy (CiNPWT) upon rate of SSI and length of hospital stay.
   Methods: This study was reported in line with the STROBE guidelines. We assessed the baseline incidence of SSI from a 12-month retrospective cohort and, following a change in practice intervention with CiNPWT, compared to a 6-month prospective cohort. The primary endpoint was incidence of SSI (according to CDC-NHSN guidelines) while secondary endpoints included length of hospital stay, readmission, reintervention and Days Alive and Out of Hospital (DAOH) to 90-days.
   Results: A total of 127 groin incisions were performed: 76 (65 patients) within the retrospective analysis and 51 (42 patients) within the prospective analysis (of whom 69% received CiNPWT). The primary endpoint of SSI was seen in 21.1% of the retrospective cohort and 9.8% of the prospective cohort (p =.099). Readmission was found to be significantly associated with the retrospective cohort (p =.016) while total admission (inclusive of re-admission) was significantly longer in those in the retrospective cohort (p =.013). DAOH-90 was 83 days (77-85) following introduction of the CiNPWT protocol as compared to the retrospective cohort (77 days (64-83), p =.04).
   Conclusion: Introduction of CiNPWT was associated with a reduced length of hospital stay and improved DAOH-90. Further trials on CINPWT should include patient-centred outcomes and healthcare cost analysis.
C1 [Barry, Ian Patrick; Richards, Toby] Fiona Stanley Hosp, Dept Vasc Surg, Perth, WA, Australia.
   [Turley, Luke P.] Sir Charles Gairdner Hosp, Dept Gen Surg, Nedlands, WA, Australia.
   [Gwilym, Brenig L.; Bosanquet, David C.] Aneurin Bevan Univ Hlth Board, Dept Vasc Surg, Newport, Gwent, Wales.
   [Richards, Toby] Univ Western Australia, Perth, WA, Australia.
C3 South Metropolitan Health Service; Fiona Stanley Fremantle Hospitals
   Group; Fiona Stanley Hospital; Sir Charles Gairdner Hospital; University
   of Western Australia; University of Western Australia
RP Barry, IP (通讯作者)，Fiona Stanley Hosp, Dept Vasc Surg, 11 Robin Warren Dr, Murdoch, WA 6010, Australia.
EM Ian.Barry@health.wa.gov.au
RI Gwilym, Brenig/HJA-5869-2022; Richards, Toby/K-6547-2013; Bosanquet,
   David/AAB-1557-2022
OI Richards, Toby/0000-0001-9872-4653; Barry, Ian/0000-0002-2414-9315;
   Bosanquet, David/0000-0003-2304-0489
CR Bell M, 2019, ECLINICALMEDICINE, V11, P18, DOI 10.1016/j.eclinm.2019.04.011
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NR 27
TC 3
Z9 4
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD DEC
PY 2023
VL 31
IS 6
BP 1128
EP 1133
AR 17085381221111007
DI 10.1177/17085381221111007
EA JUN 2022
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Y8QU5
UT WOS:000821085500001
PM 35759405
DA 2026-07-24
ER
PT J
AU Song, QC
   Li, D
   Zhao, Y
   Zhang, GY
   Shang, DL
   Fan, LH
   Dang, XQ
AF Song, Qi-Chun
   Li, Dong
   Zhao, Yan
   Zhang, Guang-Yang
   Shang, Dong-Long
   Fan, Li-Hong
   Dang, Xiao-Qian
TI Negative pressure wound therapy reduces the incidence of postoperative
   wound dehiscence and surgical site infections after total knee
   arthroplasty in patients with obesity
SO MEDICINE
LA English
DT Article
DE negative pressure wound treatment; obesity; surgical site infection;
   total knee replacement; wound dehiscence
ID COMPLICATION; HIP
AB Obesity is a risk factor for total knee arthroplasty (TKA). Wound dehiscence and surgical site infections (SSIs) are the main complications of TKA in patients with obesity. They can profoundly affect patients because they often require readmission, additional surgical interventions, lengthy intravenous antibiotic administration, and delayed rehabilitation. Negative pressure wound therapy (NPWT) exposes the wound site to negative pressure, resulting in the improvement of blood supply, removal of excess fluid, and stimulation of cellular proliferation of granulation tissue. This study aims to assess the incidence of wound dehiscence and SSIs in patients with obesity undergoing TKA after the routine use of NPWT. This sduty enrolled adult patients with obesity who underwent TKA within 8 years. A total of 360 adult patients with obesity (NPWT: 150, non-NPWT: 210) underwent TKA, and the baseline characteristics were similar between the 2 groups. Compared with the non-NPWT group, the NPWT group had a 50% lower incidence of wound dehiscence (3.33% vs 9.52%; P < .05) and a significantly lower incidence of SSIs (11.33% vs 25.24%; P < .05), including prosthetic joint infection (4.0% vs 10.0%; P < .05) and superficial wound infection (7.33% vs 15.24%; P < .05). In addition, the NPWT group had a lower need to return to the operating room for new interventions for any reason (2.67% vs 9.05%; P = .0107) than the non-NPWT group. Conventional incision NPWT can significantly reduce the incidence of wound dehiscence and SSIs in patients with obesity after TKA.
C1 [Song, Qi-Chun; Li, Dong; Zhao, Yan; Zhang, Guang-Yang; Shang, Dong-Long; Fan, Li-Hong; Dang, Xiao-Qian] Xi An Jiao Tong Univ, Affiliated Hosp 2, Xian, Peoples R China.
C3 Xi'an Jiaotong University
RP Dang, XQ (通讯作者)，Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthopaed, 157 Xiwu Rd, Xian 710004, Shaanxi, Peoples R China.
EM 2000bjjy@163.com; z578409218@163.com; guangyangz97@163.com;
   413526720@qq.com; zhibin_shi@126.com; xqdang@126.com
FU National Natural Science Foundation of China [82002311]; China
   Postdoctoral Science Foundation [2021M692575]
FX The present study was funded by the National Natural Science Foundation
   of China (grant no. 82002311) and China Postdoctoral Science Foundation
   (grant no. 2021M692575).
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NR 27
TC 13
Z9 15
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL 8
PY 2022
VL 101
IS 27
AR e29641
DI 10.1097/MD.0000000000029641
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2S8MX
UT WOS:000822042900013
PM 35801735
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Orlov, A
   Gefen, A
AF Orlov, Aleksei
   Gefen, Amit
TI Effective negative pressure wound therapy for open wounds: The
   importance of consistent pressure delivery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE animal study; bioengineering laboratory research of chronic wounds;
   diabetic foot ulcer; finite element modelling; pressure ulcer; injury
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; SINGLE-USE; MIGRATION;
   COLLAGEN; BURDEN
AB Two distinct design concepts exist for single-use negative pressure wound therapy systems: Canister-based versus canisterless. The canister-based technology provides intrinsic stable delivery of the intended negative pressure, because exudate is constantly transferred from the wound into a canister, thereby preventing dressing saturation. In contrast, with a canisterless system, where delivery of the negative pressure depends on continuous evaporation of wound fluids from its dressing, loss of the intended wound-bed pressure may occur due to dressing saturation. To investigate whether these two designs differ in their mechanobiological effect with respect to magnitudes and distributions of tissue strain fields under the absorptive dressing, termed the influence zone, we integrated computational modelling with an animal study. This influence zone must be of biologically influential strain levels and extend sufficiently into the peri-wound for stimulating fibroblasts to migrate and progress the healing. We found that an effective influence zone requires continuous delivery of the intended pressure to the wound-bed. Loss of negative pressure at the wound-bed below 40 mmHg adversely lowered the peri-wound stimulation around a 120 x 70 mm sized wound to less than one-third of the baseline stimulation, and further pressure decreases to 20 mmHg or lower resulted in complete lack of peri-wound mechano-stimulation.
C1 [Orlov, Aleksei; Gefen, Amit] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, Tel Aviv, Israel.
C3 Tel Aviv University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Dept Biomed Engn, Herbert J Berman Chair Vasc Bioengn, IL-6997801 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
OI Gefen, Amit/0000-0002-0223-7218
FU Molnlycke Health Care; Israeli Ministry of Science Technology [3-17421];
   European Union [811965]
FX Molnlycke Health Care; Israeli Ministry of Science & Technology,
   Grant/Award Number: 3-17421; European Union's Horizon 2020 research and
   innovation programme, Grant/Award Number: 811965
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NR 57
TC 14
Z9 14
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2023
VL 20
IS 2
BP 328
EP 344
DI 10.1111/iwj.13879
EA JUL 2022
PG 17
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8K9TL
UT WOS:000822976900001
PM 35818745
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chicco, M
   Ahmadi, AR
   Lin, FY
   Cheng, HT
   Lee, MM
AF Chicco, Maria
   Ahmadi, Ali R.
   Lin, Fu-Yu
   Cheng, Hsu-Tang
   Lee, Min-Min
TI Combination of Autologous Fat Grafting and Negative-Pressure Wound
   Therapy for the Treatment of Scalp Linear Scleroderma
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Craniofacial reconstruction; fat grafting; negative-pressure wound
   therapy; scalp linear scleroderma
ID TERM
AB Scalp linear scleroderma (LSc) is a subtype of localized scleroderma which typically affects young patients and which can be severely disfiguring. Traditional treatment options include bone grafting or tissue expansion. in this report, we present the case of a patient with scalp LSc successfully treated with scar release, autologous fat grafting, and negative-pressure wound therapy (NPWT). A 55-year-old female, with a history of craniectomy for a benign sellar tumor 10 years previously, developed LSc over the frontal scalp with exposure of titanium plates and screws. She was treated with removal of metalwork, scar release, autologous fat grafting from the abdominal wall and immediate application of NPWT. At 3-month postoperative follow-up, the appearance of the depressed lesion and of its margins had significantly improved. Our experience suggests that the combination of autologous fat grafting and NPWT is an effective treatment modality for scalp LSc.
C1 [Chicco, Maria] Oxford Univ Hosp NHS Fdn Trust, Dept Surg, John Radcliffe Hosp, Oxford, England.
   [Ahmadi, Ali R.] Erasmus MC, Dept Plast & Reconstruct Surg, Rotterdam, Netherlands.
   [Lin, Fu-Yu] China Med Univ, Dept Neurol, China Med Univ Hosp, Sch Med, Taichung, Taiwan.
   [Cheng, Hsu-Tang] Asia Univ, Coll Med & Hlth Sci, Div Plast & Reconstruct Surg, Dept Surg,Asia Univ Hosp, 222 Fuxin Rd, Taichung 41354, Taiwan.
   [Cheng, Hsu-Tang] China Med Univ Hosp, Big Data Ctr, Taichung, Taiwan.
   [Cheng, Hsu-Tang; Lee, Min-Min] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan.
C3 University of Oxford; Oxford University Hospitals NHS Foundation Trust;
   Erasmus University Rotterdam; Erasmus MC; China Medical University
   Taiwan; China Medical University Hospital - Taiwan; Asia University
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; Asia University Taiwan
RP Cheng, HT (通讯作者)，Asia Univ, Coll Med & Hlth Sci, Div Plast & Reconstruct Surg, Dept Surg,Asia Univ Hosp, 222 Fuxin Rd, Taichung 41354, Taiwan.
EM hsutangcheng@gmail.com
FU Asia University Hospital Research Program [AUH-10951018]
FX This study is supported in part by Asia University Hospital Research
   Program (AUH-10951018).
CR Careta MF, 2015, AN BRAS DERMATOL, V90, P62, DOI 10.1590/abd1806-4841.20152890
   Hwang Dong Yeon, 2009, J Plast Reconstr Aesthet Surg, V62, pe25, DOI 10.1016/j.bjps.2007.12.019
   Kao HK, 2015, BRIT J SURG, V102, P998, DOI 10.1002/bjs.9826
   Kaufman MR, 2007, PLAST RECONSTR SURG, V119, P323, DOI 10.1097/01.prs.0000244903.51440.8c
   Lee SS, 2017, J CRANIOFAC SURG, V28, P629, DOI 10.1097/SCS.0000000000003410
   Thareja SK, 2015, INT J DERMATOL, V54, P823, DOI 10.1111/ijd.12108
   Zuk PA, 2002, MOL BIOL CELL, V13, P4279, DOI 10.1091/mbc.E02-02-0105
NR 7
TC 1
Z9 1
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD JUL-AUG
PY 2022
VL 33
IS 5
BP E459
EP E461
DI 10.1097/SCS.0000000000008355
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2U5AT
UT WOS:000823174200007
PM 34759251
DA 2026-07-24
ER
PT J
AU Brennfleck, FW
   Bongards, C
AF Brennfleck, Frank W.
   Bongards, Christine
TI Health economic assessment of negative pressure wound therapy use in the
   management of subcutaneous abdominal wound healing impairment (SAWHI) in
   the out-of-hospital setting
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE cost-benefit analysis; economic model; negative pressure wound therapy;
   wound healing
ID CARE
AB Development of subcutaneous abdominal wound healing impairment (SAWHI) can greatly affect patient care. Complications from SAWHI include delayed healing, increased risk of infection, and fascial dehiscence resulting in increased patient care and associated costs. Treatment options include conventional wound treatment or negative pressure wound therapy, both of which can be used in the out-of-hospital setting. However, limited published evidence on cost-effectiveness exists. A conservative health economic model was created to assess the cost-benefit of negative pressure wound therapy in the out-of-hospital setting for the management of SAWHI. Study data from a published multicentre randomised controlled trial was used and represented 221 patients that received care in the out-of-hospital setting. The mean per-patient total cost within 42 days was slightly higher in the negative pressure wound therapy group (2034.98 euro versus 1918.91 euro); however, when wound closure rates were considered, a cost savings of 4155.98 euro per closed wound was observed with the use of negative pressure wound therapy (4324.34 euro versus 8480.32 euro). A cost-effectiveness analysis was constructed, and negative pressure wound therapy was observed to have a lower cost of care and a higher incremental closure rate.
C1 [Brennfleck, Frank W.] Main Kinzig Kliniken, Dept Gen Visceral & Vasc Surg, Herzbachweg 14, D-63571 Gelnhausen, Germany.
   [Bongards, Christine] 3M Deutschland GmbH, 3M, Global Hlth Econ & Outomes Res, Neuss, Germany.
C3 3M
RP Brennfleck, FW (通讯作者)，Main Kinzig Kliniken, Dept Gen Visceral & Vasc Surg, Herzbachweg 14, D-63571 Gelnhausen, Germany.
EM frank.brennfleck@ukr.de
RI Brennfleck, Frank/GOV-6490-2022
OI Brennfleck, Frank/0000-0001-8055-9282
CR [Anonymous], 2022, LAUER-TAXE®- reliable pharmaceutical information for all drugs and contracts registered in Germany
   [Anonymous], 2022, FEE SCHEDULE DOCTORS
   [Anonymous], PERSONNEL COSTS
   [Anonymous], DOCTARI MAGAZIN
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   de Leon JM, 2009, ADV SKIN WOUND CARE, V22, P122, DOI 10.1097/01.ASW.0000305452.79434.d9
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   Seidel D, 2020, JAMA SURG, V155, P469, DOI 10.1001/jamasurg.2020.0414
   Sellmer, PRICE INFORM MODERN
   Wegener, NURSE SALARY WHAT NU
NR 12
TC 6
Z9 6
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2023
VL 20
IS 2
BP 458
EP 466
DI 10.1111/iwj.13894
EA JUL 2022
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8K9TL
UT WOS:000824399700001
PM 35833308
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Stumpfe, MC
   Horch, RE
   Arkudas, A
   Cai, A
   Müller-Seubert, W
   Hauck, T
   Ludolph, I
AF Stumpfe, M. C.
   Horch, R. E.
   Arkudas, A.
   Cai, A.
   Mueller-Seubert, W.
   Hauck, T.
   Ludolph, I.
TI The Value of Negative-Pressure Wound Therapy and Flap Surgery in
   Hidradenitis Suppurativa - A Single Center Analysis of Different
   Treatment Options
SO FRONTIERS IN SURGERY
LA English
DT Article
DE negative-pressure wound therapy; acne inversa; hidradenitis suppurativa;
   bacterial burden; flap surgery
ID VACUUM-ASSISTED CLOSURE; SURGICAL-MANAGEMENT; RECONSTRUCTION;
   RECURRENCE; EXCISION; DEFECTS
AB Background: Hidradenitis suppurativa is manifested by painful abscesses and scarring of sweat glands. Axillary, inguinal and genital regions are mostly affected. Multiple options exist in the treatment of hidradenitis suppurativa. The aim of this retrospective, mono-center cohort study was to analyze the outcome of different treatment methods after radical excision of hidradenitis suppurativa. Methods: We retrospectively evaluated the treatment strategy and recurrence rate of hidradenitis suppurativa. We included all eligible patients of legal age between February 2003 and October 2021, with the diagnosis of Hidradenitis suppurativa and the necessity for surgical treatment. All patients with surgical treatment and direct wound closure by suture were excluded. Bacterial load and flora were analyzed for primary and secondary reconstruction in combination with negative-pressure wound therapy. Patient data were analyzed for recurrence rate and remission time according to different reconstructive techniques. Results: In 44 affected anatomical sites (n = 23 patients) we treated 15 patients with negative-pressure wound therapy. Bacterial load and flora were lower in the last wound swab of patients with multi-surgical procedures (22 localizations) compared to the first wound swab independent of the use of negative-pressure wound therapy. Wound closure, independent of a direct and multi-stage procedure was achieved by local fasciocutaneous flaps (n = 12), secondary intention healing (n = 7), secondary intention healing with buried chip skin grafts (n = 10), or split-thickness skin grafts (n = 15). Radical excision combined with split-thickness skin grafts showed the lowest recurrence rate in the follow-up (16%; n = 4). Conclusion: Radical excision of hidradenitis suppurativa as gold standard for surgical treatment combined with negative-pressure wound therapy as multi-stage procedures ultimately reduced bacterial load and flora in our study. The use of split-thickness skin grafts showed the lowest recurrence rate.
C1 [Stumpfe, M. C.; Horch, R. E.; Arkudas, A.; Cai, A.; Mueller-Seubert, W.; Hauck, T.; Ludolph, I.] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Hosp Erlangen, Dept Plast & Hand Surg, Lab Tissue Engn & Regenerat Med, Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Stumpfe, MC (通讯作者)，Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Hosp Erlangen, Dept Plast & Hand Surg, Lab Tissue Engn & Regenerat Med, Erlangen, Germany.
EM maximilian.stumpfe@uk-erlangen.de
RI Horch, Raymund/H-8128-2019; Cai, Aijia/JXN-8479-2024; Stumpfe,
   Maximilian/LRS-7265-2024; Arkudas, Andreas/AAQ-6745-2021
OI Stumpfe, Maximilian/0000-0003-1338-1060; 
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   Chen YE, 2014, PLAST RECONSTR SURG, V133, p370E, DOI 10.1097/PRS.0000000000000080
   CHICARILLI ZN, 1987, ANN PLAS SURG, V18, P230, DOI 10.1097/00000637-198703000-00009
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   Mehdizadeh A, 2015, J AM ACAD DERMATOL, V73, pS70, DOI 10.1016/j.jaad.2015.07.044
   Muenchow S, 2019, CLIN HEMORHEOL MICRO, V72, P365, DOI 10.3233/CH-180536
   Müller-Seubert W, 2021, INT WOUND J, V18, P942, DOI 10.1111/iwj.13683
   Muller-Seubert W, 2021, INT WOUND J, V18, P932, DOI 10.1111/iwj.13639
   Ngaage LM, 2020, INT WOUND J, V17, P117, DOI 10.1111/iwj.13241
   Orenstein LAV, 2020, DERMATOLOGY, V236, P393, DOI 10.1159/000507323
   Ovadja ZN, 2021, DERMATOL SURG, V47, pE106, DOI 10.1097/DSS.0000000000002815
   Ovadja ZN, 2020, DERMATOL SURG, V46, pE1, DOI 10.1097/DSS.0000000000002403
   Parrado R, 2017, INT WOUND J, V14, P35, DOI 10.1111/iwj.12544
   Polykandriotis E, 2019, INT WOUND J, V16, P503, DOI 10.1111/iwj.13063
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   Steiner D, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.00177
   Stumpfe Maximilian C, 2020, Wounds, V32, pE101
   Tang JB, 2015, INT WOUND J, V12, P334, DOI 10.1111/iwj.12116
   Taylor EM, 2021, PLAST RECONSTR SURG, V147, p479E, DOI 10.1097/PRS.0000000000007677
   Tchero H, 2019, INDIAN J DERMATOL VE, V85, P248, DOI 10.4103/ijdvl.IJDVL_69_18
   Vaghela R, 2022, MICROCIRCULATION, V29, DOI 10.1111/micc.12742
   Walter AC, 2018, DERMATOL SURG, V44, P1323, DOI 10.1097/DSS.0000000000001668
NR 43
TC 9
Z9 9
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JUN 28
PY 2022
VL 9
AR 867487
DI 10.3389/fsurg.2022.867487
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2Z5ZT
UT WOS:000826656400001
PM 35836613
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, XY
   He, JQ
   Li, ZB
   Zhu, JY
   Wu, J
AF Wang, Xiaoyan
   He, Jinqing
   Li, Zhibin
   Zhu, Jiayuan
   Wu, Jun
TI The early association of water irrigation with negative pressure wound
   therapy does not more efficiently reduce the depth of the alkali
   infiltration progress into the burn
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE alkali burn; NPWT; water irrigation; wound healing
ID CHEMICAL BURNS; SKIN INJURIES
AB Water irrigation is an efficacious decontaminating method for dermis exposures to corrosive agents and hence has been widely applied to treat especially alkali burns. Nevertheless, once alkali has infiltrated the deep subcutaneous tissue, washing the tissue surface with water irrigation does not attenuate the damage progress. Therefore, significant efforts have been devoted to promising strategies aimed at removing the deeply infiltrated lye. According to a recent report, the negative pressure wound therapy (NPWT) reduces the pH value of the exudate from alkali-provoked burns thus accelerating wound healing. However, it remains to be ascertained whether or not NPWT coupled with water irrigation, that is, iNPWT, more effectively hinders the alkali injury deepening. In this study, we compared the effectiveness of an early application of water irrigation with or without NPWT in preventing the progressive deepening of the alkali burn in an animal model. Our histological examination results showed no appreciable difference in tissue injury depth, dermal retention, inflammatory cell infiltration, re-epithelization, and cellular function between iNPWT and water irrigation alone treatments. Thus, our results prove that the more expensive NPWT coupled with water irrigation does not more effectively hinder the alkali's injury deepening. Hence, iNPWT use should be more cautious in clinical practice.
C1 [Wang, Xiaoyan; Zhu, Jiayuan] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burn Surg, Guangzhou, Peoples R China.
   [He, Jinqing; Li, Zhibin; Wu, Jun] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Burn & Plast Surg,Shenzhen Inst Translat Med, Shenzhen 518035, Guangdong, Peoples R China.
   [Wu, Jun] Univ Verona, Dept Surg Dent Paediat & Obstet, Sect Human Histol & Embryol, Verona, Venetia, Italy.
C3 Sun Yat Sen University; Shenzhen University; University of Verona
RP Wu, J (通讯作者)，Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Burn & Plast Surg,Shenzhen Inst Translat Med, Shenzhen 518035, Guangdong, Peoples R China.; Zhu, JY (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510000, Guangdong, Peoples R China.
EM zhujiay@mail.sysu.edu.cn; junwupro@126.com
RI Li, Zhibin/GQH-6384-2022; Wang, Xiaoyan/M-7442-2018
OI wu, jun/0000-0002-4997-1970
FU Guangdong Basic and Applied Basic Research Foundation [2020A1515010613,
   2021A1515220176]; Guangdong Medical Science and Technology Research
   Foundation [A2021077]; National Natural Science Foundation of China
   [82172214, 82072180]; Retired Expert Program of Guangdong Province
   [202020031911500002]; Shenzhen-Hong Kong-Macau Technology Research
   Programme [SGDX2020110309300301]; Key Basic Research Project of Shenzhen
   Science and Technology Program [JCYJ20200109115635440]
FX Guangdong Basic and Applied Basic Research Foundation, Grant/Award
   Numbers: 2020A1515010613, 2021A1515220176; Guangdong Medical Science and
   Technology Research Foundation, Grant/Award Number:A2021077; National
   Natural Science Foundation of China, Grant/Award Numbers: 82172214,
   82072180; Retired Expert Program of Guangdong Province, Grant/Award
   Number: 202020031911500002; Shenzhen-Hong Kong-Macau Technology Research
   Programme, Grant/Award Number: SGDX2020110309300301; the Key Basic
   Research Project of Shenzhen Science and Technology Program, Grant/Award
   Number: JCYJ20200109115635440
CR Andrews K, 2003, PLAST RECONSTR SURG, V111, P1918, DOI 10.1097/01.PRS.0000058953.16695.A7
   Brent J, 2013, CLIN TOXICOL, V51, P731, DOI 10.3109/15563650.2013.838628
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NR 23
TC 0
Z9 0
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2023
VL 20
IS 2
BP 351
EP 358
DI 10.1111/iwj.13883
EA JUL 2022
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8K9TL
UT WOS:000827292700001
PM 35854477
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Reimer, S
   Seyfried, F
   Flemming, S
   Brand, M
   Weich, A
   Widder, A
   Plassmeier, L
   Kraus, P
   Döring, A
   Hering, I
   Hankir, MK
   Meining, A
   Germer, CT
   Lock, JF
   Groneberg, K
AF Reimer, Stanislaus
   Seyfried, Florian
   Flemming, Sven
   Brand, Markus
   Weich, Alexander
   Widder, Anna
   Plassmeier, Lars
   Kraus, Peter
   Doering, Anna
   Hering, Ilona
   Hankir, Mohammed K.
   Meining, Alexander
   Germer, Christoph-Thomas
   Lock, Johan F.
   Groneberg, Kaja
TI Evolution of endoscopic vacuum therapy for upper gastrointestinal
   leakage over a 10-year period: a quality improvement study
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Anastomotic leak; Gastrointestinal perforation; Esophageal perforation;
   Endoluminal; Vacuum-assisted closure; Negative pressure
ID ANASTOMOTIC LEAKAGE; ASSISTED CLOSURE; ESOPHAGECTOMY; CONSENSUS; SOCIETY
AB Background Endoscopic vacuum therapy (EVT) is an effective treatment option for leakage of the upper gastrointestinal (UGI) tract. The aim of this study was to evaluate the clinical impact of quality improvements in EVT management on patients' outcome. Methods All patients treated by EVT at our center during 2012-2021 were divided into two consecutive and equal-sized cohorts (period 1 vs. period 2). Over time several quality improvement strategies were implemented including the earlier diagnosis and EVT treatment and technical optimization of endoscopy. The primary endpoint was defined as the composite score MTL30 (mortality, transfer, length-of-stay > 30 days). Secondary endpoints included EVT efficacy, complications, in-hospital mortality, length-of-stay (LOS) and nutrition status at discharge. Results A total of 156 patients were analyzed. During the latter period the primary endpoint MTL30 decreased from 60.8 to 39.0% (P = .006). EVT efficacy increased from 80 to 91% (P = .049). Further, the need for additional procedures for leakage management decreased from 49.9 to 29.9% (P = .013) and reoperations became less frequent (38.0% vs.15.6%; P = .001). The duration of leakage therapy and LOS were shortened from 25 to 14 days (P = .003) and 38 days to 25 days (P = .006), respectively. Morbidity (as determined by the comprehensive complication index) decreased from 54.6 to 46.5 (P = .034). More patients could be discharged on oral nutrition (70.9% vs. 84.4%, P = .043). Conclusions Our experience confirms the efficacy of EVT for the successful management of UGI leakage. Our quality improvement analysis demonstrates significant changes in EVT management resulting in accelerated recovery, fewer complications and improved functional outcome.
C1 [Reimer, Stanislaus; Brand, Markus; Weich, Alexander; Kraus, Peter; Meining, Alexander; Groneberg, Kaja] Univ Hosp Wurzburg, Dept Gastroenterol, Wurzburg, Germany.
   [Flemming, Sven; Widder, Anna; Plassmeier, Lars; Doering, Anna; Hering, Ilona; Hankir, Mohammed K.; Germer, Christoph-Thomas; Lock, Johan F.] Univ Hosp Wurzburg, Dept Gen Visceral Transplant Vasc & Pediat Surg, Wurzburg, Germany.
   [Seyfried, Florian] Univ Hosp Wurzburg, Ctr Operat Med ZOM, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg; University of Wurzburg
RP Seyfried, F (通讯作者)，Univ Hosp Wurzburg, Ctr Operat Med ZOM, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Wurzburg, Germany.
EM Seyfried_F@ukw.de
RI Flemming, Sven/AAA-9950-2020; Weich, Alexander/ACW-1676-2022; Hankir,
   Mohammed/IZD-4807-2023; Lock, Johan/AAA-8114-2020
OI Meining, Alexander/0009-0001-3773-138X; Lock, Johan/0000-0002-9007-3937;
   Brand, Markus/0000-0002-3495-5206
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL. None.
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NR 25
TC 20
Z9 20
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD DEC
PY 2022
VL 36
IS 12
BP 9169
EP 9178
DI 10.1007/s00464-022-09400-w
EA JUL 2022
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6D1PZ
UT WOS:000827370700006
PM 35852622
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Bueno-Lledo, J
   Martinez-Hoed, J
   Pous-Serrano, S
AF Bueno-Lledo, Jose
   Martinez-Hoed, Jesus
   Pous-Serrano, Salvador
TI Negative pressure therapy in abdominal wall surgery
SO CIRUGIA ESPANOLA
LA English
DT Article
DE Negative pressure therapy; VAC (R); Hernia; Abdominal wall surgery; Mesh
   infection; Biofilm; Incisional therapy; Fascial traction
ID MEDIATED FASCIAL TRACTION; VACUUM-ASSISTED CLOSURE; WOUND THERAPY; OPEN
   ABDOMEN; MESH INFECTION; HERNIA REPAIR; RECONSTRUCTION; MANAGEMENT;
   GAUZE; FOAM
AB Negative pressure wound therapy (NPWT) is widely known in surgical practice. The initial indications for NPWT were chronic wounds, especially diabetic foot, vascular and decubitus ulcers, and infected traumatic wounds. Nowadays, the use has been widely increased. Although in the field of abdominal wall surgery, it has mainly been used in the treatment of surgical wound complications after hernia repair, other indications have been added after years of experience in the management of NPWT.
   Therefore, the aim of this article is to analyze and review the main indications of NPWT in abdominal wall surgery, as well as the advantages obtained with its application. (C) 2021 AEC. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Bueno-Lledo, Jose; Pous-Serrano, Salvador] Univ Valencia, Hosp Univ & Politecn La Fe, Unidad Cirugia Pared Abdominal, Valencia, Spain.
   [Martinez-Hoed, Jesus] Hosp Rafael Angel Calderon Guardia, San Jose, Costa Rica.
C3 Hospital Universitari i Politecnic La Fe; University of Valencia
RP Bueno-Lledo, J (通讯作者)，Univ Valencia, Hosp Univ & Politecn La Fe, Unidad Cirugia Pared Abdominal, Valencia, Spain.
EM buenolledo@hotmail.com
RI ; Bueno-Lledó, Jose/I-2674-2019
OI Pous-Serrano, Salvador/0000-0002-2931-0366; Bueno-Lledó,
   Jose/0000-0002-3116-5022
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NR 45
TC 2
Z9 8
U1 2
U2 7
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD AUG
PY 2022
VL 100
IS 8
BP 464
EP 471
DI 10.1016/j.ciresp.2021.12.006
EA JUL 2022
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3F3TC
UT WOS:000830592600002
PM 35584763
DA 2026-07-24
ER
PT J
AU Marrano, E
   Bunino, F
   Del Zotto, G
   Ceolin, M
   Mei, S
   Brocchi, A
   Kurihara, H
AF Marrano, Enrico
   Bunino, Francesca
   Del Zotto, Giulio
   Ceolin, Martina
   Mei, Simona
   Brocchi, Andrea
   Kurihara, Hayato
TI Open abdomen: is a dedicated emergency surgery team needed? A single
   center retrospective study on 141 consecutive patients
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE acute care surgery; emergency general surgery; open abdomen; septic
   abdomen
ID MANAGEMENT
AB Background Open Abdomen (OA) is widely used when facing a catastrophic abdomen. Still, no indication is validated by a strong and high quality of evidence. The study reports the 5 year experience of a dedicated emergency general surgery (EGS) team. Methods Retrospective observational cohort study. Patients undergoing OA management from 2/01/2015 to 19/07/2020 for trauma, non-traumatic emergencies or rescue surgery. Results One hundred and forty-one patients. Age 66.9 +/- 15.1. Male 58.2%.9.3% OA for trauma, 64.5% for non-traumatic emergencies and 26.2% for rescue surgery. 40.4% performed by the EGS team 52.4% indication for surgery was a severe intra-abdominal infection. TAC device: commercial negative pressure wound therapy (NPWT) (83%), Sandwich VAC (12%), commercial NPWT with polypropylene mesh (5%) for pregressive fascial traction. Enteroatmospheric fistula (EAF) in 3 patients. OA duration 5.3 days (1-25). A 1.8 revision surgeries (0-12) required for definitive closure; ICU stay 9.9 days (0-78). 30-day mortality 23.5%. Overall and 1-year mortality were 47.5% and 43.3%. Overall survival 9.9 months. An increased one-year mortality rate was found in the >65 group (P = 0.01). Conclusions We reported a wide use of OA in septic abdomen (90% of cases). We had a low rate of EAF, short ICU stay and OA duration. These results are related to the fact that patients were treated by a dedicated EGS team, suggesting that OA management should be cared for as much as possible by trained and experienced surgeons. Prospective studies with more accurate patient selection are needed to prove our conclusions.
C1 [Marrano, Enrico; Bunino, Francesca; Del Zotto, Giulio; Ceolin, Martina; Mei, Simona; Brocchi, Andrea] IRCCS Humanitas Res Hosp, Dept Gen Surg, Emergency Surg & Trauma Sect, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
   [Kurihara, Hayato] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Emergency Surg Unit, Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico
RP Marrano, E (通讯作者)，IRCCS Humanitas Res Hosp, Dept Gen Surg, Emergency Surg & Trauma Sect, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
EM dott.e.marrano@gmail.com
RI ; marrano, enrico/HTP-5057-2023; Brocchi, Andrea/PKG-9040-2026; Ceolin,
   Martina/HOF-2927-2023; Kurihara, Hayato/AAW-5550-2020
OI Brocchi, Anea/0000-0001-6707-8257; Bunino, Francesca
   Margherita/0000-0002-7600-9664; Del Zotto, Giulio/0000-0003-1346-8545;
   marrano, enrico/0000-0001-6818-0448; 
CR Beckman M, 2016, CRIT CARE CLIN, V32, P255, DOI 10.1016/j.ccc.2015.12.003
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NR 18
TC 3
Z9 6
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD SEP
PY 2022
VL 92
IS 9
BP 2213
EP 2217
DI 10.1111/ans.17949
EA JUL 2022
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 4M0GB
UT WOS:000832966800001
PM 35906883
DA 2026-07-24
ER
PT J
AU Ahmadzada, S
   Rao, A
   Ghazavi, H
AF Ahmadzada, Sejad
   Rao, Amshuman
   Ghazavi, Hossein
TI Necrotizing fasciitis of the face: current concepts in cause, diagnosis
   and management
SO CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
LA English
DT Review
DE deep neck infection; face abscess; necrotizing fasciitis
ID SOFT-TISSUE INFECTIONS; SURGICAL DEBRIDEMENT; NECK; HEAD;
   RECONSTRUCTION; CT
AB Purpose of review Necrotizing fasciitis of the face is uncommon but potentially life threatening. With adequate multidisciplinary treatment, mortality and has significantly improved. This article highlights current concepts and supporting literature in the management of facial necrotizing fasciitis. Recent findings Management of necrotizing fasciitis involving the face requires a multisciplinary team approach, including early medical and surgical intervention. With early haemodynamic support, broad spectrum antibiotics and aggressive surgical debridement, mortality has reduced significantly. Soft-tissue reconstruction can be effectively utilized once the infection has been adequately treated. Although some adjunctive treatment such as vacuum assisted closure dressing has shown to be of benefit, other treatments such as hyperbaric oxygen remains controversial. Necrotizing fasciitis is an aggressive soft tissue involving that rapidly spreads along fascial planes. Necrotizing fasciitis involving the face is rare owing to its rich blood supply but is also difficult to manage due to the complex regional anatomy. Common sources are odontogenic, sinugenic, peritonsillar or salivary gland infections and often polymicrobial. The principles of treatment include early and aggressive haemodynamic support, broad spectrum antibiotics and aggressive surgical debridement. Often times repeat debridements following close monitoring is required. Reconstructive options are viable only after the infection has been adequately treated. Although mortality has significantly improved, mediastinal involvement, multiple comorbidities and delayed treatment confers a worse prognosis.
C1 [Ahmadzada, Sejad; Rao, Amshuman] Univ Sydney, Sydney, NSW, Australia.
   [Ahmadzada, Sejad; Rao, Amshuman; Ghazavi, Hossein] John Hunter Hosp, Dept Otolaryngol, Lookout Rd, New Lambton Hts, NSW 2305, Australia.
C3 University of Sydney; John Hunter Hospital
RP Ghazavi, H (通讯作者)，John Hunter Hosp, Dept Otolaryngol, Lookout Rd, New Lambton Hts, NSW 2305, Australia.
EM h.ghazavi@gmail.com
OI Rao, Ahuman/0009-0006-5124-3346
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NR 48
TC 11
Z9 18
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1068-9508
EI 1531-6998
J9 CURR OPIN OTOLARYNGO
JI Curr. Opin. Otolaryngol. Head Neck Surg.
PD AUG
PY 2022
VL 30
IS 4
BP 270
EP 275
DI 10.1097/MOO.0000000000000820
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 3J0CS
UT WOS:000833073900014
PM 35906981
DA 2026-07-24
ER
PT J
AU Salmenkylä, T
   Kilpivaara, K
   Ohtonen, P
   Rautio, T
   Mäkäräinen, E
AF Salmenkyla, Tellu
   Kilpivaara, Katariina
   Ohtonen, Pasi
   Rautio, Tero
   Makarainen, Elisa
TI Case control study investigating the clinical utility of NPWT in the
   perineal region following abdominoperineal resection for rectal
   adenocarcinoma: a single center study
SO BMC SURGERY
LA English
DT Article
DE Abdominoperineal resection; Incisional negative-pressure wound therapy;
   Perineal reconstruction; Rectal adenocarcinoma
ID CANCER; THERAPY; CLOSURE
AB Background Perineal wound complications are common after abdominoperineal resection (APR) for rectal adenocarcinoma. Delayed wound healing may postpone postoperative adjuvant therapy and, therefore, lead to a worse survival rate. Negative-pressure wound therapy (NPWT) has been suggested to improve healing, but research on this subject is limited. Methods The aim of this study was to assess whether NPWT reduces surgical site infections (SSI) after APR for rectal adenocarcinoma when the closure is performed with a biological mesh and a local flap. A total of 21 consecutive patients had an NPWT device (Avelle, Convatec (TM)) applied to the perineal wound. The study patients were compared to a historical cohort in a case-control setting in relation to age, body mass index, tumor stage, and length of neoadjuvant radiotherapy. The primary outcome was the surgical site infection rate. The secondary outcomes were the wound complication rate, the severity of wound complications measured by the Clavien-Dindo classification, length of hospital stay, and surgical revision rate. Results The SSI rate was 33% (7/21) in the NPWT group and 48% (10/21) in the control group, p = 0.55. The overall wound complication rate was 62% (13/21) in NPWT patients and 67% (14/21) in the control group, p > 0.90. The length of hospital stay was 15 days in the NPWT group and 13 in the control group, p = 0.34. The wound severity according to the Clavien-Dindo classification was 3b in 29% (6/21) of the NPWT group and in 38% (8/21) of the control group. A surgical revision had to be performed in 29% (6/21) of the cases in the NPWT group and 38% (8/21) in the control group, p = 0.73. Conclusion NPWT did not statistically decrease surgical site infections or reduce wound complication severity in perineal wounds after APR in this case-control study. The results may be explained by technical difficulties in applying NPWT in the perineum, especially in female patients. NPWT devices should be further developed to suit the perineal anatomy before their full effect can be assessed. Trial registration The study was registered as a prospective registry study (266/2018, registered 15th of November 2018)
C1 [Salmenkyla, Tellu; Kilpivaara, Katariina; Rautio, Tero; Makarainen, Elisa] Oulu Univ Hosp, Med Res Ctr, Dept Surg, Oulu, Finland.
   [Ohtonen, Pasi] Oulu Univ Hosp, Res Serv Unit, Oulu, Finland.
   [Ohtonen, Pasi] Univ Oulu, Res Unit Surg Anesthesia & Intens Care, Oulu, Finland.
C3 University of Oulu; University of Oulu; University of Oulu
RP Salmenkylä, T (通讯作者)，Oulu Univ Hosp, Med Res Ctr, Dept Surg, Oulu, Finland.
EM tellu.salmenkyla@gmail.com
CR Biagi JJ, 2011, JAMA-J AM MED ASSOC, V305, P2335, DOI 10.1001/jama.2011.749
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NR 12
TC 3
Z9 3
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD JUL 30
PY 2022
VL 22
IS 1
AR 296
DI 10.1186/s12893-022-01746-1
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3J6HI
UT WOS:000833494000001
PM 35907824
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chen, XX
   Tang, QZ
   Luo, HB
   Zhong, XH
AF Chen, Xiaoxia
   Tang, Qingzhu
   Luo, Hongbiao
   Zhong, Xianghong
TI Intervention Effect of Evidence-Based Nursing on Postoperative Recovery
   of Vacuum Sealing Drainage in Patients with High Perianal Abscess with
   Magnetic Resonance Imaging Sequence Images
SO COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE
LA English
DT Article
AB The purpose of this study was to evaluate the intervention effect of evidence-based nursing (EBN) on vacuum sealing drainage (VSD) recovery of patients with high perianal abscess after vacuum sealing drainage based on magnetic resonance imaging (MRI) sequence images. 60 patients with high perianal abscess were selected, and 30 patients before VSD were selected as the control group. Routine nursing was implemented in the control group, 30 patients after VSD were observed, and EBN was implemented in the observation group. The detection rates of various types of perianal abscess with different sequence combinations were studied, and the effects of EBN on pain and anal function scores of perianal abscess patients were analyzed. Anal function and defecation were assessed, and postoperative complications were calculated. Different combinations of MRI sequences can reach higher detection rates of intersphincter abscess and ischial anal abscess. The observation group had better pain relief and anal function recovery. The complication rate of the observation group was 16.67%, which was significantly lower than that of the control group (P < 0.05). It was confirmed that different MRI sequence combinations had higher detection rates for intersphincter abscess and ischial fossa abscess. EBN can promote the recovery of anal function and reduce complications in patients with perianal abscess.
C1 [Chen, Xiaoxia; Tang, Qingzhu; Luo, Hongbiao; Zhong, Xianghong] Chenzhou First Peoples Hosp, Dept Anorectal Surg, Chenzhou 423000, Hunan, Peoples R China.
RP Zhong, XH (通讯作者)，Chenzhou First Peoples Hosp, Dept Anorectal Surg, Chenzhou 423000, Hunan, Peoples R China.
EM chenxiaoxiaxlng@163.com; tangqingzhugyx7@126.com;
   luohongbiaogznz@yeah.net; 201801110700064@stu.hubu.edu.cn
FU Chenzhou Science and Technology Bureau Project [lcyl2021062]
FX AcknowledgmentsThis work was supported by the Chenzhou Science and
   Technology Bureau Project (no. lcyl2021062).
CR Balaz K, 2020, POL J SURG, V92, P29, DOI 10.5604/01.3001.0013.8158
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   Wang JP, 2019, ANZ J SURG, V89, P244, DOI 10.1111/ans.14874
   Wang X, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019183
   Wu XM, 2022, J COSMET DERMATOL-US, V21, P2140, DOI 10.1111/jocd.14375
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   Yang J, 2021, CONTRAST MEDIA MOL I, V2021, DOI 10.1155/2021/9066128
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   Zhong ZF, 2019, EXP THER MED, V18, P1539, DOI 10.3892/etm.2019.7773
NR 24
TC 3
Z9 4
U1 0
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5265
EI 1687-5273
J9 COMPUT INTEL NEUROSC
JI Comput. Intell. Neurosci.
PD JUN 24
PY 2022
VL 2022
AR 1405134
DI 10.1155/2022/1405134
PG 7
WC Mathematical & Computational Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mathematical & Computational Biology; Neurosciences & Neurology
GA 3K6AJ
UT WOS:000834156700016
PM 35785101
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Kumbasar, U
   Bonde, P
AF Kumbasar, Ulas
   Bonde, Pramod
TI Shoelace technique for the management of deep sternal wound infection
SO TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND
   CARDIOVASCULAR SURGERY
LA English
DT Article
DE Infection; sternal wound; vacuum-assisted closure system
ID VACUUM-ASSISTED CLOSURE; FASCIOTOMY WOUNDS; THERAPY
AB In this article, we describe a practical technique of managing deep sternal wound infection by combining two dynamic wound closure methods, namely gradual approximation of the wound edges using vessel loops: the shoelace technique and the vacuum -assisted closure system.
C1 [Kumbasar, Ulas; Bonde, Pramod] Yale Univ, Dept Cardiothorac Surg, Sch Med, New Haven, CT 06525 USA.
C3 Yale University
RP Kumbasar, U (通讯作者)，Yale Univ, Dept Cardiothorac Surg, Sch Med, New Haven, CT 06525 USA.
EM ulaskumbasar@gmail.com
RI kumbasar, ulas/IVV-5351-2023
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   Fowler JR, 2012, BONE JOINT RES, V1, P31, DOI 10.1302/2046-3758.13.2000022
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NR 8
TC 0
Z9 0
U1 0
U2 5
PU BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
PI ATASEHIR
PA ORNEK MH DR SUPHI EZGI SK SARAY APT NO 11 D 6, ATASEHIR, ISTANBUL 34704,
   TURKEY
SN 1301-5680
J9 TURK GOGUS KALP DAMA
JI Turk Gogus Kalp Damar Cerrahisi Derg.
PD JUL
PY 2022
VL 30
IS 3
BP 469
EP 471
DI 10.5606/tgkdc.dergisi.2022.22025
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3M0XF
UT WOS:000835181100021
PM 36303688
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Wang, JM
   Yang, Y
   Xing, WQ
   Xing, H
   Bai, Y
   Chang, ZQ
AF Wang, Jingming
   Yang, Yang
   Xing, Wenqiang
   Xing, Hao
   Bai, Yun
   Chang, Zhengqi
TI Safety and efficacy of negative pressure wound therapy in treating deep
   surgical site infection after lumbar surgery
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
DE Surgical site infection (SSI); Clinical outcome; Negative pressure wound
   therapy (NPWT); Spinal instrumentation
ID VACUUM-ASSISTED CLOSURE; POSTERIOR SPINAL-FUSION; RISK-FACTORS;
   POSTOPERATIVE INFECTIONS; INSTRUMENTATION; IRRIGATION; DRAINAGE
AB Purpose To evaluate the efficacy and safety of negative pressure wound therapy (NPWT) for post-operative deep surgical site infection (SSI) after posterior instrumented spinal surgery. Methods We retrospectively compared the clinical outcomes of NPWT with standard debridement for deep SSI after posterior instrumented spinal surgery from 2012 to 2020 in our department. The primary outcomes were peri-operative characteristics including positive organism results, duration of fever, and visual analogue scale (VAS) pain scores three days after re-operation. The secondary outcomes were post-operative characteristics including implant infection recurrence, implant retention rate, duration of hospitalization, and VAS at discharge. Pearson's chi-squared analysis (categorical) and Student's t test (continuous) were used to determine the differences. Results Thirty-four patients were included, of which 19 underwent NPWT, and 15 underwent standard debridement. Patients in the NPWT group all significantly improved primary outcomes including duration of fever after re-operation (0.95 +/- 1.13 vs 4.07 +/- 5.35, P = 0.001), positive organism results (14 of 19 vs 2 of 15, P < 0.01), and VAS at 3 days after re-operation (2.58 +/- 0.69 vs 3.40 +/- 1.06, P < 0.05). Patients in NPWT group exhibited significant decrease in implant infection recurrence (0 of 19 vs 5 of 15, P < 0.01), implant retention rate (19 of 19 vs 10 of 15, P < 0.01), duration of hospitalization (27.74 +/- 10.95 vs 37.67 +/- 13.67, P < 0.01). Conclusions NPWT is a feasible and safe treatment option for deep SSI after posterior instrumented spinal surgery.
C1 [Wang, Jingming; Yang, Yang; Xing, Wenqiang; Xing, Hao; Bai, Yun; Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Shifan Rd, Jinan 250031, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Shifan Rd, Jinan 250031, Peoples R China.
EM 26766771@qq.com
RI Xing, Wenqiang/MBW-3134-2025; hao, xing/ACN-7926-2022; Wang,
   Jing-ming/JGW-2472-2023
OI Wang, Jing-ming/0000-0002-4499-2086
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NR 31
TC 17
Z9 19
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD NOV
PY 2022
VL 46
IS 11
BP 2629
EP 2635
DI 10.1007/s00264-022-05531-w
EA AUG 2022
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 5F7ZG
UT WOS:000836542200001
PM 35931831
DA 2026-07-24
ER
PT J
AU Meng, Z
   Wang, YC
   Chao, J
   Ji, YJ
   Sun, YF
   Zhu, J
   Gao, TB
   Chen, S
   Wang, SY
AF Meng, Zhe
   Wang, Yanchen
   Chao, Jun
   Ji, Yongjian
   Sun, Yaofei
   Zhu, Jiang
   Gao, Tongbin
   Chen, Si
   Wang, Shenyang
TI Extensive necrotizing fasciitis of scrotum and abdominal wall: Report of
   two cases and a review of the literature
SO FRONTIERS IN SURGERY
LA English
DT Review
DE necrotizing fasciitis; debridement; antibiotic; vacuum sealing
   draina(VSD)
ID PRESSURE WOUND THERAPY; DETERMINANTS; DIAGNOSIS
AB The incidence rate of necrotizing fasciitis(NF) is low, but it has a high mortality rate. At present, it lacks experience in clinical treatment in municipal and county-level hospitals, insufficient awareness of disease risk, lack of experience in disease surgical intervention, and lack of a set of mature treatment norms and standards. Most patients have no time to transfer to a higher hospital for treatment. In January and April 2022, two cases of large-scale necrotizing fasciitis of the scrotum and abdominal wall were treated in the Department of Urology of Weifang people's Hospital respectively and were clinically cured after active surgical debridement combined with broad-spectrum antibiotics. Through the retrospective analysis of the diagnosis and treatment of two cases of necrotizing fasciitis, this paper analyzes and summarizes the scope of surgical debridement of NF, postoperative dressing changing skills, timing of multiple debridements, application and timing of vacuum sealing drainage(VSD), and the combined use of antibiotics. To provide experience for clinical diagnosis and treatment of necrotizing fasciitis.
C1 [Meng, Zhe; Wang, Yanchen; Chao, Jun; Ji, Yongjian; Sun, Yaofei; Zhu, Jiang; Gao, Tongbin; Chen, Si; Wang, Shenyang] Weifang Med Coll, Yuhe Campus, Weifang, Peoples R China.
   [Meng, Zhe; Wang, Yanchen; Chao, Jun; Ji, Yongjian; Sun, Yaofei; Zhu, Jiang; Gao, Tongbin; Chen, Si; Wang, Shenyang] Weifang peoples Hosp, Dept Urol, Weifang, Peoples R China.
C3 Shandong Second Medical University; Shandong Second Medical University
RP Wang, SY (通讯作者)，Weifang Med Coll, Yuhe Campus, Weifang, Peoples R China.; Wang, SY (通讯作者)，Weifang peoples Hosp, Dept Urol, Weifang, Peoples R China.
EM 2009040210@st.btbu.edu.cn
RI chao, jun/GWU-8430-2022; meng, zhe/GWQ-8413-2022
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NR 25
TC 3
Z9 5
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JUL 19
PY 2022
VL 9
AR 952042
DI 10.3389/fsurg.2022.952042
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3O6KW
UT WOS:000836945000001
PM 35928030
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, N
   Li, SS
   Liu, YP
   Peng, YY
   Wang, PF
AF Wang, Nan
   Li, Shuang-Shuang
   Liu, Ya-Ping
   Peng, Ying-Ying
   Wang, Peng-Fei
TI Comparison of negative pressure wound therapy and moist wound care in
   patients with diabetic foot ulcers: A protocol for systematic review and
   meta-analysis of randomized controlled trials
SO MEDICINE
LA English
DT Review
DE diabetic foot ulcer; meta-analysis; moist wound care; negative pressure
   wound therapy
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; PREVALENCE; MELLITUS
AB Background: This study conducted a meta-analysis to compare the effectiveness and safety of the negative pressure wound therapy (NPWT) with the moist wound care (MWC) in the treatment of diabetic foot ulcers (DFUs). Methods: The PubMed, EMBASE, and CENTRAL were searched by 2 of the authors, to identify randomized controlled trials comparing the clinical outcomes of patients treated with NPWT versus MWC for DFUs. Meta-analyses were performed for several outcomes, including wound healing results, amputation or resection incidence, and risk of adverse events, utilizing the "meta" package of R language version 4.0.3. Results: A total of 10 trials (619 patients in NPWT group and 625 in MWC group) and 8 trials were included for the qualitative and quantitative syntheses, respectively. As a result, significantly lower risk of non-closure of the wound (risk ratio [RR] = 0.74, 95% confidence interval [CI]: 0.63-0.87; P = .001), lower average wound area (standard mean difference = -0.80, 95% CI: -1.54 to -0.06; P = .034), more wound area decrease (standard mean difference = 0.81, 95% CI: 0.36-1.26; P = .001), increased appearance rate of granulation tissue (RR = 1.61, 95% CI: 1.07-2.41; P-0.021), and lower risk of amputation or resection (RR = 0.70, 95% CI: 0.50-0.99; P = .045), were demonstrated for the NPWT group when compared to MWC group. However, no statistically significant difference was found for the disappearance rate of wound discharge at 8 weeks, the rate of blood culture positivity, VAS-pain score, and the overall frequency of adverse events between the 2 treatment groups (P = .05). Conclusion: NPWT could accelerate process of the wound healing, and decrease the risk of post-treatment amputation or resection, without any additional frequency of adverse events, when compared with MWC, in patients with DFUs.
C1 [Wang, Nan; Li, Shuang-Shuang; Liu, Ya-Ping; Peng, Ying-Ying; Wang, Peng-Fei] Cangzhou Cent Hosp, 16 Xinhua Western Rd, Cangzhou City 061000, Hebei, Peoples R China.
RP Wang, PF (通讯作者)，Cangzhou Cent Hosp, 16 Xinhua Western Rd, Cangzhou City 061000, Hebei, Peoples R China.
EM wangpengfei112233@yeah.net; lishuangshuang2021@163.com;
   liuyapingcangzhou@yeah.net; pengyingyingpyy@163.com;
   wangpengfei112233@yeah.net
RI Wang, Pengfei/AAN-8797-2020
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NR 23
TC 3
Z9 6
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG 5
PY 2022
VL 101
IS 31
AR e29537
DI 10.1097/MD.0000000000029537
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3P8IJ
UT WOS:000837777500008
PM 35945751
OA Green Published, gold
DA 2026-07-24
ER
PT J
AU Pan, SF
   Xiong, L
   Wang, ZJ
   Su, YJ
   Fang, GF
   Zhu, MD
   Wang, J
   Shi, HQ
   Zhu, SH
   Shi, YB
AF Pan, Sunfeng
   Xiong, Lie
   Wang, Zhenjun
   Su, Yujuan
   Fang, Gaofeng
   Zhu, Minda
   Wang, Jing
   Shi, Hanqiang
   Zhu, Shihui
   Shi, Yanbo
TI Therapeutic Effect and Mechanism of Negative Pressure Wound Therapy with
   Huoxue Shengji Decoction Instillation for Chronic Skin Ulcers
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ENDOTHELIAL GROWTH-FACTOR; ANGIOGENESIS; VEGF
AB Background. Negative pressure wound therapy (NPWT) with instillation (NPWTi) is a new treatment for chronic skin ulcers (CSUs), but the choice of perfusate is still investigated. The clinical application of Huoxue Shengji (HXSJ) decoction has been proved to promote the formation of granulation. The formation of fresh granulation, angiogenesis, and proliferation of vascular endothelial cells are closely related. The purpose of this study was to observe the clinical efficacy of NWPT with HXSJ decoction instillation in the treatment of CSUs and to explore the potential mechanism by which HXSJ decoction promotes proliferation of vascular endothelial cells at the cellular level. Methods. In the clinical study, the random number table was used to divide the patients into three groups (patients were numbered by visit time and assigned a random number and grouped by the remainder after the random number was divided by 3, and when the number of patients in one group reached 20, the enrolment of this group is stopped), including NPWT combined with HXSJ decoction instillation (group A), NPWT combined with normal saline instillation (group B), and NPWT (group C). Related indexes were examined, including the wound cavity volume, bacterial culture, histopathology examination, time periods of debridement, repair methods, and the time of ulcer healing. In the basic research, the effect of HXSJ decoction on the proliferation of HUVECs was analysed by CCK-8 assay and RT-PCR and western blot were used to quantify the VEGF and VEGFR-2 expression in the relevant signalling pathway. Results. There was no significant difference in the improvement rate of invasive cavity volume (P>0.05) between groups A and B, but a significant difference was observed between groups A and C (P<0.05). There was no significant difference in microbial reduction among groups (all P>0.05). Histopathological examination showed that the microvascular count in group A was significantly higher than that in groups B and C (both P<0.01) and there was no statistical difference between groups B and C (P>0.05). There were no significant differences in the number of invasive lesions and repair methods among the groups (all P>0.05). The healing time of group A was significantly faster than those of groups B and C (compared to group B, P<0.05; compared to group C, P<0.01), and there was no statistical difference between groups B and C (P>0.05). In the cellular experiments, concentration screening was performed and 125 mu g/mL HXSJ decoction showed the most significant effect on the proliferation of HUVECs and also enhanced the expression of VEGF and VEGFR-2. Conclusion. HXSJ decoction can enhance the expression of VEGF and VEGFR-2 and promote the proliferation of HUVECs. Treatment with NWPT with HXSJ decoction instillation can further reduce the wound cavity volume; meanwhile, it can promote blood vessel formation in ulcer wounds, thus accelerating the healing of CSUs.
C1 [Pan, Sunfeng; Wang, Zhenjun; Su, Yujuan; Fang, Gaofeng; Zhu, Minda; Wang, Jing] Zhejiang Chinese Med Univ, Dept Burns & Plast Surg, Jiaxing TCM Hosp, Jiaxing, Zhejiang, Peoples R China.
   [Pan, Sunfeng; Xiong, Lie; Wang, Zhenjun; Su, Yujuan; Fang, Gaofeng; Zhu, Minda; Wang, Jing; Shi, Hanqiang; Shi, Yanbo] Jiaxing Key Lab Diabet Angiopathy Res, Jiaxing, Zhejiang, Peoples R China.
   [Pan, Sunfeng; Wang, Zhenjun; Su, Yujuan; Fang, Gaofeng; Zhu, Minda; Wang, Jing] Jiaxing Burn & Wound Repair Therapy Ctr, Jiaxing, Zhejiang, Peoples R China.
   [Xiong, Lie; Shi, Hanqiang; Shi, Yanbo] Zhejiang Chinese Med Univ, Cent Lab Mol Med Res Ctr, Jiaxing TCM Hosp, Jiaxing, Zhejiang, Peoples R China.
   [Zhu, Shihui] Naval Med Univ, Changhai Hosp, Dept Burns Surg, Shanghai, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Naval Medical University
RP Shi, YB (通讯作者)，Jiaxing Key Lab Diabet Angiopathy Res, Jiaxing, Zhejiang, Peoples R China.; Shi, YB (通讯作者)，Zhejiang Chinese Med Univ, Cent Lab Mol Med Res Ctr, Jiaxing TCM Hosp, Jiaxing, Zhejiang, Peoples R China.; Zhu, SH (通讯作者)，Naval Med Univ, Changhai Hosp, Dept Burns Surg, Shanghai, Peoples R China.
EM doctorzhushihui@163.com; shiyanbocas@163.com
RI Xiong, Lie/HJI-5642-2023; Shi, Hanqiang/ODJ-9915-2025
FU Public Welfare Technology Applied Research Projects in Zhejiang Province
   [LGF21H270009]; Zhejiang Science and Technology Program of Traditional
   Chinese Medicine [2020ZB251, 2018ZB126]; Zhejiang Medical and Health
   Science and Technology Program [2019KY702]; Project of Science and
   Technology Innovation for People's livelihood of Jiaxing [2018AY32032]
FX THe authors thank the nursing department and related nursing staff that
   assisted us in the course of clinical research. -e authors thank Mr.
   Pufan Zhou for technical assistance. -is work was supported by the
   Public Welfare Technology Applied Research Projects in Zhejiang Province
   (LGF21H270009), Zhejiang Science and Technology Program of Traditional
   Chinese Medicine (2020ZB251), Zhejiang Medical and Health Science and
   Technology Program (2019KY702), Project of Science and Technology
   Innovation for People's livelihood of Jiaxing (2018AY32032), and
   Zhejiang Science and Technology Program of Traditional Chinese Medicine
   (2018ZB126).
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NR 29
TC 2
Z9 3
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUN 22
PY 2022
VL 2022
AR 5183809
DI 10.1155/2022/5183809
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 3R1TC
UT WOS:000838701200004
PM 35783525
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Biancari, F
   Santoro, G
   Provenzano, F
   Savarese, L
   Iorio, F
   Giordano, S
   Zebele, C
   Speziale, G
AF Biancari, Fausto
   Santoro, Grazia
   Provenzano, Federica
   Savarese, Leonardo
   Iorio, Francesco
   Giordano, Salvatore
   Zebele, Carlo
   Speziale, Giuseppe
TI Negative-Pressure Wound Therapy for Prevention of Sternal Wound
   Infection after Adult Cardiac Surgery: Systematic Review and
   Meta-Analysis
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE sternal wound infection; surgical site infection; negative-pressure
   wound therapy; pico; prevena; avelle; vivanotec
ID INCISION MANAGEMENT; RISK; COST
AB The results of current studies are not conclusive on the efficacy of incisional negative-pressure wound therapy (NPWT) for the prevention of sternal wound infection (SWI) after adult cardiac surgery. A systematic review of the literature was performed through PubMed, Scopus and Google to identify studies which investigated the efficacy of NPWT to prevent SWI after adult cardiac surgery. Available data were pooled using RevMan and Meta-analyst with random effect models. Out of 191 studies retrieved from the literature, ten fulfilled the inclusion criteria and were included in this analysis. The quality of these studies was judged fair for three of them and poor for seven studies. Only one study was powered to address the efficacy of NPWT for the prevention of postoperative SWI. Pooled analysis of these studies showed that NPWT was associated with lower risk of any SWI (4.5% vs. 9.0%, RR 0.54, 95% CI 0.34-0.84, I-2 48%), superficial SWI (3.8% vs. 4.4%, RR 0.63, 95% CI 0.29-1.36, I-2 65%), and deep SWI (1.8% vs. 4.7%, RR 0.46, 95% CI 0.26-0.74, I-2 0%), but such a difference was not statistically significant for superficial SWI. When only randomized and alternating allocated studies were included, NPWT was associated with a significantly lower risk of any SWI (3.3% vs. 16.5%, RR 0.22, 95% CI 0.08-0.62, I-2 0%), superficial SWI (2.6% vs. 12.4%, RR 0.21, 95% CI 0.06-0.69, I-2 0%), and deep SWI (1.2% vs. 4.8%, RR 0.17, 95% CI 0.03-0.95, I-2 0%). This pooled analysis showed that NPWT may prevent postoperative SWI after adult cardiac surgery. NPWT is expected to be particularly useful in patients at risk for surgical site infection and may significantly reduce the burden of resources needed to treat such a complication. However, the methodology of the available studies was judged as poor for most of them. Further studies are needed to obtain conclusive results on the potential benefits of this preventative strategy.
C1 [Biancari, Fausto; Santoro, Grazia; Provenzano, Federica; Savarese, Leonardo; Iorio, Francesco; Giordano, Salvatore; Zebele, Carlo] GVM Care & Res, Clin Montevergine, I-83013 Mercogliano, Italy.
   [Biancari, Fausto] Univ Helsinki, Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki 00029, Finland.
   [Speziale, Giuseppe] Anthea Hosp, GVM Care & Res, I-70124 Bari, Italy.
C3 University of Helsinki; Helsinki University Central Hospital
RP Biancari, F (通讯作者)，GVM Care & Res, Clin Montevergine, I-83013 Mercogliano, Italy.; Biancari, F (通讯作者)，Univ Helsinki, Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki 00029, Finland.
EM faustobiancari@yahoo.it; leonardosavarese@libero.it; federfarma@live.it;
   leonardosavarese@libero.it; aorticaortic@gmail.com;
   salvatoregiordano970@libero.it; carlo.zebele@gmail.com;
   gspeziale@gvmnet.it
RI Biancari, Fausto/A-1039-2008; Iorio, Francesco/JQI-8555-2023
OI Biancari, Fausto/0000-0001-5028-8186; 
CR Ariyaratnam P, 2010, INTERACT CARDIOV TH, V11, P543, DOI 10.1510/icvts.2010.237883
   Biancari F, 2020, INFECT CONT HOSP EP, V41, P444, DOI 10.1017/ice.2019.375
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   Myllykangas HM, 2022, THORAC CARDIOV SURG, V70, P65, DOI 10.1055/s-0041-1731767
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NR 24
TC 18
Z9 23
U1 0
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2022
VL 11
IS 15
AR 4268
DI 10.3390/jcm11154268
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3R9BQ
UT WOS:000839200300001
PM 35893360
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jansen, KT
   Hetzel, J
   Schulte, C
   Düzenli, N
   Fusco, S
   Zerabruck, E
   Schmider, E
   Malek, NP
   Königsrainer, A
   Stüker, D
   Werner, CR
   Wichmann, D
AF Jansen, Kai Tobias
   Hetzel, Juergen
   Schulte, Carola
   Duezenli, Nurgul
   Fusco, Stefano
   Zerabruck, Emanuel
   Schmider, Eva
   Malek, Nisar P.
   Koenigsrainer, Alfred
   Stueker, Dietmar
   Werner, Christoph R.
   Wichmann, Doerte
TI Differences in fluid removal of different open-pore elements for
   endoscopic negative pressure therapy in the upper gastrointestinal tract
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE; DRAINAGE
AB Endoscopic negative pressure therapy is an effective treatment strategy for various defects of the gastrointestinal tract. The functional principle is based on an open-pore element, which is placed around a perforated drainage tube and connected to a vacuum source. The resulting open-pore suction device can undergo endoluminal or intracavitary placement. Different open-pore suction devices are used for endoscopic negative pressure therapy of upper gastrointestinal tract defects. Comparative analyses for features and properties of these devices are still lacking. Eight different (six hand-made devices and two commercial devices) open-pore suction devices for endoscopic negative pressure therapy of the upper gastrointestinal tract were used, amount fluid removed was evaluated. The evaluation parameters included the time to reach the target pressure, the time required to remove 100 ml of water, and the material resistance of the device. All open-pore suction devices are able to aspirate the target volume of fluids. The time to reach the target volume varied considerably. Target negative pressure was not achieved with all open-pore suction devices during the aspiration of fluids; however, there was no negative effect on suction efficiency. Of the measurement data, material resistance could be calculated for six open-pore elements. We present a simple experimental, nonphysiologically setup for open-pore suction devices used for endoscopic negative pressure therapy. The expected quantity of fluids secreted into the treated organs should affect open-pore suction device for endoscopic negative pressure therapy.
C1 [Jansen, Kai Tobias; Schulte, Carola; Duezenli, Nurgul; Koenigsrainer, Alfred; Stueker, Dietmar; Wichmann, Doerte] Univ Hosp Tubingen, Dept Gen Visceral & Transplantat Surg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
   [Hetzel, Juergen] Univ Hosp Tubingen, Dept Internal Med Pulmonol & Oncol 8, Otfried Muller Str 10, D-72076 Tubingen, Germany.
   [Hetzel, Juergen] Cantonal Hosp Winterthur, Dept Internal Med, Devis Pulmonol, Brauer Str 15, CH-8400 Winterthur, Switzerland.
   [Fusco, Stefano; Malek, Nisar P.; Werner, Christoph R.] Univ Hosp Tubingen, Dept Internal Med Gastroenterol Hepatol Gastroint, Otfried Mueller Str 10, D-72076 Tubingen, Germany.
   [Hetzel, Juergen; Fusco, Stefano; Zerabruck, Emanuel; Schmider, Eva; Malek, Nisar P.; Koenigsrainer, Alfred; Stueker, Dietmar; Werner, Christoph R.; Wichmann, Doerte] Univ Hosp Tubingen, Interdisciplinary Endoscop Unit, Hoppe Seyler Str 6, D-72076 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital; Eberhard Karls University of Tubingen; Eberhard
   Karls University Hospital; Eberhard Karls University of Tubingen;
   Eberhard Karls University Hospital
RP Werner, CR (通讯作者)，Univ Hosp Tubingen, Dept Internal Med Gastroenterol Hepatol Gastroint, Otfried Mueller Str 10, D-72076 Tubingen, Germany.; Werner, CR (通讯作者)，Univ Hosp Tubingen, Interdisciplinary Endoscop Unit, Hoppe Seyler Str 6, D-72076 Tubingen, Germany.
EM christoph.werner@med.uni-tuebingen.de
RI ; Fusco, Stefano/JYQ-3117-2024
OI Hetzel, Juergen/0009-0008-7668-0723; Fusco, Stefano/0000-0001-6093-4567
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
CR Archid R, 2020, OBES SURG, V30, P1310, DOI 10.1007/s11695-019-04269-6
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NR 20
TC 5
Z9 7
U1 0
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 16
PY 2022
VL 12
IS 1
AR 13889
DI 10.1038/s41598-022-17700-3
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 3V1BY
UT WOS:000841397200025
PM 35974057
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Xu, YJ
   Gao, X
   Ding, H
   Bu, XM
   Wang, HB
   Wu, B
AF Xu, Ying-Jie
   Gao, Xu
   Ding, Hao
   Bu, Xian-Min
   Wang, Hai-Bin
   Wu, Bin
TI Effects of 1-stage revascularization and temporary external fixation
   combined with 2-stage Ilizarov technique in the treatment of bone
   defects in lower limb destruction injury: A case report
SO MEDICINE
LA English
DT Article
DE external fixation; Ilizarov bone transport; limb bone defect;
   reascularization
ID FRACTURES; TRANSPORT; MANAGEMENT
AB Rationale: To evaluate the clinical effects of 1-stage revascularization, vacuum sealing drainage covering the wound, temporary external fixation and 2-stage Ilizarov bone transport for the treatment limb destruction injury. Patient concerns and diagnosis: Nine patients with limb destruction injury between September 2014 and June 2019 at our institute were evaluated retrospectively. The age of patient was 21 to 51 years with an average of 33 years. The injuries were caused by vehicle accidents in 4 patients, gunshot in 1 patient, and crushing injuries in 4 patients. All of them had vascular injury. The average length of bone defect was 9.5 (8.3-10) cm. Regular follow-up was performed on wound healing, bone transport time, bone healing time, external fixation index, and limb function. Interventions: All patients underwent 1-stage revascularization and temporary external fixation during emergency surgery, and then gradual bone transport by Ilizarov fixator was performed until the broken fracture site was reunited. Outcomes: Nine patients were followed up for 12 to 48 months (average 30 months). Six patients were treated with autogenous cancellous bone graft for the second time, and 2 patients healed spontaneously. The mean wound healing time was 86 (73-90) days. The bone transport time was 97 (88.3-105.3) days, and the bone mineralization time was 164.5 (156.8-181.3) days, and the healing time of the docking sites was 6.8 (6.1-8.3) months. The external fixator time was 14.5 (12.5-17) months with the external fixation index was 1.5 (1.4-1.8) m/cm. At the last follow-up, according to the Association for the Study of the Method of Ilizarov functional scores, excellent functional outcomes were obtained in 5 patients, good in 1 patients, moderate in 2 patients. According to the Association for the Study of the Method of Ilizarov Radiological System, excellent functional outcomes were obtained in 6 cases and good in 2 cases. Lessons: One-stage revascularization and temporary external fixation combined with 2-stage Ilizarov bone transport technique for the treatment of bone defects in limb destruction injury have satisfactory clinical effects and few complications, and can be applied under the condition of strict understanding of surgical indications.
C1 [Xu, Ying-Jie; Ding, Hao] Jining Med Univ, Dept Clin Med, Jining City, Peoples R China.
   [Gao, Xu] Qingdao Univ, Dept Qingdao Med Coll, Qingdao, Peoples R China.
   [Bu, Xian-Min] Jining 1 Peoples Hosp, Dept Pathol, Jining City, Peoples R China.
   [Wang, Hai-Bin; Wu, Bin] Jining Med Univ, Dept Orthoped, Affiliated Hosp, 89 Guhual Rd, Jining City 272029, Shandong, Peoples R China.
C3 Jining Medical University; Qingdao University; Jining Medical University
RP Wu, B (通讯作者)，Jining Med Univ, Dept Orthoped, Affiliated Hosp, 89 Guhual Rd, Jining City 272029, Shandong, Peoples R China.
EM wb0902@163.com
FU "Jining Medical University Helin Academician Fund" [JYHL2018FMS13];
   "Supporting Fund for Teachers' Research at Jining Medical University
   [JYFC2018FKJ048]; "Jining Science and Technology Bureau Medical Health
   Fund" [2018SMNS002]; Cultivation plan of high-level scientific research
   project of Jining Medical University [JYGC2021FKJ016]; Jining key
   research and development project [2021YXNS029]
FX This study was supported by the "Jining Medical University Helin
   Academician Fund" (grant number JYHL2018FMS13), the "Supporting Fund for
   Teachers' Research at Jining Medical University" (grant number
   JYFC2018FKJ048), the "Jining Science and Technology Bureau Medical
   Health Fund" (grant number 2018SMNS002), Cultivation plan of high-level
   scientific research project of Jining Medical University
   (JYGC2021FKJ016), Jining key research and development project
   (2021YXNS029).
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NR 18
TC 1
Z9 2
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG 19
PY 2022
VL 101
IS 33
AR e30149
DI 10.1097/MD.0000000000030149
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3V8UT
UT WOS:000841935100074
PM 35984144
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Agarwal, A
AF Agarwal, Animesh
TI Evolution of Negative Pressure Wound Therapy in Orthopaedic Trauma
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy; incisional negative pressure wound
   therapy; orthopaedic trauma; open fractures; closed incisions; active
   incision management; instillation and distillation wound therapy
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISIONS; OPEN FRACTURES; INFECTION;
   RISK; INSTILLATION; COVERAGE; INJURY
AB Negative Pressure Wound Therapy (NPWT) has evolved from open wound management to now include closed incision management. It has been a major advance in the management of open wounds and closed incisional wounds especially in orthopaedic trauma surgery. Because of the success of NPWT in the late 1990s and early 2000s, surgeons began using NPWT with adjuncts on closed incisions as a way to help prevent surgical wound dehiscence especially in at-risk patients for wound problems. It has been well established that obesity, diabetes, and smoking in addition to other comorbidities increase the risk of wound dehiscence and surgical site infections in orthopaedic patients. It is widely used for open wound management, often associated with open fractures, and in the mitigation of risk of surgical site infections over closed incisions (incisional negative pressure wound therapy). Newer systems allow the use of various topical wound solutions to be instilled in conjunction with NPWT, termed NPWTi-d. This has shown promising results in difficult wounds that may be resistant to standard NPWT. This article reviews the evolution and use of NPWT in orthopaedic trauma.
C1 [Agarwal, Animesh] Univ Texas Hlth Sci Ctr San Antonio, Dept Orthopaed, Div Orthopaed Trauma, 7703 Floyd Curl Dr,MC7774, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas at San Antonio
RP Agarwal, A (通讯作者)，Univ Texas Hlth Sci Ctr San Antonio, Dept Orthopaed, Div Orthopaed Trauma, 7703 Floyd Curl Dr,MC7774, San Antonio, TX 78229 USA.
EM agarwal@uthscsa.edu
RI Agarwal, Animesh/AAG-5725-2020
OI Agarwal, Animesh/0000-0003-3287-3052
CR Allegranzi Benedetta, 2016, Lancet Infect Dis, V16, pe276, DOI [10.1016/s1473-3099(16)30402-9, 10.1016/s1473-3099(16)30398-x, 10.1016/S1473-3099(16)30398-X]
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NR 38
TC 5
Z9 7
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2022
VL 36
SU 4
BP S1
EP S5
DI 10.1097/BOT.0000000000002431
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 3Y2NF
UT WOS:000843564400002
PM 35994301
DA 2026-07-24
ER
PT J
AU Van Rysselberghe, NL
   Gonzalez, CA
   Calderon, C
   Mansour, A
   Oquendo, YA
   Gardner, MJ
AF Van Rysselberghe, Noelle L.
   Gonzalez, Christian A.
   Calderon, Christian
   Mansour, Adam
   Oquendo, Yousi A.
   Gardner, Michael J.
TI Negative Pressure Wound Therapy for Extremity Open Wound Management: A
   Review of the Literature
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Review
DE negative pressure; wound vac; open fractures; soft tissue reconstruction
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; BACTERIAL LOAD; OPEN
   FRACTURES; DRESSINGS; GROWTH; NPWT
AB Negative pressure wound therapy (NPWT) with reticulated open cell foam is used commonly in orthopaedic trauma, particularly in the management of complex open fracture wounds. This article reviews the literature to date regarding this adjunctive treatment, particularly in regard to removal of infectious material, temporary management of wounds pending soft tissue reconstruction, combat wounds, and over split-thickness skin grafts. Mechanism of action is also reviewed, including stabilization of the wound environment, edema control, macrodeformation, and microdeformation effects. Use of NPWT as an adjunct in management of open fractures along with operative debridement, systemic antibiotics, and early soft tissue reconstruction are the highest yield interventions for managing open fracture wounds with infection. NPWT as an adjunct therapy in the protocol for open fractures seems to add additional clinical benefit for patients with severe open fracture wounds not amenable to primary, immediate closure.
C1 [Van Rysselberghe, Noelle L.; Calderon, Christian; Oquendo, Yousi A.; Gardner, Michael J.] Stanford Univ, Dept Orthopaed Surg, 300 Pasteur Dr,Edwards Bldg,R144, Stanford, CA 94305 USA.
   [Gonzalez, Christian A.] Univ Nevada, Sch Med, Reno Sch Med, Reno, NV 89557 USA.
   [Mansour, Adam] Northeast Ohio Med Univ, Sch Med, Rootstown, OH USA.
C3 Stanford University; Stanford Medicine; Nevada System of Higher
   Education (NSHE); University of Nevada Reno; University System of Ohio;
   Northeast Ohio Medical University (NEOMED)
RP Van Rysselberghe, NL (通讯作者)，Stanford Univ, Dept Orthopaed Surg, 300 Pasteur Dr,Edwards Bldg,R144, Stanford, CA 94305 USA.
EM nvanry@stanford.edu
OI Van Rysselberghe, Noelle/0000-0001-8748-9547; Mansour,
   Adam/0009-0008-8389-5845
CR Arti H, 2016, PAK J MED SCI, V32, P65, DOI 10.12669/pjms.321.8568
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   Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
   Burtt KE, 2020, J SURG RES, V247, P499, DOI 10.1016/j.jss.2019.09.055
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   Patmo ASP, 2014, ADV WOUND CARE, V3, P383, DOI 10.1089/wound.2013.0510
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   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
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   Stinner DJ, 2011, J TRAUMA, V71, pS147, DOI 10.1097/TA.0b013e318221944a
   Streubel PN, 2012, J AM ACAD ORTHOP SUR, V20, P564, DOI 10.5435/JAAOS-20-09-564
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   WAKE MC, 1994, CELL TRANSPLANT, V3, P339, DOI 10.1177/096368979400300411
NR 35
TC 8
Z9 12
U1 2
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2022
VL 36
SU 4
BP S6
EP S11
DI 10.1097/BOT.0000000000002430
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 3Y2NF
UT WOS:000843564400003
PM 35994302
DA 2026-07-24
ER
PT J
AU Kim, P
AF Kim, Paul
TI Negative Pressure Wound Therapy With Instillation: An Adjunctive Therapy
   for Infection Management in Orthopaedic Trauma
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy with instillation; NPWTi-d; negative
   pressure wound therapy; NPWT; infection; bacteria; orthopaedic trauma;
   antimicrobial; antiseptic; wound; biofilm; irrigation
ID SURGICAL SITE INFECTION; RISK-FACTORS; BIOBURDEN; FIXATION; STANDARD;
   SALINE
AB Negative Pressure Wound Therapy with Instillation is a device that provides the benefits of standard negative pressure wound therapy and instillation of a topical wound solution. This combination can benefit acute and chronic wounds by continuously cleansing the wound and providing soft tissue stability between staged operations or in preparation for a single procedure. Although skeletal stability is important in orthopaedic trauma, the overlying soft tissue envelop may also be compromised, which can lead to contamination and infection. This review will discuss the growing body of evidence for the use of negative pressure wound therapy with instillation with a focus on infection and recommendations for its proper use.
C1 [Kim, Paul] Univ Texas Southwestern, Dept Plast Surg, Dallas, TX 75390 USA.
   [Kim, Paul] Univ Texas Southwestern, Dept Orthoped Surg, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas Southwestern
   Medical Center
RP Kim, P (通讯作者)，Univ Texas Southwestern, Dept Plast Surg, Dallas, TX 75390 USA.; Kim, P (通讯作者)，Univ Texas Southwestern, Dept Orthoped Surg, Dallas, TX 75390 USA.
OI , Paul/0000-0002-6186-6890
CR Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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   Gabriel Allen, 2014, Surg Technol Int, V24, P75
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   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2018, WOUNDS, pS1
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
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   Kim PJ, 2015, Wounds, V27, pS2
   Liu J, 2021, PLAST RECONSTR SURG, V147, p54S, DOI 10.1097/PRS.0000000000007622
   McKanna M, 2016, OSTOMY WOUND MANAG, P3
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Shao JS, 2018, INT J SURG, V56, P124, DOI 10.1016/j.ijsu.2018.06.018
   Shao JS, 2017, INT J SURG, V41, P176, DOI 10.1016/j.ijsu.2017.03.085
   Streubel PN, 2012, J AM ACAD ORTHOP SUR, V20, P564, DOI 10.5435/JAAOS-20-09-564
   Yang C, 2017, WOUNDS, V29, P240
NR 25
TC 1
Z9 2
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2022
VL 36
SU 4
BP S12
EP S16
DI 10.1097/BOT.0000000000002428
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 3Y2NF
UT WOS:000843564400004
PM 35994303
DA 2026-07-24
ER
PT J
AU Duda, M
   Kim, P
AF Duda, Marcus
   Kim, Paul
TI Negative Pressure Wound Therapy With Instillation-Dwell in Orthopaedic
   Trauma: How to Avoid Leaks and Frustration
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell; negative
   pressure wound therapy; adhesive; acrylic drapes; foam dressing;
   silicone drapes; hydrophilic dressing
ID SALINE; ADHESIVE
AB Negative pressure wound therapy with instillation-dwell (NPWTi-d) is the natural evolution of NPWT. This therapy combines the benefits of instillation with negative pressure. Advancements in the drape and the foam dressing has further advanced the utility of this therapy for use in orthopaedic trauma wounds. The technique for drape application plays an important role in maximizing the benefits of NPWTi-d. This article provides tips and guidance to ensure a proper dressing seal and other helpful instructions to maximize the benefits of NPWTi-d.
C1 [Duda, Marcus] Cone Hlth Med Grp, OrthoCare, 1211 Virginia St, Greensboro, NC 27401 USA.
   [Kim, Paul] Univ Texas Southwestern, Dept Plast Surg, Dallas, TX USA.
   [Kim, Paul] Univ Texas Southwestern, Dept Orthoped Surg, Dallas, TX USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas Southwestern
   Medical Center
RP Duda, M (通讯作者)，Cone Hlth Med Grp, OrthoCare, 1211 Virginia St, Greensboro, NC 27401 USA.
EM mduda@mac.com
OI DUDA, MARCUS/0000-0003-1179-1090; , Paul/0000-0002-6186-6890
CR Allen D, 2014, INT WOUND J, V11, P198, DOI 10.1111/j.1742-481X.2012.01073.x
   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
   Elhessy AH, 2021, INT WOUND J, V18, P902, DOI 10.1111/iwj.13592
   Fernández LG, 2020, WOUNDS, V32, P279
   Fernández LG, 2020, INT WOUND J, V17, P1829, DOI 10.1111/iwj.13471
   Fillingham YA, 2018, J ARTHROPLASTY, V33, P3090, DOI 10.1016/j.arth.2018.04.043
   Goss S G, 2012, J Am Coll Clin Wound Spec, V4, P74, DOI 10.1016/j.jccw.2014.02.001
   Karadsheh MJ, 2015, WOUNDS, V27, P244
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2018, WOUNDS, pS1
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Kim PJ, 2013, PLAST RECONSTR SURG, V132, P1569, DOI 10.1097/PRS.0b013e3182a80586
   Kim PJ, 2015, Wounds, V27, pS2
   Kimawi AA, 2017, WOUNDS, V29, P46
   Lessing C, 2011, WOUNDS, V23, P309
   McNichol L, 2013, J WOUND OSTOMY CONT, V40, P365, DOI 10.1097/WON.0b013e3182995516
   Rycerz AM, 2013, INT WOUND J, V10, P20, DOI 10.1111/iwj.12171
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   Willy C, 2017, UNFALLCHIRURG, V120, P549, DOI 10.1007/s00113-017-0375-5
NR 19
TC 1
Z9 1
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2022
VL 36
SU 4
BP S17
EP S21
DI 10.1097/BOT.0000000000002432
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 3Y2NF
UT WOS:000843564400005
PM 35994304
DA 2026-07-24
ER
PT J
AU Phillips, R
   Stannard, JP
   Crist, BD
AF Phillips, Rachel
   Stannard, James P.
   Crist, Brett D.
TI Incisional Negative Pressure Wound Therapy in Orthopaedic Trauma:
   Indications & Outcomes
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE wound management; incisional negative pressure wound therapy; negative
   pressure; incision management
ID FINANCIAL IMPACT; INFECTIONS
AB The treatment of surgical incisions has evolved. This article aims to discuss the indications and outcomes associated with the use of incisional negative pressure wound therapy (iNPWT) for the management of surgical incisions. Multiple factors play a role in the benefits seen with iNPWT. The primary indication for iNPWT is to help manage the closed surgical incision environment and remove fluid from the incision via application of continuous negative pressure at -125 mm Hg. Pertinent literature will be reviewed.
C1 [Phillips, Rachel; Stannard, James P.; Crist, Brett D.] Univ Missouri, Dept Orthopaed Surg, One Hosp Dr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia
RP Crist, BD (通讯作者)，Univ Missouri, Dept Orthopaed Surg, One Hosp Dr, Columbia, MO 65212 USA.
EM cristb@health.missouri.edu
RI Crist, Brett/AAC-7535-2019
CR Abbas SM, 2009, ANZ J SURG, V79, P247, DOI 10.1111/j.1445-2197.2009.04854.x
   Avsar P, 2021, WOUND MANAG PREV, V67, DOI 10.25270/wmp.2021.6.1019
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   Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
   Cagney D, 2020, WORLD J SURG, V44, P1526, DOI 10.1007/s00268-019-05335-x
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   Frazee R, 2018, J AM COLL SURGEONS, V226, P507, DOI 10.1016/j.jamcollsurg.2017.12.008
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   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
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   Shepard J, 2013, JAMA SURG, V148, P907, DOI 10.1001/jamasurg.2013.2246
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Suh H, 2016, ANN PLAS SURG, V76, P717, DOI 10.1097/SAP.0000000000000231
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NR 23
TC 0
Z9 1
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2022
VL 36
SU 4
BP S22
EP S25
DI 10.1097/BOT.0000000000002425
PG 4
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 3Y2NF
UT WOS:000843564400006
PM 35994305
DA 2026-07-24
ER
PT J
AU De Leon, JC
   Karia, RA
AF De Leon, Jorge C.
   Karia, Ravi A.
TI Incisional and Surrounding Periarticular Soft Tissue Management With
   Negative Pressure Therapy
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE incisional wound therapy; lower extremity periarticular fractures;
   negative pressure incisional wound therapy
ID WOUND THERAPY; INTERNAL-FIXATION; TIBIAL PLAFOND; OPEN REDUCTION;
   FRACTURES; COMPLICATIONS; PREVENTION
AB Periarticular injuries of the lower extremity are known for wound healing and infection complications. The role for incisional negative pressure wound therapy for lower extremity periarticular fractures has expanded over the last 10 years in hopes of minimizing complications. To date, there is no standardized published protocol of how negative pressure wound therapy is best used in lower extremity periarticular fractures. A review of strategies to decrease complications associated with the operative management of lower extremity periarticular fractures to include the use of incisional negative pressure wound therapy is presented.
C1 [De Leon, Jorge C.; Karia, Ravi A.] UT Hlth San Antonio, Dept Orthopaed, 4502 Med Dr, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas at San Antonio
RP Karia, RA (通讯作者)，UT Hlth San Antonio, Dept Orthopaed, 4502 Med Dr, San Antonio, TX 78229 USA.
EM karia@uthscsa.edu
CR Akiboye F, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0839-6
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NR 31
TC 0
Z9 0
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2022
VL 36
SU 4
BP S26
EP S30
DI 10.1097/BOT.0000000000002429
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 3Y2NF
UT WOS:000843564400007
PM 35994306
DA 2026-07-24
ER
PT J
AU Zelle, BA
   Kore, L
AF Zelle, Boris A.
   Kore, Lydia
TI How Can Negative Pressure Wound Therapy Pay for Itself?-Reducing
   Complications Is Important
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE tibia; fracture; costs; wound management
ID RISK-FACTORS; FRACTURE SURGERY; TIBIAL PLATEAU; INFECTION; REDUCTION;
   HIP; DRESSINGS; FIXATION
AB Introduction: Orthopaedic trauma demonstrates a relatively high rate of surgical site infections (SSI) as compared with other surgical specialties. SSIs provide significant clinical challenges and create significant health care costs. Incisional negative pressure wound therapy (iNPWT) has reduced the risk of SSI in orthopaedic surgery and other surgical specialties. Purpose: The purpose of this study is to investigate potential cost savings with the use of iNPWT (3M Prevena Therapy, 3M, St. Paul, MN) in high-risk orthopaedic trauma patients with closed OTA/AO 41C and 43C fractures. Methods: This is a retrospective cohort study performed at a single, level-1 trauma center using data from a lower extremity fracture registry. Using the results from the registry and baseline infection rates derived from the literature, a health economic model was developed to evaluate the potential cost savings. Results: A total of 79 patients included in the registry underwent open reduction and internal fixation of OTA/AO 41C and 43C fractures. A total of 10.1% developed a SSI. For those who received iNPWT, the rate of SSI was 7.4%. A health economic model suggests that the use of iNPWT may reduce the costs per patient by approximately $1381 to $4436 per patient. Conclusions: This health economic assessment and model suggests that judicious use of iNPWT may reduce health care costs in patients undergoing open reduction and internal fixation of OTA/AO 41C and 43C fractures.
C1 [Zelle, Boris A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Orthopaed Surg, San Antonio, TX 78229 USA.
   [Kore, Lydia] San Antonio Mil Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX USA.
C3 University of Texas System; University of Texas at San Antonio; Brooke
   Army Medical Center
RP Zelle, BA (通讯作者)，UT Hlth San Antonio, Dept Orthopaed Surg, 7703 Floyd Curl Dr,MC 7774, San Antonio, TX 78229 USA.
EM zelle@uthscsa.edu
FU 3M KCI Inc.
FX The study was partially funded by 3M KCI Inc.
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NR 26
TC 3
Z9 3
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2022
VL 36
SU 4
BP S31
EP S35
DI 10.1097/BOT.0000000000002427
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 3Y2NF
UT WOS:000843564400008
PM 35994307
DA 2026-07-24
ER
PT J
AU Gegouskov, V
   Manchev, G
   Goranovska, V
   Stoykov, D
AF Gegouskov, Vassil
   Manchev, Georgi
   Goranovska, Valya
   Stoykov, Dimitar
TI Negative Pressure Wound Therapy Becomes the Treatment of Choice of Deep
   Sternal Wound Infection
SO HEART SURGERY FORUM
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; MEDIASTINITIS; MORTALITY; RISK
AB Background: Sternal wound infection, especially deep sternal wound infection, is a serious complication after open heart surgery. It leads to a marked increase in hospital stay, financial expenses, and mortality. Treatment is primarily surgical and may be divided into conventional treatment methods and negative pressure wound therapy.
   Materials and methods: Between 2010 and 2021, 77 patients presenting back after cardiac surgery with deep sternal wound infection were treated surgically. Conventional treatment methods were utilized in 45 patients and included wound revision with primary closure, continuous wound irrigation, and open treatment with secondary closure. Negative-pressure wound therapy (NPWT) was applied in 32 patients. The two treatment arms were compared by two primary outcomes - rate of recurrent infection and hospital mortality. Predictors of mortality and infectious recurrence were identified using multivariate logistic regression.
   Results: Recurrent infection occurred in 18.2% of cases and mortality was 13% in the whole group. NPWT was more successful in preventing recurrent infection OR: 5.4 (95% CI: 1.1-27.5; P = 0.044) than conventional treatment and more than moderate left ventricular systolic dysfunction (EF<40%) predisposed to infectious recurrence - OR: 4.7 (95% CI: 1.05-22.1; P = 0.049). Recurrent infection itself was the strongest predictor of mortality in the multivariate model OR: 0.14 (95% CI: 0.03 - 0.58; P = 0.007).
   Conclusion: NPWT as an initial method of wound preconditioning followed by definitive wound closure effectively reduces the rate of infectious recurrence and patient mortality. It may become the modality of first choice when dealing with complicated incisional infections following heart surgery.
C1 [Gegouskov, Vassil; Manchev, Georgi; Goranovska, Valya] St Anna Univ Hosp, Dept Cardiac Surg, Sofia, Bulgaria.
   [Stoykov, Dimitar] Georgi Stranski Univ Hosp, Dept Surg, Pleven, Bulgaria.
   [Gegouskov, Vassil; Stoykov, Dimitar] Med Univ Pleven, Pleven, Bulgaria.
C3 Medical University Sofia; Medical University Pleven
RP Manchev, G (通讯作者)，St Anna Univ Hosp, Dept Cardiac Surg, Sofia, Bulgaria.
EM georgi.manchev@ymail.com
RI Manchev, Georgi/JVD-5199-2023
OI Manchev, Georgi/0000-0001-8643-0922
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NR 36
TC 3
Z9 3
U1 0
U2 2
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PY 2022
VL 25
IS 4
BP E601
EP E607
DI 10.1532/hsf.4791
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 3Z0IP
UT WOS:000844104900002
PM 36052909
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jiang, X
   Xu, Y
   Jiao, GQ
   Jing, ZH
   Bu, FY
   Zhang, J
   Wei, LY
   Rong, XS
   Li, MQ
AF Jiang, Xia
   Xu, Yong
   Jiao, Guoqing
   Jing, Zhaohui
   Bu, Fanyu
   Zhang, Jie
   Wei, Liuyan
   Rong, Xiaosong
   Li, Mingqiu
TI The combined application of antibiotic-loaded bone cement and vacuum
   sealing drainage for sternal reconstruction in the treatment of deep
   sternal wound infection
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Deep sternal wound infection; Antibiotic-loaded bone cement; Vacuum
   sealing drainage
ID ACUTE KIDNEY INJURY; CARDIAC-SURGERY; MEDIASTINITIS; VANCOMYCIN;
   PREVENTION; FLAPS
AB Background Deep sternal wound infection (DSWI) is a rare but serious complication after median sternotomy, and treatment success depends mainly on surgical experience. Traditional treatment methods for DSWI include complete debridement, vacuum sealing drainage wound therapy and sometimes transposition of muscle flap. This study aimed to evaluate the utility of antibiotic-loaded bone cement combined with vacuum sealing drainage on DSWI and explore the effect of this treatment on lung function. Methods Between January 2018 and December 2019, we treated 12 patients suffering a mediastinitis and open thorax using antibiotic-loaded bone cement combined with vacuum sealing drainage. Subsequently, the blood and local concentration of antibiotic were measured. The patient characteristics, pulmonary function, were retrospectively analyzed. Subjects were followed up for 12 months. Results There were no intraoperative deaths. All patients' healing wounds were first-stage healing without complications and reoperation, the mean hospital stay was 20.2 +/- 3.5 days. Local vancomycin concentrations largely exceeded the ones needed for their efficacy while little antibiotic was found in the blood. Pulmonary function testing was improved 2 weeks after the operation. No infection reoccurred in12-month follow-up. Conclusions The antibiotic-loaded bone cement combined with vacuum sealing drainage might be an effective method for the sternal reconstruction of deep sternal wound infection and it can improve the patient's lung function in a short time.
C1 [Jiang, Xia; Xu, Yong; Jiao, Guoqing; Jing, Zhaohui; Zhang, Jie; Wei, Liuyan; Rong, Xiaosong; Li, Mingqiu] Nanjing Med Univ, Wuxi Peoples Hosp, Wuxi Peoples Hosp, Dept Cardiovasc Surg, 299 Qingyang Rd, Wuxi 214203, Jiangsu, Peoples R China.
   [Bu, Fanyu] Soochow Univ, Wuxi Peoples Hosp 9, Dept Chron Wound, Wuxi 214062, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Jiangnan University; Soochow University -
   China
RP Rong, XS; Li, MQ (通讯作者)，Nanjing Med Univ, Wuxi Peoples Hosp, Wuxi Peoples Hosp, Dept Cardiovasc Surg, 299 Qingyang Rd, Wuxi 214203, Jiangsu, Peoples R China.
EM rxswx@163.com; LMQ.2109@163.com
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NR 32
TC 7
Z9 9
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD AUG 26
PY 2022
VL 17
IS 1
AR 209
DI 10.1186/s13019-022-01951-2
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 4A3FF
UT WOS:000844991000001
PM 36028875
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Prabakaran, PP
   Totty, JP
   Carradice, D
   Chetter, IC
   Smith, GE
AF Prabakaran, Praveena Priyadharsini
   Totty, Joshua P.
   Carradice, Dan
   Chetter, Ian C.
   Smith, George E.
TI The local physiological effects of a single-use topical negative
   pressure device in healthy volunteers: the PICO-1 study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE angiogenesis; healing; negative pressure; negative pressue wound
   therapy; PICO; perfusion; tissue oxygenation; tNPWT; wound; wound care;
   wound dressing; wound healing
ID CLOSED INCISION MANAGEMENT; WOUND THERAPY; BLOOD-FLOW
AB Objective: This study aimed to investigate the effects of a single-use negative pressure wound therapy (sNPWT) device on tissue perfusion, oxygenation and pressure in the intact skin of healthy volunteers.
   Method: Healthy volunteers wore a PICO sNPWT device (Smith+Nephew, UK) on their right medial calf for one week. Perfusion, tissue oxygenation and tissue pressure were recorded in superficial and deep tissues over a period of seven days. At the baseline visit, measurements were recorded before and after dressing application without activation. Macrovascular flow and transduced needle pressure measures were recorded at 0 minutes, 30 minutes and 60 minutes after device activation. Superficial tissue perfusion and both oxygenation measures were recorded continuously over the hour following activation. All outcome measures were repeated at 24 hours and again after seven days, both with the dressing and following dressing removal.
   Results: The device was associated with a measurable increase in perfusion of the limb in 12 healthy volunteers. Superficial tissue oxygenation adjacent to the dressing was reduced during wear, while deeper tissue demonstrated an increase in oxygenation levels. Superficial skin perfusion was observed to differ between skin overlying muscle and that overlying bone. Pressure in tissue underneath the dressing pad was increased throughout dressing wear and returned to baseline levels on dressing removal.
   Conclusion: sNPWT produced measurable changes in local physiology in healthy volunteers with intact skin, despite the absence of a wound. Effects may differ according to anatomical site and the composition of underlying tissues. Other factors that promote healing were not explored in this study.
C1 [Prabakaran, Praveena Priyadharsini; Totty, Joshua P.; Carradice, Dan; Chetter, Ian C.; Smith, George E.] Hull Royal Infirm, Acad Vasc Surg Unit, Kingston Upon Hull, N Humberside, England.
   [Totty, Joshua P.] Hull Univ Teaching Hosp, Dept Plast & Reconstruct Surg, Cottingham, England.
C3 University of Hull
RP Totty, JP (通讯作者)，Hull Royal Infirm, Acad Vasc Surg Unit, Kingston Upon Hull, N Humberside, England.; Totty, JP (通讯作者)，Hull Univ Teaching Hosp, Dept Plast & Reconstruct Surg, Cottingham, England.
EM joshua.totty@hyms.ac.uk
RI ; Carradice, Daniel/AFN-0257-2022; Totty, Joshua P/AAP-6655-2020
OI Smith, George/0000-0002-8085-0886; chetter, ian/0000-0002-2566-6859;
   Carradice, Daniel/0000-0002-7733-3925; Totty, Joshua
   P/0000-0002-0063-1414
FU Smith+Nephew [IIS 684]
FX This study was funded by Smith+Nephew investigator-initiated grant IIS
   684. The funder had no input into study design, conduct, analysis,
   manuscript preparation or dissemination. The authors have no conflicts
   of interest to declare.
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NR 30
TC 0
Z9 0
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2022
VL 31
IS 8
BP 624
EP 632
DI 10.12968/jowc.2022.31.8.624
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 4D0UE
UT WOS:000846858500002
PM 36001706
DA 2026-07-24
ER
PT J
AU Galstyan, GM
   Nalbandyan, SA
   Sabirov, KR
   Soboleva, OA
   Kovalenko, A
   Gorgidze, LA
   Zorenko, VY
AF Galstyan, G. M.
   Nalbandyan, S. A.
   Sabirov, K. R.
   Soboleva, O. A.
   Kovalenko, A., V
   Gorgidze, L. A.
   Zorenko, V. Y.
TI TREATMENT TACTICS FOR A PATIENT WITH ACQUIRED HEMOPHILIA: CONTINUOUS
   INFUSION OF RECOMBINANT ACTIVATED COAGULATION FACTOR VII AND THE
   INHIBITOR ERADICATION
SO GEMATOLOGIYA I TRANSFUZIOLOGIYA
LA Russian
DT Article
DE factor VIII; acquired hemophilia A; obstetric bleeding; rFVIIa; factor
   VIII inhibitor; vacuum-assisted laparostomy
ID CONGENITAL HEMOPHILIA; PREGNANCY; ANTIBODY; THERAPY
AB Introduction. Acquired hemophilia is a rare autoimmune disease caused by an inhibitor to clotting factor VIII (FVIII). It complicates the course of many diseases, in particular autoimmune diseases, and in women is often associated with pregnancy.
   Aim - to present a case of successful treatment of a patient with acquired hemophilia using long-term continuous infusion of rFVIIa and inhibitor eradication as a result of immunosuppressive therapy.
   Main findings. A clinical observation of severe hemorrhagic syndrome in a patient with acquired hemophilia associated with pregnancy is presented. Uterine bleeding in the patient after spontaneous delivery, refractory to standard hemorrhagic syndrome treatment, required multiple surgical interventions. Laboratory tests showed prolongation of APTT, CT in the INTEM rotational thromboelastometry test, a decrease in plasma FVIII activity and presence of inhibitor to FVIII. Vacuum-assisted closure was applied to treat infected laparotomy wound. Therapy for acquired hemophilia consisted of hemostatic therapy and the inhibitor eradication. Hemostatic therapy included a continuous infusion of rFVIIa at a rate of 30 mu g/kg/ h with a gradual decrease up to 9.6 mu g/kg/h, as well as its fractional administration before every surgery at a dosage of 80 mu g/kg. The effectiveness of the therapy was assessed by the dynamics of CT in the INTEM test and the shortening of the APTT. The inhibitor eradication was achieved by prednisolone therapy, combined immunosuppression with rituximab and azathioprine, followed by its replacement with cyclophosphamide. As a result, the hemorrhage was stopped, reference plasma activity of FVIII and eradication of the inhibitor were reached.
C1 [Galstyan, G. M.] Natl Med Res Ctr Hematol, Head Resuscitat & Intens Care Dept, Moscow 125167, Russia.
   [Galstyan, G. M.] Natl Med Res Ctr Obstet Gynecol & Perinatol, Dept Anesthesiol & Intens Care, Moscow 125167, Russia.
   [Nalbandyan, S. A.] Natl Med Res Ctr Hematol, Resuscitat & Intens Care Dept, Moscow 125167, Russia.
   [Sabirov, K. R.; Soboleva, O. A.; Kovalenko, A., V] Natl Med Res Ctr Hematol, Dept Surg, Moscow 125167, Russia.
   [Gorgidze, L. A.] Natl Med Res Ctr Hematol, Clin Pathol Express Lab, Resuscitat & Intens Care Unit, Moscow 125167, Russia.
   [Zorenko, V. Y.] Natl Med Res Ctr Hematol, Head Traumatol & Orthoped Dept, Moscow, Russia.
C3 Russian Academy of Medical Sciences; Research Center for Obstetrics,
   Gynecology & Perinatology
RP Galstyan, GM (通讯作者)，Natl Med Res Ctr Hematol, Head Resuscitat & Intens Care Dept, Moscow 125167, Russia.; Galstyan, GM (通讯作者)，Natl Med Res Ctr Obstet Gynecol & Perinatol, Dept Anesthesiol & Intens Care, Moscow 125167, Russia.
EM gengalst@gmail.com; siranushik1995@gmail.com; sabkirill@gmail.com;
   soboleva31@gmail.com; lana380@mail.ru; zorenko.vladimir@mail.ru
RI Galstyan, G.M/H-6398-2016; Lana, Gorgidze/P-8181-2014; /AAU-8827-2020
OI Galstyan, G.M/0000-0001-8818-8949; Nalbandyan,
   Siranush/0000-0002-3009-156X; Lana, Gorgidze/0000-0001-5235-2356;
   Kovalenko, Aleksey/0000-0002-6920-2490; Soboleva,
   Olga/0000-0001-9879-2664; 
CR [Anonymous], 2014, Nova Scotia operational guidelines for aquatic facilities, P1
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NR 30
TC 1
Z9 4
U1 0
U2 1
PU MINISTERSTVO ZDRAVOOKHRANENIYA
PI MOSCOW
PA NAUCHNIY PROEZD 6, B-246 MOSCOW, RUSSIA
SN 0234-5730
J9 GEMATOL TRANSFUZIOL
JI Gematol. Transfuziol.
PY 2022
VL 67
IS 2
BP 282
EP 294
DI 10.35754/0234-5730-2022-67-2-282-294
PG 13
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA 4D8HQ
UT WOS:000847380600010
OA gold
DA 2026-07-24
ER
PT J
AU Hays, TR
   Singh, G
   Saragossi, J
   Park, J
   Shekar, S
   Marquez, JE
   Dagum, AB
   Khan, SU
   Khan, FA
   Bui, DT
AF Hays, Thomas R.
   Singh, Gurtej
   Saragossi, Jamie
   Park, Jason
   Shekar, Shruthi
   Marquez, Jocellie E.
   Dagum, Alexander B.
   Khan, Sami U.
   Khan, Fazel A.
   Bui, Duc T.
TI Negative-Pressure Wound Therapy versus Standard Surgical Dressings after
   Malignant Tumor Resection: A Systematic Review and Meta-Analysis
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; ACRAL LENTIGINOUS MELANOMA; SITE INFECTIONS;
   PERINEAL WOUNDS; RECTAL-CANCER; LAPAROTOMY; EXCISION; PREVENTION;
   MANAGEMENT; CARE
AB Background: Negative-pressure wound therapy offers many advantages over standard surgical dressings in the treatment of open wounds, including accelerated wound healing, cost savings, and reduced complication rates. Although contraindicated by device manufacturers in malignancy-resected wounds because of hypothesized risk of tumor recurrence, negative-pressure wound therapy is still applied postoperatively because of limited clinical support. The authors performed a systematic review with meta-analysis to compare negative-pressure wound therapy outcomes with those of standard surgical dressings on open wounds, with their null hypothesis stating there would be no outcome differences.
   Methods: A systematic review of the literature on negative-pressure wound therapy and standard surgical dressings on malignancy-resected wounds was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using PubMed, Embase, CINAHL, and Cochrane Central databases. Meta-analysis compared group outcomes, including malignancy recurrence, wound complication, and surgical site infection rates, with a random effects model.
   Results: A total of 1634 studies were identified and 27 met eligibility criteria, including four randomized controlled trials, four prospective cohort studies, and 19 retrospective reviews. Eighty-one percent of articles (n = 22) recommended negative-pressure wound therapy in malignancy-resected wounds. Meta-analysis determined that the treatment yielded significantly lower overall surgical site infection (p = 0.004) and wound complication (p = 0.01) rates than standard surgical dressings; however, there were no statistically significant differences found for other outcomes between the two groups.
   Conclusions: This review demonstrates favorable outcomes of negative-pressure wound therapy over standard surgical dressings for malignancy-resected wounds without an increased risk of malignancy recurrence. However, because limited randomized controlled trials (detailing only incisional wounds for limited malignancies and anatomic regions) are available, additional high-power randomized controlled trials are recommended. (Plast. Reconstr. Surg. 150: 655e, 2022.)
C1 SUNY Stony Brook, Renaissance Sch Med, Stony Brook, NY 11794 USA.
   Stony Brook Univ Hosp, Dept Surg, Div Plast & Reconstruct Surg, Stony Brook, NY USA.
   Stony Brook Univ Hosp, Dept Surg, Div Orthoped Oncol, Stony Brook, NY USA.
   Stony Brook Univ Lib, Stony Brook, NY USA.
C3 State University of New York (SUNY) System; Stony Brook University;
   Stony Brook University Hospital; State University of New York (SUNY)
   System; Stony Brook University; Stony Brook University Hospital; State
   University of New York (SUNY) System; Stony Brook University; Stony
   Brook University Hospital
RP Bui, DT (通讯作者)，Hlth Sci Ctr T19-060, Stony Brook, NY 11794 USA.
EM duc.bui@stonybrookmedicine.edu
RI khan, Sami/ISS-4026-2023; Hays, Thomas/ABA-6640-2020
FU Office of Scientific Affairs at the Renaissance School of Medicine
FX This article was funded by the 2017 Targeted Research Opportunity
   Program Award received from the Office of Scientific Affairs at the
   Renaissance School of Medicine.
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NR 42
TC 5
Z9 5
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2022
VL 150
IS 3
BP 655E
EP 670E
DI 10.1097/PRS.0000000000009448
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 4E0RB
UT WOS:000847541300040
PM 35791292
DA 2026-07-24
ER
PT J
AU Katsumi, S
   Shinohara, A
   Kajiwara, T
   Saito, M
AF Katsumi, Shunsuke
   Shinohara, Akira
   Kajiwara, Takayoshi
   Saito, Mitsuru
TI Tension Pneumocephalus Associated with Negative Pressure Wound Therapy
   with Instillation and Dwell Time for Methicillin-resistant
   Staphylococcus aureus Infection After Spinal Deformity Surgery
SO EUROPEAN SPINE JOURNAL
LA English
DT Article
DE Pneumocephalus; NPWTi-d; Adult spinal deformity; SSI; MRSA; Spine
   surgery
ID COMPLICATION; TRENDS
AB Purpose Surgical site infection (SSI) is a serious complication after spine surgery. Recently, it has become possible to perform negative pressure wound therapy with instillation and dwell time (NPWTi-d) for postoperative infected wounds. We report the first rare case of symptomatic pneumoencephalopathy following NPWTi-d for methicillin-resistant Staphylococcus aureus (MRSA) infection after spinal deformity surgery. Methods Retrospective review of a patient's medical record and imaging. Results A 77-year-old female patient underwent posterior corrective fixation with no intraoperative complications. On the 10th postoperative day, SSI was diagnosed, and debridement was performed. Since MRSA was detected in the wound culture, and a prolonged inflammatory reaction was observed, NPWTi-d was started to preserve the instrumentation. Gradually, good granulation was observed, and the extensive soft tissue defect decreased. On the 29th day after the start of NPWTi-d, the patient experienced sudden headache and neck pain while standing, and head computed tomography led to the diagnosis of symptomatic pneumoencephalopathy. NPWTi-d was discontinued, and when surgery was performed to close the wound, dural injury was found, which was not present at the time of the initial surgery, and dural repair was performed. After 2 weeks of bed rest, the patient's pneumoencephalopathy improved. Three years have passed since the surgery, and no recurrence of cerebrospinal fluid leakage or infection has been observed. Conclusions Although NPWTi-d is a useful treatment for SSI, it is always necessary to pay attention to the development of pneumoencephalopathy and promptly diagnose and treat it because of the risk of life-threatening complications.
C1 [Katsumi, Shunsuke; Shinohara, Akira; Kajiwara, Takayoshi; Saito, Mitsuru] Jikei Univ, Sch Med, Dept Orthopaed Surg, Minato Ku, 3-19-18 Nishi Shinbashi, Tokyo 1058471, Japan.
C3 Jikei University
RP Katsumi, S (通讯作者)，Jikei Univ, Sch Med, Dept Orthopaed Surg, Minato Ku, 3-19-18 Nishi Shinbashi, Tokyo 1058471, Japan.
EM shnskktsm@gmail.com
OI Katsumi, Shunsuke/0000-0003-1682-2749; Saito,
   Mitsuru/0000-0003-1653-4309
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NR 17
TC 2
Z9 5
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0940-6719
EI 1432-0932
J9 EUR SPINE J
JI Eur. Spine J.
PD DEC
PY 2022
VL 31
IS 12
BP 3776
EP 3781
DI 10.1007/s00586-022-07367-9
EA SEP 2022
PG 6
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 8H0RE
UT WOS:000849447700001
PM 36056966
DA 2026-07-24
ER
PT J
AU Aslan-Horch, EC
   Horch, RE
   Arkudas, A
   Müller-Seubert, W
   Ludolph, I
AF Aslan-Horch, Emine Ceylan
   Horch, Raymund E.
   Arkudas, Andreas
   Mueller-Seubert, Wibke
   Ludolph, Ingo
TI Effects of Different Pressure Levels in Topical Negative Pressure
   Application-Analysis of Perfusion Parameters in a Clinical Skin Model
   Using Multimodal Imaging Techniques
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE negative pressure wound therapy; perfusion; pressure level; imaging;
   thermography; near infrared spectroscopy
ID VACUUM-ASSISTED CLOSURE; WOUND-THERAPY; BLOOD-FLOW; OXYGEN; GAUZE; WALL
AB The effects of topical negative pressure therapy (TNP) have been a subject of research for many years. In this study, we investigated new imaging devices to detect clinical changes that TNP causes on healthy tissue and identified differences in microcirculation created by different pressure levels. We used near-infrared spectroscopy (NIS), thermography, and a vein illuminator to measure the differences in oxygen saturation, tissue temperature, and vein pattern. A control group (-125 mmHg) and three comparison groups with only TNP dressing (Group 1), -25 mmHg (Group 2), and -175 mmHg (Group 3) were established. Thirty minutes of TNP on intact skin was followed by 30 min of resting. A total of 24 participants were measured by all imaging devices at predetermined time points. Oxygen saturation and skin temperature increased by 8.07% and 1.67 degrees C for the control group, 4.00% and 1.65 degrees C for Group 2, and 8.45% and 1.68 degrees C for Group 3. Group 1 showed a slight increase in oxygen saturation and a 2.7 degrees C increase in skin temperature. Over the 30 min following removal of TNP, oxygen saturation and temperature decreased gradually for all groups. The vein illuminator did not show significant differences in the venous pattern or flow. Our study showed that higher negative pressure values resulted in higher oxygen saturation and higher tissue temperature.
C1 [Ludolph, Ingo] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Hosp Erlangen, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
   Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Hosp Erlangen, Lab Tissue Engn & Regenerat Med, Krankenhausstr 12, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Ludolph, I (通讯作者)，Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Hosp Erlangen, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM ingo.ludolph@uk-erlangen.de
RI Horch, Raymund E/H-8128-2019; Arkudas, Andreas/AAQ-6745-2021
OI Horch, Raymund E/0000-0002-6561-2353; Arkudas,
   Andreas/0000-0002-2473-5816; Ludolph, Ingo/0000-0003-4806-7717;
   Aslan-Horch, Emine Ceylan/0000-0001-7931-0439
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NR 30
TC 7
Z9 8
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2022
VL 11
IS 17
AR 5133
DI 10.3390/jcm11175133
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4J2NP
UT WOS:000851105800001
PM 36079063
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yasti, AÇ
   Karaca, T
   Kendirci, M
   Akgün, AE
   Sahiner, IT
   Akin, M
AF Yasti, Ahmet Cinar
   Karaca, Turgut
   Kendirci, Murat
   Akgun, Ali Emre
   Sahiner, Ibrahim Tayfun
   Akin, Merve
TI Comparison of the Efficiency of Epidermal Growth Factor and Negative
   Pressure Wound Therapy in Diabetic Foot Patients
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE diabetic foot ulcers < Lower extremity wound; wound care; dressings;
   NPWT or TNP < Wound management; EGF; distalization of amputation
ID EGF; ENHANCE; ULCERS
AB Advanced modalities are used for wounds where conventional treatment is insufficient in diabetic foot patients. In this study, we investigated the effects of using Epidermal growth factor (EGF) and NPWTmodalities alone or in combination on the frequency and level of amputation. In the retrospective study, which included 286 patients in total, 76 patients were referred with the decision of amputation or amputation was planned during hospitalization. After the treatments, amputation and distalization of amputation were found 73.3% and 33.3% in the conventional treatment patients. While 86.4% amp and 18.2% amp distalization were found in negative pressure wound therapy (NPWT) only patients, this rate was 52.4% and 90.5% in EGF + NPWT patients, 50% and 83.3% in EGF only patients. While amp and distalization rates were found to be significantly better in those receiving only EGF or EGF + NPWT (P = .015, P = .017 respectively for amputation and P = .000 for distalization), no difference was found in those receiving EGF and EGF + NPWT. As a result of our study, although npwt contributed positively to the number and level of amputations compared to conventional treatment, a significant improvement was found in the number and level of amps when EGF was used alone or combined with NPWT. With this result, EGF was thought to be an important treatment modality that should be evaluated in diabetic foot ulcers (DFUs) without amputation decision.
C1 [Yasti, Ahmet Cinar] Hlth Sci Univ, Dept Gen Surg, Ankara, Turkey.
   [Kendirci, Murat; Sahiner, Ibrahim Tayfun] Hitit Univ, Dept Gen Surg, Corum, Turkey.
   [Akgun, Ali Emre; Akin, Merve] Ankara City Hosp, Gen Surg, Univ Mahallesi 1604,Cadde 9, TR-06800 Ankara, Cankaya, Turkey.
C3 University of Health Sciences Turkey; Hitit University; City Hospital
   Ankara; Presidency Turkey
RP Akin, M (通讯作者)，Ankara City Hosp, Gen Surg, Univ Mahallesi 1604,Cadde 9, TR-06800 Ankara, Cankaya, Turkey.
EM merveakin.2002@gmail.com
RI Akın, Merve/AAV-6282-2020; Kendirci, Murat/KIK-6978-2024; Sahiner,
   Ibrahim Tayfun/B-4864-2015; YASTI, AHMET CINAR/HPC-8757-2023
OI Akın, Merve/0000-0001-7224-4774; Akgün, Ali Emre/0000-0002-0389-4922;
   Sahiner, Ibrahim Tayfun/0000-0002-3921-7675; YASTI, AHMET
   CINAR/0000-0002-1281-3549
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NR 28
TC 3
Z9 3
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2023
VL 22
IS 1
BP 93
EP 102
DI 10.1177/15347346221123638
EA SEP 2022
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8O4OX
UT WOS:000851273600001
PM 36069057
DA 2026-07-24
ER
PT J
AU Sraj, S
   Henderson, JT
   Bramer, M
   Gelman, J
AF Sraj, Shafic
   Henderson, Joshua T.
   Bramer, Michelle
   Gelman, Jack
TI Principles of Fasciotomy Closure After Compartment Syndrome Release
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID DELAYED PRIMARY CLOSURE; TIBIAL PLATEAU FRACTURES; VACUUM-ASSISTED
   CLOSURE; WOUND CLOSURE; LEG; DERMATOTRACTION; INFECTION; DEVICE; TRAUMA
AB Acute compartment syndrome is a surgical emergency in the extremities resulting from increased compartmental pressure, requiring immediate fasciotomy to resolve muscular compromise. As the mainstay treatment, fasciotomies involve substantial skin incisions and are thus prone to complications such as skin necrosis, wound infection, and permanent disability. Multidisciplinary care instituted at the time of fasciotomy can facilitate timely closure and minimize the complication profile. Several approaches are available to enhance outcomes of fasciotomy wounds, and a comprehensive knowledge of these options affords the treating surgeon greater flexibility and confidence in optimal management. Common techniques include early primary closure, gradual approximation, skin grafting, and negative pressure therapy. There is currently no consensus on the best method of closure. The purpose of this study was to review fasciotomy wound management from the time of initial release to final closure. Highlights include preparation for closing these wounds; the various techniques for fasciotomy closure, including adjunct options; evaluation of timing and staging; and injury-specific features, such as fracture management, limited subcutaneous tissues, and hand fasciotomies. Combining the perspectives of orthopaedic and plastic surgery, this review evaluates the benefits of multiple closure methods and highlights the importance of planning closure at the time of release.
C1 [Sraj, Shafic; Bramer, Michelle] West Virginia Univ, Dept Orthopaed, Morgantown, WV 26506 USA.
   [Henderson, Joshua T.; Gelman, Jack] West Virginia Univ, Dept Surg, Div Plast Surg, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University
RP Sraj, S (通讯作者)，West Virginia Univ, Dept Orthopaed, Morgantown, WV 26506 USA.
RI Henderson, Joshua/ABD-2229-2021; Sraj, Shafic/CAH-2822-2022
OI Sraj, Shafic/0000-0003-3873-7369
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NR 44
TC 13
Z9 15
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD SEP 15
PY 2022
VL 30
IS 18
BP 879
EP 887
DI 10.5435/JAAOS-D-21-01046
PG 9
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 4M2MG
UT WOS:000853160300002
PM 36001887
DA 2026-07-24
ER
PT J
AU Li, JS
   Wang, Y
   Shao, XY
   Cheng, T
AF Li, Junsheng
   Wang, Yong
   Shao, Xiangyu
   Cheng, Tao
TI The salvage of mesh infection after hernia repair with the use of
   negative pressure wound therapy (NPWT), a systematic review
SO ANZ JOURNAL OF SURGERY
LA English
DT Review
DE hernia; mesh infection; mesh salvage; negative pressure wound therapy;
   NPWT
ID VACUUM-ASSISTED CLOSURE; INCISIONAL HERNIA; ABDOMINAL WOUNDS;
   MANAGEMENT; DEHISCENCE; SURGERY
AB Background Mesh infection is the most feared postoperative complication after abdominal wall hernia repair, often needs mesh removal. Negative pressure wound therapy (NPWT) has been used in these situations with diverse results. The aim of this study was to investigate the efficacy of the NPWT in the treatment of mesh infection, the primary outcome was the mesh salvage rates of different type of meshes and mesh positions. Methods Major databases were searched using the keywords negative pressure wound therapy, VSD, vacuum assisted, hernia, mesh infection, including various combinations of the terms. All relevant articles and reference lists in these original studies were also obtained from the above databases. Results Ten articles containing 265 patients on the treatment of mesh infection after hernia repair with the use of NPWT method were included. The general infected mesh salvage rate with NPWT was 76.2%. The highest mesh salvage rate was achieved in polypropylene mesh (93.5%), followed by Proceed mesh (83.3%), and the mesh salvage rate was lower in polyester mesh (PCO) (0%) and the ePTFE mesh (14/3%). The salvage rate was higher when mesh placed in the onlay position (82.6%) or retromuscular/sublay position (98.5%), but lower in the IPOM position (55.6%). Conclusion The treatment of mesh infection after hernia repair should be individualized according to the mesh type, mesh position and the severity of infection. Infected mesh with favourable mesh materials (large pore and monofilament polypropylene) and favourable positions (onlay or sublay/retromuscular) can be salvaged with the use of NPWT based conservative method.
C1 [Li, Junsheng; Shao, Xiangyu; Cheng, Tao] Southeast Univ, Affiliated Zhongda Hosp, Dept Gen Surg, Nanjing 210009, Peoples R China.
   [Wang, Yong] Sichuan Univ, West China Hosp, Dept Gastrointestinal Surg, Chengdu, Peoples R China.
C3 Southeast University - China; Sichuan University
RP Li, JS (通讯作者)，Southeast Univ, Affiliated Zhongda Hosp, Dept Gen Surg, Nanjing 210009, Peoples R China.
EM lijunshenghd@126.com
RI Li, Junsheng/E-4990-2013
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NR 37
TC 9
Z9 9
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD OCT
PY 2022
VL 92
IS 10
BP 2448
EP 2456
DI 10.1111/ans.18040
EA SEP 2022
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5E8PQ
UT WOS:000853826400001
PM 36106686
DA 2026-07-24
ER
PT J
AU Ching, AH
   Hong, QE
   Chew, KY
   Tan, BK
AF Ching, Ann-Hui
   Hong, Qi-En
   Chew, Khong-Yik
   Tan, Bien-Keem
TI Maximizing Micrograft Take in Extensive Back Burns
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
AB Extensive burns involving the back pose unique challenges. Offloading in the prone position is not possible with concomitant deep facial and neck burns. We describe our experience in maximizing graft take in a patient who had extensive back burns with concomitant anterior body burns. The two main goals in graft fixation for extensive back wounds are mechanical stabilization of micrografts to reduce shearing and prevention of water logging from exudates or bleeding to optimize contact with wound bed. Guided by the stages of wound healing, graft take, and burn care, we describe three stages of postoperative negative pressure wound therapy (NPWT) in a patient with 54% TBSA burns treated with micrografting. After complete excision of the deep dermal burns of the entire back, the wounds were covered with micrograft-allograft composites. In phase I, days 1 to 3, conventional topical negative pressure dressing with a thin sponge was applied and a leak-proof seal was achieved with gel sealant and high tack adhesive drapes. In phase II, days 4 to 5, foam dressings with topical negative pressure were applied, but with a less stringent seal, supported by wall suction. In phase III, the selective removal of allografts was initiated to facilitate expansion of micrografts. Negative pressure was continued for another 2 weeks at the most dependent site to prevent wound maceration from exudates. Micrograft take was optimized with the patient in the supine/semirecumbent position. The back wounds healed completely between 60 and 70 days without repeat micrografting. Since prone positioning was not possible in this patient, clearance of exudates and maintenance of micrograft contact with the wound bed using this technique proved successful.
C1 [Ching, Ann-Hui; Hong, Qi-En; Chew, Khong-Yik; Tan, Bien-Keem] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
C3 Singapore General Hospital
RP Tan, BK (通讯作者)，Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
EM bienkeem@gmail.com
OI Ching, Ann Hui/0000-0001-5074-7821
FU SingHealth Medical Student Talent Development Award
FX SingHealth Medical Student Talent Development Award (SMSTDA) 2021 2nd
   Cycle.
CR [Anonymous], SKIN
   Chong SJ, 2017, BURNS, V43, P983, DOI 10.1016/j.burns.2017.01.030
   Chong Si Jack, 2010, Burns, V36, pe127, DOI 10.1016/j.burns.2010.05.007
   Grunzweig KA, 2019, J PLAST RECONSTR AES, V72, P871, DOI 10.1016/j.bjps.2018.12.036
   Jeschke MG, 2020, NAT REV DIS PRIMERS, V6, DOI 10.1038/s41572-020-0145-5
   Kwee MM, 2015, INT SURG, V100, P292, DOI 10.9738/INTSURG-D-13-00256.1
   Low OW, 2013, BURNS, V39, P1420, DOI 10.1016/j.burns.2013.03.010
   Lund CC., 1944, SURG GYNECOLOGY OBST, V79, P352
   Yin YC, 2018, INT J SURG, V50, P43, DOI 10.1016/j.ijsu.2017.12.020
NR 9
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD NOV 2
PY 2022
VL 43
IS 6
BP 1449
EP 1452
DI 10.1093/jbcr/irac130
EA SEP 2022
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 5W2SX
UT WOS:000853926800001
PM 36053550
DA 2026-07-24
ER
PT J
AU Barker, CS
   Santa Lucia, G
   Brunette, G
   Lee, LW
AF Barker, Catherine S.
   Santa Lucia, Gabriella
   Brunette, Glenda
   Lee, Lara Wine
TI Treatment of Pediatric Pyoderma Gangrenosum With Modified Negative
   Pressure Wound Therapy and Intralesional Corticosteroids A Case Report
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Inflammatory bowel disease; Intralesional corticosteroids; Negative
   pressure wound therapy; Pediatric; Pyoderma gangrenosum
ID MANAGEMENT; SKIN
AB BACKGROUND: Pyoderma gangrenosum (PG) is a rare ulcerative skin disease; its etiology is unknown, though it is often associated with autoimmune diseases. Pyoderma gangrenosum results in significant morbidity and exquisite pain that affects health-related quality of life. Wound healing is delayed, and patients often experience relapse. Pyoderma gangrenosum is susceptible to pathergy and deterioration with surgical intervention or other trauma; therefore, treatment includes atraumatic wound care, infection management, and local or systemic immunosuppression. CASE: We describe the use of modified negative pressure wound therapy (NPWT) with intralesional and topical steroids for the treatment of PG in a 15-year-old female patient with ulcerative colitis and a staged J-pouch ileoanal reconstruction. The patient and her family refused all systemic therapy due to prior steroid-associated weight gain. She was unable to tolerate conscious dressing changes, further complicating the treatment plan. Procedural interventions such as NPWT have been used previously for PG; however, they can cause wound pathergy and subsequent wound deterioration. Modified NPWT in conjunction with topical and intralesional steroids induced wound healing without producing pathergy. CONCLUSION: Timely recognition of PG is crucial to appropriate delivery of care. Modified NPWT and localized corticosteroid treatment were key to promoting wound healing in this case of pediatric PG.
C1 [Barker, Catherine S.; Santa Lucia, Gabriella; Lee, Lara Wine] Med Univ South Carolina, Dept Dermatol & Dermatol Surg, 135 Rutledge Ave,MSC 578, Charleston, SC 29425 USA.
   [Brunette, Glenda] Med Univ South Carolina, Dept Specialty Nursing, Charleston, SC 29425 USA.
C3 Medical University of South Carolina; Medical University of South
   Carolina
RP Barker, CS (通讯作者)，Med Univ South Carolina, Dept Dermatol & Dermatol Surg, 135 Rutledge Ave,MSC 578, Charleston, SC 29425 USA.
EM cshirer@ymail.com
CR Afifi L, 2018, J AM ACAD DERMATOL, V78, P1195, DOI 10.1016/j.jaad.2017.12.049
   Ahronowitz I, 2012, AM J CLIN DERMATOL, V13, P191, DOI 10.2165/11595240-000000000-00000
   Alonso-León T, 2020, INT WOUND J, V17, P1774, DOI 10.1111/iwj.13466
   Bingoel AS, 2021, WOUND REPAIR REGEN, V29, P478, DOI 10.1111/wrr.12918
   Burlando M, 2021, J WOUND OSTOMY CONT, V48, P460, DOI 10.1097/WON.0000000000000798
   Dragasevic S, 2020, METAB SYNDR RELAT D, V18, P31, DOI 10.1089/met.2019.0090
   Eisendle K, 2020, ADV WOUND CARE, V9, P405, DOI 10.1089/wound.2020.1160
   Hirai K, 2022, PRS-GLOB OPEN, V10, DOI 10.1097/GOX.0000000000004111
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Jin SY, 2021, INT J LOW EXTR WOUND, V20, P158, DOI 10.1177/1534734620940459
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   Mathes M., 2021, UPTODATE
   Pichler M, 2016, J AM ACAD DERMATOL, V74, P760, DOI 10.1016/j.jaad.2015.09.009
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NR 16
TC 0
Z9 0
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2022
VL 49
IS 5
BP 488
EP 491
DI 10.1097/WON.0000000000000904
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 4N3SW
UT WOS:000853939700015
PM 36108234
DA 2026-07-24
ER
PT J
AU Yin, XL
   Hu, L
   Li, T
   Zou, Y
   Li, HL
AF Yin, Xiao-Ling
   Hu, Ling
   Li, Ting
   Zou, Yi
   Li, Hong-lin
TI A meta-analysis on the efficacy of vacuum sealing drainage combined with
   autologous platelet-rich plasma in the treatment of Grade 2 and Grade 3
   diabetic foot ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE diabetic foot; meta-analysis; platelet-rich plasma; ulcer; vacuum
   sealing drainage
AB This meta-analysis aims to systemically evaluate the efficacy of vacuum sealing drainage (VSD) combined with autologous platelet-rich plasma (PRP) in the treatment of diabetic foot ulcers (DFU). The China HowNet, China Biomedical Literature, VIP periodical resource integration service platform, Wanfang, Embase, Cochrane Central, and PubMed databases were retrieved using the computer. The retrieval period was up to July 2021. Randomised controlled trials on VSD combined with PRP in the treatment of DFU were collected. Those trials that met the inclusion criteria were included for meta-analysis using RevMan 5.3 software. A total of 13 articles were included. In the trial group, 477 patients with DFU were treated with VSD combined with PRP, while in the control group, 482 patients with DFU were treated with conventional dressings and/or VSD. The meta-analysis showed that, compared with the control group, VSD combined with PRP has significant advantages in shortening healing time (standardised mean difference [SMD] = -0.87, 95% confidence interval [CI]: -1.07 to -0.67, P < .00001), improving ulcer healing rates (odds ratio 4.01, 95% CI: 2.95 similar to 5.46, P < .00001), and reducing hospital stays (mean difference = -15.29, 95% CI: -16.05 to -14.54, P < .00001), but the differences in dressing change times (SMD = -1.27, 95% CI: -2.71 to 0.17, P .08) and hospitalisation expenses (SMD = -0.16, 95% CI: -13.40 to 13.07, P = .98) were not statistically significant. VSD combined with autologous PRP has good curative efficacy in the treatment of DFU and is a better treatment option. However, this treatment is limited in patients with platelet dysfunction, thrombocytopenia, leukaemia, and poor general condition.
C1 [Yin, Xiao-Ling; Hu, Ling; Li, Ting; Zou, Yi] Nanchang Univ, Dept Endocrinol, Hosp Nanchang 1, Affiliated Hosp 3, 128 Xiangshan North Rd, Nanchang 330008, Jiangxi, Peoples R China.
   [Li, Hong-lin] Med Coll Georgia, Dept Biochem, Augusta, GA 30912 USA.
C3 Nanchang University; University System of Georgia; Augusta University
RP Hu, L (通讯作者)，Nanchang Univ, Dept Endocrinol, Hosp Nanchang 1, Affiliated Hosp 3, 128 Xiangshan North Rd, Nanchang 330008, Jiangxi, Peoples R China.
EM drhu_hl1172@163.com
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   Zhou LH., 2017, Chin J Front Med Sci, V9, P131
NR 35
TC 18
Z9 19
U1 1
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2023
VL 20
IS 4
BP 1033
EP 1041
DI 10.1111/iwj.13956
EA SEP 2022
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA A7RQ8
UT WOS:000854080200001
PM 36111514
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kalaiselvan, R
   Slade, DAJ
   Soop, M
   Burnett, H
   Lees, NP
   Anderson, ID
   Lal, S
   Carlson, GL
AF Kalaiselvan, Ramya
   Slade, Dominic A. J.
   Soop, Mattias
   Burnett, Hugh
   Lees, Nicholas P.
   Anderson, Iain D.
   Lal, Simon
   Carlson, Gordon L.
TI Impact of negative pressure wound therapy on enteroatmospheric
   fistulation in the septic open abdomen
SO COLORECTAL DISEASE
LA English
DT Article; Proceedings Paper
CT International Surgical Congress of the
   Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI)
CY MAY 09-11, 2018
CL Liverpool, ENGLAND
SP Assoc Surg Great Britain & Ireland
DE abdominal sepsis; fistula; intestinal failure
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMINAL WOUNDS; TEMPORARY CLOSURE; OPEN
   MANAGEMENT
AB Aim: The effect of negative pressure wound therapy (NPWT) on the pathogenesis and outcome of enteroatmospheric fistulation (EAF) in the septic open abdomen (OA) is unclear. This study compares the development and outcome of EAF following NPWT with that occurring in the absence of NPWT.
   Methods: Consecutive patients admitted with EAF following abdominal sepsis at a National Reference Centre for intestinal failure between 01 January 2005 and 31 December 2015 were included in this study. Patients were divided into two groups based on those that had been treated with NPWT and those that had not (non-NPWT) and characteristics of their fistulas compared. Clinical outcomes concerning nutritional autonomy at 4 years and time to fistula development, size of abdominal wall defect and complete fistula closure were compared between groups.
   Results: A total of 160 patients were admitted with EAF following a septic abdomen (31-NPWT and 129-non-NPWT). Median (range) time taken to fistulation after OA was longer with NPWT (18 [5-113] vs. 8 [2-60] days, p = 0.004); these patients developed a greater number of fistulas (3 [2-21] vs. 2 [1-10], p = 0.01), involving a greater length of small bowel (42.5 [15-100] cm vs. 30 [3.5-170] cm, p = 0.04) than those who did not receive NPWT. Following reconstructive surgery, nutritional autonomy was similar in both groups (77% vs. 72%) and a comparable number of patients were also fistula-free (100% vs. 97%).
   Conclusions: Negative pressure wound therapy appears to be associated with more complex and delayed intestinal fistulation, involving a greater length of small intestine in the septic OA. This did not, however, appear to adversely affect the overall outcome of intestinal and abdominal wall reconstruction in this study.
C1 [Kalaiselvan, Ramya; Slade, Dominic A. J.; Soop, Mattias; Lees, Nicholas P.; Anderson, Iain D.; Lal, Simon; Carlson, Gordon L.] Salford Royal NHS Fdn Trust, Dept Surg, Natl Reference Ctr Intestinal Failure, Eccles Old Rd, Manchester M6 8HD, Lancs, England.
   [Burnett, Hugh] Christie NHS Fdn Trust, Dept Radiol, Manchester, Lancs, England.
C3 Salford Royal NHS Foundation Trust; Christie NHS Foundation Trust
RP Carlson, GL (通讯作者)，Salford Royal NHS Fdn Trust, Dept Surg, Natl Reference Ctr Intestinal Failure, Eccles Old Rd, Manchester M6 8HD, Lancs, England.
EM gordon.carlson@nca.nhs.uk
RI Soop, Mattias/AAQ-3417-2021; Slade, Dominic/AAE-8585-2022
OI Lal, Simon/0009-0005-9742-4946; Slade, Dominic/0000-0002-6032-8580
CR Adkins AL, 2004, AM SURGEON, V70, P137
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NR 24
TC 1
Z9 1
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JAN
PY 2023
VL 25
IS 1
BP 111
EP 117
DI 10.1111/codi.16318
EA SEP 2022
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology; Surgery
GA GZ0A1
UT WOS:000855354200001
PM 36031878
DA 2026-07-24
ER
PT J
AU Kim, YN
   Chang, YS
   Cho, KR
   Kim, BY
AF Kim, Young Nam
   Chang, Young-Soo
   Cho, Kyoung Rai
   Kim, Bo Young
TI A Case of Massive Subcutaneous Emphysema and Pneumomediastinum Due to
   Dehiscence of Stoma After Emergent Tracheostomy
SO ENT-EAR NOSE & THROAT JOURNAL
LA English
DT Article
DE complication; emphysema; pneumomediastinum; tracheostomy
AB Tracheostomy is commonly performed on patients who require long-term ventilator support. As with all other airway managements, tracheostomy comes with risks: tracheal scarring, tracheal rupture, pneumothorax, and tracheoesophageal fistula. Although rare, free air leakage into the surrounding tissues of the tracheostomy site and consequent pneumomediastinum can also occur due to various reasons, such as tracheal rupture and mispositioning of the tracheal tube. Such conditions may require treatments including high flow oxygen, ventilator management, and occasionally surgical intervention. In our case of a 61-year-old female, emergent tracheostomy was performed and subsequent complications of massive pneumomediastinum and subcutaneous emphysema were treated with negative pressure wound therapy. The follow-up radiograph after negative pressure wound therapy showed resolution of pneumomediastinum and subcutaneous emphysema, and there were no additional complications. Negative pressure wound therapy is an effective treatment option for massive pneumomediastinum and subcutaneous emphysema after tracheostomy.
C1 [Kim, Young Nam; Chang, Young-Soo; Cho, Kyoung Rai; Kim, Bo Young] Inje Univ, Dept Otorhinolaryngol Head & Neck Surg, Sanggye Paik Hosp, 1342 Dongil Ro, Gimhae 01757, South Korea.
C3 Inje University
RP Kim, BY (通讯作者)，Inje Univ, Dept Otorhinolaryngol Head & Neck Surg, Sanggye Paik Hosp, 1342 Dongil Ro, Gimhae 01757, South Korea.
EM by0131@gmail.com
OI Kim, Bo Young/0000-0001-6240-1465
CR Ali M., 2018, BMJ CASE REP
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NR 10
TC 4
Z9 4
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-5613
EI 1942-7522
J9 ENT-EAR NOSE THROAT
JI ENT-Ear Nose Throat J.
PD MAY
PY 2023
VL 102
IS 5
BP 307
EP 311
DI 10.1177/01455613221129435
EA SEP 2022
PG 5
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA H3ID1
UT WOS:000855514800001
PM 36124380
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Patton, D
   Avsar, P
   Wilson, P
   Mairghani, M
   O'Connor, T
   Nugent, L
   Moore, Z
AF Patton, Declan
   Avsar, Pinar
   Wilson, Pauline
   Mairghani, Maisoon
   O'Connor, Tom
   Nugent, Linda
   Moore, Zena
TI Treatment of diabetic foot ulcers: review of the literature with regard
   to the TIME clinical decision support tool
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE debridement; diabetic foot ulcer; negative pressure wound therapy;
   ischaemia; wound; wound care; wound dressing; wound healing
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; BED PREPARATION;
   MANAGEMENT; DRESSINGS; METAANALYSIS; DEBRIDEMENT; HONEY; PAIN; SKIN
AB Objective: The aim of this clinically orientated paper is to offer an overview of diabetic foot ulcer (DFU) dressings generally, and more specifically, their use in the treatment of DFUs.
   Method: The TIME clinical decision support tool (CDST) has been used as a clinical tool that can help clinicians bring together the different aspects of dressings for DFU treatment into a holistic approach to patient care.
   Results: DFUs are often difficult to heal, are painful and impact negatively on the individual's quality of life. Most DFU dressings are designed to support the healing of hard-to-heal wounds and represent one part of the management of DFUs. Apart from providing a moist environment, absorbing increased exudate, enhancing granulation and assisting in autolysis, the dressings need to be cost-effective. Wound dressing selection is based on clinical knowledge that ensures the dressing is most appropriate for the individual and the wound, taking into account the comorbidities that the individual may have.
   Conclusion: This paper has highlighted how the use of the TIME CDST model can enhance clinical care and is a further tool clinicians should consider when developing and executing DFU treatment plans. Future research needs to focus on large multicentre studies using robust methodologies, given the current gaps in the evidence, to determine the effectiveness of dressing products for DFUs.
C1 [Patton, Declan; O'Connor, Tom; Nugent, Linda; Moore, Zena] Univ Med & Hlth Sci, Sch Nursing & Midwifery, Royal Coll Surg Ireland RCSI, Dublin, Ireland.
   [Patton, Declan; Avsar, Pinar; Wilson, Pauline; O'Connor, Tom; Moore, Zena] RCSI Univ Med & Hlth Sci, Skin Wounds & Trauma Res Ctr, Sch Nursing & Midwifery, Dublin, Ireland.
   [Patton, Declan; O'Connor, Tom; Nugent, Linda; Moore, Zena] Fakeeh Coll Hlth Sci, Jeddah, Saudi Arabia.
   [Patton, Declan] Univ Wollongong, Fac Sci Med & Hlth, Wollongong, NSW, Australia.
   [Patton, Declan; O'Connor, Tom] Griffith Univ, Nathan, Qld, Australia.
   [Mairghani, Maisoon] RCSI Univ Med & Hlth Sci, Publ Hlth & Epidemiol, Dublin, Ireland.
   [O'Connor, Tom; Moore, Zena] Lida Inst, Shanghai, Peoples R China.
   [Moore, Zena] Monash Univ, Fac Med Nursing & Hlth Sci, Melbourne, Vic, Australia.
   [Moore, Zena] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth, Ghent, Belgium.
   [Moore, Zena] Univ Wales Coll Cardiff, Cardiff, Wales.
C3 Royal College of Surgeons in Ireland - RCSI; Royal College of Surgeons
   in Ireland - RCSI; Fakeeh College for Medical Sciences; University of
   Wollongong; Griffith University; Royal College of Surgeons in Ireland -
   RCSI; Monash University; Ghent University; Cardiff University
RP Avsar, P (通讯作者)，RCSI Univ Med & Hlth Sci, Skin Wounds & Trauma Res Ctr, Sch Nursing & Midwifery, Dublin, Ireland.
EM pinaraysar@rcsi.com
RI Nugent, Linda Elizabeth/P-1922-2015
OI Nugent, Linda Elizabeth/0000-0001-7480-8545; AVSAR,
   PINAR/0000-0002-7637-1700; Patton, Declan/0000-0003-1018-2605
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NR 94
TC 5
Z9 6
U1 1
U2 12
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2022
VL 31
IS 9
BP 771
EP 779
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 4R2DS
UT WOS:000856579500006
PM 36113541
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Gonzalez, GA
   Castagno, C
   Carter, J
   Chellappan, B
   Taupin, P
AF Gonzalez, Gilberto A.
   Castagno, Christopher
   Carter, Jordan
   Chellappan, Brinda
   Taupin, Philippe
TI Negative pressure wound therapy on complex extremity wounds requiring
   coverage with a meshed bilayer wound matrix: a retrospective analysis
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE acellular dermal matrix; diabetes; exposed structure; infection; Integra
   Meshed Bilayer Wound Matrix; postoperative complications; retrospective
   review; wound; wound care; wound dressing; wound healing
ID DERMAL REGENERATION TEMPLATE; SCALP RECONSTRUCTION; SKIN SUBSTITUTES;
   ARTIFICIAL SKIN; TISSUE; INTEGRA; PATIENT
AB Objective: The treatment of complex extremity wounds is technically challenging. In this 5-year retrospective review, we compared the use of Integra Meshed Bilayer Wound Matrix (IMBWM; Integra LifeSciences, US) followed by a split-thickness skin graft (STSG) combined with negative pressure wound therapy (NPWT) versus IMBWM followed by STSG alone for the management of these wounds.
   Method: Data from patients undergoing management using IMBWM for a complex extremity wound coverage were collected.
   Results: Among the 109 patients studied, the wounds of 62 patients were managed using IMBWM and NPWT, and 47 were managed using IMBWM alone. The most common aetiology of these injuries was trauma. Wound size and location were similar for each group, ranging in size from 2-30cm(2) and being primarily on the forearm, followed by the leg and arm. There was a significantly greater take of the IMBWM+STSG with NPWT (96.8%) compared to without NPWT (85.1%, p=0.03). There were significantly fewer reapplications of the dermal matrix required in the NPWT group (3.2%) versus the non-NPWT group (14.9%, p=0.03). There were significantly fewer postoperative complications, prior to STSG, in the NPWT group (3.2%) versus the non-NPWT group (14.9%, p=0.03).
   Conclusion: The combination of IMBWM with NPWT leads to a higher success rate, and can reduce the number of dermal matrix reapplications and postoperative complications, in the setting of complex extremity wounds. The use of IMBWM in combination with NPWT has the potential to improve both surgical procedures and patient outcomes in this setting.
C1 [Gonzalez, Gilberto A.] Texas Tech Univ Hlth Sci Ctr, Orthoped Surg, El Paso, TX 79905 USA.
   [Castagno, Christopher; Carter, Jordan; Chellappan, Brinda] Texas Tech Univ Hlth Sci Ctr, El Paso, TX USA.
   [Taupin, Philippe] Integra LifeSci, Med Affairs, Princeton, NJ USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center El Paso; Texas Tech University System; Texas Tech University
   Health Sciences Center El Paso
RP Gonzalez, GA (通讯作者)，Texas Tech Univ Hlth Sci Ctr, Orthoped Surg, El Paso, TX 79905 USA.
EM gilberto.a.gonzalez@ttuhsc.edu
OI Carter, Jordan/0000-0001-8320-1251
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NR 38
TC 6
Z9 6
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2022
VL 31
IS 9
SU S
BP S8
EP S15
DI 10.12968/jowc.2022.31.Sup9.S8
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 4R2KF
UT WOS:000856597000003
PM 36113853
DA 2026-07-24
ER
PT J
AU Park, JH
   Park, JU
AF Park, Jun Ho
   Park, Ji-Ung
TI Flap monitoring with incisional negative pressure wound therapy (NPWT)
   in diabetic foot patients
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; VENOUS CONGESTION; RECONSTRUCTION; MANAGEMENT;
   SALVAGE; DISEASE; CARE
AB Various types of flaps are considered as reconstructive options for patients with diabetic foot ulcer. However, flap reconstruction for diabetic foot ulcer treatment is particularly challenging because of the relatively limited collateral perfusion in the distal lower extremity. This study evaluated the efficacy and safety of a novel postoperative monitoring procedure implemented in conjunction with negative pressure wound therapy immediately after flap operations for treating diabetic foot. A retrospective analysis was performed on diabetic foot patients who underwent free flaps and perforator flaps from March 2019 through August 2021. The surgical outcomes of interest were the rates of survival and complications. On the third postoperative day, patients underwent computed tomography angiography to check for pedicle compression or fluid collection in the sub-flap plane. Monitoring time, as well as comparisons between NPWT and conventional methods, were analyzed. Statistical analysis was performed between the two groups. This study included 26 patients. Among patients, the negative pressure wound Therapy treated group included 14 flaps and the conventional monitoring group included 12 flaps. There was no significant intergroup difference in flap survival rate (p = 0.83). In addition, there was no significant intergroup difference in the diameters of perforators or anastomosed vessels before and after negative pressure wound therapy (p = 0.97). Compared with conventional monitoring, flap monitoring with incisional negative pressure wound therapy was associated with a significantly lower mean monitoring time per flap up to postoperative day 5. Although conventional monitoring is widely recommended, especially for diabetic foot ulcer management, the novel incisional negative pressure wound therapy investigated in this study enabled effortless serial flap monitoring without increasing complication risks. The novel flap monitoring technique is efficient and safe for diabetic foot patients and is a promising candidate for future recognition as the gold standard for flap monitoring.
C1 [Park, Jun Ho; Park, Ji-Ung] Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Plast & Reconstruct Surg, Coll Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital
RP Park, JU (通讯作者)，Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Plast & Reconstruct Surg, Coll Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea.
EM alfbskan@gmail.com
FU Seoul National University Hospital Research Fund [0420214050]
FX This work was supported by a clinical research grant-in-aid from the
   Seoul National University Hospital Research Fund (no.0420214050).
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   Chen KT, 2007, PLAST RECONSTR SURG, V120, P187, DOI 10.1097/01.prs.0000264077.07779.50
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   Ignatiadis IA, 2011, DIABET FOOT ANKLE, V2, DOI 10.3402/dfa.v2i0.7483
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   Suh HSP, 2016, PLAST RECONSTR SURG, V138, P1333, DOI 10.1097/PRS.0000000000002765
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NR 41
TC 8
Z9 11
U1 2
U2 14
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 20
PY 2022
VL 12
IS 1
AR 15684
DI 10.1038/s41598-022-20088-9
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 4S1CD
UT WOS:000857187000048
PM 36127377
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Farré, R
   Rodríguez-Lázaro, MA
   Gonzalez-Martin, J
   Castro, P
   Hospital, T
   Compta, Y
   Solana, G
   Gozal, D
   Otero, J
AF Farre, Ramon
   Rodriguez-Lazaro, Miguel A.
   Gonzalez-Martin, Julian
   Castro, Pedro
   Hospital, Teresa
   Compta, Yaroslau
   Solana, Gorka
   Gozal, David
   Otero, Jorge
TI Device for Negative Pressure Wound Therapy in Low-Resource Regions:
   Open-Source Description and Bench Test Evaluation
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE vacuum pressure therapy; wound healing; low-cost medical device; low-and
   middle-income countries; open-source hardware
ID VACUUM-ASSISTED CLOSURE
AB Background: Negative (vacuum) pressure therapy promotes wound healing. However, commercially available devices are unaffordable to most potential users in low- and middle-income countries (LMICs), limiting access to many patients who could benefit from this treatment. This study aimed to design and test a cheap and easy-to-build negative pressure device and provide its detailed open-source description, thereby enabling free replication. Methods: the negative pressure device was built using off-the-shelf materials available via e-commerce and was based on a small pump, a pressure transducer, and the simplest Arduino controller with a digital display (total retail cost <= 75 US$). The device allows the user to set any therapeutic range of intermittent negative pressure and has two independent safety mechanisms. The performance of the low-cost device was carefully tested on the bench using a phantom wound, producing a realistic exudate flow rate. Results: the device generates the pressure patterns set by the user (25-175 mmHg of vacuum pressure, 0-60 min periods) and can drain exudate flows within the clinical range (up to 1 L/h). Conclusions: a novel, low-cost, easy-to-build negative pressure device for wound healing displays excellent technical performance. The open-source hardware description provided here, which allows for free replication and use in LMICs, will facilitate the application and wider utilization of this therapy to patients.
C1 [Farre, Ramon; Rodriguez-Lazaro, Miguel A.; Otero, Jorge] Univ Barcelona, Fac Med & Ciencies Salut, Unitat Biofis & Bioengn, Barcelona 08036, Spain.
   [Farre, Ramon; Otero, Jorge] CIBER Enfermedades Resp, Madrid 28029, Spain.
   [Farre, Ramon; Castro, Pedro; Compta, Yaroslau] Inst Investigac Biomed August Pi Sunyer, Barcelona 08036, Spain.
   [Gonzalez-Martin, Julian] Univ Barcelona, ISGlobal, Hosp Clin, Microbiol Dept,CDB, Barcelona 08036, Spain.
   [Gonzalez-Martin, Julian] Inst Salud Carlos III, CIBER Infect Dis CIBERINFEC, Madrid 28029, Spain.
   [Castro, Pedro; Hospital, Teresa] Hosp Clin Barcelona, Internal Med Dept, Intens Care Unit, Barcelona 08036, Spain.
   [Compta, Yaroslau] Hosp Clin Barcelona, Inst Neurociencies, Serv Neurol, Parkinsons Dis & Movement Disorders Unit, Barcelona 08036, Spain.
   [Compta, Yaroslau] Univ Barcelona, Maeztu Ctr, Inst Neurociencies, Barcelona 08036, Spain.
   [Solana, Gorka] Univ Save, Fac Engenharias & Tecnol, Maxixe, Mozambique.
   [Gozal, David] Univ Missouri, Sch Med, Dept Child Hlth, Columbia, MO 65212 USA.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERES; University of Barcelona; Hospital Clinic de Barcelona;
   IDIBAPS; ISGlobal; University of Barcelona; Hospital Clinic de
   Barcelona; Instituto de Salud Carlos III; University of Barcelona;
   Hospital Clinic de Barcelona; University of Barcelona; Hospital Clinic
   de Barcelona; University of Barcelona; University of Missouri System;
   University of Missouri Columbia
RP Farré, R (通讯作者)，Univ Barcelona, Fac Med & Ciencies Salut, Unitat Biofis & Bioengn, Barcelona 08036, Spain.; Farré, R (通讯作者)，CIBER Enfermedades Resp, Madrid 28029, Spain.; Farré, R (通讯作者)，Inst Investigac Biomed August Pi Sunyer, Barcelona 08036, Spain.
EM rfarre@ub.edu
RI Gozal, David/ABH-3805-2020; Farre, Ramon/L-2664-2017; Castro Rebollo,
   Pedro/AAF-4792-2021; Compta, Yaroslau/U-8298-2017; Solana Arteche,
   Gorka/AAH-7925-2020; Gonzalez-Martin, Julian/AGS-6795-2022; Compta,
   Yaroslau/U-8298-2017
OI Gozal, David/0000-0001-8195-6036; Farre, Ramon/0000-0002-9084-7824;
   Castro Rebollo, Pedro/0000-0002-6118-8970; Compta,
   Yaroslau/0000-0001-6443-0104; Solana Arteche, Gorka/0000-0002-1212-0574;
   
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NR 38
TC 2
Z9 2
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2022
VL 11
IS 18
AR 5417
DI 10.3390/jcm11185417
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4S6GB
UT WOS:000857536000001
PM 36143070
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sweitzer, K
   Tomtschik, J
   Butterfield, J
   Bell, D
AF Sweitzer, Keith
   Tomtschik, Julia
   Butterfield, James
   Bell, Derek
TI Outcomes Following Use of Negative-Pressure Wound Therapy Over
   Autologous Meshed and Non-Meshed Skin Grafts
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID BURNS
AB Negative-pressure wound therapy (NPWT) over split thickness skin grafts can control exudate, decrease infection rates, and improve revascularization. However, no study specifically addresses differences in outcomes between meshed/perforated and non-meshed autologous skin grafts dressed with NPWT. Through retrospective chart review, patients undergoing autologous split thickness skin grafting with a NPWT dressing for any burn injury over a 10-month period were identified. Data on etiology, graft take, meshed/perforated or non-meshed graft, graft size, and seroma/hematoma incidence were collected. Our study included 123 patients who had STSG with NPWT and consisted of 57% males, 57% Caucasian, and an average age of 41. Burn injury etiologies consisted of scald (55%), chemical (25%), flame (15%), and contact (5%). Average 2nd degree TBSA in our cohort was 2.34%, 3rd degree TBSA 4.50%, and total TBSA 5.35%. 66.7% of patients received non-meshed grafts, and these patients had an average graft area of 76.5 cm(2). 33.3% of patients received meshed grafts, with an average graft area of 163.5 cm(2). Non-meshed burn grafts were significantly smaller than meshed grafts (P = .04). There was 100% graft take and 0% seroma/hematoma formation in all patients. Data was analyzed using an unpaired student's T test and ANOVA testing. There were no statistically significant differences in patient demographics, or burn etiology. There exist many options for dressings after repair of burn injuries, each with its own unique advantages. There were, however, no differences in graft take or incidence of seroma/hematoma formation using a NPWT dressing over autologous meshed grafts vs non-meshed grafts. Our data shows that NPWT use as a bolster dressing is safe and efficacious overlying meshed skin grafts and non-meshed grafts.
C1 [Sweitzer, Keith; Tomtschik, Julia; Butterfield, James; Bell, Derek] Univ Rochester, Dept Surg, Div Plast Surg, 601 Elmwood Ave, Rochester, NY 14642 USA.
C3 University of Rochester
RP Bell, D (通讯作者)，Univ Rochester, Dept Surg, Div Plast Surg, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM Keithsweitzer6@gmail.com; Derek_Bell@urmc.rochester.edu
RI Sweitzer, Keith/HTP-8566-2023
OI Tomtschik, Julia/0000-0001-6982-7856
CR Archer SB, 1998, J BURN CARE REHABIL, V19, P33, DOI 10.1097/00004630-199801000-00009
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   Patmo ASP, 2014, ADV WOUND CARE, V3, P383, DOI 10.1089/wound.2013.0510
NR 11
TC 2
Z9 3
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN 5
PY 2023
VL 44
IS 1
BP 136
EP 139
DI 10.1093/jbcr/irac122
EA SEP 2022
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 7S7CQ
UT WOS:000860799300001
PM 36037524
DA 2026-07-24
ER
PT J
AU Cho, J
   Hwang, H
   Song, SY
   Suh, HP
   Hong, JP
AF Cho, Jeongmok
   Hwang, Hyun
   Song, Shin Young
   Suh, Hyunsuk Peter
   Hong, Joon Pio
TI Evaluation of wound healing effects of micronized acellular dermal
   matrix in combination with negative pressure wound therapy: In vivo
   study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE collagen; gelatin; micronized acellular dermal matrix; porcine model;
   wound healing
ID DIABETIC FOOT ULCERS; EFFICACY; ENHANCE; PASTE
AB Acellular dermal matrix (ADM) grafts can provide coverage for full-thickness skin defects and substitute for dermal defects. We tested the effectiveness of micronized ADM (mADM) as a dressing material, combined with negative pressure wound therapy (NPWT), for managing superficial wounds. We compared the wound healing effect of mADM in combination with NPWT with those of gelatin and mADM applied with a foam dressing. These therapeutic materials were applied to 36 cm(2) excisional wounds in a porcine full-thickness skin defect model. Wound healing kinetics and new tissue formation were assessed 10 days after the initial treatment by measuring the wound area. Collagen deposition and neovascularization were histologically evaluated. Compared with the other two groups, mADM plus NPWT combination group had a significantly larger wound area at the baseline (P = .0040), but the smallest on the 7th day (P = .0093). In addition, collagen formation and neovascularization were more histologically promoted than in the other two groups. mADM showed better results than the gelatin group but less collagen and revascularization than the combination group, and there was no significant difference in wound area. Our results show that the combination of mADM and NPWT has a synergistic wound healing effect.
C1 [Cho, Jeongmok; Song, Shin Young; Suh, Hyunsuk Peter; Hong, Joon Pio] Univ Ulsan, Asan Med Ctr, Coll Med, Dept Plast & Reconstruct Surg, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
   [Hwang, Hyun] Emory Univ, Sch Med, Dept Pediat, Div Pediat Cardiol, Atlanta, GA USA.
   [Hwang, Hyun] Childrens Healthcare Atlanta, Atlanta, GA USA.
C3 University of Ulsan; Asan Medical Center; Emory University; Children's
   Healthcare of Atlanta (CHOA)
RP Suh, HP (通讯作者)，Univ Ulsan, Asan Med Ctr, Coll Med, Dept Plast & Reconstruct Surg, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
EM hyunsuk.suh@amc.seoul.kr
RI ; Hong, Joon/AEV-0712-2022
OI Cho, Jeong Mok/0000-0002-5957-467X; 
FU Daewoong Foundation
FX Daewoong Foundation
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   Lee M, 2020, WOUNDS, V32, P50
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   Soller EC, 2012, BIOMATERIALS, V33, P4783, DOI 10.1016/j.biomaterials.2012.03.068
   Takeo M, 2015, CSH PERSPECT MED, V5, DOI 10.1101/cshperspect.a023267
   Thompson JT, 2007, CLIN PLAST SURG, V34, P673, DOI 10.1016/j.cps.2007.07.005
   Zhang YZ, 2006, POLYMER, V47, P2911, DOI 10.1016/j.polymer.2006.02.046
NR 22
TC 9
Z9 10
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2023
VL 20
IS 4
BP 1053
EP 1060
DI 10.1111/iwj.13958
EA SEP 2022
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA A7RQ8
UT WOS:000860969600001
PM 36165089
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yang, L
   Guo, JC
   He, JP
   Shao, JF
AF Yang, Liu
   Guo, Jiachao
   He, Jinpeng
   Shao, Jingfan
TI Skin grafting treatment of adolescent lower limb avulsion injury
SO FRONTIERS IN SURGERY
LA English
DT Review
DE adolescent; avulsion; skin graft; NPWT; SCAR
ID PRESSURE WOUND THERAPY; VACUUM SEALING DRAINAGE; DERMAL REGENERATION
   TEMPLATE; MINIMALLY INVASIVE TOOL; LOWER LEG DEFECTS; OPEN CELL FOAM;
   FULL-THICKNESS; ARTIFICIAL DERMIS; BED PREPARATION; CLINICAL-EVALUATION
AB Background: Under the influence of various factors, the number of lower extremity avulsion injuries in adolescents is increasing year by year. The main modality of treatment is skin grafting. There are many types of skin grafting. Although many studies on skin grafting after avulsion injuries have been published in the past few decades, there are differences in the treatment options for adolescents with post avulsion injuries. Main body: Thorough debridement and appropriate skin grafts are essential for the surgical management of avulsion injuries for optimal prognosis. In the acquisition of grafts, progress has been made in equipment for how to obtain different depths of skin. The severity of the avulsion injury varies among patients on admission, and therefore the manner and type of skin grafting will vary. Especially in adolescents, graft survival and functional recovery are of great concern to both patients and physicians. Therefore, many efforts have been made to improve survival rate and activity. Conclusion: This review summarizes the principles of treatment of avulsion injuries, the historical development of skin grafts, and the selection of skin grafts, hoping to be helpful for future research.
C1 [Yang, Liu; Guo, Jiachao; He, Jinpeng; Shao, Jingfan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat Surg, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology
RP Shao, JF (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat Surg, Wuhan, Peoples R China.
EM shaojf65@126.com
RI He, Jinpeng/GQI-2034-2022
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NR 146
TC 1
Z9 5
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD SEP 15
PY 2022
VL 9
AR 953038
DI 10.3389/fsurg.2022.953038
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 4Z6PZ
UT WOS:000862329300001
PM 36189402
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Seidel, D
   Lefering, R
AF Seidel, Doerthe
   Lefering, Rolf
CA DiaFu Study Grp
TI NPWT resource use compared with standard moist wound care in diabetic
   foot wounds: DiaFu randomized clinical trial results
SO JOURNAL OF FOOT AND ANKLE RESEARCH
LA English
DT Article
DE Negative pressure wound therapy; Diabetic foot; Wound care; Wound;
   Resource use
ID VACUUM-ASSISTED CLOSURE; THERAPY; ULCERS; MULTICENTER
AB Background: Diabetic foot ulcers not only have a negative impact on patient mortality, morbidity and quality of life, but also require high resource utilization to achieve complete wound healing. The aim of this evaluation was to compare resource utilization of negative pressure wound therapy (NPWT) and standard moist wound care (SMWC) for diabetic foot wounds after amputation, surgical debridement or wound cleansing.
   Methods: The multicenter clinical DiaFu study enrolled 368 adults with diabetic foot ulcers between December 23, 2011 and October 21, 2014. Patients were randomly assigned to NPWT and SMWC. Evaluation of direct resource use comprised inpatient and outpatient treatment time, and personnel and material for wound treatment within 16 weeks. This resource use analysis was primarily based on the per protocol population (NPWT 44; SMWC 110).
   Results: Treatment duration was 16 days shorter with NPWT (mean (SD) 82.8 (31.6), SMWC 98.8 (24.6); U test, p = 0.001) with 14.9 days shorter outpatient treatment (mean (SD) NPWT 68.3 (31.1), SMWC 83.2 (29.7)). The number of dressing changes per study participant was lower with NPWT (mean (SD) 35.1 (18.6), SMWC (42.9 (21.4); U test, p = 0.067). Time per dressing change was significantly lower with SMWC (mean (SD) 19.7 (12.8), NPWT (16.5 (8.2) minutes; U test, p < < 0.0001). Time for surgical debridements per study participant was 23.3 minutes shorter with NPWT (mean (SD) 20.5 (20.5), SMWC (43.8 (46.7); U test, p = 0.395).
   Conclusions: Resource use was lower for NPWT, which may be an efficient treatment alternative to SMWC for diabetic foot wounds, to be demonstrated in subsequent cost analyses.
C1 [Seidel, Doerthe; Lefering, Rolf; DiaFu Study Grp] Univ Witten Herdecke, Inst Forsch Operativen Med IFOM, Ostmerheimerstr 200 Haus 38, D-51109 Cologne, Germany.
C3 Witten Herdecke University
RP Seidel, D (通讯作者)，Univ Witten Herdecke, Inst Forsch Operativen Med IFOM, Ostmerheimerstr 200 Haus 38, D-51109 Cologne, Germany.
EM DoertheSeidel@gmx.de
OI Lefering, Rolf/0000-0002-0141-1747
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL. Through a
   European tender, the study was initiated by a consortium of 19 statutory
   German health insurance funds, which provided integrated care contracts
   for all study participants and for up to 7000 patients with acute and
   chronic wounds in Germany, defined basic rules for study design based on
   the requirements of the German authorities; and provided a critical
   review of the study protocol and the final report. The study was funded
   by the manufacturers KCI (Acelity) and S&N. Both companies provided the
   NPWT devices and associated consumable supplies in the assigned regions
   of Germany as well as all necessary support and information about the
   used material. The manufacturers had no role in study design, data
   collection, data analysis, data interpretation or writing of the report.
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NR 26
TC 20
Z9 22
U1 4
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1757-1146
J9 J FOOT ANKLE RES
JI J. Foot Ankle Res.
PD SEP 30
PY 2022
VL 15
IS 1
AR 72
DI 10.1186/s13047-022-00569-w
PG 14
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 4Z7WQ
UT WOS:000862414300001
PM 36180953
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Blair, JA
   Puneky, GA
   Dickerson, TE
   Faith, HD
   Davis, JM
AF Blair, James A.
   Puneky, George A.
   Dickerson, Thomas E.
   Faith, Hayden D.
   Davis, Jana M.
TI Posttraumatic Soft Tissue Coverage of the Lower Leg for the Orthopedic
   Surgeon
SO ORTHOPEDIC CLINICS OF NORTH AMERICA
LA English
DT Review
DE Rotational flap; Gastrocnemius flap; Soleus flap; Sural flap; Limb
   salvage
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; SOLEUS MUSCLE; SURAL
   FLAP; LOWER-LIMB; RECONSTRUCTION; FOOT; MANAGEMENT; EXTREMITY; DEFECTS
AB Lower extremity trauma care is common with many patients presenting with complex soft tissue injuries. Many orthopedic surgeons perceive such soft tissue injuries to be out of their scope of practice due to presumed complexity and need for microsurgical and vascular reconstructive techniques. In this review, common approaches to treating these injuries and the ease with which these skills may be acquired and executed are discussed. Neither microsurgery nor vascular surgery is required. Methods such as DPWC, NPWT, and piecrusting serve to decrease wound tension and increase rates of successful healing through primary closure. Superficial wound coverage with STSG can provide appropriate coverage in situations in which primary wound closure is unable be obtained. As wound complexity increases, local rotational soft tissue flaps may be necessary to cover exposed bone, tendon, or implants. A multitude of courses are available in the United States and abroad to provide education in wound coverage such as The Surgical Management and Reconstructive Training (SMART) Course, Advanced Techniques in the Management of Soft Tissue (AO North America), and the Soft Tissue Coverage Skills Course (Orthopaedic Trauma Association and Limb Lengthening and Reconstruction Society). The gastrocnemius, soleus, and reverse sural artery rotational flaps prove highly resourceful to the orthopedic surgeon and negate the need for microsurgery or potential delays when working with a multidisciplinary team.
C1 [Blair, James A.; Puneky, George A.; Davis, Jana M.] Augusta Univ, Dept Orthoped Surg, Med Coll Georgia, 1120 15th St,BA 3300, Augusta, GA 30912 USA.
   [Dickerson, Thomas E.; Faith, Hayden D.] Augusta Univ, Med Coll Georgia, 1120 15th St, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University
RP Blair, JA (通讯作者)，Augusta Univ, Dept Orthoped Surg, Med Coll Georgia, 1120 15th St,BA 3300, Augusta, GA 30912 USA.
EM jamblair@augusta.edu
RI Blair, James/MIP-0917-2025
CR Albright Patrick D, 2019, OTA Int, V2, pe044, DOI [10.1097/oi9.0000000000000044, 10.1097/OI9.0000000000000044]
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NR 35
TC 0
Z9 4
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0030-5898
EI 1558-1373
J9 ORTHOP CLIN N AM
JI Orthop. Clin. North Am.
PD JUL
PY 2022
VL 53
IS 3
BP 297
EP 310
DI 10.1016/j.ocl.2022.03.002
PG 14
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 5A2GK
UT WOS:000862710300006
PM 35725038
DA 2026-07-24
ER
PT J
AU Hariri, M
   Maaz, B
   Netfagi, M
   Alawa, J
   Sattouf, A
   Dubies, HA
   Alahmad, J
   Seyitisa, MF
   Godier-Furnemont, A
   Ghali, A
   Ghandour, A
   Abdullah, Z
   Alsaleh, M
   Almousa, I
   Habib, W
   Alshaer, H
AF Hariri, Mahmoud
   Maaz, Bakry
   Netfagi, Measser
   Alawa, Jude
   Sattouf, Ahmad
   Dubies, Hussam Alden
   Alahmad, Jehad
   Seyitisa, Muhammet Fuat
   Godier-Furnemont, Amandine
   Ghali, Abedalkarem
   Ghandour, Ahmad
   Abdullah, Zohair
   Alsaleh, Munther
   Almousa, Ibrahim
   Habib, Waiel
   Alshaer, Hisham
TI Validation of a Manual Negative Pressure Wound Therapy Device
   (PragmaVAC) for Acute and Chronic Wounds: A Prospective, Randomized,
   Controlled Trial
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EVIDENCE-BASED RECOMMENDATIONS; MANAGEMENT;
   STEPS
AB Background Negative pressure wound therapy (NPWT) is an alternative to the standard gauze dressings for wound treatment. Due to limited health resources, poor electrical supply, and high costs, NPWT in resource-constrained settings is inaccessible. In conflict-affected settings, civilian injuries typically involve traumatic wounds or chronic wound infections that affect the extremities.
   Methods PragmaVAC (R) is a manually operated NPWT device designed to increase accessibility to NPWT without the need of electrical power. We aimed to determine the clinical efficacy of PragmaVAC through a controlled, non-blinded open-label clinical trial in a resource-constrained locality. The endpoint was formation of granulation tissue sufficient for wound closure.
   Results Fifty-nine patients qualified for analysis (19 Gauze; 40 PragmaVAC). The mean age of participants was 49.25 years, 55.9% were male, and 42.4% were diabetic. Forty three wounds (72.9%) were acute, 44 wounds (74.6%) were clean-contaminated, and 34 wounds (57.6%) were localized to the lower limb. The average duration of treatment was 15.3 days in PragmaVAC vs 36.5 days in control, p = 0.013. Similarly, PragmaVAC required fewer number of dressing changes 2.7 vs 23.2 times, p < 0.0001, at a lower frequency of dressings 0.22/day vs 0.73/day, in the control group, p < 0.0001.
   Conclusions PragmaVAC is associated with accelerated healing and less frequent requirement of dressing changes. The introduction of a manually operated, low-cost device in resource-constrained settings presents an opportunity to improve wound care outcomes, decrease interventions, and optimize usage of material and human resources.
C1 [Hariri, Mahmoud; Seyitisa, Muhammet Fuat; Alshaer, Hisham] Pragmat Innovat Inc, Mississauga, ON, Canada.
   [Hariri, Mahmoud; Alahmad, Jehad] Syrian Board Med Specialties SBOMS, Gaziantep, Turkey.
   [Maaz, Bakry; Ghali, Abedalkarem; Alsaleh, Munther] Mohamed Waseem Maaz Hosp, Northern Aleppo, Syria.
   [Netfagi, Measser; Ghandour, Ahmad; Abdullah, Zohair] Rahma Darkoush Hosp, Darkoush, Syria.
   [Alawa, Jude] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
   [Dubies, Hussam Alden; Alahmad, Jehad; Almousa, Ibrahim] Idleb Surg Hosp, Idleb, Syria.
   [Godier-Furnemont, Amandine] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA.
   [Sattouf, Ahmad; Habib, Waiel] Idleb Cent Hosp, Idleb, Syria.
C3 Stanford University; University of California System; University of
   California San Francisco
RP Hariri, M (通讯作者)，Pragmat Innovat Inc, Mississauga, ON, Canada.; Hariri, M (通讯作者)，Syrian Board Med Specialties SBOMS, Gaziantep, Turkey.
EM m.hariri@sboms.org
RI ; Alawa, Jude/QJX-2484-2026
OI Godier-Furnemont, Amandine/0000-0002-3613-0881; Alawa,
   Jude/0000-0003-3600-4356; Alshaer, Hisham/0000-0001-6736-2215; 
FU Creating Hope in Conflict: a Humanitarian Grand Challenge; USAID, The UK
   Government; Ministry of Foreign Affairs of the Netherlands; Global
   Affairs Canada; Grand Challenges Canada
FX This project is supported by Creating Hope in Conflict: a Humanitarian
   Grand Challenge; a partnership of USAID, The UK Government, the Ministry
   of Foreign Affairs of the Netherlands, and Global Affairs Canada, with
   support from Grand Challenges Canada.
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NR 21
TC 2
Z9 3
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD DEC
PY 2022
VL 46
IS 12
BP 2946
EP 2953
DI 10.1007/s00268-022-06713-8
EA SEP 2022
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5Y1GG
UT WOS:000863173500004
PM 36175648
DA 2026-07-24
ER
PT J
AU Miyanaga, A
   Miyanaga, T
   Sakai, K
   Konya, C
   Asano, K
   Shimada, K
AF Miyanaga, Aiko
   Miyanaga, Toru
   Sakai, Keiko
   Konya, Chizuko
   Asano, Kimi
   Shimada, Kenichi
TI Patient experience of negative pressure wound therapy: A qualitative
   study
SO NURSING OPEN
LA English
DT Article
DE negative pressure wound therapy; patient experience; qualitative study;
   wound healing
ID VACUUM-ASSISTED CLOSURE; NPWT
AB Aim: This study aimed to clarify the treatment experience of patients undergoing negative pressure wound therapy (NPWT).
   Design: This study used a qualitative design.
   Methods: Seventeen inpatients were semi-structured interviewed about their experiences of treatment with negative pressure wound therapy.
   Results: Inpatients' answers were categorized into seven themes: pain and discomfort associated with treatment, physical limitations owing to attached device, mental burden owing to the odour and noises of the attached device, social limitations owing to the attached device, advances in medical care and science, device personification and mixed feelings towards medical staff. The patients were able to tolerate the aforementioned limitations while feeling attachment and gratitude towards the device created through advances in medical care and science, and towards medical staff who helped them heal. In the future, we plan to develop an NPWT care guide.
C1 [Miyanaga, Aiko; Sakai, Keiko; Asano, Kimi] Kanazawa Med Univ, Dept Sch Nursing, Uchinada, Ishikawa, Japan.
   [Miyanaga, Toru; Shimada, Kenichi] Kanazawa Med Univ, Dept Plast Surg, Uchinada, Ishikawa, Japan.
   [Konya, Chizuko] Ishikawa Prefectural Nursing Univ, Dept Nursing, Kahoku, Ishikawa, Japan.
C3 Kanazawa Medical University; Kanazawa Medical University
RP Miyanaga, A (通讯作者)，Kanazawa Med Univ, 1-1 Daigaku, Kahoku, Ishikawa 9200293, Japan.
EM aiko3000@kanazawa-med.ac.jp
OI Miyanaga, Aiko/0000-0002-1512-6293
FU Department of Cardiovascular Surgery, General and Digestive Surgery
   Plastic, and Reconstructive Surgery at Kanazawa Medical University
   Hospital; Grants-in-Aid for Scientific Research [20K10647] Funding
   Source: KAKEN
FX We would like to thank all participants for sharing their experiences.
   We also wish to express gratitude to the Department of Cardiovascular
   Surgery, General and Digestive Surgery Plastic, and Reconstructive
   Surgery at Kanazawa Medical University Hospital for supporting this
   research.
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   Bolas Niamh, 2012, Br J Community Nurs, VSuppl, pS30
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NR 19
TC 15
Z9 15
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2054-1058
J9 NURS OPEN
JI NURS. OPEN
PD MAR
PY 2023
VL 10
IS 3
BP 1415
EP 1425
DI 10.1002/nop2.1392
EA OCT 2022
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 9A0XB
UT WOS:000864024800001
PM 36199166
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhao, YH
   Feng, YH
   Deng, HT
   Huang, WQ
   Xu, LH
   Meng, XP
   Xie, XG
AF Zhao, Yao-Hua
   Feng, Yu-Hong
   Deng, Hai-Tao
   Huang, Wei-Qi
   Xu, Li-Hong
   Meng, Xian-Ping
   Xie, Xu-Gang
TI Therapeutic strategies for retention of cranioplasty titanium mesh after
   mesh exposure
SO ACTA NEUROCHIRURGICA
LA English
DT Article
DE Skull; Plastic surgery; Negative pressure wound therapy; Titanium;
   Prosthesis retention
ID AFFECTING GRAFT INFECTION
AB Background Titanium mesh exposure after cranioplasty is a possible complication and is usually managed by mesh removal and flap transfer, but the advantages of the rigid prosthesis are then lost. This study aimed to present our experience with negative pressure wound therapy combined with soft tissue dilation for retaining the titanium mesh in patients with mesh exposure after cranioplasty. Methods This retrospective study included patients treated between 01/2016 and 05/2019 at the Jiangyin Hospital Affiliated to Southeast University School of Medicine. The wound was cleaned, and a cystic space was created for the tissue dilator, which was used with a self-designed negative pressure dressing. After the target dilation was achieved, the repair was conducted while retaining the titanium mesh. Results Eight patients were included (seven males and one female; 53.6 +/- 8.8 (range, 43-65) years of age). The exposed mesh area ranged from 1 x 1 to 4 x 5.5 cm. The thinning scalp area around the exposed mesh ranged from 3.6 x 3.8 to 4 x 5.5 cm. Five patients had positive wound cultures and received sensitive antibiotics. The dilator embedding time was 20-28 days. The time of negative pressure wound therapy was 25-33 days. The hospital stay was 30-41 days. Primary wound healing was achieved in all eight patients. There were no signs of recurrence after 6-18 months of follow-up. The cranial CT scans were unremarkable. Conclusions Negative pressure wound therapy combined with soft tissue dilation for exposed titanium mesh after cranioplasty might help retain the titanium mesh.
C1 [Zhao, Yao-Hua; Deng, Hai-Tao; Huang, Wei-Qi; Xu, Li-Hong] Southeast Univ, Jiangyin Hosp, Sch Med, Dept Burn & Plast Surg, Jiangyin, Jiangsu, Peoples R China.
   [Feng, Yu-Hong] Southeast Univ, Jiangyin Hosp, Sch Med, Dept Nursing, Jiangyin, Jiangsu, Peoples R China.
   [Meng, Xian-Ping; Xie, Xu-Gang] Southeast Univ, Jiangyin Hosp, Sch Med, Dept Radiol, Jiangyin, Jiangsu, Peoples R China.
C3 Southeast University - China; Southeast University - China; Southeast
   University - China
RP Zhao, YH (通讯作者)，Southeast Univ, Jiangyin Hosp, Sch Med, Dept Burn & Plast Surg, Jiangyin, Jiangsu, Peoples R China.
EM zfh3r@sohu.com
FU Science and Technology Innovation Special Fund of Jiangyin, Jiangsu
   province [JY0603-020118-0014 PB]
FX This study was funded by the Science and Technology Innovation Special
   Fund of Jiangyin, Jiangsu province (grant number JY0603-020118-0014 PB).
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NR 21
TC 4
Z9 7
U1 0
U2 9
PU SPRINGER WIEN
PI Vienna
PA Prinz-Eugen-Strasse 8-10, A-1040 Vienna, AUSTRIA
SN 0001-6268
EI 0942-0940
J9 ACTA NEUROCHIR
JI Acta Neurochir.
PD DEC
PY 2022
VL 164
IS 12
BP 3101
EP 3106
DI 10.1007/s00701-022-05365-w
EA OCT 2022
PG 6
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 6O0JN
UT WOS:000865673300001
PM 36214913
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Qian, YY
   He, D
   Qi, HZ
   Zhang, T
   Fu, T
   Yu, MH
   Yan, Q
   Cai, ZY
   Liu, YM
AF Qian, Yuanyi
   He, Di
   Qi, HaoZhao
   Zhang, Tian
   Fu, Tao
   Yu, Menghua
   Yan, Qin
   Cai, Zhuoying
   Liu, Yanming
TI Comparative Study of Multifunctional Irrigation-assisted Vacuum
   Drainage, Vacuum Sealing Drainage and the Penrose Drain in Treating
   Severe Multi-space Deep Fascial Infection in the Head and Neck
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID PRESSURE-WOUND-THERAPY; ODONTOGENIC INFECTIONS; SPACE INFECTIONS;
   MANAGEMENT; IMPACT
AB Background We aimed to compare multifunctional irrigation-assisted vacuum drainage (MIVD), vacuum sealing drainage (VSD) and the Penrose drain in treating severe multi-space deep fascial infection (DFI) in head and neck. Methods A retrospective study was conducted on 113 patients who had suffered from severe multi-space DFI in head and neck and underwent surgical treatment. Patients were divided into the MIVD group, the VSD group, and the Penrose group according to their treatment. Baseline characteristics and clinical outcome data regarding infection control, clinicians' workload, surgical procedure required, and cost were analyzed. Results Duration of antibiotic administration was significantly shorter using MIVD and VSD than Penrose drains (p = 0.002 with MIVD, p = 0.008 with VSD). Hospital stay in the MIVD group was shorter than the Penrose group (p = 0.034). Compared to the other two groups, more times of manual irrigation were needed in higher frequency in the Penrose group (p < 0.001). Longer Incision and more surgical operation were required in the VSD group than the other two groups (p < 0.001). The treatment cost in the VSD group was higher than the MIVD group (p = 0.045) and the Penrose group (p < 0.001). Conclusions In the treatment of severe multi-space DFI in head and neck, MIVD and VSD are superior to the Penrose drain in infection control and reduction in clinicians' workload. Meanwhile, MIVD, with fewer surgical procedures required and less cost, seems to be a more promising method than VSD.
C1 [Qian, Yuanyi; He, Di; Qi, HaoZhao; Zhang, Tian; Fu, Tao; Yu, Menghua; Yan, Qin; Cai, Zhuoying; Liu, Yanming] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Oral & Maxillofacial Surg, 88 Jiefang Rd, Hangzhou 310009, Peoples R China.
C3 Zhejiang University
RP Liu, YM (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Oral & Maxillofacial Surg, 88 Jiefang Rd, Hangzhou 310009, Peoples R China.
EM liuyanming@zju.edu.cn
OI , Yuanyi/0000-0002-0001-4221
FU Fund of Basic Public Welfare Research Program of Zhejiang Province
   [LGF21H140002]; Joint Foundation for Key Program of Medical Health
   Science and Technology Project of Zhejiang Provincial Health Commission;
   National Health and Family Planning Commission of the People's Republic
   of China [WKJ-ZJ-1718]
FX This study was supported by the Fund of Basic Public Welfare Research
   Program of Zhejiang Province (LGF21H140002) and Joint Foundation for Key
   Program of Medical Health Science and Technology Project of Zhejiang
   Provincial Health Commission and National Health and Family Planning
   Commission of the People's Republic of China (WKJ-ZJ-1718).
CR Adeyemo WL, 2021, J MAXILLOFAC ORAL SU, V20, P149, DOI 10.1007/s12663-020-01336-9
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NR 25
TC 6
Z9 7
U1 3
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD DEC
PY 2022
VL 46
IS 12
BP 2973
EP 2983
DI 10.1007/s00268-022-06758-9
EA OCT 2022
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5Y1GG
UT WOS:000865711900002
PM 36216895
DA 2026-07-24
ER
PT J
AU Wang, T
   Fan, LH
   Liu, JJ
   Tao, Y
   Li, X
   Wang, XJ
   Li, LM
AF Wang, Tao
   Fan, Longhua
   Liu, Jianjun
   Tao, Yue
   Li, Xu
   Wang, Xiaojun
   Li, Limeng
TI Negative Pressure Wound Therapy Promotes Wound Healing by Inhibiting
   Inflammation in Diabetic Foot Wounds: A Role for NOD1 Receptor
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article; Early Access
DE negative pressure wound therapy; NOD1 receptor; diabetic patients;
   inflammation
AB Aims: Diabetic foot results in frequent amputation and quality-of-life reduction in diabetes population. These lesions are featured by a prolonged and exaggerated inflammation with a significant impairment in local bacterial invasion. Negative pressure wound therapy (NPWT) attenuates hyperinflammation in the healing of diabetic foot wounds, but the potential mechanism of NPWT down-regulated inflammatory reaction still remains elusive. This study aims to explore the inflammatory signaling involved in the effect of NPWT on diabetic ulcer. Methods: Thirty patients with diabetic foot ulceration were divided into NPWT group (treated with NPWT, n = 10), NPWT + FK565 group (treated with NPWT combined with FK565 which is NOD1 receptor ligand, n = 10) and control group (n = 10). After two weeks treatment, samples were harvested and analyzed by histochemistry for infiltration of inflammatory cells, immunofluorescence stain for NOD1, western blotting for NOD1, RIP2 (Receptor interacting protein 2), IL-1 beta, TAK1 (Transforming growth factor-beta-activated kinase1), p65 and real time-PCR for expression of NOD1 and RIP2. Results: NPWT could notably accelerate the diabetic wound healing through alleviating inflammatory reaction. The immunofluorescence analysis results revealed that NOD1 was mainly expressed in the cytoplasm and noticeably decreased after the NPWT treatment. And NPWT obviously decreased both the mRNA and protein level of NOD1 and RIP2. Moreover, The protein expression of IL-1 beta, TAK1 and p65 in the NPWT-group were significant decreased. Conclusion: NPWT effectively promotes wound healing by suppressing the wound inflammation in diabetic foot, which is mediated at least in part by suppression of NOD1 receptor.
C1 [Wang, Tao; Fan, Longhua; Liu, Jianjun; Tao, Yue; Li, Xu; Wang, Xiaojun; Li, Limeng] Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, Qingpu Branch, Shanghai, Peoples R China.
C3 Fudan University
RP Fan, LH (通讯作者)，Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, Qingpu Branch, Shanghai, Peoples R China.
EM fanlonghua@163.com
RI Liu, Jianjun/AAK-4989-2020
OI , Wang/0000-0001-5462-2970
FU Hygiene and Health Commission of Qingpu District, Science and Technology
   Commission of Qingpu District, Shanghai Health Committee General
   Project, Shanghai Health Committee Youth Project [w2020-11, QKY201914,
   202040062, 202140227, 20194Y0286]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Hygiene and Health Commission of Qingpu District,
   Science and Technology Commission of Qingpu District, Shanghai Health
   Committee General Project, Shanghai Health Committee Youth Project,
   (grant number w2020-11, QKY201914, 202040062, 202140227, 20194Y0286).
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NR 31
TC 3
Z9 5
U1 0
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD 2022 OCT 11
PY 2022
DI 10.1177/15347346221131844
EA OCT 2022
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 5F3HA
UT WOS:000866208300001
PM 36221954
DA 2026-07-24
ER
PT J
AU Petca, A
   Rotar, IC
   Borislavschi, A
   Petca, RC
   Danau, RA
   Dumitrascu, MC
   Sandru, F
   Pacu, I
AF Petca, Aida
   Rotar, Ioana Cristina
   Borislavschi, Andreea
   Petca, Razvan-Cosmin
   Danau, Razvan Alexandru
   Dumitrascu, Mihai Cristian
   Sandru, Florica
   Pacu, Irina
TI Adapting surgical 'bundles' to prevent surgical site infections in
   obstetrics and gynecology (Review)
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Review
DE surgical site infection; vacuum-assisted closure therapy; surgery;
   obstetrics; gynecology
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; SURGERY; REDUCE
AB Surgical site infections (SSIs) are a complication in any surgical field and they are responsible for 38% of surgery-related patient deaths. Identifying appropriate prophylaxis and solutions to combat SSIs is of global interest. Several studies and reports on SSI raise awareness of this costly complication, both in terms of physical and mental suffering, and as a monetary burden. Knowing the risk factors and implementing strategies to reduce SSI risk represent an adequate approach to reduce SSI incidence. General risk factors of SSI are applicable in the obstetrics and gynecology field, alongside its specific characteristics, including immunological changes occurring during pregnancy, as well as disturbances of vaginal microbiota. The risk of SSI is determined by patient factors but also by preoperative, intraoperative and postoperative care. 'Bundle' prevention strategies have been smartly adopted and their efficiency has been demonstrated in colorectal surgery, cesarean deliveries and gynecological oncology surgeries. 'Bundle' measures may vary among studies, but they remain important prevention methods, which contribute to decreasing SSIs, which is a favorable outcome, and thus, are increasingly used as a routine practice. Therefore, healthcare personnel should aim for the early identification of risk factors to minimize the risk of SSI. All evidence-based methods for preventing and treating SSIs in all surgical fields should be considered to be integral components in order for the best care to be provided to patients.
C1 [Petca, Aida; Dumitrascu, Mihai Cristian; Sandru, Florica; Pacu, Irina] Carol Davila Univ Med & Pharm, Dept Obstet & Gynecol, Bucharest 050474, Romania.
   [Petca, Aida; Borislavschi, Andreea] Elias Emergency Univ Hosp, Dept Obstet & Gynecol, Bucharest 011461, Romania.
   [Rotar, Ioana Cristina] Iuliu Hatieganu Univ Med & Pharm, Dept Obstet & Gynaecol 1, Cluj Napoca 400012, Romania.
   [Rotar, Ioana Cristina] Emergency Clin Cty Hosp Cluj Napoca, Dept Obstet & Gynecol, Cluj Napoca 400006, Romania.
   [Petca, Razvan-Cosmin; Danau, Razvan Alexandru] Carol Davila Univ Med & Pharm, Dept Urol, Bucharest 050474, Romania.
   [Petca, Razvan-Cosmin; Danau, Razvan Alexandru] Prof Dr Th BurgheleClin Hosp, Dept Urol, Bucharest 050659, Romania.
   [Dumitrascu, Mihai Cristian] Univ Emergency Hosp, Dept Obstet & Gynecol, Bucharest 050098, Romania.
   [Sandru, Florica] Elias Emergency Univ Hosp, Dept Dermatol, Bucharest 011461, Romania.
   [Pacu, Irina] Sf Pantelimon Emergency Clin Hosp, Dept Obstet & Gynecol, Bucharest 021623, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Carol Davila University of Medicine &
   Pharmacy
RP Borislavschi, A (通讯作者)，Elias Emergency Univ Hosp, Dept Obstet & Gynecol, Bucharest 011461, Romania.
EM andreeaborislavschi@gmail.com; razvan.danau@umfcd.ro
RI pacu, irina/E-8545-2019; rotar, ioana/AGD-1880-2022; Danau,
   Razvan/HJY-8563-2023; Borislavschi, Andreea/HMD-4904-2023; Sandru,
   Florica/JUV-4700-2023; Petca, Răzvan-Cosmin/AAH-2462-2020; Petca,
   Aida/AAM-9912-2020
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NR 48
TC 5
Z9 5
U1 0
U2 14
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD NOV
PY 2022
VL 24
IS 5
AR 695
DI 10.3892/etm.2022.11631
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 5I3FW
UT WOS:000868247900001
PM 36277147
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Nie, PF
   Zhang, CH
AF Nie, Pengfei
   Zhang, Canhong
TI Effect of Vacuum Sealing Drainage on Soft Tissue Injury of Traumatic
   Fracture and Its Effect on Wound Recovery
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID HIP DISLOCATION; THERAPY; EPIDEMIOLOGY; STRAINS
AB Purpose. The current work is mainly to explore the effect of vacuum sealing drainage (VSD) on soft tissue injury (STI) caused by traumatic fractures (TFs) and its effect on wound recovery. Methods. We first selected 90 patients with TF STI from May 2019 to May 2021, of which 40 patients (control group) received routine treatment, and the other 50 patients (observation group) were treated with VSD. The curative effect, rehabilitation (changing dressing frequency, healing time, and hospitalization time), pain severity, patient comfort, and complications were evaluated and compared. Results. The observation group exhibited a higher total effective rate, lower dressing change frequency, complication rate, and shorter healing time and hospital stay than the control group, which are statistically significant. Statistically milder pain sensation and better patient comfort were also determined in the observation group. Conclusions. VSD is effective and safe in the treatment of TF-induced sexually transmitted infections, which can effectively accelerate wound recovery while reducing pain sensation and improving patient comfort, with clinical promotion value.
C1 [Nie, Pengfei] Beilun Dist Peoples Hosp, Dept Orthoped, Ningbo 315800, Zhejiang, Peoples R China.
   [Zhang, Canhong] Fujian Med Univ, Quanzhou Hosp 1, Dept Orthopaed, Quanzhou 362000, Fujian, Peoples R China.
C3 Fujian Medical University
RP Nie, PF (通讯作者)，Beilun Dist Peoples Hosp, Dept Orthoped, Ningbo 315800, Zhejiang, Peoples R China.
EM niepengfei188@163.com; zhangch1988@126.com
FU Ningbo Beilun People's Hospital Fund;  [2022YJJJYB04]
FX The subject in Beilun District people's Hospital and A preliminary study
   on mechanical analysis of fracture around clavicular hook Ningbo Beilun
   People's Hospital Fund (2022YJJJYB04).
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   Tang Juyu, 2019, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V33, P467, DOI 10.7507/1002-1892.201811103
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   Zhang L, 2020, EXP THER MED, V20, P2305, DOI 10.3892/etm.2020.8941
   Zhong MJ, 2021, ORTHOP SURG, V13, P1828, DOI 10.1111/os.13106
NR 33
TC 5
Z9 7
U1 1
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD SEP 29
PY 2022
VL 2022
AR 7107090
DI 10.1155/2022/7107090
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 5I4JM
UT WOS:000868325000002
PM 36212953
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Cangel, U
   Sirekbasan, S
   Polat, E
AF Cangel, Ugur
   Sirekbasan, Serhat
   Polat, Erdal
TI Comparison of Larval Therapy and Vacuum-Assisted Closure Therapy after
   Revascularization in Peripheral Artery Disease Patients with Ischemic
   Wounds
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID MAGGOT DEBRIDEMENT THERAPY; CARDIOVASCULAR-DISEASE; PRESSURE; FOOT
AB Objective. Even for very successful peripheral revascularization therapy, treatment is not complete until the ulcerative, gangrenous, and infected wound is closed. This study was performed and compared the outcomes of vacuum-assisted closure (VAC) and maggot debridement therapy (MDT) following peripheral revascularization to accelerate the wound healing process. Methods. We did a prospective randomized clinical trial between January 1, 2014, and June 21, 2019. This study included 72 patients (63 males and nine females). Balloon angioplasty was performed in 21 patients (29.2%), peripheral bypass in 39 (54.2%), and both balloon angioplasty and revascularization (hybrid) surgery in 12 (16.7%). Thirty-three patients (45.8%) received 15 VAC therapy sessions for a month. Therapy progress was monitored at 48 h intervals, and wound debridement was performed. Thirtynine patients (54.2%) received an average of six larval therapy sessions for a month. Groups were compared with the X-2 test, and a statistically significant difference was found (P < 0.001). Results. In the VAC therapy group (n = 33), 14 patients (42.4%) had their feet amputated, 5 (15.1%) had a toe amputated, and 4 (12.1%) had all of their toes amputated. A skin graft was performed on four patients (12.1%) who developed granulation tissue. The wounds of six patients (18.2%) undergoing VAC therapy healed. In the larval therapy group (n = 39), the wounds healed in 36 patients (92.3%), and 3 (7.7%) had a toe amputated. Conclusion. Larval therapy was shown to be more effective than VAC therapy for the treatment of postrevascularization ischemic wounds. Thus, larval therapy can be used as an effective biological treatment method when major amputation is not required.
C1 [Cangel, Ugur] Bahcesehir Univ, Med Fac, Dept Cardiovasc Surg, Istanbul, Turkey.
   [Sirekbasan, Serhat] Cankiri Karatekin Univ, Eldivan Vocat Sch Hlth Serv, Dept Med Lab Tech, Cankiri, Turkey.
   [Polat, Erdal] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Med Microbiol, Istanbul, Turkey.
C3 Bahcesehir University; Cankiri Karatekin University; Istanbul University
   - Cerrahpasa
RP Sirekbasan, S (通讯作者)，Cankiri Karatekin Univ, Eldivan Vocat Sch Hlth Serv, Dept Med Lab Tech, Cankiri, Turkey.
EM serhatsirekbasan@gmail.com
RI Polat, Erdal/D-7602-2019; Sirekbasan, Serhat/Q-1093-2018
OI Cangel, Uğur/0009-0007-4941-3438; Sirekbasan, Serhat/0000-0001-7967-3539
CR Aiello A, 2014, NUTR METAB CARDIOVAS, V24, P355, DOI 10.1016/j.numecd.2013.12.007
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NR 25
TC 3
Z9 4
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD MAR 29
PY 2022
VL 2022
AR 8148298
DI 10.1155/2022/8148298
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 5L1XY
UT WOS:000870210700007
PM 35392647
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Kaçmaz, HY
   Baser, M
   Sozuer, EM
AF Kacmaz, Hatice Yuceler
   Baser, Muruvvet
   Sozuer, Erdogan Mutevelli
TI Effect of Prophylactic Negative-Pressure Wound Therapy for High-Risk
   Wounds in Colorectal Cancer Surgery: A Randomized Controlled Trial
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE colorectal surgery; negative-pressure wound therapy; NPWT; surgical site
   infection; surgical wound complications; wound care
ID SURGICAL SITE INFECTION; POSTOPERATIVE COMPLICATIONS; GENERAL-SURGERY;
   LAPAROTOMY; MORTALITY; PREVENTION; MORBIDITY; COLECTOMY; INCISIONS;
   ASEPSIS
AB OBJECTIVE: To determine the effect of prophylactic negative-pressure wound therapy (pNPWT) in patients at high risk of surgical wound complications (SWCs) who underwent colorectal cancer (CRC) surgery.
   METHODS: In an open-label randomized controlled trial, 50 patients who underwent open CRC surgery between November 2018 and February 2020 were included. Participants were randomly assigned to the pNPWT group (n = 24) or control group (n = 26). For patients in the pNPWT group, the pNPWT device was placed on the wound for 7 days, whereas for patients in the control group, the wound was covered with a sterile gauze dressing. The primary outcome measured was 30-day SWCs: surgical site infection, hematoma, seroma, and wound dehiscence/evisceration. Secondary outcomes included postoperative wound infection assessment score and length of postoperative hospital stay.
   RESULTS: The incidence of 30-day SWCs differed significantly between the pNPWT and control groups (16.7% vs 53.8% respectively, P = .006). Patients in the pNPWT group had a significantly lower incidence of seroma than did those in the control group (8.3% vs 34.6%, P = .025). Surgical site infection occurred in 10 of 50 patients (20%) in the study: two (8.3%) in the pNPWT group and eight (30.8%) in the control group (P = .048). No hematomas or wound dehiscence/evisceration were noted in the study. There was no difference in median length of stay between groups (P = .153).
   CONCLUSIONS: This study confirmed that pNPWT effectively helps prevent SWCs in high-risk wounds after open CRC surgery.
C1 [Kacmaz, Hatice Yuceler] Erciyes Univ Kayseri, Dept Surg Dis Nursing, Kayseri, Turkey.
   [Baser, Muruvvet; Sozuer, Erdogan Mutevelli] Erciyes Univ Kayseri, Dept Gen Surg, Kayseri, Turkey.
C3 Erciyes University; Erciyes University
RP Kaçmaz, HY (通讯作者)，Erciyes Univ Kayseri, Dept Surg Dis Nursing, Kayseri, Turkey.
RI BASER, MURUVVET/AAL-7603-2021; Yüceler Kaçmaz, Hatice/AAL-6992-2021
OI Yüceler Kaçmaz, Hatice/0000-0003-4529-1991
CR Alves A, 2005, ARCH SURG-CHICAGO, V140, P278, DOI 10.1001/archsurg.140.3.278
   [Anonymous], 2017, COLORECTAL CANC FACT
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   Genser L, 2019, DIGEST SURG, V37, P1
   Harris CL, 2018, FDN BEST PRACTICE SK, P1
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   Pellino G, 2014, INT J SURG, V12, pS64, DOI 10.1016/j.ijsu.2014.08.378
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   Shen P, 2017, J AM COLL SURGEONS, V224, P726, DOI 10.1016/j.jamcollsurg.2016.12.028
   Tevis SE, 2016, CLIN COLON RECT SURG, V29, P246, DOI 10.1055/s-0036-1584501
   Thamilselvam P, 2017, JOJ NURSE HLTH CARE, V2
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NR 39
TC 6
Z9 9
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2022
VL 35
IS 11
BP 597
EP 603
DI 10.1097/01.ASW.0000874168.60793.10
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 5L5BA
UT WOS:000870427600008
PM 36264751
DA 2026-07-24
ER
PT J
AU Spicka, P
   Chudácek, J
   Rezac, T
   Vomácková, K
   Ambroz, R
   Molnár, J
   Klos, D
   Vrba, R
AF Spicka, Petr
   Chudacek, Josef
   Rezac, Tomas
   Vomackova, Katherine
   Ambroz, Radek
   Molnar, Jan
   Klos, Dusan
   Vrba, Radek
TI Prognostic significance of comorbidities in patients with diffuse
   peritonitis
SO EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
LA English
DT Article
DE Peritonitis; Type of effusion; Comorbidity; Narrow presure wound
   therapy; Vacuum assisted closure
ID MORTALITY
AB Background Diffuse peritonitis is a severe disease with high mortality and morbidity rates. Therapy is fundamentally surgical. It is important to identify patients with a significantly worse prognosis and patients who may benefit from more aggressive surgical and postsurgical care such as NPWT (Narrow Pressure Wound Therapy) prior to surgery. We tried to identify a determining factor for higher morbidity and mortality rates resulting in a worse prognosis among initial data and patient comorbidities in order to focus therapy towards more aggressive surgical management. Methods In a group of 274 patients with diffuse peritonitis, we evaluated the type of peritonitis according to effusion, origin, surgery type, and the age, gender, and present comorbidities of the patients, and compared it with the overall mortality, morbidity rate, and duration of hospitalization. Results Patients without comorbidities had a significantly lower burden in both morbidity and mortality. We recorded the highest difference in mortality in patients with two or more comorbidities, with pulmonary and cardiovascular diseases, with malignancy and hypertension. Morbidity was found to be significantly exacerbated by the presence of two or more severe diseases, cardiovascular disease, malignancy, and hypertension. Conclusion We identified age, effusion type, and the presence of comorbidities as key factors for the prognosis of our patients-the morbidity and mortality rates were substantially increased in patients with two or more comorbidities, as well as by the presence of cardiovascular disease, malignancy, and hypertension. A more aggressive approach should be considered to improve the prognosis in these patients.
C1 [Spicka, Petr; Rezac, Tomas; Vomackova, Katherine; Ambroz, Radek; Molnar, Jan; Klos, Dusan; Vrba, Radek] Palacky Univ, Fac Med & Dent, Dept Surg, Hnevotinska 976-3, Olomouc 77515, Czech Republic.
   [Chudacek, Josef] Olomouc Univ Hosp, Dept Surg, IP Pavlova 185-6, Olomouc 77900, Czech Republic.
C3 Palacky University Olomouc; University Hospital Olomouc
RP Vrba, R (通讯作者)，Palacky Univ, Fac Med & Dent, Dept Surg, Hnevotinska 976-3, Olomouc 77515, Czech Republic.
EM radek.vrba@fnol.cz
RI ; Spicka, Petr/AAE-2392-2022; Vrba, Radek/AAE-3079-2022; Řezáč,
   Tomáš/AAX-4241-2021
OI Ambrož, Radek/0000-0002-5572-3148; Spicka, Petr/0000-0003-3166-2624; 
CR Anaya Daniel A, 2003, Surg Infect (Larchmt), V4, P355, DOI 10.1089/109629603322761418
   Berreta Julio, 2010, Acta Gastroenterol Latinoam, V40, P105
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   Nag DS, 2019, WORLD J CLIN CASES, V7, P2227, DOI 10.12998/wjcc.v7.i16.2227
   Saunders DI, 2012, BRIT J ANAESTH, V109, P368, DOI 10.1093/bja/aes165
   Schwarz A, 2007, EUR J MED RES, V12, P200
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   Tartaglia D, 2021, UPDATES SURG, V73, P1975, DOI 10.1007/s13304-021-01012-8
   Tolonen M, 2016, LANGENBECK ARCH SURG, V401, P611, DOI 10.1007/s00423-016-1454-8
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   WINKELTAU G, 1992, CHIRURG, V63, P1035
NR 16
TC 2
Z9 4
U1 0
U2 3
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 1682-8631
EI 1682-4016
J9 EUR SURG
JI Eur. Surg.
PD DEC
PY 2022
VL 54
IS 6
BP 309
EP 316
DI 10.1007/s10353-022-00780-w
EA OCT 2022
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6N4OH
UT WOS:000870663700001
OA hybrid
DA 2026-07-24
ER
PT J
AU Naude, L
   Balenda, G
   Lombaard, A
AF Naude, L.
   Balenda, G.
   Lombaard, A.
TI Autologous whole blood clot and negative-pressure wound therapy in South
   Africa: A comparison of the cost and social considerations
SO SAMJ SOUTH AFRICAN MEDICAL JOURNAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; MANAGEMENT; CARE;
   MULTICENTER; EFFICACY; HEALTH; SKIN
AB Background. Advanced wound treatment modalities enhance healing of hard-to-heal wounds, decrease the risk of amputations, and improve the quality of life of patients. Modalities have different rates of efficacy and incur different social and financial costs to the individual and the healthcare system. Two such modalities, the autologous whole blood clot (WBC) and negative-pressure wound therapy (NPWT), were compared in the South African (SA) context. The comparison was conducted on hard-to-heal wounds, with a specific focus on diabetic foot ulcers (DFUs).Objectives. To compare the social considerations and financial costs of using autologous WBC v. NPWT in the treatment of DFUs in SA. Methods. Data were obtained based on current supply costs from SA suppliers for the two modalities, the standard of care for both modalities, the number of applications required for each, and social considerations provided by SA wound management clinicians. Wound healing rates were obtained from the published literature. This information was used to calculate costs of two scenarios (scenario 1: low exudate v. scenario 2: high exudate), which were compared over two treatment durations (4 and 12 weeks) for each treatment modality. Calculations included weekly cost of supplies, total cost saved by a patient with a DFU managed with either of the wound therapies, and the difference in total cost saved between the two modalities. Key social considerations were assessed qualitatively from discussions with SA clinicians experienced in both autologous WBC and NPWT, and from published research.Results. The cost of supplies per week was ZAR3 250 for autologous WBC and ZAR4 804 for NPWT in scenario 1, and ZAR3 332 and ZAR6 612 in scenario 2. With healing rates over 4 weeks' treatment duration of 19% for autologous WBC and 10% for NPWT, autologous WBC saved ZAR17 719.93, or 9% more than using NPWT, in scenario 1 and ZAR18 381.47, or 10% more, in scenario 2. At 12 weeks' treatment duration, healing rates for autologous WBC and NPWT were 75% and 43%, respectively. In scenario 1, results indicated a 43% cost difference between the two modalities. Autologous WBC had a total cost saving of ZAR61 874.40 compared with NPWT over a period of 12 weeks. In scenario 2, results indicated a 46% cost difference between the two modalities. Autologous WBC had a total cost saving of ZAR70 454.68 compared with NPWT over a period of 12 weeks. One of the identified social considerations is that NPWT needs a reliable supply of electricity to recharge the pump, while autologous WBC does not. Conclusion. Both modalities are safe and effective in treating hard-to-heal wounds of the lower extremities. Autologous WBC consistently demonstrated better outcomes than NPWT in terms of both healing rate and cost-effectiveness, as well as having some advantages in terms of social considerations in SA.
C1 [Naude, L.] Eloquent Learning Hlth & Fdn Profess Dev, Adv Wound Care, Pretoria, South Africa.
   [Naude, L.] Eloquent Learning Hlth & Fdn Profess Dev, Wound Care, Pretoria, South Africa.
   [Balenda, G.] Tembisa Prov Tertiary Hosp, Johannesburg, South Africa.
   [Lombaard, A.] Eloquent Hlth & Wellness, Pretoria, South Africa.
RP Naude, L (通讯作者)，Eloquent Learning Hlth & Fdn Profess Dev, Adv Wound Care, Pretoria, South Africa.; Naude, L (通讯作者)，Eloquent Learning Hlth & Fdn Profess Dev, Wound Care, Pretoria, South Africa.
EM liezl@eloquent.co.za
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NR 49
TC 2
Z9 3
U1 0
U2 2
PU SA MEDICAL ASSOC
PI PRETORIA
PA BLOCK F CASTLE WALK CORPORATE PARK, NOSSOB STREET, ERASMUSKLOOF EXT3,
   PRETORIA, 0002, SOUTH AFRICA
SN 0256-9574
EI 2078-5135
J9 SAMJ S AFR MED J
JI SAMJ S. Afr. Med. J.
PD OCT
PY 2022
VL 112
IS 10
BP 800
EP 805
DI 10.7196/SAMJ.2022.v112i10.16527
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5M5EM
UT WOS:000871118200007
PM 36472331
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ciprandi, G
   Kjartanason, H
   Grussu, F
   Baldursson, BT
   Frattaroli, J
   Urbani, U
   Zama, M
AF Ciprandi, Guido
   Kjartanason, Hilmar
   Grussu, Francesca
   Baldursson, Baldur T.
   Frattaroli, Jacopo
   Urbani, Urbano
   Zama, Mario
TI Use of acellular intact fish skin grafts in treating acute paediatric
   wounds during the COVID-19 pandemic: a case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE complex wounds; intact fish skin; paediatric complex wounds; skin
   substitutes; wound; wound care; wound dressing; wound healing
ID DERMAL MATRIX; THERAPY
AB Objective: More specific strategies are needed to support children requiring skin grafting. Our goal was to identify procedures that reduce operating times, post-operative complications, pain and length of hospital stay. Patient safety, optimal wound bed support and quick micro-debridement with locoregional anaesthesia were prioritised. Ultimately, a novel acellular fish skin graft (FSG) derived from north Atlantic cod was selected for use.
   Method: We admitted consecutive paediatric patients with various lesions requiring skin grafting for definitive wound closure. All FSGs were applied and bolstered in the operating room following debridement.
   Results: In a cohort of 15 patients, the average age was 8 years and 9 months (4 years 1 month-13 years 5 months). Negative pressure wound therapy (NPWT) was given to 12 patients. Rapid wound healing was observed in all patients, with a wound area coverage of 100% and complete healing in 95% of wounds. Time until engraftment in patients receiving NPWT was reduced by about a half (to an average 12 days) from our standard experience of 21 days. Ten patients received locoregional anaesthesia and were discharged after day surgery. The operating time was <60 minutes, and no complications or allergic reactions were reported. Excellent pliability of the healed wound was achieved in all patients, without signs of itching and scratching in the postoperative period. This case series is the first and largest using FSG to treat paediatric patients with different wound aetiologies. We attribute the rapid transition to acute wound status and the good pliability of the new epidermal-dermal complex to the preserved molecular components of the FSG, including omega-3.
   Conclusion: FSG represents an innovative and sustainable solution for paediatric wound care that results in shorter surgery time and reduced hospital stays, with accelerated wound healing times.
   Declaration of interest: HK and BB are co-founders and current employees of Kerecis Limited. No funding was received for the creation of this manuscript. The authors have no other conflicts of interest to declare.
C1 [Ciprandi, Guido; Grussu, Francesca; Frattaroli, Jacopo; Urbani, Urbano; Zama, Mario] Bambino Gesu Pediat Hosp, Res Inst, Div Plast & Maxillofacial Surg, Rome, Italy.
   [Kjartanason, Hilmar; Baldursson, Baldur T.] Landspitali Univ Hosp, Reykjavik, Iceland.
   [Kjartanason, Hilmar; Baldursson, Baldur T.] Kerecis Ltd, Reykjavik, Iceland.
C3 IRCCS Bambino Gesu; Landspitali National University Hospital
RP Ciprandi, G (通讯作者)，Bambino Gesu Pediat Hosp, Res Inst, Div Plast & Maxillofacial Surg, Rome, Italy.
EM guido.ciprandi@opbg.net
RI Zama, Mario/AAD-6351-2022; frattaroli, jacopo maria/ABC-8342-2021;
   CIPRANDI, GUIDO/AAA-6133-2020; Kjartansson, Hilmar/JYO-5445-2024
OI CIPRANDI, GUIDO/0000-0003-0125-5534; Kjartansson,
   Hilmar/0000-0003-4891-2976
CR Altmanshofer B, 2017, S ADV WOUND CARE FAL
   Badois N, 2019, J WOUND CARE, V28, P624, DOI 10.12968/jowc.2019.28.9.624
   Baldursson BT, 2015, INT J LOW EXTR WOUND, V14, P37, DOI 10.1177/1534734615573661
   Ciprandi G, 2020, APT FERIDAS WOUNDS I
   Clark RAF., 2013, PRINCIPLES TISSUE EN
   Clasen TJ, 2017, Wound Manag, V11, P183
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   Faust SN, 2021, JAMA PEDIATR, V175, P127, DOI 10.1001/jamapediatrics.2020.4582
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   Yang CK, 2016, WOUNDS, V28, P112
NR 29
TC 12
Z9 14
U1 1
U2 4
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2022
VL 31
IS 10
BP 824
EP 831
DI 10.12968/jowc.2022.31.10.824
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 5M7DN
UT WOS:000871258000004
PM 36240798
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Zhao, AH
   Kwok, CHR
   Jansen, SJ
AF Zhao, Adam Hanting
   Kwok, Chi Ho Ricky
   Jansen, Shirley Jane
TI How to Prevent Surgical Site Infection in Vascular Surgery: A Review of
   the Evidence
SO ANNALS OF VASCULAR SURGERY
LA English
DT Review
ID GREAT SAPHENOUS-VEIN; RECONSTRUCTIVE ARTERIAL-SURGERY; RANDOMIZED
   CONTROLLED-TRIAL; NEGATIVE-PRESSURE THERAPY; PREOPERATIVE HAIR REMOVAL;
   LOWER-EXTREMITY BYPASS; WOUND-INFECTION; ANTIBIOTIC-PROPHYLAXIS;
   RISK-FACTORS; ANTIMICROBIAL PROPHYLAXIS
AB Background: This review aims to identify and review the current evidence for preventing postoperative surgical site infections in abdominal aortic aneurysm surgery or infrainguinal arterial surgery.
   Methods: Extended literature review of clinical trials that examined the prevention of postoperative surgical site infections in abdominal aortic aneurysm or infrainguinal arterial surgery. Searches were conducted on Ovid MEDLINE (1950 - 13 March 2020) using key terms for vascular surgery, surgical site infections and specific preventative techniques. Articles were included if they discussed a relationship between a preventative technique and surgical site infections in abdominal aortic aneurysm or infrainguinal arterial surgery. The GRADE guidelines were used to assess the quality of evidence.
   Results: 21 techniques and 81 studies were included. Prophylactic antibiotics and negative pressure wound therapy have a high quality of evidence for the prevention of surgical site infections in abdominal aortic aneurysm or infrainguinal arterial surgery. A moderate quality evidence base was identified for gentamicin containing collagen implant (confined to high surgical site infection risk centers). Currently, there is a low or very low quality of evidence to suggest a reduction in the surgical site infection rate for combination therapy, glycaemic control, Methicillin-resistant Staphylococcus aureus screening and absorbable suture. Evidence suggests no beneficial effect for nutritional supplementation, chlorhexidine bath, hair removal therapy, Staphylococcus aureus nasal eradication, cyanoacrylate microsealant, silver grafts, rifampicin bonded grafts, triclosan coated suture and postoperative wound drains. Endoscopic saphenous vein harvest may reduce surgical site infection rate (very low quality of evidence) but may lower long-term patency. Autologous vein grafts may increase surgical site infections (very low quality of evidence) but may provide better long-term patency rates in above-knee infrainguinal bypass surgery. There was no identified evidence for perioperative normother mia, electrosurgical bipolar vessel sealer or Dermabond and Tegaderm for surgical site infection prevention in vascular surgery.
   Conclusions: Prophylactic antibiotics and postoperative negative pressure wound therapy are effective in the prevention of postoperative surgical site infection in abdominal aortic aneurysm or infrainguinal arterial surgery. There exists a significant risk of bias in the literature for many preventative techniques and further studies are required to investigate the efficacy of gentamicin containing collagen implant, and specific combination therapies.
C1 [Zhao, Adam Hanting; Jansen, Shirley Jane] Univ Western Australia, Sch Med, Fac Hlth & Med Sci, Mailbox Drop Point 509,35 Stirling Hwy, Nedlands, WA 6009, Australia.
   [Zhao, Adam Hanting; Kwok, Chi Ho Ricky; Jansen, Shirley Jane] Sir Charles Gairdner Hosp, Dept Vasc & Endovasc Surg, Nedlands, WA, Australia.
   [Jansen, Shirley Jane] Curtin Univ, Fac Hlth Sci, Curtin Med Sch, Perth, WA, Australia.
   [Jansen, Shirley Jane] Harry Perkins Inst Med Res, Heart & Vasc Res Inst, Nedlands, WA, Australia.
C3 University of Western Australia; Sir Charles Gairdner Hospital;
   University of Western Australia; Curtin University; Harry Perkins
   Institute of Medical Research
RP Zhao, AH (通讯作者)，Univ Western Australia, Sch Med, Fac Hlth & Med Sci, Mailbox Drop Point 509,35 Stirling Hwy, Nedlands, WA 6009, Australia.; Zhao, AH (通讯作者)，Sir Charles Gairdner Hosp, QEII Med Ctr, Dept Vasc & Endovasc Surg, Level 4,A Block, Nedlands, WA 6009, Australia.
EM adam.zhao@health.wa.gov.au
RI /AGR-4157-2022; Jansen, Shirley/AAU-3889-2021
OI Zhao, Adam/0000-0002-4764-2508; Jansen, Shirley/0000-0001-7781-4748
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NR 116
TC 10
Z9 12
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD JAN
PY 2022
VL 78
BP 336
EP 361
DI 10.1016/j.avsg.2021.06.045
PG 26
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 5N7CY
UT WOS:000871946700040
PM 34543711
DA 2026-07-24
ER
PT J
AU Hamaguchi, R
   Wearda, TL
   Volk, AS
   Kramer, KM
   Kimball, AB
   Chaffin, AE
   Orgill, DP
AF Hamaguchi, Ryoko
   Wearda, Taylor L.
   Volk, Angela S.
   Kramer, Kimberly M.
   Kimball, Alexa B.
   Chaffin, Abigail E.
   Orgill, Dennis P.
TI Surgical Management of Hidradenitis Suppurativa: A Two-Center
   Retrospective Study
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID GLUTEAL; RECONSTRUCTION; EXPERIENCE; OUTCOMES
AB Background: Hidradenitis suppurativa is a chronic inflammatory condition that presents a challenging reconstructive problem for plastic surgeons.
   Methods: The authors performed a retrospective chart review of hidradenitis suppurativa patients managed with surgical excision between 2005 and 2020 at Brigham and Women's Hospital and Tulane University Medical Center. Operative cases associated with the same hospitalization were organized into treatment episodes and assessed for patient demographics, operative techniques, and outcomes.
   Results: A total of 181 patients, 435 cases and 316 treatment episodes (Brigham and Women's Hospital, n = 269; Tulane University Medical Center, n = 47), were identified across two diverse institutions. Their respective series showed comparable patient demographics, and 94 percent of the combined episodes achieved wound closure and healing during the study period. Several techniques of closure were identified, including immediate closure and site-specific methods, such as an expedited staged closure using internal negative-pressure wound therapy as a temporary bridge, "recycled" skin grafting, and repurposing iodoform wicks as an adjunct wound healing therapy to immediate closure.
   Conclusions: This large multi-institutional retrospective chart review on the plastic surgical management of hidradenitis suppurativa demonstrates that surgery is an effective therapy for hidradenitis suppurativa and captures a diversity of site-specific techniques that may serve as a foundation for future prospective studies and evidence-based guidelines for the use of various techniques to optimize patients' surgical outcomes. (Plast. Reconstr. Surg. 150: 1115, 2022.)
   CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.
C1 Harvard Med Sch, Boston, MA 02115 USA.
   Tulane Univ, Div Plast & Reconstruct Surg, Sch Med, New Orleans, LA 70118 USA.
   [Orgill, Dennis P.] Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   Beth Israel Deaconess Med Ctr, Dept Dermatol, Boston, MA 02215 USA.
C3 Harvard University; Harvard Medical School; Tulane University; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard University Medical Affiliates;
   Beth Israel Deaconess Medical Center
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@bwh.harvard.edu
RI Orgill, Dennis/H-7596-2019
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NR 20
TC 7
Z9 9
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2022
VL 150
IS 5
BP 1115
EP 1127
DI 10.1097/PRS.0000000000009658
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5O9AA
UT WOS:000872755400053
PM 36288254
DA 2026-07-24
ER
PT J
AU Struebing, F
   Xiong, LY
   Bigdeli, AK
   Diehm, Y
   Kneser, U
   Hirche, C
   Gazyakan, E
AF Struebing, Felix
   Xiong, Lingyun
   Bigdeli, Amir K.
   Diehm, Yannick
   Kneser, Ulrich
   Hirche, Christoph
   Gazyakan, Emre
TI Microsurgical Strategies after Free Flap Failure in Soft Tissue
   Reconstruction of the Lower Extremity: A 17-Year Single-Center
   Experience
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE lower extremity; free flap; flap failure; secondary free flap; tertiary
   free flap; orthoplastic; limb salvage
ID FAILED FREE FLAPS; LIMB INJURIES; OUTCOMES; SALVAGE; DEFECTS;
   METAANALYSIS; AMPUTATION; CONSENSUS; TRAUMA; MULTICENTER
AB Background: There is no clear consensus on the optimal surgical strategy for providing safe coverage in salvage free flap surgery after total free flap failure. Methods: A retrospective study was conducted to evaluate patients with total failure of the primary free flap in lower extremity reconstruction between 2000 and 2017. Results: In a cohort of 1.016 patients, we identified 43 cases of total flap failure (4.2%). A total of 30 patients received a salvage free flap with a success rate of 83.3% (25/30). One patient received a secondary salvage free flap. Overall limb salvage after primary free flap loss was 83.7% (36/43). Conclusions: Microsurgical management of free flap loss in the lower extremity is challenging and requires a decisive re-evaluation of risk factors and alternative strategies. This should include reconsidering the flap choice with a tendency towards traditional and safe workhorse flaps, a low-threshold switch to different recipient vessels, including arteriovenous (AV) loops, bypasses (especially in case of venous insufficiency) and back-up procedures, such as negative pressure wound therapy or dermal regeneration templates with skin grafting in cases of lower demand and critically ill patients. We derived one suggestion from our previous practice: replacing perforator flaps with axial pattern flaps ("safe workhorses").
C1 [Struebing, Felix; Xiong, Lingyun; Bigdeli, Amir K.; Diehm, Yannick; Kneser, Ulrich; Hirche, Christoph; Gazyakan, Emre] Heidelberg Univ, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg, D-67071 Ludwigshafen, Germany.
   [Xiong, Lingyun] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Plast Surg, Wuhan 430022, Peoples R China.
   [Hirche, Christoph] Goethe Univ Frankfurt, Hand Trauma & Replantat Ctr, BG Trauma Ctr Frankfurt Main, Dept Plast Hand & Reconstruct Microsurg,Affiliate, D-60389 Frankfurt, Germany.
C3 Ruprecht Karls University Heidelberg; Huazhong University of Science &
   Technology; Goethe University Frankfurt
RP Gazyakan, E (通讯作者)，Heidelberg Univ, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg, D-67071 Ludwigshafen, Germany.
EM emre.gazyakan@bgu-ludwigshafen.de
RI ; Gazyakan, Emre/HLW-5585-2023
OI Hirche, Christoph/0000-0001-6112-8671; Kneser,
   Ulrich/0000-0002-3402-2860; Gazyakan, Emre/0000-0003-2826-2793; Bigdeli,
   Amir Khosrow/0000-0001-8852-5132
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NR 46
TC 10
Z9 12
U1 1
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD OCT
PY 2022
VL 12
IS 10
AR 1563
DI 10.3390/jpm12101563
PG 16
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA 5P0NC
UT WOS:000872857500001
PM 36294702
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Altomare, M
   Benuzzi, L
   Molteni, M
   Virdis, F
   Spota, A
   Cioffi, SPB
   Reitano, E
   Renzi, F
   Chiara, O
   Sesana, G
   Cimbanassi, S
AF Altomare, Michele
   Benuzzi, Laura
   Molteni, Mattia
   Virdis, Francesco
   Spota, Andrea
   Cioffi, Stefano Piero Bernardo
   Reitano, Elisa
   Renzi, Federica
   Chiara, Osvaldo
   Sesana, Giovanni
   Cimbanassi, Stefania
TI Negative Pressure Wound Therapy for the Treatment of Fournier's
   Gangrene: A Rare Case with Rectal Fistula and Systematic Review of the
   Literature
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Review
DE case report; Negative Pressure Wound Therapy (NPWT); Fournier's
   gangrene; rectal fistula; hyperbaric oxygen therapy; surgical technique
ID VACUUM-ASSISTED CLOSURE; NECROTIZING FASCIITIS; MANAGEMENT; EXPERIENCE
AB Fournier's gangrene (FG) is a Necrotizing Soft Tissue Infection (NSTI) of the perineal region characterized by high morbidity and mortality even if appropriately treated. The main treatment strategies are surgical debridement, broad-spectrum antibiotics, hyperbaric oxygen therapy, NPWT (Negative Pressure Wound Therapy), and plastic surgery reconstruction. We present the case of a 50-year-old woman with an NSTI of the abdomen, pelvis, and perineal region associated with a rectal fistula referred to our department. After surgical debridement and a diverting blow-out colostomy, an NPWT system composed of two sponges connected by a bridge through a rectal fistula was performed. Our target was to obtain healing in a lateral-to-medial direction instead of depth-to-surface to prevent the enlargement of the rectal fistula, promoting granulation tissue growth towards the rectum. This eso-endo-NPWT technique allowed for the primary suture of the perineal wounds bilaterally, simultaneously treating the rectal fistula and the perineum lesions. A systematic review of the literature underlines the spreading of NPWT and its effects.
C1 [Altomare, Michele] Sapienza Univ Rome, Dept Surg Sci, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
   [Altomare, Michele; Virdis, Francesco; Spota, Andrea; Cioffi, Stefano Piero Bernardo; Renzi, Federica; Chiara, Osvaldo; Cimbanassi, Stefania] ASST Niguarda, Gen Surg & Trauma Team, Piazza Osped Maggiore 3, I-20162 Milan, Italy.
   [Benuzzi, Laura] Univ Milan, Gen Surg Residency Program, Via Festa Perdono 7, I-20122 Milan, Italy.
   [Molteni, Mattia] Univ Vita Salute, San Raffaele Sci Inst HSR, Dept Surg, I-20132 Milan, Italy.
   [Reitano, Elisa] Osped Maggiore Carita Novara, I-28100 Novara, Italy.
   [Chiara, Osvaldo; Cimbanassi, Stefania] Univ Milan, Dept Med Surg Physiopathol & Transplantat, Festa Perdono 7, I-20122 Milan, Italy.
   [Sesana, Giovanni] ASST Niguarda, Tissue Bank & Tissue Therapy, Piazza Osped Maggiore 3, I-20162 Milan, Italy.
C3 Sapienza University Rome; Ospedale Niguarda Ca' Granda; University of
   Milan; Vita-Salute San Raffaele University; Azienda Ospedaliera Maggiore
   della Carita di Novara; University of Milan; Ospedale Niguarda Ca'
   Granda
RP Altomare, M (通讯作者)，Sapienza Univ Rome, Dept Surg Sci, Piazzale Aldo Moro 5, I-00185 Rome, Italy.; Altomare, M (通讯作者)，ASST Niguarda, Gen Surg & Trauma Team, Piazza Osped Maggiore 3, I-20162 Milan, Italy.
EM michele.altomare@uniroma1.it
RI Spota, Andrea/LGE-4438-2024; cimbanassi, stefania/HKF-0985-2023; Cioffi,
   Stefano Piero Bernardo/AAA-2281-2020; chiara, osvaldo/R-6151-2018;
   Altomare, Michele/AAE-7981-2022; Reitano, Elisa/AAB-9182-2021; Palmieri,
   Francesco/KYO-7188-2024
OI Spota, Andrea/0000-0002-7058-5089; cimbanassi,
   stefania/0000-0002-7874-2640; Cioffi, Stefano Piero
   Bernardo/0000-0002-5453-8901; chiara, osvaldo/0000-0003-2409-2109;
   Molteni, Mattia/0000-0003-1471-439X; Altomare,
   Michele/0000-0002-3879-2678; Reitano, Elisa/0000-0002-4286-8866; 
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NR 40
TC 6
Z9 10
U1 0
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD OCT
PY 2022
VL 12
IS 10
AR 1695
DI 10.3390/jpm12101695
PG 15
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA 5P3BD
UT WOS:000873029200001
PM 36294834
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wu, MF
   Matar, DY
   Yu, Z
   Chen, ZY
   Knoedler, S
   Ng, B
   Darwish, OA
   Sohrabi, S
   Friedman, L
   Haug, V
   Murphy, GF
   Rinkevich, Y
   Orgill, DP
   Panayi, AC
AF Wu, Mengfan
   Matar, Dany Y.
   Yu, Zhen
   Chen, Ziyu
   Knoedler, Samuel
   Ng, Brian
   Darwish, Oliver A.
   Sohrabi, Sadaf
   Friedman, Leigh
   Haug, Valentin
   Murphy, George F.
   Rinkevich, Yuval
   Orgill, Dennis P.
   Panayi, Adriana C.
TI Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing
SO PHARMACEUTICS
LA English
DT Article
DE wound healing; fibrosis; scarring; NPWT; mechanotransduction; YAP;
   tissue regeneration; caspase3
ID NEGATIVE-PRESSURE THERAPY; CELL-PROLIFERATION; HYPERTROPHIC SCARS;
   SURGICAL WOUNDS; SKIN; TRANSITION; MANAGEMENT; EXPRESSION; PROTEIN;
   APOPTOSIS
AB Scarring is associated with significant morbidity. The mechanical signaling factor yes-associated protein (YAP) has been linked to Engrailed-1 (En1)-lineage positive fibroblasts (EPFs), a pro-scarring fibroblast lineage, establishing a connection between mechanotransduction and fibrosis. In this study, we investigate the impact of micromechanical forces exerted through negative pressure wound therapy (NPWT) on the pathophysiology of fibrosis. Full-thickness excisional dorsal skin wounds were created on diabetic (db/db) mice which were treated with occlusive covering (control) or NPWT (continuous, -125 mmHg, 7 days; NPWT). Analysis was performed on tissue harvested 10 days after wounding. NPWT was associated with increased YAP (p = 0.04) but decreased En1 (p = 0.0001) and CD26 (p < 0.0001). The pro-fibrotic factors Vimentin (p = 0.04), alpha-SMA (p = 0.04) and HSP47 (p = 0.0008) were decreased with NPWT. Fibronectin was higher (p = 0.01) and collagen deposition lower in the NPWT group (p = 0.02). NPWT increased cellular proliferation (p = 0.002) and decreased apoptosis (p = 0.03). Western blotting demonstrated increased YAP (p = 0.02) and RhoA (p = 0.03) and decreased Caspase-3 (p = 0.03) with NPWT. NPWT uncouples YAP from EPF activation, through downregulation of Caspace-3, a pro-apoptotic factor linked to keloid formation. Mechanotransduction decreases multiple pro-fibrotic factors. Through this multifactorial process, NPWT significantly decreases fibrosis and offers promising potential as a mode to improve scar appearance.
C1 [Wu, Mengfan] Peking Univ Shenzhen Hosp, Dept Plast Surg, Shenzhen 518036, Peoples R China.
   [Wu, Mengfan; Matar, Dany Y.; Chen, Ziyu; Knoedler, Samuel; Ng, Brian; Darwish, Oliver A.; Friedman, Leigh; Haug, Valentin; Orgill, Dennis P.; Panayi, Adriana C.] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA 02115 USA.
   [Matar, Dany Y.] Washington Univ, Sch Med, St Louis, MO 63110 USA.
   [Yu, Zhen] Jinan Univ, Shenzhen Eye Hosp, Dept Ophthalmol, Shenzhen Key Ophthalm Lab, Shenzhen 518040, Peoples R China.
   [Yu, Zhen] Harvard Med Sch, Massachusetts Eye & Ear Infirm, Dept Ophthalmol, Angiogenesis Lab, Boston, MA 02114 USA.
   [Knoedler, Samuel] Tech Univ Munich, Dept Plast Surg & Hand Surg, Klinikum Rechts Isar, D-81675 Munich, Germany.
   [Ng, Brian] St Louis Univ, Sch Med, St Louis, MO 63104 USA.
   [Darwish, Oliver A.] Calif Northstate Univ, Sch Med, Elk Grove, CA 95757 USA.
   [Sohrabi, Sadaf; Murphy, George F.] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Div Dermatopathol, Boston, MA 02115 USA.
   [Friedman, Leigh] Lehigh Univ, Dept Med, Bethlehem, PA 18015 USA.
   [Friedman, Leigh] Drexel Univ, Sch Med, Philadelphia, PA 19129 USA.
   [Haug, Valentin; Panayi, Adriana C.] Heidelberg Univ, Burn Ctr, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg,Microsurg, D-67071 Ludwigshafen, Germany.
   [Rinkevich, Yuval] Helmholtz Zentrum Munchen, Sch Med, Inst Regenerat Biol & Med, D-81377 Munich, Germany.
C3 Peking University; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard Medical School;
   Washington University (WUSTL); Jinan University; Shenzhen Eye Hospital;
   Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts Eye & Ear Infirmary; Technical University of
   Munich; Saint Louis University; Harvard University; Harvard Medical
   School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Lehigh University; Drexel University; Ruprecht Karls
   University Heidelberg; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health
RP Panayi, AC (通讯作者)，Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA 02115 USA.; Panayi, AC (通讯作者)，Heidelberg Univ, Burn Ctr, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg,Microsurg, D-67071 Ludwigshafen, Germany.
EM a.panayi@cantab.net
RI ; Haug, Valentin/ADF-7566-2022; Knoedler, Samuel Alfons/IZQ-4210-2023;
   Orgill, Dennis/H-7596-2019; Panayi, Adriana/HHT-0513-2022
OI Chen, Ziyu/0000-0001-5562-7554; Knoedler, Samuel
   Alfons/0000-0001-5798-8003; Matar, Dany/0000-0001-7108-0413; Friedman,
   Leigh/0000-0002-4047-7896; Wu, Mengfan/0000-0003-2646-3372; Panayi,
   Adriana/0000-0003-4053-9855; Yu, Zhen/0000-0003-3456-3584
FU Gillian Reny Stepping Strong Center for Trauma Innovation; 3M*KCI
   (Kinetic Concepts Inc.); UK-US Fulbright commission; NIH [5 T35
   HL11084]; Natural Science Foundation from Shenzhen Science and
   Technology Innovation Commission [20210319172905002]; Shenzhen Key
   Medical Discipline Construction Fund [SZXK026]; European Research
   Council [819933]; LEO Foundation [LF-OC-21-000835]; European Foundation
   for the Study of Diabetes (EFSD) Anniversary Fund Programme; European
   Research Council (ERC) [819933] Funding Source: European Research
   Council (ERC)
FX This work was funded by The Gillian Reny Stepping Strong Center for
   Trauma Innovation and 3M*KCI (Kinetic Concepts Inc.). S.S. was funded by
   the UK-US Fulbright commission with an All Disciplines Award. L.F. was
   funded by the NIH 5 T35 HL11084 fellowship award. M.W. was supported by
   the Natural Science Foundation from Shenzhen Science and Technology
   Innovation Commission(20210319172905002) and the Shenzhen Key Medical
   Discipline Construction Fund (No.SZXK026). Y.R. was supported by the
   European Research Council Consolidator Grant (ERC-CoG 819933), the LEO
   Foundation (LF-OC-21-000835) and the European Foundation for the Study
   of Diabetes (EFSD) Anniversary Fund Programme.
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NR 48
TC 15
Z9 17
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD OCT
PY 2022
VL 14
IS 10
AR 2125
DI 10.3390/pharmaceutics14102125
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5Q4OF
UT WOS:000873812500001
PM 36297560
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Svensson-Björk, R
   Hasselmann, J
   Asciutto, G
   Zarrouk, M
   Björk, J
   Bilos, L
   Pirouzram, A
   Acosta, S
AF Svensson-Bjork, Robert
   Hasselmann, Julien
   Asciutto, Giuseppe
   Zarrouk, Moncef
   Bjork, Jonas
   Bilos, Linda
   Pirouzram, Artai
   Acosta, Stefan
TI Negative Pressure Wound Therapy for the Prevention of Surgical Site
   Infections Using Fascia Closure After EVAR-A Randomized Trial
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID SUTURE TECHNIQUE; CLINICAL-TRIALS; EDITORS CHOICE; METAANALYSIS;
   RECONSTRUCTION; COMPLICATIONS; DEVICES; ACCESS
AB Background Surgical site infections (SSI) in the groin after vascular surgery are common. The aim of the study was to evaluate the effect of negative pressure wound therapy (NPWT) on SSI incidence when applied on closed inguinal incisions after endovascular aneurysm repair (EVAR). Methods A multicenter randomized controlled trial (RCT). Between November 2013 and December 2020, 377 incisions (336 bilateral and 41 unilateral) from elective EVAR procedures with the primary intent of fascia closure were randomized and included, receiving either NPWT or a standard dressing. In bilateral incisions, each incision randomly received the opposite dressing of the other side, thereby becoming each other's control. The primary endpoint was SSI incidence at 90 days postoperatively, analyzed on an intention-to-treat basis. Uni and bilaterally operated incisions were analyzed separately, and their respective p-values combined using Fisher's method for combining P-values. Study protocol (NCT01913132). Results The SSI incidence at 90 days postoperatively in bilateral incisions was 1.8% (n = 3/168) in the NPWT and 4.8% (n = 8/168) in the standard dressing group, and in unilateral incisions 13.3% (n = 2/15) and 11.5% (n = 3/26), respectively (combined p = 0.49). In all SSIs, bacteria were isolated from incisional wound cultures. No additional SSIs were diagnosed between 90 days and 1 year follow-up. Conclusions No evidence of difference in SSI incidence was seen in these low-risk inguinal incisions when comparing NPWT with standard dressings after EVAR with the primary intent of fascia closure.
C1 [Svensson-Bjork, Robert; Hasselmann, Julien; Asciutto, Giuseppe; Zarrouk, Moncef; Acosta, Stefan] Lund Univ, Dept Clin Sci, Vasc Dis Res Unit, Ruth Lundskogs Gata 10, S-20502 Malmo, Sweden.
   [Hasselmann, Julien; Zarrouk, Moncef; Acosta, Stefan] Skane Univ Hosp, Vasc Ctr, Malmo, Sweden.
   [Asciutto, Giuseppe] Uppsala Univ Hosp, Dept Vasc Surg, Uppsala, Sweden.
   [Bjork, Jonas] Lund Univ, Div Occupat & Environm Med, Lund, Sweden.
   [Bjork, Jonas] Lund Univ, Forum South, Clin Studies Sweden, Lund, Sweden.
   [Bilos, Linda; Pirouzram, Artai] Linkoping Univ Hosp, Dept Cardiothorac & Vasc Surg, Vasc Surg Unit, Linkoping, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Uppsala
   University; Uppsala University Hospital; Lund University; Lund
   University; Linkoping University
RP Svensson-Björk, R (通讯作者)，Lund Univ, Dept Clin Sci, Vasc Dis Res Unit, Ruth Lundskogs Gata 10, S-20502 Malmo, Sweden.
EM Robert.Svensson_Bjork@med.lu
RI Acosta, Stefan/JAX-3225-2023; Björk, Jonas/AFS-4819-2022
OI Acosta, Stefan/0000-0002-3225-0798; Björk, Jonas/0000-0003-1883-2000
FU Lund University; Swedish medical research council [2019-00435]; Hulda
   Almroth Foundation; Skane University hospital, Region Skane; Swedish
   government; Swedish Research Council [2019-00435] Funding Source:
   Swedish Research Council
FX Open access funding provided by Lund University. Research funds were
   received from the Swedish medical research council (2019-00435), the
   Hulda Almroth Foundation, Skane University hospital, Region Skane, the
   Swedish government under the ALF agreement and Smith & Nephew (2013)
   which also provided 100 PICOTM dressings. The funding sources were not
   involved in study design, analysis, interpretation, writing or
   submission of the manuscript.
CR Antoniou GA, 2021, EUR J VASC ENDOVASC, V61, P383, DOI 10.1016/j.ejvs.2020.11.008
   Antoniou GA, 2019, J VASC SURG, V70, P1700, DOI 10.1016/j.jvs.2019.01.083
   Bosanquet D, 2021, INT WOUND J, V18, P164, DOI 10.1111/iwj.13508
   Centers for disease control and prevention, 2022, JAMA SURG
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NR 23
TC 13
Z9 15
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD DEC
PY 2022
VL 46
IS 12
BP 3111
EP 3120
DI 10.1007/s00268-022-06740-5
EA OCT 2022
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5Y1GG
UT WOS:000873936200002
PM 36241857
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Frenda, G
   Baker, L
   Zhang, YM
   Nessim, C
AF Frenda, Giuseppe
   Baker, Laura
   Zhang, Yimeng
   Nessim, Carolyn
TI Role of a skin bridge incision and prophylactic incisional
   negative-pressure wound therapy in the prevention of surgical site
   infection after inguinal lymph node dissection
SO CANADIAN JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Society-for-Surgical-Oncology (SSO) /
   International Conference on Surgical Cancer Care
CY AUG 17-18, 2020
CL ELECTR NETWORK
SP Soc Surg Oncol
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; MELANOMA; COMPLICATIONS;
   MORBIDITY; GUIDELINE; OUTCOMES; MODEL; STATE
AB Background:Modification of the surgical technique to a 2-incision technique with skin bridge from the traditional lazy S (LS) incision, as well as use of prophylactic incisional negative-pressure wound therapy (iNPWT), are theorized to reduce the risk of surgical site infection (SSI) after inguinal lymph node dissection (ILND). We sought to investigate the role of a perioperative ILND bundle on adverse events after ILND and lymph node harvest. Methods:We performed a retrospective review of patients who underwent ILND before and after implementation of the ILND bundle (September 2016) at 1 centre in southeastern Ontario between 2013 and 2018. The ILND bundle included a skin bridge incision, running subcuticular skin closure and NPWT. Previously, an LS incision was used, with stapled skin closure and conventional dressing. Development of SSI was the primary outcome, and dehiscence and seroma and hematoma formation were secondary outcomes. We estimated the associations using multivariable logistic regression. Results:Thirty-four ILNDs in 33 patients were included, 15 in the LS incision group and 19 in the perioperative bundle group. The baseline demographic characteristics of the 2 groups were similar. The perioperative bundle was associated with a reduction in the SSI rate (11 [73%] v. 6 [32%], p = 0.02) and elimination of wound dehiscence (0 [0%] v. 5 [33%], p = 0.006). On multivariable logistic regression, it was associated with a 5.9-fold reduction in the SSI rate (odds ratio 0.17, 95% confidence interval 0.03-0.74). Conclusion:The results suggest a decrease in SSI rates with use of a perioperative bundle compared to the LS incision and a standard dressing. Randomized controlled trials are required to better understand the associations among the skin bridge incision, iNPWT and SSI.
C1 [Frenda, Giuseppe] McGill Univ, Div Gen Surg, Montreal, PQ, Canada.
   [Baker, Laura; Zhang, Yimeng; Nessim, Carolyn] Univ Ottawa, Ottawa Hosp Res Inst, Div Gen Surg, Ottawa, ON, Canada.
   [Nessim, Carolyn] Univ Ottawa, Ottawa Hosp, Canc Therapeut Program, OHRI Surg Oncol, Room CCW 1617d,POB 202,501 Smyth Rd, Ottawa, ON K1H 8L6, Canada.
C3 McGill University; University of Ottawa; Ottawa Hospital Research
   Institute; University of Ottawa; Ottawa Hospital Research Institute
RP Nessim, C (通讯作者)，Univ Ottawa, Ottawa Hosp, Canc Therapeut Program, OHRI Surg Oncol, Room CCW 1617d,POB 202,501 Smyth Rd, Ottawa, ON K1H 8L6, Canada.
EM cnessim@toh.ca
RI Nessim, Carolyn/AAH-8293-2019
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NR 37
TC 1
Z9 1
U1 0
U2 5
PU CMA-CANADIAN MEDICAL ASSOC
PI OTTAWA
PA 1867 ALTA VISTA DR, OTTAWA, ONTARIO K1G 5W8, CANADA
SN 0008-428X
EI 1488-2310
J9 CAN J SURG
JI Can. J. Surg.
PD OCT 20
PY 2022
VL 65
IS 5
BP E688
EP E694
DI 10.1503/cjs.005621
EA DEC 2022
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 5R5SN
UT WOS:000874570300001
PM 36265898
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mo, JM
   Huang, YJ
   Wang, Q
   Zhong, H
   Zhai, ZW
   Nong, YC
   Yan, XD
   Huang, XL
   Huang, JH
   Yang, SP
   Sun, JX
   Han, JX
   Zhou, X
   Lu, WS
AF Mo, Jianming
   Huang, Yuanjing
   Wang, Qiu
   Zhong, Hua
   Zhai, Zhenwei
   Nong, Yuechou
   Yan, Xiaodong
   Huang, Xiulu
   Huang, Jianhao
   Yang, Suping
   Sun, Jingxia
   Han, Jiaxia
   Zhou, Xing
   Lu, Wensheng
TI Autologous wound margin point columnar full-thickness skin grafting
   combined with negative pressure wound therapy improves wound healing in
   refractory diabetic foot ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE autologous full-thickness skin graft; diabetic lower extremity ulcers;
   negative pressure wound therapy; refractory wound
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY ULCERS; BLOOD-FLOW;
   PROLIFERATION; COMPLICATIONS; MELLITUS; DISEASE; IMPACT; CELLS
AB Diabetic lower extremity ulcers (DLEUs) are a severe complication of diabetes mellitus (DM) and are difficult to heal. This study aimed to explore the efficacy of autologous point columnar full-thickness skin graft taken from the ulcer wound margin combined with negative pressure wound therapy (NPWT) in refractory DLEUs. This is a prospective cohort study. A total of 40 inpatients with refractory DLEUs were recruited in the Diabetes Foot Center of Guangxi Zhuang Autonomous Region People's Hospital from October 2019 to November 2021. According to the doctors' professional suggestions and the patients' personal wishes, these enrolled patients were divided into two groups based on different topical wound management: the graft group (n = 18) and the conventional wound therapeutic (CWT) group (n = 22). The efficacy evaluations included the time to complete re-epithelialization of the wound and healing speed within 14 days of graft treatment or after 14 days of graft treatment in the two groups. Before the treatment, the graft group had a significantly larger ulcer area than the CWT group [27.22 (15.28, 46.59) versus 10.92 (7.00, 24.93) cm(2), P < .01]. However, the time to complete wound re-epithelialization in the graft group was shorter than in the CWT group [58.22 +/- 30.60 versus 86.09 +/- 49.54 d, P < .05]. Meanwhile, the healing speed in graft group was markedly faster than in CWT group, whether within 14 days [0.60 (0.40, 0.92) versus 0.16 (0.07, 0.34) cm(2)/d, P < .01] or after 14 days of graft treatment [0.57 (0.45, 0.91) versus 0.13 (0.08, 0.27) cm(2)/d, P < .01]. However, the total treatment cost in the graft group was lower than in the CWT group [419.59 +/- 137.20 versus 663.97 +/- 497.02 $, P < .05]. The novel treatment modality of autologous full-thickness skin graft taken from the ulcer wound margin combined with NPWT has hereby proposed for the first time, and is a safe, effective, and reliable method with a good performance-to-cost ratio to promote wound healing and shorten the healing time for DLEUs.
C1 [Mo, Jianming] Jinan Univ, Dept Endocrinol & Metab, Guangzhou, Peoples R China.
   [Mo, Jianming; Wang, Qiu; Zhong, Hua; Zhai, Zhenwei; Nong, Yuechou; Yan, Xiaodong; Huang, Xiulu; Huang, Jianhao; Sun, Jingxia; Han, Jiaxia; Zhou, Xing; Lu, Wensheng] Guangxi Acad Med Sci, Dept Endocrinol & Metab, Nanning 530021, Guangxi, Peoples R China.
   [Mo, Jianming; Huang, Yuanjing; Wang, Qiu; Zhong, Hua; Zhai, Zhenwei; Nong, Yuechou; Yan, Xiaodong; Huang, Xiulu; Huang, Jianhao; Yang, Suping; Sun, Jingxia; Han, Jiaxia; Zhou, Xing; Lu, Wensheng] Peoples Hosp Guangxi Zhuang Autonomous Reg, Nanning 530021, Guangxi, Peoples R China.
   [Huang, Yuanjing; Yang, Suping] Guangxi Acad Med Sci, Hlth Management Ctr, Nanning, Guangxi, Peoples R China.
C3 Jinan University
RP Lu, WS (通讯作者)，Guangxi Acad Med Sci, Dept Endocrinol & Metab, Nanning 530021, Guangxi, Peoples R China.; Lu, WS (通讯作者)，Peoples Hosp Guangxi Zhuang Autonomous Reg, Nanning 530021, Guangxi, Peoples R China.
EM lws2613676@sohu.com
RI Wang, Rundong/LTY-8296-2024; Yan, Xiaodong/KFO-2574-2024; lu,
   wensheng/AAW-7161-2021; lu, wensheng/AAW-7161-2021
OI lu, wensheng/0000-0003-4179-1171; lu, wensheng/0000-0002-0212-3624
FU Guangxi Medical and Health Appropriate Technology Research and
   Development Project [S201422-01]; Natural Science Foundation of China
   [82160052, 81560044, 30860113]; Shanxi Health Research Project [2019165]
FX Guangxi Medical and Health Appropriate Technology Research and
   Development Project, Grant/Award Number: S201422-01; Natural Science
   Foundation of China, Grant/Award Numbers: 82160052, 81560044, 30860113;
   Shanxi Health Research Project, Grant/Award Number: 2019165
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NR 53
TC 9
Z9 11
U1 1
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2023
VL 20
IS 5
BP 1506
EP 1516
DI 10.1111/iwj.14005
EA OCT 2022
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA D5KM3
UT WOS:000875308400001
PM 36307147
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Khan, SA
   Choudry, U
   Salim, A
   Nathani, KR
   Enam, SA
   Shehzad, N
AF Khan, Saad Akhtar
   Choudry, Usama
   Salim, Adnan
   Nathani, Karim Rizwan
   Enam, Syed Ather
   Shehzad, Noman
TI Current Management Trends for Surgical Site Infection After Posterior
   Lumbar Spinal Instrumentation: A Systematic Review
SO WORLD NEUROSURGERY
LA English
DT Review
DE Lumbar fusion; Surgical site infection; Spinal fusion; Spinal implants
ID THERAPY; FUSION; WOUNDS
AB OBJECTIVE: The objective of this systematic review is to determine the fate of spinal implants when patients develop postoperative wound infection after posterior instrumental fusion in a degenerative spine.
   METHODS: A systematic review of the English-language literature (published between January 2001 and July 2020) was undertaken to identify articles documenting the management strategy for surgical site infections (SSIs) after posterior lumbar spinal fusion. Studies on pedicle screw fixation after trauma, immunocompromised, metastatic spine disease, and combined anterior/posterior approach were excluded. Two independent reviewers assessed the level of evidence quality using the criteria set by the North American Spine Society, and disagreements were resolved by consensus.
   RESULTS: Of the 3071 citations identified, 49 met the criteria to undergo full-text review. Outcomes after SSIs were studied from a combined pool of 1150 patients who had undergone instrumental spinal fusion. The collected data showed that 456 patients (39.97%) had undergone spinal implant removal after SSI while 694 patients (60.03%) had their implants retained until the resolution of SSI. There was an absolute risk reduction (ARR) of 29% (-0.292) and a relative risk reduction (RRR) of 50.3% (-0.503) of implant removal if the patient underwent wound debridement following SSI. The number needed to treat (NNT) for wound debridement was calculated at 3.31 from our pooled cohort. The ARR in implant removal following vacuum-assisted closure (VAC) therapy was 16.6% and RRR was noted at 40.4%. This led to a high value of NNT at 6.0 patients. There was an ARR of 33.5% and a RRR of 70.7% was estimated in patients undergoing continuous irrigation.
   CONCLUSIONS: Our review of the literature suggests that surgeons prefer early wound debridement with or without negative pressure wound therapy under antimicrobial coverage for eradication of SSI after posterior lumbar spinal fusion. Implant removal is generally reserved for cases refractory to the other treatment modalities.
C1 [Khan, Saad Akhtar] Liaquat Natl Hosp, Dept Neurosurg, Karachi, Pakistan.
   [Choudry, Usama; Salim, Adnan; Nathani, Karim Rizwan; Enam, Syed Ather] Aga Khan Univ Hosp, Dept Neurosurg, Karachi, Pakistan.
   [Shehzad, Noman] Yorkshire & Humber Deanery, Dept Surg, York, England.
C3 Aga Khan University
RP Khan, SA (通讯作者)，Liaquat Natl Hosp, Dept Neurosurg, Karachi, Pakistan.
EM drsaadkhan84@gmail.com
RI ; Salim, Adnan/AAO-9806-2020
OI Nathani, Karim/0000-0003-4134-7011; Salim, Adnan/0000-0003-4185-673X
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NR 34
TC 9
Z9 12
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD AUG
PY 2022
VL 164
BP 374
EP 380
DI 10.1016/j.wneu.2022.05.138
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 5V3IE
UT WOS:000877125800009
PM 35671992
DA 2026-07-24
ER
PT J
AU Zhong, WD
   Hu, G
   Feng, ZH
   Shen, WD
   Shao, GY
AF Zhong, Wei-dong
   Hu, Gen
   Feng, Zhi-hua
   Shen, Wei-dong
   Shao, Guo-yi
TI Endoluminal Vacuum-Assisted Closure Therapy for Upper Gastrointestinal
   Leak, Perforation, and Fistula: A Case Series and Literature Review
SO DIGESTIVE DISEASES
LA English
DT Review
DE Endoluminal vacuum-assisted closure; Gastrointestinal fistula;
   Esophageal ruptures
ID MANAGEMENT; STENT
AB Background: With the increasing incidence of upper digestive tract tumors, more upper digestive tract surgeries are performed each year, and surgeons have difficulty in the postoperative management of gastrointestinal anastomotic fistula. The use of a new minimally invasive technique, endoluminal vacuum-assisted closure (E-VAC), has increased the success rate of the treatment of gastrointestinal fistula. Methods: We present 6 cases of gastrointestinal fistula treated in our hospital in 2021: 3 cases of anastomotic fistula after esophageal cancer surgery, 2 cases of anastomotic fistula after gastric cancer surgery, and one case of esophageal rupture after trauma. With E-VAC and other adjuvant treatment measures, the gastrointestinal fistulas were eventually closed or significantly reduced. Results: Both local and systemic infections in all 6 patients were controlled with the use of E-VAC device, resulting in significant reduction or closure of fistulas. Conclusion: E-VAC devices can effectively help in the removal of the exudate and necrotic tissue around the fistula, promote the proliferation of granulation tissue, and support closure of the fistula. However, further improvements to the device are needed to improve patient comfort and operational safety. (c) 2022 S. Karger AG, Basel
C1 [Zhong, Wei-dong; Hu, Gen; Feng, Zhi-hua; Shao, Guo-yi] Nantong Univ, Dept Gastrointestinal Surg, Jiangyin Peoples Hosp, Jiangyin, Peoples R China.
   [Zhong, Wei-dong] Soochow Univ, Dept Gastroenterol, Affiliated Hosp 1, Suzhou, Peoples R China.
   [Shen, Wei-dong] Nantong Univ, Dept Gastroenterol, Jiangyin Peoples Hosp, Jiangyin, Peoples R China.
C3 Nantong University; Soochow University - China; Nantong University
RP Shao, GY (通讯作者)，Nantong Univ, Dept Gastrointestinal Surg, Jiangyin Peoples Hosp, Jiangyin, Peoples R China.; Shen, WD (通讯作者)，Nantong Univ, Dept Gastroenterol, Jiangyin Peoples Hosp, Jiangyin, Peoples R China.
EM shenwd1976@126.com; doctorash@vip.sina.com
RI Feng, Zhihua/AAW-4313-2021
CR Althof A, 2021, J PEDIAT SURG CASE R, V70, DOI 10.1016/j.epsc.2021.101885
   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
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NR 20
TC 3
Z9 3
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0257-2753
EI 1421-9875
J9 DIGEST DIS
JI Dig. Dis.
PD MAY
PY 2023
VL 41
IS 3
BP 506
EP 512
DI 10.1159/000526713
EA OCT 2022
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA R0IR2
UT WOS:000877149800001
PM 36288720
DA 2026-07-24
ER
PT J
AU Esen, E
   Saydam, M
   Guler, S
   Akinci, M
   Bahcecioglu, IB
   Gulcelik, MA
   Yilmaz, KB
AF Esen, Ebru
   Saydam, Mehmet
   Guler, Sumeyra
   Akinci, Melih
   Bahcecioglu, Ibrahim Burak
   Gulcelik, Mehmet Ali
   Yilmaz, Kerim Bora
TI Successful use of minimal invasive debridement plus negative pressure
   wound therapy under skin flap and axillary region for refractory
   postmastectomy seroma: A STROBE-compliant retrospective study
SO MEDICINE
LA English
DT Article
DE mastectomy; negative pressure wound therapy; seroma
ID INFLAMMATORY CYTOKINE LEVELS; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   ELECTROCAUTERY; COMPLICATIONS; MASTECTOMY; SCALPEL
AB Seroma is the most common wound complication due to dead space remaining after mastectomy and axillary dissection. Seroma formation, which causes pain and tension, together with the limitations of shoulder and arm movements, can cause wound healing problems that can progress to wound dehiscence and flap necrosis. The aim of our study was to investigate the effects of continuous drainage and negative pressure wound therapy (NPWT) in breast cancer patients with refractory postmastectomy seroma. This retrospectively designed study was conducted with 27 patients who were referred to our center between 2018 and 2021 due to refractory seroma after mastectomy. The inclusion criteria of the study were the cases who were planned minimally invasive debridement and NPWT due to having refractory seroma formation with at least 200 cc and having interventions more than 1 month after modified radical mastectomy (MRM), despite conventional treatment methods. All patients' demographics, disease stage, history of possible neoadjuvant therapy, comorbidities, body mass index (BMI), number of wound dressings with NPWT, and total amount of NPWT accumulation were enrolled and compared statistically. Twenty-seven patients included in the study underwent continuous drainage after debridement, and 5 (3-9) dressings were treated with NPWT. None of the patients experienced complications after debridement and NPWT administration. In refractory seroma cases seen after postmastectomy, NPWT especially for the management of debridement and dead space can be evaluated as an appropriate treatment method in patients with high flow rate seroma.
C1 [Esen, Ebru; Bahcecioglu, Ibrahim Burak; Gulcelik, Mehmet Ali] Univ Hlth Sci, Gulhane Res & Training Hosp, Dept Surg Oncol, Ankara, Turkey.
   [Saydam, Mehmet; Guler, Sumeyra] Univ Hlth Sci, Diskapi Res & Training Hosp, Dept Gen Surg, Ankara, Turkey.
   [Akinci, Melih; Yilmaz, Kerim Bora] Univ Hlth Sci, Gulhane Res & Training Hosp, Dept Gen Surg, Ankara, Turkey.
C3 Gulhane Training & Research Hospital; University of Health Sciences
   Turkey; Diskapi Yildirim Beyazit Training & Research Hospital;
   University of Health Sciences Turkey; University of Health Sciences
   Turkey; Gulhane Training & Research Hospital
RP Esen, E (通讯作者)，Univ Hlth Sci, Gulhane Res & Training Hosp, Dept Surg Oncol, Gen Tevf Saglam Cd 1, TR-06010 Kecioren Ankara, Turkey.
EM drebnesen@gmail.com
RI gulcelik, Mehmet/LKK-6450-2024; Yilmaz, Kerim Bora/HJI-8568-2023; esen,
   ebru/U-4613-2018
OI SAYDAM, Mehmet/0000-0003-0953-4589; Yilmaz, Kerim
   Bora/0000-0002-5514-4103; esen, ebru/0000-0003-3019-0872
CR Baltzer A, 2016, J DTSCH DERMATOL GES, V14, P850, DOI 10.1111/ddg.13090
   Bi HD, 2015, J PLAST RECONSTR AES, V68, P403, DOI 10.1016/j.bjps.2014.11.007
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   Özaslan C, 2010, TURK J MED SCI, V40, P751, DOI 10.3906/sag-0809-47
   Özdogan M, 2008, TURK J MED SCI, V38, P111
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   Sood Aditya, 2017, Eplasty, V17, pe25
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   van Bastelaar J, 2018, J SURG CASE REP, DOI 10.1093/jscr/rjy032
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   Yilmaz KB, 2011, J BREAST CANCER, V14, P58, DOI 10.4048/jbc.2011.14.1.58
NR 23
TC 3
Z9 5
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 28
PY 2022
VL 101
IS 43
AR e31634
DI 10.1097/MD.0000000000031634
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5V5UQ
UT WOS:000877294300053
PM 36316850
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fadaly, AS
   Abdellatif, GM
   Saeed, SE
   Brik, A
   Elsharawy, M
   Deebis, A
   Elfwakhry, RM
   Shemais, DS
AF Fadaly, Ahmed S.
   Abdellatif, Ghada Mohammed
   Saeed, Sameh E.
   Brik, Alaa
   Elsharawy, Mamdouh
   Deebis, Ahmed
   Elfwakhry, Rabab Mahmoud
   Shemais, Dina Said
TI Efficacy of Primary Closure Technique in Treatment of Post-Sternotomy
   Mediastinitis in Paediatric Group: A Randomized Controlled Trial
SO INTERNATIONAL JOURNAL OF GENERAL MEDICINE
LA English
DT Article
DE pediatric mediastinitis; post-cardiac surgery; primary closure;
   vacuum-assisted closure; interrupted mattress wires
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; INFECTIONS; THERAPY; RUPTURE;
   SITE
AB Purpose: To assess the efficacy of primary sternal closure technique compared to vacuum-assisted closure technique in treatment of post-cardiac surgery mediastinitis in paediatric age group. Additionally, assessed postoperative need for IV drug use, hospital stay length, wound and sternal healing and survival. Hypotheses: primary sternal closure is a reliable technique for treatment of poststernotomy mediastinitis following cardiac surgery in paediatric age group.Materials and Methods: A prospective randomized controlled trial included 217 pediatric patients developed post-cardiac surgery mediastinitis from 2016 to 2022. They were randomly divided into primary sternal closure group (A) and vacuum-assisted closure group (B) and operated by two cardiothoracic surgeons. Follow-up of the patients was done for 6-months duration following treatment of mediastinitis to assess postoperative need for hospitalization, IV drug use, wound complications, sternal stability and survival. Results: The final analysis included 101 patients in each group. The chance of survival over 6 months after surgery was more for primary sternal closure group (175.2) days versus (157.6) days for the vacuum-assisted closure group, with significant difference Log Rank test p-value (0.005). Duration for IV antibiotics use in the primary closure group was 8.55 +/- 3.57 and it was 32.61 +/- 8.39 showing high statistically significant difference (p<0.001). Patients in the primary closure group had earlier discharge from hospital 15.77 +/- 4.18 than vacuum assisted group 42.61 +/- 8.39, with high statistically significant difference (p<0.001). Primary closure group showed better sternal stability and sternotomy wound healing on clinical follow-up. Conclusion: Primary sternal closure technique is a favorable technique over vacuum-assisted closure technique for treatment of paediatric mediastinitis following cardiac surgery. The reinforced sternal closure technique is a reliable technique with promising results regarding IV drugs need, hospitalization duration, survival and sternotomy wound healing.
C1 [Fadaly, Ahmed S.; Saeed, Sameh E.; Brik, Alaa; Elsharawy, Mamdouh; Deebis, Ahmed; Shemais, Dina Said] Zagazig Univ, Fac Human Med, Dept Cardiothorac Surg, Zagazig, Egypt.
   [Abdellatif, Ghada Mohammed] Zagazig Univ, Fac Human Med, Dept Pediat Med, Zagazig, Egypt.
   [Elfwakhry, Rabab Mahmoud] Zagazig Univ, Fac Human Med, Dept Radiodiag, Zagazig, Egypt.
   [Shemais, Dina Said] Zagazig Univ, Dept cardiothorac Surg, Zagazig 44631, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University; Egyptian Knowledge Bank (EKB); Zagazig
   University; Egyptian Knowledge Bank (EKB); Zagazig University
RP Shemais, DS (通讯作者)，Zagazig Univ, Dept cardiothorac Surg, Zagazig 44631, Egypt.
EM drdinashemais010@gmail.com
RI ; Deebis, Ahmed/ABD-9553-2021; Shemais, Dina/KYR-3075-2024; Saeed,
   S./GQH-8038-2022
OI Said Shemais, Dina/0000-0001-6976-7769; Deebis,
   Ahmed/0000-0002-3519-172X; 
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   Al-Sehly AA, 2005, ANN THORAC SURG, V80, P2314, DOI 10.1016/j.athoracsur.2005.05.035
   Basha Mohammad Abd Alkhalik, 2021, Int J Gen Med, V14, P9287, DOI [10.2147/ijgm.s343124, 10.2147/IJGM.S343124]
   Copeland H, 2018, WORLD J PEDIATR CONG, V9, P440, DOI 10.1177/2150135118772494
   De Cicco G, 2019, J THORAC DIS, V11, P4538, DOI 10.21037/jtd.2019.10.79
   Durandy Y, 2010, WORLD J CARDIOL, V2, P391, DOI 10.4330/wjc.v2.i11.391
   Fleck Tatjana, 2006, Interact Cardiovasc Thorac Surg, V5, P285, DOI 10.1510/icvts.2005.122424
   Hiramatsu Takeshi, 2008, Asian Cardiovasc Thorac Ann, V16, pe45
   Kadohama T, 2008, ANN THORAC SURG, V85, P1094, DOI 10.1016/j.athoracsur.2007.09.004
   Levy I, 2003, J HOSP INFECT, V53, P111, DOI 10.1053/jhin.2002.1359
   Mangukia CV, 2014, J CARDIAC SURG, V29, P74, DOI 10.1111/jocs.12243
   Nateghian A, 2004, AM J INFECT CONTROL, V32, P397, DOI 10.1016/j.ajic.2004.03.004
   Ohye RG, 2004, J THORAC CARDIOV SUR, V128, P480, DOI 10.1016/j.jtcvs.2004.04.023
   Onan IS, 2019, ARTIF ORGANS, V43, P119, DOI 10.1111/aor.13321
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   Steigelman MB, 2009, ANN THORAC SURG, V88, P1277, DOI 10.1016/j.athoracsur.2009.06.027
   Ugaki S, 2010, INTERACT CARDIOV TH, V11, P247, DOI 10.1510/icvts.2010.235903
   Zeitani J, 2006, J THORAC CARDIOV SUR, V132, P38, DOI 10.1016/j.jtcvs.2006.03.015
NR 18
TC 0
Z9 0
U1 0
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7074
J9 INT J GEN MED
JI Int. J. Gen. Med.
PY 2022
VL 15
BP 7929
EP 7939
DI 10.2147/IJGM.S388446
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5V9TQ
UT WOS:000877566900001
PM 36317099
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pascale, R
   Maccaro, A
   Mikus, E
   Baldassarre, M
   Tazza, B
   Esposito, F
   Rinaldi, M
   Tenti, E
   Ambretti, S
   Albertini, A
   Viale, P
   Giannella, M
   Bartoletti, M
AF Pascale, Renato
   Maccaro, Angelo
   Mikus, Elisa
   Baldassarre, Maurizio
   Tazza, Beatrice
   Esposito, Fabio
   Rinaldi, Matteo
   Tenti, Elena
   Ambretti, Simone
   Albertini, Alberto
   Viale, Pierluigi
   Giannella, Maddalena
   Bartoletti, Michele
TI A retrospective multicentre study on dalbavancin effectiveness and
   cost-evaluation in sternotomic wound infection treatment: DALBA SWIT
   Study
SO JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
LA English
DT Article
DE Sternal wound infection; Dalbavancin; Teicoplanin; Daptomycin; Cardiac
   surgery; Cost evaluation
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS;
   SURVIVAL; SURGERY
AB Objective: To evaluate the cost-effectiveness of dalbavancin compared with standard of care (SoC) treatment as daptomycin or teicoplanin in patients with sternal wound infections (SWI). Methods: Multicentre retrospective study of patients diagnosed with SWI from January 2016 to December 2019 at two cardiac surgery facilities treated with dalbavancin, teicoplanin or daptomycin. Patients with SWI treated with dalbavancin were compared with SoC to evaluate resolution of infection at 90 and 180 days from infection diagnosis, length of stay (LoS) and management costs. Results: 48 patients with SWI were enrolled, 25 (50%) male, median age 67 (60-73) years, Charlson index score 5 (4-7). Fifteen patients were treated with dalbavancin (31%) and 33 with SoC (69%): teicoplanin in 21 (63%), and daptomycin in 12 (37%). Staphylococcus species were the most frequent isolates (44, 92%), mostly (84%) resistant to methicillin. All patients were treated with surgical debridement followed by negative pressure wound therapy. Wound healing at day 90 and 180 was achieved in 46 (95.8%) and 34 (82.9%) of patients, respectively. A shorter length of hospitalization in patients treated with dalbavancin compared with SoC [12 (7-18) days vs 22 (12-36) days, p:0.009] was found. Treatment with dalbavancin resulted in total cost savings of euro 16 026 (95% CI 5976-26 076, P < 0.001). Savings were mainly related to the LoS that was significantly shorter in the dalbavancin group, generating significantly lower cost compared to SoC group. Conclusion: Dalbavancin treatment of sternal wound infections is effective and seems to reduce hospitalization length, leading to significantly lower costs.(c) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
C1 [Pascale, Renato; Maccaro, Angelo; Esposito, Fabio; Rinaldi, Matteo; Viale, Pierluigi; Giannella, Maddalena; Bartoletti, Michele] IRCCS Azienda Osped Univ Bologna, Dept Integrated Management Infect Risk, Infect Dis Unit, Bologna, Italy.
   [Pascale, Renato; Tazza, Beatrice; Viale, Pierluigi; Giannella, Maddalena; Bartoletti, Michele] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy.
   [Mikus, Elisa; Albertini, Alberto] Maria Cecilia Hosp, GVM Care & Res, Cotignola, Ravenna, Italy.
   [Baldassarre, Maurizio] IRCCS Azienda Osped Univ Bologna, UO Med Semiot, Bologna, Italy.
   [Ambretti, Simone] IRCCS Azienda Osped Univ Bologna, Operat Unit Microbiol, Bologna, Italy.
   [Tazza, Beatrice] Univ Bologna, Dept Med & Surg Sci, Infect Dis Unit, IRCCS Policlin St Orsola, Via Massarenti 11, I-40138 Bologna, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of
   Bologna; Maria Cecilia Hospital; IRCCS Azienda Ospedaliero-Universitaria
   di Bologna; IRCCS Azienda Ospedaliero-Universitaria di Bologna;
   University of Bologna
RP Tazza, B (通讯作者)，Univ Bologna, Dept Med & Surg Sci, Infect Dis Unit, IRCCS Policlin St Orsola, Via Massarenti 11, I-40138 Bologna, Italy.
EM beatrice.tazza@unibo.it
RI Rinaldi, Matteo/AAB-8102-2019; Albertini, Alberto/KQV-4794-2024; Tenti,
   Elena/P-7915-2018; Bartoletti, Michele/K-4621-2018; Baldassarre,
   Maurizio/K-6129-2016; Mikus, Elisa/ABO-4522-2022; Pascale,
   Renato/ABM-9366-2022; GIANNELLA, MADDALENA/K-9090-2016; Ambretti,
   Simone/G-9788-2018
OI Rinaldi, Matteo/0000-0002-3568-5973; Maccaro,
   Angelo/0000-0002-0065-7251; Albertini, Alberto/0000-0001-5374-4298;
   Tenti, Elena/0000-0001-6974-0849; Bartoletti,
   Michele/0000-0002-1099-3283; Baldassarre, Maurizio/0000-0001-7865-394X;
   Mikus, Elisa/0000-0003-2892-8700; Pascale, Renato/0000-0003-2687-4235; 
CR Agarwal R, 2018, CLIN MICROBIOL INFEC, V24, P361, DOI 10.1016/j.cmi.2017.08.028
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   [Anonymous], TARGOSID PRODUCT INF
   [Anonymous], CUBICIN PRODUCT INFO
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   Das B, 2008, PAK J PHARM SCI, V21, P78
   Dubert M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139122
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NR 26
TC 8
Z9 8
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-7165
EI 2213-7173
J9 J GLOB ANTIMICROB RE
JI J. Glob. Antimicrob. Resist.
PD SEP
PY 2022
VL 30
BP 390
EP 394
DI 10.1016/j.jgar.2022.07.018
EA AUG 2022
PG 5
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA 5W4XG
UT WOS:000877918200001
PM 35878780
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Dawson, VJ
   Echalier, EL
   Vu, B
   Liao, S
   Goddard, J
   Hink, E
AF Dawson, Valerie J.
   Echalier, E. Lacey
   Vu, Brian
   Liao, Sophie
   Goddard, Julie
   Hink, Eric
TI Severe Diesel Injection Injury to the Face, Neck and Orbit: Surgical
   Management and Critical Care Considerations
SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID PRESSURE WOUND THERAPY; GREASE-GUN INJURY
AB The purpose of this report is to discuss high-pressure injection injuries involving the face and orbit and discuss factors affecting prognosis and management as these injuries are rare and uniquely challenging to manage given the complex anatomy and extensive damage that may occur. In this case, we present severe injury to the left orbit, maxillofacial region, and neck of a 29-year-old male who suffered a high-pressure diesel injection injury requiring several surgical debridements, intensive care unit (ICU) level care, and ultimately sub-total exenteration. Initial management involved systemic antibiotics, steroids, and surgical debridement; however, our patient experienced subsequent rapid deterioration resulting in admission for more aggressive subspecialty intervention. Decision-making was guided by serial CT of the face and orbits, and C-reactive protein (CRP) levels in addition to the physical examination. His course was complicated by progressive extensive soft tissue necrosis requiring 8 surgical debridements and optic nerve tenting despite orbital decompression resulting in loss of the OS. Ultimately, definitive treatment required sub-total exenteration and negative wound pressure therapy over the orbit followed by eyelid reconstruction as an outpatient. We conclude that without prompt recognition and meticulous debridement, the resultant injury from high-pressure injection injuries can be devastating and lead to permanent vision loss, loss of an eye, loss of facial function, and airway compromise depending on the location of the injury. A multi-disciplinary team involving oculoplastics, otolaryngology, infectious disease, and ICU should be assembled based on the complexity of this injury and its sequela. CRP can be useful to monitor patient recovery and the need for further surgical intervention. When debridement results in complex wounds over the orbit and face, negative pressure wound therapy should be considered.
C1 [Dawson, Valerie J.; Vu, Brian; Liao, Sophie; Hink, Eric] Univ Colorado, Dept Ophthalmol, Sch Med, Aurora, CO 80045 USA.
   [Echalier, E. Lacey] Med Eye Ctr Medford Oregon, Medford, OR USA.
   [Goddard, Julie] Univ Colorado, Dept Otolaryngol, Sch Med, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz;
   University of Colorado System; University of Colorado Anschutz
RP Dawson, VJ (通讯作者)，Univ Colorado, Dept Ophthalmol, Sch Med, Aurora, CO 80045 USA.
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NR 13
TC 2
Z9 3
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0740-9303
EI 1537-2677
J9 OPHTHAL PLAST RECONS
JI Ophthalmic Plast. Reconstr. Surg.
PD NOV-DEC
PY 2022
VL 38
IS 6
BP E173
EP E176
DI 10.1097/IOP.0000000000002230
PG 4
WC Ophthalmology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology; Surgery
GA 5X0FC
UT WOS:000878281900005
PM 35604381
DA 2026-07-24
ER
PT J
AU Zhang, S
   Zhou, ZM
   Xu, J
AF Zhang, Shuo
   Zhou, Zimo
   Xu, Jing
TI Undifferentiated pleomorphic sarcoma of the lateral thigh with KRAS/NF1
   co-mutation recurred after repetitive surgical resection: A case report
   and review of the literature
SO FRONTIERS IN SURGERY
LA English
DT Review
DE undifferentiated pleomorphic sarcoma; recurrence; KRAS; NF1; case report
ID MALIGNANT FIBROUS HISTIOCYTOMA; ATYPICAL FIBROXANTHOMA
AB Undifferentiated pleomorphic sarcoma (UPS), a rare soft tissue sarcoma subtype, mainly occurs in the deep parts of the limbs and trunk, observed as rapidly growing painless lumps, rarely located under the skin or protrudes from the skin surface. The risk of recurrence and metastasis is associated with multiple factors. Mutation of tumor gene, tumor occurrence, location and depth of invasion, and tumor size have great influence on prognosis. In this study, we described a case of UPS with KRAS/NF1 co-mutation. This case had undergone UPS extended resection for four times combined with chemotherapy in another hospital. The resection area was more than 3 cm, and tumor relapsed after all operations. This time, the tumor protruded from the left lateral surface with ulceration and infection. Due to multiple surgeries, the anatomy of the lateral femoral vessels has been seriously damaged. We performed expanded tumor resection and adjacent flap transfer repair; meanwhile, vacuum sealing drainage (VSD)-negative pressure closed the drainage, and the patient recovered well after surgery. After surgery, the patient was transferred to the Department of Oncology for chemotherapy. There was no recurrence after 6 months of follow-up. Gene mutation plays an important role in UPS recurrence and metastasis. At the same time, occurrence and location, depth, and size of UPS have great influence on the prognosis. Deeper exploration and expanded resection are important for the prognosis of UPS.
C1 [Zhang, Shuo; Xu, Jing] Bengbu Med Coll, Affiliated Hosp 1, Dept Plast Surg, Bengbu, Peoples R China.
   [Zhou, Zimo] China Med Univ, Shengjing Hosp, Dept Orthoped, Shenyang, Peoples R China.
C3 Bengbu Medical University; China Medical University
RP Xu, J (通讯作者)，Bengbu Med Coll, Affiliated Hosp 1, Dept Plast Surg, Bengbu, Peoples R China.
EM xj.69@163.com
RI ; Zhou, Zimo/AAD-3815-2021
OI 张, 硕/0000-0003-4223-3411; Zhou, Zimo/0000-0003-0670-9419
FU Natural Science Research Key Project of Anhui Province;  [KJ2020A0576]
FX This work was supported by grants from the Natural Science Research Key
   Project of Anhui Province (Grant No. KJ2020A0576).
CR Akatsu T, 2005, DIGEST DIS SCI, V50, P2214, DOI 10.1007/s10620-005-3037-3
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NR 19
TC 2
Z9 2
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD OCT 21
PY 2022
VL 9
AR 842054
DI 10.3389/fsurg.2022.842054
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5Z2TU
UT WOS:000879830800001
PM 36338647
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kitano, D
   Takahashi, H
   Nomura, T
   Okada, K
   Terashi, H
   Sakakibara, S
AF Kitano, Daiki
   Takahashi, Hiroaki
   Nomura, Tadashi
   Okada, Kenji
   Terashi, Hiroto
   Sakakibara, Shunsuke
TI A new clinical classification and reconstructive strategy for
   post-sternotomy surgical site infection
SO REGENERATIVE THERAPY
LA English
DT Article
DE Surgical site infection; Cardiovascular surgery; Mediastinitis;
   Classification
ID MANAGEMENT; MEDIASTINITIS
AB Introduction: Post-sternotomy surgical site infection (SSI) is a serious complication of cardiovascular surgery. Here, we proposed a new clinical classification and reconstructive strategy for this condition. Methods: A retrospective study based on medical records was performed on 100 consecutive cases requiring wound management by plastic surgeons for post-sternotomy SSI at Kobe University Hospital between January 2009 and December 2021. We classified 100 cases into four categories according to the anatomical invasiveness of the infection (type 1, superficial SSI; type 2, sternal osteomyelitis; type 3, mediastinitis; and type 4, aortic graft infection). The standard treatment plan comprised initial debridement, negative pressure wound therapy with continuous irrigation, and reconstructive surgery. Reconstructive methods and their outcomes (in-hospital mortality rate, follow-up period, and infection recurrence rate) were investigated for each SSI category.Results: There were nine SSI cases in type 1, 28 in type 2, 25 in type 3, and 38 in type 4. The pectoralis major (PM) muscle advancement flap was mainly selected in types 1 and 2 (100 and 70.4%, respectively), while the omental flap or latissimus dorsi (LD) myocutaneous flaps were mainly selected in types 3 and 4 (77.3 and 81.8%, respectively) for reconstructive surgery. The in-hospital mortality rates for types 1, 2, 3, 4 were 44.4, 3.6, 12.0, and 15.8%, respectively. The mean follow-up periods for types 1, 2, 3, 4 were 542.8, 1514.5, 1154.5, and 831.1 days, respectively. Infection recurrence rates for types 1, 2, 3, 4 were 0,11.5, 13.3, and 19.2%, respectively. All of these recurrent cases, except for 4 cases of type 4 that required surgical intervention, were treated with conservative wound management.Conclusion: A volume-rich flap (omental or LD flap) was required to fill the dead space after debridement in mediastinitis (type 3) or aortic graft infection (type 4), whereas superficial SSI (type 1) or sternal osteomyelitis (type 2) received a less-invasive flap (PM muscle advancement flap). Our new classification method was based on the anatomical invasiveness of the infection, providing both a simple and easy diagnosis and definitive treatment strategy.(c) 2022, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).
C1 [Kitano, Daiki; Nomura, Tadashi; Terashi, Hiroto; Sakakibara, Shunsuke] Kobe Univ, Grad Sch Med, Dept Plast Surg, Kobe, Japan.
   [Takahashi, Hiroaki; Okada, Kenji] Kobe Univ, Grad Sch Med, Dept Cardiovasc Surg, Kobe, Japan.
   [Kitano, Daiki] Kobe Univ, Grad Sch Med, Dept Plast Surg, 7-5-2,Kusunoki Cho,Chuo Ku, Kobe 6500017, Japan.
C3 Kobe University; Kobe University; Kobe University
RP Kitano, D (通讯作者)，Kobe Univ, Grad Sch Med, Dept Plast Surg, 7-5-2,Kusunoki Cho,Chuo Ku, Kobe 6500017, Japan.
EM dkitano.kobe.prs@gmail.com
RI Nomura, Tadashi/KYQ-6225-2024; Sakakibara, Shunsuke/JWP-3331-2024
OI Nomura, Tadashi/0000-0002-0321-0770; TERASHI,
   HIROTO/0000-0002-5939-6893; Takahashi, Hiroaki/0000-0002-0364-5598; 
FU Grants-in-Aid for Scientific Research [20K09864] Funding Source: KAKEN
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NR 19
TC 1
Z9 2
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3204
J9 REGEN THER
JI Regen. Ther.
PD DEC
PY 2022
VL 21
BP 519
EP 526
DI 10.1016/j.reth.2022.10.007
EA OCT 2022
PG 8
WC Cell & Tissue Engineering; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA 5Z6SH
UT WOS:000880100300007
PM 36382133
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Drefs, M
   Schardey, J
   Von Ehrlich-Treuenstätt, V
   Wirth, U
   Burian, M
   Zimmermann, P
   Werner, J
   Kühn, F
AF Drefs, Moritz
   Schardey, Josefine
   Von Ehrlich-Treuenstaett, Viktor
   Wirth, Ulrich
   Burian, Maria
   Zimmermann, Petra
   Werner, Jens
   Kuehn, Florian
TI Endoscopic Treatment Options for Gastrointestinal Leaks
SO VISCERAL MEDICINE
LA English
DT Review
DE Gastrointestinal leakage; Endoscopy; Anastomotic leak; Endoscopic vacuum
   treatment; Endosponge
ID VACUUM-ASSISTED CLOSURE; LOW ANTERIOR RESECTION; POUCH-ANAL ANASTOMOSIS;
   ENDO-SPONGE TREATMENT; PORE FILM DRAINAGE; LONG-TERM EFFICACY;
   RECTAL-CANCER; HARTMANNS PROCEDURE; INTERNATIONAL CONSENSUS; COLORECTAL
   ANASTOMOSES
AB Background: Spontaneous or postoperative gastrointestinal defects are still life-threatening complications with elevated morbidity and mortality. Recently, endoscopic treatment options - up and foremost endoscopic vacuum therapy (EVT) - have become increasingly popular and have shown promising results in these patients. Methods: We performed an electronic systematic search of the MEDLINE databases (PubMed, EMBASE, and Cochrane) and searched for studies evaluating endoscopic options for the treatment of esophageal and colorectal leakages and/or perforations until March 2022. Results: The closure rate of both esophageal and colorectal defects by EVT is high and even exceeds the results of surgical revision in parts. Out of all endoscopic treatment options, EVT shows most evidence and appears to have the highest therapeutic success rates. Furthermore, EVT for both indications had a low rate of serious complications without relevant in-hospital mortality. In selected patients, EVT can be applied without fecal diversion and transferred to an outpatient setting. Conclusion: Despite multiple endoscopic treatment options, EVT is increasingly becoming the new gold standard in endoscopic treatment of extraperitoneal defects of the upper and lower GI tract with localized peritonitis or mediastinitis and without close proximity to major blood vessels. However, further prospective, comparative studies are needed to strengthen the current evidence.
C1 [Drefs, Moritz; Schardey, Josefine; Von Ehrlich-Treuenstaett, Viktor; Wirth, Ulrich; Burian, Maria; Zimmermann, Petra; Werner, Jens; Kuehn, Florian] Univ Hosp Munich, Dept Gen Visceral & Transplant Surg, Munich, Germany.
C3 University of Munich
RP Drefs, M (通讯作者)，Univ Hosp Munich, Dept Gen Visceral & Transplant Surg, Munich, Germany.
EM moritz.drefs@med.uni-muenchen.de
RI ; Schardey, Josefine/OWA-4498-2025
OI Burian, Maria/0000-0001-6710-1621; Drefs, Moritz/0000-0002-0662-7643;
   Kühn, Florian/0000-0001-9830-3015; Schardey,
   Josefine/0000-0002-7933-2977
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NR 110
TC 10
Z9 11
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2297-4725
EI 2297-475X
J9 VISC MED
JI Visc. Med.
PD OCT
PY 2022
VL 38
IS 5
BP 311
EP 321
DI 10.1159/000526759
PG 11
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 5Z8BF
UT WOS:000880191400003
PM 37970585
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Haidari, S
   Ijpma, FFA
   Metsemakers, WJ
   Maarse, W
   Vogely, HC
   Ramsden, AJ
   McNally, MA
   Govaert, GAM
AF Haidari, Susan
   Ijpma, Frank F. A.
   Metsemakers, Willem-Jan
   Maarse, Wies
   Vogely, H. Charles
   Ramsden, Alex J.
   McNally, Martin A.
   Govaert, Geertje A. M.
TI The Role of Negative-Pressure Wound Therapy in Patients with
   Fracture-Related Infection: A Systematic Review and Critical Appraisal
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SEALING DRAINAGE; INTERNAL-FIXATION;
   MANAGEMENT; NONUNION; QUALITY
AB Introduction. Fracture-related infection (FRI) is a severe musculoskeletal complication in orthopedic trauma surgery, causing challenges in bony and soft tissue management. Currently, negative-pressure wound therapy (NPWT) is often used as temporary coverage for traumatic and surgical wounds, also in cases of FRI. However, controversy exists about the impact of NPWT on the outcome in FRI, specifically on infection recurrence. Therefore, this systematic review qualitatively assesses the literature on the role of NPWT in the management of FRI. Methods. A literature search of the PubMed, Embase, and Web of Science database was performed. Studies that reported on infection recurrence related to FRI management combined with NPWT were eligible for inclusion. Quality assessment was done using the PRISMA statement and the Newcastle-Ottawa Quality Assessment Scale. Results. After screening and quality assessment of 775 unique identified records, eight articles could be included for qualitative synthesis. All eight studies reported on infection recurrence, which ranged from 2.8% to 34.9%. Six studies described wound healing time, varying from two to seven weeks. Four studies took repeated microbial swabs during subsequent vacuum dressing changes. One study reported newly detected pathogens in 23% of the included patients, and three studies did not find new pathogens. Conclusion. This review provides an assessment of current literature on the role of NPWT in the management of soft tissue defects in patients with FRI. Due to the lack of uniformity in included studies, conclusions should be drawn with caution. Currently, there is no clear scientific evidence to support the use of NPWT as definitive treatment in FRI. At this stage, we can only recommend early soft tissue coverage (within days) with a local or free flap. NPWT may be safe for a few days as temporarily soft tissue coverage until definitive soft tissue management could be performed. However, comparative studies between NPWT and early wound closure in FRI patients are needed.
C1 [Haidari, Susan; Govaert, Geertje A. M.] Univ Med Ctr Utrecht, Dept Trauma Surg, Utrecht, Netherlands.
   [Ijpma, Frank F. A.] Univ Med Ctr Groningen, Dept Trauma Surg, Groningen, Netherlands.
   [Metsemakers, Willem-Jan] Univ Hosp Leuven, Dept Trauma Surg, Leuven, Belgium.
   [Maarse, Wies] Univ Med Ctr Utrecht, Dept Plast Reconstruct & Hand Surg, Utrecht, Netherlands.
   [Vogely, H. Charles] Univ Med Ctr Utrecht, Dept Orthoped Surg, Utrecht, Netherlands.
   [Ramsden, Alex J.] Oxford Univ Hosp NHS Fdn Trust, Dept Plast & Reconstruct Surg, Oxford, England.
   [Ramsden, Alex J.; McNally, Martin A.] Nuffield Orthoped Ctr, Bone Infect Unit, Oxford, England.
C3 Utrecht University; Utrecht University Medical Center; University of
   Groningen; KU Leuven; University Hospital Leuven; Utrecht University;
   Utrecht University Medical Center; Utrecht University; Utrecht
   University Medical Center; Oxford University Hospitals NHS Foundation
   Trust; Nuffield Orthopaedic Centre
RP Govaert, GAM (通讯作者)，Univ Med Ctr Utrecht, Dept Trauma Surg, Utrecht, Netherlands.
EM g.a.m.govaert@umcutrecht.nl
RI Metsemakers, Willem-Jan/F-8647-2016; IJpma, Frank/AAH-6350-2019
OI Metsemakers, Willem-Jan/0000-0002-4114-9093; McNally,
   Martin/0000-0003-2003-9044; IJpma, Frank/0000-0002-9420-2732; Haidari,
   Susan/0000-0003-0425-7543
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NR 63
TC 15
Z9 18
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD OCT 19
PY 2021
VL 2021
AR 7742227
DI 10.1155/2021/7742227
PG 11
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 6A1NK
UT WOS:000880427100005
PM 34722772
OA Green Submitted, Green Accepted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Prete, F
   De Luca, GM
   Pasculli, A
   Di Meo, G
   Poli, E
   Sgaramella, LI
   Panzera, P
   Vittore, F
   Filoia, A
   Catena, F
   Testini, M
   Gurrado, A
AF Prete, Francesco
   De Luca, Giuseppe Massimiliano
   Pasculli, Alessandro
   Di Meo, Giovanna
   Poli, Elisabetta
   Sgaramella, Lucia Ilaria
   Panzera, Piercarmine
   Vittore, Francesco
   Filoia, Antonella
   Catena, Fausto
   Testini, Mario
   Gurrado, Angela
TI Retrospective Study of Indications and Outcomes of Open Abdomen with
   Negative Pressure Wound Therapy Technique for Abdominal Sepsis in a
   Tertiary Referral Centre
SO ANTIBIOTICS-BASEL
LA English
DT Article
DE abdominal sepsis; open abdomen; damage control surgery; negative
   pressure wound therapy; acute care surgery
ID MEDIATED FASCIAL TRACTION; DAMAGE-CONTROL; CLOSURE; MANAGEMENT; VACUUM;
   CLASSIFICATION; METAANALYSIS; SURGERY
AB In patients with advanced sepsis from abdominal disease, the open abdomen (OA) technique as part of a damage control surgery (DCS) approach enables relook surgery to control infection, defer intestinal anastomosis, and prevent intra-abdominal hypertension. Limited evidence is available on key outcomes, such as mortality and rate of definitive fascial closure (DFC), which are needed for surgeons to select patients and adequate therapeutic strategies. Abdominal closure with negative pressure wound therapy (NPWT) has shown rates of DFC around 90%. We conducted a retrospective study to evaluate in-hospital survival and factors associated with mortality in acute, non-trauma patients treated using the OA technique and NPWT for sepsis from abdominal disease. Fifty consecutive patients treated using the OA technique and NPWT between February 2015 and July 2022 were included. Overall mortality was 32%. Among surviving patients, 97.7% of cases reached DFC, and the overall complication rate was 58.8%, with one case of entero-atmospheric fistula. At univariable analysis, age (p = 0.009), ASA IV status (<0.001), Mannheim Peritonitis Index > 30 (p = 0.001) and APACHE II score (p < 0.001) were associated with increased mortality. At multivariable analysis, higher APACHE II was a predictor of in-hospital mortality (OR 2.136, 95% CI 1.08-4.22; p = 0.029). Although very resource-intensive, DCS and the OA technique are valuable tools to manage patients with advanced abdominal sepsis, allowing reduced mortality and high DFC rates.
C1 [Prete, Francesco; De Luca, Giuseppe Massimiliano; Pasculli, Alessandro; Di Meo, Giovanna; Poli, Elisabetta; Sgaramella, Lucia Ilaria; Panzera, Piercarmine; Vittore, Francesco; Filoia, Antonella; Testini, Mario; Gurrado, Angela] Univ Bari Aldo Moro, Med Sch, Acad Gen Surg Unit, Dept Biomed Sci & Human Oncol, I-70121 Bari, Italy.
   [Catena, Fausto] Maggiore Hosp Parma, Emergency & Trauma Surg Dept, I-43126 Parma, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Prete, F (通讯作者)，Univ Bari Aldo Moro, Med Sch, Acad Gen Surg Unit, Dept Biomed Sci & Human Oncol, I-70121 Bari, Italy.
EM francesco.prete@uniba.it
RI ; Sgaramella, Lucia Ilaria/LMQ-3099-2024; Gurrado, Angela/HZM-4980-2023;
   Prete, Francesco/J-7141-2019; Panzera, Piercarmine/HOC-2022-2023;
   Pasculli, Alessano/M-4541-2018; Di Meo, Giovanna/JRR-9074-2023
OI Testini, Mario/0000-0002-9297-4894; Sgaramella, Lucia
   Ilaria/0000-0002-6087-4119; Gurrado, Angela/0000-0002-2009-5831; Prete,
   Francesco/0000-0003-0426-8752; Panzera, Piercarmine/0000-0002-5231-8550;
   Pasculli, Alessano/0000-0003-2276-2383; Di Meo,
   Giovanna/0000-0002-7012-8654
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NR 35
TC 5
Z9 9
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2079-6382
J9 ANTIBIOTICS-BASEL
JI Antibiotics-Basel
PD NOV
PY 2022
VL 11
IS 11
AR 1498
DI 10.3390/antibiotics11111498
PG 10
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA 6A5FR
UT WOS:000880681900001
PM 36358153
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU White, AJ
   Gilad, R
   Motivala, S
   Fiani, B
   Rasouli, J
AF White, Alexandra Jeanne
   Gilad, Ronit
   Motivala, Soriaya
   Fiani, Brian
   Rasouli, Jonathan
TI Negative Pressure Wound Therapy in Spinal Surgery
SO BIOENGINEERING-BASEL
LA English
DT Review
DE spine surgery; surgical site infection; wound management; wound
   dressing; infection prevention; wound healing
AB Negative pressure wound therapy (NPWT) has demonstrated promise in the management of surgical site infections as well as assisting in surgical wound healing. In this manuscript, we describe the mechanisms and applications of NPWT for surgical wounds and existing evidence for NPWT in cardiac, plastic, and general surgery, followed by a discussion of the emerging evidence base for NPWT in spinal surgery. We also discuss the different applications of NPWT for open wounds and closed incisions, and the promise of newer closed-incision NPWT (ciNPWT) devices. There is nominal but promising prospective evidence on NPWT's efficacy in select at-risk populations for post-operative wound complications after spinal surgery. As there is currently a paucity of robust clinical evidence on its efficacy, rigorous randomized prospective clinical trials are needed.
C1 [White, Alexandra Jeanne] Case Western Reserve Univ, Lerner Coll Med, Cleveland Clin, Cleveland, OH 44195 USA.
   [Gilad, Ronit; Motivala, Soriaya; Rasouli, Jonathan] Staten Isl Univ Hosp, Northwell Hlth, Staten Isl, NY 10301 USA.
   [Fiani, Brian] New York Presbyterian Hosp, Weill Cornell Med Ctr, Dept Neurosurg, New York, NY 10065 USA.
C3 Cleveland Clinic Foundation; University System of Ohio; Case Western
   Reserve University; Northwell Health; Cornell University; Weill Cornell
   Medical Center; Weill Cornell Medicine; NewYork-Presbyterian Hospital
RP Rasouli, J (通讯作者)，Staten Isl Univ Hosp, Northwell Hlth, Staten Isl, NY 10301 USA.
EM jrasouli1@northwell.edu
RI ; Rasouli, Jonathan/AAF-2742-2020
OI White, Alexandra/0000-0003-4704-6578; 
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NR 61
TC 10
Z9 10
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2306-5354
J9 BIOENGINEERING-BASEL
JI Bioengineering-Basel
PD NOV
PY 2022
VL 9
IS 11
AR 614
DI 10.3390/bioengineering9110614
PG 10
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 6B0IP
UT WOS:000881028300001
PM 36354525
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tsuji, M
   Kakuda, N
   Bujo, C
   Saito, A
   Ishida, J
   Amiya, E
   Hatano, M
   Shimada, A
   Imai, H
   Kimura, M
   Ando, M
   Kinoshita, O
   Yamauchi, H
   Komuro, I
   Ono, M
AF Tsuji, Masaki
   Kakuda, Nobutaka
   Bujo, Chie
   Saito, Akihito
   Ishida, Junichi
   Amiya, Eisuke
   Hatano, Masaru
   Shimada, Asako
   Imai, Hiroko
   Kimura, Mitsutoshi
   Ando, Masahiko
   Kinoshita, Osamu
   Yamauchi, Haruo
   Komuro, Issei
   Ono, Minoru
TI Prophylactic negative pressure wound therapy is not effective for
   preventing driveline infection following left ventricular assist device
   implantation
SO ARTIFICIAL ORGANS
LA English
DT Article
DE driveline infection; left ventricular assist device; negative pressure
   wound therapy
ID SITE INFECTION; MANAGEMENT; SUPPORT; COMPLICATIONS; LAPAROTOMY; CLOSURE;
   TRIAL
AB Background Driveline infection (DLI) following left ventricular assist device (LVAD) implantation remains an unresolved problem. Negative pressure wound therapy (NPWT) promotes wound healing by applying negative pressure on the surface of the wound. Recently, the prophylactic application of NPWT to closed surgical incisions has decreased surgical site infections in various postsurgical settings. Therefore, we evaluated the efficacy and safety of prophylactic NPWT for preventing DLI in patients with LVAD implantation. Methods Prophylactic NPWT was provided to 50 patients who received continuous-flow LVADs as bridge-to-transplant therapy at our institution between May 2018 and October 2020 (NPWT group). The negative pressure dressing was applied immediately after surgery and retained on the driveline exit site for 7 days with a continuous application of -125 mm Hg negative pressure. The primary outcome was DLI within 1 year of LVAD implantation. We compared the rate of DLI incidence in the NPWT group with that in the historical control cohort (50 patients) treated with the standard dressing (SD) who received LVAD implantation between July 2015 and April 2018 (SD group). Results No severe complications were associated with the NPWT. During the follow-up period, DLI was diagnosed in 16 participants (32%) in the NPWT group and 21 participants (42%) in the SD group. The rates of DLI incidence and freedom from DLI did not differ between groups (p = 0.30 and p = 0.63). Conclusions Prophylactic NPWT at the driveline exit site was safe following LVAD implantation. However, it did not significantly reduce the risk of DLI.
C1 [Tsuji, Masaki; Kakuda, Nobutaka; Bujo, Chie; Saito, Akihito; Ishida, Junichi; Amiya, Eisuke; Hatano, Masaru; Komuro, Issei] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan.
   [Bujo, Chie; Amiya, Eisuke] Univ Tokyo, Dept Therapeut Strategy Heart Failure, Tokyo, Japan.
   [Hatano, Masaru] Univ Tokyo, Dept Adv Med Ctr Heart Failure, Tokyo, Japan.
   [Shimada, Asako; Imai, Hiroko] Univ Tokyo, Grad Sch Med, Dept Organ Transplantat, Tokyo, Japan.
   [Kimura, Mitsutoshi; Ando, Masahiko; Kinoshita, Osamu; Yamauchi, Haruo; Ono, Minoru] Univ Tokyo, Grad Sch Med, Dept Cardiac Surg, Tokyo, Japan.
C3 University of Tokyo; University of Tokyo; University of Tokyo;
   University of Tokyo; University of Tokyo
RP Tsuji, M (通讯作者)，Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Hongo 7-3-1, Tokyo 1138655, Japan.
EM mtsuji-cib@umin.ac.jp
RI Amiya, Eisuke/O-4981-2019; Komuro, Issei/JXL-2876-2024
OI Kimura, Mitsutoshi/0009-0007-9071-4400; 
FU Grants-in-Aid for Scientific Research [21K08047] Funding Source: KAKEN
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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NR 35
TC 4
Z9 4
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-564X
EI 1525-1594
J9 ARTIF ORGANS
JI Artif. Organs
PD MAR
PY 2023
VL 47
IS 3
BP 566
EP 573
DI 10.1111/aor.14440
EA NOV 2022
PG 8
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA Q5SQ5
UT WOS:000881945400001
PM 36300650
DA 2026-07-24
ER
PT J
AU Tang, NI
   Li, H
   Chow, Y
   Blake, W
AF Tang, Nicholas
   Li, Henry
   Chow, Yvonne
   Blake, William
TI Non-operative adjuncts for the prevention of mastectomy skin flap
   necrosis: a systematic review and meta-analysis
SO ANZ JOURNAL OF SURGERY
LA English
DT Review
DE breast cancer; breast reconstruction; flaps; mastectomy; negative
   pressure wound therapy
ID INCISION MANAGEMENT-SYSTEM; SPARING MASTECTOMY; BREAST RECONSTRUCTION;
   NITROGLYCERIN OINTMENT; DIMETHYL-SULFOXIDE; COMPLICATIONS; ISCHEMIA;
   SURVIVAL; RISK
AB Background Native skin flap necrosis is a potentially devastating complication following skin-sparing or nipple-sparing mastectomy with a reported incidence of as high as 30%. Treatment depends on the depth and extent of tissue necrosis and can range from dressings to surgical debridement and further reconstruction. This can have implications on patient physical and psychological wellbeing as well as cost of treatment. This study aims to identify and appraise cost-effective non-surgical adjuncts for the prevention of native skin flap necrosis. Methods A systematic review was performed using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and structured around existing recommended guidelines. A search of MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature and ClinicalTrials.gov was performed with the medical subject headings 'mastectomy' and 'flap necrosis'. After exclusion, 12 articles were selected for review and analysed. Results A total of 8439 mastectomies were performed on 7895 patients. Preventative non-surgical adjuncts that demonstrated statistically significant reduction in mastectomy flap necrosis included topical nitroglycerin ointment (P = 0.000), closed-Incision negative pressure wound therapy (P = 0.000), topical dimethylsulfoxide ointment (P = 0.03), oral cilostazol (P = 0.032), and local heat pre-conditioning (P = 0.047). Conclusions This study identifies multiple adjuncts that may aid in preventing mastectomy skin flap necrosis, especially in high-risk patients. Further studies could aim to define standardized protocols and compare the various adjuncts in different circumstances.
C1 [Tang, Nicholas; Li, Henry; Chow, Yvonne; Blake, William] Monash Hlth, Dandenong Hosp, Dept Plast & Reconstruct Surg, Melbourne, Vic, Australia.
C3 Monash Health; Dandenong Hospital
RP Tang, NI (通讯作者)，Monash Hlth, Dandenong Hosp, 135 David St, Melbourne, Vic 3175, Australia.
EM nsjtang@gmail.com
OI Blake, William/0009-0000-1533-1572
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NR 57
TC 14
Z9 15
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD JAN
PY 2023
VL 93
IS 1-2
BP 65
EP 75
DI 10.1111/ans.18146
EA NOV 2022
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9A2CO
UT WOS:000882871700001
PM 36373495
DA 2026-07-24
ER
PT J
AU Ma, XW
   Wang, ZP
   Wang, JC
AF Ma, Xiaowei
   Wang, Zongpu
   Wang, Jianchuan
TI Clinical analysis of accelerated rehabilitation surgery for Gustilo type
   IIIA/B open tibio fibular fracture
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE ERAS; Open fracture of the tibia and fibula; Soft-tissue defect; Muscle
   flap transfer
ID EXTERNAL FIXATION; ENHANCED RECOVERY; RECONSTRUCTION; CONVERSION;
   INFECTION; SHAFT; BONE; NAIL
AB Purpose To investigate the clinical efficacy of accelerated rehabilitation surgery for the treatment of Gustilo type IIIA/B open tibiofibular fracture with emergency stage I debridement, internal fracture fixation, bone grafting, coverage of the wound surface with a muscle flap combined with vacuum sealing drainage (VSD), and internal and lateral leg reduction. Methods A retrospective analysis was performed on the clinical data of 15 patients with Gustilo type IIIA/B open tibiofibular fracture who were admitted to the Affiliated Zhongshan Hospital of Dalian University from January 2015 to December 2018. There were 12 males and 3 females. The patients ranged in age from 20 to 62 years, with an average of 39.5 years. After admission, the patients underwent stage I emergency debridement (including exploration and repair of nerves and tendons), open reduction and internal fixation of the tibia and fibula, iliac bone grafting, muscle flap and VSD coverage of the bone defect, complete tensioning of the calf inside and outside, tibia-sparing incision before healing, and stage II free skin grafting. Patients were followed up periodically to observe muscle flap survival, fracture healing time, length of hospitalization, wound healing time, delayed union, bone nonunion, osteomyelitis and other complications. At the last follow-up, the Johner-Wruhs criteria were used to evaluate the rate of good functional recovery from tibial shaft fracture, fracture healing quality was evaluated by the Merchant score, and limb function was evaluated by the LEFS. Results All 15 cases were followed up for 12-32 months, with an average of 22.8 months. All the fractures healed; the range of healing time was 14-30 weeks (mean 18.5 weeks). The length of hospitalization was 25.1 +/- 7.6 days, and wound healing took 12.2 +/- 2.0 days. None of the patients had complications such as osteomyelitis infection. When the Johner-Wruhs evaluation criteria for functional recovery from tibial shaft fracture were applied at the last follow-up, the outcomes were as follows: excellent in 13 cases, good in 1 case and fair in 1 case, for an excellent and good rate of 93.3%. When fracture healing was evaluated according to the Merchant scoring standard, the outcomes were as follows: excellent in 12 cases, good in 1 case, fair in 1 case, and poor in 1 case, for an excellent and good rate of 86.7%. The mean LEFS score of the affected limb at the last follow-up was 70 (59-80). Conclusion For Gustilo type IIIA/B open tibiofibular fractures, emergency stage I debridement, internal fixation of the fracture, bone grafting, coverage of the wound with a muscle flap, complete tensioning of the calf inside and outside, and application of VSD can improve the repair of leg soft-tissue defects, shorten hospitalization time, promote fracture healing, and effectively reduce infection and complications related to bone exposure. More importantly, this treatment protocol provides effective wound repair, guarantees the recovery of limb function, significantly speeds up recovery, and improve patients' quality of life.
C1 [Ma, Xiaowei; Wang, Zongpu; Wang, Jianchuan] Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Peoples R China.
C3 Dalian University
RP Wang, JC (通讯作者)，Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Peoples R China.
EM 422186196@qq.com
CR Al-Hourani K, 2021, INJURY, V52, P378, DOI 10.1016/j.injury.2021.01.021
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NR 28
TC 4
Z9 5
U1 0
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD DEC
PY 2023
VL 49
IS 6
SI SI
BP 2355
EP 2362
DI 10.1007/s00068-022-02164-x
EA NOV 2022
PG 8
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA CS9L3
UT WOS:000884081400002
PM 36370184
DA 2026-07-24
ER
PT J
AU Xue, X
   Bian, YL
   Yang, M
   Wei, W
   Meng, LM
   Zhang, QF
   Tao, JG
AF Xue, Xin
   Bian, Yuling
   Yang, Meng
   Wei, Wei
   Meng, Lingmin
   Zhang, Qingfu
   Tao, Jianguang
TI Evaluation of injectable platelet-rich fibrin produced by a simple
   twice-centrifugation method combined with vacuum sealing drainage
   technology in the treatment of chronic refractory wounds
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Article
DE injectable platelet-rich fibrin; vacuum sealing drainage; chronic
   refractory wounds; wound inflammation; treatment
AB Objective: To evaluate the effects of injectable platelet-rich fibrin (i-PRF) produced by a simple twice-centrifugation method combined with vacuum sealing drainage on wound inflammation and scar formation in chronic refractory wounds (CRW).Methods: A total of sixty-eight patients with CRW who were admitted to our hospital were enrolled in this study. They were then randomly divided into the study group (n = 34) with being treated using negative pressure sealing and drainage technology, and the control group (n = 34) with being treated using injectable platelet-rich fibrin in conjunction with negative pressure sealing and drainage technology. The following were the primary outcomes: scar conditions at 1 and 3 months after the wound was fully healed, wound healing time, hospitalization time, wound healing rate, incidence of adverse reactions, serum inflammatory indices, and pain levels were assessed 1 day before treatment and 14 days after treatment. The secondary outcomes were determined by comparing the proportion of positive bacterial cultures in the two groups on the day before therapy, as well as on the seventh and fourteenth days after treatment.Results: The wound healing time and hospital stay in the study group were significantly lower than that in the control group (all p < 0.001). The wound healing rate of the study group was significantly higher than that of the control group on the 14th day and 28th day after treatment (all p < 0.001). On the 14th day after treatment, the levels of WBC, CRP, and IL-6 in the study group were lower than those in the control group (all p < 0.001). The positive rate of bacterial culture in the study group was significantly lower than that in the control group on the 7th and 14th day after treatment (all p < 0.05). At 1 month and 3 months after treatment, the VSS score in the study group was lower than that in the control group (all p < 0.001). The total defect rate of the study group was also significantly lower than that of the control group (5.88% vs. 29.41%, p = 0.011).Conclusion: The i-PRF produced by simple twice-centrifugation method combined with VSD could reduce wound inflammation and improve scar formation in patients with CRW.
C1 [Xue, Xin; Yang, Meng; Wei, Wei; Meng, Lingmin; Zhang, Qingfu] Hebei Med Univ, Hosp 1, Dept Burn & Plast Surg, Shijiazhuang, Peoples R China.
   [Bian, Yuling] Hebei Water Conservancy Hosp, Dept Obstet & Gynecol, Shijiazhuang, Peoples R China.
   [Tao, Jianguang] Handan Cent Hosp, Dept Burn & Plast Surg, Handan, Peoples R China.
C3 Hebei Medical University
RP Tao, JG (通讯作者)，Handan Cent Hosp, Dept Burn & Plast Surg, Handan, Peoples R China.
EM 24220038677@qq.com
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   Wang L, 2019, Zhonghua Shao Shang Za Zhi, V35, P18, DOI 10.3760/cma.j.issn.1009-2587.2019.01.005
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   Zhang W, 2020, Zhonghua Yi Xue Za Zhi, V100, P291, DOI 10.3760/cma.j.issn.0376-2491.2020.04.010
NR 31
TC 10
Z9 12
U1 0
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD OCT 28
PY 2022
VL 10
AR 979834
DI 10.3389/fbioe.2022.979834
PG 10
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 6F9MS
UT WOS:000884385200001
PM 36394016
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jiao, HB
   Tian, T
   Chen, CJ
   Ji, G
AF Jiao, Hongbo
   Tian, Tian
   Chen, Chuanjun
   Ji, Geng
TI Effect of vacuum sealing drainage plus skin grafting on deep burns and
   analysis of risk factors for postoperative infection
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Vacuum sealing drainage (VSD); skin grafting; deep burn; wound repair;
   postoperative infection; risk factors
ID NOSOCOMIAL INFECTION; FOOT
AB Objective: To analyze the effect of vacuum sealing drainage (VSD) plus skin grafting on deep burns and the risk factors of postoperative infection. Methods: A retrospective analysis was conducted on 124 patients with deep burns who were admitted to the Taizhou People's Hospital from February 2019 to February 2021. The 55 patients who underwent traditional dressing change therapy plus second-stage skin grafting became the control group. The remaining 69 patients treated with first stage VSD plus second-stage skin grafting became the observation group. Wound healing time, hospital stay, postoperative infection, wound closure success rate, pain degree, and scar hyperplasia were recorded and compared between the two groups. Logistic regression was used to analyze the risk factors of postoperative infection in patients. Results: Compared with the control group, the observation group had a shorter time of wound healing and hospital stay, lower postoperative wound infection rate and lung infection rate, higher success rate of wound closure, lower pain degree scores on the 7th day after the operation, and less scar hyperplasia (all P < 0.05). Logistic regression analysis revealed that burn degree, treatment plan, proportion of burn area, and wound healing time were the factors affecting postoperative infection in patients. Conclusion: VSD plus skin grafting have significant effects on deep burns. This combined treatment reduced the occurrence of the wound infection, relieved pain, shortened the healing time and hospitalization time, and reduced the proliferation of scars in the later stage.
C1 [Jiao, Hongbo; Tian, Tian; Chen, Chuanjun; Ji, Geng] Taizhou Peoples Hosp, Burn & Plast Surg, 366 Taihu Rd, Taizhou 225300, Jiangsu, Peoples R China.
RP Ji, G (通讯作者)，Taizhou Peoples Hosp, Burn & Plast Surg, 366 Taihu Rd, Taizhou 225300, Jiangsu, Peoples R China.
EM jigeng197805@163.com
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NR 27
TC 2
Z9 5
U1 0
U2 8
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2022
VL 14
IS 10
BP 7477
EP 7486
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 6F9YC
UT WOS:000884416000009
PM 36398255
DA 2026-07-24
ER
PT J
AU Cui, HC
   Chang, ZQ
   Yu, XC
AF Cui, Haocheng
   Chang, Zhengqi
   Yu, Xiuchun
TI Treatment of lumbar brucella spondylitis with negative pressure wound
   therapy via extreme lateral approach: A case report
SO FRONTIERS IN SURGERY
LA English
DT Article
DE brucella spondylitis; vacuum sealing drainage (VSD); negative pressure
   wound therapy (NPWT); extreme lateral interbody fusion (XLIF); spinal
   infection
ID VACUUM SEALING DRAINAGE
AB Brucella spondylitis (BS) is a specific spinal infection. Surgical treatment is required for Brucella spondylitis that has caused neurological symptoms in the lower extremities and developed an intraspinal abscess. The main purpose of surgery is to remove the lesion and restore the stability of the spine. However, both the anterior approach and the posterior approach cannot completely remove the lesions, resulting in a low cure rate and a certain recurrence rate. Although anterior or posterior debridement is more thorough, it is unbearable for some patients with poor general condition. In this study, for the first time, a negative pressure wound therapy (NPWT) device was introduced into the intervertebral space through the extreme lateral approach to treat a patient with Brucella spondylitis. We summarize the treatment process, and discuss the feasibility and effectiveness of this surgical approach through 1-year follow-up.
C1 [Cui, Haocheng; Chang, Zhengqi; Yu, Xiuchun] 960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
RP Chang, ZQ; Yu, XC (通讯作者)，960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
EM 26766771@qq.com; 13969132190@163.com
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NR 15
TC 2
Z9 2
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD OCT 26
PY 2022
VL 9
AR 974931
DI 10.3389/fsurg.2022.974931
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6G9XK
UT WOS:000885104700001
PM 36386539
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Roberson, JL
   Butt, Z
   Florez-Pollack, S
   Morgan, E
   Rosenbach, M
   Braslow, BM
   Yelon, JA
AF Roberson, Jeffrey L.
   Butt, Zoya
   Florez-Pollack, Stephanie
   Morgan, Eric
   Rosenbach, Misha
   Braslow, Benjamin M.
   Yelon, Jay A.
TI An Intensive Multidisciplinary Approach in Management of Extensive
   Nonuremic Calciphylaxis of the Bilateral Lower Extremities with
   Angioinvasive Fungus and Mold
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID HYPOCHLOROUS ACID; RISK-FACTORS; COHORT
AB Management of infected wounds related to calciphylaxis poses a significant clinical challenge with high morbidity and mortality. Given no definitive management guidelines exist specific to nonuremic calciphylaxis, multiple modalities including sodium thiosulfate, antibiotics, hyperbaric oxygen therapy, and surgical debridement with wound care must be considered. When occurring over a large surface area, standard daily dressing changes are especially labor intensive, inefficient, and ineffective. Negative pressure wound therapy with instillation and dwell time offers broad wound coverage with ongoing therapeutic benefit. We present the case of a previously healthy 19-year-old woman who was transferred for tertiary level care of extensive nonuremic calciphylaxis wounds of the bilateral lower extremities complicated by angioinvasive coinfection with fungus and mold that was managed with a multidisciplinary approach of intensive medical management, aggressive surgical debridement, and negative pressure wound therapy with instillation of hypochlorous acid solution. Ultimately, she achieved full granulation and wound coverage with skin grafting. Large area, infected wounds related to nonuremic calciphylaxis can be successfully managed with multidisciplinary medical management, aggressive surgical debridement, and negative pressure wound therapy that can instill and dwell hypochlorous acid solution.
C1 [Roberson, Jeffrey L.; Butt, Zoya] Hosp Univ Penn, Dept Surg, Philadelphia, PA USA.
   [Florez-Pollack, Stephanie; Rosenbach, Misha] Hosp Univ Penn, Dept Dermatol, Philadelphia, PA USA.
   [Morgan, Eric] Hosp Univ Penn, Dept Pathol, Philadelphia, PA USA.
   [Morgan, Eric] Hosp Univ Penn, Lab Med, Philadelphia, PA USA.
   [Braslow, Benjamin M.; Yelon, Jay A.] Hosp Univ Penn, Div Trauma, Surg Crit Care & Emergency Surg, Dept Surg, Philadelphia, PA USA.
   [Roberson, Jeffrey L.] Hosp Univ Penn, Dept Surg, 3400 Spruce St,4 Maloney, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of Pennsylvania; University of Pennsylvania;
   University of Pennsylvania
RP Roberson, JL (通讯作者)，Hosp Univ Penn, Dept Surg, 3400 Spruce St,4 Maloney, Philadelphia, PA 19104 USA.
EM jeffrey.roberson@pennmedicine.upenn.edu
RI Morgan, Eric/NEU-1212-2025
OI Florez-Pollack, Stephanie/0000-0002-5959-0856; Yelon,
   Jay/0000-0001-7980-8042
CR Barbosa Manuel Martins, 2019, Eur J Case Rep Intern Med, V6, P001078, DOI [10.12890/2019_001078, 10.12890/2019_001078]
   Chen TY, 2017, AM J DERMATOPATH, V39, P795, DOI 10.1097/DAD.0000000000000824
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   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
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   Roy R, 2011, ENDOCR PRACT, V17, P54, DOI 10.4158/EP10349.RA
   Sakarya S, 2014, WOUNDS, V26, P342
   Solanky D, 2015, WOUNDS, V27, P302
   Tangkijngamvong Natsinee, 2021, J Clin Aesthet Dermatol, V14, P48
   Weenig RH, 2007, J AM ACAD DERMATOL, V56, P569, DOI 10.1016/j.jaad.2006.08.065
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   Yu WYH, 2017, JAMA DERMATOL, V153, P309, DOI 10.1001/jamadermatol.2016.4821
NR 21
TC 2
Z9 3
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN 5
PY 2023
VL 44
IS 1
BP 218
EP 221
DI 10.1093/jbcr/irac158
EA OCT 2022
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 7S7CQ
UT WOS:000886364500001
PM 36269818
DA 2026-07-24
ER
PT J
AU Qian, H
   Lei, T
   Hu, YH
AF Qian, Hu
   Lei, Ting
   Hu, Yihe
TI Negative pressure wound therapy versus gauze dressings in managing open
   fracture wound of lower limbs: A meta-analysis of randomized controlled
   trials
SO FOOT AND ANKLE SURGERY
LA English
DT Article
DE Open fracture; Negative pressure wound therapy; Standard gauze dressing;
   Meta-analysis; Randomized controlled trials
ID NPWT; INFECTION; TRAUMA
AB Background: The superiority of negative pressure wound therapy (NPWT) to standard gauze dressings for managing open fractures of the lower limbs remains controversial. This study aimed to comprehensively compare their clinical efficacy through a meta-analysis using randomized controlled trials (RCTs) alone. We hypothesized that NPWT would be more superior against infections.Methods: A literature search was implemented in various databases, including PubMed, Web of Science, Medline, Clinicaltrial.gov, and Cochrane Library, etc, to screen eligible RCTs. All included RCTs were eval-uated for risk of bias using the Cochrane Collaboration tool. In accordance with the heterogeneity assess-ment, a fixed-effect or random-effect model was chosen for the data analysis.Results: Ten RCTs, including 2780 patients, were eligible for the meta-analysis. We found that patients in the NPWT group showed a lower overall infection rate (MD=0.70, 95% CI: 0.54-0.90, P = 0.005), acute wound infection rate (MD = 0.35, 95% CI: 0.16-0.77, P = 0.009), and shorter hospital stay (MD = 24.00, 95% CI: 6.82-84.46, P < 0.00001) compared with the control group. The NPWT group showed a higher proportion of patients with wound coverage than the control group. No significant difference was found between the two groups in terms of function score and other complications, including deep infection rate, amputation, and bone nonunion.Conclusions: From the pooled results, we suggest that NPWT may be superior than traditional gauze dressings for managing open fractures of the lower limbs.(c) 2022 Published by Elsevier Ltd on behalf of European Foot and Ankle Society.
C1 [Qian, Hu; Lei, Ting; Hu, Yihe] Cent South Univ, Xiangya Hosp, Dept Orthopead Surg, Changsha, Peoples R China.
   [Hu, Yihe] Zhejiang Univ, Affliated Hosp 1, Coll Med, Dept Orthoped Surg, Hangzhou, Peoples R China.
   [Hu, Yihe] Hunan Engn Res Ctr Biomed Met & Ceram Implants, Changsha, Peoples R China.
   [Hu, Yihe] Cent South Univ, Xiangya Hosp, Dept Orthoped Surg, 87 Xiangya Rd, Changsha 410008, Peoples R China.
C3 Central South University; Zhejiang University; Central South University
RP Lei, T; Hu, YH (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Orthopead Surg, Changsha, Peoples R China.; Hu, YH (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Orthoped Surg, 87 Xiangya Rd, Changsha 410008, Peoples R China.
EM leiting19950415@gmail.com; csuyihehu@gmail.com
RI Lei, Ting/AAB-4274-2022
FU National Natural Science Foundation of China;  [81873988]
FX Funding This study was supported by the National Natural Science
   Foundation of China (Grant Nos. 81873988) .
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NR 22
TC 10
Z9 13
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1268-7731
EI 1460-9584
J9 FOOT ANKLE SURG
JI Foot Ankle Surg.
PD OCT
PY 2022
VL 28
IS 7
BP 1120
EP 1128
DI 10.1016/j.fas.2022.03.012
EA SEP 2022
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 6J0RB
UT WOS:000886535900006
PM 35450789
DA 2026-07-24
ER
PT J
AU Cholok, D
   Saberski, E
   Lowenberg, DW
AF Cholok, David
   Saberski, Ean
   Lowenberg, David W.
TI Approach to Complex Lower Extremity Reconstruction
SO SEMINARS IN PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; fractures; lower extremity
ID FREE-TISSUE TRANSFER; OPEN TIBIAL FRACTURES; MICROSURGICAL
   RECONSTRUCTION; FLAP COVERAGE; MUSCLE FLAP; MANAGEMENT; OUTCOMES;
   TRAUMA; COMPLICATIONS; SALVAGE
AB Composite injuries to the lower extremity from etiologies including trauma and infection present a complex dilemma for the reconstructive surgeon, and require multidisciplinary collaboration amongst plastic, vascular, and orthopaedic surgical specialties. Here we present our algorithm for lower-extremity reconstructive management, refined over the last decades to provide an optimized outcome for our patients. Reconstruction is predicated on the establishment of a clean and living wound, where quality of the wound-bed is prioritized over timing to soft-tissue coverage. Once established, soft-tissues and fractures are provisionally stabilized; our preference for definitive coverage is for microvascular free-tissue, due to the paucity of healthy soft-tissue available at the injury, and ability to avoid the zone of injury for microvascular anastomosis. Finally, definitive bony reconstruction is dictated by the length and location of long-bone defect, with a preference to utilize bone transport for defects longer than 5 cm.
C1 [Cholok, David] Stanford Univ, Div Plast & Reconstruct Surg, Sch Med, 770 Welch Rd,Suite 400, Palo Alto, CA 94304 USA.
   [Saberski, Ean] Walter Reed Natl Mil Med Ctr, Dept Gen Surg, Bethesda, MD USA.
   [Lowenberg, David W.] Stanford Univ, Dept Orthoped Surg, Sch Med, Palo Alto, CA 94304 USA.
C3 Stanford University; Walter Reed National Military Medical Center;
   Stanford University
RP Cholok, D (通讯作者)，Stanford Univ, Div Plast & Reconstruct Surg, Sch Med, 770 Welch Rd,Suite 400, Palo Alto, CA 94304 USA.
EM dcholok@stanford.edu
OI Lowenberg, David/0000-0001-6416-1063
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NR 55
TC 8
Z9 8
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1535-2188
EI 1536-0067
J9 SEMIN PLAST SURG
JI Semin. Plast. Surg.
PD NOV
PY 2022
VL 36
IS 04
BP 233
EP 242
DI 10.1055/s-0042-1758205
EA NOV 2022
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 7D8XU
UT WOS:000886609700002
PM 36561427
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Zhou, B
   Qin, HT
   Huang, YC
   Wang, QZ
   Zhang, J
   Xiao, YF
   Peng, YB
   Yu, F
AF Zhou, Bo
   Qin, Haotian
   Huang, Yicong
   Wang, Quanzhen
   Zhang, Jian
   Xiao, Yingfeng
   Peng, Yanbin
   Yu, Fei
TI Atrophie blanche complicated with lower limb infection and maggot
   growth: A case report
SO FRONTIERS IN SURGERY
LA English
DT Article
DE atrophie blanche; maggots; skin grafting; suppurative infection; surgery
ID LIVEDOID VASCULOPATHY; MYIASIS
AB BackgroundAtrophie blanche (AB) is a thrombotic vascular disease, also known as venous vasculitis or segmental hyaline vasculitis, characterized by chronic recurring painful ulcers on the lower legs, especially the ankles. AB is a clinically rare condition, affecting 1%-5% of the population, specifically middle-aged women with an average age of 45 years, and cases of AB in children are rare. Following recovery, ivory-white atrophy spots accompanied by pigmentation and telangiectasia remain in patients. One of the complications of AB is the parasitic growth of microorganisms infecting the ischemic soft tissue undergoing necrosis in the lower limbs. Furthermore, although infection combined with microbial parasitism is a type of surgical site infection, myiasis is particularly rare, which may warrant limb amputation or may even be life-threatening. Understanding the complications of AB may help in early and timely surgical debridement as well as wound repair. Summarizing the knowledge and treatment strategies of AB and formulating clinical strategies and guidelines for AB management with insights from relevant cases are important. Case summaryA 59-year-old woman was hospitalized due to repeated ulceration of the skin of the right lower leg for 3 years, aggravation, and maggot growth for 3 days. In the previous 3 years, the skin and soft tissue of the right calf had become ischemic, necrotic, and infected, but the patient did not seek any medical treatment. Subsequently, 2 years ago, she was diagnosed with AB at the dermatology department of our hospital. After hormone treatment, her right leg improved. However, 1 year ago, the skin and soft tissue of the right leg again became ischemic, necrotic, and infected. This time, the patient did not seek medical treatment and applied musk on her wound. The wound deepened, resulting in the exposure of the tendon and some bones. In addition, a large number of maggots and microorganisms grew in and infested the wound for 3 days before the patient came to our department for treatment. Debridement of the necrotizing infected site on the right lower leg combined with negative pressure vacuum sealing drainage were performed twice within 16 days after admission. Simultaneously, antibiotics were given systemically. On the 17th day after admission, the wound appeared clean, myiasis had resolved, and the growth and coverage of the granulation tissue on the wound were satisfactory. Subsequently, debridement of the infected site on the right leg, removal of skin of the right thigh, and autologous free skin grafting were performed. After 10 days, the wound was clean, all skin grafts had survived, and wound repair was satisfactory. Finally, the patient was discharged after 38 days of hospitalization. ConclusionAlthough AB is rare, leukodystrophy requires specialized treatment and regular follow-up. If lower limb infection and maggot growth occur simultaneously, self-treatment should be avoided and medical attention must be sought immediately. Early implementation of wound debridement and anti-infective treatment combined with wound repair, which should be performed after cleaning the wound, is advised.
C1 [Zhou, Bo; Wang, Quanzhen; Zhang, Jian; Xiao, Yingfeng; Peng, Yanbin] Peking Univ, Shenzhen Hosp, Dept Hand & Microsurg, Shenzhen, Peoples R China.
   [Qin, Haotian; Yu, Fei] Peking Univ, Shenzhen Hosp, Dept Bone & Joint Surg, Shenzhen, Peoples R China.
   [Qin, Haotian; Yu, Fei] Peking Univ, Shenzhen Hosp, Natl & Local Joint Engn Res Ctr Orthopaed Biomat, Shenzhen, Peoples R China.
   [Huang, Yicong] Southern Med Univ, Dongguan Peoples Hosp, Dept Orthoped Surg, Dongguan, Peoples R China.
C3 Peking University; Peking University; Peking University; Southern
   Medical University - China
RP Peng, YB (通讯作者)，Peking Univ, Shenzhen Hosp, Dept Hand & Microsurg, Shenzhen, Peoples R China.; Yu, F (通讯作者)，Peking Univ, Shenzhen Hosp, Dept Bone & Joint Surg, Shenzhen, Peoples R China.; Yu, F (通讯作者)，Peking Univ, Shenzhen Hosp, Natl & Local Joint Engn Res Ctr Orthopaed Biomat, Shenzhen, Peoples R China.
EM yufei89@pku.edu.cn; plybl@163.com
RI Yu, Fei/KIJ-8453-2024
OI Yu, Fei/0000-0002-5941-6452
FU National Natural Science Foundation of China [82102568, 82172432,
   82001319, 82102076]; National & Local Joint Engineering Research Center
   of Orthopaedic Biomaterials [XMHT20190204007]; Shenzhen High-level
   Hospital Construction Fund; Shenzhen Key Medical Discipline Construction
   Fund [SZXK023]; Shenzhen "San-Ming" Project of Medicine [SZSM201612092];
   Research and Development Projects of Shenzhen [Z2021N054]; Guangdong
   Basic and Applied Basic Research Foundation [2021A1515012586]; Bethune
   Charitable Foundation; CSPC Osteoporosis Research Foundation Project
   [G-X-2020-1107-21]; Scientific Research Foundation of PEKING UNIVERSITY
   SHENZHEN HOSPITAL [KYQD2021099]
FX This research was continuously funded by the National Natural Science
   Foundation of China (No. 82102568, 82172432, 82001319, and 82102076);
   the National & Local Joint Engineering Research Center of Orthopaedic
   Biomaterials (XMHT20190204007); Shenzhen High-level Hospital
   Construction Fund, Shenzhen Key Medical Discipline Construction Fund
   (No. SZXK023); Shenzhen "San-Ming" Project of Medicine (No.
   SZSM201612092); Research and Development Projects of Shenzhen (No.
   Z2021N054); Guangdong Basic and Applied Basic Research Foundation (No.
   2021A1515012586); Bethune Charitable Foundation and CSPC Osteoporosis
   Research Foundation Project (No. G-X-2020-1107-21); and Scientific
   Research Foundation of PEKING UNIVERSITY SHENZHEN HOSPITAL (No.
   KYQD2021099).
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NR 18
TC 1
Z9 1
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD NOV 7
PY 2022
VL 9
AR 941568
DI 10.3389/fsurg.2022.941568
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6L9TD
UT WOS:000888520800001
PM 36420413
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Nakagawa, Y
   Uchida, H
   Hinoki, A
   Shirota, C
   Sumida, W
   Makita, S
   Amano, H
   Okamoto, M
   Takimoto, A
   Ogata, S
   Takada, S
   Kato, D
   Gohda, Y
AF Nakagawa, Yoichi
   Uchida, Hiroo
   Hinoki, Akinari
   Shirota, Chiyoe
   Sumida, Wataru
   Makita, Satoshi
   Amano, Hizuru
   Okamoto, Masamune
   Takimoto, Aitaro
   Ogata, Seiya
   Takada, Shunya
   Kato, Daiki
   Gohda, Yousuke
TI Combined negative pressure wound therapy with irrigation and dwell time
   and artificial dermis prevents infection and promotes granulation
   formation in a ruptured giant omphalocele: a case report
SO BMC PEDIATRICS
LA English
DT Article
DE Negative pressure wound therapy; Negative pressure wound therapy with
   irrigation and dwell time; Omphalocele
ID VACUUM-ASSISTED CLOSURE; TISSUE DEFECTS; INSTILLATION; MANAGEMENT;
   MORTALITY
AB Background Omphalocele is a congenital abdominal wall defect of the umbilical cord insertion site. A giant omphalocele, with a fascial defect > 5 cm in diameter and/or containing > 50% of the liver within the hernia sac, can be challenging for pediatric surgeons. Recently, negative pressure wound therapy has been reported as an effective management for giant omphaloceles; however, it is not recommended for an infected wound with necrotic tissue as it may exacerbate infection. We adopted negative pressure wound therapy with irrigation and dwell time (NPWTi-d) for a case of a ruptured giant omphalocele. Artificial membranes, followed by artificial dermis, were used to promote fibrous capsule formation, and then NPWTi-d was used to promote granulation while controlling infection. However, studies have not been conducted regarding NPWTi-d for ruptured giant omphaloceles; hence, we present our treatment experience with NPWTi-d for a giant omphalocele. Case presentation The patient was a boy born at 38 weeks and 3 days of gestation, weighing 1896 g. He was diagnosed with a ruptured giant omphalocele with a total liver and intestine defect hole of 10 cm x 10 cm. The patient underwent silo placement using an artificial mesh, followed by plicating the artificial mesh at 4 days of age. The herniated viscera were gradually reduced into the abdominal cavity; however, the defect size was still large. Hence, a collagen-based artificial dermis was patched on the defect hole. After creating a fresh and smooth granulated tissue, NPWTi-d was applied at 33 days of age to promote granulation and control infection. We used the 3 M (TM) V.A.C.(R) Ulta Therapy Unit with 3 M (TM) VeraFlo (TM) therapy. NPWTi-d was stopped at 60 days of age when the granulation tissue was well formed including at the artificial dermis site. The wound was managed with prostandin ointment and appropriate debridement, resulting in complete epithelialization at 5 months of age. Conclusions Artificial membranes followed by artificial dermis were used to promote a fibrous capsule and artificial dermis granulation, which protects against organ damage. NPWTi-d achieved better control of infection and promoted wound healing. NPWTi-d combined with artificial dermis can effectively treat ruptured giant omphaloceles.
C1 [Nakagawa, Yoichi; Uchida, Hiroo; Shirota, Chiyoe; Sumida, Wataru; Makita, Satoshi; Amano, Hizuru; Okamoto, Masamune; Takimoto, Aitaro; Ogata, Seiya; Takada, Shunya; Kato, Daiki; Gohda, Yousuke] Nagoya Univ, Dept Pediat Surg, Grad Sch Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
   [Hinoki, Akinari] Nagoya Univ, Grad Sch Med, Dept Rare Intractable Canc Anal Res, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
C3 Nagoya University; Nagoya University
RP Uchida, H (通讯作者)，Nagoya Univ, Dept Pediat Surg, Grad Sch Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
EM hiro2013@med.nagoya-u.ac.jp
RI ; UCHIDA, Hiroo/E-4437-2015; Nakagawa, Yoichi/HKF-0307-2023; Hinoki,
   Akinari/Q-1122-2015; Takimoto, Aitaro/LTE-5262-2024; Sumida,
   Wataru/QLU-7315-2026
OI Okamoto, Masamune/0009-0008-8401-1191; UCHIDA,
   Hiroo/0000-0002-1818-6697; Nakagawa, Yoichi/0000-0003-1570-8661; 
CR Adetayo OA, 2012, ANN PLAS SURG, V69, P104, DOI 10.1097/SAP.0b013e31822128f5
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NR 30
TC 6
Z9 6
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD NOV 26
PY 2022
VL 22
IS 1
AR 680
DI 10.1186/s12887-022-03755-8
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 6M3ZK
UT WOS:000888809300003
PM 36435753
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kim, MJ
   Jeong, YS
   Kim, TW
   Park, DH
   Lee, IJ
AF Kim, Min Ji
   Jeong, Yon Soo
   Kim, Tae Wook
   Park, Dong Ha
   Lee, Il Jae
TI The clinical efficacy of pure-grind acellular dermal matrix without
   gelatin in lower extremity skin defect treatment: A prospective
   randomized study
SO FRONTIERS IN MATERIALS
LA English
DT Article
DE acellular dermal matrix; skin defect; leg ulcer; wound healing; wounds
   and injuries
ID CROSS-LINKING; COVERAGE; SCAFFOLD; PASTE
AB Background: Acellular dermal matrix (ADM) is currently considered as a replacement for lost extracellular matrix. Trials have been conducted on dressing materials with high contents of ADM without any impurities, such as gelatin, which only undergo the grinding process. In this study, we aimed to investigate the clinical application and wound healing effect of pure-grind ADM in lower extremity skin defect treatment. Methods: Patients with skin defects in the lower extremities who did not achieve wound healing within 4 weeks with conservative treatment were enrolled in this study from March 2021 to July 2021. We randomized the patients into two groups. The patients in the experimental group were treated with pure-grind ADM and conventional negative-pressure wound therapy (NPWT), whereas the patients in the control group were only treated with NPWT. Every wound was followed-up for 7 weeks, and complete wound healing was confirmed when the skin defect was fully covered with epithelized tissue. Results: A total of 41 patients were enrolled in this study. Complete wound healing was observed in 73.2% of patients, and 26.8% had an unhealed status until the end of the follow-up. The pure-grind ADM did not promote complete healing (p = 0.796) and was not associated with epithelization time but promoted the velocity of epithelization (experimental 5.58 vs. 3.50 cm(2)/day, p = 0.020). Considering the time of healing, the decrease in wound depth was more extensive (p = 0.021), the speed of granulation tissue formation was higher, and this difference was more evident after 5 weeks of treatment in the experimental group. Conclusion: We demonstrated the clinical efficacy of pure-grind ADM in treatment of lower extremity skin defects. This new type of ADM, without any impurities, is important in wound healing. Its depth filling effect is powerful, and it can promote epithelization velocity and speed of granulation tissue formation.
C1 [Kim, Min Ji; Jeong, Yon Soo; Kim, Tae Wook; Park, Dong Ha; Lee, Il Jae] Ajou Univ, Sch Med, Dept Plast & Reconstruct Surg, Suwon, South Korea.
C3 Ajou University
RP Lee, IJ (通讯作者)，Ajou Univ, Sch Med, Dept Plast & Reconstruct Surg, Suwon, South Korea.
EM i00325@live.co.kr
RI Kim, Taewook/GSD-3143-2022
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health and Welfare, Republic
   of Korea;  [HI20C2140]
FX Funding This research was supported by a grant from the Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute (KHIDI), funded by the Ministry of Health and Welfare,
   Republic of Korea (grant number: HI20C2140).
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NR 32
TC 2
Z9 2
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-8016
J9 FRONT MATER
JI Front. Mater.
PD NOV 10
PY 2022
VL 9
AR 1013245
DI 10.3389/fmats.2022.1013245
PG 10
WC Materials Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA 6N3HE
UT WOS:000889447800001
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Shah, H
   Carstensen, T
   Kmeid, M
   Bialowas, C
AF Shah, Hemali
   Carstensen, Teresa
   Kmeid, Michel
   Bialowas, Christie
TI Cutaneous Blastomycosis Presenting as a Nonhealing Wound in the
   Northeast United States: A Case Report
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE blastomycosis; wound management; spider bite; nonhealing wound
ID THERAPY
AB Primary cutaneous blastomycosis is a rare presentation of infection caused by direct inoculation of a wound. We present a 61-year-old male with an extensive history of wound dehiscence and wound care noncompliance after a bite from a brown recluse spider on the left thigh while on vacation in Cape Cod in September of 2020. After antibiotic therapy and culture, treatment involved debridement, split thickness skin grafting, strict wound vacuum-assisted closure care, and oral itraconazole. This brief demonstrates a case of blastomycosis arising from trauma in a non-endemic region for infection and serves as an example of successful management of the longstanding wound.
C1 [Shah, Hemali] Albany Med Coll, Albany, NY USA.
   [Carstensen, Teresa; Bialowas, Christie] Albany Med Ctr, Div Plast & Reconstruct Surg, Albany, NY USA.
   [Kmeid, Michel] Albany Med Ctr, Dept Pathol, Albany, NY USA.
   [Shah, Hemali] Albany Med Coll, 47 New Scotland Ave, Albany, NY 12208 USA.
C3 Albany Medical College; Albany Medical College; Albany Medical College;
   Albany Medical College
RP Shah, H (通讯作者)，Albany Med Coll, 47 New Scotland Ave, Albany, NY 12208 USA.
EM shahh@amc.edu
RI Shah, Hemali/JAN-4348-2023
OI Shah, Hemali/0000-0002-8407-9339
CR Agha RA, 2016, INT J SURG, V34, P180, DOI 10.1016/j.ijsu.2016.08.014
   Azar MM, 2014, J CLIN MICROBIOL, V52, P1298, DOI 10.1128/JCM.03356-13
   Blume PA, 2010, INT WOUND J, V7, P480, DOI 10.1111/j.1742-481X.2010.00728.x
   Chapman SW, 2008, CLIN INFECT DIS, V46, P1801, DOI 10.1086/588300
   Elmas ÖF, 2020, DERMATOL PRACT CONCE, V10, DOI 10.5826/dpc.1003a54
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   Lectercq A, 2016, ANN DERMATOL VENER, V143, P3, DOI 10.1016/j.annder.2015.06.022
   Mak J, 2018, J CUTAN MED SURG, V22, P519, DOI 10.1177/1203475418760460
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   Ortega-Loayza AG, 2013, AN BRAS DERMATOL, V88, P287, DOI 10.1590/S0365-05962013000200022
   Owen WR, 2012, ADV SKIN WOUND CARE, V25, P321, DOI 10.1097/01.ASW.0000416005.78089.b0
   Tang XH, 2021, MYCOPATHOLOGIA, V186, P449, DOI 10.1007/s11046-021-00551-3
   Wang S, 2015, J AM ACAD DERMATOL, V73, pE169, DOI 10.1016/j.jaad.2015.07.024
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NR 16
TC 2
Z9 2
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2025
VL 24
IS 4
BP 1244
EP 1249
DI 10.1177/15347346221140782
EA NOV 2022
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 9IU0P
UT WOS:000890342900001
PM 36426539
DA 2026-07-24
ER
PT J
AU Nakatsutsumi, K
   Endo, A
   Asano, H
   Shinohara, S
   Kurosaki, R
   Kawashima, S
   Ishii, W
   Nozawa, M
   Tagaya, N
   Otomo, Y
AF Nakatsutsumi, Keita
   Endo, Akira
   Asano, Hiroshi
   Shinohara, Shoichi
   Kurosaki, Ryo
   Kawashima, Shuji
   Ishii, Wataru
   Nozawa, Masashi
   Tagaya, Nobumi
   Otomo, Yasuhiro
TI Prophylactic effect of negative-pressure wound therapy and delayed
   sutures against incisional-surgical site infection after emergency
   laparotomy for colorectal perforation: A multicenter retrospective
   cohort study
SO ANNALS OF GASTROENTEROLOGICAL SURGERY
LA English
DT Article
DE colorectal perforation; emergency surgery; incisional-surgical site
   infection; negative-pressure wound therapy; prophylactic treatment
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL INCISIONS; RISK; SURGERY; IMPACT;
   TRIAL; COSTS
AB Aim: The prophylactic effect of negative-pressure wound therapy against incisional surgical site infection after highly contaminated laparotomies has not been sufficiently explored. This study aimed to evaluate the prophylactic effect of negative-pressure wound therapy against incisional surgical site infection after emergency surgery for colorectal perforation. Methods: This nationwide, multicenter, retrospective cohort study analyzed data from the 48 emergency hospitals certificated by the Japanese Society for Abdominal Emergency Medicine. Patients who underwent an emergency laparotomy for colorectal perforation between April 2015 and March 2020 were included in this study. Outcomes, including the incidence of incisional surgical site infection, were compared between patients who were treated with prophylactic negative-pressure wound therapy and delayed sutures (i.e., negative-pressure wound therapy group) and patients who were treated with regular wound management (i.e., control group) using 1:4 propensity score matching analysis. Results: The negative-pressure wound therapy group comprised 88 patients, whereas the control group consisted of 1535 patients. Of them, 82 propensity score-matched pairs (negative-pressure wound therapy group: 82; control group: 328) were evaluated. The negative-pressure wound therapy group showed a lower incidence of incisional surgical site infection [18 (22.0%) in the negative-pressure wound therapy group and 115 (35.0%) in the control group, odds ratio, 0.52; 95% confidence interval, 0.30 to 0.92; p = 0.026]. Conclusions: The prophylactic use of negative-pressure wound therapy with delayed sutures was associated with a lower incidence of incisional surgical site infection after emergency surgery for colorectal perforation.
C1 [Nakatsutsumi, Keita; Endo, Akira; Otomo, Yasuhiro] Tokyo Med & Dent Univ Hosp, Trauma & Acute Crit Care Ctr, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138510, Japan.
   [Endo, Akira] Tsuchiura Kyodo Gen Hosp, Dept Acute Crit Care Med, Ibaraki, Japan.
   [Asano, Hiroshi] Saitama Med Univ, Dept Gen Surg, Saitama, Japan.
   [Shinohara, Shoichi] Jichi Med Univ, Dept Surg, Div Gastroenterol Gen & Transplant Surg, Shimotsuke, Tochigi, Japan.
   [Kurosaki, Ryo] Japanese Red Cross Maebashi Hosp, Surg Dept, Maebashi, Japan.
   [Kawashima, Shuji] Wakayama Med Univ, Dept Emergency & Crit Care Med, Wakayama, Japan.
   [Ishii, Wataru] Japanese Red Cross Soc, Dept Emergency Med, Kyoto Daini Hosp, Kyoto, Japan.
   [Nozawa, Masashi] Shimada Gen Med Ctr, Dept Surg, Shizuoka, Japan.
   [Tagaya, Nobumi] Itabashi Chuo Med Ctr, Dept Surg, Tokyo, Japan.
   [Otomo, Yasuhiro] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Acute Crit Care & Disaster Med, Tokyo, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Tsuchiura Kyodo Hospital; Saitama Medical University; Jichi Medical
   University; Maebashi Red Cross Hospital; Wakayama Medical University;
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU)
RP Nakatsutsumi, K (通讯作者)，Tokyo Med & Dent Univ Hosp, Trauma & Acute Crit Care Ctr, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138510, Japan.
EM rs.zeyo.1115.accm@tmd.ac.jp
RI Nakatsutsumi, Keita/IUQ-0030-2023
OI Nakatsutsumi, Keita/0000-0001-6140-8761
FU Japanese Society for Abdominal Emergency Medicine
FX the 2019th project study of the Japanese Society for Abdominal Emergency
   Medicine
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NR 29
TC 5
Z9 6
U1 0
U2 2
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 2475-0328
J9 ANN GASTROENT SURG
JI Ann. Gastroent. Surg.
PD MAY
PY 2023
VL 7
IS 3
BP 441
EP 449
DI 10.1002/ags3.12643
EA NOV 2022
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA F2DX9
UT WOS:000891163000001
PM 37152783
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fukui, M
   Matsuoka, Y
   Taketani, S
   Higasa, K
   Hihara, M
   Kuro, A
   Kakudo, N
AF Fukui, Michika
   Matsuoka, Yuki
   Taketani, Shigeru
   Higasa, Koichiro
   Hihara, Masakatsu
   Kuro, Atsuyuki
   Kakudo, Natsuko
TI Accelerated Angiogenesis of Human Umbilical Vein Endothelial Cells Under
   Negative Pressure Was Associated With the Regulation of Gene Expression
   Involved in the Proliferation and Migration
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE angiogenesis; HUVECs; migration; negative-pressure wound therapy;
   proliferation; RNA sequencing
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; MECHANISM; TISSUE
AB Negative pressure has been used as a preferred therapy for wound healing; however, the mechanisms by which negative pressure promotes tissue restoration remain unclear. In the present study, RNA-sequencing analysis was performed to identify differentially expressed genes in human umbilical vein endothelial cells (HUVECs) exposed to negative pressure. Cell viability and DNA synthesis were examined using the cell counting kit-8 assay and bromodeoxyuridine incorporation, respectively. Cell migration was assessed using tube formation, Transwell, and wound healing assays. Activity of the serine/threonine kinase (AKT) signaling pathway was also examined by measuring the levels of phospho-paxicillin, phospho-focal adhesion kinase (p-FAK), and p-AKT1. The exposure of HUVECs to negative pressure enhanced cell proliferation and DNA synthesis. Negative pressure enhanced the migration and invasion of HUVECs, which was accompanied by upregulation of genes involved in angiogenesis, extracellular matrix organization, and cytoskeletal organization. The mRNA levels of growth factors, including placental growth factor and platelet-derived growth factor B, also increased. In addition, phosphorylation of paxicillin, focal adhesion kinase, and AKT increased under negative pressure. Collectively, the findings of this study demonstrated that negative pressure stimulates the angiogenic activity of HUVECs by increasing their proliferation and migration via activation of the AKT signaling pathway.
C1 [Fukui, Michika; Matsuoka, Yuki; Taketani, Shigeru; Hihara, Masakatsu; Kakudo, Natsuko] Kansai Med Univ, Dept Plast & Reconstruct Surg, Hirakata, Japan.
   [Higasa, Koichiro] Kansai Med Univ, Dept Genome Anal, Hirakata, Japan.
   [Kuro, Atsuyuki] Kansai Med Univ, Med Ctr, Dept Plast & Reconstruct Surg, Moriguchi, Osaka, Japan.
   [Fukui, Michika] 2-5-1 Shin-Machi, Hirakata, Osaka 5731010, Japan.
C3 Kansai Medical University; Kansai Medical University; Kansai Medical
   University
RP Fukui, M (通讯作者)，2-5-1 Shin-Machi, Hirakata, Osaka 5731010, Japan.
EM mekam0zunevaneva@gmail.com; matsuoyk@hirakata.kmu.ac.jp;
   atakechan.man9@gmail.com; higasa@genome.med.kyoto-u.ac.jp;
   hiharams@hirakata.kmu.ac.jp; kuroa@hirakata.kmu.ac.jp;
   kakudon@hirakata.kmu.ac.jp
FU Grants-in-Aid for Scientific Research [21H03548, 23K21722] Funding
   Source: KAKEN
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NR 45
TC 2
Z9 2
U1 1
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2022
VL 89
IS 6
BP e51
EP e59
DI 10.1097/SAP.0000000000003298
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6P8JQ
UT WOS:000891172800008
PM 36416703
DA 2026-07-24
ER
PT J
AU Konagaya, K
   Yamamoto, H
   Nishida, T
   Morita, T
   Suda, T
   Isogai, J
   Murayama, H
   Ogino, H
AF Konagaya, Kensuke
   Yamamoto, Hiroyuki
   Nishida, Tomoki
   Morita, Tomotaka
   Suda, Tomoyuki
   Isogai, Jun
   Murayama, Hiroyuki
   Ogino, Hidemitsu
TI Negative-pressure wound therapy to treat thoracic empyema with
   COVID-19-related persistent air leaks: A case report
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE COVID-19; pneumothorax; persistent air leaks; empyema; open-window
   thoracostomy; negative-pressure wound therapy
ID OPEN-WINDOW THORACOSTOMY; PNEUMOTHORAX; PNEUMONIA
AB The novel coronavirus disease (COVID-19) has resulted in a global pandemic. Recently, COVID-19-related pneumothorax has gained attention because of the associated prolonged hospital stay and high mortality. While most cases of pneumothorax respond well to conservative and supportive care, some cases of refractory pneumothorax with persistent air leaks (PALs) do not respond to conventional therapies. There is a lack of evidence-based management strategies to this regard. We describe the case of a 73-year-old man with COVID-19-related acute respiratory distress syndrome (ARDS) who developed delayed tension pneumothorax with PALs caused by alveolopleural fistulas. Despite chest tube drainage, autologous blood pleurodesis, and endoscopic procedures, the PALs could not be closed, and were complicated by thoracic empyema. Subsequent minimally invasive open-window thoracostomy (OWT) with vacuum-assisted closure (VAC) therapy helped successfully control the refractory PALs. Serial chest computed tomography monitoring was useful for the early detection of the pneumothorax and understanding of its temporal relationship with air-filled lung cysts. Our case provides a new perspective to the underlying cause of refractory pneumothorax with PALs, secondary to COVID-19-related ARDS, and underscores the potential of OWT with VAC therapy as a therapeutic alternative in such cases.
C1 [Konagaya, Kensuke; Suda, Tomoyuki; Murayama, Hiroyuki; Ogino, Hidemitsu] Narita Tomisato Tokushukai Hosp, Dept Surg, Chiba, Japan.
   [Yamamoto, Hiroyuki] Narita Tomisato Tokushukai Hosp, Dept Cardiovasc Med, Chiba, Japan.
   [Suda, Tomoyuki] Shonan Kamakura Gen Hosp, Dept Gen Surg, Yokohama, Kanagawa, Japan.
   [Morita, Tomotaka] Narita Tomisato Tokushukai Hosp, Dept Anesthesiol, Chiba, Japan.
   [Nishida, Tomoki] Shonan Kamakura Gen Hosp, Dept Gen Thorac Surg, Yokohama, Kanagawa, Japan.
   [Isogai, Jun] Asahi Gen Hosp, Dept Radiol, Asahi, Japan.
RP Yamamoto, H (通讯作者)，Narita Tomisato Tokushukai Hosp, Dept Cardiovasc Med, Chiba, Japan.
EM hyamamoto19700908@gmail.com
RI Yamamoto, Hiroyuki/O-7668-2019
OI Yamamoto, Hiroyuki/0000-0003-4742-7653
CR Agrafiotis AC, 2021, J THORAC DIS, V13, P4519, DOI 10.21037/jtd-21-208
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NR 28
TC 2
Z9 4
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD AUG 11
PY 2022
VL 9
AR 970239
DI 10.3389/fmed.2022.970239
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6Q6NG
UT WOS:000891728500001
PM 36035387
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Cao, XL
   Hu, ZC
   Zhang, Y
   Wang, P
   Huang, SB
   Zhu, WK
   Dong, YX
   Xu, HL
   Tang, B
   Zhu, JY
AF Cao, Xiaoling
   Hu, Zhicheng
   Zhang, Yi
   Wang, Peng
   Huang, Shaobin
   Zhu, Wenkai
   Dong, Yunxian
   Xu, Hailin
   Tang, Bing
   Zhu, Jiayuan
TI Negative-Pressure Wound Therapy Improves Take Rate of Skin Graft in
   Irregular, High-Mobility Areas: A Randomized Controlled Trial
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BOLSTER
AB Background: Tie-over bolster dressing to secure a skin graft is associated with low graft take rates in irregular, high-mobility areas and suboptimal recipient wound beds. Negative-pressure wound therapy has become a well-established method to secure the graft, with a graft take rate of this method reported to be 96.7 percent. However, comparative efficacies between the two methods on irregular, high-mobility areas are yet to be determined.
   Methods: Patients eligible for skin graft were randomly assigned to receive either negative-pressure wound therapy or tie-over bolster dressing between December of 2014 and December of 2015. The primary outcome was determined by the take rate of skin grafts between postoperative days 5 and 7. The secondary outcomes were dressing time and postoperative complications, including hematoma, seroma, infection, displacement, and necrosis.
   Results: A total of 86 patients were assigned to receive either negative-pressure wound therapy (n = 43) or tie-over bolster dressing (n = 43) for skin graft treatment. Negative-pressure wound therapy significantly improved the take rate of grafts as compared with tie-over bolster dressing (97.2 versus 90.2 percent; p = 0.005). The improvements came from the grafts in irregular, high-mobility areas in the respective groups (97.6 versus 81.7 percent; p < 0.001). Negative-pressure wound therapy reduced skin graft displacement as a postoperative complication as compared with tie-over bolster dressing (one versus nine patients; p = 0.007). Dressing time using negative-pressure wound therapy was significantly shorter compared with tie-over bolster dressing (15.2 +/- 4.2 versus 27.4 +/- 4.3 minutes; p = 0.001).
   Conclusion: Negative-pressure wound therapy can improve the take rate of skin grafts in irregular, high-mobility areas and shorten the dressing time.
C1 [Tang, Bing] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burn Surg, 58 Zhongshan Rd 2, Guangzhou 510080, Peoples R China.
   Nantong Univ, Affiliated Hosp, Dept Burn & Plast Surg, Nantong, Peoples R China.
   Portland State Univ, Dept Chem, Portland, OR 97207 USA.
C3 Sun Yat Sen University; Nantong University; Portland State University
RP Tang, B (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burn Surg, 58 Zhongshan Rd 2, Guangzhou 510080, Peoples R China.; Zhu, JY (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burns, 58 Zhongshan Rd 2, Guangzhou 510080, Peoples R China.
EM tangbing@mail.sysu.edu.cn; zhujiay@mail.sysu.edu.cn
RI Dong, Yunxian/JMQ-1941-2023; Cao, Xiaoling/AAQ-3751-2020; Zhu,
   Wenkai/ABF-2042-2020
OI Dong, Yunxian/0000-0002-7112-2369; 
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NR 19
TC 13
Z9 17
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2022
VL 150
IS 6
BP 1341
EP 1349
DI 10.1097/PRS.0000000000009704
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6R5TA
UT WOS:000892364200035
PM 36161796
DA 2026-07-24
ER
PT J
AU Michalczyk, L
   Grabinska, A
   Banaczyk, B
   Braszko, M
   Andrychowicz, A
   Zabkowski, T
AF Michalczyk, Lukasz
   Grabinska, Agnieszka
   Banaczyk, Beata
   Braszko, Marek
   Andrychowicz, Aneta
   Zabkowski, Tomasz
TI Efficiency of Hyperbaric Oxygen Therapy Combined with Negative-Pressure
   Wound Therapy in the Treatment Strategy of Fournier's Gangrene -A
   Retrospective Study
SO UROLOGY JOURNAL
LA English
DT Article
DE Fournier Gangrene; treatment; wounds
ID VACUUM-ASSISTED CLOSURE
AB Purpose: Fournier's gangrene (FG) is a serious, aggressive, and often fatal multi-organism infection that affects the soft tissues of the perineum, rectum, and external genitalia. This study aimed to analyse the treatment's strategies of FG.
   Materials and Methods: This was a retrospective study of 35 patients with a diagnosis of FG admitted between 2016 and 2021. The diagnosis of FG was established on a clinical basis. Data on patient's age, sex, comorbidities, laboratory results (C-reactive protein (CRP), white blood cell (WBC), hematocrit (HCT), platelets (PLT), sodium, potassium, creatinine, procalcitonin, international normalized ratio (INR), and gangrene culture), extent of resection, antibiotics used, and hospitalisation time were obtained. The extent of resection was assessed on a scale of 1-5.
   Results: The study group consisted of all men (n=35) aged 24-85 (mean, 58) years. In 13/35 (37%) patients, hyperbaric oxygen therapy (HBOT) combined with negative-pressure wound therapy (NPWT) was used as a treatment for wound healing in Fournier's syndrome (group 1), and in 22/35 (63%) patients, open standard wound care was used (group 2). There were no fatalities in group 1, but four deaths (18%) were noted in group 2. The median extent of resection was 3 in group 1 and 2 in group 2. There was a correlation between the extent of resection and the use of HBOT combined with NPWT. The hospitalisation time was much shorter in group 2 (mean, 23 days) than in group 1 (mean, 26 days).
   Conclusion: HBOT and NPWT (group 1) showed advanced wound healing with a high efficiency rate. The longer median hospitalisation time in this group may be related to the severity of the injury.
C1 [Michalczyk, Lukasz; Banaczyk, Beata; Braszko, Marek] Praski Hosp, Dept Urol & Oncol Urol, Warsaw, Poland.
   [Grabinska, Agnieszka; Zabkowski, Tomasz] Mil Inst Med, Dept Urol, Warsaw, Poland.
   [Andrychowicz, Aneta; Zabkowski, Tomasz] Urol Outpatient Clin, Warsaw, Poland.
C3 Military Institute of Aviation Medicine
RP Michalczyk, L (通讯作者)，Praski Hosp, Dept Urol & Oncol Urol, Warsaw, Poland.
EM lukamichalczyk@gmail.com
RI Zabkowski, Tomasz/H-8645-2018
CR Assenza M, 2011, CLIN TER, V162, pE1
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NR 12
TC 9
Z9 10
U1 0
U2 4
PU UROL & NEPHROL RES CTR-UNRC
PI TEHRAN
PA NO 44, 9TH BOUSTAN ST, PASADARAN AVE, TEHRAN, 00000, IRAN
SN 1735-1308
EI 1735-546X
J9 UROL J
JI Urol. J.
PD JUL-AUG
PY 2022
VL 19
IS 4
BP 329
EP 332
DI 10.22037/uj.v18i.6797
PG 4
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 6S3DO
UT WOS:000892871700005
PM 34399437
DA 2026-07-24
ER
PT J
AU Santillo, S
   De Meis, E
   Mazzarella, G
   Bracchetti, G
   Ferrari, P
   Mansi, M
   Cicioni, G
   Assenza, M
AF Santillo, Sara
   De Meis, Edoardo
   Mazzarella, Gennaro
   Bracchetti, Greta
   Ferrari, Paolo
   Mansi, Monica
   Cicioni, Gaia
   Assenza, Marco
TI Management and treatment of Fournier's gangrene. Our Emergency
   Department Experience and literature review
SO ANNALI ITALIANI DI CHIRURGIA
LA English
DT Review
DE Fournier's gangrene; Loop colostomy; Negative Pressure Wound Therapy
ID VACUUM-ASSISTED CLOSURE; THERAPY; MORTALITY; COLOSTOMY
AB Fournier's Gangrene (FG) is an extremely serious condition of necrotizing soft tissue infection. The treatment of this critical condition is urgent but much debated, especially as regards the management of larger defects and wound closure, with various techniques being described in the current literature. Through a case series we aimed to present our surgical management of FG treated successfully with Negative Pressure Wound Therapy (NPWT) and performing a loop colostomy.
C1 [Santillo, Sara; De Meis, Edoardo; Mazzarella, Gennaro; Bracchetti, Greta; Ferrari, Paolo; Mansi, Monica; Cicioni, Gaia; Assenza, Marco] Sapienza Univ Rome, Dept Emergency Surg, Surg Fist Aid Unit, Rome, Italy.
C3 Sapienza University Rome
RP Santillo, S (通讯作者)，Sapienza Univ Rome, Dept Emergency Surg, Viale Policlin 155, I-00161 Rome, Italy.
EM santillosara@gmail.com
RI ; ASSENZA, Marco/LLK-2745-2024; Mazzarella, Gennaro/AGL-6790-2022
OI Cicioni, Gaia/0009-0009-2367-2890; Bracchetti,
   Greta/0000-0002-6562-8152; ASSENZA, Marco/0000-0002-0400-5410;
   Mazzarella, Gennaro/0000-0002-1206-9051
CR Assenza M, 2020, CLIN TER, V171, pE1, DOI 10.7417/CT.2020.2180
   Assenza M, 2010, CLIN TER, V161, pE95
   Assenza M, 2011, CLIN TER, V162
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NR 28
TC 2
Z9 3
U1 0
U2 2
PU EDIZIONI LUIGI POZZI
PI ROME
PA VIA PANAMA 68, 00198 ROME, ITALY
SN 0003-469X
EI 2239-253X
J9 ANN ITAL CHIR
JI Ann. Ital. Chir.
PD SEP-OCT
PY 2022
VL 93
IS 5
BP 571
EP 577
AR PII S0003469X22037642
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6T5YB
UT WOS:000893754500015
PM 36254773
DA 2026-07-24
ER
PT J
AU Shi, ST
   Wei, JY
   Lyu, GZ
   Zhong, XH
   Zhu, LH
   Yang, ML
AF Shi, Shuting
   Wei, Jiayu
   Lyu, Guozhong
   Zhong, Xiaohui
   Zhu, Lihong
   Yang, Minlie
TI Application of Comfort Therapy under eCASH Concept in Acute and Chronic
   Wound Treatment
SO DERMATOLOGY AND THERAPY
LA English
DT Article
DE Comfort therapy; Continuous negative pressure therapy (CNPWT); eCASH;
   Hamilton Anxiety Scale (HAM-A); Intermittent negative pressure wound
   therapy (INPWT); Visual Analogue Score (VAS); Wound care
ID VACUUM-ASSISTED CLOSURE; MECHANISMS; CARE; PAIN; IMPLEMENTATION;
   MANAGEMENT; SEDATION
AB Introduction Given the new ideas on wound care offered by the eCASH (early Comfort using Analgesia, minimal Sedatives, and maximal Humane care) and the substantial differences in clinical treatment between acute and chronic wounds, we aimed to investigate the effect of comfort therapy under the eCASH concept on analgesic sedation and accelerated wound healing in patients with acute or chronic wounds.Methods This randomized clinical study was conducted in two parts: acute wounds and chronic wounds. Patients with acute wounds were allocated into the acute wound control group (AWCG) and the acute wound experimental group (AWEG). Patients with chronic wounds were allocated into the chronic wound control group (CWCG) and two experimental groups, in which they received intermittent negative pressure therapy (IPTEG) and continuous negative pressure therapy (CPTEG). On the basis of the standard treatment for patients in the control group, eCASH therapy was used in the experimental groups. In addition, pain intensity and procedural anxiety were evaluated using the visual analogue score (VAS) and the Hamilton Anxiety Scale (HAM-A). In addition, clinical effects were assessed on the basis of the size of the surface area, rate of healing, and concentration of pro-inflammatory factors (IL-1, IL-6, TNF-alpha) and growth factors (VEGF, bFGF, TGF-beta 1).Results Compared with the control group, the VAS score and HAM-A score in the experimental groups were significantly decreased after intervention (P < 0.05). After intervention, the levels of IL-1 beta, IL-6, and TNF-alpha in AWEG, IPTEG, and CPTEG were significantly lower than those in AWCG. In addition, the levels of VEGF, bFGF, and TGF-beta 1 in IPTEG and CPTEG were significantly higher than those in CWCG (P < 0.05).Conclusion These results indicated that comfort therapy under the eCASH concept has a significant effect on ameliorating the pain and anxiety of patients, reducing the inflammatory reaction during the period of wound healing in the treatment of acute and chronic wounds.
C1 [Shi, Shuting; Wei, Jiayu; Lyu, Guozhong; Zhong, Xiaohui; Zhu, Lihong; Yang, Minlie] Jiangnan Univ, Wuxi Sch Med, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China.
   [Lyu, Guozhong; Zhu, Lihong; Yang, Minlie] Jiangnan Univ, Dept Burn & Plast Surg, Affiliated Hosp, Wuxi, Peoples R China.
C3 Jiangnan University; Jiangnan University
RP Zhu, LH; Yang, ML (通讯作者)，Jiangnan Univ, Wuxi Sch Med, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China.; Zhu, LH; Yang, ML (通讯作者)，Jiangnan Univ, Dept Burn & Plast Surg, Affiliated Hosp, Wuxi, Peoples R China.
EM fbjyzlh@163.com; jndxyml@sina.com
RI 史, 舒婷/HJZ-0638-2023; Shi, Shuting/HJZ-0638-2023
OI 史, 舒婷/0000-0003-2630-7580; 
FU Wuxi Health Committee [Z201710]; Wuxi science and Technology Bureau
   [N20192003]
FX The journal's Rapid Service Fee was supported by the Wuxi Health
   Committee(Z201710), and Wuxi Science and Technology Bureau(N20192003).
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NR 36
TC 7
Z9 8
U1 1
U2 6
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 2193-8210
EI 2190-9172
J9 DERMATOLOGY THER
JI Dermatol. Ther.
PD JAN
PY 2023
VL 13
IS 1
BP 299
EP 314
DI 10.1007/s13555-022-00852-5
EA DEC 2022
PG 16
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 7R5VW
UT WOS:000894583200001
PM 36472790
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Nishimura, M
   Mizutani, K
   Yokota, N
   Goto, H
   Akeda, T
   Kitagawa, H
   Habe, K
   Hayashi, A
   Yamanaka, K
AF Nishimura, Mai
   Mizutani, Kento
   Yokota, Naho
   Goto, Hiroyuki
   Akeda, Tomoko
   Kitagawa, Hiroshi
   Habe, Koji
   Hayashi, Akinobu
   Yamanaka, Keiichi
TI Treatment Strategy for Pyoderma Gangrenosum: Skin Grafting with
   Immunosuppressive Drugs
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE pyoderma gangrenosum; dysregulation of inflammasome function; pathergy;
   negative pressure wound therapy; skin grafting; immunosuppressive drugs
ID FORMS
AB Pyoderma gangrenosum (PG) is a relatively rare neutrophilic dermatosis presenting as a rapidly progressive and painful skin ulcer characterized by undermined borders and peripheral erythema. Immunosuppressive therapy is the first-line treatment for PG; however, large ulcers often take months or years to heal. Surgical treatments, such as negative pressure wound therapy (NPWT) and skin grafting, are still controversial due to the risk of inducing the pathergy phenomenon and eliciting PG development by traumatic factors. Herein, we report on four cases of PG treated with skin grafting, with or without NPWT, under the control of immunosuppressive drugs at our institution. All cases adapted well, but one case showed recurrence at the periphery of the grafted area five months postoperatively. The current patients were treated with the following doses of oral prednisolone (PSL): PSL 10 mg daily, PSL 5 mg daily + adalimumab 40 mg/week, PSL 12 mg + 6 mg of tacrolimus daily, and PSL 20 mg daily during skin grafting. No severe complications, including infections, were observed. Surgical treatments, such as skin grafting with or without NPWT, may accelerate wound healing, shorten the administration of analgesics and long-term immunosuppressive therapy, and reduce the risk of infection.
C1 [Nishimura, Mai; Mizutani, Kento; Yokota, Naho; Goto, Hiroyuki; Akeda, Tomoko; Kitagawa, Hiroshi; Habe, Koji; Yamanaka, Keiichi] Mie Univ, Dept Dermatol, Grad Sch Med, 2-174 Edobashi, Tsu 5148507, Japan.
   [Hayashi, Akinobu] Mie Univ, Dept Oncol Pathol, Grad Sch Med, 2-174 Edobashi, Tsu 5148507, Japan.
C3 Mie University; Mie University
RP Yamanaka, K (通讯作者)，Mie Univ, Dept Dermatol, Grad Sch Med, 2-174 Edobashi, Tsu 5148507, Japan.
EM yamake@med.mie-u.ac.jp
RI ; Kitagawa, Hiroshi/CAJ-3523-2022
OI Mizutani, Kento/0000-0001-5171-4909; Nishimura, Mai/0000-0003-3016-5933
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NR 17
TC 5
Z9 9
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2022
VL 11
IS 23
AR 6924
DI 10.3390/jcm11236924
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6X2KJ
UT WOS:000896248100001
PM 36498498
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, GQ
   Xu, HY
   Xu, GX
   Zhang, H
   Li, ZR
   Liu, DH
AF Wang, Guoqi
   Xu, Haiyan
   Xu, Gaoxiang
   Zhang, Hao
   Li, Zhirui
   Liu, Daohong
TI Clinical outcomes of negative pressure wound therapy with instillation
   vs standard negative pressure wound therapy for wounds: A meta-analysis
   of randomised controlled trials
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE instillation; negative pressure therapy; wound clinical outcome; wound
ID VACUUM-ASSISTED CLOSURE; ANTISEPTIC SOLUTION; IRRIGATION; MANAGEMENT;
   BIOBURDEN; BIOFILM; SALINE
AB Negative pressure wound therapy (NPWT) with or without instillation has been extensively applied for patients with multiple wound types. Whether NPWT with instillation is superior to NPWT alone is not known. This study aims to compare the efficacy between negative pressure wound therapy with instillation (NPWTi) and standard negative pressure wound therapy for wounds. The authors searched for randomised controlled trials (RCTs) in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials investigating clinical outcomes of negative pressure wound therapy with instillation vs standard negative pressure wound therapy for wounds. The registration number (protocol) on PROSPERO is CRD42022287178. Eight RCTs involved 564 patients met the inclusion criteria and were included finally. NPWTi showed a significant fewer surgeries and dressing changes (RR and 95% CI, -9.31 [-17.54, -1.08], P < 0.05), and smaller wound area after treatment (RR and 95% CI, -9.31 [-17.54, -1.08], P < 0.05) compared with NPWT. No significant difference was observed on healing rate, time to heal, length of stay, dehiscence, reinfection, reoperation and readmission between NPWTi and NPWT. The addition of instillation to NPWT could improve clinical outcomes regarding the number of surgeries and dressing changes, and wound area after treatment in patients with multiple wound types. However, because of the heterogeneity these conclusions still need to be further validated by more well-designed RCTs with large sample sizes.
C1 [Wang, Guoqi] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Pediat, Beijing, Peoples R China.
   [Wang, Guoqi] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Pediat, Beijing, Peoples R China.
   [Wang, Guoqi; Zhang, Hao; Liu, Daohong] Natl Clin Res Ctr Orthoped Sports Med & Rehabil, Beijing, Peoples R China.
   [Xu, Haiyan] Chinese Peoples Liberat Army Gen Hosp, Med Supplies Ctr, Dept Pharm, Beijing, Peoples R China.
   [Xu, Gaoxiang] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Orthoped, Beijing, Peoples R China.
   [Li, Zhirui] Chinese Peoples Liberat Army Gen Hosp, Hainan Hosp, Dept Orthoped, Sanya, Peoples R China.
   [Liu, Daohong] Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Orthoped, Beijing, Peoples R China.
   [Liu, Daohong] Peoples Liberat Army Gen Hosp, Med Ctr 8, Dept Orthoped, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Seventh Medical Center of Chinese PLA
   General Hospital; Chinese People's Liberation Army General Hospital;
   Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese People's Liberation Army
   General Hospital; Chinese People's Liberation Army General Hospital
RP Li, ZR (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Hainan Hosp, Dept Orthoped, Sanya, Peoples R China.; Liu, DH (通讯作者)，Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Orthoped, Beijing, Peoples R China.
EM lzr860514@163.com; domb@vip.sina.com
RI Xu, Haiyan/AAH-5062-2020; Li, Zhirui/OJT-0490-2025
CR Allen D, 2014, INT WOUND J, V11, P198, DOI 10.1111/j.1742-481X.2012.01073.x
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NR 38
TC 10
Z9 12
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2023
VL 20
IS 5
BP 1739
EP 1749
DI 10.1111/iwj.13989
EA DEC 2022
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA D5KM3
UT WOS:000897189700001
PM 36519410
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Seidel, D
AF Seidel, Doerthe
CA SAWHI Study Grp
TI Ambulatory negative pressure wound therapy of subcutaneous abdominal
   wounds after surgery: results of the SAWHI randomized clinical trial
SO BMC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Outpatients; Ambulatory care; Abdomen;
   Wound healing
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTIONS; QUALITY-OF-LIFE;
   ECONOMIC BURDEN; CARE; GROIN; FEASIBILITY; ALGINATE
AB Background: The SAWHI study showed that negative pressure wound therapy (NPWT) reduced treatment time by 7.8 days and had a 20.2% higher wound closure rate, but required a 2.1-day longer hospital stay than conventional wound treatment (CWT). The majority of study participants began treatment in the hospital and were discharged within 42 days. Methods: As an add-on to a multicenter randomized clinical trial, selected aspects of hospital discharge, outpatient treatment continuation, and subsequent wound closure outcomes are compared between the treatment arms in patients with subcutaneous abdominal wound healing impairment after surgery without fascia dehiscence in the per protocol population. Results: Within 42 days, wound closure rates were higher for outpatients in the NPWT arm than for outpatients in the CWT arm (27 of 55 [49.1%]) for both outpatient continuation of NPWT (8 of 26 [30.8%]) and outpatient CWT after NPWT was finished (27 of 121 [22.3%]). Time to wound closure was shorter for outpatients in the NPWT arm (outpatient transfer with: NPWT Mean +/- standard error 28.8 +/- 8.0 days; CWT 28.9 +/- 9.5 days) than in the conventional treatment arm (30.4 +/- 8.0 days). Nevertheless, within 30 study sites with patient enrollment, outpatient NPWT was performed in only 20 study sites for 65 of 157 study participants in the treatment arm. Conclusions: Outpatient NPWT of postsurgical abdominal wounds with healing impairment is feasible and successful and should be encouraged whenever possible. Study site specific avoidance of outpatient NPWT emerges as an additional reason for the prolonged hospitalization time.
C1 [Seidel, Doerthe; SAWHI Study Grp] Witten Herdecke Univ, Inst Forsch Operativen Med, Cologne, Germany.
RP Seidel, D (通讯作者)，Witten Herdecke Univ, Inst Forsch Operativen Med, Cologne, Germany.
EM DoertheSeidel@gmx.de
FU Projekt DEAL; Manufacturer, Kinetic Concepts Incorporated, an Acelity
   company
FX Open Access funding enabled and organized by Projekt DEAL. The
   SAWHI-study was funded by the manufacturer, Kinetic Concepts
   Incorporated, an Acelity company, (now part of 3 M) which included the
   financing of personnel and material resources for planning, conduct,
   analysis and report of the study. In addition, the manufacturer provided
   the negative pressure wound therapy (NPWT ) (brand name: Vacuum Assisted
   Closure (V.A.C.) Therapy devices) and associated consumable supplies.
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NR 40
TC 4
Z9 4
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD DEC 12
PY 2022
VL 22
IS 1
AR 425
DI 10.1186/s12893-022-01863-x
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6Z4HU
UT WOS:000897740600002
PM 36503505
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kawashima, J
   Sahara, K
   Yamagishi, S
AF Kawashima, Jun
   Sahara, Kota
   Yamagishi, Shigeru
TI Prophylactic negative pressure wound therapy following colorectal
   perforation: defining the risk factors for delayed wound healing
SO SURGERY TODAY
LA English
DT Article
DE NPWT; Colorectal perforation; Delayed wound healing
ID SURGICAL SITE INFECTION; CLOSED INCISION MANAGEMENT; VACUUM-ASSISTED
   CLOSURE; SURGERY; CATECHOLAMINES; COMPLICATIONS; HERNIA; IMPACT; REPAIR;
   CARE
AB Purpose The World Health Organization recommends prophylactic negative pressure wound therapy (NPWT) for high-risk SSI wounds, despite which delayed wound healing (DWH) remains a problem. The aim of this study was to define the risk factors for DWH under prophylactic NPWT following colorectal perforation (CP). Methods The subjects of this retrospective study were patients who underwent emergency laparotomy and prophylactic NPWT for CP between 2011 and 2019 at Fujisawa City Hospital in Japan. Multivariable analysis was performed to identify which perioperative factors impact DWH. Results A total of 58 patients met the inclusion criteria and the median period from surgery to wound closure was 12 days (IQR: 8-18). Most factors, including preoperative steroid use, diabetes, and serum albumin, were not associated with DWH, although patients requiring catecholamine were more likely to have DWH (OR 7.81, 95% CI 1.55-39.24, p = 0.013). The median in-hospital cost was more than double for patients with DWH vs. those without DWH (41.36 kUSD [IQR 24.95-51.89] vs. 20.32 kUSD [IQR 16.69-28.45], p < 0.001). Conclusion Catecholamine use was a greater risk factor for DWH than previously reported factors such as diabetes and the serum albumin level. Further study is needed to investigate strategies to prevent DWH and optimize the utilization of NPWT, especially in patients requiring catecholamine.
C1 [Kawashima, Jun; Sahara, Kota; Yamagishi, Shigeru] Fujisawa City Hosp, Dept Surg, 2-6-1 Fujisawa, Fujisawa, Kanagawa, Japan.
RP Yamagishi, S (通讯作者)，Fujisawa City Hosp, Dept Surg, 2-6-1 Fujisawa, Fujisawa, Kanagawa, Japan.
EM gishiyama1225@yahoo.co.jp
RI Kawashima, Jun/PQX-1843-2026
OI Kawashima, Jun/0000-0003-1072-0776
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NR 47
TC 3
Z9 5
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD JUN
PY 2023
VL 53
IS 6
BP 728
EP 735
DI 10.1007/s00595-022-02631-3
EA DEC 2022
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA H3GQ6
UT WOS:000897782800001
PM 36504070
DA 2026-07-24
ER
PT J
AU Liebman, RM
   Hanubal, KS
   Dziegielewski, PT
AF Liebman, Robert Michael
   Hanubal, Krishna S.
   Dziegielewski, Peter T.
TI Negative Pressure Wound Therapy in the Head and Neck: A Summary of Uses
   and Application Techniques
SO SEMINARS IN PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; head and neck; fistula; necrotizing
   fasciitis
ID VACUUM-ASSISTED CLOSURE; COST-EFFECTIVENESS; MANAGEMENT; SEAL
AB Negative pressure wound therapy (NPWT) has had an expanded role in the management of complex wounds including its increasing use for complex wounds in the head and neck region. Challenges for use in the head and neck region include variations in surface topography and the proximity of sensitive mouth, nose, ear, eye, and tracheal openings. Despite these challenges, NPWT has been used in the head and neck immediately following free flap surgery, to prepare wounds for skin grafting or local flaps, to treat orocutaneous and pharyngocutaneous fistulas, to treat necrotizing and deep neck space infections, to temporize and palliate, and to treat chronic wounds with exposed bone and hardware among others. This review demonstrates the proven track record of successful uses of NPWT in the aforementioned scenarios, provides suggestions to improve efficacy, as well as an algorithm for use in certain clinical situations.
C1 [Liebman, Robert Michael] Mem Hlth Univ, Otolaryngol Head & Neck Surg, Savannah, GA USA.
   [Hanubal, Krishna S.] Univ Florida, Dept Otolaryngol Head & Neck Surg, Coll Med, Gainesville, FL USA.
   [Dziegielewski, Peter T.] Univ Florida, Div Head & Neck Oncol & Microvasc Reconstruct Surg, Dept Otolaryngol Head & Neck Surg, Coll Med, Gainesville, FL USA.
   [Liebman, Robert Michael] Mem Hlth Univ, Otolaryngol Head & Neck Surg, Med Ctr, 4700 Waters Ave,Bldg 400, Savannah, GA 31404 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Liebman, RM (通讯作者)，Mem Hlth Univ, Otolaryngol Head & Neck Surg, Med Ctr, 4700 Waters Ave,Bldg 400, Savannah, GA 31404 USA.
EM rmliebman@gmail.com
OI Hanubal, Krishna/0000-0001-6825-9551
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NR 50
TC 9
Z9 12
U1 1
U2 3
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1535-2188
EI 1536-0067
J9 SEMIN PLAST SURG
JI Semin. Plast. Surg.
PD FEB
PY 2023
VL 37
IS 01
BP 9
EP 18
DI 10.1055/s-0042-1759562
EA DEC 2022
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8X4KC
UT WOS:000898583600001
PM 36776812
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Dias, TA
   Fernandes, DR
   dos Santos, BN
   dos Reis, PED
   Margatho, AS
   Silveira, RCDP
AF Dias, Thais Almeida
   Fernandes, Daiane Rubinato
   dos Santos, Bruna Nogueira
   dos Reis, Paula Elaine Diniz
   Margatho, Amanda Salles
   Silveira, Renata Cristina de Campos Pereira
TI Dressing to prevent surgical site infection in adult patients with
   cancer: a systematic review with meta-analysis
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Oncology surgery; Surgical wound infection; Surgical wound; Bandages;
   Occlusive dressings; Systematic review
ID PRESSURE WOUND THERAPY; SURGERY; TRIAL; LAPAROTOMY; OINTMENT
AB Purpose To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries. Methods This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis, with online searches conducted in the CINHAL, Cochrane Central, LILACS, PubMed, Scopus, Embase, Livivo, and Web of Science databases. An additional search was conducted in gray literature using Google Scholar. The risk of bias was assessed using RoB 2.0. The certainty of evidence was evaluated using the Grading of Recommendations Assessment and Development and Evaluation, and the results were synthesized in a descriptive manner and using meta-analysis. Results Eleven randomized clinical trials were conducted to compare different types of dressing-silver dressing with absorbent dressing (n = 3), mupirocin dressing with paraffin/no dressing (n = 1), honey-based dressing with absorbent dressing (n = 1), vitamin E and silicone-containing dressing with absorbent dressing (n = 1), and negative pressure wound therapy with absorbent dressing (n = 4)-and compare the usage duration of absorbent dressing (n = 1). Nine trials presented a low risk of bias, and two were classified as having uncertain bias. Compared with absorbent dressing, silver dressing did not reduce the risk of developing any type of SSI in 894 clinical trial participants (risk relative RR: 0.72; 95% confidence interval [CI] [0.44, 1.17] p = 0.18). Compared with absorbent dressing, negative pressure wound therapy did not reduce the risk of developing any type of SSI in the 1041 participants of two clinical trials (RR 0.68; 95% CI [0.31, 1.26] p = 0.22). The certainty of evidence of the three meta-analyses was considered low or very low for the prevention of SSI. We believe that this low certainty of evidence can be improved by conducting new studies in the future. Conclusion There is no evidence regarding which dressing is the most effective in preventing SSI in adult patients with cancer.
C1 [Dias, Thais Almeida; Fernandes, Daiane Rubinato; dos Santos, Bruna Nogueira; Margatho, Amanda Salles; Silveira, Renata Cristina de Campos Pereira] Univ Sao Paulo EERP USP, Ribeirao Preto Sch Nursing, Prof Helio Lourenco St 3900, Sao Paulo, Vila Monte Aleg, Brazil.
   [dos Reis, Paula Elaine Diniz] Univ Brasilia, BR-70910900 Brasilia, DF, Brazil.
C3 Universidade de Brasilia
RP Silveira, RCDP (通讯作者)，Univ Sao Paulo EERP USP, Ribeirao Preto Sch Nursing, Prof Helio Lourenco St 3900, Sao Paulo, Vila Monte Aleg, Brazil.
EM recris@eerp.usp.br
RI Martins, Bruna/ODJ-9030-2025; Pereira Silveira, Renata Cristina de
   Campos/K-7350-2012; Diniz dos Reis, Paula Elaine/AAS-1366-2020
OI Pereira Silveira, Renata Cristina de Campos/0000-0002-2883-3640;
   Margatho, Amanda/0000-0002-1006-9357; Dias, Thais
   Almeida/0000-0002-7601-3399; Diniz dos Reis, Paula
   Elaine/0000-0002-9782-3366
CR Anatone AJ, 2020, J AM ACAD ORTHOP SUR, V28, pE923, DOI 10.5435/JAAOS-D-19-00582
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NR 38
TC 5
Z9 5
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JAN
PY 2023
VL 31
IS 1
AR 11
DI 10.1007/s00520-022-07467-8
PG 13
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 7B1HO
UT WOS:000898893700010
PM 36512091
DA 2026-07-24
ER
PT J
AU de Souza, SC
   Mendes, CMC
   Meneses, JVL
   Dias, RM
AF de Souza, Sandro Cilindro
   Mendes, Carlos Mauricio Cardeal
   Meneses, Jose Valber Lima
   Dias, Rosana Menezes
TI Simplified vacuum dressing system: effectiveness and safety in wounds
   management
SO ACTA CIRURGICA BRASILEIRA
LA English
DT Article
DE Wounds and Injuries; Occlusive Dressings; Negative-Pressure Wound
   Therapy; Plastic Surgery
ID ASSISTED CLOSURE; PRESSURE; THERAPY; STATE
AB Purpose: Negative pressure wound therapy (NPWT) has revolutionized wound care, but its high cost reduces the procedure's availability. To solve the problem, streamlined vacuum dressings systems have been proposed, but the utility of these devices has been poorly studied. The objective of this study was to evaluate a simplified vacuum dressing system model (SVDM).Methods: Randomized clinical trial in which wounds were treated with SVDM compared to a complex occlusive dressing (silver hydrofiber, SHF). The analyzed outcomes were cleaning, presence of granulation tissue, clinical appearance, and indication for surgical closure of wounds.Results: Fifty injuries were treated (25 in each group), most located on lower limbs. SVDM proved to be more effective than SHF in the evaluated outcomes. Wound recalcitrance reduced the effectiveness of the equipment used. Despite its efficacy, complications occurred, the most frequent related to dressing changes: minor bleeding, foam adherence to a wound bed, and pain. Only for bleeding no favorable risk-benefit ratio was found. There were no severe complications, worsening conditions of injuries, or deaths.Conclusion: SVDM proved to be an effective and acceptably safe device for managing studied wounds.
C1 [de Souza, Sandro Cilindro; Mendes, Carlos Mauricio Cardeal] Univ Fed Bahia, Inst Ciencias Saude, Programa Posgrad, Salvador, BA, Brazil.
   [Meneses, Jose Valber Lima] Univ Fed Bahia, Fac Med, Dept Cirurgia Plast, Salvador, BA, Brazil.
   [Dias, Rosana Menezes] Hosp Carvalho Luz, Secretaria Saude Estado Bahia, Salvador, BA, Brazil.
C3 Universidade Federal da Bahia; Universidade Federal da Bahia
RP de Souza, SC (通讯作者)，Univ Fed Bahia, Inst Ciencias Saude, Programa Posgrad, Salvador, BA, Brazil.
EM sandrocilin@gmail.com
RI Mendes, Carlos Maurício Cardeal/AAC-1635-2019
OI Mendes, Carlos Maurício Cardeal/0000-0003-2089-5668; Souza,
   Sano/0000-0002-2888-6857; Lima meneses, Jose valber/0000-0001-5538-7108;
   Dias, Rosana/0000-0003-0030-2685
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NR 39
TC 2
Z9 4
U1 0
U2 1
PU ACTA CIRURGICA BRASILEIRA
PI SAO PAULO
PA ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL
SN 0102-8650
EI 1678-2674
J9 ACTA CIR BRAS
JI Acta Cir. Bras.
PY 2022
VL 37
IS 9
AR e370906
DI 10.1590/acb370906
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 7B6FW
UT WOS:000899227700001
PM 36515315
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gruener, JS
   Horch, RE
   Geierlehner, A
   Mueller-Seubert, W
   Cai, AJ
   Arkudas, A
   Ludolph, I
AF Gruener, Jasmin S.
   Horch, Raymund E.
   Geierlehner, Alexander
   Mueller-Seubert, Wibke
   Cai, Aijia
   Arkudas, Andreas
   Ludolph, Ingo
TI Is Instillational Topical Negative Pressure Wound Therapy in
   Peri-Prosthetic Infections of the Breast Effective? A Pilot Study
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE breast infection; peri-prosthetic infection; breast implant infection;
   silicone prostheses; negative pressure wound therapy; instillation
ID VACUUM-ASSISTED CLOSURE; TISSUE EXPANDER; IMPLANT; RECONSTRUCTION;
   SALVAGE; MANAGEMENT; HIP; COMPLICATIONS; SURGERY; DEVICE
AB Peri-prosthetic breast infections pose a risk of severe complications after breast implant surgery. The need to remove the breast implant, control the infection and perform additional surgical procedures are the consequences. Reimplantation of an alloplastic implant is only appropriate after an infection-free interval. In this retrospective cohort study, we investigated the effectiveness of negative pressure wound treatment with instillation and dwell time (NPWTi-d) on peri-prosthetic breast infections in combination with implant removal and antibiotic therapy. Twelve patients treated with NPWTi-d due to breast implant infection were included in the study. The bacterial burden was analyzed using wound swabs before and after NPWTi-d. Additionally, laboratory values were determined before NPWTi-d and immediately before wound closure. A total of 13 peri-prosthetic breast infections in 12 patients were treated using implant removal and NPWTi-d. In 76.9% (n = 10) of the cases, the patients had undergone alloplastic breast reconstruction following cancer-related mastectomy, whereas 23.1% (n = 3) of the patients had undergone breast augmentation for cosmetic reasons. The bacterial burden in the breast pocket decreased statistically significant after implant removal and NPWTi-d. No shift from Gram-positive to Gram-negative bacteria was observed. Inflammatory markers rapidly decreased following treatment. NPWTi-d had a positive impact on the healing process after peri-prosthetic breast infections, leading to a decrease in bacterial burden within the wounds and contributing to uneventful healing. Therefore, secondary reimplantation of breast prostheses might be positively influenced when compared to conventional implant removal and simple secondary closure. Further studies are required to conclusively establish the beneficial long-term effects of using NPWTi-d for the treatment of peri-prosthetic breast infections.
C1 [Gruener, Jasmin S.; Horch, Raymund E.; Geierlehner, Alexander; Mueller-Seubert, Wibke; Cai, Aijia; Arkudas, Andreas; Ludolph, Ingo] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Hosp Erlangen, Dept Plast & Hand Surg, Lab Tissue Engn & Regenerat Med, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Gruener, JS (通讯作者)，Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Hosp Erlangen, Dept Plast & Hand Surg, Lab Tissue Engn & Regenerat Med, D-91054 Erlangen, Germany.
EM jasmin.gruener@uk-erlangen.de
RI Horch, Raymund E/H-8128-2019; Arkudas, Andreas/AAQ-6745-2021; Cai,
   Aijia/JXN-8479-2024; Grüner, Jasmin/ABF-2976-2021
OI Horch, Raymund E/0000-0002-6561-2353; Arkudas,
   Andreas/0000-0002-2473-5816; Barth, Jasmin S/0000-0002-8033-7644;
   Ludolph, Ingo/0000-0003-4806-7717; Cai, Aijia/0000-0001-8738-9298; 
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NR 51
TC 11
Z9 11
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD DEC
PY 2022
VL 12
IS 12
AR 2054
DI 10.3390/jpm12122054
PG 12
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA 7E2ZB
UT WOS:000901041700001
PM 36556274
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Krasivskyi, I
   Ivanov, B
   Eghbalzadeh, K
   Fehlau, F
   Gerfer, S
   Grossmann, C
   Elderia, A
   Sabashnikov, A
   Rahmanian, PB
   Mader, N
   Djordjevic, I
   Wahlers, T
AF Krasivskyi, Ihor
   Ivanov, Borko
   Eghbalzadeh, Kaveh
   Fehlau, Frederike
   Gerfer, Stephen
   Grossmann, Clara
   Elderia, Ahmed
   Sabashnikov, Anton
   Rahmanian, Parwis Baradaran
   Mader, Navid
   Djordjevic, Ilija
   Wahlers, Thorsten
TI Sex-Associated Differences in Short-Term Outcomes in Patients with Deep
   Sternal Wound Infection after Open-Heart Surgery
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE deep sternal wound infection; cardiac surgery; sex; VAC therapy
ID BYPASS GRAFT-SURGERY; VACUUM-ASSISTED CLOSURE; RISK-FACTOR-ANALYSIS;
   GENDER-DIFFERENCES; CARDIAC-SURGERY; ARTERY; MEDIASTINITIS; MORTALITY;
   WOMEN; SURVIVAL
AB Deep sternal wound infection (DSWI) is a feared complication after cardiac surgery. The impact of sex-related differences on wound infection prevalence is poorly understood. Our aim was to evaluate the effect of sex on short-term outcomes in patients with DSWI after open-heart surgery. The study was a retrospective cohort study. A total of 217 patients with DSWI were identified and retrospectively analyzed using our institutional database. Patients were divided into two groups: males (n = 150) and females (n = 67). This study also includes a propensity score based matching (PSM) analysis (male group (n = 62) and female group (n = 62)) to examine the unequal groups. Mean age (p = 0.088) and mean body mass index (BMI) (p = 0.905) did not significantly differ between both groups. Vacuum assisted closure (VAC) therapy was performed among most patients (82.3% (male group) vs. 83.9% (female group), p = 0.432). The most commonly isolated bacteria from the wounds were Staphylococcus epidermidis and Staphylococcus aureus in both groups. Acute renal failure was significantly higher (p = 0.010) in the male group compared to the female group. However, dialysis rate did not significantly differ (p = 0.491) between male and female groups. Further secondary outcomes showed no major differences between the groups. Likewise, in-hospital mortality rate did not differ significantly (p = 0.680) between both groups. Based on our data, sex has no impact on deep wound infection prevalence after cardiac surgery.
C1 [Krasivskyi, Ihor; Eghbalzadeh, Kaveh; Fehlau, Frederike; Gerfer, Stephen; Grossmann, Clara; Elderia, Ahmed; Sabashnikov, Anton; Rahmanian, Parwis Baradaran; Mader, Navid; Djordjevic, Ilija; Wahlers, Thorsten] Univ Hosp Cologne, Dept Cardiothorac Surg, D-50937 Cologne, Germany.
   [Ivanov, Borko] Helios Hosp Siegburg, Dept Cardiothorac Surg, D-53721 Siegburg, Germany.
C3 University of Cologne
RP Krasivskyi, I (通讯作者)，Univ Hosp Cologne, Dept Cardiothorac Surg, D-50937 Cologne, Germany.
EM ihor.krasivskyi@uk-koeln.de
RI Sabashnikov, Anton/ABD-7044-2020; Gerfer, Stephen/ADX-0390-2022;
   Eghbalzadeh, Kaveh/PDX-7721-2025; Rahmanian, Parwis/E-5862-2010;
   Djordjevic, Ilija/AAN-3307-2020; Elderia, Ahmed/AEK-7200-2022
OI Krasivskyi, Ihor/0000-0003-0573-8218; Wahlers,
   Thorsten/0000-0002-8437-4119; Djordjevic, Ilija/0000-0002-5810-8626;
   Elderia, Ahmed/0000-0002-6859-5384
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NR 44
TC 4
Z9 7
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2022
VL 11
IS 24
AR 7510
DI 10.3390/jcm11247510
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7E6GE
UT WOS:000901263100001
PM 36556125
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Goldman, AH
   Tetsworth, K
AF Goldman, Ashton H.
   Tetsworth, Kevin
TI AAOS Clinical Practice Guideline Summary: Prevention of Surgical Site
   Infection After Major Extremity Trauma
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Article
ID OPEN FRACTURES; CLASSIFICATION
AB Prevention of Surgical Site Infections After Major Extremity Trauma Evidence-Based Clinical Practice Guideline is based on a systematic review of current scientific and clinical research. This clinical practice guideline (CPG) is designed to assist qualified physicians and clinicians when making treatment decisions for adults (18 years or older) who have sustained major extremity trauma. The CPG workgroup defined major extremity trauma as an open fracture, a major/high-energy closed fracture, a degloving injury, Morel-Lavallee lesions, a low-energy or high-energy gunshot injury, a crush injury, a blast injury, or any other moderate-energy to high-energy injury. This guideline contains 14 recommendations that evaluate preoperative, perioperative, and postoperative interventions to limit the risk of surgical site infections after major extremity trauma while also identifying and evaluating potential patient-specific risk factors to consider. Another six options formulated with either low-quality evidence, no evidence, or conflicting evidence are also presented and discussed in the CPG. These include the use of incisional negative-pressure wound therapy for high-risk surgical incisions, the implementation of an orthoplastic team, the possible role of hyperbaric O-2, the value of various preoperative skin preparations, and select modifiable and administrative risk factors.
C1 [Goldman, Ashton H.] Naval Med Ctr Portsmouth, Portsmouth, VA 23708 USA.
   [Goldman, Ashton H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Tetsworth, Kevin] Royal Brisbane & Womens Hosp, Brisbane, Australia.
   [Tetsworth, Kevin] Univ Queensland, Sch Med Brisbane, Brisbane, Australia.
C3 United States Department of Defense; United States Navy; Uniformed
   Services University of the Health Sciences - USA; Royal Brisbane &
   Women's Hospital; University of Queensland
RP Goldman, AH (通讯作者)，Naval Med Ctr Portsmouth, Portsmouth, VA 23708 USA.; Goldman, AH (通讯作者)，Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
EM ashton.goldman@gmail.com; ktetsworthmd@gmail.com
RI ; Tetsworth, Kevin/A-8005-2013
OI Goldman, Ashton/0000-0003-4481-9707; 
CR Agel J, 2013, J ORTHOP TRAUMA, V27, P379, DOI 10.1097/BOT.0b013e3182820d31
   American Academy of Othopaedic Surgeons, Clinical Practice Guideline for the Prevention of Total Hip and Knee Arthroplasty Periprosthetic Joint Infection in Patients Undergoing Dental Procedures
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NR 16
TC 24
Z9 32
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD JAN 1
PY 2023
VL 31
IS 1
BP E1
EP E8
DI 10.5435/JAAOS-D-22-00792
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 7G3DT
UT WOS:000902410300001
PM 36548150
DA 2026-07-24
ER
PT J
AU Wang, B
   Cheng, W
   Liu, FN
   Guo, ZH
   Ji, ZJ
   Sun, KM
   Yao, MY
AF Wang, Biao
   Cheng, Weyland
   Liu, Fangna
   Guo, Zhanhao
   Ji, Zejuan
   Sun, Keming
   Yao, Manye
TI Efficacy and safety of vancomycin-loaded calcium sulfate versus
   conventional surgical debridement for pediatric acute osteomyelitis: a
   retrospective study
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE vancomycin; Localized antibiotic delivery; Acute hematogenous
   osteomyelitis; Negative-pressure wound therapy; Parenteral therapy
ID ACUTE HEMATOGENOUS OSTEOMYELITIS; BONE-CEMENT; CHILDREN
AB Background: The purpose of this study was to evaluate the safety and efficacy of vancomycin-loaded calcium sulfate beads and negative-pressure wound therapy (NPWT) in treating children with acute hematogenous osteomyelitis (AHOM). Methods: A retrospective cohort study was conducted from January 2017 to January 2020 examining children (n = 60) with AHOM who were treated with surgical debridement followed by vancomycin-loaded calcium sulfate beads and NPWT (n = 32) and compared to treatment by conventional surgical debridement (n = 28) followed by NPWT. Conventional surgical treatment consisted of fenestration of necrotic infected bone, debridement of surrounding soft tissue, and washing of the medullary canal before the application of NPWT. In the vancomycin group, the antibiotic-loaded beads were implanted after washing the medullary canal and before the application of NPWT. Epidemiological factors, complications during the procedure, outcomes at last follow-up (30.0 & PLUSMN; 11.7 months, range 13-58 months), and laboratory parameters were documented and compared between the two groups. Results: Good outcomes were achieved at last follow-up in 71.4% of the conventional treatment group and 75% of the vancomycin group. In the vancomycin group, it took a mean of 4.8 & PLUSMN; 2.5 days for CRP levels to decrease to 50% of initial inflammatory levels compared to 13 & PLUSMN; 9.6 days for the conventional treatment group (p = 0.001, t-test). The conventional group also had seven patients who underwent four or more surgeries whereas no patients in the vancomycin group underwent more than three surgeries (p = 0.013, chi-square test). Conclusion: Localized vancomycin delivery with NPWT effective for treating cases of AHOM that required. No perioperative adverse reactions or complications occurred from this treatment method. Based on the shortened recovery period of CRP levels, prolonged administration of post-operational parenteral antibiotics can possibly be reduced with this treatment method.
C1 [Wang, Biao; Cheng, Weyland; Liu, Fangna; Guo, Zhanhao; Ji, Zejuan; Sun, Keming; Yao, Manye] Zhengzhou Univ, Dept Orthopaed Surg, Henan Childrens Hosp, Zhengzhou Childrens Hosp,Childrens Hosp, 33 Longhu Waihuan East Rd, Zhengzhou 450018, Henan, Peoples R China.
   [Cheng, Weyland] Zhengzhou Univ, Henan Prov Key Lab Childrens Genet & Metab Dis, Henan Childrens Hosp, Zhengzhou Childrens Hosp,Childrens Hosp, 33 Longhu Waihuan East Rd, Zhengzhou 450018, Henan, Peoples R China.
C3 Zhengzhou University; Zhengzhou University
RP Cheng, W; Sun, KM; Yao, MY (通讯作者)，Zhengzhou Univ, Dept Orthopaed Surg, Henan Childrens Hosp, Zhengzhou Childrens Hosp,Childrens Hosp, 33 Longhu Waihuan East Rd, Zhengzhou 450018, Henan, Peoples R China.; Cheng, W (通讯作者)，Zhengzhou Univ, Henan Prov Key Lab Childrens Genet & Metab Dis, Henan Childrens Hosp, Zhengzhou Childrens Hosp,Childrens Hosp, 33 Longhu Waihuan East Rd, Zhengzhou 450018, Henan, Peoples R China.
EM wey_c@hotmail.com; sunkeming@126.com; ymy19641@126.com
OI Cheng, Weyland/0000-0002-1846-2946
FU Henan Provincial Medical Science and Technology Research Plan Joint
   Construction Project;  [LHGJ20210667]
FX This work was supported by the Henan Provincial Medical Science and
   Tech-nology Research Plan Joint Construction Project (LHGJ20210667).
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NR 16
TC 9
Z9 11
U1 2
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD DEC 23
PY 2022
VL 23
IS 1
AR 1124
DI 10.1186/s12891-022-06105-y
PG 8
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA 7H8MX
UT WOS:000903452800001
PM 36564738
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Shahein, AR
   Krasaelap, A
   Ng, K
   Bitton, S
   Khan, M
   Manfredi, MA
   Lerner, DG
AF Shahein, Abdul R.
   Krasaelap, Amornluck
   Ng, Kenneth
   Bitton, Samuel
   Khan, Muhammad
   Manfredi, Michael A.
   Lerner, Diana G.
TI Esophageal Dilation in Children: A State of the Art Review
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Review
DE esophageal dilation; esophageal narrowing; esophageal perforation;
   esophageal stenosis; esophageal stricture; mitomycin-C; triamcinolone
   injection
ID STEROID INJECTION THERAPY; MITOMYCIN-C APPLICATION; EOSINOPHILIC
   ESOPHAGITIS; ANASTOMOTIC STRICTURES; ENDOSCOPIC DILATION; BALLOON
   DILATION; ADVERSE EVENTS; MANAGEMENT; ATRESIA; PERFORATIONS
AB Esophageal dilations in children are performed by several pediatric and adult professionals. We aim to summarize improvements in safety and new technology used for the treatment of complex and refractory strictures, including triamcinolone injection, endoscopic electro-incisional therapy, topical mitomycin-C application, stent placement, functional lumen imaging probe assisted dilation, and endoscopic vacuum-assisted closure in the pediatric population.
C1 [Shahein, Abdul R.] Drexel Univ, St Christophers Hosp Children, Div Pediat Gastroenterol Hepatol & Nutr, Coll Med, Philadelphia, PA USA.
   [Krasaelap, Amornluck] Childrens Mercy Hosp, Div Pediat Gastroenterol Hepatol & Nutr, Kansas City, MO USA.
   [Ng, Kenneth] Johns Hopkins Univ, Div Pediat Gastroenterol Hepatol & Nutr, Sch Med, Baltimore, MD USA.
   [Bitton, Samuel] Donald & Barbara Zucker Sch Med Hofstra Northwell, Div Pediat Gastroenterol Hepatol & Nutr, Hempstead, NY USA.
   [Khan, Muhammad] Childrens Natl Hosp, Div Pediat Gastroenterol Hepatol & Nutr, Washington, DC USA.
   [Manfredi, Michael A.] Univ Penn, Childrens Hosp Philadelphia, Div Pediat Gastroenterol Hepatol & Nutr, Philadelphia, PA USA.
   [Lerner, Diana G.] Med Coll Wisconsin, Div Pediat Gastroenterol Hepatol & Nutr, Milwaukee, WI USA.
   [Shahein, Abdul R.] Drexel Univ, St Christopher Hosp Children, Dept Pediat, Div Pediat Gastroenterol,Coll Med, 160 E Erie Ave, Philadelphia, PA 19134 USA.
C3 Drexel University; Children's Mercy Hospital; Johns Hopkins University;
   Northwell Health; Children's National Health System; University of
   Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia;
   Medical College of Wisconsin; Drexel University
RP Shahein, AR (通讯作者)，Drexel Univ, St Christopher Hosp Children, Dept Pediat, Div Pediat Gastroenterol,Coll Med, 160 E Erie Ave, Philadelphia, PA 19134 USA.
EM abdulrahman.shahein@mail.utoronto.ca
RI ; Bitton, Samuel/HJY-6351-2023; Krasaelap, Amornluck/AAA-2496-2021;
   Shahein, Abdul R/HLQ-0150-2023; Khan, Muhammad/GZK-7313-2022
OI Ng, Kenneth/0000-0002-1554-6204; Khan, Muhammad/0000-0002-2657-0904
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NR 56
TC 13
Z9 20
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD JAN
PY 2023
VL 76
IS 1
BP 1
EP 8
DI 10.1097/MPG.0000000000003614
PG 8
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA 7J8HG
UT WOS:000904824600001
PM 36122370
DA 2026-07-24
ER
PT J
AU Akkus, G
   Sert, M
AF Akkus, Gamze
   Sert, Murat
TI Diabetic foot ulcers: A devastating complication of diabetes mellitus
   continues non-stop in spite of new medical treatment modalities
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Diabetic foot ulcer; Peripheric artery disease; Macrovascular
   complications; Neuropathy; Wagner classification; Intralesionar growth
   factor treatment
ID HYPERBARIC-OXYGEN THERAPY; LOWER-EXTREMITY AMPUTATION; GROWTH-FACTOR;
   OXIDATIVE STRESS; IWGDF GUIDANCE; MANAGEMENT; NEUROPATHY;
   CLASSIFICATION; INFECTION; RISK
AB Diabetic foot ulcer is a devastating complication of diabetes mellitus and significant cause of mortality and morbidity all over the world and can be complex and costly. The development of foot ulcer in a diabetic patient has been estimated to be 19%-34% through their lifetime. The pathophysiology of diabetic foot ulcer consist of neuropathy, trauma and, in many patients, additional peripheral arterial disease. In particular, diabetic neuropathy leads to foot deformity, callus formation, and insensitivity to trauma or pressure. The standard algorithms in diabetic foot ulcer management include assessing the ulcer grade classification, surgical debridement, dressing to facilitate wound healing, off-loading, vascular assessment (status and presence of a chance for interventional vascular correction), and infection and glycemic control. Although especially surgical procedures are sometimes inevitable, they are poor predictive factors for the prognosis of diabetic foot ulcer. Different novel treatment modalities such as nonsurgical debridement agents, oxygen therapies, and negative pressure wound therapy, topical drugs, cellular bioproducts, human growth factors, energy-based therapies, and systematic therapies have been available for patients with diabetic foot ulcer. However, it is uncertain whether they are effective in terms of promoting wound healing related with a limited number of randomized controlled trials. This review aims at evaluating diabetic foot ulcer with regard to all aspects. We will also focus on conventional and novel adjunctive therapy in diabetic foot management.
C1 [Akkus, Gamze] Cukurova Univ, Dept Endocrinol, TR-33170 Adana, Turkey.
   [Sert, Murat] Cukurova Univ, Dept Internal Med, Med Fac, TR-33170 Adana, Turkey.
   [Akkus, Gamze] Cukurova Univ, Dept Endocrinol, Saricam St, TR-33170 Adana, Turkey.
C3 Cukurova University; Cukurova University; Cukurova University
RP Akkus, G (通讯作者)，Cukurova Univ, Dept Endocrinol, Saricam St, TR-33170 Adana, Turkey.
EM tugrulgamze@hotmail.com
RI /G-6103-2018; akkus, gamze/AAJ-7430-2020
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NR 93
TC 163
Z9 196
U1 14
U2 94
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD DEC 15
PY 2022
VL 13
IS 12
BP 1106
EP 1121
DI 10.4239/wjd.v13.i12.1106
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7K3LH
UT WOS:000905187000007
PM 36578865
OA Green Accepted, gold
HC Y
HP N
DA 2026-07-24
ER
PT J
AU Stichling, M
   Wiessner, A
   Kikhney, J
   Gatzer, R
   Mueller, M
   Scheuermann-Poley, C
   Moter, A
   Willy, C
AF Stichling, Marcus
   Wiessner, Alexandra
   Kikhney, Judith
   Gatzer, Renate
   Mueller, Martin
   Scheuermann-Poley, Catharina
   Moter, Annette
   Willy, Christian
TI Is There a Wound Recontamination by Eluates with High Bacterial Load in
   Negative-Pressure Wound Therapy with Instillation and Dwell Time?
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID IN-SITU HYBRIDIZATION; TARGETED OLIGONUCLEOTIDE PROBES; IDENTIFICATION;
   INFECTIONS; MANAGEMENT; FOAMS; BIOBURDEN; CONSENSUS; EFFICACY; IMPACT
AB Background:This study investigated bacterial colonization of the foam eluate after negative-pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) to obtain an indication of possible recontamination of the wound during NPWTi-d. To detect bacterial colonization and the extent of planktonic and nonplanktonic bioburden as comprehensively as possible, routine culture and molecular biology methods were used. Methods:Before (time point 1) and after (median 3.0 days; time point 2) NPWT (n = 15) and NPWTi-d with antiseptic installation (n = 15), wound bed [22 acute, eight chronic wounds; median age, 51 years (range, 24 to 91); 26 men], foam, and eluate were examined by routine culture methods and fluorescence in situ hybridization (FISH), polymerase chain reaction, and FISH sequencing (FISHseq). Results:At time point 2, 94.9% (37 of 39) of the pathogens identifiable in the eluate were also detected in the wound bed. Foam and eluate were always bacterially contaminated. NPWTi-d resulted in a significant reduction in the number of pathogen species compared with NPWT (NPWTi-d, time point 1 versus time point 2: P = 0.026; NPWT, time point 1 versus time point 2: not significant). Routine culture of wound bed samples at time point 2 identified only 28 of 52 (53.8%) of the pathogens, whereas examination of wound bed, foam, and eluate and additional FISHseq use detected 50 of 52 (96.2%) of the bacterial species. FISHseq identified biofilm in one and microcolonies in 10 wounds (time point 2). Conclusions:The bacterial load of the foam is flushed back into the wound during NPWTi-d. FISHseq should be used in addition to the routine culture method when pathogen identification and detection of nonplanktonic bacterial growth is particularly important for the patient's therapy.
C1 [Stichling, Marcus; Scheuermann-Poley, Catharina; Willy, Christian] Res & Treatment Ctr Sept Defect Wounds, Trauma & Orthoped Surg, Sept & Reconstruct Surg, Berlin, Germany.
   [Wiessner, Alexandra; Kikhney, Judith; Moter, Annette] Charite Univ Med Berlin, Inst Microbiol Infect Dis & Immunol, Biofilmctr, Berlin, Germany.
   [Gatzer, Renate; Mueller, Martin] Bundeswehr Mil Acad Hosp, Fed Armed Forces Germany, Dept Microbiol, Berlin, Germany.
   [Willy, Christian] Mil Acad Hosp, Fed Armed Forces Germany, Res & Treatment Ctr Sept Defect Wounds, Sept & Reconstruct Surg,Trauma & Orthoped Surg, Scharnhorststr 13, D-1310115 Berlin, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin
RP Willy, C (通讯作者)，Mil Acad Hosp, Fed Armed Forces Germany, Res & Treatment Ctr Sept Defect Wounds, Sept & Reconstruct Surg,Trauma & Orthoped Surg, Scharnhorststr 13, D-1310115 Berlin, Germany.
EM christianwilly@bundeswehr.org
RI Kikhney, Judith/HLH-0746-2023; Moter, Annette/IAL-9880-2023
OI Kikhney, Judith/0000-0002-4849-7947; Moter, Annette/0000-0003-1318-5780
FU German Armed Forces as a special research project of the Office of
   Defence Medical Research and Development [SoFo 15K4-S-121517]
FX The authors thank the medical colleagues of the Department of Trauma
   Surgery and Orthopaedics and the surgical assistants of their hospital
   who helped obtain samples from the study participants; Dr. Dennis Vogt
   for contributions and suggestions in the interpretation of the study
   results; Drs. Daniel Koeppen and Nadine Schaefer for support in the
   statistical analysis; and the biofilm center team for technical support
   during fluorescence in situ hybridization sequencing analysis. This
   study was funded by the German Armed Forces as a special research
   project (SoFo 15K4-S-121517) of the Office of Defence Medical Research
   and Development. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript
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NR 40
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2023
VL 151
IS 1
BP E136
EP E147
DI 10.1097/PRS.0000000000009770
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 7K6OP
UT WOS:000905400200030
PM 36251856
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Symeonidou, E
   Gkoutziotis, I
   Moulazimi, A
   Lagopoulos, V
   Kamparoudis, A
AF Symeonidou, Elissavet
   Gkoutziotis, Ioannis
   Moulazimi, Anastasia
   Lagopoulos, Vasileios
   Kamparoudis, Apostolos
TI Necrotizing Fasciitis of the Breast: A Case Series and Review of the
   Literature
SO SURGICAL INFECTIONS
LA English
DT Review
DE breast; debridement; mastectomy; necrotizing fasciitis; sepsis; surgical
   infections
ID SOFT-TISSUE INFECTION; CLINICAL PRESENTATION; MORTALITY; RARE;
   DETERMINANTS; LIMB
AB Background: Primary necrotizing fasciitis of the breast is a rare clinical condition and therefore a challenge for the clinical doctor. Its severity is associated with high morbidity and mortality.
   Patients and Methods: In the current article we present three cases that we treated in our surgical department with a combination of empirical antibiotic treatment, complete surgical debridement in stages, and negative pressure wound therapy.
   Conclusions: It appears that prompt diagnosis and surgical intervention are key for the successful management of these cases. The recognition of early clinical signs as well as risk factors are issues of great importance. A high index of suspicion is required for the early diagnosis and treatment, aiming to the best outcome for the patient.
C1 [Symeonidou, Elissavet; Gkoutziotis, Ioannis; Moulazimi, Anastasia; Lagopoulos, Vasileios; Kamparoudis, Apostolos] Aristotle Univ Thessaloniki, Ippokratio Gen Hosp Thessaloniki, Dept Surg 5, Thessaloniki, Greece.
   [Symeonidou, Elissavet] Aristotle Univ Thessaloniki, Ippokratio Gen Hosp Thessaloniki, Dept Surg 5, Konstantinoupoleos 49, Thessaloniki 54642, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki
RP Symeonidou, E (通讯作者)，Aristotle Univ Thessaloniki, Ippokratio Gen Hosp Thessaloniki, Dept Surg 5, Konstantinoupoleos 49, Thessaloniki 54642, Greece.
EM ellie.simeonidou@gmail.com
RI Lagopoulos, Vasileios/AAP-5018-2021; SYMEONIDOU, ELISSAVET/JBJ-8273-2023
OI Lagopoulos, Vasileios/0000-0002-2366-3283; 
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NR 41
TC 3
Z9 3
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD FEB
PY 2023
VL 24
IS 1
BP 19
EP 26
DI 10.1089/sur.2022.282
EA DEC 2022
PG 8
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA W4IU5
UT WOS:000905557000001
PM 36580649
DA 2026-07-24
ER
PT J
AU Wang, YL
   Liu, B
   Pi, YZ
   Hu, L
   Yuan, YL
   Luo, J
   Tao, YX
   Li, P
   Lu, S
   Song, W
AF Wang, Yanling
   Liu, Bang
   Pi, Yinzhen
   Hu, Li
   Yuan, Yeling
   Luo, Jiao
   Tao, Yixiao
   Li, Ping
   Lu, Shan
   Song, Wei
TI Risk factors for diabetic foot ulcers mortality and novel negative
   pressure combined with platelet-rich plasma therapy in the treatment of
   diabetic foot ulcers
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE diabetic foot ulcers (DFUs); diabetic patients without foot ulceration
   (NFU); negative pressure wound therapy (NPWT); platelet-rich
   plasma-fibrin glue (PRP); mortality
ID WOUND THERAPY; RECURRENCE
AB The purpose of this study was to assess the risk factors for morbidity and mortality of diabetic foot ulcers (DFUs). For the treatment of diabetic foot ulcers, negative pressure wound therapy (NPWT) combined with platelet-rich plasma-fibrin glue (PRP) was also investigated. There were 653 patients in the diabetic foot ulcer group and 510 patients in the diabetic patients without foot ulceration (NFU) group, for a total of 1163 patients in the study samples after individuals without follow-up were excluded. The patients were randomized into two groups: the negative pressure wound therapy group and the negative pressure wound therapy combined with the PRP group. The findings of the univariate analysis revealed the blood indicators for predicting diabetic foot ulcer morbidity risk factors, such as C-reactive protein, albumin, creatinine, alkaline phosphatase, procalcitonin, platelets, 25-hydroxyvitamin D, beta-2-microglobulin, monocyte ratio, low-density protein cholesterol (LDL), triglyceride, alanine aminotransferase (ALT), aminotransferase (AST), creatine kinase (CK) and total cholesterol. Using logistic regression analysis revealed only albumin and age to be independent predictors of diabetic foot ulcer mortality. Our study also revealed that, compared to negative pressure wound therapy alone, negative pressure wound therapy combined with PRP accelerated wound healing and reduced the mortality rate. According to the findings of this pilot study, new risk factors for diabetic foot ulcer morbidity and mortality have been found, and negative pressure wound therapy combined with PRP therapy may provide the first information that it is an effective adjunct treatment for diabetic foot ulcers.
C1 [Wang, Yanling; Liu, Bang; Luo, Jiao; Tao, Yixiao; Li, Ping; Lu, Shan] Hunan Normal Univ, Changsha Maternal & Child Hlth Hosp, Changsha, Peoples R China.
   [Pi, Yinzhen; Hu, Li] First Hosp Changsha, Changsha, Peoples R China.
   [Yuan, Yeling] Sun Yat sen Univ, Affiliated Hosp 7, Dept Pediat, Shenzhen, Peoples R China.
   [Song, Wei] Hubei Univ, Coll Hlth Sci & Engn, Natl & Local Joint Engn Res Ctr High Throughput Dr, Wuhan, Peoples R China.
C3 Hunan Normal University; Sun Yat Sen University; Hubei University
RP Song, W (通讯作者)，Hubei Univ, Coll Hlth Sci & Engn, Natl & Local Joint Engn Res Ctr High Throughput Dr, Wuhan, Peoples R China.
EM songwei_83@hubu.edu.cn
RI /A-2615-2013
FU National Natural Science Foundation of China; Changsha Municipal Natural
   Science Foundation [81903484]; Bureau of Public Health of Hunan Province
   [kq2014002]; Open Project Funding of National & Local Joint Engineering
   Research Center of High-throughput Drug Screening Technology
   [202103060456];  [M20202006];  [K20202001]
FX The study was supported by the National Natural Science Foundation of
   China (No. 81903484), the Changsha Municipal Natural Science Foundation
   (kq2014002), the Bureau of Public Health of Hunan Province
   (202103060456), and the Open Project Funding (M20202006 and K20202001)
   of National & Local Joint Engineering Research Center of High-throughput
   Drug Screening Technology.
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NR 24
TC 10
Z9 16
U1 0
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 16
PY 2022
VL 13
AR 1051299
DI 10.3389/fphar.2022.1051299
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7L5BT
UT WOS:000905981700001
PM 36588684
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU De Pellegrin, L
   Feltri, P
   Filardo, G
   Candrian, C
   Harder, Y
   Galetti, K
   De Monti, M
AF De Pellegrin, Laura
   Feltri, Pietro
   Filardo, Giuseppe
   Candrian, Christian
   Harder, Yves
   Galetti, Ken
   De Monti, Marco
TI Effects of negative pressure wound therapy with instillation and dwell
   time (NPWTi-d) versus NPWT or standard of care in orthoplastic surgery:
   A systematic review and meta-analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE negative pressure wound therapy; NPWT; NPWTi-d; acute wound; chronic
   wound; infection; orthoplastic surgery
ID VACUUM-ASSISTED CLOSURE; ANTISEPTIC SOLUTION; SALINE; MANAGEMENT; TRIAL;
   FOAM
AB Negative pressure wound therapy (NPWT) is a wound-dressing system that applies sub-atmospheric pressure on the surface of a wound to promote healing. An evolution of this technology, NPWT with solution instillation and dwell time (NPWTi-d), is increasingly being used to maximise wound closure and reduce failure rates. However, there is still a lack of evidence concerning its use in orthoplastic surgery. Therefore, the aim of this study is to compare NPWTi-d with NPWT and standard of care for wound management in orthoplastic surgery. A comprehensive literature search using PubMed, Web of Science, and Cochrane databases up to 15 March 2022 was performed, including studies describing the outcomes of NPWTi-d for traumatic/orthopaedic injuries. A meta-analysis on the number of surgical debridements, as well as the rate of complete wound closure and complications was carried out, although for other outcomes, a descriptive statistic was applied. Risk of bias and quality of evidence were assessed using the Downs& Black's Checklist for Measuring Quality. Thirteen studies with a total number of 871 patients were included, in which NPWTi-d demonstrated significantly higher primary wound closure and lower complication rates (P < .05). No difference in the number of surgical procedures required for final wound healing was observed. Moreover, five out of six studies showed better results for NPWTi-d when the change of the bioburden and bacterial count of the wound were analysed. A singular study investigating the length of the hospital stay of patients treated with NPWTi-d showed a reduction in the latter. The present meta-analysis proves that NPWTi-d is superior to NPTW or conventional dressings in orthoplastic wound care management, in terms of complete wound closure rate and the reduced number of complications. Still, the limited quality of the studies analysed shows that future randomised studies are needed to confirm the benefits and to identify the most appropriate recommendations for using NPWTi-d in orthoplastic surgery, as well as to investigate the cost-effectiveness of this wound-dressing system.
C1 [De Pellegrin, Laura; Galetti, Ken; De Monti, Marco] Ente Osped Cantonale EOC, Osped Reg Mendrisio, Dept Gen Surg, Mendrisio, Switzerland.
   [Feltri, Pietro; Filardo, Giuseppe; Candrian, Christian] Ente Osped Cantonale EOC, Serv Orthopaed & Traumatol, Dept Surg, Lugano, Switzerland.
   [Filardo, Giuseppe; Candrian, Christian; Harder, Yves] Univ Svizzera Italiana, Fac Biomed Sci, Lugano, Switzerland.
   [Harder, Yves; De Monti, Marco] Ente Osped Cantonale EOC, Osped Reg Lugano, Dept Plast Reconstruct & Aesthet Surg, Mendrisio, Switzerland.
   [De Monti, Marco] Ente Osped Cantonale EOC, Osped Reg Mendrisio, Dept Gen Surg, Via Turconi 23, CH-6850 Mendrisio, Switzerland.
C3 Universita della Svizzera Italiana
RP De Monti, M (通讯作者)，Ente Osped Cantonale EOC, Osped Reg Mendrisio, Dept Gen Surg, Via Turconi 23, CH-6850 Mendrisio, Switzerland.
EM marco.demonti@eoc.ch
RI De Monti, Marco/HJI-5543-2023
OI De Monti, Marco/0000-0003-0927-3438
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NR 36
TC 28
Z9 31
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2023
VL 20
IS 6
BP 2402
EP 2413
DI 10.1111/iwj.14072
EA JAN 2023
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA L4AN9
UT WOS:000906029100001
PM 36594491
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hu, X
   Li, HJ
   Guo, WT
   Xiang, HQ
   Hao, L
   Ai, FR
   Sahu, S
   Li, C
AF Hu, Xin
   Li, Huijian
   Guo, Wenting
   Xiang, Huiqin
   Hao, Liang
   Ai, Fanrong
   Sahu, Souradeep
   Li, Chen
TI Vacuum sealing drainage system combined with an antibacterial jackfruit
   aerogel wound dressing and 3D printed fixation device for infections of
   skin soft tissue injuries
SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
LA English
DT Article
ID COMPOSITE
AB Injuries and infections of skin and soft tissue are commonly encountered in primary health care and are challenging to manage. Vacuum sealing drainage (VSD) is generally used in clinical treatment, but current commercial methods of VSD have some disadvantages, such as easy blockage, nonantibacterial effects, and inconvenient curved surfaces. Herein, we report a functional zinc oxide/jackfruit aerogel (ZnO/JFA) composite material that is ultralight, superabsorbent and antibacterial as a new antibacterial VSD wound dressing. The JFA is carbonized from fresh jackfruit, and the JFA exhibits superhydrophilicity and superabsorbability. The water absorption rate of JFA was up to 1209.39%, and the SBF absorption rate was up to 1384.22%. The water absorption rate of ZnO/JFA was up to 494.47%, and the SBF absorption rate was up to 473.71%. The JFA and ZnO/JFA possess a pipeline structure, which is beneficial for absorbing wound exudates. In addition, surface modification of nanosized ZnO and its effects on antibacterial properties and biocompatibility were performed. When the concentration of ZnO/JFA was 3.125 mg/mL, the survival rate of human fibroblast cells was close to 80%, while the antibacterial rates against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli were up to 99.06%, 75.28% and 93.58%, respectively. Moreover, a 3D printed assisted device was introduced to make the ZnO/JFA wound dressing more attached to the bottom of the wound on a curved surface. An integrated device was formed under the printing mold, and then animal experiments were conducted in vivo. The results showed that a healing rate of almost 100% for infected skin wounds was obtained with this novel VSD device after 14 days, compared to only 79.65% without the VSD device. This novel VSD with a negative pressure suction dressing is beneficial for healing infectious wounds.
C1 [Hu, Xin; Li, Huijian; Hao, Liang; Sahu, Souradeep; Li, Chen] Nanchang Univ, Dept Orthoped Surg, Affiliated Hosp 2, Nanchang 330006, Jiangxi, Peoples R China.
   [Guo, Wenting; Xiang, Huiqin] Nanchang Univ, Clin Med Sch 2, Nanchang 330006, Jiangxi, Peoples R China.
   [Ai, Fanrong] Nanchang Univ, Sch Mech & Elect Engn, Nanchang 330031, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University; Nanchang University
RP Li, C (通讯作者)，Nanchang Univ, Dept Orthoped Surg, Affiliated Hosp 2, Nanchang 330006, Jiangxi, Peoples R China.
EM 15679191922@163.com
RI hao, liang/NBX-8636-2025; Guo, Wenting/GYQ-5456-2022
FU National Natural Science Foundation of China [31960207]; Key Research
   and Development Projects of Jiangxi Science and Technology Department
   [20181BBG70026]; Youth Science Foundation of Jiangxi Province
   [20202BABL216056]; Foundation of Jiangxi Provincial Department of
   Education [1160266]; Hospital Project of The Second Affiliated Hospital
   of Nanchang University [2016YNZJ12007]; Foundation of Health and Family
   Plan-ning Commission of Jiangxi Province [202130487]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 31960207 to FA), Key Research and Development
   Projects of Jiangxi Science and Technology Department(No. 20181BBG70026
   to CL), Youth Science Foundation of Jiangxi Province (No.
   20202BABL216056 to CL), Foundation of Jiangxi Provincial Department of
   Education (No. 1160266 to CL), Hospital Project of The Second Affiliated
   Hospital of Nanchang University (No.2016YNZJ12007 to CL), and Foundation
   of Health and Family Plan-ning Commission of Jiangxi Province (No.
   202130487 to CL)
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NR 31
TC 14
Z9 15
U1 4
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-4530
EI 1573-4838
J9 J MATER SCI-MATER M
JI J. Mater. Sci.-Mater. Med.
PD DEC 31
PY 2022
VL 34
IS 1
AR 1
DI 10.1007/s10856-022-06709-9
PG 10
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 7L8PG
UT WOS:000906220300005
PM 36586047
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, SW
   Wang, CC
   Song, WJ
   Wang, J
   Zhao, SB
AF Liu, Shiwei
   Wang, Congcong
   Song, Wenjing
   Wang, Jun
   Zhao, Shibo
TI A case report of delayed treatment of acute exertional osteofascial
   compartment syndrome in the anterior compartment of the calf
SO MEDICINE
LA English
DT Article
DE acute exertional osteofascial compartment syndrome; fasciotomy; nerve
   injury; vacuum sealing drainage
ID LEG
AB Rationale:Acute exertional osteofascial compartment syndrome (OCS) is a rare cause of lower-leg pain and is often associated with delayed diagnosis, which can lead to irreversible muscle and nerve damage. Patient concerns:A 23-year-old man presented with acute-onset anterior calf pain and ankle dorsiflexion after hiking. Diagnosis:The patient's pain was initially diagnosed as muscle strain at a county hospital, but was eventually diagnosed as OCS at our hospital 8 days after the injury. This case presents several challenges in the diagnosis and treatment phases. Interventions:Three surgeries were performed in total. On the day after admission (9 days after injury), fasciotomy was performed, followed by vacuum sealing drainage (VSD). Six days after the first surgery, necrotic muscle debridement was performed and VSD was reperformed. Ten days after the second surgery, the covering foam material was removed and the incision was sutured. Outcomes:Satisfactory postoperative results were achieved. The erythrocyte sedimentation rate, C-reactive protein level, and white blood cell count were within normal ranges. The skin healed well, and nerve damage and muscle strength improved significantly 3 months after surgery. Lessons:OCS in the absence of trauma or fracture is rare, but treatment delays can have devastating consequences. Acute nontraumatic OCS requires prompt diagnosis and surgical intervention to prevent adverse outcomes. VSD is an effective surgical treatment for this disease.
C1 [Liu, Shiwei; Wang, Congcong; Wang, Jun; Zhao, Shibo] Weifang Med Univ, Affiliated Hosp 1, Joint Surg Dept, Weifang 261000, Shandong, Peoples R China.
   [Song, Wenjing] Weifang Med Univ, Affiliated Hosp 1, Oncol Dept, Weifang, Shandong, Peoples R China.
C3 Shandong Second Medical University; Shandong Second Medical University
RP Zhao, SB (通讯作者)，Weifang Med Univ, Affiliated Hosp 1, Joint Surg Dept, Weifang 261000, Shandong, Peoples R China.
EM 729167145@qq.com; 1764099203@qq.com; 2455187154@qq.com;
   1764099203@qq.com; 18743098435@sohu.com
RI Song, Wenjing/AGB-1735-2022
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NR 21
TC 0
Z9 0
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC 30
PY 2022
VL 101
IS 52
DI 10.1097/MD.0000000000032449
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7M9FZ
UT WOS:000906956700030
PM 36596050
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Poirier, A
   Albuisson, E
   Bihain, F
   Granel-Brocard, F
   Perez, M
AF Poirier, Antoine
   Albuisson, Eliane
   Bihain, Florence
   Granel-Brocard, Florence
   Perez, Manuela
TI Does Preventive Negative Pressure Wound Therapy (NPWT) reduce local
   complications following Lymph Node Dissection (LND) in the management of
   metastatic skin tumors?
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy (NPWT); Lymph node dissection (LND);
   Axillary-Inguinal-Melanoma-Squamous; Cell Carcinoma (SCC)-Merkel?s;
   neuroendocrine tumor; Lymphocele-Lymphedema
ID VACUUM-ASSISTED CLOSURE; CANCER; LYMPHADENECTOMY; INFECTION
AB Introduction: Axillary and inguinal lymph node dissection (LND) are performed in metastatic skin tumors with several local complications, such as lymphorrhea, lymphoceles, and lymphedema. The purpose of this study is to determine whether negative pressure wound therapy (NPWT) applied as a preventive measure could improve outcomes.Materials and Methods: A monocentric study included patients who underwent axillary or inguinal LND from May 2010 to March 2020, with a retrospective evaluation of prospectively collected data. Patients were divided into two groups: the conventional wound care (CWC) and the NPWT groups. Patients were systematically reviewed at D7, D30, and at 1 year postopera-tive, and data regarding lymphorrhea, lymphoceles, and lymphedema were collected.Results: A total of 109 axillary and inguinal LND were performed. NPWT was applied on 68 LND and CWC on 41 LND. The variables, diabetes, smoking, gender, associated treatments, and primary pathology (melanoma, squamous cell carcinoma, or Merkel tumors) were similar in both groups. Analyses have shown a significant difference in the rate of scar disunion during the first month between the two groups ( p = 0.045 between D1 and D7; p = 0.011 between D8 and D30), as well as the presence of lymphorrhea ( p = 0.000 between D1 and D7; p = 0.002 between D8 and D30). The rate of lymphoedema was significantly reduced in the NPWT group versus CWC (p =0.000 between D8 and D30; p =0.034 between D31 and 1 year).Conclusion: NPWT reduces local complications (scar disunion, lymphorrhea, and lymphedema) during the first year following LND in the management of node metastatic skin tumors.(c) 2022 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by El-sevier Ltd. All rights reserved.
C1 [Poirier, Antoine; Bihain, Florence; Perez, Manuela] CHRU Nancy, Dept Chirurg Viscerale Metab & Cancerol CVMC, Hop Brabois, Rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
   [Albuisson, Eliane] CHRU Nancy, Hop Brabois, Rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
   [Granel-Brocard, Florence] CHRU Nancy, Serv Dermatol & Allergol, Hop Brabois, Rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
C3 CHU de Nancy; CHU de Nancy; CHU de Nancy
RP Poirier, A (通讯作者)，CHRU Nancy, Dept Chirurg Viscerale Metab & Cancerol CVMC, Hop Brabois, Rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
EM a.poirier@chru-nancy.fr
OI Bihain, Florence/0000-0002-4359-5134
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
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NR 23
TC 6
Z9 7
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2022
VL 75
IS 12
BP 4403
EP 4409
DI 10.1016/j.bjps.2022.08.054
EA NOV 2022
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 7N0OK
UT WOS:000907046600008
PM 36283927
DA 2026-07-24
ER
PT J
AU Madrigal, P
   Moshal, T
   Bernabe, R
   Yenikomshian, H
   Gillenwater, J
AF Madrigal, Paloma
   Moshal, Tayla
   Bernabe, Rendell
   Yenikomshian, Haig
   Gillenwater, Justin
TI A comparison of negative pressure wound therapy modalities, VAC versus
   non-commercial NPWT alternatives: A systematic review of RCTs/CCTs
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Review
ID ASSISTED CLOSURE; SKIN-GRAFTS
AB Background: Negative pressure wound therapy (NPWT) has been described as an effective treatment for wounds of various etiologies, however it is expensive. Various authors have investigated low-cost alternatives to commercial NPWT devices. A systematic review summarizing their findings is needed for clinicians operating in resource-limited locations and for those interested in potential cost savings.Methods: A systematic review was performed evaluating articles from Cochrane, PubMed and EMBASE. The studies included randomized controlled trials (RCTs) and controlled clinical trials (CCTs) that compared commercially available Vacuum-Assisted Closure (VAC) devices with non-commercial NPWT modalities in human subjects. Results: Seven hundred and ninety-six articles were retrieved, of which six met inclusion criteria. All six studies were RCTs and had in total 409 participants with wounds of various etiologies, including acute, chronic, and traumatic wounds. All studies compared VAC to a non-commercial NPWT device. Five studies were found to have low risk of bias, and one study had high risk of bias. There were three types of non-commercial NPWT devices used: wall suction applied to a sealed gauze dressing (GSUC), AquaVac, and Redon drains. The following outcomes were assessed: granulation tissue formation, effect on wound size area, skin graft take, pain/ time associated with dressing changes and cost. In trials that compared GSUC vs VAC, there was no significant difference between the two groups for the following outcomes: granulation tissue formation, effect on wound size and skin graft take. GSUC dressings were significantly less painful and less time-consuming than VAC dressings. In the trial that compared AquaVac vs VAC, there was no significant difference between the two groups for the following outcomes: granulation tissue formation, effect on wound size, and the time or pain associated with dressing changes. In the trial that compared Redon drains vs VAC, there was significantly more granulation tissue formed in the VAC group. All non-commercial NPWT devices were found to be less costly than VAC.Conclusion: The data from the trials evaluated in this review indicate that GSUC and AquaVac are two non-commercial NPWT devices that are non-inferior to VAC for various outcomes while also being less costly. GSUC was less painful and less time-consuming than VAC. Of the non-commercial NPWT devices evaluated in this review, GSUC had the most evidence to support its future use. Prospective, multi-institutional RCTs with a large sample size are needed to confirm the findings presented here.
C1 [Madrigal, Paloma; Moshal, Tayla] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA.
   [Bernabe, Rendell] Rutgers Robert Wood Johnson Med Sch, New Brunswick, NJ USA.
   [Yenikomshian, Haig; Gillenwater, Justin] Univ Southern Calif, Div Plast & Reconstruct Surg, Keck Sch Med, Los Angeles, CA 90033 USA.
C3 University of Southern California; Rutgers University System; Rutgers
   University New Brunswick; Rutgers University Biomedical & Health
   Sciences; University of Southern California
RP Gillenwater, J (通讯作者)，Univ Southern Calif, Div Plast & Reconstruct Surg, Keck Sch Med, Los Angeles, CA 90033 USA.
EM Justin.Gillenwater@med.usc.edu
OI Maigal, Paloma/0000-0002-2646-1708; Bernabe,
   Rendell/0000-0002-4574-8640; Moshal, Tayla/0000-0002-9078-7809; BERNABE,
   RENDELL/0009-0007-5334-691X; Gillenwater, Justin/0000-0001-9410-6030
CR Anesäter E, 2011, INT WOUND J, V8, P336, DOI 10.1111/j.1742-481X.2011.00790.x
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NR 28
TC 8
Z9 13
U1 0
U2 4
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD NOV
PY 2022
VL 31
IS 4
BP 630
EP 636
DI 10.1016/j.jtv.2022.10.002
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA 7N2KA
UT WOS:000907172100001
PM 36289040
DA 2026-07-24
ER
PT J
AU Yadav, AK
   Mishra, S
   Khanna, V
   Panchal, S
   Modi, N
   Amin, S
AF Yadav, Amit Kumar
   Mishra, Shaswat
   Khanna, Vikram
   Panchal, Sameer
   Modi, Nihar
   Amin, Stavan
TI Comparative study of various dressing techniques in diabetic foot ulcers
   in the Indian population: a single-center experience
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Diabetic foot ulcer; Vacuum-assisted closure; Foam dressing;
   Conventional dressing; Cost-effective; Hospital stay
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; MULTICENTER
AB Introduction:A prospective randomized study was conducted to evaluate and compare the efficacy of conventional dressing, foam dressing, and vacuum-assisted closure (VAC) in the management of diabetic foot ulcers (DFUs). Material and methods:Ninety patients with DFU were included in the study conducted between 2018 and 2021 at a tertiary care center. Group 1 patients (n = 30) were treated with conventional dressing, group 2 patients (n = 30) with foam dressing, and group 3 patients (n = 30) with VAC dressing. The duration of treatment, number of debridement, need for the secondary procedure, cost of treatment, and duration of hospital stay were compared between the three groups. Results:There was a significant difference in the duration of treatment among the three groups with VAC being the least (group 1, 31.17 days; group 2, 24.13 days; group 3, 15.17 days). The mean number of debridement was also significantly less in the VAC group (2.37, 2.43, and 1.60, respectively). The need for the secondary procedure, like flap or skin graft, was also the least in the VAC group, although insignificant. The mean hospital stay of the study subjects was 31.17 days, 24.13 days, and 15.17 days in the 3 groups, respectively. The mean cost of the treatment was 3076.67 INR, 3717.33 INR, and 10,680 INR, respectively. Conclusion:VAC dressing is the best option amongst the available dressing modalities in terms of faster healing and a short hospital stay. Foam dressing does provide an economically viable option with better results than conventional dressing.
C1 [Yadav, Amit Kumar; Panchal, Sameer] SIR HN Reliance Fdn Hosp & Res Ctr, Mumbai, India.
   [Mishra, Shaswat; Modi, Nihar; Amin, Stavan] Grant Govt Med Coll & Sir JJ Grp Hosp, Mumbai, India.
   [Khanna, Vikram] Ranjana Hosp, Allahabad, India.
RP Mishra, S (通讯作者)，Grant Govt Med Coll & Sir JJ Grp Hosp, Mumbai, India.
EM amit_aur09@yahoo.com; shaswatmishra1994@gmail.com; 86.khanna@gmail.com;
   panchalsameer1992@gmail.com; modi.nihar95@gmail.com;
   stavan120596@gmail.com
RI yadav, amit/ADR-1115-2022; Amin, Stavan/JAA-9909-2023
OI MISHRA, SHASWAT/0000-0003-4863-462X
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NR 24
TC 11
Z9 14
U1 0
U2 7
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD OCT
PY 2023
VL 43
IS 5
BP 647
EP 653
DI 10.1007/s13410-022-01163-3
EA JAN 2023
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA S8IM4
UT WOS:000907751300001
PM 36619905
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Zarnescu, NO
   Dumitrascu, I
   Zarnescu, EC
   Costea, R
AF Zarnescu, Narcis Octavian
   Dumitrascu, Ioana
   Zarnescu, Eugenia Claudia
   Costea, Radu
TI Abdominal Compartment Syndrome in Acute Pancreatitis: A Narrative Review
SO DIAGNOSTICS
LA English
DT Review
DE acute pancreatitis; abdominal compartment syndrome; compartment
   syndrome; intra-abdominal hypertension; surgery
ID LINEA ALBA FASCIOTOMY; ELEVATED INTRAABDOMINAL PRESSURE; CRITICALLY-ILL
   PATIENTS; INTENSIVE-CARE-UNIT; ORGAN FAILURE; DECOMPRESSIVE LAPAROTOMY;
   POLYCOMPARTMENT SYNDROME; FLUID RESUSCITATION; PERFUSION-PRESSURE;
   D-LACTATE
AB Abdominal compartment syndrome (ACS) represents a severe complication of acute pancreatitis (AP), resulting from an acute and sustained increase in abdominal pressure >20 mmHg, in association with new organ dysfunction. The harmful effect of high intra-abdominal pressure on regional and global perfusion results in significant multiple organ failure and is associated with increased morbidity and mortality. There are several deleterious consequences of elevated intra-abdominal pressure on end-organ function, including respiratory, cardiovascular, gastrointestinal, neurologic, and renal effects. It is estimated that about 15% of patients with severe AP develop intra-abdominal hypertension or ACS, with a mortality rate around 50%. The treatment of abdominal compartment syndrome in acute pancreatitis begins with medical intervention and percutaneous drainage, where possible. Abdominal compartment syndrome unresponsive to conservatory treatment requires immediate surgical decompression, along with vacuum-assisted closure therapy techniques, followed by early abdominal fascia closure.
C1 [Zarnescu, Narcis Octavian; Dumitrascu, Ioana; Zarnescu, Eugenia Claudia; Costea, Radu] Carol Davila Univ Med & Pharm, Dept Gen Surg, Bucharest 050474, Romania.
   [Zarnescu, Narcis Octavian; Dumitrascu, Ioana; Zarnescu, Eugenia Claudia; Costea, Radu] Univ Emergency Hosp Bucharest, Dept Surg 2, Bucharest 050098, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Zarnescu, NO; Zarnescu, EC (通讯作者)，Carol Davila Univ Med & Pharm, Dept Gen Surg, Bucharest 050474, Romania.; Zarnescu, NO; Zarnescu, EC (通讯作者)，Univ Emergency Hosp Bucharest, Dept Surg 2, Bucharest 050098, Romania.
EM narcis.zarnescu@umfcd.ro; eugenia.zarnescu@umfcd.ro
RI Zarnescu, Narcis Octavian/J-4196-2015; Zarnescu, Eugenia
   Claudia/AFV-2571-2022; Costea, Radu/AAB-1368-2020
OI Zarnescu, Narcis Octavian/0000-0003-3973-6309; Costea,
   Radu/0000-0003-0509-693X
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NR 137
TC 19
Z9 23
U1 2
U2 24
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD JAN
PY 2023
VL 13
IS 1
AR 1
DI 10.3390/diagnostics13010001
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7P9GF
UT WOS:000909005300001
PM 36611293
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hsiao, HY
   Hsieh, WC
   Chang, FCS
   Liu, JW
   Kuo, WL
   Cheong, DCF
   Huang, JJ
AF Hsiao, Hui-Yi
   Hsieh, Wei-Chuan
   Chang, Frank Chun-Shin
   Liu, Jia-Wei
   Kuo, Wen-Ling
   Cheong, David Chon-Fok
   Huang, Jung-Ju
TI The Effect of Negative Pressure on Wound Healing and Regeneration in
   Closed Incisions under High Tension: Evidence from Animal Studies and
   Clinical Experience
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE negative pressure; tensioned wound healing; profunda artery perforator
   flap; breast reconstruction
ID BREAST RECONSTRUCTION; THERAPY; INFLAMMATION; MANAGEMENT; INFECTION;
   SUTURE; FORCES
AB Closed-incision negative-pressure wound therapy (iNPWT) is known to enhance wound healing and tissue regeneration. The main aim of the present study is to investigate its effectiveness on enhancing wound healing under tension. An animal study was designed using a swine model by removing a skin flap to create a wound that could be closed primarily under tension, and iNPWT was applied. The enhancement of angiogenesis, lymphangiogenesis, collagen deposition, and tissue proliferation with reduced inflammation by iNPWT was confirmed by histology. The effect of iNPWT was further verified in patients receiving a profunda artery perforator (PAP) free flap for breast reconstruction. iNPWT was applied on the transversely designed donor site in continuous mode for 7 days, in which the wound was always closed under tension. A significant improvement in off-bed time was noted with the application of iNPWT (4.6 +/- 1.1st and 5.5 +/- 0.8th postoperative days in the iNPWT and control groups, respectively, p = 0.028). The control group (without iNPWT treatment) presented more cases of poor wound healing in the acute (23.1% vs. 0%) and wound breakdown in the late (23.1% vs. 8.3%) stages. The treatment of closed incisions under tension with iNPWT clinically enhances wound healing and tissue regeneration and with histological evidence.
C1 [Hsiao, Hui-Yi; Liu, Jia-Wei; Huang, Jung-Ju] Chang Gung Mem Hosp, Linkou Med Ctr, Ctr Tissue Engn, Taoyuan 333, Taiwan.
   [Hsieh, Wei-Chuan; Cheong, David Chon-Fok; Huang, Jung-Ju] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Linkou Med Ctr,Div Reconstruct Microsurg,Dept Plas, Taoyuan 333, Taiwan.
   [Chang, Frank Chun-Shin] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Dept Plast & Reconstruct Surg,Div Craniofacial Sur, Taoyuan 333, Taiwan.
   [Kuo, Wen-Ling] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Linkou Med Ctr,Div Breast Surg,Dept Surg, Taoyuan 333, Taiwan.
   [Kuo, Wen-Ling; Cheong, David Chon-Fok; Huang, Jung-Ju] Chang Gung Mem Hosp, Breast Canc Ctr, Linkou Med Ctr, Taoyuan 333, Taiwan.
   [Kuo, Wen-Ling] Natl Tsing Hua Univ, Sch Med, Hsinchu 300, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung University; Chang Gung Memorial Hospital; Chang
   Gung University; Chang Gung Memorial Hospital; Chang Gung Memorial
   Hospital; National Tsing Hua University
RP Huang, JJ (通讯作者)，Chang Gung Mem Hosp, Linkou Med Ctr, Ctr Tissue Engn, Taoyuan 333, Taiwan.; Huang, JJ (通讯作者)，Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Linkou Med Ctr,Div Reconstruct Microsurg,Dept Plas, Taoyuan 333, Taiwan.; Huang, JJ (通讯作者)，Chang Gung Mem Hosp, Breast Canc Ctr, Linkou Med Ctr, Taoyuan 333, Taiwan.
EM jungjuhuang@gmail.com
RI ; HSIAO, HUI-YI/K-5428-2017; Cheong, David/LQK-7335-2024
OI Hsieh, Wei-Chuan/0000-0001-8978-7601; HSIAO, HUI-YI/0000-0003-3170-2112;
   Kuo, Wen-Ling/0000-0002-1145-8514
FU Chang Gung Memorial Hospital;  [CMRPG3I0131-2]
FX This work was supported and funded by Chang Gung Memorial Hospital,
   grant numbers CMRPG3I0131-2.
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NR 36
TC 8
Z9 9
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN
PY 2023
VL 12
IS 1
AR 106
DI 10.3390/jcm12010106
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7R0UN
UT WOS:000909795100001
PM 36614907
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Veale, RWF
   Kollmetz, T
   Taghavi, N
   Duston-Fursman, CG
   Beeson, MT
   Asefi, D
   Chittock, HD
   Vikranth, AS
   Dowling, SG
   Dempsey, SG
   Rose, HJ
   Mason, ITT
   May, BCH
AF Veale, Robert W. F.
   Kollmetz, Tarek
   Taghavi, Navid
   Duston-Fursman, Claudia G.
   Beeson, Matthew T.
   Asefi, Dorrin
   Chittock, Henry D.
   Vikranth, Ananth S.
   Dowling, Shane G.
   Dempsey, Sandi G.
   Rose, Hamish J.
   Mason, Isaac T. T.
   May, Barnaby C. H.
TI Influence of advanced wound matrices on observed vacuum pressure during
   simulated negative pressure wound therapy
SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
LA English
DT Article
DE Ovine forestomach matrix; Negative pressure wound therapy; Collagen;
   ORC; Chronic wound; Dermal matrix
ID COLLAGEN EXTRACELLULAR-MATRIX; DIABETIC FOOT ULCER; ASSISTED CLOSURE;
   CLINICAL-OUTCOMES; IN-VITRO; MECHANISM; RECONSTRUCTION; ANGIOGENESIS;
   GROWTH; COST
AB Biomaterials and negative pressure wound therapy (NPWT) are treatment modalities regularly used together to accelerate soft-tissue regeneration. This study evaluated the impact of the design and composition of commer-cially available collagen-based matrices on the observed vacuum pressure delivered under NPWT using a custom test apparatus. Specifically, testing compared the effect of the commercial products; ovine forestomach matrix (OFM), collagen/oxidized regenerated cellulose (collagen/ORC) and a collagen-based dressing (CWD) on the observed vacuum pressure. OFM resulted in an-50% reduction in the observed target vacuum pressure at 75 mmHg and 125 mmHg, however, this effect was mitigated to a-0% reduction when fenestrations were intro-duced into the matrix. Both collagen/ORC and CWD reduced the observed vacuum pressure at 125 mmHg (-15% and-50%, respectively), and this was more dramatic when a lower vacuum pressure of 75 mmHg was delivered (-20% and-75%, respectively). The reduced performance of the reconstituted collagen products is thought to result from the gelling properties of these products that may cause occlusion of the delivered vacuum to the wound bed. These findings highlight the importance of in vitro testing to establish the impact of adjunctive therapies on NPWT, where effective delivery of vacuum pressure is paramount to the efficacy of this therapy.
C1 [Veale, Robert W. F.; Kollmetz, Tarek; Taghavi, Navid; Duston-Fursman, Claudia G.; Beeson, Matthew T.; Asefi, Dorrin; Chittock, Henry D.; Vikranth, Ananth S.; Dowling, Shane G.; Dempsey, Sandi G.; Rose, Hamish J.; Mason, Isaac T. T.; May, Barnaby C. H.] Aroa Biosurg Ltd, Auckland 2022, New Zealand.
RP May, BCH (通讯作者)，Aroa Biosurg Ltd, Auckland 2022, New Zealand.
EM Barnaby.May@aroabio.com
OI Veale, Robert/0000-0002-6534-0167; May, Barnaby/0000-0001-9855-018X;
   Dowling, Shane/0000-0002-7165-5560; Beeson, Matthew/0000-0001-5902-5120;
   Kollmetz, Tarek/0000-0003-4599-7935
FU Aroa Biosurgery Limited; Callaghan Innovation Limited (New Zealand)
   Growth Grant [MSMA1402]
FX This work was supported by Aroa Biosurgery Limited and Callaghan
   Innovation Limited (New Zealand) Growth Grant (MSMA1402).
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NR 54
TC 3
Z9 4
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1751-6161
EI 1878-0180
J9 J MECH BEHAV BIOMED
JI J. Mech. Behav. Biomed. Mater.
PD FEB
PY 2023
VL 138
AR 105620
DI 10.1016/j.jmbbm.2022.105620
EA DEC 2022
PG 8
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 7R2YF
UT WOS:000909942200001
PM 36543083
OA hybrid
DA 2026-07-24
ER
PT J
AU Krupová, L
   Pokorná, A
   Jarosová, D
AF Krupova, L.
   Pokorna, A.
   Jarosova, D.
TI The use of negative pressure wound therapy in a selected medical
   facility
SO CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
LA English
DT Article
DE hospital information system -; negative pressure wound therapy;
   retrospective study&nbsp; wound healing
ID MANAGEMENT
AB Aim: The purpose of study was to analyse the use of negative pressure wound therapy (NPWT) in a selected university hospital in the Czech Republic. Patients and methods: A retrospective non -interventional study. The sample included all records of inpatients treated by NPWT in a selected medical facility (university hospital) in the period from 2015 to 2017. Data was extracted from the university hospital information system. Results: NPWT was reported in 276 hospitalized patients. The mean time of application of NPWT was 19 days (median 10), the average number of dressing changes was 3.74 (median 2), and the exchange interval was once every 2.99 days (median 2.33). Detailed analysis of 2017 showed that in the vast majority of cases the outcome of NPWT treatment was positive (N = 77, 84.62%), in only two cases the effect was not beneficial (2.20%) and rest of cases was not possible to assess clearly (N = 12, 13.19%). Conclusion: NPWT is an effective treatment for wounds of many different aetiologies, but there are differences in its use. As we identified different approaches in application and lack of standardisation, we assume that education of health care providers in this area is a necessary and essential aspect to support the appropriate use of NPWT and for the unification of procedures for the quality of care improvement.
C1 [Krupova, L.] Univ Hosp Ostrava, Dermatol Dept, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.
   [Krupova, L.; Jarosova, D.] Univ Ostrava, Fac Med, Dept Hlth Sci, Ostrava, Czech Republic.
   [Pokorna, A.] Masaryk Univ Brno, Dept Hlth Sci, Brno, Czech Republic.
C3 University Hospital Ostrava; University of Ostrava; Masaryk University
RP Krupová, L (通讯作者)，Univ Hosp Ostrava, Dermatol Dept, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.
EM lenka.krupova@fno.cz
RI Krupová, Lenka/AFO-2325-2022; Pokorná, Andrea/E-5483-2019; Jarosova,
   Darja/D-7464-2014
OI Krupová, Lenka/0000-0003-4834-4614; Pokorná, Andrea/0000-0002-1305-6455;
   
FU student grant competi- tion of the University of Ostrava; 
   [SGS13/LF/2018]
FX Acknowledgement The article relates to the research grant project
   SGS13/LF/2018 - Optimalization of use of NPTW in University hospital
   Ostrava, supported by student grant competi- tion of the University of
   Ostrava.
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   Krupová L, 2019, CESK SLOV NEUROL N, V82, pS40, DOI 10.14735/amcsnn2019S40
   Liu S, 2017, THER CLIN RISK MANAG, V13, DOI 10.2147/TCRM.S131193
   Lone AM, 2014, DIABET FOOT ANKLE, V5, DOI 10.3402/dfa.v5.23345
   Mohseni S, 2019, J DIABETES METAB DIS, V18, P625, DOI 10.1007/s40200-019-00447-6
   Panayi AC, 2017, World Journal of Dermatology, V6, P1, DOI [10.5314/wjd.v6.i1.1, 10.5314/wjd.v6.i1.1, DOI 10.5314/WJD.V6.I1.1]
   Seidel D, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2018-026345
   Vaidhya N, 2015, INDIAN J SURG, V77, pS525, DOI 10.1007/s12262-013-0907-3
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
NR 17
TC 0
Z9 0
U1 0
U2 6
PU CZECH MEDICAL SOC
PI PRAGUE 2
PA SOKOLSKA 31, PRAGUE 2 120 26, CZECH REPUBLIC
SN 1210-7859
EI 1802-4041
J9 CESK SLOV NEUROL N
JI Cesk. Slov. Neurol. Neurochir.
PY 2022
VL 85
SU 1
BP S15
EP S20
DI 10.48095/cccsnn2022S15
PG 6
WC Neurosciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 7R5DH
UT WOS:000910092300001
DA 2026-07-24
ER
PT J
AU Kuril, P
   Mensíková, A
   Búrilová, P
   Saibertová, S
   Pokorná, A
AF Kuril, P.
   Mensikova, A.
   Burilova, P.
   Saibertova, S.
   Pokorna, A.
TI Identification of barriers and benefits of Negative Pressure Wound
   Therapy
SO CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
LA English
DT Article
DE barriers; benefits -; negative pressure&nbsp; wound therapy;
   retrospective analysis; vacuum therapy
AB Aim: This study aimed to identify barriers and benefits of negative pressure wound therapy (NPWT) in patients at the Department of Surgery of the University Hospital Brno over a five-year period (2017-2021). Methods: Retrospective, observational descriptive study of data from hospital records of patients at the Department of Surgery of the University Hospital Brno. Results: A total of 104 patients who were treated with NPWT were identified in the survey. The mean age of the patients was 66.7 years (Min. age 27, Max. age 93). The mean length of hospitalization was 30.2 days (Min. 6, Max. 145 days) and the mean length of NPWT was 20.6 days (Min. 4, Max. 76 days). In total, 31 patients (29.8%) had the same duration of hospitalization and NPWT application and 27 patients (26%) were simultaneously under a barrier regime. The etiology of the wounds was variable. A gastrointestinal disease in 63.4% (N = 66) of patients, vascular problems in 33.7% (N = 35) and pressure ulcers in 2.9% (N = 3). The frequency of wound swabbing was 4 to 6 days and wound dressing (NPWT) exchange was performed in intervals from 3 to 5 days. The VIVANOTec Pro (R) device was used in all patients. Conclusion: A retrospective analysis over a five-year period showed that NPWT is routinely used in wounds of various etiologies, mostly in polymorbid patients of older age. No adverse effects associated with the use of NPWT were documented in the study group.
C1 [Kuril, P.; Mensikova, A.; Burilova, P.; Saibertova, S.; Pokorna, A.] Masaryk Univ, Fac Med, Dept Hlth Sci, Kamenice 3, Brno 62500, Czech Republic.
   [Kuril, P.; Mensikova, A.; Burilova, P.] Masaryk Univ, Fac Med, Dept Publ Hlth, Brno, Czech Republic.
   [Kuril, P.] Univ Hosp Brno, Dept Surg, Brno, Czech Republic.
C3 Masaryk University; Masaryk University; University Hospital Brno
RP Mensíková, A (通讯作者)，Masaryk Univ, Fac Med, Dept Hlth Sci, Kamenice 3, Brno 62500, Czech Republic.
EM burilova@med.muni.cz
RI Pokorná, Andrea/E-5483-2019; Saibertova, Simona/AAO-7873-2021; Búřilová,
   Petra/AAP-8502-2021
OI Pokorná, Andrea/0000-0002-1305-6455; Menšíková,
   Andrea/0000-0001-8548-6051; Saibertova, Simona/0000-0003-2641-9259; 
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Beitz JM, 2012, OSTOMY WOUND MANAG, V58, P50
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   Dumville JC, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011334.pub2
   Hokynková A, 2017, CESK SLOV NEUROL N, V80, pS41, DOI 10.14735/amcsnn2017S41
   Iheozor-Ejiofor Z, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012522.pub2
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Matiasek J, 2018, PLAST AESTHET RES, V5, P36, DOI [10.20517/2347-9264.2018.50, DOI 10.20517/2347-9264.2018.50]
   Mervis JS, 2019, J AM ACAD DERMATOL, V81, P893, DOI 10.1016/j.jaad.2018.12.068
   Norman G, 2020, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD009261.pub6, 10.1002/14651858.CD009261.pub5]
   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Pokorna A., 2012, UVOD WOUND MANAGEMEN
   Rezk F, 2019, CONT CLIN TRIAL COMM, V16, DOI 10.1016/j.conctc.2019.100469
   Simek M, 2013, PODTLAKOVA LECBA RAN
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
NR 16
TC 0
Z9 0
U1 0
U2 7
PU CZECH MEDICAL SOC
PI PRAGUE 2
PA SOKOLSKA 31, PRAGUE 2 120 26, CZECH REPUBLIC
SN 1210-7859
EI 1802-4041
J9 CESK SLOV NEUROL N
JI Cesk. Slov. Neurol. Neurochir.
PY 2022
VL 85
SU 1
DI 10.48095/cccsnn2022S43
PG 4
WC Neurosciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 7R5DM
UT WOS:000910092800001
DA 2026-07-24
ER
PT J
AU Meyer, J
   Roos, E
   Abbassi, Z
   Toso, C
   Buchs, CN
   Ris, F
AF Meyer, Jeremy
   Roos, Elin
   Abbassi, Ziad
   Toso, Christian
   Buchs, Christian Nicolas
   Ris, Frederic
TI Does prophylactic negative pressure wound therapy prevent surgical site
   infection in abdominal surgery?
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE abdominal surgery; PICO; Prevena; prophylactic; negative pressure wound
   therapy; SSI; surgical site infection; VAC; vacuum assisted closure;
   wound; wound care; wound dressing; wound healing
ID LAPAROTOMY INCISIONS; GENERAL-SURGERY; OUTCOMES; TRIAL
AB Objective: To determine if prophylactic negative pressure wound therapy (pNPWT) allows for the prevention of surgical site infections (SSIs) in abdominal surgery.
   Method: A non-systematic review assessing the evidence was conducted in 2020.
   Results: Retrospectve studies comparing patients with pNPWT with patients receiving standard wound dressing after abdominal surgery showed encouragning results in favour of pNPWT for reducing the incidence of SSIs, but randomised controlled trials have so far reported mixed results.
   Conclusion: New randomised controlled trials including a sufficient number of patients at risk of SSIs are needed for confirming the results of non-interventional studies.
C1 [Meyer, Jeremy; Abbassi, Ziad; Toso, Christian; Buchs, Christian Nicolas; Ris, Frederic] Univ Hosp Geneva, Div Digest Surg, CH-1211 Geneva 14, Switzerland.
   [Roos, Elin] Karolinska Inst, Dept Publ Hlth Sci, SE-17177 Stockholm, Sweden.
C3 University of Geneva; Karolinska Institutet
RP Meyer, J (通讯作者)，Univ Hosp Geneva, Div Digest Surg, CH-1211 Geneva 14, Switzerland.
EM jeremy.meyer@hcuge.ch
RI Abbassi, Ziad/HZL-6239-2023; Meyer, Jeremy/AAP-3367-2020; Ris,
   Frederic/H-7030-2019; Toso, Christian/E-7785-2018
OI Meyer, Jeremy/0000-0003-3381-9146; Ris, Frederic/0000-0001-7421-6101;
   Toso, Christian/0000-0003-1652-4522
CR Allegranzi Benedetta, 2016, Lancet Infect Dis, V16, pe276, DOI [10.1016/s1473-3099(16)30402-9, 10.1016/s1473-3099(16)30398-x, 10.1016/S1473-3099(16)30398-X]
   Badia JM, 2017, J HOSP INFECT, V96, P1, DOI 10.1016/j.jhin.2017.03.004
   Blackham AU, 2013, AM J SURG, V205, P647, DOI 10.1016/j.amjsurg.2012.06.007
   Bonds AM, 2013, DIS COLON RECTUM, V56, P1403, DOI 10.1097/DCR.0b013e3182a39959
   Burkhart RA, 2017, HPB, V19, P825, DOI 10.1016/j.hpb.2017.05.004
   Chadi SA, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0817-8
   Condé-Green A, 2013, ANN PLAS SURG, V71, P394, DOI 10.1097/SAP.0b013e31824c9073
   Curran T, 2019, COLORECTAL DIS, V21, P110, DOI 10.1111/codi.14350
   Donlon NE, 2019, INT J COLORECTAL DIS, V34, P2003, DOI 10.1007/s00384-019-03398-9
   Gassman A, 2015, HERNIA, V19, P273, DOI 10.1007/s10029-014-1312-y
   HORAN TC, 1992, AM J INFECT CONTROL, V20, P271, DOI 10.1016/S0196-6553(05)80201-9
   Javed AA, 2019, ANN SURG, V269, P1034, DOI 10.1097/SLA.0000000000003056
   Kuncewitch MP, 2019, AM SURGEON, V85, P1
   Kuper TM, 2020, ANN SURG, V271, P67, DOI 10.1097/SLA.0000000000003435
   Li PY, 2017, SCAND J SURG, V106, P189, DOI 10.1177/1457496916668681
   Mahmoud NN, 2009, SURG INFECT, V10, P539, DOI 10.1089/sur.2009.006
   Mehdorn M, 2020, ACTA CHIR BELG, V120, P250, DOI 10.1080/00015458.2019.1599180
   Meyer J, 2021, INT J COLORECTAL DIS, V36, P19, DOI 10.1007/s00384-020-03732-6
   Mihaljevic AL, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0995-4
   Murphy PB, 2019, ANN SURG, V270, P38, DOI 10.1097/SLA.0000000000003111
   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
   Pellino G, 2014, INT J SURG, V12, pS64, DOI 10.1016/j.ijsu.2014.08.378
   Roos E, 2021, ANN SURG, V274, pE698, DOI 10.1097/SLA.0000000000003841
   Sahebally SM, 2018, JAMA SURG, V153, DOI 10.1001/jamasurg.2018.3467
   Schurtz E, 2018, AM J SURG, V215, P113, DOI 10.1016/j.amjsurg.2017.08.009
   Selvaggi Francesco, 2014, Surg Technol Int, V24, P83
   Shen P, 2017, J AM COLL SURGEONS, V224, P726, DOI 10.1016/j.jamcollsurg.2016.12.028
   SUNRRISE Study Group on behalf of the Northwest Research Collaborative and the West Midlands Research Collaborative, 2020, Colorectal Dis, DOI 10.1111/codi.15474
   Urban Joshua A, 2006, Surg Infect (Larchmt), V7 Suppl 1, pS19, DOI 10.1089/sur.2006.7.s1-19
   Webb MA, 2019, AM J SURG, V217, P948, DOI 10.1016/j.amjsurg.2018.12.019
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
   Zaidi A, 2017, COLORECTAL DIS, V19, P283, DOI 10.1111/codi.13458
   Zwanenburg PR, 2020, ANN SURG, V272, P81, DOI 10.1097/SLA.0000000000003644
NR 33
TC 0
Z9 0
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2023
VL 32
IS 1
SU S
BP S28
EP S34
DI 10.12968/jowc.2023.32.Sup1.S28
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 7S6IG
UT WOS:000910855000005
PM 36630193
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Shikara, M
   Waghmarae, S
   Vakharia, KT
AF Shikara, Meryam
   Waghmarae, Suneet
   Vakharia, Kalpesh T.
TI Closure of a Large Scalp Defect Using External Tissue Expansion
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE DermaClose; external tissue expanders; scalp defects; scalp
   reconstruction; reconstructive surgery
AB The limited laxity of the scalp and hair-bearing nature makes it difficult to optimally repair. Primary closure is limited to small defects, while healing by secondary intention requires underlying periosteum. Furthermore, the use of free flaps and skin grafting can lead to unfavorable cosmetic outcomes. This report describes a patient with a large parietal scalp dermatofibrosarcoma protuberans. Multiple resections resulted in a large scalp defect with exposed calvarium. Integra was placed over the exposed calvarium after each debridement and Negative Pressure Wound Therapy (NPWT) was applied. After granulation tissue formed, 2 DermaClose continuous external tissue expansion systems were installed. Following the application and tightening of the external tissue expanders, the wound was reduced in size, facilitating primary closure of the opposing edges. This process allowed for a large area to be covered with hair-bearing scalp with good cosmetic results.
C1 [Shikara, Meryam; Vakharia, Kalpesh T.] Univ Maryland Med Syst, Dept Otorhinolaryngol Head & Neck Surg, Baltimore, MD USA.
   [Waghmarae, Suneet; Vakharia, Kalpesh T.] Univ Maryland, Sch Med, Baltimore, MD USA.
   [Shikara, Meryam] Dept Otorhinolaryngol Head & Neck Surg, 16 South Eutaw St,Suite 500, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore
RP Shikara, M (通讯作者)，Dept Otorhinolaryngol Head & Neck Surg, 16 South Eutaw St,Suite 500, Baltimore, MD 21201 USA.
EM mshikara@som.umaryland.edu; suneet.waghmarae@som.umaryland.edu;
   kvakharia@som.umaryland.edu
CR Bajoghli AA, 2010, J DRUGS DERMATOL, V9, P149
   Lasheen Ahmed E, 2009, J Plast Reconstr Aesthet Surg, V62, pe251, DOI 10.1016/j.bjps.2007.05.019
   MacKay BJ, 2020, ADV WOUND CARE, V9, P525, DOI 10.1089/wound.2019.1112
   Mangubat EA, 2013, FACIAL PLAST SURG CL, V21, P487, DOI 10.1016/j.fsc.2013.05.006
   O'Reilly AG, 2012, ARCH FACIAL PLAST S, V14, P419, DOI 10.1001/archfacial.2012.662
NR 5
TC 2
Z9 2
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD JAN-FEB
PY 2023
VL 34
IS 1
DI 10.1097/SCS.0000000000008911
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 7T2RZ
UT WOS:000911295400022
PM 35968971
DA 2026-07-24
ER
PT J
AU Tang, D
   Liu, CM
   Chen, X
   Lv, X
   Yuan, LL
   Xue, DD
   Song, HP
AF Tang, Di
   Liu, Chunmei
   Chen, Xia
   Lv, Xian
   Yuan, Lili
   Xue, Dongdong
   Song, Huapei
TI The associations between diode laser (810 nm) therapy and chronic wound
   healing and pain relief: Light into the chronic wound patient's life
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE chronic wound; diode laser therapy; pain relief index; wound healing
   time
ID OPTICAL-PROPERTIES; SKIN; BURN; RED
AB Chronic wounds have become one of the major issues in medicine today, the treatments for which include dressing changes, negative pressure wound therapy, hyperbaric oxygen, light irradiation, surgery and so forth. Nevertheless, the application of diode lasers in chronic wounds has rarely been reported. This retrospective cohort study aimed to evaluate the therapeutic effect of diode laser (810 nm) irradiation on chronic wounds. Eighty-nine patients were enrolled in the study. The control group (41 patients) received traditional dressing change therapy, while the diode laser treatment group (48 patients) were patients received additional treatment with diode laser (810 nm) irradiation for 10 min at each dressing change. Wound healing time was compared between two groups, while the pain relief index was creatively introduced to evaluate the effect of relieving wound pain, which was calculated by the difference in pain scores between the first and last dressing changes divided by the number of treatment days. The wound healing time of the diode laser treatment group was 22.71 +/- 8.99 days, which was significantly shorter than that of the control group (37.44 +/- 23.42 days). The pain relief index of the diode laser treatment group was 0.081 +/- 0.055, which was significantly increased compared with that of the control group (0.057 +/- 0.033). Our findings suggest that diode laser irradiation has the potential to promote healing in chronic wounds and relieve wound pain.
C1 [Tang, Di; Liu, Chunmei; Chen, Xia; Lv, Xian; Yuan, Lili; Xue, Dongdong; Song, Huapei] Army Med Univ, Southwest Hosp, Inst Burn Res, State Key Lab Trauma Burns & Combined Injury, Chongqing, Peoples R China.
   [Tang, Di] Gen Hosp Cent Theater Command, Burn & Plast Surg Dept, Wuhan, Hubei, Peoples R China.
   [Xue, Dongdong] Army Med Univ, Southwest Hosp, Inst Burn Res, State Key Lab Trauma Burns & Combined Injury, Chongqing 400038, Peoples R China.
C3 Army Medical University; Army Medical University
RP Xue, DD (通讯作者)，Army Med Univ, Southwest Hosp, Inst Burn Res, State Key Lab Trauma Burns & Combined Injury, Chongqing 400038, Peoples R China.
EM xuedongdong@tmmu.edu.cn; shpmajor@tmmu.edu.cn
OI Xue, Dongdong/0000-0003-2732-8316; Tang, Di/0000-0001-6052-578X
FU Chongqing Science and Technology Commission [cstc2018jscx-msybX0112];
   Natural Science Foundation of Hubei Province [2021CFB164]; Project of
   the State Key Laboratory of Trauma, Burn and Combined Injury, Third
   Military Medical University [SKLJYJF19]; Postdoctoral Fund of Central
   Theater General Hospital [BSH017]
FX Chongqing Science and Technology Commission, Grant/Award Number:
   cstc2018jscx-msybX0112; Natural Science Foundation of Hubei Province,
   Grant/Award Number: 2021CFB164; Project of the State Key Laboratory of
   Trauma, Burn and Combined Injury, Third Military Medical University,
   Grant/Award Number: SKLJYJF19; Postdoctoral Fund of Central Theater
   General Hospital, Grant/Award Number: BSH017
CR Bairagi A, 2019, BURNS TRAUMA, V7, DOI 10.1186/s41038-019-0165-0
   Bjordal JM, 2006, PHOTOMED LASER SURG, V24, P158, DOI 10.1089/pho.2006.24.158
   Chow RT, 2009, LANCET, V374, P1897, DOI 10.1016/S0140-6736(09)61522-1
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   Dancáková L, 2014, PHOTOMED LASER SURG, V32, P198, DOI 10.1089/pho.2013.3586
   Farias RD, 2016, ANGLE ORTHOD, V86, P193, DOI 10.2319/122214-933.1
   Gupta A, 2014, LASER MED SCI, V29, P257, DOI 10.1007/s10103-013-1319-0
   Gupta A, 2013, BIOTECHNOL ADV, V31, P607, DOI 10.1016/j.biotechadv.2012.08.003
   Han CM, 2020, BURNS TRAUMA, V8, DOI 10.1093/burnst/tkaa035
   Han G, 2017, ADV THER, V34, P599, DOI 10.1007/s12325-017-0478-y
   Holzer AM, 2010, J INVEST DERMATOL, V130, P1496, DOI 10.1038/jid.2010.79
   Huss MK, 2019, COMPARATIVE MED, V69, P535, DOI 10.30802/AALAS-CM-19-000013
   Jacques SL, 2013, PHYS MED BIOL, V58, pR37, DOI 10.1088/0031-9155/58/11/R37
   Ji SZ, 2021, BURNS TRAUMA, V9, DOI 10.1093/burnst/tkab018
   Sabino CP, 2016, J PHOTOCH PHOTOBIO B, V160, P72, DOI 10.1016/j.jphotobiol.2016.03.047
   Schreml S, 2010, BRIT J DERMATOL, V163, P257, DOI 10.1111/j.1365-2133.2010.09804.x
   Silveira PCL, 2016, INFLAMMATION, V39, P1395, DOI 10.1007/s10753-016-0371-x
   Snelgrove Helen, 2019, Br J Community Nurs, V24, pS12, DOI [10.12968/bjcn.2019.24.sup12.s12, 10.12968/bjcn.2019.24.Sup12.S12]
   Turhani D, 2006, AM J ORTHOD DENTOFAC, V130, P371, DOI 10.1016/j.ajodo.2005.04.036
   Wang ZW, 2020, BURNS TRAUMA, V8, DOI 10.1093/burnst/tkaa021
   Weller CD, 2020, WOUND REPAIR REGEN, V28, P211, DOI 10.1111/wrr.12773
   Woo Kevin Y, 2012, Surg Technol Int, V22, P57
   Xu PC, 2020, BURNS TRAUMA, V8, DOI 10.1093/burnst/tkaa028
   Yadav A, 2017, PHOTODERMATOL PHOTO, V33, P4, DOI 10.1111/phpp.12282
   Yamakawa S, 2019, BURNS TRAUMA, V7, DOI 10.1186/s41038-019-0148-1
NR 26
TC 5
Z9 6
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR
PY 2023
VL 31
IS 2
BP 227
EP 232
DI 10.1111/wrr.13066
EA JAN 2023
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA I0TG6
UT WOS:000912201100001
PM 36541709
DA 2026-07-24
ER
PT J
AU Suter, KJL
   Fairweather, L
   Al-Habbal, Y
   Houli, N
   Jacobs, R
   Bui, HT
AF Suter, Katherine J. L.
   Fairweather, Luke
   Al-Habbal, Yayha
   Houli, Nezor
   Jacobs, Rodney
   Bui, Hai T.
TI How to isolate a high output enteroatmospheric fistula in the open
   abdomen with negative pressure therapy: an institution's step by step
   guide to the VAC donut
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE enteroatmospheric fistula; fistula donut; negative pressure wound
   therapy; open abdomen; VAC donut
ID WOUND THERAPY; MANAGEMENT; SEPSIS
AB There is multiple evidence to suggest that isolation techniques of high output enteroatmospheric fistulas (EAF) in open abdomens can be advantageous in controlling fistula effluent while allowing time for abdominal wall to granulate. The large loss of proteins, electrolytes and fluid, and the distressing nature of the open abdomen for both patients and doctors, make managing these EAFs a clinical challenge. We present our experience with a high output mucosal protruding EAF and the creation of a 'VAC donut' allowing a successful diversion of the enteric content whilst promoting granulation of the tissue bed.
C1 [Suter, Katherine J. L.; Fairweather, Luke; Al-Habbal, Yayha; Houli, Nezor; Jacobs, Rodney; Bui, Hai T.] Western Hlth, Dept Upper Gastrointestinal & Gen Surg, Melbourne, Vic, Australia.
   [Suter, Katherine J. L.] Western Hlth, Dept Upper GI & Gen Surg, 160 Gordon St, Melbourne, Vic 3011, Australia.
C3 Western Health; Western Health
RP Suter, KJL (通讯作者)，Western Hlth, Dept Upper GI & Gen Surg, 160 Gordon St, Melbourne, Vic 3011, Australia.
EM suterkj@gmail.com
OI Suter, Katherine/0000-0003-0945-3690; Fairweather,
   Luke/0000-0002-0932-5667; jacobs, rodney/0000-0002-8757-7122
CR BERRY SM, 1994, CURR PROB SURG, V31, P474
   Bobkiewicz A, 2017, INT WOUND J, V14, P255, DOI 10.1111/iwj.12597
   Cirocchi R, 2016, J TRAUMA ACUTE CARE, V81, P575, DOI 10.1097/TA.0000000000001126
   Connolly PT, 2008, ANN SURG, V247, P440, DOI 10.1097/SLA.0b013e3181612c99
   Davis KG, 2013, SURG CLIN N AM, V93, P231, DOI 10.1016/j.suc.2012.09.009
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NR 23
TC 3
Z9 5
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD MAR
PY 2023
VL 93
IS 3
BP 682
EP 686
DI 10.1111/ans.18270
EA JAN 2023
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A6JN3
UT WOS:000912807100001
PM 36629275
OA Bronze
DA 2026-07-24
ER
PT J
AU Wu, MF
   Matar, DY
   Yu, Z
   Chen, ZY
   Knoedler, S
   Ng, B
   Darwish, O
   Haug, V
   Friedman, L
   Orgill, DP
   Panayi, AC
AF Wu, Mengfan
   Matar, Dany Y.
   Yu, Zhen
   Chen, Ziyu
   Knoedler, Samuel
   Ng, Brian
   Darwish, Oliver
   Haug, Valentin
   Friedman, Leigh
   Orgill, Dennis P.
   Panayi, Adriana C.
TI Modulation of Lymphangiogenesis in Incisional Murine Diabetic Wound
   Healing Using Negative Pressure Wound Therapy
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE wound healing; incisional wound; NPWT; negative pressure wound therapy;
   lymphatics; lymphangiogenesis; diabetic wound; tissue regeneration
ID VACUUM-ASSISTED CLOSURE; LYMPHATIC-SYSTEM; MANAGEMENT; INFLAMMATION;
   VEGF
AB Objective: Despite the significant function of lymphatics in wound healing, and frequent clinical use of Negative Pressure Wound Therapy (NPWT), the effect of mechanical force application on lymphangiogenesis remains to be elucidated. We utilize a murine incisional wound healing model to assess the mechanisms of lymphangiogenesis following NPWT.Approach: Dorsal incisional skin wounds were created on diabetic mice (genetically obese leptin receptor-deficient mice [db/db]; n = 30) and covered with an occlusive dressing (Control, n = 15) or NPWT (-125 mmHg, continuous, 24 h for 7 days; NPWT, n = 15). The wounds were macroscopically assessed for 28 days. Tissue was harvested on day 10 for analysis. Qualitative functional analysis of lymphatic drainage was performed on day 28 using Evans Blue staining (n = 2).Results: NPWT increased lymphatic vessel density (40 +/- 20 vs. 12 +/- 6 podoplanin [PDPN](+) and 25 +/- 9 vs. 14 +/- 8 lymphatic vessel endothelial receptor 1 [LYVE-1](+)) and vessel diameter (28 +/- 9 vs. 12 +/- 2 mu m). Western blotting verified the upregulation of LYVE-1 with NPWT. Leukocyte presence was higher with NPWT (22% +/- 3.7% vs. 9.1% +/- 4.1% lymphocyte common antigen [CD45](+)) and the leukocytes were predominately B cells clustered within vessels (8.8% +/- 2.5% vs. 18% +/- 3.6% B-lymphocyte antigen CD20 [CD20](+)). Macrophage presence was lower in the NPWT group. Lymphatic drainage was increased in the NPWT group, which exhibited greater Evans Blue positivity.Innovation: The lymphangiogenic effects take place independent of macrophage infiltration, appearing to correlate with B cell presence.Conclusion: NPWT promotes lymphangiogenesis in incisional wounds, significantly increasing the lymph vessel density and diameter. This study highlights the potential of NPWT to stimulate lymphatic drainage and wound healing of surgical incisions.
C1 [Wu, Mengfan; Matar, Dany Y.; Chen, Ziyu; Knoedler, Samuel; Ng, Brian; Darwish, Oliver; Haug, Valentin; Friedman, Leigh; Orgill, Dennis P.; Panayi, Adriana C.] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA USA.
   [Wu, Mengfan] Peking Univ Shenzhen Hosp, Dept Plast Surg, Shenzhen, Peoples R China.
   [Matar, Dany Y.] Washington Univ St Louis, Dept Med, St Louis, MO USA.
   [Yu, Zhen] Jinan Univ, Shenzhen Eye Hosp, Opthalmol Dept, Shenzhen Key Ophthalm Lab, Shenzhen, Peoples R China.
   [Yu, Zhen] Harvard Med Sch, Massachusetts Eye & Ear Infirm, Ophthalmol Dept, Angiogenesis Lab, Boston, MA USA.
   [Knoedler, Samuel] Tech Univ Munich, Dept Plast Surg & Hand Surg, Klinikum Rechts Isar, Munich, Germany.
   [Ng, Brian] St Louis Univ, Dept Med, Sch Med, St Louis, MO USA.
   [Darwish, Oliver] Calif Northstate Univ, Dept Med, Coll Med, Elk Grove, CA USA.
   [Haug, Valentin; Panayi, Adriana C.] Heidelberg Univ, Burn Ctr, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg,Microsurg, Ludwigshafen, Germany.
   [Friedman, Leigh] Lehigh Univ, Dept Med, Bethlehem, PA USA.
   [Friedman, Leigh] Drexel Univ, Coll Med, Dept Med, 75 Francis St, Philadelphia, PA USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Peking University; Washington
   University (WUSTL); Jinan University; Shenzhen Eye Hospital; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts Eye & Ear Infirmary; Technical University of
   Munich; Saint Louis University; Ruprecht Karls University Heidelberg;
   Lehigh University; Drexel University
RP Panayi, AC (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, Dept Surg, 75 Francis St, Boston, MA 02115 USA.; Panayi, AC (通讯作者)，Harvard Med Sch, 75 Francis St, Boston, MA 02115 USA.
EM apanayi@bwh.harvard.edu
RI Panayi, Adriana/HHT-0513-2022; Orgill, Dennis/H-7596-2019; Knoedler,
   Samuel Alfons/IZQ-4210-2023; Haug, Valentin/ADF-7566-2022
OI Panayi, Adriana/0000-0003-4053-9855; Orgill, Dennis/0000-0002-8279-7310;
   Matar, Dany/0000-0001-7108-0413; Knoedler, Samuel
   Alfons/0000-0001-5798-8003; Yu, Zhen/0000-0003-3456-3584; Wu,
   Mengfan/0000-0003-2646-3372; Chen, Ziyu/0000-0001-5562-7554
FU NIH [5 T35 HL11084]; Gillian Reny Stepping Strong Center for Trauma
   Innovation award; 3M+KCI award
FX This work is funded, in part, by NIH 5 T35 HL11084 fellowship award to
   L.F., and a Gillian Reny Stepping Strong Center for Trauma Innovation
   award and 3M+KCI award to D.P.O.
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NR 44
TC 7
Z9 8
U1 2
U2 17
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD SEP 1
PY 2023
VL 12
IS 9
BP 483
EP 497
DI 10.1089/wound.2022.0074
EA JAN 2023
PG 15
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA J5HH1
UT WOS:000913068800001
PM 36424821
DA 2026-07-24
ER
PT J
AU He, R
   Li, XY
   Xie, K
   Wen, B
   Qi, X
AF He, Rui
   Li, Xiangyan
   Xie, Kun
   Wen, Bing
   Qi, Xin
TI Characteristics of Fournier gangrene and evaluation of the effects of
   negative-pressure wound therapy
SO FRONTIERS IN SURGERY
LA English
DT Article
DE Fournier gangrene; negative-pressure wound therapy; necrotizing
   fasciitis; microbiology; treatment
ID MORTALITY
AB Fournier gangrene (FG) is a life-threatening disease affecting the soft tissues of the genital, perineal, and perianal regions. This retrospective study aimed to summarize the characteristics of FG and evaluate the effects of negative-pressure wound therapy (NPWT). We analyzed clinical data of 36 patients with FG admitted to our department. Thirty-four cases had perianal and external genital infections, and the other two had secondary infection of the urinary fistula after trauma and retroperitoneal abscess, respectively. Monomicrobial, polymicrobial, culture-negative, and fungal infections were identified in 16, 17, 2, and 1 cases, respectively. Escherichia coli, Enterococcus faecalis, Enterococcus faecium, Klebsiella pneumoniae, and Staphylococcus haemolyticus were the most common pathogens. The mortality rate was 8%. Twenty-seven and nine patients were treated with NPWT (group A) and conventional dressing (group B), respectively. The length of stay was 38.0 +/- 16.1 and 51.0 +/- 17.3 days, number of operations were 3 (3,6) and 13 (4,17), and wound healing times were 39.2 +/- 18.1 and 66.5 +/- 17.1 days in groups A and B, respectively. Taken together, clinicians should always consider the possibility of perianal or external genital infections progressing to FG in the daily work, especially for patients with diabetes mellitus. Enterobacteriaceae, Enterococcus, and Staphylococcus haemolyticus are the most common causative pathogens, and NPWT is an effective adjuvant therapy for wound management with fewer operations and a shorter wound healing time.
C1 [He, Rui; Xie, Kun; Wen, Bing; Qi, Xin] Peking Univ First Hosp, Dept Plast Surg & Burn, Beijing, Peoples R China.
   [Li, Xiangyan] Peking Univ First Hosp, Inst Clin Pharmacol, Dept Antiinfect, Beijing, Peoples R China.
RP Qi, X (通讯作者)，Peking Univ First Hosp, Dept Plast Surg & Burn, Beijing, Peoples R China.
EM 04983@pkufh.com
RI ; Qi, Xin/O-5922-2019
OI Kun, Xie/0009-0006-5903-619X; Qi, Xin/0000-0003-1124-2374
FU Youth Clinical Research Project of the Peking University First Hospital
   [2017CR13]
FX Funding This study was supported by the Youth Clinical Research Project
   of the Peking University First Hospital (grant no. 2017CR13).
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NR 12
TC 5
Z9 6
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JAN 6
PY 2023
VL 9
AR 1075968
DI 10.3389/fsurg.2022.1075968
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 7X0GU
UT WOS:000913884100001
PM 36684293
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Biermann, N
   Wallner, S
   Martini, T
   Spoerl, S
   Prantl, L
   Taeger, CD
AF Biermann, Niklas
   Wallner, Stefan
   Martini, Teresa
   Spoerl, Steffen
   Prantl, Lukas
   Taeger, Christian D. D.
TI Negative Pressure Wound Therapy with Instillation: Analysis of the
   Rinsing Fluid as a Monitoring Tool and Approach to the Inflammatory
   Process: A Pilot Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE negative pressure wound therapy with instillation; inflammation; wound
   healing
ID VACUUM-ASSISTED CLOSURE; CLEARANCE
AB Background: Negative pressure wound therapy with instillation (NPWTi) is an established wound conditioning tool. Previous investigations discovered that the rinsing fluid is a suitable monitoring tool containing various cells and cytokines. Methods: The aim of this pilot study was to analyze rinsing fluid samples from patients treated with NPWTi and link them to the clinical course, including microbiological contamination. In 31 consecutive patients with acute and chronic wounds, laboratory analysis was performed to evaluate IL-6, IL-8, bFGF, Tnf-a, and VEGF. Results: IL-6 showed a significant increase to 1540 pg/mL on day two and 860 pg/mL on day four (p = 0.01 and p = 0.04, resp.). IL-8 steadily increased from a median of 2370 pg/mL to a maximum of 19,400 pg/mL on day three (p = 0.01). The median bFGF showed a steady decline from 22 pg/mL to 10 pg/m (p = 0.35) on day three. The median Tnf-a increased from 11 pg/mL to 44 pg/mL (p = 001). The median VEGF values fluctuated but showed an overall increase from 35 pg/mL to 250 pg/mL (p = 0.07). Regarding IL-8, diabetic and non-diabetic patients both showed a gradual increase with non-significant higher median values for the diabetics. The subgroup analysis of IL-6 showed increasing and higher values in cases with bacterial superinfections (p = 0.07). Conclusion: We were able to use an established wound conditioning tool to gather important information about the inflammatory response during NPWTi treatment. Cytokine and cell courses were mostly consistent with the literature, especially in diabetic patients, and should be further investigated.
C1 [Biermann, Niklas; Martini, Teresa; Prantl, Lukas; Taeger, Christian D. D.] Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, D-93053 Regensburg, Germany.
   [Wallner, Stefan] Univ Hosp Regensburg, Dept Clin Chem, D-93053 Regensburg, Germany.
   [Spoerl, Steffen] Univ Hosp Regensburg, Clin & Polyclin Oral & Maxillofacial Surg, D-93053 Regensburg, Germany.
C3 University of Regensburg; University of Regensburg; University of
   Regensburg
RP Biermann, N (通讯作者)，Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, D-93053 Regensburg, Germany.
EM niklas.biermann@ukr.de
RI prantl, Lukas/AAM-1848-2021
OI prantl, Lukas/0000-0003-2454-2499
FU Manfred Roth Stiftung [n.a] Funding Source: Medline
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NR 29
TC 2
Z9 3
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN
PY 2023
VL 12
IS 2
AR 711
DI 10.3390/jcm12020711
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7Z3XS
UT WOS:000915496500001
PM 36675638
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yamashiro, T
   Kushibiki, T
   Mayumi, Y
   Tsuchiya, M
   Ishihara, M
   Azuma, R
AF Yamashiro, Toshifumi
   Kushibiki, Toshihiro
   Mayumi, Yoshine
   Tsuchiya, Masato
   Ishihara, Miya
   Azuma, Ryuichi
TI Novel cell culture system for monitoring cells during continuous and
   variable negative-pressure wound therapy
SO SKIN RESEARCH AND TECHNOLOGY
LA English
DT Article
DE epithelial-to-mesenchymal transition; intermittent negative-pressure
   wound therapy; keratinocyte; microdeformational wound therapy;
   negative-pressure incubator; topical negative pressure; vacuum-assisted
   closure; wound healing
ID VACUUM-ASSISTED CLOSURE
AB BackgroundAlthough the clinical efficacy of negative-pressure wound therapy (NPWT) is well known, many of its molecular biological mechanisms remain unresolved, mainly due to the difficulty and paucity of relevant in vitro studies. We attempted to develop an in vitro cell culture system capable of real-time monitoring of cells during NPWT treatment. Materials and methodsA novel negative-pressure cell culture system was developed by combining an inverted microscope, a stage-top incubator, a sealed metal chamber for cell culture, and an NPWT treatment device. Human keratinocytes, PSVK-1, were divided into ambient pressure (AP), continuous negative-pressure (NPc), and intermittent negative-pressure (NPi) groups and cultured for 24 h with scratch assay using our real-time monitoring system and device. Pressure inside the device, medium evaporation rate, and the residual wound area were compared across the groups. ResultsPressure in the device was maintained at almost the same value as set in all groups. Medium evaporation rate was significantly higher in the NPi group than in the other two groups; however, it had negligible effect on cell culture. Residual wound area after 9 h evaluated by the scratch assay was significantly smaller in the NPc and NPi groups than in the AP group. ConclusionWe developed a negative-pressure cell culture device that enables negative-pressure cell culture under conditions similar to those used in clinical practice and is able to monitor cells under NPWT. Further experiments using this device would provide high-quality molecular biological evidence for NPWT.
C1 [Yamashiro, Toshifumi; Tsuchiya, Masato; Azuma, Ryuichi] Natl Def Med Coll, Dept Plast & Reconstruct Surg, Saitama, Japan.
   [Kushibiki, Toshihiro; Mayumi, Yoshine; Ishihara, Miya] Natl Def Med Coll, Dept Med Engn, Saitama, Japan.
   [Kushibiki, Toshihiro] Natl Def Med Coll, Dept Med Engn, 3-2 Namiki,Tokorozawa, Saitama, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan; National Defense Medical College - Japan
RP Kushibiki, T (通讯作者)，Natl Def Med Coll, Dept Med Engn, 3-2 Namiki,Tokorozawa, Saitama, Japan.
EM toshi@ndmc.ac.jp
RI Azuma, Ryuichi/AAT-1125-2021; Yamashiro, Toshifumi/JJE-7945-2023
OI Kushibiki, Toshihiro/0000-0002-1705-1467; Yamashiro,
   Toshifumi/0000-0001-7019-7740
FU JSPS KAKENHI [20K12725]; Grants-in-Aid for Scientific Research
   [20K12725] Funding Source: KAKEN
FX ACKNOWLEDGMENTS This study was partially supported by JSPS KAKENHI grant
   number: 20K12725. We would like to thank Editage () for English language
   editing.
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NR 45
TC 6
Z9 7
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0909-752X
EI 1600-0846
J9 SKIN RES TECHNOL
JI Skin Res. Technol.
PD JAN
PY 2023
VL 29
IS 1
AR e13262
DI 10.1111/srt.13262
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 8C4NF
UT WOS:000917586300001
PM 36704879
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Mehkri, Y
   Hernandez, J
   Panther, E
   Gendreau, J
   Pafford, R
   Rao, DE
   Fiester, P
   Rahmathulla, G
AF Mehkri, Yusuf
   Hernandez, Jairo
   Panther, Eric
   Gendreau, Julian
   Pafford, Ryan
   Rao, Dinesh
   Fiester, Peter
   Rahmathulla, Gazanfar
TI Incisional Wound Vacuum-Evaluation of Wound Outcomes in Comparison With
   Standard Dressings for Posterior Spinal Fusions in Traumatic Patients
SO OPERATIVE NEUROSURGERY
LA English
DT Article
DE Incisional wound vacuum; Negative pressure wound therapy; Posterior
   spinal fusion; Standard dressing; Surgical site infection
ID SURGICAL SITE INFECTION; ASSISTED CLOSURE; RISK-FACTORS; THERAPY;
   DEHISCENCE; SURGERY
AB BACKGROUND:Postoperative incisional negative pressure wound vacuum-assisted closure (VAC) dressings are being used as a primary dressing to optimize wound healing and help avoid complications of infection and dehiscence. Few studies have investigated whether application of VAC dressings on postoperative posterior spinal wounds can reduce the incidence of surgical site infections.OBJECTIVE:To describe our single-surgeon experience of using primary VAC after posterior spinal fusion (PSF) in a large sample of trauma patients.METHODS:This was an Institutional Review Board-approved retrospective comparative study and included all trauma patients presenting to our level 1 safety-net trauma center who required PSF and were operated on by the senior surgeon between 2016 and 2021. Primary outcomes were complications (surgical site infection, readmission for infection, and wound-related return to operating room [OR]) within 90 days after surgery. chi(2) testing and Student t testing were used to assess differences between treatment groups while bivariate and multivariate regression was performed for outcome assessment.RESULTS:Two hundred sixty-four patients met criteria and were included. One hundred fifty-seven (59%) were treated with standard dressing and 107 (41%) with VAC. Patients treated with VAC were more likely to be older (P = .015), have diabetes (P = .041), have an elevated body mass index (P = .020), and had more levels of fusion (P = .002). Despite this, presence of VAC was independently associated with decreased 90-day infection (hazard ratio = 0.397, P = .023) and decreased 90-day return to OR for wound-related reasons (hazard ratio = 0.099, P = .031).CONCLUSION:Compared with the use of standard dressing, VAC was found to decrease surgical site infection and return to OR risk in trauma patients undergoing PSF.
C1 [Mehkri, Yusuf; Hernandez, Jairo; Panther, Eric; Pafford, Ryan; Rahmathulla, Gazanfar] Univ Florida, Dept Neurosurg, Coll Med, Jacksonville, FL 32209 USA.
   [Gendreau, Julian] Johns Hopkins Whiting Sch Engn, Dept Biomed Engn, Baltimore, MD USA.
   [Rao, Dinesh; Fiester, Peter] Univ Florida, Coll Med, Dept Neuroradiol, Jacksonville, FL 32209 USA.
   [Rahmathulla, Gazanfar] Univ Florida, Coll Med Jacksonville, Dept Neurosurg, 580W 8th St,Tower 1 8th Floor, Jacksonville, FL 32209 USA.
C3 State University System of Florida; University of Florida; Johns Hopkins
   University; State University System of Florida; University of Florida;
   State University System of Florida; University of Florida
RP Rahmathulla, G (通讯作者)，Univ Florida, Coll Med Jacksonville, Dept Neurosurg, 580W 8th St,Tower 1 8th Floor, Jacksonville, FL 32209 USA.
EM ymehkri@ufl.edu; hernandezjairo@ufl.edu; ericpanther@ufl.edu;
   jgendre1@jhu.edu; ryan.pafford@jax.ufl.edu; dinesh.rao@jax.ufl.edu;
   peter.fiester@jax.ufl.edu; gazanfar.rahmathulla@jax.ufl.edu
RI Rahmathulla FACS FCNS MBA, Gazanfar/D-1890-2014; Rahmathulla,
   Gazanfar/D-1890-2014
OI Rahmathulla FACS FCNS MBA, Gazanfar/0000-0002-0904-1840; Geneau,
   Julian/0000-0001-8412-0437; 
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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NR 28
TC 2
Z9 5
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2332-4252
EI 2332-4260
J9 OPER NEUROSURG
JI Oper. Neurosurg.
PD FEB
PY 2023
VL 24
IS 2
BP 138
EP 144
DI 10.1227/ons.0000000000000477
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 8C5ST
UT WOS:000917668800028
PM 36637298
DA 2026-07-24
ER
PT J
AU Meyer, J
   Roos, E
   Davies, RJ
   Buchs, NC
   Ris, F
   Toso, C
AF Meyer, Jeremy
   Roos, Elin
   Davies, Richard Justin
   Buchs, Nicolas Christian
   Ris, Frederic
   Toso, Christian
TI Does Prophylactic Negative-Pressure Wound Therapy Prevent Surgical Site
   Infection After Laparotomy? A Systematic Review and Meta-analysis of
   Randomized Controlled trials
SO WORLD JOURNAL OF SURGERY
LA English
DT Review
ID SURGERY; COMPLICATIONS; INCISIONS; IMPACT; COSTS
AB BackgroundProphylactic negative-pressure wound therapy (pNPWT) may prevent surgical site infection (SSI) after laparotomy, but existing meta-analyses pooling only high-quality evidence have failed to confirm this effect. Recently, several randomized controlled trials (RCTs) have been published. We performed an updated systematic review and meta-analysis to determine if pNPWT reduces the incidence of SSI after laparotomy.MethodsMEDLINE, Embase, CENTRAL and Web of Science were searched on the 25.08.2021 for RCTs reporting on the incidence of SSI in patients who underwent laparotomy with and without pNPWT. The systematic review was compliant with the AMSTAR2 recommendation and registered into PROSPERO. Risk ratios (RR) for SSI in patients with pNPWT, and risk difference (RD) between control and pNPWT patients, were obtained using random effects models. Heterogeneity was quantified using the I-2 value, and investigated using subgroup analyses, funnel plots and bubble plots. Risk of bias of included RCTs was assessed using the RoB2 tool.ResultsEleven RCTs were included, representing 973 patients who received pNPWT and 970 patients who received standard wound dressing. Pooled RR and RD between patients with and without pNPWT were of, respectively, 0.665 (95% CI 0.49-0.91, I-2: 38.7%, p = 0.0098) and -0.07 (95% CI -0.12 to -0.03, I-2: 53.6%, p = 0.0018), therefore demonstrating that pNPWT decreases the incidence of SSI after laparotomy. Investigation of source of heterogeneity identified a potential small-study effect.ConclusionThe protective effect of pNPWT against SSI after laparotomy is confirmed by high-quality pooled evidence.
C1 [Meyer, Jeremy; Buchs, Nicolas Christian; Ris, Frederic; Toso, Christian] Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Meyer, Jeremy; Buchs, Nicolas Christian; Ris, Frederic; Toso, Christian] Univ Geneva, Med Sch, Unit Surg Res, Geneva, Switzerland.
   [Meyer, Jeremy; Davies, Richard Justin] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Cambridge Colorectal Unit, Cambridge, England.
   [Roos, Elin] Karolinska Inst, Dept Global Publ Hlth, Solna, Sweden.
C3 University of Geneva; University of Geneva; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of
   Cambridge; Karolinska Institutet
RP Meyer, J (通讯作者)，Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.; Meyer, J (通讯作者)，Univ Geneva, Med Sch, Unit Surg Res, Geneva, Switzerland.; Meyer, J (通讯作者)，Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Cambridge Colorectal Unit, Cambridge, England.
EM jeremy.meyer@hcuge.ch
RI Meyer, Jeremy/AAP-3367-2020; Ris, Frederic/H-7030-2019; Toso,
   Christian/E-7785-2018
OI Meyer, Jeremy/0000-0003-3381-9146; Ris, Frederic/0000-0001-7421-6101;
   Toso, Christian/0000-0003-1652-4522
FU University of Geneva
FX Open access funding provided by University of Geneva.
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NR 35
TC 18
Z9 19
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD JUN
PY 2023
VL 47
IS 6
BP 1464
EP 1474
DI 10.1007/s00268-023-06908-7
EA JAN 2023
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AK5X9
UT WOS:000918726600001
PM 36658232
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Lenet, T
   Gilbert, RWD
   Abou-Khalil, J
   Balaa, FK
   Martel, G
   Brind'Amour, A
   Bertens, KA
AF Lenet, Tori
   Gilbert, Richard W. D.
   Abou-Khalil, Jad
   Balaa, Fady K.
   Martel, Guillaume
   Brind'Amour, Alexandre
   Bertens, Kimberly A.
TI The impact of prophylactic negative pressure wound therapy on surgical
   site infections in pancreatic resection: A systematic review and
   meta-analysis
SO HPB
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; HIGH-RISK; COMPLICATIONS; HEAD
AB Background: Surgical site infections (SSI) cause significant morbidity. Prophylactic negative pressure wound therapy (NPWT) may promote wound healing and decrease SSI. The objective is to evaluate the effect of prophylactic NPWT on SSI in patients undergoing pancreatectomy.
   Methods: Electronic databases were searched from inception until April 2022. Randomized controlled trials (RCTs) comparing prophylactic NPWT to standard dressings in patients undergoing pancreatectomy were included. The primary outcome was the risk of SSI. Secondary outcomes included the risk of superficial and deep SSI and organ space infection (OSI). Random effects models were used for meta-analysis.
   Results: Four single-centre RCTs including 309 patients were identified. Three studies were industry-sponsored, and two were at high risk of bias. There was no significant difference in the risk of SSI in patients receiving NPWT vs. control (14% vs. 21%, RR = 0.72, 95%CI = 0.32- 1.60, p = 0.42, I-2 = 53%). Likewise, there was no significant difference in the risk of superficial and deep SSI or OSI. No significant difference was found on subgroup analysis of patients at high risk of wound infection or on sensitivity analysis of studies at low risk of bias.
   Conclusion: Prophylactic NPWT does not significantly decrease the risk of SSI among patients undergoing pancreatectomy. Insufficient evidence exists to justify the routine use of NPWT.
C1 [Lenet, Tori; Gilbert, Richard W. D.; Abou-Khalil, Jad; Balaa, Fady K.; Martel, Guillaume; Bertens, Kimberly A.] Univ Ottawa, Ottawa Hosp, Dept Surg, Liver & Pancreas Surg Unit, Ottawa, ON, Canada.
   [Lenet, Tori; Martel, Guillaume; Bertens, Kimberly A.] Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
   [Brind'Amour, Alexandre] Univ Laval, Dept Surg, CHU Quebec, Quebec City, PQ, Canada.
C3 University of Ottawa; Ottawa Hospital Research Institute; University of
   Ottawa; Ottawa Hospital Research Institute; Laval University; Laval
   University Hospital
RP Bertens, KA (通讯作者)，Univ Ottawa, Ottawa Hosp, Dept Surg, Liver & Pancreas Surg Unit, Ottawa, ON, Canada.; Bertens, KA (通讯作者)，Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
EM kbertens@toh.ca
RI Brind'Amour, Alexandre/AAA-7957-2021; Martel, Guillaume/H-7356-2019
OI Brind'Amour, Alexandre/0000-0002-9607-6987; Gilbert,
   Richard/0000-0002-3319-0432; Lenet, Tori/0000-0002-6797-1931; 
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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NR 34
TC 7
Z9 7
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1365-182X
EI 1477-2574
J9 HPB
JI HPB
PD DEC
PY 2022
VL 24
IS 12
BP 2035
EP 2044
DI 10.1016/j.hpb.2022.08.010
EA DEC 2022
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 8F3VH
UT WOS:000919594000001
PM 36244906
DA 2026-07-24
ER
PT J
AU McMillan, H
   Vo, UG
   Moss, JL
   Barry, IP
   Bosanquet, DC
   Richards, T
AF McMillan, Hayley
   Vo, Uyen G.
   Moss, Jana-Lee
   Barry, Ian P.
   Bosanquet, David C.
   Richards, Toby
TI Controlling the controls: what is negative pressure wound therapy
   compared to in clinical trials?
SO COLORECTAL DISEASE
LA English
DT Article
DE control dressing; negative pressure wound therapy; standard of care;
   surgical site infection
ID SURGICAL SITE INFECTION; CESAREAN DELIVERY; PRIMARY HIP; COMPLICATIONS;
   RISK; DRESSINGS; SURGERY; ARTHROPLASTY; METAANALYSIS; LAPAROTOMY
AB AimSurgical site infections (SSIs) are common following colorectal operations. Clinical trials suggest that closed incision negative pressure wound therapy (ciNPWT) may reduce SSIs compared to a 'standard of care' group. However, wound management in the standard of care group may vary. The aim of this review was to assess the control arms in trials of ciNPWT for potential confounding variables that could influence the rates of SSI and therefore the trial outcomes. MethodsA mapping review of the PubMed database was undertaken in the English language for randomized controlled trials that assessed, in closed surgical wounds, the use of ciNPWT compared to standard of care with SSI as an outcome. Data regarding wound care to assess potential confounding factors that may influence SSI rates were compared between the ciNPWT and standard of care groups. Included were the method of wound closure, control dressing type, frequency of dressing changes and postoperative wound care (washing). ResultsTwenty-seven trials were included in the mapping review. There was heterogeneity in ciNPWT duration. There was little control in the comparator standard of care groups with a variety of wound closure techniques and different control dressings used. Overall standard of care dressings were changed more frequently than the ciNPWT dressing and there was no control over wound care or washing. No standard for 'standard of care' was apparent. ConclusionIn randomized trials assessing the intervention of ciNPWT compared to standard of care there was considerable heterogeneity in the comparator groups and no standard of care was apparent. Heterogeneity in dressing protocols for standard of care groups could introduce potential confounders impacting SSI rates. There is a need to standardize care in ciNPWT trials to assess potential meaningful differences in SSI prevention.
C1 [McMillan, Hayley; Vo, Uyen G.; Moss, Jana-Lee; Richards, Toby] Univ Western Australia, Fiona Stanley Hosp, Div Surg, Perkins South Bldg, Perth, WA, Australia.
   [Vo, Uyen G.; Moss, Jana-Lee; Barry, Ian P.] Fiona Stanley Hosp, Dept Vasc Surg, Perth, WA, Australia.
   [Bosanquet, David C.] Royal Gwent Hosp, South East Wales Vasc Network, Newport, Gwent, Wales.
C3 South Metropolitan Health Service; Fiona Stanley Fremantle Hospitals
   Group; Fiona Stanley Hospital; University of Western Australia; South
   Metropolitan Health Service; Fiona Stanley Fremantle Hospitals Group;
   Fiona Stanley Hospital; Royal Gwent Hospital
RP McMillan, H (通讯作者)，Univ Western Australia, Fiona Stanley Hosp, Div Surg, Perkins South Bldg, Perth, WA, Australia.
EM hayley.mcmillan@health.wa.gov.au
RI Richards, Toby/K-6547-2013; Bosanquet, David/AAB-1557-2022
OI Richards, Toby/0000-0001-9872-4653; Vo, Uyen Giao/0000-0002-6340-9263;
   McMillan, Hayley/0000-0003-2599-0699; Bosanquet,
   David/0000-0003-2304-0489
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NR 53
TC 0
Z9 0
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD APR
PY 2023
VL 25
IS 4
BP 794
EP 805
DI 10.1111/codi.16465
EA JAN 2023
PG 12
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA F1OX8
UT WOS:000919738900001
PM 36579358
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Gläsel, S
   Jarvers, JS
   Pieroh, P
   Heyde, CE
   Spiegl, UJ
AF Glaesel, Stefan
   Jarvers, Jan-Sven
   Pieroh, Philipp
   Heyde, Christoph-Eckhard
   Spiegl, Ulrich J.
TI Does the use of epicutaneous vacuum-assisted closure after revision
   surgery on the spine reduce further wound revision surgery?
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
DE Epicutaneous vacuum therapy; Surgical site infection; Wound revision
   surgery
ID PRESSURE; THERAPY; INFECTION; DEHISCENCE; FUSION
AB PurposeThis study aimed to investigate the effect of epicutaneous vacuum therapy on the rate of unplanned spinal wound revisions compared with conventional wound dressing.MethodsThis retrospective study included patients who underwent unplanned revision spine surgery after primary aseptic spine surgery who were treated at a level I spine centre between December 2011 and December 2019. Patients with revision surgery who required a further unplanned revision surgery during the inpatient stay were considered a treatment failure. The epicutaneous vacuum-assisted closure (Epi-VAC) therapy was the standard treatment method beginning in 2017 (the epi-VAC group). Before, conventional wound dressing was used (the control group (CG)). In addition, a one-to-one matched-pair comparison analysis was performed between both groups.ResultsOf 218 patients, 48 were in the epi-VAC group. The mean age was 65.1 years (epi-VAC 68.2 to CG 64.3 years (P = 0.085)), and the mean body mass index (BMI) was 28.2 kg/m(2) (epi-VAC 29.4 to CG 27.9 kg/m(2) (P = 0.16)). No significant differences in the treatment failure rate could be detected between the two groups (epi-VAC 25% to CG 22.4% (P = 0.7)). There was also no significant difference for the matched-pair analysis (epi-VAC 26.1% to CG 15.2% (P = 0.3)). An elevated CRP level (C-reactive protein) immediately before the first wound revision was a significant risk factor for further revision surgery (treatment failure: 135.2 +/- 128.6; no treatment failure: 79.7 +/- 86.1 mg/l (P < 0.05)).ConclusionConcerning repeat unplanned wound revision after spinal revision surgery, we cannot demonstrate an advantage of the epicutaneous vacuum therapy over conventional wound dressing.
C1 [Glaesel, Stefan] Sana Klinikum Borna, Dept Spine Surg & Neurotraumatol, Borna, Germany.
   [Jarvers, Jan-Sven; Pieroh, Philipp; Heyde, Christoph-Eckhard; Spiegl, Ulrich J.] Univ Leipzig, Dept Orthopaed Trauma Surg & Plast Surg, Liebigstr 20, D-04103 Leipzig, Germany.
C3 Leipzig University
RP Spiegl, UJ (通讯作者)，Univ Leipzig, Dept Orthopaed Trauma Surg & Plast Surg, Liebigstr 20, D-04103 Leipzig, Germany.
EM uli.spiegl@gmx.de
RI ; Heyde, Christoph - E./AAV-9440-2021
OI Spiegl, Ulrich/0000-0002-5179-4192; 
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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   [Anonymous], TERM INCISIONAL
   [Anonymous], FILESREFERENZDATENOP
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NR 21
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD MAR
PY 2023
VL 47
IS 3
BP 803
EP 811
DI 10.1007/s00264-023-05695-z
EA JAN 2023
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 9B4XQ
UT WOS:000920196500001
PM 36648534
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Chang, SS
   Zhang, F
   Chen, W
   Zhou, J
   Nie, KY
   Deng, CL
   Wei, ZR
AF Chang, Shusen
   Zhang, Fang
   Chen, Wei
   Zhou, Jian
   Nie, Kaiyu
   Deng, Chengliang
   Wei, Zairong
TI Outcomes of integrated surgical wound treatment mode based on tibial
   transverse transport for diabetic foot wound
SO FRONTIERS IN SURGERY
LA English
DT Article
DE integrated surgical wound treatment; diabetic foot ulcer; tibial
   transverse transport; antibiotic bone cement; vacuum sealing drainage
ID CLASSIFICATION; AMPUTATION; INFECTION; ULCER
AB BackgroundDiabetic foot ulcer (DFU) is frequently difficult to heal and finally leads to amputation, resulting in high mortality rate in diabetic patients. To date, effective and optimal therapies are still lacking. This study aims to investigate the efficacy of integrated surgical wound treatment (ISWT) mode on diabetic foot wound. MethodsFrom January 2021 to December 2021, 13 diabetic foot patients with Wagner grade 3 to 4 were treated with ISWT mode, which combined TTT technique with debridement, induced membrane technique, vacuum sealing drainage (VSD) technique and skin grafting technique. The time of wound healing, the skin temperature at midpoint of dorsum of affected foot (T), visual analogue scale (VAS) score and ankle-brachial index (ABI) was measured before and after surgery. CTA examination of the lower extremity arteries was performed at the end of the cortex transport to evaluate the small arteriolar formation of the lower extremity. The complications occurred in each patient were recorded. Results13 patients with age ranging from 45 to 66 years were followed up for 3 to 13 months. All patients healed completely without amputation being performed, no serious complications were found except for one case of nail channel infection. The mean healing time was 25.8 +/- 7.8 days, with a range of 17 to 39 days. The mean time of carrying external fixation scaffolds and resuming walking was 71.8 +/- 10.0 and 30.8 +/- 9.1 days, with a range of 56 to 91 days and 18 to 45 days, respectively. The skin temperature at midpoint of dorsum of affected foot (T), VAS and ABI was all improved significantly at 3 months after surgery. Furthermore, CTA examination showed an increase in the number of lower extremity arteries and a thickening in the size of small arteriolar compared with those of pre-operative, and the collateral circulation of lower extremity was established and interweaved into a network. ConclusionIntegrated surgical treatment of diabetic foot wound can achieve satisfactory clinical results.
C1 [Chang, Shusen; Zhang, Fang; Chen, Wei; Zhou, Jian; Nie, Kaiyu; Deng, Chengliang; Wei, Zairong] Zunyi Med Univ, Dept Burn & Plast Surg, Affiliated Hosp, Zunyi, Peoples R China.
   [Chang, Shusen; Zhang, Fang; Chen, Wei; Zhou, Jian; Nie, Kaiyu; Deng, Chengliang; Wei, Zairong] Zunyi Med Univ, Collaborat Innovat Ctr Tissue Damage Repair & Rege, Zunyi, Peoples R China.
C3 Zunyi Medical University; Zunyi Medical University
RP Wei, ZR (通讯作者)，Zunyi Med Univ, Dept Burn & Plast Surg, Affiliated Hosp, Zunyi, Peoples R China.; Wei, ZR (通讯作者)，Zunyi Med Univ, Collaborat Innovat Ctr Tissue Damage Repair & Rege, Zunyi, Peoples R China.
EM zairongwei@163.com
RI Chang, Shusen/KRQ-3101-2024
FU Guizhou province, PR China [2020-5012, 2020-39, 2021-3]; Ministry
   Jointly Built Collaborative Innovation Center Project [2020-39, 2021-3]
FX This work was supported by the Wound Surgery Integrated Treatment
   Science and Technology Innovation Talent Team (2020-5012) of Guizhou
   province, PR China; Provincial and Ministry Jointly Built Collaborative
   Innovation Center Project (2020-39) of Guizhou province, PR China;
   Construction of Innovative Talent Platform Carrier for Precise Wound
   Repair (2021-3) of Guizhou province, PR China.
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NR 28
TC 11
Z9 20
U1 3
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JAN 16
PY 2023
VL 9
AR 1051366
DI 10.3389/fsurg.2022.1051366
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8I3YC
UT WOS:000921659400001
PM 36726959
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wu, YZ
   Huang, CH
   Zhang, XY
   Shen, GL
AF Wu, Yi-Zhu
   Huang, Chun-Hui
   Zhang, Xin-Yu
   Shen, Guo-Liang
TI The clinical application effects of artificial dermis scaffold and
   autologous split-thickness skin composite grafts combined with
   vacuum-assisted closure in refractory wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE artificial dermis scaffold; autologous split-thickness skin graft;
   refractory wounds; vacuum-assisted closure; wound healing
ID THERAPY
AB To investigate the clinical application effects of artificial dermis scaffold and autologous split-thickness skin composite grafts combined with vacuum-assisted closure (V.A.C) in refractory wounds. A retrospective analysis was performed on 70 patients with refractory wounds admitted to the First Affiliated Hospital of Soochow University from June 2019 to December 2021 (44 males and 25 females, with an average age of 49.3 +/- 21.4 years). There were 26 patients with chronic ulcers; 3 patients with cancerous wounds; 16 patients with hot crush injuries; and 25 patients with traumatic wounds, including 21 cases of hands, 33 cases of feet, 6 cases of upper limbs, and 10 cases of lower limbs. The patients were divided into an artificial dermis scaffold group (35 patients, including 21 males and 14 females, aged 49.5 +/- 21.3 years) and a skin graft group (35 patients, including 23 males and 11 females, aged 49.1 +/- 21.5 years). In the artificial dermis scaffold group, after debridement, the artificial dermis scaffold was transplanted for approximately 2 weeks until the wound surface was well vascularized, after which the autologous split-thick skin graft was transplanted. Negative pressure wound therapy was performed throughout the treatment. In the skin grafting group, after debridement, the autologous split-thickness skin graft (aSTSG) was transplanted, and negative pressure wound therapy was performed continuously. The wound healing rate; skin graft survival rate; postoperative wound infection; exudative fluid volume; subcutaneous haematoma; hospitalisation time; hospitalisation cost; Vancouver Scar Scale (VSS) score, used to evaluate the scar of the recipient area at 6 months after the operation; and the sensory disorder grading method, used to evaluate the sensory recovery of the recipient area, were compared between the two groups. All 70 refractory wounds healed. In the artificial dermis scaffold group, the skin graft survival rate was 90% (86%-95%), the hospitalisation time was 38 (29-45) days, the hospitalisation cost was 148 102 (118242-192327) yuan, and the VSS score was 1.9 +/- 1.3. There were significant differences in skin graft survival rate (70% [60%-80%]), length of hospital stay (21 [14-28] days), hospitalisation cost (76 201 [39228-135 919] yuan) and VSS score [6.1 +/- 3.6] between the skin graft group and the artificial dermis scaffold group (P < .05). The skin graft survival rate, scar hyperplasia and sensory recovery of the recipient area in the artificial dermis scaffold group were better than those in the skin graft group, but the hospitalisation time was relatively longer, and the hospitalisation cost was relatively higher. Wound healing rate, postoperative wound infection, exudate volume, and subcutaneous haematoma of patients in the two groups were similar, and there were no significant differences (P > .05). The artificial dermis scaffold and composite transplantation of autologous aSTSG with V.A.C can promote painless wound healing and improve the skin survival rate, skin colour and lustre, and flexible smooth texture and is conducive to less scar hyperplasia and postoperative functional exercise and recovery. This method provides a reasonable and effective scheme for the treatment of clinical refractory wounds.
C1 [Wu, Yi-Zhu; Huang, Chun-Hui; Zhang, Xin-Yu; Shen, Guo-Liang] Soochow Univ, Affiliated Hosp 1, Dept Burn & Plast Surg, Suzhou, Peoples R China.
   [Shen, Guo-Liang] Soochow Univ, Affiliated Hosp 1, Dept Burn & Plast Surg, 188 Shizi St, Suzhou 215000, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Shen, GL (通讯作者)，Soochow Univ, Affiliated Hosp 1, Dept Burn & Plast Surg, 188 Shizi St, Suzhou 215000, Peoples R China.
EM sdfyysgl@163.com
RI ; huang, chunhui/HJA-1599-2022
OI Wu, Yizhu/0000-0002-4066-1204; 
FU National Natural Science Foundation of China [31370968]
FX National Natural Science Foundation of China, Grant/Award Number:
   31370968
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NR 15
TC 15
Z9 18
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2023
VL 20
IS 6
BP 2113
EP 2120
DI 10.1111/iwj.14086
EA FEB 2023
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA L4AN9
UT WOS:000924050700001
PM 36726042
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhu, JJ
   Sun, Q
   Xu, WL
   Geng, J
   Feng, Q
   Zhao, ZG
   Li, S
AF Zhu, Junjia
   Sun, Qi
   Xu, Wenlong
   Geng, Jun
   Feng, Qiang
   Zhao, Zhenguo
   Li, Sen
TI Effect of Negative Pressure Wound Therapy on Surgical Site Infections
   following Stoma Reversal in Colorectal Surgery: A Meta-Analysis
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Review
DE Colorectal surgery; stoma reversal; surgical site infection;
   negative-pressure wound therapy; NPWT
ID VACUUM-ASSISTED CLOSURE; PURSESTRING CLOSURE; OSTOMY CLOSURE; ILEOSTOMY;
   PREVENTION; OUTCOMES; RISK; MULTICENTER; MANAGEMENT; GUIDELINE
AB BackgroundSurgical site infections (SSI) are common complications after surgery, which cause other complications and increase medical costs. However, the effect of negative-pressure wound therapy (NPWT) for the prevention of SSI at stoma reversal remains inconclusive, with controversial results. This meta-analysis aimed to evaluate the safety and efficacy of NPWT following stoma reversal in colorectal surgery to prevent SSI and other wound complications.MethodsWe conducted a systematic search of the PubMed, EMBASE, and Cochrane Library databases for articles published up to July 2022 and identified relevant studies reporting the NPWT administration following stoma reversal in colorectal surgery compared with non-pressure dressing. The primary outcome was the incidence of SSI, and the secondary outcomes were hematoma, seroma, and length of hospital stay (LOS).ResultsNine studies were included in the meta-analysis, with 825 patients with (n = 310) or without (n = 515) NPWT. Pooled SSI rate was lower in the NPWT group than in the non-pressure dressing group (OR = 0.50; 95% CI: 0.29, 0.84; P = 0.01). There was no significant effect on hematoma (OR = 0.21; 95% CI: 0.03, 1.27; P = 0.09), seroma (OR = 0.26; 95% CI: 0.05, 1.28; P = 0.1) and LOS (MD = -0.16, 95% CI: -0.83, 0.51; P = 0.64).ConclusionThe use of NPWT following stoma reversal in colorectal surgery reduced the incidence of SSI. However, this conclusion needs to be interpreted with caution, and further studies should be conducted to confirm in higher-quality RCTs.
C1 [Zhu, Junjia; Sun, Qi; Xu, Wenlong; Feng, Qiang; Zhao, Zhenguo; Li, Sen] Nantong Univ, Jiangyin Peoples Hosp, Dept Gen Surg, Jiangyin, Peoples R China.
   [Geng, Jun] Nantong Univ, Jiangyin Peoples Hosp, Dept Anesthesiol, Jiangyin, Peoples R China.
   [Zhao, Zhenguo; Li, Sen] Nantong Univ, Jiangyin Peoples Hosp, Dept Gen Surg, 3 Yingrui Rd, Nantong 214400, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Zhao, ZG; Li, S (通讯作者)，Nantong Univ, Jiangyin Peoples Hosp, Dept Gen Surg, 3 Yingrui Rd, Nantong 214400, Jiangsu, Peoples R China.
EM 54yonggan@163.com; jyrmyyls@163.com
OI Zhao, Zhenguo/0000-0003-1230-3116
FU Youth Research Project Fund of Wuxi Municipal Health Commission; Wuxi
   Taihu Lake talent plan' medical and health high level talent project
   [NO2020103]; Wuxi precision medicine project [J202009]
FX This study was supported by Youth Research Project Fund of Wuxi
   Municipal Health Commission (NO.Q201949); Wuxi Taihu Lake talent plan'
   medical and health high level talent project, NO2020103; Wuxi precision
   medicine project, J202009.
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NR 46
TC 9
Z9 10
U1 1
U2 12
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0894-1939
EI 1521-0553
J9 J INVEST SURG
JI J. Invest. Surg.
PD DEC 31
PY 2023
VL 36
IS 1
DI 10.1080/08941939.2023.2175079
EA JAN 2023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA N3O1M
UT WOS:000924672700001
PM 36740239
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhang, RL
   Zhang, YH
   Hou, LY
   Yan, CY
AF Zhang, Rongli
   Zhang, Yahui
   Hou, Liyuan
   Yan, Chengyong
TI Vacuum-assisted closure versus conventional dressing in necrotizing
   fasciitis: a systematic review and meta-analysis
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Review
DE Necrotizing fasciitis; Vacuum-assisted closure; Conventional dressing;
   Meta-analysis
ID PRESSURE WOUND THERAPY; FOURNIERS GANGRENE; INSTILLATION; MANAGEMENT;
   NECK; HEAD
AB BackgroundNecrotizing fasciitis is a rapid and severe soft tissue infection that targets subcutaneous fat tissue, muscle, and fascia. This study compares the clinical outcomes of vacuum-assisted closure (VAC) versus conventional dressing on necrotizing fasciitis.MethodsWe systematically searched Embase, Cochrane, and PubMed for clinical trials (published between January 1, 1995 and September 30, 2021), which compared VAC with conventional dressing for necrotizing fasciitis. The mortality rate of necrotizing fasciitis was the primary outcome of this study. The number of debridements, the total length of hospital stay, and the complication rate were secondary outcomes. A random effects model assessed all pooled data.ResultsA total of 230 identified studies and seven controlled clinical trials met the inclusion criteria and were included in this analysis (n = 249 participants). Compared to the conventional dressing, patients treated with VAC had a significantly lower mortality rate [OR = 0.27, 95% CI (0.09, 0.87)] (P = 0.03). Total length of hospital stays [MD = 8.46, 95% CI (- 0.53, 17.45)] (P = 0.07), number of debridements [MD = 0.86, 95% CI (- 0.58, 2.30)] (P = 0.24), and complication rate [OR = 0.64, 95% CI (0.07, 5.94)] (P = 0.69) were not significant. These results did not show significant differences between both groups treated with VAC or conventional treatment.ConclusionVAC could significantly decrease the death rate compared to conventional dressing. No significant impacts were found on the number of debridements, the total length of hospital stay, and the complication rate in this study.Level of evidence Level-III.Registration Research Registry (reviewregistry1246).
C1 [Zhang, Rongli; Zhang, Yahui; Hou, Liyuan; Yan, Chengyong] Hebei Med Univ, Dept Orthopaed Surg, Hosp 3, Shijiazhuang, Peoples R China.
C3 Hebei Medical University
RP Yan, CY (通讯作者)，Hebei Med Univ, Dept Orthopaed Surg, Hosp 3, Shijiazhuang, Peoples R China.
EM drcyyan@126.com
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NR 34
TC 23
Z9 31
U1 1
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD FEB 4
PY 2023
VL 18
IS 1
AR 85
DI 10.1186/s13018-023-03561-7
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 8O6KH
UT WOS:000925943300003
PM 36737764
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lambrechts, MJ
   D'Antonio, ND
   Issa, TZ
   Levy, HA
   Yalla, GR
   Berthiaume, E
   Ciesielka, KA
   Kepler, CK
   Canseco, JA
AF Lambrechts, Mark J.
   D'Antonio, Nicholas D.
   Issa, Tariq Z.
   Levy, Hannah A.
   Yalla, Goutham R.
   Berthiaume, Emily
   Ciesielka, Kerri-Anne
   Kepler, Christopher K.
   Canseco, Jose A.
TI The Usefulness of Closed Incision Negative Pressure Wound Therapy After
   Spinal Fusion: A Systematic Review and Meta-Analysis
SO WORLD NEUROSURGERY
LA English
DT Review
DE Key words-Complications; Meta-analysis; Negative-pressure wound therapy;
   Spine; Surgical site infection; Systematic review; Wound vacuum
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; RISK-FACTORS; SURGERY;
   EXPRESSION; HIP
AB - OBJECTIVE: To determine if closed incision negative pressure wound therapy (ciNPWT) decreases surgical site infection (SSI) or wound dehiscence after spinal fusion. - METHODS: Following PRISMA guidelines, a systematic review and metaanalysis were conducted to identify studies using ciNPWT after spinal fusion. Funnel plots and quality scores of the articles were performed to determine if the articles were at risk of bias. Forest plots were conducted to identify the treatment effect of ciNPWT after spinal fusion. - RESULTS: A total of 8 studies comprising 1061 patients who received ciNPWT or a standard postoperative dressing after spinal fusion were included. The rate of SSI (ciNPWT, 4.49% [95% confidence interval (CI), 2.48-8.00] vs. control, 11.32% [95% CI, 7.51-16.70]; P = 0.0103) was significantly lower for patients treated with ciNPWT. A fixed-effects model showed no significant difference between patients who received ciNWPT or a standard postoperative dressing with respect to requiring reoperations for wound debridement (odds ratio, 1.25; 95% CI, 0.64-2.41). In addition, wound dehiscence was not significantly different between the 2 groups, although it was nonsignificantly lower in ciNWPT-treated patients (ciNPWT, 4.59% [95% CI, 2.49-8.31] vs. control: 7.48% [95% CI, 4.38-12.47]; P = 0.23). - CONCLUSIONS: ciNPWT may reduce the rates of SSI after spinal fusion. The use of ciNWPT may also significantly reduce the burden associated with postoperative wound complications, but the meta-analysis was insufficiently powered to make this association. Additional studies may identify a subset of patients who benefit from ciNPWT for other wound-related complications.
C1 [Lambrechts, Mark J.; D'Antonio, Nicholas D.; Issa, Tariq Z.; Levy, Hannah A.; Yalla, Goutham R.; Berthiaume, Emily; Ciesielka, Kerri-Anne; Kepler, Christopher K.; Canseco, Jose A.] Thomas Jefferson Univ, Rothman Inst, Dept Orthopaed Surg, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University; Rothman Institute
RP Lambrechts, MJ (通讯作者)，Thomas Jefferson Univ, Rothman Inst, Dept Orthopaed Surg, Philadelphia, PA 19107 USA.
EM mark.lambrechts@rothmanortho.com
RI Canseco, Jose/AAT-1667-2020; lambrechts, mark/ABG-2062-2021
OI lambrechts, mark/0000-0002-9106-2228; Yalla,
   Goutham/0000-0003-0863-2953; Issa, Tariq/0000-0002-0978-5225
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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   Wang C, 2019, J ORTHOP SURG RES, V14, DOI 10.1186/s13018-019-1488-z
   Wells GA, 2014, NEWCASTLE OTTAWA SCA
   Xie WW, 2022, INT WOUND J, V19, P1319, DOI 10.1111/iwj.13726
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NR 43
TC 13
Z9 13
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD DEC
PY 2022
VL 168
BP 258
EP +
DI 10.1016/J.WNEU.2022.09.048
PG 11
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 8P3BU
UT WOS:000926401400003
PM 36116727
DA 2026-07-24
ER
PT J
AU Li, X
   Ding, W
   Wang, J
AF Li, Xin
   Ding, Wei
   Wang, Jun
TI Negative pressure sealing drainage with antibiotic bone cement for the
   treatment of skin and soft tissue defects in the older population with
   bone exposure
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE antibiotic; bone cement; bone exposure; drainage; older; soft tissue
   trauma defect; vacuum sealing drainage; wound; wound care; wound
   dressing; wound healing
AB Objective: To observe the clinical efficacy of vacuum sealing drainage (VSD) combined with antibiotic bone cement in the treatment of skin and soft tissue defects of the extremities with bone exposure in the older population.
   Method: From January 2016 to December 2018, VSD combined with antibiotic bone cement was used to treat 12 older patients with skin and soft tissue defects of the extremities and bone exposure. The study cohort consisted of eight male patients and four female patients aged between 60-95 years, with a median of 75 years. The injury sites included four cases of hand, one case of calf, one case of ankle and six cases of back of foot. The area of skin and soft tissue defects ranged from 2.7x4.1cm to 4.8x4.9cm. There were four infected wounds and eight contaminated wounds. The time from injury to operation was 1.5-6 hours, with a median of 5 hours. In the first stage of the treatment, the wound was covered with a VSD dressing; in the second stage the VSD dressing was replaced with antibiotic bone cement after infection control; and in the third stage, the bone cement was removed and the wound was transplanted with medium-thickness skin grafts according to the wound condition. The skin graft survival and wound healing were assessed.
   Results: After the first-stage debridement, three of the 12 patients had wound infections, including two cases of meticillin-resistant Staphylococcus aureus infection and one case of Pseudomonas aeruginosa infection. After the bone cement was removed in the third stage, five of the 12 patients underwent free medium-thickness skin grafting on the wound surface (the area of the autologous skin ranged from 2.9x4.3cm to 4.9x5.0cm), and seven patients continued to change dressing routinely. All patients were followed up for 4-15 months, with a median of 10 months. All skin grafts survived and the wounds healed. The healing time was 48-115 days, with a median of 72 days. At the last follow-up, the skin of the affected limb was slightly darker than the surrounding skin, and the appearance was smooth, without obvious scar tissue formation.
   Conclusion: VSD combined with antibiotic bone cement in the treatment of skin and soft tissue defects of the extremities with bone exposure in the older population has a high survival rate of skin grafts and good wound healing. It is worthy of clinical application.
C1 [Li, Xin; Ding, Wei; Wang, Jun] Wenzhou Med Univ, Peoples Hosp Xiaoshan Dist 1, Xiaoshan Affiliated Hosp, Hangzhou, Zhejiang, Peoples R China.
C3 Wenzhou Medical University
RP Wang, J (通讯作者)，Wenzhou Med Univ, Peoples Hosp Xiaoshan Dist 1, Xiaoshan Affiliated Hosp, Hangzhou, Zhejiang, Peoples R China.
EM 323372702@qq.com
CR Al Thaher Y, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0207753
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   World Health Organization, PREV CARD DIS GUID A
NR 16
TC 3
Z9 4
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2023
VL 32
IS 2
BP 104
EP 108
DI 10.12968/jowc.2023.32.2.104
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 8Q4HN
UT WOS:000927170100007
PM 36735529
DA 2026-07-24
ER
PT J
AU Lim, S
   Lee, DY
   Kim, B
   Yoon, JS
   Han, YS
   Eo, S
AF Lim, SooA
   Lee, Dong Yun
   Kim, BumSik
   Yoon, Jung Soo
   Han, Yea Sik
   Eo, SuRak
TI Devastating complication of negative pressure wound therapy after deep
   inferior epigastric perforator free flap surgery: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Negative Pressure Wound Therapy; Complications; Breast reconstruction;
   Deep inferior epigastric artery perforator; Free flap; Burn injury; Case
   report
ID VACUUM-ASSISTED CLOSURE; BURN; MANAGEMENT; SAFETY
AB BACKGROUND
   Thermal injuries on free transferred or replanted tissues resulting from loss of sensibility are an infrequent occurrence. They require immediate and appropriate management before they progress to an irreversible condition. Although negative pressure wound therapy (NPWT) can prevent wound progression by increasing microcirculation, the inappropriate application of NPWT on complication-threatened transferred and replanted tissues can induce an adverse effect. CASE SUMMARY
   A 48-year-old woman who underwent immediate breast reconstruction with a deep inferior epigastric artery perforator free flap. While applying a heating pad directly to the flap site, she sustained a deep second to third-degree contact burn over 30% of the transferred flap on postoperative 7 d. As the necrotic changes had progressed, we applied an NPWT dressing over the burned area after en-bloc debridement of the transferred tissues on postoperative 21 d. After 4 d of NPWT application, the exposed fatty tissues of the flap changed to dry and brown-colored necrotic tissues. Upon further debridement, we noted that the wound gradually reached total necrosis with a collapsed vascular pedicle of deep inferior epigastric artery. CONCLUSION
   Although NPWT has been shown to be successful for treating various wound types, the significant risk of NPWT application in short-lasting reconstructed flap wounds after thermal injury should be reminded.
C1 [Lim, SooA; Lee, Dong Yun; Kim, BumSik; Yoon, Jung Soo; Han, Yea Sik; Eo, SuRak] DongGuk Univ, Med Ctr, Dept Plast & Reconstruct Surg, Dongguk Ro 77, Goyang 10326, South Korea.
C3 Dongguk University
RP Eo, S (通讯作者)，DongGuk Univ, Med Ctr, Dept Plast & Reconstruct Surg, Dongguk Ro 77, Goyang 10326, South Korea.
EM sreodoc@gmail.com
RI ; Lee, Dong Yun/QPA-1583-2026; Eo, SuRak/JXM-4124-2024
OI Lee, Dong Yun/0000-0002-5323-6469; Yoon, Jung Soo/0000-0003-2462-5702
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bi HD, 2018, J RECONSTR MICROSURG, V34, P200, DOI 10.1055/s-0037-1608621
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   Payne Caroline, 2014, Eplasty, V14, pe20
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NR 23
TC 1
Z9 2
U1 0
U2 2
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD JAN 6
PY 2023
VL 11
IS 1
BP 143
EP 149
DI 10.12998/wjcc.v11.i1.143
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8R7LD
UT WOS:000928071200015
PM 36687191
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU van Kessel, CS
   Mendes, C
   Young, CJ
AF van Kessel, Charlotte S.
   Mendes, Colleen
   Young, Christopher J.
TI Peristomal Necrosis Following Cytoreductive Surgery and Hyperthermic
   Intraperitoneal Chemotherapy: A Case Report
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Abcarian stoma; Colostomy; Ileostomy; Multidisciplinary approach; NPWT
   therapy; Peristomal necrosis; Stoma; Wound debridement
ID VACUUM-ASSISTED CLOSURE; STOMA; COMPLICATIONS; ILEOSTOMY; MORBIDITY;
   LIFE
AB BACKGROUND: Peristomal necrosis is a rare but challenging condition requiring multidisciplinary management involving surgical debridement and intensive WOC nurse management.
   CASE: Mr T was a 56-year-old man who underwent cytoreductive surgery with intraperitoneal chemotherapy for a high-grade appendiceal neoplasm. As part of the procedure, an Abcarian stoma (end-ileostomy with a distal lumen from the transverse colon brought out flush with skin beside the proximal stoma) was created. Postoperatively there was leakage of effluent under the subcutaneous skin resulting in full-thickness necrosis of the peristomal area requiring surgical debridement. Consequently, a large peristomal skin defect occurred, resulting in difficulty achieving a good seal of the ostomy pouching system. To overcome these challenges, a multidisciplinary approach with WOC nurses, colorectal surgeons, and plastic surgeons was implemented. Initially, the defect was managed with a negative pressure wound therapy system, followed by a primary closure of the peristomal skin by the plastic surgeons. Mr T was discharged to home 58 days after his initial surgery; by that time, the peristomal skin was healed and he was able to manage ostomy pouching changes independently. Eight months later his ileostomy was successfully reversed.
   CONCLUSIONS: Large peristomal defects are challenging but can be managed successfully via a multidisciplinary approach including WOC nurses, colorectal surgeons, and plastic surgeons.
C1 [van Kessel, Charlotte S.; Young, Christopher J.] Royal Pnnce Alfred Hosp, Dept Colorectal Surg, Sydney, NSW, Australia.
   [Mendes, Colleen] Royal Prince Alfred Hosp, Dept Stomal Therapy, Sydney, NSW, Australia.
C3 University of Sydney; NSW Health; Royal Prince Alfred Hospital
RP van Kessel, CS (通讯作者)，Royal Prince Alfred Hosp, Surg Outcome & Res Unit, Sydney, NSW, Australia.
EM charlottevankessel@hotmail.com
RI Young, Christopher John/JTZ-5903-2023
OI Young, Christopher John/0000-0002-7213-5137
CR Agarwal S, 2010, DERMATITIS, V21, P138, DOI 10.2310/6620.2010.09103
   Antony S, 2004, J NATL MED ASSOC, V96, P1073
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   Arumugam P J, 2003, Colorectal Dis, V5, P49, DOI 10.1046/j.1463-1318.2003.00403.x
   Braumann C, 2019, WORLD J SURG, V43, P751, DOI 10.1007/s00268-018-4846-9
   CARLSTEDT A, 1987, INT J COLORECTAL DIS, V2, P22, DOI 10.1007/BF01648993
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Chun LJ, 2012, DIS COLON RECTUM, V55, P167, DOI 10.1097/DCR.0b013e31823a9761
   Colwell JC, 2022, J WOUND OSTOMY CONT, V49, P240, DOI 10.1097/WON.0000000000000874
   Doud AN, 2016, ANN SURG ONCOL, V23, P503, DOI 10.1245/s10434-015-4674-1
   Jacquet P, 1996, Cancer Treat Res, V82, P359
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   Ratliff CR, 2021, J WOUND OSTOMY CONT, V48, P219, DOI 10.1097/WON.0000000000000758
   Saghir JH, 2001, EUR J SURG, V167, P531
   Sankar A, 2014, BRIT J ANAESTH, V113, P424, DOI 10.1093/bja/aeu100
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NR 19
TC 0
Z9 0
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD NOV-DEC
PY 2022
VL 49
IS 6
BP 564
EP 569
DI 10.1097/WON.0000000000000914
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 8R9XV
UT WOS:000928240300012
PM 36417381
DA 2026-07-24
ER
PT J
AU Du, Y
   Han, S
   Zhou, Y
   Chen, HF
   Lu, YL
   Kong, ZY
   Li, WP
AF Du, Yao
   Han, Song
   Zhou, Yue
   Chen, Hai Feng
   Lu, Yao Liang
   Kong, Zhi Yuan
   Li, Wei Ping
TI Severe wound infection by MRCNS following bilateral inguinal
   herniorrhaphy
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE MRCNS; Wound infection; Hernia; Inguinal
ID SURGICAL SITE INFECTIONS; ANTIBIOTIC-PROPHYLAXIS; HERNIA; EPIDEMIOLOGY;
   PREVENTION; GUIDELINES
AB BackgroundWound infection after inguinal hernia surgery is not uncommon in the clinical setting. The common microbial aetiology of postoperative inguinal hernia wound infection is Gram-positive bacteria. Staphylococcus aureus is a common pathogen causing wound infection while Staphylococcus epidermidis and Pseudomonas are rare. Staphylococcus epidermidis as a cause of severe wound infection is rarely described in literature. We herein present a case of a 79-year-old man with a rare wound infection after bilateral inguinal herniorrhaphy caused by MRCNS (Methicillin Resistant Coagulase Negative Staphylococcus).Case presentationWe present a case of wound infection accompanied by fever with a temperature of 38.8 degrees C after bilateral inguinal herniorrhaphy in a 79-year-old man. Bilateral inguinal wounds were marked by redness and swelling, with skin necrosis. In addition, an abscess of approximately 1.5 cm x 1.5 cm was seen on the left wrist. A small amount of gas under the skin in the wound area was observed after pelvic computed tomography (CT) scans. No bacteria were cultured from the inguinal wound discharge, while blood culture detected MRCNS, and Acinetobacter lwoffi was cultured from the pus in the left wrist. We chose appropriate antibiotics based on the results of the bacterial culture and the drug susceptibility results. Vacuum assisted closure (VAC) therapy was used after debridement. The patient was discharged after the wounds improved. He was followed up for ten months and showed no signs of complications. We are sharing our experience along with literature review.ConclusionsWe are presenting a rare case of MRCNS wound infection following open inguinal hernia surgery. Although a rarity, clinicians performing inguinal hernia surgery must consider this entity in an infected wound and follow up the patient for complications of MRCNS.
C1 [Du, Yao; Han, Song; Zhou, Yue; Lu, Yao Liang; Kong, Zhi Yuan; Li, Wei Ping] Soochow Univ, Peoples Hosp Taicang City 1, Dept Gen Surg, Taicang Affiliated Hosp, Taicang City 215400, Jiangsu, Peoples R China.
   [Du, Yao] Nanchang Univ, Dept Gen Surg, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China.
   [Chen, Hai Feng] Soochow Univ, Peoples Hosp Taicang City 1, Dept Gastroenterol, Taicang Affiliated Hosp, Taicang City 215400, Jiangsu, Peoples R China.
C3 Soochow University - China; Nanchang University; Soochow University -
   China
RP Li, WP (通讯作者)，Soochow Univ, Peoples Hosp Taicang City 1, Dept Gen Surg, Taicang Affiliated Hosp, Taicang City 215400, Jiangsu, Peoples R China.
EM question12397@163.com
OI Li, Weiping/0000-0003-0729-4438
FU Suzhou Municipal Science and Technology Bureau [TC2021JCYL21] Funding
   Source: Medline
CR Breurec S, 2011, CLIN MICROBIOL INFEC, V17, P160, DOI 10.1111/j.1469-0691.2010.03219.x
   Cai LZ, 2018, SURG INFECT, V19, P11, DOI 10.1089/sur.2017.154
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NR 18
TC 1
Z9 2
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD FEB 7
PY 2023
VL 23
IS 1
AR 85
DI 10.1186/s12879-023-08039-9
PG 6
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 8T1XO
UT WOS:000929062200008
PM 36750769
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ren, B
   Jiang, XJ
   Chen, J
   Mo, JJ
AF Ren, Bei
   Jiang, XiaoJuan
   Chen, Jin
   Mo, JunJun
TI The efficacy of negative pressure wound therapy after
   hepatopancreatobiliary surgery: A systematic review and meta-analysis
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Review
DE Surgical site infection; Seroma; hematoma; Negative pressure wound
   therapy; Morbidity; Hospital re-admission
ID SURGICAL SITE INFECTION; CLOSED INCISION MANAGEMENT; RISK-FACTORS;
   HEPATOBILIARY; RATES
AB Objective: To evaluate the comparative influence of NPT and standard surgical dressing administration on incidence risk for surgical site infections, complications, and hospital readmission after hepatopancreatobiliary surgery.
   Methods: Five databases were systematically searched according to PRISMA guidelines. These databases included Web of Science, MEDLINE, CENTRAL, EMBASE, and Scopus for eligible studies published prior to March 2021. With eligible studies, we conducted a random-effects meta-analysis to evaluate comparative outcomes such as superficial surgical infection, deep surgical infection, seroma incidence, hematoma incidence, and hospital re-admission in patients receiving NPT or standard surgical dressings after hepatopancreatobiliary surgery.
   Results: The search strategy yielded 963 studies, with six studies meeting inclusion criteria. Odds of superficial surgical site infection ( OR: 1.58), deep surgical site infection (1.43), seroma complication (1.64), hematoma complication (0.40) were insignificantly different between patients receiving NPT and standard surgical dressing. The odds of hospital re-admission rate (2.37), however, were elevated in patients receiving standard surgical dressing relative to those receiving NPT.
   Conclusion: This meta-analysis shows that NPT usage slightly reduces risk of hospital readmission as compared to standard surgical dressing. We did not observe any significant effect of NPT on superficial, deep surgical infections, seroma, and haematoma outcomes following hepatopancreatobiliary surgery. These findings may aid clinicians in stratifying risk and selecting treatment strategy in patients undergoing hepatopancreatobiliary surgery.
C1 [Ren, Bei] First Peoples Hosp Wenling, Dept Wound Stoma Outpatient Care, Wenling, Zhejiang, Peoples R China.
   [Jiang, XiaoJuan] First Peoples Hosp Wenling, Dept Endocrinol, Wenling, Zhejiang, Peoples R China.
   [Chen, Jin] First Peoples Hosp Wenling, Outpatient Management Off, Wenling, Zhejiang, Peoples R China.
   [Mo, JunJun] First Peoples Hosp Wenling, Dept PICC Outpatient, Wenling, Zhejiang, Peoples R China.
RP Mo, JJ (通讯作者)，First Peoples Hosp Wenling, Dept PICC Outpatient, 333 Chuanan South Rd,Chengxi St, Wenling 317500, Zhejiang, Peoples R China.
EM mojunjun1106@163.com
CR Andrianello S, 2021, SURGERY, V169, P1069, DOI 10.1016/j.surg.2020.10.029
   Arti H, 2016, PAK J MED SCI, V32, P65, DOI 10.12669/pjms.321.8568
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Bax L, 2007, BMC MED RES METHODOL, V7, DOI 10.1186/1471-2288-7-40
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
   Brace JA, 2007, J WOUND OSTOMY CONT, V34, P428, DOI 10.1097/01.WON.0000281661.77086.d1
   Brennfleck FW, 2021, INT WOUND J, V18, P17, DOI 10.1111/iwj.13511
   Ceppa EP, 2013, HPB, V15, P384, DOI 10.1111/j.1477-2574.2012.00604.x
   de Laat EHEW, 2011, ANN PLAS SURG, V67, P626, DOI 10.1097/SAP.0b013e31820b3ac1
   Duval S, 2000, BIOMETRICS, V56, P455, DOI 10.1111/j.0006-341X.2000.00455.x
   Ejaz A, 2017, J SURG RES, V217, P153, DOI 10.1016/j.jss.2017.05.018
   Gupta R, 2017, AM SURGEON, V83, P1166
   Harmon LJ, 2005, EVOLUTION, V59, P2705
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   Hozo S., 2005, BMC MED RES METHODOL, V5, P13, DOI DOI 10.1186/1471-2288-5-13
   Isik O, 2015, SURG INFECT, V16, P281, DOI 10.1089/sur.2013.195
   Javed AA, 2019, ANN SURG, V269, P1034, DOI 10.1097/SLA.0000000000003056
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   Morikane K, 2017, SURG TODAY, V47, P1208, DOI 10.1007/s00595-017-1503-0
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   OLENIUS M, 1993, PLAST RECONSTR SURG, V91, P213, DOI 10.1097/00006534-199302000-00001
   Othman Diaa, 2012, Plast Surg Int, V2012, P374398, DOI 10.1155/2012/374398
   Parikh P, 2010, HPB, V12, P488, DOI 10.1111/j.1477-2574.2010.00216.x
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   Sterne JAC, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i4919
   Suissa D, 2011, PLAST RECONSTR SURG, V128, p498E, DOI 10.1097/PRS.0b013e31822b675c
   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
NR 32
TC 2
Z9 2
U1 0
U2 2
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
EI 1681-715X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD NOV-DEC
PY 2022
VL 38
IS 8
BP 2356
EP 2364
DI 10.12669/pjms.38.8.6601
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8T6SY
UT WOS:000929390200003
PM 36415224
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Frodl, A
   Geisteuer, N
   Fuchs, A
   Nymark, T
   Schmal, H
AF Frodl, A.
   Geisteuer, N.
   Fuchs, A.
   Nymark, T.
   Schmal, H.
TI Incisional negative pressure wound therapy to reduce surgical-site
   infections in major limb amputations: a meta-analysis
SO EFORT OPEN REVIEWS
LA English
DT Article
DE iNPWT; major amputation; wound therapy
ID VACUUM-ASSISTED CLOSURE; MORTALITY
AB Purpose: Incisional negative pressure wound therapy (iNPWT) has shown effectiveness in the treatment of high-risk surgical wounds. Especially patients with diabetes-induced peripheral arterial disease undergoing major limb amputation have a high intrinsic risk for post-surgical wound infections. While normal gauze wound dressings do not cause stimulation of microvasculature, iNPWT might improve wound healing and reduce wound complications. The purpose of this study was to systematically review the literature for rates of wound complications and readmissions, as well as post-surgical 30-day mortality.
   Methods: We conducted a systematic review searching the Cochrane, PubMed, and Ovid databases. Inclusion criteria were the modified Coleman methodology Score >60, nontraumatic major limb amputation, and adult patients. Traumatic amputations and animal studies were excluded. Relevant articles were reviewed independently by referring to the title and abstract. In a meta-analysis, we compared 3 studies and 457 patients.
   Results: A significantly overall lower rate of postoperative complications is associated with usage of iNPWT (odds ratio (OR) = 0.52; 95% CI: 0.30-0.89; P = 0.02). There was no significant improvement for 30-day mortality, when iNPWT was used (OR= 081; 95% CI: 0.46 - 1.45; P = 0.48). Nevertheless, we did not note a significant difference in the readmission rate or revision surgery between the two groups.
   Conclusion: Overall, the usage of iNPWT may reduce the risk of postoperative wound complications in major lower limb amputations but does not improve 30-day mortality rates significantly. However, to anticipate surgical-site infection, iNPWT has shown effectiveness and thus should be used whenever applicable.
C1 [Frodl, A.; Fuchs, A.; Schmal, H.] Freiburg Univ Hosp, Dept Orthoped & Traumatol, Freiburg, Germany.
   [Geisteuer, N.] Asklepios Hosp Harburg, Dept Orthoped & Traumatol, Hamburg, Germany.
   [Nymark, T.; Schmal, H.] Univ Hosp Odense, Dept Orthoped Surg, Odense C, Denmark.
C3 University of Freiburg; University of Southern Denmark; Odense
   University Hospital
RP Frodl, A (通讯作者)，Freiburg Univ Hosp, Dept Orthoped & Traumatol, Freiburg, Germany.
EM Andreas.Frodl@uniklinik-freiburg.de
RI Schmal, Hagen/B-2684-2016
OI Frodl, Andreas/0000-0002-3899-9345; Nymark, Tine/0000-0002-7474-0701
FU University of Freiburg [DE142116817]; Baden-Wuerttemberg Ministry of
   Science, Research and Art
FX The article processing charge will be funded by the Baden-Wuerttemberg
   Ministry of Science, Research and Art and the University of Freiburg in
   the funding program Open Access Publishing (DE142116817).
CR Achten J, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-022115
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   Caro A, 2011, INT WOUND J, V8, P274, DOI 10.1111/j.1742-481X.2011.00782.x
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   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
   Zayan NE, 2019, ADV WOUND CARE, V8, P368, DOI 10.1089/wound.2018.0935
   Ziran Bruce, 2005, Am J Orthop (Belle Mead NJ), V34, P329
NR 31
TC 9
Z9 12
U1 0
U2 2
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 2396-7544
EI 2058-5241
J9 EFORT OPEN REV
JI EFORT Open Rev.
PD AUG
PY 2022
VL 7
IS 8
BP 526
EP 532
DI 10.1530/EOR-22-0049
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 8U2HV
UT WOS:000929772000001
PM 35924636
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fout, B
   Plotzke, M
AF Fout, Betty
   Plotzke, Michael
TI Comparing Traditional and Disposable Negative-Pressure Wound Therapy Use
   by Medicare Home Health Patients
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE disposable; home health; Medicare; negative-pressure wound therapy;
   NPWT; traditional; wound care
AB OBJECTIVESince 2017, home health agencies (HHAs) have received reimbursement for the provision of negative-pressure wound therapy (NPWT) using disposable, portable devices to eligible Medicare fee-for-service beneficiaries. This study aimed to describe the use of disposable NPWT (dNPWT) versus traditional, durable medical equipment-based NPWT (tNPWT) in the home health setting over time and compare the types of beneficiaries using and associated Medicare payments for NPWT separate from the home health payment bundle.METHODSMedicare fee-for-service claims were used to identify beneficiaries receiving NPWT from HHAs during home health stays. Assessment and Medicare administrative data were linked to compare characteristics between those receiving tNPWT or dNPWT and to calculate and contrast average Medicare payments for NPWT provided during the home health episode.RESULTSIn 2019, the vast majority of NPWT used was tNPWT (>99%). Beneficiaries using dNPWT had fewer health risk factors and used substantially less medical care than beneficiaries using tNPWT ($47,187 vs $60,440 in annual total Medicare payments per beneficiary). However, the average Medicare payments for dNPWT exceeded that of tNPWT ($1,624 vs $899) during a home health episode.CONCLUSIONSAlthough dNPWT is well-suited for the home, its uptake has been slow. This may be attributable to HHAs' confusion in billing for dNPWT or differences in the wound types appropriate for dNPWT versus tNPWT. Policymakers should continue to monitor the use of dNPWT in the home health setting, especially given the greater average Medicare payment of dNPWT per episode.
CR [Anonymous], 2017, GAO-17-600
   [Anonymous], 2019, Home Health Services Payment System
   [Anonymous], 2019, Clarification of Billing and Payment Policies for Negative Pressure Wound Therapy (NPWT) Using a Disposable Device
   Banasiewcz T., 2019, WOUNDS INT, V10
   Centers for Medicare & Medicaid Services, 2021, DMEPOS FEE SCHED
   Centers for Medicare & Medicaid Services, 2018, REP C RISK ADJ MED A
   Centers for Medicare Medicaid Services, 2016, FED REGISTER, V81, P76702
   Centers for Medicare & Medicaid Services, 2021, MED CLAIMS PROC MAN
   Harding K., 2017, ROLE MECHANICALLY PO
   Hudson DA, 2015, INT WOUND J, V12, P195, DOI 10.1111/iwj.12080
   Intermountain Healthcare, 2018, NEG PRESS WOUND THER
   Medicare Hospital Outpatient Prospective Payment System, 2019, ADD A ADD B UPD
   Schaum K., 2015, CLIN IMMUNOL, V9
   Schaum K., 2019, WATER AIR SOIL POLL, V32
   US Government Accountability Office, 2019, MED SPEND CERT DISP
   Wound Care Centers, NEG PRESS WOUND THER
NR 16
TC 4
Z9 4
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2022
VL 35
IS 1
BP 37
EP 42
DI 10.1097/01.ASW.0000801536.61163.e5
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 8W7IY
UT WOS:000931502800010
PM 34935720
DA 2026-07-24
ER
PT J
AU Klein, DS
   Yingling, JM
   Patel, P
   Capo, JT
AF Klein, David S.
   Yingling, John M.
   Patel, Priya
   Capo, John T.
TI Vacuum-Assisted Therapy for Combined Volar-Dorsal Soft-Tissue Defects of
   the Hand: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE glove; hand; negative-pressure wound therapy; NPWT; soft-tissue defect;
   trauma; vacuum-assisted closure; wound
ID CLOSURE; THUMB
AB Application of negative-pressure wound therapy dressings to the web spaces and small, often moist, areas of the hand can be technically demanding and time consuming. The researchers present a case report and technique for managing a devastating hand infection and soft-tissue defects by creating a self-fabricated sponge glove that is easily reproducible. Vacuum-assisted therapy for combined volar dorsal soft-tissue defects of the hand, or "Hand Vac," is a novel approach for treating extensive hand wounds. This technique was used in a patient with diabetes with a deep space infection of the hand following serial debridements and antibiotic bead therapy. A single, medium-size sponge was cut using a knife and scissors to create an easily applied glove that was then sealed with adhesive dressing and a single suction port. The patient avoided complete amputation of the hand and deep infection was eradicated. The wounds had progressive granulation and healing and were eventually covered with split-thickness skin grafts. The authors conclude that severe soft-tissue defects involving both the volar and dorsal aspects of the hand can be effectively managed with a single glove-like sponge and suction port.
C1 [Klein, David S.] Morristown Med Ctr, Tri Cty Orthoped, Dept Orthoped Surg, Cedar Knolls, NJ 07960 USA.
   [Yingling, John M.] Jersey City Med Ctr RWJBarnabas Hlth, Dept Orthoped Surg, Jersey City, NJ USA.
   [Patel, Priya] Jersey City Med Ctr RWJBarnabas Hlth, Hand Surg, Jersey City, NJ USA.
   [Capo, John T.] Jersey City Med Ctr RWJBarnabas Hlth, Div Hand Surg, Jersey City, NJ USA.
C3 Atlantic Health System
RP Klein, DS (通讯作者)，Morristown Med Ctr, Tri Cty Orthoped, Dept Orthoped Surg, Cedar Knolls, NJ 07960 USA.
CR Aras A, 2016, J CLIN DIAGN RES, V10, pPD19, DOI 10.7860/JCDR/2016/18485.7659
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   Chen LH, 2015, MEDICINE, V94, P1, DOI 10.1097/MD.0000000000001575
   Elliot D, 2018, J HAND SURG-EUR VOL, V43, P1019, DOI 10.1177/1753193418805698
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   Gage MJ, 2015, ORTHOP CLIN N AM, V46, P227, DOI 10.1016/j.ocl.2014.11.002
   Germann G, 2017, J HAND SURG-AM, V42, P274, DOI 10.1016/j.jhsa.2017.01.022
   Kang GCW, 2008, INT WOUND J, V5, P45, DOI 10.1111/j.1742-481X.2007.00369.x
   Kasukurthi Rahul, 2010, Hand (N Y), V5, P95, DOI 10.1007/s11552-009-9209-4
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NR 18
TC 1
Z9 1
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2022
VL 35
IS 1
BP 57
EP 61
DI 10.1097/01.ASW.0000771980.02715.5c
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 8W7IY
UT WOS:000931502800013
PM 34412063
DA 2026-07-24
ER
PT J
AU Betz, V
   van Ackeren, V
   Scharsack, E
   Stark, B
   Müller, CT
   Loske, G
AF Betz, Viktoria
   van Ackeren, Vera
   Scharsack, Ernst
   Stark, Bettina
   Mueller, Christian Theodor
   Loske, Gunnar
TI Intrathoracic negative pressure therapy of pleural empyema using an
   open-pored drainage film
SO CHIRURGIE
LA German
DT Article
DE Primary intervention; Complications; Drainage element; Polyurethane
   foam; Dressing change
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; PERFORATION
AB Introduction: We report our initial experience with intrathoracic negative pressure therapy (ITNPT) in the stage-adjusted therapy of pleural empyema (PE) based on a case series.Materials and Methods: ITNPT represents a further development in negative pressure therapy that is designed to be used in the thoracic cavity. After thoracic surgical open debridement, an intrathoracic negative pressure dressing was inserted. The drainage elements used were a thin open-pore double-layer drainage film (OF) with open-pore polyurethane foams (PUF). Only the OF was placed in direct contact with the lung parenchyma. Negative pressure was generated using an electronic pump (continuous suction, -75 mm Hg). In revision thoracotomies, ITNPT was stopped or continued depending on local findings.Results: 31 patients with stage II and III pleural empyemas were treated. ITNPT was administered at the time of primary procedure (n = 17) or revision (n = 14). ITNPT was given over a duration of m = 10 days (2-18 days), change interval m = 4 d (2-6 d). The application of intrathoracic negative pressure dressings was performed m = 3.5 (1-6) times.The empyema cavity continuously reduced in size and was cleansed by the suction. The OF has a minimum intrinsic volume with maximum absorption surface. Once negative pressure is established, there is no intrathoracic dead volume and the parenchyma can expand.Discussion: The protective material properties of OF make ITNPT suitable for the treatment of pleural empyema. Targeted local intrathoracic drainage of the septic focus is a possible adjunct to surgery. The treatment regimen requires surgical dressings to be changed repeatedly. The method is suitable for the treatment of complex stage II and III pleural empyemas.Conclusion: The OF can be used as an intrathoracic drainage element for ITNPT in pleural empyema. This new application option expands the range of indications for negative pressure therapy.
C1 [Betz, Viktoria; van Ackeren, Vera; Scharsack, Ernst; Stark, Bettina; Mueller, Christian Theodor; Loske, Gunnar] Katholisches Marienkrankenhaus gGmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
C3 St. Marien Hospital
RP Betz, V (通讯作者)，Katholisches Marienkrankenhaus gGmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
EM viktoria.betz@web.de
CR Adams O, S2K LEITLINIE MANAGE
   Munguía-Canales DA, 2013, ARCH BRONCONEUMOL, V49, P447, DOI 10.1016/j.arbres.2012.11.003
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NR 30
TC 2
Z9 2
U1 1
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2731-6971
EI 2731-698X
J9 CHIRURGIE
JI Chirurgie
PD APR
PY 2023
VL 94
IS 4
SI SI
BP 349
EP 360
DI 10.1007/s00104-022-01800-x
EA FEB 2023
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA C2AB1
UT WOS:000931710400001
PM 36754892
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Patterson, JT
   Becerra, JA
   Brown, M
   Roohani, I
   Zalavras, C
   Carey, JN
AF Patterson, Joseph T.
   Becerra, Jacob A.
   Brown, Michael
   Roohani, Idean
   Zalavras, Charalampos
   Carey, Joseph N.
TI Antibiotic bead pouch versus negative pressure wound therapy at initial
   management of AO/OTA 42 type IIIB open tibia fracture may reduce
   fracture related infection: A retrospective analysis of 113 patients
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Open fracture; Tibia; Shaft; Diaphysis; Antibiotic; Beads; Bead pouch;
   Negative pressure wound therapy; Wound vacuum; Infection
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY TRAUMA; MICROSURGICAL
   RECONSTRUCTION; FLAP COVERAGE; DELAY; PROPHYLAXIS; DEBRIDEMENT;
   EFFICACY; TRIAL; LIMB
AB Introduction: Fracture related infection (FRI) may be a devastating complication of open tibial shaft frac-tures. We sought to determine if antibiotic bead pouch, negative pressure wound therapy, or negative pressure wound therapy over antibiotic beads as the initial coverage method for type IIIB open tibial shaft fractures is associated with risk of FRI.Patients and methods: Retrospective cohort study with radiograph and chart review of patients aged >= 16 years with isolated, displaced, extra-articular, Gustilo-Anderson type IIIB open diaphyseal AO/OTA 42 tib-ial fractures requiring rotational or free tissue transfer for soft tissue coverage at one Level 1 trauma cen-ter between 2007 and 2020. An association of dressing applied at the first surgical debridement (appli-cation of antibiotic bead pouch, negative pressure wound therapy, or combined therapy) with a primary outcome of FRI requiring debridement or amputation was analyzed by multivariable logistic regression considering demographic, injury, and treatment characteristics.Results: 113 patients met eligibility criteria. Median follow-up was 33 months (interquartile range 5- 88). 41 patients were initially treated with NPWT, 59 with ABP, and 13 with ABP + NPWT at the initial surgical debridement. 39 (35%) underwent subsequent debridement or amputation for FRI. One ampu-tation occurred in the ABP group for refractory deep surgical site infection ( p = 0.630). Initial wound management with an antibiotic bead pouch versus either negative pressure wound therapy alone or neg-ative pressure wound therapy combined with an antibiotic bead pouch was associated with lower odds of debridement or amputation for FRI (beta =-1.08, 95% CI-2.00 to-0.17, p = 0.02).Conclusions: In our retrospective analysis, antibiotic bead pouch for initial coverage of type IIIB open tibial shaft fractures requiring flap coverage was associated with a lower risk of FRI requiring debride-ment or amputation than negative pressure wound therapy applied with or without antibiotic beads. A prospective clinical trial is warranted.(c) 2022 Elsevier Ltd. All rights reserved.
C1 [Patterson, Joseph T.; Becerra, Jacob A.; Brown, Michael; Zalavras, Charalampos] Univ Southern Calif, Keck Sch Med, Dept Orthopaed Surg, Los Angeles, CA USA.
   [Roohani, Idean; Zalavras, Charalampos; Carey, Joseph N.] Univ Southern Calif, Keck Sch Med, Dept Surg, Div Plast Surg, Los Angeles, CA USA.
   [Patterson, Joseph T.] Univ Southern Calif, Keck Sch Med, Dept Orthopaed Surg, 1520 San Pablo St,Suite 2000, Los Angeles, CA 90033 USA.
C3 University of Southern California; University of Southern California;
   University of Southern California
RP Patterson, JT (通讯作者)，Univ Southern Calif, Keck Sch Med, Dept Orthopaed Surg, 1520 San Pablo St,Suite 2000, Los Angeles, CA 90033 USA.
EM josephp7@usc.edu
OI Zalavras, Charalampos/0000-0002-7576-3374; Becerra,
   Jacob/0000-0002-9171-2374; Patterson, Joseph/0000-0002-7494-7366
CR Bhandari M, 2008, J BONE JOINT SURG AM, V90A, P2567, DOI 10.2106/JBJS.G.01694
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NR 39
TC 10
Z9 14
U1 0
U2 4
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2023
VL 54
IS 2
BP 744
EP 750
DI 10.1016/j.injury.2022.12.018
EA FEB 2023
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 8X2YE
UT WOS:000931882200001
PM 36588031
DA 2026-07-24
ER
PT J
AU Xie, HF
   Guo, ZD
   Cao, Q
   Ye, Y
   Chen, L
   Luo, N
AF Xie, Huifang
   Guo, Zhaodi
   Cao, Qin
   Ye, Yuan
   Chen, Li
   Luo, Na
TI Effect of individualized comfortable nursing on prognosis of vacuum
   sealing drainage in patients with orthopedic trauma
SO MEDICINE
LA English
DT Article
DE comfort care; efficacy; orthopedic trauma; vacuum sealing drainage
ID WOUND-INFECTION; EFFICACY; SAFETY; WORLD
AB To explore the effect of individualized comfortable nursing on prognosis of vacuum sealing drainage (VSD) in patients with orthopedic trauma. 110 patients with orthopedic trauma VSD were randomly divided into the control group and the observation group, with 55 patients in each group receiving routine care and comfortable care. The wound healing time, visual analog scale, quality of life score, the level of inflammatory factors, the incidence of complications, and patient satisfaction were compared between the 2 groups. The average time of wound healing in the observation group was significantly lower than that in the control group (P < .01). The satisfaction rate in the observation group was significantly higher than that in the control group (P = .029). Meanwhile, the results showed that visual analog scale and quality of life scores in the observation group was significantly improved than that of the control group after receiving intervention (P < .05). After receiving intervention, the levels of TNF-alpha and IL-6 of patients in both groups were decreased, and the levels of TNF-alpha and IL-6 in the observation group were significantly decreased than those in the control group. Moreover, the incidence rate of adverse reaction in the observation group was significantly lower than that in the control group (P < .01). Comfortable nursing can reduce the wound healing time, the postoperative pain level, the incidence of complications, and improve patient satisfaction, which is of great significance for the prognosis of VSD in patients with orthopedic trauma.
C1 [Xie, Huifang; Guo, Zhaodi; Cao, Qin; Ye, Yuan; Chen, Li; Luo, Na] Huazhong Univ Sci & Technol, Union Jiangnan Hosp, Peoples Hosp Jiangxia Dist 1, Dept Hand Surg, Wuhan, Hubei, Peoples R China.
   [Luo, Na] Huazhong Univ Sci & Technol, Union Jiangnan Hosp, Peoples Hosp Jiangxia Dist 1, Dept Hand Surg, Wuhan 430200, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Luo, N (通讯作者)，Huazhong Univ Sci & Technol, Union Jiangnan Hosp, Peoples Hosp Jiangxia Dist 1, Dept Hand Surg, Wuhan 430200, Hubei, Peoples R China.
EM 547205506@qq.com; 353863698@qq.com; 17741348@qq.com; 1570335858@qq.com;
   21698770@qq.com; 13100688627@163.com
RI luo, na/KOC-3893-2024
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NR 26
TC 0
Z9 1
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 17
PY 2023
VL 102
IS 7
DI 10.1097/MD.0000000000032903
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9B4PM
UT WOS:000934720400029
PM 36800609
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Huang, T
   Liu, T
   Shang, M
   Han, G
AF Huang, Tao
   Liu, Tong
   Shang, Mei
   Han, Gang
TI Clinical application of improved VSD and VSD in the treatment of SSI
   after abdominal surgery: A retrospective randomized clinical study
SO MEDICINE
LA English
DT Article
DE abdominal surgery; improved vacuum sealing drainage; surgical site
   infection; vacuum sealing drainage
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; PRESSURE WOUND
   THERAPY; RISK-FACTORS; OPEN ABDOMEN; MANAGEMENT; SYSTEM
AB By comparing the efficacy and cost of improved vacuum-sealing drainage devices and vacuum-sealing drainage (VSD) devices in the treatment of postoperative abdominal surgical site infection, the clinical applicability and promotion of improved vacuum-sealing drainage devices were assessed. In our institution, between October 2019 and December 2021, 55 patients with surgical site infection after abdominal surgery were retrospectively analyzed, including 30 patients treated with improved VSD and 25 patients treated with VSD. The efficacy of wound healing, total dressing change cost throughout therapy, total hospital costs, hospital days, and bacterial culture results of wound secretions before and after treatment were compared between the 2 groups. Both groups achieved wound healing following vacuum sealing-drainage treatment, with no significant differences in wound healing time or secondary suture rate. However, the total hospitalization and dressing change costs in the improved VSD group were significantly lower than those in the VSD group. Similar to VSD, improved VSD is effective in the treatment of surgical site infections after abdominal surgery. Compared with VSD, the improved VSD device has lower dressing change costs and total hospitalization costs during the treatment process. The improved VSD has a wide range of applications and is suitable for clinical use and promotion.
C1 [Huang, Tao] Wuhan Puren Hosp, Dept Gastrointestinal Surg, Wuhan, Hubei, Peoples R China.
   [Liu, Tong; Shang, Mei; Han, Gang] Jilin Univ, Hosp 2, Dept Gastrointestinal Nutr & Hernia Surg, Changchun, Jilin, Peoples R China.
C3 Jilin University
RP Han, G (通讯作者)，Jilin Univ, Hosp 2, Dept Gastrointestinal Nutr & Hernia Surg, Changchun, Jilin, Peoples R China.
EM huangtao19@mails.jlu.edu.cn; liutong19@mails.jlu.edu.cn;
   1072839343@qq.com; hangang@jlu.edu.cn
OI Huang, Tao/0000-0002-0879-1850
FU Jilin Science and Technology Department Medical Department Project
   [20160101092JC]
FX This study was supported by the Jilin Science and Technology Department
   Medical Department Project (20160101092JC).
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   Sahebally SM, 2018, JAMA SURG, V153, DOI 10.1001/jamasurg.2018.3467
   Scalise A, 2016, INT WOUND J, V13, P1260, DOI 10.1111/iwj.12492
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
   Wondberg D, 2008, WORLD J SURG, V32, P2724, DOI 10.1007/s00268-008-9762-y
NR 24
TC 5
Z9 5
U1 2
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 10
PY 2023
VL 102
IS 6
DI 10.1097/MD.0000000000032785
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9C7RE
UT WOS:000935609400019
PM 36820532
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lee, SK
   An, YS
   Choy, WS
AF Lee, Sang Ki
   An, Young Sun
   Choy, Won Sik
TI Management of Hardware-Exposed Soft Tissue Defects Using Dermal
   Substitutes and Negative Pressure Wound Therapy
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE artificial dermis; negative-pressure wound therapy; hardware-exposed
   wounds; skin grafting
ID RECONSTRUCTION
AB IntroductionReconstruction of complex injuries of the extremities with full-thickness wounds is a challenging but important task. If primary closure is not feasible, more complex procedures are required, such as split-thickness skin graft or flap surgery. Recently, several studies have shown good results when combined with negative pressure wound therapy (NPWT) and artificial dermal replacement therapy after extensive surgical debridement and NPWT administration for severe complex wounds accompanied by tendon or bone exposure. However, flap surgery remains the only treatment for wounds in which the hardware is exposed after fracture fixation. Therefore, in this study, we attempted to prove the usefulness of the combined treatment using artificial dermal substitutes (MatriDerm) and NPWT by focusing on hardware-exposed wounds, which have not been studied before.MethodsFrom 2019 to 2021, we treated with our wound management procedure 14 patients with hardware-exposing wounds after internal fixation using plates, out of 48 patients with full-thickness posttraumatic skin defect. Before skin grafting, after surgical debridement and thorough washouts, MatriDerm was placed and NPWT was applied over it. This staged approach aimed at conditioning even the most complex wounds so that closure with MatriDerm-augmented skin grafting would become possible in a one-step approach.ResultsWe stratified the duration of treatment and number of replacements in NPWT according to the type of injury. Cases with open fractures required significantly longer NPWT than those with closed fractures (P = 0.01); however, there was no significant difference between the Gustilo-Anderson classification within open fractures (P > 0.05). Patients with open fractures underwent a mean of 6.6 changes while those with closed fractures underwent 2.5 (P = 0.002) until the final wound closure with MatriDerm-augmented skin grafting was performed. There was no significant difference in the treatment period based on the location and size of the wound, and there was no significant difference in the number of NPWT replacements. Skin grafting was successful in all 14 patients.ConclusionsThis study revealed that NPWT and artificial dermis-augmented skin grafting after combined treatment with NPWT and artificial dermis were sufficiently useful for hardware-exposed wounds, where flap surgery has been considered the only treatment to date.
C1 [Lee, Sang Ki; An, Young Sun; Choy, Won Sik] Eulji Univ, Coll Med, Dept Orthoped Surg, Daejeon, South Korea.
   [Lee, Sang Ki] Dept Orthoped Surg, 1306 Dunsan Dong, Daejeon 35233, South Korea.
C3 Eulji University
RP Lee, SK (通讯作者)，Dept Orthoped Surg, 1306 Dunsan Dong, Daejeon 35233, South Korea.
EM sklee@eulji.ac.kr; nervcobe@naver.com; orthoplsk@naver.com
CR Cervelli V, 2011, INT WOUND J, V8, P400, DOI 10.1111/j.1742-481X.2011.00806.x
   Choi JY, 2014, ARCH PLAST SURG-APS, V41, P337, DOI 10.5999/aps.2014.41.4.337
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NR 19
TC 5
Z9 6
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAR
PY 2023
VL 90
IS 3
BP 242
EP 247
DI 10.1097/SAP.0000000000003440
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9D3BJ
UT WOS:000935975600010
PM 36796046
DA 2026-07-24
ER
PT J
AU Bueno-Lledó, J
   Martinez-Hoed, J
   Bonafe-Diana, S
   Pous-Serrano, S
AF Bueno-Lledo, Jose
   Martinez-Hoed, Jesus
   Bonafe-Diana, Santiago
   Pous-Serrano, Salvador
TI Mesh Infection After Hernia Repair and Negative Pressure Wound Therapy.
   A Systematic Review
SO WORLD JOURNAL OF SURGERY
LA English
DT Review
ID MANAGEMENT; COMPLICATIONS; SURGERY
AB BackgroundSurgical mesh infection (SMI) after abdominal wall hernia repair (AWHR) is a challenging and highly debatedclinical problem with no current consensus. The purpose of this review was to analyze the literature about the useof negative pressure wound therapy (NPWT) in the management of the conservative treatment of SMI and reportresults about infected mesh salvage.MethodsA systematic review of EMBASE and PUBMED was performed describing the use of NPWT in patients with SMIfollowing AWHR. Reviewed articles evaluating data about the association between clinical, demographic, analyticand surgical characteristics about SMI after AWHR were analyzed. The high heterogeneity of these studies did notallow a meta-analysis of outcomes.ResultsThe search strategy yielded 33 studies from PubMed, and 16 studies from EMBASE. NPWT was performed in 230patients across 9 studies being achieved the mesh salvage in 196 (85.2%). Of these 230 cases, 46% werepolypropylene (PPL), 9.9% polyester (PE), 16.8% polytetrafluoroethylene (PTFE), 4% biologic and 10.2%composite mesh (PPL and PTFE). Infected mesh location was onlay (43%), retromuscular (22%), preperitoneal(19%), intraperitoneal (10%) and between the oblique muscles (5%). The better option on salvageability with theuse of NPWT was the combination of macroporous PPL mesh in an extraperitoneal position (19.2% onlay, 23.3%preperitoneal, 48.8% retromuscular).ConclusionNPWT is a sufficient approach to treat SMI following AWHR. In most cases, infected prostheses can be salvagedwith this management. Further studies with a larger sample size are needed to confirm our analysis results.
C1 [Bueno-Lledo, Jose; Bonafe-Diana, Santiago; Pous-Serrano, Salvador] La Fe Hosp Univ Valencia, Dept Digest Surg, Unit Abdominal Wall Surg, Calle Gabriel Miro 28,Puerta 12, Valencia 46008, Spain.
   [Martinez-Hoed, Jesus] Hosp Rafael Angel Calderon Guardia, San Jose, Costa Rica.
RP Bueno-Lledó, J (通讯作者)，La Fe Hosp Univ Valencia, Dept Digest Surg, Unit Abdominal Wall Surg, Calle Gabriel Miro 28,Puerta 12, Valencia 46008, Spain.
EM buenolledo@hotmail.co
RI Bueno-Lledó, Jose/I-2674-2019
OI Bueno-Lledó, Jose/0000-0002-3116-5022; Pous-Serrano,
   Salvador/0000-0002-2931-0366
CR Anesäter E, 2011, INT WOUND J, V8, P336, DOI 10.1111/j.1742-481X.2011.00790.x
   Baharestani MM, 2011, INT WOUND J, V8, P118, DOI 10.1111/j.1742-481X.2010.00756.x
   Bayer, 2018, INTERVENTIONAL TREAT, P193, DOI DOI 10.1007/978-3-319-66990-8_12
   Berrevoet F, 2013, HERNIA, V17, P67, DOI 10.1007/s10029-012-0969-3
   Boettge K, 2021, ANN MED SURG, V61, P64, DOI 10.1016/j.amsu.2020.12.013
   Boullenois H, 2016, J VISC SURG, V153, P461, DOI 10.1016/j.jviscsurg.2016.09.007
   Brown RH, 2013, AM J SURG, V205, P182, DOI 10.1016/j.amjsurg.2012.02.023
   Bueno-Lledó J, 2017, AM J SURG, V214, P47, DOI 10.1016/j.amjsurg.2016.10.022
   Bueno-Lledó J, 2017, AM J SURG, V213, P50, DOI 10.1016/j.amjsurg.2016.03.007
   Gachabayov M, 2020, HERNIA, V24, P433, DOI 10.1007/s10029-019-02095-4
   Garcia-Ruano A, 2016, J SURG RES, V206, P292, DOI 10.1016/j.jss.2016.08.030
   Gillion JF, 2012, J VISC SURG, V149, pE20, DOI 10.1016/j.jviscsurg.2012.04.003
   Greenberg JJ, 2010, HERNIA, V14, P589, DOI 10.1007/s10029-010-0694-8
   Kao AM, 2018, PLAST RECONSTR SURG, V142, p149S, DOI 10.1097/PRS.0000000000004871
   Kim PJ, 2020, INT WOUND J, V17, P1194, DOI 10.1111/iwj.13424
   Meagher H, 2015, HERNIA, V19, P231, DOI 10.1007/s10029-013-1069-8
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NR 28
TC 7
Z9 10
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD JUN
PY 2023
VL 47
IS 6
BP 1495
EP 1502
DI 10.1007/s00268-023-06943-4
EA FEB 2023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AK6F8
UT WOS:000936912500003
PM 36802233
DA 2026-07-24
ER
PT J
AU Liu, CB
   Xie, HT
   Wei, P
   Gong, T
   Wu, GH
   Xu, ZR
   Chen, S
AF Liu, Canbin
   Xie, Hongteng
   Wei, Pei
   Gong, Teng
   Wu, Guohua
   Xu, Zhaorong
   Chen, Shun
TI Clinical study of early rehabilitation training combined with negative
   pressure wound therapy for the treatment of deep partial-thickness hand
   burns
SO FRONTIERS IN SURGERY
LA English
DT Article
DE hand burn; negative pressure wound therapy; total active motion; brief
   Michigan Hand Function profiles; early rehabilitation training
ID EARLY MOBILIZATION PROTOCOL; MANAGEMENT; INJURIES; MOBILITY; IMPACT; ICU
AB ObjectiveThis study aims to explore the clinical effect of early rehabilitation training combined with negative pressure wound therapy (NPWT) for treating deep partial-thickness hand burns. MethodsTwenty patients with deep partial-thickness hand burns were randomly divided into an experimental group (n = 10) and a control group (n = 10). In the experimental group, early rehabilitation training combined with NPWT was performed, including the proper sealing of the negative pressure device, intraoperative plastic brace, early postoperative exercise therapy during negative pressure treatment, and intraoperative and postoperative body positioning. Routine NPWT was conducted in the control group. Both groups received 4 weeks of rehabilitation after wounds healed by NPWT with or without skin grafts. Hand function was evaluated after wound healing and 4 weeks after rehabilitation, including hand joint total active motion (TAM) and the brief Michigan Hand Questionnaire (bMHQ). ResultsTwenty patients were involved in this study, including 16 men and 4 women, aged 18-70 years, and the hand burn area ranged from 0.5% to 2% of the total body surface area (TBSA). There was no significant difference in TAM and bMHQ scores between the two groups after negative pressure removal. After 4 weeks of rehabilitation training, the TAM scores and bMHQ scores were significantly improved in both groups (p < 0.05); among them, those of the experimental group were both significantly better than those of the control group (p < 0.05). ConclusionThe application of early rehabilitation training combined with NPWT to treat deep partial-thickness hand burns can effectively improve hand function.
C1 [Liu, Canbin; Xie, Hongteng; Wei, Pei; Gong, Teng; Wu, Guohua; Xu, Zhaorong; Chen, Shun] Fujian Med Univ, Burn & Wound Repair Dept, Union Hosp, Fuzhou, Peoples R China.
   [Liu, Canbin; Xie, Hongteng; Wei, Pei; Gong, Teng; Wu, Guohua; Xu, Zhaorong; Chen, Shun] Fujian Med Univ, Fujian Burn Inst, Union Hosp, Fuzhou, Peoples R China.
   [Liu, Canbin; Xie, Hongteng; Wei, Pei; Gong, Teng; Wu, Guohua; Xu, Zhaorong; Chen, Shun] Fujian Med Univ, Fujian Burn Med Ctr, Union Hosp, Fuzhou, Peoples R China.
   [Liu, Canbin; Xie, Hongteng; Wei, Pei; Gong, Teng; Wu, Guohua; Xu, Zhaorong; Chen, Shun] Fujian Med Univ, Fujian Prov Key Lab Burn & Trauma, Union Hosp, Fuzhou, Peoples R China.
C3 Fujian Medical University; Fujian Medical University; Fujian Medical
   University; Fujian Medical University
RP Xu, ZR; Chen, S (通讯作者)，Fujian Med Univ, Burn & Wound Repair Dept, Union Hosp, Fuzhou, Peoples R China.; Xu, ZR; Chen, S (通讯作者)，Fujian Med Univ, Fujian Burn Inst, Union Hosp, Fuzhou, Peoples R China.; Xu, ZR; Chen, S (通讯作者)，Fujian Med Univ, Fujian Burn Med Ctr, Union Hosp, Fuzhou, Peoples R China.; Xu, ZR; Chen, S (通讯作者)，Fujian Med Univ, Fujian Prov Key Lab Burn & Trauma, Union Hosp, Fuzhou, Peoples R China.
EM fjchenshun@126.com; 234828306@qq.com
RI Gong, Teng/AIA-3355-2022
FU High-level Hospital and Clinical Specialty Discipline Construction
   Programme for Fujian Medical Development, China [[2021]76]; Fujian
   Provincial Key Laboratory of Burn and Trauma, China; National Natural
   Science Foundation of China [82002034]
FX This work was supported by the High-level Hospital and Clinical
   Specialty Discipline Construction Programme for Fujian Medical
   Development, China ([2021]76) and Fujian Provincial Key Laboratory of
   Burn and Trauma, China. This work was also supported by the National
   Natural Science Foundation of China (Grant No. 82002034).
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NR 32
TC 4
Z9 5
U1 2
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD FEB 8
PY 2023
VL 10
AR 1040407
DI 10.3389/fsurg.2023.1040407
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9G7PE
UT WOS:000938339500001
PM 36843993
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Slavkovic, M
   Zivanovic, D
   Ducic, S
   Lasic, V
   Bukvic, N
   Nikolic, H
   Martinovic, V
AF Slavkovic, Milan
   Zivanovic, Dragoljub
   Ducic, Sinisa
   Lasic, Valentina
   Bukvic, Nado
   Nikolic, Harry
   Martinovic, Vlatka
TI Comparison of Negative Pressure Wound Therapy (NPWT) and Classical Wet
   to Moist Dressing (WtM) in the Treatment of Complicated Extremity Wounds
   in Children
SO CHILDREN-BASEL
LA English
DT Article
DE negative pressure wound therapy; wet to moist dressing; complicated
   wound; pediatric population
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; INFANTS
AB Treating complicated wounds in the pediatric population using traditional wet to moist wound dressing methods is not always appropriate due to the frequent need to change dressings daily or even a number of times a day, causing distress to the patient. Topical negative pressure is a method that allows for fewer dressings and provides localized benefits, thus accelerating wound healing. The merits of this therapy have been proven in studies on adults, but research on the pediatric population is scarce. Here we intend to present the results of negative pressure wound therapy (NPWT) on 34 pediatric patients (study group) and compare them with 24 patients (control group) treated with the traditional wet to moist dressing for complicated wounds. The results show that topical negative pressure wound therapy is a safe method that downgrades a wound from a complicated to a simple one and allows definitive coverage using a simpler technique with fewer wound dressings. The scars of the patients in the study group exhibited a better result on a visual scar scale. The patients in the control group had a shorter hospital stay. Based on the recorded results, we were able to make treatment recommendations.
C1 [Slavkovic, Milan; Ducic, Sinisa] Univ Childrens Hosp, Belgrade 11000, Serbia.
   [Zivanovic, Dragoljub] Univ Nis, Fac Med, Nish 18000, Serbia.
   [Zivanovic, Dragoljub] Univ Clin Ctr Nis, Clin Pediat Surg Orthoped & Traumatol, Nish 18000, Serbia.
   [Ducic, Sinisa] Univ Belgrade, Fac Med, Belgrade 11000, Serbia.
   [Lasic, Valentina; Martinovic, Vlatka] Univ Clin Hosp Mostar, Dept Pediat Surg Clin Surg, Mostar 88000, Bosnia & Herceg.
   [Lasic, Valentina; Martinovic, Vlatka] Univ Mostar, Fac Med, Mostar 88000, Bosnia & Herceg.
   [Bukvic, Nado; Nikolic, Harry] Clin Hosp Ctr Rijeka, Dept Pediat Surg, Rijeka 51000, Croatia.
   [Bukvic, Nado; Nikolic, Harry] Univ Rijeka, Fac Med, Rijeka 51000, Croatia.
C3 University of Belgrade; University of Nis; University of Nis; University
   of Belgrade; University of Mostar; University of Mostar; University of
   Rijeka; University of Rijeka
RP Slavkovic, M (通讯作者)，Univ Childrens Hosp, Belgrade 11000, Serbia.
EM milan.slavkovic@udk.bg.ac.rs
RI Zivanovic, Dragoljub/AGI-4442-2022
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NR 24
TC 4
Z9 5
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD FEB
PY 2023
VL 10
IS 2
AR 298
DI 10.3390/children10020298
PG 15
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 9H6TC
UT WOS:000938962000001
PM 36832427
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, HY
   Wang, ZX
   Wang, JC
   Zhang, XD
AF Li, He-Yun
   Wang, Zhi-Xiang
   Wang, Jian-Chun
   Zhang, Xiao-Di
TI Clostridium perfringens gas gangrene caused by closed
   abdominal injury: A case report and review of the literature
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Review
DE Clostridium perfringens; Intra-abdominal infection; Gas gangrene; Open
   abdomen; Case report
AB BACKGROUNDAbdominal Clostridium perfringens (C. perfringens) gas gangrene is a rare infection that has been described in the literature as most frequently occurring in postoperative patients with open trauma. Intra-abdominal gas gangrene caused by C. perfringens infection after closed abdominal injury is extremely rare, difficult to diagnose, and progresses rapidly with high mortality risk. Here, we report a case of C. perfringens infection caused by closed abdominal injury.CASE SUMMARYA 54-year-old male suffered multiple intestinal tears and necrosis after sustaining an injury caused by falling from a high height. These injuries and the subsequent necrosis resulted in intra-abdominal C. perfringens infection. In the first operation, we removed the necrotic intestinal segment, kept the abdomen open and covered the intestine with a Bogota bag. A vacuum sealing drainage system was used to cover the outer layer of the Bogota bag, and the drainage was flushed under negative pressure. The patient was transferred to the intensive care unit for supportive care and empirical antibiotic treatment. The antibiotics were not changed until the results of bacterial culture and drug susceptibility testing were obtained. Two consecutive operations were then performed due to secondary intestinal necrosis. After three definitive operations, the patient successfully survived the perioperative period. Unfortunately, he died of complications related to Guillain-Barre syndrome 75 d after the first surgery. This paper presents this case of intra-abdominal gas gangrene infection and analyzes the diagnosis and treatment based on a review of current literature.CONCLUSIONWhen the intestines rupture leading to contamination of the abdominal cavity by intestinal contents, C. perfringens bacteria normally present in the intestinal tract may proliferate in large numbers and lead to intra-abdominal infection. Prompt surgical intervention, adequate drainage, appropriate antibiotic therapy, and intensive supportive care comprise the most effective treatment strategy. If the abdominal cavity is heavily contaminated, an open abdominal approach may be a beneficial treatment.
C1 [Li, He-Yun] Shaanxi Nucl Ind 215 Hosp, Dept Intens Care Unit, Xianyang 712000, Shaanxi, Peoples R China.
   [Wang, Zhi-Xiang; Zhang, Xiao-Di] Shaanxi Nucl Ind 215 Hosp, Dept Gen Surg, Xianyang 712000, Shaanxi, Peoples R China.
   [Wang, Jian-Chun] Shaanxi Nucl Ind 215 Hosp, Dept Healthcare associate Infect Management, Xianyang 712000, Shaanxi, Peoples R China.
   [Zhang, Xiao-Di] Shaanxi Nucl Ind 215 Hosp, Dept Gen Surg, Xianyang 712000, Shaanxi, Peoples R China.
RP Zhang, XD (通讯作者)，Shaanxi Nucl Ind 215 Hosp, Dept Gen Surg, Xianyang 712000, Shaanxi, Peoples R China.
EM zhangxd215@163.com
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NR 34
TC 2
Z9 3
U1 1
U2 5
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD FEB 6
PY 2023
VL 11
IS 4
BP 852
EP 858
DI 10.12998/wjcc.v11.i4.852
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9J4QV
UT WOS:000940174200013
PM 36818624
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Xing, WQ
   Yang, Y
   Bai, Y
   Yu, XC
   Chang, ZQ
AF Xing, Wenqiang
   Yang, Yang
   Bai, Yun
   Yu, Xiuchun
   Chang, Zhengqi
TI A Comparison of Negative Pressure and Conventional Therapy in Spine
   Infections: A Single-Center Retrospective Study
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE spondylodiscitis; clinical outcome; negative pressure wound
   therapy(NPWT); spinal infection
ID BACTERIAL BIOFILM; WOUND THERAPY; MANAGEMENT; TUBERCULOSIS; SURGERY;
   BIOPSY; YIELD
AB Purpose: To investigate the effectiveness and safety of negative-pressure wound therapy (NPWT) in treating primary spinal infections. Methods: Patients who underwent surgical treatment for primary spinal infection between January 2018 and June 2021 were retrospectively evaluated. They were divided into two groups based on the type of surgery: one that underwent negative-pressure wound therapy (NPWT) and another that underwent conventional surgery (CVSG-Posterior debridement, bone grafting, fusion, and internal fixation in one stage). The two groups were compared in terms of the total operation time, total blood loss, total postoperative drainage, postoperative pain score, time for the postoperative erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) to return to normal, postoperative complications, treatment time, and recurrence rate. Results: A total of 43 cases of spinal infection were evaluated, with 19 in the NPWT group and 24 in the CVSG group. The NPWT group had a superior postoperative drainage volume, antibiotic use time, erythrocyte sedimentation rate and CRP recovery times, VAS score at 3 months after the operation, and cure rate at 3 months after operation compared with the CVSG group. There were no significant variations in the total hospital stay and intraoperative blood loss between the two groups. Conclusions: This study supports the use of negative pressure in the treatment of a primary spinal infection and indicates that it has a notably better short-term clinical effect than conventional surgery. Additionally, its mid-term cure rate and recurrence rate are more desirable than those of conventional treatments.
C1 [Xing, Wenqiang; Yang, Yang; Bai, Yun; Yu, Xiuchun; Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Jinan 250031, Peoples R China.
   [Bai, Yun] 80th Grp Army Hosp PLA, Dept Orthoped, Weifang 261000, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Jinan 250031, Peoples R China.
EM changzq960@163.com
RI ; Xing, Wenqiang/MBW-3134-2025
OI chang, zhengqi/0000-0001-6490-2239; 
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NR 23
TC 10
Z9 10
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD FEB
PY 2023
VL 13
IS 2
AR 162
DI 10.3390/jpm13020162
PG 8
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA 9J8HF
UT WOS:000940420100001
PM 36836397
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Huang, XH
   Zheng, LQ
   Dai, YX
   Hu, SN
   Ning, WC
   Li, SM
   Fan, YG
   Lin, ZL
   Huang, SH
AF Huang, Xiu-Hong
   Zheng, Li-Qin
   Dai, Yue-Xing
   Hu, Shao-Nan
   Ning, Wan-Chen
   Li, Si-Min
   Fan, Yue-Guang
   Lin, Zi-Ling
   Huang, Shao-Hong
TI Combined computational analysis and cytology show limited depth
   osteogenic effect on bone defects in negative pressure wound therapy
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Article
DE negative pressure wound therapy (NPWT); computational fluid dynamics;
   CFD; bone marrow; bone mesenchymal stem cells (BMSCs); genes sequence;
   bone regeneration
ID MESENCHYMAL STEM-CELLS; VACUUM-ASSISTED CLOSURE; SHEAR-STRESS; MARROW;
   MANAGEMENT; DIFFERENTIATION; FRACTURES; MECHANISM; STIFFNESS; TRAUMA
AB Background: The treatment of bone defects remains a clinical challenge. The effect of negative pressure wound therapy (NPWT) on osteogenesis in bone defects has been recognized; however, bone marrow fluid dynamics under negative pressure (NP) remain unknown. In this study, we aimed to examine the marrow fluid mechanics within trabeculae by computational fluid dynamics (CFD), and to verify osteogenic gene expression, osteogenic differentiation to investigate the osteogenic depth under NP.Methods: The human femoral head is scanned using micro-CT to segment the volume of interest (VOI) trabeculae. The VOI trabeculae CFD model simulating the bone marrow cavity is developed by combining the Hypermesh and ANSYS software. The effect of trabecular anisotropy is investigated, and bone regeneration effects are simulated under NP scales of -80, -120, -160, and -200 mmHg. The working distance (WD) is proposed to describe the suction depth of the NP. Finally, gene sequence analysis, cytological experiments including bone mesenchymal stem cells (BMSCs) proliferation and osteogenic differentiation are conducted after the BMSCs are cultured under the same NP scale.Results: The pressure, shear stress on trabeculae, and marrow fluid velocity decrease exponentially with an increase in WD. The hydromechanics of fluid at any WD inside the marrow cavity can be theoretically quantified. The NP scale significantly affects the fluid properties, especially those fluid close to the NP source; however, the effect of the NP scale become marginal as WD deepens. Anisotropy of trabecular structure coupled with the anisotropic hydrodynamic behavior of bone marrow; An NP of -120 mmHg demonstrates the majority of bone formation-related genes, as well as the most effective proliferation and osteogenic differentiation of BMSCs compared to the other NP scales.Conclusion: An NP of -120 mmHg may have the optimal activated ability to promote osteogenesis, but the effective WD may be limited to a certain depth. These findings help improve the understanding of fluid mechanisms behind NPWT in treating bone defects.
C1 [Huang, Xiu-Hong; Hu, Shao-Nan; Ning, Wan-Chen; Li, Si-Min; Huang, Shao-Hong] Southern Med Univ, Stomatol Hosp, Sch Stomatol, Guangzhou, Peoples R China.
   [Zheng, Li-Qin; Dai, Yue-Xing] Guangzhou Univ Chinese Med, Clin Med Coll 1, Guangzhou, Peoples R China.
   [Fan, Yue-Guang] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Joint Surg, Guangzhou, Peoples R China.
   [Lin, Zi-Ling] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Orthoped Trauma, Guangzhou, Peoples R China.
C3 Southern Medical University - China; Guangzhou University of Chinese
   Medicine; Guangzhou University of Chinese Medicine; Guangzhou University
   of Chinese Medicine
RP Huang, SH (通讯作者)，Southern Med Univ, Stomatol Hosp, Sch Stomatol, Guangzhou, Peoples R China.; Lin, ZL (通讯作者)，Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Orthoped Trauma, Guangzhou, Peoples R China.
EM 13600460045@sina.cn; hsh.china@tom.com
RI ; Ning, Wanchen/AAW-8866-2021; /Q-1923-2015; 胡, 少南/CAH-9613-2022
OI Zheng, Liqin/0000-0002-8157-5433; Ning, Wanchen/0000-0003-1075-997X;
   huang, xiuhong/0000-0002-8788-3314; 
FU Science Research Cultivation Program of Stomatological Hospital,
   Southern Medical University [PY2022004]; National Famous Old Chinese
   Medicine Expert Inheritance Studio Construction Project; National
   Natural Science Foundation of China [81673996]
FX Science Research Cultivation Program of Stomatological Hospital,
   Southern Medical University (PY2022004); National Famous Old Chinese
   Medicine Expert Inheritance Studio Construction Project (2022); National
   Natural Science Foundation of China (81673996).
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U1 2
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD FEB 16
PY 2023
VL 11
AR 1056707
DI 10.3389/fbioe.2023.1056707
PG 18
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 9M8MT
UT WOS:000942477400001
PM 36873351
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Askey, T
   Major, D
   Arnold, C
AF Askey, Tianti
   Major, Dustin
   Arnold, Carolyn
TI Negative pressure wound therapy for the management of surgical site
   infections with zoonotic, drug-resistant pathogens on the upper body of
   the horse
SO EQUINE VETERINARY EDUCATION
LA English
DT Article
DE horse; contaminated wounds; NPWT; surgical site infection;
   vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE
AB This case series reviews the use of negative pressure wound therapy (NPWT) for surgical site infections (SSI) on the upper body of six horses at an academic referral institution between 2016 and 2020. The SSIs consisted of three ventral midline celiotomy incisions post-abdominal exploratory, one paralumbar flank incision for removal of an ovarian abscess, an incision for resection of a septic jugular vein, and a large defect resulting from the resection of chronically abscessed skin and subcutaneous tissue on the shoulder and pectoral region. All SSIs contained zoonotic, polymicrobial, multi-drug resistant pathogens (methicillin-resistant Staphylococcus aureus or extended spectrum beta-lactamase Klebsiella or Enterobacteriaceae) that were managed without systemic, regional, or topical antimicrobials. All horses were discharged from the hospital, and long-term follow-up revealed satisfactory functional and cosmetic outcomes according to owner questionnaires. Duration of NPWT ranged from 4 to 15 days in five horses, but one horse required NPWT for 70 days due to the large nature of the defect. The NPWT system was easy to use, well-tolerated by patients, and produced acceptable functional and cosmetic outcomes for the clients. By containing wound exudate and reducing daily wound care, it improved hospital biosecurity and reduced exposure to hospital personnel.
C1 [Askey, Tianti] One Thirteen Equine, Millsap, TX USA.
   [Major, Dustin] Texas A&M Univ, Sch Vet Med & Biomed Sci, Dept Large Anim Clin Sci, College Stn, TX 77843 USA.
   [Arnold, Carolyn] Texas Tech Univ, Sch Vet Med, Amarillo, TX USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   Tech University System; Texas Tech University
RP Major, D (通讯作者)，Texas A&M Univ, Sch Vet Med & Biomed Sci, Dept Large Anim Clin Sci, College Stn, TX 77843 USA.
EM dmajor@cvm.tamu.edu
RI Major, Dustin/OEP-0578-2025
OI Major, Dustin/0000-0002-3722-3799; Arnold, Carolyn/0000-0003-2354-5903
CR Alvarez PS, 2018, ANN MED SURG, V36, P246, DOI 10.1016/j.amsu.2018.10.007
   Elce Y.A., 2018, EQUINE VET EDUC, V32, P12
   Florczyk A, 2017, J EQUINE VET SCI, V55, P9, DOI 10.1016/j.jevs.2017.01.005
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   Haspeslagh M, 2022, EQUINE VET J, V54, P592, DOI 10.1111/evj.13487
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   Perry KL, 2015, BMC VET RES, V11, DOI 10.1186/s12917-015-0593-4
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   Rijkenhuizen ABM, 2005, PFERDEHEILKUNDE, V21, P413, DOI 10.21836/PEM20050503
   Stanley BJ, 2017, VET CLIN N AM-SMALL, V47, P1203, DOI 10.1016/j.cvsm.2017.06.006
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NR 18
TC 4
Z9 5
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0957-7734
EI 2042-3292
J9 EQUINE VET EDUC
JI Equine Vet. Educ.
PD AUG
PY 2023
VL 35
IS 8
BP E531
EP E536
DI 10.1111/eve.13789
EA MAR 2023
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA L4GM7
UT WOS:000943994300001
OA hybrid
DA 2026-07-24
ER
PT J
AU Kim, KE
   Jeong, JY
   Park, TJ
   Kim, IH
AF Kim, Ko Eun
   Jeong, Jae Yeong
   Park, Tae Jun
   Kim, Il-Hwan
TI A Case of Malignant Transformation of Solitary Recurrent Cylindroma on
   Scalp
SO ANNALS OF DERMATOLOGY
LA English
DT Article
DE Adenoid cystic carcinoam; Malignant adenoid cystic carcinoma; Mohs
   surgery; Negative-pressure wound therapy
ID PRESSURE WOUND THERAPY
AB A 78-year-old male presented with an asymptomatic pinkish multi-nodular mass on his frontal scalp. The lesion had recurred twice after incomplete surgical excision. Initial punch biopsy was diagnosed with cylindroma. He revisited after one year with exophytic enlargement of the mass, and two staged Mohs micrographic surgery identified well-differentiated malignant cylindroma. Histopathology in the lower dermis and periosteal layer showed atypical cells with mitosis and hyperchromatic nucleoli with increased Ki-67 index of 10% to 30%. The postoperative wound was successfully treated with negative wound pressure therapy (NPWT) and secondary intentional healing. We report this case showing malignant transformation of solitary cylindroma, and good result for secondary intention healing using NPWT for postoperative defect.
C1 [Kim, Ko Eun; Jeong, Jae Yeong; Park, Tae Jun; Kim, Il-Hwan] Korea Univ, Dept Dermatol, Ansan Hosp, 123 Jeokgeum Ro, Ansan 15355, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Kim, IH (通讯作者)，Korea Univ, Dept Dermatol, Ansan Hosp, 123 Jeokgeum Ro, Ansan 15355, South Korea.
EM kumcihk@korea.ac.kr
RI ; Kim, Ko Eun/AER-3267-2022
OI JEONG, JAEYEONG/0000-0003-0272-3563; Park, Tae Jun/0000-0001-7610-7670;
   Kim, Ko Eun/0000-0002-4141-204X; Kim, Il-Hwan/0000-0002-4225-002X
CR Bansal Cherry, 2012, Indian J Dermatol, V57, P141, DOI 10.4103/0019-5154.94289
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   Pereira S, 2017, J SURG CASE REP, DOI 10.1093/jscr/rjx122
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NR 10
TC 2
Z9 2
U1 0
U2 1
PU KOREAN DERMATOLOGICAL ASSOC
PI SEOUL
PA 305 SEOCHO NASAN, SUITE OFFICE 1330-16, SEOCHO-2-DONG, SEOCHO-GU, SEOUL,
   137-858, SOUTH KOREA
SN 1013-9087
EI 2005-3894
J9 ANN DERMATOL
JI Ann. Dermatol.
PD DEC
PY 2022
VL 34
IS 6
BP 478
EP 481
DI 10.5021/ad.20.118
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 9Q1SN
UT WOS:000944751900010
PM 36478431
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Luo, RZ
   Liang, Y
   Yang, JR
   Feng, HQ
   Chen, Y
   Jiang, XP
   Zhang, Z
   Liu, J
   Bai, Y
   Xue, JT
   Chao, SY
   Xi, Y
   Liu, XQ
   Wang, EG
   Luo, D
   Li, Z
   Zhang, JP
AF Luo, Ruizeng
   Liang, Yi
   Yang, Jinrui
   Feng, Hongqing
   Chen, Ying
   Jiang, Xupin
   Zhang, Ze
   Liu, Jie
   Bai, Yuan
   Xue, Jiangtao
   Chao, Shengyu
   Xi, Yi
   Liu, Xiaoqiang
   Wang, Engui
   Luo, Dan
   Li, Zhou
   Zhang, Jiaping
TI Reshaping the Endogenous Electric Field to Boost Wound Repair via
   Electrogenerative Dressing
SO ADVANCED MATERIALS
LA English
DT Article
DE electric field therapy; epithelial regeneration; negative-pressure wound
   therapy; self-powered electrical simulation dressings; triboelectric
   nanogenerators
ID NEGATIVE-PRESSURE; COLLAGEN; LIFE
AB The endogenous electric field (EF) generated by transepithelial potential difference plays a decisive role in wound reepithelialization. For patients with large or chronic wounds, negative-pressure wound therapy (NPWT) is the most effective clinical method in inflammation control by continuously removing the necrotic tissues or infected substances, thus creating a proproliferative microenvironment beneficial for wound reepithelialization. However, continuous negative-pressure drainage causes electrolyte loss and weakens the endogenous EF, which in turn hinders wound reepithelialization. Here, an electrogenerative dressing (EGD) is developed by integrating triboelectric nanogenerators with NPWT. By converting the negative-pressure-induced mechanical deformation into electricity, EGD produces a stable and high-safety EF that can trigger a robust epithelial electrotactic response and drive the macrophages toward a reparative M2 phenotype in vitro. Translational medicine studies confirm that EGD completely reshapes the wound EF weakened by NPWT, and promotes wound closure by facilitating an earlier transition of inflammation/proliferation and guiding epithelial migration and proliferation to accelerate reepithelialization. Long-term EGD therapy remarkably advances tissue remodeling with mature epithelium, orderly extracellular matrix, and less scar formation. Compared with the golden standard of NPWT, EGD orchestrates all the essential wound stages in a noninvasive manner, presenting an excellent prospect in clinical wound therapy.
C1 [Luo, Ruizeng; Liang, Yi; Yang, Jinrui; Chen, Ying; Jiang, Xupin; Zhang, Ze; Liu, Jie; Liu, Xiaoqiang; Zhang, Jiaping] Third Mil Med Univ, Army Med Univ, Southwest Hosp, State Key Lab Trauma Burns & Combined Injury,Dept, Chongqing 400038, Peoples R China.
   [Luo, Ruizeng; Feng, Hongqing; Bai, Yuan; Xue, Jiangtao; Chao, Shengyu; Wang, Engui; Luo, Dan; Li, Zhou] Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 101400, Peoples R China.
   [Luo, Ruizeng; Feng, Hongqing; Chao, Shengyu; Luo, Dan; Li, Zhou] Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China.
   [Liang, Yi] Army 73rd Grp Mil Hosp, Dept Burn & Plast Surg, Xiamen 361000, Peoples R China.
   [Bai, Yuan; Luo, Dan; Li, Zhou] Guangxi Univ, Ctr Nanoenergy Res, Sch Phys Sci & Technol, Nanning 530004, Peoples R China.
   [Xue, Jiangtao] Beijing Inst Technol, Inst Engn Med, Beijing 100081, Peoples R China.
   [Xi, Yi] Chongqing Univ, Dept Appl Phys, Chongqing Key Lab Soft Condensed Matter Phys & Sma, State Key Lab Power Transmiss Equipment & Syst Sec, Chongqing 400044, Peoples R China.
   [Li, Zhou] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China.
C3 Army Medical University; Chinese Academy of Sciences; Beijing Institute
   of Nanoenergy & Nanosystems, CAS; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS; Guangxi University;
   Beijing Institute of Technology; Chongqing University; Chinese Academy
   of Sciences
RP Zhang, JP (通讯作者)，Third Mil Med Univ, Army Med Univ, Southwest Hosp, State Key Lab Trauma Burns & Combined Injury,Dept, Chongqing 400038, Peoples R China.; Luo, D; Li, Z (通讯作者)，Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 101400, Peoples R China.; Luo, D; Li, Z (通讯作者)，Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China.; Luo, D; Li, Z (通讯作者)，Guangxi Univ, Ctr Nanoenergy Res, Sch Phys Sci & Technol, Nanning 530004, Peoples R China.; Li, Z (通讯作者)，Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China.
EM luodan@binn.cas.cn; zli@binn.cas.cn; japzhang@aliyun.com
RI Liang, Yi/GLS-2479-2022; Yang, Jinrui/HGE-7359-2022; Xue,
   Jiangtao/OSI-0256-2025; bai, yuan/HDM-6641-2022; Li, Zhou/E-7734-2018;
   Feng, Hongqing/I-5222-2019
OI Xue, Jiangtao/0009-0002-3459-3513; Wang, Engui/0009-0005-6983-3929;
   Feng, Hongqing/0000-0003-2767-3080; 杨, 杨谨瑞/0000-0002-9120-6092; ,
   Jiaping/0000-0003-4034-883X
FU Strategic Priority Research Program of Chinese Academy of Sciences
   [XDA16021101]; National Natural Science Foundations of China [T2125003,
   81873936, 61875015, 51902344, 81971770]; Clinical Technology Innovation
   and Cultivation Project of Army Medical University [CX2019JS102];
   Beijing Natural Science Foundation [JQ20038, L212010]; National Key
   Research and Development Program of China [2021YFB3201200,
   2022YFB3200192]; Chongqing Natural Science Foundation
   [cstc2019jscxmsxmX0101]; outstanding project of the Youth training
   Program of Military Medical Science and Technology [21QNPY026]
FX R.L., Y.L., and J.Y. contributed equally to this work. The authors are
   grateful to all the laboratory members for their cooperation in this
   study. The authors thank Prof. Jianda Dong of the Ningxia Medical
   University for his help in the analysis of H&E staining. The authors are
   grateful for the support received from the Strategic Priority Research
   Program of Chinese Academy of Sciences (Grant No. XDA16021101), the
   National Natural Science Foundations of China (Grant Nos. T2125003,
   81873936, 61875015, 51902344, and 81971770), the Clinical Technology
   Innovation and Cultivation Project of Army Medical University (Grant No.
   CX2019JS102), the Beijing Natural Science Foundation (Grant Nos. JQ20038
   and L212010), the National Key Research and Development Program of China
   (Grant Nos. 2021YFB3201200, 2022YFB3200192), the Chongqing Natural
   Science Foundation (Grant No. cstc2019jscxmsxmX0101), and the
   outstanding project of the Youth training Program of Military Medical
   Science and Technology (Grant No. 21QNPY026). The authors thank Henan
   Huibo Medical Co., Ltd. for their technical support.
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NR 46
TC 186
Z9 191
U1 31
U2 399
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0935-9648
EI 1521-4095
J9 ADV MATER
JI Adv. Mater.
PD APR
PY 2023
VL 35
IS 16
DI 10.1002/adma.202208395
EA MAR 2023
PG 15
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
   Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
   Physics, Condensed Matter
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA E4TV8
UT WOS:000946164200001
PM 36681867
HC Y
HP N
DA 2026-07-24
ER
PT J
AU Fan, CW
   Chen, PH
   Jhou, HJ
   Cheng, YC
AF Fan, Cheng-Wei
   Chen, Po-Huang
   Jhou, Hong-Jie
   Cheng, Yi-Chiao
TI Negative pressure wound management in perineal wound status post
   abdominoperineal resection and extralevator abdominoperineal excision: a
   meta-analysis and trial sequential analysis
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Negative pressure wound therapy; Abdominoperineal resection and
   extralevator abdominoperineal excision
ID CROHNS-DISEASE; RECTAL-CANCER; THERAPY
AB Purpose Recent evidence-based publications disclosed that negative pressure wound therapy (NPWT) may reduce the incidence rate of surgical site infection (SSI) and length of stay (LOS) compared with conventional drainage in patient status post abdominoperineal resection (APR) and extralevator abdominoperineal excision (ELAPE). Methods Data sources: Eligible randomized controlled trials and retrospective and prospective studies published before January 2023 were retrieved from databases (Cochrane Library, PubMed, and Embase). Study selection: (a) The study involved patients undergoing ELAPE or APR with postoperative NPWT; (b) the study compared NWPT with conventional drainage and reported at least one outcome of interest (i.e., SSI); and (c) the study provided adequate information to calculate the effect estimated for meta-analysis. Interventions: We calculated the odds ratio (ORs) and mean differences (MDs) with 95% confidence intervals (CIs). Main outcome measures: The measure outcomes included surgical site infection(SSI) and length of stay (LOS). Results Eight articles, involving 547 patients, met the selection criteria. Compared to conventional drainage, NPWT was associated with a significantly lower SSI rate (fixed effect, OR 0.29; 95% CI 0.18-0.45; I-2 = 0%) in eight studies and 547 patients. Besides, NPWT was associated with a shorter LOS (fixed effect, MD - 2.00; CI - 2.60 to - 1.39; I-2 = 0%) than conventional drainage in three studies and 305 patients. In a trial sequential analysis, the cumulative number of patients in the analyses of both outcomes exceeded the required information size and surpassed the significance boundary in favor of NPWT, suggesting conclusive results. Conclusion NPWT is superior to conventional drainage in both SSI rate and LOS, and the statistical power of SSI and LOS are confirmed by trial sequential analysis.
C1 [Fan, Cheng-Wei] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Surg, Taipei, Taiwan.
   [Chen, Po-Huang] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Taipei, Taiwan.
   [Jhou, Hong-Jie] Changhua Christian Hosp, Dept Neurol, Changhua, Taiwan.
   [Cheng, Yi-Chiao] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Surg, Div Colon & Rectal Surg, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical University;
   National Defense Medical University; Tri-Service General Hospital;
   Changhua Christian Hospital; Tri-Service General Hospital; National
   Defense Medical University
RP Chen, PH (通讯作者)，Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Taipei, Taiwan.; Cheng, YC (通讯作者)，Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Surg, Div Colon & Rectal Surg, Taipei, Taiwan.
EM chenpohuang@hotmail.com; ndmcjoe@gmail.com
RI Jhou, Hong-Jie/AAP-9636-2020; Chen, Po-Huang/AAX-2927-2021; Cheng,
   Yi-Chiao/HPD-1659-2023
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NR 34
TC 3
Z9 4
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD MAR 18
PY 2023
VL 38
IS 1
AR 73
DI 10.1007/s00384-023-04353-5
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 9X2KW
UT WOS:000949602600001
PM 36933148
DA 2026-07-24
ER
PT J
AU Wen, YW
   Wang, CH
   Jia, HT
   Liu, T
   Yu, JZ
   Zhang, MY
AF Wen, Yuwei
   Wang, Chunhua
   Jia, Haiting
   Liu, Tao
   Yu, Jiazhi
   Zhang, Mengyuan
TI Comparison of diagnosis and treatment of MSSA and MRSA osteomyelitis in
   children: a case-control study of 64 patients
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Osteomyelitis; Methicillin-resistant Staphylococcus aureus; Drug
   resistance; Microbial; Child
ID ACUTE HEMATOGENOUS OSTEOMYELITIS; PEDIATRIC MUSCULOSKELETAL INFECTION;
   RESISTANT STAPHYLOCOCCUS-AUREUS; METHICILLIN-RESISTANT
AB BackgroundWe aimed to compare the clinical characteristics of acute osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) in children.MethodsWe retrospectively analyzed the data of 64 children treated between September 2017 and June 2021. Based on the bacterial culture results, they were divided into MRSA and MSSA infection groups. Both groups were treated with debridement and vacuum-assisted closure for negative pressure drainage. Parameters including clinical manifestations, number of operations, length of hospital stay, inflammatory indicators, and concurrent arthritis were compared between the two groups.ResultsIn the MRSA infection group, there was one case each of residual joint stiffness and pathological fracture. Conversely, the MSSA group had two cases of residual joint stiffness. The MRSA infection group was more prone to high fever (t = 3.61, P = 0.001), white blood cell count elevation (t = 2.41, P = 0.022), arthritis (X-2 = 7.48, P = 0.013), metastatic abscess (X-2 = 4.78, P = 0.042), and a shorter length of progression from onset to admission (t = - 2.04, P = 0.046); however, it required more surgeries (t = 2.68, P = 0.009) and longer hospital stay (t = 2.04, P = 0.045).ConclusionsPediatric acute osteomyelitis caused by MRSA is more prone to cause high fever and markedly elevated of white blood cell count, and is often accompanied with suppurative infection of adjacent joints and metastatic abscesses, thus requiring more surgeries and longer hospital stay.
C1 [Wen, Yuwei] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Orthopaed, 56 Nalishi Rd, Beijing 100045, Peoples R China.
   [Wang, Chunhua; Jia, Haiting; Liu, Tao; Yu, Jiazhi] Shandong Univ, Childrens Hosp, Jinan Childrens Hosp, Dept Orthopaed Trauma Surg, 23976 Jingshi Rd, Jinan 250022, Shandong, Peoples R China.
   [Zhang, Mengyuan] Dept Peking Union Med Coll, Class 2025, Beijing 100730, Peoples R China.
C3 Capital Medical University; Shandong University
RP Wang, CH (通讯作者)，Shandong Univ, Childrens Hosp, Jinan Childrens Hosp, Dept Orthopaed Trauma Surg, 23976 Jingshi Rd, Jinan 250022, Shandong, Peoples R China.
EM wchxewk@126.com
FU National Key R&D Program of China [2020YFC1107604] Funding Source:
   Medline
CR Al Jalaf M, 2018, BMC EMERG MED, V18, DOI 10.1186/s12873-018-0164-7
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NR 24
TC 8
Z9 11
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD MAR 13
PY 2023
VL 18
IS 1
AR 197
DI 10.1186/s13018-023-03670-3
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 9X5KZ
UT WOS:000949810000006
PM 36915118
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Collinsworth, AW
   Griffin, LP
AF Collinsworth, Ashley W.
   Griffin, Leah P.
TI The Effect of Timing of Instillation Therapy on Outcomes and Costs for
   Patients Receiving Negative Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time; wound
   cleansing; wound treatment
ID VACUUM-ASSISTED CLOSURE; CARE; STANDARD; HEALTH; IMPACT; TRIAL
AB Introduction. Although NPWTi-d has been associated with improved patient outcomes compared with NPWT alone, questions remain regarding the timing of NPWTi-d initiation. Objective. This study examined the effect of the timing of NPWTi-d initiation on patient outcomes and costs. Methods. A retrospective analysis was conducted utilizing a national, all-payer hospital database and included patients who received NPWTi-d in 2019. A matched cohort of 514 patients who received either early (within 1 day of NPWT application) or late (within 2-7 days of NPWT application) NPWTi-d initiation was created using propensity scoring. Differences in clinical outcomes and costs were compared using Wilcoxon rank sum, chi-square, and t tests. Results. Early NPWTi-d initiation was associated with significantly shorter NPWT duration (7.0 vs. 11.4 days; P <.0001) and inpatient stay (13.4 vs. 16.3 days; P <.0001) compared with late NPWTi-d initiation. Early NPWTi-d initiation was also associated with fewer debridements, OR visits during hospitalization, days until final OR procedure, and wound-related readmissions. Patients with early NPWTi-d initiation had a $10 877 lower mean cost of index admission (P <.0001), which included lower NPWT costs. Conclusion. Study data suggest that in these patients with wounds, early NPWTi-d initiation helped improve patient outcomes and reduced care costs
C1 [Collinsworth, Ashley W.; Griffin, Leah P.] 3M, St Paul, MN USA.
   [Collinsworth, Ashley W.] 12930 W Interstate 10, San Antonio, TX 78249 USA.
C3 3M
RP Collinsworth, AW (通讯作者)，12930 W Interstate 10, San Antonio, TX 78249 USA.
EM acollinsworth@mmm.com
CR Anchalia Manjulata, 2020, Wounds, V32, pE84
   [Anonymous], 2020, PREM HEALTHC DAT DAT
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   Yang C, 2017, WOUNDS, V29, P240
NR 24
TC 11
Z9 11
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2022
VL 34
IS 11
BP 269
EP +
DI 10.25270/wnds/22013
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 9X6BA
UT WOS:000949851700005
PM 36322918
DA 2026-07-24
ER
PT J
AU Boti, L
   Soloway, L
   Myers, D
   Pillai, D
   Zabihi, J
AF Boti, Leila
   Soloway, Laura
   Myers, Deb
   Pillai, Dinu
   Zabihi, Javad
TI Decreased Health Care Expenditure and Average Length of Therapy With
   Facilitated Transition Discharge Program for Patients Receiving Negative
   Pressure Wound Therapy br
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article; Proceedings Paper
CT Joint Annual Meeting of the Wound-Healing-Society (WHS) / Spring
   Symposium on Advanced Wound Care (SAWC)
CY APR 06-10, 2022
CL ELECTR NETWORK
SP Wound Healing Soc
DE discharge programs; hospital stays; negative pressure wound therapy
AB This study compares LOT between patients discharged from hospitals with FT discharge programs providing NPWT to patients at/before discharge versus those without (non-FT). FT facilities were further segmented: active-FT (>= 1 transition order during past 90 days) versus inactive-FT (FT set up but no orders during past 90 days). There were 82 543 billable orders and 92 008 patients analyzed. LOT was 1.8 days shorter for FT versus non-FT facilities (potential per-patient savings of $5071 for FT facilities). LOT was 1.2 days shorter in active-FT versus inactive-FT facilities. This study shows shorter stays and LOT for patients in facilities actively using FT.
C1 [Boti, Leila; Soloway, Laura; Myers, Deb; Pillai, Dinu; Zabihi, Javad] 3M Hlth Care, St Paul, MN USA.
   [Boti, Leila] 7703 Cypress View, Boerne, TX 78015 USA.
C3 3M
RP Boti, L (通讯作者)，7703 Cypress View, Boerne, TX 78015 USA.
EM lboti@mmm.com
CR Baek H, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0195901
   HCUP Reports. Healthcare Cost and Utilization Project (HCUP), 2017, HCUP REPORTS
   Lagoe RJ, 2021, Case Reports in Clinical Medicine, V10, P160, DOI [10.4236/crcm.2021.106020, 10.4236/crcm.2021.106020, DOI 10.4236/CRCM.2021.106020]
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   Thorup CB, 2018, INT WOUND J, V15, P707, DOI 10.1111/iwj.12913
NR 6
TC 1
Z9 1
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2022
VL 34
IS 12
BP E118
EP E120
DI 10.25270/wnds/22050
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Dermatology; Surgery
GA A0QV4
UT WOS:000952271300002
PM 36645656
DA 2026-07-24
ER
PT J
AU Shehata, MSA
   Bahbah, E
   El-Ayman, Y
   Abdelkarim, AH
   Abdalla, AR
   Morshedy, A
   Turkmani, K
   Seth, I
   Seth, N
AF Shehata, Mohamed S. A.
   Bahbah, Eshak
   El-Ayman, Yousef
   Abdelkarim, Ahmed H.
   Abdalla, Ahmed R.
   Morshedy, Ahmed
   Turkmani, Khaled
   Seth, Ishith
   Seth, Nimish
TI Effectiveness of Negative Pressure Wound Therapy in Patients With
   Challenging Wounds:A Systematic Review and Meta-analysis br
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE meta-analysis; negative pressure wound therapy; vacuum-assisted wound
   closure; wound healing
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; TRIAL; MULTICENTER; INFECTION;
   ULCERS; IMPACT; CARE
AB Introduction. Controversy exists regarding the use of NPWT for wound healing. Objective. This study assessed the effectiveness of NPWT compared with conventional treatment in the management of different wound types, including acute and chronic wounds. Materials and Methods. PubMed, Cochrane Central Register of Controlled Trials, Scopus, EMBASE, EBSCO, Ovid, and Web of Science were searched, from database inception up to October 2021, for relevant studies comparing NPWT with conventional treatment for wound healing. Primary outcomes included time to healing, wound healing rate, and duration of treatment. Secondary outcomes included adverse events, length of hospital stay, and 30-day mortality rate. Pooled analysis of the outcomes data is presented as SMD (95% CI) for continuous data and OR (95% CI) for dichotomous data. Results. Twenty-four studies (3064 patients) were included in the meta-analysis. NPWT was associated with shorter time to healing (SMD, -0.79; 95% CI, -1.22 to -0.37), shorter duration of treatment (SMD, -1.24; 95% CI, -1.92 to -0.56), and higher rate of wound healing (OR, 2.05; 95% CI, 1.49-2.83) compared with control. NPWT was also associated with a lower incidence of adverse events (OR, 0.42; 95% CI, 0.23-0.77) and a lower 30-day mortality rate (OR, 0.25; 95% CI, 0.12-0.56). There were no significant differences between NPWT and control regarding hospital stay (SMD, -0.52; 95% CI, -1.06 to 0.03). Conclusions. NPWT is seemingly associated with better wound healing outcomes compared with conventional therapy. However, the data should be interpreted with substantial caution given limitations such as high heterogeneity between studies and the small sample size of the included studies.
C1 [Shehata, Mohamed S. A.; El-Ayman, Yousef; Abdelkarim, Ahmed H.] Zagazig Univ, Fac Med, Zagazig, Egypt.
   [Shehata, Mohamed S. A.] Nasr City Insurance Hosp, Cairo, Egypt.
   [Bahbah, Eshak] Al Azhar Univ, Fac Med, Dumyat, Egypt.
   [Abdalla, Ahmed R.] Mansoura Univ, Fac Med, Mansoura, Egypt.
   [Morshedy, Ahmed] Kafrelsheikh Univ, Fac Med, Kafrelsheikh, Egypt.
   [Turkmani, Khaled] Damascus Univ, Fac Med, Damascus, Syria.
   [Seth, Ishith] Illawarra Shoalhaven Local Hlth Dist, Wollongong, Australia.
   [Seth, Nimish] Alfred Hosp, Dept Orthopaed, Melbourne, Australia.
   [Shehata, Mohamed S. A.] Nasr City Insurance Hosp, Cairo 44771, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Al Azhar University; Egyptian Knowledge Bank (EKB); Mansoura
   University; Egyptian Knowledge Bank (EKB); Kafrelsheikh University;
   Damascus University; Illawarra Shoalhaven Local Health District; Florey
   Institute of Neuroscience & Mental Health; Howard Florey Institute
   Affiliates
RP Shehata, MSA (通讯作者)，Nasr City Insurance Hosp, Cairo 44771, Egypt.
EM mohamed.shehata6@outlook.com
RI ; El-Ayman, Yousef/ACI-3730-2022; Bahbah, Eshak/I-4504-2019; Abdelkarim,
   Ahmed/MAH-4449-2025; /S-9752-2017; Shehata, Mohamed/J-2933-2014
OI Shehata, Mohamed S.A/0000-0001-9580-4279; El-Ayman,
   Yousef/0000-0003-0711-4257; Bahbah, Eshak/0000-0002-6168-9134;
   Abdelkarim, Ahmed/0000-0002-6514-0077; 
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   Thompson JT, 2007, CLIN PLAST SURG, V34, P673, DOI 10.1016/j.cps.2007.07.005
   Tuncel U, 2013, INT WOUND J, V10, P152, DOI 10.1111/j.1742-481X.2012.00955.x
   Vos RJ, 2012, INTERACT CARDIOV TH, V14, P17, DOI 10.1093/icvts/ivr049
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
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NR 53
TC 12
Z9 12
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2022
VL 34
IS 12
BP E126
EP E134
DI 10.25270/wnds/21061
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA A0QV4
UT WOS:000952271300004
PM 36645658
DA 2026-07-24
ER
PT J
AU James, CV
   Murray, Q
   Park, SY
   Khajoueinejad, N
   Lee, JN
   Ray, K
   Lantis, JCL
AF James, Crystal V.
   Murray, Quinn
   Park, So Youn
   Khajoueinejad, Nazanin
   Lee, Jani
   Ray, Keval
   Lantis II, John C.
TI Venous Leg Ulcers: Potential Algorithms of Care br
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE cellular- and tissue-based therapy; fetal bovine dermis; negative
   pressure wound therapy; pentoxifylline; physical therapy; veins; venous
   leg ulcer
ID PRESSURE WOUND THERAPY; DERMAL MATRIX; SKIN-GRAFTS; MANAGEMENT;
   ULCERATION; CLOSURE; COMPRESSION; REFLUX
AB Management of VLUs can be challenging, depending on wound complexity, and may require the use of several treatment modalities to achieve complete wound closure or significant wound area reduction. This review presents a systematic approach to management of VLUs based on previous literature and the authors' clinical experience, with consideration given to wound size, etiology, and responses to prior treatment. Techniques described include debridement (autolytic, enzymatic, sharp/surgical), compression therapy, physical therapy, medical adjuncts, and cellular- and tissue-based therapy. The algorithm of care for VLUs is multimodal. Appropriate diagnostic studies must be performed, including venous duplex and appropriate pathophysiology to confirm the diagnosis of VLU. After the correct diagnosis is confirmed, appropriate treatment may commence. All patients should undergo appropriate wound debridement; the exact modality used is dependent on wound characteristics. Patients must also adhere to consistent compression therapy. Any underlying venous disease that is amenable to surgical intervention should be addressed. Treatment with a medical adjunct and physical therapy are recommended. For patients who do not achieve significant wound area reduction, the addition of CTP is recommended. Use of these methods should result in substantial wound area reduction and/or wound closure.
C1 [James, Crystal V.; Murray, Quinn; Lantis II, John C.] Mount Sinai West Morningside Hosp, Dept Surg, New York, NY USA.
   [Park, So Youn; Khajoueinejad, Nazanin; Lee, Jani; Ray, Keval] Mt Sinai Hosp, Dept Surg, New York, NY USA.
   [James, Crystal V.] Mount Sinai West Med Ctr, 1000 10th Ave, New York, NY 10019 USA.
C3 Icahn School of Medicine at Mount Sinai
RP James, CV (通讯作者)，Mount Sinai West Med Ctr, 1000 10th Ave, New York, NY 10019 USA.
EM Crystal.James2@mountsinai.org
CR AmnioExcel, INTEGRA
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NR 58
TC 5
Z9 8
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2022
VL 34
IS 12
BP 288
EP 296
DI 10.25270/wnds/21160
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA A0QV4
UT WOS:000952271300010
PM 36622379
DA 2026-07-24
ER
PT J
AU Betz, V
   van Ackeren, V
   Scharsack, E
   Stark, B
   Mueller, CT
   Loske, G
AF Betz, V.
   van Ackeren, V.
   Scharsack, E.
   Stark, B.
   Mueller, C. T.
   Loske, G.
TI Intrathoracic negative pressure therapy for pleural empyema using an
   open-pore drainage film
SO CHIRURGIE
LA English
DT Article
DE Bacterial infection; Thoracotomy; Drainage; Lung; Video-assisted
   thoracic surgery
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; PERFORATION
AB BackgroundWe report our initial experience with intrathoracic negative pressure therapy (ITNPT) in the stage-adjusted treatment of pleural empyema (PE) based on a case series.Materials and methodsITNPT represents a further development for intrathoracic use. After thoracic surgical open debridement, an intrathoracic negative pressure dressing was inserted. The drainage elements were a thin open-pore double-layer drainage film (OF) with open-pore polyurethane foams (PUF). Only the OF was placed in direct contact with the lung parenchyma. Negative pressure was generated using an electronic pump (continuous suction, -75 mm Hg). In revision thoracotomies, ITNPT was stopped or continued depending on local findings.ResultsIn total, 31 patients with stage II and III pleural empyema underwent ITNPT, which was administered during the primary procedure (n = 17) or at revision (n = 14). Treatment duration was a mean of 10 days (2-18 days) with a mean change interval of 4 days (2-6 days). Intrathoracic negative pressure dressings were applied a mean of 3.5 (1-6) times. The empyema cavity continuously reduced in size and was cleansed by the suction. The OF has a minimum intrinsic volume with maximum absorption surface. Once negative pressure is established, there is no intrathoracic dead volume and the parenchyma can expand. The protective material properties of OF make ITNPT suitable for the treatment of pleural empyema. Targeted local intrathoracic drainage of the septic focus is a possible adjunct to surgery. The surgical dressings must be changed repeatedly. The method is suitable for the treatment of complex stage II and III pleural empyemas.ConclusionThe OF can be used as an intrathoracic drainage element for ITNPT in pleural empyema. This new application option expands the range of indications for negative pressure therapy.
C1 [Betz, V.; van Ackeren, V.; Scharsack, E.; Stark, B.; Mueller, C. T.; Loske, G.] Marienkrankenhaus Kathol Marienkrankenhaus GmbH, Hamburg, Germany.
RP Betz, V (通讯作者)，Marienkrankenhaus Kathol Marienkrankenhaus GmbH, Hamburg, Germany.
EM viktoria.betz@web.de
CR Adams O, S2K LEITLINIE MANAGE
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NR 30
TC 1
Z9 1
U1 1
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2731-6971
EI 2731-698X
J9 CHIRURGIE
JI Chirurgie
PD JUN
PY 2023
VL 94
IS 6
SI SI
BP 530
EP 543
DI 10.1007/s00104-023-01827-8
EA MAR 2023
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA H1YG5
UT WOS:000952463600001
PM 36920498
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Mehkri, Y
   Sharaf, R
   Tishad, A
   Gendreau, J
   Hernandez, J
   Panther, E
   Pafford, R
   Rahmathulla, G
AF Mehkri, Yusuf
   Sharaf, Ramy
   Tishad, Abtahi
   Gendreau, Julian
   Hernandez, Jairo
   Panther, Eric
   Pafford, Ryan
   Rahmathulla, Gazanfar
TI Cost Savings Associated with Vacuum-Assisted Closure in Trauma Patients
   Undergoing Posterior Spinal Fusion
SO WORLD NEUROSURGERY
LA English
DT Article
DE Cost analysis; Minimally invasive; Negative pressure; Open; Posterior
   spinal fusion; Trauma; Wound vacuum
ID SURGICAL SITE INFECTION; CARE-ASSOCIATED INFECTIONS; PRESSURE WOUND
   THERAPY; IMPACT; PREVENTION; GUIDELINE; MORTALITY; OUTCOMES; RISK
AB -OBJECTIVE: To investigate the implications of vacuum -assisted closure (VAC) versus standard wound dressings on postoperative posterior spinal fusion (PSF) wounds with respect to potential cost savings associated with reduced incidence of surgical site infections. -METHODS: This was a retrospective review of trauma patients who underwent open PSF under the care of a single surgeon at a Level I trauma center. Patients were postoperatively monitored for 90 days. Statistical analysis was performed with c2 testing with the calculation of -umber needed to treat values.-RESULTS: Inclusion criteria were met by 208 patients who underwent open PSF. The c2 test revealed a significant increase in incidence of surgical site infections (20% vs. 8%; P = 0.021) in the non-VAC group (n = 112) compared with the VAC group (n = 96). Cost-benefit analysis revealed that use of VAC in patients undergoing open PSF could enable a mean cost savings of $163,492 per 100 patients. -CONCLUSIONS: Use of VAC in patients undergoing open PSF was associated with a 2-fold decrease in incidence of surgical site infections and an infection-related cost sav-ings of $163,492 per 100 patients. Further investigation is needed to ascertain additional benefits of VAC usage in patients undergoing open PSF.
C1 [Mehkri, Yusuf; Sharaf, Ramy; Tishad, Abtahi; Hernandez, Jairo; Panther, Eric; Pafford, Ryan; Rahmathulla, Gazanfar] Univ Florida, Dept Neurosurg, Coll Med, Jacksonville, FL 32611 USA.
   [Gendreau, Julian] Johns Hopkins Whiting Sch Engn, Dept Biomed Engn, Baltimore, MD USA.
   [Rahmathulla, Gazanfar] Mayo Clin Hlth Syst, Dept Neurosurg, Eau Claire, WI 55905 USA.
C3 State University System of Florida; University of Florida; Johns Hopkins
   University
RP Rahmathulla, G (通讯作者)，Univ Florida, Dept Neurosurg, Coll Med, Jacksonville, FL 32611 USA.; Rahmathulla, G (通讯作者)，Mayo Clin Hlth Syst, Dept Neurosurg, Eau Claire, WI 55905 USA.
EM rahmathulla.gazanfar@mayo.edu
RI ; Rahmathulla FACS FCNS MBA, Gazanfar/D-1890-2014; Rahmathulla,
   Gazanfar/D-1890-2014
OI Sharaf, Ramy/0000-0001-9942-3852; Geneau, Julian/0000-0001-8412-0437;
   Rahmathulla FACS FCNS MBA, Gazanfar/0000-0002-0904-1840; 
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NR 30
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD MAR
PY 2023
VL 171
BP E147
EP E152
DI 10.1016/j.wneu.2022.11.103
EA FEB 2023
PG 6
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA A0YC7
UT WOS:000952464800001
PM 36442776
DA 2026-07-24
ER
PT J
AU Bueno-Lledó, J
   Rubio-Pérez, I
   Moreno-Gijón, M
   Olona-Casas, C
   Barbosa, E
   Molina, JM
   Castellanos, G
AF Bueno-Lledo, Jose
   Rubio-Perez, Ines
   Moreno-Gijon, Maria
   Olona-Casas, Carles
   Barbosa, Eva
   Molina, Jose Manuel
   Castellanos, Gregorio
TI Prophylactic use of incisional negative pressure wound therapy for the
   prevention of surgical site occurrences in general surgery: Consensus
   document
SO SURGERY
LA English
DT Article
ID INCREASES RISK; HERNIA REPAIR; INFECTIONS; ASSOCIATION; LAPAROTOMY;
   IMPACT; TRIAL; AGE
AB Background: Surgical site occurrences pose a threat to patient health, potentially resulting in significant increases in health care spending caused by using additional resources. The objective of this study was to reach a consensus among a group of experts in incisional negative pressure wound therapy to determine the indications for using this type of treatment prophylactically and to analyze the associated risk factors of surgical site occurrences in abdominal surgery.Methods: A group of experts in incisional negative pressure wound therapy from Spain and Portugal was formed among general surgery specialists who frequently perform colorectal, esophagogastric, or abdominal wall surgery. The Coordinating Committee performed a bibliographic search to identify the most relevant publications and to create a summary table to serve as a decision-making protocol regarding the use of prophylactic incisional negative pressure wound therapy based on factors related to the patient and type of procedure. Results: The patient risk factors associated with surgical site occurrence development such as age, immunosuppression, anticoagulation, hypoalbuminemia, smoking, American Society of Anesthesiolo-gists classification, diabetes, obesity, and malnutrition were analyzed. For surgical procedure factors, surgical time, repeated surgeries, organ transplantation, need for blood transfusion, complex abdominal wall reconstruction, surgery at a contaminated site, open abdomen closure, emergency surgery, and hyperthermic intraperitoneal chemotherapy were analyzed.Conclusion: In our experience, this consensus has been achieved on a tailored set of recommendations on patient and surgical aspects that should be considered to reduce the risk of surgical site occurrences with the use of prophylactic incisional negative pressure wound therapy, particularly in areas where the evidence base is controversial or lacking.(c) 2022 Elsevier Inc. All rights reserved.
C1 [Bueno-Lledo, Jose] Univ Valencia, Hosp Univ & Politecn La Fe, Dept Digest Surg, Unit Abdominal Wall Reconstruct, Valencia, Spain.
   [Rubio-Perez, Ines] Hosp Univ La Paz, Dept Gen Surg, Unit Colorectal Surg, Madrid, Spain.
   [Moreno-Gijon, Maria] Hosp Univ Cent Asturias, Dept Digest Surg, Unit Esophagogastr Bariatr & Abdominal Wall Surg, Oviedo, Spain.
   [Olona-Casas, Carles] Hosp Univ Tarragona Joan XXIII, Inst Invest Sanitaria Pere Virgili, Dept Gen & Digest Surg, Unit Esophagogastr & Abdominal Wall Surg, Tarragona, Spain.
   [Barbosa, Eva] Univ Porto, Ctr Hosp Univ Sao Joao, Dept Gen Surg, Unit Complex Abdominal Wall Reconstruct, Porto, Portugal.
   [Molina, Jose Manuel] Univ Alcala de Henares, Hosp Univ Ramon & Cajal, Dept Gen & Digest Surg, Complex Abdominal Wall Reconstruct Hepatobiliary, Madrid, Spain.
   [Castellanos, Gregorio] Univ Murcia, Hosp Clin Univ Virgen de la Arrixaca, Dept Surg, Murcia, Spain.
C3 University of Valencia; Hospital Universitari i Politecnic La Fe;
   Hospital Universitario La Paz; Central University Hospital Asturias;
   Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Hospital Universitari De Tarragona Joan XXIII;
   Universidade do Porto; Hospital Universitario Ramon y Cajal; Universidad
   de Alcala; University of Murcia; Hospital Clinico Universitario Virgen
   de la Arrixaca
RP Bueno-Lledó, J (通讯作者)，Calle Gabriel Miro 28 Puerta 12, Valencia 46008, Spain.
EM buenolledo@hotmail.com
RI ; Bueno-Lledó, Jose/I-2674-2019
OI Moreno Gijón, María/0000-0003-2328-9874; Bueno-Lledó,
   Jose/0000-0002-3116-5022
FU Smith Nephew
FX All authors have been speakers for Smith & Nephew and had grants with
   Smith & Nephew (workshops) .
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NR 49
TC 6
Z9 7
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD APR
PY 2023
VL 173
IS 4
BP 1052
EP 1059
DI 10.1016/j.surg.2022.11.033
EA MAR 2023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A4QT0
UT WOS:000954995200001
PM 36588049
DA 2026-07-24
ER
PT J
AU Maier, J
   Kandulski, A
   Donlon, NE
   Werner, JM
   Mehrl, A
   Mueller, M
   Doenecke, A
   Schlitt, HJ
   Hornung, M
   Weiss, ARR
AF Maier, Jonas
   Kandulski, A.
   Donlon, N. E.
   Werner, J. M.
   Mehrl, A.
   Mueller, M.
   Doenecke, A.
   Schlitt, H. J.
   Hornung, M.
   Weiss, A. R. R.
TI Endoscopic vacuum therapy significantly improves clinical outcomes of
   anastomotic leakages after 2-stage, 3-stage, and transhiatal
   esophagectomies
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Endoscopic vacuum therapy; Anastomotic leak; Esophagectomy; Gastric tube
   reconstruction; Endoscopic vacuum-assisted closure therapy; Negative
   pressure wound therapy
ID ASSISTED CLOSURE; TREATMENT OPTIONS; ESOPHAGEAL; STENT
AB BackgroundAnastomotic leakages after esophagectomies continue to constitute significant morbidity and mortality. Intrathoracic anastomoses pose a high risk for mediastinitis, sepsis, and death, if a leak is not addressed timely and appropriately. However, there are no standardized treatment recommendations or algorithms as for how to treat these leakages.MethodsThe study included all patients at the University Hospital Regensburg, who developed an anastomotic leakage after esophagectomy with gastric pull-up reconstruction from 2007 to 2022. Patients receiving conventional treatment options for an anastomotic leakage (stents, drainage tubes, clips, etc.) were compared to patients receiving endoscopic vacuum-assisted closure (eVAC) therapy as their mainstay of treatment. Treatment failure was defined as cervical esophagostomy formation or death.ResultsIn total, 37 patients developed an anastomotic leakage after esophagectomy with a gastric pull-up reconstruction. Twenty patients were included into the non-eVAC cohort, whereas 17 patients were treated with eVAC. Treatment failure was observed in 50% of patients (n = 10) in the non-eVAC cohort and in 6% of patients (n = 1) in the eVAC cohort (p < 0.05). The 90-day mortality in the non-eVAC cohort was 15% (n = 3) compared to 6% (n = 1) in the eVAC cohort. Cervical esophagostomy formation was required in 40% of cases (n = 8) in the non-eVAC cohort, whereas no patient in the eVAC cohort underwent cervical esophagostomy formation.ConclusioneVAC therapy for leaking esophagogastric anastomoses appears to be superior to other treatment strategies as it significantly reduces morbidity and mortality. Therefore, we suggest eVAC as an essential component in the treatment algorithm for anastomotic leakages following esophagectomies, especially in patients with intrathoracic anastomoses.
C1 [Maier, Jonas; Werner, J. M.; Doenecke, A.; Schlitt, H. J.; Hornung, M.; Weiss, A. R. R.] Univ Hosp Regensburg, Dept Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
   [Kandulski, A.; Mehrl, A.; Mueller, M.] Univ Hosp Regensburg, Dept Internal Med 1, Gastroenterol Hepatol Endocrinol Rheumatol & Infec, Regensburg, Germany.
   [Donlon, N. E.] Mater Misericordiae Univ Hosp, Dept Surg, Dublin, Ireland.
C3 University of Regensburg; University of Regensburg; Mater Misericordiae
   University Hospital; University College Dublin
RP Weiss, ARR (通讯作者)，Univ Hosp Regensburg, Dept Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
EM andi-weiss@outlook.com
RI Weiss, Andreas Robert Rudolf/PIH-6367-2026; Schlitt, Hans/ABG-4368-2020
OI Weiss, Andreas Robert Rudolf/0000-0003-1257-5517; 
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL. This research
   received no specific grant from any funding agency in the public,
   commercial, or not-for-profit sectors.
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
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NR 32
TC 8
Z9 8
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD FEB 15
PY 2023
VL 408
IS 1
AR 90
DI 10.1007/s00423-023-02826-3
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A5XT0
UT WOS:000955856700002
PM 36790506
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Xu, BH
   Song, X
   Weng, YJ
AF Xu, Beihua
   Song, Xia
   Weng, Yajuan
TI A Multidisciplinary Team Approach for Diabetic Foot Ulcer: A Case Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE diabetic foot ulcer; education; interprofessional; local wound care;
   multidisciplinary; negative-pressure wound therapy
ID MANAGEMENT
AB A multidisciplinary team (MDT) approach is the most efficient way to treat many chronic and serious diseases. In this case report, providers sought to implement an MDT approach to treat a patient with diabetes and foot ulcers, actively involving the patient's caregiving family members. Comprehensive evaluation, blood sugar control, and timely referral were established as the primary treatment course. Negative-pressure wound therapy was applied to completely remove necrotic tissue debris and seropurulent discharge from the foot ulcers under the consultation of the MDT team. Local wound management, protection of the periwound skin, and health education for the patient's wound care nurse specialists were integral to the treatment outcome. After 3 months of treatment, the patient's right foot wound bed was improved, and further skin-grafting surgery was performed to accelerate the healing process during follow-up treatments.
C1 [Xu, Beihua; Song, Xia] Wound Care Clin, Affiliated Hosp Soochow 3, Changzhou, Peoples R China.
   [Weng, Yajuan] Nanjing Drum Tower Hosp, Chair Wound Ostomy Continence Nursing Grp, Nanjing, Peoples R China.
C3 Nanjing University
RP Xu, BH (通讯作者)，Wound Care Clin, Affiliated Hosp Soochow 3, Changzhou, Peoples R China.
CR Armstrong David G, 2011, J Diabetes Sci Technol, V5, P1591
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NR 14
TC 9
Z9 10
U1 4
U2 45
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD APR
PY 2023
VL 36
IS 4
BP 6
EP 6
DI 10.1097/01.ASW.0000920512.88426.90
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA A6KE5
UT WOS:000956182300004
PM 36940382
DA 2026-07-24
ER
PT J
AU Lopez-Lopez, V
   Hiciano-Guillermo, A
   Martinez-Alarcon, L
   Delegido, A
   Alconchel, F
   Pons, JA
   Fernández, JA
   Ríos, A
   Rodríguez, M
   Miura, K
   Sánchez-Bueno, F
   Robles-Campos, R
   Ramírez, P
AF Lopez-Lopez, Victor
   Hiciano-Guillermo, Alberto
   Martinez-Alarcon, Laura
   Delegido, Ana
   Alconchel, Felipe
   Pons, Jose Antonio
   Fernandez, Juan Angel
   Rios, Antonio
   Rodriguez, Manuel
   Miura, Kohei
   Sanchez-Bueno, Francisco
   Robles-Campos, Ricardo
   Ramirez, Pablo
TI Postoperative negative-pressure incision therapy after liver transplant
   (PONILITRANS study): A randomized controlled trial
SO SURGERY
LA English
DT Article
ID SURGICAL SITE INFECTIONS; QUALITY-OF-LIFE; WOUND THERAPY; SIROLIMUS;
   RECIPIENTS; IMPACT
AB Background: Postoperative complications of surgical incisions are frequent in liver transplantation. However, evidence justifying the use of incisional negative pressure wound therapy to improve surgical wound outcomes remains limited. Methods: Participating patients were randomly assigned to receive incisional negative pressure wound therapy or standard surgical dressing on the closed surgical incision of the liver transplantation. The primary endpoint was surgical site infection incidence 30 days postoperatively. The secondary endpoints included surgical site events (ie, surgical site infection, dehiscence, hematoma, and seroma) and wound quality of life. Results: Between December 2018 and September 2021, 108 patients (54 in the incisional negative pressure wound therapy group and 54 in the control group) were enrolled in this study. The incidence of surgical site infection at 30 days postoperatively was 7.4% in the treatment group and 13% in the control group (P = .34). The rate of surgical site events was similar in the treatment in the and control group (27.8% vs 29.6%, P = .83). In relation to wound quality of life, the mean score was 75.20 +/- 7.27 in the incisional negative pressure wound therapy group and 72.82 +/- 10.57 in the control group (P = .23). Conclusion: The prophylactic use of negative pressure wound therapy on primarily closed incisions did not significantly reduce incisional surgical site infection and surgical site event rates after liver trans-plantation compared with standard surgical dressings. (c) 2022 Elsevier Inc. All rights reserved.
C1 [Lopez-Lopez, Victor; Hiciano-Guillermo, Alberto; Martinez-Alarcon, Laura; Delegido, Ana; Alconchel, Felipe; Rios, Antonio; Rodriguez, Manuel; Sanchez-Bueno, Francisco; Robles-Campos, Ricardo; Ramirez, Pablo] Virgen de la Arrixaca Univ Hosp, Dept Gen & Digest Surg, IMIB Arrixaca, Murcia, Spain.
   [Lopez-Lopez, Victor; Hiciano-Guillermo, Alberto; Martinez-Alarcon, Laura; Delegido, Ana; Alconchel, Felipe; Fernandez, Juan Angel; Rios, Antonio; Rodriguez, Manuel; Sanchez-Bueno, Francisco; Robles-Campos, Ricardo; Ramirez, Pablo] Biomed Res Inst Murcia, Digest & Endocrine Surg & Transplantat Abdominal, Murcia, Spain.
   [Pons, Jose Antonio] Virgen de la Arrixaca Univ Hosp, Dept Hepatol, IMIB Arrixaca, Murcia, Spain.
   [Miura, Kohei] Niigata Univ, Div Digest & Gen Surg, Grad Sch Med & Dent Sci, Niigata, Japan.
C3 Hospital Clinico Universitario Virgen de la Arrixaca; Hospital Clinico
   Universitario Virgen de la Arrixaca; Niigata University
RP Lopez-Lopez, V (通讯作者)，Univ Hosp Virgen de la Arrixaca, Dept Gen Visceral & Transplantat Surg, Ctra Madrid Cartagena S-N, Murcia 30120, Spain.
EM victorrelopez@gmail.com
RI Rios, A/L-3870-2017; Martinez-Alarcon, Laura/D-3376-2012; Pons-Miñano,
   José Antonio/S-4644-2019; Rios, A/D-3376-2012; Alconchel,
   Felipe/Q-8398-2019
OI Rios, A/0000-0001-5512-9010; Martinez-Alarcon,
   Laura/0000-0001-7497-6709; Pons-Miñano, José
   Antonio/0000-0001-5017-7240; Rios, A/0000-0001-5512-9010; Alconchel,
   Felipe/0000-0002-5483-0312; Delegido García, Ana/0000-0003-1759-4151
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   Limongelli P, 2017, INT WOUND J, V14, P960, DOI 10.1111/iwj.12739
   Lozano-Platonoff A, 2020, INT WOUND J, V17, P167, DOI 10.1111/iwj.13253
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   Mangram AJ, 1999, AM J INFECT CONTROL, V27, P97, DOI 10.1016/S0196-6553(99)70088-X
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   National Institute for Health and Care Excellence, 2019, PREV INC MAN SYST CL
   National Institute for Health and Care Excellence, 2019, PICO negative pressure wound dressings for closed surgical incisions
   Norman G, 2020, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD009261.pub6, 10.1002/14651858.CD009261.pub5]
   Oliveira RA, 2018, AM J INFECT CONTROL, V46, P88, DOI 10.1016/j.ajic.2017.05.021
   Ousey KJ, 2014, INT WOUND J, V11, P357, DOI 10.1111/j.1742-481X.2012.01098.x
   Pellino G, 2015, UPDATES SURG, V67, P235, DOI 10.1007/s13304-015-0298-z
   Sandy-Hodgetts Kylie, 2015, JBI Database System Rev Implement Rep, V13, P253, DOI [10.11124/jbisrir-2015-1687, 10.11124/jbisrir-2015-1687]
   Saunders C., 2021, BJS Open, V5
   Scalise A, 2016, INT WOUND J, V13, P1260, DOI 10.1111/iwj.12492
   Shah H, 2014, LIVER TRANSPLANT, V20, P930, DOI 10.1002/lt.23890
   Shiroky J, 2020, SURGERY, V167, P1001, DOI 10.1016/j.surg.2020.01.018
   Singh D, 2018, PLAST RECONSTR SURG, V142, p156S, DOI 10.1097/PRS.0000000000004872
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
NR 32
TC 7
Z9 7
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD APR
PY 2023
VL 173
IS 4
BP 1072
EP 1078
DI 10.1016/j.surg.2022.11.011
EA MAR 2023
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA C4YX9
UT WOS:000961999300001
PM 36549975
DA 2026-07-24
ER
PT J
AU Gupta, S
   Srivastava, A
   Malhotra, R
   Chadha, M
   Aggarwal, AN
AF Gupta, Saurabh
   Srivastava, Amit
   Malhotra, Raskesh
   Chadha, Manish
   Aggarwal, Aditya N.
TI Wound Assessment Using Bates Jensen Wound Assessment Tool in Acute
   Musculoskeletal Injury Following Low-Cost Wall-Mounted Negative-Pressure
   Wound Therapy Application
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Negative-pressure wound therapy; Wound assessment score; Low cost; Open
   wounds; Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; ULCERS
AB BackgroundNegative-pressure wound therapy (NPWT) is an alternative method of wound management for spontaneous healing. However, availability and high cost of a conventional NPWT system remain a challenge. Bates Jensen wound assessment tool (BWAT) has been used to assess wound healing in diverse wound treatments. Although there have been studies evaluating change in BWAT score following application of commercially available NPWT device, there is no literature evaluating change in BWAT score following use of wall-mounted low-cost NPWT device.Materials and MethodsTwenty patients above the age of 18 years with acute musculoskeletal wounds who underwent surgical debridement and required subsequent wound coverage were included in the study. Wound dressings were carried out using low-cost wall-mounted negative-pressure device utilizing a constant pressure of 125 mmHg for 48 h. Wound scoring was done using the Bates Jensen wound assessment tool (BWAT). The wound scores before and after application of NPWT were compared and analyzed using Wilcoxon signed-rank test.ResultsTwenty patients fulfilling the inclusion criteria with a mean age of 37.10 +/- 14.37 were included in the study. The average BWAT score before and after NPWT application was 31.2 +/- 4.63 and 27.8 +/- 3.68, respectively. The mean reduction in total BWAT score following NPWT application was 3.4. The granulation profile improved in 90% (n = 18/20) cases with a mean reduction of 1.5 +/- 0.4 in the granulation tissue score. Exudation decreased in 60% (n = 12/20) patients with a mean reduction of 0.5 +/- 0.23 in exudation type score and 0.35 +/- 0.13 in exudation amount score. The necrotic tissue domain improved in 45% (n = 9/20) of the cases with a mean reduction of 0.45 +/- 0.31 in necrotic tissue type score and 0.20 +/- 0.12 in necrotic tissue amount score.ConclusionThere was a statistically significant reduction in the total BWAT score (p = 0.001) and an increase in granulation tissue (p = 0.001). The decrease in wound exudation (p = 0.004) and necrotic tissue coverage of the wound (p = 0.007) was also significant. However, there was no statistically significant change in wound depth, size, edges, undermining, tissue edema, tissue induration, and wound epithelialization after 48 h of continuous low-cost wall-mounted negative suction application in these patients.
C1 [Gupta, Saurabh; Srivastava, Amit; Malhotra, Raskesh; Chadha, Manish; Aggarwal, Aditya N.] Univ Coll Med Sci, Guru Teg Bahadur Hosp, Dept Orthopaed, Delhi 110095, India.
   [Srivastava, Amit] D-56 New Ashok Nagar, Delhi 110096, India.
C3 University of Delhi; University College of Medical Sciences
RP Srivastava, A (通讯作者)，Univ Coll Med Sci, Guru Teg Bahadur Hosp, Dept Orthopaed, Delhi 110095, India.; Srivastava, A (通讯作者)，D-56 New Ashok Nagar, Delhi 110096, India.
EM saurabh.14796@gmail.com; amitsrvstv00@gmail.com; malhotraucms@gmail.com;
   mchadha@hotmail.com; dranaggarwal@hotmail.com
RI /AAS-4744-2021
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Bates-Jensen B M, 1992, Decubitus, V5, P20
   Bates-Jensen BM, 2019, WOUND REPAIR REGEN, V27, P386, DOI 10.1111/wrr.12714
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   Harris C, 2010, J WOUND OSTOMY CONT, V37, P253, DOI 10.1097/WON.0b013e3181d73aab
   Huang WS, 2006, ASIAN J SURG, V29, P133
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   Litwiniuk M, 2012, MOL MED REP, V6, P723, DOI 10.3892/mmr.2012.983
   Liu ZM, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010318.pub3
   McCallon SK, 2015, WOUNDS, V27, P44
   Moore K, 1999, J Wound Care, V8, P345
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Nakayama M, 2010, INT WOUND J, V7, P160, DOI 10.1111/j.1742-481X.2010.00667.x
   Nie B, 2016, J WOUND CARE, V25, P617, DOI 10.12968/jowc.2016.25.11.617
   Pathak Siddharth, 2021, J Clin Orthop Trauma, V23, P101668, DOI [10.1016/j.jcot.2021.101668, 10.1016/j.jcot.2021.101668]
   Porso M, 2017, ULTRASOUND MED BIOL, V43, P362, DOI 10.1016/j.ultrasmedbio.2016.08.038
   Singh M, 2009, INTERNET J PLAST SUR, V6, P1
   Takahashi J, 2017, INT J CLIN EXP MED, V10, P5586
   Tao QS, 2015, J SURG RES, V198, P535, DOI 10.1016/j.jss.2015.04.004
   Yadav R, 2022, Indian Journal of Orthopaedics Surgery, V8, P49, DOI 10.18231/j.ijos.2022.008
NR 24
TC 7
Z9 8
U1 0
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD JUN
PY 2023
VL 57
IS 6
BP 948
EP 956
DI 10.1007/s43465-023-00861-2
EA APR 2023
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA G3IK8
UT WOS:000962664800001
PM 37214372
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Tuncer, GK
   Tuncer, K
   Aydogan, S
AF Tuncer, Gizem Kilinc
   Tuncer, Korhan
   Aydogan, Serdar
TI Do Stoma Formation and Use of Vacuum Assisted Closure System Affect
   Mortality in Perineal Fournier's Gangrene?
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Fournier?s gangrene; Vacuum-assisted closure system; Stoma; Anorectal
   region; Perineum; Mortality
ID MANAGEMENT
AB Objective: The aim of this study was to identify the effects of creation of stoma and the use of vacuum-assisted closure systems on postoperative mortality and hospital stay in patients with Fournier's gangrene involving anorectal region.Study Design: A retrospective study.Place and Duration of Study: Department of General Surgery, University of Health Sciences Tepecik Training and Research Hospital, Izmir, Turkey, from January 2010 to September 2021. Methodology: A total of 66 patients with Fournier's gangrene with anorectal involvement were selected from hospital records and divided into two groups as alive and exitus. Differences between these two groups and the factors affecting mortality were analysed with the SPSS statistics software, version 25.0. The value of p<0.05 was considered statistically significant.Results: The mean age of the patients was 57.9 +/- 12.9 years, however, age was higher in exitus group (p=0.013). Debridement count was significantly raised in patients with vacuum assisted closure system (p<0.001). The use of vacuum-assisted closure system was associated with a longer hospital stay (p=0.042). Both stoma creation and the use of vacuum-assisted closure system were not found as risk factors for higher mortality.Conclusion: Stoma creation and the use of vacuum-assisted closure systems have no effect on mortality in patients of Fournier's gangrene with anorectal involvement. Urogenital involvement may be considered as a risk factors for mortality.
C1 [Tuncer, Gizem Kilinc] Univ Hlth Sci, Bozyaka Training & Res Hosp, Dept Gen Surg, Izmir, Turkiye.
   [Tuncer, Korhan] Cigli Training & Res Hosp, Dept Gen Surg, Izmir, Turkiye.
   [Aydogan, Serdar] Univ Hlth Sci, Tepecik Training & Res Hosp, Dept Gen Surg, Izmir, Turkiye.
   [Tuncer, Gizem Kilinc] Bozyaka Training & Res Hosp, Dept Gen Surg, Saim Cikrikci St 56, TR-35170 Karabaglar, Turkiye.
C3 Izmir Bozyaka Training & Research Hospital; University of Health
   Sciences Turkey; University of Health Sciences Turkey; Izmir Tepecik
   Training & Research Hospital
RP Tuncer, GK (通讯作者)，Bozyaka Training & Res Hosp, Dept Gen Surg, Saim Cikrikci St 56, TR-35170 Karabaglar, Turkiye.
EM drgizemkilinc@gmail.com
RI Tuncer, Korhan/JAN-4676-2023; Kilinc Tuncer, Gizem/JXN-7091-2024
OI Kilinc Tuncer, Gizem/0000-0002-6987-3198
CR Akcan A, 2009, ULUS TRAVMA ACIL CER, V15, P342
   Carvalho Joao P., 2007, Int. braz j urol., V33, P510
   Chennamsetty A, 2015, THER ADV UROL, V7, P203, DOI 10.1177/1756287215584740
   Ersay A, 2007, ANZ J SURG, V77, P43, DOI 10.1111/j.1445-2197.2006.03975.x
   Ersoz F, 2012, SINGAP MED J, V53, P537
   Ghnnam WM, 2008, J POSTGRAD MED, V54, P106, DOI 10.4103/0022-3859.40776
   Gürdal M, 2003, UROL INT, V70, P286, DOI 10.1159/000070137
   Hong KS, 2017, INT WOUND J, V14, P1352, DOI 10.1111/iwj.12812
   김상기, 2006, [Annals of Surgical Treatment and Research, 대한외과학회지], V71, P274
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   Ozturk E, 2009, AM J SURG, V197, P660, DOI 10.1016/j.amjsurg.2008.04.018
   김광민, 2010, Annals of Coloproctolgy, V26, P29
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   WOLACH MD, 1989, BRIT J UROL, V64, P310, DOI 10.1111/j.1464-410X.1989.tb06020.x
NR 15
TC 1
Z9 3
U1 0
U2 4
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD FEB
PY 2023
VL 33
IS 2
BP 145
EP 148
DI 10.29271/jcpsp.2023.02.145
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C8XA8
UT WOS:000964672800005
PM 36797621
OA gold
DA 2026-07-24
ER
PT J
AU Sorour, AA
   Kirksey, L
   Ambur, V
   Bena, J
AF Sorour, Ahmed A.
   Kirksey, Levester
   Ambur, Vishnu
   Bena, James
TI Surgical Site Complications After Complex Iliofemoral Reconstruction and
   the Role of Negative Pressure Wound Therapy: A Retrospective,
   Single-center Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE closed incision negative pressure therapy; surgical incision; surgical
   wound; infection; femoral endarterectomy; wound healing
ID INFECTIONS; INCISION; COST
AB Introduction. Surgical site infection (SSI) of groin incisions after vascular surgery is a significant source of morbidity and is associated with high rates of readmission and reoperation, as well as longer hospital length of stay. The patient-reported health care experiences are diminished for those in whom SSI complications occur. Previous studies have analyzed patients undergoing all types of surgery requiring groin incision. The role of closed incision negative pressure therapy (CiNPT) as an adjunct to the primarily closed femoral incision after vascular surgery is unclear. Materials and Methods. This retrospective single-center study focuses on complex iliofemoral reconstruction with extensive dissection, including profundoplasty. The role of CiNPT and short-term outcomes are analyzed. Multivariable logistic regression was used to identify factors that place patients at high risk for SSI. A prediction model was performed to predict high-risk patients. Results. A total of 337 patients who underwent 422 femoral endarterectomies (85 bilateral) were included. The overall SSI rate was 16.1% (9.3% Szilagyi grade II and III), and SSI was associated with a 44% readmission rate, 38% reoperation rate, and longer mean length of stay (8.5 days vs 5.1 days; P =.02). No differences in SSI were evident between the CiNPT (n = 47) and standard dressing cohorts. The final prediction model used 5 variables: obesity (body mass index > 30), insulin use, chronic obstructive pulmonary disease (COPD), immunosuppression, and surgical duration. Conclusions. Patients with obesity, COPD, and insulin-dependent diabetes mellitus are at increased risk for SSI after femoral incisions for peripheral revascularization. A prediction model may assist in identifying patients at high risk for SSI so that targeted risk reduction strategies can be implemented to decrease morbidity and economic costs. Targeted use of CiNPT may help reduce the severity of SSI in these at-risk patients.
C1 [Sorour, Ahmed A.; Kirksey, Levester; Ambur, Vishnu; Bena, James] Cleveland Clin, Heart Vasc & Thorac Inst, Dept Vasc Surg, Cleveland, OH USA.
   [Kirksey, Levester] Cleveland Clin, Dept Vasc Surg, Cleveland, OH USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation
RP Kirksey, L (通讯作者)，Cleveland Clin, Desk H32,9500 Euclid Ave, Cleveland, OH 44195 USA.
EM kirksel@ccf.org
OI Sorour, Ahmed/0000-0002-9664-1093
CR 3M Health Care, EV BROCH EXP FDA IND
   Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
   Antoniou GA, 2019, J VASC SURG, V70, P1700, DOI 10.1016/j.jvs.2019.01.083
   Boltz MM, 2011, SURGERY, V150, P934, DOI 10.1016/j.surg.2011.04.006
   Engelhardt M, 2018, INT WOUND J, V15, P327, DOI 10.1111/iwj.12848
   Gombert A, 2018, EUR J VASC ENDOVASC, V56, P442, DOI 10.1016/j.ejvs.2018.05.018
   Gracon ASA, 2016, VASC ENDOVASC SURG, V50, P398, DOI 10.1177/1538574416666227
   Hasselmann J, 2020, ANN SURG, V271, P48, DOI 10.1097/SLA.0000000000003364
   Inui T, 2015, SEMIN VASC SURG, V28, P201, DOI 10.1053/j.semvascsurg.2016.02.002
   Kwon J, 2018, J VASC SURG, V68, P1744, DOI 10.1016/j.jvs.2018.05.224
   Lee K, 2017, J VASC SURG, V66, P1814, DOI 10.1016/j.jvs.2017.06.084
   Orr NT, 2015, J VASC SURG, V62, P1281, DOI 10.1016/j.jvs.2015.05.037
   Pleger SP, 2021, Journal of Surgery, V9, P36, DOI 10.11648/j.js.20210901.17
   Pleger SP, 2018, INT WOUND J, V15, P75, DOI 10.1111/iwj.12836
   Sabat J, 2016, J VASC SURG, V63, p94S, DOI 10.1016/j.jvs.2016.03.099
   Scalise A, 2016, INT WOUND J, V13, P1260, DOI 10.1111/iwj.12492
   Shepard J, 2013, JAMA SURG, V148, P907, DOI 10.1001/jamasurg.2013.2246
   SZILAGYI DE, 1972, ANN SURG, V176, P321, DOI 10.1097/00000658-197209000-00008
   Teixeira Gabriela, 2015, Angiol Cir Vasc, V11, P03, DOI 10.1016/j.ancv.2014.12.001
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
   Wiseman JT, 2015, J VASC SURG, V62, P1023, DOI 10.1016/j.jvs.2015.04.453
NR 21
TC 7
Z9 7
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2022
VL 34
IS 4
BP E22
EP E28
DI 10.25270/wnds/2022.e22e28
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA D0PD2
UT WOS:000965823600002
PM 35797556
DA 2026-07-24
ER
PT J
AU Matthews, MR
   Fernandez, LG
AF Matthews, Marc R.
   Fernandez, Luis G.
TI Applications of a New Silicone-acrylic Hybrid Semiocclusive Drape With
   Negative Pressure Wound Therapies in a Burn Center
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; wounds; silicone; acrylic; occlusive
   drape
AB It is essential that occlusive drapes provide both an airtight, watertight seal and prevent intrusion of the external environment into a healing wound bed. Removal of an acrylic drape, however, may result in pain, reflex erythema, and a denuding of the epidermis, including the stratum corneum. Recently, a new silicone-acrylic hybrid drape was introduced for use with negative pressure wound therapy. Five unique and varied clinical cases from a burn center that used such negative pressure wound therapy dressings with the silicone-acrylic hybrid drape are presented. These cases highlight the excellent sealing capabilities of this new occlusive drape and minimal pain upon its removal. In addition, this hybrid drape may decrease waste of dressing supply because it is easily reconfigured to its original form and can be repositioned if the initial placement is suboptimal. The drape also maintains a tight seal with repositioning, making it more user-friendly to the clinical provider.
C1 [Matthews, Marc R.] Arizona Burn Ctr, Surg, Phoenix, AZ 85008 USA.
   [Fernandez, Luis G.] Univ Texas Hlth Sci Ctr, Dept Surg, Surg, Tyler, TX USA.
   [Fernandez, Luis G.] UT Hlth East, Trauma Wound Care, Tyler, TX USA.
C3 University of Texas System; University of Texas at Tyler; University of
   Texas-Health Sciences Center at Tyler (UTHSCT)
RP Matthews, MR (通讯作者)，Arizona Burn Ctr, 2601 East Roosevelt St, Phoenix, AZ 85008 USA.
EM azmrmltc@gmail.com
CR [Anonymous], 2019, KCI ANN SIGN ADV NEG
   Ballard K, 2000, Br J Nurs, V9, P405
   Dykes P J, 2001, J Wound Care, V10, P7
   Dykes P J, 2007, J Wound Care, V16, P97
   Hollingworth H, 2009, TRAUMA PAIN WOUND CA, P87
   KCI an Acelity Company, 2019, DERMC DRAP PROD BROC
   Kilbride KE, 2006, J PEDIATR SURG, V41, P212, DOI 10.1016/j.jpedsurg.2005.10.003
   Matsumura H, 2014, INT WOUND J, V11, P50, DOI 10.1111/j.1742-481X.2012.01061.x
   Rippon MG, 2007, EUROPEAN WOUND MANAG
NR 9
TC 2
Z9 2
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2022
VL 34
IS 5
BP 141
EP 145
DI 10.25270/wnds/082421.02
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA D0PH5
UT WOS:000965827900003
PM 35839159
DA 2026-07-24
ER
PT J
AU Mancino, AT
   Acott, A
   Brinegar, KP
AF Mancino, Anne T.
   Acott, Alison
   Brinegar, Kathryn P.
TI Injection of Cryopreserved Amniotic Membrane and Umbilical Cord
   Particulate for Pressure Injuries: A Retrospective Case Series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE amniotic membrane and umbilical cord; negative pressure wound therapy;
   particulate human placental tissue; pressure injury
ID QUALITY-OF-LIFE; SINGLE-CENTER; ULCERS; APOPTOSIS; MACROPHAGES;
   NEUTROPHILS; ACTIVATION; EXPRESSION; KERATITIS; IMPACT
AB Introduction. PI poses a significant burden to society. Cryopreserved AMUC has potential benefits in managing complex wounds owing to its anti-inflammatory, anti-scarring, and proregenerative properties. AMUC grafts are commonly in sheets, but also come as morselized powders that can be sprinkled or injected. The authors initially used AMUC injection in chronic PIs in March 2017. Materials and Methods. This is a single-center, retrospective review of patients with nonhealing PIs treated with AMUC particulate between March 2017 and November 2018. Incidence of wound healing (zero wound volume with complete reepithelialization) was measured at 12, 24, 36, and 52 weeks. Results. Review included 26 PIs (21 patients); of which, 85% were stage 4 PIs, per the NPIAP staging system. After AMUC injection, 14 PIs (54%) achieved complete wound closure at a median of 12.4 weeks (range, 5-52 weeks). Complete wound closure was observed in 7 patients (27%) at 12 weeks, 10 patients (38%) at 24 weeks, 13 patients (50%) at 36 weeks, and 14 patients (54%) at 52 weeks. One patient with vascular issues required amputation; however, no treatment-related adverse events or complications were observed. Conclusions. These preliminary results suggest that injection of AMUC particulate may be a safe and promising treatment in promoting wound closure of difficult-to-treat PIs.
C1 [Mancino, Anne T.; Acott, Alison; Brinegar, Kathryn P.] Cent Arkansas Vet Healthcare Syst, Surg Serv, Little Rock, AR 72205 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System
RP Mancino, AT (通讯作者)，Cent Arkansas Vet Healthcare Syst, 4300 West 7th St, Little Rock, AR 72205 USA.
EM Anne.mancino@va.gov
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NR 46
TC 4
Z9 4
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2022
VL 34
IS 9
BP E85
EP E90
DI 10.25270/wnds/21041
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA D0QP4
UT WOS:000965861900004
PM 36252270
DA 2026-07-24
ER
PT J
AU Yu, L
   Wang, YL
   Ma, DM
   Pan, LM
   Liu, XY
   Chu, TY
   Yin, BY
   Huang, L
   Xu, X
AF Yu, Lan
   Wang, Yiling
   Ma, Dongmei
   Pan, Liming
   Liu, Xinyang
   Chu, Tianyue
   Yin, Baoyue
   Huang, Lei
   Xu, Xin
TI In-hospital nursing care intervention increasing the effect of vacuum
   sealing drainage on wound healing: A meta-analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE meta-analysis; nursing care intervention; vacuum sealing drainage; wound
   healing
AB Vacuum sealing drainage (VSD) could effectively drain superficial wounds and deep tissues, which is beneficial for wound healing. More incentives in nursing care to improve the therapeutic effect of VSD on wound healing were further investigated. Different databases were retrieved for full-text publications about the comparison between intervention nursing care and regular nursing care. Heterogeneity was detected by I-2 method, and a random-effect model was applied for data pooling if there existed heterogeneity. Publication bias was analysed by a funnel plot. Eight studies with 762 patients were included for final meta-analysis. In the nursing care intervention group, shorter hospital stay duration (pooled SMD = -2.602, 95% confidence interval: -4.052--1.151), shorter wound healing time (pooled SMD = -1.105, 95% confidence interval: -1.857--0.353), lower pain score (pooled SMD = -2.490, 95% confidence interval: -3.521--1.458), lower drainage tube blocked rate (pooled RR = 0.361, 95% confidence interval: 0.268-0.486), and higher nursing satisfaction (pooled RR = 1.164, 95% confidence interval: 1.095-1.237) was confirmed. More active and incentive nursing care could significantly improve the therapeutic effect of VSD on wound healing, in terms of hospitalisation time, wound healing time, painful symptoms, drainage tube blockage, and nursing satisfaction.
C1 [Yu, Lan; Wang, Yiling; Ma, Dongmei; Pan, Liming; Liu, Xinyang; Chu, Tianyue; Yin, Baoyue; Huang, Lei; Xu, Xin] Jilin Univ, Hand Foot Surg Nursing Platform, Hosp 1, Changchun 130021, Peoples R China.
   [Xu, Xin] Jilin Univ, Hand Foot Surg Nursing Platform, Hosp 1, 1 Xinmin St, Changchun City 130021, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Xu, X (通讯作者)，Jilin Univ, Hand Foot Surg Nursing Platform, Hosp 1, 1 Xinmin St, Changchun City 130021, Jilin, Peoples R China.
EM xxin@jlu.edu.cn
RI Ma, Dongmei/LZE-8246-2025; Pan, Liming/KLD-3038-2024; Wang,
   Yiling/PYW-2835-2026; Liu, Xinyang/PTE-6023-2026
CR Cai LY, 2022, INJURY, V53, P777, DOI 10.1016/j.injury.2021.10.018
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NR 20
TC 12
Z9 14
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2023
VL 20
IS 8
BP 3371
EP 3379
DI 10.1111/iwj.14169
EA APR 2023
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S0FS0
UT WOS:000969123300001
PM 37042301
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wu, MF
   Liu, QX
   Yu, Z
   Karvar, M
   Aoki, S
   Hamaguchi, R
   Ma, CH
   Orgill, DP
   Panayi, AC
AF Wu, Mengfan
   Liu, Qinxin
   Yu, Zhen
   Karvar, Mehran
   Aoki, Shimpo
   Hamaguchi, Ryoko
   Ma, Chenhao
   Orgill, Dennis P.
   Panayi, Adriana C.
TI Negative-Pressure Wound Therapy Induces Lymphangiogenesis in Murine
   Diabetic Wound Healing
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; LYMPHATIC-SYSTEM; FOOT ULCERS; MAST-CELLS;
   INFLAMMATION; MECHANISMS; RESOLUTION; PROTEASES; DRAINAGE
AB Background: Decreased lymphangiogenesis contributes to impaired diabetic wound healing. Although negative-pressure wound therapy (NPWT) has been shown to be effective in the treatment of recalcitrant wounds, its impact on lymphangiogenesis remains to be elucidated. In this study, the authors investigate the mechanisms of lymphangiogenesis following NPWT treatment of diabetic murine wound healing.
   Methods: Full-thickness dorsal skin wounds (1 x 1 cm(2)) were excised on 30 db/ db mice. The mice were either treated with occlusive covering (control group, n = 15), or received a 7-day treatment of continuous NPWT at -125 mmHg (NPWT group, n = 15). The wounds were photographed on days 0, 7, 10, 14, 21, and 28. Wound tissue was harvested on days 10, 14, 21, and 28 for quantitative analysis. Functional analysis of lymphatic drainage was performed on days 14 and 28 with Evans blue dye tracing.
   Results: Lymphatic density and diameter, as visualized through podoplanin probing, was significantly higher in the NPWT group compared to the control group (P < 0.001). NPWT up-regulated the expression of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) at the protein level (P = 0.04), and significant differences were noted in lymphatic density as assessed by LYVE-1 staining (P = 0.001). Leukocyte infiltration was significantly higher in the NPWT group (P = 0.01). A higher speed of wound closure (P < 0.0001) and greater wound bed thickness (P < 0.0001) were noted in the NPWT group compared to the control group.
   Conclusions: NPWT increased the lymphatic vessel density and diameter with LYVE-1 up-regulation. NPWT therefore plays a positive role in lymphangiogenesis in diabetic wound healing.
C1 [Wu, Mengfan; Liu, Qinxin; Karvar, Mehran; Aoki, Shimpo; Hamaguchi, Ryoko; Ma, Chenhao; Orgill, Dennis P.; Panayi, Adriana C.] Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA USA.
   [Wu, Mengfan; Liu, Qinxin; Karvar, Mehran; Aoki, Shimpo; Hamaguchi, Ryoko; Ma, Chenhao; Orgill, Dennis P.; Panayi, Adriana C.] Harvard Med Sch, Boston, MA 02115 USA.
   [Wu, Mengfan] Peking Univ Shenzhen Hosp, Dept Plast Surg, Shenzhen, Peoples R China.
   [Liu, Qinxin] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Traumat Surg, Wuhan, Peoples R China.
   [Yu, Zhen] Harvard Med Sch, Massachusetts Eye & Ear Infirm, Ophthalmol Dept, Angiogenesis Lab, Boston, MA 02115 USA.
   [Yu, Zhen] Jinan Univ, Shenzhen Eye Hosp, Shenzhen Key Ophthalm Lab, Guangzhou, Peoples R China.
   [Ma, Chenhao] Tsinghua Univ, Plast Surg Hosp, Peking Union Med Coll, Dept Auricular Reconstruct, Beijing, Peoples R China.
   [Ma, Chenhao] Chinese Acad Med Sci, Beijing, Peoples R China.
   [Panayi, Adriana C.] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard Medical School; Peking
   University; Huazhong University of Science & Technology; Harvard
   University; Harvard University Medical Affiliates; Massachusetts Eye &
   Ear Infirmary; Harvard Medical School; Shenzhen Eye Hospital; Jinan
   University; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Peking Union Medical College; Tsinghua University; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard Medical School
RP Panayi, AC (通讯作者)，Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM apanayi@bwh.harvard.edu
RI Orgill, Dennis/H-7596-2019; Panayi, Adriana/HHT-0513-2022; Ma,
   Chenhao/AFN-9286-2022
OI Wu, Mengfan/0000-0003-2646-3372; Panayi, Adriana/0000-0003-4053-9855;
   Yu, Zhen/0000-0003-3456-3584; 
FU Gillian Reny Stepping Strong Center for Trauma Innovation and Kinetic
   Concepts, Inc.
FX This work was funded by The Gillian Reny Stepping Strong Center for
   Trauma Innovation and Kinetic Concepts, Inc. The authors express their
   gratitude to Diane Bielenberg, PhD, for expert guidance in developing
   the lymphatic-specific immunohistochemical techniques, to George Murphy,
   MD, for generously allowing the authors' use of the laboratory facility
   and equipment in the optimization process, and to Diana Wang, MD, for
   assistance in advising the optimization.
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NR 56
TC 15
Z9 18
U1 2
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR
PY 2023
VL 151
IS 4
BP 779
EP 790
DI 10.1097/PRS.0000000000009997
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA D7CH7
UT WOS:000970264400042
PM 36729939
DA 2026-07-24
ER
PT J
AU Yuan, K
   Quah, A
   Hwee, J
   Xu, R
   Wu, YJ
   Wen, NH
   Han, PC
AF Yuan, Kong
   Quah, Alison
   Hwee, Jolie
   Xu, Roland
   Wu Yijun
   Wen, Ng Hui
   Han, Pek Chong
TI Use of negative pressure wound therapy on locoregional flaps: a
   case-control study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE flap reconstruction; incisional negative pressure wound therapy;
   locoregional flaps; negative pressure wound therapy; NPWT; perforator
   flap; reconstructive surgery; wound; wound care; wound dressing; wound
   healing
ID VACUUM-ASSISTED CLOSURE; MAJOR MUSCLE FLAP; LOWER-EXTREMITY;
   COMPLICATIONS; EXPERIENCES; SAFETY
AB Objective: The use of negative pressure wound therapy (NPWT) is ubiquitous in the management of complex wounds. Extending beyond the traditional utility of NPWT, it has been used after reconstructive flap surgery in a few case series. The authors sought to investigate the outcomes of NPWT use on flap reconstruction in a case-control study.
   Method: Patients who underwent flap reconstruction between November 2017 and January 2020 were reviewed for inclusion in the study, and divided into an NPWT group and a control group. For patients in the NPWT group, NPWT was used directly over the locoregional flap immediately post-surgery for 4-7 days, before switching to conventional dressings. The control group used conventional dressing materials immediately post-surgery. Outcome measures such as flap necrosis, surgical site infections (SSIs), wound dehiscence as well as time to full functional recovery and hospitalisation duration were evaluated.
   Results: Of the 138 patients who underwent flap reconstruction, 37 who had free flap reconstructions were excluded, and 101 patients were included and divided into two groups: 51 patients in the NPWT group and 50 patients in the control group. Both groups had similar patient demographics, and patient and wound risk factors for impaired wound healing. Results showed that there was no statistically significant difference between flap necrosis, SSIs, wound dehiscence, hospitalisation duration as well as functional recovery rates. Cost analysis showed that the use of NPWT over flaps for the first seven postoperative days may potentially be more cost effective in our setting.
   Conclusion: In this study, the appropriate use of NPWT over flaps was safe and efficacious in the immediate postoperative setting, and was not inferior to the conventional dressings used for reconstructive flap surgery. The main benefits of NPWT over flaps include better exudate management, oedema reduction and potential cost savings. Further studies would be required to ascertain any further benefit.
C1 [Yuan, Kong; Quah, Alison; Hwee, Jolie; Xu, Roland; Wu Yijun; Han, Pek Chong] Khoo Teck Puat Hosp, Dept Surg, Plast Reconstruct & Aesthet Surg Serv, Singapore, Singapore.
   [Wen, Ng Hui] Tan Tock Seng Hosiptal, Dept Gen Surg, Plast Reconstruct & Aesthet Surg Serv, Singapore, Singapore.
RP Han, PC (通讯作者)，Khoo Teck Puat Hosp, Dept Surg, Plast Reconstruct & Aesthet Surg Serv, Singapore, Singapore.
EM pekch@rocketmail.com
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NR 35
TC 5
Z9 6
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2023
VL 32
SU 4
BP S5
EP S13
DI 10.12968/jowc.2023.32.Sup4.S5
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA D7FB4
UT WOS:000970336500002
PM 37029982
DA 2026-07-24
ER
PT J
AU Heo, Y
   Kim, DH
AF Heo, Yoonjung
   Kim, Dong Hun
TI The temporary abdominal closure techniques used for trauma patients: a
   systematic review and meta-analysis
SO ANNALS OF SURGICAL TREATMENT AND RESEARCH
LA English
DT Review
DE Abdominal injuries; Laparotomy; Negative-pressure wound therapy; Open
   abdomen techniques; Wound and injuries
ID DAMAGE-CONTROL LAPAROTOMY; ASSISTED FASCIAL CLOSURE; OPEN ABDOMEN; WOUND
   CLOSURE; PERITONEAL RESUSCITATION; ABBREVIATED LAPAROTOMY; COMPARTMENT
   SYNDROME; VENTRAL HERNIA; WALL CLOSURE; MANAGEMENT
AB Purpose: The choice of temporary abdominal closure (TAC) method affects the prognosis of trauma patients. Previous studies on TAC are challenging to extrapolate due to data heterogeneity. We aimed to conduct a systematic review and comparison of various TAC techniques. Methods: We accessed web-based databases for studies on the clinical outcomes of TAC techniques. Recognized techniques, including negative-pressure wound therapy with or without continuous fascial traction, skin tension, meshes, Bogota bags, and Wittman patches, were classified via a method of closure such as skin-only closure vs. patch closure vs. vacuum closure; and via dynamics of treatment like static therapy (ST) vs. dynamic therapy (DT). Study endpoints included in-hospital mortality, definitive fascial closure (DFC) rate, and incidence of intraabdominal complications. Results: Among 1,065 identified studies, 37 papers comprising 2,582 trauma patients met the inclusion criteria. The vacuum closure group showed the lowest mortality (13%; 95% confidence interval [CI], 6%-19%) and a moderate DFC rate (74%; 95% CI, 67%-82%). The skin-only closure group showed the highest mortality (35%; 95% CI, 7%-63%) and the highest DFC rate (96%; 95% CI, 93%-99%). In the second group analysis, DT showed better outcomes than ST for all endpoints. Conclusion: Vacuum closure was favorable in terms of in-hospital mortality, ventral hernia, and peritoneal abscess. Skinonly closure might be an alternative TAC method in carefully selected groups. DT may provide the best results; however, further studies are needed.
C1 [Heo, Yoonjung] Dankook Univ, Grad Sch, Dept Med, Cheonan, South Korea.
   [Heo, Yoonjung] Dankook Univ Hosp, Trauma Ctr, Dept Trauma Surg, Cheonan, South Korea.
   [Kim, Dong Hun] Dankook Univ, Coll Med, Dept Surg, Div Trauma Surg, Cheonan, South Korea.
   [Kim, Dong Hun] Dankook Univ, Coll Med, Dept Surg, Div Trauma Surg, 119 Dandae Ro, Cheonan 31116, South Korea.
C3 Dankook University; Dankook University; Dankook University Hospital;
   Dankook University; Dankook University
RP Kim, DH (通讯作者)，Dankook Univ, Coll Med, Dept Surg, Div Trauma Surg, 119 Dandae Ro, Cheonan 31116, South Korea.
EM saint7331@gmail.com
RI Heo, Yoonjung/JMQ-4158-2023
OI Heo, Yoonjung/0000-0002-8840-1794
FU  [2020-4- 43020]
FX Fund/Grant Support This research was supported by a research fund
   administered by Dankook University in the year 2020 (grant No. 2020-4-
   43020) . The funder had no role in the design, conduct, and reporting of
   this work.
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NR 67
TC 6
Z9 9
U1 0
U2 4
PU KOREAN SURGICAL SOCIETY
PI SEOUL
PA 3304HO, 101 DONG, BROWNSTONE SEOUL, 335, JUNGMIN-DONG, JUNG-GU, SEOUL,
   100-859, SOUTH KOREA
SN 2288-6575
EI 2288-6796
J9 ANN SURG TREAT RES
JI Ann. Surg. Treat. Res.
PD APR
PY 2023
VL 104
IS 4
BP 237
EP 247
DI 10.4174/astr.2023.104.4.237
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA D7MD0
UT WOS:000970521900007
PM 37051156
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Baig, SJ
   Priya, P
AF Baig, Sarfaraz Jalil
   Priya, Pallawi
TI Complexities in the management of a Richter's supraumbilical hernia with
   colocutaneous fistula in a patient with morbid obesity: A case report
   with a review of literature
SO JOURNAL OF MINIMAL ACCESS SURGERY
LA English
DT Review
DE Colocutaneous fistula; enterocutaneous fistula; Richter's hernia
AB Abdominal wall Richter's hernia is rare. The usual presentation is with irreducibility, obstruction and strangulation. Occasionally, enterocutaneous fistula containing small bowel has been reported. Management is frequently difficult due to emergency presentation and contamination. A 60-year-old male with a history of suture repair of umbilical hernia presented with faecal discharge from a long-standing recurrent hernia in the background of obesity and history of pulmonary embolism. There were no features of peritonitis or obstruction. After optimisation, we took the patient for a diagnostic laparoscopy with curative intent. Diagnostic laparoscopy revealed a Richter's hernia containing transverse colon. The patient was treated with resection of the involved colonic segment, anastomosis, complete excision of the fistula tract along with surrounding skin, negative pressure wound therapy and delayed skin closure. To our knowledge, this is the first report of a spontaneous umbilical Richter's hernia complicated with a colocutaneous fistula. Management was challenging due to emergency presentation, multiple comorbidities as well as faecal contamination. Minimal access approach may have helped by decreasing the contamination and surgical site infection in the postoperative period.
C1 [Baig, Sarfaraz Jalil; Priya, Pallawi] Belle Vue Clin, Dept Minimal Access Surg & Surg Gastroenterol, Kolkata, W Bengal, India.
RP Priya, P (通讯作者)，Belle Vue Clin, Dept Minimal Access Surg & Surg Gastroenterol, Kolkata, W Bengal, India.
EM drpallawipriya@gmail.com
RI Baig, Sarfaraz/AAP-9320-2020
CR Chen W, 2017, BMC SURG, V17, DOI 10.1186/s12893-017-0216-z
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   Rutkow IM, 2003, SURG CLIN N AM, V83, P1021, DOI 10.1016/S0039-6109(03)00131-2
NR 5
TC 1
Z9 1
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0972-9941
EI 1998-3921
J9 J MINIM ACCESS SURG
JI J. Minimal Access Surg.
PD APR-JUN
PY 2022
VL 18
IS 2
BP 308
EP 310
DI 10.4103/jmas.JMAS_99_21
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA D9LV2
UT WOS:000971879100025
PM 35313440
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Austin, CL
   Draper, B
   Larson, KW
   Thompson, SJ
AF Austin, Cindy L.
   Draper, Brian
   Larson, Kenneth W.
   Thompson, Simon J.
TI Biodegradable temporising matrix: use of negative pressure wound therapy
   shows a significantly higher success rate
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE biodegradable temporising matrix; dermal template; full-thickness burn;
   negative pressure wound therapy; NovoSorb BTM; NPWT; VAC;
   vacuum-assisted closure; wound; wound care; wound healing
ID VACUUM-ASSISTED CLOSURE; DERMAL REGENERATION TEMPLATE; TISSUE DEFECTS;
   POLYMER; NOVOSORB(TM); SUBSTITUTES; TRIAL
AB Objective: The purpose of this case series was to evaluate the efficacy of a synthetic biodegradable temporising matrix (BTM; PolyNovo Biomaterials Pty Ltd, Australia) and compare the outcome of BTM patients with and without negative pressure wound therapy (NPWT).
   Method: A retrospective chart review was conducted on patients admitted with deep full-thickness burns, traumatic or complex wound injuries treated with BTM. Electronic medical records and images were evaluated by a team of clinical professionals. Endpoints included: the measure of successful BTM integration; and comparison between patients treated with and without NPWT. Additional measures were BTM total surface area, BTM sites, timeliness of BTM application and any complications.
   Results: A total of 28 patients were evaluated and 23 (82.1%) demonstrated overall successful BTM integration. Patients treated with BTM in conjunction with NPWT (n=16) demonstrated a significantly higher (p=0.046) integration rate compared to patients treated without NPWT (n=12) (93.8% versus 58.3%, respectively). Patients treated with BTM with NPWT continued to successfully integrate and sustain favourable outcomes despite the presence of severe infection or the development of haematomas.
   Conclusion: A significantly higher integration rate was demonstrated when BTM was used in conjunction with NPWT. The results of this study further support the efficacy of successful integration of BTM as a replacement for tissue loss in the treatment of deep, full-thickness burns, traumatic and complex wound injuries, and particularly favourable outcomes with the use of NPWT. To the best of our knowledge, this is the first reported case series comparing the clinical outcomes of BTM with and without the use of NPWT.
C1 [Austin, Cindy L.; Thompson, Simon J.] Mercy Hosp, Trauma & Burn Res, Springfield, MO 65804 USA.
   [Draper, Brian; Larson, Kenneth W.] Mercy Hosp, Gen & Trauma Surg, Springfield, MO USA.
RP Austin, CL (通讯作者)，Mercy Hosp, Trauma & Burn Res, Springfield, MO 65804 USA.
EM Cindy.Austin@Mercy.Net
RI Austin, Cindy/HPD-4863-2023; Thompson, Simon/IUP-8006-2023
OI Thompson, Simon/0000-0003-0769-8555
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NR 37
TC 11
Z9 12
U1 0
U2 4
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2023
VL 32
IS 3
BP 159
EP 166
DI 10.12968/jowc.2023.32.3.159
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA E0LD3
UT WOS:000972543800005
PM 36930194
DA 2026-07-24
ER
PT J
AU Masson, R
   Parvathala, N
   Ma, E
   Shih, T
   Atluri, S
   Sayed, CJ
   Hogeling, M
   Shi, VY
   Hsiao, JL
AF Masson, Rahul
   Parvathala, Neha
   Ma, Elaine
   Shih, Terri
   Atluri, Swetha
   Sayed, Christopher J.
   Hogeling, Marcia
   Shi, Vivian Y.
   Hsiao, Jennifer L.
TI Efficacy of procedural treatments for pediatric hidradenitis
   suppurativa: A systematic review
SO PEDIATRIC DERMATOLOGY
LA English
DT Review
DE hidradenitis suppurativa; inflammatory disorders; pediatric; procedural
   treatments; systematic review
ID PRESSURE WOUND THERAPY; PHOTODYNAMIC THERAPY; CHILDREN; MANAGEMENT;
   PNEUMOMEDIASTINUM; CRYOINSUFFLATION; EXCISION; INFANTS; LASER
AB Hidradenitis suppurativa (HS) is a painful, inflammatory skin disease that has historically been understudied in the pediatric population. Procedural interventions, such as surgical excisions, skin grafts, and lasers, are important for comprehensive HS disease management. However, there is a lack of data on procedural treatments for HS in pediatric patients. The purpose of this study was to conduct a systematic review of the literature on the efficacy and safety of procedural treatments for HS in pediatric patients. In April 2022, MEDLINE and EMBASE databases were searched for articles on the efficacy of procedural treatments for HS in patients <18 years of age. Two independent reviewers extracted data from relevant studies. From 1974 to 2021, 23 articles with 81 patients were identified. Patients' Hurley stages included stage I (9.1%, 1/11), II (36.4%, 4/11), and III (54.5%, 6/11). The most extensively studied procedural interventions include negative pressure wound therapy (n = 30), surgical excision with skin graft/flap (n = 19), and endoscopic electrode or laser treatment (n = 11). In all, promising response rates for procedural management strategies were observed in the literature but the findings were largely based on case reports/series. Randomized controlled trials (RCTs), especially those geared toward minimally invasive procedural treatments, are needed to help guide clinicians on the most efficacious treatment modalities for pediatric patients with HS.
C1 [Masson, Rahul; Parvathala, Neha; Ma, Elaine] Univ Southern Calif, Keck Sch Med USC, Los Angeles, CA USA.
   [Shih, Terri] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA.
   [Atluri, Swetha] Univ Arizona, Coll Med, Tucson, AZ USA.
   [Sayed, Christopher J.] Univ North Carolina Chapel Hill, Dept Dermatol, Chapel Hill, NC USA.
   [Hogeling, Marcia] Univ Calif Los Angeles, Div Dermatol, Los Angeles, CA USA.
   [Shi, Vivian Y.] Univ Arkansas Med Sci, Dept Dermatol, Little Rock, AR USA.
   [Hsiao, Jennifer L.] Univ Southern Calif, Dept Dermatol, Los Angeles, CA USA.
   [Hsiao, Jennifer L.] USC Dermatol, 1441 Eastlake Ave,Ezralow Tower,Suite 5301, Los Angeles, CA 90033 USA.
C3 University of Southern California; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; David Geffen School of Medicine at UCLA;
   University of Arizona; University of North Carolina; University of North
   Carolina Chapel Hill; University of North Carolina School of Medicine;
   University of California System; University of California Los Angeles;
   University of Arkansas System; University of Arkansas Medical Sciences;
   University of Southern California
RP Hsiao, JL (通讯作者)，USC Dermatol, 1441 Eastlake Ave,Ezralow Tower,Suite 5301, Los Angeles, CA 90033 USA.
EM j.hsiao.publications@gmail.com
RI ; Sayed, Christopher/AAC-3343-2020; Hsiao, Jennifer/ABB-4999-2020;
   /AAJ-4045-2021
OI Atluri, Swetha/0000-0002-1416-5119; Shi, Vivian/0000-0002-7510-9428;
   Sayed, Christopher/0000-0003-3201-4637; Hsiao,
   Jennifer/0000-0002-8843-3630; 
CR Alharbi Z, 2012, BMC DERMATOL, V12, DOI 10.1186/1471-5945-12-9
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NR 56
TC 10
Z9 10
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-8046
EI 1525-1470
J9 PEDIATR DERMATOL
JI Pediatr. Dermatol.
PD JUL
PY 2023
VL 40
IS 4
BP 595
EP 605
DI 10.1111/pde.15331
EA APR 2023
PG 11
WC Dermatology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Pediatrics
GA M5TG4
UT WOS:000974710800001
PM 37092729
OA hybrid
DA 2026-07-24
ER
PT J
AU Chen, CH
   Lee, YC
   Wu, YC
   Lee, CH
   Tsai, YJ
   Liu, YC
   Chen, YH
   Wang, FY
   Chang, SC
AF Chen, Chih-Heng
   Lee, Yi-Ching
   Wu, Yi-Chun
   Lee, Chi-Hung
   Tsai, Yuan-Jen
   Liu, Yung-Ching
   Chen, Yu-Han
   Wang, Fu-Yu
   Chang, Shun-Cheng
TI Multidisciplinary Strategies With Real-Time Fluorescence Images and
   Negative Pressure Wound Therapy to Manage Organ/Space Surgical Site
   Infection in Transplanted Kidneys
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE kidney transplant; renal transplant; organ-space surgical site
   infection; fluorescence imaging; negative-pressure wound therapy;
   bioburden detection
ID CARE; MORTALITY; IMPACT; DEVICE
AB BackgroundSurgical site infection (SSI) after kidney transplantation can severely compromise graft function and prolong hospital stay. Organ/space SSI (osSSI) is a severe type of SSI associated with a significantly higher mortality rate.Aims and ObjectivesThis study aims to provide new strategies of managing (osSSI) after kidney transplant and other high-risk wound infections.MethodThis is a single-center, retrospective study that analyzed the treatment outcomes of 4 patients who developed osSSI after kidney transplant at Shuang-Ho Hospital. The management strategy included real-time fluorescence imaging with MolecuLight, negative-pressure wound therapy (NPWT) with Si-Mesh, and incisional NPWT (iNPWT).ResultThe average length of hospital stay was 18 days (range, 12-23 days). During hospitalization, all patients obtained high-quality debridement under real-time fluorescence image confirmation. The average duration of NPWT was 11.8 days (range, 7-17 days) and iNPWT was 7 days. All transplanted kidneys were preserved with normal function after 6 months of follow-up.ConclusionsOur strategies with real-time fluorescence imaging provide a novel and effective method that can be used in adjunct with the standard of care for managing osSSI after kidney transplantation. More studies are warranted to validate the efficacy of our approach.
C1 [Chen, Chih-Heng; Lee, Yi-Ching] Taipei Med Univ, Coll Med, Sch Med, Taipei, Taiwan.
   [Wu, Yi-Chun] Taipei Med Univ, Shuang Ho Hosp, Integrated Burn & Wound Care Ctr, Dept Surg,Div Plast Surg, New Taipei City, Taiwan.
   [Wu, Yi-Chun] Natl Yang Ming Chiao Tung Univ, Dept Biomed Engn, Taipei, Taiwan.
   [Lee, Chi-Hung] Taipei Med Univ, Shuang Ho Hosp, Div Infect Dis, New Taipei City, Taiwan.
   [Tsai, Yuan-Jen] Taipei Med Univ, Shuang Ho Hosp, New Taipei City, Taiwan.
   [Liu, Yung-Ching] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Infect Dis, New Taipei City, Taiwan.
   [Chen, Yu-Han; Wang, Fu-Yu; Chang, Shun-Cheng] Taipei Med Univ, Shuang Ho Hosp, Integrated Burn & Wound Care Ctr, Dept Surg,Div Plast Surg, Taipei, Taiwan.
   [Wang, Fu-Yu] Cabrini Hosp, Melbourne, Vic, Australia.
   [Chang, Shun-Cheng] Taipei Med Univ, Coll Med, Sch Med, Dept Surg, Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University; National Yang Ming
   Chiao Tung University; Taipei Medical University; Taipei Medical
   University; Taipei Medical University; Taipei Medical University; Shuang
   Ho Hospital; Cabrini Health; Taipei Medical University
RP Chang, SC (通讯作者)，Taipei Med Univ, Shuang Ho Hosp, Coll Med, Integrated Burn & Wound Care Ctr,Dept Surg,Div Pl, 291 Zhongzheng Rd, New Taipei City 235, Taiwan.
EM b101105115@tmu.edu.tw; markichael86214@gmail.com; 18002@s.tmu.edu.tw;
   15526@s.tmu.edu.tw; uarejudy@gmail.com; yungching@tmu.edu.tw;
   18114@s.tmu.edu.tw; onefuyu@gmail.com; csc901515@gmail.com
RI ; Wu, Yi-Chun/F-7934-2012
OI Tsai, Yuan-Jen/0009-0000-4464-4105; 
CR Abbo LM, 2019, CLIN TRANSPLANT, V33, DOI 10.1111/ctr.13589
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   Centers for Disease Control and Prevention, 2021, National Healthcare Safety Network (NHSN) Patient Safety Component Manual
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   Coello R, 2005, J HOSP INFECT, V60, P93, DOI 10.1016/j.jhin.2004.10.019
   Cottrill R, 2013, J WOUND CARE, V22, P214, DOI 10.12968/jowc.2013.22.4.214
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   Ho D, 2010, J AM COLL SURGEONS, V211, P99, DOI 10.1016/j.jamcollsurg.2010.02.055
   Hodzic J, 2003, UROLOGE A, V42, P1097, DOI 10.1007/s00120-003-0299-2
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Hurley CM, 2019, J WOUND CARE, V28, P438, DOI 10.12968/jowc.2019.28.7.438
   Iesari S, 2017, EXP CLIN TRANSPLANT, V15, P222, DOI 10.6002/ect.2014.0236
   Janssen AHJ, 2016, J WOUND CARE, V25, P154, DOI 10.12968/jowc.2016.25.3.154
   Jones Laura M, 2020, Future Microbiol, V15, P319, DOI [10.2217/fmb-2019-0279, 10.2217/fmb-2019-0279]
   Kirkland KB, 1999, INFECT CONT HOSP EP, V20, P725, DOI 10.1086/501572
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   Wszola M, 2013, TRANSPLANTATION, V95, P878, DOI 10.1097/TP.0b013e318281b953
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NR 35
TC 2
Z9 2
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD APR
PY 2023
VL 90
IS 1
SU 1
BP S60
EP S67
DI 10.1097/SAP.0000000000003379
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA E3WX0
UT WOS:000974892800011
PM 37075295
DA 2026-07-24
ER
PT J
AU Sweere, V
   Sliepen, J
   Haidari, S
   Depypere, M
   Mertens, M
   IJpma, F
   Metsemakers, WJ
   Govaert, G
AF Sweere, Vera
   Sliepen, Jonathan
   Haidari, Susan
   Depypere, Melissa
   Mertens, Maarten
   IJpma, Frank
   Metsemakers, Willem-Jan
   Govaert, Geertje
TI Use of negative pressure wound therapy in patients with fracture-related
   infection more than doubles the risk of recurrence
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Fracture-related infection; Osteomyelitis; Infection; Fracture; Bone
   infection; Wound; Negative pressure wound therapy; Complications;
   Re-infection; Recurrence of infection; Orthoplastic Surgery
ID COMPLICATIONS; MANAGEMENT
AB Purpose: Fracture-related infection (FRI) is one of the most serious complications in orthopedic trauma surgery. Despite its widespread use, the role of Negative Pressure Wound Therapy (NPWT) remains con-troversial in the management pathway of FRI. The aim of this study was to assess the relationship be-tween the application of NPWT and its duration and recurrence of infection in operatively treated FRI patients.Patients and Methods: This is a retrospective cohort study based on the FRI database of three level 1 Trauma Centres. Included patients had to be at least 16 years of age and surgically treated for FRI be-tween January 1st 2015 and September 1st 2020. Patients were subdivided in either the NPWT group, when NPWT was applied as part of the FRI treatment, or in the control group, when no NPWT had been applied. To limit confounding, patients were excluded if they (also) underwent NPWT prior to the diag-nosis of FRI. The relation between the duration of NPWT during FRI treatment and the recurrence rate of infection was analyzed using a multivariable logistic regression model.Results: A total of 263 patients were included, 99 in the NPWT group and 164 in the control group. The median duration of NPWT was 18.0 (IQR 15.8) days. In the NPWT group, 28 patients (28.3%) developed a recurrent FRI. In the control group, 19 patients (11.6%) had a recurrent FRI (p = 0.001, 95% CI [0.174 - 0.635]). In the NPWT group there were no significant differences in baseline characteristics between the recurrence and non-recurrence group. The duration of NPWT was associated with a higher risk of recurrence of infection (p = 0.013, OR 1.036, 95% CI [1.008 - 1.066]).Conclusion: Delayed wound closure with the application of NPWT increased the risk of recurrence of infection in patients with soft tissue defects after FRI treatment. Therefore, it is advised to consider NPWT only as a short-term (e.g. few days) necessity to bridge the period until definitive wound closure can be established. (c) 2022 The Authors. Published by Elsevier Ltd.
C1 [Sweere, Vera; Haidari, Susan; Govaert, Geertje] Univ Med Ctr Utrecht, Dept Trauma Surg, Utrecht, Netherlands.
   [Sliepen, Jonathan; IJpma, Frank] Univ Med Ctr Groningen, Dept Trauma Surg, Groningen, Netherlands.
   [Depypere, Melissa] Univ Hosp Leuven, Dept Lab Med, Leuven, Belgium.
   [Mertens, Maarten; Metsemakers, Willem-Jan] Univ Hosp Leuven, Dept Trauma Surg, Leuven, Belgium.
   [Metsemakers, Willem-Jan] Univ Leuven, KU Leuven, Dept Dev & Regenerat, Leuven, Belgium.
   [Govaert, Geertje] Univ Med Ctr Utrecht UMCU, Dept Trauma Surg, POB 85500,Room G04 228, NL-3508GA Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; University of
   Groningen; KU Leuven; University Hospital Leuven; KU Leuven; University
   Hospital Leuven; KU Leuven
RP Govaert, G (通讯作者)，Univ Med Ctr Utrecht UMCU, Dept Trauma Surg, POB 85500,Room G04 228, NL-3508GA Utrecht, Netherlands.
EM g.a.m.govaert@umcutrecht.nl
RI Metsemakers, Willem-Jan/F-8647-2016; IJpma, Frank/AAH-6350-2019;
   Sliepen, Jonathan/JOZ-3183-2023; depypere, melissa/AAA-7578-2021
OI Metsemakers, Willem-Jan/0000-0002-4114-9093; IJpma,
   Frank/0000-0002-9420-2732; Mertens, Maarten/0000-0003-1256-5183;
   Sliepen, Jonathan/0000-0003-0176-112X; Haidari,
   Susan/0000-0003-0425-7543; 
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NR 29
TC 10
Z9 12
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD DEC
PY 2022
VL 53
IS 12
BP 3938
EP 3944
DI 10.1016/j.injury.2022.10.014
EA NOV 2022
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA E4MA8
UT WOS:000975287900013
PM 36424686
OA Green Submitted, Green Accepted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Keshvari, A
   Mollamohammadi, L
   Keramati, MR
   Behboudi, B
   Fazeli, MS
   Kazemeini, A
   Naseri, A
   Shahmohammadi, E
   Foroutani, L
   Ayati, A
   Tayebi, A
   Sajjadian, Z
   Hadizadeh, A
   Ahmadi-Tafti, SM
AF Keshvari, Amir
   Mollamohammadi, Leila
   Keramati, Mohammad Reza
   Behboudi, Behnam
   Fazeli, Mohammad Sadegh
   Kazemeini, Alireza
   Naseri, Amirhossein
   Shahmohammadi, Elnaz
   Foroutani, Laleh
   Ayati, Aryan
   Tayebi, Amirhossein
   Sajjadian, Zahra
   Hadizadeh, Alireza
   Ahmadi-Tafti, Seyed-Mohsen
TI Pirfenidone in fibrotic hypersensitivity pneumonitis: a double-blind,
   randomised clinical trial of efficacy and safety
SO UPDATES IN SURGERY
LA English
DT Article
DE Colorectal Cancer; Anastomotic leakage; Negative-pressure wound therapy;
   Colon surgery; Endoscopic treatment; Endo-sponge
ID LOW ANTERIOR RESECTION; RECTAL-CANCER; ENDO-SPONGE; ANASTOMOTIC LEAKAGE;
   COMPLICATIONS; SURGERY; MANAGEMENT; THERAPY; COLON
AB Anastomotic leakage is one of the major complications of colorectal surgery, which might lead to reoperation, increased hospital stays, further intervention and mortality. Vacuum-assisted closure by devices such as Endo-SPONGE (R) produced by (B- Braun Medical B.V.) is currently being used to treat leakage and fistula. In this study, we aimed to assess the handmade vacuum-assisted sponge drain for anastomotic leakage following low anterior resection. This prospective study included 22 patients who had undergone sponge drain placement to treat anastomotic leakage. All patients had anastomotic leaks or defects after left anterior rectal resection (LAR) without ileostomy. They were treated with neo-adjuvant chemotherapy before the surgery and then subjected to rigid recto-sigmoidoscopy for 30 days following the operation. Any sign of leakage, such as perianal and pelvic pain, was immediately identified and followed up with a CT scan and another recto-sigmoidoscopy. Twenty-two patients were enrolled in this study, 12 men (54.5%) and 10 women (47.4%). All patients had received neoadjuvant chemotherapy with an average follow-up of 22.30 +/- 3.81. 75% of patients ( 15 cases) were successfully treated, and 17 patients (85%) underwent successful ostomy closure. Treatment failed in 5 patients (25%), including three men and two women. This study shows that handmade vacuum-assisted sponge drain is a cost-effective method of anastomotic leakage management with efficacy similar to that of Endo-SPONGE (R)
C1 [Keshvari, Amir; Mollamohammadi, Leila; Keramati, Mohammad Reza; Behboudi, Behnam; Fazeli, Mohammad Sadegh; Kazemeini, Alireza; Naseri, Amirhossein; Ahmadi-Tafti, Seyed-Mohsen] Univ Tehran Med Sci, Imam Hosp Complex, Colorectal Res Ctr, Tehran, Iran.
   [Keshvari, Amir; Mollamohammadi, Leila; Keramati, Mohammad Reza; Behboudi, Behnam; Fazeli, Mohammad Sadegh; Kazemeini, Alireza; Naseri, Amirhossein; Ahmadi-Tafti, Seyed-Mohsen] Univ Tehran Med Sci, Dept Surg, Div Colorectal Surg, Tehran 1419733141, Iran.
   [Shahmohammadi, Elnaz; Foroutani, Laleh; Ayati, Aryan; Tayebi, Amirhossein; Hadizadeh, Alireza] Univ Tehran Med Sci, Cardiovasc Res Inst, Res Ctr Adv Technol Cardiovasc Med, Tehran, Iran.
   [Sajjadian, Zahra] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Regenerat Med, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Academic Center for
   Education, Culture & Research (ACECR)
RP Ahmadi-Tafti, SM (通讯作者)，Univ Tehran Med Sci, Imam Hosp Complex, Colorectal Res Ctr, Tehran, Iran.; Ahmadi-Tafti, SM (通讯作者)，Univ Tehran Med Sci, Dept Surg, Div Colorectal Surg, Tehran 1419733141, Iran.; Hadizadeh, A (通讯作者)，Univ Tehran Med Sci, Cardiovasc Res Inst, Res Ctr Adv Technol Cardiovasc Med, Tehran, Iran.
EM ali1375hadi@gmail.com; smahmadit@sina.tums.ac.ir
RI hadizadeh, alireza/KHY-0892-2024; Ayati, Aryan/CAJ-1580-2022; Tayebi,
   Amirhossein/JRY-0103-2023; Keshvari, Amir/GYJ-0402-2022; Foroutani,
   Laleh/KPA-1877-2024; Keramati, Mohammad Reza/B-4144-2013; Ahmadi Tafti,
   Seyed Mohsen/AAS-4302-2020
OI hadizadeh, alireza/0000-0003-0821-7557; Ayati,
   Aryan/0000-0002-0241-6865; Foroutani, Laleh/0000-0002-2818-8477; Tayebi,
   Amirhossein/0000-0002-6327-7125; Naseri, Amirhosein/0000-0001-8548-1330;
   Ahmadi Tafti, Seyed Mohsen/0000-0002-3595-8353
CR [Anonymous], 2013, GE Port J Gastroenterol
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NR 32
TC 5
Z9 7
U1 0
U2 3
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD JUN
PY 2023
VL 75
IS 4
BP 847
EP 854
DI 10.1007/s13304-023-01518-3
EA APR 2023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J4IH0
UT WOS:000976762900001
PM 37086350
DA 2026-07-24
ER
PT J
AU Pines, G
   Lazar, L
   Mashni, I
   Miller, R
   Gal, E
AF Pines, Guy
   Lazar, Li Or
   Mashni, Ibrahim
   Miller, Rafael
   Gal, Eyal
TI Modified Endoscopic Vacuum-Assisted Closure (EVAC) for Esophageal
   Perforation: a Promising and Simplified Technique - Report of Three
   Patients
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Esophageal perforation; Stent; Endoscopic VAC; Mediastinitis
ID THERAPY; DRAINAGE; RUPTURE; STENT
AB Intrathoracic esophageal perforation is a devastating event bearing high mortality rates. Prompt recognition and aggressive treatment are key. Traditionally, most patients required surgical treatment, but recently, endoscopic techniques, mainly endoscopic vacuum-assisted closure (EVAC), have been recognized as a valuable alternative in selected patients. Herein, we describe a novel technique in which a nasogastric tube (NGT) was placed endoscopically into a mediastinal abscess and covered with a self-expanding metal stent to treat esophageal defects in three patients.
C1 [Pines, Guy; Lazar, Li Or; Mashni, Ibrahim] Kaplan Med Ctr, Dept Thorac Surg, Rehovot, Israel.
   [Pines, Guy; Lazar, Li Or; Mashni, Ibrahim; Miller, Rafael; Gal, Eyal] Hebrew Univ Jerusalem, Fac Med, Rehovot, Israel.
   [Pines, Guy; Miller, Rafael] Kaplan Med Ctr, Dept Surg, Rehovot, Israel.
   [Gal, Eyal] Kaplan Med Ctr, Dept Gastroenterol & Liver Dis, Rehovot, Israel.
C3 Hebrew University of Jerusalem; Kaplan Medical Center; Hebrew University
   of Jerusalem; Hebrew University of Jerusalem; Kaplan Medical Center;
   Hebrew University of Jerusalem; Kaplan Medical Center
RP Pines, G (通讯作者)，Kaplan Med Ctr, Dept Thorac Surg, Rehovot, Israel.; Pines, G (通讯作者)，Hebrew Univ Jerusalem, Fac Med, Rehovot, Israel.; Pines, G (通讯作者)，Kaplan Med Ctr, Dept Surg, Rehovot, Israel.
EM Guypi@clalit.org.il
RI Pines, Guy/A-4251-2017
OI Pines, Guy/0000-0003-2923-660X
CR Aziz M, 2021, ENDOSC INT OPEN, V09, pE1371, DOI 10.1055/a-1508-5947
   Bi YH, 2019, RADIOL MED, V124, P1253, DOI 10.1007/s11547-019-01074-0
   Han XW, 2016, J SURG ONCOL, V114, P725, DOI 10.1002/jso.24384
   de Moura DTH, 2019, WORLD J GASTRO ENDOS, V11, P329, DOI 10.4253/wjge.v11.i5.329
   Kuehn F, 2016, J GASTROINTEST SURG, V20, P237, DOI 10.1007/s11605-015-3044-4
   Loske G, 2011, ENDOSCOPY, V43, P540, DOI 10.1055/s-0030-1256345
   Newton NJ, 2017, DIS ESOPHAGUS, V30, DOI 10.1111/dote.12531
   Pines G, 2018, J LAPAROENDOSC ADV S, V28, P33, DOI 10.1089/lap.2017.0318
   Sharp G, 2021, ANZ J SURG, V91, P537, DOI 10.1111/ans.16581
   Sohda M, 2020, ESOPHAGUS-TOKYO, V17, P230, DOI 10.1007/s10388-020-00744-7
   Wu G, 2017, J TRAUMA ACUTE CARE, V82, P141, DOI 10.1097/TA.0000000000001272
   Yu LL, 2018, J INT MED RES, V46, P1528, DOI 10.1177/0300060517752995
NR 12
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD OCT
PY 2023
VL 85
IS SUPPL 2
SU 2
SI SI
BP 597
EP 601
DI 10.1007/s12262-023-03793-1
EA APR 2023
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CA3A1
UT WOS:000978061300001
DA 2026-07-24
ER
PT J
AU Tingting, S
   Xinyue, F
   Tiantian, Y
   Xiao, A
   Rui, L
   Feng, L
   Daohong, L
   Zhirui, L
   Guoqi, W
AF Tingting, Sun
   Xinyue, Feng
   Tiantian, Yang
   Xiao, An
   Rui, Li
   Feng, Lin
   Daohong, Liu
   Zhirui, Li
   Guoqi, Wang
TI Comparison of the effects of negative pressure wound therapy and
   negative pressure wound therapy with instillation on wound healing in a
   porcine model
SO FRONTIERS IN SURGERY
LA English
DT Article
DE NPWT; instillation; wound healing; staphylococcus aureus; virulence
ID VACUUM-ASSISTED CLOSURE; EXTRACELLULAR ADHERENCE PROTEIN;
   STAPHYLOCOCCUS-AUREUS; BIOFILM FORMATION; CONJUNCTION; RESPONSES
AB BackgroundNegative pressure wound therapy with instillation (NPWTi) is a novel method based on standard negative pressure wound therapy (NPWT). This study aimed to compare the effects of standard NPWT and NPWTi on bioburden and wound healing in a Staphylococcus aureus (S.aureus) infected porcine model.MethodsGreen fluorescent protein-labeled S.aureus infected wounds were created on the back of porcine. Wounds were treated with NPWT or NPWT with instillation (saline). The tissue specimens were harvested on days 0 (12 h after bacterial inoculation), 2, 4, 6, and 8 at the center of wound beds. Viable bacterial counts, laser scanning confocal microscopy, PCR, western blot, and histological analysis were performed to assess virulence and wound healing.ResultsThe bacterial count in the NPWTi group was lower than that of the NPWT group and the difference was statistically significant on day 2, day 4, day 6, and day 8 (P < 0.05). The expression levels of agrA, Eap, Spa, and Hla genes of the NPWTi group were significantly lower than that of the NPWT group on day 8 (P < 0.05). The bacterial invasion depth of the NPWTi group was significantly lower than that of the NPWT group on day 2, day 4, day 6, and day 8 (P < 0.05). Though the NPWTi group showed a significantly increased expression of bFGF and VEGF than that of the NPWT group in the early time (P < 0.05), NPWTi cannot lead to better histologic parameters than the NPWT group (P > 0.05).ConclusionOur results demonstrated that NPWTi induced a better decrease in bacterial burden and virulence compared with standard NPWT. These advantages did not result in better histologic parameters on the porcine wound model.
C1 [Tingting, Sun; Xiao, An; Rui, Li; Feng, Lin; Zhirui, Li] Peoples Liberat Army Gen Hosp, Dept Orthopaed, Hainan Hosp Chinese, Sanya, Peoples R China.
   [Xinyue, Feng] Peoples Liberat Army Gen Hosp, Dept Dermatol, Hainan Hosp Chinese, Sanya, Peoples R China.
   [Tiantian, Yang] Wenchang Peoples Hosp, Dept Anesthesiol, Wenchang, Peoples R China.
   [Daohong, Liu] Peoples Liberat Army Gen Hosp, Sr Dept Orthoped, Med Ctr 4, Beijing, Peoples R China.
   [Daohong, Liu] Peoples Liberat Army Gen Hosp, Dept Orthoped, Med Ctr 8, Beijing, Peoples R China.
   [Daohong, Liu; Zhirui, Li; Guoqi, Wang] Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Orthoped, Sports Med & Rehabil, Beijing, Peoples R China.
   [Guoqi, Wang] Peoples Liberat Army Gen Hosp, Dept Pediat, Med Ctr Chinese 1, Beijing, Peoples R China.
   [Guoqi, Wang] Chinese Peoples Liberat Army Gen Hosp, Sr Dept Pediat, Seventh Med Ctr, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese People's Liberation Army
   General Hospital; Chinese People's Liberation Army General Hospital;
   Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese People's Liberation Army
   General Hospital
RP Feng, L; Zhirui, L (通讯作者)，Peoples Liberat Army Gen Hosp, Dept Orthopaed, Hainan Hosp Chinese, Sanya, Peoples R China.; Daohong, L (通讯作者)，Peoples Liberat Army Gen Hosp, Sr Dept Orthoped, Med Ctr 4, Beijing, Peoples R China.; Daohong, L (通讯作者)，Peoples Liberat Army Gen Hosp, Dept Orthoped, Med Ctr 8, Beijing, Peoples R China.; Daohong, L; Zhirui, L; Guoqi, W (通讯作者)，Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Orthoped, Sports Med & Rehabil, Beijing, Peoples R China.; Guoqi, W (通讯作者)，Peoples Liberat Army Gen Hosp, Dept Pediat, Med Ctr Chinese 1, Beijing, Peoples R China.; Guoqi, W (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Sr Dept Pediat, Seventh Med Ctr, Beijing, Peoples R China.
EM guoqi71@126.com; lzr860514@163.com; 13810085005@139.com;
   lyf1011@aliyun.com
FU Hainan Province Clinical Medical Center; projects of military logistics
   research foundation [AWS17J004]
FX This research is supported by Hainan Province Clinical Medical Center
   and the projects of military logistics research foundation (No.
   AWS17J004) to ZL.
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NR 38
TC 3
Z9 4
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD APR 17
PY 2023
VL 10
AR 1080838
DI 10.3389/fsurg.2023.1080838
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA E9JW8
UT WOS:000978629200001
PM 37139193
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Awad, SS
   Stern, JD
   Milne, CT
   Dowling, SG
   Sotomayor, R
   Ayello, EA
   Aguirre, LJF
   Khalaf, BZ
   Gould, LJ
   Desvigne, MN
   Chaffin, AE
AF Awad, Samir S.
   Stern, James D.
   Milne, Cathy T.
   Dowling, Shane G.
   Sotomayor, Ron
   Ayello, Elizabeth A.
   Aguirre, Leandro J. Feo
   Khalaf, Basil Z.
   Gould, Lisa J.
   Desvigne, Michael N.
   Chaffin, Abigail E.
TI Surgical Reconstruction of Stage 3 and 4 Pressure Injuries: A Literature
   Review and Proposed Algorithm from an Interprofessional Working Group
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Review
DE bioscaffold; negative-pressure wound therapy; ovine forestomach matrix;
   pressure injury; surgical reconstruction
ID PORCINE EXTRACELLULAR-MATRIX; URINARY-BLADDER MATRIX; QUALITY-OF-LIFE;
   PLACENTAL MEMBRANE; CLINICAL-OUTCOMES; WOUND THERAPY; DEAD SPACE; ULCER;
   FLAP; MANAGEMENT
AB OBJECTIVEStage 3 and 4 pressure injuries (PIs) present an enormous societal burden with no clearly defined interventions for surgical reconstruction. The authors sought to assess, via literature review and a reflection/evaluation of their own clinical practice experience (where applicable), the current limitations to the surgical intervention of stage 3 or 4 PIs and propose an algorithm for surgical reconstruction.METHODSAn interprofessional working group convened to review and assess the scientific literature and propose an algorithm for clinical practice. Data compiled from the literature and a comparison of institutional management were used to develop an algorithm for the surgical reconstruction of stage 3 and 4 PIs with adjunctive use of negative-pressure wound therapy and bioscaffolds.RESULTSSurgical reconstruction of PI has relatively high complication rates. The use of negative-pressure wound therapy as adjunctive therapy is beneficial and widespread, leading to reduced dressing change frequency. The evidence for the use of bioscaffolds both in standard wound care and as an adjunct to surgical reconstruction of PI is limited. The proposed algorithm aims to reduce complications typically seen with this patient cohort and improve patient outcomes from surgical intervention.CONCLUSIONSThe working group has proposed a surgical algorithm for stage 3 and 4 PI reconstruction. The algorithm will be validated and refined through additional clinical research.
C1 [Awad, Samir S.] Baylor Coll Med, Surg, Houston, TX 77030 USA.
   [Awad, Samir S.] Michael E DeBakey VA Med Ctr, Surg, Houston, TX 77030 USA.
   [Stern, James D.] Mem Reg Hosp, Hollywood, FL USA.
   [Milne, Cathy T.] Connecticut Clin Nursing Associates, Bristol, CT USA.
   [Dowling, Shane G.] Aroa Biosurg Ltd, Auckland, New Zealand.
   [Sotomayor, Ron] Advent Hlth, Orlando, FL USA.
   [Ayello, Elizabeth A.] Ayello Harris & Associates Inc, Copake, NY USA.
   [Aguirre, Leandro J. Feo] Palm Beach Hlth Network, Del Ray Beach, FL USA.
   [Khalaf, Basil Z.] MEDIKAL Grp, Houston, TX USA.
   [Gould, Lisa J.] South Shore Hlth, Weymouth, MA USA.
   [Desvigne, Michael N.] Desvigne Plast Surg & Abrazo Hlth, Scottsdale, AZ USA.
   [Chaffin, Abigail E.] Tulane Univ, Div Plast Surg, New Orleans, LA USA.
   [Chaffin, Abigail E.] MedCentris Wound Healing Inst, New Orleans, LA USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   Medical Hospital; Adventist Health Services; AdventHealth;
   (AdventHealth) Central Florida Division; Central Florida Hospital -
   South; AdventHealth Orlando; Tulane University
RP Awad, SS (通讯作者)，Baylor Coll Med, Surg, Houston, TX 77030 USA.; Awad, SS (通讯作者)，Michael E DeBakey VA Med Ctr, Surg, Houston, TX 77030 USA.
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NR 110
TC 8
Z9 9
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAY
PY 2023
VL 36
IS 5
BP 249
EP 258
DI 10.1097/01.ASW.0000922708.95424.88
PG 10
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA E9PY6
UT WOS:000978787400007
PM 37079788
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Jha, NK
   Shafique, M
   Thomas, R
   Cruz, SP
   Tariq, G
   Kiraly, L
AF Jha, Neerod Kumar
   Shafique, Muhammad
   Thomas, Raisy
   Cruz, Salvacion Pangilinan
   Tariq, Gulnaz
   Kiraly, Laszlo
TI Sternal Wound Management in Pediatric Cardiac Surgical Patients: A Novel
   Strategic Interprofessional Approach
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE cardiac; infection; interprofessional; management; pediatric; sternum;
   surgery; wound care
ID INFECTIONS
AB OBJECTIVEInformation on sternal wound management in children after cardiac surgery is limited. The authors formulated a pediatric sternal wound care schematic incorporating concepts of interprofessional wound care and the wound bed preparation paradigm including negative-pressure wound therapy and surgical techniques to expedite and streamline wound care in children.METHODSAuthors assessed knowledge about sternal wound care among nurses, surgeons, intensivists, and physicians in a pediatric cardiac surgical unit regarding the latest concepts such as wound bed preparation, NERDS and STONEES criteria for wound infection, and early use of negative-pressure wound therapy or surgery. Management pathways for superficial and deep sternal wounds and a wound progress chart were prepared and introduced in practice after education and training.RESULTSThe cardiac surgical unit team members demonstrated a lack of knowledge about the current concepts of wound care, although this improved after education. The newly proposed management pathway/algorithm for superficial and deep sternal wounds and a wound progress assessment chart were introduced into practice. Results in 16 observed patients were encouraging, leading to complete healing and no mortality.CONCLUSIONSManaging pediatric sternal wounds after cardiac surgery can be streamlined by incorporating evidence-based current wound care concepts. In addition, the early introduction of advanced care techniques with appropriate surgical closure further improves outcomes. A management pathway for pediatric sternal wounds is beneficial.
C1 [Jha, Neerod Kumar; Thomas, Raisy; Kiraly, Laszlo] Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates.
   [Shafique, Muhammad] Sheikh Khalifa Med City, Internal Med, Abu Dhabi, U Arab Emirates.
   [Cruz, Salvacion Pangilinan] Sheikh Khalifa Med City, Wound Care, Abu Dhabi, U Arab Emirates.
   [Tariq, Gulnaz] Wound Care Dept, Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates.
C3 Sheikh Khalifa Medical City; Sheikh Khalifa Medical City; Sheikh Khalifa
   Medical City; Sheikh Khalifa Medical City
RP Jha, NK (通讯作者)，Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates.
RI Kiraly, Laszlo/AHB-1719-2022
CR Anger J, 2015, REV BRAS CIR CARDIOV, V30, P114, DOI 10.5935/1678-9741.20140033
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   National Healthcare Safety Network, EVENT
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NR 11
TC 5
Z9 6
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAY
PY 2023
VL 36
IS 5
BP 259
EP 266
DI 10.1097/01.ASW.0000924128.52669.ea
PG 8
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA E9PY6
UT WOS:000978787400008
PM 37079789
DA 2026-07-24
ER
PT J
AU Gonzalez, MG
   Barske, ME
   Kjellsson, KB
   Saboda, K
   Reed, HA
   Hill, MG
AF Gonzalez, Maritza G. G.
   Barske, M. Elisa
   Kjellsson, Kristine B. B.
   Saboda, Kathylynn
   Reed, Heather A. A.
   Hill, Meghan G. G.
TI Topical negative pressure wound therapy to prevent wound complications
   following caesarean delivery in high-risk obstetric patients: A
   randomised controlled trial
SO AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
LA English
DT Article
DE caesarean incision; wound breakdown; wound infection; wound separation;
   wound vacuum
ID OBESE WOMEN
AB Background and AimsWe investigated whether the use of a prophylactic negative pressure wound therapy (NPWT) system in women undergoing caesarean would decrease wound complications in a high-risk population. Materials and MethodsA randomised controlled trial was performed. Women with risk factors for wound complications undergoing caesarean delivery were randomised to a standard dressing or NPWT placed over their caesarean wound. We standardised the closure of the subcutaneous fat and skin layers, both with Vicryl. Patients were followed for wound complications for up to 6 weeks after their caesareans. The incidence of wound complications was the primary outcome. The single-use NPWT system, PICO, was provided by Smith and Nephew for use in this trial. The trial was registered on , # NCT03082664. ResultsWe report here on 154 women randomised to either a standard dressing or to the NPWT. Wound complication rates were equivalent between groups, with 19.4 and 19.7% (P = 0.43) of women with follow-up information available experiencing wound complications. ConclusionWe found no difference in wound complications in women with risk factors treated with a prophylactic NPWT system or standard wound dressing at the time of caesarean birth.
C1 [Gonzalez, Maritza G. G.; Barske, M. Elisa; Kjellsson, Kristine B. B.; Reed, Heather A. A.; Hill, Meghan G. G.] Univ Arizona, Dept Obstet & Gynecol, Tucson, AZ USA.
   [Saboda, Kathylynn] Univ Arizona, Canc Ctr, Biostat & Bioinformat Shared Serv, Tucson, AZ USA.
   [Gonzalez, Maritza G. G.] Univ Chicago, Dept Obstet & Gynecol, 5841 S Maryland Ave MC250, Chicago, IL 60637 USA.
C3 University of Arizona; University of Arizona; University of Chicago
RP Gonzalez, MG (通讯作者)，Univ Chicago, Dept Obstet & Gynecol, 5841 S Maryland Ave MC250, Chicago, IL 60637 USA.
EM mggonzalez@bsd.uchicago.edu
FU Smith and Nephew Funding Source: Medline
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NR 14
TC 4
Z9 4
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0004-8666
EI 1479-828X
J9 AUST NZ J OBSTET GYN
JI Aust. N. Z. J. Obstet. Gynaecol.
PD AUG
PY 2023
VL 63
IS 4
BP 516
EP 520
DI 10.1111/ajo.13675
EA MAY 2023
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FO8Q7
UT WOS:000979992800001
PM 37140175
DA 2026-07-24
ER
PT J
AU Pachuau, L
   Wu, XY
   Fu, ML
   Cui, XM
   Chen, XD
AF Pachuau, Lalrintluangi
   Wu, Xiao-Yan
   Fu, Mu-Lan
   Cui, Xiao-Mei
   Chen, Xiao-Dong
TI Surgical Treatment for Chest "Lock" Keloid Using Autologous
   Split-Thickness Skin Grafting and Postoperative Radiotherapy
SO DERMATOLOGIC SURGERY
LA English
DT Article
ID EXCISION; RECONSTRUCTION; DEFECTS; THERAPY; PART
AB BACKGROUND The treatment of chest "lock" keloids is challenging due to skin defects and a high recurrence rate.
   OBJECTIVE Evaluation of the effectiveness of autologous split-thickness skin graft with local radiotherapy for treating chest "lock" keloids.
   METHODS AND MATERIALS Fifty-seven patients with chest "lock" keloids were treated from July 2018 to September 2020. The skin defects were closed with an autologous split-thickness skin graft (STSG) and vacuum sealing drainage. The donor and the recipient sites received the first session of radiotherapy 72 hours postoperation for 3 consecutive days. Patients underwent follow-up examinations 12 months after surgery. The Patient and Observer Scar Assessment Scale (POSAS) was used to assess the treatment outcome.
   RESULTS Except for the complaints of pain, which did not improve in the patients' assessments (p = .368), POSAS improved significantly after treatment (p < .0001). The cure rate (including cured and partially cured scars) was 100%. No keloid recurrence was observed during the follow-up period.
   CONCLUSION The procedure of treating chest "lock" keloid by keloid debulking and autologous STSG followed by postoperational radiotherapy is a novel combined methodology for treating keloids.
C1 [Pachuau, Lalrintluangi; Wu, Xiao-Yan; Fu, Mu-Lan; Cui, Xiao-Mei; Chen, Xiao-Dong] Nantong Univ, Dept Dermatol, Affiliated Hosp, Nantong, Jiangsu, Peoples R China.
   [Chen, Xiao-Dong] Nantong Univ, Dept Dermatol, Affiliated Hosp, 20 Xisi St, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University
RP Chen, XD (通讯作者)，Nantong Univ, Dept Dermatol, Affiliated Hosp, 20 Xisi St, Nantong 226001, Jiangsu, Peoples R China.
EM matetelalrintluangi@yahoo.com; wuxiaoyannt@126.com; 709704310@qq.com;
   cxiaomei88@126.com; dermatochen@ntu.edu.cn
CR Ali A, 2021, Mymensingh Med J, V30, P816
   Andrews JP, 2016, MATRIX BIOL, V51, P37, DOI 10.1016/j.matbio.2016.01.013
   Azzam EZ, 2018, J COSMET DERMATOL-US, V17, P502, DOI 10.1111/jocd.12552
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   Brobst B., 2022, STATPEARLS
   Gold MH, 2014, DERMATOL SURG, V40, P825, DOI 10.1111/dsu.0000000000000050
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   Ogawa R, 2015, PLAST RECONSTR SURG, V135, P868, DOI 10.1097/PRS.0000000000000962
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   Shi C, 2018, DERM-ENDOCRINOL, V9, DOI 10.1080/19381980.2018.1448327
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   Xu XY, 2013, INT UROL NEPHROL, V45, P413, DOI 10.1007/s11255-013-0396-0
   Xue ML, 2022, ADV WOUND CARE, V11, P87, DOI 10.1089/wound.2020.1287
   Yi JW, 2015, PLAST RECONSTR SURG, V135, p609E, DOI 10.1097/PRS.0000000000001204
   Yin YC, 2018, INT J SURG, V50, P43, DOI 10.1016/j.ijsu.2017.12.020
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   Zhao Yan-yong, 2003, Zhonghua Zheng Xing Wai Ke Za Zhi, V19, P340
NR 27
TC 6
Z9 6
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-0512
EI 1524-4725
J9 DERMATOL SURG
JI Dermatol. Surg.
PD MAY
PY 2023
VL 49
IS 5S
SU 5
BP S64
EP S69
DI 10.1097/DSS.0000000000003777
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F2AK3
UT WOS:000980422400009
PM 37116003
DA 2026-07-24
ER
PT J
AU Chau, WW
   Lo, KCH
   Lau, LCM
   Ong, MTY
   Ho, KKW
AF Chau, Wai-Wang
   Lo, Kelvin Chin-Hei
   Lau, Lawrence Chun-Man
   Ong, Michael Tim-Yun
   Ho, Kevin Ki-Wai
TI Single use Negative Pressure Wound Therapy (NPWT) system in the
   management of knee arthroplasty
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Negative pressure wound therapy; Length of hospital stay; Skin blister
   formation; BMI
ID VACUUM-ASSISTED CLOSURE; FRACTURE SURGERY; TOTAL HIP; COMPLICATIONS;
   RISK; PREVENTION
AB BackgroundWound complication, skin blister formation in particular, causes devastating consequences after total knee arthroplasty (TKA). Negative Pressure Wound Therapy (NPWT) tries to improve wound management leading to decrease length of hospital stay and better clinical outcomes. Low body mass index (BMI) could play a part in wound recovery management although lacking evidence. This study compared length of hospital stay and clinical outcomes between NPWT and Conventional groups, and factors affected and how BMI affected.MethodsThis was a retrospective clinical record review of 255 (160 NPWT and 95 Conventional) patients between 2018 and 2022. Patient demographics including body mass index (BMI), surgical details (unilateral or bilateral), length of hospital stay, clinical outcomes including skin blisters occurrence, and major wound complications were investigated.ResultsMean age of patients at surgery was 69.95 (66.3% were female). Patients treated with NPWT stayed significantly longer in the hospital after joint replacement (5.18 days vs. 4.55 days; p = 0.01). Significantly fewer patients treated with NPWT found to have blisters (No blisters: 95.0% vs. 87.4%; p = 0.05). In patients with BMI < 30, percentage of patients requiring dressing change was significantly lower when treated with NPWT than conventional (0.8% vs. 33.3%).ConclusionPercentage of blisters occurrence in patients who underwent joint replacement surgery is significantly lower using NPWT. Patients using NPWT stayed significantly longer in the hospital after surgery because significant proportion received bilateral surgery. NPWT patients with BMI < 30 were significantly less likely to change wound dressing.
C1 [Chau, Wai-Wang; Lau, Lawrence Chun-Man; Ong, Michael Tim-Yun] Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China.
   [Lo, Kelvin Chin-Hei] Alice Ho Miu Ling Nethersole Hosp, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China.
   [Ho, Kevin Ki-Wai] Chinese Univ Hong Kong Med Ctr, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Alice Ho Miu Ling Nethersole Hospital
RP Ho, KKW (通讯作者)，Chinese Univ Hong Kong Med Ctr, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China.
EM kevinho@cuhk.edu.hk
RI Ong, Michael Tim Yun/ADU-9207-2022; Ho, Kevin Ki Wai/J-7703-2018; Chau,
   Wai Wang/J-7907-2018; Lau, Lawrence Chun Man/AAJ-4908-2020
OI Ong, Michael Tim Yun/0000-0002-4460-9286; Ho, Kevin Ki
   Wai/0000-0001-8647-8475; Chau, Wai Wang/0000-0002-6973-1915; Lau,
   Lawrence Chun Man/0000-0002-2245-9627
CR Adelani MA, 2014, BONE JOINT J, V96B, P619, DOI 10.1302/0301-620X.96B5.33479
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NR 35
TC 2
Z9 3
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD MAY 5
PY 2023
VL 24
IS 1
AR 351
DI 10.1186/s12891-023-06470-2
PG 11
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA F6DK5
UT WOS:000983227800004
PM 37147702
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Shimbo, K
   Saiki, T
   Kawamoto, H
   Koshima, I
AF Shimbo, Keisuke
   Saiki, Tatsuhiko
   Kawamoto, Haruka
   Koshima, Isao
TI Implant Salvage in Patients With Severe Post-Fracture Fixation Surgical
   Site Infection Using Negative Pressure Wound Therapy With Intramedullary
   and Subcutaneous Antibiotic Perfusion
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE surgical site infection; negative pressure wound therapy; negative
   pressure wound therapy with instillation and dwell time; intramedullary
   antibiotic perfusion; subcutaneous antibiotic perfusion; hardware
   salvage
ID ORTHOPEDIC IMPLANTS; INSTILLATION; PROPHYLAXIS; REMOVAL; BEADS
AB Introduction. Post-fracture fixation surgical site infection (SSI) is a devastating complication, and the standard-of-care therapeutic regimen is ineffective in managing it. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) can be used to salvage orthopedic fixation hardware in the setting of infection; moreover, NPWTi- d can be used effectively in the management of superficial post-fracture fixation SSI. Case Report. Two cases were treated with NPWTi-d. Because of difficulties disrupting the deep dead space biofilm in a deep post-fracture fixation SSI (and because of the risk for bone infection), a doublelumen tube was used for subcutaneous antibiotic perfusion and dead space suction drainage, and bone marrow needles were used for intramedullary antibiotic perfusion to manage or prevent early osteomyelitis. The 2 patients with severe SSI after below-knee fracture fixation were treated with continuous intramedullary and subcutaneous antibiotic perfusion with NPWT to salvage the orthopedic implant. The debrided wounds of the lower leg and heel were reconstructed with free flaps and incisional NPWT, followed by administration of continuous intramedullary and subcutaneous antibiotic perfusion to preserve the titanium plates. In both patients, the wounds healed without complications and remained healed after more than 7 months. Conclusions. Continuous local antibiotic perfusion around infected orthopedic fixation hardware can be an ideal treatment for patients with SSI after fracture fixation. Although this technique can be improved further, it is more effective than conventional therapy in the management of severe post-fracture fixation SSI with a dead space.
C1 [Shimbo, Keisuke; Saiki, Tatsuhiko; Kawamoto, Haruka] Hiroshima Prefectural Hosp, Hiroshima Byoin, Hiroshima, Japan.
   [Koshima, Isao] Hiroshima Univ Hosp, Int Ctr Lymphedema, Hiroshima Daigaku Byoin, Hiroshima, Japan.
C3 Hiroshima University
RP Shimbo, K (通讯作者)，5-54 Ujinakanda, Hiroshima, Hiroshima 7348530, Japan.
EM k_s08_10hyogo@hotmail.com
RI Shimbo, Keisuke/AFN-9685-2022
OI Shimbo, Keisuke/0000-0003-0761-4147
CR Anagnostakos K, 2009, ACTA ORTHOP, V80, P193, DOI 10.3109/17453670902884700
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NR 16
TC 0
Z9 0
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2022
VL 34
IS 6
BP E47
EP E50
DI 10.25270/wnds/21098
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F6QY9
UT WOS:000983583600002
DA 2026-07-24
ER
PT J
AU Mello, DF
AF Mello, Daniel Francisco
TI Dermal Regeneration Matrix in the Treatment of Acute Complex Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE acute complex wounds; artificial skin; dermal regeneration matrix; skin
   graft
ID MATRIDERM(R) 1 MM; RECONSTRUCTIVE SURGERY; NEGATIVE-PRESSURE;
   LOWER-EXTREMITIES; SKIN-GRAFT; BURNS; SUBSTITUTION; INTEGRA(R); DEFECTS
AB Introduction. Dermal regeneration matrices (DRMs) represent a significant advance in wound treatment, but their use remains limited because of high associated costs. Used correctly, DRMs help improve aesthetic and functional results of skin-grafted areas. Objective. This case series reports the use of a DRM of 1-mm and 2-mm thickness in the management of acute complex wounds. Materials and Methods. This is a retrospective analysis of a cohort of patients treated between 2015 and 2018. Complex wounds were defined as those with extensive loss of skin and subcutaneous tissue, or as those in critical areas, that required sequential and specialized treatment. Management of acute wounds involved debridement of devitalized tissue, wound bed preparation, DRM implantation, and split-thickness skin grafting (STSG). Negative pressure wound therapy (NPWT) was used in all cases preoperatively, after DRM implantation, and after STSG. Results of integration of DRM and skin grafts were subjectively evaluated. The Vancouver Scar Scale was used to evaluate results 12 months postoperatively. Results. Traumatic injuries were the most common etiology, and the extension of the treated wounds varied between 4 cm x 5 cm to 42 cm x 28 cm, in the greatest dimensions. A 2-mm-thick matrix was used in 14 cases, with skin grafting after 7 to 9 days. In 6 cases, a 1-mm-thick matrix was used, immediately followed by skin grafting. Negative pressure wound therapy was used in all cases. Dermal regeneration matrices and skin graft integration rates of almost 100% were achieved in all cases. No complications occurred. Conclusions. The results showed use of DRM and NPWT was a good reconstructive option in the management of acute complex wounds that required STSG. With proper patient selection, such treatment is an important tool in the armamentarium of reconstructive procedures.
C1 [Mello, Daniel Francisco] Hosp Rede DOr Sao Luiz, Itaim Unit, Plast Surg, Sao Paulo, Brazil.
RP Mello, DF (通讯作者)，Vivater Clin, Dr Alceu C Rodrigues St 247, BR-04244000 Sao Paulo, Brazil.
EM mello.plastica@gmail.com
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NR 22
TC 0
Z9 0
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2022
VL 34
IS 6
BP 154
EP 158
DI 10.25270/wnds/2022.154158
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F6QY9
UT WOS:000983583600003
DA 2026-07-24
ER
PT J
AU Allen, D
   Robinson, T
   Schmidt, M
   Kieswetter, K
AF Allen, Diwi
   Robinson, Timothy
   Schmidt, Marisa
   Kieswetter, Kristine
TI Preclinical assessment of novel longer-duration wear negative pressure
   wound therapy dressing in a porcine model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE dressing peel force; epithelialization; granulation; negative pressure
   therapy; negative pressure wound therapy; NPT; NPWT; peel and place
   dressing; porcine model; wound healing; wounds
ID VACUUM-ASSISTED CLOSURE; PAIN
AB While reticulated open cell foam (ROCF) is a well-established dressing for negative pressure wound therapy (NPWT), there is the known potential for granulation tissue ingrowth if left in place for longer than 72 h. This may cause wound bed disruption, bleeding, and pain upon dressing removal. In addition, any retained foam fragments may elicit an adverse tissue reaction. A novel, easy to use dressing designed to utilise the advantages of ROCF while addressing its challenges has recently been created. This 7 day study investigated the utility of a novel NPWT dressing under longer-duration wear circumstances while assessing the prevalence of tissue ingrowth and ease of dressing removal in full-thickness excisional wounds utilising a porcine model. Histopathology and morphometry evaluations indicated thicker granulation tissue with, depending on the parameters assessed, either comparable or better tissue quality for wounds treated with the novel dressing. Greater re-epithelialization levels were also evident compared with ROCF. Three-dimensional imaging analysis indicated faster wound fill with a corresponding decrease in wound area with the novel dressing. Furthermore, tissue ingrowth was limited to only ROCF-treated wounds, which was not unexpected in this longer-duration wear study. The force required to remove the novel dressing was considerably lower compared with ROCF, correlating to the tissue ingrowth results. Results of this study illustrate that the novel dressing provided more favourable wound healing results compared with traditional ROCF. In addition, reduction in the risk of tissue ingrowth and low dressing peel force may allow it to be used as a longer-wear dressing.
C1 [Allen, Diwi; Robinson, Timothy; Schmidt, Marisa; Kieswetter, Kristine] 3M Co, Med Solut Div, San Antonio, TX USA.
   [Allen, Diwi] 6203 Farinon Dr, San Antonio, TX 78249 USA.
C3 3M
RP Allen, D (通讯作者)，6203 Farinon Dr, San Antonio, TX 78249 USA.
EM dlallen@mmm.com
FU 3M
FX 3M
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NR 19
TC 7
Z9 8
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY
PY 2023
VL 31
IS 3
BP 349
EP 359
DI 10.1111/wrr.13084
EA MAY 2023
PG 11
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA K5JU9
UT WOS:000985654300001
PM 37074154
OA Bronze
DA 2026-07-24
ER
PT J
AU Qiu, XT
   Sun, XW
   Huang, GB
AF Qiu, Xiaotong
   Sun, Xingwang
   Huang, Guobao
TI Immediate flap increases patient safety for deep sternal wound
   infection: A meta-analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE deep sternal wound infection; flap surgery; length of stay; mortality;
   negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAPS; MEDIASTINITIS; MANAGEMENT
AB Deep sternal wound infection is a severe complication after cardiac surgery. We performed a meta-analysis evaluating the impact of immediate flap and NPWT on mortality and length of hospital stay. The meta-analysis was registered (CRD42022351755). A systematic literature search was conducted from inception to January, 2023, including PubMed, EMBASE, Cochrane Library, and EU Clinical Trials Register. The main outcome were in-hospital mortality and late mortality. And additional outcomes were length of stay and ICU stay time. A total of 438 patients (Immediate flap: 229; NPWT: 209) from four studies were included in this study. Immediate flap was associated with lower in-hospital mortality (OR 0.33, 95% CI 0.13-0.81, P = .02) and length of stay (SMD -13.24, 95% CI -20.53 to -5.94, P = .0004). Moreover, pooled analysis demonstrated no significant difference was found in two groups in terms of late mortality (OR 0.64, 95% CI 0.35-1.16, P = .14) and ICU stay time (SMD -1.65, 95% CI -4.13 to 0.83, P = .19). Immediate flap could reduce in-hospital mortality and length of stay for patients with deep sternal wound infection. Flap transplantation as soon as possible may be advised.
C1 [Qiu, Xiaotong; Sun, Xingwang] Weifang Med Univ, Affiliated Hosp, Sch Clin Med, Weifang, Peoples R China.
   [Qiu, Xiaotong; Huang, Guobao] Jinan Cent Hosp, Dept Burns & Plast Surg, Jinan, Peoples R China.
   [Huang, Guobao] Shandong First Med Univ, Dept Burns & Plast Surg, Cent Hosp, Jinan, Peoples R China.
   [Huang, Guobao] Shandong First Med Univ, Dept Burns & Plast Surg, Cent Hosp, 105 Jiefang Rd, Jinan 250013, Peoples R China.
C3 Shandong Second Medical University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong First Medical University
   & Shandong Academy of Medical Sciences; Shandong First Medical
   University & Shandong Academy of Medical Sciences
RP Huang, GB (通讯作者)，Shandong First Med Univ, Dept Burns & Plast Surg, Cent Hosp, 105 Jiefang Rd, Jinan 250013, Peoples R China.
EM huangguobao@163.com
RI ; Qiu, Xiaotong/HMD-6765-2023
OI 邱, 晓彤/0000-0001-8383-7436; Huang, Guobao/0000-0001-8145-3316; Huang,
   Guobao/0000-0002-5457-9498; 孙, 兴旺/0000-0002-2269-7449; 
FU Shandong First Medical University Youth Science Foundation Training
   Funding Program [202201-130] Funding Source: Medline
CR Arsalan-Werner A, 2020, J PLAST SURG HAND SU, V54, P182, DOI 10.1080/2000656X.2020.1738240
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NR 25
TC 3
Z9 5
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2023
VL 20
IS 8
BP 3271
EP 3278
DI 10.1111/iwj.14207
EA MAY 2023
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S0FS0
UT WOS:000985751300001
PM 37178031
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Marouf, A
   Mortada, H
   Khedr, B
   Halawani, L
   Alarki, SMKZ
   Alghamdi, H
AF Marouf, Azmi
   Mortada, Hatan
   Khedr, Banan
   Halawani, Lamis
   Alarki, Subhi M. K. Zino
   Alghamdi, Hisham
TI Effectiveness and safety of immediate application of negative pressure
   wound therapy in head and neck free flap reconstruction: a systematic
   review
SO BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
LA English
DT Review
DE Free flap; Head and neck; Negative pressure wound therapy; VAC
ID VACUUM-ASSISTED CLOSURE; IMPLANTABLE DOPPLER PROBE; COMPLICATIONS
AB To our knowledge this is the first systematic review of the immediate application of negative pressure wound therapy (NPWT) to the head and neck in free flap reconstruction. We conducted a systematic search of the PubMed and Cochrane databases in October 2021 using the MeSH terms 'negative pressure wound therapy', 'free flaps', 'microsurgery', and 'vacuum-assisted closure'. Included studies evaluated the use of immediate NPWT in head and neck free flap reconstruction. Outcomes, indications, monitoring, and reported complications were retrieved. Of the 908 articles searched, nine published between 2000 and 2021 were included: four retrospective studies and five case series. NPWT was applied to 56 free flaps, and 54 had successful outcomes. The most common reported indication for flap reconstruction was malignancy. NPWT has the potential to be a valuable tool for complicated wounds, and further studies are needed to quantify functional and aesthetic outcomes.(c) 2022 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Marouf, Azmi] Case Western Reserve Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Cleveland Hts, OH 44106 USA.
   [Marouf, Azmi] Univ Hosp Cleveland Med Ctr, Cleveland Hts, OH 44106 USA.
   [Mortada, Hatan] King Saud Univ, King Saud Univ Med City, Dept Surg, Div Plast Surg, Riyadh, Saudi Arabia.
   [Mortada, Hatan] King Saud Med City, Dept Plast Surg & Burnunit, Riyadh, Saudi Arabia.
   [Khedr, Banan] Princess Nora Bint Abdulrahman Univ, King Abdullah Bin Abdulaziz Univ Hosp, Div Plast Surg, Riyadh, Saudi Arabia.
   [Halawani, Lamis] King Fahad Armed Forces Hosp, Div Otorhinolaryngol Head & Neck Surg, Jeddah, Saudi Arabia.
   [Alarki, Subhi M. K. Zino; Alghamdi, Hisham] King Saud Univ, King Saud Univ Med City, Dept Surg, Div Plast Surg, Riyadh, Saudi Arabia.
C3 University System of Ohio; Case Western Reserve University; University
   Hospitals of Cleveland; King Saud University; King Saud Medical City;
   Princess Nourah bint Abdulrahman University; King Fahd Armed Forces
   Hospital; King Saud University
RP Marouf, A (通讯作者)，Case Western Reserve Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Cleveland Hts, OH 44106 USA.
EM axm1676@case.edu
RI ; Alarki, Subhi/OVZ-7517-2025; Mortada, Hatan/IZE-0947-2023
OI Marouf, Azmi/0000-0002-2267-9873; 
CR Asher SA, 2014, JAMA OTOLARYNGOL, V140, P143, DOI 10.1001/jamaoto.2013.6143
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NR 37
TC 9
Z9 12
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0266-4356
EI 1532-1940
J9 BRIT J ORAL MAX SURG
JI Br. J. Oral Maxillofac. Surg.
PD OCT
PY 2022
VL 60
IS 8
BP 1005
EP 1011
DI 10.1016/j.bjoms.2022.04.003
EA OCT 2022
PG 7
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA G1MS2
UT WOS:000986887600004
PM 35690503
DA 2026-07-24
ER
PT J
AU Seidelman, JL
   Mantyh, CR
   Anderson, DJ
AF Seidelman, Jessica L.
   Mantyh, Christopher R.
   Anderson, Deverick J.
TI Surgical Site Infection Prevention A Review
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Review
ID PROSTHETIC JOINT INFECTION; STAPHYLOCOCCUS-AUREUS; SAFETY CHECKLIST;
   RISK-FACTOR; ANTIMICROBIAL-PROPHYLAXIS; CARDIOTHORACIC SURGERY;
   COLORECTAL SURGERY; WOUND-INFECTION; UNITED-STATES; CONTAMINATION
AB ImportanceApproximately 0.5% to 3% of patients undergoing surgery will experience infection at or adjacent to the surgical incision site. Compared with patients undergoing surgery who do not have a surgical site infection, those with a surgical site infection are hospitalized approximately 7 to 11 days longer.ObservationsMost surgical site infections can be prevented if appropriate strategies are implemented. These infections are typically caused when bacteria from the patient's endogenous flora are inoculated into the surgical site at the time of surgery. Development of an infection depends on various factors such as the health of the patient's immune system, presence of foreign material, degree of bacterial wound contamination, and use of antibiotic prophylaxis. Although numerous strategies are recommended by international organizations to decrease surgical site infection, only 6 general strategies are supported by randomized trials. Interventions that are associated with lower rates of infection include avoiding razors for hair removal (4.4% with razors vs 2.5% with clippers); decolonization with intranasal antistaphylococcal agents and antistaphylococcal skin antiseptics for high-risk procedures (0.8% with decolonization vs 2% without); use of chlorhexidine gluconate and alcohol-based skin preparation (4.0% with chlorhexidine gluconate plus alcohol vs 6.5% with povidone iodine plus alcohol); maintaining normothermia with active warming such as warmed intravenous fluids, skin warming, and warm forced air to keep the body temperature warmer than 36 degrees C (4.7% with active warming vs 13% without); perioperative glycemic control (9.4% with glucose 150 mg/dL); and use of negative pressure wound therapy (9.7% with vs 15% without). Guidelines recommend appropriate dosing, timing, and choice of preoperative parenteral antimicrobial prophylaxis.Conclusions and RelevanceSurgical site infections affect approximately 0.5% to 3% of patients undergoing surgery and are associated with longer hospital stays than patients with no surgical site infections. Avoiding razors for hair removal, maintaining normothermia, use of chlorhexidine gluconate plus alcohol-based skin preparation agents, decolonization with intranasal antistaphylococcal agents and antistaphylococcal skin antiseptics for high-risk procedures, controlling for perioperative glucose concentrations, and using negative pressure wound therapy can reduce the rate of surgical site infections.
C1 [Seidelman, Jessica L.; Anderson, Deverick J.] Duke Univ Sch Med, Duke Ctr Antimicrobial Stewardship & Infect Preven, Durham, NC USA.
   [Mantyh, Christopher R.] Duke Univ Sch Med, Dept Surg, Durham, NC USA.
   [Anderson, Deverick J.] Box 102359, Durham, NC 27710 USA.
C3 Duke University; Duke University
RP Anderson, DJ (通讯作者)，Box 102359, Durham, NC 27710 USA.
EM deverick.anderson@duke.edu
RI mantyh, christopher/AAJ-9140-2021
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NR 83
TC 394
Z9 488
U1 26
U2 162
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JAN 17
PY 2023
VL 329
IS 3
BP 244
EP 252
DI 10.1001/jama.2022.24075
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA G3PQ9
UT WOS:000988321100016
PM 36648463
HC Y
HP N
DA 2026-07-24
ER
PT J
AU Forrester, JD
   Faliks, B
   Cardarelli, C
   Choudhry, MS
   Patel, B
   Ricaurte, D
   Sarani, B
   Sfakianos, M
   Kartiko, S
   Huston, JM
AF Forrester, Joseph D.
   Faliks, Bradley
   Cardarelli, Cassandra
   Choudhry, Muhammad Saad
   Patel, Bhavik
   Ricaurte, Daniel
   Sarani, Babak
   Sfakianos, Maria
   Kartiko, Susan
   Huston, Jared M.
TI Chest Wall Injury Society Recommendations for Management of Surgical
   Site or Implant-Related Infections After Surgical Stabilization of
   Traumatic Rib or Sternal Fractures
SO SURGICAL INFECTIONS
LA English
DT Article
DE antibiotic agents; implant; infection; rib fractures; surgery; trauma
ID QUALITY-OF-LIFE; FLAIL CHEST; INTERNAL-FIXATION; HARDWARE; OUTCOMES;
   PAIN
AB Background: Surgical stabilization of rib fractures (SSRF) and surgical stabilization of sternal fractures (SSSF) involves open reduction and internal fixation of fractures with an implantable titanium plate to restore and maintain anatomic alignment. The presence of this foreign, non-absorbable material presents an opportunity for infection. Although surgical site infection (SSI) and implant infection rates after SSRF and SSSF are low, they present a challenging clinical entity.Methods: The Surgical Infection Society's Therapeutics and Guidelines Committee and Chest Wall Injury Society's Publication Committee convened to develop recommendations for management of SSIs or implant-related infections after SSRF or SSSF. PubMed, Embase, Web of Science and the Cochrane database were searched for pertinent studies. Using a process of iterative consensus, all committee members voted to accept or reject each recommendation.Results: For patients undergoing SSRF or SSSF who develop an SSI or an implant-related infection, there is insufficient evidence to suggest a single optimal management strategy. For patients with an SSI, systemic antibiotic therapy, local wound debridement, and vacuum-assisted closure have been used in isolation or combination. For patients with an implant-related infection, initial implant removal with or without systemic antibiotic therapy, systemic antibiotic therapy with local wound drainage, and systemic antibiotic therapy with local antibiotic therapy have been documented. For patients who do not undergo initial implant removal, 68% ultimately require implant removal to achieve source control.Conclusions: Insufficient evidence precludes the ability to recommend guidelines for the treatment of SSI or implant-related infection following SSRF or SSSF. Further studies should be performed to identify the optimal management strategy in this population.
C1 [Forrester, Joseph D.; Cardarelli, Cassandra] Stanford Univ, Dept Surg, Div Gen Surg, Stanford, CA USA.
   [Faliks, Bradley] HonorHlth Scottsdale Osborn Med Ctr, Dept Surg, Phoenix, AZ USA.
   [Choudhry, Muhammad Saad] Dow Univ Hlth Sci, Dept Surg, Karachi, Pakistan.
   [Patel, Bhavik] Gold Coast Univ Hosp, Div Trauma, Southport, Qld, Australia.
   [Ricaurte, Daniel] Hartford Hosp, Dept Acute Care Surg, Hartford, CT USA.
   [Sarani, Babak; Kartiko, Susan] George Washington Univ, Dept Surg, Ctr Trauma & Crit Care, Sch Med & Hlth Sci, Washington, DC USA.
   [Sfakianos, Maria; Huston, Jared M.] Zucker Sch Med Hofstra Northwell, Dept Surg, Div Trauma & Acute Care Surg, Hempstead, NY USA.
   [Sarani, Babak; Kartiko, Susan] Zucker Sch Med Hofstra Northwell, Dept Sci Educ, Div Trauma & Acute Care Surg, Hempstead, NY USA.
   [Forrester, Joseph D.] Stanford Univ, Dept Surg, Div Gen Surg, H3591,300 Pasteur Dr, Stanford, CA 94305 USA.
C3 Stanford University; Scottsdale Healthcare Osborn; Dow University of
   Health Sciences; Gold Coast University Hospital; Hartford Hospital;
   George Washington University; Northwell Health; Northwell Health;
   Stanford University; Stanford Medicine
RP Forrester, JD (通讯作者)，Stanford Univ, Dept Surg, Div Gen Surg, H3591,300 Pasteur Dr, Stanford, CA 94305 USA.
EM jdf1@stanford.edu
RI Faliks, Brad/NBW-8002-2025; Choudhry, Muhammad Saad/HZL-9283-2023
OI Forrester, Joseph/0000-0002-8558-6180
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NR 43
TC 3
Z9 4
U1 1
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD JUN 1
PY 2023
VL 24
IS 5
BP 414
EP 424
DI 10.1089/sur.2023.086
EA MAY 2023
PG 11
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA I3SW8
UT WOS:000989557100001
PM 37204325
DA 2026-07-24
ER
PT J
AU Zhang, YL
   Tian, SW
   Liu, MY
   Zhai, WF
   Zhou, YJ
   Peng, AQ
AF Zhang, Yanlong
   Tian, Shuwei
   Liu, Meiyu
   Zhai, Wenfang
   Zhou, Yujie
   Peng, Aqin
TI Comparison of antibiotic-impregnated bone cement coverage versus vacuum
   sealing drainage in semi-open bone grafting using for tibial fracture
   with infected bone and soft tissue defect: a retrospective analysis
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Tibial fracture; Infected bone defect; Soft tissue defect; Semiopen bone
   grafting; Bone cement
ID INDUCED MEMBRANE; TRANSPORT
AB Objective To compare antibiotic-impregnated bone cement coverage (bone cement surface technique; BCS-T) versus vacuum sealing drainage (VSD) for tibial fracture with infected bone and soft tissue defect.
   Method This retrospective analysis compared the clinical outcomes in patients undergoing BCS-T (n = 16) versus VSD (n = 15) for tibial fracture with infected bone and soft tissue defect at the Third Hospital of Hebei Medical University from March 2014 to August 2019. For BCS-T group, osseous cavity was filled with autograft bone graft after debridement, and then the wound was covered with a 3-mm layer of bone cement impregnated with vancomycin and gentamycin. The dressing was changed every day in the first week, and every 2 similar to 3 days in the second week. For VSD group, a negative pressure of -150 similar to -350 mmHg was maintained, and the dressing was changed every 5-7 days. All patients received antibiotics treatment based on bacterial culture results for 2 weeks.
   Results The 2 groups did not differ in age, sex and key baseline characteristics, including type of Gustilo-Anderson classification, size of the bone and soft tissue defect, the percentage of primary debridement, bone transport, and the time from injury to bone grafting. The median follow-up was 18.9 months (range:12-40). The time to complete coverage of bone graft by granulation tissue was 21.2 (15.0-44.0) and 20.3 (15.0-24.0) days in the BCS-T and VSD groups, respectively (p = 0.412). The 2 groups also did not differ in wound healing time (3.3 (1.5-5.5) versus 3.2(1.5-6.5) months; p = 0.229) and bone defect healing time (5.4(3.0-9.6) versus 5.9(3.2-11.5) months; p = 0.402). However, the cost of covering material was significantly reduced in the BCS-T group (2071 +/- 134 versus 5542 +/- 905 yuan; p = 0.026). Paley functional classification at 12 months did not differ between the 2 groups (excellent in 87.5% versus 93.3% in the 2 groups; p = 0.306).
   Conclusion BCS-T could achieve clinical outcomes similar to VSD in patients receiving bone graft for tibial fracture with infected bone and soft tissue defect, but material cost was significantly reduced. Randomized controlled trials are needed to verify our finding.
C1 [Zhang, Yanlong; Zhou, Yujie] Hebei Med Univ, Trauma Ctr, Hosp 1, Shijiazhuang 050031, Hebei, Peoples R China.
   [Tian, Shuwei] Hebei Prov Gen Hosp, Shijiazhuang 050057, Hebei, Peoples R China.
   [Liu, Meiyu] Hebei Med Univ, Hosp 2, Shijiazhuang 050051, Hebei, Peoples R China.
   [Zhai, Wenfang; Peng, Aqin] Hebei Med Univ, Dept Orthopaed, Hosp 3, Shijiazhuang 050051, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University; Hebei Medical
   University
RP Peng, AQ (通讯作者)，Hebei Med Univ, Dept Orthopaed, Hosp 3, Shijiazhuang 050051, Hebei, Peoples R China.
EM pengaqin@126.com
RI /AAM-8825-2020
FU Science and Technology Plan Program of Hebei Province [14277745D,
   14277745D, 14277745D] Funding Source: Medline; Key Research and
   Development Program of Hebei Province [No. 20377744D, No. 20377744D, No.
   20377744D] Funding Source: Medline
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NR 23
TC 3
Z9 6
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD MAY 19
PY 2023
VL 24
IS 1
AR 401
DI 10.1186/s12891-023-06475-x
PG 7
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA G6BG3
UT WOS:000989981900002
PM 37208629
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Whitty, JA
   Wagner, AP
   Kang, EVY
   Ellwood, D
   Chaboyer, W
   Kumar, S
   Clifton, VL
   Thalib, L
   Gillespie, BM
AF Whitty, Jennifer A.
   Wagner, Adam P.
   Kang, Evelyn
   Ellwood, David
   Chaboyer, Wendy
   Kumar, Sailesh
   Clifton, Vicki L.
   Thalib, Lukman
   Gillespie, Brigid M.
TI Cost-effectiveness of closed incision negative pressure wound therapy in
   preventing surgical site infection among obese women giving birth by
   caesarean section: An economic evaluation (DRESSING trial)
SO AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
LA English
DT Article
DE caesarean section; cost-effectiveness; economic evaluation; negative
   pressure wound therapy; surgical site infection
ID MANAGEMENT; HEALTH
AB BackgroundThere is growing evidence regarding the potential of closed incision negative pressure wound therapy (ci-NPWT) to prevent surgical site infections (SSIs) in healing wounds by primary closure following a caesarean section (CS). AimTo assess the cost-effectiveness of ci-NPWT compared to standard dressings for prevention of SSI in obese women giving birth by CS. Materials and MethodsCost-effectiveness and cost-utility analyses from a health service perspective were undertaken alongside a multicentre pragmatic randomised controlled trial, which recruited women with a pre-pregnancy body mass index >= 30 kg/m(2) giving birth by elective/semi-urgent CS who received ci-NPWT (n = 1017) or standard dressings (n = 1018). Resource use and health-related quality of life (SF-12v2) collected during admission and for four weeks post-discharge were used to derive costs and quality-adjusted life years (QALYs). Resultsci-NPWT was associated with AUD$162 (95%CI -$170 to $494) higher cost per person and an additional $12 849 (95%CI -$62 138 to $133 378) per SSI avoided. There was no detectable difference in QALYs between groups; however, there are high levels of uncertainty around both cost and QALY estimates. There is a 20% likelihood that ci-NPWT would be considered cost-effective at a willingness-to-pay threshold of $50 000 per QALY. Per protocol and complete case analyses gave similar results, suggesting that findings are robust to protocol deviators and adjustments for missing data. Conclusionsci-NPWT for the prevention of SSI in obese women undergoing CS is unlikely to be cost-effective in terms of health service resources and is currently unjustified for routine use for this purpose.
C1 [Whitty, Jennifer A.; Wagner, Adam P.] Univ East Anglia, Norwich Med Sch, Norwich, England.
   [Whitty, Jennifer A.; Wagner, Adam P.] NIHR Appl Res Collaborat ARC East England EoE, Natl Inst Hlth Res, Cambridge, England.
   [Kang, Evelyn; Chaboyer, Wendy; Gillespie, Brigid M.] Griffith Univ, Menzies Hlth Inst, Natl Hlth & Med Res Council Ctr Res Excellence Wis, Gold Coast, Qld, Australia.
   [Ellwood, David; Gillespie, Brigid M.] Gold Coast Univ Hosp, Gold Coast Hlth, Southport, Qld, Australia.
   [Ellwood, David] Griffith Univ, Sch Med & Dent, Gold Coast, Qld, Australia.
   [Kumar, Sailesh] Univ Queensland, Mater Mothers Hosp, Brisbane, Qld, Australia.
   [Clifton, Vicki L.] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
   [Thalib, Lukman] Istanbul Aydin Univ, Fac Med, Dept Biostat, Istanbul, Turkiye.
   [Whitty, Jennifer A.] Evidera, Ark, 2nd floor,201 Talgarth Rd, London W6 8BJ, England.
C3 University of East Anglia; University of Cambridge; Menzies Health
   Institute Queensland; Griffith University; Gold Coast University
   Hospital; Gold Coast Health; Griffith University; University of
   Queensland; Mater Health Services; Mater Mothers' Hospital; University
   of Queensland; Mater Research; Istanbul Aydin University; Evidera
RP Whitty, JA (通讯作者)，Evidera, Ark, 2nd floor,201 Talgarth Rd, London W6 8BJ, England.
EM jenny.whitty@evidera.com
RI Clifton, Vicki L/AAV-2749-2021; Kumar, Sailesh/M-3207-2014; Ellwood,
   David/C-8208-2015; Chaboyer, Wendy/F-9588-2018; Wagner,
   Adam/AAA-4346-2019; Gillespie, Brigid/E-7799-2012; Thalib,
   Lukman/HAI-7553-2022; Whitty, Jennifer/N-6434-2013
OI Clifton, Vicki L/0000-0002-4892-6748; Kumar,
   Sailesh/0000-0003-0832-4811; Ellwood, David/0000-0003-4512-6443;
   Chaboyer, Wendy/0000-0001-9528-7814; Wagner, Adam/0000-0002-9101-3477;
   Gillespie, Brigid/0000-0003-3186-5691; Thalib,
   Lukman/0000-0002-1211-6495; Whitty, Jennifer/0000-0002-5886-1933
FU Australian National Health and Medical Research Council [APP1081026];
   United Kingdom's (UK's) National Institute of Health Research (NIHR)
   Applied Research Collaboration East of England (ARC EoE) program
FX We thank all the women who took part, the wider research team, and staff
   members involved in the trial at the recruitment sites. The trial was
   funded by the competitive peer-reviewed grant (APP1081026) from the
   Australian National Health and Medical Research Council. Jennifer Whitty
   and Adam Wagner are supported by the United Kingdom's (UK's) National
   Institute of Health Research (NIHR) Applied Research Collaboration East
   of England (ARC EoE) program. The views expressed are those of the
   authors and not necessarily those of the UK's National Health Service
   (NHS), NIHR or Department of Health and Social Care.
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   Malmsjo Malin, 2014, Eplasty, V14, pe15
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   National Institute for Health and Care Excellence, 2013, GUID METH TECHN APPR
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   Scalise A, 2016, INT WOUND J, V13, P1260, DOI 10.1111/iwj.12492
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NR 29
TC 7
Z9 7
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0004-8666
EI 1479-828X
J9 AUST NZ J OBSTET GYN
JI Aust. N. Z. J. Obstet. Gynaecol.
PD OCT
PY 2023
VL 63
IS 5
BP 673
EP 680
DI 10.1111/ajo.13677
EA MAY 2023
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA X4MP0
UT WOS:000990232600001
PM 37200473
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Munro, SP
   Dearden, A
   Joseph, M
   O'Donoghue, JM
AF Munro, S. P.
   Dearden, A.
   Joseph, M.
   O'Donoghue, J. M.
TI Reducing donor-site complications in DIEP flap breast reconstruction
   with closed incisional negative pressure therapy: A cost-benefit
   analysis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE ciNPT; Negative pressure; DIEP; PREVENA; Seroma
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; WOUND THERAPY;
   BLOOD-FLOW; METAANALYSIS; IMPACT
AB Introduction: Deep inferior epigastric perforator (DIEP) flaps are considered the gold standard for autologous breast reconstruction but create large abdominal incisions that risk donor-site morbidity during harvest. Closed incision negative pressure therapy (ciNPT) is emerging as an effective alternative to standard postoperative dressings, but there is a paucity of data in DIEP flap donor sites. Methods: We conducted a retrospective case-control study investigating the use of ciNPT in DIEP flap donor sites at a single institution between March 2017 and September 2021. Patients who underwent microsurgical autologous breast reconstruction with DIEP flaps were included. Patients were divided into those with donor incision sites managed with ciNPT (n = 24) and those with conventional postoperative wound dressings (n = 20). We compared patient de-mographics, wound drainage volumes and postoperative outcomes between the two groups. A cost-benefit analysis was employed to compare the overall costs associated with each compli-cation and differences in length of stay between the two groups. Results: There was no statistically significant difference in age, body mass index (BMI), comor-bidity burden or smoking status between the two groups. Both groups had similar lengths of stay and wound drainage volumes with no readmissions or reoperations in either group. There was a statistically significant reduction in donor-site complications (p = 0.018), surgical site infections (p = 0.014) and seroma formation (p = 0.016) in those with ciNPT. Upon cost-benefit analysis, the ciNPT group had a mean reduction in cost-per-patient associated with postoper-ative complications of 420.77 pound (p = 0.031) and 446.47 pound (p = 0.049) when also accounting for postoperative length of stayConclusion: ciNPT appears to be an effective alternative incision management system with the potential to improve complication rates and postoperative morbidity in DIEP flap donor sites. Our analysis demonstrates improved cost-benefit outweighing the increase in costs associated with ciNPT. We recommend a multicentre prospective trial with formal cost-utility analysis to strengthen these findings. (c) 2022 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.
C1 [Munro, S. P.; Dearden, A.; Joseph, M.; O'Donoghue, J. M.] Newcastle Upon Tyne Hosp NHS Fdn Trust, Royal Victoria Infirm, Dept Plast & Reconstruct Surg, Newcastle Upon Tyne NE1, England.
   [Munro, S. P.] Royal Victoria Infirm, Dept Plast Surg, Newcastle Upon Tyne NE1 4LP, England.
C3 Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University
   - UK
RP Munro, SP (通讯作者)，Royal Victoria Infirm, Dept Plast Surg, Newcastle Upon Tyne NE1 4LP, England.
EM samuelpmunro@yahoo.co.uk
OI joseph, martin/0000-0002-9574-1113; Munro, Samuel/0000-0003-0627-9818
CR Abesamis GM, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002141
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NR 25
TC 20
Z9 21
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAR
PY 2023
VL 78
BP 13
EP 18
DI 10.1016/j.bjps.2022.08.003
EA FEB 2023
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA G7TV7
UT WOS:000991147300001
PM 36739647
DA 2026-07-24
ER
PT J
AU Liu, X
   Zhao, XY
   Shen, GL
   Fan, SW
   Xu, J
   Fan, ZJ
   Li, K
AF Liu, Xiao
   Zhao, Xiaoyu
   Shen, Guoliang
   Fan, Shuwen
   Xu, Jun
   Fan, Zhaojun
   Li, Ke
TI Effect of sinus resection combined with vacuum-assisted closure on
   sacrococcygeal pilonidal sinus
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE sacrococcygeal pilonidal sinus; sinus resection; wound vacuum-assisted
   closure
AB This study was aimed at investigating the effect of sinus removal combined with vacuum-assisted closure in the treatment of sacrococcygeal pilonidal sinus. From January 2019 to May 2022, 62 patients with sacrococcygeal pilonidal sinus were treated and their information was collected at our hospital. These patients were randomly divided into two groups: an observation group (n = 32) and a control group (n = 30). The control group underwent a simple sinus resection and suture, while the observation group received a sinus resection combined with closed negative pressure drainage of the wound. A retrospective analysis of the data obtained was conducted. Perioperative indicators, clinical efficacy, postoperative pain, complications, aesthetic effects, and satisfaction scores at six months after the operation were compared between the two groups, and the recurrence rate at six months after the operation was recorded. Through this study, we found that the observation group had significantly shorter surgery time, hospital stay, and return time compared with the control group (P < 0.05). Additionally, the observation group had a higher overall recurrence rate (ORR) of 100.00%, which was significantly better than the control group's ORR of 86.67% (P < 0.05). The visual analog scale (VAS) score at 6, 12, and 24 h after the operation was significantly lower in the observation group compared with the control group (P < 0.05). Although the differences were not significant (P > 0.05), the observation group had decreased white blood cell, neutrophil, and C-reactive protein levels after the operation. Moreover, the total occurrence rate of postoperative complications in the observation group was significantly lower (6.25%) than that of the control group (26.67%; P < 0.05). The observation group also had significantly lower scores on the postoperative scar scale and higher satisfaction scores than the control group (P < 0.05). However, there was no significant difference in the postoperative recurrence rate between the two groups (P > 0.05). Our study demonstrated that sinus resection combined with vacuum-assisted closure was more effective in treating sacrococcygeal pilonidal sinus compared with simple sinus resection and suture. This approach significantly reduced surgery time, hospital stay, and return time. It also effectively relieved postoperative pain, reduced the occurrence of postoperative complications, resulted in smaller postoperative scars, and yielded better aesthetic outcomes and higher patient satisfaction.
C1 [Liu, Xiao; Zhao, Xiaoyu; Shen, Guoliang; Fan, Shuwen; Xu, Jun; Fan, Zhaojun; Li, Ke] Soochow Univ, Affiliated Hosp 1, Dept Burn & Plast Surg, Suzhou, Peoples R China.
   [Li, Ke] Soochow Univ, Affiliated Hosp 1, Dept Burn & Plast Surg, 188 Shizi St, Suzhou 215000, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Li, K (通讯作者)，Soochow Univ, Affiliated Hosp 1, Dept Burn & Plast Surg, 188 Shizi St, Suzhou 215000, Peoples R China.
EM likefggf@163.com
FU Suzhou Science and Technology Plan Projects [SYS2020105]
FX Suzhou Science and Technology Plan Projects, Grant/Award
   Number:SYS2020105
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   Yang YP, 2020, INT WOUND J, V17, P555, DOI 10.1111/iwj.13315
   Yildiz A, 2022, ASIAN J SURG, V45, P381, DOI 10.1016/j.asjsur.2021.06.029
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NR 32
TC 3
Z9 4
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD NOV
PY 2023
VL 20
IS 9
BP 3474
EP 3482
DI 10.1111/iwj.14218
EA MAY 2023
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA X7KJ3
UT WOS:000992295200001
PM 37218401
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kavanagh, F
   Singhal, S
   Rozen, WM
AF Kavanagh, Francene
   Singhal, Shaani
   Rozen, Warren M.
TI Split thickness skin graft compression: a scoping review
SO GLAND SURGERY
LA English
DT Review
DE Split thickness skin graft (STSG); vacuum assisted closure (VAC);
   negative pressure wound therapy (NPWT); lymph node; compression
ID NEGATIVE-PRESSURE DRESSINGS; VACUUM-ASSISTED CLOSURE; DONOR SITE;
   THERAPY; REGION
AB Background: Split thickness skin graft (STSG) is a routine reconstructive manoeuvre, particularly after excision of cutaneous lower limb malignancies. While surgical technique is well established, evidence supporting the postoperative management of these grafts is less robust. Compression therapy after the index procedure may be an important adjunct for graft take and minimizing complications, particularly in patients susceptible to oedema from a concurrent lymph node procedure. Methods: An initial PubMed literature search was performed using the terms "split thickness skin graft", "compression" and "oedema" yielding no results, hence a broader search was performed combining the terms "compression", "pressure" and "split thickness skin graft" providing 383 results. One hundred articles remained for abstract review after an initial screen. Results: The literature on compression therapy to promote split thickness graft take is modest, with only 12 articles described (12/100, 12.0%). Even then, none of these were in the setting of grafting after oncological resection. Many of the articles promote negative pressure wound therapy (NPWT) as an established adjunct to promote graft take (80/100, 80.0%). Conclusions: There is limited demonstrated efficacy of postoperative compression therapy for lower limb STSG let alone in patients with an ancillary lymph node procedure. Further large-scale trials ideally in a prospective fashion are warranted to validate this as a simple, widely available and cost-effective adjunct to STSG in this particularly susceptible population of reconstructive patients.
C1 [Kavanagh, Francene; Singhal, Shaani; Rozen, Warren M.] Monash Univ, Fac Med, Peninsula Clin Sch, Cent Clin Sch,Dept Plast & Reconstruct Surg, Frankston, Australia.
   [Rozen, Warren M.] Monash Univ, Fac Med, Peninsula Clin Sch, Cent Clin Sch,Dept Plast & Reconstruct Surg, 2 Hastings Rd, Frankston, Vic 3199, Australia.
C3 Monash University; Monash University
RP Rozen, WM (通讯作者)，Monash Univ, Fac Med, Peninsula Clin Sch, Cent Clin Sch,Dept Plast & Reconstruct Surg, Frankston, Australia.; Rozen, WM (通讯作者)，Monash Univ, Fac Med, Peninsula Clin Sch, Cent Clin Sch,Dept Plast & Reconstruct Surg, 2 Hastings Rd, Frankston, Vic 3199, Australia.
EM warrenrozen@hotmail.com
RI Rozen, Warren/AAE-6296-2022
CR Achora S, 2014, J WOUND OSTOMY CONT, V41, P335, DOI 10.1097/WON.0000000000000035
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NR 26
TC 3
Z9 3
U1 0
U2 4
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2227-684X
EI 2227-8575
J9 GLAND SURG
JI Gland Surg.
PD FEB
PY 2023
VL 12
IS 2
BP 297
EP 301
DI 10.21037/gs-22-468
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA H0BW4
UT WOS:000992714100007
PM 36915820
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Winstanley, RJH
   Hadfield, JN
   Walker, R
   Bretherton, CP
   Ashwood, N
   Allison, K
   Trompeter, A
   Eardley, WGP
AF Winstanley, R. J. H.
   Hadfield, J. N.
   Walker, R.
   Bretherton, C. P.
   Ashwood, N.
   Allison, K.
   Trompeter, A.
   Eardley, W. G. P.
CA Open-Fracture Patient Evaluation
TI The Open-Fracture Patient Evaluation Nationwide (OPEN) study THE
   MANAGEMENT OF OPEN FRACTURE CARE IN THE UK
SO BONE & JOINT JOURNAL
LA English
DT Article
ID INITIAL MANAGEMENT; WOUND MANAGEMENT; LOWER-LIMB; INFECTION
AB Aims
   The Open-Fracture Patient Evaluation Nationwide (OPEN) study was performed to provide clarity in open fracture management previously skewed by small, specialist centre studies and large, unfocused registry investigations. We report the current management metrics of open fractures across the UK.
   Method
   Patients admitted to hospital with an open fracture (excluding phalanges or isolated hand injuries) between 1 June 2021 and 30 September 2021 were included. Institutional information governance approval was obtained at the lead site and all data entered using Research Electronic Data Capture software. All domains of the British Orthopaedic Association Standard for Open Fracture Management were recorded.
   Results
   Across 51 centres, 1,175 patients were analyzed. Antibiotics were given to 754 (69.0%) in the emergency department, 240 (22.0%) pre-hospital, and 99 (9.1%) as inpatients. Wounds were photographed in 848 (72.7%) cases. Median time to first surgery was 16 hrs 14 mins (interquartile range (IQR) 8 hrs 29 mins to 23 hrs 19 mins). Complex injuries were operated on sooner (median 12 hrs 51 mins (IQR 4 hrs 36 mins to 21 hrs 14 mins)). Of initial procedures, 1,053 (90.3%) occurred between 8am and 8pm. A consultant orthopaedic surgeon was present at 1,039 (89.2%) first procedures. In orthoplastic centres, a consultant plastic surgeon was present at 465 (45.1%) first procedures. Overall, 706 (60.8%) patients required a single operation. At primary debridement, 798 (65.0%) fractures were definitively fixed, while 734 (59.8%) fractures had fixation and coverage in one operation through direct closure or soft-tissue coverage. Negative pressure wound therapy was used in 235 (67.7%) staged procedures. Following wound closure or soft-tissue cover, 509 (47.0%) patients received antibiotics for a median of three days (IQR 1 to 7).
   Conclusion
   OPEN provides an insight into care across the UK and different levels of hospital for open fractures. Patients are predominantly operated on promptly, in working hours, and at specialist centres. Areas for improvement include combined patient review and follow-up, scheduled operating, earlier definitive soft-tissue cover, and more robust antibiotic husbandry.
C1 [Winstanley, R. J. H.; Hadfield, J. N.; Walker, R.; Bretherton, C. P.; Ashwood, N.; Allison, K.; Trompeter, A.; Eardley, W. G. P.] South Tees Hosp NHS Trust, James Cook Univ Hosp, Middlesbrough, Cleveland, England.
C3 James Cook University Hospital
RP Winstanley, RJH (通讯作者)，South Tees Hosp NHS Trust, James Cook Univ Hosp, Middlesbrough, Cleveland, England.
EM robert.winstanley1@nhs.net
RI ; Bretherton, Christopher/LDE-6304-2024; Ashwood, Neil/L-7881-2019;
   Trompeter, Alex/JCD-4455-2023
OI Winstanley, Robert John Henry/0000-0002-5102-8535; Bretherton,
   Christopher/0000-0001-9569-0734; Neo, Chryssa/0000-0002-3143-3007;
   Walker, Reece/0000-0002-7181-4699; Hadfield, James/0000-0001-7052-8036;
   Allison, Keith/0000-0002-2843-4885; Eardley, Will/0000-0003-1980-8520; 
FU AOUK&I Research Grant
FX The authors disclose receipt of the following financial or material
   support for the research, authorship, and/or publication of this
   article: AOUK&I Research Grant.
CR [Anonymous], 2000, TRAUMA AUDIT RES NET
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NR 25
TC 9
Z9 14
U1 1
U2 4
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD SEP
PY 2022
VL 104B
IS 9
BP 1073
EP 1080
DI 10.1302/0301-620X.104B9.BJJ-2022-0202.R1
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA H2EW1
UT WOS:000994158100011
PM 36047016
DA 2026-07-24
ER
PT J
AU Bruce, J
   Knight, R
   Parsons, N
   Betteridge, R
   Verdon, A
   Brown, J
   Campolier, M
   Achten, J
   Costa, ML
AF Bruce, J.
   Knight, R.
   Parsons, N.
   Betteridge, R.
   Verdon, A.
   Brown, J.
   Campolier, M.
   Achten, J.
   Costa, M. L.
TI Wound photography for evaluation of surgical site infection and wound
   healing after lower limb trauma
SO BONE & JOINT JOURNAL
LA English
DT Article
AB Aims
   Deep surgical site infection (SSI) is common after lower limb fracture. We compared the diagnosis of deep SSI using alternative methods of data collection and examined the agreement of clinical photography and in-person clinical assessment by the Centers for Disease Control and Prevention (CDC) criteria after lower limb fracture surgery.
   Methods
   Data from two large, UK-based multicentre randomized controlled major trauma trials investigating SSI and wound healing after surgical repair of open lower limb fractures that could not be primarily closed (UK WOLLF), and surgical incisions for fractures that were primarily closed (UK WHiST), were examined. Trial interventions were standard wound care management and negative pressure wound therapy after initial surgical debridement. Wound outcomes were collected from 30 days to six weeks. We compared the level of agreement between wound photography and clinical assessment of CDC-defined SSI. We are also assessed the level of agreement between blinded independent assessors of the photographs.
   Results
   Rates of CDC-defined deep SSI were 7.6% (35/460) after open fracture and 6.3% (95/1519) after closed incisional repair. Photographs were obtained for 77% and 73% of WOLLF and WHiST cohorts respectively (all participants n = 1,478). Agreement between photographic-SSI and CDC-SSI was fair for open fracture wounds (83%; k = 0.27 (95% confidence interval (CI) 0.14 to 0.42)) and for closed incisional wounds (88%; k = 0.29 (95% CI 0.20 to 0.37)) although the rate of photographically detected deep SSIs was twice as high as CDC-SSI (12% vs 6%). Agreement between different assessors for photographic-SSI (WOLLF 88%, k = 0.63 (95% CI 0.52 to 0.72); WHiST 89%; k = 0.61 (95% CI 0.54 to 0.69)); and wound healing was good (WOLLF 90%; k = 0.80 (95% CI 0.73 to 0.86); WHiST 87%; k = 0.57 (95% CI 0.50 to 0.64)).
   Conclusion
   Although wound photography was feasible within the research context and inter-rater assessor agreement substantial, digital photographs used in isolation overestimated deep SSI rates, when compared to CDC criteria. Wound photography should not replace clinical assessment in pragmatic trials but may be useful for screening purposes where surgical infection outcomes are paramount.
C1 [Bruce, J.] Univ Warwick, Div Hlth Sci, Warwick Clin Trials Unit, Clin Trials, Coventry, W Midlands, England.
   [Knight, R.; Betteridge, R.; Verdon, A.; Brown, J.; Campolier, M.; Achten, J.; Costa, M. L.] Univ Warwick, Coventry, W Midlands, England.
   [Parsons, N.] Univ Warwick, Warwick Med Sch, Stat & Epidemiol Unit, Med Stat, Coventry, W Midlands, England.
C3 University of Warwick; University of Warwick; University of Warwick
RP Bruce, J (通讯作者)，Univ Warwick, Div Hlth Sci, Warwick Clin Trials Unit, Clin Trials, Coventry, W Midlands, England.
EM julie.bruce@warwick.ac.uk
RI ; Parsons, Nathan/AAX-6265-2020; Achten, Juul/KUD-8515-2024; Bruce,
   Julie/G-7588-2014
OI Parsons, Nick/0000-0001-9975-888X; Achten, Juul/0000-0002-8857-5743;
   Costa, Matthew/0000-0003-3644-1388; Betteridge,
   Victoria/0000-0002-4856-429X; Campolier, Marta/0000-0002-7168-2534;
   Knight, Ruth/0000-0001-6810-2845; Bruce, Julie/0000-0002-8462-7999
FU UK National Institute for Health Research (NIHR) Health Technology
   Assessment (HTA) Programme [10/57/20, 14/199/14]; NIHR Oxford Biomedical
   Research Centre; NIHR Research Capability Funding via University
   Hospitals Coventry and Warwickshire NHS Trust; MRC [G106/1178] Funding
   Source: UKRI
FX This work was supported by the UK National Institute for Health Research
   (NIHR) Health Technology Assessment (HTA) Programme: project numbers
   10/57/20 and 14/199/14 for UK WOLLF and UK WHiST trials respectively.
   Support was also provided by the NIHR Oxford Biomedical Research Centre.
   J. Bruce is supported by NIHR Research Capability Funding via University
   Hospitals Coventry and Warwickshire NHS Trust.
CR Achten J, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-022115
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NR 29
TC 9
Z9 15
U1 0
U2 2
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD DEC
PY 2021
VL 103B
IS 12
BP 1802
EP 1808
DI 10.1302/0301-620X.103B12.BJJ-2021-0447
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA VM3AU
UT WOS:000994264100005
PM 34847717
DA 2026-07-24
ER
PT J
AU Pieszko, K
   Pieszko, K
   Wichtowski, M
   Ciesla, S
   Lawnicka, A
   Jamont, R
   Boyd, JB
   Murawa, D
AF Pieszko, Karolina
   Pieszko, Konrad
   Wichtowski, Mateusz
   Ciesla, Slawomir
   Lawnicka, Agnieszka
   Jamont, Robert
   Boyd, J. Brian
   Murawa, Dawid
TI A Randomized Study Comparing Closed-Incision Negative-Pressure Wound
   Therapy with Standard Care in Immediate Breast Reconstruction
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT International Society of Aesthetic Plastic Surgery (ISAPS) World
   Congress
CY SEP 11-13, 2021
CL Vienna, AUSTRIA
ID VACUUM-ASSISTED CLOSURE; MASTECTOMY
AB Background:Breast cancer remains the most common nonskin cancer among women. Prophylactic methods for reducing surgical-site complications after immediate breast reconstruction (IBR) are crucial to prevent acellular dermal matrices or prosthesis exposure and loss. The authors assessed the impact of closed-incision negative-pressure wound therapy (ciNPWT) versus standard dressings (ST) after IBR on surgical-site complications, superficial skin temperature (SST), skin elasticity, and subjective scar quality, to determine the potential benefit of prophylactic ciNPWT application. Methods:A multicenter randomized controlled study of 60 adult female patients was conducted between January of 2019 and July of 2021. All patients had oncologic indications for IBR using implants or expanders. Results:Application of ciNPWT correlated with a significant decrease in surgical-site complications within 1 year of surgery (total, 40%; ST, 60%; ciNPWT, 20%; P = 0.003) and resulted in more elastic scar tissue as measured with a Cutometer (average coefficient of elasticity, 0.74; ST, 0.7; ciNPWT, 0.9; P < 0.001). The SST of each scar 1 week after surgery was significantly higher in the ciNPWT group (average SST, 31.5; ST SST, 31.2; ciNPWT SST, 32.3; P = 0.006). According to the Patient and Observer Scar Assessment Scale v2.0, subjective scar outcomes in both groups were comparable. Conclusions:This is the first randomized controlled study that demonstrated a significant decrease in surgical-site wound complications within 1 year of surgery in IBR patients receiving ciNPWT. A high probability of postoperative radiotherapy should be a relative indication for the use of ciNPWT.
C1 [Pieszko, Karolina; Ciesla, Slawomir; Lawnicka, Agnieszka; Murawa, Dawid] Univ Zielona Gora, Clin Gen Surg & Surg Oncol, Zielona Gora, Poland.
   [Pieszko, Konrad] Univ Zielona Gora, Fac Med & Hlth Sci, Zielona Gora, Poland.
   [Pieszko, Karolina; Jamont, Robert] Hosp Nowa Sol, Dept Plast Surg & Burns, Nowa Sol, Poland.
   [Pieszko, Karolina; Boyd, J. Brian] Harbor UCLA Med Ctr, Dept Surg, Div Plast Surg, Torrance, CA USA.
   [Wichtowski, Mateusz; Murawa, Dawid] Poznan Univ Med Sci, Surg Oncol Clin, Poznan, Poland.
   [Pieszko, Karolina] Zyty 2, PL-665190 Zielona Gora, Poland.
C3 University of Zielona Gora; University of Zielona Gora; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; Poznan University of Medical
   Sciences
RP Pieszko, K (通讯作者)，Zyty 2, PL-665190 Zielona Gora, Poland.
EM drkarolina.pieszko@gmail.com
RI Wichtowski, Mateusz/JND-9290-2023; Pieszko, Konrad/GYE-2249-2022
CR Cabañuz MA, 2019, CIR ESPAN, V97, P156, DOI 10.1016/j.ciresp.2018.10.014
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NR 33
TC 19
Z9 22
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUN
PY 2023
VL 151
IS 6
BP 1123
EP 1133
DI 10.1097/PRS.0000000000010110
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA H2OK6
UT WOS:000994409400022
PM 36728789
DA 2026-07-24
ER
PT J
AU Chen, P
   Vilorio, NC
   Dhatariya, K
   Jeffcoate, W
   Lobmann, R
   McIntosh, C
   Piaggesi, A
   Steinberg, J
   Vas, P
   Viswanathan, V
   Wu, S
   Game, F
AF Chen, Pam
   Vilorio, Nalini Campillo
   Dhatariya, Ketan
   Jeffcoate, William
   Lobmann, Ralf
   McIntosh, Caroline
   Piaggesi, Alberto
   Steinberg, John
   Vas, Prash
   Viswanathan, Vijay
   Wu, Stephanie
   Game, Fran
TI Guidelines on interventions to enhance healing of foot ulcers in people
   with diabetes (IWGDF 2023 update)
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE amputation; diabetes-related foot ulcers; guideline; wound healing
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; RANDOMIZED
   CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; PLATELET-RICH PLASMA;
   CONTROLLED CLINICAL-TRIAL; COLONY-STIMULATING FACTOR;
   EPIDERMAL-GROWTH-FACTOR; QUALITY-OF-LIFE; PLACEBO-CONTROLLED TRIAL
AB Aims: Principles of wound management, including debridement, wound bed preparation, and newer technologies involving alternation of wound physiology to facilitate healing, are of utmost importance when attempting to heal a chronic diabetes-related foot ulcer. However, the rising incidence and costs of diabetes-related foot ulcer management necessitate that interventions to enhance wound healing of chronic diabetes-related foot ulcers are supported by high-quality evidence of efficacy and cost effectiveness when used in conjunction with established aspects of gold-standard multidisciplinary care. This is the 2023 International Working Group on the Diabetic Foot (IWGDF) evidence-based guideline on wound healing interventions to promote healing of foot ulcers in persons with diabetes. It serves as an update of the 2019 IWGDF guideline.
   Materials and Methods: We followed the GRADE approach by devising clinical questions and important outcomes in the Patient-Intervention-Control-Outcome (PICO) format, undertaking a systematic review, developing summary of judgements tables, and writing recommendations and rationale for each question. Each recommendation is based on the evidence found in the systematic review and, using the GRADE summary of judgement items, including desirable and undesirable effects, certainty of evidence, patient values, resources required, cost effectiveness, equity, feasibility, and acceptability, we formulated recommendations that were agreed by the authors and reviewed by independent experts and stakeholders.
   Results: From the results of the systematic review and evidence-to-decision making process, we were able to make 29 separate recommendations. We made a number of conditional supportive recommendations for the use of interventions to improve healing of foot ulcers in people with diabetes. These include the use of sucrose octasulfate dressings, the use of negative pressure wound therapies for postoperative wounds, the use of placental-derived products, the use of the autologous leucocyte/platelet/fibrin patch, the use of topical oxygen therapy, and the use of hyperbaric oxygen. Although in all cases it was stressed that these should be used where best standard of care was not able to heal the wound alone and where resources were available for the interventions.
   Conclusions: These wound healing recommendations should support improved outcomes for people with diabetes and ulcers of the foot, and we hope that wide-scale implementation will follow. However, although the certainty of much of the evidence on which to base the recommendations is improving, it remains poor overall. We encourage not more, but better quality trials including those with a health economic analysis, into this area.
C1 [Chen, Pam] Ramsay Healthcare Australia, Joondalup Hlth Campus, Joondalup, WA, Australia.
   [Chen, Pam] Univ Tasmania, Fac Hlth, Hobart, Tas, Australia.
   [Vilorio, Nalini Campillo] Plaza Salud Gen Hosp, Dept Diabetol, Diabetic Foot Unit, Santo Domingo, Dominican Rep.
   [Dhatariya, Ketan] Norfolk & Norwich Univ Hosp NHS Fdn Trust, Elsie Bertram Diabet Ctr, Norwich, England.
   [Dhatariya, Ketan] Univ East Anglia, Norwich Med Sch, Norwich, England.
   [Lobmann, Ralf] Klinikum Stuttgart, Clin Endocrinol Diabetol & Geriatr, Stuttgart, Germany.
   [McIntosh, Caroline] Univ Galway, Sch Hlth Sci, Podiatr Med, Galway, Ireland.
   [Piaggesi, Alberto] Univ Pisa, Dept Med, Diabetic Foot Sect, Pisa, Italy.
   [Steinberg, John] Georgetown Univ, Sch Med, Georgetown, DC USA.
   [Vas, Prash] Kings Coll Hosp NHS Fdn Trust, London, England.
   [Viswanathan, Vijay] MV Hosp Diabetes, Chennai, India.
   [Viswanathan, Vijay] Prof M Viswanathan Diabet Res Ctr, Chennai, India.
   [Wu, Stephanie] Rosalind Franklin Univ Med & Sci, Dr William M Scholl Coll Podiatr Med, N Chicago, IL USA.
   [Game, Fran] Univ Hosp, Derby Burton NHS Fdn Trust, Derby, England.
C3 University of Tasmania; Norfolk & Norwich University Hospitals NHS
   Foundation Trust; University of East Anglia; University of Stuttgart;
   University Stuttgart Hospital; Ollscoil na Gaillimhe-University of
   Galway; University of Pisa; Georgetown University; King's College
   Hospital NHS Foundation Trust; Rosalind Franklin University of Medicine
   & Science
RP Chen, P (通讯作者)，Ramsay Healthcare Australia, Joondalup Hlth Campus, Joondalup, WA, Australia.; Chen, P (通讯作者)，Univ Tasmania, Fac Hlth, Hobart, Tas, Australia.
EM chenp@ramsayhealth.com.au
OI Campillo-Vilorio, Nalini/0009-0009-8521-4262; McIntosh,
   Caroline/0000-0003-1801-9554; Dhatariya, Ketan/0000-0003-3619-9579;
   Viswanathan, Vijay/0000-0001-9116-3937; Jeffcoate,
   William/0000-0002-1744-7576; Steinberg, John/0000-0003-3665-1481; Chen,
   Pamela/0000-0001-8082-5050; Game, Frances/0000-0002-5294-4789
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NR 265
TC 179
Z9 215
U1 17
U2 119
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAR
PY 2024
VL 40
IS 3
AR e3644
DI 10.1002/dmrr.3644
EA MAY 2023
PG 28
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PN9Z6
UT WOS:000995151700001
PM 37232034
OA hybrid
HC Y
HP N
DA 2026-07-24
ER
PT J
AU van Grinsven, V
   Schouppe, E
   Tollens, T
AF van Grinsven, Vincent
   Schouppe, Ernest
   Tollens, Tim
TI Use of Negative Pressure Wound Therapy to Successfully Treat
   Postoperative Pyoderma Gangrenosum Following Laparoscopic Surgery: A
   Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
AB Introduction. PG is a rare neutrophilic skin disorder with a variable clinical presentation, and diagnosis is often delayed. PPG typically presents as a necrotic ulcerative lesion with surrounding erythema and is often mistaken for a surgical site infection. Delayed diagnosis can lead to extensive morbidity and a prolonged healing time. Case Report. A 75-year-old male presented to the emergency department 2 weeks following laparoscopic appendectomy for acute appendicitis. He had fever and a suspected surgical site infection. Antibiotic treatment was initiated, and debridement was performed. Eventually, the diagnosis of PPG was made. Immunosuppressive therapy combined with NPWT was initiated. Complete wound healing was achieved 2 months after admission. Conclusions. Surgeons should have a high index of suspicion of underlying skin disorders when presumed postoperative wound infections do not respond to aggressive antibiotic and surgical treatment. Early multidisciplinary consultation should be considered. In the case of PPG, the authors of the present report advise early initiation of systemic immunosuppressive therapy combined with atraumatic wound care. NPWT should be considered as appropriate. Surgical debridement may be indicated in the setting of extensive necrosis or uncontrollable superinfection.
C1 [van Grinsven, Vincent] Univ Hosp Leuven, Dept Gen Surg, Leuven, Belgium.
   [Schouppe, Ernest] Univ Hosp Leuven, Dept Plast Surg, Leuven, Belgium.
   [Tollens, Tim] Imelda Hosp, Dept Gen & Abdominal Surg, Bonheiden, Belgium.
   [van Grinsven, Vincent] Herestr 49, B-3000 Vlaams Brabant, Belgium.
C3 KU Leuven; University Hospital Leuven; KU Leuven; University Hospital
   Leuven; Imeldaziekenhuis
RP van Grinsven, V (通讯作者)，Herestr 49, B-3000 Vlaams Brabant, Belgium.
EM vincent.vangrinsven@student.kuleuven.be
OI van Grinsven, Vincent/0000-0002-5513-6971
CR Alavi A, 2017, AM J CLIN DERMATOL, V18, P355, DOI 10.1007/s40257-017-0251-7
   Binus AM, 2011, BRIT J DERMATOL, V165, P1244, DOI 10.1111/j.1365-2133.2011.10565.x
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   Maverakis E, 2018, JAMA DERMATOL, V154, P461, DOI 10.1001/jamadermatol.2017.5980
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   Xia FD, 2018, J AM ACAD DERMATOL, V78, P310, DOI 10.1016/j.jaad.2017.09.040
NR 9
TC 1
Z9 1
U1 1
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2023
VL 35
IS 1
BP E39
EP E41
DI 10.25270/wnds/22065
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA H5DI1
UT WOS:000996162500010
PM 36749997
DA 2026-07-24
ER
PT J
AU Bischoff, A
   Stone, R
   Quisno, A
   Figas, S
   Pierre, A
AF Bischoff, Alex
   Stone, Ryan
   Quisno, Amanda
   Figas, Samantha
   Pierre, Andrew
TI Peroneus Brevis Muscle Flap for a 20-year- old Neuroischemic Diabetic
   Ulcer Induced by Traumatic Injury: A Case Report Detailing the Efficacy
   of Advanced Combined Treatment Modalities for Chronic Wound Closure
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE orthoplastics; peroneus brevis; muscle flap; pedicle flap; chronic
   osteomyelitis; chronic wound
ID EXTERNAL FIXATION; RECONSTRUCTIVE SURGERY; EXPERIENCES; THERAPY
AB Introduction. Peroneus brevis flaps provide a viable option to achieve soft tissue coverage in hard-to-heal lower extremity wounds, specifically those to the lateral ankle and hindfoot. Case Report. The authors present a unique case of a patient with a 20-year-old wound dehiscence complicated by osteomyelitis. The wound was a complication from a lateral extensile incision utilized during prior calcaneal open reduction and internal fixation. Due to many factors, including multiple comorbidities, the patient could not obtain complete healing despite IV antibiotics, vascular optimization, local wound care, surgical debridement, and grafting. Wound closure was ultimately achieved with a PB muscle flap. Adjunctive therapies also utilized included multilevel ring external fixation, negative pressure wound therapy, and hyperbaric oxygen therapy. On follow-up 32 months after the procedure, the patient continued to be wound free and satisfied with the results. Conclusions. This case report demonstrates the utility of PB muscle flaps for hard-to-heal lower extremity wounds in patients with comorbidities.
C1 [Bischoff, Alex; Stone, Ryan; Quisno, Amanda] Grant Med Ctr, Foot & Ankle Surg Residency, Columbus, OH USA.
   [Quisno, Amanda] Foot & Ankle Specialists Cent Ohio, Gahanna, OH USA.
   [Figas, Samantha] Cleveland Clin, Akron Gen Phys Med Grp, Akron, OH USA.
   [Pierre, Andrew] Nashville Gen Hosp, Dept Orthopaed, Nashville, TN USA.
   [Bischoff, Alex] Grant Med Ctr, Med Educ Dept, Foot & Ankle Residency Program, 111 South Grant Ave, Columbus, OH 43215 USA.
C3 Cleveland Clinic Foundation
RP Bischoff, A (通讯作者)，Grant Med Ctr, Med Educ Dept, Foot & Ankle Residency Program, 111 South Grant Ave, Columbus, OH 43215 USA.
EM Alex.Bischoff@ohiohealth.com
CR Abd-Al-Moktader MA, 2018, J RECONSTR MICROSURG, V34, P616, DOI 10.1055/s-0038-1661366
   Antonini A, 2017, INJURY, V48, pS76, DOI 10.1016/S0020-1383(17)30663-0
   Bajantri Babu, 2013, Indian J Plast Surg, V46, P48, DOI 10.4103/0970-0358.113706
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   Belczyk RJ, 2011, CLIN PODIATR MED SUR, V28, P649, DOI 10.1016/j.cpm.2011.07.001
   Bui PV, 2020, CLIN PODIATR MED SUR, V37, P649, DOI 10.1016/j.cpm.2020.07.004
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   Erne H, 2016, INJURY, V47, P1288, DOI 10.1016/j.injury.2016.02.017
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   Yang Yu-Li, 2005, J Foot Ankle Surg, V44, P259, DOI 10.1053/j.jfas.2005.04.013
NR 27
TC 0
Z9 0
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2023
VL 35
IS 1
BP E42
EP E46
DI 10.25270/wnds/22008
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA H5DI1
UT WOS:000996162500011
PM 36749998
DA 2026-07-24
ER
PT J
AU Zhang, Y
   Wang, TL
   Liu, Y
   Dong, JS
   Yang, JF
   Xu, H
AF Zhang, Yi
   Wang, Tingliang
   Liu, Ying
   Dong, Jiasheng
   Yang, Jiafei
   Xu, Hua
TI Comparison of Negative Pressure Dressing and Conventional Dressing in
   the Management of Skin Grafts at the Donor Site of the Latissimus Dorsi
   Flap
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE latissimus dorsi flap; donor site complication; seroma formation;
   negative pressure dressing; split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; BREAST RECONSTRUCTION;
   PREVENTING SEROMA; MORBIDITY; HARVEST
AB Introduction. Delayed and incomplete healing of the skin graft at the donor site of an LD flap is common because of seroma formation. The authors aimed to evaluate whether the application of an NPD could improve the healing process after STSG at LD donor sites. Materials and Methods. From July 2019 to September 2021, 32 patients underwent STSG with NPD at the LD donor site, and 27 patients underwent STSG with TBDs. Data were collected and analyzed using the chi-square test, t test, and Spearman correlation test. Results. The overall Spearman correlations of graft loss with seroma, hematoma, and infection were 0.56 (P <.01), 0.64 (P <.01), and 0.70 (P <.01), respectively. Compared with the TBD group, the STSG take rate was significantly higher in the NPD group (90.3% vs 84.5%, P =.046) while the seroma rate (18.8% vs 44.4%, P =.033), graft loss (9.4% vs 29.6%, P =.047), and mean length of stay (10.9 +/- 1.8 vs 12.1 +/- 2.4, P =.037) were significantly lower. Conclusions. NPDs for STSG at the LD donor site contribute significantly to improved graft acceptance with reduced seroma formation.
C1 [Zhang, Yi; Wang, Tingliang; Liu, Ying; Dong, Jiasheng; Yang, Jiafei; Xu, Hua] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Shanghai, Peoples R China.
   [Xu, Hua] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Xu, H (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
EM drxuhua9y@aliyun.com
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   Bassetto F, 2021, WOUNDS, DOI [10.25270/wnds/081421.01, 10.25270/wnds/081421.01, DOI 10.25270/WNDS/081421.01]
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   Kim S, 2020, MICROSURG, V40, P700, DOI 10.1002/micr.30626
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   Lee JS, 2019, AESTHET PLAST SURG, V43, P1515, DOI 10.1007/s00266-019-01458-7
   Liu X, 2018, INT J SURG, V53, P72, DOI 10.1016/j.ijsu.2018.02.064
   Mutlu OO, 2016, J CRANIOFAC SURG, V27, pE553, DOI 10.1097/SCS.0000000000002862
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   Sajid MS, 2011, CLIN BREAST CANCER, V11, P357, DOI 10.1016/j.clbc.2011.04.006
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NR 27
TC 5
Z9 5
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2023
VL 35
IS 1
BP E69
EP E73
DI 10.25270/wnds/22055
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA H5DI1
UT WOS:000996162500014
PM 37018743
DA 2026-07-24
ER
PT J
AU Rollins, A
   Ho, K
   Fernandez, LG
   Lardizabal, MA
   Roth, B
   O'Keefe, SF
   Matthews, MR
AF Rollins, Austin
   Ho, Kristie
   Fernandez, Luis G.
   Lardizabal, Marisse A.
   Roth, Bryan
   O'Keefe, Sean F.
   Matthews, Marc R.
TI The Sandwich Technique for Quick and Efficient Application of Negative
   Pressure Wound Therapy to the Feet and Hands: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE acrylic drape; burns; diabetic foot ulcer; negative pressure wound
   therapy; sandwich technique; wound healing
ID VACUUM-ASSISTED CLOSURE
AB Introduction. NPWT is a surgical dressing that combines polyurethane foam with the subsequent application of continuous or intermittent negative pressure. NPWT facilitates granulation tissue production by macrostrain, microstrain and, if desired, fluid instillation. Sealing the polyurethane foam over the wound bed is achieved using acrylic drapes; however, this can be difficult to use in some anatomic sites. Failure to achieve an effective seal can necessitate additional supplies, which has led to increased innovation in developing a more effective NPWT seal over the target wound bed. Obtaining an effective pressure seal on the feet or hands can be difficult because these anatomic sites have distinct curvature for each digit, with multiple interdigital web spaces and independent mobility. In this case report, the authors propose a technique to apply either an acrylic drape or combination acrylic and soft silicone drape utilizing the "sandwich technique" to seal NPWT foam quickly and efficiently to the feet or hands.
C1 [Rollins, Austin; Ho, Kristie] Valleywise Hlth Med Ctr, Dept Podiatry, Podiatr Surg Resident, Phoenix, AZ USA.
   [Fernandez, Luis G.] Univ Texas Hlth Sci Ctr, Dept Surg, Div Trauma Surg Surg Crit Care, Tyler, TX USA.
   [Lardizabal, Marisse A.] Valleywise Hlth Med Ctr, Dept Podiatry, Phoenix, AZ USA.
   [Roth, Bryan] Valleywise Med Ctr, Dept Podiatry, Phoenix, AZ USA.
   [O'Keefe, Sean F.] Business Dev Manager 3M, Phoenix, AZ USA.
   [Matthews, Marc R.] Univ Arizona, Phoenix, AZ USA.
   [Matthews, Marc R.] Creighton Univ, Sch Med, Arizona Burn Ctr, Phoenix, AZ USA.
   [Matthews, Marc R.] Arizona Burn Ctr, 1602 East Roosevelt St, Phoenix, AZ 85008 USA.
C3 University of Texas System; University of Texas at Tyler; University of
   Texas-Health Sciences Center at Tyler (UTHSCT); University of Arizona;
   Creighton University
RP Matthews, MR (通讯作者)，Arizona Burn Ctr, 1602 East Roosevelt St, Phoenix, AZ 85008 USA.
EM marc_matthews@dmgaz.org
RI OKeefe, Sean/N-3101-2016
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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   Fernández LG, 2020, INT WOUND J, V17, P1829, DOI 10.1111/iwj.13471
   Fernandez LG, 2019, CUREUS J MED SCIENCE, V11, DOI 10.7759/cureus.5183
   Gabriel A, 2012, INT WOUND J, V9, P25, DOI 10.1111/j.1742-481X.2012.01014.x
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   Kim PJ, 2018, WOUNDS, pS1
   Matthews MR, 2022, WOUNDS, V34, P141, DOI 10.25270/wnds/082421.02
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NR 14
TC 2
Z9 2
U1 1
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2023
VL 35
IS 1
BP E117
EP E121
DI 10.25270/wnds/22024
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA H5DI1
UT WOS:000996162500015
PM 36749993
DA 2026-07-24
ER
PT J
AU Balan, N
   Qi, X
   Keeley, J
   Neville, A
AF Balan, Naveen
   Qi, Xin
   Keeley, Jessica
   Neville, Angela
TI A Novel Strategy to Manage Below-Knee-Amputation (BKA) Stump
   Complications for Early Wound Healing and BKA Salvage
SO AMERICAN SURGEON
LA English
DT Article
DE acute care surgery; ambulatory status; negative pressure wound therapy;
   severe diabetic foot infection; time to prosthesis
ID LOWER-EXTREMITY AMPUTATION; RISK-FACTORS; READMISSION; SERIES
AB Introduction The optimal management of major stump complications (operative infection or dehiscence) following below-knee-amputation (BKA) is unknown. We evaluated a novel operative strategy to aggressively treat major stump complications hypothesizing it would improve our rate of BKA salvage. Methods Retrospective review of patients requiring operative intervention for BKA stump complications between 2015 and 2021. A novel strategy employing staged operative debridement for source control, negative pressure wound therapy, and reformalization was compared to standard care (less structured operative source control or above knee amputation). Results 32 patients were studied, 29 of which were male (90.6%) with an average age of 56.1 +/- 9.6 y. 30 (93.8%) had diabetes and 11 (34.4%) peripheral arterial disease (PAD). The novel strategy was used in 13 patients and 19 had standard care. Novel strategy patients had higher BKA salvage rates, 100% vs 73.7% (P = .064), and postoperative ambulatory status, 84.6% vs 57.9% (P = .141). Importantly, none of the patients undergoing the novel therapy had PAD, while all progressing to above-knee amputation (AKA) did. To better assess the efficacy of the novel technique, patients progressing to AKA were excluded. Patients undergoing novel therapy who had their BKA level salvaged (n = 13) were compared to usual care (n = 14). The novel therapy's time to prosthetic referral was 72.8 +/- 53.7 days vs 247 +/- 121.6 days (P < .001), but they did undergo more operations (4.3 +/- 2.0 vs 1.9 +/- 1.1, P < .001). Conclusion Utilization of a novel operative strategy for BKA stump complications is effective in salvaging BKAs, particularly for patients without PAD.
C1 [Balan, Naveen; Qi, Xin; Keeley, Jessica; Neville, Angela] Harbor UCLA Med Ctr, Harbor, OR USA.
   [Neville, Angela] Harbor UCLA Med Ctr, 1000 W Carson St, Torrance, CA 90502 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center
RP Neville, A (通讯作者)，Harbor UCLA Med Ctr, 1000 W Carson St, Torrance, CA 90502 USA.
EM aneville@dhs.lacounty.gov
RI Qi, Xin/JCE-7825-2023
OI Qi, Xin/0000-0003-4066-8710; Balan, Naveen/0000-0002-7233-1306; Neville,
   Angela/0000-0002-7660-4711; Keeley, Jessica/0000-0001-6196-5330
CR Aulivola B, 2004, ARCH SURG-CHICAGO, V139, P395, DOI 10.1001/archsurg.139.4.395
   Capobianco Claire M, 2009, Clin Podiatr Med Surg, V26, P619, DOI 10.1016/j.cpm.2009.08.002
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   Chopra A, 2018, J VASC SURG, V67, P1521, DOI 10.1016/j.jvs.2017.10.051
   Creager MA, 2021, CIRCULATION, V143, pE875, DOI 10.1161/CIR.0000000000000967
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   Jeffery K., 2018, ORTHOPEDIC P, V92, P227
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   Wong LH, 2021, CLIN ORTHOP RELAT R, V479, P324, DOI 10.1097/CORR.0000000000001455
NR 13
TC 4
Z9 4
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD OCT
PY 2023
VL 89
IS 10
BP 4055
EP 4060
DI 10.1177/00031348231175504
EA MAY 2023
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA Y7BE9
UT WOS:001001013900001
PM 37195758
OA hybrid
DA 2026-07-24
ER
PT J
AU Sun, HJ
   Yang, CX
   Liu, XK
   Liang, J
   Geng, HF
AF Sun, Haojie
   Yang, Chengxin
   Liu, Xuekui
   Liang, Jun
   Geng, Houfa
TI Effectiveness of Negative Pressure Wound Therapy of Diabetic Foot Ulcers
   Using Periplaneta Americana (Kangfuxin Liquid) Irrigation
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE diabetic foot ulcers; Kangfuxin liquid; negative-pressure wound therapy
   with instillation; wound healing
ID ANTISEPTIC SOLUTION; NORMAL SALINE; OUTCOMES
AB This study was to evaluate the efficacy of Periplaneta Americana (Kangfuxin Liquid) relative to normal saline when applied in negative-pressure wound therapy (NPWT) with instillation for facilitating diabetic foot ulcers (DFUs) healing. Eighty patients with Wagner grades 3 or 4 DFUs were enrolled in this retrospective study. Based on the treatment type, patients were equally assigned to either (i) an NPWT with Kangfuxin liquid instillation group (NPWT-K) or (ii) an NPWT with normal saline instillation group (NPWT-I). The primary study outcome was the wound healing rate and Kaplan-Meier survival estimate was used to examine the cumulative wound healing rate, while the secondary outcomes were the amputation rate, inpatient days, duration of antibiotic treatments, reinfection rate, new ulcer formation rate, readmission rate, and changes in the inflammatory markers (such as ESR, CRP, and PCT) and serum growth factors (including VEGF, EGF, and bFGF). The 12-week wound healing rate (31 of 40[77.5%] vs 22 of 40[55.0%], P = .033) and the cumulative wound healing rate was higher in the NPWT-K group than in the NPWT-I group (P = .004). The wound healing time was shorter in the NPWT-K group (55 days [95% CI 50-60]) than in the NPWT-K group (64 days [95% CI 59-69], P = .016). Patients who received NPWT-K had fewer inpatient days and duration of antibiotic treatment and faced lower reinfection and readmission rates (P < .05). After 1 week of treatment, the ESR, CRP, and PCT levels in the blood were lower in the NPWT-K group than in the NPWT-I group (P < .05), while the VEGF, EGF, and bFGF levels in the NPWT-K group were higher than those in the NPWT-I group (P < .001). The present study showed that NPWT with Kangfuxin liquid instillation was effective and showed significantly accelerated DFUs healing. Thus, Kangfuxin liquid is an effective instillation solution for use in the treatment of DFUs with NPWT.
C1 [Sun, Haojie; Liu, Xuekui; Liang, Jun] Southeast Univ, Xuzhou Med Univ, Xuzhou Cent Hosp, Affiliated XuZhou Hosp,Med Coll,Xuzhou Clin Sch, Xuzhou, Jiangsu, Peoples R China.
   [Yang, Chengxin; Geng, Houfa] Xuzhou Med Univ, Xuzhou, Jiangsu, Peoples R China.
   [Geng, Houfa] Xuzhou Med Univ, Xuzhou 221000, Jiangsu, Peoples R China.
   [Liang, Jun] Southeast Univ, Xuzhou Med Univ, Xuzhou Cent Hosp, Affiliated XuZhou Hosp,Med Coll,Xuzhou Clin Sch, Xuzhou 221009, Jiangsu, Peoples R China.
C3 Southeast University - China; Xuzhou Medical University; Xuzhou Medical
   University; Xuzhou Medical University; Southeast University - China;
   Xuzhou Medical University
RP Geng, HF (通讯作者)，Xuzhou Med Univ, Xuzhou 221000, Jiangsu, Peoples R China.; Liang, J (通讯作者)，Southeast Univ, Xuzhou Med Univ, Xuzhou Cent Hosp, Affiliated XuZhou Hosp,Med Coll,Xuzhou Clin Sch, Xuzhou 221009, Jiangsu, Peoples R China.
EM mwlj521@njmu.edu.cn; genghoufa@njmu.edu.cn
RI Houfa, Geng/ABI-6352-2020; Sun, Haojie/LRT-6797-2024
FU Xuzhou Primary Research & Development projects [KC21274]; Pengcheng
   Talents-Medical Youth Reserve Talents [XWRCHT20220004]
FX The author(s) disclosed receipt of the following financial supportfor
   the research, authorship, and/or publication of this article:This work
   was supported by Xuzhou Primary Research & Development projects,
   KC21274; Pengcheng Talents-Medical Youth Reserve Talents,
   XWRCHT20220004.
CR [Anonymous], 2004, WOUNDS, p3S
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   Chen XH, 2009, INT J RADIAT BIOL, V85, P607, DOI 10.1080/09553000902985110
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   Li LJ, 2019, BIOMED PHARMACOTHER, V114, DOI 10.1016/j.biopha.2019.108858
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   Liu CH, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/1664225
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   Yang H, 2021, THER CLIN RISK MANAG, V17, P65, DOI 10.2147/TCRM.S282840
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   Zhu JJ, 2018, MOLECULES, V23, DOI 10.3390/molecules23010101
NR 35
TC 1
Z9 5
U1 4
U2 29
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2025
VL 24
IS 4
BP 1165
EP 1172
DI 10.1177/15347346231176917
EA MAY 2023
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 9IU0P
UT WOS:001001167000001
PM 37203153
DA 2026-07-24
ER
PT J
AU Lumsden, EJ
   Kimble, RM
   McMillan, C
   Storey, K
   Ware, RS
   Griffin, B
AF Lumsden, Emma Joan
   Kimble, Roy M.
   McMillan, Catherine
   Storey, Kristen
   Ware, Robert S.
   Griffin, Bronwyn
TI Protocol for a feasibility, acceptability and safety study of the PICO
   device (negative pressure wound therapy) in acute paediatric burns
SO BMJ OPEN
LA English
DT Article
DE surgery; paediatric surgery; qualitative research; statistics & research
   methods; clinical trials; wound management
ID ASSESSMENT SCALE; SAMPLE-SIZE; PILOT; PAIN; ULTRASOUND; CHILDREN;
   QUALITY; TOOL
AB IntroductionNegative pressure wound therapy (NPWT) in acute burn care may decrease the time to re-epithelialisation by more than 20%. Despite this, the perceived burden of use; including therapeutic, physical and financial, have limited the use of NPWT in acute burn care. This might be minimised by using the small, ultraportable, single-use NPWT device PICO as opposed to larger devices, which to date has never been studied in acute burn care. This research will; therefore, primarily assess the feasibility, acceptability and safety of PICO in paediatric burns. Secondary outcomes include time to re-epithelialisation, pain, itch, cost and scar formation.Methods and analysisThis protocol details a clinical trial methodology and is pre-results. This single site, prospective, pilot randomised controlled trial will be conducted in an Australian quaternary paediatric burns centre. Participants must be aged <= 16 years, otherwise well and managed within 24 hours of sustaining a burn that fits beneath a PICO dressing. Thirty participants will be randomised to one of three groups: group A: Mepitel and ACTICOAT, group B: Mepitel, ACTICOAT and PICO and group C: Mepitel, ACTICOAT Flex and PICO. Patient outcomes will be recorded at each dressing change to assess efficacy and safety outcomes until 3 months postburn wound re-epithelialisation. Surveys, randomisation and data storage will be undertaken via online platforms and physical data storage collated at the Centre for Children's Health Research, Brisbane, Australia. Analysis will be done by using StataSE 17.0 statistical software.Ethics and disseminationEthics has been obtained from Queensland Health and Griffith Human Research Ethics committees including a site-specific approval. These data will be disseminated via clinical meetings, conference presentations and peer-reviewed journals.
C1 [Lumsden, Emma Joan; Kimble, Roy M.; Ware, Robert S.; Griffin, Bronwyn] Griffith Univ, Fac Hlth, Southport, Qld, Australia.
   [Lumsden, Emma Joan; Kimble, Roy M.; McMillan, Catherine; Storey, Kristen] Queensland Childrens Hosp, Burns Dept, South Brisbane, Qld, Australia.
   [Lumsden, Emma Joan; Kimble, Roy M.; Griffin, Bronwyn] Ctr Childrens Hlth Res, Burns & Trauma Res Grp, Brisbane, Qld, Australia.
   [Ware, Robert S.; Griffin, Bronwyn] Griffith Univ, Menzies Hlth Inst Queensland, Nathan, Qld, Australia.
C3 Griffith University; Childrens Health Queensland Hospital & Health
   Service; Queensland Childrens Hospital; Griffith University
RP Lumsden, EJ (通讯作者)，Griffith Univ, Fac Hlth, Southport, Qld, Australia.; Lumsden, EJ (通讯作者)，Queensland Childrens Hosp, Burns Dept, South Brisbane, Qld, Australia.; Lumsden, EJ (通讯作者)，Ctr Childrens Hlth Res, Burns & Trauma Res Grp, Brisbane, Qld, Australia.
EM emma.lumsden@health.qld.gov.au
RI Griffin, Bronwyn/AEB-6299-2022; Ware, Robert/B-2024-2014; Kimble,
   Roy/B-4160-2011
OI Griffin, Bronwyn/0000-0002-6182-9125; Ware, Robert/0000-0002-6129-6736;
   Luden, Emma/0000-0002-5437-9701; 
FU Smith Nephew; Smith and Nephew [IIS721]
FX This research was grant funded by Smith & Nephew which partially funded
   the trial. They had no input into study design. Smith and Nephew grant
   number IIS721.
CR Bairagi A, 2019, BURNS TRAUMA, V7, DOI 10.1186/s41038-019-0165-0
   Bauer MS, 2020, PSYCHIAT RES, V283, DOI 10.1016/j.psychres.2019.04.025
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   Chong HP, 2020, BURNS, V46, P483, DOI 10.1016/j.burns.2019.08.014
   Clavien PA, 2009, ANN SURG, V250, P187, DOI 10.1097/SLA.0b013e3181b13ca2
   Cuomo R, 2021, J INVEST SURG, V34, P335, DOI 10.1080/08941939.2019.1616009
   Daigle P, 2013, WOUND REPAIR REGEN, V21, P498, DOI 10.1111/wrr.12052
   Everett T, 2015, J BURN CARE RES, V36, P44, DOI 10.1097/BCR.0000000000000129
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   Goei H, 2017, BURNS, V43, P715, DOI 10.1016/j.burns.2016.10.012
   Health AIo Welfare, 2022, AUSTR CHILDREN
   Hicks CL, 2001, PAIN, V93, P173, DOI 10.1016/S0304-3959(01)00314-1
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   Lifland BE, 2018, ACAD PEDIATR, V18, P376, DOI 10.1016/j.acap.2017.12.001
   Lonie S, 2017, BURNS, V43, P509, DOI 10.1016/j.burns.2016.09.011
   Lumsden E., REVIEW, DOI [10.21203/rs.3.rs-2335693/v1, DOI 10.21203/RS.3.RS-2335693/V1]
   Ma ZJ, 2017, INT J MOL MED, V40, P1415, DOI 10.3892/ijmm.2017.3131
   Martin G, 2008, BURNS, V34, P498, DOI 10.1016/j.burns.2007.08.004
   McBride CA, 2018, BURNS TRAUMA, V6, DOI 10.1186/s41038-018-0135-y
   Morris V, 2012, J BURN CARE RES, V33, P419, DOI 10.1097/BCR.0b013e3182372bfa
   Morykwas MJ, 1999, J BURN CARE REHABIL, V20, P15, DOI 10.1097/00004630-199901001-00003
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NR 37
TC 3
Z9 3
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY
PY 2023
VL 13
IS 5
DI 10.1136/bmjopen-2022-068499
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA I3JU6
UT WOS:001001783700072
PM 37137557
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ciuntu, BM
   Vintila, D
   Tanevski, A
   Chiriac, S
   Stefanescu, G
   Abdulan, IM
   Balan, GG
   Veliceasa, B
   Badulescu, OV
   Ghiga, G
   Fatu, AM
   Georgescu, A
   Vascu, MB
   Vasilescu, AM
AF Ciuntu, Bogdan Mihnea
   Vintila, Dan
   Tanevski, Adelina
   Chiriac, Stefan
   Stefanescu, Gabriela
   Abdulan, Irina Mihaela
   Balan, Gheorghe G.
   Veliceasa, Bogdan
   Badulescu, Oana Viola
   Ghiga, Gabriela
   Fatu, Ana Maria
   Georgescu, Andrei
   Vascu, Mihai Bogdan
   Vasilescu, Alin Mihai
TI Severe Acute Pancreatitis Treated with Negative Pressure Wound Therapy
   System: Influence of Laboratory Markers
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE negative pressure wound therapy system; open abdomen; severe acute
   pancreatitis; abdominal compartment syndrome
ID ABDOMINAL COMPARTMENT SYNDROME; FLUID RESUSCITATION; INTRAABDOMINAL
   HYPERTENSION; OPEN ABDOMEN; OUTCOMES
AB (1) Background: An open abdomen is a serious medical condition that requires prompt and effective treatment to prevent complications and improve patient outcomes. Negative pressure therapy (NPT) has emerged as a viable therapeutic option for temporary closure of the abdomen, offering several benefits over traditional methods.(2) Methods: We included 15 patients with pancreatitis who were hospitalized in the I-II Surgery Clinic of the Emergency County Hospital "St. Spiridon" from Iasi, Romania, between 2011-2018 and received NPT. (3) Results: Preoperatively, the mean IAP level was 28.62 mmHg, decreasing significantly postoperatively to 21.31 mmHg. The mean level of the highest IAP value recorded in pancreatitis patients treated with VAC did not differ significantly by lethality (30.31 vs. 28.50; p = 0.810). In vacuum-treated pancreatitis patients with a IAP level > 12, the probability of survival dropped below 50% during the first 7 days of stay in the ICU, so that after 20 days the probability of survival was approximately 20%. IAP enters the determinism of surgery with a sensitivity of 92.3% and a specificity of 99%, the cut-off value of IAP being 15 mmHg.(4) Conclusions: The timing of surgical decompression in abdominal compartment syndrome is very important. Consequently, it is vital to identify a parameter, easy to measure, within the reach of any clinician, so that the indication for surgical intervention can be made judiciously and without delay.
C1 [Ciuntu, Bogdan Mihnea; Vintila, Dan; Tanevski, Adelina; Vasilescu, Alin Mihai] Grigore T Popa Univ Med & Pharm, Dept Gen Surg, Iasi 700115, Romania.
   [Chiriac, Stefan; Stefanescu, Gabriela; Balan, Gheorghe G.] Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.
   [Abdulan, Irina Mihaela] Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
   [Veliceasa, Bogdan] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Traumatol & Orthopaed, Iasi 700115, Romania.
   [Badulescu, Oana Viola] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Haematholohy, Iasi 700115, Romania.
   [Ghiga, Gabriela] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Mother & Child Med, Iasi 700115, Romania.
   [Fatu, Ana Maria] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Implantol Removable Denture Technol, Discipline Ergon, Iasi 700115, Romania.
   [Georgescu, Andrei; Vascu, Mihai Bogdan] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Odontol Periodontol & Fixed Prosthesi, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy; Grigore T Popa University of
   Medicine & Pharmacy; Grigore T Popa University of Medicine & Pharmacy;
   Grigore T Popa University of Medicine & Pharmacy
RP Stefanescu, G (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.; Abdulan, IM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; dan.vintila@umfiasi.ro;
   papancea.adelina@umfiasi.ro; stefanchiriac@yahoo.com;
   gabriela.stefanescu@gmail.com; irina.abdulan@yahoo.com;
   gheorghe-g-balan@umfiasi.ro; bogdan.veliceasa@umfiasi.ro;
   viola.badulescu@umfiasi.ro; gabriela.ghiga@umfiasi.ro;
   ana.fatu@umfiasi.ro; andrei.georgescu@umfiasi.ro;
   mihai.vascu@umfiasi.ro; alin.vasilescu@umfiasi.ro
RI Fatu, ANA/MTE-5072-2025; Tanevski, Adelina/LUZ-8095-2024; Ciuntu,
   Bogdan/MTF-9477-2025; Veliceasa, Bogdan/AFV-2751-2022; Abdulan,
   Irina/AAA-3089-2020; Balan, Gheorghe/OZF-7157-2025; Vascu, Mihai
   Bogdan/MTE-8733-2025; Georgescu, Andrei/KFB-5405-2024; Chiriac,
   Stefan/MTF-7600-2025; Vasilescu, Alin Mihai/HPE-4046-2023
OI Veliceasa, Bogdan/0000-0002-9941-3424; Stefanescu,
   Gabriela/0000-0002-1394-8648; Vascu, Mihai Bogdan/0009-0009-2470-4735;
   Georgescu, Andrei/0000-0001-7407-844X; Chiriac,
   Stefan/0000-0003-2497-9236; Vasilescu, Alin Mihai/0000-0002-9865-5114
CR Aggarwal A, 2014, WORLD J GASTROENTERO, V20, P18092, DOI 10.3748/wjg.v20.i48.18092
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NR 30
TC 0
Z9 0
U1 0
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY 28
PY 2023
VL 12
IS 11
AR 3721
DI 10.3390/jcm12113721
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA I9GK3
UT WOS:001005789500001
PM 37297916
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chang, CH
   Huang, CC
   Lin, CM
   Huang, SM
   Lin, CC
   Chuang, CC
   Hsu, H
AF Chang, Chien-Hwa
   Huang, Chieh-Chi
   Lin, Chi-Ming
   Huang, Shih-Ming
   Lin, Chung-Chiao
   Chuang, Chun-Chi
   Hsu, Honda
TI Evaluating the effectiveness of using negative pressure wound therapy in
   the preservation of the infected prosthetic aortic graft
SO SURGERY
LA English
DT Article; Proceedings Paper
CT World Union Wound Healing Societies
CY MAR 08-12, 2020
CL U ARAB EMIRATES
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; MEDIASTINITIS; MANAGEMENT
AB Background: Infected deep sternal infection due to an associated infection of the prosthetic aortic graft is a devastating condition. Standard management requires the removal of the graft and substituting it with a new one. Often, removal of the prosthetic graft is close to impossible. Negative pressure wound therapy is currently the treatment of choice for patients with deep sternal infection. However, its use in deep sternal infection with exposed infected prosthetic aortic graft has not been well described.
   Methods: Eight patients were included in this study. All had type A aortic dissection of the ascending aorta and/or aortic arch.
   Results: There were 7 men and 1 woman. The median age was 53 years old (range 33-81 years old). The median number of days from the initial aortic operation to the diagnosis of infection was 20 days (range 14-52). The median length of stay in the intensive care unit was 17 days ( range 6-338 days). The median time interval from the initial debridement to reconstruction was 20 days (range 6-43 days). The median number of times negative pressure wound therapy was changed was 4 (range 2-9). The most common flap used for reconstruction was the pectoralis major musculocutaneous flap in 7 patients, a free antero-lateral thigh flap in 1 patient, and pedicled omental flap in combination with pectoralis major musculocutaneous flap in 1 patient. One patient had persistent recurrent infection of the graft despite negative pressure wound therapy and flap reconstruction. The median length of follow-up was 38.5 months (range 4-120 months).
   Conclusion: This small study suggests that negative pressure wound therapy could be used successfully for the management of deep sternal infection due to infected prosthetic aortic grafts. In most cases, it eliminated the need to replace the infected prosthetic aortic graft in high-risk patients. (c) 2022 Elsevier Inc. All rights reserved.
C1 [Chang, Chien-Hwa; Huang, Shih-Ming] Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Div Cardiovasc Surg, Dalin, Taiwan.
   [Huang, Chieh-Chi; Lin, Chi-Ming; Lin, Chung-Chiao; Chuang, Chun-Chi; Hsu, Honda] Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Div Plast Surg, Dalin, Taiwan.
   [Huang, Chieh-Chi; Hsu, Honda] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Buddhist Tzu Chi General Hospital;
   Tzu Chi University
RP Hsu, H (通讯作者)，Dalin Tzu Chi Hosp, Div Plast Surg, Buddhist Tzu Chi Med Fdn, 2 Ming Sheng Rd, Dalin 622, Taiwan.
EM hondahsu@yahoo.com.tw
OI , Shivani Kumari/0009-0000-2609-7005; Chang, John
   Chien-Hwa/0000-0002-1845-9915
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 20
TC 2
Z9 2
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD OCT
PY 2022
VL 172
IS 4
BP 1179
EP 1184
DI 10.1016/j.surg.2022.05.015
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA J4QL8
UT WOS:001009474000017
PM 35927080
DA 2026-07-24
ER
PT J
AU Klein, R
   Mathew, R
   Spangler, DJ
   Hudson, H
   Soloway, L
   Bongards, C
AF Klein, Robert
   Mathew, Rhea
   Spangler, Daniel J.
   Hudson, Hadley
   Soloway, Laura
   Bongards, Christine
TI Use of Disposable Negative Pressure Wound Therapy in 16 Podiatry Clinic
   Patients with Chronic Wounds
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE diabetic foot; lower extremity; negative pressure wound therapy;
   pressure injury; wound healing
AB BACKGROUND: Disposable mechanical negative pressure wound therapy (dNPWT) can help manage lower extremity wounds in the outpatient clinic. PURPOSE: We assessed dNPWT use in 16 patients at a podiatry clinic. METHODS: Patients were treated between October 31, 2019 and December 16, 2021. All patients received dNPWT with dressing changes every 2 to 3 days. Demographics, baseline wound and subsequent wound visit data, and treatments were recorded. Wound healing outcomes were assessed. RESULTS: Average patient age was 59.6 +/- 8.9 years old. Patient comorbidities included poor nutritional status, diabetes, and hypertension. Wound types consisted of 6 diabetic foot ulcers, 9 surgical wounds, and 1 pressure injury. At baseline, the average wound age was 15.6 weeks, average area was 5.5 cm2, and average volume was 3.3 cm3. The average time from presentation to end of dNPWT was 45.5 days. In this timeframe, wounds improved in granulation tissue amount (81%), reduced in area (63%), and reduced in volume (69%). By the end of treatment, a majority of patients (88%) displayed 76% to 100% wound bed coverage with healthy granulation tissue. The remaining 12% showed <76% coverage with granulation tissue. CONCLUSIONS: In this retrospective study, 14 of 16 patients displayed improvement in wound area, volume, and granulation tissue amount during dNPWT treatment.
C1 [Klein, Robert; Mathew, Rhea; Spangler, Daniel J.] Univ South Carolina, Sch Med, Greenville, SC USA.
   [Klein, Robert] PRISMA Hlth Upstate, Greenville, SC USA.
   [Hudson, Hadley] Furman Univ, Greenville, SC USA.
   [Soloway, Laura] 3M, St Paul, MN USA.
   [Bongards, Christine] 3M Deutschland GmbH, 3M, Neuss, Germany.
   [Klein, Robert] Prisma Hlth Upstate Greenville, 200 Patewood Dr, Suite C300, Greenville, SC 29615 USA.
C3 Prisma Health; 3M; 3M
RP Klein, R (通讯作者)，Prisma Hlth Upstate Greenville, 200 Patewood Dr, Suite C300, Greenville, SC 29615 USA.
EM robklein63@gmail.com
CR Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
   Bradbury S, 2015, ADV WOUND CARE, V4, P346, DOI 10.1089/wound.2014.0596
   Delhougne G, 2018, OSTOMY WOUND MANAG, V64, P26
   Fong KD, 2010, WOUNDS, V22, P230
   Fout B, 2022, ADV SKIN WOUND CARE, V35, P37, DOI 10.1097/01.ASW.0000801536.61163.e5
   Klein RJ, 2021, WOUNDS, V33, pE75, DOI 10.25270/wnds/2021.e7578
   Lerman B, 2010, PLAST RECONSTR SURG, V126, P1253, DOI 10.1097/PRS.0b013e3181ea4559
   Lim XX, 2021, J WOUND CARE, V30, P1006, DOI 10.12968/jowc.2021.30.12.1006
   Marston WA, 2015, ADV WOUND CARE, V4, P75, DOI 10.1089/wound.2014.0575
   Sen CK, 2019, ADV WOUND CARE, V8, P39, DOI 10.1089/wound.2019.0946
   Swoboda Laura, 2021, Wounds, V33, pE85, DOI 10.25270/wnds/2021.e85e89
   Tettelbach W, 2019, WOUNDS
NR 12
TC 0
Z9 0
U1 2
U2 7
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD MAY
PY 2023
VL 69
IS 2
BP 26
EP 31
DI 10.25270/wmp.2023.2.22087
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA J4YQ1
UT WOS:001009693300003
PM 37253701
DA 2026-07-24
ER
PT J
AU Napolitano, RJ Jr
AF Napolitano Jr., Ralph J.
TI Negative Pressure Wound Therapy with Instillation in Lower Extremity
   Wounds May Contribute to Cost- Savings: 4 Case Reports
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Wound Management; Wound Care; Negative Pressure Wound Therapy
ID DWELL TIME; MANAGEMENT; OUTCOMES; CARE
AB Background: Use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) can assist with wound bed preparation for successful closure. The authors present their experience using NPWTi-d to manage lower extremity wounds in 4 patients and discuss the feasibility of improving cost efficiency. Methods: NPWTi-d involved instillation of normal saline with an 8-to 10 minute dwell time, followed by 3 to 3.5 hours of-125 mm Hg. Therapy continued for 6 to 7 days with dressing changes every 2 to 3 days. Results: Patients were all male, between the ages of 24 and 83 years old. Wound etiologies included chemical burn, deep tissue laceration, compartment syndrome with hematoma, and diabetic foot osteomyelitis. All wounds required cleansing. Prior to NPWTi-d, surgical debridement and antibiotics were administered as necessary. After NPWTi-d, the wounds exhibited healthy granulation and reduced in size, allowing for discharge to outpatient care. Upon follow-up 2 to 6 months later, no patients experienced wound complications or required readmission to the operating room, potentially saving on time and cost. Conclusion: In these patients, use of NPWTi-d assisted in cleansing the wound surface and producing a positive healing outcome. Despite higher initial costs of NPWTi-d over standard dressings, a wound management protocol including NPWTi-d may help mitigate expenses incurred by delayed healing.
C1 [Napolitano Jr., Ralph J.] OrthoNeuro, Columbus, OH USA.
   [Napolitano Jr., Ralph J.] Ohio Univ, Heritage Coll Osteopath Med, Dublin, OH USA.
   [Napolitano Jr., Ralph J.] 191 W Union St, Athens, OH 45701 USA.
C3 University System of Ohio; Ohio University
RP Napolitano, RJ Jr (通讯作者)，191 W Union St, Athens, OH 45701 USA.
EM drralph@newalbanydpm.com
CR Anchalia Manjulata, 2020, Wounds, V32, pE84
   Atiyeh BS, 2009, INT WOUND J, V6, P420, DOI 10.1111/j.1742-481X.2009.00639.x
   Barillo DJ, 2004, BURNS, V30, P448, DOI 10.1016/j.burns.2004.01.032
   Faust E, 2021, PLAST RECONSTR SURG, V147, p16S, DOI 10.1097/PRS.0000000000007607
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   Gabriel A, 2021, PLAST RECONSTR SURG, V147, p68S, DOI 10.1097/PRS.0000000000007614
   Gabriel Allen, 2014, Eplasty, V14, pe41
   Health Forum, 2019, AHA HOSP STAT TM
   Isaac DL, 2020, WOUNDS, V32, P118
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   Kim PJ, 2020, INT WOUND J, V17, P1194, DOI 10.1111/iwj.13424
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2018, WOUNDS, pS1
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Latouche V, 2020, J WOUND CARE, V29, P248, DOI 10.12968/jowc.2020.29.4.248
   Lavery LA, 2020, CLIN INFECT DIS, V70, P1573, DOI 10.1093/cid/ciz489
   Lollo Loreto, 2016, Int J Crit Illn Inj Sci, V6, P133, DOI 10.4103/2229-5151.190648
   Percival SL, 2015, J WOUND CARE, V24, P498, DOI 10.12968/jowc.2015.24.11.498
   Singh P, 2017, ANN ROY COLL SURG, V99, P637, DOI 10.1308/rcsann.2017.0137
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
   Willmore J, 2021, J WOUND CARE, V30, P994, DOI 10.12968/jowc.2021.30.12.994
   Wukich DK, 2016, FOOT ANKLE INT, V37, P1285, DOI 10.1177/1071100716664364
   Yang CK, 2015, J VASC SURG, V61, P995, DOI 10.1016/j.jvs.2014.11.076
NR 23
TC 1
Z9 2
U1 1
U2 3
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD MAY
PY 2023
VL 69
IS 2
BP 32
EP 38
DI 10.25270/wmp.2023.2.22058
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA J4YQ1
UT WOS:001009693300004
PM 37253702
DA 2026-07-24
ER
PT J
AU Fair, L
   Ward, M
   Vankina, M
   Rana, R
   McGowan, T
   Ogola, G
   Aladegbami, B
   Leeds, S
AF Fair, Lucas
   Ward, Marc
   Vankina, Meghana
   Rana, Rashmeen
   McGowan, Titus
   Ogola, Gerald
   Aladegbami, Bola
   Leeds, Steven
TI Comparison of long-term quality of life outcomes between endoscopic
   vacuum therapy and other treatments for upper gastrointestinal leaks
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Endoscopic vacuum therapy; EVAC; Endoluminal vacuum therapy; EVT;
   Quality of life; Gastrointestinal complications
ID SLEEVE GASTRECTOMY; ADVANCING AGE; ESOPHAGECTOMY; JEJUNOSTOMY;
   MANAGEMENT; IMPACT
AB Background While endoscopic vacuum assisted closure (EVAC) therapy is a validated treatment for gastrointestinal leaks, its impact on long-term quality of life (QoL) is uncertain. The purpose of this study was to evaluate the impact of successful EVAC management on long-term QoL outcomes.Methods An institutional review board approved prospectively maintained database was retrospectively reviewed to identify patients undergoing treatment for gastrointestinal leaks between June 2012 and July 2022. The Short-Form 36 (SF-36) survey was used to assess QoL. Patients were contacted by telephone and sent the survey electronically. QoL outcomes between patients who underwent successful EVAC therapy and those who required conventional treatment (CT) were analyzed and compared.Results A total of 44 patients (17 EVAC; 27 CT) completed the survey and were included in our analysis. All included patients had foregut leaks with sleeve gastrectomy being the most common sentinel operation (n = 20). The mean time from the sentinel operation was 3.8 years and 4.8 years for the EVAC and CT groups, respectively. When evaluating long-term QoL, the EVAC group scored higher in all QoL domains when compared to the CT group with physical functioning (87.3 vs 69.3, p = 0.04), role limitations due to physical health (84.1 vs 45.7, p = 0.02), energy/fatigue (60.0 vs 40.9, p = 0.04), and social functioning (86.2 vs 64.1, p = 0.04) reaching statistical significance. Overall, patients who achieved organ preservation via successful EVAC therapy scored higher in all domains with role limitations due to physical health (p = 0.04) being statistically significant. In a multivariable regression analysis, increased age and a history of prior abdominal surgery at the time of the sentinel operation were patient characteristics that negatively impacted QoL outcomes.Conclusion Patients with gastrointestinal leaks successfully managed by EVAC therapy have better long-term QoL outcomes when compared to patients undergoing other treatments.
   [GRAPHICS]
C1 [Fair, Lucas; Ward, Marc; Aladegbami, Bola; Leeds, Steven] Baylor Univ, Dept Minimally Invas Surg, Med Ctr, 3417 Gaston Ave,Suite 965, Dallas, TX 75246 USA.
   [Fair, Lucas; Ward, Marc; Aladegbami, Bola; Leeds, Steven] Baylor Scott & White Hlth, Ctr Adv Surg, Dallas, TX 75246 USA.
   [Ward, Marc; Vankina, Meghana; Aladegbami, Bola; Leeds, Steven] Texas A&M Coll Med, Bryan, TX 77807 USA.
   [Fair, Lucas; Rana, Rashmeen; McGowan, Titus; Ogola, Gerald] Baylor Scott & White Hlth, Res Inst, Dallas, TX USA.
C3 Baylor University; Baylor University Medical Center; Baylor Scott &
   White Health; Texas A&M University System; Texas A&M University College
   Station; Texas A&M Health Science Center; Baylor Scott & White Health
RP Leeds, S (通讯作者)，Baylor Univ, Dept Minimally Invas Surg, Med Ctr, 3417 Gaston Ave,Suite 965, Dallas, TX 75246 USA.; Leeds, S (通讯作者)，Baylor Scott & White Hlth, Ctr Adv Surg, Dallas, TX 75246 USA.; Leeds, S (通讯作者)，Texas A&M Coll Med, Bryan, TX 77807 USA.
EM Steven.leeds@bswhealth.org
RI Rana, Rafquat/AFZ-7483-2022
OI Fair, Lucas/0000-0002-6082-5827; McGowan, Titus/0009-0008-9503-6220
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NR 36
TC 3
Z9 3
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD AUG
PY 2023
VL 37
IS 8
BP 6538
EP 6547
DI 10.1007/s00464-023-10181-z
EA JUN 2023
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA L4YJ0
UT WOS:001009731600006
PM 37308758
DA 2026-07-24
ER
PT J
AU Montgomery, A
   van Eeden, L
   Boo, M
   Maul, K
   de Silva, K
   Klasan, A
   Sedgwick, PM
   Eva, L
   Bergzoll, C
AF Montgomery, Alison
   van Eeden, Lulu
   Boo, Marilyn
   Maul, Kayleigh
   de Silva, Karl
   Klasan, Antonio
   Sedgwick, Philip Martin
   Eva, Lois
   Bergzoll, Cecile
TI Does Closed Incision Negative Pressure Wound Therapy Reduce Surgical
   Site Infection in Endometrial Carcinoma Patients Undergoing Laparotomy?
   A Multicentre Retrospective Cohort Study
SO CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
LA English
DT Article
DE surgical site infection; negative pressure wound therapy; endometrial
   carcinoma
ID SURGERY; VACUUM
AB Background: Endometrial cancer is the most common gynaecological cancer and has a strong association with obesity. Surgical site infection (SSI) carries high morbidity and is more frequent in obese patients. Closed incision negative pressure wound therapy (ciNPWT) has been proposed to reduce wound morbidity but is more expensive than standard dressings whilst the evidence has been very heterogenous. There is limited evidence to justify this expensive dressing as related to its effectiveness in gynaecological oncology patients. ciNPWT was introduced in New Zealand in 2017 based on the available evidence from studies on SSI in the obstetric population. The aim of this study is to investigate the rate of SSI in patients with endometrial carcinoma undergoing laparotomy using standard surgical dressings compared to ciNPWT. Methods: We performed a retrospective analysis of 170 patients who underwent a laparotomy for endometrial carcinoma between 2018 and 2019 across three hospitals in New Zealand after the introduction of ciNPWT. Dressings were applied according to individual surgeons' preferences. Standard dressings and ciNPWT were compared in the occurrence of SSI, wound dehiscence, readmission and return to theatre rates using logistic regression in order to account for potential confounding due to the patient demographics and oncologic and surgical characteristics. Results: There were 129 patients in the standard dressing group and 41 patients in the ciNPWT group. The mean age was 60.4 years (range 25-86). The mean body mass index (BMI) was 38.2 kg/m2 (range 20-69 kg/m2). The percentage of patients who experienced a SSI was higher in the ciNPWT group (34.2% vs. 20.9%; p = 0.159). There was no significant difference between the dressing groups in the occurrence of superficial SSI rate, return to theatre, or readmission. Wound dehiscence and deep/organ space SSI were however worse with ciNPWT (adjusted odds ratio (aOR) 4.09 and aOR 7.19, respectively). Conclusions: This study demonstrated no evidence for the benefit of ciNPWT, and higher rates of deep/organ space SSI. More randomised trials are needed to investigate whether gynaecological oncology patients may benefit from ciNPWT thus justifying the extra cost of this dressing.
C1 [Montgomery, Alison] St Michaels Hosp, Gynaecol Dept, Bristol BS2 8EG, Avon, England.
   [van Eeden, Lulu; de Silva, Karl] Middlemore Hosp, Obstet & Gynaecol Dept, Auckland 2025, New Zealand.
   [Boo, Marilyn] Westmead Hosp, Gynaecol Oncol Dept, Westmead, NSW 2145, Australia.
   [Maul, Kayleigh] Northshore Hosp, Obstet & Gynaecol Dept, Auckland 0620, New Zealand.
   [Klasan, Antonio] AUVA Hosp, Orthopaed Dept, A-8020 Graz, Austria.
   [Sedgwick, Philip Martin] St Georges Univ London, Inst Med & Biomed Educ, London SW17 0RE, England.
   [Eva, Lois; Bergzoll, Cecile] Auckland City Hosp, Gynaecol Oncol Dept, Auckland 1023, New Zealand.
C3 NSW Health; Westmead Hospital; University of Sydney; City St Georges,
   University of London; Auckland City Hospital
RP Montgomery, A (通讯作者)，St Michaels Hosp, Gynaecol Dept, Bristol BS2 8EG, Avon, England.
EM alison.montgomery3@nhs.net
RI Sedgwick, Philip/C-6997-2019; Klasan, Antonio/S-6201-2019; Sedgwick,
   Philip Martin/C-6997-2019
OI Sedgwick, Philip Martin/0000-0001-8859-2175; Eva,
   Lois/0000-0002-4239-0313
CR 3M+KCI, 2020, PREV INC MAN SYST
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NR 31
TC 2
Z9 2
U1 1
U2 3
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0390-6663
EI 2709-0094
J9 CLIN EXP OBSTET GYN
JI Clin. Exp. Obstet. Gynecol.
PD MAY
PY 2023
VL 50
IS 5
AR 102
DI 10.31083/j.ceog5005102
PG 12
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA J6HV4
UT WOS:001010613500013
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Robbins, JM
   Courtney, J
   Hingorani, A
AF Robbins, Justin M.
   Courtney, James
   Hingorani, Anil
TI Systematic review of groin incision surgical site infection preventative
   measures in vascular surgery
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Review
DE Surgical site infection; Groin; Inguinal; Prevention; Vascular surgery
ID PRESSURE WOUND THERAPY; PROPHYLACTIC MUSCLE FLAPS; METAANALYSIS;
   COMPLICATIONS; TRANSVERSE; PREVENTION; EXPERIENCE; IMPACT
AB Objective: Groin surgical site infections (SSIs) after open revascularization can lead to devastating consequences in patients. As a result, prevention has been crucial in minimizing the rate of SSIs. This review aims to evaluate the current body of literature regarding prevention,techniques including prophylactic flaps, incision technique, topical antibiotic use, closed-incision negative pressure wound therapy, and adhesive drapes.
   Methods: This review was conducted and reported in accordance with the PRISMA statement. A systematic review was conducted using the Google Scholar, PubMed, and Cochrane Review databases regarding the five prevention topics. The authors identified 1371 potential studies with 33 studies selected and analyzed after systematic review regarding the five preventative topics.
   Results: The primary outcome of interest was how the rate of SSI was affected with each preventative technique. As a result, the recommendations are as follows. We suggest prophylactic flaps be considered in high-risk surgical patients undergoing open arterial exposure of the groin (Grade 2C). We suggest consideration of transverse incisions for open arterial exposure of the groin as a means of SSI prevention (Grade 2C). Given the lack of data regarding topical antibiotics no recommendation can be made regarding its use, we suggest closed-incision negative pressure wound therapy be used in groin surgical incisions at high risk for SSI (Grade 2B). Given the paucity of data regarding adhesive drapes, such as Ioban, no recommendation can be made regarding its use.
   Conclusions: This review highlights the effects of various preventative techniques and their potential benefit in the prevention of SSI in the groin. However, there is a glaring deficit in the available data, emphasizing the need for additional robust studies to better delineate their effectiveness and implementation into surgical practice. The use of endovascular techniques continues to increase, thus limiting the number of open arterial procedures and the potential for further studies to be conducted. To provide the high-quality studies needed to better evaluate these prevention techniques, large multi-institutional collaboration will likely be necessary to provide the appropriate number of patients to evaluate true effectiveness.
C1 [Robbins, Justin M.] Wright State Univ, Dept Gen Surg, Boonshoft Sch Med, Dayton, OH USA.
   [Courtney, James] Florida State Univ, Coll Med, Tallahassee, FL USA.
   [Hingorani, Anil] NUY Langone Brooklyn, Div Vasc Surg, Brooklyn, NY USA.
   [Robbins, Justin M.] Wright State Univ, Dept Surg, 128 E Apple St,Ste WB7000, Dayton, OH 45409 USA.
C3 University System of Ohio; Wright State University Dayton; State
   University System of Florida; Florida State University; University
   System of Ohio; Wright State University Dayton
RP Robbins, JM (通讯作者)，Wright State Univ, Dept Surg, 128 E Apple St,Ste WB7000, Dayton, OH 45409 USA.
EM jmrobbins94@gmail.com
OI Robbins, Justin/0000-0002-1643-2698
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NR 43
TC 15
Z9 16
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD JUN
PY 2023
VL 77
IS 6
BP 1836
EP +
DI 10.1016/j.jvs.2023.01.209
EA MAY 2023
PG 18
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA J9XV9
UT WOS:001013092300001
PM 36804782
OA Bronze
DA 2026-07-24
ER
PT J
AU Tian, YL
   Li, K
   Zeng, L
AF Tian, Yali
   Li, Ka
   Zeng, Ling
TI A systematic review with meta-analysis on prophylactic negative pressure
   wound therapy versus standard dressing for obese women after caesarean
   section
SO NURSING OPEN
LA English
DT Review
DE caesarean section; meta-analysis; negative-pressure wound therapy;
   nursing care; obesity; randomized controlled trial
ID SURGICAL-SITE INFECTION; PREPREGNANCY OBESITY; MATERNAL AGE; DELIVERY;
   COST; RISK; COMPLICATIONS; PREGNANCY; INCISION; OUTCOMES
AB AimsThe purpose of this study is to assess the efficacy of prophylactic negative pressure wound therapy (NPWT) in obese women undergoing caesarean section. DesignAn updated review and meta-analysis of randomized controlled trials following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. MethodsPubMed, Embase, Medline, Web of Science, and Cochrane Library were searched from inception up to March 2022 without restriction in language. We chose surgical site infection as the primary outcome. ResultsNPWT resulted in a lower surgical site infection rate compared with conventional dressing (risk ratio [RR] = 0.76). The infection rate after low transverse incision was lower comparing the NPWT group with the control group ([RR] = 0.76). No statistically significant difference was detected in blistering([RR] = 2.91). The trial sequential analysis did not support the 20% relative decrease in surgical site infection in the NPWT group. (type II error of 20%).
C1 [Tian, Yali; Li, Ka] Sichuan Univ, West China Hosp, West China Sch Nursing, Chengdu, Peoples R China.
   [Zeng, Ling] Sichuan Univ, West China Hosp, West China Sch Nursing, Dept Crit Care Med, Chengdu, Peoples R China.
   [Li, Ka; Zeng, Ling] Sichuan Univ, 37 Guoxue Alley, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University
RP Li, K; Zeng, L (通讯作者)，Sichuan Univ, 37 Guoxue Alley, Chengdu, Sichuan, Peoples R China.
EM lika127@126.com; zengling510@163.com
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NR 75
TC 5
Z9 7
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2054-1058
J9 NURS OPEN
JI NURS. OPEN
PD SEP
PY 2023
VL 10
IS 9
BP 5999
EP 6013
DI 10.1002/nop2.1912
EA JUN 2023
PG 15
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA W7DY2
UT WOS:001013370400001
PM 37365685
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ockerman, KM
   Cox, EA
   Wiesemann, G
   Nichols, DS
   Murad, GJA
   Ching, J
   Sorice-Virk, S
AF Ockerman, Kyle M.
   Cox, Elizabeth A.
   Wiesemann, Gayle
   Nichols, D. Spencer
   Murad, Gregory J. A.
   Ching, Jessica
   Sorice-Virk, Sarah
TI Healing Exposed Calvarial Hardware Using Negative-Pressure Wound Therapy
   and Vashe Wound Solution: Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE cranial reconstruction; cranioplasty; hypochlorous acid solution;
   infection; syndrome of the trephined; vacuum-assisted closure; Vashe
   Wound Solution
ID CRANIOPLASTY; INFECTIONS; MANAGEMENT; FLAP
AB OBJECTIVEThe management of cranioplasty infections has historically been explantation followed by delayed reimplantation/reconstruction. This treatment algorithm necessitates surgery, tissue expansion, and prolonged disfigurement. In this report, the authors describe a treatment approach consisting of serial vacuum-assisted closure (VAC) with hypochlorous acid (HOCl) solution (Vashe Wound Solution; URGO Medical) as a salvage strategy.METHODSA 35-year-old man who sustained head trauma, neurosurgical complications, and severe syndrome of the trephined (SOT; devastating neurologic decline treated by cranioplasty) underwent titanium cranioplasty with free flap. Three weeks postoperation, he presented with pressure-related wound dehiscence/partial flap necrosis, exposed hardware, and bacterial infection. Given the severity of his precranioplasty SOT, hardware salvage was critical. He was treated with serial VAC with HOCl solution for 11 days followed by VAC for 18 days and definitive split-thickness skin graft placement over resulting granulation tissue. Authors also conducted a literature review of cranial reconstruction infection management.RESULTSThe patient remained healed 7 months postoperatively without recurrent infection. Importantly, his original hardware was retained, and his SOT remained resolved. Findings from the literature review support the use of conservative modalities to salvage cranial reconstructions without hardware removal.CONCLUSIONSThis study investigates a new strategy for managing cranioplasty infections. The VAC with HOCl solution regimen was effective in treating the infection and salvaging the cranioplasty, thus obviating the complications associated with explantation, new cranioplasty, and recurrence of SOT. There is limited literature on the management of cranioplasty infections using conservative treatments. A larger study to better determine the efficacy of VAC with HOCl solution is underway.
C1 [Ockerman, Kyle M.; Wiesemann, Gayle] Univ Florida, Coll Med, Gainesville, FL 32610 USA.
   [Murad, Gregory J. A.] Univ Florida, Coll Med, Dept Neurosurg, Gainesville, FL USA.
   [Ching, Jessica; Sorice-Virk, Sarah] Univ Florida, Coll Med, Div Plast & Reconstruct Surg, Gainesville, FL USA.
   [Cox, Elizabeth A.] Stanford Univ, Sch Med, Div Plast & Reconstruct Surg, Palo Alto, CA USA.
   [Nichols, D. Spencer] Duke Univ, Sch Med, Div Plast & Reconstruct Surg, Durham, NC USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; State University
   System of Florida; University of Florida; Stanford University; Duke
   University
RP Ockerman, KM (通讯作者)，Univ Florida, Coll Med, Gainesville, FL 32610 USA.
OI Nichols, D. Spencer/0000-0003-4657-7844; Ockerman,
   Kyle/0000-0002-6500-6740
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NR 32
TC 2
Z9 2
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUL
PY 2023
VL 36
IS 7
BP 385
EP 391
DI 10.1097/01.ASW.0000926628.10995.fc
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA K3DP2
UT WOS:001015279500012
PM 37224465
DA 2026-07-24
ER
PT J
AU Alemdar, A
   Egin, S
AF Alemdar, Ali
   Egin, Seracettin
TI Improvement of Three Duodenal Re-leaks: Two-way Vacuum-assisted Closure
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Open abdomen; Vacuum-assisted closure; Severe peritonitis; Duodenal leak
AB We share our experience of a two-way vacuum-assisted closure (VAC) technique that allows patients to heal when generalised peritonitis develops because of a recurrent duodenal leak. Two patients underwent omentoplasty for duodenal ulcer perforation and one patient underwent antrectomy, gastrojejunostomy, and tube duodenostomy. Two-way VAC was performed by taking an abdominal fluid culture and washing the abdomen with 6-12 litres of warm saline. Two-way VAC exchange procedures were continued every 3 days and total parenteral nutrition was administered until cessation of the duodenal re-leak. The two-way VAC application was terminated when improvement in the re-leak was macroscopically detected. The subcutaneous layer was dissected from the anterior abdominal wall fascial layer, and the abdominal skin was closed without tension. The patients were subsequently discharged. Controlling the primary source is often difficult when treating duodenal re-leaks, and two-way VAC can localise the source of the peritonitis and remove toxic peritoneal material.
C1 [Alemdar, Ali; Egin, Seracettin] Univ Hlth Sci, Okmeydani Educ & Res Hosp, Dept Surg, Istanbul, Turkey.
C3 Istanbul Okmeydani Training & Research Hospital; University of Health
   Sciences Turkey
RP Egin, S (通讯作者)，Univ Hlth Sci, Okmeydani Educ & Res Hosp, Dept Surg, Istanbul, Turkey.
EM seracettin_egin@hotmail.com
RI Alemdar, Ali/HKV-6078-2023; Eğin, Seracettin/GQZ-0908-2022
CR Chalya PL, 2011, WORLD J EMERG SURG, V6, DOI 10.1186/1749-7922-6-31
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
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   Sartelli M, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0032-7
NR 5
TC 0
Z9 0
U1 0
U2 0
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD APR
PY 2022
VL 32
SU S
BP 15
EP 17
DI 10.29271/jcpsp.2022.JCPSPCR.CR15
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA K8OP5
UT WOS:001018979100006
DA 2026-07-24
ER
PT J
AU Ulusoy, S
   Kilinç, I
   Oruç, M
   Özdemir, B
   Ergani, HM
   Keskin, ÖH
   Özdemir, G
AF Ulusoy, Serap
   Kilinc, Ibrahim
   Oruc, Mustafa
   Ozdemir, Buket
   Ergani, Hasan Murat
   Keskin, Omer Halit
   Ozdemir, Guzelali
TI Analysis of wound types and wound care methods after the 2023
   Kahramanmaras earthquake
SO JOINT DISEASES AND RELATED SURGERY
LA English
DT Article
DE Collapsed buildings; earthquake; musculoskeletal injury; wound care
   wound
ID VACUUM-ASSISTED CLOSURE; MUSCULOSKELETAL INJURIES; HYPOCHLOROUS ACID;
   MANAGEMENT; THERAPY; REPAIR; OXYGEN
AB Objectives: This study aims to investigate the types of wounds and wound care in earthquake victims rescued from collapsed buildings after the 2023 Kahramanmaras earthquake.Patients and methods: Between February 8th, 2023 and March 1st, 2023, a total of 94 patients (46 males, 48 females; mean age: 40.2 & PLUSMN;15.5 years; range, 16 to 77 years) with earthquake-related wounds who were trapped under rubble were retrospectively analyzed. Data including age, sex, duration of being trapped under rubble, type and location of the wound, bacterial cultures from deep tissue, and wound care methods used were recorded.Results: The mean duration of being trapped under rubble was 58 & PLUSMN;38.1 h. Wounds were most commonly located on the lower extremities, followed by the upper extremities. The most common type of wounds were abrasions, followed by necrotic wounds due to crushing. Wound and skin antiseptics, debridement and negative pressure wound therapy (NPWT) were the most common wound care methods used.Conclusion: Various types of injuries and wounds may occur after natural disasters. Chronic wound care is as important as the management of life-threatening acute pathologies. Preparations should be made properly for the long-term treatment of patients after disasters. Methods such as NPWT, debridement creams containing collagenase, wound and skin antiseptics, and hyperbaric oxygen therapy can provide satisfactory short-term results. A broader and more intense application of these treatments is thought to be beneficial, particularly in crush injuries.
C1 [Ulusoy, Serap; Kilinc, Ibrahim; Oruc, Mustafa; Ozdemir, Buket] Ankara Bilkent City Hosp, Dept Gen Surg, Ankara, Turkiye.
   [Ergani, Hasan Murat] Univ Hlth Sci, Ankara Bilkent City Hosp, Dept Plast Reconstruct & Aesthet Surg, Ankara, Turkiye.
   [Keskin, Omer Halit; Ozdemir, Guzelali] Ankara Bilkent City Hosp, Dept Orthoped & Traumatol, Ankara, Turkiye.
C3 University of Health Sciences Turkey
RP Ulusoy, S (通讯作者)，Ankara Bilkent Sehir Hastanesi, Gen Cerrahi Klin, TR-06800 Ankara, Turkiye.
EM serapulusoy13@gmail.com
RI Ulusoy, Serap/JBS-7863-2023; Ergani, Hasan Murat/ADG-1790-2022; Keskin,
   Omer Halit/JNR-9917-2023; Oruc, Mustafa/LXW-0152-2024; Ozdemir,
   Guzelali/LBH-4760-2024; Özdemir Ulusoy, Bahar/ITU-9764-2023
OI Ulusoy, Serap/0000-0001-9014-7070; Ergani, Hasan
   Murat/0000-0002-0305-7032; Keskin, Omer Halit/0000-0003-2402-8465; Oruc,
   Mustafa/0000-0002-7918-1689; ALTUN ÖZDEMİR, BUKET/0000-0002-1043-8108; 
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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   Sibbald RG, 2021, ADV SKIN WOUND CARE, V34, P183, DOI 10.1097/01.ASW.0000733724.87630.d6
   Siegel HJ, 2014, CLIN ORTHOP RELAT R, V472, P830, DOI 10.1007/s11999-013-3123-3
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NR 36
TC 16
Z9 20
U1 0
U2 2
PU TURKISH JOINT DISEASES FOUNDATION
PI CANKAYA
PA MUSTAFA KEMAL MAHALLESI, DUMLUPINAR BULVARI 274-2 C2 BLOK OFIS, 5,
   CANKAYA, ANKARA, TURKEY
EI 2687-4792
J9 JOINT DIS RELAT SURG
JI Joint Dis. Relat. Surg.
PY 2023
VL 34
IS 2
BP 488
EP 496
DI 10.52312/jdrs.2023.1128
PG 9
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA K9EW5
UT WOS:001019406000034
PM 37462657
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kiliçarslan, K
   Erdogan, Y
   Karaman, Y
   Alkan, H
   Biçici, V
AF Kilicarslan, Kasim
   Erdogan, Yasin
   Karaman, Yavuz
   Alkan, Hilmi
   Bicici, Vedat
TI Comparison of dermatotraction and negative pressure wound therapy for
   closure of cruris fasciotomy after 2023 Kahramanmaras earthquake
SO JOINT DISEASES AND RELATED SURGERY
LA English
DT Article
DE Acute compartment syndrome; dermatotraction earthquake; fasciotomy;
   negative pressure wound therapy
ID DELAYED PRIMARY CLOSURE; VACUUM-ASSISTED CLOSURE; LOWER LEG; COMPARTMENT
AB Objectives: This study aims to evaluate the results of patients who underwent cruris fasciotomy for acute compartment syndrome (ACS) after the 2023 Kahramanmaras earthquake and used subcuticular polydioxanone (PDS) method or negative pressure wound therapy (NPWT) with vacuum-assisted closure (VAC) for fasciotomy follow-up and closure of the defect. Patients and methods: Between March 2023 and April 2023, a total of 52 patients (31 males, 21 females; mean age: 29 & PLUSMN;14.8 years; range, 5 to 74 years) were retrospectively analyzed. The patients were divided into two groups as the dermatotraction (PDS) group (Group 1, n=30), and the VAC group (Group 2, n=22). Data including demographic, clinical, and operative data such as fasciotomy closure time, graft need, and infection rate were recorded. Results: More grafts were needed to close the fasciotomy in patients followed with VAC. The mean closure time of the fasciotomy was 25.9 & PLUSMN;3.8 days in the PDS group and 27.3 & PLUSMN;3.5 days in the VAC group, indicating no significant difference between the groups (p=0.738). There was no significant difference in the rate of wound infection between the two groups (p=0.482). Conclusion: Our study results suggest that more grafts are needed to close the fasciotomy in patients followed with VAC; however, it seems to increase the cost of the treatment.
C1 [Kilicarslan, Kasim; Karaman, Yavuz; Alkan, Hilmi; Bicici, Vedat] Ankara Bilkent City Hosp, Dept Orthoped & Traumatol, Ankara, Turkiye.
   [Erdogan, Yasin] Ankara Yildirim Beyazit Univ, Dept Orthoped & Traumatol, Ankara, Turkiye.
C3 Ankara Yildirim Beyazit University
RP Kiliçarslan, K (通讯作者)，Ankara Bilkent Sehir Hastanesi, Ortopedi & Travmatol Klin, TR-06800 Ankara, Turkiye.
EM kilicarslan44@hotmail.com
RI ; Alkan, Hilmi/HKW-2381-2023; ERDOĞAN, YASİN/KHU-8043-2024; Kilicarslan,
   Kasim/IAO-0071-2023
OI KARAMAN, YAVUZ/0000-0002-6651-1212; Alkan, Hilmi/0000-0002-5451-4678;
   ERDOĞAN, YASİN/0000-0001-6862-9671; 
CR Atik OS, 2022, JOINT DIS RELAT SURG, V33, P1, DOI 10.52312/jdrs.2022.57903
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NR 22
TC 6
Z9 8
U1 0
U2 1
PU TURKISH JOINT DISEASES FOUNDATION
PI CANKAYA
PA MUSTAFA KEMAL MAHALLESI, DUMLUPINAR BULVARI 274-2 C2 BLOK OFIS, 5,
   CANKAYA, ANKARA, TURKEY
EI 2687-4792
J9 JOINT DIS RELAT SURG
JI Joint Dis. Relat. Surg.
PY 2023
VL 34
IS 2
BP 497
EP 502
DI 10.52312/jdrs.2023.1119
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA K9EW5
UT WOS:001019406000035
PM 37462658
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sapci, I
   Camargo, M
   Duraes, L
   Jia, X
   Hull, TL
   Ashburn, J
   Valente, MA
   Holubar, SD
   Delaney, CP
   Gorgun, E
   Steele, SR
   Liska, D
AF Sapci, Ipek
   Camargo, Mariane
   Duraes, Leonardo
   Jia, Xue
   Hull, Tracy L.
   Ashburn, Jean
   Valente, Michael A.
   Holubar, Stefan D.
   Delaney, Conor P.
   Gorgun, Emre
   Steele, Scott R.
   Liska, David
TI Effect of Incisional Negative Pressure Wound Therapy on Surgical Site
   Infections in High-Risk Reoperative Colorectal Surgery: A Randomized
   Controlled Trial
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Society-of-Colon-and-Rectal-Surgeons
CY APR 24-28, 2021
CL San Diego, CA
SP Amer Soc Colon & Rectal Surg
DE Negative pressure wound therapy; Reoperative colorectal surgery;
   Surgical site infection
ID CARE IMPROVEMENT PROJECT; LAPAROTOMY; PREVENTION; IMPACT
AB BACKGROUND: Colorectal resections have relatively high rates of surgical site infections causing significant morbidity. Incisional negative pressure wound therapy was introduced to improve wound healing of closed surgical incisions and to prevent surgical site infections.
   OBJECTIVE: This randomized controlled trial aimed to investigate the effect of incisional NPWT on superficial surgical site infections in high-risk, open, reoperative colorectal surgery.
   DESIGN: This was a single-center randomized controlled trial conducted between July 2015-October 2020. Patients were randomly assigned to incisional negative pressure wound therapy or standard gauze dressing with a 1:1 ratio. A total of 298 patients were included.
   SETTINGS: This study was conducted at the colorectal surgery department of a tertiary-level hospital.
   PATIENTS: This study included patients older than 18 years who underwent elective reoperative open colorectal resections. Patients were excluded who had open surgery within the past 3 months, who had active surgical site infection, and who underwent laparoscopic procedures.
   MAIN OUTCOME MEASURES: The primary outcome was superficial surgical site infection within 30 days. Secondary outcomes were deep and organ-space surgical site infections within 7 days and 30 days, postoperative complications, and length of hospital stay.
   RESULTS: A total of 149 patients were included in each arm. The mean age was 51 years, and 49.5% were women. Demographics, preoperative comorbidities, and preoperative albumin levels were comparable between the groups. Overall, most surgeries were performed for IBD, and 77% of the patients had an ostomy fashioned during the surgery. No significant difference was found between the groups in 30-day superficial surgical site infection rate (14.1% in control versus 9.4% in incisional negative pressure wound therapy; p = 0.28). Deep and organ-space surgical site infections rates at 7 and 30 days were also comparable between the groups. Postoperative length of stay and complication rates (Clavien-Dindo grade) were also comparable between the groups.
   LIMITATIONS: The patient population included in the trial consisted of a selected group of high-risk patients.
   CONCLUSIONS: Incisional negative pressure wound therapy was not associated with reduced superficial surgical site infection or overall complication rates in patients undergoing high-risk reoperative colorectal resections. See Video Abstract at http://links.lww.com/DCR/B956.
C1 [Sapci, Ipek; Camargo, Mariane; Duraes, Leonardo; Jia, Xue; Hull, Tracy L.; Ashburn, Jean; Valente, Michael A.; Holubar, Stefan D.; Delaney, Conor P.; Gorgun, Emre; Steele, Scott R.; Liska, David] Cleveland Clin, Digest Dis & Surg Inst, Dept Colorectal Surg, 9500 Euclid Ave,Desk A-30, Cleveland, OH 44106 USA.
C3 Cleveland Clinic Foundation
RP Liska, D (通讯作者)，Cleveland Clin, Digest Dis & Surg Inst, Dept Colorectal Surg, 9500 Euclid Ave,Desk A-30, Cleveland, OH 44106 USA.
RI Liska, David/L-9180-2019; de Castro Duraes, Leonardo/G-7629-2016;
   Holubar, Stefan/I-3798-2019; Camargo, Mariane/LPP-8946-2024
OI Liska, David/0000-0002-8632-6065; de Castro Duraes,
   Leonardo/0000-0002-9161-5806; 
CR Abadía P, 2021, SURG INFECT, V22, P234, DOI 10.1089/sur.2019.309
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   Nguyen SH, 2021, SURG INFECT, V22, P562, DOI 10.1089/sur.2020.183
   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
   Jiménez JO, 2019, CIR ESPAN, V97, P268, DOI 10.1016/j.ciresp.2019.03.001
   Pastor C, 2010, DIS COLON RECTUM, V53, P24, DOI 10.1007/DCR.0b013e3181ba782a
   Shen P, 2017, J AM COLL SURGEONS, V224, P726, DOI 10.1016/j.jamcollsurg.2016.12.028
   Smith RL, 2004, ANN SURG, V239, P599, DOI 10.1097/01.sla.0000124292.21605.99
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   Wick EC, 2009, DIS COLON RECTUM, V52, P374, DOI 10.1007/DCR.0b013e31819a5e45
NR 30
TC 5
Z9 7
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD FEB
PY 2023
VL 66
IS 2
BP 306
EP 313
DI 10.1097/DCR.0000000000002415
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology; Surgery
GA L3BA4
UT WOS:001022032900026
PM 35358097
DA 2026-07-24
ER
PT J
AU Rather, AA
   Fisher, AL
   Chun, D
   Mannion, JD
   Alexander, EL
AF Rather, Assar A.
   Fisher, Adrianne L.
   Chun, Dain
   Mannion, John D.
   Alexander, Edward L.
TI Closed Incisional Negative Pressure Therapy Reduces Perineal Wound
   Complications After Abdominoperineal Resection
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article; Proceedings Paper
CT Annual Scientific Meeting of the
   American-Society-of-Colon-and-Rectal-Surgeons
CY MAY 19-23, 2018
CL Nashville, TN
SP Amer Soc Colon & Rectal Surg
DE Abdominoperineal resection; Closed incision negative pressure therapy;
   Perineal wound complications
ID VACUUM-ASSISTED CLOSURE; RECTAL-CANCER; RISK-FACTORS; IMPACT; DECREASES
AB BACKGROUND: Perineal wound complications after abdominoperineal resection continue to be a significant challenge. Complications, ranging from 14% up to 60%, prolong hospitalization, increase risk of readmission and reoperation, delay the start of adjuvant therapy, and place psychological stress on the patient and family.
   OBJECTIVE: This study aimed to evaluate the impact of closed incision negative pressure therapy on perineal wound healing.
   DESIGN: This was a retrospective study.
   SETTINGS: The study was conducted in an academic community hospital.
   PATIENTS: Patients who underwent abdominoperineal resection from 2012 to 2020 were included.
   MAIN OUTCOME MEASURES: Perineal wound complications within 30 and 180 days were the primary outcome measures.
   RESULTS: A total of 45 patients were included in the study. Of these, 31 patients were managed with closed incision negative pressure therapy. The overall perineal wound complications were less frequent in the closed incision negative pressure therapy group (10/31; 32.2%) compared to the control group (10/14; 71.4%; chi(2)(1) = 5.99 [p = 0.01]). In the closed incision negative pressure therapy group, 2 patients (20%) did not heal within 180 days and no patient required reoperation or readmission. In the control group, 4 patients (44%) had not healed at 180 days and 1 patient required flap reconstruction. When the effect of other variables was controlled, closed incision negative pressure therapy resulted in an 85% decrease in the odds of wound complications (adjusted OR 0.15 [95% CI, 0.03-0.60]; p = 0.01).
   LIMITATIONS: The nonrandomized nature and use of historical controls in this study are its limitations.
   CONCLUSIONS: The ease of application and the overall reduction in the incidence and severity of complications may offer an option for perineal wound management and possibly obviate the need for more expensive therapies. Further prospective controlled trials are required to effectively study its efficacy. See Video Abstract at http:// links.lww.com/DCR/B895.
C1 [Rather, Assar A.; Chun, Dain] Bayhealth Med Ctr, Grad Med Educ Dept, Dover, DE USA.
   [Rather, Assar A.; Fisher, Adrianne L.; Mannion, John D.; Alexander, Edward L.] Bayhealth Med Ctr, Dept Surg, Dover, DE USA.
   [Rather, Assar A.] Bayhealth Med Ctr, Grad Med Educ Dept, Mail Code 3007,640 S State St, Dover, DE 19901 USA.
RP Rather, AA (通讯作者)，Bayhealth Med Ctr, Grad Med Educ Dept, Mail Code 3007,640 S State St, Dover, DE 19901 USA.
EM Assar_Rather@bayhealth.org
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NR 27
TC 3
Z9 3
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD FEB
PY 2023
VL 66
IS 2
BP 314
EP 321
DI 10.1097/DCR.0000000000002289
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology; Surgery
GA L3BA4
UT WOS:001022032900027
PM 35001048
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Sweitzer, K
   Butterfield, J
   Hubert, J
   Park, W
   Tomtschik, J
   Carter, M
   Gosev, I
   Bell, D
AF Sweitzer, Keith
   Butterfield, James
   Hubert, Jessica
   Park, Won
   Tomtschik, Julia
   Carter, Mathew
   Gosev, Igor
   Bell, Derek
TI Flap Coverage of Infected Ventricular Assist Devices Influences Patient
   Outcomes
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE LVAD; infection; muscle flap; coverage
AB BackgroundThe use of left ventricular assist devices (LVADs) for patients with end-stage cardiac failure awaiting heart transplantation has become increasingly common. However, ventricular assist device-related infections remain a major problem complicating their long-term use. Poor data exist to determine how to manage these infections after operative debridement.MethodsPatients who underwent insertion of a ventricular assist device and had a subsequent readmission for LVAD infection at the University of Rochester Medical Center from 2012 to 2022 were identified through accessing the medical records archives of the hospital. Patients were followed retrospectively for an average of 3.2 years. Patient demographics, preoperative diagnosis/disease state, type of ventricular assist device inserted, postoperative day of ventricular assist device infection onset, infectious organism identified at initial washout, infectious organism identified at time of definitive device coverage, timing of coverage procedure after the initial washout for infection, type of flap used for coverage, 90-day complications after definitive coverage, and lifetime return to operating room for infection were reviewed. Comparison analysis with a & chi;(2) test was used to analyze outcomes.ResultsOf 568 patients admitted with an LVAD-related infection 117 underwent operative debridement. Of these, 34 underwent primary closure, 31 underwent closure with secondary intention (negative pressure wound therapy with split thickness skin grafting), and 52 were closed with a flap (pectoralis, omental, latissimus, or vertical rectus abdominus musculocutaneous flap). There was a statistically significant higher incidence of return to the operating room (RTOR) for infection over a lifetime with primary closure compared with secondary intention and flap reconstruction (P = 0.01, 0.02), but no difference in 90-day complications (P = 0.76, P = 0.58). Eighty-three patients had a positive culture upon definitive coverage with 24 having a postsurgical complication, 15 of which required lifetime RTOR for infection. Thirty four were closed with negative cultures with 9 having a complication and 4 requiring RTOR for infection. This was not statistically significant for complications or RTOR (P = 0.79, 0.40). Culture data were further substratified into bacterial cultures (n = 73) versus fungal cultures (n = 10), and there was no statistically significant difference between these compared with complications or RTOR (P = 0.40, 0.39).ConclusionsCoverage of infected LVADs with locoregional flaps or allowing to granulate using wound vac therapy has a decreased lifetime RTOR for future infections for these patients without increase in 90-day complications. Timing of RTOR should not be impacted by positive cultures provided there is healthy granulation tissue in the wound.
C1 [Sweitzer, Keith; Butterfield, James; Hubert, Jessica; Park, Won; Tomtschik, Julia; Carter, Mathew; Bell, Derek] Univ Rochester, Div Plast Surg, Rochester, NY USA.
   [Gosev, Igor] Univ Rochester, Dept Surg, Div Cardiothorac Surg, Rochester, NY USA.
   [Sweitzer, Keith] Univ Rochester, River Campus,601 Elmwood Ave, Rochester, NY 14642 USA.
C3 University of Rochester; University of Rochester; University of
   Rochester
RP Sweitzer, K (通讯作者)，Univ Rochester, River Campus,601 Elmwood Ave, Rochester, NY 14642 USA.
EM Keithsweitzer6@gmail.com; james_butterfield@URMC.rochester.edu;
   jessica_hubert@urmc.rochester.edu; won_park@urmc.rochester.edu;
   julia_tomtschik@URMC.rochester.edu; matthew_carter@urmc.rochester.edu;
   Igor_Gosev@URMC.rochester.edu; Derek_Bell@urmc.rochester.edu
OI Carter, Matthew Mason/0009-0001-3533-0195; Tomtschik,
   Julia/0000-0001-6982-7856
CR Aburjania N, 2021, ANN CARDIOTHORAC SUR, V10, P233, DOI 10.21037/acs-2020-cfmcs-26
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   Tong MZ, 2015, ANN THORAC SURG, V100, P1292, DOI 10.1016/j.athoracsur.2015.04.047
NR 15
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2023
VL 90
IS 6S
SU 5
BP S552
EP S555
DI 10.1097/SAP.0000000000003408
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA L3MZ9
UT WOS:001022348000021
PM 36729072
DA 2026-07-24
ER
PT J
AU Tran, R
   Haffner, ZK
   Slamin, RP
   Akbari, CM
   Evans, KK
AF Tran, Ryu
   Haffner, Zoe K.
   Slamin, Robert P.
   Akbari, Cameron M.
   Evans, Karen K.
TI Arterialized Vein Bypass Graft Recipient Vessel in Free Tissue Transfer
   Covering Diabetic Foot Ulcers Complicated by Critical Limb Ischemia
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT 38th Annual Meeting of the Northeastern-Society-of-Plastic-Surgeons
   (NESPS)
CY SEP 30-OCT 02, 2022
CL Boston, MA
DE limb salvage; lower extremity; plastic surgery; reconstruction; vein
   bypass graft; free tissue transfer; critical limb ischemia; diabetes
   mellitus; infection; antibiotic spacer; negative pressure wound therapy;
   skin graft; osteomyelitis; nonhealing wound; debridement; saphenous vein
   graft
ID IN-SITU; AMPUTATION; SALVAGE; FLOW
AB Limb salvage options are limited in diabetic patients with critical limb ischemia. Soft tissue coverage remains technically demanding with limited recipient vessels for free tissue transfer. These factors make revascularization alone challenging. When open bypass revascularization is possible, venous bypass graft is optimal and functions as a recipient vessel for staged free tissue transfer.The authors present 2 cases using a combination approach of staged venous bypass graft revascularization followed by free tissue transfer with anastomosis to the venous bypass graft resulting in successful limb preservation.Free tissue transfer to a native vessel has limited application in severe peripheral vascular disease patients because early vascular compromise threatens flap survival. In both presented cases, venous bypass graft alone was insufficient to treat their nonhealing wounds, and preoperative angiogram revealed dismal options for free tissue transfer reconstruction. However, previous venous bypass graft provided an operable vessel for free tissue transfer anastomosis. The combination of venous bypass graft and free tissue transfer proved to be ideal for successful limb preservation by providing vascularized tissue to previously ischemic angiosomes, ensuring optimal wound healing capacity. Venous bypass graft is advantageous to native arterial grafts, and its combination with free tissue transfer likely increases graft patency and flap survival. We demonstrate that end-to-side anastomosis to a venous bypass graft is a viable option in these highly comorbid patients with favorable flap outcomes.
C1 [Tran, Ryu] Georgetown Univ, Sch Med, Washington, DC USA.
   [Haffner, Zoe K.; Slamin, Robert P.; Evans, Karen K.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, Washington, DC USA.
   [Akbari, Cameron M.] MedStar Georgetown Univ Hosp, Dept Vasc Surg, Washington, DC USA.
   [Tran, Ryu] 5332 Knole Ct Apt 242, Alexandria, VA 22311 USA.
C3 Georgetown University; Georgetown University; Georgetown University
RP Tran, R (通讯作者)，5332 Knole Ct Apt 242, Alexandria, VA 22311 USA.
EM rt729@georgetown.edu; zkh@georgetown.edu; robert.p.slamin@medstar.net;
   Cameron.akbari@medstar.net; prsgeorgetownresearch@gmail.com
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   Endara M, 2013, ADV WOUND CARE, V2, P63, DOI 10.1089/wound.2011.0309
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   Lorenzetti F, 2001, EUR J VASC ENDOVASC, V22, P161, DOI 10.1053/ejvs.2001.1419
   Moran SL, 2002, PLAST RECONSTR SURG, V109, P999, DOI 10.1097/00006534-200203000-00031
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NR 15
TC 1
Z9 1
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2023
VL 90
IS 6S
SU 5
BP S570
EP S573
DI 10.1097/SAP.0000000000003406
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA L3MZ9
UT WOS:001022348000024
PM 37399481
DA 2026-07-24
ER
PT J
AU AbdelDayem, AM
   Nashed, GA
   Balamoun, HA
   Mostafa, MS
AF AbdelDayem, Albraa Mohamed
   Nashed, George Abdelfady
   Balamoun, Hany Armia
   Mostafa, Mohamed Saber
TI Effectiveness of 3-Day Prophylactic Negative Pressure Wound Therapy on
   Closed Abdominal Incisions in the Prevention of Wound Complications: A
   Randomized Controlled Trial
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article
DE Surgical site infection; Prophylactic negative pressure wound therapy;
   Seroma; Hematoma; Delayed healing; Wound dehiscence
ID SURGICAL SITE INFECTION; HIGH-RISK PATIENTS; LAPAROTOMY; SURGERY;
   PHASE-3; IMPACT
AB ObjectiveTo determine the impact of negative pressure wound therapy of closed abdominal incisions on wound complications.BackgroundSurgical wound complications including surgical site infection complicating open abdominal operations are a burden on the economy. The outcomes of SSI include prolonged hospital stays, adjuvant treatment delay, and incisional hernias leading to a decrease in the quality of life. Prophylactic negative pressure wound therapy has recently been tried with promising results.MethodsA randomized controlled trial involving 140 patients post-laparotomy with primary wound closure was divided into 2 groups (70 patients each). For the first group, NPWT dressings were applied for the first 3 days and then conventional dressings for 4 days after. For the second group, conventional dressings were applied for 7 days. Patients were followed up for SSI, seroma, wound dehiscence, and hospital stay.ResultspNPWT was associated with a significantly lower rate of SSI development compared with gauze dressings (3/70 vs. 17/70) (p = 0.001). It also had a significant effect on lowering the incidence of seroma (0/70 vs. 7/70) (p = 0.007) and delayed wound healing (0/70 vs. 8/70) (p = 0.006) and on decreasing days of hospital stay (2.2 & PLUSMN; 0.6 vs. 3.5 & PLUSMN; 1.8) (p <0.00001). No significant difference was observed with regard to hematoma (0/70 vs. 1/70) (p = 0.5) or wound dehiscence (0/70 vs. 2/70) (p = 0.5). No burst abdomens or NPWT complications were recorded in our study.ConclusionThree-day NPWT applied to primarily closed incisions is effective in reducing the incidence of SSI, seroma, and delayed wound healing in abdominal operations compared to conventional gauze dressings.
C1 [AbdelDayem, Albraa Mohamed; Nashed, George Abdelfady; Balamoun, Hany Armia; Mostafa, Mohamed Saber] Cairo Univ, Fac Med, Dept Gen Surg, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University
RP AbdelDayem, AM (通讯作者)，Cairo Univ, Fac Med, Dept Gen Surg, Cairo, Egypt.
EM a.m.dayem93@gmail.com; george.ayad@kasralainy.edu.eg;
   hanyarmiabalamoun@kasralainy.edu.eg; d.mohamedsaber@yahoo.com
RI ; AbdelDayem, Albraa/HKO-3923-2023
OI AbdelDayem, Albraa/0000-0001-7370-6336; Mostafa Saber,
   Mohamed/0000-0003-0485-3900; 
CR Andrianello S, 2021, SURGERY, V169, P1069, DOI 10.1016/j.surg.2020.10.029
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   Blackham AU, 2013, AM J SURG, V205, P647, DOI 10.1016/j.amjsurg.2012.06.007
   Boland PA, 2021, IRISH J MED SCI, V190, P261, DOI 10.1007/s11845-020-02283-7
   Borejsza-Wysocki M, 2021, VIDEOSURGERY MINIINV, V16, P686, DOI 10.5114/wiitm.2021.106426
   Brennfleck FW, 2020, TRIALS, V21, DOI 10.1186/s13063-020-04831-z
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   Kuncewitch MP, 2019, AM SURGEON, V85, P1
   Lakhani A, 2022, SURGERY, V172, P949, DOI 10.1016/j.surg.2022.05.020
   Leitao MM Jr, 2020, GYNECOL ONCOL, V159, P53, DOI 10.1016/j.ygyno.2020.06.111
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   Norman G, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub7
   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
   Shen P, 2017, J AM COLL SURGEONS, V224, P726, DOI 10.1016/j.jamcollsurg.2016.12.028
   Wick EC, 2009, DIS COLON RECTUM, V52, P374, DOI 10.1007/DCR.0b013e31819a5e45
   Wierdak M, 2021, TECH COLOPROCTOL, V25, P185, DOI 10.1007/s10151-020-02372-w
   Zaidi A, 2017, COLORECTAL DIS, V19, P283, DOI 10.1111/codi.13458
NR 28
TC 5
Z9 6
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD AUG
PY 2023
VL 27
IS 8
BP 1702
EP 1709
DI 10.1007/s11605-023-05752-3
EA JAN 2024
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA O3YU9
UT WOS:001023694800007
PM 37407900
OA hybrid
DA 2026-07-24
ER
PT J
AU Tao, ZH
   Xu, JG
   Dai, HY
   Wu, ML
   Liu, L
   Sun, J
   Xue, CY
   Wang, YC
AF Tao, Zihan
   Xu, Jianguo
   Dai, Haiying
   Wu, Minliang
   Liu, Lei
   Sun, Jie
   Xue, Chunyu
   Wang, Yuchong
TI The Application of Double-Layer-Vacuum-Assisted Closure Therapy With
   Flap Repair of Soft Tissue Defects Near the Eyes or EarDL-VAC Therapy
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Eye; ear; soft tissue defects; vacuum-assisted closure; wound repair
AB Objective:We aimed to introduce and evaluate the safety of double-layer-vacuum-assisted closure (DL-VAC) therapy with flap repair of the wound near the eyes or ears. Methods:This study is case reports of 2 patients who underwent DL-VAC therapy for tissue defects near the eyes or ears. The detailed process of the DL-VAC therapy is carefully described in this study. The postoperative wound healing process was closely observed. The biggest concern was the treatment outcome of DL-VAC therapy on the eyes and ears. Results:Two patients underwent DL-VAC therapy due to their soft tissue defects close to the eyes or ears. Both patients achieved primary wound healing and the flaps survived during the follow-up period, which ranged from 1 to 24 months. Patients did not receive any dressing change until the VAC device was removed on the 5th to 7th postoperative day. No severe complications appeared and the patients were satisfied with both appearance and function. Conclusions:Double-layer-vacuum-assisted closure therapy is an effective and safe option for the treatment of wounds near the eyes and ears.
C1 [Tao, Zihan; Xu, Jianguo; Dai, Haiying; Wu, Minliang; Liu, Lei; Sun, Jie; Xue, Chunyu; Wang, Yuchong] Naval Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai, Peoples R China.
   [Xue, Chunyu; Wang, Yuchong] Naval Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Xue, CY; Wang, YC (通讯作者)，Naval Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM 2532663961@qq.com; chxdejia@sohu.com; dhy039@163.com; wml9398@163.com;
   847081487@qq.com; 1169323265@qq.com; xcyfun@sina.com; drwangyc@163.com
RI Xu, Jian-Guo/JZD-9552-2024; Wu, Minliang/GPT-4264-2022
OI Xu, Jian-Guo/0000-0003-2514-5057; 
FU Shanghai Municipal Commission of Health and Family Planning Clinical
   Research Program [20184Y0113]; National Natural Science Foundation of
   China [81871578]
FX This study was supported by the Shanghai Municipal Commission of Health
   and Family Planning Clinical Research Program (20184Y0113), and the
   National Natural Science Foundation of China (Grant No. 81871578).
CR Anaya DA, 2007, CLIN INFECT DIS, V44, P705, DOI 10.1086/511638
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NR 19
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD JUL-AUG
PY 2023
VL 34
IS 5
BP 1476
EP 1478
DI 10.1097/SCS.0000000000009222
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA L6AP1
UT WOS:001024074200075
PM 36843113
DA 2026-07-24
ER
PT J
AU Wang, JS
   Liu, QZ
   He, D
   Xia, HL
AF Wang, Jingshuang
   Liu, Qizan
   He, Da
   Xia, Hongle
TI EFFECT OF NEGATIVE PRESSURE SEALING AND DRAINAGE (VSD) TECHNIQUE ON
   WOUND INFECTION IN ADULT ORTHOPAEDICS AND ITS INFLUENCE FITNESS
   INDICATOR
SO REVISTA INTERNACIONAL DE MEDICINA Y CIENCIAS DE LA ACTIVIDAD FISICA Y
   DEL DEPORTE
LA English
DT Article
DE Negative pressure sealing and drainage; Adult orthopedic wound
   infection; Inflammatory state; Bacterial negative rate; Wound recovery
ID OPEN FRACTURES; IIIC INJURIES; MANAGEMENT; METAANALYSIS; RISK
AB Objective: To investigate the effect of vacuum sealing drainage (VSD) in the healing of adult orthopedic wound infection, and to explore the effect of intervention on white blood cell (WBC) and C-reactive protein (CRP) levels; Methods: 80 adult Athlete patients with orthopedic wound infection who were healed in our hospital from January 2020 to January 2022 were retrospectively opted as the research subjects, and were divided into the VSD cluster (n=40, receiving VSD technology) and the control cluster according to their healing methods (CG, n=40, receiving conventional gauze dressing healing), the variations in WBC and CRP between the two clusters before healing, on the 5th day of healing, on the 10th day of healing, and on the 15th day of healing were contrasted between the two clusters, and the wound surfaces of the two clusters of athlete patients were contrasted at the above time points. The variation in appearance, the variation in the bacterial negative rate of the wound surface after the intervention was contrasted, and the wounded limb marks of the two clusters of athlete patients were followed up; Results: (1) On the 5th day, 10th day and 15th day of healing, the WBC and CRP levels in the VSD cluster were notably lower than those within the control cluster (P < 0.05); (2) On the 5th day, 10th day and 15th day of healing, the wound appearance marks in the VSD cluster were notably upper than those within the control cluster, and the variation between the clusters was notable (P < 0.05); (3) The wound bacterial conversion rates within the study cluster were 40.00%, 70.00% and 95.00% at 1 month, 2 months and 3 months after operation, respectively, which were notably upper than 17.50%, 47.50% and 80.00% within the control cluster, and the variation between the clusters was notable (P < 0.05); (4) At 1 month, 2 months and 3 months after operation, the Puno limb marks within the study cluster were notably upper than those within the control cluster, and the variation between the clusters was notable (P < 0.05); Conclusion: VSD technology has a good effect on the healing of adult orthopedic wound infection, can notably enhance the athlete patient's inflammatory state, notably enhance the bacterial negative rate of the patient's wound, help to speed up the patient's recovery process, and has positive sense for the athlete patient's wound recovery.
C1 [Wang, Jingshuang; Liu, Qizan; He, Da; Xia, Hongle] Cangzhou Hosp Integrated TCM WM Hebei, Cangzhou 061000, Hebei, Peoples R China.
RP Wang, JS (通讯作者)，Cangzhou Hosp Integrated TCM WM Hebei, Cangzhou 061000, Hebei, Peoples R China.
EM jingshuang1979@163.com
CR Ataya GE, 2019, Jornal Brasileiro de Patologia e Medicina Laboratorial, V55, DOI 10.5935/1676-2444.20190013
   Duan HJ, 2020, J WOUND CARE, V29, P510, DOI 10.12968/jowc.2020.29.9.510
   Foote CJ, 2021, J BONE JOINT SURG AM, V103, P265, DOI 10.2106/JBJS.20.01103
   Garner MR, 2020, J AM ACAD ORTHOP SUR, V28, P309, DOI 10.5435/JAAOS-D-18-00193
   Hand TL, 2020, J BONE JOINT SURG AM, V102, P1468, DOI 10.2106/JBJS.19.01358
   Higgin R, 2021, INJURY, V52, P2434, DOI 10.1016/j.injury.2021.05.042
   Horton SA, 2021, INJURY, V52, P1351, DOI 10.1016/j.injury.2021.03.057
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   Li JM, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016481
   Lin CA, 2021, J BONE JOINT SURG AM, V103, P609, DOI 10.2106/JBJS.20.01229
   Mahajan A, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph181910228
   McMahon HA, 2021, CLIN PLAST SURG, V48, P267, DOI 10.1016/j.cps.2020.12.006
   Mener A, 2021, J SURG RES, V268, P33, DOI 10.1016/j.jss.2021.05.048
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NR 21
TC 0
Z9 0
U1 0
U2 4
PU RED IRIS
PI MADRID
PA EDIF BRONCE, PLAZA DE MANUEL GOMEZ MORENO, S-N 2A PLANTA, MADRID, 28020,
   SPAIN
SN 1577-0354
J9 REV INT MED CIENC AC
JI Rev. Int. Med. Cienc. Act. Fis. Dep.
PD JUN
PY 2023
VL 23
IS 90
BP 170
EP 180
DI 10.15366/rimcafd2023.90.013
PG 11
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA L6FW9
UT WOS:001024212300003
DA 2026-07-24
ER
PT J
AU Stüben, BO
   Plitzko, GA
   Sauerbeck, J
   Busch, P
   Melling, N
   Reeh, M
   Izbicki, JR
   Rösch, T
   Bachmann, K
   Tachezy, M
AF Stueben, Bjoern-Ole
   Plitzko, Gabriel A.
   Sauerbeck, Julia
   Busch, Philipp
   Melling, Nathaniel
   Reeh, Matthias
   Izbicki, Jakob R.
   Roesch, Thomas
   Bachmann, Kai
   Tachezy, Michael
TI Minimally invasive intrathoracic negative-pressure therapy and flexible
   thoracoscopy (FlexVATS) for patients with pleural empyema
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; THORACIC-SURGERY; MANAGEMENT; DECORTICATION;
   INSTILLATION
AB To determine whether a new surgical method using a flexible endoscope (FlexVATS) to perform sparing debridement and apply negative-pressure therapy without extensive decortication may be an alternative treatment option for empyema. Surgical treatment of pleural empyema is associated with considerable postoperative complications and mortality rates, and alternative treatment options are being explored to improve patient outcomes. This was a prospective case series. Seventeen consecutive patients treated with FlexVATS between February 2021 and August 2022 were included in the study. Only patients for whom FlexVATS was the first therapeutic intervention for pleural empyema were included. Treatment success, defined as infection resolution, was the primary endpoint of the study. The secondary endpoints were length of hospital stay, 90-day mortality, and empyema cavity volume reduction. Patients who had previously been treated for pleural empyema by either drainage or surgery were excluded. The trial was performed as a single-centre study at a tertiary medical centre in Germany. In total, 17 patients with pleural empyema were included in the study. The median (IQR) duration of vacuum treatment was 15 days (8-35 days). Twelve of the 17 (71%) patients were successfully treated, and a significant reduction in the empyema cavity volume was observed. 41% of the dressing changes were performed outside the operating room. Compared with a historic cohort of conventionally treated patients (decortication via VATS or thoracotomy), the 90-day mortality rates tended to be lower without reaching statistical significance. Three patients (18%) died in hospital during treatment. No negative pressure-therapy-related complications were observed. FlexVATS therapy is a promising alternative therapy for both healthy and debilitated patients with pleural empyema. Larger randomised trials are required to validate this treatment option.
C1 [Stueben, Bjoern-Ole; Plitzko, Gabriel A.; Busch, Philipp; Melling, Nathaniel; Reeh, Matthias; Izbicki, Jakob R.; Bachmann, Kai; Tachezy, Michael] Univ Med Ctr Hamburg Eppendorf, Dept Gen Visceral & Thorac Surg, Martinistr 52, D-20246 Hamburg, Germany.
   [Sauerbeck, Julia] Univ Med Ctr Hamburg Eppendorf, Dept Diagnost & Intervent Radiol & Nucl Med, Martinistr 52, D-20246 Hamburg, Germany.
   [Roesch, Thomas] Univ Med Ctr Hamburg Eppendorf, Dept Interdisciplinary Endoscopy, Martinistr 52, D-20246 Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf
RP Stüben, BO (通讯作者)，Univ Med Ctr Hamburg Eppendorf, Dept Gen Visceral & Thorac Surg, Martinistr 52, D-20246 Hamburg, Germany.
EM stuebenb@me.com
RI /AAN-6043-2021; Tachezy, Michael/AAD-6759-2022; Reeh,
   Matthias/AAB-6917-2022
OI Plitzko, Gabriel/0009-0009-9239-2411; Stüben,
   Björn-Ole/0000-0001-8245-4548; Reeh, Matthias/0000-0001-9111-3905
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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   Ried M, 2015, Zentralbl Chir, V140 Suppl 1, pS22, DOI [10.1055/s-0035-1557771, 10.1055/s-0035-1557771]
   Shen KR, 2017, J THORAC CARDIOV SUR, V153, pE129, DOI 10.1016/j.jtcvs.2017.01.030
   Sogaard M, 2014, CHEST, V145, P189, DOI 10.1378/chest.13-1912
   Sokouti M, 2019, ARCH MED SCI, V15, P912, DOI 10.5114/aoms.2018.77723
   Stuben B., 2022, IN PRESS
   Sziklavari Z, 2016, J CARDIOTHORAC SURG, V11, DOI 10.1186/s13019-016-0543-7
   Sziklavari Z, 2015, EUR J CARDIO-THORAC, V48, pE9, DOI 10.1093/ejcts/ezv186
   Sziklavari Z, 2013, INTERACT CARDIOV TH, V17, P49, DOI 10.1093/icvts/ivt093
   Towe CW, 2021, ANN THORAC SURG, V111, P206, DOI 10.1016/j.athoracsur.2020.06.056
NR 27
TC 2
Z9 2
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 5
PY 2023
VL 13
IS 1
AR 10869
DI 10.1038/s41598-023-37961-w
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA L6UU6
UT WOS:001024600400018
PM 37407677
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhu, Y
   Dai, LY
   Luo, BJ
   Zhang, L
AF Zhu, Yi
   Dai, Lingyan
   Luo, Binjie
   Zhang, Lin
TI Meta-analysis of prophylactic negative pressure wound therapy for
   surgical site infections (SSI) in caesarean section surgery
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Article
DE negative pressure wound therapy; surgical site infections; caesarean
   section; surgical dressings
ID RISK-FACTORS; OBESE WOMEN; COMPLICATIONS; DELIVERY; TRIAL
AB Introduction: Negative pressure wound therapy (NPWT) has been used in reducing the incidence of surgical site infections (SSIs) and wound complications across various surgical categories. SSIs are a common post-surgical com-plication following caesarean section (CS) births, making it necessary to use prophylactic interventions to reduce SSI and wound complication incidences.Aim: To conduct an updated meta-analysis on randomized controlled trials (RCTs) comparing SSI incidence and wound complications in women undergoing C-sections receiving NPWT or standard dressings after wound closure.Material and methods: A systematic literature review was conducted using MEDLINE and CENTRAL databases, and clinical trial registries for RCTs that involved NPWT versus standard dressings in participants undergoing C-section procedures. The primary outcome was surgical site infection (SSI) and other wound complications (haematoma, dehiscence, seroma.Results: A total of 11 RCTs were included in the meta-analysis with information from 5,693 patients. A reduction in overall SSI incidence (RR = 0.79, 95% CI: 0.66-0.95, p = 0.01, I2 = 0%) and wound complication rate (RR = 0.86, 0.75 to 0.98, p = 0.02, I2 = 5%) was found with all studies pooled together. Subgroup analyses showed that NPWT did not significantly reduce SSI incidence when stratified by the type of C-section (emergency/elective) whereas the type of NPWT device had a differential effect on SSI reduction, with PICO NPWT systems showing a beneficial effect (RR = 0.72, 0.58 to 0.91, p = 0.006, I2 = 0%) in comparison to the PREVENA closed-incision device (RR = 0.94, 0.68 to 1.29, p = 0.73, I2 = 0%).Conclusions: Prophylactic NPWT is useful in reducing the incidence of SSIs in women undergoing C-sections based on synthesis of results from RCTs in obese women (BMI > 30 kg/m2).
C1 [Zhu, Yi; Luo, Binjie] Nanjing Med Univ, Taizhou Sch Clin Med, Dept Burn Plast Surg, Taizhou City, Jiangsu, Peoples R China.
   [Dai, Lingyan] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Ambulatory Surg Ctr, Wuhan, Hubei, Peoples R China.
   [Zhang, Lin] First Peoples Hosp Jiangxia Dist, Dept Emergency, Wuhan 430200, Hubei, Peoples R China.
   [Zhang, Lin] First Peoples Hosp Jiangxia Dist, Dept Emergency, Wuhan 430200, Hubei, Peoples R China.
C3 Nanjing Medical University; Huazhong University of Science & Technology
RP Zhang, L (通讯作者)，First Peoples Hosp Jiangxia Dist, Dept Emergency, Wuhan 430200, Hubei, Peoples R China.
EM zhanglin190209@sina.com
CR Adane F, 2019, PATIENT SAF SURG, V13, DOI 10.1186/s13037-019-0212-6
   [Anonymous], 2010, MONITORING HLTH SDGS
   Arora A, 2018, Journal of Patient Safety and Infection Control, V6, P1, DOI [10.4103/jpsic.jpsic2917, DOI 10.4103/JPSIC.JPSIC2917, 10.4103/jpsic.jpsic_29_17, DOI 10.4103/JPSIC.JPSIC_29_17]
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   Pleger SP, 2018, INT WOUND J, V15, P75, DOI 10.1111/iwj.12836
   Ruhstaller K, 2017, AM J PERINAT, V34, P1125, DOI 10.1055/s-0037-1604161
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   Sarsam SE, 2005, OBSTET GYNECOL SURV, V60, P462, DOI 10.1097/01.ogx.0000166603.43959.aa
   Shi LH, 2022, VIDEOSURGERY MINIINV, V17, P261, DOI 10.5114/wiitm.2021.112479
   Stitely M, CLIN GOV
   Tuuli MG, 2020, JAMA-J AM MED ASSOC, V324, P1180, DOI 10.1001/jama.2020.13361
   Tuuli MG, 2017, AM J OBSTET GYNECOL, V216, pS245, DOI 10.1016/j.ajog.2016.11.670
   Wihbey KA, 2018, OBSTET GYNECOL, V132, P377, DOI [10.1097/AOG.0000000000002744, 10.1097/aog.0000000000002744]
   Yu LL, 2018, AM J OBSTET GYNECOL, V218, P200, DOI 10.1016/j.ajog.2017.09.017
NR 34
TC 5
Z9 5
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2023
VL 18
IS 2
BP 224
EP 234
DI 10.5114/wiitm.2023.125913
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA L7HI5
UT WOS:001024928700004
PM 37680737
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Taylor, D
   Dooreemeah, D
   Al-Habbal, Y
   Jacobs, R
AF Taylor, Danielle
   Dooreemeah, Dilshad
   Al-Habbal, Yahya
   Jacobs, Rodney
TI Vacuum assisted closure with mesh mediated fascial traction of open
   abdominal wounds and acute fascial dehiscence, a single institution
   experience
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE burst abdomen; hernia surgery; open abdomen
ID OPEN ABDOMEN; VENTRAL HERNIA; TOXIN; MANAGEMENT; INJECTION
AB Backgrounds: Laparostomy is a common means of managing surgical catastrophes, but often results in large ventral hernias which prove difficult to repair. It is also associated with high rates of enteric fistula formation. Dynamic methods of managing the open abdomen have been shown to result in higher rates of fascial closure and fewer complications. Recent publications have suggested the addition of chemical components relaxation with botulinum toxin has an added advantage over prior methods.Methods: We report on a series of emergent cases managed by the combination of Botulinum toxin A (BTA) mediated chemical relaxation with a modified method of mesh-mediated fascial traction (MMFT) and negative pressure wound therapy (NPWT).Results: Thirteen cases (nine laparostomies and four fascial dehiscence) were successfully closed in a median of 12 days, using a median of 4 'tightenings', with no clinical herniation detected at follow up so far (median 183 days, IQR 123-292). There were no procedure-related complications, but one death from the underling pathology.Conclusions: We report further cases of vacuum assisted mesh-mediated fascial traction (VA-MMFT) utilizing BTA in successfully managing laparostomy and abdominal wound dehiscence and continues the known high rate of successful fascial closure seen when applied in treating the open abdomen.
C1 [Taylor, Danielle; Dooreemeah, Dilshad; Al-Habbal, Yahya; Jacobs, Rodney] Western Hlth, Dept Surg, Melbourne, Vic, Australia.
   [Taylor, Danielle] Western Hlth, Dept Surg, 160 Gordon St, Footscray, VIC 3011, Australia.
C3 Western Health
RP Taylor, D (通讯作者)，Western Hlth, Dept Surg, 160 Gordon St, Footscray, VIC 3011, Australia.
EM drdanielleltaylor@gmail.com
OI jacobs, rodney/0000-0002-8757-7122; Taylor,
   Danielle/0000-0001-6035-639X; Dooreemeah, Dilshad/0000-0001-7883-5938
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Berrevoet F, 2021, FRONT SURG, V7, DOI 10.3389/fsurg.2020.606539
   Bjorsum-Meyer T, 2013, DAN MED J, V60
   Burlew CC, 2012, J TRAUMA ACUTE CARE, V72, P235, DOI 10.1097/TA.0b013e318236b319
   Çakmak M, 2006, J PEDIATR SURG, V41, P821, DOI 10.1016/j.jpedsurg.2005.12.023
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   Dennis A, 2013, J TRAUMA ACUTE CARE, V74, P1486, DOI 10.1097/TA.0b013e3182924950
   Denys A, 2021, HERNIA, V25, P449, DOI 10.1007/s10029-020-02294-4
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   Jardim Y., 2018, J ABDOM WALL RECONST, V1, P1002
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   Petersson P, 2020, FRONT SURG, V7, DOI 10.3389/fsurg.2020.577104
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NR 26
TC 0
Z9 0
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD JUL
PY 2023
VL 93
IS 7-8
BP 1793
EP 1798
DI 10.1111/ans.18592
EA JUL 2023
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA W7QQ5
UT WOS:001026973400001
PM 37432870
OA Bronze
DA 2026-07-24
ER
PT J
AU Shi, XF
   Lin, LX
   Sun, JY
AF Shi, Xiufang
   Lin, Lixin
   Sun, Jianying
TI The Value of Continuous Closed Negative Pressure Drainage Combined with
   Antibacterial Biofilm Dressing in Postoperative Wound Healing for Severe
   Pancreatitis
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
AB Objective To investigate the application value of continuous vacuum sealing drainage (VSD) combined with antibacterial biofilm hydraulic fiber dressing in wound healing after surgery for severe acute pancreatitis (SAP).
   Methods A total of 82 SAP patients who underwent minimally invasive surgery in our hospital from March 2021 to September 2022 were randomly divided into two groups using a random number table method. Each group consisted of 41 cases. Both groups received surgical treatment, with the control group receiving VSD treatment and the observation group receiving VSD treatment combined with antibacterial biofilm hydraulic fiber dressing. The postoperative recovery efficiency, preoperative and postoperative wound area reduction rate, pressure ulcer healing score (PUSH), serum biological indicators (white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT)), and the rate of wound-related adverse reactions were compared between the two groups.
   Results There was no statistical difference between the two groups in the time to resume eating (P >.05). However, the wound healing time and hospitalization days in the observation group were significantly shorter than those in the control group (P <.05). After 7 and 14 days of treatment, the wound area reduction rate in the observation group was significantly higher than in the control group, and the PUSH score was significantly lower than in the control group (P <.05). WBC, CRP, and PCT levels in the observation group were lower than in the control group (P <.05). The incidence of wound-related adverse reactions in the observation group (12.20%) was significantly lower than that in the control group (34.15%) (P <.05).
   Conclusions The application of VSD combined with antibacterial biofilm hydraulic fiber dressing in the postoperative wound healing of SAP has a significant effect. It improves wound healing efficiency, reduces pressure ulcer scores, decreases inflammation indicators, and lowers the incidence of adverse reactions. While further research is needed to determine its impact on infection and inflammation prevention, this treatment approach shows promise for clinical application.
C1 [Shi, Xiufang; Lin, Lixin; Sun, Jianying] Yantai Yuhuangding Hosp, Yantai, Peoples R China.
RP Sun, JY (通讯作者)，Yantai Yuhuangding Hosp, Yantai, Peoples R China.
EM jianying_sun10@163.com
CR Chinese Pancreatic Surgery Association Chinese Society of Surgery Chinese Medical Association, 2021, Zhonghua Wai Ke Za Zhi, V59, P578, DOI 10.3760/cma.j.cn112139-20210416-00172
   Esendagli G, 2018, J SURG RES, V223, P188, DOI 10.1016/j.jss.2017.11.030
   Garg PK, 2019, GASTROENTEROLOGY, V156, P2008, DOI 10.1053/j.gastro.2018.12.041
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   Hon J, 2010, OSTOMY WOUND MANAG, V56, P26
   Hu JJ, 2022, ADV HEALTHC MATER, V11, DOI 10.1002/adhm.202200299
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   Loske G, 2018, ENDOSC INT OPEN, V6, pE865, DOI 10.1055/a-0599-5886
   Metcalf DG, 2017, INT WOUND J, V14, P203, DOI 10.1111/iwj.12590
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   Petrov MS, 2019, NAT REV GASTRO HEPAT, V16, P175, DOI 10.1038/s41575-018-0087-5
   Tavakolian M, 2020, ACS APPL MATER INTER, V12, P39991, DOI 10.1021/acsami.0c08784
   Yu J A, 2019, Zhonghua Shao Shang Za Zhi, V35, P842, DOI 10.3760/cma.j.issn.1009-2587.2019.12.003
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   Zmejkoski DZ, 2021, INT J BIOL MACROMOL, V191, P315, DOI 10.1016/j.ijbiomac.2021.09.118
NR 15
TC 8
Z9 8
U1 0
U2 5
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD JUL-AUG
PY 2023
VL 29
IS 5
BP 375
EP 379
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA M2TQ1
UT WOS:001028759700057
PM 37235500
DA 2026-07-24
ER
PT J
AU Santos, J
   Delaplain, PT
   Barie, PS
   Dvorak, J
   Mele, TS
   Gelbard, R
   Guidry, CA
   Schubl, SD
   Surgical Infect Soc
AF Santos, Jeffrey T.
   Delaplain, Patrick S.
   Barie, Philip
   Dvorak, Justin S.
   Mele, Tina
   Gelbard, Rondi A.
   Guidry, Christopher D.
   Schubl, Sebastian
   Surgical Infection Society
TI Different Surgeon, Different Closure: Lack of Consensus on Appropriate
   Closure Technique for Various Case Scenarios
SO SURGICAL INFECTIONS
LA English
DT Article
DE hospital-acquired infection; incision closure; incision management;
   surgical decision making; surgical site infection
ID SURGICAL SITE INFECTION; WOUND CLASSIFICATION DISCREPANCIES;
   CARE-ASSOCIATED INFECTIONS; ANTIMICROBIAL PROPHYLAXIS; POSTOPERATIVE
   INFECTION; PREVENTION; SURVEILLANCE; RISK; RATES; US
AB Background: Many techniques for closure of surgical incisions are available to the surgeon, but there is minimal guidance regarding which technique(s) should be utilized at the conclusion of surgery and under what circumstances.Hypothesis: Management of incisions at the conclusion of surgery lacks consensus and varies among individual surgeons.Methods: The Surgical Infection Society membership was surveyed on the management of incisions at the conclusion of surgery. Several case scenarios were provided to test the influences of operation type, intra-operative contamination, and hemodynamic stability on incision management (e.g., close fascia or skin, use of incision/wound vacuum-assisted closure [VAC] device). Responses by two-thirds of participants were required to achieve consensus. Data analysis by & chi;(2) test and logistic regression, a = 0.05. Response heterogeneity was quantified by the Shannon index (SI).Results: Among 78 respondents, consensus was achieved for elective splenectomy (91% close skin/dry dressing). Open appendectomy and left colectomy/end-colostomy had the greatest heterogeneity (SI, 1.68 and 1.63, respectively). During trauma laparotomy, the majority used damage control for hemodynamic instability (53%-67%) but not for hemodynamically stable patients (0%-1.3%; p < 0.001). Additional consensus was achieved for close skin/dry dressing for hemodynamically stable trauma splenectomy patients (87%) and fascia open/wound VAC for hemodynamically unstable colon resection/anastomosis (67%). Fecal diversion for rectal injury and colon resection/anastomosis (both when hemodynamically stable) had high heterogeneity (SI, 1.56 and 1.48, respectively). In penetrating trauma, sentiment was for more use of wet-to-dry dressings and incision/wound VAC with increased contamination in hemodynamically stable patients.Conclusions: Damage control was favored in hemodynamically unstable trauma patients, with use of wet-to-dry dressings and incision/wound VAC with spillage after penetrating trauma. However, most scenarios did not achieve consensus. High variability of practices regarding incision management at the conclusion of surgery was confirmed. Prospective studies and evidence-based guidance are needed to guide decision making at end-operation.
C1 [Santos, Jeffrey T.; Schubl, Sebastian] Univ Calif Irvine, Dept Surg, 3800 Chapman Ave,Suite 6200, Orange, CA 92868 USA.
   [Delaplain, Patrick S.] Harvard Med Syst, Boston Childrens Hosp, Dept Surg, Boston, MA USA.
   [Barie, Philip] Weill Cornell Med, Dept Surg, Div Trauma Burns Acute & Crit Care, New York, NY USA.
   [Dvorak, Justin S.] Case Western Reserve Univ, MetroHlth Med Ctr, Dept Surg, Div Trauma Crit Care Burns & Acute Care Surg,Sch M, Cleveland, OH USA.
   [Mele, Tina] Univ Western Ontario, Schulich Sch Med & Dent, Dept Surg, Div Gen Surg, London, ON, Canada.
   [Mele, Tina] Univ Western Ontario, Schulich Sch Med & Dent, Dept Surg, Div Crit Care, London, ON, Canada.
   [Gelbard, Rondi A.] Univ Alabama Birmingham, Heersink Sch Med, Dept Surg, Div Trauma & Acute Care Surg, Birmingham, AL USA.
   [Guidry, Christopher D.] Univ Kansas, Med Ctr, Dept Surg, Div Acute Care Surg, Kansas City, KS USA.
C3 University of California System; University of California Irvine;
   Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Cornell University; Weill Cornell Medicine;
   MetroHealth System; University System of Ohio; Case Western Reserve
   University; Western University (University of Western Ontario); Western
   University (University of Western Ontario); University of Alabama
   System; University of Alabama Birmingham; University of Kansas;
   University of Kansas Medical Center
RP Santos, J (通讯作者)，Univ Calif Irvine, Dept Surg, 3800 Chapman Ave,Suite 6200, Orange, CA 92868 USA.
EM Jwsantos@hs.uci.edu
RI Guidry, Christopher/GRS-5109-2022
OI Mele, Tina/0000-0002-6617-9790
CR Ban KA, 2017, J AM COLL SURGEONS, V224, P59, DOI 10.1016/j.jamcollsurg.2016.10.029
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   OLSON MM, 1990, ARCH SURG-CHICAGO, V125, P794
   Onyekwelu I, 2017, JAAOS GLOB RES REV, V1, DOI 10.5435/JAAOSGlobal-D-17-00022
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   SHANNON CE, 1948, BELL SYST TECH J, V27, P379, DOI 10.1016/j.marpolbul.2010.12.009
   SHERERTZ RJ, 1992, AM J INFECT CONTROL, V20, P263
   Singh S, 2020, AM J SURG, V220, P1115, DOI 10.1016/j.amjsurg.2020.04.017
   U.S Department of Health and Human Services, 2021, NAT HAI TARG METR
   Wang-Chan A, 2017, J SURG RES, V215, P132, DOI 10.1016/j.jss.2017.03.034
   Zimlichman E, 2013, JAMA INTERN MED, V173, P2039, DOI 10.1001/jamainternmed.2013.9763
NR 31
TC 2
Z9 2
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD AUG 1
PY 2023
VL 24
IS 6
BP 541
EP 548
DI 10.1089/sur.2023.143
EA JUL 2023
PG 8
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA O0XP5
UT WOS:001030614600001
PM 37462905
DA 2026-07-24
ER
PT J
AU LiBrizzi, CL
   Sabharwal, S
   Forsberg, JA
   Leddy, L
   Doung, YC
   Morris, CD
   Levin, AS
AF LiBrizzi, Christa L. L.
   Sabharwal, Samir
   Forsberg, Jonathan A. A.
   Leddy, Lee
   Doung, Yee-Cheen
   Morris, Carol D. D.
   Levin, Adam S. S.
TI Does the Use of Negative Pressure Wound Therapy and Postoperative Drains
   Impact the Development of Surgical Site Infections? A PARITY Trial
   Secondary Analysis
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID KNEE ARTHROPLASTY; BREAST SURGERY; RISK-FACTORS; HIP
AB Background:Surgical site infections (SSIs) represent a major complication following oncologic reconstructions. Our objectives were (1) to assess whether the use of postoperative drains and/or negative pressure wound therapy (NPWT) were associated with SSIs following lower-extremity oncologic reconstruction and (2) to identify factors associated with the duration of postoperative drains and with the duration of NPWT.Methods:This is a secondary analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial, a multi-institution randomized controlled trial of lower-extremity oncologic reconstructions. Data were recorded regarding the use of drains alone, NPWT alone, or both NPWT and drains, including the total duration of each postoperatively. We analyzed postoperative drain duration and associations with tourniquet use, intraoperative thromboprophylaxis or antifibrinolytic use, incision length, resection length, and total operative time, through use of a linear regression model. A Cox proportional hazards model was used to evaluate the independent predictors of SSI.Results:Overall, 604 patients were included and the incidence of SSI was 15.9%. Postoperative drains alone were used in 409 patients (67.7%), NPWT alone was used in 15 patients (2.5%), and both postoperative drains and NPWT were used in 68 patients (11.3%). The median (and interquartile range [IQR]) duration of drains and of NPWT was 3 days (IQR, 2 to 5 days) and 6 days (IQR, 4 to 8 days), respectively. The use of postoperative drains alone, NPWT alone, or both drains and NPWT was not associated with SSI (p = 0.14). Increased postoperative drain duration was associated with longer operative times and no intraoperative tourniquet use, as shown on linear regression analysis (p < 0.001 and p = 0.03, respectively). A postoperative drain duration of & GE;14 days (hazard ratio [HR], 3.6; 95% confidence interval [CI], 1.3 to 9.6; p = 0.01) and an operative time of & GE;8 hours (HR, 4.5; 95% CI, 1.7 to 11.9; p = 0.002) were independent predictors of SSI following lower-extremity oncologic reconstruction.Conclusions:A postoperative drain duration of & GE;14 days and an operative time of & GE;8 hours were independent predictors of SSI following lower-extremity oncologic reconstruction. Neither the use of postoperative drains nor the use of NPWT was a predictor of SSI. Future research is required to delineate the association of the combined use of postoperative drains and NPWT with SSI.
C1 [LiBrizzi, Christa L. L.; Sabharwal, Samir; Forsberg, Jonathan A. A.; Levin, Adam S. S.] Johns Hopkins Univ, Dept Orthopaed Surg, Div Orthopaed Oncol, Sch Med, Baltimore, MD 21205 USA.
   [Leddy, Lee] Med Univ South Carolina, Dept Orthopaed Surg, Charleston, SC USA.
   [Doung, Yee-Cheen] Oregon Hlth & Sci Univ, Dept Orthopaed & Rehabil, Portland, OR USA.
   [Morris, Carol D. D.] Mem Sloan Kettering Canc Ctr, Div Orthopaed Surg, New York, NY USA.
C3 Johns Hopkins University; Medical University of South Carolina; Oregon
   Health & Science University; Memorial Sloan Kettering Cancer Center
RP Levin, AS (通讯作者)，Johns Hopkins Univ, Dept Orthopaed Surg, Div Orthopaed Oncol, Sch Med, Baltimore, MD 21205 USA.
EM clibriz1@jhmi.edu; ssabhar1@jhmi.edu; jforsbe1@jh.edu; leddyl@musc.edu;
   doung@ohsu.edu; morrisc@mskcc.org; alevin25@jhmi.edu
RI ; Forsberg, Jonathan/K-2116-2012; Sabharwal, Samir/AAK-2427-2020
OI LiBrizzi, Christa/0000-0003-0214-4406; Forsberg,
   Jonathan/0000-0003-3835-0615; Morris, Carol/0000-0002-4007-9476;
   Sabharwal, Samir/0000-0003-3250-6615; Levin, Adam/0000-0003-0450-7821
CR Ailaney N, 2021, J ARTHROPLASTY, V36, P2402, DOI 10.1016/j.arth.2020.11.039
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NR 26
TC 7
Z9 8
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD JUL 19
PY 2023
VL 105
IS SUPPL 1
SU 1
BP 34
EP 40
DI 10.2106/JBJS.22.01185
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA M9RR5
UT WOS:001033518500008
PM 37466578
DA 2026-07-24
ER
PT J
AU Cwalinski, J
   Hermann, J
   Banasiewicz, T
AF Cwalinski, Jaroslaw
   Hermann, Jacek
   Banasiewicz, Tomasz
TI Healing Peristomal Wounds Around Retracted Stomas with Negative-Pressure
   Wound Therapy: A Case Series
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE hydrofiber dressing; negative-pressure wound therapy; ostomy; peristomal
   infection; peristomal leak; retraction; wound care
ID COMPLICATIONS; MANAGEMENT; OSTOMY
AB One method for treating a retracted stoma is a vacuum dressing that cleans the wound and protects against intestinal leakage. This case series describes the use of an integrated, single-use negative-pressure wound therapy (NPWT) dressing to treat retracted stomas as an alternative to other noninvasive remedies. The report includes seven patients who were hospitalized in the authors' surgical department from 2019 to 2020. All patients developed severe peristomal infection that failed to respond to local treatment with proper ostomy appliances or specialist dressings. After cleaning each wound and removing necrotic lesions, the authors applied a single-use hydrofiber NPWT dressing to each patient. The dressing was changed every 2 to 5 days, depending on the effects of the therapy. The stoma orifice was covered with a bag with two-piece ostomy systems. The peristomal wound healed in all cases, and leakage was eliminated. The mean time of treatment was 14 days (range, 10-21 days), and the vacuum dressings were changed an average of four times (range, 3-7 times). None of the patients required a stoma translocation or other additional surgery. Three patients received systemic IV antibiotic therapy to treat general infection. Single-use NPWT dressings protect peristomal wounds from bowel leakage and do not hinder the application of stoma bags. This system, similar to standard NPWT devices, effectively protects infected stomas from retraction.
C1 [Cwalinski, Jaroslaw; Hermann, Jacek; Banasiewicz, Tomasz] Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Cwalinski, J (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Poznan, Poland.
RI Cwalinski, Jaroslaw/IAR-7448-2023
CR Ambe PC, 2018, DTSCH ARZTEBL INT, V115, P182, DOI 10.3238/arztebl.2018.0182
   Banasiewicz T, 2011, VIDEOSURGERY MINIINV, V6, P155, DOI 10.5114/wiitm.2011.24694
   Bass EM, 1997, DIS COLON RECTUM, V40, P440, DOI 10.1007/BF02258389
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   Cwaliński J, 2018, NEG PRESS WOUND THER, V5, P10, DOI 10.18487/npwtj.v5i4.45
   Duchesne JC, 2002, AM SURGEON, V68, P961
   Goldberg M, 2010, J WOUND OSTOMY CONT, V37, P596, DOI 10.1097/WON.0b013e3181f97e37
   Hasan MY, 2015, DIABET FOOT ANKLE, V6, DOI 10.3402/dfa.v6.27618
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   Kwiatt M, 2013, CLIN COLON RECT SURG, V26, P112, DOI 10.1055/s-0033-1348050
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   Li TT, 2016, EXP THER MED, V11, P769, DOI 10.3892/etm.2016.3008
   Malik TAM, 2018, ANN ROY COLL SURG, V100, P501, DOI 10.1308/rcsann.2018.0126
   Malmsjo Malin, 2014, Eplasty, V14, pe15
   Mohamed E., 2019, J NURS HLTH SCI, V8, P31
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   Salvadalena G, 2021, J WOUND OSTOMY CONT, V48, P533, DOI 10.1097/WON.0000000000000820
   Sheetz KH, 2014, DIS COLON RECTUM, V57, P632, DOI 10.1097/DCR.0000000000000038
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NR 26
TC 2
Z9 3
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2023
VL 36
IS 8
BP 435
EP 440
DI 10.1097/ASW.0000000000000006
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA M9VZ3
UT WOS:001033630600011
PM 37471448
DA 2026-07-24
ER
PT J
AU Chen, JH
   Li, YB
   Li, DG
   Zeng, XM
   Yao, QY
   Fu, J
   Wang, GH
   Huang, XY
AF Chen, Ju-hua
   Li, Yu-bo
   Li, De-gang
   Zeng, Xiao-mei
   Yao, Qiu-yuan
   Fu, Jun
   Wang, Gong-he
   Huang, Xiao-yan
TI Vacuum sealing drainage to treat Fournier's gangrene
SO BMC SURGERY
LA English
DT Article
DE Fournier's gangrene; Vacuum sealing drainage; Debridement; Wound
   reconstruction; Soft tissue infection; Necrosis
ID ASSISTED CLOSURE; RETROSPECTIVE ANALYSIS; THERAPY
AB BackgroundVacuum sealing drainage (VSD) is widely applied in complex wound repair. We aimed to compare traditional debridement and drainage and VSD in treating Fournier's gangrene (FG).MethodsData of patients surgically treated for FG were retrospectively analyzed.ResultsOf the 36 patients (men: 31, women: 5; mean age: 53.5 & PLUSMN; 11.3 [range: 28-74] years) included in the study, no patients died. Between-group differences regarding sex, age, BMI, time from first debridement to wound healing, number of debridements, FGSI, and shock were not statistically significant (P > 0.05). However, lesion diameter, colostomy, VAS score, dressing changes, analgesic use, length of hospital stay, and wound reconstruction method (& chi;(2) = 5.43, P = 0.04) exhibited statistically significant differences. Tension-relieving sutures (6 vs. 21) and flap transfer (4 vs. 2) were applied in Groups I and II, respectively.ConclusionVSD can reduce postoperative dressing changes and analgesic use, and shrunk the wound area, thereby reducing flap transfer in wound reconstruction.
C1 [Chen, Ju-hua] Jinggangshan Univ, Colorectal Surg Div, Affiliated Hosp, Jian 343000, Jiangxi, Peoples R China.
   [Li, Yu-bo; Li, De-gang; Yao, Qiu-yuan; Fu, Jun; Wang, Gong-he; Huang, Xiao-yan] Guangxi Univ Chinese Med, Colorectal Surg Div, Affiliated Hosp 1, Dongge Rd 89-9, Nanning 530023, Guangxi, Peoples R China.
   [Zeng, Xiao-mei] Colorectal Surg Div, Tradit Chinese Med Guiping city, Guiping 537200, Guangxi, Peoples R China.
C3 Jinggangshan University; Guangxi University of Chinese Medicine
RP Li, YB (通讯作者)，Guangxi Univ Chinese Med, Colorectal Surg Div, Affiliated Hosp 1, Dongge Rd 89-9, Nanning 530023, Guangxi, Peoples R China.
EM liyubo0323004@126.com
OI Li, Yubo/0009-0006-1016-1408
CR Boughanmi F, 2021, PAN AFR MED J, V38, DOI 10.11604/pamj.2021.38.23.25863
   Cuccia G, 2009, UROL INT, V82, P426, DOI 10.1159/000218532
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NR 19
TC 11
Z9 13
U1 1
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD JUL 26
PY 2023
VL 23
IS 1
AR 211
DI 10.1186/s12893-023-02109-0
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA N0FZ7
UT WOS:001033891800003
PM 37496026
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Vijayan, D
   Hodgkinson, JD
   Li, E
   Pinkney, T
   Slade, D
AF Vijayan, Deepak
   Hodgkinson, Jonathan D.
   Li, Elizabeth
   Pinkney, Thomas
   Slade, Dominic
TI National Open Abdomen Audit (NOAA) - protocol for an observational audit
   of the use and management of the open abdomen in secondary care across
   Great Britain and Ireland
SO COLORECTAL DISEASE
LA English
DT Article
DE damage control laparotomy; fascial closure; intestinal failure;
   intestinal fistula; negative pressure wound therapy; open abdomen;
   peritonitis
AB Aim Use of open abdomen (OA) remains an important life-saving manoeuvre in the management of trauma and the abdominal catastrophe. The National Open Abdomen Audit (NOAA) is an audit project investigating the indications, management, and subsequent outcomes of OA treatment throughout the UK. The aim is to generate a snapshot of practice which will inform the management of future patients and potentially reduce the significant harm that can be associated with OA.Methods and analysis NOAA is a collaborative, prospective observational audit recruiting patients from across Great Britain and Ireland. The study will open from July 2023 with rolling recruitment across participating sites. All adult patients who leave theatre with an OA will be included and followed-up for 90 days. The primary objective is to prospectively audit the national variability in the management of the OA. Secondary outcomes include the treatment modality used for OA, indication, outcome of treatment and complications, including mortality and development of intestinal failure. All data will be recorded and managed using the secure REDCap electronic data capture and analysed using Stata (version 16.1). Results will be reported in accordance with the STROBE statement.Conclusion Results will be used to formulate a practical clinical guideline on when to implement an OA along with a stepwise management plan once initiated to reduce the associated morbidity and mortality. It is hoped that participation in this study will facilitate education of surgeons with a "trickle down" effect on all members of the surgical team and remove variability in the management.
C1 [Vijayan, Deepak; Li, Elizabeth] Univ Birmingham, BiCOPS, Birmingham Clin Trials, Publ Hlth Bldg, Birmingham, England.
   [Hodgkinson, Jonathan D.] Oxford Univ Hosp NHS Fdn Trust, Churchill Hosp, Oxford, England.
   [Slade, Dominic] Salford Royal NHS Fdn Trust, Northern Care Alliance, Salford, England.
   [Slade, Dominic] Salford Royal NHS Fdn Trust, Stott Lane, Salford M6 8HD, England.
C3 University of Birmingham; University of Oxford; Oxford University
   Hospitals NHS Foundation Trust; Salford Royal NHS Foundation Trust;
   Salford Royal NHS Foundation Trust
RP Slade, D (通讯作者)，Salford Royal NHS Fdn Trust, Stott Lane, Salford M6 8HD, England.
EM dominic.slade@nca.nhs.uk
RI ; Slade, Dominic/AAE-8585-2022; Pinkney, Thomas/HGA-4022-2022; Li,
   Elizabeth/AFS-1376-2022
OI Li, Elizabeth/0000-0001-5961-2894; Slade, Dominic/0000-0002-6032-8580;
   Ahmed, Nauman/0000-0002-8976-3578; Pinkney, Thomas/0000-0001-7320-6673; 
FU Bowel Research UK; Birmingham Centre for Observational and Prospective
   Studies (BiCOPS); Salford Royal NHS Foundation Trust
FX This study has been funded by Bowel Research UK. The study will be
   coordinated via Birmingham Centre for Observational and Prospective
   Studies (BiCOPS) who will provide material and technological support.
   Participating centres will not bear any costs for being part of this
   audit. Similarly, no financial reimbursement will be made to units or
   investigators for their involvement. The sponsor for NOAA is the Salford
   Royal NHS Foundation Trust. Neither the funder nor the sponsor have had
   any input in the design of the study or data analysis
CR [Anonymous], National Emergency Laparotomy Audit (NELA) Project Team. Principle Standards Reported by the National Emergency Laparotomy Audit (NELA)
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   Carlson GL, 2013, ANN SURG, V257, P1154, DOI 10.1097/SLA.0b013e31828b8bc8
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NR 9
TC 0
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JUL
PY 2023
VL 25
IS 7
BP 1512
EP 1518
DI 10.1111/codi.16642
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA N0MD9
UT WOS:001034052300023
PM 37477409
DA 2026-07-24
ER
PT J
AU Madhuchandra, P
   Balaji, SM
AF Madhuchandra, P.
   Balaji, S. Muthukumar
TI A Novel Approach in the Management of Tibial Plateau Fractures with
   Compartment Syndrome
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Impending Compartment syndrome; Fasciotomy; Tibial plateau fractures
ID INVASIVE STABILIZATION SYSTEM; FIXATION
AB BackgroundCompartment syndrome in tibial plateau fractures presents a formidable challenge for treating orthopedic surgeons. The most common strategy is early fasciotomy and external fixation, followed by a second stage definitive fixation. We conducted a prospective study of tibial plateau fractures of Schatzker Type V and VI with impending compartment syndrome treated by single-stage double incision fasciotomy and dual internal fixation and Vacuum-Assisted Closure (VAC).Materials and MethodsThe study was between May 2014 and February 2019. 21 patients with impending compartment syndrome who underwent single-stage double incision fasciotomy and Open Reduction and Internal Fixation (ORIF) with dual plate were included in the study. The functional and radiological outcome was measured using the modified Rasmussen functional and radiological scoring and The Western Ontario and McMaster Universities Arthritis Index (WOMAC).ResultsThe mean age of patients was 38.7 years (Standard deviation of & PLUSMN; 9.48). The mean follow-up period was 27 months (Standard deviation of & PLUSMN; 6.51). The mean functional and radiological modified Rasmussen score was 27.28 (range 21 to 29) & 8 (range 7 to 10), respectively. 4 patients had excellent outcomes, and 17 patients had good results. The mean WOMAC score was 8.04 (Standard deviation of & PLUSMN; 5.35). Five patients had a score of 0, 14 patients had a score of 1-10 and 2 had a score of 11-20.ConclusionsThe early double incision fasciotomy and definitive internal fixation with dual plate and VAC as single-stage surgery in patients with impending compartment syndrome help to obtain excellent to good functional outcomes with reduced complications.
C1 [Madhuchandra, P.] BGS Global Inst Med Sci, Dept Orthopaed, Bengaluru, India.
   [Balaji, S. Muthukumar] SRM Inst Sci & Technol, SRM Med Coll & Res Ctr, Dept Orthopaed, Chennai, India.
   [Madhuchandra, P.] 757,5th Main Rd,ISRO Layout, Bangalore 560078, Karnataka, India.
C3 SRM Institute of Science & Technology Chennai
RP Madhuchandra, P (通讯作者)，BGS Global Inst Med Sci, Dept Orthopaed, Bengaluru, India.; Madhuchandra, P (通讯作者)，757,5th Main Rd,ISRO Layout, Bangalore 560078, Karnataka, India.
EM drmadhuchandrap@gmail.com; mkbmkb79@gmail.com
OI P, Madhuchana/0000-0001-9708-9184
CR Akbari Aghdam H, 2019, EUR J ORTHOP SURG TR, V29, P183, DOI 10.1007/s00590-018-2275-y
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NR 24
TC 2
Z9 4
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD SEP
PY 2023
VL 57
IS 9
BP 1435
EP 1442
DI 10.1007/s43465-023-00955-x
EA JUL 2023
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA P5QR7
UT WOS:001034557800001
PM 37609025
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Baek, S
   Park, JH
AF Baek, Seungchul
   Park, Jun Ho
TI Negative Pressure Wound Therapy (NPWT) after Hybrid Reconstruction of
   Occipital Pressure Sore Using Local Flap and Skin Graft
SO MEDICINA-LITHUANIA
LA English
DT Article
DE pressure sores; occipital scalp; negative pressure wound therapy; local
   flap; split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE; ACELLULAR DERMAL MATRIX; SCALP; ULCERS
AB Background and objectives: Pressure sores are a common medical burden among patients, particularly those who are bedridden or frail. Surgical management of occipital pressure sores poses unique challenges due to limited elasticity and the spherical shape of the scalp. This study aims to evaluate the efficacy and safety of a novel reconstruction method utilizing a local transpositional flap and split-thickness skin graft with negative pressure wound therapy (NPWT) for occipital pressure sore treatment. Material and methods: A retrospective analysis was performed on patients with occipital pressure sores who underwent hybrid reconstructions using a local flap and split-thickness skin graft in conjunction with NPWT. Surgical outcomes, including flap survival rate, graft take percentage, and complications, were assessed. A comparative analysis was performed between the NPWT group and the conventional dressing group. Results: The NPWT group (n = 24) demonstrated a significantly higher mean graft take percentage at postoperative day 14 compared with the conventional dressing group (n = 22) (98.2% vs. 81.2%, p < 0.05). No significant difference in flap survival rate was observed between the two groups. Conclusions: As the aging population continues to grow, occipital pressure sores have gained significant attention as a crucial medical condition. The innovative surgical method incorporating NPWT offers an efficient and safe treatment option for patients with occipital pressure sores, potentially establishing itself as the future gold standard for managing this condition.
C1 [Baek, Seungchul; Park, Jun Ho] Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Plast & Reconstruct Surg, Coll Med, Seoul 07061, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital
RP Park, JH (通讯作者)，Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Plast & Reconstruct Surg, Coll Med, Seoul 07061, South Korea.
EM jsean1@naver.com
RI Park, Jun Ho/HPH-3570-2023
OI Park, Jun Ho/0000-0003-0235-1261; BAEK, SEUNGCHUL/0000-0001-6979-0934
FU Seoul National University Hospital Research Fund [0420214050]
FX This research was supported by a clinical research grant-in-aid from
   Seoul National University Hospital Research Fund (No. 0420214050).
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NR 39
TC 6
Z9 8
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JUL
PY 2023
VL 59
IS 7
AR 1342
DI 10.3390/medicina59071342
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N4JD0
UT WOS:001036684400001
PM 37512153
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Dornseifer, U
   Pfeiler, PP
   Kargl, L
   Moog, P
   Schilling, AF
   Ninkovic, M
AF Dornseifer, Ulf
   Pfeiler, Peter Paul
   Kargl, Lukas
   Moog, Philipp
   Schilling, Arndt F.
   Ninkovic, Milomir
TI Negative Pressure Wound Therapy in Free Muscle Flaps-Risk or Benefit?
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE free flap; negative pressure wound therapy; VAC; flap edema; flap
   perfusion
ID LOWER-EXTREMITY; DANGLING PROCEDURE; RECONSTRUCTION; MOBILIZATION;
   MICROCIRCULATION; COMPLICATIONS; SURGERY
AB Background Application of negative pressure wound therapy (NPWT) on free flaps not only reduces edema but also increases the pressure from outside. The impact of these opposite effects on flap perfusion remains elusive. This study evaluates the NPWT system's influence on macro- and microcirculation of free flaps and edema reduction to better assess the clinical value of this therapy in microsurgical reconstructions.Methods In this open-label, prospective cohort study, a total of 26 patients with free gracilis muscle flaps for distal lower extremity reconstruction were included. Flaps were covered with an NPWT (13 patients) or a conventional, fatty gauze dressing (13 patients) for 5 postoperative days (PODs). Changes in flap perfusion were analyzed by laser Doppler flowmetry, remission spectroscopy, and an implanted Doppler probe. Flap volume as a surrogate parameter for flap edema was evaluated by three-dimensional (3D) scans.Results No flap showed clinical evidence of circulatory disturbances. The groups showed significant differences in the dynamic of macrocirculatory blood flow velocity with an increase in the NPWT group and a decelerated flow in the control group from PODs 0 to 3 and PODs 3 to 5. No significant differences in microcirculation parameters were observed. 3D scans for estimation of edema development demonstrated significant differences in volume dynamics between the groups. Flap volume of the controls increased, while the volume in the NPWT group decreased during the first 5 PODs. The volume of NPWT-treated flaps decreased even further after NPWT removal from PODs 5 to 14 and significantly more than the flap volume in the control group.Conclusion NPWT is a safe form of dressing for free muscle flaps that enhances blood flow and results in a sustainable edema reduction. The use of NPWT dressings for free flaps should therefore be considered not only as a pure wound covering but also as a supportive therapy for free tissue transfer.
C1 [Dornseifer, Ulf; Pfeiler, Peter Paul; Kargl, Lukas] Isar Klinikum, Dept Plast Reconstruct & Aesthet Surg, Munich, Germany.
   [Moog, Philipp] Tech Univ Munich, Clin Plast Reconstruct & Hand Surg, Klinikum Rechts Isar, Munich, Germany.
   [Schilling, Arndt F.] Univ Med Ctr Gottingen, Dept Trauma Surg Orthoped & Plast Surg, Gottingen, Germany.
   [Ninkovic, Milomir] Bogenhausen Acad Teaching Hosp, Dept Plast Reconstruct Hand & Burn Surg, Munich, Germany.
   [Dornseifer, Ulf] Isar Klinikum, Dept Plast Reconstruct & Aesthet Surg, Sonnenstr 24-26, D-80331 Munich, Germany.
C3 Technical University of Munich; University of Gottingen; University of
   Gottingen Hospital; Munchen Klinik
RP Dornseifer, U (通讯作者)，Isar Klinikum, Dept Plast Reconstruct & Aesthet Surg, Sonnenstr 24-26, D-80331 Munich, Germany.
OI Schilling, Arndt/0000-0001-7022-1069
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NR 41
TC 14
Z9 16
U1 0
U2 1
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD MAR
PY 2024
VL 40
IS 03
BP 197
EP 204
DI 10.1055/a-2110-0421
EA JUL 2023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IX5M3
UT WOS:001037214700001
PM 37315931
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Orgill, DP
   McNulty, AK
AF Orgill, Dennis P.
   McNulty, Amy K.
TI Theoretical and Pre-Clinical Models of Vacuum Assisted Closure
SO SURGICAL INNOVATION
LA English
DT Article
DE biomedical engineering; general surgery; simulation; surgical education
ID PRESSURE WOUND THERAPY; SALINE INSTILLATION
AB Vacuum Assisted Closure (VAC) has changed how physicians treat complex and chronic wounds. For over 20 years, we have studied the mechanism of action of these devices in both an academic based research laboratory and in an industry-based laboratory.We performed a literature review of the theoretical and pre-clinical published studies from the two labs which related to the biomechanics of open pore reticulated polyurethane interfaces.The VAC device applies a direct mechanical interface to the wound surface. The interaction of the foam under suction with the wound surface causes surface deformation and cell stretch. The suction removes fluid from the tissues. There are increases in angiogenesis with better vessel morphology than standard dressings. The effect is dependent on the pore size of the foam, the pressure of application and the waveform of application. Undoubtedly, patient factors such as age, diabetes and radiation affect the response.Pre-clinical studies can help in the design and optimization of mechanical-based wound healing devices. Current work on the effects of these devices on lymphatics and scarring are areas of active investigation.
C1 [Orgill, Dennis P.] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Boston, MA USA.
   [McNulty, Amy K.] 3M Co, Med Solut Div, Res & Dev, St Paul, MN USA.
   [McNulty, Amy K.] 3M Co, Med Solut Div, Ctr 3M, Res & Dev, 270-3A-04, St Paul, MN 55144 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; 3M; 3M
RP McNulty, AK (通讯作者)，3M Co, Med Solut Div, Ctr 3M, Res & Dev, 270-3A-04, St Paul, MN 55144 USA.
EM akmcnulty@mmm.com
RI Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310; McNulty, Amy/0000-0001-6656-3103
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NR 15
TC 2
Z9 2
U1 1
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD AUG
PY 2023
VL 30
IS 4
BP 533
EP 537
DI 10.1177/15533506221142690
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA O4BZ3
UT WOS:001043297700017
PM 36446390
DA 2026-07-24
ER
PT J
AU Älgå, A
   Malmstedt, J
   Fagerdahl, AM
AF Alga, Andreas
   Malmstedt, Jonas
   Fagerdahl, Ann-Mari
TI Wound specific quality of life after blast or gunshot injury: Validation
   of the wound QoL instrument
SO PLOS ONE
LA English
DT Article
ID TRANSLATION; MORTALITY; THERAPY; DISEASE
AB Background
   Acute blast or gunshot wounds have a negative effect on the patients' health related quality of life (HRQoL). No validated instrument exists to assess the HRQoL of patients with such wounds. Therefore, we aimed to test and validate a subscale of an existing HRQoL instrument among patients with acute blast or gunshot wounds.
   Methods
   We used data from a randomized controlled trial comparing negative pressure wound therapy with standard treatment of civilian adults with acute extremity blast or gunshot wounds. We evaluated the reliability (internal consistency, stability) and validity of the body subscale of the Wound QoL instrument using the World Health Organisation 20 question self-reporting questionnaire as gold standard.
   Results
   A total of 152 participants were included in the study. The participants were predominantly (93.4%) male, and median age was 29.0 years (IQR 21.0-34.0). The internal consistency was acceptable while a test-retest analysis indicated instability in the Wound QoL instrument. The content validity of the instrument was considered satisfactory; however, the criterion validity was found to be insufficient.
   Conclusions
   Our results indicate that Wound QoL is a promising instrument for the assessment of wound specific HRQoL among patients with acute blast or gunshot wounds. Further testing and validation is needed.
C1 [Alga, Andreas; Malmstedt, Jonas; Fagerdahl, Ann-Mari] Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden.
   [Alga, Andreas] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
C3 Sodersjukhuset Hospital; Karolinska Institutet; Karolinska Institutet
RP Älgå, A (通讯作者)，Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden.; Älgå, A (通讯作者)，Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
EM andreas.alga@ki.se
RI Älgå, Andreas/B-1070-2019
OI Älgå, Andreas/0000-0001-5245-7668
FU Swedish National Board of Health and Welfare; Stockholm County Council
   (ALF grant)
FX AA received funding from the Swedish National Board of Health and
   Welfare, and the Stockholm County Council (ALF grant). The funders did
   not play any role in the study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
CR Al-Subaie AS, 1998, ANN SAUDI MED, V18, P308, DOI 10.5144/0256-4947.1998.308
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NR 29
TC 2
Z9 4
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 31
PY 2022
VL 17
IS 10
AR e0277094
DI 10.1371/journal.pone.0277094
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O6MF8
UT WOS:001044919700056
PM 36315560
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kirkham, AM
   Candeliere, J
   McIsaac, DI
   Stelfox, HT
   Dubois, L
   Gill, HL
   Brandys, T
   Nagpal, SK
   Roberts, DJ
AF Kirkham, Aidan M.
   Candeliere, Jasmine
   McIsaac, Daniel I.
   Stelfox, Henry T.
   Dubois, Luc
   Gill, Heather L.
   Brandys, Timothy
   Nagpal, Sudhir K.
   Roberts, Derek J.
TI Efficacy of Strategies Intended to Prevent Surgical Site Infection After
   Lower Limb Revascularization Surgery A Systematic Review and
   Meta-Analysis of Randomized Controlled Trials
SO ANNALS OF SURGERY
LA English
DT Review
DE lower limb revascularization surgery; meta-analysis; peripheral artery
   disease; surgical site infection; systematic review
ID PRESSURE WOUND THERAPY; VASCULAR-SURGERY; RISK-FACTORS; CLINICAL-TRIAL;
   GROIN WOUNDS; SKIN CLOSURE; DOUBLE-BLIND; PROPHYLAXIS; MULTICENTER;
   GENTAMICIN
AB Objective:The objective of this study is to evaluate the efficacy of strategies intended to prevent surgical site infection (SSI) after lower limb revascularization surgery. Background:SSIs are common, costly complications of lower limb revascularization surgery associated with significant morbidity and mortality. Methods:We searched MEDLINE, EMBASE, CENTRAL, and Evidence-Based Medicine Reviews (inception to April 28, 2022). Two investigators independently screened abstracts and full-text articles, extracted data, and assessed the risk of bias. We included randomized controlled trials (RCTs) that evaluated strategies intended to prevent SSI after lower limb revascularization surgery for peripheral artery disease. We used random-effects models to pool data and GRADE to assess certainty. Results:Among 6258 identified citations, we included 26 RCTs (n=4752 patients) that evaluated 12 strategies to prevent SSI. Preincision antibiotics [risk ratio (RR)=0.25; 95% CI, 0.11-0.57; n=4 studies; I-2 statistic=7.1%; high certainty] and incisional negative-pressure wound therapy (iNPWT) (RR=0.54; 95% CI, 0.38-0.78; n=5 studies; I-2 statistic=7.2%; high certainty) reduced pooled risk of early (& LE;30 days) SSI. iNPWT also reduced the risk of longer-term (>30 days) SSI (pooled-RR=0.44; 95% CI, 0.26-0.73; n=2 studies; I-2=0%; low certainty). Strategies with uncertain effects on risk of SSI included preincision ultrasound vein mapping (RR=0.58; 95% CI, 0.33-1.01; n=1 study); transverse groin incisions (RR=0.33; 95% CI, 0.097-1.15; n=1 study), antibiotic-bonded prosthetic bypass grafts (RR=0.74; 95% CI, 0.44-1.25; n=1 study; n=257 patients), and postoperative oxygen administration (RR=0.66; 95% CI, 0.42-1.03; n=1 study) (low certainty for all). Conclusions:Preincision antibiotics and iNPWT reduce the risk of early SSI after lower limb revascularization surgery. Confirmatory trials are required to determine whether other promising strategies also reduce SSI risk.
C1 [Kirkham, Aidan M.; McIsaac, Daniel I.; Roberts, Derek J.] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
   [Kirkham, Aidan M.; Brandys, Timothy; Nagpal, Sudhir K.; Roberts, Derek J.] Univ Ottawa, Dept Surg, Div Vasc & Endovasc Surg, Ottawa, ON, Canada.
   [Kirkham, Aidan M.; Candeliere, Jasmine; McIsaac, Daniel I.; Roberts, Derek J.] Ottawa Hosp, Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
   [McIsaac, Daniel I.] Univ Ottawa, Ottawa Hosp, Dept Anesthesiol, Ottawa, ON, Canada.
   [McIsaac, Daniel I.] Univ Ottawa, Ottawa Hosp, Dept Pain Med, Ottawa, ON, Canada.
   [McIsaac, Daniel I.; Dubois, Luc] Inst Clin Evaluat Sci, Toronto, ON, Canada.
   [Stelfox, Henry T.] Univ Calgary, OBrien Inst Publ Hlth, Dept Crit Care Med, Calgary, AB, Canada.
   [Dubois, Luc] Western Univ, Dept Surg, Div Vasc Surg, London, ON, Canada.
   [Dubois, Luc] Western Univ, Fac Med, Dept Epidemiol & Biostat, London, ON, Canada.
   [Gill, Heather L.] McGill Univ, Dept Surg, Div Vasc Surg, Montreal, PQ, Canada.
C3 University of Ottawa; University of Ottawa; University of Ottawa; Ottawa
   Hospital Research Institute; University of Ottawa; Ottawa Hospital
   Research Institute; University of Ottawa; Ottawa Hospital Research
   Institute; University of Toronto; Institute for Clinical Evaluative
   Sciences (ICES); University of Calgary; Western University (University
   of Western Ontario); Western University (University of Western Ontario);
   McGill University
RP Roberts, DJ (通讯作者)，Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.; Roberts, DJ (通讯作者)，Univ Ottawa, Dept Surg, Div Vasc & Endovasc Surg, Ottawa, ON, Canada.; Roberts, DJ (通讯作者)，Ottawa Hosp, Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
EM akirk032@uottawa.ca; jcand012@uottawa.ca; dmcisaac@toh.ca;
   tstelfox@ucalgary.ca; luc.dubois@lhsc.on.ca; heather.gill@mcgill.ca;
   tbrandys@toh.ca; snagpal@toh.ca; Derek.Roberts01@gmail.com
RI Kirkham, Aidan M/HBZ-9926-2022; Roberts, Derek/L-6229-2019
OI Kirkham, Aidan M/0000-0001-6432-3018; Roberts, Derek/0000-0001-6111-6291
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NR 74
TC 11
Z9 11
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD SEP
PY 2023
VL 278
IS 3
BP E447
EP E456
DI 10.1097/SLA.0000000000005867
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA O9TW8
UT WOS:001047180100018
PM 36994744
DA 2026-07-24
ER
PT J
AU Groenen, H
   Jalalzadeh, H
   Buis, DR
   Dreissen, YEM
   Goosen, JHM
   Griekspoor, M
   Harmsen, WJ
   Ijpma, FFA
   van der Laan, MJ
   Schaad, RR
   Segers, P
   van der Zwet, WC
   de Jonge, SW
   Orsini, RG
   Eskes, AM
   Wolfhagen, N
   Boermeester, MA
AF Groenen, Hannah
   Jalalzadeh, Hasti
   Buis, Dennis R.
   Dreissen, Yasmine E. M.
   Goosen, Jon H. M.
   Griekspoor, Mitchel
   Harmsen, Wouter J.
   Ijpma, Frank F. A.
   van der Laan, Maarten J.
   Schaad, Roald R.
   Segers, Patrique
   van der Zwet, Wil C.
   de Jonge, Stijn W.
   Orsini, Ricardo G.
   Eskes, Anne M.
   Wolfhagen, Niels
   Boermeester, Marja A.
TI Incisional negative pressure wound therapy for the prevention of
   surgical site infection: an up-to-date meta-analysis and trial
   sequential analysis
SO ECLINICALMEDICINE
LA English
DT Article
DE Surgical site infections; Prevention; Incisional negative pressure wound
   therapy; iNPWT
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE;
   FOR-DISEASE-CONTROL; HIGH-RISK; CESAREAN DELIVERY; OBESE WOMEN; PRIMARY
   HIP; COMPLICATIONS; SURGERY; DRESSINGS
AB Background The evidence on prophylactic use of negative pressure wound therapy on primary closed incisional wounds (iNPWT) for the prevention of surgical site infections (SSI) is confusing and ambiguous. Implementation in daily practice is impaired by inconsistent recommendations in current international guidelines and published meta-analyses. More recently, multiple new randomised controlled trials (RCTs) have been published. We aimed to provide an overview of all meta-analyses and their characteristics; to conduct a new and up-to-date systematic review and meta-analysis and Grading of Recommendations Assessment, Development and Evaluation (GRADE) assessment; and to explore the additive value of new RCTs with a trial sequential analysis (TSA). Methods PubMed, Embase and Cochrane CENTRAL databases were searched from database inception to October 24, 2022. We identified existing meta-analyses covering all surgical specialties and RCTs studying the effect of iNPWT compared with standard dressings in all types of surgery on the incidence of SSI, wound dehiscence, reoperation, seroma, hematoma, mortality, readmission rate, skin blistering, skin necrosis, pain, and adverse effects of the intervention. We calculated relative risks (RR) with corresponding 95% confidence intervals (CI) using a Mantel-Haenszel random-effects model. We assessed publication bias with a comparison-adjusted funnel plot. TSA was used to assess the risk of random error. The certainty of evidence was evaluated using the Cochrane Risk of Bias-2 (RoB2) tool and GRADE approach. This study is registered with PROSPERO, CRD42022312995. Findings We identified eight previously published general meta-analyses investigating iNPWT and compared their results to present meta-analysis. For the updated systematic review, 57 RCTs with 13,744 patients were included in the quantitative analysis for SSI, yielding a RR of 0.67 (95% CI: 0.59-0.76, I2 = 21%) for iNPWT compared with standard dressing. Certainty of evidence was high. Compared with previous meta-analyses, the RR stabilised, and the confidence interval narrowed. In the TSA, the cumulative Z-curve crossed the trial sequential monitoring boundary for benefit, confirming the robustness of the summary effect estimate from the meta-analysis. Interpretation In this up-to-date meta-analysis, GRADE assessment shows high-certainty evidence that iNPWT is effective in reducing SSI, and uncertainty is less than in previous meta-analyses. TSA indicated that further trials are unlikely to change the effect estimate for the outcome SSI; therefore, if future research is to be conducted on iNPWT, it is crucial to consider what the findings will contribute to the existing robust evidence. Copyright & COPY; 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Groenen, Hannah; Jalalzadeh, Hasti; de Jonge, Stijn W.; Eskes, Anne M.; Wolfhagen, Niels; Boermeester, Marja A.] Amsterdam UMC Locat Univ Amsterdam, Dept Surg, Meibergdreef 9, Amsterdam, Netherlands.
   [Groenen, Hannah; Jalalzadeh, Hasti; de Jonge, Stijn W.; Eskes, Anne M.; Wolfhagen, Niels; Boermeester, Marja A.] Amsterdam Gastroenterol Endocrinol & Metab, Amsterdam, Netherlands.
   [Groenen, Hannah; Jalalzadeh, Hasti; Buis, Dennis R.; Dreissen, Yasmine E. M.; Goosen, Jon H. M.; Griekspoor, Mitchel; Harmsen, Wouter J.; Ijpma, Frank F. A.; van der Laan, Maarten J.; Schaad, Roald R.; Segers, Patrique; van der Zwet, Wil C.; Wolfhagen, Niels; Boermeester, Marja A.] Dutch Natl Guideline Grp Prevent Postoperat Surg S, Amsterdam, Netherlands.
   [Buis, Dennis R.; Dreissen, Yasmine E. M.] Amsterdam UMC Locat Univ Amsterdam, Dept Neurosurg, Meibergdreef 9, Amsterdam, Netherlands.
   [Goosen, Jon H. M.] Sint Maartensklin, Dept Orthoped Surg, Ubbergen, Netherlands.
   [Griekspoor, Mitchel; Harmsen, Wouter J.] Dutch Assoc Med Specialists, Utrecht, Netherlands.
   [Ijpma, Frank F. A.] Univ Med Ctr Groningen, Dept Surg, Div Trauma Surg, Groningen, Netherlands.
   [van der Laan, Maarten J.] Univ Med Ctr Groningen, Dept Surg, Groningen, Netherlands.
   [Schaad, Roald R.] Leiden Univ, Med Ctr, Dept Anesthesiol, Leiden, Netherlands.
   [Schaad, Roald R.] Dutch Assoc Anesthesiol NVA, Utrecht, Netherlands.
   [Segers, Patrique] Maastricht Univ, Med Ctr, Dept Cardiothorac Surg, Maastricht, Netherlands.
   [van der Zwet, Wil C.] Maastricht Univ, Med Ctr, Dept Med Microbiol Infect Dis & Infect Prevent, Maastricht, Netherlands.
   [Orsini, Ricardo G.] Maastricht Univ, Med Ctr, Dept Surg, Maastricht, Netherlands.
   [Eskes, Anne M.] Amsterdam Univ Appl Sci, Fac Hlth, Ctr Expertise Urban Vital, Amsterdam, Netherlands.
   [Eskes, Anne M.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia.
   [Eskes, Anne M.] Griffith Univ, Sch Nursing & Midwifery, Gold Coast, Australia.
C3 Sint Maartens Clinic; University of Groningen; University of Groningen;
   Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Maastricht University; Maastricht University;
   Maastricht University; Menzies Health Institute Queensland; Griffith
   University; Griffith University
RP Boermeester, MA (通讯作者)，Amsterdam UMC Locat Univ Amsterdam, Dept Surg, Meibergdreef 9, Amsterdam, Netherlands.
EM m.a.boermeester@amsterdamumc.nl
RI Buis, Dennis Robert/L-3247-2019; Eskes, Anne Maria/HKV-3276-2023; van
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   Wil/CAI-0427-2022; de Jonge, Stijn/PRR-5245-2026
OI Buis, Dennis Robert/0000-0002-7411-5383; Eskes, Anne
   Maria/0000-0003-1605-0195; de Jonge, Stijn/0000-0003-0693-3111; van der
   Laan, Maarten/0000-0002-3125-1342; Jalalzadeh, Hasti/0000-0001-6035-9144
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NR 108
TC 46
Z9 51
U1 1
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-5370
J9 ECLINICALMEDICINE
JI EClinicalMedicine
PD AUG
PY 2023
VL 62
AR 102105
DI 10.1016/j.eclinm.2023.102105
EA JUL 2023
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA P1JV1
UT WOS:001048281800001
PM 37538540
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Zhao, Y
   Zhang, M
   Zhang, CL
   Yan, HW
AF Zhao, Yi
   Zhang, Mi
   Zhang, Chuanlin
   Yan, Hongwei
TI Effect of local oxygen therapy combined with vacuum sealing drainage on
   the healing of stage IV sacrococcygeal pressure ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE local oxygen therapy; sacrococcygeal region; stage IV pressure ulcers;
   VSD; wound healing
ID WOUND THERAPY; IMPACT
AB The present study aimed to investigate the effect of local oxygen therapy combined with vacuum sealing drainage (VSD) on the healing of stage IV pressure ulcers sacrococcygeal. In this prospective study, we included a total of 98 patients with stage IV sacrococcygeal pressure ulcers in our hospital between February 2021 and June 2022. The patients enrolled were randomly and equally divided into two groups: the study group (undergoing local oxygen therapy combined with VSD treatment) and the control group (receiving conventional treatment). The wound healing time and hospital stay were compared between the two groups. Additionally, the wound area, tissue type, wound exudation and pain intensity were assessed before treatment, 10, 20, 30 and 40 days after treatment. The incidence of complications was also calculated. The study group demonstrated significantly shorter wound healing time and hospital stays compared to the control group (p < 0.05). Before treatment, there were no significant differences in terms of wound area, tissue type and wound exudation between the two groups (p > 0.05); after 10, 20, 30 and 40 days of treatment, however, evidently smaller wound areas, improved tissue types and reduced wound exudation were observed in the study group compared to the control group (p < 0.05). Furthermore, the study group exhibited increased microvascular count compared to the control group (p < 0.05). Before treatment, there was no significant difference in pain intensity between the two groups (p > 0.05), whereas markedly lower pain intensity was seen in the study group than in the control group after 10, 20, 30 and 40 days of treatment (p < 0.05). The incidence of complications did not significantly differ between the two groups after 40 days of treatment (p > 0.05). Local oxygen therapy combined with VSD was found to effectively accelerate the healing process of stage IV sacrococcygeal pressure ulcers, leading to shorter hospital stays and improved patient prognosis. This combined therapy shows promise for widespread application in clinical practice.
C1 [Zhao, Yi; Yan, Hongwei] Hubei Univ Med, Renmin Hosp, Dept Burn & Plast Surg, Shiyan, Peoples R China.
   [Zhang, Mi] Hubei Univ Med, Renmin Hosp, Dept Dermatol, Shiyan, Peoples R China.
   [Zhang, Chuanlin] Hubei Univ Med, Renmin Hosp, Dept Cardiol, Shiyan, Peoples R China.
   [Yan, Hongwei] Hubei Univ Med, Renmin Hosp, Dept Burn & Plast Surg, 39 Chaoyang Middle Rd, Shiyan 442000, Hubei, Peoples R China.
C3 Hubei University of Medicine; Hubei University of Medicine; Hubei
   University of Medicine; Hubei University of Medicine
RP Yan, HW (通讯作者)，Hubei Univ Med, Renmin Hosp, Dept Burn & Plast Surg, 39 Chaoyang Middle Rd, Shiyan 442000, Hubei, Peoples R China.
EM 312698647@qq.com
RI yan, hongwei/PMF-7847-2026
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NR 28
TC 8
Z9 11
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2023
VL 20
IS 10
BP 4253
EP 4261
DI 10.1111/iwj.14327
EA AUG 2023
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CH3W9
UT WOS:001048642700001
PM 37574848
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, JH
   Chang, ZQ
AF Li, Jianhua
   Chang, Zhengqi
TI Case Report: A spinal infection with bilateral psoas abscesses was
   treated with NPWT to enhance the local infection by increasing the
   infiltration of neutrophil cells and draining the pus
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE neutrophil; spinal infections; bilateral psoas abscess; lateral
   approach; negative pressure wound therapy (NPWT)
ID POSTERIOR DEBRIDEMENT; INSTRUMENTATION; MANAGEMENT; DRAINAGE; THERAPY
AB Treatment of spinal brucellosis with bilateral psoas abscess is a challenging clinical endeavor. We retrospectively evaluated a case of lumbar infection and bilateral psoas abscess, and was effectively managed through a unilateral extreme lateral approach with the aid of NPWT for bilateral drainage. We hypothesize that NPWT can influence the Piezo1 receptor of neutrophils and further influence the interaction between neutrophils and endothelial cells to promote the clearance of infected lesions, and this phenomenon is also observed in pathological slides. This proves that NPWT can rapidly enhance the recruitment of neutrophils in the infected area and improve the local immune response, and after a year of reassessment and tracking, Bilateral drainage using NPWT via a unilateral Extreme Lateral Approach could acquire satisfactory surgical outcomes, can be used as a treatment modality for lumbar infection with bilateral psoas abscesses.
C1 [Li, Jianhua; Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
EM 26766771@qq.com
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NR 21
TC 5
Z9 6
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD AUG 4
PY 2023
VL 13
AR 1228376
DI 10.3389/fcimb.2023.1228376
PG 6
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA P3GS4
UT WOS:001049564900001
PM 37600941
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Baptista, AM
   De Camargo, AFD
   Caiero, MT
   Torres, JSD
   Narciso, JH
   Silva, MRD
AF Baptista, Andre Mathias
   De Camargo, Andre Ferrari De Franca
   Caiero, Marcelo Tadeu
   Torres Filho, Jose Saint Clair De Sousa
   Narciso, Jorge Henrique
   Silva, Marcela Rocha Dias
TI ROLE OF INCISIONAL VACUUM THERAPY IN ENDOPROSTHETIC BONE RECONSTRUCTION
   SURGERY
SO ACTA ORTOPEDICA BRASILEIRA
LA English
DT Article
DE Negative Pressure Wound Therapy; Prostheses and Implants; Osteosarcoma
ID PRESSURE WOUND THERAPY; 1ST REVISION; INFECTIONS
AB Reconstructive surgery with endoprostheses is the chosen method for treating bone malignancies. Postoperative infections are frequent complications, and their treatment involves prolonged hospital stays and antibiotic therapy. Among the advancements aimed at reducing the rate of postoperative infection, the use of incisional negative pressure therapy (iNPT) has shown promising results, with no reports in the literature regarding its use in patients with such conditions. Objective: To evaluate the effectiveness of iNPT in reducing postoperative complications in surgeries for resection of bone tumors associated with modular endoprosthesis reconstruction. Methods: Retrospective case series of 16 patients diagnosed with osteosarcoma, who underwent resection and reconstruction with endoprosthesis associated with iNPT during the postoperative period. Follow-up was performed for a period of six months, and the evaluated outcomes were the incidence of postoperative infection and complications of the surgical wound. Results: The use of iNPT for a postoperative period of seven days resulted in only three (18.7%) bone malignancies.
C1 [Baptista, Andre Mathias; De Camargo, Andre Ferrari De Franca; Caiero, Marcelo Tadeu; Torres Filho, Jose Saint Clair De Sousa; Narciso, Jorge Henrique; Silva, Marcela Rocha Dias] Univ Sao Paulo, Hosp Clin, Fac Med, Inst Ortopedia & Traumatol IOT HCFMUSP,Grp Oncol O, Sao Paulo, SP, Brazil.
   [Baptista, Andre Mathias] Rua Dr Ovidio Pires Campos 333, BR-05403010 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo
RP Baptista, AM (通讯作者)，Rua Dr Ovidio Pires Campos 333, BR-05403010 Sao Paulo, SP, Brazil.
EM andre.ferrari@fm.usp.br
RI Baptista, Ane Mathias/AAD-6498-2019
OI Baptista, Ane Mathias/0000-0002-0830-4602; Caiero,
   Marcelo/0000-0003-4891-0276; Narciso, Jorge
   Henrique/0000-0003-0548-836X; Tôrres Filho, José Saint Clair de
   Sousa/0000-0001-9942-6818; Camargo, André Ferrari de
   França/0000-0003-0317-3807
CR Broex ECJ, 2009, J HOSP INFECT, V72, P193, DOI 10.1016/j.jhin.2009.03.020
   Cooper HJ, 2018, INJURY, V49, P386, DOI 10.1016/j.injury.2017.11.010
   Gustafsson R, 2007, EUROPEAN WOUND MANAG
   Hammond C, 2008, EVIDENCE REV VACUUM, P1
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   Nherera LM, 2017, WOUND REPAIR REGEN, V25, P474, DOI 10.1111/wrr.12530
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   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
NR 16
TC 0
Z9 0
U1 0
U2 3
PU ATHA COMUNICACAO & EDITORA
PI SAO PAULO
PA RUA MACHADO BITTENCOURT, 190-40 ANDAR, CONJ 410, SAO PAULO, Sao Paulo,
   BRAZIL
SN 1413-7852
EI 1809-4406
J9 ACTA ORTOP BRAS
JI Acta Ortop. Bras.
PY 2023
VL 31
IS 4
AR e260330
DI 10.1590/1413-785220233104e260330
PG 3
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA P4FS3
UT WOS:001050225900005
PM 37547234
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hunili, T
   Erden, S
AF Hunili, Tugba
   Erden, Sevilay
TI Effect of TENS on Vacuum Pain in Acute Soft Tissue Trauma
SO PAIN MANAGEMENT NURSING
LA English
DT Article
ID ELECTRICAL NERVE-STIMULATION; PRESSURE WOUND THERAPY; INTENSITY; REDUCE
AB Backround: In the literature, the effect of TENS on acute pain has been investigated, and no study has been found on its effect on pain associated with VAC application. This randomized controlled trial was designed to assess the efficacy of TENS application in pain caused by vacuum applied in acute soft tissue trauma of the lower extremity. Design and Settings: The study included 40 patients: 20 in the control group, and 20 in the experimental group and was carried out in a university hospital's plastic and reconstructive surgery clinic. Data for the study were gathered using the Patient Information form and the Pain Assessment form. Conventional TENS lasting 30 minutes was applied to the experimental group patients 1 hour before vacuum (vacuum assisted closure [VAC]) insertion and removal by the researcher, and TENS was not applied to the control group. The "Numerical Pain Scale" was used to assess pain in both groups before and after TENS application. In the statistical analysis of the data, the SPSS 23.0 package program was used. In all tests, p < .005 was considered statistically significant. Results: The experimental and control groups of the patients included in the study were homogeneous in terms of demographic characteristics ( p > .05). Furthermore, when the pain levels of the groups were compared over time, it was discovered that the pain levels of the control group were significantly higher than the experimental group at the times of VAC insertion (T3) and VAC removal (T6) ( p < .05). Bonferroni test, one of the post hoc tests, was used to determine in-group significance in both the experimental and control groups, and it was discovered that the difference was between T6 and all other times (T6-T1, T2, T3, T4, T5). Conclusions: The results obtained from our study showed that TENS reduced the pain caused by vacuum applied in acute soft tissue trauma of the lower extremity. It is thought that TENS may not replace traditional analgesics but may help reduce the level of pain and contribute to healing by increasing comfort during painful procedures. & COPY; 2023 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.
C1 [Hunili, Tugba] Cukurova Univ, Balcali Hosp, Plast Surg Dept, Adana, Turkiye.
   [Erden, Sevilay] Fac Hlth Sci, Dept Nursing Adana, Adana, Turkiye.
   [Erden, Sevilay] Fac Hlth Sci, Dept Nursing Adana, TR-01380 Adana, Turkiye.
C3 Cukurova University
RP Erden, S (通讯作者)，Fac Hlth Sci, Dept Nursing Adana, TR-01380 Adana, Turkiye.
EM sevilaygil@gmail.com
FU Cukurova University, Scientific Research Projects Coordination Unit
   [TYL-2019-12404]
FX This study was financially supported by Cukurova University, Scientific
   Research Projects Coordination Unit with the protocol number of
   TYL-2019-12404.
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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   Xue X, 2021, INT WOUND J, V18, P639, DOI 10.1111/iwj.13565
NR 26
TC 3
Z9 3
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1524-9042
EI 1532-8635
J9 PAIN MANAG NURS
JI Pain Manag. Nurs.
PD AUG
PY 2023
VL 24
IS 4
DI 10.1016/j.pmn.2023.02.001
EA AUG 2023
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA P6PT2
UT WOS:001051882600001
PM 36907690
DA 2026-07-24
ER
PT J
AU Melnychuk, I
   Juriga, J
AF Melnychuk, Igor
   Juriga, Julia
TI "Soap Scrap" Technique: A Tissue-Preserving Approach to Treating Wounds
   with Undermining or Pockets
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE closed-incision negative-pressure therapy; edge trenching; epibole; Fick
   diffusion principle; modified negative-pressure therapy; multilayered
   compression; negative-pressure wound therapy; soap scrap; undermining;
   wound pockets; wound edge; wound remodeling
AB This retrospective case series introduces a tissue-preserving approach to treat complicated wounds with undermined edges or wounds with pockets. Wounds with undermining or pockets are commonly encountered in clinical practice and can be difficult to manage when trying to achieve wound closure. Traditionally, epibolic edges need to be resected or cauterized with silver nitrate, whereas wound undermining or pockets need to be resected or unroofed. The method described herein consists of three components: sharp debridement of all undermined areas or inside walls of wound pockets, compression, and immobilization. Compression can be performed using multilayered compression alone, modified negative-pressure therapy, or both. Immobilization of all wound layers can be achieved using a brace, removable Cam Walker, or a cast.
   This article reports on 11 patients who had unfavorable upper and lower extremity wounds with undermined areas or wound pockets who were treated using this methodology. The average patient age was 73 years, and the average wound depth was 1.12 cm. The average undermined area was 1.7 (range, 0.2-5.0) cm. Wounds healed in an average of 9.1 weeks; all wounds healed between 3 and 15 weeks. This series demonstrates a novel tissue-preserving approach to treating wounds with undermining or wounds with pockets using debridement, immobilization, and compression.
C1 [Melnychuk, Igor] Edward Via Coll Osteopath Med Carolinas, Blacksburg, VA 24060 USA.
   [Melnychuk, Igor] Charles George VA Med Ctr, Wound Care Dept, Asheville, NC 28805 USA.
   [Juriga, Julia] Nova Southeastern Univ, Ft Lauderdale, FL USA.
C3 Edward Via College of Osteopathic Medicine (VCOM); Nova Southeastern
   University
RP Melnychuk, I (通讯作者)，Edward Via Coll Osteopath Med Carolinas, Blacksburg, VA 24060 USA.; Melnychuk, I (通讯作者)，Charles George VA Med Ctr, Wound Care Dept, Asheville, NC 28805 USA.
CR Castonguay G, 2008, OSTOMY WOUND MANAG, V54, P50
   Fowler AL, 2020, SURG-J R COLL SURG E, V18, P241, DOI 10.1016/j.surge.2019.10.007
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   Norman G, 2020, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD009261.pub6, 10.1002/14651858.CD009261.pub5]
   Pappalardo Vincenzo, 2019, SURG TECHNOL INT, V34
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   Yamamoto T, 2015, J PLAST RECONSTR AES, V68, P1432, DOI 10.1016/j.bjps.2015.06.004
NR 11
TC 6
Z9 6
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD SEP
PY 2023
VL 36
IS 9
BP 495
EP 501
DI 10.1097/ASW.0000000000000008
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA P7EM0
UT WOS:001052268200014
PM 37530574
DA 2026-07-24
ER
PT J
AU Singh, H
   Avudaiappan, M
   Kharel, J
   Irrinki, S
   Kumar, H
   Savlania, A
   Sharma, V
   Gupta, V
   Yadav, TD
   Gupta, R
AF Singh, Harjeet
   Avudaiappan, Mohanasundaram
   Kharel, Jyoti
   Irrinki, Santosh
   Kumar, Hemant
   Savlania, Ajay
   Sharma, Vishal
   Gupta, Vikas
   Yadav, Thakur Deen
   Gupta, Rajesh
TI Negative pressure wound therapy versus standard care for incisional
   laparotomy subcutaneous wounds in gastrointestinal perforations: A
   randomized controlled study
SO SURGERY
LA English
DT Article
ID SURGICAL SITE INFECTION; DELAYED PRIMARY CLOSURE; TRIAL; PREVENTION
AB Background: Surgical site infections after gastrointestinal perforation with peritonitis have significant morbidity, increased hospital stays, and cost of treatment. The appropriate management of these wounds is still debatable.Methods: Patients undergoing surgery for gastrointestinal perforation with peritonitis via midline inci-sion were screened for inclusion. After the closure of the midline fascia, patients were randomized into an open negative pressure wound therapy group (application of negative pressure wound therapy and attempted delayed closure at day 4) or a standard care group (no negative pressure wound therapy and attempted delayed closure at day 4). Postoperative outcomes, including surgical site infection till 30 days, were compared between the groups. This was assessed by an independent assessor not involved in the study for delayed closure. Although a priori sample size was calculated, an interim analysis was per-formed due to slow recruitment during the COVID pandemic. After interim analysis, a continuation of the trial was deemed unethical and terminated.Results: Ninety-six patients were assessed, and 69 were randomized (34 in the negative pressure wound therapy group and 31 in the standard care group). The age, body mass index, comorbidities, blood loss, operative time, and stoma formation were comparable. The surgical site infection was significantly lower in the negative pressure wound therapy group compared to the standard care group (6 [18%] vs 19 [61%], P < .01). The number needed to prevent 1 surgical site infection was 2.3. In a subgroup analysis, the use of negative pressure wound therapy also significantly decreased the rate of surgical site infection in stoma patients (4 [30.7%] vs 9 [69.3%], P 1/4 .03).Conclusion: Open negative pressure wound therapy significantly decreases the incisional surgical site infection rate in patients with a dirty wound secondary to gastrointestinal perforation with peritonitis.& COPY; 2023 Elsevier Inc. All rights reserved.
C1 [Singh, Harjeet; Avudaiappan, Mohanasundaram; Kharel, Jyoti; Gupta, Vikas; Yadav, Thakur Deen; Gupta, Rajesh] Post Grad Inst Med Educ & Res, Dept Surg Gastroenterol, Chandigarh, India.
   [Irrinki, Santosh; Savlania, Ajay] Post Grad Inst Med Educ & Res, Dept Gen Surg, Chandigarh, India.
   [Kumar, Hemant] Manipal Hosp, Dept Surg Gastroenterol, Bangalore, India.
   [Sharma, Vishal] Post Grad Inst Med Educ & Res, Dept Gastroenterol, Chandigarh, India.
   [Singh, Harjeet] Post Grad Inst Med Educ & Res, Dept Surg Gastroenterol, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh; Post Graduate Institute of Medical Education &
   Research (PGIMER), Chandigarh; Post Graduate Institute of Medical
   Education & Research (PGIMER), Chandigarh
RP Singh, H (通讯作者)，Post Grad Inst Med Educ & Res, Dept Surg Gastroenterol, Chandigarh 160012, India.
EM harjeetsingh1982@gmail.com
RI ; Sharma, Vishal/B-9729-2011; yadav, thakur/AAK-5537-2021; KUMAR,
   HEMANT/PII-7632-2026
OI Singh, Harjeet/0000-0002-0748-9473; Sharma, Vishal/0000-0003-2472-3409; 
FU Post Graduate Institute of Medical Education and Research, Chandigarh
FX The work was supported by an intramural research grant from the
   institute (Post Graduate Institute of Medical Education and Research,
   Chandigarh) for purchasing NPWT dressing. The funder has no role in
   designing, data collection, or analysis.
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NR 23
TC 4
Z9 7
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD AUG
PY 2023
VL 174
IS 2
BP 291
EP 295
DI 10.1016/j.surg.2023.04.018
EA JUL 2023
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA P7YA4
UT WOS:001052779200001
PM 37183134
DA 2026-07-24
ER
PT J
AU Abbas, AAM
   McPherson, I
   Dunning, J
AF Abbas, Ahmed A. M.
   McPherson, Iain
   Dunning, Joel
TI Is vacuum-assisted closure therapy the main culprit in right ventricular
   rupture after deep sternal wound infection?
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE cardiac rupture; deep sternal wound infection; negative pressure wound
   therapy; NPWT; right ventricular rupture; vacuum assisted closure; VAC;
   wound; wound care; wound dressing; wound healing
ID CARDIAC RUPTURE; MEDIASTINITIS; PATIENT; MANAGEMENT; STERNOTOMY; INJURY;
   IMPACT; DAMAGE; RISK
AB Right ventricular rupture after deep sternal wound infection (DSWI) is a rare but fatal complication, and can occur with or without vacuum assisted closure (VAC) therapy. There is currently no strong evidence to suggest whether or not VAC therapy is a contributing factor to this complication. In total, 30 articles were retrieved and assessed through a systematic review strategy from 1953 to 2022. The keywords: 'vacuum assisted closure'; 'VAC'; 'negative pressure wound therapy'; 'deep sternal wound infection'; 'DSWI'; 'right ventricular rupture'; and 'cardiac rupture' were used in the search. Overall, 15 of the included articles satisfied the predefined eligibility criteria. Fatal right ventricular ruptures were reported in 18 (36%) out of 50 cases. In this article, the risk factors, mechanisms and management of right ventricular rupture are discussed. A novel view of the mechanism of VAC-associated right ventricular rupture is highlighted, with a focus on both pre- and intraoperative management.
C1 [Abbas, Ahmed A. M.; McPherson, Iain; Dunning, Joel] James Cook Univ Hosp, Middlesbrough, Cleveland, England.
C3 James Cook University Hospital
RP Abbas, AAM (通讯作者)，James Cook Univ Hosp, Middlesbrough, Cleveland, England.
EM hippocratep53@yahoo.com
OI Abbas, Ahmed/0009-0001-8506-9693
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NR 41
TC 0
Z9 0
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2023
VL 32
IS 8
BP 520
EP 526
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA P9TZ5
UT WOS:001054045600008
PM 37572337
DA 2026-07-24
ER
PT J
AU Pesic, S
   Tulencic-Egic, S
   Zwick, M
AF Pesic, Slobodan
   Tulencic-Egic, Snezana
   Zwick, Mihajlo
TI Above-knee amputation due to necrotizing fasciitis caused by a gas-
   producing strain of Escherichia coli and negative pressure
   therapy assisted closure of a large open wound
SO VOJNOSANITETSKI PREGLED
LA English
DT Article
DE amputation; surgical; diabetes mellitus; escherichia coli; necrotizing
   fasciitis; wound closure techniques
AB Introduction. Nonclostridial gas-forming soft tissue infec-tions (NGSTI) are rare, rapid progressive infections character-ized by high mortality and high amputation rates. Surgical deb-ridement is crucial in therapy, and it results in complex wounds that need to be closed in order to prevent secondary morbidity. Case report. Herein we present a case of NGSTI in a 68-year-old diabetic patient with acute thrombosis of pop-liteal artery aneurysm and radiological signs of gas in his right leg and the urinary bladder wall. The infection was caused by a gas-forming strain of Escherichia coli. In the early stage of the disease, the patient was treated with antibiotics and femoral amputation. A vacuum-assisted closure (VAC) treatment was applied to close the amputation wound. Administered VAC therapy resulted in primary wound closure without complica-tions 17 days after surgery. Conclusion. Negative pressure in-creases the clearance of fluid and infection from the wound but also increases wound contraction and approximation of skin flaps. To avoid extensive reconstructive surgery, VAC therapy can be a good adjunctive treatment for closing large open wounds in patients with NGSTI.
C1 [Pesic, Slobodan; Tulencic-Egic, Snezana; Zwick, Mihajlo] Gen Hosp Subotica, Dept Surg, Vasc Surg Div, Subotica, Serbia.
   [Pesic, Slobodan] Gen Hosp Subotica, Izvorska 3, Subotica 24000, Serbia.
RP Pesic, S (通讯作者)，Gen Hosp Subotica, Izvorska 3, Subotica 24000, Serbia.
EM spesic90@gmail.com
OI Pešić, Slobodan/0000-0002-3219-1396
CR Aggelidakis J, 2011, WORLD J EMERG SURG, V6, DOI 10.1186/1749-7922-6-28
   Ahn J, 2019, INT J LOW EXTR WOUND, V18, P114, DOI 10.1177/1534734619836464
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NR 18
TC 0
Z9 0
U1 0
U2 3
PU MILITARY MEDICAL ACAD-INI
PI BELGRADE
PA CRNOTRAVSKA 17, PO BOX 33-35, BELGRADE, 11040, SERBIA
SN 0042-8450
EI 2406-0720
J9 VOJNOSANIT PREGL
JI Vojnosanit. Pregl.
PY 2023
VL 80
IS 6
BP 534
EP 537
DI 10.2298/VSP220315074P
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q0SV1
UT WOS:001054709300001
OA gold
DA 2026-07-24
ER
PT J
AU Cantatore, F
   Pagliara, E
   Marcatili, M
   Bertuglia, A
AF Cantatore, Federica
   Pagliara, Eleonora
   Marcatili, Marco
   Bertuglia, Andrea
TI Negative-Pressure Wound Therapy (NPWT) in Horses: A Scoping Review
SO VETERINARY SCIENCES
LA English
DT Review
DE horses; NPWT; VAC therapy; wound; skin grafts
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; INFECTIONS; LAPAROTOMY
AB Obtaining a healthy wound environment that is conductive to healing in horses can be challenging. Negative-pressure wound therapy (NPWT) has been employed in humans to enhance wound healing for decades. The existing evidence for the effectiveness of NPWT remains uncertain in equine medicine. The aim of this review is to investigate NPWT applications and benefits in horses. A scoping review was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines for scoping reviews on three databases (PubMed, Web of Science-Thompson Reuters, and Wiley Online Library). Twenty-four manuscripts were considered. After removing duplicates, 17 papers underwent abstract screening. Of these, 16 + 1 (cited by others) were evaluated for eligibility according to PICOs, including no case reports/retrospective studies, four original articles, and three reviews. Fifteen manuscripts met the inclusion criteria. The focus of the articles was wound management; they included three reports of wounds communicating with synovial structures. Traumatic wounds and surgical-site infections are indications for NPWT. NPWT presents several advantages and few complications making it an attractive alternative to conventional wound management. However, randomized controlled trials should be performed to quantify the benefits and establish precise protocols in horses.
C1 [Cantatore, Federica; Marcatili, Marco] IVC Evidensia, Pool House Equine Clin, Fradley WS13 8RD, Lichfield, England.
   [Pagliara, Eleonora; Bertuglia, Andrea] Univ Turin, Dept Vet Sci, I-10095 Grugliasco, Italy.
C3 University of Turin
RP Cantatore, F (通讯作者)，IVC Evidensia, Pool House Equine Clin, Fradley WS13 8RD, Lichfield, England.
EM fedecantatore10@gmail.com; eleonora.pagliara@unito.it;
   marco.marcatili86@gmail.com; andrea.bertuglia@unito.it
RI PAGLIARA, ELEONORA/IAO-6053-2023; BERTUGLIA, Andrea/ABG-2212-2021
OI PAGLIARA, ELEONORA/0000-0002-5616-5918; BERTUGLIA,
   Andrea/0000-0002-4442-2622; Marcatili, Marco/0000-0002-5449-6780; ,
   federica/0000-0003-1745-6146
FU The authors would like to thank Richard Stephenson for the help with the
   English translation.
FX The authors would like to thank Richard Stephenson for the help with the
   English translation.
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NR 35
TC 6
Z9 7
U1 1
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2306-7381
J9 VET SCI
JI Vet. Sci.
PD AUG
PY 2023
VL 10
IS 8
AR 507
DI 10.3390/vetsci10080507
PG 13
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA Q2FO6
UT WOS:001055729000001
PM 37624295
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Horn, C
   Fierro, A
   Lantis, JC II
AF Horn, Callie
   Fierro, Allegra
   Lantis II, John C.
TI Use of Negative Pressure Wound Therapy for the Treatment of Venous Leg
   Ulcers
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE therapy; negative pressure wound therapy with instillation; single-use
   negative pressure wound; venous leg ulcer; wound bed preparation
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL;
   GROWTH-FACTOR-BETA; CLINICAL-OUTCOMES; INSTILLATION; SYSTEM; FOOT;
   COMPLEX; MANAGEMENT; BLOOD
AB NPWT has probably been the most important addition to wound care in the current century. Despite this fact, its use in the treatment of VLUs remains very limited. This review first examines the documented and potential VLU wound environment changes that can be facilitated by NPWT. The data supporting the use of NPWT for VLU wound bed preparation, the management of fluid drainage, and the bolstering of skin grafts are evaluated. The similarities and differences between suNPWT, traditional NPWT, and NPWTi are outlined. Included in this review is when and where each therapy may have a place in the treatment of VLUs. Finally, a brief algorithm to enhance the use of NPWT in the treatment of VLUs is presented.
C1 [Horn, Callie; Lantis II, John C.] Mt Sinai West & Icahn Sch Med, New York, NY USA.
   [Fierro, Allegra] Mt Sinai West, New York, NY USA.
   [Lantis II, John C.] Mt Sinai West Hosp, Dept Surg, 425 West 59th St, New York, NY 10019 USA.
C3 Mount Sinai West; Mount Sinai West; Mount Sinai West
RP Lantis, JC II (通讯作者)，Mt Sinai West Hosp, Dept Surg, 425 West 59th St, New York, NY 10019 USA.
EM John.Lantis@mountsinai.org
OI Horn, Callie/0000-0001-8609-2716
CR Alhajj M., 2022, Statpearls
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NR 73
TC 4
Z9 5
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2023
VL 35
IS 6
BP 117
EP +
DI 10.25270/wnds/23035
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA Q4LJ5
UT WOS:001057247200001
PM 37276542
DA 2026-07-24
ER
PT J
AU Zhang, H
   Zhou, M
   Wang, Y
   Zhang, D
   Qi, BW
   Yu, AX
AF Zhang, Hao
   Zhou, Min
   Wang, Yu
   Zhang, Dong
   Qi, Baiwen
   Yu, Aixi
TI Role of Autologous Fat Transplantation Combined with Negative-Pressure
   Wound Therapy in Treating Rat Diabetic Wounds
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID STEM-CELLS; METAANALYSIS; MACROPHAGES; PHENOTYPE
AB Background:Negative-pressure wound therapy (NPWT) and autologous fat transplantation (AFT) are two clinical modalities for plastic and reconstructive surgery. At present, there are few reports on the combination of these two methods in treating diabetic wounds. This study aimed to explore the effect of this combined therapy on diabetic wound healing.Methods:Full-thickness dorsal cutaneous wounds in rats with streptozotocin-induced diabetes were treated with either NPWT, AFT, or combined therapy. Rats covered with commercial dressings served as the control group. Macroscopic healing kinetics were examined. The levels of inflammation-related factors, such as interleukin-1 & beta; (IL-1 & beta;), interleukin-6 (IL-6), monocyte chemoattractant protein-1, arginase-1, and inducible nitric oxide synthase (iNOS) and angiogenesis-related factors such as vascular endothelial growth factor, were measured in the wound tissues on days 3, 7, and 14; immunohistochemical staining for arginase-1, iNOS, and CD31 was performed on days 3, 7, and 14. The length of reepithelialization was investigated on day 14.Results:The combined therapy promoted faster wound healing than the other treatments. The expression levels of the proinflammatory factors IL-1 & beta;, IL-6, monocyte chemoattractant protein-1 (MCP-1), and iNOS were reduced, and arginase-1 expression was increased compared with those in the other groups. The expression levels of vascular endothelial growth factor and CD31 in the NPWT-combined-with-AFT group were significantly higher than those in the other groups. Reepithelialization was faster in the NPWT-combined-with-AFT group (by day 14) than in the other groups.Conclusion:Combining NPWT and AFT can enhance diabetic wound healing by improving wound inflammation and increasing wound vascularization.Clinical Relevance Statement:The authors designed a randomized controlled trial of diabetic rats to confirm that NPWT can enhance the vascularization and improve inflammation of the diabetic wound after the autologous fat transplantation treatment. This article may provide a new idea for treating diabetic wounds.
C1 [Zhang, Hao; Zhou, Min; Wang, Yu; Zhang, Dong; Qi, Baiwen; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan, Peoples R China.
   [Qi, Baiwen; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430072, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Qi, BW; Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430072, Hubei, Peoples R China.
EM wb002162@whu.edu.cn; yuaixi@whu.edu.cn
FU Zhongnan Hospital of Wuhan University and Joint Fund Project of Health
   Commission of Hubei Province [WJ2019H067]; Natural Science Foundation of
   Hubei Province [2020CFB662]; Health Commission of Hubei Province Medical
   Leading Talent Project [LJ20200405]
FX This study was supported by Zhongnan Hospital of Wuhan University and
   Joint Fund Project of Health Commission of Hubei Province (grant
   WJ2019H067), the Natural Science Foundation of Hubei Province (grant
   2020CFB662), and the Health Commission of Hubei Province Medical Leading
   Talent Project (grant LJ20200405).
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NR 37
TC 5
Z9 5
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2023
VL 152
IS 3
BP 561
EP 570
DI 10.1097/PRS.0000000000010226
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA Q6XM5
UT WOS:001058934500038
PM 36727776
DA 2026-07-24
ER
PT J
AU Bekeny, JC
   Huffman, SS
   Thomas, C
   Tumminello, M
   Kata, A
   Parikh, R
   Tom, LK
   Kleiber, GM
AF Bekeny, Jenna C.
   Huffman, Samuel S.
   Thomas, Chris
   Tumminello, Mariana
   Kata, Anna
   Parikh, Rajiv
   Tom, Laura K.
   Kleiber, Grant M.
TI Small Intestinal Perforation after 360-Degree Liposuction: A Case Report
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Liposuction; Lipectomy; Intestinal perforation; Abdominal injuries;
   Complications
ID BOWEL PERFORATION; NECROTIZING FASCIITIS; ABDOMINAL LIPOSUCTION; SUCTION
   LIPOPLASTY; COMPLICATIONS; PERITONITIS; SURGERY; SAFETY
AB ObjectiveAs one of the most commonly performed cosmetic procedures, liposuction is relatively safe. Bowel injury following liposuction is a rare but devastating complication, which necessitates hospital admission and surgical intervention. The authors highlight a case report describing the presentation, diagnosis, and management of a patient with bowel injury following liposuction.CaseA 58-year-old woman presented with abdominal pain, erythema, and discharge three days after 360-degree abdominal liposuction with concomitant fat grafting to bilateral buttocks at an outpatient surgery center. Bowel perforation was suspected after CT-scan revealed extraluminal gas in the abdomen and communication that traversed the peritoneum. Exploratory laparotomy was performed which demonstrated at least one site of distinct perforation of the small bowel and an area omentum noted to be inflamed, thickened and with a purulent rind. The patient underwent 20-cm small bowel resection and partial omentectomy temporarily closed with negative pressure wound therapy. After subsequent abdominal wall debridements the patient received ventral hernia repair with bridging mesh and abdominal closure.ConclusionsWhile safe, elective cosmetic procedures are not without risk of serious and even fatal complications. Providers must be familiar with the presentation of bowel injury following abdominal liposuction to prevent delays in appropriate surgical and medical care.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266
C1 [Bekeny, Jenna C.; Huffman, Samuel S.; Parikh, Rajiv; Tom, Laura K.; Kleiber, Grant M.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, 3800 Reservoir Rd, Washington, DC 20007 USA.
   [Huffman, Samuel S.; Thomas, Chris] Georgetown Univ, Sch Med, Washington, DC USA.
   [Tumminello, Mariana; Kata, Anna] MedStar Georgetown Univ Hosp, Dept Gen Surg, Washington, DC USA.
C3 Georgetown University; Georgetown University; Georgetown University
RP Kleiber, GM (通讯作者)，MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, 3800 Reservoir Rd, Washington, DC 20007 USA.
EM grant.m.kleiber@medstar.net
RI Tom, Laura/OPN-7036-2025; Kleiber, Grant/IQV-6852-2023
OI Huffman, Samuel/0000-0002-1779-8384
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NR 26
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD MAR
PY 2024
VL 48
IS 5
BP 946
EP 952
DI 10.1007/s00266-023-03567-w
EA AUG 2023
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA MS1F8
UT WOS:001065125900004
PM 37653177
DA 2026-07-24
ER
PT J
AU Kanzler, C
   Maehlmann, K
   Lischer, CJ
AF Kanzler, Carolin
   Maehlmann, Kathrin
   Lischer, Christoph J.
TI Application of preventive negative pressure therapy on midline
   laparotomy incisions in horses - a retrospective study
SO PFERDEHEILKUNDE
LA German
DT Article
DE laparatomy; incision; surgical site infection (SSI); horse; ciNPT
ID SURGICAL SITE INFECTION; LONG-TERM SURVIVAL; ABDOMINAL-WALL
   RECONSTRUCTION; VACUUM-ASSISTED CLOSURE; WOUND THERAPY; COMPLICATION
   RATES; COLIC SURGERY; EXPLORATORY CELIOTOMY; RISK-FACTORS; PART 1
AB Negative pressure therapy on wounds (negative pressure wound therapy, NPWT) and surgical incisions (closed incision negative pressure therapy, ciNPT) have been identified as a beneficial factor for wound healing and the reduction of wound healing disorders in humans. Veterinary publications on negative pressure therapy have been focused on wound treatment rather than preventive use. The aim of this study was to evaluate the preventive use of negative pressure therapy on surgical incisions in horses (closed incision negative pressure therapy, ciNPT). In addition, factors effecting the short and long-term outcome of wound healing of midline incisions as well as return to athletic use after convalescence were evaluated. A population of 201 horses were included in this study. The surgical incisions of 57 horses were treated using sterile vacuum wound covers (Incision Management System, KCI Medizinprodukte GmbH, Wiesbaden). The control group consisted of 144 horses with surgical incisions treated with standard wound covers (dry, non-adhesive wound dressing). Factors such as breed, gender, age, weight, vital and laboratory parameters, intraoperative diagnosis, number of laparotomies performed, duration of surgery and anesthesia time and wound healing disorders were associated to outcome. Outcome parameters, including wound infection after the hospitalization, abdominal hernia, colic after convalescence, postoperative use and level of performance were collected from owners via standardized telephone questionnaire. No significant difference was found between laparotomy incisions treated with ciNPT compared to standard wound dressings. Significant effects were found between wound infection and heart rate on arrival in the clinic, internal body temperature on day 5 and 10 after surgery, white blood cell count on day 5 after surgery, diagnosis, duration of surgery and general anesthesia time. Horses with small intestinal disease in combination with colonic enterotomy and horses that required repeated laparotomy had a significantly higher risk of developing an abdominal hernia, compared to the rest of this population. Closed incision negative pressure therapy cannot be recommended for the reduction of wound healing disorders after midline laparotomy in horses.
C1 [Kanzler, Carolin; Maehlmann, Kathrin; Lischer, Christoph J.] Free Univ Berlin, Klin Pferde, Berlin, Germany.
C3 Free University of Berlin
RP Kanzler, C (通讯作者)，Bohlaustr 7, D-99423 Weimar, Germany.
EM carolinkanzler2701@gmail.com
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NR 71
TC 0
Z9 0
U1 0
U2 5
PU HIPPIATRIKA VERLAG MBH
PI STUTTGART
PA POSTFACH 102251, 70018 STUTTGART, GERMANY
SN 0177-7726
J9 PFERDEHEILKUNDE
JI Pferdeheilkunde
PD JUL-AUG
PY 2023
VL 39
IS 4
BP 332
EP 346
DI 10.21836/PEM20230404
PG 15
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA R7BV5
UT WOS:001065878600004
OA gold
DA 2026-07-24
ER
PT J
AU Rajabaleyan, P
   Jensen, RO
   Moeller, S
   Qvist, N
   Ellebaek, MB
AF Rajabaleyan, Pooya
   Jensen, Rie Overgaard
   Moeller, Soeren
   Qvist, Niels
   Ellebaek, Mark Bremholm
TI Primary anastomosis and suturing combined with vacuum-assisted abdominal
   closure in patients with secondary peritonitis due to perforation of the
   small intestine: a retrospective study
SO BMC SURGERY
LA English
DT Article
DE Secondary peritonitis; Vacuum-assisted closure; Anastomotic leakage;
   Enteroatmospheric fistula; Open abdomen
ID PRESSURE WOUND THERAPY; OPEN ABDOMEN; NEGATIVE-PRESSURE; SEPSIS;
   MANAGEMENT; FISTULA
AB Background Intestinal resection and a proximal stoma is the preferred surgical approach in patients with severe secondary peritonitis due to perforation of the small intestine. However, proximal stomas may result in significant nutritional problems and long-term parenteral nutrition. This study aimed to assess whether primary anastomosis or suturing of small intestine perforation is feasible and safe using the open abdomen principle with vacuum-assisted abdominal closure (VAC).Methods Between January 2005 and June 2018, we performed a retrospective chart review of 20 patients (> 18 years) with diffuse faecal peritonitis caused by small intestinal perforation and treated with primary anastomosis/suturing and subsequent open abdomen with VAC.Results The median age was 65 years (range: 23-90 years). Twelve patients were female (60%). Simple suturing of the small intestinal perforation was performed in three cases and intestinal resection with primary anastomosis in 17 cases. Four patients (20%) died within 90-days postoperatively. Leakage occurred in five cases (25%), and three patients developed an enteroatmospheric fistula (15%). Thirteen of 16 patients (83%) who survived were discharged without a stoma. The rest had a permanent stoma.Conclusions Primary suturing or resection with anastomosis and open abdomen with VAC in small intestinal perforation with severe faecal peritonitis is associated with a high rate of leakage and enteroatmospheric fistula formation.
C1 [Rajabaleyan, Pooya; Jensen, Rie Overgaard; Qvist, Niels; Ellebaek, Mark Bremholm] Odense Univ Hosp, Univ Southern Denmark, Res Unit Surg, Odense, Denmark.
   [Moeller, Soeren] Univ Southern Denmark, Odense Univ Hosp, Dept Clin Res, OPEN,Open Patient data Explorat Network, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital
RP Rajabaleyan, P (通讯作者)，Odense Univ Hosp, Univ Southern Denmark, Res Unit Surg, Odense, Denmark.
EM Pooya.rajabaleyan@rsyd.dk
RI ; Möller, Sören/X-8738-2019
OI Ellebaek, Mark Bremholm/0000-0001-6550-7505; Rajabaleyan,
   Pooya/0000-0002-6882-9427; Möller, Sören/0000-0003-0858-4269
FU Not applicable.
FX Not applicable.
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NR 37
TC 4
Z9 6
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD SEP 15
PY 2023
VL 23
IS 1
AR 280
DI 10.1186/s12893-023-02179-0
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA R9OX7
UT WOS:001067583800002
PM 37715227
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ding, JR
   Zhu, YQ
   Ge, HQ
   Chen, H
   Wang, LM
   Xie, SX
   Zhang, SW
   Deng, YM
   Yang, R
   Guo, HQ
AF Ding, Jiarong
   Zhu, Yiqi
   Ge, Huaqiang
   Chen, Hui
   Wang, Liangmei
   Xie, Shangxun
   Zhang, Shiwei
   Deng, Yongming
   Yang, Rong
   Guo, Hongqian
TI Negative Pressure Wound Therapy for Patients With Complicated
   Mucocutaneous Separation Following Ileal Conduit Urinary Diversion
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Case series; Ileal conduit; Mucocutaneous separation; Negative pressure
   wound therapy
ID MANAGEMENT
AB BACKGROUND:Mucocutaneous separation (MCS) is one of the early stomal complications of ileal conduit diversion after radical cystectomy. It can result in abdominal infection and sepsis, prolonging patient recovery. Negative pressure wound therapy (NPWT) has been widely used for abdominal wounds after orthopedic and burn surgery. This case series describes its use in complicated MCS and ostomy retraction after ileal conduit diversion.CASES:We describe a case series of 3 patients with moderate to severe MCS with and without infection after robot-assisted radical cystectomy with ileal conduit diversion. Our patients were treated with NPWT to avoid infection and create a satisfactory environment for healing MCS. After 2 to 4 weeks of NPWT, all 3 patients had normal micturition function with no additional peristomal wounds or complications.CONCLUSION:Negative pressure wound therapy may be used in the management of complicated MCS after ileal conduit diversion.
C1 [Ding, Jiarong; Yang, Rong; Guo, Hongqian] Nanjing Univ Chinese Med, Nanjing Drum Tower Hosp, Clin Coll, Dept Urol, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China.
   [Zhu, Yiqi; Chen, Hui; Wang, Liangmei; Zhang, Shiwei; Deng, Yongming] Nanjing Univ Med Sch, Nanjing Drum Tower Hosp, Dept Urol, Affiliated Hosp, Nanjing, Jiangsu, Peoples R China.
   [Ge, Huaqiang] Nanjing Univ Med Sch, Nanjing Drum Tower Hosp, Dept Burn & Plast Surg, Affiliated Hosp, Nanjing, Jiangsu, Peoples R China.
   [Xie, Shangxun] Wenzhou Med Univ, Affiliated Hosp 2, Dept Urol, Wenzhou, Zhejiang, Peoples R China.
   [Xie, Shangxun] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China.
C3 Nanjing University; Nanjing University of Chinese Medicine; Nanjing
   University; Nanjing University; Wenzhou Medical University; Wenzhou
   Medical University
RP Yang, R; Guo, HQ (通讯作者)，Nanjing Univ Chinese Med, Nanjing Drum Tower Hosp, Clin Coll, Dept Urol, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China.
EM gydjiarong@126.com; 354599496@qq.com; 845162074@qq.com;
   845162074@qq.com; 13770835727@163.com; sipangxie@yeah.net;
   zsw999@hotmail.com; dr.dym@foxmail.com; doctoryr@gmail.com;
   dr.ghq@nju.edu.cn
FU National Natural Science Foundation of China [82172691, 81772727,
   81972388, 81772710]; Nanjing Health Science and Technology Development
   Fund [ZKX19011]
FX The authors thank Hui Chen, BSN, ET, who provided guidance and
   assistance during the management of the three complex stomas discussed
   in this paper.r This study was supported by the National Natural Science
   Foundation of China (82172691, 81772727, 81972388, and 81772710) and
   Nanjing Health Science and Technology Development Fund (ZKX19011).
CR Bayci A, 2018, J WOUND OSTOMY CONT, V45, P468, DOI 10.1097/WON.0000000000000471
   Berti-Hearn Linda, 2019, Home Healthc Now, V37, P248, DOI [10.1097/nhh.0000000000000792, 10.1097/NHH.0000000000000792]
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   Carlsson E, 2016, OSTOMY WOUND MANAG, V62, P34
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   Zhou HY, 2019, J WOUND OSTOMY CONT, V46, P413, DOI 10.1097/WON.0000000000000574
NR 14
TC 0
Z9 1
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2023
VL 50
IS 5
BP 420
EP 426
DI 10.1097/WON.0000000000001000
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA S0DP8
UT WOS:001067966400015
PM 37713355
DA 2026-07-24
ER
PT J
AU Hu, J
   Yan, JW
   Su, YX
AF Hu, Jie
   Yan, Jingwen
   Su, Yuxi
TI Mini approaches fasciotomy combined with vacuum sealing drainage for
   acute compartment syndrome caused by fractures in children
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
DE Fasciotomy; Acute compartment syndrome; Mini approaches; Orthopedic;
   Vacuum sealing drainage
ID LEG; DIAGNOSIS
AB PurposeAcute compartment syndrome (ACS) is an urgent, critical condition that requires immediate fasciotomy once diagnosed. Traditionally, fasciotomy of the forearms and lower leg involves one or two long approaches. Our previous study demonstrated that mini approaches fasciotomy was an effective method to treat ACS. This study is aimed at further evaluating the limb functions and complications of mini approaches combined with vacuum sealing drainage (VSD) for treating ACS caused by fractures in the forearms and lower legs.MethodsThis was a retrospective cross-sectional study, and after applying the inclusion and exclusion criteria, we reviewed 126 children who underwent mini treatment approaches for ACS from Jan 2008 to Jan 2022. The selected patients were divided into two groups: group A (ACS group; 58 patients aged 7.77 & PLUSMN;3.45 years) and group B (ACS combined with VSD; 68 patients aged 7.17 & PLUSMN;3.55 years). Patients' clinical data were collected. The patients were followed up, and muscle function in the forearms and lower legs was evaluated.ResultsThe overall incidence of lower legs and forearms ACS was 126/29642 (0.425%). The most common mechanisms of injury were fractures of the forearm (39/74, 52.7%), supracondylar humerus (31/74 41.9%), and elbow (4/74, 5.4%), while those for the lower legs were fractures of the proximal tibia (19/52, 36.5%), midshaft of tibia (25/52, 48.1%), and distal tibia (7/52, 13.5%). According to Flynn's assessment, no significant difference was observed between the two groups (p=0.151). However, the two groups showed significant differences in the hospitalization time (p=0.002) and incision infection rate (0.043).ConclusionsMini approaches fasciotomy combined with VSD is an effective and safe method to treat ACS of the forearms and lower legs caused by fractures in children. This method involves a single-stage surgery and is associated with shorter hospitalization time and incision infection.
C1 [Hu, Jie; Yan, Jingwen; Su, Yuxi] Chongqing Med Univ, Orthoped Dept, Childrens Hosp, Chongqing, Peoples R China.
   [Hu, Jie; Yan, Jingwen; Su, Yuxi] Chongqing Key Lab Pediat, Chongqing, Peoples R China.
   [Hu, Jie; Yan, Jingwen; Su, Yuxi] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China.
   [Hu, Jie; Yan, Jingwen; Su, Yuxi] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China.
   [Hu, Jie; Yan, Jingwen; Su, Yuxi] China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China.
   [Hu, Jie; Yan, Jingwen; Su, Yuxi] Chongqing Med Univ, Jiangxi Hosp, Affiliated Childrens Hosp, Nanchang, Peoples R China.
   [Hu, Jie] Chengdu Womens & Childrens Cent Hosp, Orthoped Dept, Chengdu, Sichuan, Peoples R China.
   [Yan, Jingwen] Cent South Univ, Dept Clin Med, Xiangya Sch Med, Changsha, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Central
   South University
RP Su, YX (通讯作者)，Chongqing Med Univ, Orthoped Dept, Childrens Hosp, Chongqing, Peoples R China.; Su, YX (通讯作者)，Chongqing Key Lab Pediat, Chongqing, Peoples R China.; Su, YX (通讯作者)，Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China.; Su, YX (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China.; Su, YX (通讯作者)，China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China.; Su, YX (通讯作者)，Chongqing Med Univ, Jiangxi Hosp, Affiliated Childrens Hosp, Nanchang, Peoples R China.
EM 981341831@qq.com; 2737572854@qq.com; suyuxi@hospital.cqmu.edu.cn
RI Su, Yuxi/KEI-4480-2024
OI Su, Yuxi/0000-0003-1904-5594
FU Thanks are due to Hanjun Wu in our Medical Record Department for data
   collection and all staffs in Orthopedic Department performing the
   surgeries.
FX Thanks are due to Hanjun Wu in our Medical Record Department for data
   collection and all staffs in Orthopedic Department performing the
   surgeries.
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NR 21
TC 2
Z9 2
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD JUN
PY 2024
VL 48
IS 6
SI SI
BP 1481
EP 1487
DI 10.1007/s00264-023-05984-7
EA SEP 2023
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA PQ8Z5
UT WOS:001068133300001
PM 37733064
DA 2026-07-24
ER
PT J
AU Goldman, T
   Costa, B
AF Goldman, Theodore
   Costa, Ben
TI A Systematic Review and Meta-analysis of Two Negative Pressure Wound
   Therapy Devices to Manage Cesarean Section Incisions
SO AMERICAN JOURNAL OF PERINATOLOGY
LA English
DT Review
DE surgical site infection; obesity; cesarean section; negative pressure
   wound therapy; meta-analysis; systematic review
ID SURGICAL-SITE INFECTION; OBESE WOMEN; SKIN INCISION; RISK-FACTORS;
   DELIVERY; COMPLICATIONS; PREVENTION; PREGNANCY; IMPACT; COSTS
AB This paper aims to evaluate whether there is a device-dependent effect on the reduction of surgical site complications in obese patients (body mass index [BMI] >= 30 kg/m(2)) undergoing cesarean section ( C-section). PubMed, Embase, Cochrane Library, and ClinicalTrials.gov were searched for the period, January 2011 to September 2021. English language articles describing a randomized controlled trial (RCT) that compared either a -80 or -125mm Hg single-use negative pressure wound therapy ( sNPWT) device to standard dressings in obese (BMI >= 30 kg/m(2)) patients undergoing C- section were included. Conference abstracts and "terminated" RCTs with published results were deemed eligible for inclusion. The primary outcome of interest was surgical site infection (SSI), classified as composite, superficial, or deep. Secondary outcomes assessed included seroma, dehiscence, hematoma, bleeding, reoperation, readmission, blistering, and (composite) wound complications. A total of 223 titles were identified, of which 129 were screened by full- text review. Eleven RCTs encompassing 5,847 patients met the inclusion criteria and were considered eligible for further analysis (-80mm Hg: six studies; -125mm Hg: five studies). A statistically significant improvement in the composite SSI (odds ratio [OR]: 0.69; 95% confidence interval [CI]: 0.54-0.89) and superficial SSI (OR: 0.66; 95% CI: 0.50-0.86) outcomes was observed with the -80mm Hg device, compared with standard dressings. The same effect on SSI outcomes was not observed with the -125mm Hg device ( composite SSI-OR: 0.91; 95% CI: 0.64- 1.28; superficial SSI-OR: 1.12; 95% CI: 0.70-1.78). There were no statistically significant differences in any of the other assessed outcomes. sNPWT devices may differ in their ability to reduce composite or superficial SSI after C-section.
C1 [Goldman, Theodore] Northwell Hlth, Obstet & Gynecol, Huntington, NY USA.
   [Costa, Ben] Smith??Nephew, Global Clin & Med Affairs, Kingston Upon Hull, England.
   [Costa, Ben] Smith Nephew, Global Clin & Med Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, England.
C3 Northwell Health; Smith & Nephew; Smith & Nephew
RP Costa, B (通讯作者)，Smith Nephew, Global Clin & Med Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, England.
EM ben.costa@smith-nephew.com
OI Costa, Benedict/0000-0002-7132-2520
FU Smith amp; Nephew, Inc.
FX This study was funded by Smith & Nephew, Inc.
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NR 59
TC 4
Z9 7
U1 2
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0735-1631
EI 1098-8785
J9 AM J PERINAT
JI Am. J. Perinatol.
PD MAY
PY 2024
VL 41
SU 01
BP e2786
EP e2798
DI 10.1055/s-0043-1775562
EA SEP 2023
PG 13
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA UL4O5
UT WOS:001069583000005
PM 37726017
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Castro, FJC
   Eguía, AP
   Muñoz-Cruzado, VD
   Aguilar, LT
   González, JT
   Laga, I
   de Juan, FD
   Ciuro, FP
   Ruiz, JP
AF Castro, Francisco Jose Calero
   Eguia, Andres Padillo
   Munoz-Cruzado, Virginia Duran
   Aguilar, Luis Tallon
   Gonzalez, Jose Tinoco
   Laga, Iman
   de Juan, Fernando de la Portilla
   Ciuro, Felipe Pareja
   Ruiz, Javier Padillo
TI Personalized additive manufacturing of devices for the management of
   enteroatmospheric fistulas
SO BIOENGINEERING & TRANSLATIONAL MEDICINE
LA English
DT Article
DE 3D printing; computer-aided design; digestive system fistula;
   personalized medicine; wound care; wound healing
ID PRESSURE WOUND THERAPY; OPEN ABDOMEN; BIOCOMPATIBILITY; SCAFFOLDS
AB Additive manufacturing techniques allow the customized design of medical devices according to the patient's requirements. Enteroatmospheric fistula is a pathology that benefits from this personalization due to its extensive clinical variability since the size and morphology of the wound differ extensively among patients. Standard prosthetics do not achieve proper isolation of the wound, leading to a higher risk of infections. Currently, no effective personalized technique to isolate it has been described. In this work, we present the workflow for the design and manufacture of customized devices adapted to the fistula characteristics as it evolves and changes during the treatment with Negative Pressure Wound Therapy (NPWT). For each case, a device was designed with dimensions and morphology depending on each patient's requirements using white light scanning, CAD design, and additive manufacturing. The design and manufacture of the devices were performed in 230.50 min (184.00-304.75). After the placement of the device, the wound was successfully isolated from the intestinal content for 48-72 h. The therapy was applied for 27.71 & PLUSMN; 13.74 days, and the device was redesigned to adapt to the wound when geometrical evolutionary changes occur during the therapy. It was observed a decrease in weekly cures from 23.63 & PLUSMN; 10.54 to 2.69 & PLUSMN; 0.65 (p = 0.001). The fistulose size was reduced longitudinal and transversally by 3.25 & PLUSMN; 2.56 cm and 6.06 & PLUSMN; 3.14 cm, respectively. The wound depth also decreased by 1.94 & PLUSMN; 1.08 cm. In conclusion, customization through additive manufacturing is feasible and offers promising results in the generation of personalized devices for the treatment of enteroatmospheric fistula.
C1 [Castro, Francisco Jose Calero; Munoz-Cruzado, Virginia Duran; Aguilar, Luis Tallon; Gonzalez, Jose Tinoco; Laga, Iman; de Juan, Fernando de la Portilla; Ciuro, Felipe Pareja; Ruiz, Javier Padillo] Univ Seville, Hosp Univ Virgen Rocio, Oncol Surg Cell Therapy & Organ Transplantat Grp, Inst Biomed Sevilla IBiS,CSIC, Seville, Spain.
   [Castro, Francisco Jose Calero; Munoz-Cruzado, Virginia Duran; Aguilar, Luis Tallon; Gonzalez, Jose Tinoco; Laga, Iman; de Juan, Fernando de la Portilla; Ciuro, Felipe Pareja; Ruiz, Javier Padillo] Univ Seville, Hosp Univ Virgen Rocio, IBiS, Dept Gen Surg,CSIC, Seville, Spain.
   [Munoz-Cruzado, Virginia Duran; Aguilar, Luis Tallon; Gonzalez, Jose Tinoco; de Juan, Fernando de la Portilla; Ciuro, Felipe Pareja; Ruiz, Javier Padillo] Univ Seville, Seville, Spain.
   [Munoz-Cruzado, Virginia Duran; Ciuro, Felipe Pareja] Virgen Rocio Univ Hosp, Div Gen Surg, Av Manuel Siurot S-N, Seville 41013, Spain.
C3 Virgen del Rocio University Hospital; Consejo Superior de
   Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE -
   Instituto de Biomedicina de Sevilla (IBIS); Consejo Superior de
   Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE -
   Instituto de Biomedicina de Sevilla (IBIS); Virgen del Rocio University
   Hospital; University of Sevilla; Virgen del Rocio University Hospital
RP Muñoz-Cruzado, VD; Ciuro, FP (通讯作者)，Virgen Rocio Univ Hosp, Div Gen Surg, Av Manuel Siurot S-N, Seville 41013, Spain.
EM virginia.dm.87@gmail.com; felipe.pareja67@gmail.com
RI ; Tallon-Aguilar, Luis/JHV-1215-2023; PAREJA CIURO,
   FELIPE/GZM-1224-2022; de la Portilla, Fernando/ABD-5393-2020; Durán
   Muñoz-Cruzado, Virginia/GYD-4982-2022
OI Laga Boul-Atarass, Imán/0000-0002-4496-3162; Tallon-Aguilar,
   Luis/0000-0002-7549-619X; Calero Castro, Francisco
   José/0000-0002-6039-3091; PAREJA CIURO, FELIPE/0000-0001-9192-3465; 
FU We would like to thank the personnel involved in the difficult care of
   these patients.
FX We would like to thank the personnel involved in the difficult care of
   these patients.
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NR 31
TC 2
Z9 2
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2380-6761
J9 BIOENG TRANSL MED
JI Bioeng. Transl. Med.
PD NOV
PY 2023
VL 8
IS 6
DI 10.1002/btm2.10583
EA SEP 2023
PG 12
WC Biotechnology & Applied Microbiology; Engineering, Biomedical;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering; Pharmacology &
   Pharmacy
GA CG6K6
UT WOS:001070770100001
PM 38023715
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Noh, BG
   Yoon, M
   Park, YM
   Seo, HI
   Kim, S
   Hong, SB
   Park, JK
   Lee, MW
AF Noh, Byeong Gwan
   Yoon, Myunghee
   Park, Young Mok
   Seo, Hyung-Il
   Kim, Suk
   Hong, Seung Baek
   Park, Jae Kyun
   Lee, Moon Won
TI Successful resolution of gastric perforation caused by a severe
   complication of pancreatic walled-off necrosis: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Acute necrotizing pancreatitis; Endoscopy; Vacuum assisted closure;
   Gastric rupture; Surgery; Case report
ID NECROTIZING PANCREATITIS; MANAGEMENT; LEAKS
AB BACKGROUNDPancreatic walled-off necrosis (WON) rarely causes critical gastric necrosis and perforation, which may develop when pancreatic WON squashes against the stomach. The Atlanta 2012 guidelines were introduced for acute pancreatitis and its related clinical entities. However, there are few reported cases describing the clinical course and resolution of pancreatic WON.CASE SUMMARYWe report the case of a 45-year-old man who presented to the urgent emergency department with gastric perforation caused by a severe complication of pancreatic WON on computed tomography. The patient underwent an emergency distal pancreatectomy, splenectomy, and gastric wedge resection. Postoperative findings showed re-perforation of the gastric wall at a previously resected margin. Furthermore, endoscopic examination revealed an ulcerative area with a defect in the fundus. After diagnostic endoscopy, endoscopic vacuum-assisted closure was performed, and continuous suction was transferred over all tissues in contact with the sponge surface. The patient recovered without any further complications and was discharged in good condition at postoperative week 8. No recurrence occurred during the 6-mo follow-up period.CONCLUSIONWhen managing a patient with serious gastric perforation complicated by pancreatic WON, a multidisciplinary treatment approach should be considered.
C1 [Noh, Byeong Gwan; Yoon, Myunghee; Park, Young Mok; Seo, Hyung-Il; Park, Jae Kyun] Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Surg, Pusan 49241, South Korea.
   [Kim, Suk; Hong, Seung Baek] Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Radiol, Pusan 49241, South Korea.
   [Lee, Moon Won] Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Internal Med, Pusan 49241, South Korea.
   [Yoon, Myunghee] Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Surg, 179 Gudeok Ro,Seo Gu, Pusan 49241, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital
RP Yoon, M (通讯作者)，Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Surg, 179 Gudeok Ro,Seo Gu, Pusan 49241, South Korea.
EM ymh@pusan.ac.kr
OI Noh, Byeong Gwan/0000-0002-7764-9516
FU Clinical Research Grant from Pusan National University Hospital in 2023
FX Supported by the Clinical Research Grant from Pusan National University
   Hospital in 2023.
CR Banks PA, 2013, GUT, V62, P102, DOI 10.1136/gutjnl-2012-302779
   Bansal A, 2019, JGH OPEN, V3, P450, DOI 10.1002/jgh3.12185
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NR 13
TC 0
Z9 0
U1 0
U2 2
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD SEP 16
PY 2023
VL 11
IS 26
BP 6298
EP 6303
DI 10.12998/wjcc.v11.i26.6298
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA S4XK4
UT WOS:001071211000033
PM 37731568
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ye, SM
   Jin, N
   Sun, J
   Zhang, LQ
   Zhang, JS
   Jing, JH
AF Ye, Shuming
   Jin, Neng
   Sun, Jian
   Zhang, Liqian
   Zhang, Jisen
   Jing, Juehua
TI Delayed Reconstruction of the Perforator Pedicle Propeller Flap after
   the Induced Membrane Technique for Gustilo IIIB Open Distal Tibial
   Fracture
SO ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
LA English
DT Article; Early Access
ID BONE DEFECTS; SOFT-TISSUE; MASQUELET TECHNIQUE; MANAGEMENT;
   OSTEOMYELITIS; EPIDEMIOLOGY; ILIZAROV; FIXATION; TRAUMA
AB Objective This study aimed to evaluate the safety and efficacy of delayed reconstruction of the perforator pedicle propeller flap after the induced membrane technique in the treatment of Gustilo IIIB open distal tibial fracture, and to evaluate the clinical outcome and complications of two different perforator pedicle propeller flaps.
   Methods Thirty-four patients with Gustilo IIIB open distal tibial fractures treated by the induced membrane technique and delayed reconstruction of two different perforator pedicle propeller flaps from May 2017 to March 2022 were retrospectively analyzed. Patients were divided into two groups according to the different kinds of perforator pedicle propeller flaps covered. The operation required two stages. The Radiographic Union Score for Tibial fractures (RUST) was used to evaluate the healing of the tibial bone defect. The American Orthopaedic Foot and Ankle Society (AOFAS) score was used to evaluate ankle function. The complications associated with the technique were recorded.
   Results The number of serial debridements, excluding those performed during emergency and final operations, was a mean of 2.28 +/- 0.83 in the PAPF group and 2.19 +/- 0.83 in the PTAPF group. The PAPF group had a mean bone defect length of 6.76 +/- 0.69 cm, the median healing time of 13.11 +/- 0.96 months, RUST score 12.68 +/- 1.63, and AOFAS score of 84.12 +/- 6.38. On the other hand the PTAPF group's mean bone defect length was 6.73 +/- 0.95 cm, the median healing time 12.63 +/- 1.46 months, RUST score 13.73 +/- 1.53 and AOFAS score 82.79 +/- 5.49. There were no observed significant differences between the two groups in the number of serial debridements, bone defect length, bone union time, RUST score, or AOFAS score (p > 0.05). Flap size ranged from 9 x 6 cm(2) to 14 x 7 cm(2) in the PAPF group and from 9 x 6 cm(2) to 13 x 7 cm(2) in the PTAPF group. There were no severe complications such as flap-related complications or amputation. The differences in complications in the two groups were not statistically significant.
   Conclusion In cases of severe open tibial fracture, the reconstructive method is important. When delayed reconstruction is inevitable, surgeons should first perform radical debridement, followed by vacuum sealing drainage as a bridging therapy; both PAPF and PTAPF can be considered for definitive soft tissue coverage.
C1 [Ye, Shuming] Anhui Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, Hefei, Peoples R China.
   [Ye, Shuming; Jin, Neng; Sun, Jian; Zhang, Liqian; Zhang, Jisen; Jing, Juehua] Anhui Med Univ, Affiliated Hosp 2, Inst Orthopaed, Res Ctr Translat Med, Hefei, Peoples R China.
   [Jin, Neng; Zhang, Liqian; Zhang, Jisen] Anhui Med Univ, Affiliated Hosp 2, Dept Orthopaed, Hefei, Peoples R China.
   [Sun, Jian; Jing, Juehua] Anhui Med Univ, Affiliated Hosp 2, Dept Orthoped Surg, Hefei, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University; Anhui Medical University
RP Ye, SM (通讯作者)，Anhui Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, Furong Rd 678, Hefei 230601, Peoples R China.
EM yeshumingsuda@163.com
FU Hefei Municipal Natural Science Foundation [2021010]; Natural Science
   Foundation of Anhui Province Universities [KJ2020A0182]; Clinical
   Research Cultivation Project of the Second Affiliated Hospital of Anhui
   Medical University [2020LCYB07]; Research Found of Anhui Institute of
   Translational Medicine [2022zhyx-C55]
FX 2021010 | Hefei Municipal Natural Science Foundation | KJ2020A0182 |
   Natural Science Foundation of Anhui Province Universities | 2020LCYB07 |
   Clinical Research Cultivation Project of the Second Affiliated Hospital
   of Anhui Medical University | 2022zhyx-C55 | Research Found of Anhui
   Institute of Translational Medicine
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   Wang P, 2021, INJURY, V52, P988, DOI 10.1016/j.injury.2020.12.009
   Wang X, 2016, BONE JOINT RES, V5, P101, DOI 10.1302/2046-3758.53.2000487
   Whelan DB, 2010, J TRAUMA, V68, P629, DOI 10.1097/TA.0b013e3181a7c16d
NR 35
TC 2
Z9 4
U1 0
U2 6
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1864-6697
EI 1864-6743
J9 Z ORTHOP UNFALLCHIR
JI Z. Orthop. Unfallchir.
PD 2023 SEP 22
PY 2023
DI 10.1055/a-2151-5175
EA SEP 2023
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA S5IC9
UT WOS:001071492600001
PM 37739012
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hussain, F
   Lenz, R
AF Hussain, Fahad
   Lenz, Robin
TI Coupling Negative Pressure Wound Therapy with Instillation and
   Split-thickness Skin Grafting to Manage a Large Chronic Venous Leg
   Ulcer: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation; wound care; limb
   salvage; venous wound
ID CLOSURE; COST
AB Introduction. Chronic VLUs are quite challenging to heal with many currently available treatment methods. The timing and combination of treatment methods is integral to successful wound healing. Objective. This case combined NPWTi coupled with biofilm killing solution, hydrosurgical debridement to prepare the wound bed, and STSG to achieve epithelialization. To the knowledge of the authors of the present study, no previously published case report has combined these methods for treatment of a chronic VLU. Case Report. This case report highlights a chronic VLU on the anteromedial ankle that healed in 2 months using NPWTi and STSG. Conclusion. The combination of NPWTi, hydrosurgery, and STSG to treat this patient resulted in successful wound healing, greatly reduced time to healing compared with standard of care, and allowed the patient to return to her normal lifestyle.
C1 [Hussain, Fahad; Lenz, Robin] RWJ Barnabas Hlth, Community Med Ctr, Toms River, NJ USA.
   [Lenz, Robin] Ocean Cty Foot & Ankle Surg Assoc, Toms River, NJ USA.
RP Hussain, F (通讯作者)，Dept Foot & Ankle Surg, 99 NJ-37, Toms River, NJ 08753 USA.
EM fahadhussaindpm@gmail.com
CR Faust E, 2021, PLAST RECONSTR SURG, V147, p16S, DOI 10.1097/PRS.0000000000007607
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Liu XC, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000014389
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Ma H, 2014, J VASC SURG-VENOUS L, V2, P355, DOI 10.1016/j.jvsv.2014.04.006
   Milic DJ, 2009, J VASC SURG, V49, P1242, DOI 10.1016/j.jvs.2008.11.069
   Millan SB, 2019, AM FAM PHYSICIAN, V100, P298
   Murray CK, 2011, J TRAUMA, V71, pS235, DOI 10.1097/TA.0b013e318227ac5f
   Phillips PL, 2013, INT WOUND J, V10, P48, DOI 10.1111/iwj.12180
   Raad W, 2010, INT WOUND J, V7, P81, DOI 10.1111/j.1742-481X.2010.00658.x
   Rai Reena, 2014, Indian Dermatol Online J, V5, P408, DOI 10.4103/2229-5178.137830
   Salomé GM, 2014, WORLD J SURG, V38, P233, DOI 10.1007/s00268-013-2228-x
   Weller CD, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1314-4
   Yang CK, 2015, J VASC SURG, V61, P995, DOI 10.1016/j.jvs.2014.11.076
NR 14
TC 4
Z9 4
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2023
VL 35
IS 2
BP E59
EP E62
DI 10.25270/wnds/22037
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5MK7
UT WOS:001071604700002
PM 36897615
DA 2026-07-24
ER
PT J
AU Kim, PJ
   Fernandez, L
   Matthews, M
AF Kim, Paul J.
   Fernandez, Luis
   Matthews, Marc
TI Early Experience and Recommendations for the Use of an Automated
   Estimator of Solution Volume for Negative Pressure Wound Therapy With
   Instillation
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE automation; instillation; negative pressure wound therapy; solution
ID STANDARD
AB Introduction. NPWTi is a device that combines the benefits of traditional NPWT with periodic irrigation. This automated device allows for preprogrammed cycles of dwelling of a solution and negative pressure onto the wound surface. Its adoption has been hampered by the perceived difficulty of estimating the volume of solution needed per dwell cycle. A new software update includes an AESV that makes this determination for the clinician. Objective. This case series of 23 patients presents the observations of 3 experienced users at 3 institutions who employed NPWTi with the AESV. Materials and Methods. The authors subjectively assessed the wounds to determine whether the expected clinical result was achieved utilizing AESV on a variety of anatomical locations and wound types. Results. The AESV demonstrated the ability to reliably estimate adequate solution amount in 65% (15/23) of cases. In wounds greater than 120 cm(3), the AESV underestimated the amount of solution needed. Conclusion. To the authors' knowledge, this is the first publication describing the use of AESV for NPWTi. The benefits and limitations of this software upgrade are reported and recommendations for optimal use are provided.
C1 [Kim, Paul J.] Univ Texas Southwestern Med Ctr Dallas, Plast Surg, Dallas, TX 75390 USA.
   [Fernandez, Luis] Univ Texas Hlth Sci Ctr Tyler, Dept Surg, Div Trauma Surg Surg Crit Care, Tyler, TX USA.
   [Matthews, Marc] Univ Arizona, Coll Med, Dept Surg, Phoenix, AZ USA.
   [Matthews, Marc] Arizona Burn Ctr, Phoenix, AZ USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas-Health Sciences
   Center at Tyler (UTHSCT); University of Arizona
RP Kim, PJ (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, 1801 Inwood Rd, Dallas, TX 75390 USA.
EM Paul.Kim@UTSouthwestern.edu
RI ; Oceja, Luis/B-5599-2011
OI , Paul/0000-0002-6186-6890; 
CR Gabriel A., 2014, Eplasty, V14
   Gabriel A, 2021, PLAST RECONSTR SURG, V147, p68S, DOI 10.1097/PRS.0000000000007614
   Kim PJ, 2022, INT WOUND J, V19, P888, DOI 10.1111/iwj.13689
   Kim PJ, 2020, INT WOUND J, V17, P1194, DOI 10.1111/iwj.13424
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2018, WOUNDS, pS1
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Kim PJ, 2013, PLAST RECONSTR SURG, V132, P1569, DOI 10.1097/PRS.0b013e3182a80586
   Kim PJ, 2015, Wounds, V27, pS2
   Lessing M Christian, 2013, Eplasty, V13, pe51
   McKanna M, 2016, OSTOMY WOUND MANAG, P3
   Phillips PL, 2013, INT WOUND J, V10, P48, DOI 10.1111/iwj.12180
   Timmers MS, 2009, WOUND REPAIR REGEN, V17, P278, DOI 10.1111/j.1524-475X.2009.00458.x
   Yang C, 2017, WOUNDS, V29, P240
NR 14
TC 2
Z9 2
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2023
VL 35
IS 2
BP E82
EP E87
DI 10.25270/wnds/22029
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5MK7
UT WOS:001071604700006
PM 36897619
DA 2026-07-24
ER
PT J
AU Mullins, RF
   Wilson, J
   Hassan, Z
   Homsombath, B
   Craft-Coffman, B
   Paglinawan, R
   Cregan, I
   Fagan, S
AF Mullins, Robert F.
   Wilson, Joan
   Hassan, Zaheed
   Homsombath, Bounthavy
   Craft-Coffman, Beretta
   Paglinawan, Rey
   Cregan, Inez
   Fagan, Shawn
TI The Role of Personal-use Negative Pressure Wound Therapy with Enhanced
   Functionality in Achieving Wound-related Treatment Goals: A Small
   Prospective Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE goals of care; granulation tissue; negative pressure wound therapy;
   patient satisfaction; wound healing
ID DIABETIC FOOT ULCERS; SINGLE-USE; IMPACT; COST
AB Background. NPWT is widely used to manage hard-to-heal wounds, and many different devices are available. Personal-use NPWT systems are becoming more popular, although current options have limited functionality. Purpose. The primary objective was to determine acceptable progress of wounds towards a predefined goal of therapy for a variety of open wounds being treated with a novel NPWT personal-use system with enhanced functionality. Methods. In this prospective, nonrandomized, interventional study, patients were treated with a personal-use NPWT system over 4 weeks, initially in a wound care clinic setting, and were discharged home with the device. Clinician satisfaction with the device was also evaluated. Results. Ten patients were evaluated. Acceptable progress towards all predetermined goals was reached for all patients; a median reduction in wound volume of 84.6% and improved granulation was achieved within the 4-week treatment period. No device-related deficiencies were reported. In general, clinicians were satisfied with the device's ease of use and mobility. Conclusion. Personal-use NPWT is easy to use, has positive effects on healing on a variety of wound types, and is well accepted by clinicians.
C1 [Mullins, Robert F.; Hassan, Zaheed; Homsombath, Bounthavy; Craft-Coffman, Beretta; Fagan, Shawn] Joseph M Still Burn Ctr Burn & Reconstruct Ctr Am, Adv Wound Clin, Augusta, GA USA.
   [Wilson, Joan] Joseph M Still Res Fdn Inc, Augusta, GA USA.
   [Paglinawan, Rey; Cregan, Inez] Medela AG, Baar, Switzerland.
RP Paglinawan, R (通讯作者)，Medela AG, Laettichstr 4b, CH-6340 Baar, Switzerland.
EM rey.paglinawan@medela.com
RI Mullins, Robert/I-6717-2013
FU Medela AG
FX The support of Medela AG as the sponsor for this project is gratefully
   acknowledged.
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Banasiewicz T, 2019, Wounds International, V10, P56
   Bechert K., 2020, Wounds, V32, pS1
   Cuomo R, 2021, J INVEST SURG, V34, P335, DOI 10.1080/08941939.2019.1616009
   Guest JF, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2020-045253
   Huang Q, 2019, J FOOT ANKLE SURG, V58, P954, DOI 10.1053/j.jfas.2018.12.020
   Kirsner R, 2019, WOUND REPAIR REGEN, V27, P519, DOI 10.1111/wrr.12727
   Kirsner RS, 2020, WOUND MANAG PREV, V66, P30, DOI 10.25270/wmp.2020.3.3038
   Lee CK, 2018, S ADV WOUND CAR SPRI
   Lerman B, 2010, PLAST RECONSTR SURG, V126, P1253, DOI 10.1097/PRS.0b013e3181ea4559
   Lerman Bruce, 2010, J Diabetes Sci Technol, V4, P825
   Norman G, 2020, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD009261.pub6, 10.1002/14651858.CD009261.pub5]
   Nussbaum SR, 2018, VALUE HEALTH, V21, P27, DOI 10.1016/j.jval.2017.07.007
   Panayi AC, 2017, World Journal of Dermatology, V6, P1, DOI [10.5314/wjd.v6.i1.1, 10.5314/wjd.v6.i1.1, DOI 10.5314/WJD.V6.I1.1]
   Payne Caroline, 2014, Eplasty, V14, pe20
   Sen CK, 2021, ADV WOUND CARE, V10, P281, DOI 10.1089/wound.2021.0026
   Shiroky J, 2020, SURGERY, V167, P1001, DOI 10.1016/j.surg.2020.01.018
   van den Bulck R, 2013, INT WOUND J, V10, P145, DOI 10.1111/j.1742-481X.2012.00954.x
   Zhang J, 2014, PLAST RECONSTR SURG, V134, P141, DOI 10.1097/PRS.0000000000000275
   Zwanenburg PR, 2020, ANN SURG, V272, P81, DOI 10.1097/SLA.0000000000003644
NR 20
TC 2
Z9 2
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2023
VL 35
IS 3
BP 53
EP 58
DI 10.25270/wnds/22019
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5MO5
UT WOS:001071608500010
PM 36917784
DA 2026-07-24
ER
PT J
AU Desvigne, M
   Montgomery, K
   Holifield, K
   Day, K
   Gilmore, D
   Wardman, AL
AF Desvigne, Michael
   Montgomery, Krista
   Holifield, Kurt
   Day, Kari
   Gilmore, Denise
   Wardman, Ashley L.
TI Rotation Flap Closure of Pressure Injuries Following Negative Pressure
   Wound Therapy With Instillation for Wound Cleansing
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE closed incision negative pressure therapy; negative pressure wound
   therap with instillation and dwell time; pressure injury; pressure
   ulcer; surgical flaps; wound cleansing
ID VACUUM-ASSISTED CLOSURE
AB Introduction. Wound cleansing is integral during early-stage wound management and affords the transition to modalities promoting granulation tissue formation and reepithelialization, or preparation for wound coverage/closure. NPWTi-d includes periodic instillation of topical wound cleansing solutions and negative pressure for infectious material removal. Materials and Methods. This was a retrospective study of 5 patients who were admitted to an acute care hospital and treated for PI. After initial wound debridement, NPWTi-d instilled normal saline or HOCl solution (40 mL-80 mL) onto the wound for a dwell time of 20 minutes followed by 2 hours of subatmospheric pressure (-125 mm Hg). NPWTi-d duration was 3 to 6 days with 48-hour dressing changes. Results. NPWTi-d helped cleanse 10 PIs in 5 patients (age, 39-89 years) with comorbidities to facilitate primary closure using rotation flaps. In 4 patients, rotation flap closures were performed without immediate postoperative complications, followed by hospital discharge within 72 hours. In one patient, closure was preempted due to an unrelated medical issue. A stoma was created to prevent further contamination. The patient returned for flap coverage post colostomy. Conclusion. The findings herein support the use of NPWTi-d in the cleansing of complex wounds and suggest that it may facilitate an expedited transition to rotation flap closure for this wound type.
C1 [Desvigne, Michael; Montgomery, Krista; Holifield, Kurt; Day, Kari; Gilmore, Denise] Valley Wound Care Specialists, Peoria, IL USA.
   [Desvigne, Michael; Wardman, Ashley L.] Desvigne Plast Surg, Scottsdale, AZ USA.
   [Desvigne, Michael; Montgomery, Krista; Holifield, Kurt; Day, Kari; Gilmore, Denise] Abrazo Arrowhead Hosp, Glendale, AZ USA.
RP Desvigne, M (通讯作者)，Valley Wound Care Specialists, Wound Reconstruct, 24654 N Lake Pleasant Pkwy, Peoria, IL 85383 USA.
EM mndesvigne@yahoo.com
CR Bamba R, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001187
   Berlowitz D., 2012, Preventing pressure ulcers in hospital
   Biglari B, 2014, SPINAL CORD, V52, P80, DOI 10.1038/sc.2013.130
   Gabriel Allen, 2014, Eplasty, V14, pe41
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   Kamradt T, 2017, SPINAL CORD, V55, P535, DOI 10.1038/sc.2016.186
   Kim PJ, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9047
   Kim PJ, 2020, INT WOUND J, V17, P1194, DOI 10.1111/iwj.13424
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2018, WOUNDS, pS1
   Kim Paul J, 2015, Surg Technol Int, V26, P51
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
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   Singh D, 2020, PLAST RECONSTR SURG, V145, p839E, DOI 10.1097/PRS.0000000000006652
   Suissa D, 2011, PLAST RECONSTR SURG, V128, p498E, DOI 10.1097/PRS.0b013e31822b675c
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   Wolvos T, 2015, J WOUND CARE, V24, P15, DOI 10.12968/jowc.2015.24.Sup4b.15
NR 21
TC 1
Z9 1
U1 2
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2023
VL 35
IS 4
BP E173
EP E177
DI 10.25270/wnds/20167
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5MQ2
UT WOS:001071610200007
PM 37220254
DA 2026-07-24
ER
PT J
AU Tarricone, A
   Crisologo, A
   Killeen, A
   Gee, A
   De La Mata, K
   Siah, M
   Oz, O
   Krishnan, P
   Lavery, LA
AF Tarricone, Arthur
   Crisologo, Andrew
   Killeen, Amanda
   Gee, Allen
   De La Mata, Karla
   Siah, Michael
   Oz, Orhan
   Krishnan, Prakash
   Lavery, Lawrence A.
TI Pooled Study-level Analysis of Randomized Controlled Trials Analyzing
   the Effect of Negative Pressure Wound Therapy With Irrigation vs
   Traditional Negative Pressure Wound Therapy on Diabetic Foot Outcomes
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE diabetic foot infection; diabetic foot ulcer; negative pressure wound
   therapy; negative pressure wound therapy with irrigation
ID QUALITY-OF-LIFE; ANTISEPTIC SOLUTION; INSTILLATION; AMPUTATION;
   MORTALITY; IMPACT; MULTICENTER; BIOBURDEN; DISEASE; CLOSURE
AB Introduction. The benefits of NPWT-T for the diabetic foot have been established. The addition of regular periodic irrigation with broad-spectrum antiseptic solution has been shown to reduce bioburden and total bacterial colonies; however, debate remains as to the clinical effect on diabetic foot outcomes. Objective. This study investigated the differences between NPWT-T and NPWT-I for treatment of the diabetic foot and the associated clinical outcomes. Methods. PubMed, Medline/Embase, the Cochrane Library, and Web of Science were searched for relevant literature published between January 1, 2002, and March 1, 2022. Keywords included "Negative Pressure Wound Therapy" AND "Instillation" OR "Irrigation." Three studies with a total of 421 patients (NPWT-T [n = 223], NPWT-I [n = 198]) were included in the meta-analysis. Results. No significant differences were observed between NPWT-T and NPWT-I for BWC (OR, 1.049; 95% CI, 0.709-1.552; P =.810), time to wound closure (SMD, -0.039; 95% CI, -0.233-0.154; P =.691), LOS (SMD, 0.065; 95% CI, -0.128-0.259; P =.508), or AEs (OR, 1.092; 95% CI, 0.714-1.670; P =.69). Conclusion. Results of this systematic review and meta-analysis indicate that further RCTs are required to assess the role of NPWT-I in the management of DFU and DFI.
C1 [Tarricone, Arthur] SUNY Downstate Univ Hosp Brooklyn, 450 Clarkson Ave, Brooklyn, NY 11203 USA.
   [Crisologo, Andrew; Killeen, Amanda; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA.
   [Gee, Allen; Krishnan, Prakash] Icahn Sch Med Mt Sinai, New York, NY USA.
   [De La Mata, Karla] Lenox Hill Hosp Northwell Hlth, New York, NY USA.
   [Siah, Michael] Univ Texas Southwestern Med Ctr Dallas, Div Vasc & Endovascular Surg, Dept Surg, Dallas, TX USA.
   [Oz, Orhan] Univ Texas Southwestern Med Ctr Dallas, Dept Radiol, Dallas, TX 75390 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; University of Texas System; University of Texas
   Southwestern Medical Center; Icahn School of Medicine at Mount Sinai;
   Northwell Health; University of Texas System; University of Texas
   Southwestern Medical Center; University of Texas System; University of
   Texas Southwestern Medical Center
RP Tarricone, A (通讯作者)，SUNY Downstate Univ Hosp Brooklyn, 450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM tarria01@outlook.com
RI ; Oz, Orhan/GVT-7264-2022; Tarricone, Arthur/AAN-9955-2021; Crisologo,
   Peter/JZE-5379-2024
OI Lavery, Lawrence/0000-0002-7920-9952; Crisologo,
   Peter/0000-0002-5367-9235
CR [Anonymous], 2021, Diabetes
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   Omar M, 2016, J WOUND CARE, V25, P475, DOI 10.12968/jowc.2016.25.8.475
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Phillips PL, 2013, INT WOUND J, V10, P48, DOI 10.1111/iwj.12180
   Tahir S, 2018, MATERIALS, V11, DOI 10.3390/ma11050811
   Thorud JC, 2016, J FOOT ANKLE SURG, V55, P591, DOI 10.1053/j.jfas.2016.01.012
   Timmers MS, 2009, WOUND REPAIR REGEN, V17, P278, DOI 10.1111/j.1524-475X.2009.00458.x
   Uoya Yuichiro, 2019, Wounds, V31, pE61
   Wukich DK, 2017, INT J LOW EXTR WOUND, V16, P114, DOI 10.1177/1534734617704083
   Yang C, 2017, WOUNDS, V29, P240
   Yao Z, 2021, J INVEST SURG, V34, P791, DOI 10.1080/08941939.2019.1693667
   Zhang PZ, 2017, ANN MED, V49, P106, DOI 10.1080/07853890.2016.1231932
   Ziegler-Graham K, 2008, ARCH PHYS MED REHAB, V89, P422, DOI 10.1016/j.apmr.2007.11.005
NR 46
TC 3
Z9 3
U1 0
U2 21
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2023
VL 35
IS 4
BP 66
EP +
DI 10.25270/wnds/22080
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5MQ2
UT WOS:001071610200008
PM 37023474
DA 2026-07-24
ER
PT J
AU Robertson, T
   Benitez, L
AF Robertson, Tracy
   Benitez, Leonard
TI Reduced Time to Skin Grafting in Chronic Wounds Using an Esterified
   Hyaluronic Acid Matrix and Negative Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID LOW-FREQUENCY ULTRASOUND; ASSISTED CLOSURE VAC; TISSUE; ULCERS;
   NONCONTACT; SCAFFOLD
AB Introduction. The use of NPWT and eHAM can aid in the closure of chronic wounds with exposed bone and tendon. Objective. The authors examined the time to skin grafting and wound closure in 10 patients after treatment with either NPWT with eHAM (group 1, n = 5) or NPWT without eHAM (group 2, n = 5). Results. The average time to closure was similar between group 1 and group 2 (15.2 weeks vs 14.6 weeks) despite a nearly twofold greater initial wound area. However, the rate of wound closure per week was better in group 1 than in group 2 in terms of both area (9.0 cm(2) vs 6.8 cm(2)) and volume (12.3 cm(3) vs 5.4 cm(3)). In addition, the rate of wound closure per week at skin grafting was better in group 1 than group 2 in terms of both area (4.5 cm(2) vs 3.8 cm(2)) and volume (25.9 cm(3) vs 4.1 cm(3)). All patients in group 1 received skin grafts within 2 to 3 weeks after their second eHAM application. Conclusion. The results of this small case series suggest that eHAM has a synergistic effect when used in combination with NPWT for the treatment of chronic wounds with exposed bone and tendon.
C1 [Robertson, Tracy; Benitez, Leonard] McLaren Bay Reg, Bay City, MI USA.
RP Robertson, T (通讯作者)，Adv Total Wound Care, 912 S Euclid Ave, Bay City, MI 48706 USA.
EM trobertson@advancedtotalwoundcare.com
CR Abe Y, 2018, J MED INVESTIG, V65, P96, DOI 10.2152/jmi.65.96
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Braiman-Wiksman L, 2007, TOXICOL PATHOL, V35, P767, DOI 10.1080/01926230701584189
   Caravaggi C, 2003, DIABETES CARE, V26, P2853, DOI 10.2337/diacare.26.10.2853
   Caravaggi C, 2011, WOUNDS, V23, P228
   Castaño O, 2018, ADV DRUG DELIVER REV, V129, P95, DOI 10.1016/j.addr.2018.03.012
   Chen LH, 2018, INT J BIOL MACROMOL, V116, P572, DOI 10.1016/j.ijbiomac.2018.05.068
   Coban YK, 2012, INT J LOW EXTR WOUND, V11, P155, DOI 10.1177/1534734612456396
   Gibbons GW, 2015, OSTOMY WOUND MANAG, V61, P16
   Horch RE, 2008, J CUTAN MED SURG, V12, P223, DOI 10.2310/7750.2008.07073
   Kim JJ, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001211
   Krzyszczyk P, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00419
   Landi A, 2014, J HAND SURG-EUR VOL, V39, P994, DOI 10.1177/1753193414529046
   Lee M, 2016, WOUND REPAIR REGEN, V24, P581, DOI 10.1111/wrr.12428
   MacEwan MR, 2017, CUREUS J MED SCIENCE, V9, DOI 10.7759/cureus.1736
   Medical Advisory Secretariat, 2006, Ont Health Technol Assess Ser, V6, P1
   Motolese A, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/849321
   Nather A, 2010, ANN ACAD MED SINGAP, V39, P353
   Nawaz Z., 2010, SURGERY, V29, P59
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Shaharudin A, 2016, J WOUND CARE, V25, P585, DOI 10.12968/jowc.2016.25.10.585
   Shevchenko RV, 2010, J R SOC INTERFACE, V7, P229, DOI 10.1098/rsif.2009.0403
   Silverstein Glenn, 2006, J Foot Ankle Surg, V45, P28, DOI 10.1053/j.jfas.2005.10.005
   Simman Richard, 2017, J Am Coll Clin Wound Spec, V9, P1, DOI [10.1016/j.jccw.2018.04.002, 10.1016/j.jccw.2018.04.002]
   Simman Richard, 2016, J Am Coll Clin Wound Spec, V8, P10, DOI [10.1016/j.jccw.2018.01.006, 10.1016/j.jccw.2018.01.006]
   Simman Richard, 2018, Eplasty, V18, pe10
   Turner NJ, 2004, BIOMATERIALS, V25, P5955, DOI 10.1016/j.biomaterials.2004.02.002
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   Yao M, 2014, INT WOUND J, V11, P586, DOI 10.1111/iwj.12005
NR 29
TC 2
Z9 2
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2023
VL 35
IS 5
BP 99
EP 107
DI 10.25270/wnds/21081
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5MW6
UT WOS:001071616600009
PM 37163655
DA 2026-07-24
ER
PT J
AU Loney, A
   Diaz-Garcia, RJ
   Murdoch, JM
   Spitzer, M
AF Loney, Amanda
   Diaz-Garcia, Rafael J.
   Murdoch, Julie M.
   Spitzer, Mandy
TI Utilizing International Consensus Panel Recommendations and a Clinical
   Decision Tree to Guide Selection of Negative Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE acute wounds; chronic wounds; economic efficiencies; quality of life;
   traditional negative pressure wound therapy; single-use negative
   pressure wound therapy
ID COST
AB Introduction. A variety of NPWT products have become commercially available in the last 30 years. Utilizing advanced wound therapies appropriately can improve patient outcomes and decrease health care expenditures. Due to the increasing number of available product options, Hurd and colleagues published 10 Consensus Statements and a clinical decision tree to provide guidance on how and when to use NPWT and when to transition between device types. Objective. To demonstrate the applicability of the consensus panel's statements and the clinical decision tree, 2 clinicians in the United States and Canada explored the benefits of applying these recommendations into their routine wound management practice. Materials and Methods. Case studies were collected and reviewed in accordance with the Consensus Statements and clinical decision tree. Results. Case presentations illustrate the application of the consensus panel's guidance through the prescribing of the NPWT products utilized as standard of care within both facilities. Conclusion. Utilizing NPWT devices according to the consensus panel recommendations and the clinical decision tree may assist in optimizing care delivery to patients and address logistical and economic efficiencies.
C1 [Loney, Amanda] Bayshore Home Hlth, Hamilton, ON, Canada.
   [Diaz-Garcia, Rafael J.] Allegheny Hlth Network, Supply Chain & GPO, Pittsburgh, PA USA.
   [Murdoch, Julie M.] Global Clin & Med Affairs Smith & Nephew, Watford, England.
   [Spitzer, Mandy] Global Clin & Med Affairs Smith & Nephew, Ft Worth, TX USA.
C3 Allegheny Health Network
RP Spitzer, M (通讯作者)，Global Clin & Med Affairs Smith & Nephew, 5600 Clearfork Main St, Ft Worth, TX 76109 USA.
EM amanda.spitzer@smith-nephew.com
RI Diaz-Garcia, Rafael/JGD-0932-2023
CR Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
   Carnali M, 2016, ACTA VULNOLOGICA, V14, P24
   Delhougne G, 2018, OSTOMY WOUND MANAG, V64, P26
   Diehm YF, 2021, J PLAST RECONSTR AES, V74, P357, DOI 10.1016/j.bjps.2020.08.041
   Digital C, 2010, Ideas and opportunities for bending the health care cost curve
   Ebohon S, 2020, S ADV WOUND CARE
   Fife C WD, 2010, Today's Wound Clinic, V4
   Hurd T, 2021, WOUNDS, V33, pS1
   Janssen AHJ, 2021, J TISSUE VIABILITY, V30, P250, DOI 10.1016/j.jtv.2021.01.009
   Kaufman HA., 2021, Financial effects of COVID-19: hospital outlook for the remainder of 2021
   Kirsner RS, 2020, WOUNDS, V32, P328
   McIsaac C, 2007, WOUNDS, V19, P299
   Nussbaum SR, 2018, VALUE HEALTH, V21, P27, DOI 10.1016/j.jval.2017.07.007
   Payne Caroline, 2014, Eplasty, V14, pe20
   Smith+Nephew, 2018, Internal Report. EO.AWM.PCS230.001.v2
   Teague L LK., 2012, Registered Nurses' Association of Ontario, P16
   Wei R., StatPearls
NR 17
TC 4
Z9 4
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2023
VL 35
IS 7
BP E209
EP E217
DI 10.25270/wnds/22085
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5NA2
UT WOS:001071620200002
PM 37523737
DA 2026-07-24
ER
PT J
AU Xu, XF
   Zhou, YW
   Huang, Y
   Le, Q
   Lin, LL
   Yu, ZW
AF Xu, Xiaofeng
   Zhou, Yiwen
   Huang, Ying
   Le, Qian
   Lin, Lili
   Yu, Zhuowen
TI Nursing Management of Abdominal Wound Dehiscence of an Infant With
   Severe Undernutrition and Peristomal Moisture-Associated Dermatitis
   After Ileostomy Closure A Case Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Abdominal wound dehiscence; Nutrition; Peristomal moisture-associated
   dermatitis; Stomal closure; Wound healing
ID RISK-FACTORS; SKIN
AB BACKGROUND: Abdominal wound dehiscence (AWD) is a costly postoperative complication; its management is particularly challenging for WOC nurses when it occurs secondary to an ostomy closure.
   CASE: We present a case of AWD secondary to ileostomy closure in Baby Q, a 9-month 19-day-old female infant. A silver wound contact dressing was used on her dehisced wound followed by negative pressure wound therapy and adhesive tape to pull the wound edge together and promote granulation. We used a combination of enteral nutrition, parenteral nutrition, total parenteral nutrition, and total enteral nutrition adjusting the feeding plan stepwise according to her nutritional status.
   CONCLUSIONS: Malnutrition and severe peristomal skin complications may contribute to the risk of AWD in infants undergoing reversal of a temporary ostomy. Assessing and treating nutritional status and peristomal skin is imperative before performing ostomy closure.
C1 [Xu, Xiaofeng; Zhou, Yiwen; Huang, Ying; Le, Qian; Lin, Lili; Yu, Zhuowen] Fudan Univ, Childrens Natl Med Ctr, Dept Gastroenterol, Childrens Hosp, Shanghai, Peoples R China.
C3 Fudan University
RP Yu, ZW (通讯作者)，Fudan Univ, Childrens Hosp, Dept Gastroenterol, Shanghai 201100, Peoples R China.
EM xxf1065@163.com; Zhouyiwenapril@gmail.com; lele-306@163.com;
   57736174@qq.com; yzw100@126.com
RI lin, lili/JKH-7869-2023
CR Ambe PC, 2018, DTSCH ARZTEBL INT, V115, P182, DOI 10.3238/arztebl.2018.0182
   Colwell JC, 2019, J WOUND OSTOMY CONT, V46, P497, DOI 10.1097/WON.0000000000000599
   Colwell JC, 2011, J WOUND OSTOMY CONT, V38, P541, DOI 10.1097/WON.0b013e31822acd95
   Denys A, 2021, HERNIA, V25, P449, DOI 10.1007/s10029-020-02294-4
   Dissemond J, 2021, J DTSCH DERMATOL GES, V19, P815, DOI [10.1111/ddg.14388_g, 10.1111/ddg.14388]
   Duan SX, 2021, ANN MED, V53, P900, DOI 10.1080/07853890.2021.1938661
   Ducey J, 2022, ARCH DIS CHILD-FETAL, V107, P448, DOI 10.1136/archdischild-2021-322040
   Harries RL, 2016, INT WOUND J, V13, P8, DOI 10.1111/iwj.12662
   Jemec GB, 2011, BRIT J DERMATOL, V164, P330, DOI 10.1111/j.1365-2133.2010.10093.x
   McNichol L., 2022, J WOUND OSTOMY CONT, V49, P235, DOI [10.1097/WON.0000000000000873, DOI 10.1097/WON.0000000000000873]
   Nagano M, 2019, J WOUND OSTOMY CONT, V46, P137, DOI 10.1097/WON.0000000000000491
   Ratliff CR, 2021, J WOUND OSTOMY CONT, V48, P219, DOI 10.1097/WON.0000000000000758
   Salvadalena G, 2020, J WOUND OSTOMY CONT, V47, P357, DOI 10.1097/WON.0000000000000666
   Temesgen F, 2021, ETHIOP J HEALTH SCI, V31, P111, DOI 10.4314/ejhs.v31i1.13
   Timmer AS, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-054534
   van Ramshorst GH, 2009, WORLD J SURG, V33, P1509, DOI 10.1007/s00268-009-0058-7
   Waldhausen JHT, 2000, J AM COLL SURGEONS, V190, P688, DOI 10.1016/S1072-7515(00)00284-2
   Werner JM, 2022, FRONT SURG, V9, DOI 10.3389/fsurg.2022.821509
   Yang H, 2021, ADV SKIN WOUND CARE, V34, P309, DOI 10.1097/01.ASW.0000744336.73981.8f
NR 19
TC 2
Z9 3
U1 3
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2023
VL 50
IS 4
BP 331
EP 336
DI 10.1097/WON.0000000000000987
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA S6IQ3
UT WOS:001072183400012
PM 37467414
DA 2026-07-24
ER
PT J
AU Isath, A
   Gregory, V
   Ohira, S
   Levine, A
   Dhand, A
   Laskowski, I
   Mateo, R
   Babu, S
   Spielvogel, D
   Kai, MSS
AF Isath, Ameesh
   Gregory, Vasiliki
   Ohira, Suguru
   Levine, Avi
   Dhand, Abhay
   Laskowski, Igor
   Mateo, Romeo
   Babu, Sateesh
   Spielvogel, David
   Kai, Masashi
TI Groin wound management after decannulation of veno-arterial
   extracorporeal membrane oxygenation in heart transplantation: Role of
   sartorius muscle flap
SO CLINICAL TRANSPLANTATION
LA English
DT Article
DE heart transplant; Sartorius; VA-ECMO; wound complications
ID CANNULATION; OUTCOMES
AB BackgroundThe management of complex groin wounds following VA-ECMO after heart transplant (HT) is uncertain due to limited experience. Sartorius muscle flaps (SMF) have been used in vascular surgery for groin wound complications. However, their use in HT recipients with perioperative VA-ECMO is unclear. This study aims to describe characteristics and outcomes of HT patients with groin complications after arterial decannulation for femoral VA-ECMO.MethodsWe retrospectively reviewed HT patients who underwent peri-transplant femoral VA-ECMO at our institution from April 2011 to February 2023. Patients were categorized into two groups based on the presence of cannulation-related wound complications.ResultsAmong the 34 patients requiring VA-ECMO peri-transplant, 17 (50%) experienced complications at the cannulation site. Baseline characteristics including duration of VA-ECMO support were comparable in both groups. Patients with complications presented mostly with open wounds (41.1%) after a median duration of 22 days post-transplant. Concurrent groin infections were observed in 52.3% of patients, all caused by gram-negative bacteria.Wound complications were managed with 12 (70.6%) undergoing SMF treatment and 5 (31.2%) receiving conventional therapy. Four SMF recipients had preemptive procedures for wound dehiscence, while eight underwent SMF for groin infections. Among the SMF group, 11 patients had favorable outcomes without recurrent complications, except for one patient who developed a groin infection with pseudoaneurysm formation. Conventional therapy with vacuum assisted closure (VAC) and antibiotics were utilized in four patients without infection and one patient with infection. Three patients required additional surgeries with favorable healing of the wound.ResultsAmong the 34 patients requiring VA-ECMO peri-transplant, 17 (50%) experienced complications at the cannulation site. Baseline characteristics including duration of VA-ECMO support were comparable in both groups. Patients with complications presented mostly with open wounds (41.1%) after a median duration of 22 days post-transplant. Concurrent groin infections were observed in 52.3% of patients, all caused by gram-negative bacteria.Wound complications were managed with 12 (70.6%) undergoing SMF treatment and 5 (31.2%) receiving conventional therapy. Four SMF recipients had preemptive procedures for wound dehiscence, while eight underwent SMF for groin infections. Among the SMF group, 11 patients had favorable outcomes without recurrent complications, except for one patient who developed a groin infection with pseudoaneurysm formation. Conventional therapy with vacuum assisted closure (VAC) and antibiotics were utilized in four patients without infection and one patient with infection. Three patients required additional surgeries with favorable healing of the wound.ConclusionComplications related to femoral VA-ECMO are common in HT patients, with infection being the most frequent complication. SMFs can be a useful tool to prevent progression of infection and improve local healing.
C1 [Isath, Ameesh; Levine, Avi] Westchester Med Ctr, Dept Cardiol, Valhalla, NY USA.
   [Gregory, Vasiliki] New York Med Coll, Valhalla, NY USA.
   [Ohira, Suguru; Spielvogel, David] Westchester Med Ctr, Dept Surg, Div Cardiothorac Surg, Valhalla, NY USA.
   [Dhand, Abhay] Westchester Med Ctr, Dept Med, Transplant Infect Dis, Valhalla, NY USA.
   [Laskowski, Igor; Mateo, Romeo; Babu, Sateesh] Westchester Med Ctr, Dept Surg, Div Vasc Surg, Valhalla, NY USA.
   [Kai, Masashi] Beth Israel Deaconess Med Ctr, Div Cardiac Surg, Boston, MA USA.
   [Ohira, Suguru] New York Med Coll, Westchester Med Ctr, Div Cardiothorac Surg, 100 Woods Rd, Valhalla, NY 10595 USA.
C3 Westchester Medical Center; New York Medical College; Westchester
   Medical Center; Westchester Medical Center; Westchester Medical Center;
   Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Westchester Medical Center; New York Medical
   College
RP Ohira, S (通讯作者)，New York Med Coll, Westchester Med Ctr, Div Cardiothorac Surg, 100 Woods Rd, Valhalla, NY 10595 USA.
EM suguru.ohira@wmchealth.org
RI ; Isath, Ameesh/GPK-5434-2022; Ohira, Suguru/AEH-8009-2022
OI Dhand, Abhay/0000-0003-3527-1938; 
CR Castro R, 2020, J CARDIAC SURG, V35, P3585, DOI 10.1111/jocs.15012
   DeRoo SC, 2019, J THORAC CARDIOV SUR, V158, P1576, DOI 10.1016/j.jtcvs.2019.02.065
   Hwang JW, 2016, J VASC SURG, V63, P998, DOI 10.1016/j.jvs.2015.10.067
   Kittleson MM, 2011, J HEART LUNG TRANSPL, V30, P1250, DOI 10.1016/j.healun.2011.05.006
   Mastoris I, 2022, CIRC-HEART FAIL, V15, DOI 10.1161/CIRCHEARTFAILURE.121.008777
   Ohira S, 2023, CLIN TRANSPLANT, V37, DOI 10.1111/ctr.14871
   Ohira S, 2021, JTCVS TECHNIQUES, V5, P62, DOI 10.1016/j.xjtc.2020.10.035
   Pellenc Q, 2020, EUR J CARDIO-THORAC, V58, P371, DOI 10.1093/ejcts/ezaa039
   Price A, 2020, INT WOUND J, V17, P1669, DOI 10.1111/iwj.13449
   Raffa GM, 2019, ANN THORAC SURG, V107, P311, DOI 10.1016/j.athoracsur.2018.05.063
   Salna M, 2018, J VASC SURG, V67, P542, DOI 10.1016/j.jvs.2017.05.127
   Sbitany H, 2010, PLAST RECONSTR SURG, V126, P933, DOI 10.1097/PRS.0b013e3181e604a1
   Shields RK, 2013, AM J TRANSPLANT, V13, P2137, DOI 10.1111/ajt.12292
   Smood B., 2022, J ARTIF ORGANS, V26, P119
   Töpel I, 2011, J VASC SURG, V53, P1014, DOI [10.1016/j.jvs.2010.11.047, 10.1016/j.jvs.2010.10.047]
   Wallace AB, 2022, ANN VASC SURG, V78, P77, DOI 10.1016/j.avsg.2021.05.049
   Williams IM, 2003, EUR J VASC ENDOVASC, V25, P390, DOI 10.1053/ejvs.2002.1890
   Wübbeke LF, 2020, J VASC SURG, V71, P693, DOI 10.1016/j.jvs.2019.07.073
   Yang D, 1998, SURG RADIOL ANAT, V20, P307, DOI 10.1007/BF01630610
   Zuckermann A, 2011, TRANSPL INT, V24, P627, DOI 10.1111/j.1432-2277.2011.01247.x
NR 20
TC 2
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0902-0063
EI 1399-0012
J9 CLIN TRANSPLANT
JI Clin. Transplant.
PD DEC
PY 2023
VL 37
IS 12
DI 10.1111/ctr.15147
EA SEP 2023
PG 7
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA GJ8F2
UT WOS:001072523300001
PM 37755149
OA Bronze
DA 2026-07-24
ER
PT J
AU Huffman, SS
   Berger, LE
   Li, KR
   Spoer, DL
   Gupta, NJ
   Truong, BN
   Akbari, CM
   Evans, KK
AF Huffman, Samuel S.
   Berger, Lauren E.
   Li, Karen
   Spoer, Daisy L.
   Gupta, Nisha J.
   Truong, Brian N.
   Akbari, Cameron M.
   Evans, Karen K.
TI Muscle versus Fascia Free Tissue Transfer for Treatment of Chronic
   Osteomyelitis in the Comorbid Population
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE free tissue transfer; free flaps; limb salvage; chronic osteomyelitis;
   wounds
ID RECONSTRUCTION; MANAGEMENT; OUTCOMES; FLAPS; INFECTIONS
AB Background In patients with chronic lower extremity (LE) wounds, chronic osteomyelitis confers additional complexity to achieving adequate treatment. Previous reviews demonstrate increased rates of osteomyelitis recurrence in patients who receive muscle flaps compared with fasciocutaneous flaps for LE limb salvage; however, these studies were not limited to atraumatic populations who receive exclusively free flaps. Thus, this study compared rates of recurrence in chronic osteomyelitis patients undergoing LE reconstruction with fasciocutaneous versus muscle free flaps.Methods Patients undergoing free tissue transfer (FTT) between July 2011 and July 2021 were retrospectively reviewed. Patients were stratified into fasciocutaneous and muscle free flap groups. Primary outcomes included osteomyelitis recurrence, flap complications, limb salvage, and ambulatory status.Results Forty-eight patients with pathologic diagnosis of chronic osteomyelitis of the wound bed were identified, of which 58.3% received fasciocutaneous ( n = 28) and 41.7% received muscle flaps ( n = 20). The most common comorbidities included diabetes mellitus ( n = 29, 60.4%), peripheral neuropathy ( n = 27, 56.3%) and peripheral vascular disease ( n = 24, 50.0%). Methicillin-resistant or methicillin -sensitive Staphylococcus aureus were the most common pathogen in 18.7% ( n = 9) of procedures. The majority of patients underwent a median of three debridements followed by negative pressure wound therapy prior to receiving FTT. At a median follow-up of 16.6 months, the limb salvage and ambulatory rates were 79.2 ( n = 38) and 83.3% ( n = 40), respectively. The overall rate of microsurgical flap success was 93.8% ( n = 45). Osteomyelitis recurred in 25% of patients ( n = 12) at a median duration of 4.0 months. There were no significant differences in rates of osteomyelitis recurrence, flap complications, limb salvage, ambulation, and mortality. On multivariate analysis, flap composition remained a nonsignificant predictor of osteomyelitis recurrence (odds ratio: 0.975, p = 0.973).Conclusion This study demonstrates that flap composition may not influence recurrence of osteomyelitis following free flap reconstruction of chronic LE wounds, suggesting that optimal flap selection should be based on wound characteristics and patient goals.
C1 [Huffman, Samuel S.; Li, Karen; Spoer, Daisy L.; Gupta, Nisha J.; Truong, Brian N.] Georgetown Univ, Sch Med, Dept Plast & Reconstruct Surg, Washington, DC USA.
   [Huffman, Samuel S.; Berger, Lauren E.; Spoer, Daisy L.; Evans, Karen K.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
   [Berger, Lauren E.] Rutgers Robert Wood Johnson Med Sch, Plast & Reconstruct Surg Div, New Brunswick, NJ USA.
   [Akbari, Cameron M.] MedStar Georgetown Univ Hosp, Dept Vasc Surg, Washington, DC USA.
C3 Georgetown University; Georgetown University; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences; Georgetown University
RP Evans, KK (通讯作者)，MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM karen.k.evans@medstar.net
OI Spoer, Daisy/0000-0002-1735-5006; Berger, Lauren/0000-0002-5747-0009;
   Huffman, Samuel/0000-0002-1779-8384; Li, Karen
   RuiRui/0000-0002-6672-949X
CR [Anonymous], Osteomyelitis
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NR 43
TC 4
Z9 4
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD MAY
PY 2024
VL 40
IS 04
BP 253
EP 261
DI 10.1055/a-2153-2285
EA SEP 2023
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NC8U4
UT WOS:001073309700001
PM 37579781
DA 2026-07-24
ER
PT J
AU Orlov, A
   Ciliberti, M
   Somma, R
   Gefen, A
AF Orlov, Aleksei
   Ciliberti, Marino
   Somma, Rosa
   Gefen, Amit
TI A robotic venous leg ulcer system reveals the benefits of negative
   pressure wound therapy in effective fluid handling
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bioengineering laboratory testing; chronic wounds; compression therapy;
   exudate management; superabsorbent and foam dressings
ID MANAGEMENT; CARE
AB We applied a market-leading, single-use negative pressure wound therapy device to a robotic venous leg ulcer system and compared its fluid handling performance with that of standard of care, superabsorbent and foam dressings and compression therapy. For each tested product, we determined a metrics of retained, residual, evaporated and (potential) leaked fluid shares, for three exudate flow regimes representing different possible clinically relevant scenarios. The single-use negative pressure wound therapy system under investigation emerged as the leading treatment option in the aspects of adequate fluid handling and consistent delivery of therapeutic-level wound-bed pressures. The superabsorbent dressing performed reasonably in fluid handling (resulting in some pooling but no leakage), however, it quickly caused excessive wound-bed pressures due to swelling, after less than a day of simulated use. The foam dressing exhibited the poorest fluid handling performance, that is, pooling in the wound-bed as well as occasional leakage, indicating potential inflammation and peri-wound skin maceration risks under real-world clinical use conditions. These laboratory findings highlight the importance of advanced robotic technology as contemporary means to simulate patient and wound behaviours and inform selection of wound care technologies and products, in ways that are impossible to achieve if relying solely on clinical trials and experience.
C1 [Orlov, Aleksei; Gefen, Amit] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-69978 Tel Aviv, Israel.
   [Ciliberti, Marino; Somma, Rosa] Ctr Aziendale Riparaz Tissutale, Wound Care Ctr, Castellammare Di Stabia, Italy.
C3 Tel Aviv University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-69978 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
OI Gefen, Amit/0000-0002-0223-7218
FU This work was partially supported by the Israeli Ministry of Science and
   Technology (Medical Devices Program Grant no. 3-17421, awarded to
   Professor Amit Gefen in 2020). In addition, Smith amp;amp; Nephew
   Medical Limited (Watford, United Kingdom) provided [3-17421]; Israeli
   Ministry of Science and Technology (Medical Devices Program); Smith
   amp;amp; Nephew Medical Limited (Watford, United Kingdom)
FX This work was partially supported by the Israeli Ministry of Science and
   Technology (Medical Devices Program Grant no. 3-17421, awarded to
   Professor Amit Gefen in 2020). In addition, Smith & Nephew Medical
   Limited (Watford, United Kingdom) provided financial funding for this
   study.
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NR 44
TC 8
Z9 8
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2024
VL 21
IS 2
DI 10.1111/iwj.14426
EA OCT 2023
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA JB7X4
UT WOS:001073711100001
PM 37786996
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kollmann, L
   Reimer, S
   Lock, JF
   Flemming, I
   Widder, A
   May, J
   Krietenstein, L
   Gruber, M
   Meining, A
   Hankir, M
   Germer, CT
   Seyfried, F
AF Kollmann, Lars
   Reimer, Stanislaus
   Lock, Johan Friso
   Flemming, Ilona
   Widder, Anna
   May, Jana
   Krietenstein, Laura
   Gruber, Maximilian
   Meining, Alexander
   Hankir, Mohammed
   Germer, Christoph-Thomas
   Seyfried, Florian
TI Endoscopic vacuum therapy as a first-line treatment option for gastric
   leaks after bariatric surgery: evidence from 10 years of experience
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Article
DE Anastomotic leak; Bariatric surgery; Endoluminal; Vacuum-assisted
   closure; Negative pressure
ID SLEEVE GASTRECTOMY; MANAGEMENT; COMPLICATIONS
AB Background: Gastric (anastomotic or staple-line) leaks after bariatric surgery are rare but potentially life-threatening complications. Endoscopic vacuum therapy (EVT) has evolved as the most promising treatment strategy for leaks associated with upper gastrointestinal surgery.Objective: The aim of this study was to evaluate the efficiency of our gastric leak management protocol in all bariatric patients over a 10-year period. Special emphasis was placed on EVT treatment and its outcome as a primary treatment or as a secondary treatment when other approaches failed.Setting: This study was performed at a tertiary clinic and certified center of reference for bariatric surgery.Methods: In this retrospective single-center cohort study, clinical outcomes of all consecutive patients after bariatric surgery from 2012 to 2021 are reported, with special emphasis placed on gastric leak treatment. The primary endpoint was successful leak closure. Secondary endpoints were overall complications (Clavien-Dindo classification) and length of stay.Results: A total of 1046 patients underwent primary or revisional bariatric surgery, of whom 10 (1.0%) developed a postoperative gastric leak. Additionally, 7 patients were transferred for leak management after external bariatric surgery. Of these, 9 patients underwent primary and 8 patients underwent secondary EVT after futile surgical or endoscopic leak management. The efficacy of EVT was 100%, and there were no deaths. Complications did not differ between primary EVT and secondary treatment of leaks. Length of treatment was 17 days for primary EVT versus 61 days for secondary EVT (P 5 .015).Conclusions: EVT for gastric leaks after bariatric surgery led to rapid source control with a 100% success rate both as primary and secondary treatment. Early detection and primary EVT shortened treatment time and length of stay. This study underlines the potential of EVT as a first-line treatment strategy for gastric leaks after bariatric surgery. (Surg Obes Relat Dis 2023;19:1041-1048.)& COPY; 2023 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
C1 [Kollmann, Lars; Lock, Johan Friso; Flemming, Ilona; Widder, Anna; May, Jana; Krietenstein, Laura; Gruber, Maximilian; Hankir, Mohammed; Germer, Christoph-Thomas; Seyfried, Florian] Univ Hosp Wuerzburg, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Wurzburg, Germany.
   [Reimer, Stanislaus; Meining, Alexander] Univ Hosp Wuerzburg, Dept Gastroenterol, Wurzburg, Germany.
   [Seyfried, Florian] Univ Hosp Wurzburg, Ctr Operat Med ZOM, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Upper Gastrointestinal & Bariatr Surg, Oberdurrbacherstr 6, D-97080 Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg; University of Wurzburg
RP Seyfried, F (通讯作者)，Univ Hosp Wurzburg, Ctr Operat Med ZOM, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Upper Gastrointestinal & Bariatr Surg, Oberdurrbacherstr 6, D-97080 Wurzburg, Germany.
EM Seyfried_F@ukw.de
RI Lock, Johan/AAA-8114-2020
OI Lock, Johan/0000-0002-9007-3937; Meining, Alexander/0009-0001-3773-138X
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NR 31
TC 13
Z9 17
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD SEP
PY 2023
VL 19
IS 9
BP 1041
EP 1048
DI 10.1016/j.soard.2023.02.010
EA AUG 2023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA S9AH5
UT WOS:001074016400001
PM 36948972
DA 2026-07-24
ER
PT J
AU Tatman, LM
   Gajari, V
   Obremskey, WT
AF Tatman, Lauren M.
   Gajari, Vamshi
   Obremskey, William T.
TI Application of Negative Pressure Wound Therapy
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy; vacuum-assisted closure; Morel-Lavallee
AB The video depicts the materials and steps for applying negative pressure wound therapy. The clinical case involves a patient who had sustained a thigh Morel-Lavallee lesion that developed overlying skin necrosis and drainage that was treated with surgical debridement and the application of negative pressure wound therapy.
C1 [Tatman, Lauren M.] Washington Univ St Louis, Dept Orthopaed Surg, St Louis, MO USA.
   [Gajari, Vamshi; Obremskey, William T.] Vanderbilt Univ, Med Ctr, Dept Orthopaed Surg, Nashville, TN USA.
C3 Washington University (WUSTL); Vanderbilt University
RP Tatman, LM (通讯作者)，Washington Univ St Louis, Dept Orthopaed Surg, 660 S Euclid Ave,Campus POB 8233, St Louis, MO 63110 USA.
EM Tatman@wustl.edu; vamshi.gajari24@gmail.com; william.obremskey@vumc.org
RI Tatman, Lauren/ABC-1858-2020; Obremskey, William/HRA-4704-2023
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   Nickerson TP, 2014, J TRAUMA ACUTE CARE, V76, P493, DOI 10.1097/TA.0000000000000111
   Orgill DP, 2009, SURGERY, V146, P40, DOI 10.1016/j.surg.2009.02.002
   Shen C, 2013, ARCH ORTHOP TRAUM SU, V133, P635, DOI 10.1007/s00402-013-1703-z
   White RA, 2005, J ORTHOP TRAUMA, V19, P56, DOI 10.1097/00005131-200501000-00011
   WINTER GD, 1963, NATURE, V197, P91, DOI 10.1038/197091b0
NR 7
TC 1
Z9 2
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD AUG
PY 2021
VL 35
SU 2
BP S32
EP S33
DI 10.1097/BOT.0000000000002183
PG 2
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA VM9SO
UT WOS:001074196600018
PM 34227602
DA 2026-07-24
ER
PT J
AU Kang, SI
   Kim, S
AF Kang, Sung Il
   Kim, Sohyun
TI The effectiveness of negative-pressure wound therapy for wound healing
   after stoma reversal: a randomized control study
SO ANNALS OF SURGICAL TREATMENT AND RESEARCH
LA English
DT Article
DE Colostomy; Ileostomy; Negative-pressure wound therapy
ID SURGICAL SITE INFECTION; PURSESTRING CLOSURE; LAPAROTOMY; TRIAL; RISK
AB Purpose: The purse-string closure (PSC) method is used for skin closure after stoma reversal to reduce surgical site infections (SSIs). However, PSC requires a longer healing period than primary closure. The application of negative-pressure wound therapy (NPWT) may reduce the healing period of many wound types. This study aimed to investigate whether the application of NPWT promotes wound healing after the PSC method for stoma reversal.Methods: This study was a randomized controlled study. Patients who had undergone stoma reversal surgery were randomized to receive NPWT or simple dressing after surgery. The primary outcome was a complete wound-healing period. We also investigated SSI, hospital stay, total cost, and the patient and observer scar assessment scale (POSAS) as secondary outcomes.Results: A total of 36 patients were randomized into 2 groups. The median wound healing period was shorter in the NPWT group than in the control group (17.5 days [range, 11-24 days] vs. 21.5 days [range, 14-41 days], P = 0.006). SSI rate and hospital stay did not differ between the groups. However, the number of dressings was lower in the NPWT group than in the control group (5 [range, 3-7] vs. 17 [range, 10-30], P < 0.001). The total cost for dressing was comparable between the groups. The POSAS was not different between the groups.Conclusion: This study revealed that NPWT application after PSC for stoma reversal site is effective in reducing the wound healing period compared to simple dressing, without increasing SSI and total cost.
C1 [Kang, Sung Il; Kim, Sohyun] Yeungnam Univ, Med Ctr, Dept Orthopaed Surg, Coll Med, Daegu, South Korea.
   [Kang, Sung Il] Yeungnam Univ, Coll Med, Med Ctr, Dept Surg, 170 Hyeonchung Ro, Daegu 42415, South Korea.
C3 Yeungnam University; Yeungnam University
RP Kang, SI (通讯作者)，Yeungnam Univ, Coll Med, Med Ctr, Dept Surg, 170 Hyeonchung Ro, Daegu 42415, South Korea.
EM sungiry@naver.com
OI Kang, Sung Il/0000-0002-4751-5779
FU 2021 Yeungnam University Research Grant program [221A580020]
FX This work was supported by non-profit grants from the 2021 Yeungnam
   University Research Grant program (221A580020).
CR Camacho-Mauries D, 2013, DIS COLON RECTUM, V56, P205, DOI 10.1097/DCR.0b013e31827888f6
   Carrano FM, 2021, BJS OPEN, V5, DOI 10.1093/bjsopen/zrab116
   Draaijers LJ, 2004, PLAST RECONSTR SURG, V113, P1960, DOI 10.1097/01.PRS.0000122207.28773.56
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   Heard C, 2017, J TISSUE VIABILITY, V26, P79, DOI 10.1016/j.jtv.2016.06.001
   HORAN TC, 1992, INFECT CONT HOSP EP, V13, P606
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   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Kim S, 2020, TRIALS, V21, DOI 10.1186/s13063-019-3925-z
   Klink CD, 2013, INT J SURG, V11, P1123, DOI 10.1016/j.ijsu.2013.09.003
   Lee JT, 2014, DIS COLON RECTUM, V57, P1282, DOI 10.1097/DCR.0000000000000209
   Liu ZM, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010318.pub3
   Ma ZJ, 2016, EXP THER MED, V11, P1307, DOI 10.3892/etm.2016.3083
   McCartan DP, 2013, TECH COLOPROCTOL, V17, P345, DOI 10.1007/s10151-012-0970-y
   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
   Obeid N, 2021, INT J COLORECTAL DIS, V36, P161, DOI 10.1007/s00384-020-03749-x
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NR 21
TC 12
Z9 12
U1 1
U2 5
PU KOREAN SURGICAL SOCIETY
PI SEOUL
PA 3304HO, 101 DONG, BROWNSTONE SEOUL, 335, JUNGMIN-DONG, JUNG-GU, SEOUL,
   100-859, SOUTH KOREA
SN 2288-6575
EI 2288-6796
J9 ANN SURG TREAT RES
JI Ann. Surg. Treat. Res.
PD SEP
PY 2023
VL 105
IS 3
BP 126
EP 132
DI 10.4174/astr.2023.105.3.126
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA S9JG8
UT WOS:001074250100002
PM 37693285
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Amin, N
   Homsombath, B
   Rumbaugh, J
   Craft-Coffman, B
   Fagan, SP
   Chowdhry, T
   Wilson, J
   Paglinawan, R
   Lussi, K
   Hassan, Z
AF Amin, Neha
   Homsombath, Bounthavy
   Rumbaugh, John
   Craft-Coffman, Beretta
   Fagan, Shawn P.
   Chowdhry, Tayseer
   Wilson, Joan
   Paglinawan, Rey
   Lussi, Karin
   Hassan, Zaheed
TI Single-Use Negative Pressure Wound Therapy Applied on Various Wound
   Types An Interventional Case Series
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Home healthcare; Negative pressure wound therapy; Single-use negative
   pressure wound therapy device; Wound healing
ID RECOMMENDATIONS
AB PURPOSE: The purpose of this study was to determine whether a single-use negative pressure wound therapy (NPWT) system achieves individualized goals of therapy when used to treat patients with a variety of wound types.
   DESIGN: Multiple case series.
   SUBJECTS AND SETTING: The same comprised 25 participants; their mean age was 51.2 years (SD: 18.2; range: 19-79 years); 14 were male (56%) and 11 were female (44%). Seven study participants withdrew from study participation. Wound etiologies vary; 4 had diabetic foot ulcers; 1 had a full-thickness pressure injury; 7 were treated for management of an abscess or cyst; 4 had necrotizing fasciitis, 5 had nonhealing postsurgical wounds, and 4 had wounds of other etiologies. Data were collected at 2 ambulatory wound care clinics located in the Southeastern United States (Augusta and Austell, Georgia).
   METHODS: A single-outcome measure was selected for each participant by his or her attending physician at a baseline visit. Selected end points were (1) decrease in wound volume, (2) decrease in size of the tunneling area, (3) decrease in size of the undermining, (4) decrease in the amount of slough, (5) increase in granulation tissue formation, (6) decrease in periwound swelling, and (7) wound bed progression toward transition to another treatment modality (such as standard dressing, surgical closure, flap, or graft). Progress toward the individualized goal was monitored until the goal was achieved (study end point) or a maximum of 4 weeks following initiation of treatment.
   RESULTS: The most common primary treatment goal was to achieve a decrease in wound volume (22 of 25 study participants), and the goal to increase granulation tissue was chosen for the remaining 3 study participants. A majority of participants (18 of 23, 78.3%) reached their individualized treatment outcome. The remaining 5 participants (21.7%) were withdrawn during the study (for reasons not related to the therapy). The median (interquartile range [IQR]) duration of NPWT therapy was 19 days (IQR: 14-21 days). Between baseline and the final assessment, median reductions in wound area and volume were 42.7% (IQR: 25.7-71.5) and 87.5% (IQR: 30.7-94.6).
   CONCLUSIONS: The single-use NPWT system achieved multiple individualized treatment objectives in a variety of wound types. Individually selected goals of therapy were met by all study participants who completed the study.
C1 [Amin, Neha; Homsombath, Bounthavy; Rumbaugh, John; Craft-Coffman, Beretta; Fagan, Shawn P.; Chowdhry, Tayseer; Hassan, Zaheed] JMS Burn Ctr Inc, Austell, GA USA.
   [Amin, Neha; Homsombath, Bounthavy; Rumbaugh, John; Craft-Coffman, Beretta; Fagan, Shawn P.; Chowdhry, Tayseer; Hassan, Zaheed] Wellstar Hosp, Adv Wound Clin, Austell, GA USA.
   [Wilson, Joan] JMS Res Fdn Inc, Augusta, GA USA.
   [Lussi, Karin] Medela AG, Laettich Str, Baar, Switzerland.
RP Paglinawan, R (通讯作者)，Medela AG, Laettich Str 4b, CH-6340 Baar, Switzerland.
EM neha.amin@burncenters.com; v.homsombath@burncenters.com;
   john.rumbaugh@burncenters.com; beretta.coffman@burncenters.com;
   shawn.fagan@burncenters.com; tayseer.chowdhry@burncenters.com;
   joan.wilson@jmsresearchfoundation.org; rey.paglinawan@medela.com;
   karin.lussi@medela.com; zaheed.hassan@burncenters.com
FU Medela AG
FX Funding for writing of the manuscript and performance of this clinical
   study was provided by Medela AG. Rey Paglinawan and Karin Lussi are
   employees of Medela AG (Switzerland). For the remaining authors, no
   conflicts of interest were declared.
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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NR 11
TC 3
Z9 3
U1 2
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2023
VL 50
IS 3
BP 203
EP 208
DI 10.1097/WON.0000000000000967
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA T2UN4
UT WOS:001076587200006
PM 37146110
OA hybrid
DA 2026-07-24
ER
PT J
AU Lu, W
   Cao, Y
   Zeng, FH
   Chen, C
   Yang, ZY
   Qi, ZL
   Yang, XA
AF Lu, Wei
   Cao, Yan
   Zeng, Fanhua
   Chen, Chun
   Yang, Zhenyu
   Qi, Zuoliang
   Yang, Xiaonan
TI Surgical Treatment for Benign Lymphangioendothelioma After Two
   Incomplete Excisions: A Case and Literature Review
SO CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
LA English
DT Review
DE diagnosis lymphangiomatosis; Kaposi's sarcoma; angiosarcoma. acquired
   progressive lymphangioma; angiosarcoma; benign lymphangioendothelioma;
   lymphangioma; lymphangiomatosis
ID ACQUIRED PROGRESSIVE LYMPHANGIOMA; KAPOSIS-SARCOMA; CLINICOPATHOLOGICAL
   ANALYSIS; ANGIOENDOTHELIOMA; PATCH; SKIN
AB Benign lymphangioendothelioma (BL) is a rare, poorly identified, slow-growing benign vascular lesion characterized by asymptomatic, solitary, well-demarcated macules, or by mildly infiltrated plaque. We report a case of an atypical BL that arose as a tender, protuberant, flesh-colored mass with cyanotic vesicles, and then progressed to a persistent exudative wound after two incomplete excisions. The patient was also diagnosed with thoracic duct narrowing. Although the stenosis was removed by surgery, the right lower extremity ulceration and exudation did not improve. Thus, we performed a thorough excision and split-thickness skin graft transplant following vacuum sealing drainage, and eventually the patient had a favorable functional and cosmetic outcome. A biopsy revealed irregular, dilated vascular spaces lined with a single layer of flat endothelial cells extending from the superficial dermis to the subcutis that did not reach the striated muscles. Additionally, by reviewing the literature on BL, in this paper we summarize the diverse pathogenic, morphological, and immunohistochemical presentations for this rare disease, as well as the histopathological differential diagnosis of lymphangiomatosis, Kaposi's sarcoma, and angiosarcoma.
C1 [Lu, Wei; Zeng, Fanhua; Chen, Chun; Yang, Zhenyu; Qi, Zuoliang; Yang, Xiaonan] Chinese Acad Med Sci CAMS & Peking Union Med Coll, Plast Surg Hosp, Dept Hemangioma & Vasc Malformat, Beijing 100144, Peoples R China.
   [Cao, Yan] Chinese Acad Med Sci CAMS & Peking Union Med Coll, Plast Surg Hosp, Dept Pathol, Beijing, Peoples R China.
   [Zeng, Fanhua] Ningxiang Peoples Hosp, Dept Burn & Plast Surg, Ningxiang, Hunan, Peoples R China.
   [Chen, Chun] Shenzhen Longgang Dist Third Peoples Hosp, ENT Dept, Shenzhen, Guangdong, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Cancer Institute & Hospital - CAMS;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Cancer Institute & Hospital - CAMS; Peking Union Medical College
RP Yang, XA (通讯作者)，Chinese Acad Med Sci CAMS & Peking Union Med Coll, Plast Surg Hosp, Dept Hemangioma & Vasc Malformat, Beijing 100144, Peoples R China.
EM yxnan@aliyun.com
OI Lu, Wei/0000-0001-5396-4004
FU National Major Disease Multidisciplinary Diagnosis and Treatment
   Cooperation Project [1112320139]; National clinical key specialty
   construction project [23003]
FX Funding This study was financially supported by the National Major
   Disease Multidisciplinary Diagnosis and Treatment Cooperation Project
   (No.1112320139) and the National clinical key specialty construction
   project (23003) . The funding body played no role in the design of the
   study and collection, analysis, and interpretation of data and in
   writing the manuscript.
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NR 51
TC 2
Z9 2
U1 0
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7015
J9 CLIN COSMET INV DERM
JI CLIN. COSMET. INVESTIG. DERMATOL.
PY 2023
VL 16
BP 2697
EP 2719
DI 10.2147/CCID.S420019
PG 23
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA T3YX7
UT WOS:001077388300001
PM 37790904
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Deng, Z
   Long, ZS
   Chen, G
AF Deng, Zhuan
   Long, Zhi-Sheng
   Chen, Gang
TI Mini-Review: Tendon-Exposed Wound Treatments
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Review
DE Tendon-exposed wounds; refractory wound; wound healing
ID PLATELET-RICH PLASMA; SOFT-TISSUE DEFECTS; VACUUM-ASSISTED CLOSURE;
   ARTIFICIAL DERMIS; GROWTH-FACTOR; ACHILLES-TENDON; HYALURONIC-ACID;
   MANAGEMENT; SKIN; FLAP
AB Background Tendon-exposed wounds are complex injuries with challenging reconstructions and no unified treatment mode. Furthermore, insufficient tissue volume and blood circulation disorders affect healing, which increases pain for the patient and affects their families and caretakers.Review As modern medicine advances, considerable progress has been made in understanding and treating tendon-exposed wounds, and current research encompasses both macro-and micro-studies. Additionally, new treatment methods have emerged alongside the classic surgical methods, such as new dressing therapies, vacuum sealing drainage combination therapy, platelet-rich plasma therapy, and live-cell bioengineering.Conclusions This review summarizes the latest treatment methods for tendon-exposed wounds to provide ideas and improve their treatment.
C1 [Deng, Zhuan; Long, Zhi-Sheng; Chen, Gang] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Orthoped, Nanchang, Peoples R China.
   [Long, Zhi-Sheng] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Orthoped, 152 Aiguo Rd, Nanchang 330006, Jiangxi, Peoples R China.
C3 Nanchang Medical College; Nanchang Medical College
RP Long, ZS (通讯作者)，Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Orthoped, 152 Aiguo Rd, Nanchang 330006, Jiangxi, Peoples R China.
EM 723340988@qq.com
OI Long, Zhisheng/0000-0001-6239-0591
FU Not Applicable
FX Not Applicable
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NR 109
TC 3
Z9 3
U1 0
U2 12
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0894-1939
EI 1521-0553
J9 J INVEST SURG
JI J. Invest. Surg.
PD DEC 31
PY 2023
VL 36
IS 1
AR 2266758
DI 10.1080/08941939.2023.2266758
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA T4XK3
UT WOS:001078031300001
PM 37813390
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, JM
   Xing, H
   Chang, ZQ
AF Wang, Jingming
   Xing, Hao
   Chang, Zhengqi
TI Effects of different sponge implantation methods of negative pressure
   wound therapy on wound healing of deep surgical site infection after
   spinal surgery
SO PLOS ONE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; POSTOPERATIVE INFECTIONS;
   MANAGEMENT; PATIENT
AB PurposeAfter spinal surgery, negative pressure wound treatment (NPWT) improves deep surgical site infection (DSSI) wound healing. This research compared the healing benefits of two sponge implantation strategies in NPWT for DSSI.Methods21 patients with DSSI utilized NPWT to improve wound healing following spine surgery were followed from January 1, 2012 to December 31, 2021. After antibiotic treatment failure, all these patients with DSSI received extensive debridement and NPWT. They are grouped by sponge placement method: centripetal reduction and segment reduction. The two groups' hospital stays, NPWT replacement frequency, wound healing time, healing speed, and quality of wound healing (POSAS score) were compared.ResultsAll patients had been cured by the end of December 2022, and the mean follow-up time was 57.48 +/- 29.6 months. Surgical incision length did not vary across groups (15.75 +/- 7.61 vs. 15.46 +/- 7.38 cm, P = 0.747). The segmental reduction approach had shorter hospital stay and NPWT treatment times than the centripetal reduction method (39.25 +/- 16.04 vs. 77.38 +/- 37.24 days, P = 0.027). Although there is no statistically significant difference, the mean wound healing duration of segmental reduction group is faster than that of centripetal reduction group (0.82 +/- 0.39 vs 0.45 +/- 0.28 cm/d, P = 0.238), wound healing quality (POSAS) (33.54 +/- 8.63 vs 48.13 +/- 12.17, P = 0.408) is better in segmental reduction group, and NPWT replacement frequency (2.62 +/- 1.04 vs 3.88 +/- 1.25, P < .915) is smaller in segmental reduction group.ConclusionsNPWT heals wounds and controls infection. Segmental reduction method accelerates wound healing, reduces hospital stay, and improves wound quality compared to central reduction method.
C1 [Wang, Jingming; Xing, Hao; Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
EM 26766771@qq.com
RI ; hao, xing/ACN-7926-2022
OI Wang, Jing-ming/0000-0002-4499-2086; 
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NR 26
TC 3
Z9 3
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 28
PY 2023
VL 18
IS 9
AR e0291858
DI 10.1371/journal.pone.0291858
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA T5QM7
UT WOS:001078533700039
PM 37768971
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Dueppers, P
   Bozalka, R
   Kopp, R
   Menges, AL
   Reutersberg, B
   Schrimpf, C
   Rivero, FJM
   Zimmermann, A
AF Dueppers, Philip
   Bozalka, Roland
   Kopp, Reinhard
   Menges, Anna-Leonie
   Reutersberg, Benedikt
   Schrimpf, Claudia
   Rivero, Francisco Jose Moreno
   Zimmermann, Alexander
TI The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing
   Fasciitis of the Leg: Early Clinical Experience and Literature Review on
   Indications for Intact Fish Skin Grafts
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE intact fish skin; fish skin grafts; necrotizing fasciitis; wounds;
   chronic wounds; gangrene; skin substitutes; wound healing; negative
   pressure wound therapy; skin transplantation
ID DIABETIC FOOT ULCERS; VEIN-THROMBOSIS; DONOR SITES; MANAGEMENT; WOUNDS;
   MATRIX; OMEGA-3-FATTY-ACIDS; MULTICENTER; OUTCOMES; THERAPY
AB Background: Necrotizing fasciitis (NF) is a serious infectious disease that can initially place the patient's life in danger and, after successful surgical and antibiotic treatment, leaves extensive wounds with sometimes even exposed bones and tendons. Autologous skin grafts are not always possible or require adequate wound bed preparation. Novel intact fish skin grafts (iFSGs; Kerecis (R) Omega3 Wound, Kerecis hf, Isafjordur, Iceland) have already shown their potential to promote granulation in many other wound situations. Faster wound healing rates and better functional and cosmetic outcomes were observed due to their additionally postulated anti-inflammatory and analgesic properties. Therefore, iFSGs may also be essential in treating NF. We present our initial experience with iFSGs in treating leg wounds after NF and review the literature for the current spectrum of clinical use of iFSGs. Case Presentations: We present two male patients (aged 60 and 69 years) with chronic or acute postsurgical extensive leg ulcers six weeks and six days after necrotizing fasciitis, respectively. Both suffered from diabetes mellitus without vascular pathologies of the lower limbs. A single application of one pre-meshed (Kerecis (R) Graftguide) and one self-meshed 300 cm2 iFSG (Kerecis (R) Surgiclose) was performed in our operation room after extensive surgical debridement and single circles of negative wound pressure therapy. Application and handling were easy. An excellent wound granulation was observed, even in uncovered tibia bone and tendons, accompanied by pain relief in both patients. Neither complications nor allergic reactions occurred. The patients received autologous skin grafting with excellent functional and cosmetic outcomes. Conclusions: iFSGs have the potential to play a significant role in the future treatment of NF due to the fast promotion of wound granulation and pain relief. Our experience may encourage surgeons to use iFSGs in NF patients, although high-quality, large-sized studies are still required to confirm these results. The observed effects of iFSGs on wounds associated with NF may be transferred to other wound etiologies as well.
C1 [Dueppers, Philip; Bozalka, Roland; Kopp, Reinhard; Menges, Anna-Leonie; Reutersberg, Benedikt; Schrimpf, Claudia; Zimmermann, Alexander] Univ Zurich UZH, Univ Hosp Zurich USZ, Dept Vasc Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
   [Rivero, Francisco Jose Moreno] Univ Hosp Zurich USZ, Tissue Viabil Serv Wound Care, Ramistr 100, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP Dueppers, P (通讯作者)，Univ Zurich UZH, Univ Hosp Zurich USZ, Dept Vasc Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM dr.dueppers@gmail.com
RI ; Dueppers, Philip/AAO-3947-2021; Zimmermann, Alexander/ABB-2989-2020;
   Reutersberg, Benedikt/AAJ-3017-2021
OI Menges, Anna-Leonie/0000-0002-6870-3904; Dueppers,
   Philip/0000-0003-3741-0591; Zimmermann, Alexander/0000-0003-0635-8591;
   Schrimpf, Claudia/0000-0002-5546-0931; Reutersberg,
   Benedikt/0000-0002-9286-8223
FU Kerecis hf,Isafjordur, Iceland
FX This independent article was partially supported by an educational grant
   from Kerecis hf,Isafjordur, Iceland.
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NR 48
TC 16
Z9 19
U1 1
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2023
VL 12
IS 18
AR 6001
DI 10.3390/jcm12186001
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA T5YF4
UT WOS:001078736100001
PM 37762941
OA Green Submitted, Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Popescu, V
   Cauni, V
   Petrutescu, MS
   Rustin, MM
   Bocai, R
   Turculet, CR
   Doran, H
   Patrascu, T
   Lazar, AM
   Cretoiu, D
   Varlas, VN
   Mastalier, B
AF Popescu, Valentin
   Cauni, Victor
   Petrutescu, Marius Septimiu
   Rustin, Maria Madalina
   Bocai, Raluca
   Turculet, Cristina Rachila
   Doran, Horia
   Patrascu, Traian
   Lazar, Angela Madalina
   Cretoiu, Dragos
   Varlas, Valentin Nicolae
   Mastalier, Bogdan
TI Chronic Wound Management: From Gauze to Homologous Cellular Matrix
SO BIOMEDICINES
LA English
DT Review
DE chronic wounds; regenerative medicine; complex wounds
ID DIABETIC FOOT ULCER; VENOUS LEG ULCERS; CLASSIFICATION-SYSTEM;
   COMPRESSION THERAPY; BED PREPARATION; STEM-CELLS; DRESSINGS; HEALTH;
   CARE; INFECTIONS
AB Background: Chronic wounds are a significant health problem with devastating consequences for patients' physical, social, and mental health, increasing healthcare systems' costs. Their prolonged healing times, economic burden, diminished quality of life, increased infection risk, and impact on patients' mobility and functionality make them a major concern for healthcare professionals. Purpose: This review offers a multi-perspective analysis of the medical literature focusing on chronic wound management. Methods used: We evaluated 48 articles from the last 21 years registered in the MEDLINE and Global Health databases. The articles included in our study had a minimum of 20 citations, patients > 18 years old, and focused on chronic, complex, and hard-to-heal wounds. Extracted data were summarized into a narrative synthesis using the same health-related quality of life instrument. Results: We evaluated the efficacy of existing wound care therapies from classical methods to modern concepts, and wound care products to regenerative medicine that uses a patient's pluripotent stem cells and growth factors. Regenerative medicine and stem cell therapies, biologic dressings and scaffolds, negative pressure wound therapy (NPWT), electrical stimulation, topical growth factors and cytokines, hyperbaric oxygen therapy (HBOT), advanced wound dressings, artificial intelligence (AI), and digital wound management are all part of the new arsenal of wound healing. Conclusion: Periodic medical evaluation and proper use of modern wound care therapies, including the use of plasma-derived products [such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF)] combined with proper systemic support (adequate protein levels, blood sugar, vitamins involved in tissue regeneration, etc.) are the key to a faster wound healing, and, with the help of AI, can reach the fastest healing rate possible.
C1 [Popescu, Valentin; Petrutescu, Marius Septimiu; Lazar, Angela Madalina; Mastalier, Bogdan] Colentina Clin Hosp, Gen Surg Clin, Bucharest 020125, Romania.
   [Popescu, Valentin; Rustin, Maria Madalina; Bocai, Raluca; Turculet, Cristina Rachila; Doran, Horia; Patrascu, Traian; Lazar, Angela Madalina; Mastalier, Bogdan] Carol Davila Univ Med & Pharm, Gen Surg Dept, 8 Eroii Sanitari Blvd, Bucharest 050474, Romania.
   [Cauni, Victor] Colentina Clin Hosp, Urol Clin, Bucharest 020125, Romania.
   [Doran, Horia; Patrascu, Traian] Dr I Cantacuzino Clin Hosp, Prof I Juvara Gen Surg Clin, Bucharest 011437, Romania.
   [Cretoiu, Dragos] Alessandrescu Rusescu Natl Inst Mother & Child Hlt, Fetal Med Excellence Res Ctr, Bucharest 020395, Romania.
   [Cretoiu, Dragos] Carol Davila Univ Med & Pharm, Dept Genet, 8 Eroii Sanitari Blvd, Bucharest 050474, Romania.
   [Varlas, Valentin Nicolae] Filantropia Clin Hosp, Dept Obstet & Gynaecol, Bucharest 011171, Romania.
   [Varlas, Valentin Nicolae] Carol Davila Univ Med & Pharm, Dept Obstet & Gynaecol, 37 Dionisie Lupu St, Bucharest 020021, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Cretoiu, D (通讯作者)，Alessandrescu Rusescu Natl Inst Mother & Child Hlt, Fetal Med Excellence Res Ctr, Bucharest 020395, Romania.; Cretoiu, D (通讯作者)，Carol Davila Univ Med & Pharm, Dept Genet, 8 Eroii Sanitari Blvd, Bucharest 050474, Romania.; Varlas, VN (通讯作者)，Filantropia Clin Hosp, Dept Obstet & Gynaecol, Bucharest 011171, Romania.; Varlas, VN (通讯作者)，Carol Davila Univ Med & Pharm, Dept Obstet & Gynaecol, 37 Dionisie Lupu St, Bucharest 020021, Romania.
EM popescu.vali.umf@gmail.com; victorcauni@yahoo.com;
   mariuspetrutescu@yahoo.co.uk; mariamadalinarustin@gmail.com;
   raluca.bocai@gmail.com; cristina_turculet22@yahoo.com;
   doranh2003@yahoo.com; patrascutraian@gmail.com;
   angelalazar.2008@yahoo.com; dragos@cretoiu.ro; valentin.varlas@umfcd.ro;
   bogdanmastalier@yahoo.com
RI Cretoiu, agos/G-3741-2011; /Z-5965-2019; Varlas, Valentin
   Nicolae/ABI-5875-2020; Popescu, Valentin/J-2905-2016; Lazar, Angela
   Madalina/AAL-2021-2021; DORAN, HORIA/N-9456-2013; Cretoiu,
   Dragos/G-3741-2011
OI Cretoiu, agos/0000-0003-3214-030X; Mastalier,
   Bogdan/0000-0003-3179-7350; Varlas, Valentin
   Nicolae/0000-0002-8342-9819; Popescu, Valentin/0000-0002-1317-4937;
   Lazar, Angela Madalina/0000-0002-3258-2311; 
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NR 77
TC 41
Z9 44
U1 5
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD SEP
PY 2023
VL 11
IS 9
AR 2457
DI 10.3390/biomedicines11092457
PG 15
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA T7OY6
UT WOS:001079851800001
PM 37760898
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Onderkova, A
   Butler, PEM
   Kalavrezos, N
AF Onderkova, Anna
   Butler, Peter E. M.
   Kalavrezos, Nicholas
TI The efficacy of negative-pressure wound therapy for head and neck
   wounds: A systematic review and update
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Review
DE head and neck wounds; negative-pressure wound therapy; systematic
   review; wound healing
ID THICKNESS SKIN-GRAFTS; SPACE INFECTIONS; MANAGEMENT; FLAP
AB Despite the established benefits of negative-pressure wound therapy (NPWT) in various wound healing contexts, its application in head and neck surgical cases remains under-explored. This study aimed to systematically review its effectiveness, safety, and comparative efficacy. Thirty-one studies from a systematic literature search were identified and analyzed for wound healing response, overall success rate, improvements compared to conventional wound care, and variation in pressure settings, treatment lengths, and dressing change frequency. NPWT showed enhanced outcomes across diverse head and neck wounds, particularly complex post-reconstructive wounds and severe infections. Despite the predominantly case report/series evidence and lack of standardized NPWT protocols, its benefits over conventional care were clear. NPWT emerges as a promising approach for head and neck wound management, potentially improving patient outcomes and reducing complications. More randomized controlled trials are needed to solidify the evidence and standardize NPWT application protocols.
C1 [Onderkova, Anna; Butler, Peter E. M.] Royal Free Hosp, Charles Wolfson Ctr Reconstruct Surg, London, England.
   [Onderkova, Anna; Kalavrezos, Nicholas] Univ Coll London Hosp UCLH, Dept Head & Neck, London, England.
   [Butler, Peter E. M.] Royal Free Hosp, Dept Plast Surg, London, England.
   [Onderkova, Anna] Royal Free Hosp, Charles Wolfson Ctr Reconstruct Surg, London, England.
C3 University of London; University College London; Royal Free London NHS
   Foundation Trust; UCL Medical School; University College London
   Hospitals NHS Foundation Trust; University of London; University College
   London; UCL Medical School; Royal Free London NHS Foundation Trust;
   University of London; University College London; UCL Medical School;
   Royal Free London NHS Foundation Trust
RP Onderkova, A (通讯作者)，Royal Free Hosp, Charles Wolfson Ctr Reconstruct Surg, London, England.
EM annaonderkova@doctors.org.uk
RI Onderková, Anna/HDO-7019-2022
OI Onderková, Anna/0000-0002-4383-3040; Butler, Peter/0000-0001-7419-1493
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NR 43
TC 6
Z9 9
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD DEC
PY 2023
VL 45
IS 12
BP 3168
EP 3179
DI 10.1002/hed.27547
EA OCT 2023
PG 12
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA X7PI4
UT WOS:001086035200001
PM 37860929
OA hybrid
DA 2026-07-24
ER
PT J
AU Wen, CWY
   Nasir, FABM
   Charl, MK
   Jane, CA
   Abdullah, NSKH
   Ping, LB
   Nair, HKR
AF Wen, Clarissa Wong Yi
   Nasir, Fatini Aina Binti Mohamad
   Charl, Manjageeta Kaur
   Jane, Chew Ait
   Abdullah, Nur Sarimah Kamilia Hoo
   Ping, Lim Boon
   Nair, Harikrishna K. R.
TI Use of a portable negative pressure wound therapy device on a
   hard-to-heal wound with exposed bone: a case study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE chronic; exposed bone; exudate; hard-to; heal; negative pressure wound
   therapy; wound; wound care; wound dressing; wound healing
AB This case study examines the effectiveness of using negative pressure wound therapy (NPWT) in the management of a hard-to-heal (chronic) wound with exposed ankle bone to reduce associated wound exudate and promote production of granulation tissue. A 60-year-old male patient who was able to attend wound follow-up diligently twice weekly for eight weeks, and weekly thereafter, was selected from a private hospital to take part. During each dressing change, the wound was cleansed with superoxidised cleansing solution, and minimal sharp debridement was performed. In the authors' opinion, the NPWT device used in this study is light and convenient for use in the community or home care setting. The NPWT wound dressing was connected to the NPWT machine via a connecting tube and the device then switched on using the default setting of a negative pressure of 125mmHg. Following the application of the NPWT device, the exposed ankle bone was successfully covered with healthy granulation tissue and healed within 20 weeks with minimal exudate formation in the wound. In the authors' opinion, NPWT is able to promote progress to wound healing; to minimise unnecessary dressing changes and, based on feedback from the patient, is comfortable to wear and when in use.
C1 [Wen, Clarissa Wong Yi] Soza Healthcare Sdn Bhd, Petaling Jaya, Malaysia.
   [Nasir, Fatini Aina Binti Mohamad] Klin TTDI Bangi, Bandar Baru Bangi, Malaysia.
   [Charl, Manjageeta Kaur] Klin Naam Care, Puchong, Malaysia.
   [Jane, Chew Ait] Klin Kesihatan Jelapang, Ipoh, Malaysia.
   [Abdullah, Nur Sarimah Kamilia Hoo] Gleneagles Med Ctr, Jerudong, Brunei.
   [Ping, Lim Boon] Subang Jaya Med Ctr, Subang Jaya, Malaysia.
   [Nair, Harikrishna K. R.] Hosp Kuala Lumpur, Dept Internal Med, Wound Care Unit, Kuala Lumpur, Malaysia.
RP Wen, CWY (通讯作者)，Soza Healthcare Sdn Bhd, Petaling Jaya, Malaysia.
EM Claire8688@gmail.com
CR Agarwal A, 2022, J ORTHOP TRAUMA, V36, pS1, DOI 10.1097/BOT.0000000000002431
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   Lee Hyun-Joo, 2009, J Orthop Surg Res, V4, P14, DOI 10.1186/1749-799X-4-14
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NR 11
TC 1
Z9 1
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2023
VL 32
SU 10A
BP S16
EP S20
DI 10.12968/jowc.2023.32.Sup10a.S16
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA U8LW9
UT WOS:001087271800003
PM 37830842
DA 2026-07-24
ER
PT J
AU Qiu, XT
   Luo, HM
   Huang, GB
AF Qiu, Xiaotong
   Luo, Haoming
   Huang, Guobao
TI Roles of negative pressure wound therapy for scar revision
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE burns; negative pressure wound therapy; scar revision; skin
   transplantation; flap transplantation
ID VACUUM SEALING DRAINAGE; THICKNESS SKIN-GRAFTS; FOOT; MANAGEMENT;
   INFECTION
AB The purpose of this study is to review the research progress of negative pressure wound therapy (NPWT) for scar revision and discuss the prospects of its further study and application. The domestic and foreign literatures on NPWT for scar revision were reviewed. The mechanism and application were summarized. NPWT improves microcirculation and lymphatic flow and stimulates the growth of granulation tissues in addition to draining secretions and necrotic tissue. As a significant clinical therapy in scar revision, NPWT reduces tension, fixes graft, and improves wound bed. In the field of scar revision, NPWT has been increasingly used as an innovative and constantly improving technology.
C1 [Qiu, Xiaotong] Weifang Med Univ, Sch Clin Med, Affiliated Hosp, Weifang, Peoples R China.
   [Qiu, Xiaotong; Huang, Guobao] Jinan Cent Hosp, Dept Burns & Plast Surg, Jinan, Peoples R China.
   [Luo, Haoming] Third Hosp Mianyang & Sichuan Mental Hlth Ctr, Dept Thyroid Head Neck & Maxillofacial Surg, Mianyang, Peoples R China.
   [Huang, Guobao] Shandong First Med Univ, Dept Burns & Plast Surg, Cent Hosp, Jinan, Peoples R China.
C3 Shandong Second Medical University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong First Medical University
   & Shandong Academy of Medical Sciences
RP Huang, GB (通讯作者)，Jinan Cent Hosp, Dept Burns & Plast Surg, Jinan, Peoples R China.; Huang, GB (通讯作者)，Shandong First Med Univ, Dept Burns & Plast Surg, Cent Hosp, Jinan, Peoples R China.
EM 13370582872@126.com
RI Qiu, Xiaotong/HMD-6765-2023
FU Supported by the Shandong First Medical University Youth Science
   Foundation Training Funding Program (202201-130). [202201-130]; Shandong
   First Medical University Youth Science Foundation
FX Thanks to the handsome and warm-hearted Xiaodong Sun for the guidance of
   English writing.r Supported by the Shandong First Medical University
   Youth Science Foundation Training Funding Program (202201-130).
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NR 60
TC 2
Z9 3
U1 1
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD OCT 12
PY 2023
VL 14
AR 1194051
DI 10.3389/fphys.2023.1194051
PG 6
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA U8NS2
UT WOS:001087320200001
PM 37900944
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ravindhran, B
   Schafer, N
   Howitt, A
   Carradice, D
   Smith, G
   Chetter, I
AF Ravindhran, Bharadhwaj
   Schafer, Nicole
   Howitt, Annabel
   Carradice, Daniel
   Smith, George
   Chetter, Ian
TI Molecular mechanisms of action of negative pressure wound therapy: a
   systematic review
SO EXPERT REVIEWS IN MOLECULAR MEDICINE
LA English
DT Review
DE biomarkers; molecular mechanisms; negative-pressure wound therapy; wound
   care; wound healing
ID VACUUM-ASSISTED CLOSURE; EXPRESSION; STRESS; FIBRONECTIN; ANGIOGENESIS;
   RESPONSES; SWINE; FLUID
AB Negative pressure wound therapy (NPWT) has significantly advanced wound care and continues to find new applications. Its effects at a molecular level however, remain a subject of debate. The aim of this systematic review is to summarize the current evidence regarding the molecular mechanisms of action of NPWT. Medline, Embase, EBSCO databases and clinical trial registries were searched from inception to January 2023. Clinical studies, animal models or in-vitro studies that quantitatively or semi-quantitatively evaluated the influence of NPWT on growth factors, cytokine or gene-expression in the circulation or wound-bed were included. Risk of Bias assessment was performed using the RoBANS tool for non-randomized studies, the COCHRANE's Risk of Bias 2(ROB-2) tool for randomized clinical studies, OHAT tool for in-vitro studies or the SYRCLE tool for animal model studies. A descriptive summary was collated and the aggregated data is presented as a narrative synthesis. This review included 19 clinical studies, 11 animal studies and 3 in-vitro studies. The effects of NPWT on 43 biomarkers and 17 gene expressions were studied across included studies. NPWT stimulates modulation of numerous local and circulating cytokines and growth factor expressions to promote an anti-inflammatory profile. This is most likely achieved by downregulation of TNF alpha, upregulation of VEGF, TGF-beta and fibronectin.
C1 [Ravindhran, Bharadhwaj; Schafer, Nicole; Howitt, Annabel; Carradice, Daniel; Smith, George; Chetter, Ian] Hull Royal Infirm, Acad Vasc Surg Unit, Kingston Upon Hull, England.
   [Ravindhran, Bharadhwaj] Univ York, Dept Hlth Sci, York, England.
C3 University of Hull; University of York - UK
RP Ravindhran, B (通讯作者)，Hull Royal Infirm, Acad Vasc Surg Unit, Kingston Upon Hull, England.; Ravindhran, B (通讯作者)，Univ York, Dept Hlth Sci, York, England.
EM bharadhwaj.ravindhran@nhs.net
RI ; Carradice, Daniel/AFN-0257-2022; Ravindhran, Bharadhwaj/IQU-6793-2023
OI Schafer, Nicole/0009-0000-9940-1039; Smith, George/0000-0002-8085-0886;
   chetter, ian/0000-0002-2566-6859; Carradice, Daniel/0000-0002-7733-3925;
   Ravindhran, Bharadhwaj/0000-0003-0778-2191
FU The authors would like to thank the Academic vascular Surgical Unit at
   Hull Royal Infirmary for their support with this article.
FX The authors would like to thank the Academic vascular Surgical Unit at
   Hull Royal Infirmary for their support with this article.
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NR 71
TC 16
Z9 18
U1 2
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1462-3994
J9 EXPERT REV MOL MED
JI Expert Rev. Mol. Med.
PD OCT 19
PY 2023
VL 25
AR e29
DI 10.1017/erm.2023.24
PG 10
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA U8TD3
UT WOS:001087461800001
PM 37853784
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Salinaro, JR
   Jones, PS
   Beatty, AB
   Dotters-Katz, SK
   Kuller, JA
   Kerner, NP
AF Salinaro, Julia R.
   Jones, Penny S.
   Beatty, Amelia B.
   Dotters-Katz, Sarah K.
   Kuller, Jeffrey A.
   Kerner, Nicole P.
TI Optimizing Surgical Wound Care in Obstetrics and Gynecology
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Review
ID BED PREPARATION; OBESE WOMEN; CESAREAN DELIVERY; SITE INFECTION;
   SURGERY; THERAPY; LAPAROTOMY; RECLOSURE; CLOSURE; HEALTH
AB Importance: Obstetrics and gynecology (OB/GYN) accounts for at least half of all open abdominal surgeries performed. Rates of surgical wound complications after open procedures in OB/GYN range from 5% to 35%. Therefore, optimizing management of surgical wound complications has the potential to significantly reduce cost and morbidity. However, guidelines addressing best practices for wound care in OB/GYN are limited.Objective: The objectives of this review are to describe the fundamentals of wound healing and to evaluate available evidence addressing surgical wound care. Based on these data, we provide recommendations for management of extrafascial surgical wound dehiscence after OB/GYN procedures.Evidence Acquisition: Literature search was performed in PubMed, Medline, OVID, and the Cochrane database. Relevant guidelines, systematic reviews, and original research articles investigating mechanisms of wound healing, types of wound closure, and management of surgical wound complications were reviewed.Results: Surgical wound complications in OB/GYN are associated with significant cost and morbidity. One of the most common complications is extrafascial dehiscence, which may occur in the setting of hematomas, seromas, or infection. Management includes early debridement and treatment of any underlying infection until healthy granulation tissue is present. For wounds healing by secondary intention, advanced moisture retentive dressings reduce time to healing and are cost-effective when compared with conventional wet-to-dry gauze dressings. Negative pressure wound therapy can be applied to deeper wounds healing by secondary intention. Review of published evidence also supports the use of delayed reclosure to expedite wound healing for select patients.Conclusions: Optimizing surgical wound care has the potential to reduce the cost and morbidity associated with surgical wound complications in OB/GYN. Advanced moisture retentive dressings should be considered for wounds healing by secondary intention. Data support delayed reclosure for select patients, although further studies are needed.Target Audience: Obstetricians and gynecologists, family physicians.Learning Objectives: After reading this article, the provider will be better able to explain the clinical significance of surgical wound complications, particularly in OB/GYN; identify the stages of wound healing and types of wound closure; discuss the TIME framework for wound care; and describe a recommended approach for the management of extrafascial wound dehiscence.
C1 [Salinaro, Julia R.; Jones, Penny S.; Beatty, Amelia B.; Dotters-Katz, Sarah K.; Kuller, Jeffrey A.; Kerner, Nicole P.] Duke Univ, Dept Obstet & Gynecol, Durham, NC USA.
   [Salinaro, Julia R.] Duke Univ, Dept Obstet & Gynecol, 200 Trent Dr, Durham, NC 27710 USA.
C3 Duke University; Duke University
RP Salinaro, JR (通讯作者)，Duke Univ, Dept Obstet & Gynecol, 200 Trent Dr, Durham, NC 27710 USA.
EM julia.salinaro@gmail.com; penny.jones@duke.edu; amelia.beatty@duke.edu;
   sarah.dotters-katz@duke.edu; jeffrey.kuller@duke.edu;
   nicole.kerner@duke.edu
OI Kerner, Nicole/0000-0003-4987-7973
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NR 45
TC 6
Z9 7
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD OCT
PY 2023
VL 78
IS 10
BP 598
EP 605
DI 10.1097/OGX.0000000000001204
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA W1BE2
UT WOS:001089041700008
PM 37976315
DA 2026-07-24
ER
PT J
AU Yang, RF
   Hua, HT
   Wang, XW
   Guo, ZR
   Zhong, WL
AF Yang, Ruifang
   Hua, Haotian
   Wang, Xinwei
   Guo, Zairan
   Zhong, Wenlong
TI Vacuum sealing drainage combined with eggshell-like debridement
   antibiotic-loaded calcium sulphate for calcaneal osteomyelitis
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Eggshell-like debridement; Vacuum sealing drainage; Antibiotic-loaded
   calcium sulphate; Calcaneal osteomyelitis
AB Background To compare the clinical efficacy of vacuum sealing drainage, eggshell-like debridement combined with antibiotic calcium sulphate implantation and conventional debridement combined with antibiotic calcium sulphate implantation in the treatment of calcaneal osteomyelitis. Methods Sixty-six patients with calcaneal osteomyelitis who were treated in our department between January 2017 and August 2021 were included in this study. Thirty-one patients underwent VSD and eggshell-like debridement combined with antibiotic calcium sulphate implantation. Thirty-five patients underwent conventional debridement combined with antibiotic calcium sulphate implantation. The inflammatory markers, operation time, wound healing time, hospital stay, full weight bearing time after operation, recurrence rate of infection, complications, and American Orthopedic Foot and Ankle Society (AOFAS) scores were compared between the two groups. Results The operation time and full weight bearing time after operation of observation group were longer than that of control group. Compared with preoperative results, WBC, ESR, CRP and PCT in both groups were significantly decreased at 14 days after operation, and there was no statistical significance between the two groups. The wound healing time and hospital stay in the observation group were shorter than those in the control group (P < 0.05). There were four patients with aseptic exudation in the observation group and ten patients with aseptic exudation in the control group, and the wounds healed well after multiple dressing changes. Seven patients in the observation group underwent secondary bone grafting due to bone defects, and four patients in the control group received secondary bone grafting due to bone defects. In the observation group, three patients received debridement combined with antibiotic calcium sulphate implantation again due to recurrent infection, compared with seven patients in the control group. One year after operation, the observation group had a better AOFAS scores than the control group, especially in terms of foot function (P < 0.05). Conclusion Compared with conventional debridement and antibiotic calcium sulphate implantation, VSD and eggshell-like debridement combined with antibiotic calcium sulphate implantation in the treatment of calcaneal osteomyelitis can shorten the wound healing and hospital stay of patients, reduce postoperative aseptic exudation complications and infection recurrence rate, and better preserve the foot function, which is a simple and effective method.
C1 [Yang, Ruifang; Wang, Xinwei; Guo, Zairan; Zhong, Wenlong] Luoyang Orthoped Traumatol Hosp Henan Prov, Dept Bone & Joint Infect, Luoyang, Peoples R China.
   [Yang, Ruifang] Henan Univ Tradit Chinese Med, Degree & Grad Educ Luoyang Work Dept, Luoyang, Peoples R China.
   [Hua, Haotian] Zhejiang Chinese Med Univ, Sch Clin Med 1, Hangzhou, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Zhejiang Chinese
   Medical University
RP Wang, XW (通讯作者)，Luoyang Orthoped Traumatol Hosp Henan Prov, Dept Bone & Joint Infect, Luoyang, Peoples R China.
EM lywxw188@163.com
FU We would like to thank all the patients who participated in the study
   for their cooperation.
FX We would like to thank all the patients who participated in the study
   for their cooperation.
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NR 21
TC 6
Z9 6
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD OCT 24
PY 2023
VL 18
IS 1
AR 796
DI 10.1186/s13018-023-04259-6
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA W1IF2
UT WOS:001089226700005
PM 37875933
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Roberts, DJ
   Leppäniemi, A
   Tolonen, M
   Mentula, P
   Björck, M
   Kirkpatrick, AW
   Sugrue, M
   Pereira, BM
   Petersson, U
   Coccolini, F
   Latifi, R
AF Roberts, Derek J.
   Leppaniemi, Ari
   Tolonen, Matti
   Mentula, Panu
   Bjorck, Martin
   Kirkpatrick, Andrew W.
   Sugrue, Michael
   Pereira, Bruno M.
   Petersson, Ulf
   Coccolini, Federico
   Latifi, Rifat
TI The open abdomen in trauma, acute care, and vascular and endovascular
   surgery: comprehensive, expert, narrative review
SO BJS OPEN
LA English
DT Review
ID ABDOMINAL COMPARTMENT SYNDROME; MEDIATED FASCIAL TRACTION;
   DAMAGE-CONTROL LAPAROTOMY; PRESSURE WOUND THERAPY; POSTERIOR COMPONENT
   SEPARATION; AORTIC-ANEURYSM; CRITICALLY-ILL; INTRAABDOMINAL
   HYPERTENSION; ENTEROATMOSPHERIC FISTULAS; PERITONEAL RESUSCITATION
AB Background The open abdomen is an innovation that greatly improved surgical understanding of damage control, temporary abdominal closure, staged abdominal reconstruction, viscera and enteric fistula care, and abdominal wall reconstruction. This article provides an evidence-informed, expert, comprehensive narrative review of the open abdomen in trauma, acute care, and vascular and endovascular surgery.Methods A group of 12 international trauma, acute care, and vascular and endovascular surgery experts were invited to review current literature and important concepts surrounding the open abdomen.Results The open abdomen may be classified using validated systems developed by a working group in 2009 and modified by the World Society of the Abdominal Compartment Syndrome-The Abdominal Compartment Society in 2013. It may be indicated in major trauma, intra-abdominal sepsis, vascular surgical emergencies, and severe acute pancreatitis; to facilitate second look laparotomy or avoid or treat abdominal compartment syndrome; and when the abdominal wall cannot be safely closed. Temporary abdominal closure and staged abdominal reconstruction methods include a mesh/sheet, transabdominal wall dynamic fascial traction, negative pressure wound therapy, and hybrid negative pressure wound therapy and dynamic fascial traction. This last method likely has the highest primary fascial closure rates. Direct peritoneal resuscitation is currently an experimental strategy developed to improve primary fascial closure rates and reduce complications in those with an open abdomen. Primary fascial closure rates may be improved by early return to the operating room; limiting use of crystalloid fluids during the surgical interval; and preventing and/or treating intra-abdominal hypertension, enteric fistulae, and intra-abdominal collections after surgery. The majority of failures of primary fascial closure and enteroatmospheric fistula formation may be prevented using effective temporary abdominal closure techniques, providing appropriate resuscitation fluids and nutritional support, and closing the abdomen as early as possible.Conclusion Subsequent stages of the innovation of the open abdomen will likely involve the design and conduct of prospective studies to evaluate appropriate indications for its use and effectiveness and safety of the above components of open abdomen management.
   The open abdomen is an innovation that greatly improved surgical understanding of temporary abdominal closure indications, techniques, and outcomes. We provide an evidence-informed, expert, comprehensive narrative review of the open abdomen. Subsequent stages of the innovation of the open abdomen will likely involve the design and conduct of prospective studies to evaluate appropriate indications for its use and effectiveness and safety of the above components of open abdomen management.
C1 [Roberts, Derek J.] Univ Ottawa, Dept Surg, Div Vasc & Endovasc Surg, Ottawa, ON, Canada.
   [Roberts, Derek J.] Ottawa Hosp, Ottawa, ON, Canada.
   [Roberts, Derek J.] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
   [Roberts, Derek J.] Ottawa Hosp, Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
   [Leppaniemi, Ari; Tolonen, Matti; Mentula, Panu] Helsinki Univ Hosp, Abdominal Ctr, Dept Abdominal Surg, Helsinki, Finland.
   [Leppaniemi, Ari; Tolonen, Matti; Mentula, Panu] Univ Helsinki, Helsinki, Finland.
   [Bjorck, Martin] Uppsala Univ, Dept Surg Sci, Vasc Surg, Uppsala, Sweden.
   [Kirkpatrick, Andrew W.] TeleMentored Ultrasound Supported Med Intervent T, Calgary, AB, Canada.
   [Kirkpatrick, Andrew W.] Univ Calgary, Dept Surg, Calgary, AB, Canada.
   [Kirkpatrick, Andrew W.] Univ Calgary, Dept Crit Care Med, Calgary, AB, Canada.
   [Sugrue, Michael] Univ Hosp Donegal, Dept Surg Letterkenny, Donegal, Ireland.
   [Pereira, Bruno M.] Vassouras Univ, Masters Program Hlth Appl Sci, Dept Surg, Vassouras, RJ, Brazil.
   [Pereira, Bruno M.] Campinas Holy House Gen Surg Residency Program, Dept Surg, Campinas, SP, Brazil.
   [Petersson, Ulf] Skane Univ Hosp, Dept Surg, Malmo, Sweden.
   [Petersson, Ulf] Lund Univ, Dept Clin Sci, Lund, Sweden.
   [Coccolini, Federico] Pisa Univ Hosp, Dept Gen Emergency & Trauma Surg, Pisa, Italy.
   [Latifi, Rifat] Westchester Med Ctr, Dept Surg, Valhalla, NY USA.
C3 University of Ottawa; University of Ottawa; Ottawa Hospital Research
   Institute; University of Ottawa; University of Ottawa; Ottawa Hospital
   Research Institute; University of Helsinki; Helsinki University Central
   Hospital; University of Helsinki; Uppsala University; University of
   Calgary; University of Calgary; Lund University; Skane University
   Hospital; Lund University; University of Pisa; Azienda Ospedaliero
   Universitaria Pisana; Westchester Medical Center
RP Leppäniemi, A (通讯作者)，Meilahti Tower Hosp, Haartmaninkatu 4, HUS-00029 Helsinki, Finland.
EM Leppis54@outlook.com
RI Coccolini, Federico/AAJ-6507-2020; Mentula, Panu/H-9025-2019; , Pereira
   BM/D-4542-2015; Latifi, Rifat/JPX-2945-2023; Leppäniemi,
   Ari/GQZ-7991-2022; Roberts, Derek/L-6229-2019; Tolonen,
   Matti/I-9970-2019
OI Coccolini, Federico/0000-0001-6364-4186; Mentula,
   Panu/0000-0002-6516-3797; , Pereira BM/0000-0003-3763-1749; 
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NR 135
TC 27
Z9 41
U1 2
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD SEP 5
PY 2023
VL 7
IS 5
AR zrad084
DI 10.1093/bjsopen/zrad084
PG 17
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA W1MR4
UT WOS:001089344100001
PM 37882630
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Greene, B
   Lagrotteria, A
   Tsang, ME
   Jayaraman, S
AF Greene, Brittany
   Lagrotteria, Andrew
   Tsang, Melanie E.
   Jayaraman, Shiva
TI Closed incision negative pressure wound therapy following
   pancreaticoduodenectomy for prevention of surgical site infections in
   high-risk patients
SO CANADIAN JOURNAL OF SURGERY
LA English
DT Article
ID PANCREATIC FISTULA; IMPACT; COMPLICATIONS
AB Background:Surgical site infection (SSI) is one of the most common sources of morbidity after pancreaticoduodenectomy. Surgical site infections are associated with readmissions, prolonged length of stay, delayed initiation of adjuvant chemotherapy and negative effects on quality of life. Incisional vacuum-assisted closure (iVAC) devices applied on closed incisions may reduce SSI rates. The objective of this retrospective review is to evaluate the impact of iVAC on SSI rate after pancreaticoduodenectomy.Methods:A cohort of patients undergoing pancreaticoduodenectomy at a single institution who had at least 1 risk factor for SSI and who received an iVAC were compared with a historical cohort of high-risk patients who received conventional dressings after pancreaticoduodenectomy. The primary outcome was incidence of SSI within 30 days, abstracted from chart review. Secondary outcomes were 30-day readmission, 90-day mortality, rate of postoperative pancreatic fistula and rate of delayed gastric emptying.Results:In total, 175 patients were included, of whom 61 received an iVAC. The incidence of SSI was 13% (8 of 61 patients) and 16% (18 of 114 patients) in the iVAC and conventional dressing groups, respectively (odds ratio 0.81, 95% confidence interval 0.33-1.98). Preoperative biliary drainage was the most frequent SSI risk factor. Binary logistic regression using SSI as the outcome demonstrated no significant association with iVAC use when adjusted for SSI risk factors. There were no differences in rates of postoperative pancreatic fistula, delayed gastric emptying or 90-day mortality.Conclusion:This report describes the outcomes of the integration of iVAC devices into routine clinical practice at a high-volume institution. Application of this device after pancreaticoduodenectomy for patients at elevated risk of SSI was not associated with a reduction in the rate of SSIs.
   Contexte:L'infection de la plaie operatoire (IPO) est l'une des principales causes de morbidite apres la pancreatoduodenectomie. Les IPO sont associees a des readmissions, au prolongement des sejours hospitaliers et au report de la chimiotherapie adjuvante, en plus de nuire a la qualite de vie. Le traitement des plaies par pression negative (TPN) applique sur des incisions refermees pourrait reduire les taux d'IPO. Cette etude retrospective avait pour objectif de mesurer l'impact du TPN sur le taux d'IPO apres la pancreatoduodenectomie.Methodes:Dans un seul et meme etablissement, une cohorte de malades soumis a une pancreatoduodenectomie presentant au moins 1 facteur de risque d'IPO et ayant beneficie du TPN a ete comparee a une cohorte historique de cas a risque eleve chez qui on a applique des pansements classiques apres la pancreatoduodenectomie. Le parametre principal etait l'incidence des IPO dans les 30 jours suivant l'intervention, selon la revue des dossiers. Les parametres secondaires etaient les readmissions dans les 30 jours, la mortalite dans les 90 jours, et les taux de fistules postoperatoires et de retards de la vidange gastrique.Resultats:En tout, 175 malades ont ete inclus, dont 61 ont recu le TPN. L'incidence des IPO a ete de 13 % (8 malades sur 61) et de 16 % (18 malades sur 114) dans les groupes ayant recu le TPN et les pansements classiques, respectivement (rapport des cotes 0,81, intervalle de confiance de 95 % 0,33-1,98). Le drainage biliaire preoperatoire etait le facteur de risque d'IPO le plus frequent. La regression logistique binaire avec l'IPO comme parametre n'a permis d'etablir aucun lien significatif avec le TPN apres ajustement pour tenir compte des facteurs de risque d'IPO. On n'a note aucune difference quant aux taux de fistules pancreatiques postoperatoires, aux retards de la vidange gastrique ou a la mortalite a 90 jours.Conclusion:Ce rapport decrit l'impact de l'integration des systemes de TPN dans la pratique clinique habituelle d'un etablissement achalande. L'utilisation de tels dispositifs apres la pancreatoduodenectomie en presence d'un risque eleve d'IPO n'a pas ete associee a une reduction du taux d'IPO.
C1 [Greene, Brittany] Washington Univ Sch Med St Louis, Div Gen Surg, Sect Hepatobiliary Pancreat & Gastrointestinal Su, Div Gen Internal Med & Endocrinol & Metab, St Louis, MO USA.
   [Lagrotteria, Andrew] Univ Toronto, Temerty Fac Med, Toronto, ON, Canada.
   [Tsang, Melanie E.] Univ Toronto, Temerty Fac Med, Dept Surg, Div Gen Surg, Toronto, ON, Canada.
   [Tsang, Melanie E.; Jayaraman, Shiva] St Josephs Hlth Ctr, Div Gen Surg, Unity Hlth Toronto, Ont can, Toronto, ON, Canada.
   [Jayaraman, Shiva] Unity Hlth Toronto, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Jayaraman, Shiva] Univ Toronto, St Josephs Hlth Ctr HPB Serv, HPB Outpatient Ctr, 1600 Bloor St W, Toronto, ON M6P 1A7, Canada.
C3 Washington University (WUSTL); University of Toronto; University of
   Toronto; University of Toronto; Saint Joseph's Health Centre, Toronto;
   Western University (University of Western Ontario); University Western
   Ontario Hospital; University of Toronto; Li Ka Shing Knowledge
   Institute; University of Toronto
RP Jayaraman, S (通讯作者)，Univ Toronto, St Josephs Hlth Ctr HPB Serv, HPB Outpatient Ctr, 1600 Bloor St W, Toronto, ON M6P 1A7, Canada.
EM shiva.jayaraman@unityhealth.to
OI Jayaraman, Shiva/0009-0004-4487-3521; Tsang, Melanie/0000-0003-3395-9819
CR Andrianello S, 2021, SURGERY, V169, P1069, DOI 10.1016/j.surg.2020.10.029
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NR 19
TC 4
Z9 4
U1 0
U2 2
PU CMA-CANADIAN MEDICAL ASSOC
PI OTTAWA
PA 1867 ALTA VISTA DR, OTTAWA, ONTARIO K1G 5W8, CANADA
SN 0008-428X
EI 1488-2310
J9 CAN J SURG
JI Can. J. Surg.
PY 2023
VL 66
IS 5
BP E507
EP E512
DI 10.1503/cjs.000723
EA DEC 2023
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA W4JW8
UT WOS:001091314000001
PM 37875305
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Demmer, W
   Aranda, IM
   Wiggenhauser, PS
   Braig, D
   Gilbert, F
   Giunta, R
AF Demmer, Wolfram
   Aranda, Irene Mesas
   Wiggenhauser, Paul Severin
   Braig, David
   Gilbert, Fabian
   Giunta, Riccardo
TI Multidrug-resistant bacterial colonisation in Ukrainian war injuries: a
   need for multimodal therapy
SO HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE
LA German
DT Article
DE complex injury; war injuries; free flap; infection; reconstruction of
   the lower limb
AB This case report describes the interdisciplinary treatment of a complex shrapnel injury to the right femur of an 18-year-old Ukrainian soldier. This open multifragmentary fractur of the femur with a large bone defect, soft tissue damage and osteomyelitis was complicated by several multidrug-resistant bacteria, including Acinetobacter baumanii, which could not be eradicated by antibiotic treatment. Sterility was only achieved by multiple radical debridement and by negative pressure wound therapy with instillation (NPWTi) using hypochlorous acid. The femur was then reconstructed with a chimeric double-barrel fibula free flap. This report highlights the importance of multimodal antimicrobial wound treatments in an era of increasing antibiotic resistance to enable a successful und functional reconstruction of complex and infected fractures.
C1 [Demmer, Wolfram; Aranda, Irene Mesas; Wiggenhauser, Paul Severin; Braig, David; Giunta, Riccardo] LMU Munchen, LMU Klinikum, Abt Hand Plast & Asthet Chirurg, Munich, Germany.
   [Gilbert, Fabian] LMU Munchen, LMU Klinikum, Klin Orthopadie & Unfallchirurg, Munich, Germany.
   [Aranda, Irene Mesas] LMU Klinikum Munchen, Abt Hand Plast & Asthet Chirurg, Ziemsenstr 5, D-80336 Munich, Germany.
C3 University of Munich; University of Munich; University of Munich
RP Aranda, IM (通讯作者)，LMU Klinikum Munchen, Abt Hand Plast & Asthet Chirurg, Ziemsenstr 5, D-80336 Munich, Germany.
EM irenemesas.ar97@gmail.com
RI ; Giunta, Riccardo/JVN-5790-2024; Wiggenhauser, Paul/QQY-2593-2026
OI Demmer, Wolfram/0000-0001-7893-3976; 
CR Allen D, 2014, INT WOUND J, V11, P198, DOI 10.1111/j.1742-481X.2012.01073.x
   Chen CJ, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17071161
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   Günther F, 2021, J INFECT PREVENT, V22, P12, DOI 10.1177/1757177420963829
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   TAYLOR GI, 1975, PLAST RECONSTR SURG, V56, P243, DOI 10.1097/00006534-197509000-00001
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   Wang L, 2007, J Burns Wounds, V6, pe5
NR 10
TC 0
Z9 1
U1 0
U2 1
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0722-1819
EI 1439-3980
J9 HANDCHIR MIKROCHIR P
JI Handchir. Mikrochir. Plast. Chir.
PD DEC
PY 2023
VL 55
IS 06
BP 457
EP 461
DI 10.1055/a-2108-8978
EA OCT 2023
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AH4W5
UT WOS:001091383700001
PM 37813349
DA 2026-07-24
ER
PT J
AU Saini, R
   Jeyaraman, M
   Jayakumar, T
   Iyengar, KP
   Jeyaraman, N
   Jain, VK
AF Saini, Ravi
   Jeyaraman, Madhan
   Jayakumar, Tarun
   Iyengar, Karthikeyan P.
   Jeyaraman, Naveen
   Jain, Vijay Kumar
TI Evolving Role of Negative Pressure Wound Therapy with Instillation and
   Dwell Time (NPWTi-d-) in Management of Trauma and Orthopaedic Wounds:
   Mechanism, Applications and Future Perspectives
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Review
DE Negative pressure wound therapy; Granulation tissue; Wound healing;
   NPWT; NPWTi-d-; Instillation
ID SALINE INSTILLATION; FLUID
AB IntroductionNegative Pressure Wound Therapy (NPWT) is a well-established method to promote wound healing by delivering negative pressure (a vacuum) at the wound site. Enhancement of NPWT techniques may allow an innovative way of treating trauma and orthopaedic wounds which provide unique challenges. We explore the role of negative pressure wound therapy with instillation and dwell time (NPWTi-d-) in the management of trauma and orthopaedic wounds.Materials and MethodsA comprehensive search strategy was conducted using databases of PubMed, Web of Science, Google Scholar, and Cochrane Library with the search words of 'NPWTid' or 'NPWTi-d-' or 'NPWT with instillation' or 'Negative pressure wound treatment with instillation' to generate this narrative review. The mechanism of action of NPWTi-d-, installation solutions and current applications in the trauma and orthopaedic wounds is evaluated.ResultsNPWTi-d- provides additional mechanism to promote wound healing in a spectrum of acute and chronic orthopaedic wounds. The technique allows local delivery of hydration and elution of antibiotics to support growth of healthy granulation tissue. Various mechanism of actions contribute in drawing the wound edges together, reduce oedema, help decontamination, deliver local antibiotic and promote healing.ConclusionNPWTi-d- permits an enhanced, supplementary technique to encourage wound healing in challenging traumatic and orthopaedic wounds. Future applications of NPWTi-d- will depend on cost-effectiveness analysis and development of its application guidelines based on longitudinal, randomized controlled research trials.
C1 [Saini, Ravi; Jain, Vijay Kumar] Dr Ram Manohar Lohia Hosp, Atal Bihari Vajpayee Inst Med Sci, Dept Orthopaed, New Delhi, India.
   [Jeyaraman, Madhan; Jeyaraman, Naveen] ACS Med Coll & Hosp, Dr MGR Educ & Res Inst, Dept Orthopaed, Chennai, Tamil Nadu, India.
   [Jayakumar, Tarun] KIMS Sunshine Hosp, Dept Orthopaed, Hyderabad, Telangana, India.
   [Iyengar, Karthikeyan P.] Southport & Ormskirk NHS Trust, Trauma & Orthopaed Surg, Southport PR8 6PN, England.
C3 Dr. M.G.R. Educational & Research Institute
RP Jeyaraman, M (通讯作者)，ACS Med Coll & Hosp, Dr MGR Educ & Res Inst, Dept Orthopaed, Chennai, Tamil Nadu, India.
EM madhanjeyaraman@gmail.com
RI Jain, Vijay/GYJ-5238-2022; Jeyaraman, Madhan/ABB-8464-2020; Iyengar,
   Karthikeyan/S-4529-2019
OI Jain, Vijay/0000-0003-4164-7380; Jayakumar, Tarun/0000-0002-4305-1022;
   Jeyaraman, Madhan/0000-0002-9045-9493; Iyengar,
   Karthikeyan/0000-0002-4379-1266
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NR 49
TC 3
Z9 5
U1 2
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD DEC
PY 2023
VL 57
IS 12
BP 1968
EP 1983
DI 10.1007/s43465-023-01018-x
EA NOV 2023
PG 16
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA AH4Y5
UT WOS:001092137400002
PM 38009182
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Kitano, D
   Sakurai, A
   Kuwazuru, K
   Kitagawa, H
   Taniguchi, T
   Takahara, S
AF Kitano, Daiki
   Sakurai, Atsushi
   Kuwazuru, Kenji
   Kitagawa, Hiroshi
   Taniguchi, Tomoya
   Takahara, Shunsuke
TI Intra-soft tissue and intramedullary antibiotic perfusion in combination
   with negative pressure wound therapy
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE continuous local antibiotic perfusion; gentamicin; intramedullary
   antibiotic perfusion; intra-soft tissue antibiotic perfusion; negative
   pressure wound therapy; wound; wound care; wound dressing; wound healing
ID ANTIMICROBIAL SUSCEPTIBILITY; GENTAMICIN; INFECTION
AB Objective: Intra-soft tissue and intramedullary antibiotic perfusion (iSAP and iMAP), which combine continuous administration of antibiotic solution to the wound and negative pressure wound therapy (NPWT), have been reported to be a useful management approach for hard-to-heal ulcers in the field of orthopaedic surgery. We report the efficacy of this treatment and discuss the key points.
   Method: The recipients of this treatment had contaminated fresh severe trauma with a high risk of infection, or hard-to-heal ulcers which were expected to be difficult to manage with conventional NPWT alone. Continuous administration of 1200 mu g/ml of gentamicin (GM) solution to the wound was performed along with NPWT. The GM solution was administered subcutaneously using a small catheter for iSAP, while intramedullary administration used a bone marrow needle for iMAP.
   Results: iSAP was employed in all 10 patients who took part, and iMAP in three of these patients. The average treatment time was 13.6 days with iSAP and 9.3 days with iMAP. The mean serum GM level during the therapy was 1.02 mu g/ml. Moderate GM-induced acute kidney injury was suspected in one case, but resolved spontaneously after GM administration was stopped. Favourable wound bed preparation was achieved in all cases without recurrence of infection.
   Conclusion: Combination with continuous suction by NPWT is able to keep the local concentration of antibiotic above the minimum inhibitory concentration of biofilm-coated bacteria within the wound. We have referred to this treatment as continuous local antibiotic perfusion. Further investigation of local pharmacodynamics in the wound and side-effects of this treatment are warranted. Declaration of interest: The authors have no conflicts of interest.
C1 [Kitano, Daiki; Sakurai, Atsushi; Kitagawa, Hiroshi; Taniguchi, Tomoya] Hyogo Prefectural Kakogawa Med Ctr, Dept Plast Surg, Kakogawa, Hyogo, Japan.
   [Kitano, Daiki] Kobe Univ, Dept Plast Surg, Grad Sch Med, Kobe, Hyogo, Japan.
   [Kuwazuru, Kenji] Mitsubishi Kobe Hosp, Dept Plast Surg, Kobe, Hyogo, Japan.
   [Takahara, Shunsuke] Hyogo Prefectural Kakogawa Med Ctr, Dept Orthoped Surg, Kakogawa, Hyogo, Japan.
C3 Kobe University
RP Kitano, D (通讯作者)，Hyogo Prefectural Kakogawa Med Ctr, Dept Plast Surg, Kakogawa, Hyogo, Japan.; Kitano, D (通讯作者)，Kobe Univ, Dept Plast Surg, Grad Sch Med, Kobe, Hyogo, Japan.
EM d.kitano.poo@gmail.com
RI Sakurai, Atsushi/W-5167-2019; Kitagawa, Hiroshi/CAJ-3523-2022
CR Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
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NR 30
TC 4
Z9 6
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2023
VL 32
SU 11
BP S14
EP S23
DI 10.12968/jowc.2023.32.Sup11.S14
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA W5XR7
UT WOS:001092359600003
PM 37907367
DA 2026-07-24
ER
PT J
AU Imcha, M
   Liew, NC
   McNally, A
   Zibar, D
   O'Riordan, M
   Currie, A
   Styche, T
   Hughes, J
   Whittall, C
AF Imcha, Mendinaro
   Liew, Nyan Chin
   McNally, Arthur
   Zibar, Davor
   O'Riordan, Mairead
   Currie, Aoife
   Styche, Tim
   Hughes, Jacqui
   Whittall, Catherine
TI Single-use negative pressure wound therapy to prevent surgical site
   complications in high-risk patients undergoing caesarean sections: a
   real-world study
SO INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
LA English
DT Article
DE caesarean section; negative pressure wound therapy; surgical site
   infection; wound-related complications
ID INFECTION
AB Surgical site complications (SSCs), including surgical site infection (SSI), are common following C-sections. Management of the post-operative incision with single-use negative pressure wound therapy (sNPWT) has been shown to reduce the risk of SSC in high-risk individuals. This study explored the outcomes of routine, real-world use of sNPWT in high-risk patients undergoing C-sections.An observational, retrospective in-service evaluation was conducted across eight obstetric centres in the Republic and Northern Ireland. Patients undergoing C-sections were stratified for their risk of developing SSC using commonly known risk factors, including BMI >= 30, smoking, diabetes, and whether the patients had undergone previous C-sections or had a previous history of wound dehiscence. Those at high-risk were treated with sNPWT post-operatively. Data relating to any SSC that developed post-operatively, for up to 30 days, were captured. Data were compared with original research previously published by Wloch et al. (2012).Of 1111 women considered high-risk, 106 (9.5%) went on to develop SSCs, predominantly superficial SSIs. SSCs were associated with extra visits with their general practitioner (GP), outpatient visits, or inpatient hospital stays in 5.7%, 2.4%, and 1.7% of the entire cohort, representing 59.4%, 25.5%, and 17.9% of the 106 patients with SSC. Patients needed on average 1.8 extra GP visits and 0.7 extra outpatient visits. Patients who needed to be readmitted to hospital had an average length of stay of 4 days. In comparison with a previously published cohort, in which sNPWT was not used, we observed a significant reduction in the incidence of SSCs across BMI groups 18.5-24.9 (P = 0.02), 25-29.9 (P = 0.003), and >= 35 kg/m2 (P = 0.04). In those patients who had undergone at least one previous C-section, the rates of complications also reduced (P = 0.006).This analysis provides further justification for using sNPWT to manage surgical incisions in patients considered at high risk of developing post-procedural SSCs, particularly those with a BMI >= 30 or a history of more than one C-section.
C1 [Imcha, Mendinaro; Liew, Nyan Chin] Limerick Univ Matern Hosp, Obstet & Gynaecol, Ennis Rd, Limerick V94 C566, Ireland.
   [McNally, Arthur] Royal Jubilee Matern Hosp, Obstet & Gynaecol, 274 Grosvenor Rd, Belfast BT12 6BA, North Ireland.
   [Zibar, Davor] Univ Coll Hosp Galway, Obstet & Gynaecol, Newcastle Rd, Galway H91 YR71, Ireland.
   [O'Riordan, Mairead] Cork Univ Matern Hosp, Obstet & Gynaecol, Wilton Rd, Cork T12 YE02, Ireland.
   [Currie, Aoife] Craigavon Area Hosp, Obstet & Gynaecol, 68 Lurgan Rd, Craigavon BT63 5QQ, North Ireland.
   [Styche, Tim; Hughes, Jacqui; Whittall, Catherine] Smith & Nephew, Global HEOR, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, England.
C3 Smith & Nephew
RP Whittall, C (通讯作者)，Smith & Nephew, Global HEOR, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, England.
EM Catherine.whittall@smith-nephew.com
RI Whittall, Catherine/AAW-8323-2021
OI Whittall, Catherine/0000-0003-4859-4293; Hughes,
   Jacqui/0000-0003-2413-0654
FU Clinicians, Katherine Ivery, Gemma Ferguson, Lyndsay Creswell (Royal
   Jubilee Maternity Hospital, Belfast, UK), Vineta Ciprike, Etop Akpan,
   Ream Langhe (Our Lady of Lourdes Hospital, Drogheda, Republic of
   Ireland), Geraldine Gaffney, Lorentina Schaeler (Uni; (University
   College Hospital Galway, Galway, Republic of Ireland)
FX Clinicians, Katherine Ivery, Gemma Ferguson, Lyndsay Creswell (Royal
   Jubilee Maternity Hospital, Belfast, UK), Vineta Ciprike, Etop Akpan,
   Ream Langhe (Our Lady of Lourdes Hospital, Drogheda, Republic of
   Ireland), Geraldine Gaffney, Lorentina Schaeler (University College
   Hospital Galway, Galway, Republic of Ireland), Marie Christine De
   Tavernier, Barend Botha (Portiuncula University Hospital, Portincula,
   Republic of Ireland), Heather Langan and Rasha Ibhram (Sligo University
   Hospital, Sligo, Republic of Ireland), provided patient care, data
   collection and staff training in the respective centres, that
   underpinned this evaluation. Editorial services were provided by JMS
   Medical Writing Services Ltd.
CR Anderson V, 2013, MIDWIFERY, V29, P1331, DOI 10.1016/j.midw.2012.12.012
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NR 26
TC 6
Z9 6
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1353-4505
EI 1464-3677
J9 INT J QUAL HEALTH C
JI Int. J. Qual. Health Care
PD OCT 31
PY 2023
VL 35
IS 4
AR mzad089
DI 10.1093/intqhc/mzad089
EA OCT 2023
PG 7
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA W9PI5
UT WOS:001094873800002
PM 37930777
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Casella, D
   Fusario, D
   Pesce, AL
   Marcasciano, M
   Lo Torto, F
   Luridiana, G
   De Luca, A
   Cuomo, R
   Ribuffo, D
AF Casella, Donato
   Fusario, Daniele
   Pesce, Anna Lisa
   Marcasciano, Marco
   Lo Torto, Federico
   Luridiana, Gianluigi
   De Luca, Alessandro
   Cuomo, Roberto
   Ribuffo, Diego
TI Portable Negative Pressure Wound Dressing in Oncoplastic Conservative
   Surgery for Breast Cancer: A Valid Ally
SO MEDICINA-LITHUANIA
LA English
DT Article
DE wound healing; oncoplastic; breast cancer; negative pressure
ID VACUUM-ASSISTED CLOSURE; CONSERVING SURGERY; THERAPY; STANDARDIZATION;
   IMMEDIATE; OUTCOMES; REDUCTION
AB Background and Objectives: The use of oncoplastic techniques has spread widely in the last decade, with an expansion of the indications and demonstration of excellent oncological safety profiles. A potential downside may be the increased complication rates, which could influence the timing of adjuvant therapy. To date, there is increasing evidence that negative pressure therapy on closed wounds can reduce complication rates after surgery. From this perspective, we tested the use of portable negative pressure wound dressings (NPWDs) in oncoplastic surgery to minimize early post-operative admissions to the outpatient clinic and prevent surgical complications. Materials and Methods: An observational prospective cohort study was conducted on a population of patients who underwent quadrantectomy and wise-pattern reduction mammoplasty for breast cancer. The primary objective of the study is represented by the evaluation of the impact of NPWD on post-operative outcomes in an oncoplastic surgery setting. Patients enrolled between January 2021 and January 2023 were divided into two groups, the conventional dressing (CD) group and the NPWD group, by a simple randomization list. Results: A total of 100 patients were enrolled, with 52 in the CD group and 48 in the NPWD group. The use of NPWD significantly reduced the wound dehiscence rate (2.0% vs. 7.7% p = 0.002) and the number of one-month postoperative admissions to our clinic (3.8 +/- 1.1 vs. 5.7 +/- 1.3 p = 0.0009). Although not significant, it is possible to note a trend of reduction of clinically relevant postoperative total complications in patients treated with NPWDs. Conclusions: NPWDs may represent a useful tool in the post-surgical management of complex oncoplastic procedures, ensuring less wound dehiscence. Furthermore, the use of these dressings led to a significant reduction in admissions to the clinic, promoting a lower use of resources by hospitals and effective prevention of possible complications.
C1 [Casella, Donato; Fusario, Daniele; Pesce, Anna Lisa; Cuomo, Roberto] Univ Siena, Dept Med Surg & Neurosci, I-53100 Siena, Italy.
   [Marcasciano, Marco] Univ Catanzaro Magna Graecia, Unit Plast & Reconstruct Surg, I-88100 Catanzaro, Italy.
   [Lo Torto, Federico; Ribuffo, Diego] Sapienza Univ Roma, Dept Plast Reconstruct & Aesthet Surg, I-00185 Rome, Italy.
   [Luridiana, Gianluigi] ARNAS Brotzu, Businco Oncol Hosp, Unit Oncol & Breast Surg, I-09047 Cagliari, Italy.
   [De Luca, Alessandro] Sapienza Univ Roma, Dept Surg, I-00185 Rome, Italy.
C3 University of Siena; Magna Graecia University of Catanzaro; Sapienza
   University Rome; Sapienza University Rome
RP Fusario, D (通讯作者)，Univ Siena, Dept Med Surg & Neurosci, I-53100 Siena, Italy.
EM donato.casella@unisi.it; dani.fusario@gmail.com;
   annalisa.pesce@student.unisi.it; dott.marcomarcasciano@gmail.com;
   federico.lotorto@uniroma1.it; gianluigi.luridiana@aob.it;
   dr.aless.deluca@gmail.com; roberto.cuomo@unisi.it;
   diego.ribuffo@uniroma1.it
RI de luca, alessandro/AAE-5524-2020; Cuomo, Roberto/AFI-8757-2022; Torto,
   Federico/AAY-1852-2021; Marcasciano, Marco/HZJ-0259-2023; Fusario,
   Daniele/ISA-5809-2023; RIBUFFO, Diego/HLG-3305-2023
OI de luca, alessandro/0000-0003-0897-3547; Cuomo,
   Roberto/0000-0002-8396-095X; Fusario, Daniele/0000-0002-2804-2814;
   RIBUFFO, Diego/0000-0002-1844-7850; Casella, Donato/0000-0003-3946-2029
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NR 44
TC 8
Z9 8
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD OCT
PY 2023
VL 59
IS 10
AR 1703
DI 10.3390/medicina59101703
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA X0IN0
UT WOS:001095374900001
PM 37893421
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chen, QL
   Lu, MT
   Liu, XY
   Yu, YM
   Li, JY
AF Chen, Qingling
   Lu, Minting
   Liu, Xueyan
   Yu, Yanmei
   Li, Jiaying
TI Comparison of customized vacuum sealing drainage and vacuum sealing
   drainage in the treatment of diabetic foot ulcers: a retrospective
   analysis
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Diabetic foot ulcers; Vacuum sealing drainage; Customized vacuum sealing
   drainage; Retrospective analysis
ID C-PEPTIDE
AB Background The prevalence of diabetic foot ulcers, a common, more serious chronic diabetes-related complication, is increasing. Vacuum sealing drainage (VSD) constitutes an effective adjunctive treatment for diabetic foot ulcers. Factors, such as poor glycemic control, ischemia, and infection prolong wound healing time, and VSD products are expensive and unaffordable for many patients.ObjectiveTo compare the use of customized VSD and customized VSD in the treatment of diabetic foot ulcer.Method This retrospective study included 83 patients with diabetic foot ulcers in customized VSD (n = 44) and VSD (n = 39) groups. Baseline data, efficacy after 14 days, total treatment efficiency, final outcome (28 days after treatment, healing rate), average treatment cost, and hospitalization (days) of the two groups were compared. Factors affecting wound healing were analyzed.Results No significant intergroup differences in the baseline data were detected (VSD vs. customized VAD, p > 0.05). Treatment efficacy was higher in the customized VSD group than in the VSD group after 14 days (p < 0.05), although total treatment efficiency in both groups reached 100%. The final outcome in the customized VSD group was better (vs. VSD group, p < 0.05), and the wound healing rate was higher than in the VSD group (66.7% vs. 33.3%). The mean treatment cost and hospital days were greater in the VSD group (vs. customized VSD group; p < 0.05). Factors affecting wound healing include age, Wagner classification, HDL-C, and fasting C-peptide. Younger age, low Wagner classification grade, low HDL-C level, and high fasting C-peptide contribute to higher healing rate,Conclusion Efficacy and final outcome of customized VSD were better than that of VSD; the customized VSD device is simple and convenient to operate, and enables cost-effective treatment.
C1 [Chen, Qingling; Li, Jiaying] Jinan Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510632, Peoples R China.
   [Lu, Minting] Jinan Univ, Sch Nursing, Guangzhou 510632, Peoples R China.
   [Liu, Xueyan; Yu, Yanmei] Jinan Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Guangzhou 510632, Peoples R China.
C3 Jinan University; Jinan University; Jinan University
RP Li, JY (通讯作者)，Jinan Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510632, Peoples R China.
EM cqingling0718@163.com
FU This study was supported by the First Hospital Affiliated of Jinan
   University. We are grateful to all the healthcare professionals who
   provided support and assistance in this study.; First Hospital
   Affiliated of Jinan University
FX This study was supported by the First Hospital Affiliated of Jinan
   University. We are grateful to all the healthcare professionals who
   provided support and assistance in this study.
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NR 39
TC 5
Z9 6
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD OCT 27
PY 2023
VL 18
IS 1
AR 803
DI 10.1186/s13018-023-04298-z
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA X1MW3
UT WOS:001096166700001
PM 37891685
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Travis, TE
   Prindeze, NJ
   Shupp, JW
   Sava, JA
AF Travis, Taryn E.
   Prindeze, Nicholas J.
   Shupp, Jeffrey W.
   Sava, Jack A.
TI Intra-abdominal Pressure Monitoring During Negative Pressure Wound
   Therapy in the Open Abdomen
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Damage control laparotomy; Delayed abdominal closure; Negative pressure
   wound therapy; Open abdomen
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; FASCIAL
   CLOSURE; MANAGEMENT; HYPERTENSION; EXPERIENCE; SYSTEMS; WORD; WALL
AB Introduction: Negative pressure wound therapy (NPWT) is commonly used in open abdomen management, where there may be a simultaneous need for prevention of abdominal hypertension, tamponade of hemorrhage, and continuous fascial tension. The regional pressure dynamics of vacuum dressings are poorly understood.
   Methods: Three duroc swine underwent mid-line laparotomy and application of vacuum open abdomen dressing, with and without sponge packing. Twenty-five catheters were placed throughout the abdomen to capture and record pressures in each quadrant as the vacuum system was ranged between (-75 mmHg to -200 mmHg pressure). Vital signs and ventilator pressures were measured and recorded concomitantly.
   Results: No variations in ventilatory pressures or vital signs were observed with any setting. NPWT changed pressure in seven of seventy-five catheters (9%), five of which were related to abdominal packing. When data were grouped into abdominal wall, perihepatic, perisplenic, and deep abdominal regions, there was no significant change in abdominal pressure when packing was absent. With packing, only the abdominal wall region showed a pressure change, reaching a maximum of 20% of the set vacuum pressure.
   Conclusions: NPWT does only little to change the intraabdominal pressure, except in superficial locations in packed abdomens and does not appear to cause hemodynamic changes in a porcine open abdomen model. While NPWT may play an important role in fluid scavenging and fascial tensioning, there are likely to be few benefits or drawbacks specifically related to negative abdominal pressure in the deep abdomen. (c) 2022 Elsevier Inc. All rights reserved.
C1 [Travis, Taryn E.; Prindeze, Nicholas J.; Shupp, Jeffrey W.] MedStar Hlth Res Inst, Firefighters Burn & Surg Res Lab, Washington, DC USA.
   [Travis, Taryn E.; Shupp, Jeffrey W.; Sava, Jack A.] MedStar Washington Hosp Ctr, Dept Surg, Washington, DC USA.
   [Travis, Taryn E.; Prindeze, Nicholas J.; Shupp, Jeffrey W.; Sava, Jack A.] Georgetown Univ, Dept Surg, Sch Med, Washington, DC USA.
C3 MedStar Health Research Institute; MedStar Washington Hospital Center;
   Georgetown University
RP Travis, TE (通讯作者)，MedStar Washington Hosp Ctr, Burn Ctr, 110 Irving St NW,Suite 3B55, Washington, DC 20010 USA.
EM taryn.e.travis@medstar.net
RI Travis, Taryn/AAK-8527-2021; Shupp, Jeffrey/AAW-3481-2021
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NR 26
TC 1
Z9 4
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD OCT
PY 2022
VL 278
BP 100
EP 110
DI 10.1016/j.jss.2022.04.019
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA X2CD1
UT WOS:001096575300004
PM 35597024
DA 2026-07-24
ER
PT J
AU Wu, Y
   Shen, G
   Hao, C
AF Wu, Yin
   Shen, Gan
   Hao, Chao
TI Negative pressure wound therapy (NPWT) is superior to conventional moist
   dressings in wound bed preparation for diabetic foot ulcers
SO SAUDI MEDICAL JOURNAL
LA English
DT Article
DE diabetic foot ulcers; wound blood perfusion; negative pressure wound
   therapy; neutrophil extracellular traps; macrophages polarization
ID SKIN-GRAFT
AB Objectives: To compare the efficacy of negative pressure wound therapy (NPWT) and alginate dressings on wound bed preparation prior to split thickness skin graft (STSG) surgery for patients with chronic diabetic foot ulcers (DFUs). Methods: Between September 2022 and March 2023, we completed a randomized controlled trial in Nanjing First Hospital and PLA 454 Hospital. Patients were divided into 2 groups: i) the NPWT group (with vacuum-assisted closure, n=50); ii) the control group (with alginates dressings, n=50). Once DFU wound was filled with healthy granulation tissues, STSG surgery was performed. The time to STSG surgery was regarded as the primary outcome. The survival rates of skin graft, the wound blood perfusion, the wound neutrophil extracellular traps (NETs) formation, and polarization of M1 and M2 macrophages in DFU wounds were regarded ad secondary outcomes. Results: Patients in the NPWT group had less time to STSG surgery than the control group. The patients in the NPWT group had prominently increased survival rates of skin graft, increased wound blood perfusion, and decreased NET formation in comparison with the control group. The macrophages in DFU wounds switched from M1 to M2 phenotype in the NPWT group. Conclusion: Negative pressure wound therapy is superior to conventional moist dressings in wound bed preparation prior to STSG surgery for patients with chronic DFUs.
C1 [Wu, Yin; Shen, Gan; Hao, Chao] Nanjing Med Univ, Nanjing Hosp 1, Dept Burn & Plast Surg, Nanjing, Peoples R China.
C3 Nanjing Medical University
RP Wu, Y (通讯作者)，Nanjing Med Univ, Nanjing Hosp 1, Dept Burn & Plast Surg, Nanjing, Peoples R China.
EM wuyinnjyy06@163.com
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NR 30
TC 32
Z9 36
U1 6
U2 26
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
EI 1658-3175
J9 SAUDI MED J
JI Saudi Med. J.
PD OCT 1
PY 2023
VL 44
IS 10
BP 1020
EP 1029
DI 10.15537/smj.2023.44.20230386
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA X3UV1
UT WOS:001097747200009
PM 37777272
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lin, ZY
   Zhang, XL
   Chen, YJ
   Tian, Y
   Yang, X
   Zhao, ZM
AF Lin, Zhiyu
   Zhang, Xinling
   Chen, Yujie
   Tian, Yun
   Yang, Xin
   Zhao, Zhenmin
TI Negative pressure wound therapy for flap closed-incisions after
   3D-printed prosthesis implantation in patients with chronic
   osteomyelitis with soft tissue defects
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Chronic osteomyelitis; Closed-incision; Negative pressure wound therapy;
   Soft tissue defects
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; SURGERY; INFECTIONS; PERFUSION
AB BackgroundThe flap closed-incisions healing after 3D-printed prosthesis implantation in Chronic Osteomyelitis with Soft Tissue Defects (COSTD) is critical. This study aimed to explore the safety and effectiveness of Negative Pressure Wound Therapy (NPWT) in promoting flap closed-incisions healing.MethodsRetrospective analysis of clinical data was performed, including baseline, surgical and hospitalization information. The efficacy of NPWT was assessed by comparing the ASEPSIS scores, Visual Analogue Scale (VAS), Activity of Daily Living Scale (ADLS), and Lower Extremity Functional Scale (LEFS), as well as the major postoperative complications.ResultsThe study included 20 patients, 13 received conventional dressing (Control group) and 7 received NPWT treatment (NPWT group). These two groups exhibited a notable disparity in the distribution of ASEPSIS scores, and the median scores were 24 in Control group and 9 in NPWT group (p = 0.001). Eight patients in the Control group experienced major incisional complications, including 7 cases of exudation, 3 cases of infection, 2 cases of non-healing, and 1 case of dehiscence, while none were observed in the NPWT group (p = 0.015). The VAS, ADLS, and LEFS scores were significantly improved in the NPWT group compared to the Control group (p = 0.003, 0.017, and 0.043, respectively).ConclusionsThe study findings suggest that NPWT applied to the healing process of flap closed-incisions after 3D prosthesis implantation in patients with COSTD can reduce the occurrence of postoperative major complications and promote the recovery of lower limb function and daily activities, which should be recommended for clinical practice.
C1 [Lin, Zhiyu; Chen, Yujie; Yang, Xin; Zhao, Zhenmin] Peking Univ Third Hosp, Dept Plast Surg, 49 North Garden Rd, Beijing 100191, Peoples R China.
   [Zhang, Xinling] Beijing Hosp, Dept Plast Surg, Beijing, Peoples R China.
   [Tian, Yun] Peking Univ Third Hosp, Dept Orthopaed, 49 North Garden Rd, Beijing 100191, Peoples R China.
C3 Peking University; Beijing Hospital; Peking University
RP Yang, X; Zhao, ZM (通讯作者)，Peking Univ Third Hosp, Dept Plast Surg, 49 North Garden Rd, Beijing 100191, Peoples R China.
EM yangxin6@126.com; zzmbysy@sina.com
RI Tian, Yun/PHA-5748-2026; Zhao, Zhenmin/NCV-1162-2025
FU Not applicable.
FX Not applicable.
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NR 35
TC 6
Z9 6
U1 1
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD OCT 19
PY 2023
VL 24
IS 1
AR 827
DI 10.1186/s12891-023-06970-1
PG 11
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA X6ED8
UT WOS:001099353600002
PM 37858142
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tang, Y
   Liu, L
   Jie, RY
   Tang, YZ
   Zhao, XT
   Xu, MR
   Chen, MW
AF Tang, Ying
   Liu, Lei
   Jie, Ruyan
   Tang, Yizhong
   Zhao, Xiaotong
   Xu, Murong
   Chen, Mingwei
TI Negative pressure wound therapy promotes wound healing of diabetic foot
   ulcers by up-regulating PRDX2 in wound margin tissue
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; SKIN
AB To understand the changes in the peroxiredoxin-2 (PRDX2) expression level in the wound margin tissue (T-PRDX2) of patients with diabetic foot ulcer (DFU) before and after negative pressure wound therapy (NPWT). Additionally, the study aimed to explore the association between PRDX2 expression and the treatment outcome of DFUs to provide a new theoretical basis for revealing the mechanism of NPWT promoting the healing of DFUs. Fifty-six type 2 diabetes patients with foot ulcers undergoing NPWT (the DFU group) and 28 patients with chronic lower limb skin ulcers with normal glucose tolerance undergoing NPWT (the skin ulcer control [SUC] group) were included in the study. T-PRDX2 was detected using Western blotting, and the superoxide dismutase (SOD) activity and the malondialdehyde (MDA) and glutathione (GSH) levels were detected using a biochemical method. In addition, in vitro experiments were conducted to determine the effect of PRDX2 expression on normal human dermal fibroblast (NHDF) proliferation, migration, and apoptosis. Before NPWT, the DFU group exhibited a significantly lower T-PRDX2 expression level compared with the SUC group. After one week of NPWT, the T-PRDX2 expression level, SOD activity, and GSH content in the wound margin tissues of the DFU and SUC groups significantly increased compared with the before NPWT levels. Conversely, the inflammatory indicators (white blood cell, neutrophil percentage, C-reactive protein, and procalcitonin) and MDA content were significantly lower than the before NPWT levels. The expression changes of T-PRDX2 before and after NPWT in the DFU and SUC groups were positively correlated with the 4-week wound healing rate. In vitro experiments demonstrated that PRDX2 could alleviate the oxidative stress in NHDFs, thereby promoting their proliferation and migration, while reducing cell apoptosis. NPWT promotes DFU healing by increasing T-PRDX2, and changes in the T-PRDX2 might be associated with the therapeutic effect of NPWT.
C1 [Tang, Ying; Liu, Lei; Jie, Ruyan; Zhao, Xiaotong; Xu, Murong; Chen, Mingwei] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei, Anhui, Peoples R China.
   [Tang, Yizhong] Anhui Med Univ, Affiliated Hosp 1, Dept Burns, Hefei, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Xu, MR; Chen, MW (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei, Anhui, Peoples R China.
EM crystally@foxmail.com; chmw1@163.com
RI ; Xu, Murong/HHS-2387-2022; CHEN, MINGWEI/KHT-6744-2024
OI Liu, Lei/0000-0002-4725-7941; 
FU We are grateful to the all patients for participating in the study. We
   thank the participants of this study including the doctors, nurses, and
   researchers from the Department of Endocrinology in the First Affiliated
   Hospital of Anhui Medical University.; Department of Endocrinology in
   the First Affiliated Hospital of Anhui Medical University
FX We are grateful to the all patients for participating in the study. We
   thank the participants of this study including the doctors, nurses, and
   researchers from the Department of Endocrinology in the First Affiliated
   Hospital of Anhui Medical University.
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NR 50
TC 11
Z9 15
U1 0
U2 22
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 27
PY 2023
VL 13
IS 1
AR 16192
DI 10.1038/s41598-023-42634-9
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA X7AX4
UT WOS:001099946000102
PM 37758743
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Huang, GS
   Xu, KC
AF Huang, Gao-Shi
   Xu, Ke-Chen
TI Application of negative pressure wound therapy after skin grafting in
   the treatment of skin cancer: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Skin cancer; Negative pressure wound therapy; Skin grafting; Case report
AB BACKGROUNDSkin cancer is a common malignant tumor in dermatology. A large area must be excised to ensure a negative incisal margin on huge frontotemporal skin cancer, and it is difficult to treat the wound. In the past, treatment with skin grafting and pressure dressing was easy to cause complications such as wound infections, subcutaneous effusion, skin necrosis, and contracture. Negative pressure wound therapy (NPWT) has been applied to treat huge frontotemporal skin cancer.CASE SUMMARYHerein, we report the case of a 92-year-old woman with huge frontotemporal skin cancer. The patient presented to the surgery department complaining of ruptured bleeding and pain in a right frontal mass. The tumor was pathologically diagnosed as highly differentiated squamous cell carcinoma. The patient underwent skin cancer surgery and skin grafting, after which NPWT was used. She did not experience a relapse during the three-year follow-up period.CONCLUSIONNPWT is of great clinical value in the postoperative treatment of skin cancer. It is not only inexpensive but also can effectively reduce the risk of surgical effusion, infection, and flap necrosis.
C1 [Huang, Gao-Shi] Wuyi First Peoples Hosp, Dept Surg, Wuyi 321200, Zhejiang, Peoples R China.
   [Xu, Ke-Chen] Wuyi First Peoples Hosp, Clin Lab, 2 Nanmen St, Wuyi 321200, Zhejiang, Peoples R China.
RP Xu, KC (通讯作者)，Wuyi First Peoples Hosp, Clin Lab, 2 Nanmen St, Wuyi 321200, Zhejiang, Peoples R China.
EM 8015059@zju.edu.cn
RI Xu, Kechen/MGB-6985-2025
OI Xu, Kechen/0000-0001-5634-2534
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NR 10
TC 0
Z9 0
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD OCT 6
PY 2023
VL 11
IS 28
BP 6812
EP 6816
DI 10.12998/wjcc.v11.i28.6812
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA X9CR9
UT WOS:001101354800017
PM 37901026
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yu, ZZ
   Jin, SY
   Zang, MQ
   Zhu, S
   Li, SS
   Han, TL
   Chen, ZX
   Liu, YB
AF Yu, Zouzou
   Jin, Shengyang
   Zang, Mengqing
   Zhu, Shan
   Li, Shanshan
   Han, Tinglu
   Chen, Zixiang
   Liu, Yuanbo
TI Successful Reconstruction of Complex Sacrococcygeal Defects Using
   Chimeric Perforator Propeller Flap
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE complex defect; reconstruction; sacrococcygeal region; chimeric
   perforator propeller flap; superior gluteal artery
ID SOFT-TISSUE RECONSTRUCTION; Y ADVANCEMENT FLAP; TOTAL SACRECTOMY; SACRAL
   TUMORS; MUSCLE FLAP; MANAGEMENT; RESECTION; INFECTIONS
AB BackgroundComplex soft tissue defects, which result from the surgical resection of sacral tumors, manifest as a combination of skin defects, dead space, infection, and prosthesis exposure. Because the traditional musculocutaneous flap lacks flexibility because of the close connection between the skin flap and the muscle component, the musculocutaneous flap is not suitable for reconstructing complex soft tissue defects where the dead space and skin defects are located at different sites. Furthermore, the perforator flap is also not appropriate for reconstructing complex defects because it lacks the muscular component. We considered the possibility of using the chimeric perforator propeller flap for reconstructing complex sacrococcygeal defects.MethodsThis study included 7 patients who underwent, between July 2007 and July 2021, the reconstruction of complex soft tissue defects of the sacrococcygeal region using a chimeric perforator propeller flap.ResultsAmong the included cases, the etiologies were chordoma (n = 3), sacral tumor (n = 3), and squamous cell carcinoma (n = 1). In all the cases, vacuum-assisted closure therapy was used to treat wound infections before surgery. The average sizes of the skin and muscle flaps were 195.8 cm2 (range, 100-350 cm2) and 83.6 cm2 (range, 60-140 cm2), respectively. The superior gluteal artery was the source artery for the chimeric perforator propeller flap. The donor sites were primarily closed in all cases. One patient had delayed wound healing, and the secondary wound healed using conservative dressing changes. The other 6 flaps had no complications. The average follow-up time was 5.3 months (range, 1-9 months). Muscle weakness and compromised ambulation in the affected lower extremities were not observed in any of the patients. Furthermore, all 7 patients had no tumor recurrence, prosthesis exposure, and infection events in the sacrococcygeal region.ConclusionsThe chimeric perforator propeller flap may be an option for reconstructing complex soft tissue defects in the sacrococcygeal region.
C1 [Yu, Zouzou; Jin, Shengyang; Zang, Mengqing; Zhu, Shan; Li, Shanshan; Han, Tinglu; Chen, Zixiang; Liu, Yuanbo] Chinese Acad Med Sci, Peking Union Med Coll, Plast Surg Hosp, Dept Plast & Reconstruct Surg, 33 Ba Da Chu Rd, Beijing 100144, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Plastic Surgery Hospital - CAMS; Peking Union Medical College
RP Liu, YB (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll, Plast Surg Hosp, Dept Plast & Reconstruct Surg, 33 Ba Da Chu Rd, Beijing 100144, Peoples R China.
EM pumcyu@126.com; 1181130880@qq.com; zangmengqing@sina.com; tddzs@tom.com;
   lishanshan0308@126.com; yatouhaizhiyun2013@163.com;
   chenzixiangcc@163.com; ybpumc@sina.com
RI Chen, Zixiang/IZP-9251-2023; Zang, Mengqing/JJD-4306-2023; li,
   shanshan/ABD-5803-2021; jin, shengyang/PLC-3075-2026
OI Jin, Shengyang/0009-0003-0837-0882; 
FU Capital's Funds for Health Improvement and Research [2022-1-4041]
FX This study was supported by the Capital's Funds for Health Improvement
   and Research (grant/award number 2022-1-4041).
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TC 0
Z9 1
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD NOV
PY 2023
VL 91
IS 5
BP 597
EP 603
DI 10.1097/SAP.0000000000003698
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA Y4KT0
UT WOS:001104974100010
PM 37823625
DA 2026-07-24
ER
PT J
AU Wang, HQ
   Sun, SN
   Wang, GH
   Huang, QB
   Zhang, ZL
AF Wang, Huaqing
   Sun, Shengnan
   Wang, Guanghui
   Huang, Qibing
   Zhang, Zeli
TI Analysis of Vacuum-Assisted Closure-Assisted Antibiotic Irrigation in
   Treatment of Severe Neurosurgical Central Nervous System Infections
SO SURGICAL INFECTIONS
LA English
DT Article
DE antibiotic irrigation; debridement; outcomes; severe neurosurgical
   central nervous system infections; vacuum-assisted closure
ID DERMAL REGENERATION TEMPLATE; WOUND THERAPY; SCALP; RECONSTRUCTION;
   VENTRICULITIS
AB Objective: Severe neurosurgical central nervous system infections (sNCNSIs) are among the most serious complications of neurosurgical disease. Conventional methods have shown a poor prognosis. This study aims to analyze the clinical characteristics of vacuum-assisted closure (VAC) in sNCNSIs with the help of antibiotic irrigation treatment.Patients and Methods: A retrospective study was performed for patients diagnosed with sNCNSIs. A VAC device was placed on the incision after debridement and the surgical cavity was rinsed with antibiotic agents in the VAC group. Meanwhile the surgical cavity was drained after debridement in the control group. Medical data were reviewed and analyzed.Results: Twenty-eight patients met the inclusion criteria, including 18 cases in the VAC group and 10 cases in the control group. The basic medical data showed no differences. Bacteria was isolated from 24 (85.7%) patients. The cure rate was significantly higher in the VAC group (p < 0.05). The cure rate in patients with multi-drug-resistant (MDR) infections was significantly higher in patients treated with VAC therapy (p < 0.05). The prognosis evaluated by Glasgow Outcome Score (GOS) between the two groups showed significant difference (p < 0.05). No re-infection in the VAC group occurred in the follow-up period.Conclusions: It is suggested that VAC-assisted antibiotic irrigation is safe and effective for patients with severe NCNSIs and can improve the prognosis dramatically. The results can provide a new effective and reasonable therapeutic strategy for patients with sNCNSIs.
C1 [Wang, Huaqing; Wang, Guanghui; Huang, Qibing; Zhang, Zeli] Shandong Univ, Qilu Hosp, Dept Emergency, Neurosurg Intens Care Unit, Jinan, Shandong, Peoples R China.
   [Wang, Huaqing; Wang, Guanghui; Huang, Qibing; Zhang, Zeli] Shandong Univ, Brain Sci Res Inst, Jinan, Shandong, Peoples R China.
   [Sun, Shengnan] Shandong Med Coll, Dept Nursing, Jinan, Shandong, Peoples R China.
C3 Shandong University; Shandong University
RP Huang, QB; Zhang, ZL (通讯作者)，Shandong Univ, Qilu Hosp, Dept Emergency, Neurosurg Intens Care Unit, Jinan, Shandong, Peoples R China.; Huang, QB; Zhang, ZL (通讯作者)，Shandong Univ, Brain Sci Res Inst, Jinan, Shandong, Peoples R China.
EM qibingqilu@126.com; zelishandong@126.com
RI Wang, Guanghui/GWC-6635-2022
FU National Natural Science Foundation of China [82171362]; Natural Science
   Foundation of Shandong Province [ZR2021MH366]
FX This study was supported by National Natural Science Foundation of China
   (grant no. 82171362) and Natural Science Foundation of Shandong Province
   (grant no.ZR2021MH366)
CR Ahmed Osama, 2015, Surg Neurol Int, V6, P11, DOI [10.4103/2152-7806.149846, 10.4103/2152-7806.149846]
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   Subotic U, 2011, NEUROSURGERY, V68, pE1481, DOI 10.1227/NEU.0b013e318210c7fb
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD NOV 1
PY 2023
VL 24
IS 9
BP 803
EP 810
DI 10.1089/sur.2023.129
PG 8
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA Z2CA4
UT WOS:001110198000013
PM 37910866
DA 2026-07-24
ER
PT J
AU Ma, XY
   Yuan, H
   Cui, D
   Liu, B
   Han, TY
   Yu, HL
   Zhou, DP
AF Ma, Xiang-Yu
   Yuan, Hong
   Cui, Dong
   Liu, Bing
   Han, Tian-Yu
   Yu, Hai-Long
   Zhou, Da-Peng
TI Management of segmental defects post open distal femur fracture using a
   titanium cage combined with the Masquelet technique A single-centre
   report of 23 cases
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Masquelet technique; Open fractures; Distal femur; Segmental bone
   defects; Titanium cage
ID PLATE OSTEOSYNTHESIS MIPO; CANCELLOUS BONE-GRAFT; MESH CAGE; LOCKING
   PLATE; TRANSPORT; RECONSTRUCTION
AB Introduction: The segmental bone defects post open distal femur fracture presents a reconstructive challenge, which often requires extreme solutions. The present study reviewed a new treatment strategy which used a cylindrical titanium mesh cage as an adjunct to the Masquelet technique. Methods: We retrospectively reviewed a consecutive series of 23 patients treated for segmental bone defects post open distal femur fracture using a titanium mesh cage combined with the Masquelet technique under a 2-staged protocol in our institution from 2017 to 2021. The study group consisted of 13 men and 10 women with an average age of 44.1 years. The surgical debridement was performed with antibiotic polymethylmethacrylate (PMMA) cement spacer implanted into the bone defect combined with cement-wrapped plate stabilization, or antibiotic beads with vacuum sealing drainage (VSD) to cover the wound. The second stage of the Masquelet technique for bone defect repair began at least 4-6 weeks after the first stage, once all signs of possible infection were eliminated. After the cement spacer was removed, the definitive reconstruction was completed with ex-change to a cylindrical titanium mesh cage filled with cancellous autograft within the induced membrane. The bone defect with cage was stabilized with a distal femoral Less Invasive Stabilization System (LISS). The radiological and clinical records of the enrolled patients were retrospectively analyzed. Results: The mean follow-up was 38.6 months. The average number of operations before the second stage was 1.3. The mean interval between the two stages was 12.7 weeks. The average length of the defect measured 8.3 cm (ranging from 6.1 to 12.4 cm). All the defects filled with autograft within the cage achieved bony union, with a mean healing time of 8.4 months. At the latest follow-up, the mean knee extension measured 6.2 degrees (ranging from 0 degrees to 20 degrees), and the mean flexion measured 101.8 degrees (ranging from 60 degrees to 120 degrees). Complications included two in-stances of superficial stitch abscess, which eventually healed. Conclusions: The use of a titanium cage implanted into an induced membrane in a 2-staged Masquelet protocol could achieve satisfactory clinical outcomes in cases of segmental defects following open distal femur fractures.
C1 [Ma, Xiang-Yu; Yuan, Hong; Liu, Bing; Han, Tian-Yu; Yu, Hai-Long; Zhou, Da-Peng] Gen Hosp Northern Theatre Command, Dept Orthoped, Shenyang 110016, Liaoning, Peoples R China.
   [Cui, Dong] 967 Hosp PLA Joint Logist Support Force, Dept Cardiol, Dalian 116011, Liaoning, Peoples R China.
RP Zhou, DP (通讯作者)，Gen Hosp Northern Theatre Command, Dept Orthoped, Shenyang 110016, Liaoning, Peoples R China.
EM me3210@163.com
OI Dapeng, Zhou/0000-0001-7455-5699
FU Liaoning Province Natural Science Foundation of China [2021-MS-038,
   2021JH2/10300057]; Shenyang Municipal Science and Technology Foundation
   [22-321-32-07]
FX This work was supported by the grant from Liaoning Province Natural
   Science Foundation of China (No. 2021-MS-038) to Xiang-Yu Ma, Liaoning
   Province Natural Science Foundation of China (No. 2021JH2/10300057) to
   Da-Peng Zhou, and Shenyang Municipal Science and Technology Foundation
   (No. 22-321-32-07) to Da-Peng Zhou.
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NR 59
TC 6
Z9 6
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD DEC
PY 2023
VL 54
IS 12
AR 111130
DI 10.1016/j.injury.2023.111130
EA OCT 2023
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA Z2OW3
UT WOS:001110531900001
PM 37890289
DA 2026-07-24
ER
PT J
AU Fernández, LG
AF Fernandez, Luis G.
TI Treatment of Complex Thoracic and Abdominal Trauma Patients: A Review of
   Literature and Negative Pressure Wound Therapy Treatment Options
SO ADVANCES IN WOUND CARE
LA English
DT Review
DE trauma; negative pressure wound therapy; negative pressure wound therapy
   with instillation; closed incision negative pressure therapy; open
   abdomen negative pressure therapy; review
ID DAMAGE CONTROL SURGERY; OPEN ABDOMEN; MANAGEMENT; INSTILLATION; CLOSURE;
   RECOMMENDATIONS; INFECTIONS; FRACTURES; INJURIES; OUTCOMES
AB Significance: In trauma care, extensive surgical intervention may be required. Damage control surgery (DCS) is applicable to patients with life or limb-threatening conditions that are incapable of tolerating a traditional surgical approach.Recent Advances: The current resuscitation strategy for complex trauma patients includes limiting crystalloid fluids, balanced mass transfusion protocols, permissive hypotension, and damage control resuscitation. Recent technological advancements in surgical critical care have improved outcomes in these critically ill patients.Critical Issues: DCS, which is often required in patients with trauma injuries, is typically followed by surgical correction of the injury once the immediate patient survival procedures have been completed. However, DCS and the subsequent injury repair procedures have a high risk for postsurgical complication development.Future Directions: Negative pressure therapy modalities can offer clinicians additional adjunctive and cost-effective tools for the management of the trauma care patient, as these systems can be utilized during both the DCS and the postoperative injury management phases of trauma care.
C1 [Fernandez, Luis G.] Univ Texas Hlth Sci Ctr, Dept Surg, Div Trauma Surg Surg Crit Care, Tyler, TX 75708 USA.
   [Fernandez, Luis G.] Univ Texas Tyler, Sch Med, Bill Barrett Endowed Chair Trauma Surg, Tyler, TX 75799 USA.
C3 University of Texas System; University of Texas-Health Sciences Center
   at Tyler (UTHSCT); University of Texas at Tyler; University of Texas
   System; University of Texas at Tyler
RP Fernández, LG (通讯作者)，Univ Texas Hlth Sci Ctr, Dept Surg, Div Trauma Surg Surg Crit Care, Tyler, TX 75708 USA.; Fernández, LG (通讯作者)，Univ Texas Tyler, Sch Med, Bill Barrett Endowed Chair Trauma Surg, Tyler, TX 75799 USA.
EM thebigkahuna115@gmail.com
RI FERNANDEZ, LUIS/O-7657-2019
OI FERNANDEZ, LUIS/0000-0002-2730-0199
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NR 49
TC 4
Z9 7
U1 1
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD AUG 1
PY 2024
VL 13
IS 8
BP 416
EP 423
DI 10.1089/wound.2023.0113
EA OCT 2023
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA A7O0L
UT WOS:001110684700001
PM 37672527
OA hybrid
DA 2026-07-24
ER
PT J
AU Stucke, C
   Reeves, L
   Haycock, D
AF Stucke, Christopher
   Reeves, Lance
   Haycock, Darryl
TI An Innovative Approach to Calcaneal Decubitus Ulcerations Through
   Calcaneal Decorticalization with Use of Localized Bone Marrow and
   Negative-Pressure Wound Therapy A Case Study
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID HEEL; MANAGEMENT; ALGORITHM
AB Heel decubitus ulcerations are relatively common occurrences that can be limb threatening. There are many options to treat these ulcerations, ranging from conservative wound care to serial debridement with flap reconstruction. However, not all patients are good candidates for major reconstructive surgery. In this case, we present a 46-year-old man who failed 3 months of conservative wound care after sustaining a heel decubitus ulcer because of immobilization from a motor vehicle accident. The ulceration was treated with sharp excision of the wound with calcaneal decorticalization and use of negative-pressure wound therapy to use the localized bone marrow within the wound bed. The patient went on to heal within 3 months of operative intervention and remains healed greater than 1 year postoperatively. This technique provided the ability to use localized bone marrow to assist in wound healing without the operative morbidity of a reconstructive procedure. (J Am Podiatr Med Assoc 112(2), 2022)
C1 [Stucke, Christopher; Reeves, Lance] Mercy Hlth St Ritas Med Ctr, Lima, OH USA.
   [Reeves, Lance] West Cent Ohio Podiatry, Lima, OH USA.
   [Stucke, Christopher] Grand Lake Foot & Ankle Ctr, St Marys, OH USA.
   [Haycock, Darryl] Haycock Foot & Ankle Ctr, Lima, OH USA.
   [Reeves, Lance] West Cent Ohio Podiatry, 1138 High St, Lima, OH 45805 USA.
RP Reeves, L (通讯作者)，West Cent Ohio Podiatry, 1138 High St, Lima, OH 45805 USA.
EM Lancereeves13@gmail.com
CR Badiavas EV, 2003, ARCH DERMATOL, V139, P510, DOI 10.1001/archderm.139.4.510
   Bingol UA, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/785819
   Boffeli TJ, 2013, J FOOT ANKLE SURG, V52, P107, DOI 10.1053/j.jfas.2012.06.018
   Boyko TV, 2018, ADV WOUND CARE, V7, P57, DOI 10.1089/wound.2016.0697
   Brucato MP, 2019, J FOOT ANKLE SURG, V58, P591, DOI 10.1053/j.jfas.2018.09.016
   Chittoria RK, 2016, ADV WOUND CARE, V5, P102, DOI 10.1089/wound.2014.0612
   Edsberg LE, 2016, J WOUND OSTOMY CONT, V43, P585, DOI 10.1097/WON.0000000000000281
   El-Shazly M, 2008, J FOOT ANKLE SURG, V47, P145, DOI 10.1053/j.jfas.2007.12.010
   Elmarsafi T, 2019, J FOOT ANKLE SURG, V58, P381, DOI 10.1053/j.jfas.2018.08.040
   Goudie EB, 2012, INT WOUND J, V9, P132, DOI 10.1111/j.1742-481X.2011.00869.x
   JIANG X, 2016, Medicine, V95, P1
   Noble-Bell G, 2008, INT WOUND J, V5, P233, DOI 10.1111/j.1742-481X.2008.00430.x
   Oliver NG, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/432164
NR 13
TC 0
Z9 0
U1 0
U2 0
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD MAR-APR
PY 2022
VL 112
IS 2
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA Z4SB4
UT WOS:001111980300005
DA 2026-07-24
ER
PT J
AU Ueda, M
   Makoto, O
   Sakai, A
AF Ueda, Misato
   Makoto, Omori
   Sakai, Ayumi
TI Use of a Skin-Covering Pocket as a Local Flap and Negative Pressure
   Wound Therapy with Instillation and Dwell Time/Negative Pressure Wound
   Therapy for the Treatment of Diabetic Foot Ulcer with Calcaneal
   Osteomyelitis
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID RECONSTRUCTION
AB For diabetic foot ulcers with "pockets" (wound edge undermining), a surgical incision to the undermining space and debridement are required primarily. Osteomyelitis should be treated if present. Furthermore, it is necessary for the foot to be able to withstand load after control-ling the infection and necrosis. We report a case of a patient treated with a skin-covering pocket as a local flap and negative pressure wound therapy with instillation and dwell time and negative pressure wound therapy to relieve osteomyelitis and promote wound contraction. There was no involvement of other body parts, and only the pocket consisting of skin at the sole of the foot was used, and load could be withstood.
C1 [Ueda, Misato; Makoto, Omori; Sakai, Ayumi] Yodogawa Christians Hosp, Dept Plast Surg, Osaka, Japan.
   [Ueda, Misato] Yodogawa Christians Hosp, Dept Plast Surg, 1-7-50 Kunijima,Higashiyodogawa Ku,, Osaka 5330024, Japan.
RP Ueda, M (通讯作者)，Yodogawa Christians Hosp, Dept Plast Surg, 1-7-50 Kunijima,Higashiyodogawa Ku,, Osaka 5330024, Japan.
EM sakuramochi0v0@yahoo.co.jp
CR BERMAN SS, 1994, AM J SURG, V167, P435, DOI 10.1016/0002-9610(94)90130-9
   Crowe CS, 2019, PLAST RECONSTR SURG, V143, P1223, DOI 10.1097/PRS.0000000000005448
   EDGARDO RC, 2017, Clin Surg, V2, P1632
   EID A, 2012, ISRN Orthop, V2012
   Faust E, 2021, PLAST RECONSTR SURG, V147, p16S, DOI 10.1097/PRS.0000000000007607
   Hasenstein TA, 2019, CLIN PODIATR MED SUR, V36, P425, DOI 10.1016/j.cpm.2019.02.006
   HIROKAZU T, 2017, J Jpn P.R.S., V37, P117
   Leffler M, 2009, INFECTION, V37, P24
   Murray HJ, 1996, DIABETIC MED, V13, P979, DOI 10.1002/(SICI)1096-9136(199611)13:11<979::AID-DIA267>3.3.CO;2-1
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   Oh SJ, 2011, J PLAST RECONSTR AES, V64, P248, DOI 10.1016/j.bjps.2010.04.013
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   Wilhelmi BJ, 1998, ANN PLAS SURG, V41, P215, DOI 10.1097/00000637-199808000-00019
NR 14
TC 2
Z9 2
U1 0
U2 0
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD SEP-OCT
PY 2023
VL 113
IS 5
AR 061
DI 10.7547/21-061
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA Z4SW7
UT WOS:001112001800014
PM 37938898
DA 2026-07-24
ER
PT J
AU Davis, KE
   Bills, J
   Noble, D
   Crisologo, PA
   Lavery, LA
AF Davis, Kathryn E.
   Bills, Jessica
   Noble, Debby
   Crisologo, Peter A.
   Lavery, Lawrence A.
TI Ultraviolet-A Light and Negative-Pressure Wound Therapy to Accelerate
   Wound Healing and Reduce Bacterial Proliferation
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; CONTROLLED-TRIAL;
   MANAGEMENT; IRRADIATION; MULTICENTER; PREVALENCE; AMPUTATION; DISEASE;
   KIDNEY
AB Background: Ultraviolet (UV)-A therapy is a simple, inexpensive, and effective modality for wound healing, with tremendous potential to improve healing and reduce clinical infections in a number of clinical settings. To date, application of UV-A relies on bulky and hard -to-dose lamps that provide inconsistent therapy, thus making it difficult to apply therapy that is appropriate for the patient.Methods: This study was designed to test the effectiveness of a novel wound therapy de -vice that combines UV-A with traditional negative-pressure wound therapy (NPWT) to pro -mote wound healing. Furthermore, we tested the ability of fiberoptic UV-A delivery to inhibit bacterial proliferation. Finally, we assayed the level of DNA damage that results from UV-A as compared to established UV-C therapies. Wound healing studies were performed in a porcine model using an articulated therapy arm that allows for continued therapy administra-tion over an extended time course. Negative-pressure wound therapy was administered alone or with UV-A fiberoptic therapy for 2 weeks. Dressings were changed twice a week, at which time wound area was assessed.Results: Data demonstrate that UV-A with NPWT treatment of wounds results in greater healing than NPWT alone. Using the same therapy device, we demonstrate that exposure of Staphylococcus aureus and Pseudomonas aeruginosa to fiberoptic UV-A results in decreased colony area and number of both bacterial strains. Finally, we show that UV-A induces minimal DNA damage in human fibroblasts and no more DNA damage in wound tis-sue as compare to intact skin.Conclusions: These data demonstrate that UV-A can decrease bacterial proliferation and promote wound healing when coupled with NPWT. (J Am Podiatr Med Assoc 113(1), 2023)
C1 [Davis, Kathryn E.; Bills, Jessica; Noble, Debby; Crisologo, Peter A.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr, Dept Plast Surg, Dallas, TX USA.
   [Crisologo, Peter A.] Univ Cincinnati Med Ctr, Dept Surg, Cincinnati, OH USA.
   [Davis, Kathryn E.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd F4-310A, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University System of Ohio; University of Cincinnati; University
   of Texas System; University of Texas Southwestern Medical Center
RP Davis, KE (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd F4-310A, Dallas, TX 75390 USA.
EM kathryn.davis@utsouthwestern.edu
RI Crisologo, Peter/JZE-5379-2024
OI Crisologo, Peter/0000-0002-5367-9235
FU Thermotek, Inc.; Cardinal Health; Avazzia; EO2 Concepts; MedImmune;
   Pluristem Therapeutics Inc; Osiris Therapeutics; KCI; Pluristem
   Therapeutics, Inc
FX This study was supported by an educational grant from Thermotek, Inc.
   Kathryn E. Davis, PhD, has research funding from Cardinal Health,
   Avazzia, EO2 Concepts, MedImmune, Pluristem Therapeutics Inc, Osiris
   Therapeutics; and consulting agreements with EO2 Concepts, Cardinal
   Health, Bayer, Medline Industries, Boehringer Ingelheim, and Medimmune.
   Jessica Bills, BS, and Debby Noble, BS, have no relevant conflicts of
   interest. Lawrence A. Lavery, DPM, MPH, has research funding from
   Cardinal Health, KCI, EO2 Concepts, Osiris Therapeutics, Avazzia, and
   Pluristem Therapeutics, Inc; and consulting agreements with EO2
   Concepts, Cardinal Health, Bayer, Medline Industries, Boehringer
   Ingelheim, and Medimmune.
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NR 36
TC 0
Z9 0
U1 0
U2 8
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD JAN-FEB
PY 2023
VL 113
IS 1
AR 251
DI 10.7547/20-251
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA Z4TW1
UT WOS:001112027400005
PM 34233359
DA 2026-07-24
ER
PT J
AU Robu, M
   Radulescu, B
   Margarint, I
   Stiru, O
   Antoniac, I
   Gheorghita, D
   Voica, C
   Nica, C
   Cacoveanu, M
   Iliuta, L
   Iliescu, VA
   Moldovan, H
AF Robu, Mircea
   Radulescu, Bogdan
   Margarint, Irina
   Stiru, Ovidiu
   Antoniac, Iulian
   Gheorghita, Daniela
   Voica, Cristian
   Nica, Claudia
   Cacoveanu, Mihai
   Iliuta, Luminita
   Iliescu, Vlad Anton
   Moldovan, Horatiu
TI Surgical Strategy for Sternal Closure in Patients with Surgical
   Myocardial Revascularization Using Mammary Arteries
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Article
DE coronary artery bypass grafting (CABG); sternal closure; sternal
   osteosynthesis
ID INTERNAL-THORACIC-ARTERY; WOUND-INFECTION; SURGERY; SURVIVAL; OUTCOMES;
   GRAFTS
AB Background: Coronary artery bypass grafting has evolved from all venous grafts to bilateral mammary artery (BIMA) grafting. This was possible due to the long-term patency of the left and right internal mammary demonstrated in angiography studies compared to venous grafts. However, despite higher survival rates when using bilateral mammary arteries, multiple studies report a higher rate of surgical site infections, most notably deep sternal wound infections, a so-called "never event". Methods: We designed a prospective study between 1 January 2022 and 31 December 2022 and included all patients proposed for total arterial myocardial revascularization in order to investigate the rate of surgical site infections (SSI). Chest closure in all patients was performed using a three-step protocol. The first step refers to sternal closure. If the patient's BMI is below 35 kg/m2, sternal closure is achieved using the "butterfly" technique with standard steel wires. If the patient's BMI exceeds 35 kg/m2, we use nitinol clips or hybrid wire cable ties according to the surgeon's preference for sternal closure. The main advantages of these systems are a larger implant-to-bone contact with a reduced risk of bone fracture. The second step refers to presternal fat closure with two resorbable monofilament sutures in a way that the edges of the skin perfectly align at the end. The third step is skin closure combined with negative pressure wound therapy. Results: This system was applied to 217 patients. A total of 197 patients had bilateral mammary artery grafts. We report only 13 (5.9%) superficial SSI and only one (0.46%) deep SSI. The preoperative risk of major wound infection was 3.9 +/- 2.7. Bilateral mammary artery grafting was not associated with surgical site infection in a univariate analysis. Conclusions: We believe this strategy of sternal wound closure can reduce the incidence of deep surgical site infection when two mammary arteries are used in coronary artery bypass surgery.
C1 [Robu, Mircea; Radulescu, Bogdan; Margarint, Irina; Stiru, Ovidiu; Iliescu, Vlad Anton; Moldovan, Horatiu] Carol Davila Univ Med & Pharm, Fac Med, Bucharest 050474, Romania.
   [Robu, Mircea; Radulescu, Bogdan; Stiru, Ovidiu; Iliuta, Luminita; Iliescu, Vlad Anton] CC Iliescu Emergency Inst Cardiovasc Dis, Dept Cardiovasc Surg, Bucharest 022322, Romania.
   [Antoniac, Iulian; Gheorghita, Daniela] Natl Univ Sci & Technol, Fac Mat Sci & Engn, Politehn Bucharest, Bucharest 060042, Romania.
   [Antoniac, Iulian; Moldovan, Horatiu] Acad Romanian Scientists, 54 Spl Independentei, Bucharest 050711, Romania.
   [Voica, Cristian; Nica, Claudia; Cacoveanu, Mihai; Moldovan, Horatiu] Clin Emergency Hosp Bucharest, Dept Cardiovasc Surg, Bucharest 014461, Romania.
C3 Carol Davila University of Medicine & Pharmacy; National University of
   Science & Technology POLITEHNICA Bucharest; Academy of Romanian
   Scientists (AOSR)
RP Robu, M; Radulescu, B (通讯作者)，Carol Davila Univ Med & Pharm, Fac Med, Bucharest 050474, Romania.; Robu, M; Radulescu, B (通讯作者)，CC Iliescu Emergency Inst Cardiovasc Dis, Dept Cardiovasc Surg, Bucharest 022322, Romania.
EM mircea.robu@drd.umfcd.ro; bogdan.radulescu@drd.umfcd.ro;
   irina-maria.margarint@drd.umfcd.ro; ovidiu.stiru@umfcd.ro;
   antoniac.iulian@gmail.com; daniela.mgm8@gmail.com;
   cristianvoica@yahoo.com; bianca.nica@yahoo.com;
   catalin.cacoveanu@gmail.com; luminitailiuta@yahoo.com;
   vladanton.iliescu@gmail.com; h_moldovan@hotmail.com
RI Moldovan, Horatiu/G-8773-2016; Iliuta, Luminita/ITT-1357-2023; robu,
   mircea/IVU-7624-2023; Gheorghita, Daniela/AAH-1893-2020; Iulian,
   Antoniac/D-4802-2014; Stiru, Ovidiu/AAA-5398-2019; Iliescu, Vlad
   Anton/AAA-7692-2019; Voica, Cristian/HTR-7048-2023
OI Moldovan, Horatiu/0000-0002-2241-279X; Iliuta,
   Luminita/0000-0002-1439-5002; robu, mircea/0000-0003-3599-129X;
   Gheorghita, Daniela/0000-0003-3660-8926; Iulian,
   Antoniac/0000-0003-0112-3494; Stiru, Ovidiu/0000-0002-5482-6794;
   Iliescu, Vlad Anton/0000-0001-9069-2722; 
FU University of Medicine and Pharmacy Carol Davila
FX The publication of this paper was supported by the University of
   Medicine and Pharmacy Carol Davila, through the institutional program
   Publish not Perish.
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NR 29
TC 3
Z9 3
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD NOV
PY 2023
VL 10
IS 11
AR 457
DI 10.3390/jcdd10110457
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Z7FN4
UT WOS:001113695400001
PM 37998515
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Babu, B
   Gaba, S
   John, JR
   Subair, M
AF Babu, Basil
   Gaba, Sunil
   John, Jerry R.
   Subair, Mohsina
TI Comparison of Efficacy of Vacuum Dressing Versus Conventional Dressing
   Over Autologous Split Skin Grafts in Burn Wounds: A Single-Center
   Prospective Cohort Study
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
DE burns; vacuum dressing; negative-pressure wound therapy; skin grafts
ID PRESSURE; THERAPY; TRIAL
AB This study was carried out to compare the efficacy of vacuum dressing and conventional dressing over split skin grafts in burn patients. It was a single-center prospective cohort study on patients, with less than 40% TBSA burn, undergoing skin grafting at 2 different sites simultaneously over the burn wounds. One site underwent conventional dressing following grafting, and the other underwent vacuum dressing. The primary objective was to compare the percentages of skin graft uptake on Day 5 and Day 14. The secondary objectives were to compare the duration of dressings, time for complete epithelization, need for regrafting, and wound swab culture positivity rates. Three independent examiners assessed the efficacy of dressings in terms of epithelization percentage, need for continued dressing, graft loss, wound swab culture positivity rate, and qualitative assessment of grafts. A total of 16 patients were included in the study. The graft loss, number of days of dressings, and complete epithelization time were statistically lower in the negative-pressure wound therapy (NPWT) group compared with the conventional group (P values .007, .006, and 0009, respectively). The percentage of epithelization was also found to be higher in the NPWT group (P = .006). The incidence of positive cultures and clinically significant graft loss was found to be lower in the NPWT group. However, this was not found to be statistically significant. NPWT dressings can be used in burn wounds following skin grafting and have been found to reduce the time for epithelization compared to conventional dressing.
C1 [Babu, Basil] Post Grad Inst Med Educ & Res PGIMER, Dept Gen Surg, Chandigarh 160012, India.
   [Gaba, Sunil; John, Jerry R.; Subair, Mohsina] Post Grad Inst Med Educ & Res PGIMER, Dept Plast & Reconstruct Surg, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh
RP Babu, B (通讯作者)，Post Grad Inst Med Educ & Res PGIMER, Dept Gen Surg, Chandigarh 160012, India.
EM drbasilms@gmail.com
RI ; subair, mohsina/JWO-9377-2024; Babu, Basil/KFR-4984-2024
OI Gaba, Sunil/0000-0001-8743-5987; subair, mohsina/0000-0003-0164-0053;
   Babu, Basil/0009-0007-0087-5105
CR Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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NR 14
TC 3
Z9 3
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR 4
PY 2024
VL 45
IS 2
BP 468
EP 477
DI 10.1093/jbcr/irad181
EA NOV 2023
PG 10
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA KD8C6
UT WOS:001114023100001
PM 37950743
DA 2026-07-24
ER
PT J
AU Sun, HX
   Fu, J
   Wen, B
   Zhang, LL
   Zhao, Y
   Li, X
   Li, ZJ
   Tang, LH
   Xin, JB
AF Sun, Haoxuan
   Fu, Jun
   Wen, Bo
   Zhang, Lili
   Zhao, Yi
   Li, Xiang
   Li, Zhijun
   Tang, Lihua
   Xin, Jiangbo
TI Original Negative pressure sealing drainage technology combined with
   adequate irrigation for oral and maxillofacial space infection can
   improve serum inflammatory factor levels
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Vacuum sealing drainage; full irrigation treatment; oral and
   maxillofacial space infection; clinical efficacy; inflammatory factors
ID COMPLICATIONS; MANAGEMENT; WOUNDS
AB Objective: This study aimed to assess the clinical efficacy of combining vacuum sealing drainage with full irrigation in managing oral and maxillofacial space infections and its impact on serum inflammatory factor levels in patients. Methods: We retrospectively analyzed data from 110 patients with oral and maxillofacial space infections treated at our hospital between February 2018 and March 2022. Among them, 50 patients underwent simple negative pressure closed drainage (control group), while 60 patients received combined full irrigation using 0.9% sodium chloride solution (observation group). We compared clinical treatment outcomes, treatment duration, antibiotic usage duration, quality of life scores, Visual Analogue Scale (VAS) scores, changes in serum IL-6 and TNF-alpha levels be-fore and after treatment, and the incidence of complications between the two groups. Additionally, we conducted an analysis of risk factors influencing patient prognosis. Results: The observation group exhibited significantly superior treatment efficacy compared to the control group (P < 0.05). Treatment and antibiotic usage durations were shorter in the observation group (P < 0.05). VAS scores after treatment were significantly lower in the observation group (P < 0.05). Serum inflammatory factors improved significantly in both groups after treatment, with a more substantial improvement observed in the observation group (P < 0.05). Post-treatment quality of life was significantly higher, and the incidence of complications was lower in the observation group (P < 0.05). The choice of treatment method independently influenced patient prognosis (P < 0.05). Conclusion: Combining vacuum sealing drainage with full irrigation is an effective approach for managing oral and maxillofacial space infections. This treatment leads to improved clinical symptoms, reduced inflammatory responses, decreased pain intensity, and enhanced quality of life while maintaining safety.
C1 [Sun, Haoxuan; Zhang, Lili; Li, Xiang; Li, Zhijun; Xin, Jiangbo] Hebei Eye Hosp, Oral & Maxillofacial Surg Ward, 399 Quanbei East St,Xiangdu Dist, Xingtai 054001, Hebei, Peoples R China.
   [Fu, Jun] Hebei Eye Hosp, Med Imaging Dept, 399 Quanbei East St,Xiangdu Dist, Xingtai 054001, Hebei, Peoples R China.
   [Wen, Bo] Hebei Eye Hosp, Med Records & Stat Room,399 Quanbei East St,Xiangd, Xingtai 054001, Hebei, Peoples R China.
   [Zhao, Yi; Tang, Lihua] Hebei Eye Hosp, Hosp Operating Room, 399 Quanbei East St,Xiangdu Dist, Xingtai 054001, Hebei, Peoples R China.
   [Zhao, Yi; Tang, Lihua] Hebei Eye Hosp, Anesthesia Dept, 399 Quanbei East St,Xiangdu Dist, Xingtai 054001, Hebei, Peoples R China.
RP Xin, JB (通讯作者)，Hebei Eye Hosp, Oral & Maxillofacial Surg Ward, 399 Quanbei East St,Xiangdu Dist, Xingtai 054001, Hebei, Peoples R China.
EM xjb66880811@163.com
RI Li, Zhijun/LLK-0729-2024
CR Breckenridge JD, 2011, J PHYSIOTHER, V57, P197, DOI 10.1016/S1836-9553(11)70045-5
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NR 22
TC 8
Z9 8
U1 0
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2023
VL 15
IS 11
BP 6605
EP 6612
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA Z8DG8
UT WOS:001114320500016
PM 38074802
DA 2026-07-24
ER
PT J
AU Kleeven, A
   Van der Hel, SRP
   Jonis, YMJ
   Profar, JJA
   Daemen, JHT
   de Loos, ER
   Van der Hulst, RRWJ
   Qiu, SS
AF Kleeven, Alieske
   Van der Hel, Seth Rianna P.
   Jonis, Yasmine M. J.
   Profar, Jairo J. A.
   Daemen, Jean H. T.
   de Loos, Erik R.
   Van der Hulst, Rene R. W. J.
   Qiu, Shan Shan
TI Chest wall reconstruction after the Clagett procedure and other types of
   open-window thoracostomy: a narrative review
SO JOURNAL OF THORACIC DISEASE
LA English
DT Review
DE Empyema; Clagett; open-window thoracostomy; reconstruction
ID PARASPINOUS MUSCLE FLAP; BRONCHOPLEURAL FISTULA; SUCCESSFUL CLOSURE;
   CHRONIC EMPYEMA; MANAGEMENT; CAVITY; SPACE
AB Background and Objective: The Clagett procedure is one of the last treatment options for chronic stage pleural empyema. It involves the formation of an open-window in the thoracic wall to allow for continuous drainage and irrigation of the pleural cavity. Once the empyema has been resolved, reconstruction of the chest wall is sometimes challenging. This review aims to identify and summarize the options for reconstructing soft tissue defects of the chest wall following the Clagett procedure and other types of open window thoracostomy.
   Methods: A narrative review was performed of the literature on PubMed, Cochrane Library, ClinicalTrials.gov, and Google Scholar, including all relevant studies published until January 2023.
   Key Content and Findings: This review contains an overview of the reconstruction methods and the outcomes of the included studies on reconstructive options after the Clagett procedure and other types of open-window thoracostomy. A subdivision was made based on reconstruction type: pedicled flaps, free flaps, and the use of a vacuum-assisted closure (VAC) device. The advantages of pedicled flaps are reliable vascularization, better tissue match, reduced scarring, and shorter operation time compared to free flaps. However, when pedicled flaps are not available due to damage during previous surgeries or offer insufficient volume to obliterate the cavity, free flaps might be a solution.
   Conclusions: In cases where an open-window thoracostomy necessitates chest wall reconstruction, a pedicled flap is the preferred choice, followed by free flaps. Additionally, vacuum-assisted negative pressure wound therapy (VANPWT) techniques have shown potentially promising results (as an adjunct to surgical treatment).
C1 [Kleeven, Alieske; Van der Hel, Seth Rianna P.; Jonis, Yasmine M. J.; Profar, Jairo J. A.; Van der Hulst, Rene R. W. J.; Qiu, Shan Shan] Maastricht Univ, Med Ctr, Dept Plast Reconstruct & Hand Surg, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
   [Daemen, Jean H. T.; de Loos, Erik R.] Zuyderland Med Ctr, Div Gen Thorac Surg, Dept Surg, Heerlen, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Zuyderland Medical Center
RP Qiu, SS (通讯作者)，Maastricht Univ, Med Ctr, Dept Plast Reconstruct & Hand Surg, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
EM shanshan.qiushao@mumc.nl
OI qiu, shan shan/0000-0002-0616-9566
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NR 44
TC 6
Z9 7
U1 0
U2 1
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2072-1439
EI 2077-6624
J9 J THORAC DIS
JI J. Thorac. Dis.
PD DEC
PY 2023
VL 15
IS 12
BP 7063
EP 7076
DI 10.21037/jtd-23-684
EA DEC 2023
PG 14
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA ED4F6
UT WOS:001117020100001
PM 38249872
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lee, DY
   Eo, S
   Lim, S
   Yoon, JS
AF Lee, Dong Yun
   Eo, SuRak
   Lim, SooA
   Yoon, Jung Soo
TI Successful pedicled vertical rectus abdominis myocutaneous flap
   reconstruction with negative-pressure wound therapy for deep sternal
   wound infection: a case report and comprehensive review
SO FRONTIERS IN SURGERY
LA English
DT Review
DE vertical rectus abdominis myocutaneous (VRAM) flap; deep sternal wound
   infection (DSWI); negative-pressure wound therapy (NPWT); cardiac
   injury; case report
ID CARDIAC-SURGERY; PREVENTION; STERNOTOMY
AB IntroductionDeep sternal wound infection (DSWI) is a serious complication that may occur after median sternotomy, with potentially devastating consequences. By reporting our case and analyzing the existing literature, this article aimed to provide a thorough understanding of the role of negative-pressure wound therapy (NPWT) and the importance of flap choice in managing DSWI accompanied by severe heart injury and high hemodynamic risk.Case descriptionA 60-year-old woman with severe aortic stenosis, aortic valve regurgitation, and heart failure underwent redo sternotomy, which resulted in an intraoperative right ventricle injury. She required extracorporeal membrane oxygenation support because of low blood pressure and subsequently developed complications, including surgical site hematoma, wound dehiscence, and fat necrosis. She was referred for wound closure, where a significant 10 x 20-cm soft tissue defect in the anterior chest wall was observed. A pedicled vertical rectus abdominis myocutaneous flap addressed the soft tissue defect. The wound showed remarkable improvement at the 8-month follow-up visit.ConclusionsDSWI management is a complex and multifaceted challenge. NPWT, when combined with appropriate surgical strategies, including wound debridement and flap selection, may promote successful wound healing. This case report highlights the successful management of a complex DSWI using a multidisciplinary approach, including debridement, appropriate antibiotic therapy, and free-flap reconstruction, which resulted in favorable outcomes.
C1 [Lee, Dong Yun; Eo, SuRak; Lim, SooA; Yoon, Jung Soo] DongGuk Univ, Med Ctr, Dept Plast & Reconstruct Surg, Seoul, South Korea.
C3 Dongguk University
RP Yoon, JS (通讯作者)，DongGuk Univ, Med Ctr, Dept Plast & Reconstruct Surg, Seoul, South Korea.
EM crsboys@naver.com
RI ; Eo, SuRak/JXM-4124-2024; Lee, Dong Yun/QPA-1583-2026
OI Yoon, Jung Soo/0000-0003-2462-5702; Lee, Dong Yun/0000-0002-5323-6469
FU The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
FX No Statement Available
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NR 12
TC 1
Z9 3
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD NOV 6
PY 2023
VL 10
AR 1268555
DI 10.3389/fsurg.2023.1268555
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AP1I2
UT WOS:001119571000001
PM 38026493
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Xu, Y
   Shao, S
   Gong, ZZ
   Ri, H
   Xu, ZH
   Kang, HN
   Shan, Y
   Amadou, BH
   Ren, YY
   Zhang, F
   Chen, X
AF Xu, Yang
   Shao, Shuai
   Gong, ZeZhong
   Ri, HyokJu
   Xu, ZhaoHui
   Kang, HaoNan
   Shan, Yan
   Amadou, Boureima Hamidou
   Ren, YanYing
   Zhang, Fan
   Chen, Xin
TI Efficacy of prophylactic negative pressure wound therapy after open
   ventral hernia repair: a systematic review meta-analysis
SO BMC SURGERY
LA English
DT Review
DE Ventral hernia; Surgical site occurrences; OVHR; NPWT
ID MANAGEMENT; OUTCOMES; INFECTION; DRESSINGS; REDUCTION; COST
AB Introduction The susceptibility to surgical site occurrence (SSO) is high following ventral hernia repair (VHR) surgery. SSO severely increases the physical and mental burden on patients. The main purpose of this review was to analyze the efficacy of negative pressure wound therapy (NPWT) after open VHR(OVHR) and explore benefits to patients.Methods The Cochrane Library, PubMed, and Embase databases were searched from the date of establishment to 15 October 2022. All randomized controlled trials and retrospective cohort studies comparing NPWT with standard dressings after OVHR were included. The Revman 5.4 software recommended by Cochrane and the STATA16 software were used in this meta-analysis.Results Fifteen studies (involving 1666 patients) were identified and included in the meta-analysis, with 821 patients receiving NPWT. Overall, the incidence rate of SSO in the NPWT group was lower compared to the control group (odds ratio [OR] = 0.44; 95% confidence interval [CI] = 0.21-0.93; I-2 = 86%; P = 0.03). The occurrence rate of surgical site infection (SSI; OR = 0.51; 95% CI = 0.38-0.68, P < 0.001), wound dehiscence (OR = 0.64; 95% CI = 0. 43-0.96; P = 0.03), and hernia recurrence (OR = 0.51; 95% CI = 0.28-0.91, P = 0.02) was also lowered. There was no significant difference in seroma (OR = 0.76; 95% CI = 0.54-1.06; P = 0.11), hematoma (OR = 0.53; 95% CI = 0.25-1.11; P = 0.09), or skin necrosis (OR = 0.83; 95% CI = 0.47-1.46; P = 0.52).Conclusion NPWT can effectively decrease the occurrence of SSO, SSI wound dehiscence and hernia recurrence and should be considered following OVHR.
C1 [Xu, Yang; Shao, Shuai; Gong, ZeZhong; Ri, HyokJu; Xu, ZhaoHui; Kang, HaoNan; Shan, Yan; Amadou, Boureima Hamidou; Ren, YanYing; Zhang, Fan; Chen, Xin] Dalian Med Univ, Dept Hernia & Colorectal Surg, Hosp 2, Dalian 116023, Peoples R China.
   [Ri, HyokJu] Hosp Pyongyang Med Coll, Dept Colorectal Surg, Pyongyang 999093, North Korea.
C3 Dalian Medical University
RP Chen, X (通讯作者)，Dalian Med Univ, Dept Hernia & Colorectal Surg, Hosp 2, Dalian 116023, Peoples R China.
EM chenxincjz@gmail.com
RI ; shao, shuai/KVA-8071-2024
OI Ri, HyokJu/0000-0002-5172-7029; 徐, 阳/0000-0002-6923-8274; 
FU Second Hospital of Dalian Medical University [2022JCXKYB01,
   2022JCXKYB20]; Dalian Medical Science Research Project [2012023]
FX <STRONG> </STRONG>This work was supported by the "1 + X" program for the
   Clinical Competency Enhancement -Interdisciplinary Innovation
   Project,The Second Hospital of Dalian Medical University (2022JCXKYB01,
   2022JCXKYB20), and the Dalian Medical Science Research Project
   (2012023).
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NR 47
TC 6
Z9 9
U1 1
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD DEC 11
PY 2023
VL 23
IS 1
AR 374
DI 10.1186/s12893-023-02280-4
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CF0G4
UT WOS:001123712500001
PM 38082353
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Takahashi, H
   Takeda, S
   Tanaka, Y
   Shibata, R
   Ito, H
   Kurahashi, S
   Mitsuya, S
   Murakami, H
AF Takahashi, Hiroshi
   Takeda, Shinsuke
   Tanaka, Yoshihiro
   Shibata, Ryutaro
   Ito, Hiroki
   Kurahashi, Shingo
   Mitsuya, So
   Murakami, Hideki
TI Effectiveness of Specific Single-Use Incisional Negative Pressure Wound
   Therapy (PICO System) After Major Lower Extremity Amputation
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE lower extremity amputation; diabetes; wound management; arterial
   occlusive disease
AB Lower extremity amputation (LEA), particularly in patients with diabetes or peripheral vascular disease, often results in complications such as surgical site infections (SSIs) and wound dehiscence. This study examined whether utilizing the portable and user-friendly PICO system (Smith and Nephew Medical Ltd, Hull, UK) as incisional negative-pressure wound therapy can reduce post-LEA complications. This study was conducted at a Japanese tertiary medical center and involved a retrospective analysis of LEA cases (n = 32) between January 2021 and December 2022. The PICO dressing group (n = 16) was compared to the conventional dressing group (n = 16) for post-LEA wound management. The primary outcome was the incidence of postoperative wound complications, including SSI and wound dehiscence, within 15 days of LEA. Superficial/deep SSI and wound dehiscence occurred less frequently in the PICO dressing group than in the conventional dressing group (12.5% vs 43.8%; p = .054). There were no cases of deep SSIs in the PICO dressing group. Although this study has limitations owing to its retrospective design and small sample size, the results suggest the potential of the PICO system for improving outcomes in post-LEA wound management.
C1 [Takahashi, Hiroshi; Takeda, Shinsuke; Shibata, Ryutaro; Murakami, Hideki] Nagoya City Univ Hosp, Dept Orthopaed Surg, Nagoya, Japan.
   [Takahashi, Hiroshi] Khon Kaen Univ, Fac Med, Dept Orthoped, Khon Kaen, Thailand.
   [Tanaka, Yoshihiro] Shizuoka Grad Univ Publ Hlth, Sch Publ Hlth, Div Epidemiol, Shizuoka, Japan.
   [Shibata, Ryutaro; Ito, Hiroki; Kurahashi, Shingo; Mitsuya, So] Toyohashi Municipal Hosp, Trauma & Microsurg Ctr, Toyohashi, Japan.
   [Takeda, Shinsuke] Nagoya City Univ, Grad Sch Med Sci, Dept Orthopaed Surg, 1 Kawasumi, Nagoya, Aichi 4678602, Japan.
C3 Nagoya City University; Khon Kaen University; Nagoya City University
RP Takeda, S (通讯作者)，Nagoya City Univ, Grad Sch Med Sci, Dept Orthopaed Surg, 1 Kawasumi, Nagoya, Aichi 4678602, Japan.
EM s7.takeda.jpn@gmail.com
RI Tanaka, Yoshihiro/ABH-3503-2021
OI Tanaka, Yoshihiro/0000-0002-6150-1592; Takeda,
   Shinsuke/0000-0002-9801-3963
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NR 14
TC 3
Z9 3
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2025
VL 24
IS 1
SI SI
BP 130
EP 134
DI 10.1177/15347346231221116
EA DEC 2023
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA Y0X7J
UT WOS:001124410800001
PM 38092691
OA Bronze
DA 2026-07-24
ER
PT J
AU Stemkens, R
   Cobussen, M
   de Laat, E
   Hoefsloot, W
   van Crevel, R
   Aarnoutse, RE
   van Ingen, J
AF Stemkens, Ralf
   Cobussen, Maarten
   de laat, Erik
   Hoefsloot, Wouter
   van Crevel, Reinout
   Aarnoutse, Rob E.
   van Ingen, Jakko
TI Successful addition of topical antibiotic treatment after surgery in
   treatment-refractory nontuberculous mycobacterial skin and
   softtissueinfectionssoft tissue infections
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
DE nontuberculous mycobacteria; skin and soft tissue infections; topical
   antibiotic treatment
AB Treatment of skin and soft tissue infections with nontuberculous mycobacteria sometimes fails despite repeated debridements and long-term systemic antibiotic therapy. These treatment-refractory infections can cause significant morbidity and pose a treatment challenge. Following surgery, we treated three patients with negative pressure wound therapy with the instillation and dwell time of topical antibiotics, in addition to systemic antibiotic treatment. Treatment was successful and well tolerated, except for some local irritation.
C1 [Stemkens, Ralf; Aarnoutse, Rob E.] Radboud Univ Nijmegen, Res Inst Med Innovat, Dept Pharm, Med Ctr, Nijmegen, Netherlands.
   [Cobussen, Maarten; van Crevel, Reinout] Radboud Univ Nijmegen, Res Inst Med Innovat, Dept Internal Med & Infect Dis, Med Ctr, Nijmegen, Netherlands.
   [de laat, Erik] Radboud Univ Nijmegen, Res Inst Med Innovat, Dept Plast Surg, Med Ctr, Nijmegen, Netherlands.
   [Hoefsloot, Wouter] Radboud Univ Nijmegen, Res Inst Med Innovat, Dept Pulm Dis, Radboud Univ, Nijmegen, Netherlands.
   [van Ingen, Jakko] Radboud Univ Nijmegen, Dept Med Microbiol, Med Ctr, Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Radboud
   University Nijmegen; Radboud University Nijmegen; Radboud University
   Nijmegen
RP Stemkens, R (通讯作者)，Radboud Univ Nijmegen, Res Inst Med Innovat, Dept Pharm, Med Ctr, Nijmegen, Netherlands.
EM ralf.stemkens@radboudumc.nl
RI van Crevel, reinout/A-6636-2010; Hoefsloot, W./L-4376-2015; Aarnoutse,
   R.E./L-4168-2015; van Ingen, Jakko/D-5526-2014; /P-8241-2015; Stemkens,
   Ralf/AAQ-3932-2020; , reinout/A-6636-2010
OI van Ingen, Jakko/0000-0002-0581-2003; Stemkens,
   Ralf/0009-0008-6912-4163; , reinout/0000-0002-6233-6410
CR Bricheux A, 2019, CLIN MICROBIOL INFEC, V25, DOI 10.1016/j.cmi.2018.11.020
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NR 11
TC 9
Z9 10
U1 0
U2 7
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD DEC
PY 2023
VL 67
IS 12
DI 10.1128/aac.00788-23
EA NOV 2023
PG 6
WC Microbiology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Pharmacology & Pharmacy
GA 6DF8D
UT WOS:001124422800002
PM 38014946
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Nguyen, DC
   Buettner, AM
   Dousa, KM
AF Nguyen, David C.
   Buettner, Angel M.
   Dousa, Khalid M.
TI Case Commentary: Another prong of attack? Topical antibiotic
   instillation with negative pressure wound therapy for nontuberculous
   mycobacterial skin and soft tissue infections
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
DE Mycobacterium; skin and soft tissue Infection; negative pressure wound
   therapy; wound
AB Nontuberculous mycobacteria (NTM) skin infections remain therapeutically challenging. Given the diversity in infections, host responses, and antimicrobials, clinical guidelines are often built on case series and observational studies. In this commentary, we respond to a paper by Stemkens et al. that introduces an emerging strategy: adjunctive negative pressure wound therapy with instillation and dwell time combined with topical antibiotics for refractory NTM skin and soft tissue infections. We delve into the primary considerations surrounding this innovative approach.
C1 [Nguyen, David C.] Rush Med Coll, Div Pediat Infect Dis, Dept Pediat, Chicago, IL USA.
   [Nguyen, David C.] Rush Med Coll, Div Infect Dis, Dept Internal Med, Chicago, IL USA.
   [Buettner, Angel M.] Advocate Aurora Healthcare Syst, Dept Hyperbar Med & Wound Care, Sheboygan, WI USA.
   [Dousa, Khalid M.] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA.
   [Dousa, Khalid M.] Vet Affairs Northeast Ohio Healthcare Syst, Cleveland, OH 44106 USA.
C3 Rush University; Rush University; University System of Ohio; Case
   Western Reserve University
RP Dousa, KM (通讯作者)，Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA.; Dousa, KM (通讯作者)，Vet Affairs Northeast Ohio Healthcare Syst, Cleveland, OH 44106 USA.
EM kxd231@case.edu
OI Nguyen, David/0000-0001-5738-2976; Dousa, Khalid M/0000-0003-3272-7231
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   van Wijk F, 2020, ANTIMICROB AGENTS CH, V64, DOI 10.1128/AAC.01203-19
NR 14
TC 1
Z9 2
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD DEC
PY 2023
VL 67
IS 12
DI 10.1128/aac.01048-23
EA NOV 2023
PG 3
WC Microbiology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Pharmacology & Pharmacy
GA 6DF8D
UT WOS:001124422800003
PM 38014943
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Traylor, LB
   Bhatia, G
   Blackhurst, D
   Wallenborn, G
   Ewing, A
   Bolton, W
   Davis, B
AF Traylor, L. B.
   Bhatia, G.
   Blackhurst, D.
   Wallenborn, G.
   Ewing, A.
   Bolton, W.
   Davis, B.
TI Efficacy of incisional negative pressure therapy in preventing
   post-sternotomy wound complications
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID RISK-FACTORS; INFECTION; MANAGEMENT; SITE; MORTALITY; CLOSURE
AB Background: Sternal wound infections represent a source of significant morbidity and mortality following median sternotomy. The use of incisional negative pressure wound therapy in prevention has yet to be elucidated.
   Methods: A retrospective study was conducted before and after a universal wound care protocol was implemented including the prophylactic use of negative pressure wound therapy (NPWT). The primary endpoint was sternal infections within 90 days of the index operation.
   Results: In the control period, there was a 3.0% rate of sternal infection within 90 days compared to 0.8% in the intervention period (p < 0.001). An odds ratio of 0.25 (95% confidence interval 0.11, 0.57; p < 0.001) in the intervention period as compared to the control period was demonstrated.
   Conclusions: The use of a standardized wound care protocol including the universal application of NPWT for patients undergoing cardiac surgery with median sternotomy was an independent predictor of decreased rates of sternal infection.
   (c) 2023 Elsevier Inc. All rights reserved.
C1 [Traylor, L. B.] Univ South Carolina, Sch Med Greenville, Greenville, SC 29605 USA.
   [Bhatia, G.; Blackhurst, D.; Wallenborn, G.; Ewing, A.; Bolton, W.; Davis, B.] Prisma Hlth Upstate, Greenville, SC 29605 USA.
C3 Prisma Health
RP Bhatia, G (通讯作者)，Prisma Hlth Upstate, Greenville, SC 29605 USA.
EM gautam.bhatia@prismahealth.org
OI Bhatia, Gautam/0009-0007-1029-3395; Traylor, Lawson/0000-0001-5684-2176
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   Lemaignen A, 2015, Clin Microbiol Infect, V21, DOI [10.1016/j.cmi.2015.03.025, 10.1016/j.cmi.2015.03.025]
   Levy AS, 2021, PLAST RECONSTR SURG, V148, P429, DOI 10.1097/PRS.0000000000008168
   Madjarov JM, 2021, J CARDIAC SURG, V36, P3155, DOI 10.1111/jocs.15687
   Magro PL, 2021, INTERACT CARDIOV TH, V32, P452, DOI 10.1093/icvts/ivaa292
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   Morisaki A, 2011, GEN THORAC CARDIOVAS, V59, P261, DOI 10.1007/s11748-010-0727-3
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   SAS Institute, 2022, SAS Enterprise Guide, V3
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   Suelo-Calanao RL, 2020, J CARDIOTHORAC SURG, V15, DOI 10.1186/s13019-020-01265-1
   Tabley A, 2020, ANN THORAC SURG, V110, P2034, DOI 10.1016/j.athoracsur.2020.03.087
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NR 34
TC 4
Z9 4
U1 0
U2 0
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD DEC
PY 2023
VL 226
IS 6
BP 762
EP 767
DI 10.1016/j.amjsurg.2023.07.016
EA NOV 2023
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CI4A2
UT WOS:001124598300001
PM 37453803
DA 2026-07-24
ER
PT J
AU Yamamoto, R
   Kuramoto, S
   Shimizu, M
   Shinozaki, H
   Miyake, T
   Sadakari, Y
   Sekine, K
   Kaneko, Y
   Kurosaki, R
   Koizumi, K
   Shibusawa, T
   Sakurai, Y
   Wakahara, S
   Sasaki, J
AF Yamamoto, Ryo
   Kuramoto, Shunsuke
   Shimizu, Masayuki
   Shinozaki, Hiroharu
   Miyake, Tasuku
   Sadakari, Yoshihiko
   Sekine, Kazuhiko
   Kaneko, Yasushi
   Kurosaki, Ryo
   Koizumi, Kiyoshi
   Shibusawa, Takayuki
   Sakurai, Yoshihiko
   Wakahara, Sota
   Sasaki, Junichi
CA OPTITAC study grp
TI Optimal tentative abdominal closure for open abdomen: a multicenter
   retrospective observational study (OPTITAC study)
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE abdominal sepsis; damage control surgery; fascia closure; high negative
   pressure; negative-pressure wound therapy
ID PRESSURE WOUND THERAPY; EARLY FASCIAL CLOSURE; EASTERN ASSOCIATION;
   PROGNOSTIC-FACTORS; MANAGEMENT; TRAUMA; SURGERY; EVOLUTION; WALL
AB Background: Primary fascia closure is often difficult following an open abdomen (OA). While negative-pressure wound therapy (NPWT) is recommended to enhance successful primary fascia closure, the optimal methods and degree of negative pressure remain unclear. This study aimed to elucidate optimal methods of NPWT as a tentative abdominal closure for OA to achieve primary abdominal fascia closure.Materials and Methods: A multicenter, retrospective, cohort study of adults who survived OA greater than 48 h was conducted in 12 institutions between 2010 and 2022. The achievement of primary fascia closure and incidence of enteroatmospheric fistula were examined based on methods (homemade, superficial NPWT kit, or open-abdomen kit) or degrees of negative pressure (<50, 50-100, or >100 mmHg). A generalized estimating equation was used to adjust for age, BMI, comorbidities, etiology for laparotomy requiring OA, vital signs, transfusion, severity of critical illness, and institutional characteristics.Results: Of the 279 included patients, 252 achieved primary fascia closure. A higher degree of negative pressure (>100 mmHg) was associated with fewer primary fascia closures than less than 50 mmHg [OR, 0.18 (95% CI: 0.50-0.69), P=0.012] and with more frequent enteroatmospheric fistula [OR, 13.83 (95% CI: 2.30-82.93)]. The methods of NPWT were not associated with successful primary fascia closure. However, the use of the open-abdomen kit was related to a lower incidence of enteroatmospheric fistula [OR, 0.02 (95% CI: 0.00-0.50)].Conclusion: High negative pressure (>100 mmHg) should be avoided in NPWT during tentative abdominal closure for OA.
C1 [Yamamoto, Ryo] Keio Univ, Sch Med, Dept Emergency & Crit Care Med, Tokyo, Japan.
   [Sekine, Kazuhiko; Wakahara, Sota] Tokyo Saiseikai Cent Hosp, Dept Emergency & Crit Care Med, Tokyo, Japan.
   [Shibusawa, Takayuki] Tokyo Med Ctr, Dept Emergency & Crit Care Med, Natl Hosp Org, Tokyo, Japan.
   [Sasaki, Junichi] St Marys Hosp, Dept Surg, Fukuoka, Japan.
   [Sadakari, Yoshihiko] Kenwakai Otemachi Hosp, Dept Surg, Fukuoka, Japan.
   [Kuramoto, Shunsuke; Miyake, Tasuku] Shimane Univ, Fac Med, Dept Acute Care Surg, Izumo, Shimane, Japan.
   [Kurosaki, Ryo] Japanese Red Cross Maebashi Hosp, Dept Surg, Fukuoka, Gunma, Japan.
   [Koizumi, Kiyoshi] Ashikaga Red Cross Hosp, Dept Cardiovasc Surg, Ashikaga, Tochigi, Japan.
   [Shinozaki, Hiroharu] Saiseikai Utsunomiya Hosp, Dept Surg, Utsunomiya, Tochigi, Japan.
   [Sakurai, Yoshihiko] Shonantobe Gen Hosp, Dept Surg, Yokosuka, Kanagawa, Japan.
   [Shimizu, Masayuki] Saiseikai Yokohamashi Tobu Hosp, Dept Trauma & Emergency Surg, Yokohama, Kanagawa, Japan.
   [Kaneko, Yasushi] Hiratsuka City Hosp, Dept Emergency & Crit Care Med, Hiratsuka, Kanagawa, Japan.
   [Yamamoto, Ryo] Keio Univ, Dept Emergency & Crit Care Med, Trauma Serv, Sch Med, 35 Shinanomachi,Shinju ku, Tokyo 1608582, Japan.
C3 Keio University; Tokyo Saiseikai Central Hospital; Shimane University;
   Keio University
RP Yamamoto, R (通讯作者)，Keio Univ, Dept Emergency & Crit Care Med, Trauma Serv, Sch Med, 35 Shinanomachi,Shinju ku, Tokyo 1608582, Japan.
EM ryo.yamamoto@gmail.com; s-kura@med.shimane-u.ac.jp;
   masayukizc4@gmail.com; hiroharu_shinozaki@saimiya.com;
   tasukun.0130@kenwakai.gr.jp; Y.Sadakari@gmail.com; skkazoo@yahoo.co.jp;
   y-kaneko0523@hotmail.co.jp; kuro3@k7.dion.ne.jp;
   kkoizumimed1023@gmail.com; takayukishibusawa@gmail.com;
   syoshi88801@yahoo.co.jp; soutamugen@gmail.com;
   sasakij@1989.jukuin.keio.ac.jp
RI ; Sasaki, Junichi/E-6992-2016; Yamamoto, Ryo/J-8017-2019; /C-5622-2011
OI Miyake, Tasuku/0009-0007-6339-7200; Wakahara, Sota/0009-0007-4827-6398; 
FU Japanese Society for Abdominal Emergency Medicine [2020-P-05]
FX This study received a research grant from the Japanese Society for
   Abdominal Emergency Medicine (2020-P-05).
CR Asensio JA, 2004, ARCH SURG-CHICAGO, V139, P209, DOI 10.1001/archsurg.139.2.209
   Bible J, 2019, STAT MED, V38, P903, DOI 10.1002/sim.8014
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   Bruhin A, 2014, INT J SURG, V12, P1105, DOI 10.1016/j.ijsu.2014.08.396
   Ceresoli M, 2020, WORLD J SURG, V44, P53, DOI 10.1007/s00268-019-05209-2
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   Coccolini F, 2019, INJURY, V50, P160, DOI 10.1016/j.injury.2018.09.040
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
   Coccolini F, 2017, WORLD J EMERG SURG, V12, DOI 10.1186/s13017-017-0146-1
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   Gill NA, 2011, WOUNDS, V23, P84
   Giudicelli G, 2017, J GASTROINTEST SURG, V21, P1328, DOI 10.1007/s11605-017-3453-7
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   Mahoney EJ, 2022, J TRAUMA ACUTE CARE, V93, pE110, DOI 10.1097/TA.0000000000003683
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   Young SR, 2013, INT WOUND J, V10, P383, DOI 10.1111/j.1742-481X.2012.00994.x
NR 32
TC 2
Z9 4
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD DEC
PY 2023
VL 109
IS 12
BP 4049
EP 4056
DI 10.1097/JS9.0000000000000687
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CK3M9
UT WOS:001125107900047
PM 37678286
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Pavan, F
   Tan, JD
   Gamage, S
   Vu, J
   Cashin, P
   Low, L
   Martin, S
AF Pavan, Fiona
   Tan, Jed
   Gamage, Sankalpa
   Vu, Joseph
   Cashin, Paul
   Low, Liang
   Martin, Sarah
TI Negative pressure dressings and the impact on pain management on
   thoracic incisions in patients undergoing oesophagectomy: a pilot study
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE esophagectomy; general surgery; pain; postoperative; thoracotomy
ID WOUND THERAPY; RISK
AB BackgroundPain control is recognised as a crucial post-operative measure for patients undergoing oesophagectomy with a thoracotomy incision for oesophageal cancer, where ineffective breathing due to pain is directly correlated with increased morbidity. The analgesic benefits of negative pressure wound therapy (NPWT) appear to be a relatively new and emerging finding. This pilot study aims to investigate the effects of NPWT on post-operative pain control and determine the feasibility of a larger trial.MethodTen consecutive patients undergoing oesophagectomy were prospectively enrolled to have a PREVENA Incision Management System placed over a closed thoracotomy wound. This dressing was changed at post-operative day 5 and removed after day 10. Post-operative morbidity was recorded and analgesia was prescribed by the Acute Pain Service who were blinded to the study aims. Analgesia requirements were recorded in oral morphine equivalents (OME) and compared to 30 patients that had previously undergone oesophagectomy via thoracotomy.ResultsOne patient was withdrawn from the study and there was no significant differences in patient demographics. The study group had less average daily analgesia requirements and reduced overall reported pain. Patients in the study group were less likely to develop pneumonia (44% and 57%) and less likely to require re-operation for complications of their surgery (0% and 10%).ConclusionThis pilot study shows reduced post-operative analgesia requirements and reduced morbidity when using NPWT over a closed thoracotomy wound, and affirms the feasibility of a future randomized control trial.
   Using negative pressure wound therapy dressing over a thoracotomy wound to improve post-operative pain control in patients undergoing oesophagectomy. Pilot study with results demonstrating a trend toward improved post-operative outcomes.image
C1 [Pavan, Fiona; Tan, Jed; Vu, Joseph; Martin, Sarah] Monash Hlth, Dept Gen Surg, Melbourne, Vic, Australia.
   [Gamage, Sankalpa] Monash Univ, Dept Med Nursing & Hlth Sci, Melbourne, Vic, Australia.
   [Cashin, Paul; Low, Liang; Martin, Sarah] Monash Hlth, Dept Upper GI & Hepatobiliary Surg, Melbourne, Vic, Australia.
   [Cashin, Paul] Jessie McPherson Private Hosp, Med Serv, Melbourne, Vic, Australia.
   [Cashin, Paul; Low, Liang; Martin, Sarah] Monash Univ, Dept Surg, Melbourne, Vic, Australia.
   [Pavan, Fiona] Monash Hlth, Dept Gen Surg, 246 Clayton Rd, Clayton, Vic 3168, Australia.
C3 Monash Health; Monash University; Monash Health; Jessie McPherson
   Private Hospital; Monash University; Monash Health
RP Pavan, F (通讯作者)，Monash Hlth, Dept Gen Surg, 246 Clayton Rd, Clayton, Vic 3168, Australia.
EM fiona.pavan@gmail.com
CR [Anonymous], OPIOID EQUIANALGESIA
   [Anonymous], OVERVIEW PERIPHERAL
   Australian Government- Human Services, MEDICARE STAT
   Chadi SA, 2014, DIS COLON RECTUM, V57, P999, DOI 10.1097/DCR.0000000000000161
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   Gunatilake RP, 2017, AJP REP, V7, pE151, DOI 10.1055/s-0037-1603956
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   Soto RG, 2003, ANN THORAC SURG, V75, P1349, DOI 10.1016/S0003-4975(02)04647-7
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Yu LL, 2018, AM J OBSTET GYNECOL, V218, P200, DOI 10.1016/j.ajog.2017.09.017
NR 12
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD DEC
PY 2023
VL 93
IS 12
BP 2870
EP 2874
DI 10.1111/ans.18759
EA DEC 2023
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EJ3X7
UT WOS:001125476800001
PM 38093461
OA Bronze
DA 2026-07-24
ER
PT J
AU Singh, PK
   Sethi, MK
   Mishra, TS
   Kumar, P
   Ali, SM
   Sasmal, PK
   Mishra, SS
AF Singh, Pradeep Kumar
   Sethi, Mahesh Kumar
   Mishra, Tushar Subhadarshan
   Kumar, Pankaj
   Ali, S. Manwar
   Sasmal, Prakash Kumar
   Mishra, Swastik Sourav
TI Comparison of surgical site infection (SSI) between negative pressure
   wound therapy (NPWT) assisted delayed primary closure and conventional
   delayed primary closure in grossly contaminated emergency abdominal
   surgeries: a randomized controlled trial
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE SSI; NPWT; Delayed primary closure; Dirty wound
ID RISK-FACTORS
AB PurposeNPWT has been tried in many surgical fields, including colorectal, thoracic, vascular, and non-healing wounds, for the prevention of SSI. However, its efficacy in the prevention of SSI-grade IV closed abdominal wounds is yet to be explored.MethodsAll patients with grade IV abdominal wounds were included in the study. They were randomized into the conventional arm and the VAC arm after confirming the diagnosis intra-operatively. The sheath was closed, and the skin was laid open in the postoperative period. In the VAC arm, the NPWT dressing was applied on postoperative day (POD)-1 and removed on POD-5. In the conventional arm, only regular dressing was done postoperatively. The skin was closed with a delayed primary intention on POD-5 in both arms. The sutures were removed after 7 to 10 days of skin closure.ResultsThe rate of SSI (10% in the VAC arm vs. 37.5% in the conventional arm, p-value = 0.004) was significantly lower in the VAC arm, as were the rates of seroma formation (2.4% in the VAC arm vs. 20% in the conventional arm, p = 0.014) and wound dehiscence (7.3% vs. 30%, p = 0.011). The conventional arm had a significant delay in skin closure beyond POD5 due to an increased rate of SSI, which also led to a prolonged hospital stay (5 days in the VAC arm vs. 6.5 days in the conventional arm, p-value = 0.005).ConclusionThe VAC dressing can be used routinely in grade IV closed abdominal wounds to reduce the risk of SSI and wound dehiscence.
C1 [Singh, Pradeep Kumar; Sethi, Mahesh Kumar; Mishra, Tushar Subhadarshan; Kumar, Pankaj; Ali, S. Manwar; Sasmal, Prakash Kumar; Mishra, Swastik Sourav] AIIMS Bhubaneswar, Dept Gen Surg, Bhubaneswar, Odisha, India.
C3 All India Institute of Medical Sciences (AIIMS) Bhubaneswar
RP Sethi, MK (通讯作者)，AIIMS Bhubaneswar, Dept Gen Surg, Bhubaneswar, Odisha, India.
EM surg_pradeep@aiimsbhubaneswar.edu.in; maheshsethi949@gmail.com;
   surg_tushar@aiimsbhubaneswar.edu.in;
   surg_pankaj@aiimsbhubaneswar.edu.in;
   surg_manwar@aiimsbhubaneswar.edu.in;
   surg_prakash@aiimsbhubaneswar.edu.in; swmswastik@gmail.com
RI Singh, Pradeep/AGI-4972-2022; MISHRA, TUSHAR/KFS-1512-2024
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NR 37
TC 5
Z9 8
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD DEC 27
PY 2023
VL 409
IS 1
AR 19
DI 10.1007/s00423-023-03202-x
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DK1G2
UT WOS:001131833200001
PM 38150073
OA hybrid
DA 2026-07-24
ER
PT J
AU Biermann, N
   Taeger, CD
   Schatz, V
   Eigenberger, A
   Prantl, L
   Felthaus, O
AF Biermann, Niklas
   Taeger, Christian D.
   Schatz, Valentin
   Eigenberger, Andreas
   Prantl, Lukas
   Felthaus, Oliver
TI The influence of negative pressure wound therapy on bacterial and fungal
   growth
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PREVALENCE; DRESSINGS; CULTURE; BURDEN
AB Background: The use of negative pressure wound therapy (NPWT) in superinfected wounds is controversial. The mechanism of action is unclear, but recent studies have shown lower atmospheric oxygen levels within the dressing. Therefore, different oxygen-favoring bacteria and fungi might benefit or face impaired thriving attached to a standard NPWT-device. After 48 hours, colonies were separately harvested from the agar and foam. Optical density (OD) was obtained in order to Results: For all tested microorganisms, no overall significant differences were found compared to controls. Subanalysis showed lower OD levels from the agar beneath Conclusion: NPWT removed bacteria and fungi from the wound surface but accumulation is found within the foam. The use of NPWT showed no influence on bacterial or fungal growth selection. With superinfected wounds, the use of NPWT should thoroughly be evaluated as toxins and virulence factors may not fully be evacuated.
C1 [Biermann, Niklas; Taeger, Christian D.; Eigenberger, Andreas; Prantl, Lukas; Felthaus, Oliver] Univ Hosp Regensburg, Dept Plast Hand and Reconstruct Surg, Regensburg, Germany.
   [Schatz, Valentin] Univ Hosp Regensburg, Dept Med Microbiol & Hyg, Regensburg, Germany.
   [Biermann, Niklas] Regensburg Univ Hosp UKR, Dept Plast Hand & Reconstruct Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
C3 University of Regensburg; University of Regensburg; University of
   Regensburg
RP Biermann, N (通讯作者)，Regensburg Univ Hosp UKR, Dept Plast Hand & Reconstruct Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
EM niklas.biermann@ukr.de
RI Felthaus, Oliver/K-5467-2015; Prantl, Lukas/AAM-1848-2021
OI Eigenberger, Andreas/0000-0002-2141-8786; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 28
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD NOV
PY 2023
VL 32
IS 4
BP 613
EP 617
DI 10.1016/j.jtv.2023.06.010
EA DEC 2023
PG 5
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA DN4M8
UT WOS:001132712500001
PM 37414709
DA 2026-07-24
ER
PT J
AU Jenkins, S
   Komber, M
   Mattam, K
   Briffa, N
AF Jenkins, Sam
   Komber, Mohamed
   Mattam, Kavitha
   Briffa, Norman
TI Negative pressure wound therapy in patients with diabetes undergoing
   left internal thoracic artery harvest: A randomized control trial
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 102nd Annual Meeting of the American-Association-for-Thoracic-Surgery
   (AATS)
CY MAY 14-17, 2022
CL Boston, MA
SP Amer Assoc Thorac Surg
DE Key Words; coronary artery bypass graft; incisional tive pressure wound
   therapy; left internal thoracic artery; near-infrared spectroscopy;
   randomized control trial; cal site infection
ID NEAR-INFRARED SPECTROSCOPY; SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED
   CLOSURE; TISSUE OXYGEN-SATURATION; STAPHYLOCOCCUS-AUREUS; COLORECTAL
   SURGERY; NASAL CARRIAGE; RISK; WALL
AB Background: Patients with diabetes undergoing CABG are at risk of wound tion. Incisional negative pressure wound therapy has been shown to be effective decreasing incidence of infection in high-risk wounds. Near infrared spectroscopy (NIRS) can be used to assess wound oxygenation and low values can infection. Objectives: To evaluate utility of NIRS to assess wound oxygenation, to fect of sternotomy, left internal thoracic artery harvest, and wound dressing wound edge oxygenation. Methods: In this blinded randomized control trial, patients with diabetes ing isolated coronary artery bypass grafting with a left internal thoracic artery randomized to receive either incisional negative pressure wound therapy or a standard dressing. NIRS measurements were made on the left upper trol), and left and right parasternal regions on day -1 (preoperative), day 5, after surgery. Results were analyzed using repeated measures parametric methods. Results: Eighty patients with diabetes were recruited, 40 to the incisional pressure wound therapy group and 40 to the standard dressing group. NIRS readings dropped significantly in all patients by day 5 and partially by week 6. In both groups, there was no difference between readings on the right. At all time points and on both sides, there was no difference in readings tween patients in the 2 groups. Conclusions: NIRS can be used to assess oxygenation adjacent to a sternotomy wound. Adjusted tissue oxygen levels change with time after sternotomy internal thoracic artery harvest in patients with diabetes. Wound dressing does not influence day 5 wound edge oxygenation. (J Thorac Cardiovasc 2024;167:256-68)
C1 [Jenkins, Sam; Briffa, Norman] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, England.
   [Komber, Mohamed; Mattam, Kavitha; Briffa, Norman] Sheffield Teaching Hosp, NHS Fdn Trust, Dept Cardiothorac Surg, Sheffield, England.
   [Briffa, Norman] Sheffield Teaching Hosp, Northern Gen Hosp, Dept Cardiothorac Surg, Chesterfield Wing,Herries Rd, Sheffield S5 7AU, S Yorkshire, England.
C3 University of Sheffield; University of Sheffield; Oxford University
   Hospitals NHS Foundation Trust; Northern General Hospital; University of
   Sheffield
RP Briffa, N (通讯作者)，Sheffield Teaching Hosp, Northern Gen Hosp, Dept Cardiothorac Surg, Chesterfield Wing,Herries Rd, Sheffield S5 7AU, S Yorkshire, England.
EM n.briffa@sheffield.ac.uk
RI ; Briffa, Norman/N-5386-2014
OI Jenkins, Sam/0000-0003-1941-2892; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 33
TC 4
Z9 4
U1 1
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD JAN
PY 2024
VL 167
IS 1
BP 256
EP 268
DI 10.1016/j.jtcvs.2022.01.060
EA DEC 2023
PG 13
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA DT0X3
UT WOS:001134217700001
PM 35550716
DA 2026-07-24
ER
PT J
AU Morani, Z
   Mehta, A
   Parul, F
   Huang, HL
   Khan, MR
   Javaid, N
   Ninan, RS
   Wireko, AA
   Muhammed, L
   Siddiqui, FA
AF Morani, Zoya
   Mehta, Aashna
   Parul, Fnu
   Huang, Helen
   Khan, Mohammad Raza
   Javaid, Nialish
   Ninan, Rachael Suzanne
   Wireko, Andrew Awuah
   Muhammed, Luqman
   Siddiqui, Fatima Aman
TI Benefits of negative pressure wound therapy with fat migration during
   revisional total hip arthroplasty in an obese patient: A case report
SO MEDICINE
LA English
DT Article
DE negative pressure wound therapy; obesity; orthopedic surgery; revisional
   arthroplasty; total hip replacement
ID ADIPONECTIN
AB Introduction: A 38-year-old African American woman presented with right hip pain and movement restriction. Her medical history included a right hip and knee arthroplasty 10 years prior, history of Slipped Capital Femoral Epiphysis and osteonecrosis of the hip. Preoperative assessment was significant for multiple comorbidities such as obesity (BMI > 38), hypertension, asthma.Patient concerns: The patient presented with right hip pain, rated 7/10, and restricted hip flexion, adduction, and abduction.Diagnosis: Recent imaging showed eccentric deterioration of the polyethylene lining of her prosthesis, acetabular hypertrophy on her right hip prosthesis, and chronic deformity of the pubic bone.Interventions: Based on these findings, a revisional total hip arthroplasty was performed. After the surgical procedure, the WoundVAC and the percutaneous drain were applied outside the tensor fascia lata to reduce seroma and hematoma formation. Postoperative pain control, antibiotics and DVT prophylaxis were given. On post-op day 3, an irrigation and debridement with delayed primary wound closure was performed under sterile conditions.Outcomes: On postoperative assessment, the wound demonstrated adequate healing without any signs of infection. Sutures and staples were removed 4 weeks post-op. Upon palpation there was no edema, effusions, temperature changes, tenderness. Clinical inspection revealed symmetrical alignment of the pelvis and hips. Range of motion testing revealed restriction beyond 80 degrees upon flexion and beyond 5 degrees of adduction and 10 degrees of abduction. The surgical site was noted to be healed at 6 weeks post-op. The patient continued to do well to date, without exacerbations.Conclusion: Obesity increases the risk of post-operative complications and wound healing failure. Therefore, Vacuum-assisted wound closure (WoundVAC), a type of negative pressure wound therapy, was applied outside the tensor fascia lata post-operatively, where the surgical incision was made. Negative pressure wound therapy facilitates wound healing by stimulating angiogenesis and promoting granulation tissue formation, which in turn can reduce the risk of surgical site infection in obese patients undergoing total hip arthroplasty. Highlighted is the mechanism of fat migration in the promotion of wound healing after preoperative weight loss and exercise.
C1 [Morani, Zoya; Muhammed, Luqman] Washington Univ Hlth & Sci, San Pedro, Belize.
   [Mehta, Aashna; Ninan, Rachael Suzanne] Univ Debrecen, Fac Med, Debrecen, Hungary.
   [Parul, Fnu] Pandit Bhagwat Dayal Sharma Post Grad Inst Med Sc, Rohtak, India.
   [Huang, Helen] Univ Med & Hlth Sci, Royal Coll Surg Ireland, Dublin, Ireland.
   [Khan, Mohammad Raza] Humboldt Pk Hlth, Chicago, IL USA.
   [Javaid, Nialish; Siddiqui, Fatima Aman] Windsor Univ, Sch Med, Cayon, St Kitts & Nevi.
   [Wireko, Andrew Awuah] Sumy State Univ, Sumy, Ukraine.
C3 University of Debrecen; Pt. B.D. Sharma Post Graduate Institute of
   Medical Sciences (PGIMS), Rohtak; Royal College of Surgeons in Ireland -
   RCSI; Ministry of Education & Science of Ukraine; Sumy State University
RP Wireko, AA (通讯作者)，Sumy State Univ, UA-40000 Sumy, Ukraine.
EM Zoya.morani@gmail.com; aashna.m19@gmail.com; gindraparul@gmail.com;
   HelenHuang@rcsi.ie; MohammadRazaKhan9@gmail.com; Nialishj@gmail.com;
   rachael.ninan@gmail.com; andyvans36@yahoo.com; luqman.mh@gmail.com;
   fatima.siddiqui@student.windsor.edu
RI WIREKO, ANDREW AWUAH/ABD-3005-2021
OI WIREKO, ANDREW AWUAH/0000-0003-2380-2949
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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   Robert N, 2017, ORTHOP TRAUMATOL-SUR, V103, pS99, DOI 10.1016/j.otsr.2016.04.018
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NR 15
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC 29
PY 2023
VL 102
IS 52
AR e36726
DI 10.1097/MD.0000000000036726
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DT2R2
UT WOS:001134264400069
PM 38206741
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Xu, JP
   Hua, Y
   Lei, J
   Peng, XF
   Cheng, L
   Jiang, QX
   Yang, J
AF Xu, Jipeng
   Hua, Ye
   Lei, Jun
   Peng, Xuefei
   Cheng, Lu
   Jiang, Qixue
   Yang, Jun
TI Effects of skin flap grafting combined with vacuum sealing drainage on
   ulcer area, pain level, and serum inflammation in diabetic foot patients
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Skin flap grafting; vacuum sealing drainage; diabetic foot; ulcer area;
   serum inflammation
ID PRESSURE WOUND THERAPY
AB Objective: To study the effects of skin flap grafting combined with vacuum sealing drainage (VSD) on ulcer area, pain level and serum inflammation in patients with diabetic foot (DF). Methods: In this retrospective study, 121 patients with DF who were treated in the Affiliated Hospital of Xinyang Vocational and Technical College between April 2018 and April 2022 were included as study subjects, including 50 cases receiving skin flap grafting (control group) and 71 cases receiving skin flap grafting combined with VSD (research group). Information on clinical efficacy, survival rate of the grafted flap, amputation and complications, ulcer area, rehabilitation (granulation tissue formation time, ulcer wound healing time), pain level (Visual Analogue Scale [VAS]), and serum inflammatory factors (interleukin [IL]-6, tumor necrosis factor [TNF]-alpha, and C-reactive protein [CRP]) were collected for comparative analyses. Univariate and multivariate analyses were conducted to screen the risk factors for patients' prognosis. Results: The overall response rate and the survival rate of the grafted flap in the research group were markedly higher compared with the control group, while the amputation rate was significantly lower (all P<0.05). Besides, the research group exhibited an evidently smaller post-treatment ulcer area, lower VAS, IL-6, TNF-alpha and CRP levels, and shorter granulation tissue formation time and ulcer wound healing time than the control group (all P<0.05). Neither group of patients experienced significant complications. The use of skin flap grafting + VSD was a protective factor for postoperative outcome. Conclusions: Skin flap grafting combined with VSD is effective in treating DF patients, which can validly reduce ulcer area and inhibit serum inflammation after treatment, thus accelerating rehabilitation.
C1 [Xu, Jipeng; Cheng, Lu; Jiang, Qixue] Xinyang Vocat & Tech Coll, Dept Oncol, Affiliated Hosp, Xinyang 464000, Henan, Peoples R China.
   [Hua, Ye; Lei, Jun; Peng, Xuefei; Yang, Jun] Xinyang Vocat & Tech Coll, Affiliated Hosp, Dept Orthoped & Dermatol, Xinyang 464099, Henan, Peoples R China.
RP Yang, J (通讯作者)，Xinyang Vocat & Tech Coll, Affiliated Hosp, Dept Orthoped & Dermatol, Xinyang 464099, Henan, Peoples R China.
EM 280941190@qq.com
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NR 27
TC 4
Z9 6
U1 0
U2 6
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2023
VL 15
IS 12
BP 6939
EP 6948
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA EC1Z6
UT WOS:001136633900003
PM 38187004
DA 2026-07-24
ER
PT J
AU Wang, C
   Li, R
   Su, XP
   Zhang, JX
   Liu, ZZ
AF Wang, Chao
   Li, Rui
   Su, Xiangpeng
   Zhang, Jixun
   Liu, Zhenzhong
TI Effect of hydrocolloid dressings on preventing air leakage when applying
   negative pressure wound therapy to the perineum, buttocks, and
   sacrococcygeal region
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE air leakage; hydrocolloid dressings; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; DELIVERY
AB Maintaining a vacuum when applying negative pressure wound therapy (NPWT) is the key to its function, which is a challenge in the perineum, buttocks, and sacrococcygeal region. A retrospective cohort study was conducted to assess the effect of hydrocolloid dressings on preventing air leakage when applying NPWT in these regions. There were 61 patients in Group A (without the aid of hydrocolloid dressings) and 65 patients in Group B (with the aid of hydrocolloid dressings). The hydrocolloid dressing-assisted NPWT significantly reduced the incidence of air leakage compared with conventional NPWT placement (24.6% vs. 7.7%; risk ratio, 3.20; 95% confidence interval, 1.24-8.27; p = 0.009), while decreasing the number of open NPWT applications (2.2 vs. 1.7; difference, 0.43; 95% confidence interval, 0.19-0.66; p < 0.001), shortening hospital stays (20.1 vs. 16.1; difference, 4.07; 95% confidence interval, 1.68-6.46; p = 0.01), and reducing the incidence of adverse skin events (18.0% vs. 4.6%; risk ratio, 3.91; 95% confidence interval, 1.14-13.34; p = 0.017). These findings support the routine use of hydrocolloid dressing-assisted NPWT placement in the perineum, buttocks, and sacrococcygeal region.
C1 [Wang, Chao; Zhang, Jixun; Liu, Zhenzhong] Second Hosp Shandong Univ, Dept Burn & Plast Surg, Jinan, Peoples R China.
   [Li, Rui] Second Hosp Shandong Univ, Dept Emergency, Jinan, Peoples R China.
   [Su, Xiangpeng] Shandong Univ, Cheeloo Coll Med, Jinan, Peoples R China.
   [Liu, Zhenzhong] Second Hosp Shandong Univ, Dept Burn & Plast Surg, Jinan 250033, Shandong, Peoples R China.
C3 Shandong University; Shandong University; Shandong University; Shandong
   University
RP Liu, ZZ (通讯作者)，Second Hosp Shandong Univ, Dept Burn & Plast Surg, Jinan 250033, Shandong, Peoples R China.
EM 200462011912@sdu.edu.cn
RI LI, RUI/NQF-9317-2025
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NR 32
TC 0
Z9 0
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN
PY 2024
VL 32
IS 1
BP 74
EP 79
DI 10.1111/wrr.13136
EA JAN 2024
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA GF4R0
UT WOS:001137017900001
PM 38127338
OA Bronze
DA 2026-07-24
ER
PT J
AU Marais, LC
   Hungerer, S
   Eckardt, H
   Zalavras, C
   Obremskey, WT
   Ramsden, A
   Mcnally, MA
   Morgenstern, M
   Metsemakers, WJ
AF Marais, Leonard C.
   Hungerer, Sven
   Eckardt, Henrik
   Zalavras, Charalampos
   Obremskey, William T.
   Ramsden, Alex
   Mcnally, Martin A.
   Morgenstern, Mario
   Metsemakers, Willem-Jan
CA FRI Consensus Grp
TI Key aspects of soft tissue management in fracture-related infection:
   recommendations from an international expert group
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Review; Early Access
DE Fracture-related infection; Soft tissue closure; Soft tissue cover; Soft
   tissue defects, flap; Negative pressure wound therapy; Fasciocutaneous
   flap; Muscle flap; Fracture; Infection
ID PRESSURE WOUND THERAPY; OPEN TIBIAL FRACTURES; VACUUM-ASSISTED CLOSURE;
   MUSCLE FLAP COVERAGE; LOWER-LIMB; CHRONIC OSTEOMYELITIS; INITIAL
   MANAGEMENT; TRAUMATIC WOUNDS; BACTERIAL LOAD; BLOOD-FLOW
AB A judicious, well-planned bone and soft tissue debridement remains one of the cornerstones of state-of-the-art treatment of fracture-related infection (FRI). Meticulous surgical excision of all non-viable tissue can, however, lead to the creation of large soft tissue defects. The management of these defects is complex and numerous factors need to be considered when selecting the most appropriate approach. This narrative review summarizes the current evidence with respect to soft tissue management in patients diagnosed with FRI. Specifically we discuss the optimal timing for tissue closure following debridement in cases of FRI, the need for negative microbiological culture results from the surgical site as a prerequisite for definitive wound closure, the optimal type of flap in case of large soft tissue defects caused by FRI and the role of negative pressure wound therapy (NPWT) in FRI. Finally, recommendations are made with regard to soft tissue management in FRI that should be useful for clinicians in daily clinical practice.
C1 [Marais, Leonard C.] Univ KwaZulu Natal, Sch Clin Med, Dept Orthopaed, Durban, South Africa.
   [Hungerer, Sven] Murnau Germany & Paracelsus Med Univ PMU Salzburg, Trauma Ctr Murnau, Dept Joint Surg & Arthroplasty, Salzburg, Austria.
   [Eckardt, Henrik; Morgenstern, Mario] Univ Hosp Basel, Dept Orthopaed & Trauma Surg, Basel, Switzerland.
   [Zalavras, Charalampos] Univ Southern Calif, Keck Sch Med, Dept Orthopaed Surg, Los Angeles, CA USA.
   [Obremskey, William T.] Vanderbilt Univ Sch Med, Dept Orthopaed Surg & Rehabil, Nashville, TN USA.
   [Ramsden, Alex; Mcnally, Martin A.] Oxford Univ Hosp, Nuffield Orthopaed Ctr, Bone Infect Unit, Oxford, England.
   [Metsemakers, Willem-Jan] Univ Hosp Leuven, Dept Trauma Surg, Leuven, Belgium.
C3 University of Kwazulu Natal; University of Basel; University of Southern
   California; Vanderbilt University; Nuffield Orthopaedic Centre; KU
   Leuven; University Hospital Leuven
RP Metsemakers, WJ (通讯作者)，Univ Hosp Leuven, Dept Trauma Surg, Leuven, Belgium.
EM willem-jan.metsemakers@uzleuven.be
RI Hungerer, Sven/H-5818-2013; Metsemakers, Willem-Jan/F-8647-2016;
   Morgenstern, Mario/AAL-8268-2020; Marais, Leonard Charles/AIC-4689-2022;
   Obremskey, William/HRA-4704-2023
OI Eckardt, Henrik/0000-0001-5842-7603; Metsemakers,
   Willem-Jan/0000-0002-4114-9093; Morgenstern, Mario/0000-0001-5108-0731; 
FU <bold>Members of the FRI consensus group:</bold> Willem-Jan Metsemakers,
   Department of Trauma Surgery, University Hospitals Leuven, Leuven,
   Belgium. William T. Obremskey, Department of Orthopaedic Surgery and
   Rehabilitation, Vanderbilt University Medical C; University Hospitals
   Leuven, Leuven, Belgium; Department of Orthopaedic Surgery and
   Rehabilitation; Vanderbilt University Medical Center, Nashville, TN,
   United States of America; Bone Infection Unit, Nuffield Orthopaedic
   Centre, Oxford University Hospitals, Oxford, United Kingdom; CHUV,
   Lausanne, Switzerland; Department of Laboratory Medicine, University
   Hospitals Leuven, Belgium; Department of Orthopaedic and Trauma Surgery,
   University Hospital Basel, Switzerland; NYU Langone Orthopedic Hospital,
   New York, NY, USA; Limb Lengthening amp; Complex Reconstruction Service,
   New York, NY, USA; University of Utrecht, University Medical Center
   Utrecht, Utrecht, The Netherlands; Paracelsus Medical University (PMU)
   Salzburg, Austria; Virginia Commonwealth University, USA; Richard Kuehl,
   Department of Infectious Diseases and Hospital Epidemiology, University
   Hospital of Basel, Switzerland; Department of Orthopaedics, School of
   Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa;
   Department of Orthopaedic Surgery, University Hospitals of North
   Midlands, Stoke-on-Trent, United Kingdom; Mario Morgenstern, Department
   of Orthopaedic and Trauma Surgery, University Hospital Basel,
   Switzerland; AO Research Institute Davos, Switzerland; Department of
   Orthopaedic Surgery, Keck School of Medicine, University of Southern
   California, Los Angeles, USA; Gustave Dron Hospital, University of
   Lille, France; Berlin Institute of Health, Germany; Erasmus University
   Medical Centre, Rotterdam, The Netherlands; Interdisciplinary Unit for
   Orthopedic Infections, Kantonsspital Baselland
FX The source of funding with respect to hosting the consensus meeting 2018
   was the AO Foundation (AOTC System and AOTrauma). Travel costs for the
   Orthopaedic Trauma Association members were met by the Orthopaedic
   Trauma Association. Open access publication was funded by the AO
   Foundation.r <BOLD>Members of the FRI consensus group:</BOLD> Willem-Jan
   Metsemakers, Department of Trauma Surgery, University Hospitals Leuven,
   Leuven, Belgium. William T. Obremskey, Department of Orthopaedic Surgery
   and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN,
   United States of America. Martin A. McNally, The Bone Infection Unit,
   Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, United
   Kingdom. Bridget L. Atkins, The Bone Infection Unit, Nuffield
   Orthopaedic Centre, Oxford University Hospitals, Oxford, United Kingdom.
   Olivier Borens, Orthopedic Department of Septic Surgery,
   Orthopaedic-Trauma Unit, Department for the Musculoskeletal System,
   CHUV, Lausanne, Switzerland. Melissa Depypere, Department of Laboratory
   Medicine, University Hospitals Leuven, Belgium. Henrik Eckardt,
   Department of Orthopaedic and Trauma Surgery, University Hospital Basel,
   Switzerland. Kenneth A. Egol, Department of Orthopedic Surgery, NYU
   Langone Orthopedic Hospital, New York, NY, USA. Austin T. Fragomen,
   Hospital for Special Surgery, Limb Lengthening & Complex Reconstruction
   Service, New York, NY, USA. Jolien Onsea, Department of Trauma Surgery,
   University Hospitals Leuven, Leuven, Belgium. Geertje A. M. Govaert,
   Department of Trauma Surgery, University of Utrecht, University Medical
   Center Utrecht, Utrecht, The Netherlands. Sven Hungerer, Department of
   Joint Surgery and Arthroplasty, Trauma Center Murnau, Murnau Germany and
   Paracelsus Medical University (PMU) Salzburg, Austria. Stephen L. Kates,
   Department of Orthopaedic Surgery, Virginia Commonwealth University,
   USA. Richard Kuehl, Department of Infectious Diseases and Hospital
   Epidemiology, University Hospital of Basel, Switzerland. Leonard C.
   Marais, Department of Orthopaedics, School of Clinical Medicine,
   University of KwaZulu-Natal, Durban, South Africa. Ian Mcfadyen,
   Department of Orthopaedic Surgery, University Hospitals of North
   Midlands, Stoke-on-Trent, United Kingdom. Mario Morgenstern, Department
   of Orthopaedic and Trauma Surgery, University Hospital Basel,
   Switzerland. T. Fintan Moriarty, AO Research Institute Davos,
   Switzerland. Alex Ramsden, The Bone Infection Unit, Nuffield Orthopaedic
   Centre, Oxford University Hospitals, Oxford, United Kingdom. Michael
   Raschke, Department of Trauma Surgery, University Hospital of Munster,
   Germany. R. Geoff Richards, AO Research Institute Davos, Switzerland.
   Carlos Sancineto, Department of Orthopaedics, Hospital Italiano de
   Buenos Aires, Buenos Aires, Argentina. Charalampos Zalavras, Department
   of Orthopaedic Surgery, Keck School of Medicine, University of Southern
   California, Los Angeles, USA. Eric Senneville, Department of Infectious
   Diseases, Gustave Dron Hospital, University of Lille, France. Andrej
   Trampuz, Center for Musculoskeletal Surgery, Charite-Universitatsmedizin
   Berlin, corporate member of Freie Universitat Berlin,
   Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Germany.
   Michael H. J. Verhofstad, Department of Trauma Surgery, Erasmus
   University Medical Centre, Rotterdam, The Netherlands. Werner Zimmerli,
   Interdisciplinary Unit for Orthopedic Infections, Kantonsspital
   Baselland, Rheinstrasse 26, 4410, Liestal, Switzerland.
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NR 77
TC 16
Z9 21
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD 2023 NOV 3
PY 2023
DI 10.1007/s00402-023-05073-9
EA NOV 2023
PG 10
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA EF7O4
UT WOS:001137575400002
PM 37921993
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Ning, T
   Guo, HH
   Song, QW
   Mei, SW
   Wang, H
   Yu, HY
AF Ning, Tao
   Guo, Huihui
   Song, Qiwei
   Mei, Siwei
   Wang, Hao
   Yu, Haiyang
TI A Modified Negative Pressure Wound Therapy Reduces the Occurrence of
   Tension Blisters Around Negative Pressure Dressings
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Background center dot To date, there is no effective solution for preventing the formation of blisters around negative-pressure wound dressings. In this study, we aim to address this problem and identify techniques to improve the negative-pressure drainage technique.
   Methods center dot A total of 129 patients from 2021.11 to 2022.11 who were previously treated in Fuyang People's Hospital were included in this retrospective analysis. All patients had negative-pressure drainage dressings applied to their wounds after undergoing thorough wound debridement. The patients were divided into the following groups: a traditional treatment group and a modified treatment group. The traditional treatment group comprised 60 patients who received negative-pressure wound therapy (NPWT) and a modified treatment group comprised 69 patients who received NPWT plus Vaseline gauze. The dressing coverage area, wound location, incidence of blisters around the dressing 3 days after NPWT, wound infection rate, and length of hospitalization were recorded. The incidence of blisters, wound infection rate, and wound location in the 2 groups were included as the categorical data and were compared using a chi-squared test. The dressing coverage area and length of hospitalization in the 2 groups were included as the quantitative data and were compared using an independent samples t test or with the Mann-Whitney test if the data were abnormally distributed.
   Results center dot The incidence rates of blisters in the traditional and modified treatment groups were 33.3% (20/60) and 13.0% (9/69), respectively, displaying a statistically significant difference (chi(2) = 7.581, P = .006). The infection rates of the 2 groups were 38.3% (23/60) and 20.3% (14/69), respectively, showing a statistically significant difference (chi(2) = 5.108; P = .024). The lengths of hospitalization in the 2 groups were 26.05 +/- 14.74 days and 18.17 +/- 7.54 days, respectively, showing a statistically significant difference (t = 3.892; P = .000). The dressing coverage areas were 150 cm(2) (88.75 cm(2), 600 cm(2)) and 150 cm(2) (124 cm(2), 600 cm(2)), respectively, showing no statistical difference (P = .759).
   Conclusion center dot Modified NPWT can effectively reduce the incidence of blisters, length of hospitalization, and infection rate of patients.
C1 [Ning, Tao; Guo, Huihui; Song, Qiwei; Mei, Siwei; Wang, Hao; Yu, Haiyang] Fuyang Peoples Hosp, Dept Orthopaed Surg, Fuyang, Peoples R China.
RP Ning, T (通讯作者)，Fuyang Peoples Hosp, Dept Orthopaed Surg, Fuyang, Peoples R China.
EM doctorning87@163.com
RI Yu, Haiyang/JVO-2592-2024; guo, huihui/GYQ-8331-2022
FU Bengbu Medical College Project Fund [2020byzd347]; Clinical Science
   Foundation of Anhui Medical University [2022xkj225]; Fuyang city health
   commission project fund [FY2021-027]
FX This work was supported by the Bengbu Medical College Project Fund
   (NO.2020byzd347) Clinical Science Foundation of Anhui Medical University
   (NO.2022xkj225), and Fuyang city health commission project fund
   (NO.FY2021-027)
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NR 19
TC 0
Z9 0
U1 0
U2 0
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD NOV-DEC
PY 2023
VL 29
IS 8
BP 540
EP 544
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EG1E0
UT WOS:001137669200090
PM 37678851
DA 2026-07-24
ER
PT J
AU Ning, T
   Zha, ZG
AF Ning, Tao
   Zha, Zhen-Gang
TI Treatment of Morel-Lavallee Lesions (MLLs) with Mesh Incisions Combined
   with Quilting Sutures and Negative Pressure Wound Therapy (NPWT)
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
AB Purpose center dot The objective of this retrospective study was to evaluate the clinical effects of a novel treatment approach for Morel-Lavallee lesions (MLL) using a combination of suturing techniques and Negative Pressure Wound Therapy (NPWT) with mesh incisions. To summarize the clinical effects of a combination of suturing techniques and (Negative Pressure Wound Therapy) NPWT on the wall of Morel-Lavallee lesions ( MLL) fibrotic pseudocapsules with mesh incisions in the treatment of MLLs. A retrospective analysis was performed on MLL patients from April 2017 to March 2021.
   Methods center dot This a retrospective case-control study and thirteen MLL patients were included in this retrospective analysis conducted between April 2017 and March 2021, who were treated with mesh incisions on the wall of the pseudocapsule, quilting suturing to degloved soft tissues, and NPWT. Physical examination, MRI, or ultrasound before surgery confirmed the diagnosis. Wound healing, secondary infection, recurrence, visual analog scale (VAS) scores before and after surgery, and skin and soft tissue condition were observed and evaluated.
   Results center dot The combination of mesh incisions, quilting sutures, and NPWT led to successful wound healing in 11 out of 13 cases without recurrent hematoma or secondary infection. Visual analog scale (VAS) scores significantly decreased after the operation, and the aesthetic and tactile qualities of the injured area improved. One case of skin and soft tissue necrosis infection before the operation, which healed after second-stage full-thickness skin grafting, 1 case healed after a dressing change, and the remaining 11 cases had wounds that healed by the first stage without secondary infection or recurrent hematoma formation. VAS scores decreased significantly after the operation, the appearance of the injured area was as expected, and the skin feel and elasticity recovered satisfactorily.
   Conclusion center dot The study demonstrates that the mesh incision technique, along with mattress sutures and NPWT, presents a feasible and effective approach for treating MLL with fibrotic pseudocapsules. This could shorten healing times, reduce risk of complications, and improve patient satisfaction.
C1 [Ning, Tao; Zha, Zhen-Gang] Jinan Univ, Affiliated Hosp 1, Inst Orthoped Dis, Guangzhou, Guangdong, Peoples R China.
   [Ning, Tao; Zha, Zhen-Gang] Jinan Univ, Affiliated Hosp 1, Dept Bone & Joint Surg, Guangzhou, Guangdong, Peoples R China.
   [Ning, Tao; Zha, Zhen-Gang] Fuyang Peoples Hosp, Dept Orthopaed Surg, Fuyang, Anhui, Peoples R China.
C3 Jinan University; Jinan University
RP Zha, ZG (通讯作者)，Jinan Univ, Affiliated Hosp 1, Inst Orthoped Dis, Guangzhou, Guangdong, Peoples R China.; Zha, ZG (通讯作者)，Jinan Univ, Affiliated Hosp 1, Dept Bone & Joint Surg, Guangzhou, Guangdong, Peoples R China.; Zha, ZG (通讯作者)，Fuyang Peoples Hosp, Dept Orthopaed Surg, Fuyang, Anhui, Peoples R China.
EM zhazhengang8277@163.com
NR 0
TC 2
Z9 3
U1 0
U2 1
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD NOV-DEC
PY 2023
VL 29
IS 8
BP 810
EP 813
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EG1E0
UT WOS:001137669200135
PM 37773645
DA 2026-07-24
ER
PT J
AU Zheng, ZL
   Couture, D
   Adams, F
   Roberson, R
   Ma, R
   Argenta, L
   Morykwas, M
AF Zheng, Zhenlin
   Couture, Daniel
   Adams, Farren
   Roberson, Rebecca
   Ma, Rong
   Argenta, Louis
   Morykwas, Michael
TI Attenuated Tissue Damage With Mechanical Tissue Resuscitation in a Pig
   Model of Spinal Cord Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE diffusion tensor imaging; mechanical tissue resuscitation; negative
   pressure treatment; nerve fiber tractography; spinal cord injury
ID VACUUM-ASSISTED CLOSURE; PORCINE MODEL; ANIMAL-MODEL; DIFFUSION;
   TRACTOGRAPHY; THERAPIES; SEVERITY; PRESSURE
AB Our previous studies on the treatment of spinal cord injuries with Mechanical Tissue Resuscitation (MTR) in rats have demonstrated that it can significantly improve the locomotor recovery and Basso Beattie Bresnahan scores. MTR treatment also reduced fluid accumulations by T2-imaging and improved the mean neural fiber number and fiber length in injured sites by fiber tractography. Myelin volume was also significantly preserved by MTR treatment. For further clinical application, a large animal model is necessary to assess this treatment. This study examined the effects of application of MTR on traumatic spinal cord injury in a swine model. Traumatic spinal cord contusion injuries in swine were created by controlled pneumatic impact device. Negative pressure at -75 mm Hg was continuously applied to the injured site through open cell silicone manifold for 7 days. In vivo magnetic resonance imaging for T2 and gradient echo (GRE) analysis employed a 3T machine, while a 7T machine was employed for diffusion tensor imaging (DTI) and fiber tractography. Histological hematoxylin and eosin (H&E) and Luxol fast blue staining were examined. MTR significantly reduced the mean injured volumes over 46% by T2-imaging in the injured sites from 477.34 +/- 146.31 mm(3) in non-treated group to 255.99 +/- 70.28 mm(3) in MTR treated group (p < 0.01). It also reduced fluid accumulations by relative T2 signal density in the epicenter of the spinal cord injury from 1.62 +/- 0.27 in non-treated group to 1.22 +/- 0.10 in the MTR treated group (p < 0.05). The mean injured tissue volume measured by H&E staining was 303.71 +/- 78.21 mm(3) in the non-treated group and decreased significantly to 162.16 +/- 33.0 mm(3) in the MTR treated group (p < 0.01). The myelin fiber bundles stained by Luxol blue were preserved much more in the MTR treated group (90 +/- 29.71 mm(3)) than in the non-treated group (33.68 +/- 24.99 mm(3), p < 0.01). The fractional anisotropy (FA) values processed by DTI analysis are increased from 0.203 +/- 0.027 in the untreated group to 0.238 +/- 0.029 in MTR treatment group (p < 0.05). Fiber tractography showings the mean fiber numbers across the impacted area were increased over 112% from 327.0 +/- 99.74 in the non-treated group to 694.83 +/- 297.86 in the MTR treated group (p < 0.05). These results indicate local application of MTR for 7 days to spinal cord injury in a swine model decreased tissue injury, reduced tissue edema, and preserved more myelin fibers as well as nerve fibers in the injured spinal cord.
C1 [Zheng, Zhenlin; Adams, Farren; Roberson, Rebecca; Ma, Rong; Argenta, Louis; Morykwas, Michael] Wake Forest Univ Hlth Sci, Dept Plast & Reconstruct Surg, Winston Salem, NC USA.
   [Couture, Daniel] Wake Forest Univ Hlth Sci, Dept Neurosurg, Winston Salem, NC USA.
   [Morykwas, Michael] Wake Forest Univ Hlth Sci, Dept Plast & Reconstruct Surg, 1 Med Ctr Blvd, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest University School of Medicine; Wake
   Forest University; Wake Forest University School of Medicine; Wake
   Forest University; Wake Forest University School of Medicine
RP Morykwas, M (通讯作者)，Wake Forest Univ Hlth Sci, Dept Plast & Reconstruct Surg, 1 Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM mmorykwa@wakehealth.edu
OI Morykwas, Michael/0009-0001-5547-5172
FU Department of Plastic and Reconstructive Surgery, Wake Forest University
   Health Science
FX This study was supported by the research endowment of the Department of
   Plastic and Reconstructive Surgery, Wake Forest University Health
   Science.
CR Alizadeh M, 2018, J NEUROTRAUM, V35, P452, DOI 10.1089/neu.2017.5174
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   Choe AS, 2017, NEURORADIOLOGY, V59, P747, DOI 10.1007/s00234-017-1860-9
   Dauleac C, 2021, MAGN RESON MED, V85, P3241, DOI 10.1002/mrm.28665
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   Morykwas MJ, 2002, J TRAUMA, V53, P537, DOI 10.1097/00005373-200209000-00023
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Schomberg DT, 2017, J NEUROTRAUM, V34, P541, DOI 10.1089/neu.2016.4567
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   Tigchelaar S, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01299-x
   Vedantam A, 2023, J NEUROTRAUM, V40, P1948, DOI 10.1089/neu.2022.0410
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   Zheng ZL, 2016, NEUROSURGERY, V78, P868, DOI 10.1227/NEU.0000000000001063
   Zheng ZL, 2014, NEUROSURGERY, V75, P152, DOI 10.1227/NEU.0000000000000341
NR 28
TC 1
Z9 1
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAY 1
PY 2024
VL 41
IS 9-10
BP 1020
EP 1029
DI 10.1089/neu.2023.0172
EA NOV 2023
PG 10
WC Critical Care Medicine; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Neurosciences & Neurology
GA SN0N7
UT WOS:001138185800001
PM 37830176
DA 2026-07-24
ER
PT J
AU Werenski, JO
   Gonzalez, MR
   Fourman, MS
   Hung, YP
   Lozano-Calderón, SA
AF Werenski, Joseph O.
   Gonzalez, Marcos R.
   Fourman, Mitchell S.
   Hung, Yin P.
   Lozano-Calderon, Santiago A.
TI Does Wound VAC Temporization Offer Patient-Reported Outcomes Similar to
   Single-Stage Excision Reconstruction After Myxofibrosarcoma Resection?
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Article
DE Patient-reported outcomes; Soft tissue sarcoma; Wound VAC temporization
ID FROZEN-SECTION; VALIDATION; RECURRENCE; SURVIVAL; PROMIS
AB Background. Vacuum-assisted closure (VAC) temporization is a promising technique to achieve local control in aggressive soft tissue sarcomas. Despite its previously reported efficacy, adoption of VAC temporization remains limited, primarily due to the scarce literature on patient-reported outcomes (PROs) supporting its efficacy. This study compared the postoperative PROs after VAC temporization or single-stage (SS) excision and reconstruction for patients undergoing surgical resection for myxofibrosarcoma management.
   Methods. A retrospective analysis of myxofibrosarcoma patients who underwent surgical resections at our institution from 2016 to 2022 was performed. Postoperative PROs collected prospectively for those treated with VAC temporization or SS excision/reconstruction were compared using a visual analog scale (VAS) for pain and three Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires: Global Health Short-Form Mental (SF Mental), Global Health Short-Form Physical (SF Physical), and Physical Function Short-Form 10a (SF 10a). Absolute and differential (postoperative minus preoperative) scores at the 1-month, 3-month, 6-month, 1-year, and 2-year time points were compared.
   Results. The analysis included 79 patients (47 treated with VAC temporization and 32 treated with SS excision/reconstruction). All outcomes were similar between the groups except for physical function 1 year after surgery, in which the differential PROMIS SF 10a scores were higher in the SS group (p = 0.001). All the remaining absolute and differential PROMIS and VAS pain scores were similar between the groups at all time points. Postoperative complications did not differ between the groups.
   Conclusion. The PROs for physical and mental health, physical function, and pain were similar between the myxofibrosarcoma patients who had VAC temporization and those who had SS excision/reconstruction after surgical resection.
C1 [Werenski, Joseph O.; Gonzalez, Marcos R.; Lozano-Calderon, Santiago A.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Orthopaed Surg, Orthopaed Oncol Serv, Boston, MA 02115 USA.
   [Fourman, Mitchell S.] Montefiore Einstein, Dept Orthopaed Surg, New York, NY USA.
   [Hung, Yin P.] Harvard Med Sch, Massachusetts Gen Hosp, Div Bone & Soft Tissue Pathol, Dept Pathol, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   Medical School
RP Lozano-Calderón, SA (通讯作者)，Harvard Med Sch, Massachusetts Gen Hosp, Dept Orthopaed Surg, Orthopaed Oncol Serv, Boston, MA 02115 USA.
RI Hung, Yin Pun/AAV-4868-2021; Gonzalez, Marcos/IAP-3703-2023; Fourman,
   Mitchell/GXF-4477-2022
OI Hung, Yin Pun/0000-0002-8568-1591; Werenski, Joseph/0009-0003-9177-6874;
   
CR Agarwal A, 2022, MED J AUSTRALIA, V216, P9, DOI 10.5694/mja2.51355
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NR 27
TC 9
Z9 9
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1068-9265
EI 1534-4681
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD APR
PY 2024
VL 31
IS 4
BP 2757
EP 2765
DI 10.1245/s10434-023-14839-9
EA JAN 2024
PG 9
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA XG7R1
UT WOS:001139621800005
PM 38197999
DA 2026-07-24
ER
PT J
AU Imaoka, S
   Samura, T
   Yoshioka, D
   Kawamura, M
   Kawamura, T
   Toda, K
   Miyagawa, S
AF Imaoka, Shusuke
   Samura, Takaaki
   Yoshioka, Daisuke
   Kawamura, Masashi
   Kawamura, Takuji
   Toda, Koichi
   Miyagawa, Shigeru
TI Clinical Outcomes of Left Ventricular Assist Device Pump Infection
SO ASAIO JOURNAL
LA English
DT Article
DE left ventricular assist device; pump infection
ID HEART-TRANSPLANT; PARACORPOREAL; STRATEGIES; MANAGEMENT
AB Few studies have focused on the clinical outcomes and risk factors of left ventricular assist device (LVAD) pump infection, and no standard treatment for LVAD pump infection has been established. Therefore, we used a therapeutic flowchart to manage LVAD pump infections. We retrospectively evaluated 220 patients who underwent continuous-flow LVAD implantation between January 2005 and March 2021 at Osaka University, Japan. First, we performed wound debridement, negative-pressure wound therapy, antibiotic treatment, and omental flap transposition. Subsequently, we administered conservative treatment, scheduled implantable LVAD exchange, or emergent removal of the implantable LVAD and exchange for extracorporeal LVAD or percutaneous LVAD (IMPELLA). Pump infections occurred in 32 patients. The survival rates of patients with pump infections during LVAD support were 93%, 74%, and 61% at 180 days, 1 year, and 2 years after LVAD pump infection, respectively. Fifteen patients underwent successful heart transplantation. Bridge-to-bridge surgery, preoperative use of venoarterial extracorporeal membrane oxygenation or percutaneous LVAD, high lactate dehydrogenase levels, and driveline infection were significantly associated with pump infection. Our study reveals that poor preoperative condition and driveline infection were significant risk factors for LVAD pump infection.
C1 [Imaoka, Shusuke; Samura, Takaaki; Yoshioka, Daisuke; Kawamura, Masashi; Kawamura, Takuji; Miyagawa, Shigeru] Osaka Univ, Grad Sch Med, Dept Cardiovasc Surg, Osaka, Japan.
   [Toda, Koichi] Dokkyo Med Univ, Saitama Med Ctr, Dept Thorac & Cardiovasc Surg, Saitama, Japan.
   [Yoshioka, Daisuke] Osaka Univ, Grad Sch Med, Dept Cardiovasc Surg, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
C3 University of Osaka; Dokkyo Medical University; University of Osaka
RP Yoshioka, D (通讯作者)，Osaka Univ, Grad Sch Med, Dept Cardiovasc Surg, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM djason55@gmail.com
RI Samura, Takaaki/OVY-9880-2025
OI Samura, Takaaki/0000-0002-3514-4413
CR Bauer TM, 2019, ARTIF ORGANS, V43, P448, DOI 10.1111/aor.13378
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NR 17
TC 5
Z9 6
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1058-2916
EI 1538-943X
J9 ASAIO J
JI Asaio J.
PD DEC
PY 2023
VL 69
IS 12
BP 1056
EP 1064
DI 10.1097/MAT.0000000000002031
PG 9
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA EY4W1
UT WOS:001142492900006
PM 37549664
DA 2026-07-24
ER
PT J
AU Baucom, MR
   Wallen, TE
   Youngs, J
   Singer, KE
   Delman, AM
   Schuster, RM
   Blakeman, TC
   Strilka, R
   Pritts, TA
   Goodman, MD
AF Baucom, Matthew R.
   Wallen, Taylor E.
   Youngs, Jaclyn
   Singer, Kathleen E.
   Delman, Aaron M.
   Schuster, Rebecca M.
   Blakeman, Thomas C.
   Strilka, Richard
   Pritts, Timothy A.
   Goodman, Michael D.
TI Effectiveness of Negative Pressure Wound Therapy During Aeromedical
   Evacuation Following Soft Tissue Injury and Infection
SO MILITARY MEDICINE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BACTERIAL-COLONIZATION; IRRIGATION; CASUALTIES;
   BIOBURDEN; SALINE; LOAD; CARE
AB Introduction Negative pressure wound therapy (NPWT) is utilized early after soft tissue injury to promote tissue granulation and wound contraction. Early post-injury transfers via aeromedical evacuation (AE) to definitive care centers may actually induce wound bacterial proliferation. However, the effectiveness of NPWT or instillation NPWT in limiting bacterial proliferation during post-injury AE has not been studied. We hypothesized that instillation NPWT during simulated AE would decrease bacterial colonization within simple and complex soft tissue wounds. Methods The porcine models were anesthetized before any experiments. For the simple tissue wound model, two 4-cm dorsal wounds were created in 34.90.6kg pigs and were inoculated with Acinetobacter baumannii (AB) or Staphylococcus aureus 24hours before a 4-hour simulated AE or ground control. During AE, animals were randomized to one of the five groups: wet-to-dry (WTD) dressing, NPWT, instillation NPWT with normal saline (NS-NPWT), instillation NPWT with Normosol-R (R) (NM-NPWT), and RX-4-NPWT with the RX-4 system. For the complex musculoskeletal wound, hind-limb wounds in the skin, subcutaneous tissue, peroneus tertius muscle, and tibia were created and inoculated with AB 24hours before simulated AE with WTD or RX-4-NPWT dressings. Blood samples were collected at baseline, pre-flight, and 72hours post-flight for inflammatory cytokines interleukin (IL)-1 beta, IL-6, IL-8 and tumor necrosis factor alpha. Wound biopsies were obtained at 24hours and 72hours post-flight, and the bacteria were quantified. Vital signs were measured continuously during simulated AE and at each wound reassessment. Results No significant differences in hemodynamics or serum cytokines were noted between ground or simulated flight groups or over time in either wound model. Simulated AE alone did not affect bacterial proliferation compared to ground controls. The simple tissue wound arm demonstrated a significant decrease in Staphylococcus aureus and AB colony-forming units at 72hours after simulated AE using RX-4-NPWT. NS-NPWT during AE more effectively prevented bacterial proliferation than the WTD dressing. There was no difference in colony-forming units among the various treatment groups at the ground level. Conclusion The hypoxic, hypobaric environment of AE did not independently affect the bacterial growth after simple tissue wound or complex musculoskeletal wound. RX-4-NPWT provided the most effective bacterial reduction following simulated AE, followed by NS-NPWT. Future research will be necessary to determine ideal instillation fluids, negative pressure settings, and dressing change frequency before and during AE.
C1 [Baucom, Matthew R.; Wallen, Taylor E.; Youngs, Jaclyn; Singer, Kathleen E.; Delman, Aaron M.; Schuster, Rebecca M.; Blakeman, Thomas C.; Pritts, Timothy A.; Goodman, Michael D.] Univ Cincinnati, Dept Surg, Cincinnati, OH 45267 USA.
   [Strilka, Richard] Univ Cincinnati, US Air Force Sch Aerosp Med, Route Care Training Dept, Cincinnati, OH 45267 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; U.S. Air Force School of Aerospace
   Medicine
RP Baucom, MR (通讯作者)，Univ Cincinnati, Dept Surg, Cincinnati, OH 45267 USA.
RI ; Wallen, Taylor/QMS-0406-2026
OI Goodman, Michael/0000-0001-7218-4855; Strilka,
   Richard/0000-0003-2707-7991; 
FU DoD [USAF FA8650-20-2-6G36]; NIH-Ruth Kirschstein T32 training grant
   [5T32GM008478-29]; National Institute of General Medical Sciences
   [T32GM008478] Funding Source: NIH RePORTER
FX This study was supported by the DoD grant (No. USAF FA8650-20-2-6G36)
   and NIH-Ruth Kirschstein T32 training grant (No. 5T32GM008478-29).
CR Aerosp Med Assoc, 2008, AVIAT SPACE ENVIR MD, V79, P433, DOI 10.3357/ASEM.2272.2008
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NR 36
TC 3
Z9 5
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV 8
PY 2023
VL 188
SU _6
BP 295
EP 303
DI 10.1093/milmed/usad113
EA NOV 2023
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EZ5M9
UT WOS:001142773700039
PM 37948243
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Bota, O
   Heinzinger, LM
   Herzog, B
   Disch, AC
   Amlang, M
   Flössel, P
   Dragu, A
   Taqatqeh, F
AF Bota, Olimpiu
   Heinzinger, Leona M.
   Herzog, Bianka
   Disch, Alexander C.
   Amlang, Michael
   Floessel, Philipp
   Dragu, Adrian
   Taqatqeh, Feras
TI Evaluation of the ankle function after Achilles tendon resection: a
   retrospective clinical study
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE Achilles tendon infection; Achilles tendon reconstruction; Achilles
   tendon repair; Foot and ankle surgery; Reconstructive surgery; Negative
   pressure wound therapy
ID SOFT-TISSUE DEFECTS; RECONSTRUCTION; FLAP; COMPLICATIONS; MANAGEMENT;
   COVERAGE
AB IntroductionThe Achilles tendon is the strongest tendon in the human body and has the function of plantar ankle flexion. When the tendon is exposed, the peritendineum has been breached and the thick avascular tendon colonized with bacteria, a complete resection of the tendon may be indicated to achieve infection control and facilitate wound closure. The Achilles tendon reconstruction is not mandatory, as the plantar flexion of the ankle joint is assumed by the remaining flexor hallucis longus, flexor digitorum longus and tibialis posterior muscles. Our study aimed to evaluate the impact of Achilles tendon resection without reconstruction on leg function and quality of life.Material and methodsWe retrospectively evaluated all patients who were treated with an Achilles tendon resection between January 2017 and June 2022 in our quaternary institution. After evaluating the data, the patients who survived and were not amputated were contacted for re-evaluation, which included isokinetic strength measurement of both ankle joints, evaluation of the ankle range of motion and collection of several functional scores.ResultsThirty patients were included in the retrospective study, with a mean age of 70.3 years, including 11 women and 19 men. The most frequent cause of the infection was leg ulcer (43.3%), followed by open tendon suture (23.3%). No tendon reconstruction was performed. Fifteen patients could be gained for reevaluation. The average difference in ankle flexion torque on the injured side compared to the healthy side at 30 degrees/second was 57.49% (p = 0.003) and at 120 degrees/second was 53.13% (p = 0.050) while the difference in power was 45.77% (p = 0.025) at 30 degrees/second and 38.08% (p = 0.423) at 120 degrees/second. The follow-up time was between 4 and 49 months and a positive correlation could be determined between the time elapsed from surgery and the ankle joint strength. There was a significant loss of range of motion on the operated side compared to the healthy side: 37.30% for plantar flexion, 24.56% for dorsal extension, 27.79% for pronation and 24.99% for supination. The average Lepillhati Score was 68.33, while the average American Orthopedic Foot and Ankle Score was 74.53.ConclusionThe complete Achilles tendon resection leaves the patient with satisfactory leg function and an almost normal gait. Especially in elderly, multimorbid patients, straightforward tendon resection and wound closure provide fast infection control with acceptable long-term results. Further prospective studies should compare the ankle function and gait in patients with and without Achilles tendon reconstruction after complete resection.
C1 [Bota, Olimpiu; Heinzinger, Leona M.; Herzog, Bianka; Disch, Alexander C.; Amlang, Michael; Dragu, Adrian; Taqatqeh, Feras] Tech Univ Dresden, Univ Ctr Orthoped Trauma & Plast Surg, Fac Med Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany.
   [Bota, Olimpiu] Iuliu Hatieganu Univ Med & Pharm, Emergency Cty Hosp Cluj Napoca, Dept Plast Surg, Surg Clin 1, Cluj Napoca, Romania.
   [Disch, Alexander C.; Floessel, Philipp] Tech Univ Dresden, Univ Ctr Orthoped Trauma & Plast Surg, Fac Med Carl Gustav Carus, Sect Sports Med & Rehabil, Dresden, Germany.
C3 Technische Universitat Dresden; Iuliu Hatieganu University of Medicine &
   Pharmacy; Technische Universitat Dresden
RP Bota, O (通讯作者)，Tech Univ Dresden, Univ Ctr Orthoped Trauma & Plast Surg, Fac Med Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany.; Bota, O (通讯作者)，Iuliu Hatieganu Univ Med & Pharm, Emergency Cty Hosp Cluj Napoca, Dept Plast Surg, Surg Clin 1, Cluj Napoca, Romania.
EM drolimpiubota@gmail.com
RI Bota, Olimpiu/AAN-4292-2021; Dragu, Adrian/AAH-3506-2019
OI Bota, Olimpiu/0000-0002-5836-1269; Dragu, Adrian/0000-0003-4633-2695
FU Technische Universitt Dresden (1019)
FX No Statement Available
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NR 31
TC 0
Z9 1
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD MAR
PY 2024
VL 144
IS 3
BP 1243
EP 1257
DI 10.1007/s00402-023-05177-2
EA JAN 2024
PG 15
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA JG6H3
UT WOS:001144067500001
PM 38231207
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Sexton, FC
   Soh, V
   Yahya, MS
   Healy, DA
AF Sexton, Fiona C.
   Soh, Vernie
   Yahya, Muhammad S.
   Healy, Donagh A.
TI Effectiveness of negative-pressure wound therapy to standard therapy in
   the prevention of complications after vascular surgery
SO MINERVA SURGERY
LA English
DT Review
DE Negative-pressure wound therapy; Vascular surgical procedures;
   Peripheral vascular diseases
ID VACUUM-ASSISTED CLOSURE; SURGICAL-SITE INFECTIONS; MECHANISMS;
   EXPRESSION; TRIAL; RISK; DEVICE
AB Wound complications are common after vascular surgery and many may be preventable. Negative pressure wound thera-py (NPWT) dressings may be able to reduce wound complications relating to closed incisions following vascular surgery and several devices are currently available along with a large body of literature. This review article will describe the use of NPWT dressings in vascular surgery. We will summarize the currently available systems, the likely mechanism of action of NWPT, the published studies to date and we will give our recommendations regarding the priorities for future research on this topic.
C1 [Sexton, Fiona C.] Beaumont Hosp, Dept Dermatol, Dublin, Ireland.
   [Soh, Vernie; Yahya, Muhammad S.; Healy, Donagh A.] Belfast Hlth & Social Care Trust, Dept Vasc Surg, Belfast, North Ireland.
   [Healy, Donagh A.] Royal Victoria Hosp, Dept Vasc Surg, 274 Grosvenor Rd, Belfast BT12 6BA, North Ireland.
C3 Beaumont Hospital Dublin
RP Healy, DA (通讯作者)，Royal Victoria Hosp, Dept Vasc Surg, 274 Grosvenor Rd, Belfast BT12 6BA, North Ireland.
EM donagh.healy@belfasttrust.hscni.net
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   Scherer SS, 2009, PLAST RECONSTR SURG, V124, P1458, DOI 10.1097/PRS.0b013e3181bbc829
   Sexton F, 2020, INT J SURG, V76, P94, DOI 10.1016/j.ijsu.2020.02.037
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   The VAC, 2021, VAC VERAFLO THERAPY
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   Zaver V., 2023, NEGATIVE PRESSURE WO
NR 65
TC 1
Z9 1
U1 0
U2 0
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-5691
EI 2724-5438
J9 MINERVA SURG
JI Minerva Surg.
PD FEB
PY 2024
VL 79
IS 1
BP 48
EP 58
DI 10.23736/S2724-5691.23.10096-7
EA NOV 2023
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QO5R7
UT WOS:001145691900001
PM 37930087
DA 2026-07-24
ER
PT J
AU Schaum, KD
AF Schaum, Kathleen D.
TI Disposable Negative-Pressure Wound Therapy Reimbursement Simplified for
   Home Health Agencies
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
C1 [Schaum, Kathleen D.] Kathleen D Schaum & Associates Inc, Lake Worth, FL USA.
   [Schaum, Kathleen D.] 6491 Rock Creek Dr, Lake Worth, FL 33467 USA.
C3 Kathleen D. Schaum & Associates
RP Schaum, KD (通讯作者)，6491 Rock Creek Dr, Lake Worth, FL 33467 USA.
EM kathleendschaum@bellsouth.net
CR Centers for Medicare & Medicaid Services, 2024, HOME HLTH CONSOLIDAT
   Department of Health and Human Services Centers for Medicare & Medicaid Services, 2024, HOME HLTH PROSPECTIV
NR 2
TC 0
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD FEB
PY 2024
VL 37
IS 2
BP 65
EP 66
DI 10.1097/ASW.0000000000000100
PG 2
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA FQ1X8
UT WOS:001147234700005
PM 38241448
DA 2026-07-24
ER
PT J
AU Zhao, ZW
   Ma, DJ
   Xu, Y
   Guo, C
   Li, SQ
   Wang, J
   Wang, M
   Qin, YZ
   Liu, HS
AF Zhao, Zhewei
   Ma, Dongjie
   Xu, Yuan
   Guo, Chao
   Li, Shanqing
   Wang, Jian
   Wang, Mu
   Qin, Yingzhi
   Liu, Hongsheng
TI Surgical therapy and outcome of descending necrotizing mediastinitis in
   Chinese: a single-center series
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE descending necrotizing mediastinitis; video-assisted thoracic surgery;
   transcervical drainage; transthoracic drainage; surgical treatment
ID MANAGEMENT; STATEMENT
AB BackgroundDescending Necrotizing Mediastinitis (DNM) is an acute and often fatal infection that affects the neck and mediastinum. DNM treatment consists of broad-spectrum antibiotics, early diagnosis, and surgical debridement with multidisciplinary cooperation. However, owing to the rarity and complexity of this disease, the mortality rate is high. This retrospective study analyzed a single-center experience of managing DNM in Chinese patients over the last 10 years.MethodsA single-center, retrospective, observational, and descriptive study was conducted on 31 patients with DNM at Peking Union Medical College Hospital from 2012 to 2022. Case report forms were used to collect data which were then analyzed with a focus on surgical management and outcomes.ResultsThis study examined the outcomes of 31 patients diagnosed with DNM at our hospital. The most common comorbidities on admission were hypertension (48%) and diabetes mellitus (42%). The degree of diffusion of DNM according to Endo's classification was classified as follows: type I in 7 patients (22.6%), type IIA in 5 (16.1%), and type IIB in 19 patients (61.3%). Among these patients, 13 (41.9%) were found to have a single microbial infection, while 16 (51.6%) were found to have polymicrobial infections. In all cases, neck drainage was performed via cervicotomy, with multiple drains (64.5%) and vacuum sealing drainage (VSD) (35.5%). Mediastinal drainage was performed via a cervical mediastinotomy (51.6%), video-assisted thoracic surgery (VATS) (41.9%), or thoracotomy (6.5%). The 30-day mortality rate was 25.8% and 24.0 days of the average length of hospital stay.ConclusionEarly accurate diagnosis and timely intervention have been shown to be correlated with a positive prognosis. Cervicothoracic CT (computed tomography) is essential for the diagnosis, staging, and evaluation of the optimal surgical treatment. Cervicotomy and video-assisted thoracoscopic surgery with percutaneous drainage is effective, even in advanced cases. Additionally, the application of VSD in cervical incision did not improve prognosis but may shorten the length of ICU (intensive care unit) and hospital stays.
C1 [Zhao, Zhewei; Ma, Dongjie; Xu, Yuan; Guo, Chao; Li, Shanqing; Qin, Yingzhi; Liu, Hongsheng] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Thorac Surg, Beijing, Peoples R China.
   [Wang, Jian] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept ENT, Beijing, Peoples R China.
   [Wang, Mu] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Stomatol, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Qin, YZ; Liu, HS (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Thorac Surg, Beijing, Peoples R China.
EM qinyzh@pumch.cn; hongshengliu16@163.com
RI Guo, Chao/PTE-6398-2026
OI Wang, Mu/0000-0003-1777-2309
FU National Natural Science Foundation of China [82102745]; National High
   Level Hospital Clinical Research Funding [2022-PUMCH-A-187,
   2022-PUMCH-B-012]; CAMS Innovation Fund for Medical Sciences (CIFMS)
   [2022 I2M CT B 002]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the National Natural Science Foundation of China (No. 82102745), the
   National High Level Hospital Clinical Research Funding (Nos.
   2022-PUMCH-A-187 and 2022-PUMCH-B-012), and the CAMS Innovation Fund for
   Medical Sciences (CIFMS) (No. 2022 I2M C&T B 002).
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NR 32
TC 9
Z9 12
U1 2
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JAN 11
PY 2024
VL 10
AR 1337852
DI 10.3389/fmed.2023.1337852
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FU1S5
UT WOS:001148283600001
PM 38274461
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rabel, T
   Bonnot, PE
   Hadeedi, O
   Kepenekian, V
   Bernard, L
   Friggeri, A
   Glehen, O
   Passot, G
AF Rabel, Thomas
   Bonnot, Pierre-Emmanuel
   Hadeedi, Omar
   Kepenekian, Vahan
   Bernard, Lorraine
   Friggeri, Arnaud
   Glehen, Olivier
   Passot, Guillaume
TI Negative-Pressure Wound Therapy for Open Abdomen in Surgical
   Reintervention after Curative Surgery of Peritoneal Malignancy Increases
   the Risk of Recurrence
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE abdomen; cancer; cytoreduction; emergency surgery; laparostomy;
   malignancy; negative-pressure wound therapy; peritoneal carcinomatosis;
   recurrence; surgery
ID VACUUM-ASSISTED CLOSURE
AB OBJECTIVE: Negative-pressure wound therapy for open abdomen (NPWTOA) helps reduce the risk of abdominal compartment syndrome. However, the risk of recurrence of cancer is unclear when NPWTOA is applied after oncologic resection. The aim of this study was to evaluate the effects of NPWTOA used for major complications on patients treated with cytoreductive surgery for peritoneal malignancy (PM). METHODS: All patients who underwent an NPWTOA after potentially curative surgery of PM in a single institution were included. These patients were pair matched 1:3 on the Peritoneal Cancer Index, completeness of cytoreduction using a scoring index, and PM origin with patients who underwent surgical reintervention without NPWTOA after curative surgery of PM. Survival among the two groups was compared using the Kaplan-Meier method. RESULTS: Between 2011 and 2017, among 719 curative surgeries for PM, 13 patients underwent an NPWTOA after surgical reintervention. Researchers paired 9 of these patients to 27 others without NPWTOA after surgical reintervention. Median overall survival was 4.8 and 35 months (P = .391), and median disease-free survival was 4.0 and 13.9 months (P = .022) for the NPWTOA and non-NPWTOA groups, respectively. CONCLUSIONS: The use of the NPWTOA during surgical reintervention after curative surgery for PM may increase the risk of early recurrence.
C1 [Rabel, Thomas; Bonnot, Pierre-Emmanuel; Hadeedi, Omar; Kepenekian, Vahan; Bernard, Lorraine] Hosp Civils Lyon, Hosp Lyon Sud, Dept Visceral & Oncol Surg, Lyon, France.
   [Friggeri, Arnaud] Hosp Civils Lyon, Dept Biostat, Lyon, France.
   [Glehen, Olivier; Passot, Guillaume] Hop Lyon Sud, Dept Anesthesiol & Intens Care, Lyon, France.
   [Glehen, Olivier; Passot, Guillaume] Hosp Lyon Sud, Dept Visceral & Oncol Surg, Lyon, France.
C3 CHU Lyon; CHU Lyon; CHU Lyon; CHU Lyon
RP Rabel, T (通讯作者)，Hosp Civils Lyon, Hosp Lyon Sud, Dept Visceral & Oncol Surg, Lyon, France.
RI Passot, Guillaume/K-6271-2012; Friggeri, Arnaud/AAE-7644-2020;
   Kepenekian, Vahan/AFF-8361-2022
CR Alyami M, 2018, INT J HYPERTHER, V34, P532, DOI 10.1080/02656736.2017.1367846
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NR 25
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2023
VL 36
IS 11
BP 6
EP 6
DI 10.1097/ASW.0000000000000018
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA GD2G8
UT WOS:001150656300006
PM 37861668
DA 2026-07-24
ER
PT J
AU Ciuntu, BM
   Tanevski, A
   Buescu, DO
   Lutenco, V
   Mihailov, R
   Ciuntu, MS
   Zuzu, MM
   Vintila, D
   Zabara, M
   Trofin, A
   Cadar, R
   Nastase, A
   Ursulescu, CL
   Lupascu, CD
AF Ciuntu, Bogdan Mihnea
   Tanevski, Adelina
   Buescu, David Ovidiu
   Lutenco, Valerii
   Mihailov, Raul
   Ciuntu, Madalina Stefana
   Zuzu, Mihai Marius
   Vintila, Dan
   Zabara, Mihai
   Trofin, Ana
   Cadar, Ramona
   Nastase, Alexandru
   Ursulescu, Corina Lupascu
   Lupascu, Cristian Dumitru
TI Endoscopic Vacuum-Assisted Closure (E-VAC) in Septic Shock from
   Perforated Duodenal Ulcers with Abscess Formations
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE E-VAC; negative pressure therapy; perforated duodenal ulcer; abscess
ID THERAPY; LEAK
AB This case report underscores the importance of utilizing E-VAC (endoscopic vacuum-assisted closure) in the treatment of a perforated duodenal ulcer complicated by the formation of a subphrenic abscess and septic shock. It showcases how E-VAC can effectively mitigate the risk of further complications, such as leakage, bleeding, or rupture, which are more commonly associated with traditional methods like stents, clips, or sutures. As a result, there is a significant reduction in mortality rates. A perforated duodenal ulcer accompanied by abscess formation represents a critical medical condition that demands prompt surgical intervention. The choice of the method for abscess drainage and perforation closure plays a pivotal role in determining the patient's chances of survival. Notably, in patients with a high ASA (American Association of Anesthesiologists) score of IV-V, the mortality rate following conventional surgical intervention is considerably elevated. The management of perforated duodenal ulcers has evolved from open abdominal surgical procedures, which were associated with high mortality rates and risk of suture repair leakage, to minimally invasive techniques like laparoscopy and ingestible robots. Previously, complications arising from peptic ulcers, such as perforations, leaks, and fistulas, were primarily addressed through surgical and conservative treatments. However, over the past two decades, the medical community has shifted towards employing endoscopic closure techniques, including stents, clips, and E-VAC. E-VAC, in particular, has shown promising outcomes by promoting rapid and consistent healing. This case report presents the clinical scenario of a patient diagnosed with septic shock due to a perforated duodenal ulcer with abscess formation. Following an exploratory laparotomy that confirmed the presence of a subphrenic abscess, three drainage tubes were utilized to evacuate it. Subsequently, E-VAC therapy was initiated, with the kit being replaced three times during the recovery period. The patient exhibited favorable progress, including weight gain, and was ultimately discharged as fully recovered. In the treatment of patients with duodenal perforated ulcers and associated abscess formation, the successful and comprehensive drainage of the abscess, coupled with the closure of the perforation, emerges as a pivotal factor influencing the patient's healing process. The positive outcomes observed in these patients underscore the efficacy of employing a negative pressure E-VAC kit, resulting in thorough drainage, rapid patient recovery, and low mortality rates.
C1 [Ciuntu, Bogdan Mihnea; Tanevski, Adelina; Buescu, David Ovidiu; Zuzu, Mihai Marius; Vintila, Dan; Zabara, Mihai; Trofin, Ana; Cadar, Ramona; Nastase, Alexandru; Lupascu, Cristian Dumitru] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Gen Surg, 16 Univ St, Iasi 700115, Romania.
   [Ciuntu, Bogdan Mihnea; Tanevski, Adelina; Buescu, David Ovidiu; Zuzu, Mihai Marius; Vintila, Dan; Zabara, Mihai; Trofin, Ana; Cadar, Ramona; Nastase, Alexandru; Lupascu, Cristian Dumitru] St Spiridon Cty Emergency Clin Hosp, Gen Surg Clin, 1 Independence Blvd, Iasi 700111, Romania.
   [Lutenco, Valerii; Mihailov, Raul] Dunarea de Jos Univ Med & Pharm, Fac Med, Dept Gen Surg, Galati 800010, Romania.
   [Lutenco, Valerii; Mihailov, Raul] St Apostol Andrei Cty Emergency Clin Hosp, Gen Surg Clin, Str Brailei 177, Galati 800578, Romania.
   [Ciuntu, Madalina Stefana] Grigore T Popa Univ Med & Pharm, Fac Med, 16 Univ St, Iasi 700115, Romania.
   [Ursulescu, Corina Lupascu] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Radiol, 16 Univ St, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Dunarea De Jos
   University Galati; Grigore T Popa University of Medicine & Pharmacy;
   Grigore T Popa University of Medicine & Pharmacy
RP Ciuntu, BM; Tanevski, A (通讯作者)，Grigore T Popa Univ Med & Pharm, Fac Med, Dept Gen Surg, 16 Univ St, Iasi 700115, Romania.; Ciuntu, BM; Tanevski, A (通讯作者)，St Spiridon Cty Emergency Clin Hosp, Gen Surg Clin, 1 Independence Blvd, Iasi 700111, Romania.
EM bogdan-mihnea.ciuntu@ummfiasi.ro; papancea.adelina@umfiasi.ro;
   buescu_david-ovidiu@d.umfiasi.ro; vl187@student.ugal.ro;
   raul.mihailov@ugal.ro; mg-eng-24128@students.umfiasi.ro;
   zuzumihai@gmail.com; danersilia@yahoo.com; mihai.zabara@umfiasi.ro;
   ana-maria.trofin@umfiasi.ro; ramona-petronela.cadar@umfiasi.ro;
   nastase_grigorie-alexandru@d.umfiasi.ro; corina.ursulescu@umfiasi.ro;
   cristian.lupascu@umfiasi.ro
RI Lutenco, Valerii/KFQ-3946-2024; Nastase, Alexandru/NFS-1873-2025;
   Tanevski, Adelina/LUZ-8095-2024; Trofin, Ana/A-2361-2015; Ciuntu,
   Bogdan/MTF-9477-2025; Raul, Mihailov/IQU-7822-2023
OI Lutenco, Valerii/0009-0001-6620-7851; Lupascu-Ursulescu,
   Corina/0000-0002-7539-9453; Raul, Mihailov/0000-0001-7081-9490
CR Abbitt D, 2021, J SURG CASE REP, V2021, DOI 10.1093/jscr/rjab479
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NR 32
TC 3
Z9 3
U1 4
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN
PY 2024
VL 13
IS 2
AR 470
DI 10.3390/jcm13020470
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GF9O5
UT WOS:001151370400001
PM 38256604
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mascarenhas, DC
   Nasra, M
   Tawfik, A
   Ghazi, J
   Ishmael, T
   Therrien, PJ
   Bowe, JA
   Tuason, D
AF Mascarenhas, Daniel C.
   Nasra, Matthew
   Tawfik, Amr
   Ghazi, John
   Ishmael, Terrence
   Therrien, Phillip J.
   Bowe, John A.
   Tuason, Dominick
TI Incisional Negative Pressure Wound Therapy Does Not Affect Deep Surgical
   Site Infection Rates in Neuromuscular Scoliosis Surgery
SO ORTHOPEDICS
LA English
DT Article
ID SPINAL-FUSION; RISK-FACTORS; COMPLICATIONS; CHILDREN
AB Surgical site infection (SSI) is a devastating complication in patients with neuromuscular scoliosis (NMS) undergoing posterior spinal instrumented fusion (PSIF) for progressive scoliosis. Incisional negative pressure wound therapy (INPWT) has been used in other surgical fields to reduce SSI. Our purpose was to examine the prophylactic use of INPWT after NMS surgery to decrease SSI. At a single institution, 71 consecutive patients with NMS underwent PSIF from 2015 to 2019. Starting in 2017, all patients with NMS received INPWT postoperatively until discharge. Rates of deep SSI were compared between the two cohorts of patients. Additionally, patient demographic and operative factors such as American Society of Anesthesiologists score, number of levels instrumented, need for an anterior spinal release, need for spinal fusion to pelvis, blood loss, operative time, fluoroscopy time, length of stay, and transfusion requirement were analyzed for potential influence on deep SSI. There was no significant difference in deep SSI rates between patients who received INPWT (2 of 41) and those treated with a standard postoperative dressing (2 of 30; P=1.0). Although INPWT theoretically can stabilize the wound environment and prevent deep SSI, our findings do not support this. More research is needed to evaluate the efficacy of INPWT after PSIF for NMS.
C1 [Mascarenhas, Daniel C.; Nasra, Matthew; Tawfik, Amr; Ghazi, John; Ishmael, Terrence; Therrien, Phillip J.; Bowe, John A.] Rutgers State Univ, Dept Orthopaed, Rutgers Robert Wood Johnson Med Sch, 52 French St,MEB 422, New Brunswick, NJ 08901 USA.
   [Tuason, Dominick] Yale Univ, Yale Sch Med, Dept Orthopaed, New Haven, CT USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Yale University
RP Mascarenhas, DC (通讯作者)，Rutgers State Univ, Dept Orthopaed, Rutgers Robert Wood Johnson Med Sch, 52 French St,MEB 422, New Brunswick, NJ 08901 USA.
EM daniel-mascarenhasorthopaedic@gmail.com
CR Aleissa S, 2011, CAN J SURG, V54, P263, DOI 10.1503/cjs.008210
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NR 21
TC 4
Z9 6
U1 0
U2 1
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD NOV-DEC
PY 2023
VL 46
IS 6
BP 373
EP 378
DI 10.3928/01477447-20230329-03
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA GK1V8
UT WOS:001152481600018
PM 37018618
DA 2026-07-24
ER
PT J
AU Nuhiji, E
AF Nuhiji, Edin
TI Trends and Innovation in Negative Pressure Wound Therapy: A Review of
   Burn Wound Management
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE burns; negative pressure wound therapy; negative pressure with
   instillation and dwell time; wound bed preparation; review
ID ASSISTED CLOSURE DEVICE; INITIAL-EXPERIENCE; CARE
AB Significance: Burns result in irretrievable cell damage, which can occur upon exposure to hot surfaces, liquids, gases, ultraviolet or ionizing radiation, and through friction. Standard of care in burn management involves protecting the patient, limiting burn progression, and achieving wound closure. Negative pressure wound therapy (NPWT) and NPWT with instillation and dwell time (NPWTi-d) are two wound management options that have been shown to improve outcomes for burn patients in recent years. This work provides a general review of NPWT and NPWTi-d use in burn wound management. A literature search was performed using PubMed and Embase for peer-reviewed publications and conference abstracts written in English and reporting on burn management using NPWT and/or NPWTi-d from a single manufacturer between 2000 and 2021. All burn types were included. Recent Advances: Thirteen studies and 308 patients were available for assessment. Use of NPWT was reported in a majority of studies (n = 11). When conventional NPWT was applied, graft take of >90% was observed and consistent final wound closure was achieved. Two studies described NPWTi-d use for burn wound management. NPWTi-d use promoted granulation tissue development in burn wounds. Critical Issues: Limited high-level prospective evidence exists for use of NPWT and NPWTi-d in burn wound management. Future Directions: Available literature on the use of NPWT and/or NPWTi-d in burn care has reported improved outcomes in wound bed preparation, which can ultimately lead to final wound closure. The use of these modalities should be considered in management of burn care patients.
C1 [Nuhiji, Edin] 3M Hlth Care, Global Med Sci, N Ryde, NSW, Australia.
   [Nuhiji, Edin] 3M Hlth Care, Global Med Sci, Bldg A,1 Rivett Rd, N Ryde, NSW 2113, Australia.
C3 3M; 3M
RP Nuhiji, E (通讯作者)，3M Hlth Care, Global Med Sci, Bldg A,1 Rivett Rd, N Ryde, NSW 2113, Australia.
EM enuhiji@mmm.com
OI Nuhiji, Edin/0009-0001-2376-376X
CR Adamkova M, 2005, Acta Chir Plast, V47, P24
   Bi HD, 2018, J RECONSTR MICROSURG, V34, P200, DOI 10.1055/s-0037-1608621
   Bloemen MCT, 2012, WOUND REPAIR REGEN, V20, P797, DOI 10.1111/j.1524-475X.2012.00845.x
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   Carney BC, 2021, J BURN CARE RES, V42, P633, DOI 10.1093/jbcr/irab075
   Chong Si Jack, 2010, Burns, V36, pe127, DOI 10.1016/j.burns.2010.05.007
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NR 31
TC 11
Z9 13
U1 3
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD AUG 1
PY 2024
VL 13
IS 8
BP 391
EP 399
DI 10.1089/wound.2023.0114
EA DEC 2023
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA A7O0L
UT WOS:001152579200001
PM 37933900
OA hybrid
DA 2026-07-24
ER
PT J
AU Dai, HY
   Wang, YC
   Xu, JG
   Lv, C
   Dong, J
   Sun, MY
   Chen, KX
   Xiao, Y
   Wu, ML
   Xue, CY
AF Dai, Haiying
   Wang, Yuchong
   Xu, Jianguo
   Lv, Chuan
   Dong, Jie
   Sun, Mengyan
   Chen, Kexin
   Xiao, Yuai
   Wu, Minliang
   Xue, Chunyu
TI Application of maple leaf-shaped flap combined with negative pressure
   wound therapy in the perianal circular skin defect reconstruction
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE maple leaf-shaped flap; negative pressure wound therapy; perianal
   region; wound repair
ID EXTRAMAMMARY PAGETS-DISEASE; WIDE LOCAL EXCISION; ROTATION FLAP;
   PERINEAL; CLOSURE; REGION; REPAIR
AB We aimed to explore the efficacy of maple leaf-shaped flap in the repair of perianal circular skin defect. This study is a retrospective review of patients with perianal circular skin defect after skin tumour resection and repaired with maple leaf-shaped flap. Patients included in this study were admitted in our department between January 2010 and January 2023. A standardized data collection template was used to collect related variables. The design and surgical procedures of maple leaf-shaped flap are carefully described in this study. Negative pressure wound therapy (NPWT) was applied to assist wound healing postoperatively. Twenty-seven patients were included in this study. The average wound size after tumour resection measured 4 x 5 cm2-10 x 10 cm2. The circular skin defect was repaired by maple leaf-shaped flap, and NPWT was used after surgery. Twenty-five patients achieved primary wound healing and flaps were well-survived. Slight infection occurred in two patients, and both were cured after dressing change. During the follow-up period of 6-24 months, no tumour recurrence occurred. The perianal morphology can be well-restored by maple leaf-shaped flap, and the defecation control function of anus was not impaired. The application of maple leaf-shaped flap and NPWT is a promising way in the repair of perianal circular skin defect with little complication and satisfying outcomes.
C1 [Dai, Haiying; Wang, Yuchong; Xu, Jianguo; Lv, Chuan; Dong, Jie; Sun, Mengyan; Chen, Kexin; Xiao, Yuai; Wu, Minliang; Xue, Chunyu] Naval Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai, Peoples R China.
   [Wu, Minliang] Naval Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
   [Xue, Chunyu] Naval Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Naval Medical University; Naval Medical
   University
RP Wu, ML (通讯作者)，Naval Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.; Xue, CY (通讯作者)，Naval Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM wml9398@163.com; xcyfun@sina.com
RI Chen, KeXin/M-5657-2017; Wu, Minliang/GPT-4264-2022; Xu,
   Jian-Guo/JZD-9552-2024
OI Xu, Jian-Guo/0000-0003-2514-5057
CR Conklin A, 2009, J GASTROINTEST SURG, V13, P951, DOI 10.1007/s11605-009-0822-x
   Desvigne M, 2023, WOUNDS, V35, pE173, DOI 10.25270/wnds/20167
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   Hassan I, 2001, AM J SURG, V181, P363, DOI 10.1016/S0002-9610(01)00578-5
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NR 20
TC 0
Z9 0
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JAN 31
PY 2024
VL 21
IS 2
AR e14643
DI 10.1111/iwj.14643
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GK6Y1
UT WOS:001152614300001
PM 42052877
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mizutani, Y
   Tamai, S
   Nakamura, T
   Hagiwara, Y
   Takita, T
   Kawamura, K
AF Mizutani, Yasushi
   Tamai, Susumu
   Nakamura, Toshifumi
   Hagiwara, Yusuke
   Takita, Takehiko
   Kawamura, Kenji
TI Conservative treatment of traumatic finger amputations using
   negative-pressure wound therapy
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Wound therapy; amputation; negative pressure
ID REPLANTATION
AB Replantation is widely regarded as the first choice of treatment for finger amputations. However, if the fingertip of a traumatic finger amputation is missing after an injury, the following procedures are often performed to reconstruct this portion: flap surgery, stump surgery, or conservative treatment, including occlusive dressings. To our knowledge, no existing English literature reports using negative-pressure wound therapy (NPWT) to treat traumatic finger amputations.
   We postulated that NPWT may be applied as a conservative treatment for traumatic finger amputations, promoting the growth of granulation tissue and achieving early epithelialization of the fingertips.
   Among the case series of five patients, we included six injured fingers comprising two index, two middle, and two ring fingers. The fingertip of each traumatic finger amputation was either missing or highly crushed, making replantation impossible. To preserve finger length with conservative treatment, we adapted an NPWT device for finger amputations. It took an average of 22.7 days for the fingertips to epithelialize. Immediately after epithelialization, there was a slight decrease in sensory perception; however, all patients showed good recovery of sensory perception after 3 months. Range of motion remained unrestricted, with no reduction in grip strength. Patients were highly satisfied with their fingertip appearance. The regenerated nail exhibited slight deformation and shortening. No complications were observed.
   Our novel study regarding this new conservative treatment and its outcomes revealed that healing was achieved in a relatively short period; therefore, NPWT may serve as a new conservative treatment option in the future.
C1 [Mizutani, Yasushi; Hagiwara, Yusuke; Takita, Takehiko] Takita Hosp, Orthoped Clin, Yamato Kohriyama Shi, Nara, Japan.
   [Tamai, Susumu; Nakamura, Toshifumi] Takita Hosp, Nara Hand Surg Inst, Nara, Japan.
   [Kawamura, Kenji] Nara Med Univ, Dept Orthoped Surg, 840 Shijyo Cho, Kashihara, Nara 6348522, Japan.
C3 Nara Medical University
RP Kawamura, K (通讯作者)，Nara Med Univ, Dept Orthoped Surg, 840 Shijyo Cho, Kashihara, Nara 6348522, Japan.
EM kkenji@naramed-u.ac.jp
RI Hagiwara, Yusuke/JBJ-0337-2023; Kawamura, Kenji/NFT-9921-2025
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 10
TC 2
Z9 3
U1 0
U2 1
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PY 2023
VL 58
BP 115
EP 118
DI 10.2340/jphs.v58.18351
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA HE4Z2
UT WOS:001157817200019
PM 37768149
OA gold
DA 2026-07-24
ER
PT J
AU Bhardwaj, H
   Joshi, R
   Gupta, A
AF Bhardwaj, Harish
   Joshi, Renjil
   Gupta, Anshita
TI Updated Scenario on Negative Pressure Wound Therapy
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE negative pressure wound therapy; wound healing; vacuum-assisted closer
   (VAC); chronic wound
ID DRESSINGS
AB Negative pressure wound therapy (NPWT) is a widely used and effective treatment for managing complex wounds. This document discusses how NPWT can be used in wound care in an updated way. The updated scenario on NPWT provides a concise overview of the current state of NPWT and its implications in clinical practice. It highlights recent developments in NPWT, as well as the advancements in this field. As part of NPWT, vacuum-assisted closure is used and negative pressure is applied to the wound bed. It discusses the key components and mechanisms. In addition to improving wound healing, NPWT also reduces infection rates and improves patient comfort, among other benefits. In addition, this document discusses the specific indications and contraindications of NPWT, as well as the types of wounds that can be treated with NPWT, including diabetic foot ulcers, pressure ulcers, and traumatic wounds. The document emphasizes the importance of choosing patients appropriately and assessing wounds to ensure optimal outcomes. In addition, it provides evidence-based guidelines and clinical recommendations on NPWT. In addition to reviewing the latest research findings supporting NPWT in a variety of clinical settings, it also discusses randomized controlled trials and systematic reviews. In addition, it discusses the potential complications and challenges associated with NPWT, including pain, bleeding, and device malfunction. The purpose of this document is to shed light on the role of NPWT in wound care management by providing an updated scenario. NPWT can be incorporated into clinical practice by healthcare professionals if they understand its principles, benefits, indications, and limitations. Healthcare providers can optimize patient outcomes and improve wound healing in diverse patient populations by staying abreast of the latest advancements in NPWT.
C1 [Bhardwaj, Harish] Pt Ravishankar Shukla Univ, Univ Inst Pharm, Raipur 492010, CG, India.
   [Joshi, Renjil] Rungta Coll Pharmaceut Sci & Res Bhilai, Kohka Kurud, Chhatisgarh, India.
   [Gupta, Anshita] Rungta Coll Pharmaceut Sci & Res Nandanvan, Raipur, Chhattisgarh, India.
C3 Pt. Ravishankar Shukla University
RP Bhardwaj, H (通讯作者)，Pt Ravishankar Shukla Univ, Univ Inst Pharm, Raipur 492010, CG, India.
EM harishbhardwaj808@gmail.com
RI Gupta Soni, Anshita/AAN-5226-2020; Bhardwaj, Harish/KPA-1383-2024
OI Gupta Soni, Anshita/0000-0002-9763-6915; Bhardwaj,
   Harish/0000-0001-5080-9471
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NR 31
TC 7
Z9 7
U1 1
U2 21
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD JUN
PY 2026
VL 25
IS 2
BP 284
EP 292
DI 10.1177/15347346241228788
EA JUN 2026
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IF7KA
UT WOS:001157835200001
PM 38327069
DA 2026-07-24
ER
PT J
AU Jeon, JH
   Kim, KW
   Jeon, HB
AF Jeon, Jae Hyung
   Kim, Kyung Wook
   Jeon, Hong Bae
TI Pedicled abdominal flap using deep inferior epigastric artery
   perforators for forearm reconstruction: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Forearm injury; Open fracture reduction; Perforator flap; Deep inferior
   epigastric artery perforators; Case report
ID GROIN
AB BACKGROUND Pedicled abdominal flaps are a widely used surgical technique for forearm reconstruction in patients with soft tissue defects. However, some drawbacks include restricted flap size, partial flap loss, and donor-site morbidity. To address these concerns, we present a case of a pedicled abdominal flap using the deep inferior epigastric artery perforators (DIEP) for forearm reconstruction in a patient with a large soft tissue defect. CASE SUMMARY A 46-year-old male patient was admitted to our hospital with forearm injury caused by a pressing machine. A 15 cm x 10 cm soft tissue defect with complete rupture of the ulnar side structures of the forearm was found. One week after orthopedic management of the neurovascular injury and fractures using the first stage of Masquelet technique, the patient was referred to the plastic and reconstructive surgery department for wound coverage. Surgical debridement and negative-pressure wound therapy revealed a 20 cm x 15 cm soft tissue defect. A pedicle abdominal flap with the DIEP was used to cover the defect. Three weeks later, the flap was detached from the abdomen, and the abdominal defect was directly closed. Subsequently, the second stage of Masquelet technique was performed at the fracture site at week 10. Finally, all donor and recipient sites healed without complications, such as flap dehiscence, infection, hematoma, or necrosis. Fracture site osteosynthesis was achieved without complications. CONCLUSION Pedicled abdominal flap using the DIEP provides a reliable option for forearm reconstruction in patients with large soft tissue defects.
C1 [Jeon, Jae Hyung] Dankook Univ Hosp, Dept Plast & Reconstruct Surg, Cheonan 31116, Chungnam, South Korea.
   [Kim, Kyung Wook] Dankook Univ, Coll Med, Dankook Univ Hosp, Dept Orthopaed Surg, Cheonan 31116, Chungnam, South Korea.
   [Jeon, Hong Bae] Dankook Univ, Dankook Univ Hosp, Coll Med, Dept Plast & Reconstruct Surg, 201 Manghyang Ro, Cheonan 31116, Chungnam, South Korea.
C3 Dankook University; Dankook University Hospital; Dankook University;
   Dankook University Hospital; Dankook University; Dankook University
   Hospital
RP Jeon, HB (通讯作者)，Dankook Univ, Dankook Univ Hosp, Coll Med, Dept Plast & Reconstruct Surg, 201 Manghyang Ro, Cheonan 31116, Chungnam, South Korea.
EM jeonhb110@dankook.ac.kr
RI Jeon, Hong-Bae/LFU-4551-2024
FU Bio&Medical Technology Development Program of the National Research
   Foundation (NRF) - Korean government (MSIT) [RS-2023-00220408]
FX Supported by The Bio & Medical Technology Development Program of the
   National Research Foundation (NRF) funded by the Korean government
   (MSIT), No. RS-2023-00220408.
CR Adidharma Widya, 2022, J Hand Surg Glob Online, V4, P367, DOI [10.1016/j.jhsg.2022.07.005, 10.1016/j.jhsg.2022.07.005]
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NR 9
TC 0
Z9 1
U1 0
U2 1
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD FEB 6
PY 2024
VL 12
IS 4
DI 10.12998/wjcc.v12.i4.828
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HG1J1
UT WOS:001158244600011
PM 38322698
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Benzar, I
   Levytskyi, A
   Khrapach, V
   Unukovych, D
AF Benzar, Iryna
   Levytskyi, Anatolii
   Khrapach, Vasyl
   Unukovych, Dmytro
TI Warzone pediatric trauma care: Lessons from civilian medical staff in
   Kyiv
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
DE children multidisciplinary hospital; negative pressure wound therapy;
   pediatric military trauma; war in Ukraine
ID WAR
AB Introduction: The article discusses the challenges faced by civilian healthcare providers in Kyiv, Ukraine, during the conflict in treating pediatric trauma resulting from war-related incidents. Methods: The authors share their experiences and insights from managing a series of 12 pediatric patients admitted to the Ohmatdyt children's hospital between February 25 and April 1, 2022. During this period, the hospital was under constant threat due to the military conflict. Results: The patients, ranging in age from 3 months to 17 years, suffered injuries from various causes, including vehicle shootings, explosions, and other traumatic events. The interventions and timely management are discussed, and two detailed clinical cases are presented to illustrate the complexities of treating pediatric trauma in a warzone. Conclusion: In summary, the article sheds light on the unique challenges faced by healthcare providers in a warzone when treating pediatric trauma. It underscores the importance of timely intervention, effective triage, and the utilization of advanced medical techniques to improve patient outcomes in such challenging circumstances.
C1 [Benzar, Iryna; Levytskyi, Anatolii] Bogomolets Natl Med Univ, Dept Pediat Surg, Kiev, Ukraine.
   [Khrapach, Vasyl; Unukovych, Dmytro] Bogomolets Natl Med Univ, Dept Pediat Surg, Kiev, Ukraine.
   [Unukovych, Dmytro] Karolinska Univ Hosp, Dept Plast & Craniofacial Surg, NB06, S-17164 Stockholm, Sweden.
C3 Bogomolets National Medical University; Bogomolets National Medical
   University; Karolinska Institutet; Karolinska University Hospital
RP Unukovych, D (通讯作者)，Karolinska Univ Hosp, Dept Plast & Craniofacial Surg, NB06, S-17164 Stockholm, Sweden.
EM unukovych@gmail.com
RI Benzar, Iryna/ABU-0165-2022; Unukovych, Dmytro/AAW-6450-2020
OI Unukovych, Dmytro/0000-0002-1357-9125
CR Bitterman Y, 2016, MIL MED, V181, P849, DOI 10.7205/MILMED-D-15-00427
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   Samuel N, 2021, J TRAUMA ACUTE CARE, V90, pE1, DOI 10.1097/TA.0000000000002974
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NR 13
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD MAR
PY 2024
VL 48
IS 3
BP 540
EP 546
DI 10.1002/wjs.12091
EA FEB 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KL7D3
UT WOS:001158246100001
PM 38319195
DA 2026-07-24
ER
PT J
AU Cheng, L
   Du, WL
   Zhang, Y
   Chen, Z
   Shen, YM
AF Cheng, Lin
   Du, Wei-Li
   Zhang, Ying
   Chen, Zhong
   Shen, Yu-ming
TI Application of Staged Negative Pressure Wound Therapy and Flap Surgery
   for Infection Control After Patellar Internal Fixation Surgery
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Infection; internal fixation; NPWT; patella; pedicled flaps
ID PERFORATOR FLAP; RECONSTRUCTION; KNEE; COMPLICATIONS; REOPERATION;
   FRACTURES; NONUNION; DEFECTS
AB The anatomic position of the patella is superficial, making it vulnerable to injuries. Treatment of patella infection after internal fixation surgery remains a big challenge due to minimal soft tissue coverage and vital tissue exposure. Forty-two patients aged 10 to 59 years were admitted to the institution's burn unit between January 2010 and December 2019. Each presented with infection after patellar fracture surgery. Twenty-seven infections were superficial, whereas 15 were deep with pyogenous arthritis of the knee. Negative pressure wound therapy (NPWT) was applied after radical debridement to remove necrotic subcutaneous tissues and internal fixation devices. In addition, cases with septic arthritis were irrigated continuously with normal saline. After 5 to 10 days of NPWT treatment and irrigation, wound infection was well controlled. Afterward, 42 wounds were resurfaced with pedicled flaps, the 42 patients received 17 reverse-flow anterolateral thigh (ALT) perforator flap, 12 medial sural artery perforator flaps, 7 gastrocnemius musculocutaneous flaps, as well as 6 saphenous artery flaps. Thirty-seven flaps survived uneventfully. However, 3 flaps developed venous congestion in the distal end. Two flaps developed tip necrosis. All patients were followed up between 3 and 48 months. Infection beneath the flap occurred in 3 patients and healed after an additional debridement surgery. The staged NPWT and flap surgery strategy focus on thorough debridement and immediate internal fixation devices removal, effective fracture fixation, efficient NPWT application, targeted administration of antibiotics, and adequate soft tissue coverage. This study established that the procedure was effective in infection control after patellar internal fixation surgery.
C1 [Cheng, Lin; Du, Wei-Li; Zhang, Ying; Chen, Zhong; Shen, Yu-ming] Beijing Jishuitan Hosp, Dept Burns & Plast Surg, Beijing 100035, Peoples R China.
RP Shen, YM (通讯作者)，Beijing Jishuitan Hosp, Dept Burns & Plast Surg, Beijing 100035, Peoples R China.
EM chenglin5407@126.com; 670816419@qq.com; 542452728@qq.com;
   zhangcongjst@126.com; shenyumingjst@126.com
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NR 22
TC 0
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD JAN-FEB
PY 2024
VL 35
IS 1
BP 74
EP e78
DI 10.1097/SCS.0000000000009854
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HH5K0
UT WOS:001158612900026
PM 37982783
DA 2026-07-24
ER
PT J
AU Senturk, A
   Gonullu, E
   Bayhan, Z
   Akdeniz, Y
   Ozdemir, K
   Mantoglu, B
   Capoglu, R
   Firat, N
   Altintoprak, F
AF Senturk, A.
   Gonullu, E.
   Bayhan, Z.
   Akdeniz, Y.
   Ozdemir, K.
   Mantoglu, B.
   Capoglu, R.
   Firat, N.
   Altintoprak, F.
TI The wound area as a parameter guiding the timing of abdominal closure in
   the management of patients undergoing open abdominal procedures
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Abstract. - OBJECTIVE: Surgical site infec-; Open abdomen;
   Vacuum-assisted closure; Wound
ID NEUTROPHIL-LYMPHOCYTE RATIO; INFLAMMATORY RESPONSE; PREDICTIVE-VALUE;
   STRATEGIES; OUTCOMES; THERAPY; TRIAL
AB Objective: Surgical site infections (SSI) are incomparably troublesome and complicated, and some of them require an open abdomen (OA) procedure. While deciding the timing of abdominal closure, wound area calculation method and laboratory parameters can be used to guide the timing of abdominal closure after OA procedures. Patients and methods: The records of the patients who had undergone open abdomen during their treatment course and were followed up with vacuum-assisted closure (VAC) technique between December 2015 and December 2019 were retrospectively analyzed. The laboratory results before the first VAC application and the results after the VAC change were compared to determine a predictive parameter. The ImageJ program was used in five patients to compare the size of the wounds at the time of the decision to close them and before the first VAC application. Results: 102 patients were analyzed. The ratio of the last wound area to the wound area at the time of the first VAC application in five patients was 0.30, 0.41, 0.34, 0.27, 0.46 (mean: 0.36, standard deviation: 0.078) which were measured and calculated by ImageJ software. Conclusions: We think that the concept of wound reduction ratio, which was calculated by a computer program, can be used as a concrete equivalent of the wound closure eligibility criteria decided by clinical experience.
C1 [Senturk, A.; Gonullu, E.; Ozdemir, K.; Capoglu, R.] Sakarya Univ Training, Res Hosp, Gen Surg Dept, Sakarya, Turkiye.
   [Bayhan, Z.; Akdeniz, Y.; Mantoglu, B.; Firat, N.; Altintoprak, F.] Sakarya Univ, Gen Surg Dept, Fac Med, Sakarya, Turkiye.
C3 Sakarya University
RP Senturk, A (通讯作者)，Sakarya Univ Training, Res Hosp, Gen Surg Dept, Sakarya, Turkiye.
EM adem.senturk@saglik.gov.tr
RI Altintoprak, Fatih/JCD-8434-2023; CAPOGLU, Recayi/HKE-6308-2023;
   Şentürk, Adem/JNE-1643-2023; Mantoglu, Baris/ABD-2975-2020; Bayhan,
   Zulfu/AAB-8502-2020; GONULLU, Emre/AAK-7837-2021
OI Mantoglu, Baris/0000-0002-2161-3629; Bayhan, Zulfu/0000-0002-7587-7267;
   GONULLU, Emre/0000-0001-6391-4414
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NR 36
TC 0
Z9 0
U1 0
U2 16
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD DEC
PY 2023
VL 27
IS 23
BP 11361
EP 11369
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HK2X0
UT WOS:001159340600020
PM 38095385
DA 2026-07-24
ER
PT J
AU Yuan, Y
   Zhong, X
   Zhang, J
   Shen, CM
   Huang, GX
   Zhang, JC
   Wang, K
   Xu, M
   Shao, S
   Yang, J
   Qian, D
AF Yuan, Yuan
   Zhong, Xian
   Zhang, Jian
   Shen, Chunming
   Huang, Guoxin
   Zhang, Jianchao
   Wang, Ke
   Xu, Ming
   Shao, Sheng
   Yang, Jun
   Qian, Da
TI Artificial dermis combined with split-thickness skin autograft in the
   treatment of hand thermal compression wounds: a single center
   case-control study
SO FRONTIERS IN SURGERY
LA English
DT Article
DE artificial dermis; thermal compression wound; wound repair; graft;
   vacuum sealing drainage technology
AB Objective: To explore the clinical effect of artificial dermis combined with split-thickness skin autograft in treating hand thermal compression wounds. Methods: Forty-two patients in our hospital from January 2016 to October 2022 with thermal compression wounds were divided into two groups. The survival rate of autologous skin grafts seven days after skin grafting, the number of operations, total hospital stay, total hospitalization cost, and bacterial culture results of secretions were recorded. The visual analog scale was used to evaluate the wound pain. The condition of skin graft rupture was recorded and the scar status of the donor site was evaluated by the Vancouver Scar Scale. Results: It showed combination of artificial dermis, split-thickness skin autograft, and vacuum sealing drainage improves the treatment of hand thermal compression wounds by enhancing the survival rate of skin grafting (95.24% > 66.67%), reducing the number of operations (P < 0.001), relieving wound pain (P < 0.001), effectively controlling wound infection (4.76% < 9.52%), and reducing the skin graft rupture rate after surgery (4.8% < 28.6%). There was no evident scar hyperplasia in the donor (P = 0.003) and skin graft areas (P < 0.001), which had a good recovery of hand function (P = 0.037); however, this treatment strategy may prolong the hospital stay (P = 0.030) and increase the total hospitalization cost (P = 0.030). Conclusion: The composite transplantation of artificial dermis and split-thickness skin combined with the VSD significantly improves treatment and aesthetic outcomes in patients with thermal compression wounds to the hand, which is worth promoting and applying in clinical practice.
C1 [Yuan, Yuan; Zhong, Xian; Zhang, Jian; Shen, Chunming; Zhang, Jianchao; Wang, Ke; Xu, Ming; Shao, Sheng; Qian, Da] Soochow Univ, Changshu Peoples Hosp 1, Changshu Hosp, Dept Burn & Plast Surg Hand Surg, Changshu, Peoples R China.
   [Huang, Guoxin] Hubei Univ Med, Xiangyang Peoples Hosp 1, Based Med Ctr, Dept Evidence, Xiangyang, Peoples R China.
   [Yang, Jun] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, Shanghai, Peoples R China.
C3 Soochow University - China; Hubei University of Medicine; Shanghai Jiao
   Tong University
RP Shao, S; Qian, D (通讯作者)，Soochow Univ, Changshu Peoples Hosp 1, Changshu Hosp, Dept Burn & Plast Surg Hand Surg, Changshu, Peoples R China.; Yang, J (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, Shanghai, Peoples R China.
EM ss-0603@163.com; yangj1580@sh9hospital.org.cn; drqianda@hotmail.com
RI Qian, Da/AFD-8353-2022; Zhang, Jian/MTA-2037-2025
OI Qian, Da/0000-0002-6062-8161; 
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NR 33
TC 5
Z9 8
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD DEC 22
PY 2023
VL 10
AR 1304333
DI 10.3389/fsurg.2023.1304333
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HR1V3
UT WOS:001161150700001
PM 38186394
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Elhassan, H
   Amjad, R
   Palaniappan, U
   Loubani, M
   Rose, D
AF Elhassan, Hind
   Amjad, Ridha
   Palaniappan, Unna
   Loubani, Mahmoud
   Rose, David
TI The negative pressure wound therapy for prevention of sternal wound
   infection: Can we reduce infection rate after the use of bilateral
   internal thoracic arteries? A systematic literature review and
   meta-analysis
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Review
DE Negative pressure wound therapy; Bilateral internal mammary artery;
   Sternal wound infections; Coronary artery bypass grafting
ID INCISION MANAGEMENT; RISK-FACTORS; SURVIVAL; GRAFTS
AB Background Negative pressure wound therapy (NPWT) is traditionally used to treat postoperative wound infections. However, its use in closed wound sternotomy post cardiac surgery in high-risk patients has become increasingly popular. The potential preventive benefit of reducing sternal wound infections has been recently acknowledged. Bilateral internal mammary artery (BIMA) grafts are used in coronary artery bypass grafting but have been associated with an increased risk of sternal wound infections (SWIs). Objectives This systematic analysis examines whether NPWT can reduce the incidence of SWI following BIMA grafts, leading to more patients benefiting from the better survival outcome associated with BIMA grafting. MethodA comprehensive systematic search and meta-analysis were performed to identify studies on the use of NPWT in closed wound sternotomy. Ovid MEDLINE (in-process and other nonindexed citations and Ovid MEDLINE 1990 to present), Ovid EMBASE (1990 to present), and The Cochrane Library (Wiley), PubMed, and Google Scholar databases were searched from their inception to May 2022 using keywords and MeSH terms. Thirty-four articles from 1991 to May 2022 were selected. Result Three studies reported on the outcome of NPWT following BIMA grafting. The pooled analysis did not show any significant difference in the incidence of sternal wound infection between NPWT and standard dressing (RR 0.48 95% CI 0.17-1.37; P = 0.17) with substantial heterogeneity (I2 65%). Another seven studies were found comparing the outcome of SWI incidence of negative pressure closed wound therapy with conventional wound therapy in patients undergoing adult cardiac surgery. The pooled analysis showed that NPWT was associated with a low risk of SWIs compared to conventional dressing (RR 0.47 95% CI 0.36-0.59; P < 0.00001), with low heterogeneity (I2 1%). Conclusion The literature identified that NPWT significantly decreased the incidence of sternal wound complications when applied to sutured sternotomy incisions in high-risk patients, and in some cases, it eliminated the risk. However, the inadequate number of randomized controlled trials assessing the effectiveness of NPWT in BIMA grafting emphasizes the need for further, robust studies.
C1 [Elhassan, Hind; Loubani, Mahmoud] Hull Univ Teaching Hosp NHS Fdn Trust, Cardiothorac Dept, Castle Rd, Cottingham HU16 5JQ, East Riding Of, England.
   [Amjad, Ridha; Palaniappan, Unna] Univ Lancaster, Lancaster Med Sch, Lancaster, England.
   [Rose, David] Blackpool Teaching Hosp NHS Fdn Trust, Lancashire Cardiac Ctr, Cardiothorac Dept, Blackpool, England.
C3 Lancaster University
RP Elhassan, H (通讯作者)，Hull Univ Teaching Hosp NHS Fdn Trust, Cardiothorac Dept, Castle Rd, Cottingham HU16 5JQ, East Riding Of, England.
EM hind.elhassan@nhs.net
RI Rose, David/OSH-8476-2025
CR [Anonymous], New study demonstrates PICO Single Use Negative Pressure Wound Therapy System (sNPWT) beats standard dressings in reducing surgical site complications resulting in fewer deep sternal wound infections (DSWI) following cardiac surgery
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NR 39
TC 5
Z9 7
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD FEB 12
PY 2024
VL 19
IS 1
AR 87
DI 10.1186/s13019-024-02589-y
PG 10
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA HR3G6
UT WOS:001161188000001
PM 38342923
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, JH
   Jiang, DW
   Chang, ZQ
AF Li, Jianhua
   Jiang, Dawei
   Chang, Zhengqi
TI Investigating the efficacy of vacuum sealing drainage versus traditional
   negative pressure drainage in treating deep incision infections
   following posterior cervical internal fixation-a retrospective cohort
   study
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Cervical spondylosis; Deep incision infections(DII); Posterior cervical
   internal fixation; Vacuum sealing drainage (VSD); Traditional negative
   pressure drainage (TND)
ID SURGICAL SITE INFECTION; SPINAL INSTRUMENTATION; WOUND-INFECTION;
   RISK-FACTORS; ASSISTED CLOSURE; SURGERY; IRRIGATION; THERAPY; FUSION
AB Background Assessing the efficacy and safety of Vacuum Sealing Drainage (VSD) in treating deep incision infections (DII) following posterior cervical internal fixation. Methods We retrospectively studied the clinical effects of VSD and Traditional Negative Pressure Drainage (TND) on 12 patients with deep incision infection after posterior cervical fixation surgery who were treated in our department from 2012 to 2020. A comparison of patient-related factors (age, gender, BMI, comorbidities, initial internal fixation surgery segment, preoperative laboratory inflammation indicators) and surgical-related factors (postoperative duration of fever, positive rate of drainage fluid bacterial culture, Visual Analogue Scale (VAS) score at 3 days after surgery, laboratory indicators at 3 days after surgery, debridement frequency and drainage time, hospital stay, internal fixation retention rate, and infection recurrence rate) between the VSD group and the TND group was conducted using independent sample t tests to draw experimental conclusions. Results This study included 12 patients, with six cases of VSD (5 males and 1 female) and six cases of TND (4 males and 2 females). The VSD group had significantly lower postoperative fever time (1.50 +/- 0.46 days vs. 4.28 +/- 0.97 days, P < 0.05), a higher positive rate of bacterial cultures in drainage fluid (5/6 vs. 2/6, P < 0.05), lower 3 day VAS scores (3.13 +/- 0.83 vs. 3.44 +/- 0.88, P < 0.05), lower 3 day CRP levels (66.89 +/- 23.65 mg/L vs. 57.11 +/- 18.18 mg/L, P < 0.05), a shorter total drainage time (14.50 +/- 2.98 days vs. 22.56 +/- 3.01 days, P < 0.05), and a higher total drainage flow rate (395.63 +/- 60.97 ml vs. 155.56 +/- 32.54 ml, P < 0.05) than the TND group (the total drainage volume throughout the entire treatment process). In addition, the frequency of debridement (2.67 +/- 0.52 times vs. 3.17 +/- 0.41 times, P < 0.05) and average hospital stay (23.13 +/- 3.27 days vs. 34.33 +/- 6.86 days, P < 0.05) were significantly lower in the VSD group, although both groups retained internal fixation. Conclusions VSD is a secure and effective treatment for deep incision infections that results from cervical posterior internal fixation surgery. Background
C1 [Li, Jianhua; Jiang, Dawei; Chang, Zhengqi] 960th Hosp PLA, Dept Orthopaed Surg, Shifan Rd, Jinan 250031, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthopaed Surg, Shifan Rd, Jinan 250031, Peoples R China.
EM 26766771@qq.com
RI Jiang, Dawei/J-6148-2019
FU Natural Science Foundation of Shandong Province
FX Not applicable.
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   Zeng JK, 2019, WORLD NEUROSURG, V127, pE389, DOI 10.1016/j.wneu.2019.03.130
   Zhang XL, 2023, INT WOUND J, V20, P768, DOI 10.1111/iwj.13921
   Zhang XX, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000028836
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   Zhu WD, 2022, SCI TRANSL MED, V14, DOI 10.1126/scitranslmed.abk1707
NR 37
TC 4
Z9 5
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD FEB 15
PY 2024
VL 29
IS 1
AR 125
DI 10.1186/s40001-024-01717-7
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HZ7G4
UT WOS:001163394300003
PM 38360845
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Brozmanová, H
   Sistík, P
   Duricová, J
   Kacírová, I
   Kanková, K
   Kolek, M
AF Brozmanova, Hana
   Sistik, Pavel
   Duricova, Jana
   Kacirova, Ivana
   Kankova, Klara
   Kolek, Martin
TI Liquid chromatography-tandem mass spectrometry methods for
   quantification of total and free antibiotic concentrations in serum and
   exudate from patients with post-sternotomy deep sternal wound infection
   receiving negative pressure wound therapy
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Total and free antibiotic concentration; Method validation; Serum;
   Exudate; Cardiac surgery; Negative pressure wound therapy
ID BETA-LACTAM ANTIBIOTICS; UHPLC-MS/MS METHOD; HUMAN PLASMA;
   ULTRAFILTRATION IMPACT; UNBOUND FRACTION; VANCOMYCIN; PIPERACILLIN;
   TAZOBACTAM; PHARMACOKINETICS; CIPROFLOXACIN
AB Background: Systemically administered antibiotics are thought to penetrate the wounds more effectively during negative pressure wound therapy (NPWT).To test this hypothesis total and free antibiotic concentrations were quantified in serum and wound exudate.
   Methods: UHPLC-MS/MS methods were developed and validated for the determination of ceftazidime, cefepime, cefotaxime, cefuroxime, cefazolin, meropenem, oxacillin, piperacillin with tazobactam, clindamycin, ciprofloxacin, sulfamethoxazole/trimethoprim (cotrimoxazole), gentamicin, vancomycin, and linezolid. The unbound antibiotic fraction was obtained by ultrafiltration using a Millipore Microcon-30kda Centrifugal Filter Unit. Analysis was performed on a 1.7-mu m Acquity UPLC BEH C18 2.1 x 100-mm column with a gradient elution.
   Results: The validation was performed for serum, exudates and free fractions. For all matrices, requirements were met regarding linearity, precision, accuracy, limit of quantitation, and matrix effect. The coefficient of variation was in the range of 1.2-13.6%.and the recovery 87.6-115.6%, respectively. Among the 29 applications of antibiotics thus far, including vancomycin, clindamycin, ciprofloxacin, oxacillin, cefepime, cefotaxime, cotrimoxazole, and gentamicin, total and free antibiotic concentrations in serum and exudate were correlated.
   Conclusion: This method can accurately quantify the total and free concentrations of 16 antibiotics. Comparison of concentration ratios between serum and exudates allows for monitoring individual antibiotics' penetration capacity in patients receiving NPWT.
C1 [Brozmanova, Hana; Sistik, Pavel; Duricova, Jana; Kacirova, Ivana] Univ Hosp Ostrava, Inst Lab Med, Dept Clin Pharmacol, 17 Listopadu 1790, Ostrava 70852, Czech Republic.
   [Brozmanova, Hana; Sistik, Pavel; Duricova, Jana; Kacirova, Ivana] Univ Ostrava, Fac Med, Dept Clin Pharmacol, Syllabova 19, Ostrava 70300, Czech Republic.
   [Kankova, Klara; Kolek, Martin] Univ Hosp Ostrava, Dept Cardiac Surg, 17 Listopadu 1790, Ostrava 70852, Czech Republic.
   [Kolek, Martin] Univ Ostrava, Fac Med, Dept Clin Subjects, Syllabova 19, Ostrava 70300, Czech Republic.
C3 University Hospital Ostrava; University of Ostrava; University of
   Ostrava
RP Sistík, P (通讯作者)，Univ Hosp Ostrava, Inst Lab Med, Dept Clin Pharmacol, 17 Listopadu 1790, Ostrava 70852, Czech Republic.
RI Kolek, Martin/D-4115-2018; Brozmanova, ./G-9793-2019
OI Kolek, Martin/0000-0002-0418-3006; 
FU MH CZ-DRO [FNOs/2021]
FX Supported by by MH CZ-DRO (FNOs/2021) .
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   Rowan MP, 2017, ADV WOUND CARE, V6, P55, DOI 10.1089/wound.2016.0698
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   SUKL Prehled leciv, about us
   Wong G, 2013, ANTIMICROB AGENTS CH, V57, P6165, DOI 10.1128/AAC.00951-13
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NR 44
TC 8
Z9 8
U1 1
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD FEB 1
PY 2024
VL 554
AR 117704
DI 10.1016/j.cca.2023.117704
EA JAN 2024
PG 10
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA IP4F4
UT WOS:001167513100001
PM 38185284
DA 2026-07-24
ER
PT J
AU Akbayrak, H
   Tekumit, H
AF Akbayrak, Hakan
   Tekumit, Hayrettin
TI Comparison between Vacuum-Assisted Closure Technique and Conventional
   Approach in Patients with Mediastinitis After Isolated Coronary Artery
   Bypass Graft Surgery
SO BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE Coronary Artery Bypass; Mediastinitis. Treatment; Vacuum-Assisted
   Closure
ID RISK-FACTORS; STERNOTOMY; INFECTION
AB Introduction: Median sternotomy is the most preferred approach in heart surgery. Post-sternotomy mediastinitis is a catastrophic and potentially life-threatening complication with an incidence rate of 0.15% to 5%, and its overall mortality rate reaches 47%. In this study, we aimed to compare the results of vacuum-assisted closure technique and the conventional methods on the management of mediastinitis following isolated coronary artery bypass graft surgery.
   Methods: Between February 2001 and July 2013, 32,106 patients who underwent cardiac operations were evaluated retrospectively. One hundred and fourteen patients who developed post-sternotomy mediastinitis were included in this study. The patients were divided into two groups and compared - vacuum-assisted closure group (n= 52, 45.6%) and conventional treatment group (n=62, 54.4%).
   Results: There were no differences between the two groups according to the patients' characteristics, surgical data, and mediastinal cultures. However, we found that total treatment duration for post-sternotomy mediastinitis, time interval from diagnosis to negative culture, hospitalization time, and in-hospital mortality were statistically significantly lower in the vacuum-assisted closure group than in the conventional treatment group (P<0.001, P<0.001, P<0.001, and P=0.03, respectively).
   Conclusion: This study demonstrates that the vacuum-assisted closure technique improves the medical outcome of patients with post- sternotomy mediastinitis compared with the conventional treatment. The vacuum-assisted closure is a safe and more effective treatment modality for patients with post-sternotomy mediastinitis after cardiac surgery with reasonable morbidity and mortality.
C1 [Akbayrak, Hakan] Selcuk Univ, Dept Cardiovasc Surg, Fac Med, Alaaddin Keykubat Campus, TR-42131 Konya, Turkiye.
   [Tekumit, Hayrettin] Bandirma Onyedi Eylul Univ, Dept Cardiovasc Surg, Fac Med, Balikesir, Turkiye.
C3 Selcuk University; Bandirma Onyedi Eylul University
RP Akbayrak, H (通讯作者)，Selcuk Univ, Dept Cardiovasc Surg, Fac Med, Alaaddin Keykubat Campus, TR-42131 Konya, Turkiye.
EM hakanakbayrak@gmail.com
RI Akbayrak, Hakan/GLT-2080-2022
OI Akbayrak, Hakan/0000-0003-1637-6769
CR Bryan A J, 1992, J R Coll Surg Edinb, V37, P305
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NR 18
TC 6
Z9 6
U1 0
U2 2
PU SOC BRASIL CIRURGIA CARDIOVASC
PI SAO PAULO SP
PA RUA AFONSO CELSO, 1178, SAO PAULO SP, 04119-061, BRAZIL
SN 0102-7638
EI 1678-9741
J9 BRAZ J CARDIOV SURG
JI Braz. J. Cardiovasc. Surg.
PY 2023
VL 38
IS 3
BP 353
EP 359
DI 10.21470/1678-9741-2022-0317
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA IR4Q5
UT WOS:001168047500007
PM 36692043
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rollo, G
   De Angelis, P
   Torroni, F
   Balassone, V
   Contini, ACI
   Faraci, S
   Romeo, EF
   Oglio, L
   Caldaro, T
AF Rollo, Giovanni
   De Angelis, Paola
   Torroni, Filippo
   Balassone, Valerio
   Contini, Anna Chiara Iolanda
   Faraci, Simona
   Romeo, Erminia Francesca
   Dall Oglio, Luigi
   Caldaro, Tamara
TI Replogle Modified Endoscopic Vacuum-Assisted Closure (EVAC) Therapy: A
   New Strategy to Treat Anastomotic Leakage and Esophageal Perforation
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE EVAC therapy; Anastomotic leakage; Esophageal perforation; Children;
   Pediatric; Endoscopy
ID MANAGEMENT; RESECTION; OPTIONS
AB Background: Anastomotic leakage (AL) and esophageal perforation are life -threatening complications following surgery or endoscopic dilations. "Replogle modified EVAC therapy" consists of placing a Replogle tube directly into the lumen or within an abscess cavity and remove by suction all intra-cavity fluids and secretion with a continuous low-pressure suction, promoting granulation tissue proliferation, thereby gradually decreasing the cavity size. The aim of our study was to evaluate the technical feasibility, safety, and efficacy of this technique in pediatric patients. Methods: A retrospective review charts of consecutive pediatric patients that were treated with "Replogle modified EVAC therapy" at our pediatric referral center between 2013 and 2022 was conducted. The clinical, endoscopic, radiological, and surgical information and data of patients were collected and revised as well as their follow-up and outcomes. Results: Ten patients (6/10 male; mean age: 7.8 y.o., range: 1.1-18 y.o.) were treated using the "Replogle modified EVAC therapy". Four out of ten patients developed esophageal perforations after endoscopic procedures. Six out of the ten enrolled patients had AL complications after surgical operations. All patients were successfully treated. There were no technical failures or complications with device placement. Mean treatment duration was 16 days (range 7-41 days). No additional treatment was needed for complete leak resolution. Conclusions: "Replogle modified EVAC therapy" represents a promising and mini -invasive method to treat esophageal perforations and post -surgical leak in the paediatric age group. In our experience, the use of this technique was safe, effective, and particularly well suited also in complex paediatric patients. Level of evidence: IV. (c) 2023 Elsevier Inc. All rights reserved.
C1 [Rollo, Giovanni] Univ Roma Tor Vergata, Rome, Italy.
   [De Angelis, Paola; Torroni, Filippo; Faraci, Simona; Romeo, Erminia Francesca] Bambino Gesu Pediat Hosp, Gastroenterol & Nutr Unit, IRCCS, Rome, Italy.
   [Rollo, Giovanni; Balassone, Valerio; Contini, Anna Chiara Iolanda; Dall Oglio, Luigi; Caldaro, Tamara] Bambino Gesu Pediat Hosp, Digest Endoscopy & Surg Unit, IRCCS Rome, Rome, Italy.
   [Rollo, Giovanni] Bambino Gesu Pediat Hosp, Digest Endoscopy & Surg Unit, IRCCS, Rome, Italy.
C3 University of Rome Tor Vergata; IRCCS Bambino Gesu; IRCCS Bambino Gesu;
   IRCCS Bambino Gesu
RP Rollo, G (通讯作者)，Bambino Gesu Pediat Hosp, Digest Endoscopy & Surg Unit, IRCCS, Rome, Italy.
EM giovanni.rollo@opbg.net
RI Romeo, Erminia/AAA-7473-2020; torroni, filippo/AAA-6167-2020; Balassone,
   Valerio/AAW-6795-2021; caldaro, tamara/AAA-6015-2020; faraci,
   simona/AAA-7421-2020; Rollo, Giovanni/JKH-6429-2023
OI Balassone, Valerio/0000-0001-5398-4275; Rollo,
   Giovanni/0009-0004-7742-8838
FU Italian Ministry of Health with Current Research funds
FX This work was supported by the Italian Ministry of Health with "Current
   Research funds ". This study did not receive other types of grants from
   funding agencies in the public, commercial, or nonpro fit sectors. The
   authors have no financial relationships or con flicts of interest to
   disclose.
CR Aziz M, 2021, ENDOSC INT OPEN, V09, pE1371, DOI 10.1055/a-1508-5947
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NR 17
TC 4
Z9 4
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD MAR
PY 2024
VL 59
IS 3
BP 432
EP 436
DI 10.1016/j.jpedsurg.2023.09.043
EA FEB 2024
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA IR6I8
UT WOS:001168092400001
PM 37949689
DA 2026-07-24
ER
PT J
AU Ozer, AY
   Keskin, I
   Kelestemur, T
   Ayturk, N
   Ersavas, C
   Gunal, MY
AF Ozer, Aysel Y.
   Keskin, Ilknur
   Kelestemur, Taha
   Ayturk, Nilufer
   Ersavas, Cenk
   Gunal, Mehmet Y.
TI Efficacy of one-hour negative pressure wound therapy and magnetic field
   energy in wound healing
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE angiogenesis; magnetic field; negative pressure wound therapy; wound;
   wound care; wound dressing; wound healing
ID PULSED ELECTROMAGNETIC-FIELDS; VACUUM-ASSISTED CLOSURE; ANGIOGENESIS;
   OXYGEN; PROLIFERATION; VASOMOTION; EXPOSURE
AB Objective: Wound healing is an important aspect of health but needs further research to identify the effects and interactions of different treatment approaches on healing. The aims of this study were to investigate the effectiveness of one-hour negative pressure wound therapy (NPWT) and compare histological differences between one-hour NPWT and magnetic field energy (MFE) in rats on early-stage wound healing, wound size and angiogenesis. Method: Standardised wounds were created on Wistar rats that were allocated and divided into NPWT, MFE and control groups. Both treatments were applied for 1 hour/day for 10 days. Wound size, histological changes and wound area blood flow were assessed. Results: The wound size of all groups was similar on days 0, 2 and 10. The MFE group's wound size was smaller than the NPWT group on days 4, 6 and 8 (p < 0.05). Development of the granulation tissue in both the one-hour NPWT and MFE groups was greater than in the control group. Additionally, the inflammatory phase was shorter, and wounds entered the proliferative stage faster in the MFE group than both of the other groups. Conclusion: Treatment with MFE may be more effective in terms of early stage wound closure and angiogenesis. On the other hand, the NPWT group's wound area blood flow was significantly greater than the other two groups. MFE is superior to one-hour NPWT in terms of wound area and angiogenesis. Furthermore, it is worthwhile to note that one-hour NPWT increases bloodflow in the wound area, which stimulates healing.
C1 [Ozer, Aysel Y.] Marmara Univ, Hlth Sci Fac, Dept Physiotherapy & Rehabil, Istanbul, Turkiye.
   [Keskin, Ilknur] Istanbul Medipol Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkiye.
   [Kelestemur, Taha] Istanbul Medipol Univ, Regenerat & Restorat Med Res Ctr, Sch Med, Dept Physiol, Istanbul, Turkiye.
   [Ayturk, Nilufer] Canakkale Onsekiz Mart Univ, Sch Med, Dept Histol & Embryol, Canakkale, Turkiye.
   [Ersavas, Cenk] Istanbul Arel Univ, Sch Med, Dept Gen Surg, Istanbul, Turkiye.
   [Gunal, Mehmet Y.] Alanya Alaaddin Keykubat Univ, Sch Med, Dept Physiol, Antalya, Turkiye.
C3 Marmara University; Istanbul Medipol University; Istanbul Medipol
   University; Canakkale Onsekiz Mart University; Istanbul Arel University;
   Alanya Alaaddin Keykubat University
RP Ozer, AY (通讯作者)，Marmara Univ, Hlth Sci Fac, Dept Physiotherapy & Rehabil, Istanbul, Turkiye.
EM aysel.yildiz@marmara.edu.tr
RI Yıldız Ozer, Aysel/IXW-8134-2023; Gunal, Mehmet/AAT-9806-2021; keskin,
   ilknur/A-6521-2018
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NR 47
TC 0
Z9 0
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2024
VL 33
SU 1
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IR8X8
UT WOS:001168161000001
DA 2026-07-24
ER
PT J
AU Gauntt, J
   Cox, VK
   Duffy, V
   Deitemyer, M
   Lloyd, E
   Bigelow, A
   McConnell, P
   Simsic, J
AF Gauntt, Jennifer
   Cox, Virginia Kathleen
   Duffy, Vicky
   Deitemyer, Matt
   Lloyd, Eric
   Bigelow, Amee
   McConnell, Patrick
   Simsic, Janet
TI Negative pressure therapy for ECMO cannula stabilization
SO PERFUSION-UK
LA English
DT Article
DE extracorporeal membrane oxygenation; negative pressure therapy;
   pediatrics
ID VACUUM-ASSISTED CLOSURE; WOUND MANAGEMENT; MEDIASTINITIS
AB Cannula stabilization for extracorporeal membrane oxygenation (ECMO) is important for patient mobilization and rehabilitation. Limitations to mobilization on ECMO include staff discomfort and cannula instability. We utilized the technique of negative pressure therapy for ECMO cannula stabilization to improve mobilization. Negative pressure therapy for ECMO cannula stabilization can be utilized safely for a variety of cannulation sites in any patient age from newborns to adults. This wound management strategy may facilitate patient mobilization and rehabilitation therapies in addition to extending cannula site duration.
C1 [Gauntt, Jennifer; Cox, Virginia Kathleen; Duffy, Vicky; Deitemyer, Matt; Lloyd, Eric; Bigelow, Amee; McConnell, Patrick; Simsic, Janet] Nationwide Childrens Hosp, Heart Ctr, 700 Childrens Dr, Columbus, OH 43205 USA.
C3 University System of Ohio; Ohio State University; Nationwide Childrens
   Hospital
RP Gauntt, J (通讯作者)，Nationwide Childrens Hosp, Heart Ctr, 700 Childrens Dr, Columbus, OH 43205 USA.
EM Jennifer.Gauntt@nationwidechildrens.org
RI ; Lloyd, Eric/E-3530-2011
OI Gauntt, Jennifer/0000-0003-4955-0938; Lloyd, Eric/0009-0001-0347-1719
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   de Leon JM, 2009, ADV SKIN WOUND CARE, V22, P122, DOI 10.1097/01.ASW.0000305452.79434.d9
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NR 14
TC 1
Z9 1
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0267-6591
EI 1477-111X
J9 PERFUSION-UK
JI Perfusion-UK
PD MAR
PY 2025
VL 40
IS 2
BP 343
EP 347
DI 10.1177/02676591241236640
EA FEB 2024
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Y3Y9E
UT WOS:001168759600001
PM 38400702
DA 2026-07-24
ER
PT J
AU Abu-Baker, A
   Tigaran, AE
   Peligrad, T
   Ion, DE
   Gheoca-Mutu, DE
   Avino, A
   Hariga, CS
   Moraru, OE
   Raducu, L
   Jecan, RC
AF Abu-Baker, Abdalah
   Tigaran, Andrada-Elena
   Peligrad, Teodora
   Ion, Daniela-Elena
   Gheoca-Mutu, Daniela-Elena
   Avino, Adelaida
   Hariga, Cristian-Sorin
   Moraru, Oriana Elena
   Raducu, Laura
   Jecan, Radu-Cristian
TI Exploring an Innovative Approach: Integrating Negative-Pressure Wound
   Therapy with Silver Nanoparticle Dressings in Skin Graft Procedures
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE chronic wounds; silver nanoparticles; negative wound pressure therapy;
   wound healing
ID C-REACTIVE PROTEIN; CONVENTIONAL THERAPY; FOOT; MECHANISM; EFFICACY;
   OUTCOMES; IMPACT; ULCER
AB Background: Skin grafting is a helpful instrument in a plastic surgeon's arsenal. Several types of dressings were designed to facilitate the process of graft integration. Negative-pressure wound therapy is a proven dressing method, enhancing graft survival through several mechanisms: aspiration of secretions, stimulation of neoangiogenesis, and promotion of an anti-inflammatory environment. Silver nanoparticle dressings also bring multiple benefits by bearing an antimicrobial effect and providing a humid medium, which are favorable for epithelialization. The combination of NPWT (negative-pressure wound therapy) with AgNPs (silver nanoparticles) has not been widely studied. Materials and methods: This study aimed to compare the outcomes of silver nanoparticle sheets with the combination of negative-pressure wound therapy and silver nanoparticle dressings. We conducted a comparative prospective study on 80 patients admitted to the Plastic Surgery Department of "Prof. Dr. Agrippa Ionescu" Emergency Clinical Hospital between 1st of January 2020 and 31st of December 2022. The study population was randomized to receive either silver nanoparticle dressings or negative-pressure wound therapy (NPWT) combined with silver nanoparticle dressings. Various parameters were monitored, including patient comorbidities and graft-related data such as defect etiology, graft integration, and graft size. Dressings were changed, and graft status was evaluated at 7, 10, and 14 days postoperatively. Additionally, baseline C-reactive protein (CRP) levels were measured before surgery and 7, 10, and 14 days postoperatively. Results: The study demonstrated an enhanced integration of skin grafts at all evaluation stages when employing NPWT combined with AgNPs, particularly evident 10 days post operation. Significant variations in graft integration were also observed based on factors such as diabetes, cardiovascular disease, graft size, or the origin of the grafted defect. Moreover, dynamic C-reactive protein monitoring showed a statistically significant decrease in CRP levels 10 days post operation among patients treated with NPWT in conjunction with silver dressing, consistent with the nearly complete integration of skin grafts at this evaluation threshold. Conclusion: Several factors influence the postoperative evolution of split-skin grafts. Postoperative dressings target local factors to enhance graft integration further. Our research demonstrated that the innovative combination of NPWT-assisted dressings, complemented by a silver nanoparticle sheet, resulted in improved benefits for graft integration and the alleviation of systemic inflammation.
C1 [Abu-Baker, Abdalah; Avino, Adelaida] Carol Davila Univ Med & Pharm, Doctoral Sch, Bucharest 010221, Romania.
   [Abu-Baker, Abdalah; Tigaran, Andrada-Elena; Peligrad, Teodora; Ion, Daniela-Elena; Gheoca-Mutu, Daniela-Elena; Avino, Adelaida; Raducu, Laura; Jecan, Radu-Cristian] Prof Dr Agrippa Ionescu Emergency Clin Hosp, Dept Plast Surg, Bucharest 011356, Romania.
   [Gheoca-Mutu, Daniela-Elena] Carol Davila Univ Med & Pharm, Discipline Anat, Bucharest 010221, Romania.
   [Hariga, Cristian-Sorin] Emergency Clin Hosp, Dept Plast Surg, Bucharest 014461, Romania.
   [Hariga, Cristian-Sorin; Raducu, Laura; Jecan, Radu-Cristian] Carol Davila Univ Med & Pharm, Discipline Plast Surg, Bucharest 010221, Romania.
   [Moraru, Oriana Elena] Carol Davila Univ Med & Pharm, Discipline Cardiovasc Surg, Bucharest 010221, Romania.
   [Moraru, Oriana Elena] Prof Dr Agrippa Ionescu Emergency Clin Hosp, Dept Vasc Surg, Bucharest 011356, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy;
   Carol Davila University of Medicine & Pharmacy
RP Gheoca-Mutu, DE; Raducu, L (通讯作者)，Prof Dr Agrippa Ionescu Emergency Clin Hosp, Dept Plast Surg, Bucharest 011356, Romania.; Gheoca-Mutu, DE (通讯作者)，Carol Davila Univ Med & Pharm, Discipline Anat, Bucharest 010221, Romania.; Raducu, L (通讯作者)，Carol Davila Univ Med & Pharm, Discipline Plast Surg, Bucharest 010221, Romania.
EM abdalah.abu-baker@drd.umfcd.ro; andrada-elena.tigaran@rez.umfcd.ro;
   teodora.peligrad@rez.umfcd.ro; daniela-elena.ion@rez.umfcd.ro;
   daniela-elena.mutu@umfcd.ro; adelaida.avino@drd.umfcd.ro;
   orianaelenamoraru@umfcd.ro; laura.raducu@umfcd.ro;
   cristian.jecan@umfcd.ro
RI Raducu, Laura/AAS-4867-2021; Tigaran, Andrada Elena/JGD-0035-2023;
   Avino, Adelaida/AEW-1705-2022; Jecan, Cristian Radu/ADU-3815-2022;
   Gheoca Mutu, Daniela Elena/AAQ-5197-2020; Abu-Baker,
   Abdalah/IWM-2121-2023
OI Jecan, Cristian Radu/0000-0002-4294-8911; Gheoca Mutu, Daniela
   Elena/0000-0002-8603-5807; Abu-Baker, Abdalah/0009-0009-7435-7196
FU University of Medicine and Pharmacy Carol Davila
FX No Statement Available
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NR 67
TC 13
Z9 18
U1 1
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD FEB
PY 2024
VL 14
IS 2
AR 206
DI 10.3390/jpm14020206
PG 16
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA IY8A8
UT WOS:001169980600001
PM 38392639
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Shyu, YC
   Huang, TS
   Chiu, HS
   Sumazin, P
   Lin, XY
   Liao, PC
   Liou, CC
   Hsu, FC
   Lin, JS
   Hsu, CC
   Hsu, PH
   Sun, CC
   Chen, CT
AF Shyu, Yu-Chiau
   Huang, Ting-Shuo
   Chiu, Hua-Sheng
   Sumazin, Pavel
   Lin, Xin-Yu
   Liao, Po-Cheng
   Liou, Cai-Cin
   Hsu, Fang-Chia
   Lin, Jyuan-Siou
   Hsu, Chih-Chin
   Hsu, Pang-Hung
   Sun, Chi-Chin
   Chen, Chien-Tzung
TI Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound
   Therapy in a Murine Model
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE negative pressure wound therapy (NPWT); dickkopf-related-protein1
   (DKK-1); hair follicle stem cells (HFSCs); epidermal cells; inflammatory
ID HAIR FOLLICLE; GROWTH-FACTORS; SKIN; DIFFERENTIATION; PROLIFERATION;
   EXPRESSION; DRESSINGS; MIGRATION; REPAIR
AB Negative Pressure Wound Therapy (NPWT) is a commonly employed clinical strategy for wound healing, yet its early-stage mechanisms remain poorly understood. To address this knowledge gap and overcome the limitations of human trials, we establish an NPWT C57BL/6JNarl mouse model to investigate the molecular mechanisms involved in NPWT. In this study, we investigate the intricate molecular mechanisms through which NPWT expedites wound healing. Our focus is on NPWT's modulation of inflammatory immune responses and the concurrent orchestration of multiple signal transduction pathways, resulting in shortened coagulation time and reduced inflammation. Notably, we observe a significant rise in dickkopf-related protein 1 (DKK-1) concentration during NPWT, promoting the differentiation of Hair Follicle Stem Cells (HFSCs) into epidermal cells, expediting wound closure. Under negative pressure, macrophages express and release DKK-1 cytokines, crucial for stimulating HFSC differentiation, as validated in animal experiments and in vitro studies. Our findings illuminate the inflammatory dynamics under NPWT, revealing potential signal transduction pathways. The proposed framework, involving early hemostasis, balanced inflammation, and macrophage-mediated DKK-1 induction, provides a novel perspective on enhancing wound healing during NPWT. Furthermore, these insights lay the groundwork for future pharmacological advancements in managing extensive wounds, opening avenues for targeted therapeutic interventions in wound care.
C1 [Shyu, Yu-Chiau; Lin, Xin-Yu; Liao, Po-Cheng; Liou, Cai-Cin; Hsu, Fang-Chia; Lin, Jyuan-Siou] Chang Gung Mem Hosp, Keelung Branch, Community Med Res Ctr, Keelung 204, Taiwan.
   [Shyu, Yu-Chiau] Chang Gung Univ Sci & Technol, Dept Nursing, Taoyuan 333, Taiwan.
   [Huang, Ting-Shuo] Jen Ai Hosp, Dept Gen Surg, Taichung 400, Taiwan.
   [Huang, Ting-Shuo] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan 333, Taiwan.
   [Chiu, Hua-Sheng; Sumazin, Pavel] Texas Childrens Hosp Canc Ctr, Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
   [Hsu, Chih-Chin] Chang Gung Univ, Sch Med, Dept Med, Taoyuan 333, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Keelung branch, Keelung 204, Taiwan.
   [Hsu, Pang-Hung] Natl Taiwan Ocean Univ, Dept Biosci & Biotechnol, Keelung 202, Taiwan.
   [Sun, Chi-Chin] Chang Gung Mem Hosp, Dept Ophthalmol, Keelung Branch, Keelung 204, Taiwan.
   [Chen, Chien-Tzung] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Linkou Branch, Taoyuan 333, Taiwan.
   [Chen, Chien-Tzung] Chang Gung Univ, Craniofacial Res Ctr, Taoyuan 333, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University of Science &
   Technology; Chang Gung University; Baylor College of Medicine; Chang
   Gung University; Chang Gung Memorial Hospital; National Taiwan Ocean
   University; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital;
   Chang Gung University
RP Shyu, YC (通讯作者)，Chang Gung Mem Hosp, Keelung Branch, Community Med Res Ctr, Keelung 204, Taiwan.; Shyu, YC (通讯作者)，Chang Gung Univ Sci & Technol, Dept Nursing, Taoyuan 333, Taiwan.; Chen, CT (通讯作者)，Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Linkou Branch, Taoyuan 333, Taiwan.; Chen, CT (通讯作者)，Chang Gung Univ, Craniofacial Res Ctr, Taoyuan 333, Taiwan.
EM yuchiaushyu@cgmh.org.tw; huangts1234@gmail.com; hchiu@bcm.edu;
   sumazin@bcm.edu; love20070810@gmail.com; henryshome@gmail.com;
   nice302a@gmail.com; jasonsyu0131@gmail.com; 0117siou@gmail.com;
   steele0618@gmail.com; panghung.ntou@gmail.com; chichinsun@gmail.com;
   ctchenap@cgmh.org.tw
RI ; Sumazin, Pavel/AAE-6607-2020; Huang, Ting-Shuo/ABD-3205-2021; Hsu,
   Pang-Hung/C-5587-2018; Chiu, Hua-Sheng/I-7150-2019
OI Shyu, Yu-Chiau/0000-0003-1747-2226; Sumazin, Pavel/0000-0002-1215-4977;
   Hsu, Chih-Chin/0000-0002-5558-3456; Hsu, Pang-Hung/0000-0001-6873-6434;
   Chiu, Hua-Sheng/0000-0002-0296-5653; Lin, Xin-Yu/0000-0003-3311-1754
FU Keelung Chang Gung Memorial Hospital
FX We thank Ching-Wen Yang, Yu-Han Kuo, Rou-Ling Cho and Chun-Ju Yang for
   technical communication.
CR Adler Elizabeth M., 2007, Sci. STKE, V2007, ptw176
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NR 38
TC 3
Z9 4
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2024
VL 25
IS 4
AR 2373
DI 10.3390/ijms25042373
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JH8K4
UT WOS:001172363500001
PM 38397048
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chew, DS
   Dayal, T
AF Chew, Derek S.
   Dayal, Taranvir
TI Economic Analysis of AbClo, a Novel Abdominal Fascia Closure Device, for
   Patients With an Open Abdomen Following Trauma or Acute Abdominal
   Surgery
SO SURGICAL INNOVATION
LA English
DT Article
DE acute care surgery; general surgery; the business of surgery; health
   economics; cost-benefit
ID MANAGEMENT; LAPAROTOMY; MORTALITY
AB Background Open Abdomen (OA) cases represent a significant surgical and resource challenge. AbClo is a novel non-invasive abdominal fascial closure device that engages lateral components of the abdominal wall muscles to support gradual approximation of the fascia and reduce the fascial gap. The study objective was to assess the economic implications of AbClo compared to negative pressure wound therapy (NPWT) alone on OA management.Methods We conducted a cost-minimization analysis using a decision tree comparing the use of the AbClo device to NPWT alone among patients with midline laparotomy for trauma or acute abdominal surgery who were ineligible for primary fascial closure. The time horizon was limited to the length of the inpatient hospital stay, and costs were considered from the perspective of the US Medicare payer. Clinical effectiveness data for AbClo was obtained from a randomized clinical trial. Cost data was obtained from the published literature. Probabilistic and deterministic sensitivity analyses were performed. The primary outcome was incremental cost.Results The mean cumulative costs per patient were $76 582 for those treated with NPWT alone and $70,582 for those in the group treated with the AbClo device. Compared to NPWT alone, AbClo was associated with lower incremental costs of -$6012 (95% CI -$19 449 to +$1996). The probability that AbClo was cost-savings compared to NPWT alone was 94%.Conclusions The use of AbClo is an economically attractive strategy for management of OA in in patients with midline laparotomy for trauma or acute abdominal surgery who were ineligible for primary fascial closure.
C1 [Chew, Derek S.] Univ Calgary, O Brien Inst Publ Hlth, Dept Med, Calgary, AB, Canada.
   [Chew, Derek S.] Univ Calgary, Libin Cardiovasc Inst, Dept Cardiac Sci, Calgary, AB, Canada.
   [Dayal, Taranvir] InventoRR MD Inc, Toronto, ON, Canada.
   [Chew, Derek S.] Cardiac Sci & Med GE55, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada.
C3 University of Calgary; University of Calgary; Libin Cardiovascular
   Institute Of Alberta
RP Chew, DS (通讯作者)，Cardiac Sci & Med GE55, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada.
EM dchew@ucalgary.ca
FU InventoRR MD Inc.
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Financial
   support of this study was provided by InventoRR MD Inc.
CR [Anonymous], Acute Inpatient Prospective Payment System
   Betancourt AS, 2020, ANN MED SURG, V56, P11, DOI 10.1016/j.amsu.2020.06.007
   Carney MJ, 2017, AM J SURG, V214, P287, DOI 10.1016/j.amjsurg.2017.01.001
   Chabot Elizabeth, 2017, Trauma Surg Acute Care Open, V2, pe000063, DOI [10.1136/tsaco-2016-000063, 10.1136/tsaco-2016-000063]
   Chen Y, 2014, GASTROENT RES PRACT, V2014, DOI 10.1155/2014/784056
   Childers CP, 2018, JAMA SURG, V153, DOI 10.1001/jamasurg.2017.6233
   Cothren CC, 2006, AM J SURG, V192, P238, DOI 10.1016/j.amjsurg.2006.04.010
   DuBose JJ, 2013, J TRAUMA ACUTE CARE, V74, P113, DOI 10.1097/TA.0b013e31827891ce
   Fantus RJ, 2006, AM J SURG, V192, P243, DOI 10.1016/j.amjsurg.2005.11.013
   Fernández LG, 2016, INT WOUND J, V13, P25, DOI 10.1111/iwj.12655
   Harvin JA, 2017, J TRAUMA ACUTE CARE, V83, P464, DOI 10.1097/TA.0000000000001619
   Hu P, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0204-3
   Husereau Don, 2013, Cost Eff Resour Alloc, V11, P6, DOI 10.1186/1478-7547-11-6
   Rasilainen S, 2020, J TRAUMA ACUTE CARE, V89, P1136, DOI 10.1097/TA.0000000000002889
   Reynolds D, 2013, J GASTROINTEST SURG, V17, P159, DOI 10.1007/s11605-012-1999-y
   Rezende-Neto JB, 2020, TRAUMA SURG ACUTE CA, V5, DOI 10.1136/tsaco-2020-000523
   Seternes A, 2016, CRIT CARE, V20, DOI 10.1186/s13054-016-1337-y
   U.S. Department of Labor: Bureau of Labor Statistics, 2020, CONSUMER PRICE INDEX
NR 18
TC 1
Z9 1
U1 1
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD JUN
PY 2024
VL 31
IS 3
BP 233
EP 239
DI 10.1177/15533506241236745
EA FEB 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OP4Q6
UT WOS:001173369600001
PM 38411561
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Afzal, H
   Dawson, E
   Fonseca, R
   Canas, M
   Diaz, L
   De Filippis, A
   Bochicchio, KM
   Bochicchio, GV
AF Afzal, Hussain
   Dawson, Erin
   Fonseca, Ricardo
   Canas, Melissa
   Diaz, Leonardo
   De Filippis, Alejandro
   Bochicchio, Kelly M.
   Bochicchio, Grant V.
TI Does Negative Pressure Wound Therapy Impact the Outcome for Patients
   With Necrotizing Soft Tissue Infection Infected With Anaerobic Bacteria?
SO SURGICAL INFECTIONS
LA English
DT Article
DE anaerobic bacteria; clinical outcomes; necrotizing soft tissue
   infection; negative pressure wound therapy; re-admission
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Background: A notable improvement in the treatment of necrotizing soft tissue infections (NSTIs) is the development of negative pressure wound therapy (NPWT). Clinicians are still debating whether NPWT is as successful as conventional wet-to-dry dressings at removing bacteria. Recent research has revealed potential oxygen deprivation effects of NPWT in underlying wound tissues, although clinical trials regarding the effects of reduced oxygen on anaerobic bacterial soft tissue infections remain noticeably lacking.Hypothesis: We hypothesized that NPWT-treated patients with NSTIs who were solely infected by anaerobic bacteria would have worse outcomes than those who were infected with other bacterial species.Patients and Methods: Our study included a retrospective examination of the 2008-2022 period of our Acute and Critical Care Surgery database. Patients who had been identified as having necrotizing fasciitis, Fournier gangrene, or gas gangrene and who had their conditions verified by positive wound cultures acquired during the initial debridement and subsequently received NPWT made up the study cohort. Comorbidities, surgical techniques, and clinical results were all covered by the data. Based on their wound infections, patients were divided into two groups: those with exclusively anaerobic NSTIs and those with different bacterial groups (such as polymicrobial and aerobic). Multiple regression, chi 2 analysis, and analysis of variance (ANOVA) were among the analytical methods used.Results: One hundred twelve patients with NSTI who had received NPWT comprised the study cohort. Sixteen of these patients (14.3%) had NSTIs that were exclusively anaerobic, whereas the remaining 96 (85.7%) had NSTIs that were mixed aerobic, facultative, or polymicrobial. Between the two groups, there was no difference in the initial wound size. Patients with anaerobic NSTI who underwent NPWT showed a statistically significant increase in the number of debridements (3 [interquartile range {IQR},1-9] vs. 2 [IQR, 1-4]; p = 0.012) and an increased 100-day re-admission rate (37.5% vs. 12.5%; p = 0.012) when compared with patients with non-anaerobic NSTI. The 100-day re-admission rate increased three-fold in NPWT-treated anaerobic NSTIs, according to a logistic regression analysis (odds ratio [OR], 3.63; 95% confidence interval [CI], 1.06-12.44; p = 0.04).Conclusions: In contrast to patients with other bacterial strains, our data show that patients with NSTI treated with NPWT who only have anaerobic bacterial infections have a larger number of debridements and are much more likely to require re-admission within 100 days. We call for additional prospective studies to be conducted to identify additional risk factors and consider alternate treatment options for individuals with exclusively anaerobic NSTIs in light of these findings.
C1 [Afzal, Hussain; Fonseca, Ricardo; Canas, Melissa; Diaz, Leonardo; Bochicchio, Kelly M.; Bochicchio, Grant V.] Washington Univ, Sch Med, Acute & Crit Care Surg, 660 South Euclid Ave,Campus Box 8109, St Louis, MO 63110 USA.
   [Dawson, Erin] Trauma & Surg Crit Care, Penn Med, Philadelphia, PA USA.
   [De Filippis, Alejandro] Gen Surg, Dartmouth Hlth, Lebanon, NH USA.
C3 Washington University (WUSTL); University of Pennsylvania; Pennsylvania
   Medicine
RP Afzal, H (通讯作者)，Washington Univ, Sch Med, Acute & Crit Care Surg, 660 South Euclid Ave,Campus Box 8109, St Louis, MO 63110 USA.
EM hussain.afzal@wustl.edu
RI ; Fonseca, Ricardo/JCO-8533-2023
OI Díaz Agurto, Leonardo/0000-0002-4261-2000; Fonseca,
   Ricardo/0000-0003-2363-1270; Dawson, Erin/0000-0003-0702-4032
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   Yusuf E, 2013, WOUND REPAIR REGEN, V21, P677, DOI 10.1111/wrr.12088
NR 21
TC 9
Z9 13
U1 1
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD MAR 1
PY 2024
VL 25
IS 2
BP 147
EP 154
DI 10.1089/sur.2023.300
EA FEB 2024
PG 8
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA KJ2R9
UT WOS:001173727800002
PM 38381953
DA 2026-07-24
ER
PT J
AU Garnica, DGG
   Chaves, CER
   Barco-Castillo, C
   Gutierrez, JA
   Falla, A
AF Garnica, David Guillermo Gomez
   Chaves, Carlos Eduardo Rey
   Barco-Castillo, Catalina
   Gutierrez, Jorge Andres
   Falla, Andres
TI Negative Pressure Wound Therapy After Intestinal Anastomosis: A Risk
   Factor Analysis for Dehiscence
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Anastomotic dehiscence; Intestinal anastomosis; Negative pressure wound
   therapy; Open abdomen; Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; SURGICAL COMPLICATIONS; SECONDARY
   PERITONITIS; CLASSIFICATION; MANAGEMENT
AB Introduction: Negative pressure wound therapy (NPWT) is part of the temporary abdominal closure in the treatment of patients with traumatic, inflammatory, or vascular disease. However, the use of NPWT when performing an intestinal anastomosis has been controversial. This study aimed to describe the patients managed with NPWT therapy and identify the risk factors for anastomotic dehiscence when intestinal anastomosis was performed. Methods: A single -center cohort study with prospectively collected databases was performed. Patients who required NPWT therapy from January 2014 to December 2018 were included. Patients were stratified according to the performance of intestinal anastomosis and according to the presence of dehiscence. Bivariate and multivariate analyses were performed for anastomotic dehiscence and mortality. Results: A total of 97 patients were included. Median age was 52 y old [interquartile range 24.5-70]. Male patients corresponded to 75.6% (n = 34) of the population. Delayed fascial closure was performed in 80% (n = 36). The risk of anastomotic dehiscence was higher in females (odds ratio (OR) 11.52 [confidence interval (CI) 1.29-97.85], P = 0.030), delayed fascial closure (OR 18.18 [CI 2.02-163.5], P = 0.010) and use of vasopressors (OR 12.04 [CI 1.22118.47], P = 0.033). NPWT pressures >110 mmHg were evidenced in the dehiscence group with statistically significant value (OR 1.2 [0.99-2.26] p 0.04) Conclusions: There is still controversy in the use of NPWT when performing intestinal anastomosis. According to our data, the risk of dehiscence is higher in females, delayed fascial closure, use of vasopressors, and NPWT pressures >110 MMHG. \ (c) 2024 The Author(s). Published by Elsevier Inc.
C1 [Garnica, David Guillermo Gomez; Gutierrez, Jorge Andres; Falla, Andres] Hosp Militar Cent, Dept Gen Surg, Bogota, DC, Colombia.
   [Garnica, David Guillermo Gomez; Barco-Castillo, Catalina; Gutierrez, Jorge Andres; Falla, Andres] Univ Militar Nueva Granada, Sch Med, Bogota 10180, DC, Colombia.
   [Garnica, David Guillermo Gomez; Gutierrez, Jorge Andres] Pontificia Univ Javeriana, Hosp Univ San Ignacio, Fac Med, Cirugia Gen, Bogota, Colombia.
   [Chaves, Carlos Eduardo Rey] Pontificia Univ Javeriana, Fac Med, Estudiante Posgrad Cirugia Gen, Bogota, Colombia.
   [Barco-Castillo, Catalina] Hosp Militar Cent, Dept Urol, Bogota, DC, Colombia.
   [Chaves, Carlos Eduardo Rey] Pontificia Univ Javeriana, Fac Med, Estudiante Posgrad Cirugia Gen, Bogota 111711, Colombia.
C3 Universidad Militar Nueva Granada; Hospital Universitario San Ignacio;
   Pontificia Universidad Javeriana; Pontificia Universidad Javeriana;
   Pontificia Universidad Javeriana
RP Chaves, CER (通讯作者)，Pontificia Univ Javeriana, Fac Med, Estudiante Posgrad Cirugia Gen, Bogota 111711, Colombia.
EM carlosrey991@gmail.com
RI /A-5153-2019
OI Rey Chaves, Carlos Eduardo/0000-0001-6888-5595
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NR 21
TC 5
Z9 5
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD APR
PY 2024
VL 296
BP 223
EP 229
DI 10.1016/j.jss.2024.01.003
EA JAN 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JT6N0
UT WOS:001175453800001
PM 38286101
OA hybrid
DA 2026-07-24
ER
PT J
AU Allen, D
   Mann, S
   Robinson, T
   Schmidt, M
   Kieswetter, K
AF Allen, Diwi
   Mann, Samantha
   Robinson, Timothy
   Schmidt, Marisa
   Kieswetter, Kristine
TI Preclinical Assessments of a Novel Peel and Place Extended-Wear
   Negative-Pressure Wound Therapy Dressing for up to 35 Days in a Porcine
   Model
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; NPWT; negative pressure therapy; NPT;
   reticulated open cell foam; ROCF; wounds; wound healing; porcine model;
   swine; long-term wear dressing; extended wear dressing
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; PROGRESSION; MECHANISM
AB Objective: While the use of negative pressure wound therapy (NPWT) with reticulated open cell foam (ROCF) is well established, the characteristics of ROCF do not allow for extended-wear use. There is the potential for dressing tissue ingrowth if left in place for greater than the recommended 2-3 days. An easy to use, novel peel and place dressing has been designed for extended wear with the wound management advantages of ROCF while alleviating the challenges of tissue ingrowth.Approach: Paraspinal, full-thickness or deep muscle excisional wounds were created in 11 and 2 swine, respectively, dressings applied with continuous negative pressure at -125 mmHg, and dressings changed weekly. Full-thickness excisional wounds were treated for 13 days and deep muscle wounds for 35 days. Wound dimensions were assessed. Granulation tissue thickness and re-epithelialization were measured via digital morphometry. Tissue quality, fibrinous material prevalence, and dressing removal peel force were analyzed.Results: The peel and place dressing substantially reduces dressing tissue ingrowth, is easy to remove with markedly low dressing peel force and promotes more granulation tissue at day 13 than ROCF with an interface layer. The extended-wear peel and place dressing, when applied to deep muscle wounds with weekly dressing changes, was applied for a total of 35 days. Successful wound closure was evident without any negative impact on wound healing.Innovation: This study assessed the wound management capabilities of an extended-wear peel and place NPWT dressing used until wound closure.Conclusion: The peel and place dressing is a suitable extended-wear NPWT dressing.
C1 [Allen, Diwi; Mann, Samantha; Robinson, Timothy; Schmidt, Marisa; Kieswetter, Kristine] 3M Hlth Care, Med Solut Div, San Antonio, TX 78249 USA.
C3 3M
RP Allen, D (通讯作者)，3M Hlth Care, Med Solut Div, San Antonio, TX 78249 USA.
EM dlallen@solventum.com
FU The 3M Health Care
FX Financial support was provided by 3M Health Care.
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NR 29
TC 3
Z9 4
U1 1
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUN 1
PY 2024
VL 13
IS 6
BP 291
EP 307
DI 10.1089/wound.2023.0096
EA FEB 2024
PG 17
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA UE1N8
UT WOS:001176090600001
PM 38205649
OA hybrid
DA 2026-07-24
ER
PT J
AU De Marco, R
   Nasto, LA
   Strangio, A
   Piatelli, G
   Pavanello, M
AF De Marco, Raffaele
   Nasto, Luigi Aurelio
   Strangio, Antonio
   Piatelli, Gianluca
   Pavanello, Marco
TI Surgical limits, pitfalls, and potential solutions in kyphectomy in
   myelomeningocele: three cases and systematic review of the literature
SO CHILDS NERVOUS SYSTEM
LA English
DT Review
DE Kyphosis; Myelomeningocele; Kyphectomy; Spinal deformity; NPWT (negative
   pressure wound therapy)
ID SPINAL-CORD TRANSECTION; LONG-TERM; CONGENITAL KYPHOSIS; LUMBAR
   KYPHOSIS; NATURAL-HISTORY; LUQUE INSTRUMENTATION; KYPHOTIC DEFORMITY;
   TISSUE EXPANSION; CHILDREN; FIXATION
AB ObjectivesTo describe surgical treatment of 3 cases of severe and progressive thoracolumbar kyphosis in myelomeningocele and provide a systematic review of the available literature on the topic.MethodsMedical records and pre- and post-operative imaging of 3 patients with thoracolumbar kyphosis and myelomeningocele were reviewed. A database search was performed for all manuscripts published on kyphectomy and/or surgical treatment of kyphosis in myelomeningocele. Patients' information, preoperative kyphosis angle, type of surgery, levels of surgery degrees of correction after surgery and at follow-up, and complications were reviewed for the included studies.ResultsThree cases underwent posterior vertebral column resection (pVCR) of 2-4 segments at the apex of the kyphosis (kyphectomy). Long instrumentation was performed with all pedicle screws constructed from the thoracic spine to the pelvis using iliac screws. According to literature review, a total of 586 children were treated for vertebral kyphosis related to myelomeningocele. At least one vertebra was excised to gain some degree of correction of the deformity. Different types of instrumentation were used over time and none of them demonstrated to be superior over the other.ConclusionSurgical treatment of progressive kyphosis in myelomeningocele has evolved over the years incorporating all major advances in spinal instrumentation techniques. Certainly, the best results in terms of preservation of correction after surgery and less revision rates were obtained with long construct and screws. However, complication rate remains high with skin problems being the most common complication. The use of low-profile instrumentation remains critical for treatment of these patients.
C1 [De Marco, Raffaele; Strangio, Antonio] Univ Turin, Dept Neurosci R Levi Montalcini, Turin, Italy.
   [Nasto, Luigi Aurelio] Univ Luigi Vanvitelli, Azienda Osped, Naples, Italy.
   [Piatelli, Gianluca; Pavanello, Marco] IRCCS Ist G Gaslini, Dept Neurosurg, Via G Gaslini 5, I-16148 Genoa, Italy.
C3 University of Turin; Universita della Campania Vanvitelli; University of
   Genoa; IRCCS Istituto Giannina Gaslini
RP De Marco, R (通讯作者)，Univ Turin, Dept Neurosci R Levi Montalcini, Turin, Italy.
EM raffaele.demarco@unito.it
RI Marco, Pavanello/K-2859-2019; Nasto, Luigi/AAA-8197-2020; De Marco,
   Raffaele/MHR-8528-2025; Piatelli, Gianluca/ABG-1045-2020
OI De Marco, Raffaele/0000-0001-5187-4689; 
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NR 70
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0256-7040
EI 1433-0350
J9 CHILD NERV SYST
JI Childs Nerv. Syst.
PD MAY
PY 2024
VL 40
IS 5
BP 1541
EP 1569
DI 10.1007/s00381-024-06341-8
EA MAR 2024
PG 29
WC Clinical Neurology; Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pediatrics; Surgery
GA OA5X9
UT WOS:001177346500001
PM 38459148
DA 2026-07-24
ER
PT J
AU Lu, YP
   Zhao, DJ
   Cao, GQ
   Yin, SY
   Liu, CY
   Song, R
   Ma, JX
   Sun, R
   Wu, ZJ
   Liu, J
   Wu, P
   Wang, YB
AF Lu, Yongpan
   Zhao, Dejie
   Cao, Guoqi
   Yin, Siyuan
   Liu, Chunyan
   Song, Ru
   Ma, Jiaxu
   Sun, Rui
   Wu, Zhenjie
   Liu, Jian
   Wu, Peng
   Wang, Yibing
TI Research progress on and molecular mechanism of vacuum sealing drainage
   in the treatment of diabetic foot ulcers
SO FRONTIERS IN SURGERY
LA English
DT Review
DE vacuum sealing drainage; trauma repair; diabetic foot ulcers; molecular
   mechanism; clinical treatment
ID PRESSURE WOUND THERAPY; NF-KAPPA-B; ASSISTED CLOSURE THERAPY;
   NEGATIVE-PRESSURE; CELL-DEATH; EXTRACELLULAR-MATRIX; WNT/BETA-CATENIN;
   UP-REGULATION; SKIN-GRAFTS; TISSUE
AB Diabetic foot ulcers (DFUs) are common chronic wounds and a common complication of diabetes. The foot is the main site of diabetic ulcers, which involve small and medium-sized arteries, peripheral nerves, and microcirculation, among others. DFUs are prone to coinfections and affect many diabetic patients. In recent years, interdisciplinary research combining medicine and material science has been increasing and has achieved significant clinical therapeutic effects, and the application of vacuum sealing drainage (VSD) in the treatment of DFUs is a typical representative of this progress, but the mechanism of action remains unclear. In this review, we integrated bioinformatics and literature and found that ferroptosis is an important signaling pathway through which VSD promotes the healing of DFUs and that System Xc-GSH-GPX4 and NAD(P)H-CoQ10-FSP1 are important axes in this signaling pathway, and we speculate that VSD is most likely to inhibit ferroptosis to promote DFU healing through the above axes. In addition, we found that some classical pathways, such as the TNF, NF-kappa B, and Wnt/beta-catenin pathways, are also involved in the VSD-mediated promotion of DFU healing. We also compiled and reviewed the progress from clinical studies on VSD, and this information provides a reference for the study of VSD in the treatment of DFUs.
C1 [Lu, Yongpan] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China.
   [Lu, Yongpan; Cao, Guoqi; Yin, Siyuan; Liu, Chunyan; Song, Ru; Ma, Jiaxu; Sun, Rui; Wu, Zhenjie; Liu, Jian; Wu, Peng; Wang, Yibing] Shandong First Med Univ & Shandong Prov Qianfoshan, Affiliated Hosp 1, Jinan Clin Res Ctr Tissue Engn Skin Regenerat & Wo, Jinan, Peoples R China.
   [Zhao, Dejie] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Vasc Surg, Jinan, Peoples R China.
   [Cao, Guoqi; Ma, Jiaxu; Sun, Rui; Wu, Zhenjie] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Plast Surg, Jinan, Peoples R China.
   [Yin, Siyuan; Liu, Chunyan; Song, Ru; Liu, Jian; Wu, Peng; Wang, Yibing] Shandong First Med Univ & Shandong Prov Qianfoshan, Dept Plast Surg, Affiliated Hosp 1, Jinan, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University; Shandong First
   Medical University & Shandong Academy of Medical Sciences
RP Wang, YB (通讯作者)，Shandong First Med Univ & Shandong Prov Qianfoshan, Affiliated Hosp 1, Jinan Clin Res Ctr Tissue Engn Skin Regenerat & Wo, Jinan, Peoples R China.; Wang, YB (通讯作者)，Shandong First Med Univ & Shandong Prov Qianfoshan, Dept Plast Surg, Affiliated Hosp 1, Jinan, Peoples R China.
EM ybwang@sdfmu.edu.cn
FU National Natural Science Foundation of China
FX The authors acknowledge Cell Signaling and BioRender and thank Cindy for
   the ideas used to draw the line graphs.
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NR 152
TC 5
Z9 6
U1 3
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD FEB 23
PY 2024
VL 11
AR 1265360
DI 10.3389/fsurg.2024.1265360
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KC0F1
UT WOS:001177636500001
PM 38464666
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zheng, ZL
   Brown, T
   Adams, F
   Roberson, R
   Ma, R
   Wilson, JA
   Morykwas, M
   Argenta, L
AF Zheng, Zhenlin
   Brown, Theodore
   Adams, Farren
   Roberson, Rebecca
   Ma, Rong
   Wilson, John A.
   Morykwas, Michael
   Argenta, Louis
TI Novel treatment of intracerebral hemorrhage with mechanical tissue
   resuscitation
SO JOURNAL OF NEUROSURGERY
LA English
DT Article
DE intracerebral hemorrhage; subatmospheric pressure; mechanical tissue
   resuscitation; vascular disorders
ID VACUUM-ASSISTED CLOSURE; SUBSEQUENT FIBRINOLYTIC THERAPY; STEREOTACTIC
   HEMATOMA PUNCTURE; PLASMINOGEN-ACTIVATOR; DECOMPRESSIVE CRANIECTOMY;
   ASPIRATION; CLOT; EVACUATION; REDUCTION; INJURY
AB OBJECTIVE The previous laboratory and clinical experience of the authors had demonstrated that application of controlled subatmospheric pressure directly to injured soft tissue can result in increased survival of compromised tissues. Mechanical tissue resuscitation (MTR) is a new concept evolving from these discoveries. The authors' recent studies have demonstrated that traumatic brain injury tissue can also be salvaged. The aim of this study was to examine the effects of MTR application to injuries from intracerebral hemorrhages (ICHs) in a swine model. METHODS The ICHs in swine were simulated by infusion of autologous artery blood into the right frontal lobe. A specially designed silicone manifold device was introduced directly into the hematoma. Continuous negative pressure at -50 mm Hg was applied through this device. T2- and T2*-weighted MRI, histological H&E staining, and immunostaining were examined. RESULTS After 1 week of treatment, MTR significantly decreased gross hematoma volume by more than 60%, from 472.62 +/- 230.19 mm(3) in the nontreated group to 171.25 +/- 75.38 mm(3) in the MTR-treated group (p < 0.05). Total hypointense volumes measured on T2*-weighted MR images decreased from 791.99 +/- 360.47 mm(3) in the nontreated group to 371.16 +/- 105.75 mm(3) in the MTR-treated group (p < 0.05). The hyperintense area on the T2-weighted MR image decreased significantly from 2656.23 +/- 426.26 mm(3) in the nontreated group to 1816.66 +/- 525.26 mm(3) in the MTR-treated group (p < 0.05). When ICHs were treated with MTR for 2 weeks, the gross hematomas were reduced by 94%, from 112.23 +/- 66.21 mm(3) in the nontreated group to 6.12 +/- 10.99 mm(3) in the MTR-treated group (p = 0.003). MTR significantly decreased the total necrotic tissue volume in H&E staining from 120.42 +/- 48.35 mm(3) in the nontreated group to 60.94 +/- 38.99 mm(3) in the MTR-treated group (p < 0.05). The total hypointense volumes on T2*-weighted MR images were significantly reduced, from 385.54 +/- 93.85 mm(3) in the nontreated group to 220.54 +/- 104.28 mm(3) in the MTR-treated group (p < 0.05), while their mean T2 hyperintense volume decreased significantly from 2192.83 +/- 728.27 mm(3) in the nontreated group to 1366.97 +/- 463.36 mm(3) in the MTR-treated group (p < 0.05). Histology revealed that the capillary diameter in the reactive tissue rim adjacent to the hematoma increased in both the 1- and 2-week MTR-treated groups. Both von Willebrand factor and CD31 signals were detectable in endothelial cells within the hematoma cavity of both MTR-treated groups. CONCLUSIONS This study demonstrates that local continuous application of controlled subatmospheric pressure to an ICH can safely remove more than half of a clot in 1 week and more than 90% in 2 weeks.
C1 [Zheng, Zhenlin; Brown, Theodore; Adams, Farren; Roberson, Rebecca; Ma, Rong; Morykwas, Michael; Argenta, Louis] Wake Forest Univ Hlth Sci, Dept Plast & Reconstruct Surg, Winston Salem, NC 27109 USA.
   [Wilson, John A.] Wake Forest Univ Hlth Sci, Dept Neurosurg, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest University School of Medicine; Wake
   Forest University; Wake Forest University School of Medicine
RP Morykwas, M (通讯作者)，Wake Forest Univ Hlth Sci, Dept Plast & Reconstruct Surg, Winston Salem, NC 27109 USA.
EM mmorykwa@wakehealth.edu
OI Morykwas, Michael/0009-0001-5547-5172
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NR 38
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 0022-3085
EI 1933-0693
J9 J NEUROSURG
JI J. Neurosurg.
PD JAN
PY 2024
VL 140
IS 1
BP 153
EP 163
DI 10.3171/2023.5.JNS2315
PG 11
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA KC0M1
UT WOS:001177643500001
PM 37439483
DA 2026-07-24
ER
PT J
AU Shang, W
   Liu, PC
   Cheng, X
   Wang, X
   Yu, Y
AF Shang, W.
   Liu, Peichao
   Cheng, X.
   Wang, X.
   Yu, Y.
TI Clinical Efficacy of Antibiotic Bone Cement and Lateral Bone
   Repositioning for Severe Diabetic Foot and its Impact on Wound Healing
   Rate
SO INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Diabetic foot; antibiotic bone cement; lateral bone repositioning; lower
   limb function; dorsalis; pedis artery
AB To evaluate the clinical efficacy of antibiotic bone cement plus lateral bone repositioning for severe diabetic foot and its impact on wound healing rate. Sixty patients with hemodialysis anemia admitted to the endocrinology department of our hospital from July 2020 to July 2021 were included and randomly assigned to receive antibiotic bone cement plus lateral bone repositioning (observation group) or vacuum sealing drainage (control group). Outcome measures included skin temperature of the affected limb, ankle- brachial index, sensory threshold, foot wound healing, dorsalis pedis artery hemodynamics, lower limb function and clinical efficacy. Antibiotic bone cement plus lateral bone repositioning resulted in significantly higher treatment efficiency and transcutaneous partial pressure of oxygen, smaller wound and lower trauma pH vs. vacuum sealing drainage, suggesting that antibiotic bone cement plus lateral bone repositioning contributes to potentiating the treatment efficacy and reducing the foot ulcer trauma, thereby facilitating rapid recovery. Patients given antibiotic bone cement plus lateral bone repositioning had larger vascular internal diameter and blood flow and better sensory conduction velocity of the common peroneal nerve and the motor conduction velocity of the tibial nerve vs. those given vacuum sealing drainage, indicating its vascular and neurological benefits. Antibiotic bone cement plus lateral bone repositioning enhances the treatment efficiency, boosts trauma healing and promotes postoperative functional recovery of patients.
C1 [Shang, W.; Liu, Peichao; Cheng, X.; Wang, X.; Yu, Y.] Hubei Univ Med, Renmin Hosp, Dept Orthoped, Shiyan 442000, Hubei, Peoples R China.
C3 Hubei University of Medicine
RP Wang, X (通讯作者)，Hubei Univ Med, Renmin Hosp, Dept Orthoped, Shiyan 442000, Hubei, Peoples R China.
EM taodao753547@163.com
CR Anaya-Isaza A, 2022, BIOCYBERN BIOMED ENG, V42, P437, DOI 10.1016/j.bbe.2022.03.001
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NR 27
TC 0
Z9 0
U1 1
U2 2
PU INDIAN PHARMACEUTICAL ASSOC
PI MUMBAI
PA KALINA, SANTA CRUZ EAST, MUMBAI, 00000, INDIA
SN 0250-474X
EI 1998-3743
J9 INDIAN J PHARM SCI
JI Indian J. Pharm. Sci.
PY 2023
VL 85
SI 5
BP 262
EP 269
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KE0S4
UT WOS:001178170400037
DA 2026-07-24
ER
PT J
AU Alawi, SA
   Taqatqeh, F
   Matschke, J
   Bota, O
   Dragu, A
AF Alawi, Seyed Arash
   Taqatqeh, Feras
   Matschke, Jan
   Bota, Olimpiu
   Dragu, Adrian
TI Use of a collagen-elastin matrix with split-thickness skin graft for
   defect coverage in complex wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE collagen-elastin matrix; complicated wound; wound; wound care; wound
   dressing; wound healing; wound therapy; negative pressure wound therapy;
   soft tissue coverage; split-thickness skin graft
ID RECONSTRUCTIVE LADDER; FLAP
AB Objective: Severe soft tissue damage with destruction of the dermis requires plastic reconstructive treatment. For multimorbid patients or patients unable to undergo major reconstructive surgery, use of dermal substitutes, such as a collagen-elastin matrix (CEM) with a splitthickness skin graft (STSG), instead of local or free flap surgery, may be a valid and easy treatment option. We aimed to investigate and compare the outcomes and rate of successful defect reconstruction using CEM plus STSG, using either a one-step approach (simultaneous CEM and STSG) or a two-step approach (CEM and negative wound pressure therapy (NPWT), with secondary STSG transplantation). Method: A single-centre, retrospective follow-up study of patients who had received CEM was conducted. Wounds had been treated with an STSG transplantation covering a CEM (MatriDerm, MedSkin Solutions Dr. Suwelack AG, Germany). Previous attempts at wound closure with conventional methods had failed in the selected patient population, which would usually have resulted in flap surgery. Results: Overall, 46 patients were included (mean age 60.9 +/- 20.0 years), with a total of 49 wound sites. We analysed 38 patients with wounds that did not require flap coverage; 18 patients received the one-step approach and 20 patients received the two-step approach. The mean follow-up in these patients was 22 +/- 11.5 months, and one patient was lost to follow-up. Overall, 29 (78.4%) wounds remained comorbidities, such as diabetes, alcohol misuse and smoking. Using the one-step approach, long-term defect coverage was achieved in 13 (76.5%) wounds and 16 (80.0%) wounds were closed using the two-step approach. However, there was no statistically significant differences between the one- or two-step approaches regarding the rate of development of a wound healing disorder. Conclusion: Wound closure was achieved in 38 complex wounds using CEM plus STSG, while 11 wounds needed secondary flap coverage. In the flap-free wounds, there were no statistically significant differences between the one-step versus two-step approach. Using a simple defect reconstruction algorithm, we successfully used CEM plus STSG to treat complex wounds. Declaration of interest: Editorial assistance was provided by MedSkin Solutions Dr. Suwelack AG, Germany. The company had no influence on the content of the paper. The authors have no other conflicts of interest to declare
C1 [Alawi, Seyed Arash; Taqatqeh, Feras; Dragu, Adrian] Tech Univ Dresden, Univ Ctr Orthoped Trauma & Plast Surg, Univ Hosp Carl Gustav Carus, Dept Plast & Hand Surg, Dresden, Germany.
   [Matschke, Jan] Tech Univ Dresden, Dept Maxillofacial Surg, Univ Hosp Carl Gustav Carus, Dresden, Germany.
   [Bota, Olimpiu] Iuliu Hatieganu Univ Med, Emergency Cty Hosp Cluj Napoca, Dept Plast Surg, Surg Clin 1, Cluj Napoca, Romania.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   Iuliu Hatieganu University of Medicine & Pharmacy
RP Alawi, SA (通讯作者)，Tech Univ Dresden, Univ Ctr Orthoped Trauma & Plast Surg, Univ Hosp Carl Gustav Carus, Dept Plast & Hand Surg, Dresden, Germany.
EM seyed-arash.alawi@uniklinikum-dresden.de
RI Dragu, Adrian/AAH-3506-2019; Alawi, Seyed Arash/AFK-2242-2022; Bota,
   Olimpiu/AAN-4292-2021
CR Chua AWC, 2016, BURNS TRAUMA, V4, DOI 10.1186/s41038-016-0027-y
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NR 20
TC 6
Z9 6
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2024
VL 33
IS 1
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA KG5F5
UT WOS:001178811300004
DA 2026-07-24
ER
PT J
AU Afzal, H
   Dawson, E
   Fonseca, R
   Canas, M
   Diaz, L
   Filippis, AD
   Mazuski, J
   Bochicchio, KM
   Bochicchio, GV
AF Afzal, Hussain
   Dawson, Erin
   Fonseca, Ricardo
   Canas, Melissa
   Diaz, Leonardo
   Filippis, Alejandro De
   Mazuski, John
   Bochicchio, Kelly M.
   Bochicchio, Grant V.
TI Negative Pressure Wound Therapy With and Without Instillation in
   Necrotizing Soft Tissue Infections
SO SURGICAL INFECTIONS
LA English
DT Article
DE necrotizing soft tissue infection; negative pressure wound therapy;
   negative pressure wound therapy with instillation
ID RETROSPECTIVE ANALYSIS; MORTALITY; PREDICTORS; MANAGEMENT
AB Background: Necrotizing soft tissue infections (NSTIs) are rare but deadly infections that require early and often extensive surgical debridement. After debridement, patients frequently have substantial morbidity because of large, open wounds. Hypothesis: Negative pressure wound therapy with instillation (NPWTi) results in higher wound closure rates compared with traditional negative pressure wound therapy (NPWT) or wet to dry dressings (moist wound care dressing). Patients and Methods: A prospectively maintained Acute and Critical Care Surgery database spanning 2008-2018 was queried for patients with a diagnosis of necrotizing fasciitis, Fournier gangrene, or gas gangrene. Data were collected on patient comorbidities, operative management, and clinical outcomes. Patients were stratified by use of moist wound care dressing, traditional NPWT, or NPWTi. Data were analyzed using analysis of variance (ANOVA), chi(2), and logistic regression. Results: During the 10-year study period, patients were treated for NSTI; 173 were managed with moist wound care dressing, 150 with NPWT, and 48 with NPWTi. Patients were similar in terms of demographics, body mass index (BMI), diabetes mellitus, and smoking rates. Overall, complication rates were not substantially different, but mortality was higher in the moist wound care dressing group (16.2% vs. 10.7% NPWT vs. 2.1% NPWTi; p = 0.02). In the moist wound care dressing group, 81.5% of patients had an open wound at discharge compared with 52.7% of the NPWT group and only 14.6% of the NPWTi group (p < 0.001). On multivariable regression, NPWTi was associated with closure rates five times higher than the NPWT group (odds ratio [OR], 5.28; 95% confidence interval [CI], 2.40-11.61; p < 0.001) after controlling for smoking status, intravenous drug use, number of operations, and involvement of the most common region of the body. Conclusions: Negative pressure wound therapy with instillation is associated with higher rates of wound closure without increasing complication rates in patients with NSTI compared with traditional NPWT or moist wound care dressing. Although prospective studies are needed, this indicates the potential to improve patient quality of life through reduced pain and outpatient home health needs.
C1 [Afzal, Hussain; Fonseca, Ricardo; Canas, Melissa; Diaz, Leonardo; Mazuski, John; Bochicchio, Kelly M.; Bochicchio, Grant V.] Washington Univ, Sch Med, Acute & Crit Care Surg, 660 South Euclid Ave,Campus Box 8109, St Louis, MO 63110 USA.
   [Dawson, Erin] Penn Med, Trauma & Surg Crit Care, Philadelphia, PA USA.
   [Filippis, Alejandro De] Dartmouth Hlth, Gen Surg, Lebanon, NH USA.
C3 Washington University (WUSTL); University of Pennsylvania; Pennsylvania
   Medicine
RP Afzal, H (通讯作者)，Washington Univ, Sch Med, Acute & Crit Care Surg, 660 South Euclid Ave,Campus Box 8109, St Louis, MO 63110 USA.
EM hussain.afzal@wustl.edu
RI ; Fonseca, Ricardo/JCO-8533-2023; hizmali, lokman/AAA-8899-2021;
   Batirel, Ayse/KUC-6287-2024; zerdali, esra/AAQ-3482-2021; Yardimci,
   Ahmet Cem/AAQ-8148-2021; Singil, Sarp/JAC-2738-2023; /AAF-5652-2021;
   Rasa, Huseyin/AAG-3531-2021; GUL, OZLEM/KUF-4319-2024; Şahin,
   Ahmet/IZP-6944-2023
OI Díaz Agurto, Leonardo/0000-0002-4261-2000; Dawson,
   Erin/0000-0003-0702-4032; Fonseca, Ricardo/0000-0003-2363-1270; 
CR Anaya DA, 2007, CLIN INFECT DIS, V44, P705, DOI 10.1086/511638
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NR 20
TC 13
Z9 15
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD APR 1
PY 2024
VL 25
IS 3
BP 199
EP 205
DI 10.1089/sur.2023.299
EA FEB 2024
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA A3T7Q
UT WOS:001179140700001
PM 38417035
DA 2026-07-24
ER
PT J
AU Wei, P
   Wu, LJ
   Xie, HT
   Chen, ZH
   Tan, RW
   Xu, ZR
AF Wei, Pei
   Wu, Lijiao
   Xie, Hongteng
   Chen, Zhaohong
   Tan, Rongwei
   Xu, Zhaorong
TI Application of a meshed artificial dermal scaffold and negative-pressure
   wound therapy in the treatment of full-thickness skin defects: a
   prospective in vivo study
SO BIOMATERIALS SCIENCE
LA English
DT Article
ID RECONSTRUCTION; INTEGRA; MECHANISM
AB Artificial dermal scaffolds (ADSs) have great value in repairing deep skin defects. However, problems such as unsatisfactory angiogenesis and local dropsy or empyema often occur, resulting in delayed or even failed wound healing. Negative pressure wound therapy (NPWT) is an effective therapy to promote wound healing or shorten wound bed preparation time. Studies on whether it can improve the effects of ADSs have never been interrupted, and no consensus has been reached. In this study, an improved ADS was prepared by mesh technology, physicochemical experiments were conducted, cell adhesion and proliferation were assessed with the meshed ADS, and in vivo experiments were conducted to investigate the effects of meshed ADS or ADS combined with NPWT in repairing full-thickness skin defects. The results showed that the meshed ADS showed through-layer channels arranged in parallel longitudinal and transverse intersections. The cell experiments confirmed the good cytocompatibility. The in vivo experiments showed that there were no differences in the take rate or contraction of grafted skin among all experiment groups. The meshed ADS exhibited good histocompatibility, and there were no differences in tissue inflammation, dermal angiogenesis, or degradation among all groups. In addition, necrosis, dropsy, or empyema of the dermal scaffold were found in all experiment groups except for the meshed ADS + NPWT group, which showed better wound repair results, including fewer scaffold-related complications and satisfactory skin graft survival and wound contraction. In conclusion, this novel meshed ADS, which has a regular through-layer mesh structure and possesses stable physicochemical properties and good biocompatibility, combined with NPWT can ensure adequate subdermal drainage and reduce the risk of scaffold-related complications, thereby improving the quality and efficiency of wound repair, promoting a broader application of biomaterials, and helping physicians and readers implement more effective wound management.
C1 [Wei, Pei; Xie, Hongteng; Chen, Zhaohong; Xu, Zhaorong] Fujian Med Univ, Burn & Wound Repair Dept, Union Hosp, Fuzhou 350001, Peoples R China.
   [Wei, Pei; Xie, Hongteng; Chen, Zhaohong; Xu, Zhaorong] Fujian Med Univ, Fujian Burn Inst, Union Hosp, Fuzhou 350001, Peoples R China.
   [Wei, Pei; Xie, Hongteng; Chen, Zhaohong; Xu, Zhaorong] Fujian Med Univ, Fujian Prov Key Lab Burn & Trauma, Union Hosp, Fuzhou 350001, Peoples R China.
   [Wu, Lijiao] Fujian Prov Hosp, Dept Orthoped Surg, South Branch, Fuzhou 350001, Peoples R China.
   [Wu, Lijiao] Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China.
   [Tan, Rongwei] Shenzhen Lando Biomat Co Ltd, GuangDong Engn Technol Res Ctr Implantable Med Pol, Shenzhen 518107, Peoples R China.
C3 Fujian Medical University; Fujian Medical University; Fujian Medical
   University; Fujian Provincial Hospital; Fujian Medical University
RP Xu, ZR (通讯作者)，Fujian Med Univ, Burn & Wound Repair Dept, Union Hosp, Fuzhou 350001, Peoples R China.; Xu, ZR (通讯作者)，Fujian Med Univ, Fujian Burn Inst, Union Hosp, Fuzhou 350001, Peoples R China.; Xu, ZR (通讯作者)，Fujian Med Univ, Fujian Prov Key Lab Burn & Trauma, Union Hosp, Fuzhou 350001, Peoples R China.
EM 234828306@qq.com
FU National Natural Science Foundation of China [[2021]76]; High-level
   Hospital and Clinical Specialty Discipline Construction Programme for
   Fujian Medical Development, China; Fujian Provincial Key Laboratory of
   Burn and Trauma [82002034]; National Natural Science Foundation of China
   [2021Y9068]; Joint Funds for the Innovation of Science and Technology,
   Fujian Province, China
FX This work was supported by the High-level Hospital and Clinical
   Specialty Discipline Construction Programme for Fujian Medical
   Development, China ([2021]76), the Fujian Provincial Key Laboratory of
   Burn and Trauma, the National Natural Science Foundation of China
   (82002034), and the Joint Funds for the Innovation of Science and
   Technology, Fujian Province, China (2021Y9068).
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   Pollard RLE, 2008, J PLAST RECONSTR AES, V61, P319, DOI 10.1016/j.bjps.2007.10.029
   POPE ER, 1990, VET CLIN N AM-SMALL, V20, P177, DOI 10.1016/S0195-5616(90)50009-1
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   Simman Richard, 2011, J Am Col Certif Wound Spec, V3, P55, DOI 10.1016/j.jcws.2012.03.001
   Stiefel D, 2009, J PEDIATR SURG, V44, P575, DOI 10.1016/j.jpedsurg.2008.07.006
   Weisel A, 2022, J TISSUE ENG REGEN M, V16, P1173, DOI 10.1002/term.3356
   Xu ZR, 2019, MAT SCI ENG C-MATER, V105, DOI 10.1016/j.msec.2019.110063
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NR 43
TC 4
Z9 4
U1 1
U2 3
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2047-4830
EI 2047-4849
J9 BIOMATER SCI-UK
JI Biomater. Sci.
PD MAR 26
PY 2024
VL 12
IS 7
BP 1914
EP 1923
DI 10.1039/d3bm01675g
EA MAR 2024
PG 10
WC Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA MA1J3
UT WOS:001179298700001
PM 38436071
OA hybrid
DA 2026-07-24
ER
PT J
AU Wen, JX
   Li, ZJ
   Chi, YR
   Chen, B
   Hong, T
   Liu, ZF
   Yu, NZ
   Wang, XJ
AF Wen, Junxian
   Li, Zhijin
   Chi, Yarong
   Chen, Bo
   Hong, Tao
   Liu, Zhifei
   Yu, Nanze
   Wang, Xiaojun
TI Vulvar migration of injected polyacrylamide hydrogel following breast
   augmentation: a case report and literature review
SO BMC WOMENS HEALTH
LA English
DT Article
DE Breast augmentation; Vulva; Polyacrylamide hydrogel; Migration; Case
   Report; Literature Review
ID COMPLICATIONS; MANAGEMENT; FEATURES; PATIENT; FILLER
AB BackgroundVulvar migration is a rare complication of filler injection for breast augmentation, generally presenting as repeated pain and fever. We will report a case of woman with polyacrylamide hydrogel breast injection develops vulvar abscess.Case presentationA woman with a history of polyacrylamide hydrogel breast injection was noted to have vulvar abscess due to migration of filler materials. Filler removal surgery and vacuum sealing drainage was performed for this patient. The patient was discharged from the hospital with no further complications. After a review of pertinent literature, only four previous case reports are found. Local inflammatory response, infection, large volume injections, inframammary fold destruction, hematogenous or lymphatic migrate, trauma, gravity and external pressure could play essential parts in the migration of injected filler.ConclusionPolyacrylamide hydrogel migration poses a worldwide challenge, necessitating personalized solutions. Our case study underscores the importance of comprehensive examinations for individuals with a history of filler breast injection when suspecting vulvar filler migration.
C1 [Wen, Junxian; Li, Zhijin; Liu, Zhifei; Yu, Nanze; Wang, Xiaojun] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Plast Surg, Beijing, Peoples R China.
   [Chi, Yarong] PUMC & Chinese Acad Med Sci, Peking Union Med Coll PUMC, Beijing, Peoples R China.
   [Chen, Bo] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Pathol, Beijing, Peoples R China.
   [Hong, Tao] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Gen Surg, Beijing, Peoples R China.
   [Hong, Tao; Yu, Nanze] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Int Med Serv, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Peking Union Medical College; Peking Union
   Medical College Hospital; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College Hospital; Peking
   Union Medical College; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College Hospital; Peking
   Union Medical College
RP Yu, NZ; Wang, XJ (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Plast Surg, Beijing, Peoples R China.; Yu, NZ (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Int Med Serv, Beijing, Peoples R China.
EM yunanze@pumch.cn; pumchwxj@163.com
RI ; tao, hong/HGA-0940-2022; wang, xiaojun/NFT-0476-2025
OI Wen, Junxian/0009-0004-5549-122X; 
FU National High Level Hospital Clinical Research Funding
FX No Statement Available
CR Adams WP, 2012, PLAST RECONSTR SURG, V130, p598E, DOI 10.1097/PRS.0b013e318262f607
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   U.S. Food and Drug Administration, Dermal Fillers (Soft Tissue Fillers)
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NR 33
TC 4
Z9 4
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6874
J9 BMC WOMENS HEALTH
JI BMC Womens Health
PD MAR 2
PY 2024
VL 24
IS 1
AR 152
DI 10.1186/s12905-024-02998-0
PG 9
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology
GA KI8N6
UT WOS:001179423300001
PM 38431590
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kaiser, S
   Verboket, RD
   Frank, J
   Marzi, I
   Janko, M
AF Kaiser, S.
   Verboket, R. D.
   Frank, J.
   Marzi, I.
   Janko, M.
TI Effectiveness of combined local therapy with antibiotics and fibrin vs.
   vacuum-assisted wound therapy in soft tissue infections: a retrospective
   study
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Infection; VAC; NPWT; Spray; Antibiotic; Fibrin; New therapy
ID SURGICAL SITE INFECTION; IN-VITRO; SEALANTS; DELIVERY; SYSTEM; GLUE;
   VANCOMYCIN; RELEASE; METAANALYSIS; DEFINITIONS
AB Purpose Soft tissue infections can be severe and life-threatening. Their treatment consists currently in radical surgical wound debridement and combined systemic antimicrobial therapy. Different side effects are possible. Local antibiotic therapy represents a new approach to reduce side effects and improve healing. The aim of this study is to assess the effectiveness of the local sprayed use of antibiotics with fibrin sealing compared with negative pressure wound therapy as an established treatment of soft-tissue infections. Methods In this retrospective study, patients with soft tissue infections who underwent surgical treatment were analysed. One group consists of patients, who received local fibrin-antibiotic spray (FAS) (n = 62). Patients treated by vacuum-assisted wound therapy (VAWT) as the established treatment were the control group (n = 57). Main outcomes were differences in the success of healing, the duration until healing and the number of needed operations. Results Clinical healing could be achieved for 55 patients (98.21%) in the FAS group vs. 47 patients (92.16%) in the VAWT group (p = 0.19). Time to require this was 10.65 +/- 10.38 days in the FAS group and 22.85 +/- 14.02 days in the VAWT group (p < 0.001). In the FAS group, patients underwent an average of 1.44 +/- 0.72 vs.3.46 +/- 1.66 operations in the VAWT group (p < 0.001). Conclusion Compared to vacuum-assisted wound therapy in soft tissue infections, local fibrin-antibiotic spray shows faster clinical healing and less needed operations. Leading to shorter hospital stays and more satisfied patients. The combination of sprayed fibrin and antibiotics can be seen as a promising and effective method.
C1 [Kaiser, S.; Verboket, R. D.; Frank, J.; Marzi, I.; Janko, M.] Goethe Univ Frankfurt, Univ Hosp, Dept Trauma Hand & Reconstruct Surg, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
C3 Goethe University Frankfurt; Goethe University Frankfurt Hospital
RP Verboket, RD (通讯作者)，Goethe Univ Frankfurt, Univ Hosp, Dept Trauma Hand & Reconstruct Surg, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
EM verboket@med.uni-frankfurt.de
RI Verboket, René Danilo/ABA-3870-2020
OI Verboket, René Danilo/0000-0003-1086-4016
FU Johann Wolfgang Goethe-Universitt, Frankfurt am Main (1022)
FX No Statement Available
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NR 61
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD AUG
PY 2024
VL 50
IS 4
SI SI
BP 1559
EP 1567
DI 10.1007/s00068-024-02483-1
EA MAR 2024
PG 9
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA I1I2R
UT WOS:001180363600002
PM 38466400
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Shi, JY
   Gao, Y
   Tian, JH
   Li, J
   Xu, JG
   Mei, F
   Li, Z
AF Shi, Jiyuan
   Gao, Ya
   Tian, Jinhui
   Li, Jiang
   Xu, Jianguo
   Mei, Fan
   Li, Zheng
TI Negative pressure wound therapy for treating pressure ulcers
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL;
   SPINAL-CORD-INJURY; RISK-FACTORS; COST-EFFECTIVENESS; BACTERIAL LOAD;
   CLINICAL-TRIAL; PREVALENCE; CARE; MANAGEMENT
AB Background
   Pressure ulcers, also known as bedsores, pressure sores, or pressure injuries, are localised damage to the skin and underlying soft tissue, usually caused by intense or long-term pressure, shear, or friction. Negative pressure wound therapy (NPWT) has been widely used in the treatment of pressure ulcers, but its effect needs to be further clarified. This is an update of a Cochrane Review first published in 2015.
   Objectives
   To evaluate the effectiveness of NPWT for treating adult with pressure ulcers in any care setting.
   Search methods
   On 13 January 2022, we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE (including In-Process & Other Non-Indexed Citations); Ovid Embase, and EBSCO CINAHL Plus. We also searched ClinicalTrials.gov and the WHO ICTRP Search Portal for ongoing and unpublished studies and scanned reference lists of relevant included studies as well as reviews, meta-analyses, and health technology reports to identify additional studies. There were no restrictions with respect to language, date of publication, or study setting.
   Selection criteria
   We included published and unpublished randomised controlled trials (RCTs) comparing the effects of NPWT with alternative treatments or different types of NPWT in the treatment of adults with pressure ulcers (stage II or above).
   Data collection and analysis
   Two review authors independently conducted study selection, data extraction, risk of bias assessment using the Cochrane risk of bias tool, and the certainty of the evidence assessment using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) methodology. Any disagreement was resolved by discussion with a third review author.
   Main results
   This review included eight RCTs with a total of 327 randomised participants. Six of the eight included studies were deemed to be at a high risk of bias in one or more risk of bias domains, and evidence for all outcomes of interest was deemed to be of very low certainty. Most studies had small sample sizes (range: 12 to 96, median: 37 participants).
   Five studies compared NPWT with dressings, but only one study reported usable primary outcome data (complete wound healing and adverse events). This study had only 12 participants and there were very few events; only one participant was healed in the study (risk ratio RR) 3.00, 95% confidence interval (CI) 0.15 to 61.74, very low-certainly evidence). There was no evidence of a difference in the number of participants with adverse events in the NPWT group and the dressing group, but the evidence for this outcome was also assessed as very low certainty (RR 1.25, 95% CI 0.64 to 2.44, very low-certainty evidence). Changes in ulcer size, pressure ulcer severity, cost, and pressure ulcer scale for healing (PUSH) sores were also reported, but we were unable to draw conclusions due to the low certainly of the evidence.
   One study compared NPWT with a series of gel treatments, but this study provided no usable data. Another study compared NPWT with 'moist wound healing', which did not report primary outcome data. Changes in ulcer size and cost were reported in this study, but we assessed the evidence as being of very low certainty; One study compared NPWT combined with internet-plus home care with standard care, but no primary outcome data were reported. Changes in ulcer size, pain, and dressing change times were reported, but we also assessed the evidence as being of very low certainty.
   None of the included studies reported time to complete healing, health-related quality of life, wound infection, or wound recurrence.
   Authors' conclusions The efficacy, safety, and acceptability of NPWT in treating pressure ulcers compared to usual care are uncertain due to the lack of key data on complete wound healing, adverse events, time to complete healing, and cost-effectiveness.
   Compared with usual care, using NPWT may speed up the reduction of pressure ulcer size and severity of pressure ulcer, reduce pain, and dressing change times. Still, trials were small, poorly described, had short follow-up times, and with a high risk of bias; any conclusions drawn from the current evidence should be interpreted with considerable caution. In the future, high-quality research with large sample sizes and low risk of bias is still needed to further verify the eJicacy, safety, and cost-eJectiveness of NPWT in the treatment of pressure ulcers. Future researchers need to recognise the importance of complete and accurate reporting of clinically important outcomes such as the complete healing rate, healing time, and adverse events.
C1 [Shi, Jiyuan; Li, Zheng] Chinese Acad Med Sci & Peking Union Med Coll, Sch Nursing, Beijing, Peoples R China.
   [Gao, Ya; Tian, Jinhui; Xu, Jianguo] Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Peoples R China.
   [Li, Jiang] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Canc Clin Med Res Ctr, Canc Hosp, Beijing, Peoples R China.
   [Mei, Fan] Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu, Peoples R China.
   [Mei, Fan] Sichuan Univ, West China Hosp, Cochrane China Ctr, Chengdu, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Lanzhou University; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Peking Union Medical
   College; Cancer Institute & Hospital - CAMS; Sichuan University; Sichuan
   University
RP Li, Z (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Sch Nursing, Beijing, Peoples R China.
EM zhengli@pumc.edu.cn
RI Li, Zheng/OHT-0437-2025; Shi, Jiyuan/ACB-6953-2022; Gao,
   Ya/HGA-2705-2022
OI Shi, Jiyuan/0000-0001-5099-9439; Gao, Ya/0000-0002-9280-4457
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NR 99
TC 27
Z9 33
U1 5
U2 38
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2023
IS 5
AR CD011334
DI 10.1002/14651858.CD011334.pub3
PG 61
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KU3M1
UT WOS:001182438700033
PM 37232410
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Manik, M
   Anandhi, A
   Sureshkumar, S
   Keerthi, AR
   Sudharshan, M
   Kate, V
AF Manik, Maharjan
   Anandhi, Amaranathan
   Sureshkumar, Sathasivam
   Keerthi, Andi Rajendharan
   Sudharshan, Mahalingam
   Kate, Vikram
TI Prophylactic Negative Pressure Wound Therapy in Reducing Surgical Site
   Infections in Closed Abdominal Incision: A Randomized Controlled Trial
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE surgical site infection; negative pressure wound therapy; clean
   contaminated wound; laparotomy
ID LAPAROTOMY INCISIONS; RISK; SURGERY
AB Objective: This study aimed to evaluate the efficacy of prophylactic negative pressure wound therapy (PNPWT) in reducing the incidence of surgical site infection (SSI) and other wound complications in closed abdominal incisions.
   Approach: This was a prospective, single-center, open-label parallel arm superiority randomized controlled trial conducted over 2 years. Participants were randomly assigned to PNPWT and standard surgical dressing (SSD) group. The occurrence of postoperative SSI within 30 days, other wound-related complications, length of hospital (LOH) stay, and readmission within 1 month among both the study group were studied.
   Results: A total of 140 participants were included, with 70 each randomized to the PNPWT and SSD groups. In this study, 28.5% and 5.8% developed SSI in the SSD and PNPWT groups, respectively (relative risk = 0.26; 95% confidence interval = 0.08-0.80; p = 0.001). Similarly, the incidence of seroma (7.2% vs. 18.5%, p = 0.016), wound dehiscence (0% vs. 4.2%, p = 0.244), superficial and deep SSI (5.7% vs. 24.3%, p = 0.001) and (0% vs. 4.2%, p = 0.244), and LOH stay (days) (9 vs. 10.5, p = 0.07) were less in PNPWT compared to SSD group. Innovation: Despite the advances in surgical care, SSI rates continue to be high. The present findings might facilitate the use of PNPWT as a novel preventive strategy to reduce SSI in closed abdominal incision.
   Conclusion: The PNPWT in closed incisions following elective laparotomy can reduce the incidence of SSI when compared to SSD. The use of PNPWT was associated with a lower incidence of superficial SSI and seroma but without significant reduction in hospital stay.
C1 [Manik, Maharjan; Anandhi, Amaranathan; Sureshkumar, Sathasivam; Keerthi, Andi Rajendharan; Sudharshan, Mahalingam; Kate, Vikram] Jawaharlal Inst Postgrad Med Educ & Res, Dept Surg, Pondicherry 605006, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research
RP Anandhi, A (通讯作者)，Jawaharlal Inst Postgrad Med Educ & Res, Dept Surg, Pondicherry 605006, India.
RI Amaranathan, Anandhi/K-1169-2019; Kate, Vikram/AAI-1547-2019
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NR 21
TC 3
Z9 5
U1 1
U2 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAR 1
PY 2024
VL 13
IS 3
BP 123
EP 130
DI 10.1089/wound.2023.0052
EA SEP 2023
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA A3Y5D
UT WOS:001182617600001
PM 37646410
DA 2026-07-24
ER
PT J
AU Pepe, G
   Chiarello, MM
   Bianchi, V
   Fico, V
   Altieri, G
   Tedesco, S
   Tropeano, G
   Molica, P
   Di Grezia, M
   Brisinda, G
AF Pepe, Gilda
   Chiarello, Maria Michela
   Bianchi, Valentina
   Fico, Valeria
   Altieri, Gaia
   Tedesco, Silvia
   Tropeano, Giuseppe
   Molica, Perla
   Di Grezia, Marta
   Brisinda, Giuseppe
TI Entero-Cutaneous and Entero-Atmospheric Fistulas: Insights into
   Management Using Negative Pressure Wound Therapy
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE enteric fistula; enterocutaneous fistula; entero-atmospheric fistula;
   negative pressure wound therapy; open abdomen
ID VACUUM-ASSISTED CLOSURE; TEMPORARY ABDOMINAL CLOSURE; SMALL-BOWEL
   FISTULAS; OPEN ABDOMEN; ENTEROCUTANEOUS FISTULA; ENTEROATMOSPHERIC
   FISTULA; GASTROINTESTINAL COMPLICATIONS; SURGICAL COMPLICATIONS;
   INTESTINAL PERFORATION; OPERATIVE MANAGEMENT
AB Enteric fistulas are a common problem in gastrointestinal tract surgery and remain associated with significant mortality rates, due to complications such as sepsis, malnutrition, and electrolyte imbalance. The increasingly widespread use of open abdomen techniques for the initial treatment of abdominal sepsis and trauma has led to the observation of so-called entero-atmospheric fistulas. Because of their clinical complexity, the proper management of enteric fistula requires a multidisciplinary team. The main goal of the treatment is the closure of enteric fistula, but also mortality reduction and improvement of patients' quality of life are fundamental. Successful management of patients with enteric fistula requires the establishment of controlled drainage, management of sepsis, prevention of fluid and electrolyte depletion, protection of the skin, and provision of adequate nutrition. Many of these fistulas will heal spontaneously within 4 to 6 weeks of conservative management. If closure is not accomplished after this time point, surgery is indicated. Despite advances in perioperative care and nutritional support, the mortality remains in the range of 15 to 30%. In more recent years, the use of negative pressure wound therapy for the resolution of enteric fistulas improved the outcomes, so patients can be successfully treated with a non-operative approach. In this review, our intent is to highlight the most important aspects of negative pressure wound therapy in the treatment of patients with enterocutaneous or entero-atmospheric fistulas.
C1 [Pepe, Gilda; Bianchi, Valentina; Fico, Valeria; Altieri, Gaia; Tedesco, Silvia; Tropeano, Giuseppe; Molica, Perla; Di Grezia, Marta; Brisinda, Giuseppe] Fdn Policlin Univ A Gemelli, Emergency Surg & Trauma Ctr, Dept Abdominal & Endocrine Metab Med & Surg Sci, IRCCS, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
   [Chiarello, Maria Michela] Prov Hlth Author, Dept Surg, Gen Surg Operat Unit, I-87100 Cosenza, Italy.
   [Brisinda, Giuseppe] Catholic Sch Med Agostino Gemelli, Dept Med & Surg, Largo Francesco Vito 1, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Brisinda, G (通讯作者)，Fdn Policlin Univ A Gemelli, Emergency Surg & Trauma Ctr, Dept Abdominal & Endocrine Metab Med & Surg Sci, IRCCS, Largo Agostino Gemelli 8, I-00168 Rome, Italy.; Brisinda, G (通讯作者)，Catholic Sch Med Agostino Gemelli, Dept Med & Surg, Largo Francesco Vito 1, I-00168 Rome, Italy.
EM gilda.pepe@policlinicogemelli.it; michela.chiarello@aspcs.it;
   valentina.bianchi@guest.policlinicogemelli.it;
   valeria.fico@policlinicogemelli.it;
   gaia.altieri@guest.policlinicogemelli.it; silvia.tedesco55@gmail.com;
   giuseppe.tropeano@guest.policlinicogemelli.it; perla_molica@hotmail.it;
   marta.digrezia@policlinicogemelli.it;
   giuseppe.brisinda@policlinicogemelli.it
RI chiarello, MARIA MICHELA/GVS-7109-2022; Fico, Valeria/KUF-2684-2024;
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OI chiarello, MARIA MICHELA/0000-0003-3455-0062; Tedesco,
   Silvia/0000-0003-4693-4725; Fico, Valeria/0000-0003-1619-4164; Brisinda,
   Giuseppe/0000-0001-8820-9471
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NR 162
TC 12
Z9 15
U1 0
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2024
VL 13
IS 5
AR 1279
DI 10.3390/jcm13051279
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KV2N2
UT WOS:001182674000001
PM 38592102
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Marra, C
   Pentangelo, P
   Losco, L
   Ceccaroni, A
   Barbato, A
   Alfano, C
AF Marra, Caterina
   Pentangelo, Paola
   Losco, Luigi
   Ceccaroni, Alessandra
   Barbato, Alfonso
   Alfano, Carmine
TI Lower Extremity Trauma: A Multidimensional Reconstructive Approach with
   Hyperbaric Oxygen Therapy
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE lower limb trauma; soft tissue defect; lower extremity reconstruction;
   split thickness skin graft; acellular dermal matrix; ADM; negative
   pressure wound therapy; NPWT; hyperbaric oxygen therapy; HBOT
ID PRESSURE WOUND THERAPY; PLASTIC-SURGERY; MANAGEMENT; INFECTION; DEFECTS;
   SALVAGE
AB Background: Distal lower extremity reconstruction is challenging. This study aims to propose a protocol for the treatment of traumatic soft tissue defects. The key concept is to combine the surgical armamentarium of the reconstructive surgeon with the advantages provided by hyperbaric oxygen therapy. Methods: This retrospective study analyzed data of 57 patients affected with unilateral or bilateral lower extremity trauma distal to the knee and involving soft tissues with no indication of immediate reconstruction between 2010 and 2021. Before the reconstructive procedure, all the patients underwent a stick swab procedure for the collection of microbiological samples and debridement. Patients were divided into two treatment groups and only one group underwent a combined therapeutic procedure with hyperbaric oxygen therapy. Negative pressure wound therapy (NPWT) was employed only if deemed necessary according to the defect's depth and wound exudate. Surgical techniques, outcomes, and complications were discussed. Results: All patients achieved a complete recovery with no major complications and only minor complications observed. The study group treated with HBOT had a lower complication rate and lower percentages of minimal and partial graft loss compared with the same complications observed in the control group. No patients experienced HBOT-related complications. Significant reductions in the time to complete healing and the time from reconstruction to healing were found (p = 0.002 and p < 0.00001, respectively). Conclusions: A lower complication rate was observed in the group treated with HBOT. The administration of HBOT prior to soft tissue reconstruction significantly reduced the time to complete healing and the time interval from skin grafting to healing. However, prospective studies and randomized trials with larger cohorts should be designed to investigate the efficacy of HBOT for the treatment of lower extremity injuries with extensive soft tissue defects.
C1 [Marra, Caterina; Pentangelo, Paola; Losco, Luigi; Ceccaroni, Alessandra; Alfano, Carmine] Univ Salerno, Dept Med Surg & Dent, Plast Surg Unit, I-84081 Baronissi, SA, Italy.
   [Barbato, Alfonso] Azienda Osped Univ OO RR San Giovanni di Dio e Rug, Plast Surg Unit, I-84131 Salerno, SA, Italy.
C3 University of Salerno
RP Losco, L (通讯作者)，Univ Salerno, Dept Med Surg & Dent, Plast Surg Unit, I-84081 Baronissi, SA, Italy.
EM camarra@unisa.it; ppentangelo@unisa.it; llosco@unisa.it
RI ; Ceccaroni, Alessandra/JCO-7296-2023; Losco, Luigi/AAC-3499-2020
OI marra, caterina/0009-0004-8826-7830; Pentangelo,
   Paola/0000-0002-9067-4177
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NR 42
TC 7
Z9 9
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2024
VL 13
IS 5
AR 1407
DI 10.3390/jcm13051407
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KX6L0
UT WOS:001183302900001
PM 38592225
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mankarious, MM
   Eng, NL
   Portolese, AC
   Deutsch, MJ
   Lynn, P
   Kulaylat, AS
   Scow, JS
AF Mankarious, M. M.
   Eng, N. L.
   Portolese, A. C.
   Deutsch, M. J.
   Lynn, P.
   Kulaylat, A. S.
   Scow, J. S.
TI Closed-incision negative-pressure wound therapy reduces superficial
   surgical site infections after open colon surgery: an NSQIP Colectomy
   Study
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE Surgical site infections; Negative-pressure wound therapy; Incisional
   wound vac; Colon surgery; Readmissions
ID ABDOMINAL INCISIONS; COLORECTAL SURGERY; RISK; METAANALYSIS; LAPAROTOMY;
   PREVENTION; PATIENT
AB Background: The use of closed-incision negative-pressure wound therapy (iNPWT) has increased in the last decade across surgical fields, including colectomy. Aim: To compare postoperative outcomes associated with use of iNPWT following open colectomy from a large national database. Methods: A retrospective review of patients who underwent operations from 2015 to 2020 was performed using the National Surgical Quality Improvement Program (NSQIP) Targeted Colectomy Database. Intraoperative placement of iNPWT was identified in patients undergoing open abdominal operations with closure of all wound layers including skin. Propensity score matching was performed to define a control group who underwent closure of all wound layers without iNPWT. Patients were matched in a 1:4 (iNPWT vs control) ratio and postoperative rates of superficial, deep and organ-space surgical site infection (SSI), wound disruption, and readmission. Findings: A matched cohort of 1884 was selected. Patients with iNPWT had longer median operative time (170 (interquartile range: 129-232) vs 161 (114-226) min; P<0.05). Compared to patients without iNPWT, patients with iNPWT experienced a lower rate of 30-day superficial incisional SSI (3% vs 7%; P<0.05) and readmissions (10% vs 14%; P<0.05). iNPWT did not decrease risk of deep SSI, organ-space SSI, or wound disruption. Conclusion: Although there is a slightly increased operative time, utilization of iNPWT in open colectomy is associated with lower odds of superficial SSI and 30-day readmission. This suggests that iNPWT should be routinely utilized in open colon surgery to improve patient outcomes. (c) 2024 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
C1 [Mankarious, M. M.; Eng, N. L.; Portolese, A. C.] Penn State Univ, Coll Med, Dept Surg, Hershey, PA USA.
   [Deutsch, M. J.; Lynn, P.; Kulaylat, A. S.; Scow, J. S.] Penn State Univ, Coll Med, Dept Surg, Div Colon & Rectal Surg, 500 Univ Dr, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Scow, JS (通讯作者)，Penn State Univ, Coll Med, Dept Surg, Div Colon & Rectal Surg, 500 Univ Dr, Hershey, PA 17033 USA.
EM jscow@pennstatehealth.psu.edu
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NR 39
TC 2
Z9 3
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD MAR
PY 2024
VL 145
BP 187
EP 192
DI 10.1016/j.jhin.2024.01.005
EA FEB 2024
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA LG6U4
UT WOS:001185679800001
PM 38272123
DA 2026-07-24
ER
PT J
AU Kim, Y
   Kong, CG
   Park, HY
   Lee, KS
   Sur, YJ
AF Kim, Youngwoo
   Kong, Chae Gwan
   Park, Ho Youn
   Lee, Kwan Soo
   Sur, Yoo Joon
TI Clinical and radiographic outcomes of negative pressure wound therapy
   combined with polymethylmethacrylate sealant for wound management of
   Gustilo type III open tibia fractures
SO ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
LA English
DT Article
DE Open; Free tissue flaps; Negative-pressure wound therapy; Polyurethane
   foam; Polymethylmethacrylate; Tibia fractures
ID VACUUM-ASSISTED CLOSURE; FLAP RECONSTRUCTION; DAMAGE CONTROL;
   INSTILLATION; TRAUMA
AB Objective: This study aimed to introduce a new wound management method combining negative pressure wound therapy and polymethylmethacrylate sealant for Gustilo type III open tibia fractures and to evaluate its clinical outcomes. Methods: Among 186 patients who visited our institution for the treatment of open tibia fractures between January 2016 and December 2019, 20 male patients who sustained Gustilo type III open tibia fractures and were compelled to undergo delayed flap coverage using negative pressure wound therapy combined with polymethylmethacrylate sealant due to initial critical condition were enrolled in this study. We retrospectively investigated patients' demographics, interval between the injury and flap coverage, number of negative pressure wound therapy changes, flap survival, bone union time, and infection-induced complications. Results: The mean interval from injury until flap coverage was 27.8 (range, 8-63) days. Most soft -tissue defects were reconstructed using free flaps (14/20, 70%); the anterolateral thigh flap was the most frequently used flap (12/20, 60%) in this study. Among 20 flaps transferred, 16 flaps (80%) survived uneventfully, 1 flap (5%) developed partial necrosis, and 3 flaps (15%) failed. The mean follow-up period was 22.7 (range, 12- 43) months. A total of 17 patients (85%) achieved tibia fracture union. The mean bone union time was 31 (range, 12-81) weeks. With regard to infection-induced complications, 3 patients (15%) developed osteomyelitis and no patient showed superficial surgical site infection. Conclusion: Combination therapy using negative pressure wound therapy and polymethylmethacrylate sealant serves as a useful and reliable therapeutic strategy for wound management of Gustilo type III open tibia fractures, especially when delayed soft -tissue reconstruction is unavoidable. Level of Evidence: Level IV, Therapeutic Study.
C1 [Kim, Youngwoo; Kong, Chae Gwan; Park, Ho Youn; Lee, Kwan Soo; Sur, Yoo Joon] Catholic Univ Korea, Coll Med, Dept Orthoped Surg, Seoul, South Korea.
C3 Catholic University of Korea
RP Sur, YJ (通讯作者)，Catholic Univ Korea, Coll Med, Dept Orthoped Surg, Seoul, South Korea.
EM yoojoon@catholic.ac.kr
RI /B-9927-2008
CR [Anonymous], NATL HEALTHCARE SAFE
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 36
TC 2
Z9 3
U1 0
U2 1
PU TURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY
PI ISTANBUL
PA SEHREMINI MAH KOYUNCU SK CIGDEM APT NO 4 D 5 FATIH, ISTANBUL, 00000,
   Turkiye
SN 1017-995X
EI 2589-1294
J9 ACTA ORTHOP TRAUMATO
JI Acta Orthop. Traumatol. Turc.
PD NOV
PY 2023
VL 57
IS 6
DI 10.5152/j.aott.2023.22104
PG 103
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA LK2P3
UT WOS:001186631200015
PM 37737582
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, Y
   Dong, GQ
   Xie, Y
   Wang, J
AF Li, Yan
   Dong, Guiqiu
   Xie, Yun
   Wang, Jie
TI Vacuum sealing drainage technique combined with carbon nanomaterial
   dressings applied in the treatment of skin wounds
SO POSTEPY DERMATOLOGII I ALERGOLOGII
LA English
DT Article
DE limb trauma; vacuum sealing drainage technique; carbon nanomaterial
   dressings; nursing intervention
ID LIMB SALVAGE; TRAUMA
AB Introduction: Limb trauma (LT) encompasses a variety of conditions and currently poses certain therapeutic chal- lenges in clinical practice. Aim: To assess the effectiveness of applying the vacuum sealing drainage (VSD) technique combined with carbon nanomaterial (CNM) dressings in the nursing treatment of LT patients. Material and methods: Eighty-six LT patients were enrolled into a control (Ctrl) group and an experimental (Exp) group. Patients in the Ctrl group underwent conventional wound cleansing and drainage methods with regular dressings, while those in the Exp group received VSD combined with CNM dressings. Both groups received the same nursing procedures. Various indicators were observed and compared to analyse the final outcomes. Results: The Exp group exhibited a higher favourable wound healing (FWH) rate, overall limb functional recovery (LFR) rate, and nursing satisfaction compared to the Ctrl group (p < 0.05). Meanwhile, patients in the Exp group experienced a greatly lower incidence of complications (IOC), pain scores, and average hospital stays (HS), presenting statistically/significant differences compared to those in the Ctrl group (p < 0.05). The combination of the VSD technique with CNM dressings demonstrated advantages in nursing treatment of LT patients. This approach could enhance rates of FWH, reduce IOC, alleviate postoperative pain, facilitate LFR, and shorten HS. Furthermore, patients in the Exp group expressed higher nursing satisfaction. Conclusions: Results of this work yielded a novel therapeutic option for clinical practice, enhancing treatment outcomes and rehabilitation processes for LT patients.
C1 [Li, Yan] Soochow Univ, Dushu Lake Hosp, Wound Care Clin Outpatient, Suzhou, Jiangsu, Peoples R China.
   [Dong, Guiqiu] Shanghai Jiao Tong Univ, Suzhou Kowloon Hosp, Med Coll, Dept Orthopaed 2, Suzhou, Jiangsu, Peoples R China.
   [Xie, Yun] Soochow Univ, Affiliated Hosp 1, Dept Anaesthesiol & Surg, Suzhou, Jiangsu, Peoples R China.
   [Wang, Jie] Soochow Univ, Dushu Lake Hosp, Dept Nursing, Suzhou, Jiangsu, Peoples R China.
C3 Soochow University - China; Shanghai Jiao Tong University; Soochow
   University - China; Soochow University - China
RP Wang, J (通讯作者)，Soochow Univ, Dushu Lake Hosp, Dept Nursing, Suzhou, Jiangsu, Peoples R China.
EM pingke28079729@163.com
CR Benitez Aurelie, 2021, Rev Infirm, V70, P31, DOI [10.1016/j.revinf.2020.11.011, 10.1016/j.revinf.2020.11.011]
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NR 21
TC 0
Z9 1
U1 1
U2 6
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1642-395X
EI 2299-0046
J9 POSTEP DERM ALERGOL
JI Postep. Dermatol. Alergol.
PY 2024
VL 41
IS 1
BP 128
EP 135
DI 10.5114/ada.2024.136036
PG 8
WC Allergy; Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Dermatology
GA LL4L4
UT WOS:001186941500010
PM 38533359
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Bieler, D
   Franke, A
   Völlmecke, M
   Hentsch, S
   Markewitz, A
   Kollig, E
AF Bieler, D.
   Franke, A.
   Voellmecke, M.
   Hentsch, S.
   Markewitz, A.
   Kollig, E.
TI Treatment regimen for deep sternal wound infections after cardiac
   surgical interventions in an interdisciplinary approach
SO UNFALLCHIRURGIE
LA German
DT Article
DE Sternotomy; Interdisciplinary approach; Osteosynthesis; Outcome;
   Comorbidities
ID VACUUM-ASSISTED CLOSURE; PLATELET-RICH PLASMA; RATIONAL APPROACH;
   GLYCEMIC CONTROL; RISK-FACTORS; MUSCLE FLAP; RECONSTRUCTION;
   MEDIASTINITIS; STERNOTOMY; THERAPY
AB The aim of this article is to present the importance of a structured and situation-adapted approach based on the diagnostic and therapeutic strategy in the interdisciplinary treatment of 54 patients with deep sternal wound infections (DSWI) after cardiac surgical interventions and the results achieved. The patients were 41 men and 13 women with an average age of 65.1 years, who developed a DSWI after a cardiac surgical intervention during the period 2003-2016. The treatment strategy included a thorough debridement including the removal of indwelling foreign material, the reconstruction with a stable re-osteosynthesis after overcoming the infection and if necessary, situation-related surgical flaps for a defect coverage with a good blood supply and mandatory avoidance of dead spaces. A total of 146 operations were necessary (average 2.7 operations/patient, range 1-7 operations). In 24.1% of the cases a one-stage approach could be carried out. In 41 patients negative pressure wound therapy (NPWT) with programmed sponge changing was used for wound conditioning (mean 5 changes, standard deviation, SD +/- 5.6 changes over 22 days, SD +/- 23.9 days, change interval every 3-4 days in 40.7% of the cases). In 33 patients a bilateral myocutaneous pectoralis major flap was used, in 4 patients a vertical rectus abdominis myocutaneous (VRAM) flap and in 7 patients both were carried out. A total of 43 osteosynthesis procedures were carried out on the sternum with fixed-angle titanium plates. Of the patients 7 died during intensive care unit treatment (total mortality 13%, n=5, 9.3% <= 30 days) or in the later course. Of the patients 47 (87.1%) could be discharged with a cleansed infection. In 2 patients the implant was removed after 2 years due to loosening.
C1 [Bieler, D.; Franke, A.; Voellmecke, M.; Hentsch, S.; Kollig, E.] Bundeswehrzent Krankenhaus Koblenz, Klin Unfallchirurg & Orthopadie Wiederherstellugs, Verbrennungsmed, Rubenacherstr 170, D-56072 Koblenz, Germany.
   [Bieler, D.] Univ Klinikum Dusseldorf, Klin Orthopadie & Unfallchirurg, Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf Hospital
RP Bieler, D (通讯作者)，Bundeswehrzent Krankenhaus Koblenz, Klin Unfallchirurg & Orthopadie Wiederherstellugs, Verbrennungsmed, Rubenacherstr 170, D-56072 Koblenz, Germany.
EM danbieler@uni-duesseldorf.de
RI Bieler, Dan/HZL-5995-2023
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 52
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2731-7021
EI 2731-703X
J9 UNFALLCHIRURGIE
JI Unfallchirurgie
PD MAR
PY 2024
VL 127
IS 3
BP 211
EP 220
DI 10.1007/s00113-023-01394-x
EA DEC 2023
PG 10
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA LL6H3
UT WOS:001186991000007
PM 38085276
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Sun, HJ
   Si, SW
   Liu, XK
   Geng, HF
   Liang, J
AF Sun, Haojie
   Si, Shanwen
   Liu, Xuekui
   Geng, Houfa
   Liang, Jun
TI Evaluation of a new low-cost negative pressure wound therapy in the
   treatment of diabetic foot ulcers
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE low-cost; diabetic foot ulcers; negative pressure wound therapy; wound;
   wound care; wound dressing wound healing
ID VACUUM-ASSISTED CLOSURE; MOIST
AB Objective: To investigate the effectiveness of a new and low-cost negative pressure wound therapy (LC-NPWT) in the treatment of diabetic foot ulcers (DFUs). Method: In this retrospective cohort study, patients from our inpatient clinic with Wagner grade 3 DFUs were given LC-NPWT or conventional wound dressings. The primary outcome was the wound healing rates. Complete wound healing, defined as complete re-epithelialisation of the wound, was recorded during the two months of follow-up. The definition of complete epidermis of the wound was that the skin was closed (100% re-epithelialisation), with no drainage or dressing. The secondary outcomes were the number of inpatient days and surgical procedures, and outcomes after hospital discharge. The wound score from the Bates-Jensen wound assessment tool and the levels of the inflammation factors procalcitonin (PCT), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were compared between the two groups. The Kaplan-Meier survival estimate was used to examine the cumulative wound healing rate. Results: The study cohort comprised 41 patients. The two-month wound healing rate was higher in patients in the LC-NPWT group than in the control group (15/21 (71.4%) versus 8/20 (40.0%), respectively; p=0.043). At the end of the two-month follow-up period, the cumulative wound healing rate was higher in the LC-NPWT group than in the control group (p=0.032). Patients in the LC-NPWT group had fewer inpatient days (19.3 +/- 3.84 versus 25.05 +/- 4.81; p<0.001) and shorter duration of antibiotic use (32.14 +/- 3.89 days versus 36.10 +/- 5.80 days; p=0.014) than those who received conventional wound dressings. There were significant improvements in mean wound score between the LC-NPWT group and the control group (p<0.001). After one week of treatment, the blood levels of PCT (0.03 +/- 0.30ng/ml versus 0.07 +/- 0.08ng/ml; p=0.039), CRP (14.55 +/- 13.40mg/l versus 24.71 +/- 18.10mg/l; p=0.047) and ESR (42.05 +/- 29.29mm/h versus 61.65 +/- 22.42mm/h; p=0.021) were lower in patients who received LC-NPWT than those who received conventional wound dressings. Conclusion: LC-NPWT is effective in the treatment of DFUs and provides a cheaper alternative for patients with DFUs that could potentially alleviate the economic distress these patients endure. Declaration of interest: The authors have no conflicts of interest.
C1 [Sun, Haojie; Liu, Xuekui; Geng, Houfa] Southeast Univ, Xuzhou Cent Hosp, Xuzhou Clin Sch, Affiliated XuZhou Hosp,Med Coll,Xuzhou Med Coll, Xuzhou 221009, Jiangsu, Peoples R China.
   [Si, Shanwen; Liang, Jun] Xuzhou Med Univ, Xuzhou 221000, Jiangsu, Peoples R China.
C3 Southeast University - China; Xuzhou Medical University; Xuzhou Medical
   University
RP Geng, HF (通讯作者)，Southeast Univ, Xuzhou Cent Hosp, Xuzhou Clin Sch, Affiliated XuZhou Hosp,Med Coll,Xuzhou Med Coll, Xuzhou 221009, Jiangsu, Peoples R China.; Liang, J (通讯作者)，Xuzhou Med Univ, Xuzhou 221000, Jiangsu, Peoples R China.
EM genghoufa@njmu.edu.cn; mwlj521@njmu.edu.cn
RI Houfa, Geng/ABI-6352-2020; Sun, Haojie/LRT-6797-2024
FU Xuzhou Primary Research & Development projects [KC21274]; Affiliated
   Hospital of Xuzhou Medical University Development foundation
   [XYFM2020010]; Jiangsu provincial primary talents program
   [ZBRCC2016022]; Pengcheng Talents-Medical Youth Reserve Talents
   [XWRCHT20220004]
FX This work was supported by Xuzhou Primary Research & Development
   projects, KC21274; Affiliated Hospital of Xuzhou Medical University
   Development foundation, XYFM2020010; Jiangsu provincial primary talents
   program, ZBRCC2016022; Pengcheng Talents-Medical Youth Reserve Talents,
   XWRCHT20220004.
CR [Anonymous], 2010, J Wound Ostomy Continence Nurs, V37, P378
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NR 28
TC 0
Z9 0
U1 3
U2 4
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2024
VL 33
SU 2A
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA LN3E9
UT WOS:001187436200001
DA 2026-07-24
ER
PT J
AU Zuo, J
   Zhu, Y
   Yang, F
   Yang, Y
   Yang, JT
   Huang, ZL
   Cheng, B
AF Zuo, Jun
   Zhu, Yi
   Yang, Feng
   Yang, Yong
   Yang, Juntao
   Huang, Ze Lin
   Cheng, Biao
TI Polyurethane foam dressing with non-adherent membrane improves negative
   pressure wound therapy in pigs
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE blood perfusion; negative pressure wound therapy; non-adherent membrane;
   polyurethane dressing; polyvinyl alcohol dressing; wound; wound care;
   wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; CONTRACTION; GRAFTS;
   DEVICE; STATE
AB Objective: Negative pressure wound therapy (NPWT) is considered to be an effective technique to promote the healing of various wounds. The aim of this study was to evaluate different wound dressings combined with NPWT in treating wounds in Wuzhishan pigs. Method: Excisions were made in the backs of the pigs and were covered with polyvinyl alcohol (PVA) dressing, polyurethane (PU) dressing or PU dressing with non -adherent membrane (PU-non-ad). NPWT was applied to the wound site. In the control group, basic occlusive dressing (gauze) without NPWT was applied. On days 0, 3, 7, 14, 21 and 28 post -surgery, the wound size was measured during dressing change, and wound healing rate (WHR) was calculated. In addition, blood perfusion within 2cm of the surrounding wound was measured by laser doppler flowmetry. Dressing specimen was collected and microbiology was analysed. Granulation tissues from the central part of the wounds were analysed for histology, vascular endothelial growth factor (VEGF) and cluster of differentiation 31 (CD31) mRNA expression. Results: The PU-non-ad-NPWT significantly (p<0.01) accelerated wound healing in the pigs. Further pathological analysis revealed that the non -adherent membrane effectively protected granulation tissue formation in PU-NPWT treated wounds. The blood perfusion analysis suggested that the non -adherent membrane improved the blood supply to the wound area. Microbiological analysis showed that non -adherent membrane decreased the bacterial load in the PU-NPWT dressing. VEGF and CD31 mRNA expression was upregulated in the wound tissue from the PU-non-ad-NPWT treated groups. Conclusion: In this study, the PU dressing with non -adherent membrane was an ideal dressing in NPWT-assisted wound healing. Declaration of interest: This work was supported by the Science and Technology Plan Project of Guangdong province in China (2015B020233012) and the Youth Science Fund Project of Natural Science Foundation of Hunan Province in China (2021JJ40487).
C1 [Zuo, Jun] Southern Med Univ, Sch Clin Med 1, Guangzhou 510000, Peoples R China.
   [Zuo, Jun; Zhu, Yi; Yang, Feng; Yang, Yong; Yang, Juntao; Huang, Ze Lin] Univ South China, Affiliated Hosp 2, Hengyang 421000, Peoples R China.
   [Cheng, Biao] PLA, Gen Hosp Southern Theater Command, Dept Burn & Plast Surg, Guangzhou 510000, Peoples R China.
C3 Southern Medical University - China; University of South China; Southern
   Theater Command General Hospital
RP Cheng, B (通讯作者)，PLA, Gen Hosp Southern Theater Command, Dept Burn & Plast Surg, Guangzhou 510000, Peoples R China.
EM chengbiaocheng@163.com
CR Anesäter E, 2011, INT WOUND J, V8, P336, DOI 10.1111/j.1742-481X.2011.00790.x
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   Borgquist O, 2010, OSTOMY WOUND MANAG, V56, P60
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   Li XQ, 2015, INT J CLIN EXP MED, V8, P3506
   Malmsjo Malin, 2012, Eplasty, V12, pe5
   Malmsjö M, 2009, WOUND REPAIR REGEN, V17, P200, DOI 10.1111/j.1524-475X.2009.00461.x
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   Plikaitis CM, 2006, EXPERT REV MED DEVIC, V3, P175, DOI 10.1586/17434440.3.2.175
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
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   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
NR 34
TC 0
Z9 0
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2024
VL 33
SU 2A
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA LN3E9
UT WOS:001187436200002
DA 2026-07-24
ER
PT J
AU Ivert, T
   Berge, A
   Bratt, S
   Dalén, M
AF Ivert, Torbjorn
   Berge, Andreas
   Bratt, Sorosh
   Dalen, Magnus
TI Incidence and healing times of postoperative sternal wound infections: a
   retrospective observational single-centre study
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE Superficial sternal wound infection; mediastinitis; negative pressure
   wound therapy
ID OPEN-HEART-SURGERY; RISK-FACTORS; DEEP; COMPLICATIONS; MEDIASTINITIS;
   MANAGEMENT
AB Objectives: Analyses of incidence and time required to heal sternal wound infections after heart surgery performed via a median sternotomy between 2020 and 2022. Results: Superficial wound infections (SWI) were five times more common (2.7%) than mediastinitis (0.5%) among 2693 patients. The median time between the operation and diagnosis of SWI was 26 (interquartile range [IQR] 15-33) days vs. 16 (IQR 9-25) days for mediastinitis (p = .12). Gram-negative bacteria caused 44% of the 85 infections. Sternal wound infection correlated to higher body mass index, female sex, smoking, diabetes mellitus, previous myocardial infarction, coronary artery bypass grafting, use of internal mammary graft, and re-entry for postoperative bleeding. Eight of 59 patients (13.6%) with sternal wound infections had bilateral mammary grafts, compared to 102 of 1191 patients (8.6%) without wound infections (p = .28). Negative pressure wound therapy was always used to treat mediastinitis and applied in 63% of patients with SWI. Two of 13 patients with mediastinitis (15%) and none of 72 patients with SWI died within 90 days after the operation. The median time until the wound healed was 1.9 (IQR 1.3-3.7) months after SWI vs. 1.7 (IQR 1.3-5.3) months after mediastinitis (p = .63). Six patients (7%) required longer than one year to treat the infection. Conclusions: Postoperative sternal wound infections usually appeared several weeks after surgery and were associated with factors as high body mass index, diabetes mellitus and coronary artery bypass. SWI were more common than mediastinitis and often required negative pressure wound therapy and similar treatment time as mediastinitis.
C1 [Ivert, Torbjorn; Bratt, Sorosh; Dalen, Magnus] Karolinska Univ Hosp, Dept Cardiothorac Surg, Eugeniavagen 23,C12 28, S-17176 Stockholm, Sweden.
   [Ivert, Torbjorn; Bratt, Sorosh; Dalen, Magnus] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Berge, Andreas] Karolinska Inst, Dept Med, Unit Infect Dis, Stockholm, Sweden.
   [Berge, Andreas] Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet; Karolinska Institutet; Karolinska Institutet; Karolinska
   University Hospital
RP Ivert, T (通讯作者)，Karolinska Univ Hosp, Dept Cardiothorac Surg, Eugeniavagen 23,C12 28, S-17176 Stockholm, Sweden.
EM torbjorn.ivert@ki.se
RI B, Andreas/KEI-3902-2024
FU Fredrik Lundberg
FX No Statement Available
CR Abdelnoor M, 2019, SCAND CARDIOVASC J, V53, P226, DOI 10.1080/14017431.2019.1642508
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NR 21
TC 4
Z9 7
U1 1
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PD DEC 31
PY 2024
VL 58
IS 1
AR 2330349
DI 10.1080/14017431.2024.2330349
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LN7Q7
UT WOS:001187552100001
PM 38500294
OA Bronze
DA 2026-07-24
ER
PT J
AU Gomez, G
   Sie, KCY
   Osterbauer, B
   Arom, G
   Kochhar, A
AF Gomez, Gabriel
   Sie, Kathleen C. Y.
   Osterbauer, Beth
   Arom, Gabriel
   Kochhar, Amit
TI Salvage of Infected Alloplastic Ear Reconstructions via Negative
   Pressure Wound Therapy
SO LARYNGOSCOPE
LA English
DT Article
DE ear deformity; microtia; negative-pressure wound therapy; pediatric;
   porous polyethylene PPE framework
AB This is the first description of Negative Pressure Wound Therapy (NPWT) use in rescuing alloplastic ear reconstructions. Previously considered a sign of certain impending failure, severe infections with frank purulence can be salvaged. As a more recently developed technique, porous polyethylene (PPE) ear reconstruction provides benefits when compared to rib techniques. Increasing surgeon awareness of complication management may lead to further adoption of the technique and improve reconstructive results. Described herein are two cases of draining infections following PPE ear reconstruction that were salvaged with satisfactory results. Laryngoscope, 2024
   This is the first description of Negative Pressure Wound Therapy (NPWT) use in rescuing alloplastic ear reconstructions. Previously considered a sign of certain impending failure, severe infections with frank purulence can be salvaged. As a more recently developed technique, porous polyethylene (PPE) ear reconstruction provides benefits when compared to rib techniques. Increasing surgeon awareness of complication management may lead to further adoption of the technique and improve reconstructive results. image
C1 [Gomez, Gabriel; Osterbauer, Beth; Arom, Gabriel; Kochhar, Amit] Childrens Hosp Los Angeles, Div Otolaryngol Head & Neck Surg, Los Angeles, CA USA.
   [Sie, Kathleen C. Y.] Seattle Childrens, Div Otolaryngol Head & Neck Surg, Seattle, WA USA.
   [Gomez, Gabriel] Childrens Hosp Los Angeles, Div Otolaryngol Head & Neck Surg, 4650 Sunset Blvd MS58, Los Angeles, CA 90027 USA.
C3 Children's Hospital Los Angeles; Seattle Children's Hospital; Children's
   Hospital Los Angeles
RP Gomez, G (通讯作者)，Childrens Hosp Los Angeles, Div Otolaryngol Head & Neck Surg, 4650 Sunset Blvd MS58, Los Angeles, CA 90027 USA.
EM ggomez@chla.usc.edu
CR Lewin S, 2015, FACIAL PLAST SURG, V31, P617, DOI 10.1055/s-0035-1567890
   Mir A, 2019, LARYNGOSCOPE, V129, P671, DOI 10.1002/lary.27262
   Sasaki K, 2021, J PLAST RECONSTR AES, V74, P1380, DOI 10.1016/j.bjps.2020.11.010
   Stephan S, 2018, FACIAL PLAST SURG CL, V26, P69, DOI 10.1016/j.fsc.2017.09.009
   TANZER R C, 1959, Plast Reconstr Surg Transplant Bull, V23, P1
NR 5
TC 2
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD SEP
PY 2024
VL 134
IS 9
BP 4122
EP 4125
DI 10.1002/lary.31403
EA MAR 2024
PG 4
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA A9C2D
UT WOS:001187610600001
PM 38506413
DA 2026-07-24
ER
PT J
AU Chen, PM
   Vilorio, NC
   Dhatariya, K
   Jeffcoate, W
   Lobmann, R
   Mcintosh, C
   Piaggesi, A
   Steinberg, J
   Vas, P
   Viswanathan, V
   Wu, SPN
   Game, F
AF Chen, Pam
   Vilorio, Nalini Campillo
   Dhatariya, Ketan
   Jeffcoate, William
   Lobmann, Ralf
   Mcintosh, Caroline
   Piaggesi, Alberto
   Steinberg, John
   Vas, Prash
   Viswanathan, Vijay
   Wu, Stephanie
   Game, Fran
TI Effectiveness of interventions to enhance healing of chronic foot ulcers
   in diabetes: A systematic review
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE diabetic foot; systematic review; wound healing
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; RANDOMIZED
   CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; PLATELET-RICH PLASMA;
   QUALITY-OF-LIFE; CONTROLLED CLINICAL-TRIAL; COLONY-STIMULATING FACTOR;
   EPIDERMAL-GROWTH-FACTOR; PLACEBO-CONTROLLED TRIAL
AB BackgroundIt is critical that interventions used to enhance the healing of chronic foot ulcers in diabetes are backed by high-quality evidence and cost-effectiveness. In previous years, the systematic review accompanying guidelines published by the International Working Group of the Diabetic Foot performed 4-yearly updates of previous searches, including trials of prospective, cross-sectional and case-control design.AimsDue to a need to re-evaluate older studies against newer standards of reporting and assessment of risk of bias, we performed a whole new search from conception, but limiting studies to randomised control trials only.Materials and MethodsFor this systematic review, we searched PubMed, Scopus and Web of Science databases for published studies on randomised control trials of interventions to enhance healing of diabetes-related foot ulcers. We only included trials comparing interventions to standard of care. Two independent reviewers selected articles for inclusion and assessed relevant outcomes as well as methodological quality.ResultsThe literature search identified 22,250 articles, of which 262 were selected for full text review across 10 categories of interventions. Overall, the certainty of evidence for a majority of wound healing interventions was low or very low, with moderate evidence existing for two interventions (sucrose-octasulfate and leucocyte, platelet and fibrin patch) and low quality evidence for a further four (hyperbaric oxygen, topical oxygen, placental derived products and negative pressure wound therapy). The majority of interventions had insufficient evidence.ConclusionOverall, the evidence to support any other intervention to enhance wound healing is lacking and further high-quality randomised control trials are encouraged.
C1 [Chen, Pam] Ramsay Healthcare Australia, Joondalup Hlth Campus, Joondalup, WA, Australia.
   [Chen, Pam] Univ Tasmania, Fac Hlth, Hobart, Tas, Australia.
   [Vilorio, Nalini Campillo] Plaza Salud Gen Hosp, Dept Diabetol, Diabetic Foot Unit, Santo Domingo, Dominican Rep.
   [Dhatariya, Ketan] Norfolk & Norwich Univ Hosp NHS Fdn Trust, Elsie Bertram Diabet Ctr, Norwich, England.
   [Dhatariya, Ketan] Univ East Anglia, Norwich Med Sch, Norwich, England.
   [Jeffcoate, William; Lobmann, Ralf] Klinikum Stuttgart, Clin Endocrinol Diabetol & Geriatr, Stuttgart, Germany.
   [Mcintosh, Caroline] Univ Galway, Sch Hlth Sci, Galway, Ireland.
   [Piaggesi, Alberto] Univ Pisa, Dept Med, Diabetic Foot Sect, Pisa, Italy.
   [Steinberg, John] Georgetown Univ, Sch Med, Washington, DC USA.
   [Vas, Prash] Kings Coll Hosp NHS Fdn Trust, London, England.
   [Viswanathan, Vijay] MV Hosp Diabet & M Prof Viswanathan Diabet Res Ctr, Chennai, India.
   [Wu, Stephanie] Rosalind Franklin Univ Med & Sci, Dr William M Scholl Coll Podiatr Med, N Chicago, IL USA.
   [Game, Fran] Univ Hosp Derby, Burton NHS Fdn Trust, Derby, England.
C3 University of Tasmania; Norfolk & Norwich University Hospitals NHS
   Foundation Trust; University of East Anglia; University of Stuttgart;
   University Stuttgart Hospital; Ollscoil na Gaillimhe-University of
   Galway; University of Pisa; Georgetown University; King's College
   Hospital NHS Foundation Trust; Rosalind Franklin University of Medicine
   & Science
RP Chen, PM (通讯作者)，Ramsay Healthcare Australia, Joondalup Hlth Campus, Joondalup, WA, Australia.; Chen, PM (通讯作者)，Univ Tasmania, Fac Hlth, Hobart, Tas, Australia.
EM chenp@ramsayhealth.com.au
OI Campillo-Vilorio, Nalini/0009-0009-8521-4262; Jeffcoate,
   William/0000-0002-1744-7576; McIntosh, Caroline/0000-0003-1801-9554;
   Game, Frances/0000-0002-5294-4789
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NR 278
TC 16
Z9 26
U1 2
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAR 20
PY 2024
VL 40
IS 3
AR e3786
DI 10.1002/dmrr.3786
PG 44
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LO7B4
UT WOS:001187798700001
PM 38507616
OA hybrid
DA 2026-07-24
ER
PT J
AU Seternes, A
   Rekstad, LC
   Lossius, W
   Wasmuth, HH
AF Seternes, Arne
   Rekstad, Lars Cato
   Lossius, William
   Wasmuth, Hans H.
TI A method for treatment of deep and superficial enteroatmospheric
   fistulas in an open abdomen, ChimneyVAC: Ten years experience
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
DE enteric leak; enteroatmospheric fistula; enterocutaneous fistula;
   negative pressure wound therapy; open abdomen
ID MANAGEMENT; CLASSIFICATION
AB BackgroundLeakage of intestinal fluid is a challenging event when it appears in an open abdomen (OA) and surgical deviation does not seem possible. Intestinal contents in the abdominal cavity maintain inflammation and drainage is there for essential. We have developed a method, ChimneyVAC, to treat both deep and superficial enteroatmospheric fistulas (EAF)AimsTo describe this innovative surgical technique and our 10-year experience.Material & MethodsThis single-center observational cohort study included all 16 consecutive patients treated with ChimneyVAC. Seven women and 9 men; median age: 47; (interquartile range [IQR]:39-63) years, 15 with a small bowel fistula and 1 with a large bowel fistula. All except of the colonic fistula were classified as a high output fistula; 14 were deep and 2 superficial. In this technique, a negative-pressure source is applied directly above the fistula opening, in addition to negative pressure wound therapy for the OA. This controls the leakage of intestinal fluid by direct drainage into a vacuum system, thereby avoiding contamination of the abdomen. A controlled enterocutaneous fistula (ECF) then forms as the traction from the ChimneyVAC brings the fistula opening to skin level.ResultsIn 14 patients, an ECF formed after a median of 42 (IQR:28-55) days and 12 (IQR:7-16) dressing changes. The median length of hospitalization was 103 (IQR:58-143) days. Two patients died of multiorgan failure and 14 initially survived.DiscussionThis study showed that 14 out of 16 patients survived the initial treatment for enteric leakage with the ChimneyVAC method. The outcome of ChimneyVAC treatment is a controlled ECF, which was then corrected after a median of six months. However, hospitalization is lengthy, the patients undergo several dressing changes and many needs additional parenteral nutrition until intestinal continuity is reestablished.ConclusionChimneyVAC is a feasible method for treatment of EAF in an OA, with favorable survival.
C1 [Seternes, Arne] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Surg, Sect Vasc Surg, Trondheim, Norway.
   [Seternes, Arne] Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, Trondheim, Norway.
   [Seternes, Arne] Trondheim Reg & Univ Hosp, St Olavs Hosp, Norwegian Res Ctr Minimally Invas & Image Guided D, Trondheim, Norway.
   [Rekstad, Lars Cato; Lossius, William; Wasmuth, Hans H.] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Surg, Sect Gastrointestinal Surg, Trondheim, Norway.
   [Seternes, Arne] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Surg, Sect Vasc Surg, PB 3250, N-7006 Trondheim, Norway.
C3 Norwegian University of Science & Technology (NTNU); Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU); Norwegian University of Science &
   Technology (NTNU); Norwegian University of Science & Technology (NTNU)
RP Seternes, A (通讯作者)，Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Surg, Sect Vasc Surg, PB 3250, N-7006 Trondheim, Norway.
EM Arne.Seternes@ntnu.no
OI Wasmuth, Hans Henrik/0000-0002-1936-6868; Lossius,
   William/0000-0003-0569-4104
CR Björck M, 2016, SCAND J SURG, V105, P5, DOI 10.1177/1457496916631853
   Di Saverio S, 2016, LANGENBECK ARCH SURG, V401, P1, DOI 10.1007/s00423-015-1370-3
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   Tavusbay C, 2015, SURG TODAY, V45, P1102, DOI 10.1007/s00595-014-1020-3
NR 5
TC 2
Z9 3
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD MAY
PY 2024
VL 48
IS 5
BP 1066
EP 1074
DI 10.1002/wjs.12156
EA MAR 2024
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QM5V1
UT WOS:001189370800001
PM 38520633
OA hybrid
DA 2026-07-24
ER
PT J
AU Tiang, T
   Behrenbruch, C
   Noori, J
   Lam, D
   Bhamidipaty, M
   Johnston, M
   Woods, R
   D'Souza, B
AF Tiang, Thomas
   Behrenbruch, Corina
   Noori, Jawed
   Lam, David
   Bhamidipaty, Madhu
   Johnston, Michael
   Woods, Rodney
   D'Souza, Basil
TI Prophylactic negative pressure wound therapy to improve wound healing
   rates following ileostomy closure: a randomized controlled trial
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE ileostomy reversal; negative pressure wound therapy; stoma closure
ID SURGICAL SITE INFECTION; STOMA REVERSAL; PURSESTRING CLOSURE;
   ANASTOMOTIC LEAKAGE; METAANALYSIS; CANCER
AB BackgroundReversal of ileostomy is associated with morbidity including wound infection and prolonged wound healing. Negative pressure wound therapy (NPWT) has been shown to reduce time to wound healing by secondary intention. The aim of this study was to determine whether NPWT improved wound healing rates, compared with simple wound dressings, in patients undergoing reversal of ileostomy where the skin wound is closed with a purse-string suture.MethodsThis was a dual-centre, open-label, randomized controlled trial with two parallel intervention arms. Patients undergoing elective loop ileostomy reversal were randomized 1:1 to receive NPWT or simple wound dressings. The primary endpoint of the study was assessment of complete wound healing at day 42 post reversal of ileostomy and the secondary endpoints were patient-reported wound cosmesis using a visual analogue scale and rates of surgical site infection (SSI).ResultsThe study was conducted from June 2018 to December 2021. The trial was approved by the local ethics committee. We enrolled 40 patients, 20 in each arm. One patient in each arm was lost to follow up. Nine patients (9/19, 47.36%) in the simple dressing group had wound healing vs. 13 patients (13/19, 68.42%) in the NPWT group (P = 0.188). There was no significant difference in patient- reported wound cosmesis or SSI.ConclusionThere was no difference in wound healing rates when comparing NPWT to simple wound dressings at early and late time points post reversal of ileostomy, where the skin wound was closed with a purse-string suture.
   Reversal of ileostomy is associated with morbidity including wound infection and prolonged wound healing. Negative pressure wound therapy (NPWT) has been shown to reduce time to wound healing by secondary intention. The aim of this study was to determine whether NPWT improves wound healing compared with simple wound dressings in patients following ileostomy closure. We found no significant difference in wound healing rates when comparing NPWT to simple wound dressings at early and late time points post reversal of stoma. image
C1 [Tiang, Thomas; Behrenbruch, Corina; Noori, Jawed; Lam, David; Bhamidipaty, Madhu; Johnston, Michael; Woods, Rodney; D'Souza, Basil] St Vincents Hosp Melbourne, Dept Colorectal Surg, Fitzroy, Vic, Australia.
   [Behrenbruch, Corina] Univ Melbourne, Dept Clin Educ, Melbourne, Vic, Australia.
   [Behrenbruch, Corina] St Vincents Hosp Melbourne, Dept Colorectal Surg, Level 2-41 Victoria Parade, Fitzroy, Vic 3065, Australia.
C3 St Vincent's Health; St Vincent's Hospital Melbourne; University of
   Melbourne; St Vincent's Health; St Vincent's Hospital Melbourne
RP Behrenbruch, C (通讯作者)，St Vincents Hosp Melbourne, Dept Colorectal Surg, Level 2-41 Victoria Parade, Fitzroy, Vic 3065, Australia.
EM cori.behrenbruch@gmail.com
RI ; Bhamidipaty, Madhu/GPF-4906-2022
OI Noori, Jawed/0009-0001-0910-7803; 
FU Wounds Australia; University of Melbourne, as part of the Wiley - The
   University of Melbourne agreement via the Council of Australian
   University Librarians
FX Open access publishing facilitated by The University of Melbourne, as
   part of the Wiley - The University of Melbourne agreement via the
   Council of Australian University Librarians.
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NR 25
TC 10
Z9 10
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD SEP
PY 2024
VL 94
IS 9
BP 1627
EP 1633
DI 10.1111/ans.18941
EA MAR 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA H2O3V
UT WOS:001189950300001
PM 38525845
OA hybrid
DA 2026-07-24
ER
PT J
AU Murray, W
   Davey, MG
   Robb, W
   Donlon, NE
AF Murray, William
   Davey, Mathew G.
   Robb, William
   Donlon, Noel E.
TI Management of esophageal anastomotic leaks, a systematic review and
   network meta-analysis
SO DISEASES OF THE ESOPHAGUS
LA English
DT Review
DE Esophagus; SEMS; EVAC; anastomotic leak
ID VACUUM-ASSISTED CLOSURE; THERAPY; STENT; COMPLICATIONS; PERFORATIONS;
   EFFICACY
AB There is currently no consensus as to how to manage esophageal anastomotic leaks. Intervention with endoscopic vacuum-assisted closure (EVAC), stenting, reoperation, and conservative management have all been mooted as potential options. To conduct a systematic review and network meta-analysis (NMA) to evaluate the optimal management strategy for esophageal anastomotic leaks. A systematic review was performed as per the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines with extension for NMA. NMA was performed using R packages and Shiny. In total, 12 retrospective studies were included, which included 511 patients. Of the 449 patients for whom data regarding sex was available, 371 (82.6%) were male, 78 (17.4%) were female. The average age of patients was 62.6 years (standard deviation 10.2). The stenting cohort included 245 (47.9%) patients. The EVAC cohort included 123 (24.1%) patients. The conservative cohort included 87 (17.0%) patients. The reoperation cohort included 56 (10.9%) patients. EVAC had a significantly decreased complication rate compared to stenting (odds ratio 0.23 95%, confidence interval [CI] 0.09;0.58). EVAC had a significantly lower mortality rate than stenting (odds ratio 0.43, 95% CI 0.21; 0.87). Reoperation was used in significantly larger leaks than stenting (mean difference 14.66, 95% CI 4.61;24.70). The growing use of EVAC as a first-line intervention in esophageal anastomotic leaks should continue given its proven effectiveness and significant reduction in both complication and mortality rates. Surgical management is often necessary for significantly larger leaks and will likely remain an effective option in uncontained leaks with systemic features.
C1 [Murray, William; Davey, Mathew G.; Robb, William; Donlon, Noel E.] Beaumont Hosp, Dept Upper Gastrointestinal Surg, Dublin, Ireland.
   [Murray, William] Monaire Lower Shelbourne Rd, Limerick V94A6NT, Ireland.
C3 Beaumont Hospital Dublin
RP Murray, W (通讯作者)，Monaire Lower Shelbourne Rd, Limerick V94A6NT, Ireland.
EM 10murrayw@gmail.com; mattgdavey1@gmail.com; robb.will@gmail.com;
   donlonn@tcd.ie
OI Donlon, Noel/0000-0002-4073-3896; Murray, William/0000-0001-5726-710X
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NR 55
TC 9
Z9 9
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1120-8694
EI 1442-2050
J9 DIS ESOPHAGUS
JI Dis. Esophagus
PD MAR 24
PY 2024
VL 37
IS 7
DI 10.1093/dote/doae019
EA MAR 2024
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA XK2C2
UT WOS:001190013400001
PM 38525940
DA 2026-07-24
ER
PT J
AU Keenan, C
   Obaidi, N
   Neelon, J
   Yau, I
   Carlsson, AH
   Nuutila, K
AF Keenan, Corey
   Obaidi, Noor
   Neelon, Jamie
   Yau, Irene
   Carlsson, Anders H.
   Nuutila, Kristo
TI Negative Pressure Wound Therapy: Challenges, Novel Techniques, and
   Future Perspectives
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; wound healing; vacuum-assisted closure
ID OPEN CELL FOAM; VACUUM-ASSISTED CLOSURE; DWELL TIME; INSTILLATION;
   IRRIGATION; MANAGEMENT; DRESSINGS; ADHERENCE; GAUZE; MESH
AB Significance: Negative pressure wound therapy (NPWT) has been in practice for decades, proving its utility in many applications, ranging from acutely infected wounds to complex combat wounds and skin grafting. It has been routinely demonstrated that NPWT has superior wound healing outcomes compared with previous standard-of-care therapies. However, the technique involves some challenges related to each of the components that comprise the therapy. The purpose of this article is to highlight the challenges, introduce the recent advancements, and discuss about the future directions in NPWT systems.Recent Advances: New techniques and materials have been developed to improve the currently used NPWT systems with promising results when utilized with appropriate indications. Many advancements have been introduced in modes of negative pressure delivery, pumps, interface dressings, adhesive dressings, and tubing technology.Critical Issues: An optimal NPWT system would avoid the common problems such as failure to deliver negative pressure due to loss of an airtight seal or tissue ingrowth into the interface dressing causing painful dressing changes and bleeding. Other challenges include infection control and patient pain and discomfort that may contribute to noncompliance.Future Directions: Many studies have been performed to evaluate the optimal combination of settings and components in various wounds; however, there is still no clear "best" answer for many specific patient-wound scenarios. Novel and emerging tissue engineering and regenerative medicine approaches could potentially be utilized in the future NPWT systems and thus, this review will discuss some novel ideas for future considerations.
C1 [Keenan, Corey; Yau, Irene] William Beaumont Army Med Ctr, Dept Surg, El Paso, TX USA.
   [Obaidi, Noor; Carlsson, Anders H.] Metis Fdn, San Antonio, TX USA.
   [Neelon, Jamie] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX USA.
   [Nuutila, Kristo] US Army Inst Surg Res, Ft Sam Houston, TX USA.
   [Nuutila, Kristo] US Army Inst Surg Res, 3698 Chambers Pass,Ste B JBSA, Ft Sam Houston, TX 78234 USA.
C3 William Beaumont Army Medical Center; Brooke Army Medical Center; United
   States Department of Defense; United States Army; United States
   Department of Defense; United States Army; United States Department of
   Defense; United States Army
RP Nuutila, K (通讯作者)，US Army Inst Surg Res, 3698 Chambers Pass,Ste B JBSA, Ft Sam Houston, TX 78234 USA.
EM kristo.nuutila@gmail.com
OI Carlsson, Anders/0000-0002-4846-108X; Keenan, Corey/0009-0005-6878-087X
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NR 101
TC 26
Z9 28
U1 4
U2 19
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JAN 1
PY 2025
VL 14
IS 1
BP 33
EP 47
DI 10.1089/wound.2023.0157
EA MAR 2024
PG 15
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA S5U4F
UT WOS:001191339200001
PM 38441029
OA Bronze
DA 2026-07-24
ER
PT J
AU Yang, CL
   Wang, DL
AF Yang, Chenglan
   Wang, Dali
TI Antibiotic bone cement accelerates diabetic foot wound healing:
   Elucidating the role of ROCK1 protein expression
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE antibiotic bone cement; diabetic foot; negative pressure wound therapy;
   ROCK1; wound healing
ID INDUCED MEMBRANE; RHO-KINASE; ULCERS; THERAPY; MASQUELET; DISEASE; CELL
AB Clinical studies indicate antibiotic bone cement with propeller flaps improves diabetic foot wound repair and reduces amputation rates, but the molecular mechanisms, particularly key proteins' role remain largely unexplored. This study assessed the efficacy of antibiotic bone cement for treating diabetic foot wounds, focusing on molecular impact on ROCK1. Sixty patients were randomized into experimental (EXP, n = 40) and control (CON, n = 20) groups, treated with antibiotic bone cement and negative pressure. Wound healing rate, amputation rate, wound secretion culture and C-reactive protein (CRP) changes, were monitored. Comprehensive molecular investigations were conducted and animal experiments were performed to further validate the findings. Statistical methods were employed to verify significant differences between the groups and treatment outcomes. The EXP group showed significant improvements in wound healing (chi(2)= 11.265, p = 0.004) and reduced amputation rates. Elevated levels of ROCK1, fibroblasts and VGF were observed in the trauma tissue post-treatment in the experimental group compared to pre-treatment and the control group (all p < 0.05). Improved trauma secretion culture and CRP were also noted in the EXP group (all p < 0.05). The study suggests that antibiotic bone cement enhances diabetic foot wound healing, possibly via upregulation of ROCK1. Further research is needed to elucidate the underlying molecular mechanisms and broader clinical implications.
C1 [Yang, Chenglan] Soochow Univ, Sch Med, Suzhou, Jiangsu, Peoples R China.
   [Wang, Dali] Zunyi Med Univ, Dept Burn Plast Surg, Affiliated Hosp, Zunyi 563000, Guizhou, Peoples R China.
C3 Soochow University - China; Zunyi Medical University
RP Wang, DL (通讯作者)，Zunyi Med Univ, Dept Burn Plast Surg, Affiliated Hosp, Zunyi 563000, Guizhou, Peoples R China.
EM daliwangzy@sina.com
FU Collaborative Innovation Center of Chinese Ministry of Education
FX We extend our deepest gratitude towards our colleagues who have
   contributed to this work and Papergoing institution for their
   contribution in manuscript polishing.
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NR 36
TC 7
Z9 8
U1 2
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR 26
PY 2024
VL 21
IS 4
AR e14590
DI 10.1111/iwj.14590
PG 16
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA MF2O7
UT WOS:001192148600001
PM 38531354
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tang, L
   Guo, ZY
   Zhao, Q
   Fan, X
   Pu, YJ
   He, B
   Chen, JL
AF Tang, Lei
   Guo, Zhaoyuan
   Zhao, Quan
   Fan, Xi
   Pu, Yuji
   He, Bin
   Chen, Jianlin
TI A Biodegradable Janus Sponge for Negative Pressure Wound Therapy
SO BIOMACROMOLECULES
LA English
DT Article
ID PEG-PLLA MICROPARTICLES; NPWT; SURGERY
AB Negative pressure wound therapy (NPWT) is effective in repairing serious skin injury. The dressing used in the NPWT is important for wound healing. In this paper, we develop biodegradable amphiphilic polyurethanes (PUs) and fabricate the PUs into sponges as wound dressings (Bi-@e) with Janus pore architectures for NPWT. The Bi-@e is adaptive to all the stages of the wound healing process. The Janus Bi-@e sponge consists of two layers: the dense hydrophobic upper layer with small pores provides protection and support during negative pressure drainage, and the loose hydrophilic lower layer with large pores absorbs large amounts of wound exudate and maintains a moist environment. Additionally, antibacterial agent silver sulfadiazine (SSD) is loaded into the sponge against Escherichia coli and Staphylococcus aureus with a concentration of 0.50 wt%. The Janus sponge exhibits a super absorbent capacity of 19.53 times its own water weight and remarkable resistance to compression. In a rat skin defect model, the Janus Bi-@e sponge not only prevents the conglutination between regenerative skin and dressing but also accelerates wound healing compared to commercially available NPWT dressing. The Janus Bi-@e sponge is a promising dressing for the NPWT.
C1 [Tang, Lei; Guo, Zhaoyuan; Zhao, Quan; Fan, Xi; Pu, Yuji; He, Bin] Sichuan Univ, Coll Biomed Engn, Natl Engn Res Ctr Biomat, Chengdu 610065, Peoples R China.
   [Guo, Zhaoyuan] Ningbo Baoting Biotech Co Ltd, Ningbo 315010, Peoples R China.
   [Chen, Jianlin] Chengdu Med Coll, Sch Lab Med, Sichuan Prov Engn Lab Prevent & Control Technol Ve, Chengdu 610500, Peoples R China.
C3 Sichuan University; Chengdu Medical College
RP He, B (通讯作者)，Sichuan Univ, Coll Biomed Engn, Natl Engn Res Ctr Biomat, Chengdu 610065, Peoples R China.; Chen, JL (通讯作者)，Chengdu Med Coll, Sch Lab Med, Sichuan Prov Engn Lab Prevent & Control Technol Ve, Chengdu 610500, Peoples R China.
EM bhe@scu.edu.cn; chenjianlin@cmc.edu.cn
RI Guo, Zhaoyuan/MGA-0255-2025; He, Bin/B-3257-2015; Pu, Yuji/J-3168-2019
OI He, Bin/0000-0002-0939-9869; Pu, Yuji/0000-0002-4465-0262
FU National Natural Science Foundation of China [51903172, 51773130];
   National Natural Science Foundation of China
FX We would like to thank the financial support by the National Natural
   Science Foundation of China (51903172 and 51773130). We thank the
   Analytical & Testing Center of Sichuan University for FT-IR (Dr Yani
   Xie) work.
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NR 41
TC 14
Z9 17
U1 12
U2 54
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1525-7797
EI 1526-4602
J9 BIOMACROMOLECULES
JI Biomacromolecules
PD MAR 28
PY 2024
VL 25
IS 4
BP 2542
EP 2553
DI 10.1021/acs.biomac.4c00046
EA MAR 2024
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA NL6J2
UT WOS:001193696000001
PM 38547378
DA 2026-07-24
ER
PT J
AU Albassam, KM
   Kachwala, AI
   Alharbi, OM
AF Albassam, Khaled M.
   Kachwala, Aliasgar I.
   Alharbi, Obaid M.
TI Successful treatment of a rare retroperitoneal necrotizing soft tissue
   infection due to cranial spread of necrotizing perianal infection in
   COVID positive patient: a case report
SO KUWAIT MEDICAL JOURNAL
LA English
DT Article
DE necrotizing soft tissue infections; negative pressure wound therapy;
   retroperitoneal
ID FASCIITIS; DIAGNOSIS; MANAGEMENT; MORTALITY
AB Retroperitoneal necrotizing soft tissue infections (NSTI) are rare and a lethal disease. Delay in diagnosis and initiating treatment can lead to disastrous outcomes.
   This is a case of a 38-year-old young COVID positive male with retroperitoneal NSTI possibly due to cranial spread of ischiorectal necrotizing infection by E.coli, Salmonella enterica and bacteroides. On presentation, patient had high grade fever with left flank pain for three days and perianal discomfort for 10 days. Laboratory evaluation of unexplained sepsis revealed leucocytosis and acute kidney injury. Emergency computerized tomography scan of the abdomen showed gas in soft tissue, tracking along left psoas muscle. Initial emergency perianal debridement for source control relieved sepsis, but not abdominal pain. After initial improvement, patient deteriorated again. Further serial debridements by lumbotomy without contaminating peritoneal cavity lead to improvement. Wound closure was achieved by negative pressure wound therapy (NPWT) and secondary closure.
   Ischiorectal infection can spread to retroperitoneum, even in the absence of any definite fistulous connections. Once in preperitoneal space, it can spread rapidly to retroperitoneum and can cause profound sepsis. Early diagnosis, broad spectrum antibiotics and thorough debridement with adequate wound drainage can be lifesaving. NPWT can be very useful in patients with extensive wounds in COVID positive patients.
C1 [Albassam, Khaled M.; Kachwala, Aliasgar I.; Alharbi, Obaid M.] Farwaniya Hosp, Dept Gen Surg, Kuwait, Kuwait.
   [Alharbi, Obaid M.] KIMS, Kuwait, Kuwait.
RP Kachwala, AI (通讯作者)，Farwaniya Hosp, Dept Gen Surg, Kuwait, Kuwait.
EM dr.aliasgar@yahoo.co.in
RI Kachwala, Alimohammed/LFS-1550-2024
CR Amitai A, 2008, J EMERG MED, V34, P37, DOI 10.1016/j.jemermed.2007.03.048
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU KUWAIT MEDICAL ASSOC
PI SAFAT
PA PO BOX 1202, SAFAT, 13013, KUWAIT
SN 1607-8047
EI 0023-5776
J9 KUWAIT MED J
JI Kuwait Med. J.
PD DEC
PY 2023
VL 55
IS 4
BP 354
EP 358
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MM8J7
UT WOS:001194126900011
DA 2026-07-24
ER
PT J
AU Marangi, GF
   Mirra, C
   Gratteri, M
   Cogliandro, A
   Salzillo, R
   Segreto, F
   Federico, G
   Romano, FD
   Rossi, C
   Persichetti, P
AF Marangi, Giovanni Francesco
   Mirra, Carlo
   Gratteri, Marco
   Cogliandro, Annalisa
   Salzillo, Rosa
   Segreto, Francesco
   Federico, Gaetano
   Romano, Fara Desiree
   Rossi, Caterina
   Persichetti, Paolo
TI Switching from Galenic to Advanced Dressings or Vacuum Assisted Closure
   Therapy Can Improve Quality of Life of Patients with Chronic
   Non-Responsive Pressure Skin Ulcers: Preliminary Data with Italian
   Translation of WOUND-Q
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE chronic wounds; dressings; negative pressure; personalized health care
ID VALIDATION; DEFINITION
AB Objective: A few studies have focused on the quality of life (QoL) of patients with chronic non-responsive pressure skin ulcers. The aim of this study was to assess how correct treatment (advanced wound care [AWC] dressings alone or vacuum assisted closure [VAC] therapy alone) changes the QoL of these patients.
   Approach: One hundred six patients with chronic non-responsive pressure skin ulcers, who had previously used galenic dressings, applied without proper therapeutic indication, were included in this study. We administered the WOUND-Q, at time 0 and after 1 month of appropriate therapy, to assess patient-reported outcome measures. Group 1 consisted of 30 patients treated with advanced dressings, Group 2: 22 patients treated with VAC therapy, and Group 3: 30 patients continuing conventional galenic dressings (Control group). Statistical analysis allowed us to analyze QoL changes over time and to compare WOUND-Q Group 1 and 2 deltas with those of Group 3. The study followed the STROBE statement.
   Results and Innovation: In all the scales evaluated (Assessment, Drainage, Smell, Life impact, Psychological, Social, Sleep and Dressing), there were significant improvements in mean values for Groups 1 and 2. Kruskal-Wallis tests with Dunn's multiple-comparisons tests and Brown-Forsythe and Welch Analysis of Variance tests demonstrated significant differences between deltas of Group 1 and Group 2 compared with those of Group 3 for most scales analyzed.
   Conclusions: Administration of the WOUND-Q demonstrated that the application of advanced dressings alone or VAC therapy alone positively affects the QoL of patients with chronic nonresponsive pressure wounds, in comparison with galenic dressings alone. The WOUND-Q has been shown to be a valid tool in studying changes in QoL of these patients.
C1 [Marangi, Giovanni Francesco; Mirra, Carlo; Gratteri, Marco; Cogliandro, Annalisa; Salzillo, Rosa; Segreto, Francesco; Federico, Gaetano; Romano, Fara Desiree; Rossi, Caterina; Persichetti, Paolo] Campus Biomed Univ Hosp, Dept Plast Reconstruct & Aesthet Surg, I-00128 Rome, Italy.
C3 Fondazione Policlinico Universitario Campus Bio-Medico; University
   Campus Bio-Medico - Rome Italy
RP Gratteri, M (通讯作者)，Campus Biomed Univ Hosp, Dept Plast Reconstruct & Aesthet Surg, I-00128 Rome, Italy.
EM m.gratteri@unicampus.it
RI , Annalisa/ADW-5837-2022; Marangi, Giovanni/AAW-4723-2020; Salzillo,
   Rosa/HJB-3151-2022; Gratteri, Marco/KGM-5481-2024
OI Gratteri, Marco/0000-0001-7375-1524; Rossi, Caterina/0000-0001-9223-6413
CR aiuc, REPORT E ANALISI DEI DATI-Aiuc-Associazione Italiana Ulcere Cutanee Onlus
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   US
NR 43
TC 4
Z9 4
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAR 1
PY 2024
VL 13
IS 3
BP 131
EP 139
DI 10.1089/wound.2022.0150
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA MT1T7
UT WOS:001195802000001
PM 37551983
DA 2026-07-24
ER
PT J
AU Oshima, J
   Inoue, Y
   Sasaki, K
   Sekido, M
AF Oshima, Junya
   Inoue, Yoshiaki
   Sasaki, Kaoru
   Sekido, Mitsuru
TI Various Purposes of Negative Pressure Wound Therapy in Severe Burn
   Treatment: a Short Case Series Analysis
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Burn; Flap surgery; Negative pressure wound therapy; Skin graft
ID SKIN-GRAFT; DONOR SITE; RECONSTRUCTION; MANAGEMENT; FLAP
AB The purposes for performing negative pressure wound therapy (NPWT) in severe burns are diverse, but few reports comprehensively discussing its indications and methods have been published. We included patients with a >= 30% total burn area. There were 4 patients, and a total of 9 NPWT were performed. The therapy sites were the upper extremity (n = 2), the elbow (n = 1), the dorsum of the hand (n = 5), and the knee (n = 1). The purposes of the therapy were bridge-to-skin grafting (n = 5), dressing the artificial dermis (n = 1), therapy for bolstering the autograft (n = 1), bridge-to-flap surgery (n = 1), and covering the flap (n = 1). The devices used were bedside wall suction (n = 5) and dedicated device (n = 3). Therapy was converted to wall aspiration after use of the dedicated device in 1 case. NPWT is an effective option in severe burn treatment. For each purpose, it is necessary to consider the device used, negative pressure setting, starting date, frequency of dressing changes, and period of therapy. NPWT in severe burns also has the advantage of prioritizing life-prolonging treatment. If strict control of negative pressure is required, a dedicated device should be used rather than wall suction.
C1 [Oshima, Junya; Sasaki, Kaoru; Sekido, Mitsuru] Univ Tsukuba, Dept Plast Reconstruct & Hand Surg, Tsukuba, Ibaraki, Japan.
   [Inoue, Yoshiaki] Univ Tsukuba, Dept Emergency & Crit Care Med, Tsukuba, Ibaraki, Japan.
C3 University of Tsukuba; University of Tsukuba
RP Oshima, J (通讯作者)，Univ Tsukuba, Dept Plast Reconstruct & Hand Surg, Tsukuba, Ibaraki, Japan.
EM ooshima-tuk@umin.ac.jp
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   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   Van Rysselberghe NL, 2022, J ORTHOP TRAUMA, V36, pS6, DOI 10.1097/BOT.0000000000002430
   Yin YC, 2018, INT J SURG, V50, P43, DOI 10.1016/j.ijsu.2017.12.020
NR 24
TC 0
Z9 1
U1 0
U2 2
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD JUN
PY 2024
VL 86
IS 3
BP 554
EP 560
DI 10.1007/s12262-023-03902-0
EA AUG 2023
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A5G2I
UT WOS:001196181300001
DA 2026-07-24
ER
PT J
AU Lu, ZY
   Zhang, XX
   Huo, YX
   Zhang, SK
AF Lu, Ziyi
   Zhang, Xinxin
   Huo, Yixuan
   Zhang, Shoukai
TI A case of deep neck abscess treated with a disposable VSD wound care
   device: Case report and review of literature
SO MEDICINE
LA English
DT Article
DE deep neck abscess; treatment; vacuum sealing drainage
AB Rationale: Vacuum sealing drainage is a novel technique for wound treatment that is characterized by adequate drainage and promotes wound healing. We report a case in which negative pressure sealing drainage was applied to treat a deep cervical abscess and achieved a good therapeutic effect. Patient concerns: The abscess in the neck will go down. Diagnoses: Deep neck abscess. Interventions: The usual surgical approach to treating this condition is to make a small incision to incise and drain the patient infected area where it is most visibly swollen or fluctuating, and to place a negative pressure drainage device. Outcomes: Eleven days after the operation, the patient neck recovered well, there was no infection in the operation area, and the patient was discharged from the hospital with improved symptoms. Lessons: This proves that the negative pressure closed drainage technique has potential in the treatment of deep neck abscesses and is also an effective choice in promoting wound healing, which is expected to bring better therapeutic effects to patients treated for deep neck abscesses.
C1 [Lu, Ziyi; Zhang, Xinxin] Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China.
   [Huo, Yixuan] Ningxia Med Univ, Ningxia, Peoples R China.
   [Zhang, Shoukai] Gansu Prov Hosp, Dept Otolaryngol Head & Neck Surg, Lanzhou, Gansu, Peoples R China.
   [Zhang, Shoukai] Gansu Prov Hosp, Otolaryngol Head Neck Surg, Lanzhou 730000, Peoples R China.
C3 Gansu University of Chinese Medicine; Ningxia Medical University
RP Zhang, SK (通讯作者)，Gansu Prov Hosp, Otolaryngol Head Neck Surg, Lanzhou 730000, Peoples R China.
EM drluziyi@163.com; zhangshoukai1977@126.com; hyxluck0202z@163.com;
   zhangshoukai1977@126.com
OI lu, ziyi/0009-0002-9237-6314
FU Gansu Provincial Natural Fund [22JR5RA664]
FX Gansu Provincial Natural Fund: 22JR5RA664.
CR Chen BL, 2017, MEDICINE, V96, DOI [10.1097/MD.0000000000006511, 10.1097/md.0000000000006511]
   Fiorella ML, 2020, ACTA OTORHINOLARYNGO, V40, P332, DOI 10.14639/0392-100X-N0790
   Gu X, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000024367
   Hansen BW, 2020, SEMIN ULTRASOUND CT, V41, P74, DOI 10.1053/j.sult.2019.10.001
   Huang T., 2023, Medicine (Baltim), V102, pe32785
   Subspecialty Group of Head and Neck Surgery Editorial Board of Chinese Journal of Otorhinolaryngology Head, 2022, Chin J Otolaryngol Head Neck Surg, V57, P405
NR 6
TC 0
Z9 0
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAR 22
PY 2024
VL 103
IS 12
AR e37397
DI 10.1097/MD.0000000000037397
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MW6J1
UT WOS:001196708800065
PM 38518028
OA Green Published, gold
DA 2026-07-24
ER
PT J
AU Tulimieri, MT
   Callas, PW
   D'Oria, M
   Bertges, DJ
AF Tulimieri, Maxwell T.
   Callas, Peter W.
   D'Oria, Mario
   Bertges, Daniel J.
TI Effectiveness of Closed Incision Negative Pressure Wound Therapy for
   Infrainguinal Bypass in the Vascular Quality Initiative
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID REVASCULARIZATION; COMPLICATIONS; TRIAL
AB Background: To analyze surgical site infections (SSIs) after infrainguinal bypass for standard dressings versus closed incision negative pressure wound therapy (ciNPWT) in the Society for Vascular Surgery's Vascular Quality Initiative (VQI). Methods: We retrospectively analyzed SSI after infrainguinal bypass procedures in the VQI from December 2019 to December 2021 comparing ciNPWT and standard dressings. The primary outcome of any superficial or deep wound infection at 30 days was analyzed in a subset of procedures with 30 -day follow-up data (cohort A, n = 1,575). Secondary outcomes including in -hospital SSI, return to the operating room (OR) for infection, and length of stay (LOS) were analyzed for all procedures (cohort B, n = 9,288). Outcomes were analyzed in propensitymatched cohorts. Results: Patients who received ciNPWT (n = 1,389) were more likely to be female (34% vs. 32%, P = 0.04) with a higher rate of smoking history (90% vs. 86%, P = 0.003), diabetes (54% vs. 50%, P = 0.007), obesity (34% vs. 26%, P < 0.001), prior peripheral vascular intervention (57% vs. 51%, P < 0.001), and to prosthetic conduit (55% vs. 48%, P < 0.001) compared to patients with standard dressings (n = 7,899). After propensity matching of cohort A (n = 1,256), the 30 -day SSI rate was 4% (12/341) in the ciNPWT and 6% (54/896) in the standard dressing group (P = 0.07, 95% CI 0.03-1.06). In the propensity -matched in -hospital cohort B (n = 5,435), SSI was 3% (35/1,371) in the ciNPWT group and 2% (95/4,064) in the standard dressing group (P = 0.66). There was no difference in the rate of return to the OR for infection, 1% (36/4,064) vs. 1% (19/1,371) (P = 0.13) or LOS, 9.0 vs. 9.0 days (P = 0.86) for the standard versus ciNPWT groups. Conclusions: In this analysis of the VQI registry, the use of ciNPWT after infrainguinal bypass did not result in a statistically significant decrease in 30 -day SSI. We recommend that surgeons consider the use of ciNPWT as part of a bundled process of care for high risk rather than all patients, as it may reduce SSI after infrainguinal bypass.
C1 [Tulimieri, Maxwell T.] Univ Vermont, Larner Coll Med, Burlington, VT USA.
   [Callas, Peter W.] Univ Vermont, Med Biostat, Burlington, VT USA.
   [D'Oria, Mario] Univ Hosp Trieste, Cardiovasc Dept, Div Vasc & Endovascular Surg, Trieste, Italy.
   [Bertges, Daniel J.] Univ Vermont, Div Vasc Surg, Med Ctr, Burlington, VT USA.
   [Bertges, Daniel J.] Univ Vermont, Div Vasc Surg, Med Ctr, 111 Colchester Ave,Smith 338, Burlington, VT 05401 USA.
C3 University of Vermont; University of Vermont; University of Trieste;
   University Trieste Hospital; University of Vermont; University of
   Vermont Medical Center; University of Vermont Medical Center; University
   of Vermont
RP Bertges, DJ (通讯作者)，Univ Vermont, Div Vasc Surg, Med Ctr, 111 Colchester Ave,Smith 338, Burlington, VT 05401 USA.
EM daniel.bertges@uvmhealth.org
RI D'Oria, Mario/AAF-5578-2020
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
   [Anonymous], 2020, SVS VQI Procedures Collected, The Vascular Quality Initia- tive.
   Antoniou GA, 2019, J VASC SURG, V70, P1700, DOI 10.1016/j.jvs.2019.01.083
   Bertges DJ, 2021, J VASC SURG, V74, P257, DOI 10.1016/j.jvs.2020.12.100
   Borgquist O, 2011, WOUND REPAIR REGEN, V19, P727, DOI 10.1111/j.1524-475X.2011.00741.x
   Engelhardt M, 2018, INT WOUND J, V15, P327, DOI 10.1111/iwj.12848
   Fernandez LG, 2019, CUREUS J MED SCIENCE, V11, DOI 10.7759/cureus.5183
   Frisbie JJ, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9217
   Glass GE, 2014, BJS-BRIT J SURG, V101, P1627, DOI 10.1002/bjs.9636
   Gombert A, 2020, VASCULAR, V28, P274, DOI 10.1177/1708538119890960
   Gombert A, 2018, EUR J VASC ENDOVASC, V56, P442, DOI 10.1016/j.ejvs.2018.05.018
   Gurtner GC, 2008, NATURE, V453, P314, DOI 10.1038/nature07039
   Kwon J, 2018, J VASC SURG, V68, P1744, DOI 10.1016/j.jvs.2018.05.224
   Lee K, 2017, J VASC SURG, V66, P1814, DOI 10.1016/j.jvs.2017.06.084
   McGillicuddy EA, 2016, J VASC SURG, V64, P1780, DOI 10.1016/j.jvs.2016.05.068
   Meeker J, 2011, J ORTHOP TRAUMA, V25, P756, DOI 10.1097/BOT.0b013e318211363a
   Mirzaie AA, 2023, J VASC SURG, V77, P248, DOI 10.1016/j.jvs.2022.06.024
   Murphy P, 2015, TRIALS, V16, DOI 10.1186/s13063-015-1026-1
   Pherson MJ, 2022, J VASC SURG, V76, P1014, DOI 10.1016/j.jvs.2022.04.040
   Pleger SP, 2018, INT WOUND J, V15, P75, DOI 10.1111/iwj.12836
   Sabat J, 2016, J VASC SURG, V63, p94S, DOI 10.1016/j.jvs.2016.03.099
   Strobel RM, 2022, LANGENBECK ARCH SURG, V407, P819, DOI 10.1007/s00423-021-02346-y
   Svensson-Björk R, 2019, BJS-BRIT J SURG, V106, P310, DOI 10.1002/bjs.11100
   Wee IJY, 2019, EUR J VASC ENDOVASC, V58, P446, DOI 10.1016/j.ejvs.2018.12.021
   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
NR 25
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD MAY
PY 2024
VL 102
BP 47
EP 55
DI 10.1016/j.avsg.2023.11.050
EA FEB 2024
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA NA6W9
UT WOS:001197767300001
PM 38307232
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Rafaqat, W
   Zamudio, JAP
   Abiad, M
   Lagazzi, E
   Argandykov, D
   Luckhurst, CM
   Velmahos, GC
   DeWane, MP
   Kaafarani, HMA
   Hwabejire, JO
AF Rafaqat, Wardah
   Zamudio, Jefferson A. Proano
   Abiad, May
   Lagazzi, Emanuele
   Argandykov, Dias
   Luckhurst, Casey M.
   Velmahos, George C.
   DeWane, Michael P.
   Kaafarani, Haytham M. A.
   Hwabejire, John O.
TI Negative pressure wound therapy for emergency laparotomy incisions: A
   national database propensity matched study
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Negative pressure wound therapy; NPWT; Emergency; Laparotomy
ID SURGICAL SITE INFECTION; PREVENTION; CLOSURE
AB Background: Surgical site infections (SSI) are a common complication of laparotomy incisions. The role of Negative Pressure Wound Therapy (NPWT) in preventing SSIs has not yet been explored in a nationwide analysis. We aimed to evaluate the association of the prophylactic use of NPWT with SSIs in patients undergoing an emergency laparotomy procedure. Methods: We conducted a retrospective cohort study using the National Surgery Quality Initiative Program (NSQIP) database from 2013 to 2020. We included patients >= 18 years undergoing an emergency laparotomy. We performed a 1:1 propensity matching adjusting for patient age, sex, race, ethnicity, BMI, comorbid conditions, ASA status, diagnosis, preoperative factors and laboratory variables, procedure type, wound class, and intraoperative variables. We compared NPWT with standard dressings in two patient populations: 1. patients with completely closed (skin and fascia) laparotomy incisions and 2. patients with partially closed (fascia only) laparotomy incisions. Our primary outcome was the rate of incisional SSI. Secondary outcomes included the type of SSI, postoperative 30-day complications, postoperative hospital length of stay, and discharge disposition. Results: We included 65,803 patients with completely closed incisions of whom 387 patients received NPWT. There was no significant difference in the rate of total SSIs (13.4 % vs. 11.9 %; p = 0.52) in the matched population of 387 pairs. We included 7285 patients with partially closed incisions of whom 477 patients received NPWT. There was no significant difference in the rate of total SSIs (3.6 % vs. 4.4 %; p = 0.51) in the matched population of 477 pairs. Secondary outcomes did not differ significantly in either group. Conclusion: The rate of SSIs was not significantly different when prophylactic NPWT was used compared to standard dressings for patients with a closed or partially closed laparotomy incision.
C1 [Rafaqat, Wardah; Zamudio, Jefferson A. Proano; Abiad, May; Lagazzi, Emanuele; Argandykov, Dias; Luckhurst, Casey M.; Velmahos, George C.; DeWane, Michael P.; Kaafarani, Haytham M. A.; Hwabejire, John O.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Surg, Div Trauma Emergency Gen Surg & Surg Crit Care, Boston, MA USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Hwabejire, JO (通讯作者)，Massachusetts Gen Hosp, Div Trauma Emergency Surg & Surg Crit Care, 165 Cambridge St Suite 810, Boston, MA 02114 USA.
EM jhwabejire@mgb.org
RI Lagazzi, Emanuele/MDT-4749-2025; DeWane, Michael/JFB-6828-2023
OI Lagazzi, Emanuele/0000-0002-5696-9641; Hwabejire,
   John/0000-0003-0759-2638; Abiad, May/0000-0002-2257-7519; DeWane,
   Michael/0000-0002-7042-7400
CR Almansa-Saura S, 2021, SURG INFECT, V22, P854, DOI 10.1089/sur.2020.407
   American College of Surgeons, 2018, User guide for the 2017 ACS NSQIP participant use data file (PUF)
   American College of Surgeons, 2017, ACS NSQIP participant use data file
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   Henderson WG, 2009, AM J SURG, V198, pS19, DOI 10.1016/j.amjsurg.2009.07.025
   Javed AA, 2019, ANN SURG, V269, P1034, DOI 10.1097/SLA.0000000000003056
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   Lord A C, 2015, Ann R Coll Surg Engl, V97, pe3, DOI 10.1308/003588414X14055925059237
   Lozano-Balderas G, 2017, AM SURGEON, V83, P512
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   Mukhi AN, 2014, CAN J SURG, V57, P314, DOI 10.1503/cjs.026613
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   Papadopoulos A, 2021, IN VIVO, V35, P3569, DOI 10.21873/invivo.12660
   Ploegmakers IBM, 2017, BRIT J SURG, V104, pE24, DOI 10.1002/bjs.10426
   Sahebally SM, 2018, JAMA SURG, V153, DOI 10.1001/jamasurg.2018.3467
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NR 23
TC 3
Z9 3
U1 0
U2 1
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD FEB
PY 2024
VL 228
BP 287
EP 294
DI 10.1016/j.amjsurg.2023.10.055
EA FEB 2024
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NA7A7
UT WOS:001197771100001
PM 37981515
DA 2026-07-24
ER
PT J
AU James, K
   Glasswell, A
   Costa, B
AF James, Kelly
   Glasswell, Amy
   Costa, Ben
TI Single-use negative pressure wound therapy versus conventional dressings
   for the reduction of surgical site infections in closed surgical
   incisions: Systematic literature review and meta-analysis
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Review
DE Surgical site infection; Surgical site complication; General surgery;
   Single-use negative pressure wound therapy; Systematic literature
   review; Meta-analysis
ID CARE-ASSOCIATED INFECTIONS; RISK-FACTORS; PRIMARY HIP; SURGERY;
   PREVENTION; COSTS; TRIAL; ARTHROPLASTY; FRACTURES; CLOSURE
AB Background: To evaluate whether a single -use negative pressure wound therapy (sNPWT) device can reduce the incidence of surgical site infection (SSI) in at -risk patients with closed surgical incisions across a range of surgical specialties, compared with standard care. Methods: PubMed, Embase, Cochrane Library and ClinicalTrials.gov were searched from the period January 2011 to April 2021. Results: Out of 15,283 articles identified, 19 were included. A statistically significant improvement (p < 0.05) in the composite SSI (odds ratio [OR]: 0.36; 95 % confidence interval [CI]: 0.27-0.49), superficial SSI (OR: 0.30; 95 % CI: 0.17-0.53), and deep SSI (OR: 0.67; 95 % CI: 0.46-0.96) outcomes was observed with the sNPWT device compared with standard care in a pooled analysis of all surgical specialties. Conclusion: A -80 mmHg sNPWT device reduces the incidence of composite, superficial, and deep SSIs when compared with standard care across a heterogenous at -risk surgical population containing a variety of surgical specialties.
C1 [James, Kelly] United Surg Associates Kansas City, Gen Surg, Independence, MO USA.
   [Glasswell, Amy; Costa, Ben] Smith & Nephew, Global Clin & Med Affairs, Kingston Upon Hull, England.
   [Costa, Ben] Smith & Nephew, Global Clin & Med Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, England.
C3 Smith & Nephew; Smith & Nephew
RP Costa, B (通讯作者)，Smith & Nephew, Global Clin & Med Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, England.
EM onesurgn@yahoo.com; Amy.Glasswell@smith-nephew.com;
   Ben.Costa@smith-nephew.com
OI Glasswell, Amy/0000-0001-9158-5427; Costa, Benedict/0000-0002-7132-2520
FU Smith and Nephew Inc.
FX Funding This work was supported by Smith and Nephew Inc.
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NR 47
TC 14
Z9 16
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD FEB
PY 2024
VL 228
BP 70
EP 77
DI 10.1016/j.amjsurg.2023.10.031
EA FEB 2024
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NB8N5
UT WOS:001198076500001
PM 37903665
OA hybrid
DA 2026-07-24
ER
PT J
AU Cheng, CY
   Cheng, MH
   Yang, CY
   Wang, CH
   Lim, J
   Huang, W
   Lin, CH
AF Cheng, Chun-Yu
   Cheng, Ming-Huei
   Yang, Chin-Yu
   Wang, Cheng-Han
   Lim, Joshua
   Huang, Wei
   Lin, Chih-Hsin
TI The Effects of Negative Pressure Therapy on Hair Growth of Mouse Models
SO TISSUE ENGINEERING PART A
LA English
DT Article
DE negative pressure therapy; external tissue expansion device; hair
   growth; angiogenesis; nude mice
ID VACUUM-ASSISTED CLOSURE; FOLLICLE; SOX9; LHX2; MECHANISMS; EXPRESSION;
   HYPOXIA; PATTERN; WOUNDS; CELLS
AB Negative pressure therapy (NPT) has been shown to facilitate wound healing and promote hair growth in a porcine model. However, there is a paucity of research on the impact of negative pressure on hair growth in murine models. Despite the ability of nude mice to develop hair follicles, the hair they produce is often flawed towing to genetically induced keratin disorders, rendering them a pertinent animal model for assessing hair regeneration. Therefore, this study aims to investigate the effects of negative pressure on hair follicle growth in a nude mouse model. To achieve this, a customized external tissue expansion device was developed to apply negative pressure to the dorsum of nude mice. The mice were subjected to several treatment courses consisting of 15 and 30 min of continuous negative pressure at 10 mmHg, which were repeated 5 and 10 times every other day until sacrifice. Dorsal skin samples were subsequently extracted from the suction and nonsuction areas. The sections were stained with various antibodies to assess the expression of SOX-9, LHX-2, Keratin-15, beta-catenin, CD31, and vascular endothelial growth factor-A, and a TUNEL assay was used to analyze cell apoptosis. The results showed that the number of hair follicles and angiogenesis were significantly higher in the suction area than in the nonsuction area in all groups. Moreover, mice that received NPT for 15 min for 10 times had a higher hair follicle density than the other three groups. Immunofluorescence staining for LHX-2 and Keratin 15 further validated the results of these findings. In conclusion, this study demonstrated that negative pressure effectively promotes hair follicle growth and angiogenesis in nude mice through SOX-9- and LHX-2-mediated follicular regeneration and beta-catenin-mediated hair follicle morphogenesis.
   Impact Statement The results of this study indicate that negative pressure therapy (NPT) is effective in promoting hair growth in nude mice, as evidenced by increased hair follicle density and angiogenesis in the treated areas. Using a custom external tissue expansion device (ETED) device, 15-min NPT treatment conducted over 10 sessions demonstrated the highest follicle density. This suggest that developing a regimen for NPT may offer to create innovative treatment approaches for hair loss, ultimately benefiting individuals suffering from hair loss disorders.
C1 [Cheng, Chun-Yu; Cheng, Ming-Huei; Yang, Chin-Yu; Wang, Cheng-Han] Chang Gung Mem Hosp, Ctr Tissue Engn, Taoyuan, Taiwan.
   [Cheng, Chun-Yu] Chang Gung Mem Hosp, Dept Dermatol, Taoyuan, Taiwan.
   [Cheng, Ming-Huei] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Div Reconstruct Microsurg, Taoyuan, Taiwan.
   [Cheng, Ming-Huei] Univ Michigan, Sect Plast Surg, Ann Arbor, MI USA.
   [Lim, Joshua; Lin, Chih-Hsin] Taipei Med Univ, Coll Biomed Engn, Grad Inst Nanomed & Med Engn, Taipei, Taiwan.
   [Huang, Wei] Rutgers Sch Dent Med, Dept Orthodont, Newark, NJ USA.
   [Lin, Chih-Hsin] Taipei Med Univ, Grad Inst Nanomed & Med Engn, 301 Yuantong Rd, New Taipei 235, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   Memorial Hospital; University of Michigan System; University of
   Michigan; Taipei Medical University; Rutgers University System; Rutgers
   University New Brunswick; Rutgers University Biomedical & Health
   Sciences
RP Lin, CH (通讯作者)，Taipei Med Univ, Grad Inst Nanomed & Med Engn, 301 Yuantong Rd, New Taipei 235, Taiwan.
EM melodylin@tmu.edu.tw
OI Lin, Chih-Hsin/0000-0001-7381-5938
FU Chang Gung Memorial Hospital [CMRPG3L0121]; Ministry of Science and
   Technology [MOST110-2222-E-038-001-MY3]
FX This project was supported by Chang Gung Memorial Hospital funding
   (CMRPG3L0121) and the Ministry of Science and Technology funding
   (MOST110-2222-E-038-001-MY3).
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NR 39
TC 0
Z9 0
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD NOV 1
PY 2024
VL 30
IS 21-22
BP 712
EP 719
DI 10.1089/ten.tea.2024.0056
EA APR 2024
PG 8
WC Cell & Tissue Engineering; Cell Biology; Engineering, Biomedical;
   Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering; Materials Science
GA L3W9L
UT WOS:001198729500001
PM 38534878
DA 2026-07-24
ER
PT J
AU Serena, TE
   King, E
   Serena, L
   Breisinger, K
   Al-Jalodi, O
   Myntti, MF
AF Serena, Thomas E.
   King, Emily
   Serena, Laura
   Breisinger, Kristy
   Al-Jalodi, Omar
   Myntti, Matthew F.
TI A Diagnostic-Driven Prospective Clinical Study Evaluating the
   Combination of an Antibiofilm Agent and Negative Pressure Wound Therapy
SO DIAGNOSTICS
LA English
DT Article
DE pressure ulcers; biofilm; negative pressure wound therapy; pressure
   injuries; fluorescence imaging; wound healing
ID ULCERS; INSTILLATION; BIOFILMS
AB Background: Each year, millions of Americans develop truncal pressure ulcers (PUs) which can persist for months, years, or until the end of life. Despite the negative impact on quality of life and escalating costs associated with PUs, there is sparse evidence supporting validated and efficacious treatment options. As a result, treatment is based on opinion and extrapolation from other wound etiologies. The ideal reconstructive plan maximizes the patient's nutritional status, incorporates the basic tenets of wound bed preparation (debridement, offloading, proper moisture balance, reduction of bacterial burden), and employs diagnostics to guide therapeutic intervention. The use of combination therapies can potentially overcome several of the barriers to wound healing. Negative pressure wound therapy (NPWT), a commonly used modality in the management of PUs, facilitates healing by stimulating the formation of granulation tissue and promoting wound contraction; however, NPWT alone is not always effective. Clinical studies examining microbial bioburden in PUs determined that most ulcers contain bacteria at levels that impede wound healing (>10(4) CFU/g). Objective: Thus, we hypothesized that adding an anti-microbial agent to decrease both planktonic and biofilm bacteria in the wound would increase the efficacy of NPWT. Method: In this prospective study, twenty patients with recalcitrant PUs that previously failed NPWT were treated with a biofilm-disrupting agent (Blast-X, Next Science, Jacksonville, FL, USA) in combination with NPWT. Fluorescence imaging was used to follow bacterial burden and guide therapy. Results: In total, 45% of the PUs reduced in size over the course of the four-week study, with a resolution of bacterial fluorescence in the NPWT dressing and wound bed seen in an average of three weeks. Conclusion: The combination of an antibiofilm agent and NPWT reduced bacterial levels and improved wound healing in recalcitrant PUs.
C1 [Serena, Thomas E.; King, Emily; Serena, Laura; Breisinger, Kristy; Al-Jalodi, Omar] SerenaGroup Res Fdn, Cambridge, MA 02140 USA.
   [Myntti, Matthew F.] Next Sci LLC, Jacksonville, FL 32256 USA.
RP King, E (通讯作者)，SerenaGroup Res Fdn, Cambridge, MA 02140 USA.
EM eking@serenagroups.com; lserena@serenagroups.com;
   kbreisinger@serenagroups.com; omarhjalodi@gmail.com;
   mmyntti@nextscience.org
OI AL-JALODI, OMAR/0000-0003-3725-3784; Serena, Thomas/0000-0003-1032-3578
FU Next Science
FX No Statement Available
CR Ammons MCB, 2011, INT WOUND J, V8, P268, DOI 10.1111/j.1742-481X.2011.00781.x
   Andersen C.A., 2023, J. Wound Manag, V24, P80
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   Serena TE, 2016, WOUND REPAIR REGEN, V24, P589, DOI 10.1111/wrr.12431
   Sheehan P, 2003, DIABETES CARE, V26, P1879, DOI 10.2337/diacare.26.6.1879
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   Vellingiri K, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.10116
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   Wolcott R D, 2008, J Wound Care, V17, P145
NR 27
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD APR
PY 2024
VL 14
IS 7
AR 774
DI 10.3390/diagnostics14070774
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA NP4Z8
UT WOS:001201656000001
PM 38611687
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kasten, K
   Yang, A
   Shaffer, L
   Kociola, S
   Holland, C
   Roche, FA
   Pilbeam, C
AF Kasten, Kody
   Yang, Andrew
   Shaffer, Lynn
   Kociola, Samuel
   Holland, Conor
   Roche, Faith Anne
   Pilbeam, Calvin
TI Managing incisional wounds with Prevena VAC therapy in lower-extremity
   vascular surgery: A comparative study
SO VASCULAR
LA English
DT Article
DE Prevena; vascular surgery; wound vac; lower-extremity wounds;
   lower-extremity; vascular
ID SURGICAL SITE INFECTION; PRESSURE; RISK; AMPUTATION
AB Background: Vascular surgical site infections have been reported with an overall incidence of 5-10% for patients undergoing arterial interventions and as high as 10-20% for lower-limb bypass grafting procedures. Given that vascular surgery patients are known to be at a higher risk of postoperative wound infections and other complications, our objective was to evaluate a potential method to reduce such complications. This study compares the rate of wound healing complications between incisional negative pressure wound therapy (NPWT) and conventional dressings in vascular surgery patients with infra-inguinal incisions. The primary endpoint is complete closure of the wound at the 2-week follow-up appointment. Secondary endpoints include frequency infections requiring antibiotics, need for wound revision, and wound dehiscence. Methods: A prospective cohort study with retrospective control group was performed following infra-inguinal vascular surgeries for peripheral arterial disease at the Mount Carmel Health System. The patients included in this study were those who underwent a lower-extremity vascular procedure with primary closure of an incision distal to the groin between January 2014 and July 2018. Patients that had received an infra-inguinal incision with primary closure were included. Patients in the experimental group who had a Prevena Wound VAC were compared with a retrospectively obtained control arm treated with conventional dressings. Data regarding wound healing and complications, specifically infections and wound dehiscence, were obtained. Results: A total of 201 patients were recruited in our study: 64 in the Prevena group and 137 in the control group. There was a significant reduction in the number of open wounds in the Prevena group compared to the control group at the 2-week follow-up (10.9% Prevena vs 33.6% control; p = .0005). When evaluated in aggregate, there was a statistically significant reduction in the number of patients who succumbed to any complication in the Prevena arm compared with traditional dressings (13 (20.3%) Prevena vs 72 (52.6%) control; p < .0001). Conclusion: The results of our study suggest there should be a significant consideration for the use of NPWT as a prophylactic measure to reduce the risk of wound complications of primarily closed infra-inguinal incisions in vascular surgery patients following common vascular procedures. Its use is particularly effective for patients at enhanced risk of infection, especially those with poor vascularization from BMI, smoking, and diabetes. This leads to decreased trends in antibiotic use, ED visits, readmissions, and surgical revisions, which translates to decreased utilization of hospital resources and economic burden.
C1 [Kasten, Kody; Yang, Andrew; Shaffer, Lynn; Kociola, Samuel; Holland, Conor; Roche, Faith Anne; Pilbeam, Calvin] Mt Carmel Hlth Syst, Vasc Surg Gen Surg, 5300 N Meadows Dr, Grove City, OH 43123 USA.
RP Kasten, K (通讯作者)，Mt Carmel Hlth Syst, Vasc Surg Gen Surg, 5300 N Meadows Dr, Grove City, OH 43123 USA.
EM kody.kasten001@mchs.com
OI Kasten, Kody/0009-0003-9631-2681
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Bandyk DF, 2008, SEMIN VASC SURG, V21, P119, DOI 10.1053/j.semvascsurg.2008.05.008
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   Dormandy J, 1999, Semin Vasc Surg, V12, P154
   Martin ET, 2016, INFECT CONT HOSP EP, V37, P88, DOI 10.1017/ice.2015.249
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   Shiroky J, 2020, SURGERY, V167, P1001, DOI 10.1016/j.surg.2020.01.018
   Stannard JP, 2012, INT WOUND J, V9, P32, DOI 10.1111/j.1742-481X.2012.01017.x
   Suh H, 2016, ANN PLAS SURG, V76, P717, DOI 10.1097/SAP.0000000000000231
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   Zhao MY, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000022164
NR 15
TC 2
Z9 2
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD APR
PY 2025
VL 33
IS 2
BP 456
EP 461
DI 10.1177/17085381241247098
EA APR 2024
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 0NY6M
UT WOS:001202015700001
PM 38607337
DA 2026-07-24
ER
PT J
AU Yammine, K
   Abdallah, R
   Stiban, S
   Helou, M
   Hayek, F
   Assi, C
AF Yammine, Kaissar
   Abdallah, Ralph
   Stiban, Sonia
   Helou, Mariana
   Hayek, Fady
   Assi, Chahine
TI Monitoring negative pressure wound therapy for diabetic foot ulcers
   using WhatsApp
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Diabetic foot ulcer; Negative wound pressure therapy; WhatsApp; Wound
   healing
ID RELIABILITY; AMPUTATION; MORTALITY
AB Foot complications of patients with diabetes could lead to amputations and early death. Diabetic foot ulcers (DFU) are usually difficult to treat and impose huge financial burden. Monitoring wound progress is the mainstay of any treatment and alternatives to face-to-face consultations such as tele-medicine have been proposed. Very few papers explored the utility and effectiveness of monitoring DFU through instant messaging application such as WhatsApp. The aim of this study is to evaluate the validity of WhatsApp in monitoring diabetic wounds treated with negative pressure wound therapy (NPWT). Twenty-two patients were prospectively recruited. All patients had an initial face-to-face consultation and debridement. Dressings were changed twice per week at patient's residence and media files were sent by the wound nurse via Short Message Service (SMS). A subsequent face to face consultation was scheduled whenever a complication was suspected. The primary outcomes were the percentages of accurate cases a) where a new or recurrent infection was suspected, and a b) where a debridement was thought to be needed. Complete healing of the defect using NPWT was achieved in 10 patients and a skin graft procedure was needed in another 4 patients. Five patients needed further surgical debridement. Failure to heal was observed in 3 patients. Out of the seven cases where a new infection was suspected, five (71.5%) were confirmed on face-toface consultation. No confirmed cases of infection were observed during follow-up for those estimated as clean. Out of the 11 cases where debridement was favored based on WhatsApp media files, confirmation of a needed debridement was recorded in 8 (73%) cases. NPWT monitoring of for diabetic foot and leg ulcers using WhatsApp application was found to be an excellent method to document and track the wound process and complications. The excellent specificity and high sensibility should encourage for common use by healthcare. The results of this study could be also valuable for patients living in rural areas and in case of future pandemics.
C1 [Yammine, Kaissar; Assi, Chahine] Lebanese Amer Univ, Med Ctr, Rizk Hosp, Sch Med,Dept Orthoped Surg, Beirut, Lebanon.
   [Yammine, Kaissar; Stiban, Sonia] Lebanese Amer Univ, Rizk Hosp, Diabetic Foot Clin, Med Ctr, Beirut, Lebanon.
   [Abdallah, Ralph] Univ Toronto, Fac Arts & Sci, Toronto, ON, Canada.
   [Helou, Mariana] Lebanese Amer Univ, Med Ctr, Rizk Hosp, Sch Med,Dept Emergency Med, Beirut, Lebanon.
   [Hayek, Fady] Lebanese Amer Univ, Med Ctr, Rizk Hosp, Sch Med,Div Vasc Surg,Dept Gen Surg, Beirut, Lebanon.
C3 Lebanese American University; Lebanese American University; University
   of Toronto; Lebanese American University; Lebanese American University
RP Yammine, K (通讯作者)，Lebanese Amer Univ, Med Ctr, Rizk Hosp, Sch Med,Dept Orthoped Surg, Beirut, Lebanon.
EM cesaryam@gmail.com
RI helou, mariana/AAC-6267-2020; Assi, Chahine/AAD-7388-2020; Yammine,
   Kaissar/L-5994-2019
OI helou, mariana/0000-0001-8626-8988; Abdallah, Ralph/0009-0001-0529-8040;
   Yammine, Kaissar/0000-0003-0094-9892
CR Al Omar M, 2020, PHARM PRACT-GRANADA, V18, DOI [10.18549/PharmPract.2020.2.1841, 10.18549/pharmpract.2020.2.1841]
   Armstrong DG, 2017, NEW ENGL J MED, V376, P2367, DOI 10.1056/NEJMra1615439
   Ghanassia E, 2008, DIABETES CARE, V31, P1288, DOI 10.2337/dc07-2145
   Jeihooni Ali Khani, 2019, Indian J Endocrinol Metab, V23, P609, DOI [10.4103/ijem.ijem_439_19, 10.4103/ijem.IJEM_439_19]
   Kaka AS, 2023, J FOOT ANKLE RES, V16, DOI 10.1186/s13047-023-00610-6
   Kelahmetoglu O, 2020, INT WOUND J, V17, P1424, DOI 10.1111/iwj.13416
   Khoo SS, 2023, J HAND SURG-EUR VOL, V48, P419, DOI 10.1177/17531934231151202
   Paryavi E, 2016, J PEDIATR ORTHOPED, V36, P483, DOI 10.1097/BPO.0000000000000477
   Sartori AC, 2020, TELEMED E-HEALTH, V26, P1526, DOI 10.1089/tmj.2019.0305
   Singh N, 2005, JAMA-J AM MED ASSOC, V293, P217, DOI 10.1001/jama.293.2.217
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   Stahl I, 2017, SPINE J, V17, P161, DOI 10.1016/j.spinee.2016.08.021
   Téot L, 2020, INT J LOW EXTR WOUND, V19, P197, DOI 10.1177/1534734619894485
   Thorud JC, 2016, J FOOT ANKLE SURG, V55, P591, DOI 10.1053/j.jfas.2016.01.012
   van Dieren S, 2010, EUR J CARDIOV PREV R, V17, pS3, DOI 10.1097/01.hjr.0000368191.86614.5a
   Yammine Kaissar, 2022, Foot (Edinb), V50, P101872, DOI [10.1016/j.foot.2021.101872, 10.1016/j.foot.2021.101872]
   Yammine K, 2020, J VASC SURG, V72, P2197, DOI 10.1016/j.jvs.2020.07.086
NR 17
TC 3
Z9 4
U1 1
U2 11
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2024
VL 33
IS 1
BP 1
EP 4
DI 10.1016/j.jtv.2024.01.001
EA MAR 2024
PG 4
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA OB7G1
UT WOS:001204859200001
PM 38220561
DA 2026-07-24
ER
PT J
AU Nabata, KJ
   Rai, S
   Zhao, DR
   Macneill, AJ
   Hamilton, TD
AF Nabata, Kylie J.
   Rai, Sabrina
   Zhao, Darren
   Macneill, Andrea J.
   Hamilton, Trevor D.
TI Negative Pressure Wound Therapy to Reduce Surgical Site Infections after
   CRS/HIPEC
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Article
ID LAPAROTOMY; SURGERY; TRIAL
AB Background. Surgical site infections (SSIs) are a common cause of morbidity after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancy. Negative pressure wound therapy (NPWT) has been proposed as a method to reduce the rates of SSIs; however, there is paucity in the literature on the efficacy in this population. The goal of this study was to determine whether routine use of NPWT in patients undergoing CRS/HIPEC could reduce the risk of developing SSI. Methods. We performed a retrospective before-after study to assess the rates of SSI with NPWT compared with a standard postoperative surgical dressing (SSD) in all patients undergoing CRS/HIPEC from November 2013 to December 2021 at a single tertiary care center. The primary outcome was rate of SSI. A multivariate logistic regression analysis was performed to evaluate for risk factors for SSI. Results. A total of 178 patients were treated with CRS/HIPEC over the study period. Seventy patients had placement of SSD, and 108 patients had placement of NPWT. Rates of SSI were 11.4% (8/70) and 5.6% (6/108) in the two groups, respectively (p = 0.16). On multivariate analysis, patients treated with NPWT had a significantly lower risk of developing an SSI (OR 0.24 [0.06, 0.92], p = 0.037). Patients living >50 km from the hospital had significantly higher risk of developing SSI (OR 2.03 [1.09, 3.78], p = 0.026). Conclusions. These results suggest that routine use of NPWT can reduce the risk of developing an SSI in patients undergoing CRS/HIPEC for peritoneal malignancy.
C1 [Nabata, Kylie J.; Rai, Sabrina; Zhao, Darren; Macneill, Andrea J.; Hamilton, Trevor D.] Univ British Columbia, Gordon & Leslie Diamond Hlth Care Ctr, Dept Surg, Vancouver, BC, Canada.
C3 University of British Columbia
RP Hamilton, TD (通讯作者)，Univ British Columbia, Gordon & Leslie Diamond Hlth Care Ctr, Dept Surg, Vancouver, BC, Canada.
EM trevor.hamilton@vch.ca
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NR 37
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1068-9265
EI 1534-4681
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD JUL
PY 2024
VL 31
IS 7
BP 4735
EP 4740
DI 10.1245/s10434-024-15283-z
EA APR 2024
PG 6
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA TU9J9
UT WOS:001207153500004
PM 38653941
DA 2026-07-24
ER
PT J
AU Li, ST
   Nong, QW
   Wu, YJ
   Liu, D
AF Li, Shuntang
   Nong, Qingwen
   Wu, Yajun
   Liu, Daen
TI Healing an ischial tuberosity pressure ulcer in a patient with
   neurogenic heterotopic ossification: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hip; negative pressure wound therapy; neurogenic heterotopic
   ossification; pressure ulcer; spinal cord injury; wound; wound care;
   wound healing
ID SPINAL-CORD-INJURY; MYOCUTANEOUS FLAP; RECONSTRUCTION; MANAGEMENT
AB Neurogenic heterotopic ossification (NHO) is widely recognised as an aberrant bone formation in soft tissue following central nervous system injury. It is most frequently associated with pain and limited movement, especially in the hip. However, it may be neglected in patients with paraplegia with a pressure ulcer (PU). We report the case of an 18-year-old male patient who presented with a hard-to-heal ischial tuberosity PU and who had undergone three operations at other hospitals during the previous six months, which had failed to repair the PU. There was a history of paraplegia as a consequence of spinal cord injury two years previously. Computed tomography and three-dimensional reconstruction showed massive heterotopic ossification (HO) in the wound bed and around the right hip. Histological findings were consistent with a diagnosis of HO. The HO around the wound was completely excised, negative pressure wound therapy was used to promote granulation, and a gluteus maximus musculocutaneous flap was used to cover the wound. We conclude that for patients with paraplegia, with a hard-to-heal PU, it should be determined whether it is associated with NHO. Surgical resection of HO surrounding the wound and improving the microcirculation are critical for repair and reconstruction of these PUs.
C1 [Li, Shuntang; Nong, Qingwen; Wu, Yajun; Liu, Daen] Guangxi Med Univ, Dept Burns & Plast Surg, Affiliate Hosp 1, Nanning 530021, Guangxi, Peoples R China.
C3 Guangxi Medical University
RP Li, ST (通讯作者)，Guangxi Med Univ, Dept Burns & Plast Surg, Affiliate Hosp 1, Nanning 530021, Guangxi, Peoples R China.
EM 0504410155@163.com
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NR 27
TC 0
Z9 0
U1 5
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2024
VL 33
SU 3A
BP LXIX
EP LXXIII
DI 10.12968/jowc.2024.33.Sup3a.lxix
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ON8J2
UT WOS:001208042300003
PM 38457272
DA 2026-07-24
ER
PT J
AU Ainslie-Garcia, M
   Anderson, LA
   Bloch, BV
   Board, TN
   Chen, AF
   Craigie, S
   Danker, W
   Gunja, N
   Harty, J
   Hernandez, VH
   Lebedeva, K
   Mont, MA
   Nunley, RM
   Parvizi, J
   Perka, C
   Piuzzi, NS
   Rolfson, O
   Rychlik, J
   Romanini, E
   Sanz-Ruiz, P
   Sierra, RJ
   Suleiman, L
   Tsiridis, E
   Vendittoli, PA
   Wangen, H
   Zagra, L
AF Ainslie-Garcia, Margaret
   Anderson, Lucas A.
   V. Bloch, Benjamin
   Board, Tim N.
   Chen, Antonia F.
   Craigie, Samantha
   Danker, Walter
   Gunja, Najmuddin
   Harty, James
   Hernandez, Victor H.
   Lebedeva, Kate
   Mont, Michael A.
   Nunley, Ryan M.
   Parvizi, Javad
   Perka, Carsten
   Piuzzi, Nicolas S.
   Rolfson, Ola
   Rychlik, Joshua
   Romanini, Emilio
   Sanz-Ruiz, Pablo
   Sierra, Rafael J.
   Suleiman, Linda
   Tsiridis, Eleftherios
   Vendittoli, Pascal-Andre
   Wangen, Helge
   Zagra, Luigi
TI International Delphi Study on Wound Closure and Dressing Management in
   Joint Arthroplasty: Part 1: Total Knee Arthroplasty
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE total knee arthroplasty; wound closure techniques; dressing management;
   Delphi study; surgical best practices; venous thromboembolism
   prophylaxis
ID RISK CALCULATOR; TOTAL HIP; INFECTION; READMISSION; CONSENSUS; BURDEN
AB Background: The purpose of this modified Delphi study was to obtain consensus on wound closure and dressing management in total knee arthroplasty (TKA). Methods: The Delphi panel included 20 orthopaedic surgeons from Europe and North America. There were 26 statements identified using a targeted literature review. Consensus was developed for the statements with up to three rounds of anonymous voting per topic. Panelists ranked their agreement with each statement on a five-point Likert scale. An a priori threshold of >= 75% was required for consensus. Results: All 26 statements achieved consensus after three rounds of anonymous voting. Wound closure- related interventions that were recommended for use in TKA included: 1) closing in semi -flexion versus extension (superior range of motion); 2) using aspirin for venous thromboembolism prophylaxis over other agents (reduces wound complications); 3) barbed sutures over non-barbed sutures (lower wound complications, better cosmetic appearances, shorter closing times, and overall cost savings); 4) mesh- adhesives over other skin closure methods (lower wound complications, higher patient satisfaction scores, lower rates of readmission); 5) silver-impregnated dressings over standard dressings (lower wound complications, decreased infections, fewer dressing changes); 6) in high -risk patients, negative pressure wound therapy over other dressings (lower wound complications, decreased reoperations, fewer dressing changes); and 7) using triclosan-coated over non-antimicrobial-coated sutures (lower risks of surgical site infection). Conclusions: Using a modified Delphi approach, the panel achieved consensus on 26 statements per- taining to wound closure and dressing management in TKA. This study forms the basis for identifying critical evidence supported by clinical practice for wound management to help reduce variability, advance standardization, and ultimately improve outcomes during TKA. The results presented here can serve as the foundation for knowledge, education, and improved clinical outcomes for surgeons per- forming TKAs. (c) 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Ainslie-Garcia, Margaret; Craigie, Samantha; Lebedeva, Kate; Rychlik, Joshua] EVERSANA, Dept Value & Evidence, Burlington, ON, Canada.
   [Anderson, Lucas A.] Univ Utah, Orthopaed Ctr, Dept Orthopaed, Salt Lake City, UT USA.
   [V. Bloch, Benjamin] City Hosp, Nottingham Elect Orthopaed Serv, Nottingham, England.
   [Board, Tim N.] Wrightington Hosp, Ctr Hip Surg, Orthopaed, Wigan, England.
   [Chen, Antonia F.] Harvard Med Sch, Brigham & Womens Hosp, Dept Orthopaed Surg, Boston, MA USA.
   [Danker, Walter; Gunja, Najmuddin] J&J MedTech, Hlth Econ & Market Access, Raritan, NJ USA.
   [Harty, James] Cork Univ Hosp, Trauma & Orthopaed Dept, Cork, Ireland.
   [Hernandez, Victor H.] Univ Miami, Jackson Mem Hosp, Dept Orthopaed Surg & Rehabil, Miami, FL USA.
   [Mont, Michael A.] Sinai Hosp Baltimore, LifeBridge Hlth, Rubin Inst Adv Orthoped, Baltimore, MD USA.
   [Nunley, Ryan M.] Washington Univ, Dept Orthopaed Surg, St Louis, MO USA.
   [Parvizi, Javad] Thomas Jefferson Univ, Rothman Inst, Dept Orthopaed, Philadelphia, PA USA.
   [Perka, Carsten] Ctr Muskuloskeletale Chirurg, Orthopad Univ Klin Charite, Berlin, Germany.
   [Piuzzi, Nicolas S.] Cleveland Clin Fdn, Dept Orthoped Surg, Cleveland, OH USA.
   [Rolfson, Ola] Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Orthopead, Gothenburg, Sweden.
   [Romanini, Emilio] Polo Sanit San Feliciano, Ctr Hip & Knee Arthroplasty, Rome, Italy.
   [Sanz-Ruiz, Pablo] Univ Complutense Madrid, Fac Med, Dept Surg, Madrid, Spain.
   [Sierra, Rafael J.] Mayo Clin, Dept Orthoped Surg, Rochester, MN USA.
   [Suleiman, Linda] Northwestern Univ, Feinberg Sch Med, Dept Orthopaed Surg, Chicago, IL USA.
   [Tsiridis, Eleftherios] Aristotle Univ Thessaloniki, Gen Hosp Papageorgiou, Med Sch, Acad Orthoped Unit, Thessaloniki, Greece.
   [Vendittoli, Pascal-Andre] Univ Montreal, Maisonneuve Rosemont Hosp, Dept Surg, Montreal, PQ, Canada.
   [Wangen, Helge] Innlandet Hosp Trust, Dept Orthopaed Surg, Elverum, Norway.
   [Zagra, Luigi] IRCCS Ist Ortoped Galeazzi, Hip Dept, Milan, Italy.
C3 Utah System of Higher Education; University of Utah; University of
   Nottingham; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; University
   College Cork; University of Miami; Sinai Hospital of Baltimore;
   Washington University (WUSTL); Thomas Jefferson University; Rothman
   Institute; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; Cleveland Clinic Foundation;
   University of Gothenburg; Complutense University of Madrid; Mayo Clinic;
   Northwestern University; Feinberg School of Medicine; Papageorgiou
   Hospital; Aristotle University of Thessaloniki; Universite de Montreal;
   Innlandet Hospital Trust; IRCCS Istituto Ortopedico Galeazzi
RP Mont, MA (通讯作者)，Sinai Hosp Baltimore, Rubin Inst Adv Orthoped, 2401 West Belvedere Ave, Baltimore, MD 21215 USA.
RI ; Danker III, Walter/AAP-5078-2020; Perka, Carsten/ABG-6505-2021;
   sanz-ruiz, pablo/H-6539-2015; Rolfson, Ola/AAT-2206-2020; Vendittoli,
   Pascal-Andre/J-9621-2013; Bloch, Benjamin/I-1041-2019; /I-9296-2019;
   Zagra, Luigi/PFZ-1383-2026; Hernandez, Victor H/AAG-4458-2020
OI Piuzzi, Nicolas S/0000-0003-3007-7538; Danker III,
   Walter/0000-0002-9741-5821; Perka, Carsten/0000-0002-0993-581X;
   sanz-ruiz, pablo/0000-0002-7588-1880; Bloch,
   Benjamin/0000-0002-2305-7478; Hernandez, Victor H/0000-0003-1745-3324
FU Cincinnati, Ohio
FX We wish to thank Ethicon, Cincinnati, Ohio for the support of this
   project. Special thanks to Stephanie Leon. We would also like to thank
   CRG-EVERSANA, Burlington, Ontario, Canada, for their assistance.
CR Antonelli B, 2019, ARTHROPLASTY, V1, DOI 10.1186/s42836-019-0003-7
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   Yoon BH, 2020, J ARTHROPLASTY, V35, P933, DOI 10.1016/j.arth.2019.11.029
   Zmistowski B, 2013, J BONE JOINT SURG AM, V95A, P1869, DOI 10.2106/JBJS.L.00679
NR 28
TC 13
Z9 17
U1 1
U2 4
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD APR
PY 2024
VL 39
IS 4
BP 878
EP 883
DI 10.1016/j.arth.2023.12.032
EA MAR 2024
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA OS2Q3
UT WOS:001209203400001
PM 38244638
OA hybrid
DA 2026-07-24
ER
PT J
AU Taeger, CD
   Muehle, C
   Kruppa, P
   Prantl, L
   Biermann, N
AF Taeger, Christian D.
   Muehle, Clemens
   Kruppa, Philipp
   Prantl, Lukas
   Biermann, Niklas
TI Negative Pressure Wound Therapy-A Vacuum-Mediated Positive Pressure
   Wound Therapy and a Closer Look at the Role of the Laser Doppler
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE negative pressure wound therapy; positive pressure; laser doppler;
   perfusion; compression; NPWT
ID MICROVASCULAR BLOOD-FLOW; ASSISTED CLOSURE; PERFUSION; INCISION;
   MANAGEMENT; MECHANISMS; SURGERY
AB Background: Negative pressure wound therapy (NPWT) is an intensely investigated topic, but its mechanism of action accounts for one of the least understood ones in the area of wound healing. Apart from a misleading nomenclature, by far the most used diagnostic tool to investigate NPWT, the laser Doppler, also has its weaknesses regarding the detection of changes in blood flow and velocity. The aim of the present study is to explain laser Doppler readings within the context of NPWT influence. Methods: The cutaneous microcirculation beneath an NPWT system of 10 healthy volunteers was assessed using two different laser Dopplers (O2C/Rad-97 (R)). This was combined with an in vitro experiment simulating the compressing and displacing forces of NPWT on the arterial and venous system. Results: Using the O2C, a baseline value of 194 and 70 arbitrary units was measured for the flow and relative hemoglobin, respectively. There was an increase in flow to 230 arbitrary units (p = 0.09) when the NPWT device was switched on. No change was seen in the relative hemoglobin (p = 0.77). With the Rad-97 (R), a baseline of 92.91% and 0.17% was measured for the saturation and perfusion index, respectively. No significant change in saturation was noted during the NPWT treatment phase, but the perfusion index increased to 0.32% (p = 0.04). Applying NPWT compared to the arteriovenous-vessel model resulted in a 28 mm and 10 mm increase in the venous and arterial water column, respectively. Conclusions: We suspect the vacuum-mediated positive pressure of the NPWT results in a differential displacement of the venous and arterial blood column, with stronger displacement of the venous side. This ratio may explain the increased perfusion index of the laser Doppler. Our in vitro setup supports this finding as compressive forces on the bottom of two water columns within a manometer with different resistances results in unequal displacement.
C1 [Taeger, Christian D.; Muehle, Clemens; Prantl, Lukas; Biermann, Niklas] Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, D-93053 Regensburg, Germany.
   [Kruppa, Philipp] Ernst Bergmann Klinikum, Dept Plast Hand & Reconstruct Surg, D-14467 Potsdam, Germany.
C3 University of Regensburg; Klinikum Ernst von Bergmann
RP Taeger, CD (通讯作者)，Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, D-93053 Regensburg, Germany.
EM taeger.christian@gmail.com; clemens-muehle@web.de; kruppaph@gmail.com;
   lukas.prantl@klinik.uni-regensburg.de;
   niklas.biermann@klinik.uni-regensburg.de
RI prantl, Lukas/AAM-1848-2021; Kruppa, Philipp/AAQ-1783-2020
OI prantl, Lukas/0000-0003-2454-2499; Kruppa, Philipp/0000-0003-1654-7257
FU Manfred Roth Stiftung
FX No Statement Available
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 29
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR
PY 2024
VL 13
IS 8
AR 2351
DI 10.3390/jcm13082351
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OX5H8
UT WOS:001210585000001
PM 38673623
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yin, RY
   Gursky, A
   Falade, I
   Knox, J
   Gomez-Sanchez, C
   Soroudi, D
   Piper, M
   Hoffman, W
   Hansen, SL
AF Yin, Raymond
   Gursky, Alexis
   Falade, Israel
   Knox, Jacquelyn
   Gomez-Sanchez, Clara
   Soroudi, Daniel
   Piper, Merisa
   Hoffman, William
   Hansen, Scott L.
TI The Utility of Prevena Negative Pressure Wound Therapy on Groin
   Incisions for Critical Limb-Threatening Ischemia A Single Institution
   Experience
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE Prevena; iNPWT; critical limb-threatening ischemia; plastic surgery
ID PROPHYLACTIC MUSCLE FLAPS; INFECTION; RECONSTRUCTION; COMPLICATIONS;
   MANAGEMENT
AB Background: Incisional negative pressure wound therapy (iNPWT) is an adjunctive treatment that uses constant negative pressure suction to facilitate healing. The utility of this treatment modality on vascular operations for critical limb-threatening ischemia (CLTI) has yet to be elucidated. This study compares the incidence of postoperative wound complications between the Prevena Incision Management System, a type of iNPWT, and standard wound dressings for vascular patients who also underwent plastic surgery closure of groin incisions for CLTI. Method: We performed a retrospective cohort study of 40 patients with CLTI who underwent 53 open vascular surgeries with subsequent sartorius muscle flap closure. Patient demographics, intraoperative details, and wound complications were measured from 2015 to 2018 at the University of California San Francisco. Two cohorts were generated based on the modality of postoperative wound management and compared on wound healing outcomes. Results: Of the 53 groin incisions, 29 were managed with standard dressings, and 24 received iNPWT. Patient demographics, comorbidities, and operative characteristics were similar between the 2 groups. Patients who received iNPWT had a significantly lower rate of infection (8.33% vs 31.0%, P = 0.04) and dehiscence (0% vs 41.3%, P < 0.01). Furthermore, the iNPWT group had a significantly lower rate of reoperation (0% vs 17.2%, P = 0.03) for wound complications within 30 days compared with the control group and a moderately reduced rate of readmission (4.17% vs 20.7%, P = 0.08). Conclusions: Rates of infection, reoperation, and dehiscence were significantly reduced in patients whose groin incisions were managed with iNPWT compared with standard wound care. Readmission rates were also decreased, but this difference was not statistically significant. Our results suggest that implementing iNPWT for the management of groin incisions, particularly in patients undergoing vascular operations for CLTI, may significantly improve clinical outcomes.
C1 [Yin, Raymond; Falade, Israel; Soroudi, Daniel] Univ Calif San Francisco, Sch Med, San Francisco, CA USA.
   [Gursky, Alexis] SUNY Upstate Med Univ, Norton Coll Med, Syracuse, NY USA.
   [Knox, Jacquelyn; Piper, Merisa; Hoffman, William; Hansen, Scott L.] Univ Calif San Francisco, Div Plast & Reconstruct Surg, San Francisco, CA USA.
   [Gomez-Sanchez, Clara] Univ Calif San Francisco, Dept Surg, Div Vasc & Endovasc Surg, San Francisco, CA USA.
   [Piper, Merisa] Univ Calif San Francisco, Div Plast & Reconstruct Surg, Dept Surg, 350 Parnassus Ave,M593, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   State University of New York (SUNY) System; SUNY Upstate Medical
   University; University of California System; University of California
   San Francisco; University of California System; University of California
   San Francisco; University of California System; University of California
   San Francisco
RP Piper, M (通讯作者)，Univ Calif San Francisco, Div Plast & Reconstruct Surg, Dept Surg, 350 Parnassus Ave,M593, San Francisco, CA 94143 USA.
EM raymond.yin@ucsf.edu; alexis.gursky@gmail.com; israel.falade@ucsf.edu;
   jacquelyn.knox@ucsf.edu; clara.gomez-sanchez@ucsf.edu;
   daniel.soroudi@ucsf.edu; Merisa.Piper@ucsf.edu;
   william.hoffman@ucsf.edu; scott.hansen@ucsf.edu
RI ; Falade, Israel/JUU-8119-2023
OI Soroudi, Daniel/0009-0001-4022-7555; Piper, Merisa/0000-0002-9458-3782;
   Gursky, Alexis/0000-0002-2479-9828; 
CR Calligaro K D, 1994, Ann Vasc Surg, V8, P31, DOI 10.1007/BF02133403
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NR 27
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2024
VL 92
IS 5S
SU 3
BP S331
EP S335
DI 10.1097/SAP.0000000000003802
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OZ3R0
UT WOS:001211064500002
PM 38689414
DA 2026-07-24
ER
PT J
AU Ye, HY
   Xu, XX
   Sun, Y
   Zhao, XH
AF Ye, Hongyu
   Xu, Xinxin
   Sun, Yi
   Zhao, Xiaohang
TI Efficacy of combining a medial superior malleolar perforator flap from
   the posterior tibial artery with a vacuum-assisted closure dressing for
   skin and soft tissue defects of the Achilles tendon area
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Posterior tibial artery; Achilles tendon; perforating branch; skin flap
ID LOWER-EXTREMITY; PROPELLER FLAP; RECONSTRUCTION; REPAIR; FOOT
AB Objective: This randomized clinical trial aimed to investigate the clinical efficacy of combining a medial superior malleolar perforator flap from the posterior tibial artery (PTAPF) with a vacuum -assisted closure (VAC) dressing for skin and soft tissue defects in the Achilles tendon area. Methods: Twenty-eight patients were randomly divided into two equally sized groups: the control group received treatment with a medial superior malleolar perforator flap, while the experimental group was treated with a perforator flap from the posterior tibial artery in combination with a VAC dressing. Perioperative data, including average operative time, intraoperative blood loss, intraoperative complications, time to ambulation, and hospital stay after surgery, were recorded. Clinical outcomes were assessed based on the time to first weight -bearing walking, time to full weight -bearing activity, Visual Analog Scale (VAS) score, American Orthopaedic Foot and Ankle Society hindfoot and ankle score, and the range of motion for ankle plantar flexion. Results: The patients were monitored for 3-12 months (average, 8.5), and it was observed that the flaps remained stable without enlargement, and their texture and color were similar to the surrounding tissue. Significantly enhanced postoperative indices were noted in the experimental group compared to the control group (P<0.05). Conclusion: The medial superior malleolar perforator flap from the posterior tibial artery, especially when combined with a VAC dressing, proves to be an effective method for repairing medium-sized skin defects in the Achilles tendon area. This approach offers several benefits, including a reliable blood supply, simplicity of the procedure, decreased damage to the donor site, improved aesthetic outcomes, and fewer postoperative complications.
C1 [Ye, Hongyu; Sun, Yi; Zhao, Xiaohang] Yongkang Orthoped Hosp, Dept Microsurg, 9 Wenhuagong Rd,Xicheng St, Yongkang 321300, Zhejiang, Peoples R China.
   [Xu, Xinxin] Dongyang Tradit Chinese Med Hosp, Dept Internal Med, Dongyang 321300, Zhejiang, Peoples R China.
RP Zhao, XH (通讯作者)，Yongkang Orthoped Hosp, Dept Microsurg, 9 Wenhuagong Rd,Xicheng St, Yongkang 321300, Zhejiang, Peoples R China.
EM Xiaohangzhao@yeah.net
RI Sun, Yi/A-5544-2016
FU Natural Scien- ce Foundation of Anhui Province [2108085- MH289]
FX <BOLD>Acknowledgements</BOLD> This work was supported by the Natural
   Scien- ce Foundation of Anhui Province (2108085- MH289) .
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NR 32
TC 2
Z9 3
U1 0
U2 6
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2024
VL 16
IS 4
BP 1209
EP 1218
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA PO3B0
UT WOS:001214968800018
PM 38715817
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Larson, BJ
   Roakes, A
   Yurick, S
   Netravali, NA
AF Larson, Barrett J.
   Roakes, Ashley
   Yurick, Steve
   Netravali, Nathan A.
TI Precision in Prevention: Tailoring Single-Use Negative Pressure Wound
   Therapy Utilization Through Artificial Intelligence-Based Surgical Site
   Complications Risk and Cost Modeling
SO SURGICAL INFECTIONS
LA English
DT Article
DE closed surgical incisions; single-use negative pressure wound therapy;
   NPWT; surgical site complications; machine learning; risk prediction
ID CLINICAL REGISTRY; CLAIMS DATA; INFECTIONS; DRESSINGS; CONSEQUENCES;
   IMPACT
AB Background: Surgical site complications (SSCs) are common, yet preventable hospital-acquired conditions. Single-use negative pressure wound therapy (sNPWT) has been shown to be effective in reducing rates of these complications. In the era of value-based care, strategic allocation of sNPWT is needed to optimize both clinical and financial outcomes.Materials and Methods: We conducted a retrospective analysis using data from the Premier Healthcare Database (2017-2021) for 10 representative open procedures in orthopedic, abdominal, cardiovascular, cesarean delivery, and breast surgery. After separating data into training and validation sets, various machine learning algorithms were used to develop pre-operative SSC risk prediction models. Model performance was assessed using standard metrics and predictors of SSCs were identified through feature importance evaluation. Highest-performing models were used to simulate the cost-effectiveness of sNPWT at both the patient and population level.Results: The prediction models demonstrated good performance, with an average area under the curve of 76%. Prominent predictors across subspecialities included age, obesity, and the level of procedure urgency. Prediction models enabled a simulation analysis to assess the population-level cost-effectiveness of sNPWT, incorporating patient and surgery-specific factors, along with the established efficacy of sNPWT for each surgical procedure. The simulation models uncovered significant variability in sNPWT's cost-effectiveness across different procedural categories.Conclusions: This study demonstrates that machine learning models can effectively predict a patient's risk of SSC and guide strategic utilization of sNPWT. This data-driven approach allows for optimization of clinical and financial outcomes by strategically allocating sNPWT based on personalized risk assessments.
C1 [Larson, Barrett J.; Roakes, Ashley; Yurick, Steve; Netravali, Nathan A.] Smith Nephew Inc, 2875 Railrd St, Pittsburgh, PA 15222 USA.
   [Larson, Barrett J.] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA USA.
C3 Stanford University
RP Larson, BJ (通讯作者)，Smith Nephew Inc, 2875 Railrd St, Pittsburgh, PA 15222 USA.
EM barrett.larson@stanford.edu
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   Strugala V, 2017, SURG INFECT, V18, P810, DOI 10.1089/sur.2017.156
   Sullivan E, 2017, SURG INFECT, V18, P451, DOI 10.1089/sur.2017.072
   Tunthanathip T, 2019, NEUROSURG FOCUS, V47, DOI 10.3171/2019.5.FOCUS19241
   Wang HS, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.771608
   Witt-Majchrzak Anna, 2015, Pol Przegl Chir, V86, P456, DOI [10.2478/pjs-2014-0082, 10.2478/pjs-2014-0082]
   World Union of Wound Healing Societies, 2016, CLOS SURG INC MAN UN
   Wu GS, 2022, ANN MED SURG, V84, DOI 10.1016/j.amsu.2022.104956
   Zhu Y, 2021, J AM COLL SURGEONS, V232, P963, DOI 10.1016/j.jamcollsurg.2021.03.026
NR 31
TC 0
Z9 1
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD MAY 1
PY 2024
VL 25
IS 4
BP 315
EP 321
DI 10.1089/sur.2023.274
EA MAY 2024
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA QT2H4
UT WOS:001216723200001
PM 38696615
OA hybrid
DA 2026-07-24
ER
PT J
AU Moris, V
   Cristofari, S
   See, LA
   Guillier, D
   Zwetyenga, N
   Pluvy, I
AF Moris, Vivien
   Cristofari, Sarra
   See, Leslie Ann
   Guillier, David
   Zwetyenga, Narcisse
   Pluvy, Isabelle
TI Randomized comparative study of negative pressure wound therapy versus
   compression dressing on split-thickness skin grafts of the lower limbs
   in an elderly population
SO EXPERT REVIEW OF MEDICAL DEVICES
LA English
DT Article
DE Skin graft; lower limbs; elderly population; NPWT therapy; compression
   dressing; graft necrosis
ID VACUUM-ASSISTED CLOSURE; CONVENTIONAL THERAPY; MANAGEMENT; OUTCOMES;
   TRIAL
AB IntroductionFailure to adequately secure the skin graft to the lower limbs recipient bed can result in loss of the graft. Our objective was to compare the healing of split-thickness skin grafts three weeks postoperatively, using either negative pressure wound therapy (NPWT) or conventional compression bandaging.MethodsIn this multicenter randomized controlled study, patients with tissue loss ranging from 50 cm2 to 600 cm2 on the lower limbs and treated with split-thickness skin grafts were included in three French hospitals. A digital photographic evaluation was performed at 3 weeks.ResultsDuring 9 years, 70 patients were included in the study and allocated to a treatment group. The grafted area was similar in both groups. Loss of graft was significantly reduced in the NPWT group with 14.6 cm2 compared to 29 cm2 in the control group (p = 0.0003). The hospital stay was also significantly reduced in the NPWT group, at 4 days versus 6.5 days in the control group (p = 0.0284). In the NPWT group, 60% reported pain compared to 22.9% in the control group (p = 0.0048).ConclusionsThe use of NPWT dressings improves skin graft take by reducing necrosis, improving the graft's adherence to the recipient site, and reducing hospital length-of-stay.
C1 [Moris, Vivien; See, Leslie Ann; Guillier, David] CHU Dijon, Serv Chirurg Maxillo Faciale Plast Reconstructrice, Chirurg Main, 14 Rue Paul Gaffarel, F-21000 Dijon, France.
   [Zwetyenga, Narcisse] Hop Tenon, Serv Chirurg Plast Reconstruct Esthet Microchirurg, Paris, France.
   [Cristofari, Sarra] Univ Bourgogne Franche Comte, Lipids Nutr Canc Team NuTox, UMR866, Dijon, France.
   [Pluvy, Isabelle] CHU Jean Minjoz, Serv Chirurg Orthoped Traumatol Plast Reconstructr, Besancon, France.
C3 Universite Bourgogne Europe; CHU Dijon Bourgogne; Assistance Publique
   Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Tenon
   - APHP; Universite Bourgogne Europe; Institut Agro; Institut Agro Dijon;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Marie et Louis Pasteur; CHU Besancon
RP Moris, V (通讯作者)，CHU Dijon, Serv Chirurg Maxillo Faciale Plast Reconstructrice, Chirurg Main, 14 Rue Paul Gaffarel, F-21000 Dijon, France.
EM morisvivien@gmail.com
RI moris, vivien/MPJ-6556-2025
OI moris, vivien/0000-0001-5594-2394
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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   Brower R. G., 2009, Critical Care Medicine, V37, ps422, DOI 10.1097/CCM.0b013e3181b6e30a
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NR 31
TC 3
Z9 3
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1743-4440
EI 1745-2422
J9 EXPERT REV MED DEVIC
JI Expert Rev. Med. Devices
PD JUN 2
PY 2024
VL 21
IS 6
BP 519
EP 526
DI 10.1080/17434440.2024.2350494
EA MAY 2024
PG 8
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA UU6N6
UT WOS:001217316300001
PM 38712592
DA 2026-07-24
ER
PT J
AU Rezk, F
   Åstrand, H
   Svensson-Björk, R
   Hasselmann, J
   Nyman, J
   Butt, T
   Bilos, L
   Pirouzram, A
   Acosta, S
AF Rezk, Francis
   Astrand, Hakan
   Svensson-Bjork, Robert
   Hasselmann, Julien
   Nyman, Johan
   Butt, Talha
   Bilos, Linda
   Pirouzram, Artai
   Acosta, Stefan
TI Multicenter parallel randomized trial evaluating incisional negative
   pressure wound therapy for the prevention of surgical site infection
   after lower extremity bypass
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
DE Incisional negative pressure wound therapy; Lower extremity bypass;
   Surgical site infection; Wound dehiscence
ID ARTERIAL RECONSTRUCTION; ANTIBIOTIC-PROPHYLAXIS; COMPLICATIONS;
   ISCHEMIA; TRIMETHOPRIM/SULFAMETHOXAZOLE; REVASCULARIZATION;
   METAANALYSIS; MANAGEMENT
AB Objective: Incisional negative pressure wound therapy (iNPWT) applied over all incisions after lower extremity bypass in the prevention of surgical site infections (SSIs) is unclear. The primary and secondary aims of this study were to investigate if prophylactic iNPWT after the elective lower extremity bypass prevents SSI and other surgical wound complications. Methods: This was a multicenter, parallel, randomized controlled trial. Patients undergoing elective lower extremity bypass in 3 hospitals were randomized to either iNPWT or standard dressings. SSIs or other wound complications were assessed within the fi rst 90 days by wound care professionals blinded to the randomized result. The validated Additional treatment, Serous discharge, Erythema, Purulent exudate, Separation of deep tissues, Isolation of bacteria, and Stay (ASEPSIS) score was used to objectively assess the wounds. ASEPSIS score $ 21 is de fi ned as an SSI. Unilateral and bilateral groups were analyzed with the Fisher exact test and the McNemar test, respectively. Results: In the unilateral group (n = 100), the incidence of SSI in the iNPWT group was 34.9% (15/43), compared with 40.3% (23/57) in the control group, according to the ASEPSIS score ( P = .678). In the bilateral group (n = 7), the SSI rate was 14.3% (1/7) in the iNPWT group compared with 14.3% (1/7) in the control group ( P = 1.00). In the unilateral group, there was a higher wound dehiscence rate in the control group (43.9%) compared with the iNPWT group (23.3%) ( P = .0366). No serious iNPWT-related adverse events were recorded. Conclusions: There was no reduction of SSI rates in leg incisions with iNPWT compared with standard dressings in patients undergoing elective lower extremity bypass, whereas iNPWT reduced the incidence of wound dehiscence.
C1 [Rezk, Francis; Svensson-Bjork, Robert; Hasselmann, Julien; Nyman, Johan; Butt, Talha; Acosta, Stefan] Lund Univ, Dept Clin Sci, SE-20502 Malmo, Sweden.
   [Rezk, Francis; Astrand, Hakan] Reg Jonkoping Cty, Dept Surg, Jonkoping, Sweden.
   [Nyman, Johan; Butt, Talha] Skane Univ Hosp, Dept Cardiothorac & Vasc Surg, Malmo, Sweden.
   [Bilos, Linda; Pirouzram, Artai] Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.
   [Bilos, Linda; Pirouzram, Artai] Linkoping Univ Hosp, Dept Cardiothorac & Vasc Surg, Linkoping, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Linkoping
   University; Linkoping University
RP Rezk, F (通讯作者)，Lund Univ, Dept Clin Sci, SE-20502 Malmo, Sweden.
EM francis.rezk@med.lu.se
RI ; Acosta, Stefan/JAX-3225-2023
OI Rezk, Francis/0000-0002-1236-6363; Acosta, Stefan/0000-0002-3225-0798;
   Butt, Talha/0000-0001-8443-2035
FU Lund University; Swedish Medical Research Council [2019-00435]; Hulda
   Almroth Foundation; Swedish government under the ALF agreement; Region
   Skane; Skane University Hospital; Swedish Research Council [2019-00435]
   Funding Source: Swedish Research Council
FX Open-access funding is provided by Lund University. Research funds were
   received from the Swedish Medical Research Council (2019-00435) , the
   Hulda Almroth Foundation, Skane University Hospital, Region Skane, and
   the Swedish government under the ALF agreement.
CR Acosta S, 2013, ClinicalTrials.gov
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NR 43
TC 4
Z9 4
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD APR
PY 2024
VL 79
IS 4
DI 10.1016/j.jvs.2023.11.043
EA MAR 2024
PG 14
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA QC4M5
UT WOS:001218667300001
PM 38042513
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Scarpa, C
   Grigatti, M
   Rizzato, S
   Crema, A
   Vindigni, V
   Bassetto, F
AF Scarpa, Carlotta
   Grigatti, Martina
   Rizzato, Sandro
   Crema, Alberto
   Vindigni, Vincenzo
   Bassetto, Franco
TI Novel Foam Dressing With Through Holes and Negative Pressure Wound
   Therapy With Instillation and Dwell Time: A Retrospective Cohort Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; NPWTi-d; NPWT with instillation and
   dwell time; foam dressing; ROCF-CC; ROCF-V
AB Background. NPWTi-d of a topical wound solution has been shown to benefit healing in a variety of wound types. This therapy has traditionally been applied via a standard ROCF-V. In 2017, a new ROCF-CC was introduced at the practice of the authors of the current manuscript for adjunctive management of patients with wounds with thick exudate and/or nonviable tissue and in cases in which surgical debridement is not available or not appropriate. Objective. To compare the efficacy of NPWTi-d with ROCF-CC dressing (treatment) vs NPWTi-d with ROCF-V dressing (control). Materials and Methods. An observational retrospective cohort study of hospital records of patients with VLUs treated with NPWTi-d who received ROCF-CC dressings (n = 11) vs standard ROCF-V dressings (n = 11) was conducted. NPWTi-d was chosen to promote wound healing in VLUs that were not fully responsive to advanced dressings and/or compression bandage. Solution dwell time was 10 minutes, followed by 2.5 -hour NPWT cycles at -125 mm Hg. Dressings were changed every 72 hours. Results. Overall, mean +/- SD duration of therapy and hospital length of stay were shorter in the treatment group vs the control group (duration of therapy, 8.63 days +/- 7.05 vs 11.72 days +/- 17.41, respectively; P = .05, and length of stay, 9.9 days +/- 2.98 vs 12.81 days +/- 4.26, respectively; P = .08), but these differences were not statistically significant. Mean wound area reduction was greater in the treatment group than in the control group (14.63 cm 2 +/- 13.24 and 10.72 cm 2 +/- 14.06, respectively; P = .51), but this was not significant. Conclusion. ROCF-CC dressings were a useful tool in assisting wound bed preparation and reducing time to skin graft closure in this series of complex VLUs.
C1 [Scarpa, Carlotta; Grigatti, Martina; Rizzato, Sandro; Crema, Alberto; Vindigni, Vincenzo; Bassetto, Franco] Univ Padua, Plast Surg Inst, Padua, Italy.
   [Scarpa, Carlotta] Inst Plast Surg, Neurosci, Via Giustinani 2, I-35100 Padua, Italy.
C3 University of Padua
RP Scarpa, C (通讯作者)，Inst Plast Surg, Neurosci, Via Giustinani 2, I-35100 Padua, Italy.
EM carlotta.scarpa@unipd.it
RI Vindigni, Vincenzo/K-5059-2016; Scarpa, Carlotta/HJG-7233-2022
CR Bennison LR, 2017, WOUND PRACT RES, V25, P63
   Faust E, 2021, PLAST RECONSTR SURG, V147, p16S, DOI 10.1097/PRS.0000000000007607
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   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
NR 15
TC 3
Z9 3
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2024
VL 36
IS 3
BP 67
EP 72
DI 10.25270/wnds/23081
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QM3U1
UT WOS:001221259200002
PM 38684120
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Vincent, CN
   Venkatesan, AS
   Rai, D
   Muthuswamy, AKS
AF Vincent, Chandan Noel
   Venkatesan, Aakash Sethuraman
   Rai, Dinakar
   Muthuswamy, Arvind Kumar Salem
TI The Use of Custom-Made Negative Pressure Wound Therapy to Manage Acute
   Wound Infections: A Retrospective Outcomes Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE infected wound; lower limb; negative pressure wound therapy; secondary
   suture; split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE; STERNAL OSTEOMYELITIS; DEVICE
AB Background. NPWT has been used to treat various wounds. Scant evidence exists on the use of custom-made NPWT for infected wounds. NPWT dressings promote wound healing by increasing local blood flow and antibiotic concentration, and by removing exudates from the wound. Objective. To report the use of custom-made NPWT dressings to manage complex infected wounds of the lower limb. Materials and Methods. The authors retrospectively reviewed the records of 43 patients with complex infected wounds of the lower limb treated with debridement and low-cost, custom-made NPWT dressing connected to wall suction from January 1, 2018 to December 31, 2020, at PSG Medical College Hospital, Coimbatore, India. Results. A total of 43 patients with infected wounds of the lower limb were treated with the custom-made NPWT dressings. Second -look debridement was required in 5 patients. An average of 5 dressing changes were required for optimal wound granulation, with 23% of patients (n = 10) requiring secondary suturing and 62% (n = 27) requiring STSG for definitive coverage of the wound. Healing by secondary intention was achieved in 6 patients. The average duration from the start of therapy until the wound was ready for coverage (STSG or secondary suturing) was 2.5 weeks (range, 1-5 weeks), with an average time to complete wound healing of 5 weeks (range, 3-7 weeks). The most common wound isolate was Staphylococcus aureus (60%). No complications occurred. Conclusions. Custom-made NPWT dressings are safe to use in complex infected lower limb wounds. These dressings keep the wound dry and promote healing. Wound debridement followed by NPWT combined with antibiotic therapy can act synergistically to promote wound healing and control infection.
C1 [Vincent, Chandan Noel] Manchester Royal Infirm Hosp, Orthopaed, Manchester, England.
   [Venkatesan, Aakash Sethuraman] NHS Wales Aneurin Bevan Univ Hlth Board, Newport, Wales.
   [Rai, Dinakar; Muthuswamy, Arvind Kumar Salem] PSG Inst Med Sci & Res, Coimbatore, India.
   [Vincent, Chandan Noel] Manchester Royal Infirm, Orthopaed, Oxford Rd, Manchester M13 9WL, England.
C3 University of Manchester
RP Vincent, CN (通讯作者)，Manchester Royal Infirm, Orthopaed, Oxford Rd, Manchester M13 9WL, England.
EM chandannoel@gmail.com
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
   Bhat Towseef Ahmad, 2019, J Clin Orthop Trauma, V10, P195, DOI [10.1016/j.jcot.2017.11.010, 10.1016/j.jcot.2017.11.010]
   Bihariesingh VJ, 2004, ARCH ORTHOP TRAUM SU, V124, P73, DOI 10.1007/s00402-003-0615-8
   Cowan KN, 2005, ANN THORAC SURG, V80, P2205, DOI 10.1016/j.athoracsur.2005.04.005
   De Pellegrin L, 2023, INT WOUND J, V20, P2402, DOI 10.1111/iwj.14072
   European Wound Management Association (EWMA), 2006, Position Document: Management of wound infection
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Gabriel A, 2021, PLAST RECONSTR SURG, V147, p68S, DOI 10.1097/PRS.0000000000007614
   Gill NA, 2011, WOUNDS, V23, P84
   Glass GE, 2017, J PLAST RECONSTR AES, V70, P1028, DOI 10.1016/j.bjps.2017.05.027
   Goss S G, 2012, J Am Coll Clin Wound Spec, V4, P74, DOI 10.1016/j.jccw.2014.02.001
   International Wound Infection Institute, Wound infection in clinical practice: principles of best practice
   Jones Daniel de Alcântara, 2016, Rev. bras. ortop., V51, P646, DOI [10.1016/j.rboe.2016.10.014, 10.1016/j.rboe.2016.10.014]
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   Lee R, 2018, EUR SPINE J, V27, P2536, DOI 10.1007/s00586-018-5612-2
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   Liu DH, 2014, CELL BIOCHEM BIOPHYS, V70, P539, DOI 10.1007/s12013-014-9953-0
   Lo Torto F, 2017, INT WOUND J, V14, P909, DOI 10.1111/iwj.12725
   Mohsin M, 2017, INDIAN J PLAST SURG, V50, P43, DOI 10.4103/ijps.IJPS_196_16
   Moog P, 2021, J WOUND CARE, V30, P604, DOI 10.12968/jowc.2021.30.8.604
   Patmo ASP, 2014, ADV WOUND CARE, V3, P383, DOI 10.1089/wound.2013.0510
   Rashid HU, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9464
   Salazard B, 2008, J PLAST RECONSTR AES, V61, P302, DOI 10.1016/j.bjps.2007.05.004
   Sansone F, 2011, J CARDIAC SURG, V26, P600, DOI 10.1111/j.1540-8191.2011.01336.x
   Scholl L, 2004, J CARDIAC SURG, V19, P453, DOI 10.1111/j.0886-0440.2004.05002.x
   Tarzia V, 2014, INTERACT CARDIOV TH, V19, P70, DOI 10.1093/icvts/ivu101
   Vaidhya N, 2015, INDIAN J SURG, V77, pS525, DOI 10.1007/s12262-013-0907-3
NR 27
TC 0
Z9 0
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2024
VL 36
IS 3
BP 90
EP 94
DI 10.25270/wnds/23102
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QM3U1
UT WOS:001221259200004
PM 38684124
DA 2026-07-24
ER
PT J
AU Hauge, T
   Dretvik, T
   Johnson, E
   Mala, T
AF Hauge, Tobias
   Dretvik, Thomas
   Johnson, Egil
   Mala, Tom
TI Treatment of anastomotic leakage following Ivor Lewis esophagectomy-10
   year experience from a Nordic center
SO DISEASES OF THE ESOPHAGUS
LA English
DT Article
DE anastomotic leakage; bronchial fistula; esophagectomy; negative-pressure
   wound therapy; stent
ID RISK-FACTORS; COMPLICATIONS; CONSENSUS; IMPACT
AB Anastomotic leakage (AL) is a dreaded complication following esophageal resection. No clear consensus exist for the optimal handling of this severe complication. The aim of this study was to describe the treatment outcome following AL. We conducted a retrospective cross-sectional study including all patients with AL operated with Ivor Lewis esophagectomy from 2010 to 2021 at Oslo University Hospital, Norway. 74/526 (14%) patients had AL. Patient outcomes were analyzed and categorized according to main AL treatment strategy; stent (54%), endoscopic vacuum therapy and stent (EVT + stent) (19%), nasogastric tube and antibiotics (conservative) (16%), EVT (8%) and by other endoscopic means (other) (3%). One patient had surgical debridement of the chest cavity. In 66 patients (89%), the perforation healed after median 27 (range: 4-174) days. Airway fistulation was observed in 11 patients (15%). Leak severity (ECCG) was associated with development of airway fistula (P = 0.03). The median hospital and intensive care unit stays were 30 (range: 12-285) and 9 (range: 0-60) days. The 90-days mortality among patients with AL was 5% and at follow up, 13% of all deaths were related to AL. AL closure rates were comparable across the groups, but longer in the EVT + stent group (55 days vs. 29.5 days, P = 0.04). Thirty-two percent developed a symptomatic anastomotic stricture within 12 months. Conclusion: The majority of AL can be treated endoscopically with preservation of the conduit and the anastomosis. We observed a high number of AL-associated airway fistulas.
C1 [Hauge, Tobias; Dretvik, Thomas; Johnson, Egil; Mala, Tom] Oslo Univ Hosp, Dept Pediat & Gastrointestinal Surg, Ulleval, Norway.
   [Johnson, Egil; Mala, Tom] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Hauge, Tobias] Oslo Univ Hosp, Dept Pediat & Gastrointestinal Surg, POB 4956, N-0424 Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo
RP Hauge, T (通讯作者)，Oslo Univ Hosp, Dept Pediat & Gastrointestinal Surg, POB 4956, N-0424 Oslo, Norway.
EM tobiha@ous-hf.no
RI Mala, Tom/J-5418-2019
OI Mala, Tom/0000-0003-3058-4775
CR Bartella I, 2023, LANGENBECK ARCH SURG, V408, DOI 10.1007/s00423-023-03001-4
   Eichelmann AK, 2021, J GASTROINTEST SURG, V25, P2447, DOI 10.1007/s11605-021-04955-w
   Fabbi M, 2021, DIS ESOPHAGUS, V34, DOI 10.1093/dote/doaa039
   Hauge T, 2022, DIS ESOPHAGUS, V35, DOI 10.1093/dote/doab061
   Hauge T, 2020, ACTA ONCOL, V59, P859, DOI 10.1080/0284186X.2020.1750694
   Hayami M, 2021, Dis Esophagus, V34
   Hwang JJ, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003416
   Ishikawa Y, 2022, DIS ESOPHAGUS, V35, DOI 10.1093/dote/doab079
   Klevebro F, 2019, ANN SURG ONCOL, V26, P2864, DOI 10.1245/s10434-019-07478-6
   Lange J, 2023, SURG ENDOSC, V37, P3657, DOI 10.1007/s00464-023-09861-7
   Low DE, 2015, ANN SURG, V262, P286, DOI 10.1097/SLA.0000000000001098
   Markar S, 2015, ANN SURG, V262, P972, DOI 10.1097/SLA.0000000000001011
   Mboumi IW, 2019, SURG CLIN N AM, V99, P501, DOI 10.1016/j.suc.2019.02.011
   Messager M, 2017, EJSO-EUR J SURG ONC, V43, P258, DOI 10.1016/j.ejso.2016.06.394
   Na BB, 2023, ANN THORAC SURG, V115, P1257, DOI 10.1016/j.athoracsur.2023.01.026
   Persson S, 2017, DIS ESOPHAGUS, V30, DOI 10.1093/dote/dox108
   Persson S, 2016, ENDOSC INT OPEN, V4, pE420, DOI 10.1055/s-0042-102878
   Rausa E, 2018, DIS ESOPHAGUS, V31, DOI 10.1093/dote/doy060
   Rockwood K, 2005, CAN MED ASSOC J, V173, P489, DOI 10.1503/cmaj.050051
   Schorsch T, 2013, SURG ENDOSC, V27, P2040, DOI 10.1007/s00464-012-2707-4
   Scognamiglio P, 2022, BMC SURG, V22, DOI 10.1186/s12893-022-01764-z
   Tavares G., 2021, Dis Esophagus, V34
   Ubels S, 2023, EJSO-EUR J SURG ONC, V49, P974, DOI 10.1016/j.ejso.2023.01.010
   Ubels S, 2022, BJS-BRIT J SURG, V109, P864, DOI 10.1093/bjs/znac226
   von Elm E, 2007, PLOS MED, V4, P1623, DOI [10.1371/journal.pmed.0040296, 10.1371/journal.pmed.0040297]
NR 25
TC 7
Z9 7
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1120-8694
EI 1442-2050
J9 DIS ESOPHAGUS
JI Dis. Esophagus
PD MAY 14
PY 2024
VL 37
IS 9
DI 10.1093/dote/doae040
EA MAY 2024
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA E0Q0O
UT WOS:001222279800001
PM 38745429
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Davey, JS
   Chong, WL
   Fountain, J
   Heller, J
   Sul, R
   Jermyn, K
   Michelsen, J
   Eckart, LH
AF Davey, Jack S.
   Chong, Wye Li
   Fountain, Jake
   Heller, Jane
   Sul, Rui
   Jermyn, Kieri
   Michelsen, Jacob
   Eckart, Louisa Ho
TI In vitro evaluation of a hybrid negative pressure system for wound
   therapy
SO VETERINARY SURGERY
LA English
DT Article
ID MICROVASCULAR BLOOD-FLOW; VACUUM-ASSISTED CLOSURE; INTERMITTENT
AB ObjectiveThe objective of this study was to assess whether negative pressure could be maintained accurately and repeatably with a wall-suction-based hybrid negative pressure wound therapy (h-NPWT) system by comparing it with a commercial negative pressure wound therapy (NPWT) device.Study designIn vitro experimental study.MethodsA commercial NPWT device (control) and three h-NPWT devices, with 0, 3, and 6 meters of additional tubing using the hospital-wall suction (groups 1, 2, and 3 respectively), were applied sequentially to a commercial NPWT dressing on a silicone skin substrate and set to run at a continuous pressure of -125 mmHg. The pressure within the wound space was monitored at 10 second intervals for 24 h. The process was repeated five times for each group.ResultsThe commercial NPWT device produced an average pressure variance of 3.02 mmHg, and the h-NPWT produced average variances of 4.38, 4.24 and 4.20 mmHg for groups 1, 2 and 3, respectively. All groups produced an average pressure within 0.15 mmHg of -125 mmHg over the 24-hour period, and the h-NPWT systems produced the smallest range with all values remaining within a +/- 5% variation from -125 mmHg.ConclusionThe h-NPWT system achieved negative pressures that were comparable to those of a commercial control NPWT device. The addition of tubing between the skin substrate and the canister did not affect the pressure applied at the wound site.Clinical significanceThe h-NPWT device tested in this study can be considered as an alternative for negative wound therapy when a commercial device cannot be used.
C1 [Davey, Jack S.; Chong, Wye Li; Sul, Rui; Jermyn, Kieri; Michelsen, Jacob; Eckart, Louisa Ho] Anim Referral Hosp Canberra, 364 Fairbairn Ave, Pialligo, ACT 2609, Australia.
   [Davey, Jack S.; Fountain, Jake; Heller, Jane] Charles Sturt Univ, Fac Sci & Hlth, Sch Agr Environm & Vet Sci, Wagga Wagga, NSW, Australia.
C3 Charles Sturt University
RP Davey, JS (通讯作者)，Anim Referral Hosp Canberra, 364 Fairbairn Ave, Pialligo, ACT 2609, Australia.
EM j.davey@arhvets.com
RI Michelsen, Jacob/KBC-6638-2024; Fountain, Jake/JVE-2235-2024; Heller,
   Jane/H-9596-2016
OI Michelsen, Jacob/0009-0000-5567-9637; Sul, Rui/0009-0001-8339-8039;
   Davey, Jack/0000-0001-7302-5215; Ho Eckart, Louisa/0009-0003-7428-7067;
   Fountain, Jake/0000-0002-9416-5900; Heller, Jane/0000-0003-3993-0160;
   Chong, Wye Li/0000-0001-6697-3073
CR 3M, SENSATRAC PAD 3M SCI
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   Banwell P E, 1999, J Wound Care, V8, P79
   Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
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   Borgquist O, 2011, OSTOMY WOUND MANAG, V57, P44
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
   Borgquist O, 2010, OSTOMY WOUND MANAG, V56, P60
   Borgquist O, 2010, PLAST RECONSTR SURG, V125, P502, DOI 10.1097/PRS.0b013e3181c82e1f
   Bui TD, 2006, AM J SURG, V192, P235, DOI 10.1016/j.amjsurg.2006.01.013
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   Perez D, 2010, AM J SURG, V199, P14, DOI 10.1016/j.amjsurg.2008.12.029
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   Zannis J, 2009, ANN PLAS SURG, V62, P407, DOI 10.1097/SAP.0b013e3181881b29
NR 22
TC 0
Z9 1
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD AUG
PY 2024
VL 53
IS 6
BP 1093
EP 1101
DI 10.1111/vsu.14101
EA MAY 2024
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA C7I8W
UT WOS:001222530600001
PM 38747194
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Wenzel, PA
   Rizk, MP
   Michael, A
   Yin, T
   Andrews, BT
AF Wenzel, Piper A.
   Rizk, Michael P.
   Michael, Alexander
   Yin, Terry
   Andrews, Brian T.
TI Assessment of Early and Late Management of Submental Gunshot Wounds
SO FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
LA English
DT Article
DE Craniofacial reconstruction; craniofacial trauma; facial gunshot wounds;
   penetrating trauma; microvascular reconstruction; free tissue transfer
ID INJURIES; RECONSTRUCTION
AB Background: Management of submental gunshot wounds is becoming more common and requires complex surgical decisions. Objective: Compare outcomes of early and definitive reconstructive techniques following submental gunshot wounds. Methods: Retrospective chart review evaluated subjects who sustained a self-inflicted submental gunshot. The incidence of complications requiring unplanned operations was compared for early management techniques of skin/soft tissue, bone, and mucosal lining and definitive reconstructive techniques using Fisher's or Pearson Chi-square exact test with p <= 0.05 considered statistically significant. Results: The total of 27 patients were included. Early techniques included skin = primary soft tissue closure (n = 19) versus wound vacuum-assisted closure (n = 8); mandible = open reduction internal fixation (ORIF) (n = 19) versus external fixation (n = 8); and oral mucosal lining = primary mucosal closure (n = 20) versus dermal substitute (n = 7). Definitive management included ORIF (n = 10, 37%), ORIF with bone grafting (n = 8, 30%), and microvascular free-flap (n = 9, 33%). The incidence of complications requiring unplanned operation when using dermal substitutes for mucosal lining management was statistically higher than primary closure (p < 0.001); otherwise the complication rates of surgical techniques were equivalent. Conclusion: Several surgical decisions and techniques can be utilized at the time of early and definitive management of submental gunshot wounds. Only the use of dermal substitutes for mucosal lining is associated with a significantly higher rate of unplanned operation.
C1 [Wenzel, Piper A.; Rizk, Michael P.; Michael, Alexander; Yin, Terry; Andrews, Brian T.] Univ Iowa Hosp & Clin, Dept Otolaryngol, 200 Hawkins Dr, Iowa, IA 52242 USA.
C3 University of Iowa
RP Andrews, BT (通讯作者)，Univ Iowa Hosp & Clin, Dept Otolaryngol, 200 Hawkins Dr, Iowa, IA 52242 USA.
EM brian-andrews@uiowa.edu
OI Wenzel, Piper/0009-0001-3040-0908
CR Alpert B, 2009, ORAL MAXIL SURG CLIN, V21, P185, DOI 10.1016/j.coms.2008.12.002
   Chrcanovic BR, 2013, ORAL MAXILLOFAC SURG, V17, P95, DOI 10.1007/s10006-012-0349-2
   Demetriades D, 1998, J TRAUMA, V45, P39, DOI 10.1097/00005373-199807000-00007
   Ellis E III, 2003, J ORAL MAXIL SURG, V61, P861, DOI 10.1016/S0278-2391(03)00249-0
   Fowler KA, 2015, PREV MED, V79, P5, DOI 10.1016/j.ypmed.2015.06.002
   Gonzalez-Castro J, 2016, LARYNGOSCOPE, V126, P340, DOI 10.1002/lary.25388
   Heffern E, 2021, J CRANIOFAC SURG, V32, P2487, DOI 10.1097/SCS.0000000000007884
   Khatib B, 2017, FACIAL PLAST SURG CL, V25, P563, DOI 10.1016/j.fsc.2017.06.007
   Li Z, 2011, J CRANIO MAXILL SURG, V39, P296, DOI 10.1016/j.jcms.2010.04.009
   McCann AC, 2019, LARYNGOSCOPE, V129, P1081, DOI 10.1002/lary.27406
   Nevil C, 2021, FACE-THOUSAND OAKS, V2, P329, DOI [10.1177/27325016211053351, 10.1177/27325016211053351]
   Newlands SD, 2003, OTOLARYNG HEAD NECK, V129, P239, DOI 10.1016/S0194-5998(03)00481-9
   Niu XG, 2020, BRIT J ORAL MAX SURG, V58, P324, DOI 10.1016/j.bjoms.2019.12.012
   Peleg M, 2010, J CRANIOFAC SURG, V21, P1257, DOI 10.1097/SCS.0b013e3181e2065b
   Rana M, 2014, INJURY, V45, P206, DOI 10.1016/j.injury.2012.09.021
   Wang WJ, 2015, INT J CLIN EXP MED, V8, P1427
   wisqars, WISQARS fatal and nonfatal injury reports
NR 17
TC 1
Z9 2
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2689-3614
EI 2689-3622
J9 FACIAL PLAST SURG AE
JI Facial Plast. Surg. Aesthet. Med.
PD NOV 1
PY 2024
VL 26
IS 6
BP 786
EP 792
DI 10.1089/fpsam.2023.0359
EA MAY 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA N4O7K
UT WOS:001222676700001
PM 38747171
DA 2026-07-24
ER
PT J
AU Achiti, A
   Zenati, N
   Seinturier, C
   Cracowski, JL
   Blaise, S
AF Achiti, Alexandru
   Zenati, Nora
   Seinturier, Christophe
   Cracowski, Jean-Luc
   Blaise, Sophie
TI Negative pressure wound therapy with instillation and dwell time in
   debridement of fibrinous leg ulcers
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE chronic; debridement; hard-to-heal; negative pressure wound therapy;
   negative pressure wound therapy with instillation and dwell time; NPWT;
   NPWTi-d; wound; wound care; wound dressing; wound healing
AB Objective: In conjunction with appropriate wound care, negative pressure wound therapy with instillation and dwell time (NPWTi-d) may be used as an adjunct therapy for acute or hard -to -heal (chronic) wounds, especially when infected. However, there are very few data on the use of NPWTi-d in the treatment of fibrinous wounds that are difficult to debride mechanically. The main objective of this study was to describe changes in the fibrin area of such wounds, before and after treatment with NPWTi-d. Method: This was a monocentric, observational, prospective pilot study evaluating the NPWTi-d medical device. Eligible patients included in the study were those with hard -to -heal lower limb ulcers who had previously undergone unsuccessful specific debridement treatment for their wound, with failure of manual mechanic debridement for at least six weeks' duration, and whose wounds had a fibrinous surface area of >70% of the total wound surface area. The primary endpoint was the difference in the percentage of fibrinous surface area before and after treatment. Results: A total of 14 patients who received treatment for lower limb ulcers between October 2017 and August 2019 were included in the study. There was a significant shrinkage rate of the fibrinous wound surface between the start and end of treatment (83.6 +/- 14.5% and 32.2 +/- 19.7%, respectively; p<0.001). Conclusion: This study showed a significant decrease in fibrin area in wounds treated with NPWTi-d, with good tolerance. We believe that NPWTi-d has its place in the multidisciplinary management of patients with hard -to -heal ulcers. Additional randomised studies are required to confirm these findings. Declaration of interest: The authors have no conflicts of interest.
C1 [Achiti, Alexandru; Zenati, Nora; Blaise, Sophie] Ctr Hosp & Univ Grenoble Alpes, Serv Med Vasc, F-38000 Grenoble, France.
   [Seinturier, Christophe; Cracowski, Jean-Luc; Blaise, Sophie] Univ Grenoble Alpes, Inserm, HP2, F-38000 Grenoble, France.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   CHU Grenoble Alpes; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Communaute Universite Grenoble Alpes; Universite
   Grenoble Alpes (UGA)
RP Blaise, S (通讯作者)，Ctr Hosp & Univ Grenoble Alpes, Serv Med Vasc, F-38000 Grenoble, France.; Blaise, S (通讯作者)，Univ Grenoble Alpes, Inserm, HP2, F-38000 Grenoble, France.
EM SBlaise@chu-grenoble.fr
RI Cracowski, Jean-Luc/M-6946-2014; Blaise, Sophie/AAS-2389-2020
OI Cracowski, Jean-Luc/0000-0003-0787-1469; 
CR Back DA, 2013, INT WOUND J, V10, P32, DOI 10.1111/iwj.12183
   Chowdhry SA, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002087
   Eckstein FM, 2019, J CRANIO MAXILL SURG, V47, P389, DOI 10.1016/j.jcms.2018.12.006
   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
   Goss S G, 2012, J Am Coll Clin Wound Spec, V4, P74, DOI 10.1016/j.jccw.2014.02.001
   Haute Autorite de Sante (HAS), 2013, Negative pressure wound treatment (NPWT): specific and limited uses-GOALS sheet
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2013, PLAST RECONSTR SURG, V132, P1569, DOI 10.1097/PRS.0b013e3182a80586
   Lehner B, 2011, INT ORTHOP, V35, P1415, DOI 10.1007/s00264-011-1274-y
   Lévy E, 2001, J MAL VASCUL, V26, P39
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   Saeg F, 2021, PLAST RECONSTR SURG, V148, p601E, DOI 10.1097/PRS.0000000000008331
   Saeg F, 2021, PLAST RECONSTR SURG, V148, P226, DOI 10.1097/PRS.0000000000008061
   Uoya Yuichiro, 2019, Wounds, V31, pE61
   Yang CK, 2015, J VASC SURG, V61, P995, DOI 10.1016/j.jvs.2014.11.076
NR 16
TC 4
Z9 5
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2024
VL 33
IS 3
BP 166
EP 170
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QU9D3
UT WOS:001223490900003
PM 38451785
DA 2026-07-24
ER
PT J
AU Zhu, W
   Shu, ZQ
   Song, HP
AF Zhu, Wei
   Shu, Ziqin
   Song, Huapei
TI A rare case of a hard-to-heal ulcer caused by pulmonary Nocardia
   infection
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE debridement; nocardia; pulmonary infection; vacuum sealing drainage;
   wound; wound care; wound dressing; wound healing; hard-to-heal wound
ID WOUNDS
AB Nocardiosis is an acute purulent or granulomatous disease caused by Nocardia spp. infection that commonly invades the lungs and central nervous system. Hard -to -heal wounds caused by Nocardia spp. infection are rare. A 63 -year -old female patient underwent puncture biopsy due to a mass in the right lung. Subsequently, dermal ulceration occurred on her back at the biopsy site, with no improvement following treatment at multiple hospitals. After admission to our department, bacterial culture of sputum and discharge from the deep wound sinus revealed Nocardia asteroides infection. The treatment regimen was developed by a multidisciplinary team at our department. The patient underwent debridement and vacuum sealing drainage (VSD) and was administered imipenem. The wound was then sealed by local flap transfer. The patient was discharged from the hospital after the wound had healed and continued to take minocycline for 2 months. At 3 months post -discharge, the symptoms of lung infection had resolved. Nocardiosis mainly affects the lungs, and its clinical symptoms are similar to those of pulmonary tuberculosis. Nocardia infections can extend to the chest wall and form abscesses or cellulitis. For hard -to -heal wounds caused by Nocardia spp., local debridement combined with systemic anti -infective therapy should be applied. In this case study, the diagnosis of pulmonary and wound nocardiosis was confirmed based on clinical manifestations, imaging, aetiological investigation and pathology. The treatment regimen was debridement combined with VSD, as well as a full course of antibiotics. The optimal treatment regimen for hard -to -heal wounds caused by Nocardia spp. includes effective debridement combined with VSD and long -course antibiotic therapy, which can improve the cure rate.
C1 [Zhu, Wei; Song, Huapei] Army Med Univ, Third Mil Med Univ, Southwest Hosp, Inst Burn Res,State Key Lab Trauma Burn & Combine, Chongqing, Peoples R China.
C3 Army Medical University
RP Song, HP (通讯作者)，Army Med Univ, Third Mil Med Univ, Southwest Hosp, Inst Burn Res,State Key Lab Trauma Burn & Combine, Chongqing, Peoples R China.
EM shpmajor@hotmail.com
RI 朱, 玮/HKN-1733-2023
CR Acuner B, 2021, WOUND MANAG PREV, V67, P33, DOI 10.25270/wmp.2021.5.3339
   Derungs T, 2021, LANCET INFECT DIS, V21, pE334, DOI 10.1016/S1473-3099(20)30920-8
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   Gabriel A, 2021, PLAST RECONSTR SURG, V147, p68S, DOI 10.1097/PRS.0000000000007614
   Goldberg SR, 2020, SURG CLIN N AM, V100, P681, DOI 10.1016/j.suc.2020.05.001
   Han G, 2017, ADV THER, V34, P599, DOI 10.1007/s12325-017-0478-y
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Luo N, 2021, BMC INFECT DIS, V21, DOI 10.1186/s12879-020-05673-5
   Lutfor AB, 2021, INT J INFECT DIS, V110, P272, DOI 10.1016/j.ijid.2021.07.028
   Lynch JP III, 2020, SEMIN RESP CRIT CARE, V41, P538, DOI 10.1055/s-0040-1708816
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   Mehrabadi SM, 2020, ETHIOP J HEALTH SCI, V30, P293, DOI 10.4314/ejhs.v30i2.17
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   Ott SR, 2019, INT J INFECT DIS, V81, P140, DOI 10.1016/j.ijid.2018.12.010
   Xue X, 2021, INT WOUND J, V18, P639, DOI 10.1111/iwj.13565
   Zhou KH, 2015, MED HYPOTHESES, V85, P399, DOI 10.1016/j.mehy.2015.06.017
NR 17
TC 0
Z9 0
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2024
VL 33
IS 3
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QU9D3
UT WOS:001223490900006
DA 2026-07-24
ER
PT J
AU Zhu, J
   Yan, L
   Hu, R
   Yang, CB
   Wu, MZ
   An, Y
   Li, SQ
AF Zhu, Jin
   Yan, Li
   Hu, Rui
   Yang, Chunbao
   Wu, Mingzheng
   An, Ying
   Li, Shanqing
TI Artificial dermis combined with negative pressure wound therapy and
   plateletrich plasma to treat traumatic wounds: a retrospective study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE artificial dermis; negative pressure wound therapy; platelet-rich
   plasma; split-thickness skin grafting; wound; wound care; wound
   dressing; wound healing; wound repair
ID RICH PLASMA; INJURIES; RECONSTRUCTION; INSTILLATION; EXPERIENCE; DEFECTS
AB Objective: The reconstruction of complex soft tissue defects with exposure of bones and tendons represents an increasing challenge in wound care, especially in large extremity wounds. The aim of this study was to detect the clinical efficacy of combined use of negative pressure wound therapy (NPWT), artificial dermis (ADM), platelet -rich plasma (PRP) and split -thickness skin grafting (STSG) in the reconstruction of large traumatic extremity skin defects. Method: In this study, eight cases were treated with combined therapies for repairing complex extremity wounds and the results were reviewed retrospectively. After surgical debridement, all wounds received ADM, PRP and delayed STSG, which were all aided with NPWT. Results: The patients consisted of five males and three females, with a mean age of 44 years. A total of six lower extremity wounds were located at the foot/ankle, with exposed tendon in five, bone exposure in three and both in two. Of the group, two patients had exposed tendon on arm/hand wounds. The size of wounds and ADM averaged 126cm(2) and 42.3cm(2) , respectively. ADM was used to cover the exposed bone or tendon, the granulation and muscular tissue were covered with vacuum sealing drainage (VSD) directly, for NPWT. The survival rate of ADM averaged 98.9%. The average time for survival of ADM was 12.8 days and the mean uptake of autologous skin graft was 93.5%. Only one patient received repeated skin grafts. All patients achieved successful healing and reported no complications. The mean length of hospital stay was 36.1 days. Conclusion: Our study revealed that ADM in conjunction with NPWT, PRP and STSG could be used for repairing large traumatic extremity wounds. Wound closure was achieved without flaps, the aesthetic and functional outcomes were acceptable, and only one patient developed a 35% loss of skin graft.
C1 [Zhu, Jin; Yan, Li; Hu, Rui; Yang, Chunbao; Wu, Mingzheng; An, Ying; Li, Shanqing] Wuhan Fourth Hosp, Dept Orthopaed, Wuhan, Peoples R China.
RP Yan, L (通讯作者)，Wuhan Fourth Hosp, Dept Orthopaed, Wuhan, Peoples R China.
EM swyanli666@hotmail.com
CR Brongo S, 2014, CASE REP SURG, V2014, DOI 10.1155/2014/783812
   Quintero EC, 2018, J WOUND CARE, V27, pS12, DOI 10.12968/jowc.2018.27.Sup2.S12
   Cervantes J, 2018, SKIN APPENDAGE DISOR, V4, P1, DOI 10.1159/000477671
   Cottone G, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57121367
   De Francesco F, 2020, J INT MED RES, V48, DOI 10.1177/0300060520945508
   Enescu DM, 2020, INJURY, V51, pS9, DOI 10.1016/j.injury.2020.03.027
   Eo S, 2011, INT WOUND J, V8, P261, DOI 10.1111/j.1742-481X.2011.00780.x
   Gabriel A, 2021, PLAST RECONSTR SURG, V147, p68S, DOI 10.1097/PRS.0000000000007614
   Gupta S, 2016, INT WOUND J, V13, P159, DOI 10.1111/iwj.12452
   Hersant B, 2019, STEM CELLS INT, V2019, DOI 10.1155/2019/1234263
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
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   Riccio M, 2019, STEM CELLS INT, V2019, DOI 10.1155/2019/5043518
   Robert N, 2017, ORTHOP TRAUMATOL-SUR, V103, pS99, DOI 10.1016/j.otsr.2016.04.018
   Sakai G, 2017, INJURY, V48, P137, DOI 10.1016/j.injury.2016.10.026
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   van der Veen VC, 2010, BURNS, V36, P305, DOI 10.1016/j.burns.2009.07.012
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   Zhang WH, 2019, TISSUE ENG PART B-RE, V25, P225, DOI [10.1089/ten.teb.2018.0309, 10.1089/ten.TEB.2018.0309]
NR 28
TC 1
Z9 1
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2024
VL 33
IS 3
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QU9D3
UT WOS:001223490900007
DA 2026-07-24
ER
PT J
AU Flavia, P
   Beatrice, P
   Marco, RC
   Giancarlo, I
   Federico, L
   Diego, R
   Stefano, G
   Daniele, D
AF Flavia, Petrucci
   Beatrice, Perciballi
   Marco, Rivano Capparuccia
   Giancarlo, Iaiani
   Federico, Lo Torto
   Diego, Ribuffo
   Stefano, Gumina
   Daniele, De Meo
TI Compassionate use of cefiderocol in a complex case of extensively
   drug-resistant Acinetobacter baumannii fracture-related
   infection: a comprehensive approach and multidisciplinary management
SO INFECTION
LA English
DT Article
DE Antimicrobial resistance; Fracture related infection; Tibia fracture;
   Acinetobacterbaumannii; Cefiderocol; Multidisciplinary
ID OSTEOMYELITIS; COLISTIN
AB Purpose Fracture-related infections (FRI) pose a difficult management problem, as they require numerous surgical interventions and extended antibiotic treatments, especially when a multidrug-resistant organism is involved, with a paucity of available literature that provides guidance. Results A 42 year-old male presents an open diaphyseal tibia and fibula fracture, complicated by soft tissue necrosis and infections caused by extensively drug-resistant Acinetobacter baumannii (XDR-Ab). Initially treated with a damage control external fixator, the patient underwent multiple surgical procedures, including radical debridement, negative pressure wound therapy, external fixator revisions and reconstructive surgery using a latissimus dorsi free flap. The emergence of colistin resistance in the Acinetobacter baumannii strain led to the compassionate use of cefiderocol, finally achieving clinical cure. Conclusions This case report is one of the firsts that highlights the potential efficacy of cefiderocol in treating challenging bone and joint infections sustained by XDR-Ab. The successful outcome also emphasizes the importance of a comprehensive, multidisciplinary approach in achieving favorable results in complex FRI.
C1 [Flavia, Petrucci] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy.
   [Flavia, Petrucci; Beatrice, Perciballi; Marco, Rivano Capparuccia; Giancarlo, Iaiani; Federico, Lo Torto; Diego, Ribuffo; Daniele, De Meo] Policlin Umberto I Hosp, MITO Infect Traumatol & Orthoped Surg Study Grp, Viale Policlin 155, I-00161 Rome, Italy.
   [Beatrice, Perciballi; Stefano, Gumina; Daniele, De Meo] Sapienza Univ Rome, Dept Anat Forens Med & Musculoskeletal Syst Sci, I-00161 Rome, Italy.
   [Federico, Lo Torto; Diego, Ribuffo] Univ Rome, Orthoped Policlin Umberto I Hosp Sapienza, Dept Gen Surg, Plast Surg Unit,Plast Surg, Viale Policlin 155, I-00161 Rome, Italy.
   [Marco, Rivano Capparuccia; Giancarlo, Iaiani] Policlin Umberto I Univ Hosp, Dept Internal Med Endocrine Metab Sci & Infect Dis, I-00161 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; University Hospital
   Sapienza Rome; Sapienza University Rome; Sapienza University Rome;
   Sapienza University Rome; University Hospital Sapienza Rome
RP Flavia, P (通讯作者)，Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy.; Flavia, P (通讯作者)，Policlin Umberto I Hosp, MITO Infect Traumatol & Orthoped Surg Study Grp, Viale Policlin 155, I-00161 Rome, Italy.
EM flavia.petrucci@uniroma1.it
RI ; De Meo, Daniele/AAU-1698-2020
OI PETRUCCI, FLAVIA/0009-0008-1715-9532; De Meo,
   Daniele/0000-0003-1914-5413
FU Universit degli Studi di Roma La Sapienza
FX No Statement Available
CR Alamarat ZI, 2020, ANTIMICROB AGENTS CH, V64, DOI 10.1128/AAC.01872-19
   [Anonymous], Antimicrobial Resistance Surveillance inEurope 2022-2020Data
   Bassetti M, 2021, LANCET INFECT DIS, V21, P226, DOI 10.1016/S1473-3099(20)30796-9
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   Dagher M, 2020, OPEN FORUM INFECT DI, V7, DOI 10.1093/ofid/ofaa150
   De Meo D, 2021, GELS-BASEL, V7, DOI 10.3390/gels7030126
   Depypere M, 2020, J ORTHOP TRAUMA, V34, P30, DOI 10.1097/BOT.0000000000001626
   Fily F, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-019-3741-9
   Harding CM, 2018, NAT REV MICROBIOL, V16, P91, DOI 10.1038/nrmicro.2017.148
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   Lee CR, 2017, FRONT CELL INFECT MI, V7, DOI 10.3389/fcimb.2017.00055
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   Ren YL, 2023, INT J SURG, V109, P2721, DOI 10.1097/JS9.0000000000000502
   Siebenbürger G, 2019, EUR J MED RES, V24, DOI 10.1186/s40001-019-0360-2
   Tiseo G, 2022, INT J ANTIMICROB AG, V60, DOI 10.1016/j.ijantimicag.2022.106611
   Zhanel GG, 2019, DRUGS, V79, P271, DOI 10.1007/s40265-019-1055-2
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NR 23
TC 2
Z9 4
U1 3
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8126
EI 1439-0973
J9 INFECTION
JI Infection
PD DEC
PY 2024
VL 52
IS 6
BP 2487
EP 2493
DI 10.1007/s15010-024-02294-x
EA MAY 2024
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA O5W9S
UT WOS:001223811600001
PM 38748180
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Tapking, C
   Panayi, A
   Haug, V
   Palackic, A
   Houschyar, KS
   Claes, KEY
   Kuepper, S
   Vollbach, F
   Kneser, U
   Hundeshagen, G
AF Tapking, C.
   Panayi, A.
   Haug, V.
   Palackic, A.
   Houschyar, K. S.
   Claes, K. E. Y.
   Kuepper, S.
   Vollbach, F.
   Kneser, U.
   Hundeshagen, G.
TI Use of the modified meek technique for the coverage of extensive burn
   wounds
SO BURNS
LA English
DT Article
DE Burn; Skin graft; Meek micrografting; Wound healing
ID 5 YEARS EXPERIENCE; MANAGEMENT
AB Introduction: Autologous split thickness skin grafting using meshing technique remains the preferred option for the management of deep dermal and full thickness burns. The limited donor site availability seen in patients with extensive burns, however, restricts use of the mesh grafting technique for skin expansion. Meek micrografting was developed to allow for greater expansion, and, therefore, more reliable treatment of extensive burns. This study aimed to present our outcomes using the Meek micrografting technique and identify risk factors for graft failure. Methods: A retrospective review of patients admitted to our large academic hospital who were treated with the Meek micrografting technique from 2013 to 2022 was conducted. Patient demographics, surgical characteristics and outcomes were reported. Regression analyses were performed to identify factors that influence graft take and reoperation rate. Results: A total of 73 patients with a mean age of 45.7 +/- 19.9 years and mean burn size of 60.0 +/- 17.8%TBSA, with 45.3 +/- 14.9% TBSA being third degree burns, received Meek transplantation. The mean graft take after removal of the pre-folded polyamide gauze at the tenth post-operative day was 75.8 +/- 14.7%. Pre-treatment with use of an allograft, longer waiting time between admission and Meek grafting and transplantation over a dermal matrix were identified as positive predictors for graft take, while age was established as a negative predictor. Conclusion: By examining the outcomes of the Meek micrografting technique in extensive burn wounds we identified that preconditioning of the wound bed, through allograft or negative pressure wound therapy application, positively correlates with improved outcomes, including higher graft take. At the same time, older age was seen to negatively correlate with graft take. Overall, Meek transplantation displays a favorable safety profile
C1 [Tapking, C.; Panayi, A.; Haug, V.; Palackic, A.; Vollbach, F.; Kneser, U.; Hundeshagen, G.] Heidelberg Univ, Dept Hand Plast & Reconstruct Surg, BG Unfallklin Ludwigshafen, Microsurg,Burn Ctr, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
   [Houschyar, K. S.] Univ Hosp Aachen, Dept Dermatol & Allergol, Aachen, Germany.
   [Claes, K. E. Y.] Ghent Univ Hosp, Burn Ctr, Dept Plast & Reconstruct Surg, Ghent, Belgium.
   [Kuepper, S.] Unfallkrankenhaus Berlin, Burns Ctr & Plast Surg, Berlin, Germany.
C3 Ruprecht Karls University Heidelberg; RWTH Aachen University; RWTH
   Aachen University Hospital; Ghent University; Ghent University Hospital
RP Hundeshagen, G (通讯作者)，Heidelberg Univ, Dept Hand Plast & Reconstruct Surg, BG Unfallklin Ludwigshafen, Microsurg,Burn Ctr, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
EM gabriel.hundeshagen@bgu-ludwigshafen.de
RI Panayi, Adriana/HHT-0513-2022; Claes, Karel/AAP-5220-2021
OI Panayi, Adriana/0000-0003-4053-9855; 
CR Almodumeegh A, 2017, INT WOUND J, V14, P601, DOI 10.1111/iwj.12650
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   Panayi AC, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001221
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   Riaz HM, 2020, J BURN CARE RES, V41, P1212, DOI 10.1093/jbcr/iraa069
   Rijpma D, 2022, BURNS, V48, P1287, DOI 10.1016/j.burns.2022.05.011
   Romanowski Kathleen S, 2022, Burns Open, V6, P57, DOI [10.1016/j.burnso.2022.01.002, 10.1016/j.burnso.2022.01.002]
   Schlottmann F, 2022, J PERS MED, V12, DOI 10.3390/jpm12122002
   Singer AJ, 2017, J BURN CARE RES, V38, pE605, DOI 10.1097/BCR.0000000000000538
   Spronk I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0197507
   Tan JL, 2019, BURNS TRAUMA, V7, DOI 10.1186/s41038-019-0151-6
   TANNER J C Jr, 1964, Plast Reconstr Surg, V34, P287
   Wu MF, 2023, PLAST RECONSTR SURG, V151, P779, DOI 10.1097/PRS.0000000000009997
   Wu MF, 2023, ADV WOUND CARE, V12, P483, DOI 10.1089/wound.2022.0074
   Wu MF, 2023, ADV WOUND CARE, V12, P301, DOI 10.1089/wound.2022.0005
   Ziegler B, 2020, ANN PLAS SURG, V85, P115, DOI 10.1097/SAP.0000000000002412
NR 31
TC 12
Z9 13
U1 1
U2 7
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAY
PY 2024
VL 50
IS 4
BP 1003
EP 1010
DI 10.1016/j.burns.2024.01.005
EA APR 2024
PG 8
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA QZ3A8
UT WOS:001224640400008
PM 38383170
DA 2026-07-24
ER
PT J
AU Muresan, M
   Suciu, H
   Marian, D
   Muresan, AV
   Gabor, RM
   Neagoe, RM
   Sala, D
   Denes, M
   Muresan, S
   Melano, MI
   Balmos, IA
AF Muresan, Mircea
   Suciu, Horatiu
   Marian, Dorin
   Muresan, Adrian Vasile
   Gabor, Rozalia Manuela
   Neagoe, Radu Mircea
   Sala, Daniela
   Denes, Marton
   Muresan, Simona
   Melano, Marina Isabella
   Balmos, Ioan Alexandru
TI A single-center prospective study on the efficiency of negative pressure
   wound therapy versus conventional wound therapy in the postoperative
   management of devitalized and infected wounds
SO ANNALI ITALIANI DI CHIRURGIA
LA English
DT Article
DE Negative pressure wound Therapy; Conventional wound therapy; Local
   healing; average cost
ID COST-EFFECTIVENESS
AB <bold>Introduction: </bold>In this study, we aim to present the benefits of using negative pressure wound therapy, particularly with respect to the speed up of recovery time of devitalized and infected post-operative wounds, cost-effectiveness of local healing, pain relief during treatment, and returning to work and resuming normal daily activities at an earlier time. <bold>Materials and methods: </bold>This was a prospective study performed in General Surgery Clinic, between 2016-2018. The study comprised 67 patients divided into two groups: A (29 patients who underwent negative pressure wound therapy) and B (38 patients who underwent conventional wound therapy). <bold>Results: </bold>The average age of patients included in group A was 64.2 +/- 12.3 years and in group B, 63.2 +/- 9.7 years (p=0.440). The wounds were located on the foot, thigh, abdomen, and other areas, and the average length of stay in hospital was 33 +/- 18 days for group A versus 17 +/- 14 days for group B (p=0.042) but with an average local healing time of 12 +/- 5 days in group A versus 44 +/- 17 days in group B (p<0.001). The average cost of hospitalization was higher in group A: 17,868 +/- 9,560 RON (3,834 +/- 2,051 euros) compared to group B: 6,025 +/- 4,137 RON (1,292 +/- 887 euros) (p=0.443) but the average cost of local healing was lower in group A: 5,437 +/- 2,238 RON (1,166 +/- 480 euro) compared to group B: 6,840 +/- 3,520 RON (1,467 +/- 755 euro) (p=0.005). <bold>Conclusions: </bold>The treatment of devitalized and infected post-operative wounds by using negative pressure wound therapy reduces local and complete healing time by approximately 30%, local healing costs by 26%, and allows better pain management during treatment with minimal complications.
C1 [Muresan, Mircea; Marian, Dorin; Neagoe, Radu Mircea; Sala, Daniela; Denes, Marton] Univ Med Pharm Sci & Technol Tirgu Mures, Surg Clin 2, Targu Mures, Romania.
   [Suciu, Horatiu] Univ Med Pharm Sci & Technol Tirgu Mures, Dept Surg, Targu Mures, Romania.
   [Muresan, Adrian Vasile] Univ Med Pharm Sci & Technol Tirgu Mures, Vasc Surg, Targu Mures, Romania.
   [Gabor, Rozalia Manuela] Univ Med Pharm Sci & Technol Tirgu Mures, Fac Econ Law & Adm Sci, Targu Mures, Romania.
   [Muresan, Simona; Melano, Marina Isabella] Univ Med Pharm Sci & Technol Tirgu Mures, Targu Mures, Romania.
   [Balmos, Ioan Alexandru] Univ Med Pharm Sci & Technol Tirgu Mures, Anat Dept, Targu Mures, Romania.
   [Muresan, Simona] Univ Med Pharm Sci & Technol Tirgu Mures, Physiol Dept, Gh Marinescu St 38, Targu Mures, Romania.
C3 George Emil Palade University of Medicine, Pharmacy, Science, &
   Technology of Targu Mures; George Emil Palade University of Medicine,
   Pharmacy, Science, & Technology of Targu Mures; George Emil Palade
   University of Medicine, Pharmacy, Science, & Technology of Targu Mures;
   George Emil Palade University of Medicine, Pharmacy, Science, &
   Technology of Targu Mures; George Emil Palade University of Medicine,
   Pharmacy, Science, & Technology of Targu Mures; George Emil Palade
   University of Medicine, Pharmacy, Science, & Technology of Targu Mures;
   George Emil Palade University of Medicine, Pharmacy, Science, &
   Technology of Targu Mures
RP Muresan, S (通讯作者)，Univ Med Pharm Sci & Technol Tirgu Mures, Physiol Dept, Gh Marinescu St 38, Targu Mures, Romania.
EM dr_mure-mir@yahoo.com
RI GABOR, Manuela Rozalia/AAK-9004-2020; Sala, Daniela
   Tatiana/IAM-2498-2023; Adrian, Muresan/HKM-3966-2023; Balmos, Ioan
   Alexanu/MBH-7042-2025; HORATIU, SUCIU/KFS-9863-2024; Muresan,
   Simona/KIG-8771-2024; Muresan, Mircea/LXV-0408-2024; Neagoe, Radu
   Mircea/AAE-6364-2022
OI GABOR, Manuela Rozalia/0000-0003-1025-869X; Balmos, Ioan
   Alexanu/0000-0002-7134-2660; Muresan, Mircea/0000-0002-5262-8524;
   Neagoe, Radu Mircea/0009-0006-0712-6070
CR [Anonymous], 2010, EQ EXC LIB NHS
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NR 27
TC 1
Z9 1
U1 0
U2 0
PU EDIZIONI LUIGI POZZI
PI ROME
PA VIA PANAMA 68, 00198 ROME, ITALY
SN 0003-469X
EI 2239-253X
J9 ANN ITAL CHIR
JI Ann. Ital. Chir.
PD JUL-AUG
PY 2023
VL 94
IS 4
BP 411
EP 418
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RD4D1
UT WOS:001225710100001
PM 37794810
DA 2026-07-24
ER
PT J
AU Jiang, XY
   Li, AX
   Hao, W
   Yang, C
   Wang, HY
   Deng, WQ
AF Jiang, Xiaoyan
   Li, Anxin
   Hao, Wei
   Yang, Cheng
   Wang, Hongyan
   Deng, Wuquan
TI Limb salvage and systemic management of gouty tophi: Case series
SO MEDICINE
LA English
DT Article
DE chronic refractory gout; diabetic foot ulcer; gouty tophi; limb salvage;
   negative pressure wound therapy; systemic therapy; wound healing
AB Introduction:Gout is a chronic disease characterized by deposition of monosodium urate crystals. Tophi develop in some individuals with untreated or uncontrolled gout, which leads to ulcerations, cosmetic problems, mechanical obstruction of joint movement, joint damage and musculoskeletal disability. Currently, the treatment of gouty tophi is controversial and challenging. Both surgical and internal medical treatments have limitations and require further exploration in clinical practice.Patient concerns:In Case 1, we treated a patient with severe infection of diabetic foot ulcers with concomitant multiple gouty tophi in the same limb. A systematic management strategy was formulated to close the wound and save the limb. The ulcers healed successfully after half a year. In Case 2, a giant gouty tophi located in the first metatarsophalangeal joint of the left foot was removed by surgical treatment and vancomycin-loaded bone cement implantation. In Case 3, we present a case of gouty tophi that was resolved by standardized systemic medical management.Diagnosis:Three patients were all diagnosed with gout accompanied by gouty deposition, although there were other different comorbidities.Interventions:In case 1, we used debridement to gradually remove gouty tophi. In case 2, the giant gouty tophi was removed by surgical operation. In case 3, the gouty tophi disappeared after standardized treatment with medicine, diet and lifestyle management.Outcomes:Three patients underwent different treatment therapies to remove gouty tophi based on their specific conditions.Lessons:We explored effective interventions for tophi in gout by surgical or other interventions in combination with pharmacotherapy.
C1 [Jiang, Xiaoyan; Li, Anxin; Hao, Wei; Yang, Cheng; Wang, Hongyan; Deng, Wuquan] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol & Metab, Chongqing 400014, Peoples R China.
C3 Chongqing University
RP Jiang, XY (通讯作者)，Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol & Metab, Chongqing 400014, Peoples R China.
EM 545816129@qq.com; 345110926@qq.com; 28179007@qq.com; happyyangc@163.com;
   1048989208@qq.com; wuquandeng@gmail.com
OI Jiang, Xiaoyan/0000-0002-1968-6810
FU Chongqing Medical Scientific Research Project (Chongqing Health
   Commission) [2020FYYX241]; Chongqing Medical Scientific Research Project
   (Science and Technology Bureau) [2020FYYX241]
FX This study was supported by the Chongqing Medical Scientific Research
   Project (Joint Project of Chongqing Health Commission and Science and
   Technology Bureau) (Grant No.2020FYYX241) awarded to Xiaoyan Jiang.
CR Carcione J, 2021, CURR RHEUMATOL REP, V23, DOI 10.1007/s11926-020-00969-6
   Dalbeth N, 2011, ARTHRIT CARE RES, V63, P1605, DOI 10.1002/acr.20570
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   Wu Z., 2022, MEDICINE, V101, pe28418
NR 14
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY 17
PY 2024
VL 103
IS 20
AR e38137
DI 10.1097/MD.0000000000038137
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RG7I6
UT WOS:001226575400068
PM 38758848
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhao, JC
   Shi, K
   Zhang, N
   Hong, L
   Yu, JA
AF Zhao, Jingchun
   Shi, Kai
   Zhang, Nan
   Hong, Lei
   Yu, Jiaao
TI Assessment between antiseptic and normal saline for negative pressure
   wound therapy with instillation and dwell time in diabetic foot
   infections
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Diabetic foot infection; PHMB; Negative pressure wound therapy;
   Instillation and dwell time
ID ANTIMICROBIAL SOLUTIONS; CLEANSING SOLUTION; BETAINE SOLUTION; BED
   PREPARATION; POLYHEXANIDE; BIOFILM; MANAGEMENT; IMPACT; RISK; GEL
AB Negative pressure wound therapy with instillation and dwell time (NPWTi-d) is increasingly used for a diverse range of wounds. Meanwhile, the topical wound irrigation solution consisting of polyhexamethylene biguanide and betaine (PHMB-B) has shown efficacy in managing wound infections. However, the effectiveness of this solution as a topical instillation solution for NPWTi-d in patients with diabetic foot infections (DFIs) has not been thoroughly studied. The objective of this retrospective study was to evaluate the impact of using PHMB-B as the instillation solution during NPWTi-d on reducing bioburden and improving clinical outcomes in patients with DFIs. Between January 2017 and December 2022, a series of patients with DFIs received treatment with NPWTi-d, using either PHMB-B or normal saline as the instillation solution. Data collected retrospectively included demographic information, baseline wound characteristics, and treatment outcomes. The study included 61 patients in the PHMB-B group and 73 patients in the normal saline group, all diagnosed with DFIs. In comparison to patients treated with normal saline, patients with PHMB-B exhibited no significant differences in terms of wound bed preparation time (P = 0.5034), length of hospital stay (P = 0.6783), NPWTi-d application times (P = 0.1458), duration of systematic antimicrobial administration (P = 0.3567), or overall cost of hospitalization (P = 0.6713). The findings of the study suggest that the use of either PHMB-B or normal saline as an instillation solution in NPWTi-d for DFIs shows promise and effectiveness, yet no clinical distinction was observed between the two solutions.
C1 [Zhao, Jingchun; Shi, Kai; Zhang, Nan; Hong, Lei; Yu, Jiaao] First Hosp Jilin Univ, Dept Burn Surg, 71 Xinmin St, Changchun 130021, Peoples R China.
C3 Jilin University
RP Yu, JA (通讯作者)，First Hosp Jilin Univ, Dept Burn Surg, 71 Xinmin St, Changchun 130021, Peoples R China.
EM yuja@jlu.edu.cn
RI Zhang, Nan/B-2532-2016
FU National Key Research and Development Program of China [2021YFF1201200];
   Health Science and Technology Ability Improvement Project of Jilin
   Province [2023LC004]
FX This work received grants from the National Key Research and Development
   Program of China (2021YFF1201200), the Health Science and Technology
   Ability Improvement Project of Jilin Province (2023LC004).
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NR 43
TC 10
Z9 11
U1 0
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 19
PY 2024
VL 14
IS 1
AR 11423
DI 10.1038/s41598-024-58900-3
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RK8D7
UT WOS:001227641500008
PM 38763922
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Su, SQ
   Xiong, DS
   Zeng, ZJ
   Ding, XM
   Kuang, JN
   Lin, YC
   Wu, YW
AF Su, Shunqing
   Xiong, Disheng
   Zeng, Zhijian
   Ding, Xiumei
   Kuang, Jinan
   Lin, Yuechun
   Wu, Yongwei
TI Repair of pressure ulcers in the elderly using autologous microskin
   implantation and negative pressure wound therapy: A retrospective study
SO TECHNOLOGY AND HEALTH CARE
LA English
DT Article
DE Elderly patients; pressure ulcers; skin grafts; vacuum sealing drainage;
   wound repair
ID MANAGEMENT; IMPACT
AB BACKGROUND: Pressure ulcers remain a worldwide problem.
   OBJECTIVE: To introduce an intermittent and feasible wound treatment method for the treatment of pressure ulcers in elderly patients.
   METHODS: This surgical procedure was performed on eight elderly patients suffering from pressure ulcers. Microskin measuring 0.1 x 0.1 centimeters was cut from a small amount of thin skin and then grafted onto the wound surface in conjunction with closed negative pressure therapy.
   RESULTS: Seven patients had their wounds closed after a single surgery, while one patient required two surgeries to close the wound.
   CONCLUSION: Autologous microskin implantation for the treatment of pressure ulcers in the elderly is an effective method to close the wound, which can prevent the elderly from living with wounds in their later years and is a viable treatment option.
C1 [Su, Shunqing; Xiong, Disheng; Ding, Xiumei; Kuang, Jinan; Lin, Yuechun; Wu, Yongwei] Dalang Hosp, Dept Wound Repair, Dongguan, Peoples R China.
   [Zeng, Zhijian] Dalang Hosp, Anorectal Dept, 85 Jinlangzhong Rd, Dongguan 523780, Guangdong, Peoples R China.
RP Zeng, ZJ (通讯作者)，Dalang Hosp, Anorectal Dept, 85 Jinlangzhong Rd, Dongguan 523780, Guangdong, Peoples R China.
EM zhijianzengche@126.com
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NR 20
TC 1
Z9 1
U1 1
U2 6
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 0928-7329
EI 1878-7401
J9 TECHNOL HEALTH CARE
JI Technol. Health Care
PY 2024
VL 32
IS 3
BP 1667
EP 1673
DI 10.3233/THC-230707
PG 7
WC Health Care Sciences & Services; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Engineering
GA RN5A3
UT WOS:001228342100034
PM 37694328
DA 2026-07-24
ER
PT J
AU Song, XL
   Zhao, S
   Wang, FY
   Liu, Y
   Wang, L
   Xu, YL
   Lv, L
   Duan, WX
   Zhang, HJ
   Bai, RZ
   Sun, HJ
   Shao, XZ
AF Song, Xiaoliang
   Zhao, Shuo
   Wang, Fengyu
   Liu, Yuan
   Wang, Li
   Xu, Yali
   Lv, Li
   Duan, Wenxu
   Zhang, Hongjuan
   Bai, Runze
   Sun, Hejun
   Shao, Xinzhong
TI Application of Human Acellular Dermal Matrix with Skin Graft for Lacunar
   Soft-Tissue Defect of Lateral Heel after Calcaneal Fracture
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE calcaneal fracture; cellular and/or tissue-based product; heel; human
   acellular dermal matrix; lacunar soft tissue defects; split-thickness
   skin graft; surgery; wound healing
ID PRESSURE WOUND THERAPY; COMPLICATIONS
AB OBJECTIVE: To investigate the clinical effect of human acellular dermal matrix (HADM) combined with split-thickness skin graft in repairing lacunar soft tissue defects of the lateral heel after calcaneal fracture. METHODS: From June 2018 to October 2020, providers repaired 11 cases of lacunar soft tissue defects at the lateral part of the heel using HADM combined with split-thickness skin graft. After thorough debridement, the HADM was trimmed and filled into the lacunar defect area. Once the wound was covered, a split-thickness skin graft and negative-pressure wound therapy were applied. Providers evaluated the appearance, scar, ductility of the skin graft site, appearance of the donor site, healing time, and any reoperation at follow-up. RESULTS: Of the 11 cases, 8 patients achieved successful wound healing by primary intention. Three patients showed partial necrosis in the edge of the skin graft, but the wound healed after standard wound care. Evaluation at 6 and 12 months after surgery showed that all patients had wound healing and mild local scarring; there was no obvious pigmentation or scar formation in the donor skin area. The average healing time was 37.5 days (range, 24-43 days). CONCLUSIONS: The HADM combined with split-thickness skin graft is a simple and effective reconstruction method for lacunar soft tissue defect of the lateral heel after calcaneal fracture. In this small sample, the combination demonstrated few infections, minor scar formation, few donor site complications, and relatively short hospital stays.
C1 [Song, Xiaoliang] Second Peoples Hosp Changzhi City, Orthoped Trauma Dept, Taiyuan, Shanxi, Peoples R China.
   [Zhao, Shuo] Hebei Childrens Hosp, Orthoped Dept, Shijiazhuang, Heibei, Peoples R China.
   [Wang, Fengyu; Liu, Yuan] Hebei Med Univ, Dept Hand Surg, Hosp 3, Shijiazhuang, Hebei, Peoples R China.
   [Liu, Yuan] Handan First Hosp, Dept Trauma & Orthoped, Handan, Peoples R China.
C3 Hebei Medical University
RP Song, XL (通讯作者)，Second Peoples Hosp Changzhi City, Orthoped Trauma Dept, Taiyuan, Shanxi, Peoples R China.
EM 591600366@qq.com; zzzozs@163.com; 15511615880@163.com; 85264233@qq.com;
   244514067@qq.com; 69508439@qq.com; budinglvli@163.com;
   duanwenxu86@163.com; zhj18533112606@qq.com; 451839993@qq.com;
   760721271@qq.com; a18533112809@163.com
RI Bai, Runze/IQS-7455-2023
CR Acevedo DC, 2015, ORTHOP CLIN N AM, V46, P377, DOI 10.1016/j.ocl.2015.02.006
   Belmonte BM, 2021, ANN PLAS SURG, V86, pS585, DOI 10.1097/SAP.0000000000002764
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   Seidel D, 2022, J FOOT ANKLE RES, V15, DOI 10.1186/s13047-022-00569-w
   Stanley BJ, 2017, VET CLIN N AM-SMALL, V47, P1203, DOI 10.1016/j.cvsm.2017.06.006
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   Wu CW, 2013, J PLAST RECONSTR AES, V66, P1376, DOI 10.1016/j.bjps.2013.05.018
   Yao CA, 2013, PRS-GLOB OPEN, V1, DOI 10.1097/GOX.0b013e3182aa8793
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NR 28
TC 1
Z9 2
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUN
PY 2024
VL 37
IS 6
BP 8
EP 8
DI 10.1097/ASW.0000000000000149
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA RN7M0
UT WOS:001228407000011
PM 38767429
OA hybrid
DA 2026-07-24
ER
PT J
AU Alt, V
   Rupp, M
   Kerschbaum, M
   Prantl, L
   Geis, S
AF Alt, Volker
   Rupp, Markus
   Kerschbaum, Maximilian
   Prantl, Lukas
   Geis, Sebastian
TI Treatment strategies for fracture-related infections with concurrent
   soft tissue damage
SO UNFALLCHIRURGIE
LA German
DT Review
DE Fracture-related infection; Surgical flaps; Ortho-plastic; Negative
   pressure wound therapy; Debridement
ID PRESSURE WOUND THERAPY; LOWER-EXTREMITY RECONSTRUCTION; ANTEROLATERAL
   THIGH; LOWER-LIMB; PERFORATOR FLAPS; DEFECTS; MANAGEMENT; COVERAGE;
   TRAUMA; SERIES
AB Fracture-related infections are the predominant complication following surgical fracture treatment. The distal lower leg, e.g., in pilon tibial fractures, is at a high risk of infection due to poor soft tissue coverage, particularly in cases of open fractures in this area. Fracture-related infections with significant soft tissue damage require special attention alongside treatment of the infection itself. In general, the principle is that healing of fracture-related infection is not possible without sufficient soft tissue coverage. Therefore, it is crucial to integrate both soft tissue damage and fracture-related infection into a comprehensive treatment plan from the beginning. An interdiscpilinary treatment approach between trauma and plastic surgery is often necessary and beneficial. In cases, where fracture fixation devices or bone is exposed, mid- or long-term use of vacuum-assisted wound therapy is not advisable due to a higher risk of reinfection. Hence, an interdisciplinary treatment strategy involving trauma and plastic surgery should prioritize early soft tissue closure, referred to as the "orthoplastic approach". If this cannot be done in the own hospital, early patient transfer is indicated to ensure optimal interdisciplinary therapy with early soft tissue closure and simultaneous trauma surgical treatment to control the infection and enable bone healing. Free fasciocutaneous or muscle flap techniques in combination with adequate trauma surgical and antibiotic therapy lead to good reliable results in these situations.
C1 [Alt, Volker; Rupp, Markus; Kerschbaum, Maximilian] Univ Klinikum Regensburg UKR, Klin & Poliklin Unfallchirurg, Franz Josef Str Allee 11, D-93053 Regensburg, Germany.
   [Prantl, Lukas; Geis, Sebastian] Univ Klinikum Regensburg UKR, Abt Plast Hand & Wiederherstellungschirurg, Regensburg, Germany.
C3 University of Regensburg; University of Regensburg
RP Alt, V (通讯作者)，Univ Klinikum Regensburg UKR, Klin & Poliklin Unfallchirurg, Franz Josef Str Allee 11, D-93053 Regensburg, Germany.
EM volker.alt@ukr.de
RI Rupp, Markus/ABH-5784-2022; Prantl, Lukas/AAM-1848-2021
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NR 40
TC 3
Z9 3
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2731-7021
EI 2731-703X
J9 UNFALLCHIRURGIE
JI Unfallchirurgie
PD FEB
PY 2024
VL 127
IS 2
SI SI
BP 103
EP 109
DI 10.1007/s00113-023-01403-z
EA JAN 2024
PG 7
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA D4N0H
UT WOS:001229039600001
PM 38167783
DA 2026-07-24
ER
PT J
AU Liu, YX
   Chen, N
AF Liu, Yuxin
   Chen, Na
TI Clinical evaluation of continuous irrigation with Bikerui combined with
   negative pressure closed drainage and platelet-rich plasma technique for
   treatment of stage III-IV pressure ulcer
SO POSTEPY DERMATOLOGII I ALERGOLOGII
LA English
DT Article
DE Bikerui disinfectant; negative pressure drainage; platelet-rich plasma;
   pressure ulcer; scar recovery
ID PREVENTION
AB Introduction: As a catastrophic complication of bedridden and elderly patients, pressure ulcer usually continuously affects patients' health and quality of life, so the daily care of wounds is attached great importance in clinic.
   Aim: This work investigated the effect of Bikerui disinfectant + vacuum sealing drainage (VSD) + platelet -rich plasma (PRP) therapy on patients with stage III similar to IV pressure sore.
   Material and methods: In this work, 110 patients with pressure ulcer (PU) treated in our hospital were enrolled and were randomly divided into an experimental group (Exp group) and a control group (Ctrl group) by a blind selection method, with 55 cases in each group. Patients in the Ctrl group received surgical debridement + VSD for treatment, while those in the Exp group were treated with Bikerui disinfectant + VSD + PRP. Inflammatory response (IR) score, PU healing (PUH) score, healing time, dressing change frequency (DCF), dressing interval time (DIT), and scar recovery (SR) score of patients in different groups were compared.
   Results: The results revealed that the positive rate of bacterial culture in wound secretions in the Exp group was greatly lower than that in the Ctrl group 1 or 2 weeks after treatment (p < 0.05). The IR score in the Exp group was much lower at week 1 and 2 after treatment (p < 0.05). The total effective rate (TER) in the Exp group was obviously higher than that in the Ctrl group (94.55% vs. 76.36%).
   Conclusions: The results suggested that Bikerui disinfectant + VSD + PRP therapy could effectively improve the inflammatory degree of PU patients, promote the wound repair and scar recovery of patients, and greatly improve the clinical efficacy of PU patients.
C1 [Liu, Yuxin] Xingtai Med Coll, Affiliated Hosp 2, Dept Tradit Chinese Med, Xingtai, Hebei, Peoples R China.
   [Chen, Na] Xingtai Med Coll, Affiliated Hosp 2, Dept Neurol, Xingtai, Hebei, Peoples R China.
C3 Xingtai Medical College; Xingtai Medical College
RP Liu, YX (通讯作者)，Xingtai Med Coll, Affiliated Hosp 2, Dept Tradit Chinese Med, Xingtai, Hebei, Peoples R China.
EM luzhaolan886459155@163.com
FU Xingtai Science and Technology Program, Clinical study on the treatment
   of stage III [2017ZC039]
FX The research was supported by the Xingtai Science and Technology
   Program, Clinical study on the treatment of stage III and IV pressure
   sores with continuous washing of Baikerui disinfectant combined with VSD
   and PRP technology (No. 2017ZC039) . Yuxin Liu and Na Chen contributed
   equally to this work as co-first author.
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NR 25
TC 2
Z9 2
U1 1
U2 7
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1642-395X
EI 2299-0046
J9 POSTEP DERM ALERGOL
JI Postep. Dermatol. Alergol.
PY 2024
VL 41
IS 2
BP 181
EP 188
DI 10.5114/ada.2024.138675
PG 8
WC Allergy; Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Dermatology
GA RT2G2
UT WOS:001229839700017
PM 38784931
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gonzalez, MR
   de Groot, TM
   Werenski, JO
   Fourman, MS
   Morse, AS
   Lozano-Calderon, SA
AF Gonzalez, Marcos R.
   de Groot, Tom M.
   Werenski, Joseph O.
   Fourman, Mitchell S.
   Morse, Ashlyn S.
   Lozano-Calderon, Santiago A.
TI Wound vacuum-assisted closure temporization after tumor resection of
   soft tissue sarcomas-A cost analysis in a propensity-score matched
   population
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE local recurrence; cost analysis; myxofibrosarcoma; soft tissue sarcoma;
   vacuum-assisted closure
ID RECURRENCE
AB BackgroundVacuum-assisted closure (VAC) temporization is a technique associated with high local control rates used in myxofibrosarcoma. We sought to compare the costs and postoperative outcomes of VAC temporization and single-stage (SS) excision/reconstruction.MethodsWe conducted a retrospective analysis of patients with myxofibrosarcoma surgically treated at our institution between 2000 and 2022. Variables of interest included total, direct, and indirect costs for initial episode of care, 90 days and 1 year after initial admission, and postoperative outcomes. Costs were compared between the VAC temporization and SS groups.ResultsAfter matching, 13 patients in the SS group and 23 in the VAC group were analyzed. We found no difference in median and mean total inpatient costs, between the VAC temporization and SS group. While total 90-day and 1-year costs were higher in the VAC group compared to the SS group, mean costs were similar. There were no differences in postoperative complications between groups. A subanalysis of the entire cohort (n = 139) revealed lower local recurrence and overall death rates in the VAC temporization group.ConclusionVAC temporization had similar inpatient costs and postoperative outcomes to SS excision/reconstruction. While median 90-day and 1-year costs were higher in the VAC group, mean costs did not differ.
C1 [Gonzalez, Marcos R.; de Groot, Tom M.; Werenski, Joseph O.; Morse, Ashlyn S.; Lozano-Calderon, Santiago A.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Orthopaed Surg, Div Orthopaed Oncol, Boston, MA USA.
   [Fourman, Mitchell S.] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Orthopaed Surg, New York, NY USA.
   [Lozano-Calderon, Santiago A.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Div Orthopaed Oncol, Boston, MA 02144 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School; Yeshiva University; Montefiore
   Medical Center; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Lozano-Calderon, SA (通讯作者)，Massachusetts Gen Hosp, Dept Orthopaed Surg, Div Orthopaed Oncol, Boston, MA 02144 USA.
EM slozanocalderon@mgh.harvard.edu
RI Fourman, Mitchell/GXF-4477-2022; Gonzalez, Marcos Roberto/IAP-3703-2023
OI Gonzalez, Marcos Roberto/0000-0002-3352-6362; Werenski,
   Joseph/0009-0003-9177-6874
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NR 22
TC 6
Z9 6
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD AUG
PY 2024
VL 130
IS 2
BP 301
EP 309
DI 10.1002/jso.27698
EA MAY 2024
PG 9
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA A4I1E
UT WOS:001231031100001
PM 38798273
DA 2026-07-24
ER
PT J
AU Felsenreich, DM
   Gachabayov, M
   Ritter, E
   Bergamaschi, R
AF Felsenreich, Daniel Moritz
   Gachabayov, Mahir
   Ritter, Edmond
   Bergamaschi, Roberto
TI En-bloc excision of sacral squamous cell carcinoma with immediate
   reconstruction
SO UPDATES IN SURGERY
LA English
DT Article; Early Access
DE Abdomino-perineal excision of rectum; Distal sacrectomy; Pilonidal cyst;
   Squamous cell carcinoma; Vertical rectus abdominis myocutaneous flap
ID PRESSURE ULCER; WOUNDS
AB Sacral squamous cell carcinoma is an uncommon condition that may arise in scars following burns or in chronic wounds, such as an untreated pilonidal cyst. The aim of the present technical note is to describe a surgical technique aimed at minimizing local recurrence rates by en-bloc resection as well as providing immediate plastic reconstruction: 1. right-sided extended vertical rectus abdominis myo-cutaneous (VRAM) flap; 2. abdomino-perineal excision of the rectum with end colostomy; 3. en-bloc excision of the mass inclusive of gluteus maximus muscles and distal sacrectomy; 4. sacrectomy defect covered with VRAM flap; 5. bilateral gluteal defects covered with single-layer dermal substitute of bovine collagen and elastin hydrolysate followed by immediate split-thickness skin grafting from bilateral thigh donor sites, and negative pressure wound therapy dressings. This approach resulted in a favorable outcome at 2-year follow-up in a male patient presenting with a large locally advanced sacral squamous cell carcinoma involving the external anal sphincter muscle.
C1 [Felsenreich, Daniel Moritz; Gachabayov, Mahir; Bergamaschi, Roberto] New York Med Coll, Westchester Med Ctr, Dept Surg, Sect Colorectal Surg, Valhalla, NY 10595 USA.
   [Ritter, Edmond] New York Med Coll, Westchester Med Ctr, Dept Surg, Sect Plast Surg, Valhalla, NY USA.
   [Bergamaschi, Roberto] New York City Hlth Hosp, Jacobi Med Ctr, Dept Surg, Suite 610, 1400 Pelham Pkwy South, New York, NY 10461 USA.
C3 Westchester Medical Center; New York Medical College; New York Medical
   College; Westchester Medical Center; Jacobi Medical Center
RP Bergamaschi, R (通讯作者)，New York Med Coll, Westchester Med Ctr, Dept Surg, Sect Colorectal Surg, Valhalla, NY 10595 USA.; Bergamaschi, R (通讯作者)，New York City Hlth Hosp, Jacobi Med Ctr, Dept Surg, Suite 610, 1400 Pelham Pkwy South, New York, NY 10461 USA.
EM rcmbergamaschi@gmail.com
RI Bergamaschi, Roberto/I-1984-2015; Gachabayov, Mahir/M-2659-2015
OI Bergamaschi, Roberto/0000-0001-9993-0563; 
CR Choa R, 2015, BMJ-BRIT MED J, V351, DOI 10.1136/bmj.h3997
   Chou CY, 2015, OSTOMY WOUND MANAG, V61, P48
   Cocchetto Vanessa, 2013, Dermatol Online J, V19, P7
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   Kerr-Valentic MA, 2009, PLAST RECONSTR SURG, V123, P184, DOI 10.1097/PRS.0b013e3181904d86
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   NOVICK M, 1977, J TRAUMA, V17, P809, DOI 10.1097/00005373-197710000-00010
   Oltra AM, 2020, INT J SURG CASE REP, V70, P172, DOI 10.1016/j.ijscr.2020.04.043
   Pekarek Brian, 2011, J Am Col Certif Wound Spec, V3, P60, DOI 10.1016/j.jcws.2012.04.001
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   Simman R, 2021, WOUNDS, V33, pE53
   Trent Jennifer T, 2003, Adv Skin Wound Care, V16, P31, DOI 10.1097/00129334-200301000-00014
NR 14
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD 2024 APR 30
PY 2024
DI 10.1007/s13304-024-01861-z
EA APR 2024
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RX8I3
UT WOS:001231044300002
PM 38691330
DA 2026-07-24
ER
PT J
AU Kominiarek, MA
   Espinal, M
   Cassimatis, IR
   Peace, JM
   Premkumar, A
   Toledo, P
   Shramuk, M
   Wafford, EQ
AF Kominiarek, Michelle A.
   Espinal, Mariana
   Cassimatis, Irina R.
   Peace, Jack M.
   Premkumar, Ashish
   Toledo, Paloma
   Shramuk, Maxwell
   Wafford, Eileen Q.
TI Peripartum interventions for people with class III obesity: a systematic
   review and meta-analysis
SO AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
LA English
DT Review
DE Key words: anticoagulation; body mass index; cesarean delivery
   techniques; induction of labor; prophylactic antibiotics; wound
   complications
ID PRESSURE WOUND THERAPY; SURGICAL-SITE INFECTION; CESAREAN DELIVERY;
   WOMEN; COMPLICATIONS; SECTION; LABOR; RISK; MANAGEMENT; PREGNANCY
AB OBJECTIVE: This study aimed to identify evidence-based peripartum interventions for people with a body mass index >= 40 kg/m 2 . DATA SOURCES: PubMed, MEDLINE, EMBASE, Cochrane, CINAHL, and ClinicalTrials.gov were searched from inception to 2022 without date, publication type, or language restrictions. STUDY ELIGIBILITY CRITERIA: Cohort and randomized controlled trials that implemented an intervention and evaluated peripartum outcomes of people with a body mass index >= 40 kg/m 2 were included. The primary outcome depended on the intervention but was commonly related to wound morbidity after cesarean delivery (ie, infection, separation, hematoma). METHODS: Meta-analysis was completed for interventions with at least 2 studies. Pooled risk ratios with 95% con fidence intervals and heterogeneity (I 2 statistics) were reported. RESULTS: Of 20,301 studies screened, 30 studies (17 cohort and 13 randomized controlled trials) encompassing 10 types of interventions were included. The interventions included delivery planning (induction of labor, planned cesarean delivery), antibiotics during labor induction or for surgical prophylaxis, 6 types of cesarean delivery techniques, and anticoagulation dosing after a cesarean delivery. Planned cesarean delivery compared with planned vaginal delivery did not improve outcomes according to 3 cohort studies. One cohort study compared 3 g with 2 g of cephazolin prophylaxis for cesarean delivery and found no differences in surgical site infections. According to 3 cohort studies and 2 randomized controlled trials, there was no improvement in outcomes with a non -low transverse skin incision. Ten studies (4 cohort and 6 randomized controlled trials) met the inclusion criteria for the meta-analysis. Two randomized controlled trials compared subcuticular closure with suture vs staples after cesarean delivery and found no differences in wound morbidity within 6 weeks of cesarean delivery (n=422; risk ratio, 1.09; 95% con fidence interval, 0.75 -1.59; I-2 =9%). Prophylactic negative-pressure wound therapy was compared with standard dressing in 4 cohort and 4 randomized controlled trials, which found no differences in wound morbidity (cohort n=2200; risk ratio, 1.19; 95% con fidence interval, 0.88 -1.63;I-2 =66.1%) or surgical site infections (randomized controlled trial n=1262; risk ratio, 0.90; 95% con fidence interval, 0.63 -1.29;I-2 =0). CONCLUSION: Few studies address interventions in people with a body mass index >= 40 kg/m(2) , and most studies did not demonstrate a bene fit. Either staples or suture are recommended for subcuticular closure, but available data do not support prophylactic negative-pressure wound therapy after cesarean delivery for people with a body mass index >= 40 kg/m(2) .
C1 [Kominiarek, Michelle A.; Espinal, Mariana] Northwestern Univ, Dept Obstet & Gynecol, Div Maternal Fetal Med, Feinberg Sch Med, Chicago, IL 60208 USA.
   [Cassimatis, Irina R.] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Div Maternal Fetal Med, Portland, OR USA.
   [Peace, Jack M.] Temple Univ, Dept Anesthesiol, Lewis Katz Sch Med, Philadelphia, PA USA.
   [Premkumar, Ashish] Univ Chicago, Dept Obstet & Gynecol, Div Maternal Fetal Med, Chicago, IL USA.
   [Toledo, Paloma] Univ Miami, Dept Anesthesiol, Miami, FL USA.
   [Shramuk, Maxwell] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL USA.
   [Wafford, Eileen Q.] Northwestern Univ, Galter Hlth Sci Lib & Learning Ctr, Feinberg Sch Med, Chicago, IL USA.
C3 Northwestern University; Feinberg School of Medicine; Oregon Health &
   Science University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Temple University; University of Chicago; University of Miami;
   Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine
RP Kominiarek, MA (通讯作者)，Northwestern Univ, Dept Obstet & Gynecol, Div Maternal Fetal Med, Feinberg Sch Med, Chicago, IL 60208 USA.
EM mkominia@nm.org
OI Cassimatis, Irina/0000-0002-0385-9502; Wafford, Q.
   Eileen/0000-0001-5228-8219; Premkumar, Ashish/0000-0001-6952-9955;
   kominiarek, michelle/0000-0003-0064-2399; Shramuk,
   Max/0009-0000-7453-2948
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NR 55
TC 5
Z9 6
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2589-9333
J9 AM J OBST GYNEC MFM
JI Amer. J. Obstet. Gynecol. MFM
PD MAY
PY 2024
VL 6
IS 5
AR 101354
DI 10.1016/j.ajogmf.2024.101354
EA APR 2024
PG 16
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA SM2D3
UT WOS:001234795200001
PM 38494155
DA 2026-07-24
ER
PT J
AU Fujisawa, K
   Miyamoto, S
   Saito, Y
   Okazaki, M
AF Fujisawa, Kou
   Miyamoto, Shimpei
   Saito, Yuki
   Okazaki, Mutsumi
TI Negative Pressure Wound Therapy with Instillation and Dwell Time for
   Pharyngocutaneous Fistula
SO LARYNGOSCOPE
LA English
DT Article
DE head and neck reconstruction; negative pressure wound therapy with
   instillation and dwell time; pharyngocutaneous fistula
AB Pharyngocutaneous fistula is a critical complication of head and neck cancer reconstruction and it is often difficult to manage. We herein report two cases of pharyngocutaneous fistulas that developed after oropharyngeal reconstruction and were successfully treated with negative pressure wound therapy with instillation and dwell time (NPWTi-d), an advanced form of traditional NPWT. NPWTi-d may be a useful nonsurgical treatment for pharyngocutaneous fistula. Laryngoscope, 2024
   Pharyngocutaneous fistula is a critical complication of head and neck cancer reconstruction and it is often difficult to manage. We herein report two cases of pharyngocutaneous fistulas that developed after oropharyngeal reconstruction and were successfully treated with negative pressure wound therapy with instillation and dwell time (NPWTi-d), an advanced form of traditional NPWT. NPWTi-d may be a useful nonsurgical treatment for pharyngocutaneous fistula. image
C1 [Fujisawa, Kou; Miyamoto, Shimpei; Okazaki, Mutsumi] Univ Tokyo, Dept Plast & Reconstruct Surg, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138655, Japan.
   [Saito, Yuki] Univ Tokyo, Dept Otolaryngol & Head & Neck Surg, Tokyo, Japan.
C3 University of Tokyo; University of Tokyo
RP Fujisawa, K (通讯作者)，Univ Tokyo, Dept Plast & Reconstruct Surg, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138655, Japan.
EM kofujisawa@gmail.com
RI ; Okazaki, Mutsumi/ISU-1959-2023; Fujisawa, Kou/AIB-5993-2022
OI Fujisawa, Kou/0000-0003-3601-7739; 
CR Asher SA, 2014, JAMA FACIAL PLAST SU, V16, P120, DOI 10.1001/jamafacial.2013.2163
   De Pellegrin L, 2023, INT WOUND J, V20, P2402, DOI 10.1111/iwj.14072
   Liebman RM, 2023, SEMIN PLAST SURG, V37, P9, DOI 10.1055/s-0042-1759562
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   Steinbichler TB, 2021, HEAD NECK-J SCI SPEC, V43, P2377, DOI 10.1002/hed.26684
NR 5
TC 3
Z9 4
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD NOV
PY 2024
VL 134
IS 11
BP 4573
EP 4576
DI 10.1002/lary.31549
EA JUN 2024
PG 4
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA J8A7V
UT WOS:001236216500001
PM 38822695
DA 2026-07-24
ER
PT J
AU Kim, PJ
   Fernandez, L
   Obst, MA
   Chaffin, A
   Faust, E
   Lantis, J
   Couch, K
   Desvigne, M
   Suski, M
   Kundu, N
   Mathews, M
   Simman, R
   Murphy, C
   Nierenberg, NE
   Téot, L
AF Kim, Paul J.
   Fernandez, Luis
   Obst, Mary Ann
   Chaffin, Abigail
   Faust, Elizabeth
   Lantis, John
   Couch, Kara
   Desvigne, Michael
   Suski, Mark
   Kundu, Neilendu
   Mathews, Marc
   Simman, Richard
   Murphy, Christine
   Nierenberg, Natalie E.
   Teot, Luc
TI Multidisciplinary Expert Consensus Statements and Recommendations for
   Use of Hypochlorous Acid as a Solution for Negative Pressure Wound
   Therapy With Instillation
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE antiseptic; bacteria; hypochlorous acid; negative pressure wound therapy
   with instillation and dwell time; NPWTi-d; wound
ID VACUUM-ASSISTED CLOSURE; MECHANISMS; STANDARD; OUTCOMES; CARE
AB Background. HOCl (eg, pHAp) preserved solutions have antimicrobial properties and are considered safe and effective for wound management. NPWTi-d (or NPWTi) is an established adjunctive wound modality for a variety of wound etiologies in various anatomic locations in which an instillate solution dwells on the surface of the wound to assist in wound bed preparation. A variety of solutions have been used, including 0.9% normal saline wound cleansers and antiseptics. pHAp is growing in popularity as the solution of choice for NPWTi-d. Objective. To evaluate consensus statements on the use of NPWTi-d with pHAp. Methods. A 15 -member multidisciplinary panel of expert clinicians in the United States, Canada, and France convened in person in April 2023 in Washington, D.C. and/or corresponded later to discuss 10 statements on the use of pHAp with NPWTi-d. The panelists then replied "agree" or "disagree" to each statement and had the option to provide comments. Results. Ten consensus statements are presented, along with the proportion of agreement or disagreement and summary comments. Although agreement with the statements on NPWTi-d with pHAp varied, the statements appear to reflect individual preferences for use rather than concerns about safety or efficacy. Conclusion. The consensus indicates that NPWTi-d with pHAp can have a beneficial effect in wound care.
C1 [Kim, Paul J.] Univ Texas Southwestern, Dept Plast Surg, Dept Orthoped Surg, Dallas, TX 75390 USA.
   [Fernandez, Luis] Univ Texas Hlth Sci Ctr Tyler, Dept Surg, Div Trauma Surg Surg Crit Care, Trauma Surg, Tyler, TX USA.
   [Obst, Mary Ann] Reg Hosp, Dept Surg, St Paul, MN USA.
   [Chaffin, Abigail] Tulane Univ, Sch Med, Dept Surg, Div Plast & Reconstruct Surg, New Orleans, LA USA.
   [Faust, Elizabeth] Reading Hosp, Dept Plast Surg Wound Care, W Reading, PA USA.
   [Lantis, John] Icahn Sch Med Mt Sinai West, New York, NY USA.
   [Couch, Kara] George Washington Univ Hosp, Washington, DC USA.
   [Desvigne, Michael] Abrazo Arrowhead Hosp, Glendale, AZ USA.
   [Suski, Mark] Los Robles Reg Med Ctr, Ctr Adv Wound Healing, Thousand Oaks, CA USA.
   [Kundu, Neilendu] Mercy Hlth, Dept Plast Reconstruct Surg, Cincinnati, OH USA.
   [Mathews, Marc] Univ Arizona, Dept Surg, Tucson, AZ USA.
   [Simman, Richard] Univ Toledo, Coll Med & Life Sci, Div Plast Surg, Toledo, OH USA.
   [Murphy, Christine] Ottawa Hosp, Limb Preservat Ctr, Ottawa, ON, Canada.
   [Nierenberg, Natalie E.] Tufts Univ, Sch Med, Dept Geog Med & Infect Dis, Boston, MA USA.
   [Teot, Luc] Montpellier Univ Hosp, Dept Plast Surg, Montpellier, France.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas-Health Sciences
   Center at Tyler (UTHSCT); Tulane University; Mount Sinai West; Icahn
   School of Medicine at Mount Sinai; George Washington University;
   University of Arizona; University System of Ohio; University of Toledo;
   University of Ottawa; Ottawa Hospital Research Institute; Tufts
   University; Universite de Montpellier; CHU de Montpellier
RP Kim, PJ (通讯作者)，Univ Texas Southwestern, Dept Plast Surg, Dept Orthoped Surg, Dallas, TX 75390 USA.
EM Paul.Kim@UTSouthwestern.edu
RI Oceja, Luis/B-5599-2011
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   Wang L, 2007, J Burns Wounds, V6, pe5
NR 45
TC 1
Z9 2
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2024
VL 36
IS 4
BP 108
EP 114
DI 10.25270/wnds/23143
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SU7T7
UT WOS:001237033200003
PM 38743855
DA 2026-07-24
ER
PT J
AU Soto, AL
   Olszewski, TM
   Barr, J
AF Soto, Alexandria L.
   Olszewski, Todd M.
   Barr, Justin
TI Medicine's Glass Slipper: The PAVAEX Boot and 20th Century Negative
   Pressure Therapy
SO AMERICAN SURGEON
LA English
DT Article
DE peripheral arterial disease; negative pressure therapy; wound healing;
   vascular surgery; PAVAEX Boot; Louis Herrmann; history; history of
   medicine
ID EXTREMITIES
AB Before the 20th century, peripheral artery disease (PAD) manifested as extreme pain, chronic wounds, and, eventually, gangrene requiring amputation. Despite this, it was rarely diagnosed. However, at the turn of the century, Western medicine shifted focus from infectious to chronic illnesses, and with this change, physicians' engagement with PAD transformed. Aiming to mitigate long-term injury, physicians now worked to identify and treat vessel disease to restore meaningful blood circulation. This article explores the development and deployment of a new device resulting from this refocus, the PAssive VAscular EXerciser (PAVAEX) Boot, and its role as a creative response to a previously intractable clinical problem. The PAVAEX Boot, designed in 1933 by vascular surgeons Louis G. Herrmann and Mont R. Reid, was one of the few interventions for PAD at the time. Based on the observation that continuous negative pressure results in vasoconstriction, while short bursts transiently increase blood flow, the PAVAEX Boot utilized intermittent negative pressure to enhance peripheral vascular perfusion. Well-marketed and praised throughout the 1930s, it vanished from public writing and academic literature just 20 years later. However, negative pressure wound therapy resurged in the late 20th century, and though its inventors failed to recognize the precedent of the PAVAEX Boot, many of these devices and therapies are rooted in identical theories. We examine why the PAVAEX Boot faded from use and argue that the device remains a crucial advancement in negative pressure therapy.
C1 [Soto, Alexandria L.] Duke Univ, Sch Med, 40 Duke Med Circle,124 Davison Bldg, Durham, NC 27710 USA.
   [Soto, Alexandria L.] Harvard Univ, Dept Hist Sci, Cambridge, MA USA.
   [Olszewski, Todd M.] Providence Coll, Dept Hlth Sci, Providence, RI USA.
   [Barr, Justin] Univ Toronto, Dept Surg, Toronto, ON, Canada.
C3 Duke University; Harvard University; Providence College; University of
   Toronto
RP Soto, AL (通讯作者)，Duke Univ, Sch Med, 40 Duke Med Circle,124 Davison Bldg, Durham, NC 27710 USA.
EM Alexandria.soto@duke.edu
RI ; Soto, Alexandria/IVV-3550-2023; Olszewski, Todd/AAC-6514-2021
OI Barr, Justin/0000-0003-0143-0603; Soto, Alexandria/0000-0003-1742-5251;
   Olszewski, Todd/0009-0002-6886-3825
CR Allen AW, 1930, ANN SURG, V92, P931
   [Anonymous], 1965, ESC Q MED PROFESSION, V23, P44
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   Circulator Boot-Product Overview, 2023, AM MED EQ
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NR 25
TC 1
Z9 1
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD NOV
PY 2024
VL 90
IS 11
BP 3164
EP 3169
DI 10.1177/00031348241259041
EA JUN 2024
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J1B9N
UT WOS:001238161400001
PM 38830241
DA 2026-07-24
ER
PT J
AU Vaddavalli, V
   Girdhani, B
   Savlania, A
   Behera, A
   Rastogi, A
   Kaman, L
   Abuji, K
AF Vaddavalli, Vv
   Girdhani, B.
   Savlania, A.
   Behera, A.
   Rastogi, A.
   Kaman, L.
   Abuji, K.
TI Effectiveness of incisional negative pressurewound therapy after major
   lower extremityamputation: a randomised controlled trial
SO ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
LA English
DT Article
DE Amputation; Surgical site infection; PAD; iNPWT; Stump dehiscence; RCT
ID SURGICAL SITE INFECTION; WOUND THERAPY; COMPLICATIONS
AB Introduction The aim was to study the effect of incisional negative pressure wound therapy (iNPWT) in wound healing compared with standard sterilegauze dressings after major lower extremity amputation in patients with peripheral arterial disease (PAD). Methods This prospective, randomised controlled trial included 50 patients undergoing major lower extremity amputations for PAD. Patients wererandomised into iNPWT and standard dressing groups. The patency of blood vessels at the level of the stump was ensured with or withoutrevascularisation. The primary outcome was wound-related complications such as surgical site infection (SSI), wound dehiscence, seroma/haematoma formation or the need for revision amputation. The secondary outcome was the time taken for the eligibility of prosthesis placement. Results It was found that only 12% of the patients in the iNPWT group had SSI compared with 36% in the standard dressing group (p=0.047). Rates ofwound dehiscence, seroma/haematoma formation and revision amputation were decreased in the iNPWT group but this was not statistically significant(p> 0.05). There was a significant reduction in the time taken for eligibility of prosthesis placement in the iNPWT group (5.12 +/- 1.53 vs 6.8 +/- 1.95 weeks,p=0.002). Conclusions iNPWT is effective in reducing the incidence of SSI and the time taken for rehabilitation in patients undergoing major lower limb amputationdue to PAD
C1 [Vaddavalli, Vv; Girdhani, B.; Savlania, A.; Behera, A.; Rastogi, A.; Kaman, L.; Abuji, K.] Post Grad Inst Med Educ & Res, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Savlania, A (通讯作者)，Post Grad Inst Med Educ & Res, Chandigarh, India.
EM drajaysavlania@gmail.com
RI Rastogi, Ashu/AAW-1759-2020; kaman, lileswar/AAO-7634-2021
FU Department of General Surgery, Post Graduate Institute of Medical
   Education and Research, Chandigarh, India
FX We received a research grant from the Department of General Surgery,
   Post Graduate Institute of Medical Education and Research, Chandigarh,
   India.
CR Advanced Amputee Solutions, Amputee Statistics
   BERRIDGE DC, 1989, J HOSP INFECT, V13, P167, DOI 10.1016/0195-6701(89)90023-6
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NR 28
TC 4
Z9 4
U1 0
U2 1
PU ROYAL COLL SURGEONS ENGLAND
PI LONDON
PA 35-43 LINCOLN'S INN FIELDS, LONDON WC2A 3PN, ENGLAND
SN 0035-8843
EI 1478-7083
J9 ANN ROY COLL SURG
JI Ann. R. Coll. Surg. Engl.
PD MAY
PY 2024
VL 106
IS 5
DI 10.1308/rcsann.2023.0011
PG 84
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TC0W2
UT WOS:001238951600006
PM 37435705
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Soliman, F
   Zwiep, T
AF Soliman, F.
   Zwiep, T.
TI Intraluminal negative pressure wound therapy and rectal anastomotic leak
   management: regular vac sponge and a nasogastric tube
SO ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
LA English
DT Article
C1 [Soliman, F.; Zwiep, T.] London Hlth Sci Ctr, Dept Colorectal Surg, London, ON, Canada.
C3 London Health Sciences Centre
RP Soliman, F (通讯作者)，London Hlth Sci Ctr, Dept Colorectal Surg, London, ON, Canada.
EM solimanf@doctors.org.uk
FU Department of General Surgery, Post Graduate Institute of Medical
   Education and Research, Chandigarh, India
FX We received a research grant from the Department of General Surgery,
   Post Graduate Institute of Medical Education and Research, Chandigarh,
   India.
CR National Institute for Health and Care Excellence (NICE), NICE Guideline MTG63
NR 1
TC 0
Z9 0
U1 1
U2 1
PU ROYAL COLL SURGEONS ENGLAND
PI LONDON
PA 35-43 LINCOLN'S INN FIELDS, LONDON WC2A 3PN, ENGLAND
SN 0035-8843
EI 1478-7083
J9 ANN ROY COLL SURG
JI Ann. R. Coll. Surg. Engl.
PD MAY
PY 2024
VL 106
IS 5
PG 84
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TC0W2
UT WOS:001238951600012
DA 2026-07-24
ER
PT J
AU Fiocco, A
   Dini, M
   Lorenzoni, G
   Gregori, D
   Colli, A
   Besola, L
AF Fiocco, A.
   Dini, M.
   Lorenzoni, G.
   Gregori, D.
   Colli, A.
   Besola, L.
TI The prophylactic use of negative-pressure wound therapy after cardiac
   surgery: a meta-analysis
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE Negative-pressure wound; therapy; Surgical site infections; Cardiac
   surgery; Advanced medication
ID SURGICAL SITE COMPLICATIONS; KNEE ARTHROPLASTY; RISK-FACTORS;
   INFECTIONS; MANAGEMENT; CARE
AB Surgical site infections (SSIs) pose a frequent complication in cardiac surgery patients and lead to increased patient discomfort and extended hospitalization. This meta-analysis aimed to evaluate the protective role of single-use negative-pressure wound therapy (sNPWT) devices on closed surgical wounds after cardiac surgery, and explored their potential preventive application across all cardiac surgery patients. A comprehensive literature search was conducted on ScienceDirect, focusing on studies related to "negative pressure wound therapy" or "PICO negative pressure wound therapy" combined with "cardiac surgery" or "sternotomy," published between 2000 and 2022. Inclusion criteria encompassed case-control studies comparing sNPWT with traditional dressings on closed cardiac surgical incisions in adult patients undergoing median sternotomy without immediate postoperative infective complications, with available details on SSIs. A retrospective analysis of cases treated with sNPWT in our centre was also performed. The metaanalysis revealed a protective role of sNPWT, indicating a 44% risk reduction in overall SSIs (odds ratio 0.56) and a 40% risk reduction in deep wound infections (odds ratio 0.60). Superficial wound infections, however, showed non-significant protective effects. A singlecentre study aligned with the meta-analysis findings, confirming the efficacy of sNPWT and was included in the meta-analysis. In conclusion, the meta-analysis and the single-centre study collectively support the protective role of negative pressure wound therapy against overall and deep SSIs, suggesting its potential prophylactic use on all cardiac surgery populations. (c) 2024 Published by Elsevier Ltd on behalf of The Healthcare Infection Society.
C1 [Fiocco, A.; Dini, M.; Colli, A.; Besola, L.] Univ Pisa, Dept Surg Med & Mol Pathol & Crit Care Med, Cardiac Surg Unit, Pisa, Italy.
   [Lorenzoni, G.; Gregori, D.] Univ Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Unit Biostat Epidemiol & Publ Hlth, Padua, Italy.
   [Colli, A.] Univ Pisa, Dept Surg Med & Mol Pathol & Crit Care Med, Via Paradisa 2, I-56124 Pisa, Italy.
C3 University of Pisa; University of Padua; University of Pisa
RP Colli, A (通讯作者)，Univ Pisa, Dept Surg Med & Mol Pathol & Crit Care Med, Via Paradisa 2, I-56124 Pisa, Italy.
EM colli.andrea.bcn@gmail.com
RI Lorenzoni, Giulia/AAB-9946-2019; Besola, Laura/ABC-1464-2021; fiocco,
   alessandro/AAC-6017-2022; Colli, Andrea/KVA-8732-2024; Gregori,
   Dario/F-9974-2012
OI Lorenzoni, Giulia/0000-0003-1771-4686; Besola,
   Laura/0000-0003-4460-8133; Dini, Martina/0009-0000-6249-8877; 
CR Agarwal A, 2019, PLAST RECONSTR SURG, V143, p21S, DOI 10.1097/PRS.0000000000005308
   [Anonymous], 2023, R Foundation for Statistical Computing
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   Bottigliengo D, 2021, BMC MED RES METHODOL, V21, DOI 10.1186/s12874-021-01454-z
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   Dohle K, 2020, Thorac Cardiovasc Surg, V68, pS1
   Doman DM, 2021, J ARTHROPLASTY, V36, P3437, DOI 10.1016/j.arth.2021.05.030
   Feinstein GI, 2019, PLAST RECONSTR SURG, V143, p27S, DOI 10.1097/PRS.0000000000005309
   Garrido-Martin P, 2022, British Journal of Heart Diseases, V4, P170
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   Grauhan O, 2013, J THORAC CARDIOV SUR, V145, P1387, DOI 10.1016/j.jtcvs.2012.09.040
   Groenen H, 2023, ECLINICALMEDICINE, V62, DOI 10.1016/j.eclinm.2023.102105
   Gudbjartsson T, 2016, SCAND CARDIOVASC J, V50, P341, DOI 10.1080/14017431.2016.1180427
   Higgins J.P. T., 2011, Cochrane Handb Syst Rev Interv, DOI DOI 10.1002/9781119536604.CH8
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   Myllykangas HM, 2022, THORAC CARDIOV SURG, V70, P65, DOI 10.1055/s-0041-1731767
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   Ousey KJ, 2013, SPINE J, V13, P1393, DOI 10.1016/j.spinee.2013.06.040
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   XLSTAT Addinsoft, 2021, A complete statistical add-in for Microsoft Excel
NR 39
TC 4
Z9 5
U1 0
U2 1
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD JUN
PY 2024
VL 148
BP 95
EP 104
DI 10.1016/j.jhin.2024.04.003
EA MAY 2024
PG 10
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA TF4V4
UT WOS:001239842800001
PM 38677481
DA 2026-07-24
ER
PT J
AU VanDolah, HB
   Li, KR
   Kim, KG
   Berger, LE
   Tefera, EA
   Acuna, KA
   Attinger, CE
   Fan, KL
   Evans, KK
AF VanDolah, Hunter B.
   Li, Karen R.
   Kim, Kevin G.
   Berger, Lauren E.
   Tefera, Eshetu A.
   Acuna, Kelly A.
   Attinger, Christopher E.
   Fan, Kenneth L.
   Evans, Karen K.
TI Positive Bacterial Cultures on Spinal Wound Closure Do Not Predict
   Postoperative Outcomes
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE wound infection; surgical wound infection; postoperative care; soft
   tissue infections; surgical wound dehiscence; surgical flaps
ID RISK-FACTORS; MANAGEMENT; INFECTIONS; RECONSTRUCTION; SURGERY; FUSION;
   COST
AB BackgroundComplex surgical back wounds represent significant morbidity in patients who have undergone spinal procedures requiring closure or revision by plastic surgeons. This study aimed to assess the utility of bacterial wound culture data for predicting surgical outcomes of wound management.MethodsThis study is a single-institution retrospective review of consecutive patients who required plastic surgery intervention for wound infection following spinal procedures between the years 2010 and 2021 (n = 70). Statistical analysis was performed for demographics, comorbidities, perioperative laboratory studies, and treatment methods. The primary outcomes of interest were rate of postoperative complications after soft tissue reconstruction and reconstructive failure. The secondary outcome of interest was time to healing in number of days.ResultsThe overall complication rate after wound closure was 31.4%, with wound infection in 12.9%, seroma in 10%, dehiscence in 12.9%, and hematoma in 1.4%. Increasing number of debridements before wound closure increased the likelihood of a surgical complication of any kind (odds ratio [OR], 1.772; 95% confidence interval [CI], 1.045-3.002). Positive wound cultures before reconstruction were associated with development of seroma only (OR, 0.265; 95% CI, 0.078-0.893). Use of incisional vacuum-assisted closure devices significantly decreased the odds of postoperative wound dehiscence (OR, 0.179; 95% CI, 0.034-0.904) and increased odds of healing (hazard ratio, 3.638; 95% CI, 1.547-8.613).ConclusionsPositive wound cultures were not significantly associated with negative outcomes after complex closure or reconstruction of infected spinal surgical wounds. This finding emphasizes the importance of clinical judgment with a multidisciplinary approach to complex surgical back wounds over culture data for wound closure timing.
C1 [VanDolah, Hunter B.; Li, Karen R.; Acuna, Kelly A.] Georgetown Univ, Sch Med, Washington, DC USA.
   [Kim, Kevin G.; Berger, Lauren E.; Attinger, Christopher E.; Fan, Kenneth L.; Evans, Karen K.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, 1st Floor,Bles Bldg,3800 Reservoir Rd Northwest, Washington, DC 20007 USA.
   [Tefera, Eshetu A.] MedStar Hlth Res Inst, Dept Biostat & Biomed Informat, Hyattsville, MD USA.
   [Evans, Karen K.] Ctr Wound Healing & Hyperbar Med, 1st Floor,Bles Bldg,3800 Reservoir Rd Northwest, Washington, DC 20007 USA.
C3 Georgetown University; Georgetown University; MedStar Health Research
   Institute
RP Evans, KK (通讯作者)，MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, 1st Floor,Bles Bldg,3800 Reservoir Rd Northwest, Washington, DC 20007 USA.; Evans, KK (通讯作者)，Ctr Wound Healing & Hyperbar Med, 1st Floor,Bles Bldg,3800 Reservoir Rd Northwest, Washington, DC 20007 USA.
EM hbv5@georgetown.edu; krl67@georgetown.edu; kevin.kim@nyulangone.org;
   lb557@rwjms.rutgers.edu; eshetu.tefera@medstar.net;
   ka798@georgetown.edu; christopher.attinger@medstar.net;
   kf293@georgetown.edu; Karen.K.Evans@gunet.georgetown.edu
OI VanDolah, Hunter/0000-0003-4302-5729
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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   Cross MB, 2014, J AM ACAD ORTHOP SUR, V22, P193, DOI 10.5435/JAAOS-22-03-193
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NR 28
TC 0
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2024
VL 92
IS 5
BP 569
EP 574
DI 10.1097/SAP.0000000000003883
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TG5Q8
UT WOS:001240130600001
PM 38685496
DA 2026-07-24
ER
PT J
AU Gialdini, C
   Chamillard, M
   Diaz, V
   Pasquale, J
   Thangaratinam, S
   Abalos, E
   Torloni, MR
   Betran, AP
AF Gialdini, Celina
   Chamillard, Monica
   Diaz, Virginia
   Pasquale, Julia
   Thangaratinam, Shakila
   Abalos, Edgardo
   Torloni, Maria Regina
   Betran, Ana Pilar
TI Evidence-based surgical procedures to optimize caesarean outcomes: an
   overview of systematic reviews
SO ECLINICALMEDICINE
LA English
DT Review
DE Caesarean section; Surgery; Public health; Systematic review; Maternal
   health
ID SECTION; DELIVERY; CLOSURE; HEALTH; IMPACT
AB Background Caesarean section (CS) is the most performed major surgery worldwide. Surgical techniques used for CS vary widely and there is no internationally accepted standardization. We conducted an overview of systematic reviews (SR) of randomized controlled trials (RCT) to summarize the evidence on surgical techniques or procedures related to CS. Methods Searches were conducted from database inception to 31 January 2024 in Cochrane Database of Systematic Reviews, PubMed, EMBASE, Lilacs and CINAHL without date or language restrictions. AMSTAR 2 and GRADE were used to assess the methodological quality of the SRs and the certainty of evidence at outcome level, respectively. We classi fi ed each procedure-outcome pair into one of eight categories according to effect estimates and certainty of evidence. The overview was registered at PROSPERO (CRD 42023208306). Findings The analysis included 38 SRs (16 Cochrane and 22 non -Cochrane) published between 2004 - 2024 involving 628 RCT with a total of 190,349 participants. Most reviews were of low or critically low quality (AMSTAR 2). The SRs presented 345 procedure-outcome comparisons (237 procedure versus procedure, 108 procedure versus no treatment/placebo). There was insuf fi cient or inconclusive evidence for 256 comparisons, clear evidence of bene fi t for 40, possible bene fi t for 17, no difference of effect for 13, clear evidence of harm for 14, and possible harm for 5. We found no SRs for 7 pre-de fi ned procedures. Skin cleansing with chlorhexidine, Joel-Cohen-based abdominal incision, uterine incision with blunt dissection and cephalad-caudal expansion, cord traction for placental extraction, manual cervical dilatation in pre -labour CS, changing gloves, chromic catgut suture for uterine closure, non-closure of the peritoneum, closure of subcutaneous tissue, and negative pressure wound therapy are procedures associated with bene fi ts for relevant outcomes. Interpretation Current evidence suggests that several CS surgical procedures improve outcomes but also reveals a lack of or inconclusive evidence for many commonly used procedures. There is an urgent need for evidence-based guidelines standardizing techniques for CS, and trials to fi ll existing knowledge gaps.
C1 [Gialdini, Celina; Chamillard, Monica; Diaz, Virginia; Pasquale, Julia] Ctr Rosarino Estudios Perinatales CREP, Rosario, Argentina.
   [Gialdini, Celina] Univ Ramon Llull, Fac Ciencies Salut Blanquerna, Barcelona, Spain.
   [Thangaratinam, Shakila] Univ Birmingham, Inst Metab & Syst Res, Birmingham, England.
   [Abalos, Edgardo] Ctr Estudios Estado & Soc CEDES, Buenos Aires, Argentina.
   [Torloni, Maria Regina] Sao Paulo Fed Univ, Dept Med, Evidence Based Healthcare Postgrad Program, Sao Paulo, Brazil.
   [Betran, Ana Pilar] World Hlth Org, UNDP UNFPA UNICEF WHO World Bank Special Programme, Dept Sexual & Reprod Hlth & Res, Geneva, Switzerland.
C3 Universitat Ramon Llull; University of Birmingham; Universidade Federal
   de Sao Paulo (UNIFESP); World Health Organization
RP Gialdini, C (通讯作者)，Ctr Rosarino Estudios Perinatales CREP, Rosario, Argentina.
EM cgialdini@crep.org.ar
RI Torloni, Maria Regina/IZP-5787-2023; Thangaratinam,
   Shakila/AAP-3724-2021
OI Gialdini, Celina/0009-0004-1150-2142; Abalos,
   Edgardo/0000-0001-6653-429X; Thangaratinam, Shakila/0000-0002-4254-460X
FU UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research,
   Development and Research Training in Human Reproduction (HRP); World
   Health Organization (WHO)
FX Financial support for conducting the overview was provided to Centro
   Rosarino de Estudios Perinatales (CREP) by UNDP-UNFPA-UNICEF-WHO-World
   Bank Special Programme of Research, Development and Research Training in
   Human Reproduction (HRP), a cosponsored programme executed by the World
   Health Organization (WHO).
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NR 72
TC 14
Z9 15
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-5370
J9 ECLINICALMEDICINE
JI EClinicalMedicine
PD JUN
PY 2024
VL 72
AR 102632
DI 10.1016/j.eclinm.2024.102632
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TW1Z6
UT WOS:001244218100001
PM 38812964
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, CL
   Hao, DS
   Wang, SJ
AF Wang, Chenliang
   Hao, Dongsheng
   Wang, Sijie
TI Management of calcific myonecrosis using vacuum sealing drainage: A rare
   case report and 5-year follow-up
SO ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
LA English
DT Article
DE Level IV; Therapeutic Study
ID LEG
AB Calcific myonecrosis (CM), a rare post-traumatic sequel of the lower limb, is characterized by calcified lesions. A diagnosis of CM can be difficult owing to the longtime span from the emergence of the original trauma to the onset of the symptoms of CM. This case report aimed to feature a case of a 55-year-old gentleman who presented with a progressive painful swelling in the anterolateral aspect of the right lower leg with the initial trauma arising 11 years ago. In the conservative treatment, a fluid-filled mass was formed. The histo-logical examination of the biopsy suggested a diagnosis of CM. The patient underwent a complete debridement operation, after which vacuum sealing drainage was used to manage the space left. Three weeks later, direct wound closure was achieved. Five-year follow-ups showed an excellent outcome without recurrence. Complete surgical debridement combined with primary closure is recommended to manage CM
C1 [Wang, Chenliang; Hao, Dongsheng; Wang, Sijie] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3, Taiyuan, Peoples R China.
C3 Shanxi Medical University
RP Hao, DS (通讯作者)，Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3, Taiyuan, Peoples R China.
EM 13426364680@163.com
RI Wang, Chengliang/JEZ-9556-2023; HAO, DONGSHENG/HHS-3378-2022
OI Wang, Chengliang/0000-0003-2208-3508; HAO, DONGSHENG/0000-0001-6518-3678
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NR 12
TC 0
Z9 0
U1 0
U2 0
PU TURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY
PI ISTANBUL
PA SEHREMINI MAH KOYUNCU SK CIGDEM APT NO 4 D 5 FATIH, ISTANBUL, 00000,
   Turkiye
SN 1017-995X
EI 2589-1294
J9 ACTA ORTHOP TRAUMATO
JI Acta Orthop. Traumatol. Turc.
PD MAR
PY 2024
VL 58
IS 2
DI 10.5152/j.aott.2024.22187
PG 66
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA UE6M7
UT WOS:001246424400010
PM 39128070
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ainslie-Garcia, M
   Anderson, LA
   Bloch, BV
   Board, TN
   Chen, AF
   Craigie, S
   Danker, W
   Gunja, N
   Harty, J
   Hernandez, VH
   Lebedeva, K
   Hameed, D
   Mont, MA
   Nunley, RM
   Parvizi, J
   Perka, C
   Piuzzi, NS
   Rolfson, O
   Rychlik, J
   Romanini, E
   Sanz-Ruiz, P
   Sierra, RJ
   Suleiman, L
   Tsiridis, E
   Vendittoli, PA
   Wangen, H
   Zagra, L
AF Ainslie-Garcia, Margaret
   Anderson, Lucas A.
   Bloch, Benjamin V.
   Board, Tim N.
   Chen, Antonia F.
   Craigie, Samantha
   Danker, Walter
   Gunja, Najmuddin
   Harty, James
   Hernandez, Victor H.
   Lebedeva, Kate
   Hameed, Daniel
   Mont, Michael A.
   Nunley, Ryan M.
   Parvizi, Javad
   Perka, Carsten
   Piuzzi, Nicolas S.
   Rolfson, Ola
   Rychlik, Joshua
   Romanini, Emilio
   Sanz-Ruiz, Pablo
   Sierra, Rafael J.
   Suleiman, Linda
   Tsiridis, Eleftherios
   Vendittoli, Pascal-Andr
   Wangen, Helge
   Zagra, Luigi
TI International Delphi Study on Wound Closure and Incision Management in
   Joint Arthroplasty Part 2: Total Hip Arthroplasty
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE total hip arthroplasty (THA); wound closure; incision management;
   modified Delphi study; consensus development; orthopaedic surgery
   practices
ID TOTAL KNEE ARTHROPLASTY; RISK CALCULATOR; INFECTION; CONSENSUS
AB Background: This modi fied Delphi study aimed to develop a consensus on optimal wound closure and incision management strategies for total hip arthroplasty (THA). Given the critical nature of wound care and incision management in in fluencing patient outcomes, this study sought to synthesize evidencebased best practices for wound care in THA procedures. Methods: An international panel of 20 orthopedic surgeons from Europe, Canada, and the United States evaluated a targeted literature review of 18 statements (14 speci fic to THA and 4 related to both THA and total knee arthroplasty). There were 3 rounds of anonymous voting per topic using a modi fied 5 -point Likert scale with a predetermined consensus threshold of >= 75% agreement necessary for a statement to be accepted. Results: After 3 rounds of voting, consensus was achieved for all 18 statements. Notable recommendations for THA wound management included (1) the use of barbed sutures over non -barbed sutures (shorter closing times and overall cost savings); (2) the use of subcuticular sutures over skin staples (lower risk of superficial infections and higher patient preferences, but longer closing times); (3) the use of mesh-adhesives over silver-impregnated dressings (lower rate of wound complications); (4) for at -risk patients, the use of negative pressure wound therapy over other dressings (lower wound complications and reoperations, as well as fewer dressing changes); and (5) the use of triclosan-coated sutures (lower risk of surgical site infection) over standard sutures. Conclusions: Through a structured modified Delphi approach, a panel of 20 orthopedic surgeons reached consensus on all 18 statements pertaining to wound closure and incision management in THA. This study provides a foundational framework for establishing evidence-based best practices, aiming to reduce variability in patient outcomes and to enhance the overall quality of care in THA procedures. (c) 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Ainslie-Garcia, Margaret; Craigie, Samantha; Lebedeva, Kate; Rychlik, Joshua] EVERSANA, Dept Value & Evidence, Burlington, ON, Canada.
   [Anderson, Lucas A.] Univ Utah, Orthopaed Ctr, Dept Orthopaed, Salt Lake City, UT USA.
   [Bloch, Benjamin V.] City Hosp, Dept Orthopaed, Nottingham Elective Orthopaed Serv, Nottingham, England.
   [Board, Tim N.] Wrightington Hosp, Ctr Hip Surg, Dept Orthopaed, Wigan, England.
   [Chen, Antonia F.] Harvard Med Sch, Brigham & Womens Hosp, Dept Orthopaed Surg, Boston, MA USA.
   [Danker, Walter; Gunja, Najmuddin] J&J MedTech, Hlth Econ & Market Access, Raritan, NJ USA.
   [Harty, James] Cork Univ Hosp, Trauma & Orthopaed Dept, Cork, Ireland.
   [Hernandez, Victor H.] Univ Miami, Jackson Mem Hosp, Dept Orthopaed Surg & Rehabil, Miami, FL USA.
   [Hameed, Daniel; Mont, Michael A.] Sinai Hosp Baltimore, Rubin Inst Adv Orthoped, LifeBridge Hlth, 2401 West Belvedere Ave, Baltimore, MD 21215 USA.
   [Nunley, Ryan M.] Washington Univ, Dept Orthopaed Surg, St Louis, MO USA.
   [Parvizi, Javad] Thomas Jefferson Univ, Rothman Inst, Philadelphia, PA USA.
   [Perka, Carsten] Orthopead Univ Klin Charite, Dept Orthopaed, Ctr Muskuloskeletale Chirurg, Berlin, Germany.
   [Piuzzi, Nicolas S.] Cleveland Clin Fdn, Dept Orthoped Surg, Cleveland, OH USA.
   [Rolfson, Ola] Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Orthopead, Gothenburg, Sweden.
   [Romanini, Emilio] Polo Sanitario San Feliciano, Ctr Hip & Knee Arthroplasty, Rome, Italy.
   [Sanz-Ruiz, Pablo] Univ Complutense Madrid UCM, Fac Med, Dept Surg, Madrid, Spain.
   [Sierra, Rafael J.] Mayo Clin, Dept Orthoped Surg, Rochester, MN USA.
   [Suleiman, Linda] Northwestern Univ, Dept Orthopaed Surg, Feinberg Sch Med, Chicago, IL USA.
   [Tsiridis, Eleftherios] Aristotle Univ Thessaloniki, Gen Hosp Papageorgiou, Acad Orthoped Unit, Med Sch, Thessaloniki, Greece.
   [Vendittoli, Pascal-Andr] Univ Montreal, Maisonneuve Rosemont Hosp, Dept Surg, Montreal, PQ, Canada.
   [Wangen, Helge] Innlandet Hosp Trust, Dept Orthopaed Surg, Elverum, Norway.
   [Zagra, Luigi] IRCCS Ist Ortoped Galeazzi, Hip Dept, Milan, Italy.
C3 Utah System of Higher Education; University of Utah; University of
   Nottingham; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; University
   College Cork; University of Miami; Sinai Hospital of Baltimore;
   Washington University (WUSTL); Rothman Institute; Thomas Jefferson
   University; Cleveland Clinic Foundation; University of Gothenburg;
   Complutense University of Madrid; Mayo Clinic; Northwestern University;
   Feinberg School of Medicine; Aristotle University of Thessaloniki;
   Papageorgiou Hospital; Universite de Montreal; Innlandet Hospital Trust;
   IRCCS Istituto Ortopedico Galeazzi
RP Mont, MA (通讯作者)，Sinai Hosp Baltimore, Rubin Inst Adv Orthoped, LifeBridge Hlth, 2401 West Belvedere Ave, Baltimore, MD 21215 USA.
RI Danker III, Walter/AAP-5078-2020; Zagra, Luigi/PFZ-1383-2026; Bloch,
   Benjamin/I-1041-2019; /I-9296-2019; Rolfson, Ola/AAT-2206-2020; Perka,
   Carsten/ABG-6505-2021; Hernandez, Victor H/AAG-4458-2020; sanz-ruiz,
   pablo/H-6539-2015
OI Danker III, Walter/0000-0002-9741-5821; Perka,
   Carsten/0000-0002-0993-581X; Piuzzi, Nicolas S/0000-0003-3007-7538;
   Hernandez, Victor H/0000-0003-1745-3324; sanz-ruiz,
   pablo/0000-0002-7588-1880
FU Ethicon
FX Funding: This project received financial support from Ethicon.
CR Antonelli B, 2019, ARTHROPLASTY, V1, DOI 10.1186/s42836-019-0003-7
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   Bozic KJ, 2013, CLIN ORTHOP RELAT R, V471, P574, DOI 10.1007/s11999-012-2605-z
   Bozic KJ, 2012, J BONE JOINT SURG AM, V94A, P794, DOI 10.2106/JBJS.K.00072
   Chen ZM, 2024, J KNEE SURG, V37, P238, DOI 10.1055/s-0043-1768248
   Chen ZM, 2022, J KNEE SURG, V35, P1524, DOI 10.1055/s-0042-1758674
   Chen Zhongming, 2022, SURGICAL TECHNOLOGY INTERNATIONAL-INTERNATIONAL DEVELOPMENTS IN SURGERY AND SURGICAL RESEARCH, V41
   Cizmic Z, 2019, J ARTHROPLASTY, V34, pS255, DOI 10.1016/j.arth.2018.09.010
   Crowe B, 2015, J ARTHROPLASTY, V30, P2275, DOI 10.1016/j.arth.2015.06.058
   Diamond IR, 2014, J CLIN EPIDEMIOL, V67, P401, DOI 10.1016/j.jclinepi.2013.12.002
   Emara AK, 2020, JAMA SURG, V155, P1009, DOI 10.1001/jamasurg.2020.1521
   Faour M, 2018, J KNEE SURG, V31, P858, DOI 10.1055/s-0037-1615812
   Faour M, 2018, J KNEE SURG, V31, P6, DOI 10.1055/s-0037-1608838
   Hameed D, 2023, Surg Technol Int, V43
   Hasson F, 2000, J ADV NURS, V32, P1008, DOI 10.1046/j.1365-2648.2000.01567.x
   Kurtz S, 2007, J BONE JOINT SURG AM, V89A, P780, DOI 10.2106/JBJS.F.00222
   Kurtz SM, 2012, J ARTHROPLASTY, V27, P61, DOI 10.1016/j.arth.2012.02.022
   Lychagin AV, 2021, HIP INT, V31, P589, DOI 10.1177/1120700020941749
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   Rothfusz CA, 2021, JBJS Rev, P9
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   Schwarz EM, 2019, J ORTHOP RES, V37, P997, DOI 10.1002/jor.24293
   Siddiqi A, 2021, J BONE JOINT SURG AM, V103, P1335, DOI 10.2106/JBJS.20.01184
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   Tan TL, 2018, J BONE JOINT SURG AM, V100, P777, DOI 10.2106/JBJS.16.01435
   Zmistowski B, 2013, J BONE JOINT SURG AM, V95A, P1869, DOI 10.2106/JBJS.L.00679
NR 27
TC 12
Z9 14
U1 0
U2 7
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD JUN
PY 2024
VL 39
IS 6
BP 1524
EP 1529
DI 10.1016/j.arth.2024.01.047
EA MAY 2024
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA UF6V0
UT WOS:001246692800001
PM 38325531
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Chan, SC
   Engkasan, JP
AF Chan, Soo Chin
   Engkasan, Julia Patrick
TI How Effective Is Negative Pressure Wound Therapy for Treating Pressure
   Ulcers?-A Cochrane Review Summary With Commentary
SO AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
LA English
DT Article
C1 [Chan, Soo Chin; Engkasan, Julia Patrick] Univ Malaya, Dept Rehabil Med, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya
RP Engkasan, JP (通讯作者)，Univ Malaya, Dept Rehabil Med, Kuala Lumpur 50603, Malaysia.
EM scchan@ummc.edu.my; julia@ummc.edu.my
RI Engkasan, Julia/M-5547-2018; Chan, Soo Chin/ABH-3086-2021
OI Chan, Soo Chin/0000-0002-9145-079X
CR Gould L, 2016, WOUND REPAIR REGEN, V24, P145, DOI 10.1111/wrr.12396
   Guy Heidi, 2012, Nurs Times, V108, P20
   Kottner J, 2019, J TISSUE VIABILITY, V28, P51, DOI 10.1016/j.jtv.2019.01.001
   Putnis Sven, 2014, Open Orthop J, V8, P142, DOI 10.2174/1874325001408010142
   Shi JY, 2023, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011334.pub3
   The Japanese Society of Pressure Ulcers Guideline Revision Committee, 2016, JPN J PU, V18, P455
NR 6
TC 0
Z9 0
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0894-9115
EI 1537-7385
J9 AM J PHYS MED REHAB
JI Am. J. Phys. Med. Rehabil.
PD JUL
PY 2024
VL 103
IS 7
BP 650
EP 651
DI 10.1097/PHM.0000000000002493
PG 2
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation; Sport Sciences
GA UH3T5
UT WOS:001247133600010
PM 38529617
DA 2026-07-24
ER
PT J
AU Matthews, MR
   Fernández, LG
   Hermans, MHE
   Chakravarthy, D
AF Matthews, Marc R.
   Fernandez, Luis G.
   Hermans, Michel H. E.
   Chakravarthy, Debashish
TI The Efficient Application of Instilling Negative Pressure Wound Therapy
   With a Hypochlorous Acid-Preserved Wound Cleanser: A Case Series and
   Practical Advice
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE debridement; pure hypochlorous acid; negative pressure wound therapy
   with instillation and dwell time
ID CLINICAL RECOMMENDATIONS; INSTILLATION; TRAUMA; DWELL; HOLES
AB Background. The use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been shown to be effective in removing nonviable tissue, reducing bioburden, and promoting granulation tissue formation in acute and chronic infected wounds. Objective. To illustrate the clinical efficacy of the use of pure hypochlorous acid (pHA) antimicrobially preserved wound cleansing solution as the instillation fluid for NPWTi-d (NPWTi-d/pHA) in wound bed preparation in patients with complex wounds. Case Report. The treatment protocol for use of NPWTi-d/pHA in preparing wound beds for final closure is demonstrated in 3 illustrative cases of patients with complex wounds resulting from necrotizing infection and trauma with heavy contamination. All 3 patients developed a healthy -appearing wound bed deemed suitable for primary closure an average of approximately 1 month following initial surgical debridement. Conclusion. The cases presented demonstrate the ability of a pHA antimicrobially preserved wound cleansing solution used as the instillation fluid with NPWTi-d to aid in bacterial reduction, mechanical debridement, and promotion of wound healing. Use of NPWTi-d/pHA in these cases of extensive necrotizing infection and posttraumatic injury with heavy contamination allowed for final closure an average of 1 month after initial surgical debridement.
C1 [Matthews, Marc R.] Banner Univ Arizona, Univ Med Ctr, Dept Surg, Div Trauma Surg Crit Care Burns & Acute Care Surg, Tucson, AZ USA.
   [Fernandez, Luis G.] Univ Texas Hlth Sci Ctr, Dept Surg, Div Trauma Surg Surg Crit Care, UT Hlth East Texas, Tyler, TX 75708 USA.
   [Hermans, Michel H. E.] Hermans Med Consulting, Hoorn, Netherlands.
   [Chakravarthy, Debashish] Urgo Med North Amer, Ft Worth, TX USA.
C3 University of Arizona; University of Texas System; University of
   Texas-Health Sciences Center at Tyler (UTHSCT); University of Texas at
   Tyler
RP Fernández, LG (通讯作者)，Univ Texas Hlth Sci Ctr, Dept Surg, Div Trauma Surg Surg Crit Care, UT Hlth East Texas, Tyler, TX 75708 USA.
EM luis.fernandez@uthct.edu
CR Alvarez PS, 2018, ANN MED SURG, V36, P246, DOI 10.1016/j.amsu.2018.10.007
   Anchalia Manjulata, 2020, Wounds, V32, pE84
   Anwar S, 2022, J PHARM BIOALLIED SC, V14, P796, DOI 10.4103/jpbs.jpbs_172_22
   Aycart Mario A, 2018, Cureus, V10, pe3377, DOI [10.7759/cureus.3377, 10.7759/cureus.3377]
   Biancari F, 2022, J CLIN MED, V11, DOI 10.3390/jcm11154268
   Blalock L, 2019, WOUNDS, V31, P55
   Block MS, 2020, J ORAL MAXIL SURG, V78, P1461, DOI 10.1016/j.joms.2020.06.029
   Chen L, 2021, ANN PALLIAT MED, V10, P10830, DOI 10.21037/apm-21-2476
   Cheng Y, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013710.pub2
   Chowdhry SA, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002087
   Collier M, 1997, Nurs Times, V93, P32
   Collinsworth AW, 2022, WOUNDS, V34, P269, DOI 10.25270/wnds/22013
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   Delapena Samantha, 2020, Wounds, V32, pE96
   Department of Surgery Christiana Care Health System Newark DE, 2020, Journal of Medical Science and Clinical Research, V08, DOI 10.18535/jmscr/v8i6.79
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   Fernández LG, 2020, WOUNDS, V32, P279
   Fernández LG, 2020, INT WOUND J, V17, P1829, DOI 10.1111/iwj.13471
   Fernández LG, 2020, WOUNDS, V32, P107
   Fernandez LG, 2019, CUREUS J MED SCIENCE, V11, DOI 10.7759/cureus.5667
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   Kapp DL, 2018, INT J LOW EXTR WOUND, V17, P295, DOI 10.1177/1534734618804037
   Kim PJ, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9047
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Leow Kimberley, 2020, Wounds, V32, pE120
   Lin DZ, 2021, INT WOUND J, V18, P112, DOI 10.1111/iwj.13500
   Matthews MR, 2022, WOUNDS, V34, P141, DOI 10.25270/wnds/082421.02
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   Matthews Marc R, 2018, Eplasty, V18, pe12
   McElroy EF, 2019, INT WOUND J, V16, P781, DOI 10.1111/iwj.13097
   McKanna M, 2016, OSTOMY WOUND MANAG, P3
   Onyekwelu I, 2017, JAAOS GLOB RES REV, V1, DOI 10.5435/JAAOSGlobal-D-17-00022
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   Voinchet V, 1996, Ann Chir Plast Esthet, V41, P583
   Wang L, 2007, J Burns Wounds, V6, pe5
   Wang YJ, 2022, INT WOUND J, V19, P573, DOI 10.1111/iwj.13654
NR 47
TC 3
Z9 3
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2024
VL 36
IS 5
BP 148
EP 153
DI 10.25270/wnds/21122
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA UJ1Y5
UT WOS:001247610900002
PM 38861209
DA 2026-07-24
ER
PT J
AU Aljehani, Y
   Alrashaid, F
   El-bawab, H
   Alkhaldi, N
   Alsadery, H
   Alayyaf, N
   Alsaikhan, J
   Alshamekh, S
AF Aljehani, Yasser
   Alrashaid, Farouk
   El-bawab, Hatem
   Alkhaldi, Naif
   Alsadery, Hmood
   Alayyaf, Norah
   Alsaikhan, Jana
   Alshamekh, Sumiyah
TI The Utility of Negative Pressure Wound Therapy in the Management of
   Complex Deep Cardiothoracic Surgical Site Infections
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE cardiothoracic; complex deep surgical site infection; empyema;
   mediastinitis; negative pressure wound therapy; NPWT
ID VACUUM-ASSISTED CLOSURE; SURGERY; EMPYEMA
AB Background. Complex deep surgical site infection in the cardiothoracic surgery patient that reaches the sternum and even the mediastinum, causing osteomyelitis and mediastinitis, is associated with high rates of morbidity and mortality. Negative pressure wound therapy (NPWT) can aid in achieving favorable outcomes in patients with complex surgical site infections by promoting wound healing and shortening the hospital stay. NPWT is widely recognized for its advantages and has recently been used in both cardiothoracic and non-cardiothoracic settings. Objective. To evaluate the efficacy of NPWT in the management of complex deep surgical site infection after cardiothoracic surgery. Materials and Methods. A retrospective chart review of all complex cardiothoracic cases admitted to the cardiac and thoracic surgery divisions for surgical intervention to treat postoperative surgical wound infections. Results. A total of 18 patients were included, with a male -to -female ratio of 5:4. The mean (SD) age was 48.7 (16.5) years. The cases reviewed were complex, and the duration of the NPWT application ranged from 4 days to 120 days, with an average hospital stay of 62.8 days. Seventyeight percent of patients required antibiotics (or had positive wound cultures); in 55.6% of these patients, polymicrobial infection was detected. No major complications were related to NPWT. Conclusion. The study findings show that using NPWT in complex deep sternal and thoracic infections can enhance wound healing, shorten the hospital stay, and decrease morbidity and mortality secondary to wound infection in cardiothoracic patients.
C1 [Aljehani, Yasser; Alrashaid, Farouk; El-bawab, Hatem; Alkhaldi, Naif; Alsadery, Hmood; Alayyaf, Norah; Alsaikhan, Jana; Alshamekh, Sumiyah] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Gen Surg, Dammam, Saudi Arabia.
   [Aljehani, Yasser] Imam Abdulrahman Bin Faisal Univ, King Fahd Hosp Univ, Gen Surg, Al Khobar 00000, Dammam, Saudi Arabia.
C3 Imam Abdulrahman Bin Faisal University; Imam Abdulrahman Bin Faisal
   University
RP Aljehani, Y (通讯作者)，Imam Abdulrahman Bin Faisal Univ, King Fahd Hosp Univ, Gen Surg, Al Khobar 00000, Dammam, Saudi Arabia.
EM yjehani@iau.edu.sa
RI Elbawab, Hatem/U-5996-2019
OI Elbawab, Hatem/0000-0003-0515-8221
CR Aljehani Y, 2016, CASE REP SURG, V2016, DOI 10.1155/2016/6805736
   Alreshaid F, 2022, J WOUND CARE, V31, pS5, DOI 10.12968/jowc.2022.31.Sup4.S5
   Aru GM, 2010, ANN THORAC SURG, V90, P266, DOI 10.1016/j.athoracsur.2010.04.092
   Chen Y, 2016, ONCOL LETT, V12, P757, DOI 10.3892/ol.2016.4654
   Christodoulou N, 2024, J PLAST RECONSTR AES, V94, P251, DOI 10.1016/j.bjps.2023.09.049
   Dezfuli B, 2013, WOUNDS, V25, P41
   Domjan Matic, 2023, Zdravniski Vestnik, V92, P437, DOI [10.6016/zdravvestn.3406, 10.6016/ZdravVestn.3406]
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   IJAR, 2017, International Journal of Advanced Research, V5, P1828, DOI [10.21474/ijar01/2952, 10.21474/IJAR01/2952, DOI 10.21474/IJAR01/2952]
   Karaaslan F, 2015, INT MED CASE REP J, V8, P7, DOI 10.2147/IMCRJ.S76214
   Kou Yuuki, 2021, Kyobu Geka, V74, P595
   Leggat PA, 2007, ANZ J SURG, V77, P209, DOI 10.1111/j.1445-2197.2007.04020.x
   Mahmoud AS, 2021, The Egyptian Journal of Hospital Medicine, V82, P37, DOI [10.21608/ejhm.2021.137573, 10.21608/ejhm.2021.137573, DOI 10.21608/EJHM.2021.137573]
   Palmen M, 2009, ANN THORAC SURG, V88, P1131, DOI 10.1016/j.athoracsur.2009.06.030
   Perez D, 2007, J AM COLL SURGEONS, V205, P586, DOI 10.1016/j.jamcollsurg.2007.05.015
   Rocco G, 2014, ANN THORAC SURG, V98, P291, DOI 10.1016/j.athoracsur.2014.04.022
   Saadi A, 2011, ANN THORAC SURG, V91, P1582, DOI 10.1016/j.athoracsur.2011.01.018
   Sherman G, 2020, PEDIATR CRIT CARE ME, V21, P150, DOI 10.1097/PCC.0000000000002131
   Tan Y, 2011, ARCH ORTHOP TRAUM SU, V131, P255, DOI 10.1007/s00402-010-1197-x
   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
   Wu CC, 2015, ADV SKIN WOUND CARE, V28, P21, DOI 10.1097/01.ASW.0000459038.81701.fb
NR 23
TC 0
Z9 0
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2024
VL 36
IS 5
BP 170
EP 176
DI 10.25270/wnds/23133
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA UJ1Y5
UT WOS:001247610900006
PM 38861213
DA 2026-07-24
ER
PT J
AU Freire, M
   Job, C
   Hassanpour, I
   Benito, J
   Pang, DSJ
   Paquet, M
   Theoret, CL
AF Freire, Mila
   Job, Chloe
   Hassanpour, Ida
   Benito, Javier
   Pang, Daniel S. J.
   Paquet, Marilene
   Theoret, Christine L.
TI A disposable, canister-free negative-pressure wound therapy device
   proves feasible, but of inferior efficacy to conventional therapies for
   treating cutaneous wounds in dogs
SO AMERICAN JOURNAL OF VETERINARY RESEARCH
LA English
DT Article
AB OBJECTIVE To assess the feasibility of a canister -free negative -pressure wound therapy (NPWT) device (PICOTM 1.6, Smith & Nephew Medical Ltd) and evaluate its effect on early phases of wound healing in canine experimental cutaneous wounds. ANIMALS 5 adult spayed female research Beagles. PROCEDURES In a pilot experimental study, 1 full -thickness 2 -cm X 2 -cm cutaneous wound was surgically created on each hemi - thorax in each dog. Wounds were treated with either NPWT or a conventional wound dressing for 14 days. Bandage changes and wound evaluations were done at 7 time points. First macroscopic appearance of granulation tissue, smoothness of granulation tissue, and percentages of wound contraction and epithelialization were compared between treatments. Wounds were sampled at 3 time points for histopathologic analyses and semiquantitative scoring. RESULTS NPWT dressings were well tolerated by all dogs. Complete seal of the dressing required the application of adhesive spray, and maintenance of the vacuum lessened over time. Self-limiting skin irritations appeared in all dogs and hampered the attainment of negative pressure. Granulation tissue developed faster and was more abundant in con - trol wounds. Wound contraction, epithelialization, and fibroblast proliferation were greater in control wounds at the end of the study. CLINICAL RELEVANCE This canister -free NPWT device is feasible but problematic in maintaining a vacuum, requiring frequent revisions of the dressing. Further studies are necessary to evaluate the effect of this device on early phases of wound healing. Its benefits in wound healing remain unknown.
C1 [Freire, Mila; Job, Chloe; Hassanpour, Ida; Benito, Javier] Univ Montreal, Fac Vet Med, Dept Clin Sci, St Hyacinthe, PQ, Canada.
   [Pang, Daniel S. J.] Univ Calgary, Fac Vet Med, Calgary, AB, Canada.
   [Paquet, Marilene] Univ Montreal, Fac Vet Med, Dept Pathol & Microbiol, St Hyacinthe, PQ, Canada.
   [Theoret, Christine L.] Univ Montreal, Fac Vet Med, Dept Biomed Sci, St Hyacinthe, PQ, Canada.
C3 Universite de Montreal; University of Calgary; Universite de Montreal;
   Universite de Montreal
RP Freire, M (通讯作者)，Univ Montreal, Fac Vet Med, Dept Clin Sci, St Hyacinthe, PQ, Canada.
EM m.freire.gonzalez@umontreal.ca
RI ; Paquet, Marilène/L-3414-2019; Benito de la Víbora,
   Javier/AEX-9842-2022; Pang, Daniel/B-8291-2013; /C-7320-2015
OI Freire, Mila/0000-0002-0410-8321; Paquet, Marilène/0000-0002-3562-4636;
   Benito de la Víbora, Javier/0000-0002-8174-1278; Job,
   chloé/0000-0001-8689-0259; 
FU Zoetis Clinical Research Funds of the Faculty of Veterinary Medicine of
   the Universite de Montreal
FX This study was supported by the Zoetis Clinical Research Funds of the
   Faculty of Veterinary Medicine of the Universite de Montreal and an
   in-kind donation from Smith & Nephew Canada. The authors declare there
   were no conflicts of interest and the funders had no role in the
   conception or execution of the study.
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NR 22
TC 0
Z9 1
U1 0
U2 2
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0002-9645
EI 1943-5681
J9 AM J VET RES
JI Am. J. Vet. Res.
PD OCT
PY 2022
VL 83
IS 10
AR 0029
DI 10.2460/ajvr.22.02.0029
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA VN9AS
UT WOS:001248227800019
PM 35973001
OA gold
DA 2026-07-24
ER
PT J
AU Sun, YW
AF Sun, Yanwei
TI Antibiotic-Loaded Bone Cement Combined with Negative Pressure Wound
   Therapy for Treating Sacrococcygeal Wound Following Sacral Chordoma
   Resection: A Case Report
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Case Report; Antibiotic-Loaded Bone Cement; Ne g ative Pressure Wound
   Thera py; Wound; Sacrococc yg eal Chordoma; nthetic Dura Substitutes
ID FLAP; RECONSTRUCTION; MANAGEMENT; CLOSURE
AB BACKGROUND: Sacral chordoma is a rare, malignant primary bone tumor with subtle clinical manifestations. The extensive cavity and soft tissue defect after radical resection of the tumor can lead to complications such as sacrococcygeal skin necrosis, infection, cerebrospinal fluid (CSF) leakage, and delayed healing or nonhealing. PURPOSE: To describe the treatment effect of the combination use of antibiotic-loaded bone cement (ALBC), a gluteus maximus muscle flap, and negative pressure wound therapy (NPWT) on the nonhealing sacrococcygeal wound after sacral chordoma resection. CASE REPORT: A 67-year-old woman with a sacrococcygeal wound following sacral chordoma resection was admitted to the hospital. In the 2 -stage surgery, the internal fixation and synthetic dura substitute were exposed and CSF leakage was found after debridement, a gluteus maximus muscle flap was used to cover the synthetic dura substitute to address the CSF leakage, ALBC was used to cover the internal fixation, and a modified NPWT system was fixed to the wound for improved flushing and drainage. RESULTS: The previously nonhealing wound healed 3 weeks postoperatively, and satisfactory recovery was achieved by 6-month follow-up. CONCLUSION: This case report suggests that the combination use of ALBC, gluteus maximus muscle flap, and NPWT can effectively promote sacrococcygeal wound healing after chordoma resection.
C1 [Sun, Yanwei] Zibo Cent Hosp, Dept Burns & Plast Surg, 54 Gong Qing Tuan Xi Rd, Zibo 255036, Shandong, Peoples R China.
RP Sun, YW (通讯作者)，Zibo Cent Hosp, Dept Burns & Plast Surg, 54 Gong Qing Tuan Xi Rd, Zibo 255036, Shandong, Peoples R China.
EM syanwei005@163.com
RI sun, yanwei/LFS-0201-2024
CR Alan Ozkan, 2018, J Med Case Rep, V12, P239, DOI [10.1186/s13256-018-1784-y, 10.1186/s13256-018-1784-y]
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD NOV
PY 2023
VL 69
IS 4
AR 23008
DI 10.25270/wmp.23008
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA UZ5V3
UT WOS:001251908600004
PM 38118069
DA 2026-07-24
ER
PT J
AU Bobkiewicz, A
   Francuzik, W
   Martinkosky, A
   Borejsza-Wysocki, M
   Ledwosinski, W
   Szmyt, K
   Banasiewicz, T
   Krokowicz, L
AF Bobkiewicz, Adam
   Francuzik, Wojciech
   Martinkosky, Amy
   Borejsza-Wysocki, Maciej
   Ledwosinski, Witold
   Szmyt, Krzysztof
   Banasiewicz, Tomasz
   Krokowicz, Lukasz
TI Negative Pressure Level and Effects on Bacterial Growth Kinetics in an
   in vitro Wound Model
SO POLISH JOURNAL OF MICROBIOLOGY
LA English
DT Article
DE negative pressure wound therapy; bacterial growth; wound healing;
   bioburden
ID VACUUM-ASSISTED CLOSURE; THERAPY; RECOMMENDATIONS
AB Negative Pressure Wound Therapy (NPWT) has been widely adopted in wound healing strategies due to its multimodal mechanism of action. While NPWT's positive impression on wound healing is well-established, its effect on bacterial load reduction remains equivocal. This study investigates NPWT's efficacy in reducing bioburden using an in vitro porcine skin model, focusing on the impact of Staphylococcus aureus and Staphylococcus epidermidis. Custom-made negative pressure chambers were employed to apply varying negative pressures. Porcine skin was cut into 5 x 5 cm squares and three standardized wounds of 6 mm each were created using a biopsy punch. Then, wounds were infected with S. aureus and S. epidermidis bacterial suspensions diluted 1:10,000 to obtain a final concentration of 1.5 x 10(4) CFU/ml and were placed in negative pressure chambers. After incubation, bacterial counts were expressed as colony-forming units (CFU) per ml. For S. aureus at 120 hours, the median CFU, mean area per colony, and total growth area were notably lower at -80 mmHg when compared to -250 mmHg and -50 mmHg, suggesting an optimal negative pressure for the pressure-dependent inhibition of the bacterial proliferation. While analyzing S. epidermidis at 120 hours, the response to the negative pressure was similar but less clear, with the minor CFU at -100 mmHg. The influence of intermittent negative pressure on the S. epidermidis growth showed notably lower median CFU with the interval therapy every hour compared to the S. aureus control group. This study contributes valuable insights into NPWT's influence on the bacterial load, emphasizing the need for further research to reformulate its role in managing contaminated wounds.
C1 [Bobkiewicz, Adam; Martinkosky, Amy; Borejsza-Wysocki, Maciej; Ledwosinski, Witold; Szmyt, Krzysztof; Banasiewicz, Tomasz; Krokowicz, Lukasz] Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Poznan, Poland.
   [Francuzik, Wojciech] Charite Univ Med Berlin, Dept Dermatol Venerol & Allergol, Berlin, Germany.
C3 Poznan University of Medical Sciences; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin
RP Krokowicz, L (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Poznan, Poland.
EM lkrokowicz@gmail.com
RI Francuzik, Wojciech/H-6773-2019
OI Francuzik, Wojciech/0000-0001-5361-9876
CR Anagnostakos K, 2012, J WOUND CARE, V21, P333, DOI 10.12968/jowc.2012.21.7.333
   Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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   Schneider CA, 2012, NAT METHODS, V9, P671, DOI 10.1038/nmeth.2089
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NR 32
TC 7
Z9 7
U1 0
U2 3
PU POLSKIE TOWARZYSTWO MIKROBIOLOGOW-POLISH SOCIETY OF MICROBIOLOGISTS
PI WARSAW
PA BANACHA 1 B, WARSAW, POLAND
SN 1733-1331
EI 2544-4646
J9 POL J MICROBIOL
JI Pol. J. Microbiol.
PD JUN 1
PY 2024
VL 73
IS 2
BP 199
EP 206
DI 10.33073/pjm-2024-018
PG 8
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA WA6N2
UT WOS:001252187800012
PM 38905277
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jing, G
   Wang, LL
AF Jing, Gang
   Wang, LinLin
TI Repairing Exposed Tendon Wounds with Absorbable Gelatin Sponges and
   Autologous Split-Thickness Skin Grafts: A Case Series
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE absorbable gelatin sponge; debridement; necrosis; negative-pressure
   wound therapy; repair; skin grafting; tendon exposure; wounds
ID FIBROBLAST-GROWTH-FACTOR; ARTIFICIAL SKIN; RECONSTRUCTION; EFFICACY;
   RELEASE; DERMIS
AB Conventional flap repair surgery has several drawbacks, including operational complexity, donor site damage, and high risk. In this case series, the authors explored an alternative approach for repairing exposed tendon wounds caused by trauma using absorbable gelatin sponges (AGSs) and autologous thigh skin grafts. This report presents two cases of lower-extremity skin necrosis with tendon exposure following wound debridement. The treatment approach involved early debridement, negative-pressure wound therapy, and wound irrigation with 0.9% sodium chloride. Upon achieving controlled wound infection, AGSs were applied to the exposed tendon to prevent degeneration and promote wound healing. Subsequently, areas where granulation tissue failed to cover the tendon were repaired using AGSs and 0.25-mm-thick autologous mesh skin grafts harvested from the thigh. Complete wound healing was achieved in both cases, on the 20th and 12th day after skin grafting, respectively. The proposed method proved successful in repairing exposed tendon wounds, effectively preventing infection and necrosis.
C1 [Jing, Gang] Hainan Med Univ, Hainan Gen Hosp, Hainan Affiliated Hosp, Dept Burn & Skin Repair Surg, Hainan, Peoples R China.
   [Wang, LinLin] Hainan Med Univ, Hainan Gen Hosp, Hainan Affiliated Hosp, Hainan, Peoples R China.
C3 Hainan Medical University; Hainan Medical University
RP Jing, G (通讯作者)，Hainan Med Univ, Hainan Gen Hosp, Hainan Affiliated Hosp, Dept Burn & Skin Repair Surg, Hainan, Peoples R China.
EM jg851212@126.com; 115212944@qq.com
OI Jing, gang/0009-0004-9514-6439
FU Hainan Provincial Natural Science Foundation of China [822QN449];
   National Natural Science Fund Cultivating 530 Project of Hainan General
   Hospital [2021QNXM02]; Courtyard's Level Program of Hainan General
   Hospital [QN202012]
FX This work was funded by the Hainan Provincial Natural Science Foundation
   of China (822QN449), the National Natural Science Fund Cultivating 530
   Project of Hainan General Hospital (2021QNXM02), and the Courtyard's
   Level Program of Hainan General Hospital (QN202012).
CR He JK, 2007, POLYMER, V48, P4578, DOI 10.1016/j.polymer.2007.05.048
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   Zajicek R, 2020, J WOUND CARE, V29, P458, DOI 10.12968/jowc.2020.29.8.458
   Zhao YF, 2019, J MATER CHEM B, V7, P1855, DOI 10.1039/c8tb03181a
   Zhu CT, 2019, J CELL BIOCHEM, V120, P12182, DOI 10.1002/jcb.28588
NR 19
TC 0
Z9 0
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUL
PY 2024
VL 37
IS 7
BP 6
EP 6
DI 10.1097/ASW.0000000000000166
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA WC3W1
UT WOS:001252639900009
PM 38899825
OA hybrid
DA 2026-07-24
ER
PT J
AU Oshima, J
   Kamma, T
   Inoue, Y
   Shibuya, Y
   Sasaki, K
   Sekido, M
AF Oshima, Junya
   Kamma, Taiki
   Inoue, Yoshiaki
   Shibuya, Yoichiro
   Sasaki, Kaoru
   Sekido, Mitsuru
TI Hydrocolloid Wound Dressing for Sealing Periwound With Poor Normal Skin:
   Negative Pressure Wound Therapy for Deep Limb Burns With Extensive Burns
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE burn; hydrocolloid wound dressing; negative pressure wound therapy
AB BACKGROUND: Negative pressure wound therapy (NPWT) is effective for wounds with exposed bones and tendons, but when the wound is accompanied by extensive burns, sealing is difficult. The authors performed sealing with a hydrocolloid wound dressing on limb burns. CASE REPORT: A 61-year-old woman was burned in a fire at her home. Split-thickness skin grafting was performed 14- and 35-days post-injury, but exposure of the right patella and patellar tendon became apparent. The hydrocolloid wound dressing was wrapped around the proximal and distal aspects of a deep wound. The limb was sandwiched from the front and back surfaces and sealed with 2 film dressings, including the hydrocolloid, according to the sandwich method. Using this method, NPWT could be performed without leakage, the exposed tendons and bones were covered with granulation, and skin grafts were performed on day 88 after injury. CONCLUSION: This method allows NPWT to be easily and effectively performed for deep limb burns with poor normal skin periwound area.
C1 [Oshima, Junya; Kamma, Taiki; Shibuya, Yoichiro; Sasaki, Kaoru; Sekido, Mitsuru] Univ Tsukuba, Dept Plast Reconstruct & Hand Surg, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan.
   [Inoue, Yoshiaki] Univ Tsukuba, Dept Emergency & Crit Care Med, Tsukuba, Ibaraki, Japan.
C3 University of Tsukuba; University of Tsukuba
RP Oshima, J (通讯作者)，Univ Tsukuba, Dept Plast Reconstruct & Hand Surg, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan.
EM ooshima-tuk@umin.ac.jp
CR Kantak NA, 2017, CLIN PLAST SURG, V44, P671, DOI 10.1016/j.cps.2017.02.023
   Niimi Y, 2021, JPRAS OPEN, V30, P156, DOI 10.1016/j.jpra.2018.08.001
   Oshima J, 2022, J BURN CARE RES, V43, P479, DOI 10.1093/jbcr/irab228
   Sahin I, 2012, Ann Burns Fire Disasters, V25, P92
NR 4
TC 0
Z9 0
U1 0
U2 5
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD SEP
PY 2023
VL 69
IS 3
BP 25
EP +
DI 10.25270/wmp.22095
PG 4
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA WG0L5
UT WOS:001253597800003
PM 38052012
DA 2026-07-24
ER
PT J
AU Luo, MY
   Ding, YS
   Qu, ZJ
   Feng, WY
   Lu, XH
AF Luo, Manyu
   Ding, Yushuang
   Qu, Zhijie
   Feng, Wenyuan
   Lu, Xuehong
TI Application of vacuum-sealing drainage in buttonhole-related
   arteriovenous fistula infection: A case report
SO HEMODIALYSIS INTERNATIONAL
LA English
DT Article
DE arteriovenous fistula infection; buttonhole cannulation; vacuum-sealing
   drainage
ID CANNULATION; SAFETY
AB Few studies have reported the application of vacuum-sealing drainage of infected dialysis vascular access wounds. Herein, we present a case of buttonhole-related arteriovenous fistula infection treated with vacuum-sealing drainage. A 53-year-old female hemodialysis patient was hospitalized with an inflamed arteriovenous fistula. The patient underwent non-tunneled catheterization for dialysis and was treated with moxifloxacin and vancomycin for staphylococcal infection. On Day 3, the skin overlying the inflamed fistula was ulcerated, resulting in severe hemorrhage. Emergency surgery was performed along with vacuum-sealing drainage for fistula reconstruction. Vacuum-sealing drainage accelerated the recovery of the wound without complications. No further access complications occurred during over a 3-year follow-up.
C1 [Luo, Manyu; Lu, Xuehong] Second Hosp Jilin Univ, Dept Nephropathy, Changchun 130041, Jilin, Peoples R China.
   [Ding, Yushuang] Second Hosp Jilin Univ, Dept Radiotherapy, Changchun, Jilin, Peoples R China.
   [Qu, Zhijie; Feng, Wenyuan] Second Hosp Jilin Univ, Blood Purificat Ctr, Dept Nephropathy, Changchun, Jilin, Peoples R China.
C3 Jilin University; Jilin University; Jilin University
RP Lu, XH (通讯作者)，Second Hosp Jilin Univ, Dept Nephropathy, Changchun 130041, Jilin, Peoples R China.
EM changchunlxh@foxmail.com
FU Jilin Education Department [JJKH20190003KJ]; Jilin Science and
   Technology Department [20200201564JC]
FX Jilin Education Department, Grant/Award Number: Project JJKH20190003KJ;
   Jilin Science and Technology Department, Grant/Award Number: Project
   20200201564JC
CR Huang SHS, 2019, CLIN J AM SOC NEPHRO, V14, P403, DOI 10.2215/CJN.08310718
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NR 12
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1492-7535
EI 1542-4758
J9 HEMODIAL INT
JI Hemodial. Int.
PD OCT
PY 2024
VL 28
IS 4
BP 456
EP 459
DI 10.1111/hdi.13164
EA JUN 2024
PG 4
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA J4D2H
UT WOS:001253896500001
PM 38924346
OA Bronze
DA 2026-07-24
ER
PT J
AU Christodoulou, N
   Wolfe, B
   Mathes, DW
   Malgor, RD
   Kaoutzanis, C
AF Christodoulou, Neophytos
   Wolfe, Brandon
   Mathes, David W.
   Malgor, Rafael D.
   Kaoutzanis, Christodoulos
TI Vacuum-assisted closure therapy for the management of deep sternal wound
   complications: A systematic review and meta-analysis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Vacuum-assisted closure; Deep sternal wound complications;
   Mediastinitis; Osteomyelitis; Sternal dehiscence
ID DIABETIC FOOT ULCERS; CARDIAC-SURGERY; SUCTION DRAINAGE; RISK-FACTORS;
   PRESSURE; INFECTION; MEDIASTINITIS; STERNOTOMY; MORTALITY;
   RECONSTRUCTION
AB stay and cost of treatment Background: Vacuum -assisted closure (VAC ) therapy has become a popular treatment option for wound healing. The aim of this meta -analysis was to assess the use of VAC therapy as a bridge before the definitive treatment for the management of deep sternal wound complications. Methods: A systematic literature review and meta -analysis were performed in PubMed and Embase. Outcomes of interest included mortality, treatment failure, length of hospital stay (LOS ), length of intensive care unit (ICU ) stay and cost of treatment. Results: Twenty -two studies involving 1980 patients were included in the quantitative synthesis of this meta -analysis. Patients treated with VAC had significantly lower overall mortality [1738 patients; Risk ratio [RR ] = 0.36 (95% confidence interval [CI ]: 0.25, 0.51 )], treatment failure [1210 patients; RR = 0.26 (95% CI: 0.19, 0.37 )], LOS [498 patients; (standard mean difference = -0.44 (95% CI: -0.81, -0.07 )] and ICU stay [309 patients; (standard mean difference = -0.34 (95% CI: -0.67, -0.01 )] compared to that of non -VAC patients. VAC therapy was associated with reduced cost of treatment per patient compared with that of non -VAC therapies (reductions of 3600 USD, 6000 USD and 8983 USD in the reported studies ). Conclusions: VAC therapy as an adjunct in the definitive treatment of patients with deep sternal wound complications was associated with lower mortality, treatment failure, LOS, ICU when compared with a non -VAC approach. Randomised controlled trials would be essential to confirm these findings. (c) 2023 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Christodoulou, Neophytos] Royal Papworth Hosp, Papworth Rd, Cambridge, England.
   [Wolfe, Brandon] Univ Colorado Anschutz Med Campus, Sch Med, Aurora, CO USA.
   [Kaoutzanis, Christodoulos] Univ Colorado Anschutz Med Campus, Dept Surg, Div Plast & Reconstruct Surg, Aurora, CO USA.
   [Malgor, Rafael D.] Univ Colorado, Anschutz Med Ctr, Div Vasc Surg & Endovascular Therapy, Aurora, CO USA.
C3 Papworth Hospital; University of Colorado System; University of Colorado
   Anschutz; University of Colorado System; University of Colorado
   Anschutz; University of Colorado System; University of Colorado Anschutz
RP Kaoutzanis, C (通讯作者)，Acad Off AO1, 12631 East 17th Ave,Mail Stop C309, Aurora, CO 80045 USA.
EM ckaoutzanis@gmail.com
OI Christodoulou, Neophytos/0000-0002-5425-8686; Kaoutzanis,
   Christodoulos/0000-0002-5631-8355
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NR 52
TC 5
Z9 6
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JUL
PY 2024
VL 94
BP 251
EP 260
DI 10.1016/j.bjps.2023.09.049
EA JUN 2024
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WI3Z2
UT WOS:001254214300001
PM 37951723
DA 2026-07-24
ER
PT J
AU Lin, KC
   Huang, FT
   Chen, CY
   Tarng, YW
AF Lin, Kai-Cheng
   Huang, Fu-Ting
   Chen, Chun-Yu
   Tarng, Yih-Wen
TI Is Staged Surgery Always Necessary for Schatzker Type IV-VI Tibial
   Plateau Fractures? A Comparison Study
SO LIFE-BASEL
LA English
DT Article
DE tibia plateau fracture; external fixation; open reduction and internal
   fixation; closed-incision negative-pressure therapy; negative-pressure
   wound therapy; outcome assessment
ID NEGATIVE-PRESSURE THERAPY; WOUND THERAPY; FIXATION; COMPLICATIONS;
   EFFICACY
AB Aims: This study aims to compare the outcomes of immediate (followed by closed-incision negative-pressure therapy use) versus delayed ORIF in patients with Schatzker type IV-VI TPFs. Patients and Methods: A prospective study of patients undergoing ORIF between January 2018 and December 2019 was performed. The inclusion criteria were patients (>18 years) with a closed fracture sent to the emergency room (ER) within 24 h of injury. All the patients underwent preoperative image evaluation. Two senior orthopedic trauma surgeons evaluated the soft tissue condition in the ER by 5P's of the compartment syndrome, judging the timing of the operation of definitive ORIF. Group 1 (n = 16) received delayed ORIF. Group 2 (n = 16) received immediate ORIF and ciNPT use. Patient follow-up occurred after 2 and 6 weeks and 3, 6, and 12 months after surgery. The assessments included the time to definitive fixation, the length of hospital stay, the time to bone union, surgical site complications, and reoperation within 12 months. A universal goniometer was used to measure the postoperative 3 m, 6 m, and 12 m ROM. Results: The patient demographics were similar between the groups (p > 0.05). Group 2 displayed significantly a shorter time to definitive fixation (5.94 +/- 2.02 vs. 0.61 +/- 0.28, p < 0.0001) and hospital stay (14.90 +/- 8/78 vs. 10.30 +/- 6.78, p = 0.0016). No significant difference was observed in the time to bone union, surgical site complication incidence, and reoperation rates (p > 0.05). Flexion and flexion-extension knee ROM were demonstrated to be significantly improved in Group 2, 3, 6, and 12 months postoperatively (p < 0.0001). Conclusions: In this study, early ORIF and ciNPT use resulted in a shorter hospital length of stay, a reduced time to early active motion of the knee, and improved knee ROM. These results suggest that early ORIF with ciNPT for Schatzker type IV-VI TPFs is safe and effective in some patients. However, further research to confirm these findings across larger and more diverse populations is needed.
C1 [Lin, Kai-Cheng; Huang, Fu-Ting; Chen, Chun-Yu; Tarng, Yih-Wen] Kaohsiung Vet Gen Hosp, Dept Otolaryngol, Kaohsiung 813, Taiwan.
C3 Kaohsiung Veterans General Hospital
RP Lin, KC; Huang, FT (通讯作者)，Kaohsiung Vet Gen Hosp, Dept Otolaryngol, Kaohsiung 813, Taiwan.
EM kclin@vghks.gov.tw; fuhuangl@vghks.gov.tw; cychen@vghks.gov.tw;
   ywtrang@vghks.gov.tw
FX We thanks 3M Company (San Antonio, TX, USA) for their aids in this
   study.
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NR 26
TC 2
Z9 5
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JUN
PY 2024
VL 14
IS 6
AR 753
DI 10.3390/life14060753
PG 11
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA WV6K4
UT WOS:001257685000001
PM 38929737
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hou, TJ
   Swee, TT
   Hiik, KLC
   Saad, AZM
   Malik, SA
AF Hou, Tan Jia
   Swee, Tan Tian
   Hiik, Kelvin Ling Chia
   Saad, Arman Zaharil Mat
   Malik, Sameen Ahmed
TI Two-N input output mapping relationship fuzziness adaptation approach
   for fuzzy based negative pressure wound Therapy system
SO EXPERT SYSTEMS WITH APPLICATIONS
LA English
DT Article
DE Negative pressure wound therapy; Limitation of fuzziness setting; Two
   relationship equation fuzziness adaptation; approach
AB Negative Pressure Wound Therapy (NPWT) is a vacuum assisted wound therapy technique. It has been widely applied for the chronic wound treatment due to its excellent performance on the wound healing promoting. However, there are several NPWT related cases which are caused by the unstable regulation of negative pressure have been reported. This has shown that there is a need to improve the performance of NPWT for reducing the NPWT wound injuries cases. Based on the review, the performance of NPWT is able to be improved with the incorporation of Fuzzy Logic based Negative Pressure Regulator (FL-NPR) but there are difficulties in the development of appropriate fuzzy sets setting for FL-NPR. This limitation could significantly affect the fuzziness of the algorithm and performance of NPWT. In this research, the Two Relationship Equation (2(n)RE) Fuzziness Adaptation approach for improving the performance of NPWT has been proposed. It is developed based on the theory of three-valued logic which can be applied for resolving the limitation of Classical Controller (CC). A set of Fuzzy based NPWT system with artificial wound model have been successfully developed with the support of experienced plastic surgeon. The research experiment of Fuzzy based NPWT with the proposed 2(n)RE Fuzziness Adaptation approach have been carried out. Based on the result obtained, it is clearly shown that the performance of NPWT can be significantly affected by the different fuzziness layer. The percentage of +/- 1 Tolerant Band achieved by the NPWT with 4RE FL-NPR is the highest where this result obtained is proving that the capability of wound healing process promoting of NPWT with 4RE FL-NPR is the highest. Furthermore, the percentage of undershoot achieved by the NPWT with 4RE FL-NPR is the lowest in which it is showing that its risk of low angiogenesis and wound healing failure is the lowest. According to the result obtained, the performance and safety feature of NPWT with 4RE FL-NPR is relatively better than that of 6RE FL-NPR and 8RE FL-NPR. In this research, the proposed 2(n)RE Fuzziness Adaptation approach for improving the performance and safety feature of NPWT have been successfully demonstrated and it is applicable for resolve the limitation of FL algorithm.
C1 [Hou, Tan Jia] Inst Engn & Technol, Stevenage, Herts, England.
   [Swee, Tan Tian; Hiik, Kelvin Ling Chia] Univ Teknol Malaysia, Fac Engn, Sch Biomed Engn & Hlth Sci, Johor Baharu, Malaysia.
   [Saad, Arman Zaharil Mat] Management & Sci Univ, Management & Sci Univ Hosp, Shah Alam, Malaysia.
   [Malik, Sameen Ahmed] Univ Engn & Technol Lahore, Fac Elect Engn, Dept Biomed Engn, Narowal Campus Narowal, Lahore 51600, Punjab, Pakistan.
C3 Universiti Teknologi Malaysia; Management Science University; University
   of Engineering & Technology Lahore
RP Hou, TJ (通讯作者)，Inst Engn & Technol, Stevenage, Herts, England.
EM jhtan@sc.edu.my; tantswee@biomedical.utm.my; lchkelvin2@live.utm.my;
   armanzaharil@gmail.com; sameen.ahmed@uet.edu.pk
RI Tan, Tian/G-6916-2013; Malik, Sameen/PJE-8009-2026; Ling Chia Hiik,
   Kelvin/AAW-9676-2021
OI Tan, Jia Hou/0000-0002-2419-5530; Ling Chia Hiik,
   Kelvin/0000-0003-1445-0507
FU Universiti Teknologi Malaysia and Management and Science University
FX This research did not receive any specific grant from funding agencies
   in the public, commercial, or not-for-profit sectors. The authors are
   grateful to the support provided by Universiti Teknologi Malaysia and
   Management and Science University.
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NR 34
TC 1
Z9 1
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0957-4174
EI 1873-6793
J9 EXPERT SYST APPL
JI Expert Syst. Appl.
PD DEC 1
PY 2022
VL 208
AR 118206
DI 10.1016/j.eswa.2022.118206
PG 19
WC Computer Science, Artificial Intelligence; Engineering, Electrical &
   Electronic; Operations Research & Management Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Computer Science; Engineering; Operations Research & Management Science
GA VN9PH
UT WOS:001259145700001
DA 2026-07-24
ER
PT J
AU Lev-Tov, HA
   Hermak, S
AF Lev-Tov, Hadar Avihai
   Hermak, Sarah
TI Hydration response technology dressings for low to excessively exuding
   wounds: a systematic review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE cellulose fibres; Cutimed Sorbion; exudate; gelling agent; hydration
   response technology; wound; wound care; wound dressing; wound healing
ID COST-EFFECTIVENESS; CARE; MANAGEMENT; SERIES; ULCERS
AB Objective: The aim of this systematic review was to identify and qualify the current available evidence of the wound exudate handling capabilities and the cost-effectiveness of hydration response technology (HRT). HRT combines physically modified cellulose fibres and gelling agents resulting in wound dressings that absorb and retain larger quantities of wound exudate. Method: A systematic search was conducted in MEDLINE (via PubMed and PubMed Central) according to the Preferred Reporting Items for Systematic Reviews and Meta -Analyses (PRISMA). The search was conducted using an unlimited search period. Studies or reviews that evaluated effect on wound exudate and cost-effectiveness, as well as the impact on wound healing were considered. Records focusing on wound management using HRT devices were included. Results: The literature search identified four studies and one comparative analysis, ranging from low to moderate quality, that compared HRT dressings to other interventions (carboxymethyl cellulose dressing, other superabsorbent dressings, negative pressure wound therapy). Conclusion: The analysed data supported the beneficial use of dressings with HRT for exuding wounds which was characterised by fewer dressing changes, improved periwound skin conditions and reduced costs.
C1 [Lev-Tov, Hadar Avihai; Hermak, Sarah] Univ Miami, Leonard M Miller Sch Med, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
C3 University of Miami
RP Lev-Tov, HA (通讯作者)，Univ Miami, Leonard M Miller Sch Med, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
EM hlevtov@med.miami.edu
CR Association of the Scientific Medical Societies in Germany, 2012, Local therapy of chronic wounds in patients with the risks of peripheral arterial occlusive disease, diabetes mellitus, chronic venous insufficiency
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NR 64
TC 0
Z9 1
U1 1
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2024
VL 33
IS 6
DI 10.12968/jowc.2024.0088
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA XH8Z8
UT WOS:001260896600002
PM 38843010
DA 2026-07-24
ER
PT J
AU Katoumas, K
   Mitsopoulos, G
AF Katoumas, Konstantinos
   Mitsopoulos, Georgios
TI Vol. 137 No. Vacuum-assisted closure of a tissue deficit of the
   submental area in a patient with a necrotizing soft tissue odontogenic
   infection
SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
LA English
DT Article
ID LABORATORY RISK INDICATOR; FASCIITIS; PRESSURE; SCORE; HEAD; NECK
AB Odontogenic infections can rarely progress to necrotizing soft tissue infections. Cervical necrotizing fasciitis (CNF) is a rare but fulminant infection that spreads along the fascial planes, including connective tissue, muscle, and subcutaneous fat, and is typified by necrosis of the skin and other adjacent tissues. This article aims to present the treatment of a patient with submental skin and soft tissue necrosis due to an odontogenic infection and the subsequent management of the tissue deficit with a vacuumassisted closure (VAC) system. The patient presented with extensive skin necrosis in the submental area and was immediately hospitalized, and management of the odontogenic infection was performed. When the patients' infection had been sufficiently controlled, a wound VAC device was placed in the deficit. The VAC device was removed after 12 days, and the patient was discharged. In conclusion, VAC can be used to manage tissue deficits with good aesthetic results. (Oral Surg Oral Med Oral Pathol Oral Radiol 2024;137:e119 -e124)
C1 [Katoumas, Konstantinos] Natl & Kapodistrian Univ Athens, Gen Hosp Athens Evaggelismos, Dept Oral & Maxillofacial Surg, Athens, Greece.
   [Katoumas, Konstantinos] Natl & Kapodistrian Univ Athens, Sch Dent, Athens, Greece.
   [Mitsopoulos, Georgios] 401Gen Mil Hosp Athens, Dept Oral & Maxillofacial Surg, Athens, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens
RP Katoumas, K (通讯作者)，Natl & Kapodistrian Univ Athens, Gen Hosp Athens Evaggelismos, Dept Oral & Maxillofacial Surg, Athens, Greece.; Katoumas, K (通讯作者)，Natl & Kapodistrian Univ Athens, Sch Dent, Athens, Greece.
EM k_katoumas@hotmail.com
OI Katoumas, Konstantinos/0000-0003-4264-4878
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2212-4403
EI 2212-4411
J9 OR SURG OR MED OR PA
JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol.
PD JUN
PY 2024
VL 137
IS 6
BP e119
EP e124
DI 10.1016/j.oooo.2023.10.013
EA JUN 2024
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA XS8H2
UT WOS:001263753300001
PM 38155007
DA 2026-07-24
ER
PT J
AU Hou, YF
   Griffin, L
AF Hou, Yuefeng
   Griffin, Leah
TI Comparative Effectiveness of Negative Pressure Wound Therapy with and
   Without Oxidized Regenerated Cellulose/Collagen/Silver-ORC Dressing
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE retrospective; wound healing; granulation tissue; negative pressure
   wound therapy
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; PROTEASES; STATE
AB Objective: Negative pressure wound therapy (NPWT) and oxidized regenerated cellulose (ORC)/collagen/silver-ORC (OCSO) dressings have individually demonstrated effectiveness in supporting wound healing, but few studies have examined their combined use. This retrospective data analysis compared wound outcomes following outpatient NPWT with and without OCSO dressings.Approach: A search of deidentified records from the U.S. Wound Registry resulted in 485 cases of wounds managed with NPWT with OCSO dressings. A matched cohort of patients who received NPWT without any collagen dressing (n = 485) was created using propensity scoring. For patients in the NPWT + OCSO group, OCSO was applied topically on or after the day of NPWT initiation and stopped on or before the day of NPWT termination.Results: Wounds managed with NPWT + OCSO were significantly more likely to improve and/or heal compared with wounds that received NPWT alone (p = 0.00029). The relative wound area reduction was 40% for patients receiving NPWT + OCSO, compared with 9% for patients receiving only NPWT (p = 0.0099). The median time to achieve 75-100% granulation coverage with no measurable wound depth was shorter by 8 days with NPWT + OCSO in all wound types (p = 0.00034), and by 14 days in surgical wounds (p = 0.0010), than with NPWT alone.Innovation: This is the first study examining the clinical outcomes associated with the integration of NPWT and OCSO dressings compared with the use of NPWT alone. These data support the novel practice of applying NPWT concurrently with OCSO dressings.Conclusion: This retrospective comparative analysis using real-world data demonstrated improved healing outcomes with integrated use of NPWT with OCSO dressings versus NPWT alone.
C1 [Hou, Yuefeng; Griffin, Leah] Solventum, Maplewood, MN USA.
RP Griffin, L (通讯作者)，Solventum, 12930 Interstate 10, San Antonio, TX 78249 USA.
EM lpgriffin@solventum.com
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NR 36
TC 2
Z9 2
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUN 1
PY 2025
VL 14
IS 6
BP 285
EP 294
DI 10.1089/wound.2023.0128
EA JUL 2024
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 3DA2J
UT WOS:001263794300001
PM 38666689
OA hybrid
DA 2026-07-24
ER
PT J
AU Miller-Mikolajczyk, C
   Beach, K
   Silverman, R
   Cooper, M
AF Miller-Mikolajczyk, Cynthia
   Beach, Karen
   Silverman, Ronald
   Cooper, Matthew
TI The Evolution of Commercial Negative Pressure Wound Therapy Systems over
   the Past Three Decades
SO ADVANCES IN WOUND CARE
LA English
DT Review
DE NPWT; history of NPWT; wound care; NPWT technology; NPWT innovation
ID VACUUM-ASSISTED CLOSURE; OPEN-CELL FOAM; RANDOMIZED CONTROLLED-TRIAL;
   VENOUS LEG ULCERS; INSTILLATION; BACTERIAL; MANAGEMENT; BIOBURDEN;
   RECOMMENDATIONS; COMPLICATIONS
AB Significance: Since the introduction of the first commercial negative pressure wound therapy (NPWT) system nearly three decades ago, several key technological innovations have led to the wide adoption of the therapy. This is a review of the history and innovation of commercial NPWT systems for adjunctive management of open wounds.Recent Advances: Technical modifications have broadened NPWT options to include innovative dressing interfaces, tubing configurations, power sources, capability of topical wound solution instillation or irrigation, canister versus canister-free configurations, smart technology, and disposable versus larger reusable therapy units. While these options complicate product selection, they have greatly expanded the potential to manage a wide variety of wounds in patients who previously may not have been candidates for NPWT.Critical Issues: Basic yet mandatory requirements of NPWT include delivering an accurate level of negative pressure to the wound bed, maintaining a seal, removing wound surface exudate through the dressing interface, and patient adherence to prescribed therapy. Meeting these requirements is challenging in the face of variable wound types, wound locations, exudate levels, and exudate viscosity. While there are a growing number of marketed NPWT systems, each may have different characteristics and performance. Evaluating the functionality of each system and relevant accessories is complicated, especially as additional manufacturers enter the market. Understanding the key innovations and specific challenges they are intended to solve may aid health care providers in selecting appropriate NPWT technologies for patients.Future Directions: Evolving technology, including artificial intelligence, will likely play a major role in redefining NPWT safety, simplicity, and reliability.
C1 [Miller-Mikolajczyk, Cynthia; Beach, Karen] 3M Healthcare, 9915 Fall Harvest, Minneapolis, MN 78254 USA.
   [Silverman, Ronald] Becton Dickinson & Co, Franklin, NJ USA.
   [Silverman, Ronald] Univ Maryland Med Syst, Baltimore, MD USA.
   [Cooper, Matthew] Peak Cardiovasc, Lake Elmo, MN USA.
C3 3M; Becton Dickinson; University System of Maryland; University of
   Maryland Baltimore
RP Miller-Mikolajczyk, C (通讯作者)，3M Healthcare, 9915 Fall Harvest, Minneapolis, MN 78254 USA.
EM Camiller3@mmm.com
RI ; Silverman, Ronald/A-5155-2018
OI Miller-Mikolajczyk, Cynthia/0009-0003-3162-2291; 
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NR 104
TC 10
Z9 10
U1 1
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD AUG 1
PY 2024
VL 13
IS 8
BP 375
EP 390
DI 10.1089/wound.2023.0115
EA JUL 2024
PG 16
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA A7O0L
UT WOS:001263796500001
PM 38666695
OA hybrid
DA 2026-07-24
ER
PT J
AU Pop, IC
   Ilies, RA
   Baican, C
   Strilciuc, S
   Muntean, V
   Muntean, M
AF Pop, Ioan Constantin
   Ilies, Radu Alexandru
   Baican, Corina
   Strilciuc, Stefan
   Muntean, Valentin
   Muntean, Maximilian
TI Pyoderma Gangrenosum Post-Breast Surgery: A Case Report and
   Comprehensive Review of Management Strategies
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE pyoderma gangrenosum; breast surgery; management strategies; autoimmune
   skin conditions
ID DIAGNOSIS; RECONSTRUCTION
AB Background/Objectives: Pyoderma gangrenosum (PG) is a rare, autoimmune skin condition characterized by painful, rapidly progressing ulcers, often associated with autoimmune dysregulation. Managing PG following breast surgery presents unique challenges due to its pathergy phenomenon, which complicates surgical interventions. This article outlines the case of PG in a 48-year-old female post-breast surgery and reviews management strategies through a systematic analysis of the literature. Methods: A systematic literature review from 2018 to 2023 identified 24 relevant articles on PG management post-breast surgery. The studies were analyzed to compare the efficacy and complications of conservative versus combined (conservative and surgical) treatment strategies. Results: Results indicate that while conservative management, primarily with corticosteroids, remains preferred, combined strategies, including systemic therapies, vacuum-assisted closure, and surgery, offer significant benefits in select cases. Conclusions: Our findings suggest that a personalized, multifaceted treatment plan is crucial for managing PG effectively, emphasizing the need for early detection, meticulous planning, and comprehensive care to optimize patient outcomes.
C1 [Pop, Ioan Constantin; Ilies, Radu Alexandru; Muntean, Maximilian] Prof Dr I Chiricuta Inst Oncol, Plast Surg Dept, Cluj Napoca 400015, Romania.
   [Baican, Corina] Cty Emergency Hosp, Dermatol Dept, Cluj Napoca 400006, Romania.
   [Strilciuc, Stefan] Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, Cluj Napoca 400012, Romania.
   [Strilciuc, Stefan] RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca 400337, Romania.
   [Muntean, Valentin] Humanitas Clin Hosp, Gen Surg Dept, Cluj Napoca 400012, Romania.
C3 Oncology Institute Prof. Dr. Ion Chiricuta; Iuliu Hatieganu University
   of Medicine & Pharmacy
RP Strilciuc, S (通讯作者)，Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, Cluj Napoca 400012, Romania.; Strilciuc, S (通讯作者)，RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca 400337, Romania.
EM drp.ionut@gmail.com; iliesradu.14@gmail.com; cibaican@yahoo.com;
   strilciuc.stefan@umfcluj.ro; valentin.muntean@gmail.com;
   maximilian.muntean@iocn.ro
RI Muntean, Maximilian/AGX-3926-2022; Pop, Ioan-Constantin/NOE-5241-2025;
   Strilciuc, Stefan/AAC-6253-2019
OI Muntean, Maximilian/0000-0003-0709-8779; Pop,
   Ioan-Constantin/0000-0002-7079-1106; Strilciuc,
   Stefan/0000-0001-6112-0223; Muntean, Maximilian/0000-0003-0709-8779
CR Ahn C, 2018, EXPERT REV CLIN IMMU, V14, P225, DOI 10.1080/1744666X.2018.1438269
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NR 36
TC 8
Z9 9
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2024
VL 13
IS 13
AR 3800
DI 10.3390/jcm13133800
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YD8D1
UT WOS:001266630800001
PM 38999365
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Montoya, AM
   Roncancio, GE
   Franco, L
   López, L
   Vargas, AR
   Suárez, S
   Garcés, CG
   Guzmán, M
   Vanegas, JM
AF Montoya, A. M.
   Roncancio, G. E.
   Franco, L.
   Lopez, L.
   Vargas, A. R.
   Suarez, S.
   Garces, C. G.
   Guzman, M.
   Vanegas, J. M.
TI Preventive strategies in paediatric cardiovascular surgery: impact on
   surgical site infections and beyond
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE Healthcare-associated infection prevention; Cardiovascular surgery;
   Congenital heart diseases; Microbiology
ID VENTILATOR-ASSOCIATED PNEUMONIA; CARE HOSPITALS; TIME
AB Background: Surgical management of congenital heart disease (CHD) has increased worldwide, but healthcare-associated infections (HAIs) can threaten these efforts. Aim: To analyse the incidence of HAI, the impact of preventive interventions, and microbiological profiles in a paediatric cardiovascular surgery programme.<br /> Methods: Cohort study including children aged < 12 years with CHD who underwent cardiovascular surgery between 2010 and 2021 in Medell & imath;<acute accent>n, Colombia (a middle-income setting). Data were collected from medical and laboratory records and infection control programme databases. Impact of various preventive interventions was assessed using a Poisson model. P < 0.05 was considered statistically significant. Findings: A total of 2512 surgeries were analysed. Incidence of surgical site infection (SSI) was 5.9%, followed by central line-associated bloodstream infection (CLABSI; 4.7%), catheter-associated urinary tract infection (CAUTI; 2.2%), and ventilator-associated pneumonia (VAP; 1.4%). Most of the strategies focused on preventing SSI, resulting in a reduction from 9.5% in 2010 to 3.0% in 2021 (P P 1 / 4 0.030). Antibiotic prophylaxis based on patient weight and continuous infusion had an impact on reducing SSI (RR: 0.56; 95% CI: 0.32-0.99). Vacuum-assisted closure (VAC) in clean wounds reduced 100% of infections. No significant risk reduction was observed for other HAI with the implemented interventions. Conclusion: Preventive strategies effectively reduced SSI but no other infections, emphasizing the need for targeted approaches to address a broader spectrum of HAI successfully. (c) 2024 The Authors. Published by Elsevier Ltd on behalf of The Healthcare Infection Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Montoya, A. M.; Franco, L.] Clin Cardio VID, Dept Microbiol, Medellin, Colombia.
   [Roncancio, G. E.] Clin Cardio VID, Div Infect Dis, Medellin, Colombia.
   [Lopez, L.; Vargas, A. R.; Vanegas, J. M.] Univ Pontificia Bolivariana, Sch Hlth Sci, St 1A,70-01, Medellin, Colombia.
   [Suarez, S.] Clin Cardio VID, Dept Epidemiol, Medellin, Colombia.
   [Garces, C. G.] Clin Cardio VID, Dept Cardiovasc Surg, Medellin, Colombia.
   [Vanegas, J. M.] Clin Cardio VID, Dept Paediat, Medellin, Colombia.
C3 Universidad Pontificia Bolivariana
RP Vanegas, JM (通讯作者)，Univ Pontificia Bolivariana, Sch Hlth Sci, St 1A,70-01, Medellin, Colombia.
EM johanna.vanegas@upb.edu.co
RI ; Roncancio, Gustavo/E-7793-2017
OI Vanegas, Johanna/0000-0003-0649-6660; López López,
   Lucelly/0000-0002-1534-520X; 
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NR 52
TC 2
Z9 2
U1 0
U2 4
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD AUG
PY 2024
VL 150
BP 114
EP 124
DI 10.1016/j.jhin.2024.05.001
EA JUL 2024
PG 11
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA YG4F6
UT WOS:001267315100001
PM 38740302
OA Bronze
DA 2026-07-24
ER
PT J
AU Holbert, MD
   Duff, J
   Wood, F
   Holland, AJA
   Teague, W
   Frear, C
   Crellin, D
   Phillips, N
   Storey, K
   Martin, L
   Singer, Y
   Dimanopoulos, TA
   Cuttle, L
   Vagenas, D
   McPhail, S
   Calleja, P
   De Young, A
   Kimble, RM
   Griffi, BR
AF Holbert, Maleea D.
   Duff, Jed
   Wood, Fiona
   Holland, Andrew J. A.
   Teague, Warwick
   Frear, Cody
   Crellin, Dianne
   Phillips, Natalie
   Storey, Kristen
   Martin, Lisa
   Singer, Yvonne
   Dimanopoulos, Tanesha A.
   Cuttle, Leila
   Vagenas, Dimitrios
   McPhail, Steven
   Calleja, Pauline
   De Young, Alexandra
   Kimble, Roy M.
   Griffi, Bronwyn R.
TI Barriers and co-designed strategies for the implementation of negative
   pressure wound therapy in acute pediatric burn care in Australia: A
   mixed method study
SO JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES
LA English
DT Article
DE Pediatric burn; Re-epithelialization; Negative pressure wound therapy;
   Implementation science; Implementation barriers
ID SUBATMOSPHERIC PRESSURE; PROGRESSION; EXPERIENCE; RECOMMENDATIONS;
   MANAGEMENT; DRESSINGS; PAIN; TIME
AB Purpose: Pediatric burn injuries are a global clinical issue causing significant morbidity . Early adjunctive negative pressure wound therapy improves re-epithelialization rates in children with burns, yet adoption in acute burn care is inconsistent. This investigation aimed to determine barriers to the implementation of adjunctive negative pressure wound therapy for the acute management of pediatric burns and co-design targeted implementation strategies. Methods: A sequential mixed methods design was used explore barriers to adjunctive negative pressure wound therapy implementation in acute pediatric burn care. An online questionnaire was disseminated to healthcare professionals within four major Australian pediatric hospitals, each with a dedicated burns service. Barriers were coded according to the Consolidated Framework for Implementation Research (CFIR). Semi-structured interviews with senior clinicians tailored implementation strategies to local contexts. A stakeholder consensus meeting consolidated implementation strategies and local processes. Results: Sixty-three healthcare professionals participated in the questionnaire, and semi-structured interviews involved nine senior burn clinicians. We identified eight implementation barriers across all five CFIR domains then co-designed targeted strategies to address identified barriers. Barriers included lack of available resources, limited access to knowledge and information, individual stage of change, patient needs and resources, limited knowledge and beliefs about the intervention, lack of external policies, intervention complexity, and poor implementation planning. Conclusion: Multiple contextual factors affect negative pressure wound therapy uptake in acute pediatric burn settings. Results will inform a multi-state stepped-wedge cluster randomized controlled trial. Additional resources, education, training, updated policies, and guidelines are required for successful implementation. It is anticipated that adjunctive negative pressure wound therapy, in conjunction with tailored implementation strategies, will enhance adoption and sustainability. Trial registration: Australian and New Zealand Clinical Trials Registry: ACTRN12622000166774. Registered 1 February 2022. Crown Copyright (c) 2024 Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
C1 [Holbert, Maleea D.; Storey, Kristen; Singer, Yvonne; Dimanopoulos, Tanesha A.; Griffi, Bronwyn R.] Griffith Univ, Sch Nursing & Midwifery, Nathan Campus, Brisbane, Qld 4111, Australia.
   [Holbert, Maleea D.; Frear, Cody; Crellin, Dianne; Phillips, Natalie; Storey, Kristen; Dimanopoulos, Tanesha A.; De Young, Alexandra; Kimble, Roy M.; Griffi, Bronwyn R.] Childrens Hlth Queensland Hosp & Hlth Serv, South Brisbane, Qld 4101, Australia.
   [Duff, Jed] Queensland Univ Technol, Fac Hlth, Ctr Healthcare Transformat, Brisbane, Australia.
   [Wood, Fiona; Martin, Lisa] Perth Childrens Hosp, Nedlands, WA 6009, Australia.
   [Wood, Fiona; Martin, Lisa] Univ Western Australia, Burn Injury Res Unit, Crawley, WA 6009, Australia.
   [Holland, Andrew J. A.] Childrens Hosp Westmead, Burns Unit, Westmead, NSW 2145, Australia.
   [Holland, Andrew J. A.] Univ Sydney, Fac Med & Hlth, Sydney Med Sch, Sydney, NSW 2050, Australia.
   [Teague, Warwick] Murdoch Childrens Res Inst, Surg Res, Parkville, Vic 3052, Australia.
   [Teague, Warwick; Crellin, Dianne] Royal Childrens Hosp Melbourne, Burns Serv, Parkville, Vic 3052, Australia.
   [Teague, Warwick] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia.
   [Teague, Warwick] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia.
   [Frear, Cody] Univ Queensland, Fac Med, Brisbane, QLD 4006, Australia.
   [Crellin, Dianne] Univ Melbourne, Dept Nursing, Melbourne, Vic 3010, Australia.
   [Phillips, Natalie] Univ Queensland, Child Hlth Res Ctr, South Brisbane, Qld 4101, Australia.
   [Cuttle, Leila; Vagenas, Dimitrios] Queensland Univ Technol, Fac Hlth, Sch Biomed Sci, Brisbane, Australia.
   [McPhail, Steven] Queensland Univ Technol, Australian Ctr Hlth Serv Innovat, Sch Publ Hlth & Social Work, Kelvin Grove 4059, Australia.
   [McPhail, Steven] Queensland Univ Technol, Ctr Healthcare Transformat, Sch Publ Hlth & Social Work, Kelvin Grove 4059, Australia.
   [Calleja, Pauline] James Cook Univ, Coll Healthcare Sci, Cairns 4870, Australia.
C3 Griffith University; Childrens Health Queensland Hospital & Health
   Service; Queensland University of Technology (QUT); Perth Childrens
   Hospital; University of Western Australia; NSW Health; Sydney Childrens
   Hospitals Network; The Children's Hospital at Westmead; University of
   Sydney; University of Sydney; Murdoch Children's Research Institute;
   Royal Children's Hospital Melbourne; University of Melbourne; Monash
   University; University of Queensland; University of Melbourne;
   University of Queensland; Queensland University of Technology (QUT);
   Queensland University of Technology (QUT); Queensland University of
   Technology (QUT); James Cook University
RP Holbert, MD (通讯作者)，Griffith Univ, Sch Nursing & Midwifery, Nathan Campus, Brisbane, Qld 4111, Australia.
EM m.holbert@griffith.edu.au
RI Duff, Jed/AAV-9927-2020; Phillips, Natalie/LBI-7045-2024; De Young,
   Alex/D-9093-2019; Kimble, Roy/B-4160-2011; McPhail,
   Steven/JMR-2141-2023; Wood, Fiona/F-4703-2013; Cuttle,
   Leila/C-5223-2008; Teague, Warwick/AAY-7260-2020; Griffin,
   Bronwyn/AEB-6299-2022; Calleja, Pauline/AAE-7981-2020; fiona,
   wood/F-4703-2013; Singer, Yvonne/LEN-2822-2024
OI Duff, Jed/0000-0003-1427-0303; Holbert, Maleea/0000-0002-9902-5122;
   McPhail, Steven/0000-0002-1463-662X; Wood, Fiona/0000-0001-7397-4074;
   Cuttle, Leila/0000-0002-2282-4815; Teague, Warwick/0000-0003-4747-6025;
   Martin, Lisa Joanne/0000-0001-8947-834X; Griffin,
   Bronwyn/0000-0002-6182-9125; Calleja, Pauline/0000-0001-5674-1404;
   fiona, wood/0000-0001-5427-6588; Singer, Yvonne/0000-0001-6225-5891
FU National Health and Medical Research Council (NHMRC) Partnership
   Projects PRC2 [2006970]; National Health and Medical Research Council
   (NHMRC) [2006970] Funding Source: National Health and Medical Research
   Council (NHMRC)
FX This project has been awarded funding from the National Health and
   Medical Research Council (NHMRC) Partnership Projects PRC2 Funding ID:
   2006970.
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NR 60
TC 3
Z9 6
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0882-5963
J9 J PEDIATR NURS
JI J. Pediatr. Nurs.
PD JUL-AUG
PY 2024
VL 77
BP e520
EP e530
DI 10.1016/j.pedn.2024.05.018
EA JUL 2024
PG 11
WC Nursing; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Pediatrics
GA YH3S6
UT WOS:001267564100001
PM 38762422
OA Green Published, Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Baker, BG
   Pieri, A
AF Baker, Benjamin G.
   Pieri, Andrew
TI Assessment of Patient-Reported Outcomes for Closed-Incision Negative
   Pressure Therapy with Wide-Coverage Dressings in Simple Mastectomy and
   Immediate Implant-Based Breast Reconstruction
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE closed-incision negative pressure wound therapy; mastectomy; oncology
   surgery; seroma
ID QUALITY-OF-LIFE; WOUND THERAPY; KNEE ARTHROPLASTY; CANCER; SCALE; AGE
AB Objective: A new configuration of closed-incision negative pressure therapy (ciNPT) dressings now covers the incision and a broader area of peri-incisional tissues. We have implemented these ciNPT dressings following simple mastectomy (SM) or skin-sparing mastectomy with implant-based reconstruction (IBR). This study assesses patient-reported outcomes of this new protocol. Approach: Patients underwent SM or IBR for breast cancer. ciNPT with wide-coverage dressings were placed over the entire breast, and -125 mmHg was applied for 14 days. Upon dressing removal, patients rated their experience using the Wound-Q (TM) Suction Device Scale and recorded their satisfaction on a Likert scale ranging 1-5. Results: Thirteen SM patients and 12 IBR patients were included in the study. The median age was 62 years, and SM patients were significantly older (p < 0.01). Patients rated the ciNPT device highest on items relating to its function and appearance, and lowest on noise and interference with sleep and physical activity. The overall mean score for the combined cohort was 64.8/100. The mean score for SM patients (74.8 +/- 19.9) was significantly greater than for IBR patients (53.9 +/- 9.6, p < 0.01). The mean overall patient satisfaction rating was 3.92 on a 5-point scale; 4.0 in the SM group and 3.8 in the IBR group. Innovation: This study is the first to report on the patient experience with these newly available wide-coverage ciNPT dressings. Conclusion: Overall, the dressing was well-tolerated by patients, and satisfaction was high. The positive reception of ciNPT with wide-coverage dressings supports continued use at our hospital.
C1 [Baker, Benjamin G.] Manchester Univ NHS Fdn Trust, Manchester, England.
   [Pieri, Andrew] Royal Victoria Infirm, Queen Victoria Rd, Newcastle Upon Tyne NE1 4LP, England.
C3 Manchester University NHS Foundation Trust; Newcastle University - UK
RP Pieri, A (通讯作者)，Royal Victoria Infirm, Queen Victoria Rd, Newcastle Upon Tyne NE1 4LP, England.
EM andrew.pieri@nuth.nhs.uk
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NR 22
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUN 1
PY 2025
VL 14
IS 6
BP 279
EP 284
DI 10.1089/wound.2023.0116
EA JUL 2024
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 3DA2J
UT WOS:001268871200001
PM 38695108
OA hybrid
DA 2026-07-24
ER
PT J
AU Xiao, SO
   Wang, WX
   Zhao, CY
   Ren, P
   Dong, LW
   Zhang, H
   Ma, FX
   Li, XY
   Bian, YQ
AF Xiao, Shuao
   Wang, Wenxuan
   Zhao, Congying
   Ren, Pan
   Dong, Liwei
   Zhang, Hao
   Ma, Fuxin
   Li, Xueyong
   Bian, Yongqian
TI A new mechanism in negative pressure wound therapy: interleukin-17
   alters chromatin accessibility profiling
SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
LA English
DT Article
DE chromatin accessibility; IL-17; NPWT; wound healing
ID IL-17
AB Negative pressure wound therapy (NPWT) is extensively used in clinical settings to enhance the healing of wounds. Despite its widespread use, the molecular mechanisms driving the efficacy of NPWT have not been fully elucidated. In this study, skin wound-healing models were established, with administration of NPWT. Vimentin, collagen I, and MMP9 of skin tissues were detected by immunofluorescence (IF). Gene expression analysis of skin wound tissues was performed by RNA-sequencing (RNA-seq). Protein expression was assayed by a Western blotting or IF assay, and mRNA levels were quantified by quantitative PCR. Chromatin accessibility profiles of fibroblasts following NPWT or IL-17 exposure were analyzed by ATAC-seq. In rat wound-healing models, NPWT promoted wound repair by promoting reepithelialization, extracellular matrix (ECM) synthesis, and proliferation, which mainly occurred in the early stage of wound healing. These differentially expressed genes (DEGs) in NPWT wounds versus control wounds were enriched in the IL-17 signaling pathway. IL-17 was identified as an upregulated factor following NPWT in skin wounds. Moreover, the IL-17 inhibitor secukinumab (SEC) could abolish the promoting effect of NPWT on wound healing. Importantly, chromatin accessibility profiles were altered following NPWT and IL-17 stimulation in skin fibroblasts. Our findings suggest that NPWT upregulates IL-17 to promote wound healing by altering chromatin accessibility, which is a novel mechanism for NPWT's efficacy in wound healing.
C1 [Xiao, Shuao; Zhao, Congying; Ren, Pan; Ma, Fuxin; Li, Xueyong; Bian, Yongqian] Air Force Med Univ, Affiliated Hosp 2, Dept Plast & Burn Surg, Xian, Peoples R China.
   [Wang, Wenxuan] Xiamen Univ, Xiangan Hosp, Sch Med, Dept Burn Plast & Wound Repair, Xiamen, Peoples R China.
   [Dong, Liwei] Air Force Med Univ, Affiliated Hosp 1, Dept Plast Surg, Xian, Peoples R China.
   [Zhang, Hao] Joint Logist Support Force Chinese PLA, Dept Plast & Burn Surg, Puer, Peoples R China.
C3 Air Force Medical University; Xiamen University; Air Force Medical
   University
RP Li, XY; Bian, YQ (通讯作者)，Air Force Med Univ, Affiliated Hosp 2, Dept Plast & Burn Surg, Xian, Peoples R China.
EM lixueyong641123@163.com; yongqianbian@163.com
RI Dong, Liwei/IQV-1924-2023
OI Dong, Liwei/0000-0002-7359-6664
FU Key Research and Development Projects of Shaanxi Province
   [2020ZDLSF04-13]
FX This research was supported by the Key Research and Development Projects
   of Shaanxi Province (Grant No.:2020ZDLSF04-13).
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NR 40
TC 3
Z9 3
U1 2
U2 12
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6143
EI 1522-1563
J9 AM J PHYSIOL-CELL PH
JI Am. J. Physiol.-Cell Physiol.
PD JUL 29
PY 2024
VL 327
IS 1
BP C193
EP C204
DI 10.1152/ajpcell.00650.2023
PG 12
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA YW1N3
UT WOS:001271430600001
PM 38682240
DA 2026-07-24
ER
PT J
AU Tsuchiya, M
   Kushibiki, T
   Yamashiro, T
   Mayumi, Y
   Ishihara, M
   Azuma, R
AF Tsuchiya, Masato
   Kushibiki, Toshihiro
   Yamashiro, Toshifumi
   Mayumi, Yoshine
   Ishihara, Miya
   Azuma, Ryuichi
TI Continuous negative-pressure wound therapy improves the survival rate of
   skin grafts and shortens the time required for skin graft survival
SO SKIN RESEARCH AND TECHNOLOGY
LA English
DT Article
DE cytokine; growth factor negative-pressure incubator; topical negative
   pressure; vacuum-assisted closure; vascularity
ID ENDOTHELIAL GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; FLAP DONOR SITE;
   CELLS; MANAGEMENT; MECHANISM; QUALITY; SYSTEM
AB BackgroundThe effectiveness of negative-pressure wound therapy (NPWT) in skin graft fixation has been demonstrated in several clinical studies. However, in vitro and in vivo studies on skin graft fixation with NPWT have been scarce. In this in vivo study, we aimed to determine whether NPWT fixation enhances skin graft survival and how it contributes to improving skin graft survival biologically.Materials and methodsWe harvested skin from the bilateral abdominal wall of 88 mice after anesthetizing them. Full-thickness skin grafts (FTSGs) were performed on contralateral harvest sites, and grafts were fixed using NPWT (continuous and intermittent modes), conventional compression methods, and wrapping with polyurethane foam as a control group. On days 5 and 10 of grafting, the survival rates of the FTSGs were evaluated. Immunohistopathological analysis and measurement of the expression levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF-2), and epidermal growth factor (EGF) were performed.ResultsThe survival rates of FTSG in the continuous NPWT group were significantly higher than those in the other groups. The number of capillaries in the dermis was significantly higher in the continuous NPWT group than in the other groups. In the wound bed, VEGF levels were significantly higher in both NPWT groups than in the other groups.ConclusionContinuous NPWT increases the survival rate of FTSGs and shortens the duration of skin graft survival.
C1 [Tsuchiya, Masato; Yamashiro, Toshifumi; Azuma, Ryuichi] Natl Def Med Coll, Dept Plast & Reconstruct Surg, Namiki 3-2, Tokorozawa, Saitama, Japan.
   [Kushibiki, Toshihiro; Mayumi, Yoshine; Ishihara, Miya] Natl Def Med Coll, Dept Med Engn, Tokorozawa, Saitama, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan
RP Tsuchiya, M (通讯作者)，Natl Def Med Coll, Dept Plast & Reconstruct Surg, Namiki 3-2, Tokorozawa, Saitama, Japan.
EM masatotsuchiya1984@gmail.com
RI ; Yamashiro, Toshifumi/JJE-7945-2023; Azuma, Ryuichi/AAT-1125-2021
OI Kushibiki, Toshihiro/0000-0002-1705-1467; Yamashiro,
   Toshifumi/0000-0001-7019-7740; Tsuchiya, Masato/0000-0002-6039-5169;
   Ishihara, Miya/0000-0001-6362-5014
FU Grants-in-Aid for Scientific Research [20K12725]
FX Grants-in-Aid for Scientific Research, Grant/Award Number: 20K12725
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NR 54
TC 6
Z9 6
U1 3
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0909-752X
EI 1600-0846
J9 SKIN RES TECHNOL
JI Skin Res. Technol.
PD JUL 19
PY 2024
VL 30
IS 7
AR e13865
DI 10.1111/srt.13865
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA YY8I6
UT WOS:001272135700001
PM 39031918
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Yogun, Y
   Bezirgan, U
   Ertan, MB
   Savran, MD
   Kindan, P
   Kalem, M
   Armangil, M
AF Yogun, Yener
   Bezirgan, Ugur
   Ertan, Mehmet Batu
   Savran, Merve Dursun
   Kindan, Peri
   Kalem, Mahmut
   Armangil, Mehmet
TI Comparison of Negative-Pressure Wound Therapy and Gradual Wound
   Approximation Treatments for Infected Fasciotomy Wounds
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE crush injury; earthquake; gradual wound approximation; infected
   fasciotomy wounds; negative-pressure wound therapy
ID ACUTE COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE
AB Negative-pressure wound therapy (NPWT) and gradual wound approximation (GWA) are effective and reliable methods of treating fasciotomy wounds. However, the effectiveness of these 2 methods in treating infected wounds remains unclear. The aim of our study was to compare these 2 delayed primary closure methods of treating infected fasciotomy wounds on the limbs. Patients who underwent fasciotomy surgery on the extremities after sustaining crushing injuries in the 2023 Kahramanmara & scedil;-centered earthquakes and who were referred owing to infected open wounds during follow-up were included in the study. Patients who completed the wound closure process at our clinic were divided into 2 groups: the NPWT and GWA groups. Using retrospectively collected data, the groups were compared in terms of demographic characteristics, time until wound closure, number of surgeries, skin graft requirements, and complications. Laboratory parameters were also examined. Thirteen patients, (with 21 wounds) who underwent NPWT and 14 (with 22 wounds) who underwent GWA, were examined. The average age of the NPWT group was 32.85 +/- 18.37 years, whereas that of the GWA group was 25.21 +/- 16.31 years. The number of surgeries in the NPWT and GWA groups were 5.38 +/- 2.11 and 4.23 +/- 1.27, respectively, and the difference was statistically significant (P = .040). The average wound closure times of the NPWT and GWA groups (P = .0210) (11.00 +/- 4.86 days and 8.27 +/- 2.41 days, respectively) also differed significantly. Skin grafting was performed in 5 patients in the NPWT group and 2 in the GWA group. There were no significant differences between the 2 groups in terms of skin graft requirements or complication rates. NPWT and GWA are effective and reliable methods of closing infected fasciotomy wounds. Closure of these wounds can be achieved in a shorter time and with fewer surgeries using GWA than using NPWT.
C1 [Yogun, Yener] Van Training & Res Hosp, Hand Surg Unit, TR-65300 Van, Turkiye.
   [Bezirgan, Ugur; Armangil, Mehmet] Ankara Univ, Fac Med, Orthoped & Traumatol Dept, Hand Surg Unit, Ankara, Turkiye.
   [Ertan, Mehmet Batu] Medicana Int Ankara Hosp, Orthoped & Traumatol Dept, Ankara, Turkiye.
   [Savran, Merve Dursun; Kindan, Peri; Kalem, Mahmut] Ankara Univ, Fac Med, Orthoped & Traumatol Dept, Ankara, Turkiye.
C3 Van Training & Research Hospital; Ankara University; Medicana Hospital;
   Ankara University
RP Yogun, Y (通讯作者)，Van Training & Res Hosp, Hand Surg Unit, TR-65300 Van, Turkiye.
EM yogunyener@gmail.com
RI Ertan, Mehmet Batu/AAN-4844-2021; Yoğun, Yener/ABD-8622-2021; Kindan
   Baltaci, Peri/LBA-9282-2024; armangil, mehmet/AAH-6136-2020; dursun
   savran, merve/HOC-0256-2023; kalem, mahmut/HSD-0104-2023
OI Ertan, Mehmet Batu/0000-0001-6757-9967; Yoğun,
   Yener/0000-0002-3070-5509; Kindan Baltaci, Peri/0009-0005-1302-9085;
   dursun savran, merve/0000-0002-9473-7948; 
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NR 26
TC 2
Z9 2
U1 1
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2025
VL 24
IS 1
SI SI
BP 92
EP 101
DI 10.1177/15347346241266652
EA JUL 2024
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA Y0X7J
UT WOS:001275121200001
PM 39033381
DA 2026-07-24
ER
PT J
AU Geng, YN
   Ding, N
   Zou, JF
   Zhou, HY
   Zhu, L
AF Geng, Yingnan
   Ding, Neng
   Zou, Jiefeng
   Zhou, Haiyang
   Zhu, Lie
TI Management of a complicated colon-exposed sacrococcygeal wound after
   pelvic exenteration: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE chronic wound; hard-to-heal wound; pelvic exenteration; reconstructive
   surgery; sacrococcygeal area; wound; wound care; wound closure
   techniques; wound dressing; wound healing; wound management
ID VACUUM-ASSISTED CLOSURE; FLAP; RECONSTRUCTION; RESECTION; REPAIR
AB Sacrococcygeal wound management can be challenging, especially when complicated by chronic infection, radiation and exposure of the underlying structures. Vascularised soft-tissue reconstruction is the only option when conservative wound care fails. Previous reports have mainly focused on the treatment of pressure ulcers. This report describes the case of a 54-year-old female patient with a colon-exposed, large sacrococcygeal wound after pelvic exenteration for recurrent rectal cancer. The wound was closed without dead space using two approaches: innovative vacuum sealing drainage (VSD); and gluteus maximus myocutaneous flap repair. Timely debridement, accurate assessment of intervention, appropriate design of composite tissue flap, and conscientious wound care contributed to complete wound healing within two months.
C1 [Geng, Yingnan; Ding, Neng; Zou, Jiefeng; Zhu, Lie] Naval Med Univ, Affiliated Hosp 2, Dept Burns & Plast Surg, Shanghai, Peoples R China.
   [Zhou, Haiyang] Naval Med Univ, Affiliated Hosp 2, Dept Colorectal Surg, Shanghai, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Zhu, L (通讯作者)，Naval Med Univ, Affiliated Hosp 2, Dept Burns & Plast Surg, Shanghai, Peoples R China.; Zhou, HY (通讯作者)，Naval Med Univ, Affiliated Hosp 2, Dept Colorectal Surg, Shanghai, Peoples R China.
EM haiyang1985_1@aliyun.com; zhulie19811@smmu.edu.cn
OI Zhu, Lie/0000-0002-4947-9767
FU Naval Medical University [2022QN073]; University of Shanghai for Science
   and Technology Joint Projects [2020-RZ04]; Innovative Clinical Research
   Program of Shanghai Changzheng Hospital [2020YLCYJ-Y16]
FX This work was supported by the Naval Medical University and the
   University of Shanghai for Science and Technology Joint Projects
   (2020-RZ04) , the Innovative Clinical Research Program of Shanghai
   Changzheng Hospital (2020YLCYJ-Y16) , and the academic project of Naval
   Medical University (2022QN073). The authors have no conflicts of
   interest to declare.
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NR 15
TC 1
Z9 1
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2024
VL 33
IS 7
BP 515
EP 518
DI 10.12968/jowc.2022.0116
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ZO6G2
UT WOS:001276272300009
PM 38967340
DA 2026-07-24
ER
PT J
AU Yohannes, A
   Knievel, J
   Lange, J
   Dormann, AJ
   Hügle, U
   Eisenberger, CF
   Heiss, MM
AF Yohannes, Alexander
   Knievel, Judith
   Lange, Jonas
   Dormann, Arno J.
   Huegle, Ulrich
   Eisenberger, Claus F.
   Heiss, Markus M.
TI VacStent as an Innovative Approach in the Treatment of Anastomotic
   Insufficiencies and Leakages in the Gastrointestinal Tract-Review and
   Outlook
SO LIFE-BASEL
LA English
DT Review
DE VacStent; anastomotic insufficiency; endoscopic vacuum therapy;
   gastrointestinal leakage; covered stent; esosponge
AB Anastomotic insufficiencies are severe complications of abdominal surgery, often leading to prolonged hospitalization, serious tissue inflammation, and even sepsis, along with the need for recurrent surgery. Current non-surgical treatments such as self-expanding metal stents (SEMSs) and endoscopic vacuum therapy (EVT) have limitations, including stent migration or perforation. This review evaluates the effectiveness of the VacStent GITM (M & ouml;ller Medical GmbH, Fulda, Germany), a novel medical device combining SEMS and negative-pressure wound therapy in treating gastrointestinal leaks. Data were gathered from four prospective studies and compared with existing treatments. Studies on the VacStent GITM application demonstrate technical success and competitive closure rates in upper gastrointestinal leaks, with minimal complications reported. Comparative analyses with SEMS and EVT reveal promising and most importantly equally good outcomes while maintaining the possibility for sustained enteral nutrition and reducing the risk of stent migration. The VacStent GITM presents a promising alternative to current non-surgical treatments. Ongoing research aims to validate its efficacy in lower gastrointestinal leaks and comprehensively establish its role in leak management. Further investigation is necessary to confirm these findings and optimize treatment protocols. Future usages of the VacStent GITM in colonic anastomotic insufficiencies promise an effective approach and might be able to lower the rates of necessary implementations of a stoma.
C1 [Yohannes, Alexander; Dormann, Arno J.; Huegle, Ulrich] Ctr Interdisciplinary Visceral Med, Dept Gastroenterol Gastrointestinal Oncol Gastroin, Cologne Holweide & Merheim Med Ctr, D-51109 Cologne, Germany.
   [Yohannes, Alexander; Knievel, Judith; Lange, Jonas; Eisenberger, Claus F.; Heiss, Markus M.] Witten Herdecke Univ, Ctr Interdisciplinary Visceral Med, Cologne Merheim Med Ctr, Dept Abdominal Tumour Transplant & Vasc Surg, D-51109 Cologne, Germany.
RP Heiss, MM (通讯作者)，Witten Herdecke Univ, Ctr Interdisciplinary Visceral Med, Cologne Merheim Med Ctr, Dept Abdominal Tumour Transplant & Vasc Surg, D-51109 Cologne, Germany.
EM yohannesa@kliniken-koeln.de; knievelj@kliniken-koeln.de;
   langej@kliniken-koeln.de; dormanna@kliniken-koeln.de;
   huegleu@kliniken-koeln.de; eisenbergercf@kliniken-koeln.de;
   heissm@kliniken-koeln.de
OI Yohannes, Alexander/0009-0001-4562-9924; Knievel,
   Judith/0000-0002-6213-590X
CR [Anonymous], 2023, Instructions for Use VacStent GI TM Esophagus.
   Bachmann J, 2022, WORLD J SURG ONCOL, V20, DOI 10.1186/s12957-022-02551-z
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   Chon SH, 2021, VISC MED, V37, P403, DOI 10.1159/000512320
   de Groot EM, 2023, DIS ESOPHAGUS, V36, DOI 10.1093/dote/doac094
   Lange J, 2023, FRONT SURG, V10, DOI 10.3389/fsurg.2023.1182094
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   Lange J, 2023, FRONT SURG, V10, DOI 10.3389/fsurg.2023.1133083
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NR 16
TC 3
Z9 4
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JUL
PY 2024
VL 14
IS 7
AR 821
DI 10.3390/life14070821
PG 10
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA ZR5E8
UT WOS:001277026800001
PM 39063574
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lin, B
   Zhang, HJ
   Sun, SJ
   Lin, CQ
   Chi, YL
AF Lin, Bao
   Zhang, Hongjian
   Sun, Shijie
   Lin, Changqing
   Chi, Yuanlong
TI Application and Prognostic Analysis of Vacuum Sealing Drainage in the
   Incision Infection in Patients With Stage II-III Colorectal Cancer
SO AMERICAN SURGEON
LA English
DT Article
DE colorectal neoplasms; vacuum sealing drainage; surgical site infection;
   healing; prognosis
ID SURGICAL SITE INFECTION; PRESSURE WOUND THERAPY; EFFICACY; IMPACT
AB Introduction This study aims to explore the application value of vacuum sealing drainage (VSD) technology in the treatment of incision infection dehiscence after surgery in patients with stage II-III colorectal cancer and analyze its impact on prognosis. Methods This retrospective study included patients who experienced incision infection dehiscence after surgery for colorectal cancer between February 2014 and August 2019. Clinical and pathological data, short-term outcomes, and long-term outcomes were compared between the traditional group and the VSD group. Results A total of 97 patients were included in this study. There was no significant difference in clinical and pathological data between the traditional group and the VSD group (P > 0.05). The VSD group had fewer dressing changes, lower pain scores during dressing changes, and better granulation tissue growth grading than the traditional group, with statistical significance (P < 0.05). The VSD group started adjuvant chemotherapy earlier and had a higher proportion of >= 4 cycles of chemotherapy. The three-year overall survival rate in the VSD group was better than the traditional group, but the difference was not statistically significant (P > 0.05). Conclusion The application of VSD technology can promote granulation tissue growth, accelerate incision healing, and facilitate patients to complete subsequent adjuvant chemotherapy. However, further verification of its long-term impact on prognosis requires longer-term follow-up results.
C1 [Lin, Bao; Zhang, Hongjian; Sun, Shijie; Lin, Changqing; Chi, Yuanlong] Fujian Med Univ, Affiliated Sanming Hosp 1, Dept Gastrointestinal Surg, 15 Dongxin 1st Rd, Sanming 365000, Fujian Province, Peoples R China.
C3 Fujian Medical University
RP Chi, YL (通讯作者)，Fujian Med Univ, Affiliated Sanming Hosp 1, Dept Gastrointestinal Surg, 15 Dongxin 1st Rd, Sanming 365000, Fujian Province, Peoples R China.
EM smlancet@163.com
OI chi, yuanlong/0000-0003-2072-0497; Sun, Shijie/0009-0009-0953-8150; Lin,
   Bao/0009-0004-4793-9354
CR Badia JM, 2017, J HOSP INFECT, V96, P1, DOI 10.1016/j.jhin.2017.03.004
   Cai LY, 2022, INJURY, V53, P777, DOI 10.1016/j.injury.2021.10.018
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NR 26
TC 0
Z9 0
U1 1
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD DEC
PY 2024
VL 90
IS 12
BP 3253
EP 3261
DI 10.1177/00031348241265133
EA JUL 2024
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J7Q0F
UT WOS:001278255500001
PM 39030681
DA 2026-07-24
ER
PT J
AU Kamarajah, SK
   Markar, SR
AF Kamarajah, Sivesh K.
   Markar, Sheraz R.
TI Navigating complexities and considerations for suspected anastomotic
   leakage in the upper gastrointestinal tract: A state of the art review
SO BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
LA English
DT Review
DE Anastomotic leak; Oesophagectomy; Gastrectomy; Surgical treatment; Risk
   factors
ID VACUUM-ASSISTED CLOSURE; PERIOPERATIVE CHEMOTHERAPY; SURGICAL-TREATMENT;
   OPEN-LABEL; ESOPHAGECTOMY; MANAGEMENT; MULTICENTER; DIAGNOSIS; IMPACT;
   CANCER
AB This state-of-the-art review explores the intricacies of anastomotic leaks following oesophagectomy and gastrectomy, crucial surgeries for globally increasing esophageal and gastric cancers. Despite advancements, anastomotic leaks occur in up to 30 % and 10 % of oesophagectomy and gastrectomy cases, respectively, leading to prolonged hospital stays, substantial impact upon short- and long-term health-related quality of life and greater mortality. Recognising factors contributing to leaks, including patient characteristics and surgical techniques, are vital for preoperative risk stratification. Diagnosis is challenging, involving clinical signs, biochemical markers, and various imaging modalities. Management strategies range from non-invasive approaches, including antibiotic therapy and nutritional support, to endoscopic interventions such as stent placement and emerging vacuum-assisted closure devices, and surgical interventions, necessitating timely recognition and tailored interventions. A step-up approach, beginning non-invasively and progressing based on treatment success, is more commonly advocated. This comprehensive review highlights the absence of standardised treatment algorithms, emphasizing the importance of individualised patient-specific management.
C1 [Kamarajah, Sivesh K.] Univ Birmingham, Inst Appl Hlth Res, Dept Global Hlth & Surg, Birmingham, England.
   [Markar, Sheraz R.] Univ Oxford, Nuffield Dept Surg, Surg Intervent Trials Unit, Oxford, England.
C3 University of Birmingham; University of Oxford
RP Markar, SR (通讯作者)，Univ Oxford, Nuffield Dept Surg, Surg Intervent Trials Unit, Oxford, England.
EM sheraz.markar@nds.ox.ac.uk
RI Kamarajah, Sivesh K/AAE-8159-2021
OI Kamarajah, Sivesh K/0000-0002-2748-0011; Markar,
   Sheraz/0000-0002-4040-5681
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   Tang H, 2012, J GASTROINTEST SURG, V16, P722, DOI 10.1007/s11605-011-1788-z
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   van Heijl M, 2010, BRIT J SURG, V97, P726, DOI 10.1002/bjs.6971
   van Rossum PSN, 2017, DIS ESOPHAGUS, V30, DOI 10.1111/dote.12472
   van Workum F, 2017, ANN THORAC SURG, V103, P267, DOI 10.1016/j.athoracsur.2016.07.010
   Wang SM, 2024, LANCET GASTROENTEROL, V9, P229, DOI 10.1016/S2468-1253(23)00366-7
   Wiggins T, 2015, SURG ONCOL, V24, P181, DOI 10.1016/j.suronc.2015.06.011
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NR 54
TC 8
Z9 8
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1521-6918
EI 1532-1916
J9 BEST PRACT RES CL GA
JI Best Pract. Res. Clin. Gastroenterol.
PD JUN
PY 2024
VL 70
AR 101916
DI 10.1016/j.bpg.2024.101916
EA JUL 2024
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA ZY6G8
UT WOS:001278879000001
PM 39053974
OA Green Submitted
DA 2026-07-24
ER
PT J
AU van de Voort, JC
   Brekelmans, W
   Ritchie, ED
   Leijnen, M
AF van de Voort, Jan C.
   Brekelmans, Wouter
   Ritchie, Ewan D.
   Leijnen, Michiel
TI Preventing Surgical Site Infections in Geriatric Ankle Fracture Surgery
   with Closed-Incision Vacuum Therapy: A Pilot Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE ankle fracture; closed-incision vacuum therapy; geriatric;
   negative-pressure wound therapy; surgery; surgical site infection; wound
   infection
ID RISK-FACTORS; OPERATIVE TREATMENT; INTERNAL-FIXATION; COMPLICATIONS;
   IMPACT; DRESSINGS; RATES; LIFE; HIP
AB BackgroundAnkle fractures are among the most common fractures in older adult patients that need surgical treatment. The risk of surgical site infections (SSIs) after ankle fracture surgery ranges between 0.5% and 30%; SSI incidence is higher among older adults. Further, SSIs have significant consequences for subjective functional outcomes and create a need for prolonged intravenous antibiotic therapy and wound care. Accordingly, it is critical to determine risk factors for and establish optimal postoperative wound care to prevent SSIs.ObjectiveThe aim of the pilot study was to examine the feasibility of closed-incision vacuum therapy (CIVT) to reduce rates of SSI in older adults.MethodsThe authors performed a pilot study of a CIVT system in a population of 10 older adult patients after ankle fracture surgery.ResultsNine patients experienced uncomplicated wound healing of the lateral incision. One patient (10%) developed an SSI after premature removal of the vacuum system because of technical failure. Six weeks postoperation, overall satisfaction with the CIVT was high; none of the participants complained of incapacitating discomfort or disruptive limitations in postsurgical recovery.ConclusionsThe authors conclude that CIVT is a feasible, safe, and generally well-tolerated therapy to prevent SSIs in postoperative wound healing after open reduction and internal fixation in older adult patients after ankle fracture.
C1 [van de Voort, Jan C.] Alrijne Hosp, Leiderdorp, Netherlands.
   [Brekelmans, Wouter] Alrijne Wound Ctr, Leiderdorp, Netherlands.
RP van de Voort, JC (通讯作者)，Alrijne Hosp, Leiderdorp, Netherlands.
EM jcvandevoort@alrijne.nl; wbrekelmans@alrijne.nl; edritchie@alrijne.nl;
   mleijnen@alrijne.nl
CR Aigner R, 2017, FOOT ANKLE INT, V38, P41, DOI 10.1177/1071100716667315
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NR 34
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD APR
PY 2024
VL 37
IS 4
BP 6
EP 6
DI 10.1097/ASW.0000000000000124
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA A1O2Z
UT WOS:001280290800012
PM 38506586
DA 2026-07-24
ER
PT J
AU Zhang, WJ
   Wu, Y
   Pan, C
   Zhang, XY
   Yan, H
   Zhang, L
AF Zhang, Wenjing
   Wu, Yang
   Pan, Cheng
   Zhang, Xiangyun
   Yan, Hong
   Zhang, Li
TI Ruptured giant omphalocele with congenital short small intestine: a case
   report
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE omphalocele; congenital short small intestine; vacuum-sealing drainage;
   nutrition; perioperative management
ID SHORT-BOWEL SYNDROME; MANAGEMENT; GASTROSCHISIS; CHILDREN
AB We herein present a case of a ruptured giant omphalocele with congenital short small intestine. Vacuum-sealing drainage and carboxymethylcellulose silver dressing promoted wound healing after repair, avoided abdominal compartment syndrome, and reduced the risks of multiple procedures. We review the perioperative management of omphaloceles in congenital short small intestines.
C1 [Zhang, Wenjing; Zhang, Li] Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China.
   [Zhang, Wenjing; Zhang, Li] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Peoples R China.
   [Wu, Yang] Sichuan Univ, West China Hosp, Dept Pediat Surg, Chengdu, Peoples R China.
   [Pan, Cheng; Zhang, Xiangyun; Yan, Hong] Sichuan Univ, West China Univ Hosp 2, Dept Plast Aesthet Reparat & Reconstruct Surg, Chengdu, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Sichuan
   University
RP Zhang, L (通讯作者)，Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China.; Zhang, L (通讯作者)，Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Peoples R China.
EM zhanglihk@126.com
FU Science and Technology Bureau of Sichuan Province [2022YFS0044]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by the grants from the Science and Technology Bureau of
   Sichuan Province (2022YFS0044).
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NR 34
TC 0
Z9 0
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 18
PY 2024
VL 11
AR 1421033
DI 10.3389/fnut.2024.1421033
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA A3D1Y
UT WOS:001281359800001
PM 39091686
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Salciccia, A
   de Pouyade, G
   Caudron, I
   Ponthier, J
   Serteyn, D
   Sandersen, C
   Deleuze, S
   Grulke, S
AF Salciccia, Alexandra
   de la Rebiere de Pouyade, Geoffroy
   Caudron, Isabelle
   Ponthier, Jerome
   Serteyn, Didier
   Sandersen, Charlotte
   Deleuze, Stefan
   Grulke, Sigrid
TI Surgical Closure of Equine Abdomen, Prevention, and Management of
   Incisional Complications
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EXPLORATORY CELIOTOMY; WOUND THERAPY; HORSES;
   SURGERY
AB Although rarely fatal, complications of ventral midline laparotomy incision in equine patients increase hospitalization cost and duration and may jeopardize return to athletic function. Therefore, many techniques have been developed to reduce their occurrence and expedite their resolution when they occur. Our technique of celiotomy incision closure includes the use of tension sutures (vertical U mattress) of polyglactin 910 on the linea alba , which is then apposed by polyglactin 910 interrupted sutures or a simple continuous pattern suture with a stop midway before routine closure of the superficial layers. The celiotomy incision is protected by an elastic bandage during the immediate postoperative period. This technique has been associated with favorable results: 5.3% confirmed incisional infections after a single celiotomy and 26.7% after repeat celiotomy. The overall incisional complication (serous/sanguineous discharge, hematoma, infection, hernia formation, and complete wound breakdown) occurrence was 9.5% and 33.3% after single and repeat laparotomy, respectively. In cases considered more susceptible to infection (early relaparotomy or laparotomy incisions longer than 30 cm), negative pressure therapy was found easy to apply on closed incisions. No detrimental effects were observed. However, the potential prophylactic benefit of this therapy needs to be confirmed in a larger group. In infected laparotomy wounds requiring drainage, the use of negative pressure therapy seemed to have a positive effect on the formation of granulation tissue. However, there was no control group to allow statistical confirmation. Finally, one case of complete breakdown of the laparotomy incision was managed by stainless steel retention sutures, the application of negative pressure therapy, and a hernia belt. At re-evaluation 15 months post -surgery, several small hernias were detected, but the horse had returned to his previous level of sports performance and had not shown any episode of colic.
C1 [Salciccia, Alexandra; de la Rebiere de Pouyade, Geoffroy; Caudron, Isabelle; Serteyn, Didier; Grulke, Sigrid] Univ Liege, Vet Teaching Hosp, Equine Surg, Liege, Belgium.
   [Ponthier, Jerome; Deleuze, Stefan] Univ Liege, Vet Teaching Hosp, Equine Reprod, Liege, Belgium.
   [Sandersen, Charlotte] Univ Liege, Vet Teaching Hosp, Anesthesia, Liege, Belgium.
C3 University of Liege; University of Liege; University of Liege
RP Salciccia, A (通讯作者)，Univ Liege, Vet Teaching Hosp, Equine Surg, Liege, Belgium.
EM alexandra.salciccia@uliege.be
RI ; Grulke, Sigrid/NTQ-5996-2025
OI deleuze, stefan/0000-0003-3076-5779; 
FX answering the long-term follow-up questionnaire and allowing taking
   pictures of the horse. Finally, the authors thank M. Laurent Leinartz
   for his help in editing the pictures.
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NR 33
TC 5
Z9 5
U1 1
U2 4
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD MAY
PY 2024
IS 207
AR e65546
DI 10.3791/65546
PG 25
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA A3O4U
UT WOS:001281657200011
PM 38801261
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Lei, FR
   Shen, XF
   Zhang, C
   Li, XQ
   Zhuang, H
   Sang, HF
AF Lei, Feng-Rui
   Shen, Xiao-Fei
   Zhang, Chuang
   Li, Xin-Qing
   Zhuang, Hao
   Sang, Hong-Fei
TI Clinical efficacy of endovascular revascularization combined with
   vacuum-assisted closure for the treatment of diabetic foot
SO WORLD JOURNAL OF DIABETES
LA English
DT Article
DE Diabetic foot; Revascularization; Vacuum-assisted closure; Balloon
   angioplasty; Wound repair
ID TISSUE LOSS; ANGIOPLASTY; ISCHEMIA; BYPASS; IMPACT
AB BACKGROUND The diabetic foot is a common cause of disability and death, and comorbid foot infections usually lead to prolonged hospitalization, high healthcare costs, and a significant increase in amputation rates. And most diabetic foot trauma is complicated by lower extremity arteriopathy, which becomes an independent risk factor for major amputation in diabetic foot patients. AIM To establish the efficacy and safety of endovascular revascularization (ER) combined with vacuum-assisted closure (VAC) for the treatment of diabetic foot. METHODS Clinical data were collected from 40 patients with diabetic foot admitted to the Second Affiliated Hospital of Soochow University from April 2018 to April 2022. Diabetic foot lesions were graded according to Wagner's classification, and blood flow to the lower extremity was evaluated using the ankle-brachial index test and computerized tomography angiography of the lower extremity arteries. Continuous subcutaneous insulin infusion pumps were used to achieve glycemic control. Lower limb revascularization was facilitated by percutaneous tran-sluminal balloon angioplasty (BA) or stenting. Wounds were cleaned by nibbling debridement. Wound granulation tissue growth was induced by VAC, and wound repair was performed by skin grafting or skin flap transplantation. RESULTS Of the 35 cases treated with lower limb revascularization, 34 were successful with a revascularization success rate of 97%. Of these, 6 cases underwent stenting after BA of the superficial femoral artery, and 1 received popliteal artery stent implantation. In the 25 cases treated with infrapopliteal artery revascularization, 39 arteries were reconstructed, 7 of which were treated by drug-coated BA and the remaining 32 with plain old BA. VAC was performed in 32 wounds. Twenty-four cases of skin grafting and 2 cases of skin flap transplantation were performed. Two patients underwent major amputations, whereas 17 had minor amputations, accounting for a success limb salvage rate of 95%. CONCLUSION ER in combination with VAC is a safe and effective treatment for diabetic foot that can significantly improve limb salvage rates. The use of VAC after ER simplifies and facilitates wound repair.
C1 [Lei, Feng-Rui; Shen, Xiao-Fei; Zhang, Chuang; Li, Xin-Qing; Zhuang, Hao; Sang, Hong-Fei] Soochow Univ, Affiliated Hosp 2, Dept Vasc Surg, 1055 Sanxiang Rd, Suzhou 215004, Jiangsu, Peoples R China.
C3 Soochow University - China
RP Sang, HF (通讯作者)，Soochow Univ, Affiliated Hosp 2, Dept Vasc Surg, 1055 Sanxiang Rd, Suzhou 215004, Jiangsu, Peoples R China.
EM sanghongfei@163.com
RI shen, xiaofei/LRT-1082-2024; Li, Xinqing/QJW-7508-2026
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NR 12
TC 4
Z9 4
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JUL 15
PY 2024
VL 15
IS 7
DI 10.4239/wjd.v15.i7.1499
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA A4B1H
UT WOS:001281989200010
PM 39099828
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, WB
   Zheng, JH
AF Li, Wenbo
   Zheng, Jianghong
TI Negative Pressure Wound Therapy for Chronic Wounds
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; chronic wounds
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; FRACTURES; NPWT; INSTILLATION;
   MECHANISM; INFECTION; SURGERY; TRAUMA; FLAP
AB Chronic wounds, including those caused by venous and arterial insufficiency, diabetic complications, and pressure-induced ulcers, pose significant treatment challenges. Negative pressure wound therapy has been increasingly used for managing these wounds. This treatment aims to promote wound healing, prepare the wound bed for further surgical intervention, minimize the risk of infection, and potentially shorten the time to wound healing. Considering variances in techniques applied in different regions globally, there is an emerging need to comprehensively evaluate the effectiveness of negative pressure wound therapy on chronic wounds. Unfortunately, detailed descriptions of the techniques applied to achieve negative pressure are often lacking in existing literature abstracts, posing challenges for direct comparisons. This review aims to analyze the application of negative pressure wound therapy in the treatment of chronic wounds, summarize its advantages and disadvantages, and further explore the potential value and future research direction of negative pressure wound therapy in the repair of chronic wounds.
C1 [Li, Wenbo; Zheng, Jianghong] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Plast Surg Dept, Shanghai 200233, Peoples R China.
C3 Shanghai Jiao Tong University
RP Zheng, JH (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Plast Surg Dept, Shanghai 200233, Peoples R China.
EM 2214254069@qq.com
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NR 55
TC 19
Z9 19
U1 7
U2 53
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD AUG
PY 2024
VL 93
IS 2S
SU 1
BP S19
EP S26
DI 10.1097/SAP.0000000000003891
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A7R6W
UT WOS:001284476700001
PM 38896874
DA 2026-07-24
ER
PT J
AU Ge, YN
   Saad, M
   Nemani, S
   Shi, YD
   Lineaweaver, WC
   Yang, YW
AF Ge, Yining
   Saad, Mariam
   Nemani, Sriya
   Shi, Yuedong
   Lineaweaver, William C.
   Yang, Yanwen
TI Diagnosis and Treatment of Skin Lesions in Renal Transplant Recipients
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE renal transplant; cutaneous infection; skin cancer; PTLD; plastic and
   reconstructive surgery; BCC, basal cell carcinoma; EBV, Epstein-Barr
   virus; ENKL, extranodal NK/T-cell lymphoma; FTSG, full thickness skin
   graft; mTOR, mammalian target of rapamycin; NGS, next-generation
   sequencing; NK, natural killer; PTLD, posttransplant lymphoproliferative
   disorder; SCC, squamous cell carcinoma; VSD, vacuum sealing drainage
ID SQUAMOUS-CELL CARCINOMA; AESTHETIC SURGERY; LYMPHOMA; CANCER;
   IMMUNOSUPPRESSION; MALIGNANCY; THERAPY; PATIENT; RISK
AB BackgroundImmunosuppressive therapy is essential for to prevent graft rejection in renal transplant patients; however, it is associated with elevating the risk of several pathologies in these patients particularly infectious and neoplastic conditions. In this study, we explore the diagnosis and treatment of skin lesions in renal transplant patients.MethodsA retrospective chart review of 12 renal transplant recipients referred to plastic and reconstructive surgery with skin lesions from 2000 to 2020 was performed.ResultsThe mean age of the 12 patients was 49.6 years. Time to plastic surgery after renal transplantation ranged between 1 and 16 years. Nine cases of basal cell carcinoma, 2 cases of squamous cell carcinoma, and 1 case of skin and soft tissue infection of the lower extremity and cutaneous extranodal NK/T-cell lymphoma, nasal type was observed. Flaps, skin grafts, and artificial dermis grafts constitute the main reconstructive methods. There were no postoperative infections or wound dehiscence.ConclusionsCutaneous infections and skin malignancy account for most of the skin lesions developing after renal transplantation. Posttransplant lymphoproliferative disorder warrants equal attention and should not be disregarded. Early diagnosis and treatment significantly improve prognosis as patients with longer duration of transplant were found to have more aggressive tumors. Plastic and reconstructive surgery offers a safe therapeutic method of treatment in these cases.
C1 [Ge, Yining; Shi, Yuedong; Yang, Yanwen] Fudan Univ, Zhongshan Hosp, Dept Plast & Reconstruct Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
   [Saad, Mariam; Nemani, Sriya; Lineaweaver, William C.] Vanderbilt Univ Sch Med, Dept Plast Surg, Nashville, TN USA.
C3 Fudan University; Vanderbilt University
RP Ge, YN (通讯作者)，Fudan Univ, Zhongshan Hosp, Dept Plast & Reconstruct Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
EM ge.yining@zs-hospital.sh.cn; mariam.saad.1@vumc.org;
   sriya.nemani@vumc.org; shi.yuedong@zs-hospital.sh.cn;
   william.c.lineaweaver@vumc.org; yang.yanwen@zs-hospital.sh.cn
RI yang, yanwen/LRC-5259-2024
OI Nemani, Sriya/0009-0003-7286-1993
CR Acosta AM, 2016, PATHOLOGY, V48, P380, DOI 10.1016/j.pathol.2016.03.011
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   Lempers VJC, 2015, CURR OPIN PHARMACOL, V24, P38, DOI 10.1016/j.coph.2015.07.002
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NR 30
TC 1
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD AUG
PY 2024
VL 93
IS 2S
SU 1
BP S51
EP S54
DI 10.1097/SAP.0000000000003930
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A7R6W
UT WOS:001284476700015
PM 39101849
OA hybrid
DA 2026-07-24
ER
PT J
AU Costa, ML
   Achten, J
   Knight, R
   Campolier, M
   Massa, MS
AF Costa, M. L.
   Achten, J.
   Knight, R.
   Campolier, M.
   Massa, M. S.
TI Five- year outcomes for patients sustaining severe fractures of the
   lower limb from the Wound Healing in Surgery for Trauma (WHIST) trial
SO BONE & JOINT JOURNAL
LA English
DT Article
ID SURGICAL SITE INFECTION; MAJOR TRAUMA; NEUROPATHIC CHARACTERISTICS;
   DISPLACED FRACTURE; CHRONIC PAIN; THERAPY; PREVALENCE; DISABILITY;
   EUROQOL; ADULTS
AB Aims The aims of this study were to report the outcomes of patients with a complex fracture of the lower limb in the five years after they took part in the Wound Healing in Surgery for Trauma (WHIST) trial. Methods The WHIST trial compared negative pressure wound therapy (NPWT) dressings with standard dressings applied at the end of the first operation for patients undergoing internal fixation of a complex fracture of the lower limb. Complex fractures included periarticular fractures and open fractures when the wound could be closed primarily at the end of the first debridement. A total of 1,548 patients aged >= 16 years completed the initial follow- up, six months after injury. In this study we report the pre- planned analysis of outcome data up to five years. Patients reported their Disability Rating Index (DRI) (0 to 100, in which 100 = total disability), and health- related quality of life, chronic pain scores and neuropathic pain scores annually, using a self- reported questionnaire. Complications, including further surgery related to the fracture, were also recorded. Results A total of 1,015 of the original patients (66%) provided at least one set of outcome data during the five years of follow- up. There was no evidence of a difference in patient- reported disability between the two groups at five years (NPWT group mean DRI 30.0 (SD 26.5), standard dressing group mean DRI 31.5 (SD 28.8), adjusted difference-0.86 (95% CI-4.14 to 2.40; p = 0.609). There was also no evidence of a difference in the complication rates at this time. Conclusion We found no evidence of a difference in disability ratings between NPWT compared with standard wound dressings in the five years following the surgical treatment of a complex fracture of the lower limb. Patients in both groups reported high levels of persistent disability and reduced quality of life, with little evidence of improvement during this time.
C1 [Costa, M. L.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskeleta, Orthopaed Trauma Surg, Oxford, England.
   [Achten, J.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskeleta, Oxford Trauma & Emergency Care, Oxford, England.
   [Knight, R.] Univ Oxford, Oxford, England.
   [Campolier, M.; Massa, M. S.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskeleta, Oxford, England.
C3 University of Oxford; University of Oxford; University of Oxford;
   University of Oxford
RP Costa, ML (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskeleta, Orthopaed Trauma Surg, Oxford, England.
EM matthew.costa@ndorms.ox
RI ; Achten, Juul/KUD-8515-2024
OI Knight, Ruth/0000-0001-6810-2845; Massa, Sofia/0000-0003-3205-6706;
   Achten, Juul/0000-0002-8857-5743; Campolier, Marta/0000-0002-7168-2534;
   Costa, Matthew/0000-0003-3644-1388
FU UK National Institute for Health and Care Research Health Technology
   Assessment (HTA) Programme [14/199/14]; National Institute for Health
   and Care Research (NIHR) Oxford Biomedical Research Centre
FX The authors disclose receipt of the following financial or material
   support for the research, authorship, and/or publication of this
   article: this project was funded by the UK National Institute for Health
   and Care Research Health Technology Assessment (HTA) Programme
   (14/199/14) and was supported by the National Institute for Health and
   Care Research (NIHR) Oxford Biomedical Research Centre. The funder has
   not been involved in the design and conduct of the study; collection,
   management, analysis, and interpretation of the data; preparation,
   review, or approval of the manuscript nor in the decision to submit the
   manuscript for publication. The views expressed are those of the authors
   and not necessarily those of the NHS, the NIHR or the Department of
   Health. Smith & Nephew provided incisional NPWT dressings (PICO Single
   Use Negative Pressure Wound Therapy System) to recruiting centres for
   the purposes of the trial, but had no part in the design, conduct, or
   reporting of the study.
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NR 17
TC 2
Z9 3
U1 1
U2 2
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD AUG
PY 2024
VL 106B
IS 8
BP 858
EP 864
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA A8M3V
UT WOS:001285021200013
PM 39084646
DA 2026-07-24
ER
PT J
AU Seretis, K
   Bounas, N
AF Seretis, Konstantinos
   Bounas, Nikolaos
TI Securing skin grafts: A network meta-analysis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Skin grafting; Graft; Meta-analysis; Fixation; Wound healing; Review
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; FIBRIN SEALANT;
   CLINICAL-TRIAL; BURN WOUNDS; LEG ULCERS; THICKNESS; INTEGRATION;
   EFFICACY; MECHANISM
AB Background: Skin grafting is one of the most common procedures in plastic surgery. However, there are no defined guidelines for optimal fixation. The aim of this network metaanalysis (NMA) was to consolidate existing evidence by comparing various graft securing methods and determining the most effective approach for clinical practice. Methods: An NMA was conducted using a predetermined protocol after searching several electronic databases from inception to October 2023 for studies examining skin grafting fixation outcomes in adults. Results: A total of 27 studies were included in the analysis involving 1937 patients. Negative pressure wound therapy (NPWT) was the only method to significantly improve graft take percentages in comparison with the other modalities, whereas tie-over bolster (TOB) provided the worst results in take rates when examined as events. Fibrin glue (FIB) and TOB reduced hematoma and seroma rates when data were investigated in conjunction. Conclusions: NPWT appears to be the most effective for skin graft adherence as opposed to traditional techniques. Its cost-effectiveness remains unclear, as NPWT is a relatively costly intervention compared with other methods. FIB and TOB are methods that can serve as a method of reducing hematoma and seroma rates in patients at high risk of bleeding. Level of evidence: I. (c) 2024 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Seretis, Konstantinos; Bounas, Nikolaos] Univ Ioannina, Med Sch, Dept Plast Surg, Ioannina, Greece.
   [Seretis, Konstantinos] Leoforos St Niarchou, Ioannina 45500, Greece.
C3 University of Ioannina
RP Seretis, K (通讯作者)，Leoforos St Niarchou, Ioannina 45500, Greece.
EM drseretis@uoi.gr
RI Seretis, Konstantinos/GPX-2431-2022; Bounas, Nikolaos/HQY-5525-2023
OI Seretis, Konstantinos/0000-0002-1844-1264; Bounas,
   Nikolaos/0000-0003-1243-5346
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NR 62
TC 6
Z9 6
U1 0
U2 5
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD SEP
PY 2024
VL 96
BP 146
EP 157
DI 10.1016/j.bjps.2024.07.005
EA JUL 2024
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A9M5K
UT WOS:001285708600001
PM 39089211
DA 2026-07-24
ER
PT J
AU Satteson, ES
   Crantford, JC
   Wood, J
   David, LR
AF Satteson, Ellen S.
   Crantford, John Clayton
   Wood, Jeyhan
   David, Lisa R.
TI Outcomes of Vacuum-Assisted Therapy in the Treatment of Head and Neck
   Wounds
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Head and neck reconstruction; head and neck wounds; negative pressure
   wound therapy; subatmospheric pressure therapy; vacuum-assisted closure
AB Introduction: Head and neck wounds can present a reconstructive challenge for the plastic surgeon. Whether from skin cancer, trauma, or burns, there are many different treatment modalities used to dress and manage complex head and neck wounds. Vacuum-assisted closure (VAC) therapy has been used on wounds of nearly every aspect of the body but not routinely in the head and neck area. This study was conducted to demonstrate our results using the VAC in the treatment of complex head and neck wounds.
   Methods: This is an IRB-approved, retrospective review of 69 patients with 73 head and neck wounds that were managed using the VAC between 1999 and 2008. The wound mechanism, location, and size, length of VAC therapy, patient comorbidities, use of radiation, complications, and ultimate outcome were assessed. In this patient population, the VAC was utilized because the standard reconstructive ladder was not a good option or had previously failed.
   Results: Sixty-nine patients with complex head and neck wounds were treated with the wound VAC. The mean age of the patients was 66 years, with a range of 5-96 years. Males outnumbered females in this study nearly 2:1. Eighty-six percent of patients had wounds secondary to cancer, 8% secondary to trauma, 3% secondary to infection, and 3% secondary to burns. The VAC was used as a dressing over skin grafts in 50%, over Integra in 21%, and over open debrided wounds in 29%. Wounds healed without complication in 44% of the skin grafts, 67% of Integra-covered wounds, and 71% of debrided wounds. Minor complications included failure of complete graft take, failure of granulation tissue formation in open debrided wounds, infection, and hematoma formation under skin grafts. Major complications included positive cancer margins requiring reexcision and death secondary to pulmonary embolism, sepsis, and metastatic cancer. Most complications resolved with dressing changes, repeat grafting, or the administration of antibiotics.
   Conclusions: Our results demonstrate that the wound VAC provides a reliable, effective, and durable dressing for a multitude of complex head and neck wounds. Additionally, it is a valuable tool when traditional surgical procedures are not a viable option.
C1 [Satteson, Ellen S.; Crantford, John Clayton; David, Lisa R.] Wake Forest Univ, Dept Plast & Reconstruct Surg, Sch Med, Med Ctr Blvd, Winston Salem, NC 27157 USA.
   [Wood, Jeyhan] Univ N Carolina, Sch Med, Div Plast & Reconstruct Surg, Chapel Hill, NC USA.
C3 Wake Forest University; University of North Carolina; University of
   North Carolina Chapel Hill; University of North Carolina School of
   Medicine
RP David, LR (通讯作者)，Wake Forest Univ, Dept Plast & Reconstruct Surg, Sch Med, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM ldavid@wakehealth.edu
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NR 19
TC 19
Z9 25
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD OCT
PY 2015
VL 26
IS 7
BP E599
EP E602
DI 10.1097/SCS.0000000000002047
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA VO0TC
UT WOS:001289276100004
PM 26468835
DA 2026-07-24
ER
PT J
AU Lorenzo, LR
   Salto, EA
   Cañas, EG
   González, ZM
   Espi, MS
   Gaibar, AG
AF Lorenzo, Laura Rodriguez
   Salto, Eduardo Arrea
   Canas, Elena Gonzalez
   Gonzalez, Zoilo Madrazo
   Espi, Marta Santos
   Gaibar, Antonio Gimenez
TI Incisional Negative Pressure Wound Therapy After Revascularisation
   Surgery in Patients with Peripheral Arterial Disease: A Randomised Trial
   (PICO-Vasc Study)
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE Groin surgical wound; Incisional negative pressure wound therapy;
   Surgical site infection; Surgical site occurrence
ID SURGICAL SITE INFECTION; PREVENTION; GROIN; COMPLICATIONS; MANAGEMENT;
   MALNUTRITION; METAANALYSIS; GUIDELINE; ISCHEMIA
AB Objective: This study assessed the potential benefits of using incisional negative pressure wound therapy (iNPWT) for patients undergoing revascularisation due to peripheral arterial disease. Methods: A prospective randomised controlled trial was conducted to compare the inguinal application of iNPWT vs. standard surgical dressings. Patients were enrolled from February 2021 to November 2022. A total of 133 groin incisions were randomised (66 intervention group, 67 control group). The randomisation sequence was carried out by permuted blocks and allocation assigned by opening opaque envelopes once the revascularisation procedure had finished. Wound healing and complication rates were assessed at postoperative days 5, 14, and 30. Primary and secondary endpoints were: 30 day post-operative surgical site infection (SSI) and surgical site occurrence (SSO) rates, defined as a surgical wound complication other than a SSI. Post-operative SSI was defined according to the US Centers for Disease Control and Prevention criteria. SSO included: wound dehiscence, seroma or lymphocele, haematoma, and lymphorrhagia. The study was registered at ClinicalTrials.gov database (NCT04840576) and reported according to the CONSORT guidelines. Results: iNPWT did not modify the 30 day inguinal SSI and SSO rates (16.7% vs. 20.9% and 37.9% vs. 44.8%; p = .53, relative risk [RR] 0.999, 95% confidence interval [CI] 0.52 - 1.88 and p = .42, RR 1.29, 95% CI 0.89 - 1.86, respectively). It reduced the early SSO rate (19.7% vs. 35.8%; p = .044, RR 1.45, 95% CI 1.047 - 2.013) and postoperative seroma rate (4.6% vs. 19.4%; p = .014, RR 1.73, 95% CI 1.296 - 2.397). Conclusion: There were no differences in SSI and SSO rates, although statistically significant reductions in early SSO rates and seroma were found in the intervention group.
C1 [Lorenzo, Laura Rodriguez; Salto, Eduardo Arrea; Canas, Elena Gonzalez; Gonzalez, Zoilo Madrazo; Gaibar, Antonio Gimenez] Corp Sanitaria Parc Tauli, Vasc Surg Dept, Barcelona, Spain.
   [Gonzalez, Zoilo Madrazo] Bellvitge Univ Hosp, Gen Surg Dept, Barcelona, Spain.
C3 Autonomous University of Barcelona; Parc Tauli Hospital Universitari;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona
RP Lorenzo, LR (通讯作者)，Hosp Sabadell, Corp Sanitaria Parc Tauli, One Parc Tauli, Barcelona 08208, Spain.
EM lmrodriguez@tauli.cat
RI ; Arrea Salto, Eduardo/JOZ-6047-2023; Madrazo, Zoilo/ADE-9129-2022
OI GIMENEZ-GAIBAR, ANTONIO/0000-0002-1837-4989; GONZALEZ,
   ELENA/0000-0002-7509-7404; Arrea Salto, Eduardo/0000-0002-6804-1146;
   ROIGUEZ LORENZO, LAURA/0000-0003-2977-4627; Santos Espí,
   Marta/0000-0003-1801-2491; 
FX Funding This study was promoted and initiated by the principal
   investigator and did not receive any funding or sponsorship.
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NR 53
TC 8
Z9 9
U1 0
U2 6
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD AUG
PY 2024
VL 68
IS 2
BP 238
EP 244
DI 10.1016/j.ejvs.2024.04.031
EA AUG 2024
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA C5D1J
UT WOS:001289559300001
PM 38677468
OA Bronze
DA 2026-07-24
ER
PT J
AU Cuthbert, C
   Zaghloul, T
   Bhatia, S
   Mothi, SS
   Davis, E
   Heavens, HG
   Bishop, MW
   Talbot, LJ
   Neel, MD
   Abdelhafeez, AH
AF Cuthbert, Chance
   Zaghloul, Tarek
   Bhatia, Shalini
   Mothi, Suraj Sarvode
   Davis, Erma
   Heavens, Heather G.
   Bishop, Michael W.
   Talbot, Lindsay J.
   Neel, Michael D.
   Abdelhafeez, Abdelhafeez H.
TI Use of Vacuum-Assisted Closure to Reduce the Likelihood of Wound
   Complications After Limb-Sparing Resection of Pediatric Primary Bone
   Sarcomas of the Femur
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Bone sarcoma; Osteosarcoma; Ewing sarcoma; Limb sparing; Wound; VAC
ID SOFT-TISSUE SARCOMA; PREOPERATIVE RADIOTHERAPY; THERAPY; SURGERY;
   CHEMOTHERAPY; PREDICTORS; TRIAL
AB Background: Limb-sparing surgery is the standard of care for primary bone tumors. However, such procedures are associated with high rates of wound complications, specifically in lower-extremity surgeries. Therefore, identifying and implementing interventions to minimize the likelihood of wound complications after limb-sparing resection of the lower extremity is crucial. Methods: Patients who underwent limb-sparing osteosarcoma or Ewing sarcoma resection during a 7year period at a single institution were retrospectively reviewed. Data were collected on 39 patients who underwent limb-sparing resection of the femur. Patient demographics, tumor characteristics, and perioperative and postoperative data were extracted and analyzed. Patients who underwent resection before April 2017 received conventional postoperative incision dressings. Starting in April 2017, patients received vacuum-assisted closure (VAC) with the 3 MTM Prevena VAC system after surgical closure. Eighteen patients received conventional postoperative incision dressing, and 21 received incisional wound VAC. A wound complication was defined as any Clavien-Dindo classification greater than 0 within a 28-day postoperative period. Results: Patients who received postoperative incisional wound VAC had lower rates of wound complications than those who received conventional incision dressings (14% vs. 50%; p = 0.035). Additionally, patients in whom wound complications developed had a longer average hospital stay than those without wound complications (5 days vs. 4 days; p = 0.029). Conclusions: Wound complications prolong the hospital stay and can delay adjuvant chemotherapy for bone tumors. The use of postoperative incisional wound VAC is associated with less likelihood of wound complications and should be considered in any high-risk surgical closure. Level of Evidence: Level III Treatment Study. (c) 2024 Elsevier Inc. All rights reserved.
C1 [Cuthbert, Chance; Zaghloul, Tarek; Talbot, Lindsay J.; Neel, Michael D.; Abdelhafeez, Abdelhafeez H.] St Jude Childrens Res Hosp, Dept Surg, MS 133,262 Danny Thomas Pl, Memphis, TN 38105 USA.
   [Zaghloul, Tarek] Cairo Univ, Natl Canc Inst, Dept Surg Oncol, Giza, Egypt.
   [Bhatia, Shalini; Mothi, Suraj Sarvode] St Jude Childrens Res Hosp, Dept Biostat, 262 Danny Thomas Pl, Memphis, TN 38105 USA.
   [Davis, Erma; Heavens, Heather G.] St Jude Childrens Res Hosp, Ctr Adv Practice, 262 Danny Thomas Pl, Memphis, TN 38105 USA.
   [Bishop, Michael W.] St Jude Childrens Res Hosp, Dept Oncol, 262 Danny Thomas Pl, Memphis, TN 38105 USA.
   [Talbot, Lindsay J.; Abdelhafeez, Abdelhafeez H.] Univ Tennessee, Hlth Sci Ctr, Dept Surg, 800 Madison Ave, Memphis, TN 38163 USA.
C3 St Jude Children's Research Hospital; Egyptian Knowledge Bank (EKB);
   National Cancer Institute - Egypt; Cairo University; St Jude Children's
   Research Hospital; St Jude Children's Research Hospital; St Jude
   Children's Research Hospital; University of Tennessee System; University
   of Tennessee Health Science Center
RP Abdelhafeez, AH (通讯作者)，St Jude Childrens Res Hosp, Dept Surg, MS 133,262 Danny Thomas Pl, Memphis, TN 38105 USA.
EM Hafeez.abdelhafeez@stjude.org
RI ; Sarvode Mothi, Suraj/JYQ-5641-2024
OI Cuthbert, Chance/0009-0004-4704-0795; Abdelhafeez,
   Abdelhafeez/0000-0002-7671-3037; Zaghloul, Tarek/0000-0001-7387-1112; 
FU American Lebanese Syrian Associated Charities (ALSAC)
FX <BOLD>Financial sources </BOLD> This work was supported by the American
   Lebanese Syrian Associated Charities (ALSAC) .
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NR 32
TC 4
Z9 6
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD SEP
PY 2024
VL 59
IS 9
BP 1735
EP 1739
DI 10.1016/j.jpedsurg.2024.02.028
EA AUG 2024
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA C7S7B
UT WOS:001291338100001
PM 38548494
DA 2026-07-24
ER
PT J
AU Currie, RV
   Durand, CJ
   Bond, J
AF Currie, Rachel V.
   Durand, Ciaran J.
   Bond, Jeremy
TI Reducing the incidence of problematic seroma formation and skin necrosis
   post-lymphadenectomy: Triple action of topical tranexamic acid, negative
   pressure wound therapy, and prolonged drainage
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Lymphadenectomy; Lymph node clearance; Lymph node surgery; Inguinal
   dissection; Axillary dissection; Complications
ID LYMPH-NODE DISSECTION; RANDOMIZED CLINICAL-TRIAL; INGUINAL
   LYMPHADENECTOMY; DOUBLE-BLIND; BLOOD-LOSS; SURGERY; MANAGEMENT
AB Background: Axillary and inguinal lymph node dissections are commonly associated with complications that often require additional interventions. Methods: Patients who underwent axillary or inguinal lymphadenectomy via standard procedures were compared to an intervention cohort of patients who underwent axillary or inguinal lymphadenectomy with the use of topical tranexamic acid (TXA) to the wound cavity, a PICO (Smith&Nephew UK) closed-incision negative pressure dressing, and discharged early with a drain in-situ. Results: Seventy-six patients in the control group (mean age 65.8 years, mean BMI 28.4 kg/m(2)) underwent open lymphadenectomy without topical TXA and a simple dressing. Seventy-eight patients were included in the intervention group (mean age 67.1 years, mean BMI 28.5 kg/m(2)). Patients in the intervention group had an inpatient stay of mean 5.6 days fewer than those in the control group (CI 3.09-5.31; p < .0001), an estimated saving to the healthcare trust of  pound 3046.40 (US$3723.61) per patient in "bed days." They had longer drain duration (mean 15 days vs. 8.3 days); however, they had a statistically significant lower risk of seroma formation requiring drainage (6.4% vs. 21%; p = .009), and skin necrosis (0% vs. 6.6%; p = .027). They also had a lower risk of infection (17% vs. 29%), wound dehiscence (15% vs. 25%), and readmission (7.7% vs. 14%), although they were not statistically significant. Patients in the control group were more likely to receive antibiotics as inpatients (51% vs. 7.7%; p < .00001) and on discharge (24% vs. 5%; p < .0011) than those in the intervention group. Conclusions: Topical TXA, PICO dressing, and early discharge with a drain following lymphadenectomy results in a reduced rate of complications. (c) 2024 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Currie, Rachel V.; Durand, Ciaran J.; Bond, Jeremy] Ulster Hosp, Reg Dept Maxillofacial & Plast Surg, Upper Newtownards Rd, Belfast BT16 1RH, North Ireland.
RP Currie, RV (通讯作者)，Ulster Hosp, Reg Dept Maxillofacial & Plast Surg, Upper Newtownards Rd, Belfast BT16 1RH, North Ireland.
EM rcurrie26@qub.ac.uk
FX Funding Many thanks to Mr. Richard Fallis, Specialist Librarian for
   Medicine, Dentistry & Healthcare Sciences at the Healthcare Library of
   Northern Ireland, for his assistance in locating relevant previous
   publications for discussion.
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NR 36
TC 0
Z9 1
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JUL
PY 2024
VL 94
BP 54
EP 61
DI 10.1016/j.bjps.2024.04.065
EA MAY 2024
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA C9I1L
UT WOS:001292416900001
PM 38759512
DA 2026-07-24
ER
PT J
AU Lumsden, EJ
   Kimble, RM
   Ware, RS
   Griffin, B
AF Lumsden, Emma J.
   Kimble, Roy M.
   Ware, Robert S.
   Griffin, Bronwyn
TI Tissue Pressure Changes and Implications on Dressing Selection when
   utilising Negative Pressure Wound Therapy on an Ex Vivo Porcine Model
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy; Tissue pressure change; Dressing
   selection; Porcine abbreviations; NPWT; ICP; Intracranial pressure
   transducer
ID VACUUM-ASSISTED CLOSURE; CONTRACTION; FILLERS
AB Negative Pressure Wound Therapy (NPWT) is broadly used in surgical wound management and more recently burn care; however, the tissue pressure changes and best dressing application technique remains unknown. This study was done to help understand the tissue pressure changes beneath negative pressure when varying the delivered pressures, dressing thickness and distribution of dressings. This study was done in 2021 at a quaternary paediatric burns hospital. Utilising a cadaveric porcine model, an intracranial pressure monitor and transducer were used to assess pressure. The transducer was placed on the epidermis or inserted under ultrasound guidance via cannulation to the dermis, subcutaneous or muscular layer. Mepitel (TM), ACTICOAT (TM), varying layers of Kerlix (TM) (10, 20 or 30 layers) and NPWT were then applied either circumferentially or non-circumferentially. Each set of results is indicative of the intracranial pressure probe reading when NPWT was delivered at -40, -60, -80, -100 and -120 mmHg. The median and interquartile pressure recordings were epidermis: -42 (-42.5 - -41), -60.5 (-62.5 - -60), -80.5 (-82 - -80), - 99 (-99 - -98)mmHg (p < 0.001); dermis: 1 (0 - 2), 2 (1 - 3.5), 3 (2 - 5.5), 4 (3 - 7), 5.5 (4 - 7.5)mmHg (p < 0.001) (the increase in pressure was less when circumferential dressings (p < 0.001) or more layers of Kerlix were applied (p < 0.001)); subcutis: 1.5 (-4.5-1), -2.5 (-7.5 - 1.5), -3.5 (-11 - 1.5), -5 (-14 - 1.5) and -6 (-16 - 2)mmHg (p = 006) (the decrease in pressure was less with increased layers of Kerlix (0.047) and muscular: 0 (-0.5 - 0), 0 (-1 - 0.5), 0 (-1 - 1), 0 0 (-1 - 1), 00 (-1.5 - 1)mmHg (p = 0.55). These data suggest negative pressure paradoxically exerts a positive pressure on the dermis. Circumferential and multi-layer dressings reduce this positive pressure. This knowledge has impacted our burn negative pressure wound therapy dressing selection. The limitation of this study is the cadaveric model, a live model is suggested for future studies.
C1 [Lumsden, Emma J.; Kimble, Roy M.; Griffin, Bronwyn] Griffith Univ, Fac Hlth, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
   [Lumsden, Emma J.; Kimble, Roy M.] Queensland Childrens Hosp, Dept Paediat Surg Urol Burns & Trauma, Stanley St, South Brisbane, Qld 4101, Australia.
   [Lumsden, Emma J.; Kimble, Roy M.; Griffin, Bronwyn] Ctr Childrens Hlth Res, 62 Graham St, South Brisbane, Qld 4101, Australia.
   [Ware, Robert S.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
C3 Griffith University; Childrens Health Queensland Hospital & Health
   Service; Queensland Childrens Hospital; Griffith University
RP Lumsden, EJ (通讯作者)，62 Graham St, South Brisbane, Qld 4101, Australia.
EM emma.lumsden@health.qld.gov.au
RI Ware, Robert/B-2024-2014; Griffin, Bronwyn/AEB-6299-2022; Kimble,
   Roy/B-4160-2011
OI Ware, Robert/0000-0002-6129-6736; Griffin, Bronwyn/0000-0002-6182-9125; 
CR Almulhim A.M., 2022, Evaluation of postmortem changes
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   Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
   Argenta L, 1993, JOINT M WOUND HEAL S
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NR 20
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD JUN
PY 2024
VL 50
IS 5
BP 1241
EP 1246
DI 10.1016/j.burns.2024.01.023
EA MAY 2024
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA C9I6K
UT WOS:001292429800001
PM 38378389
OA gold
DA 2026-07-24
ER
PT J
AU Huang, JH
   Li, J
   Li, RC
   Wu, X
   Lei, YX
   Zhou, ZG
AF Huang, Jihui
   Li, Jun
   Li, Ruichen
   Wu, Xing
   Lei, Yuanxue
   Zhou, Zhiguo
TI Infectious wrist arthritis complicating acute carpal tunnel syndrome in
   a child: A CARE-compliant case report
SO MEDICINE
LA English
DT Article
DE acute carpal tunnel syndrome; case report; children; infectious wrist
   arthritis; vacuum sealing drainage
ID SEPTIC ARTHRITIS
AB Introduction:The objective of this case report is to provide clinical evidence that acute infectious wrist arthritis in children can lead to the rare condition of acute carpal tunnel syndrome (ACTS). This article discusses in detail the characteristics of infectious wrist arthritis complicating ACTS in children in terms of etiology, pathogenic bacteria, treatment modalities, and sequelae to improve the understanding of this disease.Patient concerns:A 10-year-old male child presented with a 15-day history of swelling and pain in the left forearm, wrist, and hand.Diagnoses:Left-sided infected wrist arthritis complicating ACTS.Interventions:The child received emergency surgery and anti-infective treatment combined with regular rehabilitation.Outcomes:During the treatment period, the child's wrist pain and swelling gradually improved, and wrist movement was restored compared with the preoperative period. At 6-month follow-up, the activities of the metacarpophalangeal joints of the left hand were close to normal, and the flexion of the left wrist joint was slightly limited.Conclusion:In infectious wrist arthritis in children, ACTS is a serious complication that requires aggressive surgical carpal tunnel release to avoid median nerve injury in addition to anti-infective therapy.
C1 [Huang, Jihui; Li, Ruichen] Wuhan Univ Sci & Technol, Med Coll, Wuhan, Peoples R China.
   [Li, Jun; Wu, Xing; Lei, Yuanxue; Zhou, Zhiguo] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Tongji Med Coll, Wuhan 430019, Peoples R China.
C3 Wuhan University of Science & Technology; Huazhong University of Science
   & Technology
RP Zhou, ZG (通讯作者)，Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Tongji Med Coll, Wuhan 430019, Peoples R China.
EM 18327696030@163.com; lrc6760@163.com; lrc6760@163.com; 948571927@qq.com;
   leiyuanxue@zgwhfe.com; mlpnk999@163.com
RI Li, RuiChen/JVZ-4755-2024
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NR 15
TC 1
Z9 1
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG 16
PY 2024
VL 103
IS 33
AR e39276
DI 10.1097/MD.0000000000039276
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C9Q1N
UT WOS:001292625200035
PM 39151517
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Waheed, MT
   Malik, I
   Ituarte, PHG
   Han, ER
   Lwin, T
   Paz, IB
   Woo, Y
   Melstrom, L
   Raoof, M
AF Waheed, Muhammad Talha
   Malik, Ibrahim
   Ituarte, Philip H. G.
   Han, Ernest
   Lwin, Thinzar
   Paz, Isaac B.
   Woo, Yanghee
   Melstrom, Laleh
   Raoof, Mustafa
TI Association of negative pressure wound therapy and surgical site
   infections in patients undergoing cytoreductive surgery: An entropy
   balanced analysis
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE cytoreductive surgery; negative-pressure wound therapy; NPWT; surgical
   site infection; vacuum assisted closure
ID AMERICAN-COLLEGE; PREDICTION MODEL; RISK-FACTORS; IMPACT; GUIDELINES;
   COHORT; DRAIN; COST
AB Background and Objectives: Surgical site infections (SSIs) after cytoreductive surgery (CRS) +/- hyperthermic intraperitoneal chemotherapy (HIPEC) are a major cause of potentially avoidable morbidity. We explored the association of negative pressure wound therapy (NPWT) with SSI in patients undergoing CRS/HIPEC. Methods: Retrospective analysis of consecutive patients undergoing CRS/HIPEC for non-gynecologic cancers. Exposure was the receipt of NPWT versus traditional skin closure. Primary outcome was SSI within 90 days of surgery. We performed multivariable logistic regression (before and after entropy balancing) to evaluate the association of exposure with outcomes. Results: A total of 251 patients were included, of which 43 (17%) received NPWT and 26 (10.4%) developed SSIs. Baseline demographics and clinicopathologic characteristics were similar between the two groups with some exceptions: Patients who received NPWT had a higher Peritoneal Carcinomatosis Index (median 19 vs. 11, p = 0.002) and operative time (10 vs. 8.2 h, p = 0.003) but were less likely to undergo HIPEC (84% vs. 95%, p < 0.05). After entropy balancing, on multivariable logistic regression, NPWT was not associated with 90-day SSI (odds ratio = 0.90; 95% confidence interval = 0.21-3.80; p = 0.89). Conclusion: NPWT was not associated with a reduction in SSIs. These findings prompt a reevaluation of the routine use of NPWT in CRS/HIPEC.
C1 [Waheed, Muhammad Talha; Ituarte, Philip H. G.; Han, Ernest; Paz, Isaac B.; Woo, Yanghee; Melstrom, Laleh; Raoof, Mustafa] City Hope Natl Med Ctr, Dept Surg, Duarte, CA USA.
   [Malik, Ibrahim; Lwin, Thinzar] Wayne State Univ, Sch Med, Detroit, MI USA.
C3 City of Hope; Wayne State University
RP Raoof, M (通讯作者)，City Hope Natl Med Ctr, Dept Surg, Div Surg Oncol, 1500 E Duarte Rd, Duarte, CA 91010 USA.
EM mraoof@coh.org
RI Ituarte, Philip/ABG-5332-2021
OI Waheed, Muhammad Talha/0000-0002-0679-4396; Melstrom,
   Laleh/0000-0001-6279-7981
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NR 44
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD OCT
PY 2024
VL 130
IS 5
BP 1139
EP 1150
DI 10.1002/jso.27828
EA AUG 2024
PG 12
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA P9Y7X
UT WOS:001293196500001
PM 39155656
OA Bronze
DA 2026-07-24
ER
PT J
AU Yu, YL
   Xia, JQ
   Jiang, Q
AF Yu, Yalu
   Xia, Jiaqi
   Jiang, Qin
TI Causes of Mediastinitis and Its Surgical Treatment
SO HEART SURGERY FORUM
LA English
DT Review
DE mediastinitis; risk factors; sternal fixation devices
ID STERNAL WOUND-INFECTION; POST-STERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   RISK-FACTORS; POSTOPERATIVE MEDIASTINITIS; STAPHYLOCOCCUS-AUREUS;
   CLINICAL-FEATURES; PLATE FIXATION; CLOSURE; TRANSFUSION
AB Mediastinitis remains a potentially fatal complication of cardiac surgery. This study reviews the risk factors for mediastinitis after cardiac surgery, and discusses current treatment and prevention of this complication. This review explores three major independent risk factors for mediastinitis including individual patient factors, surgical procedures and microbiology. The perioperative period is influenced by the utilization of the internal mammary artery in conjunction with coronary artery bypass grafting, sternal fixation, vacuum-assisted closure, and negative pressure wound therapy. Staphylococcus aureus and Staphylococcus epidermidis are frequently encountered microorganisms. Additionally, aerobic gram-negative microorganisms and other infrequent microorganisms are also exhibiting a rising trend. Since sternal fixation devices effectively enhance sternal stability, alleviate wound pain, and decrease the occurrence of postoperative mediastinitis, they have been specifically incorporated into certain therapeutic and prophylactic approaches for addressing this complication. Despite the heightened awareness regarding mediastinitis, the large proportion of individuals at risk underscores the crucial need for rigorous monitoring of potential risk factors, posing a significant challenge to the implementation of effective therapeutic and preventative strategies.
C1 [Yu, Yalu; Xia, Jiaqi; Jiang, Qin] Univ Elect Sci & Technol China, Sch Med, Chengdu 610054, Sichuan, Peoples R China.
   [Jiang, Qin] Univ Elect Sci & Technol, Sichuan Prov Peoples Hosp, Affiliated Hosp, Dept Cardiac Surg, Chengdu 610072, Sichuan, Peoples R China.
   [Jiang, Qin] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ultrasound Cardiac Electrophysiol & Biomech Key La, Chengdu 610072, Sichuan, Peoples R China.
C3 University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital; University of Electronic Science &
   Technology of China; Sichuan Provincial People's Hospital; University of
   Electronic Science & Technology of China
RP Jiang, Q (通讯作者)，Univ Elect Sci & Technol, Sichuan Prov Peoples Hosp, Affiliated Hosp, Dept Cardiac Surg, Chengdu 610072, Sichuan, Peoples R China.; Jiang, Q (通讯作者)，Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ultrasound Cardiac Electrophysiol & Biomech Key La, Chengdu 610072, Sichuan, Peoples R China.
EM jq349@163.com
FU Huanhua Talent for Discipline Backbone of Sichuan Provincial People's
   Hospital [SY2022017]; Science Fund for Distinguished Young Scholars of
   Sichuan Province [2021JDJQ0041]; National Natural Science and Technology
   Foundation of China [81800274]
FX This work was supported by Huanhua Talent for Discipline Backbone of
   Sichuan Provincial People's Hospital [SY2022017] , Science Fund for
   Distinguished Young Scholars of Sichuan Province [2021JDJQ0041] ,
   National Natural Science and Technology Foundation of China [81800274] .
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NR 84
TC 0
Z9 0
U1 0
U2 6
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PY 2024
VL 27
IS 7
BP E838
EP E846
DI 10.59958/hsf.7617
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA D2Y3B
UT WOS:001294888300016
OA gold
DA 2026-07-24
ER
PT J
AU Brascia, D
   Mangiameli, G
   Marulli, G
AF Brascia, Debora
   Mangiameli, Giuseppe
   Marulli, Giuseppe
TI Complex chest wall reconstruction after failure: a literature review
SO JOURNAL OF THORACIC DISEASE
LA English
DT Review
DE Chest wall reconstruction; prosthesis; biological mesh; failure; chest
   wall tumors
ID VACUUM-ASSISTED CLOSURE; STERNAL RECONSTRUCTION; TITANIUM PLATES;
   RESECTION; INFECTION; TUMORS; BONE; STABILIZATION; OMENTUM; DEFECT
AB Background and Objective: Primary and secondary chest wall tumors (bone, breast, and soft tissue), congenital defects, and chest wall osteoradionecrosis often require extensive full-thickness local excisions to guarantee safe oncological margins (in cases of tumors) and complex reconstruction to provide stabilization and good biomechanical results avoiding postoperative respiratory failure. Thus, a personalized approach is required when dealing with chest wall defects, and reconstruction is planned. This review summarizes failed chest wall reconstruction procedures, identifies causes of failure, and highlights principles for complex chest wall reconstruction post-failure. Methods: We performed a narrative review of the literature on PubMed, Scopus, ScienceDirect, and Google Scholar, including all the relevant studies published from 1970. Key Content and Findings: The available experiences in literature are only anecdotic and no current guidelines or rules exist on this topic, also given to its rarity. Proper pre-surgical planning and a multidisciplinary team (MDT) discussion are crucial for complex cases such as infections and radiationinduced chest ulcers after previous surgical treatment. Procedures should eventually include thoracic wall debridement, necrotic tissue excision, pulse-jet lavage, prosthesis removal, and vacuum assisted closure (VAC) therapy as a bridge for chest wall re-reconstruction. Sternotomy wounds require wire and prosthesis removal, and the use of meshes or bone allografts. This review aims to summarize experiences and highlight surgical and oncologic principles for complex chest wall reconstruction after failure. Conclusions: This review summarizes literature experiences to identify common key points for chest wall reconstruction after failure and to give some advice to surgeons managing this rare, challenging surgery.
C1 [Brascia, Debora] Bari Univ Hosp, Thorac Surg Unit, Bari, Italy.
   [Brascia, Debora] Univ Bologna, Alma Mater Studiorum, Bologna, Italy.
   [Brascia, Debora; Mangiameli, Giuseppe; Marulli, Giuseppe] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20072 Pieve Emanuele, Milan, Italy.
   [Mangiameli, Giuseppe; Marulli, Giuseppe] IRCCS Humanitas Res Hosp, Via Manzoni 56, I-20089 Rozzano, Milan, Italy.
C3 Universita degli Studi di Bari Aldo Moro; University of Bologna;
   Humanitas University
RP Marulli, G (通讯作者)，Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20072 Pieve Emanuele, Milan, Italy.; Marulli, G (通讯作者)，IRCCS Humanitas Res Hosp, Via Manzoni 56, I-20089 Rozzano, Milan, Italy.
EM giuseppe.marulli@hunimed.eu
RI Brascia, Debora/HKN-8837-2023; Mangiameli, Giuseppe/AAX-1916-2020;
   MARULLI, GIUSEPPE/LOS-8884-2024
OI Brascia, Debora/0000-0003-0860-1647; Mangiameli,
   Giuseppe/0000-0002-8394-2719; MARULLI, GIUSEPPE/0000-0001-6570-615X
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NR 55
TC 3
Z9 4
U1 0
U2 3
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2072-1439
EI 2077-6624
J9 J THORAC DIS
JI J. Thorac. Dis.
PD JUL
PY 2024
VL 16
IS 7
BP 4780
EP 4793
DI 10.21037/jtd-23-1431
PG 14
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA D3Y1F
UT WOS:001295564700027
PM 39144326
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lok, E
   Oe, T
   Ng, S
AF Lok, Evania
   Oe, Timothy
   Ng, Sally
TI Lower Extremity Traumatic Wound Management: Relative Significance of
   Negative Pressure Wound Therapy in the Orthopedic Setting
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE orthopedics; NPWT; NPWTi-d; open fracture; lower limb trauma wound
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; SEVERE OPEN FRACTURES;
   CLINICAL-EVALUATION; GRANULATION-TISSUE; GAUZE; INCISION; FLAPS; CARE;
   RECONSTRUCTION
AB Significance: Lower extremity traumatic wounds are associated with numerous perioperative challenges. Their etiologies determine the characteristics and extent of the injury. The timing of subsequent surgical intervention and wound healing optimization after lower extremity trauma are integral to successful perioperative lower extremity wound management.Recent Advances: Managing trauma to the lower extremities uses a multidisciplinary surgical approach. The objective of this review is to summarize lower limb trauma assessment, advancements in lower extremity trauma management, and the clinical applications of advanced wound care in lower limb traumatic wounds. The advent of lower limb reconstruction and the development of advanced wound care modalities have helped to improve the management of these complex injuries.Critical Issues: The extensive involvement of bone, soft tissues, nerves, and blood vessels of severe lower extremity trauma wounds presents a challenge for clinicians in both the acute care setting and during patient rehabilitation. If not properly managed, these injuries may be subject to a decline in limb function and may possibly result in limb loss. To reveal developing limb-threatening conditions, serial examinations should be performed.Future Directions: The majority of lower limb traumatic wound will benefit from the perioperative administration of an appropriate negative pressure wound therapy (NPWT)-based system, which can help to promote granulation tissue and remove wound exudate before definitive closure and/or reconstruction. NPWT should be included as an important adjunct in the surgical management of lower limb traumatic wounds.
C1 [Lok, Evania; Oe, Timothy; Ng, Sally] Austin Hlth, Dept Plast & Reconstruct Surg, 45 Studley Rd, Melbourne 3084, Australia.
   [Ng, Sally] Univ Melbourne, Dept Surg Austin Precinct, Melbourne, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; University of Melbourne
RP Ng, S (通讯作者)，Austin Hlth, Dept Plast & Reconstruct Surg, 45 Studley Rd, Melbourne 3084, Australia.; Ng, S (通讯作者)，Univ Melbourne, Dept Surg Austin Precinct, Melbourne, Australia.
EM sally.ng@austin.org.au
RI Ng, Sally/AAU-2796-2021
OI Ng, Sally/0000-0001-7332-627X
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NR 105
TC 4
Z9 4
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUL 1
PY 2025
VL 14
IS 7
BP 327
EP 343
DI 10.1089/wound.2023.0133
EA AUG 2024
PG 17
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 4LZ2B
UT WOS:001295581400001
PM 39001834
OA hybrid
DA 2026-07-24
ER
PT J
AU Davey, MG
   Donlon, NE
   Walsh, SR
   Donohoe, CL
AF Davey, Matthew G.
   Donlon, Noel E.
   Walsh, Stewart R.
   Donohoe, Claire L.
CA PROPEL 2 Trial Collaborators
TI Prophylactic negative pressure wound therapy (NPWT) in laparotomy wounds
   (PROPEL-2): protocol for a randomized clinical trial
SO BJS OPEN
LA English
DT Article
ID SURGICAL SITE INFECTION; PREVENTION; SURGERY; EPIDEMIOLOGY; COST
AB Background A proportion of patients undergoing midline laparotomy will develop surgical site infections after surgery. These complications place considerable financial burden on healthcare economies and have negative implications for patient health and quality of life. The prophylactic application of negative pressure wound therapy devices has been mooted as a pragmatic strategy to reduce surgical site infections. Nevertheless, further availability of multicentre randomized clinical trial data evaluating the prophylactic use of negative pressure wound therapy following midline laparotomy is warranted to definitely provide consensus in relation to these closure methods, while also deciphering potential differences among subgroups. The aim of this study is to determine whether prophylactic negative pressure wound therapy reduces postoperative wound complications in patients undergoing midline laparotomy.Methods PROPEL-2 is a multicentre prospective randomized clinical trial designed to compare standard surgical dressings (control arm) with negative pressure wound therapy dressings (Prevena (TM) and PICO (TM) being the most commonly utilized). Patient recruitment will include adult patients aged 18 years or over, who are indicated to undergo emergency or elective laparotomy. To achieve 90% power at the 5% significance level, 1006 patients will be required in each arm, which when allowing for losses to follow-up, 10% will be added to each arm, leaving the total projected sample size to be 2013 patients, who will be recruited across a 36-month enrolment period.Conclusion The PROPEL-2 trial will be the largest independent multicentre randomized clinical trial designed to assess the role of prophylactic negative pressure wound therapy in patients indicated to undergo midline laparotomy. The comparison of standard treatment to two commercially available negative pressure wound therapy devices will help provide consensus on the routine management of laparotomy wounds. Enrolment to PROPEL-2 began in June 2023. Registration number: NCT05977816 (http://www.clinicaltrials.gov).Conclusion The PROPEL-2 trial will be the largest independent multicentre randomized clinical trial designed to assess the role of prophylactic negative pressure wound therapy in patients indicated to undergo midline laparotomy. The comparison of standard treatment to two commercially available negative pressure wound therapy devices will help provide consensus on the routine management of laparotomy wounds. Enrolment to PROPEL-2 began in June 2023. Registration number: NCT05977816 (http://www.clinicaltrials.gov).
   The PROPEL-2 prospective, randomized study looking to evaluate the role of negative pressure wound therapy for laparotomy wounds.
C1 [Davey, Matthew G.; Donlon, Noel E.; Walsh, Stewart R.; Donohoe, Claire L.] Royal Coll Surgeons Ireland, Dept Surg Affairs, 121 St Stephens Green, Dublin, Ireland.
   [Davey, Matthew G.; Donlon, Noel E.; Walsh, Stewart R.; Donohoe, Claire L.] Natl Surg Res Support Ctr NSRSC, Dublin, Ireland.
C3 Royal College of Surgeons in Ireland - RCSI
RP Davey, MG (通讯作者)，Royal Coll Surgeons Ireland, Dept Surg Affairs, 121 St Stephens Green, Dublin, Ireland.
EM matthewdavey21@rcsi.ie
RI Davey, Matthew/ABF-8533-2021; Walsh, Stewart/AFZ-2791-2022; Donohoe,
   Claire/AAG-4770-2019
OI Wang, Shuang/0009-0005-5511-8027; Walsh, Stewart/0000-0002-1006-9541;
   Donohoe, Claire/0000-0001-9373-2662
FU Royal College of Surgeons in Ireland-National Surgical Research Support
   Centre (RCSI-NSRSC)
FX Funding support provided by the Royal College of Surgeons in
   Ireland-National Surgical Research Support Centre (RCSI-NSRSC).
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NR 43
TC 3
Z9 3
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD AUG 23
PY 2024
VL 8
IS 4
AR zrae081
DI 10.1093/bjsopen/zrae081
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA D5B9O
UT WOS:001296345500001
PM 39178168
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mingot, J
   Lanzalaco, S
   Ferreres, G
   Tzanov, T
   Alemán, C
   Armelin, E
AF Mingot, Julia
   Lanzalaco, Sonia
   Ferreres, Guillem
   Tzanov, Tzanko
   Aleman, Carlos
   Armelin, Elaine
TI Theranostic nano-enabled polyurethane eso-sponges coupled to surface
   enhanced Raman scattering for detection and control of bacteria killing
SO CHEMICAL ENGINEERING JOURNAL
LA English
DT Article
DE Polyurethane; Surface activation; Gold nanoparticles; Silver
   nanoparticles; Surface enhanced Raman scattering
ID SILVER NANOPARTICLES; MOLECULAR-MECHANISM; LIGNIN; ADHESIVE
AB Herein, a facile approach toward converting a three-dimensional polyurethane sponge (PUS), employed in endoluminal vacuum-assisted closure (endo-VAC) therapies, in a theranostic material able to detect and to inhibit bacteria growth, has been reported. The endo-VAC PUS presented sensitivity to Gram-positive and Gramnegative bacterial species thanks to its functionalization with gold and silver antibacterial nanoparticles (NPs). PUS with chitosan-stabilized Au-NPs achieved 5.26 f 0.17 logs and 2.78 f 0.34 logs of reduction of bacteria growth, whereas the sponges functionalized with phenolated lignin Ag-NPs offered slightly inferior values (4.77 f 0.36 logs and 2.03 f 0.37 logs, respectively), against Escherichia coli and Staphylococcus aureus pathogens, respectively, after the application of photothermal ablation. The in vitro antimicrobial studies were contrasted with the in-situ monitoring of bacteria localization and inactivation with excitation lasers of 532 and 785 nm wavelengths, respectively, in the Raman equipment. The novel theranostic nano-enabled antimicrobial PU sponges offer unprecedented possibilities for the improvement of the endo-VAC treatments and extrapolation of the methodology to other plastic-based implants to combat antimicrobial resistances.
C1 [Mingot, Julia; Lanzalaco, Sonia; Aleman, Carlos; Armelin, Elaine] Univ Politecnicacn Catalunya, Dept Engn Quim, IMEM BRT Grp, EEBE, C Eduard Maristany,10-14,Ed I,2 nd Floor, Barcelona 08019, Spain.
   [Mingot, Julia; Lanzalaco, Sonia; Aleman, Carlos; Armelin, Elaine] Univ Politecn Cataluna, Barcelona Res Ctr Multiscale Sci & Engn, C Eduard Maristany, 10-14, Basement S-1, Barcelona 08019, Spain.
   [Ferreres, Guillem; Tzanov, Tzanko] Univ Politecn Cataluna, Dept Engn Quim, GBMI Grp, ETSEIAAT, TR14 Rambla St Nebridi 22, Terrassa 08222, Spain.
   [Aleman, Carlos] Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, C Baldiri Reixac 10-12, E-08028 Barcelona, Spain.
C3 Universitat Politecnica de Catalunya; Universitat Politecnica de
   Catalunya; Universitat Politecnica de Catalunya; University of
   Barcelona; Barcelona Institute of Science & Technology; Institut de
   Bioenginyeria de Catalunya
RP Lanzalaco, S; Armelin, E (通讯作者)，Univ Politecnicacn Catalunya, Dept Engn Quim, IMEM BRT Grp, EEBE, C Eduard Maristany,10-14,Ed I,2 nd Floor, Barcelona 08019, Spain.
EM sonia.lanzalaco@upc.edu; elaine.armelin@upc.edu
RI Alemán, Carlos/AAA-9954-2020; Mingot, Júlia/PJB-3223-2026; Armelin,
   Elaine/M-9375-2015; Lanzalaco, Sonia/M-9384-2016; Tzanov,
   Tzanko/F-1140-2016
OI Ferreres Cabanes, Guillem/0000-0003-3138-8506
FU MCIN/AEI [PID2021-125257OB-I00, CEX2023-001300-M]; ERDF "A way of making
   Europe"; European Union; Agencia de Gestio d'Ajuts Universitaris i de
   Recerca-AGAUR [2021SGR00387]; Horizon project "An Open Innovation Test
   Bed for Nano-Enabled Bio-Based PUR Foams and Composites" (BIOMAT)
   [H2020-953270]; AGAUR [2021 FISDU 00287]; Universitat Politecnica de
   Catalunya and Banco Santander [113 FPI-UPC 2018]; Generalitat de
   Catalunya
FX This project has received funding from the Grant PID2021-125257OB-I00,
   by MCIN/AEI/10.13039/501100011033 and by ERDF "A way of making Europe",
   by the European Union and from the Agencia de Gestio d'Ajuts
   Universitaris i de Recerca-AGAUR (2021SGR00387) and by Horizon 2020
   project "An Open Innovation Test Bed for Nano-Enabled Bio-Based PUR
   Foams and Composites" (BIOMAT), (H2020-953270). J. Mingot acknowledges
   the support of AGAUR for her PhD fellowship funding (Grant no 2021 FISDU
   00287). G. F acknowledges Universitat Politecnica de Catalunya and Banco
   Santander for his PhD grant (113 FPI-UPC 2018) . "This work is part of
   Maria de Maeztu Units of Excellence Programme CEX2023-001300-M/funded by
   MCIN/AEI/10.13039/501100011033". Support for the research of C. Aleman
   and T. Tzanov was also received through the prize "ICREA Academia" for
   excellence in research funded by the Generalitat de Catalunya.
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NR 98
TC 5
Z9 5
U1 6
U2 23
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1385-8947
EI 1873-3212
J9 CHEM ENG J
JI Chem. Eng. J.
PD OCT 1
PY 2024
VL 497
AR 154617
DI 10.1016/j.cej.2024.154617
EA AUG 2024
PG 15
WC Engineering, Environmental; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA D6M7W
UT WOS:001297310900001
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Ren, S
   Luo, Y
   Shen, XY
   Wu, Q
   Wu, XH
   Ma, C
   Xiong, ZW
   Gong, R
   Liu, Z
   Chen, JC
   Wang, W
AF Ren, Sen
   Luo, Yun
   Shen, Xiaoyong
   Wu, Qian
   Wu, Xiaohui
   Ma, Chao
   Xiong, Zhongwei
   Gong, Rui
   Liu, Zheng
   Chen, Jincao
   Wang, Wei
TI Vacuum Sealing Drainage against Surgical Site Infection after
   Intracranial Neurosurgery
SO SURGICAL INFECTIONS
LA English
DT Article
DE debridement; intracranial infection; neurosurgery; surgical site
   infection; vacuum sealing drainage
ID PRESSURE WOUND THERAPY; RISK-FACTORS; CRANIOTOMY; PREVENTION;
   CRANIOPLASTY; RATES
AB Background: Surgical site infections (SSIs) remain a conundrum for neurosurgeons. This study examines the efficacy and outcome of vacuum sealing drainage (VSD) in the treatment of pyogenic SSIs following intracranial neurosurgery.Methods: Twenty patients with SSIs, who received surgical intervention, were treated retrospectively with VSD during the past five years. Primary surgical procedure types, SSI types, VSD replacements, pathogenic germs, antibiotic therapy, and infection control were reviewed and discussed.Results: Of the 20 infections, 13 (65%) were extradural and 7 (35%) were extradural SSIs combined with intracranial infections (including 5 meningitis, 1 subdural abscess, and 1 brain abscess). All the patients consented to medical device implantation (including 5 titanium webs, 6 bone flap fixation devices, and 12 duraplasties), most of which were removed during debridement. The median duration from primary surgical procedure to an SSI diagnosis was 19 days (range: 7 to 365 d). All the patients also agreed to debridement and VSD treatment; VSD was replaced 0 to 5 times (median, one time) every 4 to 7 days and kept for 4 to 35 days (median, 14 d). Seven (35%) patients had defined bacterial infections, with Staphylococcus aureus being the dominant infection. The deployed standard VSD and antibiotic treatment ensured full recovery from SSIs, including from intracranial infections: 14 (70%) patients had recovered fully by follow-up, and no infection-associated death was registered; 6 (30%) patients died of severe primary affections.Conclusion: VSD-assisted therapy is safe and effective against SSIs after intracranial neurosurgery.
C1 [Ren, Sen; Wu, Qian; Wu, Xiaohui; Ma, Chao; Xiong, Zhongwei; Gong, Rui; Liu, Zheng; Chen, Jincao; Wang, Wei] Wuhan Univ, Zhongnan Hosp, Dept Neurosurg, Wuhan 430071, Hubei, Peoples R China.
   [Luo, Yun] Wuhan Univ, Dept Crit Care Med, Zhongnan Hosp, Wuhan, Peoples R China.
   [Shen, Xiaoyong] Wuhan Univ, Hosp Stomatol, Wuhan, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University
RP Chen, JC; Wang, W (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Neurosurg, Wuhan 430071, Hubei, Peoples R China.
EM chenjc2020@126.com; wangwei820805@hotmail.com
RI sen, ren/KFF-5502-2024
OI sen, ren/0000-0002-3674-885X
FU National Natural Science Foundation of China [82302814]; Fundamental
   Research Funds for the Central Universities [2042022kf1142]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 82302814) and the Fundamental Research Funds for the
   Central Universities (2042022kf1142).
CR Abode-Iyamah KO, 2018, J NEUROSURG, V128, P1241, DOI 10.3171/2016.12.JNS161967
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   [Anonymous], 2024, CDCNHSN SURVEILLANCE
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NR 32
TC 0
Z9 1
U1 1
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD DEC 1
PY 2024
VL 25
IS 10
BP 728
EP 736
DI 10.1089/sur.2024.032
EA AUG 2024
PG 9
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA O0Y1X
UT WOS:001297453600001
PM 39187266
DA 2026-07-24
ER
PT J
AU Dohmen, J
   Weissinger, D
   Peter, AST
   Theodorou, A
   Kalff, JC
   Stoffels, B
   Lingohr, P
   von Websky, M
AF Dohmen, J.
   Weissinger, D.
   Peter, A. S. T.
   Theodorou, A.
   Kalff, J. C.
   Stoffels, B.
   Lingohr, P.
   von Websky, M.
TI Evaluating a novel vertical traction device for early closure in open
   abdomen management: a consecutive case series
SO FRONTIERS IN SURGERY
LA English
DT Article
DE open abdomen (OA); abdominal compartment syndrome (ACS); temporary
   abdominal closure (TAC); definitive fascial closure (DFC); vertical
   traction device (VTD); negative pressure wound therapy (NPWT)
ID ABDOMINAL COMPARTMENT SYNDROME; PRESSURE WOUND THERAPY; DAMAGE-CONTROL;
   LAPAROTOMY
AB Background In emergency surgery, managing abdominal sepsis and critically ill patients with imminent abdominal compartment syndrome (ACS) using an open abdomen (OA) approach has become standard practice for damage control. To prevent significant complications associated with OA therapy, such as abdominal infections, entero-atmospheric fistula (EAF), and abdominal wall hernia formation, early definitive fascial closure (DFC) is crucial. This study aims to assess the feasibility of a novel device designed to facilitate early fascial closure in patients with an open abdomen.Methods Between 2019 and 2020, nine patients undergoing open abdomen management were enrolled in this study. All patients were treated using vertical mesh-mediated fascial traction combined with a novel vertical traction device (VTD). Data from these cases were collected and retrospectively analyzed.Results In this study, all patients were treated with OA due to impending ACS. Three patients died before achieving DFC, while the remaining six patients successfully underwent DFC. The mean number of surgical procedures after OA was 3 +/- 1, and the mean time to DFC was 9 +/- 3 days. The use of the VTD in combination with negative pressure wound therapy (NPWT) resulted in a 76% reduction in fascia-to-fascia distance until DFC was achieved. The application of the VTD did not affect ventilation parameters or the Simplified Acute Physiology Score II (SAPS II), but intra-abdominal pressure (IAP) was reduced from 31 +/- 8 mmHg prior to OA to 8.5 +/- 2 mmHg after applying the device. The primary complication associated with the device was skin irritation, with three patients developing skin blisters as the most severe manifestation.Conclusion Overall, the novel VTD appears to be a safe and feasible option for managing OA cases. It may reduce complications associated with OA by promoting early definitive fascial closure.
C1 [Dohmen, J.; Weissinger, D.; Peter, A. S. T.; Kalff, J. C.; Lingohr, P.] Univ Bonn, Dept Surg, Bonn, Germany.
   [Theodorou, A.] Ippokrateio Univ Hosp Athens, Dept Surg, Athens, Greece.
   [Stoffels, B.] Cellitinnen Hosp Holy Spirit, Dept Gen & Visceral Surg, Trauma Surg, Cologne, Germany.
   [von Websky, M.] RWTH Aachen Univ Hosp, Dept Gen Visceral & Transplantat Surg, Aachen, Germany.
C3 University of Bonn; RWTH Aachen University; RWTH Aachen University
   Hospital
RP Dohmen, J (通讯作者)，Univ Bonn, Dept Surg, Bonn, Germany.
EM jonas.dohmen@ukbonn.de
RI Dohmen, Jonas/LSL-3019-2024; Kalff, Joerg/U-8580-2017
OI Dohmen, Jonas/0000-0002-6907-3844; 
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
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NR 37
TC 6
Z9 9
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD AUG 13
PY 2024
VL 11
AR 1449702
DI 10.3389/fsurg.2024.1449702
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA D6W3A
UT WOS:001297562300001
PM 39193403
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yang, QH
   Ren, XY
   Fang, XW
   Ding, JX
AF Yang, Qinghua
   Ren, Xiaoying
   Fang, Xiaowan
   Ding, Jiaxiang
TI The efficacy of cuff-shaving combined with negative pressure wound
   therapy in refractory exit-site and tunnel infections: a single center
   experience
SO BMC NEPHROLOGY
LA English
DT Article
DE Negative pressure wound therapy; Peritoneal dialysis catheter;
   Refractory exit-site infection; Superficial cuff-shaving; Tunnel
   infection
ID PREVENTION; REMOVAL
AB BackgroundRefractory exit-site infections (ESIs) and tunnel infections (TIs) are challenging complications for patients undergoing peritoneal dialysis (PD). This study compared the outcomes of surgical intervention, notably the cuff-shaving (CS) procedure coupled with negative-pressure wound therapy (NPWT), and conservative management strategies for patients with refractory ESI and TI.MethodsWe retrospectively reviewed patients who underwent PD at our center, focusing on the incidence and management of ESI and TI. We evaluated and compared treatment outcomes, including ESI scores, frequency of ESI and/or TI, identification of causative microorganisms, and duration of catheter survival or time until removal.ResultsWe identified 97 episodes of catheter-related ESI and/or TI across 71 patients with an incidence rate of 0.15 episodes per patient-year. Of the 23 patients with refractory ESI and/or TI, surgical intervention was performed in 8, while 15 chose conservative management. In the one-month follow-up, patients who underwent CS combined with NPWT showed no complications such as leakage, and their local symptoms resolved completely. The mean PD catheter survival time was significantly longer in the surgical group (29.38 +/- 7.25 months) than in the conservative group (7.86 +/- 2.13 months). Surgical intervention demonstrated a significantly higher therapeutic efficacy and extended catheter survival.ConclusionsThe combination of CS and NPWT as a surgical approach is crucial for eradicating infectious foci and significantly improving the longevity of PD catheter function. This integrated surgical strategy offers a promising solution for the management of refractory ESI and TI in patients undergoing PD.
C1 [Yang, Qinghua; Ren, Xiaoying; Fang, Xiaowan; Ding, Jiaxiang] Peking Univ Int Hosp, Nephrol Dept, 1 Life Pk Rd,Life Sci Pk Zhongguancun, Beijing 102206, Peoples R China.
C3 Peking University
RP Ding, JX (通讯作者)，Peking Univ Int Hosp, Nephrol Dept, 1 Life Pk Rd,Life Sci Pk Zhongguancun, Beijing 102206, Peoples R China.
EM Dingjiaxiang@pkuih.edu.cn
FU Peking University International Hospital Research Funds
FX No Statement Available
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NR 19
TC 0
Z9 0
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2369
J9 BMC NEPHROL
JI BMC Nephrol.
PD AUG 26
PY 2024
VL 25
IS 1
AR 273
DI 10.1186/s12882-024-03714-8
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA D7G3O
UT WOS:001297825800001
PM 39187762
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jia, B
   Xue, R
   Li, J
   Guo, JC
   Liu, JN
AF Jia, Bei
   Xue, Rui
   Li, Jia
   Guo, Jichao
   Liu, Jianning
TI Novel insights into vancomycin-loaded calcium sulfate and negative
   pressure wound therapy in preventing infections in open fractures
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Open fractures; Staphylococcus aureus infections; Vancomycin-Loaded
   Calcium Sulfate; Negative pressure wound therapy; Macrophage
   polarization; M2
AB BackgroundOpen fractures are challenging due to susceptibility to Staphylococcus aureus infections. This study examines the impact of Vancomycin-Loaded Calcium Sulfate (VLCS) and negative pressure wound therapy (NPWT) on macrophage behavior in enhancing healing and infection resistance. Both VLCS and NPWT were evaluated individually and in combination to determine their effects on macrophage polarization and infection resistance in open fractures.MethodsThrough single-cell RNA sequencing, genomic expressions in macrophages from open fracture patients treated with VLCS and NPWT were compared to a control group. The analysis focused on MBD2 gene changes related to macrophage polarization.ResultsRemarkable modifications in MBD2 expression in the treatment group indicate a shift towards M2 macrophage polarization. Additionally, the combined treatment group exhibited greater improvements in infection resistance and healing compared to the individual treatments. This shift suggests a healing-promoting atmosphere with improved infection resilience.ConclusionsVLCS and NPWT demonstrate the ability to alter macrophage behavior toward M2 polarization, which is crucial for infection prevention in open fractures. The synergistic effect of their combined use shows even greater promise in enhancing outcomes in orthopedic trauma care.
C1 [Jia, Bei] Hebei Med Univ, Hosp 1, Nosocomial Infect Management Dept, 89 Donggang Rd, Shijiazhuang, Peoples R China.
   [Xue, Rui; Li, Jia; Guo, Jichao; Liu, Jianning] Hebei Med Univ, Hosp 3, Dept Orthopaed Surg, 139 ZiQiang Rd, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Liu, JN (通讯作者)，Hebei Med Univ, Hosp 3, Dept Orthopaed Surg, 139 ZiQiang Rd, Shijiazhuang, Hebei, Peoples R China.
EM 37900477@hebmu.edu.cn
FU National Outstanding Youth Science Fund Project of National Natural
   Science Foundation of China
FX None.
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NR 41
TC 1
Z9 2
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD AUG 29
PY 2024
VL 19
IS 1
AR 517
DI 10.1186/s13018-024-04931-5
PG 16
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA E0F3O
UT WOS:001299846100001
PM 39198853
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Du, YP
   Yu, YN
   Xu, SN
   Yang, J
   Liu, Y
   Tang, Y
   Chu, CY
AF Du, Yanping
   Yu, Yanan
   Xu, Shaona
   Yang, Jie
   Liu, Ying
   Tang, Yu
   Chu, Cuiying
TI Antibiotic bone cement combined with vacuum sealing drainage effectively
   repairs sacrococcygeal pressure ulcer
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Antibiotic bone cement; vacuum sealing drainage; sacrococcygeal pressure
   ulcer
ID INJURY
AB Objective: To investigate the effectiveness of antibiotic bone cement combined with the vacuum sealing drainage (VSD) technique for repairing sacrococcygeal pressure ulcer wounds. Methods: A retrospective analysis was conducted on data from 136 patients treated at Yantai Affiliated Hospital of Binzhou Medical College between May 2020 and June 2022. The cases were devided into a control group and a study group according to their treatment regimen. Indicators of postoperative recovery including blood routine recovery time, hospital stay, antibiotic application time, and healing time were compared between the two groups. Before the procedure and 6, 12, 24, and 48 hours following the operation, the pain levels of patients in both groups were examined using a visual analogue scale (VAS). On the 3rd, 7th, 14th, 21st, and 28th days of treatment, the pressure ulcer scale for healing (PUSH) was used to measure the pressure ulcer area between the two groups. On the 7th, 14th, 21st, and 28th days following treatment, the capillary density values were compared between the two groups, along with the levels of interleukin-beta (IL-1 beta), interleukin-12 (IL-12), and C-reactive protein (CRP). The proportions of immunoglobulin M (IgM) and immunoglobulin G (IgG) levels, CD3+, CD4+, and CD8+ T cell subsets, as well as CD4+/CD8+ ratio, were compared between the two groups. Results: The blood routine recovery time, hospital stays, antibiotic usage duration, and healing time were all significantly shorter in the study group compared to those in the control group (all P <0.05). At 6 h, 12 h, 24 h, and 48 h following surgery, the VAS score in study group was significantly lower than that of the control group (P<0.05). P <0.05). The study group also showed a greater reduction in pressure ulcer area, with lower PUSH scores observed on days 14, 21, and 28 (P<0.05). P <0.05). Post-treatment levels of IL-1 beta, IL-12, and CRP decreased in both groups, with significantly lower levels in the study group (P<0.05). P <0.05). Following therapy, both groups demonstrated significantly increased levels of CD3+, CD4+, CD4+/CD8+, IgM and IgG and reduced level of CD8+. These improvements were more pronounced in the study group (all P <0.05). Conclusion: The combination of antibiotic bone cement and VSD is effective in enhancing recovery, reducing pain and inflammation, and improving immune response in the treatment of sacrococcygeal pressure ulcers.
C1 [Du, Yanping; Yu, Yanan; Liu, Ying] Binzhou Med Univ, Yantai Affiliated Hosp, Dept Neurosurg, Yantai 264100, Shandong, Peoples R China.
   [Xu, Shaona] Binzhou Med Univ, Yantai Affiliated Hosp, Dept Spine Surg, Yantai 264100, Shandong, Peoples R China.
   [Yang, Jie] Binzhou Med Univ, Yantai Affiliated Hosp, Dept Endoscopy Ctr, Yantai 264100, Shandong, Peoples R China.
   [Tang, Yu] Binzhou Med Univ, Coll Basic Med, Yantai 264000, Shandong, Peoples R China.
   [Chu, Cuiying] Binzhou Med Univ, Yantai Affiliated Hosp, Dept Trauma Ctr, 717 Jinbu St, Yantai 264100, Shandong, Peoples R China.
C3 Shandong Medical & Pharmaceutical University; Shandong Medical &
   Pharmaceutical University; Shandong Medical & Pharmaceutical University;
   Shandong Medical & Pharmaceutical University; Shandong Medical &
   Pharmaceutical University
RP Chu, CY (通讯作者)，Binzhou Med Univ, Yantai Affiliated Hosp, Dept Trauma Ctr, 717 Jinbu St, Yantai 264100, Shandong, Peoples R China.
EM ytccy9977@163.com
FU Binzhou Medical University, Clinical study of fascial tis-sue combing
   combined with MEBT/MEBO [BY2020XRX010]
FX Acknowledgements This research was supported by Binzhou Medical
   University, Clinical study of fascial tis-sue combing combined with
   MEBT/MEBO to induce the original flavor regeneration of deep wound
   multilayertissues (No. BY2020XRX010) .
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NR 30
TC 3
Z9 6
U1 0
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2024
VL 16
IS 8
BP 4042
EP 4051
DI 10.62347/RYCD5610
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA E1K7H
UT WOS:001300671800057
PM 39262721
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Tapking, C
   Endlein, J
   Warszawski, J
   Kotsougiani-Fischer, D
   Gazyakan, E
   Hundeshagen, G
   Hirche, C
   Trofimenko, D
   Burkard, T
   Kneser, U
   Fischer, S
AF Tapking, C.
   Endlein, J.
   Warszawski, J.
   Kotsougiani-Fischer, D.
   Gazyakan, E.
   Hundeshagen, G.
   Hirche, C.
   Trofimenko, D.
   Burkard, T.
   Kneser, U.
   Fischer, S.
TI Negative pressure wound therapy in burns: a prospective,
   randomized-controlled trial
SO BURNS
LA English
DT Article
DE Burns; Negative pressure wound therapy; Wound healing
ID QUALITY-OF-LIFE; VACUUM-ASSISTED CLOSURE; FUNCTIONAL OUTCOMES;
   MANAGEMENT; DRESSINGS; COST; PAIN
AB Background: Negative-pressure-wound-therapy (NPWT) has become a widely used tool for the coverage and active treatment of complex wounds, including burns. This study aimed to evaluate the effectiveness of NPWT in acute burns of upper and lower extremities and to compare results to the standard-of-care (SOC) at our institution. Methods: Patients that were admitted to our institution between May 2019 and November 2021 with burns on extremities between 0.5 % and 10 % of the total body surface area (%TBSA) were included and randomized to either NPWT or SOC (polyhexanide gel, fatty gauze, and cotton wool). Treatment was performed until complete wound healing. Patients that required skin grafts, received additional NPWT after grafting independent on the initial group allocation. Results: Sixty-five patients suffering from burn injury between May 2019 and November 2021 were randomized into treatment with NPWT (n = 33) or SOC (n = 32); of these, 33 patients (NPWT) and 28 patients (SOC) had complete data sets and were included in the analysis. Both groups were similar regarding age (39.8 +/- 13.7 vs. 44.8 +/- 16.2 years,p = 0.192), total burn size (3.1 +/- 2.3 vs. 3.4 +/- 2.8 %TBSA,p = 0.721) and treated wound size (1.9 +/- 1.2 vs. 1.5 +/- 0.8 %TBSA,p = 0.138). We found no differences regarding healing time (11.0 +/- 4.9 vs. 8.6 +/- 3.8,p = 0.074, and significant differences in a number of dressing changes throughout the study (2.4 +/- 1.5 vs 4.2 +/- 1.9,p < 0.001). The Kaplan-Meier time-to-event analysis exhibited no statistically significant difference in the time to healing or skin grafting (p = 0.085) in NPWT group compared with SOC group. The median time to healing or skin grafting was 10(8-11) days for NPWT and 9(7-11) days for SOC. The hazard ratio for healing or skin graft was HR= 0.64(0.38-1.08). The results of the time-to-event analysis as well as the Kaplan-Meier curve on the PPS confirmed this result. We found no differences in secondary surgical operations 15.2 vs 21.4 % pain or functional outcomes. Conclusions: In this study, we found no significant difference between the two groups in terms of time to detect wound healing. We also found no difference regarding further operations for wound closure, pain and/or scarring. However, dressing changes were significantly less frequent for patients that were treated with NPWT, which may be a psychological and logistical advantage.
C1 [Tapking, C.; Endlein, J.; Kotsougiani-Fischer, D.; Gazyakan, E.; Hundeshagen, G.; Kneser, U.; Fischer, S.] Heidelberg Univ, Burn Ctr, Dept Hand Plast & Reconstruct Surg, Microsurg, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
   [Warszawski, J.; Hirche, C.] BG Unfallklin Frankfurtam Main GmbH, Replantat Ctr, Dept Plast Hand & Reconstruct Microsurg, Frankfurt, Germany.
   [Kotsougiani-Fischer, D.; Fischer, S.] AESTHETIKON, private practice plast & aesthet Surg, Heidelberg, Germany.
   [Trofimenko, D.] Lohmann & Rauscher GmbH & Co KG, Dept Clin Regulatory Affairs QRA RA C, Neuwied, Germany.
   [Burkard, T.] Anfomed Gmbh, Mohrendorf, Germany.
C3 Ruprecht Karls University Heidelberg; Lohmann & Rauscher (L&R)
RP Fischer, S (通讯作者)，Heidelberg Univ, Burn Ctr, Dept Hand Plast & Reconstruct Surg, Microsurg, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
EM fischer@aesthetikon.de
RI Trofimenko, Daria/QLV-7225-2026; Gazyakan, Emre/HLW-5585-2023; Hirche,
   Christoph/GYA-4981-2022; Burkard, Thilo/N-7533-2014
OI Trofimenko, Daria/0009-0001-2179-9937; 
FU Lohmann & Rauscher, Rengsdorf, Germany
FX This study was funded by Lohmann & Rauscher, Rengsdorf, Germany. Our
   institution received a compensation per included patient. S. Fischer and
   D. Kotsougiani-Fischer served as consultants for Lohmann & Rauscher,
   Rengsdorf, Germany.
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NR 39
TC 5
Z9 6
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD SEP
PY 2024
VL 50
IS 7
BP 1840
EP 1847
DI 10.1016/j.burns.2024.04.005
EA AUG 2024
PG 8
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA E4N6Z
UT WOS:001302793200001
PM 38724347
DA 2026-07-24
ER
PT J
AU Rampi, A
   Comini, LV
   Galli, A
   Howardson, BO
   Tettamanti, A
   Luparello, P
   Redaelli, G
   Di Santo, D
   Bondi, S
AF Rampi, Andrea
   Comini, Lara Valentina
   Galli, Andrea
   Howardson, Bright Oworae
   Tettamanti, Alberto
   Luparello, Paolo
   Redaelli, Gabriele
   Di Santo, Davide
   Bondi, Stefano
TI Reconstructive Surgery of the Head and Neck in Organ Transplant
   Recipients: A Case Report and a Review of the Literature
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE head and neck surgery; solid organ recipients; wound healing;
   immunosuppressive agents; reconstructive flaps
ID WOUND-HEALING COMPLICATIONS; KIDNEY-TRANSPLANTATION;
   LIVER-TRANSPLANTATION; CANCER INCIDENCE; RISK; IMMUNOSUPPRESSION;
   TACROLIMUS; COHORT
AB The number of solid organ transplant recipients (SOTRs) is growing as a consequence of an increase in transplantations and longer survival; these patients, thus, frequently suffer various comorbidities and are subjected to the detrimental effects of immunosuppressive agents, which expose them to a higher risk of developing malignancies. These drugs also complicate the surgical treatment of neoplasms, as they can hinder wound healing, especially when associated with other unfavorable factors (e.g., previous radiotherapy, diabetes, etc.). We herein present our experience with a 74-year-old SOTR who underwent a radical extended parotidectomy and reconstruction with a submental island flap for a persistent cutaneous squamous carcinoma after radiotherapy; his complicated clinical course was characterized by incredibly slow wound healing. The current literature was reviewed to provide a succinct overview of the main difficulties of head and neck surgery in SOTRs. In particular, the immunosuppressive regimen can be tapered considering the individual risk and other elements should be carefully assessed, possibly prior to surgery, to prevent cumulative harm. New developments, including intraoperative monitoring of flap vascularization through indocyanine green fluorescence video-angiography and the prophylactic application of negative pressure wound therapy, when feasible, may be particularly beneficial for high-risk patients.
C1 [Rampi, Andrea; Redaelli, Gabriele] Sondrio Hosp, Otorhinolaryngol Unit, ASST Valtellina & Alto Lario, I-23100 Sondrio, Italy.
   [Comini, Lara Valentina; Luparello, Paolo; Di Santo, Davide; Bondi, Stefano] FPO IRCCS, Candiolo Canc Inst, Otorhinolaryngol Head & Neck Surg, I-10060 Turin, Italy.
   [Galli, Andrea; Howardson, Bright Oworae; Tettamanti, Alberto] IRCCS San Raffaele Sci Inst, Div Head & Neck Dept, Otorhinolaryngol Unit, I-20132 Milan, Italy.
   [Galli, Andrea; Howardson, Bright Oworae; Tettamanti, Alberto] Univ Vita Salute San Raffaele, Sch Med, I-20132 Milan, Italy.
C3 IRCCS Fondazione del Piemonte per l'Oncologia; Vita-Salute San Raffaele
   University; IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele
   University
RP Galli, A (通讯作者)，IRCCS San Raffaele Sci Inst, Div Head & Neck Dept, Otorhinolaryngol Unit, I-20132 Milan, Italy.; Galli, A (通讯作者)，Univ Vita Salute San Raffaele, Sch Med, I-20132 Milan, Italy.
EM galli1.andrea@hsr.it; stefano.bondi@ircc.it
RI Galli, Andrea/I-4821-2019; Di Santo, Davide/AAN-6965-2020; Comini, Lara
   Valentina/KOC-1450-2024
OI Galli, Andrea/0000-0003-2677-8091; Tettamanti,
   Alberto/0009-0009-7260-9126; Bondi, Stefano/0000-0002-9163-5540; Di
   Santo, Davide/0000-0002-8239-3850; Comini, Lara
   Valentina/0000-0002-3639-1504
CR Acuna SA, 2018, TRANSPLANT REV-ORLAN, V32, P218, DOI 10.1016/j.trre.2018.07.001
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   Bootun R, 2013, INT WOUND J, V10, P98, DOI 10.1111/j.1742-481X.2012.00950.x
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   Dantal J, 1998, LANCET, V351, P623, DOI 10.1016/S0140-6736(97)08496-1
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   Galli A, 2022, ANN SURG ONCOL, V29, P8362, DOI 10.1245/s10434-022-12298-2
   Galli A, 2022, CANCERS, V14, DOI 10.3390/cancers14020347
   Giordano L, 2022, ANN SURG ONCOL, V29, P8361, DOI 10.1245/s10434-022-12171-2
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   Ueno P, 2017, TRANSPLANTATION, V101, P844, DOI 10.1097/TP.0000000000001392
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NR 42
TC 2
Z9 3
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2024
VL 13
IS 16
AR 4790
DI 10.3390/jcm13164790
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA E7O0U
UT WOS:001304850400001
PM 39200933
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kato, H
   Kano, S
   Yoshimitsu, M
   Nakagawa, Y
   Yasui, Y
   Nakamura, M
   Morita, A
AF Kato, Hiroshi
   Kano, Shinji
   Yoshimitsu, Maki
   Nakagawa, Yua
   Yasui, Yukiko
   Nakamura, Motoki
   Morita, Akimichi
TI Comparative analysis of one-step and two-step full thickness skin
   grafting and secondary intention healing for skin defects after surgical
   management of plantar malignant melanoma
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE graft survival; lymph node; melanoma; negative-pressure wound therapy;
   weight-bearing
ID METASTASIS; CLOSURE; FOOT
AB Plantar malignant melanoma is largely managed surgically, particularly in its early stages. However, the plantar region has a lower survival rate of skin grafts than other regions. Furthermore, complete wound healing occurs over a long period of time, postoperatively. Thus, in this study, we retrospectively analyzed the use of skin grafts to reconstruct skin defects, as postoperative complications of plantar malignant melanoma. Forty-nine patients, (23 males, 26 females; mean age 70.4-years) underwent excisional surgery for plantar malignant melanoma at our hospital, between March 2018 and December 2022. The time from initial surgery to wound healing was analyzed, using a multivariate Cox proportional hazards model, to identify related factors. We excluded cases with lesions in non-weight-bearing areas and cases with segmental layer grafts, based on multivariate analysis, to eliminate bias when comparing a one-step resection and reconstruction technique to resection followed by waiting for granulation to occur before reconstruction. Patients were categorized into three cohorts. The first and second cohorts had undergone one-step and two-step skin grafting, respectively. Patients in the third cohort underwent secondary intention healing without skin grafting. The results revealed that the factors associated with wound-healing time included a defect size of >1800 mm2, in addition to two-step and split-thickness skin grafting. Therefore, Kaplan-Meier curves were constructed across the three cohorts, based on the data of 37 patients. Nine cases of non-weight-bearing areas and three cases of split-thickness skin grafts were excluded from the original total of 49 patients. The median times from the initial surgery to wound healing were 14.6, 12.0, and 21.9 weeks for the one- and two-step skin grafting and secondary intention healing cohorts, respectively. A statistically significant difference in the treatment time between the skin grafting and secondary intention healing cohorts was observed (p < 0.001) Moreover, a statistically significant difference in the treatment time between the one- and two-step skin grafting cohorts was noted (p = 0.046). Thus, two-step skin grafting after surgical treatment for plantar malignant melanoma may shorten the overall treatment duration by allowing granulation to occur.
C1 [Kato, Hiroshi; Kano, Shinji; Yoshimitsu, Maki; Nakagawa, Yua; Yasui, Yukiko; Nakamura, Motoki; Morita, Akimichi] Nagoya City Univ, Grad Sch Med Sci, Dept Geriatr & Environm Dermatol, 1-Kawasumi,Mizuho Cho,Mizuho Ku, Nagoya 4678601, Japan.
C3 Nagoya City University
RP Kato, H (通讯作者)，Nagoya City Univ, Grad Sch Med Sci, Dept Geriatr & Environm Dermatol, 1-Kawasumi,Mizuho Cho,Mizuho Ku, Nagoya 4678601, Japan.
EM h-kato@med.naogya-cu.ac.jp
RI ; Nakamura, Motoki/JNT-1917-2023
OI Yasui, Yukiko/0000-0003-0961-6007; Morita, Akimichi/0000-0001-8372-3754;
   Nakamura, Motoki/0000-0003-4431-7782
FX We thank Editage () for English language editing.
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NR 15
TC 4
Z9 4
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD DEC
PY 2024
VL 51
IS 12
BP 1641
EP 1645
DI 10.1111/1346-8138.17398
EA SEP 2024
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA O6N7C
UT WOS:001305006800001
PM 39229708
DA 2026-07-24
ER
PT J
AU Lech, GE
   Neves, BH
   Oliveira, GT
   da Silveira, CAB
   Kasmirski, JA
   Lima, DL
   Cavazzola, LT
AF Lech, Gabriele Eckerdt
   Neves, Brian Henriques
   Oliveira, Gilson Tenorio
   da Silveira, Carlos Andre Balthazar
   Kasmirski, Julia Adriana
   Lima, Diego L.
   Cavazzola, Leandro Totti
TI Vacuum-assisted wound closure and mesh-mediated fascial traction for
   temporary closure in open abdomen: A single-arm meta-analysis
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
DE enteroatmospheric fistula; incisional hernia; negative pressure wound
   therapy; open abdomen
ID QUALITY-OF-LIFE; THERAPY; MANAGEMENT
AB IntroductionOpen abdomen (OA) therapy is used in the management of patients who require surgery for severe abdominal conditions. This meta-analysis aims to evaluate the VAWCM technique regarding short and long-term outcomes.MethodsPubMed, Embase, and Cochrane Central were systematically searched for studies that analyzed VAWCM therapy in OA. Primary outcomes were the complete fascial closure rate and mean duration of OA treatment. Statistical analyses were performed using R statistical software.ResultsSeven studies comprising 535 patients were included. We found a complete fascial closure rate of 77.3 per 100 patients (80.1%; 95% CI 59.6-88.7; I2 = 76%), with an overall mortality of 30.3 per 100 (33.5%; 95% CI 9.3-19.4; I2 = 78%). The pooled mean duration of OA treatment was 14.6 days (95% CI 10.7-18.6; I2 = 93%), while the mean length of hospital stay was 43.3 days (95% CI 21.2-65.3; I2 = 96%). As additional outcomes, we found an enteroatmospheric fistula rate of 5.6 per 100 patients (5.4%; 95% CI 2.3-13.3; I2 = 45%) and incisional hernia rate of 34.7 per 100 (34.6%; 95% CI 28.9-41.1; I2 = 0%). The subgroup analysis of mesh materials (polypropylene or polyglactin) showed a higher complete fascial closure rate for the polyglactin (89.1% vs. 66.6%; p = 0.02).ConclusionOur findings showed that VAWCM is a viable option for OA treatment, successfully reaching complete fascial closure, with a low duration of the technique, even though it presented a high heterogeneity between the studies.
C1 [Lech, Gabriele Eckerdt] Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil.
   [Neves, Brian Henriques] Grande Rio Univ, Rio De Janeiro, Brazil.
   [Oliveira, Gilson Tenorio; da Silveira, Carlos Andre Balthazar] Bahiana Sch Med & Publ Hlth, Salvador, BA, Brazil.
   [Kasmirski, Julia Adriana] Univ Sao Paulo, Sao Paulo, Brazil.
   [Lima, Diego L.] Montefiore Med Ctr, The Bronx, NY USA.
   [Cavazzola, Leandro Totti] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.
C3 Pontificia Universidade Catolica Do Rio Grande Do Sul; Universidade do
   Grande Rio; Universidade de Sao Paulo; Montefiore Medical Center;
   Universidade Federal do Rio Grande do Sul
RP Lima, DL (通讯作者)，Montefiore Med Ctr, Dept Surg, New York, NY 10467 USA.
EM dilaurentino@gmail.com
RI Cavazzola, Leandro/G-1305-2015; L Lima, Diego/AAL-4497-2020; Kasmirski,
   Julia/KFB-2125-2024; Silveira, Carlos/PXC-4574-2026
OI Eckerdt Lech, Gabriele/0000-0002-4017-2945; L Lima,
   Diego/0000-0001-7383-1284; Kasmirski, Julia/0000-0002-7435-048X; 
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NR 30
TC 4
Z9 8
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD OCT
PY 2024
VL 48
IS 10
BP 2391
EP 2399
DI 10.1002/wjs.12336
EA SEP 2024
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J9P1X
UT WOS:001306657400001
PM 39243381
DA 2026-07-24
ER
PT J
AU Wu, CQ
   Jin, ZX
   Yang, YM
AF Wu, Chunqiao
   Jin, Zhexia
   Yang, Yongmei
TI A large forearm subcutaneous hematoma after contrast extravasation
   requires surgical managements: A case report
SO MEDICINE
LA English
DT Article
DE case report; computed tomography; contrast extravasation; debridement;
   hematoma; nursing care
AB Rationale: Large extremity hematoma can rarely happen after contrast extravasation during a contrast-enhanced computed tomography scan. Some hematomas need prompt surgical managements. Patient concerns: A 77-year-old man had acute ischemic stroke and received the thrombolytic and antiplatelet therapies. He had a contrast extravasation during the computed tomography scan and developed a large hematoma in the right forearm, despite without evidence of compartment syndrome. Diagnosis: Right forearm hematoma, status post contrast extravasation. Interventions: The patient responded poorly to the routine care with arm elevation, cold pack, and wet dressing, and was finally treated by the surgical debridement, vacuum sealing drainage, fascioplasty, and skin flap repair. Outcomes: Right forearm wound healed with a scar. Lessons: Large extremity hematoma can happen after contrast extravasation during computed tomography scan, which may require surgical treatments. Careful preparation, close monitor, and prompt managements should be applied in high-risk patients.
C1 [Wu, Chunqiao; Jin, Zhexia; Yang, Yongmei] Zhejiang Univ, Sir Run Run Show Hosp, Sch Med, Hangzhou, Peoples R China.
C3 Zhejiang University
RP Wu, CQ (通讯作者)，Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Radiol, Hangzhou 310016, Peoples R China.
EM 13747256@qq.com; jingzhexia@163.com; jamin911@126.com
CR Beecham G B., 2022, StatPearls
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NR 10
TC 2
Z9 3
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP 6
PY 2024
VL 103
IS 36
AR e39536
DI 10.1097/MD.0000000000039536
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F2I0Q
UT WOS:001308095200083
PM 39252279
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, H
   Zhang, G
   Wei, A
   Xing, H
   Han, CS
   Chang, ZQ
AF Liu, Huan
   Zhang, Ge
   Wei, An
   Xing, Hao
   Han, Changsheng
   Chang, Zhengqi
TI Effect of negative pressure wound therapy on the incidence of deep
   surgical site infections after orthopedic surgery: a meta-analysis and
   systematic review
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Review
DE Surgical site infections; Negative pressure wound therapy; Orthopedic
   procedures
ID RISK-FACTORS; FRACTURE SURGERY; HIP; DRESSINGS; INCISION; COMPLICATIONS;
   ARTHROPLASTY; PREVENTION; FIXATION
AB ObjectiveThis meta-analysis aimed to explore the impact of prophylactic negative pressure wound therapy (NPWT) on the occurrence of deep surgical site infections (SSIs) following orthopedic surgery.MethodsA systematic search was conducted across Medline, Embase, Cochrane Library, and Web of Science databases for articles concerning NPWT in patients who underwent orthopedic surgery up to May 20, 2024. Using Stata 15.0, the combined odds ratios (ORs) were calculated with either a random-effects model or a fixed-effects model, depending on the heterogeneity values.ResultsFrom a total of 440 publications, studies that utilized NPWT as the experimental group and conventional dressings as the control group were selected to analyze their impact on SSIs. Ultimately, 32 studies met the inclusion criteria. These included 12 randomized controlled trials and 20 cohort studies, involving 7454 patients, with 3533 of whom received NPWT and 3921 of whom were treated with conventional dressings. The results of the meta-analysis demonstrated that the NPWT group had a lower incidence of deep SSIs in orthopedic surgeries than did the control group [OR 0.64, 95% CI (0.52, 0.80), P = 0.0001]. Subgroup analysis indicated a notable difference for trauma surgeries [OR 0.65, 95% CI (0.50, 0.83), P = 0.001], whereas joint surgeries [OR 0.65, 95% CI (0.38, 1.12), P = 0.122] and spine surgeries [OR 0.61, 95% CI (0.27, 1.35), P = 0.221] did not show significant differences. Additionally, when examined separately according to heterogeneity, trauma surgeries exhibited a significant difference [OR 0.50, 95% CI (0.31, 0.80), P = 0.004].ConclusionThe results of our study indicate that the prophylactic use of NPWT reduces the incidence of deep SSIs following orthopedic trauma surgery when compared to the use of conventional dressings. We postulate that the prophylactic application of NPWT in patients at high risk of developing complications from bone trauma may result in improved clinical outcomes and an enhanced patient prognosis.
C1 [Liu, Huan; Zhang, Ge; Wei, An; Xing, Hao; Han, Changsheng; Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Jinan 250031, Shandong, Peoples R China.
   [Liu, Huan; Xing, Hao] Shandong Second Med Univ, Sch Clin Med, Weifang 261053, Shandong, Peoples R China.
   [Zhang, Ge; Wei, An; Han, Changsheng] Shandong Univ Tradit Chinese Med, Jinan 250355, Peoples R China.
C3 Shandong Second Medical University; Shandong University of Traditional
   Chinese Medicine
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Jinan 250031, Shandong, Peoples R China.
EM 26766771@qq.com
RI han, changsheng/HPC-6050-2023; hao, xing/ACN-7926-2022; liu,
   huan/NDS-1676-2025
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NR 75
TC 6
Z9 8
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD SEP 9
PY 2024
VL 19
IS 1
AR 555
DI 10.1186/s13018-024-05038-7
PG 13
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA F4H7E
UT WOS:001309450500002
PM 39252068
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Moellhoff, N
   Demmer, W
   Pistek, S
   Wachtel, N
   Bodenschatz, K
   Lui, LL
   Alfertshofer, M
   Frank, K
   Giunta, RE
   Ehrl, D
AF Moellhoff, Nicholas
   Demmer, Wolfram
   Pistek, Svenja
   Wachtel, Nikolaus
   Bodenschatz, Karl
   Lui, Lulin
   Alfertshofer, Michael
   Frank, Konstantin
   Giunta, Riccardo E.
   Ehrl, Denis
TI Impact of Negative Pressure Wound Therapy on Perfusion Dynamics in Free
   Latissimus Dorsi Muscle Flaps
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE microsurgery; free flap; free latissimus dorsi muscle-flap;
   microcirculation; O2C; negative pressure wound therapy (NPWT)
ID MICROSURGICAL VASCULAR ANASTOMOSES; NECK RECONSTRUCTION; COMPOSITE
   TISSUES; HEAD; TRANSPLANTATION; COMPLICATIONS; EXPERIENCE; OUTCOMES;
   SITE
AB Background: Free muscle flaps can develop significant postoperative edema and wound exudation, thereby increasing interstitial pressure and potentially compromising microcirculation. While concerns exist regarding negative pressure wound therapy (NPWT) to compress free flaps and hinder monitoring, recent studies have indicated a reduction in edema and an increase in blood flow. Objective: To compare microcirculation in free latissimus dorsi muscle (LDM) flaps dressed with and without NPWT. Methods: This retrospective cohort study analyzed prospectively collected data of patients who received free LDM flap reconstruction. Patients were separated into two groups according to management with or without NPWT. Microcirculation was evaluated continuously for up to 72 h utilizing laser doppler flowmetry and tissue spectrometry. Results: In total, n = 61 patients (26 females, 35 males) with an average age of 56.90 (17.4) years were included. NPWT was applied in 12 patients, while a regular cotton dressing was used in 49 patients. Overall, no significant differences in the number of minor and major complications were observed between groups. Both groups showed an increase in microvascular flow over the investigated time period. The flow showed higher absolute values in the NPWT group, reaching statistical significance at 12 h post-anastomosis, p = 0.038. There was a tendency for lower rHb values in the NPWT group, without reaching statistical significance. Conclusions: The presented study confirms the increase in microvascular flow after NPWT application. Whilst ensuring continuous free flap monitoring utilizing laser doppler flowmetry and spectrometry, the data further support the safety of NPWT application without risking vascular compromise due to external compression.
C1 [Moellhoff, Nicholas; Demmer, Wolfram; Pistek, Svenja; Wachtel, Nikolaus; Lui, Lulin; Alfertshofer, Michael; Frank, Konstantin; Giunta, Riccardo E.; Ehrl, Denis] Univ Hosp Munich LMU, Div Hand Plast & Aesthet Surg, D-81377 Munich, Germany.
   [Bodenschatz, Karl] Paracelsus Med Univ, Nuremberg Gen Hosp, Dept Pediat Surg & Urol, D-90419 Nurnberg, Germany.
   [Ehrl, Denis] Hosp Nuremberg, Ctr Severe Burn Injuries, Clin Plast Reconstruct & Hand Surg, D-90471 Nurnberg, Germany.
C3 University of Munich
RP Ehrl, D (通讯作者)，Univ Hosp Munich LMU, Div Hand Plast & Aesthet Surg, D-81377 Munich, Germany.; Ehrl, D (通讯作者)，Hosp Nuremberg, Ctr Severe Burn Injuries, Clin Plast Reconstruct & Hand Surg, D-90471 Nurnberg, Germany.
EM denis.ehrl@klinikum-nuernberg.de
RI ; Wachtel, Nikolaus/LRC-2273-2024; Giunta, Riccardo/JVN-5790-2024;
   Alfertshofer, Michael/ACL-5945-2022
OI Frank, Konstantin/0000-0001-6994-8877; Ehrl, Denis/0000-0001-9394-8412;
   Wachtel, Nikolaus/0000-0003-3746-7838; Alfertshofer,
   Michael/0000-0002-4892-2376
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NR 34
TC 4
Z9 4
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2024
VL 13
IS 17
AR 5261
DI 10.3390/jcm13175261
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F6P8K
UT WOS:001311026800001
PM 39274475
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Klein, R
   Desvigne, MN
   Greenstein, E
   Napolitano, RJ Jr
   Milne, C
   Speyrer, MS
   Weir, D
AF Klein, Robert
   Desvigne, Michael N.
   Greenstein, Emily
   Napolitano Jr, Ralph J.
   Milne, Catherine
   Speyrer, Marcus S.
   Weir, Dot
TI Use of Silver Collagen Oxidized Regenerated Cellulose Dressings in
   Conjunction With Negative Pressure Wound Therapy: Expert Panel Consensus
   Recommendations
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE reticulated open cell foam dressing; silver collagen dressings; wound
   healing; Delphi technique; negative pressure wound therapy; oxidized
   regenerated cellulose dressings
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   ULCERS; CARE; STANDARD; METAANALYSIS; MANAGEMENT; IMPACT
AB Background. A new indication for use of silver collagen oxidized regenerated cellulose (ORC) dressing in conjunction with negative pressure wound therapy (NPWT) and reticulated open cell foam (ROCF) dressings has recently become available. Objective. An in-person meeting with 7 health care providers (HCPs) was held to identify clinical care settings and appropriate use of silver collagen ORC dressings in conjunction with NPWT and ROCF dressings. Methods. Consensus statements were developed using a modified Delphi technique. An additional 25 HCPs completed an anonymous survey on the consensus statements. Consensus was defined as >= 80% agreement among survey respondents. Results. Use of silver collagen ORC dressings with NPWT and ROCF dressings was recommended in inpatient and outpatient health care settings. Use in traumatic wounds, surgical wounds, diabetic ulcers, venous leg ulcers, and pressure injuries/ulcers was supported. Use was not recommended in the presence of exposed unprotected organs or exposed unprotected vessels, when the potential for inadequate wound hemostasis exists, acutely ischemic wounds, third-degree burns, or surgically closed incisions, or with patient hypersensitivity to product components. Conclusions. Limited evidence exists on use of NPWT in conjunction with silver collagen ORC dressings. A panel developed 12 consensus statements detailing the recommended and contraindicated uses of NPWT in conjunction with silver collagen ORC dressings.
C1 [Klein, Robert] Univ South Carolina, Sch Med, Greenville, SC 29607 USA.
   [Klein, Robert] Prisma Hlth, Greenville, SC 29605 USA.
   [Desvigne, Michael N.] Abrazo Arrowhead Hosp & Wound Clin, Glendale, AZ USA.
   [Greenstein, Emily] Essentia Hlth Fargo, Fargo, ND USA.
   [Napolitano Jr, Ralph J.] OrthoNeuro, Columbus, OH USA.
   [Napolitano Jr, Ralph J.] Ohio Univ, Heritage Coll Osteopath Med, Athens, OH USA.
   [Milne, Catherine] Connecticut Clin Nursing Assoc LLC, Bristol, CT USA.
   [Speyrer, Marcus S.] Wound Treatment Ctr, Opelousas, LA USA.
   [Weir, Dot] Saratoga Hosp Ctr Wound Healing & Hyperbar Med, Saratoga Springs, NY USA.
C3 Prisma Health; University System of Ohio; Ohio University
RP Klein, R (通讯作者)，Univ South Carolina, Sch Med Greenville, Surg, 200C Patewood Dr,Suite 300, Greenville, SC 29615 USA.
EM robklein63@gmail.com
FX Acknowledgments: The authors thank Christopher Barrett, DPM; Saeed
   Chowdhry, MD; H. John Cooper, MD; Anthony Dardano, DO, FACS; Marcus
   Duda, MD; Amanda Estapa, NP; Elizabeth Faust, CRNP, CWOCN, CWS; Regina
   Fearmonti, MD; Luis Fernandez, MD, FACS, FASAS, FCCP, FCCM, FICS; Allen
   Gabriel, MD, FACS; Janis Harrison, RN, BSN, CWOCN; Daphne Hodges, RN,
   BSN; Luther H. Holton, MD; Ravi Karia, MD; Martha Kelso, RN, HBOT; Paul
   Kim, DPM, MS; Mary Anne Obst, RN, BSN, CCRN, CWON; Todd Shaffett, DNP,
   FNP, CWS, FACCWS, DAPWCA; Olivia Snodgrass, PA; Kerry Thibodeaux, MD,
   FACS; Casey Thomas, DO, FACOS, FACS; Colin Traynor, DPM, CWSP; Terry
   Treadwell, MD; Julie West, PA; and Phil Wrotslavsky, DPM, for their
   participation in the consensus statement survey. The authors also thank
   Ricardo Martinez, Julissa Ramos, and Julie M. Robertson (Solventum) for
   assistance with manuscript preparation and editing.
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NR 50
TC 1
Z9 1
U1 2
U2 9
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2024
VL 36
IS 8
BP 263
EP 273
DI 10.25270/wnds/24026
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA G0G5R
UT WOS:001313503500004
PM 39241767
DA 2026-07-24
ER
PT J
AU Dalmedico, MM
   Fedalto, AD
   Martins, WA
   de Carvalho, CKL
   Fernandes, BL
   Ioshii, SO
AF Dalmedico, Michel Marcos
   Fedalto, Angela do Rocio
   Martins, Waleska Alves
   de Carvalho, Chayane Karla Lucena
   Fernandes, Beatriz Luci
   Ioshii, Sergio Ossamu
TI Effectiveness of Negative Pressure Wound Therapy in Treating Diabetic
   Foot Ulcers: A Systematic Review and Meta-Analysis of Randomized
   Controlled Trials
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; EFFICACY; SAFETY
AB Background. Diabetic foot ulcers (DFUs) present devastating complications. Management of these wounds includes applying a vacuum device composed of a fenestrated tube embedded in a foam dressing and connected to a vacuum pump to collect the fluid in a vessel. Objective. To review the effectiveness of negative pressure wound therapy (NPWT) in treating DFUs and evaluate the clinical outcomes of full and partial wound healing. Methods. A systematic review and meta-analysis of randomized controlled trials was conducted after searching the PubMed, Web of Science, and Cochrane Library databases. Studies that described the use of NPWT in the management of DFUs were included and compared with different interventions for the proposed outcomes. Results. A total of 14 studies were included, 1 of which was later excluded during internal validation. Wound healing outcomes were analyzed in 2 studies, showing the superiority of total wound healing in the NPWT group. Ten studies compared the effect of different interventions on wound area reduction and 8 of these results were best with NPWT. Three studies showed clinical and statistical homogeneity (I-2 = 100%), making it possible to conduct a meta-analysis. Conclusion. Although the articles included in this systematic review have limitations regarding methodological quality and clinical heterogeneity, the results showed the potential benefit of NPWT in healing and wound area reduction. These outcomes are essential in the prevention of amputation in patients with DFU.
C1 [Dalmedico, Michel Marcos; de Carvalho, Chayane Karla Lucena; Fernandes, Beatriz Luci; Ioshii, Sergio Ossamu] Pontificia Univ Catolica Parana, Grad Program Hlth Technol, Curitiba, Brazil.
   [Fedalto, Angela do Rocio; Martins, Waleska Alves] Univ Posit, Nursing Dept, Curitiba, Brazil.
C3 Pontificia Universidade Catolica do Parana
RP Fernandes, BL (通讯作者)，Pontificia Univ Catolica Parana, Polytech Sch, Grad Program Hlth Technol, R Imaculada Conceicao 1155, BR-80320030 Curitiba, PR, Brazil.
EM beatriz.fernandes@pucpr.br
RI IOSHII, SERGIO OSSAMU/K-7490-2014; Fernandes, Beatriz/JGL-9245-2023
OI IOSHII, SERGIO OSSAMU/0000-0002-7871-4463; 
CR Atef Bayoumi AASAM, 2018, The Egyptian Journal of Hospital Medicine, V72, P4054, DOI [10.21608/ejhm.2018.9115, 10.21608/ejhm.2018.9115, DOI 10.21608/EJHM.2018.9115]
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NR 27
TC 13
Z9 16
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2024
VL 36
IS 8
BP 281
EP 289
DI 10.25270/wnds/23140
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA G0G5R
UT WOS:001313503500006
PM 39241769
DA 2026-07-24
ER
PT J
AU Gao, YL
   Liu, Y
   Hu, HY
   Gao, SH
   Zhou, JL
AF Gao, Yuling
   Liu, Yang
   Hu, Hongyu
   Gao, Shunhong
   Zhou, Junlin
TI Tibial periosteum flap combined with autologous bone grafting in the
   treatment of Gustilo-IIIB/IIIC open tibial fractures
SO OPEN MEDICINE
LA English
DT Article
DE Gustilo-IIIB/III C injury; bone-skin defect; flap; periosteal flap;
   tibial fracture
ID TRAUMA; RECONSTRUCTION
AB Purpose Gustilo IIIB/C injuries are common for tibia diaphysis fractures with high rates of nonunion, osteomyelitis, and amputation. However, the managements on tibial Gustilo IIIB/C injuries are still controversial and individual. The aim of this study is to introduce the tibial periosteum flap combined with autologous bone grafting to treat Gustilo-IIIB/IIIC injuries.Methods Sixteen Gustilo type IIIB/C tibial fracture patients who underwent tibial periosteum flaps with autologous bone grafting surgeries were retrospectively studied. In the first stage, the wound was treated with debridement and the fracture was reduced and fixed with an external fixator. After covering with vacuum sealing drainage for 7 days, the wound areas were repaired by flaps. When the flaps survived and external fixators were removed, the tibial periosteum flaps were taken with autologous bone grafting for bone defects.Results The tibia fractures were comminuted fractures with mean size of segment bone defects 3.1 +/- 1.3 cm. All the flaps survived and the wound healed in the first stage after an average of 1.5 +/- 0.6 months. The mean size of the flap was 13.2 +/- 2.8 cm x 7.3 +/- 3.1 cm. All the autografts healed in 4.5 +/- 0.7 months without infection and malunion. There was no pain in the affected limb. The weight-bearing and walking function were restored.Conclusion Tibial periosteum flap combined with autologous bone grafting is effective to treat bone-skin defect of leg with Gustilo-IIIB/IIIC injury.
C1 [Hu, Hongyu; Gao, Shunhong] Second Hosp Tangshan, Dept Hand Surg, Jianshe Rd 21, Tangshan 063000, Hebei, Peoples R China.
   [Zhou, Junlin] Capital Med Univ, Beijing Chaoyang Hosp, Gongtinan Rd 8, Beijing 100020, Peoples R China.
   [Gao, Yuling; Liu, Yang] Capital Med Univ, Beijing Chaoyang Hosp, Beijing 100020, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Gao, SH (通讯作者)，Second Hosp Tangshan, Dept Hand Surg, Jianshe Rd 21, Tangshan 063000, Hebei, Peoples R China.; Zhou, JL (通讯作者)，Capital Med Univ, Beijing Chaoyang Hosp, Gongtinan Rd 8, Beijing 100020, Peoples R China.
EM 854824553@qq.com; y0ring1996@163.com; 15532550871@163.com;
   gshdj@126.com; junlinzhou_article@outlook.com
FU Beijing Key Clinical Specialty Project
FX The corresponding author Junlin Zhou discloses receipt of the following
   financial support for the research, authorship, and publication of this
   article: Beijing Key Clinical Specialty Project.
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NR 23
TC 0
Z9 1
U1 3
U2 6
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5463
J9 OPEN MED-WARSAW
JI Open Med.
PD SEP 20
PY 2024
VL 19
IS 1
AR 20241038
DI 10.1515/med-2024-1038
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA G4D5E
UT WOS:001316165200001
PM 39308921
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tang, Y
   Ji, H
   Yan, YY
   Hu, D
   Xu, MR
   Xu, M
   Zhao, XT
   Chen, MW
AF Tang, Ying
   Ji, Hua
   Yan, Yanyan
   Hu, Die
   Xu, Murong
   Xu, Min
   Zhao, Xiaotong
   Chen, Mingwei
TI Enhancing diabetic foot ulcer healing: Impact of the regulation of the
   FUS and ILF2 RNA-binding proteins through negative pressure wound
   therapy
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE diabetic foot ulcer; negative pressure wound therapy; wound healing;
   keratinocyte; RNA-binding protein; FUS; ILF2; RNA sequencing
ID MATRIX; EPIDEMIOLOGY; EXPRESSION; CANCER; GENE; TIME
AB Diabetic foot ulcer (DFU) is a destructive complication of diabetes. Negative pressure wound therapy (NPWT) promotes DFU wound healing through an undetermined mechanism. In the present study, RNA sequencing was performed on wound granulation tissue from 3 patients with DFU before and after 1 week of NPWT. The fused in sarcoma (FUS) and interleukin enhancer binding factor 2 (ILF2) encoding RNA-binding proteins (RBPs) were screened from the sequencing data, and wound tissue samples from 24 patients with DFU were validated and analyzed before and after receiving NPWT by reverse transcription-quantitative PCR, western blotting and immunohistochemistry. In addition, in vitro and in vivo experiments were conducted to determine the effect of the expression of FUS and ILF2 on the function of human epidermal keratinocyte cells (HaCaT cells) and the healing of diabetic skin wounds. The results indicated that NPWT induced the upregulation of 101 genes and the downregulation of 98 genes in DFU wound granulation tissue. After NPWT, the expression of FUS and ILF2 was significantly upregulated (P<0.05). Pearson's correlation coefficient showed that the changes in FUS and ILF2 before and after NPWT were negatively correlated with changes in white blood cells, the neutrophil percentage, C-reactive protein, tumor necrosis factor-alpha, reactive oxygen species, lipid peroxides, matrix metalloproteinase (MMP) 2 and MMP9 (P<0.05), but positively correlated with the anti-inflammatory factor, IL-4 (P<0.01). There was also a positive correlation (P<0.05) with the 4-week ulcer healing rate. Additionally, the knockdown of FUS and ILF2 expression inhibited the proliferation and migration of HaCaT cells, while increasing cell apoptosis. In vivo, the knockdown of FUS and ILF2 significantly reduced the rate of skin wound healing in diabetic mice. The results of the present study therefore provide new insights into the mechanism by which NPWT promotes DFU wound healing. In conclusion, the RBPs, FUS and ILF2, promoted DFU wound healing by regulating the function of keratinocytes and reducing the inflammatory response and oxidative stress.
C1 [Tang, Ying; Ji, Hua; Yan, Yanyan; Hu, Die; Xu, Murong; Xu, Min; Zhao, Xiaotong; Chen, Mingwei] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
C3 Anhui Medical University
RP Zhao, XT; Chen, MW (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
EM zxt522154846@163.com; chmw1@163.com
RI ; HU, Die-hua/IAR-3636-2023; Xu, Murong/HHS-2387-2022
OI ji, hua/0000-0002-7441-7963; 
FU Natural Science Foundation of Anhui Province in China
FX Not applicable.
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NR 74
TC 3
Z9 3
U1 0
U2 15
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD NOV
PY 2024
VL 54
IS 5
AR 103
DI 10.3892/ijmm.2024.5427
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA G8T9F
UT WOS:001319305900001
PM 39301661
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Berlth, F
   Wichmann, D
   Fusco, S
   Mihaljevic, A
AF Berlth, Felix
   Wichmann, Doerte
   Fusco, Stefano
   Mihaljevic, Andre
TI Anastomotic leakage following surgical resection in the upper
   gastrointestinal tract
SO CHIRURGIE
LA German
DT Review
DE Gastrectomy; Esophagectomy; Endoscopy; Vacuum therapy; Endoluminal metal
   stents; Gastrectomy; Esophagectomy; Endoscopy; Vacuum therapy;
   Endoluminal metal stents
ID VACUUM-ASSISTED CLOSURE; THERAPY; MANAGEMENT
AB Surgical resection is the consistent component of curative treatment strategies for primary malignant diseases of the stomach and the esophagus. The placement of anastomoses for the necessary reconstruction still accounts for substantial morbidity and in the case of a failure to rescue also for mortality, especially for esophagojejunostomy and esophagogastrostomy. The diagnostics of anastomotic leakage routinely involve computed tomography and endoscopy and timely performance appears to be essential. Endoscopy can simultaneously initiate the essential treatment step. A major reason for the improvement of postoperative outcomes after resection in the upper gastrointestinal tract in the last decades is the successful and mostly endoscopically performed management of anastomotic leakage, whereby different endoscopic treatment options are now available. Endoscopic vacuum therapy has become established as the standard, normally with an endoscopic vacuum sponge technique but is also now supplemented by a combination system of vacuum sponge and stent. Furthermore, a foil-coated multiple lumen nasogastric tube represents another available option, which can possibly especially be used as a prophylactic measure. The longest established endoscopic therapy option for anastomotic leaks, the endoluminal metal stent, has been replaced as the standard by the vacuum treatment but is still used in suitable situations. Additionally, there are endoscopic suture devices that are currently only used very occasionally. Surgical revision is always available as treatment escalation but is only recommended for very early occurrences and possibly technically related anastomotic leakage and in the case of failure of endoscopic treatment. This article describes and summarizes the diagnostics and treatment of anastomotic leakages after surgical procedures of the upper gastrointestinal tract.
C1 [Berlth, Felix; Mihaljevic, Andre] Eberhard Karls Univ Tubingen, Univ Klinikum Tubingen, Klin Allgemein Viszeral & Transplantationschirurgi, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
   [Wichmann, Doerte; Fusco, Stefano] Eberhard Karls Univ Tubingen, Univ Klinikum Tubingen, Klin Gastroenterol Hepatol & Infektiol & Geriatrie, Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital
RP Berlth, F (通讯作者)，Eberhard Karls Univ Tubingen, Univ Klinikum Tubingen, Klin Allgemein Viszeral & Transplantationschirurgi, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
EM felix.berlth@med.uni-tuebingen.de
RI Fusco, Stefano/JYQ-3117-2024
OI Fusco, Stefano/0000-0001-6093-4567
CR Baum P, 2019, DTSCH ARZTEBL INT, V116, P739, DOI 10.3238/arztebl.2019.0739
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NR 28
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2731-6971
EI 2731-698X
J9 CHIRURGIE
JI Chirurgie
PD NOV
PY 2024
VL 95
IS 11
BP 871
EP 877
DI 10.1007/s00104-024-02174-y
EA SEP 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J8F3F
UT WOS:001319726600002
PM 39316181
DA 2026-07-24
ER
PT J
AU Macisaac, MF
   Wright, JM
   Halsey, JN
   Fitzgerald, RE
   Snyder, CW
   Rottgers, SA
AF Macisaac, Molly F.
   Wright, Joshua M.
   Halsey, Jordan N.
   Fitzgerald, Ryan E.
   Snyder, Christopher W.
   Rottgers, S. Alex
TI Management of Pediatric Type III Tibial Shaft Fractures
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE type III tibial fracture; open tibial shaft fracture; pediatrics;
   soft-tissue reconstruction; Gustilo type III; orthopedics
ID SOFT-TISSUE; TRAUMA; FIXATION; CHILDREN; POPULATION; SERIES; BONE
AB Background: Pediatric open tibial fractures represent a challenging subset of injuries with limited literature to guide management. For children, the epidemiology, management, and outcomes of tibial-shaft fractures have not been fully described. Methods: A retrospective analysis of the Trauma Quality Improvement Program Data Bank from 2017-2020 was used to query demographics, injury patterns, and management strategies in pediatric open tibial fractures. Fractures were compared by age group (0-5, 6-12, 13-17 years) and type (I/II vs type III). A subgroup analysis was performed on patients with type III open fractures. Results: A total of 3480 open tibial fractures were identified, 3049 were type I/II, and 431 were type III. Motor vehicle accidents (48%) were the most common mechanism of injury (P < 0.001). Subanalysis of 128 type IIIb/c tibial fractures revealed local flap reconstruction (25%) skin graft (25%), and free tissue transfer were the most common management strategies and soft-tissue coverage was achieved after 162 hours (interquartile range = 109-231). Negative pressure wound therapy was utilized in 63% of cases but used in isolation in only 23% of cases. Immediate fixation with intramedullary nailing was more frequently used in the 13-17 age group while plate fixation was more commonly used in younger age groups. Conclusions: Soft-tissue management patterns following open tibial shaft fractures mirror those seen in adult cohorts. The median time to achieve soft-tissue coverage exceeds the traditional 72-hour target advocated by Godina. Age-based variation is seen in orthopedic management of these fractures based on growth maintenance concerns.
C1 [Macisaac, Molly F.; Wright, Joshua M.; Halsey, Jordan N.; Rottgers, S. Alex] Johns Hopkins All Childrens Hosp, Div Plast & Reconstruct Surg, St Petersburg, FL USA.
   [Fitzgerald, Ryan E.] Johns Hopkins All Childrens Hosp, Div Orthoped Surg, St Petersburg, FL USA.
   [Fitzgerald, Ryan E.] Childrens Orthopaed & Scoliosis Surg Associates LL, St Petersburg, Florida, Uruguay.
   [Snyder, Christopher W.] Johns Hopkins All Childrens Hosp, Dept Pediat Surg, St Petersburg, FL USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins
   University; Johns Hopkins Medicine; Johns Hopkins University; Johns
   Hopkins Medicine
RP Rottgers, SA (通讯作者)，601 5th St South,Suite 306, St Petersburg, FL 33701 USA.
EM mmacisa1@jh.edu; dr.joshuamwright@gmail.com; jhalsey2@jhmi.edu;
   rfitzg11@jhmi.edu; csnyde21@jhmi.edu; srottge1@jhmi.edu
RI ; Halsey, Jordan/D-2545-2011
OI Wright, Joshua/0000-0003-2225-3247; MacIsaac, Molly/0000-0002-3632-4205;
   
CR Baldwin KD, 2009, J CHILD ORTHOP, V3, P199, DOI 10.1007/s11832-009-0169-6
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NR 30
TC 0
Z9 0
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2024
VL 93
IS 4
BP 501
EP 509
DI 10.1097/SAP.0000000000004102
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA H2B5Q
UT WOS:001321545200004
PM 39331748
DA 2026-07-24
ER
PT J
AU Jelinek, P
   Hrubovcak, J
   Hajovsky, R
   Velicka, J
   Pies, M
AF Jelinek, Petr
   Hrubovcak, Jan
   Hajovsky, Radovan
   Velicka, Jan
   Pies, Martin
TI Application of Closed Incision Negative Pressure Wound Therapy in
   Ventral Hernia Repair Surgery Using a Polypropylene Mesh: A Randomized
   Clinical Trial
SO MEDICINA-LITHUANIA
LA English
DT Article
DE negative pressure therapy; polypropylene mesh; randomized trial; wound
   infection; aseptic wounds; ventral hernia repair
AB Background and Objectives: Surgical site infections (SSIs) are a significant complication following ventral hernia repair, potentially leading to prolonged hospital stays and increased morbidity. This study aimed to evaluate whether closed incision negative pressure wound therapy (ciNPWT) reduces the incidence of SSI after ventral hernia repair with polypropylene mesh compared to standard wound care. Materials and Methods: A randomized study was conducted with 100 patients undergoing ventral hernia repair using a polypropylene mesh. Participants were divided into two groups: a control group (n=50), which received standard sterile gauze dressing with an iodine-based disinfectant, and an intervention group (n=50), treated with the ciNPWT system (Vivano (R) by HARTMANN) for 5 days postoperatively. The primary outcome was the incidence of SSI within one year after surgery. Secondary outcomes included the influence of factors such as age, sex, smoking status, and hernia size on SSI occurrence. The study was approved by the Ethics Committee at the University Hospital Ostrava, adhering to the ethical standards of the Helsinki Declaration. Results: The incidence of SSI was lower in the ciNPWT group compared to the standard care group (4% vs. 12%), though this difference did not reach statistical significance. No significant effect of sex or smoking status on SSI was observed. The control group had a shorter mean length of hospital stay. Larger hernias in the non-ciNPWT group were more prone to SSIs, as expected. Conclusions: Although limited by a small sample size, the findings suggest that ciNPWT may be associated with a reduced rate of SSI following ventral hernia repair. Further studies with larger populations are needed to confirm these results.
C1 [Jelinek, Petr; Hrubovcak, Jan] Univ Hosp Ostrava, Dept Surg, 17 Listopadu 1790-5, Ostrava 70800, Czech Republic.
   [Jelinek, Petr; Hrubovcak, Jan] Univ Ostrava, Fac Med, Dept Surg Studies, Syllabova 19, Ostrava 70300, Czech Republic.
   [Hajovsky, Radovan; Velicka, Jan; Pies, Martin] VSB Tech Univ Ostrava, Fac Elect Engn & Comp Sci, Dept Cybernet & Biomed Engn, 17 Listopadu 2172-15, Ostrava 70800, Czech Republic.
C3 University Hospital Ostrava; University of Ostrava; Technical University
   of Ostrava
RP Jelinek, P (通讯作者)，Univ Hosp Ostrava, Dept Surg, 17 Listopadu 1790-5, Ostrava 70800, Czech Republic.; Jelinek, P (通讯作者)，Univ Ostrava, Fac Med, Dept Surg Studies, Syllabova 19, Ostrava 70300, Czech Republic.; Pies, M (通讯作者)，VSB Tech Univ Ostrava, Fac Elect Engn & Comp Sci, Dept Cybernet & Biomed Engn, 17 Listopadu 2172-15, Ostrava 70800, Czech Republic.
EM petr.jelinek@fno.cz; jan.hrubovcak@fno.cz; radovan.hajovsky@vsb.cz;
   jan.velicka@vsb.cz; martin.pies@vsb.cz
RI ; Pies, Martin/K-1249-2013; Velicka, Jan/HTR-2050-2023
OI Jelinek, Petr/0000-0002-3988-024X; Pies, Martin/0000-0001-8029-1669;
   Hrubovcak, jan/0009-0002-0993-2472; Hajovsky,
   Radovan/0000-0001-7609-1787; Velicka, Jan/0000-0003-1893-8729
FU Ministry of Health of the Czech Republic; Ministry of Education of the
   Czech Republic [SP2024/021]; European Union under the REFRESH - Research
   Excellence For REgion Sustainability and High-tech Industries
   [CZ.10.03.01/00/22_003/0000048];  [01/RVO-FNOs/2021]
FX Supported by the project Institutional support of the Ministry of Health
   of the Czech Republic (01/RVO-FNOs/2021). This article was supported by
   the Ministry of Education of the Czech Republic (Project No.
   SP2024/021). This article was co-funded with the financial support of
   the European Union under the REFRESH - Research Excellence For REgion
   Sustainability and High-tech Industries project number
   CZ.10.03.01/00/22_003/0000048 via the Operational Programme Just
   Transition.
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NR 13
TC 1
Z9 1
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD SEP
PY 2024
VL 60
IS 9
AR 1548
DI 10.3390/medicina60091548
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA H5P9I
UT WOS:001323970700001
PM 39336589
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Clifford, S
   Kelsom, C
   Alicuben, ET
AF Clifford, Sarah
   Kelsom, Corey
   Alicuben, Evan T.
TI Endoscopic Management of Iatrogenic Perforations
SO THORACIC SURGERY CLINICS
LA English
DT Article
DE Esophageal perforation; Stent; Clip; Endoscopic vacuum therapy
ID VACUUM-ASSISTED CLOSURE; ESOPHAGEAL PERFORATIONS; MULTICENTER
   EXPERIENCE; THERAPY; STENT; DEVICE; LEAKS; DEFECTS; OPTIONS; REPAIR
C1 [Clifford, Sarah; Kelsom, Corey; Alicuben, Evan T.] Univ Pittsburgh, Med Ctr, Dept Cardiothorac Surg, Div Thorac Surg, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Alicuben, ET (通讯作者)，5200 Ctr Ave,Suite 715, Pittsburgh, PA 15232 USA.
EM alicubenet@upmc.edu
RI Alicuben, Evan/OAJ-8003-2025
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   Jung CFM, 2021, DIGESTION, V102, P469, DOI 10.1159/000506101
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   Khaitan PG, 2022, J GASTROINTEST SURG, V26, P2606, DOI 10.1007/s11605-022-05454-2
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   Lampridis S, 2020, J THORAC DIS, V12, P2724, DOI 10.21037/jtd-19-4096
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   Ong GKB, 2018, ANN THORAC SURG, V106, P830, DOI 10.1016/j.athoracsur.2018.05.010
   Qadeer MA, 2007, GASTROINTEST ENDOSC, V66, P605, DOI 10.1016/j.gie.2007.03.1028
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NR 46
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1547-4127
EI 1558-5069
J9 THORAC SURG CLIN
JI Thorac. Surg. Clin.
PD NOV
PY 2024
VL 34
IS 4
BP 331
EP 339
DI 10.1016/j.thorsurg.2024.07.001
EA SEP 2024
PG 9
WC Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System; Surgery
GA H7F3E
UT WOS:001325056800001
PM 39332858
DA 2026-07-24
ER
PT J
AU Castrejón, EBM
   Reina-Bautista, E
   Ventura-Gómez, ST
   Cisneros, AM
   Ramos, JAJ
   Durán, MAS
   Ventura, JA
   Valencia-Ledezma, OE
   Frias-De-León, MG
   Salazar, EG
   Castro-Fuentes, CA
AF Castrejon, Esteban Bladimir Martinez
   Reina-Bautista, Erika
   Ventura-Gomez, Sandra Tania
   Cisneros, Araceli Maldonado
   Ramos, Jessica Alejandra Juarez
   Duran, Miguel Alejandro Sanchez
   Ventura, Jesus Aguilar
   Valencia-Ledezma, Omar Esteban
   Frias-De-Leon, Maria Guadalupe
   Salazar, Eduardo Garcia
   Castro-Fuentes, Carlos Alberto
TI Empyema Necessitatis Caused by Prevotella melaninogenica and
   Dialister pneumosintes Resolved with Vacuum-Assisted Closure
   System: A Case Report
SO MICROORGANISMS
LA English
DT Article
DE empyema necessitatis; Prevotella; Dialister; VAC; case report
ID RESISTANT STAPHYLOCOCCUS-AUREUS; THERAPY
AB Empyema necessitatis is a rare complication of an untreated or inadequately controlled empyema. We present the case of an 11-year-old female adolescent living in precarious conditions, overcrowding, incomplete vaccinations, irregular dental hygiene, and no significant family or personal medical history. The patient started with symptoms one week prior to her hospitalization, presenting a persistent sporadic dry cough, and was later diagnosed with complicated pneumonia, resulting in the placement of an endopleural tube. Vancomycin (40 mg/kg/day) and ceftriaxone (75 mg/kg/day) were administered. However, the clinical evolution was unfavorable, with fever and respiratory distress, so a right jugular catheter was placed. The CT scan showed a loculated collection that occupied the entire right lung parenchyma and pneumothorax at the right upper lobe level. After four days of treatment, the patient still presented purulent drainage with persistent right pleural effusion syndrome. P. melaninogenica and D. pneumosintes were identified from the purulent collection on the upper right lobe, so the antimicrobial treatment was adapted to a glycopeptide, Teicoplanin, at a weight-based dosing of 6 mg/kg/day and Metronidazole at a weight-based dosing of 30 mg/kg/day. In addition, VAC therapy was used for 26 days with favorable resolution.
C1 [Castrejon, Esteban Bladimir Martinez; Ventura-Gomez, Sandra Tania; Cisneros, Araceli Maldonado; Ramos, Jessica Alejandra Juarez; Duran, Miguel Alejandro Sanchez; Ventura, Jesus Aguilar] Hosp Reg Alta Especial Ixtapaluca, Pediat Intens Care Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.
   [Reina-Bautista, Erika] Hosp Reg Alta Especial Ixtapaluca, Pediat Infectol Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.
   [Valencia-Ledezma, Omar Esteban; Castro-Fuentes, Carlos Alberto] Hosp Reg Alta Especial Ixtapaluca, Res Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.
   [Frias-De-Leon, Maria Guadalupe; Salazar, Eduardo Garcia] Hosp Reg Alta Especial Ixtapaluca, Biomed Res Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.
RP Ventura-Gómez, ST (通讯作者)，Hosp Reg Alta Especial Ixtapaluca, Pediat Intens Care Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.; Castro-Fuentes, CA (通讯作者)，Hosp Reg Alta Especial Ixtapaluca, Res Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.
EM estebanmartinezcastrejon05@gmail.com; erika.reinab@gmail.com;
   venturagst@gmail.com; aisely_girl@hotmail.com; alehu.ice10@gmail.com;
   dr_miguelsanchez@hotmail.com; jesus.aguilar.v@hotmail.com;
   esteban84valencia@gmail.com; magpefrias@gmail.com;
   eduardogs01@hotmail.com; castrofuenca@gmail.com
RI ; Castro-Fuentes, Carlos Alberto/NFS-7962-2025
OI Frías De León, María Guadalupe/0000-0002-3160-8698; Castro-Fuentes,
   Carlos Alberto/0000-0002-1277-7170; SANCHEZ DURAN, MIGUEL
   ALEJANO/0009-0008-4890-4179; VALENCIA-LEDEZMA, OMAR
   ESTEBAN/0000-0002-7239-7946
CR Ahmed SI, 2007, AM J MED SCI, V333, P106, DOI 10.1097/00000441-200702000-00007
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NR 23
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD SEP
PY 2024
VL 12
IS 9
AR 1881
DI 10.3390/microorganisms12091881
PG 8
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA H9J6U
UT WOS:001326528000001
PM 39338554
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Faurschou, IK
   Sorensen, MJ
   Pedersen, AG
   Rasmussen, SL
   Erichsen, R
   Haas, S
AF Faurschou, Ida Kaad
   Sorensen, Marlene Julia
   Pedersen, Allan Gorm
   Rasmussen, Simon Ladefoged
   Erichsen, Rune
   Haas, Susanne
TI Closed-incision negative-pressure wound therapy after Bascom's cleft
   lift surgery for pilonidal sinus disease: A randomized study comparing
   healing
SO COLORECTAL DISEASE
LA English
DT Article
DE Bascom cleft lift; ciNPT; cleft lift surgery; negative-pressure wound
   therapy; non-healing wound; pilonidal disease; pilonidal sinus;
   pilonidal sinus disease; pilonidal surgery; recurrent pilonidal disease;
   surgical flaps; vacuum-assisted closure
AB AimDespite favourable outcomes in recurrence after off-midline closure techniques in pilonidal surgery, between 18% and 40% of patients suffer from prolonged postoperative wound healing. The aim of this work was to investigate if closed-incision negative-pressure wound therapy (NPWT) promotes wound healing after Bascom's cleft lift (BCL) surgery for complicated pilonidal sinus disease compared with conventional drainage and dressing.MethodPatients were randomized to either NPWT for 4-7 days or loop-vessel drain for 24 h and a dry dressing postoperatively. Healing was evaluated by a wound care nurse blinded for randomization at 2 and 12 weeks postoperatively (primary endpoint). Healing was defined as one or no closing defects of <= 5 mm and with no undermining.ResultsAlthough we had wanted to recruit 200 patients, the study was terminated at 118 patients (NPWT group, n = 60; control group, n = 58) after interim analysis. Patients were comparable by age, sex, body mass index, previous smoking status and indication for BCL surgery. At 2 weeks 12% of patients were healed in both the NPWT and control groups [risk difference = 0.00(95% CI -0.12 to 0.11), p = 1.00]. After 12 weeks, 68% of patients were healed in the NPWT group and 72% in the control group [risk difference = -0.03 (95% CI 0.19 to 0.13), p = 0.82]. There was no significant difference in pain experienced postsurgery. In a symptom-based questionnaire, the control group reported self-esteem to be less affected (p = 0.015).ConclusionClosed-incision negative-pressure wound therapy did not significantly improve healing after BCL surgery for complicated pilonidal sinus disease.
C1 [Faurschou, Ida Kaad; Erichsen, Rune; Haas, Susanne] Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
   [Faurschou, Ida Kaad; Sorensen, Marlene Julia; Rasmussen, Simon Ladefoged; Erichsen, Rune; Haas, Susanne] Randers Reg Hosp, Pilonidal Dis Ctr, Dept Surg, Skovlyvej 17,Indgang F F1, DK-8930 Randers, Denmark.
   [Pedersen, Allan Gorm] Horsens Reg Hosp, Dept Surg, Horsens, Denmark.
   [Erichsen, Rune] Aarhus Univ, Dept Clin Epidemiol, Aarhus, Denmark.
   [Erichsen, Rune] Aarhus Univ Hosp, Aarhus, Denmark.
C3 Aarhus University; Aarhus University; Aarhus University; Aarhus
   University
RP Faurschou, IK (通讯作者)，Randers Reg Hosp, Pilonidal Dis Ctr, Dept Surg, Skovlyvej 17,Indgang F F1, DK-8930 Randers, Denmark.
EM idafau@rm.dk
OI Erichsen, Rune/0000-0001-9398-9185; Rasmussen, Simon
   Ladefoged/0000-0002-2560-4877; Faurschou, Ida Kaad/0000-0001-9760-5345
FU Pilonidal Disease Center at Randers Regional Hospital, Denmark
FX This study was initiated by the Pilonidal Disease Center at Randers
   Regional Hospital, Denmark. The authors of the study did not receive
   payment; however, the Prevena (TM) NPWT systems were sponsored by the
   producer of the products, Acility.
CR Banasiewicz Tomasz, 2013, Pol Przegl Chir, V85, P371, DOI 10.2478/pjs-2013-0056
   Bascom J, 2002, ARCH SURG-CHICAGO, V137, P1146, DOI 10.1001/archsurg.137.10.1146
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   Wysocki AP, 2018, V4, P5
   Yoong S., 2020, TOBACCO POSTSURGICAL
NR 23
TC 3
Z9 4
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JAN
PY 2025
VL 27
IS 1
AR e17198
DI 10.1111/codi.17198
EA OCT 2024
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA S2E0Z
UT WOS:001326639900001
PM 39370557
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hong, OY
   Yang, J
   Wan, HY
   Huang, JL
   Yin, YF
AF Hong, Ouyang
   Yang, Jing
   Wan, Haiyan
   Huang, Jiali
   Yin, Yifan
TI Effects of different treatment measures on the efficacy of diabetic foot
   ulcers: a network meta-analysis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE diabetic foot ulcers; ultrasonic debridement; negative pressure wound
   therapy; stem cells; hyperbaric oxygen therapy; topical oxygen therapy;
   platelet-rich plasma; acellular dermal matrix
ID PLATELET-RICH PLASMA; PRESSURE WOUND THERAPY; HYPERBARIC-OXYGEN THERAPY;
   VACUUM-ASSISTED CLOSURE; CONTROLLED-TRIAL; CLINICAL-TRIAL; DOUBLE-BLIND;
   STANDARD; SAFETY; CELLS
AB Introduction Through a network meta-analysis, we compared different treatment measures for patients with diabetic foot ulcers (DFU), assessing their impact on the healing of DFU and ranking them accordingly.Methods We searched the PubMed, the China National Knowledge Infrastructure (CNKI), Embase, the WanFang and the WeiPu database. The retrieval time was from database establishment to January 2024, and retrieval entailed subject and free words. Randomized controlled trials (RCTs) with different treatment measures for DFU were included. Data extraction and evaluation were based on the PRISMA guidelines. Meta-analyses using pairwise and network methods were employed to compare and rank the effectiveness of different treatments for DFU.Results Ultimately, we included 57 RCTs involving a total of 4,826 patients with DFU. When it comes to ulcer healing rates, compared to standard of care(SOC),platelet-rich plasma(PRP), hyperbaric oxygen therapy(HBOT), topical oxygen therapy(TOT), acellular dermal matrix(ADM), and stem cells(SCs) in both direct meta-analysis(DMA) and network meta-analysis(NMA) can effectively increase the complete healing rate. For Scs+PRP, a statistically significant improvement was only observed in the NMA. Moreover, when compared to the negative pressure wound therapy(NPWT) group, the PRP+NPWT group was more effective in promoting the complete healing of ulcers. In terms of promoting the reduction of ulcer area, no statistical differences were observed among various treatment measures. When it comes to ulcer healing time, both PRP and NPWT can effectively shorten the healing time compared to SOC. Furthermore, when compared to the NPWT group, the combined treatment of PRP and ultrasonic debridement(UD) with NPWT is more effective in reducing healing time. In terms of amputation rates and adverse reactions, the PRP group effectively reduced the amputation rate and adverse reactions for patients with DFU. Additionally, compared to the NPWT group, the combined treatment of PRP and UD with NPWT reduced the incidence of adverse reactions. However, no significant differences were observed among other treatment measures in terms of amputation rates and adverse reactions. The ranking results showed that the efficacy of PRP+NPWT and UD+NPWT in promoting ulcer healing, reducing ulcer area, shortening healing time, decreasing amputation rates and adverse reactions is superior to that of the alone PRP group, NPWT group, and UD group. Conversely, the SOC group demonstrates the least effective performance in all aspects.Conclusion Due to the particularity of the wound of DFU, the standard of care is not effective, but the new treatment scheme has a remarkable effect in many aspects. And the treatment of DFU is not a single choice, combined with a variety of methods often achieve better efficacy, and will not bring more adverse reactions.
C1 [Hong, Ouyang; Yang, Jing; Wan, Haiyan; Huang, Jiali] Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Clin Med Coll 2,Affiliated Peoples Hosp 5, Geriatr Dis Inst Chengdu,Dept Endocrine & Metab, Chengdu, Peoples R China.
   [Yin, Yifan] Chengdu Third Peoples Hosp, Dept Nephrol, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Hong, OY; Yang, J; Wan, HY (通讯作者)，Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Clin Med Coll 2,Affiliated Peoples Hosp 5, Geriatr Dis Inst Chengdu,Dept Endocrine & Metab, Chengdu, Peoples R China.
EM 1668846734@qq.com; yjwyynfm@163.com; 54336623@qq.com
FU Project of Sichuan Medical Association "The effect of Compound Huangbai
   Liquid combined with Dragon blood exhaustive application on chronic
   diabetic lower limb ulcer" [Q20052]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This project is
   supported by the project of Sichuan Medical Association "The effect of
   Compound Huangbai Liquid combined with Dragon blood exhaustive
   application on chronic diabetic lower limb ulcer"(No. Q20052).
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NR 122
TC 15
Z9 17
U1 2
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 23
PY 2024
VL 15
AR 1452192
DI 10.3389/fendo.2024.1452192
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA H9R6A
UT WOS:001326734400001
PM 39377075
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, R
   Na, H
   Cheng, SW
   Zeng, YF
AF Wang, Rong
   Na, Han
   Cheng, Shaowen
   Zeng, Yunfu
TI Effect of Compound Xuejie Powder combined with negative pressure wound
   therapy on diabetic foot ulcers and blood flow in the dorsal foot artery
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Compound dried blood powder; negative pressure wound therapy; diabetic
   foot; ulcer; dorsal foot artery blood flow; local inflammation
AB Objective: To observe the therapeutic effect of Compound Xuejie Powder combined with negative pressure wound therapy (NPWT) on diabetic foot ulcers and its influence on the blood flow of the dorsal artery in the foot. Methods: A total of 103 patients with diabetic foot ulcers, admitted to our hospital between February 2021 and March 2023, were included in this study. The control group was given NPWT on the basis of conventional treatment such as controlling blood sugar and blood pressure, anti-infection therapy and improving blood circulation, while the observation group was given Compound Xuejie Powder combined with NPWT on the basis of conventional treatment. The two groups were compared in terms of granulation tissue coverage and thickness, wound healing time, levels of inflammatory factors related to Notch signaling pathway in wound exudation, serum angiogenesis factors, and dorsal foot artery blood flow. Results: Before treatment, there were no significant differences between the two groups in the levels of inflammatory factors related to the Notch signaling pathway in wound exudates or serum angiogenesis factors (all P>0.05). After treatment, vascular endothelial growth factor (VEGF) level increased, while the levels of TNF-alpha, IL-1 beta, IL-6, IL-17 and chemoattractant factor (pigment epithelium-derived factor, PEDF) decreased in both groups, an these alterations in the observation group were more pronounced compared to the control group (all P<0.05). There was no significant difference in dorsal foot artery blood flow before treatment (all P>0.05); however, Vm, PI, RI and vascular diameter were notably increased in both groups after the treatment, with more pronounced improvements noticed in the observation group (all P<0.05). The total effective rate, granulation tissue coverage rate, and granulation tissue thickness were significantly higher while wound healing time was significantly shorter in the observation group compared to the control group (all P<0.05). Conclusion: In the treatment of diabetic foot ulcers, Compound Xuejie Powder combined with NPWT can effectively inhibit local inflammation, improve the blood flow of the dorsal foot artery and promote ulcer healing.
C1 [Wang, Rong; Cheng, Shaowen; Zeng, Yunfu] Hainan Med Univ, Affiliated Hosp 1, Dept Wound Repair, 31 Longhua Rd, Haikou 570100, Hainan, Peoples R China.
   [Na, Han] Hainan Med Univ, Affiliated Hosp 1, Dept Endocrinol, Haikou 570102, Hainan, Peoples R China.
C3 Hainan Medical University; Hainan Medical University
RP Zeng, YF (通讯作者)，Hainan Med Univ, Affiliated Hosp 1, Dept Wound Repair, 31 Longhua Rd, Haikou 570100, Hainan, Peoples R China.
EM yunfuzeng84090@163.com
FU Hainan Provincial Natural Science Foundation [822 QN463, 822MS174];
   Hainan Province Health Industry Research Project [22A200051]
FX This work was supported by the Hainan Provincial Natural Science
   Foundation (822 QN463, 822MS174) and Hainan Province Health Industry
   Research Project (22A200051) .
CR Andriankaja OM, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11102770
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NR 21
TC 1
Z9 1
U1 2
U2 10
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2024
VL 16
IS 9
BP 4996
EP 5003
DI 10.62347/XSXY3749
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA I0I0Z
UT WOS:001327170100065
PM 39398571
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Tahir, S
   Parvin, F
   Wang, M
   Deva, AK
   Vickery, K
   Hu, HH
AF Tahir, Shamaila
   Parvin, Farhana
   Wang, Matthew
   Deva, Anand K.
   Vickery, Karen
   Hu, Honghua
TI The efficacy of antimicrobial solutions against multispecies bacterial
   biofilm with or without negative pressure wound therapy in an in vitro
   wound model
SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
LA English
DT Article
ID RAPID IDENTIFICATION; SITU HYBRIDIZATION
AB Objectives: Biofilm is the major challenge in chronic wound management. Instilling a wound cleansing solution aids in wound bed cleaning and infectious pathogen elimination. Negative pressure wound therapy (NPWT) improves the wound-healing process. This study investigated the efficacy of two antimicrobials (Vashe Wound Cleanser and Prontosan Wound Irrigation Solution) against a multispecies bacterial biofilm with or without NPWT in an in vitro wound model. Methods; A mixed multispecies biofilm containing Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pyogenes, and Acinetobacter baumannii was developed and verified by scanning electron microscopy and fluorescent in situ hybridization. The efficacy of Vashe and Prontosan against multispecies biofilm with or without NPWT was evaluated by colony-forming unit (cfu) of each species and total bacterial number, and visually confirmed by live/dead stain and confocal microscopy. Results: Prontosan reduced biofilm cell numbers significantly: 6 instils over 24 h resulting in 3.86 +/- 0.14 cfu log10 reduction without NPWT and 4.75 +/- 0.13 cfu log10 reduction combined with NPWT (P < 0.01) and 12 instils over 48 h resulting in 5.24 +/- 0.11 cfu log10 reduction without NPWT and biofilm eradication with NPWT (P < 0.001). NPWT alone or combined with Vashe failed to reduce multispecies biofilm numbers significantly over 24 or 48 h. Conclusions: Prontosan significantly reduced biofilm cell numbers, with better efficacy over 48 than 24 h, emphasizing the necessity for persistent and robust treatment. NPWT enhanced the effectiveness of Prontosan instillation. However, NPWT alone or combined with Vashe showed limited efficacy and difficulty when combating the multispecies biofilm in vitro.
C1 [Tahir, Shamaila; Parvin, Farhana; Deva, Anand K.; Vickery, Karen; Hu, Honghua] Macquarie Univ, Macquarie Med Sch, Sydney, NSW 2109, Australia.
   [Wang, Matthew] Univ New South Wales, Fac Med & Hlth, Sydney, NSW 2052, Australia.
   [Hu, Honghua] Zhejiang Univ, Innovat Ctr Translat Pharm, Jinhua Inst, Jinhua 321016, Peoples R China.
   [Hu, Honghua] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China.
C3 Macquarie University; University of New South Wales Sydney; Zhejiang
   University; Zhejiang University
RP Hu, HH (通讯作者)，Macquarie Univ, Macquarie Med Sch, Sydney, NSW 2109, Australia.; Hu, HH (通讯作者)，Zhejiang Univ, Innovat Ctr Translat Pharm, Jinhua Inst, Jinhua 321016, Peoples R China.; Hu, HH (通讯作者)，Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China.
EM honghuahu@zju.edu.cn
RI ; Hu, Honghua/K-4525-2012
OI Vickery, Karen/0000-0003-0998-1370; Deva, Anand/0000-0002-0314-7177; 
FU KCI Medical Australia Pty Ltd.
FX This research was funded by KCI Medical Australia Pty Ltd. The funders
   had no role in the study design; data collection, analyses, and
   interpretation; manuscript preparation; or decision on results to
   publish.
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   Tahir S, 2018, MATERIALS, V11, DOI 10.3390/ma11050811
   Tavares A, 2008, J CLIN MICROBIOL, V46, P3097, DOI 10.1128/JCM.00910-08
   Tingting S, 2023, FRONT SURG, V10, DOI 10.3389/fsurg.2023.1080838
   Valente PMDS, 2016, INT WOUND J, V13, P130, DOI 10.1111/iwj.12248
   Wang GQ, 2018, ANTON LEEUW INT J G, V111, P1557, DOI 10.1007/s10482-018-1045-5
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NR 22
TC 0
Z9 2
U1 1
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0305-7453
EI 1460-2091
J9 J ANTIMICROB CHEMOTH
JI J. Antimicrob. Chemother.
PD OCT 3
PY 2024
VL 79
IS 12
BP 3178
EP 3185
DI 10.1093/jac/dkae338
EA OCT 2024
PG 8
WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy
GA P0Y2Q
UT WOS:001328335800001
PM 39361487
DA 2026-07-24
ER
PT J
AU Dimofte, F
   Dimofte, C
   Ungurianu, S
   Serban, C
   Tocu, G
   Cârneciu, N
   Filip, I
   Bezman, L
   Fulga, A
   Tutunaru, D
   Abdulan, IM
   Ciuntu, BM
   Mihailov, R
   Vasilescu, AM
   Firescu, D
AF Dimofte, Florentin
   Dimofte, Cristina
   Ungurianu, Sorin
   Serban, Cristina
   Tocu, George
   Carneciu, Nicoleta
   Filip, Iulia
   Bezman, Laura
   Fulga, Ana
   Tutunaru, Dana
   Abdulan, Irina Mihaela
   Ciuntu, Bogdan Mihnea
   Mihailov, Raul
   Vasilescu, Alin Mihai
   Firescu, Dorel
TI The Management of Wound Healing in Infections after Hip Arthoplasty
   Using Stimulan and Negative Pressure Wound Therapy
SO DIAGNOSTICS
LA English
DT Article
DE hip arthroplasty; infection; biocomposite; negative pressure wound
   therapy
ID CALCIUM-SULFATE BEADS; ANTIBIOTIC DELIVERY; ARTHROPLASTY; OSTEOMYELITIS;
   REVISION; SERIES; RISK
AB Background: medical teams continue to face challenges with infections following hip replacement surgery, whether they occur shortly after the procedure or months or years later. Certain medical conditions like diabetes, rheumatoid arthritis, and obesity are risk factors that make patients more susceptible to infections. Traditional intervention methods such as DAIR, one-step, or two-step procedures are being enhanced and refined to ensure quicker and more effective treatment. Some cases present particularly difficult challenges, featuring persistent fistulas and unpredictable responses to treatment. Methods: in our article, we share two unique cases, detailing their histories, progressions, and treatment decisions. We explore the use of antibiotic-impregnated calcium biocomposite as a local adjuvant therapy and the application of negative pressure therapy to expedite healing. The system of NWPT has seen widespread uptake and is now implemented routinely for open wounds, such as open fractures, fasciotomies, ulcers, and infected wounds. Results: our findings demonstrate that surgical debridement and calcium sulfate bead insertion successfully treat bone and joint infections without causing any side effects or complications. As a particularity, in the first case, we encountered the exteriorization of Stimulan pearls after surgery, without other complications related to the biocomposite. Conclusions: we have found that NPWT is a beneficial tool in managing complex wounds in both acute and chronic stages, after the infection is cured, reducing the need for frequent dressing changes, shortening hospital stays, and enhancing patient comfort.
C1 [Dimofte, Florentin; Serban, Cristina; Tocu, George; Carneciu, Nicoleta; Filip, Iulia] St Apostol Andrei Cty Emergency Clin Hosp, Gen Surg Clin, Galati 800578, Romania.
   [Dimofte, Florentin; Ungurianu, Sorin; Fulga, Ana] Dunarea de Jos Univ Galati, Fac Med, Dept Morphol & Funct Sci, Galati 800008, Romania.
   [Dimofte, Cristina] St John Emergency Children Hosp, Dept Radiol, Str Gheorghe Asachi 2, Galati 800487, Romania.
   [Serban, Cristina; Filip, Iulia; Mihailov, Raul; Firescu, Dorel] Fac Med Dunarea de Jos, Dept Gen Surg, Galati 800008, Romania.
   [Tocu, George; Tutunaru, Dana] Fac Med Dunarea de Jos, Dept Lab Med, Galati 800008, Romania.
   [Carneciu, Nicoleta; Bezman, Laura] Fac Med Dunarea de Jos, Dept Ophtalmol, Galati 800008, Romania.
   [Abdulan, Irina Mihaela] Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
   [Ciuntu, Bogdan Mihnea; Vasilescu, Alin Mihai] Grigore T Popa Univ Med & Pharm, Dept Gen Surg, Iasi 700115, Romania.
C3 Dunarea De Jos University Galati; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy
RP Abdulan, IM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.; Ciuntu, BM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Gen Surg, Iasi 700115, Romania.
EM florentin.dimofte@ugal.ro; cristina.dimofte90@yahoo.com;
   sorinungurianu@yahoo.com; cristina.serban@ugal.ro; george.tocu@ugal.ro;
   nicoleta.carneciu@ugal.ro; iulia.filip@ugal.ro; laura.bezman@ugal.ro;
   ana.fulgaa@gmail.com; dana_tutunaru_cmgl@yahoo.com;
   irina.abdulan@yahoo.com; bogdanmciuntu@yahoo.com; raul.mihailov@ugal.ro;
   alin.vasilescu@umfiasi.ro; dorelfirescu@yahoo.com
RI Dimofte, Florentin/JXY-0006-2024; Fulga, Ana/AAE-3197-2022; Abdulan,
   Irina/AAA-3089-2020; /AAH-9888-2019; Cârneciu, Nicoleta/IAR-2188-2023;
   Ciuntu, Bogdan/MTF-9477-2025; Firescu, Dorel/AAB-2808-2019; Țocu,
   George/LRB-7068-2024; Vasilescu, Alin Mihai/HPE-4046-2023; Raul,
   Mihailov/IQU-7822-2023
OI Firescu, Dorel/0009-0002-0133-470X; Țocu, George/0000-0002-0953-4274;
   Vasilescu, Alin Mihai/0000-0002-9865-5114; Bezman,
   Laura/0000-0002-2327-1220; Raul, Mihailov/0000-0001-7081-9490
CR Ailaney N, 2021, J ARTHROPLASTY, V36, P2402, DOI 10.1016/j.arth.2020.11.039
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NR 29
TC 0
Z9 0
U1 2
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD OCT
PY 2024
VL 14
IS 19
AR 2206
DI 10.3390/diagnostics14192206
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA I7A3U
UT WOS:001331743200001
PM 39410610
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Alipouriani, A
   Erozkan, K
   Schabl, L
   Sancheti, H
   Sebastian, S
   Wong, SY
   Tozer, P
   Cohen, BL
   Holubar, SD
AF Alipouriani, Ali
   Erozkan, Kamil
   Schabl, Lucas
   Sancheti, Himani
   Sebastian, Shaji
   Wong, Serre-Yu
   Tozer, Phil
   Cohen, Benjamin L.
   Holubar, Stefan D.
TI TOpClass Class 4 Perineal Crohn's Disease: A Systematic Review and
   Meta-analysis of Perineal Wound Complication After Proctectomy in
   Crohn's Patients
SO INFLAMMATORY BOWEL DISEASES
LA English
DT Review
DE Crohn's disease; perianal wound; wound healing; TOpClass Consortium;
   perineal Crohn's disease
ID RISK REDUCTION STRATEGIES; SINUS; MANAGEMENT; PROCTOCOLECTOMY
AB Background Nonhealing perineal wounds have been reported to be common after proctectomy for Crohn's disease (CD). We performed a systematic review and meta-analysis of perineal wound healing after proctectomy for CD and assessed the risk factors for nonhealing.Methods A comprehensive literature search was conducted in PubMed, Embase, and Scopus databases from 2010 to 2023, and articles reporting perineal wound healing rates after proctectomy for CD were included. Data on study characteristics and proportion of healed wounds, and risk factors, were extracted. Random-effects meta-analysis was performed to estimate the pooled proportion and 95% CIs using the "meta" package in R. Heterogeneity was assessed using the I2 statistic.Results We identified 501 articles, of which 252 remained after de-duplication. After screening, 4 retrospective cohort studies involving 333 patients were included. Across the 4 studies, the pooled proportion of completely healed perineal wounds at 6 months was 65% (95% CI 52%-80%), and 70% (95% CI 60%-83%) at 12 months. Significant heterogeneity was found between studies (I2 = 86% at 6 months). Three studies examined risk factors for impaired healing after proctectomy. One study identified preoperative perineal sepsis as the only independent factor associated with impaired healing (P = .001) on multivariable analysis. In 1 study, male sex, shorter time from diversion to proctectomy, and higher preoperative C-reactive protein levels were all associated with delayed healing in univariate analysis. Another study found that close rectal dissection was associated with significantly lower healing rates than total mesorectal excision (P = .01). Prior use of tumor necrosis factor inhibitors was not associated with wound healing outcomes.Conclusions This meta-analysis revealed complete perineal healing in only 70% of patients 12 months after proctectomy for CD. This highlights knowledge gaps, including the identification of modifiable risk factors and methods for preventing or as rescue therapy, such as vacuum-assisted closure and flap reconstruction, for nonhealing perineal wounds after proctectomy for CD. Poor perineal wound healing outcomes are likely related to imperfectly understood underlying inflammatory dysregulation and systemically impaired wound healing in patients with CD.
   Meta-analysis of perineal healing after proctectomy for Crohn's revealed only 70% of patients at 12 months; the only independent risk factor was preoperative perineal sepsis; biologics did not affect healing. This highlights knowledge gaps, including best practices for prevention and treatment.
C1 [Alipouriani, Ali; Erozkan, Kamil; Schabl, Lucas; Sancheti, Himani; Holubar, Stefan D.] Cleveland Clin Fdn, Dept Colon & Rectal Surg, Cleveland, OH USA.
   [Sebastian, Shaji] Hull Univ Teaching Hosp, Dept Gastroenterol, IBD Unit, Kingston Upon Hull, England.
   [Wong, Serre-Yu] Icahn Sch Med Mt Sinai, Dept Med, Henry D Janowitz Div Gastroenterol, New York, NY USA.
   [Tozer, Phil] St Marks Hosp, Dept Colon & Rectal Surg, London, England.
   [Cohen, Benjamin L.] Cleveland Clin Fdn, Dept Gastroenterol & Hepatol, Cleveland, OH USA.
C3 Cleveland Clinic Foundation; Icahn School of Medicine at Mount Sinai;
   Imperial College London; Cleveland Clinic Foundation
RP Holubar, SD (通讯作者)，Cleveland Clin, Dept Colon & Rectal Surg, 9500 Euclid Ave,A30, Cleveland, OH 44122 USA.
EM holubas@ccf.org
RI Wong, Serre-Yu/JFK-7215-2023; Erözkan, Kamil/GVU-7136-2022; Holubar,
   FACS, FASCRS, Stefan D/I-3798-2019; Holubar, Stefan/I-3798-2019
OI Wong, Serre-Yu/0000-0002-2070-4123; Erözkan, Kamil/0000-0003-2193-9984;
   Holubar, FACS, FASCRS, Stefan D/0000-0002-2549-9042; 
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NR 50
TC 8
Z9 9
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1078-0998
EI 1536-4844
J9 INFLAMM BOWEL DIS
JI Inflamm. Bowel Dis.
PD APR
PY 2025
VL 31
IS 4
BP 1150
EP 1157
DI 10.1093/ibd/izae198
EA OCT 2024
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 1XY8R
UT WOS:001333856800001
PM 39418126
DA 2026-07-24
ER
PT J
AU Sanchez, MC
   Cañizares, S
   Hollis, R
   Yamada, J
   Cooper, M
AF Sanchez, Maria Cardenas
   Canizares, Stalin
   Hollis, Russell
   Yamada, Jaclyn
   Cooper, Michael
TI A Case Series Describing Combined Negative Pressure Wound Therapy and
   Split-Thickness Skin Graft as a Method of Sterilizing and Closing
   Midline Laparotomy Wounds Near Ostomies
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Negative Pressure Wound Therapy; Split-Thickness Skin Graft; Laparotomy
   Wounds; Ostomies
ID VACUUM-ASSISTED CLOSURE; METAANALYSIS; MANAGEMENT; MECHANISMS; DRESSINGS
AB Background: Negative pressure wound therapy (NPWT) promotes wound sterilization, improves tissue granulation, and ensures appropriate wound healing. Its potential in contaminated abdominal procedures is still under study, but the results are promising. Purpose: This research provides insight into the use of NPWT for the effective preparation of laparotomy wounds in close proximity to ostomies. It also demonstrates the application of NPWT systems for successful skin graft take under these conditions. Methods: The authors describe 3 cases in the burn unit of an academic hospital in the northeastern United States treated successfully with a combination of NPWT and skin grafting to manage open abdominal laparotomy wounds in close proximity to ostomies. Results: NPWT improved skin graft survival by promoting the creation of a clean base, which is important for ensuring appropriate skin graft take, and strengthening the bond between the graft and the recipient wound bed. Conclusion: Despite these successful results, evidence in this area is still mixed and would benefit from further studies in the field.
C1 [Sanchez, Maria Cardenas; Hollis, Russell; Yamada, Jaclyn; Cooper, Michael] Northwell Hlth, 430 Lakeville Rd, New Hyde Pk, NY 11042 USA.
   [Sanchez, Maria Cardenas; Hollis, Russell; Yamada, Jaclyn; Cooper, Michael] Dept Surg Zucker Sch Med, Dept Surg, Uniondale, NY USA.
   [Canizares, Stalin] Univ San Francisco Quito, Quito, Ecuador.
C3 Northwell Health; Universidad San Francisco de Quito
RP Sanchez, MC (通讯作者)，Northwell Hlth, 430 Lakeville Rd, New Hyde Pk, NY 11042 USA.
EM mcardenas4@northwell.edu
RI Cañizares Quisiguiña, Stalin/HSF-1691-2023
OI Hollis, Russell/0000-0003-0143-3337
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   Petkar K, 2012, EUR J PLAST SURG, V35, P579, DOI 10.1007/s00238-012-0698-y
   Pliakos I, 2012, AM SURGEON, V78, P957
   Runkel N, 2011, INJURY, V42, pS1, DOI 10.1016/S0020-1383(11)00041-6
   Shehata MSA, 2022, WOUNDS, V34, pE126, DOI 10.25270/wnds/21061
   Stanley BJ, 2013, VET SURG, V42, P511, DOI 10.1111/j.1532-950X.2013.12005.x
   Stevens P, 2009, INT WOUND J, V6, P259, DOI 10.1111/j.1742-481X.2009.00614.x
   Subramonia S, 2009, WORLD J SURG, V33, P931, DOI 10.1007/s00268-009-9947-z
   Vargo D, 2009, AM SURGEON, V75, pS1
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
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   Yeung E, 2021, J SURG RES, V259, P313, DOI 10.1016/j.jss.2020.09.031
   Zens Y, 2020, SYST REV-LONDON, V9, DOI 10.1186/s13643-020-01476-6
   Zhang CW, 2014, AESTHET PLAST SURG, V38, P727, DOI 10.1007/s00266-014-0341-3
NR 33
TC 0
Z9 0
U1 0
U2 2
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD SEP
PY 2024
VL 70
IS 3
AR wmp23036
DI 10.25270/wmp.23036
PG 12
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA J1O0T
UT WOS:001334822500001
PM 39361346
DA 2026-07-24
ER
PT J
AU Sun, QY
   Li, SY
   Xu, HY
   Guan, XX
   Ye, FF
AF Sun, Qiaoyun
   Li, Suyan
   Xu, Hongyan
   Guan, Xiaoxaio
   Ye, Feifei
TI Experience With Wound Care in a Case With ECMO Cannulation Using a
   Self-Made Vacuum Sealing Drainage Device With Constant- Temperature
   Flushing
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE ECMO; Vacuum Sealing Drainage; Incision Care
AB Background:This : This study reports experience of wound care at the site of cannulation in the case of a patient with dilated cardiomyopathy (DCM) weaned from extracorporeal membrane oxygenation (ECMO). Purpose: To describe the use of a self-made vacuum-sealing drainage device with constant-temperature flushing to manage wound exudates in the cannulation site, aiming to create an environment conducive to wound healing. Materials and Methods: Exudates from the wound were processed using the vacuum-sealing drainage technique combined with constant-temperature flushing. Anti-infective agents were systemically administered to control infection and promote wound healing. Additionally, the patient's nutritional status, pain management, psychological well-being, and rehabilitation were assessed and managed as part of the comprehensive care approach. Results: The wound exhibited gradual healing under this multifaceted care strategy. After 48 days of treatment, the patient demonstrated stable disease conditions and achieved wound closure. The patient was subsequently transferred to a general ward for further care. Conclusion: The use of a self-made vacuum-sealing drainage device with constant-temperature flushing, along with comprehensive patient management, proved effective in wound care for a critically ill patient with ECMO cannulation. This approach fosters an optimal environment for wound healing and contributes to patient recovery and stability.
C1 [Sun, Qiaoyun; Li, Suyan] Zhejiang Xiaoshan Hosp, Dept Emergency Intens Care Unit, Hangzhou, Zhejiang, Peoples R China.
   [Xu, Hongyan] Zhejiang Xiaoshan Hosp, Nursing Dept, Hangzhou, Zhejiang, Peoples R China.
   [Guan, Xiaoxaio; Ye, Feifei] Zhejiang Hosp, Dept Crit Care Med, Lingyin Rd 12, Hangzhou, Zhejiang, Peoples R China.
RP Ye, FF (通讯作者)，Zhejiang Hosp, Dept Crit Care Med, Lingyin Rd 12, Hangzhou, Zhejiang, Peoples R China.
EM 821900464@qq.com
CR Bhardwaj H, 2026, INT J LOW EXTR WOUND, V25, P284, DOI 10.1177/15347346241228788
   Blaser AR, 2017, INTENS CARE MED, V43, P380, DOI 10.1007/s00134-016-4665-0
   Chen M, 2019, INDIAN J DERMATOL VE, V85, P605, DOI 10.4103/ijdvl.IJDVL_873_17
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NR 13
TC 0
Z9 1
U1 0
U2 3
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD SEP
PY 2024
VL 70
IS 3
AR 23070
DI 10.25270/wmp.23070
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA J1O0T
UT WOS:001334822500004
PM 39361345
DA 2026-07-24
ER
PT J
AU Ye, RT
   Ni, L
   Cheng, QY
AF Ye, Rentong
   Ni, Liang
   Cheng, Qianyu
TI Evaluation of the Efficacy of Vacuum Sealing Drainage in Combination
   With Silver-Containing Dressings for the Improvement of Chronic
   Refractory Wounds
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Vacuum Sealing Drainage; Silver-Containing Dressing; Chronic Refractory
   Wound; Treatment Efficacy; Inflammatory State
ID PLATELET-RICH FIBRIN; THERAPY
AB Purpose: The aim of this study was to explore the clinical efficacy of vacuum sealing drainage in combination with silver-containing dressings for the treatment of chronic refractory wounds. Methods: In this retrospective study, 80 patients with chronic refractory wounds who were treated in the hospital were retrospectively selected as the study objects. Based on the treatment modalities, the patients were divided into the study group (SG; n=40, receiving vacuum sealing drainage combined with silver-containing dressings) and the control group (CG; n = 40, receiving vacuum sealing drainage alone). Results: The total effective rate of the SG was 92.5%, significantly higher than the 75% in the CG. After treatment, the SG exhibited lower positive rates in bacterial culture, as well as decreased levels of C-reactive protein and erythrocyte sedimentation rate compared to the CG. Starting from the sixth day of treatment, the SG reported statistically significant lower pain intensity scores than the CG. Additionally, the SG exhibited significantly lower dimension scores in terms of scar thickness, color, tenderness, and vascular distribution compared to the CG. Conclusion: The combined application of vacuum sealing drainage and silver-containing dressings demonstrated a positive treatment efficacy for patients with chronic refractory wounds.
C1 [Ye, Rentong; Ni, Liang; Cheng, Qianyu] Lanxi Peoples Hosp, Dept Plast Burn & Wound Repair, 1359 Xishan Rd, Jinhua 321100, Zhejiang, Peoples R China.
RP Cheng, QY (通讯作者)，Lanxi Peoples Hosp, Dept Plast Burn & Wound Repair, 1359 Xishan Rd, Jinhua 321100, Zhejiang, Peoples R China.
EM Chengqianyu2023@163.com
CR Anzali BC, 2023, INT J SURG CASE REP, V105, DOI 10.1016/j.ijscr.2023.107970
   Dong XM, 2022, J CRANIOFAC SURG, V33, P2028, DOI 10.1097/SCS.0000000000008473
   Duplessis CA, 2020, ANTIBIOTICS-BASEL, V9, DOI 10.3390/antibiotics9070377
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   Liu P, 2021, WORLD J CLIN CASES, V9, P4797, DOI 10.12998/wjcc.v9.i18.4797
   Liu XM, 2022, ADV SCI, V9, DOI 10.1002/advs.202105650
   Liu Y, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.918223
   Lu Q, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-045866
   Lv Y, 2024, INT J LOW EXTR WOUND, V23, P275, DOI 10.1177/15347346211050710
   Ogawa R, 2022, PLAST RECONSTR SURG, V149, p79E, DOI 10.1097/PRS.0000000000008667
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   Wu YZ, 2023, INT WOUND J, V20, P2113, DOI 10.1111/iwj.14086
   Xing D, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021148
   Xue X, 2022, FRONT BIOENG BIOTECH, V10, DOI 10.3389/fbioe.2022.979834
   Yan CQ, 2022, DRUG DELIV, V29, P214, DOI 10.1080/10717544.2021.2023699
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NR 26
TC 2
Z9 2
U1 1
U2 8
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD SEP
PY 2024
VL 70
IS 3
AR 23067
DI 10.25270/wmp.23067
PG 11
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA J1O0T
UT WOS:001334822500005
PM 39361340
DA 2026-07-24
ER
PT J
AU Wu, ZY
   Huang, HY
   Shi, YC
   Li, J
   Liao, SM
   Xu, SH
   Xian, JJ
   Cai, XF
   Zhang, PH
   Wu, ZY
AF Wu, Zeyong
   Huang, Haiyan
   Shi, Yucang
   Li, Jin
   Liao, Simu
   Xu, Shuhao
   Xian, Jiajie
   Cai, Xiaofen
   Zhang, Peihua
   Wu, Zhiyuan
TI Clinical study of matrix vascular component gel combined with vacuum
   sealing drainage technique in chronic wounds
SO BIOMEDICAL MATERIALS
LA English
DT Article
DE adipose extracellular matrix/stromal vascular fraction gel;
   adipose-derived stem cells; VSD; chronic wounds
ID EXTRACELLULAR-MATRIX; FRACTION GEL; STEM-CELL
AB This study investigates the efficacy of the combination of extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) and vacuum sealing drainage (VSD) on chronic wounds. From February 2021 to February 2022, 20 patients with chronic wounds were recruited and were divided into experimental and control groups, with 10 patients in each group. Following debridement, we applied various treatments to all cases for 2 weeks. Subsequently, we observed the changes in the wound area and calculated the rate of wound healing. Simultaneously, the wound margin tissues were collected for histological analysis, and the inflammatory cell infiltration within the wound was assessed using HE staining. Masson staining was used to observe the collagen deposition on the wound surface, and CD31 immunohistochemistry was used to count the number of microvessels to evaluate the angiogenesis (Clinical trial registration number: ChiCTR-INR-17 013 540). The therapeutic outcomes for all cases included in this study were favorable after a two-week treatment period, and the wound area was smaller than before. The experimental group exhibited a significantly higher rate of wound healing compared to the control group. As revealed by HE staining in the experimental group, there was a marked reduction in the infiltration of inflammatory cells in the dermis. Masson staining demonstrated that the deposition of collagen fibers in the experimental group was more than the control group. CD31 immunohistochemistry showed an increased number of new blood vessels in the experimental group compared to the control group. Additionally, ECM/SVF-gel extract significantly enhanced the fibroblast proliferation and migration in vitro. The application of ECM/SVF gel combined with VSD in chronic wounds can accelerate wound healing by reducing inflammatory reaction, increasing collagen fiber deposition, and promoting angiogenesis. Therefore, the combination of ECM/SVF gel and VSD can be used as a simple, safe, and effective therapeutic method for chronic wounds.
C1 [Wu, Zeyong; Huang, Haiyan; Shi, Yucang; Li, Jin; Liao, Simu; Xu, Shuhao; Xian, Jiajie; Cai, Xiaofen; Zhang, Peihua; Wu, Zhiyuan] Guangdong Med Univ, Affiliated Hosp, Plast Surg, Zhanjiang, Guangdong, Peoples R China.
C3 Guangdong Medical University
RP Zhang, PH; Wu, ZY (通讯作者)，Guangdong Med Univ, Affiliated Hosp, Plast Surg, Zhanjiang, Guangdong, Peoples R China.
EM zhangph@gdmu.edu.cn; 18820620888@163.com
RI Huang, Huanghaiyan/IQW-8615-2023; shi, yucang/LFV-3234-2024; wu,
   zeyong/GZM-7313-2022
FU Clinical Research Project of Affiliated Hospital of Guangdong Medical
   University [LCYJ2017A001]; National Stem Cell Clinical Research Record
   Project [MR-44-21-015762]; Zhanjiang Science and Technology Plan Project
   [2022A01189]; The 2021 Zhanjiang City Science and Technology Development
   Special Fund Competitive Allocation Project [2021A05081]; The 2014
   Zhanjiang City Financial Fund Science and Technology Special Competitive
   Allocation Project [2014C01022]
FX The study was supported by the Clinical Research Project of Affiliated
   Hospital of Guangdong Medical University [No. LCYJ2017A001], the
   National Stem Cell Clinical Research Record Project [No.
   MR-44-21-015762], Zhanjiang Science and Technology Plan Project [No.
   2022A01189], 2021 Zhanjiang City Science and Technology Development
   Special Fund Competitive Allocation Project [No. 2021A05081], and 2014
   Zhanjiang City Financial Fund Science and Technology Special Competitive
   Allocation Project [No. 2014C01022].
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NR 41
TC 7
Z9 7
U1 0
U2 6
PU IOP Publishing Ltd
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1748-6041
EI 1748-605X
J9 BIOMED MATER
JI Biomed. Mater.
PD NOV 1
PY 2024
VL 19
IS 6
AR 065029
DI 10.1088/1748-605X/ad80ed
PG 13
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA J1P6A
UT WOS:001334862600001
PM 39332443
DA 2026-07-24
ER
PT J
AU Kadota, H
   Oryoji, C
   Fukushima, S
   Shimamoto, R
   Kamizono, K
   Yoshida, S
AF Kadota, Hideki
   Oryoji, Chikafumi
   Fukushima, Seita
   Shimamoto, Ryo
   Kamizono, Kenichi
   Yoshida, Sei
TI Combined local flap placement and negative-pressure wound therapy for
   the management of critical peritracheostomal pharyngocutaneous fistula
SO AURIS NASUS LARYNX
LA English
DT Article
DE Total laryngectomy; Pharyngocutaneous fistula; Local flap;
   Negative-pressure wound therapy; Peritracheostomal fistula
ID VACUUM-ASSISTED CLOSURE; SALVAGE TOTAL LARYNGECTOMY; PECTORALIS
   MYOFASCIAL FLAP; MAJOR MUSCLE FLAP; HEAD; PREVENTION; COMPLICATIONS;
   RECONSTRUCTION; SURGERY
AB Objective: Peritracheostomal pharyngocutaneous fistula (PCF), a direct connection between the PCF and tracheal stoma due to a skin defect, is among the most problematic complications after total laryngectomy or pharyngolaryngectomy. Peritracheostomal PCFs can cause lethal complications, including severe pneumonia or carotid blowout, secondary to salivary leakage directly into the tracheal stoma, and their management is challenging without early invasive surgical closure. We aimed to evaluate the utility of our novel and minimally invasive combined local skin flap placement and negative-pressure wound therapy (NPWT) method for the management and conservative closure of peritracheostomal PCFs. Methods: We retrospectively enrolled patients who developed a peritracheostomal PCF from July 2015 to September 2021 at our institution and affiliated hospitals. Postoperative PCFs were all initially managed with appropriate wound bed preparation. Subsequently, a small local flap of healthy, lower neck skin was elevated and transferred anterior to the PCF to replace the peritracheostomal skin defect. The flap served to provide a sufficient surface for film dressing attachment and facilitated airtight sealing during NPWT. We initiated NPWT after confirming the local skin flap was firmly sutured to the tracheal mucosa. A flexible hydrocolloid dressing was applied to the peritracheostomal skin flap, and a film dressing was placed on the flexible hydrocolloid dressing and surrounding cervical skin. We inserted the NPWT foam shallowly into the fistula tract and applied negative pressure (73.5-125 mmHg). NPWT was continued until the PCF was closed or became so small that salivary leakage was minimal and could be managed by conventional compression dressings. Results: We enrolled six patients [male, n = 6; mean age, 66.5 years (range, 57-80 years)]. NPWT was applied for an average of 18.2 days (range, 2-28 days). During NPWT, air leakage occurred once (2 cases), only a few times (2 cases), or not at all (2 cases). In all patients, complete fistula closure was achieved in an average of 28.2 days (range, 15-55 days) after the start of NPWT, and no patient required further surgical intervention. There were no lethal complications (e.g., severe pneumonia) during treatment. Conclusion: Our method of combined local flap placement and NPWT enabled effective management of salivary aspiration and accelerated wound healing, which allowed conservative fistula closure in all patients. We believe combined local flap placement and NPWT should be considered a first-line treatment for intractable peritracheostomal PCF.
C1 [Kadota, Hideki; Oryoji, Chikafumi; Fukushima, Seita; Kamizono, Kenichi; Yoshida, Sei] Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan.
   [Shimamoto, Ryo] Natl Kyushu Canc Ctr, Dept Plast Surg, Fukuoka, Japan.
C3 Kyushu Cancer Center
RP Kadota, H (通讯作者)，Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan.
EM kadota.hideki.239@m.kyushu-u.ac.jp
RI Kadota, Hideki/AAU-7710-2020
OI Kadota, Hideki/0000-0001-7833-3524
FX We would like to thank Ami_2, our preferred Editage editor ( www.ed
   itage.com ) , for English language editing.
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NR 41
TC 3
Z9 3
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0385-8146
EI 1879-1476
J9 AURIS NASUS LARYNX
JI Auris Nasus Larynx
PD DEC
PY 2024
VL 51
IS 6
BP 964
EP 970
DI 10.1016/j.anl.2024.09.008
EA OCT 2024
PG 7
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA J2V9L
UT WOS:001335706100001
PM 39388749
DA 2026-07-24
ER
PT J
AU Simsek, HU
   Tatar, OC
   Simsek, T
AF Simsek, Hayal Uzelli
   Tatar, Ozan Can
   Simsek, Turgay
TI Vulvar necrotizing wounds: Unveiling mortality-associated parameters and
   assessing the efficacy of VAC therapy
SO EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
LA English
DT Article
DE Infection; Necrotizing Fasciitis; Wound; Vacuum-Assisted Closure
ID FOURNIERS GANGRENE; ASSISTED CLOSURE; FASCIITIS; COHORT
AB Introduction: Vulvar Necrotizing Fasciitis (VNF) is a critical, severe soft tissue infection characterized by aggressive progression and significant morbidity and mortality. Rapid diagnosis and immediate, comprehensive treatment, including antibiotic therapy, meticulous surgical debridement, and multidisciplinary care, are crucial for improving outcomes. This study aimed to investigate mortality-related factors in VNF and evaluate treatment modalities, focusing on Vacuum-Assisted Closure (VAC) therapy versus traditional debridement. Methods: This retrospective study analyzed data from 22 VNF patients. Criteria included adults diagnosed with vulvar necrotizing infections, excluding those transferred or not completing treatment at the center. The study examined mortality-related factors and the efficacy of VAC therapy compared to debridement, considering treatment costs and outcomes. Results: Analysis divided patients into survivors (13) and non-survivors (9). Higher heart rate, elevated WBC and CRP levels, and higher Clavien-Dindo scores were associated with increased mortality. VAC therapy, compared to traditional debridement, resulted in significantly lower CRP levels and reduced treatment costs. However, other parameters such as the length of hospital stay and debridement frequency showed no significant differences. Conclusion: The study highlights that older age, systemic inflammation, and severe postoperative complications are key factors associated with higher mortality in VNF. VAC therapy emerges as a promising modality, effectively reducing systemic inflammation and healthcare costs. Nonetheless, the retrospective nature and the small sample size of the study limit the generalizability of the findings. Future research, particularly larger, multicentric studies, is essential to further explore and validate the effectiveness of VAC therapy in VNF management.
C1 [Simsek, Hayal Uzelli] Kocaeli Univ, Dept Gynecol & Obstet, Izmit, Turkiye.
   [Tatar, Ozan Can; Simsek, Turgay] Kocaeli Univ, Dept Gen Surg, Izmit, Turkiye.
C3 Kocaeli University; Kocaeli University
RP Tatar, OC (通讯作者)，Kocaeli Univ, Dept Gen Surg, Izmit, Turkiye.
EM ozancantatar@gmail.com
RI şimşek, hayal uzelli/AAB-3626-2022; Tatar, Ozan/AAR-8524-2020; ŞİMŞEK,
   Turgay/AAS-1708-2020
OI şimşek, hayal uzelli/0000-0002-1197-1326; 
CR Afzal M, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.46140
   Allaw F, 2024, CURR OPIN INFECT DIS, V37, P105, DOI 10.1097/QCO.0000000000000988
   Assenza M, 2011, CLIN TER, V162, pE1
   Desai R, 2023, UROLOGIA J, V90, P201, DOI 10.1177/03915603231165067
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   Harbrecht BG, 2016, SURG INFECT, V17, P503, DOI 10.1089/sur.2016.049
   Hua C, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011680.pub2
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NR 18
TC 0
Z9 0
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-2115
EI 1872-7654
J9 EUR J OBSTET GYN R B
JI Eur. J. Obstet. Gynecol. Reprod. Biol.
PD DEC
PY 2024
VL 303
BP 48
EP 52
DI 10.1016/j.ejogrb.2024.10.022
EA OCT 2024
PG 5
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA J4Z4A
UT WOS:001337159700001
PM 39413549
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Kisielewski, M
   Richter, K
   Pisarska-Adamczyk, M
   Wysocki, M
   Klos, N
   Stefura, T
   Wojewoda, T
   Wysocki, WM
AF Kisielewski, Michal
   Richter, Karolina
   Pisarska-Adamczyk, Magdalena
   Wysocki, Michal
   Klos, Nikola
   Stefura, Tomasz
   Wojewoda, Tomasz
   Wysocki, Wojciech M.
TI Incisional Negative Pressure Wound Therapy Versus Primary Wound Suturing
   after Intestinal Ostomy Closure: A Systematic Review and Meta-Analysis
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; stoma closure; NPWT; primary wound
   suturing; meta-analysis
ID SURGICAL-SITE INFECTIONS; ENHANCED RECOVERY; HOSPITAL STAY; REVERSAL;
   REDUCE; SURGERY; RISK
AB Objective: Wound infection after intestinal ostomy closure is a very common postoperative complication. An alternative to primary wound suturing by single sutures or purse string sutures (PSS) is applying incisional negative pressure wound therapy (iNPWT). The aim of the following systematic review and meta-analysis was to assess and compare clinical outcomes in patients after PSS and iNPWT use. Approach: The aim of the study was to find relevant clinical data comparing outcomes of iNPWT and primary wound closure after intestinal ostomy closure. The search was conducted using the MEDLINE/PubMed, ScienceDirect, EMBASE, Scopus, Cochrane Controlled Register of Trials, SciELO, and Web of Science databases and took place up to November 12, 2022. The authors did not use date or language filters. Statistical analysis was performed using Review Manager 5.4 (The Cochrane Collaboration, 2020, London, UK). The authors conducted a meta-analysis of the following four parameters: wound healing time (WHT), surgical site infections (SSIs), complications, and length of hospital stay (LOS). Odds ratios (OR) and inverse variance (IV) were generated with 95% confidence intervals (CI). The meta-analysis was registered in the International Prospective Register of Systematic Reviews database under registration number CRD42023391640. Results: The analysis revealed that the iNPWT group and the control group did not differ significantly with regard to the WHT parameter (Z = 2,73; p = 0.006; chi(2) = 0.37, df = 1, p = 0.54, I-2 = 0%). Meta-analysis of SSI incidence revealed a significant difference favoring the iNPWT group over the observational group (OR = 0.42; 95% CI = 0.25-0.72; p = 0.002; I-2 = 14%). Patients included in the iNPWT group had a significantly lower pooled incidence of overall complications than the observational group (OR = 0.52; 95% CI = 0.35-0.77; p = 0.001, I-2 = 71%). Subgroup analysis limited to randomized studies also presented significant differences favoring the iNPWT group over the observational group (OR = 0.27; 95% CI = 0.14-0.52; p < 0.001, I-2 = 67%). Our analysis showed that LOS did not differ significantly between the groups treated with and without iNPWT (IV = 0.19; 95% CI = -0.66 -1,04; p = 0.76, I-2 = 0%). In addition, subgroup analysis of randomized studies also did not present a significant difference (IV = 0.25; 95% CI = -0.80 -1,30; p = 0.33, I-2 = 10%). Innovation: This study shows that the use of iNPWT can reduce the risk of SSIs with other complications, such as wound hematomas, wound seromas, wound dehiscence, fistulas, and ileus, in patients undergoing intestinal ostomy closure without extended hospital stay. Conclusions: Use of iNPWT can be considered in postoperative care after elective ostomy closure to decrease the rate of the most common complications after ostomy closure.
C1 [Kisielewski, Michal; Richter, Karolina; Klos, Nikola; Wojewoda, Tomasz; Wysocki, Wojciech M.] Andrzej Frycz Modrzewski Cracow Univ, Fac Med & Hlth Sci, Chair Surg, Krakow, Poland.
   [Kisielewski, Michal; Pisarska-Adamczyk, Magdalena] 5th Mil Clin Hosp, Dept Gen & Oncol Surg, Krakow, Poland.
   [Richter, Karolina] 5th Mil Clin Hosp, Krakow, Poland.
   [Pisarska-Adamczyk, Magdalena; Stefura, Tomasz] Jagiellonian Univ Med Coll, Dept Med Educ, Krakow, Poland.
   [Wysocki, Michal] Ludw Rydygier Mem Hosp, Dept Gen Surg & Surg Oncol, Krakow, Poland.
   [Klos, Nikola] Dist Hosp, Chrzanow, Poland.
   [Stefura, Tomasz] Ludw Rydygier Mem Hosp, Malopolska Ctr Burns & Plast Surg, Krakow, Poland.
   [Richter, Karolina; Wojewoda, Tomasz; Wysocki, Wojciech M.] 5th Mil Clin Hosp, Dept Oncol Surg, Wroclawska 1-3, PL-30901 Krakow, Poland.
   [Wysocki, Wojciech M.] Maria Sklodowska Curie Natl Res Inst Oncol, Warsaw, Poland.
C3 Andrzej Frycz Modrzewski Krakow University; Jagiellonian University;
   Collegium Medicum Jagiellonian University
RP Richter, K (通讯作者)，5th Mil Clin Hosp, Dept Oncol Surg, Wroclawska 1-3, PL-30901 Krakow, Poland.
EM karolinaa.richter@gmail.com
RI ; Stefura, Tomasz/CAA-5539-2022; Kisielewski, Michał/AAY-8327-2020;
   Pisarska-Adamczyk, Magdalena/ABD-7785-2020
OI Richter, Karolina/0000-0001-6151-0571; 
FU Andrzej Frycz Modrzewski Cracow University [WDPR/2024/03/00002,
   WSUB/2024/03/00002]
FX This study was supported by Andrzej Frycz Modrzewski Cracow University -
   grants WDPR/2024/03/00002 and WSUB/2024/03/00002.
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NR 35
TC 3
Z9 3
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD APR 1
PY 2025
VL 14
IS 4
BP 199
EP 209
DI 10.1089/wound.2024.0100
EA OCT 2024
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0UF9S
UT WOS:001337803500001
PM 39135388
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ensor, N
   Martin, S
   Chang, ANT
   Sharpin, C
   Tandon, S
   Madden, A
   Syme, D
   Pacilli, M
   Nataraja, R
AF Ensor, Nicholas
   Martin, Sarah
   Chang, Annette
   Sharpin, Claire
   Tandon, Sarthak
   Madden, Andrew
   Syme, Duncan
   Pacilli, Maurizio
   Nataraja, Ram
TI Negative Pressure Dressing Versus Conventional Passive Dressing in
   Pilonidal Surgery: A Randomized Controlled Trial
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Dehiscence; Karydakis; Negative pressure wound therapy; Pilonidal sinus;
   Primary closure
ID SINUS; COMPLICATIONS; FLAP; RISK
AB Introduction: Surgically treated pilonidal sinus disease (PSD) has high rates of postoperative wound complications, with surgical wound dehiscence (SWD) rates up to 44%. Negative pressure wound therapy (NPWT) is proposed to reduce rates of SWD for other high risk surgical wounds. Our aim was to investigate whether NPWT would reduce rates of SWD compared to conventional passive (CP) dressings for PSD excisions with off-midline primary closure. Our secondary outcomes included patient quality of life and time taken return to normal activities. Method: We performed a prospective, crossover pediatric/adult randomized controlled trial for patients (12-40 y) with PSD, requiring excision and off-midline primary closure. Participants were randomized to receive a CP (Primapore or Opsite) or NPWT (SNAP) dressing. Follow-up occurred on D3, D7, D10, D14 and then weekly until wound healing. Patients were sent a 2-month postoperative online survey to assess quality of life outcomes. Results: Fifty patients were recruited, 25 to NPWT & 25 to CP. Mean age and body mass index were 22.6 f 6.7 y and 26.1 f 4.5 kg/m(2), respectively. 36/50 (76%) were male. The overall dehiscence rate was 42% (21/50); 12/25 (48%) for NPWT & 9/25 (36%) for CP, P = 0.6. Five deep (>= 5 mm) SWDs occurred in each group, P > 0.9. SWD was associated with increased excision dimensions in the NPWT group only, P = 0.03. Median duration to wound healing was equivalent in nondehisced wounds, (CP 21.0 [14.0-29.5] versus NPWT 21.0 [16.0-24.0] days, P = 0.7). There were no differences in mean time to the following: return to school/work (NPWT 26.1 f 18.2 versus CP 29.3 f 14.7 d, P = 0.6), sit normally (NPWT 22.3 f 16.2 versus CP 20.1 f 9.4 d, P = 0.7), or return to physical activity (NPWT21.6 f 17.2 versus CP40.3 f 2.4 d, P = 0.2). Conclusions: NPWT did not improve outcomes after excision of PSD with off-midline primary closure. Despite the limited population size, our results do not support its use as a routine preventative measure. Crown Copyright (c) 2024 Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Ensor, Nicholas; Chang, Annette; Sharpin, Claire; Tandon, Sarthak; Pacilli, Maurizio; Nataraja, Ram] Monash Childrens Hosp, Dept Paediat Surg Urol & Surg Simulat, Melbourne, Australia.
   [Martin, Sarah] Monash Hlth, Dept Gen Surg, Melbourne, Australia.
   [Martin, Sarah; Pacilli, Maurizio; Nataraja, Ram] Monash Univ, Fac Med, Sch Clin Sci Nursing & Hlth Sci, Dept Surg, Melbourne, Australia.
   [Madden, Andrew; Syme, Duncan] Monash Hlth, Dept Hosp Home, Melbourne, Australia.
   [Pacilli, Maurizio; Nataraja, Ram] Monash Univ, Fac Med, Sch Clin Sci Nursing & Hlth Sci, Dept Paediat, Melbourne, Australia.
C3 Monash Health; Monash University; Monash Health; Monash University
RP Nataraja, R (通讯作者)，Monash Univ, Monash Childrens Hosp, Dept Paediat Surg, 246 Clayton Rd, Melbourne 3168, Australia.
EM ram.nataraja@monashhealth.org
RI Nataraja, Ramesh/AAI-2975-2020; Pacilli, Maurizio/O-3714-2017
OI Nataraja, Ramesh/0000-0003-4438-0263; Ensor,
   Nicholas/0000-0001-8528-0432; 
CR Arslan K, 2014, TECH COLOPROCTOL, V18, P29, DOI 10.1007/s10151-013-0982-2
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NR 20
TC 2
Z9 3
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD NOV
PY 2024
VL 303
BP 313
EP 321
DI 10.1016/j.jss.2024.09.016
EA OCT 2024
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J6M3G
UT WOS:001338183700001
PM 39393119
DA 2026-07-24
ER
PT J
AU Porfidia, R
   Grimaldi, S
   Ciolli, MG
   Picarella, P
   Grimaldi, S
AF Porfidia, Raffaele
   Grimaldi, Simona
   Ciolli, Maria Giovanna
   Picarella, Pietro
   Grimaldi, Sergio
TI The Pivotal Role of Negative Pressure Wound Therapy in the Management of
   Enteroatmospheric Fistula: A Year-Long "Obstacle Marathon
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE malnutrition; negative pressure wound therapy; open abdomen; enteral
   stent; enteroatmospheric fistula
AB Background. Enteroatmospheric fistula (EAF) is an abnormal communication between the gastrointestinal tract and the atmosphere. This phenomenon is still considered one of the most significant challenges faced by general surgeons after abdominal surgery. Primary goals of managing EAF include controlling and diverting intestinal contents outside the abdominal cavity, protecting surrounding tissues from retraction, and promoting wound healing. Achieving these goals is not easy. EAF has a 40% mortality rate. Several techniques have been proposed for managing this problem, including negative pressure wound therapy. The use of bladder catheters, nipples, endoscopic stents, vascular grafts, and fistula funnel, among other options, in the management of EAF has also been described. Case Report. The patient in the current report underwent Hartmann reversal surgery. On postoperative day (POD) 5, he had an anastomotic leak with ischemia of the descending colon and the transverse colon. Resection of the ischemic colon was performed, followed by creation of a terminal ileostomy on the last ileal loop on the right side. The first small orifice of EAF appeared on POD 23, the second on POD 28, and the third on POD 45. On POD 253, the patient underwent resection of the fistulated loop, extensive vitreolysis of the entire small intestine, and mechanical jejunojejunal laterolateral anastomosis to reestablish the canalization toward the previous terminal ileostomy on the right side. Complete closure of the skin was evident on POD 358. Conclusion. There is no ideal treatment approach that is valid for all cases of EAF. Spontaneous closure of an EAF is unlikely but feasible in the setting of a single, deep lesion with limited output and when intestinal continuity is preserved.
C1 [Porfidia, Raffaele; Ciolli, Maria Giovanna; Picarella, Pietro; Grimaldi, Sergio] Casa Cura Villa Fiori, Naples, Italy.
   [Grimaldi, Simona] Univ Milan La Statale, Milan, Italy.
RP Porfidia, R (通讯作者)，Casa Cura Villa Fiori, Gen & Oncol Surg, Corso Italia 157, I-80011 Naples, Italy.
EM dottoreporfidia@gmail.com
CR Becker HP, 2007, SCAND J SURG, V96, P263, DOI 10.1177/145749690709600402
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   Porfidia Raffaele, 2020, Wounds, V32, pE114
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   Wainstein DE, 2023, SURGERY, V173, P1079, DOI 10.1016/j.surg.2022.12.001
NR 12
TC 0
Z9 0
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2024
VL 36
IS 9
BP 316
EP 322
DI 10.25270/wnds/24035
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA J7T5B
UT WOS:001339049400005
PM 39378350
DA 2026-07-24
ER
PT J
AU Rocks, MC
   Wu, M
   Comunale, V
   Agrawal, N
   Nicholas, RS
   Azad, A
   Hacquebord, JH
AF Rocks, Madeline C.
   Wu, Meagan
   Comunale, Victoria
   Agrawal, Nikhil
   Nicholas, Rebecca S.
   Azad, Ali
   Hacquebord, Jacques H.
TI Investigating the Association between Preflap Negative-Pressure Wound
   Therapy and Surgical Outcomes in Extremity Free Flap Reconstruction: A
   Systematic Review
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Review
DE soft tissue reconstruction; extremity trauma; negative-pressure wound
   therapy; systematic review
ID VACUUM-ASSISTED CLOSURE; FREE-TISSUE TRANSFER; LOWER-LIMB INJURY;
   MICROSURGICAL RECONSTRUCTION; FRACTURES; COVERAGE; SUBACUTE; PATIENT;
   TRAUMA
AB Background While prior studies have recommended immediate flap coverage within 72 hours of injury for soft tissue reconstruction for traumatic extremity injuries, recent evidence in the setting of advanced wound care techniques de-emphasizes the need for immediate coverage. Negative-pressure wound therapy (NPWT) has been an essential tool for extending the time to definitive soft tissue coverage. This study sought to elucidate the impact of preoperative NPWT use on the success of microsurgical reconstruction. Methods A literature search was conducted using the following databases from their inception up to February 2023: PubMed, OVID databases (Embase and Cochrane Library), Web of Science, and Scopus. Of 801 identified articles, 648 were assessed and 24 were included. Cases were divided based on whether NPWT was used preoperatively or not. Timing to definitive coverage, injury details, and basic demographics were recorded. Rates of flap failure, infection, bone nonunion, reoperation, and complications were compared between groups. Results A total of 1,027 patients and 1,047 flaps were included, of which 894 (85.39%) received preflap NPWT. The average time to definitive coverage for the NPWT and non-NPWT groups was 16 and 18 days, respectively. The NPWT group experienced lower postoperative complication rates than the non-NPWT group in all reported complications except for deep infections. Compared with the non-NPWT group, the NPWT group experienced lower rates of any flap failure (3.69 vs. 9.80%) and partial flap failure (2.24 vs. 6.54%). Conclusion Preoperative NPWT was associated with reduced postoperative complications, most importantly flap failure rates. This merits further investigation into the decision-making process for traumatic extremity reconstruction. Future prospective studies adopting standardized protocols with longer follow-up are required to better understand the potentially beneficial role of preoperative NPWT use in soft tissue reconstruction.
C1 [Rocks, Madeline C.] George Washington Sch Med & Hlth Sci, Washington, DC USA.
   [Wu, Meagan] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA USA.
   [Comunale, Victoria; Nicholas, Rebecca S.; Azad, Ali; Hacquebord, Jacques H.] NYU Langone Hlth, Dept Orthoped Surg, Div Hand Surg, New York, NY USA.
   [Agrawal, Nikhil; Hacquebord, Jacques H.] NYU Langone Hlth, Hansjorg Wyss Dept Plast Surg, New York, NY USA.
C3 George Washington University; Thomas Jefferson University; NYU Langone
   Medical Center; NYU Langone Medical Center
RP Rocks, MC (通讯作者)，George Washington Univ, Sch Med & Hlth Sci, 2300 1St NW, Washington, DC 20052 USA.
EM mrocks@gwu.edu
RI Nicholas, Rebecca/IAM-2265-2023; Agrawal, Nikhil/K-5252-2019
OI Rocks, Madeline/0000-0002-5766-2959; Nicholas,
   Rebecca/0000-0002-9114-7029
CR Aromataris E., 2020, JBI Evid Synth, DOI [10.46658/jbimes-20-08, 10.46658/JBIMES-24-06, DOI 10.46658/JBIMES-20-08, 10.46658/JBIMES-20-08]
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   Rinker B, 2008, PLAST RECONSTR SURG, V121, P1664, DOI 10.1097/PRS.0b013e31816a8d9d
   Starnes-Roubaud MJ, 2015, PRS-GLOB OPEN, V3, DOI 10.1097/GOX.0000000000000399
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   Zaver V., 2023, NEGATIVE PRESSURE WO
   Zeiderman MR, 2021, BURNS TRAUMA, V9, DOI 10.1093/burnst/tkab024
NR 32
TC 4
Z9 4
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD JUL
PY 2025
VL 41
IS 06
BP 515
EP 520
DI 10.1055/a-2434-5798
EA OCT 2024
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3LM5A
UT WOS:001345567000001
PM 39362644
DA 2026-07-24
ER
PT J
AU Kostiuk, V
   Fereydooni, S
   Setia, O
   Loh, SA
   Strosberg, D
   Tonnessen, BH
   Chaar, CIO
   Aboian, E
AF Kostiuk, Valentyna
   Fereydooni, Soraya
   Setia, Ocean
   Loh, Sarah A.
   Strosberg, David
   Tonnessen, Britt H.
   Chaar, Cassius Iyad Ochoa
   Aboian, Edouard
TI Comparative analysis of negative pressure wound therapy (PICO) and
   standard dressing application after arterial vascular reconstructions
SO VASCULAR
LA English
DT Article
DE Surgical wound infection; surgical wound; negative pressure wound
   therapy; PICO dressing; arterial reconstruction
ID GROIN; TRANSVERSE; INFECTION; INCISION
AB Introduction: Surgical site infections following arterial reconstructions with femoral exposures are common and potentially preventable. Negative pressure wound therapy has emerged as a potential solution to minimize groin wound complications. Our study evaluates efficacy of a negative pressure therapy (PICO dressing) in reducing groin wound complications after vascular reconstructions. Methods: A retrospective single center comparative analysis of vascular reconstructions involving common femoral artery dissection was performed between July 2021 and June 2023. Patients were divided into two groups: patients treated with PICO device and patients who received standard dressing (non-PICO). Patient demographics, comorbidities, vascular evaluation, and procedure indications were compared. Previous interventions, incision orientation and procedure types were noted. The wound complication categories were graded according to the Szilagyi classification: grade 1 (superficial infection/minor dehiscence), grade 2 (deep infection/major dehiscence), and grade 3 (artery or prosthetic involvement). Statistical significance level was determined at p < .05 for all analyses. Results: A total of 217 groin dissections in 184 patients were analyzed with 132 and 85 groin dissections in the PICO and non-PICO groups, respectively. The baseline characteristics were similar between the groups in terms of age, sex, BMI, and procedure indications. Prior endovascular procedures and re-operative groin surgeries were more prevalent in the PICO group. The use of antibiotics post-operatively for groin wound complication was greater in the non-PICO group. The incidence of wound complications was higher in the non-PICO group (29.4% vs 10.6%, p < .001). Multivariate logistic regression analysis determined that PICO dressing as well as hybrid and endovascular index procedures were associated with lower risks of groin complications. Conclusion: PICO dressing decreased the incidence of groin wound complications in patients undergoing open vascular reconstructions. This study highlights the value of adjunctive negative pressure therapy in reduction of wound complications after arterial reconstructions in the inguinal region.
C1 [Kostiuk, Valentyna; Fereydooni, Soraya] Yale Univ, Sch Med, New Haven, CT 06520 USA.
   [Setia, Ocean; Loh, Sarah A.; Strosberg, David; Tonnessen, Britt H.; Chaar, Cassius Iyad Ochoa; Aboian, Edouard] Yale Univ, Sch Med, Dept Surg, Div Vasc Surg & Endovasc Therapy, 333 Cedar St,Boardman Bldg, New Haven, CT 06520 USA.
C3 Yale University; Yale University
RP Aboian, E (通讯作者)，Yale Univ, Sch Med, Dept Surg, Div Vasc Surg & Endovasc Therapy, 333 Cedar St,Boardman Bldg, New Haven, CT 06520 USA.
EM edouard.aboian@yale.edu
RI Tonnessen, Britt/KIA-8309-2024
CR Audu CO, 2019, J VASC SURG, V69, P532, DOI 10.1016/j.jvs.2018.05.221
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   Kuyumdzhiev S, 2022, VASCULAR, V30, P1168, DOI 10.1177/17085381211051483
   Parikh PP, 2018, ANN VASC SURG, V47, P143, DOI 10.1016/j.avsg.2017.08.019
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NR 14
TC 1
Z9 1
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD DEC
PY 2025
VL 33
IS 6
BP 1304
EP 1310
DI 10.1177/17085381241296606
EA OCT 2024
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 9ZM7O
UT WOS:001346012600001
PM 39460535
DA 2026-07-24
ER
PT J
AU Jeong, JW
   Lee, S
   Park, JH
AF Jeong, Ji Won
   Lee, Seungkeun
   Park, Jun Ho
TI Closed-incision negative pressure wound therapy (NPWT) in elderly
   patients following sacral pressure sore reconstruction
SO BMC GERIATRICS
LA English
DT Article
DE Pressure sore; Pressure ulcer; Sacral sore; Negative pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; ULCERS; FLAP; PROLIFERATION; PREVALENCE;
   PREVENTION; CARE
AB Background Pressure sores significantly affect elderly patients, with the sacrum being especially vulnerable, often due to its proximity to the anus and potential for fecal contamination. Despite preventive measures such as frequent repositioning and specialized cushions, some sores still necessitate surgical intervention. Postoperative care focuses on monitoring, hygiene, and pressure alleviation. This study assessed the efficacy of Closed-Incision Negative Pressure Wound Therapy (CI-NPWT) for postoperative wound management in patients with sacral pressure sores treated with local flaps. Methods A retrospective analysis was performed on sacral sore patients who underwent reconstructive surgery from March 2019 through April 2023. Surgical procedures involved debridement and wound coverage using gluteal artery perforator-based fasciocutaneous flaps, followed by postoperative monitoring. Patients were grouped into conventional monitoring or NPWT management, with the latter utilizing the INFOV.A.C. The therapy unit was calibrated to 125 mmHg. Data on patient demographics, flap metrics, fluid drainage amounts, and six-month postoperative outcomes were collected, and then analyzed with SPSS Statistics. Results In this study of 52 patients with sacral pressure sores, the NPWT group (n = 25) showed significantly fewer flap complications and a lower drainage volume on the seventh postoperative day (mean 17.2 cc) compared to the conventional dressing group (mean 27.8 cc, P < 0.05). No postoperative complications were observed in the NPWT group, whereas the conventional group (n = 27) experienced one infection and three cases of dehiscence. Both groups achieved a 100% flap survival rate. Conclusion Closed-incision negative pressure wound therapy (CI-NPWT) shows promise in reducing wound dehiscence and infection rates in elderly patients undergoing sacral pressure sore reconstruction with local flaps. However, further research with larger, randomized studies is needed to confirm its effectiveness as an alternative to conventional postoperative care. Trial registration. The study was retrospectively registered by the Institutional Review Board of Seoul Metropolitan Government-Seoul National University Boramae Medical Center (No. 20-2023-25, Date: Mar. 24 2023).
C1 [Jeong, Ji Won; Park, Jun Ho] Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Plast & Reconstruct Surg, Coll Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea.
   [Lee, Seungkeun] Soonchunhyang Univ, Bucheon Hosp, Dept Neurol, Coll Med, Jomaru Ro 170, Bucheon 14584, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Soonchunhyang University
RP Park, JH (通讯作者)，Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Plast & Reconstruct Surg, Coll Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea.
EM jsean1@naver.com
FU Seoul Metropolitan Government-Seoul National University Boramae Medical
   Center Research Fund [0420230016]
FX This research was supported by a clinical research grant-in-aid from
   Seoul Metropolitan Government-Seoul National University Boramae Medical
   Center Research Fund (no. 0420230016)
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NR 41
TC 6
Z9 7
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD NOV 4
PY 2024
VL 24
IS 1
AR 906
DI 10.1186/s12877-024-05526-9
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA L0S6B
UT WOS:001347908900001
PM 39497041
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU von Rüden, C
   Wunder, J
   Schirdewahn, C
   Augat, P
   Hackl, S
AF von Rueden, Christian
   Wunder, Johannes
   Schirdewahn, Christoph
   Augat, Peter
   Hackl, Simon
TI Initial treatment of severe soft-tissue injuries in closed and open
   fractures to prevent fracture-related infection
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Fracture; Soft tissue damage; Lesion; Fracture-related infection (FRI);
   Antibiotics; Negative pressure wound therapy (NPWT); Fracture fixation;
   Gustilo and Anderson classification
ID PRESSURE WOUND THERAPY; LOWER-LIMB FRACTURES; OPEN TIBIA FRACTURES;
   LOWER-EXTREMITY; SURGICAL DEBRIDEMENT; MANAGEMENT; TRAUMA; TIME;
   AMPUTATION; SALVAGE
AB The management of soft tissue damage during fracture treatment requires surgical proficiency and meticulous care adhering to established treatment protocols. This approach is paramount for minimizing the risk of potentially limb- or even life-threatening complications such as fracture-related infection (FRI) in all age groups. There is a general consensus on essential measures such as wound assessment, surgical debridement and early use of antibiotics. Treatment should always be based on the correct classification of the fracture and the corresponding soft tissue injury, but needs to be adapted to the individual patient considering general health status, secondary diagnoses and currently available treatment options.
C1 [von Rueden, Christian; Wunder, Johannes; Schirdewahn, Christoph] Klinikum Weiden, Dept Trauma Surg Orthopaed & Hand Surg, D-92637 Weiden, Germany.
   [von Rueden, Christian; Augat, Peter] Paracelsus Med Univ, Inst Biomech, Salzburg, Austria.
   [Augat, Peter] BG Unfallklin Murnau, Inst Biomech, Murnau, Germany.
   [Hackl, Simon] BG Unfallklin Murnau, Dept Trauma Surg, Murnau, Germany.
C3 Paracelsus Private Medical University
RP von Rüden, C (通讯作者)，Klinikum Weiden, Dept Trauma Surg Orthopaed & Hand Surg, D-92637 Weiden, Germany.
EM christian.vonrueden@kno.ag
RI ; Augat, Peter/A-2051-2011
OI von Rüden, Christian/0000-0001-6308-8378; Augat,
   Peter/0000-0003-4805-2128
FU Osteosynthesis and Trauma Care Foundation (OTCF); Stryker
FX This paper is part of a Supplement supported by the Osteosynthesis and
   Trauma Care Foundation (OTCF) through a research grant from Stryker.
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NR 64
TC 5
Z9 8
U1 1
U2 6
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD NOV
PY 2024
VL 55
SU 6
AR 111935
DI 10.1016/j.injury.2024.111935
EA OCT 2024
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA L1T7J
UT WOS:001348621600001
PM 39482034
DA 2026-07-24
ER
PT J
AU Tian, BX
   Yang, X
   Liu, Y
   Wei, CL
   Liu, DJ
   Ren, X
   Lin, HL
AF Tian, Baoxiang
   Yang, Xiong
   Liu, Yang
   Wei, Chunlin
   Liu, Dujuan
   Ren, Xue
   Lin, Hailong
TI The application effect of autologous platelet-rich plasma combined with
   negative pressure sealing drainage technology in pressure ulcer wound
   repair
SO MEDICINE
LA English
DT Article
DE autologous platelet-rich plasma; negative pressure sealed drainage;
   pressure sores; wound repair
ID THERAPY; INJURY
AB This study aimed to evaluate the efficacy of combining autologous platelet-rich plasma (PRP) with negative pressure wound therapy (NPWT) for the repair of pressure ulcers. We included 90 patients with pressure ulcers from General Technology Gemstone Flower Healthcare Jilin City Hospital of Chemical Industry between January 2021 and December 2023. Patients were randomly assigned to either a control group or an observation group, with 45 patients in each. The control group received NPWT alone, while the observation group received a combination of PRP and NPWT. Outcomes were compared between the groups, including clinical efficacy, wound recovery time (infection control time, wound healing time, hospital stay), levels of inflammatory markers (C-reactive protein, erythrocyte sedimentation rate, white blood cell count), pain scores (numerical rating scale), Pressure Ulcer Scale for Healing scores, and incidence of complications. The observation group demonstrated a total effective rate of 95.56% (43/45), significantly higher than the control group's 80.00% (35/45) (P < .05). Additionally, the observation group had significantly shorter infection control times, wound healing times, and hospital stays (P < .05). Two weeks post-surgery, the observation group had significantly lower levels of C-reactive protein, erythrocyte sedimentation rate, and white blood cell count, as well as reduced numerical rating scale and Pressure Ulcer Scale for Healing scores (P < .05). The incidence of complications was 6.67% (3/45) in the observation group compared to 33.33% (15/45) in the control group, with a significant difference (P < .05). Combining autologous PRP with NPWT significantly improves clinical outcomes, reduces inflammatory responses, decreases pain, accelerates wound healing, and lowers complication rates in patients with pressure ulcers.
C1 [Tian, Baoxiang; Yang, Xiong; Liu, Yang; Wei, Chunlin; Liu, Dujuan; Ren, Xue; Lin, Hailong] Gen Technol Gemstone Flower Healthcare Jilin City, Dept Burns & Plast Surg, Jilin 132000, Peoples R China.
RP Lin, HL (通讯作者)，Gen Technol Gemstone Flower Healthcare Jilin City, Dept Burns & Plast Surg, Jilin 132000, Peoples R China.
EM Tianbaoxiang68@163.com; yangxiong19740503@sina.com; 573484069@qq.com;
   71671932@qq.com; 573484069@qq.com; 770534927@qq.com; 13019164447@163.com
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NR 25
TC 6
Z9 7
U1 3
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV 1
PY 2024
VL 103
IS 44
AR e39672
DI 10.1097/MD.0000000000039672
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA L2Z3R
UT WOS:001349448700031
PM 39496059
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fahrenkrog, C
   Miftode, S
   Al-Mawsheki, A
   Alfarawan, F
   Wilters, S
   Bockhorn, M
   El-Sourani, N
AF Fahrenkrog, Catharina
   Miftode, Sorin
   Al-Mawsheki, Ahmed
   Alfarawan, Fadl
   Wilters, Stella
   Bockhorn, Maximilian
   El-Sourani, Nader
TI Effect of Neoadjuvant Therapy on Endoluminal Vacuum-Assisted Closure
   Therapy (EVAC) for Anastomotic Leakage After Oesophagectomy
SO CANCERS
LA English
DT Article
DE endoluminal vacuum-assisted closure; EVAC; anastomotic leakage;
   oesophagectomy; neoadjuvant therapy; chemotherapy; chemoradiation;
   oesophageal cancer
ID SQUAMOUS-CELL CARCINOMA; COMPLICATIONS; CHEMORADIOTHERAPY; RADIATION;
   CHEMORADIATION; ADENOCARCINOMA; MORTALITY; PROGRAM; SURGERY; RISK
AB Background: Anastomotic leakage (AL) is a dreaded complication after oesophagectomy. Endoluminal vacuum-assisted closure therapy (EVAC) has been increasingly used as a first-line treatment for AL. We aimed to identify any potential adverse effects of a neoadjuvant therapy (chemotherapy (CT) or radiochemotherapy (RCT)) on EVAC. Methods: We performed a retrospective cohort study at our tertiary centre between 2013 and 2024. All patients who underwent EVAC for AL after oesophagectomy were included in this study. Parameters such as success rate, length of therapy, number of sponges needed, changes in treatment, and survival were analysed. Results: A total of 29 patients were included, 19 of whom received CT/RCT and 10 of whom received no neoadjuvant treatment (NT). There was no significant difference in patient survival (30-day survival rate CT/RCT n = 1 (5.3%) vs. NT n = 1 (10%), p = 0.632), success rate (CT/RCT n = 15 (78.9%) vs. NT n = 9 (90%), p = 0.454), and length of therapy (CT/RCT vs. NT 24.11 vs. 23.8, p = 0.681), the number of sponges required (CT/RCT vs. NT 6.26 vs. 6.6, p = 0.835), and the need for changing treatment (CT/RCT n = 5 (26.3%) vs. NT n = 1 (10%), p = 0.303). Conclusions: NT did not affect the success rate or length of therapy. Thus, we found no significant influence of CT/RCT on EVAC for AL after oesophagectomy.
C1 [Fahrenkrog, Catharina; Wilters, Stella; Bockhorn, Maximilian; El-Sourani, Nader] Carl von Ossietzky Univ Oldenburg, Univ Med Oldenburg, D-26129 Oldenburg, Germany.
   [Miftode, Sorin; Al-Mawsheki, Ahmed; Alfarawan, Fadl; Bockhorn, Maximilian] Klinikum Oldenburg AoR, Univ Klin Allgemein & Viszeralchirurg, D-26133 Oldenburg, Germany.
   [El-Sourani, Nader] Univ Klinikum Munster, Klin Allgemein Viszeral & Transplantat Chirurg, D-48149 Munster, Germany.
C3 Carl von Ossietzky Universitat Oldenburg; Klinikum Oldenburg; University
   of Munster
RP El-Sourani, N (通讯作者)，Carl von Ossietzky Univ Oldenburg, Univ Med Oldenburg, D-26129 Oldenburg, Germany.; El-Sourani, N (通讯作者)，Univ Klinikum Munster, Klin Allgemein Viszeral & Transplantat Chirurg, D-48149 Munster, Germany.
EM nader.el-sourani@ukmuenster.de
RI El-Sourani, Nader/GRO-7989-2022; Alfarawan, Fadl/NZO-4372-2025
OI El-Sourani, Nader/0000-0002-6146-7785; Al-Mawsheki,
   Ahmed/0009-0002-2079-3135; 
CR Aktories Klaus., 2022, Allgemeine und spezielle Pharmakologie und Toxikologie. Lehrbuch und Nachschlagewerk fur Studierende der Medizin, Zahnmedizin, Pharmazie und Veterinarmedizin, fur Arzte, Zahnarzte
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NR 36
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD NOV
PY 2024
VL 16
IS 21
AR 3597
DI 10.3390/cancers16213597
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA L5G3O
UT WOS:001350994600001
PM 39518039
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hu, J
   Fu, SZ
AF Hu, Jing
   Fu, Shouzhi
TI The perioperative nursing effect of VSD closed negative pressure
   drainage in the treatment of emergency traumatic wound infection
SO MEDICINE
LA English
DT Article
DE emergency trauma; perioperative period; vacuum sealing drainage closed
   negative pressure; wound infection
ID SEALING DRAINAGE
AB This study aims to explore the perioperative nursing effect of vacuum sealing drainage closed negative pressure drainage in the treatment of emergency traumatic wound infection. A total of 116 patients with trauma-related wound infection were admitted to the Department of orthopedics and skin wound at our hospital from April 2021 to October 2022 were selected as the study subjects. They were divided into an observation group and a control group, with 58 patients in each group. Patients in the control group received traditional wound debridement, while patients in the observation group underwent debridement with the addition of vacuum-sealed drainage closed negative pressure. The treatment outcomes, pain levels, various treatment indicators, and wound healing conditions of the 2 groups were compared. The overall effective rate of treatment in the observation group was 93.10%, which was significantly higher than the control group's rate of 75.86% (P < .05). The Visual Analog Scale scores of patients in both groups were compared at 1 hour after treatment and 6 hours after treatment (P > .05). However, at 12 hours and 24 hours after treatment, the Visual Analog Scale scores of patients in the observation group were significantly lower than those in the control group (P < .05). The observation group of patients had fewer changes of dressings after treatment compared to the control group (P < .05). The wound healing time, antibiotic usage duration, and hospitalization time were all shorter in the observation group than in the control group (P < .05). The Bates-Jensen scores of both groups of patients before treatment were compared (P > .05). After treatment, the Bates-Jensen scores in both groups decreased, and the observation group had lower scores than the control group (P < .05). The use of vacuum sealing drainage closure therapy in patients with emergency trauma-related wound infections can alleviate pain, reduce the frequency of dressing changes, accelerate wound healing, and improve wound healing outcomes. It is worthy of clinical promotion.
C1 [Hu, Jing; Fu, Shouzhi] Wuhan Univ, Wuhan Hosp 3, Dept ICU Emergency, Wuhan 430074, Hubei, Peoples R China.
C3 Wuhan University
RP Fu, SZ (通讯作者)，Wuhan Univ, Wuhan Hosp 3, Dept ICU Emergency, Wuhan 430074, Hubei, Peoples R China.
EM 861644139@qq.com; hjing202409@163.com
CR Alnakshabandie WMY, 2023, J INFECT DEV COUNTR, V17, P525, DOI 10.3855/jidc.17554
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NR 20
TC 2
Z9 3
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV 8
PY 2024
VL 103
IS 45
AR e40376
DI 10.1097/MD.0000000000040376
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA L7Q4L
UT WOS:001352625300021
PM 39533567
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Suludere, MA
   Malone, M
   Siah, MC
   Tarricone, A
   Coye, TL
   Najafi, B
   Lavery, LA
AF Suludere, Mehmet A.
   Malone, Matthew
   Siah, Michael C.
   Tarricone, Arthur
   Coye, Tyler L.
   Najafi, Bijan
   Lavery, Lawrence A.
TI The Infected Diabetic Foot: Does Negative Pressure Wound Therapy with
   Irrigation Reduce Bioburden and Improve Wound Healing?
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article; Early Access
DE negative pressure wound therapy; irrigation; polyhexamethylene
   biguanide; diabetic foot infection; diabetic foot wound
ID VACUUM-ASSISTED CLOSURE; BACTERIAL LOAD; INSTILLATION; AMPUTATION;
   OUTCOMES; BIOFILM; IMPACT; SALINE
AB The aim of this study was to compare the microbial loads of patients with diabetic foot infections treated with negative pressure wound therapy (NPWT) with and without irrigation with polyhexamethylene biguanide (NPWTi-P). This is a post hoc analysis of combined data of two randomized clinical trials. We evaluated people with diabetes treated with moderate and severe diabetic foot infections that required surgery. Tissue specimens were obtained after the initial surgery and following a second planned return to the operating room after 48-72 h of NPWT or NPWTi-P, prior to the second surgery. We used quantitative polymerase chain reaction (qPCR) to determine the total microbial loads (Log10 16S copies per gram of tissue). There was no difference in mean quantitative bacterial cultures among patients that received NPWT and NPWTi-P (before first surgery Log10: NPWT = 6.4 +/- 1.8, NPWTi-P = 7.5 +/- 1.7 vs before second surgery Log10: NPWT = 6.7 +/- 1.8, NPWTi-P = 7.6 +/- 1.9 p = .12). There was no difference in wound healing (59.5% vs 50.0%, p = .51) or time to heal (127 +/- 109.3 vs 143 +/- 95.9), p = .71). There were fewer re-infections in people that received traditional NPWT (28.6% vs 56.3%, p = .05).Level of Clinical Evidence: Level 1.
C1 [Suludere, Mehmet A.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr, Dept Plast Surg, 5323 Harry Hines Blvd F4 124, Dallas, TX 75390 USA.
   [Malone, Matthew] Western Sydney Univ, Sch Med, Infect Dis & Microbiol, Sydney, Australia.
   [Siah, Michael C.] Univ Texas Southwestern Med Ctr, Dept Surg, Dallas, TX USA.
   [Siah, Michael C.] Univ Texas Dallas, Dept Bioengn, Richardson, TX USA.
   [Tarricone, Arthur] Univ Texas Hlth Sci Ctr, Dept Orthopaed Surg, San Antonio, TX USA.
   [Coye, Tyler L.; Najafi, Bijan] Baylor Coll Med, Dept Surg, Houston, TX USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; Western Sydney University; University of Texas System;
   University of Texas Southwestern Medical Center; University of Texas
   System; University of Texas Dallas; University of Texas System;
   University of Texas at San Antonio; Baylor College of Medicine
RP Suludere, MA (通讯作者)，Univ Texas Southwestern Med Ctr, Dept Plast Surg, 5323 Harry Hines Blvd F4 124, Dallas, TX 75390 USA.
EM msuludere@gmail.com
RI Tarricone, Arthur/AAN-9955-2021; Najafi, Bijan/AAK-5650-2020
OI Najafi, Bijan/0000-0002-0320-8101; Lavery, Lawrence/0000-0002-7920-9952;
   Suludere, Mehmet Akif/0000-0002-2285-0909
FU American Diabetes Association; Cardinal Health
FX The authors disclosed receipt of the following fi nancial support for
   the research, authorship, and/or publication of this article: This is a
   sub analysis of combined data from two randomized clinical trials. The
   randomized clinical trials were separately funded by American Diabetes
   Association (NCT02308800) and Cardinal Health (NCT02519621). L.A.L is
   the recipient of both grants.
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NR 29
TC 1
Z9 1
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD 2024 NOV 13
PY 2024
DI 10.1177/15347346241292125
EA NOV 2024
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA L8S9U
UT WOS:001353377700001
PM 39533885
OA hybrid
DA 2026-07-24
ER
PT J
AU Sheng, X
   Hu, L
   Li, T
   Zou, Y
   Fu, HY
   Xiong, GP
   Zhu, Y
   Deng, B
   Xiong, LL
   Yin, XL
AF Sheng, Xia
   Hu, Ling
   Li, Ting
   Zou, Yi
   Fu, Hai-Yan
   Xiong, Guo-Ping
   Zhu, Yan
   Deng, Bo
   Xiong, Lei-Lei
   Yin, Xiao-Ling
TI Clinical efficacy and mechanism of the combination of autologous
   platelet-rich gel and recombinant human acidic fibroblast growth factor
   in the management of refractory diabetic foot
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetic foot; oxidative stress; pigment epithelium-derived factor;
   platelet-rich gel; vascular endothelial growth factor
AB Objective This study aims to explore the influence of combining autologous platelet-rich gel (APG) with continuous vacuum-sealed drainage (CVSD) and the exogenous recombinant human acidic fibroblast growth factor (rh-aFGF) on the healing processes of diabetic foot ulcers (DFU). The primary objective is to elucidate the complex molecular mechanisms associated with DFU, providing innovative perspectives for its treatment. Methods Ninety patients diagnosed with DFU were randomly allocated into three distinct groups. Group A underwent CVSD following wound cleansing to facilitate healing. In Group B, in addition to conventional treatment, negative pressure wound therapy was applied, and rh-aFGF was introduced into normal saline for lavage, building upon the procedures of Group A. Group C received APG along with the interventions applied in Group B. The clinical efficacy of each group was systematically observed and analyzed. Additionally, changes in plasma oxidative stress, inflammatory markers, vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) were assessed both before treatment and 14 days post-treatment. Results Following treatment, all groups exhibited commendable clinical efficacy. Group C demonstrated a superior wound healing rate, reduced frequency of dressing changes, and shorter wound healing duration (P< 0.05). Compared to baseline measurements, the levels of superoxide dismutase and PEDF increased, while malondialdehyde, VEGF, interleukin-6, interleukin-8, and monocyte chemotactic factor MCP-1 decreased in the wound tissue across all groups. Notably, Group C showed the most significant improvement in clinical efficacy and fortification of molecular mechanisms against oxidative stress (all P< 0.05). Conclusions The integrative therapeutic approach combining APG with CVSD and rh-aFGF demonstrates notable efficacy in advancing wound healing. This effectiveness is evident through the reduced frequency of dressing changes and alleviation of wound-related pain. Additionally, the treatment regimen improves the cure rate for challenging, refractory wounds. These favorable outcomes can be attributed to the reduction of oxidative stress levels, attenuation of the local inflammatory response, and the enhancement of the balance between PEDF and VEGF.
C1 [Sheng, Xia; Hu, Ling; Li, Ting; Zou, Yi; Fu, Hai-Yan; Xiong, Guo-Ping; Zhu, Yan; Deng, Bo; Xiong, Lei-Lei; Yin, Xiao-Ling] Nanchang Univ, Hosp Nanchang 1, Affiliated Hosp 3, Dept Metab & Endocrinol,Jiangxi Prov Key Lab Metab, Nanchang, Peoples R China.
C3 Nanchang University
RP Hu, L (通讯作者)，Nanchang Univ, Hosp Nanchang 1, Affiliated Hosp 3, Dept Metab & Endocrinol,Jiangxi Prov Key Lab Metab, Nanchang, Peoples R China.
EM drhu_hl1172@163.com
RI Li, Ting/JCN-8036-2023
FU Key Research and Development Projects of Jiangxi Province
   [20203BBG73053]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was funded by
   the Key Research and Development Projects of Jiangxi Province (Grant No.
   20203BBG73053).
CR Barc P, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191912818
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NR 17
TC 12
Z9 17
U1 4
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 30
PY 2024
VL 15
AR 1374507
DI 10.3389/fendo.2024.1374507
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L8X6Q
UT WOS:001353499700001
PM 39539934
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Szabo, D
   Turi, S
   Vadász, G
   Gadácsi, M
   Fazekas, G
   Javor, S
   Kasza, G
   Jancsó, G
   Benkö, L
AF Szabo, Dorottya
   Turi, Szamanta
   Vadasz, Gergely
   Gadacsi, Melinda
   Fazekas, Gabor
   Javor, Szaniszlo
   Kasza, Gabor
   Jancso, Gabor
   Benko, Laszlo
TI Prevention of vascular surgical site infections in the groin with
   negative pressure wound therapy
SO ORVOSI HETILAP
LA Hungarian
DT Article
DE negative pressure wound therapy; surgical site infection; groin
AB Introduction: The role of negative pressure wound therapy in the treatment of chronic, difficult-to-heal, infected wounds is becoming increasingly significant. The site most susceptible to infection following vascular surgery is the longitudinal incision wound in the groin. The following factors are predisposing factors for the development of wound infection: diabetes, obesity, previous surgery in the region, lower limb gangrene and ulcers. Objective: The objective of this study was to investigate whether closed incision negative pressure wound therapy reduces the incidence of surgical site infections and wound healing disorders in high-risk patients and whether closed incision negative pressure wound therapy reduces septic graft formation. Method: A total of 38 patients who met at least one of the inclusion criteria (body mass index >30, previous surgery in the same region, wound necrosis) were included in the study. The control group (n = 19) was treated with conventional wound coverage (Cosmopor E). In the closed incision negative pressure wound therapy group (n = 19), the primarily closed wound was covered with polyvinyl alcohol foam (VivanoMed White Foam) intraoperatively, then sealed with an airtight foil. Once the port of the vacuum machine had been connected, wound suction was initiated immediately (continuous suction, 100 mmHg). The duration of treatment was 7 days. Patients were followed up postoperatively at 10, 30, and 60 days. Results: In the control group, 42.1% of patients (n = 8) developed wound healing defects, and 36.8% (n = 7) developed surgical site infection. One patient underwent reoperation for septic graft formation. In the closed incision negative pressure wound therapy group, 31.6% (n = 6) of the patients developed wound healing problem, and 26.3% (n = 5) developed infection; in one case reoperation was performed due to septic graft formation. Conclusion: Regarding the primary endpoint, no notable discrepancies were observed between the examined groups. The results of this study demonstrate that closed incision negative pressure wound therapy may be advantageous over conventional wound care in obese patients and in those who have undergone previous inguinal surgery. A potential avenue for further investigation would be to implement more rigorous inclusion criteria.
C1 [Szabo, Dorottya; Turi, Szamanta; Vadasz, Gergely; Gadacsi, Melinda; Fazekas, Gabor; Javor, Szaniszlo; Kasza, Gabor; Jancso, Gabor; Benko, Laszlo] Pecsi Tudomanyegyet, Klin Kozpont, Altalanos Orvostudomanyi Kar, Ersebeszeti Klin, Pecs, Hungary.
C3 University of Pecs
RP Szabo, D (通讯作者)，Ifjusag Utja 13, H-7624 Pecs, Hungary.
EM dr.szabo.dorottya@pte.hu
CR Aref R, 2022, ORVOSI HETILAP, V163, P271, DOI 10.1556/650.2022.32369
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 15
TC 1
Z9 1
U1 2
U2 2
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0030-6002
EI 1788-6120
J9 ORVOSI HETILAP
JI Orvosi Hetilap
PD OCT
PY 2024
VL 165
IS 42
BP 1652
EP 1658
DI 10.1556/650.2024.33142
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M0H6N
UT WOS:001354445700002
PM 39427290
OA hybrid
DA 2026-07-24
ER
PT J
AU Kramer, DE
   Bharthi, R
   Myers, D
   Chang, PT
   Dabecco, R
   Xu, C
   Yu, ALXD
AF Kramer, Dallas E.
   Bharthi, Rosh
   Myers, Daniel
   Chang, Patrick
   Dabecco, Rocco
   Xu, Chen
   Yu, Alexander
TI Prophylactic closed-incisional negative pressure wound therapy following
   posterior instrumented spinal fusion: a single surgeon's experience and
   cost-benefit analysis
SO NEUROSURGICAL REVIEW
LA English
DT Article
DE Cost-benefit analysis; Negative pressure wound therapy; Spinal fusion;
   Surgical site infection; Vacuum-assisted closure
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   DEHISCENCE
AB Purpose: Surgical site infections (SSIs) following spine surgery are associated with morbidity and resource utilization. Applying prophylactic closed-incisional negative pressure wound therapy (ciNPWT) during posterior instrumented fusion has mixed results in reducing rates of wound complications and SSI. We evaluated the clinical efficacy and potential cost-savings associated with ciNPWT in high-risk patients receiving posterior instrumented spinal fusion. Methods: We retrospectively reviewed patients receiving posterior instrumented spinal fusion for any surgical indication between July 1, 2017 and December 31, 2019, and compared rates of wound dehiscence, SSI, and reoperation for wound complications between standard surgical dressings and ciNPWT. Surgical dressing selection was based on the senior author's assessment of infection risk factors. Results: A total of 229 patients (n = 85 standard surgical dressings, n = 144 ciNPWT) were included. The ciNPWT group had significantly more risk factors for wound-related complications, including older age (61.8 vs. 58.5 years, p = 0.042), diabetes mellitus (36.8% vs. 23.5%, p = 0.037), more instrumented levels (5.6 vs. 3.9, p < 0.0001), estimated blood loss (1298 vs. 998 mL, p = 0.036), and deformity was the predominant operative indication (29.9% vs. 17.7%, p = 0.040). Prophylactic ciNPWT was associated with significantly lower rates of wound dehiscence (21.5% vs. 34.1%, p = 0.036) and SSI (8.3% vs. 21.2%, p = 0.005). Number needed to treat with ciNPWT to prevent one SSI was 8 patients. The cost of preventing one SSI was $4,560. Cost-benefit analysis demonstrated a potential mean savings of $21,662 per operative SSI prevented and $270,775 per 100 patients undergoing posterior instrumented fusion with ciNPWT. Conclusions: Prophylactic ciNPWT use is a cost-effective means of reducing rates of wound dehiscence and SSI following posterior instrumented fusion.
C1 [Kramer, Dallas E.; Myers, Daniel; Dabecco, Rocco; Xu, Chen; Yu, Alexander] Allegheny Hlth Network, Dept Neurosurg, Pittsburgh, PA 15212 USA.
   [Bharthi, Rosh] Lake Erie Coll Osteopath Med, Erie, PA 16509 USA.
   [Chang, Patrick] Drexel Univ, Coll Med, Philadelphia, PA 19129 USA.
C3 Allegheny Health Network; Drexel University
RP Yu, ALXD (通讯作者)，Allegheny Hlth Network, Dept Neurosurg, Pittsburgh, PA 15212 USA.
EM alexander.yu@ahn.org
RI Bharthi, Rosh/JWO-9555-2024
OI Kramer, Dallas/0000-0002-2099-5864
FU Highmark Health (Pittsburgh, PA, United States of America)
FX Thank you to Tyson Barrett for his assistance in obtaining the costs
   data for this project. The authors thank Sarah Carey, MS, Jade Chang,
   and Jacalyn Newman, PhD, of Allegheny Health Network's Health System
   Publication Support Office (HSPSO) for their assistance in editing and
   formatting the manuscript. The HSPSO is funded by Highmark Health
   (Pittsburgh, PA, United States of America), and all work was done in
   accordance with Good Publication Practice (GPP3) guidelines
   (http://www.ismpp.org/gpp3).
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NR 25
TC 7
Z9 7
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0344-5607
EI 1437-2320
J9 NEUROSURG REV
JI Neurosurg. Rev.
PD NOV 15
PY 2024
VL 47
IS 1
AR 847
DI 10.1007/s10143-024-03083-8
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA M1Z6F
UT WOS:001355593700003
PM 39542937
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Hu, Y
   Qin, YY
   Dong, W
   Zhong, YX
   Chu, HB
AF Hu, Yuee
   Qin, Yanyan
   Dong, Wei
   Zhong, Yuxu
   Chu, Haibo
TI Complex intestinal fistula treatment and care: A case report and
   literature review
SO MEDICINE
LA English
DT Article
DE abdominal cocoon; intestinal fistula; nursing; perioperative period;
   traumatic intestinal rupture
ID ABDOMINAL COCOON SYNDROME; MANAGEMENT
AB Rationale:Abdominal cocoon is an uncommon abdominal disease. Intestinal rupture complicated with intestinal fistula rarely occurs in patients with abdominal cocoon.Patient concerns:A 51-year-old man was referred to hospital, with a 4-hour history of abdominal injuries caused by traffic accident. Intraoperatively, the small intestine in the abdominal cavity was surrounded by dense, tough, grayish-white fibrous tissue. There were the rupture of 2 sites in the ileum. The ileum was anastomosed side-to-side using a cutting and closing device. The patient was postoperatively transferred to the intensive care unit and received ventilator-assisted breathing, along with anti-infection and supportive treatments. On the 10th day after surgery, grass green turbid fluid of approximately 150 mL was extracted from the abdominal drainage tube. The secondary laparotomy was performed on the 12th day post-surgery, revealing a 1.5 cm diameter fistula at the end of the ileum.Intervention and outcomes:Nursing strategies included ensuring optimal mechanical ventilation for oxygenation, utilizing Li's double cannula for continuous abdominal irrigation and negative pressure drainage to prevent abdominal abscess formation, emphasizing the importance of enteral nutrition, implementing direct suture treatment to manage retrograde infection and expedite stoma healing, and employing Li's double cannula and vacuum-assisted closure technique to promote incision healing. After 48 days secondary post-surgery, the incision was fully healed, and the patient was discharged home with the stoma bag. Five months later, he was readmitted to the hospital, and the stoma was reversed.Lessons:Intestinal fistula poses a remarkable challenge after abdominal cocoon surgery, typically manifesting 4 to 5 days postoperatively. However, in this case, it occurred on the 10th day, highlighting the critical role of vigilant monitoring of drainage fluid color and volume in postoperative care. Navigating the complex management of intestinal rupture in abdominal cocoon necessitates a more efficacious approach, highlighting the importance of accumulating comprehensive nursing expertise through such cases.
C1 [Hu, Yuee; Qin, Yanyan; Dong, Wei; Chu, Haibo] Tongji Univ, Shanghai East Hosp, Dept Gen Surg, Jiaozhou Branch, Qingdao, Peoples R China.
   [Zhong, Yuxu] Inst Toxicol & Pharmacol, State Key Lab Toxicol & Med Countermeasures, Beijing, Peoples R China.
C3 Tongji University
RP Chu, HB (通讯作者)，Tongji Univ, Shanghai East Hosp, Dept Gen Surg, Jiaozhou Branch, Qingdao, Peoples R China.; Chu, HB (通讯作者)，Tongji Univ, Shanghai East Hosp, Dept Gen Surg, Jiaozhou Branch, Jiaozhou 266300, Peoples R China.
EM huyuee33776@163.com; 13606302128@162.com; dongwei891006@163.com;
   yuxuzhong2008@aliyun.com; haibochuwf@163.com
FU Military Logistic Project of China [AWS17J008]; Medical and health
   Scientific research guidance Project of Qingdao [2023-WJZD055]
FX This work was funded by Military Logistic Project of China (AWS17J008),
   and 2023 Medical and health Scientific research guidance Project of
   Qingdao (2023-WJZD055).
CR Adams SC, 2022, NUTR CLIN PRACT, V37, P493, DOI 10.1002/ncp.10861
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   Zhao TT, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008367.pub4
NR 29
TC 1
Z9 1
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV 15
PY 2024
VL 103
IS 46
AR e40511
DI 10.1097/MD.0000000000040511
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M7A5I
UT WOS:001359023400002
PM 39560576
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Srinivas, S
   Coleman, JR
   Baselice, H
   Scarlet, S
   Tracy, BM
AF Srinivas, Shruthi
   Coleman, Julia R.
   Baselice, Holly
   Scarlet, Sara
   Tracy, Brett M.
TI Open or Closed? Management of Skin Incisions After Emergency General
   Surgery Laparotomies
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Emergency general surgery; Hollow viscus perforation; Laparotomy; Skin
   management; Surgical site infection; Wound class
ID SURGICAL SITE INFECTION; PRESSURE WOUND THERAPY; RISK-FACTORS;
   COLORECTAL SURGERY; TRAUMA LAPAROTOMY; RANDOMIZED-TRIAL; CLOSURE
AB Introduction: We sought to determine if there was a relationship between skin management and surgical site infections (SSIs) among patients undergoing a laparotomy for emergency general surgery (EGS). We hypothesize that skin closure technique is not associated with SSI. Methods: We performed a retrospective review of adult patients (>18 y) who underwent an exploratory laparotomy for EGS conditions within 6 h of surgical consultation from 2015 to 2019. Patients whose fascia was not closed during the index operation were excluded. Patients were divided into groups: open skin (OS) and closed skin (CS). OS included negative pressure wound therapy or wet-to-dry gauze; CS included closure with staples or sutures. Our primary outcome was the rate of SSI. Results: The cohort comprised 388 patients: 42.3% OS (n = 164) and 57.7% CS (n = 224). The OS group had greater rates of systemic inflammatory response syndrome [SIRS] (54.9% versus 27.7%, P < 0.0001), hollow viscus perforation [HVP] (71.3% versus 20.5%, P < 0.0001), and peritoneal drains (51.2% versus 17.9%, P < 0.0001). Rates of OS management increased as wound class severity increased (0% [I] versus 12.2% [II] versus 15.9% [III] versus 72% [IV], P < 0.0001). The SSI rate for the cohort was 3.6% (n = 14); there was no difference in SSI rates (2.7% versus 4.9%, P = 0.3) between the CS or OS groups. Median length of stay was longer for the OS group (10 d versus 6.5 d, P < 0.0001). Independent predictors of OS management were SIRS (adjusted odds ratio [aOR] 1.72, 95% confidence interval [CI] 1.01-2.93, P = 0.04), HVP (aOR 2.03, 95% CI 1.09-3.8, P = 0.03), and class III/IV wounds (aOR 8.65, 95% CI 4.43-16.89, P < 0.0001). Conclusions: OS management occurs more often in patients with SIRS, HVP, and dirty wounds after EGS laparotomies. However, we found no difference in SSI between groups, suggesting that skin closure can be considered in contaminated or dirty wounds. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Srinivas, Shruthi; Coleman, Julia R.; Baselice, Holly; Scarlet, Sara; Tracy, Brett M.] Ohio State Univ, Wexner Med Ctr, Dept Surg, Columbus, OH USA.
C3 University System of Ohio; Ohio State University
RP Tracy, BM (通讯作者)，Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Trauma Crit Care & Burn, 395 W 12th Ave, Columbus, OH 43210 USA.
EM brett.tracy@osumc.edu
OI Tracy, Brett/0000-0002-1469-3608; Srinivas, Shruthi/0000-0001-6246-7843
CR Acker A, 2018, J SURG RES, V232, P450, DOI 10.1016/j.jss.2018.05.083
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   Shen P, 2017, J AM COLL SURGEONS, V224, P726, DOI 10.1016/j.jamcollsurg.2016.12.028
   Teixeira PG, 2012, ANN SURG, V256, P538, DOI 10.1097/SLA.0b013e318265ea13
   Velmahos GC, 2002, AM SURGEON, V68, P795
   Watanabe A, 2008, SURG TODAY, V38, P404, DOI 10.1007/s00595-007-3637-y
   Watanabe M, 2014, SURG INFECT, V15, P256, DOI 10.1089/sur.2012.154
   Wiik H, 2001, CYTOKINE, V14, P188, DOI 10.1006/cyto.2001.0870
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NR 33
TC 2
Z9 2
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD DEC
PY 2024
VL 304
BP 190
EP 195
DI 10.1016/j.jss.2024.10.026
EA NOV 2024
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA N0A2T
UT WOS:001361056500001
PM 39551013
DA 2026-07-24
ER
PT J
AU Qian, K
   Bao, WX
   Zuo, N
   Wang, S
   Ding, W
AF Qian, Kun
   Bao, Wen-Xiu
   Zuo, Na
   Wang, Shuai
   Ding, Wei
TI The synergistic effects of platelet-rich plasma and negative pressure
   wound therapy in cavitary infected wounds: a single-centre experience
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Cavitary wounds; infection; negative pressure wound therapy;
   platelet-rich plasma; wound management; wound healing
ID EFFICACY; GEL; METAANALYSIS
AB Objective To evaluate the efficacy of the combined application of platelet-rich plasma (PRP) and negative pressure wound therapy (NPWT) in cavitary infected wounds, in addition to the parameter settings of NPWT.Methods The outcomes of patients with cavitary wounds who received debridement with either PRP plus NPWT (PRP group) or NPWT alone (controls) as part of their treatment protocol were retrospectively compared by examining preoperative and postoperative data on high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC) count, neutrophil percentage, bacterial cultures, pain (measured using visual analogue scale [VAS] scores), postoperative hospitalization duration, and effective hospitalization days.Results A total of 24 patients were included (11 who received PRP plus NPWT and 13 who received NPWT alone). Postoperative hs-CRP levels, ESR, VAS scores, and effective hospitalization days were found to be significantly reduced in the PRP group versus controls. Moreover, the PRP group exhibited a significantly elevated rate of bacterial culture conversion at postoperative day 3.Conclusions The integration of surgical debridement with PRP and NPWT in the management of infected cavitary wounds may expedite infection containment and bacterial eradication, stimulate granulation tissue formation, and facilitate cavity closure, offering a novel and uncomplicated approach to wound healing.
C1 [Qian, Kun; Bao, Wen-Xiu; Wang, Shuai; Ding, Wei] First Affiliated Hosp, Wannan Med Coll, Dept Burn & Plast Surg, 2 Zhe ShanWest Rd, Wuhu 241000, Anhui, Peoples R China.
   [Zuo, Na] First Affiliated Hosp, Wannan Med Coll, Dept Otolaryngol Head & Neck Surg, Wuhu, Anhui, Peoples R China.
C3 Wannan Medical College; Wannan Medical College
RP Ding, W (通讯作者)，First Affiliated Hosp, Wannan Med Coll, Dept Burn & Plast Surg, 2 Zhe ShanWest Rd, Wuhu 241000, Anhui, Peoples R China.
EM 13956174927@163.com
OI Qian, Kun/0009-0003-9247-2901
FU Construction of Standardized Treatment System for Acute Wounds in
   Southern Anhui Province, China; Blood Transfusion Department of the
   First Affiliated Hospital of Wannan Medical College
FX The authors are grateful to the patients and their families who
   participated in this study, as well as the staff who were not at the
   centre. We thank Dr Tao Yuqi of the Blood Transfusion Department of the
   First Affiliated Hospital of Wannan Medical College for her work in
   venous blood collection.
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NR 30
TC 1
Z9 1
U1 2
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD NOV
PY 2024
VL 52
IS 11
AR 03000605241300064
DI 10.1177/03000605241300064
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA N0R4G
UT WOS:001361502400001
PM 39579349
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Heuvelings, DJI
   van der Horst, J
   Pelzer, F
   Aarts, F
   Engelen, S
AF Heuvelings, Danique J. I.
   van der Horst, Jishmael
   Pelzer, Fanny
   Aarts, Frits
   Engelen, Sanne
TI Massive Localized Lymphedema, Wound Care Without Major Surgical
   Excision: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE maggot debridement therapy; massive localized lymphedema; obesity;
   pseudosarcoma; soft tissue tumor; wound therapy
AB Massive localized lymphedema (MLL) is a benign overgrowth of lymphoproliferative tissue that is primarily observed in adults with class III obesity. Patients present with a painless mass that has usually been present for a considerable period. Consultation of a healthcare professional typically takes place when MLL-related complaints interfere with daily living. Massive localized lymphedema is often termed "pseudosarcoma" due to its clinical similarity to sarcoma. Surgical excision is necessary to improve mobility, prevent recurrent infections, and rule out malignancy, but can be high-risk for individuals with class III obesity and multiple comorbidities. In this report, the authors present the case of a 47-year-old woman with a body mass index of 73 kg/m2 and MLL of the right medial thigh. She was successfully diagnosed and managed by local necrosectomy, wound debridement, maggot debridement therapy, and negative-pressure wound therapy by using a vacuum-assisted closure device. The diagnosis of MLL can be challenging because of its similarity to sarcoma; its pathogenesis and management are not completely elucidated. Despite surgery being the best described treatment, such an intervention itself can be challenging because patients often have multiple comorbidities and delayed diagnosis. The authors recommend that clinicians should consider nonsurgical treatment of MLL in high-risk patients who have necrotic wounds with fluid loss. The use of less invasive methods such as maggot debridement therapy followed by negative-pressure wound therapy can be useful in high-risk patients.
C1 [Heuvelings, Danique J. I.; Engelen, Sanne] Maastricht Univ, Med Ctr, Dept Surg, Maastricht, Netherlands.
   [Heuvelings, Danique J. I.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands.
   [van der Horst, Jishmael; Pelzer, Fanny; Aarts, Frits] VieCuri Med Ctr, Dept Surg, Venlo, Netherlands.
C3 Maastricht University; Maastricht University; Maastricht University
   Medical Centre (MUMC); VieCuri Medical Center
RP Heuvelings, DJI (通讯作者)，Maastricht Univ, Med Ctr, Dept Surg, Maastricht, Netherlands.; Heuvelings, DJI (通讯作者)，Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands.
EM danique.heuvelings@maastrichtuniversity.nl;
   jischmael.vanderhorst@mumc.nl; fanny.pelzer@mumc.nl; faarts@viecuri.nl;
   sanne.engelen@mumc.nl
OI Heuvelings, Danique/0000-0001-5352-8704
CR Asch S, 2008, J AM ACAD DERMATOL, V59, pS109, DOI 10.1016/j.jaad.2008.04.009
   Chopra K, 2015, ANN PLAS SURG, V74, P126, DOI 10.1097/SAP.0b013e31828bb332
   Dyroff S, 2020, SKELETAL RADIOL, V49, P815, DOI 10.1007/s00256-020-03373-4
   Evans RJ, 2011, CAN J PLAST SURG, V19, pE30
   Farshid G, 1998, AM J SURG PATHOL, V22, P1277, DOI 10.1097/00000478-199810000-00013
   Gogiya B Sh, 2020, Khirurgiia (Mosk), P116, DOI [10.17116/hirurgia2020101116, 10.17116/hirurgia2020101116]
   Hou LG, 2019, ANN MED SURG, V47, P53, DOI 10.1016/j.amsu.2019.10.002
   Jabbar F, 2015, AM J SURG, V209, P584, DOI 10.1016/j.amjsurg.2014.12.010
   Lobato RC, 2019, INT J SURG CASE REP, V59, P84, DOI 10.1016/j.ijscr.2019.05.022
   Maclellan RA, 2017, J AM COLL SURGEONS, V224, P212, DOI 10.1016/j.jamcollsurg.2016.10.047
   Manduch M, 2009, J CLIN PATHOL, V62, P808, DOI 10.1136/jcp.2009.066555
   Moore E, 2018, ANN PLAS SURG, V81, P75, DOI 10.1097/SAP.0000000000001475
   Porrino Jack, 2016, Radiol Case Rep, V11, P391, DOI 10.1016/j.radcr.2016.08.009
   Wu D, 2000, HUM PATHOL, V31, P1162, DOI 10.1053/hupa.2000.17987
   Yeom BW, 2022, ANZ J SURG, V92, P2382, DOI 10.1111/ans.17494
NR 15
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV-DEC
PY 2024
VL 37
IS 11-12
BP 8
EP 8
DI 10.1097/ASW.0000000000000222
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA N0V4X
UT WOS:001361608300006
PM 39792525
OA Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Bulic, K
   Gatin, L
AF Bulic, Kresimir
   Gatin, Lucija
TI Bagging an Extremity for Negative-Pressure Wound Therapy: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE bagging; degloving; negative-pressure wound therapy; upper extremity
ID VACUUM-ASSISTED CLOSURE
AB Negative-pressure wound therapy (NPWT) is used to promote wound closure or to prepare a wound for definite coverage. However, the anatomy of the hand makes it difficult to apply dressings that require an airtight seal. In this report, the authors describe the case of a patient with an extensive defect of his right hand and forearm who was treated with a free fibula osteocutaneous flap transfer. The remaining defect was covered with a split-thickness skin graft following NPWT. An airtight seal was achieved by placing the whole extremity in a sterile bag and sealing it proximal to the defect. The authors present a simple and innovative way of treating defects on upper extremities with NPWT with excellent results.
C1 [Bulic, Kresimir] Univ Hosp Ctr Zagreb, Dept Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.
   [Bulic, Kresimir] Univ Zagreb, Dept Surg, Sch Med, Zagreb, Croatia.
   [Gatin, Lucija] Univ Hosp Ctr Zagreb, Dept Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.
C3 University of Zagreb; University of Zagreb Hospital; University of
   Zagreb; University of Zagreb; University of Zagreb Hospital
RP Bulic, K (通讯作者)，Univ Hosp Ctr Zagreb, Dept Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.; Bulic, K (通讯作者)，Univ Zagreb, Dept Surg, Sch Med, Zagreb, Croatia.
EM kbulic@kbc-zagreb.hr; lucijabradic@gmail.com
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Capobianco Claire M, 2009, Clin Podiatr Med Surg, V26, P619, DOI 10.1016/j.cpm.2009.08.002
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Foo A, 2009, J PLAST RECONSTR AES, V62, pE129, DOI 10.1016/j.bjps.2008.05.030
   Hasegawa K, 2013, ACTA MED OKAYAMA, V67, P271
   Miller Christine, 2012, J Am Coll Clin Wound Spec, V4, P61, DOI 10.1016/j.jccw.2013.11.002
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Niu XF, 2017, ORTHOP TRAUMATOL-SUR, V103, P461, DOI 10.1016/j.otsr.2017.01.008
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
   Shine J, 2019, INT WOUND J, V16, P960, DOI 10.1111/iwj.13128
NR 11
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV-DEC
PY 2024
VL 37
IS 11-12
BP 10
EP 10
DI 10.1097/ASW.0000000000000224
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA N0V4X
UT WOS:001361608300021
PM 39792528
DA 2026-07-24
ER
PT J
AU Pontes, L
   de Azevedo, JS
   Secco, IL
   Pereira, HP
   Vieira, SCM
   Afonso, RQ
AF Pontes, Leticia
   de Azevedo, Juliana Szreider
   Secco, Izabela Linha
   Pereira, Higor Pacheco
   Vieira, Solange Cristina Moreira
   Afonso, Regiane Queiroz
TI Negative pressure therapy in pediatric patient with surgical site
   infection: experience report
SO REVISTA DA ESCOLA DE ENFERMAGEM DA USP
LA English
DT Article
DE Surgical Wound Infection; Negative-Pressure Wound Therapy; Wound
   Healing; Nursing Care; Pediatrics
ID TOXIC MEGACOLON; WOUND THERAPY; MANAGEMENT; CHILDREN
AB Objective: To describe the use of negative pressure wound therapy and hydrofiber dressing with silver in a pediatric patient with a hard-to-heal surgical wound infection. Method: This is a descriptive professional experience report on the use of conventional dressings and negative pressure wound therapy in a pediatric patient with a surgical wound infection. It was developed in 2023 at a Public Health Service that is a reference in the care of pediatric patients in the state of Paran & aacute;. Results: The surgical wound dehiscence started 12 days after peritoneostomy. Initially, the wound was treated with hydrofiber dressing with silver for 22 days and subsequently, negative pressure wound therapy was used for 15 days, regenerating the wound. Conclusion: Negative pressure wound therapy in pediatrics proved to be safe, effective and efficient for the treatment of complex wounds and corroborated the skin regeneration process, as did hydrofiber dressing with silver.
C1 [Pontes, Leticia; de Azevedo, Juliana Szreider; Secco, Izabela Linha; Pereira, Higor Pacheco] Univ Fed Parana, Programa Posgrad Prat Cuidado Saude, Curitiba, PR, Brazil.
   [Pontes, Leticia; de Azevedo, Juliana Szreider; Secco, Izabela Linha; Vieira, Solange Cristina Moreira; Afonso, Regiane Queiroz] Hosp Infantil Doutor Waldemar Monastier, Campo Largo, PR, Brazil.
C3 Universidade Federal do Parana
RP de Azevedo, JS (通讯作者)，Via Veneza 471,Casa 16, BR-83607050 Campo Largo, PR, Brazil.
EM julianaszreider@gmail.com
RI ; Pontes, Letícia/AAX-4668-2021
OI Szreider de Azevedo, Juliana/0000-0003-2817-8655; Afonso,
   Regiane/0000-0002-0087-1653; Pontes, Letícia/0000-0002-6766-7550;
   PEREIRA, HIGOR/0000-0001-5112-1118
CR Astasio-Picado A, 2022, J PERS MED, V12, DOI 10.3390/jpm12111813
   Bates-Jensen BM, 2019, WOUND REPAIR REGEN, V27, P386, DOI 10.1111/wrr.12714
   Brasil. Agencia Nacional de Vigilancia Sanitaria, 2017, Criterios diagnosticos de infeccao relacionada a assistencia a saude, V2
   Carvalho CD, 2022, ACTA CIR BRAS, V37, DOI 10.1590/acb370801
   Casarin ST, 2021, J Nutr Health, V11, DOI [10.15210/jonah.v11i4.21998, DOI 10.15210/JONAH.V11I4.21998]
   Desai J, 2020, CLIN EXP GASTROENTER, V13, P203, DOI 10.2147/CEG.S200760
   Drake TM, 2020, BMJ GLOB HEALTH, V5, DOI 10.1136/bmjgh-2020-003429
   Gomes João, 2021, NTQR, V8, P606
   Goswami AG, 2023, EUR J MED RES, V28, DOI 10.1186/s40001-023-01121-7
   Irabien M, 2021, REV ESP ENFERM DIG, V113, P189, DOI 10.17235/reed.2020.7228/2020
   Leaper DJ, 2017, J HOSP INFECT, V95, P135, DOI 10.1016/j.jhin.2016.12.016
   Luze H, 2022, J CLIN MED, V11, DOI 10.3390/jcm11226634
   Martins T, 2020, ESTIMA, Braz. J EnterostomalTher, V18, P1220, DOI [10.30886/estima.v18.848PT, DOI 10.30886/ESTIMA.V18.848PT]
   Martins Tatiana, 2018, Texto contexto - enferm., V27, pe2790016, DOI [10.1590/0104-070720180002790016, 10.1590/0104-070720180002790016]
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   O'Brien BC, 2014, ACAD MED, V89, P1245, DOI 10.1097/ACM.0000000000000388
   Oliveira MD, 2020, REV BRAS ENFERM, V73, DOI 10.1590/0034-7167-2019-0331
   Oropallo A, 2021, J WOUND CARE, V30, P854, DOI 10.12968/jowc.2021.30.10.854
   Rather MA, 2021, BRAZ J MICROBIOL, V52, P1701, DOI 10.1007/s42770-021-00624-x
   Santos SV, 2014, REV ESC ENFERM USP, V48, P985
   Santosa KB, 2020, J SURG RES, V254, P197, DOI 10.1016/j.jss.2020.04.025
   Santosa KB, 2019, J SURG RES, V235, P560, DOI 10.1016/j.jss.2018.10.043
   Secco IL, 2021, REV ESC ENFERM USP, V55, DOI 10.1590/S1980-220X2020047203769
   Silva AL, 2020, J Enterostomal Ther, V18, P1820, DOI [10.30886/estima.v18.888PT, DOI 10.30886/ESTIMA.V18.888PT]
   Ul Hassan SW, 2022, BMJ CASE REP, V15, DOI 10.1136/bcr-2022-249801
   Wagner JC, 2021, LANGENBECK ARCH SURG, V406, P2479, DOI 10.1007/s00423-021-02221-w
NR 26
TC 0
Z9 1
U1 1
U2 4
PU UNIV SAO PAOLO
PI CERQUERA CESAR
PA AV  DR ENEAS DE CARVALHO AGUIAR, 419, CERQUERA CESAR, SP 05403-000,
   BRAZIL
SN 0080-6234
EI 1980-220X
J9 REV ESC ENFERM USP
JI Rev. Esc. Enferm. USP
PY 2024
VL 58
AR e20240077
DI 10.1590/1980-220X-REEUSP-2024-0077en
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA N1E0W
UT WOS:001361835500001
PM 39589153
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Philip, EF
   Rajandram, R
   Zuber, M
   Khong, TL
   Roslani, AC
AF Philip, Eleanor Felsy
   Rajandram, Retnagowri
   Zuber, Mariana
   Khong, Tak Loon
   Roslani, April Camilla
TI Prophylactic PICO◊ dressing shortens wound dressing
   requirements post emergency laparotomy (EL-PICO◊ trial)
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Emergency laparotomy; Negative pressure wound therapy; PICO lozenge
   dressing; Surgical site infection
ID SURGICAL SITE INFECTIONS; THERAPY; SURGERY; INCISIONS
AB Background Surgical site infection (SSI) is a very common complication of emergency laparotomy and causes significant morbidity. The PICO lozenge device delivers negative pressure wound therapy (NPWT) to closed incisions, with some studies suggesting a role for prevention of SSI in heterogenous surgical populations. We aimed to compare SSI rates between patients receiving PICO lozenge versus conventional dressing post-emergency laparotomy. Secondary objectives were to observe seroma and dehiscence rates, length of stay, days on dressing and patients' wound experience. Methods This double blinded randomized controlled trial was conducted in University Malaya Medical Centre between October 2019 and March 2022. Patients undergoing emergency laparotomy requiring incisions less than 35 cm were included. Statistical analysis was performed using chi 2 test for categorical variables, independent T-test or Mann-Whitney U were used for parametric or non-parametric data respectively besides logistic regression. P values of < 0.05 were considered to be significant. Results Ninety-six patients were analyzed (47 interventions, 49 controls). The duration on dressing was more consistent in the intervention arm (PICO lozenge) versus control arm [9.78 +/- 10.20 vs 17.78 +/- 16.46 days, P < 0.001]. There was a trend towards lower SSI [14.3 vs 4.3%, P = 0.09], dehiscence [27.1 vs 10.6%, P = 0.07] and seroma [40.8 vs 23.4%, P = 0.08] rates in the intervention arm but this did not reach statistical significance. Length of stay [9 (IQR: 6-14) vs 11 (IQR: 6-22.5) days, P = 0.18] was fairly similar between the two arms, but more patients were very satisfied with PICO lozenge compared to the conventional dressing [80% vs 57.1%, P = 0.03]. Conclusion The use of NPWT in emergency laparotomy improves patients wound care experience, and was associated with trends towards fewer wound related complications. Cost effectiveness needs to be explored in order to further validate its use in the emergency setting, especially for patients with additional risk for SSI.<br /> Trial registration National Medical Research Registry (NMRR): NMRR-20-1975-55222.
C1 [Philip, Eleanor Felsy; Rajandram, Retnagowri; Zuber, Mariana; Khong, Tak Loon; Roslani, April Camilla] Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya
RP Roslani, AC (通讯作者)，Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia.
EM april@ummc.edu.my
RI Rajandram, Retnagowri/E-4709-2010; Roslani, April/B-8245-2010; Khong,
   Tak/S-4746-2017
OI Rajandram, Retnagowri/0000-0001-5247-2817; 
FU University Malaya Specialist Centre (UMSC) C.A.R.E Fund; Department of
   Surgery, Faculty of Medicine, Universiti Malaya
FX The authors would like to thank colleagues from the Department of
   Surgery, Faculty of Medicine, Universiti Malaya for their support in the
   completion of this study. The authors would also like to thank Nordiana
   Mohd Hashan, Nuraini Thammili (nurses) and Nik Nadia Nik Mohd Nasir
   (study coordinator), Kartheeni Nair Achuthan (RA).
CR Abdallah DY, 2013, EUR SPINE J, V22, P2800, DOI 10.1007/s00586-013-2890-6
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   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Karlakki SL, 2016, BONE JOINT RES, V5, P328, DOI 10.1302/2046-3758.58.BJR-2016-0022.R1
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NR 26
TC 4
Z9 4
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD NOV 22
PY 2024
VL 19
IS 1
AR 38
DI 10.1186/s13017-024-00560-9
PG 11
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA N1Z5B
UT WOS:001362397100001
PM 39578859
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Myers, BA
AF Myers, Beth A.
TI Negative Pressure Wound Therapy With Instillation as an Early
   Intervention for Extensive Wounds From Necrotizing Fasciitis
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Abscess; Bacterial infection wounds; Necrotizing fasciitis; Necrotizing
   infection
AB BACKGROUNDMs. S was a 50-year-old woman hospitalized with necrotizing fasciitis from a labial abscess. After several surgical interventions wound debridements were performed consecutively for 6 days. She was left with extensive full thickness tissue destruction of her abdomen, bilateral groin areas, and complete displacement of skin over her mons pubis. Wounds related to necrotizing fasciitis can be especially challenging to manage, especially when the perineal region is involved. Due to the location of such wounds, it can be difficult to maintain dressings, including negative pressure wound therapy with instillation devices (NPWTi). Ms. S. also had a history of uncontrolled diabetes mellitus, which can hinder wound healing.CASEThe Wound, Ostomy and Continence (WOC) nurse was consulted on day 6 of Ms. S's admission, for application of NPWTi. Complex NPWTi dressings were completed in the operating room (OR), 2 times weekly for 2 weeks. When Ms. S was transferred from the intensive care unit to the surgical unit, NPWT dressings with instillation were used but later converted to standard NPWT, changed twice weekly by the WOC nurse. Dressings were changed at the bedside until day 29 of her admission.CONCLUSIONThe management of Ms. S's extensive wounds was successful, and her wounds were closed by plastic surgery on day 29 of her admission. Ms. S was the first patient at our hospital with extensive wounds from necrotizing fasciitis to undergo surgical closure of her wounds during the same hospital admission.
C1 [Myers, Beth A.] Wellspan York Hosp, Trauma Crit Care Wound NP, 1001 South George St, York, PA 17403 USA.
RP Myers, BA (通讯作者)，Wellspan York Hosp, Trauma Crit Care Wound NP, 1001 South George St, York, PA 17403 USA.
EM bmyers@wellspan.org
RI /AAV-2635-2021
CR Amin N, 2023, J WOUND OSTOMY CONT, V50, P203, DOI 10.1097/WON.0000000000000967
   CDC Centers for Disease Control and Prevention, CDC 24/7 Saving Lives. Protecting PeopleTM. The National Diabetes Statistics Report, 2020. Estimates of Diabetes and Its Burden in the United States
   Crumley C, 2021, J WOUND OSTOMY CONT, V48, P199, DOI 10.1097/WON.0000000000000760
   DeGenova Daniel T, 2023, Cureus, V15, pe36576, DOI [10.7759/cureus.36576, 10.7759/cureus.36576]
   Wang GQ, 2023, INT WOUND J, V20, P1739, DOI 10.1111/iwj.13989
NR 5
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD NOV-DEC
PY 2024
VL 51
IS 6
BP 499
EP 506
DI 10.1097/WON.0000000000001101
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA N4P5X
UT WOS:001364179300006
PM 39588820
DA 2026-07-24
ER
PT J
AU Liu, X
   Zhao, P
   Wu, XZ
   Zhao, YW
   Zhou, FF
   Luo, Y
   Jia, XL
   Zhong, W
   Xing, M
   Lyu, G
AF Liu, Xing
   Zhao, Peng
   Wu, Xiaozhuo
   Zhao, Yawei
   Zhou, Feifan
   Luo, Ying
   Jia, Xiaoli
   Zhong, Wen
   Xing, Malcolm
   Lyu, Guozhong
TI Negative Pressure Smart Patch to Sense and Heal the Wound
SO ADVANCED SCIENCE
LA English
DT Article
DE drug delivery; glucose-sensing; microspheres; pH-sensing; wound
   monitoring
ID PH VALUE; THERAPY; INFECTION; REPAIR; MECHANISM; DRESSINGS; HYDROGEL;
   IMPACT
AB Negative pressure wound therapy (NPWT) offers significant advantages in terms of rate and time for healing through generating sub-vacuum to draw out inflammatory exudate and promote wound closure. However, continuous drainage probably leads to healing delay due to the lack of information about the real status of the wound bed and the potential risk of infection. To address this concern, printed Negative Pressure Smart Patch (NPSP) is reported by integrating smart real-time sensing acidity (infection) and glucose, and anti-infection into NPWT systems. In addition, NPSP delivers vancomycin through chitosan porous microspheres under negative pressure to modulate wound healing. Compared with NPWT, NPSP projects a promising approach to removing bacteria, reducing local inflammation, and accelerating healing in a short period of time.
C1 [Liu, Xing; Zhao, Peng; Zhou, Feifan; Luo, Ying; Jia, Xiaoli; Lyu, Guozhong] Jiangnan Univ, Affiliated Hosp, Engn Res Ctr, Minist Educ Wound Repair Technol, Wuxi 214000, Peoples R China.
   [Liu, Xing; Zhou, Feifan; Luo, Ying; Jia, Xiaoli; Lyu, Guozhong] Jiangnan Univ, Wuxi Sch Med, Wuxi 214000, Peoples R China.
   [Wu, Xiaozhuo; Xing, Malcolm] UNIV MANITOBA, DEPT MECH ENGN, WINNIPEG, MB R3T 2N2, Canada.
   [Zhao, Yawei; Zhong, Wen] Univ Manitoba, Dept Biosyst Engn, Winnipeg, MB R3T 2N2, Canada.
C3 Jiangnan University; Jiangnan University; University of Manitoba;
   University of Manitoba
RP Lyu, G (通讯作者)，Jiangnan Univ, Affiliated Hosp, Engn Res Ctr, Minist Educ Wound Repair Technol, Wuxi 214000, Peoples R China.; Lyu, G (通讯作者)，Jiangnan Univ, Wuxi Sch Med, Wuxi 214000, Peoples R China.; Xing, M (通讯作者)，UNIV MANITOBA, DEPT MECH ENGN, WINNIPEG, MB R3T 2N2, Canada.
EM malcolm.xing@umanitoba.ca; luguozhong@jiangnan.edu.cn
RI Jia, Xiaoli/OZE-4908-2025; Wu, Xiaozhuo/ODM-7515-2025; Zhou,
   Feifan/C-6861-2013
OI xing, malcolm/0000-0002-3547-0462; 刘, 星/0009-0009-2475-9736; Zhao,
   Peng/0009-0001-0684-6088
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NR 73
TC 8
Z9 9
U1 13
U2 57
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
EI 2198-3844
J9 ADV SCI
JI Adv. Sci.
PD JAN
PY 2025
VL 12
IS 3
AR 2408077
DI 10.1002/advs.202408077
EA NOV 2024
PG 15
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA U5Z5A
UT WOS:001364596900001
PM 39605188
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Khashkhusha, A
   Butt, S
   Abdelghaffar, M
   Wang, WL
   Rajananthanan, A
   Roy, S
   Khurshid, BN
   Zeinah, M
   Harky, A
AF Khashkhusha, Arwa
   Butt, Sundas
   Abdelghaffar, Mariam
   Wang, William
   Rajananthanan, Asveny
   Roy, Sakshi
   Khurshid, Bakht Noor
   Zeinah, Mohamed
   Harky, Amer
TI Sternal Wound Reconstruction Following Deep Sternal Wound Infection:
   Past, Present and Future: A Literature Review
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Review
DE deep sternal wound reconstruction; wound infection; multidisciplinary
   team; infection; flaps; surgical intervention; reconstruction; plastic
   surgery
ID VACUUM-ASSISTED CLOSURE; MYOCUTANEOUS ADVANCEMENT FLAPS; PECTORALIS
   MAJOR MUSCLE; STERNOTOMY WOUNDS; REDON CATHETERS; OMENTAL FLAP;
   RISK-FACTORS; ROUTINE USE; MANAGEMENT; COMPLICATIONS
AB This literature review critically examines the historical, current, and prospective dimensions of sternal wound reconstruction in the specific context of deep sternal wound infection (DSWI), aiming to enhance patient outcomes and optimise surgical techniques. Preventive measures, including prophylactic antibiotic administration and surgical site preparation, are crucial in reducing the incidence of DSWI. Effective management necessitates a multidisciplinary approach encompassing surgical debridement, drainage, and sternum repair utilising diverse procedures in conjunction with antibiotic therapy. Traditional approaches to managing DSWI involved closed irrigation and drainage techniques. While these methods exhibited certain advantages, they also exhibited limitations and varying degrees of success. The current care paradigms emphasise prophylactic antibiotic administration and surgical interventions like closed suction and irrigation, vacuum-assisted closure, and flap reconstruction. Future advancements in surgical techniques and technology hold promise for further enhancing sternal wound reconstruction. This review separates and emphasises the distinct roles of prophylaxis, antibiotic treatment, and reconstructive techniques, each relevant specifically to DSWI management. Collaborative efforts between cardiac and plastic surgeons, supported by ongoing research and innovation, are indispensable to advance sternal wound restoration and achieve superior outcomes in terms of patient welfare, morbidity and mortality reduction, and surgical efficacy.
C1 [Khashkhusha, Arwa] Univ Liverpool, Fac Hlth & Life Sci, Sch Med, Liverpool L3 5TR, England.
   [Butt, Sundas] Nottingham City Hosp, Dept Plast Surg, Nottingham NG5 1PB, England.
   [Abdelghaffar, Mariam] Royal Coll Surg Ireland, Sch Med, Bldg 2441,Rd 2835,Busaiteen 228,POB 15503, Muharraq, Bahrain.
   [Wang, William] Queen Mary Univ London, Barts & London Sch Med & Dent, London E1 2AD, England.
   [Rajananthanan, Asveny] Northampton Gen Hosp, Northampton NN1 5BD, England.
   [Roy, Sakshi] Queens Univ Belfast, Sch Pharm, Belfast BT9 7BL, North Ireland.
   [Khurshid, Bakht Noor] Univ Med & Dent Coll UMDC, Dept Med, Sargodha Rd,Univ Town, Faisalabad 38000, Punjab, Pakistan.
   [Zeinah, Mohamed] Ain Shams Univ, Fac Med, Cairo 11566, Egypt.
   [Harky, Amer] Liverpool Heart & Chest Hosp, Dept Cardiothorac Surg, Liverpool L14 3PE, England.
C3 University of Liverpool; Nottingham University Hospital NHS Trust;
   Nottingham City Hospital; Royal College of Surgeons in Ireland - RCSI;
   Royal College of Surgeons in Ireland - Medical University of Bahrain;
   University of London; Queen Mary University London; Queens University
   Belfast; Egyptian Knowledge Bank (EKB); Ain Shams University; Liverpool
   Heart & Chest Hospital
RP Harky, A (通讯作者)，Liverpool Heart & Chest Hosp, Dept Cardiothorac Surg, Liverpool L14 3PE, England.
EM asveny.rajananthanan2@nhs.net; amer.harky@lhch.nhs.uk
RI ; Butt, Sundas/LTZ-9164-2024; Harky, Amer/AAO-2125-2020
OI Roy, Sakshi/0000-0002-3519-9318; Butt, Sundas/0000-0003-0519-0715;
   khashkhusha, arwa/0000-0002-7407-8404; 
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NR 74
TC 6
Z9 8
U1 2
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD NOV
PY 2024
VL 11
IS 11
AR 361
DI 10.3390/jcdd11110361
PG 17
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA N6G3N
UT WOS:001365297000001
PM 39590204
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Caputo, GG
   Scarabosio, A
   Di Filippo, J
   Pagotto, A
   Tascini, C
   Berkane, Y
   Parodi, PC
AF Caputo, Glenda Giorgia
   Scarabosio, Anna
   Di Filippo, Jacopo
   Pagotto, Alberto
   Tascini, Carlo
   Berkane, Yanis
   Parodi, Pier Camillo
TI Redefining infection management in implant-based breast reconstruction:
   Insights and innovations from an 11-year retrospective analysis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Implant infection; Breast reconstruction; Breast infection; Infection
   diagnosis; Film Array; Molecular biology
ID METHICILLIN-RESISTANT; BIOFILM; PREVENTION; SEROMA
AB Background: Infections associated with implant-based breast reconstructive surgery are challenging for both patients and surgeons, often implying high recurrence rate, long treatments (both medical and surgical management), multiple invasive procedures, and delay of the end-result and, in some cases, even reconstruction failure. Early diagnosis is crucial but not always easy to achieve. Various treatment options are available and have been described in literature, with no clear winning strategy. Recent improvements in microbiological and therapeutic tools have led the authors to question what would be considered the best plan for reconstruction salvage approach. Methods: All patients who underwent implant-based breast reconstruction between 2012 and 2023 were enrolled. Clinical records regarding infections and treatment were retrospectively analyzed. Results: Among a total of 506 patients, 26 (5.14%) developed implant-associated infections. Discussing the results, we realized that previous protocol was old-fashioned and required improvements. Through a multidisciplinary approach, a new prevention and treatment algorithm was derived. First, microbiological screening through nasal and rectal swab allows for proper decontamination prior to intervention. However, the keystone improvement consists in the use of molecular biology analysis, thus minimizing diagnosis timing and allowing targeted antibiotic therapy shortly after the removal of the infected implant. In addition, a fundamental role is played using instillation negative pressure wound therapy as a temporary spacer to ensure the maintenance of the periprosthetic pocket. Conclusions: By following these precise steps in case of implant-associated infection, treatment can be optimized to reduce both therapy and hospitalization time, allowing the patient to achieve a reconstruction in a relatively short period. Level of evidence: IV (c) 2024 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Caputo, Glenda Giorgia; Scarabosio, Anna; Di Filippo, Jacopo; Parodi, Pier Camillo] Univ Udine, Dept Med Area DMED, Plast Surg Div, I-33100 Udine, Italy.
   [Caputo, Glenda Giorgia; Scarabosio, Anna; Di Filippo, Jacopo; Pagotto, Alberto; Tascini, Carlo; Parodi, Pier Camillo] Azienda Sanit Univ Friuli Cent ASUFC, I-33100 Udine, Italy.
   [Scarabosio, Anna] Massachusetts Gen Hosp, Div Plast & Reconstruct Surg, Boston, MA 02114 USA.
   [Scarabosio, Anna; Berkane, Yanis] Harvard Med Sch, Boston, MA 02114 USA.
   [Pagotto, Alberto; Tascini, Carlo] Univ Udine, Dept Med DMED, Infect Dis Div, I-33100 Udine, Italy.
   [Berkane, Yanis] Rennes Univ Hosp Ctr, Dept Plast Reconstruct & Aesthet Surg, Rennes, France.
   [Berkane, Yanis] Rennes Univ, INSERM, UMR1236, SITI Lab, Rennes, France.
   [Berkane, Yanis] Massachusetts Gen Hosp, Dept Surg, Vascularized Composite Allotransplantat Lab, Boston, MA 02114 USA.
C3 University of Udine; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   Medical School; University of Udine; CHU Rennes; Universite de Rennes;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Rennes; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Scarabosio, A (通讯作者)，Univ Udine, Dept Med Area DMED, Plast Surg Div, I-33100 Udine, Italy.; Scarabosio, A (通讯作者)，Azienda Sanit Univ Friuli Cent ASUFC, I-33100 Udine, Italy.
EM scarabosioanna@gmail.com
RI Parodi, Pier/AAG-8676-2019; Tascini, Carlo/L-5942-2017; Caputo,
   Glenda/AAT-6653-2020; Berkane, Yanis/ADJ-3663-2022; Scarabosio,
   Anna/HDO-1595-2022
OI Pagotto, Alberto/0000-0002-0772-1869; Di Filippo,
   Jacopo/0000-0002-3017-7152; Berkane, Yanis/0000-0003-4190-5132;
   Scarabosio, Anna/0000-0003-2993-8580
CR [Anonymous], Protocol for the Prevention and Management of Complications Related to ADM Implant-Based Breast Reconstructions Prevention Und Komplikationsmanagement Beim Einsatz Acellulerer Gewebematrix (ADM) Bei Der Implantatbasierten Brustrekonstruktion
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   Bhardwaj S, 2022, CURR PHARM DESIGN, V28, P2312, DOI 10.2174/1381612828666220608120238
   Caputo G, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59071231
   Cazzato V, 2023, PRS-GLOB OPEN, V11, DOI 10.1097/GOX.0000000000005145
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   del Pozo JL, 2015, ADV EXP MED BIOL, V831, P53, DOI 10.1007/978-3-319-09782-4_5
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   Gardner AP, 2023, PRS-GLOB OPEN, V11, DOI 10.1097/GOX.0000000000005062
   Graziano FD, 2023, CLIN PLAST SURG, V52, P235, DOI 10.1016/j.cps.2022.09.004
   Highton L, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001488
   Janis JE, 2016, PLAST RECONSTR SURG, V138, P240, DOI 10.1097/PRS.0000000000002245
   Jordan SW, 2016, PLAST RECONSTR SURG, V137, P1104, DOI 10.1097/01.prs.0000481102.24444.72
   Kaneko H, 2021, J GLOB ANTIMICROB RE, V24, P63, DOI 10.1016/j.jgar.2020.11.026
   Knackstedt R, 2021, J PLAST RECONSTR AES, V74, P425, DOI 10.1016/j.bjps.2020.08.058
   Lalani T, 2018, INFECT DIS CLIN N AM, V32, P877, DOI 10.1016/j.idc.2018.06.007
   Liu EH, 2022, PLAST SURG-CHIR PLAS, V30, P25, DOI 10.1177/2292550321995730
   Losito AR, 2022, ANTIBIOTICS-BASEL, V11, DOI 10.3390/antibiotics11050579
   McCarthy CM, 2008, PLAST RECONSTR SURG, V121, P1886, DOI 10.1097/PRS.0b013e31817151c4
   Mishra NN, 2022, ANTIMICROB AGENTS CH, V66, DOI 10.1128/AAC.01649-21
   Mortin LI, 2007, ANTIMICROB AGENTS CH, V51, P1787, DOI 10.1128/AAC.00738-06
   Myckatyn TM, 2023, PLAST RECONSTR SURG, V152, p919E, DOI 10.1097/PRS.0000000000010791
   Pardo J, 2016, DIAGN MICR INFEC DIS, V84, P159, DOI 10.1016/j.diagmicrobio.2015.10.023
   Phillips BT, 2016, PLAST RECONSTR SURG, V138, P751, DOI 10.1097/PRS.0000000000002530
   Pipitone G, 2023, ANTIBIOTICS-BASEL, V12, DOI 10.3390/antibiotics12121653
   Rezende-Pereira G, 2021, AESTHET SURG J, V41, P1144, DOI 10.1093/asj/sjaa416
   Sbitany H, 2018, SURG CLIN N AM, V98, P845, DOI 10.1016/j.suc.2018.03.011
   Sierra LAQ, 2022, TISSUE ENG REGEN MED, V19, P477, DOI 10.1007/s13770-021-00420-6
   Spear SL, 2010, PLAST RECONSTR SURG, V125, P1074, DOI 10.1097/PRS.0b013e3181d17fff
   Spear SL, 2009, AESTHET PLAST SURG, V33, P44, DOI 10.1007/s00266-008-9275-y
   Spear SL, 2004, PLAST RECONSTR SURG, V113, P1634, DOI 10.1097/01.PRS.0000117194.21748.02
   Suh LJ, 2022, J IMMUNOL RES, V2022, DOI 10.1155/2022/8536149
   Suich J, 2022, J MED MICROBIOL, V71, DOI 10.1099/jmm.0.001524
   Turner EJH, 2014, FUTURE ONCOL, V10, P1049, DOI 10.2217/fon.13.257
   Vorstenbosch J, 2023, PLAST RECONSTR SURG, V151, pE20, DOI 10.1097/PRS.0000000000009780
   Washer LL, 2012, INFECT DIS CLIN N AM, V26, P111, DOI 10.1016/j.idc.2011.09.003
   Wu PS, 2015, AESTHET PLAST SURG, V39, P227, DOI 10.1007/s00266-014-0444-x
   Xie JH, 2023, J PLAST SURG HAND SU, V57, P7, DOI 10.1080/2000656X.2021.1981351
   Zhang HL, 2015, BIOMED ENVIRON SCI, V28, P472, DOI 10.3967/bes2015.068
   Zhu LW, 2023, AESTHET PLAST SURG, V47, P1260, DOI 10.1007/s00266-023-03296-0
NR 43
TC 6
Z9 6
U1 1
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JAN
PY 2025
VL 100
BP 82
EP 92
DI 10.1016/j.bjps.2024.10.037
EA NOV 2024
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA O4J4W
UT WOS:001370810000001
PM 39608140
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ainslie-Garcia, MH
   Anderson, LA
   Bloch, BV
   Board, TN
   Chen, AF
   Craigie, S
   Danker, W 
   Gunja, N
   Harty, J
   Hernandez, VH
   Lebedeva, K
   Hameed, D
   Mont, MA
   Nunley, RM
   Parvizi, J
   Perka, C
   Piuzzi, NS
   Rolfson, O
   Rychlik, J
   Romanini, E
   Sanz-Ruiz, P
   Sierra, RJ
   Suleiman, L
   Tsiridis, E
   Vendittoli, PA
   Wangen, H
   Zagra, L
AF Ainslie-Garcia, Margaret H.
   Anderson, Lucas A.
   V. Bloch, Benjamin
   Board, Tim N.
   Chen, Antonia F.
   Craigie, Samantha
   Danker, Walter, III
   Gunja, Najmuddin
   Harty, James
   Hernandez, Victor H.
   Lebedeva, Kate
   Hameed, Daniel
   Mont, Michael A.
   Nunley, Ryan M.
   Parvizi, Javad
   Perka, Carsten
   Piuzzi, Nicolas S.
   Rolfson, Ola
   Rychlik, Joshua
   Romanini, Emilio
   Sanz-Ruiz, Pablo
   Sierra, Rafael J.
   Suleiman, Linda
   Tsiridis, Eleftherios
   Vendittoli, Pascal-Andre
   Wangen, Helge
   Zagra, Luigi
TI Identifying Critical Evidence Gaps in Wound Closure and Incision
   Management After Total Knee Arthroplasty: Delphi Panel Insights
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE wound management; total knee arthroplasty (TKA); evidence gaps; surgical
   wound closure; Delphi method; postoperative complications
ID PERIPROSTHETIC JOINT INFECTION; RISK CALCULATOR; TOTAL HIP; CONSENSUS;
   BURDEN
AB Background: Effective surgical wound management in total knee arthroplasty (TKA) is crucial for optimal healing and patient outcomes. Despite surgical advances, managing wounds to prevent complications remains challenging. This study aimed to identify and address evidence gaps in TKA wound management, including preoperative optimization, intraoperative options, and postoperative complication avoidance. Addressing these issues is vital for patient recovery and surgical success. a consensus on 26 statements about TKA wound management based on a comprehensive literature review. Additionally, the panel aimed to identify critical evidence gaps in wound management practices. Results: The panel achieved consensus on various wound management practices but highlighted significant evidence gaps. Consensus was reached on wound closure methods, including mesh-adhesive dressings, skin glue, staples, barbed sutures, and negative pressure wound therapy. However, further evidence is needed to address the cost-effectiveness of these methods and develop best practices for patient outcomes. Identifying these gaps highlights the need for more research to improve TKA wound care. Conclusions: Identifying major evidence gaps underscores the need for targeted research in TKA wound management. Addressing these gaps is crucial for developing effective, efficient, and patient-friendly wound care strategies. Future research should focus on comparative effectiveness studies and developing guidelines for emerging technologies. Bridging these gaps could improve patient outcomes, reduce complications, and enhance TKA surgery success. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Ainslie-Garcia, Margaret H.; Craigie, Samantha; Lebedeva, Kate; Rychlik, Joshua] EVERSANA, Dept Value & Evidence, Burlington, ON, Canada.
   [Anderson, Lucas A.] Univ Utah, Orthopaed Ctr, Salt Lake City, UT USA.
   [V. Bloch, Benjamin] Nottingham Univ Hosp NHS Trust, Nottingham Elect Orthopaed Serv, Hucknall Rd, Nottingham NG5 1PB, England.
   [Board, Tim N.] Wrightington Hosp, Ctr Hip Surg, Wigan, England.
   [Chen, Antonia F.] Harvard Med Sch, Brigham & WomenHospital, Dept Orthopaed Surg, Boston, MA USA.
   [Danker, Walter, III; Gunja, Najmuddin] J&J MedTech, Hlth Econ & Market Access, Raritan, NJ USA.
   [Harty, James] Cork Univ Hosp, Trauma & Orthopaed Dept, Cork, Ireland.
   [Hernandez, Victor H.] Univ Miami, Jackson Mem Hosp, Dept Orthopaed Surg & Rehabil, Miami, FL USA.
   [Hameed, Daniel; Mont, Michael A.] Sinai Hosp Baltimore, Rubin Inst Adv Orthoped, LifeBridge Hlth, Baltimore, MD USA.
   [Nunley, Ryan M.] Washington Univ, Dept Orthopaed Surg, St. Louis, MO USA.
   [Parvizi, Javad] Thomas Jefferson Univ, Rothman Inst, Philadelphia, PA USA.
   [Perka, Carsten] Orthopad Univ Klin Charite, Ctr Muskuloskeletale Chirurg, Berlin, Germany.
   [Piuzzi, Nicolas S.] Cleveland Clin Fdn, Dept Orthoped Surg, Cleveland, OH USA.
   [Rolfson, Ola] Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Orthopaed, Gothenburg, Sweden.
   [Romanini, Emilio] Polo Sanitario San Feliciano, Ctr Hip & Knee Arthroplasty, Rome, Italy.
   [Sanz-Ruiz, Pablo] Univ Complutense Madrid UCM, Fac Med, Dept Surg, Madrid, Spain.
   [Sierra, Rafael J.] Mayo Clin, Dept Orthoped Surg, Rochester, MN USA.
   [Suleiman, Linda] Rush Univ, Dept Orthopaed Surg, Med Ctr, Chicago, IL USA.
   [Tsiridis, Eleftherios] Univ Montreal, Maisonneuve Rosemont Hosp, Dept Surg, Montreal, PQ, Canada.
   [Vendittoli, Pascal-Andre] Aristotle Univ Thessaloniki, Gen Hosp Papageorgiou, Acad Orthoped Unit, Med Sch, Thessaloniki, Greece.
   [Wangen, Helge] Innlandet Hosp Trust, Dept Orthopaed Surg, Elverum, Norway.
   [Zagra, Luigi] IRCCS Ist Ortoped Galeazzi, Hip Dept, Milan, Italy.
C3 Utah System of Higher Education; University of Utah; Nottingham
   University Hospital NHS Trust; Harvard University; Harvard Medical
   School; University College Cork; University of Miami; Sinai Hospital of
   Baltimore; Washington University (WUSTL); Rothman Institute; Thomas
   Jefferson University; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Cleveland Clinic Foundation;
   University of Gothenburg; Complutense University of Madrid; Mayo Clinic;
   Rush University; Universite de Montreal; Aristotle University of
   Thessaloniki; Papageorgiou Hospital; Innlandet Hospital Trust; IRCCS
   Istituto Ortopedico Galeazzi
RP Mont, MA (通讯作者)，Sinai Hosp Baltimore, Rubin Inst Adv Orthoped, 2401 West Belvedere Ave, Baltimore, MD 21215 USA.
RI Zagra, Luigi/PFZ-1383-2026; Bloch, Benjamin/I-1041-2019; Perka,
   Carsten/ABG-6505-2021; Vendittoli, Pascal-Andre/J-9621-2013; Hernandez,
   Victor/AAG-4458-2020; /I-9296-2019; Danker III, Walter/AAP-5078-2020;
   Rolfson, Ola/AAT-2206-2020; sanz-ruiz, pablo/H-6539-2015
OI Danker III, Walter/0000-0002-9741-5821; sanz-ruiz,
   pablo/0000-0002-7588-1880
CR Ainslie-Garcia M, 2024, J ARTHROPLASTY, V39, P878, DOI 10.1016/j.arth.2023.12.032
   Beiderbeck D, 2021, METHODSX, V8, DOI 10.1016/j.mex.2021.101401
   Bozic KJ, 2013, CLIN ORTHOP RELAT R, V471, P574, DOI 10.1007/s11999-012-2605-z
   Bozic KJ, 2012, J BONE JOINT SURG AM, V94A, P794, DOI 10.2106/JBJS.K.00072
   Chen ZM, 2024, J KNEE SURG, V37, P238, DOI 10.1055/s-0043-1768248
   Chen ZM, 2022, J KNEE SURG, V35, P1524, DOI 10.1055/s-0042-1758674
   Chen Zhongming, 2022, SURGICAL TECHNOLOGY INTERNATIONAL-INTERNATIONAL DEVELOPMENTS IN SURGERY AND SURGICAL RESEARCH, V41
   Clarke MT, 2001, J BONE JOINT SURG BR, V83B, P40, DOI 10.1302/0301-620X.83B1.10795
   Diamond IR, 2014, J CLIN EPIDEMIOL, V67, P401, DOI 10.1016/j.jclinepi.2013.12.002
   Hasson F, 2000, J ADV NURS, V32, P1008, DOI 10.1046/j.1365-2648.2000.01567.x
   Henderson BA, 2023, CLIN OPHTHALMOL, V17, P2109, DOI 10.2147/OPTH.S412847
   Higuera-Rueda CA, 2021, J ARTHROPLASTY, V36, pS295, DOI 10.1016/j.arth.2021.02.076
   Kuhn K-D, 2017, Management of Periprosthetic Joint Infection: a global perspective on diagnosis, treatment options, prevention strategies and their economic impact
   Kurtz S, 2007, J BONE JOINT SURG AM, V89A, P780, DOI 10.2106/JBJS.F.00222
   Kurtz SM, 2012, J ARTHROPLASTY, V27, P61, DOI 10.1016/j.arth.2012.02.022
   Rothfusz CA, 2021, JBJS REV, V9, DOI 10.2106/JBJS.RVW.20.00301
   Ruiz-Tovar J, 2022, J AM COLL SURGEONS, V234, P1, DOI 10.1097/XCS.0000000000000022
   Siddiqi A, 2021, J BONE JOINT SURG AM, V103, P1335, DOI 10.2106/JBJS.20.01184
   Sodhi Nipun, 2022, SURGICAL TECHNOLOGY INTERNATIONAL-INTERNATIONAL DEVELOPMENTS IN SURGERY AND SURGICAL RESEARCH, V41
   Sundaram K, 2021, Musculoskelet Surg, V105, P275, DOI 10.1007/s12306-020-00654-y
   Sundaram K, 2020, EUR J ORTHOP SURG TR, V30, P447, DOI 10.1007/s00590-019-02591-4
   Tan TL, 2018, J BONE JOINT SURG AM, V100, P777, DOI 10.2106/JBJS.16.01435
   Tarazi JM, 2021, J KNEE SURG, V34, P1396, DOI 10.1055/s-0041-1735282
   Yoon BH, 2020, J ARTHROPLASTY, V35, P933, DOI 10.1016/j.arth.2019.11.029
   Zmistowski B, 2013, J BONE JOINT SURG AM, V95A, P1869, DOI 10.2106/JBJS.L.00679
NR 25
TC 2
Z9 3
U1 0
U2 7
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD JAN
PY 2025
VL 40
IS 1
DI 10.1016/j.arth.2024.06.057
EA NOV 2024
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA O5S8L
UT WOS:001371729300001
PM 38972434
DA 2026-07-24
ER
PT J
AU Sanna, A
   Targa, S
   Mantovan, B
   De Luca, M
AF Sanna, Andrea
   Targa, Simone
   Mantovan, Barbara
   De Luca, Maurizio
TI The Enhanced-View Totally Extraperitoneal Repair for Ventral and
   Incisional Hernia: Midterm Results of an Evolving Technique
SO JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
LA English
DT Article
DE hernia; eTEP; ventral and incisional hernia; minimally invasive
   technique
ID COMPLICATIONS; METAANALYSIS; MESH
AB Introduction: In the field of abdominal wall hernias, several innovative procedures have been developed, including the extended/enhanced-view totally extraperitoneal (eTEP) hernia repair technique. Initially introduced for laparoscopic hernia repair by J. Daes, it was subsequently applied to ventral hernia repair (VHR) and incisional hernia repair (IVHR) by I. Belyansky et al. This article presents the midterm experience and outcomes of our center's experience with the endoscopic technique based on the principles of eTEP during IVHR and VHR.Method: A review was conducted of a prospectively collected database of abdominal wall hernia. Patients who underwent eTEP VHR or IVHR between October 2018 and February 2021 were identified.Results: A total of 51 patients underwent an eTEP-RS or eTEP-TAR procedure, with a 24-month follow-up period. Of the 51 patients included in the study, 43 underwent eTEP-RS treatment, while 8 required an additional transversus abdominis release (3 unilaterally). One patient developed a large hematoma necessitating reoperation and drainage via the eTEP approach. Seven patients developed seromas, which were treated conservatively, while 2 patients experienced surgical site infections, which were managed with a single-use negative pressure wound therapy system. Two patients exhibited recurrence at sites above the epigastric edge of the mesh.Conclusion: Moreover, the advancement of minimally invasive surgical techniques for abdominal wall reconstruction has rendered the eTEP approach a viable option for both primary and incisional VHR, with promising midterm outcomes.
C1 [Sanna, Andrea; Targa, Simone; Mantovan, Barbara; De Luca, Maurizio] Aulss 5 Polesana, Dept Gen Surg, Viale Tre Martiri 89, I-45100 Rovigo, Italy.
C3 ULSS 5 Polesana
RP Sanna, A (通讯作者)，Aulss 5 Polesana, Dept Gen Surg, Viale Tre Martiri 89, I-45100 Rovigo, Italy.
EM and_sanna@yahoo.it
RI sanna, andrea/IWE-3206-2023
OI sanna, andrea/0000-0002-5615-6915
CR Al Chalabi H, 2015, INT J SURG, V20, P65, DOI 10.1016/j.ijsu.2015.05.050
   Belyansky I, 2018, SURG ENDOSC, V32, P1525, DOI 10.1007/s00464-017-5840-2
   Binnebösel M, 2010, HERNIA, V14, P71, DOI 10.1007/s10029-009-0580-4
   Bittner JG, 2018, The Art of hernia surgery, P115
   Carbonel A., 2016, HERNIA SURG CURRENT
   Daes J, 2021, J AM COLL SURGEONS, V233, pE1, DOI 10.1016/j.jamcollsurg.2021.05.007
   Daes J, 2012, SURG ENDOSC, V26, P1187, DOI 10.1007/s00464-011-1993-6
   Eriksen J R, 2007, Hernia, V11, P481, DOI 10.1007/s10029-007-0282-8
   Forbes SS, 2009, BRIT J SURG, V96, P851, DOI 10.1002/bjs.6668
   Jani K, 2019, J MINIM ACCESS SURG, V15, P362, DOI 10.4103/0972-9941.188630
   Jani K, 2019, J MINIM ACCESS SURG, V15, P287, DOI 10.4103/jmas.JMAS_20_19
   Jenkins ED, 2010, SURG ENDOSC, V24, P3002, DOI 10.1007/s00464-010-1076-0
   Kokotovic D, 2016, JAMA-J AM MED ASSOC, V316, P1575, DOI 10.1001/jama.2016.15217
   Kumar N, 2021, SURG ENDOSC, V35, P5072, DOI 10.1007/s00464-020-07990-x
   LEBLANC KA, 1993, SURG LAPAROSC ENDOSC, V3, P39
   Miserez M, 2002, SURG ENDOSC, V16, P1207, DOI 10.1007/s00464-001-9198-z
   Muysoms F, 2018, HERNIA, V22, P743, DOI 10.1007/s10029-018-1804-2
   Parker S, 2018, SPRINGER EBOOKS, P103, DOI [10.1007/978-3-319-72626-7_10, DOI 10.1007/978-3-319-72626-7_10, 10.1007/978-3-319-72626-710]
   Penchev D, 2019, SURG ENDOSC, V33, P3749, DOI 10.1007/s00464-019-06669-2
   Qandeel H, 2016, SURG ENDOSC, V30, P1480, DOI 10.1007/s00464-015-4356-x
   Quezada N, 2022, SURG ENDOSC, V36, P632, DOI 10.1007/s00464-021-08330-3
   Ramana B, 2021, HERNIA, V25, P545, DOI 10.1007/s10029-020-02216-4
   Sanna A, 2020, J LAPAROENDOSC ADV S, V30, P246, DOI 10.1089/lap.2019.0661
   Suwa K, 2016, SURG TODAY, V46, P764, DOI 10.1007/s00595-015-1219-y
   Tasdelen HA, 2023, SURG ENDOSC, V37, P3260, DOI 10.1007/s00464-023-09922-x
   Tasdelen HA, 2022, SURG ENDOSC, V36, P4614, DOI 10.1007/s00464-021-08995-w
   Zhang YY, 2014, WORLD J SURG, V38, P2233, DOI 10.1007/s00268-014-2578-z
NR 27
TC 0
Z9 1
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1092-6429
EI 1557-9034
J9 J LAPAROENDOSC ADV S
JI J. Laparoendosc. Adv. Surg. Tech.
PD JAN 1
PY 2025
VL 35
IS 1
BP 48
EP 54
DI 10.1089/lap.2023.0354
EA DEC 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA S5Y9I
UT WOS:001372196000001
PM 39648768
DA 2026-07-24
ER
PT J
AU Wang, JHY
   Williams, B
   Wlodarczyk, JR
   Gupta, A
   Kim, D
   Cologne, KG
   Koller, SE
   Hsieh, CSE
   Duldulao, MP
   Shin, J
AF Wang, Johnny
   Williams, Brian
   Wlodarczyk, Jordan R.
   Gupta, Abhinav
   Kim, Debora
   Cologne, Kyle G.
   Koller, Sarah E.
   Hsieh, Christine
   Duldulao, Marjun P.
   Shin, Joongho
TI First Experience with the NPseal®: A Novel Mechanically Powered Negative
   Pressure Dressing Applied to Colorectal Surgery Wounds
SO SURGICAL INNOVATION
LA English
DT Article
DE negative pressure wound therapy; closed-incisional negative pressure
   wound therapy; surgical site infection; wound healing; colorectal
ID SURGICAL SITE INFECTIONS; CARE-ASSOCIATED INFECTIONS; VACUUM-ASSISTED
   CLOSURE; FINANCIAL IMPACT; THERAPY; COST; RISK; PREVENTION; MANAGEMENT;
   TRIAL
AB Background The use of prophylactic closed-incisional negative pressure wound therapy after colorectal procedures has been shown to reduce postoperative wound complications and surgical site infection. We present our experience with a novel, closed-incision, mechanically powered negative pressure (MP-NPD) dressing after colorectal procedures.Methods This was a prospective, single-center, single-arm observational study assessing patient reported and wound healing outcomes of colorectal surgical incisions dressed with a MP-NPD. Consecutive patients, 18 years and older, that met inclusion criteria were enrolled between May 2021 and December 2021.Results Thirty patients were included (13 male/17 female) with a mean age of 62.7 +/- 11.8 years and mean body mass index of 25.5 +/- 4.4 kg/m2. The mean incision length covered was 3.0 +/- 1.8 cm. The median number of manual pinches required to initially activate the dressing with negative pressure within -75 to -125 mmHg was 12 (range 7-20). Four dressings were changed (13.3%) after drainage was noted inside the pump; not including these, 88.5% (23/26) of dressings held pressure consistently without any re-pinching during the 72-h period since they were first applied in the operating room. 75.9% of patients reported the dressing was "very comfortable" and none reported the dressing restricted mobility. 79.3% of patients reported the dressing was "very easy" to use. There were no cases of major wound complication or surgical site infection within 30 days.Conclusion The use of MP-NPD appears to be feasible on primarily-closed colorectal incisions. Further randomized controlled study is warranted to ascertain its clinical efficacy.
C1 [Wang, Johnny; Williams, Brian; Wlodarczyk, Jordan R.; Gupta, Abhinav; Cologne, Kyle G.; Koller, Sarah E.; Hsieh, Christine; Duldulao, Marjun P.; Shin, Joongho] USC, Keck Hosp, Div Colorectal Surg, 1441 Eastlake Ave, Suite 7418, Los Angeles, CA 90033 USA.
   [Wang, Johnny; Williams, Brian; Wlodarczyk, Jordan R.; Gupta, Abhinav; Kim, Debora; Cologne, Kyle G.; Koller, Sarah E.; Hsieh, Christine; Duldulao, Marjun P.; Shin, Joongho] USC, Keck Sch Med, Los Angeles, CA USA.
C3 University of Southern California; University of Southern California
   Keck Hospital; University of Southern California; University of Southern
   California Keck Hospital
RP Williams, B (通讯作者)，USC, Keck Hosp, Div Colorectal Surg, 1441 Eastlake Ave, Suite 7418, Los Angeles, CA 90033 USA.
EM Brian.Williams@med.usc.edu
OI Willia, Brian/0000-0003-3222-3818
CR Anderson DJ, 2014, INFECT CONT HOSP EP, V35, P605, DOI 10.1086/676022
   Bonds AM, 2013, DIS COLON RECTUM, V56, P1403, DOI 10.1097/DCR.0b013e3182a39959
   Cagney D, 2020, WORLD J SURG, V44, P1526, DOI 10.1007/s00268-019-05335-x
   Cantero R, 2016, ADV SKIN WOUND CARE, V29, P114, DOI 10.1097/01.ASW.0000480458.60005.34
   Carrano FM, 2021, BJS OPEN, V5, DOI 10.1093/bjsopen/zrab116
   Chadi SA, 2014, DIS COLON RECTUM, V57, P999, DOI 10.1097/DCR.0000000000000161
   Gantz O, 2019, AM SURGEON, V85, P142
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   Heard C, 2017, J TISSUE VIABILITY, V26, P79, DOI 10.1016/j.jtv.2016.06.001
   Howell RD, 2011, CURR ORTHOP PRACT, V22, P176, DOI 10.1097/BCO.0b013e31820b3e21
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Hübner M, 2011, ARCH SURG-CHICAGO, V146, P1240, DOI 10.1001/archsurg.2011.176
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   Lahat G, 2005, Tech Coloproctol, V9, P206, DOI 10.1007/s10151-005-0228-z
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   Wierdak M, 2021, TECH COLOPROCTOL, V25, P185, DOI 10.1007/s10151-020-02372-w
   Yoon SI, 2015, ANN COLOPROCTOL, V31, P29, DOI 10.3393/ac.2015.31.1.29
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NR 31
TC 1
Z9 2
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD APR
PY 2025
VL 32
IS 2
BP 127
EP 140
DI 10.1177/15533506241307729
EA DEC 2024
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 0AM3B
UT WOS:001373253100001
PM 39653591
DA 2026-07-24
ER
PT J
AU De Luca, GM
   Tedeschi, P
   Maruccia, M
   Malerba, S
   Puglisi, GR
   Prete, FP
   Vittore, F
   Giudice, G
   Testini, M
AF De Luca, Giuseppe Massimiliano
   Tedeschi, Pasquale
   Maruccia, Michele
   Malerba, Silvia
   Puglisi, Giuliana Rachele
   Prete, Francesco Paolo
   Vittore, Francesco
   Giudice, Giuseppe
   Testini, Mario
TI Use of Negative Pressure Wound Therapy in the Management of Extreme
   Crush Abdominopelvic Injuries: An In-Depth Case Study and Literature
   Review
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE abdominopelvic injury; crush injuries; multidisciplinary approach;
   negative pressure wound therapy; wound care
ID VACUUM-ASSISTED CLOSURE; BACTERIAL LOAD; EXPERIENCE; EFFICACY
AB Background. Negative pressure wound therapy (NPWT) has significantly transformed wound care, particularly the management of complex injuries and unresponsive wounds. Crush injuries from road traffic accidents pose intricate challenges due to their severity, often requiring multimodal interventions. NPWT accelerates healing by stimulating tissue formation and reducing inflammation; however, its use necessitates careful patient selection and wound assessment for potential complications. Case Report. A 16-year-old male sustained catastrophic crush injuries involving extensive soft tissue damage, bone exposure, bowel perforation, and genitourinary trauma in a vehicular accident involving a farm vehicle run-over event. The patient received various interventions, including NPWT combined with tension sutures for wound management. The case highlights the multidisciplinary approach required to manage primary wounds and complications. NPWT facilitated granulation tissue formation, aiding wound closure without necessitating alternative methods such as skin grafting or flap coverage. Conclusion. This case underscores NPWT's effectiveness in the management of severe crush injuries. While successful wound closure was achieved, as of this writing postoperative-recovery challenges persist, emphasizing the importance of multidisciplinary care in long-term recovery. The case reaffirms NPWT as a valuable option in managing extensive injuries resulting from road traffic accidents.
C1 [De Luca, Giuseppe Massimiliano; Maruccia, Michele; Malerba, Silvia; Puglisi, Giuliana Rachele; Prete, Francesco Paolo; Vittore, Francesco] Univ Bari Aldo Moro, Dept Precis & Regenerat Med, UOC Gen Surg, Univ V Bonomo, I-70121 Bari, Italy.
   [De Luca, Giuseppe Massimiliano; Maruccia, Michele; Malerba, Silvia; Puglisi, Giuliana Rachele; Prete, Francesco Paolo; Vittore, Francesco] Univ Bari Aldo Moro, Jonica Area Dimepre J, UOC Gen Surg, Univ V Bonomo, Bari, Italy.
   [Tedeschi, Pasquale; Giudice, Giuseppe; Testini, Mario] Univ Bari Aldo Moro, Dept Precis & Regenerat Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
   [Tedeschi, Pasquale; Giudice, Giuseppe; Testini, Mario] Univ Bari Aldo Moro, Div Plast & Reconstruct Surg, Ionian Area, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro; Universita degli
   Studi di Bari Aldo Moro
RP Tedeschi, P (通讯作者)，Univ Bari Aldo Moro, Dept Precis & Regenerat Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy.; Tedeschi, P (通讯作者)，Univ Bari Aldo Moro, Div Plast & Reconstruct Surg, Ionian Area, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM Pasquale.tedeschi93@gmail.com
RI Prete, Francesco/J-7141-2019; Maruccia, Michele/ABE-9839-2020
OI Malerba, Silvia/0000-0002-6462-2090
CR Agarwal A, 2022, J ORTHOP TRAUMA, V36, pS1, DOI 10.1097/BOT.0000000000002431
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   [Anonymous], 44. World Health Organization. 2024. https://www.who.int/news-room/fact-sheets/detail/ecoli
   [Anonymous], 2021, Breast cancer: World Health Organization Internet
   [Anonymous], 2019, Cardiovascular diseases
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   Zaver V., 2024, StatPearls
NR 39
TC 0
Z9 1
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2024
VL 36
IS 10
BP 350
EP 356
DI 10.25270/wnds/24001
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA O8Y2B
UT WOS:001373907700005
PM 39500714
DA 2026-07-24
ER
PT J
AU Holbert, MD
   Wood, F
   Holland, AJA
   Teague, W
   Kimble, RM
   Crellin, D
   Frear, CC
   Storey, K
   Phillips, N
   Singer, Y
   Dimanopoulos, TA
   Martin, L
   Cuttle, L
   Vagenas, D
   Mcphail, SM
   Calleja, P
   Duff, J
   De Young, A
   Griffin, BR
AF Holbert, Maleea D.
   Wood, Fiona
   Holland, Andrew J. A.
   Teague, Warwick
   Kimble, Roy M.
   Crellin, Dianne
   Frear, Cody C.
   Storey, Kristen
   Phillips, Natalie
   Singer, Yvonne
   Dimanopoulos, Tanesha A.
   Martin, Lisa
   Cuttle, Leila
   Vagenas, Dimitrios
   Mcphail, Steven M.
   Calleja, Pauline
   Duff, Jed
   De Young, Alexandra
   Griffin, Bronwyn R.
TI Implementation of negative pressure for acute pediatric burns (INPREP):
   A stepped-wedge cluster randomized controlled trial protocol
SO PLOS ONE
LA English
DT Article
ID WOUND THERAPY; SUBATMOSPHERIC PRESSURE; OPTIMAL DURATION; HEALING TIME;
   PROGRESSION; MANAGEMENT; DRESSINGS; CORTISOL; SCARS
AB Background Acute application of adjunctive negative pressure wound therapy (NPWT) significantly improves time to re-epithelialization in pediatric burn patients. This adjunctive treatment has not yet been broadly or routinely adopted as a standard primary burns dressing strategy. The Implementation of Negative PRessurE for acute Pediatric burns (INPREP) trial will implement and evaluate the impact of adjunctive NPWT in parallel with co-designed implementation strategies and resources across four major pediatric hospitals.Methods We will conduct a multi-center, prospective, stepped-wedge cluster randomized controlled trial to implement adjunctive NPWT for acute pediatric burns. Participants will include pediatric burn patients presenting to one of four Australian tertiary pediatric hospitals for burn treatment. The intervention is adjunctive NPWT in parallel with co-designed and tailored implementation strategies and a suite of NPWT implementation resources, which form the INPREP toolkit. Using a hybrid type III design, this trial aims to evaluate the effectiveness of NPWT implementation in parallel with the INPREP toolkit using (i) implementation outcomes (e.g., adoption, appropriateness, acceptability, feasibility, and sustainability) and (ii) clinical outcomes (e.g., days to re-epithelialization, scar management requirements, skin grafting requirements). The primary outcome of this trial is treatment adoption-the proportion of eligible patients who receive NPWT.Discussion This manuscript outlines a protocol for a hybrid type III stepped-wedge cluster randomized controlled trial of adjunctive NPWT implementation in acute pediatric burn care. We anticipate that NPWT implementation in parallel with the INPREP toolkit will be generalizable to emergency departments and burn services across Australia, and evidence generated will inform pediatric burn care internationally.Trial registration Australian and New Zealand Clinical Trials Registry: ACTRN12622000166774. Registered 1 February 2022.
C1 [Holbert, Maleea D.; Storey, Kristen; Singer, Yvonne; Dimanopoulos, Tanesha A.; Griffin, Bronwyn R.] Griffith Univ, Sch Nursing & Midwifery, Nathan Campus, South Brisbane, Qld, Australia.
   [Holbert, Maleea D.; Kimble, Roy M.; Frear, Cody C.; Storey, Kristen; Phillips, Natalie; Dimanopoulos, Tanesha A.; De Young, Alexandra; Griffin, Bronwyn R.] Childrens Hlth Queensland Hosp & Hlth Serv, South Brisbane, Qld, Australia.
   [Wood, Fiona; Martin, Lisa] Perth Childrens Hosp, Nedlands, WA, Australia.
   [Wood, Fiona; Martin, Lisa] Univ Western Australia, Burn Injury Res Unit, Crawley, WA, Australia.
   [Holland, Andrew J. A.] Childrens Hosp Westmead, Burns Unit, Westmead, NSW, Australia.
   [Holland, Andrew J. A.] Univ Sydney, Fac Med & Hlth, Sydney Med Sch, Sydney, NSW, Australia.
   [Teague, Warwick] Murdoch Childrens Res Inst, Surg Res, Parkville, Vic, Australia.
   [Teague, Warwick; Crellin, Dianne] Royal Childrens Hosp Melbourne, Clin Psychol Serv, Parkville, Vic, Australia.
   [Teague, Warwick; Crellin, Dianne] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia.
   [Teague, Warwick] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Kimble, Roy M.; Frear, Cody C.] Univ Queensland, Fac Med, Brisbane, Qld, Australia.
   [Crellin, Dianne] Univ Melbourne, Dept Nursing, Parkville, Vic, Australia.
   [Phillips, Natalie] Univ Queensland, Child Hlth Res Ctr, South Brisbane, Qld, Australia.
   [Cuttle, Leila] Queensland Univ Technol, Fac Hlth, Sch Biomed Sci, Brisbane, Australia.
   [Vagenas, Dimitrios] Queensland Univ Technol, Fac Hlth, Sch Publ Hlth & Social Work, Brisbane, Australia.
   [Mcphail, Steven M.] Queensland Univ Technol, Australian Ctr Hlth Serv Innovat, Sch Publ Hlth & Social Work, Ctr Healthcare Transformat,Fac Hlth, Brisbane, Kelvin Grove, Australia.
   [Mcphail, Steven M.] Queensland Univ Technol, Ctr Healthcare Transformat, Sch Publ Hlth & Social Work, Brisbane, Kelvin Grove, Australia.
   [Calleja, Pauline] James Cook Univ, Coll Healthcare Sci, Cairns, Australia.
   [Duff, Jed] Queensland Univ Technol, Fac Hlth, Ctr Healthcare Transformat, Brisbane, Australia.
C3 Griffith University; Childrens Health Queensland Hospital & Health
   Service; Perth Childrens Hospital; University of Western Australia; NSW
   Health; Sydney Childrens Hospitals Network; The Children's Hospital at
   Westmead; University of Sydney; University of Sydney; Murdoch Children's
   Research Institute; Royal Children's Hospital Melbourne; University of
   Melbourne; Monash University; University of Queensland; University of
   Melbourne; University of Queensland; Queensland University of Technology
   (QUT); Queensland University of Technology (QUT); Queensland University
   of Technology (QUT); Queensland University of Technology (QUT); James
   Cook University; Queensland University of Technology (QUT)
RP Holbert, MD (通讯作者)，Griffith Univ, Sch Nursing & Midwifery, Nathan Campus, South Brisbane, Qld, Australia.; Holbert, MD (通讯作者)，Childrens Hlth Queensland Hosp & Hlth Serv, South Brisbane, Qld, Australia.
EM m.holbert@griffith.edu.au
RI De Young, Alex/D-9093-2019; McPhail, Steven/JMR-2141-2023; Phillips,
   Natalie/LBI-7045-2024; Griffin, Bronwyn/AEB-6299-2022; Teague,
   Warwick/AAY-7260-2020; Calleja, Pauline/AAE-7981-2020; Holland,
   Andrew/N-5547-2017; Singer, Yvonne/LEN-2822-2024; Cuttle,
   Leila/C-5223-2008; Kimble, Roy/B-4160-2011; fiona, wood/F-4703-2013;
   Duff, Jed/AAV-9927-2020
OI Martin, Lisa Joanne/0000-0001-8947-834X; McPhail,
   Steven/0000-0002-1463-662X; Holbert, Maleea/0000-0002-9902-5122;
   Griffin, Bronwyn/0000-0002-6182-9125; Teague,
   Warwick/0000-0003-4747-6025; Calleja, Pauline/0000-0001-5674-1404;
   Holland, Andrew/0000-0003-3745-8704; Singer, Yvonne/0000-0001-6225-5891;
   fiona, wood/0000-0001-5427-6588; Duff, Jed/0000-0003-1427-0303
FU National Health and Medical Research Council Partnership Projects
   [2006970]; National Health and Medical Research Council (NHMRC)
   [2006970] Funding Source: National Health and Medical Research Council
   (NHMRC)
FX National Health and Medical Research Council Partnership Projects [PRC2
   Funding ID: 2006970] The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 69
TC 1
Z9 1
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 10
PY 2024
VL 19
IS 12
AR e0315278
DI 10.1371/journal.pone.0315278
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA P1F0N
UT WOS:001375443900018
PM 39656723
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Papadakos, SP
   Argyrou, A
   Katsaros, I
   Lekakis, V
   Mpouga, G
   Vergadis, C
   Fytili, P
   Koutsoumpas, A
   Schizas, D
AF Papadakos, Stavros P.
   Argyrou, Alexandra
   Katsaros, Ioannis
   Lekakis, Vasileios
   Mpouga, Georgia
   Vergadis, Chrysovalantis
   Fytili, Paraskevi
   Koutsoumpas, Andreas
   Schizas, Dimitrios
TI The Impact of EndoVAC in Addressing Post-Esophagectomy Anastomotic Leak
   in Esophageal Cancer Management
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE EndoVAC; negative pressure wound therapies; NPWT; esophageal cancer;
   endoscopic therapy; esophagectomy; anastomotic leakage
ID ENDOSCOPIC VACUUM THERAPY; CHEMORADIOTHERAPY PLUS SURGERY; UPPER GI
   LEAKS; ASSISTED CLOSURE; NEOADJUVANT CHEMORADIOTHERAPY; SPONGE SOS;
   STENT; COMPLICATIONS; PRESSURE; EPIDEMIOLOGY
AB Anastomotic leakage (AL) remains a major complication after esophagectomy, especially in patients with esophagogastric cancers who have undergone neoadjuvant therapies, which can impair tissue healing. Endoscopic vacuum-assisted closure (EndoVAC) is an innovative approach aimed at managing AL by facilitating wound drainage, reducing infection, and promoting granulation tissue formation, thus supporting effective healing. This review explores the role and effectiveness of EndoVAC in treating AL post-esophagectomy in esophageal cancer patients. We present an overview of its physiological principles, including wound contraction, enhanced tissue perfusion, and optimized microenvironment, which collectively accelerate wound closure. In addition, we examine clinical outcomes from recent studies, which indicate that EndoVAC is associated with improved leak resolution rates and potentially shorter hospital stays compared to traditional methods. Overall, this review highlights EndoVAC as a promising tool for AL management and underscores the need for continued investigation to refine its protocols and broaden its accessibility. By optimizing EndoVACs use, multidisciplinary teams can improve patient outcomes and advance esophageal cancer care.
C1 [Papadakos, Stavros P.; Argyrou, Alexandra; Lekakis, Vasileios; Mpouga, Georgia; Fytili, Paraskevi; Koutsoumpas, Andreas] Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Gastroenterol, Athens 11527, Greece.
   [Katsaros, Ioannis; Schizas, Dimitrios] Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Surg 1, Athens 11527, Greece.
   [Vergadis, Chrysovalantis] Laikon Gen Hosp, Dept Radiol, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; Laiko General Hospital;
   Laiko General Hospital; National & Kapodistrian University of Athens;
   Laiko General Hospital
RP Katsaros, I; Schizas, D (通讯作者)，Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Surg 1, Athens 11527, Greece.
EM stavrospapadakos@gmail.com; argyalex89@gmail.com; ioankats@med.uoa.gr;
   lekakis.vas@gmail.com; gioulibouga@gmail.com; valvergadis@yahoo.gr;
   info@drfytili.gr; andreas.koutsoumpas@laiko.gr; schizasad@gmail.com
RI Schizas, Dimitrios/Z-3323-2019; Katsaros, Ioannis/AHI-2537-2022;
   Papadakos, Stavros/AFF-9357-2022
OI Schizas, Dimitrios/0000-0002-7046-0112; Argyrou,
   Alexana/0000-0002-1569-5592; Katsaros, Ioannis/0000-0002-6743-8942;
   Papadakos, Stavros/0000-0003-1583-1125
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NR 100
TC 6
Z9 7
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2024
VL 13
IS 23
AR 7113
DI 10.3390/jcm13237113
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA P2U1B
UT WOS:001376514000001
PM 39685572
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Milcheski, DA
   Clivatti, GM
   Santos, RA Jr
   González, CVS
   Monteiro, AA Jr
   Gemperli, R
AF Milcheski, Dimas A.
   Clivatti, Gustavo M.
   Santos Junior, Rafael A.
   Gonzalez, Carol V. S.
   Monteiro Jr, Araldo A.
   Gemperli, Rolf
TI Effectiveness of negative-pressure wound therapy with instillation
   compared to standard negative-pressure wound therapy and traditional
   gauze layer dressing for the treatment of acute traumatic wounds: A
   randomized controlled trial
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Wounds and injuries; Negative-pressure wound therapy; Dressings; Trauma;
   Lower limb; Plastic surgery
ID OUTCOMES
AB Background: Acute traumatic wounds often require prolonged healing time and hospitalization. Negative-pressure wound therapy with instillation and dwell time (NPWTi-d) has demonstrated effectiveness in accelerating patient healing over traditional NPWT, and its benefits are well established in the treatment of chronic infected wounds. However, randomized studies examining the use of NPWTi-d in acute traumatic wounds are scarce. This study aimed to examine the effectiveness of NPWTi-d compared to traditional gauze layer dressing Methods: This single-center, randomized, pragmatic, controlled clinical trial included 120 adult patients with acute traumatic wounds from traffic accidents randomized to NPWTi-d (n = 39), NPWT (n = 41), and gauze dressing (n = 40). Following surgical debridement of the wound bed, all patients underwent definitive wound closure with delayed primary closure, skin grafting, or surgical flaps. The primary outcomes were wound closure time, number of surgical procedures, and hospital length of stay. The secondary outcomes were primary closure type, amputations, complications, and death. Results: Wound closure time was significantly lower in patients with NPWTi-d compared to patients with NPWT and gauze dressing (6.1 vs. 10 vs. 11.7 days, respectively; p < 0.001). Patients with NPWTi-d had fewer surgical procedures than patients with NPWT and gauze dressing (3.0 vs. 3.5 vs. 6.2, respectively; p < 0.001). No significant differences in length of stay were observed among the groups. Conclusions: In this study, patients with acute traumatic wounds who received NPWTi-d experienced shorter wound closure time and fewer surgical procedures than patients who received NPWT or gauze dressing. Clinical Trial Registration: The current study is registered on the Brazilian Clinical Trials Registry (ReBec) platform under the name Comparison between Traditional Dressing, V.A.C. Dressing and V.A.C. Dressing with Instillation in Complex Wounds, ID n degrees RBR-658g535 at https:// (c) 2024 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Milcheski, Dimas A.; Clivatti, Gustavo M.; Santos Junior, Rafael A.; Monteiro Jr, Araldo A.; Gemperli, Rolf] Univ Sao Paulo, Fac Med, Div Plast Surg, Sao Paulo, Brazil.
   [Gonzalez, Carol V. S.] Univ Sao Paulo, Sch Nursing, Grad Program Adult Hlth Nursing, Escola Enfermagem EEUSP, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Escola de
   Enfermagem da Universidade de Sao Paulo (EE-USP)
RP Milcheski, DA (通讯作者)，Univ Sao Paulo, Fac Med, Div Plast Surg, Sao Paulo, Brazil.
EM dimas.milcheski@hc.fm.usp.br; clivatti@gmail.com;
   rafaeljunior96@hotmail.com; carolvsgonzalez@gmail.com;
   araldo.junior@hc.fm.usp.br; rolf.gemperli@hc.fm.usp.br
RI SERNA GONZÁLEZ, CAROL VIVIANA/AAW-8858-2021; Milcheski,
   Dimas/OIU-4843-2025; Gemperli, Rolf/C-9116-2012
OI SERNA GONZÁLEZ, CAROL VIVIANA/0000-0002-9850-3030; 
FU Coordination for the Improvement of Higher Education Personnel (CAPES)
   through the Faculty of Medicine of the University of Sao Paulo [001];
   The 3M(R) Brazil and Global
FX This study was partially funded by the Coordination for the Improvement
   of Higher Education Personnel (CAPES), Financing Code 001, through the
   Faculty of Medicine of the University of Sao Paulo. Additionally, 3M (R)
   Brazil and Global provided financial support, including the supply of
   dressings used in the NPWT and NPWTi-d groups, Ulta machines, and
   funding for a clinical nurse. The funders had no role in the
   methodological design, data collection, analysis, or interpretation of
   the study results.
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   Kim PJ, 2020, INT WOUND J, V17, P1194, DOI 10.1111/iwj.13424
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Lavery LA, 2020, AM J SURG, V220, P1076, DOI 10.1016/j.amjsurg.2020.02.044
   Milcheski Dimas André, 2013, Rev. Col. Bras. Cir., V40, P392
   Milcheski Dimas André, 2010, Rev. Col. Bras. Cir., V37, P199
   Omar M, 2016, J WOUND CARE, V25, P475, DOI 10.12968/jowc.2016.25.8.475
   Rasband W.S., 1997, About us
   Schreiner W, 2020, ANN THORAC SURG, V110, P1722, DOI 10.1016/j.athoracsur.2020.04.037
   Team RC, 2017, RC. R: A language and environment for statistical computing
   Timmer AS, 2022, PLAST RECONSTR SURG, V150, p176E, DOI 10.1097/PRS.0000000000009232
   Wang GQ, 2023, INT WOUND J, V20, P1739, DOI 10.1111/iwj.13989
   Zwarenstein M, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a2390
NR 24
TC 6
Z9 7
U1 2
U2 7
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JAN
PY 2025
VL 100
BP 208
EP 218
DI 10.1016/j.bjps.2024.11.005
EA DEC 2024
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA P3C0F
UT WOS:001376719800001
PM 39644780
OA hybrid
DA 2026-07-24
ER
PT J
AU Jiang, MX
   Liang, WG
   Chen, XP
   Ge, YL
   Fang, YY
   Zhang, HT
   Jiang, RR
   Luo, BJ
AF Jiang, Mengxiao
   Liang, Wenguang
   Chen, Xiaoping
   Ge, Yonglan
   Fang, Yanyan
   Zhang, Huiting
   Jiang, Rongrong
   Luo, Baojia
TI Effective management of cervical anastomotic leakage post-esophageal
   cancer surgery using negative pressure wound therapy with saline
   instillation: A case report
SO ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
LA English
DT Article
DE Esophageal cancer; Anastomotic leakage; Negative pressure with
   instillation; Wound therapy
AB Cervical anastomotic leakage (AL) is a severe complication following esophageal cancer surgery, leading to significant morbidity and risk of mortality. This case report describes the successful application of negative pressure wound therapy with instillation (NPWTi) in managing AL after esophageal surgery. A 61-year-old patient developed an anastomotic leak on postoperative day 7, accompanied by persistent neck pain and leakage of nutritional fluids. Treatment involved a dual-tube NPWTi system with continuous saline instillation to clean and prevent infection, maintain wound moisture, and promote tissue granulation. Within 15 days, the leakage was substantially controlled, and a barium swallow test confirmed complete closure by day 20. This case suggests NPWTi as a promising and less invasive approach to managing AL post-esophagectomy, warranting further research on its clinical efficacy and safety.
C1 [Jiang, Mengxiao; Chen, Xiaoping; Ge, Yonglan; Fang, Yanyan; Zhang, Huiting; Jiang, Rongrong; Luo, Baojia] Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Canc, Nursing Dept, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China.
   [Liang, Wenguang] Sun Yat Sen Univ, Sch Nursing, Guangzhou, Peoples R China.
C3 Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen
   University
RP Zhang, HT; Jiang, RR; Luo, BJ (通讯作者)，Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Canc, Nursing Dept, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China.
EM Zhanght@sysucc.org.cn; Jiangrr@sysucc.org.cn; luobj@sysucc.org.cn
RI Chen, Xiaoping/NQF-2525-2025; Zhang, Huiting/IQW-3491-2023
OI Chen, Xiaoping/0009-0002-3306-2913; 
CR Afzal H, 2024, SURG INFECT, V25, P199, DOI 10.1089/sur.2023.299
   Ascari F, 2024, J GASTROINTEST SURG, V28, P1072, DOI 10.1016/j.gassur.2024.04.024
   Bray F, 2024, CA-CANCER J CLIN, V74, P229, DOI 10.3322/caac.21834
   De Pellegrin L, 2023, INT WOUND J, V20, P2402, DOI 10.1111/iwj.14072
   Fabbi M, 2021, DIS ESOPHAGUS, V34, DOI 10.1093/dote/doaa039
   Fernández LG, 2024, ADV WOUND CARE, V13, P416, DOI 10.1089/wound.2023.0113
   Fujisawa K, 2024, LARYNGOSCOPE, V134, P4573, DOI 10.1002/lary.31549
   Han BF, 2024, J NATL CANCER CTR, V4, P47, DOI 10.1016/j.jncc.2024.01.006
   Hauge T, 2024, DIS ESOPHAGUS, V37, DOI 10.1093/dote/doae040
   Hauge T, 2020, ACTA ONCOL, V59, P859, DOI 10.1080/0284186X.2020.1750694
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   Lange J, 2023, SURG ENDOSC, V37, P3657, DOI 10.1007/s00464-023-09861-7
   Leow Kimberley, 2020, Wounds, V32, pE120
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   Rosianu CG, 2023, LIFE-BASEL, V13, DOI 10.3390/life13040966
   Saini R, 2023, INDIAN J ORTHOP, V57, P1968, DOI 10.1007/s43465-023-01018-x
   Schuring N, 2023, EJSO-EUR J SURG ONC, V49, P97, DOI 10.1016/j.ejso.2022.07.020
   Seo HW, 2024, J CHEST SURG, V57, P152, DOI 10.5090/jcs.23.114
   Silverman Ronald P, 2023, Eplasty, V23, pe54
   Singh PK, 2023, LANGENBECK ARCH SURG, V409, DOI 10.1007/s00423-023-03202-x
   Sugawara K, 2022, GEN THORAC CARDIOVAS, V70, P1048, DOI 10.1007/s11748-022-01846-y
   Sun Haojie, 2024, J WOUND CARE, V33
   Ubels S, 2022, DIS ESOPHAGUS, V35, DOI 10.1093/dote/doac020
   van Geffen EGM, 2024, DIS ESOPHAGUS, V37, DOI 10.1093/dote/doae059
   Verstegen MHP, 2021, WORLD J SURG, V45, P3341, DOI 10.1007/s00268-021-06250-w
   Zhao JC, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-58900-3
   Zheng B, 2022, TRANSL LUNG CANCER R, V11, P331, DOI 10.21037/tlcr-22-141
NR 36
TC 0
Z9 0
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2347-5625
EI 2349-6673
J9 ASIA-PAC J ONCOL NUR
JI Asia-Pac. J. Oncol. Nurs.
PD DEC
PY 2025
VL 12
AR 100623
DI 10.1016/j.apjon.2024.100623
EA DEC 2024
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA P4T9K
UT WOS:001377862500001
PM 39717627
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rose, V
   Haram, NH
   Gallala, S
AF Rose, Victoria
   Haram, Nadine Hachah
   Gallala, Sarah
TI A new portable negative pressure wound therapy device: a prospective
   study investigating clinical outcomes
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE closed incision negative pressure wound therapy; closed surgical
   incision; exudate management; NPWT; single-use negative pressure wound
   therapy system; wound; wound care; wound dressing; wound healing
ID CLOSED INCISION MANAGEMENT; SURGICAL-SITE INFECTION; METAANALYSIS; HIP
AB Objective: Closed surgical incision sites at high risk of complications, and with exudate or leakage, are increasingly being managed with closed incision negative pressure wound therapy (ciNPWT) to reduce tissue stress and increase the force necessary to disrupt the incision. This study was undertaken to investigate the performance and safety of a canister-based, single-use NPWT (suNPWT) system when used on closed surgical incision sites. Method: The investigation was designed as a prospective, open, non-comparative, multicentre study aimed at confirming the safety and performance attributes of the suNPWT system when applied to low-to-moderately exuding closed surgical incisions. The primary performance measure was the wound remaining closed from baseline to the last follow-up visit on day 14. Secondary performance measures included: wound and periwound condition; wear time of the system; product consumption; adherence to therapy; and patients' pain progress. Details of adverse events were also collected. Results: Some 35 patients were recruited. The closed surgical incisions responded well to treatment with the tested suNPWT system. All wounds remained closed throughout the investigation. Consistent with other studies of ciNPWT reporting low infection rates, the current study observed either no or low exudation in 90.4% of wounds at the final visit, together with absence of surgical site infection. Pain severity levels were low, both at dressing change and during delivery of negative pressure. No serious adverse device events were reported. Conclusion: In this study, the suNPWT system supported the healing of closed surgical incisions with no safety concerns relating to its use.
C1 [Rose, Victoria; Haram, Nadine Hachah] Guys & St Thomas Hosp NHS Trust, London, England.
   [Gallala, Sarah] UZ Brussel, Wondklin TAV Valerie Hanssens, Jette, Belgium.
C3 University Hospital Brussels
RP Haram, NH (通讯作者)，Guys & St Thomas Hosp NHS Trust, London, England.
EM Nadine.HachachHaram@gstt.nhs.uk
OI Haram, Nadine/0009-0006-6197-6172; Rose, Victoria/0000-0003-0166-9470
FU Molnlycke Health Care, Sweden
FX The study was sponsored by Molnlycke Health Care, Sweden. The authors
   have no conflicts of interest.
CR Ailaney N, 2021, J ARTHROPLASTY, V36, P2402, DOI 10.1016/j.arth.2020.11.039
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NR 33
TC 2
Z9 2
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2024
VL 33
IS 11
BP 833
EP 840
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA P5L7G
UT WOS:001378328800005
PM 39480726
DA 2026-07-24
ER
PT J
AU González-Muñoz, A
   Vallejo-Soto, JC
   Barragán-Pinilla, JD
   Pesce, A
   Ramírez-Giraldo, C
AF Gonzalez-Munoz, Alejandro
   Vallejo-Soto, Juan Carlos
   Barragan-Pinilla, Juan Diego
   Pesce, Antonio
   Ramirez-Giraldo, Camilo
TI Factors related to successful mesh salvage with negative pressure wound
   therapy: a retrospective cohort study
SO HERNIA
LA English
DT Article
DE Hernia; Mesh infection; Wound infection; Mesh salvage; Negative pressure
   wound therapy; NPWT
ID EPIDEMIOLOGY; PREDICTORS; INFECTION
AB BackgroundMesh salvage using negative pressure wound therapy (NPWT) in cases of mesh infection following hernia repair has emerged as an alternative to early mesh removal. However, the factors related to the success or failure of mesh salvage with NPWT remain unclear.MethodsThis retrospective cohort study included 61 patients with mesh infections after hernia repair treated with NPWT between 2018 and 2024. We analyzed demographic, clinical, and surgical variables, as well as the bacterial spectrum and antimicrobial susceptibility. A binary logistic regression model was used to identify factors associated with NPWT failure, defined as the need for mesh removal.ResultsMesh salvage was successful in 80.3% of cases. Active smoking was significantly associated with NPWT failure (OR = 7.82, CI 95% 1.05-64.8; p = 0.044). Other factors, such as age, body mass index, Charlson comorbidity index, mesh type, and mesh position, were not significantly related to failure. Most infections were caused by Staphylococcus aureus (24.6%) and Escherichia coli (22.9%).ConclusionsNPWT is an effective method for salvaging infected meshes, with a high success rate. Active smoking was identified as a risk factor for NPWT failure, highlighting the need for early identification of patients who may benefit from alternative approaches. Further studies are required to develop predictive models for NPWT success in mesh salvage.
C1 [Gonzalez-Munoz, Alejandro; Ramirez-Giraldo, Camilo] Hosp Univ Mayor Mederi, Bogota, Colombia.
   [Gonzalez-Munoz, Alejandro; Vallejo-Soto, Juan Carlos; Barragan-Pinilla, Juan Diego; Ramirez-Giraldo, Camilo] Univ Rosario, Bogota, Colombia.
   [Pesce, Antonio] Univ Ferrara, Dept Surg, Azienda Unita Sanit Locale Ferrara, Via Valle Oppio 2, I-44023 Lagosanto, FE, Italy.
C3 Universidad del Rosario; University of Ferrara
RP Ramírez-Giraldo, C (通讯作者)，Hosp Univ Mayor Mederi, Bogota, Colombia.; Ramírez-Giraldo, C (通讯作者)，Univ Rosario, Bogota, Colombia.
EM ramirezgiraldocamilo@gmail.com
RI Ramírez-Giraldo, Camilo/LRV-0499-2024; PESCE, ANTONIO/G-4536-2017
OI Ramírez-Giraldo, Camilo/0000-0002-1929-2299; PESCE,
   ANTONIO/0000-0002-7560-551X; Vallejo-Soto, Juan
   Carlos/0009-0006-1950-194X; Gonzalez Muñoz,
   Alejandro/0000-0003-3890-3726
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Ashour O, 2023, SURGERY, V173, P1452, DOI 10.1016/j.surg.2023.02.017
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   Bueno-Lledó J, 2017, AM J SURG, V213, P50, DOI 10.1016/j.amjsurg.2016.03.007
   Gao JR, 2021, J ADV NURS, V77, P3980, DOI 10.1111/jan.14876
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NR 21
TC 2
Z9 2
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD DEC 4
PY 2024
VL 29
IS 1
AR 42
DI 10.1007/s10029-024-03233-3
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA P6Q7H
UT WOS:001379136200001
PM 39633022
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Lou, JQ
   Zhu, XY
   Xiang, ZY
   Fan, YF
   Song, JY
   Huang, N
   Li, JL
   Jin, GY
   Cui, SY
AF Lou, Jiaqi
   Zhu, Xiaoyu
   Xiang, Ziyi
   Fan, Youfen
   Song, Jingyao
   Huang, Neng
   Li, Jiliang
   Jin, Guoying
   Cui, Shengyong
TI The efficacy and safety of negative pressure wound therapy in paediatric
   burns: a systematic review and meta-analysis of randomized controlled
   trials
SO BMC PEDIATRICS
LA English
DT Article
DE Negative pressure wound therapy; Paediatric burns; Vacuum sealing
   drainage; Healing time; Complications; Meta-analysis
ID KNEE ARTHROPLASTY; SKIN-GRAFTS; INSTILLATION; DRESSINGS
AB BackgroundAlthough the effective application of negative pressure wound therapy (NPWT) has been exemplified in diverse clinical studies, its potential and safety, specifically regarding paediatric burns, are yet to be fully confirmed. Our most recent systematic review and meta-analysis strive to investigate the impact of NPWT within the realm of paediatric burns. MethodsWe sourced relevant articles from databases including PubMed, Embase, the Cochrane Database, Web of Science, the International Clinical Trials Registry Platform, China National Knowledge Infrastructureris, the VIP Database for Chinese Technical Periodicals, and the Wanfang database. We defined the primary outcome measure as the healing time, while healing rate, numbers of dressing changes, detection rate of positive bacteria, incidence rate of adverse reactions, scar scale scores, and treatment costs were considered as secondary outcome measures. Pooling of data was conducted and the results were articulated as relative risk (RR), mean difference (MD), and standardized mean difference (SMD), all with a 95% confidence interval (CI). ResultsIn this systematic review and meta-analysis, a total of 12 studies involving 1033 individuals were examined, including 559 paediatric burn patients who underwent NPWT (referred to as the treatment group) and 543 patients who received treatments other than NPWT (referred to as the control group). The amalgamated data from these studies exhibited that the treatment group experienced significant reductions in healing time (SMD = -1.60; 95% CI: -2.26 - -0.95; p < 0.001, I2 = 92.8%), the number of required dressing changes (SMD = -4.6; 95% CI: -5.84 - -3.36; p < 0.001, I2 = 92.4%), positive bacteria detection rate (RR = 0.61; 95% CI: 0.26-1.46; p = 0.004, I2 = 81.8%), incidence of adverse reactions (RR = 0.61; 95% CI: 0.33-1.12; p = 0.005, I2 = 68%), scar scale scores (SMD = -1.66; 95% CI: -2.54 - -0.79; p < 0.001, I2 = 89.4%), as well as in treatment costs (SMD = 0.92; 95% CI: -1.66-3.49; p < 0.001, I2 = 98.4%). Additionally, these individuals showed an increased rate of healing (RR = 1.17; 95% CI: 0.99-1.39; p < 0.001, I2 = 78%). Subgroup analysis did not find that the degree of burn was one of the sources of high heterogeneity. ConclusionOur meta-analysis points to the effectiveness of NPWT in treating paediatric burns. Notably, it significantly mitigates healing duration, frequency of dressing alterations, positive bacterial detection rate, adverse reactions incidence, scar scale scores and treatment costs, all while propelling the acceleration of wound healing.
C1 [Lou, Jiaqi; Fan, Youfen; Huang, Neng; Li, Jiliang; Jin, Guoying; Cui, Shengyong] Ningbo No 2 Hosp, Burn Dept, 41 Northwest St, Ningbo 315010, Zhejiang, Peoples R China.
   [Zhu, Xiaoyu] Ningbo Univ, Hlth Sci Ctr, Ningbo, Zhejiang, Peoples R China.
   [Xiang, Ziyi] Univ Bonn, Fac Med, Dept Psychiat & Psychotherapy, Sect Med Psychol, D-53127 Bonn, Germany.
   [Song, Jingyao] Wenzhou Med Univ, Sch Mental Hlth, Whenzhou, Zhejiang, Peoples R China.
C3 Ningbo University; University of Bonn; Wenzhou Medical University
RP Cui, SY (通讯作者)，Ningbo No 2 Hosp, Burn Dept, 41 Northwest St, Ningbo 315010, Zhejiang, Peoples R China.
EM csy00544@163.com
RI Lou, Jiaqi/GSN-0304-2022
OI Lou, Jiaqi/0000-0003-1316-7507
FU Project of NINGBO Leading Medical & Health Discipline
FX Not applicable.
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NR 70
TC 13
Z9 15
U1 1
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD DEC 18
PY 2024
VL 24
IS 1
AR 807
DI 10.1186/s12887-024-05302-z
PG 27
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA P9K8J
UT WOS:001381014700005
PM 39696096
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Cimmino, AA
   Marangi, GF
   D'Onofrio, G
   Gratteri, M
   Porso, D
   Romano, FD
   Mirra, C
   Persichetti, P
AF Cimmino, Andrea Aniello
   Marangi, Giovanni Francesco
   D'Onofrio, Gianluca
   Gratteri, Marco
   Porso, Daniela
   Romano, Fara Desiree
   Mirra, Carlo
   Persichetti, Paolo
TI Total Capsulectomy and NPWT for Management of a Mycobacterium abscessus
   Breast Implant Infection Unresponsive to Antimicrobial Therapy A Case
   Report and Literature Review
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE breast implant infection; mycobacterial infection; wound management;
   negative pressure wound therapy
ID AUGMENTATION MAMMAPLASTY; SURGERY
AB Background. Nontuberculous mycobacteria (NTM) periprosthetic infections after breast augmentation procedures are increasingly common worldwide and should raise suspicion after empirical antimicrobial therapy fails but clinical signs of infection persist. In this case experience, the authors suggest the use of negative pressure wound therapy (NPWT) for NTM-infected wounds to obtain a faster periprosthetic space closure, shorten healing time, and anticipate breast reimplantation. Case Report. This case report describes the successful application of NPWT to manage wound healing after breast implant removal in a 60-year-old female who underwent secondary breast augmentation 7 years before. The patient presented with an Mycobacterium abscessus infection of the left breast after lung segmentectomy that persisted post-implant removal and targeted antibiotic therapy. Based on clinical and laboratory findings, the authors opted for a debridement of the periprosthetic space associated to a radical capsulectomy. Application of NPWT for wound drainage and closure allowed a faster recovery, reduced interval from implant removal to reimplantation, and led to a pleasant cosmetic result. Conclusion. The use of NPWT for wound management after NTM peri-implant infection may help to encourage faster periprosthetic space drainage and closure, thus expediting the timing of a negative culture and breast reimplantation.
C1 [Cimmino, Andrea Aniello; Marangi, Giovanni Francesco; D'Onofrio, Gianluca; Gratteri, Marco; Porso, Daniela; Romano, Fara Desiree; Mirra, Carlo; Persichetti, Paolo] Univ Campus Biomed Roma, Dept Plast Reconstruct & Aesthet Surg, Rome, Italy.
C3 University Campus Bio-Medico - Rome Italy
RP Cimmino, AA (通讯作者)，Campus Biomed Univ Rome, Unit Plast & Reconstruct Surg, Via Alvaro del Portillo 200, I-00128 Rome, Italy.
EM andrea.cimmino@unicampus.it
RI Gratteri, Marco/KGM-5481-2024; Marangi, Giovanni/AAW-4723-2020
CR Al-Halabi B, 2018, PLAST RECONSTR SURG, V142, p639E, DOI 10.1097/PRS.0000000000004892
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NR 23
TC 2
Z9 2
U1 1
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2024
VL 36
IS 11
BP 392
EP 396
DI 10.25270/wnds/24033
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA P9O6Z
UT WOS:001381115100006
PM 39666907
DA 2026-07-24
ER
PT J
AU Hill, R
AF Hill, Rosemary
TI Efficiency of New Smart Instillation Technology With Negative Pressure
   Wound Therapy in Managing Complex Chronic and Surgical Wounds: A Case
   Series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE complex wound management; infected wounds; negative pressure wound
   therapy with instillation and dwell time; reticulated open cell foam
   dressing with through holes
ID RECOMMENDATIONS
AB Background. Use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) of a topical wound solution has been limited in some settings due to perceptions of setup complexity. Typically, some guesswork was needed to estimate an adequate volume of solution to instill without causing leaks. A novel smart technology is recently available in certain NPWTi-d systems that automatically estimates and instills a solution volume according to wound dimensions. Objective. To report experience with this smart instillation NPWTi-d system technology in managing 4 complex wounds containing large areas of devitalized tissue and/or yellow fibrinous slough. Materials and Methods. NPWTi-d was applied via a reticulated open cell foam dressing with through holes (ROCF-CC). The smart instill button was selected to automatically determine a volume of topical solution to instill, followed by a 10-minute dwell time and 2-hour cycle of -125 mm Hg negative pressure. Results. The average NPWTi-d duration was 17.0 days, and no air or solution leaks occurred during therapy. Dressings were changed 3 times per week. All wounds were converted to clean granulating wounds during therapy. Conclusion. In this case series, smart technology simplified setup and facilitated regular cleansing and removal of devitalized tissue through the ROCF-CC dressing.
C1 [Hill, Rosemary] Lions Gate Hosp, N Vancouver, BC, Canada.
RP Hill, R (通讯作者)，Vancouver Coastal Hlth, Lions Gate Hosp, 231 15th St E, N Vancouver, BC V7L 2L7, Canada.
EM Rosemary.hill@vch.ca
CR Diehm YF, 2021, PLAST RECONSTR SURG, V147, p43S, DOI 10.1097/PRS.0000000000007610
   Kim PJ, 2023, WOUNDS, V35, pE82, DOI 10.25270/wnds/22029
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   McKanna M, 2016, OSTOMY WOUND MANAG, P3
   Sen CK, 2023, ADV WOUND CARE, V12, P657, DOI 10.1089/wound.2023.0150
   Silverman Ronald P, 2023, Eplasty, V23, pe54
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
NR 7
TC 0
Z9 0
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2024
VL 36
IS 11
BP 397
EP 401
DI 10.25270/wnds/24125
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA P9O6Z
UT WOS:001381115100007
PM 39666908
DA 2026-07-24
ER
PT J
AU Liu, YT
   Lin, SH
   Peng, C
   Huang, RW
   Lin, CH
   Hsu, CC
   Chen, SH
   Lin, YT
   Lee, CH
AF Liu, Yen-Ting
   Lin, Shih-Han
   Peng, Chi
   Huang, Ren-Wen
   Lin, Cheng-Hung
   Hsu, Chung-Chen
   Chen, Shih-Heng
   Lin, Yu-Te
   Lee, Che-Hsiung
TI Effectiveness and safety of negative pressure wound therapy in patients
   with deep sternal wound infection: a systematic review and meta-analysis
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Review
DE chest wall reconstruction; deep sternal wound infection; meta-analysis;
   negative pressure wound therapy; systematic review; vacuum-assisted
   closure
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; POSTSTERNOTOMY
   MEDIASTINITIS; CONVENTIONAL THERAPY; SUCTION DRAINAGE; CLOSED DRAINAGE;
   CARDIAC-SURGERY; MUSCLE FLAPS; MANAGEMENT; MORTALITY
AB Background: Deep sternal wound infection (DSWI) is a severe and life-threatening complication following cardiovascular surgery. Negative pressure wound therapy (NPWT) has emerged as a promising therapeutic bridging option for DSWI. In this systematic review and meta-analysis, the authors aimed to evaluate the impact of NPWT on clinical outcomes in patients with DSWI. Material and Methods: A comprehensive literature search was conducted according to the PRISMA guideline in electronic databases, including PubMed, Embase, and Cochrane Library. Data extraction was performed independently by two reviewers, and risk of bias was assessed by ROBINS-I tool. The primary outcomes assessed were mortality rate and reinfection rate. The secondary outcomes assessed were length of hospital stay and ICU stay. Results: In this systematic review identified a total of 36 studies, comprising 3681 patients with DSWI who received treatment. The meta-analysis revealed that NPWT was associated with a significant reduction in mortality rate (RR 0.46, 95% CI: 0.35-0.61, P<0.000001) and reinfection rate (RR 0.43, 95% CI: 0.25-0.74, P=0.002) compared to conventional wound management. Furthermore, pooling of these studies showed significant difference between the NPWT and conventional treatment groups in length of hospital stay (mean difference: -4.49, 95% CI: -8.14 to -0.83; P=0.02) and length of ICU stay (mean difference: -1.11, 95% CI: -2.18 to -0.04; P=0.04). Conclusion: This systematic review and meta-analysis provide evidence that NPWT is superior to conventional treatment for patients with DSWI following cardiovascular surgery.
C1 [Liu, Yen-Ting; Peng, Chi; Huang, Ren-Wen; Lin, Cheng-Hung; Hsu, Chung-Chen; Chen, Shih-Heng; Lin, Yu-Te; Lee, Che-Hsiung] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, 5 Fu Shin St Kwei Shan, Taoyuan 333, Taiwan.
   [Lin, Shih-Han] Chang Gung Univ, Sch Med, Taoyuan, Taiwan.
   [Lin, Cheng-Hung] Chang Gung Mem Hosp, Ctr Vascularized Composite Allotransplantat, Taoyuan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital
RP Lee, CH (通讯作者)，Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, 5 Fu Shin St Kwei Shan, Taoyuan 333, Taiwan.
EM yentingliu1023@gmail.com; alpha1091143@gmail.com; t359685@gmail.com;
   aaronhuang0327@gmail.com; lukechlin@gmail.com; hsu.chungchen@gmail.com;
   shihheng@icloud.com; linutcgmh@gmail.com; ikemanleee@gmail.com
RI Huang, Ren-Wen/IVH-7970-2023; Lee, Che-Hsiung/KOJ-5866-2024; Liu,
   Yen-Ting/ABB-1470-2020
OI Huang, Ren-Wen/0000-0002-3074-6570; Lin, Shihhan/0009-0001-6031-1711;
   Lin, Cheng-Hung/0000-0001-7278-093X; 劉, 彥廷/0009-0008-0236-2490; Lee,
   Che-Hsiung/0000-0002-6164-4884; 
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NR 75
TC 6
Z9 8
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD DEC
PY 2024
VL 110
IS 12
BP 8107
EP 8125
DI 10.1097/JS9.0000000000002138
PG 19
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA P9O7P
UT WOS:001381116700032
PM 39806749
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Zhang, YZ
   Wu, WJ
   Shu, YJ
   Su, QY
   Wang, F
   Han, B
AF Zhang, Yuezhu
   Wu, Wenjie
   Shu, Yanjia
   Su, Qianya
   Wang, Fei
   Han, Bing
TI Vacuum sealing drainage successfully treated refractory sclerosing
   panniculitis
SO CLINICAL AND EXPERIMENTAL DERMATOLOGY
LA English
DT Article
AB Here, we describe a patient with refractory sclerosing panniculitis with a long disease course who was successfully treated using vacuum sealing drainage (VSD). As demonstrated in this patient, VSD has a favourable therapeutic effect on sclerosing panniculitis. It is reasonable to consider that VSD represents a safe and effective technique for the treatment of sclerosing panniculitis.
C1 [Zhang, Yuezhu; Wu, Wenjie; Shu, Yanjia; Su, Qianya; Wang, Fei] Southeast Univ, ZhongDa Hosp, Sch Med, Dept Dermatol, Nanjing, Peoples R China.
   [Han, Bing] Southeast Univ, ZhongDa Hosp, Sch Med, Dept Plast Surg, Nanjing, Peoples R China.
C3 Southeast University - China; Southeast University - China
RP Han, B (通讯作者)，Southeast Univ, ZhongDa Hosp, Sch Med, Dept Plast Surg, Nanjing, Peoples R China.
EM hanbingseven@seu.edu.cn
RI Su, Qianya/ABH-1425-2021
FU Southeast University Affiliated Zhongda Hospital; Affiliated to
   Southeast University, Jiangsu Province High-Level Hospital Construction
   Funds [2024GSPKY18]
FX This study was funded by Southeast University Affiliated Zhongda
   Hospital, Affiliated to Southeast University, Jiangsu Province
   High-Level Hospital Construction Funds, grant no. 2024GSPKY18.
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   Zhang L, 2020, EXP THER MED, V20, P2305, DOI 10.3892/etm.2020.8941
NR 5
TC 0
Z9 1
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0307-6938
EI 1365-2230
J9 CLIN EXP DERMATOL
JI Clin. Exp. Dermatol.
PD DEC 24
PY 2024
VL 50
IS 3
BP 714
EP 716
DI 10.1093/ced/llae442
EA DEC 2024
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA Y3Z8D
UT WOS:001382405300001
PM 39414252
DA 2026-07-24
ER
PT J
AU Nachira, D
   Calabrese, G
   Senatore, A
   Pontecorvi, V
   Kuzmych, K
   Belletatti, C
   Boskoski, I
   Meacci, E
   Biondi, A
   Raveglia, F
   Bove, V
   Congedo, MT
   Vita, ML
   Santoro, G
   Ciavarella, LP
   Lococo, F
   Punzo, G
   Trivisonno, A
   Petrella, F
   Barbaro, F
   Spada, C
   D'Ugo, D
   Cioffi, U
   Margaritora, S
AF Nachira, Dania
   Calabrese, Giuseppe
   Senatore, Alessia
   Pontecorvi, Valerio
   Kuzmych, Khrystyna
   Belletatti, Claudia
   Boskoski, Ivo
   Meacci, Elisa
   Biondi, Alberto
   Raveglia, Federico
   Bove, Vincenzo
   Congedo, Maria Teresa
   Vita, Maria Letizia
   Santoro, Gloria
   Petracca Ciavarella, Leonardo
   Lococo, Filippo
   Punzo, Giovanni
   Trivisonno, Angelo
   Petrella, Francesco
   Barbaro, Federico
   Spada, Cristiano
   D'Ugo, Domenico
   Cioffi, Ugo
   Margaritora, Stefano
TI How to preserve the native or reconstructed esophagus after perforations
   or postoperative leaks: A multidisciplinary 15-year experience
SO WORLD JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article
DE Esophageal perforations; Postoperative leak; Endoscopic vacuum-assisted
   closure therapy; Metal stent; Endoscopic suture; Lateral esophagostomy;
   Autologous emulsified stromal vascular fraction
ID ENDOSCOPIC CLOSURE; ANASTOMOTIC LEAKS; CLIP APPLICATION; MANAGEMENT;
   EFFICACY; ESOPHAGECTOMY; FISTULAS; SURGERY; STENTS
AB BACKGROUND Esophageal perforation or postoperative leak after esophageal surgery remain a life-threatening condition. The optimal management strategy is still unclear. AIM To determine clinical outcomes and complications of our 15-year experience in the multidisciplinary management of esophageal perforations and anastomotic leaks. METHODS A retrospective single-center observational study was performed on 60 patients admitted at our department for esophageal perforations or treated for an anastomotic leak developed after esophageal surgery from January 2008 to December 2023. Clinical outcomes were analyzed, and complications were evaluated to investigate the efficacy and safety of our multidisciplinary management based on the preservation of the native or reconstructed esophagus, when feasible. RESULTS Among the whole series of 60 patients, an urgent surgery was required in 8 cases due to a septic state. Fifty-six patients were managed by endoscopic or hybrid treatments, obtaining the resolution of the esophageal leak/perforation without removal of the native or reconstructed esophagus. The mean time to resolution was 54.95 +/- 52.64 days, with a median of 35.5 days. No severe complications were recorded. Ten patients out of 56 (17.9%) developed pneumonia that was treated by specific antibiotic therapy, and in 6 cases (10.7%) an atrial fibrillation was recorded. Seven patients (12.5%) developed a stricture within 12 months, requiring one or two endoscopic pneumatic dilations to solve the problem. Mortality was 1.7%. CONCLUSION A proper multidisciplinary approach with the choice of the most appropriate treatment can be the key for success in managing esophageal leaks or perforations and preserving the esophagus.
C1 [Nachira, Dania; Calabrese, Giuseppe; Senatore, Alessia; Kuzmych, Khrystyna; Belletatti, Claudia; Meacci, Elisa; Congedo, Maria Teresa; Vita, Maria Letizia; Petracca Ciavarella, Leonardo; Lococo, Filippo; Margaritora, Stefano] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Gen Thorac Surg, Largo A Vito 8, I-00168 Rome, Italy.
   [Pontecorvi, Valerio; Boskoski, Ivo; Bove, Vincenzo; Barbaro, Federico; Spada, Cristiano] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli IRCCS, Digest Endoscopy Unit, I-00168 Rome, Italy.
   [Biondi, Alberto] Fdn Policlin Univ Agostino Gemelli IRCCS, Gen Surg Unit, I-00168 Rome, Italy.
   [Raveglia, Federico; Petrella, Francesco] IRCCS San Gerardo Tintori, Dept Thorac Surg, I-20900 Monza, Lombardy, Italy.
   [Santoro, Gloria] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Surg, I-00168 Rome, Italy.
   [Punzo, Giovanni] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Anesthesiol & Intens Care Med, I-00168 Rome, Italy.
   [Trivisonno, Angelo] Assunz Maria Santissima Clin, Dept Plast Surg, I-00135 Rome, Italy.
   [D'Ugo, Domenico] Agostino Gemelli Univ Hosp, Catholic Univ Rome, Dept Surg, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Fondazione IRCCS San Gerardo dei Tintori; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli
RP Nachira, D (通讯作者)，Univ Cattolica Sacro Cuore IRCCS, Fdn Policlin Univ Agostino Gemelli, Dept Gen Thorac Surg, Largo A Vito 8, I- 00135 Rome, Italy.
EM dania.nachira@policlinicogemelli.it
RI Boskoski, Ivo/A-9629-2014; meacci, elisa/IQT-4087-2023; Nachira,
   Dania/AAO-4264-2020; Biondi, Alberto/K-4781-2018; Bove,
   Vincenzo/ABD-9730-2020; Kuzmych, Khrystyna/NNG-1141-2025; Barbaro,
   Federico/HNS-1515-2023; Pontecorvi, Valerio/AAB-8594-2022; Petrella,
   Francesco/AAP-6480-2020; Raveglia, Federico/J-9512-2019; D'Ugo,
   Domenico/AAB-7038-2019; Vita, Maria/F-5801-2019; congedo, maria
   teresa/K-8809-2016
OI Punzo, Giovanni/0000-0002-4640-5885; Bellettati,
   Claudia/0009-0000-2458-6657; Kuzmych, Khrystyna/0000-0001-6399-9171;
   Barbaro, Federico/0000-0002-7928-3757; Pontecorvi,
   Valerio/0000-0003-3972-1828; Petracca Ciavarella,
   Leonardo/0000-0002-9659-1014; 
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NR 57
TC 1
Z9 3
U1 0
U2 1
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1948-9366
J9 WORLD J GASTRO SURG
JI World J. Gastrointest. Surg.
PD NOV 27
PY 2024
VL 16
IS 11
DI 10.4240/wjgs.v16.i11.3471
PG 14
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA Q1Q5T
UT WOS:001382518300011
PM 39649190
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gu, LC
   Peng, Y
   Zhang, Y
   Gong, XY
   Su, T
   Chen, GX
AF Gu, Ling-chuan
   Peng, Yang
   Zhang, Ying
   Gong, Xiao-yuan
   Su, Tiao
   Chen, Guang-xing
TI Enhancing treatment outcomes for Acute Periprosthetic Hip Joint
   infection: optimizing debridement, antibiotics, and Implant Retention
   through vacuum sealing drainage in the deep tissue
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE Periprosthetic joint infection; Vacuum sealing drainage; Debridement;
   Antibiotics
ID PRESSURE WOUND THERAPY; ASSISTED CLOSURE; BIOFILMS
AB BackgroundDebridement, antibiotics, and implant retention (DAIR) for acute periprosthetic joint infection (PJI) is under debated since the reported success rate is inconsistent. This study aimed to explore the efficacy of vacuum sealing drainage (VSD) used as an adjunct to irrigation and debridement for acute PJI.MethodsPatients undergoing debridement, irrigation with component retention, and application of vacuum seal drainage in the deep portion surrounding the infected sites from January 2014 to February 2021 were retrospectively reviewed. The definition of failure included the requirement of prosthesis removal; persistent infection-related symptoms; suppressive antibiotics therapy due to failure of controlling the infection; infection-related death.Results45 patients were included in this study with a mean follow-up of 45.62 +/- 13.87 months. There were 28 males and 17 females with a mean age of 63.29 +/- 17.74 months. The overall success rate was 86.67% with 6 failures. Multivariate analysis revealed a significant association between Charlson comorbidity index and treatment failure (OR = 2.226, 95% CI, 1.057-4.687, p = 0.035).ConclusionsThe incorporation of VSD in the deeper region enhances the outcomes of DAIR, achieving an 86.67% success rate in managing acute PJI. This approach offers a potentially safe and effective treatment, though patients with higher Charlson comorbidity index and elevated preoperative CRP levels face increased risks of failure.
C1 [Gu, Ling-chuan; Peng, Yang; Zhang, Ying; Gong, Xiao-yuan; Su, Tiao; Chen, Guang-xing] Army Med Univ, Southwest Hosp, Ctr Joint Surg, Intelligent Mfg & Rehabil Engn Ctr, Gaotanyan St, Chongqing 400038, Peoples R China.
   [Gu, Ling-chuan; Peng, Yang; Zhang, Ying; Gong, Xiao-yuan; Su, Tiao; Chen, Guang-xing] Chongqing Municipal Sci & Technol Bur Key Lab Prec, Chongqing 400038, Peoples R China.
   [Gu, Ling-chuan; Peng, Yang; Zhang, Ying; Gong, Xiao-yuan; Su, Tiao; Chen, Guang-xing] Chongqing Municipal Educ Commiss Key Lab Joint Bio, Chongqing 400038, Peoples R China.
C3 Army Medical University
RP Gong, XY; Su, T; Chen, GX (通讯作者)，Army Med Univ, Southwest Hosp, Ctr Joint Surg, Intelligent Mfg & Rehabil Engn Ctr, Gaotanyan St, Chongqing 400038, Peoples R China.; Gong, XY; Su, T; Chen, GX (通讯作者)，Chongqing Municipal Sci & Technol Bur Key Lab Prec, Chongqing 400038, Peoples R China.; Gong, XY; Su, T; Chen, GX (通讯作者)，Chongqing Municipal Educ Commiss Key Lab Joint Bio, Chongqing 400038, Peoples R China.
EM glc@tmmu.edu.cn; pengyang1027@tmmu.edu.cn; zhang.ying@live.cn;
   xiaoyuangong123@tmmu.edu.cn; hhhhst@tmmu.edu.cn; cgx7676@tmmu.edu.cn
RI Su, Tiao/GQO-8162-2022
OI Peng, Yang/0000-0002-6562-1233
FU National Natural Science Foundation of China General Program [82372365];
   Chongqing Natural Science Foundation Innovation Development Joint Fund
   Project [CSTB2022NSCQ-LZX0066]
FX This study was funded by the National Natural Science Foundation of
   China General Program (82372365), Chongqing Natural Science Foundation
   Innovation Development Joint Fund Project (CSTB2022NSCQ-LZX0066).
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NR 31
TC 2
Z9 2
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD DEC 16
PY 2024
VL 145
IS 1
AR 54
DI 10.1007/s00402-024-05649-z
PG 9
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA Q1Z1F
UT WOS:001382740500001
PM 39680189
DA 2026-07-24
ER
PT J
AU Li, S
   Xu, XP
AF Li, Sen
   Xu, Xiuping
TI The role of the medial head of the gastrocnemius myocutaneous flap
   transfer in the management of prosthesis exposure and deep joint
   infection following total knee arthroplasty
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE Total knee arthroplasty; Medial head of the gastrocnemius myocutaneous
   flap transfer; Prosthesis exposure; Deep joint infection; Vacuum sealing
   drainage
AB BackgroundThere is a lack of effective and innovative treatment for patients with prosthesis exposure and deep joint infection following total knee arthroplasty. This study explores the application of the medial head of the gastrocnemius myocutaneous flap transfer in these conditions, offering new therapeutic strategies for clinical practice.MethodsClinical data of 68 patients with prosthesis exposure and deep joint infection following total knee arthroplasty were included and retrospectively analyzed. Patients were divided into one study group (n = 35, received medial head of the gastrocnemius myocutaneous flap transfer and vacuum sealing drainage) and one control group (n = 33, received vacuum sealing drainage). The total effective rates, visual analogue scale (VAS), Hospital for Special Surgery score (HSS), knee joint function, activity, inflammatory reactions, safety, and recurrence rate were compared between the two groups.ResultsThe total effective rate in the study group was higher than that in the control group. VAS scores in the study group were lower at 3 and 7 days after treatment. HSS scores were higher in the study group after treatment. The study group showed lower levels of hs-CRP and IL-6 after treatment. At 1 month and 3 months after treatment, the study group exhibited higher knee joint activity. There was no difference in the incidence of adverse reactions between the two groups, and the study group had a lower recurrence rate.ConclusionMedial head of the gastrocnemius myocutaneous flap transfer effectively improves knee joint function and activity, reduces pain, alleviates inflammatory reactions, and has fewer adverse reactions and a lower recurrence rate.
C1 [Li, Sen] Gansu Prov Hosp TCM, Hand Surg Two, 418 Guazhou Rd, Lanzhou City 730000, Gansu Province, Peoples R China.
   [Xu, Xiuping] Gansu Prov Hosp TCM, Emergency Ctr, Lanzhou City, Gansu Province, Peoples R China.
RP Li, S (通讯作者)，Gansu Prov Hosp TCM, Hand Surg Two, 418 Guazhou Rd, Lanzhou City 730000, Gansu Province, Peoples R China.
EM woshiliseng@163.com; woshixuxiuping1989@163.com
CR [Anonymous], 2017, Megaprosthesis of the knee in tumor and revision surgery, V88, P129, DOI [10.23750/abm.v88i2.-S.6523, DOI 10.23750/ABM.V88I2.-S.6523]
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NR 30
TC 0
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD DEC 12
PY 2024
VL 145
IS 1
AR 26
DI 10.1007/s00402-024-05679-7
PG 9
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA Q1Z1I
UT WOS:001382740800005
PM 39666049
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Yatsun, V
   Yatsun, O
AF Yatsun, Vladyslav
   Yatsun, Oleksandr
TI Detection and Successful Treatment of Gunshot Wound to the Femoral
   Artery and Vein Four Days Post-incident: A Case Study
SO MILITARY MEDICINE
LA English
DT Article
AB This case study presents the successful treatment of a 26-year-old male who experienced profuse bleeding from a gunshot wound to his thigh 4 days after the initial injury. The patient underwent surgery performed by a military vascular surgeon, during which previously undetected injuries to the femoral artery and vein were identified. The surgeon conducted a femoral artery alloprosthesis and sutured the damaged femoral vein. Following the surgery, the patient received post-operative conservative treatment and vacuum-assisted closure therapy, resulting in no complications or development of irreversible ischemic manifestation. The clinical case demonstrates the possible positive effects of placing an endovascular balloon in the main artery (more proximal lesion) for prolonged bleeding control without the use of a tourniquet. In this case, the role of the endovascular balloon was played by a hematoma. As a result, the lower extremity survived 4 days before the arterial blood flow reconstruction was done. Although such a model of bleeding control is absolutely unacceptable for planned specialized surgery or even military surgery at a medical assistance level of II-III, it may be considered as a lifesaving measure when surgical intervention is not immediately available.
C1 [Yatsun, Vladyslav] Natl Mil Med Clin Ctr MMCH, Vasc Surg Clin, Minist Def Ukraine, UA-02138 Kyiv, Ukraine.
   [Yatsun, Oleksandr] Ukrainian Red Cross, Emergency Response Team, UA-07301 Vyshgorod, Kyiv, Ukraine.
RP Yatsun, V (通讯作者)，Natl Mil Med Clin Ctr MMCH, Vasc Surg Clin, Minist Def Ukraine, UA-02138 Kyiv, Ukraine.
EM vyacun@gmail.com
OI Yatsun, Vladyslav/0009-0000-6320-5108
CR Blackbourne LH, 2012, J TRAUMA ACUTE CARE, V73, pS378, DOI 10.1097/TA.0b013e3182754900
   Blackbourne LH, 2012, J TRAUMA ACUTE CARE, V73, pS372, DOI 10.1097/TA.0b013e3182755662
   Drew B, 2020, Journal of Special Operations Medicine, V20, P144, DOI [10.55460/rbra-wmwv, DOI 10.55460/RBRA-WMWV, 10.55460/RBRA-WMWV]
   Eastridge BJ, 2012, J TRAUMA ACUTE CARE, V73, pS431, DOI 10.1097/TA.0b013e3182755dcc
   Eastridge BJ, 2011, J TRAUMA, V71, pS4, DOI 10.1097/TA.0b013e318221147b
   Mazuchowski EL, 2020, J TRAUMA ACUTE CARE, V88, P686, DOI 10.1097/TA.0000000000002610
NR 6
TC 0
Z9 2
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV-DEC
PY 2025
VL 190
IS 11-12
BP e2620
EP e2623
DI 10.1093/milmed/usae564
EA DEC 2024
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9JP5Y
UT WOS:001383426500001
PM 39722551
DA 2026-07-24
ER
PT J
AU Monami, M
   Scatena, A
   Ragghianti, B
   Miranda, C
   Monge, L
   Silverii, A
   Uccioli, L
   Vermigli, C
AF Monami, Matteo
   Scatena, Alessia
   Ragghianti, Benedetta
   Miranda, Cesare
   Monge, Luca
   Silverii, Antonio
   Uccioli, Luigi
   Vermigli, Cristiana
CA Panel Italian Guidelines Treatment Diabetic Foot Syndrome
   SID AMD
TI Effectiveness of most common adjuvant wound treatments (skin
   substitutes, negative pressure wound therapy, hyperbaric oxygen therapy,
   platelet-rich plasma/fibrin, and growth factors) for the management of
   hard-to-heal diabetic foot ulcers: a meta-analysis of randomized
   controlled trials for the development of the Italian Guidelines for the
   Treatment of Diabetic Foot Syndrome
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Adjuvant therapy; Diabetic foot ulcers; Healing; Meta-analysis;
   Guidelines
ID CONTROLLED CLINICAL-TRIAL; ACELLULAR DERMAL MATRIX; LOWER-EXTREMITY
   ULCERS; DOUBLE-BLIND; MULTICENTER; EFFICACY; PLASMA; SAFETY; AMPUTATION;
   CLOSURE
AB AimTo assess the effects of several adjuvant therapies (AT) commonly used in the treatment of diabetic foot ulcers (DFU). The present meta-analysis was designed to support the development of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome.MethodsA Medline and Embase search were performed up to May 20th, 2024 collecting all RCTs including diabetic patients or reporting subgroup analyses on diabetic patients with DFU comparing AT with placebo/standard of care (SoC), with a duration of at least 12 weeks. Prespecified endpoints were: ulcer healing (principal), time-to-healing, major and minor amputation, serious adverse events (SAE), and all-cause mortality. AT assessed were: growth factors (GF), Platelet-rich plasma and fibrin (PRP/F), skin substitutes (SS), negative pressure wound therapy (NPWT), and hyperbaric oxygen therapy (HBOT). Mantel-Haenzel Odds ratios and 95% confidence intervals (MH-OR, 95% CIs) were either calculated or extracted directly from the publications. Weighted mean differences and 95% CIs were calculated for continuous variables.ResultsFifty-one studies fulfilled all inclusion criteria (3, 5, 27, 8, and 8 with GF, PRP/F, SS, NPWT, and HBOT, respectively). Participants treated with any of the explored AT had a significantly higher ulcer healing rate (MH-OR ranging from 2.17 to 4.18) and shorter time-to-healing in comparison with SoC/placebo. Only PRP/F and HBOT showed a significantly lower risk of major amputation (MH-OR: 0.32(0.11;0,93; p = 0.04 and 0.28(0.10;0,79; p = 0.02, respectively), despite a higher risk of SAE. No other significant effects on the above-reported prespecified endpoints were observed. For the primary endpoint, the quality of evidence was rated as "high" for all the AT, except for NPWT ("moderate").ConclusionsIn conclusion, AT can actively promote wound healing and shorten time-to-healing in patients with DFU. HBOT and PRP/F also showed a reduction of the risk of major amputation, despite a higher rate of SAE.
C1 [Monami, Matteo; Ragghianti, Benedetta; Silverii, Antonio] Azienda Osped Univ Careggi, Florence, Italy.
   [Monami, Matteo; Ragghianti, Benedetta; Silverii, Antonio] Univ Florence, Florence, Italy.
   [Scatena, Alessia] San Donato Hosp, Hlth Author South East Tuscany, Arezzo, Italy.
   [Miranda, Cesare] Pordenone Hosp, Pordenone, Italy.
   [Monge, Luca] AMD Italian Assoc Clin Diabetologists, Rome, Italy.
   [Uccioli, Luigi] Univ Rome, Diabet Sect, CTO Hosp, Rome, Italy.
   [Uccioli, Luigi] Tor Vergata Univ Rome, Dept Biomed & Prevent, Rome, Italy.
   [Scatena, Alessia; Ragghianti, Benedetta; Miranda, Cesare; Monge, Luca; Silverii, Antonio; Uccioli, Luigi; Vermigli, Cristiana] Azienda Sanit Friuli Occidentale, Pordenone, Italy.
   [Scatena, Alessia; Ragghianti, Benedetta; Miranda, Cesare; Monge, Luca; Silverii, Antonio; Uccioli, Luigi; Vermigli, Cristiana] Assoc Volontariato Piede Diabetico Umbria ODV, Perugia, Italy.
   [Vermigli, Cristiana] Univ Hosp Perugia, Perugia, Italy.
   Careggi Teaching Hosp, Diabetic Foot Unit, Florence, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi;
   University of Florence; IRCCS Policlinico San Donato; Sapienza
   University Rome; University of Rome Tor Vergata; University of Florence;
   Azienda Ospedaliero Universitaria Careggi
RP Monami, M (通讯作者)，Azienda Osped Univ Careggi, Florence, Italy.; Monami, M (通讯作者)，Univ Florence, Florence, Italy.
EM matteo.monami@unifi.it
RI Monami, Matteo/L-4074-2019; Monge, Luca/ADD-0944-2022; Miranda,
   Cesare/HPF-1122-2023; uccioli, luigi/AAF-4844-2020; Silverii, Giovanni
   Antonio/ACQ-6013-2022
OI Monge, Luca/0000-0002-0506-1019; Miranda, Cesare/0000-0002-9247-8372;
   Silverii, Giovanni Antonio/0000-0002-6695-3213
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NR 94
TC 7
Z9 7
U1 3
U2 11
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JUL
PY 2025
VL 62
IS 7
BP 1081
EP 1095
DI 10.1007/s00592-024-02426-7
EA DEC 2024
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5FG9Q
UT WOS:001383454900001
PM 39724338
DA 2026-07-24
ER
PT J
AU Nakanishi, R
   Ozawa, H
   Toyota, N
   Akutsu, R
   Fujita, S
AF Nakanishi, Ryo
   Ozawa, Heita
   Toyota, Naoyuki
   Akutsu, Ritsuto
   Fujita, Shin
TI Effectiveness of negative pressure wound therapy (NPWT) in preventing
   incisional surgical site infection after stoma closure: a single
   institutional retrospective study
SO SURGERY TODAY
LA English
DT Article
DE Surgical site infection; NPWT; Stoma closure
ID SKIN CLOSURE; REVERSAL
AB PurposeRecent findings suggest that utilizing negative pressure wound therapy (NPWT) concurrently with stoma closure may decrease the risk of incisional surgical site infection (iSSI). However, the specific impact of NPWT on iSSI after stoma closure remains unclear. This study investigated the impact of NPWT on SSI after stoma closure.MethodsBetween January, 2010 and December, 2022, 185 patients underwent stoma closure at our hospital. Multivariate analysis was conducted to identify the risk factors for iSSI, using logistic regression analysis. Propensity score matching (PSM) was performed to balance the effect of potential co-factors of stoma closure with and without NPWT, on the incidence of superficial SSIs.ResultsMultivariate analysis identified that the absence of NPWT was an independent risk factor for iSSIs (Odds ratio [OR]: 11.1; 95% confidence interval [CI]: 1.88-64.9; P = 0.0078). Following cohort matching, the NPWT-absence and NPWT-presence groups comprised 54 patients each. The incisional SSI rate was significantly lower in the NPWT-presence group than in the NPWT-absence group (0.9%; n = 1 vs. 7.4%; n = 8, respectively; OR: 9.2; 95% CI 1.11-76.4; P = 0.04).ConclusionThe findings of this study demonstrated that stoma closure with NPWT reduced the SSI rates remarkably. Therefore, NPWT should be considered for stoma closure procedures.
C1 [Nakanishi, Ryo; Ozawa, Heita; Toyota, Naoyuki; Akutsu, Ritsuto; Fujita, Shin] Tochigi Canc Ctr, Dept Colorectal Surg, 4-9-13 Yohnan, Utsunomiya, Tochigi 3200834, Japan.
C3 Tochigi Prefectural Cancer Center
RP Nakanishi, R (通讯作者)，Tochigi Canc Ctr, Dept Colorectal Surg, 4-9-13 Yohnan, Utsunomiya, Tochigi 3200834, Japan.
EM one_piece_isoroku@hotmail.co.jp; heiozawa@tochigi-cc.jp;
   naoyuki.toyota@gmail.com; riakutsu@tochigi-cc.jp; sifujita@tochigi-cc.jp
OI Toyota, Naoyuki/0009-0004-0621-4883
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NR 13
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD MAY
PY 2025
VL 55
IS 5
BP 646
EP 651
DI 10.1007/s00595-024-02983-y
EA DEC 2024
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 1RJ9V
UT WOS:001385006400001
PM 39729103
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Shi, WJ
   Zhou, J
   Xu, QL
   Jiang, Y
   Dai, Q
AF Shi, Wen-Juan
   Zhou, Jian
   Xu, Qi-Liang
   Jiang, Yi
   Dai, Qiang
TI Impact of solution-focused brief therapy and vacuum sealing drainage on
   mental health of wound care patients
SO WORLD JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Solution-focused brief therapy; Negative pressure wound therapy;
   Psychological health; Wound healing; Clinical treatment
AB BACKGROUND Improving mental health is crucial for patients who require wound treatment. AIM To analyze the effects of solution-focused brief therapy (SFBT) combined with vacuum sealing drainage on the psychological health of patients undergoing wound treatment, providing a basis for selecting wound treatment protocols. METHODS A total of 102 patients undergoing wound treatment were included, with the study period from March 2020 to March 2024. Sex was not a factor, and patients were randomly assigned to two groups of 51 cases each. The control group received negative pressure wound therapy (NPWT), while the experimental group received NPWT plus SFBT. The recovery of wounds, granulation tissue scores, and psychological health levels were compared between the two groups. Statistical analysis was conducted using SPSS Windows software version 26.0 and GraphPad Prism 8.0. RESULTS Post-treatment, the levels of high-sensitivity C-reactive protein, white blood cell count, and lactate dehydrogenase in the experimental group were significantly lower than those in the control group (P < 0.05). The two groups had no significant difference in granulation tissue scores (P < 0.05). The psychological health level in the experimental group was significantly higher than in the control group (P < 0.05). CONCLUSION The combination of SFBT and NPWT accelerates wound healing, promotes granulation tissue growth, and improves psychological well-being, making it a valuable approach for clinical application.
C1 [Shi, Wen-Juan; Zhou, Jian; Xu, Qi-Liang; Jiang, Yi; Dai, Qiang] Jiangsu Prov Hosp, Dept Burns & Plast Surg, Liyang Branch, 70 Jianshe West Rd, Liyang 213300, Jiangsu, Peoples R China.
C3 Nanjing Medical University
RP Dai, Q (通讯作者)，Jiangsu Prov Hosp, Dept Burns & Plast Surg, Liyang Branch, 70 Jianshe West Rd, Liyang 213300, Jiangsu, Peoples R China.
EM ainimoney@163.com
CR ak AM., 2024, Psychother Res, V1, P13
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NR 15
TC 1
Z9 2
U1 2
U2 5
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2220-3206
J9 WORLD J PSYCHIATR
JI World J. Psychiatr.
PD DEC 19
PY 2024
VL 14
IS 12
DI 10.5498/wjp.v14.i12.1854
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA Q6R8R
UT WOS:001385934400003
PM 39704379
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Monsch, GM
   Etienne, H
   Hillinger, S
   Caviezel, C
   Lauk, O
   Opitz, I
   Schneiter, D
AF Monsch, Gian-Marco
   Etienne, Harry
   Hillinger, Sven
   Caviezel, Claudio
   Lauk, Olivia
   Opitz, Isabelle
   Schneiter, Didier
TI Accelerated treatment concept in postpneumonectomy empyema with
   bronchopleural fistula
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Postpneumonectomy empyema; Bronchopleural fistula; Accelerated treatment
   concept (Zurich concept)
ID SURGICAL-MANAGEMENT; RISK-FACTORS; LUNG-CANCER; PNEUMONECTOMY;
   DEBRIDEMENT; PREVENTION; SPACE
AB Treatment of postpneumonectomy empyema remains challenging, especially in presence of bronchopleural fistula. We analysed clinical outcome data of patients with and without bronchopleural fistula undergoing an accelerated empyema treatment concept. From November 2005 to July 2020, all patients with postpneumonectomy empyema were included. Therapy consisted of repeated surgical debridement of the pleural cavity, evaluation for loco-regional flap, negative pressure wound therapy and definitive closure after installation an antibiotic solution in the cavity. Primary endpoint was perioperative mortality, focusing on comparison between patients with (= group A) and without bronchopleural fistula (= group B). Secondary endpoints were empyema resolution/recurrence and length of stay. 58 patients underwent the treatment concept: 19 (32.8%) with bronchopleural fistula. Patients' mean age was 62.7 +/- 11.5 years. Nine patients (15.5%) deceased within 30 days: 3 (15.8%) in group A, 6 (15.4%) in group B. 90-days mortality tends to be lower in group A (n = 3 (15.8%)) compared to group B (n = 11 (28.2%)) (p = 0.078). Incidence of postoperative complication was 63.2% (n = 12) in group A compared to 56.4% (n = 22) in group B (p = 0.316). Postpneumonectomy empyema resolution was 100% in the cohort. 3 patients (15.8%) in the group A and 3 (7.7%) in group B (p = 0.175) developed an empyema-recurrence, successfully managed with the treatment concept again. Mean hospital length of stay was lower in group A (24.6 +/- 9.5 days vs 27.2 +/- 24.3 days in group B; p = 0.329). With our accelerated treatment concept, postpneumonectomy empyema with bronchopleural fistula could effectively and safely be treated while maintaining integrity of the chest wall.Clinical Registration Number: KEK-ZH-NR: 2021-01114.
C1 [Monsch, Gian-Marco; Etienne, Harry; Hillinger, Sven; Caviezel, Claudio; Lauk, Olivia; Opitz, Isabelle; Schneiter, Didier] Univ Hosp Zurich, Dept Thorac Surg, Raemistr 100, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Schneiter, D (通讯作者)，Univ Hosp Zurich, Dept Thorac Surg, Raemistr 100, CH-8091 Zurich, Switzerland.
EM didier.schneiter@usz.ch
CR Abou Dagher G, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-013502
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NR 29
TC 2
Z9 2
U1 1
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 30
PY 2024
VL 14
IS 1
AR 31837
DI 10.1038/s41598-024-83334-2
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Q7I6J
UT WOS:001386372100044
PM 39738609
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Selçuk, E
   Erem, M
   Yildirim, S
   Çopuroglu, C
   Çiftdemir, M
   Erkal, D
AF Selcuk, Esref
   Erem, Murat
   Yildirim, Savas
   Copuroglu, Cem
   Ciftdemir, Mert
   Erkal, Dogukan
TI Risk factors and rates of revision amputation following ischemic lower
   major limb amputations: A 10-year retrospective analysis
SO JOINT DISEASES AND RELATED SURGERY
LA English
DT Article
DE Amputation; chronic limb threatening ischemia; reoperation; risk
   factors; peripheral arterial disease
ID PERIPHERAL ARTERY-DISEASE; MORTALITY; THERAPY
AB Objectives: This study aimed to evaluate the rates and risk factors associated with revision amputation following ischemic lower major limb amputations, focusing on cases related to peripheral arterial disease. Patients and methods: This retrospective study included 253 patients (174 males, 79 females; mean age: 73.1 +/- 12.2 years; range, 44 to 99 years) who underwent ischemic foot amputation between December 2012 and December 2022. Eligible patients were over 18 years old and had major lower extremity amputations due to peripheral arterial disease or chronic arterial occlusion. Exclusions were made for amputations due to diabetic foot conditions, trauma, tumors, or osteomyelitis and minor lower extremity amputations. Results: Above-knee amputations were the most common type of amputation, accounting for 56.5% (n=143) of cases. Revision amputations occurred in 27.3% (n=69) of patients, with significantly higher rates in those with open wounds at first admission (chi-square [chi(2) ]=9.81, p=0.002). Patients with occlusion at the popliteal artery level had a higher rate of revision amputation following below-knee amputation (p=0.034). Each additional year of age decreased the likelihood of revision amputation by 2.3% (p=0.049). Vacuum-assisted closure therapy was associated with higher revision rates (chi(2) =22.71, p<0.001). Patients who developed infections (n=40) had a significantly higher rate of revision amputations (n=26, p<0.001). Elevated preoperative C-reactive protein levels were also correlated with an increased risk of revision (p=0.006). Conclusion: Patients with ischemic lower limb amputations, particularly those presenting with open wounds, are at higher risk for revision amputation. Elevated preoperative C-reactive protein levels, infections, age, and the initial level of amputation significantly impact the likelihood of reamputation.
C1 [Selcuk, Esref; Erem, Murat; Yildirim, Savas; Copuroglu, Cem; Ciftdemir, Mert; Erkal, Dogukan] Trakya Univ, Fac Med, Dept Orthoped & Traumatol, Edirne, Turkiye.
C3 Trakya University
RP Selçuk, E (通讯作者)，Trakya Univ, Tip Fak, Ortoped & Travmatol Anabilim Dali, TR-22030 Edirne, Turkiye.
EM trkesref@hotmail.com
RI yıldırım, savaş/ACV-1803-2022; selçuk, eşref/HDM-6006-2022; Erem,
   Murat/P-6240-2018
OI yıldırım, savaş/0000-0003-0677-4720; Çiftdemir,
   Mert/0000-0002-9677-2819; selçuk, eşref/0000-0002-1657-1110; Erem,
   Murat/0000-0002-9743-5515; Erkal, Doğukan/0000-0001-7390-5781
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   Wilkin G, 2014, J BONE JOINT SURG AM, V96A, P1378, DOI 10.2106/JBJS.M.01010
NR 21
TC 5
Z9 5
U1 0
U2 4
PU TURKISH JOINT DISEASES FOUNDATION
PI CANKAYA
PA MUSTAFA KEMAL MAHALLESI, DUMLUPINAR BULVARI 274-2 C2 BLOK OFIS, 5,
   CANKAYA, ANKARA, Turkiye
EI 2687-4792
J9 JOINT DIS RELAT SURG
JI Joint Dis. Relat. Surg.
PY 2025
VL 36
IS 1
BP 174
EP 181
DI 10.52312/jdrs.2025.203
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA Q9N5Y
UT WOS:001387855200021
PM 39719915
DA 2026-07-24
ER
PT J
AU Kolek, M
   Duricová, J
   Brozmanová, H
   Sistík, P
   Jurica, J
   Kanková, K
   Motyka, O
   Kacírová, I
AF Kolek, Martin
   Duricova, Jana
   Brozmanova, Hana
   Sistik, Pavel
   Jurica, Jan
   Kankova, Klara
   Motyka, Oldrich
   Kacirova, Ivana
TI Vancomycin wound penetration in open-heart surgery patients receiving
   negative pressure wound therapy for deep sternal wound infection
SO ANNALS OF MEDICINE
LA English
DT Article
DE Deep sternal wound infection; exudate; negative pressure wound therapy;
   open-heart surgery; vancomycin; wound penetration
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; RISK-FACTORS; MEDIASTINITIS;
   MICROBIOLOGY; MANAGEMENT; IMPACT
AB Introduction
   It is hypothesized that systemically administered antibiotics penetrate wound sites more effectively during negative pressure wound therapy (NPWT). However, there is a lack of clinical data from patients who receive NPWT for deep sternal wound infection (DSWI) after open-heart surgery. Here, we evaluated vancomycin penetration into exudate in this patient group.
   Patients and methods
   For this prospective observational study, we enrolled 10 consecutive patients treated with NPWT for post-sternotomy DSWI. On the first sampling day, serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3 and 6 h after vancomycin administration. On the following three consecutive days, additional samples were collected, only before vancomycin administration.
   Results
   The ratio of average vancomycin concentration in wound exudate to in serum was higher for free (unbound) (1.51 +/- 0.53) than for total (bound + unbound) (0.91 +/- 0.29) concentration (p = 0.049). The percentage of free vancomycin was higher in wound exudate than serum (0.79 +/- 0.19 vs. 0.46 +/- 0.16; p = 0.04). Good vancomycin wound penetration was maintained on the following three days (vancomycin trough exudate-to-serum concentration ratio > 1). The total hospital stay was significantly longer in patients with DSWI (46 +/- 11.6 days) versus without DSWI (14 +/- 11.7 days) (p < 0.001). There was no in-hospital or 90-day mortality. Two patients experienced late DSWI recurrence. All-cause mortality was 4.8% during a median follow-up of 2.5 years.
   Conclusion
   Vancomycin effectively penetrates wound exudate in patients receiving NPWT for DSWI after open-heart surgery.
C1 [Kolek, Martin; Kankova, Klara] Univ Hosp Ostrava, Dept Cardiac Surg, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.
   [Kolek, Martin] Univ Ostrava, Fac Med, Dept Clin Subjects, Ostrava, Czech Republic.
   [Duricova, Jana; Brozmanova, Hana; Sistik, Pavel; Kacirova, Ivana] Univ Hosp Ostrava, Inst Lab Med, Dept Clin Pharmacol, Ostrava, Czech Republic.
   [Duricova, Jana; Brozmanova, Hana; Sistik, Pavel; Kacirova, Ivana] Univ Ostrava, Fac Med, Dept Clin Pharmacol, Ostrava, Czech Republic.
   [Jurica, Jan] Masaryk Univ, Fac Med, Dept Pharmacol, Brno, Czech Republic.
   [Jurica, Jan] Masaryk Mem Canc Inst, Hosp Pharm, Brno, Czech Republic.
   [Motyka, Oldrich] VSB Tech Univ Ostrava, Fac Min & Geol, Dept Environm Engn, Ostrava, Czech Republic.
C3 University Hospital Ostrava; University of Ostrava; University Hospital
   Ostrava; University of Ostrava; Masaryk University; Masaryk Memorial
   Cancer Institute; Technical University of Ostrava
RP Kolek, M (通讯作者)，Univ Hosp Ostrava, Dept Cardiac Surg, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.
EM martin.kolek@fno.cz
RI Kacirova, Ivana/I-4241-2016; Kolek, Martin/D-4115-2018; Motyka,
   Oldřich/AAF-1313-2020; Jurica, Jan/ABE-1694-2021; Brozmanova,
   ./G-9793-2019
OI Kacirova, Ivana/0000-0001-6618-754X; Kolek, Martin/0000-0002-0418-3006;
   Motyka, Oldřich/0000-0002-9644-0611; Jurica, Jan/0000-0002-0257-6711; 
FU Ministry of health, czech Republic - conceptual development of research
   organization (FNOs/2021)
FX this work was supported by the Ministry of health, czech Republic -
   conceptual development of research organization (FNOs/2021).
CR [Anonymous], 2024, R: a language and environment for statistical computing
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NR 29
TC 1
Z9 2
U1 2
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD DEC 31
PY 2025
VL 57
IS 1
AR 2444544
DI 10.1080/07853890.2024.2444544
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q9Q8U
UT WOS:001387940600001
PM 39711425
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jin, YL
   Zhu, T
   Cai, X
   Fu, Z
   Pan, QL
   Tu, HX
   Wang, SX
   Li, Y
AF Jin, Yuanling
   Zhu, Tao
   Cai, Xiao
   Fu, Zheng
   Pan, Qianglong
   Tu, Haixia
   Wang, Shouxing
   Li, Yan
TI Identification and treatment of Enterococcus avium-induced
   diabetic foot ulcer: a case report and microbiome analysis
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE diabetic foot ulcers; E. avium; microbiome analysis; second-generation
   sequencing technology; minimal inhibit concentration
ID RISK-FACTORS; INFECTION; DISEASE
AB Diabetic foot ulcer (DFU) is a severe complication of diabetes. Due to conservative or delayed treatment, the majority of DFU patients frequently miss the optimal treatment window, thereby leading to amputation. Despite being a rare pathogen with low virulence, Enterococcus avium (E. avium) exhibits some antibiotic resistance and can be fatal for immunocompromised patients. This report describes a DFU case, caused by E. avium infection due to exposure to poultry. Wound microbiota was dynamically monitored using bacterial culture followed by 16S rRNA gene sequencing throughout the illness. Combination of antibiotics was administered to control the secondary infection.
   Case report: A 56-year-old man presented with a two-week history of redness, swelling, heat, pain, and pus discharge from a ruptured wound on his left heel. The patient was diagnosed with osteomyelitis and a Wagner grade 3 diabetic foot ulcer infection, complicated by the soft tissue infection in the left heel. Strain identification and antibiotic susceptibility tests were immediately performed after admission. The patient underwent three debridement procedures at the DFU site. However, we observed recurrent bacterial infections, based on the clinical progression. Second-generation sequencing detected various pathogens. After targeted treatment with Vacuum sealing drainage (VSD) combined with antibiotic bone cement, the patient's condition stabilised. A skin graft was subsequently performed. Antibiotics were used to control the infection and blood glucose level was controlled throughout the treatment.
   Conclusion: Thus, this report provides a comprehensive description of a DFU case, caused by E. avium. Antibiotics and surgical measures should be adjusted according to the pathogens responsible for wound infections in DFU patients. It is important to reduce the mortality and prevent irreversible amputations.
C1 [Jin, Yuanling; Zhu, Tao; Cai, Xiao; Pan, Qianglong; Tu, Haixia; Wang, Shouxing; Li, Yan] Nanjing Med Univ, Sir Run Run Hosp, Dept Clin Lab, Nanjing, Peoples R China.
   [Fu, Zheng] Nanjing Med Univ, Sir Run Run Hosp, Dept Hand Surg, Nanjing, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University
RP Wang, SX; Li, Y (通讯作者)，Nanjing Med Univ, Sir Run Run Hosp, Dept Clin Lab, Nanjing, Peoples R China.
EM wshx1120@126.com; yanli@njmu.edu.cn
RI tu, haixia/NEC-1248-2025; Fu, Zheng/LTF-9857-2024
FU National Natural Science Foundation of China, Sir Run Run hospital, and
   Nanjing Medical University
FX We thank the staff of the clinical microbiology laboratory at Sir Run
   Run hospital, Nanjing Medical University for help with initial isolation
   and characterization of the isolate.
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NR 50
TC 1
Z9 2
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD DEC 20
PY 2024
VL 11
AR 1502337
DI 10.3389/fmed.2024.1502337
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA R0O5L
UT WOS:001388555900001
PM 39760042
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kim, Y
   Cui, CL
   Shafique, HS
   Weissler, EH
   Johnson, AP
   Coleman, DM
   Southerland, KW
AF Kim, Young
   Cui, Christina L.
   Shafique, Hana S.
   Weissler, E. Hope
   Johnson, Adam P.
   Coleman, Dawn M.
   Southerland, Kevin W.
TI Effectiveness of Negative Pressure Wound Therapy on Groin Surgical Site
   Infection After Lower Extremity Bypass for Chronic Limb-Threatening
   Ischemia
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; VASCULAR-SURGERY; REVASCULARIZATION;
   COMPLICATIONS; EPIDEMIOLOGY; PREDICTORS; REDUCTION; DISEASE; TRIAL;
   CINPT
AB Background: Surgical site infections (SSIs) are a common cause of patient morbidity, hospital readmission, and reoperation after lower extremity bypass (LEBs) surgery for chronic limbthreatening ischemia (CLTI). Recent studies on the use of incisional negative pressure wound therapy (NPWT) in LEB surgery have reported conflicting results. In this single-center study, we examined our experience on the impact of NPWT on groin SSI rates after LEB surgery.<br /> Methods: We retrospectively queried electronic medical records for all LEB operations performed for CLTI. Multivariate logistic regression analysis was used to identify risk factors associated with postoperative SSI. Using these risk factors, subset analysis was performed to determine whether NPWT was associated with reduced SSI in high-risk patients.<br /> Results: From 2018 to 2022, a total of 367 patients underwent LEB surgery for CLTI. Mean patient age was 66 years. Postoperative groin SSI was diagnosed in 22.9% (n - 84) of patients. Patients suffering SSI were more frequently morbidly obese (6.0% vs 1.8%, P - 0.03) and had higher rates of chronic obstructive pulmonary disease (35.7% vs 23.3%, P - 0.02). Other comorbidities and demographic data were similar between groups. NPWT was utilized in 19.6% (n - 72) of patients, with no baseline differences between SSI and no SSI cohorts (15.5% vs 20.9%, P - 0.28). On multivariate analysis, female sex (odds ratio [OR] 1.88, 95% confidence interval [CI] 1.06-3.35, P - 0.03), white race (OR 2.17, 95% CI 1.23-3.82, P - 0.007), morbid obesity (OR 3.67, 95% CI 0.93-14.4, P - 0.05), and active smoking (OR 4.07, 95% CI 1.20-13.8, P - 0.02) were independently associated with postoperative SSI. Subset analysis among patients at increased risk of SSI did not reveal any differences in wound infection with NPWT usage.<br /> Conclusions: In our experience, NPWT does not appear to be more effective than standard dressings in preventing groin SSI after LEB surgery for CLTI, even among populations at heightened risk for wound infection.
C1 [Kim, Young; Cui, Christina L.; Shafique, Hana S.; Weissler, E. Hope; Johnson, Adam P.; Coleman, Dawn M.; Southerland, Kevin W.] Duke Univ, Div Vasc & Endovasc Surg, Durham, NC USA.
C3 Duke University
RP Kim, Y (通讯作者)，Duke Univ, Med Ctr, Div Vasc & Endovasc Surg, 2301 Erwin Rd, Durham, NC 27708 USA.
EM y.kim@duke.edu
OI Johnson, Adam/0000-0002-3014-6372; Kim, Young/0000-0001-8763-8813;
   Coleman, Dawn/0000-0001-5622-7253
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   Svensson-Björk R, 2021, J TISSUE VIABILITY, V30, P95, DOI 10.1016/j.jtv.2020.09.005
   Tulimieri MT, 2024, ANN VASC SURG, V102, P47, DOI 10.1016/j.avsg.2023.11.050
   van Dam MA, 2022, ANN VASC SURG, V78, P93, DOI 10.1016/j.avsg.2021.06.035
   van de Weijer MAJ, 2015, SEMIN VASC SURG, V28, P112, DOI 10.1053/j.semvascsurg.2015.09.004
   Vogel TR, 2010, J VASC SURG, V51, P122, DOI 10.1016/j.jvs.2009.08.006
   Yost M.L, 2023, Vasc Dis Manag, V20, P67
   Yuan S, 2023, INT WOUND J, V20, P2334, DOI 10.1111/iwj.14043
NR 45
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD FEB
PY 2025
VL 111
BP 143
EP 150
DI 10.1016/j.avsg.2024.10.020
EA DEC 2024
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA R1B0P
UT WOS:001388881300001
PM 39581325
DA 2026-07-24
ER
PT J
AU Tulimieri, MT
   Callas, PW
   Bertges, DJ
AF Tulimieri, Maxwell T.
   Callas, Peter W.
   Bertges, Daniel J.
TI Effectiveness of Closed Incision Negative Pressure Wound Therapy for
   Suprainguinal Bypass in the Vascular Quality Initiative
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID OUTCOMES
AB Background: We sought to explore the utility of closed incision negative pressure wound therapy (ciNPWT) in prevention of groin wound complications after suprainguinal bypass using a national quality improvement database reflective of real-world practice. Methods: The Vascular Quality Initiative was queried for suprainguinal bypass procedures from December 2019 to August 2023. Propensity matching was performed comparing ciNPWT versus standard dressings at (1) the index hospitalization (full cohort) and (2) 30 days (subgroup). The primary outcome was surgical site infection (SSI) at 30 days. Secondary outcomes included in-hospital SSI, return to operating room for infection, discharge disposition, length of stay and 30-day readmission rate, noninfectious wound complications, and mortality. Results: The propensity-matched cohort consisted of 3,467 of a total of 5,082 patients undergoing suprainguinal bypass. Within the propensity-matched full cohort, 2,680 (77%) received standard dressing and 787 (23%) ciNPWT. Of those, 337 (61%) in the standard group and 150 (31%) in the ciNPWT group had 30-day follow-up data. There was a significant decrease in the rates of in-hospital SSI for those with ciNPWT at 2% compared to those with standard dressing at 4% (P - 0.02). There was no difference in 30-day SSI between groups with 3% in the ciNPWT group and 4% in the standard group (P - 0.40). After adjusting, there was no differences in 30-day readmission rates (P - 0.37), 30-day noninfectious wound complications (P - 0.28), 30-day mortality (P - 0.24), discharge disposition (P - 0.82), or length of stay (P Conclusions: In this Vascular Quality Initiative analysis of suprainguinal bypass, we observed a decrease in the in-hospital SSI rate but no difference in the SSI or noninfectious wound complications at 30 days for patients treated with ciNPWT versus standard dressings. Given these findings, consideration should be given to conducting an adequately powered randomized control trial of ciNPWT targeted for suprainguinal bypass.
C1 [Tulimieri, Maxwell T.] Michigan State Univ, Spectrum Hlth Meijer Heart Ctr, Dept Vasc Surg, Grand Rapids, MI USA.
   [Callas, Peter W.] Univ Vermont, Med BioStat, Burlington, VT 05401 USA.
   [Bertges, Daniel J.] Univ Vermont, Med Ctr, Div Vasc Surg & Endovasc Therapy, Burlington, VT 05401 USA.
C3 Michigan State University; University of Vermont; University of Vermont
   Medical Center; University of Vermont
RP Bertges, DJ (通讯作者)，Univ Vermont, Med Ctr, Div Vasc Surg, Surg & Med, 111 Colchester Ave,Smith 338, Burlington, VT 05401 USA.
EM daniel.bertges@uvmhealth.org
CR Austin PC, 2011, MULTIVAR BEHAV RES, V46, P399, DOI 10.1080/00273171.2011.568786
   Bertges DJ, 2016, J VASC SURG, V64, P1411, DOI 10.1016/j.jvs.2016.04.045
   Diamond KR, 2019, J VASC SURG, V69, P1831, DOI 10.1016/j.jvs.2018.08.195
   Gombert A, 2018, EUR J VASC ENDOVASC, V56, P442, DOI 10.1016/j.ejvs.2018.05.018
   Gwilym BL, 2021, EUR J VASC ENDOVASC, V61, P636, DOI 10.1016/j.ejvs.2020.11.053
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   Saadeddin ZM, 2019, EUR J VASC ENDOVASC, V58, P529, DOI 10.1016/j.ejvs.2019.02.010
   Scali ST, 2021, J VASC SURG, V73, P1031, DOI 10.1016/j.jvs.2020.06.119
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   Strobel RM, 2022, LANGENBECK ARCH SURG, V407, P819, DOI 10.1007/s00423-021-02346-y
   Tulimieri MT, 2024, ANN VASC SURG, V102, P47, DOI 10.1016/j.avsg.2023.11.050
   vqi, 2024, About us
   Wee IJY, 2019, EUR J VASC ENDOVASC, V58, P446, DOI 10.1016/j.ejvs.2018.12.021
NR 19
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD FEB
PY 2025
VL 111
BP 241
EP 249
DI 10.1016/j.avsg.2024.11.008
EA DEC 2024
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA R1U5T
UT WOS:001389388700001
PM 39581317
DA 2026-07-24
ER
PT J
AU Yang, LH
   Kong, J
   Xing, YL
   Pan, LF
   Li, CH
   Wu, ZX
   Li, MX
   Zhang, LB
AF Yang, Liehao
   Kong, Jiao
   Xing, Yunlong
   Pan, Lingfeng
   Li, Caihong
   Wu, Zhuoxia
   Li, Mingxi
   Zhang, Lianbo
TI Adjunctive hyperbaric oxygen therapy and negative pressure wound therapy
   for hard-to-heal wounds: a systematic review and meta-analysis
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE chronic wounds; hyperbaric oxygen therapy; meta-analysis; negative
   pressure wound therapy; systematic review; wound; wound care; wound
   dressing; wound healing
ID MANAGEMENT; CARE
AB Objective: Negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBOT) have been widely used in the treatment of hard- to-heal (chronic) wounds, but there is still a lack of sufficient evidence for their combined use for the treatment of hard-to-heal wounds. This systematic review aimed to identify the clinical efficacy and safety of adding adjunctive HBOT to NPWT for hard-to-heal wounds.<br /> Method: Embase, PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure and Wanfang were searched from the establishment of the database to March 2022. The literature was screened according to the inclusion criteria and exclusion criteria. We assessed the quality of each included study with the Cochrane Collaboration Risk of Bias tool and Newcastle-Ottawa Scale. A meta- analysis was performed using R programming software version 4.1.0 (R Project for Statistical Computing, US). The PRISMA 2020 guidelines were used to report data from systematic reviews and meta-analysis.<br /> Results: A total of 15 studies were identified, including nine randomised clinical controlled trials and six retrospective studies. Meta-analysis results showed that NPWT combined with HBOT had better outcomes compared with the NPWT alone with regards to: wound healing rate (odds ratio (OR)=6.77; 95% confidence interval (Cl): 3.53-12.98; p<0.0001); bacterial positive rate of wound (OR=0.16; 95% CI: 0.05-0.55; p=0.0037); wound healing time (mean difference (MD)= -3.86; 95% Cl: -5.18--2.53; p<0.0001); wound area (standardised mean difference (SMD)=1.50; 95% Cl: 0.35-2.65; p=0.0104); hospitalisation time (MD= - 3.14; 95% Cl: - 4.93- - 1.36; p=0.005); and hospitalisation cost (OR=-202.64; 95% Cl: -404.53--0.75; p=0.0492). There was no significant difference in pain score (MD= -0.43; 95% Cl: -1.15-0.30; p=0.25).<br /> Conclusion: The findings of this study demonstrated that adjunctive HBOT with NPWT is safe and effective in the treatment of hard-to- heal wounds. However, these findings should be interpreted with great caution given the limitations of the studies included.
C1 [Yang, Liehao; Kong, Jiao; Xing, Yunlong; Pan, Lingfeng; Li, Caihong; Wu, Zhuoxia; Li, Mingxi; Zhang, Lianbo] Jilin Univ, Dept Plast Surg, China Japan Union Hosp, Changchun, Peoples R China.
C3 Jilin University
RP Zhang, LB (通讯作者)，Jilin Univ, Dept Plast Surg, China Japan Union Hosp, Changchun, Peoples R China.
EM lianbo@jlu.edu.cn
RI Pan, Lingfeng/QQB-1441-2026
OI Li, Caihong/0009-0000-3728-6864; Yang, Liehao/0009-0009-4939-7292; Pan,
   Lingfeng/0009-0004-5846-3216
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   Powers JG, 2016, J AM ACAD DERMATOL, V74, P607, DOI 10.1016/j.jaad.2015.08.070
   Qin HY, 2018, Health Required, P261
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NR 39
TC 5
Z9 7
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2024
VL 33
IS 12
BP 950
EP 957
DI 10.12968/jowc.2022.0213
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA R3Y9B
UT WOS:001390854500010
PM 39630554
DA 2026-07-24
ER
PT J
AU Keum, H
   Zhivov, EV
   Ortega-Loayza, AG
AF Keum, Heejo
   Zhivov, Elina V.
   Ortega-Loayza, Alex G.
TI Updates in innovation of the treatment of pyoderma gangrenosum
SO EXPERT REVIEW OF CLINICAL PHARMACOLOGY
LA English
DT Review
DE Pyoderma gangrenosum; treatment; wound care; pain management;
   spesolimab; vilobelimab; janus kinase inhibitor; negative pressure wound
   therapy
ID THERAPY
AB IntroductionPyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by rapidly enlarging, painful ulcers with undermined borders. The management of PG is challenging due to the lack of standardized evidence-based treatments.Areas coveredThis review examines recent efforts to establish standardized outcomes for clinical trials to facilitate the drug development process for PG. It explores new therapeutics in development and evaluates advanced options for wound and pain management. Literature available on the pathogenesis, treatment, and pain management of PG from database inception to April 2024 was searched in PubMed, Embase, and Cochrane. ClinicalTrials.gov and the EU Clinical Trials Register were searched for clinical trials on PG.Expert opinionNew therapeutics such as interleukin 36 inhibitor and complement component C5a inhibitor more specifically target key pathways in the pathogenesis of PG have shown promise and can greatly benefit patients with PG, which still lacks an FDA-approved treatment. In addition to systemic therapy, local wound care and pain management should be carried out simultaneously to achieve successful wound healing.
C1 [Keum, Heejo] Univ Texas Southwestern Med Ctr, Dept Internal Med, Dallas, TX USA.
   [Zhivov, Elina V.] Univ Miami, Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL USA.
   [Ortega-Loayza, Alex G.] Oregon Hlth & Sci Univ, Dept Dermatol, 3303 SW Bond Ave CH 16D, Portland, OR 97239 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Miami; Oregon Health & Science University
RP Ortega-Loayza, AG (通讯作者)，Oregon Hlth & Sci Univ, Dept Dermatol, 3303 SW Bond Ave CH 16D, Portland, OR 97239 USA.
EM oretegalo@ohsu.edu
RI Loayza, Alex/AAN-3319-2020
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NR 58
TC 5
Z9 5
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1751-2433
EI 1751-2441
J9 EXPERT REV CLIN PHAR
JI Expert Rev. Clin. Pharmacol.
PD FEB 1
PY 2025
VL 18
IS 1-2
BP 29
EP 39
DI 10.1080/17512433.2024.2447776
EA JAN 2025
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA X1W3W
UT WOS:001391137600001
PM 39720859
DA 2026-07-24
ER
PT J
AU Molska, M
   Wojciech, M
   Murawa, D
AF Molska, Maja
   Wojciech, Magdalena
   Murawa, Dawid
TI Comparison of Single-Use Negative-Pressure Wound Therapy (sNPWT) and
   Standard Dressings Applied to the Same Patient During Bilateral Tissue
   Expander-to-Implant Exchanges
SO CANCERS
LA English
DT Article
DE breast cancer; breast reconstruction; wound healing; sNPWT; scar
ID BREAST RECONSTRUCTION; MASTECTOMY RATES; INCISION; SURGERY
AB Background: Breast cancer is the most common cancer among women. The number of cases is increasing among young women, and consequently, breast reconstructions are performed more often. Postoperative complications, wound healing, and the quality of scars influence the final cosmetic outcomes. The aim of the study was to investigate the effect of using a negative-pressure therapy compared to a standard dressing on two postoperative wounds in the same woman, after bilateral tissue expander replacement surgery-when identical healing conditions occur. Methods: This study includes a single-center evaluation of the application of two different dressings during bilateral exchanges of tissue expanders with breast implants. The study included 22 patients with a history of breast cancer after bilateral mastectomy with two-stage reconstruction. During the second stage, a sNPWT was applied to one breast and a standard dressing to the other. Results: A statistically significant difference in skin elasticity in favor of sNPWT was visible after 7 days, while the greatest difference was visible in the evaluation after 6 months (mean of 0.806 vs. 0.607). A difference in temperature measurements was shown 7 days after the procedure. However, after 30 days, these measurements were similar. There was also a reduced incidence of postoperative complications as well as seroma accumulation in the breasts with negative pressure. Conclusions: The results indicate faster healing, better scar quality, and improved skin elasticity in breasts with sNPWT compared to the standard dressing. The number of postoperative complications were also reduced, which is especially important in high-risk patients.
C1 [Molska, Maja; Murawa, Dawid] Univ Hosp Zielona Gora, Clin Dept Gen & Oncol Surg, PL-65046 Zielona Gora, Poland.
   [Molska, Maja; Murawa, Dawid] Univ Zielona Gora, Coll Med, Dept Surg & Oncol, PL-65046 Zielona Gora, Poland.
   [Wojciech, Magdalena] Univ Zielona Gora, Inst Math, PL-65417 Zielona Gora, Poland.
C3 University of Zielona Gora; University of Zielona Gora
RP Molska, M (通讯作者)，Univ Hosp Zielona Gora, Clin Dept Gen & Oncol Surg, PL-65046 Zielona Gora, Poland.; Molska, M (通讯作者)，Univ Zielona Gora, Coll Med, Dept Surg & Oncol, PL-65046 Zielona Gora, Poland.
EM majaa.molska@gmail.com
RI ; Wojciech, Magda/ABB-5969-2021
OI , Maja Molska/0009-0005-4802-7979; Murawa, Dawid/0000-0003-3156-1882; 
CR Angarita AM, 2022, AM J OBST GYNEC MFM, V4, DOI 10.1016/j.ajogmf.2022.100617
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NR 32
TC 2
Z9 2
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JAN
PY 2025
VL 17
IS 1
AR 3
DI 10.3390/cancers17010003
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA R7S9M
UT WOS:001393412200001
PM 39796634
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jin, CH
   Tian, ZH
AF Jin, Changhui
   Tian, Zonghua
TI Psychological stress level surveys in patients with diabetic foot ulcers
   and the application effect of using loofah sponges during VSD treatment
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Diabetic foot ulcer; psychological stress; loofah fiber; VSD treatment;
   nursing interventions
ID PRESSURE WOUND THERAPY
AB Objective: To investigate the psychological stress levels in patients with diabetic foot ulcer (DFU) and evaluate the effects of using a luffa sponge in vacuum sealing drainage (VSD) treatment. Methods: This retrospective study analyzed the clinical data from 110 DFU patients treated with VSD at The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University) between September 2021 and October 2023. Patients were categorized into two groups based on psychological stress levels: an observation group (with psychological stress, n=42) and a control group (without psychological stress, n=68). Baseline data were analyzed to identify factors influencing psychological stress. The observation group was further divided into the conventional care group and the loofah fiber care group, each with 21 patients, to evaluate the effect of using a loofah sponge during VSD treatment. Results: Logistic regression analysis identified Wagner classification and diabetes-related distress levels as significant factors influencing psychological stress (P<0.05). Post-intervention, the loofah fiber care group showed significantly lower scores on HQ-9, GAD-7, and SRSS (all P<0.05). Additionally, the loofah fiber care group showed lower frequencies of ASD dressing changes, shorter wound healingtimes, shorter hospital stays, and lower VAS pain scores (all P<0.05). Quality of life scores were significantly higher in the loofah fiber care group across all dimensions (P<0.05), and DASS-21 scores were significantly lower post-intervention (P<0.05). The loofah fiber care group also demonstrated significantly better outcomes in Wagner classification and diabetes-related distress levels, with higher patient satisfaction (all P<0.05). Conclusion: This study highlights significant factors influencing psychological stress in patients with DFU and demonstrates that loofah fiber nursing interventions during VSD treatment improve psychological stress, wound healing, and quality of life. This method provides a promising approach to enhance patient outcomes and satisfaction.
C1 [Jin, Changhui] Zunyi Med Univ, Peoples Hosp Zunyi 1, Affiliated Hosp 3, Operat Room, Zunyi 563000, Guizhou, Peoples R China.
   [Tian, Zonghua] Zunyi Med Univ, Peoples Hosp Zunyi 1, Affiliated Hosp 3, Burn Plast Surg, 98 Fenghuang North Rd, Zunyi 563000, Guizhou, Peoples R China.
C3 Zunyi Medical University; Zunyi Medical University
RP Tian, ZH (通讯作者)，Zunyi Med Univ, Peoples Hosp Zunyi 1, Affiliated Hosp 3, Burn Plast Surg, 98 Fenghuang North Rd, Zunyi 563000, Guizhou, Peoples R China.
EM tzh18685283928@163.com
FU Natural Science Foundation of Zunyi Science and Technology Department
   [Zunyi Kehe HZ Zi (2019) 158Hao]
FX This work was supported by the Natural Science Foundation of Zunyi
   Science and Technology Department (Zunyi Kehe HZ Zi (2019) 158Hao) .
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NR 28
TC 1
Z9 1
U1 0
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2024
VL 16
IS 12
BP 8032
EP 8042
DI 10.62347/LCRY8746
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA R8S6G
UT WOS:001394079800005
PM 39822498
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Rajabaleyan, P
   Vang, A
   Möller, S
   Khalaf, S
   Ladegaard, AG
   Qvist, N
   Ellebaek, MB
AF Rajabaleyan, Pooya
   Vang, Ask
   Moller, Soren
   Khalaf, Sardar
   Ladegaard, Anna Gosvig
   Qvist, Niels
   Ellebaek, Mark Bremholm
TI Vacuum-Assisted Closure Significantly Reduces Surgical Postoperative
   Complications Compared With Primary Abdominal Closure in Patients With
   Secondary Peritonitis: A Comparative Retrospective Study
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
DE open abdomen; secondary peritonitis; vacuum-assisted closure
ID PRESSURE WOUND THERAPY; OPEN ABDOMEN; NEGATIVE-PRESSURE; DAMAGE CONTROL;
   PLANNED RELAPAROTOMY; SEPSIS; MANAGEMENT; TRAUMA; SURGERY; LAPAROSTOMY
AB Background: Vacuum-assisted abdominal closure (VAC) is being increasingly used as an adjunctive procedure in the surgical treatment of secondary peritonitis. This study compared postoperative mortality and complication rates between VAC and primary abdominal closure (PAC). Method: This retrospective chart review included all patients diagnosed with secondary peritonitis who underwent laparotomy between 2010 and 2019. Data were collected from six hospitals within Southern Denmark, covering a population of approximately 1,225,000 inhabitants. Results: The study involved 315 patients (139 in the PAC and 176 in the VAC groups). In the VAC group, BMI, ASA, SOFA, MPI, and four quadrant contamination was significantly higher at the index operation. There were no significant differences in nonadjusted and adjusted postoperative mortality at 30 days, 90 days, and 1 year, with cumulative values of 13%, 16%, and 21%, respectively, compared with 16%, 21%, and 31%, in the PAC group (p = 0.519, p = 0.380, and p = 0.051, respectively). Cumulative adjusted surgical postoperative complications at 30 days, 90 days, and 1 year, as assessed by the comprehensive complication index, was significantly higher in the PAC group. Reoperations were significantly more common in the PAC group. The total length of the intensive care unit admission was significantly longer in the VAC group, with a mean of 9.0 +/- 12.1 versus 6.7 +/- 12.1 days (p < 0.001). Conclusion: VAC after laparotomy for secondary peritonitis did not significantly reduce mortality but increased ICU stay, whereas primary closure led to higher surgical complication rates and reoperations.
C1 [Rajabaleyan, Pooya; Vang, Ask; Khalaf, Sardar; Ladegaard, Anna Gosvig; Qvist, Niels; Ellebaek, Mark Bremholm] Odense Univ Hosp, Res Unit Surg, Odense, Denmark.
   [Rajabaleyan, Pooya; Moller, Soren; Qvist, Niels; Ellebaek, Mark Bremholm] Odense Univ Hosp, Open Patient Data Explorat Network OPEN, Odense, Denmark.
   [Rajabaleyan, Pooya; Moller, Soren; Qvist, Niels; Ellebaek, Mark Bremholm] Univ Southern Denmark, Dept Clin Res, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark
RP Rajabaleyan, P (通讯作者)，Odense Univ Hosp, Res Unit Surg, Odense, Denmark.; Rajabaleyan, P (通讯作者)，Odense Univ Hosp, Open Patient Data Explorat Network OPEN, Odense, Denmark.
EM Pooya.rajabaleyan@skane.se
RI ; Möller, Sören/X-8738-2019
OI Rajabaleyan, Pooya/0000-0002-6882-9427; Ellebaek, Mark
   Bremholm/0000-0001-6550-7505; Möller, Sören/0000-0003-0858-4269; ,
   Sardar Khalaf/0009-0008-4358-4663
FU Region Syddanmark
FX The authors have nothing to report.
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NR 64
TC 4
Z9 7
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD FEB
PY 2025
VL 49
IS 2
BP 387
EP 400
DI 10.1002/wjs.12472
EA JAN 2025
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA W0Z9Z
UT WOS:001395128800001
PM 39794299
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Kuang, XW
   Liang, ZY
   Xia, YJ
   Shan, MJ
   Hao, Y
   Liu, H
   Wang, Z
   He, QJ
   Xia, C
   Feng, C
   Chang, GJ
   Wang, YB
AF Kuang, Xinwen
   Liang, Zhengyun
   Xia, Yijun
   Shan, Mengjie
   Hao, Yan
   Liu, Hao
   Wang, Zhi
   He, Qianjun
   Xia, Chao
   Feng, Cheng
   Chang, Guojing
   Wang, Youbin
TI Hydrogen-Rich Saline Combined With Vacuum Sealing Drainage Promotes
   Wound Healing by Altering Biotin Metabolism
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE biotin metabolism; hydrogen-rich saline; metabolomics; oxidative stress;
   vacuum sealing drainage; wound healing
ID WATER PROTECTS; PRESSURE; INFLAMMATION; MECHANISM; CYTOKINES; HEALTHY;
   INJURY; DAMAGE; MICE
AB Impaired wound healing affects the life quality of patients and causes a substantial financial burden. Hydrogen-rich medium is reported to have antioxidant and anti-inflammatory effects. However, the role of hydrogen-rich saline (HRS) in cutaneous wound healing remains largely unexplored, especially by metabolomics. Thus, untargeted metabolomics profiling was analysed to study the effects and mechanism of HRS combined with vacuum sealing drainage (VSD) in a rabbit full-thickness wound model. Our results indicated that the combination treatment of HRS and VSD could accelerate wound healing. In vitro experiments further confirmed its effects on HaCaT keratinocytes. We found that 45 metabolites were significantly changed between the VSD + HRS group and the VSD + saline-treated group. Pathway enrichment analysis indicated that biotin metabolism was the potential target pathway. The biochemical interpretation analysis demonstrated that combining HRS and VSD might enhance mitochondrial function, ATP synthesis, and GSH homeostasis by altering biotin metabolism. The detection of representative indicators of oxidative stress supported the critical metabolic pathway analysis as well. In summary, VSD combined with HRS might provide a new strategy to enhance wound healing.
C1 [Kuang, Xinwen; Liang, Zhengyun; Xia, Yijun; Shan, Mengjie; Hao, Yan; Liu, Hao; Wang, Zhi; Feng, Cheng; Chang, Guojing; Wang, Youbin] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Plast Surg, Beijing, Peoples R China.
   [Liang, Zhengyun] Shenzhen Inst Dermatol, Shenzhen Ctr Chron Dis Control, Dept Dermatol, Shenzhen, Peoples R China.
   [He, Qianjun; Xia, Chao] Shanghai Jiao Tong Univ, Shanghai Key Lab Hydrogen Sci, Shanghai, Peoples R China.
   [He, Qianjun; Xia, Chao] Shanghai Jiao Tong Univ, Ctr Hydrogen Sci, Sch Mat Sci & Engn, Shanghai, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Wang, YB (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Plast Surg, Beijing, Peoples R China.
EM wybenz@sina.com
RI He, Qianjun/M-2642-2013
OI Kuang, Xinwen/0000-0002-6876-7844
FU Clinical Research Special Fund of Peking Union Medical College Hospital,
   Peking Union Medical College;  [2022-PUMCH-B-040]
FX This research was funded by the Clinical Research Special Fund of Peking
   Union Medical College Hospital, Peking Union Medical College
   (2022-PUMCH-B-040). We thank Nanobubble Technology (Shanghai, China) for
   providing the hydrogen-rich water-generating electrolytic bottles.
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NR 60
TC 1
Z9 1
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JAN 13
PY 2025
VL 29
IS 1
AR e70292
DI 10.1111/jcmm.70292
PG 14
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA S0R8H
UT WOS:001395413000001
PM 39804806
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Leary, OP
   Setty, A
   Gong, JH
   Ali, R
   Fridley, JS
   Fisher, CG
   Sahgal, A
   Rhines, LD
   Reynolds, JJ
   Lazary, A
   Laufer, I
   Gasbarrini, A
   Dea, N
   Verlaan, JJ
   Bettegowda, C
   Boriani, S
   Mesfin, A
   Luzzati, A
   Shin, JH
   Cecchinato, R
   Hornicek, FJ
   Goodwin, ML
   Gokaslan, ZL
AF Leary, Owen P.
   Setty, Aayush
   Gong, Jung Ho
   Ali, Rohaid
   Fridley, Jared S.
   Fisher, Charles G.
   Sahgal, Arjun
   Rhines, Laurence D.
   Reynolds, Jeremy J.
   Lazary, Aron
   Laufer, Ilya
   Gasbarrini, Alessandro
   Dea, Nicolas
   Verlaan, Jorrit-Jan
   Bettegowda, Chetan
   Boriani, Stefano
   Mesfin, Addisu
   Luzzati, Alessandro
   Shin, John H.
   Cecchinato, Riccardo
   Hornicek, Francis J.
   Goodwin, Matthew L.
   Gokaslan, Ziya L.
TI Prevention and Management of Posterior Wound Complications Following
   Oncologic Spine Surgery: Narrative Review of Available Evidence and
   Proposed Clinical Decision-Making Algorithm
SO GLOBAL SPINE JOURNAL
LA English
DT Article
DE surgical site infection; wound dehiscence; spinal oncology; clinical
   algorithm; spine surgery
ID SURGICAL-SITE-INFECTION; VANCOMYCIN POWDER; RISK-FACTORS; EN-BLOC;
   ANTIBIOTIC-THERAPY; FUSION; MORTALITY; OUTCOMES; DISEASE; QUALITY
AB Study DesignNarrative Review.ObjectiveContextualized by a narrative review of recent literature, we propose a wound complication prevention and management algorithm for spinal oncology patients. We highlight available strategies and motivate future research to identify optimal and individualized wound management for this population.MethodsWe conducted a search of recent studies (2010-2022) using relevant keywords to identify primary literature in support of current strategies for wound complication prevention and management following spine tumor surgery. When primary literature specific to spine tumor cases was not available, data were extrapolated from studies of other spine surgery populations. Results were compiled into a proposed clinical algorithm to guide practice considering available evidence.ResultsBased on available literature, we recommend individualized stratification of patients according to identifiable risk factors for wound complication and propose several interventions which might be employed preventatively, including intrawound antibiotic administration, negative pressure wound therapy, and primary flap closure of the surgical wound. Of these, the available evidence, weighing possible risks vs benefits, most strongly favors primary flap closure of surgical wounds, particularly for patients with multiple risk factors. A secondary algorithm to guide management of wound complications is also proposed.ConclusionsWound complications such as SSI and dehiscence remain a significant source of morbidity following spine tumor surgery. Triaging patients on an individualized basis according to risk factors for complication may aid in selecting appropriate prophylactic strategies to prevent these complications. Future research in this area is still needed to strengthen recommendations.
C1 [Leary, Owen P.; Setty, Aayush; Gong, Jung Ho; Ali, Rohaid; Fridley, Jared S.; Gokaslan, Ziya L.] Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Neurosurg, APC-6, Providence, RI 02903 USA.
   [Fisher, Charles G.; Dea, Nicolas] Univ British Columbia, Combined Neurosurg & Orthopaed Spine Program, Vancouver, BC, Canada.
   [Sahgal, Arjun] Univ Toronto, Sunnybrook Hosp, Dept Radiat Oncol, Toronto, ON, Canada.
   [Rhines, Laurence D.] Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX USA.
   [Reynolds, Jeremy J.] Oxford Univ Hosp, Oxford Spinal Surg Unit, Oxford, England.
   [Lazary, Aron] Buda Hlth Ctr, Natl Ctr Spinal Disorders, Budapest, Hungary.
   [Laufer, Ilya] NYU, Grossman Sch Med, Dept Neurosurg, New York, NY USA.
   [Gasbarrini, Alessandro; Boriani, Stefano] Univ Bologna, Ist Ortoped Rizzoli, Bologna, Italy.
   [Verlaan, Jorrit-Jan] Univ Med Ctr Utrecht, Dept Orthoped, Utrecht, Netherlands.
   [Bettegowda, Chetan] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD USA.
   [Mesfin, Addisu] Georgetown Univ, Medstar Orthopaed Inst, Sch Med, Dept Orthopaed Surg, Washington, DC USA.
   [Luzzati, Alessandro; Cecchinato, Riccardo] Ambrogio Hosp, IRCCS Galeazzi, Milan, Italy.
   [Shin, John H.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA USA.
   [Hornicek, Francis J.] Univ Miami, Miller Sch Med, Dept Orthopaed, Miami, FL USA.
   [Goodwin, Matthew L.] Washington Univ, Sch Med St Louis, Dept Orthopaed Surg, St Louis, MO USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   University of British Columbia; University of Toronto; Sunnybrook
   Research Institute; Sunnybrook Health Science Center; University of
   Texas System; UTMD Anderson Cancer Center; New York University; IRCCS
   Istituto Ortopedico Rizzoli; University of Bologna; Utrecht University;
   Utrecht University Medical Center; Johns Hopkins University; Georgetown
   University; IRCCS Istituto Ortopedico Galeazzi; Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   Harvard Medical School; University of Miami; Saint Louis University;
   Washington University (WUSTL)
RP Leary, OP (通讯作者)，Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Neurosurg, APC-6, Providence, RI 02903 USA.
EM owen_leary@brown.edu
RI ; Lazary, Aron/LKL-6634-2024; Cecchinato, Riccardo/H-3283-2013
OI Gong, Jung Ho/0000-0003-0382-8279; Lazary, Aron/0000-0002-0157-719X;
   Leary, Owen/0000-0002-6282-828X; 
FU AO Spine
FX The authors would additionally like to thank Kendall Rivera-Lane BA for
   contributing the original illustration for this article; Samathalee
   Obiorah MD, Albert Woo MD, and Luke Soliman BS for contributing to an
   earlier version of the drafted text; and Kyle Mueller MD for insights
   related to the use of negative pressure wound therapy in spinal surgery.
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NR 121
TC 7
Z9 7
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2192-5682
EI 2192-5690
J9 GLOB SPINE J
JI Glob. Spine J.
PD JAN
PY 2025
VL 15
IS 1_SUPPL
SU 1_SUPPL
SI SI
BP 143S
EP 156S
DI 10.1177/21925682241237486
PG 14
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA S3B6R
UT WOS:001397023800011
PM 39801119
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ren, SW
   Liu, H
   Chang, ZQ
AF Ren, Shiwei
   Liu, Huan
   Chang, Zhengqi
TI Effectiveness of negative pressure wound therapy in treating deep
   surgical site infections after spine surgery: a meta-analysis of
   single-arm studies
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Surgical site infection; Negative pressure wound therapy; Spinal
   surgery; Orthopaedic surgery; Infection
ID VACUUM-ASSISTED-CLOSURE; POSTOPERATIVE INFECTIONS; MANAGEMENT; FUSION;
   INSTRUMENTATION; EFFICACY
AB BackgroundOne of the common complications in spinal surgery patients is deep surgical site infections (SSIs). Deep SSIs refer to infections that involve the deeper soft tissues of the incision, such as the fascia and muscle layers. This complication can lead to prolonged hospitalization, repeated surgeries, and even life-threatening conditions. In recent years, Negative Pressure Wound Therapy (NPWT) has been widely used as an effective wound healing method in the management of post-surgical infections. However, there is a lack of systematic research and comprehensive reviews regarding the exact effectiveness of NPWT in the treatment of deep SSIs following spinal surgery. Therefore, we conducted this meta-analysis to explore the efficacy of NPWT in treating deep SSIs after spinal surgery, aiming to provide clearer evidence to support clinical practice.MethodsA comprehensive search of databases, including CNKI, Wanfang data, VIP data, CBM, PubMed, Embase, Cochrane Library, and Web of Science, was conducted for studies up to August 20, 2024, examining the use of NPWT in treating SSIs after spinal surgery. Using Stata 15.0 software, we employed either fixed or random models to calculate combined effect sizes, depending on the level of heterogeneity observed.ResultsOf the 571 publications initially screened, 19 studies meeting the inclusion criteria were selected for analysis. The meta-analysis revealed that the mean duration of vacuum sealing drainage (VSD) treatment was 17.45 days [95% confidence interval (CI) (11.63 days, 23.28 days)], and the mean number of VSD uses was 2.57 times[95% CI (1.53times, 3.60times)]. Additionally, the recurrence rate of infection post-discharge was 2% (95% CI = 0-4%). The reoperation rate for internal fixation in NPWT-treated patients was 4% (95% CI = 0-14%).ConclusionAvailable evidence supports the effectiveness of NPWT in treating deep SSIs following spinal surgery, suggesting its clinical utility. However, further studies are needed to compare NPWT with other treatment options for SSIs management.RegistrationsPROSPERO CRD42024612412.
C1 [Ren, Shiwei; Liu, Huan; Chang, Zhengqi] 960th Hosp PLA, Dept Orthopaed, 25 Shifan Rd, Jinan 250031, Shandong, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthopaed, 25 Shifan Rd, Jinan 250031, Shandong, Peoples R China.
EM 26766771@qq.com
RI liu, huan/NDS-1676-2025
FU Natural Science Foundation of Shandong Province
FX This study benefited from excellent guidance provided by the journal
   editors and valuable feedback from the reviewers, to whom we extend our
   sincere thanks for their support and assistance throughout the research
   process.
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NR 74
TC 2
Z9 4
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD JAN 13
PY 2025
VL 20
IS 1
AR 44
DI 10.1186/s13018-025-05463-2
PG 12
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA S3U2X
UT WOS:001397508700001
PM 39800681
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Roman, M
   Nizamoglu, MA
   Biosse-Duplan, G
   Gearon, D
   Abood, A
   Anderson, K
AF Roman, Manuela
   Nizamoglu, Metin Ali
   Biosse-Duplan, Garance
   Gearon, Dan
   Abood, Ahid
   Anderson, Keith
TI Open lower limb fracture reconstruction in the elderly population: the
   experience of a major trauma centre
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Review
DE Lower limb trauma; Elderly population; BOAST 4 guidelines;
   Reconstruction
ID FREE-TISSUE TRANSFER; MANAGEMENT; INFECTION; AUDIT
AB Purpose Management of the elderly patients presenting with open lower limb fractures is challenging due to physiological changes and pre-existing co-morbidities. The aim of this study was to assess the compliance with the British Orthopaedic Association's Standards for Trauma Number 4 (BOAST 4) guidelines in this patient group. Methods The study included a retrospective analysis of all the patients aged > 65 years old admitted with open lower limb fracture between 2017 and 2019 to a major trauma centre (MTC) in East of England. Results Our study included 91 patients presenting with lower limb trauma. The most common injury was a Gustilo and Anderson grade IIIB (39.6%). 30.8% of the study population received antibiotics within 1 h, 89% had debridement and bone stabilization within 24 h. Mean time to definitive soft tissue coverage was 3 days, with 66% of the study group having their fracture fixed and soft tissue coverage within 72 h. 52% had direct wound closure, with 9% having an incisional topical negative pressure wound therapy, 17% had a local flap and 5% patients had a free flap. The most common complication was wound dehiscence. The wounds closed without an incisional topical negative pressure wound therapy have shown a dehiscence rate of 15.4%, compared to 0% in the patients who had one. Conclusion Our study suggests that BOAST 4 compliance in the population > 65 years is comparable to the younger population. It is likely that the lower energy injury profile enables early definitive management even in the presence of age related co-morbidities.
C1 [Roman, Manuela; Nizamoglu, Metin Ali; Biosse-Duplan, Garance; Gearon, Dan; Abood, Ahid; Anderson, Keith] Addenbrookes Hosp, Dept Plast & Reconstruct Surg, Hills Rd, Cambridge CB2 0QQ, England.
C3 Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's
   Hospital; University of Cambridge
RP Roman, M (通讯作者)，Addenbrookes Hosp, Dept Plast & Reconstruct Surg, Hills Rd, Cambridge CB2 0QQ, England.
EM Manuela.Roman@nhs.net
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NR 21
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD DEC
PY 2025
VL 51
IS 1
AR 20
DI 10.1007/s00068-024-02688-4
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA S4P0C
UT WOS:001398048600002
PM 39815042
DA 2026-07-24
ER
PT J
AU Arai, S
   Coryell, J
   Johnson, T
   Chow, RS
   Amsellem, PM
AF Arai, Shiori
   Coryell, Jessi
   Johnson, Tiffany
   Chow, Rosalind S.
   Amsellem, Pierre M.
TI Application of negative pressure wound therapy to partially closed
   median sternotomy in a dog
SO CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS; SEPTIC PERITONITIS; DISTAL
   EXTREMITY; MANAGEMENT; MEDIASTINITIS; INFECTIONS
AB A 6-year-old Labrador retriever dog with a history of pneumonia was presented because of an acute onset of dull mentation and coughing. Diagnostic imaging and cytology revealed a pneumothorax, pneumomediastinum, and pleural effusion, consistent with pyothorax. The dog underwent exploratory sternotomy for lung lobectomy of the right cranial and middle lung lobes. Persistent pneumothorax and pleural effusion were present after surgery, and the sternotomy site dehisced 6 d postoperatively. A second CT scan revealed persistent consolidation of the left cranial lung lobe and continued pneumothorax and pleural effusion. A left cranial lung lobectomy was done on the 8th day following initial surgery. Anincisional infection was determined to be associated with multidrug-resistant Escherichia coliinfection. Due to persistent pleural and incisional drainage, a third exploratory sternotomy was required, which revealed dehiscence of the surgical site and an unstable sternal repair with fractured sternebrae. The sternotomy site was left partially closed and negative pressure wound therapy (NPWT) was applied. No complications with NPWT were encountered, and the incision healed appropriately.
C1 [Arai, Shiori; Coryell, Jessi; Johnson, Tiffany; Chow, Rosalind S.; Amsellem, Pierre M.] Univ Minnesota, Coll Vet Med, Vet Clin Sci Dept, 1352 Boyd Ave, St Paul, MN 55108 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities
RP Arai, S (通讯作者)，Univ Minnesota, Coll Vet Med, Vet Clin Sci Dept, 1352 Boyd Ave, St Paul, MN 55108 USA.
EM sarai@colostate.edu
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NR 35
TC 0
Z9 0
U1 0
U2 0
PU CANADIAN VET MED ASSOC
PI OTTAWA
PA 339 BOOTH ST, OTTAWA, ONTARIO K1R 7K1, CANADA
SN 0008-5286
J9 CAN VET J
JI Can. Vet. J.-Rev. Vet. Can.
PD JAN
PY 2025
VL 66
IS 1
PG 110
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA S4T5W
UT WOS:001398167600009
DA 2026-07-24
ER
PT J
AU Zapletal, J
   Sehnal, B
   Dvorak, R
   Drienko, M
   Vlk, R
   Halaska, MJ
   Rob, L
AF Zapletal, Jan
   Sehnal, Borek
   Dvorak, Radim
   Drienko, Miroslav
   Vlk, Radovan
   Halaska, Michael J.
   Rob, Lukas
TI Abdominal wound dehiscence after appendectomy during pregnancy treated
   by negative pressure wound therapy with subsequent vaginal delivery: A
   case report and literature review
SO INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
LA English
DT Review
DE appendicitis; negative pressure wound therapy; obstetrics; pregnancy;
   surgical site infection; vacuum-assisted closure system; wound
   dehiscence
ID VACUUM-ASSISTED CLOSURE; SURGICAL-SITE INFECTION; CESAREAN DELIVERY;
   MANAGEMENT; WOMEN
AB Negative pressure wound therapy (NPWT) is a very effective method in the treatment of dehiscent, infected, and non-healing wounds. Difficult wound healing occurs especially in late pregnancy due to the rapid enlargement of the uterus and the constantly increasing tension of the entire abdominal wall. In cases of dehiscence of the surgical wound during pregnancy, proper subsequent treatment is needed, where it is necessary to consider the safety of the mother as well as the fetus. We report the case of a 30-week pregnant patient who was surgically treated for acute appendicitis in pregnancy with an open appendectomy approach. Postoperative complications resulted in wound dehiscence with complete defect in fascia, which was treated with negative V.A.C. ATS (R) Therapy System. The therapy was started in the 30th week of pregnancy and continued until delivery with regular check-ups and regular redressing of the vacuum-assisted closure (VAC) system. At 38 weeks of pregnancy, the patient delivered vaginally with continued VAC therapy in situ. The final suture took place 3 days after vaginal delivery. Non-healing wounds with abdominal wall defects should be treated using a multidisciplinary approach, and NPWT can be used. This therapy can also be used during pregnancy. Vaginal delivery is preferred because it reduces the risk of further formation or deepening of the abdominal wall defect after a sufficient time interval from the start of the treatment. This complex case with a literature review of surgical complications in pregnancy treated with NPWT therapy highlights the advantage of a multidisciplinary approach.
C1 [Zapletal, Jan; Sehnal, Borek; Vlk, Radovan; Halaska, Michael J.; Rob, Lukas] Charles Univ Prague, Fac Med 3, Dept Obstet & Gynecol, Srobarova 1150-50, Prague 10, Czech Republic.
   [Zapletal, Jan; Sehnal, Borek; Dvorak, Radim; Drienko, Miroslav; Vlk, Radovan; Halaska, Michael J.; Rob, Lukas] Univ Hosp Kralovske Vinohrady, Prague, Czech Republic.
   [Dvorak, Radim; Drienko, Miroslav] Charles Univ Prague, Fac Med 3, Dept Surg, Prague, Czech Republic.
C3 Charles University Prague; University Hospital Vinohrady; Charles
   University Prague
RP Zapletal, J (通讯作者)，Charles Univ Prague, Fac Med 3, Dept Obstet & Gynecol, Srobarova 1150-50, Prague 10, Czech Republic.; Zapletal, J (通讯作者)，Fac Hosp Kralovske Vinohrady, Srobarova 1150-50, Prague 10, Czech Republic.
EM honza.zaple@seznam.cz
RI Zapletal, Jan/NES-4488-2025; Sehnal, Borek/P-6853-2017; Rob,
   Lukas/AFQ-9215-2022
OI Zapletal, Jan/0000-0003-2705-2970; Sehnal, Borek/0000-0003-2622-2181; 
FU Cooperation program, Maternal and Childhood Care [207 035]; Medicine,
   Charles University in Prague
FX This study was supported by the Cooperation program, Maternal and
   Childhood Care 207 035, Third Faculty of Medicine, Charles University in
   Prague
CR Adamina M, 2022, SURG ENDOSC, V36, P8699, DOI 10.1007/s00464-022-09625-9
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NR 30
TC 2
Z9 2
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7292
EI 1879-3479
J9 INT J GYNECOL OBSTET
JI Int. J. Gynecol. Obstet.
PD JUL
PY 2025
VL 170
IS 1
BP 150
EP 156
DI 10.1002/ijgo.16155
EA JAN 2025
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 3XV2D
UT WOS:001398180100001
PM 39825682
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Guo, HH
   Xue, ZQ
   Mei, SW
   Li, TF
   Yu, HY
   Ning, T
   Fu, YB
AF Guo, Huihui
   Xue, Zhenqiang
   Mei, Siwei
   Li, Tengfei
   Yu, Haiyang
   Ning, Tao
   Fu, Yongbin
TI Clinical efficacy of antibiotic-loaded bone cement and negative pressure
   wound therapy in multidrug-resistant organisms diabetic foot ulcers: a
   retrospective analysis
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE multidrug-resistant organisms; diabetic foot ulcers; antibiotic-loaded
   bone cement; vacuum sealing drainage; clinical efficacy
ID VACUUM-SEALING DRAINAGE; RISK-FACTORS; INFECTION; SKIN
AB Objective The purpose of this study was to investigate the clinical efficacy of antibiotic-loaded bone cement (ALBC) combined with Negative pressure wound therapy (NPWT) aspiration technique in the treatment of multidrug-resistant diabetic foot ulcers (MDRO-DFUs). Methods A retrospective analysis of the clinical data of 80 patients with MDROs-DFU who were used Vacuum sealing drainage (VSD) as NPWT excipient and met the inclusion criteria from January 2019 to January 2024 at our hospital. Patients were divided into an experimental group and a control group, with 40 cases in each. The control group received conventional treatment, routine debridement, and NPWT treatment, while the experimental group received ALBC treatment in addition to the treatment plan of the control group. Measurements of blood inflammatory indicators, foot hemodynamic indicators, wound bacterial clearance time, wound healing time, and hospital stay were taken before and after treatment for both groups. Results Inflammatory indexes, Vascular endothelial growth factor(VEGF), and internal diameter of dorsalis pedis arteriosus of both groups after treatment were significantly better than those before treatment, and the improvement of the experimental group was more obvious than that of the control group; the experimental group had a significantly shorter time of trauma bacterial turnover, healing time of trauma, and hospitalization time compared with that of the control group (P<0.05).
C1 [Guo, Huihui; Xue, Zhenqiang; Mei, Siwei; Li, Tengfei; Yu, Haiyang; Ning, Tao; Fu, Yongbin] Fuyang City Peoples Hosp, Dept Orthoped, Fuyang, Peoples R China.
RP Ning, T; Fu, YB (通讯作者)，Fuyang City Peoples Hosp, Dept Orthoped, Fuyang, Peoples R China.
EM doctorning87@163.com; 95224436@qq.com
RI YU, haiyang/GPX-1772-2022; guo, huihui/GYQ-8331-2022; Li,
   Tengfei/ABH-1406-2020
FU Research Fund Project of Anhui Medical University: Clinical Study of
   Lateral Distraction of Tibial Periosteum in the Treatment of Wagner I/IV
   Diabetic Foot [2022xkj225]; Analysis of clinical efficacy of transverse
   tibial bone transport in the treatment of diabetic foot ulcer
   [FK20245504]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. Research Fund Project of
   Anhui Medical University: Clinical Study of Lateral Distraction of
   Tibial Periosteum in the Treatment of Wagner I/IV Diabetic Foot
   (2022xkj225); Analysis of clinical efficacy of transverse tibial bone
   transport in the treatment of diabetic foot ulcer(FK20245504). The
   funders had no involvement in the study's design, data collection and
   analysis, publication decision, or manuscript writing.
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NR 63
TC 14
Z9 20
U1 3
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD JAN 3
PY 2025
VL 14
AR 1521199
DI 10.3389/fcimb.2024.1521199
PG 10
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA S5E8W
UT WOS:001398461400001
PM 39831106
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ceran, F
   Bozkurt, M
   Karakol, P
AF Ceran, Fatih
   Bozkurt, Mehmet
   Karakol, Percin
TI Effectiveness of the combined therapy in the treatment of chronic
   non-healing wounds in patients with autoimmune diseases
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Autoimmune; Chronic wounds; Acellular dermal; NPWT; Skin grafts; Bone
   marrow aspirate; matrix
ID NEGATIVE-PRESSURE DRESSINGS; MESENCHYMAL STEM-CELLS; THICKNESS
   SKIN-GRAFTS; FOREFOOT SURGERY; BURNS; MANAGEMENT
AB Objective: Autoimmune diseases are systemic conditions that can have negative effects on wound healing. The objective of the present study was to investigate the efficacy of combining bone marrow-derived mesenchymal stem cells (BM-MSCs), acellular dermal matrix (ADM), split-thickness skin graft (STSG), and negative-pressure wound therapy (NPWT) for treating patients with autoimmune diseases and chronic non-healing wounds. Methods: Thirty-four patients with autoimmune diseases and non-healing chronic wounds of the lower extremities between 2012 and 2023 were included in the study. Among these, 18 patients had Beh & ccedil;et's disease, 8 patients had polyarteritis nodosa, and 8 patients had systemic lupus erythematosus. All patients underwent split-thickness skin grafting in external centers. The wounds were debrided, and BM-MSCs concentrate was injected into the wound base. A suitable ADM was applied to the wound. STSG were adapted onto the ADM. The grafts were closed with NPWT. Results: Patients were followed-up for an average of 1.2 years. No necrosis was observed at the wound sites of the post-operative patients. During long-term follow-up, no wounds were observed at the same sites. Conclusion: Although autoimmune diseases fall within the scope of rheumatology, the treatment of chronic non-healing wounds that accompany such diseases requires a multidisciplinary approach. We demonstrated that the combined use of BM-MSCs, ADM, STSG, and NPWT presents an effective approach in the healing of these types of wounds. (c) 2024 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Ceran, Fatih] Biruni Univ, Dept Plast Reconstruct & Aesthet Surg, Med Fac, Istanbul, Turkiye.
   [Bozkurt, Mehmet; Karakol, Percin] Bagcilar Training & Res Hosp, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkiye.
C3 Biruni University; Istanbul Bagcilar Training & Research Hospital
RP Ceran, F (通讯作者)，Eski Londra Asfalti 10, TR-34295 Istanbul, Turkiye.
EM fatihcrn@hotmail.com
RI Ceran, Fatih/JPK-6708-2023; BOZKURT, Mehmet/KFR-6152-2024
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   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Shanmugam VK, 2016, CURR DERMATOL REP, V5, P270, DOI 10.1007/s13671-016-0157-2
   Stokes TH, 2006, ANN PLAS SURG, V56, P649, DOI 10.1097/01.sap.0000202826.61782.c9
   Vojtassák J, 2006, NEUROENDOCRINOL LETT, V27, P134
   Yano K, 2016, MOD RHEUMATOL, V26, P211, DOI 10.3109/14397595.2015.1071456
   Yoshikawa T, 2008, PLAST RECONSTR SURG, V121, P860, DOI 10.1097/01.prs.0000299922.96006.24
NR 33
TC 5
Z9 5
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD FEB
PY 2025
VL 101
BP 126
EP 133
DI 10.1016/j.bjps.2024.11.033
EA DEC 2024
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA S5H4B
UT WOS:001398526900001
PM 39731901
DA 2026-07-24
ER
PT J
AU Hou, SL
   Shi, ZY
   Li, XW
   Yang, R
   Song, Y
   Zeng, ZL
AF Hou, Shulin
   Shi, Zeyao
   Li, Xiaowen
   Yang, Ru
   Song, Yan
   Zeng, Zhaolan
TI Combined negative pressure wound therapy with new wound dressings to
   repair a ruptured giant omphalocele in a neonate: a case report and
   literature review
SO BMC PEDIATRICS
LA English
DT Article
DE Negative pressure wound therapy; Infant, Newborn; Giant omphalocele
ID FIBROBLAST-GROWTH-FACTOR; MANAGEMENT
AB BackgroundCurrent treatment of giant omphalocele in newborns is not standardized. The main treatments include one-time repair and staged surgery using synthetic and biologic mesh, or silos. However, surgery can lead to various postoperative complications. Recently, negative pressure wound therapy (NPWT) has been recommended as an effective method for giant omphalocele. We adopted NPWT and some new wound dressings for a case of ruptured giant omphalocele. Vaseline gauze (VG), followed by silver-containing sodium carboxymethylcellulose dressing(CMC-Ag)was used to control infection. NPWT was mainly performed to promote granulation and accelerated healing. Recombinant human basic fibroblast growth factor (Rh-bFGF) was used to heal the wound. No studies have conducted NPWT and new wound dressings healing the wound of ruptured giant omphalocele. Therefore, we present our management experience in this case.Case presentationThe patient was a baby boy aged 2 days, weighing 2930 g. He was diagnosed with a giant omphalocele with a partial intestine exposed. Two hours after admission, the baby underwent a silo placement. The herniation of the bowel was gradually reduced into the abdominal cavity. At the age of 13 days, the stitches at the bottom of the silo fell off, and the liver was exposed with the defect size about 8 cm x 10 cm. The hole failed to be repaired by surgery. We used VG and CMC-Ag patched on the defect hole. After creating a moist and fresh environment, NPWT was then applied mainly to extract excess fluid and promote granulation. CMC-Ag was performed for 19 days when the wound showed no exudate or infection. NPWT was stopped at the age of 47 days when the granulation tissue was fully formed with the defect size reduced to 4.5 cm x 3.5 cm. After halting the NPWT, the wound was managed with Rh-bFGF and VG. At the age of 2 months, the wound was reduced to 1 cm x 1 cm with satisfactory epithelialization.ConclusionsNPWT is a safe and effective alternative therapy for the repair of giant omphalocele. CMC-Ag can help control wound infection and manage exudate and Rh-bFGF promotes wound healing. NPWT combined with new wound dressings can effectively manage ruptured giant omphalocele.Clinical trial numberNot applicable.
C1 [Hou, Shulin; Shi, Zeyao; Li, Xiaowen; Yang, Ru; Song, Yan; Zeng, Zhaolan] Sichuan Univ, West China Second Univ Hosp, Dept Neonatol Nursing, 20,Sect 3,South Renmin Rd, Chengdu, Sichuan Provinc, Peoples R China.
   [Hou, Shulin; Shi, Zeyao; Li, Xiaowen; Yang, Ru; Song, Yan; Zeng, Zhaolan] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University
RP Shi, ZY; Li, XW (通讯作者)，Sichuan Univ, West China Second Univ Hosp, Dept Neonatol Nursing, 20,Sect 3,South Renmin Rd, Chengdu, Sichuan Provinc, Peoples R China.; Shi, ZY; Li, XW (通讯作者)，Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu 610041, Sichuan, Peoples R China.
EM zeyao-shi@scu.edu.cn; 976682704@qq.com
OI Junco, Judy Von/0009-0003-5977-5249
CR Abello C, 2021, J PEDIATR SURG, V56, P1068, DOI 10.1016/j.jpedsurg.2020.12.003
   Agarwal A, 2022, J ORTHOP TRAUMA, V36, pS1, DOI 10.1097/BOT.0000000000002431
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   Niu XF, 2017, ORTHOP TRAUMATOL-SUR, V103, P461, DOI 10.1016/j.otsr.2017.01.008
   Poteet SJ, 2021, EXPERT REV MED DEVIC, V18, P151, DOI 10.1080/17434440.2021.1882301
   Rentea RM, 2013, J SURG RES, V184, P658, DOI 10.1016/j.jss.2013.05.056
   Saijo H, 2017, WOUND REPAIR REGEN, V25, P972, DOI 10.1111/wrr.12609
   Saxena AK, 2018, MINERVA PEDIATR, V70, P289, DOI 10.23736/S0026-4946.17.05109-X
   Skarsgard ED, 2019, SEMIN PEDIATR SURG, V28, P89, DOI 10.1053/j.sempedsurg.2019.04.010
   Sönmez K, 2010, WORLD J PEDIATR, V6, P274, DOI 10.1007/s12519-010-0016-3
   Stoffan AP, 2012, J PEDIATR SURG, V47, P1555, DOI 10.1016/j.jpedsurg.2012.01.014
   Verla MA, 2019, SEMIN PEDIATR SURG, V28, P84, DOI 10.1053/j.sempedsurg.2019.04.007
   Yu MH, 2021, AM J TRANSL RES, V13, P9364
   Zong HQ, 2025, ENT-EAR NOSE THROAT, V104, pNP699, DOI 10.1177/01455613221150571
NR 33
TC 5
Z9 6
U1 1
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD JAN 18
PY 2025
VL 25
IS 1
AR 44
DI 10.1186/s12887-024-05261-5
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA S5Z6B
UT WOS:001399002800002
PM 39825289
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gallagher, KE
   Alberto, EC
   Getchell, J
   Powell, J
   Cardenas, L
AF Gallagher, Kathy E.
   Alberto, Emily C.
   Getchell, John
   Powell, Jessie
   Cardenas, Luis
TI Expediting Acute Wound Healing by Integrating Multiple Therapeutic
   Strategies: A Case Series
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Acute Wounds; Complex Wounds; Wound Management; Wound Healing; Wound
   Dressings
ID MANAGEMENT
AB BACKGROUND: Traumatic injuries have increased risks for infection and progression to difficult-to-heal wounds. Often, they are inadequately treated with single-purpose dressings. Involving wound care specialists allows for integrating various advanced wound treatments. The objective of this report was to assess if healing rates correlated with using unique combination therapies. METHODS: An observational, prospective analysis was performed, reviewing patients with acute wounds from admission until healed. Systematic assessments were standardized, employing T.I.M.E. (tissue, infection /inflammation, moisture balance, edge/periwound). Key outcomes included wound progression, dimensions, treatments, healing time, and health care utilization metrics. RESULTS: A total of 124 patients with acute wounds up to 1120 cm healed using multimodal therapy. Median time to wound specialist consultation was 2 days. It was 3 determined that all patients were treated with a pure hypochlorous acid-based wound cleanser combined with negative pressure wound therapy, collagen, silver, manuka honey, and/or foam dressings. Median healing time was 19 days. Delays were associated with smoking, immunocompromise, and inability to obtain wound care supplies. CONCLUSIONS: Optimizing advanced therapeutic combinations with innovative dressings, including pHA and other beneficial components, has shown reduced health care utilization of acute wound patients by shortening healing time. The resulting decrease in dressing changes, follow-up appointments, and home care could increase patient satisfaction and improve outcomes.
C1 [Gallagher, Kathy E.; Powell, Jessie; Cardenas, Luis] Christiana Care, Acute Surg Wound Serv, Dept Surg, Newark, DE USA.
   [Gallagher, Kathy E.; Alberto, Emily C.; Getchell, John; Powell, Jessie; Cardenas, Luis] Christiana Care, Dept Surg, Newark, DE USA.
C3 Christiana Care Health System; Christiana Care Health System
RP Gallagher, KE (通讯作者)，2471 Everetts Corner Rd, Hartly, DE 19953 USA.
EM kathy.e.gallagher@gmail.com
CR Alberto EC, 2022, WOUND MANAG PREV, V68, P20, DOI 10.25270/wmp.2022.12.2024
   Diehm YF, 2021, PLAST RECONSTR SURG, V147, p43S, DOI 10.1097/PRS.0000000000007610
   Ennis W, 2020, Vascular News
   Felte R, 2016, CUREUS J MED SCIENCE, V8, DOI 10.7759/cureus.865
   Gallagher KE, 2021, S ADV WOUND CAR OCT
   Khalil H, 2017, INT WOUND J, V14, P1340, DOI 10.1111/iwj.12809
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Leaper DJ, 2012, INT WOUND J, V9, P1, DOI 10.1111/j.1742-481X.2012.01097.x
   Lindholm C, 2016, INT WOUND J, V13, P5, DOI 10.1111/iwj.12623
   Nussbaum SR, 2018, VALUE HEALTH, V21, P27, DOI 10.1016/j.jval.2017.07.007
   Schubert S, 2022, PHYS MED REH CLIN N, V33, P805, DOI 10.1016/j.pmr.2022.06.006
   Schultz GS, 2003, WOUND REPAIR REGEN, V11, pS1, DOI 10.1046/j.1524-475X.11.s2.1.x
   Sen CK, 2021, ADV WOUND CARE, V10, P281, DOI 10.1089/wound.2021.0026
   Sinha SN, 2022, AUST J GEN PRACT, V51, P827, DOI 10.31128/AJGP-06-22-6462
   Wilkinson HN, 2020, OPEN BIOL, V10, DOI 10.1098/rsob.200223
NR 15
TC 2
Z9 2
U1 0
U2 3
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD DEC
PY 2024
VL 70
IS 4
AR 23119
DI 10.25270/wmp.23119
PG 10
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA S7J5R
UT WOS:001399939300005
PM 39788879
DA 2026-07-24
ER
PT J
AU Fligor, CW
   Duplechain, AB
   Chaffin, AE
AF Fligor, Caleb W.
   Duplechain, Abby B.
   Chaffin, Abigail E.
TI A 12-Month Retrospective Review of Pressure Injury Plastic Surgical Flap
   Techniques Utilizing Pure Hypochlorous Acid (pHA) Preserved Wound
   Solution for Wound Bed Preparation
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Pressure Ulcer; Surgical Flaps; Surgical Wound; Therapeutic Irrigation;
   Wound Infection
ID RECONSTRUCTION; EXPERIENCE; SURFACE; COST
AB Background: The presence of heavy microbial colony formation, polymicrobial infection, and local altered pH contribute to the high rate of postoperative complications following surgical reconstruction of stage IV pressure injuries (PIs). Purpose: The objective of this study was to determine the rate of bacteria-related postoperative complications following surgical reconstruction of stage IV PIs in which a pure hypochlorous acid (pHA) antimicrobially preserved wound cleaning solution was used. Methods: This 1-year retrospective review evaluated the outcomes of patients who underwent surgical reconstructive treatment of chronic stage IV PI. Surgical management consisted of wide debridement, intraoperative cultures, and irrigation with 8 to 10 minutes indwelling of a pHA antimicrobially preserved wound cleaning solution prior to closure and application of incisional negative pressure wound therapy (iNPWT). Results: Thirteen patients (18 chronic, stage IV PIs) were included in the study. Intraoperative cultures were positive for 10/18 wounds (55.6%). A bacteria- related postoperative complication occurred in 1 patient (1/13, 7.7%; postoperative dehiscence requiring reoperation). Conclusions: Adjunctive irrigation and indwelling of a pHA antimicrobially preserved wound cleansing solution in the surgical management of chronic, stage IV PIs in this 1-year retrospective review resulted in a 7.7% bacteria-related postoperative complication rate.
C1 [Fligor, Caleb W.] Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70118 USA.
   [Duplechain, Abby B.] Tulane Univ, Sch Med, New Orleans, LA USA.
   [Chaffin, Abigail E.] Tulane Univ, Sch Med, Div Plast & Reconstruct Surg, New Orleans, LA USA.
C3 Tulane University; Tulane University; Tulane University
RP Fligor, CW (通讯作者)，Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70118 USA.
FU Urgo North America
FX Funding: Urgo North America provided financial support to Valerie
   Marmolejo, DPM, MS, MWC, with Scriptum Medica, for assistance in
   preparation of this manuscript.
CR Ahluwalia R, 2010, INT WOUND J, V7, P103, DOI 10.1111/j.1742-481X.2010.00662.x
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   [Anonymous], 2009, PREVENTION TREATMENT
   BioTech Inc, 2020, Hypochlorous acid (HOCI) for disinfection, antisepsis, and wound care in Core Categories 15.1, 15.2, and 13
   Borojeny LA, 2020, INT J PREVENTIVE MED, V11, DOI 10.4103/ijpvm.IJPVM_182_19
   Brem H, 2010, AM J SURG, V200, P473, DOI 10.1016/j.amjsurg.2009.12.021
   Chacon JMF, 2017, J TISSUE VIABILITY, V26, P108, DOI 10.1016/j.jtv.2016.12.003
   Chen CY, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023022
   Cox J, 2022, J WOUND OSTOMY CONT, V49, P21, DOI 10.1097/WON.0000000000000834
   Davis SC, 2021, WOUND MANAG PREV, V67, DOI 10.25270/wmp.2021.8.2431
   Derwin R, 2022, INT WOUND J, V19, P1397, DOI 10.1111/iwj.13733
   Djedovic G, 2017, INT WOUND J, V14, P1154, DOI 10.1111/iwj.12776
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   Foster Kevin N, 2019, Eplasty, V19, pe16
   Georgina G., 2007, Wounds UK, V3, P52, DOI DOI 10.1101/
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   Hiebert John M, 2016, Eplasty, V16, pe32
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   Lian C, 2019, INT WOUND J, V16, P570, DOI 10.1111/iwj.13013
   Maliyar K, 2020, ADV SKIN WOUND CARE, V33, P180, DOI 10.1097/01.ASW.0000655488.33274.d0
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   Ockerman KM, 2023, ADV SKIN WOUND CARE, V36, P385, DOI 10.1097/01.ASW.0000926628.10995.fc
   Padula WV, 2019, INT WOUND J, V16, P634, DOI 10.1111/iwj.13071
   Paker N, 2018, TURK J PH MED REHAB, V64, P322, DOI 10.5606/tftrd.2018.2175
   Papp AA, 2019, INT WOUND J, V16, P394, DOI 10.1111/iwj.13045
   Sakarya S, 2014, WOUNDS, V26, P342
   Thomson CH, 2017, ANN ROY COLL SURG, V99, P169, DOI 10.1308/rcsann.2016.0227
   Tsai YJ, 2023, FRONT SURG, V10, DOI 10.3389/fsurg.2023.970681
   Wongkietkachorn A, 2020, PRS-GLOB OPEN, V8, DOI 10.1097/GOX.0000000000002604
   Yamashita Y, 2023, J MED INVESTIG, V70, P101, DOI 10.2152/jmi.70.101
NR 36
TC 0
Z9 0
U1 1
U2 2
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD DEC
PY 2024
VL 70
IS 4
AR 24001
DI 10.25270/wmp.24001
PG 9
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA S7J5R
UT WOS:001399939300006
PM 39788876
DA 2026-07-24
ER
PT J
AU Esen, E
   Morkavuk, SB
   Turan, M
   Akyuz, S
   Guler, S
   Akgul, GG
   Bahcecioglu, IB
   Gulcelik, MA
   Yilmaz, KB
AF Esen, Ebru
   Morkavuk, Sevket Baris
   Turan, Mujdat
   Akyuz, Simay
   Guler, Sumeyra
   Akgul, Gokhan Giray
   Bahcecioglu, Ibrahim Burak
   Gulcelik, Mehmet Ali
   Yilmaz, Kerim Bora
TI The use of incisional negative-pressure wound therapy on high-risk
   patients with breast cancer after mastectomy
SO ASIAN JOURNAL OF SURGERY
LA English
DT Article
DE Breast cancer; Seroma; Wound complications; Incisional negative pressure
   wound therapy; iNPWT
ID SURGICAL SITE INFECTIONS; MANAGEMENT-SYSTEM; SEROMA FORMATION; SURGERY;
   CLOSURE; COMPLICATIONS; MECHANISM; REVERSAL; IMPACT; DELAY
AB Background: The main complications seen in patients who have undergone modified radical mastectomy (MRM) are seroma, surgical site infection, hematoma, wound dehiscence, flap necrosis, and nerve damage. While these complications lead to some problems the most feared effect in the early period is that they cause a delay in adjuvant treatment. Incisional Negative Pressure Wound Therapy (iNPWT) decreases wound dehiscence by reducing oedema and tension, especially in the incision line. This study aim to compare recovery times and wound site complications between patients treated with conventional wound dressings and patients treated with iNPWT after MRM. Methods: A retrospective screening was made of the data of 50 patients who underwent MRM because of breast cancer in the General Surgery Clinic of XXX Hospital between 2018 and 2022, and were at highrisk of wound site complications. Two groups were formed as 30 patients applied with iNPWT and 20 patients applied with conventional dressings. Results: The mean age of the 50 female patients was 53.58 years (range, 30-80 years). The most frequently seen complications were seroma (20 patients) and partial flap ischaemia (14 patients). The mean number of iNPWT applications was 1.30 (range, 1-2), and the mean number of days of application was 4.47 (range, 2-9). Postoperative seroma was observed in 8 patients in the iNPWT group and in 12 patients in the conventional dressings group (p = 0.018). Flap ischaemia and the probability of dehiscence was determined at a statistically significantly higher rate in the patients in the conventional dressings groups (p = 0.005, p = 0.021). Conclusion: The results of this study demonstrated that the use of iNPWT significantly reduced the amount of postoperative drainage, thereby contributing to early drain removal. Furthermore, iNPWT significantly reduced postoperative seroma, flap ischaemia, and flap dehiscence compared to conventional dressings. (c) 2024 Asian Surgical Association and Taiwan Society of Coloproctology. Publishing services by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Esen, Ebru] Istinye Univ, Bahcesehir Liv Hosp, Dept Surg Oncol, Istanbul, Turkiye.
   [Morkavuk, Sevket Baris; Turan, Mujdat; Akyuz, Simay; Guler, Sumeyra; Akgul, Gokhan Giray; Bahcecioglu, Ibrahim Burak; Gulcelik, Mehmet Ali; Yilmaz, Kerim Bora] Univ Hlth Sci, Gulhane Res & Training Hosp, Dept Gen Surg, Gen Dr Tevfik Saglam 1 Etlik, TR-06010 Ankara, Turkiye.
C3 Istinye University; University of Health Sciences Turkey; Gulhane
   Training & Research Hospital
RP Yilmaz, KB (通讯作者)，Univ Hlth Sci, Gulhane Res & Training Hosp, Dept Gen Surg, Gen Dr Tevfik Saglam 1 Etlik, TR-06010 Ankara, Turkiye.
EM borakerim@yahoo.com; kerimbora.yilmaz@sbu.edu.tr
RI gulcelik, mehmet ali/LKK-6450-2024; Akyüz, Simay/KXS-0711-2024; Yilmaz,
   Kerim Bora/HJI-8568-2023; MORKAVUK, Sevket Baris/ABB-3437-2021
OI gulcelik, mehmet ali/0000-0002-8967-7303; Akyüz,
   Simay/0000-0002-0464-8934; Bahçecioğlu, İbrahim
   burak/0000-0001-9417-3866; MORKAVUK, Sevket Baris/0000-0003-0441-0333
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
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NR 52
TC 3
Z9 5
U1 1
U2 7
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD JAN
PY 2025
VL 48
IS 1
BP 185
EP 192
DI 10.1016/j.asjsur.2024.07.333
EA DEC 2024
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA S9M9B
UT WOS:001401385000001
PM 39164174
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhang, Y
   Zhao, YY
   Liu, SG
   Yao, ZH
   Jin, ZK
   Ma, WL
AF Zhang, Yang
   Zhao, Yangyang
   Liu, Shuanggong
   Yao, Zihan
   Jin, Zikang
   Ma, Wanli
TI A novel approach for managing the incisions of tibial plateau fractures
   with soft tissue swelling
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Tibial plateau fractures; Soft tissue damage; Incision management;
   Clinical efficiency
ID VACUUM-ASSISTED-CLOSURE; INTERNAL-FIXATION; EXTERNAL FIXATION; OPEN
   REDUCTION; THERAPY; MECHANISM
AB To investigate the feasibility and clinical efficacy of a novel approach to managing the incisions used to treat tibial plateau fractures (TPFs) with soft tissue swelling. We retrospectively enrolled 64 patients with TPFs who underwent surgery at the Second Hospital of Shandong University. Patients were divided into two groups: Group A (n = 32) underwent early surgery with the novel incision management technique, and Group B (n = 32) underwent conventional surgery after swelling reduction. The perioperative data of the two groups were compared, including the time from injury to surgery, one-stage operation time, intraoperative blood loss, number of dressing changes, wound healing time, and hospitalization time. Preoperative and postoperative complications were assessed in both groups, and pain condition, degree of arthritis, limb function, imaging results, and quality of life were evaluated using validated scales. The time from injury to surgery, number of dressing changes, and hospitalization time in Group A were significantly lower than those in Group B (P < 0.05). There were no significant differences in one-stage operation time, intraoperative blood loss, or wound healing time between the two groups (P > 0.05). There were fewer preoperative and postoperative complications in Group A than in Group B (P < 0.05). The VAS and WOMAC scores were reduced in both groups (P < 0.05); Group A had lower VAS scores two weeks after surgery. There was no statistically significant difference in the WOMAC score between the groups. The modified Rasmussen functional and radiological scores were elevated in both groups (P < 0.05). There was no statistically significant difference between the two groups for the modified Rasmussen functional or radiological score at any of the time points (P > 0.05). In addition, the two groups did not differ in quality of life (P > 0.05). For patients with tibial plateau fractures without congestive blisters, open reduction and internal fixation at the early stage of swelling and wide-spacing interrupted suture and negative pressure wound therapy (NPWT) closure of the wound could help obtain excellent to good functional outcomes with fewer complications. This novel incision management approach and concept expands the surgical indications for these fractures.
C1 [Zhang, Yang; Zhao, Yangyang; Liu, Shuanggong; Yao, Zihan; Ma, Wanli] Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Orthopaed, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China.
   [Jin, Zikang] Linglong Yingcheng Hosp, Dept Orthopaed, Zhaoyuan 264000, Shandong, Peoples R China.
C3 Shandong University
RP Ma, WL (通讯作者)，Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Orthopaed, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China.
EM mawanli2000@email.sdu.edu.cn
RI yao, zihan/HCH-0912-2022
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NR 43
TC 1
Z9 1
U1 1
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 21
PY 2025
VL 15
IS 1
AR 2683
DI 10.1038/s41598-025-86125-5
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA T2A1D
UT WOS:001403090300008
PM 39837920
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ideguchi, Y
   Ono, S
   Kaneyuku, S
   Murakami, T
   Ogawa, R
AF Ideguchi, Yuki
   Ono, Shimpei
   Kaneyuku, Shintaro
   Murakami, Taishi
   Ogawa, Rei
TI Reconstruction Using Negative Pressure Wound Therapy with a Cotton
   Filler for Fixation of Male Genital Skin Grafts in Cases of Fournier's
   Gangrene
SO JOURNAL OF NIPPON MEDICAL SCHOOL
LA English
DT Article
DE cotton filler; gauze based; negative pressure wound therapy; skin graft;
   genitalia
AB The reliable engraftment of skin grafts into areas with complex shapes can be challenging. Here, we report a case of successful fixation of a genital skin graft using negative pressure wound therapy (NPWT) with RENASYS (R) Cotton Filler. A 44-year-old male with no relevant medical history underwent split- thickness skin grafting for a genital skin defect caused by Fournier's gangrene. A 0.4-mm sheet graft was applied for the penile skin defect, while 0.4-mm 1.5 times mesh grafting was applied for the testis and spermatic cord. NPWT with a cotton filler was used for seven days of fixation. No postoperative pain or stool contamination was observed. Although a small area of partial necrosis developed, the lesion healed with conservative treatment. Six months after surgery, there was no scar contracture, urination disorder, or pain during erection. Cotton fillers are highly malleable and adaptable, allowing for simple and reliable fixation of skin grafts in complex areas. Moreover, NPWT for genital graft fixation avoids contamination from stools. Therefore, we recommend fixation using NPWT with a cotton filler for genital skin grafting. (J Nippon Med Sch 2024; 91: 595 & horbar;599)
C1 [Ideguchi, Yuki; Kaneyuku, Shintaro; Murakami, Taishi] Aidu Chuo Hosp, Dept Plast Surg, 11 Tsurugamachi, Aizu Wakamatsu, Fukushima 9650011, Japan.
   [Ono, Shimpei; Ogawa, Rei] Nippon Med Coll Hosp, Dept Plast Reconstruct & Aesthet Surg, Tokyo, Japan.
C3 Nippon Medical School
RP Ideguchi, Y (通讯作者)，Aidu Chuo Hosp, Dept Plast Surg, 11 Tsurugamachi, Aizu Wakamatsu, Fukushima 9650011, Japan.
EM ideguchiyuki121@gmail.com
CR Akcan A, 2009, ULUS TRAVMA ACIL CER, V15, P342
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NR 19
TC 1
Z9 1
U1 0
U2 1
PU MEDICAL ASSOC NIPPON MEDICAL SCH
PI TOKYO
PA 1-1-5, SENDAGI, TOKYO, 113-8602, JAPAN
SN 1345-4676
EI 1347-3409
J9 J NIPPON MED SCH
JI J. Nippon Med. Sch.
PD DEC
PY 2024
VL 91
IS 6
BP 595
EP 599
DI 10.1272/jnms.JNMS.2024_91-610
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA T2I0A
UT WOS:001403296700013
PM 39756950
OA Green Published, gold
DA 2026-07-24
ER
PT J
AU Woldesenbet, A
   Mcginley, C
   Fossett, D
AF Woldesenbet, Amanuel
   Mcginley, Christopher
   Fossett, Damirez
TI Negative Pressure Wound Therapy: An Analysis of Its Effectiveness on the
   Reduction of Postoperative Infection in Posterior Spine Surgery
SO WORLD NEUROSURGERY
LA English
DT Article
DE Comorbidity; Negative pressure; Posterior approach; Postoperative
   infections; Prevena; Spinal surgical site infections; Thoracolumbar
ID SURGICAL SITE INFECTION; RISK-FACTORS; PREVENTION; FUSION; INCISIONS;
   RATES
AB BACKGROUND: Negative pressure wound therapy (NPWT) has been used for postsurgical wound management across various disciplines, including spinal surgery. However, its efficacy in reducing wound infection rates after posterior thoracolumbar spine surgery remains uncertain. METHODS: A retrospective review was conducted at a single institution, examining 266 patients who underwent posterior thoracic, lumbar, or thoracolumbar spine surgery performed by 1 neurosurgeon. Data included NPWT usage, type of surgery, infection rates, prior spinal surgeries, demographics, comorbidities, smoking status, and immune profiles. Statistical analysis was performed to evaluate correlations. RESULTS: Of the 266 patients, 122 (46%) were males, 144 (54%) were females, and 213 (80%) were Black. Patients had a mean age of 56.4 years and an average body mass index of 29.6 kg/m(2). NPWT was applied to 153 patients (57.5%). Postoperative wound infections occurred in 35 patients (13%), with 19 (54%) in the NPWT group. Overall, NPWT use was not associated with a statistically significant reduction in infection rates (P = 0.69). However, analysis of patients with multiple comorbidities showed a significant decrease in infections with NPWT (P< 0.01). A total of 198 patients (74.4%) had at least 1 comorbidity, and 10.1% (n = 20) had 2 or more major comorbidities. CONCLUSIONS: NPWT significantly reduced infection rates in patients with multiple comorbidities, suggesting its potential benefit in managing wound infections in this subgroup. This finding is particularly relevant for an urban, minority patient population, highlighting the importance of tailored wound care strategies.
C1 [Woldesenbet, Amanuel; Mcginley, Christopher] HOWARD UNIV, Coll Med, Dept Neurosurg, WASHINGTON, DC 20059 USA.
   [Fossett, Damirez] Howard Univ Hosp, Dept Surg, Div Neurosurg, Washington, DC USA.
C3 Howard University; Howard University
RP Woldesenbet, A (通讯作者)，HOWARD UNIV, Coll Med, Dept Neurosurg, WASHINGTON, DC 20059 USA.
EM W.amanuel94@gmail.com
OI McGinley, Christopher/0009-0003-2533-1068
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NR 32
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD FEB
PY 2025
VL 194
AR 123591
DI 10.1016/j.wneu.2024.123591
EA JAN 2025
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA T3U0Q
UT WOS:001404287300001
PM 39725287
OA hybrid
DA 2026-07-24
ER
PT J
AU Cebolla-Verdugo, M
   de Cádiz, VACG
   Velasco-Amador, JP
   Zulaika-Lloret, M
   Almazan-Fernández, FM
   Ruiz-Villaverde, R
AF Cebolla-Verdugo, Marta
   Cassini-Gomez de Cadiz, Victor Alfredo
   Velasco-Amador, Juan Pablo
   Zulaika-Lloret, Maria
   Almazan-Fernandez, Francisco Manuel
   Ruiz-Villaverde, Ricardo
TI Multidisciplinary Vulvar Cancer Management: The Dermatologist's
   Perspective
SO LIFE-BASEL
LA English
DT Review
DE vulvar cancer; squamous cell carcinoma (SCC); vulvar melanoma;
   dermatologist; radical vulvectomy; postoperative care; wound management;
   multidisciplinary approach; targeted therapies
ID SURGICAL-TREATMENT; RISK-FACTORS; INTRAEPITHELIAL NEOPLASIA; TARGETED
   THERAPY; MELANOMA; COMPLICATIONS; RECONSTRUCTION; CARCINOMA; SURGERY;
   LYMPHADENECTOMY
AB Vulvar cancer, particularly squamous cell carcinoma (SCC) and melanoma, poses significant diagnostic and therapeutic challenges due to its complex presentation and high rates of postoperative complications. Effective management requires a multidisciplinary approach, integrating the expertise of gynecologic oncologists, dermatologists, plastic surgeons, and other specialists. This review highlights the dermatologist's role in supporting early diagnosis, addressing predisposing conditions such as lichen sclerosus, and managing postoperative wound complications, including surgical site infections and dehiscence. Through two clinical cases, we illustrate how dermatological expertise complements surgical efforts by employing advanced wound care techniques such as negative pressure wound therapy and tailored dressing protocols. By collaborating closely with gynecologists and other team members, dermatologists enhance patient outcomes, ensuring timely recovery and the prevention of long-term sequelae. The article also discusses recent advances in treatment guidelines and targeted therapies, underscoring the importance of integrated care for optimizing patient outcomes in vulvar cancer.
C1 [Cebolla-Verdugo, Marta; Cassini-Gomez de Cadiz, Victor Alfredo; Velasco-Amador, Juan Pablo; Zulaika-Lloret, Maria; Almazan-Fernandez, Francisco Manuel; Ruiz-Villaverde, Ricardo] Hosp Univ San Cecilio, Dept Dermatol, Ave Conocimiento S-N, Granada 18016, Spain.
   [Cebolla-Verdugo, Marta; Cassini-Gomez de Cadiz, Victor Alfredo; Velasco-Amador, Juan Pablo; Zulaika-Lloret, Maria; Almazan-Fernandez, Francisco Manuel; Ruiz-Villaverde, Ricardo] Inst Biosanitario Granada, Ibs, Granada 18012, Spain.
C3 Hospital Universitario San Cecilio; Instituto de Investigacion
   Biosanitaria IBS Granada
RP Cebolla-Verdugo, M (通讯作者)，Hosp Univ San Cecilio, Dept Dermatol, Ave Conocimiento S-N, Granada 18016, Spain.; Cebolla-Verdugo, M (通讯作者)，Inst Biosanitario Granada, Ibs, Granada 18012, Spain.
EM martacevers@gmail.com; elromeral28a@gmail.com; pablova.correo@gmail.com;
   zulaikalloretmaria@gmail.com; almazanweb@gmail.com;
   ismenios2005@gmail.com
RI ; Cebolla Verdugo, Marta/JHS-4101-2023; Ruiz-Villaverde,
   Ricardo/F-5007-2016
OI Zulaika Lloret, María/0009-0008-5865-410X; Cebolla Verdugo,
   Marta/0000-0001-7519-205X; Ruiz-Villaverde, Ricardo/0000-0002-0381-6174
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NR 58
TC 3
Z9 3
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JAN
PY 2025
VL 15
IS 1
AR 19
DI 10.3390/life15010019
PG 13
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA T6H3W
UT WOS:001405987300001
PM 39859956
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gijón, MM
   Sánchez, AS
   Alvarez, ID
   Miravalles, JLR
   Pais, SA
   Uría, RR
   Navarro, SS
   Vico, TD
   Santos, ET
   Alvarez, LS
AF Gijon, Maria Moreno
   Sanchez, Aida Suarez
   Alvarez, Irene de Santiago
   Miravalles, Jose Luis Rodicio
   Pais, Sonia Amoza
   Uria, Raquel Rodriguez
   Navarro, Sandra Sanz
   Vico, Tamara Diaz
   Santos, Estrella Turienzo
   Alvarez, Lourdes Sanz
TI The efficacy of negative-pressure wound therapy (NPWT) in the prevention
   of surgical site occurrences in open abdominal surgery: A randomized
   clinical trial
SO SURGERY
LA English
DT Article
ID CARE-ASSOCIATED INFECTIONS; METAANALYSIS; COSTS
AB Background: The secondary consequences of surgical site occurrences, especially surgical site infections, worsen the patient's outcomes while significantly increasing health care costs. The implementation of preventive measures to reduce this complication rate should be one of the priorities to improve health care. Methods: A randomized, open-label clinical trial was conducted between March 2019 and March 2021 in a general surgery department. Individuals who had undergone laparotomy and had risk factors for developing surgical site infections and surgical site occurrences were included and randomized to use either negative-pressure wound therapy or conventional dressing (control group) on the closed surgical incision. The aim of our study was to evaluate the benefit of negative-pressure wound therapy in the surgical site infection rates and other surgical site occurrences in both groups at a 30-day follow-up. Results: Two hundred seventy-five participants were recruited and were analyzed, 147 (53.5%) in the negative-pressure wound therapy group and 128 (46.5%) in the control group. Thirty-one (11.3%) surgical site infections and 71 (25.8%) other surgical site occurrences were observed, being significantly lower in the negative-pressure wound therapy group (odds ratio 0.31, 95% confidence interval 0.14-0.71; P = .005) and (odds ratio 0.51, 95% confidence interval 0.29-0.90; P = .02), respectively. Absolute risk reduction was 13% for surgical site infection and 12% for other surgical site occurrences. Number needed to treat 9 (95% confidence interval 5-29) for surgical site infection and number needed to treat of 8 (95% confidence interval 5-51) for other surgical site occurrences. Median hospital stay was 3 days lower in the negative-pressure wound therapy group than in the control group (9 vs 12 days; P = .03). No severe adverse events attributable to the negative-pressure wound therapy dressing were reported. Conclusion: Negative-pressure wound therapy decreases the risk of surgical site occurrences and surgical site infection after laparotomy, so that its use should be considered in patients with risk factors. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Gijon, Maria Moreno; Sanchez, Aida Suarez; Miravalles, Jose Luis Rodicio; Pais, Sonia Amoza; Uria, Raquel Rodriguez; Navarro, Sandra Sanz; Santos, Estrella Turienzo; Alvarez, Lourdes Sanz] Asturias Cent Univ Hosp HUCA, Gen Surg Dept, Oviedo, Spain.
   [Gijon, Maria Moreno; Sanchez, Aida Suarez; Miravalles, Jose Luis Rodicio; Pais, Sonia Amoza; Uria, Raquel Rodriguez; Navarro, Sandra Sanz; Santos, Estrella Turienzo; Alvarez, Lourdes Sanz] Hlth Res Inst Principal Asturias ISPA, Oviedo, Spain.
   [Alvarez, Irene de Santiago] San Agustin Hosp, Gen Surg Dept, Aviles, Spain.
   [Vico, Tamara Diaz] Rey Juan Carlos Univ Hosp, Gen Surg Dept, Madrid, Spain.
C3 Central University Hospital Asturias; Instituto de Investigacion
   Sanitaria del Principado de Asturias (ISPA)
RP Gijón, MM (通讯作者)，Hosp Univ Cent Asturias HUCA, Gen Surg Dept, Ave Roma S-N, Oviedo, Asturias, Spain.
EM mmorensue@gmail.com
RI ; Díaz Vico, Tamara/AAU-4374-2021
OI Moreno Gijón, María/0000-0003-2328-9874; Rodicio Miravalles, Jose
   Luis/0000-0002-3223-6128; Díaz Vico, Tamara/0000-0002-4084-0501
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NR 39
TC 6
Z9 7
U1 1
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD FEB
PY 2025
VL 178
AR 108920
DI 10.1016/j.surg.2024.10.011
EA JAN 2025
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA T7Z0T
UT WOS:001407128700001
PM 39613656
DA 2026-07-24
ER
PT J
AU Sailer, M
   Wergeland, H
   Randsborg, PH
AF Sailer, Monica
   Wergeland, Hilde
   Randsborg, Per-Henrik
TI Implementation of a clinical pathway for diabetes-related foot ulcers
   reduced the number of amputations and shortened hospital stay
SO JOURNAL OF FOOT AND ANKLE RESEARCH
LA English
DT Article
DE diabetic foot ulcer; negative pressure wound therapy; treatment
   algorithm; vacuum assisted closure; wound care
ID LOWER-EXTREMITY AMPUTATION; PRESSURE WOUND THERAPY; MORTALITY
AB Introduction: Diabetes-related foot ulcer (DFU) is the leading cause for lower extremity amputations (LEAs) in western countries, and may cause social isolation, depression, and death. However, people with DFU are not offered the same prioritized care as cancer patients, despite comparable mortality rates. We therefore decided to create a clinical pathway for patients with DFU. The purpose of this study is to evaluate the efficacy of implementing a new clinical pathway on rates of LEA, length of hospital stays, and cost reduction. Methods: On January 1, 2019, a new clinical pathway ensured that all patients with a DFU were evaluated in a designated clinic run by a foot and ankle orthopedic surgeon in collaboration with the vascular surgeons, supported by a specialized wound nurse and a certified prosthetist/orthotist (CPO). We designed an algorithm for the first consultation to identify patients in need for further investigation by other specialties such as endocrinology, infectious diseases, cardiology, or vascular surgery. All patients underwent a surgical wound debridement of DFU. Negative pressure wound therapy (NPWT) was not applied. After surgery, the dressings were changed daily on the ward, until the wound was deemed viable and clean. The patients were followed for two years and compared to a historic cohort of patients with DFU admitted to the institution in 2017. Results: The number of major amputations was reduced from 65% (13/20) to 7.4% (2/27) (p < 0.001) after the introduction of the clinical pathway. Both the mean number of surgical revisions (5.5 vs. 1.2) and the median length of stay (46 vs. 9 days) were statistically significantly reduced. The median cost per patient was reduced by 76% (from <euro>538 000 to <euro>129 000, p < 0.001). Conclusion: The clinical pathway for managing DFUs resulted in a reduction in major amputations and shorter hospital stays. Discontinuing NPWT after surgical debridement did not adversely affect clinical outcomes. The new pathway also contributed to lower healthcare costs.
C1 [Sailer, Monica; Randsborg, Per-Henrik] Akershus Univ Hosp, Dept Orthopaed Surg, N-1478 Lorenskog, Norway.
   [Sailer, Monica; Randsborg, Per-Henrik] Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway.
   [Wergeland, Hilde] Akershus Univ Hosp, Dept Econ & Finance, Lorenskog, Norway.
C3 University of Oslo; University of Oslo; University of Oslo
RP Sailer, M (通讯作者)，Akershus Univ Hosp, Dept Orthopaed Surg, N-1478 Lorenskog, Norway.
EM monica_sailer@yahoo.no
RI Randsborg, Per-Henrik/X-5280-2019
OI Randsborg, Per-Henrik/0000-0002-7674-1572; Sailer,
   Monica/0000-0002-1022-7845; Wergeland, Hilde/0009-0008-0936-4165
FU South-Eastern Norway Regional Health Authority
FX The authors wish to thank Johanna Austeen Gjestland for navigating us
   safely through formalities and red tape.
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NR 25
TC 4
Z9 4
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1757-1146
J9 J FOOT ANKLE RES
JI J. Foot Ankle Res.
PD JAN 28
PY 2025
VL 18
IS 1
AR e70024
DI 10.1002/jfa2.70024
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA U0I2W
UT WOS:001408728900001
PM 39875339
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Choi, D
   Cho, WT
   Song, HK
   Kwon, J
   Kang, BH
   Jung, H
   Kim, MJ
   Jung, K
AF Choi, Donghwan
   Cho, Won Tae
   Song, Hyung Keun
   Kwon, Junsik
   Kang, Byung Hee
   Jung, Hohyung
   Kim, Min Ji
   Jung, Kyoungwon
TI Conventional versus Instillation Negative-Pressure Wound Therapy for
   Severe Soft Tissue Injury in Open Pelvic Fractures: A Retrospective
   Review
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE Negative-pressure wound therapy; instillation; open fractures; pelvis;
   soft tissue infection; wound healing
ID ASSISTED CLOSURE VAC(TM); CARE; MANAGEMENT; MORTALITY; SEPSIS
AB Purpose: We investigated the clinical features, current negative-pressure wound therapy (NPWT) management strategies, and outcomes of pelvic-perineal soft tissue infection after open pelvic fractures. Materials and Methods: We analyzed the data of patients admitted to our trauma center with pelvic-perineal soft tissue after open pelvic fractures over a 7-year period. We investigated the injury severity score (ISS), medical costs, number of NPWTs, time required to reach definite wound coverage, complications, fracture classifications, transfusion requirements, interventions, length of stay (LOS) in hospital and intensive care unit (ICU), and prognosis. Results: Twenty patients with open pelvic fractures were treated with NPWT, and one patient who underwent NPWT died of pelvic sepsis during ICU treatment. The median LOS in hospital and medical costs were 98 [56-164] days and 106400 [65600-171100] USD, respectively. Patients treated with instillation NPWT (iNPWT, n=10) had a shorter NPWT duration (24 [13-39] vs. 46 [42-91] days, p=0.023), time to definite wound coverage (30 [21-43] vs. 49 [42-93] days, p=0.026), and hospital LOS (56 [43-72] vs. 158 [101-192] days, p=0.001), as well as lower medical costs (67800 [42500-102500] vs. 144200 [110400-236000] USD, p=0.009) compared to those treated with conventional NPWT. Conclusion: NPWT is a feasible method for treating pelvic soft tissue infections in patients with open pelvic fractures. iNPWT can reduce the duration of NPWT, hospital LOS, and medical costs.
C1 [Choi, Donghwan; Kwon, Junsik; Kang, Byung Hee; Jung, Hohyung; Jung, Kyoungwon] Ajou Univ, Sch Med, Dept Surg, Div Trauma Surg, 164 Worldcup Ro, Suwon 16499, South Korea.
   [Cho, Won Tae; Song, Hyung Keun] Ajou Univ, Sch Med, Dept Orthoped Surg, Suwon, South Korea.
   [Kim, Min Ji] Ajou Univ, Dept Plast Surg, Sch Med, Dept Surg, Suwon, South Korea.
C3 Ajou University; Ajou University; Ajou University
RP Jung, K (通讯作者)，Ajou Univ, Sch Med, Dept Surg, Div Trauma Surg, 164 Worldcup Ro, Suwon 16499, South Korea.
EM jake98@daum.net
RI Kwon, Junsik/AAE-3143-2022; Choi, Donghwan/JXN-6996-2024
OI Kwon, Junsik/0000-0003-3164-4995; Choi, Donghwan/0000-0001-7596-4371;
   Cho, Won-Tae/0000-0002-9764-3912; Kim, Min Ji/0000-0002-0723-4382; Jung,
   Hohyung/0000-0002-5536-5483; Kang, Byung Hee/0000-0003-3204-3251; Song,
   Hyung Keun/0000-0001-5486-2560
CR Anchalia Manjulata, 2020, Wounds, V32, pE84
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD FEB
PY 2025
VL 66
IS 2
BP 94
EP 102
DI 10.3349/ymj.2023.0473
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA U1G1U
UT WOS:001409352900004
PM 39894042
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mackeen, AD
   Sullivan, M
   Berghella, V
AF Mackeen, Awathif Dhanya
   Sullivan, Maranda, V
   Berghella, Vincenzo
TI Evidence-based cesarean delivery: intraoperative management following
   placental delivery until skin closure (part 9)
SO AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
LA English
DT Article
DE abdominal closure; cesarean; intraoperative; meta-analysis; randomized
   controlled trials; skin closure; systematic review; technique; uterine
   closure
ID DOUBLE-LAYER CLOSURE; WOUND COMPLICATIONS; UTERINE INCISION; SECTION;
   PERITONEUM; OUTCOMES; IRRIGATION; TRIAL; NONCLOSURE; PREVENTION
AB This expert review provides recommendations for the cesarean delivery technique after placental delivery to skin closure. After placental delivery sponge curettage may be omitted as it has not been shown to decrease the risk of retained products of conception. Uterine irrigation and mechanical cervical dilation cannot be recommended. Either intra-abdominal or extra-abdominal repair of the hysterotomy is acceptable, with some possible benefits, such as decreased postoperative pain and nausea/vomiting with intra-abdominal repair. There is insufficient evidence to recommend one uterine closure technique over the other with regards to suture type, continuous versus interrupted, locking or non-locking, and one versus two-layer closure. Double-layer uterine closure has been shown to be more beneficial with regards to residual myometrial thickness, and full thickness bites (including the endometrium) should be considered. Glove change by the surgical team is recommended after placental delivery and before closure of the abdominal wall. The following techniques are not recommended: intra-abdominal irrigation, use of adhesion prevention barriers, peritoneal closure, and rectus muscle reapproximation. Based on non-cesarean delivery evidence, fascial closure bites should be at least 5 x 5 mm, with monofilament suture for vertical incisions. As an adjunct to postoperative pain control, surgeons may consider wound infiltration with local anesthesia, either supra- or subfascial. Before closure, subcutaneous irrigation may be performed using saline solution, and routine use of subcutaneous drains is not recommended. Although closure of the subcutaneous layer can be considered in all patients, it should occur when the depth is >= 2 cm. A monofilament absorbable suture, such as poliglecaprone, should be used to close the cesarean skin incision. There is no level 1 evidence evaluating the potential benefit of additional skin adhesive or sterile strips after suture skin closure. If a dressing is preferred over the skin incision, the following approaches may be considered: a dialkylcarbamoyl chloride-impregnated dressing if available or a standard gauze dressing is appropriate. Prophylactic negative pressure wound therapy can be considered in patients with obesity. Vaginal seeding during cesarean delivery is not recommended. El resumen esta disponible en Espanol al final del art & iacute;culo.
C1 [Berghella, Vincenzo] Geisinger, Womens Hlth Serv Line, Div Maternal Fetal Med, Danville, PA 17821 USA.
   Thomas Jefferson Univ, Dept Obstet & Gynecol, Div Maternal Fetal Med, Philadelphia, PA USA.
C3 Thomas Jefferson University
RP Berghella, V (通讯作者)，Geisinger, Womens Hlth Serv Line, Div Maternal Fetal Med, Danville, PA 17821 USA.
EM vincenzo.berghella@jefferson.edu
RI Berghella, Vincenzo/K-8634-2018
OI , Maranda/0000-0003-0191-1909; Mackeen, A. Dhanya/0000-0002-7398-2063
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NR 84
TC 5
Z9 5
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2589-9333
J9 AM J OBST GYNEC MFM
JI Amer. J. Obstet. Gynecol. MFM
PD JAN
PY 2025
VL 7
IS 1
AR 101548
DI 10.1016/j.ajogmf.2024.101548
EA JAN 2025
PG 16
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA U2U9R
UT WOS:001410418400001
PM 39547444
DA 2026-07-24
ER
PT J
AU Adegboye, O
   Pillay, K
   Adams, S
AF Adegboye, Oluwatobi
   Pillay, Kamlen
   Adams, Saleigh
TI Acellular Dermal Matrices in Reconstructive Pediatric Complex Lower Limb
   Trauma: An Observational Study
SO JOURNAL OF TRAUMA NURSING
LA English
DT Article
DE Acellular dermal matrices (ADMs); Lower limb trauma; Negative pressure
   wound therapy (NPWTs); Observational study; Pediatric trauma;
   Retrospective study; Trauma complications
ID PRESSURE WOUND THERAPY; MANAGEMENT; COVERAGE; FLAPS
AB BACKGROUND:Contemporary research has shown that acellular dermal matrices can benefit adult lower extremity traumatic injuries; however, its use in children has not been explored.OBJECTIVE:This study aims to explore the use of acellular dermal matrices in pediatric complex lower extremity trauma.METHODS:This single-center retrospective observational cohort study of children with complex lower extremity trauma treated with Pelnac (TM), commercial acellular dermal matrices, was conducted at a tertiary hospital in South Africa from 2010 to 2017. Demographic and clinical data were collected from medical records. The primary outcome was the rate and type of acellular dermal matrices-related complications. Secondary outcomes included the usage of negative pressure wound therapy.RESULTS:A total of 54 children were studied; 30 (55%) were male, and the median age was six. Forty-five children healed without complications, while nine experienced complications - four acute and five chronic. Four patients had complete loss of acellular dermal matrices, and three developed acute infections. More than 30 days post-acellular dermal matrices application, five patients had hypertrophic scarring, four had joint contractures, and two had non-healing wounds. All patients who healed without complication received negative pressure wound therapy (n = 45), while those who did not (n = 5) developed complications. Three of the five patients without negative pressure wound therapy had acute acellular dermal matrices loss, compared to only one of the 49 patients who received negative pressure wound therapy.CONCLUSION:Our findings suggest that acellular dermal matrices may be an effective and safe reconstructive adjunct or alternative when used with negative pressure wound therapy.
C1 [Adegboye, Oluwatobi] Anglia Ruskin Univ, Fac Hlth Educ Med & Social Care, St Andrews Anglia Ruskin StAAR Res Grp, Chelmsford, England.
   [Pillay, Kamlen; Adams, Saleigh] Red Cross War Mem Childrens Hosp, Div Plast & Reconstruct Surg, Cape Town, South Africa.
   [Pillay, Kamlen; Adams, Saleigh] Univ Cape Town, Groote Schuur Hosp, Div Plast & Reconstruct Surg, Cape Town, South Africa.
C3 Anglia Ruskin University; University of Cape Town
RP Adegboye, O (通讯作者)，Broomfield Hosp, St Andrews Anglia Ruskin Res Grp StAAR, Chelmsford CM1 7ET, England.; Adegboye, O (通讯作者)，Broomfield Hosp, St Andrews Ctr Plast Surg & Burns, Chelmsford CM1 7ET, England.
EM oa34@aru.ac.uk; drpillay@scinmed.com; saleigh.adams@uct.ac.za
RI Ada, Saleigh/AGI-8895-2022; Adegboye, Oluwatobi/KOC-8212-2024
OI Ada, Saleigh/0000-0002-0552-9400; Adegboye,
   Oluwatobi/0000-0003-1659-9444
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NR 43
TC 0
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1078-7496
EI 1932-3883
J9 J TRAUMA NURS
JI J. Trauma Nurs.
PD JAN-FEB
PY 2025
VL 32
IS 1
BP 23
EP 29
DI 10.1097/JTN.0000000000000829
PG 7
WC Critical Care Medicine; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Nursing
GA U3L5A
UT WOS:001410848700003
PM 39879269
DA 2026-07-24
ER
PT J
AU Chang, S
   Wang, Y
   Zhang, ZS
AF Chang, Sheng
   Wang, Yu
   Zhang, Zengshan
TI Impact of VSD therapy on surgical outcomes, inflammatory markers, and
   functional rehabilitation in patients with secondary bone infection
   following tibial fracture surgery
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE VSD; bone infection secondary to tibial fracture; distribution of
   pathogenic bacteria; inflammatory factors; bone infection
AB Objective: The aim of this study was to investigate the effect of vacuum sealing drainage (VSD) treatment on surgical indicators, inflammatory factors, and functional recovery in patients with chronic osteomyelitis secondary to open tibial fractures. Methods: In total, 87 patients with secondary bone infection after internal fixation of tibial fracture treated in the Affiliated Hospital of Shandong Second Medical University from December 2020 to June 2022 were selected, all of whom were tibial shaft fractures. Of these, 55 cases of primary open fracture were sutured in the first stage; 32 cases underwent internal fixation after primary debridement at the time of trauma. The patients were treated with surgical debridement, removal of internal fixation, and fixation with an external fixation frame. After debridement, those with local wounds that could not be completely closed and were complicated with exposed bone were randomly selected for either VSD covering treatment (study group, n=46) or bone cement covering treatment (control group, n=41. The distribution of pathogenic bacteria, surgical indicators, inflammatory factors [tumor necrosis factor & hybull;alpha(TNF & hybull;alpha), interleukin & hybull;6 (IL & hybull;6), and C & hybull;reactive protein (CRP) levels], functional recovery [knee, ankle, and limb function recovery], and complications were summarized. Results: There were 87 pathogenic bacteria strains in 87 patients, including 43 Gram & hybull;positive bacteria strains (49.42%), 32 Gram & hybull;negative bacteria strains (36.78%), and 12 fungi strains (13.80%). The number of dressing changes in the study group was less than that in the control group. The infection control time, wound sterility time, hospitalization time, and skin flap transfer operation time in the study group were shorter than those in the control group and the difference was statistically significant (P<0.05). After treatment, the levels of TNF & hybull;alpha, IL & hybull;6, and CRP in the two groups decreased, among which the change in the study group was the most significant and the difference between the two groups was statistically significant (P<0.05). After treatment, the Hospital for Special Surgery Knee Score and Baird-Jackson score of the two groups increased, among which the change in the study group was the most significant and the difference between the two groups was statistically significant (P<0.05). The excellent and good rate of the study group (95.65%) was higher than the excellent and good rate of the control group (80.49%) and the difference was statistically significant (P<0.05). Conclusion: When a wound cannot be closed, VSD treatment of patients with secondary bone infection after internal fixation of tibial fracture can improve the level of surgical indicators and inflammatory factor levels in patients, and promote the recovery of patients' limb function, and is thus worthy of clinical promotion and application.
C1 [Chang, Sheng] Heze Municipal Hosp, Dept Spine Surg, Heze, Peoples R China.
   [Wang, Yu] Qingdao Univ, Dept Anesthesiol, Womens & Childrens Hosp, Qingdao, Peoples R China.
   [Zhang, Zengshan] Shandong Second Med Univ, Affiliated Hosp, Dept Orthoped, Weifang, Peoples R China.
C3 Qingdao University; Shandong Second Medical University
RP Zhang, ZS (通讯作者)，Shandong Second Med Univ, Affiliated Hosp, Dept Orthoped, Weifang, Peoples R China.
EM zengshan1003@163.com
CR Chastain DB, 2019, INT J ANTIMICROB AG, V53, P429, DOI 10.1016/j.ijantimicag.2018.11.023
   Christersson A, 2018, EJNMMI RES, V8, DOI 10.1186/s13550-018-0426-0
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   Li Y, 2018, J MUSCULOSKEL NEURON, V18, P272
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NR 13
TC 1
Z9 1
U1 1
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD JAN 17
PY 2025
VL 14
AR 1508424
DI 10.3389/fcimb.2024.1508424
PG 6
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA U3R0A
UT WOS:001410994000001
PM 39897483
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Atherton, K
   SUNRRISE Trial Study Grp
   Brown, J
   Clouston, H
   Coe, P
   Duarte, R
   Dudi-Venkata, NN
   Duff, S
   Egoroff, N
   Fish, R
   Glasbey, J
   Ives, N
   Kaur, M
   Magill, L
   Mehta, S
   Pinkney, T
   Pockney, P
   Richards, T
   Sammour, T
   Sekhar, H
   Sinha, Y
   Stott, M
   Wilkin, R
AF Atherton, Kristy
   SUNRRISE Trial Study Group, James
   Brown, James
   Clouston, Hamish
   Coe, Pete
   Duarte, Rui
   Dudi-Venkata, Nagendra N.
   Duff, Sarah
   Egoroff, Natasha
   Fish, Rebecca
   Glasbey, James
   Ives, Natalie
   Kaur, Manjinder
   Magill, Laura
   Mehta, Samir
   Pinkney, Thomas
   Pockney, Peter
   Richards, Toby
   Sammour, Tarik
   Sekhar, Hema
   Sinha, Yash
   Stott, Martyn
   Wilkin, Richard
TI Negative Pressure Dressings to Prevent Surgical Site Infection After
   Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID CESAREAN DELIVERY; IMPACT; CARE
AB Importance Patients undergoing unplanned abdominal surgical procedures are at increased risk of surgical site infection (SSI). It is not known if incisional negative pressure wound therapy (iNPWT) can reduce SSI rates in this setting. Objective To evaluate the effectiveness of iNPWT in reducing the rate of SSI in adults undergoing emergency laparotomy with primary skin closure. Design, Setting, and Participants SUNRRISE was an assessor-masked, pragmatic, phase 3, individual-participant, randomized clinical trial. Adult patients undergoing emergency laparotomy in 22 hospitals in the UK and 12 hospitals in Australia between December 18, 2018, and May 25, 2021, were recruited. Patients were followed up for 30 days postprocedure; database closure was on August 25, 2021. Interventions Participants were randomized 1:1 to receive iNPWT (n = 411), which involved a specialized dressing used to create negative pressure over the closed wound vs the surgeon's choice of wound dressing (n = 410). Randomization and dressing application occurred in the operating room at the end of the surgical procedure. Main Outcomes and MeasuresThe primary outcome measure was SSI up to 30 days postprocedure, evaluated by an assessor masked to the randomized allocation and using criteria from the US Centers for Disease Control and Prevention. There were 7 secondary outcomes, including length of hospital stay, postoperative complications up to 30 days, hospital readmission for wound-related complications within 30 days, wound pain, and quality of life. Results A total of 840 patients were randomized (536 from the UK; 304 from Australia). Overall, 52% were female; the mean age was 63.8 (range, 18.8 to 95.3) years. After postrandomization exclusions (N = 52), 394 participants per group were included in the primary analysis. The number of participants who had an SSI in the iNPWT group was 112 of 394 (28.4%), compared with 108 of 394 (27.4%) in the surgeon's preference group (relative risk, 1.03 [95% CI, 0.83-1.28]; P = .78). This finding was consistent across the preplanned subgroup analyses, including degree of contamination, presence of a stoma, participant body mass index, and skin preparation used, and across all preplanned sensitivity analyses. Of 7 secondary outcomes, 6 showed no significant difference, including hospital readmission, quality of life, and hospital stay (median [IQR], 8 [6-14] days in the iNPWT group and 9 [6-14.5] days in the surgeon's preference group [ratio of geometric means, 0.96 (95% CI, 0.88-1.06); P = .21]). Conclusions and Relevance Routine application of iNPWT to the closed surgical wound after emergency laparotomy did not prevent SSI more than other dressings. Trial Registrationisrctn.com Identifier: ISRCTN17599457; anzctr.org.au Identifier: ACTRN12619000496112
C1 [Atherton, Kristy; Egoroff, Natasha; Pockney, Peter] Univ Newcastle, Sydney, Australia.
   [Brown, James; Glasbey, James; Ives, Natalie; Kaur, Manjinder; Magill, Laura; Mehta, Samir; Pinkney, Thomas; Sinha, Yash] Univ Birmingham, Birmingham, England.
   [Clouston, Hamish; Fish, Rebecca; Sekhar, Hema] Christie NHS Fdn Trust, Manchester, England.
   [Coe, Pete] Leeds Teaching Hosp NHS Trust, Leeds, England.
   [Duarte, Rui; Stott, Martyn] Univ Liverpool, Liverpool, England.
   [Dudi-Venkata, Nagendra N.] Launceston Gen Hosp, Launceston, Tas, Australia.
   [Duff, Sarah] South Manchester Univ Hosp NHS Trust, Manchester, England.
   [Richards, Toby] UCL, London, England.
   [Sammour, Tarik] Univ Adelaide, Adelaide, Australia.
   [Wilkin, Richard] Worcestershire Royal Hosp, Worcester, England.
C3 University of Newcastle; University of Birmingham; Christie NHS
   Foundation Trust; University of Leeds; University of Liverpool;
   Launceston General Hospital; Wythenshawe Hospital NHS Foundation Trust;
   University of London; University College London; Adelaide University;
   University of Adelaide
RP Mehta, S (通讯作者)，Univ Birmingham, Coll Med & Hlth, Birmingham Clin Trials Unit, Birmingham B15 2TT, England.
EM s.mehta.1@bham.ac.uk
RI Sammour, Tarik/H-3467-2019; Dudi-Venkata, Nagendra/AAR-9204-2020;
   Duarte, Rui/C-9635-2012; Atherton, Kristy/JHU-9380-2023; Glasbey,
   James/I-2457-2019; Pinkney, Thomas/HGA-4022-2022; Stott,
   Martyn/ACR-2481-2022; Fish, Rebecca/L-2954-2019; Richards,
   Toby/K-6547-2013
OI Sammour, Tarik/0000-0002-4918-8871; Dudi-Venkata,
   Nagendra/0000-0002-9775-3599; Magill, Laura/0000-0003-2498-8407; Sekhar,
   Hema/0000-0002-6384-8872; Glasbey, James/0000-0001-7688-5018; Brown,
   James/0000-0003-4513-1509; Ives, Natalie/0000-0002-1664-7541; Pinkney,
   Thomas/0000-0001-7320-6673; Stott, Martyn/0000-0002-3536-8281; 
FU National Institute for Health and Care Research (NIHR) Research for
   Patient Benefit Programme in the UK [PB-PG-0416-20045]; Medical Research
   Future Fund (MRFF) International Clinical Trials Collaboration Program
   in Australia [2019/MRF1179938]; National Institutes of Health Research
   (NIHR) [PB-PG-0416-20045] Funding Source: National Institutes of Health
   Research (NIHR)
FX SUNRRISE was investigator initiated and led. It was funded by the
   National Institute for Health and Care Research (NIHR) Research for
   Patient Benefit Programme (PB-PG-0416-20045) in the UK and the Medical
   Research Future Fund (MRFF) International Clinical Trials Collaboration
   Program (2019/MRF1179938) in Australia. PICO 7 dressings were provided
   free of charge by Smith & Nephew.
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NR 23
TC 18
Z9 21
U1 5
U2 13
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAR 11
PY 2025
VL 333
IS 10
BP 853
EP 863
DI 10.1001/jama.2024.24764
EA JAN 2025
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0DW5R
UT WOS:001411663500001
PM 39869330
OA Green Submitted, Green Accepted
DA 2026-07-24
ER
PT J
AU Gu, HY
   Zhao, XQ
   Sun, Y
   Ding, YY
   Rong, OY
AF Gu, Haiyun
   Zhao, Xiaoqin
   Sun, Yi
   Ding, Yiyi
   Rong, Ouyang
TI Negative-pressure wound therapy compared with advanced moist wound
   therapy: A comparative study on healing efficacy in diabetic foot ulcers
SO SURGERY
LA English
DT Article
ID MANAGEMENT; INSTILLATION; SURGERY; CARE
AB Objective: This randomized controlled trial aimed to compare the efficacy of negative-pressure wound therapy with advanced moist wound therapy in managing diabetic foot ulcers. Methods: A total of 450 participants with diabetic foot ulcers were randomized to receive either negative-pressure wound therapy (n = 204) or advanced moist wound therapy (n = 246) over 18 months. The primary outcome was complete ulcer closure, with secondary outcomes including time to closure, wound size reduction, infection rates, recurrence, and amputation rates. Wound dimensions were measured using digital planimetry, and Kaplan-Meier survival analysis was applied to assess time to closure. Result: Analysis revealed statistically significant differences in clinical outcomes between treatment modalities. In the negative-pressure wound therapy group (n = 204), complete ulcer closure was achieved in 177 patients (87%), which was significantly greater than the advanced moist wound therapy group (n = 246) with 72 patients (29%) (P < .001). Although the mean time to wound closure was marginally extended in the negative-pressure wound therapy group (73 +/- 45 days vs 64 +/- 49 days; P = .045), this cohort demonstrated substantially more significant wound area reduction (48% +/- 15 vs 25% +/- 30; P < .001). Secondary outcome analysis revealed that negative-pressure wound therapy was associated with markedly reduced adverse events: wound infection (40 patients [20%] vs 95 patients [39%]; P < .001), ulcer recurrence (40 patients [20%] vs 113 patients [46%]; P < .001), and amputation rates (30 patients [15%] vs 132 patients [54%]; P < .001). Longitudinal assessment through Kaplan-Meier survival analysis demonstrated significantly greater wound closure probability and reduced complication risk in the negative-pressure wound therapy group throughout the follow-up period (log-rank P < .001). Conclusion: Negative-pressure wound therapy is significantly more effective than advanced moist wound therapy in treating diabetic foot ulcers, demonstrating superior outcomes in wound closure, infection control, and amputation prevention. This study highlights negative-pressure wound therapy as the preferred treatment option for complex diabetic foot ulcers, warranting further research into its longterm benefits and cost-effectiveness. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Gu, Haiyun; Zhao, Xiaoqin; Sun, Yi; Ding, Yiyi; Rong, Ouyang] Nantong Univ, Affiliated Hosp, Dept Endocrinol & Metab, Nantong 226001, Peoples R China.
C3 Nantong University
RP Rong, OY (通讯作者)，Nantong Univ, Affiliated Hosp, Dept Endocrinol & Metab, Nantong 226001, Peoples R China.
EM 13962811781@163.com
RI Ding, Yiyi/KEH-1318-2024; zhao, xiaoqing/KWT-6534-2024
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   Wynn M, 2019, J TISSUE VIABILITY, V28, P152, DOI 10.1016/j.jtv.2019.04.001
   Yao M, 2014, INT WOUND J, V11, P483, DOI 10.1111/j.1742-481X.2012.01113.x
   Yazdanpanah L, 2015, WORLD J DIABETES, V6, P37, DOI 10.4239/wjd.v6.i1.37
   Zhang LP, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/8824737
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NR 45
TC 13
Z9 14
U1 9
U2 22
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
EI 1532-7361
J9 SURGERY
JI Surgery
PD APR
PY 2025
VL 180
AR 109098
DI 10.1016/j.surg.2024.109098
EA JAN 2025
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA U6O3D
UT WOS:001412957800001
PM 39793417
DA 2026-07-24
ER
PT J
AU Howell, C
   Simman, R
AF Howell, Caroline
   Simman, Richard
TI Accidental intra-arterial injection of enoxaparin sodium leading to
   abdominal wall expanding subcutaneous hematoma and abdominal wound: case
   report-vascular
SO FRONTIERS IN SURGERY
LA English
DT Article
DE Lovenox; subcutaneous hematoma; anticoagulant; negative pressure wound
   therapy; bleeding; intra-arterial injection
AB Introduction Enoxaparin sodium (Lovenox (R)) is a commonly used anticoagulant medication that is self-administered via subcutaneous injection to prevent the formation of pathologic blood clots. It is used as a bridge to long-term anticoagulation with warfarin in patients at high risk for thromboembolic events. It is generally well-tolerated and has a favorable safety profile. The most common injection site reactions caused by enoxaparin sodium are urticaria, ecchymosis, and skin and fat necrosis.Case Report A 56 year-old female with extensive thromboembolic history was completing an enoxaparin sodium bridge to warfarin when she accidentally self-injected enoxaparin sodium into the left superficial epigastric artery, resulting in the formation of a large expanding hematoma and the development of hemorrhagic shock. Controlling the bleeding required reversal of anticoagulation, transfusion, and coil embolization of the affected arteries. Surgical evacuation of the hematoma was performed, and the resultant wound was managed postoperatively with negative pressure wound therapy (NPWT) for one month. After discontinuation of NPWT, the wound was allowed to heal by secondary intention using dressing changes.Conclusions The findings of this case report suggest that NPWT followed by conventional dressings can be used to close and heal the wound created by surgical hematoma evacuation.
C1 [Howell, Caroline; Simman, Richard] Univ Toledo, Coll Med & Life Sci, Toledo, OH 43614 USA.
   [Simman, Richard] Univ Toledo, Dept Surg, Med Ctr, Div Plast & Reconstruct Surg, Toledo, OH 43614 USA.
   [Simman, Richard] Jobst Vasc Inst, Wound Care Program, ProMed Hlth Network, Toledo, OH 43606 USA.
C3 University System of Ohio; University of Toledo; University System of
   Ohio; University of Toledo
RP Simman, R (通讯作者)，Univ Toledo, Coll Med & Life Sci, Toledo, OH 43614 USA.; Simman, R (通讯作者)，Univ Toledo, Dept Surg, Med Ctr, Div Plast & Reconstruct Surg, Toledo, OH 43614 USA.; Simman, R (通讯作者)，Jobst Vasc Inst, Wound Care Program, ProMed Hlth Network, Toledo, OH 43606 USA.
EM Richard.SimmanMD@ProMedica.org
CR Aldhaeefi M, 2023, PHARMACY-BASEL, V11, DOI 10.3390/pharmacy11010034
   Boer C, 2018, BRIT J ANAESTH, V120, P914, DOI 10.1016/j.bja.2018.01.023
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NR 17
TC 2
Z9 3
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JAN 22
PY 2025
VL 12
AR 1477926
DI 10.3389/fsurg.2025.1477926
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA U6T3H
UT WOS:001413088800001
PM 39911563
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lv, ZM
   Wang, YJ
   Chen, JL
   Zhang, QF
   Zhao, HT
AF Lv, Zhenmu
   Wang, Yujie
   Chen, Jingliang
   Zhang, Qingfu
   Zhao, Haitao
TI Pelnac® artificial dermis assisted by vacuum sealing drainage for
   treatment of severe avulsion injuries of the fingers
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Artificial dermis; Pelnac; Severe avulsion injuries; Functional
   outcomes; Aesthetic outcomes
ID UPPER EXTREMITY; TISSUE DEFECTS
AB PurposeThis study aimed to evaluate the outcomes of Pelnac assisted by vacuum sealing drainage in managing severe avulsion injuries of the fingers.MethodsThis prospective study was conducted from May 2017 to September 2023, involving 12 consecutive patients with severe avulsion injuries of the fingers. Patients underwent single-stage or two-stage procedures employing Pelnac assisted by vacuum sealing drainage (VSD) for the management of severe avulsion injuries of the fingers. Post-operative follow-up was routinely scheduled, and aesthetic and functional outcomes, sensory recovery, complications were recorded.ResultsTwelve patients were included in the analysis, consisting of 9 males and 3 females, with a mean age of 30.6 +/- 11.0 years. All patients presented with severe damage to tendons and deep tissues, as well as varying degrees of bone exposure and injury, with average defect area of 36.9 cm(2) (range, 11 to 180 cm(2)). At the final follow-up (mean, 14 months; range, 12 to 29 months), the average score on the Fingertip Injuries Outcome Score (FIOS) was 14.3 (SD 3.9, range 10 to 22), with 6 patients achieving excellent result, 4 classified as good and 2 as fair. Patients reported an average satisfaction score of 74.0 (SD 11.6; range 51 to 94) regarding the aesthetic appearance. The average score on the Vancouver Scar Scale score was 2.3 (SD 2.1, range 1.0 to 7.4). Ten patients reported normal or near-normal sensation, while 2 patients experienced slight sensory loss. The average score on the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire was 13.2 (SD 8.5, range 0 to 47). No infections or hematomas were reported during hospitalization or after discharge.ConclusionPelnac, assisted by VSD, proved to be an effective approach for managing severe avulsion injuries of the fingers. This approach can be considered as a viable alternative for addressing severe injuries or complex wound conditions.
C1 [Lv, Zhenmu; Zhang, Qingfu] Hebei Med Univ, Hosp 3, Dept Burn & Wound Repair Ctr, 139 Ziqiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
   [Wang, Yujie] Hebei Prov Hosp Tradit Chinese Med, Dept Orthopaed Surg 4, 389 Zhongshan East Rd, Shijiazhuang 050000, Hebei, Peoples R China.
   [Chen, Jingliang] 82nd Grp Army Hosp Peoples Liberat Army, Dept Hand & Foot Surg, 991 Baihua East Rd, Baoding 071000, Hebei, Peoples R China.
   [Zhao, Haitao] Hebei Med Univ, Hosp 3, Dept Foot & Ankle Surg, 139 Ziqiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei University of Chinese Medicine; Hebei
   Medical University
RP Zhao, HT (通讯作者)，Hebei Med Univ, Hosp 3, Dept Foot & Ankle Surg, 139 Ziqiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
EM drzhenmulv@126.com; 378412581@qq.com; 575880829@qq.com;
   16601225@hebmu.edu.cn; drzhaohaitao@126.com
OI Li, Liqiang/0009-0001-5968-4772
FU Hebei Provincial Natural Science Foundation Project
FX We are grateful to J.F. Y.G. L.X. and W.W. of the Department of Burn and
   Wound Repair Center and Y.L. of the Department of Orthopaedic Surgery of
   Hebei Medical University Third Hospital for their kind assistance.
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NR 24
TC 1
Z9 1
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD FEB 4
PY 2025
VL 20
IS 1
AR 136
DI 10.1186/s13018-025-05547-z
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA U8N7H
UT WOS:001414299200005
PM 39905439
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jiang, TT
   Su, YH
   Wu, YK
   Li, C
   Sun, TK
   Li, YH
   Ji, YY
   Wang, ZD
AF Jiang, Tiantian
   Su, Yuanhao
   Wu, Yongke
   Li, Cheng
   Sun, Tingkai
   Li, Yunhao
   Ji, Yuanyuan
   Wang, Zhidong
TI No closure of the linea alba cervicalis reduces complications in
   endoscopic thyroidectomy
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Endoscopic thyroidectomy; Chest-breast; Linea Alba cervicalis;
   Complication; Negative pressure wound therapy (NPWT)
ID PRESSURE WOUND THERAPY; SURGERY; MANAGEMENT; SCARLESS; HEMATOMA; CANCER
AB The benefits of not suturing the linea alba cervicalis and using negative pressure wound therapy after endoscopic thyroidectomy have attracted increasing attention. Therefore, this study aims to determine whether the non-closure of the linea alba cervicalis after endoscopic thyroidectomy can significantly reduce postoperative complications and evaluate the application of NPWT to prevent cavity-related complications. A retrospective analysis was performed. 142 patients were enrolled and divided into two groups, including 71 individuals in the improvement group (no suture of the linea alba cervicalis) and 71 in the conventional group (suture the linea alba cervicalis). Then, the general clinical data and operative indicators were analyzed and compared between the two groups using SPSS 26.0 software. Statistical significance was recognized with P < 0.05. The improvement group showed a lower incidence of neck edema (3/71,4.2% vs. 10/71,14.1%) and a lower score on the Visual Analogue Scale (VAS) 5 days after the operation (3 +/- 1.2 vs. 4 +/- 1.3) between the two groups (P < 0.05), and there is no significant difference in the overall incidence of postoperative complications between the two groups (P>0.05). No closure of the linea alba cervicalis is safe and feasible after endoscopic thyroidectomy via chest-breast approach, with significantly less incidence of neck edema and lower neck discomfort. In addition, NPWT, providing a novel tool to reduce the occurrence of cavity-related complications in current clinical practice, can be used in whether or not to suture the linea alba cervicalis, which is safe and effective.
C1 [Jiang, Tiantian; Su, Yuanhao; Wu, Yongke; Li, Cheng; Sun, Tingkai; Li, Yunhao; Wang, Zhidong] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Gen Surg, Xian 710004, Peoples R China.
   [Ji, Yuanyuan] Xi An Jiao Tong Univ, Affiliated Hosp 2, Precis Med Inst, Sci Res Ctr, Xian 710004, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University
RP Wang, ZD (通讯作者)，Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Gen Surg, Xian 710004, Peoples R China.; Ji, YY (通讯作者)，Xi An Jiao Tong Univ, Affiliated Hosp 2, Precis Med Inst, Sci Res Ctr, Xian 710004, Peoples R China.
EM jiyuanyuan1234@163.com; xawzd@163.com
RI Su, YuanHao/GQA-9051-2022
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NR 47
TC 0
Z9 0
U1 2
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 7
PY 2025
VL 15
IS 1
AR 4577
DI 10.1038/s41598-025-88873-w
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA W1W8M
UT WOS:001416570900009
PM 39920252
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Medina, MM
   Luzarraga, A
   Catalán, S
   Acosta, U
   Hernandez-Fleury, A
   Bebia, V
   Monreal-Clua, S
   Angeles, MA
   Bonaldo, G
   Gil-Moreno, A
   Perez-Benavente, A
   Sanchez-Iglesias, JL
AF Medina, Marta Miguez
   Luzarraga, Ana
   Catalan, Sara
   Acosta, Ursula
   Hernandez-Fleury, Alina
   Bebia, Vicente
   Monreal-Clua, Sonia
   Angeles, Martina Aida
   Bonaldo, Giulio
   Gil-Moreno, Antonio
   Perez-Benavente, Asuncion
   Sanchez-Iglesias, Jose Luis
TI Incisional Hernia in Cytoreductive Surgery for Advanced-Stage Ovarian
   Cancer: A Single-Center Retrospective Study
SO CANCERS
LA English
DT Article
DE ovarian cancer; incisional hernia; small bites technique; ERAS
ID ENHANCED RECOVERY; CHEMOTHERAPY; GUIDELINES; TRIALS
AB Background/Objectives: An incisional hernia (IH) is a frequent postoperative complication after cytoreductive laparotomic surgery for advanced ovarian cancer (AOC). It occurs in 2-22% of patients in the first two years of follow-up, depending on the series. Although different risk factors have been described for various types of malignancies and surgeries, few studies have analyzed the risk factors for hernia development in ovarian cancer (OC). However, none have examined the role of enhanced recovery after surgery (ERAS) programs. Methods: We performed a retrospective study that included patients with AOC and primary or interval debulking surgery through a median laparotomic approach. This study was conducted in Vall d'Hebron Hospital, Barcelona, Spain, between January 2015 and December 2022. Univariate and multivariate regression analyses were conducted. Results: Of the 156 patients included, 30 (19.2%) presented with an IH. The patients with IHs were smokers in a higher proportion to non-smokers (53.9% vs. 16.1%, p = 0.003) and more frequently presented with wound dehiscence (34.4% vs. 15.0%, p = 0.026). Patients in whom negative pressure wound therapy was applied had a hernia less frequently than those who had not had it (12.5% vs. 26.7%, p = 0.043). Similarly, the incidence of hernia decreased when patients went through an ERAS protocol (10.1% vs. 28.8%, p = 0.008). In the multivariate analysis, smoking was the only independent risk factor (RR 10.84, CI 2.76-42.64), and applying an ERAS protocol was seen to be the sole protective factor (RR 0.22, CI 0.08-0.61) against the development of an IH. Conclusions: The implementation of ERAS is highly recommended due to its numerous benefits, most notably the reduction in hernia incidence. Additionally, the preoperative identification of current smokers provides an opportunity for smoking cessation and targeted respiratory prehabilitation, both of which further contribute to IH reduction.
C1 [Medina, Marta Miguez; Luzarraga, Ana; Catalan, Sara; Acosta, Ursula; Hernandez-Fleury, Alina; Bebia, Vicente; Monreal-Clua, Sonia; Angeles, Martina Aida; Bonaldo, Giulio; Gil-Moreno, Antonio; Perez-Benavente, Asuncion; Sanchez-Iglesias, Jose Luis] Hosp Univ Vall dHebron, Dept Gynecol, Gynecol Oncol Unit, Barcelona 08035, Spain.
   [Bebia, Vicente; Angeles, Martina Aida; Gil-Moreno, Antonio; Perez-Benavente, Asuncion] Univ Autonoma Barcelona, Vall dHebron Barcelona Hosp Campus, Gynecol Oncol Div, Barcelona 08035, Spain.
C3 Hospital Universitari Vall d'Hebron; Autonomous University of Barcelona
RP Luzarraga, A (通讯作者)，Hosp Univ Vall dHebron, Dept Gynecol, Gynecol Oncol Unit, Barcelona 08035, Spain.
EM ana.luzarraga@vallhebron.cat
RI ; PEREZ BENAVENTE, ASUNCION/J-8272-2016; Bebia, Vicente/HSD-6708-2023;
   Luzarraga, Ana/JZC-7507-2024; Gil-Moreno, Antonio/C-1122-2016;
   BENAVENTE, ASUNCION/C-5116-2014
OI Míguez Medina, Marta/0000-0001-6401-7192; PEREZ BENAVENTE,
   ASUNCION/0000-0003-1872-9003; Hernandez Fleury,
   Alina/0000-0002-7687-7971; Bebia, Vicente/0000-0001-6434-2112;
   Luzarraga, Ana/0000-0001-6007-0308; Angeles, Martina
   Aida/0000-0003-4401-3084; Gil-Moreno, Antonio/0000-0003-1106-5590; 
CR Bristow RE, 2002, J CLIN ONCOL, V20, P1248, DOI 10.1200/JCO.20.5.1248
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NR 31
TC 0
Z9 1
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD FEB
PY 2025
VL 17
IS 3
AR 418
DI 10.3390/cancers17030418
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA W4N4F
UT WOS:001418360600001
PM 39941787
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ahn, J
   Flaherty, A
AF Ahn, Jiyong
   Flaherty, Alexandra
TI Utility of 3D Wound Assessment in Monitoring Granulation Tissue Velocity
   Following Negative-Pressure Wound Therapy in Diabetic Foot Ulcers
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE amputation; diabetic mellitus; diabetic foot; negative-pressure wound
   therapy; 3D wound assessment
ID AREA
AB Background: Wound healing in diabetic foot ulcers (DFUs) is challenging and often requires extensive debridement and in some cases leads to amputation. Negative-pressure wound therapy (NPWT) can be utilized for DFUs. The optimal time frame for successful NPWT lacks consensus. Advanced wound scanning with a three-dimensional (3D) camera can enhance accuracy of DFU area and volume calculations. This study aimed to investigate the utility of 3D wound assessment in monitoring granulation tissue filling velocity with NPWT in DFUs.Methods: A retrospective case series study was performed for 101 DFUs (Wagner classification 3 or 4 lesions with significant necrotic tissue debridement failing to achieve primary closure, leading to open amputation) undergoing NPWT from September 2018 to June 2019. Demographic data and wound characteristics were recorded. Before application of NPWT, wounds were irrigated after extensive procedures, and digital photographs of the wound were captured using an infrared 3D camera. Wound area and volume were measured weekly from before the application of NPWT to 1 month after. Risk factors associated with wound healing in DFUs were also evaluated.Results: NPWT resulted in significant area improvements for open DFUs. Postoperative 1-week area change velocity was 1.35 cm2/d, peaking at 2 weeks (1.84 cm2/d). Volume also showed significant improvement over time (P = .001), with a 1-week peak velocity of 1.20 cm3/d. All peak area and volume changes occurred within 2 weeks after NPWT application. Compared to the midfoot and hindfoot, the forefoot exhibited a lower velocity of volume (P = .001).Conclusion: 3D wound assessment for the velocity of granulation tissue filled in an open DFU after NPWT can be useful for monitoring healing progression. Most wound healing following NPWT in DFUs was completed within the first 2 weeks.
C1 [Ahn, Jiyong] Bumin Hosp Seoul, Dept Orthopaed Surg, 389 Gonghang Daero, Seoul 07590, South Korea.
   [Ahn, Jiyong; Flaherty, Alexandra] Harvard Med Sch, Massachusetts Gen Hosp MGH, Dept Orthopaed Surg, Foot & Ankle Res & Innovat Lab FARIL, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School
RP Ahn, J (通讯作者)，Bumin Hosp Seoul, Dept Orthopaed Surg, 389 Gonghang Daero, Seoul 07590, South Korea.
EM ilmon@hanmail.net
RI Ahn, Ji-Yong/KDN-0493-2024
OI Ahn, Ji-Yong/0000-0003-0309-2193
FU Department of Orthopaedic Surgery funded by Catholic University of Korea
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by a grant of the Department of Orthopaedic Surgery funded
   by Catholic University of Korea made in the program year of 2018.
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NR 25
TC 0
Z9 0
U1 4
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD MAR
PY 2025
VL 46
IS 3
BP 287
EP 294
DI 10.1177/10711007251314805
EA FEB 2025
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 0AM5C
UT WOS:001420820200001
PM 39950603
DA 2026-07-24
ER
PT J
AU Kabakuli, AN
   Budema, PM
   Toha, GK
   Tawimbi, HW
   Musilimu, CS
   Docquier, PL
AF Kabakuli, A. Namugusha
   Budema, P. munguakonkwa
   Toha, G. kuyigwa
   Tawimbi, H. wilonja
   Musilimu, C. sudi
   Docquier, Pl
TI Low-cost negative pressure wound therapy for gunshot traumatism in
   developing countries
SO ACTA ORTHOPAEDICA BELGICA
LA English
DT Article
DE Gunshot wound; vacuum assisted closure; VAC therapy..
ID VACUUM-ASSISTED CLOSURE
AB Wounds from gunshots and other explosive devices are a source of loss of substances directly or secondary to a wellconducted debridement. In addition, these types of wounds are by definition contaminated. The major challenge in this context for any surgeon remains coverage. The use of flap-type plastic surgery is one of the options if feasible. Another option is the use of vacuum dressing. VAC therapy gives better results than sugar and honey. In a humid environment, it ensures the drainage of exudates. It causes an increase in local blood flow by stimulating neoangiogenesis, it stimulates cell proliferation and also the granulation tissue. It leads to a decrease in bacterial colonization and tissue oedema. Four observations are presented to illustrate the feasibility of this treatment in developing country and to show its beneficial effects.
C1 [Kabakuli, A. Namugusha; Budema, P. munguakonkwa; Toha, G. kuyigwa; Tawimbi, H. wilonja; Musilimu, C. sudi] Univ Catholique Bukavu, Fac med, Bukavu, DEM REP CONGO.
   [Kabakuli, A. Namugusha] Hop Prov Gen Reference Bukavu, Bukavu, DEM REP CONGO.
   [Kabakuli, A. Namugusha; Docquier, Pl] Clin Univ St Luc, Serv orthoped & traumatol appareil locomoteur, Ave Hippocrate 10, B-1200 Brussels, Belgium.
   [Docquier, Pl] Catholic Univ Louvain, Inst Rech Expt & Clin, Neuro Musculo Skeletal Lab NMSK, Sect Sci Sante, Brussels, Belgium.
C3 Catholic University of Bukavu; Universite Catholique Louvain; Cliniques
   Universitaires Saint-Luc; Universite Catholique Louvain
RP Docquier, PL (通讯作者)，Clin Univ St Luc, Serv orthoped & traumatol appareil locomoteur, Ave Hippocrate 10, B-1200 Brussels, Belgium.
EM Pierre-Louis.Docquier@uclouvain.be
CR Andrabi Syed Imran Hussain, 2007, J Ayub Med Coll Abbottabad, V19, P89
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NR 29
TC 0
Z9 0
U1 0
U2 0
PU ACTA MEDICA BELGICA
PI BRUSSELS
PA AVENUE WINSTON CHURCHILL, WINSTON CHURCHILL-LAAN, 11 BOX 30, B-1180
   BRUSSELS, BELGIUM
SN 0001-6462
J9 ACTA ORTHOP BELG
JI Acta Orthop. Belg.
PD SEP
PY 2024
VL 90
IS 3
BP 449
EP 453
DI 10.52628/90.3.11266
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA W8N2D
UT WOS:001421064000011
PM 39851017
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Ranjan, P
   Rishika
   Mondal, S
AF Ranjan, Piyush
   Rishika, Saptarshi
   Mondal, Saptarshi
TI Randomized Clinical Trial of Vacuum-Assisted Closure Versus Conventional
   Dressings in Patients with Diabetic Foot Ulcers
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Diabetic ulcer; Vacuum dressing; Normal saline dressing; Lower limb
ID WOUND CONTROL
AB The objective of this study was to evaluate the comparative efficacy of vacuum-assisted closure (VAC) and conventional dressing methods in the management of diabetic foot ulcers. The assessment focused on specific parameters, including the rate of granulation tissue formation, the bacterial clearance upon completion of therapy, and the duration required for wound healing. This randomized comparative study was conducted in the Department of General Surgery, Indira Gandhi Institute of Medical Sciences, Patna, from January 2021 to December 2022. Fifty patients with lower limb diabetic ulcers were included and randomized into two groups: conventional dressing (n = 31) and vacuum-assisted closure (VAC) dressing (n = 19). Patient outcomes after dressing were compared. Statistical analysis was performed using SPSS software, and a p value < 0.05 was considered statistically significant. Compared to conventional dressing, the vacuum-assisted closure (VAC) dressing group had comparable age, gender, and associated comorbidities (p value > 0.05). The VAC group exhibited a shorter, albeit comparable, duration for granulation tissue to appear (6.94 +/- 2.61 vs. 9.03 +/- 2.30, p value 0.29), a significantly shorter duration for wound culture to become negative (11.36 +/- 4.47 vs. 14.83 +/- 3.89, p value 0.037), and a significantly reduced duration for wound healing (36.84 +/- 9.34 vs. 43.16 +/- 9.22, p value 0.033). The present randomized study comparing vacuum-assisted closure (VAC) dressing with conventional dressing for diabetic foot ulcers, after controlling for several factors affecting wound healing in diabetes, demonstrated results favoring VAC.
C1 [Ranjan, Piyush; Mondal, Saptarshi] IGIMS, Dept Gen Surg, Patna, Bihar, India.
RP Ranjan, P (通讯作者)，IGIMS, Dept Gen Surg, Patna, Bihar, India.
EM golu1piyush@gmail.com
OI Ranjan, Piyush/0009-0007-8953-9836
CR Atef Bayoumi AASAM, 2018, The Egyptian Journal of Hospital Medicine, V72, P4054, DOI [10.21608/ejhm.2018.9115, 10.21608/ejhm.2018.9115, DOI 10.21608/EJHM.2018.9115]
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NR 17
TC 2
Z9 2
U1 2
U2 2
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD AUG
PY 2025
VL 87
IS 4
BP 724
EP 728
DI 10.1007/s12262-025-04301-3
EA FEB 2025
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6CF8U
UT WOS:001421481200001
DA 2026-07-24
ER
PT J
AU Hu, SQ
   Xiao, J
   Nie, X
   Wang, C
AF Hu, Sunqiang
   Xiao, Jin
   Nie, Xin
   Wang, Chi
TI Vacuum sealing drainage combined with continuous irrigation for the
   treatment of oral and maxillofacial abscesses-a retrospective study
SO BMC ORAL HEALTH
LA English
DT Article
DE Oral and maxillofacial abscess; Vacuum sealing drainage; Treatment
ID PRESSURE WOUND THERAPY; ASSISTED CLOSURE; NEGATIVE-PRESSURE; MANAGEMENT;
   COMBINATION; INFECTIONS; APPEARANCE; IMPACT; COST; LIFE
AB Objective The conventional treatment for oral and maxillofacial abscesses involves incision and drainage. However, postoperative dressing changes often cause pain and other discomfort to patients. Therefore, we explored the use of vacuum sealing drainage (VSD) technology for treating oral and maxillofacial abscesses. In this retrospective study, we evaluated the efficacy and value of VSD combined with continuous irrigation using physiological saline to treat oral and maxillofacial abscesses. Materials and methods Data from 115 patients with oral and maxillofacial abscesses were collected. Patients were divided into two groups based on the treatment strategy: 68 received traditional treatment (Group 1) and 47 were treated with the VSD device (Group 2). The treatment period, incision length and numerical rating scale (NRS) score were compared between the two groups. Postoperative complications were also recorded. Results All patients were successfully treated and discharged. Group 2 had a longer treatment duration (10.00 +/- 5.87 days) than Group 1 (8.07 +/- 3.47 days; p < 0.05) but demonstrated shorter incision lengths (3.04 +/- 0.31 cm vs. 3.57 +/- 0.44 cm; p < 0.01) and lower NRS scores on postoperative day 1 (1.83 +/- 0.70 vs. 2.96 +/- 0.83; p < 0.01). Complications included two allergic reactions to adhesive material in Group 2 and higher reoperation rates (Group 2: 4 cases; Group 1: 1 case). Conclusion VSD treatment for localized oral and maxillofacial abscesses is comfortable for patients and can reduce the length of surgical incisions. However, the therapeutic effect for maxillofacial multispace infection is still controversial.
C1 [Hu, Sunqiang; Xiao, Jin; Nie, Xin; Wang, Chi] Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, 373 West Coll Rd, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Wenzhou Medical University
RP Wang, C (通讯作者)，Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, 373 West Coll Rd, Wenzhou 325000, Zhejiang, Peoples R China.
EM wangchdoctor@wmu.edu.cn
RI Nie, Xilin/KHE-3293-2024
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NR 39
TC 2
Z9 4
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6831
J9 BMC ORAL HEALTH
JI BMC Oral Health
PD FEB 18
PY 2025
VL 25
IS 1
AR 257
DI 10.1186/s12903-025-05634-x
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA X4Q3Q
UT WOS:001425210700009
PM 39966789
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lee, SYC
   Bayan, L
   Sato, A
   Vankayalapati, DK
   Antoniou, V
   Shami, MZ
   Sulaiman, HO
   Yap, N
   Nakanishi, H
   Than, CA
   Wong, KY
AF Lee, Sum-Yu Christina
   Bayan, Laith
   Sato, Alma
   Vankayalapati, Dilip K.
   Antoniou, Valeria
   Shami, M. Zaid
   Sulaiman, Hafsa Omer
   Yap, Nathanael
   Nakanishi, Hayato
   Than, Christian A.
   Wong, Kai Yuen
TI Benefits of negative pressure wound therapy in skin grafts: A systematic
   review and meta-analysis of randomised controlled trials
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Negative pressure wound therapy; NPWT; VAC; Wound dressings; Skin
   grafts; Graft take
ID VACUUM-ASSISTED CLOSURE; CONVENTIONAL THERAPY; COST; INSTILLATION;
   INTEGRATION; DRESSINGS; DRAINAGE; NPWT; FOOT; NECK
AB Background: Negative pressure wound therapy (NPWT) is a widely used adjunct for wound healing and an alternative to conventional dressings for skin grafts. This meta-analysis aimed to quantify the effectiveness of NPWT versus conventional dressings in this population through randomised control trials (RCTs). Methods: A literature search in several databases was conducted from inception to October 2023. Eligible studies were RCTs reporting the efficacy and post-operative outcomes of NPWT and non-NPWT (control) in patients >= 18 years with skin grafts. Pooled proportions were analysed using a random-effects model. This review was registered prospectively with PROSPERO (CRD42023471105). Results: Overall, 16 RCTs met the criteria for inclusion in the meta-analysis. This included 411 patients and 401 controls. Compared to conventional dressings, NPWT demonstrated 8.3% higher overall graft take (95% CI: 2.97, 13.63, I2 = 85%), 10.0% higher graft take at -80 mmHg (95% CI: 5.69, 14.34, I2 = 0%), higher graft success rates (OR = 1.86, 95% CI: 1.05, 3.30, I2 = 0%), lower graft loss rates (OR = 0.44, 95% CI: 0.23, 0.85, I2 = 0%), lower complication rates (OR = 0.36, 95% CI: 0.13, 0.99, I2 = 76%) and lower reoperation rates (OR = 0.31, 95% CI: 0.13, 0.72, I2 = 0%). Conclusion: NPWT is a safe and effective approach for dressing skin grafts in adult patients compared to conventional wound dressings. NPWT improved graft take and graft success while reducing graft failure, reoperations and overall complications. (c) 2025 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Lee, Sum-Yu Christina; Bayan, Laith; Sato, Alma; Antoniou, Valeria; Yap, Nathanael; Than, Christian A.] Univ Nicosia, Med Sch, Dept Basic & Clin Sci, CY-2408 Nicosia, Cyprus.
   [Vankayalapati, Dilip K.] Oxford Thames Valley Fdn Sch, Buckinghamshire NHS Trust, Oxford, England.
   [Shami, M. Zaid] HCA Florida Aventura Hosp & Med Ctr, Aventura, FL USA.
   [Sulaiman, Hafsa Omer] Cleveland Clin Fdn, Digest Dis & Surg Inst, Cleveland, OH USA.
   [Yap, Nathanael; Than, Christian A.] St Georges Univ London, London SW17 0RE, England.
   [Nakanishi, Hayato; Than, Christian A.] Mayo Clin, Dept Surg, Rochester, MN USA.
   [Than, Christian A.] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
   [Wong, Kai Yuen] Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England.
C3 University of Nicosia; Cleveland Clinic Foundation; City St Georges,
   University of London; Mayo Clinic; University of Queensland; University
   of Cambridge
RP Lee, SYC (通讯作者)，Univ Nicosia, UNIC Med Sch, Block A,93 Agiou Nikolaou St, CY-2408 Nicosia, Cyprus.
EM lee.sum@live.unic.ac.cy
OI Lee, Sum-Yu Christina/0000-0001-7584-1662; Wong, Kai
   Yuen/0000-0002-6060-1487; Vankayalapati, Dilip
   Kumar/0000-0002-1531-7401; Than, Christian/0000-0002-4193-9925;
   Antoniou, Valeria/0009-0001-6086-6151; Sato, Alma/0009-0006-5904-9927;
   Shami, M Zaid/0009-0002-9161-056X
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NR 62
TC 7
Z9 9
U1 2
U2 5
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAR
PY 2025
VL 102
BP 204
EP 217
DI 10.1016/j.bjps.2025.01.036
EA JAN 2025
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA X6K5O
UT WOS:001426414800001
PM 39932531
DA 2026-07-24
ER
PT J
AU Lonneman, MK
   Pumiglia, L
   Zhang, B
   Edinger, AA
   Dejong, J
   Akinmoladun, OO
   Van Eaton, JC
   Kelly, A
   Dolezal, K
   Enzerink, A
   Glaser, JJ
   Bingham, JR
   Oliver, J
AF Lonneman, M. K.
   Pumiglia, L.
   Zhang, B.
   Edinger, A. A.
   Dejong, J.
   Akinmoladun, O. O.
   Van Eaton, J. C.
   Kelly, A.
   Dolezal, K.
   Enzerink, A.
   Glaser, J. J.
   Bingham, J. R.
   Oliver, J.
TI "Sucking the trouble" out of troubleshooting wound vacs: Video based
   curriculum development and implementation in a live tissue model
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID AEROMEDICAL EVACUATION; THERAPY; EDUCATION
AB We hypothesized that non-surgeon, Negative Pressure Wound Therapy (NPWT) na & iuml;ve participants would better identify device functions and troubleshoot failures after being exposed to a video curriculum (VC) compared to similar participants exposed to clinical practice guidelines (CPGs). VC and critical action step development was followed by randomization of 115 non-surgical, NPWT na & iuml;ve participants into either the CPG or VC study groups. Participants individually identified components of the NPWT system and then worked as a team to troubleshoot three scenarios on an in vivo porcine model. VC participants better identified all NPWT components and functions (p < 0.001), demonstrated correct cannister attachment (p < 0.001) and performed a seal check (p < 0.001). VC teams performed more critical action steps in the leak (p = 0.011) and obstruction (p = 0.001) scenarios. In post-event surveys, participants were more likely to find the VC easy to use and informative and were likely to recommend the videos to a colleague (p = 0.008, p = 0.019, p = 0.02). VC participants demonstrated improved competency in individual NPWT component identification and team-based troubleshooting of NPWT failures. This VC represents an effective alternative to existing CPGs.
C1 [Lonneman, M. K.; Pumiglia, L.; Zhang, B.; Edinger, A. A.; Dejong, J.; Akinmoladun, O. O.; Van Eaton, J. C.; Kelly, A.; Dolezal, K.; Enzerink, A.; Glaser, J. J.; Bingham, J. R.; Oliver, J.] Madigan Army Med Ctr, 9040A Jackson Ave, Joint Base Lewis Mcchord, WA 98431 USA.
C3 Madigan Army Medical Center
RP Lonneman, MK (通讯作者)，Madigan Army Med Ctr, 9040A Jackson Ave, Joint Base Lewis Mcchord, WA 98431 USA.
EM mklonneman@gmail.com
RI ; Bingham, Jason/N-6822-2019; Glaser, Jacob/PKG-6438-2026
OI Zhang, Bobby/0009-0001-7771-1981; 
FU The 59th Medical Wing
FX This work was supported by the 59th Medical Wing with administrative
   support provided by the Geneva Foundation.
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NR 23
TC 0
Z9 0
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2025
VL 243
AR 116244
DI 10.1016/j.amjsurg.2025.116244
EA FEB 2025
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA Y0A4O
UT WOS:001428860900001
PM 39956036
DA 2026-07-24
ER
PT J
AU Wardell, C
   Whitworth, S
   Wolfe, J
AF Wardell, Cooper
   Whitworth, Steven
   Wolfe, Jennifer
TI Buttock Necrosis Following Uterine Artery Embolization: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE fibroid; leiomyoma; necrosis; negative pressure wound therapy; uterine
   artery embolization
AB Background. Uterine artery embolization (UAE) is an increasingly common procedure for the management of uterine leiomyoma (fibroid). Up to 70% of White women and more than 80% of women of African ancestry will develop benign fibroid tumors of the uterus, many of whom will have symptoms including increased menstrual bleeding, urinary symptoms, pain, and infertility. When medical management does not adequately treat symptoms, UAE is a minimally invasive surgical treatment option. Nontarget embolization is a rare complication of this procedure and can result in soft tissue necrosis. Few case reports describe this phenomenon. Case Report. A 46-year-old female presented to the wound clinic 5 months after UAE. Following this procedure, the patient developed burning pain in the thigh and buttock. After 5 weeks, a small eschar formed over the right buttock, which progressed to a large necrotic ulceration. The patient was treated successfully, with wound closure by secondary intention occurring 24 weeks after initial presentation. Treatment included sharp debridement, advanced dressings, oral antibiotics (for infection), and negative pressure wound therapy. Conclusion. This case adds to the body of literature describing a full-thickness wound forming due to nontarget embolization. The patient was treated successfully in clinic without the need for further surgery or inpatient treatment.
C1 [Wardell, Cooper; Whitworth, Steven; Wolfe, Jennifer] Piedmont Rockdale Hosp, Wound Care & Hyperbar Ctr, Conyers, GA USA.
RP Wardell, C (通讯作者)，Piedmont Rockdale Hosp, Wound Care, 1412 Milstead Ave, Conyers, GA 30012 USA.
EM cooper.wardell@gmail.com
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2025
VL 37
IS 1
BP 1
EP 4
DI 10.25270/wnds/24025
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA Y0M4E
UT WOS:001429174500001
PM 39982382
DA 2026-07-24
ER
PT J
AU Zhu, YP
   Zhang, XZ
   Zhang, YF
   Zhong, XJ
   Lu, XY
   Zhai, YR
AF Zhu, Yaping
   Zhang, Xiuzhen
   Zhang, Yufan
   Zhong, Xiaojuan
   Lu, Xiangyue
   Zhai, Yanrong
TI Nonsurgical Management of Pressure Injury With a New Silicone Rubber
   Negative Pressure Wound Therapy With Instillation Device: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; silicone rubber; anti-blocking negative
   pressure drainage tube with instillation; catheter obstruction; negative
   pressure wound therapy; pressure injury; silicone rubber
ID DWELL TIME; HOLES
AB Background. Surgical debridement and flap-based reconstruction are essential procedures for managing stage 3 and 4 pressure injuries (PIs). However, the recurrence of PIs after flap reconstruction is high; moreover, many patients cannot tolerate surgical management. Case Report. An 81-year-old male presented with 3 stage 4 PIs (1 each on the sacral region and heels) that were successfully treated without surgical management. The patient was bedridden with progressive dementia, pneumonia, and malnutrition. He could not tolerate thorough debridement. A new silicone rubber negative pressure drainage tube with instillation device was applied to the wounds on the right heel, left heel, and sacral region for 20, 25, and 80 days, respectively, until the wounds were filled with healthy granulation tissue. This device comprises a principal, a connector, an instillation, and a negative pressure drainage tube. The principal part of the device is made of medical-grade silicone rubber shaped into a columnar structure; there is also an instillation channel in the center of the principal tube, forming an instillation loop and ensuring the whole wound is thoroughly instilled. The wounds treated in this case healed without thorough debridement or flap-based reconstruction and had not recurred as of 1-year follow-up. Conclusion. Wound healing was achieved without thorough debridement or flap reconstruction, using a new silicone rubber anti-blocking negative pressure wound therapy with instillation device that was able to remove thick exudate and slough.
C1 [Zhu, Yaping; Zhang, Xiuzhen; Zhang, Yufan; Zhong, Xiaojuan; Lu, Xiangyue; Zhai, Yanrong] Suzhou Wuzhong Peoples Hosp, Dept Gastroenterol, Soochow North Rd 61, Suzhou 215128, Jiangsu, Peoples R China.
RP Zhai, YR (通讯作者)，Suzhou Wuzhong Peoples Hosp, Dept Gastroenterol, Soochow North Rd 61, Suzhou 215128, Jiangsu, Peoples R China.
EM zhaiyanrong1885@126.com
FU Science and Technology Innovation Plan of Suzhou [SKY2022033]
FX This work was supported by Science and Technology Innovation Plan of
   Suzhou (SKY2022033) . The authors disclose no other conflicts of
   interest.
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   Sahin E, J
   Scarpa C, 2024, WOUNDS, V36, P67, DOI 10.25270/wnds/23081
   Shi JY, 2023, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011334.pub3
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NR 18
TC 0
Z9 0
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2025
VL 37
IS 1
BP 8
EP 12
DI 10.25270/wnds/24080
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA Y0M4E
UT WOS:001429174500003
PM 39982384
DA 2026-07-24
ER
PT J
AU Wang, Q
   Yang, XL
   Wei, ZY
   Lin, TL
   Wang, LF
AF Wang, Qian
   Yang, Xiaolan
   Wei, Zhiyi
   Lin, Tianlai
   Wang, Longfeng
TI The Effect of NPWT on Odontogenic Cervical Necrotizing Fasciitis
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Cervical Necrotizing fasciitis (CNF); negative pressure wound therapy
   (NPWT); odontogenic infection
AB Objective: To investigate the clinical efficacy of negative pressure wound therapy (NPWT) in the treatment of odontogenic cervical Necrotizing fasciitis (CNF). Methods: Sixteen cases of odontogenic cervical necrotizing fasciitis were randomly divided into observation group and control group after routine debridement and disinfection. The patients in the control group were treated with drainage tube and regular dressing changes, while those in the observation group were treated with NPWT. The therapeutic effects of the 2 groups were compared. Results: The frequency of operation, treatment length, and cost of treatment in the observation group were significantly less than those in the control group (P<0.05). During the treatment, the VAS (visual analog scale of pain) in the observation group was significantly lower than that in the control group (P<0.05). The levels of WBC, CRP, PCT, IL-6, and TNF-alpha in the observation group were lower than those in the control group (P<0.05). The levels of Il-10 and VEGF in the observation group were higher than those in the control group (P<0.05), the difference was statistically significant. Conclusions: The condition of odontogenic cervical necrotizing fasciitis progresses rapidly. Compared with conventional drainage and dressing change, NPWT can control infection in a short time, reduce operation frequency and treatment cost, and promote wound healing, shorten the treatment time, ease the pain of patients, improve the quality of life. The therapeutic scheme is safe, effective, and suitable for clinical application.
C1 [Wang, Qian; Wang, Longfeng] Quanzhou First Hosp, Quanzhou Med Coll, Quanzhou, Fujian, Peoples R China.
   [Yang, Xiaolan; Wei, Zhiyi] Quanzhou First Hosp, Dept Burn Intens Care Unit, 250 Dongjie Rd, Quanzhou 362000, Fujian, Peoples R China.
   [Lin, Tianlai] Quanzhou First Hosp, Dept Intens Care Unit, Quanzhou, Fujian, Peoples R China.
RP Wei, ZY (通讯作者)，Quanzhou First Hosp, Dept Burn Intens Care Unit, 250 Dongjie Rd, Quanzhou 362000, Fujian, Peoples R China.
EM 236015379@qq.com; 278897140@qq.com; wwdoctor520@sina.com;
   LTL688@163.com; 731185317@qq.com
FU Quanzhou City Science and Technology Program [2022NS0073]
FX Supported by Quanzhou City Science and Technology Program (2022NS0073).
CR Amponsah EK, 2021, J CRANIOFAC SURG, V32, pE547, DOI 10.1097/SCS.0000000000007528
   Malm IA, 2022, J CLIN MED, V11, DOI 10.3390/jcm11051182
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NR 17
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD MAR-APR
PY 2025
VL 36
IS 2
BP e227
EP e231
DI 10.1097/SCS.0000000000010564
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA Y2I2W
UT WOS:001430420800009
PM 39283081
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Huang, YX
   Yu, ZY
   Xu, MR
   Zhao, XT
   Tang, YZ
   Luo, L
   Deng, DT
   Chen, MW
AF Huang, Yixuan
   Yu, Zhenyi
   Xu, Murong
   Zhao, Xiaotong
   Tang, Yizhong
   Luo, Li
   Deng, Datong
   Chen, Mingwei
TI Negative pressure wound therapy promotes wound healing by
   down-regulating miR-155 expression in granulation tissue of diabetic
   foot ulcers
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Diabetic foot ulcer (DFU); Negative pressure wound therapy (NPWT);
   Normal human dermal fibroblasts (NHDFs); MicroRNA; miR-155
AB Our study aims to investigate the effect of negative pressure wound therapy (NPWT) on microRNA-155 (miR-155) in the granulation tissue of patients suffering from diabetic foot ulcers (DFUs) and its correlation with wound healing. A total of sixty patients diagnosed with DFUs were randomly assigned to either the NPWT group (n = 40) or the Non-NPWT group (n = 20) in a 2:1 ratio. After debridement, the NPWT group received NPWT treatment for one week, while the Non-NPWT group underwent routine dressing therapy. The expression of miR-155 in DFU granulation tissues was evaluated by qRT-PCR before and after treatment for one week. Following termination, wound healing rates were assessed in the NPWT group, and the correlation between variations in miR-155 expression (Delta miR-155) and wound healing was analyzed pre and post NPWT treatment. In vitro experiments were conducted to investigate the effects of negative pressure on variations of miR-155 expression, as well as proliferation, migration, and apoptosis in normal human dermal fibroblasts (NHDFs). The NPWT group showed a decrease in miR-155 expression in wound granulation tissue compared with pre-treatment [4.12 (1.22, 14.85) vs. 6.83 (2.15, 15.72), P < 0.05]. Conversely, there was no statistically significant difference in miR-155 expression in wound granulation tissue between pre-treatment and post-treatment in the Non-NPWT group (P > 0.05). However, analysis revealed a positive correlation between Delta miR-155 and wound healing rate after 4 weeks in the NPWT group (chi 2 = 4.829, P = 0.028). The in vitro experiments showed a significant decrease in miR-155 expression in NHDFs under negative pressure measured at -125 mmHg (P < 0.05). This reduction in miR-155 expression, in turn, enhanced the proliferation and migration ability while decreasing the apoptosis rate of NHDFs by targeting the upregulation of fibroblast growth factor 7 (FGF7) gene expression (P < 0.05). It is concluded that NPWT promotes DFU healing by reducing the expression of miR-155 in granulation tissue and the efficacy of NPWT correlated with altered miR-155 expression in wound tissue.
C1 [Huang, Yixuan; Yu, Zhenyi; Xu, Murong; Zhao, Xiaotong; Luo, Li; Deng, Datong; Chen, Mingwei] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
   [Tang, Yizhong] Anhui Med Univ, Affiliated Hosp 1, Dept Burn, Hefei 230032, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Chen, MW (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
EM chmw1@163.com
FU Natural Science Foundation of Anhui Province in China; Department of
   Endocrinology in the First Affiliated Hospital of Anhui Medical
   University
FX We are grateful to the all patients for participating in the study. We
   thank the participants of this study including the doctors, nurses, and
   researchers from the Department of Endocrinology in the First Affiliated
   Hospital of Anhui Medical University.
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NR 29
TC 8
Z9 9
U1 2
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 25
PY 2025
VL 15
IS 1
AR 6733
DI 10.1038/s41598-025-90643-7
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Y5S0C
UT WOS:001432705000045
PM 40000694
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Frieders-Justin, V
   Eckmann, C
   Glaser, B
AF Frieders-Justin, Viktor
   Eckmann, Christian
   Glaser, Benjamin
TI Appropriate surgical management in skin and soft tissue infections
SO CURRENT OPINION IN INFECTIOUS DISEASES
LA English
DT Review
DE negative pressure wound therapy; necrotizing soft tissue infections;
   surgical management of skin and soft tissue infections
ID RESISTANT STAPHYLOCOCCUS-AUREUS; PLACEBO-CONTROLLED TRIAL; RISK;
   ANTIBIOTICS; DEBRIDEMENT; DIAGNOSIS; ABSCESSES; GUIDANCE; ADULTS
AB Purpose of reviewTo present standards and recent technical innovations in the surgical management of skin and soft tissue infections (SSTI).Recent findingsSSTI are a frequent cause of presentation in the acute care setting. They can range from simple and uncomplicated to severe and necrotizing infections. Surgical management plays an important role in the treatment of uncomplicated SSTI. Recent evidence indicates that a subgroup of patients (e.g. immunocompromised patients) profits from a postoperative course of antibiotic treatment of 5-7 days. In diabetic foot infections (DFI), repeated debridement to remove necrotic tissue and control infection can prevent minor and major amputation. In necrotizing soft tissue infections (NSTI), early and aggressive surgical debridement is paramount. Recent advancements have explored skin-sparing techniques in selective cases.SummaryThe management of SSTIs requires a combination of surgical and antimicrobial strategies tailored to the type and severity of the infection. Further clinical research is necessary in order to define more accurately those collectives in severe SSTI who profit from a less aggressive surgical approach.
C1 [Frieders-Justin, Viktor] Med Univ Graz, Sect Surg Res, Graz, Austria.
   [Frieders-Justin, Viktor; Glaser, Benjamin] Klin Donaustadt, Vienna Healthcare Grp, Dept Surg, Vienna, Austria.
   [Eckmann, Christian] Acad Hosp Goettingen Univ, Dept Gen Visceral & Thorac Surg, Klinikum Hanoversch Muenden, Vogelsang 10, D-34346 Hanoversch Muenden, Germany.
C3 Medical University of Graz
RP Eckmann, C (通讯作者)，Acad Hosp Goettingen Univ, Dept Gen Visceral & Thorac Surg, Klinikum Hanoversch Muenden, Vogelsang 10, D-34346 Hanoversch Muenden, Germany.
EM chr.eckmann@gmx.de
RI Glaser, Benjamin/F-8411-2017
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NR 54
TC 4
Z9 6
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7375
EI 1473-6527
J9 CURR OPIN INFECT DIS
JI Curr. Opin. Infect. Dis.
PD APR
PY 2025
VL 38
IS 2
BP 136
EP 142
DI 10.1097/QCO.0000000000001088
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA Y8S8V
UT WOS:001434759500016
PM 39786981
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Huang, RZ
   Cai, YT
   Zheng, TQ
   Lin, Q
AF Huang, Ruize
   Cai, Yangting
   Zheng, Tingqu
   Lin, Qiang
TI A case report on the successful treatment of a specific type of open
   ankle fracture-dislocation called logsplitter injury
SO SCIENCE PROGRESS
LA English
DT Article
DE Logsplitter injury; open fracture reduction; bone cements; negative
   pressure wound therapy; case report
ID OUTCOMES
AB This case report presents the successful management of a rare and complex open ankle fracture-dislocation known as a 'Logsplitter Injury', resulting from a high-energy traumatic event. The patient, a Chinese male in his early 20 s, sustained a severe left lower limb injury in a traffic accident. Initial clinical assessments revealed significant swelling, pain and an open fracture with extensive soft tissue damage. The patient underwent an emergency surgical intervention, involving meticulous wound debridement, internal fixation and reconstruction of the lower tibiofibular union, was performed. The use of vancomycin-loaded polymethylmethacrylate bone cement and negative pressure wound therapy contributed to the favourable outcome. Post-operative care encompassed comprehensive analgesia and infection prevention measures, resulting in substantial ankle function recovery. Follow-up assessments revealed healed fractures and excellent joint alignment, with the patient attaining an AOFAS score of 85, indicative of good functional recovery. This case underscores the effectiveness of individualised treatment plans and multidisciplinary teamwork in managing such challenging injuries, offering valuable clinical insights and highlighting the potential for successful outcomes with timely and precise surgical interventions.
C1 [Huang, Ruize; Cai, Yangting] Guangzhou Univ Tradit Chinese Med, Guangzhou, Peoples R China.
   [Cai, Yangting; Lin, Qiang] Guangdong Pharmaceut Univ, Affiliated Hosp 1, Dept Orthoped, Guangzhou, Peoples R China.
   [Zheng, Tingqu] Shenzhen Pingle Orthoped Hosp, Dept Orthoped, Shenzhen, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangdong Pharmaceutical
   University
RP Lin, Q (通讯作者)，Guangdong Pharmaceut Univ, Affiliated Hosp 1, Dept Orthoped, Guangzhou, Peoples R China.
EM 20211120785@stu.gzucm.edu.cn
OI HUANG, Rui-Ze/0000-0001-5476-0919; Cai, Yang-Ting/0000-0003-3549-7793
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NR 15
TC 1
Z9 1
U1 1
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0036-8504
EI 2047-7163
J9 SCI PROGRESS-UK
JI Sci. Prog.
PD JAN
PY 2025
VL 108
IS 1
AR 00368504251324345
DI 10.1177/00368504251324345
PG 12
WC Education, Scientific Disciplines; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Education & Educational Research; Science & Technology - Other Topics
GA Z1Z7J
UT WOS:001436979800001
PM 40033522
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mucha, AW
   Strandby, RB
   Nerup, NA
   Achiam, MP
AF Mucha, Andreas Weise
   Strandby, Rune Broni
   Nerup, Nikolaj Albeck
   Achiam, Michael Patrick
TI Treatment of intrathoracic anastomotic leakage following esophagectomy
   for gastroesophageal cancer: a systematic review
SO DISEASES OF THE ESOPHAGUS
LA English
DT Article
DE anastomotic leak; drainage; esophagectomy; gastrointestinal endoscopy;
   stent; systematic review
ID VACUUM-ASSISTED CLOSURE; TUBE DRAINAGE; METAL STENTS; MANAGEMENT;
   RESECTION; COMPLICATIONS; PREDICTORS; PLACEMENT; THERAPY
AB Anastomotic leakage (AL) is a significant complication following esophagectomy. AL affects 8%-17% of patients and is associated with increased morbidity, mortality, and hospital stay. To this date, no consensus exists on the most optimal treatment. This systematic review aimed to determine the most effective treatment approach. A systematic search of Medline, Web of Science, Cochrane, Scopus, and Embase databases was conducted. Only studies reporting on the treatment of intrathoracic anastomotic leakage after esophagectomy with gastric conduit reconstruction for cancer were included. Studies investigating other esophageal disorders or failing to report the location of the anastomosis were excluded. The methodological quality and risk of bias were assessed using the Newcastle-Ottawa Scale for cohort studies. Out of 12,966 identified studies, 38 were included for analysis after removing duplicates and screening titles, abstracts, and full texts. Of these, five were found to be of poor methodological quality and 33 were of moderate quality. The most researched treatment methods were Endoluminal vacuum therapy (EVT), naso-fistula tube drainage (NFTD), and stent treatment. The success and mortality rates for EVT were 82% and 10.7%, for NFTD, 94% and 5.2%, and, for stent treatment, 75.1% and 13.5%, respectively. AL can be effectively treated with EVT, stent treatment, and NFTD. The NFTD approach appeared to have a higher success rate and lower mortality than other treatment modalities. However, it requires a longer treatment duration. Due to limitations within the included studies, a definitive recommendation regarding the optimal treatment for AL cannot be made.
C1 [Mucha, Andreas Weise; Strandby, Rune Broni; Nerup, Nikolaj Albeck; Achiam, Michael Patrick] Copenhagen Univ Hosp, Dept Surg & Transplantat, Rigshosp, Inge Lehmanns Vej 7, DK-2100 Copenhagen, Denmark.
   [Achiam, Michael Patrick] Univ Copenhagen, Dept Clin Med, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen
RP Mucha, AW (通讯作者)，Copenhagen Univ Hosp, Dept Surg & Transplantat, Rigshosp, Inge Lehmanns Vej 7, DK-2100 Copenhagen, Denmark.
EM andreas.weise.mucha.01@regionh.dk; rune.broni.strandby.01@regionh.dk;
   nikolaj.albeck.nerup@regionh.dk; Michael.Patrick.Achiam.01@regionh.dk
RI Achiam, Michael/ABA-1694-2020; Mucha, Andreas Weise/GZL-0021-2022
OI Mucha, Andreas Weise/0000-0002-9617-9521
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NR 62
TC 1
Z9 1
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1120-8694
EI 1442-2050
J9 DIS ESOPHAGUS
JI Dis. Esophagus
PD MAR 6
PY 2025
VL 38
IS 2
AR doaf016
DI 10.1093/dote/doaf016
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA Z3P0U
UT WOS:001438058800001
PM 40048658
DA 2026-07-24
ER
PT J
AU Mueller-Elmau, T
   Friess, H
AF Mueller-Elmau, Tara
   Friess, Helmut
TI Prevention and treatment of surgical site infections in abdominal
   surgery
SO CHIRURGIE
LA German
DT Article
DE Laparotomy; Risk factors; Preventive measures; Wound irrigation;
   Negative pressure wound therapy; Laparotomy; Risk factors; Preventive
   measures; Wound irrigation; Negative pressure wound therapy
ID WOUND-INFECTION; CONSENSUS; TRIAL
AB Postoperative surgical site infections after abdominal surgery are a relevant problem for patients and healthcare systems. Alongside pneumonia and urinary tract infections, surgical site infections are among the most common nosocomial infections in these patients. While the patient-related risk factors are mostly difficult to influence in the short-term, there are some modifiable, surgery-related risk factors (e.g., duration of surgery, sterile technique, blood loss) as well as various perioperative preventive measures with different evidence levels (e.g., skin disinfection, intravenous perioperative antibiotic prophylaxis, use of wound edge protectors, prophylactic wound irrigation, change of instruments and gloves before wound closure, triclosan-coated suture material, negative pressure dressing). Depending on the severity and depth of the infection, the treatment includes opening of the wound, surgical revision with fascial debridement/negative pressure wound therapy or the drainage of intra-abdominal abscesses and appropriate intravenous antibiotics. A relaparotomy for exploration and lavage is indicated in cases of generalized peritonitis.
C1 [Mueller-Elmau, Tara; Friess, Helmut] Univ Klinikum Tech Univ Munchen, Klin & Poliklin Chirurg, Klinikum rechts Isar, Ismaningerstr 22, D-81675 Munich, Germany.
C3 Technical University of Munich
RP Friess, H (通讯作者)，Univ Klinikum Tech Univ Munchen, Klin & Poliklin Chirurg, Klinikum rechts Isar, Ismaningerstr 22, D-81675 Munich, Germany.
EM helmut.friess@tum.de
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NR 41
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2731-6971
EI 2731-698X
J9 CHIRURGIE
JI Chirurgie
PD APR
PY 2025
VL 96
IS 4
SI SI
BP 347
EP 360
DI 10.1007/s00104-025-02242-x
EA MAR 2025
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 0NJ8D
UT WOS:001438958600001
PM 40047908
DA 2026-07-24
ER
PT J
AU Tanyildiz, M
   Özden,Ö
   Senköylü, K
   Eren, I
   Çakar, A
   Özbek, L
   Çakkalkurt, A
   Bilge, I
AF Tanyildiz, Murat
   Ozden, Omer
   Senkoylu, Karya
   Eren, Ilker
   Cakar, Aysu
   Ozbek, Lasin
   Cakkalkurt, Aslican
   Bilge, Ilmay
TI Should we give priority to plasma exchange and hyperbaric oxygen
   treatment before deciding on amputation for severe crush injuries?
SO TURKISH JOURNAL OF PEDIATRICS
LA English
DT Article
DE amputation; crush injury; hyperbaric oxygen treatment; therapeutic
   plasma exchange; pediatric protocol
AB Background. The most common medical sequelae after earthquakes are crush injuries and syndromes that require urgent and well-organized care, which further complicates the approach in the face of overstretched resources. The 2023 Kahramanmara & scedil;earthquake, with a magnitude of 7.7, was one of the largest disasters in T & uuml;rkiye, affecting 11 cities with a population of about 13.5 million people and claiming more than 50,000 deaths. Approximately 4.6 million pediatric patients were affected, with over 500 children undergoing amputations. The overwhelming number of cases rendered further treatment efforts nearly unfeasible. Cases. Here we present three cases of severe crush injuries in which amputation was initially considered in both primary and our tertiary centers but was prevented by a protocol that included therapeutic plasma exchange (TPE) and intensive hyperbaric oxygen treatments (HBOT). Based on our review of the literature, this appears to be the first case series documenting the use of therapeutic plasma exchange (TPE) in the management of crush injury. Conclusion. In extremities at risk for amputation, TPE therapy is crucial to preventing disseminated intravascular coagulation, systemic inflammatory response syndrome, and the accompanying multiorgan failure. It has been shown that extremities at risk for amputation due to poor perfusion can be managed confidently during the safe recovery period of daily TPE therapy with frequent HBOT, anticoagulant and vasodilator treatments, frequent wound care to prevent the development of infection, prophylactic antibiotics, vacuum-assisted closure therapy, and debridement when necessary.
C1 [Tanyildiz, Murat; Ozden, Omer; Senkoylu, Karya; Cakar, Aysu; Ozbek, Lasin] Koc Univ, Fac Med, Dept Pediat Intens Care, Istanbul, Turkiye.
   [Eren, Ilker] Koc Univ, Fac Med, Dept Orthoped & Traumatol, Istanbul, Turkiye.
   [Cakkalkurt, Aslican] Koc Univ Hosp, Dept Undersea & Hyperbar Med, Istanbul, Turkiye.
   [Bilge, Ilmay] Koc Univ, Fac Med, Dept Pediat Nephrol, Istanbul, Turkiye.
C3 Koc University; Koc University; Koc University; Koc University
RP Tanyildiz, M (通讯作者)，Koc Univ, Fac Med, Dept Pediat Intens Care, Istanbul, Turkiye.
EM murattanyildiz@gmail.com
RI ; tanyıldız, murat/IZP-6801-2023; Cakar, Aysu/KLC-5301-2024; ÖZDEN,
   ÖMER/LGZ-9822-2024; Eren, Ilker/C-7075-2018
OI ÇAKKALKURT, ASLICAN/0000-0002-9520-6225; tanyıldız,
   murat/0000-0001-8804-032X; Bilge, Ilmay/0000-0002-4852-989X; Cakar,
   Aysu/0009-0004-0510-4295; Şenköylü, Karya/0009-0009-0243-5925; ÖZDEN,
   ÖMER/0000-0003-0297-5250; Özbek, Laşin/0000-0002-2828-555X; Eren,
   Ilker/0000-0003-2965-7690
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   Millar IL, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008381
   Putzu A, 2019, ANESTHESIOLOGY, V131, P580, DOI 10.1097/ALN.0000000000002820
   Schottlender N, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11121827
   Sever MS, 2001, KIDNEY INT, V60, P1114, DOI 10.1046/j.1523-1755.2001.0600031114.x
   Turan RI, 2023, Anadolu AgencyMarch 3,
   Zannis J, 2009, ANN PLAS SURG, V62, P407, DOI 10.1097/SAP.0b013e3181881b29
NR 13
TC 1
Z9 1
U1 0
U2 0
PU TURKISH J PEDIATRICS
PI ANKARA
PA P K 66 SAMANPAZARI, 06240 ANKARA, Turkiye
SN 0041-4301
J9 TURKISH J PEDIATR
JI Turk. J. Pediatr.
PD JAN-FEB
PY 2025
VL 67
IS 1
BP 90
EP 100
DI 10.24953/turkjpediatr.2025.4577
PG 11
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA Z5K1Y
UT WOS:001439285200010
PM 40084732
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Xing, YH
   Hou, YL
   Li, C
   Wang, WF
   Fu, CJ
   Tang, L
AF Xing, Yihui
   Hou, Yali
   Li, Cui
   Wang, Weifeng
   Fu, Chongjian
   Tang, Lu
TI Analgesic effect of premixed nitrous oxide/oxygen on removal of vacuum
   assisted closure dressings: randomized controlled trial study protocol
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Nitrous oxide; Analgesia; Vacuum assisted closure; Procedure pain
ID PRESSURE WOUND THERAPY; DOUBLE-BLIND; PAIN; LIDOCAINE; SEDATION;
   QUALITY; IMPACT
AB BackgroundVacuum assisted closure (VAC) is an effective treatment that promotes wound healing in clinical practice. However, the pain caused by Vacuum assisted closure VAC dressing removal is still a challenge for patients and medical staff. The purpose of this study was to investigate the analgesic effect and safety of premixed nitrous oxide/oxygen in the treatment of pain caused by VAC dressing removal.Methods/designThis study is a single center, randomized, placebo-controlled, double-blind clinical trial. A total of 100 patients requiring VAC dressing removal were recruited and randomly divided into an intervention group and a control group. The intervention group will receive routine treatment plus a premixed nitrous oxide/oxygen mixture, and the control group will receive routine treatment plus oxygen. Participants and researchers are all blind to the operation process. The results of each group will be monitored at baseline (T0), 5 min after intervention (T1), and 5 min after finishing intervention (T2), 15 min after finishing intervention (T3). The primary outcome measure was pain intensity. Secondary outcomes included physiological parameters, adverse reactions, operators, and patients' satisfaction.DiscussionThis study will explore the analgesic effect of oxide/oxygen mixture on VAC dressing removal. If it is beneficial to patients with VAC dressing change, it will be helpful for pain management of VAC dressing removal.Trial registrationChinese Clinical Trial Register ChiCTR2200056742. Registered on February 13, 2022.
C1 [Xing, Yihui; Wang, Weifeng; Fu, Chongjian; Tang, Lu] 960th Hosp Peoples Liberat Army China PLA, Dept Stomatol, Jinan 250031, Peoples R China.
   [Xing, Yihui] Qingdao Stomatol Hosp, Qingdao, Peoples R China.
   [Hou, Yali] Shandong First Med Univ, Shandong Prov Hosp, Dept Stomatol, Jinan, Peoples R China.
   [Li, Cui] 960th Hosp PLA, Dept Rehabil, Jinan, Peoples R China.
   [Wang, Weifeng] Weifang Med Univ, Sch Nursing, Weifang, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong Second Medical University
RP Fu, CJ; Tang, L (通讯作者)，960th Hosp Peoples Liberat Army China PLA, Dept Stomatol, Jinan 250031, Peoples R China.
EM william68112002@aliyun.com; tanglu_office@163.com
RI wang, weifeng/N-4140-2013
FU Science and technology development project of Affiliated Hospital of
   Weifang Medical University
FX We thank our colleagues for their contributions in this experiment.
CR Bouri F, 2018, HEALTHCARE-BASEL, V6, DOI 10.3390/healthcare6030098
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NR 39
TC 0
Z9 0
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD MAR 4
PY 2025
VL 20
IS 1
AR 231
DI 10.1186/s13018-024-05397-1
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA Z5Z6V
UT WOS:001439687900004
PM 40038774
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chen, L
   Li, D
   Lei, XD
   Zhou, BX
   Chen, LL
AF Chen, Lan
   Li, Dong
   Lei, Xiaodong
   Zhou, Bixia
   Chen, Lili
TI Evaluation of the effect of a novel nursing intervention in the
   treatment of vacuum sealing drainage in patients with chronic orthopedic
   wounds
SO AFRICAN HEALTH SCIENCES
LA English
DT Article
DE Orthopedics; chronic wounds; pattern construction; vacuum sealing
   drainage; wound care
AB Background: To explore the application effect of "4+1" nursing intervention in the treatment of chronic orthopaedic trauma with negative pressure vacuum sealing drainage.
   Methodology: Patients before the implementation of the "4+1 nursing intervention" program were selected as the control group (60 cases). 60 patients after the implementation of the "4+1 nursing intervention" program were selected as the research group. Control group was given routine care. Research group adopted the "4+1" nursing intervention. Hamilton Depression score, wound healing time, pain visual analogue scale, treatment compliance, Self-Rating Anxiety Scale, and nursing satisfaction were compared between the two groups.
   Results: After the intervention, the Self-Rating Anxiety Scale and Hamilton Depression scores in the study group were lower than those in the control group; visual analogue scale on the 3rd and 5th days after the study were lower than those in the control group, and the wound healing time was shorter than that in the control group. The treatment compliance rate and nursing satisfaction of the study group were higher than those of the control group (P<0.05).
   Conclusion: The application of "4 + 1" nursing intervention in treatment of orthopaedic chronic wounds has a good effect.
C1 [Chen, Lan; Li, Dong; Lei, Xiaodong; Zhou, Bixia; Chen, Lili] Third Peoples Hosp Chengdu, Dept Orthoped, 82 Qinglong St, Chengdu 610031, Sichuan, Peoples R China.
RP Chen, LL (通讯作者)，Third Peoples Hosp Chengdu, Dept Orthoped, 82 Qinglong St, Chengdu 610031, Sichuan, Peoples R China.
EM cdsdsrmyygk@163.com
RI zhou, bixia/HTN-5864-2023
CR Bouetté G, 2021, CLIN NUTR, V40, P174, DOI 10.1016/j.clnu.2020.04.042
   Caffetti C, 2020, REUMATISMO, V72, P75, DOI 10.4081/reumatismo.2020.1271
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NR 15
TC 1
Z9 1
U1 0
U2 2
PU MAKERERE UNIV, COLL HEALTH SCIENCES,SCH MED
PI KAMPALA
PA PO BOX 7072, KAMPALA, 00000, UGANDA
SN 1680-6905
EI 1729-0503
J9 AFR HEALTH SCI
JI Afr. Health Sci.
PD DEC
PY 2024
VL 24
IS 4
DI 10.4314/ahs.v24i4.13
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Z7T4C
UT WOS:001440881400005
PM 40190495
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Di Micco, R
   Santurro, L
   Zuber, V
   Gasparri, ML
   Cisternino, G
   Ludovica, P
   Ceccarino, R
   Rottino, SA
   Forma, O
   Gentilini, OD
AF Di Micco, Rosa
   Santurro, Letizia
   Zuber, Veronica
   Gasparri, Maria Luisa
   Cisternino, Giovanni
   Ludovica, Pitoni
   Ceccarino, Raffaele
   Rottino, Stefano Antonio
   Forma, Ornella
   Gentilini, Oreste D.
TI Implant infection after prepectoral breast reconstruction treated with
   negative pressure wound therapy and photobiomodulation: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE breast implant; ductal breast carcinoma; infection; mastectomy; negative
   pressure wound therapy; photobiomodulation; prepectoral breast
   reconstruction; wound; wound care; wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; MANAGEMENT; SURGERY; SALVAGE;
   BIOMODULATION; METAANALYSIS; EFFICACY; DEVICE; REPAIR
AB Prepectoral breast reconstruction is a relatively new surgical technique that allows placement of the implant directly over the pectoralis major. It has benefits in terms of patient wellbeing, operative time, postoperative pain and recovery. However, in cases of infection, implant removal is often required and the patient is left with a flat chest. To the authors' knowledge, this is the first case of breast implant infection after breast reconstruction, successfully treated with a combination of both negative pressure wound therapy (NPWT) and photobiomodulation (PBM). A 32-year-old female patient with a sparing mastectomy for in situ ductal breast carcinoma followed by a prepectoral reconstruction. On the left side, the patient presented with dehiscence of 2.5cm with implant exposure 90 days after surgery. After an initial conservative approach, the patient's condition worsened, and she developed a larger dehiscence and a red breast. She was treated with implant removal. PBM of the cavity and the application of VeraFlo Therapy (3M, US) with a polyurethane-foam filling in the residual cavity were adopted. Pseudomonas aeruginosa was isolated and appropriate antibiotic therapy was started. Every 48-72 hours, she returned to the operating room for a washout, PBM, 21 days of this approach and two consecutive negative swabs, the patient underwent breast reconstruction with a subpectoral expander. After six months, a definitive implant of the same size as the contralateral one was positioned. The cosmetic result was good and patient satisfaction was high. The combination of NPWT and PBM may represent a good solution in case of breast implant infection after prepectoral reconstruction with benefits in terms of surgical outcome, patient satisfaction and postoperative quality of life. Declaration of interest: The authors have no conflicts of interest.
C1 [Di Micco, Rosa; Santurro, Letizia; Zuber, Veronica; Gasparri, Maria Luisa; Cisternino, Giovanni; Ludovica, Pitoni; Ceccarino, Raffaele; Rottino, Stefano Antonio; Gentilini, Oreste D.] IRCCS Osped San Raffaele, Breast Surg Unit, Milan, Italy.
   [Santurro, Letizia] Human Gavazzeni, Breast Surg, Via Mauro Gavazzeni Bergamo, Bergamo, Italy.
   [Gasparri, Maria Luisa] Ctr Senol Svizzera Italiana, Dept Gynecol & Obstet, Ente Ospedaliero Cantonale, Lugano, Switzerland.
   [Gasparri, Maria Luisa] Univ Italian Switzerland, Fac Biomed, Lugano, Switzerland.
   [Forma, Ornella] IRCCS Osped San Raffaele, Wound Care Unit, Milan, Italy.
   [Gentilini, Oreste D.] San Raffaele Vita Salute Univ, Milan, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Universita della Svizzera Italiana; Vita-Salute San Raffaele University;
   IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University
RP Di Micco, R (通讯作者)，IRCCS Osped San Raffaele, Breast Surg Unit, Milan, Italy.
EM dimicco.rosa@hsr.it
RI ; Di Micco, Rosa/AAC-3067-2019; Gentilini, Oreste/AAN-7577-2020
OI Pitoni, Ludovica/0000-0001-8462-8695; GASPARRI, Maria
   Luisa/0000-0002-9482-9527; 
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NR 55
TC 0
Z9 0
U1 1
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2025
VL 34
IS 3
BP 180
EP 186
DI 10.12968/jowc.2022.0097
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA Z9H4H
UT WOS:001441927700003
PM 40047824
DA 2026-07-24
ER
PT J
AU Wang, HN
   Song, ZM
   Xia, DY
   Tang, Q
   Wu, L
   Yu, LL
   Sun, XL
AF Wang, Huining
   Song, Zumei
   Xia, Dongyun
   Tang, Qian
   Wu, Ling
   Yu, Lili
   Sun, Xiaoling
TI Multidisciplinary approach to squamous cell carcinoma originating in
   hidradenitis suppurativa lesions: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hidradenitis suppurativa; inflammatory skin disease; multidisciplinary;
   negative pressure wound therapy; squamous cell carcinoma; wound; wound
   care; wound dressing; wound healing
AB Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease, and squamous cell carcinoma (SCC) is a rare complication of longstanding HS. In this case report, we describe the clinical management of a 30-year-old male patient with HS, with an eight-year history of a recurrent abscess and a nonhealing ulcer-like wound on his right buttock. The patient was also diagnosed with SCC originating from HS. A multidisciplinary team was established, comprising an oncologist, a plastic surgeon and two enterostomal therapists, to administer various treatments including chemotherapy, wound care, and surgical removal of lesions. The wound completely healed 201 days later, without any recurrence observed during follow-up. Declaration of interest: The authors have no conflicts of interest to declare.
C1 [Wang, Huining; Song, Zumei; Tang, Qian; Yu, Lili; Sun, Xiaoling] Nanjing Univ, Affiliated Hosp, Nanjing Drum Tower Hosp, Dept Jiangbei Outpatient,Med Sch, Nanjing, Jiangsu, Peoples R China.
   [Xia, Dongyun; Wu, Ling] Nanjing Univ, Nanjing Drum Tower Hosp, Wound Care Ctr, Affiliated Hosp,Med Sch, Nanjing, Jiangsu, Peoples R China.
C3 Nanjing University; Nanjing University
RP Sun, XL (通讯作者)，Nanjing Univ, Affiliated Hosp, Nanjing Drum Tower Hosp, Dept Jiangbei Outpatient,Med Sch, Nanjing, Jiangsu, Peoples R China.
EM sunxiaoling@nju.edu.cn
OI Wang, Huining/0009-0000-1500-9620
CR [Anonymous], 2017, Clin Cosmet Investig Dermatol, V10, P105, DOI [10.2147/CCID.S111019, DOI 10.2147/CCID.S111019]
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   Kohorst JJ, 2019, DERMATOL SURG, V45, P519, DOI 10.1097/DSS.0000000000001713
   Lee JH, 2018, J EUR ACAD DERMATOL, V32, P1784, DOI 10.1111/jdv.15071
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   Napolitano M, 2017, CLIN COSMET INV DERM, V10, P105, DOI 10.2147/CCID.S111019
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NR 14
TC 0
Z9 0
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2025
VL 34
IS 3
BP 196
EP 199
DI 10.12968/jowc.2023.0200
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA Z9H4H
UT WOS:001441927700005
PM 40047818
DA 2026-07-24
ER
PT J
AU Haas, E
   Garoosi, K
   Kalia, N
   Tin, G
   Lee, AN
   Orfahli, LM
   Mathes, DW
   Kaoutzanis, C
   Cohen, JB
AF Haas, Evan
   Garoosi, Kassra
   Kalia, Nargis
   Tin, Giovanni
   Lee, Anna
   Orfahli, Lynn M.
   Mathes, David W.
   Kaoutzanis, Christodoulos
   Cohen, Justin B.
TI Complications associated with abdominal incisional wound vacuum assisted
   closure following deep inferior epigastric perforator flap harvest for
   breast reconstruction: A single institution retrospective study
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Negative Pressure; Wound Therapy; Donor Site; Autologous Breast;
   Reconstruction; DIEP Flap
ID NEGATIVE-PRESSURE THERAPY; DONOR-SITE; DEHISCENCE; METAANALYSIS;
   MORBIDITY; DIEP
AB Background: The deep inferior epigastric perforator (DIEP) free flap reconstruction is a preferred breast reconstruction technique due to its muscle-sparing approach and patient satisfaction. However, donor-site complications, particularly wound dehiscence, remain a concern. Closed incision negative pressure wound therapy using wound vacuum assisted closure (VAC) systems may reduce these complications by enhancing perfusion and minimizing edema. This study evaluated the association between postoperative wound VAC use and complications in DIEP flap reconstruction. Methods: A retrospective cohort study was conducted at the University of Colorado, comparing the postoperative outcomes in patients who received closed incision negative pressure therapy (VAC) during DIEP flap reconstruction to those who did not (No VAC). Demographic and clinical characteristics, as well as 90-day abdominal complications, were compared between the cohorts. Statistical analyses included t-test, Wilcoxon rank-sum test, Chi-squared test, and multivariable logistic regression, with a p-value of <= 0.05 considered significant. Results: From 2021 to 2023, 302 patients were identified, with 114 (38%) receiving a wound VAC. The VAC group was older (mean age 53 +/- 10 vs. 50 +/- 10 years, p=0.03) and had longer operative times (534 +/- 108 vs. 495 +/- 110 min, p=0.003). No significant differences were observed in body mass index, ASA class, or most comorbidities. Complications such as hematoma, seroma, infection, wound dehiscence, bulge, hernia, ED visits, and readmissions showed no significant differences between the groups. Multivariable regression indicated a non-significant trend toward fewer complications with VAC use (adjusted OR 0.549, 95% CI 0.277-1.088, p=0.08). Conclusion: The use of incisional VAC did not significantly reduce abdominal complications following DIEP flap reconstruction. However, a nonsignificant trend toward fewer complications suggests that further investigation with larger, multi-institutional studies is warranted. (c) 2024 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.
C1 [Haas, Evan; Garoosi, Kassra; Kalia, Nargis; Tin, Giovanni; Lee, Anna; Orfahli, Lynn M.; Mathes, David W.; Kaoutzanis, Christodoulos; Cohen, Justin B.] Univ Colorado, Dept Surg, Div Plast & Reconstruct Surg, Anschutz Med Campus, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz
RP Cohen, JB (通讯作者)，Univ Colorado, Dept Surg, Div Plast & Reconstruct Surg, Anschutz Med Campus, Aurora, CO 80045 USA.
EM justin.b.cohen@cuanschutz.edu
RI ; Lee, Anna/NKP-8610-2025
OI Garoosi, Kassra/0000-0003-4925-6579; Haas, Evan/0000-0001-7953-7983;
   Lee, Anna/0000-0003-3566-8417
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NR 40
TC 7
Z9 7
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD APR
PY 2025
VL 103
BP 345
EP 350
DI 10.1016/j.bjps.2024.11.054
EA MAR 2025
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA Z9M6L
UT WOS:001442063800001
PM 40054295
DA 2026-07-24
ER
PT J
AU Dixon, JE
   Wellington, V
   Elnima, A
   Savers, A
   Ferreras, LAB
   Jalal, AR
   Eltaher, HM
AF Dixon, James E.
   Wellington, Vanessa
   Elnima, Alaa
   Savers, Amelie
   Ferreras, Lia A. Blokpoel
   Jalal, Aveen R.
   Eltaher, Hoda M.
TI Enhanced localized pressure-mediated non-viral gene delivery
SO DRUG DELIVERY AND TRANSLATIONAL RESEARCH
LA English
DT Article
DE GAG-binding <underline>e</underline>nhanced
   <underline>t</underline>ransduction (GET); Negative pressure wound
   therapy; Gene transfer; Transfection; Skin
ID CELL-PENETRATING PEPTIDES; PORE-SIZE; IN-VITRO; THERAPY; PROTEIN;
   TRANSDUCTION; FORMULATION; CHALLENGES; SCAFFOLDS; DNA
AB Topically applied therapies must not only be effective at the molecular level but also efficiently access the target site which can be on milli/centimetre-scales. This bottleneck is particularly inhibitory for peptide and nucleic acid macromolecule drug delivery strategies, especially when aiming to target wounded, infected, and poorly perfused tissues of significant volume and geometry. Methods to drive fluid-flow or to enhance physical distribution of such formulations after local administration in accessible tissues (skin, eye, intestine) would be transformative in realizing the potential of such therapeutics. We previously developed a technology termed Glycosaminoglycan (GAG)-binding enhanced transduction (GET) to efficiently deliver a variety of cargoes intracellularly, using GAG-binding peptides and cell penetrating peptides (CPPs) in the form of nanoparticles. Herein, we demonstrate that the most simplistic GET formulation is relatively poor in diffusing into tissue matrix (tested in collagen scaffolds). Changing nanoparticle physicochemical properties can enhance penetration, however the use of a pressure differential, generating fluid-flow significantly enhances effective gene delivery over milli/centimetre scales. We adapted clinically used pressure systems to administer both negative (Negative pressure (NP) wound therapy; NPWT) and positive pressures (PP; Insufflator). Pressure differences generated enhanced distribution, and we were able to show for the first-time localized gene transfer in vitro in cell scaffolds and enhanced transfection of ex vivo skin explants. The ability to simply control intra-tissue localization of gene delivery on milli/centimetre scales using pressure application will facilitate new drug delivery strategies for accessible tissues. Importantly site-specific enhancement of penetration and activity of novel nanotechnologies and gene therapeutics could be transformative for future regenerative medicine strategies.
C1 [Dixon, James E.; Wellington, Vanessa; Elnima, Alaa; Savers, Amelie; Ferreras, Lia A. Blokpoel; Jalal, Aveen R.; Eltaher, Hoda M.] Univ Nottingham, Biodiscovery Inst BDI, Sch Pharm, Regenerat Med & Cellular Therapies Div, Nottingham NG7 2RD, England.
   [Dixon, James E.] Univ Nottingham, NIHR Nottingham Biomed Res Ctr, Nottingham NG7 2RD, England.
C3 University of Nottingham; University of Nottingham
RP Dixon, JE (通讯作者)，Univ Nottingham, Biodiscovery Inst BDI, Sch Pharm, Regenerat Med & Cellular Therapies Div, Nottingham NG7 2RD, England.; Dixon, JE (通讯作者)，Univ Nottingham, NIHR Nottingham Biomed Res Ctr, Nottingham NG7 2RD, England.
EM james.dixon@nottingham.ac.uk
RI M. Eltaher, Hoda/AAO-6116-2020
OI M. Eltaher, Hoda/0000-0001-5602-2696; Dixon, James/0000-0003-1225-3825
FU Defence Science and Technology Laboratory
FX Not applicable
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NR 60
TC 0
Z9 0
U1 2
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2190-393X
EI 2190-3948
J9 DRUG DELIV TRANSL RE
JI Drug Deliv. Transl. Res.
PD OCT
PY 2025
VL 15
IS 10
BP 3679
EP 3694
DI 10.1007/s13346-025-01827-7
EA MAR 2025
PG 16
WC Instruments & Instrumentation; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Instruments & Instrumentation; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 7CV1L
UT WOS:001442993200001
PM 40072728
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Anestiadou, E
   Stamiris, S
   Ioannidis, O
   Symeonidis, S
   Bitsianis, S
   Bougioukas, K
   Karagiannis, T
   Kotidis, E
   Pramateftakis, MG
   Mantzoros, I
   Cheva, A
   Geropoulos, G
   Chatzianestiadou, C
   Kaprianou, M
   Tserkezidis, F
   Angelopoulos, S
AF Anestiadou, Elissavet
   Stamiris, Stavros
   Ioannidis, Orestis
   Symeonidis, Savvas
   Bitsianis, Stefanos
   Bougioukas, Konstantinos
   Karagiannis, Thomas
   Kotidis, Efstathios
   Pramateftakis, Manousos-Georgios
   Mantzoros, Ioannis
   Cheva, Angeliki
   Geropoulos, Georgios
   Chatzianestiadou, Christiana
   Kaprianou, Magdalini
   Tserkezidis, Freiderikos
   Angelopoulos, Stamatios
TI Comparison of Negative Pressure Wound Therapy Systems and Conventional
   Non-Pressure Dressings on Surgical Site Infection Rate After Stoma
   Reversal: Systematic Review and Meta-Analysis of Randomized Controlled
   Trials
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE Negative Pressure Wound Therapy (NPWT); Surgical Site Infections (SSI);
   stoma reversal; meta-analysis; Randomized Controlled Trials (RCTs);
   colorectal surgery
ID CLOSURE; PREVENTION; OUTCOMES
AB Background/Objectives: Surgical Site Infections (SSIs) rank among the most common complications following stoma takedown and lead to increased morbidity, increased Length of Hospital Stay (LOS), and higher healthcare costs. Negative Pressure Wound Therapy (NPWT) systems have emerged as a promising option for optimizing wound management and minimizing SSI rates. This systematic review and meta-analysis compares postoperative outcomes of NPWT and conventional Non-Pressure Dressings following stoma reversal. Methods: A search of the literature published up to 1 September 2024 was conducted across MEDLINE/PubMed, and the Cochrane Central Register of Controlled Trials (CENTRAL), and Scopus, as well as ClinicalTrials.gov. Only Randomized Controlled Trials (RCTs) were included. The primary outcome was SSI rate, while secondary outcomes included time to complete wound healing, LOS, and patient-reported wound cosmesis. Quality assessment was performed using the Cochrane Risk of Bias 2 (RoB 2) tool. The results were synthesized using means and Standard Deviations for continuous variables, counts and percentages for categorical variables, and presented as Odds Ratios (OR) or Mean Differences (MD) with 95% Confidence Intervals, using random or fixed effects models based on heterogeneity (I2). Results: Six RCTs, including 328 patients, were ultimately eligible for inclusion. No significant difference was revealed in SSI rates between the NPWT and conventional dressing groups (OR = 0.95; 95% CI: 0.27-3.29; p = 0.94; I2 = 38%). Time to complete wound healing was significantly lower in the NPWT group compared to conventional dressings (MD = -3.78 days; 95% CI: -6.29 to -1.27; p = 0.003). Two studies reported a lower rate of wound healing complications other than SSIs in the NPWT group (OR = 0.22; 95% CI: 0.05-1.09; p = 0.06). No substantial differences were observed in terms of LOS (MD = -0.02 days; 95% CI: -1.22 to 1.17; p = 0.97) and patient-reported wound cosmesis (SMD = 0.31; 95% CI: -0.49 to 1.11; p = 0.44). The review's limitations include potential risk of bias, variability in study designs, and heterogeneity between studies. Conclusions: NPWT contributes to improved wound management through reducing wound healing time compared to Non-Pressure Dressings after stoma reversal, although it does not appear to substantially impact SSI rates, LOS, or patient-assessed wound cosmesis. Further large-scale, multicenter RCTs are necessary to validate these results and identify patient populations most likely to benefit from NPWT application.
C1 [Anestiadou, Elissavet; Ioannidis, Orestis; Symeonidis, Savvas; Bitsianis, Stefanos; Kotidis, Efstathios; Pramateftakis, Manousos-Georgios; Mantzoros, Ioannis; Chatzianestiadou, Christiana; Kaprianou, Magdalini; Tserkezidis, Freiderikos; Angelopoulos, Stamatios] Aristotle Univ Thessaloniki, Gen Hosp George Papanikolaou, Dept Surg 4, Exochi 57010, Greece.
   [Stamiris, Stavros] 424 Gen Mil Hosp, Orthopaed Dept, Ring Rd West, Thessaloniki 56429, Greece.
   [Bougioukas, Konstantinos] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Dept Hyg Social Prevent Med & Med Stat, Thessaloniki 54124, Greece.
   [Karagiannis, Thomas] Aristotle Univ Thessaloniki, Med Dept 2, Clin Res & Evidence Based Med Unit, Thessaloniki 54642, Greece.
   [Cheva, Angeliki] Aristotle Univ Thessaloniki, Fac Med, Pathol Dept, Thessaloniki 54124, Greece.
   [Geropoulos, Georgios] West Hertfordshire Teaching Hosp, Watford Gen Hosp, Dept Gen Surg, Watford WD180DH, England.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Aristotle University of Thessaloniki; Aristotle University
   of Thessaloniki; Watford General Hospital
RP Ioannidis, O (通讯作者)，Aristotle Univ Thessaloniki, Gen Hosp George Papanikolaou, Dept Surg 4, Exochi 57010, Greece.
EM elissavetxatz@gmail.com; st.stamiris@hotmail.com; telonakos@hotmail.com;
   simeonidissavvas@yahoo.com; sbitsiani@gmail.com; kbugiuk@yahoo.com;
   tkaragian@auth.gr; skotidis@gmail.com; mpramateftakis@hotmail.com;
   imanvol@gmail.com; antacheva@auth.gr; geropoulosgeo@gmail.com;
   cchristia@auth.gr; magdarenos@yahoo.gr; frtserkezidis@gmail.com;
   saggelopoulos@auth.gr
RI Cheva, Angeliki/HGB-6685-2022; Bitsianis, Stefanos/PLC-1440-2026;
   Bougioukas, Konstantinos/ABE-7673-2020; Karagiannis, Thomas/H-9476-2019;
   Stamiris, Stavros/JMB-4170-2023
OI Anestiadou, Elissavet/0000-0001-5650-7319; Bougioukas,
   Konstantinos/0000-0002-6533-1391; TSERKEZIDIS,
   FREIDERIKOS/0009-0009-8888-9740; Bitsianis,
   Stefanos/0000-0001-8281-1189; Karagiannis, Thomas/0000-0001-5242-0574;
   Ioannidis, Orestis/0000-0002-0861-8783; Stamiris,
   Stavros/0000-0001-8543-6791
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NR 63
TC 8
Z9 9
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2025
VL 14
IS 5
AR 1654
DI 10.3390/jcm14051654
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0BM8R
UT WOS:001443427800001
PM 40095625
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kerivan, LT
   Vilain, KA
   Hill, TM
   Guidry, CA
AF Kerivan, Lauren T.
   Vilain, Katherine A.
   Hill, Terra M.
   Guidry, Christopher A.
TI Closed Incisional Negative Pressure Wound Therapy is Cost-Effective at
   Reducing Superficial Surgical Site Infections
SO SURGICAL INFECTIONS
LA English
DT Article
DE cost-effectiveness; decision analysis; negative-pressure wound therapy;
   prevention; surgical site infections
ID AMERICAN-COLLEGE; DRESSINGS; TRAUMA
AB Background: Surgical site infections (SSIs) have a significant health economic burden, accounting for more than US $3.3 billion in costs, and lead to increased microbial resistance, prolonged hospital stays, elevated 30-day mortality rates, greater incidences of reoperation, and decreased quality of life. Recently, evidence has emerged suggesting that prophylactic closed incision negative pressure wound therapy (ciNPWT) may substantially reduce the risk of post-operative wound complications, specifically SSIs. This study aimed to evaluate whether ciNPWT is cost-effective compared with routine incision care for the prevention of superficial SSIs.Hypothesis: We hypothesized that ciNPWT is cost-effective compared with routine incision care for the prevention of superficial SSIs.Methods: A cost-effectiveness decision analytic model was created comparing the use and non-use of ciNPWT. Superficial SSI probabilities, cost of care for patients with and without post-operative infection, and quality of life Short Form (SF)-36 survey data were obtained from a literature review. Cost of ciNPWT was obtained from health administrative data. A decision tree was constructed using TreeAge Software Pro Version 2020 (TreeAge Software, Inc., Williamstown, MA). Deterministic and probabilistic sensitivity analyses were performed to evaluate the robustness and reliability of the model.Results: One-way sensitivity analysis with a willingness-to-pay threshold of $5,000 demonstrated that above a baseline infection rate of approximately 6.4%, ciNPWT is cost-effective at reducing superficial SSI. Probabilistic sensitivity analysis indicated that even with uncertainty present in the parameters analyzed, the majority of simulations (95.4%) favored ciNPWT as the more effective tactic.Conclusions: Despite the added device cost, ciNPWT is cost-effective for superficial SSI prevention across a variety of surgical infection risk profiles.
C1 [Kerivan, Lauren T.; Hill, Terra M.; Guidry, Christopher A.] Univ Kansas Med Ctr, Dept Surg, Kansas City, KS 66103 USA.
   [Vilain, Katherine A.] St Lukes Hosp Cardiovasc & Cardiothorac Res, Kansas City, MO USA.
C3 University of Kansas; University of Kansas Medical Center
RP Guidry, CA (通讯作者)，Univ Kansas Med Ctr, Dept Surg, Kansas City, KS 66103 USA.
EM cguidry2@kumc.edu
RI Kerivan, Lauren/NBX-4693-2025; Guidry, Christopher/GRS-5109-2022
OI Kerivan, Lauren/0009-0002-7648-2678; 
CR Acker A, 2018, J SURG RES, V232, P450, DOI 10.1016/j.jss.2018.05.083
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NR 35
TC 2
Z9 2
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD AUG 1
PY 2025
VL 26
IS 6
BP 413
EP 419
DI 10.1089/sur.2024.286
EA MAR 2025
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA 5PZ8Z
UT WOS:001447449600001
PM 40106232
DA 2026-07-24
ER
PT J
AU Drumm, C
   Creavin, B
   Previsic, IP
   O'Neill, M
   Larkin, J
   Mehigan, BJ
   Kavanagh, D
   Mccormick, P
   Kelly, ME
AF Drumm, Caroline
   Creavin, Ben
   Previsic, Iva Pranjic
   O'Neill, Maeve
   Larkin, John
   Mehigan, Brian J.
   Kavanagh, Dara
   Mccormick, Paul
   Kelly, Michael Eamon
TI The use of negative pressure wound therapy following stoma reversal: a
   systematic review and meta-analysis of randomized controlled trials
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Negative pressure; NPWT; Stoma reversal; Colorectal surgery
ID SURGICAL SITE INFECTION; CLOSURE
AB IntroductionStoma reversal is a contaminated surgery with many patients experiencing significant wound complications that contribute to patient morbidity. It is believed that the use of prophylactic negative pressure wound therapy (NPWT) may enhance wound healing and help reduce the risk of developing surgical site infections (SSI). However, there is conflicting research regarding its effectiveness following stoma reversal. Our systematic review aims to evaluate the available randomized data to determine if the use of prophylactic NPWT after stoma reversal improves the duration of wound healing and reduces rates of postoperative complications.MethodsA comprehensive search of literature published up to January 2025 was conducted using the following databases: PubMed, Embase, Medline, and Cochrane Library. The included trials were randomized controlled trials that investigated the effect of NPWT following stoma reversal. The primary outcome was the time to complete wound healing. Secondary outcomes included the incidence of wound complications, SSI, hematomas, and the length of hospital stay.ResultsSix randomised control trials were included, with 332 patients, of which 171 of these underwent NPWT. There was a significant reduction in time to complete wound healing (OR - 2.53, 95% CI - 3.82 to - 1.24, p = 0.0001, I2 = 45%) and wound healing at 42 days (OR 0.36, 95% CI 0.14 - 0.88, p = 0.03, I2 = 0%) in the NPWT group. There was no significant difference in any wound complications (OR 0.72, 95% CI 0.23-2.28, p = 0.58, I2 = 42%), SSI rates (OR 0.95, 95% CI 0.27-3.29, p = 0.94, I2 = 38%) or haematoma rates (OR 0.21, 95% CI 0.03-1.27, p = 0.09, I2 = 0%) between the groups. There was no significant difference in length of stay (OR - 0.02, 95% CI - 1.21-1.18, p = 0.98, I2 = 66%).ConclusionThe use of NPWT after stoma reversal significantly reduces the time needed for complete wound healing while maintaining a comparable rate of wound complications and length of hospital stay. Therefore, NPWT may be valuable in optimizing postoperative recovery and enhancing patient outcomes.
C1 [Drumm, Caroline; Creavin, Ben; Previsic, Iva Pranjic; O'Neill, Maeve; Larkin, John; Mehigan, Brian J.; Mccormick, Paul; Kelly, Michael Eamon] St James Hosp, Dept Surg, Dublin, Ireland.
   [Kavanagh, Dara] Tallaght Univ Hosp, Dept Surg, Dublin, Ireland.
C3 Trinity College Dublin
RP Kelly, ME (通讯作者)，St James Hosp, Dept Surg, Dublin, Ireland.
EM Kellym11@tcd.ie
FU IReL Consortium
FX Open Access funding provided by the IReL Consortium.
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NR 22
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD MAR 20
PY 2025
VL 40
IS 1
AR 73
DI 10.1007/s00384-025-04865-2
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 0IZ4Z
UT WOS:001448512600001
PM 40111521
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Nattrodt, JJM
   Bezerra-de-Freitas, VA
   Merval, APSS
   Filardi, ET
   Cerni, FA
   Dantas, DSM
   Lins, ABM
   Galan, LEB
   Carbonell, RC
   Pucca, MB
AF Nattrodt, Janio J. M.
   Bezerra-de-Freitas, Victoria A.
   Merval, Ana Paula S. S.
   Filardi, Eloise T.
   Cerni, Felipe A.
   Dantas, Domingos S. M.
   Lins, Alysson B. M.
   Galan, Luis E. B.
   Carbonell, Roberto C.
   Pucca, Manuela B.
TI Case report: Clinical management of freshwater stingray wounds using
   negative pressure therapy
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE ichthyism; stingray accident; stingray management; epidemiology; Amazon
ID SECONDARY INTENTION
AB Stingray injuries represent a significant occupational hazard, particularly for fishermen, and are commonly caused by freshwater stingrays of the Potamotrygonidae family. These stingrays are equipped with a sharp, bilaterally serrated spine that delivers venom, inducing vasoconstriction, severe pain, and ischemia. Such injuries are not only intensely painful but also debilitating, often rendering victims unable to work for weeks or even months. Traditional self-treatment practices, including the application of urine and herbal remedies, are widely relied upon in affected communities but are scientifically unproven and frequently lead to delayed or suboptimal care. This study presents two clinical cases of freshwater stingray envenomation from Roraima, the northernmost state of Brazil located within the Amazon Rainforest. Both cases were managed at the infectious disease unit of the General Hospital in Boa Vista, the state capital. Patients received evidence-based medical care, including intravenous antibiotic therapy and surgical debridement to remove necrotic and devitalized tissue. In one case, advanced negative pressure wound therapy (NPWT) was utilized during dressing changes, resulting in a clean wound devoid of edema and necrotic tissue, demonstrating the technique's effectiveness in promoting wound healing. By accelerating wound healing and mitigating complications such as infections and chronic wounds, NPWT significantly enhance patient outcomes. Furthermore, this study underscores the limitations of traditional remedies and advocates for the adoption of evidence-based interventions, particularly in regions like the Brazilian Amazon, where access to healthcare can be challenging.
C1 [Nattrodt, Janio J. M.; Lins, Alysson B. M.; Galan, Luis E. B.; Carbonell, Roberto C.] Gen Hosp Roraima, Boa Vista, Brazil.
   [Bezerra-de-Freitas, Victoria A.; Cerni, Felipe A.; Lins, Alysson B. M.; Galan, Luis E. B.; Carbonell, Roberto C.] Fed Univ Roraima UFRR, Med Sch, Boa Vista, Brazil.
   [Merval, Ana Paula S. S.] Fed Univ Roraima UFRR, Grad Program Hlth & Sci PROCISA, Boa Vista, Brazil.
   [Filardi, Eloise T.; Pucca, Manuela B.] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Grad Program Biosci & Biotechnol Appl Pharm, Araraquara, Brazil.
   [Dantas, Domingos S. M.] Fac Med Porto, Programa Doutoral Bioet, Porto, Portugal.
   [Pucca, Manuela B.] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, Brazil.
C3 Universidade Federal de Roraima; Universidade Federal de Roraima;
   Universidade Estadual Paulista; Universidade do Porto; Universidade
   Estadual Paulista
RP Carbonell, RC (通讯作者)，Gen Hosp Roraima, Boa Vista, Brazil.; Carbonell, RC (通讯作者)，Fed Univ Roraima UFRR, Med Sch, Boa Vista, Brazil.; Pucca, MB (通讯作者)，Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Grad Program Biosci & Biotechnol Appl Pharm, Araraquara, Brazil.; Pucca, MB (通讯作者)，Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, Brazil.
EM rcccarbonell@yahoo.es; manuela.pucca@unesp.br
RI Pucca, Manuela/IUQ-1517-2023
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2024/13258-0, 2024/01801-1]; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) [305778/2023-4]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. We thank
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP;
   scholarship to E.T.F. No. 2024/13258-0 and M.R. No. 2024/01801-1),
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq,
   scholarship to M.P. No. 305778/2023-4).
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
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   Terapia de Feridas com Pressao Negativa, Uma Revisao de Seu Uso em Trauma Ortopedico
   Zaver V., 2025, Negative pressure wound therapy
NR 27
TC 1
Z9 2
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 10
PY 2025
VL 12
AR 1536540
DI 10.3389/fmed.2025.1536540
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0LX9A
UT WOS:001450505600001
PM 40130256
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Manterola, C
   Rivadeneira, J
   Holguín, JP
   García, MF
   Munoz, G
AF Manterola, Carlos
   Rivadeneira, Josue
   Holguin, Juan Pablo
   Garcia, Maria Fernanda
   Munoz, Georgina
TI Open Abdomen. Overall Review of the Evidence
SO INTERNATIONAL JOURNAL OF MORPHOLOGY
LA English
DT Article
DE Open abdomen techniques; Abdominal traumainjuries; Intraabdominal
   infections; Negative-Pressure wound detherapy; Fascial closure; Vacuum
   sealing drainage; Vacuum- deassisted closure
ID PRESSURE WOUND THERAPY; TEMPORARY ABDOMINAL CLOSURE; DAMAGE-CONTROL
   LAPAROTOMY; PRIMARY FASCIAL CLOSURE; INTRAABDOMINAL PRESSURE;
   ABBREVIATED LAPAROTOMY; COMPARTMENT SYNDROME; MARLEX MESH; MANAGEMENT;
   QUALITY
AB The open abdomen (OA) is a technical innovation that has enhanced the surgical understanding of damage control surgery (DCS), temporary abdominal closure, staged abdominal reconstruction, visceral care, and abdominal wal reconstruction. The aim of this study was to report the existing evidence on the use of OA in patients with intra-abdominalBjarnason, hypertension (IAH), abdominal compartment syndrome (ACS), DCS for trauma, and the prevention and treatment of IAH and ACS. overview was conducted. Primary or secondary articles evaluating the outcomes of OA in adults, for septic or traumatic indications, published between 2010 and 2023 were considered. The following meta-search engines, libraries, and databases were reviewed: Database, BIREME-BVS, SciELO, Cochrane Central Register Controlled Trials, WoS, MEDLINE, EMBASE, and SCOPUS. Risk of bias assessment was applied using the SIGN design. Subsequently, the levels of evidence were classified according to the Oxford CEBM proposal. Methodological quality (MQ) was determined using AMSTAR 2 for systematic reviews (SR), modified Jadad for clinical trials (CT), and MInCir-T for observational studies (OS) and therapy related CT. Finally, the evidence was graded using the GRADE system. A total of 33 studies were analyzed (9 SR, 3 CT, and 21 OS, representing a population of 26,519 patients with O A). In subjects with OA due to IAH, the evidence regarding morbidity and mortality is scarce and heterogeneous. In adults with abdominal trauma OA, better outcomes are observed when negative pressure closure techniques are applied compared to passive temporary closure. existing evidence to recommend commercial devices over homemade devices is weak. Systematic and routine measurement of intraabdominal pressure would be justified as a method for detecting and ACS in patients with OA due to IAH or trauma. The available relaci & oacute;nevidence regarding the effectiveness of OA techniques in patients datoswith trauma and IAH in the presented situations is based on a few y studies, mostly of low MQ. Therefore, new high-quality comparative studies with an adequate number of patients are needed to clarify estudio. current uncertainty.
C1 [Manterola, Carlos; Rivadeneira, Josue; Holguin, Juan Pablo; Garcia, Maria Fernanda; Munoz, Georgina] Univ La Frontera, Programa Doctorado Ciencias Med, Temuco, Chile.
   [Manterola, Carlos] Univ La Frontera, Ctr Estudios Morfol & Quirurg CEMyQ, Temuco, Chile.
   [Holguin, Juan Pablo; Munoz, Georgina] Univ Azuay, Cuenca, Ecuador.
   [Garcia, Maria Fernanda] Univ Cent Ecuador, Quito, Ecuador.
C3 Universidad de La Frontera; Universidad de La Frontera; Universidad del
   Azuay; Universidad Central del Ecuador
RP Manterola, C (通讯作者)，Univ La Frontera, Programa Doctorado Ciencias Med, Francisco Salazar 01145, Temuco, Chile.; Manterola, C (通讯作者)，Univ La Frontera, CEMyQ, Francisco Salazar 01145, Temuco, Chile.
EM carlos.manterola@ufrontera.cl
RI Manterola, Carlos/F-8826-2013; Holguín C, Juan Pablo/HJP-5829-2023;
   García-Aguilera, María Fernanda/MGW-6733-2025; Rivadeneira,
   Josue/QJV-7394-2026
OI Holguín C, Juan Pablo/0000-0002-6844-3962; García-Aguilera, María
   Fernanda/0000-0002-5375-3474; 
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NR 86
TC 0
Z9 0
U1 0
U2 0
PU SOC CHILENA ANATOMIA
PI TEMUCO
PA CASILLA 54-D, TEMUCO, 00000, CHILE
SN 0717-9502
EI 0717-9367
J9 INT J MORPHOL
JI Int. J. Morphol.
PD FEB
PY 2025
VL 43
IS 1
BP 275
EP 293
PG 19
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA 0MA8W
UT WOS:001450583300036
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Qiu, LZ
   Wu, XR
   Wang, X
AF Qiu, Liangzhi
   Wu, Xianrong
   Wang, Xiu
TI Application of Negative-Pressure Wound Therapy in Patients with Wound
   Complications after Flap Repair for Vulvar Cancer: A Retrospective Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE flap repair; negative-pressure wound therapy; vulvar cancer; vulvectomy;
   wound complication; wound healing
ID VACUUM-ASSISTED CLOSURE; GUIDELINES; MANAGEMENT; INFECTION
AB OBJECTIVETo analyze the characteristics of postoperative wound complications (WCs) in patients following vulvectomy with flap repair and evaluate the efficacy of negative-pressure wound therapy (NPWT) in wound healing.METHODSThis study retrospectively reviewed 17 patients with WCs following vulvectomy with flap repair at a tertiary comprehensive hospital from January 2016 to December 2022. All patients were treated with NPWT, and the wound healing rate, healing time, and NPWT-related complications were observed.RESULTSThe most common WCs were seroma and lymphorrhea (52.94%; nine cases), followed by wound infection (35.29%, six cases), fat liquefaction (23.53%, four cases), wound dehiscence (17.65%, three cases), and wound ischemia (5.88%, one case). The main locations for flap WCs were the vulva (64.71%), thigh (35.29%), and pubic symphysis (23.53%). One patient halted treatment; the remaining 16 patients all achieved complete healing with a mean healing time of 43.50 +/- 17.92 days. One complication was associated with the use of NPWT: procedural pain (17.65%, three cases).CONCLUSIONSThe use of NPWT may contribute to accelerated wound healing after flap repair in vulvar cancer and is safe for clinical application.
C1 [Qiu, Liangzhi; Wu, Xianrong; Wang, Xiu] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Wound Ostomy & Continence Chron Wound & Ostomy Dep, Guangzhou, Peoples R China.
C3 Sun Yat Sen University
RP Qiu, LZ (通讯作者)，Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Wound Ostomy & Continence Chron Wound & Ostomy Dep, Guangzhou, Peoples R China.
EM qiulzhi@mail2.sysu.edu.cn; 772029778@qq.com; wangxiu.whu@qq.com
RI Wu, xianrong/NAX-7315-2025
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NR 31
TC 2
Z9 2
U1 3
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD APR
PY 2025
VL 38
IS 3
BP 142
EP 147
DI 10.1097/ASW.0000000000000247
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 0MA9R
UT WOS:001450585400007
PM 39666827
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Ahmic, E
   Swatek, P
   Mykoliuk, I
   Busau, A
   Bamberg, P
   Smolle, J
   Smolle-Juettner, FM
   Lindenmann, J
AF Ahmic, Edin
   Swatek, Paul
   Mykoliuk, Iurii
   Busau, Anton
   Bamberg, Paul
   Smolle, Josef
   Smolle-Juettner, Freyja Maria
   Lindenmann, Jorg
TI Management and Outcomes of Sternoclavicular Joint Infections: A
   Retrospective Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE sternoclavicular joint infection; muscle flap reconstruction; chest
   wall; negative pressure wound therapy; sternum infection
ID PROPIONIBACTERIUM-ACNES; SURGICAL-MANAGEMENT; SEPTIC ARTHRITIS
AB Introduction: Sternoclavicular joint infections (SCJIs) are extremely rare, making up less than 1% of all septic arthritis cases. This retrospective study aims to evaluate the management and outcomes of SCJIs, including both surgical and non-surgical approaches. Methods: This retrospective study included 55 patients treated between January 2005 and December 2023 at the Division of Thoracic and Hyperbaric Surgery in Graz, Austria. Data on patient characteristics, treatment approach, and outcome were analyzed. Results: Out of the 55 patients, 50 (90.91%) underwent surgery. Among them, 21 (38.18%) had pleural involvement and 9 (16.36%) developed sepsis. Primary debridement and sternoclavicular joint resection with muscle flap closure were performed in 5 patients (9.3%), whilst debridement and negative pressure wound therapy (NPWT) followed by joint resection were applied in 32 patients (59.3%). In total, 15 (27.2%) of these cases required a secondary muscle flap. Positive cultures were found in 35 patients (63.64%), with Staphylococcus aureus being the most common pathogen. Multivariate analysis identified elevated CRP and leukocyte levels as significant predictors of sepsis. Defects requiring myoplastic procedures were associated with a higher risk of complications, sepsis, and prolonged hospital stays. Postoperative complications occurred in 20 patients (36.36%), but there was no 30-day mortality. Conclusions: SCJI is a rare but serious condition that requires prompt surgical intervention. Our findings suggest that combining surgical resection with NPWT and/or myocutaneous flap techniques is effective. Close monitoring of inflammatory markers is crucial for identifying sepsis risk and improving patient outcomes.
C1 [Ahmic, Edin; Swatek, Paul; Mykoliuk, Iurii; Busau, Anton; Bamberg, Paul; Smolle-Juettner, Freyja Maria; Lindenmann, Jorg] Med Univ Graz, Dept Surg, Div Thorac & Hyperbar Surg, A-8036 Graz, Austria.
   [Smolle, Josef] Med Univ Graz, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria.
C3 Medical University of Graz; Medical University of Graz
RP Ahmic, E (通讯作者)，Med Univ Graz, Dept Surg, Div Thorac & Hyperbar Surg, A-8036 Graz, Austria.
EM edin.ahmic@medunigraz.at; paul.swatek@medunigraz.at;
   iurii.mykoliuk@medunigraz.at; anton.busau@medunigraz.at;
   paul.bamberg@stud.medunigraz.at; josef.smolle@medunigraz.at;
   freyja.smolle@medunigraz.at; jo.lindenmann@medunigraz.at
OI Swatek, Paul Thomas/0009-0008-8062-0918; Bamberg,
   Paul/0009-0000-2493-8069; Smolle-Juettner,
   Freyja-Maria/0000-0002-0875-0821; Smolle, Josef/0000-0002-8005-4660;
   Lindenmann, Joerg/0000-0003-1276-7666; Ahmic, Edin/0009-0006-8358-4225
CR Abu Arab W, 2011, EUR J CARDIO-THORAC, V40, P630, DOI 10.1016/j.ejcts.2010.12.037
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NR 26
TC 1
Z9 2
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR 11
PY 2025
VL 14
IS 6
AR 1893
DI 10.3390/jcm14061893
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0QA0I
UT WOS:001453273400001
PM 40142700
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kuromaru, Y
   Won, P
   Madrigal, P
   Choe, D
   Gillenwater, TJ
AF Kuromaru, Yuki
   Won, Paul
   Madrigal, Paloma
   Choe, Deborah
   Gillenwater, T. Justin
TI Negative Pressure Wound Therapy and its Use in Burn Wounds: An Updated
   Systematic Review
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
DE negative pressure wound therapy; vacuum-assisted closure; burn dressing
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFT; MANAGEMENT; SUBSTITUTES
AB Negative pressure wound therapy (NPWT) is a form of wound coverage that involves negative pressure and a semi-occlusive membrane to manage wound closure. In burn care, NPWTs are currently utilized as temporary dressings for large wounds and skin-grafted burn wounds, and as a dressing on dermal substitutes. Little is known regarding optimal roles and indications of NPWT in burn care. This systematic review better characterizes the role of NPWT in burn care and provides updated recommendations. A systematic review of PubMed and Cochrane databases was performed utilizing PRISMA guidelines. All peer-reviewed publications published any time through September 17, 2021 were included. Inclusion criteria consisted of studies containing a control group without NPWT, an intervention group with NPWT, and studies involving the use of NPTW in burn care. A total of 15 studies were analyzed, with a risk of bias analysis performed to rate the quality of included studies. We find NPWT is superior to conventional dressings as a modality for skin grafting coverage, dressing on dermal substitutes, dressing on donor site wounds, and dressing on moderate to large burns. Outcomes such as length of hospitalization, length of wound healing, and rates of infections were improved in those treated with NPWT compared to conventional dressings. In conclusion, several clear benefits to utilizing NPWT have been defined for several modalities in burn care. However, further research with more robust controlled clinical trials is necessary to better quantify the role of NPWT in burn care and to better define parameters to optimize wound healing.
C1 [Kuromaru, Yuki; Choe, Deborah] Keck Sch Med, Los Angeles, CA 90033 USA.
   [Won, Paul] Univ Texas Houston, Div Plast Surg, Houston, TX 77030 USA.
   [Madrigal, Paloma] Riverside Community Hosp, Riverside, CA 92501 USA.
   [Gillenwater, T. Justin] Univ Southern Calif, Div Plast & Reconstruct Surg, Los Angeles, CA 90033 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Southern California
RP Kuromaru, Y (通讯作者)，Keck Sch Med, Los Angeles, CA 90033 USA.
EM kuromaru@usc.edu
OI Kuromaru, Yuki/0009-0006-2103-6776; Choe, Deborah/0000-0002-9081-6606;
   Maigal, Paloma/0000-0002-2646-1708; Gillenwater,
   Justin/0000-0001-9410-6030
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NR 43
TC 5
Z9 5
U1 3
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAY-JUN
PY 2025
VL 46
IS 3
BP 581
EP 589
DI 10.1093/jbcr/iraf001
EA APR 2025
PG 9
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 5ZO7J
UT WOS:001456185100001
PM 39985153
DA 2026-07-24
ER
PT J
AU Kokodziejczyk, J
   Czarny, J
   Królak, S
   Rutkowska, S
   Morycinski, S
   Mankowski, P
   Bartkowska-Sniatkowska, A
   Wachowiak, J
   Derwich, K
   Zajac-Spychaka, O
AF Kokodziejczyk, Julia
   Czarny, Jakub
   Krolak, Staniskaw
   Rutkowska, Sandra
   Morycinski, Sebastian
   Mankowski, Przemyskaw
   Bartkowska-Sniatkowska, Alicja
   Wachowiak, Jacek
   Derwich, Katarzyna
   Zajac-Spychaka, Olga
TI Successful Treatment of Fournier's Gangrene in Child with Relapsed Acute
   Lymphoblastic Leukemia: Case Report and Review of the Literature
SO INFECTION AND DRUG RESISTANCE
LA English
DT Review
DE Fournier's gangrene; Pseudomonas aeruginosa; multidrug resistance;
   therapy; child; acute lymphoblastic leukemia
ID VACUUM-ASSISTED CLOSURE; NEUTROPENIA; THERAPY
AB Neutropenia associated with onco-hematological treatment may contribute to high-mortality infections, especially caused by multidrug-resistant pathogens. In a 4-year-old girl treated due to early isolated central nervous system (CNS) relapse of B-cell acute lymphoblastic leukemia, skin lesions with traits of Fournier's gangrene caused by Klebsiella pneumoniae carbapenemase (KPC)producing Pseudomonas aeruginosa (PsA). The patient was treated with broad-spectrum antibiotic therapy and the wound was debrided and treated with VAC (vacuum-assisted closure) successfully. Despite further intensive anticancer treatment complicated by reactivation of PsA infection, there was no other episode of invasive infection anymore and, nowadays, the patient has been in complete remission for 13 months. The aim of this report is to mention that Fournier's gangrene is a rapid and potentially fatal infectious complication of chemotherapy in onco-hematological pediatric patients, especially if caused by MDR (multidrug-resistant) pathogens. Successful treatment of this necrotizing fasciitis saves a patient's life and allows to continue an effective anticancer therapy.
C1 [Kokodziejczyk, Julia; Czarny, Jakub] Poznan Univ Med Sci, Student Sci Soc, Szpitalna Str 27-33, PL-60572 Poznan, Poland.
   [Rutkowska, Sandra; Wachowiak, Jacek; Derwich, Katarzyna; Zajac-Spychaka, Olga] Poznan Univ Med Sci, Carol Jonschers Clin Hosp, Dept Pediat Oncol Hematol & Transplantol, Poznan, Poland.
   [Morycinski, Sebastian; Mankowski, Przemyskaw] Poznan Univ Med Sci, Carol Jonschers Clin Hosp, Dept Pediat Surg Traumatol & Urol, Poznan, Poland.
   [Bartkowska-Sniatkowska, Alicja] Poznan Univ Med Sci, Carol Jonschers Clin Hosp, Dept Pediat Anesthesiol & Intens Therapy, Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Poznan University of Medical Sciences; Poznan University of
   Medical Sciences
RP Kokodziejczyk, J (通讯作者)，Poznan Univ Med Sci, Student Sci Soc, Szpitalna Str 27-33, PL-60572 Poznan, Poland.
EM 86066@student.ump.edu.pl
OI Czarny, Jakub/0000-0003-4996-9157; Królak,
   Stanisław/0009-0006-6253-2629; Derwich, Katarzyna/0000-0001-7239-4035;
   Kołodziejczyk, Julia/0000-0002-2940-5445
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NR 30
TC 0
Z9 1
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2025
VL 18
BP 1667
EP 1673
DI 10.2147/IDR.S490240
PG 7
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA 0ZI3V
UT WOS:001459604100001
PM 40190595
OA gold
DA 2026-07-24
ER
PT J
AU Pandey, G
   Kolipaka, T
   Srinivasarao, DA
   Abraham, N
   Jain, A
   Srivastava, S
AF Pandey, Giriraj
   Kolipaka, Tejaswini
   Srinivasarao, Dadi A.
   Abraham, Noella
   Jain, Akshita
   Srivastava, Saurabh
TI Navigating the complexities of diabetic foot ulcers: From
   pathophysiology to advanced treatment strategies
SO JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
LA English
DT Review
DE Diabetes; Diabetic foot ulcer; Wound dressing; Nanofiber; Growth factors
ID HYPERBARIC-OXYGEN THERAPY; EPIDERMAL-GROWTH-FACTOR; PRESSURE WOUND
   THERAPY; PLATELET-RICH PLASMA; MATRIX METALLOPROTEINASES; DOUBLE-BLIND;
   SKIN-GRAFT; LEG ULCERS; MANAGEMENT; DRESSINGS
AB Diabetic foot ulcers (DFUs) are the most prevalent and serious complication among diabetic patients, causing substantial health and economic burden due to low rate of healing and high recurrence. Current therapies for DFUs include surgical debridement, wound dressings, pressure offloading, revascularization, hyperbaric oxygen therapy, low-level laser therapy, and negative pressure wound therapy. In this review, we discussed conventional and emerging therapies using hydrogel and nanofiber-based treatments, stem cell approaches, 3D bioprinting, growth factors, matrix metalloproteinase (MMP) modulators, and bioengineered skin substitutes, which showed improved healing and reduced the risk of amputation. The current article attempts to give an in-depth overview of DFU management by examining established and innovative techniques. Further, this review emphasizes the necessity of multidisciplinary approaches to enhance patient compliance and lessen the burden of devastating pathological conditions.
C1 [Pandey, Giriraj; Kolipaka, Tejaswini; Srinivasarao, Dadi A.; Abraham, Noella; Jain, Akshita; Srivastava, Saurabh] Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Pharmaceut Innovat & Translat Res Lab PITRL, Hyderabad, India.
C3 National Institute of Pharmaceutical Education & Research, S.A.S. Nagar
   (Mohali); National Institute of Pharmaceutical Education & Research,
   Hyderabad
RP Srivastava, S (通讯作者)，Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Pharmaceut Innovat & Translat Res Lab PITRL, Hyderabad, India.
EM saurabh@niperhyd.ac.in
RI Srinivasarao, Dadi/K-7507-2018; Srivastava, Saurabh/GWD-0786-2022
OI Srivastava, Saurabh/0000-0003-0723-4363
FU Department of Pharmaceuticals (DoP) , Ministry of Chemicals and
   Fertilizers, Govt. of India
FX The authors would like to acknowledge the research funding support by
   the Department of Pharmaceuticals (DoP) , Ministry of Chemicals and
   Fertilizers, Govt. of India to "Pharmaceutical Innovation and
   Translational Research Lab" (PITRL) , Department of Pharmaceutics,
   National Institute of Pharmaceutical Education and Research (NIPER)
   Hyderabad, INDIA.
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NR 263
TC 12
Z9 12
U1 10
U2 32
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1773-2247
EI 2588-8943
J9 J DRUG DELIV SCI TEC
JI J. Drug Deliv. Sci. Technol.
PD MAY
PY 2025
VL 107
AR 106852
DI 10.1016/j.jddst.2025.106852
EA MAR 2025
PG 30
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0ZW2S
UT WOS:001459966300001
DA 2026-07-24
ER
PT J
AU Li, TH
   Lin, CH
   Peng, CK
   Wu, YC
   Hsieh, TC
   Lee, CH
   Liu, YC
   Huang, KL
   Tam, KW
   Chang, SC
AF Li, Tse-Hsi
   Lin, Cheng-Hsin
   Peng, Chung-Kan
   Wu, Yi-Chun
   Hsieh, Tsung-Cheng
   Lee, Chi-Hung
   Liu, Yung-Ching
   Huang, Kun-Lun
   Tam, Ka-Wai
   Chang, Shun-Cheng
TI Effects of adjuvant hyperbaric oxygen therapy and real-time fluorescent
   imaging on deep sternal wound infection: a retrospective study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE bioburden detection; deep sternal wound infection; fluorescent imaging;
   hyperbaric oxygen therapy; negative pressure wound therapy; pressure
   wound therapy; osteomyelitis; wound; wound care; wound dressing; wound
   healing
ID VACUUM-ASSISTED CLOSURE; PRESSURE SUCTION DRAINAGE; LONG-TERM SURVIVAL;
   NEGATIVE-PRESSURE; CLOSED DRAINAGE; RISK-FACTORS; MANAGEMENT;
   MEDIASTINITIS; STERNOTOMY; OSTEOMYELITIS
AB Objective: Deep sternal wound infection (DSWI) is a rare but devastating complication that is estimated to occur in 1-2% of patients after median sternotomy. Current standard of care (SoC) comprises antibiotics, debridement and negative pressure wound therapy (NPWT). Hyperbaric oxygen therapy (HBOT) appears to be an effective adjuvant therapy for osteomyelitis. The aim of this study was to determine the effectiveness of HBOT and real-time fluorescence imaging (RTFI) in a DSWI treatment protocol and their benefits on infection control. Method: A retrospective analysis of DSWI management was performed. Enrolled patients were divided into two groups: HBOT group and RTFI group. Patients in the HBOT group received SoC, HBOT, NPWT and reconstructive flap surgery. Patients in the RTFI group received the same therapeutic plan as well as treatment with a RTFI device (MolecuLight i:X (MolecuLight, Inc., Canada) to achieve high-quality debridement. Infection status and short-term outcomes within three months were measured. Long-term outcomes were analysed at a 12-month follow-up. Results: Of the 55 patients enrolled: 22 in the HBOT group and 33 in the RTFI group. Infection control status, evaluated in terms of white blood cell counts and C-reactive protein levels, antibiotic use duration, antibiotic costs, reinfection rate and osteomyelitis recurrence rate, were statistically significantly improved in the RTFI group (<0.001, <0.001, 0.042, 0.022, 0.049 and 0.022, respectively). Length of total intensive care unit stay and duration of complete healing were statistically significantly decreased in the RTFI group (<0.001 and 0.046, respectively). Conclusion: Patients with DSWI can benefit from HBOT, especially in terms of in-hospital mortality. RTFI can be used to eliminate bacterial burden and achieve high-quality debridement, which considerably improves infection control and clinical outcomes. Declaration of interest: The authors have no conflicts of interest.
C1 [Li, Tse-Hsi] Lotung Poh Ai Hosp, Lo Hsu Med Fdn, Yilan, Taiwan.
   [Lin, Cheng-Hsin] Taipei Med Univ, Dept Surg, Sch Med, Coll Med, Taipei 110, Taiwan.
   [Peng, Chung-Kan] Triserv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Div Pulm & Crit Care Med, Taipei, Taiwan.
   [Wu, Yi-Chun; Chang, Shun-Cheng] Shuang Ho Hosp, Integrated Burn & Wound Care Ctr, Dept Surg, Div Plast Surg, New Taipei City, Taiwan.
   [Wu, Yi-Chun] Natl Yang Ming Chiao Tung Univ, Dept Biomed Engn, Taipei, Taiwan.
   [Hsieh, Tsung-Cheng] Tzu Chi Univ, Inst Med Sci, Hualien, Taiwan.
   [Lee, Chi-Hung] Taipei Med Univ, Shuang Ho Hosp, Div Infect Dis, New Taipei City, Taiwan.
   [Liu, Yung-Ching] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Infect Dis, Taipei, Taiwan.
   [Huang, Kun-Lun] Natl Def Med Ctr, Inst Aerosp & Undersea Med, Taipei, Taiwan.
   [Huang, Kun-Lun] Triserv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Taipei, Taiwan.
   [Tam, Ka-Wai] Taipei Med Univ, Shuang Ho Hosp, Dept Surg, Div Gen Surg, New Taipei City, Taiwan.
   [Tam, Ka-Wai] Taipei Med Univ, Coll Med, Sch Med, Dept Surg,Div Gen Surg, Taipei, Taiwan.
   [Tam, Ka-Wai] Taipei Med Univ, Cochrane Taiwan, Taipei, Taiwan.
   [Chang, Shun-Cheng] Taipei Med Univ, Coll Med, Sch Med, Dept Surg, Taipei, Taiwan.
C3 Taipei Medical University; Tri-Service General Hospital; National
   Defense Medical University; Taipei Medical University; National Yang
   Ming Chiao Tung University; Tzu Chi University; Taipei Medical
   University; Taipei Medical University; Shuang Ho Hospital; National
   Defense Medical University; National Defense Medical University;
   Tri-Service General Hospital; Taipei Medical University; Taipei Medical
   University; Taipei Medical University; Taipei Medical University
RP Chang, SC (通讯作者)，Shuang Ho Hosp, Integrated Burn & Wound Care Ctr, Dept Surg, Div Plast Surg, New Taipei City, Taiwan.; Chang, SC (通讯作者)，Taipei Med Univ, Coll Med, Sch Med, Dept Surg, Taipei, Taiwan.
EM csc901515@gmail.com
RI Wu, Yi-Chun/F-7934-2012; Peng, Chung-Kan/AAY-2965-2021
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NR 51
TC 3
Z9 3
U1 1
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2025
VL 34
IS 1
BP 48
EP 58
DI 10.12968/jowc.2022.0095
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1CJ3J
UT WOS:001461667900007
PM 39797755
DA 2026-07-24
ER
PT J
AU Elbanna, OH
   Eldine, AS
   Sayed, AM
   Mousa, AK
AF Elbanna, O. H.
   Eldine, A. Salah
   Sayed, A. M.
   Mousa, A. K.
TI The efficacy and safety of different negative-pressure wound therapy
   gradients on flaps outcomes
SO UPDATES IN SURGERY
LA English
DT Article
DE Flaps; Negative pressure wound therapy; Reconstructive surgery;
   Vacuum-assisted closure; Negative pressure gradients
ID VACUUM-ASSISTED CLOSURE
AB Negative pressure wound therapy (NPWT) has been shown to be beneficial for improving the wound healing process and reducing flap complications. However, the ideal NPWT settings, especially the pressure levels and application modes, are still debatable. This study examines the efficacy and safety of NPWT at different pressure gradients, namely, high (HNPWT) and low (LNPWT), to determine the optimal conditions for improving flap outcomes and minimizing complications. Over a 30-month period, 65 patients who underwent flap reconstruction were randomly assigned to three groups: HNPWT (75-125 mmHg, continuous mode), LNPWT (50-75 mmHg, intermittent mode), and conventional wound dressing (CWD). Patients were evaluated prospectively for post-operative complications, flap viability, infection, edema, and wound dehiscence. Complications were more common in the CWD group than in the HNPWT group, while the HNPWT group had the highest incidence of flap ischemia (41%). NPWT significantly reduced post-operative edema (P = 0.003) and lower infection and dehiscence rates than the CWD group (P = 0.015 and P = 0.029, respectively). Compared with HNPWT, LNPWT showed superior safety and efficacy, with fewer ischemic events, lower pain scores, faster wound healing times, and better esthetic and function outcomes. Although NPWT offers benefits over conventional wound dressing in flap reconstructions, pressure settings should be carefully adjusted. LNPWT is safer and has more satisfactory outcomes than HNPWT, with reduced ischemia and better overall healing. These findings suggest that LNPWT in the intermittent mode is most favorable for improving flap viability and minimizing adverse effects.Registration identification number NCT06080958- July 22, 2024. "Retrospectively registered" URL for the registry: http://www.clinicaltrials.gov/
C1 [Elbanna, O. H.] Aswan Univ Hosp, Aswan Fac Med, Dept Plast & Reconstruct Surg, Kasr Elhagar St,P Box 81513, Aswan 81513, Egypt.
   [Eldine, A. Salah; Mousa, A. K.] Aswan Univ Hosp, Aswan Fac Med, Dept Plast & Reconstruct Surg, Aswan, Egypt.
   [Sayed, A. M.] Ain Shams Fac Med, Dept Plast & Reconstruct Surg, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Aswan University; Egyptian Knowledge Bank
   (EKB); Aswan University; Egyptian Knowledge Bank (EKB); Ain Shams
   University
RP Elbanna, OH (通讯作者)，Aswan Univ Hosp, Aswan Fac Med, Dept Plast & Reconstruct Surg, Kasr Elhagar St,P Box 81513, Aswan 81513, Egypt.
EM osamaelbanna@aswu.edu.eg
OI Mousa, Ahmed Abdelrahim Kenawy/0000-0002-2872-361X; MOUHAMED,
   OSAMA/0000-0002-6835-525X
FU Science, Technology & Innovation Funding Authority (STDF); Egyptian
   Knowledge Bank (EKB)
FX Open access funding provided by The Science, Technology & Innovation
   Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank
   (EKB).
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NR 25
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD DEC
PY 2025
VL 77
IS 8
BP 2643
EP 2651
DI 10.1007/s13304-025-02156-7
EA MAR 2025
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9YQ9M
UT WOS:001467655100001
PM 40123035
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Shirakawa, C
   Sakamoto, Y
   Ueki, S
   Shomura, H
   Kazui, K
   Taketomi, A
AF Shirakawa, Chisato
   Sakamoto, Yuzuru
   Ueki, Shinya
   Shomura, Hiroki
   Kazui, Keizo
   Taketomi, Akinobu
TI Usefulness of a negative pressure wound therapy system for stoma closure
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hospital stay; negative pressure wound therapy; PICO; postoperative
   pain; purse-string closure; stoma; surgical site infection; wound; wound
   care; wound dressing; wound healing
ID ILEOSTOMY
AB Objective: Although wound infection rates after stoma closure have decreased, they remain high. Negative pressure wound therapy (NPWT) for stoma closure wounds can shorten healing time for many wound types. The PICO (Smith+Nephew, UK) wound dressing, a single-use NPWT system that can be used for outpatients, was introduced at the Japan Community Health Care Organization Hokkaido Hospital, Japan in November 2017. We evaluated the effectiveness of this dressing in stoma closure wounds. Method: We retrospectively evaluated patients who underwent stoma closure between March 2012 and July 2021. We compared postoperative short-term outcomes (surgical site infection (SSI), number of pain medications, and postoperative hospital stay) by allocating the patients to one of two groups: purse-string closure or purse-string closure with PICO. The purse-string closure group (PC) underwent purse-string closure alone, while the other group underwent purse-string closure and PICO (PCP). Results: A total of 35 patients were evaluated; 20 in the PC group and 15 in the PCP group. No significant differences in characteristics were noted between the groups. Comparisons between stoma closure techniques revealed that the PCP group had shorter hospital stays (p=0.04), lower SSI rates (p=0.04), and less pain medication (p<0.01) than the PC group. Comparisons between SSI occurrence revealed that the group of patients with an SSI had a higher number of colostomies compared with ileostomies (37.5% versus 0%, p<0.01, respectively), used more pain medication (p<0.01), and had longer hospital stays (p=0.04) than patients who did not have an SSI. Conclusion: After stoma closure, combining PICO with purse-string closure may be effective in preventing SSI and controlling postoperative pain. Declaration of interest: The authors have no conflicts of interest.
C1 [Shirakawa, Chisato; Sakamoto, Yuzuru; Ueki, Shinya; Shomura, Hiroki; Kazui, Keizo] Japan Community Hlth Care Org Hokkaido Hosp 8, Dept Gastroenterol Surg, 8-3-18 Nakanoshima 1 Jo,Toyohira Ku, Sapporo 0628618, Japan.
   [Sakamoto, Yuzuru] Wakkanai City Hosp 4, Dept Gastroenterol Surg, 4-11-6 Chuo, Wakkanai 0978555, Japan.
   [Taketomi, Akinobu] Hokkaido Univ, Fac Med, Grad Sch Med, Dept Gastroenterol Surg, Kita-15 Nishi-7,Kita Ku, Sapporo 0608638, Japan.
C3 Hokkaido University
RP Sakamoto, Y (通讯作者)，Japan Community Hlth Care Org Hokkaido Hosp 8, Dept Gastroenterol Surg, 8-3-18 Nakanoshima 1 Jo,Toyohira Ku, Sapporo 0628618, Japan.; Sakamoto, Y (通讯作者)，Wakkanai City Hosp 4, Dept Gastroenterol Surg, 4-11-6 Chuo, Wakkanai 0978555, Japan.
EM yuzurusakamoto18@gmail.com
CR Alvandipour M, 2016, ANN COLOPROCTOL, V32, P144, DOI 10.3393/ac.2016.32.4.144
   Amamo K, 2019, SURG TODAY, V49, P231, DOI 10.1007/s00595-018-1729-5
   Askarpour S, 2022, ABCD-ARQ BRAS CIR DI, V35, DOI 10.1590/0102-672020220002e1709
   Bertelsen CA, 2014, WORLD J SURG, V38, P774, DOI 10.1007/s00268-013-2360-7
   Bueno-Lledó J, 2021, ANN SURG, V273, P1081, DOI 10.1097/SLA.0000000000004310
   Carrano FM, 2021, BJS OPEN, V5, DOI 10.1093/bjsopen/zrab116
   Cong ZJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075519
   Curchod P, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-11856-8
   Ferrando PM, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001732
   Glass GE, 2014, BJS-BRIT J SURG, V101, P1627, DOI 10.1002/bjs.9636
   Hajibandeh S, 2018, INT J COLORECTAL DIS, V33, P1319, DOI 10.1007/s00384-018-3139-y
   Kojima K, 2021, BMC SURG, V21, DOI 10.1186/s12893-021-01446-2
   Lee JT, 2014, DIS COLON RECTUM, V57, P1282, DOI 10.1097/DCR.0000000000000209
   Matthiessen P, 2007, ANN SURG, V246, P207, DOI 10.1097/SLA.0b013e3180603024
   Mujagic E, 2018, WORLD J SURG, V42, P3888, DOI 10.1007/s00268-018-4733-4
   O'Leary DP, 2017, TECH COLOPROCTOL, V21, P863, DOI 10.1007/s10151-017-1713-x
   Obeid N, 2021, INT J COLORECTAL DIS, V36, P161, DOI 10.1007/s00384-020-03749-x
   Shah AP, 2020, J HOSP INFECT, V104, P332, DOI 10.1016/j.jhin.2019.11.006
   Wierdak M, 2021, TECH COLOPROCTOL, V25, P185, DOI 10.1007/s10151-020-02372-w
   Yane Y, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-05016-1
NR 20
TC 2
Z9 2
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2025
VL 34
IS 2
BP 106
EP 110
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1PF7G
UT WOS:001470389200002
PM 39928473
DA 2026-07-24
ER
PT J
AU Brewer, CF
   Manan, Z
   Miranda, BH
AF Brewer, Christopher F.
   Manan, Zaki
   Miranda, Benjamin H.
TI Incisional negative pressure wound therapy following abdominoplasty and
   abdominal free flap surgery: a meta-analysis of outcomes and review of
   costs
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE abdominoplasty; abdominal free flap; complications; cost; dehiscence;
   incisional negative pressure wound therapy; negative pressure; surgical
   site wound complications; wound; wound care; wound dressing; wound
   healing
ID SURGICAL SITE INFECTION; DONOR-SITE; BREAST RECONSTRUCTION; RISK;
   COMPLICATIONS; DEHISCENCE; EFFICACY
AB Objective: Incisional negative pressure wound therapy (iNPWT) is purported to enhance wound healing and reduce the incidence of surgical site wound complications (SSWCs). This systematic review and meta-analysis aimed to evaluate the efficacy and associated costs of iNPWT for abdominoplasty or abdominal free flap donor site surgeries. Method: A literature review was undertaken for studies relating to iNPWT and SSWCs following abdominoplasty or abdominal free flap procedures. Results: After applying the exclusion criteria, 12 studies were identified, incorporating 517 and 589 patients in the iNPWT and control groups, respectively. Pooled analysis identified a significant reduction in the incidence of wound dehiscence in the iNPWT group compared with the control arm (11.7% versus 20.2%, respectively; p<0.05), with meta-analysis demonstrating a relative risk (RR) of 0.60 in the iNPWT group versus controls (RR: 0.60, 95% confidence interval: 0.42-0.87, I2=0%; p=0.85). Incidence of all other SSWCs was comparable between both groups. The two studies which reported associated healthcare costs found iNPWT to be comparable with standard of care. Conclusion: This systematic review and meta-analysis provides evidence to support the judicious use of iNPWT to reduce wound dehiscence in high-risk abdominoplasty and abdominal free flap donor site surgeries. The evidence for reduction of other SSWCs is lacking, and any effect is likely to be minimal. Heterogeneity and poor study design limit the strength of these quantitative findings, and higher quality randomised controlled trials are required in this area.
C1 [Brewer, Christopher F.] Addenbrookes Hosp, Dept Plast Surg, Cambridge, England.
   [Manan, Zaki; Miranda, Benjamin H.] St Andrews Ctr Plast Surg & Burns, St Andrews Anglia Ruskin StAAR Res Grp, Cambridge, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital
RP Miranda, BH (通讯作者)，St Andrews Ctr Plast Surg & Burns, St Andrews Anglia Ruskin StAAR Res Grp, Cambridge, England.
EM ben.miranda@nhs.net
RI /AAV-3434-2020; Brewer, Christopher/NZO-1408-2025
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
   Abesamis GM, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002141
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   Bowden J, 2015, INT J EPIDEMIOL, V44, P512, DOI 10.1093/ije/dyv080
   Chicco M, 2021, ANN PLAS SURG, V87, P478, DOI 10.1097/SAP.0000000000002722
   Cochrane Training, Review Manager (RevMan)
   de Lissovoy G, 2009, AM J INFECT CONTROL, V37, P387, DOI 10.1016/j.ajic.2008.12.010
   Doval AF, 2021, WOUNDS, V33, P81
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   jamovi, Stats made simple
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   Limpiado M, 2022, ANN PLAS SURG, V89, P529, DOI 10.1097/SAP.0000000000003285
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   Wang J, 2021, J CLIN MED, V10, DOI 10.3390/jcm10215176
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
   Wells GA., 2020, NEWCASTLE OTTAWA SCA
   Wong M, 2020, Incisional negative pressure wound therapy in high risk patients undergoing panniculectomy: a prospective randomized controlled trial
   Xie WW, 2022, INT WOUND J, V19, P1319, DOI 10.1111/iwj.13726
   Yu LL, 2018, AM J OBSTET GYNECOL, V218, P200, DOI 10.1016/j.ajog.2017.09.017
NR 34
TC 1
Z9 1
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2025
VL 34
IS 4
BP 286
EP 293
DI 10.12968/jowc.2023.0113
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1SQ3W
UT WOS:001472700300005
PM 40227922
DA 2026-07-24
ER
PT J
AU Yao, XF
   Wang, YJ
   Lin, YS
AF Yao, Xiao-Feng
   Wang, Yen-Jen
   Lin, Yang-Sheng
TI Palliative care with negative pressure wound therapy application in
   malignant wounds: a systematic review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE malignancy; malignant wound; negative pressure wound therapy; palliative
   care; quality of life; wound; wound care; wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; COMPLICATIONS; RESECTION; BIOFILMS;
   QUALITY
AB Objective: To synthesise and appraise the evidence for and benefits of palliative application of negative pressure wound therapy (NPWT) in malignant wounds. Method: We performed a systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). MEDLINE, Embase, Cochrane Library and trial registers (www.clinicaltrials.gov) from inception to 1 June 2021 were searched. Quality was assessed using the tool of methodological quality and synthesis from the 2018 BMJ Evidence-Based Medicine article on case series and case report synthesis. Results: Of 765 articles screened, 14 eligible studies were included in the review. All were case reports and included a total of 22 patients. The mean age of the patients was 60.7 (range: 33-77) years. The location of the hard-to-heal wounds was widely distributed: five wounds on the scalp; three wounds over the anogenital area; and the remaining wounds on the trunk and extremities. The reported outcomes included: improvement of wound healing; decreased exudation and malodour of the wound; decreased pain sensation; eligibility for further treatment; and a shift to the homecare system. Conclusion: The findings of this study suggested NPWT could be a choice in palliative care for patients with malignant wounds. However, more studies are needed to evaluate the efficacy of NPWT in these wounds. Declaration of interest: The authors have no conflicts of interest to declare. The authors declare amendments to the protocol (PROSPERO number CRD42020214516), which included performing an additional search three months prior to submission.
C1 [Yao, Xiao-Feng; Wang, Yen-Jen] MacKay Mem Hosp, Dept Dermatol, Taipei, Taiwan.
   [Wang, Yen-Jen] MacKay Jr Coll Med Nursing & Management, Dept Cosmet Applicat & Management, Taipei, Taiwan.
   [Lin, Yang-Sheng] MacKay Med Coll, Dept Med, New Taipei City, Taiwan.
   [Lin, Yang-Sheng] Mackay Mem Hosp, Dept Internal Med, Div Gastroenterol, Taipei, Taiwan.
   [Lin, Yang-Sheng] MacKay Mem Hosp, Evidence Based Med Ctr, Taipei, Taiwan.
   [Lin, Yang-Sheng] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan.
C3 Mackay Memorial Hospital; Mackay Junior College of Medicine, Nursing &
   Management; Mackay Medical University; Mackay Memorial Hospital; Mackay
   Memorial Hospital; Taipei Medical University
RP Lin, YS (通讯作者)，MacKay Med Coll, Dept Med, New Taipei City, Taiwan.; Lin, YS (通讯作者)，Mackay Mem Hosp, Dept Internal Med, Div Gastroenterol, Taipei, Taiwan.; Lin, YS (通讯作者)，MacKay Mem Hosp, Evidence Based Med Ctr, Taipei, Taiwan.; Lin, YS (通讯作者)，Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan.
EM d118107002@tmu.edu.tw
OI Wang, Yen-Jen/0000-0002-0425-9154
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NR 67
TC 0
Z9 0
U1 2
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2025
VL 34
IS 4
BP 304
EP 311
DI 10.12968/jowc.2021.0254
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1SQ3W
UT WOS:001472700300007
PM 40227927
DA 2026-07-24
ER
PT J
AU Yu, GM
   Huang, XM
   Lin, RJ
   Zheng, SW
AF Yu, Genmiao
   Huang, Xiongmei
   Lin, Rongjia
   Zheng, Shengwu
TI Efficacy and safety of negative pressure wound therapy in the treatment
   of patients with cardiovascular implantable electronic devices pocket
   infection
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Negative-pressure wound therapy; Cardiac implantable electronic devices;
   Prosthesis-related infections; CIED pocket infection
ID TRANSVENOUS LEAD EXTRACTION; VACUUM-ASSISTED CLOSURE; ASSOCIATION;
   MICROBIOLOGY; MORTALITY; PACEMAKER; TRENDS; HRS
AB ObjectivesTo evaluate the efficacy of negative-pressure wound therapy (NPWT) for cardiac implantable electronic device (CIED) pocket infection, eliminating the need for CIED and leads extraction.MethodsThe NPWT cohort consisted of 42 patients with CIED infection who were treated with NPWT from 2013 to 2023. Among them, 3 patients had a systemic infection and 1 patient had incomplete data. We performed a case-control study in which the NPWT group was compared with the conservative treatment group (40 patients). Main outcomes included failure rate (CIED/lead extraction during the 1-year follow-up, 30-day mortality/chronic infection, or infection-related mortality/recurrence) and infection-free time, with cure defined as absence of failure criteria.ResultsA total of 38 patients with pocket infections were treated with NPWT from 2013 to 2023. NPWT was curative in 78.9% (n = 30 of 38) of patients who remained free of infection [median follow-up 12.63 months, interquartile range (IQR): 12.30-34.10 months]. Compared with patients who were treated conservatively, the two groups demonstrated balanced baseline characteristics. Patients who were treated with NPWT had a significantly higher cure rate (78.9% vs. 55.0%, n = 22 of 40; p = 0.025) and a longer mean infection-free time at the 1-year follow-up (338.00 vs. 285.20 days, p = 0.034).ConclusionNPWT is an effective alternative for patients with CIED pocket infections who are unsuitable or unwilling to undergo CIED and leads extraction.Trial registrationThis study was approved by the Chinese Clinical Trial Registry (Clinicaltrials.gov number: ChiCTR2300073560) on July 07, 2023.
C1 [Yu, Genmiao; Huang, Xiongmei; Zheng, Shengwu] Fuzhou Univ, Fujian Prov Hosp, Affiliated Prov Hosp, Dept Burn & Plast Surg, Fuzhou 350000, Peoples R China.
   [Yu, Genmiao; Huang, Xiongmei; Zheng, Shengwu] Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350000, Peoples R China.
   [Lin, Rongjia] Fuzhou Univ, Fujian Prov Hosp, Affiliated Prov Hosp, Dept Thorac Surg, Fuzhou 350000, Peoples R China.
C3 Fuzhou University; Fujian Provincial Hospital; Fujian Medical
   University; Fuzhou University; Fujian Provincial Hospital
RP Zheng, SW (通讯作者)，Fuzhou Univ, Fujian Prov Hosp, Affiliated Prov Hosp, Dept Burn & Plast Surg, Fuzhou 350000, Peoples R China.; Zheng, SW (通讯作者)，Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350000, Peoples R China.
EM zhengshengwu_fjsl@126.com
RI Lin, Rongjia/NJS-2890-2025
OI Lin, Rongjia/0000-0002-8675-1387
CR Al-Bataineh M, 2010, J INTERV CARD ELECTR, V27, P137, DOI 10.1007/s10840-009-9444-1
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NR 41
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD APR 23
PY 2025
VL 25
IS 1
AR 305
DI 10.1186/s12872-025-04769-7
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1UI3I
UT WOS:001473845800001
PM 40269780
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU De Pellegrin, L
   Zucal, I
   Treglia, G
   Parodi, C
   Schweizer, R
   De Monti, M
   Harder, Y
AF De Pellegrin, Laura
   Zucal, Isabel
   Treglia, Giorgio
   Parodi, Corrado
   Schweizer, Riccardo
   De Monti, Marco
   Harder, Yves
TI Salvage of the Mastectomy Pocket in Infected Implant-Based Breast
   Reconstruction Using Negative-Pressure Wound Therapy with Instillation
   and Dwell: A Systematic Review and Meta-Analysis
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE negative-pressure wound therapy; NPWTi-d; breast reconstruction; breast
   implant; periprosthetic breast infection
ID CAPSULAR CONTRACTURE; MANAGEMENT; RATES
AB Background: Breast cancer, irrespective of gender, stands as the most prevalent cancer globally, with an annual estimate of 2.3 million new cases. Surgical intervention, including therapeutic mastectomy (excluding prophylactic procedures), is performed on approximately 28% of patients, necessitating subsequent breast reconstruction. Although implant-based breast reconstruction (IBBR) is frequently employed due to its relative ease compared to autologous methods, it presents a notable risk for complications at mid-term such as peri-prosthetic infections. These complications can lead to implant loss and the eventual compromise of the mastectomy pocket. To address these complications, negative pressure wound therapy with instillation and dwell (NPWTi-d) emerges as a promising rescue intervention, known for its capacity to significantly reduce bacterial load and potentially salvage compromised soft tissues. However, the evidence supporting its effectiveness in infected pockets after mastectomy is currently insufficient. This study aims at investigating the efficacy of NPWTi-d in the management of peri-prosthetic mastectomy pocket infection. Methods: A thorough literature search has been concluded through PubMed, Web of Science, and Cochrane databases up until 18th March 2025 on evaluating NPWTi-d's ability to manage peri-prosthetic infections and preserve mastectomy pockets for subsequent reconstruction. Furthermore, a meta-analysis on the salvage rate of the mastectomy pocket was carried out, while for other outcomes, a descriptive analysis was applied. Results: Nine studies (n = 230 patients) were included, investigating whether the us NPWTi-d was successful in treating peri-prosthetic infection and preserving the mastectomy pocket for subsequent reconstruction by expander or implant. The pooled salvage rate of the implant-based BR due to the use of NPWTi-d was 86.1% (95%CI: 80.6-91.6%). Preservation of the skin envelope avoided secondary reconstruction after a defined time interval, reducing number and complexity of surgeries and related costs. Conclusions: This innovative surgical approach should be considered in selected cases of infected implants after breast reconstruction in breast cancer centers. However, the actual low level of evidence is based on case series, and it is not possible to define generally accepted recommendations for the use of NPWTi-d to save the mastectomy pocket.
C1 [De Pellegrin, Laura; Zucal, Isabel; Parodi, Corrado; Schweizer, Riccardo; De Monti, Marco] Ente Osped Cantonale EOC, Osped Reg Lugano, Dept Plast Reconstruct & Aesthet Surg EOC, CH-6900 Lugano, Switzerland.
   [Treglia, Giorgio] Univ Svizzera Italiana, Fac Biomed Sci, CH-6900 Lugano, Switzerland.
   [Treglia, Giorgio] Ente Osped Cantonale EOC, Div Med Educ & Res, CH-6500 Bellinzona, Switzerland.
   [Schweizer, Riccardo] Luzerner Kantonsspital, Dept Hand Surg & Plast Surg, CH-6000 Luzern, Switzerland.
   [De Monti, Marco] Ente Osped Cantonale EOC, Osped Reg Mendrisio, Dept Gen Surg, CH-6850 Mendrisio, Switzerland.
   [Harder, Yves] Univ Hosp Lausanne CHUV, Dept Plast Reconstruct & Aesthet Surg & Hand Surg, CH-1011 Lausanne, Switzerland.
   [Harder, Yves] Univ Lausanne UNIL, Fac Biol & Med, CH-1015 Lausanne, Switzerland.
C3 Universita della Svizzera Italiana; Lucerne Cantonal Hospital;
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne
RP Harder, Y (通讯作者)，Univ Hosp Lausanne CHUV, Dept Plast Reconstruct & Aesthet Surg & Hand Surg, CH-1011 Lausanne, Switzerland.; Harder, Y (通讯作者)，Univ Lausanne UNIL, Fac Biol & Med, CH-1015 Lausanne, Switzerland.
EM laura.depellegrin@gmx.de; isabel.zucal@eoc.ch; giorgio.treglia@eoc.ch;
   corrado.parodi@eoc.ch; marco.demonti@eoc.ch; yves.harder@chuv.ch
RI ; Treglia, Giorgio/I-2727-2013; De Monti, Marco/HJI-5543-2023; Zucal,
   Isabel/IZD-4908-2023
OI Harder, Yves/0000-0002-2557-249X; Treglia, Giorgio/0000-0001-9808-780X;
   De Monti, Marco/0000-0003-0927-3438; Schweizer,
   Riccardo/0000-0002-5686-8496; De Pellegrin, Laura Silvia
   Caterina/0009-0004-6010-7886
CR Accurso A, 2017, AESTHET PLAST SURG, V41, P36, DOI 10.1007/s00266-016-0739-1
   Ahmed S, 2024, PRS-GLOB OPEN, V12, DOI 10.1097/GOX.0000000000006116
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   Paepke S, 2009, ANN SURG, V250, P288, DOI 10.1097/SLA.0b013e3181b0c7d8
   prisma statement, About us
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NR 36
TC 2
Z9 2
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR 16
PY 2025
VL 14
IS 8
AR 2730
DI 10.3390/jcm14082730
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1WY6T
UT WOS:001475624900001
PM 40283560
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Chariker, ME
   Handsaker, J
   McCarthy, C
AF Chariker, Mark E.
   Handsaker, Joanne
   McCarthy, Catherine
TI Removing the Complexities Associated with Traditional Negative Pressure
   Wound Therapy (tNPWT) Bridging Applications
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE bridging technique; hard port; negative pressure wound therapy; soft
   port
ID VACUUM-ASSISTED CLOSURE
AB Background. Negative pressure wound therapy (NPWT) is an effective intervention for challenging wounds across multiple indications. Its application sometimes requires a technique known as 'bridging" to prevent ulcerations caused by delivery port and tubing when positioning the device, which requires extra time and resources. The bridging technique may be adopted when it is considered essential to move the NPWT delivery port away from the wound bed or when treating wounds in close proximity to each other. Materials and Methods. A survey was undertaken by 200 health care professionals (HCPs) in the United States who are experienced in utilizing traditional negative pressure wound therapy (tNPWT) and bridging. Primary objectives were to explore HCP opinion on 2 types of tNPWT delivery ports (soft and hard) between 2 leading manufacturers. Questions focused on the need for bridging, alleviation of complexity in application, and reducing concerns relating to medical device-related pressure injury when applied to awkward anatomical areas. Results. HCPs (75%; n=150) largely agreed that the bridging technique makes application of tNPWT slightly more challenging. Reasons included additional time taken to apply (74%; n=148), increased dressing resource (67%; n=13 4), and additional staff required (50%; n=100). Over half (53%; n=106) agreed that the soft port can eliminate the need for bridging. The majority of wound specialists were significantly less likely to favor a hard port (58%; n=116). Two further potential benefits of using a tNPWT soft port include the associated risk of pain/pressure when applying a hard port over a smaller wound size (29%; n=58) and certain anatomical areas which pose a risk of pressure injury or kinked/twisted tubing (31%; n=62). Conclusion. tNPWT soft ports remain effective regardless of kinks or twists and can eliminate bridging in anatomical areas where patients may weight-bear on tubing or delivery ports, saving time and decreasing risks of periwound trauma.
C1 [Chariker, Mark E.] Norton Childrens Hosp, Dept Craniofacial & Pediat Plast Surg, Louisville, KY USA.
   [Handsaker, Joanne; McCarthy, Catherine] Smith & Nephew, Global Clin Strategy Adv Wound Management, Watford, England.
RP McCarthy, C (通讯作者)，Smith & Nephew, Watford WD18 8YE, England.
EM catherine.mccarthy@smith-nephew.com
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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   Brownhill VR, 2021, ADV WOUND CARE, V10, P345, DOI 10.1089/wound.2020.1218
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   Choi WW, 2011, PEDIATR SURG INT, V27, P907, DOI 10.1007/s00383-011-2868-6
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   The Joint Commission Division of Healthcare Improvement, 2018, QUICK SAFETY, V43, P1
NR 25
TC 0
Z9 0
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2025
VL 37
IS 3
BP 107
EP 113
DI 10.25270/wnds/24074
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 1YJ9N
UT WOS:001476594100002
PM 40215360
DA 2026-07-24
ER
PT J
AU Lindsay, R
   McCarthy, CH
   Lin, JR
   Nherera, L
   Murdoch, JM
AF Lindsay, Rodney
   McCarthy, Catherine H.
   Lin, Jiunn-Ru (Angela)
   Nherera, Leo
   Murdoch, Julie M.
TI From Traditional to Single Use: The Evolution of Negative Pressure Wound
   Therapy as a Mechanism for Optimal Wound Management
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE traditional negative pressure wound therapy; device; single-use negative
   pressure wound; therapy device; acute wounds; chronic wounds; wound
   clinics
ID CONSENSUS PANEL RECOMMENDATIONS
AB Background. The safety and efficacy of negative pressure wound therapy (NPWT) is well established. The technology has evolved to include 2 device categories: traditional NPWT (tNPWT) and single-use NPWT (sNPWT). Each mode has unique properties benefitting multiple aspects of wound care. Objective. To assess the proportion of tNPWT-treated wounds that could be amenable to sNPWT, thus determining optimal therapy. Materials and Methods. A de-identified dataset of wounds managed with tNPWT in outpatient clinics in the United States from 2006 through 2020 was analyzed to determine the proportion of wounds that could have been managed with sNPWT based on wound area, depth, and exudate volume, as well as sNPWT dressing size. Descriptive statistics were reported. Results. A total of 5040 wounds were analyzed. Ten wound types were identified, the most prevalent being surgical open wound (n = 2268 [45%]). All 8 commercially available sNPWT device dressing sizes, from 1 manufacturer, were included in the analysis. Overall, 3403 wounds (68%) would have been suitable to receive sNPWT instead of tNPWT at treatment commencement. Conclusion. The utilization of tNPWT is ideally positioned for large, deep, highly exuding wounds. However, by assessing a wound's dimensions and exudate volume and type, a more appropriate NPWT device selection can be made; thus, ensuring the delivery of therapy with the most suitable device modality appropriate for the wound and patient while also maximizing resources.
C1 [Lindsay, Rodney] Carrollton Reg Med Ctr, Comprehens Wound Ctr, Carrollton, TX USA.
   [McCarthy, Catherine H.; Murdoch, Julie M.] Smith & Nephew, Global Clin & Med Affairs, Bldg 5,Hatters Lane,Croxley Pk, Watford WD18 8YE, England.
   [Lin, Jiunn-Ru (Angela); Nherera, Leo] Smith & Nephew, Hlth Econ & Outcomes Res Data Analyt, Ft Worth, TX USA.
C3 Smith & Nephew
RP Murdoch, JM (通讯作者)，Smith & Nephew, Global Clin & Med Affairs, Bldg 5,Hatters Lane,Croxley Pk, Watford WD18 8YE, England.
EM Julie.Murdoch@smith-nephew.com
CR Adeyemi A, 2018, WOUNDS, V30, pE13
   Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
   Brownhill VR, 2021, ADV WOUND CARE, V10, P345, DOI 10.1089/wound.2020.1218
   2024, Journal of Wound Management Official journal of the European Wound Management Association, DOI [10.35279/jowm2024.25.02.sup01, 10.35279/jowm2024.25.02.sup01, DOI 10.35279/JOWM2024.25.02.SUP01]
   Hampton Jane, 2015, Br J Community Nurs, VSuppl Community Wound Care, pS16, DOI [10.12968/bjcn.2015.20.sup6.s14, 10.12968/bjcn.2015.20.Sup6.S14]
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   Hurd T, 2021, WOUNDS, V33, pS1
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   Kirsner RS, 2020, WOUNDS, V32, P328
   Kirsner RS, 2020, WOUND MANAG PREV, V66, P30, DOI 10.25270/wmp.2020.3.3038
   Loney A, 2023, WOUNDS, V35, pE209, DOI 10.25270/wnds/22085
   Rippon MG, 2022, J WOUND CARE, V31, P648, DOI 10.12968/jowc.2022.31.8.648
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   Upton D, 2013, J WOUND CARE, V22, P582, DOI 10.12968/jowc.2013.22.11.582
NR 15
TC 1
Z9 1
U1 2
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2025
VL 37
IS 3
BP 125
EP 133
DI 10.25270/wnds/24078
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 1YJ9N
UT WOS:001476594100005
PM 40215363
DA 2026-07-24
ER
PT J
AU Stanciu, CT
   Vermesan, D
   Pop, DL
   Hogea, B
   Vlad, SV
AF Stanciu, Cristina-Teodora
   Vermesan, Dinu
   Pop, Daniel Laurentiu
   Hogea, Bogdan
   Vlad, Silviu Valentin
TI Functional and Clinical Outcomes in Acute Wound Management: Measuring
   the Impact of Negative Pressure Wound Therapy and Specialized Physical
   Therapy
SO LIFE-BASEL
LA English
DT Article
DE negative pressure wound therapy; rehabilitation techniques;
   proprioceptive neuromuscular facilitation; wound healing; joint mobility
ID VACUUM-ASSISTED CLOSURE
AB Background and Objectives: Optimizing functional recovery alongside wound healing remains a challenge in acute wound management. Negative Pressure Wound Therapy (NPWT) is widely used to promote tissue regeneration and reduce edema, yet its impact on functional outcomes and quality of life is less explored. This study evaluates the effects of NPWT alone versus NPWT combined with physiotherapy, focusing on functional recovery and patient-reported outcomes. Materials and Methods: This prospective study included patients with acute wounds at the Timisoara County Emergency Clinical Hospital, treated between 2020 and 2024. Participants were divided into two groups: Group 1, receiving NPWT exclusively, and Group 2, undergoing NPWT combined with physiotherapy (Proprioceptive Neuro-muscular Facilitation, Kabat diagonals, manual lymphatic drainage, and proprioceptive exercises). Assessments included joint mobility (goniometry), edema (circumferential measurements), muscle strength (Manual Muscle Testing), and patient-reported outcomes using WHOQOL-BREF, SF-36, and HADS questionnaires. Results: Results demonstrated that, at 10 days, patients in the specialized physiotherapy group had significantly greater ankle dorsiflexion (18.10 +/- 1.63 degrees) compared to the classical group (10.05 +/- 1.76 degrees; p < 0.001). Knee flexion in the specialized group was 134.58 +/- 5.15 degrees versus 115.57 +/- 5.32 degrees in the classical group (p < 0.001). Edema circumference and depth were reduced in both groups, with minor but notable improvements in the specialized group at later follow-ups (p < 0.05). Self-reported quality of life (SF-36, WHOQOL-BREF) and mental health (HADS) scores were slightly better at 10 days in the specialized group, although differences diminished by 6 months. Conclusions: Combining NPWT with specialized physiotherapy techniques enhances functional recovery and quality of life in acute wound patients. These findings support the integration of multi-disciplinary rehabilitation to optimize patient outcomes.
C1 [Stanciu, Cristina-Teodora] Victor Babes Univ Med & Pharm Timisoara, Doctoral Sch, Timisoara 300041, Romania.
   [Vermesan, Dinu; Pop, Daniel Laurentiu; Hogea, Bogdan] Victor Babes Univ Med & Pharm Timisoara, Dept Orthoped Traumatol Urol & Med Imaging 16, Timisoara 300041, Romania.
   [Vlad, Silviu Valentin] Univ Oradea, Fac Med, Dept Surg, Oradea 410073, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; University of Oradea
RP Hogea, B (通讯作者)，Victor Babes Univ Med & Pharm Timisoara, Dept Orthoped Traumatol Urol & Med Imaging 16, Timisoara 300041, Romania.
EM cristina.stanciu@umft.ro; dinu@vermesan.ro;
   daniellaurentiupop@yahoo.com; hogea.bogdan@umft.ro;
   siviu.vlad@didactic.uoradea.ro
RI ; Vlad, Silviu/JWP-8448-2024
OI Hogea, Bogdan/0000-0003-4924-7832; 
FU Victor Babes University of Medicine and Pharmacy for paying the APC
FX We acknowledge Victor Babes University of Medicine and Pharmacy for
   paying the APC.
CR Altman DG, 2005, BMJ-BRIT MED J, V331, P903, DOI 10.1136/bmj.331.7521.903
   [Anonymous], 2018, International classification of diseases
   [Anonymous], 1996, WHOQOL-BREF : introduction, administration, scoring and generic version of the assessment : field trial version, December 1996
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 25
TC 1
Z9 1
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD MAR 21
PY 2025
VL 15
IS 4
AR 511
DI 10.3390/life15040511
PG 16
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 1YM0A
UT WOS:001476647400001
PM 40283066
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ak, AA
   Agrawal, V
   Dwivedi, S
   Pandey, M
   Tripathy, GN
   Taleja, H
   Anand, S
   Chandran, D
AF Anto Ak, Ajin
   Agrawal, Vivek
   Dwivedi, Surjeet
   Pandey, Mohneesh
   Tripathy, G. N.
   Taleja, Hitesh
   Anand, S.
   Chandran, Dinoy
TI Analgesic Effect and Safety of Topical Sevoflurane During
   Dressing/Debridement of Chronic Painful Ulcer: Original Article
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Sevoflurane; Analgesia; Visual analogue score; Negative pressure wound
   therapy; Split skin grafting
ID CHRONIC VENOUS ULCERS
AB Painful ulcers have shown high economic and epidemiologic impacts. This is a novel study to assess the analgesic effectiveness and safety of topical sevoflurane during the debridement of a painful ulcer. This study is a prospective observational study that includes 100 patients above the age of 20 years, with chronically infected ulcers (more than 4 weeks) associated with pain (baseline visual analog scale (VAS) score > 8) of various etiologies requiring dressing/debridement. Debridement was done with IV analgesic drugs only or both IV analgesia and topical sevoflurane on alternative dressing as a crossover design. Group 1 (odd day) underwent IV analgesic alone-Injection Paracetamol 1 g IV, and Group 2 (even day) underwent IV analgesic + topical sevoflurane-Injection Paracetamol 1 g IV + sevoflurane topically applied. Dose of sevoflurane-1 mL/1 cm(2) of ulcer area. The gauze piece was soaked with sevoflurane and kept over the ulcer for 7-10 min before starting the dressing/debridement. The patient was kept blinded, and the VAS score was recorded every time. The mean age was 66 +/- 12 years, with female patients on the higher side. The etiology includes 38% arterial ulcers, 35% venous ulcers, and the rest traumatic ulcers. There was a significant reduction in the mean VAS scores during subsequent dressings. This novel study group had a dominant of elderly patients who were suffering from chronic ulcers. Sevoflurane was found to be beneficial in managing pain in these patients. Its use in the elderly population is particularly promising due to its potential to alleviate patients suffering from chronic ulcers. This study opens up new possibilities for utilizing sevoflurane in pain management beyond its traditional use in anesthesia.
C1 [Anto Ak, Ajin; Anand, S.] Command Hosp Air Force, Dept Surg, Bangalore, India.
   [Agrawal, Vivek] Command Hosp AF, Dept Vasc Surg, Bangalore, India.
   [Dwivedi, Surjeet; Chandran, Dinoy] AFMC, Dept Surg, Pune, Maharashtra, India.
   [Pandey, Mohneesh; Tripathy, G. N.; Taleja, Hitesh] 92 Base Hosp, Dept Surg, Srinagar, India.
C3 Armed Forces Medical College
RP Ak, AA (通讯作者)，Command Hosp Air Force, Dept Surg, Bangalore, India.
EM ajinanto@gmail.com; viveksadhnaom@gmail.com; surjeetdwivedi@gmail.com;
   mohneeshpandey22@gmail.com; girijanandantripathy@gmail.com;
   hitesh5287@gmail.com; anandvijay422@gmail.com; drdinoyr@gmail.com
OI AK, Ajin Anto/0000-0001-6271-4349
CR Fernández-Ginés FD, 2020, INT WOUND J, V17, P83, DOI 10.1111/iwj.13235
   Fernández-Ginés FD, 2019, EUR J HOSP PHARM, V26, P229, DOI 10.1136/ejhpharm-2017-001421
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   Imbernón-Moya A, 2016, INT WOUND J, V13, P1060, DOI 10.1111/iwj.12474
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NR 15
TC 0
Z9 0
U1 0
U2 5
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD FEB
PY 2026
VL 88
IS 1
BP 123
EP 128
DI 10.1007/s12262-025-04358-0
EA APR 2025
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DP4HL
UT WOS:001476832500001
DA 2026-07-24
ER
PT J
AU Stanciu, CT
   Vaduva, MMB
   Pop, DL
   Vermesan, D
AF Stanciu, Cristina-Teodora
   Vaduva, Marcel Mihai Berceanu
   Pop, Daniel Laurentiu
   Vermesan, Dinu
TI Enhancing Quality of Life in Patients with Acute Wounds: The Synergistic
   Effects of Negative Pressure Wound Therapy and Physiotherapy
SO BIOMEDICINES
LA English
DT Article
DE negative pressure wound therapy; rehabilitation; quality of life; edema
   reduction; functional recovery
ID COGNITIVE REHABILITATION; SF-36
AB Background and Objectives: Negative Pressure Wound Therapy (NPWT) is widely used in acute wound management, promoting tissue regeneration and edema reduction. However, the effects of integrating physiotherapy on functional recovery and quality of life remain underexplored. This study assesses the combined impact of NPWT and physiotherapy on functional and clinical outcomes in patients with acute wounds at the Timisoara County Emergency Clinical Hospital. Methods: This cross-sectional study included 205 patients divided into two groups: NPWT-only (n = 110) and NPWT plus physiotherapy (n = 95). Clinical and functional parameters, including joint mobility, edema, and pain, were assessed at baseline, ten days, six weeks, and six months. Quality of life and mental health were evaluated using WHOQOL-BREF, SF-36, VAS, and HADS questionnaires. Results: Compared to NPWT alone, the NPWT + physiotherapy group showed at discharge greater edema reduction (40.58 +/- 2.48 vs. 41.15 +/- 2.39), improved joint mobility (14.22 +/- 1.66 degrees vs. 10.05 +/- 1.76 degrees, p < 0.05), and a more significant pain decrease (VAS reduction to 5.68 +/- 1.13 vs. 6.7 +/- 1.05, p < 0.001). Quality of life scores improved notably, with higher WHOQOL-BREF (59.89 +/- 5.86 vs. 66.64 +/- 6.24, p < 0.001) and HADS psychological scores (p < 0.001). Conclusions: Combining NPWT with physiotherapy enhances functional recovery, reduces pain and anxiety, and improves quality of life. These findings support a multidisciplinary approach in acute wound management.
C1 [Stanciu, Cristina-Teodora] Victor Babes Univ Med & Pharm Timisoara, Doctoral Sch, Timisoara 300041, Romania.
   [Vaduva, Marcel Mihai Berceanu; Pop, Daniel Laurentiu; Vermesan, Dinu] Victor Babes Univ Med & Pharm Timisoara, Orthoped Traumatol Urol Radiol & Med Imaging Dept, Discipline Orthoped & Traumatol 1, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara
RP Vaduva, MMB (通讯作者)，Victor Babes Univ Med & Pharm Timisoara, Orthoped Traumatol Urol Radiol & Med Imaging Dept, Discipline Orthoped & Traumatol 1, Timisoara 300041, Romania.
EM cristina.stanciu@umft.ro; marcel.berceanu-vaduva@umft.ro;
   daniellaurentiupop@yahoo.com; dinu@vermesan.ro
FU Victor Babes University of Medicine and Pharmacy; Victor Babes
   University of Medicine and Pharmacy for paying the APC
FX We acknowledge the Victor Babes University of Medicine and Pharmacy for
   paying the APC.
CR Altman DG, 2005, BMJ-BRIT MED J, V331, P903, DOI 10.1136/bmj.331.7521.903
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NR 37
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD MAR 24
PY 2025
VL 13
IS 4
AR 785
DI 10.3390/biomedicines13040785
PG 16
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 1ZV9X
UT WOS:001477587100001
PM 40299354
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tedesco, S
   Di Grezia, M
   Tropeano, G
   Altieri, G
   Brisinda, G
AF Tedesco, Silvia
   Di Grezia, Marta
   Tropeano, Giuseppe
   Altieri, Gaia
   Brisinda, Giuseppe
TI Necrotizing soft tissue infections: a surgical narrative review
SO UPDATES IN SURGERY
LA English
DT Review
DE Humans; Soft tissue infections/therapy/diagnosis; Debridement;
   Anti-bacterial agents/therapeutic use; Necrosis; Fasciitis,
   Necrotizing/therapy/diagnosis; Negative pressure wound therapy
ID INTENSIVE-CARE; FASCIITIS; MORTALITY; SKIN; MULTICENTER; MANAGEMENT;
   DEBRIDEMENT; DIAGNOSIS; OUTCOMES
AB Necrotizing soft tissue infections represent a spectrum of diseases characterized by extensive necrosis involving the skin, subcutaneous tissues, fascia or muscles. These infections are generally severe and rapidly progressive, often accompanied by sepsis, septic chock, multiple organ failure and, ultimately, death. Several classifications have been developed based on multiple parameters, such as the anatomical location of the disease, the depth of the lesion or the microbiology. Numerous clinical factors predispose individuals to the development of necrotizing soft tissue infections. The clinical presentation is not always characterized by local signs and systemic symptoms of infection, which can lead to delays in both diagnosis ad treatment. Broad-spectrum antibiotic directed at the likely organisms is essential early in the treatment course, but do not substitute surgical management. Antibiotic therapy should be subsequently tailored to the etiologic micro-organism. Rapid recognition and early surgical intervention form the mainstay of management of necrotizing soft tissue infections. Initial surgical debridement should be promptly performed preferably at the presenting hospital, when adequate infrastructure and personnel are available. Transfer to a referral center may be necessary for definitive surgical and complex wound care. Most patients require more than one debridement. A multidisciplinary approach is also essential to improve the results in the treatment of these patients.
C1 [Tedesco, Silvia; Di Grezia, Marta; Tropeano, Giuseppe; Altieri, Gaia; Brisinda, Giuseppe] Fdn Policlin Univ A Gemelli, Emergency Surg & Trauma Ctr, Dept Med & Surg Sci, IRCS, I-00168 Rome, Italy.
   [Brisinda, Giuseppe] Agostino Gemelli, Catholic Sch Med, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Brisinda, G (通讯作者)，Fdn Policlin Univ A Gemelli, Emergency Surg & Trauma Ctr, Dept Med & Surg Sci, IRCS, I-00168 Rome, Italy.; Brisinda, G (通讯作者)，Agostino Gemelli, Catholic Sch Med, I-00168 Rome, Italy.
EM giuseppe.brisinda@policlinicogemelli.it
RI ; Brisinda, Giuseppe/G-6436-2010
OI Tedesco, Silvia/0000-0003-4693-4725; Tropeano,
   Giuseppe/0000-0001-9006-5040; Brisinda, Giuseppe/0000-0001-8820-9471
FU Universita Cattolica del Sacro Cuore within the CRUI-CARE Agreement
FX Open access funding provided by Universita Cattolica del Sacro Cuore
   within the CRUI-CARE Agreement. This research did not receive any
   specific grant from funding agencies in the public, commercial, or
   not-for-profit sectors.
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   Yadav K, 2024, CAN J EMERG MED, DOI 10.1007/s43678-024-00737-w
   Zhang LY, 2024, BURNS, V50, P578, DOI 10.1016/j.burns.2023.11.008
NR 70
TC 17
Z9 21
U1 2
U2 5
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD AUG
PY 2025
VL 77
IS 4
BP 1239
EP 1251
DI 10.1007/s13304-025-02222-0
EA APR 2025
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 4YC9K
UT WOS:001477766400001
PM 40295449
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Yoon, TH
   Lee, HS
   Lee, CH
   Jeon, YH
AF Yoon, Tae-Hong
   Lee, Han Sol
   Lee, Chul Ho
   Jeon, Yun-Ho
TI Successful treatment of gastropulmonary fistula in a patient with
   gastric diverticulum: A case report
SO MEDICINE
LA English
DT Article
DE gastric diverticulum; gastropulmonary fistula
ID GASTROBRONCHIAL FISTULA; MANAGEMENT
AB Rationale:Gastropulmonary fistula (GPF) is defined as a communication pathway between the stomach and the lung. GPF is a rare condition, and there is no consensus regarding its treatment. GPF has been reported in only a small number of cases.Patient concerns:A 61-year-old male patient visited the emergency room due to abdominal pain and concurrent hematemesis that started 2 days prior. The patient reported a history of frequent vomiting attributed to chronic alcoholism and gastric ulcer-related bleeding. Multiple gastric ulceration and gastric diverticulum were diagnosed at that time.Diagnoses:GPF was diagnosed by a noncontrast-enhanced chest computed tomography scan after swallowing an oral contrast agent.Interventions:GPF was treated with surgical intervention. A left lower lobectomy was performed through a posterolateral thoracotomy at the left 6th intercostal space. The 2.5 cm diaphragmatic opening was closed using a pledgeted 2-0 Prolene suture. In the abdomen, a partial gastrectomy was performed via an upper median laparotomy.Outcomes:Successful surgical management of a PGF. Postoperative pneumonia developed on postoperative day (POD) 3, prompting a change in antibiotics. On POD20, an abdominal wound infection occurred, for which a vacuum-assisted closure system was applied. The patient began oral intake on POD33 and was discharged on POD56 after the removal of the tracheostomy tube.Lessons:This case demonstrates that surgical intervention should be considered the primary treatment option when managing a patient diagnosed with GPF.
C1 [Yoon, Tae-Hong; Lee, Han Sol; Lee, Chul Ho; Jeon, Yun-Ho] Daegu Catholic Univ, Sch Med, Dept Thorac & Cardiovasc Surg, 33 Duryugongwon Ro 17 Gil, Daegu, South Korea.
C3 Catholic University of Daegu
RP Jeon, YH (通讯作者)，Daegu Catholic Univ, Sch Med, Dept Thorac & Cardiovasc Surg, 33 Duryugongwon Ro 17 Gil, Daegu, South Korea.
EM drdrumhong@naver.com; poohrooh@naver.com; poohrooh@naver.com;
   yunja0129@naver.com
OI chul ho, Lee/0000-0002-9139-0619; Jeon, Yun-Ho/0000-0002-5283-3261; LEE,
   HANSOL/0000-0003-1916-2926; Yoon, Tae-hong/0000-0002-4609-3498
CR Ben Nun A, 2018, WORLD J SURG, V42, P1792, DOI 10.1007/s00268-017-4358-z
   Guillaud A, 2015, OBES SURG, V25, P2352, DOI 10.1007/s11695-015-1702-y
   Janilionis Ricardas, 2016, Acta Med Litu, V23, P169, DOI [10.6001/actamedica.v23i3.3381, 10.6001/actamedica.v23i3.3381]
   Lee Seong Kwang, 2010, The Korean Journal of Thoracic and Cardiovascular Surgery, V43, P340
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   van de Vrande S, 2013, SURG OBES RELAT DIS, V9, P856, DOI 10.1016/j.soard.2013.01.003
NR 9
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR 18
PY 2025
VL 104
IS 16
AR e42152
DI 10.1097/MD.0000000000042152
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2GH5K
UT WOS:001481964200007
PM 40258765
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Saramago, P
   Gkekas, A
   Arundel, CE
   Chetter, IC
AF Saramago, Pedro
   Gkekas, Athanasios
   Arundel, Catherine E.
   Chetter, Ian C.
CA SWHSI-2 Trial Investigators
TI Negative pressure wound therapy for surgical wounds healing by secondary
   intention is not cost-effective
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Article
ID GROIN
AB Background Negative pressure wound therapy (NPWT) has been used in clinical practice for surgical wounds healing by secondary intention (SWHSI), despite limited evidence regarding its clinical effectiveness and cost-effectiveness. The aim of this study was to evaluate the cost-effectiveness of NPWT for SWHSI, compared with standard dressings, from the perspective of the UK healthcare system. Methods An economic model was used to extrapolate the effectiveness results of a meta-analysis over a patient's lifetime and estimate the costs and outcomes (quality-adjusted life-years (QALYs)) of NPWT and standard dressings. The probability of NPWT being cost-effective was estimated, with extensive scenario analyses conducted to evaluate the robustness of results and the degree of uncertainty. Results On average, NPWT was associated with higher costs and marginally higher QALYs than standard dressings. The cost difference was mainly driven by the additional intervention costs associated with NPWT. The estimated probability of NPWT being cost-effective was <30%. There was considerable uncertainty in the findings, driven largely by uncertainty in the estimated pooled relative effect from the meta-analysis. Results were robust to different scenario analyses. Conclusion No evidence was found demonstrating that NPWT was a cost-effective alternative to standard dressings for SWHSI.
C1 [Saramago, Pedro] Univ York, Ctr Hlth Econ, Alcuin A Block, York YO10 5D, England.
   [Gkekas, Athanasios; Arundel, Catherine E.] Univ York, York Trials Unit, York, England.
   [Chetter, Ian C.] Univ Hull, Fac Hlth Sci, Kingston Upon Hull, England.
   [Chetter, Ian C.] Hull York Med Sch, Kingston Upon Hull, England.
   [Chetter, Ian C.] Hull Univ Teaching Hosp NHS Trust, Kingston Upon Hull, England.
C3 University of York - UK; University of York - UK; University of Hull;
   University of Hull; University of York - UK
RP Saramago, P (通讯作者)，Univ York, Ctr Hlth Econ, Alcuin A Block, York YO10 5D, England.
EM pedro.saramago@york.ac.uk
OI Gkekas, Athanasios/0000-0003-4357-9043; Arundel,
   Catherine/0000-0003-0512-4339; chetter, ian/0000-0002-2566-6859
FU National Institute for Health and Care Research; Hull University
   Teaching Hospitals NHS Trust
FX The authors would like to thank: the study participants who kindly
   agreed to take part in this study and the patient and public involvement
   representatives (D. Butler, D. Smith, and B. Alleyway), whose input was
   indispensable in developing study documentation; all participating site
   staff at each site involved in the study and staff who have supported
   the delivery of the SWHSI-2 study at the York Trials Unit, University of
   York (J. McCaffery, H. Rodrick, V. Exley, S. Rodgers, and C. Peck) and
   the Hull University Teaching Hospitals NHS Trust (C Acey and J. Long);
   and the Trial Steering Committee (Professor Richard Grieve (Chair), Mr
   Tristan Lane, Professor Dileep Lobo, Professor Judith Tanner, Margaret
   Ogden, and Peter Wheatstone) and the Data Monitoring Committee
   (Professor Peter Holt (Chair), Sarah Brown, and Professor Andrea Nelson)
   for their support, oversight, and input during the study.
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   RStudio, Chocolate Cosmos Release 2024
   Saramago P, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-105
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   Zens Y, 2020, SYST REV-LONDON, V9, DOI 10.1186/s13643-020-01476-6
NR 31
TC 6
Z9 8
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD MAY
PY 2025
VL 112
IS 5
AR znaf077
DI 10.1093/bjs/znaf077
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2GH5S
UT WOS:001481965000001
PM 40326752
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Ross, K
   Zinck, N
   Wilson, D
   Rasmussen, J
   Biddulph, M
   Williams, J
AF Ross, Katie
   Zinck, Nicholas
   Wilson, David
   Rasmussen, Jack
   Biddulph, Michael
   Williams, Jason
TI Integra Dermal Regeneration Template in Reconstruction of Primary
   Oncologic Defects in the Lower Extremities: A Case Series
SO PLASTIC SURGERY
LA English
DT Article
DE integra dermal regeneration template; integra; reconstruction; oncology;
   extremity; matrice de r & eacute;g & eacute;n & eacute;ration dermique
   Integra; oncologie; extr & eacute;mit & eacute;
ID MATRIX
AB This article presents a case series of 4 patients who underwent primary reconstruction of oncologic defects in the lower extremities using Integra Dermal Regeneration Template (IDRT). The patients had either primary or recurrent tumors, which resulted in exposure of deep underlying structures including tendon, nerve, muscle, and bone. IDRT was selected to manage these defects due to the uncertain malignant potential of tissue margins and its ability to facilitate later margin revision without sacrificing tissue. The use of IDRT allowed for the growth of a neodermis that supported subsequent split-thickness skin grafting in all cases. Additionally, for those with positive margins, surgical revision and skin graft application was able to be performed in a single procedure, maximizing operating room use and patient convenience. This case series highlights the potential of IDRT in managing complex oncologic defects in the lower extremities, expanding options for reconstructive surgeons. Key findings: (1) IDRT is a viable option for reconstruction in oncologic resections exposing deep structures. (2) In cases with unknown malignant potential of tissue margins, use of IDRT can allow for revision of positive margins without sacrificing graft or flap tissue. (3) Negative pressure wound therapy is an important adjunct in achieving a favorable neodermis for acceptance of a spilt thickness skin graft.
C1 [Ross, Katie; Rasmussen, Jack; Williams, Jason] Dalhousie Univ, Dept Surg, Div Plast Surg, 1796 Summer St, Room 4447, Halifax, NS B3H 3A7, Canada.
   [Zinck, Nicholas] Dalhousie Univ, Fac Med, Halifax, NS, Canada.
   [Wilson, David; Biddulph, Michael] Dalhousie Univ, Dept Surg, Div Orthoped Surg, Halifax, NS, Canada.
   [Rasmussen, Jack] Dalhousie Univ, Dept Crit Care Med, Halifax, NS, Canada.
C3 Dalhousie University; Dalhousie University; Dalhousie University;
   Dalhousie University
RP Ross, K (通讯作者)，Dalhousie Univ, Dept Surg, Div Plast Surg, 1796 Summer St, Room 4447, Halifax, NS B3H 3A7, Canada.
EM katie.ross@dal.ca
OI Wilson, David/0000-0001-8372-3041; Ross, Katie/0009-0000-4795-2410
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
   Chang DK, 2019, SEMIN PLAST SURG, V33, P185, DOI 10.1055/s-0039-1693401
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   Hughes LP, 2021, PRS-GLOB OPEN, V9, DOI 10.1097/GOX.0000000000003340
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   Shah A, 2022, CASE REP PLAST SURG, V9, P75, DOI 10.1080/23320885.2022.2047052
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   Wang JCY, 2000, BRIT J PLAST SURG, V53, P70, DOI 10.1054/bjps.1999.3201
   Zhu BZ, 2021, J PLAST SURG HAND SU, V55, P1, DOI 10.1080/2000656X.2020.1781140
NR 16
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2292-5503
EI 2292-5511
J9 PLAST SURG-CHIR PLAS
JI Plast. Surg.
PD MAY
PY 2026
VL 34
IS 2
BP 354
EP 360
DI 10.1177/22925503251336254
EA MAY 2026
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GM4FJ
UT WOS:001483484000001
PM 40352380
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Ma, J
   Zhang, X
AF Ma, Jia
   Zhang, Xin
TI The Impacts of Negative Pressure Wound Therapy on Patients with Cancer
   Surgical Wounds: Systematic Review and Meta-Analysis
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Review
DE surgical wound infection; cancer; patient readmission; negative-pressure
   wound therapy; seroma
ID SITE INFECTION; HIGH-RISK; SURGERY; COMPLICATIONS; LAPAROTOMY
AB Background: Cancer is a prevalent medical condition that frequently requires surgical intervention. As a result, the management of surgical wounds in cancer patients becomes a pivotal aspect of nursing care. This meta-analysis explores the effects of negative pressure wound therapy (NPWT), a cutting-edge wound management technique, on healing outcomes in cancer-related surgical wounds. Methods: This systematic review and meta-analysis included randomized clinical trials comparing NPWT with standard wound care in cancer patients. Key outcomes assessed were surgical site infection (SSI), seroma formation, and hospital readmission. Only trials that reported these outcomes in cancer-related surgical wounds were considered eligible. Results: A total of 10 randomized trials involving 1,322 patients with surgical wounds were included in the analysis. Across all cancer types, NPWT did not demonstrate statistically significant advantages compared to conventional wound care in reducing: Surgical site infections: p = 0.11; Seroma formation: p = 0.38; Hospital readmissions: p = 0.68. However, subgroup analysis revealed a notable exception: NPWT significantly reduced the incidence of surgical site infections in colorectal cancer patients (p = 0.0002). Conclusion: The findings suggest that NPWT may offer targeted benefits, particularly for colorectal cancer patients, by lowering the risk of postoperative infections. However, for other cancer types, NPWT did not demonstrate significant improvements in SSI, seroma, or hospital readmission rates compared to standard care. This highlights the need for further research to determine the contexts in which NPWT can be most beneficial in cancer wound management.
C1 [Ma, Jia] Hangzhou Canc Hosp, Dept Comprehens Care, Hangzhou 310002, Zhejiang, Peoples R China.
   [Zhang, Xin] HangZhou Canc Hosp, Dept Radiat Oncol, Hangzhou 310002, Zhejiang, Peoples R China.
RP Zhang, X (通讯作者)，HangZhou Canc Hosp, Dept Radiat Oncol, Hangzhou 310002, Zhejiang, Peoples R China.
EM zhangxin12345abc@outlook.com
CR Abd El Aziz MA, 2021, AM J SURG, V222, P20, DOI 10.1016/j.amjsurg.2020.12.012
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NR 23
TC 1
Z9 1
U1 1
U2 1
PU TAIWAN SOC GERIATRIC EMERGENCY & CRITICAL CARE MEDICINE-TSGECM
PI TAIPEI
PA 12F-14, NO 42, SEC 1, MINSHENG E RD, ZHONGSHAN DIST, TAIPEI, 104, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD APR
PY 2025
VL 19
IS 2
BP 64
EP 69
DI 10.6890/IJGE.202504_19(2).0001
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 2JI9T
UT WOS:001484040500004
DA 2026-07-24
ER
PT J
AU Escobar-Domingo, MJ
   Bustos, VP
   Mahmoud, AA
   Tobin, MJ
   Park, JB
   Lee, DNL
   Rahmani, B
   Knerr, RM
   Merle, C
   Bloom, JA
   Lin, SJ
   Lee, BT
AF Escobar-Domingo, Maria J.
   Bustos, Valeria P.
   Mahmoud, Amir-Ala
   Tobin, Micaela J.
   Park, John B.
   Lee, Daniela
   Rahmani, Benjamin
   Knerr, Reinhard M.
   Merle, Chamilka
   Bloom, Joshua A.
   Lin, Samuel J.
   Lee, Bernard T.
TI Impact of closed-incision negative pressure therapy in donor-site
   complications in DIEP flap breast reconstruction: Analysis of 705
   patients and 1125 flaps
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Breast Neoplasm; Free Tissue Flaps; Negative Pressure Wound Therapy;
   Female; Postoperative Complications; Retrospective Studies
ID ABDOMINAL-WALL RECONSTRUCTION; WOUND THERAPY; INFECTIONS; DEHISCENCE;
   PERFORATOR; MANAGEMENT; EFFICACY
AB Background: Closed-incision negative pressure therapy (ciNPT) has been shown to reduce complication rates in breast reconstruction (BR). This study aimed to evaluate postoperative outcomes in deep inferior epigastric perforator (DIEP) donor-site incisions managed with ciNPT compared to standard dressings. Methods: We performed a retrospective study of patients >= 18 years who underwent DIEP flap BR from 2015 to 2023. Patients who underwent reconstruction with alternative flaps or converted to transverse rectus abdominus myocutaneous were excluded. Patients were categorized according to the use of ciNPT vs. standard dressings. The unpaired t- and Fisher's Exact tests were used to assess the differences between the groups. Multivariable logistic regression models were used to evaluate postoperative complications. Results: A total of 705 patients were included, with 68 (9.6%) managed with ciNPT. Patients treated with ciNPT had significantly higher mean body mass index (BMI) (34.0 vs. 28.5 kg/m2; p < 0.001) compared to the control group. Higher rates of alcohol use (59.2% vs. 41.2%; p=0.006) and hormonal therapy use (41.3% vs. 17.9%; p < 0.001) were found in the standard dressing group. Univariate analyses showed no significant differences in donor-site postoperative outcomes across the groups. However, multivariate logistic regression models demonstrated a reduced likelihood of surgical site infection (OR 0.187; 95% CI 0.045-0.768); p=0.020), and wound dehiscence (OR 0.338; 95% CI 0.155-0.738); p=0.006) among the ciNPT users. Particularly, in patients with BMI > 30 kg/m2, ciNPT use (OR 0.282; 95% CI 0.098-0.812; p=0.019) was found to be a significant protective factor against wound complications compared to the standard of care. Conclusions: Our findings suggest that ciNPT may improve wound complication rates in DIEP flap donor sites, especially in patients with high BMI. Further research is necessary to elucidate the cost-effectiveness of ciNPT based on the patient risk profiles. (c) 2025 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Escobar-Domingo, Maria J.; Mahmoud, Amir-Ala; Tobin, Micaela J.; Park, John B.; Lee, Daniela; Rahmani, Benjamin; Knerr, Reinhard M.; Merle, Chamilka; Bloom, Joshua A.; Lin, Samuel J.; Lee, Bernard T.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Plast & Reconstruct Surg, Boston, MA USA.
   [Bustos, Valeria P.] Univ Miami, Dept Surg, Div Plast & Reconstruct Surg, Miami, FL USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; University of Miami
RP Lin, SJ; Lee, BT (通讯作者)，110 Francis St, Boston, MA 02215 USA.
EM sjlin@bidmc.harvard.edu; blee3@bidmc.harvard.edu
RI Escobar-Domingo, María José/JGE-5721-2023; Bloom, Joshua/W-6427-2019;
   Lin, Samuel/P-6158-2019; Lee, Bernard/K-1106-2016
OI Escobar-Domingo, María José/0000-0002-4677-471X; Merle,
   Chamilka/0000-0001-5744-1251; Bloom, Joshua/0000-0001-6413-3986; Lee,
   Daniela/0000-0002-1057-5380; Tobin, Micaela/0000-0002-8905-3250; 
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
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   [Anonymous], 2023, Plastic Surgery Statistics Report
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   Bloom JA, 2023, AM SURGEON, V89, P2237, DOI 10.1177/00031348221087395
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   Cooper HJ, 2023, PRS-GLOB OPEN, V11, DOI 10.1097/GOX.0000000000004722
   Doval AF, 2021, WOUNDS, V33, P81
   Dunson B, 2023, PRS-GLOB OPEN, V11, DOI 10.1097/GOX.0000000000005326
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   Siegwart LC, 2022, MICROSURG, V42, P32, DOI 10.1002/micr.30683
   Song JY, 2023, INT WOUND J, V20, P241, DOI 10.1111/iwj.13866
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   Swanson EW, 2016, PLAST SURG-CHIR PLAS, V24, P113, DOI 10.1177/229255031602400207
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   Zhang DH, 2023, INT WOUND J, V20, P46, DOI 10.1111/iwj.13835
NR 40
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JUN
PY 2025
VL 105
BP 177
EP 184
DI 10.1016/j.bjps.2025.04.010
EA JAN 2025
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2KA2N
UT WOS:001484491600001
PM 40305888
DA 2026-07-24
ER
PT J
AU Niu, BB
   Xu, JJ
   Li, JA
   Zhu, LD
AF Niu, Bei-bei
   Xu, Jing-jing
   Li, Ji-an
   Zhu, Ling-dong
TI Case report: Cervical suppurative lymphadenitis caused by burkholderia
   multivorans in a healthy child
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Cervical suppurative lymphadenitis; Burkholderia multivorans; Healthy
   child; Precise diagnosis; Granulomatous inflammation
AB BackgroundCervical suppurative lymphadenitis in children is commonly caused by Staphylococcus aureus or Streptococcus pyogenes. However, cases caused by Burkholderia multivorans (BM) are rare. The clinical presentation lacks specificity, making it difficult for clinicians to recognize, which may delay diagnosis and treatment.Case presentationWe report a case of a 5-year-old boy admitted with recurrent fever and neck swelling. Initial treatment with meropenem and linezolid was ineffective, and symptoms persisted after 24 days of conservative therapy. Aspiration of pus yielded negative culture results. Definitive diagnosis was achieved through surgical biopsy of cervical lymph nodes, pathological examination, and metagenomic next-generation sequencing (mNGS), which identified BM as the causative pathogen. The patient was successfully treated with a combination of trimethoprim-sulfamethoxazole and meropenem. The cervical lesion exhibited granulomatous inflammation and was managed with adjunctive vacuum-assisted closure (VAC) therapy, resulting in complete wound healing without recurrence.ConclusionsThis study aims to raise awareness among all specialists about BM as a potential causative agent in cervical suppurative lymphadenitis. Early recognition and timely intervention can reduce misdiagnosis and missed diagnoses, improving patient outcomes.
C1 [Niu, Bei-bei; Xu, Jing-jing; Zhu, Ling-dong] Shandong Univ, Jinan Childrens Hosp, Childrens Hosp, Dept Plast & Burn Surg, Jingshi St 23976, Jinan 250000, Shandong, Peoples R China.
   [Li, Ji-an] Shandong Univ, Jinan Childrens Hosp, Childrens Hosp, Infect Dis Dept, Jinan, Shandong, Peoples R China.
C3 Shandong University; Shandong University
RP Zhu, LD (通讯作者)，Shandong Univ, Jinan Childrens Hosp, Childrens Hosp, Dept Plast & Burn Surg, Jingshi St 23976, Jinan 250000, Shandong, Peoples R China.
EM zhuld@etyy.com
OI Niu, Beibei/0009-0003-2104-2728
FU Natural Science Foundation of Shandong Province
FX Special thanks to all authors who contributed to the research.
CR Al-Dajani N, 2007, INFECT DIS CLIN N AM, V21, P523, DOI 10.1016/j.idc.2007.03.004
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NR 17
TC 1
Z9 1
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD MAY 8
PY 2025
VL 25
IS 1
AR 678
DI 10.1186/s12879-025-11033-y
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 2KX7H
UT WOS:001485103400006
PM 40340931
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chang, CD
   Rodriguez-Mantilla, I
   Herrera, AC
   Molina, LA
   D'Amico, GA
   Berner, JE
   Marcasciano, M
   Chen, HC
AF Chang, Chad
   Rodriguez-Mantilla, Ivan
   Herrera, Andres Camilo
   Molina, Luis Arturo
   D'Amico, Giuseppe Antonio
   Berner, Juan Enrique
   Marcasciano, Marco
   Chen, Hung-Chi
TI Donor site in anterolateral thigh (ALT) free flaps: A systematic review
   of closure techniques and introduction of a management algorithm
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Anterolateral thigh flap; ALT flap; Closure technique; Donor site
ID TISSUE; MORBIDITY; REPAIR
AB The anterolateral thigh (ALT) free flap is widely used in reconstructive microsurgery for its versatility and reliability, yet donor site management becomes challenging when flap dimensions exceed those for tension-free primary closure. The flap width-to-thigh circumference ratio (FW/TCR) is a potentially valuable objective decision-making tool. Given the heterogeneity of the reported closure techniques, this review aimed to map current techniques, identify gaps in evidence and propose a FW/TCR-based algorithm to standardise ALT donor site closure. A review of PubMed/MEDLINE, EMBASE, Cochrane Library and AMED databases was conducted from inception to October 2023, including English-language studies focused on ALT donor site closures. Data on closure techniques, outcomes, and complications were extracted. Overall, 27 studies met the inclusion criteria, describing direct primary closure, locoregional flaps, skin grafting, and adjunctive methods such as negative pressure wound therapy, acellular dermal matrices and tissue expansion. Direct primary closure was generally reported as feasible for FW/TCR < 16%. Once FW/TCR exceeded 30%, skin grafting or alternative solutions such as 'kiss' (split skin paddle) flaps were more frequently described. In the intermediate range (16-30%), locoregional flaps were commonly employed to avoid graft-related morbidity. Drawing on these findings, we propose a FW/TCR-based algorithm: (1) direct closure for FW/TCR < 16%, (2) locoregional flaps for FW/TCR 16-30%, and (3) grafting or alternative techniques if FW/TCR exceeds 30%. Standardising closure strategies using these thresholds may reduce donor site morbidity and optimise patient outcomes. Further high-level comparative studies are necessary to validate and refine these recommendations. (c) 2025 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Chang, Chad; Rodriguez-Mantilla, Ivan; Marcasciano, Marco; Chen, Hung-Chi] China Med Univ Hosp, Dept Surg, Div Plast & Reconstruct Surg, Taichung, Taiwan.
   [Chang, Chad] Royal Victoria Infirm, Dept Plast & Reconstruct Surg, Queen Victoria Rd, Newcastle Upon Tyne, England.
   [Rodriguez-Mantilla, Ivan] Hosp San Jose, Fdn Univ Ciencias Salud, Dept Plast & Reconstruct Surg, Bogota, Colombia.
   [Herrera, Andres Camilo; Molina, Luis Arturo] Univ Rosario, Sch Med, Bogota, Colombia.
   [Herrera, Andres Camilo] Clin Univ Colombia, Dept Plast & Reconstruct Surg, Bogota, Colombia.
   [Molina, Luis Arturo] Univ El Bosque, Dept Epidemiol, Bogota, Colombia.
   [D'Amico, Giuseppe Antonio; Marcasciano, Marco] Magna Graecia Univ Catanzaro, Unit Plast & Reconstruct Surg, Dept Expt & Clin Med, Catanzaro, Italy.
   [D'Amico, Giuseppe Antonio] Univ Hosp Messina AOU Gaetano Martino, Dept Plast & Reconstruct Surg, Messina, Italy.
   [Berner, Juan Enrique] Univ Texas Hlth Sci Ctr San Antonio, Div Plast & Reconstruct Surg, Dept Surg, San Antonio, TX USA.
   [Chen, Hung-Chi] China Med Univ Hosp, Int Ctr, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; Newcastle University - UK; Fundacion Universitaria de Ciencias
   de la Salud (FUCS); Universidad del Rosario; Universidad El Bosque;
   Magna Graecia University of Catanzaro; University of Texas System;
   University of Texas at San Antonio; China Medical University Taiwan;
   China Medical University Hospital - Taiwan
RP Chang, CD (通讯作者)，Royal Victoria Infirm, Dept Plast & Reconstruct Surg, Queen Victoria Rd, Newcastle Upon Tyne, England.
EM Changchad@doctors.org.uk
RI ; Chang, Chad/GNH-6300-2022; Berner, Juan Enrique/AAI-1244-2021;
   Marcasciano, Marco/HZJ-0259-2023
OI D’Amico, Giuseppe Antonio/0009-0005-1540-2357; Chang,
   Chad/0000-0003-2908-0318; Molina, Luis Arturo/0009-0007-3211-1206;
   Berner, Juan Enrique/0000-0003-2178-5161; 
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NR 31
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JUN
PY 2025
VL 105
BP 243
EP 259
DI 10.1016/j.bjps.2025.04.008
EA MAY 2025
PG 17
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2LG6N
UT WOS:001485338200002
PM 40318362
DA 2026-07-24
ER
PT J
AU Kong, CG
   Park, JB
AF Kong, Chae-Gwan
   Park, Jong-Beom
TI Postoperative Infection After Esophageal Injury in Anterior Cervical
   Spine Surgery: A Comprehensive Review of Diagnosis, Management, and
   Outcomes
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE postoperative complications; esophageal injury; cervical spine
   infection; surgical management; infection control; rehabilitation
ID STERNOCLEIDOMASTOID MUSCLE FLAP; PERFORATION; REPAIR; FUSION; CEMENT
AB Postoperative infection following anterior cervical spine surgery, particularly when complicated by esophageal injury, is a rare but serious condition associated with significant morbidity and mortality. This review elucidates the complex interplay between postoperative infection and esophageal injury. We systematically analyzed studies from 2000 to 2025 using PubMed, Scopus, and Web of Science, focusing on infection, esophageal injury, surgical outcomes, and management strategies, with emphasis on recent advances in diagnostics, surgical techniques, and postoperative care. Our findings highlight the multifactorial nature of these complications and the critical role of early recognition, accurate diagnosis, and timely management. Imaging modalities such as CT, MRI, and contrast esophagography, along with flexible esophagoscopy, are indispensable in assessing injury and infection extent. Effective management requires a multidisciplinary approach integrating broad-spectrum antibiotics, surgical debridement, vascularized flap reinforcement, negative pressure wound therapy, and antibiotic-loaded cement beads. Meticulous postoperative care with prolonged antibiotics, nutritional support, and imaging follow-up is vital for optimizing outcomes. Innovative approaches, including vascularized muscle flaps and hyperbaric oxygen therapy, show promise in enhancing healing and reducing infections. Our review underscores the need for future meta-analyses to strengthen evidence and refine protocols. As surgical techniques evolve, so too must our diagnostic, surgical, and postoperative strategies to minimize complications and improve patient outcomes.
C1 [Kong, Chae-Gwan; Park, Jong-Beom] Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Orthopaed Surg, Coll Med, Uijongbu 11765, South Korea.
C3 Catholic University of Korea
RP Park, JB (通讯作者)，Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Orthopaed Surg, Coll Med, Uijongbu 11765, South Korea.
EM gongjae@catholic.ac.kr; spinepjb@catholic.ac.kr
OI Park, Jong-Beom/0000-0001-8273-3731; Kong, Chae-gwan/0000-0003-4237-4556
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NR 36
TC 4
Z9 5
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY 7
PY 2025
VL 14
IS 9
AR 3244
DI 10.3390/jcm14093244
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2MZ8B
UT WOS:001486517200001
PM 40364274
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Millán-Reyes, MJ
   Afanador-Restrepo, DF
   Carcelén-Fraile, MD
   Aibar-Almazán, A
   Sánchez-Alcalá, M
   Cano-Sánchez, J
   Mesas-Aróstegui, MA
   Castellote-Caballero, Y
AF Millan-Reyes, Maria Juana
   Afanador-Restrepo, Diego Fernando
   Carcelen-Fraile, Maria del Carmen
   Aibar-Almazan, Agustin
   Sanchez-Alcala, Marcelina
   Cano-Sanchez, Javier
   Mesas-Arostegui, Maria Aurora
   Castellote-Caballero, Yolanda
TI Reducing Infections and Improving Healing in Complex Wounds: A
   Systematic Review and Meta-Analysis
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE chronic wounds; traumatic injuries; wound healing; surgical site
   infections
ID SURGICAL-SITE INFECTIONS; THERAPY; PREVENTION; TRIAL; MANAGEMENT;
   FRACTURES; DRESSINGS; IRRIGATION; CARE
AB Background and Objectives: Wound management in complex and traumatic injuries remains a significant clinical challenge, with a high risk of surgical site infections (SSIs) and associated complications. This systematic review and meta-analysis aim to evaluate the effectiveness of diverse interventions, including Negative Pressure Wound Therapy (NPWT), advanced dressings, irrigation techniques, antibiotic regimens, and innovative therapies, in improving wound healing outcomes and reducing infection rates. Materials and Methods: An exhaustive literature search focused on the use of NPWT, dressings, and antibiotics in the care of chronic wounds was conducted following PRISMA guidelines in the PubMed, Scopus, Web of Science, and CINAHL databases. Eligible studies included randomized controlled trials and prospective cohorts assessing interventions for wound care in trauma, surgical, and chronic wound settings. The risk of bias was assessed using the ROB2 tool. Subgroup analyses were performed to evaluate the relative risk (RR) of infections based on the intervention type. Results: The analysis included 17 studies spanning diverse geographical and clinical settings. NPWT demonstrated significant benefits in reducing infection rates compared to control groups (RR: 0.590, 95% CI: 0.458-0.760, and p < 0.001). Although advanced dressings demonstrated clinically relevant benefits as reported across the included studies, the meta-analysis did not reveal statistically significant differences (RR: 0.516, 95% CI: 0.242-1.100, and p = 0.087). Antibiotic therapies significantly reduced infections when administered within 24 h of injury, while low-pressure irrigation techniques effectively minimized bacterial contamination without causing tissue damage. Growth factors and honey-based treatments exhibited promising results in accelerating wound healing and reducing infection risks in chronic wounds. Conclusions: NPWT emerges as a highly effective intervention for infection prevention and wound healing, supported by robust evidence. Advanced dressings and innovative therapies show potential but require further research for conclusive evidence. These findings underscore the importance of tailoring wound care strategies to the clinical context and patient needs. Future research should focus on long-term outcomes and cost-effectiveness analyses to enhance the integration of these therapies into clinical practice.
C1 [Millan-Reyes, Maria Juana] Univ Hosp Jaen, Jaen 23007, Spain.
   [Millan-Reyes, Maria Juana; Aibar-Almazan, Agustin; Sanchez-Alcala, Marcelina; Cano-Sanchez, Javier] Univ Jaen, Fac Hlth Sci, Dept Hlth Sci, Jaen 23071, Spain.
   [Afanador-Restrepo, Diego Fernando] Univ Fdn Area Andina Pereira, Fac Hlth Sci & Sport, Pereira 660004, Colombia.
   [Afanador-Restrepo, Diego Fernando] Antonio Jose Camacho Univ Inst, Fac Distance & Virtual Educ, Santiago de Cali 760016, Colombia.
   [Carcelen-Fraile, Maria del Carmen] Univ Atlant Medio, Fac Social Sci, Dept Educ Sci, Las Palmas Gran Canaria 35017, Spain.
   [Mesas-Arostegui, Maria Aurora] Hosp Quiron Marbella, Pediat Endocrinol Dept, Inst Hispalense Pediat, Malaga 29603, Spain.
   [Mesas-Arostegui, Maria Aurora] Hosp Guadix, Pediat Dept, Granada 18500, Spain.
   [Castellote-Caballero, Yolanda] Univ Atlant Medio, Fac Hlth Sci, Dept Hlth Sci, Las Palmas Gran Canaria 35017, Spain.
C3 Universidad de Jaen
RP Carcelén-Fraile, MD (通讯作者)，Univ Atlant Medio, Fac Social Sci, Dept Educ Sci, Las Palmas Gran Canaria 35017, Spain.
EM mjmr0013@red.ujaen.es; carmen.carcelen@pdi.atlanticomedio.es
RI Afanador, Diego Fernando/GLV-4428-2022; Carcelén Fraile, María del
   Carmen/GYJ-3589-2022; Aibar Almazán, Agustín/AAM-9109-2020;
   Afanador-Restrepo, Diego Fernando/GLV-4428-2022
OI Afanador, Diego Fernando/0000-0002-7958-0751; Carcelén Fraile, María del
   Carmen/0009-0000-9186-8865; Aibar Almazán, Agustín/0000-0002-9386-9199;
   , Javier Cano Sánchez/0009-0006-6262-7839; 
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NR 45
TC 15
Z9 16
U1 5
U2 11
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY 7
PY 2025
VL 14
IS 9
AR 3237
DI 10.3390/jcm14093237
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2NH3E
UT WOS:001486712500001
PM 40364268
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhao, EY
   Chen, MT
   Yang, H
   Ba, XQ
   Xu, LG
AF Zhao, Eryang
   Chen, Mantao
   Yang, Hu
   Ba, Xiaoqun
   Xu, Ligong
TI Multidisciplinary collaborative treatment of a giant malignant
   peripheral nerve sheath tumor on the top of the head: a case report
SO DISCOVER ONCOLOGY
LA English
DT Article
DE Malignant peripheral nerve sheath tumors (MPNSTs); Surgical resection;
   Case report
ID NECK
AB BackgroundMalignant peripheral nerve sheath tumors (MPNSTs) rarely occur on the top of the head. MPNSTs are usually characterized by invasiveness, recurrence, and metastasis.Case presentationHerein we report a 44-year-old female patient who received multidisciplinary collaborative treatment for a giant MPNST on the top of her head. The patient was initially evaluated in the Departments of Neurosurgery and Burn Plastic Surgery at our hospital. She then underwent elective surgery after psychological counseling. Surgeons from the Departments of Neurosurgery and Burn Plastic Surgery collaborated during the surgery. Specifically, surgeons from the Department of Neurosurgery excised the lesion with meticulous hemostasis under general anesthesia. Then, surgeons from the Department of Burn Plastic Surgery performed personalized skin grafting following a predetermined regimen, which consisted of the following steps: a razor-thin graft was harvested from the anterior thigh and transplanted to the target site to repair the scalp defect; and vacuum sealing drainage was performed. The patient was followed for 6 months postoperatively and had no signs of a recurrence. The patient was very satisfied with the treatment and outcome.ConclusionsComplete surgical resection is recommended for a giant MPNST on the top of the head. Patients should undergo a comprehensive evaluation of disease severity, general health status, and mental state preoperatively. The treatment regimen can be personalized through a multidisciplinary approach. Intraoperative blood loss should be closely monitored, along with regular postoperative follow-up evaluations to confirm treatment efficacy.
C1 [Zhao, Eryang] Shaoxing Univ Arts & Sci, Xinchang Cty Peoples Hosp, Dept Neurosurg, Xinchang Hosp, Shaoxing 312500, Peoples R China.
   [Chen, Mantao] Zhejiang Univ, Dept Neurosurg, Coll Med, Hosp 1, 79 Qingchun Rd, Hangzhou 310000, Zhejiang, Peoples R China.
   [Yang, Hu] Zhejiang Univ, Dept Plast Surg, Hosp 1, Hangzhou 310000, Peoples R China.
   [Ba, Xiaoqun] Zhejiang Univ, Pathol Dept, Hosp 1, Hangzhou 310000, Peoples R China.
   [Xu, Ligong] Zhejiang Univ, Radiol Dept, Hosp 1, Hangzhou 310000, Peoples R China.
C3 Shaoxing University; Zhejiang University; Zhejiang University; Zhejiang
   University; Zhejiang University
RP Chen, MT (通讯作者)，Zhejiang Univ, Dept Neurosurg, Coll Med, Hosp 1, 79 Qingchun Rd, Hangzhou 310000, Zhejiang, Peoples R China.
EM chenmantao0513@163.com
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NR 18
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
EI 2730-6011
J9 DISCOV ONCOL
JI Discov. Oncol.
PD MAY 10
PY 2025
VL 16
IS 1
AR 719
DI 10.1007/s12672-025-02554-8
PG 8
WC Oncology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Endocrinology & Metabolism
GA 2PC4Q
UT WOS:001487944200007
PM 40348863
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Guo, Q
AF Guo, Quan
TI Comparison and evaluation of negative pressure wound therapy versus
   standard wound care in the treatment of diabetic foot ulcers
SO BMC SURGERY
LA English
DT Article
DE Comparison; Evaluation; Negative pressure wound therapy; Standard wound
   care; Diabetic foot ulcers
ID MANAGEMENT; CHALLENGES; PERFUSION
AB Background To explore the efficacy, safety, and cost implications of NPWT versus standard wound care (SWC) for Diabetic Foot Ulcers (DFUs). Methods 91 patients with DFUs were included in this retrospective study from May 2017 and February 2024. All patients were divided into NPWT (n = 44) and SWC (n = 47) groups based on the surgery methods. Arterial disease severity was assessed via ankle-brachial index (ABI) and Doppler ultrasound, with subgroups categorized as severe ischemia (ABI < 0.4), moderate ischemia (ABI 0.4-0.7), and normal/mild ischemia (ABI > 0.7). Baseline characteristics, wound parameters, healing progression, adverse events, costs, and subgroup outcomes by arterial disease status were compared between two groups. Results At the 4-week assessment, the NPWT group exhibited significantly higher mean percentage reduction in wound area (35.01% vs. 32.53%, P = 0.033) and greater reduction in wound depth (2.74 mm vs. 2.14 mm, P = 0.032) compared to the SWC group. A notably higher proportion of NPWT patients achieved complete wound closure (52.27% vs. 27.66%, P = 0.029), resolution of infection (88.64% vs. 68.09%, P = 0.035), and neuropathy improvement (59.09% vs. 34.04%, P = 0.029). NPWT also showed lower wound infection rates (9.09% vs. 29.79%, P = 0.027) but higher skin irritation (31.82% vs. 10.64%, P = 0.026). Subgroup analysis revealed NPWT's superiority in both PAD-positive (48.0% vs. 20.0%, RR = 2.40, 95% CI: 1.12-5.15, P = 0.042) and PAD-negative subgroups (55.2% vs. 30.4%, RR = 1.82, 95% CI: 1.05-3.15, P = 0.031). Even in severe ischemia (ABI < 0.4), NPWT achieved higher closure rates (36.4% vs. 12.5%, P = 0.038). While total treatment costs were comparable (P = 0.084), NPWT reduced hospitalization days (16.05 vs. 21.38 days, P = 0.028) and drug costs (5229.33 RMB vs. 5915.5 RMB, P = 0.030). Conclusion NPWT is more superior in safety, cost-efficiency, and long-term wound management compared to SWC. Trial registrationNot applicable.
C1 [Guo, Quan] Univ South China, Cent Hosp Yongzhou, Dept Orthoped, Yongzhou Hosp, 396 Yiyun Rd, Yongzhou 425000, Hunan, Peoples R China.
C3 University of South China
RP Guo, Q (通讯作者)，Univ South China, Cent Hosp Yongzhou, Dept Orthoped, Yongzhou Hosp, 396 Yiyun Rd, Yongzhou 425000, Hunan, Peoples R China.
EM sinewoomph@hotmail.com
RI Guo, Quan/NUP-6934-2025
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   Yang L, 2022, WORLD J DIABETES, V13, P1014, DOI 10.4239/wjd.v13.i12.1014
NR 32
TC 6
Z9 6
U1 3
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD MAY 15
PY 2025
VL 25
IS 1
AR 208
DI 10.1186/s12893-025-02885-x
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2PY2N
UT WOS:001488515400002
PM 40369497
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Atfeh, J
   Guerre, P
   Carre, E
   Besse, JL
   Huot, L
AF Atfeh, Jamal
   Guerre, Pascale
   Carre, Emmanuelle
   Besse, Jean-Luc
   Huot, Laure
TI Incisional Negative Pressure Wound Therapy devices applied after Total
   Ankle Arthroplasty: A Hospital-Based Health Technology Assessment
SO PLOS ONE
LA English
DT Article
ID EVIDENCE-BASED RECOMMENDATIONS; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   SURGICAL INCISION; JOINT INFECTION; COMPLICATIONS; MANAGEMENT; SURGERY;
   MECHANISMS; DRESSINGS
AB Introduction A portable, single-use incisional Negative Pressure Wound Therapy (iNPWT) device could be used directly on the wound incision following Total Ankle Arthroplasty (TAA). In order to support local decision-making in a French university hospital for the adoption of such device in this indication, a three-dimensional (clinical, economic and organizational) Hospital Based-Health Technology Assessment (HB-HTA) was conducted.Materials and methods The HB-HTA was based on: a literature review; results from the PICO-PTC single-site randomized controlled trial (ClinicalTrial.gov identifier NCT03886818); and semi-structured interviews with healthcare professionals.Results Two comparative retrospective cohort studies were retrieved from the literature review. They suggested a decreased incidence of wound healing complications with iNPWT compared to standard dressings, although no difference was found in the PICO-PTC study. There was no significant difference in the PICO-PTC study on Medicine-Surgery-Obstetrics hospital costs between the two strategies: <euro>10,639.65 [CI 95% (7,997.45; 17,988.68)] in the iNPWT group versus <euro>9,672.59 [CI 95% (7,966.29; 13,393.65)] in the standard dressings group. Adoption of this prophylactic strategy would result in an approval to pay a 1.5% supplement to the Medicine-Surgery-Obstetrics hospitalization costs. It could also improve professionals' workflow, and facilitate wound healing monitoring for nurses in orthopedic departments compared to standard dressings.Conclusion The clinical effectiveness of the iNPWT single-use portable device could not be demonstrated compared to standard dressings for prophylactic use, in terms of the incidence of wound healing complications, in patients scheduled for TAA and not selected on the basis of risk factors. However, as this strategy may bring organizational benefits and has not been associated with significant economic costs, the adoption of iNPWT in orthopedic departments could be made according to the surgeon's clinical expertise, based for instance on the patient's risk factors for complications.
C1 [Atfeh, Jamal; Guerre, Pascale; Huot, Laure] Hosp Civils Lyon, Serv Evaluat Econ Sante, Pole Sante Publ, Lyon, France.
   [Atfeh, Jamal; Huot, Laure] Univ Lyon 1, Inserm U1290, Res Healthcare Performance RESHAPE, Lyon, France.
   [Guerre, Pascale] Univ Lyon 1, Lab Parcours Syst Sante, Lyon, France.
   [Carre, Emmanuelle] Hosp Civils Lyon, Pharm Cent, St Genis Laval, France.
   [Besse, Jean-Luc] Hop Lyon Sud, Serv Chirurg Orthoped & Traumatol, Hosp Civils Lyon, Pierre Benite, France.
C3 CHU Lyon; Universite Lyon 1; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Lyon 1; CHU Lyon; CHU Lyon
RP Atfeh, J (通讯作者)，Hosp Civils Lyon, Serv Evaluat Econ Sante, Pole Sante Publ, Lyon, France.; Atfeh, J (通讯作者)，Univ Lyon 1, Inserm U1290, Res Healthcare Performance RESHAPE, Lyon, France.
EM jamal.atfeh01@chu-lyon.fr
RI Huot, Laure/GLS-5988-2022; ATFEH, Jamal/PGU-1703-2026; /ABH-3323-2020;
   Guerre, Pascale/GXG-7161-2022
OI Huot, Laure/0000-0002-7870-9912; ATFEH, Jamal/0009-0007-9930-5582; 
FU Hospices Civils de Lyon; SmithNephew
FX The PICO-PTC study was sponsored by the Hospices Civils de Lyon and
   funded by a grant from Smith&Nephew (Investigator Initiated study
   grant). The funder had no role in the study design, data collection and
   analysis, decision to publish, or preparation of the manuscript. No
   authors received salary from the funder.
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NR 35
TC 0
Z9 0
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 18
PY 2025
VL 20
IS 4
AR e0322327
DI 10.1371/journal.pone.0322327
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2QF6O
UT WOS:001488708100006
PM 40299881
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Angulo, AR
   Caballero-Alvarado, J
   Sarmiento-Falen, J
   Zavaleta-Corvera, C
AF Angulo, Alexandra Rodriguez
   Caballero-Alvarado, Jose
   Sarmiento-Falen, Joaquin
   Zavaleta-Corvera, Carlos
TI Comparative Assessment of Negative Pressure Wound Therapy Versus
   Standard Treatment in Diabetic Foot Ulcers A Systematic Review and
   Meta-Analysis
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Conventional therapy; Diabetic foot ulcer; Effectiveness; Mellitus
   diabetes; Meta-analysis; Negative pressure wound therapy
ID VACUUM SEALING DRAINAGE
AB PURPOSE: The purpose of this systematic and metanalysis was to compare wound healing-related outcomes of negative pressure wound therapy (NPWT) to conventional therapy outcomes (time to granulation tissue formulation, ulcer depth, adverse effects amputation, pain, infection, and bleeding, along with hospital length of stay) for treatment of diabetic foot ulcers (DFU) in adults. METHODS: Systematic review and meta-analysis of pooled data. SEARCH STRATEGY:The electronic databases PubMed, Scopus, Web of Science, and Embase were searched. An artificial intelligence powered (Rayyan), proprietary software was used to retrieve, remove duplicates, and cite studies identified in our search. Two researchers and a conflict referee screened the studies in 2 phases; a title/abstract review, followed by reading all articles in full before identifying 12 studies included in this systematic review and metanalysis. RESULTS: Twelve studies were included in our metanalysis; 8 were clinical trials and 4 were observational studies. The pooled sample in the 8 clinical trials comprised 760 participants; 373 were managed with NPWT and 387 were managed with conventional therapy. No significant difference was observed for ulcer depth (P = .16). However, significant differences were found in mean difference in time to granulation tissue formation (P = .03), rate of amputation, pain (P = .01), infection rates (P = .005), and hospital length of stay (P < .001). The pooled sample evaluated in the 4 observational studies was 222; 100 were managed with NPWT and 122 with CT. Significant differences were found in time to granulation tissue formation (P < .001), amputation rates (P = .04), infection rate (P = .04), and hospital length of stay (P < .001). CONCLUSIONS: NPWT improves time to granulation tissue formation, reduces hospital stay, and the risk of secondary amputations, infections, and pain. Based on these findings we recommend incorporating NPWT as a standard component of DFU management.
C1 [Angulo, Alexandra Rodriguez; Caballero-Alvarado, Jose; Sarmiento-Falen, Joaquin; Zavaleta-Corvera, Carlos] Antenor Orrego Private Univ, Sch Med, Amer Sur Av 3145, Trujillo 13007, Peru.
C3 Universidad Privada Antenor Orrego
RP Zavaleta-Corvera, C (通讯作者)，Antenor Orrego Private Univ, Sch Med, Amer Sur Av 3145, Trujillo 13007, Peru.
EM aleroan96@gmail.com; jcaballeroalvarado@icloud.com;
   joaquinsarmiento1998@gmail.com; czavaletac3@upao.edu.pe
RI ; Zavaleta Corvera, Carlos/HPD-7962-2023
OI Caballero-Alvarado, Jose Antonio/0000-0001-8297-6901; Sarmiento,
   Joaquin/0009-0003-1309-2573; Zavaleta Corvera,
   Carlos/0000-0001-5918-8261
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NR 29
TC 3
Z9 3
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2025
VL 52
IS 3
BP 227
EP 238
DI 10.1097/WON.0000000000001164
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 2RP8G
UT WOS:001489651800002
PM 40377467
DA 2026-07-24
ER
PT J
AU Junak, M
   Gibson, A
AF Junak, Mary
   Gibson, Angela
TI Burn Progression in Human Skin-A Review of Current Knowledge and
   Opportunities for Future Research
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Review
DE burn progression; wound conversion; burn depth; indeterminate depth burn
ID TRANSIENT ISCHEMIC ATTACK; MAGNETIC-RESONANCE; WOUND PROGRESSION;
   IMAGING TECHNOLOGIES; APOPTOTIC DEATH; DEPTH; SECONDARY; INJURY; TISSUE;
   MODEL
AB Treatment of a burn wound often depends on the vertical depth of injury, which is commonly determined by visual assessment. Burn progression is the concept that in the early postburn period, a partial thickness burn may progress to a deeper burn requiring surgery. Therefore, the initial appearance of the wound may not be indicative of the eventual extent of injury. Several preclinical studies attribute burn wound progression to events such as vasoconstriction, inflammation, programmed cell death, free radical damage, and microvascular occlusion. Due to the concern for translatability of animal models for burn wounds, human studies are essential to understand burn progression in patients. Unfortunately, only a few small human studies exploring mechanisms, including apoptosis, ischemia, and infection exist. Inherent to determining burn progression is burn depth determination and healing potential, an area of research that has many ongoing investigations without a clear standard method to replace visual evaluation. Treatments to prevent burn progression in humans, including the use of negative pressure wound therapy and application of cooling dressings, have been studied with small sample sizes. Here, we aim to summarize the current data on human burn progression. Additionally, we discuss novel methods that could be used in future research to define early burn wound progression. Future work in human tissue should focus on the assessment and timeline of progression, explore the reversibility and prevention of injury progression, and use animal models in parallel as complementary tools for hypothesis-driven research based on findings in humans.
C1 [Junak, Mary; Gibson, Angela] Univ Wisconsin, Dept Surg, Madison, WI 53706 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Gibson, A (通讯作者)，Univ Wisconsin, Dept Surg, Madison, WI 53706 USA.
EM gibson@surgery.wisc.edu
RI ; Gibson, Angela/ABB-4367-2021
OI , Mary Junak/0009-0006-3761-3814; 
FU NIGMS NIH HHS [R01 GM145723] Funding Source: Medline
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NR 61
TC 3
Z9 3
U1 3
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2025
VL 46
IS 4
BP 758
EP 767
DI 10.1093/jbcr/iraf014
EA MAY 2025
PG 10
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 6YY7X
UT WOS:001489716500001
PM 39957288
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Gritsiuta, AI
   Reep, G
   Parupudi, S
   Petrov, RV
AF Gritsiuta, Andrei I.
   Reep, Gabriel
   Parupudi, Sreeram
   Petrov, Roman V.
TI Optimizing the management of anastomotic leaks after esophagectomy: a
   narrative review of salvage strategies and outcomes
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Review
DE Anastomotic leak; Esophageal cancer; Esophagectomy; Self-expanding metal
   stents; Vacuum-assisted closure
ID GASTROINTESTINAL PERFORATIONS; ENDOSPONGE THERAPY; SURGICAL-TREATMENT;
   STENT MIGRATION; COMPLICATIONS; EFFICACY; SURGERY; CLOSURE;
   PHARYNGOSTOMY; RESECTION
AB Background: Anastomotic leaks (ALs) after esophagectomy remain a major postoperative complication, leading to increased morbidity, prolonged hospital stays, and higher mortality. Despite advancements in surgical techniques and perioperative care, AL management lacks standardized protocols. This review aimed to evaluate current salvage strategies, including conservative, endoscopic, and surgical approaches, to optimize outcomes and reduce complications. Methods: A comprehensive literature search was conducted using PubMed, Scopus, Cochrane Library, and Google Scholar databases to identify studies published between 2000 and 2025 on AL management after esophagectomy. Peer-reviewed clinical trials, guidelines, and expert consensus reports were reviewed, focusing on minimally invasive and surgical interventions, patient outcomes, and emerging treatment strategies. Results: AL management strategies were classified into 3 primary approaches. Conservative management includes nutritional support, antibiotic therapy, and percutaneous drainage, particularly for contained leaks. Endoscopic interventions, such as self-expanding metal stents and endoscopic vacuum-assisted closure, have shown high success rates, with vacuum-assisted closure achieving superior closure outcomes. Hybrid techniques, including stent-over-sponge and vacuum-assisted closure-stent, are emerging as promising alternatives. Surgical interventions remain the gold standard for severe or refractory leaks with options, including primary repair, esophageal diversion, and delayed conduit reconstruction. Conclusion: A multidisciplinary approach is crucial for optimizing AL management, incorporating enhanced recovery protocols, early risk assessment, and individualized treatment plans. Endoscopic techniques have reduced the need for surgical revisions, but surgical intervention remains necessary for severe cases. Future research should focus on refining treatment algorithms, integrating novel technologies, and establishing standardized guidelines to improve patient survival and quality of life. (c) 2025 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Gritsiuta, Andrei I.; Petrov, Roman V.] Univ Texas Med Branch, Dept Surg, Div Cardiovasc & Thorac Surg, Galveston, TX 77555 USA.
   [Reep, Gabriel; Parupudi, Sreeram] Univ Texas Med Branch, Dept Internal Med, Div Gastroenterol & Hepatol, Galveston, TX USA.
C3 University of Texas System; University of Texas Medical Branch
   Galveston; University of Texas System; University of Texas Medical
   Branch Galveston
RP Gritsiuta, AI (通讯作者)，Univ Texas Med Branch, Dept Surg, Div Cardiovasc & Thorac Surg, Galveston, TX 77555 USA.
EM gritsiutaai@upmc.edu
RI Petrov, Roman/GXV-4075-2022; Gritsiuta, Andrei/ACD-4576-2022
OI Gritsiuta, Andrei/0000-0003-2265-9992
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NR 87
TC 2
Z9 2
U1 2
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD JUL
PY 2025
VL 29
IS 7
AR 102069
DI 10.1016/j.gassur.2025.102069
EA JAN 2025
PG 12
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 2ST5D
UT WOS:001490432300001
PM 40280464
OA hybrid
DA 2026-07-24
ER
PT J
AU Janssen, AH
   Wegdam, JA
   Jaspar, A
   Reilingh, TSD
   Vermeulen, H
   Eskes, AM
AF Janssen, Alexandra H. J.
   Wegdam, Johannes A.
   Jaspar, Alita
   Reilingh, Tammo S. de Vries
   Vermeulen, Hester
   Eskes, Anne M.
TI Patient preference with regard to negative pressure wound therapy and
   participation in wound care: a qualitative study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; patient participation; patient
   preference; quality of life; shared decision-making; wound; wound care;
   wound dressing; wound healing
ID OF-LIFE; DECISION-MAKING; CENTERED CARE; ULCERS; WANT
AB Objective: To explore the experiences and preferences of patients with wounds treated with negative pressure wound therapy (NPWT) regarding shared decision-making and patient participation. Method: Semi-structured interviews were conducted with adult patients treated with NPWT. Interview topics included shared decision-making and patients' active participation in wound treatment. Thematic analysis was applied to identify themes. Results: The interview cohort comprised ten patients. Four themes emerged: (1) Having a wound makes patients uncertain and thus influences their quality of life; (2) NPWT influences patients' daily lives; (3) Patients consider professional treatment decisions most important in the decision-making processes; (4) Self-management of wounds is accepted by patients only for low-complexity and wellhealing wounds under supervision. Participants emphasised their worries about the future and the impact of the wound/treatment on their families. After being thoroughly informed, participants preferred that health professionals decide on the treatment choice. In addition, participants and/or their relatives did not want to actively participate in complex wound care. As well as expressing a need for qualified wound care professionals, participants reported that they did not want to be or feel responsible for the wound treatment. Conclusion: Shared decision-making and active patient participation are underused and underexposed topics in wound care. Patients' recognition of the importance of their personal preferences can facilitate shared decision-making.
C1 [Janssen, Alexandra H. J.; Wegdam, Johannes A.; Reilingh, Tammo S. de Vries] Elkerliek Hosp, Dept Surg, Helmond, Netherlands.
   [Jaspar, Alita] Meander Grp, Home Care Nursing Homes & Residential Care, Landgraaf, Netherlands.
   [Vermeulen, Hester] Radboud Univ Nijmegen, Sci Inst Qual Healthcare, Nijmegen, Netherlands.
   [Vermeulen, Hester] HAN Univ Appl Sci, Inst Nursing, Fac Hlth & Social Studies, Nijmegen, Netherlands.
   [Eskes, Anne M.] Univ Amsterdam, Dept Surg, Amsterdam Gastroenterol Endocrinol Metab & Amsterd, Amsterdam UMC, Amsterdam, Netherlands.
   [Eskes, Anne M.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia.
   [Eskes, Anne M.] Griffith Univ, Sch Nursing & Midwifery, Gold Coast, Australia.
C3 Radboud University Nijmegen; University of Amsterdam; Menzies Health
   Institute Queensland; Griffith University; Griffith University
RP Janssen, AH (通讯作者)，Elkerliek Hosp, Dept Surg, Helmond, Netherlands.
EM sjanssen@elkerliek.nl
RI Eskes, Anne/HKV-3276-2023; Vermeulen, Hester/P-5739-2016
OI Janssen, Alexana/0000-0003-1816-0814
CR Amberscript, 2022, Fast and accurate transcripts, ready-made for you
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NR 55
TC 1
Z9 1
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2025
VL 34
IS 5
BP 340
EP 349
DI 10.12968/jowc.2022.0145
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 2TA8B
UT WOS:001490625500002
PM 40358217
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Levit, T
   Olaiya, O
   Lavoie, DCT
   Avram, R
   Coroneos, CJ
AF Levit, Tal
   Olaiya, Oluwatobi
   Lavoie, Declan C. T.
   Avram, Ronen
   Coroneos, Christopher J.
TI The Use of Negative Pressure Wound Therapy for Breast Surgeries: A
   Systematic Review and Meta-Analysis
SO PLASTIC SURGERY
LA English
DT Review
DE negative-Pressure wound therapy; vacuum-Assisted closure;
   negative-Pressure dressings; breast; traitement par pression n &
   eacute;gative; traitement des plaies; fermeture assist & eacute;e par le
   vide; pansements sous pression n & eacute;gative; sein
ID ABDOMINAL DONOR-SITE; FLAP NECROSIS; COMPLICATIONS; PREVENTION;
   MANAGEMENT
AB Background: Negative pressure wound therapy (NPWT) following breast surgery has emerged as a promising intervention theorized to reduce complication rates, improve patient-important outcomes, and enhance cost-effectiveness. This systematic review and meta-analysis aims to determine outcomes of NPWT following breast surgery. Methods: MEDLINE, Embase, CINAHL, Web of Science, and CENTRAL were searched to include all English-language, peer-reviewed observational and randomized controlled trials (RCTs) investigating NPWT on the breast or donor site among patients undergoing breast surgery. Studies evaluated at least one of the following outcomes: wound dehiscence, surgical site infection (SSI), implant loss, re-operation, re-admission, hematoma, seroma, and skin/wound necrosis. Quality of evidence was assessed with GRADE methodology. Results: This review includes 31 studies (eight RCTs, 23 observational) analyzing 3320 patients (4326 breasts). High certainty of evidence indicates decreased risk of wound dehiscence among NPWT patients in RCTs for all NPWT application sites (donor: 0.40; 95%CI 0.21, 0.79; breast: 0.59; 95%CI 0.41, 0.84) and observational trials where NPWT was placed on donor sites (0.64; 95%CI 0.42, 0.98). Some evidence indicates NPWT may reduce SSI, hematoma, seroma, and skin/wound necrosis incidence, however results are uncertain and varied in statistical significance. No effect was identified on rates of breast implant loss, re-operation, and re-admission, although this certainty of evidence is very low. Conclusions: Our findings suggest NPWT following breast surgery reduces the risk of wound dehiscence, may have some effect on SSIs, hematoma, seroma, and skin/wound necrosis; and does not demonstrate an effect on rates of implant loss, re-operation or re-admission.
C1 [Levit, Tal; Lavoie, Declan C. T.] McMaster Univ, Michael G DeGroote Sch Med, Hamilton, ON, Canada.
   [Levit, Tal; Olaiya, Oluwatobi; Avram, Ronen; Coroneos, Christopher J.] McMaster Univ, Dept Surg, Div Plast Surg, Hamilton, ON, Canada.
   [Coroneos, Christopher J.] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada.
C3 McMaster University; McMaster University; McMaster University
RP Coroneos, CJ (通讯作者)，McMaster Univ, Juravinski Hosp & Canc Ctr, Dept Surg, Div Plast Surg, 711 Concess St, Hamilton, ON L8V 1C3, Canada.; Coroneos, CJ (通讯作者)，McMaster Univ, Juravinski Hosp & Canc Ctr, Dept Hlth Res Methods Evidence & Impact, 711 Concess St, Hamilton, ON L8V 1C3, Canada.
EM coronec@mcmaster.ca
RI Coroneos, Christopher/AAQ-2460-2021; Levit, Tal/MTD-1593-2025
OI Olaiya, Oluwatobi R/0000-0001-6632-9595; Levit, Tal/0000-0003-3196-4411
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NR 60
TC 4
Z9 4
U1 1
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2292-5503
EI 2292-5511
J9 PLAST SURG-CHIR PLAS
JI Plast. Surg.
PD MAY
PY 2026
VL 34
IS 2
BP 185
EP 200
DI 10.1177/22925503251336253
EA MAY 2026
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GM4FJ
UT WOS:001491077200001
PM 40443408
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Chen, QY
   Li, B
   Pan, L
AF Chen, Qin-Ying
   Li, Bei
   Pan, Li
TI Postoperative Anastomotic Leakage Complicated with Severe
   Intra-abdominal Infection and Peristomal Abscess after Colon Cancer
   Surgery: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE anastomotic leak; colorectal cancer; intra-abdominal infection;
   negative-pressure wound therapy; negative-pressure wound therapy with
   instillation and dwell time; peristomal abscess
ID INCONTINENCE-ASSOCIATED DERMATITIS; ETIOLOGY
AB Postoperative anastomotic leakage following surgery for colorectal cancer is a serious complication that is frequently associated with significant intra-abdominal infection and the formation of peristomal abscesses. Patients with this condition often present with complex medical comorbidities and face considerable challenges in achieving wound healing. In this case report, a 57-year-old man presented with colonic obstruction secondary to colon cancer and subsequently underwent curative surgery. Postoperatively, anastomotic leakage occurred, which necessitated resection of the anastomosis and the formation of a descending colostomy. The patient subsequently developed severe intra-abdominal infection and peristomal abscess, leading to impaired wound healing. Clinicians implemented a treatment regimen combining continuous negative-pressure wound therapy (NPWT) with intermittent NPWT with instillation and dwell time. This approach resulted in rapid wound healing. Ultimately, the patient successfully underwent colostomy closure, restoring gastrointestinal continuity. For abdominal wounds with severe fecal contamination and extensive separation of the dermis and subcutaneous tissues, the combination of continuous NPWT and intermittent NPWT with instillation and dwell time may be an efficacious therapeutic strategy.
C1 [Chen, Qin-Ying; Li, Bei; Pan, Li] Peking Univ, Dept Gastrointestinal Surg, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China.
   [Chen, Qin-Ying] Peking Univ, Head Wound & Ostomy Care Clin, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China.
C3 Peking University; Peking University
RP Chen, QY (通讯作者)，Peking Univ, Dept Gastrointestinal Surg, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China.; Chen, QY (通讯作者)，Peking Univ, Head Wound & Ostomy Care Clin, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China.
EM coralcqy@163.com; 21658366@qq.com; lipanmedicine@163.com
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NR 18
TC 1
Z9 2
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUN
PY 2025
VL 38
IS 5
BP 274
EP 277
DI 10.1097/ASW.0000000000000286
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 2UM0H
UT WOS:001491600900008
PM 40117503
DA 2026-07-24
ER
PT J
AU Su, HY
   Chew, KY
   Graves, N
   Ou, HT
AF Su, Hsuan-Yu
   Chew, Khong-Yik
   Graves, Nicholas
   Ou, Huang-Tz
TI Cost-effectiveness of ON101 with general wound care for diabetic foot
   ulcers among patients with type 2 diabetes in Singapore: Analysis of a
   multi-ethnic country in Asia
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE diabetic foot ulcer; economic evaluation; incremental cost-effectiveness
   ratio; negative pressure wound therapy; wound healing
ID BURDEN
AB Aims Diabetic foot ulcers (DFUs) impose a vast health and economic burden on individuals and healthcare systems globally. We assessed the cost-effectiveness of adding ON101, a novel treatment for accelerating wound healing, to general wound care (GWC) versus GWC alone for DFUs in Singapore, a multi-ethnic country with increasing DFU prevalence in a growing type 2 diabetes population. Materials and MethodsA Markov model was utilized to estimate the healthcare costs and quality-adjusted life years (QALYs) over 5 years from a healthcare sector perspective. Model inputs were mainly derived from the Singapore Wound Registry and published literature. The primary outcome was the incremental cost-effectiveness ratio (ICER). Subgroup analyses stratified by clinically important DFU conditions and scenario analyses were conducted to confirm the study's robustness. Results Compared to GWC alone, adding ON101 yielded greater QALY gained (i.e., 0.15) and lower healthcare costs (i.e., -US$16237) for patients with DFUs. Remarkable cost-savings from the use of ON101 with GWC were observed for patients with complex DFUs, namely ICERs of -US$161 963, -US$181 726 and -US$199 130 per QALY gained for cases with HbA1c >= 9%, ulcer duration >6 months and ulcer size >5 cm(2), respectively. Scenario analysis comparing ON101 with GWC to negative pressure wound therapy with GWC yielded an ICER of -US$677 243 per QALY gained. Conclusions Combining ON101 with GWC versus GWC alone was highly cost-effective for DFUs in Singapore. Also, the economic results for complex DFU cases underscore the value of ON101 in addressing DFU treatment challenges for managing complex cases, offering cost-savings alongside clinical benefits.
C1 [Su, Hsuan-Yu; Ou, Huang-Tz] Natl Cheng Kung Univ, Inst Clin Pharm & Pharmaceut Sci, Coll Med, Univ Rd, Tainan 701, Taiwan.
   [Chew, Khong-Yik] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore, Singapore.
   [Graves, Nicholas] Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore, Singapore.
   [Ou, Huang-Tz] Natl Cheng Kung Univ, Coll Med, Dept Pharm, Tainan, Taiwan.
C3 National Cheng Kung University; Singapore General Hospital; National
   University of Singapore; National Cheng Kung University
RP Ou, HT (通讯作者)，Natl Cheng Kung Univ, Inst Clin Pharm & Pharmaceut Sci, Coll Med, Univ Rd, Tainan 701, Taiwan.; Chew, KY (通讯作者)，Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
EM chew.khong.yik@singhealth.com.sg; huangtz@mail.ncku.edu.tw
RI Ou, Huang-Tz/AGO-0498-2022
FU Ministry of Science and Technology, Taiwan [MOST
   112-2628-B-006-008-MY3]; Ministry of Science and Technology in Taiwan
FX The authors acknowledge funding from the Ministry of Science and
   Technology in Taiwan (grant MOST 112-2628-B-006-008-MY3) (Huang-Tz Ou).
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NR 32
TC 3
Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD AUG
PY 2025
VL 27
IS 8
BP 4344
EP 4353
DI 10.1111/dom.16473
EA MAY 2025
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4PI4S
UT WOS:001491975400001
PM 40396474
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Chen, SJ
   Ji, N
   Chen, YX
   Xiao, JR
   Wei, XZ
   Liu, YK
AF Chen, Shu-Jun
   Ji, Ning
   Chen, Yu-Xuan
   Xiao, Jian-Rui
   Wei, Xiao-Zong
   Liu, Yan-Kun
TI Effectiveness of negative pressure wound therapy in Ludwig's angina: a
   retrospective study of 18 cases
SO BMC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Ludwig's angina; Necrotizing soft
   tissue infection; Necrotizing fasciitis
ID CERVICAL NECROTIZING FASCIITIS; VACUUM-ASSISTED CLOSURE; MANAGEMENT;
   HEAD
AB Objective To investigate the effectiveness of negative pressure wound therapy (NPWT) for Ludwig's angina (LA). Methods We retrospectively reviewed 18 patients with LA admitted to the 82nd Group Army Hospital of PLA between October 2014 and October 2021. All patients underwent surgical drainage and debridement within 6 h after admission. A minimally invasive approach involving bilateral small incisions in the submandibular area was used to perform the procedure. An NPWT device was applied for positive drainage of the involved spaces after debridement. Postoperatively, the patients received the appropriate supportive care and antibiotic therapy. Data collection encompassed sex, age, systemic diseases, dressing change frequency, NPWT duration, wound healing time, and ICU stay length. Follow-up was performed to evaluate recurrence, scarring, and neck mobility. For comparative analysis, control data were obtained from LA patients treated with conventional surgical drainage between January 2008 and September 2014. Descriptive statistics and Student's t-test were employed for statistical analysis. Results In the NPWT group, all patients had uneventful courses during hospitalization and were discharged upon complete wound healing. Fifteen patients required only a single session of surgical debridement with NPWT, while the remaining three underwent two procedures. Upon NPWT device removal, all infectious cavities exhibited clean wounds with mature granulation tissue formation. Compared to the conventional surgery group, the NPWT group demonstrated a significantly shorter wound healing time (15.33 +/- 3.93 vs. 19.50 +/- 2.17 days; p = 0.025), reduced ICU stay duration (0.61 +/- 0.61 vs. 2.17 +/- 0.75 days; p < 0.001) and markedly fewer dressing changes (2.17 +/- 0.38 vs. 17.00 +/- 3.16; p < 0.001). Conclusions NPWT demonstrated excellent effectiveness in the management of LA. Compared to conventional surgical debridement and drainage, it offers several distinct clinical advantages, including accelerated wound healing, shortened ICU stays, and reduced dressing change frequency. These benefits are clinically linked to both reduced postoperative pain perception and decreased nursing workload. Additionally, smaller incisions result in less surgical trauma and improved cosmetic outcomes. NPWT should be considered as a viable approach in the management of LA. Future randomized controlled trials are needed to confirm NPWT's superiority in larger cohorts.
C1 [Chen, Shu-Jun; Chen, Yu-Xuan; Xiao, Jian-Rui; Wei, Xiao-Zong; Liu, Yan-Kun] 82nd Grp Army Hosp PLA, Dept Stomatol, 991 Baihuadong Rd, Baoding 071000, Peoples R China.
   [Ji, Ning] 82nd Grp Army Hosp PLA, Qual Management Dept, 991 Baihuadong Rd, Baoding 071000, Peoples R China.
RP Chen, SJ (通讯作者)，82nd Grp Army Hosp PLA, Dept Stomatol, 991 Baihuadong Rd, Baoding 071000, Peoples R China.
EM shujunchen001@163.com
RI Ji, Ning/PJS-8848-2026; Liu, Yankun/ORJ-7187-2025
FU Medical Science Foundation of the PLA Central Theater Command Army [:,
   2023LC05]
FX This work is supported by the Medical Science Foundation of the PLA
   Central Theater Command Army (grant:No. 2023LC05).
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NR 25
TC 0
Z9 0
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD MAY 22
PY 2025
VL 25
IS 1
AR 223
DI 10.1186/s12893-025-02957-y
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2WB8A
UT WOS:001492697500002
PM 40399898
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rajabaleyan, P
   Cuk, P
   Möller, S
   Qvist, N
   Ellebaek, MB
AF Rajabaleyan, Pooya
   Cuk, Pedja
   Moller, Soren
   Qvist, Niels
   Ellebaek, Mark Bremholm
TI Vacuum-assisted closure or primary closure with relaparotomy on-demand
   in patients with secondary peritonitis: a systematic review and
   meta-analysis
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Secondary peritonitis; Vacuum-assisted abdominal closure; Open abdomen
ID PRESSURE WOUND THERAPY; TEMPORARY ABDOMINAL CLOSURE; TOPICAL
   NEGATIVE-PRESSURE; OPEN ABDOMEN TREATMENT; PLANNED RELAPAROTOMY;
   INTRAABDOMINAL SEPSIS; FASCIAL CLOSURE; SEPTIC PATIENTS; LAPAROSTOMY;
   MANAGEMENT
AB Background Secondary peritonitis is a serious condition with significant morbidity and mortality. Its management requires emergency laparotomy for source control. Vacuum-assisted closure (VAC) and primary abdominal closure (PAC) are the main strategies for managing the laparostomy after source control. Despite the increasing use of VAC, concerns persist regarding its complications and long-term outcomes compared with PAC. Methods This systematic review followed PRISMA 2020 and MOOSE. The Cochrane Risk of Bias (RoB 2) tool, MINORS and GRADE framework assessed study quality and evidence certainty. The protocol was registered in PROSPERO (CRD42022304724). A comprehensive search of MEDLINE, Embase, and the Cochrane Library from January 2004 to August 2024 identified studies reporting postoperative outcomes following VAC or PAC after laparotomy for secondary peritonitis. The included studies had to report at least two key outcomes: mortality, postoperative complications, incisional hernia, secondary fascial closure, and hospital or intensive care unit (ICU) length of stay. Results Thirty-three studies including 4,520 patients were analyzed. Mortality was 31.1% in VAC and 22.2% in PAC (p = 0.327). Postoperative complications were higher with VAC (71.0% vs. 39.3%, p = 0.001). Incisional hernia rates were similar (21.3% vs. 20.8%, p = 0.958). Secondary fascial closure rate was significantly lower with VAC (58.1% vs. 85.9%, p < 0.001). VAC patients had longer ICU stays (21.1 vs. 9.7 days, p = 0.04), while hospital stay did not differ. Most studies had a high risk of bias, and GRADE assessment showed low to very low evidence certainty. Conclusion VAC therapy was associated with more postoperative complications, a lower fascial closure rate, and a longer ICU length of stay compared with PAC. Thirty-day mortality rates did not differ between the approaches. However, most of studies included were subject to serious risk of bias and a low level of certainty in evidence.
C1 [Rajabaleyan, Pooya; Cuk, Pedja; Qvist, Niels; Ellebaek, Mark Bremholm] Odense Univ Hosp, Res Unit Surg, Odense, Denmark.
   [Rajabaleyan, Pooya; Cuk, Pedja; Qvist, Niels; Ellebaek, Mark Bremholm] Univ Southern Denmark, Odense, Denmark.
   [Moller, Soren] Odense Univ Hosp, Open Patient Data Explorat Network OPEN, Odense, Denmark.
   [Rajabaleyan, Pooya; Cuk, Pedja; Qvist, Niels; Ellebaek, Mark Bremholm] Univ Southern Denmark, Dept Clin Res, DK-5000 Odense C, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; University of Southern Denmark; Odense University
   Hospital; University of Southern Denmark
RP Rajabaleyan, P (通讯作者)，Odense Univ Hosp, Res Unit Surg, Odense, Denmark.; Rajabaleyan, P (通讯作者)，Univ Southern Denmark, Odense, Denmark.; Rajabaleyan, P (通讯作者)，Univ Southern Denmark, Dept Clin Res, DK-5000 Odense C, Denmark.
EM Pooya.Rajabaleyan@skane.se; Pedja.Cuk@rsyd.dk; Soren.Moller@rsyd.dk;
   famqvist@dadlnet.dk; Mark.Ellebaek1@rsyd.dk
RI ; Möller, Sören/X-8738-2019
OI Cuk, Pedja/0000-0003-0582-604X; Möller, Sören/0000-0003-0858-4269;
   Ellebaek, Mark Bremholm/0000-0001-6550-7505; Rajabaleyan,
   Pooya/0000-0002-6882-9427
FU Novo Nordisk Fonden [NNF19OC0058637] Funding Source: Medline
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NR 68
TC 1
Z9 3
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD MAY 22
PY 2025
VL 20
IS 1
AR 42
DI 10.1186/s13017-025-00615-5
PG 21
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 2WB9U
UT WOS:001492702100001
PM 40399929
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sun, HJ
   Si, SW
   Ma, YM
   Liu, XK
   Geng, HF
   Liang, J
AF Sun, Hao-Jie
   Si, Shan-Wen
   Ma, Ya-Mei
   Liu, Xue-Kui
   Geng, Hou-Fa
   Liang, Jun
TI Role of nuclear factor erythroid 2-related factor 2 in negative pressure
   wound therapy for diabetic foot ulcers
SO WORLD JOURNAL OF DIABETES
LA English
DT Article
DE Negative pressure wound therapy; Diabetic foot ulcers; Nuclear factor
   erythroid 2-related factor 2; Kelch-like epichlorohydrin-associated
   protein 1; Healing
ID NRF2; ANGIOGENESIS; NPWT
AB BACKGROUND Negative pressure wound therapy (NPWT) is a potential treatment for diabetic foot ulcers (DFUs), although the mechanisms underlying its effectiveness remain unclear. This study posits that NPWT may improve wound healing by promoting angiogenesis and activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like epichlorohydrin-associated protein 1 (Keap1) signaling pathway, which is crucial for the body's defense against oxidative stress. The hypothesis indicates that enhancing antioxidant defenses through NPWT may positively affect the healing process. There are still limited data on the roles of Nrf2, its downstream signaling molecules, and angiogenesis markers in patients undergoing NPWT. AIM To study the mechanism of NPWT in DFUs. METHODS This study included a total of 40 hospitalized patients with DFUs from Xuzhou Central Hospital, who were divided into Control group (n = 21) and NPWT group (n = 19). The levels of Nrf2 and Keap1 were analyzed in the granulation tissue 7 days after treatment. The wound condition, erythrocyte sedimentation rate (ESR), procalcitonin (PCT), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), cluster of differentiation 31 (CD31), and levels of oxidative stress [malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (T-AOC)] were analyzed before and 7 days after treatment by the Mann-Whitney U test. RESULTS The NPWT group demonstrated significant improvements in wound healing compared to the control group after 7 days of treatment. The levels of ESR, PCT, IL-6, and TNF-alpha were significantly reduced in the NPWT group compared to the control group (P < 0.05), while the levels of CD31, VEGF, and b-FGF showed significant increases (P < 0.05). The NPWT group exhibited notable elevations in the levels of Nrf2 and its downstream targets (SOD, CAT, and T-AOC), accompanied by decreases in the levels of Keap1 and MDA (P < 0.05). CONCLUSION NPWT may contribute to the healing of DFUs by potentially reducing levels of oxidative stress. Its effects could possibly be enhanced through the action of Nrf2.
C1 [Sun, Hao-Jie; Liu, Xue-Kui; Geng, Hou-Fa; Liang, Jun] Xuzhou Cent Hosp, Dept Endocrinol, 199 Jiefang South Rd, Xuzhou 221009, Jiangsu, Peoples R China.
   [Si, Shan-Wen] Anhui Med Univ, Fuyang Hosp, Dept Sci Res, Fuyang 236112, Anhui, Peoples R China.
   [Ma, Ya-Mei] Anhui Med Univ, Fuyang Hosp, Electrocardiogram Room, Fuyang 236112, Anhui, Peoples R China.
C3 Southeast University - China; Anhui Medical University; Anhui Medical
   University
RP Liang, J (通讯作者)，Xuzhou Cent Hosp, Dept Endocrinol, 199 Jiefang South Rd, Xuzhou 221009, Jiangsu, Peoples R China.
EM mwlj521@njmu.edu.cn
RI Sun, Haojie/LRT-6797-2024; Houfa, Geng/ABI-6352-2020
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NR 35
TC 0
Z9 0
U1 1
U2 4
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD MAY 15
PY 2025
VL 16
IS 5
AR 104350
DI 10.4239/wjd.v16.i5.104350
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2WQ5R
UT WOS:001493085500012
PM 40487630
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Reese, MW
   Hogge, RL
   Roess, BJ
   Hepner, JM
   Luke, RD
   Rendel, RE
   Kabir, IK
   Nguyen, TM
   Snyder, KN
   Heaton, JA
   Martyak, MT
AF Reese, Miles W.
   Hogge, Raymond L.
   Roess, Brendan J.
   Hepner, John M.
   Luke, Robert D.
   Rendel, Ricardo E.
   Kabir, Ishraq K.
   Nguyen, Tuan M.
   Snyder, Kristen N.
   Heaton, Julia A.
   Martyak, Michael T.
TI The Implementation of Incisional Negative Pressure Therapy in Trauma
   Laparotomies Leads to Fewer Open Wounds at Discharge
SO AMERICAN SURGEON
LA English
DT Article
DE surgical infection; wound healing; trauma
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE
AB Background: Surgical site infections (SSIs) tend to be higher in emergent trauma cases. To combat this increased risk, the skin is often left open and allowed to heal by secondary intention. We sought to investigate the effect of the implementation of incisional negative pressure wound therapy (iNPWT) in trauma laparotomies. Methods: A single-institution retrospective chart review was performed of trauma patients receiving an emergent exploratory laparotomy between 2015 and 2022. Patients with class II and III wounds were included. The primary outcome was open wound at discharge between the pre-iNPWT and post-iNPWT implementation. The secondary outcome was development of superficial SSI in closed wounds. Results: 260 patients, 111 pre-iNPWT and 149 post-iNPWT implementation, were included. The proportion of patients who were discharged with an open wound in the pre-iNPWT group was 52.3% vs 18.8% in the post-iNPWT group, P = <.001. The proportion of patients with closed wounds who developed a superficial SSI in the pre-iNPWT group was 12.1%, 8 of 66, vs 5.9%, 8 of 135, in the post-iNPWT group, P = .13. The proportion of patients with closed class III wounds who developed a superficial SSI was 14.0%, 7 of 50, vs 5.0%, 6 of 119, in the post-iNPWT group, P = .046. Conclusion: Our study identified a decrease in the number of patients who were discharged with an open wound after the implementation of iNPWT without an increase in SSIs. A decrease in SSIs in class III wounds closed with iNPWT was also observed.
C1 [Reese, Miles W.; Hogge, Raymond L.; Roess, Brendan J.; Hepner, John M.; Luke, Robert D.; Rendel, Ricardo E.; Kabir, Ishraq K.; Nguyen, Tuan M.; Snyder, Kristen N.; Heaton, Julia A.; Martyak, Michael T.] Old Dominion Univ, Eastern Virginia Med Sch, Dept Surg, Macon & Joan Brock Virginia Hlth Sci, 825 Fairfax Ave 610, Norfolk, VA 23507 USA.
C3 Old Dominion University; Eastern Virginia Medical School
RP Reese, MW (通讯作者)，Old Dominion Univ, Eastern Virginia Med Sch, Dept Surg, Macon & Joan Brock Virginia Hlth Sci, 825 Fairfax Ave 610, Norfolk, VA 23507 USA.
EM reesemw@evms.edu
OI Hogge, Raymond/0000-0002-4176-9209
CR 3M Health Care, 2019, PREVENA INCISION MAN
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NR 18
TC 1
Z9 1
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JUL
PY 2025
VL 91
IS 7
BP 1123
EP 1128
DI 10.1177/00031348251339700
EA MAY 2025
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3TL4F
UT WOS:001494727100001
PM 40401823
DA 2026-07-24
ER
PT J
AU Duricová, J
   Brozmanová, H
   Jurica, J
   Kacírová, I
   Sistík, P
   Kanková, K
   Tomásková, H
   Kolek, M
AF Duricova, Jana
   Brozmanova, Hana
   Jurica, Jan
   Kacirova, Ivana
   Sistik, Pavel
   Kankova, Klara
   Tomaskova, Hana
   Kolek, Martin
TI Clindamycin, Ciprofloxacin, and Co-trimoxazole Wound Penetration in
   Open-Heart Surgery Patients Receiving Negative Pressure Wound Therapy
   for Deep Sternal Wound Infection: A Single-Center Prospective
   Observational Study
SO BRATISLAVA MEDICAL JOURNAL
LA English
DT Article
DE Ciprofloxacin; Clindamycin; Co-trimoxazole; Deep sternal wound
   infection; Negative pressure wound therapy; Wound penetration
ID VACUUM-ASSISTED CLOSURE; TISSUE PENETRATION; CARDIAC-SURGERY;
   RISK-FACTORS; PHARMACOKINETICS; MEDIASTINITIS; MICROBIOLOGY; MANAGEMENT;
   VANCOMYCIN; IMPACT
AB Background and Objective Achieving sufficient antibiotic concentration in the tissue is a key prerequisite for effective wound infection treatment. We evaluated clindamycin, ciprofloxacin, and co-trimoxazole penetration into exudate among patients treated with negative pressure wound therapy (NPWT). Methods Ten consecutive patients receiving NPWT for deep sternal wound infection (DSWI) after open-heart surgery were enrolled in this prospective observational study. Serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3, and 5 h after clindamycin administration, and at 0, 0.5, 1, 2, 3, and 6 h after ciprofloxacin and co-trimoxazole administration. Wound penetration was assessed as the ratio of the average antibiotic concentration in the wound exudate to that found in serum. Results The wound penetration ratio was significantly higher for free clindamycin concentrations (4.19 +/- 1.43) than for total clindamycin concentrations (0.83 +/- 0.23) (p = 0.007). Wound penetration was similar for both total and free ciprofloxacin concentrations (0.87 +/- 0.35 vs. 0.81 +/- 0.32; p = 0.777). The total and free exudate penetration ratios were about twofold higher for sulfamethoxazole (0.8 and 1.1, respectively) compared to trimethoprim (0.36 and 0.42, respectively). The hospital stay of open-heart surgery patients with DSWI was significantly longer (49 +/- 20 days) than in those without infection (14 +/- 12 days; p < 0.001). No 90-day mortality was observed. One patient experienced late DSWI recurrence. During the median follow-up of 2.3 years, all-cause mortality was 4.8%. Conclusion Clindamycin, ciprofloxacin, and co-trimoxazole effectively penetrated wound exudate in patients on NPWT for post-sternotomy DSWI.
C1 [Duricova, Jana; Brozmanova, Hana; Kacirova, Ivana; Sistik, Pavel] Univ Hosp Ostrava, Inst Lab Med, Dept Clin Pharmacol, Ostrava, Czech Republic.
   [Duricova, Jana; Brozmanova, Hana; Kacirova, Ivana; Sistik, Pavel] Univ Ostrava, Fac Med, Dept Clin Pharmacol, Ostrava, Czech Republic.
   [Jurica, Jan] Masaryk Univ, Fac Med, Fac Pharm, Dept Pharmacol,Dept Pharmacol & Toxicol, Brno, Czech Republic.
   [Jurica, Jan] Masaryk Mem Canc Inst, Hosp Pharm, Brno, Czech Republic.
   [Kankova, Klara; Kolek, Martin] Univ Hosp Ostrava, Dept Cardiac Surg, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.
   [Tomaskova, Hana] Univ Ostrava, Fac Med, Dept Epidemiol & Publ Hlth, Ostrava, Czech Republic.
   [Kolek, Martin] Univ Ostrava, Fac Med, Dept Clin Subjects, Ostrava, Czech Republic.
C3 University Hospital Ostrava; University of Ostrava; Masaryk University;
   Masaryk Memorial Cancer Institute; University Hospital Ostrava;
   University of Ostrava; University of Ostrava
RP Kolek, M (通讯作者)，Univ Hosp Ostrava, Dept Cardiac Surg, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.; Kolek, M (通讯作者)，Univ Ostrava, Fac Med, Dept Clin Subjects, Ostrava, Czech Republic.
EM martin.kolek@fno.cz
RI Jurica, Jan/T-2645-2017; Kacirova, Ivana/I-4241-2016; Tomaskova,
   Hana/JCE-4509-2023; Brozmanova, ./G-9793-2019; Kolek, Martin/D-4115-2018
OI Jurica, Jan/0000-0002-0257-6711; Kacirova, Ivana/0000-0001-6618-754X;
   Tomaskova, Hana/0000-0002-9608-1276; Kolek, Martin/0000-0002-0418-3006
FU Ministerstvo Zdravotnictv Cesk Republiky [FNOs/2021]; Ministry of
   Health, Czech Republic-conceptual development of research organization
   [CZ.10.03.01/00/22_003/0000003]; European Union; Faculty of Medicine,
   University of Ostrava
FX This study was supported by the Ministry of Health, Czech
   Republic-conceptual development of research organization (FNOs/2021).
   This article has been produced with the financial support of the
   European Union, under the LERCO project number
   CZ.10.03.01/00/22_003/0000003 via the Operational Programme Just
   Transition. The authors thank Professor Milan Grundmann (Department of
   Clinical Pharmacology, University Hospital Ostrava and Faculty of
   Medicine, University of Ostrava, Czech Republic) for his valuable expert
   advice and consultation.
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NR 35
TC 0
Z9 0
U1 3
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PD AUG
PY 2025
VL 126
IS 8
BP 1891
EP 1903
DI 10.1007/s44411-025-00194-6
EA MAY 2025
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5KW7W
UT WOS:001495243100001
OA gold
DA 2026-07-24
ER
PT J
AU Schröder, TA
   Karasavvas, A
   Bauckloh, M
   Schulz, MC
   Lauer, G
   Kroschwald, LM
AF Schroeder, Tom Alexander
   Karasavvas, Athanasios
   Bauckloh, Maximilian
   Schulz, Matthias C.
   Lauer, Guenter
   Kroschwald, Lysann Michaela
TI Influence of Unidirectional Vacuum Application on Bone Healing in
   Maxillofacial Surgery
SO CELLS
LA English
DT Article
DE VAC; NPWT; bone healing; regeneration; maxillofacial surgery
ID PRESSURE WOUND THERAPY; FIBROBLAST GROWTH FACTOR-2; ASSISTED CLOSURE;
   SOFT; DIFFERENTIATION; REGENERATION; MECHANISMS; INCREASES; PATHWAYS;
   INJURY
AB Negative-pressure wound therapy (NPWT) using vacuum-assisted closure (VAC) is a well known tissue defect bridging method that applies a vacuum pump to sterile, open-cell foam dressings via suction tubes. Although it has mostly been described for soft tissue use, there are also a few studies concerning its use on hard tissue. However, as oral and maxillofacial surgery has to deal with both soft and hard tissue, which lie next to each other in these regions, there is a particular need to assess the influence of negative pressure on bone. Therefore, the effects of different negative pressure levels (530 mbar and 725 mbar) and atmospheric pressure (1013 mbar) on bone tissue cultures and osteoblast cell cultures were investigated over periods of 1, 3, and 6 weeks. During the culture period, osteoblast growth and the tissue regeneration of bone defects were studied in vitro using tissue cultures that were histologically supplemented by cytological investigations and quantitative RNA expression studies. In the bone defect model, there was a faster defect reduction using NPWT; the effect was especially strong for 530 mbar. Compared to the control group, up to 30% more newly generated bone tissue was detected. This effect on the mineralization capacity was assessed by the mRNA expression of osteogenic marker genes, as well as the receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG), two multifaceted cytokines that regulate bone metabolism. The influence of negative pressure consequently resulted in a decreased RANKL/OPG ratio in osteoblasts. Associated with the upregulation of marker genes to up to 400%, including Col1, BMP4, OCN, and RUNX2, the decrease in the RANKL/OPG ratio to 41% indicates the stimulation of osteogenesis. Since VAC has been shown to be a safe and effective method to close wounds in general, these data suggest that patients suffering from compound bone and soft tissue defects in the maxillofacial area may benefit from an adapted therapy approach accelerating both soft and hard tissue regeneration.
C1 [Schroeder, Tom Alexander; Karasavvas, Athanasios; Bauckloh, Maximilian; Lauer, Guenter; Kroschwald, Lysann Michaela] Tech Univ Dresden, Fac Med Carl Gustav Carus, Dept Oral & Maxillofacial Surg, Fetscherstr 74, D-01307 Dresden, Germany.
   [Schulz, Matthias C.] Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Dept Oral & Maxillofacial Surg, Osianderstr 2-8, D-72076 Tubingen, Germany.
   [Kroschwald, Lysann Michaela] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Ctr Translat Bone Joint & Soft Tissue Res, Fetscherstr 74, D-01307 Dresden, Germany.
C3 Technische Universitat Dresden; Eberhard Karls University of Tubingen;
   Eberhard Karls University Hospital; Technische Universitat Dresden; Carl
   Gustav Carus University Hospital
RP Kroschwald, LM (通讯作者)，Tech Univ Dresden, Fac Med Carl Gustav Carus, Dept Oral & Maxillofacial Surg, Fetscherstr 74, D-01307 Dresden, Germany.; Kroschwald, LM (通讯作者)，Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Ctr Translat Bone Joint & Soft Tissue Res, Fetscherstr 74, D-01307 Dresden, Germany.
EM lysann.kroschwald@ukdd.de
RI ; Schröder, Tom Alexander/LXB-0402-2024
OI Kroschwald, Lysann Michaela/0000-0001-5381-9958; Schröder, Tom
   Alexander/0009-0001-9689-3020
FU Applicant program MeDDrive of the Medical Faculty Carl Gustav Carus of
   the TUD MedDriveGrant [60418]
FX This research was funded by the applicant program MeDDrive of the
   Medical Faculty Carl Gustav Carus of the TUD MedDriveGrant, grant number
   60418.
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NR 52
TC 0
Z9 0
U1 0
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAY 21
PY 2025
VL 14
IS 10
AR 751
DI 10.3390/cells14100751
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 3AH5N
UT WOS:001495570300001
PM 40422254
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Riza, SM
   Porosnicu, AL
   Sinescu, RD
AF Riza, Stefania-Mihaela
   Porosnicu, Andrei-Ludovic
   Sinescu, Ruxandra Diana
TI A Comprehensive Literature Review on the Therapeutic Potential of
   Platelet-Rich Plasma for Diabetic Foot Management: Insights from a Case
   of a Neglected Deep Plantar Abscess
SO HEALTHCARE
LA English
DT Review
DE chronic wounds; diabetic foot ulcers (DFUs); platelet-rich plasma (PRP);
   regenerative medicine; limb salvage surgery; growth factors;
   angiogenesis; re-epithelialization; wound healing; tissue regeneration;
   chronic wound management; advanced wound therapy
ID GROWTH-FACTORS; ULCERS; INFECTION; GEL; DIAGNOSIS; EXOSOMES; EFFICACY
AB Background: Diabetic foot ulcers (DFUs) remain a major complication of diabetes, characterized by impaired wound healing, high infection risk, and an increased likelihood of limb amputation. Platelet-rich plasma (PRP) has emerged as a promising adjunctive therapy due to its regenerative properties, promoting angiogenesis, modulating inflammation, and accelerating tissue repair. Methods: This literature review explores the current evidence regarding the use of PRP in the management of DFUs. It was conducted using the PubMed database to evaluate the efficacy of PRP in DFUs. The search was restricted to studies published in the last 10 years, including randomized controlled trials, meta-analyses, and systematic reviews. The inclusion criteria focused on studies assessing PRP as a standalone treatment or in combination with other wound care strategies, evaluating key clinical outcomes such as wound healing rates, infection control, tissue regeneration, and amputation prevention. Results: A total of 35 studies met the inclusion criteria, including 11 meta-analyses, 15 review articles, and 9 clinical trials. PRP demonstrated potential benefits in accelerating wound healing, reducing inflammation, and promoting granulation tissue formation. Additionally, PRP combined with negative-pressure wound therapy (NPWT) showed superior outcomes in reducing amputation rates. However, findings varied based on patient characteristics, PRP preparation techniques, and treatment protocols. Conclusions: PRP represents a valuable adjunct in DFU management, contributing to improved healing outcomes and reduced complications. However, the lack of standardized protocols and variability in clinical results highlight the need for further large-scale, multicenter studies to establish its definitive role in diabetic wound care.
C1 [Riza, Stefania-Mihaela; Porosnicu, Andrei-Ludovic; Sinescu, Ruxandra Diana] Carol Davila Univ Med & Pharm, Dept Plast Surg & Reconstruct Microsurg, Bucharest 050474, Romania.
   [Riza, Stefania-Mihaela; Porosnicu, Andrei-Ludovic; Sinescu, Ruxandra Diana] Elias Emergency Univ Hosp, Dept Plast Surg & Reconstruct Microsurg, Bucharest 011461, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Porosnicu, AL (通讯作者)，Carol Davila Univ Med & Pharm, Dept Plast Surg & Reconstruct Microsurg, Bucharest 050474, Romania.; Porosnicu, AL (通讯作者)，Elias Emergency Univ Hosp, Dept Plast Surg & Reconstruct Microsurg, Bucharest 011461, Romania.
EM stefania-mihaela.riza@drd.umfcd.ro; andrei.porosnicu@umfcd.ro;
   ruxandra.sinescu@umfcd.ro
RI Porosnicu, Andrei Ludovic/PXW-4532-2026; Riza, Stefania/MDT-6082-2025;
   Sinescu, Ruxana Diana/ABD-2479-2020
OI Sinescu, Ruxana Diana/0000-0002-7591-0987
FU University of Medicine and Pharmacy Carol Davila
FX The publication of this paper was supported by the University of
   Medicine and Pharmacy Carol Davila through the Institutional Program
   "Publish not Perish".
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NR 48
TC 1
Z9 1
U1 4
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD MAY 13
PY 2025
VL 13
IS 10
AR 1130
DI 10.3390/healthcare13101130
PG 12
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 3AJ2B
UT WOS:001495613300001
PM 40427966
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Dawi, J
   Tumanyan, K
   Tomas, K
   Misakyan, Y
   Gargaloyan, A
   Gonzalez, E
   Hammi, M
   Tomas, S
   Venketaraman, V
AF Dawi, John
   Tumanyan, Kevin
   Tomas, Kirakos
   Misakyan, Yura
   Gargaloyan, Areg
   Gonzalez, Edgar
   Hammi, Mary
   Tomas, Serly
   Venketaraman, Vishwanath
TI Diabetic Foot Ulcers: Pathophysiology, Immune Dysregulation, and
   Emerging Therapeutic Strategies
SO BIOMEDICINES
LA English
DT Review
DE advanced glycation end products (AGEs); receptor for AGEs (RAGE)
   activation; macrophage polarization (M1/M2 imbalance); vascular
   endothelial growth factor (VEGF) therapy; negative pressure wound
   therapy (NPWT)
ID OXIDATIVE STRESS; WOUND CARE; MANAGEMENT; PATHOGENESIS; INFLAMMATION;
   SOCIETY; CELLS
AB Diabetic foot ulcers (DFUs) are among the most common and debilitating complications of diabetes mellitus (DM), affecting approximately 15-25% of patients and contributing to over 85% of non-traumatic amputations. DFUs impose a substantial clinical and economic burden due to high recurrence rates, prolonged wound care, and frequent hospitalizations, accounting for billions in healthcare costs worldwide. The multifactorial pathophysiology of DFUs involves peripheral neuropathy, peripheral arterial disease, chronic inflammation, and impaired tissue regeneration. Recent studies underscore the importance of immune dysregulation-specifically macrophage polarization imbalance, regulatory T cell dysfunction, and neutrophil impairment-as central mechanisms in wound chronicity. These immune disruptions sustain a pro-inflammatory environment dominated by cytokines, such as TNF-alpha, IL-1 beta, and IL-6, which impair angiogenesis and delay repair. This review provides an updated synthesis of DFU pathogenesis, emphasizing immune dysfunction and its therapeutic implications. We examine emerging strategies in immunomodulation, regenerative medicine, and AI-based wound technologies, including SGLT2 inhibitors, biologics, stem cell therapies, and smart dressing systems. These approaches hold promise for accelerating healing, reducing amputation risk, and personalizing future DFU care.
C1 [Dawi, John; Misakyan, Yura; Gargaloyan, Areg; Gonzalez, Edgar; Hammi, Mary; Venketaraman, Vishwanath] Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USA.
   [Tumanyan, Kevin; Tomas, Kirakos] Western Univ Hlth Sci, Coll Podiatr Med, Pomona, CA 91766 USA.
   [Tomas, Serly] Oakland Univ, William Beaumont Sch Med, Rochester, MI 48309 USA.
C3 Western University of Health Sciences; Western University of Health
   Sciences; Oakland University
RP Venketaraman, V (通讯作者)，Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USA.
EM john.dawi@westernu.edu; kevin.tumanyan@westernu.edu;
   kirakos.tomas@westernu.edu; yura.misakyan@westernu.edu;
   areg.gargaloyan@westernu.edu; edgar.gonzalez@westernu.edu;
   mary.hammi@westernu.edu; stomas@oakland.edu; vvenketaraman@westernu.edu
RI ; venketaraman, Vishwanath/AAW-6945-2020
OI Dawi, John/0009-0002-1860-3697; venketaraman,
   Vishwanath/0000-0002-2586-1160
FU NIH-NHLBI;  [2R15HL143545-02]
FX We appreciate the funding support from the NIH-NHLBI (2R15HL143545-02).
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NR 68
TC 120
Z9 139
U1 54
U2 73
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD APR 29
PY 2025
VL 13
IS 5
AR 1076
DI 10.3390/biomedicines13051076
PG 17
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 3BP9F
UT WOS:001496465400001
PM 40426903
OA Green Submitted, gold
HC Y
HP N
DA 2026-07-24
ER
PT J
AU Chiu, HS
   Huang, TS
   Chen, CT
   Lin, XY
   Liao, PC
   Liou, CC
   Hsu, CC
   Somvanshi, S
   Sumazin, P
   Hsu, PH
   Sun, CC
   Shyu, YC
AF Chiu, Hua-Sheng
   Huang, Ting-Shuo
   Chen, Chien-Tzung
   Lin, Xin-Yu
   Liao, Po-Cheng
   Liou, Cai-Cin
   Hsu, Chih-Chin
   Somvanshi, Sonal
   Sumazin, Pavel
   Hsu, Pang-Hung
   Sun, Chi-Chin
   Shyu, Yu-Chiau
TI Temporal Regulation of Early-Stage Cytokine Expression in Diabetic Wound
   Healing Under Negative Pressure Wound Therapy
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE negative pressure wound therapy (NPWT); diabetic (DB); wound healing;
   cytokine profiling
ID ENDOTHELIAL GROWTH-FACTOR; FOOT ULCERS; PDGF; METAANALYSIS; FIBROBLASTS;
   BIOLOGY
AB Negative pressure wound therapy (NPWT) is widely recognized for its efficacy in treating diabetic wounds, but the mechanisms involved in the wound healing process remain unclear. By examining changes in blood cytokine levels as molecular signaling precursors, we aim to provide a comprehensive cytokine profile to support adjunctive therapy research and clinical applications. A diabetic mouse wound model was established to compare cytokine profiles between NPWT-treated and standard dressing groups, identifying key signaling candidates that may facilitate wound healing. By integrating normal mouse data with large-scale cytokine analysis, we developed a time-stratified NPWT approach to track acute-phase cytokine fluctuations in diabetic conditions. NPWT did not significantly enhance coagulation-related cytokine expression but effectively reduced inflammation, albeit with a delayed regulatory effect compared to wild-type mice. A one-sided binomial test revealed that NPWT advanced the cytokine expression peak from 16 to 2 h, partially restoring the early healing pattern seen in normal mice and suggesting its potential role in modulating early-stage wound repair. These findings provide novel insights into early cytokine regulation during wound healing and highlight the potential of NPWT to inform therapeutic strategies. This refined monitoring approach may contribute to improved clinical decision-making and support enhanced wound management in diabetic patients.
C1 [Chiu, Hua-Sheng; Somvanshi, Sonal; Sumazin, Pavel] Baylor Coll Med, Dept Pediat, Texas Childrens Canc Ctr, Houston, TX 77030 USA.
   [Huang, Ting-Shuo] Jen Ai Hosp, Dept Gen Surg, Taichung 400, Taiwan.
   [Huang, Ting-Shuo] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan 333, Taiwan.
   [Chen, Chien-Tzung] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Taoyuan 333, Taiwan.
   [Chen, Chien-Tzung] Chang Gung Univ, Craniofacial Res Ctr, Taoyuan 333, Taiwan.
   [Lin, Xin-Yu; Liao, Po-Cheng; Liou, Cai-Cin; Shyu, Yu-Chiau] Chang Gung Mem Hosp, Community Med Res Ctr, Keelung Branch, Keelung 204, Taiwan.
   [Hsu, Chih-Chin; Sun, Chi-Chin] Chang Gung Univ, Coll Med, Sch Med, Taoyuan 333, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Keelung Branch, Keelung 204, Taiwan.
   [Hsu, Pang-Hung] Natl Taiwan Ocean Univ, Dept Biosci & Biotechnol, Keelung 202, Taiwan.
   [Sun, Chi-Chin] Chang Gung Mem Hosp, Dept Ophthalmol, Keelung Branch, Keelung 204, Taiwan.
   [Shyu, Yu-Chiau] Chang Gung Univ Sci & Technol, Dept Nursing, Taoyuan 333, Taiwan.
C3 Texas Children's Cancer Center; Baylor College of Medicine; Chang Gung
   University; Chang Gung Memorial Hospital; Chang Gung University; Chang
   Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; National Taiwan Ocean University; Chang Gung Memorial
   Hospital; Chang Gung University of Science & Technology
RP Shyu, YC (通讯作者)，Chang Gung Mem Hosp, Community Med Res Ctr, Keelung Branch, Keelung 204, Taiwan.; Shyu, YC (通讯作者)，Chang Gung Univ Sci & Technol, Dept Nursing, Taoyuan 333, Taiwan.
EM hua-sheng.chiu@bcm.edu; huangts1234@gmail.com; ctchenap@cgmh.org.tw;
   love20070810@gmail.com; henryshome@gmail.com; nice302a@gmail.com;
   steele0618@gmail.com; sonal.somvanshi@bcm.edu; pavel.sumazin@bcm.edu;
   phsu@ntou.edu.tw; chichinsun@gmail.com; yuchiaushyu@gmail.com
RI Sumazin, Pavel/AAE-6607-2020; Chiu, Hua-Sheng/I-7150-2019; Hsu,
   Pang-Hung/C-5587-2018; Huang, Ting-Shuo/ABD-3205-2021
OI Sumazin, Pavel/0000-0002-1215-4977; Shyu, Yu-Chiau/0000-0003-1747-2226;
   Hsu, Chih-Chin/0000-0002-5558-3456; Lin, Xin-Yu/0000-0003-3311-1754;
   Chiu, Hua-Sheng/0000-0002-0296-5653; Hsu, Pang-Hung/0000-0001-6873-6434;
   
FU the Chang Gung Memorial Hospital Research Projects [CMRPG2L0311]; Chang
   Gung Memorial Hospital Research Projects
FX This work was supported by the Chang Gung Memorial Hospital Research
   Projects CMRPG2L0311.
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NR 43
TC 1
Z9 1
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY 13
PY 2025
VL 26
IS 10
AR 4634
DI 10.3390/ijms26104634
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 3BQ1Y
UT WOS:001496472500001
PM 40429778
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Palomar-Albert, D
   Zamora-Ortiz, J
   Palomar-Llatas, F
   Escudero-Martínez, M
   Naranjo-Cuellar, A
   Pastor-Orduña, MI
AF Palomar-Albert, David
   Zamora-Ortiz, Jorge
   Palomar-Llatas, Federico
   Escudero-Martinez, Marta
   Naranjo-Cuellar, Alba
   Pastor-Orduna, Maria Isabel
TI Longitudinal Observational Study on Quality of Life in Patients with
   Chronic Wounds Using DLQI and EQ-5D
SO MEDICINA-LITHUANIA
LA English
DT Article
DE chronic wounds; quality of life; DLQI; EQ-5D; longitudinal study; wound
   treatment; observational study; patient-centered care; venous ulcers
ID LEG ULCERS; GUIDELINES
AB Background and Objectives: Chronic wounds severely impair patients' quality of life (QoL), impacting physical, emotional, and functional well-being. Understanding the multidimensional effects of treatment is key to implementing effective, patient-centered care strategies. This study aimed to assess changes in QoL among patients with chronic wounds using the Dermatology Life Quality Index (DLQI) and EuroQol-5D (EQ-5D), comparing outcomes across treatment modalities. Materials and Methods: A longitudinal observational study was conducted between 2019 and 2024 across three hospitals in the Valencian Community. A total of 278 patients with venous lower-limb ulcers of more than six weeks' duration were included. Quality-of-life assessments were performed at baseline, one-month follow-up, and discharge. Treatments included alginate, foam, moist wound healing (MWH), compression therapy, and negative-pressure wound therapy (NPWT). Statistical analysis involved Friedman's test and repeated-measures ANOVA. Results: Significant improvements were observed in overall QoL across most treatment modalities. EQ-5D scores progressively increased, while DLQI scores decreased. Pain, embarrassment, and limitations in daily life (e.g., shopping and social activities) showed marked reductions. MWH and foam demonstrated the most favorable impact on QoL, while NPWT showed more modest improvements, possibly due to patient complexity. Notably, the variable "sexuality" remained unchanged (mean = 0.00), possibly due to underreporting or communication barriers. Conclusions: Chronic wound treatments significantly improve patients' quality of life, particularly in terms of pain and social functioning. The use of combined tools (DLQI and EQ-5D) allows for a more comprehensive understanding of these outcomes. These findings highlight the importance of tailoring wound care to individual needs and addressing psychosocial domains, including sexuality. Community nursing, nutritional support, and long-term follow-up should be incorporated into care plans to optimize results, especially in older adults.
C1 [Palomar-Albert, David; Palomar-Llatas, Federico; Escudero-Martinez, Marta; Naranjo-Cuellar, Alba; Pastor-Orduna, Maria Isabel] Catholic Univ Valencia SanVicente Martir, Integr & Skin Care, Integr & Skin Care Res Grp, Valencia 46001, Spain.
   [Zamora-Ortiz, Jorge] Valencia Gen Hosp Dept, Ulcers Unit, Valencia 46014, Spain.
   [Pastor-Orduna, Maria Isabel] Catholic Univ Valencia San Vicente Martir, Doctoral Sch, Valencia 46001, Spain.
   [Pastor-Orduna, Maria Isabel] Sagunto Hosp, Adv Nursing Unit Rheumatol & Rehabil, Sagunto 46500, Spain.
C3 Universidad Catolica de Valencia San Vicente Martir
RP Pastor-Orduña, MI (通讯作者)，Catholic Univ Valencia SanVicente Martir, Integr & Skin Care, Integr & Skin Care Res Grp, Valencia 46001, Spain.; Pastor-Orduña, MI (通讯作者)，Catholic Univ Valencia San Vicente Martir, Doctoral Sch, Valencia 46001, Spain.; Pastor-Orduña, MI (通讯作者)，Sagunto Hosp, Adv Nursing Unit Rheumatol & Rehabil, Sagunto 46500, Spain.
EM david.palomar@ucv.es; jorzaor@gmail.com; federico.palomar@ucv.es;
   marta.escudero@ucv.es; albanaranjo_89@hotmail.com; pastor_marord@gva.es
OI Pastor-Orduna, Maria-Isabel/0000-0003-4849-5922
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NR 21
TC 2
Z9 2
U1 1
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD MAY 17
PY 2025
VL 61
IS 5
AR 907
DI 10.3390/medicina61050907
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3BR3D
UT WOS:001496501600001
PM 40428865
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Miller, T
   Clark, J
AF Miller, Taylor
   Clark, Jaclyn
TI Advanced Wound Care Strategies in Patients with NSTIs
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE wound care; wound healing; necrotizing soft tissue infections;
   postoperative care; surgical wound infections
ID HYPERBARIC-OXYGEN TREATMENT; DIABETIC FOOT; PREVENTION; MANAGEMENT;
   DRESSINGS; GUIDELINE
AB Necrotizing soft tissue infections (NSTIs) are rapidly progressive, life-threatening infections associated with significant morbidity and mortality. Surgical debridement, the cornerstone of treatment, often results in extensive, complex wounds located in anatomically difficult regions. Management of these wounds can be challenging, especially for surgeons with limited experience in complex wound care and reconstruction. Yet, proper management of these wounds is critical to patient recovery and long-term quality of life. This review provides a comprehensive overview of current strategies in NSTI wound reconstruction. It begins by outlining the biological underpinnings of wound healing and the unique challenges posed by NSTI-related wounds. The review then explores a range of dressing materials and advanced wound care modalities, including negative pressure wound therapy, cellular and tissue-based products, and hyperbaric therapy. Finally, it presents a guide to surgical reconstruction techniques, including skin grafting and flap coverage. By consolidating current knowledge and practical guidance, this review seeks to support generalist and acute care surgeons with the knowledge needed to optimize wound healing, enhance functional outcomes, and improve quality of life for NSTI survivors.
C1 [Miller, Taylor; Clark, Jaclyn] R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP Miller, T (通讯作者)，R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA.
EM taylor.miller@umm.edu; jaclyn.clark@som.umaryland.edu
OI Miller, Taylor/0000-0003-0342-4768
CR academic.oup, Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases|Oxford Academic
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NR 48
TC 1
Z9 1
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY 17
PY 2025
VL 14
IS 10
AR 3514
DI 10.3390/jcm14103514
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3CD8H
UT WOS:001496828200001
PM 40429509
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhu, YS
   Lin, YZ
   Xie, SJ
   Yang, MX
   Zhang, W
   Wu, MJ
   Liu, YF
   Xu, DY
   Xian, SY
   Tong, XR
   Huang, J
   Jiang, LF
   Guo, XY
   Gu, MY
   Yu, HK
   Ding, XR
   Li, YX
   Du, YY
   He, H
   Lu, JY
   Huang, RZ
   Ji, SZ
AF Zhu, Yushu
   Lin, Yizhen
   Xie, Sujie
   Yang, Mingxuan
   Zhang, Wei
   Wu, Minjuan
   Liu, Yifan
   Xu, Dayuan
   Xian, Shuyuan
   Tong, Xirui
   Huang, Jie
   Jiang, Luofeng
   Guo, Xinya
   Gu, Minyi
   Yu, Hengkai
   Ding, Xinran
   Li, Yixu
   Du, Yiyao
   He, Heng
   Lu, Jianyu
   Huang, Runzhi
   Ji, Shizhao
TI Mapping intellectual structures and research hotspots of chronic wound
   in global perspective
SO REGENERATIVE THERAPY
LA English
DT Article
DE Chronic wounds; Healing; Management; Negative pressure wound therapy
   (NPWT); Dressings
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT WOUNDS; BED PREPARATION; THERAPY;
   MULTICENTER; ULCERS; MECHANISM; DRESSINGS; DEBRIDEMENT; CHALLENGES
AB Background: Chronic wounds included but were not limited to diabetes foot ulcers, venous leg ulcers and pressure ulcers. The challenge of difficult healing placed a heavy burden on patients and society. Our objective was to explain the healing process of chronic wounds and the development of treatment technologies in the past few years and to provide relevant, valuable information. Methods: Our scientific publications were retrieved from the core collection of the Web of Science (WoSCC) database collection. The bibliometric visualization and analysis were performed by the software Biblioshiny based on R-bibliometrix. VOSviewer software and Citespace software were responsible for the validation of the results. Results: A total of 8129 articles related to wound healing in chronic wounds were retrieved. The countries, institutions, and journals with the highest number of publications were the USA, the N8 research partnership, and the Journal of Wound Care, respectively. Armstrong DG and Dumville JC were the most influential authors in this field. The keyword analysis showed two key clusters of keywords, including "dressings" and "management". Trend topics analysis revealed frequent keywords in recent years, including "nanofibers" and "injectable hydrogels". Conclusion: Our research was the first to reveal the cellular and molecular mechanisms and key clinical management strategies in the healing process of chronic wounds in the future through metrological and systematic evaluation, which may have important translational value in the future. (c) 2025 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/lice nses/by-nc-nd/4.0/).
C1 [Zhu, Yushu; Xie, Sujie; Zhang, Wei; Xu, Dayuan; Xian, Shuyuan; Tong, Xirui; Huang, Jie; Jiang, Luofeng; Guo, Xinya; Gu, Minyi; Yu, Hengkai; Ding, Xinran; Li, Yixu; Du, Yiyao; He, Heng; Lu, Jianyu; Huang, Runzhi; Ji, Shizhao] Naval Med Univ, Affiliated Hosp 1, Dept Burn Surg, Shanghai, Peoples R China.
   [Lin, Yizhen; Yang, Mingxuan] Naval Med Univ, Shanghai 200025, Peoples R China.
   [Wu, Minjuan] Naval Mil Med Univ, Dept Histol & Embryol, Shanghai 200433, Peoples R China.
   [Liu, Yifan] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Urol, Shanghai 200092, Peoples R China.
   [Zhu, Yushu; Xie, Sujie; Zhang, Wei; Xu, Dayuan; Xian, Shuyuan; Tong, Xirui; Huang, Jie; Jiang, Luofeng; Guo, Xinya; Gu, Minyi; Yu, Hengkai; Ding, Xinran; Li, Yixu; Du, Yiyao; He, Heng; Lu, Jianyu; Huang, Runzhi; Ji, Shizhao] Chinese Acad Med Sci, Res Unit Key Tech Treatment Burns & Combined Burns, Beijing, Peoples R China.
C3 Naval Medical University; Naval Medical University; Naval Medical
   University; Shanghai Jiao Tong University; Chinese Academy of Medical
   Sciences - Peking Union Medical College
RP Lu, JY; Huang, RZ; Ji, SZ (通讯作者)，Naval Med Univ, Affiliated Hosp 1, Dept Burn Surg, Shanghai, Peoples R China.
EM 578198334@qq.com; runzhihuang2022@163.com; shizhaoji2022@163.com
RI jiang, luofeng/GPK-2450-2022; Yifan, Liu/AHD-1515-2022; Huang,
   Runzhi/KLY-6298-2024; Yixu, Li/JZD-7782-2024
FU National Natural Science Foundation of China [81930057, 82472546]; CAMS
   Innovation Fund for Medical Sciences [2019-I2M-5-076]; Shanghai Top
   Priority Research Center Project [2023ZZ02013]; Excellent Academic
   Leader Project of Shanghai Science and Technology Committee [23XD142500
   0]; Deep Blue Talent Project of Naval Medical University; Postdoctoral
   Fellowship Program of CPSF [96926]; Shanghai Rising-Star Program
   (Sailing Special Program) [23YF145840 0]
FX This work was supported by the National Natural Science Foundation of
   China (81930057, 82472546) , CAMS Innovation Fund for Medical Sciences
   (2019-I2M-5-076) , Shanghai Top Priority Research Center Project
   (2023ZZ02013) , the Excellent Academic Leader Project of Shanghai
   Science and Technology Committee (23XD142500 0) , Deep Blue Talent
   Project of Naval Medical University, Postdoctoral Fellowship Program of
   CPSF (96926) and Shanghai Rising-Star Program (Sailing Special Program)
   (No. 23YF145840 0) . The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 69
TC 0
Z9 0
U1 2
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3204
J9 REGEN THER
JI Regen. Ther.
PD DEC
PY 2025
VL 30
BP 47
EP 62
DI 10.1016/j.reth.2025.05.002
EA MAY 2025
PG 16
WC Cell & Tissue Engineering; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA 3DJ7O
UT WOS:001497662200001
PM 40491561
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kamata, T
   Yoshida, S
   Hirai, Y
   Karita, R
   Onozato, Y
   Wada, H
   Anayama, T
AF Kamata, Toshiko
   Yoshida, Shigetoshi
   Hirai, Yuki
   Karita, Ryo
   Onozato, Yuki
   Wada, Hironobu
   Anayama, Takashi
TI Case Series of Blowhole Creation with or without Negative Pressure Wound
   Therapy for Severe Subcutaneous Emphysema
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE blowhole; negative pressure wound therapy; subcutaneous emphysema; Japan
AB Severe subcutaneous emphysema that is refractory to chest tube drainage can result in significant patient discomfort, airway compromise, and hemodynamic instability. Various interventional approaches, including subcutaneous drain insertion and the blowhole technique, with or without negative pressure wound therapy (NPWT), have been proposed to manage this condition. In this case series, we describe 10 patients who developed severe subcutaneous emphysema following surgery or pneumothorax and were treated using the blowhole technique, with or without NPWT. A Wound Protector/Retractor XXS or LapProtector was used to maintain the patency of the blowhole, facilitating continuous decompression. In cases with more extensive emphysema, the application of NPWT led to rapid respiratory improvement, thereby enabling additional invasive interventions to address the underlying pulmonary air leak. These findings highlight the potential utility of a structured approach incorporating NPWT for the management of severe subcutaneous emphysema, particularly in cases refractory to conventional chest tube drainage.
C1 [Kamata, Toshiko; Yoshida, Shigetoshi; Onozato, Yuki; Wada, Hironobu; Anayama, Takashi] Int Univ Hlth & Welf, Sch Med, Dept Thorac Surg, 4-3 Kozunomori, Narita, Chiba 2868686, Japan.
   [Kamata, Toshiko] Int Univ Hlth & Welf, Atami Hosp, Dept Thorac Surg, Atami, Shizuoka, Japan.
   [Yoshida, Shigetoshi; Hirai, Yuki; Karita, Ryo; Onozato, Yuki; Wada, Hironobu; Anayama, Takashi] Int Univ Hlth & Welf, Narita Hosp, Dept Thorac Surg, Narita, Chiba, Japan.
C3 International University of Health & Welfare; International University
   of Health & Welfare; International University of Health & Welfare
RP Yoshida, S (通讯作者)，Int Univ Hlth & Welf, Sch Med, Dept Thorac Surg, 4-3 Kozunomori, Narita, Chiba 2868686, Japan.
EM shigeyoshida@iuhw.ac.jp
RI ; Karita, Ryo/IYJ-4815-2023; Onozato, Yuki/GYJ-0819-2022
OI Wada, Hironobu/0000-0002-5691-4886; Karita, Ryo/0009-0000-5911-4799; 
CR Bouwmeester NH, 2020, SAGE OPEN MED CASE R, V8, DOI 10.1177/2050313X20918989
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   Huan NC, 2020, RESPIROL CASE REP, V8, DOI 10.1002/rcr2.544
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   Towe C, 2014, BMJ Case Rep, V2014
NR 11
TC 0
Z9 0
U1 0
U2 2
PU Int Acad Publishing Co Ltd
PI Tokyo
PA Academy center, 358-5 yamabukicho, shinjuku-ku, Tokyo, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2025
VL 31
IS 1
AR 2500034
DI 10.5761/atcs.cr.25-00034
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 3ED7P
UT WOS:001498189200001
PM 40436767
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kopechek, KJ
   Patel, HV
   Koch, GE
AF Kopechek, Kyle J.
   Patel, Hiren V.
   Koch, George E.
TI Modern Management of Fournier's Gangrene
SO CURRENT UROLOGY REPORTS
LA English
DT Review
DE Fournier's gangrene; Necrotizing soft tissue infection; Skin-sparing
   debridement; Wound care; Genital reconstruction; Wound closure
ID SOFT-TISSUE INFECTIONS; VACUUM-ASSISTED CLOSURE; HYPERBARIC-OXYGEN;
   INTRAVENOUS IMMUNOGLOBULIN; SKIN; RECONSTRUCTION; MORTALITY; DIAGNOSIS;
   ETIOLOGY; OUTCOMES
AB Purpose of reviewThis review explores new evidence in Fournier's Gangrene management, emphasizing survivorship. We highlight the shift toward skin-sparing debridement techniques, new reconstructive strategies, and highlight limited evidence on outcomes. Additionally, we examine recent evidence on diagnosis, antimicrobial therapy, adjunctive treatments, and post-operative wound care.Recent findingsNew evidence supports the feasibility of skin-sparing debridement, reducing the need for extensive reconstruction while improving primary closure rates and lowering healthcare costs. Advances in reconstructive techniques accelerate wound healing and shorten hospital stays. Optimized wound management-integrating antimicrobial solutions, negative pressure therapy, and targeted antibiotics-continues to improve recovery while minimizing morbidity and mortality.SummaryModern Fournier's management prioritizes early recognition, tissue preservation, and early genital reconstruction. Despite advancements, gaps remain in early diagnosis and long-term outcomes after the index admission. Further research on post-reconstruction recovery is essential to refine treatment protocols and determine quality of life for affected patients.
C1 [Kopechek, Kyle J.; Patel, Hiren V.; Koch, George E.] Ohio State Univ, Wexner Med Ctr, Dept Urol, 915 Olentangy River Rd,Suite 3117, Columbus, OH 43212 USA.
   [Koch, George E.] Univ Washington, Dept Urol, Seattle, WA USA.
C3 University System of Ohio; Ohio State University; University of
   Washington; University of Washington Seattle
RP Kopechek, KJ (通讯作者)，Ohio State Univ, Wexner Med Ctr, Dept Urol, 915 Olentangy River Rd,Suite 3117, Columbus, OH 43212 USA.
EM Kyle.Kopechek@osumc.edu
OI Patel, Hiren/0000-0002-6475-670X
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NR 74
TC 8
Z9 10
U1 8
U2 14
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1527-2737
EI 1534-6285
J9 CURR UROL REP
JI Curr. Urol. Rep.
PD JUN 2
PY 2025
VL 26
IS 1
AR 47
DI 10.1007/s11934-025-01275-3
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 3HM0H
UT WOS:001500450200001
PM 40455358
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Maheshwari, V
   Danish, 
   Olkha, V
   Dhingra, M
   Sharma, C
   Regmi, A
AF Maheshwari, Vikas
   Danish, V
   Olkha, Vikas
   Dhingra, Mohit
   Sharma, Cury
   Regmi, Anil
TI Calcific Myonecrosis: Case Report of a Rare Clinical Presentation and
   Literature Review
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Calcific myonecrosis; En bloc excision; Antero-lateral compartment;
   Vacuum-assisted closure (VAC); Surgical management; Case report
ID DIAGNOSIS
AB Introduction and ImportanceCalcific myonecrosis is a rare entity characterized by coagulative and liquefactive necrosis with calcifications of the entire muscle mass of the involved compartment secondary to post-traumatic compartment syndrome. There is limited literature on the rare disease with technical difficulties and pitfalls of operative procedures in these patients.Presentation of CaseA 52-year-old male presented with complaints of swelling over his right leg with discharging sinus over the past 2 years following a surgical intervention. He was diagnosed as a case of calcific myonecrosis based on history and clinico-radio-histological correlation and was managed successfully with en bloc excision with vacuum-assisted closure (VAC) of wound.Clinical DiscussionA rare musculoskeletal condition is characterized by muscle necrosis and extensive calcification within a limb compartment, typically following post-traumatic compartment syndrome involving muscle and neurovascular structures. Diagnosis relies heavily on radiological findings, such as calcifications and adjacent bone erosions, while histopathology is crucial to exclude malignancy. A high index of clinical suspicion is essential for timely identification.ConclusionCalcific myonecrosis requires a multi-factorial approach to reach to a diagnosis, with ruling out the differentials and proper preoperative plan are the key to success. If un-infected, it is a "Touch me not disease"; however, through debridement or en-mass excision of compartment with VAC therapy should be considered for infected cases.
C1 [Maheshwari, Vikas; Olkha, Vikas; Dhingra, Mohit; Sharma, Cury; Regmi, Anil] All India Inst Med Sci, Dept Orthopaed, Rishikesh, India.
C3 All India Institute of Medical Sciences (AIIMS) Rishikesh
RP Dhingra, M (通讯作者)，All India Inst Med Sci, Dept Orthopaed, Rishikesh, India.
EM 111vikasmaheshwari@gmail.com; danishvayoli@gmail.com; viksvx@gmail.com;
   modisbanu77@gmail.com; curiesharma10@gmail.com; regmiaanil@gmail.com
RI Regmi, Anil/NBX-3164-2025
OI Regmi, Anil/0000-0002-9182-4851; , vikas/0009-0004-7621-7369;
   Maheshwari, Vikas/0000-0002-8631-6334
CR Angelini A, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55090542
   elsevier, CALCIFIC MYONECROSIS
   Gangrade K, 2019, Case Reports in Orthopedic Research, V2, P47, DOI [10.1159/000502031, 10.1159/000502031, DOI 10.1159/000502031]
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   Matar HE, 2018, ANN ROY COLL SURG, V100, pE158, DOI 10.1308/rcsann.2018.0077
   Muramatsu K, 2009, ARCH ORTHOP TRAUM SU, V129, P935, DOI 10.1007/s00402-009-0890-0
   Okada A, 2009, UPSALA J MED SCI, V114, P178, DOI 10.1080/03009730903016050
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   Waller Garrett, 2023, J Orthop Case Rep, V13, P122, DOI [10.13107/jocr.2023.v13.i11.4030, 10.13107/jocr.2023.v13.i11.4030]
NR 11
TC 1
Z9 1
U1 1
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD JUL
PY 2025
VL 59
IS 7
BP 1000
EP 1006
DI 10.1007/s43465-025-01428-z
EA JUN 2025
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 4TZ8C
UT WOS:001501874400001
PM 40657225
OA Green Accepted
DA 2026-07-24
ER
PT J
AU Tam, SKM
   Nguyen, CL
   Warrier, SK
   Ofri, A
AF Tam, Sze Ki Melanie
   Nguyen, Chu Luan
   Warrier, Sanjay Kumar
   Ofri, Adam
TI Closed incision negative pressure wound therapy in oncoplastic breast
   surgery: A single-centre analysis and literature review
SO SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND
   IRELAND
LA English
DT Review
DE Negative pressure wound therapy; PICO dressing; Oncoplastic breast
   surgery; Wound outcomes
ID RECONSTRUCTION
AB Background: Surgical wound complications cause substantial morbidity. Data on the effectiveness of closed incision negative pressure wound therapy (ciNPWT) as a prophylaxis of surgical wound complications in oncoplastic breast surgery (OPBS) is sparse. This study assessed the routine prophylactic use of ciNPWT in OPBS, explored the trend in outcomes associated with its application and compared subsequent wound outcomes with the existing literature. Method: A single-surgeon retrospective analysis was conducted on OPBS patients from January 2017 to December 2018. Cumulative sum (CUSUM) analysis was adopted to track the trend of wound complication rates over time. Following the exclusion of data potentially skewed by early procedural adaptation, the study compared the remaining cohort's wound complication rates to those reported in current literature. Results: A total of 209 breast wounds post OPBS were included in the analysis. CUSUM analysis revealed a higher rate of complications at the initial phase of ciNPWT implementation, which significantly decreased and plateaued after eleven months, indicating improved outcome (p < 0.001). Complication rates in the first month of ciNPWT introduction were markedly higher than in the subsequent two-year period (p = 0.02) and was omitted from further analysis. The final ciNPWT cohort showed a significantly lower complication rate than standard dressing usage reported in published studies (16.7 % versus 33.9 %, p < 0.001). Conclusion: Adoption of prophylactic ciNPWT resulted in gradual decline of wound complications over time, thus shows significant promise in enhancing wound outcomes post OPBS.
C1 [Tam, Sze Ki Melanie; Nguyen, Chu Luan; Warrier, Sanjay Kumar] Chris OBrien Lifehouse, Dept Breast Surg, Camperdown, NSW 2050, Australia.
   [Nguyen, Chu Luan; Warrier, Sanjay Kumar] Royal Prince Alfred Hosp, Dept Surg, Camperdown, NSW 2050, Australia.
   [Nguyen, Chu Luan; Warrier, Sanjay Kumar; Ofri, Adam] Univ Sydney, Fac Med & Hlth, Sydney, NSW 2050, Australia.
   [Ofri, Adam] Mater Hosp, Breast & Endocrine Dept, Sydney, NSW 2060, Australia.
C3 Chris O'Brien Lifehouse; NSW Health; Royal Prince Alfred Hospital;
   University of Sydney; University of Sydney
RP Tam, SKM (通讯作者)，Chris OBrien Lifehouse, Dept Breast Surg, Camperdown, NSW 2050, Australia.
EM skmelanietam@gmail.com
RI ; Ofri, Adam/ABA-8021-2020
OI Warrier, Sanjay/0009-0000-6863-1296; Ofri, Adam/0000-0003-4940-4674;
   Nguyen, Chu Luan/0000-0002-4630-6182
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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   Vidya R, 2023, PRS-GLOB OPEN, V11, DOI 10.1097/GOX.0000000000005488
NR 21
TC 1
Z9 1
U1 0
U2 0
PU ROYAL COLLEGE SURGEONS EDINBURGH
PI EDINBURGH
PA NICOLSON ST, EDINBURGH EH8 9DW, SCOTLAND
SN 1479-666X
EI 2405-5840
J9 SURG-J R COLL SURG E
JI Surg. J. R. Coll. Surg. Edinb. Irel.
PD JUN
PY 2025
VL 23
IS 3
BP 174
EP 179
DI 10.1016/j.surge.2025.01.009
EA MAY 2025
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3KR4S
UT WOS:001502644400008
PM 39934063
OA hybrid
DA 2026-07-24
ER
PT J
AU Meng, FZ
   Ye, JW
   Wu, XM
   Li, JC
   Bian, B
   Li, WS
   Pan, XH
AF Meng, Fengzhen
   Ye, Jianwen
   Wu, Xiaomin
   Li, Jianchi
   Bian, Bin
   Li, Wensong
   Pan, Xiaohua
TI Negative Pressure Wound Therapy Using a New Pressure Monitoring Device
   for Wound Treatment: Results of an Animal Model
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE dressing; negative pressure wound therapy; pressure monitoring;
   real-time monitoring; sensing chip; wound healing
ID SURGICAL-SITE INFECTION; DELIVERY; CLOSURE
AB Background. Negative pressure wound therapy (NPWT) is a widely used therapeutic approach for skin and soft tissue defects, and selecting an appropriate negative pressure value is critically important. Objective. To develop a wound pressure monitoring dressing (WPMD) integrating a novel pressure sensing chip with a previously developed polyvinyl acetate foam dressing. Materials and Methods. Sprague-Dawley male rats were randomly divided into 3 groups to receive-125 mm Hg pressure with the WPMD, -75 mm Hg pressure with the WPMD, or wound dressing without negative pressure (control). Data on pressure changes and wound conditions were collected over 7 consecutive days. Monitoring included pressure changes, gross wound morphology observations, and histopathological analyses. Results. Monitoring data revealed pressure variations during wound healing ranging from-128 mm Hg to-63 mm Hg in the-125 mm Hg preset group, and from-72mm Hg to-37 mm Hg in the-75 mm Hg preset group. The WPMD groups exhibited higher wound closure rates than the control group. Ki67, vascular endothelial growth factor receptor 2, transforming growth factor beta 1, and CD31 expression levels were elevated in the WPMD groups compared with the control group. Conclusion. The WPMD accurately and sensitively detected real-time pressure changes on wound surfaces under different preset negative pressure values (-125 mm Hg and-75 mm Hg). Furthermore, NPWT significantly accelerated wound healing in the rat model, and the healing rates were better in the-75 mm Hg group than in the-125 mm Hg group at day 5 and day 7. These results underscore the potential application of the WPMD in investigating the relationship between negative pressure values and wound healing rates across various wound types during treatment.
C1 [Meng, Fengzhen; Ye, Jianwen; Wu, Xiaomin; Bian, Bin; Li, Wensong; Pan, Xiaohua] Shenzhen Univ, Peoples Hosp Baoan Shenzhen, Affiliated Hosp 2, Dept Orthopaed & Traumatol, Shenzhen, Peoples R China.
   [Li, Jianchi] Jinan Univ, Affiliated Hosp 1, Key Lab Regenerat Med, Inst New Technol Plast Surg,Dept Plast Surg,Minist, Guangzhou, Peoples R China.
C3 Shenzhen University; Jinan University
RP Pan, XH (通讯作者)，Peoples Hosp Baoan Shenzhen, Dept Orthopaed & Traumatol, Baocheng Longjing 2nd Rd 118, Shenzhen 518101, Peoples R China.
EM szpxh4141@foxmail.com
FU Shenzhen Science and Technology Innovation Council of China
   [JCYJ20220530142618040]; Research Project of Bao'an District Medical
   Association in Shenzhen [BAYXH2023004]; Sanming Project of Medicine in
   Shenzhen [SZSM202106019]
FX Financial grant support was received from the Shenzhen Science and
   Technology Innovation Council of China (JCYJ20220530142618040) ,
   Research Project of Bao'an District Medical Association in Shenzhen
   (BAYXH2023004) , and Sanming Project of Medicine in Shenzhen
   (SZSM202106019) to support study materials and editorial assistance.
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NR 24
TC 0
Z9 1
U1 1
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2025
VL 37
IS 4
BP 145
EP 151
DI 10.25270/wnds/24109
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 3KV6M
UT WOS:001502754300002
PM 40368389
DA 2026-07-24
ER
PT J
AU Vilkins, A
   Nherera, L
   Searle, R
   Welsh, T
AF Vilkins, Annmarie
   Nherera, Leo
   Searle, Richard
   Welsh, Tia
TI Comparison of the Effectiveness of Two Prophylactic Single-Use Negative
   Pressure Wound Therapy Devices in Reducing Surgical Site Complications
   After Cesarean Delivery: Insights From a Large US Claims Database
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE single-use negative pressure wound therapy; surgical site complications;
   surgical site infections; cesarean delivery; real-world evidence
ID INFECTION; SECTION
AB Background. Single-use negative pressure wound therapy (sNPWT) has emerged as a promising intervention for patients at high risk of surgical site complications (SSCs) after a cesarean delivery. However, the available studies primarily compare negative pressure wound therapy to standard dressings rather than evaluating differences between negative pressure wound therapy devices or pressure settings. Objective. To compare the effectiveness of 2 commonly used sNPWT devices, a -80 mm Hg device and a -125 mm Hg device, in reducing the risk of SSCs following cesarean delivery. Materials and Methods. Real-world data were obtained from a large claims database in the United States from January 2017 through June 2022. Adult patients who had an inpatient encounter in which the -80 mm Hg device or the -125 mm Hg device was used after a cesarean delivery were included. Propensity score matching was used to balance the cohorts. Study end points included incidence of overall surgical site infection (SSI), superficial SSI, dehiscence, seroma, hematoma, deep SSI, length of stay (LOS), and costs. Results. The study included 5332 cases in each group. Overall SSI, superficial SSI, dehiscence, seroma, and costs were significantly lower with the -80 mm Hg device compared with the -125 mm Hg device (P <= .05). No differences between the 2 devices were observed for hematoma, deep SSI, and LOS (P > .05). Conclusion. Of the 2 commonly used sNPWT devices, use of the -80 mm Hg device was associated with a lower likelihood of developing overall SSI, superficial SSI, dehiscence, and seroma, and was associated with lower costs after cesarean delivery compared with the -125 mm Hg device. There were nonsignificant differences in LOS, deep SSI, and hematoma. Further studies are required to confirm these findings.
C1 [Vilkins, Annmarie] Henry Ford Med Ctr, Detroit, MI USA.
   [Nherera, Leo; Searle, Richard] Smith Nephew, Ft Worth, TX USA.
   [Welsh, Tia] Valley Hlth Syst, Ridgewood, NJ USA.
C3 Henry Ford Health System; Smith & Nephew
RP Welsh, T (通讯作者)，Valley Hlth Syst, Obstet & Gynecol, 223 N Dien Ave, Ridgewood, NJ 07450 USA.
EM welsti@Valleyhealth.com
FU Smith + Nephew, Inc.
FX Funding: This study was funded by Smith + Nephew, Inc.
CR American Hospital Association, 2016, Trends in inpatient utilization in community hospitals, 1995-2016
   [Anonymous], 2019, MedTech Innovation Briefing
   CDC National Healthcare Safety Network, 2024, Surgical Site Infection Event (SSI)
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NR 31
TC 0
Z9 0
U1 1
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2025
VL 37
IS 4
DI 10.25270/wnds/24183
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 3KV6M
UT WOS:001502754300003
PM 40368390
DA 2026-07-24
ER
PT J
AU Sziklavari, Z
   Hammoudeh, S
   Petrone, AM
   Stange, S
   Orban, K
   Fekete, JT
   Hofmann, HS
AF Sziklavari, Zsolt
   Hammoudeh, Sameer
   Petrone, Ana-Maria
   Stange, Sebastian
   Orban, Karoly
   Fekete, Janos Tibor
   Hofmann, Hans-Stefan
TI Outcomes of Vacuum-Assisted Closure in Patients with Empyema Thoracis: A
   10-Year Experience
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID PARAPNEUMONIC EMPYEMA; PLEURAL EMPYEMA; MANAGEMENT; SOCIETY
AB BACKGROUND Video-assisted thoracic surgery is currently the recommended treatment for patients with empyema thoracis. However, open-window thoracostomy (OWT) is not uncommon and is performed as a last resort in patients who are in poor general condition or with complicated empyema. Although several professional associations have recommended vacuum-assisted closure (VAC) as an adjunct to standard treatment, exact data regarding the clinical role of intrathoracic VAC are not available. The primary objective of this study was to determine the safety and efficacy of intrathoracic VAC in debilitated patients and to compare the results with those of previous OWT studies. METHODS We investigated 127 patients with a poor performance status who initially received inpatient intrathoracic VAC for stage II/III empyema thoracis between January 2010 and December 2020. RESULTS The median duration of VAC was 15 days, and the median length of stay was 18 days. Two patients had complications, and the in-hospital mortality rate was 11.8% (15 of 127). Among the 112 surviving patients, 25 (22.3%) were discharged with OWT and 87 (77.7%) were discharged with a closed chest. Empyema recurred in 5 patients. Ultimately, we recorded an absolute success rate of 64.6% (82 of 127). CONCLUSIONS Intrathoracic VAC appears to be safer and associated with less morbidity and mortality than OWT in debilitated patients with empyema. Our results revealed a reduced hospital length of stay and an improved success rate. The results of this work should contribute to improving treatment success in pleural empyema patients.
C1 [Sziklavari, Zsolt; Hammoudeh, Sameer; Petrone, Ana-Maria; Stange, Sebastian; Orban, Karoly] REGIOMED Klinikum, Dept Thorac Surg, Coburg, Germany.
   [Fekete, Janos Tibor] Semmelweis Univ, Dept Bioinformat, Budapest, Hungary.
   [Hofmann, Hans-Stefan] Univ Med Ctr Regensburg, Dept Thorac Surg, Regensburg, Germany.
C3 Semmelweis University; University of Regensburg
RP Sziklavari, Z (通讯作者)，REGIOMED Klinikum Coburg, Dept Thorac Surg, Ketschendorfer Str 33, D-96450 Coburg, Germany.
EM sziklavari_zsolt@yahoo.com
RI Fekete, János Tibor/J-4505-2018; Sziklavari, Zsolt/AGI-2440-2022
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   Towe CW, 2019, J THORAC CARDIOV SUR, V157, P1288, DOI 10.1016/j.jtcvs.2018.10.157
   Tung J, 2019, J TRAUMA ACUTE CARE, V86, P321, DOI 10.1097/TA.0000000000002088
   von Beckerath O, 2017, INT WOUND J, V14, P501, DOI 10.1111/iwj.12635
NR 24
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD JUN
PY 2025
VL 119
IS 6
BP 1206
EP 1212
DI 10.1016/j.athoracsur.2024.08.003
EA JAN 2025
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 3MG9W
UT WOS:001503726000008
PM 39178929
DA 2026-07-24
ER
PT J
AU Daryapeyma, A
   Nilsson, O
   Pettersson, J
   Stackelberg, O
   Torbjörnsson, E
   Hultgren, R
AF Daryapeyma, Alireza
   Nilsson, Olga
   Pettersson, Jennifer
   Stackelberg, Otto
   Torbjornsson, Eva
   Hultgren, Rebecka
TI Prophylactic use of incisional negative pressure wound therapy for groin
   incisions in vascular surgery: randomized clinical trial
SO BJS OPEN
LA English
DT Article
ID SURGICAL SITE INFECTION; LOWER-EXTREMITY REVASCULARIZATION;
   QUALITY-OF-LIFE; RISK-FACTORS; COMPLICATIONS; MULTICENTER; VALIDATION;
   PREVENTION; EXPERIENCE; MANAGEMENT
AB Background: The efficacy of incisional negative pressure wound therapy (iNPWT) in preventing surgical site infections (SSIs) after infrainguinal vascular surgery remains unclear. This study compared iNPWT with standard gauze dressings to determine the effects on SSI incidence and quality of life. Methods: Patients undergoing infrainguinal vascular surgery were recruited to a regional randomized clinical trial. All patients had a groin incision for either thromboendarterectomy only with a vein or synthetic patch or hybrid procedures with thromboendarterectomy and concurrent endovascular treatment. The control and intervention groups received sterile gauze and iNPWT dressings, respectively. The primary endpoint was the incidence of SSIs within 30 days, measured using the Additional treatment, Serous discharge, Erythema, Purulent exudates, Separation of the deep tissues, Isolation of bacteria and inpatient Stay (ASEPSIS) scoring protocol. Secondary endpoints were scores on the Wound Quality of Life and EQ-5D (TM) three-level (EQ-5D-3L (TM)) questionnaires. Results: Of the 123 patients randomized, 109 (89%) completed the study. The incidence of SSI was similar in the intervention and control groups (15% versus 25%, respectively; P = 0.340), but was higher in patients with a body mass index (BMI) >= 25 kg/m2 than in those with a BMI < 25 kg/m2 (52% versus 21%, respectively). Wound Quality of Life mean scores were similar in the control and intervention groups (10.60 versus 12.85, respectively; P = 0.322); however, the intervention group reported a larger negative impact on everyday life than the control group (7.40 versus 4.91 for the everyday life domain, respectively; P = 0.048). There were no significant differences between the two groups in EQ-5D-3L (TM) scores. Conclusion: The similar distribution of SSIs regardless of the type of wound dressing, in addition to the negative impact on everyday life, does not support the general use of iNPWT in this or similar patient cohorts. The unique aspect of this trial is the patient perspective on the use of iNPWT, revealing a divergence between the views of patients and healthcare providers regarding optimal wound care. In the setting of individualized care, there may be a place for iNPWT in selected patients with a high BMI and excessive perioperative bleeding, which are associated with a higher SSI risk.
C1 [Daryapeyma, Alireza; Nilsson, Olga; Hultgren, Rebecka] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Daryapeyma, Alireza; Nilsson, Olga; Hultgren, Rebecka] Karolinska Univ Hosp, Dept Vasc Surg, Stockholm, Sweden.
   [Pettersson, Jennifer] Liljeholmen Univ Primary Hlth Care Ctr, Stockholm, Sweden.
   [Stackelberg, Otto; Torbjornsson, Eva] Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden.
   [Torbjornsson, Eva] Stockholm South Gen Hosp, Dept Surg, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital; Karolinska Institutet; Sodersjukhuset Hospital
RP Hultgren, R (通讯作者)，Karolinska Inst, Karolinska Univ Hosp A8 01, Dept Vasc Surg, S-17176 Stockholm, Sweden.
EM rebecka.hultgren@ki.se
RI Torbjörnsson, Eva/DTM-3611-2022; Hultgren, Rebecka/K-8738-2012; Nilsson,
   Olga/LRT-7525-2024
OI Torbjörnsson, Eva/0000-0003-0720-4981; Stackelberg,
   Otto/0000-0002-5748-9113; Hultgren, Rebecka/0000-0002-8869-0493;
   Nilsson, Olga/0000-0002-7670-1677
FU Swedish Heart-Lung Foundation [20160266, 20220282]; Regional agreement
   on medical training and clinical research [ALF: FoUI-960079]; Stockholm
   County Council; Karolinska Institutet (Hultgren); Capio Research
   Foundation [20193241]
FX This study was supported by the Swedish Heart-Lung Foundation (grant
   numbers 20160266, 20220282), by the Regional agreement on medical
   training and clinical research (ALF: FoUI-960079) between Stockholm
   County Council and Karolinska Institutet (Hultgren) and Capio Research
   Foundation (grant number 20193241). All authors declare independence
   from funders.
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NR 47
TC 3
Z9 4
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD JUN
PY 2025
VL 9
IS 3
AR zraf059
DI 10.1093/bjsopen/zraf059
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3QZ3T
UT WOS:001506926600001
PM 40500745
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zheng, Z
   Yu, HQ
   Liu, L
   Sui, JH
   Hou, YJ
   Chen, MC
   Liu, R
   Meng, XC
   Ding, C
   Zhang, H
AF Zheng, Zhong
   Yu, Huiqi
   Liu, Lu
   Sui, Junhao
   Hou, Yijin
   Chen, Mengchen
   Liu, Rong
   Meng, Xiangchao
   Ding, Chen
   Zhang, Hao
TI Electroactive Dressing Induces Piezoelectric Signals and
   Ca2+ Activation to Enhance Osteoblast
   Differentiation and Bone Regeneration in Negative Pressure Therapy
SO ADVANCED FUNCTIONAL MATERIALS
LA English
DT Article; Early Access
DE bone regeneration; electric field coupling; electroactive dressing;
   electrolyte trapping; negative-pressure wound therapy; open fracture
ID WOUND THERAPY; BIOMATERIALS; SYSTEMS
AB Negative-pressure wound therapy plays a pivotal role in treating open bone fractures. However, the loss of bioelectricity during the healing process significantly delays tissue repair. The generation and maintenance of bioelectric fields require a complex interplay of multiple factors. Previous attempts to regenerate the lost bioelectric field using exogenous conductive materials or supplementing endogenous functional electrolytes have limited success. During this study, a novel electroactive dressing is formulated tailored for negative-pressure therapy by combining piezoelectric poly L-lactic acid doped with bioactive glass and amino-terminated dendritic macromolecules. When subjected to negative pressure, the mechanical deformation of the dressing generates exogenous piezoelectric signals that effectively couple with the endogenous ionic electric fields. Furthermore, the amine-terminated poly(amidoamine) dendritic macromolecules capture cations via coordination and ion-exchange mechanisms, thus retaining electrolytes at the wound site. The findings indicate that the bioelectricity generated by the electroactive dressing under negative pressure facilitates the influx of calcium ions into cells. Calcium ions bind calmodulin, activating Ca-2(+)/calmodulin-dependent kinase II, which further activates phosphatidylinositol3-kinase (PI3K), initiating the PI3K/Akt pathway and enhancing osteoblast activity. The efficacy of the developed electroactive dressing is verified using a critical-sized cranial bone-defect model in rats, demonstrating its significant osteogenic differentiation potential. The exogenous and endogenous fields provided by the electroactive dressing maintain the electrophysiological state necessary for bone regeneration, providing a novel therapeutic approach for clinical open fractures.
C1 [Zheng, Zhong; Liu, Lu; Sui, Junhao; Hou, Yijin; Chen, Mengchen; Ding, Chen; Zhang, Hao] Navy Mil Med Univ, Changhai Hosp, Dept Traumat Orthoped, 168 Changhai Rd, Shanghai 200433, Peoples R China.
   [Yu, Huiqi; Liu, Rong] Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, 516 Jungong Rd, Shanghai 200093, Peoples R China.
   [Meng, Xiangchao] Fudan Univ, Minhang Hosp, Dept Orthoped, 170 Xinsong Rd, Shanghai 201199, Peoples R China.
C3 Naval Medical University; University of Shanghai for Science &
   Technology; Fudan University
RP Ding, C; Zhang, H (通讯作者)，Navy Mil Med Univ, Changhai Hosp, Dept Traumat Orthoped, 168 Changhai Rd, Shanghai 200433, Peoples R China.; Meng, XC (通讯作者)，Fudan Univ, Minhang Hosp, Dept Orthoped, 170 Xinsong Rd, Shanghai 201199, Peoples R China.
EM mengxiangchao@alumni.sjtu.edu.cn; lingtongkong@smmu.edu.cn;
   zhanghsmmu@smmu.edu.cn
RI Meng, Xiangchao/L-3099-2018; Ding, chenzhi/NQF-9844-2025; Zhang,
   Hao/AAK-8111-2020
OI Meng, Xiangchao/0009-0009-6940-6782; Zhang, Hao/0000-0002-6347-2764
FU Science and Technology Innovation Plan Of Shanghai Science and
   Technology Commission [81872171]; National Natural Science Foundation of
   China [22S31900400]; Shanghai Science and Technology Innovation Action
   Plan [2023MHPY01]; Youth Program of Minhang Hospital [2025MWTZA04];
   Shanghai Minhang District Medical Specialty Construction Project
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 81702666), the National Natural Science Foundation of
   China (Grant No. 81872171), the Shanghai Science and Technology
   Innovation Action Plan (Grant No. 22S31900400), the Youth Program of
   Minhang Hospital (2023MHPY01), and Shanghai Minhang District Medical
   Specialty Construction Project (2025MWTZA04).
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NR 50
TC 7
Z9 7
U1 24
U2 61
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1616-301X
EI 1616-3028
J9 ADV FUNCT MATER
JI Adv. Funct. Mater.
PD 2025 JUN 9
PY 2025
DI 10.1002/adfm.202507082
EA JUN 2025
PG 20
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
   Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
   Physics, Condensed Matter
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA 3TA5H
UT WOS:001508311500001
DA 2026-07-24
ER
PT J
AU Arundel, C
   Mandefield, L
   Fairhurst, C
   Baird, K
   Gkekas, A
   Saramago, P
   Chetter, I
AF Arundel, Catherine
   Mandefield, Laura
   Fairhurst, Caroline
   Baird, Kalpita
   Gkekas, Athanasios
   Saramago, Pedro
   Chetter, Ian
CA SWHSI 2 Trial Investigators
TI Negative pressure wound therapy versus usual care in patients with
   surgical wound healing by secondary intention in the UK (SWHSI-2): an
   open-label, multicentre, parallel-group, randomised controlled trial
SO LANCET
LA English
DT Article
ID ALGINATE; CLOSURE
AB Background Surgical wound healing by secondary intention (SWHSI) presents a substantial management and financial challenge. Negative pressure wound therapy (NPWT) has increasingly been used as a treatment despite an absence of comparative evidence of effectiveness. We evaluated the effectiveness of NPWT compared with usual care for improving time to wound healing in patients with an SWHSI. Methods We did a pragmatic, open-label, multicentre, parallel-group, randomised controlled trial in 29 UK National Health Service Trusts. Participants aged 16 years or older with an SWHSI appropriate for both study treatments (NPWT or usual care) were randomly assigned (1:1) by a centralised web-based system. Randomisation was stratified by wound location, wound area, and study centre. Participants were followed up for 12 months. Participants and clinical and research teams could not be masked to treatment. Assessors masked to treatment reviewed wound photography to verify the outcome. The primary outcome was time to wound healing (days from randomisation to complete epithelial cover), analysed via intention to treat using Kaplan-Meier survival curves and a proportional hazards Cox regression model. The trial was registered with ISRCTN, ISRCTN26277546. Findings Between May 15, 2019, and Jan 13, 2023, 686 participants with an SWHSI were randomly assigned to receive NPWT (n=349) or usual care (n=337). All participants were included in the primary analysis. Most participants were diabetic (n=549, 80<middle dot>0%) and had a single SWHSI (n=622, 90<middle dot>7%), located on the foot or leg (n=620, 90<middle dot>4%), arising after vascular surgery (n=619, 90<middle dot>2%). There was no clear evidence that NPWT reduced the time to wound healing compared with usual care (hazard ratio 1<middle dot>08 [95% CI 0<middle dot>88-1<middle dot>32], p=0<middle dot>47). There were 448 adverse events, of which 14 were serious (nine participants in the NPWT group and five participants in the usual care group); 124 were deemed potentially related to treatment. NPWT was found not to be cost-effective compared with usual care. Interpretation In patients with a lower limb SWHSI, including those with complications of diabetes, there is no clear evidence that NPWT reduced the time to wound healing compared with standard dressings. These findings do not support the use of NPWT to augment SWHSI healing.
C1 [Arundel, Catherine; Mandefield, Laura; Fairhurst, Caroline; Baird, Kalpita; Gkekas, Athanasios] Univ York, York Trials Unit, York YO10 5DD, England.
   [Saramago, Pedro] Ctr Hlth Econ, York, England.
   [Saramago, Pedro] Univ York, York, England.
   [Chetter, Ian] Univ Hull, Fac Hlth Sci, Kingston Upon Hull, England.
   [Chetter, Ian] Hull York Med Sch, Kingston Upon Hull, England.
   [Chetter, Ian] Hull Univ Teaching Hosp NHSTrust, Kingston Upon Hull, England.
C3 University of York - UK; University of York - UK; University of York -
   UK; University of Hull; University of Hull; University of York - UK
RP Arundel, C (通讯作者)，Univ York, York Trials Unit, York YO10 5DD, England.
EM catherine.arundel@york.ac.uk
OI Mandefield, Laura/0000-0002-4219-5673; chetter, ian/0000-0002-2566-6859;
   Gkekas, Athanasios/0000-0003-4357-9043
FU National Institute for Health Research Health Technology Assessment
   Programme
FX National Institute for Health Research Health Technology Assessment
   Programme.
CR 3M, 3M Negative Pressure Wound Therapy (NPWT)
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NR 28
TC 20
Z9 24
U1 3
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD MAY 10
PY 2025
VL 405
IS 10490
BP 1689
EP 1699
DI 10.1016/S0140-6736(25)00143-6
EA JAN 2025
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3UC3R
UT WOS:001509043200022
PM 40250455
OA Green Accepted, Green Published, Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Xing, H
   Pan, JL
   Liu, H
   Wang, YN
   Chang, ZQ
AF Xing, Hao
   Pan, Junlin
   Liu, Huan
   Wang, Yanan
   Chang, Zhengqi
TI Preliminary research indicates that mechanical force through Pioze1
   enhances local immunity during NPWT treatment for spinal infections
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE spinal infection; negative pressure wound therapy; Piezo1; mechanical
   force; immune response
ID PRESSURE WOUND THERAPY; PYOGENIC SPONDYLODISCITIS
AB Objective This study aims to investigate the mechanism by which Negative Pressure Wound Therapy (NPWT) regulates local immune responses in spinal infection through Piezo1-mediated mechanical stress, and elucidate its potential role in the treatment of spinal infections. Methods From July 2021 to April 2022, a total of 7 patients with spinal infection treated with NPWT at our department were included in the study. The study analyzed clinical outcomes of spinal infection surgeries, including operative duration, intraoperative blood loss, postoperative drainage, improvements in pain levels as measured by the Visual Analogue Scale (VAS), and inflammatory markers such as C-reactive protein (CRP) and Erythrocyte Sedimentation Rate (ESR) measured one week before and after the procedure. Additionally, healing times and recurrence rates within two years post-surgery were assessed. In addition, lesion specimens were retained during surgery and changes in Piezo1, Interleukin-1 beta (IL-1 beta), IL-6, IL-8, and Tumor Necrosis Factor-alpha (TNF-alpha) in lesion tissues were observed before and after immunohistochemical analysis. Results All 7 patients with spinal infections successfully underwent NPWT treatment and were ultimately cured. The average healing time was 45.71 +/- 9.49 days, and there were no cases of recurrence or death during the two-year follow-up period. Surgical data showed a surgery duration of 96.57 +/- 13.31 minutes, intraoperative blood loss of 65.71 +/- 29.36 milliliters, and postoperative drainage of 163.57 +/- 11.07 milliliters. Postoperatively, CRP, ESR, and VAS all significantly improved compared to preoperative levels (all p<0.05), which was superior to traditional treatment methods. Following NPWT intervention, the expression of Piezo1 protein at the lesion site significantly increased (0.03 +/- 0.11 vs. 0.27 +/- 0.22; p<0.05), while the expression levels of IL-1 beta, IL-6, IL-8, and TNF-alpha in the local immune microenvironment of the infected lesion significantly decreased (0.26 +/- 0.11 vs. 0.16 +/- 0.09, 0.27 +/- 0.12 vs. 0.15 +/- 0.67, 0.26 +/- 0.18 vs. 0.10 +/- 0.12, 0.35 +/- 0.21 vs. 0.15 +/- 0.11; p<0.05). Conclusion Clinical results demonstrate that NPWT treatment for spinal infections exhibits remarkable efficacy, accompanied by a notable augmentation in local Piezo1 protein consistency. It is hypothesized that the mechanical force employed in NPWT treatment stimulates the Piezo1 protein, thereby modulating local immune cells and factors, ultimately bolstering local immunity. This study not only provides a molecular biology basis for a deeper understanding of the therapeutic effects of NPWT, but also offers new insights for optimizing treatment strategies for spinal infections.
C1 [Xing, Hao; Liu, Huan; Wang, Yanan; Chang, Zhengqi] 960th Hosp Peoples Liberat Army China PLA, Dept Orthopaed, Jinan, Peoples R China.
   [Pan, Junlin] 960th Hosp Peoples Liberat Army China PLA, Dept Reprod Med, Jinan, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp Peoples Liberat Army China PLA, Dept Orthopaed, Jinan, Peoples R China.
EM 26766771@qq.com
RI hao, xing/ACN-7926-2022
FU Natural Science Foundation of Shandong Province [ZR2023MH331]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This research was supported
   by Natural Science Foundation of Shandong Province (Award Number:
   ZR2023MH331; Grant Recipient: Zhengqi Chang).
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NR 38
TC 2
Z9 2
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JUN 3
PY 2025
VL 16
AR 1600194
DI 10.3389/fimmu.2025.1600194
PG 7
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 3UH0L
UT WOS:001509165900001
PM 40529353
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jin, L
   Niu, C
   Ni, YL
AF Jin, Liang
   Niu, Chao
   Ni, Yulong
TI Effect of vacuum sealing drainage combined with alprostadil and lipoic
   acid in the treatment of diabetic foot ulcer and its effect on
   inflammatory factors
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article; Early Access
DE Diabetic foot ulcer; Vacuum sealing drainage; Alprostadil; Lipoic acid;
   Efficacy; Inflammatory factor
ID PERIPHERAL NEUROPATHY; THERAPY; ALPHA; COMBINATION; EFFICACY; VELOCITY
AB Background Diabetic foot ulcer (DFU) is one of the most common complications in diabetic patients. In recent years, vacuum sealing drainage (VSD) therapy has been widely applied in clinical wound healing, effectively promoting wound healing and reducing the occurrence of infections. However, VSD therapy can only locally improve the wound microenvironment and is insufficient in regulating systemic inflammatory responses. Alprostadil, a prostaglandin, has shown certain effectiveness in the treatment of DFU by improving microcirculation and promoting blood flow. Lipoic acid, a potent antioxidant, can alleviate oxidative stress, improve metabolic abnormalities, and reduce inflammatory responses in diabetic patients, thereby promoting wound healing. The combined use of VSD, alprostadil, and lipoic acid may have a synergistic effect in the treatment of DFU. Objective This study conducts a retrospective analysis of clinical data from diabetic foot ulcer (DFU) patients treated at our institution to investigate the therapeutic efficacy of vacuum sealing drainage (VSD) combined with alprostadil and lipoic acid in treating DFUs, and its impact on inflammatory factors in patients. Methods A retrospective analysis was conducted on the clinical data of 98 patients diagnosed with DFU who were admitted to our hospital between January 2022 and February 2023. Based on their respective treatment protocols, the patients were categorized into two groups: the control group (n = 52) and the observation group (n = 46). All patients enrolled in the study underwent VSD treatment, with the observation group receiving additional alprostadil and lipoic acid supplementation. The therapeutic efficacy was evaluated for all participants 2 weeks after treatment initiation, and the wound healing time, the time of stopping using VSD and its hospitalization time, hospitalization expenses, and adverse reactions of the two groups were recorded. Furthermore, analyses included pre- and post-treatment assessments of growth factor levels in granulation tissue, alongside evaluations of fibrotic activity markers, oxidative stress indicators, inflammatory cytokine profiles, and arterial hemodynamics in both groups. Results. Results The observation group demonstrated a significantly higher effective rate of 93.48% (43/46) compared to 76.92% (40/52) in the control group, and the wound healing time of observer was lower than that of control group (p < 0.05). Post-treatment, levels of VEGF and PDGF in granulation tissue increased in both groups relative to pre-treatment levels, with higher levels observed in the observation group compared to the control group (p < 0.05). Post-treatment, levels of tPA, SOD, GSH-PX, CAT, blood flow velocity, vessel inner diameter, RI, and PI in both groups were higher than pre-treatment levels, while levels of FPA, PAI-1, CRP, IL-6, Hcy, and TNF-alpha were lower than pre-treatment levels. Additionally, the observation group exhibited higher levels of tPA, SOD, GSH-PX, CAT, blood flow velocity, vessel inner diameter, RI, and PI compared to the control group and lower levels of FPA, PAI-1, CRP, IL-6, Hcy, and TNF-alpha compared to the control group (p < 0.05). The time to stop using VSD, hospitalization time, and hospitalization expenses in the observation group was lower than those in the control group (p < 0.05).
   Conclusion The treatment of DFU with VSD combined with alprostadil and lipoic acid can significantly promote wound healing and granulation growth, shorten wound healing time, effectively enhance cellulase activity and antioxidant capacity of patients, relieve inflammation, and protect vascular endothelial cells, with high efficiency and safety, and effectively reduce the use time of VSD and the hospitalization time and expenses of patients, which is worthy of promotion.
C1 [Jin, Liang; Niu, Chao; Ni, Yulong] Xingtai Peoples Hosp, Dept Hand & Foot Surg, Xingtai 054000, Hebei, Peoples R China.
RP Jin, L (通讯作者)，Xingtai Peoples Hosp, Dept Hand & Foot Surg, Xingtai 054000, Hebei, Peoples R China.
EM jl00981009@163.com
FU Medical Science Research Project Plan of Hebei Province 2021 [20210053]
FX This study was supported by Medical Science Research Project Plan of
   Hebei Province 2021(20210053).
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NR 39
TC 0
Z9 0
U1 0
U2 5
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD 2025 JUN 10
PY 2025
DI 10.1007/s13410-025-01504-y
EA JUN 2025
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3UQ4I
UT WOS:001509411400001
DA 2026-07-24
ER
PT J
AU Vélez-Palafox, M
   Ponce-Damián, LD
   Márquez-Gutiérrez, EA
   González-Torres, M
AF Velez-Palafox, Mario
   Ponce-Damian, Leonardo David
   Marquez-Gutierrez, Erik Agustin
   Gonzalez-Torres, Maykel
TI Neck reconstruction in burn sequelae: A comparison of full-thickness
   skin grafts with traditional tie-over versus negative pressure wound
   therapy for both recipient site preparation and graft fixation
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Burn sequelae; Full-thickness graft; Negative wound therapy; Neck
   reconstruction
ID HEAD; DRESSINGS; EFFICACY
AB Background: Neck reconstruction for burn sequelae can be effectively achieved through release procedures and lower abdomen skin transplantation. This article describes cases in which full-thickness skin grafts (FTSGs) from the lower abdomen were used as donor areas. Although the benefits of negative pressure wound therapy (NPWT) for graft integration are known, its dual use for recipient site preparation and intraoperative graft fixation, specifically in the neck, has been scarcely described. This study evaluates both applications of NPWT-preoperative wound bed optimization and intraoperative graft fixation-highlighting their combined impact on graft take and patient outcomes. Methods: Patients treated at a referral burn center between March 2021 and October 2023 with severe neck contractures underwent scar release and FTSG transplantation. Two techniques for graft fixation were compared: the traditional tie-over method and NPWT. Graft integration rates, necrosis percentages, and postoperative complications were assessed. Results: The study included six patients (tie-over group: 2; NPWT group: 4). The NPWT group demonstrated clinically favorable graft integration rates (92.5 %) and lower necrosis rates (7.5 %) compared with the tie-over group (76.5 % and 23.5 %, respectively). The NPWT technique also resulted in shorter hospital stays and fewer complications. Conclusions: The combined use of NPWT for recipient site preparation and intraoperative graft fixation clinically improves graft integration and reduces complications in neck burn reconstruction. These findings suggest that NPWT should be considered a standard of care in settings where resources allow.
C1 [Velez-Palafox, Mario] Natl Inst Rehabil, Natl Ctr Res & Care Burns, Div Head Plast & Reconstruct Surg, Mexico City, Mexico.
   [Velez-Palafox, Mario] Univ Nacl Autonoma Mexico, Fac Med, Grad Studies Div, Mexico City, Mexico.
   [Ponce-Damian, Leonardo David; Marquez-Gutierrez, Erik Agustin] Natl Ctr Res & Care Burns, Natl Inst Rehabil, Div Plast & Reconstruct Surg, Mexico City, Mexico.
   [Gonzalez-Torres, Maykel] UNAM, Fac Estudios Super Cuautitlan, Dept Ciencias Quim, Ave 1ro Mayo S-N, Cuautitlan 54740, Estado De Mexic, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico
RP Vélez-Palafox, M (通讯作者)，Univ Nacl Autonoma Mexico, Fac Med, Grad Studies Div, Mexico City, Mexico.
EM mariovelez@hotmail.com; maykel.gonzalez@conahcyt.mx
RI ; González Torres, Maykel/O-4924-2019
OI MÁRQUEZ-GUTIÉRREZ, ERIK/0009-0004-1651-0256; Velez-Palafox,
   Mario/0009-0009-4275-7590; González Torres, Maykel/0000-0003-3899-4410
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NR 30
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD MAY
PY 2025
VL 56
IS 5
AR 112323
DI 10.1016/j.injury.2025.112323
EA MAY 2025
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 3VA8K
UT WOS:001509684400001
PM 40222842
OA hybrid
DA 2026-07-24
ER
PT J
AU Deng, YX
   Wang, XC
   Xia, ZY
   Wan, MY
   Jiang, DY
AF Deng, Yun-Xiang
   Wang, Xiao-Chuan
   Xia, Zhen-Yu
   Wan, Meng-Ya
   Jiang, Du-Yin
TI Efficacy and safety of negative pressure wound therapy for the treatment
   of diabetic foot ulcers: A meta-analysis
SO WORLD JOURNAL OF DIABETES
LA English
DT Article
DE Negative pressure wound therapy; Diabetic foot ulcer; Wound healing;
   Amputation; Adverse events; Meta-analysis
ID VACUUM-ASSISTED CLOSURE; MULTICENTER
AB BACKGROUND Diabetic foot ulcers (DFUs) are a significant challenge in diabetic care, and the efficacy of negative pressure wound therapy (NPWT) in treating them remains a subject of continuous investigation. AIM To provide a comprehensive meta-analysis of the role of NPWT in the management of DFUs. METHODS A systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, searching databases like PubMed, Embase, Web of Science, and the Cochrane Library. Randomized clinical trials (RCTs) were included to compare NPWT to other dressings for DFUs. Outcomes measured were wound healing time and rate, granulation tissue formation time, amputation rate, and adverse events. Study quality was evaluated using Cochrane's risk of bias tool. Analyses utilized chi 2, I2, fixed or random-effects models via Stata v17. RESULTS Of the 1101 identified articles, 9 RCTs were selected for meta-analysis. Studies spanned from 2005 to 2020 and originated from countries including the United States, Chile, Pakistan, Italy, India, and Germany. Meta-analysis demonstrated a significant improvement in wound healing rate [risk ratio (RR) = 1.46, 95%CI: 1.22-1.76, P < 0.01] and a reduction in amputation rate (RR = 0.69, 95%CI: 0.50-0.96, P = 0.006) with NPWT. Furthermore, the time for granulation tissue formation was significantly reduced by an average of 19.54 days. However, the incidence of adverse events did not significantly differ between NPWT and control treatments. CONCLUSION NPWT significantly improves wound healing rates and reduces amputation rates in DFUs. It also hastens the formation of granulation tissue. However, the therapy does not significantly alter the risk of adverse events compared to alternate treatments.
C1 [Deng, Yun-Xiang; Xia, Zhen-Yu; Wan, Meng-Ya] Shandong Univ, Cheeloo Coll Med, Jinan 250012, Shandong, Peoples R China.
   [Wang, Xiao-Chuan] Second Hosp Shandong Univ, Dept Plast Surg & Burns, Jinan 250033, Shandong, Peoples R China.
   [Jiang, Du-Yin] Second Hosp Shandong Univ, Emergency Med Ctr, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China.
C3 Shandong University; Shandong University; Shandong University
RP Jiang, DY (通讯作者)，Second Hosp Shandong Univ, Emergency Med Ctr, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China.
EM duyinjiang0227@yeah.net
FU National Natural Science Foundation of China [82202454, 81873934]; Wang
   Zhengguo Trauma Medicine Fund [SZYZ-TR-09]; Shandong Provincial Natural
   Science Foundation Youth Fund [ZR2020QH168]; Jinan Science and
   Technology Plan Project [202225065]
FX Supported by the National Natural Science Foundation of China, No.
   82202454 and No. 81873934; the Wang Zhengguo Trauma Medicine Fund
   (Growth Factor Revival Plan) No. SZYZ-TR-09; the Shandong Provincial
   Natural Science Foundation Youth Fund, No. ZR2020QH168; and the Jinan
   Science and Technology Plan Project, No. 202225065.
CR Akkus G, 2022, WORLD J DIABETES, V13, P1106, DOI 10.4239/wjd.v13.i12.1106
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NR 28
TC 5
Z9 6
U1 1
U2 7
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JUN 15
PY 2025
VL 16
IS 6
AR 103520
DI 10.4239/wjd.v16.i6.103520
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3VM7K
UT WOS:001509994900024
PM 40548270
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Zhang, HW
   Lu, WF
AF Zhang, Huiwen
   Lu, Weifeng
TI Successful treatment with decompressive laparotomy for abdominal
   compartment syndrome induced by asparaginase-associated pancreatitis in
   a pediatric patient with acute lymphoblastic leukemia: a case report
SO TRANSLATIONAL PEDIATRICS
LA English
DT Article
DE Acute lymphoblastic leukemia (ALL); asparaginase-associated pancreatitis
   (AAP); abdominal compartment syndrome (ACS); decompressive laparotomy
   (DL); case report
ID PERSISTENT INFLAMMATION-IMMUNOSUPPRESSION; INTRAABDOMINAL HYPERTENSION;
   DEFINITIONS; CONSENSUS
AB Background: Asparaginase (ASP) has significantly improved the complete remission rate and long-term event-free survival in children with acute lymphoblastic leukemia (ALL). Asparaginase-associated pancreatitis (AAP) is a potentially toxic side effect of ASP, which may even lead to fatal abdominal compartment syndrome (ACS) in extreme cases. Currently, there is no consensus on the indications for decompressive laparotomy (DL), including when to initiate it, what criteria to use for decision-making, or how to perform the procedure. Moreover, available research data remain limited. Case Description: We present a case of a 2-year-old boy with ALL who developed ACS, a fatal complication of severe acute pancreatitis (SAP) following treatment with pegaspargase (PEG-ASP). Massive transfusion stabilized his hemodynamics and intraluminal contents were evacuated, yet his symptoms progressed. Consequently, the patient underwent DL and continuous venovenous hemodiafiltration (CVVHDF) with ultrafiltrati on. Postoperative complications including enteroatmospheric fistulas and abdominal abscesses were gradually corrected by negative-pressure wound therapy (NPWT). The boy was discharged from the intensive care unit (ICU) on the 93rd day after hospital admission. During followup, the child's abdominal symptoms gradually improved, and bridging therapy with blinatumomab was administered. Conclusions: In this case, a pediatric ALL patient developed life-threatening complications following PEG-ASP administration, which were ultimately successfully managed through multidisciplinary intervention. When pediatric hematology-oncology patients develop ACS, clinicians should carefully evaluate the oncological context and thoroughly assess the risks of surgical versus conservative management for this potentially fatal condition. Optimal timing of surgical intervention combined with advanced perioperative care is critical for achieving favorable outcomes. We strongly recommend conducting highquality clinical research to establish evidence-based treatment guidelines.
C1 [Zhang, Huiwen; Lu, Weifeng] Nanjing Med Univ, Childrens Hosp, Dept Surg Intens Care Unit, 72 Guangzhou Rd, Nanjing 210008, Peoples R China.
C3 Nanjing Medical University
RP Lu, WF (通讯作者)，Nanjing Med Univ, Childrens Hosp, Dept Surg Intens Care Unit, 72 Guangzhou Rd, Nanjing 210008, Peoples R China.
EM luweifengmm@163.com
CR Bade NA, 2020, J ONCOL PHARM PRACT, V26, P74, DOI 10.1177/1078155219838316
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NR 23
TC 0
Z9 1
U1 0
U2 0
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-4336
EI 2224-4344
J9 TRANSL PEDIATR
JI Transl. Pediatr.
PD MAY
PY 2025
VL 14
IS 5
BP 1050
EP 1058
DI 10.21037/tp-24-440
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 3YA3D
UT WOS:001511713000025
PM 40519724
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gratteri, M
   Luciano, C
   Romano, FD
   Abate, L
   Mirra, C
   Savani, L
   Papalia, GF
   Papalia, R
   Farsetti, P
   Marangi, GF
   Persichetti, P
AF Gratteri, Marco
   Luciano, Claudia
   Romano, Fara Desiree
   Abate, Luigi
   Mirra, Carlo
   Savani, Luca
   Papalia, Giuseppe Francesco
   Papalia, Rocco
   Farsetti, Pasquale
   Marangi, Giovanni Francesco
   Persichetti, Paolo
TI Negative Pressure Wound Therapy for Management of Achilles Region
   Defects: A Systematic Review of the Literature
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE Achilles tendon; NPWT; negative pressure; negative pressure wound
   therapy; skin graft; flap; Achilles tendon; NPWT; negative pressure;
   Achilles tendon; negative pressure wound therapy; NPWT; skin graft;
   negative pressure; flap; negative pressure wound therapy; skin graft;
   flap
ID SOFT-TISSUE DEFECTS; TENDON RUPTURES; SKIN
AB Background. Despite the efforts of plastic and orthopedic surgeons to elaborate the most appropriate treatment for lesions of the Achilles region and their reconstruction, no universal guideline exists. Regenerative treatments such as negative pressure wound therapy (NPWT) are increasingly being used in the management of these defects. Objective. To research the different usage protocols, roles, and outcomes of NPWT in the management and reconstruction of Achilles region defects. Methods. A scientific literature search was performed by querying Medline and Scopus using the terms "(Achilles tendon) AND ((vac) OR (vacuum assisted closure) OR (negative pressure) OR (NPWT))." The authors used an online screening software. The investigation followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement for systematic review. Results. Of the initial 153 studies identified, only 14 fulfilled the eligibility criteria and were included in this review. Analyzed protocols mainly included surgical debridement combined with the use of NPWT as a primary dressing directly on the tendon or as a secondary dressing covering a splitthickness skin graft (STSG) or a flap. Additionally, the combination of negative pressure with matrices was found to provide optimal results even after STSG failure. Most of the reported complications described in the included studies involved partial loss of graft or flap. Conclusion. NPWT can be used either as a primary dressing (directly on the lesion) or as a secondary dressing (over a flap or a skin graft) for management of Achilles region defects. The combined use of negative pressure with matrices can also aid in wound reduction.
C1 [Gratteri, Marco; Romano, Fara Desiree; Abate, Luigi; Mirra, Carlo; Savani, Luca; Marangi, Giovanni Francesco; Persichetti, Paolo] Campus Biomed Univ Rome, Dept Plast Reconstruct & Aesthet Surg, Via Alvaro Del Portillo 200, I-00128 Rome, Italy.
   [Luciano, Claudia; Farsetti, Pasquale] Univ Roma Tor Vergata, Dept Clin Sci & Translat Med, Sect Orthopaed & Traumatol, Rome, Italy.
   [Papalia, Giuseppe Francesco; Papalia, Rocco] Campus Biomed Univ Rome, Dept Orthopaed & Trauma Surg, Rome, Italy.
C3 University Campus Bio-Medico - Rome Italy; University of Rome Tor
   Vergata; University Campus Bio-Medico - Rome Italy
RP Romano, FD (通讯作者)，Campus Biomed Univ Rome, Dept Plast Reconstruct & Aesthet Surg, Via Alvaro Del Portillo 200, I-00128 Rome, Italy.
EM faradesiree.romano@unicampus.it
RI Papalia, Rocco/I-9192-2014; Papalia, Giuseppe Francesco/ACO-2068-2022;
   Gratteri, Marco/KGM-5481-2024; Marangi, Giovanni/AAW-4723-2020
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NR 50
TC 0
Z9 0
U1 1
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2025
VL 37
IS 5
BP 186
EP 197
DI 10.25270/wnds/24180
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 3YC6O
UT WOS:001511774400003
PM 40512681
DA 2026-07-24
ER
PT J
AU Greeny, A
   Shenoy, RR
AF Greeny, Alosh
   Shenoy, Rekha R.
TI Advances in Burn Wound Management: Innovative Strategies for Healing and
   Infection Control
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE nanotherapeutics; hydrogels; stem cell therapy; negative pressure wound
   therapy; burn wound; acellular fish skin
ID VACUUM-ASSISTED CLOSURE; MESENCHYMAL STEM-CELLS; FISH-SKIN-GRAFT; SILVER
   SULFADIAZINE; DRUG-DELIVERY; KELOID FIBROBLASTS; POLYVINYL-ALCOHOL;
   PRESSURE THERAPY; EDEMA FORMATION; HEALTH-CARE
AB Burn wounds are insults to the skin that can be caused by various sources, including thermal, electrical, or chemical sources, and even natural sources such as the sun. A burn wound is conventionally categorized into 3 distinct zones: (1) coagulation, (2) ischemia/stasis, and (3) hyperemia. In addition to the potential for physiological scarring, burn wounds can lead to microbial infections, such as pneumonia and methicillin-resistant Staphylococcus aureus, that are difficult to treat using conventional antimicrobial therapy. Patients whose burn wounds trigger a systemic inflammatory response experience further deterioration of their medical condition. Moreover, an increase in the incidence of antibiotic resistance poses a major challenge in the treatment of wounds. Researchers are shifting their focus to newer techniques, such as acellular fish skin, hydrogels, negative pressure wound therapy, nanotherapeutics, and stem cell therapy to counter the disadvantages associated with conventional therapy. This review provides an overview of burn wound causes, classifications, and treatments, and it discusses the healing phases of wounds, possible types of infections, the complexities associated with existing conventional treatments, and the advanced techniques currently used in burn wound management that have proven to reduce hospital stays and make treatment more cost-effective.
C1 [Greeny, Alosh; Shenoy, Rekha R.] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
C3 Manipal Academy of Higher Education (MAHE)
RP Shenoy, RR (通讯作者)，Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
EM rekha.shenoy@manipal.edu
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NR 147
TC 6
Z9 6
U1 5
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2025
VL 37
IS 5
BP 198
EP 209
DI 10.25270/wnds/24030
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 3YC6O
UT WOS:001511774400004
PM 40512682
DA 2026-07-24
ER
PT J
AU Tseng, YL
   Wu, HS
   Huang, PY
   Hsaio, PS
   Tseng, HC
AF Tseng, Yi-Ling
   Wu, Hua-Shan
   Huang, Pei-Yu
   Hsaio, Pei-Shan
   Tseng, Hui-Chen
TI Effects of a Situated Simulation Teaching Strategy on Knowledge of
   Negative-Pressure Wound Therapy among Surgical Nurses in Taiwan
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE education; educational training; knowledge; negative-pressure wound
   therapy; situated simulation teaching; surgical nurse; wound care
ID RISK-FACTORS; EDUCATION; COMPLICATIONS; REFLECTION; OUTCOMES
AB OBJECTIVE: To evaluate the effect of a situated simulation teaching strategy for negative-pressure wound therapy (NPWT) on surgical nurses' knowledge of care for patients who receive NPWT. METHODS: This quasi-experimental study used a one-group pretest/posttest design. Thirty-one female surgical nurses from a central Taiwan district hospital participated. They received situational simulation training and completed self-administered preintervention and postintervention scale assessing their knowledge of NPWT-related care and a demographic questionnaire RESULTS: Participants' mean score on the knowledge of NPWT-related care scale was 19.90 preintervention and increased to 27.84 postintervention, a significant improvement (z = -4.45, P < .001). All aspects of NPWT knowledge, including indications and effects (z = -3.84, P < .001), device operation (z = -3.71, P < .001), assessment (z = -3.89, P < .001), and anomaly response (z = -3.93, P < .001), significantly improved following the intervention. CONCLUSIONS: The study indicates that simulation and cues and a debriefing session in situational simulation teaching significantly enhance surgical nurses' knowledge of NPWT-related care and facilitates the acquisition of problem-solving methods, suggesting its potential application in NPWT-related continuing education courses for surgical nurses.
C1 [Tseng, Yi-Ling] Tunghai Univ, Coll Agr & Hlth, Bachelor Sci Sr Wellness & Sports Sci, Taichung, Taichung County, Taiwan.
   [Wu, Hua-Shan] Asia Univ, Dept Nursing, Taichung, Taichung County, Taiwan.
   [Huang, Pei-Yu] Jen Ai Hosp, Dementia Ctr, Taichung, Taiwan.
   [Hsaio, Pei-Shan] Asia Univ Hosp, Taichung, Taiwan.
   [Tseng, Hui-Chen] Kaohsiung Med Univ, Coll Nursing, Kaohsiung, Taiwan.
   [Tseng, Hui-Chen] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan.
C3 Tunghai University; Asia University Taiwan; Kaohsiung Medical
   University; Kaohsiung Medical University; Kaohsiung Medical University
   Hospital
RP Tseng, YL (通讯作者)，Tunghai Univ, Coll Agr & Hlth, Bachelor Sci Sr Wellness & Sports Sci, Taichung, Taichung County, Taiwan.
EM elin627@yahoo.com.tw; huashan64@gmail.com; aegis22303@gmail.com;
   scorpio821031@gmail.com; huchts@kmu.edu.tw
RI ; Tseng, Hui-Chen/ABD-4738-2021
OI Tseng, Yi-Ling/0000-0002-2926-7177; Tseng, Hui-Chen/0000-0001-9621-7316
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NR 41
TC 1
Z9 1
U1 3
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUL
PY 2025
VL 38
IS 6
BP 303
EP 309
DI 10.1097/ASW.0000000000000293
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 3YX6K
UT WOS:001512320900002
PM 40184506
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Herold, JM
   Selkridge, I
   Nocon, AA
   Bornes, TD
   Sculco, TP
   Carli, AV
   Sculco, PK
AF Herold, Johannes M.
   Selkridge, Isaiah
   Nocon, Allina A.
   Bornes, Troy D.
   Sculco, Thomas P.
   Carli, Alberto V.
   Sculco, Peter K.
TI Closed-Incision Negative Pressure Wound Therapy Improves Outcomes in
   Obese Aseptic Revision Total Hip and Knee Arthroplasty
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE aseptic revision; revision total knee arthroplasty; revision total hip
   arthroplasty; closed-incision negative pressure wound therapy; high-risk
   patients; obese patients; obese patients
ID TOTAL JOINT ARTHROPLASTY; VACUUM-ASSISTED CLOSURE; HOSPITAL READMISSION;
   UNITED-STATES; RISK-FACTORS; INFECTION; MORBIDITY; SURGERY;
   COMPLICATIONS; PROJECTIONS
AB Background: The burden of revision total joint arthroplasty (rTJA) is increasing. Revision procedures are associated with an increased risk of perioperative complications. Obese patients undergoing rTJA may have a higher risk of wound complications due to their soft-tissue envelope. Closed-incision negative pressure wound therapy (ciNPWT) has been rigorously investigated for its effect on reducing wound complications; however, the literature is limited to primary total joint arthroplasty. The purpose of the current study was to investigate the association between ciNPWT and clinical outcomes for obese patients undergoing aseptic revision total hip and knee arthroplasty. Methods: This was a retrospective study examining aseptic rTJA procedures from January 2017 to December 2021 at a high-volume institution. Patients were included if their body mass index was > 35 and had a minimum follow-up of 2 years. The cohorts were rTJA procedures that used ciNPWT versus procedures without ciNPWT use. A total of 214 rTJA (Hip, n = 61; Knee, n = 153) patients qualified for analysis. After surgery, ciNPWT was applied on 130 (60.7%) patients (92 knees and 38 hips), and standard dressing was used on 84 (39.3%) patients (61 knees and 23 hips). There were no significant baseline differences between the groups. Outcomes evaluated were as follows: (1) revision for infection; (2) superficial wound complications; (3) overall complications; (4) all-cause revision; and (5) all-cause readmissions. The association between ciNPWT use and outcomes was evaluated using Chi-square tests. Results: When controlling for all variables, ciNPWT use was associated with significantly fewer revisions for infection (0.8 versus 8.3%), overall complications (3.8 versus 11.9%), all-cause revisions (3.1 versus 13.1%), and readmissions (10.8 versus 21.7%) compared to those who did not use ciNPWT. Secondary superficial wound complication-specific outcomes did not show significant differences. Conclusions: To our knowledge, this study is the largest retrospective study to date examining the effect of ciNPWT on outcomes in obese aseptic revision rTJA patients. Our results demonstrated major benefits associated with the use of ciNPWT in obese patients undergoing aseptic rTJA in reference to infectionrelated revision, overall complications, all-cause revisions, and early readmission for any reason. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Herold, Johannes M.; Selkridge, Isaiah; Nocon, Allina A.; Bornes, Troy D.; Sculco, Thomas P.; Carli, Alberto V.; Sculco, Peter K.] Hosp Special Surg, Stavros Niarchos Fdn Complex Joint Reconstruct Ctr, New York, NY USA.
   [Nocon, Allina A.; Sculco, Thomas P.; Carli, Alberto V.; Sculco, Peter K.] Hosp Special Surg, Dept Orthoped Surg, Adult Reconstruct & Joint Replacement Serv, New York, NY USA.
   [Bornes, Troy D.] Univ Alberta, Royal Alexandra Hosp, Div Orthopaed Surg, Edmonton, AB, Canada.
C3 University of Alberta; Royal Alexandra Hospital
RP Herold, JM (通讯作者)，Hosp Special Surg, Complex Joint Reconstruct Ctr, 535 East 70th St, New York, NY 10021 USA.
OI Herold, Johannes Maximilian/0009-0002-7025-3786; Usukumah-Nocon,
   Allina/0000-0003-4905-5689
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NR 48
TC 2
Z9 2
U1 0
U2 0
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD JUL
PY 2025
VL 40
IS 7
SU 1
BP S271
EP S276
DI 10.1016/j.arth.2025.03.004
EA JUN 2025
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 3ZG4V
UT WOS:001512550800041
PM 40074094
DA 2026-07-24
ER
PT J
AU Pruitt, H
   Watson, AB
   Jennings, JA
   Bumgardner, JD
AF Pruitt, Haley
   Watson, Andrew Blass
   Jennings, J. Amber
   Bumgardner, Joel D.
TI Development of a Benchtop Model for Evaluating the Compatibility of
   Wound Dressing Materials with Negative Pressure Wound Therapy Systems
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MEMBRANE; LAYER
AB Negative pressure wound therapy (NPWT) systems facilitate wound healing by applying sub-atmospheric pressure to the wound bed, which promotes granulation tissue formation and reduces inflammation. Wound dressings can be used with these systems to enhance healing; however, the effects of dressings on NPWT device performance are challenging to assess. The purpose of this study was to develop a benchtop flesh analog model for testing the compatibility of wound dressing materials with NPWT devices. In this study, a chitosan-based advanced wound care device was evaluated for its effects on NPWT performance under maximum and minimum therapy pressures. The goal was to use the model to compare pressure readings and fluid collection for samples with and without the chitosan wound care device. The benchtop model was constructed using a plastic box connected to multiple pressure gauges. A circular defect was created on a piece of pork belly, used as the flesh analog, and inserted into the box. The defect was filled with standard NPWT foam or foam combined with the wound dressing. Simulated body fluid containing bovine serum was added to the box, which was then tested at either maximum (-200 mmHg) or minimum (-25 mmHg) pressures for 72 h. Pressure and fluid collection were recorded every 12 h. The NPWT system successfully maintained pressure over the 72 h test period, both with and without the test dressings. The addition of the wound dressings did not impact fluid collection. The test box proved effective as a benchtop model, as it could be sealed and maintained vacuum conditions over the 72 h testing period. This model successfully demonstrated its utility in evaluating the compatibility of wound dressing materials with NPWT systems.
C1 [Pruitt, Haley; Watson, Andrew Blass; Jennings, J. Amber; Bumgardner, Joel D.] Univ Tennessee, Univ Memphis, Hlth Sci Ctr, Joint Grad Biomed Engn Program, Memphis, TN 38163 USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center; University of Memphis
RP Pruitt, H (通讯作者)，Univ Tennessee, Univ Memphis, Hlth Sci Ctr, Joint Grad Biomed Engn Program, Memphis, TN 38163 USA.
EM hnpruitt@memphis.edu
RI ; Watson, Andrew/OFN-2560-2025; Jennings, Jessica/PGM-2543-2026
OI Bumgardner, Joel/0000-0002-7467-3078; Jennings, Jessica
   Amber/0000-0002-2760-6948; 
FU University of Memphis Department of Biomedical Engineering and Bionova
   Medical
FX This research was made possible with the help of the University of
   Memphis Department of Biomedical Engineering and Bionova Medical.
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NR 15
TC 0
Z9 0
U1 0
U2 2
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD MAY
PY 2025
IS 219
AR E67890
DI 10.3791/67890
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 4DU5Y
UT WOS:001515632000004
PM 40388354
DA 2026-07-24
ER
PT J
AU Bialomyzy, A
   Kotrych, K
   Bogacz, A
   Podralska, M
   Górska, A
   Bialecki, J
   Uzar, I
   Czerny, B
   Kaminski, A
AF Bialomyzy, Agnieszka
   Kotrych, Katarzyna
   Bogacz, Anna
   Podralska, Marta
   Gorska, Aleksandra
   Bialecki, Jacek
   Uzar, Izabela
   Czerny, Boguslaw
   Kaminski, Adam
TI Ozone Therapy and Negative Pressure Wound Therapy in the Treatment of
   Difficult-to-Heal Wounds in Diabetic Foot Syndrome and Charcot
   Neuroarthropathy
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE Charcot neuroarthropathy; diabetic foot syndrome; negative pressure
   wound therapy; ozone therapy
ID VACUUM-ASSISTED CLOSURE; ULCERS; RISK
AB Diabetes, as one of the most common diseases of civilization, is a significant factor of mortality worldwide. Undiagnosed and improperly treated, it leads to the development of a number of complications, including diabetic foot syndrome (DFS) and Charcot neuroarthropathy (CN). Charcot neuroarthropathy is a complex and devastating disease characterized by the presence of neuropathy, progressive deformities, and joint destruction. Risk factors and epidemiological data emphasize the high prevalence of CN in the diabetic population, drawing attention to typical predisposing factors for the development of this disease. Serious complications, such as foot ulcers or amputations, show the scale of the negative impact of CN and DFS on the quality of life of patients. Background/Objectives: The aim of the study was to assess the treatment of foot ulcers in patients with DFS and CN using ozone therapy with simultaneous negative pressure wound therapy (NPWT). Methods: The study included 30 patients aged 39 to 87 years with DFS and 30 patients with CN. Ozone therapy and negative pressure wound therapy were used for the treatment of chronic wounds. Results: The analysis of the results showed a significant reduction in the wound size in both study groups; in patients with DFS, a reduction from 5 cm3 to 0.40 cm3 observed after 3 weeks and to 0.002 cm3 after 6 weeks of therapy, while in patients with CN, a reduction from 8 cm3 to 1.50 cm3 was observed after 3 weeks and to 0.004 cm3 after 6 weeks of therapy. No statistically significant differences were observed in median wound sizes between the DFS and CN groups. Ozone therapy with a value of 70 mu g/mL is an effective method in the treatment of chronic diseases of soft tissue and the skeletal system. In combination with NPWT after cleansing the wound of bone sequestrum, the process increased the density of capillaries by accelerating the synthesis of proteins and collagen and reduced bacterial colonization in the wound. Conclusions: The use of ozone therapy procedures at 70 mu g/mL with negative pressure therapy is effective in the prevention and treatment of infectious bone complications in diabetes, such as diabetic foot syndrome and Charcot neuroarthropathy.
C1 [Bialomyzy, Agnieszka] Eter Med Med Ctr Gdansk, Zabi Kruk 10, PL-80822 Gdansk, Poland.
   [Bialomyzy, Agnieszka] Poznan Univ Med Sci, Dept & Clin Gen Endocrine Surg & Gastrointestinal, Przybyszewskiego 49, PL-60355 Poznan, Poland.
   [Kotrych, Katarzyna] Pomeranian Med Univ, Dept Gen & Dent Radiol, Al Powstancow Wielkopolskch 72, PL-70111 Szczecin, Poland.
   [Bogacz, Anna] Poznan Univ Med Sci, Dept Physiol, Smoluchowskiego 11, PL-60179 Poznan, Poland.
   [Podralska, Marta; Gorska, Aleksandra; Czerny, Boguslaw] Inst Nat Fibres & Med Plants, Dept Stem Cells & Regenerat Med, Kolejowa 2, PL-62064 Plewiska, Poland.
   [Bialecki, Jacek] Francis Raszeja Municipal Hosp, Dept Gen Minimally Invas & Trauma Surg, Mickiewicza 2 St, PL-60834 Poznan, Poland.
   [Uzar, Izabela; Czerny, Boguslaw] Pomeranian Med Univ, Dept Pharmacol & Pharmacoecon, PL-71230 Szczecin, Poland.
   [Kaminski, Adam] Pomeranian Med Univ, Dept Children Orthoped & Musculosceletal Oncol, Unii Lubelskiej 1, PL-71252 Szczecin, Poland.
C3 Poznan University of Medical Sciences; Pomeranian Medical University;
   Poznan University of Medical Sciences; Institute of Natural Fibres &
   Medicinal Plants; Pomeranian Medical University; Pomeranian Medical
   University
RP Bogacz, A (通讯作者)，Poznan Univ Med Sci, Dept Physiol, Smoluchowskiego 11, PL-60179 Poznan, Poland.
EM agnieszka.bialomyzy@gmail.com; kotrych1@gmail.com; aniabogacz23@o2.pl;
   marta.podralska@iwnirz.pl; aleksandra.gorska@iwnirz.pl;
   jacekt.bialecki@gmail.com; uzari@wp.pl; bczerny@wp.pl; emluc@wp.pl
RI ; Czerny, Bogusław/A-9749-2015; Uzar, Izabela/K-5847-2014; Górska,
   Aleksana/OKT-0744-2025
OI Kotrych, Katarzyna/0000-0002-1391-4499; Bogacz,
   Anna/0000-0001-5455-8315; Górska, Aleksana/0000-0001-9833-5738
FU Pomeranian Medical University in Szczecin; Institute of Natural Fibers
   and Medicinal Plants (Poland)
FX The study was supported by statutory projects from Pomeranian Medical
   University in Szczecin and the Institute of Natural Fibers and Medicinal
   Plants (Poland).
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NR 36
TC 2
Z9 2
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN 6
PY 2025
VL 14
IS 12
AR 4017
DI 10.3390/jcm14124017
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4FJ1F
UT WOS:001516691600001
PM 40565762
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fujiwara, H
   Irisawa, R
   Otsuka, M
   Kako, T
   Kaji, T
   Kadono, T
   Koga, M
   Hirosaki, K
   Nokita, Y
   Asano, Y
   Nakanishi, T
   Maekawa, T
   Motegi, SI
   Yoshino, Y
   Hasegawa, M
   Fujimoto, M
   Tachibana, T
AF Fujiwara, Hiroshi
   Irisawa, Ryokichi
   Otsuka, Masaki
   Kako, Tomoko
   Kaji, Tatsuya
   Kadono, Takafumi
   Koga, Monji
   Hirosaki, Kuninori
   Nokita, Yoko
   Asano, Yoshihide
   Nakanishi, Takeshi
   Maekawa, Takeo
   Motegi, Sei-ichiro
   Yoshino, Yuichiro
   Hasegawa, Minoru
   Fujimoto, Manabu
   Tachibana, Takao
CA Wound Pressure Ulcer Burn Guidelines Drafting Comm
   Pressure Ulcer Grp
TI Wound, Pressure Ulcer, and Burn Guidelines (2023)-2: Guidelines for the
   Diagnosis and Treatment of Pressure Ulcers, Third Edition
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE debridement; decubitus; dressings; GRADE; meta-analysis;
   negative-pressure wound therapy; pressure ulcers; systematic review;
   topical medication
ID FIBROBLAST-GROWTH-FACTOR; RANDOMIZED CLINICAL-TRIAL; RISK-ASSESSMENT
   SCALES; DEEP TISSUE-INJURY; SILVER SULFADIAZINE; COST-EFFECTIVENESS;
   FOOT ULCERS; DESIGN-R; STAGE-II; ELECTRICAL-STIMULATION
AB Guidelines for the diagnosis and treatment of pressure ulcers, third edition, is a fully revised guidelines drafted by the Japanese Dermatological Association Wound/Pressure Ulcer/Burn Guidelines Drafting Committee. They were developed in a systematic and transparent manner with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. In the four clinical questions with meta-analyses, debridement, topical medication, dressings, and negative-pressure wound therapy were weakly recommended in the treatment of pressure ulcers. General information on diagnosis, prevention, assessment, and unconventional treatment of pressure ulcers was also provided.
C1 [Fujiwara, Hiroshi] Niigata Univ, Niigata, Japan.
   [Irisawa, Ryokichi] Tokyo Med Univ, Shinjuku Ku, Tokyo, Japan.
   [Otsuka, Masaki] Chutoen Gen Med Ctr, Kakegawa, Japan.
   [Kako, Tomoko] Mie Prefectural Gen Med Ctr, Yokaichi, Japan.
   [Kaji, Tatsuya] Hiroshima City Hiroshima Citizens Hosp, Hiroshima, Japan.
   [Kadono, Takafumi; Nokita, Yoko] St Marianna Univ, Sch Med, Kawasaki, Japan.
   [Koga, Monji] Fukuoka Univ, Fukuoka, Japan.
   [Hirosaki, Kuninori] Hokkaido Med Ctr, Sapporo, Japan.
   [Asano, Yoshihide] Tohoku Univ, Sendai, Japan.
   [Nakanishi, Takeshi] Meiji Univ Integrat Med, Nantan, Japan.
   [Maekawa, Takeo] Jichi Med Univ, Saitama Med Ctr, Saitama, Japan.
   [Motegi, Sei-ichiro] Gunma Univ, Maebashi, Japan.
   [Yoshino, Yuichiro] Japanese Red Cross Kumamoto Hosp, Kumamoto, Japan.
   [Hasegawa, Minoru] Univ Fukui, Fukui, Japan.
   [Fujimoto, Manabu] Osaka Univ, Suita, Japan.
   [Tachibana, Takao] Hoshigaoka Med Ctr, Hirakata, Japan.
C3 Niigata University; Tokyo Medical University; Hiroshima City Hospital;
   St Marianna University; Fukuoka University; Tohoku University; Jichi
   Medical University; Gunma University; University of Fukui; University of
   Osaka
RP Fujiwara, H (通讯作者)，Niigata Univ, Niigata, Japan.
EM hfujiwar@med.niigata-u.ac.jp
RI ; Fujimoto, Manabu/AHA-3461-2022
OI IRISAWA, Ryokichi/0000-0002-9095-3192; Asano,
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NR 285
TC 0
Z9 0
U1 9
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD SEP
PY 2025
VL 52
IS 9
BP e744
EP e794
DI 10.1111/1346-8138.17758
EA JUN 2025
PG 51
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 7ET7A
UT WOS:001517230400001
PM 40569688
OA Bronze
DA 2026-07-24
ER
PT J
AU Sharran, M
   Balaji, G
   Patel, SA
   Badhe, B
AF Sharran, M.
   Balaji, Gopisankar
   Patel, Sukruth Anand
   Badhe, Bhawana
TI Comparison of Scar Quality Between Primary Incisional Negative Pressure
   Wound Therapy and Conventional Surgical Dressing in Patients with Closed
   Forearm Fractures Treated Surgically: A Randomised Controlled Trial
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Forearm; Fractures; Wound; Dressing; Negative pressure
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB BackgroundWound healing and the quality of the scar plays a key role in deciding which dressing technique is better.ObjectiveThe study aimed to determine if primary incisional negative pressure wound therapy provides better scar quality compared to conventional dressing following definitive fixation of closed forearm fractures.MethodsA prospective randomized control trial of patients diagnosed with acute closed forearm fractures who underwent open reduction and internal fixation from April 2022 to January 2024. Patients received either a standard sterile dressing or incisional negative pressure wound therapy (iNPWT). The primary outcome was comparing the histopathological scar quality by examining collagen composition at 12 weeks. Secondary outcomes included assessment of surgical site infection (ASEPSIS Score) and clinical scar assessment using the Patient and Observer Scar Assessment Scale. Univariate logistic regression analyses were performed.Results34 patients were included, 47% received iNPWT (n = 16), and 53% received standard dressings (n = 18). With Masson's trichrome stain,15 participants (93.7%) in the intervention group experienced a favourable outcome with an unadjusted relative risk of 1.13 (95% CI: 0.88-1.43, p = 0.341). With Reticulin stain, 12 participants (75%) in the intervention group exhibited desirable results with an unadjusted relative risk of 0.79 (95% CI: 0.58-1.07,p = 0.13). The intervention group had a mean ASEPSIS score of 1.75 with an SD of 2.11 [95% CI-0.62 to 2.87, p = 0.14]. The calculated difference in mean Patient scar scores between the two groups was 7.31 (p = 0.003), and the observer score was 4.5 (p = 0.043).ConclusionsPatients who underwent iNPWT showed cosmetic satisfaction of scar and favourable outcomes in histopathological assessment with Masson's trichrome stain.Level of Evidence IIIThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
C1 [Sharran, M.; Balaji, Gopisankar; Badhe, Bhawana] Jawaharlal Inst Postgrad Med Educ & Res, Dept Orthopaed, Pondicherry, India.
   [Patel, Sukruth Anand] Maax Super Special Hosp, Shivamogga, Karnataka, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research
RP Balaji, G (通讯作者)，Jawaharlal Inst Postgrad Med Educ & Res, Dept Orthopaed, Pondicherry, India.
EM drgopi9596@gmail.com
RI /AAP-4163-2021
OI M, Sharran/0009-0000-9864-3220
CR Broughton G, 2006, PLAST RECONSTR SURG, V117, p12S, DOI 10.1097/01.prs.0000225430.42531.c2
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NR 18
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD FEB
PY 2026
VL 50
IS 3
BP 1411
EP 1420
DI 10.1007/s00266-025-05014-4
EA JUN 2025
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FD3KX
UT WOS:001518292800001
PM 40576813
DA 2026-07-24
ER
PT J
AU Shishaeva, L
   Li, ZH
   Zuber, F
   Zulian, V
   Roduner, J
   Itel, F
   Ren, Q
AF Shishaeva, Liubov
   Li, Zhihao
   Zuber, Flavia
   Zulian, Vivian
   Roduner, Josua
   Itel, Fabian
   Ren, Qun
TI A simple and specific colorimetric biosensor for early detection of
   Pseudomonas aeruginosa wound infections
SO BIOSENSORS & BIOELECTRONICS
LA English
DT Article
DE Polyvinyl acetate sensor; Wound infections; P. aeruginosa biofilm;
   Negative pressure wound therapy
ID CYANIDE PRODUCTION; POLYVINYL-CHLORIDE; FLUORESCENS; POLYSTYRENE;
   ACETATE; BLENDS; SENSOR
AB Wound healing is a critical aspect of surgical care, often complicated by infections such as those caused by Pseudomonas aeruginosa (PA). In this study, we aim to develop a sensitive and specific colorimetric biosensor which allows early detection and naked-eye monitoring of PA wound infections. We used hydrogen cyanide (HCN) as a PA specific biomarker and aquacyanocobinamide (ACCbi), a vitamin B12 derivative, as the indicator which changes color from orange to violet upon interaction with HCN. We then encapsulated ACCbi with different electrospun fibers, including polyvinyl acetate (PVAc), polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polycaprolactone (PCL), and polyurethane (PU), and evaluated them for suitability as ACCbi carriers. The morphology of the fabricated membranes was analyzed using scanning electron microscopy (SEM). The performance of the materials was assessed for their structural integrity, sensitivity and sensor function. PVAc based membranes demonstrated the best stability and sensitivity, maintaining structural integrity and showing a distinct color change in response to HCN. In a real-world setup of negative pressure wound therapy, the optimized PVAc membranes exhibited a clear color change within 10 h of exposure to PA biofilms formed in vitro and within 12 h to that on ex vivo human skin wounds. The biosensor retained its functionality after two years of storage, offering a promising tool for the early PA detection in clinical wound care.
C1 [Shishaeva, Liubov; Li, Zhihao; Zuber, Flavia; Roduner, Josua; Ren, Qun] Swiss Fed Labs Mat Sci & Technol, Empa, Lab Biointerfaces, CH-9014 St Gallen, Switzerland.
   [Zulian, Vivian] Univ Zurich, Fac Med, CH-8032 Zurich, Switzerland.
   [Itel, Fabian] Swiss Fed Labs Mat Sci & Technol, Lab Biomimet Membranes & Text, Empa, CH-9014 St Gallen, Switzerland.
   [Li, Zhihao] Mayo Clin, William J Liebig Transplant Ctr, Div Transplant Surg, Rochester, MN 55905 USA.
   [Itel, Fabian] Sefar AG, CH-9410 Heiden, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; Swiss Federal
   Laboratories for Materials Science & Technology (EMPA); University of
   Geneva; University of Zurich; Swiss Federal Institutes of Technology
   Domain; Swiss Federal Laboratories for Materials Science & Technology
   (EMPA); Mayo Clinic
RP Li, ZH; Ren, Q (通讯作者)，Swiss Fed Labs Mat Sci & Technol, Empa, Lab Biointerfaces, CH-9014 St Gallen, Switzerland.; Li, ZH (通讯作者)，Mayo Clin, William J Liebig Transplant Ctr, Div Transplant Surg, Rochester, MN 55905 USA.
EM zhihaoli91@gmail.com; Qun.Ren@empa.ch
RI Ren, Qun/A-3532-2016; Itel, Fabian/AAU-2465-2021
OI Ren, Qun/0000-0003-0627-761X; Li, Zhihao/0000-0002-5654-7043; Itel,
   Fabian/0000-0002-4161-2383
FU Swiss National Science Foundation [310031_197617/1]
FX The authors would like to express their gratitude to Rossella Acampora
   and Sixuan Zhang for their assistance with sensor assays, and to
   Professor Jorg Grunert for providing ex-vivo human skin samples. Special
   thanks to Gerhard Eich and Benjamin Preiswerk from Triemli Hospital for
   providing the clinical PA isolates, Jorg Gschwend for his assistance
   with V.A.C. canister adjustments This work was supported by the Swiss
   National Science Foundation (grant No. 310031_197617/1) awarded to Q.R.
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NR 44
TC 4
Z9 4
U1 3
U2 15
PU ELSEVIER ADVANCED TECHNOLOGY
PI OXFORD
PA OXFORD FULFILLMENT CENTRE THE BOULEVARD, LANGFORD LANE, KIDLINGTON,
   OXFORD OX5 1GB, OXON, ENGLAND
SN 0956-5663
EI 1873-4235
J9 BIOSENS BIOELECTRON
JI Biosens. Bioelectron.
PD NOV 1
PY 2025
VL 287
AR 117698
DI 10.1016/j.bios.2025.117698
EA JUN 2025
PG 9
WC Biophysics; Biotechnology & Applied Microbiology; Chemistry, Analytical;
   Electrochemistry; Nanoscience & Nanotechnology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Biotechnology & Applied Microbiology; Chemistry;
   Electrochemistry; Science & Technology - Other Topics
GA 4IV6V
UT WOS:001519055800002
PM 40543172
OA Green Accepted, hybrid
DA 2026-07-24
ER
PT J
AU Imaizumi, K
   Kasajima, H
   Terashima, K
   Furukawa, N
   Ito, K
   Fukasawa, T
   Odagiri, T
   Yamana, D
   Tsuruga, Y
   Umehara, M
   Kurushima, M
   Nakanishi, K
AF Imaizumi, Ken
   Kasajima, Hiroyuki
   Terashima, Kazutoshi
   Furukawa, Naoe
   Ito, Keiichiro
   Fukasawa, Takumu
   Odagiri, Tadashi
   Yamana, Daisuke
   Tsuruga, Yosuke
   Umehara, Minoru
   Kurushima, Michihiro
   Nakanishi, Kazuaki
TI Prophylactic negative-pressure wound therapy using the open method is
   associated with reduced surgical site infection after emergency lower
   gastrointestinal surgery: A retrospective cohort study with propensity
   score analyses
SO MEDICINE
LA English
DT Article
DE gastrointestinal; negative-pressure wound therapy; open method;
   perforation; prophylactic negative-pressure wound therapy; surgical site
   infection
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; COMPLICATIONS; INCISIONS
AB This study investigates the association between prophylactic negative-pressure wound therapy (pNPWT) using the open method and incisional surgical site infection (SSI) following emergency lower gastrointestinal surgery. We retrospectively examined 210 consecutive patients who underwent emergency surgery for lower gastrointestinal tract perforation or necrosis at a single center between January 2018 and March 2023. Outcomes were compared between patients who received pNPWT and those who received conventional wound management. Propensity score analyses included multivariate analysis using the propensity score in the crude cohort, inverse probability of treatment weighting, and 1:2 nearest-neighbor matching. The primary endpoint was the incidence of incisional SSI and the secondary endpoints were wound healing time, postoperative hospital stay, identification of incisional SSI risk factors, and determination of optimal pNPWT management. In the crude cohort (pNPWT = 41, conventional = 169), incisional SSI occurred in 11 (26.8%) and 65 (38.5%) patients, respectively (P = .227). After propensity score analyses, pNPWT was significantly associated with a reduction in incisional SSI, with odds ratios (95% confidence interval) of 0.344 (0.147-0.804; P = .002), 0.260 (0.103-0.794; P = .002), and 0.285 (0.106-0.763; P = .012) in the multivariate analysis, inverse probability of treatment weighting, and propensity score-matched cohort (pNPWT = 30, conventional = 60), respectively. Wound healing time and postoperative hospital stay did not differ significantly between the groups. Risk factors for incisional SSI were poor American Society of Anesthesiologists Physical Status and perforation, with the addition of conventional wound management. Early application of pNPWT (<= 2 days postoperatively) further reduced the incidence of SSI (17.6% vs 71.4%; P = .010). In propensity score analyses, pNPWT was associated with a significant reduction in incisional SSI in contaminated abdominal wounds after lower gastrointestinal surgery. Early application may enhance its effectiveness. pNPWT should be considered for high-risk patients undergoing emergency abdominal surgery.
C1 [Imaizumi, Ken; Kasajima, Hiroyuki; Ito, Keiichiro; Fukasawa, Takumu; Odagiri, Tadashi; Yamana, Daisuke; Tsuruga, Yosuke; Umehara, Minoru; Kurushima, Michihiro; Nakanishi, Kazuaki] Hakodate Municipal Hosp, Dept Gastroenterol Surg, 1-10-1 Minatocho, Hakodate, Hokkaido 0418680, Japan.
   [Terashima, Kazutoshi; Furukawa, Naoe] Hakodate Municipal Hosp, Dept Wound Ostomy & Continence Nurse, Hakodate, Hokkaido, Japan.
RP Imaizumi, K (通讯作者)，Hakodate Municipal Hosp, Dept Gastroenterol Surg, 1-10-1 Minatocho, Hakodate, Hokkaido 0418680, Japan.
EM imaken1983@gmail.com; hiro-kasajima@hospital.hakodate.hokkaido.jp;
   k-terashima@hospital.hakodate.hokkaido.jp;
   n-hurukawa@hospital.hakodate.hokkaido.jp; k.ito199212@gmail.com;
   hockeytf@gmail.com; odgrtds118@outlook.com;
   d-yamana@hospital.hakodate.hokkaido.jp;
   y-tsuruga@hospital.hakodate.hokkaido.jp;
   m-umehara@hospital.hakodate.hokkaido.jp;
   m-kurushima@hospital.hakodate.hokkaido.jp;
   k-nakanishi@hospital.hakodate.hokkaido.jp
RI Imaizumi, Ken/ABW-2302-2022
FU Japanese Society for the Promotion of Science KAKENHI [25K18891]
FX This study was supported by the Japanese Society for the Promotion of
   Science KAKENHI (grant no. 25K18891).
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   Walming S, 2017, BMC SURG, V17, DOI 10.1186/s12893-017-0207-0
   Watanabe M, 2014, SURG INFECT, V15, P256, DOI 10.1089/sur.2012.154
NR 34
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN 27
PY 2025
VL 104
IS 26
AR e43099
DI 10.1097/MD.0000000000043099
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4KA4A
UT WOS:001519858200025
PM 40587691
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Marena, F
   Brambullo, T
   Montrasio, L
   Baldan, N
   Mancini, F
   Vindigni, V
   Bassetto, F
AF Marena, Francesco
   Brambullo, Tito
   Montrasio, Lorenzo
   Baldan, Nicola
   Mancini, Francesca
   Vindigni, Vincenzo
   Bassetto, Franco
TI The role of negative incisional pressure in the prevention of surgical
   site complications in patients with median incisional hernia
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Incisional hernia; Single-use negative pressure; Surgical site
   occurrences; Abdominal wall reconstruction
ID WOUND THERAPY; MESH REPAIR; OUTCOMES; IMPACT
AB BackgroundA single-center retrospective study was conducted to investigate whether the prophylactic application of a single-use negative pressure wound therapy (sNPWT) dressing on closed surgical incisions following incisional hernia (IH) repair of the abdominal wall with meshes reduces the risk of surgical site occurrence (SSO) and the necessity for surgical reoperation. MethodsA retrospective study was conducted on 55 patients with incisional hernias classified as W2 (> 4-10 cm) or W3 (> 10 cm) according to the European Hernia Society classification, treated between 2013 and 2023. All patients underwent open surgical repair with mesh and were assigned to either a conventional flat dressing group (n = 34) or an sNPWT group using PICO 7 (n = 21). Weekly follow-ups were performed, and outcomes were statistically analyzed to compare the incidence of SSOs and reoperations between the two groups. ResultsAt 30 days postoperatively, the control group showed a higher incidence of SSOs (32.35%, 11 cases) compared to the PICO 7 group (19.05%, 4 cases, P = 0.28). The need for surgical reintervention was also higher in the control group (17.65%, 6 cases) versus the PICO 7 group (10.53%, 2 cases, P = 0.41). Regardless of dressing type, elevated BMI (P = 0.02), advanced age, and diabetes were identified as key risk factors for SSOs. ConclusionssNPWT with PICO 7 may reduce SSOs and reoperations in open incisional hernia repair, particularly in high-risk patients with elevated BMI. Although statistical significance was not achieved, sNPWT appears to be a valuable adjunct in postoperative management. Further research is necessary to confirm its efficacy and determine the ideal patient population.
C1 [Marena, Francesco; Brambullo, Tito; Montrasio, Lorenzo; Mancini, Francesca; Vindigni, Vincenzo; Bassetto, Franco] Univ Padua, Dept Neurosci, Clin Plast Surg, Via Giustiniani 2, Padua, Veneto, Italy.
   [Baldan, Nicola] Univ Padua, Dept Surg Oncol & Gastroenterol, Surg Clin 1, Padua, Italy.
C3 University of Padua; University of Padua
RP Brambullo, T (通讯作者)，Univ Padua, Dept Neurosci, Clin Plast Surg, Via Giustiniani 2, Padua, Veneto, Italy.
EM tito.brambullo@unipd.it
RI Brambullo, Tito/AAZ-2332-2020; Vindigni, Vincenzo/K-5059-2016
OI Brambullo, Tito/0000-0002-1041-9660; Vindigni,
   Vincenzo/0000-0001-6638-9010; Marena, Francesco/0009-0003-2455-9589
FU Universita degli Studi di Padova
FX Open access funding provided by Universita degli Studi di Padova.
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD JUN 7
PY 2025
VL 30
IS 1
AR 464
DI 10.1186/s40001-025-02724-y
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 4LK3F
UT WOS:001520799700001
PM 40481597
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Saricaoglu, MC
   Kandemir, M
   Saricaoglu, EM
   Karacuha, AF
   Kadiroglu, E
   Abdullahi, MF
   Inan, MB
   Azap, A
   Akar, AR
AF Saricaoglu, Mehmet Cahit
   Kandemir, Melisa
   Saricaoglu, Elif M.
   Karacuha, Ali Fuat
   Kadiroglu, Ezel
   Abdullahi, Mustafa Farah
   Inan, Mustafa Bahadir
   Azap, Alpay
   Akar, Ahmet Ruchan
TI Driveline Relocation and Vacuum-Assisted Closure for Ventricular Assist
   Device Driveline Infections
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Article
DE left ventricular assist devices; driveline infections; microorganisms;
   driveline dressing
ID OUTCOMES
AB Background: Durable mechanical circulatory support (DMCS) infections remain a serious challenge. Ventricular assist device (VAD)-specific driveline infections (DLIs) are the most common type; however, no consensus exists on their surgical management. We aimed to define the incidence, risk factors, and microbiology of DLIs and discuss the surgical treatment modalities. Methods: We retrospectively reviewed 90 patients who underwent a left or biventricular ventricular assist device (LVAD or BiVAD) implantation with either a HeartMate 2 (Abbott), HeartWare HVAD (Medtronic), or HeartMate 3 (Abbott) in a single center between 1 March 2011 and 30 May 2023. Results: DLIs were detected in 20 (21.5%) patients during the follow-up. The mean duration of VAD support was 561.1 +/- 833.2 days (1-4124 days), while it was 1277.9 +/- 621.6 days in the DLI group. An extended duration of VAD support was associated with higher incidence rates of late-onset DLIs (p < 0.05). A younger age and lower plasma albumin levels were independent predictive factors for the risk of a DLI, with a hazard ratio of 9.77 (95%CI: 1.3-74.5) and 10.55 (95%CI: 1.40-79.35), respectively. The removal of the biofilm with velour and DL relocation through the rectus muscle combined with vacuum-assisted strategies (VAC) were performed in nine patients. One patient developed a recurrent infection, and another patient with a deep DLI subsequently received a heart transplant. No patient underwent a device exchange for an intractable DLI. Conclusions: Our results suggest that DLIs are common infectious complications after VAD implantation, which endanger patient autonomy, and impair their quality of life and overall survival. A DL relocation through the rectus muscles and VAC strategies have a role in controlling DLIs.
C1 [Saricaoglu, Mehmet Cahit; Kandemir, Melisa; Karacuha, Ali Fuat; Kadiroglu, Ezel; Abdullahi, Mustafa Farah; Inan, Mustafa Bahadir; Akar, Ahmet Ruchan] Ankara Univ, Cebeci Hosp, Heart Ctr, Dept Cardiovasc Surg,Sch Med, TR-06340 Ankara, Turkiye.
   [Saricaoglu, Elif M.; Azap, Alpay] Ankara Univ, Ibni Sina Hosp, Sch Med, Dept Infect Dis & Clin Microbiol, TR-06340 Ankara, Turkiye.
C3 Ankara University; Ankara University
RP Akar, AR (通讯作者)，Ankara Univ, Cebeci Hosp, Heart Ctr, Dept Cardiovasc Surg,Sch Med, TR-06340 Ankara, Turkiye.
EM saricaoglu@ankara.edu.tr; melisakandemir1999@gmail.com;
   esaricaoglu@ankara.edu.tr; alifuatkaracuha@gmail.com;
   elifezelkadiroglu@gmail.com; mustaf.59@hotmail.com;
   mbinan@ankara.edu.tr; alpayazap@gmail.com; akar@ankara.edu.tr
RI Sarıcaoğlu, Mehmet Cahit/AEM-6681-2022; KARACUHA,
   Ali'Fuat/LGY-4166-2024; Akar, Ahmet Rüçhan/C-9905-2009; Saricaoglu,
   Elif/JNS-2605-2023; Azap, Alpay/KMA-1874-2024
OI Kandemir, Melisa/0000-0003-2536-3820; Azap, Alpay/0000-0001-5035-055X;
   KARAÇUHA, ALİ FUAT/0009-0000-4280-6289
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NR 36
TC 0
Z9 0
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD JUN 3
PY 2025
VL 12
IS 6
AR 211
DI 10.3390/jcdd12060211
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 4LP8I
UT WOS:001520943200001
PM 40558646
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Feng, MX
   Gadkaree, SK
   Derakhshan, A
AF Feng, Max
   Gadkaree, Shekhar K.
   Derakhshan, Adeeb
TI Vacuum assisted therapy in the head and neck
SO CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
LA English
DT Article
DE chronic wounds; fistula; head and neck; Negative pressure wound therapy;
   vacuum assisted therapy
ID PRESSURE WOUND THERAPY; CLOSURE; MANAGEMENT; RECONSTRUCTION; FISTULA
AB Purpose of reviewTo review the utility of negative pressure wound therapy (NPWT) in the management of head and neck wounds.Recent findingsNPWT has broad applications in the management of head and neck wounds. NPWT has demonstrated success in the treatment of head and neck fistulas and necrotizing soft tissue infections. Immediate application after free flap reconstruction is also shown to be safe, with benefits of reduced tissue edema and promotion of wound healing. NPWT can further be used to prepare chronic wounds for reconstruction, particularly in patients who have undergone radiotherapy. The addition of intermittent saline instillation and dwell time has shown promise in treating head and neck fistulas.SummaryNPWT has been shown to improve wound healing times, reduce length of hospital stays, decrease frequency of dressing changes, and lower pain scores compared to conventional wound care. However, existing evidence is largely limited to case reports and retrospective studies, with few prospective comparative studies. Larger prospective studies are needed to further investigate the efficacy and safety of NPWT in the head and neck.
C1 [Feng, Max; Derakhshan, Adeeb] Loma Linda Univ Hlth, Dept Otolaryngol Head & Neck Surg, Loma Linda, CA USA.
   [Gadkaree, Shekhar K.] Univ Miami, Miller Sch Med, Dept Otolaryngol Head & Neck Surg, Miami, FL USA.
   [Derakhshan, Adeeb] Loma Linda Univ Hlth, Dept Otolaryngol Head & Neck Surg, Div Facial Plast & Reconstruct Surg, Loma Linda, CA USA.
C3 Loma Linda University; University of Miami; Loma Linda University
RP Derakhshan, A (通讯作者)，Loma Linda Univ, Med Ctr, 11234 Anderson St, Loma Linda, CA 92354 USA.
EM adeeb.derakhshan@gmail.com
OI Feng, Max/0000-0002-7042-6213
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NR 47
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1068-9508
EI 1531-6998
J9 CURR OPIN OTOLARYNGO
JI Curr. Opin. Otolaryngol. Head Neck Surg.
PD AUG
PY 2025
VL 33
IS 4
BP 230
EP 235
DI 10.1097/MOO.0000000000001057
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 4NH5L
UT WOS:001522085000003
PM 40402849
DA 2026-07-24
ER
PT J
AU Pang, CJ
   Huo, XY
   Liu, Y
   Yang, ZY
   Liu, L
   Fan, XB
   Xu, SW
AF Pang, Chao-Jian
   Huo, Xiao-Yan
   Liu, Yuan
   Yang, Zong-You
   Liu, Lu
   Fan, Xiao-Bo
   Xu, Shang-Wen
TI Characteristics of hand injuries caused by corn-husker equipment: a new
   type of agricultural injury
SO FRONTIERS IN SURGERY
LA English
DT Article
DE hand; agricultural; infection; corn-husker; type
ID SOFT-TISSUE; FUNGAL-INFECTIONS; MANAGEMENT; EXPERIENCE; EFFICACY;
   THERAPY; CLOSURE; CARE
AB Objectives This study aims to describe the nature and incidence of hand injuries caused by corn-husker machines, as well as the accident conditions and treatment experiences.Methods This retrospective investigation included 34 patients treated at a single institution from August 2018 to August 2021 with postoperative follow-up of more than 12 months. The Hand Injury Severity Scoring System (HISS) was applied to identify the degree of hand injury. Depending on the type of damage, different surgical methods were used, including debridement and suturing, amputation, fracture fixation, negative pressure wound therapy (NPWT), skin flap and skin graft procedures, replantation, and tendon repair. Bacterial culture and antibiotic sensitivity tests were performed when wound secretions were present.Results The average age was 42.1 years, and 76.4% of the patients were male. 17.6% were classified as HISS I, 20.6% each as HISS II and HISS III, and 41.2% as HISS IV. Among the 83 injured fingers (6 thumbs, 13 index, 12 middle, 10 ring, and 7 little fingers), the finger amputation rate was 57.8%. The most common complication was infection, with 13 cases of postoperative infection, resulting in an infection rate of 38.2%. Although NPWT played an important role in treatment, there was no significant difference in infection rates between wounds treated with NPWT and those treated without. Median hospitalization duration was 35 days (IQR: 27-45); median treatment cost was $4740 (IQR: $3255-$6215). Infections significantly impacted both hospitalization duration and treatment costs.Conclusion Corn-husker machine-related hand injuries represent a new type of hand trauma and are often severely mutilating. The selection of appropriate surgical methods and the prevention of infection are crucial aspects in treating such injuries.
C1 [Pang, Chao-Jian; Huo, Xiao-Yan; Liu, Yuan; Fan, Xiao-Bo] First Hosp Handan, Dept Orthopaed Surg, Handan, Hebei, Peoples R China.
   [Yang, Zong-You] Hebei Med Univ, Hosp 3, Dept Orthopaed Surg, Shijiazhuang, Hebei, Peoples R China.
   [Liu, Lu] Hebei Prov Hosp Tradit Chinese Med, Dept Hlth Management, Shijiazhuang, Hebei, Peoples R China.
   [Xu, Shang-Wen] First Hosp Handan, Dept Hand Surg, Handan, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei University of Chinese Medicine
RP Pang, CJ (通讯作者)，First Hosp Handan, Dept Orthopaed Surg, Handan, Hebei, Peoples R China.
EM pangchaojian@163.com
RI ; pang, Chaojian/IAO-4104-2023
OI Yang, Zong-You/0009-0006-6103-3457; 
FU Key Medical Research Projects of Hebei Province [20210568]; Special TCM
   Innovation Project of Hebei Provincial Department of Science and
   Technology [223777130D]; Scientific Research Project of Hebei Province
   Administration of Traditional Chinese Medicine [2024215]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. Supported by the Key
   Medical Research Projects of Hebei Province (Grant No. 20210568);
   Special TCM Innovation Project of Hebei Provincial Department of Science
   and Technology, No. 223777130D; and Scientific Research Project of Hebei
   Province Administration of Traditional Chinese Medicine, No. 2024215.
CR Adani R, 2014, CLIN PLAST SURG, V41, P361, DOI 10.1016/j.cps.2014.03.002
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NR 30
TC 0
Z9 0
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JUN 20
PY 2025
VL 12
AR 1471142
DI 10.3389/fsurg.2025.1471142
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 4NO6M
UT WOS:001522271100001
PM 40620699
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Guo, MB
   Li, M
AF Guo, Mingbo
   Li, Min
TI Clinical Application of Artificial Dermis Combined with Autologous
   Split-thickness Skin Grafting for Traumatic Soft Tissue Defect
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Artificial dermis; Autologous split-thickness skin; Trauma; Negative
   pressure wound therapy
AB To evaluate the clinical efficacy of artificial dermis combined with negative-pressure closed-drainage technique and autologous split-thickness skin grafting in repairing soft tissue defects. A case series Analysis was conducted using the clinical data from 26 patients with traumatic soft tissue defects. Patients underwent co-transplantation of artificial dermis and autologous split-thickness skin grafts. Baseline characteristics, diagnostic and treatment data, and outcomes were recorded. Viable thick skin grafts were observed in all 26 patients. Of these, 24 patients achieved complete healing after a single grafting procedure, whereas two patients required additional debridement and grafting for residual small wounds. After a follow-up period of 9.96 +/- 4.11 months, grafts remained well-integrated in situ, with satisfactory cosmetic outcomes. The combined use of artificial dermis, negative-pressure closed-drainage technique, and autologous split-thickness skin grafting represents an effective and straightforward approach for repairing traumatic soft tissue defects.
C1 [Guo, Mingbo; Li, Min] Sunshine Union Hosp, Dept Joint Surg, Weifang 260000, Shandong, Peoples R China.
RP Li, M (通讯作者)，Sunshine Union Hosp, Dept Joint Surg, Weifang 260000, Shandong, Peoples R China.
EM zilong5305@sina.com
FU Weifang Municipal Health Commission [WFWSJK-2024-221]
FX The research leading to these results received funding from [Project
   approved by the Weifang Municipal Health Commission] under Grant
   Agreement No[WFWSJK-2024-221].
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NR 25
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD APR
PY 2026
VL 88
IS 2
BP 328
EP 334
DI 10.1007/s12262-025-04384-y
EA JUL 2025
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GQ9SL
UT WOS:001522674500001
DA 2026-07-24
ER
PT J
AU Parise, AC
   Mateo, G
   Sierra, MD
   Benso, JD
   Funtes, NA
   Villena, DS
   Cafruni, VM
   Carrasco, NM
   Araujo, MGS
AF Parise, Ana C.
   Mateo, Gonzalo
   Sierra, Mariana de Paz
   Benso, Jose D.
   Funtes, Nora A.
   Villena, Daniel S.
   Cafruni, Virginia M.
   Carrasco, Nelly M.
   Araujo, Maria G. Santini
TI Osteomyelitis in diabetic foot: reconstruction with autologous bone
   graft
SO MEDICINA-BUENOS AIRES
LA Spanish
DT Article
DE diabetic foot; polymethylmethacrylate cement spacer; limb salvage;
   osteomyelitis; metatarsophalangeal arthrodesis
ID METATARSOPHALANGEAL JOINT; ARTHRODESIS; OUTCOMES; SALVAGE; SPACER
AB Moderate to severe infections in the diabetic foot (DF), such as osteomyelitis, frequently require surgical intervention and prolonged antibiotic therapy. Amputation is often unavoidable, with high morbidity and mortality rates in the initial years. Bone resection can lead to deformities and loss of foot function, introducing further complications. This report presents a case of a 45-year-old patient with type 2 Diabetes Mellitus (DM) and osteomyelitis in the first ray, managed through surgical debridement, an antibiotic-loaded cement spacer, and vacuum-assisted closure (VAC) to control infection, along with a six-week antibiotic treatment. Following favorable clinical progress and normalization of inflammatory markers, a second-stage surgical reconstruction was performed using autologous bone grafting and metatarsophalangeal arthrodesis with internal fixation to preserve the length and functionality of the first ray. The patient demonstrated positive outcomes over the next 40 months, with no recurrence of infection.
C1 [Parise, Ana C.; Sierra, Mariana de Paz; Benso, Jose D.; Villena, Daniel S.; Cafruni, Virginia M.; Carrasco, Nelly M.; Araujo, Maria G. Santini] Hosp Italiano Buenos Aires, Tte Gral Juan D Peron 4190, RA-1199 Mar Del Plata, Buenos Aires, Argentina.
   [Mateo, Gonzalo; Funtes, Nora A.] Hosp Privado Comun, Mar del Plata, Buenos Aires, Argentina.
C3 Hospital Italiano de Buenos Aires
RP Parise, AC (通讯作者)，Hosp Italiano Buenos Aires, Tte Gral Juan D Peron 4190, RA-1199 Mar Del Plata, Buenos Aires, Argentina.
EM ana.parise@hospitalitaliano.org.ar
RI Araújo, Maria/ACG-5919-2022
CR Berardinelli EM, 2021, ACTA BIOQUIM CLIN L, V55, P61
   Carro GV, 2023, MEDICINA-BUENOS AIRE, V83, P428
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   Mateo G, 2022, AAOT-TL
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NR 14
TC 0
Z9 0
U1 0
U2 0
PU MEDICINA (BUENOS AIRES)
PI BUENOS AIRES
PA DONATO ALVAREZ 3150, 1427 BUENOS AIRES, ARGENTINA
SN 0025-7680
EI 1669-9106
J9 MEDICINA-BUENOS AIRE
JI Med.-Buenos Aires
PD MAY-JUN
PY 2025
VL 85
IS 3
BP 601
EP 605
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4RH1A
UT WOS:001524789300013
PM 40577147
DA 2026-07-24
ER
PT J
AU Berjaoui, N
   Santos, F
   Curti, F
   Chan, PS
   Lampridis, S
   Patel, A
   Bille, A
AF Berjaoui, Nabih
   Santos, Felix
   Curti, Fabiana
   Chan, Puiyee Sophia
   Lampridis, Savvas
   Patel, Akshay
   Bille, Andrea
TI Surgical management of complex mediastinitis: an 8-year single-centre
   experience reinforcing the role of open thoracotomy
SO INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE mediastinitis; surgery; thoracotomy; video-assisted thoracoscopic
   surgery; VATS
ID DESCENDING NECROTIZING MEDIASTINITIS; ESOPHAGECTOMY
AB OBJECTIVES Mediastinitis is an infection affecting the mediastinum, often caused by cardiovascular or thoracic surgery procedures. Management entails antibiotic therapy, surgical debridement, drainage of infected sites and immediate or delayed closure. Negative pressure wound therapy is useful in cases of delayed sternal closure. Several approaches for mediastinal drainage have been proposed, but there is no consensus on the thoracic intervention approach.METHODS A single-centre, retrospective analysis from the UK analysed data from 19 patients who underwent surgical management for mediastinitis between September 2015 and April 2023. Our primary aim was to describe the outcomes from our series where we predominantly employed an open surgical approach.RESULTS The mean age of our cohort was 49 +/- 17.12 years old; the mean performance status (PS ECOG) was 2 +/- 0.77. Two people were known smokers (10.53%), while five were non-smokers (26.31%). Fifteen patients underwent an open operation (78.85%), with rest undergoing a minimally invasive approach. The majority of procedures were undertaken from the right-hand side. The overall intensive care unit admission rate was 68.42% (n = 13) with an in-hospital complication rate of 5.26% (n = 1). This was a respiratory arrest secondary to mucous plugging. There were no in-hospital deaths, and median follow-up was 41 months (22-50). Overall survival at 3 years was 85%.CONCLUSIONS Open thoracotomy remains an important surgical strategy in the management of complex mediastinitis, but further validation is required through larger, prospective studies.
   Mediastinitis is a rare but life-threatening condition that may result from deep sternal wound infection (DSWI), oesophageal perforation or descending necrotizing mediastinitis (DNM) [1].
C1 [Berjaoui, Nabih; Curti, Fabiana; Chan, Puiyee Sophia; Patel, Akshay; Bille, Andrea] Guys & St ThomasNHS Fdn Trust, Dept Thorac Surg, London, England.
   [Santos, Felix] Kings Coll Med Sch, London, England.
   [Lampridis, Savvas] 424 Gen Mil Hosp, Dept Thorac Surg, Thessaloniki, Greece.
   [Patel, Akshay] Univ Birmingham, Inst Immunol & Immunotherapy, Birmingham, England.
C3 University of London; King's College London; University of Birmingham
RP Patel, A (通讯作者)，Guys & St ThomasNHS Fdn Trust, Dept Thorac Surg, London, England.; Patel, A (通讯作者)，Univ Birmingham, Inst Immunol & Immunotherapy, Birmingham, England.
EM ajp.788@gmail.com
RI ; Lampridis, Savvas/H-3539-2019
OI Santos, Felix/0009-0006-1795-1525; Patel, Akshay/0000-0001-9170-8618;
   Lampridis, Savvas/0000-0003-2827-5826
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   Price TN, 2013, ANN THORAC SURG, V95, P1154, DOI 10.1016/j.athoracsur.2012.11.045
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NR 26
TC 1
Z9 1
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2753-670X
J9 INTERDISC CARDIOV TH
JI Interdiscip. Cardiovasc. Thorac. Surg.
PD JUL
PY 2025
VL 40
IS 7
AR ivaf154
DI 10.1093/icvts/ivaf154
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 4UC4Y
UT WOS:001526707400001
PM 40576454
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Stanciu, CT
   Velimirovici, MD
   Vermesan, D
   Pilut, CN
   Stana, L
   Bratosin, F
   Pop, DL
   Hogea, B
AF Stanciu, Cristina-Teodora
   Velimirovici, Milan Daniel
   Vermesan, Dinu
   Pilut, Ciprian Nicolae
   Stana, Loredana
   Bratosin, Felix
   Pop, Daniel Laurentiu
   Hogea, Bogdan
TI Comparative Recovery After Acute Lower-Limb Wounds Treated with
   Negative-Pressure Wound Therapy and Three Gradations of Manual
   Rehabilitation
SO HEALTHCARE
LA English
DT Article
DE negative-pressure wound therapy; physical therapy modalities;
   proprioceptive neuromuscular facilitation; lower extremity injuries;
   wound healing
ID SF-36
AB Background and Objectives: Negative-pressure wound therapy (NPWT) expedites tissue repair, yet functional recovery depends on adjunct rehabilitation. Evidence from high-resource settings is difficult to translate to Romanian county hospitals, where advanced devices are scarce. The objective of this study is to determine whether two tiers of low-technology, therapist-delivered exercise improve mobility, oedema resolution, pain and quality-of-life (QoL) beyond NPWT alone in adults with acute lower-limb wounds. Methods: A single-centre, prospective observational study (January 2021-June 2024) enrolled 92 patients and randomised them unevenly into: Group A, NPWT only (n = 39); Group B, NPWT + routine physiotherapy (n = 33); Group C, NPWT + enhanced manual programme (n = 20). All received -125 mmHg continuous suction; rehabilitation started 48 h post-operation. Primary outcomes were ankle dorsiflexion and knee flexion at 12 weeks. Secondary outcomes included calf circumference, ultrasound oedema depth, Manual Muscle Testing (MMT), pain (VAS), analgesic use and SF-36 domains through 24 weeks. Results: Baseline characteristics were similar (p > 0.40). At 12 weeks dorsiflexion reached 20.1 +/- 1.8 degrees in Group C, surpassing Group B (18.4 +/- 2.1 degrees; p = 0.004) and Group A (16.0 +/- 2.3 degrees; p < 0.001). Knee flexion followed the same gradient (140.8 +/- 3.2 degrees, 137.6 +/- 3.4 degrees, 133.4 +/- 3.8 degrees respectively). Oedema depth fell fastest in Group C (0.4 +/- 0.2 mm by day 42) versus B (0.6 +/- 0.2 mm) and A (0.8 +/- 0.3 mm). Week-12 MMT grade >= 4.5 was attained by 95% of Group C, 85% of B and 72% of A (chi(2) = 10.9, p = 0.004). VAS pain fell more steeply with each rehabilitation layer, paralleled by a stepwise decline in daily tramadol. All SF-36 domains were highest in Group C at 24 weeks (Physical Function 88.7 +/- 4.8 vs. 85.1 +/- 5.4 vs. 78.2 +/- 5.9; p < 0.001). Mobility correlated positively with QoL (r = 0.66) and inversely with pain and oedema. Conclusions: In a resource-constrained Romanian setting, adding structured manual physiotherapy to NPWT produced meaningful functional and patient-centred gains, while an "enhanced" programme incorporating daily PNF and elastic-band strengthening delivered the largest observed benefit. These findings justify prioritising therapist-led interventions even where sophisticated equipment is unavailable.
C1 [Stanciu, Cristina-Teodora] Victor Babes Univ Med & Pharm, Doctoral Sch, Timisoara 300041, Romania.
   [Velimirovici, Milan Daniel] Victor Babes Univ Med & Pharm, Fac Nursing, Dept Nursing 1, Timisoara 300041, Romania.
   [Vermesan, Dinu; Pop, Daniel Laurentiu; Hogea, Bogdan] Victor Babes Univ Med & Pharm, Dept Orthoped 16, Discipline Orthoped & Traumatol 1, Timisoara 300041, Romania.
   [Pilut, Ciprian Nicolae] Victor Babes Univ Med & Pharm, Dept Dermatol, Timisoara 300041, Romania.
   [Stana, Loredana] Victor Babes Univ Med & Pharm, Dept Discipline Anat & Embryol 1, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Bratosin, Felix] Victor Babes Univ Med & Pharm, Dept Infect Dis, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Victor Babes University of Medicine & Pharmacy,
   Timisoara; Victor Babes University of Medicine & Pharmacy, Timisoara
RP Pilut, CN (通讯作者)，Victor Babes Univ Med & Pharm, Dept Dermatol, Timisoara 300041, Romania.; Stana, L (通讯作者)，Victor Babes Univ Med & Pharm, Dept Discipline Anat & Embryol 1, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
EM cristina.stanciu@umft.ro; milan.velimirovici@umft.ro; dinu@vermesan.ro;
   pilut.nicolae@umft.ro; loredana.stana@umft.ro; felix.bratosin@umft.ro;
   daniellaurentiupop@yahoo.com; hogea.bogdan@umft.ro
RI Nicolae Ciprian, Pilut/LWI-2658-2024; Bratosin, Felix/HDN-8724-2022
OI Nicolae Ciprian, Pilut/0009-0006-9681-8289; Bratosin,
   Felix/0000-0003-4711-4315; Hogea, Bogdan/0000-0003-4924-7832
FU Victor Babes University of Medicine and Pharmacy; Victor Babes
   University of Medicine and Pharmacy for paying the APC
FX We acknowledge the Victor Babes University of Medicine and Pharmacy for
   paying the APC.
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NR 35
TC 0
Z9 0
U1 1
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD JUN 23
PY 2025
VL 13
IS 13
AR 1496
DI 10.3390/healthcare13131496
PG 12
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 4UU6W
UT WOS:001527181500001
PM 40648523
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Heilani, MW
   Teubner, D
   Haist, T
   Knabe, M
   Malkomes, P
   Michael, FA
   Stumpf, M
   Zeuzem, S
   Bechstein, WO
   Friedrich-Rust, M
   Dultz, G
AF Heilani, Myriam W.
   Teubner, Daniel
   Haist, Thomas
   Knabe, Mate
   Malkomes, Patrizia
   Michael, Florian Alexander
   Stumpf, Michael
   Zeuzem, Stefan
   Bechstein, Wolf Otto
   Friedrich-Rust, Mireen
   Dultz, Georg
TI Closing the gap: endoscopic treatment of esophageal anastomotic
   leakage-a retrospective cohort study
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Anastomotic leakage; Esophageal defects; Endoscopic vacuum therapy;
   Endoscopic vacuum-assisted closure; Esosponge; SEMS
ID VACUUM-ASSISTED CLOSURE; DEFECT CLOSURE; THERAPY; STENT; COMPLICATIONS;
   SMOKING
AB Background A variety of endoscopic techniques are available for the closure of esophageal defects, each offering distinct advantages. Endoscopic vacuum therapy (EVT) has emerged as a highly effective approach. Alternatively, fully covered self-expanding metal stents (SEMS) can be placed intraluminally until defect closure is achieved. For smaller defects, over-the-scope clips (OTSC (R)) provide a viable option. However, comparative data remain limited and reported closure rates vary widely across the literature. This study aimed to evaluate and compare closure rates of postoperative anastomotic leaks treated with EVT, SEMS, and OTSC (R) at two specialized centers in Germany. Methods This retrospective study included all patients treated endoscopically for anastomotic leakage at two tertiary gastroenterological centers between May 2007 and February 2023. The primary endpoint was successful endoscopic defect closure. Secondary endpoints included in-hospital mortality, need for revision surgery, duration of therapy, hospital stay length, time to treatment initiation, and procedure-related complications.<br /> Results A total of 59 patients (71% male, mean age 64 years) were included. In 94.9% of cases, surgery was performed for oncologic indications; 46% had received neoadjuvant therapy. The most common procedure was Ivor Lewis esophagectomy (89.8%). EVT was used in 24 patients, SEMS in 32, and OTSC (R) in 14. The overall closure rate was 78.0%. Patients with successful closure had a significantly lower ASA score (p = 0.039), smaller defects (<= 1 cm: 57.8% vs. 15.4%, p = 0.007), lower in-hospital mortality (2.2% vs. 38.5%, p < 0.001), and reduced need for revision surgery (0% vs. 61.5%, p < 0.001).<br /> Conclusions The success of endoscopic therapy is closely linked to patient health status and defect size. Notably, esophageal defects <= 1 cm can almost always be closed successfully using endoscopic methods.
C1 [Heilani, Myriam W.; Michael, Florian Alexander; Zeuzem, Stefan; Friedrich-Rust, Mireen; Dultz, Georg] Goethe Univ Frankfurt, Univ Hosp, Med Clin 1, Frankfurt, Germany.
   [Teubner, Daniel; Stumpf, Michael] Helios Dr Horst Schmidt Kliniken, Wiesbaden, Germany.
   [Haist, Thomas] Asklepios Paulinenklin Wiesbaden, Wiesbaden, Germany.
   [Knabe, Mate] Bethanien Hosp, Ctr Gastroenterol Bethanien, Frankfurt, Germany.
   [Malkomes, Patrizia] Ruhr Univ Bochum, Knappschaft Kliniken Univ Hosp Bochum, Dept Surg, Bochum, Germany.
   [Bechstein, Wolf Otto] Goethe Univ Frankfurt, Univ Hosp, Dept Gen Visceral Transplant & Thorac Surg, Frankfurt, Germany.
C3 Goethe University Frankfurt; Goethe University Frankfurt Hospital; Ruhr
   University Bochum; Goethe University Frankfurt; Goethe University
   Frankfurt Hospital
RP Heilani, MW (通讯作者)，Goethe Univ Frankfurt, Univ Hosp, Med Clin 1, Frankfurt, Germany.
EM heilani@med.uni-frankfurt.de
RI /AAE-2986-2019; Michael, Florian/HCH-8091-2022
OI Heilani, Myriam/0000-0002-0948-2777
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
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NR 36
TC 3
Z9 3
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD SEP
PY 2025
VL 39
IS 9
BP 5643
EP 5653
DI 10.1007/s00464-025-11904-0
EA JUL 2025
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6XH3Y
UT WOS:001528757500001
PM 40659949
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Abul, A
   Abel, A
   Al-Saffar, M
   Iskeirjeh, S
   Badran, S
AF Abul, Ahmad
   Abel, Ali
   Al-Saffar, Mohammad
   Iskeirjeh, Sara
   Badran, Saif
TI Efficacy of closed-incision negative pressure wound therapy in
   abdominal-based autologous breast reconstruction: A systematic review
   and meta-analysis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Closed-incision Negative Pressure Wound Therapy; CiNPWT; DIEP flap;
   Donor site morbidity; Postoperative complications; Breast reconstruction
ID DONOR-SITE COMPLICATIONS; MANAGEMENT; IMPACT
AB Introduction: Abdominal-based free tissue transfers, such as the Deep Inferior Epigastric Perforator (DIEP) flap, are widely utilized in autologous breast reconstruction. These procedures are often complicated by wound healing issues at the donor site, including wound dehiscence, seroma formation, and surgical site infections (SSIs). Closed Incision Negative Pressure Wound Therapy (ciNPWT) has been suggested to improve healing outcomes and reduce the incidence of postoperative complications. This synthesis evaluated the efficacy of ciNPWT compared to standard dressings in abdominal-based autologous breast reconstruction. Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. Randomized controlled trials and observational studies assessing ciNPWT versus standard dressings in patients undergoing abdominal-based free flap breast reconstruction were included. Primary and secondary outcomes analyzed were wound dehiscence, SSIs, seroma formation, and length of stay. Data from multiple databases were independently reviewed and synthesized using Review Manager 5.4 and Microsoft Excel. Studies were rigorously selected and assessed for risk of bias. Results: Of the 348 identified articles, 13 studies met the inclusion criteria, comprising three randomized controlled trials and 10 observational studies, totaling 2882 patients. The ciNPWT group showed a 42% reduction in wound dehiscence (OR 0.58, 95% CI 0.42-0.79; p = 0.0007), with moderate heterogeneity (I2 = 36%). No significant differences were found for surgical site infections (OR 0.77, 95% CI 0.50-1.18; p = 0.23) and seroma formation (OR 0.66, 95% CI 0.38-1.12; p = 0.15). Variations in length of stay data prevented quantitative analysis. Conclusion: ciNPWT demonstrates a significant reduction in wound dehiscence, highlighting its value in enhancing postoperative care, especially for high-risk patients. However, further research involving larger, multicenter randomized controlled trials is necessary to fully elucidate ciNPWT's role in reducing other complications and its broader clinical applicability. (c) 2025 The Author(s). Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Abul, Ahmad; Al-Saffar, Mohammad] Jaber Al Ahmad Hosp, Dept Plast & Reconstruct Surg, Minist Hlth, Kuwait, Kuwait.
   [Abel, Ali] Ibn Sina Hosp, Al Babtain Ctr Burns & Plast Surg, Minist Hlth, Kuwait, Kuwait.
   [Iskeirjeh, Sara] Hamad Gen Hosp, Hamad Med Corp, Dept Plast & Reconstruct Surg, Doha, Qatar.
   [Badran, Saif] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, Australia.
   [Badran, Saif] Washington Univ, Sch Med, Div Plast & Reconstruct Surg, St Louis, MO USA.
C3 Hamad Medical Corporation; Hamad General Hospital; Flinders University;
   Washington University (WUSTL)
RP Badran, S (通讯作者)，Washington Univ, Dept Surg, Div Plast Surg, Div Surg Sci,Sch Med, 660 S Euclid Ave, St. Louis, MO 63110 USA.
EM badran@wustl.edu
OI Abul, Ahmad/0000-0003-3242-2630; Iskeirjeh, Sara/0009-0009-1128-3847;
   Badran, Saif/0000-0002-5955-1734
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   Ottawa Hospital Research Institute, about us
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NR 28
TC 3
Z9 3
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2025
VL 107
BP 151
EP 161
DI 10.1016/j.bjps.2025.06.032
EA AUG 2025
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 4XL4K
UT WOS:001528980400001
PM 40617064
OA hybrid
DA 2026-07-24
ER
PT J
AU Wang, TK
   Chen, CH
   Chiu, WK
   Ni, CH
   Wang, CY
   Chen, KH
   Chen, CH
AF Wang, Ting-Kuang
   Chen, Chien-Hsin
   Chiu, Wen-Kuan
   Ni, Cheng-Hua
   Wang, Chin-Yun
   Chen, Kee-Hsin
   Chen, Chiehfeng
TI Negative pressure wound therapy for colorectal incisions: a systematic
   review and meta-analysis of controlled trials
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE colorectal surgery; meta-analysis; negative pressure wound therapy;
   surgical incision; surgical site infection; systematic review; wound;
   wound care; wound dressing; wound healing
ID SURGICAL SITE INFECTION; PREVENTION; LAPAROTOMY; CLOSURE
AB Objective: Negative pressure wound therapy (NPWT) has demonstrated promising results in reducing surgical site infection (SSI) rates following orthopaedic, vascular, cardiothoracic, plastic and abdominal surgery. The literature on use of NPWT on colorectal incisions is growing, with several randomised controlled trials (RCTs); however, findings have been inconsistent. This review evaluated the effectiveness and safety of NPWT for colorectal incisions in elective and emergency surgery. Method: The Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Cumulative Index to Nursing and Allied Health Literature, and ClinicalTrials.gov databases were searched for RCTs and non-RCTs comparing NPWT with standard of care. Results: A total of five RCTs and six non-RCTs were included (with a total number of patients 2193). NPWT significantly reduced the rate of infection in colorectal incisions (odds ratio (OR): 0.57; 95% confidence interval (CI): 0.41, 0.78; I-2=14%; p<0.0005) and wound complications of the colorectal surgical incisions (OR: 0.33; 95% CI: 0.13, 0.88; I-2=59%; p=0.03). NPWT also shortened the wound healing time by three days (mean difference: -2.98; 95% CI: -4.99, -0.97; I-2=0%; p=0.004). Subgroup analysis revealed that NPWT conferred greater benefits on wounds resulting from life-threatening emergency surgery, and contaminated or dirty-infected wounds. Conclusion: The findings of this review showed that NPWT is an effective intervention for the closure of wounds in patients following colorectal surgery, and lead to a significant reduction in SSIs, overall wound complications, and mean complete wound healing time. It was particularly effective in emergency cases and in contaminated to dirty-infected wounds. Treatment options should be considered in terms of cost-benefits and adequate patient selection during shared decision-making.
C1 [Wang, Ting-Kuang; Ni, Cheng-Hua; Wang, Chin-Yun; Chen, Kee-Hsin] Taipei Med Univ, Wan Fang Hosp, Ctr Nursing & Healthcare Res Clin Practice Applica, Taipei, Taiwan.
   [Wang, Ting-Kuang; Ni, Cheng-Hua; Wang, Chin-Yun; Chen, Kee-Hsin] Taipei Med Univ, Wan Fang Hosp, Dept Nursing, Taipei, Taiwan.
   [Wang, Ting-Kuang; Chen, Chien-Hsin] Taipei Med Univ, Wan Fang Hosp, Dept Surg, Div Colorectal Surg, Taipei, Taiwan.
   [Wang, Ting-Kuang] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan.
   [Chen, Chien-Hsin; Chiu, Wen-Kuan] Taipei Med Univ, Coll Med, Sch Med, Dept Surg, Taipei, Taiwan.
   [Chiu, Wen-Kuan; Chen, Chiehfeng] Taipei Med Univ, Wan Fang Hosp, Dept Surg, Div Plast Surg, Taipei, Taiwan.
   [Ni, Cheng-Hua] Taipei Med Univ, Coll Nursing, Sch Nursing, Taipei, Taiwan.
   [Chen, Kee-Hsin] Taipei Med Univ, Coll Nursing, Postbaccalaureate Program Nursing, Taipei, Taiwan.
   [Chen, Kee-Hsin; Chen, Chiehfeng] Taipei Med Univ, Cochrane Taiwan, Taipei, Taiwan.
   [Chen, Kee-Hsin] Taipei Med Univ, Wan Fang Hosp, Evidence Based Knowledge Translat Ctr, Taipei, Taiwan.
   [Chen, Chiehfeng] Taipei Med Univ, Wan Fang Hosp, Evidence Based Med Ctr, Taipei, Taiwan.
   [Chen, Chiehfeng] Taipei Med Univ, Coll Med, Sch Med, Dept Publ Hlth, Taipei, Taiwan.
C3 Taipei Municipal WanFang Hospital; Taipei Medical University; Taipei
   Municipal WanFang Hospital; Taipei Medical University; Taipei Medical
   University; Taipei Municipal WanFang Hospital; Taipei Medical
   University; Taipei Medical University; Taipei Medical University; Taipei
   Municipal WanFang Hospital; Taipei Medical University; Taipei Medical
   University; Taipei Medical University; Taipei Medical University; Taipei
   Municipal WanFang Hospital; Taipei Municipal WanFang Hospital; Taipei
   Medical University; Taipei Medical University
RP Chen, KH (通讯作者)，Taipei Med Univ, Wan Fang Hosp, Ctr Nursing & Healthcare Res Clin Practice Applica, Taipei, Taiwan.; Chen, KH (通讯作者)，Taipei Med Univ, Wan Fang Hosp, Dept Nursing, Taipei, Taiwan.; Chen, CH (通讯作者)，Taipei Med Univ, Wan Fang Hosp, Dept Surg, Div Plast Surg, Taipei, Taiwan.; Chen, KH (通讯作者)，Taipei Med Univ, Coll Nursing, Postbaccalaureate Program Nursing, Taipei, Taiwan.; Chen, KH; Chen, CH (通讯作者)，Taipei Med Univ, Cochrane Taiwan, Taipei, Taiwan.; Chen, KH (通讯作者)，Taipei Med Univ, Wan Fang Hosp, Evidence Based Knowledge Translat Ctr, Taipei, Taiwan.; Chen, CH (通讯作者)，Taipei Med Univ, Wan Fang Hosp, Evidence Based Med Ctr, Taipei, Taiwan.; Chen, CH (通讯作者)，Taipei Med Univ, Coll Med, Sch Med, Dept Publ Hlth, Taipei, Taiwan.
EM keehsin@tmu.edu.tw; clifchen@tmu.edu.tw
RI Chen, Chien/QOA-7803-2026; Chen, Kee-Hsin/W-3576-2019
OI Chen, Kee-Hsin/0000-0001-9772-482X
CR Abadía P, 2021, SURG INFECT, V22, P234, DOI 10.1089/sur.2019.309
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   Zwanenburg PR, 2020, ANN SURG, V272, P81, DOI 10.1097/SLA.0000000000003644
NR 55
TC 1
Z9 1
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2025
VL 34
IS 7
BP 526
EP 537
DI 10.12968/jowc.2022.0219
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 4ZK9P
UT WOS:001530327700001
PM 40632066
DA 2026-07-24
ER
PT J
AU Ohno, R
   Yoshimatsu, G
   Itatani, Y
   Okamura, R
   Yoshida, Y
   Maekawa, H
   Hoshino, N
   Hida, K
   Obama, K
   Hasegawa, S
AF Ohno, Ryo
   Yoshimatsu, Gumpei
   Itatani, Yoshiro
   Okamura, Ryosuke
   Yoshida, Yu
   Maekawa, Hisatsugu
   Hoshino, Nobuaki
   Hida, Koya
   Obama, Kazutaka
   Hasegawa, Suguru
TI Prophylactic negative pressure wound therapy with Prevena™ to prevent
   perineal surgical site infection
SO SURGERY TODAY
LA English
DT Article
DE Surgical site infection; Prophylactic negative-pressure wound therapy;
   Perineal wounds; Abdominoperineal resection; Total pelvic exenteration
ID VACUUM-ASSISTED CLOSURE; ABDOMINOPERINEAL RESECTION; RECTAL-CANCER;
   RECONSTRUCTION; COMPLICATIONS; MANAGEMENT; EXCISION; UTILITY
AB PurposeSurgical site infection (SSI) of perineal wounds after abdominoperineal resection (APR) or total pelvic exenteration (TPE) for pelvic malignancies is a common postoperative complication. Although several attempts have been made to prevent this complication, SSI of perineal wounds remain common. The efficacy of prophylactic negative-pressure wound therapy (NPWT) in abdominal surgery has been reported; however, few studies have focused on perineal wounds, where the incidence of SSI is particularly high. This study investigated the prophylactic effect of NPWT on closed perineal wounds after APR/TPE to prevent SSI.MethodsThis study enrolled 127 consecutive patients with malignant tumors who underwent elective APR/TPE between January 2013 and December 2022. We used the Prevena (TM) incision management system (IMS) on the perineal wound in 10 patients for prophylactic NPWT (pNPWT group), whereas 117 patients underwent conventional primary closure (cPC group). We compared the incidence of perineal wound SSI between the groups and explored the risk factors associated with SSI.ResultsPatients' backgrounds were essentially the same between the groups. There were no SSI cases in the pNPWT group, whereas 29 patients (25%) in the cPC group had SSI (P = 0.067). Exploratory analyses revealed that a body mass index >= 25, disinfection method, and neoadjuvant chemotherapy were significantly correlated with SSI in perineal wounds.ConclusionProphylactic NPWT for closed perineal wounds after APR/TPE in patients with malignancies can be effective in preventing SSI.
C1 [Ohno, Ryo; Itatani, Yoshiro; Okamura, Ryosuke; Yoshida, Yu; Maekawa, Hisatsugu; Hoshino, Nobuaki; Hida, Koya; Obama, Kazutaka] Kyoto Univ, Grad Sch Med, Dept Surg, 54 Shogoin Kawahara Cho,Sakyo Ku, Kyoto 6068507, Japan.
   [Ohno, Ryo; Yoshimatsu, Gumpei; Hasegawa, Suguru] Fukuoka Univ, Fac Med, Dept Gastroenterol Surg, 7-45-1 Nanakuma,Jonan Ku, Fukuoka 8140180, Japan.
C3 Kyoto University; Fukuoka University
RP Itatani, Y (通讯作者)，Kyoto Univ, Grad Sch Med, Dept Surg, 54 Shogoin Kawahara Cho,Sakyo Ku, Kyoto 6068507, Japan.
EM itatani@kuhp.kyoto-u.ac.jp
RI ; Yoshimatsu, Gumpei/LYO-8890-2024; OBAMA, KAZUTAKA/AAW-8263-2021; Hida,
   Koya/AFU-1462-2022; Maekawa, Hisatsugu/MSW-9355-2025; Itatani,
   Yoshiro/GXA-0613-2022
OI Itatani, Yoshiro/0000-0001-7356-7065; 
CR Althumairi AA, 2016, WORLD J SURG, V40, P1755, DOI 10.1007/s00268-016-3450-0
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NR 25
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD DEC
PY 2025
VL 55
IS 12
BP 1945
EP 1952
DI 10.1007/s00595-025-03102-1
EA JUL 2025
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9OS9U
UT WOS:001530556900001
PM 40676202
DA 2026-07-24
ER
PT J
AU Liu, GH
   Xu, ZY
   Tan, JH
   Li, JX
   Xu, JE
   Tan, XY
   Zhai, JW
   Wu, JY
   Zhong, GH
   Li, MY
AF Liu, Guo-Hua
   Xu, Zhen-Yue
   Tan, Jian-Hui
   Li, Jia-xing
   Xu, Jun-Er
   Tan, Xiao-Yu
   Zhai, Jing-Wei
   Wu, Jia-yuan
   Zhong, Guo-Hui
   Li, Ming-Yi
TI Tapering-pressure VAC therapy for wound exudation in POPF after
   pancreatoduodenectomy: a single-center experience
SO FRONTIERS IN SURGERY
LA English
DT Article
DE postoperative pancreatic fistulas; open pancreaticoduodenectomy;
   laparoscopic pancreaticoduodenectomy; vacuum-assisted closure; wound
   exudation
ID INTERNATIONAL STUDY-GROUP; POSTOPERATIVE PANCREATIC FISTULA;
   PANCREATICOJEJUNOSTOMY; DEFINITION; PANCREATICOGASTROSTOMY; SURGERY;
   CLOSURE
AB Background Pancreaticoduodenectomy(PD) is the only effective treatment for the peri-ampullar carcinoma. However, postoperative pancreatic fistula(POPF) is the most intractable complication causing relevant mortality. Moreover, pancreatic juice may exude from the wound that would lead to more serious complications. Tapering pressure of wall vacuum-assisted closure (VAC) therapy is considered one of the best treatment to wound exudation. Here, we report on a single center series of 5 POPF cases accompanying wound exudation following open or Laparoscopic-assisted pancreatoduodenectomy, successfully managed by VAC.Methods We enrolled all patients who experienced POPF ensuing wound exudation following open or Laparoscopic-assisted pancreatoduodenectomy (OPD or LAPD) and received tapering pressure of vacuum-assisted closure (VAC) therapy between July 2017 and August 2024. For VAC, we utilized wall suction device devised by our center applying the technique of negative pressure wound therapy(NPWT). And we adjusted the tapering pressure of the abdominal wound wall vacuum which fixed to a 8Fr or 12Fr suction catheter and connected to the pressure regulator between -50 and -100 mmHg according to the wound exudation amount. When the amount of the wound exudation were less than 100 ml, the wall vacuum suction catheter could be connected to the negative pressure balloon so that the patients could be able to get out of bed. The wall vacuum of VAC was removed when the pancreatic fistula had sufficiently healed which resulting in complete wound healing.Results A total of 60 patients underwent OPD or LAPD. Among them, 9 had occured clinically related pancreatic fistulaI(CR-POPF)according to International Study Group on Pancreatic Fistula grade (POPF; 30%). one of the 3 grade C patients underwent Re-laparotomy due to the completely separated pancreaticojejunostomy and postoperative hemorrhage. 5 of the 6 grade B patients was performed tapering pressure of wall vacuum-assisted closure therapy for pancreatic juice exudation from the wound, and all of these patients had good outcomes by this VAC therapy.Conclusion Tapering pressure of wall VAC therapy could be a safe and effective treatment in the management of POPF ensuing wound exudation following open or Laparoscopic-assisted pancreatoduodenectomy. And this therapy may potentially reduce POPF-associated mortality.
C1 [Liu, Guo-Hua; Li, Ming-Yi] Jinan Univ, Inst Surg, Guangzhou, Guangdong, Peoples R China.
   [Liu, Guo-Hua; Xu, Zhen-Yue; Tan, Jian-Hui; Li, Jia-xing; Xu, Jun-Er; Tan, Xiao-Yu; Zhai, Jing-Wei; Wu, Jia-yuan; Zhong, Guo-Hui; Li, Ming-Yi] Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang, Guangdong, Peoples R China.
C3 Jinan University; Guangdong Medical University
RP Li, MY (通讯作者)，Jinan Univ, Inst Surg, Guangzhou, Guangdong, Peoples R China.; Li, MY (通讯作者)，Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang, Guangdong, Peoples R China.
EM limingyi63@163.com
FU Guangdong Medical University Clinical Research Program
FX We acknowledge Nian-Ping Chen, Chen Ming, Zhang Yi, and Xiao-Lu Liang,
   who contributed to the study by making substantial contributions to the
   acquisition of the data. All of them are involved in drafting the
   manuscript but do not meet the criteria for authorship.
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NR 24
TC 0
Z9 0
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JUL 10
PY 2025
VL 12
AR 1612420
DI 10.3389/fsurg.2025.1612420
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5EX7C
UT WOS:001534059100001
PM 40709063
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sabatakakis, A
   Fenske, J
   Lampert, P
   Kreiker, H
   Steffen, C
   Koerdt, S
   Doll, C
   Kreutzer, K
   Heiland, M
   Rendenbach, C
AF Sabatakakis, Antonis
   Fenske, Jakob
   Lampert, Philipp
   Kreiker, Henri
   Steffen, Claudius
   Koerdt, Steffen
   Doll, Christian
   Kreutzer, Kilian
   Heiland, Max
   Rendenbach, Carsten
TI Towards optimized donor site closure of radial forearm flaps: A cohort
   study of two techniques
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Free flap surgery; Radial forearm free flap; Maxillofacial
   reconstruction; Donor site complications; Tendon exposure; Negative
   pressure wound therapy
ID SKIN-GRAFT; NECK RECONSTRUCTION; MORBIDITY; HEAD
AB The radial forearm flap (RFF) is widely used for microvascular reconstruction in the head and neck region, but donor site complications, such as flexor tendon exposure, can impact patient recovery. This study retrospectively analyzed all patients who underwent RFF surgery between April 2017 and July 2023 to identify risk factors for donor site complications and compare the efficacy of two full-thickness skin graft (FTSG) designs: semilunar and VY/Dagger shaped. A matched-pair analysis was performed, and uni-and multivariate analyses were conducted to assess complication risks. Among 401 patients (178 females, mean age 67 +/- 12.4 years), 35 % experienced donor site complications. The semilunar FTSG design was identified as a predictor for flexor tendon exposure in both general (p = 0.03) and matched-pair analysis (p = 0.005). Negative pressure wound therapy (NPWT) did not demonstrate superior outcomes compared to conventional methods and was associated with an increased risk of partial graft necrosis (p = 0.03). These findings highlight the importance of FTSG design in RFF donor site closure, with the VY/Dagger shape demonstrating superior outcomes in reducing tendon exposure. Additionally, NPWT does not appear to provide significant benefits in preventing local complications and may not be preferable to conventional wound dressings. These results underscore the role of reflective surgical practice in improving patient outcomes.
C1 [Fenske, Jakob] Charite Univ Med Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
   Free Univ Berlin, Berlin, Germany.
   Humboldt Univ, Dept Oral & Maxillofacial Surg, Berlin, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Free University of Berlin; Humboldt
   University of Berlin
RP Fenske, J (通讯作者)，Charite Univ Med Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM jakob.fenske@charite.de
RI Fenske, Jakob/LLM-2561-2024; Rendenbach, Carsten/E-8384-2013; Heiland,
   Max/IUM-8981-2023; Steffen, Claudius/AAS-6626-2021; Doll,
   Christian/QMQ-3496-2026
OI Fenske, Jakob/0009-0000-3453-3903; Kreutzer, Kilian/0000-0003-0581-4137;
   Rendenbach, Carsten/0000-0002-9565-7640; Koerdt,
   Steffen/0000-0002-8679-8775; Heiland, Max/0000-0002-4987-2913; Kreiker,
   Henri/0000-0003-1935-3546; Steffen, Claudius/0000-0003-4221-4878;
   Lampert, Philipp/0009-0005-9392-728X
FU German Research Foundation (DFG) [RE 4803/1-1]
FX This research was funded by the German Research Foundation (DFG, RE
   4803/1-1) .
CR Al-Aroomi MA, 2024, PLAST RECONSTR SURG, V154, P650, DOI 10.1097/PRS.0000000000011022
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NR 32
TC 1
Z9 1
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD AUG
PY 2025
VL 53
IS 8
BP 1123
EP 1128
DI 10.1016/j.jcms.2025.04.005
EA AUG 2025
PG 6
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 5FY6D
UT WOS:001534762200002
PM 40324917
OA hybrid
DA 2026-07-24
ER
PT J
AU Petric, M
   Plevel, D
   Trsan, U
   Trotovsek, B
AF Petric, Miha
   Plevel, Danaja
   Trsan, Uros
   Trotovsek, Blaz
TI A Decade-Long Case Series Report on the Surgical Management of
   Complicated Umbilical Hernia in Patients with Decompensated Liver
   Cirrhosis Utilizing Incisional Negative Pressure Therapy
SO MEDICINA-LITHUANIA
LA English
DT Article
DE complicated umbilical hernia; liver cirrhosis; incisional negative
   pressure therapy
ID MELD; MORTALITY; REPAIR; MODEL
AB Background and Objectives. Umbilical hernia is particularly common among patients with liver cirrhosis, affecting about 20% of this group, compared to 3-8.5% in healthy individuals. This increased prevalence is mainly due to weakened abdominal fascia, elevated intra-abdominal pressure, and malnutrition. The rapid progression of umbilical hernias often leads to complications such as skin necrosis, perforation, and strangulation. Historically, patients with liver cirrhosis and complicated umbilical hernia have faced high morbidity and mortality rates. However, recent advancements in perioperative management, especially in controlling ascites, have improved outcomes in elective treatments. Despite these advancements, managing patients with decompensated liver cirrhosis and complicated umbilical hernia in emergency settings remain a significant surgical challenge. Materials and Methods: We conducted a retrospective review of patients treated for complicated umbilical hernia at the University Medical Centre Ljubljana from 2015 to 2024, using prospectively collected data. This analysis involved implementing hernioplasty combined with incisional negative pressure wound therapy (iNPWT) as part of the surgical protocol. The primary endpoint of our study was the rate of local complications, while the secondary endpoints included the rate of systemic complications and 90-day mortality. Results: We treated 28 consecutive patients with complicated umbilical hernia and liver cirrhosis. Local wound complications were observed in three (10.7%) patients. Systemic complications developed in 10 patients (35.7%). The median duration of hospitalization was 8 days (range: 5-29), and no readmissions were recorded within the 30-day period. Two (7.1%) patients died within 90 days. Conclusions: Our experience indicates that iNPWT, when combined with surgical repair, can be safely utilized, yielding outcomes comparable to elective hernia repairs, even in emergency contexts. Further randomized controlled trials are necessary to validate these findings and optimize treatment protocols.
C1 [Petric, Miha; Plevel, Danaja; Trsan, Uros; Trotovsek, Blaz] Univ Med Ctr Ljubljana, Dept Abdominal Surg, Ljubljana 1000, Slovenia.
   [Petric, Miha; Trotovsek, Blaz] Univ Ljubljana, Med Fac, Ljubljana 1000, Slovenia.
C3 University Medical Centre Ljubljana; University of Ljubljana
RP Petric, M (通讯作者)，Univ Med Ctr Ljubljana, Dept Abdominal Surg, Ljubljana 1000, Slovenia.; Petric, M (通讯作者)，Univ Ljubljana, Med Fac, Ljubljana 1000, Slovenia.
EM miha.petric@kclj.si; danaja.plevel@kclj.si; uros.trsan@kclj.si;
   blaz.trotovsek@kclj.si
RI Petric, Miha/NMJ-5615-2025
OI Petric, Miha/0000-0002-1002-4853
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NR 39
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JUL 12
PY 2025
VL 61
IS 7
AR 1262
DI 10.3390/medicina61071262
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5HF1R
UT WOS:001535614100001
PM 40731891
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Forcignano, E
   Verra, M
   Lo Secco, G
   Arezzo, A
AF Forcignano, Edoardo
   Verra, Mauro
   Lo Secco, Giacomo
   Arezzo, Alberto
TI Endoscopic Management of Anastomotic Insufficiencies in the Lower GI
   Tract
SO VISCERAL MEDICINE
LA English
DT Review
DE Anastomotic leakage; Colorectal surgery; Endoscopy; Postoperative
   complication; Endoscopic vacuum therapy; Suturing device
ID VACUUM-ASSISTED CLOSURE; LOW ANTERIOR RESECTION; SCOPE CLIP OTSC;
   COLORECTAL ANASTOMOSES; DEFUNCTIONING STOMA; LEAKAGE; CANCER; THERAPY;
   PERFORATIONS; EXPERIENCE
AB Background: Anastomotic leaks and fistulas are a feared and challenging postoperative complication in colorectal surgery. Traditionally managed with protective ileostomy and revisional surgery, less-invasive endoscopic approaches are increasingly being utilized. Summary: This article provides a comprehensive overview of current endoscopic treatment principles for managing anastomotic leaks after colorectal surgery. These approaches can be categorized into three main strategies: endoscopic negative pressure therapy - using negative pressure via polyurethane foam drains to promote wound healing and drain secretions; direct closure techniques - including endoscopic suturing systems (e.g., OverStitch) and clipping devices (e.g., over-the-scope clip) to approximate tissue and close defects; and vacuum stenting - a hybrid approach that combines negative pressure therapy with defect coverage using a covered self-expanding metal mesh stent (VAC-stent). Each method offers unique advantages depending on the leak characteristics and timing of detection. Early diagnosis and individualized treatment selection are critical to successful outcomes. Key Messages: Endoscopic treatment of anastomotic insufficiencies represents a minimally invasive, effective and safe alternative to traditional surgical interventions, particularly in clinically stable patients.
C1 [Forcignano, Edoardo; Verra, Mauro; Lo Secco, Giacomo; Arezzo, Alberto] Univ Turin, Dept Surg Sci, Turin, Italy.
C3 University of Turin
RP Forcignano, E (通讯作者)，Univ Turin, Dept Surg Sci, Turin, Italy.
EM e.forcignano@gmail.com
RI /AAD-3487-2020; Arezzo, Alberto/AAB-6552-2020; Forcignanò,
   Edoardo/AAO-3899-2020
OI Arezzo, Alberto/0000-0002-2110-4082; 
CR Abdalla S, 2020, DIS COLON RECTUM, V63, P371, DOI 10.1097/DCR.0000000000001560
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   Choi HK, 2006, DIS COLON RECTUM, V49, P1719, DOI 10.1007/s10350-006-0703-2
   Davis B, 2013, SURG CLIN N AM, V93, P61, DOI 10.1016/j.suc.2012.09.014
   de Lacy FB, 2022, BJS-BRIT J SURG, V109, P822, DOI 10.1093/bjs/znac158
   den Dulk M, 2009, BRIT J SURG, V96, P1066, DOI 10.1002/bjs.6694
   Donatelli G, 2021, SURG OBES RELAT DIS, V17, P1432, DOI 10.1016/j.soard.2021.03.013
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   Schiffmann L, 2019, THER ADV GASTROENTER, V12, DOI 10.1177/1756284819877606
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   Verra M, 2019, TECH GASTROINTEST EN, V21, P104, DOI 10.1016/j.tgie.2019.05.002
   Wang QY, 2022, MINIM INVASIV THER, V31, P825, DOI 10.1080/13645706.2021.2010218
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
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   Wiedenhagen R., Colorectal Dis, V5, P1
NR 48
TC 1
Z9 1
U1 1
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2297-4725
EI 2297-475X
J9 VISC MED
JI Visc. Med.
PD AUG
PY 2025
VL 41
IS 4
BP 191
EP 199
DI 10.1159/000547021
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 5IJ8A
UT WOS:001536410600001
PM 40688737
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Corturillo, G
   Jovanovic, M
   Rohleder, S
   Heydweiller, AC
   Muensterer, OJ
   Doll, D
   von Sochaczewski, CO
AF Corturillo, Giada
   Jovanovic, Marko
   Rohleder, Stephan
   Heydweiller, Andreas C.
   Muensterer, Oliver J.
   Doll, Dietrich
   von Sochaczewski, Christina Oetzmann
TI Practice patterns of paediatric surgeons on treating pilonidal sinus
   disease - a national survey study
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Pilonidal sinus disease; Child; Survey; Paediatric surgery; Germany
ID METHYLENE-BLUE; PREVALENCE; RECURRENCE; GERMANY; EXCISION
AB PurposePaediatric pilonidal sinus disease is considered a separate entity of disease due to differing recurrence dynamics. However, there are almost no data on real-world surgical care and practice patterns for children and adolescents. We therefore aimed to gather such data surveying a representative sample of German paediatric surgeons.MethodsSome 101 German paediatric surgical departments and surgeries with inpatient beds were surveyed for their surgical approach to paediatric pilonidal sinus disease. The survey included demographics, information on practice setting, as well as the primary and secondary approach to pilonidal disease and three virtual patient scenarios.ResultsA total of 40 institutions (33 departments and 7 office-based paediatric surgeons) responded (recall rate 40%). Of these, 18/40 reported performing 10-20, and 9/40 perform 5-10 pilonidal sinus operations annually. 17/39 respondents have less than 10% recurrences among their patient cohort and 15/39 operate on 11-20% recurrences among their patients. The most frequently reported surgical approach was excision and secondary closure with 17/39, followed by excision and vacuum-assisted closure (13/39), and pit-picking (12/39). Intraoperative use of blue dyes report 15/39 and 29/39 continue postoperative outpatient care at their institution. Acute pilonidal sinus with abscess is treated with a two-staged approach within four weeks by 15/39 while 11 institutions wait more than four weeks until definitive surgery. In recurrent cases, the majority of 20/39 does not switch their approach, while 13/39 switch to excision and secondary closure, and 11/39 switch to excision and vacuum-assisted closure.ConclusionGerman paediatric surgeons prefer traditional approaches to pilonidal sinus diseases, but pit-picking is frequently used. Neither the adult-based national guideline recommendations nor paediatric treatment algorithms have been widely implemented. The reasons for these deviations from recommendations and favouring traditional approaches remain unclear.
C1 [Corturillo, Giada; Heydweiller, Andreas C.; von Sochaczewski, Christina Oetzmann] Univ Klinikum Bonn, Sekt Kinderchirurg Chirurg Klin, Bonn, Germany.
   [Jovanovic, Marko] Univ Klinikum Bonn, Inst Digitale Med, Venusberg Campus 1, D-53127 Bonn, Germany.
   [Rohleder, Stephan] Univ Med Mainz, Klin & Poliklin Kinderchirurg, Mainz, Germany.
   [Heydweiller, Andreas C.] St Marien Hosp Bonn, Kinderchirurg Klin, Bonn, Germany.
   [Muensterer, Oliver J.] Klinikum Ludwig Maximilians Univ Munchen, Kinderchirurg Klin & Poliklin, Dr von Haunersches Kinderspital, Munich, Germany.
   [Doll, Dietrich] St Marienhosp Vechta, Klin Proktochirurg & Pilonidalsinus, Vechta, Germany.
C3 University of Bonn; University of Bonn; Johannes Gutenberg University of
   Mainz; St. Marien Hospital; University of Munich; St. Marien Hospital
RP von Sochaczewski, CO (通讯作者)，Univ Klinikum Bonn, Sekt Kinderchirurg Chirurg Klin, Bonn, Germany.
EM c.oetzmann@gmail.com
RI ; Muensterer, Oliver/G-3953-2013; Doll, med./H-6633-2019; Oetzmann von
   Sochaczewski, Christina/ABF-5826-2020
OI Heydweiller, Aneas/0000-0002-4542-8030; Muensterer,
   Oliver/0000-0003-2790-4395; Rohleder, Stephan/0000-0001-5632-0423;
   Jovanović, Marko/0000-0003-0522-1016; Oetzmann von Sochaczewski,
   Christina/0000-0002-3469-777X
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 72
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD JUL 28
PY 2025
VL 40
IS 1
AR 165
DI 10.1007/s00384-025-04959-x
PG 11
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 5KV9R
UT WOS:001538087000001
PM 40721961
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Wen, J
   Hu, XX
AF Wen, Jing
   Hu, Xinxin
TI Efficacy of skin flap transfer combined with negative pressure wound
   therapy in the management of complex pressure ulcers
SO JOURNAL OF DERMATOLOGICAL TREATMENT
LA English
DT Article
DE Debridement; negative pressure wound therapy; pressure ulcer; quality of
   life; repair; skin flap transfer; wound repair
ID VACUUM-ASSISTED CLOSURE
AB AimTo evaluate outcomes of adding skin-flap transfer to negative-pressure wound therapy (NPWT) for complex pressure ulcers. Methods and materialTwenty-nine patients (Aug 2018-Sep 2022) were divided into control (debridement + NPWT, n = 14) and observation (same plus flap transfer, n = 15). One-year follow-up compared healing rates, healing time, postoperative stay, total stay, cost, Zarit caregiver burden, SF-36 quality of life, complications and recurrence. ResultsHealing rates, healing time, postoperative stay, complications and recurrence did not differ (p > 0.05). Observation group had shorter total stay, lower costs, reduced caregiver burden and better SF-36 scores (p < 0.05). ConclusionsSkin-flap transfer combined with NPWT safely treats complex pressure ulcers, improving quality of life, reducing caregiver load and overall costs without increasing complications or recurrence.
C1 [Wen, Jing] Third Peoples Hosp Hefei, Dept Plast Surg, Hefei, Peoples R China.
   [Wen, Jing] Anhui Med Univ, Dept Plast Surg, Hefei Clin Coll 3, Hefei, Peoples R China.
   [Hu, Xinxin] Third Peoples Hosp Hefei, Dept Sci & Educ, Hefei, Peoples R China.
   [Hu, Xinxin] Anhui Med Univ, Dept Sci & Educ, Hefei Clin Coll 3, Hefei, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Hu, XX (通讯作者)，Third Peoples Hosp Hefei, Dept Sci & Educ, 204 Wangjiang East Rd, Hefei 230041, Peoples R China.
EM xinxinhuhxx@126.com
FU Open Project of Key Laboratory of Dermatology (Anhui Medical
   University), Ministry of Education Open Project [AYPYS2024-14]
FX This work was supported by the Open Project of Key Laboratory of
   Dermatology (Anhui Medical University), Ministry of Education Open
   Project [AYPYS2024-14].
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NR 29
TC 0
Z9 0
U1 3
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-6634
EI 1471-1753
J9 J DERMATOL TREAT
JI J. Dermatol. Treat.
PD DEC 31
PY 2025
VL 36
IS 1
AR 2537752
DI 10.1080/09546634.2025.2537752
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 5LP9W
UT WOS:001538608400001
PM 40719245
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ioannidis, O
   Anestiadou, E
   Zapsalis, K
   Siozos, K
   Kerasidou, O
   Symeonidis, S
   Bitsianis, S
   Pramateftakis, MG
   Kotidis, E
   Mantzoros, I
   Angelopoulos, K
   Driagka, B
   Cheva, A
   Angelopoulos, S
AF Ioannidis, Orestis
   Anestiadou, Elissavet
   Zapsalis, Konstantinos
   Siozos, Konstantinos
   Kerasidou, Ourania
   Symeonidis, Savvas
   Bitsianis, Stefanos
   Pramateftakis, Manousos-Georgios
   Kotidis, Efstathios
   Mantzoros, Ioannis
   Angelopoulos, Konstantinos
   Driagka, Barbara
   Cheva, Angeliki
   Angelopoulos, Stamatios
TI Tailored Negative Pressure Wound Therapy with instillation in diabetic,
   hypertensive, and obese patients-when guideline treatment is not enough:
   a case series and a proposal for the ANSWER score
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Surgical site infection; Diabetes; BMI; Obesity; Hypertension;
   Microangiopathy; Instillation; Negative pressure wound therapy; NPWTi-d;
   Postoperative soft-tissue defect
ID PROPYL BETAINE; BLOOD-FLOW; BIOFILMS; POLYHEXANIDE; POLIHEXANIDE;
   PENETRATION; MECHANISM; EFFICACY; GROWTH; DEPTH
AB Background Wound healing is challenging in cases of impaired microcirculation, leading to wound chronicity, decreased quality of life, and increased morbidity. Surgical site infections (SSIs) pose a significant challenge in diabetic, hypertensive, and obese patients due to impaired microcirculation. Negative pressure wound therapy (NPWT) is a widely used adjunct in wound management, but its optimal parameters in this subgroup remain uncertain. Tailored management is essential, taking into consideration tissue perfusion status and the potential benefit of novel strategies for tissue healing. Methods We report a case seires of three obese patients with diabetes mellitus type 2 and arterial hypertension who developed severe SSIs after abdominal surgery, with extended flap mobilization and were managed with tailored NPWT strategies, including lower negative pressures, NPWT with instillation and dwell time (NPWTi-d), reticulated open cell foam dressings with through holes (ROCF-CC), and ultrasonic-assisted wound debridement (UAW). Based on these cases, we propose the ANSWER score (tAilored Negative presSure Wound thErapy in micRoangiopathy) to optimize NPWT pressure settings. Results In Patient 1, NPWT using silver dressings was initiated at a continuous pressure of-125 mmHg, but after extended necrosis developed, the negative pressure was reduced to-50 mmHg. In Patients 2 and 3, a continuous NPWT was set at-50 mmHg, which is the lower value of the available negative pressure range for the system used, resulting in significantly fewer necrotic areas. Dressings were changed every 48-72 h and culture-directed antibiotics were administered to all patients. Our findings suggest that the use of NPWT remains a basic element in promoting acute and chronic wound healing. Innovative techniques such as NPWTi-d, ROCF-CC, and UAW debridement, combined with low negative pressure levels, may achieve optimal results in patients with microangiopathy. Microcirculation plays a crucial role in wound healing, since impaired healing and a low rate of tissue regeneration have been observed in patients with compromised tissue perfusion, such as patients with diabetes, obesity, or arterial hypertension. However, the use of NPWT in patients with microangiopathy and extensive tissue dissection at the default operating pressure of-125 mmHg may lead to further ischemic necrosis. Based on our case series, a clinical score (ANSWER score-tAilored Negative presSure Wound thErapy in micRoangiopathy) is proposed as a useful tool that reflects the ideal level of negative pressure for patients with impaired microcirculation. The ANSWER score assigns risk factors (obesity, arterial hypertension, diabetes) a point each, reducing NPWT pressure accordingly (-25 mmHg per point from-125 mmHg). Conclusions Tailored NPWT settings, based on the ANSWER score, may enhance wound healing outcomes in patients with microangiopathy. Further clinical studies are warranted to validate this approach.
C1 [Ioannidis, Orestis; Anestiadou, Elissavet; Zapsalis, Konstantinos; Siozos, Konstantinos; Kerasidou, Ourania; Symeonidis, Savvas; Bitsianis, Stefanos; Pramateftakis, Manousos-Georgios; Kotidis, Efstathios; Mantzoros, Ioannis; Angelopoulos, Konstantinos; Driagka, Barbara; Angelopoulos, Stamatios] Aristotle Univ Thessaloniki, Gen Hosp Thessaloniki G Papanikolaou, Dept Gen Surg 4, Thessaloniki 54124, Greece.
   [Cheva, Angeliki] Aristotle Univ Thessaloniki, Sch Med, Dept Pathol, Thessaloniki 54124, Greece.
C3 George Papanikolaou General Hospital of Thessaloniki; Aristotle
   University of Thessaloniki; Aristotle University of Thessaloniki
RP Ioannidis, O (通讯作者)，Aristotle Univ Thessaloniki, Gen Hosp Thessaloniki G Papanikolaou, Dept Gen Surg 4, Thessaloniki 54124, Greece.
EM telonakos@hotmail.com; elissavetxatz@gmail.com; konstzapsalis@yahoo.gr;
   kwstassiwzos@hotmail.gr; kerasidourania@yahoo.gr;
   simeonidissavvas@yahoo.com; sbitsiani@gmail.com;
   mpramateftakis@hotmail.com; skotidis@gmail.com; imanvol@gmail.com;
   kostaggelo@hotmail.com; valiadrg@gmail.com; antacheva@yahoo.gr;
   saggelopoulos@auth.gr
RI Cheva, Angeliki/HGB-6685-2022; Bitsianis, Stefanos/PLC-1440-2026
OI Bitsianis, Stefanos/0000-0001-8281-1189
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NR 63
TC 2
Z9 3
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JUL 31
PY 2025
VL 20
IS 1
AR 66
DI 10.1186/s13017-025-00605-7
PG 13
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 5PR6T
UT WOS:001541373400001
PM 40739263
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ding, HX
   Wang, WW
   Yuan, MY
   Tang, JJ
   Zhou, JH
   Pan, JS
AF Ding, Haixiang
   Wang, Wenwen
   Yuan, Mingyang
   Tang, Junjan
   Zhou, Jianhong
   Pan, Jingshi
TI Multidisciplinary management of severe open pelvic fracture with
   multiple organ injuries: A case report
SO MEDICINE
LA English
DT Article
DE case report; damage control surgery; multidisciplinary management; open
   pelvic fractures; staged surgical approach
AB Rationale:Open pelvic fractures represent severe traumatic injuries with mortality rates approaching 50%. Complex cases involving multiple organ injuries and massive hemorrhage pose significant challenges in clinical management. Despite advances in trauma care, comprehensive documentation of successful management strategies for severe open pelvic fractures with multiple complications remains limited.Patient concerns:A 36-year-old female presented with an open pelvic fracture following a motor vehicle collision, complicated by hemorrhagic shock (blood pressure 66/45 mm Hg), multiple organ injuries including bladder rupture and rectal damage, and an 18-cm open wound from the right groin to the anus with active bleeding.Diagnoses:Young and Burgess anterior-posterior compression III type pelvic fracture with vertical shear mechanism, bilateral internal iliac artery injuries, complete bladder and urethral rupture, and extensive perineal-rectal injuries.Interventions:The patient underwent multiple staged interventions including emergency arterial embolization and stenting, external pelvic fixation, bladder repair, sigmoid colostomy, serial wound debridements, negative pressure wound therapy, and final reconstruction with muscle flap transposition and skin grafting. Treatment required 148 days of hospitalization, including 22 days in intensive care unit.Outcomes:The patient achieved successful recovery with healed fractures and wounds, though requiring permanent colostomy and cystostomy. Rehabilitation enabled functional recovery and return to daily activities.Lessons:Successful management of complex open pelvic fractures requires prompt hemorrhage control through interventional procedures, implementation of damage control principles with staged surgical approaches, close multidisciplinary collaboration, and comprehensive wound care and infection management. This strategy can significantly improve survival outcomes in severe cases.
C1 [Ding, Haixiang; Yuan, Mingyang; Zhou, Jianhong; Pan, Jingshi] Jiangnan Univ, Dept Trauma Surg, Affiliated Hosp, 1000 Hefeng Rd, Wuxi 214000, Jiangsu, Peoples R China.
   [Wang, Wenwen] Wuxi Hlth Vocat Coll, Dept Pharm, Wuxi, Jiangsu, Peoples R China.
   [Tang, Junjan] Jiangnan Univ, Affiliated Hosp, Dept Vasc Surg, Wuxi, Jiangsu, Peoples R China.
C3 Jiangnan University; Jiangnan University
RP Pan, JS (通讯作者)，Jiangnan Univ, Dept Trauma Surg, Affiliated Hosp, 1000 Hefeng Rd, Wuxi 214000, Jiangsu, Peoples R China.
EM haixiangding001@gmail.com; 513279244@qq.com; 1562629313@qq.com;
   3943483632@qq.com; 1562629314@qq.com; jingshipan001@163.com
RI ding, haixiang/KZU-4960-2024
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NR 25
TC 1
Z9 2
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG 1
PY 2025
VL 104
IS 31
AR e43551
DI 10.1097/MD.0000000000043551
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5RH9M
UT WOS:001542477100009
PM 40760631
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mabe, L
   Bollero, N
   Olson, MM
AF Mabe, Lainie
   Bollero, Nancy
   Olson, Michelle M.
TI Office-Based Wound Care
SO SURGICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Wound healing; Dressings; Debridement; Negative pressure wound therapy;
   Wound infection; Leg ulcer; Peristomal wound; Ambulatory Care
ID LEG ULCERS; MANAGEMENT; DRESSINGS
AB Acute and chronic wounds commonly require outpatient management and surgeons are key members of the patient's care team, often tasked with directing the care plan. It is important not only to understand the issues affecting the healing of all wounds, but also to address the specific needs of the individual patient. Involving the patient and their family in the wound care plan can greatly improve the success of treatment. Standard dressings consist of layers including ointment, contact layer, absorbent layer, contouring layer, and securing layer. More challenging wounds, due to patient comorbidities, complications, or pathology, will often require adjuncts to this basic dressing care. This can be especially difficult in resource-limited environments due to the expense of novel dressing materials. While specialized wound care centers can be helpful in the successful management of complex chronic wounds, they are not readily available to every patient.
C1 [Mabe, Lainie; Olson, Michelle M.] Methodist Hlth Syst, Grad Med Educ Dept, 1441 N Beckley Ave, Dallas, TX 75203 USA.
   [Bollero, Nancy] Carle Hlth Syst, Eugene Greenberg Digest Hlth Inst, 611 W Pk St, Urbana, IL 61801 USA.
RP Olson, MM (通讯作者)，Methodist Hlth Syst, Grad Med Educ Dept, 1441 N Beckley Ave, Dallas, TX 75203 USA.
EM MichelleOlson@mhd.com
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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   World Union of Wound Healing Societies Consensus Document, 2018, Surgical wound dehiscence: improving prevention and outcomes
NR 29
TC 1
Z9 1
U1 1
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0039-6109
EI 1558-3171
J9 SURG CLIN N AM
JI Surg. Clin.-North Am.
PD AUG
PY 2025
VL 105
IS 4
BP 751
EP 762
DI 10.1016/j.suc.2025.03.012
EA AUG 2025
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5TN8G
UT WOS:001543987000007
PM 40581468
DA 2026-07-24
ER
PT J
AU Molska, M
   Wojciech, M
   Pieszko, K
   Ciesla, S
   Murawa, D
AF Molska, Maja
   Wojciech, Magdalena
   Pieszko, Karolina
   Ciesla, Slawomir
   Murawa, Dawid
TI Randomized controlled trial comparing single-use negative-pressure wound
   therapy (sNPWT) with standard dressings during tissue
   expander-to-implant exchanges. Assessment of risk factors for impaired
   wound healing and clinical indications for sNPWT
SO EJSO
LA English
DT Article
DE Breast reconstruction; sNPWT; Scar; Wound healing; Mathematical model;
   Variable selection
ID MASTECTOMY; COMPLICATIONS
AB Background: Breast reconstruction is a key step in the physical and social recovery of breast cancer patients. Optimal wound healing is crucial not only for aesthetic outcomes but also for the uninterrupted continuation of adjuvant oncologic therapy, which can significantly impact overall prognosis. Purpose: The study compared single-use negative pressure wound therapy (sNPWT) with standard dressings during the second stage of breast reconstruction - tissue expander-to-implant exchanges. Additionally, it aimed to identify factors associated with an increased risk of impaired wound healing and postoperative complications, to determine clinical conditions in which the prophylactic use of sNPWT is most beneficial. Methods: The study evaluated 38 women undergoing the second stage of two-stage breast reconstruction after unilateral mastectomy. Each patient received either sNPWT or a standard dressing postoperatively, with allocation randomized and independent of both physician and patient. Scar characteristics, including elasticity, temperature, healing, and appearance, were assessed. Results: A significant difference in skin elasticity in favor of sNPWT was observed after 7 days, while the most pronounced difference was seen after 6 months (mean 0.688 vs. 0.480). No significant differences were found in temperature. Visually, sNPWT-treated scars appeared narrower and less prominent. The mathematical model identified radiotherapy as the only factor significantly associated with poor healing (p-value = 0.025). Conclusion: Compared to standard dressings, sNPWT demonstrates clear advantages in improving scars' elasticity and aesthetic appearance. Its application significantly reduces postoperative complications, including the risk of implant loss, making it a valuable option in breast reconstruction.
C1 [Molska, Maja] Univ Hosp Zielona Gora, Clin Dept Gen & Oncol Surg, PL-65046 Zielona Gora, Poland.
   [Molska, Maja; Pieszko, Karolina; Murawa, Dawid] Univ Zielona Gora, Dept Surg & Oncol, Coll Med, PL-65046 Zielona Gora, Poland.
   [Wojciech, Magdalena] Univ Zielona Gora, Inst Math, Dept Appl Math, PL-65046 Zielona Gora, Poland.
   [Pieszko, Karolina] Hosp Nowa Sol, Dept Plast Surg & Burns, PL-67100 Nowa Sol, Poland.
   [Ciesla, Slawomir; Murawa, Dawid] Reg Hosp Poznan, Greater Poland Specialist Ctr, Gen Surg & Surg Oncol Dept, PL-60479 Poznan, Poland.
C3 University of Zielona Gora; University of Zielona Gora
RP Molska, M (通讯作者)，Univ Hosp Zielona Gora, Clin Dept Gen & Oncol Surg, PL-65046 Zielona Gora, Poland.
EM majaa.molska@gmail.com
RI Wojciech, Magda/ABB-5969-2021
FU Smith Nephew
FX The open access is supported by Smith & Nephew. Smith & Nephew played no
   part in the design or execution of the study. Data collection, analysis
   and writing of this thesis was also done independently.
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NR 35
TC 1
Z9 2
U1 2
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0748-7983
EI 1532-2157
J9 EJSO-EUR J SURG ONC
JI EJSO
PD OCT
PY 2025
VL 51
IS 10
AR 110355
DI 10.1016/j.ejso.2025.110355
EA AUG 2025
PG 7
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 5UB4F
UT WOS:001544342300003
PM 40752228
OA hybrid
DA 2026-07-24
ER
PT J
AU Luther, L
   Maxson, R
   Stinner, DJ
AF Luther, Lauren
   Maxson, Ridge
   Stinner, Daniel J.
TI Negative pressure wound therapy in resource-limited environments: Review
   and field guide
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Negative pressure wound therapy; military; soft tissue; disaster; wound
   care
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; DAKINS SOLUTION;
   INSTILLATION; MANAGEMENT; FOAM; EXPERIENCE; INJURIES; TRAUMA; POWDER
AB Negative pressure wound therapy (NPWT) has emerged as a valuable tool in the management of traumatic soft tissue injuries. Negative pressure wound therapy alters the local wound environment through a variety of mechanisms at both the macroscopic and microscopic level to reduce edema, stimulate angiogenesis, decrease bacterial burden, and promote healing. In battlefield or disaster response settings, NPWT offers additional advantages including reductions in dressing changes and the skilled personnel required to complete them, as well as less exposure to the surrounding environment and associated infection risk. Despite these potential benefits, NPWT use in the austere environment can be limited by logistical and financial constraints associated with commercially available NPWT products. A variety of effective, low-cost NPWT systems have been devised to overcome these barriers. This review summarizes the existing literature on improvised NPWT systems. It also presents a detailed list of potential substitutions for the fundamental NPWT components, as well as techniques for troubleshooting and augments to consider in special scenarios. We aim to provide a concise and practical field guide for construction of an improvised NPWT system to facilitate delivery of evidenced-based wound care in austere environments with infrastructure constraints.
C1 [Luther, Lauren; Maxson, Ridge; Stinner, Daniel J.] Vanderbilt Univ, Med Ctr, Dept Orthopaed Surg, Nashville, TN 37232 USA.
   [Stinner, Daniel J.] Blanchfield Army Community Hosp, Dept Orthopaed Surg, Ft Campbell, TN USA.
C3 Vanderbilt University
RP Stinner, DJ (通讯作者)，Vanderbilt Univ, Med Ctr, Div Trauma, Dept Orthopaed Surg, 1215 21st Ave South,Med Ctr East 4200, Nashville, TN 37232 USA.
EM lauren.luther@vumc.org; r.maxson@vumc.org; daniel.j.stinner@vumc.org
RI Stinner, Daniel/KSM-9513-2024
OI Stinner, Daniel/0000-0002-8981-6262
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NR 58
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD AUG
PY 2025
VL 99
IS 3S
SU 1
BP S143
EP S149
DI 10.1097/TA.0000000000004708
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 5VT0Y
UT WOS:001545486000011
PM 40539971
DA 2026-07-24
ER
PT J
AU He, S
   Tang, N
   Li, S
AF He, Si
   Tang, Na
   Li, Sha
TI Comparison of negative pressure wound therapy with conventional wound
   care in the treatment of sternal wound infection after cardiac surgery:
   A meta-analysis with trial sequential analysis
SO PLOS ONE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; CARDIOTHORACIC
   SURGERY; INCISION MANAGEMENT; PREVENTION; SYSTEM; BIAS
AB Background Negative pressure wound therapy (NPWT) has become a popular treatment option for sternal wound infection (SWI). However, it remains uncertain whether the therapeutic benefits of NPWT are superior to conventional wound care. This study aimed to systematically evaluate the therapeutic effects of NPWT on SWI compared to conventional wound care through meta-analysis. Methods A comprehensive search of PubMed, Web of Science, Embase, and the Cochrane Library databases was conducted from inception to April 29, 2024 for all potential studies. The pooling of dichotomous outcome data was achieved using relative risk (RR), with results presented within a 95% confidence interval (CI). We utilized the standard mean difference (SMD) and 95% CI for continuous outcomes. Heterogeneity test, publication bias assessment, sensitivity analysis, and trial sequential analysis (TSA) were conducted. Publication bias was detected through the Begg's and Egger's tests. Software R 4.3.1, Stata 12.0, and TSA v0.9.5.10 Beta software were utilized for all analyses. Results Out of 1832 articles identified, 10 were included in this study. The overall results revealed that NPWT significantly decreased the sternal wound reinfection (SWRI) rate (RR [95% CI] = 0.179 [0.099 to 0.323], 95% prediction interval [PI]: 0.082 to 0.442), in-hospital mortality (RR [95% CI] = 0.242 [0.149 to 0.394], 95% PI: 0.144 to 0.461), and shortened the length of intensive care unit (ICU) stay (SMD [95% CI] = -0.601 [-0.820 to -0.382], 95% PI: -1.317 to 0.128) compared with conventional wound care. There was no significant difference in length of hospital stay (SMD [95% CI] = -0.402 [-0.815 to 0.012], 95% PI: -1.801 to 0.998) and treatment duration (SMD [95% CI] = -0.398 [-1.646 to 0.849], 95% PI: -16.340 to 15.543) between the NPWT group and control group. Further subgroup analysis demonstrated the benefits of NPWT in shortening hospitalization length in the European population (p < 0.05). Conclusion The present evidence corroborates that the application of NPWT in the treatment of SWI after cardiac surgery effectively reduces the SWRI incidence and in-hospital mortality while shortening the length of ICU stay.
C1 [He, Si; Tang, Na; Li, Sha] Hunan Univ Chinese Med, Hosp Infect Management Dept, Changsha Stomatol Hosp, Stomatol Clin Coll, Changsha, Peoples R China.
C3 Hunan University of Chinese Medicine
RP Li, S (通讯作者)，Hunan Univ Chinese Med, Hosp Infect Management Dept, Changsha Stomatol Hosp, Stomatol Clin Coll, Changsha, Peoples R China.
EM 1192063955@qq.com
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NR 54
TC 1
Z9 2
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 7
PY 2025
VL 20
IS 8
AR e0328771
DI 10.1371/journal.pone.0328771
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 5XE7X
UT WOS:001546478300040
PM 40773424
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Molasy, B
   Frydrych, M
   Kuchcinski, R
   Gluszek, S
AF Molasy, Bartosz
   Frydrych, Mateusz
   Kuchcinski, Rafal
   Gluszek, Stanislaw
TI Combining Topical Oxygen and Negative-Pressure Wound Therapy: New
   Insights from a Pilot Study on Chronic Wound Treatment
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE chronic wounds; wound healing; combined therapy; topical oxygen therapy;
   negative-pressure wound therapy; biomarkers; thermography
ID TO-HEAL WOUNDS
AB Background: Chronic wounds are a growing clinical challenge due to their prolonged healing time and associated healthcare burden. Combined therapeutic approaches, including topical oxygen therapy (TOT) and negative-pressure wound therapy (NPWT), have shown promise in enhancing wound healing. This pilot exploratory study aimed to assess the clinical effectiveness of combined TOT and NPWT in chronic wound treatment and to explore the prognostic value of selected laboratory and thermographic markers. Methods: Eighteen patients with chronic wounds due to type 2 diabetes mellitus or chronic venous insufficiency were treated with either TOT alone (control group) or TOT combined with NPWT (intervention group). Wound characteristics, thermographic data, and laboratory parameters (NLR, MLR, PLR, CRP, and total protein) were collected at baseline and during therapy. The primary endpoints were the total treatment duration and complete wound closure. Statistical analyses were exploratory and used non-parametric tests, correlation analyses, and simple linear regression. Results: Ulcer duration was significantly associated with the wound surface area. Lower serum total protein levels correlated negatively with ulcer duration, wound size, and granulation tissue area. A significant reduction in treatment duration was observed in the intervention group compared to the controls. One strong correlation was found between MLR and peripheral wound temperature on day 7 in the control group. No significant group differences were observed in wound size or thermographic measures after one week of treatment. Conclusions: Combining TOT and NPWT may reduce treatment duration in chronic wound management. Selected laboratory and thermographic markers show promise as prognostic tools. These exploratory findings require confirmation in larger, randomized trials.
C1 [Molasy, Bartosz] Jan Kochanowski Univ, Med Coll, PL-25317 Kielce, Poland.
   [Molasy, Bartosz; Frydrych, Mateusz; Kuchcinski, Rafal] St Alexander Hosp, Dept Gen Surg, PL-25316 Kielce, Poland.
   [Gluszek, Stanislaw] Holy Cross Canc Ctr, Dept Surg Oncol, PL-25734 Kielce, Poland.
   [Gluszek, Stanislaw] Polish Acad Sci, Inst Genet & Anim Biotechnol, PL-05552 Magdalenka, Poland.
C3 Jan Kochanowski University; Polish Academy of Sciences
RP Molasy, B (通讯作者)，Jan Kochanowski Univ, Med Coll, PL-25317 Kielce, Poland.; Molasy, B (通讯作者)，St Alexander Hosp, Dept Gen Surg, PL-25316 Kielce, Poland.
EM bartosz.molasy@onet.pl; frydrychmf@gmail.com; rafalk007@tlen.pl;
   sgluszek@wp.pl
RI Gluszek, Stanislaw/S-3303-2019; Molasy, Bartosz/JTV-0243-2023
OI Gluszek, Stanislaw/0000-0001-7752-0459; Molasy,
   Bartosz/0000-0003-3396-6242
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NR 19
TC 2
Z9 2
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG 7
PY 2025
VL 14
IS 15
AR 5564
DI 10.3390/jcm14155564
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6AQ2A
UT WOS:001548816900001
PM 40807185
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Billner, M
   Breidung, D
   Karcz, K
   Promny, D
   Ehrl, D
AF Billner, Moritz
   Breidung, David
   Karcz, Konrad
   Promny, Dominik
   Ehrl, Denis
TI From Liposuction to Reconstruction: Interdisciplinary Management of
   Necrotising Fasciitis after Outpatient Liposuction in a Non-Specialist
   Setting
SO HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE
LA German
DT Article
DE freeflap; necrotising fasciitis; aesthetic surgery; freeflap;
   necrotising fasciitis; aesthetic surgery
AB This case report describes the clinical course of necrotising fasciitis as a serious complication following outpatient liposuction. The patient required extensive surgical procedures, including radical debridement, negative pressure wound therapy (NPWT) and multiple flaps to cover the extensive tissue defects, alongside prolonged intensive medical care. This case underscores the risks associated with aesthetic procedures and emphasises the importance of having such procedures performed exclusively by qualified and experienced specialists. This case also impressively demonstrates the importance of early diagnosis and interdisciplinary management.
C1 [Billner, Moritz; Breidung, David; Karcz, Konrad; Promny, Dominik; Ehrl, Denis] Paracelsus Med Privatuniv, Zentrum Schwerbrandverletzte, Klin Plast Wiederherstellende & Handchirurg, Klinikum Nurnberg Sud,Univ Klin, Breslauer Str 201, D-90471 Nurnberg, Germany.
   [Promny, Dominik] Univ Klinikum Erlangen, Plast & Handchirurg Klin, Erlangen, Germany.
   [Ehrl, Denis] Klinikum Univ Munchen, Abt Hand Plast & Asthet Chirurg, Munich, Germany.
C3 University of Erlangen Nuremberg; University of Munich
RP Billner, M (通讯作者)，Paracelsus Med Privatuniv, Zentrum Schwerbrandverletzte, Klin Plast Wiederherstellende & Handchirurg, Klinikum Nurnberg Sud,Univ Klin, Breslauer Str 201, D-90471 Nurnberg, Germany.
EM moritz.billner@klinikum-nuernberg.de
OI Billner, Moritz/0000-0003-3614-9600
CR Aljerian A, 2024, PLAST SURG-CHIR PLAS, V32, P19, DOI 10.1177/22925503221078693
   [Anonymous], 2017, Journal of surgical case reports, P2017
   Breidung D, 2024, PRS-GLOB OPEN, V12, DOI 10.1097/GOX.0000000000005773
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   Zargaran D, 2023, J PLAST RECONSTR AES, V86, P150, DOI 10.1016/j.bjps.2023.06.057
NR 14
TC 0
Z9 0
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0722-1819
EI 1439-3980
J9 HANDCHIR MIKROCHIR P
JI Handchir. Mikrochir. Plast. Chir.
PD AUG
PY 2025
VL 57
IS 04
BP 307
EP 311
DI 10.1055/a-2639-8914
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6BE2J
UT WOS:001549183900005
PM 40795866
DA 2026-07-24
ER
PT J
AU Su, JW
   Zhang, D
   Du, JC
   Xiao, RZ
   Liu, Z
   Li, YQ
   Zhou, HW
   Li, J
AF Su, Junwei
   Zhang, Dong
   Du, Jincheng
   Xiao, Ruozu
   Liu, Zhe
   Li, Yuqian
   Zhou, Haowei
   Li, Jing
TI The Efficacy of Negative Pressure Wound Therapy Combined with Topical
   Oxygen Therapy in Treating Chronic Refractory Wounds: A Systematic
   Review and Meta-Analysis
SO ADVANCES IN WOUND CARE
LA English
DT Review; Early Access
DE combined therapy; negative pressure wound therapy; topical oxygen
   therapy; chronic refractory wounds; meta-analysis
ID TISSUE OXYGENATION; RICH
AB Objective: To evaluate the clinical efficacy of negative pressure wound therapy (NPWT) combined with topical oxygen therapy (TOT) for chronic refractory wounds (CRWs), addressing potential hypoxia limitation of NPWT through oxygen supplementation, thereby offering an innovative therapeutic approach for CRWs. <br /> Approach: The study was performed according to the 2015 Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols statement. A comprehensive search was conducted in PubMed, Cochrane, Embase, Web of Science, CNKI, VIP, and Wanfang databases for randomized controlled trials (RCTs) on the treatment of CRWs with NPWT combined with TOT (inception to October 2024). Studies were screened based on predefined criteria, and data were extracted and assessed using RevMan 5.4. Meta-analysis, sensitivity analysis, and publication bias assessment were performed using Stata 15.0. <br /> Results: Eleven RCTs (844 patients) were included. Compared with NPWT, the combination therapy was associated with the following outcomes: increased healing rate (risk ratio [RR] = 1.51, 95% confidence interval [CI]: 1.36-1.69, I-2 = 18.1%), reduced time from debridement to skin grafting (mean difference [MD] = -2.82 days, 95% CI: -3.15 to -2.50, I-2 = 4%), shortened healing time (MD = -9.09 days, 95% CI: -11.98 to -6.20, I-2 = 91.2%), enhanced granulation coverage (MD = 7.56%, 95% CI: 6.09-9.03, I-2 = 0.0%), and decreased bacterial positivity (RR = 0.27, 95% CI: 0.18-0.41, I-2 = 0.0%). <br /> Innovation: This study provides evidence-based medical research supporting NPWT plus TOT as a synergistic strategy for CRWs. <br /> Conclusion: Combined therapy may offer benefits over NPWT alone in CRW treatment, suggesting a promising approach to improve healing outcomes.
C1 [Su, Junwei; Zhang, Dong; Du, Jincheng; Xiao, Ruozu; Liu, Zhe; Li, Yuqian; Zhou, Haowei; Li, Jing] Fourth Mil Med Univ, Tangdu Hosp, Dept Burn & Plast Surg, Xian, Peoples R China.
C3 Air Force Medical University
RP Zhou, HW; Li, J (通讯作者)，Fourth Mil Med Univ, Tangdu Hosp, Dept Burn & Plast Surg, Xian, Peoples R China.
EM zhw1213133955@126.com; jingle2015@163.com
RI Su, Junwei/ACU-7152-2022
FU Key Industrial Innovation Chain Project of Shaanxi Provincial Key
   Research and Development Plan Project [2022ZDLSF04-03]; Clinical Project
   at the Fourth Military Medical University [2024LC2420]
FX This work was supported by Key Industrial Innovation Chain Project of
   Shaanxi Provincial Key Research and Development Plan Project (No.
   2022ZDLSF04-03) and Clinical Project at the Fourth Military Medical
   University (No. 2024LC2420).
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NR 39
TC 1
Z9 1
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD 2025 AUG 13
PY 2025
DI 10.1177/21621918251366606
EA AUG 2025
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 6BE4R
UT WOS:001549189900001
PM 40796343
DA 2026-07-24
ER
PT J
AU Bashyal, RK
   Searle, R
   Nherera, LM
   Wright, A
AF Bashyal, Ravi K.
   Searle, Richard
   Nherera, Leo M.
   Wright, Adam
TI Effects of single-use negative pressure wound therapy on healthcare use:
   US analysis of a large claims database
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE cardiovascular; healthcare resource use; negative pressure wound
   therapy; orthopaedic; surgical site complications; wound; wound care;
   wound dressing; wound healing
ID INFECTIONS; METAANALYSIS; DEHISCENCE; PREDICTORS; COSTS
AB Objective: To assess the effect of two single-use negative pressure and surgical site complications (SSCs) after orthopaedic and cardiovascular surgery. Method: Patient data were collected from the US-based Premier Adult patients upon whom the -80mmHg or -125mmHg sNPWT device was used within predefined orthopaedic and cardiovascular surgical categories were included. The HCRU endpoints measured were index encounter length of stay (LoS), and cost at index encounter and at 30 and 90 days post-surgery. Clinical endpoints were also assessed. Results: The mean index encounter LoS, and mean cost at index admission and at 30 and 90 days post-surgery were all significantly lower when the -80mmHg device was used, compared with the -125mmHg device, across orthopaedic and cardiovascular wounds (all p<0.0001). The odds ratio (OR) for dehiscence (30 days) was significantly lower when the-80mmHg device was used versus the-125mmHg device in orthopaedic (OR: 0.361; p <= 0.05) and cardiovascular (OR: 0.422; p <= 0.01) wounds. Differences between the devices were not found in superficial and deep surgical site infections or seroma for either orthopaedic or cardiovascular incisions (p>0.05). Conclusion: The-80mmHg device was associated with significantly lower HCRU and likelihood of dehiscence after orthopaedic and cardiovascular surgery versus the-125mmHg device and there were no differences in other SSCs.
C1 [Bashyal, Ravi K.] Endeavor Hlth Orthoped Inst, Skokie, IL USA.
   [Searle, Richard; Nherera, Leo M.] Smith Nephew Inc, Global Hlth Econ & Outcomes Res, Data Analyt, Ft Worth, TX 76107 USA.
   [Wright, Adam] Plano Orthoped & Sports Med Ctr, Plano, TX USA.
C3 Smith & Nephew
RP Nherera, LM (通讯作者)，Smith Nephew Inc, Global Hlth Econ & Outcomes Res, Data Analyt, Ft Worth, TX 76107 USA.
EM Leo.Nherera@smith-nephew.com
FU Smith+Nephew, Inc.
FX The authors would like to thank Francesca Lewns and Maike Jager of
   Costello Medical, UK for medical writing support funded by Smith+Nephew,
   Inc. They also want to thank Julie Murdoch and Amanda Spitzer of
   Smith+Nephew, Inc. for interpreting the clinical surgical complication
   results.
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NR 53
TC 1
Z9 1
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2025
VL 34
IS 8
BP 555
EP 562
DI 10.12968/jowc.2024.0339
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 6DQ3V
UT WOS:001550856500001
PM 40801766
DA 2026-07-24
ER
PT J
AU Hansen, F
   Aldrich, A
   Dorneden, A
   Esce, A
   Spafford, M
   Syme, N
   Olson, G
   Boyd, N
AF Hansen, Frederick
   Aldrich, Abigale
   Dorneden, Ashley
   Esce, Antoinette
   Spafford, Michael
   Syme, Noah
   Olson, Garth
   Boyd, Nathan
TI Negative Pressure Wound Therapy: A Novel Technique for Treatment of
   Chylous Fistula After Neck Surgery
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chylous fistula; chyle leak; wound vac therapy; negative pressure wound
   therapy; postoperative complications; neck dissection
ID MANAGEMENT; OCTREOTIDE; DISSECTION
AB Objectives: Chylous fistula or "chyle leak" is a rare complication of head and neck surgery that can be exceedingly difficult to manage. Traditional treatments include pressure dressings, dietary modification, octreotide administration, closed suction drainage, and revision surgery. In 2017, the Otolaryngology team at the University of New Mexico Hospital (UNMH) began implementing negative pressure wound therapy (NPWT) in conjunction with traditional conservative measures to treat chylous fistula. From our initial experiences implementing NPWT, an optimized protocol was developed and is now routinely used to manage chyle leaks at our institution.Methods: A retrospective chart review was performed to identify all patients who were treated with negative pressure wound therapy at UNMH after undergoing neck surgery and developing a chylous fistula. These patients were compared to a control group of patients with chylous fistula who were treated with traditional approaches alone before NPWT was implemented at UNMH.Results: Twenty-six patients were treated with NPWT for their chyle leak after neck surgery, 10 as part of the original protocol (Protocol 1) and 16 under an improved methodology (Protocol 2). No instances of great vessel desiccation were observed in any patient treated with NPWT. Protocol 2 was found to significantly reduce hospital length of stay as well as to reduce the duration of octreotide administration, dietary modification, and drain device placement compared to the control group treated by historical methods.Conclusion: NPWT is a novel and effective treatment approach that can be used in addition to traditional treatment modalities to treat chylous fistulae after neck surgery.
C1 [Hansen, Frederick; Aldrich, Abigale] Univ New Mexico, Sch Med, Albuquerque, NM USA.
   [Dorneden, Ashley; Esce, Antoinette; Spafford, Michael; Syme, Noah; Olson, Garth; Boyd, Nathan] Univ New Mexico, Sch Med, Dept Surg, Otolaryngol Div, 2211 Lomas Blvd NE, Albuquerque, NM 87106 USA.
C3 University of New Mexico; University of New Mexico
RP Boyd, N (通讯作者)，Univ New Mexico, Sch Med, Dept Surg, Otolaryngol Div, 2211 Lomas Blvd NE, Albuquerque, NM 87106 USA.
EM nhboyd@salud.unm.edu
RI ; Esce, Antoinette/ACS-1479-2022
OI Esce, Antoinette/0000-0001-7637-9641; Syme, Noah/0000-0002-7953-1765;
   Alich, Abigale/0009-0006-2583-4169
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NR 17
TC 0
Z9 0
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-4894
EI 1943-572X
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2026
VL 135
IS 1
BP 59
EP 67
DI 10.1177/00034894251361983
EA AUG 2025
PG 9
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA T3845
UT WOS:001552298000001
PM 40826903
OA Bronze
DA 2026-07-24
ER
PT J
AU Wu, LJ
   Guan, HL
   Yan, J
   Zhang, HY
   Fang, Q
   Wen, BY
   Lin, KF
   Xu, ZR
AF Wu, Lijiao
   Guan, Hongling
   Yan, Jin
   Zhang, Hongyan
   Fang, Qiong
   Wen, Baoyu
   Lin, Kefeng
   Xu, Zhaorong
TI An integrated medical-care wound management strategy in patients with
   hard-to-heal lower extremity ulcers undergoing negative pressure wound
   therapy
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE chronic; hard-to-heal; negative pressure wound therapy; nursing;
   physicians; ulcers; wound; wound care; wound dressing; wound healing;
   wound healing; lower extremity ulcer; lower extremity ulcer; lower
   extremity ulcer; negative pressure wound therapy; nursing; physicians;
   ulcers; wound; wound care; wound dressing; wound healing
ID NURSE-PHYSICIAN COLLABORATION; COMMUNICATION; PERCEPTIONS
AB Objective: To explore the clinical effect of an integrated medical-care wound management strategy in nursing care for patients undergoing negative pressure wound therapy (NPWT) for hard-to-heal (chronic) lower extremity ulcers. Method: Patients admitted to Fujian Provincial Hospital, China, from January to December 2022 were assigned to either an experimental group or a control group. Patients in the experimental group received nursing care under the guidance of an integrated medical care wound management strategy, while patients in the control group received clinical primary nursing care. The differences between the two groups before and after NPWT with regards to wound condition, hospital length of stay (LoS), inflammation, pain, quality of life (QoL) and anxiety were analysed. Results: A total of 60 patients were included (30 in each group). Both groups showed wound contraction. The experimental group had significantly shorter wound healing times and LoS. Inflammation (measured by white blood cell counts and C-reactive protein levels) was reduced and pain was relieved in both groups. Physical function, role-physical, bodily pain, general health, vitality, mental health and anxiety after NPWT treatment were improved in both groups, while there were no significant differences in social functioning and roleemotional. The experimental group had significantly lower pain (as measured by numerical rating scale scores) and significantly better physical function, general health and mental health, and less bodily pain and anxiety than the control group, with statistically significant differences (p<0.05). Conclusion: The findings of this study showed that an integrated medical care wound management strategy for patients undergoing NPWT effectively promoted wound healing, reduced inflammation, alleviated pain, and improved the QoL of patients with hard-to-heal lower extremity ulcers, and deserves further research and promotion.
C1 [Wu, Lijiao; Guan, Hongling; Yan, Jin; Zhang, Hongyan; Fang, Qiong; Wen, Baoyu; Lin, Kefeng] Fujian Prov Hosp, Dept Orthoped Surg, South Branch, Fuzhou 350001, Peoples R China.
   [Wu, Lijiao; Guan, Hongling; Yan, Jin; Zhang, Hongyan; Fang, Qiong; Wen, Baoyu; Lin, Kefeng] Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China.
   [Xu, Zhaorong] Fujian Med Univ, Union Hosp, Burn & Wound Repair Dept, Fuzhou 350001, Peoples R China.
   [Xu, Zhaorong] Fujian Med Univ, Fujian Prov Key Lab Burn & Trauma, Union Hosp, Fuzhou 350001, Fujian, Peoples R China.
C3 Fujian Provincial Hospital; Fujian Medical University; Fujian Medical
   University; Fujian Medical University
RP Lin, KF (通讯作者)，Fujian Prov Hosp, Dept Orthoped Surg, South Branch, Fuzhou 350001, Peoples R China.; Lin, KF (通讯作者)，Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China.; Xu, ZR (通讯作者)，Fujian Med Univ, Union Hosp, Burn & Wound Repair Dept, Fuzhou 350001, Peoples R China.; Xu, ZR (通讯作者)，Fujian Med Univ, Fujian Prov Key Lab Burn & Trauma, Union Hosp, Fuzhou 350001, Fujian, Peoples R China.
EM kefenglin@foxmail.com; 234828306@qq.com
FU Fujian Provincial Key Laboratory of Burn and Trauma, China
FX This work was supported by the Fujian Provincial Key Laboratory of Burn
   and Trauma, China.
CR [Anonymous], 2010, Nursing's social policy statement: The essence of the profession, V3rd
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NR 27
TC 0
Z9 0
U1 3
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2025
VL 34
SU 8
BP xiii
EP xxi
DI 10.12968/jowc.2023.0148
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 6GL2L
UT WOS:001552761500001
PM 40810935
DA 2026-07-24
ER
PT J
AU Feier, CVI
   Gaborean, V
   Faur, IF
   Vonica, RC
   Faur, AM
   Rus, VI
   Dragan, BS
   Muntean, C
AF Feier, Catalin Vladut Ionut
   Gaborean, Vasile
   Faur, Ionut Flaviu
   Vonica, Razvan Constantin
   Faur, Alaviana Monique
   Rus, Vladut Iosif
   Dragan, Beniamin Sorin
   Muntean, Calin
TI A Systematic Review of Closed-Incision Negative-Pressure Wound Therapy
   for Hepato-Pancreato-Biliary Surgery: Updated Evidence, Context, and
   Clinical Implications
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE hepatectomy; surgical site infection; negative-pressure wound therapy;
   closed-incision; liver surgery; pancreatectomy
ID SURGICAL-SITE INFECTION; HIGH-RISK; PREVENTION
AB Background and Objectives: Postoperative pancreatic fistula and post-hepatectomy liver failure remain significant complications after HPB surgery; however, superficial surgical site infection (SSI) is the most frequent wound-related complication. Closed-incision negative-pressure wound therapy (ciNPWT) has been proposed to reduce superficial contamination, yet no liver-focused quantitative synthesis exists. We aimed to evaluate the effectiveness and safety of prophylactic ciNPWT after hepatopancreatobiliary (HPB) surgery. Methods: MEDLINE, Embase, and PubMed were searched from inception to 30 April 2025. Randomized and comparative observational studies that compared ciNPWT with conventional dressings after elective liver transplantation, hepatectomy, pancreatoduodenectomy, and liver resections were eligible. Two reviewers independently screened, extracted data, and assessed risk of bias (RoB-2/ROBINS-I). A random-effects Mantel-Haenszel model generated pooled risk ratios (RRs) for superficial SSI; secondary outcomes were reported descriptively. Results: Twelve studies (seven RCTs, five cohorts) encompassing 15,212 patients (3561 ciNPWT; 11,651 control) met the inclusion criteria. Device application lasted three to seven days in all trials. The pooled analysis demonstrated a 29% relative reduction in superficial SSI with ciNPWT (RR 0.71, 95% CI 0.63-0.79; p < 0.001) with negligible heterogeneity (I-2 0%). Absolute risk reduction ranged from 0% to 13%, correlating positively with the baseline control-group SSI rate. Deep/organ-space SSI (RR 0.93, 95% CI 0.79-1.09) and 90-day mortality (RR 0.94, 95% CI 0.69-1.28) were unaffected. Seven studies documented a 1- to 3-day shorter median length of stay; only two reached statistical significance. Device-related adverse events were rare (one seroma, no skin necrosis). Conclusions: Prophylactic ciNPWT safely reduces superficial SSI after high-risk HPB surgery, with the greatest absolute benefit when baseline SSI risk exceeds approximate to 10%. Its influence on deep infection and mortality is negligible.
C1 [Feier, Catalin Vladut Ionut] Victor Babes Univ Med & Pharm, Abdominal Surg & Phlebol Res Ctr, Timisoara 300041, Romania.
   [Feier, Catalin Vladut Ionut] Pius Brinzeu Clin Emergency Hosp, Surg Clin 1, Timisoara 300723, Romania.
   [Gaborean, Vasile] Victor Babes Univ Med & Pharm Timisoara, Thorac Surg Res Ctr, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Gaborean, Vasile] Victor Babes Univ Med & Pharm Timisoara, Dept Surg Semiol, Fac Med, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Faur, Ionut Flaviu] Timisoara Emergency Cty Hosp, IInd Surg Clin, Timisoara 300723, Romania.
   [Faur, Ionut Flaviu] Victor Babes Univ Med & Pharm Timisoara, Dept Gen Surg 10, Timisoara 300041, Romania.
   [Vonica, Razvan Constantin] Lucian Blaga Univ Sibiu, Fac Med, Preclin Dept, Sibiu 550169, Romania.
   [Vonica, Razvan Constantin] Elysee Hosp, Dept Oncol, Alba Iulia 510040, Romania.
   [Faur, Alaviana Monique; Rus, Vladut Iosif; Dragan, Beniamin Sorin] Victor Babes Univ Med & Pharm Timisoara, Fac Med, Timisoara 300041, Romania.
   [Muntean, Calin] Victor Babes Univ Med & Pharm Timisoara, Dept Funct Sci 3, Med Informat & Biostat, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Lucian Blaga University of Sibiu; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara
RP Gaborean, V (通讯作者)，Victor Babes Univ Med & Pharm Timisoara, Thorac Surg Res Ctr, Eftimie Murgu Sq 2, Timisoara 300041, Romania.; Gaborean, V (通讯作者)，Victor Babes Univ Med & Pharm Timisoara, Dept Surg Semiol, Fac Med, Eftimie Murgu Sq 2, Timisoara 300041, Romania.; Faur, IF (通讯作者)，Timisoara Emergency Cty Hosp, IInd Surg Clin, Timisoara 300723, Romania.; Faur, IF (通讯作者)，Victor Babes Univ Med & Pharm Timisoara, Dept Gen Surg 10, Timisoara 300041, Romania.
EM catalin.feier@umft.ro; vasile.gaborean@umft.ro; flaviu.faur@umft.ro;
   razvanconstantin.vonica@ulbsibiu.ro; alaviana.faur@student.umft.ro;
   iosif.rus@student.umft.ro; beniamin.dragan@student.umft.ro;
   cmuntean@umft.ro
RI Gaborean, Vasile/KMA-7364-2024; Feier, Catalin Vladut
   Ionut/LVS-1661-2024; Muntean, Calin/HHZ-8783-2022; Faur, Flaviu
   Ionuț/AAY-2592-2020; Vonica, Razvan/LZF-6780-2025
OI Gaborean, Vasile/0009-0000-8647-1003; Feier, Catalin Vladut
   Ionut/0000-0002-3277-1198; Muntean, Calin/0000-0002-0497-0405; Faur,
   Flaviu Ionuț/0000-0001-6451-7461; 
FU The "Victor Babes" University of Medicine and Pharmacy, Timisoara,
   Romania
FX The APC was funded by the "Victor Babes" University of Medicine and
   Pharmacy, Timisoara, Romania.
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NR 37
TC 7
Z9 7
U1 2
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL 22
PY 2025
VL 14
IS 15
AR 5191
DI 10.3390/jcm14155191
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6GL3D
UT WOS:001552763300001
PM 40806812
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Richter, F
   Ellrichmann, M
AF Richter, Florian
   Ellrichmann, Mark
TI Endoscopic Treatment of Anastomotic Leakage in the Upper
   Gastrointestinal Tract
SO VISCERAL MEDICINE
LA English
DT Review
DE Anastomotic leakage; Upper gastrointestinal tract; Endoscopy; Endoscopic
   vacuum therapy
ID VACUUM-ASSISTED CLOSURE; EXPANDABLE METAL STENTS; SCOPE CLIPPING DEVICE;
   MULTICENTER EXPERIENCE; ESOPHAGEAL RESECTION; MANAGEMENT; THERAPY;
   DRAINAGE; DEFECTS; COMPLICATIONS
AB Background: Anastomotic leakage (AL) in the upper gastrointestinal tract (uGIT) is a critical condition associated with high mortality and significant morbidity. Effective management requires prompt and specialized diagnostic and therapeutic interventions through an interdisciplinary approach. In current practice, surgical intervention is infrequent and typically reserved for cases of extensive damage. Close collaboration between radiology, endoscopy, and surgery is essential for optimal care. Endoscopic therapy is the primary modality for managing AI in the upper GIT. This review offers an overview of the most common endoscopic treatment strategies for AL in this region. Summary: Significant advancements have been made in the endoscopic management of AL in the uGIT in recent years. Endoscopic sutures and clips remain appropriate for smaller defects, but for larger leakages, endoscopic vacuum therapy (EVT) is gaining prominence over stent placement. Innovative approaches, such as vacuum stents and small diameter filmed drainage (FD), offer promising new therapeutic options for treating AL in the uGIT. Key Messages: (1) Endoscopy plays a pivotal role in the management of AL in the upper GIT. (2) A growing body of evidence supports EVT as superior to other modalities such as sutures, tissue sealants, or clips. Notably, EVT has a lower complication rate and higher healing success compared to stent therapy in AL treatment. (3) New endoscopic techniques, including the vacuum stent and FD, represent promising advancements in the treatment of AL.
C1 [Richter, Florian] Univ Med Ctr Schleswig Holstein UKSH, Dept Gen Visceral Thorac Transplantat & Paediat S, Campus Kiel, Kiel, Germany.
   [Ellrichmann, Mark] Univ Med Ctr Schleswig Holstein UKSH, Med Dept 1, Interdisciplinary Endoscopy, Campus Kiel, Kiel, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; University
   of Kiel; Schleswig Holstein University Hospital
RP Ellrichmann, M (通讯作者)，Univ Med Ctr Schleswig Holstein UKSH, Med Dept 1, Interdisciplinary Endoscopy, Campus Kiel, Kiel, Germany.
EM mark.ellrichmann@uksh.de
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   Sierzega M, 2010, BRIT J SURG, V97, P1035, DOI 10.1002/bjs.7038
   Struecker B, 2018, DIGEST SURG, V35, P419, DOI 10.1159/000480357
   Swinnen J, 2011, GASTROINTEST ENDOSC, V73, P890, DOI 10.1016/j.gie.2010.12.019
   Symonds C J, 1887, Br Med J, V1, P870
   Tavares G., 2021, Dis Esophagus, V34
   van Boeckel PGA, 2011, ALIMENT PHARM THER, V33, P1292, DOI 10.1111/j.1365-2036.2011.04663.x
   van Halsema EE, 2015, WORLD J GASTROENTERO, V21, P12468, DOI 10.3748/wjg.v21.i43.12468
   Vilallonga R, 2016, OBES SURG, V26, P1378, DOI 10.1007/s11695-015-1959-1
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
   Weidenhagen R, 2010, ANN THORAC SURG, V90, P1674, DOI 10.1016/j.athoracsur.2010.07.007
   Wichmann D, 2020, ENDOSCOPY, V52, P377, DOI 10.1055/a-1139-0772
   Yousaf M, 2004, DIS COLON RECTUM, V47, P1403, DOI 10.1007/s10350-004-0576-1
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NR 72
TC 0
Z9 0
U1 1
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2297-4725
EI 2297-475X
J9 VISC MED
JI Visc. Med.
PD AUG
PY 2025
VL 41
IS 4
BP 182
EP 190
DI 10.1159/000545485
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 6IR4A
UT WOS:001554286100001
PM 40376231
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Reese, MW
   Hogge, R
   Roess, B
   Hepner, J
   Luke, R
   Kabir, I
   Nguyen, T
   Snyder, K
   Heaton, J
   Rendel, R
   Martyak, M
AF Reese, Miles W.
   Hogge, Raymond
   Roess, Brendan
   Hepner, John
   Luke, Robert
   Kabir, Ishraq
   Nguyen, Tuan
   Snyder, Kristen
   Heaton, Julia
   Rendel, Ricardo
   Martyak, Michael
TI Incisional Negative Pressure Wound Therapy in Trauma Laparotomies and
   Rates of Superficial Surgical Site Infections
SO SURGICAL INFECTIONS
LA English
DT Article
DE incisional negative pressure wound therapy; superficial surgical site
   infections; trauma laparotomies
ID VACUUM-ASSISTED CLOSURE
AB Objectives: Investigate the relationship between incisional negative pressure wound therapy (iNPWT) and the development of superficial surgical site infections (SSIs) and wound dehiscence. Methods: A retrospective chart analysis was performed. Trauma patients between the ages of 18 and 89 years receiving an emergent exploratory laparotomy on admission between January 1, 2015, and March 31, 2022, were included. A multivariable analysis was performed. The primary and secondary outcomes were the development of superficial SSI and wound dehiscence, respectively, on the basis of the type of incision closure. Results: Two hundred forty-seven patients who met our criteria were analyzed. Of these, 135 patients were closed with staples plus iNPWT, and 112 patients were closed with only staples. The multivariable analysis found decreased odds of superficial SSI in patients who received staples plus iNPWT versus staples alone (odds ratio [OR] = 0.28, p = 0.019). The multivariable analysis found decreased odds of wound dehiscence in patients who received staples plus iNPWT versus staples alone (OR = 0.24, p = 0.001). Conclusion: Our study revealed a statistically significant decreased odds of superficial SSI and wound dehiscence in patients who received staples plus iNPWT when compared with staples alone.
C1 [Reese, Miles W.; Hogge, Raymond; Roess, Brendan; Hepner, John; Luke, Robert; Kabir, Ishraq; Nguyen, Tuan; Snyder, Kristen; Heaton, Julia; Rendel, Ricardo; Martyak, Michael] Old Dominion Univ, Macon & Joan Brock Virginia Hlth Sci, Eastern Virginia Med Sch, Dept Surg, 825 Fairfax Ave 610, Norfolk, VA 23507 USA.
C3 Eastern Virginia Medical School; Old Dominion University
RP Reese, MW (通讯作者)，Old Dominion Univ, Macon & Joan Brock Virginia Hlth Sci, Eastern Virginia Med Sch, Dept Surg, 825 Fairfax Ave 610, Norfolk, VA 23507 USA.
EM mreese.surg@gmail.com
CR ACELITY, 2023, PREVENATM INCISION M
   Atherton K, 2025, JAMA-J AM MED ASSOC, V333, P853, DOI 10.1001/jama.2024.24764
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   Rafaqat W, 2024, AM J SURG, V228, P287, DOI 10.1016/j.amjsurg.2023.10.055
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   Schurtz E, 2018, AM J SURG, V215, P113, DOI 10.1016/j.amjsurg.2017.08.009
   Zimlichman E, 2013, JAMA INTERN MED, V173, P2039, DOI 10.1001/jamainternmed.2013.9763
NR 17
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD NOV 1
PY 2025
VL 26
IS 9
BP 702
EP 706
DI 10.1177/10962964251370931
EA AUG 2025
PG 5
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA 9LQ4O
UT WOS:001554688300001
PM 40836825
DA 2026-07-24
ER
PT J
AU Li, XM
   Li, R
   Luo, XL
   Chen, T
   Wu, J
AF Li, Xiaomin
   Li, Rui
   Luo, Xiangli
   Chen, Teng
   Wu, Jian
TI Giant Morel-Lavallée lesion complicated with open pelvic fracture: a
   rare case report
SO FRONTIERS IN SURGERY
LA English
DT Article
DE Morel-Lavall & eacute;e lesion; open pelvic fracture; misdiagnosis; case
   report; rare
ID MOREL-LAVALLEE LESION; CLINICAL PRESENTATION; MANAGEMENT; DRAINAGE
AB Background Morel-Lavall & eacute;e lesion (MLL) is a rare closed degloving injury from high-energy shear/crush trauma, often linked to pelvic/acetabular fractures. Due to limited clinical awareness, it is highly prone to misdiagnosis, potentially causing severe complications like infection and skin necrosis. Existing literature rarely documents giant MLL with open pelvic fractures. This article reports such a case in an obese patient after heavy-object impact, aiming to enhance understanding and improve management of complex injuries.Case presentation A 27-year-old male sustained lumbosacral giant MLL and open pelvic fracture from workplace heavy-object crush. The MLL was unrecognized for two weeks at another hospital. Upon transfer, he had hemorrhagic shock, fluctuating lumbosacral swelling, and localized skin necrosis. Imaging showed comminuted left iliac fracture with extensive soft tissue edema and gas.Management A three-stage surgery was used. Stage 1: muscle debridement, fracture fixation, and vacuum-assisted closure (VAC) to address acute injury and control infection. Stage 2: debridement, antibiotic-loaded bone cement implantation, and continued VAC for osteomyelitis treatment and bone healing. Stage 3: flap reconstruction and skin grafting to restore soft tissue integrity.Outcome The patient was discharged one month postoperatively with viable skin grafts. At 3-month follow-up, fracture and wound healed well, confirming the staged approach's effectiveness.Conclusion MLL is often overlooked in high-energy trauma, emphasizing early comprehensive exams plus imaging to avoid misdiagnosis. For MLL with fractures, staged treatment is advisable: early radical debridement and VAC to control infection, followed by fixation and soft tissue reconstruction when stable. VAC reduces infection risk by minimizing exudation and promoting granulation. Obese patients, with loose adipose compartments, face higher MLL risk and need special attention. Future research should explore minimally invasive techniques to optimize outcomes.
C1 [Li, Xiaomin; Li, Rui] China Acad Chinese Med Sci, Wangjing Hosp, Dept Orthoped, Beijing, Peoples R China.
   [Luo, Xiangli; Wu, Jian] Gansu Prov Peoples Hosp, Dept Orthoped, Lanzhou, Peoples R China.
   [Chen, Teng] Gansu Univ Chinese Med, Dept Endocrinol, Affiliated Hosp, Lanzhou, Peoples R China.
C3 Wang Jing Hospital, CACMS; China Academy of Chinese Medical Sciences;
   Gansu University of Chinese Medicine
RP Luo, XL (通讯作者)，Gansu Prov Peoples Hosp, Dept Orthoped, Lanzhou, Peoples R China.
EM liuang1997@126.com
RI LI, RUI/NQF-9317-2025
OI Li, Xiaomin/0000-0003-3094-1816
FU Gansu Provincial Science and Technology Plan Project; Wangjing Hospital
   of China Academy of Chinese Medical Sciences and Gansu Provincial
   People's Hospital
FX The authors would like to thank Wangjing Hospital of China Academy of
   Chinese Medical Sciences and Gansu Provincial People's Hospital for
   their surgical guidance and assistance. Special thanks also go to
   Professor Jian Wu for the financial support.
CR Agha RA, 2020, INT J SURG, V84, P231, DOI 10.1016/j.ijsu.2020.11.005
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NR 28
TC 0
Z9 1
U1 2
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD AUG 12
PY 2025
VL 12
AR 1639073
DI 10.3389/fsurg.2025.1639073
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6LQ6P
UT WOS:001556307200001
PM 40874241
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gamel, M
   Gael, M
   Bursztejn, AC
AF Gamel, M.
   Gael, M.
   Bursztejn, A. C.
TI Skin graft bolstered by negative pressure therapy in chronic wounds: A
   systematic review
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Review
DE chronic wounds; negative pressure wound therapy; skin graft
ID VACUUM-ASSISTED CLOSURE; CHRONIC LEG ULCERS; BED PREPARATION; TRIAL;
   INSTILLATION; MANAGEMENT; DEVICE
AB Background Chronic ulcers represent a significant burden for patients, often requiring advanced therapeutic interventions. Skin grafting is a critical treatment option, yet the risk of graft failure remains substantial. Negative pressure wound therapy (NPWT) has demonstrated efficacy in enhancing graft survival in acute wounds, but its effectiveness in chronic ulcers remains underexplored.Objective This systematic review aimed to evaluate the efficacy of NPWT in bolstering skin grafts for the treatment of chronic ulcers.Methods We conducted this systematic literature review using the scientific databases PUBMED, COCHRANE and EMBASE. Studies involving skin grafts supported by NPWT for chronic wounds were included, while those focussing on acute wounds, burns or post-surgical wounds were excluded. Data on patient demographics, wound characteristics, NPWT parameters and graft outcomes were extracted and analysed.Results A total of 21 articles, encompassing 186 patients, were included. The maximal graft uptake (>= 95%) was observed in 33% of patients, while 77% achieved a graft uptake of >= 90%. The mean graft take was 92% (89.7, 93.5, 95% confidence interval). Complete recovery was achieved in 79% of patients, with a mean recovery time of 73 days. Complete response without recurrence was noticed in 38% of the cases, with a mean time without recurrence of 197 days. Exploratory analyses indicated higher graft take rates in patients under 65 years, males, diabetics and those without arterial disease. Venous and neurotrophic ulcers also showed superior graft uptake.Conclusion NPWT appears to significantly enhance graft survival in chronic ulcers, with an excellent safety and tolerance profile. As there was no control group, historical controls of graft take without NPWT were used. Short-term NPWT application (less than 1 week) is recommended for optimal outcomes. These findings suggest that NPWT should be considered a preferred method for securing skin grafts in chronic ulcer management.
C1 [Gamel, M.; Gael, M.; Bursztejn, A. C.] Ctr Hosp Univ Nancy, Batiment P Canton, Dermatol, Vandoeuvre les Nancy, France.
C3 CHU de Nancy
RP Bursztejn, AC (通讯作者)，CHRU Nancy, Dermatol & Allergol Dept, Batiment Philippe Canton, Rue Morvan, F-54500 Vandoeuvre les Nancy, France.
EM ac.bursztejn@chru-nancy.fr
OI GAMEL, Mélina/0009-0006-8432-4505
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   Zhang LP, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/8824737
NR 37
TC 3
Z9 4
U1 3
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD FEB
PY 2026
VL 40
IS 2
BP 296
EP 304
DI 10.1111/jdv.20808
EA AUG 2025
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DC5FK
UT WOS:001557061600001
PM 40862371
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Dynarska, J
   Zagrodnik, E
   Kisielska, A
   Jurczak, A
   Machalowski, T
   Wieder-Huszla, S
AF Dynarska, Jolanta
   Zagrodnik, Edyta
   Kisielska, Agnieszka
   Jurczak, Anna
   Machalowski, Tomasz
   Wieder-Huszla, Sylwia
TI The Use of Larval Debridement Therapy and Negative-Pressure Wound
   Therapy for an Infected Wound After Thyroidectomy-A Case Report
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE larval debridement therapy; fistula; healing; wound; necrotic tissue;
   wound therapy
ID MAGGOT
AB Background: Larval debridement therapy is used to cleanse necrotic tissue wounds and/or decontaminate wounds that are not amenable to standard therapies. Methods: A patient was diagnosed with septic shock and multiple organ failure caused by Streptococcus pyogenes after thyroidectomy (the patient had experienced contact with a child with scarlet fever six days before admission to the hospital). As a result of systemic infection, numerous necrotic skin lesions appeared, which involved the surgical site, chest and scalp. A tracheocutaneous fistula was confirmed. Due to the ineffectiveness of typical therapy and the patient's severe clinical condition, she qualified for unconventional therapy (larval debridement therapy). Results: Larval wound debridement therapy and negative-pressure wound therapy were used for the tracheocutaneous fistula; this is the first case of this alternative therapy being described in the English-language literature. In this case, based on an analysis of the health benefits for the patient and the uncertain prognosis, larval therapy was used for a postoperative wound after strumectomy with the presence of a tracheocutaneous fistula, and negative-pressure wound therapy ultimately led to complete wound healing. Conclusions: Sepsis caused by Streptococcus pyogenes can be fulminant and often leads to complications or death, especially if it develops in the perioperative period. Larval therapy can be effectively used in cases of fistulas, such as tracheocutaneous fistulas, to prepare the wound bed for the next stage of healing using negative-pressure therapy, which ultimately leads to complete wound healing.
C1 [Dynarska, Jolanta; Kisielska, Agnieszka] Med Ctr Jolanta Dynarska, PL-70953 Szczecin, Poland.
   [Zagrodnik, Edyta] Pomeranian Med Univ, Clin Dept Anesthesiol & Intens Care Adults & Child, PL-71252 Szczecin, Poland.
   [Jurczak, Anna; Wieder-Huszla, Sylwia] Pomeranian Med Univ, Dept Specialized Nursing, PL-71210 Szczecin, Poland.
   [Machalowski, Tomasz] Pomeranian Med Univ, Dept Perinatol Obstet & Gynecol, PL-71252 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University
RP Zagrodnik, E (通讯作者)，Pomeranian Med Univ, Clin Dept Anesthesiol & Intens Care Adults & Child, PL-71252 Szczecin, Poland.; Machalowski, T (通讯作者)，Pomeranian Med Univ, Dept Perinatol Obstet & Gynecol, PL-71252 Szczecin, Poland.
EM rejestracja@dynarska-centrum.pl; edyta.zagrodnik@pum.edu.pl;
   szpital@onkologia.szczecin.pl; anna.jurczak@pum.edu.pl;
   tomasz.machalowski@pum.edu.pl; sylwia.wieder.huszla@pum.edu.pl
RI Huszla, Sylwia/GQR-0700-2022; Jurczak, Anna/K-8913-2014; Machałowski,
   Tomasz/MDT-3268-2025
OI Jurczak, Anna/0000-0003-1935-5285; Kisielska, Agnieszka
   Katarzyna/0009-0002-0649-7575; Machałowski, Tomasz/0000-0001-6595-8250
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG 9
PY 2025
VL 14
IS 16
AR 5634
DI 10.3390/jcm14165634
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6NV6L
UT WOS:001557798800001
PM 40869460
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pandey, V
   Mishra, SP
   Kaushik, MB
   Khobragade, M
   Gaur, SKS
   Nandan, R
AF Pandey, Vaibhav
   Mishra, Shashi Prakash
   Kaushik, Marripati Bhanumurthy
   Khobragade, Manish
   Gaur, Sunil Kumar Singh
   Nandan, Ruchira
TI Outcomes of vacuum-assisted and conventional wound management in
   pediatric abdominal surgery: A retrospective study from a
   resource-limited setting
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Pediatric wound manager; Pediatric complex wounds; VAC in pediatric
   patients; Traditional wound management vs. newer techniques in pediatric
   patients; Negative pressure wound therapy
ID NEGATIVE-PRESSURE THERAPY; CLOSURE; INFANTS
AB Background: Complicated abdominal wounds following pediatric laparotomy, particularly in cases of enterocutaneous fistulae, trauma, or re-exploration, present significant management challenges, especially in resource-limited settings. Despite evidence supporting vacuum-assisted closure (VAC) therapy in adults, its use in pediatric populations remains limited. Aim: This study aimed to evaluate and compare the outcomes of vacuum-assisted and conventional wound management techniques in pediatric abdominal surgery within a resource-constrained environment. Methods: A retrospective observational study was conducted at a tertiary pediatric surgical centre in Northern India from January 2016 to December 2024. A total of 43 children (0-18 years) with complicated postoperative abdominal wounds were included. Patients were divided into two groups: Group 1 (n = 19) underwent traditional wound closure, while Group 2 (n = 24) received wound management using VAC therapy or simple wound manager systems. Primary outcomes were time to wound healing and incidence of wound-related complications. Secondary outcomes included hospital stay, re-exploration, and spontaneous fistula closure. Results: The wound manager group showed a slightly longer median healing time (15 vs. 12 days) but had zero re-explorations compared to three cases in the traditional group (p = 0.0011). VAC therapy led to earlier granulation (median 6 vs. 10 days), greater complete epithelialization (80 % vs. 40 %, p = 0.04), and spontaneous closure in 20 % of enterocutaneous fistulas. Four patients continued VAC therapy at home without complications. Conclusion: VAC and simple wound manager systems are effective in managing complex pediatric abdominal wounds, reducing the need for reoperation and enhancing healing outcomes. Their adoption in low-resource settings could significantly improve pediatric surgical care. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Pandey, Vaibhav; Kaushik, Marripati Bhanumurthy; Khobragade, Manish; Gaur, Sunil Kumar Singh; Nandan, Ruchira] IMS BHU, Dept Pediat Surg, Varanasi 221005, Uttar Pradesh, India.
   [Mishra, Shashi Prakash] IMS BHU, Dept Gen Surg, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Banaras Hindu University (BHU)
RP Nandan, R (通讯作者)，Atal Bihari Vajpayee Inst Med Sci & Dr Ram Manohar, Dept Pediat Surg, New Delhi, India.
EM ruchira.nandan@gmail.com
RI Nandan, Ruchira/ADG-3155-2022; /AAR-7896-2020
OI Nandan, Ruchira/0000-0002-1563-7771; Marripati, Bhanumurthy
   Kaushik/0000-0001-8448-7984
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD OCT
PY 2025
VL 60
IS 10
AR 162495
DI 10.1016/j.jpedsurg.2025.162495
EA AUG 2025
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 6PF9X
UT WOS:001558746500001
PM 40749973
DA 2026-07-24
ER
PT J
AU Zhang, G
   Pan, JL
   Wan, SY
   Chang, ZQ
AF Zhang, Ge
   Pan, Junlin
   Wan, Shiyong
   Chang, Zhengqi
TI Exploring hemorrhagic shock as a complication of negative pressure wound
   therapy in the treatment of lumbar spine infection: a case study and
   literature review
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE negative pressure wound therapy technology; lumbar infectious diseases;
   Brucella; complications; hemorrhagic shock
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Lumbar infectious diseases are serious debilitating conditions, and their treatment poses significant challenges. With the advancement of minimally invasive spinal techniques, negative pressure wound therapy (NPWT) has been widely recognized as an effective method for preventing and treating infected wounds. However, studies specifically focusing on hemorrhagic shock as a complication of NPWT in lumbar spine infections are limited. Here, we present a case of hemorrhagic shock as a postoperative complication of Brucella infection in the lumbar spine, and summarize the management of postoperative complications of lumbar infectious diseases treated with NPWT.
C1 [Zhang, Ge; Chang, Zhengqi] 960th Hosp PLA, Dept Orthopaed, Jinan, Peoples R China.
   [Pan, Junlin] 960th Hosp PLA, Dept Reprod Med, Jinan, Peoples R China.
   [Wan, Shiyong] 961th Hosp PLA, Dept Orthoped, Qiqihar, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthopaed, Jinan, Peoples R China.
EM 26766771@qq.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 19
TC 0
Z9 0
U1 1
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD AUG 14
PY 2025
VL 12
AR 1602481
DI 10.3389/fmed.2025.1602481
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6PZ7W
UT WOS:001559262900001
PM 40893874
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Acosta, J
   Galarza, L
   Marsh, M
   Martinez, RR
   Eells, M
   Collinsworth, AW
AF Acosta, Julie
   Galarza, Lydia
   Marsh, Margaret
   Martinez, Ricardo R.
   Eells, Mark
   Collinsworth, Ashley W.
TI Effectiveness of Negative Pressure Wound Therapy With Instillation and
   Dwell in Removing Nonviable Tissue, Promoting Granulation Tissue, and
   Reducing Surgical Debridements: A Systematic Literature Review
SO WOUND REPAIR AND REGENERATION
LA English
DT Review
DE debridement; negative pressure wound therapy with instillation; wound
   cleansing; wound treatment
ID OPEN-CELL FOAM; EARLY-STAGE MANAGEMENT; HOLES; TIME
AB Surgical debridement is a common treatment for complex wounds but can present risks for patients. Negative pressure wound therapy with instillation and dwell (NPWTi-d) using reticulated open cell foam dressings with 1 cm holes (ROCF-CC) provides hydromechanical wound cleaning and preparation and can be applied outside the operating room at the bedside. This systematic literature review examined the effectiveness of NPWTi-d with ROCF-CC in removing nonviable tissue and infectious material, promoting granulation tissue, and reducing surgical debridements. A systematic search was conducted utilising PubMed, Embase, and ClinicalTrials.gov to identify studies conducted from 1 January 2015-31 August 2022. Study outcomes related to nonviable tissue, granulation tissue, and debridement were summarised and analysed using descriptive statistics. Twenty-one studies including 178 patients who received NPWTi-d with ROCF-CC were included. Evidence of reduction in necrotic and infected tissue following treatment was observed in 97.9% of wounds across 17 studies. Formation of granulation tissue after NPWTi-d with ROCF-CC was reported in 99.2% of wounds across 14 studies. Over 63% of patients avoided surgical debridements in 8 studies, and a statistically significant decrease in surgical debridements was noted in 2 comparative studies. This systematic review provides real-world evidence demonstrating the effectiveness of NPWTi-d with ROCF-CC in the hydromechanical removal of infectious materials, non-viable tissue, and wound debris; reduction of surgical debridements; and promotion of granulation tissue. Thus, NPWTi-d with ROCF-CC may potentially reduce or eliminate the need for surgical debridement by removing non-viable tissue through hydromechanical action.
C1 [Acosta, Julie; Galarza, Lydia; Marsh, Margaret; Martinez, Ricardo R.; Eells, Mark; Collinsworth, Ashley W.] Solventum, Med Surg, Maplewood, MN 55144 USA.
RP Collinsworth, AW (通讯作者)，Solventum, Med Surg, Maplewood, MN 55144 USA.
EM acollinsworth@solventum.com
OI Collinsworth, Ashley/0000-0001-8039-7586
CR Aburn R., 2021, Wounds UK, V17, P51
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   Matthews MR, 2018, CUREUS J MED SCIENCE, V10, DOI 10.7759/cureus.3632
   McElroy E. F., 2019, WOC Next
   McElroy EF, 2019, INT WOUND J, V16, P781, DOI 10.1111/iwj.13097
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   Obst MA, 2019, WOUNDS, V31, pE33
   Strohal Robert, 2013, J Wound Care, V22, P5, DOI 10.12968/jowc.2013.22.Sup1.S1
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
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NR 32
TC 3
Z9 3
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL
PY 2025
VL 33
IS 4
AR e70059
DI 10.1111/wrr.70059
PG 15
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 6SI3P
UT WOS:001560849400002
PM 40583835
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU McNulty, AK
   Wilkes, RP
   Marchand, B
   Ingram, S
   Mann, S
   Sieracki, J
AF McNulty, Amy K.
   Wilkes, Robert P.
   Marchand, Brenda
   Ingram, Shannon
   Mann, Samantha
   Sieracki, James
TI Finite element and preclinical analysis of tissue response to negative
   pressure wound therapy with a felted foam containing 10 mm through holes
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Article
DE vacuum assisted closure (VAC); debridement; finite element analysis;
   negative pressure wound therapy with instillation; strain; friction;
   non-viable tissue
ID BED PREPARATION; INSTILLATION; MANAGEMENT
AB Introduction Not all wound patients are candidates for surgical debridement. A felted, reticulated open cell foam with an array of 10 mm holes (VFCC) for use with instillation therapy has been used to eliminate non-viable tissue from patient wound beds. The mechanisms for this have not been fully elucidated. The current study elaborates the biomechanical stresses, strains and work imparted to tissue with VFCC versus commonly used reticulated open cell foam (ROCF) dressings.Methods Finite element analysis (FEA) measured strain and deformation occurring at the tissue interface with VFCC or ROCF. FEA results were compared to those in a preclinical, porcine sloughy wound model.Results The peak maximum principal strain imparted to tissue at -125 mmHg with VFCC was 27.8% versus 0.9% with ROCF. The frictional work around the holes in the VFCC was 0.179 mJ while negligible with ROCF.Discussion The FEA model predicted high strains at the sides of the macrodomes of tissue pulled into the through holes and was consistent with slough removal in the preclinical study. Frictional work around the 10mmholes in the VFCC may pin the tissue leading to higher strain energy densities as tissue is pulled into the holes allowing for fracturing and removal of devitalized tissue.
C1 [McNulty, Amy K.; Wilkes, Robert P.; Marchand, Brenda; Ingram, Shannon; Mann, Samantha; Sieracki, James] Solventum, St Paul, MN 55144 USA.
RP McNulty, AK (通讯作者)，Solventum, St Paul, MN 55144 USA.
EM akmcnulty@solventum.com
FX The author(s) declare that no financial support was received for the
   research and/or publication of this article.
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NR 39
TC 1
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD AUG 21
PY 2025
VL 13
AR 1568540
DI 10.3389/fbioe.2025.1568540
PG 11
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 6VE8G
UT WOS:001562800300001
PM 40918443
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ramser, M
   Nennstiel, S
   Mueller, M
   Schlag, C
   Turina, M
AF Ramser, Michaela
   Nennstiel, Simon
   Mueller, Matteo
   Schlag, Christoph
   Turina, Matthias
TI Vacuum-assisted self-expanding stents in colorectal surgery: early
   experiences with a novel tool
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Anastomosis; Anastomotic leak; VAC; Stent; Prophylactic; Therapeutic;
   Colorectal cancer; Colon resection
ID LOW ANTERIOR RESECTION; ANASTOMOTIC LEAKAGE; MANAGEMENT; CANCER
AB BackgroundAnastomotic leakage (AL) remains a dreaded complication following colorectal resections. The routine use of diverting loop ileostomies (DLI), is associated with significant morbidity, triggering interest in alternative strategies. The VACStent Colon (VSC), a novel endoscopic treatment, combines vacuum-assisted closure with a self-expanding stent, providing luminal patency. Here we report our 1-year experience with the VSC.MethodsRetrospective analysis of patients treated with VSC at our department from 02/2024 to 03/2025 either therapeutically for AL or prophylactically in high-risk anastomoses. Outcomes, including continuous luminal patency by VSC, AL healing, complications, and need for DLI, were assessed with follow-up until endoscopic healing (EH) of AL.ResultsThirteen patients received a total of 47 VSC. Continuous luminal patency was achieved in 89.4%. Overall, 10 patients were treated with therapeutic intent (43 VSC). Nine patients achieved EH under VSC therapy (6 with DLI close, 2 awaiting DLI, one managed without DLI). One patient did not achieve EH. Three patients underwent prophylactic VSC therapy following high-risk anastomoses without a DLI. Notably, no AL occurred in this group. The most commonly observed complication was pain, particularly in distally placed VSC. Outpatient VSC therapy was successfully implemented in select cases.ConclusionVSC shows promising results as therapeutic tool for treating colorectal AL and as prophylactic measure in high-risk anastomoses. It offers the benefits of vacuum therapy combined with mechanical stenting providing luminal patency, potentially reducing the need for DLI.
C1 [Ramser, Michaela; Mueller, Matteo; Turina, Matthias] Univ Hosp Zurich, Dept Visceral and Transplant Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
   [Nennstiel, Simon; Schlag, Christoph] Univ Hosp Zurich, Dept Gastroenterol & Hepatol, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP Turina, M (通讯作者)，Univ Hosp Zurich, Dept Visceral and Transplant Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM matthias.turina@usz.ch
RI Schlag, Christoph/KXR-8170-2024
FU University of Zurich
FX Open access funding provided by University of Zurich. The authors
   received no funding for this research.
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NR 23
TC 1
Z9 1
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD NOV
PY 2025
VL 39
IS 11
BP 7356
EP 7365
DI 10.1007/s00464-025-12116-2
EA AUG 2025
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9TH6G
UT WOS:001563171600001
PM 40877630
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Zhang, JH
   Xie, ZJ
   Zhao, XB
   Su, W
AF Zhang, Jianhua
   Xie, Zhenjun
   Zhao, Xiaobing
   Su, Wei
TI Tube posterior tibial artery flow-through free flap for salvaging upper
   limbs with contaminated soft tissue defects and arterial injuries
SO JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
LA English
DT Article
DE Flow-through flap; posterior tibial artery; severely contaminated;
   vacuum sealing drainage (VSD)
ID TEMPORARY ECTOPIC IMPLANTATION; UPPER EXTREMITY; RECONSTRUCTION;
   COMPLICATIONS; FRACTURES; THERAPY; TRAUMA
AB The tube posterior tibial artery flow-through free flap technique is proposed for salvaging upper limbs with severely contaminated or infected soft tissue defects and major arterial injuries. Between January 2016 and February 2024, six patients were treated using this method. This is a two-stage approach involving initial restoration of blood supply via a tube posterior tibial artery flow-through free flap, followed by delayed soft tissue coverage utilizing the unfolded tube flap after a series of wound debridements and vacuum sealing drainage treatments. All upper limbs and flaps completely survived. At the 2-year follow-up, the grip and pinch strength of the injured hands reached 37% (range 29-72%)and 31% (range 12-42%) of the contralateral sides, respectively. The mean Disabilities of the Arm, Shoulder, and Hand score was 60 (range 53-67). This study demonstrates the feasibility and efficacy of the tube posterior tibial artery flow-through free flap technique in complex upper limb salvage cases.Level of evidence: IV
C1 [Zhang, Jianhua; Su, Wei] Guangxi Med Univ, Affiliated Hosp 1, Dept Orthopaed Trauma & Hand Surg, Nanning 530021, Guangxi Zhuang, Peoples R China.
   [Zhang, Jianhua; Xie, Zhenjun; Zhao, Xiaobing] Henan Prov Peoples Hosp, Dept Hand & Foot Microsurg, Zhengzhou, Peoples R China.
C3 Guangxi Medical University; Zhengzhou University
RP Su, W (通讯作者)，Guangxi Med Univ, Affiliated Hosp 1, Dept Orthopaed Trauma & Hand Surg, Nanning 530021, Guangxi Zhuang, Peoples R China.
EM gxsuwei@163.com
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1753-1934
EI 2043-6289
J9 J HAND SURG-EUR VOL
JI J. Hand Surg.-Eur. Vol.
PD FEB
PY 2026
VL 51
IS 2
BP 209
EP 215
DI 10.1177/17531934251367567
EA AUG 2025
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA DB1TI
UT WOS:001563529100001
PM 40884839
DA 2026-07-24
ER
PT J
AU Cristino, MAB
   Nakano, LCU
   Vasconcelos, V
   Correia, RM
   Flumignan, RLG
AF Cristino, Mateus A. B.
   Nakano, Luis C. U.
   Vasconcelos, Vladimir
   Correia, Rebeca M.
   Flumignan, Ronald L. G.
TI Prevention of infection in aortic or aortoiliac peripheral arterial
   reconstruction
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Anti-Bacterial Agents [therapeutic use]; Aorta [surgery]; Aortic
   Aneurysm [surgery]; Bias; Iliac Artery [surgery]; Peripheral Arterial
   Disease [surgery]; Randomized Controlled Trials as Topic; Surgical Wound
   Infection [prevention & control]; Vascular Surgical Procedures [adverse
   effects]; Aged; Humans
ID PERIOPERATIVE ANTIBIOTIC-PROPHYLAXIS; NEGATIVE-PRESSURE THERAPY;
   RANDOMIZED CLINICAL-TRIAL; SURGICAL SITE INFECTIONS; VASCULAR-SURGERY;
   DOUBLE-BLIND; ANTIMICROBIAL PROPHYLAXIS; WOUND-INFECTION;
   COST-EFFECTIVENESS; HEALTH-CARE
AB Background
   Peripheral arterial disease (PAD) results from the narrowing of arteries. Aortic aneurysms abnormal dilatations in artery walls are a related concern. For severe cases, arterial reconstruction surgery is the treatment option. Surgical site infections (SSIs) are a feared and common complication of vascular surgery. These infections have a significant global healthcare impact. Evaluating the effectiveness of preventive measures is essential.
   Objectives
   To assess the effects of pharmacological and non-pharmacological interventions, including antimicrobial therapy, antisepsis, and wound management, for the prevention of infection in people undergoing any open or hybrid aortic or aortoiliac peripheral arterial reconstruction.
   Search methods
   The Cochrane Vascular Information Specialist searched the Cochrane Vascular Specialised Register, CENTRAL, MEDLINE, Embase, and CINAHL databases, and the World Health Organization International Clinical Trials Registry Platform, LILACS, and ClinicalTrials.gov up to 11 November 2024.
   Selection criteria
   We included all randomised controlled trials (RCTs) with a parallel (e.g. cluster or individual) or split-body design, and quasi-RCTs, which assessed any intervention to reduce or prevent infection following aortic or aortoiliac procedures for the treatment of aneurysm or PAD. There were no limitations regarding age and sex.
   Data collection and analysis
   We used standard Cochrane methodological procedures. Two review authors independently extracted the data and assessed the risk of bias of the trials. A third review author resolved disagreements when necessary. We assessed the evidence certainty for key outcomes using GRADE.
   Main results
   We included 21 RCTs with 4952 participants. Fifteen studies were assessed as having a high risk of bias in at least one domain, and 19 studies had an unclear risk of bias in at least one domain. We analysed 10 different comparisons for eight different outcomes. The comparisons were antibiotic versus placebo or no treatment; short-duration antibiotics (= 24 hours) versus long-duration antibiotics (> 24 hours); different types of systemic antibiotics (one versus another); antibiotic-bonded implant versus standard implant; Dacron graft versus stretch polytetrafluoroethylene graft; prophylactic closed suction drainage versus undrained wound; individualised goal-directed therapy (IGDT) versus fluid therapy based on losses, standard haemodynamic parameters and arterial blood gas values (standard care); comprehensive geriatric assessment versus standard preoperative care; percutaneous versus open-access technique; and negative pressure wound therapy (NPWT) versus standard dressing. The primary outcomes were graft infection rate and SSI rate. The secondary outcomes included all-cause mortality, arterial reconstruction failure rate, re-intervention rate, amputation rate, pain resulting from the intervention, and adverse events resulting from the interventions to prevent infection. We did not assess all the outcomes across the different comparisons. The main findings are presented below.
   Antibiotic versus placebo or no treatment (five studies)
   Very low-certainty evidence from five included studies suggests that antibiotic prophylaxis reduces SSI (risk ratio (RR) 0.33, 95% confidence interval (CI) 0.15 to 0.71; 5 studies, 583 participants; number needed to treat for an additional beneficial outcome (NNT) 9). With very low- to low-certainty evidence, there was little or no difference between the groups in the other assessed outcomes (graft infection rate, all-cause mortality, re-intervention rate, and amputation rate). We did not quantitatively assess other outcomes in this comparison.
   Short duration antibiotics (<= 24 hours) versus long duration antibiotics (> 24 hours) (three studies)
   Very low-certainty evidence from three included studies suggests that there is little or no difference in graft infection rate (RR 2.74, 95% CI 0.11 to 65.59; 1 study, 88 participants) or SSI rate (RR 3.65, 95% CI 0.59 to 7.71; 1 study, 88 participants) between short- and long-duration antibiotic prophylaxis. We did not quantitatively assess other outcomes in this comparison.
   Different types of systemic antibiotics (one versus another) (seven studies)
   We grouped seven studies comparing one antibiotic to another into three subgroups that compared different classes of antibiotics amongst themselves. We found little or no difference between the groups analysed. Graft infection rate: beta-lactams versus cephalosporins (RR 0.36, 95% CI 0.02 to 8.71; 1 study, 88 participants; very low-certainty evidence); glycopeptides versus cephalosporins (RR 5.00, 95% CI 0.24 to 103.05; 1 study, 238 participants; low-certainty evidence); one cephalosporin versus another (RR not estimable, CI not estimable; 1 study; 69 participants; very low-certainty evidence); SSI rate: beta-lactams and cephalosporins (RR 0.27, 95% CI 0.03 to 2.53; 2 studies, 229 participants; very low-certainty evidence); glycopeptides versus cephalosporins (RR 2.17, 95% CI 0.65 to 7.23; 2 studies, 312 participants; very low-certainty evidence); and one cephalosporin versus another (RR 1.26, 95% CI 0.21 to 7.45; 3 studies, 625 participants; very low-certainty evidence). We could extract all-cause mortality data for the glycopeptide versus cephalosporin comparison; there was little or no difference between groups (RR 1.33, 95% CI 0.30 to 5.83; 1 study, 238 participants; low-certainty evidence). We did not quantitatively assess other outcomes in this comparison.
   Authors' conclusions
   Very low-certainty evidence suggests that the use of prophylactic antibiotics may prevent SSIs in aortic or aortoiliac peripheral arterial reconstruction. We found no superiority amongst specific antibiotics or differences in extended antibiotic use (over 24 hours) compared with shorter use (up to 24 hours), with low-certainty evidence. For other interventions, very low- to moderate-certainty evidence showed little or no difference across various outcomes. We advise interpreting these conclusions with caution due to the limited number of events in all groups and comparisons.
C1 [Cristino, Mateus A. B.; Nakano, Luis C. U.; Vasconcelos, Vladimir; Correia, Rebeca M.; Flumignan, Ronald L. G.] Univ Fed Sao Paulo, Div Vasc & Endovasc Surg, Dept Surg, Sao Paulo, Brazil.
   [Nakano, Luis C. U.; Vasconcelos, Vladimir; Flumignan, Ronald L. G.] Univ Fed Sao Paulo, Cochrane Brazil, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP)
RP Nakano, LCU (通讯作者)，Univ Fed Sao Paulo, Div Vasc & Endovasc Surg, Dept Surg, Sao Paulo, Brazil.
EM luis.nakano1@gmail.com
RI Vasconcelos, Vladimir/H-8028-2015; Flumignan, Ronald/P-6653-2016
FU Division of Vascular and Endovascular Surgery, Universidade Federal de
   Sao Paulo, Brazil Technical collaboration; Chief Scientist OFice,
   Scottish Government Health Directorates; Scottish Government; Chief
   Scientist Office
FX Internal sources Division of Vascular and Endovascular Surgery,
   Universidade Federal de Sao Paulo, Brazil Technical collaboration;
   non-financial support Source of funding, Other No financial support
   External sources Chief Scientist OFice, Scottish Government Health
   Directorates, The Scottish Government, UK The Cochrane Vascular
   editorial base is supported by the Chief Scientist Office.
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NR 169
TC 2
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2025
IS 4
AR CD015192
DI 10.1002/14651858.CD015192.pub2
PG 174
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7AW4J
UT WOS:001566656900002
PM 40260835
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Hu, XY
   Meng, HX
   Liang, JR
   An, H
   Zhou, JQ
   Gao, YL
   You, C
   Zhang, ZN
   Gong, XY
   Liu, Y
AF Hu, Xuyang
   Meng, Huixin
   Liang, Jiaru
   An, Hang
   Zhou, Jiaqi
   Gao, Yuling
   You, Chong
   Zhang, Zhenni
   Gong, Xiaoyang
   Liu, Yong
TI Comparison of the efficacy of 12 interventions in the treatment of
   diabetic foot ulcers: a network meta-analysis
SO PEERJ
LA English
DT Article
DE Diabetic foot ulcers; Network meta-analysis; Wound healing rate; Wound
   healing time; Percentage area reduction; Amputation rate
ID HYPERBARIC-OXYGEN THERAPY; PLATELET-RICH PLASMA;
   EPIDERMAL-GROWTH-FACTOR; PRESSURE WOUND THERAPY; VACUUM-ASSISTED
   CLOSURE; LOWER-EXTREMITY ULCERS; DOUBLE-BLIND; CONTROLLED-TRIAL;
   MONONUCLEAR-CELLS; SHOCKWAVE THERAPY
AB Objective. This study aimed to comprehensively compare the efficacy of 12 interventions for diabetic foot ulcer (DFU) using a network meta-analysis (NMA). Methods. The NMA was conducted by PRISMA guidelines, and the protocol was registered in PROSPERO (CRD42023461811). PubMed, Web of Science, Cochrane Library, and Embase databases were systematically searched from inception to September 2023. Randomized controlled trials (RCTs) enrolling patients with DFU were included if they compared epidermal growth factor (EGF), platelet-derived growth factor (PDGF), platelet-rich plasma (PRP), stem cells (SC), low-frequency ultrasound (LFU), negative pressure wound therapy (NPWT), low-level laser therapy (LLLT), electric stimulation (ES), extracorporeal shockwave therapy (ESWT), amniotic membrane therapy (AMT), hyperbaric oxygen therapy (HBOT), and topical oxygen therapy (TOT) against standard of care (SOC) or placebo. The primary endpoint assessed was the wound healing rate. Secondary endpoints comprised wound healing time, percentage area reduction (PAR), and amputation rate. The surface under the cumulative ranking curve (SUCRA) was calculated to rank the efficacy of interventions. Results. A total of 99 RCTs involving 7,356 patients were included. Among the 12 interventions analyzed, only LFU (OR = 2.20; 95% CI [0.99-4.91]) and ES (OR = 1.88; 95% CI [0.87-4.05]) did not demonstrate statistically significant improvements in ulcer healing rate compared with SOC. Based on SUCRA rankings, SC (SUCRA = 89.7%; OR = 5.71; 95% CI [2.64-12.34]) and AMT (SUCRA = 89.2%; OR = 5.11; 95% CI [3.12-8.37]) ranked highest in promoting ulcer healing, while LFU (29.4%) and SOC (10.4%) ranked lowest. Regarding wound healing time, AMT (MD = -26.91 days; 95% CI [-44.27 to -9.55]), PRP (MD = -21.65 days; 95% CI [-33.61 to -9.69]), and NPWT (MD = -16.79 days; 95% CI [-31.12 to -2.26]) significantly reduced healing durations compared to SOC. SUCRA rankings indicated that AMT (84.7%) and PRP (74.6%) ranked highest, while LFU (29.4%) and SOC (10.4%) remained lowest. Concerning PAR, LLLT (MD = 34.27; 95% CI [17.35-51.20]) and ESWT (MD = 27.50; 95% CI [11.00-44.00]) showed significant improvements over SOC, with LLLT (SUCRA = 93.9%) and ESWT (SUCRA = 84.0%) ranking highest, while SOC (21.0%) and TOT (18.3%) ranked lowest. For amputation rate, SC (OR = 0.12; 95% CI [0.03-0.55]) and HBOT (OR = 0.35; 95% CI [0.16-0.78]) significantly lowered the risk compared to SOC, with SUCRA rankings placing SC (79.9%) and PRP (73.2%) as most effective, while NPWT (26.4%) and SOC (9.9%) were least effective. Conclusions. SC and AMT emerged as highly effective, demonstrating superior efficacy in improving healing rate compared to PDGF, ES, and HBOT. AMT also showed significant effects in shortening ulcer healing time. LLLT exhibited considerable effectiveness in reducing ulcer areas, and SC therapy was associated with reduced amputation rate.
C1 [Hu, Xuyang; Zhou, Jiaqi; Gao, Yuling; Zhang, Zhenni; Gong, Xiaoyang; Liu, Yong] Dalian Med Univ, Dept Rehabil Med, Affiliated Hosp 1, Dalian, Peoples R China.
   [Hu, Xuyang; Meng, Huixin; Liang, Jiaru; An, Hang; You, Chong; Liu, Yong] Dalian Med Univ, Inst Coll Integrat Med, Dalian, Peoples R China.
C3 Dalian Medical University; Dalian Medical University
RP Gong, XY; Liu, Y (通讯作者)，Dalian Med Univ, Dept Rehabil Med, Affiliated Hosp 1, Dalian, Peoples R China.; Liu, Y (通讯作者)，Dalian Med Univ, Inst Coll Integrat Med, Dalian, Peoples R China.
EM rowlandgxy@163.com; fuwa52008@126.com
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NR 156
TC 5
Z9 6
U1 4
U2 6
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD AUG 11
PY 2025
VL 13
AR e19809
DI 10.7717/peerj.19809
PG 34
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 7EM6Z
UT WOS:001569115000001
PM 40821981
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Portou, MJ
   Collinsworth, AW
   Lookess, S
AF Portou, Mark J.
   Collinsworth, Ashley W.
   Lookess, Siobhan
TI Accelerating Patient Transitions From Hospital to Home in the United
   Kingdom With Single-Use Negative Pressure Wound Therapy: A Discharge
   Pathway
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE discharge pathway; wound healing; community; health services; health
   care costs; cost savings
ID VACUUM-ASSISTED CLOSURE; COSTS; CARE; RECOMMENDATIONS; MANAGEMENT;
   LENGTH; IMPACT
AB Background. Initially limited to inpatient use, negative pressure wound therapy (NPWT) is now frequently used in community settings. However, complexities in wound management step-down strategies in the United Kingdom, including regional variations in referral processes, lack of consensus on funding criteria, and limited availability of NPWT units, have led to extended hospital length of stay (LOS) for patients ready for discharge but still needing NPWT. Single-use NPWT (sNPWT) can serve as a bridge between hospital and community NPWT. Objective. To assess the feasibility, effectiveness, and potential cost savings of the implementation of a discharge pathway utilizing sNPWT. Methods. This case series included 5 patients with open lower limb wounds treated at a National Health Service facility using an sNPWT discharge pathway. Wounds were assessed before and after sNPWT use. Differences in average inpatient LOS and costs were calculated and compared with those for patients who remained hospitalized until community NPWT was available. Results. The sNPWT discharge pathway was well tolerated by patients and resulted in good clinical outcomes. Patients discharged on sNPWT had an average reduction in LOS of 20.2 days, resulting in a projected 12 pound 350 savings in hospital costs per patient. Conclusion. Preliminary findings indicate use of an sNPWT discharge pathway is feasible and may result in reduced LOS and associated costs while improving patient care. Additional studies are needed to understand the effect on wound management, patient outcomes, and overall care costs.
C1 [Portou, Mark J.] Royal Free London NHS Fdn Trust, London, England.
   [Collinsworth, Ashley W.; Lookess, Siobhan] Solventum, Maplewood, MN USA.
C3 University of London; University College London; Royal Free London NHS
   Foundation Trust
RP Collinsworth, AW (通讯作者)，12930 W Interstate 10, San Antonio, TX 78249 USA.
EM acollinsworth@solventum.com
CR Anchalia Manjulata, 2020, Wounds, V32, pE84
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Boti L, 2022, WOUNDS, V34, pE118, DOI 10.25270/wnds/22050
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NR 28
TC 0
Z9 0
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2025
VL 37
IS 8
BP 305
EP 313
DI 10.25270/wnds/24202
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 7HE1W
UT WOS:001570925400004
PM 40931370
DA 2026-07-24
ER
PT J
AU Roberson, DS
   McLeay, MT II
   Henning, G
   Morales-Martinez, G
   Thapa, P
   Khanna, A
   Frank, I
   Tollefson, MK
   Shah, P
   Karnes, RJ
   Boorjian, SA
   Sharma, V
AF Roberson, Daniel S.
   McLeay II, Matthew T.
   Henning, Grant
   Morales-Martinez, Gianni
   Thapa, Prabin
   Khanna, Abhinav
   Frank, Igor
   Tollefson, Matthew K.
   Shah, Paras
   Karnes, R. Jeffrey
   Boorjian, Stephen A.
   Sharma, Vidit
TI The impact of prophylactic incisional negative pressure wound therapy on
   surgical site infection following open radical cystectomy
SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
LA English
DT Article
DE Negative pressure wound therapy; Surgical wound infection; Abdominal
   wound closure; Cystectomy; Bladder cancer
ID PREVENTION; LAPAROTOMY; MORBIDITY; TRIAL
AB Purpose: Surgical site infection (SSI) following open radical cystectomy (ORC) is common and carries significant morbidity. Incisional negative pressure wound therapy (iNPWT) has not been rigorously studied in this population. Herein, we evaluate the association between prophylactic iNPWT and postoperative wound complications in ORC patients. Materials and methods: We queried our institutional, prospectively maintained cystectomy registry for patients who underwent ORC between 2000 and 2023, and stratified patients by receipt of prophylactic iNPWT. The primary outcome was SSI incidence within 90-days following surgery. Secondary outcomes included 90-day wound dehiscence, symptomatic seroma, and a composite endpoint of any of those 3 wound events. Multivariable logistic regression models adjusted for patient characteristics. Results: Among 2,375 patients who underwent ORC, 124(5.2%) received prophylactic iNPWT. Patients who received iNPWT had higher rates of SSI risk factors: median BMI (31 vs. 28, P < 0.01), diabetes (28% vs. 18%, P = 0.01), and ileal conduit diversion (86% vs. 71%, P < 0.01). On unadjusted analyses, SSI incidence was 6.5% and 10.4% for the iNPWT and non-iNPWT cohorts, respectively. After adjusting for baseline characteristics, prophylactic iNPWT was associated with a significantly lower odds of SSI (OR 0.47, 95%CI 0.22-0.99, P = 0.048). No significant associations were observed between iNPWT utilization and secondary outcomes. Conclusions: Prophylactic iNPWT therapy is associated with a reduced risk of SSI following ORC. While prospective and randomized corroboration is warranted, these data support the incorporation of this low-cost intervention into postoperative pathways for high-risk ORC patients. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Roberson, Daniel S.; McLeay II, Matthew T.; Henning, Grant; Morales-Martinez, Gianni; Khanna, Abhinav; Frank, Igor; Tollefson, Matthew K.; Shah, Paras; Karnes, R. Jeffrey; Boorjian, Stephen A.; Sharma, Vidit] Mayo Clin, Dept Urol, Rochester, MN 55905 USA.
   [Thapa, Prabin] Mayo Clin, Dept Hlth Serv Res, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Roberson, DS (通讯作者)，Mayo Clin, Dept Urol, Rochester, MN 55905 USA.
EM Roberson.daniel@mayo.edu
RI ; Rader, Daniel/AFQ-9696-2022
OI Henning, Grant/0000-0003-4582-6685; 
CR Gul ZG, 2021, TRANSL ANDROL UROL, V10, P2209, DOI 10.21037/tau.2019.11.32
   Javed AA, 2019, ANN SURG, V269, P1034, DOI 10.1097/SLA.0000000000003056
   Joice GA, 2020, EUR UROL FOCUS, V6, P698, DOI 10.1016/j.euf.2019.09.016
   Kuper TM, 2020, ANN SURG, V271, P67, DOI 10.1097/SLA.0000000000003435
   Li PY, 2017, SCAND J SURG, V106, P189, DOI 10.1177/1457496916668681
   Mangram AJ, 1999, AM J INFECT CONTROL, V27, P97, DOI 10.1016/S0196-6553(99)70088-X
   Murphy PB, 2019, ANN SURG, V270, P38, DOI 10.1097/SLA.0000000000003111
   Norman G, 2020, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD009261.pub6, 10.1002/14651858.CD009261.pub5]
   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
   Parker WP, 2016, UROL ONCOL-SEMIN ORI, V34, DOI 10.1016/j.urolonc.2016.07.001
   Putri IL, 2022, INT WOUND J, V19, P1578, DOI 10.1111/iwj.13756
   Sahebally SM, 2018, JAMA SURG, V153, DOI 10.1001/jamasurg.2018.3467
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   Shen P, 2017, J AM COLL SURGEONS, V224, P726, DOI 10.1016/j.jamcollsurg.2016.12.028
   Soares KC, 2015, AM J SURG, V209, P324, DOI 10.1016/j.amjsurg.2014.06.022
NR 17
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1078-1439
EI 1873-2496
J9 UROL ONCOL-SEMIN ORI
JI Urol. Oncol.-Semin. Orig. Investig.
PD OCT
PY 2025
VL 43
IS 10
BP 586
EP 593
DI 10.1016/j.urolonc.2025.07.010
EA JAN 2025
PG 8
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Urology & Nephrology
GA 7JF6T
UT WOS:001572321900008
PM 40796397
DA 2026-07-24
ER
PT J
AU Oliveira, IS
   Finelli, CA
   Ribeiro, TC
   Cunha, CC
   Durigon, TS
   Vargas, RP
   Tuma, RB
   Klautau, GB
   Reis, FB
   Salles, MJ
AF Oliveira, Icaro Santos
   Finelli, Carlos Augusto
   Ribeiro, Taiana Cunha
   Cunha, Carolina Coelho
   Durigon, Thomas Stravinskas
   Vargas, Rodrigo Peixoto
   Tuma, Rafael Brull
   Klautau, Giselle Burlamaqui
   dos Reis, Fernando Baldy
   Salles, Mauro Jose
TI The impact of a multidisciplinary team on the management of
   fracture-related infections: A surveillance study in Brazil
SO BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Fracture-related infection; Multidisciplinary teams; Biofilm;
   Osteomyelitis; Antibiotic stewardship; Prevention; Diagnosis
ID GUIDE
AB Background: Fracture-Related Infection (FRI) is an increasing and challenging complication following orthopedic trauma surgery. Preventive and microbial diagnostic measures vary significantly particularly in low- and middleincome countries. The objectives of this national questionnaire were to investigate clinical practices towards preventive and diagnostic strategies adopted by Brazilian orthopedic trauma centers and to assess the impact of Multidisciplinary Teams (MDT) on the management of FRI. Methods: A 34-item electronic questionnaire was developed via REDCap (R) and distributed to all trauma surgeons registered of the Brazilian Society of Orthopedics and Traumatology (SBOT). Results: With a response rate of 24 %, the survey was fully responded by 140 trauma surgeons, 63.6 % of them working in southeast region centers. Collaborative work with MDT focused on musculoskeletal infections was reported by only 41.0 %. Cephalosporins were universally prescribed as Perioperative Antibiotic Prophylaxis (PAP), while association with an aminoglycoside increased (35.0 %) for severe open fracture. One-day duration of PAP for closed fracture was prescribed in 68.1 %, while it often exceeded current recommendations. Diagnostic practices for FRI patients were primarily based on clinical signs and standard radiological and laboratory tests, with limited use of microbiological techniques. Trauma services working collaboratively with MDT significantly improved FRI management, including, use of sonication fluid for diagnosis (46.6 % vs. 26.8 %; p = 0.02), body weight-adjusted antibiotic dosing for PAP (50.0 % vs. 24.4 %; p = 0.02), appropriate duration of PAP according to the severity of soft-tissue damage (80.7 % vs. 59.3 %; p = 0.01), infection risk stratification in elderly patients with fractures (45.6 % vs. 21.0 %; p < 0.001), use of negative-pressure wound therapy (87.9 % vs. 54.9 %; p < 0.001) and regular collaboration with orthoplastic surgeon (44.8 % vs. 17.5 %; p = 0.01). Conclusions: This national survey revealed marked heterogeneity in FRI management across Brazilian trauma services. Ongoing MDT collaboration improved clinical practice, especially diagnostic work-up and antimicrobial stewardship.
C1 [Oliveira, Icaro Santos; Finelli, Carlos Augusto; Cunha, Carolina Coelho; Durigon, Thomas Stravinskas; dos Reis, Fernando Baldy; Salles, Mauro Jose] Univ Fed Sao Paulo UNIFESP, Dept Ortopedia & Traumatol, Escola Paulista Med EPM, Grp Infeccao Musculoesquelet Ortoinfecto, Sao Paulo, SP, Brazil.
   [Oliveira, Icaro Santos; Ribeiro, Taiana Cunha; Vargas, Rodrigo Peixoto; Klautau, Giselle Burlamaqui; Salles, Mauro Jose] Santa Casa Sao Paulo, Fac Ciencias Med, Disciplina Infectol, Sao Paulo, SP, Brazil.
   [Finelli, Carlos Augusto; Cunha, Carolina Coelho; Durigon, Thomas Stravinskas; Tuma, Rafael Brull; Salles, Mauro Jose] Univ Fed Sao Paulo UNIFESP, Dept Med, Div Doencas Infecciosas, Lab Especial Microbiol Clin LEMC,Escola Paulista M, Sao Paulo, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP)
RP Salles, MJ (通讯作者)，Univ Fed Sao Paulo UNIFESP, Dept Ortopedia & Traumatol, Escola Paulista Med EPM, Grp Infeccao Musculoesquelet Ortoinfecto, Sao Paulo, SP, Brazil.; Salles, MJ (通讯作者)，Santa Casa Sao Paulo, Fac Ciencias Med, Disciplina Infectol, Sao Paulo, SP, Brazil.; Salles, MJ (通讯作者)，Univ Fed Sao Paulo UNIFESP, Dept Med, Div Doencas Infecciosas, Lab Especial Microbiol Clin LEMC,Escola Paulista M, Sao Paulo, SP, Brazil.
EM mauro.salles@unifesp.br
RI ; Salles, Mauro Jose/K-4760-2012; Baldy dos Reis, Fernando/HPD-0369-2023
OI Finelli, Carlos Augusto/0000-0002-9602-0529; Brull Tuma,
   Rafael/0009-0006-3091-8594; Durigon, Thomas/0000-0002-4951-0963;
   Oliveira, Ícaro/0009-0007-8130-7926; Salles, Mauro
   Jose/0000-0002-5443-6024; Cunha, Carolina/0000-0002-7140-3152; Ribeiro,
   Taiana/0000-0002-4163-2288; VARGAS, ROIGO/0000-0001-9764-319X; Baldy dos
   Reis, Fernando/0000-0003-2431-2634
FU CNPq [402/2021-4, 516/2021-4]
FX This research is part of a larger project entitled "Epidemiological and
   microbiological analysis of infections associated with orthopedic
   fractures in Brazil: An observational, multicenter cohort study", funded
   by CNPq under process number 402,516/2021-4. However, in this part, no
   specific funding was received from public, commercial, or non-profit
   sector funding agencies.
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NR 48
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER BRAZIL
PI RIO DE JANEIRO
PA R SETE SETEMBRO, 111-16, RIO DE JANEIRO, RJ 20050-006, BRAZIL
SN 1413-8670
EI 1678-4391
J9 BRAZ J INFECT DIS
JI Braz. J. Infect. Dis.
PD NOV-DEC
PY 2025
VL 29
IS 6
AR 104576
DI 10.1016/j.bjid.2025.104576
EA SEP 2025
PG 8
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 7KB8F
UT WOS:001572899700001
PM 40939442
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Foley, MP
   Fahey, C
   Byrne, AM
   Lowery, A
   Walsh, SR
AF Foley, Megan Power
   Fahey, Ciara
   Byrne, Anne-Marie
   Lowery, Aoife
   Walsh, Stewart R.
TI Systematic Review and Meta-analysis of Prophylactic Negative Pressure
   Wound Therapy Devices for Major Lower Extremity Amputations
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE Major lower extremity amputation; Negative pressure wound therapy;
   Surgical complications; Surgical site infection
ID SURGICAL SITE INFECTION; LOWER-LIMB AMPUTATION; RISK-FACTORS;
   COMPLICATIONS; PREVENTION; MORTALITY; TRENDS; IMPACT; COSTS
AB Objective: Major lower extremity amputations are commonly performed for limb threatening ischaemia and uncontrollable infection. The dysvascular and diabetic cohort have multiple risk factors for post-operative wound complications. Prophylactic incisional negative pressure wound therapy (NPWT) has been associated with significantly lower rates of surgical site infection (SSI). The aim of this updated systematic review was to examine the impact of NPWT on outcomes after major amputations. Data Sources: PubMed, Scopus, Embase, conference abstracts, and trial registries were searched. Review Methods: Studies of all methodologies comparing NPWT applied to closed incisions with dry dressings after major amputations were eligible. The meta-analyses compared the relative risk (RR) of overall wound complications and SSIs between NPWT and standard care. Risk of bias was assessed using the Methodological Index for Non-Randomised Studies (MINORS) criteria and Cochrane Risk of Bias 2 tool. Outcome certainty was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria. Results: Nine studies were identified, including three randomised controlled trials (RCTs) and six cohort studies. Overall study quality was moderate to poor, with very low outcome certainty on GRADE analyses. Seven hundred and forty-nine patients were included, with 336 receiving NPWT and 413 standard care. The pooled rate of wound complications was 16.0% (95% confidence interval [CI] 9.5-24.0%) for NPWT and 44.6% (95% CI 29.0-60.9%) for standard care. Prophylactic NPWT was associated with a statistically significantly lower composite complication rate (RR 0.42, 95% CI 0.29-0.60; p<.001; I-2= 0%) and SSI rate (RR 0.51, 95% CI 0.31-0.83; p=.007; I-2= 0%) compared with standard care. Conclusion: Although the quality of the included studies was variable, prophylactic NPWT may reduce wound complications after major amputation. Further adequately powered RCTs are needed to clarify the benefits and cost effectiveness of NPWT in this cohort, including whether it should be used routinely or selectively.
C1 [Foley, Megan Power; Lowery, Aoife; Walsh, Stewart R.] Univ Galway, Dept Surg, Galway, Ireland.
   [Foley, Megan Power; Walsh, Stewart R.] Univ Hosp Galway, Dept Vasc Surg, Newcastle Rd, Galway H91 YR71, Ireland.
   [Fahey, Ciara; Byrne, Anne-Marie; Walsh, Stewart R.] Royal Coll Surgeons Ireland, Natl Surg Res Support Ctr, Dublin, Ireland.
   [Lowery, Aoife] Hlth Res Board Clin Res Facil, Galway, Ireland.
   [Walsh, Stewart R.] Univ Galway, Lambe Inst Translat Res, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Royal College of Surgeons in
   Ireland - RCSI; Ollscoil na Gaillimhe-University of Galway
RP Foley, MP (通讯作者)，Univ Hosp Galway, Dept Vasc Surg, Newcastle Rd, Galway H91 YR71, Ireland.
EM meganpfoley@rcsi.com
RI Walsh, Stewart/AFZ-2791-2022; Power Foley, Megan/JXX-0685-2024
OI Walsh, Stewart/0000-0002-1006-9541; Fahey, Ciara/0009-0006-6620-0111;
   LOWERY, AOIFE/0000-0002-8062-6235; 
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NR 49
TC 4
Z9 4
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD SEP
PY 2025
VL 70
IS 3
BP 346
EP 356
DI 10.1016/j.ejvs.2025.04.026
EA SEP 2025
PG 11
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 7LS3F
UT WOS:001574007000001
PM 40228785
DA 2026-07-24
ER
PT J
AU Litchinko, A
   Ris, F
   Noiret, B
   Adamina, M
   Denost, Q
AF Litchinko, A.
   Ris, F.
   Noiret, B.
   Adamina, M.
   Denost, Q.
TI Evaluating negative-pressure wound therapy after abdominoperineal
   resection: a systematic review of efficacy and technical variability
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Review
DE Abdominoperineal resection; Prophylactic negative-pressure wound
   therapy; Perineal wound complications; Surgical site infection
ID LOW RECTAL-CANCER; INTERSPHINCTERIC RESECTION; EXCISION; COMPLICATIONS;
   INFECTIONS; MANAGEMENT; CLOSURE; IMPACT; RISK
AB BackgroundPerineal wound complications after abdominoperineal resection (APR) for anal or low rectal cancer remain a significant clinical concern, frequently leading to surgical site infections (SSIs), wound dehiscence, and delayed healing. These complications contribute to increased patient morbidity, prolonged hospitalization, and higher healthcare costs. Prophylactic negative pressure wound therapy (pNPWT) has been proposed to improve wound outcomes in this context, but evidence regarding its effectiveness remains inconclusive.ObjectiveThis systematic review evaluates the clinical outcomes and technical application of pNPWT in closed perineal wounds following APR, with a focus on its potential impact on SSIs, wound dehiscence, and healing time.MethodsA systematic literature search was conducted in MEDLINE, Embase, and the Cochrane Library in accordance with PRISMA guidelines. Eligible studies included randomized controlled trials and observational studies assessing pNPWT after APR. Key outcomes of interest were SSI rates, wound dehiscence, healing time, and length of hospital stay. Due to clinical and methodological heterogeneity, a narrative synthesis was performed.ResultsIn total, eight studies met the inclusion criteria. The results were heterogeneous: while three studies reported reduced SSI rates with pNPWT compared with conventional wound management, two studies observed higher SSI rates in the pNPWT groups. Variability in device type (canister-based versus portable systems), negative pressure settings, application duration, and patient selection limited the comparability across studies. The risk of bias was moderate to high in several studies, and outcome reporting was inconsistent.ConclusionsCurrent evidence does not allow for definitive conclusions regarding the clinical benefit of pNPWT after APR. While some studies suggest potential advantages, particularly in terms of SSI reduction, results remain inconsistent and device-dependent. Further high-quality randomized trials are required to clarify the role of pNPWT and to define optimal application protocols in this challenging surgical context.
C1 [Litchinko, A.; Adamina, M.] Univers Hosp Fribourg, Div Digest Surg, HFR Fribourg Cantonal Hosp, Chemin Pensionnat 2-6, CH-1752 Fribourg, Switzerland.
   [Litchinko, A.; Ris, F.; Adamina, M.] HFR Fribourg Cantonal Hosp, Fac Sci, CH-1711 Fribourg, Switzerland.
   [Litchinko, A.] Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Noiret, B.; Denost, Q.] Bordeaux Colorectal Inst, 220 Rue Mandron, F-33300 Bordeaux, France.
C3 University of Geneva
RP Litchinko, A (通讯作者)，Univers Hosp Fribourg, Div Digest Surg, HFR Fribourg Cantonal Hosp, Chemin Pensionnat 2-6, CH-1752 Fribourg, Switzerland.; Litchinko, A (通讯作者)，HFR Fribourg Cantonal Hosp, Fac Sci, CH-1711 Fribourg, Switzerland.; Litchinko, A (通讯作者)，Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM alexis.litchinko@gmail.com
FU University of Fribourg
FX Open access funding provided by University of Fribourg. None.
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NR 36
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD SEP 23
PY 2025
VL 29
IS 1
AR 168
DI 10.1007/s10151-025-03212-5
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 7PY2G
UT WOS:001576875800001
PM 40987996
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Schewe, S
   Sagebiel, A
   Wakker, J
   Voss, N
   Al Shonikat, R
   Priemel, M
   Reiter, A
   Striefler, J
   Blessmann, M
   Hackert, T
   Dupree, A
AF Schewe, Simone
   Sagebiel, Adrian
   Wakker, Jonas
   Voss, Nina
   Al Shonikat, Ruba
   Priemel, Matthias
   Reiter, Alonja
   Striefler, Jana
   Blessmann, Marco
   Hackert, Thilo
   Dupree, Anna
TI Impact of vacuum assisted wound therapy on wound complications in STS
   surgery- A 3-year retrospective single-centre analysis
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Vacuum assisted wound closure; Soft tissue sarcoma; Sarcoma surgery;
   Wound complication; Postoperative complications; Secondary wound closure
ID SOFT-TISSUE SARCOMA; NEGATIVE-PRESSURE; RADIATION; CLOSURE
AB Purpose In sarcomas, surgery is an essential component of therapy. Depending on their location, sarcomas can reach a considerable size, which increases the risk of wound complications (WC) after resections. This often results in longer hospital stays and thus delays further oncological treatment. Therefore, reducing WCs is indispensable for improving treatment. The VAC (Vacuum-Assisted Closure) therapy has been shown to have a positive effect on wound healing, but there are limited studies for its use after sarcoma resections. The aim of this study was to analyze the outcomes of various wound closure techniques. This was intended to identify optimal wound care to prevent WCs and to determine risk factors for complications. Methods This study is a single-center study that included all patients who underwent surgery for sarcomas of the body surface and extremities. A retrospective data analysis was conducted for the years 2021-2023. The primary endpoint was the development of wound complications. Here, primary wound closure was compared with secondary closure after negative wound pressure therapy (NWPT). Secondary endpoints included the impact of drains, subtype, location, and comorbidities. Results A total of 211 patients were examined. The most common histological subtype was liposarcoma (32,88%), followed by undifferentiated sarcoma (19,18%). Wound complications occurred in 30,19% of all cases. The analysis showed that 40,4% of patients with primary wound closure developed a complication, while only 20% of patients with NWPT did. A significant risk factor for the development of a WC was a tumor diameter > 10 cm, which led to a 20,13% higher risk of infection compared to smaller tumors. 68.3% of wound complications occurred in the lower extremity. Additionally, neoadjuvant therapy, longer operation time and immunosuppression were detected as risk factors for a higher complication rate. Conclusions This study highlights the significantly increased risk of WCs in large sarcomas of the lower extremities. VAC therapy showed a significant improvement in wound closure especially in high-risk cases. Based on the results, the use of NWPT can be essential for wound management in sarcomas and improve convalescence and oncological treatment.
C1 [Schewe, Simone; Sagebiel, Adrian; Wakker, Jonas; Voss, Nina; Al Shonikat, Ruba; Hackert, Thilo; Dupree, Anna] Univ Med Ctr Hamburg Eppendorf, Dept Gen Visceral & Thorac Surg, Hamburg, Germany.
   [Priemel, Matthias; Reiter, Alonja] Univ Med Ctr Hamburg Eppendorf, Clin & Polyclin Trauma Surg & Orthoped, Hamburg, Germany.
   [Striefler, Jana] Univ Med Ctr Hamburg Eppendorf, Med Clin & Polyclin Oncol 2, Hematol, Dept Pulmonol, Hamburg, Germany.
   [Blessmann, Marco] Univ Med Ctr Hamburg Eppendorf, Dept Plast Reconstruct & Aesthet Surg, Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf
RP Schewe, S (通讯作者)，Univ Med Ctr Hamburg Eppendorf, Dept Gen Visceral & Thorac Surg, Hamburg, Germany.
EM s.schewe@uke.de
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 38
TC 2
Z9 4
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD SEP 25
PY 2025
VL 410
IS 1
AR 277
DI 10.1007/s00423-025-03865-8
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 7VU5E
UT WOS:001580845200002
PM 40996557
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Altaweel, A
   Meselhi, A
   Marzouk, H
   Shahin, HN
   Salim, M
   Mohamed, AM
   Khataybeh, IM
   Seif, AT
   Elbataa, A
   Metwalli, E
   Elgenidy, A
AF Altaweel, Ahmed
   Meselhi, Amr
   Marzouk, Hamza
   Shahin, Hatim N.
   Salim, Moustafa
   Mohamed, Alaa M.
   Khataybeh, Ismail M.
   Seif, Ahmed T.
   Elbataa, Ahmed
   Metwalli, Eslam
   Elgenidy, Anas
TI Effectiveness of Incisional Negative Pressure Wound Therapy in the
   Prevention of Post-Amputation Complications: Systematic Review and
   Meta-Analysis
SO ANNALS OF VASCULAR SURGERY
LA English
DT Review
ID SURGICAL-SITE INFECTIONS; NPWT
AB Background: Negative pressure wound therapy (NPWT) is an advanced therapy utilizing subatmospheric pressure at the wound site to generate a controlled environment that promotes blood flow and stabilizes the wound area. However, its effectiveness in diminishing surgical site complications remains unproven effectively. We aim to assess the impact of incisional NPWT (iNPWT) on the reduction of surgical wound complications, mortality rate, and improvement of healing rate following lower limb amputation. Methods: An extensive search was executed in several databases for relevant studies evaluating iNPWT following lower limb amputation. We used RevMan to calculate pooled risk ratio (RR) for dichotomous outcomes and mean difference (MD) for continuous outcomes with 95% confidence interval (95% CI). The outcomes of our analysis were the assessment of overall post-intervention wound complications, surgical site infection, need for revision surgery, seroma or hematoma formation, 30-day mortality, subsequent amputation, readmission, and the time taken for complete healing. Results: Ten studies, including atotal of 1,003 patients, were included in ouranalysis. The findings indicate asignificant reduction in the riskof overall post-intervention wound complications (RR, 0.41; 95% CI 0.20, 0.84) and a shorter time to complete healing (MD,-1.76 weeks; 95% CI-2.66,-0.86 weeks) compared to the control group. No significant difference was found in wound infection, seroma or hematoma formation, readmission, and mortality rates between the iNPWT and the control groups. Conclusion: iNPWT significantly reduces overall post-intervention wound complications and shortens the time required for complete healing.
C1 [Altaweel, Ahmed] Alexandria Univ, Fac Med, Alexandria, Egypt.
   [Meselhi, Amr] Bedfordshire Hosp NHS Fdn Trust, Bedford Hosp, 14 Meridian House,Kingsway Link, Bedford MK42 0JY, England.
   [Marzouk, Hamza] Jordan Univ Sci & Technol, Irbid, Jordan.
   [Shahin, Hatim N.] South Valley Univ, Fac Med, Qina, Egypt.
   [Salim, Moustafa; Mohamed, Alaa M.] Mansoura Univ, Fac Med, Mansoura, Egypt.
   [Khataybeh, Ismail M.] Prince Rashid Mil Hosp, Irbid, Jordan.
   [Seif, Ahmed T.; Elbataa, Ahmed] Al Azhar Univ, Fac Med, Cairo, Egypt.
   [Metwalli, Eslam] Worcestershire Acute Hosp NHS Trust, Redditch, Worcs, England.
   [Elgenidy, Anas] Cairo Univ, Fac Med, Cairo, Egypt.
   [Elgenidy, Anas] Karl Jaspers Klin, Zwishchenahn, Germany.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; Jordan University
   of Science & Technology; Egyptian Knowledge Bank (EKB); Qena University;
   Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Al Azhar University; Egyptian Knowledge Bank (EKB); Cairo
   University
RP Meselhi, A (通讯作者)，Bedfordshire Hosp NHS Fdn Trust, Bedford Hosp, 14 Meridian House,Kingsway Link, Bedford MK42 0JY, England.
EM amralla41@gmail.com
RI Elgenidy, Anas/AAV-1880-2021
OI Altaweel, Ahmed/0009-0009-7281-5624
CR Al-Saadi N, 2024, INT WOUND J, V21, DOI [10.1111/iwj.14946, 10.1111/iwj.14946]
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   cochrane, RoB 2: A revised Cochrane risk-of-bias tool for randomized trials | Cochrane Bias
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   The EndNote team, 2023, EndNote 20
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NR 20
TC 1
Z9 2
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD DEC
PY 2025
VL 121
BP 616
EP 632
DI 10.1016/j.avsg.2025.08.027
EA SEP 2025
PG 17
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 7YZ3Y
UT WOS:001583006300004
PM 40912637
DA 2026-07-24
ER
PT J
AU Leggieri, F
   Ferriani, F
   Di Benedetto, E
   Miani, E
   Festa, E
   Balato, G
   Rossi, SMP
   Benazzo, F
   Baldini, A
AF Leggieri, Filippo
   Ferriani, Francesco
   Di Benedetto, Enrico
   Miani, Enrick
   Festa, Enrico
   Balato, Giovanni
   Rossi, Stefano M. P.
   Benazzo, Francesco
   Baldini, Andrea
TI Time-dependent wound management protocol prevents periprosthetic joint
   infection in total knee arthroplasty with persistent drainage
SO KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
LA English
DT Article
DE DAIR (debridement, antibiotics, and implant retention); periprosthetic
   joint infection (PJI); persistent wound drainage; total knee
   arthroplasty (TKA)
ID SCORING METHOD ASEPSIS; PRIMARY TOTAL HIP; RISK-FACTORS; COMPLICATIONS
AB Purpose: This study aimed to evaluate the success rate of a standardised protocol for managing persistent wound drainage following total knee arthroplasty (TKA). Methods: A prospective observational study was conducted at four institutions between January and June 2022 across primary and revision TKAs. Sixty-two patients (mean age 71.5 +/- 9.3 years; 45.2% male) who experienced postoperative wound drainage after primary (58.1%) or revision (41.9%) TKA were enrolled. The protocol included staged interventions: anticoagulation adjustments and dressing changes during Days 1-3, incisional negative pressure wound therapy during Days 3-5, and wound debridement above the joint capsule if drainage persisted beyond Day 7. Outcomes were evaluated using the ASEPSIS score. The primary outcome was defined as complete wound healing without progression to debridement, antibiotics and implant retention (DAIR) procedure or periprosthetic joint infection (PJI). Results: The mean follow-up was 13.2 months (range, 11.7-15.1 months). The protocol achieved a 91.9% success rate in preventing progression to DAIR. The median number of visits required to achieve wound healing was 3.5 for the cohort. DAIR rate was 8.1% (n = 5), while PJI rate was 1.6% (n = 1). Primary TKA procedures demonstrated more efficient healing trajectories compared to revision cases, requiring fewer clinical visits (median 3 vs. 5, p < 0.001) and shorter hospital stays (mean 4.5 vs. 7.5 days, p = 0.017). Cox proportional hazards model identified intervention type (revision vs. primary, hazard ratio [HR] 0.24, p < 0.001), advanced age (HR: 0.95 per year, p = 0.006), and male gender (HR: 0.45, p = 0.020) as significant independent predictors of increased time required to achieve wound healing. Conclusion: Our standardised wound management protocol achieved a high success rate in preventing progression to PJI following TKA. The time-dependent approach to intervention escalation provides clear clinical decision-making criteria and suggests that early identification and systematic management of wound complications are critical determinants of successful outcomes, particularly for primary TKA procedures.
C1 [Leggieri, Filippo] Univ Firenze, Dept Clin Orthopaed, Azienda Univ Osped Careggi, Florence, Italy.
   [Ferriani, Francesco; Baldini, Andrea] Ist Fiorentino Cura & Assistenza, Orthoped Unit, Florence, Italy.
   [Di Benedetto, Enrico; Miani, Enrick] Azienda Sanitaria Univ Friuli Cent, SOC Ortopedia & Traumatol, Tolmezzo, Italy.
   [Festa, Enrico; Balato, Giovanni] Univ Naples Federico II, Dept Publ Hlth, Orthoped Unit, Naples, Italy.
   [Rossi, Stefano M. P.] Univ Studi Link, Dept Life Sci Hlth & Hlth Profess, Rome, Italy.
   [Rossi, Stefano M. P.] Fdn Poliambulanza, Unita Chirurg Robot UOC Ortoped & Traumatol, Brescia, Italy.
   [Benazzo, Francesco] Fdn Poliambulanza, UOC Ortoped & Traumatol, Brescia, Italy.
   [Benazzo, Francesco] Ist Univ Studi Superiori, Pavia, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi;
   University of Naples Federico II
RP Leggieri, F (通讯作者)，Univ Florence, Dept Clin Orthoped, AOU Careggi CTO, Largo Palagi 1, I-50139 Florence, Italy.
EM filippoleggieri@icloud.com
RI ; Benazzo, Francesco/AAV-9990-2020; Rossi, Stefano Marco
   Paolo/KGL-1404-2024; Leggieri, Filippo/JRY-0923-2023; Balato,
   Giovanni/AAC-5951-2022
OI Festa, Enrico/0000-0002-9923-1129; Rossi, Stefano Marco
   Paolo/0000-0003-4395-8457; Leggieri, Filippo/0009-0007-1289-8849;
   baldini, andrea/0000-0002-6073-8491
FU Universita degli Studi di Firenze, as part of the Wiley - CRUI-CARE
   agreement
FX Open access publishing facilitated by Universita degli Studi di Firenze,
   as part of the Wiley - CRUI-CARE agreement. The study followed the
   STROBE guidelines for reporting observational studies.
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NR 32
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0942-2056
EI 1433-7347
J9 KNEE SURG SPORT TR A
JI Knee Surg. Sports Traumatol. Arthrosc.
PD MAY
PY 2026
VL 34
IS 5
BP 1740
EP 1749
DI 10.1002/ksa.70077
EA SEP 2025
PG 10
WC Orthopedics; Sport Sciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences; Surgery
GA HF0II
UT WOS:001583938100001
PM 41020425
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Takami, T
   Itatani, Y
   Yoshida, Y
   Hoshino, N
   Ohno, R
   Okamura, R
   Hida, K
   Obama, K
AF Takami, Takuya
   Itatani, Yoshiro
   Yoshida, Yu
   Hoshino, Nobuaki
   Ohno, Ryo
   Okamura, Ryosuke
   Hida, Koya
   Obama, Kazutaka
TI Protocol for a study to evaluate the safety and efficacy of prophylactic
   negative pressure wound therapy after abdominal perineal resection
   (VACPAC study)
SO PLOS ONE
LA English
DT Article
ID ABDOMINOPERINEAL RESECTION; RECTAL-CANCER; INCISION MANAGEMENT;
   EXCISION; CLOSURE; RECONSTRUCTION; RADIOTHERAPY; INFECTIONS; SYSTEM
AB Introduction Abdominal perineal resection (APR) is a surgical procedure for rectal cancer that frequently results in perineal wound surgical site infections (SSI), particularly in high-risk patients undergoing preoperative treatment. SSI after APR is associated with prolonged hospital stay, increased medical costs, and delayed initiation of adjuvant chemotherapy, potentially leading to poor prognosis. Although omentoplasty and myocutaneous flap reconstruction have been used to prevent SSI, they are not always feasible. Prophylactic negative pressure wound therapy (pNPWT) has been shown to reduce SSI in high-risk wounds; however, its efficacy in APR remains unclear. This study aims to evaluate the safety and efficacy of pNPWT in preventing perineal wound SSI after APR.Methods and materials This is a multi-institutional, single-arm trial investigating pNPWT after APR. The study includes patients undergoing APR for malignant rectal tumors who meet the high-risk criteria for SSI. The intervention involves applying the 3M (TM) Prevena (TM) Plus Customizable system immediately after perineal skin closure, maintaining pNPWT for up to 7 days. The primary endpoint is the incidence of perineal wound SSI within 30 days. Secondary endpoints include postoperative complications (Clavien-Dindo Grade III or higher), hospital stay, and completion proportion of pNPWT.Discussion This study seeks to provide clinical evidence of the efficacy of pNPWT in reducing perineal wound SSI after APR. Given its ease of application and minimal invasiveness, pNPWT may serve as an effective approach for SSI prevention. These findings may contribute to the establishment of a standardized preventive approach for perineal wound management after APR.
C1 [Takami, Takuya; Itatani, Yoshiro; Yoshida, Yu; Hoshino, Nobuaki; Ohno, Ryo; Okamura, Ryosuke; Hida, Koya; Obama, Kazutaka] Kyoto Univ, Grad Sch Med, Dept Surg, Kyoto, Japan.
C3 Kyoto University
RP Itatani, Y (通讯作者)，Kyoto Univ, Grad Sch Med, Dept Surg, Kyoto, Japan.
EM itatani@kuhp.kyoto-u.ac.jp
RI ; Hida, Koya/AFU-1462-2022; Itatani, Yoshiro/GXA-0613-2022; OBAMA,
   KAZUTAKA/AAW-8263-2021
OI Okamura, Ryosuke/0000-0001-7352-8621; Itatani,
   Yoshiro/0000-0001-7356-7065; 
FU Japan society of laparoscopic colorectal surgery
FX Japan society of laparoscopic colorectal surgery
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 19
TC 0
Z9 0
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 29
PY 2025
VL 20
IS 8
AR e0331361
DI 10.1371/journal.pone.0331361
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8DB6L
UT WOS:001585788200027
PM 40880392
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, JX
   Wu, CF
   Xu, C
AF Li, Jiaxin
   Wu, Caifeng
   Xu, Chao
TI Temporal Vascularized Fascial Flap Combined With Bilayer Artificial
   Dermis for Scalp Reconstruction With Calvarial Exposure: A
   Bioengineering Strategy Integrating Angiogenesis and Dermal Regeneration
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Artificial dermis; fascial flap; skull exposure; wound reconstruction
AB The reconstruction of traumatic scalp defects with skull exposure presents multifaceted challenges, including compromised vascular reconstruction, periosteal defects, and high aesthetic demands. This study reports the case of a 57-year-old female patient with a post-traumatic right temporal scalp defect and skull exposure after a traffic accident. A staged protocol involving negative pressure wound therapy, pedicled fascial flap transfer, and bilayer artificial dermis grafting achieved complete wound closure within 15 days. At the 8-month follow-up, the Vancouver Scar Scale score was 1, demonstrating optimal aesthetic and functional restoration. This approach synergizes the vascularization advantages of fascial flaps with the regenerative properties of artificial dermis, effectively addressing limitations of traditional methods-such as flap bulkiness and donor site morbidity-and offers a novel paradigm for skull exposure defect reconstruction.
C1 [Li, Jiaxin; Xu, Chao] Shandong Second Med Univ, Sch Clin Med, Weifang, Peoples R China.
   [Wu, Caifeng] Qingdao Univ, Affiliated Hosp, Dept Hand & Foot, Microsurg, Qingdao, Peoples R China.
   [Li, Jiaxin; Xu, Chao] Zibo Cent Hosp, Dept Plast Surg, Zibo, Peoples R China.
C3 Shandong Second Medical University; Qingdao University
RP Xu, C (通讯作者)，Zibo Cent Hosp, Zibo 250036, Shandong, Peoples R China.
EM leejiaxin01@foxmail.com; wucfsweet@163.com; chaoxu0021@126.com
CR Amirsadeghi A, 2020, BIOMATER SCI-UK, V8, P4073, DOI 10.1039/d0bm00266f
   Ehrenfeld M., 2023, Pedicled Flaps Oral and maxillofacial surgery: Surgical textbook and atlas, P641
   Hodea FV, 2025, LIFE-BASEL, V15, DOI 10.3390/life15010036
   Horoz U., 2024, J Craniofac Surg, V[Epub ahead of print].
   Horta R., 2025, J Craniofac Surg, V[Epub ahead of print].
   Innocenti A., 2021, Major scalp defect reconstruction with free flap: analysis of the results, V92
   Li YM, 2022, ACS APPL BIO MATER, V5, P20, DOI 10.1021/acsabm.1c00979
   Qiu XW, 2018, J PLAST SURG HAND SU, V52, P204, DOI 10.1080/2000656X.2017.1421547
   Tan JL, 2017, BURNS TRAUMA, V5, DOI 10.1186/s41038-017-0080-1
NR 9
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD OCT
PY 2025
VL 36
IS 7
BP e997
EP e999
DI 10.1097/SCS.0000000000011564
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8JJ5B
UT WOS:001590070700006
PM 40587760
DA 2026-07-24
ER
PT J
AU Alateeq, MF
   Park, SW
   Ahn, JY
   Lee, YS
AF Alateeq, Mohammed F.
   Park, Sang-Wook
   Ahn, Ji Yong
   Lee, Yoon Se
TI Endoscopic Vacuum-Assisted Closure for Radiation-Induced
   Laryngotracheoesophageal Fistula
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Negative suction; radiation therapy; radionecrosis; tracheoesophageal
   fistula; vacuum
AB Radionecrosis can occur in any irradiated area of the head and neck, and when it involves the laryngotracheal region, it may lead to a laryngoesophageal fistula, causing dysphagia, aspiration, and life-threatening bleeding. A 45-year-old male with renal cell carcinoma (RCC) was referred due to prolonged dysphagia, recurrent aspiration, and hemoptysis after radiation therapy for a metastatic cervical spine lesion. Laryngoscopy and CT scan revealed destruction of the posterior cricoid cartilage and the membranous trachea, with a fistula formed between the laryngotrachea and pharynx. Due to extensive necrosis, wide debridement with reconstruction was initially considered. However, as the patient was receiving palliative treatment for multiple metastatic diseases, endoluminal vacuum-assisted closure (EVAC) was applied instead. EVAC, combined with antibiotics and nutritional support, successfully closed the fistula, allowing the patient to resume a normal diet. This case demonstrates that EVAC is a feasible method for treating laryngotracheal fistula while preserving laryngeal function with minimal complications.
C1 [Alateeq, Mohammed F.] Univ Hail, Dept Otolaryngol, Hail, Saudi Arabia.
   [Alateeq, Mohammed F.; Park, Sang-Wook; Lee, Yoon Se] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea.
   [Ahn, Ji Yong] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea.
C3 University Ha'il; University of Ulsan; Asan Medical Center; University
   of Ulsan; Asan Medical Center
RP Lee, YS (通讯作者)，Asan Med Ctr, 88 Olymp Ro,43 Gil, Seoul 05505, South Korea.
EM waw1413@hotmail.com; willjeffsw@gmail.com; ji110@hanmail.net;
   manseilee@gmail.com
RI Ahn, Ji Yong/AGO-1695-2022; alateeq, mohammed/KIC-8064-2024
OI Ahn, Ji Yong/0000-0002-0030-3744; alateeq, mohammed/0000-0002-7162-641X
FU Asan Institute for Life Sciences [2022IP0085]; Elimination of Cancer
   Project Fund from Asan Cancer Institute of Asan Medical Center, Seoul,
   Korea
FX This study was also supported by a grant (2022IP0085) from the Asan
   Institute for Life Sciences and the Elimination of Cancer Project Fund
   from Asan Cancer Institute of Asan Medical Center, Seoul, Korea.
CR Abugroun Ashraf, 2017, World J Oncol, V8, P171, DOI [10.14740/wjon1063w, 10.14740/wjon1063w]
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NR 10
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD OCT
PY 2025
VL 36
IS 7
BP e945
EP e947
DI 10.1097/SCS.0000000000011653
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8JJ5B
UT WOS:001590070700010
PM 40608776
DA 2026-07-24
ER
PT J
AU Abdelhakim, M
   Ogawa, R
AF Abdelhakim, Mohamed
   Ogawa, Rei
TI Emerging Therapies in Chronic Wound Healing: Advances in Stem Cell
   Therapy, Growth Factor Modulation, Mechanical Strategies and Adjuvant
   Interventions
SO DERMATOLOGY AND THERAPY
LA English
DT Review
DE Chronic wounds; Wound healing; Regenerative medicine; Mesenchymal stem
   cells; Adipose-derived stem cells; Growth factor therapy;
   Platelet-derived products; Negative pressure wound therapy; Shock wave
   therapy; Mechanobiology and tissue regeneration
ID AUTOLOGOUS KERATINOCYTES; SKIN; PATHWAYS; EFFICACY; ULCERS; FLAP
AB Chronic wounds pose a persistent clinical and economic burden, often failing to respond to standard care as a result of impaired angiogenesis, prolonged inflammation, and dysfunctional cellular activity. Emerging strategies in regenerative medicine offer new hope, particularly those focusing on stem cell therapy, growth factor modulation, and mechanical support. This narrative emphasizes the clinical applicability. We performed targeted searches of PubMed/MEDLINE and Embase using terms related to regenerative cell therapy, growth factor modulation, mechanical/physical strategies, adjuvant therapies, and platelet-derived products (PRP/PRF). We prioritized randomized/controlled studies, high-quality observational cohorts, meta-analyses, and consensus guidelines relevant to chronic wound healing, and we critically appraised heterogeneity and limitations. In particular, the latest innovations in chronic wound management, mesenchymal stem cells (MSCs), and adipose-derived stem cells (ASCs) have shown promise in promoting angiogenesis and modulating immune responses. Concurrently, the targeted delivery of cytokines such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF) is being optimized through advanced biomaterials to enhance healing microenvironments. Mechanical interventions, including negative pressure wound therapy (NPWT) and shock wave therapy, further support tissue repair and revascularization. Together, these approaches reflect a shift from symptomatic wound care to personalized, regenerative strategies. This review synthesizes preclinical and clinical data, explores translational challenges, and outlines future directions that integrate biology, bioengineering, and digital tools for optimized wound healing.
C1 [Abdelhakim, Mohamed; Ogawa, Rei] Nippon Med Sch, Dept Plast Reconstruct & Aesthet Surg, 1-1-5 Sendagi Bunkyo Ku, Tokyo 1138603, Japan.
C3 Nippon Medical School
RP Ogawa, R (通讯作者)，Nippon Med Sch, Dept Plast Reconstruct & Aesthet Surg, 1-1-5 Sendagi Bunkyo Ku, Tokyo 1138603, Japan.
EM r.ogawa@nms.ac.jp
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NR 50
TC 7
Z9 9
U1 3
U2 11
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 2193-8210
EI 2190-9172
J9 DERMATOLOGY THER
JI Dermatol. Ther.
PD DEC
PY 2025
VL 15
IS 12
BP 3533
EP 3545
DI 10.1007/s13555-025-01564-2
EA OCT 2025
PG 13
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 9TK2N
UT WOS:001590904800001
PM 41075105
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jiang, MY
   Wang, XJ
   Wu, YJ
   Xiao, YR
   Xiao, Q
   Xiong, J
   Shang, WW
AF Jiang, Mengyao
   Wang, Xuejun
   Wu, Yujie
   Xiao, Yaru
   Xiao, Qi
   Xiong, Jie
   Shang, Weiwei
TI Low-value clinical practices in pressure injury management: a scoping
   review
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Review
DE Pressure injury; Low-value care; Value-based care; Scoping review;
   Nursing
ID CARE; PREVENTION; STRATEGIES; COST
AB Background Low-value care (LVC) is increasingly recognized as a contributor to inefficiency in healthcare. Pressure injury (PI) is a key nursing-sensitive quality indicator and involve numerous interventions. However, to date, no studies have systematically identified which practices qualify as low-value. This scoping review aims to synthesize existing evidence on LVC in PI management to inform research priorities and clinical improvements. Method We conducted a comprehensive search of PubMed, Embase, Web of Science, CINAHL, CNKI, Wanfang, VIP, and CBM databases up to December 10, 2024, to identify eligible articles. Two reviewers independently screened the abstracts and full texts, with conflicts resolved through discussion until consensus was reached. Data were extracted using a piloted data-charting form. Results Of the 1884 publications screened, 25 met the inclusion criteria. The focus areas of the included articles included PI prevention (n = 13), PI treatment (n = 10), and both prevention and treatment (n = 2). The identified low-value care targets were diverse. They included unrestricted practices (n = 6), dressings and topical agents (n = 4), repositioning (n = 3), support surfaces (n = 3), education (n = 2), risk assessment tools (n = 1), nutritional intervention (n = 1), electrical stimulation (n = 1), negative pressure wound therapy (n = 1), phototherapy (n = 1), electromagnetic therapy (n = 1), and therapeutic ultrasound (n = 1). Conclusions This scoping review found that some progress has been made in identifying low-value practices in PI management. However, significant gaps remain. Future research should focus on generating high-quality evidence and incorporating patient preferences to address these gaps.
C1 [Jiang, Mengyao; Wang, Xuejun; Wu, Yujie; Xiao, Yaru; Xiao, Qi; Xiong, Jie; Shang, Weiwei] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nursing, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.
   [Jiang, Mengyao; Xiao, Qi; Xiong, Jie; Shang, Weiwei] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Crit Care Med, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.
   [Wang, Xuejun] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Tradit Chinese Med, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.
   [Wu, Yujie; Xiao, Yaru] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Emergency Med, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology
RP Shang, WW (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nursing, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.; Shang, WW (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Crit Care Med, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.
EM jiangmengyao0516@163.com; 2458132465@qq.com; 2254178085@qq.com;
   178706345@qq.com; 68186187@qq.com; 914808880@qq.com; 55329463@qq.com
FU Nursing Research Special Fund Project of Tongji Hospital
FX We would like to thank Kaiyan Hu for her assistance.
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   Wu YJ, 2024, INT WOUND J, V21, DOI 10.1111/iwj.14843
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   Zimmerman JJ, 2021, CRIT CARE MED, V49, P472, DOI 10.1097/CCM.0000000000004876
NR 58
TC 0
Z9 0
U1 5
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD OCT 8
PY 2025
VL 25
IS 1
AR 1327
DI 10.1186/s12913-025-13519-6
PG 16
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 8KR6P
UT WOS:001590965500007
PM 41063148
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lumsden, EJ
   Kimble, RM
   Ware, RS
   Griffin, B
AF Lumsden, Emma J.
   Kimble, Roy M.
   Ware, Robert S.
   Griffin, Bronwyn
TI The impact of decreasing acute burn re-epithelialisation time utilising
   Negative Pressure Wound Therapy on morbidity: A modelled, retrospective
   cohort study
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy; Burn; Paediatric; Re-epithelialisation;
   Depth
AB Introduction: Negative pressure wound therapy (NPWT) that is applied to an acute, paediatric burn at the initial debridement may decrease re-epithelialisation time by approximately 22 %. The clinical significance of this reduction is unknown. In addition, the implication of burn variables such as depth in conjunction with NPWT have not been considered. The aim of this study was to model the effect NPWT may have on burn morbidity by reducing re-epithelialisation time by 22 % when stratified by depth. Methods: This modelled study used retrospective data from a single Australian quaternary paediatric burns unit. Data were from 2014-2016, the final period before NPWT was introduced into routine, acute burn care. Burn depths were defined as superficial partial thickness (SPT), deep dermal partial thickness (DPT), and full thickness (FT). The outcome was the effect reducing time to re-epithelialisation by 22 % had on therapeutic morbidity, stratified via depth. Results: Overall, 803 participants were included. The odds ratio of being referred to scar clinic increased by 7.6 (95 % CI 4.4-13.1; p <0.001) for each incremental increase in burn depth. For DPT burns, the mean time to reepithelialisation was 21.4 days (SE 0.7), and 134 (65.7 %) participants were referred to scar outpatient clinic. Modelled data demonstrated a 67.2 % (95 % CI 58.8-75.6) probability of scar outpatient clinic referral at day 21. When reducing re-epithelialisation time by 22 %, DPT burns re-epithelialised on day 16, which reduced the probability of scar outpatient clinic referral by 22.3 % (44.9 %, 95 % CI 35.6-54.3 %, p < 0.001). Reducing time to re-epithelialisation by 22 % had minimal impact on SPT and FT burn morbidity. Conclusion: The addition of NPWT as an acute, paediatric burn care adjunct is likely to have a clinically significant impact on DPT burn morbidity.
C1 [Lumsden, Emma J.; Kimble, Roy M.] Griffith Univ, Fac Hlth, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
   [Lumsden, Emma J.; Kimble, Roy M.; Griffin, Bronwyn] Queensland Childrens Hosp, Dept Paediat Surg Urol Burns & Trauma, Stanley St, South Brisbane, Qld 4101, Australia.
   [Lumsden, Emma J.; Kimble, Roy M.; Griffin, Bronwyn] Ctr Childrens Hlth Res, 62 Graham St, South Brisbane, Qld 4101, Australia.
   [Ware, Robert S.] Griffith Hlth, Griffith Biostat Unit, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
   [Griffin, Bronwyn] Griffith Univ, Sch Nursing & Midwifery, Hlth Grp, Nathan, Qld 4111, Australia.
C3 Griffith University; Childrens Health Queensland Hospital & Health
   Service; Queensland Childrens Hospital; Griffith University
RP Lumsden, EJ (通讯作者)，Griffith Univ, Fac Hlth, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
EM emma.lumsden@health.qld.gov.au
RI ; Griffin, Bronwyn/AEB-6299-2022; Ware, Robert/B-2024-2014; Kimble,
   Roy/B-4160-2011
OI Luden, Emma/0000-0002-5437-9701; Griffin, Bronwyn/0000-0002-6182-9125;
   Ware, Robert/0000-0002-6129-6736; 
CR Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
   Brown NJ, 2014, BURNS, V40, P751, DOI 10.1016/j.burns.2013.09.027
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Chipp E, 2017, BURNS TRAUMA, V5, DOI 10.1186/s41038-016-0068-2
   Frear CC, 2020, BJS-BRIT J SURG, V107, P1741, DOI 10.1002/bjs.11993
   Ichioka S, 2008, WOUND REPAIR REGEN, V16, P460, DOI 10.1111/j.1524-475X.2008.00390.x
   Kairinos N, 2010, J PLAST RECONSTR AES, V63, P174, DOI 10.1016/j.bjps.2008.08.037
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
   Monstrey S, 2008, BURNS, V34, P761, DOI 10.1016/j.burns.2008.01.009
   Morykwas MJ, 1999, J BURN CARE REHABIL, V20, P15, DOI 10.1097/00004630-199901001-00003
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Tapking C, 2024, BURNS, V50, P1840, DOI 10.1016/j.burns.2024.04.005
   Yuan Y, 2019, J SURG RES, V235, P329, DOI 10.1016/j.jss.2018.09.065
NR 14
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD NOV
PY 2025
VL 51
IS 8
AR 107621
DI 10.1016/j.burns.2025.107621
EA JAN 2025
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 8MK0Z
UT WOS:001592126100001
PM 40834480
DA 2026-07-24
ER
PT J
AU Wang, JC
   Wan, ZP
   Ma, XW
AF Wang, Jianchuan
   Wan, Zongpu
   Ma, Xiaowei
TI A strategy for the one-stage treatment of open Pilon fractures based on
   an accelerated rehabilitation surgical concept
SO CIRUGIA Y CIRUJANOS
LA English
DT Article
DE Open Pilon fracture; Emergency incisional reduction and internal
   fixation; Vacuum sealing drainage; Accelerated rehabilitation surgery
ID INTERNAL-FIXATION; EXTERNAL FIXATION; OPEN REDUCTION; INFECTION;
   MANAGEMENT; DEBRIDEMENT
AB Objective: The objective of the study was to study the strategy of one-stage emergency treatment of open Pilon fracture with the concept of accelerated rehabilitation surgery. Methods: The data of 18 patients with open Pilon fracture treated by first-stage emergency debridement, fracture internal fixation, bone grafting, negative pressure closed drainage covering the wound, leg incision reduction, and second-stage skin grafting or flap transfer in the Department of Orthopedics of our hospital from January 2014 to December 2018 were retrospectively analyzed. Joint surface reduction was evaluated by radiological evaluation criteria such as Burwell-Charnley, fracture healing quality was evaluated by Merchant score, and ankle joint function was evaluated by Tornetta and other criteria at the last follow-up. Results: All 18 patients were followed up, and the anatomical reduction rate was 94% (17/18) according to radiological evaluation criteria such as Burwell-Charnley. According to Merchant scoring criteria, the fracture healing rate was 83.3% (15/18). At the last follow-up, the ankle function was evaluated according to Tornetta and other criteria, and the excellent rate was 88.9% (16/18). Conclusions: Using the concept of accelerated rehabilitation surgery to treat open Pilon fractures in the first emergency can effectively avoid soft-tissue complications and is an effective treatment strategy.
C1 [Wang, Jianchuan; Wan, Zongpu; Ma, Xiaowei] Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China.
C3 Dalian University
RP Ma, XW (通讯作者)，Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China.
EM 2573131767@qq.com
FU General Program from the Educational Commission of Liaoning Province of
   China [LJKZ0500]
FX The authors declare that they have received Funding. This research is
   financially funded by the General Program from the Educational
   Commission of Liaoning Province of China (Grant No. LJKZ0500) .
CR Al-Hourani K, 2019, J ORTHOP TRAUMA, V33, P591, DOI 10.1097/BOT.0000000000001562
   Bin Y, 2019, Chinese J Trauma Orthop, V21, P921
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   Fang Li-Ming, 2011, Zhonghua Yi Xue Za Zhi, V91, P2329
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   Mathews JA, 2015, INJURY, V46, P2263, DOI 10.1016/j.injury.2015.08.027
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   Riechelmann F, 2018, OPER ORTHOP TRAUMATO, V30, P294, DOI 10.1007/s00064-018-0562-8
   Sirkin M, 2004, J ORTHOP TRAUMA, V18, pS32, DOI 10.1097/00005131-200409001-00005
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NR 29
TC 0
Z9 0
U1 2
U2 2
PU MEXICAN ACAD SURGERY
PI MEXICO D G
PA CENTRO MED NAC SIGLO XXI, EDIFICIO BLOQUE B, SOTANO, AVE CUAUHTEMOC NO
   330, MEXICO D G, 06700, MEXICO
SN 0009-7411
J9 CIR CIR
JI Cir. Cir.
PD SEP-OCT
PY 2025
VL 93
IS 5
BP 474
EP 482
DI 10.24875/CIRU.24000013
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8ML9J
UT WOS:001592174200002
PM 40614248
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pharr, T
   Billingsley, J
   Docimo, S
AF Pharr, Trevor
   Billingsley, Jenna
   Docimo, Salvatore
TI Successful salvage of bioresorbable mesh (Poly-4-hydroxybutyrate)
   following complicated hernia repair: a case series and systematic review
SO HERNIA
LA English
DT Article
DE Bioresorbable mesh; Mesh salvage; Ventral hernia repair;
   Poly-4-hydroxybutyrate
AB PurposeBioresorbable mesh is becoming increasingly common in complex cases. However, the outcomes of mesh salvage following complicated hernia repair with bioresorbable mesh have not been well-characterized. We report a series of three cases involving the salvage of poly-4-hydroxybutyrate (P4HB) bioresorbable mesh following ventral hernia repair (VHR).MethodsWe conducted a systematic review of the literature to elicit current outcomes of hernia mesh salvage in VHR using bioresorbable mesh. We then included patients who presented with postoperative complications following VHR using P4HB mesh at Tampa General Hospital (TGH).ResultsNineteen cases of bioresorbable mesh salvage following VHR are reported in existing literature, with varying success rates. Three reported cases of mesh complication with P4HB at TGH were analyzed. The mean time to hospital presentation for postoperative complications was 37.3 days, with a median of 30 days. Complications included dehiscence (3/3 cases), infection (2/3 cases), necrosis (2/3 cases), and exposed mesh (2/3 cases). Postoperative procedures included incision and drainage (2/3 cases) and debridement (2/3 cases). Mesh salvage was successful in all cases. Complete mesh removal was not required in any case. Negative pressure wound therapy (NPWT) was utilized in all cases after wound dehiscence and complication. One patient experienced chronic diarrhea and incomplete wound closure after 12 months. There were no instances of hernia recurrence.ConclusionMesh complications are inevitable in a percentage of complex hernia repairs. Salvage of P4HB mesh in complicated VHR was successful in all reported cases at our institution.
C1 [Pharr, Trevor; Billingsley, Jenna; Docimo, Salvatore] Univ S Florida, USF Hlth Morsani Coll Med, 560 Channelside Dr, Tampa, FL 33602 USA.
   [Docimo, Salvatore] USF Hlth, Dept Gen Surg, Tampa, FL USA.
   [Docimo, Salvatore] Univ S Florida, Dept Gastrointestinal Surg, USF Hlth, Tampa, FL USA.
C3 State University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida
RP Pharr, T (通讯作者)，Univ S Florida, USF Hlth Morsani Coll Med, 560 Channelside Dr, Tampa, FL 33602 USA.
EM trevorpharr@gmail.com
OI Pharr, Trevor/0009-0001-9255-390X; Billingsley,
   Jenna/0009-0005-0431-7405
CR Ahmed A, 2024, HERNIA, V28, P575, DOI 10.1007/s10029-023-02951-4
   Al-Mansour MR, 2024, AM J SURG, V233, P100, DOI 10.1016/j.amjsurg.2024.02.028
   Christopher AN, 2021, PLAST RECONSTR SURG, V148, P1367, DOI 10.1097/PRS.0000000000008579
   Claessen JJM, 2021, HERNIA, V25, P1647, DOI 10.1007/s10029-021-02415-7
   Dickson D, 2024, COLORECTAL DIS, V26, P632, DOI 10.1111/codi.16913
   Holihan JL, 2017, SURG INFECT, V18, P647, DOI 10.1089/sur.2017.029
   Kao AM, 2018, PLAST RECONSTR SURG, V142, p149S, DOI 10.1097/PRS.0000000000004871
   Li JS, 2022, ANZ J SURG, V92, P2448, DOI 10.1111/ans.18040
   Martin DP, 2013, J SURG RES, V184, P766, DOI 10.1016/j.jss.2013.03.044
   Pauli E, 2020, INT J ABDOM WALL HER, V3, P4, DOI [10.4103/ijawhs.ijawhs_47_19, 10.4103/ijawhs.ijawhs_47_19, DOI 10.4103/IJAWHS.IJAWHS_47_19]
   Siddiqui A, 2023, J SURG RES, V291, P603, DOI 10.1016/j.jss.2023.07.003
   Smith J, 2020, Ventral Hernia
   Stremitzer S, 2010, WORLD J SURG, V34, P1702, DOI 10.1007/s00268-010-0543-z
   Warren JA, 2020, AM J SURG, V220, P751, DOI 10.1016/j.amjsurg.2020.01.028
NR 14
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD OCT 13
PY 2025
VL 29
IS 1
AR 293
DI 10.1007/s10029-025-03478-6
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8NJ2G
UT WOS:001592784000002
PM 41081958
DA 2026-07-24
ER
PT J
AU Madueke, M
   Lau, F
AF Madueke, Michael
   Lau, Frank
TI Synthetic Electrospun Fiber Matrix in the Management of Acute Wounds
   Following Excision of Hidradenitis Suppurativa Lesions: A Prospective
   Pilot Study
SO POLYMERS
LA English
DT Article
DE tissue regeneration; hidradenitis suppurativa; surgical wound; synthetic
   matrix; synthetic electrospun fiber matrix; skin grafting; infection;
   dermal regeneration; electrospinning
ID OUTCOMES
AB Hurley Stage II or III hidradenitis suppurativa (HS) may necessitate surgical excision of diseased skin and subcutaneous fat for symptom control and disease management. These excisions result in open wounds in topographically challenging regions and typically cannot be primarily closed. This study evaluates the use of a synthetic electrospun fiber matrix (SEFM) as a post-resection regeneration template to accelerate re-granulation and improve subsequent skin graft incorporation. This prospective pilot study enrolled Hurley Stage II or III patients undergoing surgical resection of HS lesions. SEFM was applied to the resulting wounds in conjunction with negative pressure wound therapy (NPWT). Patients were monitored post-operatively for granulation tissue formation and underwent skin grafting once granulation was sufficient. Skin graft incorporation was assessed at follow-up visits. Complications, including graft loss (partial or complete) and infection, were assessed at each encounter. A total of 21 wounds in eight patients met the inclusion criteria and were enrolled. The average time to skin grafting was 14 +/- 3.2 days. After grafting, the average graft incorporation was 71 +/- 28%. No complications occurred during the study. These initial results indicate that by supporting granulation tissue formation, combined use of SEFM and NPWT may aid in successful engraftment of topographically challenging areas post-HS excision.
C1 [Madueke, Michael] Tulane Univ, Sch Med, 1430 Tulane Ave, New Orleans, LA 70112 USA.
   [Lau, Frank] Keliomics Inc, 4640 S Macadam Ave, Portland, OR 97239 USA.
   [Lau, Frank] Louisiana State Univ, Hlth Sci Ctr, Dept Surg, Sect Plast & Reconstruct Surg, 1542 Tulane Ave, New Orleans, LA 70112 USA.
C3 Tulane University; Tulane University; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans
RP Lau, F (通讯作者)，Keliomics Inc, 4640 S Macadam Ave, Portland, OR 97239 USA.; Lau, F (通讯作者)，Louisiana State Univ, Hlth Sci Ctr, Dept Surg, Sect Plast & Reconstruct Surg, 1542 Tulane Ave, New Orleans, LA 70112 USA.
EM umadueke@tulane.edu; frankhlau@gmail.com
FU Acera Surgical Inc.; LSU Health Foundation New Orleans
FX This research was funded by Acera Surgical Inc., in the form of an
   unrestricted grant agreement with LSU Health Foundation New Orleans. The
   company was not involved in the study design, collection, analysis,
   interpretation of data, the writing of this article or the decision to
   submit it for publication.
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   Martini CJ, 2022, Foot & Ankle Surgery Techniques Reports & Cases, V2, P100112, DOI [10.1016/j.fastrc.2021.100112, 10.1016/j.fastrc.2021.100112, DOI 10.1016/J.FASTRC.2021.100112]
   Mason SA, 2023, J BURN CARE RES, V44, pS19, DOI 10.1093/jbcr/irac135
   Michelucci A, 2023, HEALTH SCI REP-US, V6, DOI 10.1002/hsr2.1582
   Ngaage LM, 2020, INT WOUND J, V17, P117, DOI 10.1111/iwj.13241
   Ovadja ZN, 2019, BRIT J DERMATOL, V181, P344, DOI 10.1111/bjd.17588
   Rajaram R, 2024, FRONT BIOENG BIOTECH, V12, DOI 10.3389/fbioe.2024.1450973
   Reaulski MJ, 2018, WOUNDS, V30, pE77
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   Shukla R, 2022, J CLIN MED, V11, DOI 10.3390/jcm11092311
   Taupin P, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.38608
   Torabi R, 2018, J AM COLL SURGEONS, V227, pE144, DOI 10.1016/j.jamcollsurg.2018.08.393
   Vellaichamy G, 2018, CUTIS, V102, P13
   Wieczorek Marta, 2018, Reumatologia (Warsaw), V56, P337, DOI [10.5114/reum.2018.80709, 10.5114/reum.2018.80709]
   Wu SS, 2022, WOUNDS, V34, P106, DOI 10.25270/wnds/2022.106115
NR 41
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4360
J9 POLYMERS-BASEL
JI Polymers
PD SEP 23
PY 2025
VL 17
IS 19
AR 2563
DI 10.3390/polym17192563
PG 11
WC Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Polymer Science
GA 8OL7H
UT WOS:001593528000001
PM 41096209
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Dal Pos, S
   Tafaj, S
   Hoxhaj, I
   Cassalia, F
   Russano, F
   Tropea, S
   Del Fiore, P
   Mazza, M
AF Dal Pos, Silvia
   Tafaj, Stela
   Hoxhaj, Ilda
   Cassalia, Fortunato
   Russano, Francesco
   Tropea, Saveria
   Del Fiore, Paolo
   Mazza, Marcodomenico
TI The Safety of Negative-Pressure Wound Therapy in Melanoma and Sarcoma
   Patients: A Systematic Review
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE negative-pressure wound therapy; melanoma; sarcoma; malignant wounds
ID SOFT-TISSUE SARCOMAS; ACRAL LENTIGINOUS MELANOMA; EXCISION;
   RECONSTRUCTION; DRESSINGS; RESECTION
AB Background/Objectives: Negative-Pressure Wound Therapy (NPWT) is increasingly used to promote wound healing in chronic and complicated wounds, but its use in surgical oncology is still debated due to theoretical concerns about promoting local tumor recurrence. The aim of this study is to review the available evidence on the oncologic safety of NPWT, specifically regarding the risk of local recurrence in patients undergoing surgery for cutaneous melanoma (CM) or soft tissue sarcoma (STS). Methods: A systematic review of the literature was conducted using the MEDLINE/PubMed, EMBASE, and Scopus databases through December 2024 (PROSPERO: CRD42024623405). Case series, retrospective cohort studies, and randomized clinical trials reporting survival data in melanoma and sarcoma patients treated with NPWT were eligible for inclusion. PRISMA guidelines were followed and quality assessment checked. Results: Seventeen studies were eligible for the analysis with a total of 285 patients, 197 affected by soft tissue sarcoma and 88 by cutaneous melanoma. The pooled proportion of local recurrence was 5% in patients treated with NPWT, regardless of the histology considered (STS and CM). When comparing NPWT to conventional wound therapy, both the pooled risk ratio (0.87; 95% CI: 0.24-3.11; Tau2 = 0.14; I2 = 8%) and odds ratio (0.83; 95% CI: 0.20-3.39; Tau2 = 0.18) indicated no statistically significant difference in the recurrence rate. Conclusions: Current evidence does not suggest an increased risk of local recurrence associated with NPWT in melanoma or sarcoma patients, and mostly, NPWT may have important advantages over standard surgical dressings. More high-power randomized controlled trials with wider follow-up periods are needed to make it possible for practitioners to use this technique without being afraid of higher risk local recurrences.
C1 [Dal Pos, Silvia; Russano, Francesco; Tropea, Saveria; Del Fiore, Paolo; Mazza, Marcodomenico] Veneto Inst Oncol IOV IRCCS, Soft Tissue Peritoneum & Melanoma Surg Oncol Unit, I-35128 Padua, Italy.
   [Tafaj, Stela] Univ Padua, Dept Surg Oncol & Gastroenterol Sci DISCOG, I-35128 Padua, Italy.
   [Hoxhaj, Ilda] Fdn Policlin Univ Agostino Gemelli, Ist Ricovero & Cura Carattere Sci IRCCS, Dept Med & Surg Sci, I-00168 Rome, Italy.
   [Cassalia, Fortunato] Univ Padua, Dept Med DIMED, Dermatol Unit, I-35121 Padua, Italy.
C3 IRCCS Istituto Oncologico Veneto (IOV); University of Padua; Catholic
   University of the Sacred Heart; IRCCS Policlinico Gemelli; University of
   Padua
RP Del Fiore, P (通讯作者)，Veneto Inst Oncol IOV IRCCS, Soft Tissue Peritoneum & Melanoma Surg Oncol Unit, I-35128 Padua, Italy.
EM silvia.dalpos@iov.veneto.it; paolo.delfiore@iov.veneto.it;
   marcodomenico.mazza@iov.veneto.it
RI HOXHAJ, Ilda/JFB-1110-2023; Del Fiore, Paolo/X-7536-2018; Cassalia,
   Fortunato/ITV-9685-2023; mazza, marcodomenico/KAL-9409-2024
OI HOXHAJ, Ilda/0000-0001-7086-2456; Del Fiore, Paolo/0000-0002-2862-8014;
   Cassalia, Fortunato/0000-0002-5014-1122; mazza,
   marcodomenico/0000-0002-4575-0548
FU Italian Ministry of Health
FX This research received no external funding, and the APC was funded by
   "Current Research" funds from the Italian Ministry of Health to cover
   publication.
CR Agostini T, 2013, J CRANIO MAXILL SURG, V41, P681, DOI 10.1016/j.jcms.2013.01.009
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NR 36
TC 0
Z9 0
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT 5
PY 2025
VL 14
IS 19
AR 7044
DI 10.3390/jcm14197044
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8OS9X
UT WOS:001593717400001
PM 41096124
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Seswandhana, MR
   Humani, HMA
   Gabriela, GC
   Dachlan, I
   Liana, E
   Wirohadidjojo, YW
   Aryandono, T
   Mulyono, B
   Widodo, I
AF Seswandhana, Muhammad Rosadi
   Humani, Hamim Majdy Awliya
   Gabriela, Gita Christy
   Dachlan, Ishandono
   Liana, Estelita
   Wirohadidjojo, Yohanes Widodo
   Aryandono, Teguh
   Mulyono, Budi
   Widodo, Irianiwati
TI The impact of negative pressure wound therapy on epidermal stem cells
   and keratinocyte growth factor in deep dermal burn injury: An
   experimental study
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy (NPWT); Wound healing; Burn management;
   Burn injury; Epidermal stem cell (ESC)
AB Introduction: Burns are the fourth most common accidental injury worldwide, predominantly occurring in developing countries. Wound healing in burns involves reduced cytokine secretion but increased chemokine and growth factor production compared to surgical wounds. Keratinocyte growth factor (KGF) regulates epidermal regeneration, an essential process in wound healing; while epidermal stem cells (ESCs) play a crucial role in wound closure and have potential for cell therapy. Negative pressure wound therapy (NPWT) promotes healing by improving blood flow, enhancing re-epithelialization, and reducing infection risk. This study investigates the effects of NaCl 0.9 %, intermittent and continuous NPWT, and silver sulfadiazine on ESC and KGF levels in deep dermal burns. Method: Six male Yorkshire pigs received 20 deep dermal burns on the flank and dorsum, divided into four treatment groups: NaCl 0.9 %, continuous NPWT, intermittent NPWT, and silver sulfadiazine. Samples were collected on days 1, 3, 7, 14, and 21. ESCs were evaluated using CK19 immunohistochemistry as a marker. KGF levels were measured via ELISA. Data were analyzed with ANOVA, with significance set at p < 0.05. Result: Continuous NPWT showed the highest ESC counts at the wound edge on all observation days and at the wound center on days 3 and 21, though without statistical significance. KGF levels differed significantly among the groups on days 1, 3, and 7 (p < 0.05), with the continuous NPWT group consistently showing the highest KGF levels. Statistical analysis revealed that treatment, observation day, and KGF levels significantly influenced ESC counts, accounting for 45 % of the variability (p < 0.05). Conclusion: The continuous NPWT group demonstrated significantly elevated KGF levels on days 1, 3, and 7, which corresponded to a significant increase in ESC. Further research is warranted to confirm these findings.
C1 [Seswandhana, Muhammad Rosadi; Humani, Hamim Majdy Awliya; Gabriela, Gita Christy; Dachlan, Ishandono; Liana, Estelita] Dr Sardjito Hosp, Publ Hlth & Nursing Univ Gadjah Mada, Div Plast Reconstruct & Aesthet Surg, Dept Surg ,Fac Med, Yogyakarta 55281, Indonesia.
   [Wirohadidjojo, Yohanes Widodo] Dr Sardjito Hosp, Publ Hlth & Nursing Univ Gadjah Mada, Fac Med, Dept Dermatol & Venerol, Yogyakarta 55281, Indonesia.
   [Aryandono, Teguh] Univ Gadjah Mada, Dr Sardjito Hosp, Fac Med Publ Hlth & Nursing, Dept Clin Pathol, Yogyakarta 55281, Indonesia.
   [Mulyono, Budi] Dr Sardjito Hosp, Publ Hlth & Nursing Univ Gadjah Mada, Dept Clin Pathol, Fac Med, Yogyakarta 55281, Indonesia.
   [Widodo, Irianiwati] Dr Sardjito Hosp, Publ Hlth & Nursing Univ Gadjah Mada, Dept Anat Pathol, Dept Surg,Fac Med, Yogyakarta 55281, Indonesia.
C3 Central General Hospital Dr. Sardjito; Central General Hospital Dr.
   Sardjito; Gadjah Mada University; Central General Hospital Dr. Sardjito;
   Central General Hospital Dr. Sardjito; Central General Hospital Dr.
   Sardjito
RP Seswandhana, MR (通讯作者)，Dr Sardjito Hosp, Publ Hlth & Nursing Univ Gadjah Mada, Div Plast Reconstruct & Aesthet Surg, Dept Surg ,Fac Med, Yogyakarta 55281, Indonesia.
EM rosadi_seswandhana@ugm.ac.id
RI Seswandhana, Rosadi/AAH-4064-2020
OI Seswandhana, Rosadi/0000-0002-5138-7802
FU Universitas Gadjah Mada [280/UN1/FK-KMK/PP/PT/2020]
FX The author (s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by research grants from Universitas Gadjah Mada. Number:
   280/UN1/FK-KMK/PP/PT/2020.
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NR 30
TC 3
Z9 3
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD DEC
PY 2025
VL 51
IS 9
AR 107719
DI 10.1016/j.burns.2025.107719
EA OCT 2025
PG 7
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 8PO7V
UT WOS:001594286500001
PM 41061528
DA 2026-07-24
ER
PT J
AU Tsouknidas, I
   Tibbets, G
   Angistriotis, A
   Koullias, G
AF Tsouknidas, Ioannis
   Tibbets, Garrett
   Angistriotis, Athanasios
   Koullias, George
TI A Multimodal Approach for Limb Preservation of Dehisced Amputations with
   Bone Exposure
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID LOWER-EXTREMITY AMPUTATION; RISK-FACTORS; READMISSION; DISEASE
AB Background: The prevalence of nontraumatic amputations continues to rise annually. The length of the preserved limb is directly associated with the success of ambulation. Wound infections after lower extremity amputations are very common, and reoperation is necessary in up to 61%. When dehisced stumps are complicated by bone exposure and osteomyelitis, more proximal amputation is traditionally performed. Methods: A retrospective chart review of the electronic medical records from 2018 to 2024 was conducted at our institution, and dehisced amputated stumps with bone exposure were included for final analysis. All cases were treated with a novel seven-step treatment algorithm, incorporating aggressive revascularization, as well as standard and advanced wound care modalities. Data collection included patient characteristics, treatment details, and follow-up outcomes. Results: A total of 22 dehisced stumps with osteomyelitis, from 19 patients (73.7% male, 26.3% female), with an average wound size of 27.4 cm(2) were included. Fourteen revascularization procedures were performed. Negative pressure wound therapy, collagen products, and amniotic or acellular matrix dressings were used in 54.5%, 68.2%, and 72.7% of the stumps, respectively. Complete healing was achieved in all patients with an average healing time of 171.8 days. Wound recurrence occurred in two stumps. The mean wound-free period was 323.9 days. Conclusion: The proposed treatment algorithm enables successful closure of dehisced stumps with bone exposure in selected patients. Adherence to the treatment and close follow-up are essential for optimal outcomes.
C1 [Tsouknidas, Ioannis] Lankenau Med Ctr, Dept Surg, Wynnewood, PA USA.
   [Tsouknidas, Ioannis; Tibbets, Garrett; Angistriotis, Athanasios; Koullias, George] Stony Brook Southampton Hosp, Dept Surg, Southampton, NY USA.
   [Tsouknidas, Ioannis; Tibbets, Garrett; Angistriotis, Athanasios] Stony Brook Univ Hosp, Dept Surg, Stony Brook, NY USA.
   [Koullias, George] Stony Brook Univ Hosp, Dept Surg, Div Vasc & Endovascular Surg, Stony Brook, NY USA.
   [Koullias, George] Stony Brook Univ Hosp, Limb Preservat Ctr, Div Vasc & Endovascular Surg, Stony Brook, NY USA.
   [Koullias, George] Catholic Hlth Syst, St Catherine Siena Hosp, Div Vasc & Endovascular Surg, Catholic Hlth Syst Chief Limb Preservat, Smithtown, NY USA.
C3 Lankenau Medical Center; State University of New York (SUNY) System;
   Stony Brook University; Stony Brook University Hospital; State
   University of New York (SUNY) System; Stony Brook University; Stony
   Brook University Hospital; State University of New York (SUNY) System;
   Stony Brook University; Stony Brook University Hospital
RP Koullias, G (通讯作者)，Catholic Syst, St Catherine Siena Hosp, Div Vasc & Surg, 50 NY-25A, Smithtown, NY 11787 USA.
EM gkoullias@yahoo.com
RI ; Tsouknidas, Ioannis/AAL-7816-2021
OI Tibbets, Garrett/0009-0003-8612-0053; Tsouknidas,
   Ioannis/0000-0002-5958-0404; Angistriotis,
   Athanasios/0000-0002-3954-3227
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD JAN
PY 2026
VL 122
BP 713
EP 722
DI 10.1016/j.avsg.2025.09.019
EA OCT 2025
PG 10
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 8PU6R
UT WOS:001594440800001
PM 40975212
DA 2026-07-24
ER
PT J
AU Guo, JL
   Feng, W
   Song, BJ
   Zhu, DJ
   Wen, YW
   Wang, Q
AF Guo, Jiale
   Feng, Wei
   Song, Baojian
   Zhu, Danjiang
   Wen, Yuwei
   Wang, Qiang
TI Clinical characteristics and risk factors for poor prognosis in children
   with complicated acute hematogenous osteomyelitis treated with vaccum
   sealing drainage
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Acute hematogenous osteomyelitis; Risk factors; Prognosis; Children
ID PEDIATRIC OSTEOMYELITIS; BONE; PROCALCITONIN
AB BackgroundThis study aims to analyze the clinical characteristics of children with complicated acute hematogenous osteomyelitis treated with vacuum sealing drainage (VSD) in our institution, and to explore the risk factors for poor prognosis.MethodsA retrospective analysis was performed on the medical records of patients diagnosed with acute hematogenous Osteomyelitis from December 2015 to December 2022. The demographic profiles, treatment procedures, examination results, and follow-up information of the patients were meticulously recorded. Patients were categorized into two groups based on the occurrence of treatment failure, deformity, limb length discrepancy, growth arrest, osteonecrosis, chronic osteomyelitis, pathological fracture, chondrolysis, and recurrence: good prognosis group and poor prognosis group. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors associated with adverse prognosis. The performance of the regression model was assessed using the area under the receiver operating characteristic (ROC) curve.ResultsA total of 150 patients who met the inclusion criteria were followed up for an average of 3.4 years (range: 1.0-7.0 years). There were 31 patients (21%) in the poor prognosis group. In all cases, after 7 days of continuous saline irrigation and 2 surgical debridement, 75% of the infections were completely controlled, and the local abscess disappeared in 86% of the patients. By regression analysis, leukocyte admission (adjusted odds ratio (aOR) 1.2; 95% confidence interval (CI) [1.0-1.4]; P = 0.04), first postoperative C-reactive protein level (aOR 1.04; 95% (CI), [1.0-1.07], P = 0.034), time to diagnosis of osteomyelitis (aOR 1.3; 95% (CI), [1.1-1.6], P = 0.012), and days of fever with antibiotics (aOR 1.5; 95% (CI), [1.1-2.2], P = 0.024) were independent risk factors for poor outcomes. The four variables combined to construct an efficient prediction model, with an area under the curve (AUC) of 0.85.ConclusionThe innovative application of vacuum sealing drainage technology in the management of complicated patients with substantially localized abscesses achieved significant efficacy, while one-third of children still had unfavorable outcomes. High-risk groups with recurrence and sequelae necessitate regular follow-up and even long-term orthopedic intervention.
C1 [Guo, Jiale; Feng, Wei; Song, Baojian; Zhu, Danjiang; Wen, Yuwei; Wang, Qiang] Capital Med Univ, Beijing Childrens Hosp, Dept Orthopaed, Nanlishi Rd 56, Beijing 100045, Peoples R China.
   [Guo, Jiale; Feng, Wei; Song, Baojian; Zhu, Danjiang; Wen, Yuwei; Wang, Qiang] Natl Ctr Childrens Hlth, Beijing 100045, Peoples R China.
C3 Capital Medical University
RP Wang, Q (通讯作者)，Capital Med Univ, Beijing Childrens Hosp, Dept Orthopaed, Nanlishi Rd 56, Beijing 100045, Peoples R China.; Wang, Q (通讯作者)，Natl Ctr Childrens Hlth, Beijing 100045, Peoples R China.
EM wangqiangmd@aliyun.com
FU Natural Science Foundation of Beijing Municipality
FX Firstly, I would like to express my gratitude to Professor Qiang Wang,
   my esteemed teacher, for his invaluable feedback on revisions and
   technical guidance. Wei Feng, offering formal analysis and associated
   corrections. Baojian Song, writing assistance, or proofreading the
   article. Danjiang Zhu, providing spiritual motivation and empirical
   evidence support. Yuwei Wen, assisting with ideas, language creating
   illustrations, and generating tables. The study was conducted without
   any financial support. Thank you immensely for your invaluable
   assistance.
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NR 31
TC 2
Z9 2
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD OCT 14
PY 2025
VL 26
IS 1
AR 963
DI 10.1186/s12891-025-09094-w
PG 11
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA 8QI2R
UT WOS:001594798000003
PM 41088318
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ramírez-Giraldo, C
   Rincón-Nieto, N
   Hernández-Vesga, J
   Turizo, JL
   Pesce, A
   Agudelo-Delgadillo, D
   Santamaría-Forero, S
   Isaza-Restrepo, A
AF Ramirez-Giraldo, Camilo
   Rincon-Nieto, Nicolas
   Hernandez-Vesga, Julian
   Turizo, Jorge Luis
   Pesce, Antonio
   Agudelo-Delgadillo, Daniel
   Santamaria-Forero, Sofia
   Isaza-Restrepo, Andres
TI Mesh-mediated fascial traction for open abdomen management to prevent
   planned ventral hernias: a retrospective cohort
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Open abdomen; Mesh-mediated fascial traction; Negative pressure wound
   therapy; Incisional hernia; Abdominal wall closure
ID PRESSURE WOUND THERAPY; CLOSURE
AB BackgroundOpen abdomen is indicated in some clinical scenarios, but it introduces new challenges like the development of planned incisional hernias; new management techniques for temporary closure in open abdomen such as negative pressure wound therapy and mesh-mediated fascial traction have shown an incidence reduction of this outcome. However, for successful abdominal wall closure rates, there is limited evidence evaluating the factors associated with it when mesh-mediated fascial traction is employed in the context of open abdomen.MethodsWe conducted a retrospective cohort analysis of patients managed with mesh-mediated fascial traction at M & eacute;deri Hospital Network from 2020 to 2025. Demographic data, clinical characteristics, surgical variables, and postoperative outcomes were systematically evaluated.ResultsNinety-two patients were included, achieving a definitive abdominal wall closure success rate of 70.7%. Closure failure was significantly correlated with more than four peritoneal lavage procedures, intestinal resection, and initial fascial defects greater than 7.5 cm. Primary indications for OA management were peritonitis/sepsis (34.8%) and bowel obstruction (19.6%).ConclusionsMesh-mediated fascial traction is effective for definitive abdominal wall closure in a majority of patients. However, identifying those at increased risk for closure failure is vital. Utilizing a tailored decision-making algorithm based on specific predictors can optimize clinical outcomes and reduce healthcare costs.
C1 [Ramirez-Giraldo, Camilo; Turizo, Jorge Luis; Isaza-Restrepo, Andres] Hosp Univ Mayor Mederi, Calle 24 29-45, Bogota, Colombia.
   [Ramirez-Giraldo, Camilo; Rincon-Nieto, Nicolas; Hernandez-Vesga, Julian; Turizo, Jorge Luis; Agudelo-Delgadillo, Daniel; Santamaria-Forero, Sofia; Isaza-Restrepo, Andres] Univ Rosario, Bogota, Colombia.
   [Pesce, Antonio] Univ Ferrara, Dept Surg, Azienda Un Sanit Locale Ferrara, Ferrara, Italy.
C3 Universidad del Rosario; University of Ferrara
RP Ramírez-Giraldo, C (通讯作者)，Hosp Univ Mayor Mederi, Calle 24 29-45, Bogota, Colombia.; Ramírez-Giraldo, C (通讯作者)，Univ Rosario, Bogota, Colombia.
EM ramirezgiraldocamilo@gmail.com; nicolas.rinconn@urosario.edu.co;
   julian.13andres@gmail.com; turizo0324@hotmail.com;
   antonio.pesce@unife.it; daniel.agudelod@gmail.com;
   ssantamariaf1@gmail.com; andres.isaza@urosario.edu.co
RI ; Ramírez-Giraldo, Camilo/LRV-0499-2024; PESCE, ANTONIO/G-4536-2017;
   Isaza-Restrepo, Andres/K-1790-2016
OI Santamaria- Forero, Sofia/0000-0002-0288-7915; Ramírez-Giraldo,
   Camilo/0000-0002-1929-2299; PESCE, ANTONIO/0000-0002-7560-551X;
   Hernández-Vesga, Julián/0000-0001-6010-6833; 
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NR 24
TC 1
Z9 1
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD OCT 16
PY 2025
VL 410
IS 1
AR 301
DI 10.1007/s00423-025-03871-w
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8QS3Q
UT WOS:001595060700003
PM 41099855
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Li, XJ
   Zhang, YR
   Xiong, F
   Li, JY
   Qi, SL
   Wang, QB
   Mu, SJ
   Cao, D
   Niu, S
   Liu, W
   Liu, LC
   Zhang, ZT
AF Li, Xinjian
   Zhang, Yuru
   Xiong, Fang
   Li, Jiayan
   Qi, Shunli
   Wang, Qingbo
   Mu, Shijia
   Cao, Di
   Niu, Shuo
   Liu, Wei
   Liu, Liancheng
   Zhang, Zhongtao
TI Comparison between vacuum sealing drainage (VSD) and conventional
   dressing for fournier's gangrene: a single-centre retrospective study
SO BMC SURGERY
LA English
DT Article
DE Fournier's gangrene (FG); Vacuum sealing drainage (VSD); Laboratory risk
   indicator for necrotizing fasciitis (LRINEC) scoring system; inverse
   probability of treatment weight (IPTW)
ID NECROTIZING FASCIITIS; ASSISTED CLOSURE; WOUND THERAPY; MANAGEMENT
AB BackgroundFournier's gangrene (FG) is a life-threatening infection associated with high mortality and often necessitates urgent surgical intervention. Vacuum sealing drainage (VSD) has emerged as a promising adjunct to surgical debridement; however, its impact on antibiotic stewardship remains inadequately studied. This study compares the efficacy of VSD and conventional dressings in the management of FG. MethodsIn this single-center retrospective study, 104 patients with Fournier's gangrene (FG) treated between January 2022 and December 2023 were analyzed. Patients were categorized into VSD (n = 42) and conventional dressing (n = 62) groups following surgical debridement. Data included demographics, comorbidities, infection sites, Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) scores, antibiotic duration, and clinical outcomes. Inverse probability of treatment weighting (IPTW) was applied to mitigate confounding biases. ResultsBefore IPTW adjustment, the VSD group exhibited longer durations in key clinical outcomes compared to the control group, including time to leukocyte normalization (+ 1.6 days), antibiotic use (+ 2.0 days), and hospital stay (+ 2.0 days). After IPTW adjustment, all three indicators showed improvement in favor of the VSD group. Generalized weighted regression further confirmed that VSD was associated with significant clinical benefits: shortened time to leukocyte normalization (mean difference: -1.8 days; 90% CI: -3.5 to -0.1), reduced duration of antibiotic therapy (-2.0 days; 90% CI: -3.7 to -0.4), and decreased length of hospitalization (-3.0 days; 90% CI:-5.7 to -0.4).Post-IPTW, VSD emerged as a protective factor, with all standardized mean differences (SMDs) remaining below 0.2, indicating acceptable covariate balance. ConclusionsVSD may improve clinical outcomes in patients with Fournier's gangrene by accelerating recovery and reducing antibiotic use and length of hospitalization. These benefits appear more pronounced in patients with high LRINEC scores or extensive infections. Nevertheless, individualized treatment strategies should consider systemic disease severity, such as the Fournier's Gangrene Severity Index (FGSI).
C1 [Li, Xinjian; Zhang, Zhongtao] Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China.
   [Li, Xinjian; Zhang, Zhongtao] State Key Lab Digest Hlth, Beijing, Peoples R China.
   [Li, Xinjian; Zhang, Zhongtao] Natl Clin Res Ctr Digest, Beijing, Peoples R China.
   [Li, Xinjian; Zhang, Yuru; Mu, Shijia; Cao, Di; Niu, Shuo; Liu, Wei; Liu, Liancheng] Beijing Erlong Lu Hosp, Beijing Anorectal Hosp, Dept Proctol, Beijing, Peoples R China.
   [Xiong, Fang] Beijing Erlong Lu Hosp Fang Xiong, Beijing Anorectal Hosp, Dept Med Ultrason, Beijing, Peoples R China.
   [Li, Jiayan] Beijing Erlong Lu Hosp, Beijing Anorectal Hosp, Radiol Dept, Beijing, Peoples R China.
   [Qi, Shunli] Beijing Erlong Lu Hosp, Beijing Anorectal Hosp, Pathol Dept, Beijing, Peoples R China.
   [Wang, Qingbo] Beijing Erlong Lu Hosp, Beijing Anorectal Hosp, Clin Lab, Beijing, Peoples R China.
C3 Capital Medical University
RP Zhang, ZT (通讯作者)，Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China.; Zhang, ZT (通讯作者)，State Key Lab Digest Hlth, Beijing, Peoples R China.; Zhang, ZT (通讯作者)，Natl Clin Res Ctr Digest, Beijing, Peoples R China.; Liu, LC (通讯作者)，Beijing Erlong Lu Hosp, Beijing Anorectal Hosp, Dept Proctol, Beijing, Peoples R China.
EM llcell@163.com; zhangzht@ccmu.edu.cn
FU Beijing Anorectal Hospital (Beijing Erlong Lu Hospital)
FX Gratitude to all the healthcare professionals who played a crucial role
   in the treatment of Fournier's gangrene patients.
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NR 41
TC 0
Z9 0
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD OCT 15
PY 2025
VL 25
IS 1
AR 481
DI 10.1186/s12893-025-03242-8
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8RM1N
UT WOS:001595580900003
PM 41094492
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Campbell, BG
   O'Marra, SK
AF Campbell, Bonnie G.
   O'Marra, Shana K.
TI Diagnosis and surgical management of septic peritonitis in small
   animals: A review
SO VETERINARY SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; FREE PLASMA DNA; IONIZED CALCIUM-CONCENTRATION;
   SMALL-INTESTINAL BIOPSY; OPEN ABDOMINAL DRAINAGE; RETROSPECTIVE
   EVALUATION; ANASTOMOTIC LEAKAGE; RISK-FACTORS; GENERALIZED PERITONITIS;
   ENTERECTOMY SITES
AB Background Septic peritonitis (SP) is a complex disease with significant morbidity and mortality. Diagnosis can be challenging, and lack of a timely diagnosis may impact survival.Aim The aim of this review was to synthesize current knowledge on the diagnosis and surgical management of SP in dogs and cats.Conclusions Recent studies suggest refinements of previously reported clinicopathologic criteria improve diagnostic and prognostic accuracy. When evaluating blood-effusion glucose differences, clinicians should be aware of the confounding effects of point of care glucometers. Cytology specimens should be prepared immediately to avoid sample degradation. Advances in imaging have improved the relevance and diagnostic value of ultrasound and computed tomography. Surgical source control that targets the underlying cause is crucial. Accurate assessment of tissue viability may be aided by technologies under development. Anastomotic dehiscence may be reduced by using stapling devices and reinforcement with endogenous or exogenous materials. Evidence for the effectiveness of postoperative drainage via open abdomen +/- vacuum-assisted closure, or closed suction drains, is unclear. Heterogeneity of patient severity and incomplete data limit direct comparisons between studies and highlight opportunities for future investigation.Implications Developments in diagnostic and surgical techniques may improve prognostication and outcomes in septic patients. There are many opportunities for further research into diagnosis and surgical treatment of patients with septic peritonitis.
C1 [Campbell, Bonnie G.; O'Marra, Shana K.] Washington State Univ, Coll Vet Med, Dept Vet Clin Sci, Pullman, WA 99164 USA.
C3 Washington State University
RP Campbell, BG (通讯作者)，Washington State Univ, Coll Vet Med, Dept Vet Clin Sci, Pullman, WA 99164 USA.
EM bjgc@wsu.edu
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   WOOLFSON JM, 1986, VET SURG, V15, P27, DOI 10.1111/j.1532-950X.1986.tb00169.x
   Yilmaz Z, 2007, J SMALL ANIM PRACT, V48, P643, DOI 10.1111/j.1748-5827.2007.00391.x
   Zelachowski KA, 2024, VET RADIOL ULTRASOUN, V65, P429, DOI 10.1111/vru.13377
   Zhou Q, 2023, WORLD J EMERG SURG, V18, DOI 10.1186/s13017-023-00496-6
   Ziaian B, 2014, J PAK MED ASSOC, V64, P907
   Zorn CM, 2023, VET ANIM SCI, V21, DOI 10.1016/j.vas.2023.100304
NR 237
TC 2
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD JAN
PY 2026
VL 55
IS 1
BP 13
EP 31
DI 10.1111/vsu.70024
EA OCT 2025
PG 19
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CM4PJ
UT WOS:001595874700001
PM 41109949
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Smet, H
   Hirt, J
   Hahnloser, D
   Grass, F
AF Smet, Heloise
   Hirt, Jeanne
   Hahnloser, Dieter
   Grass, Fabian
TI Surgical approach to intraabdominal sepsis: a damage control approach
   can reduce stoma rates
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Staged; Damage control; Complicated diverticulitis; Two-stage
ID ACUTE DIVERTICULITIS; HARTMANNS PROCEDURE; PRIMARY ANASTOMOSIS
AB BackgroundIn patients with perforated diverticulitis and/or intraabdominal sepsis (IAS), the best surgical strategy remains controversial. While open, non-restorative Hartmann's procedure represents the procedure of choice in many centers, ostomy-sparing and minimally invasive techniques have been increasingly utilized due to short- and long-term benefits, including a reduced stoma rate. This dynamic manuscript illustrates strategic and technical considerations of the standardized institutional staged or damage control approach to IAS.TechniqueThe institutional strategy to IAS is demonstrated through an emergency procedure for perforated Hinchey IV diverticulitis in a 70-year-old woman developing an acute abdomen. After a diagnostic laparoscopy, stercoral peritonitis was confirmed and the patient underwent laparotomy. A two-stage approach (stage 1: damage control with resection of the perforated sigmoid, abdominal lavage, vacuum-assisted closure (VAC) - stage 2 (36-48 h later and during daytime): primary colorectal anastomosis and abdominal closure) was performed. While laparoscopic exploration represents the standard approach in hemodynamically stable patients, the staged procedure (resection and sepsis control) helped refine the definite strategy (goal of reconstruction and no ostomy) in a clinically improved patient during the second step. The patient recovered well during the critical therapeutic window, allowing to perform primary anastomosis and a stoma-free discharge.DiscussionClinical condition during surgery, surgeon expertise, and comorbidities are key determinants to decide whether to proceed to primary anastomosis in the case of IAS. An institutional series of our group revealed feasibility and safety of the staged approach, with 65% stoma-free patients at discharge. A standardized algorithm based on intraoperative hemodynamic parameters intends to guide surgical decision-making during staged procedures to seek optimized conditions allowing to proceed to primary anastomosis.ConclusionA staged approach according to a predefined decisional framework may help decrease the need for ostomy creation in patients with IAS.
C1 [Smet, Heloise; Hirt, Jeanne; Hahnloser, Dieter; Grass, Fabian] Univ Lausanne UNIL, Lausanne Univ Hosp CHUV, Dept Visceral Surg, Rue Bugnon 46-BH 10-222, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Grass, F (通讯作者)，Univ Lausanne UNIL, Lausanne Univ Hosp CHUV, Dept Visceral Surg, Rue Bugnon 46-BH 10-222, CH-1011 Lausanne, Switzerland.
EM fabian.grass@chuv.ch
RI Hahnloser, Dieter/J-6714-2017
OI Smet, Héloïse/0000-0001-9665-9552
FU University of Lausanne
FX Open access funding provided by University of Lausanne.
CR Antoniou SA, 2025, SURG ENDOSC, V39, P673, DOI 10.1007/s00464-024-11445-y
   Bova R, 2024, ANTIBIOTICS-BASEL, V13, DOI 10.3390/antibiotics13080776
   Cirocchi R, 2021, INT J COLORECTAL DIS, V36, P867, DOI 10.1007/s00384-020-03784-8
   Cirocchi R, 2018, TECH COLOPROCTOL, V22, P743, DOI 10.1007/s10151-018-1819-9
   Coccolini F, 2023, WORLD J EMERG SURG, V18, DOI 10.1186/s13017-023-00509-4
   Di Saverio S, 2016, SURG ENDOSC, V30, P5656, DOI 10.1007/s00464-016-4869-y
   Faes S, 2021, BJS OPEN, V5, DOI 10.1093/bjsopen/zrab106
   Giron H, 2025, SURG ENDOSC, V39, P3396, DOI 10.1007/s00464-025-11617-4
   Humes DJ, 2009, GASTROENTEROLOGY, V136, P1198, DOI 10.1053/j.gastro.2008.12.054
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   Jurt J, 2021, J CLIN MED, V10, DOI 10.3390/jcm10194524
   Komen N, 2009, INT J COLORECTAL DIS, V24, P789, DOI 10.1007/s00384-009-0692-4
   Lambrichts DPV, 2019, LANCET GASTROENTEROL, V4, P599, DOI 10.1016/S2468-1253(19)30174-8
   Oberkofler CE, 2012, ANN SURG, V256, P819, DOI 10.1097/SLA.0b013e31827324ba
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NR 23
TC 1
Z9 1
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD DEC
PY 2025
VL 39
IS 12
BP 8710
EP 8715
DI 10.1007/s00464-025-12303-1
EA OCT 2025
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA X2807
UT WOS:001596144800001
PM 41116058
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Sezikli, I
   Topcu, R
   Kendirci, M
AF Sezikli, Ismail
   Topcu, Ramazan
   Kendirci, Murat
TI Negative pressure wound therapy in high-risk gastrointestinal surgery: a
   retrospective cohort study on postoperative complications
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Negative pressure wound therapy; Traditional wound management;
   Complications; Surgery; High-risk gastrointestinal patients
ID SURGICAL SITE INFECTIONS; LAPAROTOMY; DRESSINGS
AB BackgroundSurgical site infections (SSIs) are a significant cause of morbidity in colorectal surgeries, mainly due to the contaminated nature of these procedures. Traditional wound management techniques have limitations, leading to prolonged hospital stays and increased healthcare costs. Negative pressure wound therapy (NPWT) has emerged as an advanced method for managing surgical wounds, promoting faster healing by enhancing tissue perfusion, reducing edema, and managing wound exudate. This retrospective cohort study aims to compare the outcomes of NPWT with those of conventional wound care in patients undergoing high-risk gastrointestinal surgeries.MethodsA total of 141 patients classified as having contaminated or dirty wounds were divided into two groups: the NPWT group (47 patients) and the conventional wound care group (94 patients). Postoperative outcomes, including SSIs, wound healing, dehiscence, and incisional hernia development, were monitored at 1 month and 1 year.ResultsThe results revealed a significant reduction in superficial SSIs in the NPWT group (6.4% vs. 18.1%, p = 0.04), along with shorter hospital stays (8.9 vs. 11.2 days, p = 0.01). Incisional hernia rates were also significantly lower in the NPWT group at both 1 month (6.4% vs. 12.8%, p = 0.05) and 1 year (6.4% vs. 16.0%, p = 0.03). While the reduction in deep SSIs did not reach statistical significance (2.1% vs. 9.6%, p = 0.08), the observed trend suggests further investigation.ConclusionThis study demonstrated that NPWT not only reduces the incidence of SSIs and hospital stays but also decreases the long-term incidence of incisional hernias. These findings suggest that NPWT should be considered a standard approach for managing high-risk surgical wounds, especially in gastrointestinal procedures, where infection risks are inherently greater.
C1 [Sezikli, Ismail; Topcu, Ramazan; Kendirci, Murat] Hitit Univ, Fac Med, Dept Gen Surg, TR-19030 Corum, Turkiye.
C3 Hitit University
RP Topcu, R (通讯作者)，Hitit Univ, Fac Med, Dept Gen Surg, TR-19030 Corum, Turkiye.
EM topcur58@gmail.com
RI TOPCU, RAMAZAN/GVS-3968-2022; Kendirci, Murat/KIK-6978-2024; Sezikli,
   İsmail/IXD-3740-2023
OI TOPCU, RAMAZAN/0000-0001-6214-4868; Sezikli, İsmail/0000-0002-6801-1465
CR Allegranzi Benedetta, 2016, Lancet Infect Dis, V16, pe276, DOI [10.1016/s1473-3099(16)30402-9, 10.1016/s1473-3099(16)30398-x, 10.1016/S1473-3099(16)30398-X]
   Banwell P., 2019, World J Surg, V43, P2391
   Banwell P., 2020, J Wound Care, V12, P22
   Boland PA, 2021, IRISH J MED SCI, V190, P261, DOI 10.1007/s11845-020-02283-7
   Burkhart RA, 2017, HPB, V19, P825, DOI 10.1016/j.hpb.2017.05.004
   Chadi SA., 2020, Colorectal Dis, V22, P267
   Davey MG, 2024, BJS OPEN, V8, DOI 10.1093/bjsopen/zrae081
   De Vries FEE, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004673
   Groenen H, 2023, ECLINICALMEDICINE, V62, DOI 10.1016/j.eclinm.2023.102105
   Gupta R, 2017, AM SURGEON, V83, P1166
   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
   Ingemansson R., 2017, Eur J Vasc Endovasc Surg, V53, P835
   James K, 2024, AM J SURG, V228, P70, DOI 10.1016/j.amjsurg.2023.10.031
   Javed AA, 2019, ANN SURG, V269, P1034, DOI 10.1097/SLA.0000000000003056
   Kubek EW., 2013, Microbial pathogens and strategies for combating them: Science, technology and education, P1843
   Lakhani A, 2022, SURGERY, V172, P949, DOI 10.1016/j.surg.2022.05.020
   Lynam S, 2016, INT J GYNECOL CANCER, V26, P1525, DOI 10.1097/IGC.0000000000000792
   Mark KS, 2014, SURG INNOV, V21, P345, DOI 10.1177/1553350613503736
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   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Sahebally SM, 2018, JAMA SURG, V153, DOI 10.1001/jamasurg.2018.3467
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   Scalise A, 2016, INT WOUND J, V13, P1260, DOI 10.1111/iwj.12492
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   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
NR 27
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD OCT 16
PY 2025
VL 25
IS 1
AR 739
DI 10.1186/s12876-025-04377-x
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 8SY7A
UT WOS:001596593600003
PM 41102671
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Harris, KT
   Hwang, C
   Caldwell, B
   Vemulakonda, V
   Wood, D
   Wilcox, DT
   Rove, KO
AF Harris, Kelly T.
   Hwang, Catalina
   Caldwell, Brian
   Vemulakonda, Vijaya
   Wood, Dan
   Wilcox, Duncan T.
   Rove, Kyle O.
TI Use of incisional negative pressure wound therapy in reconstructive
   pediatric and young adult urology to reduce surgical site occurrences: A
   pilot study
SO JOURNAL OF PEDIATRIC UROLOGY
LA English
DT Article
DE Patient safety; Quality improvement; Wound compli-cation; Reconstructive
   surgery; Incisional negative pressure wound therapy
ID RISK-FACTORS; INFECTION; EPIDEMIOLOGY; SURGERY
AB Background Surgical site occurrences (SSO) contribute to the morbidity and cost of postoperative complications. In adult and pediatric surgical literature, enthusiasm for incisional negative pressure wound therapy (iNPWT) on closed surgical incisions has been ongoing. Objective The aim of this pilot study is to report the early outcomes of iNPWT in reconstructive pediatric and young adult urologic surgery. Study design This is a pilot prospective cohort study at a single, tertiary care, free-standing children's hospital. Wound complication outcomes with use of iNPWT are compared to a historical cohort that underwent routine incision closures. A multivariate logistic regression model was used to predict the risk of composite SSO within the first 30 days after surgery. Results On univariate analysis, the percentage of patients experiencing SSO fell from 24.0 % to 6.9 % with introduction of iNPWT (p = 0.065). On multivariate analysis, compared to the pre-iNPWT group, placement of iNPWT was associated with a reduction in risk of composite SSO [OR 0.084 (0.009-0.415, p = 0.01]. Discussion Strengths of this study are that it was prospective in nature and there was consistency in iNPWT placement and management throughout the study period. Until more reliable biological markers of SSO risk are available, we believe that interventions to prevent SSO must be broadly applied. One limitation is that the financial and physical cost of having an iNPWT placed could not be measured for each individual patient. Conclusion In this pilot study, iNPWT was found to be a successful intervention to reduce SSO in reconstructive pediatric and young adult urology patients. Use of iNPWT could be considered for all, but perhaps particularly in those with a baseline high risk of SSO, including those with obesity or connective tissue disorders.
C1 [Harris, Kelly T.; Hwang, Catalina; Caldwell, Brian; Vemulakonda, Vijaya; Wood, Dan; Wilcox, Duncan T.; Rove, Kyle O.] Childrens Hosp Colorado, Dept Pediat Urol, Pediat Urol Res Enterprise, Aurora, CO USA.
   [Harris, Kelly T.; Hwang, Catalina; Caldwell, Brian; Vemulakonda, Vijaya; Wood, Dan; Wilcox, Duncan T.; Rove, Kyle O.] Dept Surg, Div Urol, Anschutz Med Campus, Aurora, CO USA.
C3 Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz
RP Harris, KT (通讯作者)，Childrens Hosp Colorado, Dept Pediat Urol, 13123 East 16th Ave, Aurora, CO 80054 USA.
EM kelly.harris2@childrenscolorado.org
RI /AAO-9922-2020
OI Rove, Kyle/0000-0002-2323-4139
FU Pediatric Urology Research Enterprise (PURE) , Pediatric Urology,
   Children's Hospital Colorado
FX The research was supported by the Pediatric Urology Research Enterprise
   (PURE) , Pediatric Urology, Children's Hospital Colorado.
CR Azoury SC, 2015, CHRONIC WOUND CARE M, V2, P137, DOI 10.2147/CWCMR.S62514
   Blumetti J, 2007, SURGERY, V142, P704, DOI 10.1016/j.surg.2007.05.012
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   Elghandour MM, 2024, J PEDIATR SURG OPEN, V8, DOI 10.1016/j.yjpso.2024.100153
   Elizondo RA, 2016, UROLOGY, V95, P190, DOI 10.1016/j.urology.2016.04.001
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NR 16
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1477-5131
EI 1873-4898
J9 J PEDIATR UROL
JI J. Pediatr. Urol
PD OCT
PY 2025
VL 21
IS 5
BP 1306
EP 1312
DI 10.1016/j.jpurol.2025.03.001
EA OCT 2025
PG 7
WC Pediatrics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Urology & Nephrology
GA 8UJ9D
UT WOS:001597571400014
PM 40089427
DA 2026-07-24
ER
PT J
AU Zhang, JY
   Xu, RR
   Qian, J
   Cai, XC
AF Zhang, Jianyong
   Xu, Rongrong
   Qian, Jin
   Cai, Xuchao
TI Closed incision management with negative pressure wound therapy: a
   systematic review and meta-analysis of orthopedic trauma outcomes
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Review
DE Closed incisions; Conventional dressing; Negative pressure wound
   treatment; Orthopedic trauma surgery; Surgical site infection; Wound
   dehiscence
ID SURGICAL SITE INFECTION; HIGH-RISK PATIENTS; KNEE ARTHROPLASTY; FRACTURE
   SURGERY; COMPLICATIONS; DRESSINGS; HIP; IMPACT
AB We conducted a systematic review and meta-analysis to evaluate the effectiveness of negative pressure wound therapy (NPWT ) compared to traditional wound care for closed incisions following orthopedic trauma surgery. Wound complications, including surgical site infections (SSIs) and wound dehiscence, are common in orthopedic trauma surgery, affecting a significant portion of patients. To address this, we analyzed data from 3994 participants across 15 trials, with 2045 patients receiving NPWT and 1949 receiving conventional wound dressings. Our results show that NPWT was associated with reduced deep surgical site infection (OR, 0.60; 95% CI, 0.45-0.81, P = 0.0005), superficial surgical site infection (OR, 0.34; 95% CI, 0.19-0.61, P = 0.003), and wound dehiscence (OR, 0.41; 95% CI, 0.21-0.80, P = 0.009) compared to traditional dressings. Additionally, NPWT was associated with a reduction in hospital stays (MD, 0.89; 95% CI, 0.49-1.30, P = 0.0001). However, the clinical significance of this modest reduction should be interpreted cautiously given the high heterogeneity (I-2 = 92%) observed in this outcome. Despite these positive outcomes, the study's limitations, such as the lack of long-term follow-up, the potential for publication bias, moderate to high heterogeneity in some outcomes, and the inclusion of both randomized and non-randomized studies, suggest that additional high-quality randomized controlled trials are necessary to fully validate the long-term effectiveness and safety of NPWT in this context.
C1 [Zhang, Jianyong] Hangzhou First Peoples Hosp, Hangzhou Rehabil Hosp, Xiasha Campus, Hangzhou, Peoples R China.
   [Xu, Rongrong] Qingdao No 8 Peoples Hosp, Orthoped & Sports Med Dept, Qingdao, Peoples R China.
   [Qian, Jin] WestLake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Dept Orthoped, Hangzhou, Peoples R China.
   [Cai, Xuchao] Hangzhou First Peoples Hosp, Hangzhou Geriatr Hosp, Wound Repair Dept, Chengbei Campus, Hangzhou, Peoples R China.
C3 Westlake University
RP Zhang, JY (通讯作者)，Hangzhou First Peoples Hosp, Hangzhou Rehabil Hosp, Xiasha Campus, Hangzhou, Peoples R China.; Cai, XC (通讯作者)，Hangzhou First Peoples Hosp, Hangzhou Geriatr Hosp, Wound Repair Dept, Chengbei Campus, Hangzhou, Peoples R China.
EM 154216448@qq.com; 15318731378@189.cn; qian_godspeed@163.com;
   chaoxuc@163.com
RI ; Xu, Rongrong/JXY-1470-2024
OI , Cai/0009-0005-0510-0021; 
FU Hangzhou Biopharmaceutical and Health Industry Development Support
   Technology Special Program [2024WJC186]
FX Hangzhou Biopharmaceutical and Health Industry Development Support
   Technology Special Program (2024WJC186)
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NR 32
TC 0
Z9 1
U1 2
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD OCT 23
PY 2025
VL 26
IS 1
AR 991
DI 10.1186/s12891-025-08986-1
PG 12
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA 8YR7A
UT WOS:001600488800003
PM 41131516
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Song, WJ
   Choi, HB
   Nam, H
   Lee, CY
   Choi, HJ
AF Song, Woo Jin
   Choi, Hyun Beom
   Nam, Ha Jong
   Lee, Chan Yeong
   Choi, Hwan Jun
TI Transcutaneous oxygen pressure-guided prophylactic fasciotomy and
   negative pressure wound therapy for contrast extravasation injury of the
   hand: A case report
SO MEDICINE
LA English
DT Article
DE compartment syndromes; fasciotomy; negative pressure wound therapy;
   wound healing
AB Rationale:Contrast medium extravasation injury is a rare but potentially limb-threatening complication of intravenous imaging, particularly in anatomically confined regions such as the dorsum of the hand. Thus, adjunctive diagnostic tools are needed to supplement clinical judgment and identify patients who will benefit from early surgical interventions.Patient concerns:A 55-year-old female patient presented with extensive swelling and pain in the left hand following contrast medium extravasation during a computed tomography angiography. The initial physical examination revealed minimal skin changes; however, the patient reported progressive pain and taut swelling.Diagnosis:The examination results were inconclusive of compartment syndrome. Transcutaneous oxygen pressure (TcPO2) monitoring revealed critically low perfusion values (5 mm Hg in the dorsal wrist and 1 mm Hg in the distal dorsum), suggesting evolving ischemia. Forward-looking infrared thermal imaging confirmed localized hypoperfusion.Interventions:Based on TcPO2 and thermal imaging findings, a prophylactic fasciotomy was performed. Negative pressure wound therapy was applied, and primary wound closure was performed on postoperative day 3 without the need for skin grafting.Outcomes:The patient recovered without wound-related complications, and no additional procedures were required.Lessons:This may be the first reported case of contrast medium extravasation injury in the hand managed with TcPO2-guided fasciotomy. TcPO2 and forward-looking infrared thermography may serve as alternative noninvasive tools to support early decision-making for fasciotomy in cases where traditional clinical signs are absent. Early intervention based on perfusion metrics may prevent irreversible ischemic complications.
C1 [Song, Woo Jin; Choi, Hyun Beom; Lee, Chan Yeong] Soonchunhyang Univ, Coll Med, Dept Plast & Reconstruct Surg, Seoul Hosp, Seoul, South Korea.
   [Nam, Ha Jong] Soonchunhyang Univ, Gumi Hosp, Dept Plast & Reconstruct Surg, Gumi, South Korea.
   [Choi, Hwan Jun] Soonchunhyang Univ, Cheonan Hosp, Dept Plast & Reconstruct Surg, Cheonan, South Korea.
C3 Soonchunhyang University; Soonchunhyang University; Soonchunhyang
   University
RP Choi, HJ (通讯作者)，Soonchunhyang Univ, Inst Tissue Regenerat, Coll Med, Sooncheonhyang 6 Gil 31, Cheonan Si 31151, Chungcheongnam, South Korea.; Choi, HJ (通讯作者)，Soonchunhyang Univ, Cheonan Hosp, Coll Med, Dept Plast & Reconstruct Surg, Sooncheonhyang 6 Gil 31, Cheonan Si 31151, Chungcheongnam, South Korea.
EM pswjsong@schmc.ac.kr; iprskorea@gmail.com; namssi3@naver.com;
   cksdud1627@naver.com; iprskorea@gmail.com
OI Lee, Chan Yeong/0000-0001-6494-8587; NAM, HA JONG/0000-0002-2494-0991;
   Choi, Hwanjun/0000-0002-0752-0389
FU National Research Foundation of Korea (NRF) grant - Korea government
   (MSIT) [RS-2025-00523018]; Soonchunhyang University research fund
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIT, Grant number
   RS-2025-00523018) and was supported by Soonchunhyang University research
   fund.
CR Arsenault KA, 2011, WOUND REPAIR REGEN, V19, P657, DOI 10.1111/j.1524-475X.2011.00731.x
   Behzadi AH, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010055
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NR 13
TC 0
Z9 0
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 24
PY 2025
VL 104
IS 43
AR e45413
DI 10.1097/MD.0000000000045413
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8YZ6X
UT WOS:001600698300044
PM 41137325
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Mihalache, O
   Simion, L
   Doran, H
   Bîrligea, AB
   Luca, DC
   Chitoran, E
   Bobirca, F
   Mustatea, P
   Patrascu, T
AF Mihalache, Octavian
   Simion, Laurentiu
   Doran, Horia
   Birligea, Andra Bontea
   Luca, Dan Cristian
   Chitoran, Elena
   Bobirca, Florin
   Mustatea, Petronel
   Patrascu, Traian
TI Negative Pressure Wound Therapy in the Treatment of Complicated Wounds
   of the Foot and Lower Limb in Diabetic Patients: A Retrospective Case
   Series
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE amputation; diabetic foot; gangrene; negative pressure; NPWT
ID ULCERS; MULTICENTER
AB Background: Diabetes-related foot diseases represent a global health problem because of the associated complications, the risk of amputation, and the economic burden on health systems. Negative pressure wound therapy (NPWT) is a technique that uses sub-atmospheric pressure to help promote wound healing by reducing the inflammatory exudate while keeping the wound moist, inhibiting bacterial growth, and promoting the formation of granulation tissue. Objective: This study aimed to assess the effectiveness of NPWT in preventing major amputation in diabetic patients with complicated foot or lower limb infections and to contextualize the results through a review of the existing literature. Materials and methods: We conducted a retrospective study at the First Surgical Department of "Dr. I. Cantacuzino" Clinical Hospital in Bucharest, Romania, over a 15-year period, including 30 consecutive adult patients with diabetes and soft tissue foot or lower limb infections treated with NPWT. Patients with non-diabetic ulcers, incomplete medical data, or aged under 18 were excluded. All patients underwent initial surgical debridement, minor amputation, or drainage procedures, followed by the application of NPWT using a standard protocol. Dressings were changed every 2-4 days for a total of 7-10 days. Antibiotic therapy was adapted according to the culture results. The primary outcome was limb preservation, defined as avoidance of major amputation. Secondary outcomes included in-hospital mortality and wound status at discharge. Results: NPWT was associated with a favorable outcome in 24 patients (80%), defined by wound granulation or healing without the need for major amputation. Five patients (16.6%) underwent major amputation because of failure of the primary lesion treatment, and one patient died. No statistically significant association was observed between the outcomes and standard classification scores (WIFI, IWGDF, and TPI). A comprehensive literature review helped to integrate these findings into the existing pool of knowledge. Conclusions: NPWT may support limb preservation in selected diabetic foot cases. While the retrospective design and the small sample size of the study limit generalizability, these results reinforce the need for further controlled studies to evaluate NPWT in real-life clinical settings. The correct use of NPWT combined with etiological treatment may offer a maximum chance to avoid major amputation in patients with diabetes-related foot diseases.
C1 [Mihalache, Octavian; Simion, Laurentiu; Doran, Horia; Birligea, Andra Bontea; Luca, Dan Cristian; Chitoran, Elena; Bobirca, Florin; Mustatea, Petronel; Patrascu, Traian] Carol Davila Univ Med & Pharm, Med Sch, Bucharest 050474, Romania.
   [Mihalache, Octavian; Doran, Horia; Bobirca, Florin; Mustatea, Petronel; Patrascu, Traian] Dr I Cantacuzino Clin Hosp, Surg Dept 1, Bucharest 030167, Romania.
   [Simion, Laurentiu; Luca, Dan Cristian; Chitoran, Elena] Bucharest Inst Oncol Prof Dr Alexandru Trestiorean, Gen Surg & Surg Oncol Dept 1, Bucharest 022328, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Simion, L; Doran, H (通讯作者)，Carol Davila Univ Med & Pharm, Med Sch, Bucharest 050474, Romania.; Doran, H (通讯作者)，Dr I Cantacuzino Clin Hosp, Surg Dept 1, Bucharest 030167, Romania.; Simion, L (通讯作者)，Bucharest Inst Oncol Prof Dr Alexandru Trestiorean, Gen Surg & Surg Oncol Dept 1, Bucharest 022328, Romania.
EM laurentiu.simion@umfcd.ro; horia.doran@umfcd.ro
RI DORAN, HORIA/N-9456-2013; Luca, Dan/GNP-2621-2022; Florin,
   Bobirca/GYR-2443-2022; Mihalache, Octavian/AAE-9707-2021; Simion,
   Laurențiu/R-3159-2019; Chitoran, Elena/GNP-4533-2022
OI Florin, Bobirca/0000-0002-8944-3857; Mihalache,
   Octavian/0009-0007-1887-0388; Simion, Laurențiu/0000-0002-2996-8125;
   Chitoran, Elena/0000-0001-9225-8030
FU University of Medicine and Pharmacy "Carol Davila"
FX Publication of this paper was supported by the University of Medicine
   and Pharmacy "Carol Davila", through the institutional program "Publish
   not Perish".
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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   strobe-statement, STROBE-strengthening the reporting of observational studies in epidemiology
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NR 28
TC 0
Z9 0
U1 1
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT 12
PY 2025
VL 14
IS 20
AR 7193
DI 10.3390/jcm14207193
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9AM9R
UT WOS:001601723600001
PM 41156063
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Didziokaite, G
   Kuznecovaite, A
   Sileikis, A
   Paliulyte, V
AF Didziokaite, Gabija
   Kuznecovaite, Aida
   Sileikis, Audrius
   Paliulyte, Virginija
TI Delayed Diagnosis of Acute Appendicitis in the Third Trimester of
   Pregnancy: Diagnostic Pitfalls, Multisurgical Management, and a
   Prolonged Postoperative Course-A Multidisciplinary Case Report
SO DIAGNOSTICS
LA English
DT Article
DE acute appendicitis; pregnancy; third trimester; perforated appendix;
   postoperative complications; intestinal obstruction; eventration;
   vacuum-assisted closure (VAC)
ID VACUUM-ASSISTED CLOSURE; APPENDECTOMY; THERAPY
AB Background/Objectives: Acute appendicitis is the most common non-obstetric surgical emergency during pregnancy. Diagnosing appendicitis in the third trimester remains especially challenging due to physiological changes that obscure clinical presentation and limit the utility of imaging modalities. These challenges can lead to diagnostic delays, increasing the risk of severe complications for both mother and fetus. Case presentation: We present a complex case of a 36-year-old pregnant woman at 29 + 4 weeks of gestation who developed acute appendicitis with an atypical clinical course. Her initial symptoms were nonspecific and misattributed to gastrointestinal discomfort related to pregnancy. Her condition progressively worsened, leading to an emergency laparoscopic appendectomy. Intraoperative findings confirmed a perforated, necrotic appendix. Postoperatively, she experienced multiple complications, including ileus, wound dehiscence, and complete eventration of the abdominal wall. These required two additional laparotomies and the application of vacuum-assisted closure (VAC) therapy for effective wound management. Despite the severity of maternal complications and the risk of preterm delivery, a multidisciplinary team provided coordinated care. The patient was delivered vaginally at 34 + 4 weeks using vacuum assistance. The neonate, who developed sepsis, was treated in the neonatal intensive care unit and discharged after 24 days. Both mother and child ultimately recovered. Conclusions: This case highlights the diagnostic complexity of appendicitis in late pregnancy and the potential for severe postoperative complications. Prompt surgical intervention, high clinical suspicion, and a multidisciplinary approach are crucial. Moreover, this report adds to the limited literature on the use of VAC therapy for abdominal eventration in pregnancy, demonstrating its feasibility and safety in selected cases.
C1 [Didziokaite, Gabija; Kuznecovaite, Aida; Sileikis, Audrius; Paliulyte, Virginija] Vilnius Univ, Fac Med, LT-01513 Vilnius, Lithuania.
   [Sileikis, Audrius] Vilnius Univ, Inst Clin Med, Fac Med, Clin Gastroenterol Nephro Urol & Surg, LT-01513 Vilnius, Lithuania.
C3 Vilnius University; Vilnius University
RP Didziokaite, G (通讯作者)，Vilnius Univ, Fac Med, LT-01513 Vilnius, Lithuania.
EM didziokaite.gabija@gmail.com; aida.kuznecovaite@mf.stud.vu.lt;
   audrius.sileikis@mf.vu.lt; virginija.paliulyte@mf.vu.lt
RI /Q-5839-2019; Kuznecovaitė, Aida/MAH-0574-2025; Didziokaite,
   Gabija/JCO-4454-2023; Sileikis, Auius/AAJ-1472-2020
OI Kuznecovaitė, Aida/0009-0001-6846-6670; Didziokaite,
   Gabija/0000-0002-9742-7179; Sileikis, Auius/0000-0001-9313-0581
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NR 50
TC 0
Z9 0
U1 2
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD OCT 14
PY 2025
VL 15
IS 20
AR 2593
DI 10.3390/diagnostics15202593
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9BT4V
UT WOS:001602569300001
PM 41153265
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jia, JW
   Wei, ZY
   Chen, YN
   Chen, SW
   Ma, YP
   Kang, XW
AF Jia, Jingwen
   Wei, Ziyan
   Chen, Yanan
   Chen, Shuwei
   Ma, Yingping
   Kang, Xuewen
TI A Comparative Study of the Improved Negative-Pressure Drainage Tube and
   the Penrose Silicone Drainage Tube: Which Is More Beneficial for Wounds
   from Deep Infections Healing? A Rabbit Model Study
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Model of infection; Negative-pressure wound therapy; Wound drainage
ID SOFT-TISSUE INJURY; ORTHOPEDIC-SURGERY; INSTILLATION; THERAPY; FOAM
AB Background Postoperative orthopedic wounds frequently lead to deep infections, and conventional drainage tubes exhibit inadequate drainage capacity. This study aimed to assess the efficacy of an innovative and improved negative-pressure wound irrigation drainage tube in enhancing infection control and facilitating wound healing.Methods Forty New Zealand rabbits were randomly assigned to five groups: A (control), B (abscess model), C (Penrose drain), D (improved negative-pressure wound irrigation drainage tube with drainage), and E (improved negative-pressure wound irrigation drainage tube with drainage and irrigation). A deep wound infection model was established, and its success was assessed using Gram staining and mass spectrometry. Daily weight, temperature, and drainage volume were recorded for each rabbit group. In vitro cellular experiments were performed to assess the biocompatibility of the materials. Histological examinations were conducted on postoperative day 14 to evaluate wound healing.Results Bacterial culture demonstrated the consistent presence of primary pathogenic bacteria in all groups, confirming the successful establishment of the model. Following surgery, all rabbit groups showed a consistent increase in body weight with no significant variation (P > 0.05). On day 14, the average skin temperature of Group E was significantly lower than that of the other groups (P < 0.001). The average total drainage volumes on day 14 were 9.03 +/- 0.60 ml for Group C and 10.49 +/- 0.99 ml for Group D, indicating significantly higher drainage in Group D than in Group C (P < 0.05). In vitro experiments demonstrated that the product had no adverse effect on the viability and proliferation of fibroblast cells. Histological analyses indicated that muscle tissue structure was normal in Group A, exhibited cell loss with inflammatory cell infiltration in Group B, displayed slight abnormalities with mild fibrosis in Group C, showed mild irregularities with a relatively organized arrangement of muscle cells in Group D, and remained essentially normal in Group E.Conclusion The improved negative-pressure wound irrigation drainage tube demonstrated distinct advantages over the conventional Penrose silicone drain in controlling inflammation, optimizing wound treatment, and promoting wound healing in deep wound infections.
C1 [Jia, Jingwen; Wei, Ziyan; Chen, Shuwei; Ma, Yingping; Kang, Xuewen] Lanzhou Univ, Dept Orthopaed, Hosp 2, 82 Cuiyingmen, Lanzhou 730000, Gansu, Peoples R China.
   [Chen, Yanan] Gansu Prov Hosp, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University
RP Ma, YP; Kang, XW (通讯作者)，Lanzhou Univ, Dept Orthopaed, Hosp 2, 82 Cuiyingmen, Lanzhou 730000, Gansu, Peoples R China.
EM 220220904251@lzu.edu.cn; 220220904341@lzu.edu.cn; 1523170692@qq.com;
   625694177@qq.com; 253856962@qq.com; ery_kangxw@lzu.edu.cn
RI Chen, Yanan/E-6385-2013
FU Cuiying Scientific and Technological Innovation Program of Lanzhou
   University Second Hospital; Gansu Provincial Department of Science and
   Technology, Natural Science Foundation Project, A preliminary study on
   the application of a new negative pressure triple lumen drain; Natural
   Science Foundation Project; Gansu Provincial Department of Science and
   Technology, Natural Science Foundation Project
FX The authors thank the financial support of the Cuiying Scientific and
   Technological Innovation Program of Lanzhou University Second Hospital,
   the Gansu Provincial Department of Science and Technology, Natural
   Science Foundation Project, A preliminary study on the application of a
   new negative pressure triple lumen drain in infected wounds in rabbits,
   the Gansu Provincial Department of Science and Technology, Natural
   Science Foundation Project, and the Gansu Provincial Department of
   Science and Technology, Natural Science Foundation Project.
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NR 27
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD JAN
PY 2026
VL 60
IS 1
BP 110
EP 125
DI 10.1007/s43465-025-01601-4
EA OCT 2025
PG 16
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CA6QQ
UT WOS:001602975500001
PM 41541031
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Lin, CJ
   Lin, CW
   Wu, SH
   Cheng, HM
AF Lin, Chun-Jun
   Lin, Cheng-Wei
   Wu, Szu-Hsien
   Cheng, Hao-Min
TI Effectiveness of Maggot Debridement Therapy for Chronic Wounds: A
   Systematic Review and Meta-Analysis of Randomised Controlled Trials
SO WOUND REPAIR AND REGENERATION
LA English
DT Review
DE chronic wound; debridement; maggot debridement therapy; meta-analysis;
   systemic review; wound healing
ID VENOUS LEG ULCERS; DIABETIC FOOT ULCERS; STAPHYLOCOCCUS-AUREUS; LARVAL
   THERAPY; CHYMOTRYPSIN; DEGRADATION; SECRETIONS; BIOFILMS; ETIOLOGY;
   SLOUGH
AB The research underscores an important gap in the management of chronic wounds, which frequently exhibit resistance to standard therapies. Maggot debridement therapy shows promise in removing necrotic tissue; however, data comparing its efficacy to conventional treatments is limited. We conducted a systematic review and meta-analysis of randomised controlled trials to assess the effectiveness of maggot debridement therapy versus conventional therapies, including commonly used wound care interventions such as hydrogel dressings, compression therapy, vacuum-assisted closure (VAC) therapy, sharp debridement, and so on. The population was defined as patients with chronic wounds, including venous leg ulcers, arterial ulcers, mixed arterial-venous leg ulcers, diabetic foot ulcers, and full-thickness burns. Primary outcomes assessed were the proportion of wound healing and time to wound healing, while secondary outcomes were time to wound debridement, reduction of slough, infection-free rate, eradication of Staphylococcus aureus and Pseudomonas aeruginosa, and ulcer-related pain. Ten randomised controlled trials involving 839 participants were incorporated. Maggot debridement therapy markedly decreased the duration of wound debridement compared to conventional treatment (hazard ratio: 5.16, p = 0.0006) and showed a borderline significant reduction in slough during the first week (mean difference: 17.06, p = 0.05). Maggot debridement therapy and conventional treatment did not vary in the proportion of wound healing (p = 0.17), time to wound healing (p = 0.14), infection-free rates (p = 0.10), eradication of Staphylococcus aureus (p = 0.11) and Pseudomonas aeruginosa (p = 0.46), or ulcer-related pain (p = 0.54). Maggot debridement therapy may be an effective preliminary debridement technique for wound bed preparation in chronic wounds, especially before advanced interventions such as skin grafting, and is particularly advantageous for chronic wounds unresponsive to conventional therapies. Further research is required to confirm the findings.
C1 [Lin, Chun-Jun; Lin, Cheng-Wei; Cheng, Hao-Min] Taipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan.
   [Wu, Szu-Hsien; Cheng, Hao-Min] Natl Yang Ming Chiao Tung Univ, Sch Med, Sch Med, Taipei, Taiwan.
   [Wu, Szu-Hsien] Taipei Vet Gen Hosp, Div Plast & Reconstruct Surg, Taipei, Taiwan.
   [Cheng, Hao-Min] Taipei Vet Gen Hosp, Div Evidence Based Med, Taipei, Taiwan.
   [Cheng, Hao-Min] Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Sch Med, Taipei, Taiwan.
   [Cheng, Hao-Min] Natl Yang Ming Chiao Tung Univ, Community Med Res Ctr, Sch Med, Taipei, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; Taipei Veterans General Hospital; Taipei Veterans General
   Hospital; National Yang Ming Chiao Tung University; National Yang Ming
   Chiao Tung University
RP Cheng, HM (通讯作者)，Taipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan.; Wu, SH; Cheng, HM (通讯作者)，Natl Yang Ming Chiao Tung Univ, Sch Med, Sch Med, Taipei, Taiwan.; Wu, SH (通讯作者)，Taipei Vet Gen Hosp, Div Plast & Reconstruct Surg, Taipei, Taiwan.; Cheng, HM (通讯作者)，Taipei Vet Gen Hosp, Div Evidence Based Med, Taipei, Taiwan.; Cheng, HM (通讯作者)，Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Sch Med, Taipei, Taiwan.; Cheng, HM (通讯作者)，Natl Yang Ming Chiao Tung Univ, Community Med Res Ctr, Sch Med, Taipei, Taiwan.
EM shwu3@vghtpe.gov.tw; hmcheng@vghtpe.gov.tw
RI ; Cheng, Hao-min/L-2576-2018
OI Lin, Cheng-Wei/0009-0000-4525-8804; Cheng, Hao-min/0000-0002-3885-6600;
   Lin, Chun-Jun/0009-0007-1903-5763
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NR 64
TC 1
Z9 1
U1 6
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2025
VL 33
IS 5
AR e70095
DI 10.1111/wrr.70095
PG 14
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 9DG0P
UT WOS:001603576900008
PM 41042019
DA 2026-07-24
ER
PT J
AU Kryshtalskyj, MT
   Schell, CD
   Byers, B
   Punja, KG
AF Kryshtalskyj, Michael T.
   Schell, Carson D.
   Byers, Brett
   Punja, Karim G.
TI Negative Pressure Wound Therapy: An Adjunct in Reconstructing Large
   Periocular Defects From Necrotizing Fasciitis
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Necrotizing fasciitis; negative pressure wound therapy; periocular;
   vacuum dressing
AB Purpose:To demonstrate the use of negative pressure wound therapy (NPWT) and other reconstructive techniques in the reconstruction of large tissue defects resulting from periocular necrotizing fasciitis (NF).Methods:Description of technique with 3 illustrative cases and accompanying photographic montage.Results: Technique: Debridement successfully spared post-septal tissues and the lid margin in all cases. Wounds were left open for several days until progressive infection was ruled out. NPWT was applied using hydrophobic, compressible open-pore polyurethane foam, and high-tensile polyvinyl alcohol foam to bolster the tarsorrhaphized eyelid and prevent exposure. A polyurethane, acrylic adhesive was applied overtop, and continuous vacuum at -75 mm Hg via a NPWT unit was applied for 4 to 14 days. Cases of NF included a 65-year-old woman with metastatic lung cancer, a 59-year-old man with diabetes, and a 57-year-old man with progressive preseptal cellulitis. In all cases, NPWT resulted in impressive macrodeformation and granulation of wounds, facilitating further repair using skin grafts, temporalis and orbicularis muscle flaps, and biodegradable temporizing matrix. Considering the initial extent of these wounds, all patients had excellent functional and aesthetic outcomes at 6 to 9 months, and no ophthalmic complications were observed.Conclusions:In this series, NPWT was safe and effective in facilitating complex reconstruction of large periocular tissue defects resulting from necrotizing fasciitis.
C1 [Kryshtalskyj, Michael T.; Byers, Brett; Punja, Karim G.] Univ Calgary, Cumming Sch Med, Dept Surg, Calgary, AB, Canada.
   [Schell, Carson D.] Univ Saskatchewan, Dept Ophthalmol, Saskatoon, SK, Canada.
C3 University of Calgary; University of Saskatchewan
RP Kryshtalskyj, MT (通讯作者)，5 Richard Way SW,Suite 300, Calgary, AB T3E 7M8, Canada.
EM michael.kryshtalskyj@ucalgary.ca; carsonschell@gmail.com;
   brett.byers@albertahealthservices.ca; karimpunja@hotmail.com
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NR 11
TC 0
Z9 1
U1 3
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD NOV-DEC
PY 2025
VL 36
IS 8
BP e1373
EP e1376
DI 10.1097/SCS.0000000000011935
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9DH1R
UT WOS:001603605700027
PM 40920746
DA 2026-07-24
ER
PT J
AU Boulton, AJM
   Viswanathan, V
AF Boulton, Andrew James Michael
   Viswanathan, V.
TI Evidence-based management of diabetic foot problems
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
DE Diabetic foot; Prevention; Evidence-based therapy; Oxygen-based
   therapies; Foot Infections
ID PRESSURE WOUND THERAPY; ULCERS; MULTICENTER; OSTEOMYELITIS; PREVENTION;
   AMPUTATION; RISK; ANTIBIOTICS; ULCERATION; EDUCATION
AB At present we are experiencing a rapid rise in the global prevalence of diabetes and unfortunately, this is associated with an increase in many of the late complications of diabetes, particularly diabetic foot ulcers which have a significant impairment on quality of life as well as being associated with increased morbidity and mortality. The potential for preventing first and recurrent foot ulcers is reviewed particularly related to recent developments in smart technology and remote monitoring of foot temperature and pressures under high-risk feet. Recent trials on both these areas are reviewed and show promise for the future. Pharmacological approaches to reduce the incidence of foot ulcers are then considered and the small section on the potential role of fibrates which certainly demands further investigation. With respect to treatment of complex foot ulcers, a number of recent evidence-based therapies are described including sucrose octasulfate dressings, negative pressure wound therapy and topical wound oxygen therapy. Lastly, appropriate care and management of infected DFUs is considered particularly focusing on the area of osteomyelitis. A number of excellent recent Guidelines and related reviews are then listed to help readers further understand this rapidly developing and complex area.
C1 [Boulton, Andrew James Michael] Univ Manchester, Manchester, England.
   [Boulton, Andrew James Michael] Manchester Royal Infirm, Manchester, England.
   [Viswanathan, V.] MV Hosp Diabetes, Chennai, India.
C3 University of Manchester; University of Manchester
RP Boulton, AJM (通讯作者)，Manchester Royal Infirm, Diabet Endocrinol & Metab Ctr, Peter Mt Bldg,Oxford Rd, Manchester M13 9WL, England.
EM andrew.j.boulton@manchester.ac.uk
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NR 42
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD NOV
PY 2025
VL 229
AR 112932
DI 10.1016/j.diabres.2025.112932
EA OCT 2025
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9DS8G
UT WOS:001603911900001
PM 41057113
DA 2026-07-24
ER
PT J
AU Shadid, O
   Novo, J
   Saini, R
   Seth, I
   Terrill, PJ
   Rozen, WM
AF Shadid, Omar
   Novo, Jennifer
   Saini, Raj
   Seth, Ishith
   Terrill, Patricia J.
   Rozen, Warren M.
TI Incidence of surgical site infections at skin graft recipient sites with
   negative pressure wound therapy: A meta-analysis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Negative pressure wound therapy (NPWT); Surgical site infections (SSIs);
   Graft infections; Wound healing; Postoperative infections;
   Vacuum-assisted closure (VAC)
ID VACUUM-ASSISTED CLOSURE; CONVENTIONAL DRESSING METHODS; SOFT-TISSUE
   RECONSTRUCTION; FLAP DONOR SITE; FULL-THICKNESS; MANAGEMENT; EFFICACY;
   COST; DRAINAGE; BOLSTER
AB Background Skin graft failure remains a common and challenging source of postoperative morbidity, often driven by surgical site infections. Negative pressure wound therapy (NPWT), a technique that applies controlled suction to the wound surface, has been proposed to improve graft outcomes. This systematic review assessed the efficacy of NPWT in reducing SSIs following grafting procedures. Methods A comprehensive search of the PubMed, MEDLINE, Embase, Cochrane Library, and Web of Science was performed in March 2025. Twenty-eight studies involving 2366 patients were included. The primary outcome was SSI incidence. Subgroup analyses examined NPWT type (traditional vs single-use), wound etiology and graft location. Results NPWT significantly reduced SSI rates compared to conventional dressings (5.9% vs 14.3%). Meta-analysis using a random-effects model showed a 59% reduction in the odds of infection (odds ratio [OR] = 0.41; 95% confidence interval [CI], 0.25-0.67; p < 0.001; I-2 = 41.6%). Traditional NPWT was effective (OR = 0.38; 95% CI, 0.23-0.63), while single-use NPWT was not (OR = 1.32; 95% CI, 0.19-9.27). NPWT showed significant benefit in burn wounds (OR = 0.09; 95% CI, 0.01-0.82; based on one study) and non-significant trend toward benefit in trauma wounds (OR = 0.31; 95% CI, 0.10-1.01). Lower-limb grafts demonstrated a numerical reduction in infection rates (OR = 0.55), though this was not significant. Mean graft take was approximately 7% higher in the NPWT group; however, these findings are only descriptive and were not subjected to meta-analysis. Conclusions NPWT significantly lowers SSI risk in skin grafts, particularly with traditional systems. Subgroup trends in trauma and lower-limb wounds are promising but not statistically significant and should be considered as hypothesis-generating. Single-use NPWT requires further evaluation. These findings support NPWT's broader integration into high-risk graft protocols, with device selection tailored to wound complexity and care setting.
C1 [Shadid, Omar] Univ Melbourne, Fac Med & Surg, Melbourne, Vic 3051, Australia.
   [Novo, Jennifer] Notre Dame Univ, Fac Med & Surg, Sydney, NSW 2008, Australia.
   [Saini, Raj] Simon Fraser Univ, Fac Med & Surg, Burnaby, BC V5A 1S6, Canada.
   [Seth, Ishith; Terrill, Patricia J.; Rozen, Warren M.] Monash Univ, Alfred Ctr, Peninsula Clin Sch, 99 Commercial Rd, Melbourne, Vic 3004, Australia.
   [Seth, Ishith; Terrill, Patricia J.; Rozen, Warren M.] Peninsula Hlth, Dept Plast & Reconstruct Surg, Melbourne, Vic 3199, Australia.
C3 University of Melbourne; The University of Notre Dame Australia; Simon
   Fraser University; Monash University; Peninsula Health
RP Shadid, O (通讯作者)，Univ Melbourne, Fac Med & Surg, Melbourne, Vic 3051, Australia.
EM omarshadid4@gmail.com
RI Terrill, Patricia/ABD-5014-2021; Seth, Ishith/IXX-0725-2023; Rozen,
   Warren/AAE-6296-2022
OI Terrill, Patricia/0000-0002-4971-2776; Seth, Ishith/0000-0001-5444-8925;
   Shadid, Omar/0009-0005-3471-8656; Saini, Saravraj/0009-0008-2480-7825; ,
   Jennifer/0009-0005-3919-904X; Kustos, Milan/0009-0009-1612-5274
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NR 73
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD NOV
PY 2025
VL 110
BP 306
EP 321
DI 10.1016/j.bjps.2025.08.038
EA OCT 2025
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9EP9F
UT WOS:001604518600005
PM 40967918
DA 2026-07-24
ER
PT J
AU Shields, LBE
   Chariker, M
   Sieg, EP
   Mutchnick, IS
AF Shields, Lisa B. E.
   Chariker, Mark
   Sieg, Emily P.
   Mutchnick, Ian S.
TI Vacuum-assisted closure of the scalp flap following malignant cerebral
   edema during craniotomy: pediatric case presentations and review of the
   literature
SO CHILDS NERVOUS SYSTEM
LA English
DT Article
DE Neurosurgery; Pediatric; Cerebral edema; Craniotomy; Vacuum-assisted
   closure
ID WOUND CONTROL; MANAGEMENT; THERAPY; HEAD; SYSTEM; BRAIN; SAFE
AB Intraoperative malignant cerebral edema is a rare but life-threatening complication that can arise during a traumatic decompressive craniectomy. The swelling may be significant enough to preclude skin closure. The current standard of care is to resect sufficient edematous brain tissue to close the scalp to establish an immune-competent barrier to the intracranial space. We report two pediatric patients who developed malignant edema during craniectomy that prevented skin closure. Both patients underwent placement of a temporary vacuum-assisted closure (VAC) device, facilitating resolution of the edema without sacrifice of brain tissue before scalp closure. Case #1 sustained a fall; head computed topography (CT) revealed a left subdural hematoma (SDH) and hemispheric infarct with midline shift. A craniotomy was performed during which malignant cerebral edema developed, preventing dural closure or scalp approximation. A VAC was placed which remained for 17 days, followed by successful primary closure of the scalp. Case #2 suffered multiple injuries from inflicted trauma; head CT demonstrated a large acute SDH over the left frontal and parietal region with a midline shift to the right. Emergent craniotomy was performed, and significant cranial edema was encountered to a degree for which medical intervention was not effective enough to allow skin closure. A VAC device was placed which was removed 8 days later with primary scalp closure. No infectious complications arose in either case, and no complications were attributable to the VAC devices. A temporizing VAC to protect the intracranial space when severe malignant cerebral edema occurs during a craniectomy may be preferable to tissue resection.
C1 [Shields, Lisa B. E.; Mutchnick, Ian S.] Norton Healthcare, Norton Neurosci Inst, 210 East Gray St, Suite 1102, Louisville, KY 40202 USA.
   [Chariker, Mark; Mutchnick, Ian S.] Norton Childrens Hosp, Louisville, KY 40202 USA.
   [Chariker, Mark] Kentucky Ctr Cosmet & Reconstruct Surg, Louisville, KY 40202 USA.
   [Sieg, Emily P.; Mutchnick, Ian S.] Univ Louisville, Hlth Brain & Spine Inst, Louisville, KY 40202 USA.
C3 University of Louisville
RP Mutchnick, IS (通讯作者)，Norton Healthcare, Norton Neurosci Inst, 210 East Gray St, Suite 1102, Louisville, KY 40202 USA.; Mutchnick, IS (通讯作者)，Norton Childrens Hosp, Louisville, KY 40202 USA.; Mutchnick, IS (通讯作者)，Univ Louisville, Hlth Brain & Spine Inst, Louisville, KY 40202 USA.
EM LBES@earthlink.net; drchariker@drchariker.com;
   Emily.Sieg@uoflhealth.org; ianmutchnick@gmail.com
OI Sieg, Emily/0009-0007-7945-197X
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0256-7040
EI 1433-0350
J9 CHILD NERV SYST
JI Childs Nerv. Syst.
PD OCT 30
PY 2025
VL 41
IS 1
AR 338
DI 10.1007/s00381-025-07008-8
PG 8
WC Clinical Neurology; Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pediatrics; Surgery
GA 9FD3O
UT WOS:001604873000002
PM 41165862
DA 2026-07-24
ER
PT J
AU Bahceci, T
   Aydogan, O
   Koyuncu, E
   Ergun, KE
   Kalemci, MS
AF Bahceci, Tuncer
   Aydogan, Ozan
   Koyuncu, Efekan
   Ergun, Kasim Emre
   Kalemci, Mustafa Serdar
TI Wound Management Practices in Scrotal-Confined Fournier's Gangrene
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Fournier gangrene; Wound care; Vacuum-assisted closure; Conventional
   dressing; Length of hospitalisation
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE
AB Objective: To compare real-world outcomes of different wound care strategies following surgical debridement in scrotal-confined Fournier Gangrene (FG), without inferring causality. Study Design: Observational study. Place and Duration of the Study: Department of Urology, Aydin Adnan Menderes University, and Ege University, Izmir, Turkiye, from August 2013 to October 2023. Methodology: Eighty-six patients with scrotal-confined FG were included. They were divided into three postoperative wound care groups: Group 1 used gauze impregnated with rifampicin and nitrofurantoin, Group 2 used rivanol-impregnated gauze, and Group 3 used vacuum-assisted closure (VAC). Data on demographics, microbial profiles, antibiotic use, and clinical outcomes (including hospital stay) were recorded. Group comparisons were performed using one-way ANOVA, Kruskal-Wallis, or Chi-square tests as appropriate. Results: The patients' age ranged from 26 to 96 years (mean 63.9 years). The most common single morbidity was diabetes (29.1%). Predominant pathogens were polymicrobial (24.4%) and E. coli (23.3%) in isolation. Overall mortality was 5.8%. Median hospital stays were 9 days (range: 5-28) in Group 1, compared to 14 days (6-40) and 15 days (6-31) in Groups 2 and 3, respectively (p <0.001), with Group 1 being significantly shorter. Secondary debridement rates were similar across groups: 12.5% in Group 1, 37.5% in Group 2, 50% in Group 3 (p = 0.32). Antibiotic choices differed significantly among the groups (p <0.001). Notably, the triple combination regimen of daptomycin, tigecycline, and meropenem was not used in Group 1. Conclusion: Topical antibiotic dressing using mesh dressings impregnated with rifampicin and nitrofurantoin was associated with a shorter hospitalisation compared to rivanol and VAC therapy in scrotal-confined FG. These findings suggest that rifampicin and nitrofurantoin-based topical therapy may be viable alternatives in resource-limited settings, or where VAC is unavailable.
C1 [Bahceci, Tuncer; Aydogan, Ozan] Aydin Adnan Menderes Univ, Dept Urol, Aydin, Turkiye.
   [Koyuncu, Efekan; Ergun, Kasim Emre; Kalemci, Mustafa Serdar] Ege Univ, Dept Urol, Izmir, Turkiye.
C3 Adnan Menderes University; Ege University
RP Bahceci, T (通讯作者)，Aydin Adnan Menderes Univ, Dept Urol, Aydin, Turkiye.
EM tuncerbahceci@adu.edu.tr
RI bahceci, tuncer/LWK-0430-2024; /ABH-2146-2021; ergün, kasım
   emre/DLK-3027-2022
OI Aydoğan, Ozan/0009-0003-9424-7492
CR Altunoluk Bulent, 2012, ISRN Urol, V2012, P762340, DOI 10.5402/2012/762340
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NR 24
TC 0
Z9 0
U1 3
U2 8
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD AUG
PY 2025
VL 35
IS 8
BP 981
EP 986
DI 10.29271/jcpsp.2025.08.981
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9HG6S
UT WOS:001606320200008
PM 40843563
OA gold
DA 2026-07-24
ER
PT J
AU Li, SQ
   Guan, XF
   Huang, XR
   Wang, Z
   Mo, LJ
   Xie, MY
   Liu, YX
   Luo, WX
AF Li, Siqing
   Guan, Xiaofang
   Huang, Xirong
   Wang, Zhong
   Mo, Linjie
   Xie, Minyi
   Liu, Yuxia
   Luo, Wenxin
TI Negative pressure wound therapy for preventing wound complications
   following stoma reversal: A systematic review and meta-analysis of
   randomized controlled trials
SO ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
LA English
DT Review
DE Wound complications; Negative pressure wound therapy; Stoma reversal;
   Meta-analysis; Surgical site infections
ID SURGICAL SITE INFECTION; CLOSURE
AB Objective: To evaluate the effectiveness of negative pressure wound therapy in preventing wound complications following colorectal stoma reversal and provide evidence-based recommendations for its clinical application. Methods: A comprehensive search was conducted across five English databases (PubMed, Embase, Web of Science, Cochrane Library, Scopus) and three Chinese databases (Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang) from their inception to December 2024. Grey literature and trial registries were also included. Eligible studies were randomized controlled trials investigating negative pressure wound therapy for patients undergoing stoma reversal. Primary outcomes included wound complications (surgical site infections, hematoma, seroma); secondary outcomes comprised hospital stay, wound healing duration, and dressing costs. Results: Eight randomized trials involving 517 patients were included. Negative pressure wound therapy significantly reduced wound complications (odds ratio, 0.50; 95% confidence interval, 0.27-0.94), shortened wound healing time (mean difference, -4.31; 95% confidence interval, -4.97 to -3.65), and decreased hospital stay (mean difference, -1.05; 95% confidence interval, -1.70 to -0.41). Subgroup analysis demonstrated benefits in the linear closure group (odds ratio, 0.11; 95% confidence interval, 0.02-0.49) but not in the pursestring closure groups. No significant differences were observed in surgical site infections, hematoma, seroma, or dressing costs. Conclusions: Negative pressure wound therapy reduces wound complications, accelerates wound healing, and shortens hospital stays after stoma reversal. Standardized protocols and additional high-quality trials are required to establish negative pressure wound therapy as a routine practice. Systematic review registration: Prospectively registered in PROSPERO (ID CRD42023451001).
C1 [Li, Siqing; Guan, Xiaofang; Huang, Xirong; Mo, Linjie; Liu, Yuxia; Luo, Wenxin] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Gastrointestinal Surg, Zhuhai, Peoples R China.
   [Wang, Zhong] Shenzhen Futian Dist Matern & Child Healthcare Hos, Nursing Dept, Shenzhen, Peoples R China.
   [Xie, Minyi] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Gen Surg, Zhuhai, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Liu, YX; Luo, WX (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 5, Dept Gastrointestinal Surg, Zhuhai, Peoples R China.
EM liuyuxia@mail.sysu.edu.cn; luort@mail.sysu.edu.cn
FU Social Development Program of the Zhuhai Science and Technology Bureau
   [2320004000239, 2320004000209]
FX Funding This study was supported by the Social Development
   Program of the Zhuhai Science and Technology Bureau (Grant No.
   2320004000239 and 2320004000209) . The funders had no role in
   considering the study design or in the collection, analysis,
   interpretation of data, writing of the report, or decision to submit the
   article for publication.
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NR 39
TC 1
Z9 1
U1 2
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2347-5625
EI 2349-6673
J9 ASIA-PAC J ONCOL NUR
JI Asia-Pac. J. Oncol. Nurs.
PD DEC
PY 2025
VL 12
AR 100778
DI 10.1016/j.apjon.2025.100778
EA DEC 2025
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 9HJ1D
UT WOS:001606385000003
PM 41210318
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Srivastava, AK
   Kummer, KA
   Troop, BR
   Gildehaus, AJ
   Gunn, K
   Davis, G
AF Srivastava, Anil K.
   Kummer, Katherine A.
   Troop, Bryan R.
   Gildehaus, Alison J.
   Gunn, Kulsoom
   Davis, Gina
TI Bio-resorbable poly-4-hydroxybutyrate (P4HB) mesh for abdominal wall
   reconstruction is effective in high-risk patients and contaminated
   abdomen
SO HERNIA
LA English
DT Article
DE Poly-4-hydroxybutyrate mesh; Abdominal wall reconstruction; High-risk
   comorbidities; Contaminated abdomen
ID VENTRAL HERNIA REPAIR; LONG-TERM; SYNTHETIC MESH; BIOLOGIC MESH;
   COMPLICATIONS; MULTICENTER; RECURRENCE; OUTCOMES; COHORT
AB PurposeAbdominal wall reconstruction in patients with high-risk comorbidities and contamination is controversial. There is no standardized mesh choice for such clinical circumstances. We reviewed our experience of poly-4-hydroxybutyrate (P4HB) mesh for abdominal wall reconstruction in hostile abdomen after emergency and elective abdominal surgeries.MethodsWe performed a retrospective review of 48 patients with CDC class 3 or 4 contamination and high-risk comorbidities who underwent abdominal wall reconstruction with P4HB between June 2016-October 2019. Data collected included demographics, abdominal closure techniques, and long-term surgical site complications and hernia recurrence.ResultsPatients ranged from 33-88 years old; 70% were female. BMI ranged from 14-70 kg/m2 (mean 36, SD +/- 11.31). High-risk comorbidities were present in 75% of patients. Emergency abdominal closures were performed in 69% of patients. Underlay Phasix (TM) ST mesh was used in 71% of emergency and 53% of elective abdominal closures. Myofascial release was required in 21% of elective and 9% of emergency patients. Fascial negative pressure wound therapy was used in 45% of emergency and 20% of elective patients. Surgical site occurrences were seen in 42% of emergency and 53% of elective abdominal closures. At a mean follow-up of 41.8 months, hernias had recurred in 16% patients after emergency and 20% after elective procedures.ConclusionP4HB mesh is well tolerated and provides durable abdominal wall reconstruction with acceptable hernia recurrence after emergency and elective abdominal closure, making it a sensible option for abdominal closure in high-risk comorbidities and abdominal contamination.
C1 [Srivastava, Anil K.; Kummer, Katherine A.; Troop, Bryan R.; Gildehaus, Alison J.; Gunn, Kulsoom; Davis, Gina] Mercy Hosp, Dept Surg, Div Trauma & Acute Care Surg, 621 S New Ballas Rd, St Louis, MO 63141 USA.
C3 Saint Johns Mercy Medical Center
RP Srivastava, AK (通讯作者)，Mercy Hosp, Dept Surg, Div Trauma & Acute Care Surg, 621 S New Ballas Rd, St Louis, MO 63141 USA.
EM anil.srivastava@mercy.net
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NR 38
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD OCT 31
PY 2025
VL 30
IS 1
AR 2
DI 10.1007/s10029-025-03497-3
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9IB8F
UT WOS:001606876000003
PM 41171463
DA 2026-07-24
ER
PT J
AU Toz, H
   Kuserli, Y
   Türkyilmaz, G
   Kavala, AA
   Türkyilmaz, S
AF Toz, Hasan
   Kuserli, Yusuf
   Turkyilmaz, Gulsum
   Kavala, Ali Aycan
   Turkyilmaz, Saygin
TI Comparison of treatment approaches for mediastinitis after coronary
   artery bypass grafting: Negative pressure wound therapy versus
   conventional methods
SO TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND
   CARDIOVASCULAR SURGERY
LA Turkish
DT Article
DE Coronary artery bypass grafting; mediastinitis; negative-pressure wound
   therapy; postoperative complications; wound healing
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   POSTOPERATIVE MEDIASTINITIS; STERNOTOMY; INFECTION; RECONSTRUCTION;
   UNIVERSITY; DRAINAGE; SAFETY
AB Background: This study aims to compare the effectiveness of negative-pressure wound therapy (NPWT) compared to conventional methods for the treatment of mediastinitis following coronary artery bypass grafting. Methods: Between January 2010 and January 2023, a total of 87 patients (47 males, 40 females; mean age: 62.0 +/- 10.2 years; range, 35 to 80 years) who developed mediastinitis following sternotomy were retrospectively analyzed. The patients were divided into two groups: those treated with conventional methods (n=39) from January 2010 to February 2015 and those treated with NPWT (n=48) from March 2015 to January 2023. Clinical outcomes, including treatment duration, infection resolution time, hospital stay, and mortality rate, were recorded. Results: The NPWT group had significantly shorter treatment durations (20.1 +/- 4.0 days) than the conventional group (58.6 +/- 17.1 days, p<0.001). The time to achieve negative cultures was also significantly reduced in the NPWT group (15.3 +/- 3.6 days) compared to the conventional group (36.7 +/- 8.1 days, p<0.001). The length of hospital stay was shorter in the NPWT group (34.3 +/- 12.8 days) compared to the conventional group (88.0 +/- 21.1 days, p<0.001). The NPWT group had a lower hospital mortality rate (4.2%) than the conventional group (17.9%, p=0.049). Conclusion: The NPWT demonstrated superior efficacy in managing postoperative mediastinitis compared to conventional methods, highlighting its potential as a preferred treatment option for this serious complication.
C1 [Toz, Hasan; Kuserli, Yusuf; Turkyilmaz, Gulsum; Kavala, Ali Aycan; Turkyilmaz, Saygin] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Cardiovasc Surg, Istanbul, Turkiye.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital
RP Toz, H (通讯作者)，Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Cardiovasc Surg, Istanbul, Turkiye.
EM tozhasan@hotmail.com
RI /AAO-8346-2021; Kavala, Ali Aycan/KEI-8579-2024; TÜRKYILMAZ,
   SAYGIN/AGT-8514-2022
OI Toz, Hasan/0000-0002-4228-6233; Kavala, Ali Aycan/0000-0001-6881-4439;
   TÜRKYILMAZ, SAYGIN/0000-0003-2165-6853
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   Liu YT, 2024, INT J SURG, V110, P8107, DOI 10.1097/JS9.0000000000002138
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NR 28
TC 1
Z9 1
U1 0
U2 1
PU BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
PI ATASEHIR
PA ORNEK MH DR SUPHI EZGI SK SARAY APT NO 11 D 6, ATASEHIR, ISTANBUL 34704,
   Turkiye
SN 1301-5680
J9 TURK GOGUS KALP DAMA
JI Turk Gogus Kalp Damar Cerrahisi Derg.
PD OCT
PY 2025
VL 33
IS 4
BP 412
EP 422
DI 10.5606/tgkdc.dergisi.2025.28035
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9JL4T
UT WOS:001607812900004
PM 41510548
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Fenske, J
   Kreiker, H
   Lampert, P
   Steffen, C
   Koerdt, S
   Nahles, S
   Kreutzer, K
   Heiland, M
   Rendenbach, C
   Neckel, N
AF Fenske, Jakob
   Kreiker, Henri
   Lampert, Philipp
   Steffen, Claudius
   Koerdt, Steffen
   Nahles, Susanne
   Kreutzer, Kilian
   Heiland, Max
   Rendenbach, Carsten
   Neckel, Norbert
TI Donor Site Morbidity in Fibula Free Flaps: A Technique-Dependent
   Comparative Analysis of Donor Site Wound Healing
SO MICROSURGERY
LA English
DT Article
DE donor site closure; fibula free flap; negative pressure wound therapy;
   primary closure; skin graft; two-stage closure
ID SKIN-GRAFTS; CLOSURE; MANAGEMENT; THERAPY
AB Background The fibula free flap (FFF) is a mainstay in maxillofacial reconstruction, yet donor site morbidity remains a significant clinical concern. Closure technique is a key factor influencing complication rates, but comparative data remain heterogeneous. This study provides a technique-dependent analysis of 60-day donor site wound healing in FFF with skin paddles and reports a two-stage closure approach.Methods A retrospective review of 211 patients undergoing FFF between 2017 and 2024 was conducted. Donor site complications within the first 60 postoperative days were assessed and stratified by closure technique: one-stage split-thickness skin grafting (STSG) with or without negative pressure wound therapy (NPWT), and a two-stage closure consisting of one-week NPWT followed by STSG. Multivariate logistic regression was applied to identify independent predictors for complications.Results Overall, 50.2% of patients experienced donor site complications, with wound healing disorders (31.8%) and (partial) skin necrosis (23.7%) most prevalent. Regarding wound closure, STSG coverage without NPWT was associated with the highest morbidity and a complication rate of 91.0%. Despite being limited in sample size, the two-stage closure, despite larger skin defects, showed complication rates comparable to one-stage closure with NPWT. Multivariate analysis identified STSG with NPWT (OR 0.1 [0.01; 0.4], p = 0.002) and two-stage closure (OR 0.1 [0.01; 0.5], p = 0.01) as protective factors for wound healing complications.Conclusion Donor site morbidity following FFF harvest with skin paddles is significantly impacted by closure technique. Wound management using one- or two-stage STSG with NPWT is preferred. Initial results of the two-stage closure indicate potentially beneficial outcomes for extensive defects and warrant further prospective validation.
C1 [Fenske, Jakob] Charite Univ Med Berlin, Dept Oral & Maxillofacial Surg, Berlin, Germany.
   Free Univ Berlin, Berlin, Germany.
   Humboldt Univ, Berlin, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Free University of Berlin; Humboldt
   University of Berlin
RP Fenske, J (通讯作者)，Charite Univ Med Berlin, Dept Oral & Maxillofacial Surg, Berlin, Germany.
EM jakob.fenske@charite.de
RI ; Steffen, Claudius/AAS-6626-2021; Fenske, Jakob/LLM-2561-2024;
   Rendenbach, Carsten/E-8384-2013; Heiland, Max/IUM-8981-2023; Nahles,
   Susanne/C-1327-2019
OI Kreiker, Henri/0000-0003-1935-3546; Kreutzer,
   Kilian/0000-0003-0581-4137; Steffen, Claudius/0000-0003-4221-4878;
   Fenske, Jakob/0009-0000-3453-3903; Rendenbach,
   Carsten/0000-0002-9565-7640; Heiland, Max/0000-0002-4987-2913; Koerdt,
   Steffen/0000-0002-8679-8775; Nahles, Susanne/0000-0001-8522-0763
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
CR Akashi M, 2016, ORAL MAXILLOFAC SURG, V20, P233, DOI 10.1007/s10006-016-0556-3
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   Rendenbach C, 2016, J CRANIO MAXILL SURG, V44, P155, DOI 10.1016/j.jcms.2015.10.027
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   Wang YY, 2016, J ORAL MAXIL SURG, V74, P200, DOI 10.1016/j.joms.2015.08.015
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NR 25
TC 0
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD NOV 5
PY 2025
VL 45
IS 8
AR e70139
DI 10.1002/micr.70139
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9JN0O
UT WOS:001607854500001
PM 41190704
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Fukasawa, T
   Imaizumi, K
   Terashima, K
   Kasajima, H
   Furukawa, N
   Ito, K
   Odagiri, T
   Yamana, D
   Tsuruga, Y
   Umehara, M
   Kurushima, M
   Nakanishi, K
AF Fukasawa, Takumu
   Imaizumi, Ken
   Terashima, Kazutoshi
   Kasajima, Hiroyuki
   Furukawa, Naoe
   Ito, Keiichiro
   Odagiri, Tadashi
   Yamana, Daisuke
   Tsuruga, Yosuke
   Umehara, Minoru
   Kurushima, Michihiro
   Nakanishi, Kazuaki
TI Delayed Primary Skin Closure Followed by Single-use Negative-pressure
   Wound Therapy Is Optimal for Wound Management After Bowel-stoma Reversal
SO IN VIVO
LA English
DT Article
DE Stoma closure; surgical site infection; negative-pressure wound therapy;
   delayed primary closure
ID COMPLICATIONS; INFECTION; MORTALITY; LOOP
AB <bold>Background/Aim:</bold> Although the purse-string suture (PSS) method is widely adopted to reduce surgical-site infection (SSI; the commonest complication following bowel-stoma closure), this technique is associated with delayed epithelialization. Recently, delayed primary closure (DPC) combined with negative-pressure wound therapy (NPWT) has been proposed as a promising alternative. This study aimed to evaluate the clinical efficacy of DPC with NPWT compared to the PSS method in stoma-closure surgery. <bold>Patients and Methods:</bold> We conducted a retrospective observational study involving 31 patients who underwent stoma closure between January 2021 and March 2023. Patients were categorized into two groups: PSS with or without NPWT (PSS +/- NPWT; n=15) and DPC with NPWT (DPC+NPWT; n=16). The primary outcome was wound-healing duration; the secondary outcomes were patient satisfaction and in-hospital costs. <bold>Results:</bold> The wound-healing duration was significantly shorter in the DPC+NPWT group compared to the PSS +/- NPWT group (median: 20 vs. 45 days, p<0.001). Multivariate analysis identified wound-closure method as an independent predictor of wound healing at 30 days. Patient-reported outcomes indicated improved wound-care experience and a trend toward better cosmetic satisfaction in the DPC+NPWT group. Although not statistically significant, the total in-hospital costs were lower in the DPC+NPWT group despite higher device-related expenditures. <bold>Conclusion:</bold> DPC with NPWT significantly shortened the wound-healing duration and showed potential benefits regarding patient satisfaction and healthcare costs compared to the PSS method. These findings suggest DPC with NPWT as a viable alternative for bowel-stoma closure and wound management.
C1 [Fukasawa, Takumu; Imaizumi, Ken; Kasajima, Hiroyuki; Ito, Keiichiro; Odagiri, Tadashi; Yamana, Daisuke; Tsuruga, Yosuke; Umehara, Minoru; Kurushima, Michihiro; Nakanishi, Kazuaki] Hakodate Municipal Hosp, Dept Gastroenterol Surg, 1-10-1 Minatocho, Hakodate, Hokkaido 0418680, Japan.
   [Terashima, Kazutoshi; Furukawa, Naoe] Hakodate Municipal Hosp, Dept Wound Ostomy & Continence Nurse, Hakodate, Hokkaido, Japan.
RP Imaizumi, K (通讯作者)，Hakodate Municipal Hosp, Dept Gastroenterol Surg, 1-10-1 Minatocho, Hakodate, Hokkaido 0418680, Japan.
EM imaken1983@gmail.com
RI Imaizumi, Ken/ABW-2302-2022
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NR 25
TC 1
Z9 1
U1 0
U2 1
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD NOV-DEC
PY 2025
VL 39
IS 6
BP 3418
EP 3427
DI 10.21873/invivo.14139
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 9KB6N
UT WOS:001608235100030
PM 41167677
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lu, RN
   Wang, H
   Zhang, LJ
   Wu, J
   Liu, J
AF Lu, Ruonan
   Wang, Hui
   Zhang, Lijuan
   Wu, Jian
   Liu, Jun
TI Systemic sclerosis complicated by skin ulcers: A case report and
   literature review
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Systemic sclerosis; skin ulcer; infection; interleukin-6; ozone therapy
ID OZONE; METAANALYSIS
AB This article reports the diagnosis and treatment of a 50-year-old female patient with systemic sclerosis complicated by a nonhealing wound on her left hand. Following comprehensive treatments including debridement, vacuum sealing drainage, ozone therapy, skin grafting, and phalangeal fusion, the wound healed successfully. This article highlights the potentially contradictory role of interleukin-6 inhibitors in the treatment of patients with systemic sclerosis and ulcers as well as emphasizes the application value of ozone therapy in improving tissue hypoxia and promoting healing.
C1 [Lu, Ruonan; Wang, Hui; Wu, Jian; Liu, Jun] Gansu Prov Hosp, Dept Burns, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
   [Zhang, Lijuan] Gansu Prov Hosp, Dept Blood Transfus, Lanzhou, Gansu, Peoples R China.
RP Liu, J (通讯作者)，Gansu Prov Hosp, Dept Burns, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
EM 13659329321@163.com
FU Lanzhou Science and Technology Bureau [No. 2023-2-99]
FX This work was financially supported by the Lanzhou Science and
   Technology Bureau (No. 2023-2-99) and Clinical Medical Research Center
   for Burns and Wound Repair in Gansu Province (No. 21JR7RA674).
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NR 24
TC 0
Z9 0
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD NOV
PY 2025
VL 53
IS 11
AR 03000605251391945
DI 10.1177/03000605251391945
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 9ML4F
UT WOS:001609854500001
PM 41198585
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rajabaleyan, P
   Kaalby, L
   Deding, U
   al-Najami, I
   Ellebæk, MB
AF Rajabaleyan, Pooya
   Kaalby, Lasse
   Deding, Ulrik
   al-Najami, Issam
   Ellebaek, Mark Bremholm
TI Mortality in patients with secondary peritonitis treated by primary
   closure or vacuum-assisted closure: nationwide register-based cohort
   study
SO BJS OPEN
LA English
DT Article
DE open abdomen; primary abdominal closure
ID TEMPORARY ABDOMINAL CLOSURE; EMERGENCY GENERAL-SURGERY; PRESSURE WOUND
   THERAPY; OPEN ABDOMEN TREATMENT; PLANNED RELAPAROTOMY; INTRAABDOMINAL
   INFECTIONS; SEPTIC PATIENTS; ON-DEMAND; SEPSIS; WSES
AB Background Secondary peritonitis caused by gastrointestinal perforation is associated with significant morbidity and mortality. Effective management includes surgical source control, antibiotic therapy, and intensive resuscitation. The choice between primary abdominal closure (PAC) and vacuum-assisted closure (VAC) in the management of secondary peritonitis remains a subject of debate.Methods This Danish nationwide register-based cohort study included patients undergoing emergency surgery for secondary peritonitis from perforation of the small intestine, colon, or rectum between 2007 and 2021 who were treated with either PAC or VAC. Data were extracted from national registries, including the Danish Register of Cause of Death and the Danish National Patient Registry. The primary outcome was overall all-cause mortality; secondary outcomes were all-cause mortality at 30 days, 90 days, and 1 year.Results In all, 13 898 patients were included (1017 in the VAC group, 12 881 in the PAC group). VAC-treated patients had significantly higher Charlson Co-morbidity Index scores and were slightly younger. In the subgroup with available laboratory data, VAC-treated patients also presented with more severe biochemical derangements, including elevated C-reactive protein, leukocytes, bilirubin, and lactate, as well as lower haemoglobin, suggesting a higher baseline severity of illness. The overall risk-stratified mortality rate (RSMR) was 49.1% for VAC and 52.0% for PAC (P = 0.222). The 30-day mortality rate was 16.9% in both the VAC and PAC groups, with RSMR of 17.4% and 18.3%, respectively (P = 0.656). At 90 days, mortality was 24.3% and 22.5% in the VAC and PAC groups, respectively, with a corresponding RSMR of 23.2% and 24.2% (P = 0.437). One year after surgery, the mortality rate was 31.3% for VAC and 29.5% for PAC, with a corresponding RSMR of 30.3% and 31.6% (P = 0.346).Conclusion This nationwide cohort study revealed no significant differences in mortality between PAC and VAC in patients with secondary peritonitis at any of the designated time points. Demographic and laboratory data suggest that VAC-treated patients had a higher baseline severity of illness.
   This nationwide Danish register-based cohort study compared mortality outcomes in 13 898 patients undergoing surgery for secondary peritonitis between primary abdominal closure (PAC) and vacuum-assisted closure (VAC). No significant differences were found in overall or time-specific (30-day, 90-day, and 1-year) mortality between the two groups. These findings suggest that PAC and VAC are comparable in terms of mortality outcomes in the management of secondary peritonitis.
C1 [Rajabaleyan, Pooya; Kaalby, Lasse; Deding, Ulrik; al-Najami, Issam; Ellebaek, Mark Bremholm] Odense Univ Hosp, Res Unit Surg, JB Winslows Vej 4, DK-5000 Odense, Denmark.
   [Rajabaleyan, Pooya; Kaalby, Lasse; Deding, Ulrik; al-Najami, Issam; Ellebaek, Mark Bremholm] Univ Southern Denmark, Fac Hlth Sci, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark
RP Rajabaleyan, P (通讯作者)，Odense Univ Hosp, Res Unit Surg, JB Winslows Vej 4, DK-5000 Odense, Denmark.
EM Pooya.Rajabaleyan@skane.se
RI Kaalby, Lasse/AGN-4657-2022; Deding, Ulrik/AAE-2844-2019; Ellebaek, Mark
   Bremholm/ADW-1803-2022
OI Kaalby, Lasse/0000-0002-6721-3604; Rajabaleyan,
   Pooya/0000-0002-6882-9427; Deding, Ulrik/0000-0002-8263-2989; Ellebaek,
   Mark Bremholm/0000-0001-6550-7505
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   Kirkpatrick AW, 2015, ANN SURG, V262, P38, DOI 10.1097/SLA.0000000000001095
   Kubiak BD, 2010, SHOCK, V34, P525, DOI 10.1097/SHK.0b013e3181e14cd2
   Kunitatsu K, 2023, ANN MED SURG, V85, P645, DOI 10.1097/MS9.0000000000000334
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   Müller V, 2020, ACTA CHIR BELG, V120, P179, DOI 10.1080/00015458.2019.1576448
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NR 70
TC 0
Z9 1
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD DEC
PY 2025
VL 9
IS 6
AR zraf118
DI 10.1093/bjsopen/zraf118
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9OW4C
UT WOS:001611504500001
PM 41219129
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Medina-Valarezo, D
   Gallardo-Arrieta, F
   Paredes-Carvajal, P
   Camacho-Pazmiño, M
AF Medina-Valarezo, Diego
   Gallardo-Arrieta, Fanny
   Paredes-Carvajal, Pamela
   Camacho-Pazmino, Martha
TI Negative pressure assisted by vacuum closure as an adjuvant to te graft
   for the treatment of complex wounds in a domestic dog. CASE REPORT.
SO REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS
LA Spanish
DT Article
DE Graft; negativepressure; VAC; veterinary wounds; wounds in dogs
ID THICKNESS SKIN-GRAFTS; THERAPY
AB The treatment of wounds in veterinary patients continues to be a major challenge. Innovations in medical technology have enabled the adoption of advanced techniques that enhance the wound healing process and reduce overall recovery time. This case report presents the application of vacuum-assisted closure negative pressure therapy to support a skin graft in a canine patient. This approach uses a porous open-cell foam placed on the wound bed, sealed with adhesive transparent film and connected to a programmable device that generates subatmospheric pressure ranging from 50 to 200 mmHg. The setup creates a sealed and anaerobic environment, facilitating wound management. In this case, a chronic non-healing wound was treated with a scrotal skin autograft from the same animal. The integration of the graft into the lesion bed was enhanced through negative pressure application, achieving full adherence within 10 hours. These findings support the effectiveness of application of vacuum-assisted closure therapy in veterinary skin graft procedures.
C1 [Medina-Valarezo, Diego; Camacho-Pazmino, Martha] Hosp Vet Planeta Vida, Latacunga, Ecuador.
   [Medina-Valarezo, Diego; Gallardo-Arrieta, Fanny] Univ Zulia, Fac Ciencias Vet Maracaibo, Zulia, Venezuela.
   [Medina-Valarezo, Diego; Paredes-Carvajal, Pamela] Uiversidad Reg Autonoma Andes, UNIANDES, Quevedo, Ecuador.
C3 Universidad Regional Autonoma de los Andes (UNIANDES)
RP Medina-Valarezo, D (通讯作者)，Hosp Vet Planeta Vida, Latacunga, Ecuador.; Medina-Valarezo, D (通讯作者)，Univ Zulia, Fac Ciencias Vet Maracaibo, Zulia, Venezuela.; Medina-Valarezo, D (通讯作者)，Uiversidad Reg Autonoma Andes, UNIANDES, Quevedo, Ecuador.
EM diego_xavier_mv@hotmail.com
CR Becker ST, 2010, INT J ORAL MAX SURG, V39, P699, DOI 10.1016/j.ijom.2010.03.016
   Depoortère C, 2020, EMC - Cirugía Plástica Reparadora y Estética, V28, P1, DOI 10.1016/s1634-2143(20)43810-5
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NR 14
TC 0
Z9 0
U1 0
U2 2
PU UNIV ZULIA, FACULTAD CIENCIAS VETERINARIAS
PI MARACAIBO
PA UNIVERSIDAD DEL ZULIA, MARACAIBO, VENEZUELA
SN 0798-2259
J9 REV CIENT-FAC CIEN V
JI Rev. Cient.-Fac. Cienc. Vet.
PY 2025
VL 35
IS 3
AR 5
DI 10.52973/rcfcv-e35661
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 9QA8W
UT WOS:001612305000009
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ciuntu, BM
   Zamfir, AS
   Maxim, M
   Zamfir, CL
   Ciuntu, RE
   Zabara, ML
   Abdulan, IM
   Corlade-Andrei, M
   Timofte, DV
   Balan, GG
AF Ciuntu, Bogdan Mihnea
   Zamfir, Alexandra-Simona
   Maxim, Madalina
   Zamfir, Carmen Lacramioara
   Ciuntu, Roxana Elena
   Zabara, Mihai Lucian
   Abdulan, Irina Mihaela
   Corlade-Andrei, Mihaela
   Timofte, Daniel Vasile
   Balan, Gheorghe G.
TI Management of Gastric Fistulas After Gastric Sleeve Using E-VAC Therapy
SO DIAGNOSTICS
LA English
DT Article
DE gastric fistula; endoluminal vacuum assisted closure; sleeve
   gastrectomy; obesity; multidisciplinary approach
ID PRESSURE WOUND THERAPY; ANASTOMOTIC LEAKAGE; ASSISTED CLOSURE;
   GASTRECTOMY; COMPLICATIONS; STENT
AB Background and Clinical Significance: Sleeve gastrectomy is an effective and widely performed bariatric procedure that provides long-term, sustained weight loss, but it carries risks of early and late complications. Among these, gastric fistula is a rare occurrence associated with an increased mortality rate and must be carefully considered to ensure timely diagnosis and appropriate management. Case Presentation: We will present the complex case of a patient who was referred to the general surgery department due to severe abdominal pain, exertional dyspnea, nausea, fever and fatigue, symptoms that appeared one month after a robotic gastric sleeve. The investigations led to the diagnostic of high gastric fistula secondary to a gastric sleeve procedure. The patient underwent exploratory laparotomy with jejunostomy, peritoneal lavage, drainage, and endoscopic placement of an endoluminal vacuum assisted closure (E-VAC) system. Close clinical, laboratory, imaging, and endoscopic monitoring demonstrated progressive improvement, with complete resolution of the fistula achieved after seven weeks of E-VAC therapy. Conclusions: The particularity of this case lies in the occurrence of a delayed mechanical gastric suture dehiscence, with late diagnosis, managed using E-VAC. Even though rare, gastric fistulas represent a potentially life-threatening complication of sleeve gastrectomy. Early diagnosis and a multidisciplinary approach, which includes infection control, surgical intervention and minimally invasive techniques like E-VAC, are essential for effective management and favorable outcomes.
C1 [Ciuntu, Bogdan Mihnea; Maxim, Madalina; Zabara, Mihai Lucian; Abdulan, Irina Mihaela; Corlade-Andrei, Mihaela; Timofte, Daniel Vasile] Grigore T Popa Univ Med & Pharm, Fac Med, Iasi 700115, Romania.
   [Ciuntu, Bogdan Mihnea; Maxim, Madalina; Zabara, Mihai Lucian; Abdulan, Irina Mihaela; Timofte, Daniel Vasile] Cty Clin Emergency Hosp St Spiridon, Dept Gen Surg, Iasi 700111, Romania.
   [Zamfir, Alexandra-Simona] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Med Sci 3, Pulmonol, Iasi 700115, Romania.
   [Zamfir, Carmen Lacramioara] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Morpho Funct Sci 1, Iasi 700115, Romania.
   [Ciuntu, Roxana Elena] Grigore T Popa Univ Med & Pharm, Dept Ophtalmol, Iasi 700115, Romania.
   [Corlade-Andrei, Mihaela] Emergency St Spiridon Cty Hosp, Iasi 700111, Romania.
   [Balan, Gheorghe G.] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Med 1, Med Semiol & Gastroenterol, 16 Univ St, Iasi 700115, Romania.
   [Balan, Gheorghe G.] St Spiridon Cty Hosp, Gastroenterol Ward 2, Independence Bvd 1, Iasi 700111, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy
RP Zamfir, AS (通讯作者)，Grigore T Popa Univ Med & Pharm, Fac Med, Dept Med Sci 3, Pulmonol, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; simona-zamfir@umfiasi.ro;
   madalina.maxim@umfiasi.ro; carmen.zamfir@umfiasi.ro;
   roxana-elena.ciuntu@umfiasi.ro; mihai-lucian.zabara@umfiasi.ro;
   irina.abdulan@umfiasi.ro; mihaela.corlade2@umfiasi.ro;
   daniel.timofte@umfiasi.ro; gheorghe-g-balan@umfiasi.ro
RI Ciuntu, Bogdan/MTF-9477-2025; Zamfir, Carmen Lacramioara/AAG-2936-2021;
   Timofte, Daniel/AAE-2511-2019; Mihai Lucian, Zabara/JYD-6642-2024;
   Balan, Gheorghe/OZF-7157-2025; Zamfir, Alexandra-Simona/HNR-0426-2023;
   Corlade-Andrei, Mihaela/HGB-3725-2022; Abdulan, Irina/AAA-3089-2020
OI Ciuntu, Bogdan/0000-0001-7911-0699; Zamfir, Carmen
   Lacramioara/0000-0002-8431-6904; Timofte, Daniel/0000-0002-6604-874X;
   Mihai Lucian, Zabara/0000-0001-9260-6322; 
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NR 35
TC 0
Z9 1
U1 3
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD NOV 6
PY 2025
VL 15
IS 21
AR 2811
DI 10.3390/diagnostics15212811
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9RC7D
UT WOS:001613032900001
PM 41226103
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Salgarello, M
   Domar, NL
   Visconti, G
   Scardina, L
   D'Archi, S
   Di Leone, A
   Franceschini, G
   Adesi, LB
AF Salgarello, Marzia
   Lazzeri Domar, Niccolo
   Visconti, Giuseppe
   Scardina, Lorenzo
   D'archi, Sabatino
   Di Leone, Alba
   Franceschini, Gianluca
   Barone Adesi, Liliana
TI Can the Use of Closed Incision Negative Pressure Wound Therapy in
   Immediate Prepectoral Breast Reconstruction With Polyurethane-Coated
   Implants Reduce the Rate of Early Complications?: A Comparative Study
SO AESTHETIC SURGERY JOURNAL
LA English
DT Article; Early Access
ID SURGICAL SITE INFECTION; MASTECTOMY; OUTCOMES; SURGERY; RISK
AB Background: Immediate prepectoral breast reconstruction with polyurethane-coated implants provides esthetic and functional benefits compared with subpectoral techniques, but early postoperative complications remain a concern. Closed incision negative pressure wound therapy (ciNPWT) has demonstrated benefits in other surgical fields, though evidence in breast reconstruction is limited. Objectives: To evaluate whether ciNPWT reduces early postoperative complications after immediate prepectoral reconstruction with polyurethane-coated implants, particularly in high-risk patients. Methods: We retrospectively analyzed 620 patients undergoing unilateral or bilateral conservative mastectomy with immediate prepectoral reconstruction using polyurethane-coated implants between May 2021 and February 2024. Patients were divided into 2 cohorts: 257 treated with ciNPWT and 363 with conventional dressings. Subgroup analyses considered mastectomy flap thickness (0.5-0.6 cm, 0.7-0.9 cm, >= 1.0 cm) and specimen weight (<500 g vs >= 500 g). Early complications (<= 30 days) were classified as major (requiring reoperation or hospitalization) or minor. Results: ciNPWT significantly reduced major complications compared with controls: wound dehiscence (1.17% vs 6.61%), flap ischemia (0% vs 2.2%), major infection (0.39% vs 2.48%), and implant extrusion (0.39% vs 2.2%). Minor complications, including periprosthetic seromas, were also reduced (4.28% vs 5.79%). The protective effect was most evident in patients with thin mastectomy flaps (0.5-0.9 cm) and specimen weight >= 500 g. Correlation between intraoperative flap thickness and preoperative Rancati score confirmed benefits in high-risk patients (Rancati type 1). Conclusions: ciNPWT reduces early complications in immediate prepectoral reconstruction, with greatest benefit in high-risk patients. Integration into reconstructive protocols may enhance safety and broaden indications. Prospective randomized trials are warranted.
C1 [Salgarello, Marzia; Visconti, Giuseppe; Barone Adesi, Liliana] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli IRCCS, UOSD Chirurg Plast, Dipartimento Salute Donna Bambino & Sanita Publ, Rome, Italy.
   [Lazzeri Domar, Niccolo] Univ Cattolica Sacro Cuore, Residency Program in Plast Surg, Rome, Italy.
   [D'archi, Sabatino; Di Leone, Alba; Franceschini, Gianluca] Univ Cattolica Sacro Cuore, Bambino & San Pubbl Fdn Policlin Univ Agostino Gem, Dipartimento Salute Donna, UOC Chirurg Senolog, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Domar, NL (通讯作者)，Largo Agostino Gemelli 8, I-00168 Rome, Italy.
EM n.lazzeridomar@gmail.com
RI ; Salgarello, Marzia/GYJ-2938-2022; Visconti, Giuseppe/N-9292-2019;
   Scardina, Lorenzo/ABC-9506-2022; Barone-Adesi, liliana/GXV-8243-2022;
   Franceschini, Gianluca/C-5491-2016; Di Leone, Alba/AAD-2050-2022;
   D'Archi, Sabatino/M-3451-2017
OI Lazzeri Domar, Niccolò/0009-0006-3042-7082; Visconti,
   Giuseppe/0000-0002-0041-5420; Scardina, Lorenzo/0000-0002-5828-2851;
   Franceschini, Gianluca/0000-0002-2950-3395; Di Leone,
   Alba/0000-0002-8219-5336; 
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NR 44
TC 1
Z9 1
U1 1
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1090-820X
EI 1527-330X
J9 AESTHET SURG J
JI Aesthet. Surg. J.
PD 2025 NOV 11
PY 2025
DI 10.1093/asj/sjaf211
EA NOV 2025
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9SN4G
UT WOS:001613992000001
PM 41127926
OA hybrid
DA 2026-07-24
ER
PT J
AU Du, Y
   Zhai, TA
   Sheng, ZJ
   Xie, WA
   Jia, ZW
   Wen, TL
   Zhao, XY
   Tong, XL
AF Du, Ying
   Zhai, Tiangang
   Sheng, Zhujun
   Xie, Weinan
   Jia, Zhiwei
   Wen, Tianlin
   Zhao, Xiyan
   Tong, Xiaolin
TI Efficacy and Safety of Negative Pressure Wound Therapy in Diabetic Foot
   Ulcers: A Cross-Sectional Analysis of Overlapping Meta-Analyses
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE diabetic foot ulcer; negative pressure wound therapy; vacuum-assisted
   closure; systematic review; meta-analysis
ID VACUUM-ASSISTED CLOSURE; MOIST; MULTICENTER; QUALITY; TISSUE; COST
AB Objective: Negative pressure wound therapy (NPWT) is a key intervention for diabetic foot ulcers (DFUs). However, the body of meta-analytic evidence is fraught with conflicting findings, creating significant clinical uncertainty. This study was designed to harmonize the discordant evidence, identify the most methodologically robust meta-analysis, and formulate a clear, evidence-based recommendation for the clinical use of NPWT. Methods: We conducted a comprehensive search of the PubMed, Embase, and Cochrane Library databases to identify all pertinent meta-analyses. The methodological quality of each included review was rigorously assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) instrument. The Jadad decision algorithm was then employed to systematically select the most reliable and robust evidence. Results: Eight meta-analyses met the inclusion criteria, with AMSTAR scores ranging from 6 to 9. The formal application of the Jadad decision algorithm identified the meta-analysis by Deng et al as the definitive source of best available evidence. This meta-analysis demonstrated that NPWT significantly improved wound healing rates (risk ratio = 1.46) and decreased amputation rates (risk ratio = 0.69) relative to conventional therapy, while also shortening granulation tissue formation time without increasing adverse events. Conclusion: The highest-quality evidence, harmonized through this appraisal, confirms that NPWT is a safe and effective adjunctive therapy for DFUs. Its demonstrated ability to accelerate healing while reducing amputations provides a strong evidence base for consideration as a key component of standard clinical practice.
C1 [Du, Ying; Zhai, Tiangang] Beijing Univ Chinese Med, Beijing, Peoples R China.
   [Du, Ying; Jia, Zhiwei; Wen, Tianlin] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Orthoped, Beijing, Peoples R China.
   [Zhai, Tiangang; Sheng, Zhujun; Xie, Weinan; Zhao, Xiyan; Tong, Xiaolin] Guanganmen Hosp, China Acad Chinese Med Sci, Dept Endocrinol, Beijing, Peoples R China.
   [Wen, Tianlin; Tong, Xiaolin] Guanganmen Hosp, China Acad Chinese Med Sci, Dept Endocrinol, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Guang'anmen Hospital, CACMS; China Academy of Chinese Medical
   Sciences; Guang'anmen Hospital, CACMS; China Academy of Chinese Medical
   Sciences
RP Wen, TL (通讯作者)，Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Orthoped, Beijing, Peoples R China.; Tong, XL (通讯作者)，Guanganmen Hosp, China Acad Chinese Med Sci, Dept Endocrinol, Beijing, Peoples R China.; Wen, TL; Tong, XL (通讯作者)，Guanganmen Hosp, China Acad Chinese Med Sci, Dept Endocrinol, Beijing, Peoples R China.
EM wentianlin@bucm.edu.cn; tongxiaolin@vip.163.com
OI Zhao, Xiyan/0000-0002-6458-0847
FU National Natural Science Foundation of China [82205089]; Beijing Health
   Promotion Public Welfare Foundation [320.2745.2024102501]; National Key
   R & D Program of China [2022YFC3502100]; Fundamental Research Funds for
   the Central Public Welfare Research Institutes [ZZ13-YQ-030]; Scientific
   and Technological Innovation Project of China Academy of Chinese Medical
   Sciences [CI2021A01614]; Clinical Research Center Construction Project
   of Guang'anmen Hospital, CACMS [2022LYJSZX13, HLCMHPP2023009, 9323002]
FX National Natural Science Foundation of China (82205089) , Beijing Health
   Promotion Public Welfare Foundation (320.2745.2024102501) , National Key
   R & D Program of China (2022YFC3502100) , Fundamental Research Funds for
   the Central Public Welfare Research Institutes (ZZ13-YQ-030) ,
   Scientific and Technological Innovation Project of China Academy of
   Chinese Medical Sciences (CI2021A01614) , Clinical Research Center
   Construction Project of Guang'anmen Hospital, CACMS (2022LYJSZX13) ,
   High Level Chinese Medical Hospital Promotion Project (HLCMHPP2023009) ,
   The Escort Project of Guang'anmen Hospital, China Academy of Chinese
   Medical Science-Backbone Talent Cultivation Project (9323002) .
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NR 72
TC 0
Z9 0
U1 1
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2025
VL 18
BP 4099
EP 4112
DI 10.2147/DMSO.S565993
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9SO0Z
UT WOS:001614009700001
PM 41245737
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU Coronel, EF
   Faleiro, MD
   Sarmento, PAD
   Soares, FP
   Sulzbach, CJ
   Fonseca, MK
AF Coronel, Eduardo Furtado
   Faleiro, Matheus Daniel
   Sarmento, Pedro Adolfo de Andrade
   Soares, Fabiano Pasqualotto
   Sulzbach, Carla Jeanine
   Fonseca, Mariana Kumaira
TI A complex scalp wound following a myiasis infestation: cranial burr
   holes and negative pressure wound therapy
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE granulation tissue; myiasis; negative pressure wound therapy; scalp;
   trephination; wound; wound care; wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; BONE
AB Myiasis is a parasitic infection common in tropical areas,<br /> such as Brazil. It is caused by infestation of maggots of various fly species in humans. Here, the case of a 38-year-old female patient, with no comorbidities, who was referred to the authors' centre due to a scalp wound infested with larvae and complete soft tissue loss, is presented. A computed tomography scan revealed no evidence of osteomyelitis or intracranial compromise. Since the initial<br /> debridement and mechanical removal of the larvae resulted in a large and complex wound, the patient underwent a combined wound approach based on cranial burr holes and negative pressure wound therapy followed by skin graft. The wound revealed excellent skin graft survival, and the patient was safely discharged home. No complications were observed in the follow-up period.<br />
C1 [Coronel, Eduardo Furtado; Faleiro, Matheus Daniel; Fonseca, Mariana Kumaira] Hosp Pronto Socorro Porto Alegre, Gen & Trauma Surg Serv, Porto Alegre, Brazil.
   [Faleiro, Matheus Daniel] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil.
   [Sarmento, Pedro Adolfo de Andrade] Univ Estacio Sa, Rio De Janeiro, Brazil.
   [Soares, Fabiano Pasqualotto] Hosp Pronto Socorro Porto Alegre, Neurosurg Serv, Porto Alegre, Brazil.
   [Sulzbach, Carla Jeanine] Hosp Pronto Socorro Porto Alegre, Plast Surg Serv, Porto Alegre, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Estacio de Sa
RP Fonseca, MK (通讯作者)，Hosp Pronto Socorro Porto Alegre, Gen & Trauma Surg Serv, Porto Alegre, Brazil.
EM mariana.kumaira@gmail.com
OI Daniel Faleiro, Matheus/0000-0003-1075-9494
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2025
VL 34
IS 10
BP 870
EP 873
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 9SU2K
UT WOS:001614170200001
PM 41071309
DA 2026-07-24
ER
PT J
AU Nakamura, H
   Makiguchi, T
   Hino, A
   Shirabe, K
   Yokoo, S
AF Nakamura, Hideharu
   Makiguchi, Takaya
   Hino, Ayumu
   Shirabe, Ken
   Yokoo, Satoshi
TI Effect on bacterial load of a DACC-coated dressing as a wound contact
   layer in negative pressure wound therapy
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE bacterial load; DACC; dialkylcarbamoyl chloride-coated dressing;
   negative pressure wound therapy; skin graft; Sorbact; ulcer; wound;
   wound care; wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; INFECTION; ULCERS
AB Objective: Dialkylcarbamoyl chloride (DACC)-coated dressing is hydrophobic material that absorbs exudate and binds the bacteria within it to the dressing. This property has led to the use of DACC-coated dressings for a wide range of wounds. However, the bacterial load binding capacity in this dressing used with negative pressure wound therapy (NPWT) has not been evaluated, to the best of the authors' knowledge. The aim of this study was to examine bacterial loads at the wound surface in the use of NPWT with a DACC-coated dressing as a wound contact layer. Method: A single-centre study was performed in patients with skin ulcers who had received a split-thickness skin graft (STSG). Each skin ulcer was divided into two comparable regions, one covered with a DACC-coated dressing (Sorbact Compress; Abigo Medical AB, Sweden) (DACC group) and the other with silicone gauze (control group). NPWT was used to fix the STSG. Swab samples were collected from the wound surface and the number of bacterial colony-forming units (CFUs) was measured to assess bacterial load on the day of surgery (day 0) and upon NPWT removal on day 7 postoperatively. Skin graft survival rates were compared between the two groups. Results: The experimental cohort comprised 15 patients, yielding 15 paired regions per group (DACC and control). On day 0, there was no difference in the number of CFUs between the control and DACC groups (p=0.136). However, on day 7, the DACC group had a lower CFU count than the control group (p=0.0175). The skin graft survival rate did not differ significantly between the two groups (p=0.938). Conclusion: In this study, use of a DACC-coated dressing reduced bacterial growth when using NPWT. This suggests that this combination treatment might contribute to the promotion of wound healing. Declaration of interest: The authors have no conflicts of interest.
C1 [Nakamura, Hideharu] Natl Hosp Org Takasaki Gen Med Ctr, Dept Plast & Reconstruct Surg, Takasaki, Japan.
   [Makiguchi, Takaya; Yokoo, Satoshi] Gunma Univ, Dept Oral & Maxillofacial Surg, Grad Sch Med, Maebashi, Japan.
   [Hino, Ayumu] Natl Hosp Org Takasaki Gen Med Ctr, Dept Clin Lab Sci, Takasaki, Japan.
   [Shirabe, Ken] Gunma Univ, Grad Sch Med, Dept Gen Surg Sci, Maebashi, Japan.
C3 Gunma University; Gunma University
RP Nakamura, H (通讯作者)，Natl Hosp Org Takasaki Gen Med Ctr, Dept Plast & Reconstruct Surg, Takasaki, Japan.
EM hidemoku0211@gmail.com
OI Nakamura, Hideharu/0000-0001-9603-2805
CR Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
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   World Health Organization, Ten threats to global health in 2019
   Wu CC, 2015, ADV SKIN WOUND CARE, V28, P21, DOI 10.1097/01.ASW.0000459038.81701.fb
NR 31
TC 1
Z9 1
U1 1
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2025
VL 34
IS 11
BP 952
EP 956
DI 10.12968/jowc.2023.0058
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 9TM2A
UT WOS:001614638200001
PM 41201877
DA 2026-07-24
ER
PT J
AU Wilson, K
   Sims, T
AF Wilson, Karie
   Sims, Terran
TI Use of Negative Pressure Wound Therapy in Selected Cases to Facilitate
   Abdominal Wound Healing
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Exposed bowel; Negative pressure wound therapy; NPWT; Peristomal wound;
   Surgical wound dehiscence
ID DEHISCENCE
AB BACKGROUND:Surgical wound dehiscence resulting in exposed bowel increases the risk for development of an enterocutaneous fistula. Consequently, management of exposed bowel in an open wound presents challenges in terms of wound care management. In addition, a surgical wound dehiscence within the peristomal plane of an ileal conduit also creates a complex challenge of maintaining an ostomy pouching system seal.CASES:Case 1 was a patient with peristomal skin complications requiring stoma re-siting and subsequent surgical wound dehiscence at the prior ostomy site. As a result, we addressed wound management in the setting of urinary leakage from the ileal conduit. We used negative pressure wound therapy (NPWT) in the setting of a peristomal dehisced surgical wound to promote healing and optimize peristomal skin health. Case 2 was a patient with an infected surgical incision requiring readmission to hospital and additional surgery. Intra-operative findings revealed a fascial defect with exposed bowel in the wound resulting in unique challenges for wound management. Again, we used NPWT in the setting of exposed bowel to promote granulation and achieve wound closure.CONCLUSION:Research regarding ideal wound management for complex open abdominal wounds with exposed bowel is sparse. These case studies summarize our clinical experience managing complex patients with wound dehiscence and abdominal fascia defects and risk of enterocutaneous fistula formation with NPWT.
C1 [Wilson, Karie] Univ Virginia Hlth Syst, Dept Urol, 1222 Lee St, Charlottesville, VA 22903 USA.
   [Sims, Terran] Univ Virginia, Dept Urol, Charlottesville, VA USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia
RP Wilson, K (通讯作者)，Univ Virginia Hlth Syst, Dept Urol, 1222 Lee St, Charlottesville, VA 22903 USA.
EM kaw2y@uvahealth.org; tws4m@uvahealth.org
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Chandrasekhar V, 2020, WOUND MANAG PREV, V66, P37, DOI 10.25270/wmp.2020.5.3845
   Cheng Y, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013710.pub2
   Chetter IC, 2019, INT J NURS STUD, V89, P62, DOI 10.1016/j.ijnurstu.2018.09.011
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   Cwalinski J, 2023, ADV SKIN WOUND CARE, V36, P435, DOI 10.1097/ASW.0000000000000006
   Kim S, 2020, TRIALS, V21, DOI 10.1186/s13063-019-3925-z
   Morinaga K, 2019, ANN PLAS SURG, V82, P213, DOI 10.1097/SAP.0000000000001739
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   Wagner JC, 2021, LANGENBECK ARCH SURG, V406, P2479, DOI 10.1007/s00423-021-02221-w
NR 11
TC 0
Z9 0
U1 2
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD NOV-DEC
PY 2025
VL 52
IS 6
BP 503
EP 509
DI 10.1097/WON.0000000000001233
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 9TY3B
UT WOS:001614954000001
PM 41235852
DA 2026-07-24
ER
PT J
AU Zhu, LY
   Zheng, SY
   Li, YP
   Liu, P
AF Zhu, Liyong
   Zheng, Shunyang
   Li, Yongpan
   Liu, Pei
TI Efficacy and safety of vacuum sealing drainage combined with skin
   grafting for the treatment of limb burns
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Burns; Limb; Skin grafting; Vacuum sealing drainage
ID PRESSURE WOUND THERAPY
AB Objective: Exploring the efficacy and safety of vacuum sealing drainage (VSD) combined with skin grafting for limb burns. Methodology: This retrospective cohort study collected clinical records of 140 patients with limb burns who underwent skin grafting surgery in Yongkang First People's Hospital from November, 2021 to October, 2024. Among them, 70 patients who received the first stage VSD combined with the second stage skin grafting treatment (VSD group) were matched in a 1:1 ratio with the queue of patients who received a traditional dressing change treatment combined with the second stage skin grafting treatment (conventional group). The healing time, granulation growth time, length of hospital stay, scar hyperplasia (as assessed by the Vancouver Scar Scale, VSS), degree of pain and incidence of complications were compared. Results: The healing time, granulation growth time, length of hospital stay and VSS score of the VSD group were lower than those of the conventional group (P<0.05). The VAS scores of the VSD group were lower compared to the conventional group at one, three and seven days after treatment (P<0.05). VSD combined with skin grafting was associated with a significantly lower (18.6%) incidence of complications than the conventional treatment (34.3%) (P<0.05). Conclusions: VSD combined with skin grafting is safer than the traditional treatment approach and is more efficient in shortening the wound healing process and reducing pain and scar formation in patients with limb burns.
C1 [Zhu, Liyong; Zheng, Shunyang; Li, Yongpan; Liu, Pei] Yongkang First Peoples Hosp, Emergency Dept ED, 599 Jinshan West Rd, Yongkang 321300, Zhejiang, Peoples R China.
RP Zhu, LY (通讯作者)，Yongkang First Peoples Hosp, Emergency Dept ED, 599 Jinshan West Rd, Yongkang 321300, Zhejiang, Peoples R China.
EM 18757897820@163.com
CR Ahmed M, 2023, J PAK MED ASSOC, V73, P1567, DOI 10.47391/JPMA.7991
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NR 21
TC 0
Z9 0
U1 0
U2 0
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
EI 1681-715X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD NOV
PY 2025
VL 41
IS 11
BP 3105
EP 3110
DI 10.12669/pjms.41.11.12555
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9UA4J
UT WOS:001615010500014
PM 41394387
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Andrews, E
   Arko-Cobbah, E
   Bruwer, F
   Laher, S
   Miseer, S
   Moeng, MS
   Ngcakani, A
   Scott, D
   Vadia, S
   Trivedi, S
AF Andrews, Ethel
   Arko-cobbah, Emmanuel
   Bruwer, Febe
   Laher, Saadia
   Miseer, Sanesh
   Moeng, Maeyane S.
   Ngcakani, Anati
   Scott, Devan
   Vadia, Suleman
   Trivedi, Sadhana
TI Negative Pressure Wound Therapy With Instillation and Closed Incision
   Negative Pressure Therapy Use in South Africa: Expert Panel
   Recommendations
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE closed incision negative pressure therapy; consensus recommendations;
   negative pressure wound therapy with instillation; South Africa
ID HIGH-RISK PATIENTS; MAJOR MUSCLE FLAP; DWELL TIME; CARE; COMPLICATIONS;
   INFECTION; PREVALENCE; MANAGEMENT; DRESSINGS; STANDARD
AB The healthcare landscape in South Africa is challenging with a complex patient population and a stressed healthcare system. Negative pressure therapy-based systems such as negative pressure wound therapy with instillation and dwell (NPWTi-d) and closed incision negative pressure therapy (ciNPT) can help manage wounds or incisions. However, guidelines for South Africa-specific use are limited. An in-person meeting was held with 10 experts to develop South Africa-specific therapy use recommendations for NPWTi-d and ciNPT. Panel members recommended NPWTi-d use for wounds in need of cleansing. Normal saline and a 10-min dwell time were recommended with the caveat that the instillation solutions and dwell times can be changed based on the wound bed condition and the features of the instillation solution. A negative pressure cycle of 2-3 h and a negative pressure of -125 mmHg were also recommended for NPWTi-d. In patients, incisions, and surgical procedures at high risk of developing surgical site complications, ciNPT use was recommended. These general recommendations serve as a framework for NPWTi-d and/or ciNPT use in South Africa and should be updated as more region-specific evidence becomes available.
C1 [Andrews, Ethel] Univ Witwatersrand, Nursing Educ, Johannesburg, South Africa.
   [Arko-cobbah, Emmanuel] Mediclin Bloemfontein, Surg, Bloemfontein, South Africa.
   [Bruwer, Febe] Life Roseacres Hosp, Adv Wound Care, Germiston, South Africa.
   [Laher, Saadia] Netcare Alberton Hosp, Plast & Reconstruct Surg, Alberton, South Africa.
   [Laher, Saadia] Midvaal Hosp, Plast & Reconstruct Surg, Johannesburg, South Africa.
   [Miseer, Sanesh] Tygerberg Acad Hosp, Orthopaed, Cape Town, South Africa.
   [Moeng, Maeyane S.] Univ Witwatersrand, Trauma Surg, Johannesburg, South Africa.
   [Ngcakani, Anati] Edenvale Gen Hosp, Orthopaed, Edenvale, South Africa.
   [Scott, Devan] Life Anncron Hosp, Cardiothorac Surg, Klerksdorp, South Africa.
   [Vadia, Suleman] Netcare Milpk & Rosebank Hosp, Plast Reconstruct & Cosmet Surg, Johannesburg, South Africa.
   [Trivedi, Sadhana] Solventum, Med Surg, Dublin, Ireland.
C3 University of Witwatersrand; University of Witwatersrand
RP Trivedi, S (通讯作者)，Solventum, Med Surg, Dublin, Ireland.
EM strivedi2@solventum.com
RI MOENG, Maeyane Stephens/OPN-3614-2025; Bruwer, Febe
   Antoinette/MTC-0199-2025
OI MOENG, Maeyane Stephens/0000-0001-7459-3388; Bruwer, Febe
   Antoinette/0000-0003-0947-0159; 
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NR 69
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD NOV 16
PY 2025
VL 22
IS 11
AR e70790
DI 10.1111/iwj.70790
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 9UY2T
UT WOS:001615635400001
PM 41230876
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Schimmer, C
   Heinowski, C
   Hamouda, K
   Meybohm, P
   Madrahimov, N
   Färber, G
   Radakovic, D
AF Schimmer, Christoph
   Heinowski, Christina
   Hamouda, Khaled
   Meybohm, Patrick
   Madrahimov, Nodir
   Farber, Gloria
   Radakovic, Dejan
TI Variables Associated with Treatment Failure after Negative Pressure
   Wound Therapy in Poststernotomy Mediastinitis: A Case-Control Study
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article; Early Access
DE poststernotomy mediastinitis; negative pressure wound therapy; therapy
   failure
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; RECONSTRUCTION; FLAP
AB Background: This study investigated factors leading to treatment failure after negative pressure wound therapy (NPWT) in poststernotomy mediastinitis (PSM) patients. Methods: A single-center retrospective case-control study in 198 cardiac surgery patients with PSM and consecutive NPWT were retrospectively divided into two groups. Group I consisted of patients whose NPWT was successful (n = 117/198; 59.1%), while in Group II treatment, failure occurred (n = 81/198; 40.9%). The primary endpoint was treatment failure, defined as recurrence of wound infection requiring surgical treatment within 30 days after secondary wound closure. Results: Body mass index (BMI) >30 kg/m(2) (p = 0.04; odds ratio [OR] 1.07), diabetes mellitus (DM; p = 0.03; OR 1.94), and the number of sponge changes (p = 0.01; OR 1.57) showed an association with the occurrence of NPWT failure. During the study period, 10/198 (19.8%) patients died after secondary wound healing. In group I, 1/117 (0.9%) patient died versus group II with 9/81 (12.7%) patients. About 70% patients died from septic multiple organ failure. Conclusion: This study confirms that variables associated with treatment failure after NPWT in PSM are BMI >30 kg/m(2), diabetes mellitus (DM), and the "number of sponge changes," respectively. However, this does not mean that sponge changes increase the risk; rather, sponge changes are associated with more resistant germs, incomplete wound healing, and more aggressive infection. This implies that management should be in the hands of cardiac surgeons with extensive experience in septic surgery and at centers with expertise in order to minimize the duration of NPWT and thus the number of sponge changes.
C1 [Schimmer, Christoph; Hamouda, Khaled; Farber, Gloria; Radakovic, Dejan] Univ Hosp Wurzburg, Dept Cardiothorac & Thorac Vasc Surg, Wurzburg, Germany.
   [Heinowski, Christina; Meybohm, Patrick] Univ Hosp Wurzburg, Dept Anaesthesiol Intens Care Emergency & Pain Med, Wurzburg, Germany.
   [Madrahimov, Nodir] Julius Maximilians Univ Hosp Wuerzburg, Dept Thorac & Cardiovasc Surg, Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg
RP Schimmer, C (通讯作者)，Univ Hosp Wurzburg, Dept Cardiothorac & Thorac Vasc Surg, Wurzburg, Germany.
EM schimmer_c@ukw.de
RI Meybohm, Patrick/KEE-5745-2024; Färber, Gloria/JAN-9598-2023
OI Meybohm, Patrick/0000-0002-2666-8696; Färber, Gloria/0000-0002-2153-2458
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NR 17
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD 2025 NOV 13
PY 2025
DI 10.1055/a-2733-4361
EA NOV 2025
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 9UY7B
UT WOS:001615646600001
PM 41167592
DA 2026-07-24
ER
PT J
AU Walther, A
   De Marco, G
   Vazquez, O
   Steiger, C
   Boudabbous, S
   Dayer, R
   Ceroni, D
AF Walther, Adrien
   De Marco, Giacomo
   Vazquez, Oscar
   Steiger, Christina
   Boudabbous, Sana
   Dayer, Romain
   Ceroni, Dimitri
TI Synchronous Multifocal Necrotizing Fasciitis in an Infant: A Case Report
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE Synchronous; multifocal; necrotizing fasciitis; pediatric; magnetic
   resonance imaging; surgery; <italic>Streptococcus pyogenes</italic>
ID LABORATORY RISK INDICATOR; SOFT-TISSUE INFECTIONS; LRINEC SCORE;
   CELLULITIS; MORTALITY; DIAGNOSIS; SECONDARY; SHOCK; SKIN
AB We report an exceptional form of a synchronous multifocal necrotizing fasciitis (NF) affecting a 16-month-old girl. A high clinical suspicion of NF was confirmed by her laboratory risk indicators for necrotizing fasciitis score and magnetic resonance imaging. Blood cultures were positive for Streptococcus pyogenes. Successful outcomes were achieved through antibiotic treatment and an isolated surgical exploration using negative-pressure wound therapy.
C1 [Walther, Adrien; Vazquez, Oscar; Steiger, Christina; Boudabbous, Sana; Dayer, Romain; Ceroni, Dimitri] Geneva Univ Hosp, Dept Women Child & Adolescent, Pediat Surg Serv, Pediat Orthoped Unit, CH-1211 Geneva, Switzerland.
   [Dayer, Romain] Geneva Univ Hosp, Radiol Dept, CH-1211 Geneva, Switzerland.
C3 University of Geneva; University of Geneva
RP Ceroni, D (通讯作者)，Geneva Univ Hosp, Dept Woman Child & Adolescent, Pediat Surg Serv, Pediat Orthoped Unit, 6 Rue Willy Donze, CH-1206 Geneva, Switzerland.
EM giacomo.demarco@hug.ch; oscar.vazquez@hug.ch; christina.steiger@hug.ch;
   sana.boudabbous@hug.ch; romain.dayer@hug.ch; dimitri.ceroni@hug.ch
RI boudabbous, sana/AAM-9368-2020
OI Vazquez, Oscar/0000-0002-1325-8575
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NR 46
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0891-3668
EI 1532-0987
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD DEC
PY 2025
VL 44
IS 12
BP e459
EP e462
DI 10.1097/INF.0000000000004900
PG 4
WC Immunology; Infectious Diseases; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Pediatrics
GA 9VT1P
UT WOS:001616181700009
PM 40526874
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Liu, GF
   Ding, XY
   Li, QY
   Chu, X
   Deng, YB
   Cui, SJ
   Zhou, L
   Xing, CF
   Sun, XH
   Zhang, J
AF Liu, Gaofeng
   Ding, Xiaoyong
   Li, Qingyuan
   Chu, Xia
   Deng, Yingbiao
   Cui, Sujuan
   Zhou, Li
   Xing, Chaofeng
   Sun, Xiaohang
   Zhang, Jie
TI Application of composite layered repair system using titanium mesh, bone
   cement and vacuum sealing drainage for chest wall defect
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE chest wall defect; titanium mesh; bone cement; vacuum sealing drainage;
   reconstruction
ID LATISSIMUS-DORSI FLAP; METHYL-METHACRYLATE; POLYPROPYLENE MESH;
   RECONSTRUCTION; RESECTION; PROSTHESIS; EXPERIENCE
AB Objective To evaluate the therapeutic efficacy of a composite layered repair system utilizing titanium mesh (TM), bone cement (BC) and vacuum sealing drainage (VSD) for chest wall defect reconstruction, providing a reliable theoretical foundation and practical guidance for clinical chest wall trauma management.Method A thoracic defect model (>= 6 x 6 cm2) was established in 22 adult goat and then divided into the TM + BC + VSD, TM + BC and TM + VSD groups. The survival status, activity status, wound recovery, vital signs, blood routine, arterial blood gas and inflammatory factor levels of the three goat groups were monitored and compared after the operation.Result All groups demonstrated comparable survival rates and periods with satisfactory defect repair outcomes. The PaO2 at multiple time points after surgery in the TM + BC + VSD group were higher than those in the TM + BC and TM + VSD groups, while the activity status score, WBC and levels of PaCO2, IL-2, IL-6, IL-10, IL-17 and TNF-alpha were lower than those in the TM + BC and TM + VSD groups. The SpO2, hemoglobin and erythrocyte were higher than those in the TM + VSD group, and the wound healing score, heart rate was lower than that in the TM + VSD group.Conclusion The composite laminated repair system constructed by TM, BC and VSD can increase the survival rate after chest wall defect repair, promote functional recovery, improve oxygenation and reduce inflammatory responses, and has potential clinical application value.
C1 [Liu, Gaofeng; Ding, Xiaoyong; Li, Qingyuan; Chu, Xia; Deng, Yingbiao; Cui, Sujuan; Zhou, Li; Xing, Chaofeng; Sun, Xiaohang] PLA, 988th Hosp Joint Logist Support Forces, Zhengzhou, Henan, Peoples R China.
   [Zhang, Jie] Peoples Liberat Army Gen Hosp, Beijing North Med Dist, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital
RP Sun, XH (通讯作者)，PLA, 988th Hosp Joint Logist Support Forces, Zhengzhou, Henan, Peoples R China.; Zhang, J (通讯作者)，Peoples Liberat Army Gen Hosp, Beijing North Med Dist, Beijing, Peoples R China.
EM xhangsun@163.com; zhjj608@sina.com
OI Zhang, Jie/0009-0009-7805-8548
FU Henan Province Medical Science and technology joint construction project
   [LHGJ20200788]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This study was supported by
   Henan Province Medical Science and technology joint construction project
   (NO. LHGJ20200788).
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NR 41
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD OCT 30
PY 2025
VL 12
AR 1681418
DI 10.3389/fmed.2025.1681418
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9VT5D
UT WOS:001616191100001
PM 41262448
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Vallejo-Carmona, L
AF Vallejo-Carmona, Leticia
TI Structure-guided negative pressure wound therapy (NPWT) : personalised
   tissue biomodulation with an NPWT system in adults and older adults
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE Negative pressure wound therapy; near-infrared spectroscopy; wound
   healing; perfusion; tissue oxygenation; biomodulation
ID VACUUM-ASSISTED CLOSURE; SILVER; RECOMMENDATIONS; MULTICENTER
AB Background: Negative pressure wound therapy(NPWT) has revolutionised the management of complex wounds via mechanisms such as microdeformation, angiogenesis and exudate control. However, its clinical effect has historically only been evaluated by qualitative and visual parameters. This study integrates near-infrared spectroscopy (NIRS) as a biofeedback tool to quantify physiological response to NPWT in real time. Objective: This study aimed to quantitatively demonstrate the physiological and structural changes induced by an NPWT system in patients with complex wounds, measured using NIRS. Methods: A prospective real-world observational study was conducted with a cohort of 23 patients with 33 wounds. Structural and physiological parameters were documented before and after NPWT treatment. Random-intercept mixed-effect statistical models and pre-post comparison tests were used to assess clinical and physiological significance. Results: The data showed a progressive reduction in wound area and volume, accompanied by an increase in tissue oxygen saturation and a sustained decrease in deoxygenated haemoglobin. These findings, objectively quantified through NIRS as a real-time biofeedback tool, highlight the improvement in oxygenation and wound-bed perfusion and support the hypothesis of tissue biomodulation induced by NPWT. Conclusion: The integration of NIRS redefines the clinical role of NPWT, allowing therapy to be customised based on specific physiological data. This combination represents a new frontier in precision wound medicine. The results of this study provide a foundation for a new generation of clinical decisions in advanced wound management.
C1 [Vallejo-Carmona, Leticia] Puerto Rico Wound Healing Soc, Wound Care Plus Educ & Res Ctr, Orlando, FL 32801 USA.
   [Vallejo-Carmona, Leticia] Wound & Ulcer Ctr Florida, Wound & Ulcer Care Clin San Juan, Orlando, FL 32801 USA.
   [Vallejo-Carmona, Leticia] Ana G Mendez Univ, Dept Hlth Sci, San Juan, PR 00928 USA.
C3 Universidad Ana G. Mendez
RP Vallejo-Carmona, L (通讯作者)，Puerto Rico Wound Healing Soc, Wound Care Plus Educ & Res Ctr, Orlando, FL 32801 USA.; Vallejo-Carmona, L (通讯作者)，Wound & Ulcer Ctr Florida, Wound & Ulcer Care Clin San Juan, Orlando, FL 32801 USA.; Vallejo-Carmona, L (通讯作者)，Ana G Mendez Univ, Dept Hlth Sci, San Juan, PR 00928 USA.
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NR 57
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2025
VL 34
IS 11
SU B
PG 24
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 9WK2C
UT WOS:001616629000001
DA 2026-07-24
ER
PT J
AU Abu-Khudir, R
   Doghish, AS
   Mansour, RM
   Sayed, GA
   Elshami, NH
   Moustafa, HAM
   Elkalla, WS
   Abdulkader, AO
   Mageed, SSA
   Mohammed, OA
   Hamad, RS
   Abulsoud, AI
   Zaki, MB
   Elrebehy, MA
   Abdelfatah, AM
   Salah, AN
AF Abu-Khudir, Rasha
   Doghish, Ahmed S.
   Mansour, Reda M.
   Sayed, Ghadir A.
   Elshami, Nourhan H.
   Moustafa, Hebatallah Ahmed Mohamed
   Elkalla, Wagiha S.
   Abdulkader, Ahmed O.
   Mageed, Sherif S. Abdel
   Mohammed, Osama A.
   Hamad, Rabab S.
   Abulsoud, Ahmed I.
   Zaki, Mohamed Bakr
   Elrebehy, Mahmoud A.
   Abdelfatah, Amr M.
   Salah, Akram N.
TI Infection control and wound care innovations in plastic surgery: a
   multidisciplinary approach
SO FOLIA MICROBIOLOGICA
LA English
DT Review
DE Plastic surgery; Wound healing; Postoperative complication; Wound
   infection; Postoperative infections
ID SURGICAL SITE INFECTIONS; ANTIBIOTIC-PROPHYLAXIS; NOSOCOMIAL INFECTIONS;
   MICROBIOLOGY; MANAGEMENT; OUTCOMES; SKIN; METAANALYSIS; ASSOCIATION;
   PREVENTION
AB An infection that develops after plastic or reconstructive surgery is one of the most common and difficult consequences to deal with. In addition to compromising functional recovery and cosmetic outcomes, these infections can greatly lengthen hospital stays, raise patient morbidity, and slow wound healing. Infection risk in plastic surgery is complex and multifaceted, necessitating an all-encompassing and preventative strategy. Strict aseptic surgical procedures, perioperative antibiotic prophylaxis based on procedure type and patient risk profile, and comprehensive preoperative skin preparation to decrease microbial load are important preventive strategies. Significantly less infection risk can be achieved with patient optimization prior to surgery by controlling comorbidities like diabetes, correcting dietary deficiencies, stopping smoking, and managing immunosuppressive conditions. New approaches to wound care have emerged that promise to speed up the healing process while simultaneously decreasing the incidence of infections. Some of these methods include using antimicrobial dressings that release silver or iodine over time, using negative pressure wound therapy to increase blood flow and drain excess fluid, and utilizing bioengineered scaffolds and matrices rich in growth factors to stimulate cell proliferation and angiogenesis. Preventing deep tissue involvement and surgical site infection requires early diagnosis of infection signals and rapid action. The purpose of this review is to highlight current evidence-based methods and advances in the field of plastic surgery that aim to reduce infections and enhance wound healing. It also emphasizes the significance of an integrated, multidisciplinary approach in order to improve both the functional and aesthetic outcomes of surgical procedures.
C1 [Abu-Khudir, Rasha] King Faisal Univ, Coll Sci, Dept Chem, POB 380, Al Hasa 31982, Hofuf, Saudi Arabia.
   [Doghish, Ahmed S.] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Nasr 11231, Cairo, Egypt.
   [Doghish, Ahmed S.] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Badr 11829, Cairo, Egypt.
   [Mansour, Reda M.] Badr Univ Cairo, Sch Biotechnol, Mol Biol & Biotechnol Dept, Badr City 11829, Cairo, Egypt.
   [Mansour, Reda M.] Helwan Univ, Fac Sci, Zool & Entomol Dept, Helwan 11795, Egypt.
   [Sayed, Ghadir A.] Egyptian Russian Univ, Fac Pharm, Dept Biochem, Cairo, Egypt.
   [Elshami, Nourhan H.] Ain Shams Univ, Fac Pharm, Dept Microbiol & Immunol, Org African Unity St, Abbasiya 11566, Cairo, Egypt.
   [Moustafa, Hebatallah Ahmed Mohamed] Badr Univ Cairo BUC, Fac Pharm, Dept Clin Pharm & Pharm Practice, Badr 11829, Cairo, Egypt.
   [Elkalla, Wagiha S.; Abdulkader, Ahmed O.; Salah, Akram N.] Badr Univ Cairo BUC, Fac Pharm, Microbiol & Immunol Dept, Badr 11829, Cairo, Egypt.
   [Mageed, Sherif S. Abdel] Badr Univ Cairo BUC, Fac Pharm, Pharmacol & Toxicol Dept, Badr 11829, Cairo, Egypt.
   [Mohammed, Osama A.] Univ Bisha, Coll Med, Dept Pharmacol, Bisha 61922, Saudi Arabia.
   [Hamad, Rabab S.] King Faisal Univ, Coll Sci, Biol Sci Dept, Al Hasa 31982, Saudi Arabia.
   [Abulsoud, Ahmed I.] Heliopolis Univ, Fac Pharm, Integrat Hlth Ctr, Cairo 11785, Egypt.
   [Abulsoud, Ahmed I.] Al Azhar Univ, Fac Pharm Boys, Nasr 11231, Cairo, Egypt.
   [Zaki, Mohamed Bakr] Univ Sadat City, Fac Pharm, Dept Biochem, Sadat 32897, Egypt.
   [Zaki, Mohamed Bakr] Menoufia Natl Univ, Fac Pharm, Dept Biochem, km Cairo Alexandria Agr Rd, Menoufia, Egypt.
   [Elrebehy, Mahmoud A.] Galala Univ, Fac Pharm, Dept Biochem, New Galala 43713, Suez, Egypt.
   [Abdelfatah, Amr M.] Badr Univ Cairo, Fac Pharm, Dept Pharmaceut Analyt Chem, Badr 11829, Cairo, Egypt.
C3 King Faisal University; Egyptian Knowledge Bank (EKB); Al Azhar
   University; Badr University in Cairo; Badr University in Cairo; Egyptian
   Knowledge Bank (EKB); Capital University - Egypt; Egyptian Russian
   University; Egyptian Knowledge Bank (EKB); Ain Shams University; Badr
   University in Cairo; Badr University in Cairo; Badr University in Cairo;
   University of Bisha; King Faisal University; Egyptian Knowledge Bank
   (EKB); Heliopolis University; Egyptian Knowledge Bank (EKB); Al Azhar
   University; Egyptian Knowledge Bank (EKB); University of Sadat City;
   Galala University; Badr University in Cairo
RP Abu-Khudir, R (通讯作者)，King Faisal Univ, Coll Sci, Dept Chem, POB 380, Al Hasa 31982, Hofuf, Saudi Arabia.; Doghish, AS (通讯作者)，Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Nasr 11231, Cairo, Egypt.; Doghish, AS (通讯作者)，Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Badr 11829, Cairo, Egypt.
EM rabukhudir@kfu.edu.sa; ahmed_doghish@azhar.edu.eg
RI Hamad, Rabab/H-9104-2016; Moustafa, hebatallah/NXX-9279-2025; mansour,
   reda/ACW-5693-2022; Elrebehy, Mahmoud/LZF-1181-2025; Soliman Doghish,
   Ahmed/AAB-4004-2021; Abulsoud, Ahmed/Y-1116-2018; Abu-Khudir,
   Rasha/JHT-1566-2023; sabry, sherif/HPF-9803-2023; Bakr,
   Mohamed/HGA-5685-2022; Bastawesy, Ghadir/IWM-6990-2023; Mohammed, Osama
   A/IRZ-5046-2023
OI Moustafa, hebatallah/0000-0003-4530-406X; Soliman Doghish,
   Ahmed/0000-0002-0136-7096; Mohammed, Osama A/0000-0001-9712-9609;
   Elshami, Nourhan H/0009-0006-2401-4660
FU Deanship of Scientific Research, Vice Presidency for Graduate Studies
   and Scientific Research, King Faisal University, Saudi Arabia
   [KFU253706]
FX This work was supported by the Deanship of Scientific Research, Vice
   Presidency for Graduate Studies and Scientific Research, King Faisal
   University, Saudi Arabia [Grant No. KFU253706].
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NR 117
TC 1
Z9 1
U1 4
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0015-5632
EI 1874-9356
J9 FOLIA MICROBIOL
JI Folia Microbiol.
PD APR
PY 2026
VL 71
IS 2
BP 215
EP 234
DI 10.1007/s12223-025-01373-2
EA NOV 2025
PG 20
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA HX5IP
UT WOS:001616647100001
PM 41252064
DA 2026-07-24
ER
PT J
AU Xu, CZ
   Zhou, WJ
   Zou, XD
   Dong, YZ
   Alhaskawi, A
   Zhou, HY
   Lu, H
AF Xu, Chuze
   Zhou, Weijie
   Zou, Xiaodi
   Dong, Yanzhao
   Alhaskawi, Ahmad
   Zhou, Haiying
   Lu, Hui
TI Case Report on Necrotizing Fasciitis after Liposuction and
   Abdominoplasty
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE jove.com/video/69043
ID LABORATORY RISK INDICATOR; COMPLICATION RATES; SURGERY; SAFETY;
   MANAGEMENT; DIAGNOSIS; SCORE; SKIN; TOOL
AB Liposuction and abdominoplasty are common cosmetic procedures, but they can lead to severe complications such as necrotizing fasciitis (NF), which is a life-threatening infection with rapid progression and significant mortality rates. NF can develop after surgical procedures due to bacterial colonization or inadequate postoperative care. In the case shown here, a 33-year-old woman presented with skin flap fascial necrosis with abdominal wall infection 20 days after undergoing abdominoplasty with liposuction at another private clinic. Initial management included incision and drainage of an abdominal wall sinus tract, debridement of necrotic tissue, and application of antibiotic bone cement, followed by vacuum sealing drainage (VSD). Postoperative blood tests and bacterial culture identified multiple pathogens, all susceptible to quinolones. Subsequent surgeries involved re-debridement and skin grafting. The patient received a comprehensive rehabilitation program, resulting in effective infection control and favorable outcomes. The case underscores the importance of early diagnosis and aggressive surgical debridement in managing NF. The use of antibiotic bone cement provided local high-concentration antibiotics and supported granulation tissue formation, contributing to the treatment of the wound. This rare complication highlights the potential risks of cosmetic surgery and the necessity of strict adherence to aseptic techniques.
C1 [Xu, Chuze] Wenzhou Med Univ, Sch Optometry & Ophthalmol, Wenzhou, Peoples R China.
   [Xu, Chuze; Zhou, Weijie; Zou, Xiaodi; Dong, Yanzhao; Alhaskawi, Ahmad; Zhou, Haiying; Lu, Hui] Zhejiang Univ, Affiliated Hosp 1, Dept Orthoped, Hangzhou, Peoples R China.
C3 Wenzhou Medical University; Zhejiang University
RP Lu, H (通讯作者)，Zhejiang Univ, Affiliated Hosp 1, Dept Orthoped, Hangzhou, Peoples R China.
EM huilu@zju.edu.cn
RI ; Dong, Yanzhao/KAM-2859-2024
OI lu, hui/0000-0002-5921-1043; 
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NR 49
TC 0
Z9 0
U1 1
U2 5
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD OCT
PY 2025
IS 224
AR e69043
DI 10.3791/69043
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 9WL1P
UT WOS:001616653700005
PM 41115143
DA 2026-07-24
ER
PT J
AU Mcmillan, A
   Yates, G
   Chambers, B
AF Mcmillan, Aj
   Yates, Gd
   Chambers, Ba
TI Vacuum-assisted closure as a component of the management of deep surgery
   site infection after canine cementless total hip replacement
SO AUSTRALIAN VETERINARY JOURNAL
LA English
DT Article
DE infection; negative pressue wound therapy; total hip replacement; vacuum
   assisted closure
ID PRESSURE WOUND THERAPY; DISTAL EXTREMITY; SKIN-GRAFTS; COMPLICATIONS;
   DEVICE
AB This case report presents the incorporation of vacuum-assisted closure (VAC) in the successful management of a deep, multiresistant surgery site infection after cementless total hip replacement (THR) in a dog. It outlines the rationale, technique used and clinical efficacy of the approach. The role of VAC in human orthopedic infections is discussed and potential refinements of the technique are proposed.
C1 [Mcmillan, Aj; Yates, Gd; Chambers, Ba] Ctr Anim Referral & Emergency, Collingwood, Vic, Australia.
RP Mcmillan, A (通讯作者)，Ctr Anim Referral & Emergency, Collingwood, Vic, Australia.
EM amcmillan@carevet.com.au
OI McMillan, Angus/0009-0008-6323-7618
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NR 25
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0005-0423
EI 1751-0813
J9 AUST VET J
JI Aust. Vet. J.
PD MAR
PY 2026
VL 104
IS 3
BP 131
EP 136
DI 10.1111/avj.70040
EA NOV 2025
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA EU9MZ
UT WOS:001617526100001
PM 41253308
OA Bronze
DA 2026-07-24
ER
PT J
AU Kawashima, K
   Esmaeili, A
AF Kawashima, Kazuho
   Esmaeili, Ali
TI Negative Pressure Wound Therapy in Free Flap Reconstruction: A
   Systematic Review and Meta-Analysis
SO MICROSURGERY
LA English
DT Review
DE free flaps; free tissue transfer; negative pressure wound therapy; VAC
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; LOWER-EXTREMITY;
   MICROSURGICAL RECONSTRUCTION; IMPLANTABLE DOPPLER; MUSCLE; MULTICENTER;
   EXPERIENCE; SALVAGE
AB Background Despite extensive research on negative pressure wound therapy (NPWT), its impact on immediate post-operative application in free flap reconstruction remains underexplored. The objective of this systematic review and meta-analysis is to evaluate the efficacy of NPWT compared with conventional wound therapy (CWT) in post-operative management of free flap, focusing on flap survival, complication rates, and flap size.Methods Searches were carried out in CENTRAL, Medline, and Embase. All prospective or retrospective clinical studies examining the effect of immediate post-operative application of NPWT after free flap reconstruction were considered for the review. No restrictions were placed on the date of publication but only papers written in English were included.Results 13 studies were included in the review, with 6 studies eligible for the meta-analysis. A total of 321 free flaps were included in the pooled analysis. NPWT reduced overall complication rates compared with CWT (OR 0.34, 95% CI 0.13 to 0.88, p = 0.03, n = 240) and also resulted in a statistically significant reduction in flap size (SMD -1.54, 95% CI -2.48 to -0.54, p = 0.002, n = 43). However, there was no significant difference in flap survival rates (OR 2.34, 95% CI 0.77 to 7.09, p = 0.13, n = 252).Conclusion NPWT appears to offer benefits over CWT in reducing complications and flap size, but precautions should be taken in interpreting these results. Further high-quality randomized controlled trials are required to validate these findings.
C1 [Kawashima, Kazuho] UCL, Div Surg & Intervent Sci, London, England.
   [Kawashima, Kazuho; Esmaeili, Ali] Royal Free NHS Fdn Trust, Dept Plast & Reconstruct Surg, London, England.
   [Esmaeili, Ali] Univ London, London, England.
C3 University of London; University College London; University of London
RP Kawashima, K (通讯作者)，UCL, Div Surg & Intervent Sci, London, England.; Kawashima, K (通讯作者)，Royal Free NHS Fdn Trust, Dept Plast & Reconstruct Surg, London, England.
EM kazuho.kawashima@nhs.net
OI Esmaeili, Ali/0009-0003-5280-2574; Kawahima, Kazuho/0009-0001-3436-6516
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PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD NOV 19
PY 2025
VL 45
IS 8
AR e70144
DI 10.1002/micr.70144
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9YF8K
UT WOS:001617875500001
PM 41257533
DA 2026-07-24
ER
PT J
AU Gao, Q
   Wei, YK
   Fan, XR
   Xu, WJ
   Gu, PF
   Liu, S
   Han, Y
AF Gao, Qiang
   Wei, Yukun
   Fan, Xiaorui
   Xu, Wenjian
   Gu, Pengfei
   Liu, Song
   Han, Yong
TI Delayed tracheal injury following total thyroidectomy: case report and
   literature review
SO BMC SURGERY
LA English
DT Review
DE Total thyroidectomy; Delayed tracheal injury; Tracheal injury;
   Subcutaneous emphysema
ID TRACHEOBRONCHIAL INJURIES
AB A 51-year-old woman developed extensive subcutaneous emphysema on postoperative day 7 following total thyroidectomy with central lymph node dissection for thyroid cancer, indicating delayed tracheal injury. Emergency surgery revealed rupture of inter-tracheal ring ligaments and connective tissue, resulting in a necrotic 3 x 2 cm wound with purulent exudate. Necrotic tissue was debrided until viable bleeding margins were achieved. Infection was controlled using vacuum sealing drainage (VSD) with continuous negative-pressure drainage and anti-infective therapy. The tracheostomy tube was subsequently inserted, replaced, and eventually removed without incident, and the patient recovered fully before discharge. This rare complication highlights impaired tracheal blood supply as a key etiology for necrosis. Timely diagnosis and staged surgical intervention are critical for managing post-thyroidectomy tracheal injuries.
C1 [Gao, Qiang; Gu, Pengfei; Liu, Song; Han, Yong] Binzhou Med Univ Hosp, Dept Thyroid Surg, Binzhou, Shandong, Peoples R China.
   [Gao, Qiang] Soochow Univ, Affiliated Hosp 2, Suzhou, Jiangsu, Peoples R China.
   [Wei, Yukun; Fan, Xiaorui; Xu, Wenjian] Binzhou Med Univ, Clin Med Coll 1, Binzhou, Shandong, Peoples R China.
C3 Shandong Medical & Pharmaceutical University; Soochow University -
   China; Shandong Medical & Pharmaceutical University
RP Han, Y (通讯作者)，Binzhou Med Univ Hosp, Dept Thyroid Surg, Binzhou, Shandong, Peoples R China.
EM hanyong2021@126.com
RI Gu, Pengfei/HNQ-0051-2023
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NR 10
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Z9 0
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD NOV 18
PY 2025
VL 25
IS 1
AR 556
DI 10.1186/s12893-025-03287-9
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9YM3X
UT WOS:001618045800001
PM 41254651
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gefen, A
   Russo, S
   Ciliberti, M
AF Gefen, Amit
   Russo, Serena
   Ciliberti, Marino
TI Revisiting negative pressure wound therapy from a mechanobiological
   perspective supported by clinical and pathological data
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE chronic wound care; influence zone theory; mechanisms of action;
   neo-angiogenesis; ultrasound Doppler
ID VACUUM-ASSISTED CLOSURE; CELL-SHAPE; RECOMMENDATIONS; DEFORMATIONS;
   MECHANISMS; DRESSINGS
AB Negative pressure wound therapy is used often in the management of surgical incisions, chronic wounds and subacute lesions, and there are numerous publications discussing its clinical application and outcomes. However, whilst clinical use and associated literature have expanded since these systems became commercially available in the 90s, important research and discussion around the mode of action have waned, leading to a deficit in the understanding of how this important therapy influences healing. Further, much research and many publications are predominantly reflective, discussing early theorem, some of which have been proven incorrect, or at least not fully resolved leading to misunderstandings as to how the therapy works, thus potentially denying the clinician the opportunity to optimise use towards improved clinical and economic outcomes. In this narrative review, we discuss established beliefs and challenges to same where appropriate and introduce important new research that addresses the manner in which mechanical strain energy (i.e., deformations) is transferred to tissue and how this influences biological response and healing. In addition, we assess and discuss the effect of different negative pressure dressing formats, how they influence the mode of action and how this understanding can lead to more efficient and effective use and clinical economic outcomes.
C1 [Gefen, Amit] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-69978 Tel Aviv, Israel.
   [Gefen, Amit] Univ Ghent, Univ Ctr Nursing & Midwifery, Dept Publ Hlth & Primary Care, Skin Integr Res Grp SKINT, Ghent, Belgium.
   [Gefen, Amit] Hasselt Univ, Fac Sci, Dept Math & Stat, Hasselt, Belgium.
   [Gefen, Amit] Hasselt Univ, Data Sci Inst, Fac Sci, Hasselt, Belgium.
   [Russo, Serena] Mediterranean Inst Transplantat & Highly Specializ, Palermo, Italy.
   [Ciliberti, Marino] Ctr Aziendale Riparaz Tissutale, Wound Care Ctr, Castellammare Di Stabia, Italy.
C3 Tel Aviv University; Ghent University; Ghent University Hospital;
   Hasselt University; Hasselt University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-69978 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
FU Mlnlycke Health Care; Ministry of Innovation, Science and Technology
   [001702603]
FX The authors are thankful to Mr. Brian Andrews (Global Marketing,
   Negative Pressure Wound Therapy, Molnlycke Health Care, Gothenburg,
   Sweden) whose vast industry experience contributed to the relevance of
   this work. This work was partially supported by the Israeli Ministry of
   Innovation, Science and Technology (Breakthrough Research Program Grant
   no. 001702603, awarded to Professor Amit Gefen in 2023). Authors AG and
   MC are paid consultants for Molnlycke Health Care.
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NR 50
TC 6
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2024
VL 21
IS 12
AR e70098
DI 10.1111/iwj.70098
PG 16
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 9ZY1I
UT WOS:001619032800001
PM 39694469
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Espinosa-de-los-Monteros, A
   Mosqueda-Larrauri, VL
   Sanchez-Pereda, D
   Gamboa-Lopez, CA
AF Espinosa-de-los-Monteros, Antonio
   Mosqueda-Larrauri, Virna Lisi
   Sanchez-Pereda, Diego
   Gamboa-Lopez, Christian Alessandro
TI Postoperative Outcomes of Incisional Negative Pressure Wound Therapy in
   Patients Undergoing Abdominoplasty, Horizontal Panniculectomy, or
   Harvest of TRAM or DIEP Flaps
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE abdominoplasty; panniculectomy; transversus abdominis flap; deep
   inferior epigastric perforator flap; negative pressure wound therapy
ID ABDOMINAL DONOR-SITE; VENTRAL HERNIA REPAIR; BREAST RECONSTRUCTION;
   SPINAL-FUSION; COMPLICATIONS
AB Abdominoplasty, horizontal panniculectomy and TRAM/DIEP flaps can sometimes be associated to postoperative complications such as wound dehiscence, skin necrosis, seroma, hematoma, surgical site infection, and need for unplanned reoperation. The purpose of this study is to provide an estimate of the clinical effects that iNPWT has on those outcomes, based on the available literature. Twelve studies met the inclusion criteria and were included in the systematic review. From these, 11 studies were comparative and suitable for meta-analysis. Results showed that the use of iNPWT is associated to a significant decrease in the rates of postoperative wound dehiscence and need for unplanned reoperation. There was no statistically significant difference in the rates of postoperative skin necrosis, seroma, hematoma, and surgical site infection.
C1 [Espinosa-de-los-Monteros, Antonio; Mosqueda-Larrauri, Virna Lisi; Sanchez-Pereda, Diego; Gamboa-Lopez, Christian Alessandro] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Div Plast Surg, Vasco Quiroga 15, Mexico City 14000, DF, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico
RP Espinosa-de-los-Monteros, A (通讯作者)，Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Div Plast Surg, Vasco Quiroga 15, Mexico City 14000, DF, Mexico.
EM aedlms@hotmail.com; vmosquedalarrauri@gmail.com;
   sanchezperedadiego@gmail.com; christiangamboamd@gmail.com
OI Gamboa Lopez, Christian Alessano/0009-0003-8398-4171
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NR 45
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2025
VL 95
IS 6
BP 752
EP 759
DI 10.1097/SAP.0000000000004478
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A4085
UT WOS:001619491700011
PM 41133907
DA 2026-07-24
ER
PT J
AU Jayle, C
   Allain, G
   Buono, A
   Van, SD
   D'Ostrevy, N
   Kermen, S
   Picardo, A
   Pelras, A
   Drux, J
   Corbi, P
   Billot, M
   Frasca, D
AF Jayle, Christophe
   Allain, Geraldine
   Buono, Amandine
   Van, Simon Dang
   D'Ostrevy, Nicolas
   Kermen, Stephane
   Picardo, Alessandro
   Pelras, Antoine
   Drux, Julie
   Corbi, Pierre
   Billot, Maxime
   Frasca, Denis
TI Reduction of the risk of complete sternotomy scar dehiscence in cardiac
   surgery: a protocol for a randomised, open-label multicentre clinical
   investigation comparing negative pressure wound therapy (NPWT) versus
   standard dressing (PRISTER study)
SO BMJ OPEN
LA English
DT Article
DE Patients; Cardiac surgery; WOUND MANAGEMENT; Infection control
ID INFECTIONS; PREVENTION; MANAGEMENT
AB Introduction Cardiac surgical procedures are associated with a high incidence of postoperative infection, a risk attributed to their inherently invasive nature and extended duration. The goal of this study is to evaluate the efficacy of negative pressure wound therapy (NPWT) compared with standard dressings in preventing sternal scar dehiscence in patients undergoing cardiac surgery via complete vertical midline sternotomy, comparing a 3 day change system (NPWT 3/7 d) versus a 7 day wear system (NPWT 7d) versus standard dressings.Methods and analysis The PRISTER study is a prospective open-label multicentre, randomised, controlled, three-arm trial. Patients aged >= 18 years and meeting all the following inclusion criteria: patients undergoing scheduled or semiurgent cardiac surgery, with or without extracorporeal circulation, and patients managed by complete vertical median sternotomy will be recruited. Total sample size will consist of 660 patients. The primary outcome, surgical wound dehiscence after complete median sternotomy, expressed as occurrence or non-occurrence during the first 30 postoperative days, will be assessed by tablet calibrated photos analysed by an independent blinded staff. The secondary outcomes will be the number of dressing repairs between D7 (excluding initial protocol) and D90, length of initial hospital stay, occurrence of surgical site infection and its classification collected on day 90 (D90), use of an anti-infectious treatment and its duration, incidence of postoperative mediastinitis defined by dehiscence of the sternum with positive sternal samples, incidence of surgical revision for dehiscence of the surgical wound at D90 and collection of all operations involving surgical revision of the sternotomy wound, number of rehospitalisations (including hospital consultations) and their duration (evaluated at D90). Medicoeconomic assessment will be assessed by evaluation of hospital and extrahospital costs (number of days in hospital, consultations, rehospitalisations, imaging, biology and drugs), dressing costs and patient quality of life by EQ-5D-5L.Ethics and dissemination The study was approved by the French Agency for the Safety of Health Products (ANSM, Agence National de S & eacute;curit & eacute; du M & eacute;dicament) as well as by the Ethics Committee (CPP Ile de France VIII) N degrees ID-RCB: 2023-A01782-43. Recruitment began in April 2024 and ended on 26 May 2025.Trial registration number clinicaltrials.gov NCT06207630.
C1 [Jayle, Christophe; Allain, Geraldine; Drux, Julie; Corbi, Pierre] CHU Poitiers, Serv Chirurg Thorac & Cardiovasc, Poitiers, France.
   [Jayle, Christophe; Buono, Amandine; Billot, Maxime] Univ Poitiers, Ctr Invest Clin Domaine Innovat Technol CIC IT 140, INSERM, CHU Poitiers, Poitiers, France.
   [Van, Simon Dang] Angers Univ Hosp, Serv Chirurg Cardiaque, Angers, France.
   [D'Ostrevy, Nicolas] CHU Clermont Ferrand, Serv Chirurg Cardiovasc, Clermont Ferrand, France.
   [Kermen, Stephane] CHU Tours, Serv Chirurg Cardiaque, Tours, France.
   [Picardo, Alessandro] CHU Limoges, Serv Chirurg Thorac & Cardiovasc, Limoges, France.
   [Pelras, Antoine] CHU Poitiers, Poitiers, France.
   [Billot, Maxime] Univ Poitiers, Ctr Rech Cognit & Apprentissage, UMR7295, CNRS, Poitiers, France.
   [Frasca, Denis] CHU Poitiers, Serv Anesthesie Reanimat & Med Perioperatoir, Poitiers, France.
C3 CHU Poitiers; Universite de Poitiers; CHU Poitiers; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de Poitiers;
   Universite d'Angers; Centre Hospitalier Universitaire d'Angers;
   Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; CHU Tours; CHU
   Limoges; Universite de Poitiers; CHU Poitiers; Universite de Poitiers;
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); CHU Poitiers; Universite de Poitiers
RP Billot, M (通讯作者)，Univ Poitiers, Ctr Invest Clin Domaine Innovat Technol CIC IT 140, INSERM, CHU Poitiers, Poitiers, France.; Billot, M (通讯作者)，Univ Poitiers, Ctr Rech Cognit & Apprentissage, UMR7295, CNRS, Poitiers, France.
EM christophe.jayle@chu-poitiers.fr; geraldine.allain@chu-poitiers.fr;
   amandine.buono@chu-poitiers.fr; simon.dangvan@chu-angers.fr;
   ndostrevy@chu-clermontferrand.fr; s.kermen@chu-tours.fr;
   Alessandro.Piccardo@chu-limoges.fr; Antoine.PELRAS@chu-poitiers.fr;
   Julie.DRUX@chu-poitiers.fr; pierre.corbi@chu-poitiers.fr;
   maxime.billot@chu-poitiers.fr; denis.frasca@chu-poitiers.fr
RI Billot, Maxime/J-3518-2012; d'ostrevy, nicolas/AAO-2100-2020
OI Billot, Maxime/0000-0003-0979-2182; 
FU French public health services [PHRC-N]
FX This study received funding in 2022 from the French public health
   services 'Direction Generale de l'Offre de Soins (DGOS)' through a
   National Hospital Clinical Research Program.
CR Biancari F, 2022, J CLIN MED, V11, DOI 10.3390/jcm11154268
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NR 19
TC 0
Z9 0
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD NOV 18
PY 2025
VL 15
IS 11
AR e104226
DI 10.1136/bmjopen-2025-104226
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C0858
UT WOS:001620171400001
PM 41263903
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ioannidis, O
   Brenta, A
   Theodorou, A
   Siozos, K
   Gemousakakis, G
   Anestiadou, E
   Klonou, E
   Symeonidis, SK
   Bitsianis, S
   Kotidis, E
   Mantzoros, I
   Pramateftakis, MG
   Angelopoulos, S
AF Ioannidis, Orestis
   Brenta, Aliki
   Theodorou, Alexis
   Siozos, Konstantinos
   Gemousakakis, Georgios
   Anestiadou, Elissavet
   Klonou, Ekaterini
   Symeonidis, Savvas Konstantinos
   Bitsianis, Stefanos
   Kotidis, Efstathios
   Mantzoros, Ioannis
   Pramateftakis, Manousos Georgios
   Angelopoulos, Stamatios
TI Early results from the use of an innovative vertical fascial traction
   system for the management of patients with open abdomen
SO FRONTIERS IN SURGERY
LA English
DT Article
DE open abdomen; fascial traction; fascial closure device; trauma; sepsis
ID PRESSURE WOUND THERAPY; ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED
   CLOSURE; DIRECT PERITONEAL RESUSCITATION; DAMAGE-CONTROL LAPAROTOMY;
   VENTRAL HERNIA REPAIR; INTRAABDOMINAL HYPERTENSION; WALL RECONSTRUCTION;
   TRAUMA; SURGERY
AB Background The combination of negative pressure wound therapy (NPWT) with dynamic fascial traction is currently considered the preferred method for temporary closure of the open abdomen (OA). However, this approach often requires repeated returns to the operating room for further fascial approximation. The aim of this study was to present our institution's experience with a vertical fascial traction device (VTD) for OA management and early closure.Methods This is a prospective registry of patients treated with the VTD between May 2023 and the present. The system used is commercially named Fasciotens (R) Abdomen, manufactured by Fasciotens GmbH (Essen, Germany).Results Definitive abdominal closure was achieved in 11 of 13 patients. Eight patients underwent primary midline suture, while 3 patients-all with pre-existing hernias-required mesh reinforcement. Two patients died before closure could be performed.Conclusions The vertical fascial traction device applies continuous upward traction to the rectus abdominis fascia through an external frame anchored to the pelvis and thorax, thereby increasing abdominal compartment volume and reducing intra-abdominal pressure. This innovative technique facilitates earlier and safer abdominal wall closure and represents a promising adjunct in the management of the open abdomen.
C1 [Ioannidis, Orestis; Brenta, Aliki; Siozos, Konstantinos; Gemousakakis, Georgios; Anestiadou, Elissavet; Klonou, Ekaterini; Symeonidis, Savvas Konstantinos; Bitsianis, Stefanos; Kotidis, Efstathios; Mantzoros, Ioannis; Pramateftakis, Manousos Georgios; Angelopoulos, Stamatios] Aristotle Univ Thessaloniki, Gen Hosp Thessaloniki G Papanikolaou, Fac Hlth Sci, Sch Med,Dept Surg 4, Thessaloniki, Greece.
   [Theodorou, Alexis] Univ Athens, Hippocratio Hosp Athens, Propaedeut Dept Surg 21, Athens, Greece.
C3 Aristotle University of Thessaloniki; George Papanikolaou General
   Hospital of Thessaloniki; National & Kapodistrian University of Athens
RP Ioannidis, O (通讯作者)，Aristotle Univ Thessaloniki, Gen Hosp Thessaloniki G Papanikolaou, Fac Hlth Sci, Sch Med,Dept Surg 4, Thessaloniki, Greece.
EM telonakos@hotmail.com
RI Bitsianis, Stefanos/PLC-1440-2026
OI Bitsianis, Stefanos/0000-0001-8281-1189
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NR 79
TC 4
Z9 4
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD NOV 11
PY 2025
VL 12
AR 1644791
DI 10.3389/fsurg.2025.1644791
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA D7368
UT WOS:001621832300001
PM 41306790
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liang, Y
   Liu, ZJ
   Wang, X
   Ma, Q
   Hu, XY
AF Liang, Yuan
   Liu, Zhenjiang
   Wang, Xin
   Ma, Qiang
   Hu, Xinyong
TI Experience in diagnosis and treatment of pediatric fibular osteomyelitis
SO FRONTIERS IN SURGERY
LA English
DT Article
DE fibula osteomyelitis; children; surgical intervention; vacuum sealing
   drainage; conservative treatment
ID MASQUELET TECHNIQUE
AB Objective To summarize and analyze the clinical characteristics, diagnosis, treatment, and prognosis of pediatric fibular osteomyelitis, and to analyze related influencing factors, providing evidence for clinical management of pediatric osteomyelitis in rare locations.Methods A retrospective analysis was conducted on the clinical data of pediatric patients with fibular osteomyelitis from January 2018 to December 2024, including demographic characteristics, clinical manifestations, laboratory and imaging examinations, microbiological results, treatment modalities, and follow-up outcomes.Results A total of 13 patients were included (9 males, 4 females) with a median age of onset of 7.3 years. There were 11 acute cases and 2 chronic cases. The main clinical manifestations were bone pain, fever, and local abscess formation. The positive rate of microbiological culture was 76.9%, with Staphylococcus aureus being the most common pathogen (including 1 case of MRSA). Two patients responded effectively to antibiotic therapy alone, while 11 cases required surgical intervention, including fibular fenestration, debridement, segmental resection, and VSD therapy. All patients showed significant reduction in inflammatory markers after treatment. During 3-24 months of follow-up, 3 cases experienced recurrence requiring repeat surgery, with no severe disability or deformity observed.Conclusion Pediatric fibular osteomyelitis has an insidious onset and poses diagnostic challenges. Staphylococcus aureus, particularly MRSA, represents the primary pathogen, with higher rates of surgical intervention and recurrence compared to other long bones. Early accurate diagnosis, adequate antibiotic therapy, and individualized surgical intervention are crucial for improving prognosis.
C1 [Liang, Yuan; Liu, Zhenjiang; Wang, Xin; Ma, Qiang; Hu, Xinyong] Capital Med Univ, Capital Inst Pediat, Capital Ctr Childrens Hlth, Dept Orthoped, Beijing, Peoples R China.
C3 Capital Institute of Pediatrics (CIP); Capital Medical University
RP Liu, ZJ (通讯作者)，Capital Med Univ, Capital Inst Pediat, Capital Ctr Childrens Hlth, Dept Orthoped, Beijing, Peoples R China.
EM lzjsdd@163.com
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NR 16
TC 0
Z9 0
U1 2
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD NOV 11
PY 2025
VL 12
AR 1671156
DI 10.3389/fsurg.2025.1671156
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA D8040
UT WOS:001621899600001
PM 41306792
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Czerny-Bednarczyk, K
   Slabon, A
   Ziolkowska, K
   Klama-Baryla, A
   Wielgorecki, A
   Gierek, M
   Strzelec, P
   Labus, W
AF Czerny-Bednarczyk, Katarzyna
   Slabon, Anna
   Ziolkowska, Karolina
   Klama-Baryla, Agnieszka
   Wielgorecki, Artur
   Gierek, Marcin
   Strzelec, Przemyslaw
   Labus, Wojciech
TI Tissue engineering as a tool in a novel approach to the comprehensive
   treatment and management of a deeply and extensively burned patient:
   case report
SO CELL AND TISSUE BANKING
LA English
DT Article
DE Severe burn wound; Human acellular dermal matrix; Human amnion graft; In
   vitro cultured keratinocytes and fibroblasts; Negative pressure wound
   therapy; Laser speckle contrast analysis; High-frequency USG
ID THICKNESS SKIN-GRAFT; AMNIOTIC MEMBRANE; DERMAL SUBSTITUTE; WOUND
   EXCISION; IN-HOUSE; THERAPY; RECONSTRUCTION; KERATINOCYTES; OUTCOMES
AB Deep and extensive thermal burns with concurrent inhalation injuries can be associated with a high mortality rate, especially among elderly patients. Injuries of this type require treatment in highly. specialized centers. Early excision and autografting are the standard of care for extensive, deep burns. To achieve a functionally and aesthetically satisfactory burn scar, allogeneic acellular dermal matrices (ADMs) can be used as co-grafts alongside autologous split-thickness skin grafts (STSGs). Additionally, the application of in vitro-cultured autologous keratinocytes and fibroblasts has been shown to accelerate burn wound healing. Allogeneic amnion transplantation can also be performed to promote healing at donor sites. This paper presents a case report of a 65 year-old patient with thermal burns covering 26% total body surface area (TBSA) with third-degree burns affecting the thorax, abdomen, back, right shoulder, right elbow, and right thigh, as well as airway involvement. The patient underwent multistage surgical treatment, including deep excision of necrotic tissues. The wound was treated using a combination of ADM, free STSG, in vitro-cultured skin cells, and local negative pressure wound therapy (NPWT). Allogeneic amnion grafts were applied to the donor sites, which were used multiple times after healing. Healing progress was monitored using laser speckle contrast analysis (LASCA). Additionally, scar viscoelasticity, transepidermal water loss, melanin content, epidermal thickness, and temperature were examined post-healing. Selected skin parameters were also assessed using high-frequency ultrasound. The patient was discharged on day 77, having spent 41 days in the surgical ward and 36 days in the rehabilitation ward, with fully healed wounds. It is important to note that rehabilitation began on the first day of hospitalization. Follow-up visits documented gradual improvement in the evaluated scar parameters.
C1 [Czerny-Bednarczyk, Katarzyna; Slabon, Anna; Ziolkowska, Karolina; Klama-Baryla, Agnieszka; Wielgorecki, Artur; Gierek, Marcin; Strzelec, Przemyslaw; Labus, Wojciech] Stanislaw Sakiel Burn Treatment Ctr Siemianowice S, Jana Pawla 2 St, PL-41100 Siemianowice Slaskie, Poland.
   [Slabon, Anna] Med Univ Silesia, Doctoral Sch, Fac Hlth Sci Bytom, PL-41902 Katowice, Bytom, Poland.
C3 Medical University of Silesia
RP Czerny-Bednarczyk, K; Labus, W (通讯作者)，Stanislaw Sakiel Burn Treatment Ctr Siemianowice S, Jana Pawla 2 St, PL-41100 Siemianowice Slaskie, Poland.
EM katarzyna.czerny@clo.com.pl; wojciech.labus@gmail.com
RI Gierek, Marcin/AAE-1727-2022; Łabuś, Wojciech/I-3141-2019
OI Czerny-Bednarczyk, Katarzyna/0009-0005-2269-3009; Łabuś,
   Wojciech/0000-0003-2108-9270; Wielgórecki, Artur/0009-0004-1063-9112
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NR 58
TC 1
Z9 1
U1 2
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9333
EI 1573-6814
J9 CELL TISSUE BANK
JI Cell Tissue Banking
PD NOV 24
PY 2025
VL 27
IS 1
AR 2
DI 10.1007/s10561-025-10203-1
PG 19
WC Cell Biology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA E2233
UT WOS:001622322200004
PM 41284087
DA 2026-07-24
ER
PT J
AU Sivash, II
   Koval, BM
AF Sivash, Iurii I.
   Koval, Boris M.
TI Negative pressure wound therapy for combat-related extremity vascular
   injuries: clinical experience from the war in Ukraine
SO SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
LA English
DT Article
DE NPWT; Combat extremity vascular trauma; Limb salvage; Soft-tissue
   defect; War in Ukraine
ID VACUUM-ASSISTED CLOSURE; INFECTIOUS COMPLICATIONS; MANAGEMENT; IRAQ;
   EPIDEMIOLOGY; FRACTURES; SURGERY; GRAFT
AB BackgroundExtremity vascular injuries are among the most challenging problems in military surgery. They are frequently accompanied by extensive soft tissue loss and heavy contamination, which increases the risk of infection and limb loss. Although negative pressure wound therapy (NPWT) is widely used in civilian practice, its role in combat vascular injuries remains unclear. The war in Ukraine provided an opportunity to evaluate NPWT as part of staged surgical care under modern battlefield conditions.MethodsWe retrospectively reviewed 85 service members with severe combat-related extremity vascular injuries admitted to a Role IV facility in 2022. Among these patients, 69/85 (81.2%) had extensive soft-tissue defects overlying vascular reconstructions and received NPWT; this subgroup constituted the analytic cohort. A standardised two-layer NPWT technique was used: an inner nonadherent barrier/PVA sponge directly over the reconstruction site and an outer polyurethane foam connected to continuous -70 to -80 mmHg. The dressing was changed every 3-4 days. The outcomes included infectious complications, erosion-related bleeding, arterial thrombosis, secondary amputation, the method of definitive wound closure, and the length of stay.ResultsThe mechanisms of injury were mine blast (71%), gunshot (23%), and other explosive trauma (6%). Combined arterial-venous injuries occurred in 40% (n = 28/69), fractures in 42% (n = 29/69), and primary wound contamination in 57% (n = 39/69) of the patients. Definitive closure was achieved by primary approximation in 75.4% (n = 52/69), skin grafting in 17.4% (n = 12/69), and flap techniques in 4.3% (n = 3/69). Complications occurred in 27.5% (n = 19/69): erosion-related bleeding (13%, n = 9/69), arterial thrombosis (8.7%, n = 6/69), and infection (5.8%, n = 4/69). Erosion-related bleeding clustered in two risk windows: days 7-10 and 18-30. Secondary amputation was required in 2.9% (n = 2/69); in-hospital mortality was 0%.ConclusionsA two-layer NPWT protocol at -70 to -80 mmHg was a safe and effective adjunct in the staged management of combat-related extremity vascular injuries with extensive soft-tissue defects. This approach is associated with the preservation of vascular reconstructions and limbs, low infection and amputation rates, the mitigation of erosion-related bleeding, and timely wound closure. Prospective multicenter studies are needed to optimise and standardise NPWT protocols in this setting.
C1 [Sivash, Iurii I.; Koval, Boris M.] Natl Mil Med Clin Ctr, Main Mil Clin Hosp, Kiev, Ukraine.
   [Sivash, Iurii I.; Koval, Boris M.] Bogomolets Natl Med Univ, Kiev, Ukraine.
C3 Bogomolets National Medical University
RP Sivash, II (通讯作者)，Natl Mil Med Clin Ctr, Main Mil Clin Hosp, Kiev, Ukraine.; Sivash, II (通讯作者)，Bogomolets Natl Med Univ, Kiev, Ukraine.
EM y.sivash@gmail.com; kovalboris@gmail.com
OI Sivash, Iurii/0000-0002-7956-6378
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NR 45
TC 1
Z9 3
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1757-7241
J9 SCAND J TRAUMA RESUS
JI Scand. J. Trauma Resusc. Emerg. Med.
PD NOV 25
PY 2025
VL 33
IS 1
AR 188
DI 10.1186/s13049-025-01502-3
PG 12
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA E5141
UT WOS:001622613000001
PM 41291788
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Garten, A
   Nherera, LM
   Lindsay, R
AF Garten, Alison
   Nherera, Leo M.
   Lindsay, Rodney
TI Comparison of Single Use and Traditional Negative Pressure Wound Therapy
   Devices in Lower Extremity Ulcers: A US Real-World Evidence Analysis of
   NetHealth Data
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE diabetic foot ulcer; lower extremity ulcer; single-use negative pressure
   wound therapy; traditional negative pressure wound therapy; venous leg
   ulcer
ID DIABETIC FOOT ULCERS; VACUUM-ASSISTED CLOSURE; VENOUS LEG ULCERS; COST;
   BURDEN; CLASSIFICATION; MANAGEMENT; MEDICARE; SOCIETY; UPDATE
AB Annually, 49 million people worldwide are impacted by lower extremity ulcers (LEUs). Diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) are the most common LEUs. Negative pressure wound therapy (NPWT) has emerged as an effective intervention for complex wounds, offering numerous favourable wound healing outcomes. The objective of this study was to evaluate the effectiveness of single-use NPWT (sNPWT) versus traditional NPWT (tNPWT) for wound closure in LEUs. Real-world data was obtained from the US-based Net Health outpatient database between January 2014 and October 2020 and included patients with LEUs (DFU or VLU) who had been treated with sNPWT or tNPWT. The rate of wound closure and time to wound closure were selected as endpoints. The wound closure rate was significantly higher for all LEUs (p = 0.039), VLUs alone (p = 0.003) and there was no difference for DFU (p = 0.90) that were treated with sNPWT versus tNPWT. The median time to wound closure was significantly shorter for sNPWT (114 days) compared to tNPWT (140 days, p < 0.01). Using sNPWT was associated with significantly higher wound closure rates and shorter time to wound closure. The results provide supportive evidence for using sNPWT for LEUs, demonstrating the opportunity to directly decrease the clinical burden of LEUs on patients. Subgroup analysis revealed a significant difference in wound closure rates for VLU, while no significant difference was observed for DFU. The overall LEU findings may be attributed to differences in the mechanisms of action between the two devices.
C1 [Garten, Alison] Charlotte Limb Preservat & Diabetic Foot Ctr, Charlotte, NC 28210 USA.
   [Nherera, Leo M.] Smith Nephew Inc, Ft Worth, TX USA.
   [Lindsay, Rodney] Carrollton Reg Med Ctr, Carrollton, TX USA.
C3 Smith & Nephew
RP Garten, A (通讯作者)，Charlotte Limb Preservat & Diabetic Foot Ctr, Charlotte, NC 28210 USA.
EM drgartenaawp@gmail.com
FU Smith and Nephew Inc.
FX This study was funded by Smith and Nephew Inc.
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NR 66
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP 4
PY 2025
VL 22
IS 9
AR e70756
DI 10.1111/iwj.70756
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA E9421
UT WOS:001623043700001
PM 40908001
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Badia, JM
   Rubio-Pérez, I
   Morales-Pérez, C
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   Masià, J
   Balibrea, JM
AF Badia, Josep M.
   Rubio-Perez, Ines
   Morales-Perez, Carlos
   Bueno-Lledo, Jose
   Rodriguez-Lorenzo, Laura M.
   Sancho, Joan
   Marin-Pena, Oliver
   Lopez, Susana
   Masia, Jaume
   Balibrea, Jose M.
TI Closed-Incision Negative Pressure Therapy: Scoping Review and
   Multidisciplinary Consensus Recommendations of the Spanish Observatory
   of Infection in Surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE consensus recommendation; negative-pressure wound therapy;
   seroma/prevention and control*; surgical wound infection/epidemiology;
   surgical wound*/complications; wound healing
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; CHARLSON COMORBIDITY
   INDEX; WOUND THERAPY; COMPLICATIONS; METAANALYSIS; PREVENTION; EFFICACY;
   IMPACT; COSTS
AB Surgical site infections (SSI) and surgical site complications (SSC) significantly impact surgery outcomes, increasing hospital stays and mortality rates, and negatively affecting patients' quality of life. Closed-incision negative pressure therapy (ciNPT) emerged as a prophylactic strategy to reduce these complications. However, its applicability across different surgical procedures remains unclear. A scoping review was conducted to synthesise the available evidence on the use of ciNPT in different surgical contexts. A multidisciplinary panel of experts from different surgical specialties was assembled to identify patient risk factors for SSCs specific to each modality. Surgical procedures were categorised based on anticipated SSC rates and the impact of SSI. A decision diagram was finally developed, providing tailored recommendations for ciNPT use according to individual surgical circumstances. The findings of the review indicate that ciNPT effectively reduces SSI and SSC in most surgical procedures. Key patient-related factors influencing outcomes, such as age, obesity, and malnutrition, were outlined. Additionally, a specialty-based list of surgical procedures was compiled, specifying whether ciNPT is recommended, not recommended, or conditionally recommended based on specific criteria. This study underscores the benefits of ciNPT and provides a comprehensive guide to its application across several surgical specialties, aiming to optimise patient management and inform clinical practise.
C1 [Badia, Josep M.] Hosp Gen Granollers, Dept Surg, Granollers, Spain.
   [Badia, Josep M.] Univ Int Catalunya, Barcelona, Spain.
   [Rubio-Perez, Ines] Hosp Univ La Paz, Dept Surg, Madrid, Spain.
   [Morales-Perez, Carlos] Cent Univ Hosp Asturias HUCA, Cardiac Surg Serv, Oviedo, Spain.
   [Bueno-Lledo, Jose] Hosp Univ & Politecn La Fe, Dept Surg, Unit Abdominal Wall, Valencia, Spain.
   [Bueno-Lledo, Jose] Univ Valencia, Valencia, Spain.
   [Rodriguez-Lorenzo, Laura M.] Hosp Univ Parc Tauli, Dept Vasc Surg, Sabadell, Spain.
   [Sancho, Joan] Hosp Mar, Dept Surg, Barcelona, Spain.
   [Marin-Pena, Oliver] Hosp Univ Infanta Leonor, Dept Orthoped Surg & Traumatol, Madrid, Spain.
   [Lopez, Susana; Masia, Jaume] Hosp Univ St Pau, Dept Plast Surg, Barcelona, Spain.
   [Balibrea, Jose M.] Hosp Univ Germans Trias, Dept Surg, Endocrine Metab & Bariatr Surg Unit, Badalona, Spain.
   [Balibrea, Jose M.] Univ Autonoma Barcelona, Barcelona, Spain.
C3 Universitat Internacional de Catalunya (UIC); Hospital Universitario La
   Paz; Central University Hospital Asturias; Hospital Universitari i
   Politecnic La Fe; University of Valencia; Autonomous University of
   Barcelona; Parc Tauli Hospital Universitari; Hospital del Mar Research
   Institute; Hospital del Mar; Hospital Universitario Infanta Leonor;
   Hospital Germans Trias i Pujol; Autonomous University of Barcelona
RP Badia, JM (通讯作者)，Hosp Gen Granollers, Dept Surg, Granollers, Spain.; Badia, JM (通讯作者)，Univ Int Catalunya, Barcelona, Spain.
EM jmbadiaperez@gmail.com
RI ; Bueno-Lledó, Jose/I-2674-2019; MARIN-PEÑA, OLIVER/I-6265-2019;
   Balibrea, José M/V-5007-2019; Badia, Josep M/IVV-5872-2023
OI ROIGUEZ LORENZO, LAURA/0000-0003-2977-4627; Masia,
   Jaume/0000-0003-0141-9586; Bueno-Lledó, Jose/0000-0002-3116-5022;
   MARIN-PEÑA, OLIVER/0000-0002-7814-5766; Balibrea, José
   M/0000-0002-0764-7179; Badia, Josep M/0000-0003-2928-5233; Rubio-Perez,
   Ines/0000-0002-3960-6865
FU Smith+Nephew
FX Writing/editorial support was funded by Smith+Nephew, which also
   provided the funding for the travel and accommodation of the panellists
   during the meetings. Smith+Nephew market the PICO Single-use Negative
   Pressure Wound Therapy System. The funding source had no role in the
   study design, data analysis, data interpretation, expert conclusions and
   recommendations, or report writing. All authors submitted disclosure
   statements in accor-dance with JMI guidelines and format
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NR 133
TC 3
Z9 3
U1 3
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT 6
PY 2025
VL 22
IS 10
AR e70750
DI 10.1111/iwj.70750
PG 15
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA E9454
UT WOS:001623047000001
PM 41054272
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Polomska, K
   Kowalik, J
   Kobiela, J
   Spychalski, P
AF Polomska, Katarzyna
   Kowalik, Janina
   Kobiela, Jarek
   Spychalski, Piotr
TI Effectiveness of Open Incision Negative Pressure Wound Therapy for
   Surgical Site Infection Prevention for Abdominal Surgery-A Systematic
   Review and Meta-Analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE general surgery; negative pressure wound therapy; surgical wound;
   surgical wound infection
ID RANDOMIZED CONTROLLED-TRIAL; CLOSURE
AB Open incision negative pressure wound therapy (NPWT) combines delayed closure with negative pressure to prevent surgical site infection (SSI). Its effectiveness in preventing SSI remains unclear, complicating its risk-benefit assessment. PubMed and Web of Science databases were searched for relevant English studies. Two reviewers independently screened titles and abstracts using the ASReviewer tool. Full-text articles were assessed for eligibility. Eight studies were included in the systematic review and five were pooled in the meta-analysis. Data extraction followed the PRISMA guidelines, and the risk of bias was assessed. A meta-analysis was performed using a random-effects model for SSI occurrence. Eight studies (three RCTs and five cohort studies) with 1655 patients were included. Studies were pooled based on control interventions: primary closure (PC) or delayed primary closure (DPC). Pooled odds ratio (OR) estimates favoured NPWT over PC for SSI reduction (OR, 0.15; 95% CI, 0.02-0.87). No significant SSI risk difference was found between the NPWT and DPC groups (OR, 0.28; 95% CI, 0.06-1.27). Preventive NPWT is associated with a reduced risk of SSI in abdominal surgery compared to PC. Our findings indicate that standardising treatment and reporting protocols could improve future evaluations of NPWT effectiveness.Trial Registration: PROSPERO identifier: CRD42024401669
C1 [Polomska, Katarzyna; Kowalik, Janina; Kobiela, Jarek; Spychalski, Piotr] Med Univ Gdansk, Dept Oncol Transplant & Gen Surg, Gdansk, Poland.
C3 Fahrenheit Universities; Medical University Gdansk
RP Spychalski, P (通讯作者)，Med Univ Gdansk, Dept Oncol Transplant & Gen Surg, Gdansk, Poland.
EM piotr.spychalski@gumed.edu.pl
RI ; Spychalski, Piotr/KIG-0774-2024
OI Połomska, Katarzyna/0009-0005-1719-1215; 
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NR 31
TC 5
Z9 5
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2025
VL 22
IS 4
AR e70199
DI 10.1111/iwj.70199
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA E9828
UT WOS:001623084500001
PM 40234096
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Morais, LPF
   Moore, ZEH
   Patton, D
   Connor, TO
   Wilson, HJE
AF Morais, Liliana Patricia Ferreira
   Moore, Zena Elizabeth Helen
   Patton, Declan
   Connor, Tom O'
   Wilson, Hannah Jane Elizabeth
TI What is the Impact of Negative Pressure Wound Therapy on Healing in
   Patients Post Excision of Pilonidal Sinus? A Systematic Review and
   Meta-Analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE negative pressure wound therapy; NPWT; pilonidal cyst; pilonidal sinus;
   systematic review
ID SURGERY; DISEASE
AB This systematic review aimed to determine the impact of negative pressure wound therapy on healing in patients with pilonidal sinus following surgical excision. Using systematic review methodology, we included original research studies written in English. The search was conducted using CINAHL Plus, Ovid, PubMed, EBSCO Host and Cochrane databases. Quality appraisal was undertaken using the Cochrane Collaboration tool for assessing risk of bias and the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Data were analysed using meta-analysis where appropriate; otherwise, the data are presented narratively. Ten studies were included with a mean sample size of 61 (SD: 33). Three studies were randomised control trials, four were retrospective studies, two were prospective cohort studies and one was pre-post study. Studies showed reduction in healing time, recurrence rates and postoperative pain, as well as higher patients' satisfaction with the use negative pressure wound therapy, however, the certainty of the evidence was very low. The evidence for the intervention is uncertain thus, it is unclear whether NPWT makes any difference when compared to any other dressings, on time to healing, recurrence, pain or patient's experience. Further high-quality research with larger sample sizes is recommended to clearly explore the impact of NPWT on PS healing, recurrence, pain and patient's satisfaction.
C1 [Morais, Liliana Patricia Ferreira; Moore, Zena Elizabeth Helen; Patton, Declan; Connor, Tom O'; Wilson, Hannah Jane Elizabeth] Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dublin, Ireland.
   [Morais, Liliana Patricia Ferreira; Moore, Zena Elizabeth Helen; Patton, Declan; Connor, Tom O'; Wilson, Hannah Jane Elizabeth] RCSI Univ Med & Hlth Sci, Sch Nursing & Midwifery, Dublin, Ireland.
   [Moore, Zena Elizabeth Helen; Patton, Declan; Connor, Tom O'; Wilson, Hannah Jane Elizabeth] RCSI Univ Med & Hlth Sci, Skin Wounds & Trauma Res Ctr, Dublin, Ireland.
   [Moore, Zena Elizabeth Helen; Patton, Declan; Connor, Tom O'] Fakeeh Coll Med Sci, Jeddah, Saudi Arabia.
   [Moore, Zena Elizabeth Helen; Connor, Tom O'] Griffith Univ, Sch Nursing & Midwifery, Brisbane, Qld, Australia.
   [Moore, Zena Elizabeth Helen; Connor, Tom O'] Lida Inst, Shanghai, Peoples R China.
   [Moore, Zena Elizabeth Helen] Monash Univ, Fac Med Nursing & Hlth Sci, Melbourne, Vic, Australia.
   [Moore, Zena Elizabeth Helen] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth, Shanghai, Peoples R China.
   [Moore, Zena Elizabeth Helen] Univ Wales Coll Cardiff, Cardiff, Wales.
   [Moore, Zena Elizabeth Helen] Natl Hlth & Med Res Council Ctr Res Excellence Wis, Menzies Hlth Inst Queensland, Brisbane, Qld, Australia.
   [Patton, Declan] Univ Wollongong, Fac Sci Med & Hlth, Wollongong, NSW, Australia.
C3 Royal College of Surgeons in Ireland - RCSI; Royal College of Surgeons
   in Ireland - RCSI; Royal College of Surgeons in Ireland - RCSI; Fakeeh
   College for Medical Sciences; Griffith University; Monash University;
   Ghent University; Cardiff University; Menzies Health Institute
   Queensland; University of Wollongong
RP Morais, LPF (通讯作者)，Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dublin, Ireland.; Morais, LPF (通讯作者)，RCSI Univ Med & Hlth Sci, Sch Nursing & Midwifery, Dublin, Ireland.
EM lilianamorais21@rcsi.com; zmoore@rcsi.com; declanpatton@rcsi.com;
   tomoconnor@rcsi.ie; wilsonhannah@rcsi.com
OI Patricia Ferreira Morais, Liliana/0009-0007-8750-9393
CR El-Tohfa YAY, 2020, Al-Azhar Medical Journal, V49, P1303, DOI 10.21608/amj.2020.107126
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NR 40
TC 2
Z9 2
U1 2
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2025
VL 22
IS 5
AR e70194
DI 10.1111/iwj.70194
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F0169
UT WOS:001623118600001
PM 40288765
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Nuutila, K
   Diaz, V
   Anselmo, K
   Broomhead, M
   Eriksson, E
   Chan, RK
AF Nuutila, Kristo
   Diaz, Victoria
   Anselmo, Kristin
   Broomhead, Michael
   Eriksson, Elof
   Chan, Rodney K.
TI A Prospective, Controlled, Randomised, Clinical Study of Negative
   Pressure Device Without Foam or Gauze for Skin and Soft Tissue Defects
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE clinical trial; negative pressure platform wound device (NP-PWD);
   negative pressure wound therapy; NPWT; wound healing
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY
AB All common negative pressure wound therapy (NPWT) systems include a filler material usually foam or gauze at the wound/device interface. The filler material distributes the negative pressure evenly to all parts of the wound. The foam or gauze may fragment contributing to foreign material being retained in the wound, becoming colonised with bacteria over time, and painful dressing changes. To mitigate these, negative aspects, an impermeable embossed single-layer NPWT membrane dressing has been developed. The dressing has been coined Negative Pressure-Platform Wound Device (NP-PWD) and a foam or gauze is not required to deliver negative pressure. Rather, the pressure is permeated via the spaces between the embossed pyramids and the wrinkles in the membrane. The purpose of this study was to compare the NP-PWD to the standard of care (SOC) NPWT system in the treatment of skin and soft tissue defects. This was a prospective, randomised, controlled clinical trial. The wounds were treated with the NP-PWD or SOC NPWT system. The randomised treatment was applied for 2 days to up to 9 days after the initial application. Follow-up data were collected at each dressing change/removal and included photographs, and assessments for wound healing, infection, and adverse events. In total 24 subjects (12 NP-PWD and 12 SOC) completed the study. The NP-PWD was easy to use and fast to apply and the patients tolerated it well. The transparency of the NP-PWD allowed the provider to see the wound without removing the dressing which is an improvement over traditional NPWT. In terms of wound healing, inflammation, pain, and infection, no differences were observed between the NP-PWD and the SOC NPWT system. The NP-PWD is a simplified, single component NPWT system eliminating the use of the filler material that commonly causes challenges during treatment.
C1 [Nuutila, Kristo] United States Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Diaz, Victoria; Anselmo, Kristin; Chan, Rodney K.] Metis Fdn, San Antonio, TX 78216 USA.
   [Broomhead, Michael; Eriksson, Elof] Appl Tissue Technol LLC, Hingham, MA USA.
RP Nuutila, K (通讯作者)，United States Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.; Chan, RK (通讯作者)，Metis Fdn, San Antonio, TX 78216 USA.
EM kristo.nuutila@gmail.com; rodneykchan@gmail.com
FU Applied Tissue Technologies LLC
FX The authors have nothing to report.
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NR 36
TC 3
Z9 3
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2025
VL 22
IS 5
AR e70144
DI 10.1111/iwj.70144
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F0196
UT WOS:001623121300001
PM 40320611
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Singh, D
   Alton, T
   Alvand, A
   de Toledo, PRB
   Chatterjee, A
   Dillavou, E
   Djohan, R
   Ortega, AVG
   Pieri, A
   Sumpio, B
   Willy, C
   Zelle, B
   Cooper, HJ
AF Singh, Devinder
   Alton, Timothy
   Alvand, Abtin
   Barbosa de Toledo, Paulo Roberto
   Chatterjee, Abhishek
   Dillavou, Ellen
   Djohan, Risal
   Ortega, Alba Viviana Gomez
   Pieri, Andrew
   Sumpio, Bauer
   Willy, Christian
   Zelle, Boris
   Cooper, H. John
TI Linear and Area Coverage With Closed Incision Negative Pressure Therapy
   Management: International Multidisciplinary Consensus Recommendations
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE expert opinion; negative pressure wound therapy; risk factors; surgical
   wound; wound healing
ID SURGICAL-SITE INFECTION; WOUND THERAPY; KNEE ARTHROPLASTY; HIP;
   COMPLICATIONS; SURGERY; DRESSINGS; PREVENTION; WOMEN
AB Closed incision negative pressure therapy (ciNPT) with foam dressings has received broad recognition for its ability to support incision healing for a variety of surgical procedures. Over time, these dressings have evolved to include linear and 'area' shapes to better conform to different incision types and surface geometries. To address new studies on these configurations and provide guidance for dressing selection, an international, multidisciplinary panel of experts was convened. The panel reviewed recent publications on ciNPT with reticulated open cell foam (ROCF) dressings, shared their cases and experiences and engaged in roundtable discussions on benefits, drawbacks and technical challenges. Topics were ranked by importance and refined into potential consensus statements. These were shared for anonymous feedback, requiring 80% agreement for consensus. This manuscript establishes 12 consensus statements regarding risk factors supporting the use of ciNPT, conditions supporting preference of linear or area ciNPT dressings and tips for practical application of ciNPT with ROCF dressings. While this consensus panel expands on previous publications to aid clinicians' decision-making, further research is needed to refine recommendations and identify the strengths and limitations of ciNPT. Continued multidisciplinary collaboration will ensure ciNPT remains vital for improving surgical outcomes and patient care.
C1 [Singh, Devinder] Univ Miami, Miller Sch Med, Dept Surg, Miami, FL USA.
   [Alton, Timothy] Proliance Orthopaed Associates, Renton, WA USA.
   [Alvand, Abtin] Oxford Univ Hosp NHS Trust, Nuffield Orthopaed Ctr, Oxford, England.
   [Barbosa de Toledo, Paulo Roberto] Hosp Quinta Dor, Dept Orthoped Trauma, Rio De Janeiro, Brazil.
   [Chatterjee, Abhishek] Tufts Med Ctr, Dept Surg, Boston, MA USA.
   [Dillavou, Ellen] WakeMed Hosp Syst, Dept Vasc Surg, Raleigh, NC USA.
   [Djohan, Risal] Cleveland Clin, Dermatol & Plast Surg Inst, Dept Plast Surg, Cleveland, OH USA.
   [Ortega, Alba Viviana Gomez] Fdn Santa Fe Bogota, Bogota, Colombia.
   [Pieri, Andrew] Royal Victoria Infirm, Newcastle Upon Tyne, England.
   [Sumpio, Bauer] Yale Univ, Sch Med, Dept Surg, New Haven, CT USA.
   [Willy, Christian] Mil Acad Hosp Berlin, Dept Surg, Berlin, Germany.
   [Zelle, Boris] Univ Texas Hlth San Antonio, Dept Orthopaed, San Antonio, TX USA.
   [Cooper, H. John] Colombia Univ, Dept Orthoped Surg, New York, NY USA.
C3 University of Miami; Nuffield Orthopaedic Centre; Oxford University
   Hospitals NHS Foundation Trust; Tufts Medical Center; Cleveland Clinic
   Foundation; Newcastle University - UK; Yale University; University of
   Texas System; University of Texas at San Antonio
RP Singh, D (通讯作者)，Univ Miami, Miller Sch Med, Dept Surg, Miami, FL USA.
EM dsingh.md@gmail.com
RI Cooper, H./H-3488-2019
FU Solventum Corporation (Maplewood, MN)
FX Funding for the advisory panel meeting was provided by Solventum
   Corporation (Maplewood, MN).
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   Ponce Oscar J, 2017, Evid Based Med, V22, P164, DOI 10.1136/ebmed-2017-110798
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   Renno I, 2019, CLIN HEMORHEOL MICRO, V72, P139, DOI 10.3233/CH-180450
   Salem HS, 2022, J KNEE SURG, V35, P1023, DOI 10.1055/s-0041-1740394
   Saunders R, 2023, J HEALTH ECON OUTCOM, V10, P132, DOI [10.36469/jheor.2023.90651, 10.36469/001c.90651]
   Shahian DM, 2018, ANN THORAC SURG, V105, P1411, DOI 10.1016/j.athoracsur.2018.03.002
   Sibia US, 2022, PLAST SURG-CHIR PLAS, V30, P325, DOI 10.1177/22925503211019628
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   Silverman RP, 2022, INT WOUND J, V19, P643, DOI 10.1111/iwj.13662
   Singh DP, 2019, PLAST RECONSTR SURG, V143, p41S, DOI 10.1097/PRS.0000000000005312
   Song JY, 2023, INT WOUND J, V20, P241, DOI 10.1111/iwj.13866
   Suh H, 2016, ANN PLAS SURG, V76, P717, DOI 10.1097/SAP.0000000000000231
   Tuuli MG, 2020, JAMA-J AM MED ASSOC, V324, P1180, DOI 10.1001/jama.2020.13361
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   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
   World Health Organization, "Global Guidelines for the Prevention of Surgical Site Infection,"
   Zelle BA, 2022, J ORTHOP TRAUMA, V36, pS31, DOI 10.1097/BOT.0000000000002427
NR 63
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2025
VL 22
IS 6
AR e70677
DI 10.1111/iwj.70677
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F0227
UT WOS:001623124400001
PM 40432310
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ohura, N
   Sakisaka, M
   Nakayama, D
   Kinoshita, M
AF Ohura, Norihiko
   Sakisaka, Masanobu
   Nakayama, Daisuke
   Kinoshita, Mikio
TI Investigation of Optimal Parameters Setting for Negative Pressure Wound
   Therapy With Instillation and Dwell Time for Hard-To-Heal Wounds With
   Necrotic Tissue
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure wound therapy; negative pressure wound therapy with
   instillation and dwelling; NPWT; NPWTi-d; wound healing time
AB Negative Pressure Wound Therapy (NPWT) is a standard treatment for chronic wounds. In 2017, NPWT with instillation and dwell time (NPWTi-d) was approved for insurance coverage in Japan. This study aimed to identify optimal NPWTi-d parameter settings for hard-to-heal wounds with necrotic tissue. We conducted a retrospective observational study of consecutive patients treated with NPWTi-d between August 2017 and February 2019. Parameters analyzed included dressing change frequency (three times per week vs. once per week), therapy duration (2, 3, or 3.5 h), negative pressure levels (50-125 mmHg), dwell time (1-10 min), and instillation volume (mL/cm3 of foam). Fifty-six patients were included. Among the 52 patients managed with once-weekly dressing changes, five developed infections. A dwell time of >= 5 min significantly shortened the median treatment period to 11 days, compared to 26 days in those with shorter dwell times. NPWTi-d is more effective when treatment parameters are optimized. A dwell time over 5 min and once-per-week dressing replacement are sufficient, reducing both patient burden and healthcare provider workload. These findings provide evidence-based guidance for the efficient clinical use of NPWTi-d.
C1 [Ohura, Norihiko; Sakisaka, Masanobu; Nakayama, Daisuke; Kinoshita, Mikio] Kyorin Univ, Sch Med, Dept Plast Surg, Tokyo, Japan.
C3 Kyorin University
RP Ohura, N (通讯作者)，Kyorin Univ, Sch Med, Dept Plast Surg, Tokyo, Japan.
EM norihiko.ohura@gmail.com
FU Solventum
FX The article processing charge (APC) was supported by Solventum.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bassetto F., 2021, Wounds
   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUL
PY 2025
VL 22
IS 7
AR e70716
DI 10.1111/iwj.70716
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F0262
UT WOS:001623127900001
PM 40583284
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Herczeg, A
   Szijárto, A
   Fülöp, A
   Varga, K
   Marton, J
   Loderer, Z
   Mohos, B
   Páncél, B
   Szendrényi, V
   Lázár, G
   Libor, L
   Káposztás, Z
   Máthé, E
   Bursics, A
   Kecskédi, B
   Sikorszki, L
   Venczel, L
   Bánky, B
AF Herczeg, Andras
   Szijarto, Attila
   Fulop, Andras
   Varga, Krisztina
   Marton, Jozsef
   Loderer, Zoltan
   Mohos, Balazs
   Pancel, Balazs
   Szendrenyi, Vilmos
   Lazar, Gyorgy
   Libor, Laszlo
   Kaposztas, Zsolt
   Mathe, Ervin
   Bursics, Attila
   Kecskedi, Bence
   Sikorszki, Laszlo
   Venczel, Laszlo
   Banky, Balazs
TI Prophylactic Negative Pressure Wound Therapy Reduces Superficial
   Surgical Site Infection Risk of Emergency Surgery Patients: Results of a
   Multicenter Randomised Prospective Clinical Trial
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE emergency surgery; negative pressure wound therapy; prevention; surgical
   site infection
ID PREVENTION; CLOSURE; COMPLICATIONS; LAPAROTOMIES
AB Despite modern aseptic precautions, surgical site infection remains a significant problem. Although the benefits of negative pressure wound therapy in the treatment of chronic wounds are well established, high-level evidence is still lacking on the potential role of negative pressure in the prevention of surgical site infections. We conducted a multicenter, randomised, prospective trial of closed incision vacuum therapy. A total of 90 general surgery patients undergoing emergency laparotomy were enrolled and randomised, 45 cases in the treatment group and 45 cases in the control group. Our aim was to show a significant difference in the rate of surgical site infection between the two groups. In the study group, laparotomy wounds were treated with a single 5-day course of prophylactic vacuum therapy, whereas the control group underwent conventional postoperative wound management with sterile gauze dressings. Ten of the 45 patients in the study group developed a surgical site infection compared to 20 of 45 in the control group (22.2% vs. 44.4% p = 0.025). Upon further analysis, the proportion of superficial SSIs was found to be significantly lower in the ciNPWT group (40% vs. 20% p = 0.038), whereas the difference in deep SSI rates was not statistically significant (4.4% vs. 4.4% p = 1.0). In conclusion, negative pressure wound therapy is not only an effective way to heal chronic wounds, but it's prophylactic use may reduce the overall rate of surgical site infections.Trial Registration: : NCT03716687
C1 [Herczeg, Andras; Szijarto, Attila; Fulop, Andras; Varga, Krisztina; Banky, Balazs] Semmelweis Univ, Dept Surg Transplantat & Gastroenterol, Budapest, Hungary.
   [Varga, Krisztina; Marton, Jozsef; Banky, Balazs] St Borbala Hosp, Dept Surg, Tatabanya, Hungary.
   [Loderer, Zoltan; Mohos, Balazs] Markusovszky Univ Teaching Hosp Vas Cty, Dept Surg, Szombathely, Hungary.
   [Pancel, Balazs; Szendrenyi, Vilmos] St Rokus Hosp, Dept Surg, Baja, Hungary.
   [Lazar, Gyorgy; Libor, Laszlo] Univ Szeged, Surg Clin, Szeged, Hungary.
   [Kaposztas, Zsolt; Mathe, Ervin] Kap Mor Hosp Somogy Cty, Kaposvar, Hungary.
   [Bursics, Attila; Kecskedi, Bence] Uzsoki St Hosp, Dept Surg, Budapest, Hungary.
   [Sikorszki, Laszlo; Venczel, Laszlo] Hosp Bacs Kiskun Cty, Dept Surg, Kecskemet, Hungary.
C3 Semmelweis University; Szeged University
RP Herczeg, A (通讯作者)，Semmelweis Univ, Dept Surg Transplantat & Gastroenterol, Budapest, Hungary.
EM herczeg.andras.ivan@semmelweis.hu
RI /AAL-9676-2020
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Avsar P, 2021, WOUND MANAG PREV, V67, DOI 10.25270/wmp.2021.6.1019
   Banasiewicz T., "Traditional and Single Use NPWT: When to Use and How to Decide on the Appropriate Use? Recommendations of an Expert Panel,"
   Banky B., "Prophylactic ciNPWT for High-Risk Laparotomy Wounds. Preliminary Results of a Multi-Centre Randomised Controlled Trial
   Berríos SI, 2017, JAMA SURG, V152, P784, DOI 10.1001/jamasurg.2017.0904
   Boland PA, 2021, IRISH J MED SCI, V190, P261, DOI 10.1007/s11845-020-02283-7
   Cheadle William G, 2006, Surg Infect (Larchmt), V7 Suppl 1, pS7, DOI 10.1089/sur.2006.7.s-7
   Gao JR, 2021, J ADV NURS, V77, P3980, DOI 10.1111/jan.14876
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   Irwin GW, 2020, PRS-GLOB OPEN, V8, DOI 10.1097/GOX.0000000000002667
   Karlakki SL, 2016, BONE JOINT RES, V5, P328, DOI 10.1302/2046-3758.58.BJR-2016-0022.R1
   Lakhani A, 2022, SURGERY, V172, P949, DOI 10.1016/j.surg.2022.05.020
   Matatov T, 2013, J VASC SURG, V57, P791, DOI 10.1016/j.jvs.2012.09.037
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   Papadopoulos A, 2021, IN VIVO, V35, P3569, DOI 10.21873/invivo.12660
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   Seidelman JL, 2023, JAMA-J AM MED ASSOC, V329, P244, DOI 10.1001/jama.2022.24075
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NR 25
TC 5
Z9 5
U1 4
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUL
PY 2025
VL 22
IS 7
AR e70718
DI 10.1111/iwj.70718
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F0267
UT WOS:001623128400001
PM 40605477
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Nicolosi, B
   Curcio, F
   Maffeo, M
   Di Leva, M
   Gregorini, M
   Buccione, E
   Coletta, R
AF Nicolosi, Biagio
   Curcio, Felice
   Maffeo, Marina
   Di Leva, Marika
   Gregorini, Mirco
   Buccione, Emanuele
   Coletta, Riccardo
TI Early Use of Incisional Negative Pressure Wound Therapy in Pediatric
   Abdominal and Thoracic Surgery: A Single-Center Retrospective Study on
   Clinical and Economic Outcomes
SO CHILDREN-BASEL
LA English
DT Article
DE negative pressure wound therapy; pediatric surgery; surgical wound
   complications; wound healing; economic outcomes; incisional NPWT
ID INFECTIONS; CHILDREN
AB Aim: To evaluate the effectiveness and economic impact of early Incisional Negative Pressure Wound Therapy (iNPWT) in promoting surgical wound healing in pediatric patients undergoing abdominal and thoracic surgery. Background: Surgical wound complications, such as dehiscence and infection, are frequent in pediatric patients, especially in high-risk cases. Although iNPWT is increasingly used in surgical care, evidence supporting its efficacy in pediatric populations remains limited. Methods: This single-center, retrospective observational study analyzed 49 pediatric patients who underwent abdominal or thoracic surgery between January and December 2023. Patients received either intraoperative iNPWT (early application) or standard dressings. The outcomes assessed included time to complete wound healing, incidence of complications, pain levels, and healthcare costs. Results: Patients treated with early iNPWT showed significantly faster wound healing and fewer complications-particularly dehiscence and infections-compared to those receiving standard dressing. Pain perception did not significantly differ between groups. Although the initial costs of iNPWT were higher, overall costs were lower due to fewer complications and shorter hospital stays. Conclusions: Early iNPWT is a clinically effective and cost-efficient intervention for pediatric surgical patients at high risk of wound complications. However, limitations related to the retrospective design and small sample size suggest that prospective multicenter studies are needed to confirm these findings and support the development of standardized pediatric protocols.
C1 [Nicolosi, Biagio; Gregorini, Mirco] Meyer Childrens Hosp IRCCS, Healthcare Profess Dept, I-50139 Florence, Italy.
   [Curcio, Felice] Univ Hosp Sassari, Pediat & Neonatal Surg, I-07100 Sassari, Italy.
   [Maffeo, Marina] Meyer Childrens Hosp IRCCS, Pediat Intens Care Unit, I-50139 Florence, Italy.
   [Di Leva, Marika] Univ Florence, Sch Human Hlth Sci, I-50139 Florence, Italy.
   [Buccione, Emanuele] Hlth Local Author Pescara, Pediat Intens Care Unit, I-65124 Pescara, Italy.
   [Coletta, Riccardo] Meyer Childrens Hosp IRCCS, Dept NEUROFARBA, I-50139 Florence, Italy.
C3 University of Sassari; University of Florence
RP Nicolosi, B (通讯作者)，Meyer Childrens Hosp IRCCS, Healthcare Profess Dept, I-50139 Florence, Italy.
EM biagio.nicolosi@meyer.it; felice.curcio@aousassari.it;
   marina.maffeo@meyer.it; emanuele.buccione@asl.pe.it
RI Coletta, Riccardo/AAB-2022-2019; Nicolosi, Biagio/NJS-0720-2025; Curcio,
   Felice/MFK-0726-2025; Buccione, Emanuele/GOJ-9965-2022; , Marina
   Maffeo/LXU-9158-2024
OI Nicolosi, Biagio/0009-0008-6665-1638; Curcio,
   Felice/0000-0001-5759-1065; Buccione, Emanuele/0000-0003-4146-8948; ,
   Marina Maffeo/0009-0004-4155-4381; Di Leva, Marika/0009-0003-7495-531X
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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   Badin D, 2022, J PEDIATR ORTHOPED, V42, pE1008, DOI 10.1097/BPO.0000000000002255
   Baharestani M, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00607.x
   Catania VD, 2019, FRONT PEDIATR, V7, DOI 10.3389/fped.2019.00101
   Cohen J., 2013, SECURITY CONSTITUTIO, P58, DOI 10.4324/9780203771587
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   Gupta S, 2017, WOUNDS, pS19
   Hummel P, 2008, J PERINATOL, V28, P55, DOI 10.1038/sj.jp.7211861
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   Santosa KB, 2019, J SURG RES, V235, P560, DOI 10.1016/j.jss.2018.10.043
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NR 23
TC 1
Z9 1
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD OCT 23
PY 2025
VL 12
IS 11
AR 1433
DI 10.3390/children12111433
PG 11
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA F4552
UT WOS:001623558700001
PM 41300551
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Garayua-Cruz, L
   Broida, SE
   Sullivan, MH
   Folpe, AL
   Welliver, MX
   Lee, KN
   Siontis, BL
   Robinson, SI
   Ho, TP
   Okuno, SH
   Rose, PS
   Bakri, K
   Moran, SL
   Houdek, MT
AF Garayua-Cruz, Leilani
   Broida, Samuel E.
   Sullivan, Mikaela H.
   Folpe, Andrew L.
   Welliver, Meng X.
   Lee, Katie N.
   Siontis, Brittany L.
   Robinson, Steven I.
   Ho, Thanh P.
   Okuno, Scott H.
   Rose, Peter S.
   Bakri, Karim
   Moran, Steven L.
   Houdek, Matthew T.
TI Staged Reconstruction Is Not Necessary Following Oncologic Resection of
   Superficial Myxofibrosarcoma
SO CANCERS
LA English
DT Article
DE myxofibrosarcoma; VAC therapy; recurrence; staged reconstruction
ID EXPERIENCE; EXTREMITY
AB Background: Myxofibrosarcomas are notoriously highly infiltrative soft-tissue sarcomas, making negative surgical margins difficult to obtain. Recently, vacuum-assisted closure (VAC) is used to delay wound closure until a negative margin has been achieved; however, this can delay care and increase costs. Our institution has historically performed single-stage resections with intraoperative frozen margin analysis and reconstruction in these patients. The purpose of this study is to report the outcomes of this technique. Methods: We reviewed 112 patients (62 males, mean age 70 +/- 14 years) with superficial myxofibrosarcoma. Eighty-eight patients received preoperative radiation. All patients underwent surgical resection with intraoperative frozen margin analysis, and the planned reconstruction was performed in a single anesthetic. Results: The 10-year local recurrence-free survival was 90%; positive intraoperative frozen section (HR 7.44, p = 0.004) and final permanent margins (HR 8.53, p = 0.007) were associated with local recurrence. Intraoperative margins were negative in 103 (92%) of patients, 1 of which was positive on final permanent section. There were nine cases of microscopically positive margins, of which seven underwent immediate re-excision to a negative margin. The accuracy of frozen margin assessment for myxofibrosarcoma was between 92.92 and 98.23%. All patients underwent reconstruction at the time of resection, with 19% needing an additional procedure, most commonly due to a wound complication (12%). Conclusions: Multidisciplinary single-stage excision with intraoperative frozen margin assessment and soft-tissue reconstruction yields low rates of local recurrence in patients with superficial myxofibrosarcoma.
C1 [Garayua-Cruz, Leilani] Univ Puerto Rico, Sch Med, San Juan, PR 00936 USA.
   [Broida, Samuel E.; Sullivan, Mikaela H.; Rose, Peter S.; Houdek, Matthew T.] Mayo Clin, Dept Orthoped Surg, Rochester, MN 55905 USA.
   [Folpe, Andrew L.] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
   [Welliver, Meng X.; Lee, Katie N.] Mayo Clin, Dept Radiat Oncol, Rochester, MN 55905 USA.
   [Siontis, Brittany L.; Robinson, Steven I.; Ho, Thanh P.; Okuno, Scott H.] Mayo Clin, Dept Med Oncol, Rochester, MN 55905 USA.
   [Bakri, Karim; Moran, Steven L.] Mayo Clin, Div Plast & Reconstruct Surg, Rochester, MN 55905 USA.
C3 University of Puerto Rico; University of Puerto Rico Medical Sciences
   Campus; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Houdek, MT (通讯作者)，Mayo Clin, Dept Orthoped Surg, Rochester, MN 55905 USA.
EM houdek.matthew@mayo.edu
RI Houdek, Matthew/AGK-3443-2022; Moran, Steven/MZS-1312-2025
OI Houdek, Matthew/0000-0003-0390-1018; Broida, Samuel/0000-0002-4192-4133;
   Welliver, Meng/0000-0002-8747-692X; 
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NR 26
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD NOV 12
PY 2025
VL 17
IS 22
AR 3637
DI 10.3390/cancers17223637
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA F4762
UT WOS:001623579700001
PM 41301004
OA gold
DA 2026-07-24
ER
PT J
AU Villalba-Aguilar, C
   Laredo-Aguilera, JA
   Villalba-Aguilar, L
   Castillo-Hermoso, MI
   Lopez-Fernández-Roldán, A
   Carmona-Torres, JM
AF Villalba-Aguilar, Celia
   Laredo-Aguilera, Jose Alberto
   Villalba-Aguilar, Lucia
   Castillo-Hermoso, Matilde Isabel
   Lopez-Fernandez-Roldan, Angel
   Carmona-Torres, Juan Manuel
TI Comparative Efficacy of Negative Pressure Wound Therapy and Conventional
   Treatments in the Management of Diabetic Foot Ulcers: A Systematic
   Review and Meta-Analysis
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE diabetic foot ulcer; negative pressure therapy; wound healing;
   granulation tissue; clinical efficacy
ID VACUUM-ASSISTED CLOSURE; COST-EFFECTIVENESS; RANDOMIZED-TRIAL;
   MULTICENTER; SAFETY; CARE
AB Background: Diabetic foot syndrome is a common complication of diabetes mellitus, and its incidence is increasing due to increasing rates of overweight and an aging population. Negative pressure wound therapy has been shown to improve wound healing. This study aimed to analyze the efficacy of this therapy compared with conventional treatments in patients with diabetic foot ulcers. Methods: A systematic search was conducted in the following databases: PubMed, SCOPUS, CINAHL, and the Cochrane Library, and the methodological quality was assessed using the Rob2 scale. This meta-analysis was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: A total of 11 clinical trials involving 1117 subjects. The primary outcome was efficacy, which was measured by the complete healing rate, wound size, time to granulation tissue formation, adverse effects, amputations, hospital stay, and cost. This study demonstrated that this therapy improves healing (OR= -10.39, 95% CI [-14.22, -6.57]) and reduces wound size (OR = -4.11, 95% CI [-7.83, -0.39]) while potentially lowering overall costs. Conclusions: Limitations include heterogeneity and different variables measured in studies. Additionally, there were differences among the trials due to the lack of blinding. Although no significant differences were found in amputations or infections, this therapy reduces pain and decreases the use of antibiotics and analgesics. Its use requires individual and expert assessment to maximize its benefits.
C1 [Villalba-Aguilar, Celia] Hosp Laboral Solimat, Toledo 45004, Spain.
   [Villalba-Aguilar, Celia; Laredo-Aguilera, Jose Alberto; Castillo-Hermoso, Matilde Isabel; Lopez-Fernandez-Roldan, Angel; Carmona-Torres, Juan Manuel] Univ Castilla La Mancha, Fac Fisioterapia & Enfermeria, Toledo 45071, Spain.
   [Laredo-Aguilera, Jose Alberto; Carmona-Torres, Juan Manuel] Univ Castilla La Mancha, Grp Invest Multidisciplinar Cuidados IMCU, Toledo 45071, Spain.
   [Laredo-Aguilera, Jose Alberto; Carmona-Torres, Juan Manuel] Inst Invest Sanitaria Castilla La Mancha IDISCAM, Toledo 45004, Spain.
   [Villalba-Aguilar, Lucia] Univ Rey Juan Carlos, Fac Ciencias Salud, Alcorcon 28922, Spain.
   [Castillo-Hermoso, Matilde Isabel] Hosp Nacl Paraplej, Toledo 45004, Spain.
   [Lopez-Fernandez-Roldan, Angel] Hosp Univ Toledo, Toledo 45004, Spain.
C3 Universidad de Castilla-La Mancha; Universidad de Castilla-La Mancha;
   Universidad Rey Juan Carlos; Hospital Nacional de Paraplejicos
RP Laredo-Aguilera, JA (通讯作者)，Univ Castilla La Mancha, Fac Fisioterapia & Enfermeria, Toledo 45071, Spain.; Laredo-Aguilera, JA (通讯作者)，Univ Castilla La Mancha, Grp Invest Multidisciplinar Cuidados IMCU, Toledo 45071, Spain.; Laredo-Aguilera, JA (通讯作者)，Inst Invest Sanitaria Castilla La Mancha IDISCAM, Toledo 45004, Spain.
EM celia.villalbaa@hotmail.com; josealberto.laredo@uclm.es;
   luciavillalbaaguilar12@gmail.com; matildei.castillo@uclm.es;
   angel.lopezfernandez@uclm.es; juanmanuel.carmona@uclm.es
RI Castillo Hermoso, Matilde/LTF-0979-2024; CARMONA TORRES, JUAN
   MANUEL/E-1579-2018; López Fernández-Roldán, Ángel/OPO-0857-2025; Laredo
   Aguilera, José Alberto/ABR-3810-2022
OI Castillo Hermoso, Matilde/0009-0009-7947-6282; Villalba Aguilar,
   Celia/0009-0003-2766-224X; CARMONA TORRES, JUAN
   MANUEL/0000-0002-7781-872X; López Fernández-Roldán,
   Ángel/0009-0000-7285-0504; Laredo Aguilera, José
   Alberto/0000-0002-3661-3584
FU UCLM
FX Open Access funding enabled and organized by UCLM.
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NR 68
TC 2
Z9 2
U1 3
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV 13
PY 2025
VL 14
IS 22
AR 8051
DI 10.3390/jcm14228051
PG 24
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F9098
UT WOS:001624013300001
PM 41303087
OA gold
DA 2026-07-24
ER
PT J
AU Hou, SL
   Li, XW
   Chen, XS
   Yan, J
   Wang, BH
   Liu, CH
AF Hou, Shulin
   Li, Xiaowen
   Chen, Xushu
   Yan, Jing
   Wang, Bihua
   Liu, Chunhua
TI Application of Negative Pressure Wound Therapy in Neonatal Bone-Exposed
   Wounds: Nursing Interventions and Clinical Outcomes
SO NURSING IN CRITICAL CARE
LA English
DT Article
DE coccygectomy; negative pressure wound therapy; neonate; sacral bone
   exposure; Sacrococcygeal teratoma
ID SACROCOCCYGEAL TERATOMA; CHILDREN; CLOSURE
AB Sacrococcygeal teratoma (SCT) is the most common extragonadal germ cell tumor in neonates, with an incidence of approximately 1 in 35,000-40,000 live births. Postoperative management of SCT poses significant challenges due to the extensive surgical field and the anatomical proximity of the lesion to the perianal region. Altman type IV SCT, characterized by its entirely intrapelvic location and higher risk of malignancy, often requires radical resection in conjunction with coccygectomy. This procedure frequently results in deep tissue defects and exposes the sacral bone, increasing the risk of secondary infection. Conventional flap reconstruction is often impractical in neonates due to limited donor tissue availability, tissue fragility, and a high risk of complications. Negative Pressure Wound Therapy (NPWT) has demonstrated efficacy in promoting wound healing through multiple mechanisms, yet its application in neonatal wounds with exposed bone has not been previously reported. The aim of this case study is to summarise the experience of successfully treating postoperative SCT wounds complicated by sacral bone exposure using negative pressure wound therapy (NPWT) in combination with a sodium carboxymethylcellulose silver dressing (CMC-Ag). NPWT in combination with a sodium CMC-Ag. After 43 days of intensive treatment and care, the child recovered and was discharged. The insights gained from this case can provide valuable references for nursing practice in pediatric intensive care units. Relevance to Clinical Practice Offering a novel treatment strategy for this challenging clinical scenario.
C1 [Hou, Shulin; Li, Xiaowen; Chen, Xushu; Yan, Jing; Wang, Bihua; Liu, Chunhua] Sichuan Univ, West China Univ Hosp 2, Dept Neonatol Nursing, Chengdu, Peoples R China.
   [Hou, Shulin; Li, Xiaowen; Chen, Xushu; Yan, Jing; Wang, Bihua; Liu, Chunhua] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Peoples R China.
C3 Sichuan University; Sichuan University
RP Li, XW (通讯作者)，Sichuan Univ, West China Univ Hosp 2, Dept Neonatol Nursing, Chengdu, Peoples R China.; Li, XW (通讯作者)，Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Peoples R China.
EM xiaowenli@scu.edu.cn
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NR 27
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1362-1017
EI 1478-5153
J9 NURS CRIT CARE
JI Nurs. Crit. Care
PD NOV
PY 2025
VL 30
IS 6
AR e70250
DI 10.1111/nicc.70250
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA G2507
UT WOS:001624354200009
PM 41277281
DA 2026-07-24
ER
PT J
AU Moeng, MS
   Vadia, S
   Collinsworth, AW
   Lookess, S
   Capelli, P
AF Moeng, Maeyane S.
   Vadia, Suleman
   Collinsworth, Ashley W.
   Lookess, Siobhan
   Capelli, Paolo
TI Effect of Negative Pressure Wound Therapy with Instillation and Dwell
   Time on Health Care Utilization and Costs in South Africa
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE wound healing; health care utilization; health care; costs; negative
   pressure wound therapy with instillation and dwell time
AB Background. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) provides repeated wound cleansing plus the therapeutic benefits of traditional NPWT and has been elevated to a first-line therapy in some regions given evidence of its effectiveness. Objective. To examine the effect of NPWTi-d on health care utilization and costs in South Africa, where NPWTi-d may still be used as a therapy of last resort. Methods. This retrospective study was conducted utilizing a large, South African, private health insurance claims database. A matched cohort of 836 inpatients receiving NPWTi-d or NPWT for various wound types from 2018 through 2022 was created using propensity scoring. Differences in outcomes were compared between groups using t tests. Results. Despite matching, patients who received NPWTi-d were likely more complex than those who received NPWT, as indicated by a longer length of stay (18.5 days and 13.2 days, respectively; P < .001) and higher overall care costs during the index hospital admission. Readmission rates were similar between groups; however, patients who received NPWTi-d were less likely to have visits for wound-related subacute care or rehabilitation (20.1% vs 53.6%). The average cost of this care (in South African rand) was significantly lower for patients receiving NPWTi-d than for those receiving NPWT (R3 231 and R12 317, respectively; P < .001). Conclusion. Although this study had limitations, including a potential selection bias, study data suggest that NPWTi-d may reduce wound-related health care utilization and costs for some patients through decreases in visits for subacute care. More studies are needed to fully assess how NPWTi-d affects wound care pathways, patient outcomes, and costs in South Africa.
C1 [Moeng, Maeyane S.] Univ Witwatersrand, Johannesburg, South Africa.
   [Vadia, Suleman] Netcare Milpark Hosp, Johannesburg, South Africa.
   [Collinsworth, Ashley W.; Lookess, Siobhan; Capelli, Paolo] Solventum, Maplewood, MN USA.
C3 University of Witwatersrand
RP Collinsworth, AW (通讯作者)，12930 W Interstate 10, San Antonio, TX 78249 USA.
EM ACollinsworth@solventum.com
RI Moeng, Maeyane/OPN-3614-2025
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2025
VL 37
IS 10
BP 409
EP 416
DI 10.25270/wnds/25004
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA G4712
UT WOS:001624575100005
PM 41270202
DA 2026-07-24
ER
PT J
AU Ciuntu, BM
   Timofte, DV
   Ludusanu, A
   Corlade-Andrei, M
   Ciuntu, RE
   Abdulan, IM
   Zamfir, AS
   Tanevski, A
   Maxim, M
   Balan, G
   Bordianu, A
   Cobzeanu, B
AF Ciuntu, Bogdan-Mihnea
   Timofte, Daniel Vasile
   Ludusanu, Andreea
   Corlade-Andrei, Mihaela
   Ciuntu, Roxana Elena
   Abdulan, Irina Mihaela
   Zamfir, Alexandra-Simona
   Tanevski, Adelina
   Maxim, Madalina
   Balan, Gheorghe
   Bordianu, Anca
   Cobzeanu, Bogdan
TI Adaptation of Endoluminal Vacuum Therapy via Extra-Luminal Access in the
   Treatment of a High Pharyngeal Fistula: Technical Feasibility and
   Outcome
SO LIFE-BASEL
LA English
DT Article
DE piriform sinus; perforation; mediastinitis; dental prosthesis ingestion;
   EVAC; deep neck infection; foreign body; sepsis; tracheostomy
ID MANAGEMENT; CLOSURE
AB Background: Perforation of the piriform sinus is a rare but severe clinical event that can lead to cervico-thoracic mediastinitis, a life-threatening condition requiring urgent multidisciplinary intervention. Among its etiologies, accidental ingestion of foreign bodies, including dental prostheses, is uncommon but poses significant risks due to the anatomical vulnerability of the hypopharyngeal structures. Methods: We report a rare case of right piriform sinus perforation secondary to the ingestion of a dental prosthesis, complicated by cervico-mediastinitis, sepsis, tracheostomy, and sacral pressure ulcer. The clinical course required emergency surgical intervention and intensive supportive care. Results: A novel aspect of this case was the use of the Endoscopic Vacuum-Assisted Closure (EVAC) irrigation system as an adjunctive technique in the management of deep cervical drainage. Rather than approaching the fistula from within the lumen, the team created a controlled external drainage system, adaptation of the vacuum-assisted closure therapy directly over the fistulous tract. Conclusions: This case highlights the importance of early diagnosis, high clinical suspicion and coordinated management in the treatment of piriform sinus perforations. It also illustrates the potential applicability of modern technologies such as negative pressure irrigation in the complex management of deep neck infections and mediastinitis.
C1 [Ciuntu, Bogdan-Mihnea; Timofte, Daniel Vasile; Ludusanu, Andreea; Tanevski, Adelina; Maxim, Madalina] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Gen Surg, 16 Univ St, Iasi 700115, Romania.
   [Ciuntu, Bogdan-Mihnea; Timofte, Daniel Vasile; Ludusanu, Andreea; Tanevski, Adelina; Maxim, Madalina] St Spiridon Cty Emergency Clin Hosp, Gen Surg Clin, 1 Independence Blvd, Iasi 700111, Romania.
   [Corlade-Andrei, Mihaela] Grigore T Popa Univ Med & Pharm, Dept Emergency Med Surg 2, Iasi 700115, Romania.
   [Ciuntu, Roxana Elena] Grigore T Popa Univ Med & Pharm, Dept Ophtalmol, 16 Univ St, Iasi 700115, Romania.
   [Abdulan, Irina Mihaela] Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
   [Zamfir, Alexandra-Simona] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Med Sci 3, Iasi 700115, Romania.
   [Balan, Gheorghe] Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.
   [Bordianu, Anca] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Vasc Surg, 16 Univ St, Iasi 700115, Romania.
   [Cobzeanu, Bogdan] Grigore T Popa Univ Med & Pharm, ENT Clin Dept, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy; Grigore T Popa University of
   Medicine & Pharmacy; Grigore T Popa University of Medicine & Pharmacy;
   Grigore T Popa University of Medicine & Pharmacy
RP Abdulan, IM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; dantimofte@yahoo.com;
   andreealudusanu1106@yahoo.com; mihaela.corlade2@umfiasi.ro;
   roxana-elena.ciuntu@umfiasi.ro; irina.abdulan@yahoo.com;
   gheorghe-g-balan@umfiasi.ro; bordianu.anca@d.umfiasi.ro;
   bogdan788@yahoo.com
RI Timofte, Daniel/AAE-2511-2019; Ludușanu, Andreea/IAP-8113-2023;
   Cobzeanu, Mihail/MSZ-4618-2025; Tanevski, Adelina/LUZ-8095-2024;
   /AAS-5572-2020; Balan, Gheorghe/OZF-7157-2025; Corlade-Andrei,
   Mihaela/HGB-3725-2022; Abdulan, Irina/AAA-3089-2020; Ciuntu,
   Bogdan/MTF-9477-2025; Zamfir, Alexandra-Simona/HNR-0426-2023
OI Timofte, Daniel/0000-0002-6604-874X; Ludușanu,
   Andreea/0009-0003-1785-5785; 
CR Abdulsada Mustafa, 2020, VideoGIE, V5, P8, DOI [10.1016/j.vgie.2019.10.004, 10.1016/j.vgie.2019.10.004]
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NR 24
TC 0
Z9 0
U1 4
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD OCT 23
PY 2025
VL 15
IS 11
AR 1660
DI 10.3390/life15111660
PG 9
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA G5765
UT WOS:001624681500001
PM 41302085
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Erdil, A
   Celikkol, O
   Caymaz, A
   Son, A
AF Erdil, Aras
   Celikkol, Ongun
   Caymaz, Ahmet
   Son, Aybike
TI Effectiveness of topical vacuum assisted drainage in mandibular third
   molar surgeries: a randomized controlled clinical study
SO BMC ORAL HEALTH
LA English
DT Article
DE Negative pressure wound therapy; Third molar surgery; Edema; Trismus;
   Postoperative pain; Non-pharmacolgical therapy; Postoperative
   complications
ID PRESSURE WOUND THERAPY; CLOSURE; PAIN; COMPLICATIONS; VALIDITY
AB Objective This study aimed to evaluate the clinical efficacy of intraoral vacuum-assisted drainage (VAD) in reducing postoperative inflammatory complications-pain, swelling, and trismus-following the surgical extraction of impacted mandibular third molars (M3M). Materials and methods A prospective, randomized, triple-blinded, sham-controlled clinical trial was conducted with 36 systemically healthy participants undergoing surgical removal of a single M3M. Participants were randomly assigned to either the VAD group (n = 18), receiving three sessions of intraoral negative pressure therapy via a custom-made splint, or the sham-control group (n = 18), in which the apparatus was applied without suction. Primary outcomes included pain intensity, facial swelling, and maximum mouth opening (MMO), measured preoperatively and on the 2nd and 7th postoperative days. Secondary outcomes were NSAID consumption and oral health-related quality of life (OHIP-14). Statistical analysis was conducted with a significance level of 0.05. Results The VAD group showed significantly lower pain scores at all postoperative time points compared to controls (p < 0.05). Swelling was significantly reduced on postoperative day 2 (p = 0.019), and MMO was significantly greater on both postoperative days 2 and 7 (p < 0.001 and p = 0.001, respectively). Nonsteroidal anti-inflammatory drug consumption was significantly lower in the VAD group (8.1 +/- 3.2 vs. 12.8 +/- 4.6 tablets, p = 0.001), and OHIP-14 scores indicated improved quality of life on postoperative day 7 (p = 0.021). Conclusions Within the limitations of this preliminary trial, vacuum-assisted drainage showed potential in reducing early postoperative complications following M3M surgery. These findings support further investigation into its clinical application. Clinical relevance This study introduces an innovative intraoral vacuum-assisted drainage technique that enhances patient recovery after mandibular third molar surgery. By reducing inflammatory complications and analgesic dependency, it offers a promising adjunct to standard postoperative care, particularly in patients where NSAID use is limited or adverse effects are a concern. Trial registration ClinicalTrials.gov Identifier NCT06758258. Date of Registration 26/11/2024 (retrospectively registered).
C1 [Erdil, Aras; Caymaz, Ahmet] Usak Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Usak, Turkiye.
   [Celikkol, Ongun] Adnan Menderes Univ, Fac Dent, Dept Prosthodont, Aydin, Turkiye.
   [Son, Aybike] Usak Univ, Fac Dent, Dept Prosthodont, Usak, Turkiye.
C3 Usak University; Adnan Menderes University; Usak University
RP Erdil, A (通讯作者)，Usak Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Usak, Turkiye.
EM aras.erdil@usak.edu.tr; ongun.celikkol@usak.edu.tr;
   ahmet.caymaz@usak.edu.tr; aybike.son@usak.edu.tr
RI Erdil, Aras/LKO-1120-2024
OI Erdil, Aras/0000-0002-9582-5114; caymaz, ahmet/0009-0005-5699-8425;
   Çelikkol, Ongun/0000-0002-9401-4133
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NR 56
TC 0
Z9 0
U1 2
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6831
J9 BMC ORAL HEALTH
JI BMC Oral Health
PD NOV 25
PY 2025
VL 25
IS 1
AR 1838
DI 10.1186/s12903-025-07243-0
PG 17
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA H2139
UT WOS:001625320800001
PM 41291693
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhang, GB
   Gao, SH
   Yin, QF
   Qie, P
   Song, YB
   Wang, HE
AF Zhang, Guibin
   Gao, Shuhui
   Yin, Qifan
   Qie, Peng
   Song, Yongbin
   Wang, Huien
TI A retrospective comparative study on the short-term and long-term
   efficacy of different treatments for anastomotic leakage after
   esophagectomy
SO MEDICINE
LA English
DT Article
DE anastomotic fistula; conservative management; endoscopic intervention;
   esophagectomy; quality of life; short-term and long-term efficacy
ID CLASSIFICATION
AB This study aims to evaluate the short-term and long-term efficacy of various treatment modalities for anastomotic leakage following esophagectomy. We conducted a retrospective analysis of patients diagnosed with anastomotic leakage after esophageal surgery from January 2020 to December 2023 at our institution. A total of 385 patients underwent esophagectomy, with 30 patients with anastomotic leakage enrolled. Patients were stratified into 2 groups based on the treatment approach: a control group receiving conservative management (n = 15), and an observation group (n = 15), which underwent endoscopic or surgical interventions. We collected comprehensive patient data, compared clinical outcomes including our institutional clinical efficacy score, evaluated fistula closure rates, and documented the incidence of postoperative complications. The Dysphagia Handicap Index questionnaire was utilized to assess the impact of dysphagia on patients' quality of life. No significant differences were observed in the baseline surgical and demographic characteristics of the 2 groups (P > .05). At 3 and 6 months post-treatment, the clinical treatment effect scores for the observation group (5.67 +/- 0.72 and 8.33 +/- 1.63) were significantly higher than those of the control group (4.73 +/- 0.88 and 6.27 +/- 1.03) (P < .001). Additionally, the effective fistula closure rate was markedly greater in the observation group (73.33%) compared to the control group (53.33%) (P < .05). There was no significant difference in the incidence of complications between the 2 groups (P > .05). Furthermore, the Dysphagia Handicap Index scores, functional, emotional, and physical, were significantly lower in the observation group than in the control group (P < .001). Subgroup analysis showed effective closure rates of 75.0% for stenting, 80.0% for endoscopic vacuum-assisted closure, and 50.0% for reoperation. Endoscopic or surgical interventions demonstrate a significant improvement in fistula closure rates and treatment efficacy in the short term compared to traditional conservative management. Long-term follow-up indicates that these interventions enhance swallowing function and markedly improve quality of life, alleviating emotional and physiological burdens. Importantly, although these approaches are invasive, the complication rates did not increase, underscoring their safety in this cohort.
C1 [Zhang, Guibin; Yin, Qifan; Qie, Peng; Song, Yongbin; Wang, Huien] Hebei Gen Hosp, Dept Thorac Surg, 348 West He Ping Rd, Shijiazhuang 050000, Hebei, Peoples R China.
   [Gao, Shuhui] Hebei Gen Hosp, Dept Resp Med, Shijiazhuang, Hebei, Peoples R China.
RP Song, YB (通讯作者)，Hebei Gen Hosp, Dept Thorac Surg, 348 West He Ping Rd, Shijiazhuang 050000, Hebei, Peoples R China.
EM exca48@163.com; ukgoui@163.com; kzpn80@163.com; nnut80@163.com;
   hebxwk@163.com; lxpz89@163.com
RI Gao, shuhui/KYR-2542-2024
FU Research Fund Project of Hebei Provincial Health Department [20180124]
FX This study was funded by Medical Science Research Project of Hebei
   (20180124).
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NR 28
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV 21
PY 2025
VL 104
IS 47
AR e45764
DI 10.1097/MD.0000000000045764
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA H3645
UT WOS:001625471400011
PM 41305803
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Suszczynska, J
   Grabala, M
   Grabala, P
AF Suszczynska, Joanna
   Grabala, Michal
   Grabala, Pawel
TI Modulation of Surgical Site Infection Risk in Spinal and Thoracic
   Surgeries Through Operative Parameters: A Narrative Review
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE surgical site infection; spinal surgery; thoracic surgery;
   negative-pressure wound therapy; antibiotic prophylaxis; risk factors
ID PRESSURE WOUND THERAPY; INTRAOPERATIVE VANCOMYCIN; POSTERIOR APPROACH;
   FUSION; COMPLICATIONS; METAANALYSIS; PREVENTION; RESECTION;
   INSTRUMENTATION; READMISSION
AB Background: Surgical site infections (SSIs) following spinal and thoracic procedures are associated with prolonged hospitalization and increased morbidity, with incidence rates of 2-15% in spinal surgery and 3-12% in thoracic procedures. Multiple patient-related and procedure-specific factors contribute to wound complications, including diabetes mellitus, obesity, smoking, extended surgical time, excessive tissue dissection, and hardware implantation. Implementing evidence-based prevention and early intervention strategies is essential in high-risk surgical cohorts. Methods: This narrative review followed searches in PubMed, Scopus, ScienceDirect, Cochrane Library, and Embase for studies published between January 2000 and October 2025. Eligible peer-reviewed articles examined SSI incidence, risk factors, or prevention strategies in adult patients undergoing thoracic or spinal surgery. Data extraction focused on operative parameters, antibiotic prophylaxis regimens, negative-pressure wound therapy (NPWT) use, and patient outcomes. Results: Evidence from found recent studies was synthesized. Key findings demonstrated that operative duration > 4 h increased SSI odds by 41% per additional hour, and blood loss > 500 mL doubled infection risk. Prophylactic NPWT reduced deep SSI rates by 50% in high-risk patients (BMI >= 35, diabetes, multilevel instrumentation). Intrawound vancomycin powder reduced deep SSIs by 50-60%, particularly in multilevel fusions. Administering prophylactic antibiotics within 30 min of incision was significantly more effective than at 60 min, with a 23% relative risk reduction. Weight-adjusted antibiotic dosing in obese patients lowered SSI rates from 5.1% to 2.9%. Conclusions: Operative parameters strongly predict SSI risk. An integrated risk- and evidence-based approach to wound management following spinal and thoracic surgeries-combining optimized antibiotic prophylaxis, risk-stratified NPWT application, and operative technique modifications-can significantly reduce SSI incidence. Successful implementation requires institutional commitment, multidisciplinary collaboration, and continuous quality improvement to optimize patient outcomes.
C1 [Suszczynska, Joanna; Grabala, Michal] Med Univ Bialystok, Clin Dept Gen & Gastroenter Surg 2, Ul M Sklodowskiej Curie 24a, PL-15276 Bialystok, Poland.
   [Grabala, Pawel] Polish Mothers Mem Hosp Res Inst, Dept Neurosurg, Rzgowska 281-289, PL-93338 Lodz, Poland.
C3 Medical University of Bialystok; Polish Mother's Memorial Hospital -
   Research Institute
RP Grabala, P (通讯作者)，Polish Mothers Mem Hosp Res Inst, Dept Neurosurg, Rzgowska 281-289, PL-93338 Lodz, Poland.
EM joanna.suszczynska@uskwb.pl; michal@grabala.pl; pgrabala@wp.pl
RI Grabala, Pawel/AAV-5125-2020
OI Grabala, Pawel/0000-0001-7059-2935
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NR 163
TC 5
Z9 5
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV 17
PY 2025
VL 14
IS 22
AR 8124
DI 10.3390/jcm14228124
PG 44
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA H5943
UT WOS:001625702200001
PM 41303160
OA gold
DA 2026-07-24
ER
PT J
AU Gong, J
   Sun, XH
   Fu, H
   Zhang, Y
   Gao, T
AF Gong, Juan
   Sun, Xiaohong
   Fu, Hong
   Zhang, Yu
   Gao, Ting
TI Comparative efficacy and safety of non-pharmacological nursing
   interventions for diabetic foot ulcers: a systematic review and network
   meta-analysis
SO BMC NURSING
LA English
DT Article
DE Diabetic foot ulcer; Non-pharmacological interventions; Nursing care;
   Network meta-analysis; Wound healing
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; SHOCK-WAVE THERAPY;
   VACUUM-ASSISTED CLOSURE; LEVEL LASER THERAPY; CONTROLLED-TRIAL;
   DOUBLE-BLIND; CONTINUOUS DIFFUSION; 2 MULTICENTER; STIMULATION
AB BackgroundNon-pharmacological nursing interventions are increasingly employed to enhance diabetic foot ulcer (DFU) healing and patient outcomes. However, the comparative effectiveness and safety profiles of various adjunctive nursing strategies remain unclear. This network meta-analysis systematically evaluated and ranked non-pharmacological nursing interventions for DFU management.MethodsA comprehensive systematic search was conducted in PubMed, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, and Web of Science from inception to March 31, 2025. Randomized controlled trials (RCTs) comparing non-pharmacological adjunctive nursing interventions (e.g., hyperbaric oxygen therapy [HBOT], light therapy [LT], ultrasound therapy [US], extracorporeal shock-wave therapy [ESWT], exercise therapy [EXER], continuous diffusion of oxygen [CDO], negative pressure wound therapy [NPWT]) with standard care or alternative interventions for DFU were included. Primary outcomes assessed were healing rate, healing time, wound area reduction, recurrence rate, amputation rate, and adverse events. Bayesian network meta-analysis was conducted using random-effects models, with results expressed as odds ratios (OR), standardized mean differences (SMD), and surface under cumulative ranking curves (SUCRA).ResultsSixty-seven RCTs involving 5957 patients were included. LT significantly increased healing rates compared with standard care (OR = 7.62; 95% CI, 2.92-19.90; SUCRA = 88.8%). US produced the largest wound area reduction (SMD = -3.17; 95% CI, -4.81 to -1.53; SUCRA = 98.4%). ESWT was superior in shortening healing time (SMD = -2.02; 95% CI, -3.33 to -0.71; SUCRA = 94.4%) and reducing amputation risk (OR = 0.40; 95% CI, 0.23-0.70). EXER significantly reduced recurrence rates (OR = 0.07; 95% CI, 0.02-0.33; SUCRA = 97.4%). CDO demonstrated the fewest adverse events (OR = 0.27; 95% CI, 0.08-0.85; SUCRA = 89.2%).ConclusionThis analysis provides targeted evidence for selecting adjunctive nursing interventions based on specific clinical goals. LT and US are optimal for enhancing wound closure and reducing wound area, ESWT is most effective for rapid healing and limb preservation, EXER excels at recurrence prevention, and CDO offers superior safety. These findings facilitate tailored nurse-led care plans and inform clinical guidelines.
C1 [Gong, Juan; Sun, Xiaohong; Zhang, Yu] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, Hefei 230022, Anhui, Peoples R China.
   [Fu, Hong; Gao, Ting] Anhui Med Univ, Affiliated Hosp 1, Dept Crit Care Med, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Gao, T (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Crit Care Med, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China.
EM 51583025@qq.com
RI Sun, Xiaohong/LGY-9610-2024
FU Research Funding for Doctoral Talents of the First Affiliated Hospital
   of Anhui Medical University [1952]
FX The research of our article was funded by Research Funding for Doctoral
   Talents of the First Affiliated Hospital of Anhui Medical University
   (Grant No.1952).
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NR 99
TC 0
Z9 0
U1 5
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6955
J9 BMC NURS
JI BMC Nurs.
PD NOV 26
PY 2025
VL 24
IS 1
AR 1445
DI 10.1186/s12912-025-04065-x
PG 14
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA I4132
UT WOS:001626522700003
PM 41299407
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ben-Nakhi, M
   Albeshri, H
   Aljindan, F
   Alkhatieb, M
   Al-Malaq, A
   Al Subhi, F
   Baguneid, M
   Cherubino, M
   Mushara, SF
   Khattab, Y
   Laher, S
   Ribeiro, MAF Jr
   Vadia, S
   Trivedi, S
   Portou, MJ
AF Ben-nakhi, Muneera
   Albeshri, Heitham
   Aljindan, Fahad
   Alkhatieb, Maram
   Al-Malaq, Ali
   Al Subhi, Fatema
   Baguneid, Mohamed
   Cherubino, Mario
   Mushara, Samiah Faraj
   Khattab, Yasser
   Laher, Saadia
   Ribeiro Jr, Marcelo A. F.
   Vadia, Suleman
   Trivedi, Sadhana
   Portou, Mark J.
TI Negative Pressure Wound Therapy Use: Recommendations and Insights From a
   Middle Eastern Panel of Experts
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE algorithm; negative pressure wound therapy; patient care management;
   surgical wounds; wounds
ID DIABETIC FOOT ULCERS; BED PREPARATION; INSTILLATION; DRESSINGS; CARE
AB The number of patients requiring wound care is increasing, placing a burden on healthcare institutions and clinicians. While negative pressure wound therapy (NPWT) use has become increasingly common, Middle East-specific wound care guidelines are limited. An in-person meeting was held in Dubai with 15 wound care experts to develop guidelines for NPWT and NPWT with instillation and dwell (NPWTi-d) use for the Middle East. A literature search was performed using PubMed, Science Direct and Cochrane Reviews. Prior to the meeting, panel members reviewed literature and existing guidelines on NPWT and/or NPWTi-d use. A wound management treatment algorithm was created. Patient and wound assessment at presentation and throughout the treatment plan was recommended. Primary closure was recommended for simple wounds, and NPWT use was suggested for complex wounds requiring wound bed preparation. NPWTi-d use was advised when wound cleansing is required, if the patient is unsuitable for surgical debridement, or if surgical debridement is delayed. When NPWTi-d is unavailable, panel members recommended NPWT. Panel members recommended NPWT for wound bed preparation and NPWTi-d when wound cleansing is needed. These recommendations provide general guidance for NPWT and NPWTi-d use and should be updated as more clinical evidence becomes available.
C1 [Ben-nakhi, Muneera] Al Adan Hosp, Plast & Reconstruct Surg Unit, Ahmadi, Kuwait.
   [Albeshri, Heitham] King Faisal Specialist Hosp & Res Ctr, Vasc & Endovascular Surg, Jeddah, Saudi Arabia.
   [Aljindan, Fahad] King Fahad Med City Makkah, Plast & Reconstruct Surg, Mecca, Saudi Arabia.
   [Alkhatieb, Maram] King Abdulaziz Univ, Gen Surg Dept, Jeddah, Saudi Arabia.
   [Al-Malaq, Ali] King Faisal Specialist Hosp & Res Ctr, Plast Surg, Riyadh, Saudi Arabia.
   [Al Subhi, Fatema] Prince Sultan Mil Med City, Plast Surg & Burn Unit, Riyadh, Saudi Arabia.
   [Baguneid, Mohamed] Sheikh Shakhbout Med City, Vasc Surg, Abu Dhabi, U Arab Emirates.
   [Cherubino, Mario] Cleveland Clin, Plast Surg, Abu Dhabi, U Arab Emirates.
   [Mushara, Samiah Faraj] King Fahad Gen Hosp, Minist Hlth, Jeddah, Saudi Arabia.
   [Khattab, Yasser] Kings Coll Hosp London, Mediclin City Hosp, Plast Aesthet & Hand Surg, Dubai Healthcare City, Dubai, U Arab Emirates.
   [Laher, Saadia] Netcare Alberton Union Hosp, Plast & Reconstruct Surg, Johannesburg, South Africa.
   [Laher, Saadia] Midvaal Hosp, Johannesburg, South Africa.
   [Ribeiro Jr, Marcelo A. F.] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Surg Trauma & Acute Care Surg, Baltimore, MD USA.
   [Vadia, Suleman] Netcare Milpk & Rosebank Hosp, Plast Reconstruct & Cosmet Surg, Johannesburg, South Africa.
   [Trivedi, Sadhana] Solventum, Med Surg, Dublin, Ireland.
   [Portou, Mark J.] Royal Free Hosp, Vasc Surg, London, England.
C3 Al Adan Hospital; King Faisal Specialist Hospital & Research Center;
   King Abdulaziz University; King Faisal Specialist Hospital & Research
   Center; Prince Sultan Military Medical City; Sheikh Khalifa Specialty
   Hospital; Cleveland Clinic Foundation; Ministry of Health - Saudi
   Arabia; King Fahd Hospital Jeddah; University System of Maryland;
   University of Maryland Baltimore; University of London; University
   College London; Royal Free London NHS Foundation Trust; UCL Medical
   School
RP Portou, MJ (通讯作者)，Royal Free Hosp, Vasc Surg, London, England.
EM m.portou@nhs.net
RI Alkhatieb, Maram/ABE-3378-2020; Cherubino, Mario/N-1780-2019
OI Alkhatieb, Maram/0000-0002-7060-6660; Cherubino,
   Mario/0000-0003-1196-3075
FU Solventum Corporation
FX The authors thank Julie M. Robertson, Julissa Ramos and Ricardo Martinez
   (Solventum) for assistance with manuscript preparation and editing.
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NR 44
TC 1
Z9 1
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD NOV 27
PY 2025
VL 22
IS 12
AR e70791
DI 10.1111/iwj.70791
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA I7333
UT WOS:001626842800001
PM 41306082
OA gold
DA 2026-07-24
ER
PT J
AU Izawa, Y
   Nishida, M
   Futamura, K
   Murakami, H
   Sato, K
   Tsuchida, Y
AF Izawa, Yuta
   Nishida, Masahiro
   Futamura, Kentaro
   Murakami, Hiroko
   Sato, Kazuo
   Tsuchida, Yoshihiko
TI Staged wound closure using tension-reducing taping technique with
   negative pressure wound therapy in lower extremity open fractures: A
   retrospective review
SO JOURNAL OF ORTHOPAEDIC SCIENCE
LA English
DT Review
DE Open fracture; Primary wound closure; Staged wound closure; Wound edge
   necrosis
ID SHOELACE TECHNIQUE; FASCIOTOMY; RECONSTRUCTION; MANAGEMENT; INFECTION;
   TRAUMA; FLAP
AB Background: In the treatment of lower extremity open fractures Gustilo-Anderson classification types IIIA/IIIB borderline cases, closing open wound under strong tension may lead to wound edge necrosis and the need for soft tissue reconstruction. The purpose of this study is to examine whether staged wound closure using tension-reducing taping with negative pressure wound therapy (NPWT) could prevent wound edge necrosis in borderline type lower extremity open fractures. Materials and methods: Patients with IIIA/IIIB borderline type lower extremity open fractures who were treated at our institution were included. The patients were divided into two groups: those who underwent conventional wound closure (Group 1) and those who underwent staged closure using tensionreducing taping (Group 2). Characteristics of patients and their injuries were compared between the two groups. In addition, the presence or absence of wound edge necrosis after wound closure, soft tissue reconstruction, and wound infection were compared between the two groups. Results: Twenty-six patients were included in Group 1 and 21 patients were included in Group 2. There were no significant differences in characteristics of patients and their injuries between the two groups. The rate of wound edge necrosis and the need for local flaps were significantly higher in Group 1 (p = 0.002, 0.027). There was no significant difference in infection rates between the two groups (p = 0.495). Conclusion: For IIIA/IIIB borderline type lower extremity open fractures, staged wound closure using tension-reducing taping technique with NPWT can reduce wound edge necrosis and prevent the transition to iatrogenic type IIIB. (c) 2025 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Izawa, Yuta; Nishida, Masahiro; Futamura, Kentaro; Tsuchida, Yoshihiko] Shonan Kamakura Gen Hosp, Dept Trauma Ctr, 1370-1 Okamoto, Kamakura, Kanagawa, Japan.
   [Izawa, Yuta; Murakami, Hiroko; Sato, Kazuo; Tsuchida, Yoshihiko] Sapporo Higashi Tokushukai Hosp, Dept Orthoped, Trauma Ctr, Kita 33 Jou Higashi 14 Chome 3-1, Sapporo, Hokkaido, Japan.
RP Izawa, Y (通讯作者)，Shonan Kamakura Gen Hosp, Dept Trauma Ctr, 1370-1 Okamoto, Kamakura, Kanagawa, Japan.
EM yutaizawa18@gmail.com; drmint2001@yahoo.co.jp; kenshin@friend.ocn.ne.jp;
   hmura@pb3.so-net.ne.jp; tetukazu812@gmail.com; ytutida@world.ocn.ne.jp
CR Asgari MM, 2000, ANN PLAS SURG, V44, P225, DOI 10.1097/00000637-200044020-00017
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   Lee JY, 2014, WORLD J EMERG SURG, V9, DOI 10.1186/1749-7922-9-29
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Putnis Sven, 2014, Open Orthop J, V8, P142, DOI 10.2174/1874325001408010142
   Rajasekaran S, 2007, INJURY, V38, P890, DOI 10.1016/j.injury.2007.01.013
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   Scharfenberger AV, 2017, J ORTHOP TRAUMA, V31, P121, DOI 10.1097/BOT.0000000000000751
   Sinha K, 2013, ADV ORTHOP, V2013, DOI 10.1155/2013/245940
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0949-2658
EI 1436-2023
J9 J ORTHOP SCI
JI J. Orthop. Sci.
PD NOV
PY 2025
VL 30
IS 6
BP 1121
EP 1125
DI 10.1016/j.jos.2025.03.002
EA NOV 2025
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA J0970
UT WOS:001627207100015
PM 40122733
DA 2026-07-24
ER
PT J
AU Hahn, HM
   Lee, DH
   Lee, IJ
AF Hahn, Hyung Min
   Lee, Dong Hwan
   Lee, Il Jae
TI Ready-to-Use Micronized Human Acellular Dermal Matrix to Accelerate
   Wound Healing in Diabetic Foot Ulcers: A Prospective Randomized Pilot
   Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE acellular dermal matrix; advanced therapy; cellular and/or tissue-based
   product; diabetic foot ulcer; micronized human acellular dermal matrix;
   negative-pressure wound therapy; wound healing
ID LOWER-EXTREMITIES; THERAPY
AB OBJECTIVE: To examine and report clinical outcomes of a ready-to-use micronized dermal matrix for diabetic foot ulcers (DFUs) and compare it to treatment with conventional negative-pressure wound therapy (NPWT) only.
   METHODS: The researchers randomly allocated 30 DFUsWagner grade 2 or higher from 30 adult patients into two groups. The control group (n = 15) was treated with conventional NPWT, and the experimental group (n = 15) was treated with micronized dermal matrix and NPWT. The researchers evaluated the following outcomes: granulation tissue formation, proportion of patients with closed or granulated wounds at 42 and 120 days, achievement of complete wound healing in the 6 months of follow-up, and intervals from enrollment to final surgical procedures.
   RESULTS: All 15 wounds treated with the micronized matrix showed healthy granulation tissue without noticeable complications during follow-up. At 42 days, 46.7% of wounds in the experimental group had closed compared with 28.6% in the conventional NPWT group (P =.007). At 120 days, 86.7% of the experimental group had completely closed wounds, compared with 57.1% in the conventional therapy group (P =.040). During the 6-month follow-up period, 93.3% of the experimental group achieved complete wound healing compared with 85.7% of the conventional therapy group (P =.468).
   CONCLUSIONS: The healing outcomes for DFUs in the experimental group were superior when micronized matrix treatment was combined with NPWT.
C1 [Hahn, Hyung Min] Ajou Univ, Sch Med, Suwon, South Korea.
   [Lee, Dong Hwan; Lee, Il Jae] Ajou Univ, Dept Plast & Reconstruct Surgery, Suwon, South Korea.
C3 Ajou University; Ajou University
RP Hahn, HM (通讯作者)，Ajou Univ, Sch Med, Suwon, South Korea.
FU Korea Health Industry Development Institute grant
FX The authors thank Editage (www.editage.co.kr) for English language
   editing. This research was supported by a Korea Health Industry
   Development Institute grant to Ajou UniversityMedical Center. The
   authors have disclosed no other financial relationships related to this
   article. Submitted May 28, 2020; accepted in revised form September 3,
   2020.
CR Banta MN, 2003, DERMATOL SURG, V29, P863, DOI 10.1046/j.1524-4725.2003.29234.x
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Bonnans C, 2014, NAT REV MOL CELL BIO, V15, P786, DOI 10.1038/nrm3904
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   Dussoyer M, 2020, APPL SCI-BASEL, V10, DOI 10.3390/app10103435
   Iorio ML, 2012, PLAST RECONSTR SURG, V130, p232S, DOI 10.1097/PRS.0b013e3182615703
   Kim YH, 2019, J WOUND CARE, V28, pS12, DOI 10.12968/jowc.2019.28.Sup4.S12
   Kirsner RS, 2015, INT WOUND J, V12, P646, DOI 10.1111/iwj.12185
   Levy D, 2004, WOUNDS, V16, P359
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   Yonehiro L, 2013, WOUNDS, V25, P340
NR 15
TC 17
Z9 18
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAY
PY 2021
VL 34
IS 5
BP 1
EP 6
DI 10.1097/01.ASW.0000741512.57300.6d
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA J6167
UT WOS:001627729200001
PM 33852465
DA 2026-07-24
ER
PT J
AU Theodorakopoulos, G
   Armstrong, DG
AF Theodorakopoulos, George
   Armstrong, David G.
TI Biofilm in Diabetic Foot Ulcers: A Systematic Narrative Review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
AB Biofilms are a key driver of chronicity and treatment failure in diabetic foot ulcers (DFUs), yet clinical evidence quantifying their impact and management remains fragmented. This systematic narrative review synthesised recent evidence (2015-2025) on the prevalence, diagnostics, and management of biofilm in DFUs. A Systematic Review of the Literature (SRL) was conducted following PRISMA 2020 guidelines across PubMed/MEDLINE, Scopus, Cochrane Library and ScienceDirect. Eligible studies included adults with DFUs reporting biofilm/bioburden metrics or interventions aimed at biofilm disruption. Risk of bias was assessed using RoB 2 for randomised trials and ROBINS-I for non-randomised studies. Data were narratively synthesised by evidence tier (Tier 1 = clinical; Tier 2 = preclinical/mechanistic). Of 600 records screened, 25 studies met inclusion criteria (Tier 1 n = 9; Tier 2 n = 5; reviews n = 11). Over half of bacterial isolates in DFUs were biofilm producers, with multidrug resistance exceeding 90% in several cohorts. Fungi were detected in 31% of ulcers by qPCR but only 9% by culture. Tier 1 clinical evidence supports standard care components-debridement, antiseptics, and negative-pressure wound therapy-for improved healing, though direct antibiofilm outcomes remain limited. Emerging strategies (enzymatic agents, peptides, cold plasma, smart dressings) show promise in vitro but lack clinical translation. Evidence for direct antibiofilm efficacy in DFUs remains scarce. Current data justify maintaining guideline-based care while prioritising trials that integrate validated biofilm endpoints, standardised microbiological methods, and antifungal components. Distinguishing established from experimental approaches is essential to advancing safe, evidence-based biofilm management in DFUs.
C1 [Theodorakopoulos, George] Technol Educ Inst Patras, Patras, Greece.
   [Theodorakopoulos, George] Queen Margaret Univ, Edinburgh, Scotland.
   [Theodorakopoulos, George] Univ West Attica, Aigaleo, Greece.
   [Theodorakopoulos, George] Univ Thessaly, Larisa, Greece.
   [Theodorakopoulos, George] Natl & Kapodistrian Univ Athens, Athens, Greece.
   [Armstrong, David G.] Southwestern Acad Limb Salvage Alliance SALSA, Los Angeles, CA 90033 USA.
   [Armstrong, David G.] Ctr Stream Healthcare Pl C2SHiP, Alexandria, VA USA.
   [Armstrong, David G.] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA.
C3 Western Greece University of Applied Sciences (TEI of Western Greece);
   Queen Margaret University; University of West Attica; University of
   Thessaly; National & Kapodistrian University of Athens; University of
   Southern California
RP Theodorakopoulos, G (通讯作者)，Technol Educ Inst Patras, Patras, Greece.; Theodorakopoulos, G (通讯作者)，Queen Margaret Univ, Edinburgh, Scotland.; Theodorakopoulos, G (通讯作者)，Univ West Attica, Aigaleo, Greece.; Theodorakopoulos, G (通讯作者)，Univ Thessaly, Larisa, Greece.; Theodorakopoulos, G (通讯作者)，Natl & Kapodistrian Univ Athens, Athens, Greece.
EM george_theodorakopoulos@yahoo.gr
RI ; Theodorakopoulos, George/OZD-6104-2025
OI Theodorakopoulos, George/0009-0008-1196-539X; 
FU USC Southwestern Academic Limb Salvage Alliance (SALSA); USC Center to
   Stream Healthcare; Musculoskeletal Medicine at the National and
   Kapodistrian University of Athens
FX The authors thank the USC Southwestern Academic Limb Salvage Alliance
   (SALSA) and the USC Center to Stream Healthcare in Place (C2SHiP) for
   academic inspiration and guidance. G.T. also acknowledges his ongoing
   postgraduate training as an MSc Candidate in Rheumatology and
   Musculoskeletal Medicine at the National and Kapodistrian University of
   Athens, which has enriched his interdisciplinary understanding of
   diabetic foot management.
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NR 27
TC 6
Z9 6
U1 5
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC 3
PY 2025
VL 22
IS 12
AR e70795
DI 10.1111/iwj.70795
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA M2723
UT WOS:001630404800001
PM 41339278
OA gold
DA 2026-07-24
ER
PT J
AU Huang, LS
   Wang, LF
   Yang, JH
   Zhang, HB
AF Huang Lisong
   Wang Lianfu
   Yang Jinhong
   Zhang Haibin
TI Clinical effect analysis of using medical glue versus conventional
   suturing to treat dog bite in children's maxillofacial region after
   negative pressure sealing drainage
SO MEDICINE
LA English
DT Article
DE children; dog bite; maxillofacial region; medical glue; negative
   pressure sealing drainage
ID WOUND THERAPY; INJURIES
AB Background: To compare the clinical effectiveness of applying medical glue versus conventional suturing after primary suturing and continuous vacuum sealing drainage (VSD) technology in the treatment of facial wounds caused by dog bites in children's maxillofacial region, with respect to operation time, wound infection rate, treatment effect, and patient satisfaction. Methods: From May 2020 to July 2022, 68 children with a dog bite in the maxillofacial region were randomly divided into medical glue and conventional suturing groups. The patients in both groups were treated with conventional debridement, tetanus and/or rabies immunization, and antibiotic therapy. The medical glue group was treated with VSD after the first-stage of the loose suture of the wound. After 5 days, the suture was removed, and the wound was tightly bonded with medical glue again. The conventional suturing group was treated with VSD after the first-stage of loose suture of the wound. The primary outcomes were the operation time and satisfaction of the 2 groups, and the secondary outcomes was the wound infection rate. Results: The operation time of the medical glue group was significantly lower than that of the conventional suturing group. However, there was no significant difference between the 2 groups in the wound infection rate. Still, the patient satisfaction was significantly better in the medical glue group than the conventional suturing group with statistically significant difference (P <.05). Conclusion: In conclusion, applying medical glue after using negative pressure sealing drainage in treating maxillofacial dog bites can reduce surgeons work intensity, lessen children's pain, and improve the clinical treatment effect.
C1 [Huang Lisong; Wang Lianfu; Yang Jinhong; Zhang Haibin] Aerosp Ctr Hosp, Beijing 100049, Peoples R China.
C3 Aerospace Center Hospital
RP Zhang, HB (通讯作者)，Aerosp Ctr Hosp, Beijing 100049, Peoples R China.
EM dr_zhb@163.com
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NR 36
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP 15
PY 2023
VL 102
IS 37
DI 10.1097/MD.0000000000034837
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M4049
UT WOS:001630537400001
PM 37713853
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sekác, J
   Koller, T
   Bujnáková, J
   Durdík, S
AF Sekac, Jaroslav
   Koller, Tomas
   Bujnakova, Julia
   Durdik, Stefan
TI Modern Concepts of the Diagnosis and Treatment of Necrotizing
   Fasciitis-Review of 30 Cases
SO BRATISLAVA MEDICAL JOURNAL
LA English
DT Article
DE Necrotizing fasciitis; Early surgery; Negative pressure wound therapy;
   Prognostic score; Point-of-care ultrasound; Single-center study
ID EMERGENCY-DEPARTMENT; TISSUE; MORTALITY; MICROBIOLOGY; PREDICTORS; LIMB
AB BackgroundNecrotizing fasciitis (NF) is a rare, severe and often lethal soft-tissue infection.ObjectiveThe objective of this retrospective study was to analyze the incidence, clinical outcomes of NF in our region compared to the global data and to review modern surgical techniques, in particular, negative pressure wound therapy (NPWT). The secondary aim was to assess whether LRINEC scoring had prognostic value.MethodsThe study reviews 30 cases of histologically confirmed NF in the period of 2014 to 2023. We have evaluated demographic data, comorbidities, microbiological findings, surgical timing, and treatment outcomes.ResultsThe incidence of NF in our medical center was elevated in comparison to other literature reports, likely due to improved diagnostics. The mortality rate was 3.3%, which was lower compared to the global average (20-40%), which may be related to early diagnosis and prompt surgical intervention in our center. Given the small sample, this finding must be interpreted descriptively. NPWT was used in approximately half of cases as a selective adjunct to wound care and was associated with favorable wound healing and functional outcomes. In more than half of the cases, the LRINEC score exceeded 8, but no significant correlation with mortality was observed.ConclusionTo our knowledge, this study proposes one of the more comprehensive studies analyzing NF in Central Europe. Early surgical exploration combined with NPWT was associated with excellent outcomes in our cohort and may provide a useful framework for further evaluation of NF management strategies.
C1 [Sekac, Jaroslav; Bujnakova, Julia] Comenius Univ, Fac Med, Clin Surg, Bratislava 81372, Slovakia.
   [Koller, Tomas] Comenius Univ, Fac Med, Clin Internal Med, Bratislava 81372, Slovakia.
   [Durdik, Stefan] Comenius Univ, Fac Med, Clin Oncol & Surg, Bratislava 81250, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava; Comenius
   University Bratislava
RP Sekác, J (通讯作者)，Comenius Univ, Fac Med, Clin Surg, Bratislava 81372, Slovakia.
EM jaroslavsekac@yahoo.com
CR Abdalla TSA, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0285048
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NR 42
TC 0
Z9 0
U1 3
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PD JAN
PY 2026
VL 127
IS 1
BP 311
EP 322
DI 10.1007/s44411-025-00456-3
EA DEC 2025
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DA9DU
UT WOS:001632319200001
OA gold
DA 2026-07-24
ER
PT J
AU Pronk, AJM
   Van Oostendorp, JY
   Han-Geurts, IJM
   Madelska, S
   Buskens, CJ
   Bemelman, WA
   Madelski, M
   Breeczewski, S
   Przybylska, K
   Michalowska, M
   Banasiewicz, T
   ten Bokkel-Huinink, T
   Barnier, R
   Van Langen, R
AF Pronk, A. J. M.
   Van Oostendorp, J. Y.
   Han-Geurts, I. J. M.
   Madelska, S.
   Buskens, C. J.
   Bemelman, W. A.
   Madelski, M.
   Breeczewski, S.
   Przybylska, K.
   Michalowska, M.
   Banasiewicz, T.
   Ten Bokkel-Huinink, T.
   Barnier, R.
   Van Langen, R.
TI Semiflex-assisted vacuum therapy for perianal fistulas: the Semiflex
   pilot study
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE Perianal fistulas; Vaccuumtherapy; Surgery
ID CROHNS-DISEASE
AB IntroductionPerianal fistulas often require multiple surgical interventions because of their chronic nature. Various sphincter-sparing techniques achieve clinical closure rates of up to 70%, yet recurrence remains a major challenge. Vacuum-assisted closure (VAC) therapy has shown promise in wound healing, but its application in perianal fistulas remains largely unexplored. The Semiflex catheter was developed to facilitate outpatient vacuum therapy without the need for general anesthesia during catheter exchanges. This pilot study aimed to evaluate the feasibility and clinical applicability of the Semiflex catheter in perianal fistula management.MethodsThe Semiflex pilot study was a two-part feasibility trial. The first part assessed proof of principle in ten patients, while the second part, a multicentre study, aimed to confirm feasibility in 20 patients. Feasibility included smoothness of insertion and changing of the Semiflex catheters, capability of proper fixation of the Semiflex catheter, maintaining vacuum for more than 48 h, and compliance to the therapy in terms of pain and discomfort. The protocol was scored feasible if at least 50% of the exchanges met all these criteria in at least 70% of patients. Secondary outcomes included clinical fistula closure, radiological healing, and treatment-related adverse events.ResultsTwenty patients were included (median age 39.5 years; 70% Crohn's disease). Thirteen Semiflex treatments were scored as feasible, below the predefined threshold. Clinical fistula closure was observed in 50% of patients, but none showed radiological healing at 3 months. One serious adverse event occurred, requiring early treatment discontinuation, while minor complications, including local skin reactions and pressure sores, were managed conservatively.ConclusionsSemiflex therapy was feasible in a subset of patients and allowed outpatient treatment. However, maintaining vacuum and achieving long-term fistula closure remains challenging. While Semiflex may have a role in perianal fistula management, further research is needed to refine patient selection and optimize its application.
C1 [Pronk, A. J. M.; Van Oostendorp, J. Y.; Buskens, C. J.; Bemelman, W. A.] Univ Amsterdam, Med Ctr, Dept Surg, Locat VUMC, De Boelelaan 1117, NL-1081HV Amsterdam, Netherlands.
   [Van Oostendorp, J. Y.; Han-Geurts, I. J. M.] Proctos Kliniek, Dept Surg, Bilthoven, Netherlands.
   [Madelska, S.] Semiflex Dome Syst Ltd, Poznan, Poland.
C3 University of Amsterdam
RP Pronk, AJM; Bemelman, WA (通讯作者)，Univ Amsterdam, Med Ctr, Dept Surg, Locat VUMC, De Boelelaan 1117, NL-1081HV Amsterdam, Netherlands.
EM a.pronk@amsterdamumc.nl; w.a.bemelman@amsterdamumc.nl
RI Bemelman, Wilhelmus/AAA-1635-2021
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NR 13
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD DEC 8
PY 2025
VL 30
IS 1
AR 7
DI 10.1007/s10151-025-03240-1
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA P3292
UT WOS:001633474300001
PM 41359090
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Koenig, V
   Christ, A
   Monai, M
   Andreas, M
   Zimpfer, D
   Happak, W
   Werner, P
AF Koenig, Viktoria
   Christ, Alexandra
   Monai, Maximilian
   Andreas, Martin
   Zimpfer, Daniel
   Happak, Wolfgang
   Werner, Paul
TI When Rewiring Fails-The Enduring Role of the Pectoralis Major Flap in
   Sternal Wound Reconstruction
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE deep sternal wound infection (DSWI); cardiac surgery; pectoralis major
   flap; sternal dehiscence
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAPS; MEDIAN STERNOTOMY; OMENTAL FLAP;
   RISK-FACTORS; INFECTION; COMPLICATIONS; MEDIASTINITIS; MANAGEMENT
AB Background: Deep sternal wound infections (DSWIs) remain a serious complication after median sternotomy, often requiring complex wound management strategies. While modern approaches include vacuum-assisted closure (VAC) and plating techniques, the pedicled pectoralis major muscle flap (PMF) continues to play a pivotal role in surgical reconstruction, especially in cases with sternal destruction or osteomyelitis. Methods: In this retrospective single-centre analysis, 166 patients with DSWI following cardiac surgery were reviewed. Clinical data, comorbidities, laboratory parameters, and surgical management were evaluated. Logistic regression was performed to assess predictors for reinfection and need for reoperation. Results: Initial wound revision was most frequently performed using sternal rewiring (60.2%), followed by reconstruction with a pectoralis major flap (33.7%). Despite initial surgical treatment, 27.1% of patients developed post-revision wound healing disturbances, and 24.1% ultimately required a second surgical intervention. Among second-time procedures, VAC therapy (32.5%) and PMF reconstruction (20.0%) were the most common approaches. Reinfection was significantly associated with higher preoperative EuroSCOREs (p = 0.044), while initial rewiring carried a higher risk of treatment failure compared to the pectoralis major flap (p = 0.0024). Conclusions: In the setting of sternal destruction or osteomyelitis, the pectoralis major muscle flap remains a fast, effective, and robust solution. Despite its long-standing use, it continues to offer excellent vascularized coverage and infection control in complex DSWI cases.
C1 [Koenig, Viktoria; Christ, Alexandra; Monai, Maximilian; Happak, Wolfgang] Med Univ Vienna, Div Plast, Aesthet & Reconstruct Surg, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
   [Andreas, Martin] Med Univ Graz, Div Cardiac Surg, Neue Stiftingtalstr 6, A-8010 Graz, Austria.
   [Zimpfer, Daniel; Werner, Paul] Med Univ Vienna, Div Cardiac Surg, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
C3 Medical University of Vienna; Medical University of Graz; Medical
   University of Vienna
RP Koenig, V (通讯作者)，Med Univ Vienna, Div Plast, Aesthet & Reconstruct Surg, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM viktoria.koenig@meduniwien.ac.at; alexandra.christ@meduniwien.ac.at;
   n11927646@students.meduniwien.ac.at; dr.andreas@me.com;
   daniel.zimpfer@meduniwien.ac.az;
   wolfgang.happak2@wienerneustadt.lknoe.at; paul.werner@meduniwien.ac.at
RI ; Zimpfer, Daniel/AAQ-9805-2021; Christ, Alexandra/LRG-6798-2024
OI Andreas, Martin/0000-0003-4950-5432; Koenig,
   Viktoria/0009-0006-9237-0683; Werner, Paul/0000-0003-0925-6160; Christ,
   Alexandra/0000-0001-6827-4110
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NR 39
TC 1
Z9 1
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV 26
PY 2025
VL 14
IS 23
AR 8376
DI 10.3390/jcm14238376
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q8536
UT WOS:001635005800001
PM 41375679
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, KY
   Liu, P
AF Li, Keya
   Liu, Peng
TI Clinical Efficacy of Combined Internal and External Fixation with
   Nanosilver Dressing and Vacuum Closure for Gustilo Type I/II Open Tibial
   Fractures
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID PRESSURE WOUND THERAPY; SILVER NANOPARTICLES; ASSISTED CLOSURE;
   INFECTION-RATE; ACTIVE SILVER; COMPLICATIONS; MANAGEMENT; OUTCOMES
AB Gustilo type I and II open tibial fractures (OTFs) are associated with significant soft tissue injury and a high risk of infection, often resulting in prolonged healing and postoperative complications when treated using conventional internal or external fixation. This study introduces a clinically validated approach that integrates nanosilver antibacterial dressing (NSAD) and vacuum-assisted closure (VAC) with closed reduction and intramedullary nail fixation (CRINF) to improve wound and fracture healing outcomes. A total of 300 patients with Gustilo type I/II OTFs were enrolled and randomly assigned into three groups (n = 100 per group): Group 1 received CRINF with conventional wound care, Group 2 received CRINF with VAC, and Group 3 received CRINF with NSAD and VAC. Clinical outcomes, including infection rate, wound and fracture healing time, hospital stay, medical cost, and postoperative pain, were compared among the groups using chi-square and ANOVA tests, with significance defined as p < 0.05. Group 3 exhibited the lowest complication rate and the most favorable recovery profile, with an average wound healing time of 41 days and a fracture healing time of 7.2 months, both significantly shorter than in the control groups (p < 0.05). The wound and fracture healing rates were 97% and 94%, respectively, while patients experienced shorter hospital stays (10-15 days), lowertotal medical costs (similar to 1500 yuan), and reduced pain levels. These findings demonstrate that combining NSAD and VAC with CRINF offers an effective and safe clinical protocol for managing Gustilo type I and II OTFs, substantially reducing postoperative complications and accelerating recovery.
C1 [Li, Keya; Liu, Peng] Hengshui Peoples Hosp, Dept Orthoped & Traumatol, Hengshui, Peoples R China.
RP Li, KY (通讯作者)，Hengshui Peoples Hosp, Dept Orthoped & Traumatol, Hengshui, Peoples R China.
EM liKeya1234@163.com
RI Li, Keya/PFJ-2068-2025
FU Key R&D Program of Hengshui City
FX This study is supported by the Key R&D Program of Hengshui City (Project
   Name: Clinical Study on the Efficacy of Negative Pressure Closed
   Drainage (VAC) Combined with Internal and External Fixation in the
   Treatment of Open Tibial Fractures) .
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   Tian J, 2007, CHEMMEDCHEM, V2, P129, DOI 10.1002/cmdc.200600171
   Van Praet KM, 2022, INNOVATIONS, V17, P491, DOI 10.1177/15569845221131534
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NR 34
TC 0
Z9 0
U1 1
U2 2
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD NOV
PY 2025
IS 225
AR e69394
DI 10.3791/69394
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Q8901
UT WOS:001635042300022
PM 41359595
DA 2026-07-24
ER
PT J
AU Barzilay, O
   Gefen, A
AF Barzilay, Ofek
   Gefen, Amit
TI Be there or be square: Should we adopt non-rectangular dressing shapes
   in single-use negative pressure wound therapy?
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Dressing design and shape optimization; Wound healing biomechanics;
   Computational finite element modeling and simulations; Mechanobiology in
   wound care; Skin and subdermal tissue stress concentrations
ID VACUUM-ASSISTED CLOSURE; TISSUE LOADS
AB Background: Single-use negative-pressure wound therapy (suNPWT) dressings for closed surgical incisions are predominantly rectangular, despite long-time evidence from biomechanics that sharp or small-radius corners generate localized stress concentrations in underlying tissues. Optimizing dressing geometry and stiffness distribution may reduce the peri-incisional stress concentrations and improve closure. Objectives: To determine how dressing shape and regional stiffness variations influence the peri-wound skin stresses and stress concentrations and the incision closure biomechanics under a negative pressure level of-125 mmHg. Methods: A validated three-dimensional finite element model of a sutured midline incision was developed. Five homogeneous dressing shapes (rectangular, circular, elliptical, stadium, and dome) of identical contact area and material properties were compared for reduction in peak lateral skin stresses (Delta S). The best-performing dressing shape underwent further testing in eight stiffness configurations (homogeneous, or with stiffer/softer peripheral regions in symmetric or axisymmetric patterns). The lateral displacement of the peri-wound skin was used as a measure for the closure work. A sensitivity analysis was conducted on chosen model variants for broader transferability and for exploring potential covariance between dressing shape and material properties. Results: Among the homogeneous dressing shapes, the circular dressing achieved the greatest stress reduction (Delta S = 2.9 %) versus the rectangular control (0.9 %). In the circular form, incorporating a stiffer peripheral symmetric ring around a softer core improved performance (Delta S = 3.2 %) while maintaining substantial lateral displacement (3.35 mm), achieving an optimal combination of stress relief with closure assistance. A fully stiff homogeneous dressing maximized the Delta S (6.5 %) but provided negligible closure support, whereas a fully soft dressing behaved conversely. The sensitivity analysis did not change these quantitative rankings across the studied model variants. Conclusions: Eliminating sharp or small-radius geometric discontinuities and tuning the regional stiffness can markedly attenuate peri-incisional stresses without compromising the contribution of the dressing to the closure work. Circular suNPWT dressings with a peripheral stiffer ring offer a biomechanically superior, manufacturable alternative to conventional rectangular designs, warranting further pre-clinical and clinical evaluations.
C1 [Barzilay, Ofek; Gefen, Amit] Tel Aviv Univ, Fac Engn, Sch Biomed Engn, Tel Aviv, Israel.
   [Gefen, Amit] Univ Ghent, Univ Ctr Nursing & Midwifery, Dept Publ Hlth & Primary Care, Skin Integr Res Grp SKINT, Ghent, Belgium.
   [Gefen, Amit] Hasselt Univ, Dept Math & Stat, Fac Sci, Hasselt, Belgium.
   [Gefen, Amit] Hasselt Univ, Data Sci Inst, Fac Sci, Hasselt, Belgium.
C3 Tel Aviv University; Ghent University; Ghent University Hospital;
   Hasselt University; Hasselt University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Herbert J Berman Chair Vasc Bioengn, Sch Biomed Engn,Biomed Engn, IL-69978 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
OI Gefen, Amit/0000-0002-0223-7218
FU Israeli Ministry of Innovation, Science and Technology: Breakthrough
   Research Program [1001702603]
FX This work was partially supported by the Israeli Ministry of Innovation,
   Science and Technology: Breakthrough Research Program Grant no.
   1001702603, awarded to Professor Amit Gefen in 2023.
CR Adie GC, United States patent, Patent No. [2015;9, 20159]
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NR 25
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2026
VL 35
IS 1
AR 100977
DI 10.1016/j.jtv.2025.100977
EA DEC 2025
PG 10
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA S8008
UT WOS:001636957400001
PM 41351949
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Kratzer, SM
   Kümmerl, L
   Arkudas, A
   Horch, RE
AF Kratzer, Simon M.
   Kummerl, Luca
   Arkudas, Andreas
   Horch, Raymund E.
TI The Role of Topical Negative Pressure Therapy/Vacuum Therapy in
   Orthoplastic Surgery: NPWT, NPWTi-d and ciNPT
SO HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE
LA German
DT Review
DE Wundkonditionierung; Extremit & auml;tenrekonstruktion; Orthoplastische
   Chirurgie; wound conditioning; limb reconstruction; orthoplastic
   surgery; NPWT; ciNPT; NPWTid
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; CONSENSUS STATEMENT;
   PERIPHERAL-NERVES; TRAUMATIC WOUNDS; INSTILLATION; RECONSTRUCTION;
   MANAGEMENT; RECOMMENDATIONS; MICROSURGERY
AB Background Today, wounds of the extremities are often initially treated with localised negative pressure therapy (vacuum therapy) before bone and soft tissue reconstruction is performed. The aim is to preserve the limb and restore function and quality of life. The interdisciplinary collaboration in the treatment of neurovascular pathologies, reconstruction, and rehabilitation is known as orthoplastic reconstruction. Methods This paper outlines the milestones that have led to the development of the orthoplastic concept in limb reconstruction. In addition, the fundamental principles of modern treatment strategies, including wound bed conditioning with vacuum therapy, are discussed on the basis of relevant literature and illustrated with representative examples. Results A review of the literature shows that orthoplastic surgery developed at different times in different countries. It was only with the advent of modern techniques for skeletal stabilisation and soft tissue reconstruction that interdisciplinary concepts, including topical vacuum therapy, found their way into everyday clinical practice. Advantages of the orthoplastic approach include faster stabilisation, early soft tissue coverage, shorter hospitalisation times, reduced complication rates, and better long-term functional outcomes. Conclusion Today, localised negative pressure therapy is an indispensable tool in the orthoplastic approach. Close collaboration between plastic-reconstructive and trauma-orthopaedic surgery is essential for the timely management of reconstructive limb injuries. This approach has proven effective at specialised centres in determining the optimal time for reconstruction and improving outcomes. The earlier assumption that amputation is often more favourable has been refuted by successful orthoplastic reconstructions achieving long-term limb preservation. Today, the aim is to preserve the limb whenever possible.
C1 [Kratzer, Simon M.; Kummerl, Luca; Arkudas, Andreas; Horch, Raymund E.] Univ Klinikum Erlangen, Plast & Handchirurg Klin, Maximilianspl 2, D-91012 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Kratzer, SM (通讯作者)，Univ Klinikum Erlangen, Plast & Handchirurg Klin, Maximilianspl 2, D-91012 Erlangen, Germany.
EM simon.kratzer@uk-erlangen.de
RI Horch, Raymund/H-8128-2019; Arkudas, Andreas/AAQ-6745-2021
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NR 70
TC 0
Z9 0
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0722-1819
EI 1439-3980
J9 HANDCHIR MIKROCHIR P
JI Handchir. Mikrochir. Plast. Chir.
PD DEC
PY 2025
VL 57
IS 06
BP 455
EP 464
DI 10.1055/a-2706-0291
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA T4125
UT WOS:001637569100008
PM 41380693
DA 2026-07-24
ER
PT J
AU Wang, L
   Gao, SF
   Jiang, YS
   Chen, P
   Gong, ZH
AF Wang, Lu
   Gao, Sheng-Feng
   Jiang, Ya-Su
   Chen, Peng
   Gong, Zhen-Hua
TI Study on the effect of negative pressure occlusion drainage combined
   with silver ion dressing on inflammatory factors (IL-6, TNF-α) and
   healing effect of diabetic foot ulcer
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetic foot; negative pressure closed drainage; silver ion dressings;
   inflammatory factors; ulcers
ID IMPACT
AB Background: Diabetic foot ulcers impair quality of life and prognosis in diabetes. IL-6 and TNF-alpha regulate wound healing through inflammation. Although negative pressure wound therapy and silver dressings aid chronic wound repair, their combined efficacy in DFUs remains understudied. Objective: This study aimed to assess how negative pressure occlusion drainage combined with silver ion dressing affects inflammatory cytokine levels (IL-6, TNF-alpha) and wound healing in patients with diabetic foot ulcer. Methods: This study included 78 DFU patients treated with NPWT plus silver dressings (February 2023-April 2025). Serum IL-6 and TNF-alpha levels were measured at baseline, day 14, and day 30 post-treatment. Results: The findings indicated that IL-6 and TNF-alpha levels were significantly reduced at 14- and 30-days post-treatment compared to pre-treatment levels (P < 0.001), and the findings indicated a notable reduction in the wound area, with a healing duration of 19.49 +/- 4.18 days and granulation tissue appearing in 6.83 +/- 1.85 days. After 30 days of treatment, the healing rate reached 93.59%. The incidence of adverse reactions was low, 6.41%, and most of them were mild skin itching, nausea and vomiting, and a small amount of diarrhea. Conclusion: Negative pressure occlusion drainage combined with silver ion dressing has potential advantages in reducing inflammatory response and promoting the healing of diabetic foot ulcers, which is worthy of clinical application. In the future, multicenter randomized controlled trials are needed to further verify its efficacy and safety.
C1 [Wang, Lu; Gao, Sheng-Feng; Jiang, Ya-Su; Chen, Peng; Gong, Zhen-Hua] Nantong First Peoples Hosp, Dept Burn & Plast Surg & Wound Repair, Nantong, Jiangsu, Peoples R China.
C3 Southeast University - China
RP Gong, ZH (通讯作者)，Nantong First Peoples Hosp, Dept Burn & Plast Surg & Wound Repair, Nantong, Jiangsu, Peoples R China.
EM wangluu1208@163.com
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NR 28
TC 0
Z9 0
U1 5
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 28
PY 2025
VL 16
AR 1689232
DI 10.3389/fendo.2025.1689232
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA T5237
UT WOS:001637680300001
PM 41393293
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhou, LR
   Li, C
   Guan, XH
   Xie, J
   Lin, WL
   Wu, BM
   Chen, Y
   Huang, JW
   Gong, LJ
AF Zhou, Linrong
   Li, Cui
   Guan, Xuehong
   Xie, Jing
   Lin, Wanli
   Wu, Bomeng
   Chen, Ying
   Huang, Jiawei
   Gong, Lanjuan
TI Study on the application of modified negative pressure wound therapy
   with instillation in cervical anastomotic leakage after oesophageal
   cancer surgery
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE negative-pressure wound therapy with instillation; oesophageal cancer;
   cervical anastomotic leakage; odour management; negative-pressure wound
   therapy
AB <bold>Aims:</bold> This study aims to explore the feasibility and safety of modified negative-pressure wound therapy with instillation (NPWTi) for the treatment of cervical anastomotic leakage (CAL) after oesophageal cancer surgery. <bold>Methods:</bold> A retrospective analysis was conducted on 17 patients who developed CAL after oesophageal cancer surgery and received modified NPWTi treatment at our hospital from 2021 to 2024. The primary outcome was the time to healing, defined as the number of days from the initiation of modified NPWTi to complete fistula closure. Secondary outcomes included wound odour improvement and patient comfort. <bold>Results:</bold> A total of 17 patient were collected, including 10 men and seven women, with an average age of 73.71 +/- 8.01 years. None received neoadjuvant therapy, and no patients had diabetes; preoperative albumin was 38.77 +/- 3.58 g/L. The occurrence of CAL was noted at 8.88 +/- 3.15 d (95% CI: 7.26 to 10.51 d) post-surgery. The modified treatment was commenced 0-12 d after CAL diagnosis, with the earliest case starting on the day of diagnosis. The mean duration of modified NPWTi was 10.88 +/- 6.54 d (95% CI: 7.52 to 14.25 d). For the primary outcome, the time from treatment initiation to complete healing was 15.00 +/- 7.26 d (95% CI: 11.27 to 18.73 d), with a minimum of five days. No mediastinal or pleural infections related to NPWTi occurred during the treatment. For the secondary outcomes, a significant improvement in wound odour was observed following the administration of the modified NPWTi (P<0.001), with an improvement rate of 100% (95% CI: 85-100%). During the treatment, the patients reported feeling comfortable and expressed overall satisfaction. <bold>Conclusion:</bold> Modified NPWTi demonstrated significant efficacy and convenience in treating CAL after oesophageal cancer surgery, benefiting both patients and healthcare providers with good safety profiles, thus warranting broader clinical application.
C1 [Zhou, Linrong; Li, Cui; Guan, Xuehong; Xie, Jing; Lin, Wanli; Wu, Bomeng; Chen, Ying; Huang, Jiawei; Gong, Lanjuan] Gaozhou Peoples Hosp, Dept Thorac Surg, Maoming, Guangdong, Peoples R China.
   [Zhou, Linrong; Li, Cui; Guan, Xuehong; Xie, Jing; Lin, Wanli; Wu, Bomeng; Chen, Ying; Huang, Jiawei; Gong, Lanjuan] Guangdong Oesophageal Canc Inst, Gaozhou Branch, Gaozhou, Peoples R China.
   [Gong, Lanjuan] Gaozhou Peoples Hosp, Nursing Dept, Maoming, Guangdong, Peoples R China.
RP Huang, JW; Gong, LJ (通讯作者)，Gaozhou Peoples Hosp, Dept Thorac Surg, Maoming, Guangdong, Peoples R China.; Huang, JW; Gong, LJ (通讯作者)，Guangdong Oesophageal Canc Inst, Gaozhou Branch, Gaozhou, Peoples R China.; Gong, LJ (通讯作者)，Gaozhou Peoples Hosp, Nursing Dept, Maoming, Guangdong, Peoples R China.
EM hjw15992198147@163.com; gonglanjuan8161@163.com
FU Guangdong Medical Research Fund Project [B2023212]; Guangdong Provincial
   Oesophageal Cancer Research Institute Science and Technology Plan
   Project [M202410]
FX The author(s) declare financial support was received for the research
   and/or publication of this article. This work was supported by the
   Guangdong Medical Research Fund Project in 2023 (B2023212) and the
   Guangdong Provincial Oesophageal Cancer Research Institute Science and
   Technology Plan Project (M202410).
CR Biere SSAY, 2011, DIGEST SURG, V28, P29, DOI 10.1159/000322014
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NR 18
TC 1
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD DEC 1
PY 2025
VL 15
AR 1644593
DI 10.3389/fonc.2025.1644593
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA U8261
UT WOS:001638988400001
PM 41404061
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Clinker, C
   Scaife, J
   Kahan, A
   Cordoba, N
   Russell, KW
   Jones, TW
AF Clinker, Christopher
   Scaife, Jack
   Kahan, Anastasia
   Cordoba, Nicolas
   Russell, Katie W.
   Jones, Trahern W.
TI Salvage of the infected Nuss bar: a protocol and institutional
   experience
SO PEDIATRIC SURGERY INTERNATIONAL
LA English
DT Article
DE Nuss procedure; Implant infection; Pectus excavatum; Hardware salvage;
   Pediatric surgery
ID MINIMALLY INVASIVE REPAIR; PECTUS EXCAVATUM REPAIR; RISK-FACTORS;
   COMPLICATIONS; MANAGEMENT; RAVITCH
AB Background Surgical implant infections often necessitate early hardware removal, complicating patient care. Nuss bars are placed via minimally invasive surgery to correct pectus excavatum. While rare, Nuss bar infections may be salvaged with prolonged antibiotics. However, no standardized protocols exist to guide management and prevent premature removal. Methods This study describes the implementation of a Nuss bar infection salvage protocol. This protocol was developed and implemented for six adolescent patients who underwent minimally-invasive Nuss bar implantations for pectus excavatum and suffered subsequent device-related infection between October 2021 and October 2024. Infection was determined both clinically and intraoperatively and confirmed with positive culture results. Detailed chart review was completed in patients who had infections. Results 221 Nuss procedures were performed during the study period with six patients found to have an implant infection for an infection rate of 2.7%. Infections presented from 9 to 61 days following initial placement, with a median of 26 days. Five of six infections were associated with growth of Staphylococcus aureus. Four of these were methicillin-sensitive, while one was methicillin-resistant. The sixth patient's intraoperative cultures were positive for Pseudomonas aeruginosa. Based on the developed protocol, all patients underwent 2-4 operative washouts and debridement procedures with negative pressure wound therapy between procedures. They were initially treated with broad-spectrum antibiotics and culture-directed antibiotic therapy for a total of 12 weeks. Five of six patients were transitioned to early oral antibiotics at discharge, and one required 12 weeks of intravenous antibiotics due to severe oral aversion. All patients retained their hardware and had no evidence of relapse of infection following completion of their salvage therapy. Conclusions Nuss bar infections are rare. Experience has demonstrated successful salvage with a standardized protocol incorporating 12 weeks of directed antibiotic therapy, serial washouts, and close follow-up, with no relapses of infection.
C1 [Clinker, Christopher; Scaife, Jack; Kahan, Anastasia; Russell, Katie W.] Univ Utah, Dept Surg, Div Pediat Surg, 100 North Mario Capecchi Dr Suite 3800, Salt Lake City, UT 84113 USA.
   [Clinker, Christopher] Univ Calif Davis, Dept Surg, Sacramento, CA 95616 USA.
   [Cordoba, Nicolas; Jones, Trahern W.] Univ Utah, Dept Pediat, Div Pediat Infect Dis, Salt Lake City, UT USA.
C3 Utah System of Higher Education; University of Utah; University of
   California System; University of California Davis; Utah System of Higher
   Education; University of Utah
RP Clinker, C (通讯作者)，Univ Utah, Dept Surg, Div Pediat Surg, 100 North Mario Capecchi Dr Suite 3800, Salt Lake City, UT 84113 USA.; Clinker, C (通讯作者)，Univ Calif Davis, Dept Surg, Sacramento, CA 95616 USA.
EM cclinker@ucdavis.edu
RI Scaife, Jack/JDD-9282-2023
CR Albano M, 2019, ANTIMICROB AGENTS CH, V63, DOI 10.1128/AAC.00959-19
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-0358
EI 1437-9813
J9 PEDIATR SURG INT
JI Pediatr. Surg. Int.
PD DEC 15
PY 2025
VL 42
IS 1
AR 39
DI 10.1007/s00383-025-06275-5
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA X0331
UT WOS:001640201000001
PM 41396327
DA 2026-07-24
ER
PT J
AU Ebeid, I
   Ebeid, A
   Shalaby, A
   Noureldeen, IM
   Essa, A
   Elmenawi, KA
AF Ebeid, Ibrahim
   Ebeid, Ahmed
   Shalaby, Ahmed
   Mohamed Noureldeen, Ibrahim
   Essa, Ali
   A. Elmenawi, Khaled
TI Negative pressure wound therapy for the prevention of surgical site
   infections in orthopedic and trauma surgery: a systematic review and
   meta-analysis of RCTs
SO JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
LA English
DT Review
DE Orthopedics; Surgical site infections (SSIs); Negative pressure wound
   therapy (NPWT); Meta-analysis
ID KNEE ARTHROPLASTY; PRIMARY HIP; DRESSINGS; COMPLICATIONS; DEHISCENCE;
   FRACTURES; INCISIONS
AB BackgroundSurgical site infections (SSIs) are an important postoperative complication in orthopedic surgery, resulting in increased morbidity, prolonged hospital stay, and higher healthcare costs. Negative pressure wound therapy (NPWT) has been proposed to reduce SSIs by facilitating wound healing by increased perfusion, edema reduction, and bacterial control. This systematic review and meta-analysis evaluate the effectiveness of NPWT compared with conventional dressings for prevention of surgical site infections in orthopedic and trauma surgery.MethodsA comprehensive literature search was performed across PubMed, Web of Science, Scopus, and the Cochrane Library in December 2024. Only randomized controlled trials (RCTs) comparing NPWT with CD in patients undergoing joint replacement, trauma surgery, or spine surgery were included. Two independent reviewers conducted data extraction and assessed study quality using the Cochrane Risk of Bias 2 tool. Pooled outcomes were evaluated with odds ratios (ORs) computed for dichotomous variables and mean differences (MDs) for continuous outcomes. Heterogeneity was assessed via the I2 statistic and publication bias through Egger's test.ResultsOverall, 18 RCTs, comprising a total of 4585 patients, were included. Meta-analysis demonstrated that NPWT significantly reduced SSIs (pooled OR 0.64, 95% CI 0.50-0.82; p = 0.0005) and wound dehiscence (pooled OR 0.39, 95% CI 0.23-0.65; p = 0.0003). Additionally, NPWT was associated with a reduction in length of hospital stay by 0.87 days (MD -0.87, 95% CI -1.36 to -0.38; p = 0.0005) and fewer dressing changes compared with conventional methods. The quality of evidence for the primary outcome was rated as moderate based on the GRADE approach.ConclusionsNPWT appears to offer a significant clinical benefit in reducing the incidence of SSIs in orthopedic and trauma surgery. Secondary analyses also demonstrated benefits for surgical wound dehiscence, length of hospital stay, and number of dressing changes. However, the certainty of evidence is moderate, and these findings should be interpreted with caution. Further well-designed, multicenter RCTs are warranted to confirm these benefits, assess long-term outcomes, and evaluate cost-effectiveness.Level of evidence Level I.Registration: CRD42024624188.ConclusionsNPWT appears to offer a significant clinical benefit in reducing the incidence of SSIs in orthopedic and trauma surgery. Secondary analyses also demonstrated benefits for surgical wound dehiscence, length of hospital stay, and number of dressing changes. However, the certainty of evidence is moderate, and these findings should be interpreted with caution. Further well-designed, multicenter RCTs are warranted to confirm these benefits, assess long-term outcomes, and evaluate cost-effectiveness.Level of evidence Level I.Registration: CRD42024624188.ConclusionsNPWT appears to offer a significant clinical benefit in reducing the incidence of SSIs in orthopedic and trauma surgery. Secondary analyses also demonstrated benefits for surgical wound dehiscence, length of hospital stay, and number of dressing changes. However, the certainty of evidence is moderate, and these findings should be interpreted with caution. Further well-designed, multicenter RCTs are warranted to confirm these benefits, assess long-term outcomes, and evaluate cost-effectiveness.Level of evidence Level I.Registration: CRD42024624188.
C1 [Ebeid, Ibrahim; Ebeid, Ahmed; Shalaby, Ahmed; Mohamed Noureldeen, Ibrahim; Essa, Ali] Menoufia Univ, Fac Med, Shibin Al Kawm, Egypt.
   [A. Elmenawi, Khaled] Cleveland Clin, Dept Orthopaed Surg, Cleveland Hts, OH USA.
C3 Egyptian Knowledge Bank (EKB); Menofia University; Cleveland Clinic
   Foundation
RP Ebeid, I (通讯作者)，Menoufia Univ, Fac Med, Shibin Al Kawm, Egypt.
EM IbrahimEbeid@outlook.com
RI Ebeid, Ibrahim/PHO-6101-2026
OI Ebeid, Ibrahim/0009-0002-4264-7518
FU Minufiya University
FX Open access funding provided by The Science, Technology & Innovation
   Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank
   (EKB).
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NR 69
TC 2
Z9 2
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1590-9921
EI 1590-9999
J9 J ORTHOP TRAUMATOL
JI J. Orthop. Traumatol.
PD DEC
PY 2025
VL 26
IS 1
AR 75
DI 10.1186/s10195-025-00889-0
PG 17
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA X7323
UT WOS:001640902300002
PM 41400731
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Davenport, T
   Dirks, R
   Kelso, MR
   Low, M
AF Davenport, Thomas
   Dirks, Ryan
   Kelso, Martha R.
   Low, Mervin
TI CELLULAR, ACELLULAR AND MATRIX-LIKE PRODUCTS (CAMPS) IN PRESSURE
   INJURIES
SO JOURNAL OF WOUND CARE
LA English
DT Article
ID DIABETIC FOOT ULCERS; SKIN SUBSTITUTES; EXTRACELLULAR-MATRIX;
   SURGICAL-TREATMENT; WOUND THERAPY; MANAGEMENT; FACILITIES; EFFICACY;
   IMPACT; SAFETY
AB The high prevalence and recurrence of pressure injuries (PIs) require new treatment strategies. The goals of PI treatment and research should be holistic, encompassing quality of life, symptom control, patient-directed goals of care and survival, as well as cure. Cellular, acellular and matrix-like products (CAMPs) are advanced wound-care tools that promote innate healing processes, such as stimulating fibroblast activity, granulation tissue formation and keratinocyte migration. CAMPs have been shown to be safe and effective in full-thickness PIs and other hard-to-heal wounds. Indications for CAMPs should include early application in complex wounds, multiple comorbidities or impaired healing capacity, with or without exposed deep structures. Patient selection should consider absolute and relative contraindications for CAMPs, as well as differential diagnoses for PIs, such as skin failure and malignant or atypical wounds. Patients treated with CAMPs require optimisation of offloading, mobility and tissue perfusion, along with addressing nicotine use and polypharmacy, as well as skin protection, nutrition and psychosocial support. Application of CAMPs must be preceded by wound-bed preparation encompassing tissue debridement, inflammation/infection control, moisture management and optimisation of patient and social factors. CAMPs should be applied in a clean environment following instructions for use, potentially supported by negative pressure wound therapy. Use of CAMPs requires ongoing documentation and re-assessment of treatment efficacy and quality of life, with onward referral for osteomyelitis, fistulas or other arterial disease. CAMPs use should be based in multidisciplinary collaboration and supported by patient and professional education. The appropriate use of CAMPs in PIs should be applied across all payors and relevant sites of service. Research on CAMPs in PIs should make wider use of real-world data to support the limited number and narrow scope of randomised control trials.
C1 [Davenport, Thomas] New York Plast Surg Grp, New York, NY 10028 USA.
   [Dirks, Ryan] United Wound Healing, Puyallup, WA USA.
   [Kelso, Martha R.] Wound Care Plus LLC, Blue Springs, MO USA.
   [Low, Mervin] Newport Wound, Newport Beach, CA USA.
RP Davenport, T (通讯作者)，New York Plast Surg Grp, New York, NY 10028 USA.
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NR 85
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2025
VL 34
IS 12
SU D
PG 20
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AB6NS
UT WOS:001644293600001
DA 2026-07-24
ER
PT J
AU Zeng, Y
   Tu, JJ
   Qin, JC
AF Zeng, Ying
   Tu, Jianjian
   Qin, Jichao
TI The mechanism by which negative pressure wound therapy promotes wound
   healing
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Negative pressure wound therapy; Healing; Wound
ID VACUUM-ASSISTED CLOSURE; INFECTED WOUNDS; CYTOKINE LEVELS; TISSUE;
   GROWTH; MATRIX; SILVER; SERUM
AB Negative pressure wound therapy (NPWT) has demonstrated substantial advantages in a variety of clinical settings, including the management of acute and chronic wounds, open injuries with exposed bone, nerves, or tendons, and implant-associated infections in orthopedics. Although numerous studies have reported the beneficial effects of NPWT in controlling wound infections and infections related to orthopedic implants, the underlying molecular and cellular mechanisms remain incompletely understood and require further investigation. Given its widespread clinical use, a comprehensive understanding of the biological effects of NPWT is essential to ensuring its rational and optimized application in clinical practice. This review summarizes the potential mechanisms through which NPWT facilitates wound healing and provides insights to inform both clinical use and future research.
C1 [Zeng, Ying] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Nursing, Hangzhou 310003, Peoples R China.
   [Tu, Jianjian] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Surg, Wuhan 430030, Peoples R China.
   [Qin, Jichao] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Gastrointestinal Surg, Hangzhou 310003, Peoples R China.
C3 Zhejiang University; Huazhong University of Science & Technology;
   Zhejiang University
RP Qin, JC (通讯作者)，Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Gastrointestinal Surg, Hangzhou 310003, Peoples R China.
EM jcqin2024@zju.edu.cn
OI Qin, Jichao/0000-0002-2961-7624
FU National Natural Science Foundation of China [82173368, 82372995];
   Nursing research project of the first hospital of Zhejiang University
   [2023ZYHL02 , 2025ZYHL25]; Zhejiang Provincial Medical and Health
   Science and Technology Plan [2024KY1006]; Zhejiang Provincial Science
   and technology program of traditional Chinese Medicine [2024ZL552];
   General scientific research projects of Zhejiang Provincial Department
   of Edu-cation (Natural Sciences) [Y202353869]
FX This work was supported by the National Natural Science Foundation of
   China (Nos. 82173368, 82372995) , the Nursing research project of the
   first hospital of Zhejiang University (2023ZYHL02 , 2025ZYHL25) , the
   Zhejiang Provincial Medical and Health Science and Technology Plan
   (2024KY1006) , the Zhejiang Provincial Science and technology program of
   traditional Chinese Medicine (2024ZL552) , and the General scientific
   research projects of Zhejiang Provincial Department of Edu-cation
   (Natural Sciences) (Y202353869) .
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NR 60
TC 2
Z9 2
U1 4
U2 4
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2026
VL 35
IS 1
AR 100982
DI 10.1016/j.jtv.2025.100982
EA DEC 2025
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA AD3EL
UT WOS:001645420000001
PM 41418450
OA hybrid
DA 2026-07-24
ER
PT J
AU Cheng, H
   Li, XJ
   Li, XY
   Bai, Y
   Zhang, W
   Zhao, B
   Yang, T
   Li, P
   Yao, WD
AF Cheng, Hui
   Li, Xiaojing
   Li, Xinyi
   Bai, Yun
   Zhang, Wei
   Zhao, Boao
   Yang, Tao
   Li, Ping
   Yao, Wende
TI Extensive Nevus Comedonicus Treated by Comb Flap Reconstruction, Super
   Tension-Relieving Sutures, and Vacuum Sealing Drainage: A Case Report
SO CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
LA English
DT Article
DE nevus comedonicus; whole-exome sequencing; surgical management; super
   tension-relieving sutures; vacuum sealing drainage
AB Purpose: There are few reports on the comprehensive surgical management of extensive nevus comedonicus, and the genetic mechanism of this rare disease is not yet fully understood. Patients and Methods: We report a case of a 38-year-old woman with extensive nevus comedonicus, refractory to multiple medical treatments. She underwent comb flap reconstruction combined with super tension-relieving sutures and vacuum sealing drainage. In addition, whole-exome sequencing was performed on the lesional tissue samples. Results: Nevus comedonicus was confirmed by physical and histopathological examination. Postoperative recovery was uneventful, and the patient was satisfied with the efficacy. Furthermore, no rare or deleterious mutations were detected in NEK9, FGFR2, ABCA12, or KRT10. Conclusion: Comprehensive surgical intervention is a viable therapeutic option for extensive nevus comedonicus refractory to medical management. Further investigation into the underlying genetic mechanisms of this disease is warranted.
C1 [Cheng, Hui; Li, Xiaojing; Li, Xinyi; Bai, Yun; Zhang, Wei; Zhao, Boao; Yang, Tao; Li, Ping; Yao, Wende] Anhui Med Univ, Affiliated Hosp 1, Dept Plast Surg, Hefei, Anhui, Peoples R China.
C3 Anhui Medical University
RP Yao, WD (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Plast Surg, Hefei, Anhui, Peoples R China.
EM yaowende2020@126.com
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NR 10
TC 0
Z9 0
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7015
J9 CLIN COSMET INV DERM
JI CLIN. COSMET. INVESTIG. DERMATOL.
PY 2025
VL 18
BP 3533
EP 3536
DI 10.2147/CCID.S574723
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AD8SQ
UT WOS:001645795600001
PM 41450453
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Alayed, H
   Hsu, AHS
   Wu, KT
   Wu, CT
   Lin, PC
   Kuo, FC
AF Alayed, Hisham
   Hsu, Allen Herng Shouh
   Wu, Kuan-Ting
   Wu, Cheng-Ta
   Lin, Po-Chun
   Kuo, Feng-Chih
TI The effect of post-operative continuous negative pressure therapy after
   debridement, antibiotics, and implant retention for acute periprosthetic
   joint infection
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Periprosthetic joint infection; DAIR; Continuous negative pressure
   therapy; Total knee arthroplasty; Total hip arthroplasty
ID VACUUM-ASSISTED CLOSURE; HIP-ARTHROPLASTY; TREATMENT OPTION;
   RISK-FACTORS; IRRIGATION; DAIR; EXCHANGE; OUTCOMES; SUCCESS; MANAGEMENT
AB BackgroundAcute periprosthetic joint infection (PJI) is a serious complication after total knee and hip replacement, with varying success rates in its management using debridement, antibiotics, and implant retention (DAIR). We hypothesize that the application of post-operative continuous negative pressure therapy (CNPT) can improve the success rate of DAIR in the treatment of acute knee and hip PJI.MethodsIn this retrospective study from October 2018 to December 2022, 62 patients diagnosed with acute PJI were divided into two groups: 24 patients treated with DAIR and CNPT, and 38 patients treated with DAIR alone. The groups were comparable in terms of patient characteristics, organism profile, and clinical findings. The primary outcome was treatment failure based on the Delphi consensus criteria for 1-year follow up. The statistical analysis involved univariate and multivariate regression.ResultsAfter a year of follow-up, the CNPT group had a significantly lower treatment failure rate (25%) compared to the control group (55.3%, p = 0.019). After controlling the confounding factors, the use of CNPT remained as a significant factor with a lower OR (adjusted OR: 0.13; 95% CI 0.02-0.86, p = 0.034), indicating its potential effectiveness in improving DAIR outcomes.ConclusionThe study suggests that CNPT could substantially enhance the success rate of DAIR in treating acute PJI. This intervention may represent a significant advancement in post-operative care, potentially reducing the failure rate of DAIR treatment and improving patient outcomes.
C1 [Alayed, Hisham; Hsu, Allen Herng Shouh; Wu, Kuan-Ting; Wu, Cheng-Ta; Lin, Po-Chun; Kuo, Feng-Chih] Kaohsiung Chang Gung Mem Hosp, Dept Orthopaed Surg, 123 Dapi Rd, Kaohsiung 833, Taiwan.
   [Alayed, Hisham] Al Basheer Hosp, Amman, Jordan.
   [Wu, Kuan-Ting; Wu, Cheng-Ta; Kuo, Feng-Chih] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Kuo, Feng-Chih] Cheng Shiu Univ, Ctr Gen Educ, Kaohsiung, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Cheng Shiu
   University
RP Kuo, FC (通讯作者)，Kaohsiung Chang Gung Mem Hosp, Dept Orthopaed Surg, 123 Dapi Rd, Kaohsiung 833, Taiwan.; Kuo, FC (通讯作者)，Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.; Kuo, FC (通讯作者)，Cheng Shiu Univ, Ctr Gen Educ, Kaohsiung, Taiwan.
EM drhesham87@gmail.com; alking0061@cgmh.org.tw; Ktwu77@gmail.com;
   oliverwu429@cgmh.org.tw; u301117@cgmh.org.tw; fongchikuo@cgmh.org.tw
RI 郭, 峯志/W-3327-2019
FU Kaohsiung Chang Gung Memorial Hospital, Taiwan [CORPG8M0011]
FX We acknowledge and thank the Biostatistics Center at Kaohsiung Chang
   Gung Memorial Hospital and Mr. Chun-Sheng Lin for their statistical
   work. We acknowledge Vanessa Hsieh for her assistance in creating the
   illustration for negative pressure wound therapy. This work was
   partially supported by Kaohsiung Chang Gung Memorial Hospital, Taiwan
   (Grant numbers: CORPG8M0011 to FC Kuo).
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NR 39
TC 0
Z9 0
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD DEC
PY 2025
VL 20
IS 1
AR 1081
DI 10.1186/s13018-025-06355-1
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA AH1AN
UT WOS:001647979300001
PM 41437388
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Nghia, PT
   Son, TT
   Thúy, TTH
   Trong, NH
   Nam, BP
AF Nghia, Phan Tuan
   Thiet Son, Tran
   Thuy, Ta Thi Hong
   Trong, Nguyen Huu
   Nam, Bang Phuong
TI Free Skin Anterolateral Thigh Flap and Vacuum-Assisted Closure Therapy
   for Reconstruction of Snakebite-Induced Complex Hand Defects
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE snakebite; skin necrosis; VAC therapy; ALT flap; hand reconstruction
ID MANAGEMENT
AB Introduction: Cobra (Naja species) envenomation in tropical regions like Vietnam frequently leads to severe hand tissue necrosis, creating complex defects that challenge conventional reconstruction. This study evaluates a staged approach combining vacuumassisted closure (VAC) therapy with free anterolateral thigh (ALT) flap for these challenging injuries. Methods: Eleven patients with extensive hand defects involving skin and/or tendon due to cobra envenomation were included. Following surgical debridement, VAC therapy was applied to prepare the wound bed. Subsequently, definitive reconstruction was performed using tailored ALT flaps, which included fasciocutaneous or thinned configurations depending on defect complexity. Postoperative evaluation included flap viability, range of motion (ROM), and complication assessment. Results: The mean duration of VAC therapy was 11.5 +/- 4.2 days. Eleven ALT flaps with an average dimension of 14.5x7.0 cm were harvested. Flap thinning was performed in eight cases (72.7%), achieving a mean final thickness of 4.6 +/- 1.3 mm. Eight flaps (72.7%) were used to cover defects spanning both digital and dorsal or palmar subunits. Over a mean follow-up of 15.3 months, patients with digital reconstruction achieved a functional ROM at the metacarpophalangeal joint, with 0 degrees of extension and up to 60 degrees of flexion. The main issue was flap bulkiness; no donor-site morbidity was observed. Conclusion: A staged approach combining VAC therapy for wound bed preparation and subsequent reconstruction with a free ALT flap is a safe and effective strategy for managing complex hand defects resulting from cobra bites. This method facilitates optimal wound conditions and provides versatile, well-vascularized tissue coverage, thereby promoting functional hand recovery.
C1 [Nghia, Phan Tuan; Thiet Son, Tran; Thuy, Ta Thi Hong; Nam, Bang Phuong] Hanoi Med Univ, Dept Plast & Reconstruct Surg, 1 Ton That Tung St, Hanoi, Vietnam.
   [Nghia, Phan Tuan; Thiet Son, Tran; Thuy, Ta Thi Hong; Trong, Nguyen Huu] Bach Mai Hosp, Dept Plast Reconstruct & Aesthet Surg, Hanoi, Vietnam.
   [Nghia, Phan Tuan; Thiet Son, Tran; Nam, Bang Phuong] VinUniversity, Vinmec Int Hosp, Dept Plast Reconstruct & Aesthet Surg, Hanoi, Vietnam.
C3 Hanoi Medical University; VinUniversity
RP Nghia, PT (通讯作者)，Hanoi Med Univ, Dept Plast & Reconstruct Surg, 1 Ton That Tung St, Hanoi, Vietnam.
EM phantuannghia@hmu.edu.vn
RI ; Phan Tuấn, Nghĩa/IXN-9615-2023; Thiet Son, Tran/KHV-3202-2024
OI Đặng, Phương Nam/0009-0009-8827-544X; Phan Tuấn,
   Nghĩa/0000-0002-8709-6169; Thiet Son, Tran/0000-0001-6739-1059
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NR 25
TC 0
Z9 0
U1 3
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2025
VL 21
BP 1847
EP 1853
DI 10.2147/TCRM.S560853
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA AL6OH
UT WOS:001651057100001
PM 41477434
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Katsaros, I
   Papadakos, SP
   Despotidis, M
   Koutsoumpas, A
   Schizas, D
AF Katsaros, Ioannis
   Papadakos, Stavros P.
   Despotidis, Markos
   Koutsoumpas, Andreas
   Schizas, Dimitrios
TI Endoscopic vacuum-assisted closure as a first-line treatment for
   post-esophagectomy anastomotic leaks: A paradigm shift in management
SO WORLD JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Review
DE Esophageal cancer; Esophagectomy; Anastomotic leak; Endoscopic
   vacuum-assisted closure; Endoscopic vacuum therapy
ID THERAPY; LEAKAGES; STENT; LIFE
AB Post-esophagectomy anastomotic leak (AL) is a severe complication following esophagectomy, contributing to increased morbidity, prolonged hospitalization, and a significant risk of mortality. Endoscopic vacuum-assisted closure (EndoVac) has emerged as a promising first-line treatment, offering a highly effective approach for managing post-esophagectomy AL. EndoVac therapy utilizes continuous negative pressure within the esophageal lumen or mediastinal cavity, promoting granulation tissue formation, accelerating wound healing, and enhancing AL closure rates. Compared to stenting, EndoVac provides distinct advantages, including superior adaptability to varying leak sizes and locations, enhanced secretion drainage, and lower rates of reintervention. Clinical studies have demonstrated higher success rates, decreased post-intervention complications, and shorter hospital stays. Despite its advantages, challenges persist in patient selection, procedural expertise, and accessibility. EndoVac application requires experienced endoscopic teams and multidisciplinary expertise, which is best achieved in high-volume centers with specialized care. Variability in EndoVac protocols necessitate further refinement and standardization to optimize treatment outcomes. The integration of EndoVac into standardized treatment guidelines holds promise for improving patient outcomes and redefining the management approach for this challenging postoperative complication.
C1 [Katsaros, Ioannis; Despotidis, Markos; Schizas, Dimitrios] Natl & Kapodistrian Univ Athens, Dept Surg 1, Agiou Thoma 17, Athens 11527, Attiki, Greece.
   [Papadakos, Stavros P.; Koutsoumpas, Andreas] Natl & Kapodistrian Univ Athens, Dept Gastroenterol 1, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens
RP Katsaros, I; Schizas, D (通讯作者)，Natl & Kapodistrian Univ Athens, Dept Surg 1, Agiou Thoma 17, Athens 11527, Attiki, Greece.
EM gikats.md@gmail.com
RI Katsaros, Ioannis/AHI-2537-2022; SCHIZAS, DIMITRIOS/Z-3323-2019;
   Papadakos, Stavros/AFF-9357-2022
OI Papadakos, Stavros/0000-0003-1583-1125
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NR 42
TC 0
Z9 0
U1 0
U2 0
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1948-9366
J9 WORLD J GASTRO SURG
JI World J. Gastrointest. Surg.
PD DEC 27
PY 2025
VL 17
IS 12
AR 113305
DI 10.4240/wjgs.v17.i12.113305
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA AM3LB
UT WOS:001651521900017
PM 41479695
OA Green Accepted, gold
DA 2026-07-24
ER
PT J
AU de la Fuente, PZ
   Suescún, FC
   Larrán, RG
   Herrera, RS
   Fernández, GP
AF de la Fuente, Patricia Zorrilla
   Suescun, Federico Castillo
   Larran, Rodrigo Gonzalez
   Herrera, Ramon Sancibrian
   Fernandez, Galo Peralta
TI A novel dynamic abdominal wall traction system for open abdomen:
   preclinical evaluation
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Open abdomen (OA); Dynatract (R); Negative pressure wound therapy
   (NPWT); Temporary abdominal closure (TAC); Abdominal compartment
   syndrome (ACS); Abdominal closure techniques
ID PRESSURE WOUND THERAPY; CLOSURE TECHNIQUES; FASCIAL CLOSURE; MANAGEMENT
AB Aim: This study evaluates the efficacy and safety of Dynatract (R), a novel device designed to facilitate early primary closure and prevent aponeurotic retraction in patients with an open abdomen (OA). Method: A preclinical trial was conducted using a porcine model, comparing two groups: one treated solely with AbTheraTM Negative Pressure Wound Therapy (NPWT), and another combining AbTheraTM NPWT with Dynatract (R). The primary endpoint was to evaluate the distance between fascial edges, with secondary measures including the force required to achieve abdominal closure and overall closure success. Results: "The Dynatract (R) group showed a progressive reduction in fascial edge distance over time compared to the control group, with statistically significant differences observed at the caudal and midpoint positions (but not at the cranial position), as well as in the force required to achieve closure after 36 h. Complete fascial closure was achieved in all animals in both groups.
C1 [de la Fuente, Patricia Zorrilla; Suescun, Federico Castillo; Fernandez, Galo Peralta] Inst Invest Sanitaria Valdecilla IDIVAL, Avda Cardenal Herrera Oria S-N, Santander 39011, Spain.
   [de la Fuente, Patricia Zorrilla; Herrera, Ramon Sancibrian] Univ Cantabria, Avda Castros S-N, Santander 39005, Spain.
   [Suescun, Federico Castillo] Hosp Univ Marques Valdecilla, Avda Valdecilla S-N, Santander 39008, Spain.
C3 Hospital Universitario Marques de Valdecilla (HUMV); Universidad de
   Cantabria; Hospital Universitario Marques de Valdecilla (HUMV)
RP de la Fuente, PZ (通讯作者)，Inst Invest Sanitaria Valdecilla IDIVAL, Avda Cardenal Herrera Oria S-N, Santander 39011, Spain.
EM patricia.zorrilla@idival.org; fcastillo7@hotmail.com;
   rodrigoglarran@gmail.com; ramon.sancibrian@unican.es;
   galo.peralta@idival.org
RI ; Sancibrian, Ramon/J-8369-2016
OI Zorrilla, Patricia/0000-0002-8910-8469; Castillo Suescun,
   Federico/0000-0002-5092-8830; 
FU Instituto de Investigacio n Sanitaria Valdecilla (IDIVAL) [DTEC23/01]
FX Assistance with the study: none. This work has been made possible by a
   research grant (DTEC23/01) from Instituto de Investigacio n Sanitaria
   Valdecilla (IDIVAL) .
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JAN
PY 2026
VL 57
IS 1
AR 112849
DI 10.1016/j.injury.2025.112849
EA DEC 2025
PG 10
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA AM4DU
UT WOS:001651570600001
PM 41233200
OA Green Published, hybrid
DA 2026-07-24
ER
PT J
AU Wang, TT
   Jia, RF
   Zheng, XY
   Ma, CW
   Chen, X
   Cao, MC
   He, XY
   Wang, YF
AF Wang, TingTing
   Jia, RuFu
   Zheng, XinYing
   Ma, ChunWei
   Chen, Xi
   Cao, MingCong
   He, XiaoYang
   Wang, YaFei
TI Effect of Music Therapy Integrated with ORTCC Model-Based Nursing on
   Patients Undergoing Vacuum Sealing Drainage in Surgical Settings
SO NOISE & HEALTH
LA English
DT Article
DE music therapy; pain; quality of life; surgical wound
ID PRESSURE WOUND THERAPY
AB Objective: This study aimed to analyse the effects of music therapy combined with the Objective-Rules-Training-Check-Culture (ORTCC) model-based nursing in patients undergoing vacuum sealing drainage (VSD) for surgical wounds. Methods: In this retrospective cohort study, clinical data of 132 patients from Cangzhou Central Hospital receiving VSD for hand and foot surgeries between June 2022 and June 2023 were retrospectively analysed. In accordance with actual nursing protocols, participants were allocated to either the ORTCC group (n = 67), receiving systematic ORTCC model-based nursing, or the combination group (n = 65), receiving additional music therapy alongside ORTCC nursing. Outcomes included fear of disease progression [Fear of Progression Questionnaire-Short Form (FoP-Q-SF)], mood states [Brief Profile of Mood States (BPOMS)], quality of life [Generic Quality of Life Inventory-74 (GQOLI-74)], compliance rates, satisfaction scores and complication incidence. Results: No significant intergroup differences were observed in wound healing time, pain scores and complication rates (P > 0.05). Both groups exhibited reduced FoP-Q-SF and BPOMS scores after care compared with baseline, with significantly lower scores in the combination group than in the ORTCC group (P < 0.05). All GQOLI-74 domain scores increased after care in both groups, but they were significantly higher in the combination group (P < 0.05). The combination group demonstrated superior nursing compliance rates and satisfaction scores (P < 0.05). Conclusion: Surgical patients undergoing VSD and receiving combined music therapy and ORTCC model-based nursing exhibited significantly reduced fear of disease progression, mood improvement, enhanced quality of life and superior compliance and satisfaction, though no additional advantages were observed in physiological wound healing.
C1 [Wang, TingTing] Cangzhou Cent Hosp, Neuropsychol Dept Cognit Disorders, Cangzhou, Hebei, Peoples R China.
   [Wang, TingTing] Cangzhou Cent Hosp, Parkinsons Motor Disorders Dept, Cangzhou, Hebei, Peoples R China.
   [Jia, RuFu; Zheng, XinYing; Wang, YaFei] Cangzhou Cent Hosp, Nursing Dept, 16 Xinhua West Rd, Cangzhou 061001, Hebei, Peoples R China.
   [Ma, ChunWei] Yanshan Cty Peoples Hosp, Surg Dept, Cangzhou, Hebei, Peoples R China.
   [Chen, Xi] Cangzhou Cent Hosp, Orthoped Dept, Cangzhou, Hebei, Peoples R China.
   [Cao, MingCong] Cangzhou Cent Hosp, Ophthalmol Dept, Cangzhou, Hebei, Peoples R China.
   [He, XiaoYang] Cangzhou Cent Hosp, Surg Dept, Cangzhou, Hebei, Peoples R China.
RP Wang, YF (通讯作者)，Cangzhou Cent Hosp, Nursing Dept, 16 Xinhua West Rd, Cangzhou 061001, Hebei, Peoples R China.
EM dawsonhitler@163.com
RI /T-8558-2019; Ma, Chunwei/JWP-3755-2024
FU  [222106100]
FX Application of nursing intervention based on ORTCC model in
   perioperative patients undergoing surgical negative pressure closure and
   drainage (222106100).
CR Cai LY, 2022, INJURY, V53, P777, DOI 10.1016/j.injury.2021.10.018
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NR 22
TC 0
Z9 0
U1 1
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1463-1741
EI 1998-4030
J9 NOISE HEALTH
JI Noise Health
PD NOV-DEC
PY 2025
VL 27
IS 129
BP 879
EP 886
DI 10.4103/nah.nah_138_25
PG 8
WC Audiology & Speech-Language Pathology; Public, Environmental &
   Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Audiology & Speech-Language Pathology; Public, Environmental &
   Occupational Health
GA AO7NZ
UT WOS:001653155000003
PM 41482917
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Erten, EE
   Öztorun, CI
   Ertürk, A
   Demir, S
   Bostanci, SA
   Çayhan, VS
   Yildiz, M
   Akbas, I
   Emeksiz, S
   Özlü, SG
   Nur, M
   Senel, E
AF Erten, Elif Emel
   Oztorun, Can Ihsan
   Erturk, Ahmet
   Demir, Sabri
   Bostanci, Suleyman Arif
   Cayhan, Vildan Selin
   Yildiz, Muge
   Akbas, Irem
   Emeksiz, Serhat
   Ozlu, Sare Gulfem
   Nur, Mujdem
   Senel, Emrah
TI Evaluation of critical parameters for optimizing the therapeutic
   approach in pediatric patients with compartment syndrome during the 2023
   Türkiye earthquake disaster
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Compartment syndrome; pediatric trauma; earthquake; fasciotomy; crush
   injury; amputation; negative-pressure wound therapy (NPWT); hyperbaric
   oxygen therapy (HBOT); renal failure
ID ACUTE-RENAL-FAILURE; CRUSH SYNDROME; MARMARA EARTHQUAKE; INJURY;
   MORTALITY; VICTIMS
AB BACKGROUND: The 2023 T & uuml;rkiye earthquake resulted in a large number of pediatric victims with musculoskeletal trauma, many of whom developed compartment syndrome (CS) and crush-related complications. This study aimed to identify clinical and biochemical parameters associated with disease severity, renal failure, and limb loss in children affected by the disaster. METHODS: A retrospective analysis was conducted on 103 pediatric patients (0-18 years) admitted after the earthquake. Demo-graphic data, duration of entrapment, laboratory values (creatine kinase [CK], myoglobin, aspartate aminotransferase [AST], alanine aminotransferase [ALT], urea, potassium), and therapeutic interventions (fasciotomy, negative-pressure wound therapy [NPWT], hyperbaric oxygen therapy [HBOT], hemodialysis, and amputation) were evaluated. Receiver operating characteristic (ROC) analyses were used to determine cut-off values predicting adverse outcomes. RESULTS: Forty-seven patients (45.6%) developed compartment syndrome involving 68 limbs and underwent fasciotomy. Thirteen patients (12.6%) required limb amputation, and 19 (18.4%) underwent hemodialysis due to acute kidney injury. An entrapment dura-tion exceeding 8 hours (area under the curve [AUC]=0.84, p<0.001), CK>10,000 U/L, and myoglobin >4,000 ng/mL were independent predictors of renal failure, fasciotomy, and amputation. NPWT was applied in 66% and HBOT in 85% of patients with necrosis, con-tributing to an 82% limb salvage rate. No amputations occurred in patients without persistent necrosis. Three patients (2.9%) died from severe crush-related injuries and multi-organ failure. CONCLUSION: Prolonged entrapment and markedly elevated CK and myoglobin levels are reliable indicators of adverse outcomes in pediatric earthquake victims with compartment syndrome. Early recognition, timely decompression, and structured wound man-agement (NPWT and HBOT) are essential for improving survival and limb salvage when early surgical intervention is not feasible in large-scale disasters.
C1 [Erten, Elif Emel; Demir, Sabri; Cayhan, Vildan Selin; Yildiz, Muge; Akbas, Irem; Nur, Mujdem; Senel, Emrah] Univ Hlth Sci, Ankara Bilkent City Hosp, Dept Pediat Surg, Ankara, Turkiye.
   [Oztorun, Can Ihsan; Erturk, Ahmet; Bostanci, Suleyman Arif] Ankara Yildirim Beyazit Univ, Fac Med, Dept Pediat Surg, Ankara, Turkiye.
   [Emeksiz, Serhat] Ankara Yildirim Beyazit Univ, Fac Med, Dept Pediat Intens Care, Ankara, Turkiye.
   [Ozlu, Sare Gulfem] Ankara Yildirim Beyazit Univ, Fac Med, Dept Pediat Nephrol, Ankara, Turkiye.
C3 University of Health Sciences Turkey; Ankara Yildirim Beyazit
   University; Ankara Yildirim Beyazit University; Ankara Yildirim Beyazit
   University
RP Erten, EE (通讯作者)，Univ Hlth Sci, Ankara Bilkent City Hosp, Dept Pediat Surg, Ankara, Turkiye.
EM elifemelerten@hotmail.com
RI Emeksiz, Serhat/AAV-7613-2021; Demir, Sabri/Q-2538-2018; ÖZLÜ, Sare
   Gülfem/HCH-8357-2022; Bostancı, Süleyman/AAX-9009-2021; ertürk,
   ahmet/B-2369-2016; ÖZTORUN, can ihsan/AAF-1602-2019; barış akbaş,
   irem/HNP-6036-2023
CR Akbas E, 2024, INT ORTHOP, V48, P2513, DOI 10.1007/s00264-024-06280-8
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   World Health Organization, Turkiye and Syria earthquakes
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NR 28
TC 0
Z9 0
U1 2
U2 4
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, Turkiye
SN 1306-696X
EI 1307-7945
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD DEC
PY 2025
VL 31
IS 12
BP 1192
EP 1202
DI 10.14744/tjtes.2025.04808
PG 11
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA AP0BC
UT WOS:001653325800005
PM 41424420
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Neron, M
   Delmond, L
   Gourgou, S
   Delaine, S
   Chalbos, P
   Moussion, A
   Taoum, C
AF Neron, Mathias
   Delmond, Laure
   Gourgou, Sophie
   Delaine, Stephanie
   Chalbos, Patrick
   Moussion, Aurore
   Taoum, Christophe
TI Prevention of postoperative complications with negative pressure wound
   therapy after complex breast cancer surgery: a study protocol of a
   randomised controlled trial (TPN-SEIN)
SO BMJ OPEN
LA English
DT Article
DE ONCOLOGY; Breast surgery; WOUND MANAGEMENT; Clinical Protocols
ID SURGICAL OUTCOMES; MASTECTOMY; RECONSTRUCTION; TRENDS; CHEMOTHERAPY;
   IMPACT; LIFE
AB Background Complex breast surgery, including immediate breast reconstruction and oncoplastic procedures, is increasingly performed to optimise oncologic and aesthetic outcomes. Postoperative wound healing complications remain a major concern, particularly in high-risk patients. Negative pressure wound therapy (NPWT) has been shown to improve wound healing in various surgical fields. However, its effectiveness in oncologic breast surgery remains insufficiently studied. This study aims to evaluate the efficacy of NPWT in reducing wound healing complications in complex breast cancer surgery.Methods The TPN-SEIN study is a prospective, randomised, controlled, open-label, multicentre, phase III clinical trial. A total of 254 patients undergoing complex breast cancer surgery will be randomised either to arm 1 (NPWT immediately postoperatively for 7 days) or arm 2 (standard wound care). The primary endpoint is the rate of wound healing complications at day 30, defined as at least one of the following: deep postoperative infection of the prosthetic pocket, wound dehiscence or incomplete healing. Secondary endpoints include surgical site infection at day 90, reoperation rate, hospital readmission rate, time to complete healing, time to adjuvant treatment initiation, quality of life (European Organisation for Research and Treatment of Cancer Core Quality of Life questionnaire and breast cancer-specific quality of life questionnaire (QLQ-C30)), patient satisfaction and medico-economic outcomes.Ethics and dissemination The study was approved by the French national ethics committee (Comit & eacute; de Protection des Personnes Est II, 5 December 2024, reference 24.04416.000295) and the institutional review board (IRB-COMERE, reference ICM-RCM 2024/11). The French National Agency for the Safety of Health Products has been notified. The study results will be presented at both national and international conferences and will also be published in a peer-reviewed journal.Trial registration number NCT06265558.
C1 [Neron, Mathias; Delmond, Laure; Taoum, Christophe] Montpellier Canc Inst, Dept Surg Oncol, Montpellier, France.
   [Neron, Mathias] Montpellier Canc Res Inst, INSERM, U1194, Montpellier, France.
   [Neron, Mathias; Delmond, Laure; Gourgou, Sophie; Delaine, Stephanie; Chalbos, Patrick; Moussion, Aurore; Taoum, Christophe] Univ Montpellier, Montpellier, France.
   [Gourgou, Sophie] Montpellier Canc Inst, Biometr Unit, Montpellier, France.
   [Delaine, Stephanie; Chalbos, Patrick; Moussion, Aurore] Montpellier Canc Inst, Clin Res & Innovat Dept, Montpellier, France.
C3 Universite de Montpellier; UNICANCER; Universite de Montpellier;
   Institut Regional du Cancer Montpellier / Val d'Aurelle (ICM); Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; Universite de Montpellier; Universite de Montpellier
RP Taoum, C (通讯作者)，Montpellier Canc Inst, Dept Surg Oncol, Montpellier, France.; Taoum, C (通讯作者)，Univ Montpellier, Montpellier, France.
EM Mathias.Neron@icm.unicancer.fr; Laure.Delmond@icm.unicancer.fr;
   Sophie.Gourgou@icm.unicancer.fr; Stephanie.Delaine@icm.unicancer.fr;
   Patrick.Chalbos@icm.unicancer.fr; Aurore.Moussion@icm.unicancer.fr;
   christophe.taoum@icm.unicancer.fr
OI TAOUM, Christophe/0000-0002-7401-331X
FU French Ministry of Health's Directorate General for Healthcare Provision
   [PHRCi-2022-87]
FX This research was funded by the French Ministry of Health's Directorate
   General for Healthcare Provision (DGOS) through the 2022 Interregional
   Hospital Clinical Research Program (PHRCi 2022), under grant number
   PHRCi-2022-87.
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   Rousset-Jablonski C, 2024, BREAST CANCER-TOKYO, V31, P633, DOI 10.1007/s12282-024-01576-4
   Saunders C, 2021, BJS OPEN, V5, DOI 10.1093/bjsopen/zraa003
   Tanaydin V, 2018, AESTHET PLAST SURG, V42, P927, DOI 10.1007/s00266-018-1095-0
   Wilkins EG, 2018, ANN SURG, V267, P164, DOI 10.1097/SLA.0000000000002033
   Witmer TJK, 2022, J PLAST RECONSTR AES, V75, P2569, DOI 10.1016/j.bjps.2022.02.050
   Woo SH, 2023, J PLAST SURG HAND SU, V57, P370, DOI 10.1080/2000656X.2022.2118757
NR 35
TC 0
Z9 1
U1 4
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JAN 2
PY 2026
VL 16
IS 1
AR e103827
DI 10.1136/bmjopen-2025-103827
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AP6CQ
UT WOS:001653737800001
PM 41485781
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Cho, HS
   Kim, MS
   Lee, C
   Ahn, HY
AF Cho, Ho Seong
   Kim, Min Su
   Lee, Chiseung
   Ahn, Hyo Yeong
TI Modified Negative Pressure Wound Therapy Using Surgical Drain and
   Occlusive Sutures for Leakage After Esophageal Injury
SO INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE esophageal injury; negative pressure wound therapy; anastomotic leakage
ID MANAGEMENT
AB Oesophageal leakage is a serious complication that can lead to infection, sepsis, malnutrition, and death. Negative Pressure Wound Therapy has been increasingly used to treat oesophageal leaks; however, in cases of cervical oesophageal leakage, deep tract and anatomical complexity often hinder an airtight seal and limit transmission of negative pressure. We developed a modified Negative Pressure Wound Therapy technique by connecting a surgical drain to the base of the foam dressing and securing it with subcutaneous occlusive sutures to ensure a reliable seal and effective negative pressure transmission. Four cases of modified application were included in this study. All leaks were controlled without complications attributable to the procedure. The modified Negative Pressure Wound Therapy technique effectively addresses the limitations of conventional methods in complex anatomical regions. By ensuring a reliable occlusive seal and enhancing negative pressure transmission, this approach promotes optimal wound healing through improved exudate clearance and reduced maceration.
   Oesophageal leakage has multiple etiologies, especially due to anastomotic leakage or oesophageal injury.
C1 [Cho, Ho Seong; Ahn, Hyo Yeong] Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Dept Thorac & Cardiovasc Surg, Pusan 49241, South Korea.
   [Cho, Ho Seong; Lee, Chiseung; Ahn, Hyo Yeong] Pusan Natl Univ Hosp, Biomed Res Inst, Pusan 49241, South Korea.
   [Kim, Min Su] Pusan Natl Univ, Grad Sch, Dept Biomed Engn, Busan 49241, South Korea.
   [Lee, Chiseung] Pusan Natl Univ, Sch Med, Dept Biomed Engn, Pusan 49241, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital; Pusan National
   University; Pusan National University
RP Ahn, HY (通讯作者)，Pusan Natl Univ, Pusan Natl Univ Hosp, Med Res Inst, Coll Med,Dept Thorac & Cardiovasc Surg, 179 Gudeok Ro, Busan 49241, South Korea.
EM doctorahn02@hanmail.net
OI Ahn, Hyo Yeong/0000-0003-3198-8237; Cho, Ho Seong/0000-0002-9512-8909
FU National Research Foundation of Korea (NRF) [RS-2023-00252649]
FX None declared.
CR Evans RPT, 2020, DIS ESOPHAGUS, V33, DOI 10.1093/dote/doz007
   Housman B, 2021, J SURG ONCOL, V124, P529, DOI 10.1002/jso.26550
   Livingstone I, 2021, CLIN ENDOSC, V54, P787
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   Rispoli DM, 2010, J TRAUMA, V68, P1247, DOI 10.1097/TA.0b013e3181d3cc3c
NR 7
TC 0
Z9 0
U1 1
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2753-670X
J9 INTERDISC CARDIOV TH
JI Interdiscip. Cardiovasc. Thorac. Surg.
PD JAN
PY 2026
VL 41
IS 1
AR ivaf296
DI 10.1093/icvts/ivaf296
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AR1RQ
UT WOS:001654794000001
PM 41346261
OA gold
DA 2026-07-24
ER
PT J
AU Kudou, M
   Morino, Y
   Matsuda, T
   Tarumto, K
   Yamazato, Y
   Hikami, S
   Tanaka, R
   Fukuda, K
   Yamamoto, Y
   Shimizu, Y
   Shiozaki, A
AF Kudou, Michihiro
   Morino, Yoshiki
   Matsuda, Tomoya
   Tarumto, Koji
   Yamazato, Yuzo
   Hikami, Shoichiro
   Tanaka, Ryoichi
   Fukuda, Kenichiro
   Yamamoto, Yoshiki
   Shimizu, Yoshihiro
   Shiozaki, Atsushi
TI Combined prophylactic negative-pressure wound therapy and preoperative
   oral antibiotics reduce perineal wound complications after
   abdominoperineal resection
SO SURGERY TODAY
LA English
DT Article
DE Rectal cancer; Abdominoperineal resection; Surgical site infection;
   Negative pressure wound therapy; Antibiotics
ID SURGICAL SITE INFECTION; CANCER SURGERY; POSTOPERATIVE COMPLICATIONS;
   PREVENTION; SURVIVAL; CLOSURE; IMPACT; COLON
AB Purpose Perineal wound complications after abdominoperineal resection (APR) remain a major concern, often leading to poor patient outcomes. Prophylactic negative-pressure wound therapy (pNPWT) and oral antibiotics (OA) administration have individually shown promise in reducing surgical site infections (SSIs). The present study investigated their combined effect for the prevention of perineal wound complications after APR. Methods This retrospective study included patients who underwent APR for lower rectal cancer between April 2016 and March 2025. Patients were divided into two groups: conventional treatment (CT) and those receiving a combination of pNPWT and preoperative OA (pNPWT + OA). Postoperative complications were compared. Results Sixteen patients were included in the pNPWT + OA group and 14 in the CT group. The incidence of superficial peri-neal SSIs was significantly lower in the pNPWT + OA group than in the CT group (6.3% vs. 42.9%, p = 0.030), with no cases of wound dehiscence (0% vs. 28.6%, p = 0.036). Furthermore, preoperative albumin < 3.0 g/dL correlated with the incidence of perineal SSIs and wound dehiscence. Conclusion The combined use of pNPWT and OA was associated with a reduction in perineal wound infections and dehis-cence following APR. This approach may improve postoperative outcomes; however, these findings are hypothesis-generat-ing and should be validated in large-scale, prospective studies, including cost-effectiveness analyses.
C1 [Kudou, Michihiro; Morino, Yoshiki; Yamazato, Yuzo; Hikami, Shoichiro; Fukuda, Kenichiro; Yamamoto, Yoshiki; Shimizu, Yoshihiro] Kyoto Okamoto Mem Hosp, Dept Digest Surg, Kyoto, Japan.
   [Kudou, Michihiro; Shiozaki, Atsushi] Kyoto Prefectural Univ Med, Dept Surg, Div Digest Surg, Kyoto, Japan.
   [Matsuda, Tomoya; Tarumto, Koji; Tanaka, Ryoichi] Kyoto Okamoto Mem Hosp, Dept Surg, Kyoto, Japan.
C3 Kyoto Prefectural University of Medicine
RP Kudou, M (通讯作者)，Kyoto Okamoto Mem Hosp, Dept Digest Surg, Kyoto, Japan.; Kudou, M (通讯作者)，Kyoto Prefectural Univ Med, Dept Surg, Div Digest Surg, Kyoto, Japan.
EM posit@koto.kpu-m.ac.jp
CR Aoyama T, 2017, CANCER MED-US, V6, P1573, DOI 10.1002/cam4.1126
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   Strugala V, 2017, SURG INFECT, V18, P810, DOI 10.1089/sur.2017.156
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD JUL
PY 2026
VL 56
IS 7
BP 1184
EP 1190
DI 10.1007/s00595-025-03226-4
EA JAN 2026
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KE8WX
UT WOS:001654947400001
PM 41495560
DA 2026-07-24
ER
PT J
AU Alnemri, A
   Moroco, A
   Garg, N
   Bridgham, K
   Davis, M
   Kaki, P
   McCann, A
   Thal, A
   Krein, H
   Heffelfinger, R
AF Alnemri, Angela
   Moroco, Annie
   Garg, Neha
   Bridgham, Kelly
   Davis, Matt
   Kaki, Praneet
   McCann, Adam
   Thal, Arielle
   Krein, Howard
   Heffelfinger, Ryan
TI Timing of Split Thickness Skin Grafting for Radial Forearm Free Flaps on
   Donor Site Morbidity
SO MICROSURGERY
LA English
DT Article
DE dermal regeneration matrix; donor site morbidity; free flap
   reconstruction
ID INTEGRA ARTIFICIAL DERMIS; CLINICAL-TRIAL; RECONSTRUCTION; FULL;
   CLOSURE; HEAD
AB Introduction The radial forearm free flap (RFFF) is a versatile free flap in the reconstruction of head and neck defects. There is little consensus on the optimal technique for reconstructing RFFF donor site defects. Our group previously reported early results using staged reconstruction with initial placement of Integra, a dermal regeneration matrix, followed by a split thickness skin graft (STSG), resulting in excellent aesthetic and functional outcomes. Here we provide our long-term experience using staged STSG compared to primary STSG for the reconstruction of RFFF donor site defects.Methods Patients undergoing RFFF reconstruction of head and neck defects at a single institution between May 2012 and April 2023 were retrospectively reviewed. Primary versus staged STSG placement was compared in terms of donor site morbidity.Results A total of 179 patients were included: 46 (25.7%) primary STSG and 133 (73.3%) staged STSG. Following primary STSG, 34 (73.9%) patients had a vacuum-assisted closure (VAC) and 12 (26.1%) had an iodine-coated petroleum gauze bolster placed. In the staged STSG group, all patients had a VAC after Integra placement. After the second stage, 30 (22.6%) patients had a VAC, and 103 (77.4%) patients had a bolster placed. Compared to the staged group, the primary group had a significantly higher rate of skin graft breakdown (21.7% vs. 6.0%; p = 0.008) and tendon exposure (19.6% vs. 3.8%; p = 0.002). In the staged group, bolster placement was associated with a lower rate of skin graft breakdown compared to VAC (2.9% vs. 16.7%; p = 0.015).Conclusion When reconstructing donor site defects following RFFFs, staged reconstruction with initial placement of Integra followed by STSG and bolster placement may result in lower rates of skin graft breakdown and tendon exposure.
C1 [Alnemri, Angela; Moroco, Annie; Garg, Neha; Bridgham, Kelly; McCann, Adam; Thal, Arielle; Krein, Howard; Heffelfinger, Ryan] Thomas Jefferson Univ Hosp, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19107 USA.
   [Davis, Matt; Kaki, Praneet] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA USA.
C3 Thomas Jefferson University; Thomas Jefferson University
RP Alnemri, A (通讯作者)，Thomas Jefferson Univ Hosp, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19107 USA.
EM angela.alnemri2@jefferson.edu
RI Heffelfinger, Ryan/PWF-5484-2026; THAL, Arielle/IQV-1528-2023
OI THAL, Arielle/0000-0002-7498-8512; Bridgham, Kelly/0000-0001-7043-0602
CR Abbate V, 2021, J CRANIOFAC SURG, V32, pE205, DOI 10.1097/SCS.0000000000006808
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   Al-Aroomi MA, 2024, PLAST RECONSTR SURG, V154, P650, DOI 10.1097/PRS.0000000000011022
   Archibald H, 2023, SEMIN PLAST SURG, V37, P26, DOI 10.1055/s-0042-1759795
   Bernstein JL, 2020, J CRANIOFAC SURG, V31, pE511, DOI 10.1097/SCS.0000000000006646
   Bruin LL, 2023, J RECONSTR MICROSURG, V39, P320, DOI 10.1055/a-1939-5987
   BURKE JF, 1981, ANN SURG, V194, P413, DOI 10.1097/00000658-198110000-00005
   Cao XL, 2022, PLAST RECONSTR SURG, V150, P1341, DOI 10.1097/PRS.0000000000009704
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   Davis WJ, 2011, J HAND MICROSURG, V3, P18, DOI 10.1007/s12593-011-0036-9
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NR 37
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD JAN 7
PY 2026
VL 46
IS 1
AR e70174
DI 10.1002/micr.70174
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AS3UK
UT WOS:001655620700001
PM 41499483
OA Bronze
DA 2026-07-24
ER
PT J
AU Foley, MP
   Fahey, C
   Byrne, AM
   Leahy, R
   Dempsey, L
   Westby, D
   Walsh, SR
AF Power Foley, Megan
   Fahey, Ciara
   Byrne, Anne-Marie
   Leahy, Roisin
   Dempsey, Laura
   Westby, Daniel
   Walsh, Stewart R.
TI Prophylactic Incisional Negative Pressure wound therapy (NPWT) for major
   Amputations (PINTA): protocol for randomized controlled trial of
   single-use NPWT devices for closed-incision major lower extremity
   amputations
SO BJS OPEN
LA English
DT Article
DE surgical complications; peripheral arterial disease; diabetes mellitus;
   medical device
ID SURGICAL-SITE INFECTIONS; LOWER-LIMB AMPUTATION; RISK-FACTORS;
   COMPLICATIONS; PREVALENCE; MORTALITY
AB Background Major lower extremity amputations are frequently performed for end-stage peripheral arterial disease and progressive diabetic foot complications. Wound complications after amputation affect up to one-third of limbs. The patient cohort undergoing amputation are typically high risk for poor wound healing, often with unmodifiable risk factors in an urgent clinical setting. Incisional negative pressure wound therapy (NPWT) has been shown to reduce wound complications in other high-risk populations. This randomized controlled trial investigates whether prophylactic NPWT reduces wound complications in patients after major amputation compared with standard dry dressings.Methods This protocol describes a prospective, multicentre, randomized controlled trial with an internal pilot recruiting patients undergoing major lower extremity amputation for any indication. Limbs will be randomized to receive either a single-use NPWT device on their closed surgical incision or a dry dressing. The primary clinical outcome is the rate of wound complications. Secondary outcomes include reoperation rates, length of hospital stay, cost-effectiveness of NPWT, and patient-reported quality of life. Follow-up will continue to 6 months after surgery. The initial pilot phase has a recruitment target of 96 limbs, whereas an estimated 728 patients will be required to power a definitive trial adequately.Discussion This trial aims to supplement the existing poor-quality data on this important aspect of care and equip healthcare professionals to make cost-effective decisions regarding postoperative wound management.
   Protocol for a pragmatic randomized controlled trial comparing prophylactic negative pressure wound therapy devices with standard care for closed-incision major lower extremity amputations. Outcomes include composite wound complications at 30 days, patient-reported outcomes on quality of life and wound-related quality of life, and cost-effectiveness. Adequately powered to 90% with a target sample size of 728 patients.
C1 [Power Foley, Megan; Westby, Daniel; Walsh, Stewart R.] Univ Hosp Galway, Dept Vasc Surg, Newcastle Rd, Galway H91 YR71, Ireland.
   [Power Foley, Megan] Irish Surg Res Collaborat, Dublin, Ireland.
   [Fahey, Ciara; Byrne, Anne-Marie; Leahy, Roisin; Dempsey, Laura; Walsh, Stewart R.] Royal Coll Surgeons Ireland, Natl Surg Res Support Ctr, Dublin, Ireland.
   [Walsh, Stewart R.] Univ Galway, Lambe Inst Translat Res, Galway, Ireland.
C3 Royal College of Surgeons in Ireland - RCSI; Ollscoil na
   Gaillimhe-University of Galway
RP Foley, MP (通讯作者)，Univ Hosp Galway, Dept Vasc Surg, Newcastle Rd, Galway H91 YR71, Ireland.
EM meganpfoley@rcsi.com
RI Walsh, Stewart/AFZ-2791-2022
OI Walsh, Stewart/0000-0002-1006-9541; Power Foley,
   Megan/0000-0002-7731-3182
FU National Surgical Research Support Centre; Royal College of Surgeons in
   Ireland
FX Trial funding provided by National Surgical Research Support Centre at
   Royal College of Surgeons in Ireland. No funding was received by
   industry.
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NR 28
TC 0
Z9 0
U1 5
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD FEB
PY 2026
VL 10
IS 1
AR zraf159
DI 10.1093/bjsopen/zraf159
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AT2QI
UT WOS:001656224400001
PM 41504704
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sánchez-De-Toca, SE
   Moreno, FM
   Sánchez, PU
   Jiménez, FM
   Massaoui, YA
   García, LC
   Betrán, PB
   Marsellá, AJL
   Ledesma, MM
   Tabanera, AV
   Alonso, MD
   Calvo, AG
AF Sanchez-De-Toca, Sofia E.
   Moreno, Fernando Mendoza
   Sanchez, Patricia Urbon
   Jimenez, Felix Manes
   Massaoui, Yousef Allaoua
   Garcia, Lucas Casalduero
   Betran, Pablo Barat
   Lopez Marsella, Alejandra Julia
   Ledesma, Maria Mejias
   Tabanera, Alberto Vilar
   Alonso, Manuel Diez
   Calvo, Alberto Gutierrez
TI Curative surgery enabled by radiotherapy in rectal cancer: A case report
SO ONCOLOGY LETTERS
LA English
DT Article
DE rectal cancer; radiotherapy; 3D reconstruction; pelvic exenteration;
   perineal reconstruction
AB Neoadjuvant chemo-radiotherapy is the standard of care for patients with locally advanced rectal cancer. However, certain patients are ineligible for chemotherapy due to clinical contraindications such as active infections. Although neoadjuvant therapy remains the preferred approach, guidelines are limited for patients who cannot receive combined treatment. The present report describes a case in which radiotherapy alone, initiated with palliative intent, enabled complete surgical resection. A 46-year-old male patient presented with fever and proctalgia. Imaging revealed a large rectal mass associated with an ischiorectal abscess. Biopsy confirmed T4bN1 rectal adenocarcinoma. Chemotherapy was contraindicated due to ongoing infection; therefore, a diverting colostomy was performed. Short-course radiotherapy led to marked tumor regression. Subsequent pelvic exenteration achieved complete tumor removal. Postoperative wound dehiscence was managed successfully with vacuum-assisted closure therapy. No recurrence was observed on follow-up. The current case illustrates that radiotherapy alone may serve as a bridge to curative surgery in patients unfit for chemo-radiotherapy. The use of 3D reconstruction markedly improved preoperative planning and facilitated precise surgical resection. Additionally, perineal closure with Vicryl mesh and omental interposition minimized postoperative complications. In conclusion, in selected patients with contraindications to total neoadjuvant therapy, radiotherapy alone may be a feasible alternative to enable radical resection. Advanced surgical planning with 3D modeling can enhance outcomes in complex pelvic surgery.
C1 [Sanchez-De-Toca, Sofia E.; Moreno, Fernando Mendoza; Sanchez, Patricia Urbon; Jimenez, Felix Manes; Massaoui, Yousef Allaoua; Garcia, Lucas Casalduero; Betran, Pablo Barat; Lopez Marsella, Alejandra Julia; Ledesma, Maria Mejias; Tabanera, Alberto Vilar; Alonso, Manuel Diez; Calvo, Alberto Gutierrez] Principe Asturias Teaching Hosp, Dept Gen & Digest Surg, Carretera Alcala Meco 1, Madrid 28805, Spain.
RP Sánchez-De-Toca, SE (通讯作者)，Principe Asturias Teaching Hosp, Dept Gen & Digest Surg, Carretera Alcala Meco 1, Madrid 28805, Spain.
EM sofia.sanchezdetoca@hotmail.com
CR Ansari N, 2017, ANN SURG, V265, P882, DOI 10.1097/SLA.0000000000001987
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NR 20
TC 0
Z9 0
U1 1
U2 1
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-1074
EI 1792-1082
J9 ONCOL LETT
JI Oncol. Lett.
PD FEB
PY 2026
VL 31
IS 2
AR 92
DI 10.3892/ol.2025.15445
PG 5
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AX1NN
UT WOS:001658863000001
PM 41522807
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gonzalez, TD
   Ribaric, I
   Gomes, YM
   André, MM
   Zua, FQD
   Gonçalves, MAD
   Ivo, M
   Leonhardt, MD
   Silva, JD
   Kojima, KE
AF Gonzalez, Theodoro Da Cunha
   Ribaric, Ivan
   Gomes, Yuri Macari
   Andre, Mbilu Miguel
   Zua, Fernando Quissolo Dalaia
   Goncalves, Maria Adelaide De Miranda
   Ivo, Mauricio
   Leonhardt, Marcos De Camargo
   Silva, Jorge Dos Santos
   Kojima, Kodi Edson
TI RETROSPECTIVE ANALYSIS OF THE IMPACT OF NEGATIVE PRESSURE WOUND THERAPY
   ON COMPLICATIONS OF DELAYED COVERAGE OF IIIB EXPOSED TIBIAL FRACTURES
SO ACTA ORTOPEDICA BRASILEIRA
LA English
DT Article
DE Negative-Pressure Wound Therapy; Fractures, Ununited; Amputation
ID RISK-FACTORS; MANAGEMENT; INFECTION; NONUNION; OUTCOMES
AB Objective: To evaluate whether NPWT in delayed coverage of Gustilo-Anderson Type IIIB open tibial fractures reduces the complication rate, including deep infection, nonunion, and amputation. Methods: Retrospective case series including patients with Gustilo-Anderson Type IIIB open tibial shaft fractures treated between January 2014 and December 2017 with NPWT. The outcome measures were incidence of deep infection, nonunion, and amputation. Analysis of time to coverage (within 7 days vs. after 7 days) and type of soft tissue coverage. Results: 26 patients with open tibial shaft fractures, predominantly male (96.2%), mean age 33.4 +/- 13.9 years. Seven patients (26.9%) received coverage within 7 days; 19 patients (73.1%) received delayed coverage. The flap types were Myocutaneous (42.3%), microsurgical (34.6%), fasciocutaneous (23.1%). The overall infection rate was 50%, no significant difference between early (57.1%) and delayed (47.4%) coverage groups (p > 0.999). No amputations in the early coverage group; 2 (10.5%) in the delayed coverage group. Nonunion rates were 42.9% (early) and 36.8% (delayed). Overall complication rate: 85.7% (early) vs. 57.9% (delayed) (p = 0.357). Conclusion: NPWT may exert a protective effect in cases of delayed coverage by isolating the wound and promoting healing. Level of Evidence III; Retrospectivef study.
C1 [Gonzalez, Theodoro Da Cunha; Ribaric, Ivan; Gomes, Yuri Macari; Andre, Mbilu Miguel; Zua, Fernando Quissolo Dalaia; Goncalves, Maria Adelaide De Miranda; Ivo, Mauricio; Leonhardt, Marcos De Camargo; Silva, Jorge Dos Santos; Kojima, Kodi Edson] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Grp Trauma,Inst Ortoped & Traumatol, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo
RP Kojima, KE (通讯作者)，333 Rua Dr Ovidio Pires Campos, BR-05402000 Sao Paulo, SP, Brazil.
EM kodi.kojima@hc.fm.usp.br
RI Santos Silva, Jorge dos Santos Silva/GMW-8109-2022; Kojima,
   Kodi/ACN-8737-2022
OI Ane, Mbilu Miguel/0009-0009-1260-0672; Macari Gomes,
   Yuri/0009-0002-1184-7867
CR Al-Hourani K, 2021, INJURY, V52, P378, DOI 10.1016/j.injury.2021.01.021
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU ATHA COMUNICACAO & EDITORA
PI SAO PAULO
PA RUA MACHADO BITTENCOURT, 190-40 ANDAR, CONJ 410, SAO PAULO, Sao Paulo,
   BRAZIL
SN 1413-7852
EI 1809-4406
J9 ACTA ORTOP BRAS
JI Acta Ortop. Bras.
PY 2025
VL 33
SI SI
AR e290249
DI 10.1590/1413-785220253303e290249
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA AX4SU
UT WOS:001659081200005
PM 41393529
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ch'ng, JK
   Yap, CJQ
   Mo, MJ
   Chew, KY
   Png, W
   Feng, JJ
AF Ch'ng, Jack Kian
   Yap, Charyl Jia Qi
   Mo, Michelle Jiaqi
   Chew, Khong Yik
   Png, Wenxian
   Feng, Jiajun
TI Diabetic Ray Amputation Wounds Managed With Local Flap Surgery and
   Negative Pressure Wound Therapy: A Case Series
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE amputation; case series; diabetic; foot ulcer; negative-pressure wound
   therapy; surgical
ID FOOT ULCERS
AB A new surgical technique for ray amputation of the diabetic foot is described. The procedure provides soft tissue reconstruction using a local flap in combination with negative pressure wound therapy to close these wounds safely and effectively. This article reports on 12 patients treated with this technique in a Tertiary Hospital/General Hospital in Singapore and compares their outcomes to those of 12 comparative cases from neighbouring institutions under the same health group who received conventional dressings. The new technique led to a higher number of healed wounds (12 vs. 4) and a shorter median time to healing (46.5 vs. 196.5 days). No major amputation or further minor amputation of the target limb occurred in the group treated with the new technique, whereas one major amputation and two further minor amputations took place in the comparison group. Our results suggest that the new technique is promising in this diabetic population with concurrent comorbidities.
C1 [Ch'ng, Jack Kian] Sengkang Gen Hosp, Vasc Surg Serv, Singapore, Singapore.
   [Ch'ng, Jack Kian; Yap, Charyl Jia Qi] Singapore Gen Hosp, Dept Vasc Surg, Singapore, Singapore.
   [Mo, Michelle Jiaqi] Sengkang Gen Hosp, Dept Populat Hlth & Integrated Care, Singapore, Singapore.
   [Chew, Khong Yik; Feng, Jiajun] Sengkang Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore, Singapore.
   [Png, Wenxian] Sengkang Gen Hosp, Dept Orthopaed Surg, Singapore, Singapore.
C3 Singapore General Hospital
RP Feng, JJ (通讯作者)，Sengkang Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore, Singapore.
EM fengjj@gmail.com
RI ; FENG, Jiajun/JFJ-1528-2023
OI Yap, Charyl Jia Qi/0000-0002-8606-0842; Feng,
   Jiajun/0000-0002-6988-4145; Mo, Michelle/0009-0006-6130-5440; 
CR Armstrong David G, 2007, Int Wound J, V4, P79, DOI 10.1111/j.1742-481X.2006.00270.x
   Armstrong DG, 2023, JAMA-J AM MED ASSOC, V330, P62, DOI 10.1001/jama.2023.10578
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NR 30
TC 0
Z9 1
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JAN 11
PY 2026
VL 23
IS 1
AR e70819
DI 10.1111/iwj.70819
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AX6EN
UT WOS:001659179300001
PM 41520662
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhao, BP
   Luo, SW
   He, JL
   Yang, L
   Zou, Q
   Zhang, M
   Wang, BY
   Yu, HH
   Guo, H
   Ye, C
AF Zhao, Baoping
   Luo, Siwei
   He, Jialin
   Yang, Long
   Zou, Qiang
   Zhang, Meng
   Wang, Benyan
   Yu, Huihui
   Guo, Hao
   Ye, Chuan
TI Original Clinical efficacy of mechanically activated tissue retractor
   combined with vacuum sealing drainage for treating deep soft tissue
   defects: a prospective study
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Tissue retractor; vacuum sealing drainage; reconstruction; soft tissue;
   prospective
ID DONOR-SITE MORBIDITY; SKIN; RECONSTRUCTION
AB Objective: This study aimed to compare the clinical efficacy of mechanically activated tissue retractor (MATR) combined with vacuum sealing drainage (VSD) versus conventional VSD for treating deep soft tissue defects. Methods: This prospective study included 53 patients with deep soft tissue defects treated between July 2024 and April 2025. The combination group (26 patients) received MATR combined with VSD, while the control group (27 patients) received conventional VSD. Outcome measures included defect healing time, rate of defect Daily Living Scale, ADLS), scarring (Vancouver Scar Scale, VSS), and perioperative complications. Chi-square test, t-test, and ANOVA were used to compare differences. Results: The combination group demonstrated a significantly shorter defect healing time and lower perioperative complication rate than the control group (all P < 0.05). At 14 days and 21 days after surgery, the combination group demonstrated superior defect healing, mature granulation, and skin survival status compared to the control group (all P < 0.05). Additionally, the combination group had significantly lower VAS scores and higher ADLS scores than the control group (all P < 0.05). At 3 months after defect healing, the combination group again showed significantly lower VAS and VSS scores, and higher ADLS scores than the control group (all P < 0.05). Conclusion: MATR combined with VSD was more effective in treating deep soft tissue defects compared to conventional VSD.
C1 [Zhao, Baoping; Zhang, Meng; Wang, Benyan; Yu, Huihui; Guo, Hao] Guizhou Med Univ, Affiliated Xinyi Hosp, Dept Trauma Orthoped, Xinyi 562400, Guizhou, Peoples R China.
   [Luo, Siwei; Yang, Long; Zou, Qiang; Ye, Chuan] Guizhou Med Univ, Dept Orthoped, Affiliated Hosp, Guiyang 550004, Guizhou, Peoples R China.
   [He, Jialin] Zunyi Med Univ, Affiliated Hosp, Dept Spine Surg, Zunyi 563000, Guizhou, Peoples R China.
C3 Guizhou Medical University; Guizhou Medical University; Zunyi Medical
   University
RP Ye, C (通讯作者)，Guizhou Med Univ, Dept Orthoped, Affiliated Hosp, Guiyang 550004, Guizhou, Peoples R China.
EM yechuanchina@hotmail.com
RI yu, huihui/JQJ-5722-2023
FU Guizhou Provincial Science and Technology Program Project [LC2025036];
   The 2025 Qianxinan Prefecture Medical Research Collaborative Project
   [2025-10]
FX We extend our gratitude to medical staff of Xingyi People's Hospital for
   their support and assistance. We also thank all the participants in this
   study. This study was supported by Guizhou Provincial Science and
   Technology Program Project (No. LC2025036) and 2025 Qianxinan Prefecture
   Medical Research Collaborative Project (No. 2025-10) .
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   Yin JY, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.1028410
   Yin Z, 2025, LASER MED SCI, V40, DOI [10.1007/s10103-025-04333-x, 10.1007/s10103-025-04333-x]
   Yu MW, 2023, CLIN COSMET INV DERM, V16, P793, DOI 10.2147/CCID.S397618
   Zhang YL, 2023, BMC MUSCULOSKEL DIS, V24, DOI 10.1186/s12891-023-06475-x
   Zhang YF, 2024, INJURY, V55, DOI 10.1016/j.injury.2024.111755
   Zhao WY, 2020, WOUND REPAIR REGEN, V28, P326, DOI 10.1111/wrr.12789
NR 32
TC 0
Z9 0
U1 1
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2025
VL 17
IS 12
BP 9894
EP 9904
DI 10.62347/TORU2999
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA AY1UR
UT WOS:001659561700010
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Ohashi, W
   Yoneda, K
   Kanda, D
   Ueda, K
   Ito, H
   Takegawa, R
   Hirose, T
   Sakai, T
   Oda, J
AF Ohashi, Wakako
   Yoneda, Kazuhiro
   Kanda, Daisuke
   Ueda, Kenichi
   Ito, Hiroshi
   Takegawa, Ryosuke
   Hirose, Tomoya
   Sakai, Tomohiko
   Oda, Jun
TI Wound Management Strategy for Burn Injuries During Pelvic External
   Fixation: A Case Report on the Practical Use of Negative Pressure Wound
   Therapy
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
DE burn injury; pelvic fracture; external fixation; negative pressure wound
   therapy; stoma paste sealing technique; silver-containing dressing
AB Burn management in patients requiring pelvic external fixation is extremely challenging due to restricted positioning and difficulty maintaining airtight negative pressure wound therapy (NPWT). Practical techniques to secure NPWT in this setting are rarely described. A 53-year-old man sustained 26% TBSA deep burns and an unstable pelvic fracture treated with external fixation. Circumferential trunk eschar excision was achieved by alternating lateral positions, as prone positioning was not feasible. Negative pressure wound therapy was applied for wound bed preparation and graft fixation. Airtight sealing was obtained using stoma paste around fixation pins and a belt-like silver-containing dressing on raw surfaces, reinforced with stoma paste to create a stable adhesion ridge. These methods enabled sustained negative pressure and stable graft take without regrafting. (1) Safe circumferential debridement achieved by alternating lateral positions. (2) Stoma paste effectively sealed difficult contours. (3) Silver dressing under stoma paste created an antimicrobial, sealable ridge for film adhesion. (4) "Double-sided film sealing" around pins maintained airtight NPWT. This case highlights practical NPWT sealing strategies enabling safe burn care under pelvic external fixation.
C1 [Ohashi, Wakako; Yoneda, Kazuhiro; Kanda, Daisuke; Ueda, Kenichi; Ito, Hiroshi; Takegawa, Ryosuke; Hirose, Tomoya; Sakai, Tomohiko; Oda, Jun] Univ Osaka, Grad Sch Med, Dept Traumatol & Acute Crit Med, 2-15 Yamadaoka, Suita, Osaka 5650871, Japan.
C3 University of Osaka
RP Yoneda, K (通讯作者)，Univ Osaka, Grad Sch Med, Dept Traumatol & Acute Crit Med, 2-15 Yamadaoka, Suita, Osaka 5650871, Japan.
EM yonedak@hp-emerg.med.osaka-u.ac.jp
RI ; Oda, Jun/D-8353-2012; Takegawa, Ryosuke/J-8564-2016
OI Yoneda, Kazuhiro/0009-0008-0980-2313; 
FU General Insurance Association of Japan and ZENKYOREN (National Mutual
   Insurance Federation of Agricultural Cooperatives) Funding Source:
   Medline
CR Barret JP, 2000, BURNS, V26, P487, DOI 10.1016/S0305-4179(99)00182-5
   DOSSETT AB, 1991, J TRAUMA, V31, P888, DOI 10.1097/00005373-199107000-00002
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NR 12
TC 0
Z9 0
U1 1
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAY-JUN
PY 2026
VL 47
IS 3
BP 950
EP 954
DI 10.1093/jbcr/iraf231
EA JAN 2026
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA HL1KB
UT WOS:001659856500001
PM 41410419
DA 2026-07-24
ER
PT J
AU Prete, FP
   De Luca, GM
   Sgaramella, LI
   Poli, E
   Malerba, S
   Puglisi, GR
   Moschou, M
   Saponara, B
   Marano, L
   Gurrado, A
   Coccolini, F
   Catena, F
   Testini, M
AF Prete, Francesco Paolo
   De Luca, Giuseppe Massimiliano
   Sgaramella, Lucia Ilaria
   Poli, Elisabetta
   Malerba, Silvia
   Puglisi, Giuliana Rachele
   Moschou, Maria
   Saponara, Bruna
   Marano, Luigi
   Gurrado, Angela
   Coccolini, Federico
   Catena, Fausto
   Testini, Mario
TI Late closure of the open abdomen in emergency abdomino-pelvic surgery:
   Advanced indications to negative pressure wound therapy?
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Open abdomen; Pelvic trauma;
   Intra-abdominal infection; Enteroatmospheric fistula
ID PRIMARY FASCIAL CLOSURE; ABDOMINAL SEPSIS; DELAYED CLOSURE; SEPTIC
   PATIENTS; MANAGEMENT; CLASSIFICATION; FISTULAS
AB Background Damage control surgery(DCS) is a well-established approach in emergency laparotomy when physiologic instability necessitates an abbreviated operation. In severe intraabdominal infections(IAI), open abdomen(OA) with Negative Pressure Wound Therapy(NPWT) has shown significant efficacy to help reducing morbidity and mortality. Early definitive abdominal closure is recommended to minimize complications, though not always achievable. Methods From 108 cases of DCS and OA with NPWT performed between February 2015 and February 2024, 72 consecutive patients treated for severe IAI were retrospectively reviewed. We comparatively analyzed clinical and perioperative data of patients treated with OA for <= 7 days(short OA) or for > 7 days(long OA), focusing on late OA closure(> 7 days). Primary outcome was overall 30-day survival, secondary outcome the primary fascial closure rate. Results The main indication for OA was abdominal contamination. Fifty-six patients had short OA, 16 long OA. Overall mortality was 23.6%, with APACHE II score the only independent predictor (OR 1.9, 95% CI 1.25-2.92, p = 0.003). Fifty-two patients survived to achieve early closure and 12 late closure, respectively. Overall PFC rate was 92.2% (59 patients), 75% within late closure (p = 0.001). Compared to short OA, in long OA nine patients (56.3%, p < 0.001) experienced intraabdominal complications including enteroatmospheric fistula (EAF-3, 18.8%) and frozen abdomen (7, 43.8%); in 10 patients (87.5%, p < 0.001) NPWT regimen was modified to isolate and divert effluent or clean a contaminated field. Conclusions Late closure of the OA for IAI may significantly associate with EAF and frozen abdomen. In these challenging scenarios NPWT specific properties may be leveraged to address complex anatomical situations, extensive contamination, or the need for targeted wound-healing responses.
C1 [Prete, Francesco Paolo; De Luca, Giuseppe Massimiliano; Sgaramella, Lucia Ilaria; Poli, Elisabetta; Malerba, Silvia; Puglisi, Giuliana Rachele; Moschou, Maria; Gurrado, Angela; Testini, Mario] Univ Bari, Policlin Bari, Acad Div Gen Surg Bonomo, Dept Precis & Regenerat Med & Jonian Area DiMePRe, 11 Piazza Giulio Cesare, I-70124 Bari, Italy.
   [Saponara, Bruna] Univ Bari, Hosp Pharm Serv, Dept Pharmacol, Bari, Italy.
   [Marano, Luigi] Acad Appl Med & Social Sci AMiSNS, Dept Surg, Elblag, Poland.
   [Coccolini, Federico] Pisa Univ Hosp, Gen Emergency & Trauma Surg, Pisa, Italy.
   [Catena, Fausto] Bufalini Hosp, Gen & Emergency Surg, Cesena, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; University of Pisa; Azienda Ospedaliero Universitaria Pisana
RP Sgaramella, LI (通讯作者)，Univ Bari, Policlin Bari, Acad Div Gen Surg Bonomo, Dept Precis & Regenerat Med & Jonian Area DiMePRe, 11 Piazza Giulio Cesare, I-70124 Bari, Italy.
EM ilaria.sgaram@gmail.com
RI Sgaramella, Lucia'Ilaria/LMQ-3099-2024; Coccolini,
   Federico/AAJ-6507-2020; Prete, Francesco/J-7141-2019; Marano,
   Luigi/K-4944-2013; GURRADO, ANGELA/HZM-4980-2023
OI Poli, Elisabetta/0009-0000-6693-9393
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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NR 48
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD DEC 6
PY 2025
VL 21
IS 1
AR 4
DI 10.1186/s13017-025-00660-0
PG 14
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA AZ4VB
UT WOS:001660448000001
PM 41351174
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, ZG
   Shi, CN
   Wu, X
   Zhuang, ZW
   Xu, YQ
   Zhang, ZF
   Qiu, JH
AF Li, Zhigang
   Shi, Chunnan
   Wu, Xiong
   Zhuang, Zhiwei
   Xu, Yongquan
   Zhang, Zefeng
   Qiu, Jinghu
TI A feasibility study of a novel closed flowing vacuum-assisted technique
   (CFVAT) in managing fracture-related infection with implant retention
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Continuous irrigation; Fracture-related infection; Drainage technique;
   Implant retention; CFVAT
AB Objective The Closed Flowing Vacuum-Assisted Technique (CFVAT) is an innovative approach achieving continuous irrigation within a sealed wound environment, which enables active fluid circulation and establishes an efficient flowing-drainage mode under negative pressure. This study aims to conduct the first evaluation comparing the clinical outcomes of CFVAT versus the traditional Vacuum Sealing Drainage (VSD) technique in the management of early (<= 6 weeks) fracture-related infection (FRI) involving internal fixation and classified as Cierny-Mader type II. Methods A retrospective study was conducted on 33 patients with early FRI (<= 6 weeks, Cierny-Mader II) following internal fixation between 2021 and 2024. All patients underwent debridement with retention of internal fixation. The study group (n = 13) received CFVAT, while the control group (n = 20) received VSD. Patient demographics, fracture site, time from initial surgery to infection, inflammatory markers, number of required surgeries, total treatment duration, and costs were compared. Results The primary healing rate was 92.3% in the CFVAT group and 60% in the VSD group. The one-year long-term healing rates were 92.3% and 90%, respectively. The CFVAT group demonstrated advantages in the number of surgeries, treatment duration, and overall cost (P < 0.05). Conclusion For a narrow clinical scenario-specifically early FRI (<= 6 weeks) with retained internal fixation and Cierny-Mader type II anatomy-CFVAT may yield better outcomes than VSD in selected process and cost endpoints. These findings suggest that CFVAT has the potential to achieve wound closure after initial debridement while controlling infection. However, VSD remains a standard adjuvant therapy in FRI care, and the superiority of CFVAT requires validation through prospective randomized controlled trials.
C1 [Li, Zhigang; Shi, Chunnan; Wu, Xiong; Zhuang, Zhiwei; Xu, Yongquan; Zhang, Zefeng; Qiu, Jinghu] Jinjiang Municipal Hosp, Shanghai Peoples Hosp Fujian 6, Dept Traumat Orthoped, Jinjiang 362200, Fujian, Peoples R China.
RP Li, ZG (通讯作者)，Jinjiang Municipal Hosp, Shanghai Peoples Hosp Fujian 6, Dept Traumat Orthoped, Jinjiang 362200, Fujian, Peoples R China.
EM dslzg@163.com
RI Shi, Chunnan/KIK-5950-2024; Li, Zhigang/PHE-4609-2026
OI Shi, Chunnan/0000-0001-5820-5349; 
FU Cooperative Innovation Project of Jinjiang Municipal Hospital (Shanghai
   Sixth People's Hospital, Fujian); Huaqiao University [YX2024007]
FX This study was supported by the Cooperative Innovation Project of
   Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital, Fujian)
   and Huaqiao University (No. YX2024007) awarded to Li Zhigang. The
   funders played no role in the design, conduct, or reporting of this
   study.
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NR 33
TC 0
Z9 0
U1 3
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD JAN 14
PY 2026
VL 21
IS 1
AR 36
DI 10.1186/s13018-025-06489-2
PG 15
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CD3LW
UT WOS:001663080000003
PM 41535948
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Adeli, S
AF Adeli, Shamisa
TI Impact of multilayer compression bandages on subdressing pressure
   generated by a sNPWT: an experimental study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE chronic; compression bandage; hard-to-heal; single-use negative pressure
   wound therapy; venous leg ulcer; wound; wound care; wound dressing;
   wound healing
ID LEG ULCERS; THERAPY
AB Objective: Venous leg ulcers (VLU) are a common, recurring condition resulting from venous stasis; they are especially prevalent in Northern Europe and the US. The overall prevalence of this condition is 1%, rising to 3% in patients >65 years of age. This study analysed the effect of a combination of single-use negative pressure wound therapy (sNPWT, VivereX NPWT system (Sunmedic AB, V & auml;llinge, Sweden) and compression bandaging (CB) in the treatment of VLUs. Method: An experimental in vivo extremity model was used to monitor and validate sub-dressing pressure. Results: There was no effect of the multilayer CB on the sNPWT therapeutical pressure. To the best of the author's knowledge, this is the first experimental study to examine variations in sub-dressing pressure within sNPWT systems following the application of a CB. Conclusion: In this study, therapeutical pressure induced by the VivereX device remained unaffected when used in combination with multilayer CB in the treatment of VLUs.
C1 [Adeli, Shamisa] Akad Hosp, Uppsala, Sweden.
C3 Uppsala University; Uppsala University Hospital
RP Adeli, S (通讯作者)，Akad Hosp, Uppsala, Sweden.
EM Shamsia.adeli@gmail.com
CR Abouelhassan AE, Study of effect of four layer compression bandage versus four layer compression bandage with negative pressure wound therapy
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2026
VL 35
IS 1
BP 86
EP 88
DI 10.12968/jowc.2024.0036
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CG6PA
UT WOS:001665330000001
PM 41528786
DA 2026-07-24
ER
PT J
AU Ling, SNW
   Kuan, NLK
   Abraham, M
   Jack, PW
   Leong, KLB
AF Ling, Stacy Ng Wei
   Kuan, Nicole Lee Kim
   Abraham, Mini
   Jack, Pan Woei
   Leong, Kevin Lim Boon
TI Negative pressure wound therapy in paediatric scoliosis surgery: a pilot
   study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE 3M Prevena; fusion; negative pressure wound therapy; paediatric
   patients; prophylaxis; scoliosis; surgical site infection; negative
   wound; wound care; wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; ADOLESCENT IDIOPATHIC SCOLIOSIS; INSTRUMENTED
   SPINAL-FUSION; INFECTION; CHILDREN; DEHISCENCE; MANAGEMENT; INCISIONS
AB Objective: To evaluate the use of negative pressure wound therapy (NPWT) in healing closed spinal incisions following scoliosis deformity surgery in a paediatric cohort. Method: A retrospective review of patients <21 years of age who underwent posterior spinal instrumentation and fusion for severe scoliosis between 2019-2022. Patients were divided into two groups. The first comprised patients with idiopathic scoliosis (IS) treated with 3M Prevena (SolventumUS) application (Group P-IS). They were compared against a matched group who received standard dressings (Group S-IS). The second group comprised patients with non-idiopathic scoliosis (NIS) treated with 3M Prevena application (Group P-NIS), and who were compared against a matched group who received standard dressings (Group S-NIS). Results: The first group had a total of 31 patients (Group P-IS) who were compared to 35 patients (Group S-IS). Seroma formation, wound dehiscence, surgical site infections (SSIs), duration of hospitalisation and the number of visits until complete wound healing was higher in Group S-IS, although statistical significance (p<0.05) was not reached. In the second group, a total of 17 patients (Group P-NIS) were compared against 13 patients (Group S-NIS). Seroma formation, duration of hospitalisation and number of visits until complete wound healing was higher in Group S-NIS. Conclusion: In this study, NPWT following primary closure in scoliosis surgery resulted in reduced seroma formation, wound dehiscence and SSIs in patients with IS, and reduced seroma formation in NIS patients. NPWT was beneficial in augmenting wound healing following paediatric spinal surgery and should be further examined in larger-scale prospective studies.
C1 [Ling, Stacy Ng Wei; Abraham, Mini; Jack, Pan Woei; Leong, Kevin Lim Boon] KK Womens & Childrens Hosp, Dept Orthopaed Surg, 100 Bukit Timah Rd, Singapore, Singapore.
   [Kuan, Nicole Lee Kim] KK Womens & Childrens Hosp, Div Surg, 100 Bukit Timah Rd, Singapore, Singapore.
C3 KK Women's & Children's Hospital; KK Women's & Children's Hospital
RP Ling, SNW (通讯作者)，KK Womens & Childrens Hosp, Dept Orthopaed Surg, 100 Bukit Timah Rd, Singapore, Singapore.
EM stace.ng@gmail.com
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
   Akhtar MA, 2016, SPINE J, V16, pS59, DOI [10.1016/j.spinee.2016.01.066, 10.1016/j.spinee.2016.01.066, DOI 10.1016/J.SPINEE.2016.01.066]
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NR 28
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2026
VL 35
IS 1
BP 68
EP 74
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CG6PI
UT WOS:001665330800001
PM 41528794
DA 2026-07-24
ER
PT J
AU Huang, TH
   Huang, HP
AF Huang, Taihua
   Huang, Haiping
TI Application effect of vacuum sealing drainage combined with nano-silver
   dressings in the treatment of non-healing wounds after surgery for open
   limb fractures
SO JOURNAL OF ORTHOPAEDIC SCIENCE
LA English
DT Article
DE Vacuum sealing drainage; Nano-silver dressings; Fracture; Non-healing
   wound; Inflammatory factors; Scar proliferation
ID EFFICACY
AB Background Non-healing wounds after open limb fracture surgery pose clinical challenges, requiring effective management; vacuum sealing drainage (VSD) promotes healing by removing exudate and stimulating granulation, while nano-silver dressings provide antimicrobial protection to reduce infection risk. We aimed to probe the application effect of VSD combined with nano-silver dressings in the treatment of non-healing wounds after surgery for Gustilo type III open limb fractures. Methods A total of 60 patients with non-healing wounds after surgery for Gustilo type III open limb fractures were randomly divided into two groups, with 30 cases in each group. The control group received conventional therapy, and the study group received VSD combined with nano-silver dressings. Before treatment and after 7 days of treatment, inflammatory cytokines (C-reactive protein (CRP) and procalcitonin (PCT)) in serum and growth factors (transforming growth factor beta1 (TGF-beta 1) and vascular endothelial growth factor (VEGF)) in wound exudate were measured using enzyme-linked immunosorbent assay. The pain level of the patients was measured by the Visual Analogue Scale (VAS). Patients' skin quality was assessed by the Vancouver Scar Scale (VSS), and the efficacy of trauma treatment was observed in both groups. Results After 7-day treatment, the study group performed lower levels of CRP and PCT, higher levels of TGF-beta 1 and VEGF, lower VAS scores and VSS scores, and better overall treatment rate compared to the control group (all P < 0.05). Conclusion VSD combined with nano-silver dressings has good therapeutic efficacy in non-healing wounds after surgery for open limb fractures and can inhibit inflammatory response and improve skin quality. (c) 2025 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Huang, Taihua; Huang, Haiping] Mianyang Orthoped Hosp, Dept Knee Joint, 158 South Sect Changhong Ave, Mianyang 621000, Sichuan, Peoples R China.
RP Huang, TH (通讯作者)，Mianyang Orthoped Hosp, Dept Knee Joint, 158 South Sect Changhong Ave, Mianyang 621000, Sichuan, Peoples R China.
EM Huangtaihua2868@163.com
CR Aggarwal Kanika, 2021, J Indian Soc Periodontol, V25, P504, DOI [10.4103/jisp.jisp_17_21, 10.4103/jisp.jisp_17_21]
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   Yuan YC, 2022, INT J BIOL MACROMOL, V194, P644, DOI 10.1016/j.ijbiomac.2021.11.108
NR 27
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0949-2658
EI 1436-2023
J9 J ORTHOP SCI
JI J. Orthop. Sci.
PD JAN
PY 2026
VL 31
IS 1
BP 207
EP 212
DI 10.1016/j.jos.2025.05.012
EA JAN 2026
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CG6YN
UT WOS:001665354700001
PM 40675903
DA 2026-07-24
ER
PT J
AU Wu, CJ
   Tsai, YC
   Li, YC
   Su, MS
   Chou, YY
   Tsao, MC
   Tzeng, YS
AF Wu, Chien-Ju
   Tsai, Yu-Chi
   Li, Yi-Chen
   Su, Ming-Shan
   Chou, Yu-Yu
   Tsao, Ming-Cheng
   Tzeng, Yuan-Sheng
TI Is Primary Closure Safe and Effective for Sacral Pressure Ulcers?
   Single-Surgeon Experience With Negative Pressure Wound Therapy in a
   Medical Center and a Regional Hospital
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE closed-incision negative pressure wound therapy (CI-NPWT); negative
   pressure wound therapy (NPWT); primary closure; sacral pressure ulcer;
   tension-reducing wound closure; wound reconstruction
AB BackgroundSacral pressure ulcers present a major reconstructive challenge, especially in elderly and bedridden patients. Although negative pressure wound therapy (NPWT) has been widely used in wound management, its integration into surgical protocols for pressure ulcer closure is underreported in midlevel medical centers. We aimed to evaluate the safety, efficacy, and reproducibility of a streamlined surgical strategy for sacral pressure ulcers combining debridement, primary closure, and closed-incision-NPWT (CI-NPWT) and examine the outcomes in patients treated in 2 institutional settings with different resource levels.MethodsThis retrospective observational cohort study included 35 patients (median age, 76 years; 66% female) with stage III-IV sacral pressure ulcers who underwent surgical reconstruction using a standardized approach involving debridement, tension-reducing wound closure, and CI-NPWT. All procedures were performed by a single reconstructive surgeon at both a medical center and a regional hospital.ResultsAmong the 35 patients, 33 were treated at the tertiary center and 2 at the regional hospital. The median wound size was 9 x 6 cm (range 3 x 5-13 x 12 cm). Most patients were elderly with multiple comorbidities. CI-NPWT effectively supported primary wound closure with no major complications. Minor wound-edge dehiscence occurred in a few patients and was managed conservatively. All wounds healed completely.ConclusionA simple and consistent surgical protocol combining primary closure with CI-NPWT is safe, effective, and reproducible in both medical center and regional hospital settings.
C1 [Tsai, Yu-Chi; Li, Yi-Chen; Tzeng, Yuan-Sheng] Natl Def Med Univ, Div Plast & Reconstruct Surg, Sumsun, Turkiye.
   [Li, Yi-Chen] Natl Def Med Univ, Triserv Gen Hosp, Dept Surg, Div Traumatol, Taipei, Taiwan.
   [Su, Ming-Shan; Tsao, Ming-Cheng; Tzeng, Yuan-Sheng] Zuoying Armed Forces Gen Hosp, Dept Surg, Div Plast Surg, Hamilton, ON, Canada.
   [Chou, Yu-Yu; Tzeng, Yuan-Sheng] Zuoying Armed Forces Gen Hosp, Dept Gen Surg, Kaohsiung, Taiwan.
C3 Samsun Training & Research Hospital; Tri-Service General Hospital;
   National Defense Medical University; McMaster University
RP Tzeng, YS (通讯作者)，Dept Surg, Div Plast & Reconstruct Surg, 325,Sect 2,Cheng Gung Rd, Taipei 11490, Taiwan.
EM wuchienjud33d3@edusbm.com; yuchitsaif47jh6@edusbm.com;
   yichenlig5h78@edusbm.com; mingshansu3d56@edusbm.com;
   yuyuchoufg5h8@edusbm.com; mingchengtsao3d67@edusbm.com;
   yuanshengtzengg676@edusbm.com
RI Tzeng, Yuan-sheng/AAD-8843-2020
FU Tri-Service General Hospital [TSGH_E_114288]
FX Funding source: This work was supported by the Tri-Service General
   Hospital (TSGH_E_114288).
CR Argenta LC., 1997, Plast Reconstr Surg, V100, P553
   Chang CK, 2017, INT WOUND J, V14, P1170, DOI 10.1111/iwj.12781
   Chen CY, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023022
   Gombert A., 2017, Int Wound J, V14, P405
   Hsu KF, 2022, J PERS MED, V12, DOI 10.3390/jpm12020182
   National Pressure Injury Advisory Panel (NPIAP), 2019, The International Guideline
   Ousey K., 2019, J Wound Care, V28, pS1
   Ousey K., 2016, Int Wound J, V13, P19
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Stannard JP., 2006, J Orthop Trauma, V20, P723
NR 10
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2026
VL 96
IS 2
BP 174
EP 178
DI 10.1097/SAP.0000000000004625
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CM3WX
UT WOS:001669226100004
PM 41490225
DA 2026-07-24
ER
PT J
AU Villalba-Aguilar, C
   Carmona-Torres, JM
   Villalba-Aguilar, L
   Castillo-Hermoso, MI
   Molina-Madueño, RM
   Laredo-Aguilera, JA
AF Villalba-Aguilar, Celia
   Carmona-Torres, Juan Manuel
   Villalba-Aguilar, Lucia
   Castillo-Hermoso, Matilde Isabel
   Molina-Madueno, Rosa Maria
   Laredo-Aguilera, Jose Alberto
TI Effectiveness of Negative Pressure Wound Therapy in Burns in Pediatric
   and Adolescent Patients: A Systematic Review and Meta-Analysis
SO HEALTHCARE
LA English
DT Review
DE burn; child; negative pressure wound therapy; scar; graft; cost
ID VACUUM-ASSISTED CLOSURE; INJURIES; COSTS; CARE
AB Background: Burns represent a public health problem because they generate both physical and psychological damage, especially in the child and adolescent population, and high costs, especially due to the management of scars. Advances in burn care have improved survival and quality of life for this population. New clinical trials have been conducted on the benefits of negative pressure wound therapy (NPWT), showing that it improves the healing of burns and the appearance of scars. Therefore, this study aims to analyze the efficacy of NPWT both alone and as an adjunct to conventional dressings in pediatric and adolescent patients compared with conventional treatments. Methodology: A systematic search was carried out between December 2023 and the last quarter of 2025 in databases such as PubMed, Scopus, CINAHL, and the Cochrane Library. This meta-analysis was performed following the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and was registered in PROSPERO with registration number CRD42024597293. The risk of bias 2 (RoB2) tool was used to assess the risk of bias in the studies. Quantitative meta-analyses using random-model effects were performed only for variables with sufficient comparable data among studies. For other outcomes, where meta-analysis was not feasible due to lack of comparable data or control groups, results were synthesized qualitatively. Results: A total of seven articles (three clinical trials and four retrospective studies), in which a total of 323 subjects participated, were included. The main results demonstrate the efficacy of NPWT, as it decreases the re-epithelialization time, improves the appearance of scars (MD = -1.25 (95% CI between -1.80 and -0.70)), reduces the probability of skin grafts (OR = 0.17 (95% CI between 0.06 and 0.46)), and therefore, as there is less need for surgery and fewer dressing changes, reduces costs. Conclusions: NPWT offers significant clinical benefits in the treatment of burns in children and adolescents. Although a meta-analysis could not be performed due to the lack of a control group in some studies, studies with larger samples and multicenter designs will be necessary to better assess the relevant clinical outcomes. However, the results of this study show that NPWT is effective in treating burns in children and adolescents and that its use in clinical practice may represent a promising adjunctive therapy.
C1 [Villalba-Aguilar, Celia] Hosp Laboral Solimat, Calle San Pedro el Verde 35, Toledo 45004, Spain.
   [Villalba-Aguilar, Celia; Carmona-Torres, Juan Manuel; Castillo-Hermoso, Matilde Isabel; Molina-Madueno, Rosa Maria; Laredo-Aguilera, Jose Alberto] Univ Castilla La Mancha, Fac Fisioterapia & Enfermeria Toledo, Avda Carlos 3 S-N, Toledo 45071, Spain.
   [Carmona-Torres, Juan Manuel; Laredo-Aguilera, Jose Alberto] Univ Castilla La Mancha, Grp Invest Multidisciplinar Cuidados IMCU, Avda Carlos 3 S-N, Toledo 45071, Spain.
   [Carmona-Torres, Juan Manuel; Laredo-Aguilera, Jose Alberto] Inst Invest Sanitaria Castilla La Mancha IDISCAM, Finca Peraleda S-N, Toledo 45004, Spain.
   [Villalba-Aguilar, Lucia] Univ Rey Juan Carlos, Fac Ciencias Salud, Alcorcon 28922, Spain.
   [Castillo-Hermoso, Matilde Isabel] Hosp Nacl Paraplej, Finca Peraleda S-N, Toledo 45004, Spain.
C3 Universidad de Castilla-La Mancha; Universidad de Castilla-La Mancha;
   Universidad Rey Juan Carlos; Hospital Nacional de Paraplejicos
RP Carmona-Torres, JM (通讯作者)，Univ Castilla La Mancha, Fac Fisioterapia & Enfermeria Toledo, Avda Carlos 3 S-N, Toledo 45071, Spain.; Carmona-Torres, JM (通讯作者)，Univ Castilla La Mancha, Grp Invest Multidisciplinar Cuidados IMCU, Avda Carlos 3 S-N, Toledo 45071, Spain.; Carmona-Torres, JM (通讯作者)，Inst Invest Sanitaria Castilla La Mancha IDISCAM, Finca Peraleda S-N, Toledo 45004, Spain.
EM celia.villalba@alu.uclm.es; juanmanuel.carmona@uclm.es;
   luciavillalbaaguilar12@gmail.com; matildei.castillo@uclm.es;
   rosam.molina@uclm.es; josealberto.laredo@uclm.es
RI Carmona-Torres, Juan/E-1579-2018; Laredo, José/ABR-3810-2022; Castillo
   Hermoso, Matilde/LTF-0979-2024
OI Villalba Aguilar, Celia/0009-0003-2766-224X; Molina Madueño, Rosa
   María/0000-0002-5085-8377
CR Adham A, 2022, EGYPT J SURG, V41, P354, DOI 10.4103/ejs.ejs_374_21
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NR 52
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD JAN 19
PY 2026
VL 14
IS 2
AR 242
DI 10.3390/healthcare14020242
PG 23
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA CO3IB
UT WOS:001670544700001
PM 41595378
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hepa-Banasik, A
   Szatan, M
   Slabon, A
   Lach, J
   Wielgórecki, A
   Czerny-Bednarczyk, K
   Labus, W
AF Hepa-Banasik, Anna
   Szatan, Magdalena
   Slabon, Anna
   Lach, Jaroslaw
   Wielgorecki, Artur
   Czerny-Bednarczyk, Katarzyna
   Labus, Wojciech
TI Holistic Therapy in a Patient with Necrotic Ulcer Caused by the Bite of
   Brazilian Wandering Spider: A Case Report of Challenging Treatment with
   Combined Therapies
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE chronic wound; spider bite; acellular dermal matrix; split thickness
   skin graft; microperfusion
ID MECHANISMS; ADULTS; VENOM
AB Hard-to-heal wounds remain a significant challenge for healthcare professionals, particularly in aging populations. Although most chronic wounds are associated with diabetes or chronic venous insufficiency, rare etiologies should also be considered. One such cause is envenomation by Phoneutria spp. (native to South America, rare in Europe). Their venom contains potent neurotoxins. While systemic manifestations are more commonly reported, localized necrotic skin lesions may also occur. This case report presents a rare chronic wound following a suspected Phoneutria spider bite and highlights the importance of an individualized, multimodal treatment approach. A 61-year-old male patient with a progressive thigh wound following a spider bite sustained during work. Despite initial self-treatment and pharmacotherapy the wound deteriorated. The patient was admitted to the authors' facility, where surgical treatment included necrosectomy and a sandwich graft using an acellular dermal matrix combined with a split-thickness skin graft. Adjunctive therapies included negative pressure wound therapy and hyperbaric oxygen therapy. After discharge, outpatient wound care was continued. Treatment was monitored with photographic documentation and serial microperfusion measurements. Complete wound closure was achieved after 4 months of specialized therapy. Management of chronic wounds requires a multidisciplinary and individualized approach with surgical intervention, advanced wound care and specialized outpatient follow-up.
C1 [Hepa-Banasik, Anna; Szatan, Magdalena; Slabon, Anna; Lach, Jaroslaw; Wielgorecki, Artur; Czerny-Bednarczyk, Katarzyna; Labus, Wojciech] Stanislaw Sakiel Burn Treatment Ctr Siemianowice S, Jana Pawla II St 2, PL-41100 Siemianowice Slaskie, Poland.
   [Hepa-Banasik, Anna; Szatan, Magdalena; Slabon, Anna] Med Univ Silesia, Fac Hlth Sci Bytom, Doctoral Sch, PL-41902 Bytom, Poland.
C3 Medical University of Silesia
RP Hepa-Banasik, A; Slabon, A (通讯作者)，Stanislaw Sakiel Burn Treatment Ctr Siemianowice S, Jana Pawla II St 2, PL-41100 Siemianowice Slaskie, Poland.; Hepa-Banasik, A; Slabon, A (通讯作者)，Med Univ Silesia, Fac Hlth Sci Bytom, Doctoral Sch, PL-41902 Bytom, Poland.
EM anna.hepa@clo.com.pl; anna.slabon@clo.com.pl;
   artur.wielgorecki@clo.com.pl; wojciech.labus@clo.com.pl
RI Łabuś, Wojciech/I-3141-2019
OI Łabuś, Wojciech/0000-0003-2108-9270
CR [Anonymous], Polskie Towarzystwo Geriatryczne Cukrzyca u osob w wieku podeszlym. Cz. 1.
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN 15
PY 2026
VL 15
IS 2
AR 693
DI 10.3390/jcm15020693
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CO5QJ
UT WOS:001670701500001
PM 41598629
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Astasio-Picado, A
   Jurado-Palomo, J
   Pozo-Aranda, B
   Cobos-Moreno, P
AF Astasio-Picado, Alvaro
   Jurado-Palomo, Jesus
   Pozo-Aranda, Belen
   Cobos-Moreno, Paula
TI Comparative Evidence on Negative Pressure Therapy and Hyperbaric Oxygen
   Therapy for Diabetic Foot Ulcers: A Systematic Review of Independent
   Effectiveness and Clinical Applicability
SO MEDICINA-LITHUANIA
LA English
DT Review
DE diabetic foot ulcer; negative pressure therapy; hyperbaric oxygen
   therapy; wound healing; amputation prevention
ID WOUND THERAPY; METAANALYSIS
AB Background and Objectives: To evaluate and synthesize evidence on the independent clinical effectiveness, safety, and applicability of Negative Pressure Wound Therapy (NPWT) and Hyperbaric Oxygen Therapy (HBOT) in diabetic foot ulcers (DFUs), and to determine whether current evidence allows for a direct comparison between both interventions: NPWT and HBOT are widely advanced therapies for DFUs. Although both show benefits, the relative superiority of one over the other remains unclear. Systematic review of the literature conducted in accordance with PRISMA guidelines. Materials and Methods: A comprehensive literature search was performed using two electronic databases. The review included randomized controlled trials, systematic reviews, meta-analyses, and non-randomized studies. Methodological quality and risk of bias were assessed using validated tools: RoB 2.0 for randomized trials, AMSTAR-2 for systematic reviews, and ROBINS-I for non-randomized studies. Results: A total of 22 studies were included. NPT was shown to be effective in accelerating wound healing, though results varied depending on the type of intervention and clinical context. HBOT demonstrated beneficial effects on angiogenesis and significantly reduced the rate of major amputations. Both therapies presented significant advantages in the management of diabetic foot ulcers. Conclusions: Negative pressure therapy and hyperbaric oxygen therapy are both effective treatments for diabetic foot ulcer healing. However, treatment selection should be individualized based on patient-specific clinical factors, ulcer severity, and available healthcare resources. Integrating these advanced therapies within a multidisciplinary care approach may optimize outcomes and reduce the risk of complications. Future research should include standardized, head-to-head RCTs.
C1 [Astasio-Picado, Alvaro; Jurado-Palomo, Jesus; Pozo-Aranda, Belen] Univ Castilla La Mancha, Fac Hlth Sci, Physiotherapy Nursing & Physiol Dept, Toledo 45600, Spain.
   [Astasio-Picado, Alvaro; Cobos-Moreno, Paula] Univ Extremadura, Univ Ctr Plasencia, Dept Nursing, Caceres 10600, Spain.
C3 Universidad de Castilla-La Mancha; Universidad de Extremadura
RP Astasio-Picado, A (通讯作者)，Univ Castilla La Mancha, Fac Hlth Sci, Physiotherapy Nursing & Physiol Dept, Toledo 45600, Spain.; Astasio-Picado, A (通讯作者)，Univ Extremadura, Univ Ctr Plasencia, Dept Nursing, Caceres 10600, Spain.
EM alvaro.astasio@uclm.es
RI Astasio-Picado, Alvaro/Y-3530-2019; cobos moreno, paula/HKF-0874-2023;
   Jurado-Palomo, Jesús/PJT-1779-2026
OI Astasio-Picado, Alvaro/0000-0001-9915-0567; 
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NR 50
TC 0
Z9 0
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JAN 4
PY 2026
VL 62
IS 1
AR 109
DI 10.3390/medicina62010109
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CO8EN
UT WOS:001670873500001
PM 41597395
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hayasaka, M
   Landy, HJ
   Forbes, L
   Barger, A
   Gangii, SN
   Saade, G
   Kawakita, T
AF Hayasaka, Misa
   Landy, Helain J.
   Forbes, Lauren
   Barger, Abigail
   Gangii, Salimah Navaz
   Saade, George
   Kawakita, Tetsuya
TI Surgical site infections after cesarean delivery
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Review
DE cesarean delivery; surgical site infection; wound complications;
   endometritis; necrotizing soft tissue infection
ID ADJUNCTIVE AZITHROMYCIN PROPHYLAXIS; SOFT-TISSUE INFECTIONS; PRESSURE
   WOUND THERAPY; SAFETY CHECKLIST; RISK-FACTORS; POSTPARTUM ENDOMETRITIS;
   ANTIBIOTIC-THERAPY; DISEASES SOCIETY; EXTREME OBESITY; UNITED-STATES
AB Surgical site infections represent a persistent and clinically relevant complication of cesarean delivery, contributing substantially to postpartum morbidity, hospital readmission, and pregnancy-related mortality. As cesarean delivery has escalated to the most common major operation worldwide-now comprising 21% of global births and 32% in the United States-the burden of postcesarean surgical site infections, reported in 3% to 15% of cases, remains unacceptably high despite advances in perioperative antisepsis, antibiotic prophylaxis, and prevention bundles. This review provides an updated comprehensive overview of postcesarean SSIs, including their definitions, risk factors, microbiology, clinical presentation, evaluation, prevention strategies, and management. Postcesarean surgical site infections are classified as superficial incisional, deep incisional, organ/space infections such as postpartum endometritis, and necrotizing soft tissue infections. The microbiologic spectrum varies by infection type and includes both monomicrobial and polymicrobial pathogens. Clinical presentations range from localized incisional symptoms to systemic signs, with necrotizing soft tissue infections requiring urgent recognition due to their aggressive clinical course and high mortality. Key risk factors include prolonged rupture of membranes, labor, higher body mass index, intraamniotic infection, and longer operative time. Prevention necessitates a multifaceted approach. In the preoperative phase, interventions include patient preparation and operative field antisepsis. Intraoperative strategies focus on surgical technique. Postoperative care centers on appropriate antibiotic prophylaxis and wound management. For established surgical site infections, the cornerstone of management is timely incision and drainage. Meticulous wound care, often involving serial dressing changes or negative pressure wound therapy, supports appropriate healing. Targeted antibiotic therapy is initiated when systemic signs or extensive local findings are present and is tailored to the specific clinical scenario. Addressing surgical site infections associated with cesarean delivery requires a comprehensive, multidisciplinary, and evidence-based approach. A sustained commitment to optimizing and implementing refined protocols is imperative to improve maternal infectious outcomes.
C1 [Hayasaka, Misa; Forbes, Lauren; Barger, Abigail; Gangii, Salimah Navaz; Saade, George; Kawakita, Tetsuya] Old Dominion Univ ODU, Dept Obstet & Gynecol, Macon & Joan Brock Virginia Hlth Sci, Norfolk, VA 23529 USA.
   [Landy, Helain J.] MedStar Georgetown Univ Hosp, Obstet & Gynecol, Washington, DC USA.
C3 Georgetown University
RP Kawakita, T (通讯作者)，Old Dominion Univ ODU, Dept Obstet & Gynecol, Macon & Joan Brock Virginia Hlth Sci, Norfolk, VA 23529 USA.
EM tetsuya.x.kawakita@gmail.com
RI Kawakita, Tetsuya/H-7559-2019; Landy, Helain/AAC-4016-2019
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NR 130
TC 0
Z9 0
U1 2
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JAN
PY 2026
VL 233
IS 6
SU S
BP S524
EP S540
DI 10.1016/j.ajog.2025.08.008
EA JAN 2026
PG 17
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CT0IE
UT WOS:001673733000022
PM 41485839
OA Bronze
DA 2026-07-24
ER
PT J
AU Feng, X
   Ma, C
   Zhang, ZH
   Xu, L
   Fang, YD
AF Feng, Xia
   Ma, Chao
   Zhang, Zhihui
   Xu, Lei
   Fang, Yudong
TI Sequential application of vacuum sealing drainage and antibiotic-loaded
   bone cement for the successful treatment of a diabetic ischemic foot
   ulcer: a case report
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE antibiotic delivery; antibiotic-loaded bone cement; case report;
   diabetic foot ulcer; ischemia; vacuum sealing drainage; wound healing
AB Background Diabetic foot ulcers (DFUs), particularly those with ischemic components, present a major therapeutic challenge due to poor perfusion, high infection risk, and delayed wound healing. Conventional treatments often fail to achieve satisfactory outcomes in complex cases. Vacuum sealing drainage (VSD) has shown promise in wound healing by enhancing angiogenesis, stimulating granulation tissue formation, and reducing bacterial colonization while antibiotic-loaded bone cement (ALBC) offers localized, high-concentration antimicrobial delivery. However, the sequential application of these two modalities is rarely reported in ischemic DFUs.Case presentation We report the case of a 78-year-old female with type 2 diabetes mellitus who presented with a chronic, infected, ischemic foot ulcer that was unresponsive to standard wound care and systemic antibiotics. Surgical debridement was performed, followed by the application of VSD to enhance granulation tissue formation and maintain negative pressure drainage. Antibiotic-loaded bone cement was subsequently applied to fill the wound cavity and control local infection. Over the subsequent weeks, sequential application of VSD and ALBC resulted in remarkable improvement of the ulcer, ultimately achieving complete wound healing without the need for revascularization or major amputation.Conclusion This case demonstrates that the sequential application of VSD and ALBC may offer a synergistic therapeutic strategy for the management of complex diabetic ischemic ulcers. This approach may provide an effective alternative in cases where infection control and wound healing are otherwise difficult to achieve.
C1 [Feng, Xia; Ma, Chao; Zhang, Zhihui; Xu, Lei; Fang, Yudong] Shanghai Univ Tradit Chinese Med, Shanghai TCM Integrated Hosp, Dept Vasc Dis 1, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Xu, L; Fang, YD (通讯作者)，Shanghai Univ Tradit Chinese Med, Shanghai TCM Integrated Hosp, Dept Vasc Dis 1, Shanghai, Peoples R China.
EM xulei13917692080@163.com; 13301901601@163.com
FU Shanghai Municipal Health Commission [(No. 2024QN010]
FX The author(s) declared that financial support was received for this work
   and/or its publication. This work was supported by the Shanghai
   Municipal Health Commission Traditional Chinese Medicine Research
   Project (No. 2024QN010), the National Natural Science Foundation of
   China (No. 8217151861), and the Three-Year Action Plan for Strengthening
   the Excellence of Traditional Chinese Medicine in Hongkou District of
   Shanghai (HKGYQYXM-2022-07). The Second Batch of Central Government
   Transfer Payments in 2025 for the Improvement of Medical Service and
   Health Security Capacity (Inheritance and Development of Traditional
   Chinese Medicine) - Major and Difficult Disease Integrated Traditional
   Chinese and Western Medicine Clinical Collaboration Project (No.
   ZDYN-2024-A-142).
CR Armstrong DG, 2023, JAMA-J AM MED ASSOC, V330, P62, DOI 10.1001/jama.2023.10578
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NR 22
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 16
PY 2026
VL 16
AR 1735952
DI 10.3389/fendo.2025.1735952
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CT3AL
UT WOS:001673915700001
PM 41625239
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Seswandhana, MR
   Gunadi
   Anwar, SL
   Aryandono, T
   Dachlan, I
   Mulyono, B
   Widodo, I
   Wirohadidjojo, YW
   Sukma, MPL
   Adhityo, P
AF Seswandhana, Muhammad Rosadi
   Gunadi
   Anwar, Sumadi L.
   Aryandono, Teguh
   Dachlan, Ishandono
   Mulyono, Budi
   Widodo, Irianiwati
   Wirohadidjojo, Yohanes W.
   Sukma, Mokhammad P. L.
   Adhityo, Pramana
TI The role of negative pressure wound therapy on TGF-β1, MMP-9, α-SMA, and
   collagen type III in preventing burn contractures in a porcine model
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Negative pressure; wound therapy (NPWT); Wound healing; Burn management;
   Cytokines; Wound contraction
ID METALLOPROTEINASES; MECHANISM; MATRIX; INJURY
AB Introduction: Burns are a leading cause of disability and death, requiring prolonged hospitalization and high costs that impair daily activities. Wound healing involves cytokines and growth factors. Despite various treatments, ideal wound dressing remains unidentified. Negative pressure wound therapy (NPWT) has shown potential as an ideal wound healing environment. We compared saline dressings, silver sulfadiazine, intermittent NPWT, and continuous NPWTon wound contraction, re-epithelialization, and biomarkers (MMP-9, TGF-beta 1, alpha-SMA, and COL3) in a porcine deep dermal burn model. Methods: Six male Yorkshire pigs received 20 burns and were treated with NaCl 0.9% dressings, silver sulfadiazine, intermittent, or continuous NPWT. Wound healing was assessed on days 1, 3, 7, 14, and 21. MMP-9 and TGF-beta 1 were analyzed using ELISA, alpha-SMA, and COL3 using immunohistochemistry. Statistical analyses included linear regression, ANOVA, post-hoc tests, and path analyses. Results: Intermittent NPWT showed the lowest wound contraction on days 14 and 21 (p < 0.001) and highest re-epithelialization on day-21 (p=0.0027). MMP-9 and TGF-beta 1 levels were significantly elevated in both NPWT groups across most time points (days 1, 3, 7, and 14), with TGF-beta 1 peaking in the NaCl group on day-21. Significant alpha-SMA histoscores differences appeared on day 3, while COL3 differences were significant on day-14. Conclusions: NPWT may reduce wound contraction and accelerates re-epithelialization without impairing wound healing, confirmed by modulation of MMP-9, TGF beta 1, alpha-SMA, and COL3, suggesting the potential to minimize contracture scar formation. (c) 2026 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Seswandhana, Muhammad Rosadi; Dachlan, Ishandono] Univ Gadjah Mada, Dr Sardjito Hosp, Plast Reconstruct & Aesthet Surg Div, Fac Med Publ Hlth & Nursing,Dept Surg, Jl Kesehatan 1, Yogyakarta 55281, Indonesia.
   [Gunadi] Univ Gadjah Mada, Dr Sardjito Hosp, Fac Med Publ Hlth & Nursing,Translat Res Unit, Dept Surg,Pediat Surg Div,Genet Working Grp, Yogyakarta 55281, Indonesia.
   [Anwar, Sumadi L.; Aryandono, Teguh] Univ Gadjah Mada, Dr Sardjito Hosp, Fac Med Publ Hlth & Nursing, Dept Surg,Div Surg Oncol, Yogyakarta 55281, Indonesia.
   [Mulyono, Budi] Univ Gadjah Mada, Fac Med Publ Hlth & Nursing, Clin Pathol Dept, Jl Farmako, Yogyakarta 55281, Indonesia.
   [Widodo, Irianiwati] Univ Gadjah Mada, Dr Sardjito Hosp, Fac Med Publ Hlth & Nursing, Dept Pathol, Yogyakarta 55281, Indonesia.
   [Wirohadidjojo, Yohanes W.] Univ Gadjah Mada, Dr Sardjito Gen Hosp, Fac Med Publ Hlth & Nursing, Dept Dermatol & Venereol, Yogyakarta 55281, Indonesia.
   [Sukma, Mokhammad P. L.; Adhityo, Pramana] Univ Gadjah Mada, Dr Sardjito Hosp, Fac Med Publ Hlth & Nursing, Dept Surg, Yogyakarta 55281, Indonesia.
C3 Central General Hospital Dr. Sardjito; Gadjah Mada University; Gadjah
   Mada University; Central General Hospital Dr. Sardjito; Gadjah Mada
   University; Central General Hospital Dr. Sardjito; Gadjah Mada
   University; Gadjah Mada University; Central General Hospital Dr.
   Sardjito; Gadjah Mada University; Central General Hospital Dr. Sardjito;
   Gadjah Mada University
RP Seswandhana, MR (通讯作者)，Univ Gadjah Mada, Dr Sardjito Hosp, Plast Reconstruct & Aesthet Surg Div, Fac Med Publ Hlth & Nursing,Dept Surg, Jl Kesehatan 1, Yogyakarta 55281, Indonesia.
EM rosadi_seswandhana@ugm.ac.id; drgunadi@ugm.aca; irianiwati@ugm.ac.id;
   yohanes.widodo@ugm.ac.id
RI Seswandhana, Rosadi/AAH-4064-2020
FU Academic Excellence Grant from Universitas Gadjah Mada [7725/UN1,
   P.II/Dit-Lit/PT.01.03/2023]
FX This research was funded by Academic Excellence Grant from Universitas
   Gadjah Mada (7725/UN1.P.II/Dit-Lit/PT.01.03/2023) .
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAR
PY 2026
VL 114
BP 58
EP 70
DI 10.1016/j.bjps.2025.12.034
EA JAN 2026
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CX9NT
UT WOS:001677069400001
PM 41570608
DA 2026-07-24
ER
PT J
AU Cheong, DCF
   Chen, CF
   Kuo, WL
   Huang, JJ
AF Cheong, David C. -F.
   Chen, Chia-Fang
   Kuo, Wen-Ling
   Huang, Jung-Ju
TI Profunda Artery Perforator Flap for Autologous Breast Reconstruction: A
   Review of the Evidence and the Linkou Chang Gung Memorial Hospital
   Experience
SO SEMINARS IN PLASTIC SURGERY
LA English
DT Review
DE autologous breast reconstruction; profunda artery perforator flap; PAP
   flap; low-body mass index; patient-reported outcomes; BREAST-Q
ID PAP FLAP; TECHNICAL REFINEMENTS; OUTCOMES
AB This study aimed to summarize and highlight institutional experience on the profunda artery perforator (PAP) flap for autologous breast reconstruction. Contemporary series demonstrate high flap success and patient satisfaction with PAP reconstruction. Key technical evolutions include perforator-targeted skin paddle designs, strategies to augment venous outflow when needed, and standardized donor site management. Comparative studies and systematic reviews suggest reconstructive reliability comparable to other autologous options, while donor site wound morbidity remains the main area for optimization. In the low-body mass index (BMI) Asian cohort, PAP reconstruction achieved high success, and closed-incision negative pressure wound therapy (iNPWT) reduced donor site wound complications. The PAP flap is a versatile alternative when the abdomen is unsuitable, particularly for small-to-moderate volume breast reconstruction. Outcomes are optimized by careful patient selection, perforator mapping, thoughtful flap design, proactive venous outflow planning, and meticulous donor site closure. Stacked/Bilateral PAP strategies and staged fat grafting expand indications when a single flap is unlikely to meet volume requirements.
C1 [Cheong, David C. -F.; Chen, Chia-Fang; Huang, Jung-Ju] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Plast & Reconstruct Surg, Div Reconstruct Microsurg, Taoyuan, Taiwan.
   [Cheong, David C. -F.; Chen, Chia-Fang; Kuo, Wen-Ling; Huang, Jung-Ju] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
   [Cheong, David C. -F.; Chen, Chia-Fang; Kuo, Wen-Ling; Huang, Jung-Ju] Chang Gung Mem Hosp, Breast Canc Ctr, Linkou Med Ctr, Taoyuan, Taiwan.
   [Kuo, Wen-Ling] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Gen Surg, Taoyuan, Taiwan.
   [Kuo, Wen-Ling] Natl Tsing Hua Univ, Sch Med, Hsinchu, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; National Tsing Hua University
RP Huang, JJ (通讯作者)，Chang Gung Mem Hosp, Linkou Med Ctr, Dept Plast & Reconstruct Surg, 5 Fuxing St, Taoyuan City 33305, Taiwan.
EM jungjuhuang@gmail.com
RI Cheong, David/LQK-7335-2024
CR Artz JD, 2022, J RECONSTR MICROSURG, V38, P284, DOI 10.1055/s-0041-1731764
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   Haddock NT, 2012, MICROSURG, V32, P507, DOI 10.1002/micr.21980
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   Lee ZH, 2022, PRS-GLOB OPEN, V10, DOI 10.1097/GOX.0000000000004215
   Matsumine H, 2025, PRS-GLOB OPEN, V13, DOI [10.1097/gox.0000000000006933, 10.1097/GOX.0000000000006933]
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   Tanaka N, 2024, PRS-GLOB OPEN, V12, DOI 10.1097/GOX.0000000000006129
   Tielemans HJP, 2021, J PLAST RECONSTR AES, V74, P300, DOI 10.1016/j.bjps.2020.08.109
   Varnava C, 2024, MICROSURG, V44, DOI 10.1002/micr.31179
   Varnava C, 2023, J PLAST RECONSTR AES, V80, P168, DOI 10.1016/j.bjps.2023.02.018
   Wong AWJ, 2025, MICROSURG, V45, DOI 10.1002/micr.70009
   Wong C, 2015, PLAST RECONSTR SURG, V136, P915, DOI [10.1097/prs.0000000000001713, 10.1097/PRS.0000000000001713]
NR 29
TC 0
Z9 0
U1 1
U2 1
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1535-2188
EI 1536-0067
J9 SEMIN PLAST SURG
JI Semin. Plast. Surg.
PD FEB
PY 2026
VL 40
IS 01
BP 78
EP 82
DI 10.1055/a-2781-5836
EA FEB 2026
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GZ1OW
UT WOS:001677634200001
PM 42037621
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Li, Y
   Li, W
   Dou, LR
   Ding, HZ
AF Li, Yang
   Li, Wei
   Dou, Lianrong
   Ding, Hongzhi
TI Morel-Lavallée lesion: A case report and literature review
SO MEDICINE
LA English
DT Article
DE closed degloving injury; Morel-Lavall & eacute;e lesion; sarcoma; soft
   tissue; trauma
ID MOREL-LAVALLEE LESIONS; DEGLOVING INJURIES; MANAGEMENT; DIAGNOSIS;
   THIGH; KNEE
AB Rationale:Morel-Lavall & eacute;e lesions (MLLs) represent closed degloving injuries resulting from traumatic separation of skin/subcutaneous tissue from deep fascia. While typically associated with high-energy trauma, diagnosis becomes challenging in cases with occult trauma, complex comorbidities, or tumor-mimicking imaging features. This case report aims to highlight the diagnostic challenges and management strategy of MLL in a patient with a history of malignancy and anticoagulant therapy, underscoring the importance of pathological confirmation in atypical presentations.Patient concerns:A 56-year-old woman was diagnosed with: MLL, hypertension, type II diabetes mellitus, status post meningioma resection, status post hysterectomy for cervical cancer, and status post inferior vena cava filter placement. Hip magnetic resonance imaging revealed soft tissue infiltration. Following comprehensive history review and pathological evaluation, malignancy was excluded, confirming the diagnosis of MLL.Diagnoses:Morel-Lavall & eacute;e lesion.Interventions:Initial management included intravenous antibiotic therapy (cefazolin, 1 g twice daily) and percutaneous aspiration of fluid for pathological examination. Following exclusion of malignancy, the patient underwent debridement of peritrochanteric soft tissues with subsequent application of vacuum sealing drainage.Outcomes:The patient showed significant clinical improvement following percutaneous aspiration and antibiotic therapy. After surgical debridement and vacuum sealing drainage application, the wound healed completely without recurrence. She was discharged after an additional week of postoperative antibiotics and supportive care, with no complications at 1-month follow-up.Lessons:MLL require differential diagnosis from soft tissue neoplasms, particularly in patients with a history of malignancy. Anticoagulation may predispose to occult MLL development. Consequently, pathological examination is essential to establish a definitive diagnosis of MLL.
C1 [Li, Yang; Li, Wei; Dou, Lianrong; Ding, Hongzhi] Shanghai Jiao Tong Univ, Songjiang Hosp, Sch Med, Dept Orthopaed Surg, 746 Zhongshan Middle Rd, Shanghai 201600, Peoples R China.
C3 Shanghai Jiao Tong University
RP Ding, HZ (通讯作者)，Shanghai Jiao Tong Univ, Songjiang Hosp, Sch Med, Dept Orthopaed Surg, 746 Zhongshan Middle Rd, Shanghai 201600, Peoples R China.
EM fishbone@vip.sina.com; fishbone@vip.sina.com; dd_dlr@sina.com;
   dinghongzhi121314@163.com
CR Amaravathi U, 2023, J EMERG MED, V64, P67, DOI 10.1016/j.jemermed.2022.10.012
   Arunesh G., 2021, BMJ Case Rep, V14, pe244441
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   Yang Y, 2023, ORTHOP SURG, V15, P2485, DOI 10.1111/os.13826
NR 38
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN 16
PY 2026
VL 105
IS 3
AR e47083
DI 10.1097/MD.0000000000047083
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC1LJ
UT WOS:001679911700003
PM 41560018
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Liu, BY
   Liu, JJ
   Ren, YR
   Xiang, JJ
   Xiao, BL
   Sun, YM
AF Liu, Bingyan
   Liu, Junjun
   Ren, Yanrui
   Xiang, Jinjian
   Xiao, Baolai
   Sun, Yimin
TI Clinical application of a custom-made simple subcutaneous negative
   pressure drainage device for the treatment of SSI after abdominal
   surgery: a randomized controlled trial
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE abdominal surgery; randomized controlled trial; surgical site infection;
   vacuum sealing drainage
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; THERAPY; PREVENTION
AB Background:The current gold standard for managing surgical site infections (SSIs) is the vacuum-assisted closure (VAC) technique, also known as vacuum sealing drainage (VSD). However, its high cost and technical complexity necessitate specialized health care personnel for proper application and monitoring, thereby limiting its widespread clinical adoption. Building on the theoretical framework and mechanistic principles of VSD systems, we developed a simplified subcutaneous negative pressure drainage device and conducted a preliminary evaluation of its clinical efficacy and potential for broader implementation. Objective:To evaluate the clinical efficacy of a novel, custom-designed simplified subcutaneous negative pressure drainage device for the treatment of SSIs following abdominal surgery. Methods:A total of 85 patients who were diagnosed with postoperative incisional infections following abdominal surgery between August 2022 and November 2024 were enrolled as study participants. These patients were randomly allocated using a computer-generated randomization sequence into either a standard care group or an intervention group. The standard care group received standard wound care, including conventional dressing changes, whereas the intervention group was treated with a custom-designed simplified subcutaneous negative pressure drainage device. The primary endpoint was wound healing status. The secondary endpoints included the wound healing time, frequency of dressing changes, cost of wound care, duration of antibiotic therapy, length of hospital stay, serum C-reactive protein (CRP) and interleukin-6 (IL-6) levels, and patient satisfaction scores.Results:Compared with the standard care group, the intervention group demonstrated superior wound healing outcomes (P < 0.001). Furthermore, the intervention group demonstrated significantly shorter wound healing times, fewer dressing changes, lower wound care costs, a shorter duration of antibiotic use, and shorter hospital stays than did the standard care group (all P < 0.001). Posttreatment CRP and IL-6 levels were significantly lower in both groups (P < 0.001). Patient satisfaction scores were also significantly higher in the intervention group than in the standard care group (P < 0.001). Conclusion:The custom-designed, simple subcutaneous negative pressure drainage device effectively improves the healing of infected wounds after abdominal surgery. It shortens the duration of antibiotic therapy and hospital stay while reducing overall treatment costs. This device demonstrates satisfactory therapeutic efficacy and holds strong potential for widespread clinical application and promotion.
C1 [Liu, Bingyan; Liu, Junjun; Ren, Yanrui] Yangtze Univ, Affiliated Hosp 1, Dept Nursing, Jingzhou, Peoples R China.
   [Xiang, Jinjian; Xiao, Baolai; Sun, Yimin] Yangtze Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, 8 Hangkong Rd, Jingzhou 434000, Hubei, Peoples R China.
C3 Yangtze University; Yangtze University
RP Sun, YM (通讯作者)，Yangtze Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, 8 Hangkong Rd, Jingzhou 434000, Hubei, Peoples R China.
EM bingyan189@163.com; 1524240872@qq.com; 709064048@qq.com;
   freeskyxiang@126.com; 414132346@qq.com; sunyimin545589834@163.com
FU Guiding Project of Jingzhou Science and Technology Program [2024HD91];
   Jingzhou Joint Scientific Research Fund Project [2024LHY19]
FX This research was funded by the Guiding Project of Jingzhou Science and
   Technology Program (Grant No. 2024HD91) and the Jingzhou Joint
   Scientific Research Fund Project (Grant No. ).
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NR 24
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD JAN
PY 2026
VL 112
IS 1
BP 990
EP 998
DI 10.1097/JS9.0000000000003504
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DC9PK
UT WOS:001680465700025
PM 41056051
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Yan, XL
   Fu, XK
   Li, WR
AF Yan, Xiaoling
   Fu, Xiaokui
   Li, Weiren
TI Giant sinus tract formation following percutaneous renal biopsy in a
   patient with systemic lupus erythematosus: A case report
SO MEDICINE
LA English
DT Article
DE case report; giant sinus tract; magnetic resonance imaging; percutaneous
   renal biopsy; systemic lupus erythematosus
ID THERAPY
AB Rationale:Although percutaneous renal biopsy is generally considered safe, it can result in complications such as sinus tract formation, particularly in immunocompromised patients. In systemic lupus erythematosus (SLE), prolonged immunosuppression impairs tissue repair, complicating management. No standardized treatment exists for post-biopsy sinus tracts in SLE, and conventional approaches often yield poor results. A case of a giant sinus tract after renal biopsy in an SLE patient, successfully managed with multidisciplinary therapy, offering a potential reference for similar complex cases.Patient concerns:A 38-year-old woman with an 8-year history of SLE and lupus nephritis was admitted due to persistent redness and exudation at the renal biopsy site for 5 months. Prior treatments at an outside hospital, including intravenous antibiotics, abscess incision and drainage, and routine dressing changes, were ineffective, and her symptoms progressively worsened. Imaging revealed an irregular sinus tract measuring approximately 10 cm x 9 cm in the right lumbar region.Diagnoses:Giant sinus tract formation following percutaneous renal biopsy.Interventions:Standard immunosuppressive therapy was initiated to control SLE. On day 5, the patient underwent debridement combined with negative pressure wound therapy with instillation using hydrogen peroxide. Medications were adjusted with the support of the nephrology department. On day 13, radical excision of the sinus tract, further debridement, and skin flap grafting were performed. Dual-mode negative pressure drainage was applied to accelerate healing, and systemic antibiotics were administered based on culture and sensitivity results.Outcomes:By day 40 of hospitalization, the wound was completely epithelialized, without redness or discharge. The patient achieved complete clinical healing and remained recurrence-free during a 4-year follow-up.Lessons:Despite the relatively low post-procedural infection rate in SLE patients, clinicians should remain vigilant for complications such as sinus tract formation at the biopsy site. Early imaging is essential for timely diagnosis and preventing missed diagnoses. In this case, a combination of immunomodulation, negative pressure wound instillation therapy, and local skin flap reconstruction, along with dual-mode negative pressure drainage, demonstrated high debridement efficiency, minimal trauma, improved healing, better prognosis, and a low recurrence rate.
C1 [Yan, Xiaoling] Guizhou Prov Peoples Hosp, Dept Burn & Plast Surg, Guiyang, Peoples R China.
   [Fu, Xiaokui] Guizhou Med Univ, Affiliated Hosp, Dept Anesthesiol, Guiyang, Peoples R China.
   [Li, Weiren] Guizhou Med Univ, Affiliated Hosp, Dept Burn & Plast Surg, 28 Guiyi St, Guiyang 550001, Peoples R China.
C3 Guizhou Medical University; Guizhou Medical University
RP Li, WR (通讯作者)，Guizhou Med Univ, Affiliated Hosp, Dept Burn & Plast Surg, 28 Guiyi St, Guiyang 550001, Peoples R China.
EM 297357131@qq.com; 809233655@qq.com; hn_yxl0722@163.com
OI 颜, 小玲/0009-0009-3046-626X
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NR 35
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN 9
PY 2026
VL 105
IS 2
AR e46780
DI 10.1097/MD.0000000000046780
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC9YX
UT WOS:001680490400017
PM 41517776
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rao, D
   Kumar, P
   Prabhu, V
AF Rao, Devika
   Kumar, Praveen
   Prabhu, Vijendra
TI Advancements in seawater immersion wound management: Current treatments
   and innovations
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE blast injury; microbial infection; seawater immersion wound; soft tissue
   infections; wound management
ID VACUUM-ASSISTED CLOSURE; SKIN; INJURY
AB With advancements in naval warfare, the number and severity of seawater injuries have skyrocketed, necessitating effective seawater immersion (SWI) wound management. The unique marine pathogens, salinity, low temperature and alkalinity of seawater are the main environmental factors that can influence SWI wound healing. The current treatment strategy for SWI wounds follows a standard protocol based on terrestrial wound conditions, neglecting seawater conditions. The key requirements for ideal SWI treatment include good adhesion to the wound surface to minimize further exposure to seawater, enhanced wound healing properties to minimize wound healing time and antibacterial properties to prevent infections from marine pathogens. Current SWI wound-specific treatments range from elaborate techniques like vacuum-sealed drainage and vacuum-assisted closure for severe blast injuries to simple application of hydrogels or collagen dressings for minor injuries. This review discusses the current status and development of various treatment modalities for SWI wounds. The development of these treatment strategies and an understanding of their mechanisms of action make us better prepared to manage and treat SWI injuries.
C1 [Rao, Devika; Kumar, Praveen; Prabhu, Vijendra] Manipal Acad Higher Educ, Manipal Inst Technol, Ctr Microfluid Biomarkers Photoceut & Sensors BioP, Dept Biotechnol,Photoceut & Regenerat Lab, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE)
RP Prabhu, V (通讯作者)，Manipal Acad Higher Educ, Manipal Inst Technol, Ctr Microfluid Biomarkers Photoceut & Sensors BioP, Dept Biotechnol,Photoceut & Regenerat Lab, Manipal 576104, Karnataka, India.
EM vijendra.prabhu@manipal.edu
RI Kumar, Praveen/P-7149-2015; Prabhu, Vijendra/F-7469-2014
OI Prabhu, Vijendra/0000-0001-5927-2180
FU Indian Council of Medical Research [5/4-5/Trauma/2020-NCD-1: 2020-5726]
FX Indian Council of Medical Research, Grant/Award Number:
   5/4-5/Trauma/2020-NCD-1: 2020-5726
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NR 32
TC 8
Z9 9
U1 10
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2024
VL 21
IS 10
AR e70070
DI 10.1111/iwj.70070
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DD1YD
UT WOS:001680623600001
PM 39353589
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhong, MF
   Guo, JW
   Qahar, M
   Huang, GT
   Wu, J
AF Zhong, Meifang
   Guo, Jiawei
   Qahar, Mulan
   Huang, Guangtao
   Wu, Jun
TI Combination therapy of negative pressure wound therapy and
   antibiotic-loaded bone cement for accelerating diabetic foot ulcer
   healing: A prospective randomised controlled trial
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE antibiotic-loaded bone cement; chronic foot ulcer; clinical therapy;
   negative pressure wound therapy; type 2 diabetes; wound bed preparation
ID LOWER-LIMB AMPUTATION; RISK; MACROPHAGES
AB Negative pressure wound therapy (NPWT) and antibiotic-loaded bone cement (ALBC) are commonly used treatments for diabetic foot ulcers (DFUs). However, the combined efficacy of these two modalities remains unclear. This clinical study aimed to assess the effectiveness and underlying mechanisms of NPWT&ALBC in the management of DFUs. A total of 28 patients were recruited, 16 of whom served as controls and received only NPWT, whilst 12 received NPWT&ALBC. Both groups underwent wound repair surgery following the treatments. Blood samples were obtained to detect infections and inflammation. Wound tissue samples were also collected before and after the intervention to observe changes in inflammation, vascular structure and collagen through tissue staining. Compared with the NPWT group, the NPWT&ALBC group exhibited a superior wound bed, which was characterised by reduced inflammation infiltration and enhanced collagen expression. Immunostaining revealed a decrease in IL-6 levels and an increase in alpha-SMA, CD68, CD206 and collagen I expression. Western blot analysis demonstrated that NPWT&ALBC led to a decrease in inflammation levels and an increase in vascularization and collagen content. NPWT&ALBC therapy tends to form a wound bed with increased vascularization and M2 macrophage polarisation, which may contribute to DFUs wound healing.
C1 [Zhong, Meifang; Huang, Guangtao; Wu, Jun] Shenzhen Univ, Shenzhen Peoples Hosp 2, Hosp 1, Dept Burn & Plast Surg, Shenzhen 518028, Peoples R China.
   [Guo, Jiawei] Shenzhen Univ, Shenzhen Peoples Hosp 2, Hosp 1, Dept Hand & Foot Surg, Shenzhen, Peoples R China.
   [Guo, Jiawei] Shenzhen Univ, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasound, Natl Reg Key Technol Engn Lab Med Ultrasound,Med S, Shenzhen, Peoples R China.
   [Qahar, Mulan] Shenzhen Inst Translat Med, Shenzhen, Peoples R China.
C3 Shenzhen University; Shenzhen University; Shenzhen University
RP Huang, GT; Wu, J (通讯作者)，Shenzhen Univ, Shenzhen Peoples Hosp 2, Hosp 1, Dept Burn & Plast Surg, Shenzhen 518028, Peoples R China.
EM haitao3140@sina.com; junwupro@126.com
RI Guo, Jiawei/JMH-1084-2023
FU National Key Clinical Specialty ([2023] No. 25) [2000022]; The Project
   funded by China Postdoctoral Science Foundation [2023M742413]; Burns,
   Plastic Surgery, and Wound Repair, Guangtao Huang Scientific Research
   Startup Fund [4004050]; Shenzhen Science and Technology Program
   [JCYJ20230807115121043]
FX This work was supported by National Key Clinical Specialty ([2023] No.
   25) (2000022); Burns, Plastic Surgery, and Wound Repair, Guangtao Huang
   Scientific Research Startup Fund (4004050); the Project funded by China
   Postdoctoral Science Foundation (2023M7 42413) and Shenzhen Science and
   Technology Programme (JCYJ20230807115121043).
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NR 38
TC 14
Z9 21
U1 4
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2024
VL 21
IS 10
AR e70089
DI 10.1111/iwj.70089
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DD2ZD
UT WOS:001680693800001
PM 39379061
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Shi, ZY
   Li, XW
   Hou, SL
   Wang, BH
   Yang, R
AF Shi, Zeyao
   Li, Xiaowen
   Hou, Shulin
   Wang, Bihua
   Yang, Ru
TI Infectious Wound Healing After Surgical Resection of Giant
   Sacrococcygeal Teratoma in an Infant: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE infant; newborn; sacrococcygeal teratoma; wound healing
AB An infant diagnosed with sacrococcygeal teratoma was referred to the authors' hospital. On day 5 of admission, the infant underwent complete surgical resection of the tumor. Unfortunately, the wound was infected by Enterobacter cloacae and dehisced. Advanced dressings combined with vacuum sealing drainage were applied to facilitate wound healing. Eighteen days postsurgery, the wound showed good epithelialization, and the patient was discharged. The patient received regular dressing changes at a local hospital, and follow-up was conducted through telephone for 3 months. After 3 months, scar tissue formation was observed, and no complications were reported.
C1 [Shi, Zeyao; Li, Xiaowen; Hou, Shulin; Wang, Bihua; Yang, Ru] Sichuan Univ, West China Second Univ Hosp, Dept Neonatol, 20,Sect 3,South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China.
   [Shi, Zeyao; Li, Xiaowen; Hou, Shulin; Wang, Bihua; Yang, Ru] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Peoples R China.
C3 Sichuan University; Sichuan University
RP Li, XW (通讯作者)，Sichuan Univ, West China Second Univ Hosp, Dept Neonatol, 20,Sect 3,South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China.
EM zeyao-shi@scu.edu.cn; xiaowenli@scu.edu.cn; 1281984307@qq.com;
   1692235914@qq.com
OI Junco, Judy Von/0009-0003-5977-5249
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NR 22
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN-FEB
PY 2026
VL 39
IS 1
BP E62
EP E65
DI 10.1097/ASW.0000000000000365
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA DH2YQ
UT WOS:001683401400006
PM 40982754
DA 2026-07-24
ER
PT J
AU Gänzle, M
   Stöhr, M
   Dietz, A
AF Ganzle, Maximilian
   Stohr, Matthaus
   Dietz, Andreas
TI Difficult Wounds in the Head and Neck Area
SO LARYNGO-RHINO-OTOLOGIE
LA German
DT Article
DE NPWT; negative pressure wound therapy; wound healing; wound treatment;
   NPWT; negative pressure wound therapy; wound healing; wound treatment
ID COMPLICATIONS; EXPRESSION; CLOSURE; IMPACT; SKIN
AB Wound care in the head and neck region is particularly challenging due to its complex anatomy, functional significance, and aesthetic requirements. A careful approach that considers systemic and local factors, as well as consistent wound care, are crucial for healing with minimal complications. Traumatic, iatrogenic, and chronic wounds each require specific strategies, with wound closure, suture technique, and appropriate wound dressings significantly influencing success. Difficult wounds, such as those following bite injuries or complex postoperative defects, benefit from an interdisciplinary, individualized approach. This case report of a pharyngocutaneous fistula illustrates that conventional surgical procedures are not always sufficient. In addition, combined endo- and external NPWT can be a helpful option under certain conditions to promote granulation formation and support wound closure, although it is not yet standard practice. Future developments will be characterized by digital documentation, standardized follow-up, bioactive wound dressings, and regenerative procedures. The goal remains to shorten healing times, reduce complications, and optimize function and cosmetic outcomes. Overall, the article underscores the importance of an interdisciplinary and individualized approach that combines proven methods with innovative techniques to meet the complex requirements of complex wound care in the head and neck region.
C1 [Ganzle, Maximilian] Univ Klinikum Leipzig, Viszeral Transplant Thorax & Gefasschirurg, Leipzig, Germany.
   [Dietz, Andreas] Univ Klinikums Leipzig, HNO Klin, Leipzig, Germany.
C3 Leipzig University; Leipzig University
RP Gänzle, M (通讯作者)，Univ Klinikum Leipzig, Klin & Poliklin Hals Nasen & Ohrenheilkunde Plast, Liebigstr 12, D-04103 Leipzig, Germany.
EM Maximilian.Gaenzle@Medizin.Uni-Leipzig.de
OI Stoehr, Matthaeus/0000-0003-4219-4459
CR [Anonymous], 2012, Duale Reihe Chirurgie Stuttgart Thieme, V4
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NR 33
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0935-8943
EI 1438-8685
J9 LARYNGO RHINO OTOL
JI Laryngo-Rhino-Otol.
PD FEB
PY 2026
VL 105
IS 02
BP 113
EP 124
DI 10.1055/a-2623-3040
PG 12
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA DH6YZ
UT WOS:001683673700005
PM 41643652
DA 2026-07-24
ER
PT J
AU Yamashita, Y
   Abe, Y
   Bando, M
   Mima, S
   Yamasaki, H
   Nagasaka, S
   Mineda, K
   Hashimoto, I
AF Yamashita, Yutaro
   Abe, Yoshiro
   Bando, Mayu
   Mima, Shunsuke
   Yamasaki, Hiroyuki
   Nagasaka, Shinji
   Mineda, Kazuhide
   Hashimoto, Ichiro
TI Surgical methods for reducing early wound dehiscence after
   reconstruction surgery for pressure ulcer
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE decubitus ulcer; debridement; flap; incisional negative pressure wound
   therapy; pressure ulcer; surgical site infection; wound; wound care;
   wound dehiscence; wound dressing; wound healing
ID SITE INFECTION; RISK
AB Objective: Early postoperative wound dehiscence is the most common complication of pressure ulcers (PUs). The authors previously investigated the risk factors for this complication and reported that the main cause of early wound dehiscence was surgical site infection. This study aimed to improve the surgical method to decrease early postoperative wound dehiscence. Method: Patients with PUs between 2005 and 2022 were retrospectively investigated. In the control group, the ulcer surface was stained with methylene blue and debrided using the conventional method (surgical debridement). For comparison purposes, three test groups were established. In group 1, the ulcer surface was covered with hydrofibre with ionic silver, and debridement was performed using the covered debridement method. In group 2, debridement was performed using the conventional method and postoperative incisional negative pressure wound therapy (iNPWT) on the skin flap. Group 3 underwent both the covered debridement method and iNPWT. PatientV data on: sex; age; body mass index (BMI); history of diabetes; smoking history; PU site; detection of meticillin-resistant Staphylococcus aureus in wound bacterial culture; serum albumin level; operation time; and ulcer size, were collected. Significant differences from the control group were determined for each factor. Results: A total of 60 patients underwent flap coverage (control group: 39 patients; group 1: six patients; group 2: eight patients; group 3: seven patients). There were no significant differences between the groups for each item except for albumin level and BMI. Rates of early wound dehiscence in the control group and groups 1, 2 and 3 were 15/39 (38.5%); 2/6 (33.3%; p=0.81); 2/8 (25%; p=0.47), and 0/7 (0.0%; p=0.049), respectively. Conclusion: A combination of methods may effectively reduce the incidence of early wound dehiscence. Declaration of interest: The authors have no conflicts of interest to declare.
C1 [Yamashita, Yutaro; Abe, Yoshiro; Bando, Mayu; Mima, Shunsuke; Yamasaki, Hiroyuki; Nagasaka, Shinji; Mineda, Kazuhide; Hashimoto, Ichiro] Tokushima Univ, Dept Plast & Reconstruct Surg, 2-50-1 Kuramoto-Cho, Tokushima, Tokushima 7708503, Japan.
C3 Tokushima University
RP Yamashita, Y (通讯作者)，Tokushima Univ, Dept Plast & Reconstruct Surg, 2-50-1 Kuramoto-Cho, Tokushima, Tokushima 7708503, Japan.
EM thestarstripjp@yahoo.co.jp
RI /AFK-5986-2022
CR [Anonymous], 2016, GLOBAL GUIDELINES PR
   Bamba R, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001187
   Cheng H, 2017, SURG INFECT, V18, P722, DOI 10.1089/sur.2017.089
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NR 19
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2026
VL 35
IS 2
SU A
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DL1UE
UT WOS:001686041500001
DA 2026-07-24
ER
PT J
AU Beele, H
   Gomes, CF
   Vieira, N
   Castro, J
   Alves, P
AF Beele, Hilde
   Gomes, Carlos Filipe
   Vieira, Nuna
   Castro, Joao
   Alves, Paulo
TI Dynamic management of pressure injuries using a portable canister-based
   single-use negative pressure wound therapy device
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE low-to-moderate exuding wounds; exudate management; pressure injuries;
   single-use negative pressure wound therapy system; wound dressing; wound
   circle; wound care; wound healing
ID VACUUM-ASSISTED CLOSURE; EVIDENCE-BASED RECOMMENDATIONS; CARE;
   MULTICENTER; STEPS; MMP-8
AB Objective: Negative pressure wound therapy (NPWT) helps to reduce tissue deficits by removing excess fluid, promoting granulation tissue formation and stabilising the wound environment. This prospective, open, non-comparative clinical study assessed these factors using a canister-based single-use NPWT (CB-suNPWT) system for the management of low-to-moderate exuding pressure injuries (PIs). Method: This 28-day multicentre investigation assessed wound progress compared with the previous visit at which the CB-suNPWT system was applied and also from baseline to study completion. Additional endpoints included: changes in wound area and volume; tissue type; exudation (amount, nature and odour); periwound skin condition; pain levels at dressing removal; tissue ingrowth into foam; system wear time; product consumption; and therapy adherence. Adverse events (AEs) were also recorded. Results: The study recruited 35 patients with PIs at four sites in Portugal. All were included in the full analysis group. Statistically significant wound progress was observed, with 80.6% of cases showing improvement compared with the previous visit (95% confidence interval: 72.7, 80.6; p<0.05). Improvements in wound tissue and exudate levels, type and odour were also observed, and a marked increase in granulation tissue reported, combined with reductions in wound size and volume. Tissue ingrowth into the foam was reported in only two (0.57%) dressing changes. The device was well received by both investigators and patients, easy to use and managed exudate levels effectively. A minimal number of AEs were reported. Conclusion: In this study, the CB-suNPWT device promoted improvements in the wound bed, resulting in progression towards healing of low-to-moderate exuding PIs. Declaration of interest: This study was sponsored by M & ouml;lnlycke Health Care, M & ouml;lndal, Sweden. The authors have no conflicts of interest to declare.
C1 [Beele, Hilde] Ghent Univ Hosp, Dept Dermatol, Ghent, Belgium.
   [Beele, Hilde] Ghent Univ Hosp, Wound Care Ctr, Ghent, Belgium.
   [Gomes, Carlos Filipe] Complexo Social Moita Rua Misericordia, Aveiro, Portugal.
   [Vieira, Nuna] Unidade Cuidados Continuados Antonio Francisco Gui, Vizela, Portugal.
   [Castro, Joao] Wecare Saude Unidade Cuidados Continuados & Paliat, Povoa De Varzim, Portugal.
   [Alves, Paulo] Catholic Univ Portugal, Ctr Interdisciplinary Res Hlth CIIS, P-3504505 Viseu, Portugal.
   [Alves, Paulo] Trofa Saude Hosp Cent Hosp Trofa, Vila Do Conde, Portugal.
C3 Ghent University; Ghent University Hospital; Ghent University; Ghent
   University Hospital; Universidade Catolica Portuguesa
RP Beele, H (通讯作者)，Ghent Univ Hosp, Dept Dermatol, Ghent, Belgium.
EM Hilde.Beele@uzgent.be
RI Alves, Paulo/AAD-1391-2019
OI Alves, Paulo/0000-0002-6348-3316
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 34
TC 0
Z9 0
U1 1
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2026
VL 35
IS 2
BP 125
EP 136
DI 10.12968/jowc.2025.0541
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DM3EM
UT WOS:001686817700001
PM 41649921
DA 2026-07-24
ER
PT J
AU Muthu, S
   Viswanathan, VK
   Munisamy, S
   Ponnusamy, DVK
   Theiss, S
   Chandra, SKR
   Sharun, K
   Manoharan, SRR
AF Muthu, Sathish
   Viswanathan, Vibhu Krishnan
   Munisamy, Sathish
   Kolarpatti Ponnusamy, Dhibin Vikash
   Theiss, Steven
   Rajappan Chandra, Sathish Kumar
   Sharun, Khan
   Rajaram Manoharan, Sakthivel Rajan
TI Role of Prophylactic Negative Pressure Wound Therapy in Reducing
   Surgical-Site Infections in Spine Surgery - A Systematic Review and
   Meta-Analysis
SO GLOBAL SPINE JOURNAL
LA English
DT Review; Early Access
DE spine surgery; negative pressure wound therapy; surgical site infection;
   wound complications; prophylactic VAC; cost effectiveness
ID VACUUM-ASSISTED CLOSURE; GUIDELINE; FUSION; DEHISCENCE; PREVENTION;
   MANAGEMENT; RISK
AB Study Design Systematic Review and Meta-analysis. Objective To evaluate the prophylactic efficacy of incisional negative pressure wound therapy(NPWT) in mitigating the postoperative complications following primary spine surgery. Methods A comprehensive search of the databases (PubMed, Embase, Scopus and Web of Science) was performed until October 2025 since inception. Studies comparing incisional NPWT vs standard wound dressing after primary spine surgery were included if at least one of the relevant outcome measures was reported. While the primary endpoint was surgical site infection(SSI), the evaluated secondary outcomes included wound complications, reoperations, readmissions, length of hospital stay(LOS), and cost-effectiveness. Random-effects meta-analysis with Knapp-Hartung adjustment was employed to calculate pooled odds ratios(ORs) and mean differences(MD). The risk of bias assessment was made using the Cochrane ROB2 tool and Newcastle Ottawa Scale. Results Thirteen studies comprising 7619 patients(851NPWT and 6,768controls) were analysed. NPWT significantly mitigated the SSI rates[OR = 0.42, 95%CI(0.28-0.63)P < 0.001;I-2 = 78%) and wound complications[OR = 0.51,95%CI(0.33-0.78)P = 0.03;P = 0.03;I-2 = 0%]. In contrast, reoperation rates[OR = 0.68,95%CI(0.39-1.18)], readmissions[OR = 0.76,95%CI(0.45-1.29)], and LOS [MD = -1.05days,95%CI(-2.16,0.07)] demonstrated non-significant trends, indicating the clinical implications of these secondary outcomes remain uncertain. Two studies reported marked cost savings, with up to $12.9 saved for per $1 spent on NPWT. No significant publication bias was observed. Conclusion Prophylactic incisional NPWT is associated with reduced SSI and wound complications in spine surgery. Given the predominance of retrospective studies, protocol heterogeneity, and limited cost-effectiveness data, these findings should be interpreted cautiously. Current evidence suggests NPWT may be most beneficial in selected high-risk patients, with larger multicentric RCTs needed to confirm routine use and economic value.
C1 [Muthu, Sathish; Viswanathan, Vibhu Krishnan] Dept Spine Surg, Orthopaed Res Grp, Coimbatore 641045, Tamil Nadu, India.
   [Muthu, Sathish] Meenakshi Acad Higher Educ & Res, Meenakshi Med Coll Hosp & Res Inst, Cent Res Lab, Chennai, India.
   [Viswanathan, Vibhu Krishnan; Theiss, Steven; Rajaram Manoharan, Sakthivel Rajan] Univ Alabama Birmingham, Dept Orthoped Surg, Birmingham, AL USA.
   [Munisamy, Sathish] Govt Med Coll, Dept Orthopaed, Namakkal, Tamil Nadu, India.
   [Kolarpatti Ponnusamy, Dhibin Vikash] Govt Med Coll, Dept Orthopaed, Karur, Tamil Nadu, India.
   [Rajappan Chandra, Sathish Kumar] SRM Inst Sci & Technol, Interdisciplinary Inst Indian Syst Med, Clin Trial & Res Unit, Kattankulathur, India.
   [Sharun, Khan] Yuan Ze Univ, Grad Inst Med, Taoyuan, Taiwan.
C3 Meenakshi Academy of Higher Education & Research (MAHER); Meenakshi
   Medical College Hospital & Research Institute; University of Alabama
   System; University of Alabama Birmingham; SRM Institute of Science &
   Technology Chennai; Yuan Ze University
RP Muthu, S (通讯作者)，Dept Spine Surg, Orthopaed Res Grp, Coimbatore 641045, Tamil Nadu, India.
EM drsathishmuthu@gmail.com
RI Muthu, Sathish/G-5756-2018; Sharun, Khan/A-3084-2019; Viswanathan,
   Vibhu/Q-1461-2017
OI Muthu, Sathish/0000-0002-7143-4354; Munisamy,
   Sathish/0009-0009-3417-7772; Sharun, Khan/0000-0003-1040-3746; K P,
   DHIBIN VIKASH/0000-0003-1071-0084
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NR 51
TC 2
Z9 3
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2192-5682
EI 2192-5690
J9 GLOB SPINE J
JI Glob. Spine J.
PD 2026 FEB 11
PY 2026
DI 10.1177/21925682261426264
EA FEB 2026
PG 18
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA DN0KL
UT WOS:001687308800001
PM 41670395
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Oh, KS
   Cho, W
   Kim, J
   Kim, KN
AF Oh, Kap Sung
   Cho, Wonseok
   Kim, Junekyu
   Kim, Kyu Nam
TI Clinical Salvage Approaches for Surgical Site Infection After Autologous
   Microtia Reconstruction
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE microtia; surgical wound infection; costal cartilage; negative-pressure
   wound therapy; reconstructive surgical procedures
ID AURICLE; MICROBIOLOGY; EPIDEMIOLOGY; FRAMEWORK
AB Background/Objectives: Surgical site infection (SSI) after autologous rib cartilage microtia reconstruction is an uncommon but potentially devastating complication, as infection of the avascular cartilage framework can rapidly lead to partial or complete framework loss. Traditional management often favored aggressive debridement or framework removal, resulting in significant deformity. This study aimed to evaluate salvage-oriented management strategies and to propose a structured treatment algorithm for SSI following microtia reconstruction. Methods: A retrospective case series was conducted of patients who developed SSI after autologous rib cartilage microtia reconstruction between March 2021 and November 2025. SSI was defined by clinical and surveillance criteria requiring intervention beyond routine postoperative care. Nine patients were included. Management strategies were analyzed with respect to infection control, framework preservation, and wound healing outcomes. Results: SSI occurred at variable time points, ranging from early postoperative infection to delayed and late-onset presentations. Identified pathogens included Gram-positive cocci and multidrug-resistant Gram-negative organisms. Negative-pressure wound therapy (NPWT) was applied in all cases with wound dehiscence, persistent drainage, or cartilage exposure. Conservative staged debridement was performed only after clear demarcation of nonviable tissue. Overall auricular framework preservation was achieved in 100% of patients, with no cases requiring complete framework removal, although limited cartilage loss occurred in select cases. These outcomes demonstrate the clinical feasibility and effectiveness of salvage-oriented management across heterogeneous infection scenarios. Conclusions: SSI following autologous microtia reconstruction can be effectively salvaged without routine framework removal through a structured, timing-based algorithm emphasizing early culture-guided antimicrobial therapy, NPWT, and conservative staged intervention. This salvage-oriented approach provides a clinically relevant and reproducible framework for preserving auricular structure while minimizing morbidity, even in infections involving multidrug-resistant organisms.
C1 [Oh, Kap Sung; Cho, Wonseok; Kim, Junekyu; Kim, Kyu Nam] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Plast & Reconstruct Surg, Seoul 03181, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Samsung Kangbuk
   Hospital
RP Kim, KN (通讯作者)，Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Plast & Reconstruct Surg, Seoul 03181, South Korea.
EM kapsung.oh@samsung.com; wscws26@naver.com; j7181.kim@samsung.com;
   manabear77@naver.com
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NR 28
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN 29
PY 2026
VL 15
IS 3
AR 1064
DI 10.3390/jcm15031064
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DN8PM
UT WOS:001687864300001
PM 41682743
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lindholm, VM
   Salminen, AW
   Koskenmies, SJ
   Salmivuori, MK
   Hannula-Jouppi, KSE
   Isoherranen, KM
AF Lindholm, Vivian Mikaela
   Salminen, Anna Wilhelmina
   Koskenmies, Sari Johanna
   Salmivuori, Mari Kaarina
   Hannula-Jouppi, Katariina Sara Eriikka
   Isoherranen, Kirsi Maria
TI An exploratory randomized clinical trial on negative pressure wound
   therapy for lower limb full-thickness skin grafts of dermatosurgical
   patients
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE compression therapy; full-thickness skin graft; negative pressure wound
   therapy; skin cancer
ID SURGICAL-SITE INFECTIONS; SURGERY; REPAIR
AB Full-thickness skin graft (FTSG) reconstructions of lower limbs are especially prone to wound complications. Negative pressure wound therapy (NPWT) enhances wound healing, but no broad evidence exists if it promotes graft take of lower leg FTSGs. In this investigator-initiated, prospective, randomised and controlled trial, 20 patients with ambulatory FTSG reconstruction for lower limb skin cancers were randomised for postoperative treatment with either NPWT, or conventional dressings. As outcomes, adherence of the skin graft 1 week postoperatively, any wound complications within 3 months, including >= 3 weeks delayed wound healing, and the number of additional postoperative visits were compared. In both groups, grafts adhered equally well (p = 0.47); 80% of NPWT-treated and 100% of control group grafts adhered >90%. There was no significant difference in the number of postoperative complications/delayed wound healing (p = 0.65); 70% of patients in the NPWT and 50% in the control group developed a wound complication. Both groups had an equal number of patients with at least three additional control visits (p = 1.0). The study was discontinued after 20 patients were recruited, as no benefit from NPWT was seen. To conclude, the study showed no benefit from NPWT for lower limb FTSGs.
C1 [Lindholm, Vivian Mikaela; Salminen, Anna Wilhelmina; Koskenmies, Sari Johanna; Salmivuori, Mari Kaarina; Hannula-Jouppi, Katariina Sara Eriikka; Isoherranen, Kirsi Maria] Univ Helsinki, ERN Skin Ctr, Dept Dermatol & Allergol, Helsinki, Finland.
   [Lindholm, Vivian Mikaela; Salminen, Anna Wilhelmina; Koskenmies, Sari Johanna; Salmivuori, Mari Kaarina; Hannula-Jouppi, Katariina Sara Eriikka; Isoherranen, Kirsi Maria] Helsinki Univ Hosp, Helsinki, Finland.
   [Hannula-Jouppi, Katariina Sara Eriikka] Folkhalsan Res Ctr, Helsinki, Finland.
   [Hannula-Jouppi, Katariina Sara Eriikka] Univ Helsinki, Stem Cells & Metab Res Program, Res Programs Unit, Helsinki, Finland.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital; Folkhalsan Research Center; University of Helsinki
RP Lindholm, VM (通讯作者)，HUS Iho jaallergiasairaala, Meilahdentie 2, Helsinki 00250, Finland.
EM vivian.lindholm@helsinki.fi
OI Salminen, Anna/0000-0002-4074-7956
FU Inflammation Center, Helsinki University Hospital; The Clinical Research
   Institute HUCH, Helsinki University Hospital
FX This non-sponsored investigator-initiated study was supported by the
   Clinical Research Institute Helsinki University Hospital (HUS) and HUS's
   Inflammation Center. The funders did not have any impact on study
   design, data collection, data analysis, manuscript preparation, or
   publication decisions.
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NR 24
TC 2
Z9 3
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2024
VL 21
IS 6
AR e14911
DI 10.1111/iwj.14911
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DS3FY
UT WOS:001690890200001
PM 38831721
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pérez-Acevedo, G
   Torra-Bou, JE
   Peiró-García, A
   Vilalta-Vidal, I
   Urrea-Ayala, M
   Bosch-Alcaraz, A
   Blanco-Blanco, J
AF Perez-Acevedo, Gemma
   Torra-Bou, Joan Enric
   Peiro-Garcia, Alejandro
   Vilalta-Vidal, Inmaculada
   Urrea-Ayala, Mireia
   Bosch-Alcaraz, Alejandro
   Blanco-Blanco, Joan
TI Incisional negative pressure wound therapy for the prevention of
   surgical site complications in Paediatric patients with non-idiopathic
   scoliosis: A randomized clinical trial
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure wound therapy; paediatrics; prevention; spine surgery;
   surgical wound complications
ID SPINAL-FUSION; RISK-FACTORS; INFECTION; VACUUM; MULTICENTER; CHILDREN;
   CLOSURE
AB Surgical wound complications are adverse events with important repercussions for the health of patients and health system. Surgical site infections and wound dehiscences are among the most important surgical wound complications, with a high incidence in paediatric patients undergoing surgery for non-idiopathic scoliosis. Incisional negative pressure wound therapy for surgical incisions is used as a preventive measure against surgical wound complications in adults; however, there has been scant evidence for using it in children. The purpose of this study is to evaluate the cost-effectiveness of incisional negative pressure wound therapy in preventing surgical wound complications in paediatric patients undergoing surgery to treat non-idiopathic scoliosis. Randomized clinical trial. Children younger than 18 years of age undergoing surgery for non-idiopathic scoliosis were randomly assigned into two groups to receive one of two different types of dressings for the first 7 days after surgery. One group were treated with a postoperative hydrofibre and hydrocolloid dressing with silver for wounds (control group), and the other group received a single-use incisional negative pressure wound therapy system (intervention group). The wounds were assessed after removal of the dressings at 7 days after surgery and again at 30, 90, and 180 days after surgery. Surgical wound complications, sociodemographic variables, variables related to the procedure and postoperative period, economic costs of treatment of surgical wound complications, and time to healing of the surgical wound were recorded. Per protocol and per intention to treat analysis was made. The per protocol incidence of surgical wound complications was 7.7% in the intervention group versus 38.5% in the control group (p = 0.009; Fisher exact test. RR = 0.20 IC95%: 0.05-0.83). Surgical wound dehiscence, surgical site infections, seroma, and fibrin were the most common surgical wound complications. The type of surgery, duration of surgery, and patients' age were associated with a higher risk for surgical wound complications. Postoperative hydrofibre and hydrocolloid dressing with silver for wounds were found to be associated with a longer time to healing. Initial costs for dressings in the group receiving incisional negative pressure wound therapy were higher, but the total postoperative costs were higher for those receiving postoperative hydrofibre and hydrocolloid dressing with silver for wounds. It was found that for each US$1.00 of extra costs for using incisional negative pressure wound therapy, there was a benefit of US$12.93 in relation to the cost of complications prevented. Incisional negative pressure wound therapy is cost-effective in the prevention of surgical wound complications in children undergoing surgery for non-idiopathic scoliosis.
C1 [Perez-Acevedo, Gemma] Sant Joan Deu Hosp, Doctoral candidate Hlth & Adv practice nurse Pedia, Barcelona, Spain.
   [Torra-Bou, Joan Enric] Univ Lleida, Fac Nursing & Physiotherapy, Doctoral Program, GESEC, Barcelona, Spain.
   [Torra-Bou, Joan Enric] Inst Res & Innovat Life & Hlth Sci Cent Catalonia, Tissue Repair & Regenerat Lab Res Grp Tr2Lab, GRECS, IRBLleid, Barcelona, Spain.
   [Peiro-Garcia, Alejandro; Vilalta-Vidal, Inmaculada] Hosp San Juan Dios, Un Columna, Barcelona, Spain.
   [Urrea-Ayala, Mireia] Sant Joan Deu Hosp, Clin Safety Program, Barcelona, Spain.
   [Bosch-Alcaraz, Alejandro] Univ Barcelona, Fac Nursing, Dept Publ Hlth Mental Hlth & Maternal & Child Hlth, Barcelona, Spain.
   [Blanco-Blanco, Joan] Univ Lleida, Fac Nursing & Physiotherapy, GESEC, Lleida, Spain.
   [Blanco-Blanco, Joan] Univ Lleida, GRECS, IRBLleida Res Grp, Lleida, Spain.
   [Blanco-Blanco, Joan] Inst Res & Innovat, CIBERFES Biomed Res Ctr Red, Madrid, Spain.
C3 Universitat de Lleida; University of Barcelona; University of Barcelona;
   Universitat de Lleida; Universitat de Lleida
RP Pérez-Acevedo, G (通讯作者)，Sant Joan Deu Hosp, Doctoral candidate Hlth & Adv practice nurse Pedia, Barcelona, Spain.; Torra-Bou, JE (通讯作者)，Univ Lleida, Fac Nursing & Physiotherapy, Doctoral Program, GESEC, Barcelona, Spain.; Pérez-Acevedo, G (通讯作者)，Doctoral candidate Hlth & Adv practice nurse Pedia, 16-20 Roseta Canalias St, Barcelona 08750, Spain.; Torra-Bou, JE (通讯作者)，Univ Lleida, Fac Nursing & Physiotherapy, GESEC, 5 Bis Galla St, Barcelona 08031, Spain.
EM gemma.perez@sjd.es; jetorrabou@hotmail.com
RI Bosch Alcaraz, Alejandro/KDO-0418-2024; Blanco-Blanco, Joan/E-2813-2012
OI Bosch Alcaraz, Alejandro/0000-0001-6369-9697; 
FU Support was provided by a Catalonian Health Department research grant
   [PERIS 2017-2021- SLT017/20/000194]; unrestricted Smith Nephew grant
   [CCG00159]
FX Support was provided by a Catalonian Health Department research grant
   (PERIS 2017-2021- SLT017/20/000194) and an unrestricted Smith & Nephew
   grant (CCG00159).
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NR 37
TC 7
Z9 10
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP
PY 2024
VL 21
IS 9
AR e70034
DI 10.1111/iwj.70034
PG 17
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DS3IZ
UT WOS:001690898100001
PM 39224961
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU de la Fuente, PZ
   Suescún, FC
   Lázaro-Martínez, JL
   Herrera, RS
   Fernández, GP
AF de la Fuente, Patricia Zorrilla
   Suescun, Federico Castillo
   Lazaro-martinez, Jose Luis
   Sancibrian Herrera, Ramon
   Peralta Fernandez, Galo
TI New experimental model to evaluate the effect of negative pressure wound
   therapy and viscosity exudates in foam dressings using confocal
   microscopy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE exudates; negative pressure dressings; negative pressure wound therapy;
   wound healing; wounds
ID VACUUM-ASSISTED CLOSURE
AB Negative pressure wound therapy is currently one of the most popular treatment approaches that provide a series of benefits to facilitate healing, including increased local blood perfusion with reduced localized oedema and control of wound exudate. The porous foam dressing is a critical element in the application of this therapy and its choice is based on its ability to manage exudate. Industry standards often employ aqueous solutions devoid of proteins to assess dressing performance. However, such standardized tests fail to capture the intricate dynamics of real wounds, oversimplifying the evaluation process. This study aims to evaluate the technical characteristics of two different commercial polyurethane foam dressings during negative pressure wound therapy. We introduce an innovative experimental model designed to evaluate the effects of this therapy on foam dressings in the presence of viscous exudates. Our findings reveal a proportional increase in dressing fibre occupancy as pressure intensifies, leading to a reduction in dressing pore size. The tests underscore the pressure system's diminished efficacy in fluid extraction with increasing fluid viscosity. Our discussion points to the need of establishing standardized guidelines for foam dressing selection based on pore size and the necessity of incorporating real biological exudates into industrial standards.
C1 [de la Fuente, Patricia Zorrilla; Suescun, Federico Castillo; Peralta Fernandez, Galo] Inst Invest Sanitaria Valdecilla IDIVAL, Avda Cardenal Herrera Orias-N, Santander 39011, Spain.
   [de la Fuente, Patricia Zorrilla; Sancibrian Herrera, Ramon] Univ Cantabria, Santander, Spain.
   [Suescun, Federico Castillo] Hosp Univ Marques Valdecilla, Ave Valdecilla S-N, Santander, Spain.
   [Lazaro-martinez, Jose Luis] Univ Complutense Madrid, Fac Enfermeria Fisioterapia & Podol, Diabet Foot Unit, Clin Univ Podol, Madrid, Spain.
   [Lazaro-martinez, Jose Luis] Hosp Clin San Carlos, Inst Invest Sanitaria Hosp Clin San Carlos Madrid, Madrid, Spain.
C3 Hospital Universitario Marques de Valdecilla (HUMV); Universidad de
   Cantabria; Hospital Universitario Marques de Valdecilla (HUMV);
   Complutense University of Madrid; Hospital Clinico San Carlos
RP de la Fuente, PZ (通讯作者)，Inst Invest Sanitaria Valdecilla IDIVAL, Avda Cardenal Herrera Orias-N, Santander 39011, Spain.; de la Fuente, PZ (通讯作者)，Univ Cantabria, Santander, Spain.
EM zorrillafp@gmail.com
RI ; Sancibrian, Ramon/J-8369-2016; MARTINEZ, JOSE/AAE-2268-2021
OI Zorrilla, Patricia/0000-0002-8910-8469; 
FU Instituto de Investigacin Sanitaria Valdecilla (IDIVAL) [DTEC21/01]
FX This work has been made possible by a research grant (DTEC21/01) from
   Instituto de Investigacion Sanitaria Valdecilla (IDIVAL).
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 17
TC 1
Z9 1
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUL
PY 2024
VL 21
IS 7
AR e14964
DI 10.1111/iwj.14964
PG 15
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DS3NH
UT WOS:001690909300001
PM 38994863
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chen, SF
   Chang, CC
AF Chen, Shiuan-Fu
   Chang, Chang-Cheng
TI Case Report: Negative pressure wound therapy with instillation and dwell
   time as adjuvant therapy for limb salvage in a complicated necrotizing
   fasciitis on ischemic diabetic foot
SO FRONTIERS IN SURGERY
LA English
DT Article
DE dermal substitute; diabetic foot ulcer; limb salvage; multidisciplinary
   management; multimodal therapy; necrotizing fasciitis; negative-pressure
   wound therapy with instillation and dwell time; negative-pressure wound
   therapy
ID DERMAL MATRIX; MANAGEMENT; DETERMINANTS; MORTALITY; ULCERS; SKIN
AB Background Necrotizing fasciitis superimposed on ischemic diabetic foot ulcers represents a complex and limb-threatening condition, especially in patients with multiple comorbidities such as end-stage renal disease, peripheral arterial occlusive disease, and poorly controlled diabetes mellitus. Optimal wound management strategies that minimize surgical burden while enhancing infection control and tissue regeneration are essential. This case highlights the use of multimodal adjuvant therapies and multidisciplinary management for limb salvage in a high-risk patient.Case presentation A 60-year-old woman with a Wagner grade 4 ischemic diabetic foot ulcer complicated by deep invasive necrotizing fasciitis underwent urgent extensive debridement, fasciotomy, and sequestrectomy, resulting in a large soft tissue defect with substantial bone and tendon exposure.Management A staged wound management approach was adopted, beginning with negative pressure wound therapy with instillation and dwell time using normal saline to promote bioburden reduction and granulation tissue formation. This was followed by the application of a dermal substitute combined with conventional negative pressure wound therapy to support dermal regeneration. Throughout the treatment course, multidisciplinary care was provided to optimize the management of systemic comorbidities.Outcome After four cycles of negative pressure wound therapy with instillation and dwell time, more than 70 percent of the wound bed, including previously exposed bone and tendon areas, was covered with healthy granulation tissue. Over the following three months, further tissue regeneration was achieved with the dermal substitute and negative pressure wound therapy. No additional surgical debridement was required, and limb preservation was successfully maintained without progression to systemic sepsis. Functionally, the patient ambulated with mobility assistance and reported minimal pain with good treatment acceptability. The patient subsequently died at month 5 from cardiovascular disease unrelated to the wound; wound stability through month 5 was recorded only in treating-team documentation.Conclusion This case demonstrates that a carefully staged multimodal adjuvant therapy protocol, incorporating negative pressure wound therapy with instillation and dwell time, dermal substitute application with negative pressure wound therapy, and multidisciplinary management of comorbidities, can serve as an effective limb salvage strategy in high-risk patients with diabetic foot ulcer-associated necrotizing fasciitis and extensive soft tissue defects when conventional reconstructive options are not feasible. This multimodal protocol may inform practice in high-risk or resource-limited settings.
C1 [Chen, Shiuan-Fu] Changhua Christian Hosp, Dept Med Educ, Div Gen Practice, Changhua, Taiwan.
   [Chang, Chang-Cheng] China Med Univ, Coll Med, Sch Med, Taichung, Taiwan.
   [Chang, Chang-Cheng] China Med Univ, Dept Cosmeceut, Taichung, Taiwan.
   [Chang, Chang-Cheng] China Med Univ Hosp, Dept Surg, Div Plast & Reconstruct Surg, Taichung, Taiwan.
   [Chang, Chang-Cheng] China Med Univ Hosp, Aesthet Med Ctr, Taichung, Taiwan.
C3 Changhua Christian Hospital; China Medical University Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan
RP Chang, CC (通讯作者)，China Med Univ, Coll Med, Sch Med, Taichung, Taiwan.; Chang, CC (通讯作者)，China Med Univ, Dept Cosmeceut, Taichung, Taiwan.; Chang, CC (通讯作者)，China Med Univ Hosp, Dept Surg, Div Plast & Reconstruct Surg, Taichung, Taiwan.; Chang, CC (通讯作者)，China Med Univ Hosp, Aesthet Med Ctr, Taichung, Taiwan.
EM changcc1975@gmail.com
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD FEB 5
PY 2026
VL 13
AR 1687275
DI 10.3389/fsurg.2026.1687275
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DX5AG
UT WOS:001694409300001
PM 41727898
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ahmed, AA
   Alasso, AAO
   Ibrahim, IG
   Omar, NMS
AF Ahmed, Abdullahi Ahmed
   Alasso, Abdirahman Ahmed Omar
   Ibrahim, Ismail Gedi
   Omar, Nasteho Mohamed Sheikh
TI Application of endoscopic vacuum-assisted closure therapy for
   oesophageal perforation: first case report in East Africa
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Oesophageal perforation; Endoscopic vacuum-assisted closure; Case
   report; East africa
ID LEAKS
AB Introduction and importance Oesophageal perforation is a critical condition associated with high morbidity and mortality, requiring rapid diagnosis and effective treatment. Endoscopic vacuum-assisted closure (EVAC) therapy has emerged as an innovative and effective approach for managing oesophageal perforations, offering advantages such as enhanced healing shorter hospital stay and reduced complications. Case presentation We report a case of oesophageal perforation complicated by subcutaneous emphysema, pleural effusions, and mild pneumothorax in a 40-year-old woman who presented with facial, neck, and chest swelling, dyspnoea, dysphagia, and fever following intubation during laparoscopic gynaecological surgery. Imaging revealed a defect in the oesophageal wall at the C5-C6 level with significant contrast extravasation and air tracking. Emergency surgical interventions, including chest tube placement, were performed, followed by a multidisciplinary treatment plan incorporating EVAC therapy. Post-treatment imaging demonstrated complete resolution of the perforation and associated complications. Clinical discussion This case highlights the utility of EVAC therapy as a safe and effective modality in the comprehensive management of oesophageal perforation, underscoring its role in improving patient outcomes. Conclusion EVAC therapy represents a promising approach for managing oesophageal perforations. It offers a minimally invasive alternative to traditional surgical treatment in resource-limited settings.This modality can potentially enhance healing, reduce complications, and lower costs.
C1 [Ahmed, Abdullahi Ahmed; Omar, Nasteho Mohamed Sheikh] Mogadishu Somali Turkey Training & Res Hosp, Dept Emergency Med, Mogadishu, Somalia.
   [Alasso, Abdirahman Ahmed Omar] Mogadishu Somali Turkey Training & Res Hosp, Dept Gen Surgary, Mogadishu, Somalia.
   [Ibrahim, Ismail Gedi] Mogadishu Somali Turkey Training & Res Hosp, Dept Radiol, Mogadishu, Somalia.
   [Ahmed, Abdullahi Ahmed] Basaksehir Cam & Sakura City Hosp, Istanbul, Turkiye.
RP Ahmed, AA (通讯作者)，Mogadishu Somali Turkey Training & Res Hosp, Dept Emergency Med, Mogadishu, Somalia.; Ahmed, AA (通讯作者)，Basaksehir Cam & Sakura City Hosp, Istanbul, Turkiye.
EM drfuqsade@gmail.com
OI Alasso, -Abdi/0000-0002-0778-4720
CR American Society for Gastrointestinal Endoscopy Technology Committee, 2024, IGIE, V3, P333, DOI [10.1016/j.igie.2024.06.003, 10.1016/j.igie.2024.06.003]
   Biancari F, 2013, WORLD J SURG, V37, P1051, DOI 10.1007/s00268-013-1951-7
   Dasari BVM, 2014, ANN SURG, V259, P852, DOI 10.1097/SLA.0000000000000564
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NR 13
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD FEB 1
PY 2026
VL 21
IS 1
AR 104
DI 10.1186/s13019-026-03857-9
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA EJ6MV
UT WOS:001702660000001
PM 41622226
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kim, KH
   Kim, KH
   Hwang, NH
   Kim, MJ
   Jeong, HC
   Chae, HK
   Han, JY
   Park, JH
AF Kim, Kyu Hyup
   Kim, Kyul Hee
   Hwang, Na-Hyun
   Kim, Min Jeong
   Jeong, Hyun Cheol
   Chae, Han Kyu
   Han, Ji-Yeon
   Park, Jun Ho
TI Gender-affirming robot-assisted sigmoid vaginoplasty: Outcomes and
   complications from a retrospective review of 12 cases
SO MEDICINE
LA English
DT Article
DE gender-affirming surgery; robot-assisted surgery; sigmoid vaginoplasty;
   transgender women; postoperative complications
ID COLON VAGINOPLASTY; TRANSGENDER WOMEN
AB Gender-affirming surgery significantly improves the quality of life in transfeminine individuals. Among the various techniques available, sigmoid colon vaginoplasty offers both anatomical and functional advantages. However, conventional approaches are associated with high morbidity. Thus, we aimed to evaluate the outcomes of robot-assisted sigmoid vaginoplasty, emphasizing the complications and clinical results. Between July 2021 and March 2023, 12 patients underwent robot-assisted sigmoid vaginoplasty. Preoperative assessments included colonoscopy and abdominal computed tomography. Flap preparation and canal dissection were performed using a da Vinci XI platform. Postoperative management included vacuum-assisted closure dressing, bed rest, and vaginal dilator use. Clinical outcomes, complications, and sexual activity (SA) were retrospectively analyzed. The mean patient age was 27.9 years (95% confidence interval [CI]: 21.8-34.0). The mean total operative time was 544.8 minutes (95% CI: 494.4-595.1). Intraoperative complications were not observed. The mean vaginal length achieved was 14.6 cm (95% CI: 12.9-16.3), with no cases of vaginal stenosis. Positive SA was reported in 75% of the cases. The overall postoperative complication rate was 41.7% (5/12). Complications included ileus (2 cases, Grade II), vaginal prolapse (1 case, Grade IIIa), anastomotic leakage (1 case, Grade IIIb), and colon flap necrosis (1 case, Grade IIIb), all of which were successfully managed. Robot-assisted sigmoid vaginoplasty demonstrated favorable functional and aesthetic outcomes with manageable complications. However, anastomotic leakage and flap necrosis highlight the importance of careful consideration of vascular supply. Further comparative studies are required to evaluate its advantages over peritoneal vaginoplasty.
C1 [Kim, Kyul Hee; Jeong, Hyun Cheol; Park, Jun Ho] Hallym Univ, Coll Med, Kangdong Sacred Heart Hosp, Dept Surg, 445 Gil 1 Dong, Seoul 05355, South Korea.
   [Hwang, Na-Hyun; Kim, Min Jeong] Hallym Univ, Coll Med, Kangdong Sacred Heart Hosp, Dept Plast Surg, Seoul, South Korea.
   [Hwang, Na-Hyun; Kim, Min Jeong; Jeong, Hyun Cheol; Chae, Han Kyu; Han, Ji-Yeon; Park, Jun Ho] Hallym Univ, Coll Med, Kangdong Sacred Heart Hosp, LGBTQ Ctr, Seoul, South Korea.
   [Chae, Han Kyu; Han, Ji-Yeon] Hallym Univ, Kangdong Sacred Heart Hosp, Coll Med, Dept Urol, Seoul, South Korea.
C3 Hallym University; Hallym University; Hallym University; Hallym
   University
RP Park, JH (通讯作者)，Hallym Univ, Coll Med, Kangdong Sacred Heart Hosp, Dept Surg, 445 Gil 1 Dong, Seoul 05355, South Korea.
EM yato31778@hanmail.net; yato31778@hanmail.net; priscah@kdh.or.kr;
   yato31778@hanmail.net; koulich@naver.com; hanqsinopoli@gmail.com;
   jyincomo@gmail.com; zooono@hanmail.net
RI Han, Jiyeon/KII-6637-2024
OI Kim, Kyu Hyup/0009-0003-9032-1835
FU Kangdong Sacred Heart Hospital, Hallym University [2025-01]
FX This research was supported by Kangdong Sacred Hospital Research Fund
   2025 (2025-01).
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NR 24
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 27
PY 2026
VL 105
IS 9
AR e47849
DI 10.1097/MD.0000000000047849
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EK0YU
UT WOS:001702962900030
PM 41760062
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yang, CX
   Liu, QY
   Chen, HY
AF Yang, Chenxi
   Liu, Quanyong
   Chen, Hongyi
TI Antibiotic-Loaded Bone Cement-Induced Membrane and Skin Grafting in
   Elderly Patients with Refractory Lower Limb Wounds
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID COST
AB Refractory lower limb wounds in the elderly population represent a significant and growing clinical challenge, often complicated by factors such as chronic infection, poor tissue vascularization, and multiple comorbidities. These wounds frequently lead to prolonged healing times, increased healthcare costs, and diminished quality of life for affected patients. This protocol article describes a detailed two-stage surgical technique that utilizes antibiotic-loaded polymethyl methacrylate (PMMA) bone cement to induce a vascularized membrane, followed by secondary skin grafting. The procedure is systematically outlined, beginning with patient selection criteria and progressing through radical wound debridement, intraoperative preparation and implantation of the vancomycin-loaded cement spacer, postoperative care, and subsequent spacer removal with application of a split-thickness skin graft onto the newly formed induced membrane. We provide a direct comparative framework against the conventional vacuum sealing drainage (VSD) technique. In this retrospective cohort study, representative results demonstrate that this method contributes to local infection control, as both groups showed a reduction in culture positivity postoperatively. Furthermore, it promotes a more robust angiogenic response within the induced membrane. Although the final wound healing rate at 70 days was comparable between groups, the PMMA method demonstrated a significantly shorter time to complete healing compared to VSD. The protocol also presents potential benefits in reducing the overall economic and psychological burden on patients. This comprehensive guide enables the replication of a promising surgical strategy for managing complex lower limb wounds in elderly patients.
C1 [Yang, Chenxi; Liu, Quanyong] Peoples Hosp Yuhuan, Dept Spine Hand & Foot Surg, Taizhou, Peoples R China.
   [Chen, Hongyi] Peoples Hosp Yuhuan, Dept Pathol, Yuhuan, Peoples R China.
RP Chen, HY (通讯作者)，Peoples Hosp Yuhuan, Dept Pathol, Yuhuan, Peoples R China.
EM chy960218@163.com
FU Taizhou Science and Technology Plan Project [23ywb148]
FX The authors thank the nursing staff and colleagues at the Department of
   Spine, Hand and Foot Surgery, The People's Hospital of Yuhuan, for their
   support in patient care and data collection. This work was supported by
   the Taizhou Science and Technology Plan Project (Grant No. 23ywb148) .
CR Anagnostakos K, 2009, J BIOMED MATER RES B, V90B, P467, DOI 10.1002/jbm.b.31281
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NR 21
TC 0
Z9 0
U1 1
U2 1
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD FEB
PY 2026
IS 228
AR e70361
DI 10.3791/70361
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EL2HY
UT WOS:001703734100001
PM 41838703
DA 2026-07-24
ER
PT J
AU Fernández-de-Velasco, D
   Carnero-Alcázar, M
   Reguillo-Lacruz, FJ
   Torrón, JMM
   Villamor-Jiménez, C
   Calleja-Sanz, J
   Ruiz-Alvarez, P
   Maroto-Castellanos, L
   Moores, S
   Alvarez-de-Arcaya, MA
AF Fernandez-de-Velasco, David
   Carnero-Alcazar, Manuel
   Reguillo-Lacruz, Fernando-Jose
   Torron, Juan-Miguel Miranda
   Villamor-Jimenez, Cristina
   Calleja-Sanz, Jorge
   Ruiz-Alvarez, Pilar
   Maroto-Castellanos, Luis
   Moores, Sally
   Alvarez-de-Arcaya, Maria Arantzazu
TI Multi-Disciplinary and Protocol-Driven Post-Operative Care Reduces
   Incidence of Post-Sternotomy Mediastinitis
SO SURGICAL INFECTIONS
LA English
DT Review; Early Access
DE cardiac procedure; multidisciplinary care; negative pressure wound
   therapy; outpatient follow-up; post-sternotomy mediastinitis; sternotomy
ID INFECTIONS; THERAPY; SURVEILLANCE
AB Background: Post-sternotomy mediastinitis (PSM) is a rare but life-threatening complication of cardiac surgical procedures. This study evaluated the impact of a structured multi-disciplinary post-discharge care bundle on PSM incidence. Methods: A single-center, retrospective cohort study compared the incidence of PSM two years before and after implementation of a care bundle led by a multi-disciplinary team. The intervention included telephonic monitoring, a specialized wound-care clinic, and a standardized two-phase wound management protocol incorporating single-use negative pressure wound therapy. Outcomes were assessed using chi-square tests and logistic regression adjusted with propensity scores and inverse probability weighting. To rule out a temporal trend in newly identified wound infections, we performed a linear regression using bimonthly incident counts as the outcome. Results: A total of 1,197 patients underwent median sternotomy between May 1, 2018, and April 30, 2022. The crude incidence of PSM was 3.32% in the pre-implementation group and 1.56% in the post-implementation group (p = 0.058). After adjustment with inverse probability of treatment weighting, the care bundle was associated with a significant reduction in PSM rate (absolute risk difference 1.96%, 95% confidence interval [CI]: 0.54-3.87; p = 0.044; relative reduction 59%, 95% CI: 16.3%-116%), despite a higher baseline surgical risk in the post-implementation cohort (higher EuroSCORE II, more urgent procedures, greater need for vasoactive support). The rate of newly identified wound infections did not exhibit a significant time trend (beta = -0.43; p = 0.299). Conclusion: Implementation of a multi-disciplinary care bundle is significantly associated with a reduction in PSM incidence in cardiac sternotomy patients, underscoring the importance of structured outpatient wound surveillance.
C1 [Fernandez-de-Velasco, David; Villamor-Jimenez, Cristina] Hosp Univ Alcorcon, Dept Internal Med, C Budapest 1, Madrid 28922, Spain.
   [Carnero-Alcazar, Manuel; Reguillo-Lacruz, Fernando-Jose; Torron, Juan-Miguel Miranda; Ruiz-Alvarez, Pilar; Maroto-Castellanos, Luis] Hosp Clin Univ San Carlos, Dept Cardiac Surg, Madrid, Spain.
   [Calleja-Sanz, Jorge; Alvarez-de-Arcaya, Maria Arantzazu] Univ Complutense Madrid, Hosp Univ Clin San Carlos, Div Hosp Med, Dept Med, Madrid, Spain.
   [Moores, Sally] Smith & Nephew, Global Clin Strategy, Kingston Upon Hull, England.
C3 Alcorcon Foundation University Hospital; Complutense University of
   Madrid; Smith & Nephew
RP Fernández-de-Velasco, D (通讯作者)，Hosp Univ Alcorcon, Dept Internal Med, C Budapest 1, Madrid 28922, Spain.
EM dfernandezv@salud.madrid.org
RI Carnero, Manuel/AAF-4073-2021; Maroto, Luis/IUO-4884-2023; Álvarez-de
   Arcaya, Arántzazu/OUH-3896-2025
OI Álvarez-de Arcaya Vicente, Arántzazu/0000-0001-8998-5851
CR Bitkover CY, 1998, ANN THORAC SURG, V65, P36, DOI 10.1016/S0003-4975(97)01003-5
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NR 25
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD 2026 MAR 4
PY 2026
DI 10.1177/10962964261428654
EA MAR 2026
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA EQ2OQ
UT WOS:001707151400001
PM 41781336
DA 2026-07-24
ER
PT J
AU Shang, YR
   Guo, SY
   Song, SK
   Tong, MY
   Gong, Y
   Liu, X
   Li, Z
   Song, MZ
AF Shang, Yuru
   Guo, Shiyi
   Song, Shukun
   Tong, Mengying
   Gong, Ying
   Liu, Xin
   Li, Zhen
   Song, Mingzhi
TI Negative Pressure Wound Therapy and Ultrasound Monitoring for
   Fracture-Related Infection of the Proximal Femur: A Case Report
SO INFECTION AND DRUG RESISTANCE
LA English
DT Article
DE fracture-related infection; hip fracture; negative pressure wound
   therapy; surgical wound infection; ultrasonography; wound healing
ID COMPLICATIONS
AB Background: Fracture-related infection (FRI) is one of the main complications of hip fracture. Negative pressure wound therapy (NPWT) seems to be a potential solution for FRI, because of offering exudate management, drainage enhancement, and tissue repair. Additionally, ultrasound cannot be ignored because of its role in evaluating musculoskeletal tissue infections. Case Presentation: A 55-year-old man mainly suffered from a fracture of the right proximal femur. The fracture was classified as AO/OTA 31-A3. The patient had a history of smoking. After internal fixation of the fracture and other symptomatic treatment, the patient was discharged. However, the surgical incision dehisced one month later. After examination, the patient was diagnosed with FRI with wound disruption and sinus tract formation. The blurred parafemoral shadow in X-ray, positive bacterial culture result, abnormal secretions, and elevated C-reactive protein and erythrocyte sedimentation rate were the bases for diagnosing FRI. In the course of treatment, we made full use of NPWT following limited debridement surgery to effectively treat FRI, and then continuously monitored the changes of lesions in deep infected areas through ultrasound detection. Intravenous infusion of ceftazidime and local rinsing with vancomycin solution were applied during the treatment process. Follow-up results showed that the patient had no recurrence of infection or other adverse events three months after treatment. Conclusion: This case shows that NPWT combined with ultrasound monitoring can control early fracture-related infection and allow implant retention. This treatment method may be applicable to areas with scarce medical resources. But larger-scale validation is still needed before clinical adoption.
C1 [Shang, Yuru] Shenzhen Univ, South China Hosp, Med Sch, Dept Gastrointestinal Surg, Shenzhen, Guangdong, Peoples R China.
   [Shang, Yuru] Shenzhen Univ, Guangdong Key Lab Biomed Measurements & Ultrasound, Natl Reg Key Technol Engn Lab Med Ultrasound, Sch Biomed Engn,Med Sch, Shenzhen, Guangdong, Peoples R China.
   [Guo, Shiyi; Song, Mingzhi] Jining Med Univ, Inst Translat Med, Rizhao, Shandong, Peoples R China.
   [Guo, Shiyi] Jining Med Univ, Sch Pharm, Rizhao, Shandong, Peoples R China.
   [Song, Shukun] Chaoyang Cty Cent Hosp, Dept Orthopaed, Chaoyang, Liaoning, Peoples R China.
   [Tong, Mengying] Dalian Med Univ, Affiliated Hosp 1, Dept Ultrasound, Dalian, Liaoning, Peoples R China.
   [Gong, Ying] Dalian Med Univ, Affiliated Hosp 1, Dept Nursing, Dalian, Liaoning, Peoples R China.
   [Gong, Ying] Dalian Med Univ, Affiliated Hosp 1, Dept Orthopaed, Dalian, Liaoning, Peoples R China.
   [Liu, Xin; Li, Zhen] Shenzhen Pingshan Tradit Chinese Med Hosp, Shenzhen Pingle Orthoped Hosp, Printing Ctr 3D, Shenzhen, Guangdong, Peoples R China.
   [Li, Zhen] Shenzhen Pingshan Tradit Chinese Med Hosp, Shenzhen Pingle Orthoped Hosp, Dept Nursing, Shenzhen, Guangdong, Peoples R China.
   [Song, Mingzhi] Jining Med Univ, Affiliated Hosp, Dept Orthoped, Jining, Shandong, Peoples R China.
   [Song, Mingzhi] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Sch Med, Shanghai, Shanghai, Peoples R China.
C3 Shenzhen University; Shenzhen University; Jining Medical University;
   Jining Medical University; Dalian Medical University; Dalian Medical
   University; Dalian Medical University; Jining Medical University;
   Shanghai Jiao Tong University
RP Song, MZ (通讯作者)，Jining Med Univ, Inst Translat Med, Rizhao, Shandong, Peoples R China.; Song, MZ (通讯作者)，Jining Med Univ, Affiliated Hosp, Dept Orthoped, Jining, Shandong, Peoples R China.; Song, MZ (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Sch Med, Shanghai, Shanghai, Peoples R China.
EM songmingzhi@sjtu.edu.cn
FU Shandong Taishan Scholars Young Experts Program [tsqn202507263]
FX This work was supported by Shandong Taishan Scholars Young Experts
   Program (No.tsqn202507263).
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NR 36
TC 0
Z9 0
U1 1
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2026
VL 19
AR 575912
DI 10.2147/IDR.S575912
PG 7
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA EQ4UX
UT WOS:001707303600001
PM 41809938
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Schnierer, M
   Haralambus, RMA
   Florczyk, A
AF Schnierer, M.
   Haralambus, R. M. A.
   Florczyk, A.
TI Disposable negative pressure wound therapy system enhances punch graft
   acceptance in equine distal limb wounds
SO EQUINE VETERINARY EDUCATION
LA English
DT Article; Early Access
DE horse; island grafts; skin grafts; VAC; wounds
ID MANAGEMENT
AB This case series describes the use of a disposable, canister-free negative pressure wound therapy (NPWT) system (PICO (R)) in combination with punch grafting for the treatment of distal limb wounds in three horses. Each horse presented with complex traumatic injuries resulting in delayed or inadequate healing of distal limb wounds. In all three cases, 6 mm full-thickness skin punch grafts were harvested from the neck and implanted into appropriately prepared wound beds. The PICO (R) system was applied post-operatively to support graft adherence and reduce complications such as infection. Bandage changes were performed between days 3 and 5, with NPWT maintained for up to 13 days. In all cases, the majority of grafts were successfully incorporated, with no signs of pain or adverse reactions to the NPWT system. Full epithelialisation was observed within 3-5 weeks post-grafting. The lightweight, user-friendly design of the PICO (R) system allowed for easier application compared to conventional NPWT systems and was well tolerated by the patients. These findings suggest that this method is a practical and effective adjunct to improve graft survival in the management of equine distal limb wounds.
C1 [Schnierer, M.; Haralambus, R. M. A.; Florczyk, A.] Univ Vet Med, Vienna, Austria.
C3 University of Veterinary Medicine Vienna
RP Schnierer, M (通讯作者)，Univ Vet Med, Vienna, Austria.
EM marlies.schnierer@gmail.com
CR Cantatore F, 2023, VET SCI, V10, DOI 10.3390/vetsci10080507
   Florczyk A, 2017, J EQUINE VET SCI, V55, P9, DOI 10.1016/j.jevs.2017.01.005
   Jordana M., 2011, USE VACUUM ASSISTED
   Kamus L, 2019, BMC VET RES, V15, DOI 10.1186/s12917-019-1829-5
   Krasner Diane L, 2002, Ostomy Wound Manage, V48, P38
   Rijkenhuizen ABM, 2005, PFERDEHEILKUNDE, V21, P413, DOI 10.21836/PEM20050503
   Schumacher J., 2019, EQUINE SURG, P381
   Smith & Nephew GmbH, 2025, US
NR 8
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0957-7734
EI 2042-3292
J9 EQUINE VET EDUC
JI Equine Vet. Educ.
PD 2026 MAR 5
PY 2026
DI 10.1111/eve.70068
EA MAR 2026
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA EQ8MQ
UT WOS:001707554700001
OA hybrid
DA 2026-07-24
ER
PT J
AU Iurilli, M
   Guarini, LB
   Di Bella, S
   Zerbato, V
   Papa, G
AF Iurilli, Martin
   Guarini, Luigi Bonat
   Di Bella, Stefano
   Zerbato, Verena
   Papa, Giovanni
TI Cutaneous Scedosporium infection mimicking malignancy in a kidney
   transplant recipient: A case report
SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
LA English
DT Article
DE Scedosporium; Cutaneous infection; Kidney transplantation; Voriconazole;
   Case report
ID FUNGAL-INFECTIONS; APIOSPERMUM; SUSCEPTIBILITY; VORICONAZOLE; THERAPY
AB Background: Cutaneous Scedosporium infection represents an extremely rare opportunistic fungal complication in solid-organ transplant recipients, often mimicking post-transplant skin malignancies due to chronic immunosuppression. Case presentation: A 75-year-old woman, kidney transplanted in 2022 for IgA nephropathy on tacrolimus, mycophenolate, and prednisone, developed progressive firm nodular lesions on the left lower limb over two months. Punch biopsy revealed granulomatous inflammation with septate hyphae on Gomori-Grocott stain; culture confirmed Scedosporium spp. CT excluded dissemination. Conclusion: Voriconazole (6 mg/kg loading dose, then 4 mg/kg maintenance dose) combined with surgical debridement, negative-pressure wound therapy, and skin grafting achieved complete healing at three months, with no recurrence at 12 months. Early biopsy is crucial to differentiate this rare entity from squamous cell carcinoma, enabling multidisciplinary success.
C1 [Iurilli, Martin; Papa, Giovanni] Trieste Univ Hosp ASUGI, Plast & Reconstruct Surg Unit, Trieste, Italy.
   [Iurilli, Martin; Di Bella, Stefano; Papa, Giovanni] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
   [Di Bella, Stefano; Zerbato, Verena] Trieste Univ Hosp ASUGI, Infect Dis Unit, Trieste, Italy.
C3 University of Trieste
RP Iurilli, M (通讯作者)，Cattinara Hosp, Plast & Reconstruct Surg Unit, Str Fiume 447, I-34149 Trieste, Italy.
EM martin.iurilli@phd.units.it
RI Di Bella, Stefano/K-8162-2016; Zerbato, Verena/KIH-8256-2024; Iurilli,
   Martin/OPO-3971-2025
OI Iurilli, Martin/0009-0007-4634-2582
CR Boyd ME, 2018, MED MYCOL CASE REP, V22, P52, DOI 10.1016/j.mmcr.2018.09.002
   Cortez KJ, 2008, CLIN MICROBIOL REV, V21, P157, DOI 10.1128/CMR.00039-07
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NR 19
TC 1
Z9 2
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0732-8893
EI 1879-0070
J9 DIAGN MICR INFEC DIS
JI Diagn. Microbiol. Infect. Dis.
PD JUN
PY 2026
VL 115
IS 2
AR 117347
DI 10.1016/j.diagmicrobio.2026.117347
PG 4
WC Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Microbiology
GA ES2WN
UT WOS:001708530700001
PM 41775156
OA hybrid
DA 2026-07-24
ER
PT J
AU Wang, YF
   Wang, TT
   Zheng, XY
   Ma, CW
   Cao, MC
   He, XY
   Li, HX
   Li, ZY
   Wang, ZJ
   Jia, RF
AF Wang, Yafei
   Wang, Tingting
   Zheng, Xinying
   Ma, Chunwei
   Cao, Mingcong
   He, Xiaoyang
   Li, Haixia
   Li, Zhaoyang
   Wang, Zhijing
   Jia, Rufeng
TI Application of vacuum sealing drainage in perioperative patients with
   refractory wounds in orthopedics and prognostic analysis ☆
SO CURRENT PROBLEMS IN SURGERY
LA English
DT Article
ID THERAPY
C1 [Wang, Yafei; Zheng, Xinying; Jia, Rufeng] Cangzhou Cent Hosp, Dept Nursing, 16 Xinhua West Rd, Cangzhou 061001, Hebei, Peoples R China.
   [Wang, Tingting] Cangzhou Cent Hosp, Dept Neu Ropsychol Cognit Impairment, Cangzhou, Hebei, Peoples R China.
   [Ma, Chunwei; He, Xiaoyang; Li, Haixia] Yanshan Cty Peoples Hosp, Dept Surg, Yanshan, Hebei, Peoples R China.
   [Cao, Mingcong] Cangzhou Cent Hosp, Dept Ophthalmol, Cangzhou, Hebei, Peoples R China.
   [Li, Zhaoyang] Cangzhou Cent Hosp, Dept Gen Adm, Cangzhou, Hebei, Peoples R China.
   [Wang, Zhijing] Cangzhou Cent Hosp, Dept Anesthesiol, Cangzhou, Hebei, Peoples R China.
RP Jia, RF (通讯作者)，Cangzhou Cent Hosp, Dept Nursing, 16 Xinhua West Rd, Cangzhou 061001, Hebei, Peoples R China.
EM jiarfczch@163.com
RI /HRC-5468-2023
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0011-3840
EI 1535-6337
J9 CURR PROB SURG
JI Curr. Probl. Surg.
PD APR
PY 2026
VL 77
AR 101963
DI 10.1016/j.cpsurg.2025.101963
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ET5BW
UT WOS:001709361500001
PM 41942261
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ma, H
   Zhang, B
   Xue, YH
   Liu, QR
   Chen, JH
   Wang, P
   Ge, H
AF Ma, Hao
   Zhang, Bei
   Xue, Yahong
   Liu, Qingrui
   Chen, Jiahui
   Wang, Pei
   Ge, Hao
TI Negative pressure wound therapy for perianal necrotizing fasciitis: case
   report and literature review
SO FRONTIERS IN SURGERY
LA English
DT Article
DE fecal diversion; fournier's gangrene; negative pressure wound therapy
   (NPWT); perianal necrotizing fasciitis; radical debridement;
   vacuum-assisted closure (VAC)
AB Perianal necrotizing fasciitis (PNF) is a life-threatening soft tissue infection with high mortality. Despite the established role of radical debridement, outcomes are often hindered by late diagnosis and suboptimal postoperative care. While negative pressure wound therapy (NPWT) promotes complex wound healing, its synergistic application with radical debridement in PNF requires further validation. We report a case of extensive PNF that demonstrated the limitations of traditional interventions. By utilizing an integrated strategy of extended-incision radical debridement and early NPWT, we achieved rapid infection control and accelerated wound healing. This case suggests that such a combined technical framework can overcome clinical challenges and significantly improve PNF prognosis.
C1 [Ma, Hao; Zhang, Bei; Xue, Yahong; Wang, Pei] Nanjing Univ Chinese Med, Nanjing Hosp Chinese Med, Dept Anorectal Ctr, Nanjing, Peoples R China.
   [Liu, Qingrui; Chen, Jiahui; Ge, Hao] Nanjing Univ Chinese Med, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Zhang, B (通讯作者)，Nanjing Univ Chinese Med, Nanjing Hosp Chinese Med, Dept Anorectal Ctr, Nanjing, Peoples R China.
EM 13913939440@163.com
FU Bei Famous Chinese Medicine Practitioner Studio
FX The author(s) declared that financial support was received for this work
   and/or its publication. This study received funding from the Zhang Bei
   Famous Chinese Medicine Practitioner Studio, which covered the costs
   associated with the research.
CR Bentin JM., 2023, UGESKR LAEGER, V185, pV12220778
   Iacovelli V, 2021, WORLD J UROL, V39, P121, DOI 10.1007/s00345-020-03170-7
   Ismayilzade M, 2023, ANN PLAS SURG, V90, P356, DOI 10.1097/SAP.0000000000003517
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NR 11
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD FEB 24
PY 2026
VL 13
AR 1747876
DI 10.3389/fsurg.2026.1747876
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EU0KC
UT WOS:001709725100001
PM 41815779
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, WR
   Chen, J
   Liu, YM
   Xie, ZF
   Fu, T
AF Li, Wanru
   Chen, Jun
   Liu, Yanming
   Xie, Zefeng
   Fu, Tao
TI Analysis of pathogenic bacteria of oral and maxillofacial space
   infection and the effect of vacuum sealing drainage treatment
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Oral and maxillofacial space infection; pathogen analysis; negative
   pressure drainage; clinical thera-peutic effect; inflammatory factors
ID PRESSURE WOUND THERAPY; MANAGEMENT
AB Objective: To investigate the pathogenic spectrum of oral and maxillofacial space infection and evaluate the clinical efficacy of vacuum sealing drainage (VSD) in its treatment. Methods: A retrospective analysis was performed on 118 patients with oral and maxillofacial space infection admitted to the Department of Stomatology, the Second Affiliated Hospital of Zhejiang University School of Medicine, from January 2021 to December 2023. All patients underwent pathogenic bacteria detection, and were divided into a conventional incision drainage group (n=72) and a VSD group (n=46) by treatment method. The clinical efficacy, recovery-related indicators, pain scores and serum inflammatory factor levels were compared between the two groups. Results: The most frequent infection sites were the masseteric, buccal and infraorbital spaces in turn. Staphylococcus aureus, Staphylococcus epidermidis and Klebsiella pneumoniae were the dominant pathogens. Compared with the conventional group, the VSD group showed a higher clinical effective rate, significantly shorter wound healing time, antibiotic course and hospital stay (all P < 0.05). Meanwhile, the VSD group had lower pain rating index (PRI), visual analogue scale (VAS), present pain intensity (PPI) scores, and lower serum levels of tumor necrosis factor-alpha (TNF-alpha), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) (all P < 0.05). Conclusion: Oral and maxillofacial space infection is mainly caused by Gram-positive cocci. VSD can enhance clinical efficacy, alleviate pain, reduce inflammatory response, and shorten the duration of antibiotic use and hospitalization, which is worthy of clinical promotion.
C1 [Li, Wanru; Chen, Jun; Liu, Yanming; Xie, Zefeng; Fu, Tao] Zhejiang Univ, Affiliated Hosp 2, Dept Oral & Maxillofacial Surg, Sch Med, 88 Jiefang Rd, Hangzhou 31000, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Fu, T (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Dept Oral & Maxillofacial Surg, Sch Med, 88 Jiefang Rd, Hangzhou 31000, Zhejiang, Peoples R China.
EM futao13858083077@126.com
CR Alhudaithi AS, 2025, CRANIOMAX TRAUM REC, V18, DOI 10.3390/cmtr18030031
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NR 27
TC 0
Z9 0
U1 3
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2026
VL 18
IS 2
BP 1541
EP 1552
DI 10.62347/RJFS1052
PG 12
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA EU8PH
UT WOS:001710284600011
PM 41868901
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU de la Fuente, PZ
   Castillo, F
   Diban, N
   Lázaro-Martínez, JL
   Revilla, FQ
   Ruiz, GG
   Sancibrian, R
   Peralta, G
AF Zorrilla de la Fuente, Patricia
   Castillo, Federico
   Diban, Nazely
   Lazaro-Martinez, Jose Luis
   Quevedo Revilla, Fernando
   Garcia Ruiz, Gerardo
   Sancibrian, Ramon
   Peralta, Galo
TI Particulate Evacuation Under NPWT: Bench Evaluation of a Multilayer Foam
   Prototype Versus Commercial Dressings in a Simulated Exudate Model
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE exudates; negative-pressure dressings; negative-pressure wound therapy;
   wound healing; wounds
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY
AB Negative pressure wound therapy (NPWT) is widely used to facilitate healing by improving local perfusion, reducing edema and controlling exudate. The porous foam dressing is central to NPWT effectiveness, however, its performance in viscous, particle-rich exudates remains challenging. Standard industry tests often rely on protein-free aqueous solutions, which overlook the complex rheology and particulate load of real wounds. This study reports a bench evaluation of a multilayer foam prototype compared with three commercial dressings under NPWT, using a simulated viscous exudate with suspended particles. We recorded 60-min drainage curves and quantified effluent turbidity as a simple, interpretable proxy for particulate transport, summarised as percentage of input turbidity recovered. The mass-based endpoint (percent solid matter recovered) showed the same ranking as turbidity. At -75 mmHg, the prototype recovered 31.6% of input turbidity, exceeding commercial foams (<= 9.7%). At -125 mmHg, particulate recovery decreased across all dressings (<= 9.1%). A matrix-only control indicated that commercial effluents, particularly at -75 mmHg, clustered near background level, whereas the prototype evacuated substantially more particulate while maintaining robust fluid drainage. These findings suggest that moderate negative pressure and multilayer architecture can help preserve channel patency and reduce clogging in complex exudates. We highlight the need for test methodologies that incorporate viscosity and particulate content, and for practical guidance that links dressing architecture and pressure settings to exudate characteristics. Prospective validation, including larger-sample confirmation, particle-size distributions and ultimately clinical endpoints, is warranted.
C1 [Zorrilla de la Fuente, Patricia; Castillo, Federico; Diban, Nazely; Quevedo Revilla, Fernando; Garcia Ruiz, Gerardo; Peralta, Galo] Inst Invest Sanitaria Valdecilla IDIVAL, Santander, Spain.
   [Zorrilla de la Fuente, Patricia; Sancibrian, Ramon] Univ Cantabria, Santander, Spain.
   [Castillo, Federico] Hosp Univ Marques de Valdecilla, Santander, Spain.
   [Diban, Nazely] Univ Cantabria, Dept Chem & Biomol Engn, Santander, Spain.
   [Lazaro-Martinez, Jose Luis] Univ Complutense Madrid, Madrid, Spain.
   [Lazaro-Martinez, Jose Luis] Hosp Clin San Carlos Madrid IdISSC, Inst Invest Sanitaria, Madrid, Spain.
C3 Hospital Universitario Marques de Valdecilla (HUMV); Universidad de
   Cantabria; Hospital Universitario Marques de Valdecilla (HUMV);
   Universidad de Cantabria; Complutense University of Madrid
RP de la Fuente, PZ (通讯作者)，Inst Invest Sanitaria Valdecilla IDIVAL, Santander, Spain.; de la Fuente, PZ (通讯作者)，Univ Cantabria, Santander, Spain.
EM patricia.zorrilla@idival.org
RI MARTINEZ, JOSE/AAE-2268-2021; Diban, Nazely/AAA-4459-2019
OI Diban, Nazely/0000-0002-2636-6305
FU Instituto de Investigacin Sanitaria Valdecilla [DTEC21/01, DTEC25/01]
FX This work has been made possible by a research grant (DTEC21/01) and
   grant (DTEC25/01) from Instituto de Investigacion Sanitaria Valdecilla
   (IDIVAL).
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 13
TC 1
Z9 1
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR 10
PY 2026
VL 23
IS 3
AR e70872
DI 10.1111/iwj.70872
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EV9FE
UT WOS:001711007800001
PM 41807305
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Vidiscák, M
   Hajská, M
   Panyko, A
   Peter, Z
   Dubovsky, M
AF Vidiscak, Marian
   Hajska, Marianna
   Panyko, Arpad
   Peter, Zahorec
   Dubovsky, Martin
TI How to Prevent Surgical Site Infection of Laparotomy Incisions Using
   Negative Pressure Wound Therapy
SO BRATISLAVA MEDICAL JOURNAL
LA English
DT Article
DE Negative pressure; Complication prevention; Laparotomy incision
AB BackgroundSurgical site infection (SSI) after laparotomy remains a major source of morbidity and cost. Closed-incision negative pressure wound therapy (ciNPWT) has been proposed to prevent wound complications in high-risk patients, yet real-world evidence from abdominal surgery remains heterogeneous. We report our first experience with SSI prevention using ciNPWT in open abdominal surgery.MethodsWe conducted a retrospective clinical study of adult patients undergoing laparotomy who received ciNPWT (Prevena (TM); continuous - 125 mmHg) applied within 24 h post-closure and maintained for 6 days. The primary outcome was uncomplicated primary intention healing through suture removal (prevention "success"). Demographics, comorbidities (including diabetes, obesity, cardiovascular disease), inflammatory markers, and glycemia were collected. Logistic regression explored associations between failure and comorbidity burden. The ciNPWT group was compared with a control group of 20 patients who did not receive ciNPWT after laparotomy.ResultsTwenty patients received a single ciNPWT cycle; overall prevention success was 80%. Failure occurred in 20%. Sex and admission type were not significantly associated with outcome; median age was 69 years in successes versus 75.5 years in failures (p = 0.155). No individual comorbidity showed a significant association with failure after multiplicity adjustment. Each additional comorbidity showed a non-significant trend toward lower failure odds (OR 0.45, 95% CI 0.16-1.27; p = 0.13). Uncomplicated wound healing was achieved in 80% (16/20) of patients treated with ciNPWT compared with 45% (9/20) in the control group. (Fisher's exact test, p = 0.048; OR = 4.89), indicating borderline statistical significance.ConclusionsStandardized ciNPWT after laparotomy was feasible and associated with higher uncomplicated healing rates. Despite borderline statistical significance, the findings support the potential benefit of ciNPWT and justify further controlled studies.
C1 [Vidiscak, Marian; Hajska, Marianna; Panyko, Arpad; Dubovsky, Martin] Comenius Univ, Fac Med, Dept Surg 4, Bratislava, Slovakia.
   [Peter, Zahorec] Comenius Univ, Fac Med, Dept Burns & Reconstruct Surg, Bratislava, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava
RP Hajská, M (通讯作者)，Comenius Univ, Fac Med, Dept Surg 4, Bratislava, Slovakia.
EM marianna.hajska@fmed.uniba.sk
RI Panyko, Arpád/AAQ-6309-2020; Vidiscak, Marian/AAZ-6765-2021
OI Panyko, Arpád/0000-0002-1895-1790; Hajská, Marianna/0000-0002-0822-8929;
   
FU Comenius University in Bratislava
FX Open access funding provided by The Ministry of Education, Science,
   Research and Sport of the Slovak Republic in cooperation with Centre for
   Scientific and Technical Information of the Slovak Republic
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NR 20
TC 0
Z9 0
U1 2
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PD APR
PY 2026
VL 127
IS 4
BP 1707
EP 1712
DI 10.1007/s44411-026-00566-6
EA MAR 2026
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FL4ON
UT WOS:001711250800001
OA gold
DA 2026-07-24
ER
PT J
AU Di Nunzio, TGR
   Farhadi, J
   Grufman, V
   Speck, NE
AF Di Nunzio, Tiago G. Reina
   Farhadi, Jian
   Grufman, Vendela
   Speck, Nicole E.
TI Optimizing perioperative care in autologous breast reconstruction: a
   narrative review
SO GLAND SURGERY
LA English
DT Article
DE Autologous breast reconstruction; perioperative optimization;
   nutritional support; metabolic modulation; wound healing
ID HYPERBARIC-OXYGEN TREATMENT; NEGATIVE-PRESSURE THERAPY; GUIDELINE
   CLINICAL NUTRITION; QUALITY-OF-LIFE; ENHANCED RECOVERY; WOUND THERAPY;
   DONOR-SITE; CANCER-PATIENTS; POSTOPERATIVE COMPLICATIONS; REPERFUSION
   INJURY
AB Background and Objective: Autologous breast reconstruction is a complex microsurgical procedure in which perioperative management critically influences surgical and patient-reported outcomes. Several physiological and perioperative strategies-including oxygenation enhancement, metabolic modulation, nutritional support and wound care-remain underexplored in this specific setting. This narrative review summarizes evidence on emerging approaches to perioperative optimization in autologous breast reconstruction and discusses their potential to improve recovery and long-term outcomes. Methods: A narrative literature review was conducted using PubMed (MEDLINE, Bethesda, MD, USA) and Scopus (Elsevier, Amsterdam, The Netherlands) for studies published in English up to October 2025. Reference lists of key reviews and consensus statements were manually screened to identify additional relevant publications. The selected literature was analyzed thematically to highlight evolving concepts and their reported impact on reconstructive outcomes. Key Content and Findings: Emerging strategies target perioperative physiology through systemic and local interventions. Hyperbaric oxygen therapy and closed-incision negative pressure wound therapy demonstrate potential benefits in improving perfusion, reducing edema, and lowering wound-related complications. Antioxidant and metabolic modulation, perioperative protein optimization, and preoperative carbohydrate loading may attenuate catabolic stress and support microvascular stability. Structured drain care and infection-prevention protocols further contribute to safer recovery. Evidence remains heterogeneous and limited in scope, but collectively these approaches point toward a more comprehensive and individualized perioperative management paradigm in reconstructive breast surgery. Conclusions: Optimizing perioperative care in autologous breast reconstruction requires an integrated framework that aligns surgical precision with systemic support. Emerging biological and metabolic interventions may complement established recovery practices, potentially improving flap outcomes and overall patient well-being. Prospective multicenter studies are needed to standardize protocols and determine their clinical impact.
C1 [Di Nunzio, Tiago G. Reina; Farhadi, Jian; Grufman, Vendela; Speck, Nicole E.] Affidea Plast Surg Grp, Seefeldstr 214, CH-8008 Zurich, Switzerland.
   [Farhadi, Jian] Univ Basel, Fac Med, Basel, Switzerland.
   [Speck, Nicole E.] Univ Hosp Basel, Dept Plast Reconstruct Aesthet & Hand Surg, Basel, Switzerland.
C3 University of Basel; University of Geneva; University of Basel
RP Di Nunzio, TGR (通讯作者)，Affidea Plast Surg Grp, Seefeldstr 214, CH-8008 Zurich, Switzerland.
EM dr.reinadinunzio@gmail.com
OI Reina Di Nunzio, Tiago Guillermo/0009-0005-8065-3865
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NR 125
TC 0
Z9 0
U1 0
U2 0
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2227-684X
EI 2227-8575
J9 GLAND SURG
JI Gland Surg.
PD FEB 28
PY 2026
VL 15
IS 2
AR 51
DI 10.21037/gs-2025-1-539
PG 17
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EW8GR
UT WOS:001711622300016
PM 41808815
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Tschann, P
   Ammann, Y
   Brunner, W
AF Tschann, Peter
   Ammann, Yannic
   Brunner, Walter
TI Management of colorectal anastomotic leakage: from Hartmann's procedure
   to modern endoluminal therapies
SO EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
LA English
DT Article; Early Access
DE Anastomotic leakage; Complication management; Minimal invasive
   management; Endoscopic negative pressure therapy; Hartmann's Procedure
ID PELVIC SEPSIS
AB PurposeAnastomotic leakage (AL) remains one of the most serious complications in colorectal surgery, with a substantial impact on morbidity, mortality, and long-term oncological outcomes. Although Hartmann's procedure has traditionally been considered the standard approach for managing anastomotic failure, its limitations-particularly the high rates of permanent stoma formation and impaired quality of life-have driven the development of less invasive treatment strategies.MethodsA comprehensive review of the literature was conducted to evaluate current concepts in the pathophysiology, diagnosis, and management of anastomotic leakage following colorectal surgery, with particular emphasis on minimally invasive and endoluminal treatment modalities.ResultsContemporary evidence indicates a shift toward individualized, minimally invasive management strategies tailored to patient condition and leakage severity. Vacuum-assisted and hybrid endoluminal techniques, including vacuum-assisted closure therapy and VAC stent systems, have emerged as promising alternatives to traditional surgical approaches, demonstrating favorable outcomes in selected patients and a potential reduction in long-term morbidity.ConclusionThis comprehensive review summarizes the current understanding of AL pathophysiology, diagnostic principles, and therapeutic strategies, with a special focus on the evolution of vacuum-assisted and hybrid endoluminal techniques such as the VAC stent. Optimal outcomes appear to depend on appropriate patient selection, early diagnosis, interdisciplinary collaboration between surgical and endoscopic teams, and the development of standardized treatment algorithms. Future efforts should focus on refining selection criteria, integrating multimodal expertise, and implementing perioperative optimization strategies.
C1 [Tschann, Peter; Ammann, Yannic; Brunner, Walter] Kantonsspital St Gallen, Dept Gen Visceral Endocrine & Transplant Surg, Hlth Ostschweiz, Rorschacherstr 95, CH-9007 St Gallen, Switzerland.
   [Tschann, Peter] LKH Feldkirch, Dept Gen Visceral & Thorac Surg, Carinagasse 47, A-6800 Feldkirch, Austria.
   [Tschann, Peter] Private Univ Principally Liechtenstein, Dorfstr 26, FL-9495 Triesen, Liechtenstein.
   [Tschann, Peter; Brunner, Walter] Paracelsus Med Univ Salzburg, Dept Surg, Strubergasse 21, A-5020 Salzburg, Austria.
C3 Kantonsspital St. Gallen; Paracelsus Private Medical University
RP Tschann, P (通讯作者)，Kantonsspital St Gallen, Dept Gen Visceral Endocrine & Transplant Surg, Hlth Ostschweiz, Rorschacherstr 95, CH-9007 St Gallen, Switzerland.
EM tschann.pe@gmail.com
RI Tschann, Peter/AAW-8212-2020
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   Hirst NA, 2014, COLORECTAL DIS, V16, P95, DOI 10.1111/codi.12411
   Jayne D, 2025, LANCET GASTROENTEROL, V10, P806, DOI 10.1016/S2468-1253(25)00101-3
   Kulkarni N, 2020, TECH COLOPROCTOL, V24, P1017, DOI 10.1007/s10151-020-02293-8
   Lambrichts DPV, 2019, LANCET GASTROENTEROL, V4, P599, DOI 10.1016/S2468-1253(19)30174-8
   Nijssen DJ, 2025, DIGEST SURG, V42, P185, DOI 10.1159/000546041
   Normann M, 2024, WORLD J SURG ONCOL, V22, DOI 10.1186/s12957-024-03316-6
   Raab S, 2025, EUR SURG, DOI [10.1007/s10353-025-00871-4, 10.1007/s10353-025-00871-4]
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   Ramser M, 2025, SURG ENDOSC, V39, P7356, DOI 10.1007/s00464-025-12116-2
   Secher J, 2023, LANGENBECK ARCH SURG, V408, DOI 10.1007/s00423-023-02967-5
   Shaban F, 2018, INT J SURG, V58, P11, DOI 10.1016/j.ijsu.2018.08.009
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   Tottrup A, 2005, DIS COLON RECTUM, V48, P251, DOI 10.1007/s10350-004-0767-9
   Tsai YY, 2019, J GASTROINTEST ONCOL, V10, P1229, DOI 10.21037/jgo.2019.07.07
   Tschann P, 2022, LANGENBECK ARCH SURG, V407, P2945, DOI 10.1007/s00423-022-02609-2
   Tschann P, 2022, LANGENBECK ARCH SURG, V407, P1241, DOI 10.1007/s00423-021-02416-1
   UNDERWOOD JW, 1984, BRIT J SURG, V71, P209, DOI 10.1002/bjs.1800710314
   Vermeulen J, 2010, J GASTROINTEST SURG, V14, P651, DOI 10.1007/s11605-010-1155-5
   Vignali A, 2022, WORLD J GASTROENTERO, V28, P1394, DOI 10.3748/wjg.v28.i14.1394
   Wang GC, 2025, SCI REP-UK, V15, DOI 10.1038/s41598-025-03440-7
   Weber MC, 2023, LANGENBECK ARCH SURG, V408, DOI 10.1007/s00423-023-02809-4
   Wetterhall C, 2018, GASTROINTEST TUMORS, V5, P77, DOI 10.1159/000493526
   Willis MA, 2023, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD014909.pub2
   Yang JG, 2020, J SURG ONCOL, V121, P1283, DOI 10.1002/jso.25921
NR 33
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER WIEN
PI Vienna
PA Prinz-Eugen-Strasse 8-10, A-1040 Vienna, AUSTRIA
SN 1682-8631
EI 1682-4016
J9 EUR SURG
JI Eur. Surg.
PD 2026 MAR 6
PY 2026
DI 10.1007/s10353-026-00936-y
EA MAR 2026
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EX1FZ
UT WOS:001711824600001
DA 2026-07-24
ER
PT J
AU Okur, Ö
   Tabak, Z
   Can, M
   Boztas, AE
   Payza, AD
   Genisol, I
   Sencan, A
AF Okur, Ozkan
   Tabak, Zehra
   Can, Mehmet
   Boztas, Asya Eylem
   Payza, Ayse Demet
   Genisol, Incinur
   Sencan, Arzu
TI Negative pressure wound therapy in children: outcomes across a
   heterogeneous wound cohort
SO PEDIATRIC SURGERY INTERNATIONAL
LA English
DT Article
DE Negative-pressure wound therapy; Child; Wound healing; Surgical wound
   dehiscence; Burns
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; GAUZE; EXPERIENCE; INFANTS; TISSUE;
   FOAM
AB Purpose: Pediatric negative pressure wound therapy (NPWT) is widely used, but etiology- and age-informed real-world benchmarks are limited. We compared treatment burden and closure trajectories across pediatric wound categories. Methods: Retrospective single-center cohort of children (< 18 years) treated with NPWT for open wounds (2020-2025). Wounds were categorized as surgical (G1), acute (G2), chronic (G3), and burns (G4). NPWT was performed in accordance with an age-adapted institutional protocol in continuous mode; dressing changes were usually performed every 72 h. Results: 106 patients (median age 144 months, IQR 60-180) were included: G1 42, G2 22, G3 31, G4 11. Age distribution differed by group (p < 0.001), and instillation use varied (p = 0.014). Duration was longest in G3 (median 13 [8,-24] days) and shortest in G4 (median 6 [5,-9] days), while G1 and G2 were similar. Median cycle counts were similar across groups. Re-debridement was least frequent in G1. Definitive outcomes differed by etiology: primary closure predominated in G1, secondary healing in G3, and spontaneous closure in G4; grafting occurred mainly in burns, and flap reconstruction was rare. Conclusions: NPWT was feasible across heterogeneous pediatric wounds when used with a standardized, age-adapted approach. Etiology-specific differences in burden and outcomes inform expectations and support prospective multicenter evaluation.
C1 [Okur, Ozkan] Dr Behcet Uz Childrens Hosp, Pediat Surg, Ismet Kaptan Sokak, TR-35100 Konak, Izmir, Turkiye.
   [Tabak, Zehra; Can, Mehmet; Boztas, Asya Eylem; Payza, Ayse Demet; Genisol, Incinur] Univ Hlth Sci, Dr Behcet Uz Childrens Hosp, Pediat Surg, Izmir, Turkiye.
   [Sencan, Arzu] Univ Hlth Sci, Dr Behcet Uz Childrens Hosp, Izmir Fac Med, Pediat Surg, Izmir, Turkiye.
C3 Izmir Dr Behcet Uz Children's Disease & Surgery Training & Research
   Hospital; Izmir Dr Behcet Uz Children's Disease & Surgery Training &
   Research Hospital; University of Health Sciences Turkey; University of
   Health Sciences Turkey; Izmir Dr Behcet Uz Children's Disease & Surgery
   Training & Research Hospital
RP Okur, Ö (通讯作者)，Dr Behcet Uz Childrens Hosp, Pediat Surg, Ismet Kaptan Sokak, TR-35100 Konak, Izmir, Turkiye.
EM ozkanokurs@gmail.com; zehratabak8@gmail.com; mcan72@live.com;
   asyaeylem@gmail.com; demetpayza@gmail.com;
   imathncimathnurgenimathsol@msn.com; arzusencan71@yahoo.com.tr
RI sencan, arzu/HJJ-0979-2023; Okur, Özkan/AAV-7881-2021; CAN,
   MEHMET/AAV-7853-2021; genişol, incinur/HLG-2299-2023; BOZTAŞ, ASYA
   EYLEM/KIC-6267-2024
OI CAN, MEHMET/0000-0002-4263-0911; genişol, incinur/0000-0003-3843-5942;
   BOZTAŞ, ASYA EYLEM/0000-0002-5663-9394
CR Baharestani M, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00607.x
   Borgquist O, 2009, WOUNDS, V21, P302
   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   Crumley C, 2021, J WOUND OSTOMY CONT, V48, P195, DOI 10.1097/WON.0000000000000761
   de Jesus LE, 2018, J PEDIATR SURG, V53, P585, DOI 10.1016/j.jpedsurg.2017.11.048
   Elghandour MM, 2024, J PEDIATR SURG OPEN, V8, DOI 10.1016/j.yjpso.2024.100153
   Expert Working Group, 2008, Int Wound J, V5 Suppl 4, piii, DOI 10.1111/j.1742-481X.2008.00537.x
   Fraccalvieri M, 2011, INT WOUND J, V8, P355, DOI 10.1111/j.1742-481X.2011.00798.x
   Frear CC, 2019, TRIALS, V20, DOI 10.1186/s13063-019-3223-9
   Gupta S, 2016, INT WOUND J, V13, P159, DOI 10.1111/iwj.12452
   Hurd T, 2010, INT WOUND J, V7, P448, DOI 10.1111/j.1742-481X.2010.00714.x
   Iesalnieks I, 2021, LANGENBECK ARCH SURG, V406, P2569, DOI 10.1007/s00423-020-02060-1
   James K, 2024, AM J SURG, V228, P70, DOI 10.1016/j.amjsurg.2023.10.031
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Lopez G, 2008, J PEDIATR SURG, V43, P2202, DOI 10.1016/j.jpedsurg.2008.08.067
   Lou JQ, 2024, BMC PEDIATR, V24, DOI 10.1186/s12887-024-05302-z
   Lumsden E, 2023, PILOT FEASIBILITY ST, V9, DOI 10.1186/s40814-023-01308-z
   Lumsden EJ, 2023, BMJ OPEN, V13, DOI 10.1136/bmjopen-2022-068499
   McCord SS, 2007, WOUND REPAIR REGEN, V15, P296, DOI 10.1111/j.1524-475X.2007.00229.x
   McGarrah B, 2015, J WOUND OSTOMY CONT, V42, P409, DOI 10.1097/WON.0000000000000139
   Mustoe TA, 2006, PLAST RECONSTR SURG, V117, p35S, DOI 10.1097/01.prs.0000225431.63010.1b
   Nakagawa Y, 2022, BMC PEDIATR, V22, DOI 10.1186/s12887-022-03755-8
   Pauniaho SL, 2009, J PEDIATR SURG, V44, P1736, DOI 10.1016/j.jpedsurg.2009.01.009
   Pedrazzi NE, 2021, ADV WOUND CARE, V10, P270, DOI 10.1089/wound.2019.1089
   Ren YH, 2017, INT J BURNS TRAUMA, V7, P12
   Rentea RM, 2013, J SURG RES, V184, P658, DOI 10.1016/j.jss.2013.05.056
   Stoffan AP, 2012, J PEDIATR SURG, V47, P1555, DOI 10.1016/j.jpedsurg.2012.01.014
   Thanh Tri T, 2021, Clin Ter, V172, P273, DOI 10.7417/CT.2021.2331
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
NR 30
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-0358
EI 1437-9813
J9 PEDIATR SURG INT
JI Pediatr. Surg. Int.
PD MAR 6
PY 2026
VL 42
IS 1
AR 141
DI 10.1007/s00383-026-06370-1
PG 9
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA EX1WQ
UT WOS:001711868000003
PM 41790251
DA 2026-07-24
ER
PT J
AU Vidiscák, M
   Hajská, M
   Dubovsky, M
   Peter, Z
   Panyko, A
AF Vidiscak, Marian
   Hajska, Marianna
   Dubovsky, Martin
   Peter, Zahorec
   Panyko, Arpad
TI Negative Pressure Wound Therapy with Instillation in Polymorbid Surgical
   Patients: A Retrospective Single-Centre Analysis
SO BRATISLAVA MEDICAL JOURNAL
LA English
DT Article
DE Negative pressure; Instillation; Efficacy; Wound treatment
ID RECOMMENDATIONS
AB BackgroundNegative pressure wound therapy with instillation (NPWTi) represents an advanced wound management modality that combines the mechanical effects of negative pressure with cyclic instillation of topical solutions. Although its efficacy has been demonstrated in selected indications, clinical experience from general surgery departments remains limited.AimTo describe clinical experience with NPWTi in a general surgery setting, assess its effectiveness, and evaluate the potential association between treatment failure and patient multimorbidity.MethodsA retrospective single-centre analysis was conducted in 15 adult patients treated with NPWTi between 2021 and 2025. NPWTi was applied using the 3M (TM) V.A.C. Ulta Therapy Unit with four instillation cycles per day and a 15-min dwell time, employing an electrochemically activated mineral salt solution. Demographic data, wound characteristics, treatment parameters, comorbidities, and laboratory markers were analysed. Treatment was assessed as successful, in the case of wound cleanse and healing promotion, that enabled subsequent wound reconstruction, all other outcomes were classified as failure. Associations between treatment outcomes and comorbidities, including multimorbidity, were evaluated by statistical analysis.ResultsThe mean patient age was 64.3 +/- 13.5 years. Overall treatment success was achieved in 11 patients (73%), while treatment failure occurred in 4 patients (27%). NPWTi was most used for abscesses, postoperative wound dehiscence, and diabetic foot syndrome with gangrene. Cardiovascular disease, diabetes mellitus, and obesity were highly prevalent. Multimorbidity was present in 14 patients. No statistically significant association was observed between multimorbidity and NPWTi treatment outcome (p = 1.00).ConclusionIn this cohort of predominantly elderly and polymorbid patients, NPWTi demonstrated a high success rate and appeared effective across a broad spectrum of complex surgical wounds. These findings support NPWTi as a valuable adjunctive therapy in high-risk patient populations, although larger prospective studies are required to further define its role and optimal indications.
C1 [Vidiscak, Marian; Hajska, Marianna; Dubovsky, Martin; Panyko, Arpad] Comenius Univ, Fac Med, Dept Surg 4, Bratislava, Slovakia.
   [Peter, Zahorec] Comenius Univ, Fac Med, Dept Burns & Reconstruct Surg, Bratislava, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava
RP Hajská, M (通讯作者)，Comenius Univ, Fac Med, Dept Surg 4, Bratislava, Slovakia.
EM marianna.hajska@fmed.uniba.sk
RI Panyko, Arpád/AAQ-6309-2020; Vidiscak, Marian/AAZ-6765-2021
OI Hajská, Marianna/0000-0002-0822-8929
FU Comenius University in Bratislava
FX Open access funding provided by The Ministry of Education, Science,
   Research and Sport of the Slovak Republic in cooperation with Centre for
   Scientific and Technical Information of the Slovak Republic
CR Acosta S., 2025, INT WOUND J, V22, DOI 10.1111/iwj.70791
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   Back DA, 2013, INT WOUND J, V10, P32, DOI 10.1111/iwj.12183
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   Dalla Paola L, 2013, INT WOUND J, V10, P25, DOI 10.1111/iwj.12174
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   Hudson DA., 2024, INT WOUND J, V22, DOI 10.1111/iwj.70750
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   Kim PJ., 2020, WOUNDS, V32, pS1
   Lee Gordon, 2020, Wounds, V32, pE76
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   Zhou LR, 2025, FRONT ONCOL, V15, DOI 10.3389/fonc.2025.1644593
NR 21
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PD MAY
PY 2026
VL 127
IS 5
BP 1949
EP 1955
DI 10.1007/s44411-026-00569-3
EA MAR 2026
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GQ9TD
UT WOS:001712571400001
OA gold
DA 2026-07-24
ER
PT J
AU Raab, S
   Girdauskas, E
   Reindl, S
AF Raab, Stephan
   Girdauskas, Evaldas
   Reindl, Sebastian
TI Treatment of the infection in deep sternal wound infections-a single
   center cohort study
SO JOURNAL OF THORACIC DISEASE
LA English
DT Article
DE Deep sternal wound infection (DSWI); negative pressure wound therapy
   (NPWT); sternum osteomyelitis
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY
AB Background: In the treatment of deep sternal wound infections (DSWIs) using negative pressure wound therapy (NPWT), infection therapy is separated from reconstruction of the thoracic wall. It is difficult to decide when NPWT can end in order to close the wound. Often ideal conditions cannot be achieved. Must or can sterility be waited for and should antibiotics be administered and if so for how long? These questions are discussed here. Methods: A retrospective single center analysis is performed. Patients who developed a DSWI after cardiac surgery between 2014 and 2020 are included. The following parameters are collected: baseline data, number of negative pressure dressing changes, frequency of persistence of infection and antibacterial therapy performed at closure. Either a short-term antibiotic therapy over 5 days or a therapy corresponding to the osteomyelitis treatment over 6 weeks was carried out. Results: In 79 patients, sterility was achieved after 10.2 +/- 3.9 (mean +/- standard deviation) changes of the negative pressure dressing using NPWT. In 51 patients, NPWT was terminated after 7.4 +/- 5.3 changes without achieving sterility. The number of changes varied significantly. If sterility could be achieved, the frequency of infection complications was significantly lower. Long-term antibiotic therapy resulted in significantly fewer infections than short-term therapy. Conclusions: Microbiological sterility should be achieved if possible. This requires more dressing changes, but the complications are rarer. If it is not possible to wait for sterility, long-term antibiotic therapy is required if osteomyelitis occurs.
C1 [Raab, Stephan; Girdauskas, Evaldas; Reindl, Sebastian] Univ Augsburg, Univ Hosp Augsburg, Fac Med, Clin Cardiothorac Surg, Stenglinstr 2, D-86156 Augsburg, Germany.
C3 University of Augsburg
RP Reindl, S (通讯作者)，Univ Augsburg, Univ Hosp Augsburg, Fac Med, Clin Cardiothorac Surg, Stenglinstr 2, D-86156 Augsburg, Germany.
EM sebastian.reindl@uk-augsburg.de
RI Girdauskas, Evaldas/AAE-7771-2020; Raab, Stephan/OOL-1792-2025
OI Girdauskas, Evaldas/0000-0003-1571-4244; 
CR Assmann A, 2011, THORAC CARDIOV SURG, V59, P25, DOI 10.1055/s-0030-1250598
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   Chan M, 2016, DIAGN MICR INFEC DIS, V84, P261, DOI 10.1016/j.diagmicrobio.2015.11.011
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   German Society for Thoracic and Cardiovascular Surgery (DGTHG) German Society for Hygiene and Microbiology German Society for Infectious Diseases, 2019, THORAC CARDIOV SURG, V67, pS1
   Khanlari B, 2010, J ANTIMICROB CHEMOTH, V65, P1799, DOI 10.1093/jac/dkq182
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   Risnes I, 2014, INT WOUND J, V11, P177, DOI 10.1111/j.1742-481X.2012.01060.x
   Saltarocchi S, 2023, WOUNDS, V35, pE63, DOI 10.25270/wnds/21141
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
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NR 19
TC 0
Z9 0
U1 0
U2 0
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2072-1439
EI 2077-6624
J9 J THORAC DIS
JI J. Thorac. Dis.
PD FEB 28
PY 2026
VL 18
IS 2
AR 137
DI 10.21037/jtd-2025-aw-2201
PG 8
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA EY6IL
UT WOS:001712849100030
PM 41816370
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Egin, S
AF Egin, Seracettin
TI A new scoring system for the prediction of mortality in Fournier's
   gangrene: The Egin score
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Fournier's gangrene; Fournier's Gangrene Severity Index; Uludag
   Fournier's Gangrene Severity Index; mortality; vacuum-assisted closure
ID OUTCOME PREDICTION; THERAPY
AB BACKGROUND: This study aimed to investigate the factors affecting mortality in Fournier's gangrene (FG) and to establish a simplified scoring system that enables practical bedside assessment for clinicians. METHODS: The medical records of 130 patients treated for FG between February 2012 and January 2025 were retrospectively reviewed. Survivors (Group 1, n=101) were analyzed separately from non-survivors (Group 2, n=29). The collected data included sex, source of infection, presence of diabetes mellitus (DM), obesity, and other comorbidities. Additional variables included the presence of a diverting stoma, duration of vacuum-assisted closure (VAC) therapy, length of hospital stay, intensive care period (ICP), and isolated bacterial species. Associations between mortality and factors such as age, infection spread score, comorbidities other than DM and obesity (CADO), and ICP were examined. RESULTS: A significant difference was observed between the groups in terms of age and age score. The infection spread score was significantly higher in Group 2. While 60 patients in Group 1 had CADO, all patients in Group 2 had CADO, demonstrating a statistically significant difference. ICP was also significantly longer among non-survivors. Receiver operating characteristic (ROC) analysis demonstrated that the Egin score had a sensitivity of 96.6% and a specificity of 63.4% at a threshold value of >3. CONCLUSION: Age, infection spread score, CADO, and ICP, which constitute the Egin score, demonstrated significant differences between survivors and non-survivors. These parameters are crucial for predicting mortality in patients with FG.
C1 [Egin, Seracettin] Univ Hlth Sci, Istanbul Prof Dr Cemil Tascioglu City Hosp, Dept Gen Surg, Istanbul, Turkiye.
C3 University of Health Sciences Turkey
RP Egin, S (通讯作者)，Univ Hlth Sci, Istanbul Prof Dr Cemil Tascioglu City Hosp, Dept Gen Surg, Istanbul, Turkiye.
EM seracettin_egin@hotmail.com
RI Eğin, Seracettin/GQZ-0908-2022
OI Eğin, Seracettin/0000-0002-4090-5205
CR Çomçali B, 2022, ULUS TRAVMA ACIL CER, V28, P490, DOI 10.14744/tjtes.2020.68137
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   Yilmazlar T, 2014, ULUS TRAVMA ACIL CER, V20, P333, DOI 10.5505/tjtes.2014.06870
NR 17
TC 0
Z9 0
U1 0
U2 0
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, Turkiye
SN 1306-696X
EI 1307-7945
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD MAR
PY 2026
VL 32
IS 3
BP 270
EP 278
DI 10.14744/tjtes.2025.55901
PG 9
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA FA3PG
UT WOS:001714019100006
PM 41992996
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Andrews, E
   Bruwer, F
   Goosen, J
   Kairinos, N
   Laher, S
   Moeng, MS
   Ngcakani, A
   Ramdial, S
   Vadia, S
   Van Wyk, J
   Viljoen, JJ
   Weyers, DW
   Trivedi, S
AF Andrews, Ethel
   Bruwer, Febe
   Goosen, Jacques
   Kairinos, Nick
   Laher, Saadia
   Moeng, Maeyane S.
   Ngcakani, Anati
   Ramdial, Shaal
   Vadia, Suleman
   Van Wyk, Jacques
   Viljoen, Jacobus Jg
   Weyers, Deon W.
   Trivedi, Sadhana
TI Negative pressure wound therapy use: recommendations from a South
   African panel of experts
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE closed incision negative pressure therapy; negative pressure wound
   therapy; with instillation; panel recommendations; South Africa; wound;
   wound care; wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; HIGH-RISK PATIENTS; CARE; INSTILLATION;
   METAANALYSIS; COMORBIDITIES; COMPLICATIONS; PREVALENCE; DRESSINGS;
   STANDARD
AB Objective: The South African patient population is complex, with elevated traumatic injury rates and individuals living with multiple comorbidities. Healthcare provider and funding shortages, as well as wound care training not being a recognised subspecialty, have added to the burden of an already pressured South African healthcare system. With increases in non-specialist clinicians providing wound care, South Africa-specific wound care guidelines are needed. Method: An in-person meeting was held with wound care experts across South Africa to develop treatment recommendations for the use of negative pressure wound therapy (NPWT)-based systems. The publication panel convened on 8-9 December 2023 in Johannesburg, South Africa. The group of 14 panel members, including surgeons, wound care nurses and nurse practitioners, discussed clinical evidence regarding NPWT-based system use, followed by the development of a therapy-use algorithm. Results: Panel members recommended NPWT use for both simple/ low-risk and complex/large/high-risk wounds. NPWT with instillation and dwell time was recommended for both simple and complex wounds requiring cleansing. NPWT or closed incision negative pressure therapy use was recommended, as needed, following wound closure as per the reconstructive ladder. Conclusion: Limited published evidence supporting the use of NPWT-based systems exists for South Africa. These panel recommendations are a starting point and should be revised as more clinical evidence on NPWT-based system use within South Africa is published.
C1 [Andrews, Ethel] Univ Witwatersrand, Nursing Educ, Johannesburg, South Africa.
   [Bruwer, Febe] Life Roseacres Hosp, Adv Wound Care, Germiston, South Africa.
   [Goosen, Jacques; Moeng, Maeyane S.] Univ Witwatersrand, Sch Clin Med, Trauma Surg, Johannesburg, South Africa.
   [Goosen, Jacques] Netcare Alberton Hosp, Trauma Surg, Alberton, South Africa.
   [Kairinos, Nick] Univ Stellenbosch, Plast & Reconstruct Surg, Stellenbosch, South Africa.
   [Laher, Saadia] Netcare Alberton Hosp, Plast & Reconstruct Surg, Alberton, South Africa.
   [Laher, Saadia] Midvaal Hosp, Plast & Reconstruct Surg, Johannesburg, South Africa.
   [Ngcakani, Anati] Edenvale Gen Hosp, Orthopaed, Edenvale, South Africa.
   [Ramdial, Shaal] Life Entabeni Hosp, Plast & Reconstruct Surg, Berea, South Africa.
   [Ramdial, Shaal] Life Crompton Hosp, Plast & Reconstruct Surg, Pinetown, South Africa.
   [Vadia, Suleman] Netcare Milpark & Rosebank Hosp, Plast Reconstruct & Cosmet Surg, Johannesburg, South Africa.
   [Van Wyk, Jacques] Mediclin Panorama, Cardiothorac Surg, Cape Town, South Africa.
   [Viljoen, Jacobus Jg] Steve Biko Acad Hosp, Orthopaed, Pretoria, South Africa.
   [Weyers, Deon W.] Life Fourways Hosp, Plast & Reconstruct Surg, Johannesburg, South Africa.
   [Trivedi, Sadhana] Solventum, Med Surg, Dublin, Ireland.
C3 University of Witwatersrand; University of Witwatersrand; Stellenbosch
   University; University of Pretoria; Steve Biko Academy Hospital
RP Trivedi, S (通讯作者)，Solventum, Med Surg, Dublin, Ireland.
EM strivedi2@solventum.com
RI Moeng, Maeyane/OPN-3614-2025; Bruwer, Febe Antoinette/MTC-0199-2025
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NR 71
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2026
VL 35
IS 3
BP 221
EP 228
DI 10.12968/jowc.2025.0219
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FA9ZG
UT WOS:001714450700001
PM 41805436
DA 2026-07-24
ER
PT J
AU Thomas, JR
   Crystal, DT
   Patel, SD
   Kim, J
   Habarth-Morales, TE
   Broach, RB
   Kanchwala, SK
   Azoury, SC
AF Thomas, Jacob R.
   Crystal, Dustin T.
   Patel, Shiv D.
   Kim, Jusung
   Habarth-Morales, Theodore E.
   Broach, Robyn B.
   Kanchwala, Suhail K.
   Azoury, Said C.
TI Negative Pressure Wound Therapy and Donor Site Morbidity in DIEP and
   Tram Flap Reconstruction: A Single-Center Longitudinal Review
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Review; Early Access
DE negative pressure wound therapy; incisional wound vac; DIEP flap; TRAM
   flap; autologous breast reconstruction; abdominal morbidity
ID BREAST RECONSTRUCTION; COMPLICATIONS; SMOKING; IMPACT; MANAGEMENT
AB Background Abdominally based breast free flap reconstruction exposes patients to potential significant donor site morbidity. Utilization of postoperative Incisional Negative Pressure Wound Therapy (iNPWT) has been proposed to minimize incision site complications. This study aims to assess if iNPWT reduces rates of donor site complications after DIEP and TRAM flap harvest. Methods This single-center, retrospective study included patients who underwent Deep Inferior Epigastric Artery (DIEP) or Transverse Rectus Abdominis Muscle (TRAM) flap reconstruction from 2022 to 2024. Patients' abdominal donor sites received either standard wound care or iNPWT at the time of reconstruction. Results A total of 362 patients were identified with a median age of 51.3 (IQR: 43.3-59.6) years. Rates of delayed healing at the donor site were lower in the iNPWT cohort compared to standard of care (13.4% vs. 35.3%, p < 0.001). Controlling for tobacco exposure, diabetes, hypertension, and laterality, there was a lower likelihood of delayed healing in the iNPWT cohort (OR: 0.249 [0.14-0.43], p < 0.001). This finding persisted in current and former smokers (OR: 0.269 [0.16-0.46], p < 0.001) and patients with comorbid hypertension (OR: 0.257 [0.15-0.44], p < 0.001). Conclusion These results suggest iNPWT usage is associated with lower rates of donor site delayed healing after DIEP and TRAM procedures in the general patient population and should be considered in those with two or more vascular risk factors. Further investigation is required to stratify the risk of delayed healing for patients with concomitant hypertension, tobacco exposure, diabetes, and/or obesity.
C1 [Thomas, Jacob R.; Crystal, Dustin T.; Patel, Shiv D.; Kim, Jusung; Habarth-Morales, Theodore E.; Broach, Robyn B.; Kanchwala, Suhail K.; Azoury, Said C.] Univ Penn, Dept Surg, Div Plast Surg, Philadelphia, PA USA.
   [Thomas, Jacob R.; Patel, Shiv D.; Kim, Jusung] Univ Penn, Perelman Sch Med, Philadelphia, PA USA.
C3 University of Pennsylvania; University of Pennsylvania
RP Azoury, SC (通讯作者)，Univ Penn, Perelman Ctr Adv Med, 3400 Civ Ctr Blvd,14th Floor,South Bldg, Philadelphia, PA 19104 USA.
EM Said.azoury@pennmedicine.upenn.edu
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD 2026 MAR 13
PY 2026
DI 10.1055/a-2824-6484
EA MAR 2026
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FB2JR
UT WOS:001714613000001
PM 41776943
DA 2026-07-24
ER
PT J
AU Ding, S
   Gong, Y
   Song, MM
   Guo, ZW
   Sun, R
   Liu, YF
   Ge, ZL
AF Ding, Sheng
   Gong, Yin
   Song, Mingming
   Guo, Zaiwen
   Sun, Ran
   Liu, Yunfeng
   Ge, Zili
TI Factors associated with the prognosis of diabetic foot ulcers treated
   with silver ion hydrogel dressings combined with negative pressure wound
   therapy and the construction of a risk prediction model: a study of two
   machine learning methods, LASSO and random forest algorithms
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article; Early Access
DE Diabetic foot ulcer; Silver ion hydrogel; Negative pressure wound
   therapy; Risk prediction model
AB BackgroundDiabetic foot ulcers (DFUs) represent a serious chronic complication of diabetes, with substantial morbidity and healthcare costs. Despite advances in treatment modalities such as silver ion hydrogel dressings combined with negative pressure wound therapy (NPWT), clinical outcomes remain highly heterogeneous. Identifying prognostic factors and developing accurate risk prediction tools are essential for personalized management and improved patient outcomes.<br /> ObjectiveThe objective of this study was to identify key prognostic factors in DFU patients undergoing combined silver ion hydrogel and NPWT therapy and to develop a validated risk prediction model.<br /> MethodsThis retrospective study analyzed 200 DFU patients admitted to our hospital between March 2023 and December 2024. Data were extracted from the electronic medical record system, and patients were stratified into good and poor prognosis groups according to clinical outcomes. After collection and comparison of clinical variables, two machine learning approaches-LASSO regression and random forest (RF)-were employed to identify risk factors using an "overlapping selection" strategy. Significant predictors were further assessed by multivariate logistic analysis. A predictive model was subsequently developed and validated using R software.<br /> ResultsA total of 200 DFU patients were included in the analysis. Based on electronic medical records, 49 patients (24.50%) were classified into the poor prognosis group, while 151 patients (75.50%) comprised the good prognosis group. Significant differences (p < 0.05) were observed between the two groups in several clinical parameters: number of ulcers, ulcer area, interleukin-17 (IL-17) levels, Th1 cell count, Th2 cell count, procalcitonin (PCT), and C-reactive protein (CRP) levels. Using two machine learning methods-LASSO regression and the random forest (RF) algorithm-different sets of risk factors were screened. By applying an "overlap coverage" approach, five common risk factors for DFU prognosis were identified: IL-17, Th1 cells, Th2 cells, PCT, and CRP. These were included in the logistic regression model. The results indicated that IL-17, Th1 cells, PCT, and CRP were all risk factors for poor prognosis in DFU patients (OR = 1.275, 1.411, 1.006, and 1.101, respectively, p < 0.05), while Th2 cells were a protective factor for poor prognosis in DFU patients (OR = 0.001, p < 0.05). Based on the results of the logistic regression analysis, a risk prediction model for the prognosis of DFU patients was constructed using a nomogram. The ROC curve showed an AUC value of 0.937, with a 95% CI of 0.887 to 0.986. The calibration curve indicated that the model's predicted results were well aligned with the actual prognosis of DFU patients. The Cox-Snell R2 was 0.675, Nagelkerke R2 0.454, Brier Score 0.067, model fit p-value 0, and statistic 33.491. The clinical decision curve was generally above the two extreme curves, indicating that the factors included in the nomogram have a high net benefit for predicting the prognosis of DFU patients.<br /> ConclusionThere are numerous factors influencing the prognosis of DFU patients, primarily including IL-17, Th1 cells, Th2 cells, PCT, and CRP. The risk prediction nomogram model constructed based on these factors demonstrates good predictive performance for the risk of adverse outcomes in DFU patients and shows potential for clinical application in identifying high-risk individuals for targeted management strategies.
   Clinicians should identify high-risk populations early and optimize treatment strategies accordingly to improve outcomes.
C1 [Ding, Sheng; Gong, Yin; Ge, Zili] Soochow Univ, Affiliated Hosp 1, Dept Stomatol, 188 Shizi St, Suzhou City 215002, Jiangsu Provin, Peoples R China.
   [Ding, Sheng; Song, Mingming; Guo, Zaiwen; Sun, Ran; Liu, Yunfeng] Nanjing Med Univ, Suzhou Municipal Hosp, Dept Burns & Plast Surg, Affiliated Suzhou Hosp, Suzhou 215002, Jiangsu Provinc, Peoples R China.
C3 Soochow University - China; Nanjing Medical University
RP Ge, ZL (通讯作者)，Soochow Univ, Affiliated Hosp 1, Dept Stomatol, 188 Shizi St, Suzhou City 215002, Jiangsu Provin, Peoples R China.
EM dingsheng0703@163.com
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NR 32
TC 1
Z9 2
U1 1
U2 1
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD 2026 MAR 13
PY 2026
DI 10.1007/s13410-026-01636-9
EA MAR 2026
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FB3GS
UT WOS:001714673200001
DA 2026-07-24
ER
PT J
AU Cottom, JM
   Verdoni, TJ
AF Cottom, James M.
   Verdoni, Tyler J.
TI Evaluation of incisional negative pressure wound therapy with anterior
   approach total ankle arthroplasty
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE Ankle replacement; Incision healing; Wound vac
ID SURGICAL INCISION; COMPLICATIONS; CLASSIFICATION; MANAGEMENT; SURGERY;
   HIP
AB Background: Total ankle replacement continues to find significantly increased utilization as the technology advances. While there are different systems on the market, most are implanted through an anterior incisional approach just lateral to the tibialis anterior tendon. This incision is prone to decreased wound healing, increased time to healing, and postoperative dehiscence and infection risk. When patient comorbid medical conditions are taken into consideration as well, the chance of complications increases significantly. To date, multiple articles have been published discussing how to decrease complication rate associated with this higher risk incision, such as different suturing patterns, utilization of a postoperative drain, and incisional wound vac application (iNPWT). Purpose: The purpose of this study is to present our results with iNPWT utilization for anterior approach total ankle arthroplasty. Methods: Thirty one (31) patient's consecutive total ankle replacement (TARs) were retrospectively reviewed. Eleven [11] patients underwent TAR with iNPWT (Group 1) application and 20 patients underwent TAR without iNPWT (Group 2) application. Results: In group 1, wound complications were 1/11 (9 %) and in group 2 wound complications were 4/20(20 %); with an overall 5/31 (16%) wound complication rate (p value 0.429). Conclusion: In our present study, we identified a reduction of wound healing complications by 11 % when comparing the two groups, although failed to reach statistical significance. While future studies are needed with more patient enrollment, iNPWT application is a quick and safe method to help reduce complications associated with the anterior approach for total ankle replacement. (c) 2025 by the American College of Foot and Ankle Surgeons. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Cottom, James M.; Verdoni, Tyler J.] Florida Orthoped Foot & Ankle Ctr, Modern Foot & Ankle, 5741 Bee Ridge Rd,Suite 490, Sarasota, FL 34233 USA.
RP Cottom, JM (通讯作者)，Florida Orthoped Foot & Ankle Ctr, Modern Foot & Ankle, 5741 Bee Ridge Rd,Suite 490, Sarasota, FL 34233 USA.
EM Jamescottom300@hotmail.com
CR [Anonymous], 2000, J ARTHROPLASTY, V36, P2402
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAR-APR
PY 2026
VL 65
IS 2
BP 60e1
EP 60e5
DI 10.1053/j.jfas.2025.11.010
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA FE1GR
UT WOS:001716575400001
PM 41242546
DA 2026-07-24
ER
PT J
AU Dong, YC
   Zhang, YH
   Lin, ZX
   Li, XY
   Guo, Z
   Li, T
   Ma, FX
   Li, J
AF Dong, Yuchen
   Zhang, Yuheng
   Lin, Zhixiao
   Li, Xueyong
   Guo, Zheng
   Li, Tian
   Ma, Fuxin
   Li, Jing
TI Negative pressure mechanical signal increases the phosphorylation of
   eNOS Ser1177 by upregulating HSP90 expression to promote wound
   angiogenesis
SO JOURNAL OF ADVANCED RESEARCH
LA English
DT Article
DE Mechanical stretching; Chronic wound; Angiogenesis; Single-cell
   sequencing; eNOS
ID VACUUM-ASSISTED CLOSURE; NITRIC-OXIDE SYNTHASE; THERAPY; PROLIFERATION;
   MEDIASTINITIS; MODALITIES; MANAGEMENT; SURGERY; CELLS; NPWT
AB Background: Chronic wound wound therapy (NPWT) clinic Methods: A mechanical stretching model simulating NPWT was established in vitro. Multiomics approaches (single-cell seque HSP90-related regulatory networks. Typical molecular biological techniques are used to detect the expression of relevant proteins. Mor Results: NPWT-induced mech pathogenesis involves impaired angiogenesis. While negative pressure ally promotes angiogenesis, its biomechanical mechanisms remain unclear. ncing, Ch-IP, Co-IP, and molecular docking) were employed to dissect eover, a rat dorsal wound model was used for the animal experiments. anical stimulation activates the GNAS/CREB1/HSP90 axis, increasing HSP90 transcription via CREB1 nuclea phosphorylation, driving angi of GNAS/CREB1 suppresses HS Conclusion: This study reveals a GNAS-mediated mechanotransduction pathway that activates HSP90-dependent eNOS signaling to accelerate wound angiogenesis, suggesting novel targets for therapeutic intervention. (c) 2025 The Authors. Publishe r translocation. Elevated HSP90 displaces Cav-1 to augment eNOS Ser1177 ogenesis to promote wound healing. Pharmacological or genetic disruption P90 expression and angiogenic capacity. d by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Dong, Yuchen; Li, Xueyong; Li, Tian; Ma, Fuxin; Li, Jing] Fourth Mil Med Univ, Tangdu Hosp, Dept Plast & Burn Surg, Xian 710038, Peoples R China.
   [Zhang, Yuheng; Guo, Zheng] Fourth Mil Med Univ, Tangdu Hosp, Dept Orthoped, Xian 710038, Peoples R China.
   [Zhang, Yuheng] Western Theater Air Force Hosp PLA, Dept Orthoped, Chengdu 610011, Peoples R China.
   [Lin, Zhixiao] 923 Hosp Joint Logist Support Force PLA, Dept Burn & Plast Surg, Nanning 530022, Peoples R China.
   [Li, Tian] Tianjin Med Univ, Tianjin Nankai Hosp, Inst Integrat Med Acute Abdominal Dis, Tianjin Key Lab Acute Abdomen Dis Associated Organ, Tianjin 300100, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Tianjin
   Medical University
RP Li, T; Ma, FX; Li, J (通讯作者)，Fourth Mil Med Univ, Tangdu Hosp, Dept Plast & Burn Surg, Xian 710038, Peoples R China.; Li, T (通讯作者)，Tianjin Med Univ, Tianjin Nankai Hosp, Inst Integrat Med Acute Abdominal Dis, Tianjin Key Lab Acute Abdomen Dis Associated Organ, Tianjin 300100, Peoples R China.
EM fmmult@foxmail.com; mfx1341@163.com; lijing02@fmmu.edu.cn
RI Li, Tian/ADZ-3422-2022
FU Key Research and Development Projects of Shaanxi Province
   [2022ZDLSF04-03]
FX This work was supported by the Key Research and Development Projects of
   Shaanxi Province (2022ZDLSF04-03) .
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NR 69
TC 2
Z9 2
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2090-1232
EI 2090-1224
J9 J ADV RES
JI J. Adv. Res.
PD APR
PY 2026
VL 82
BP 1011
EP 1026
DI 10.1016/j.jare.2025.07.041
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FF9OY
UT WOS:001717823100001
PM 40721022
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jia, Z
   Yu, B
   Jiang, D
   Chang, ZQ
   Wan, SY
AF Jia, Zhen
   Yu, Bo
   Jiang, Di
   Chang, Zhengqi
   Wan, Shiyong
TI Case Report: A rare but critical complication in patients with lumbar
   infection combined with cauda equina syndrome-sacrococcygeal pressure
   sores
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE cauda equina syndrome; complication prevention; lumbar spine infection;
   pressure injury; pressure sore; Vacuum Sealing Drainage
ID WOUND THERAPY; ABSCESS
AB This report presents a complex case of a 65-year-old male patient with a lumbar spine infection (T12-L1) caused by Staphylococcus aureus, leading to cauda equina syndrome, and subsequently developing a massive infectious pressure sore in the sacrococcygeal region. Back pain due to spinal infections, analgesic use, neurological deficits, and systemic infections masked the early signs of the pressure sore. Prolonged immobilization and neurogenic bladder and bowel incontinence led to a 5 cm & times; 5 cm deep pressure sore in the sacrococcygeal area. Involving a single-stage surgery for debriding the spinal lesion and performing internal fixation, along with debriding the sacrococcygeal ulcer using Vacuum Sealing Drainage (VSD) in both infected areas, this treatment not only aids in infection control but also reduces the overall treatment duration. Through multiple VSD changes, antimicrobial therapy, and nutritional support, the spinal infection was cured, and the pressure sore wound healed. This case underscores the importance of early prevention and identification of sacrococcygeal ulcers in patients with lumbar spine infections and neurological deficits to prevent the occurrence and progression of this severe complication.
C1 [Jia, Zhen; Yu, Bo; Jiang, Di; Wan, Shiyong] 961th Hosp PLA, Dept Orthoped, Qiqihar, Peoples R China.
   [Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
RP Wan, SY (通讯作者)，961th Hosp PLA, Dept Orthoped, Qiqihar, Peoples R China.; Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
EM 26766771@qq.com; wanshiyong961@163.com
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 6
PY 2026
VL 13
AR 1776438
DI 10.3389/fmed.2026.1776438
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FH5IQ
UT WOS:001718895300001
PM 41868212
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kitaguchi, D
   Forgione, A
   Innocenzi, C
   Yang, YC
   Espínola, F
   Giménez, M
   Oda, T
   Marescaux, J
AF Kitaguchi, Daichi
   Forgione, Antonello
   Innocenzi, Chiara
   Yang, Yuchuan
   Espinola, Federico
   Gimenez, Mariano
   Oda, Tatsuya
   Marescaux, Jacques
TI A systematic review and Bayesian network meta-analysis of randomized
   controlled trials on multiple skin closure techniques following stoma
   closure
SO COLORECTAL DISEASE
LA English
DT Review
DE network meta-analysis; stoma closure; surgical stomas; surgical wound
   infection; wound healing
ID SURGICAL SITE INFECTION; CARE-ASSOCIATED INFECTIONS; PRESSURE WOUND
   THERAPY; CLINICAL-TRIAL; CONVENTIONAL CLOSURE; ILEOSTOMY CLOSURE;
   REVERSAL; APPROXIMATION; PREVENTION; OUTCOMES
AB Background: Surgical site infection (SSI) is one of the most frequent complications after stoma closure. It is associated with prolonged recovery, increased healthcare costs and impaired quality of life. Several skin closure techniques have been proposed to reduce SSI. However, most previous studies relied on pairwise comparisons, leaving uncertainty about the relative effectiveness of different approaches. This study aimed to compare skin closure methods after stoma closure using a systematic review and Bayesian network meta-analysis. Methods: MEDLINE (PubMed), Embase and the Cochrane Library were searched. A total of 23 randomized controlled trials enrolling 1851 adult patients who underwent stoma closure were included. Skin closure methods included linear closure, purse-string closure and gunsight closure, with or without negative pressure wound therapy or a subcutaneous drain. The primary outcome was SSI. Secondary outcomes were length of hospital stay and time to complete wound healing. Results: Across all studies, purse-string closure was associated with a markedly lower incidence of SSI as compared to linear closure (risk ratio: 0.18, 95% credible intervals: 0.07-0.37). No significant differences were observed between groups regarding hospital stay. However, wound healing was generally slower after purse-string closure, ranking lowest among evaluated techniques in time to complete wound healing. The overall certainty of evidence was moderate, and results were consistent across sensitivity analyses. Conclusions: Purse-string closure is likely to be associated with the lowest risk of SSI after stoma closure. However, it may be associated with delayed wound healing. Consequently, further refinement of this technique or the development of combination strategies is necessary to optimize both infection prevention and wound-healing outcomes.
C1 [Kitaguchi, Daichi; Forgione, Antonello; Innocenzi, Chiara; Yang, Yuchuan; Espinola, Federico; Gimenez, Mariano; Marescaux, Jacques] Res Inst Digest Canc IRCAD, Strasbourg, France.
   [Kitaguchi, Daichi; Oda, Tatsuya] Univ Tsukuba, Inst Med, Dept Gastrointestinal Hepatobiliary Pancreat Surg, Tsukuba, Ibaraki, Japan.
   [Innocenzi, Chiara] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Women Children & Publ Hlth Sci, Rome, Italy.
C3 University of Tsukuba; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli
RP Forgione, A (通讯作者)，Res Inst Digest Canc IRCAD, Strasbourg, France.
EM antonello.forgione@ircad.fr
RI ; Innocenzi, Chiara/QLV-8592-2026
OI Kitaguchi, Daichi/0000-0002-8197-6317; 
FU Japan Agency for Medical Research and Development [JP256f0137008]
FX This research was partially supported by AMED under Grant Number
   JP256f0137008.
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NR 49
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD MAR
PY 2026
VL 28
IS 3
AR e70412
DI 10.1111/codi.70412
PG 11
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA FJ1GA
UT WOS:001719973800007
PM 41786646
DA 2026-07-24
ER
PT J
AU Yamashiro, T
   Kushibiki, T
   Mayumi, Y
   Tsuchiya, M
   Ishihara, M
   Azuma, R
AF Yamashiro, Toshifumi
   Kushibiki, Toshihiro
   Mayumi, Yoshine
   Tsuchiya, Masato
   Ishihara, Miya
   Azuma, Ryuichi
TI Negative-Pressure Induces Epithelial-Mesenchymal Transition via
   Thrombospondin-1 Upregulation in Intact Diabetic Skin
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE diabetic skin; epithelial-mesenchymal transition; keratinocytes;
   negative-pressure wound therapy; thrombospondin-1; wound remodelling
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; SERPINE1 PAI-1;
   MECHANOTRANSDUCTION; KERATINOCYTES; METAANALYSIS; EXPRESSION; MIGRATION;
   EFFICACY; SURGERY
AB Negative-pressure wound therapy (NPWT) is widely used in clinical practise to enhance wound healing; however, its biological effects on intact skin remain poorly understood. Given the expanding applications of NPWT, understanding its impact beyond open wounds is increasingly important. This study aimed to evaluate the biological responses of intact skin to negative-pressure, specifically focusing on epithelial-mesenchymal transition (EMT). The effects of negative-pressure loading were assessed using an in vitro model of non-diabetic human keratinocytes and an in vivo model of intact diabetic mouse skin. Human keratinocytes exposed to negative-pressure exhibited increased expression of thrombospondin-1 (THBS1), transforming growth factor-beta 1 (TGF-beta 1), plasminogen activator inhibitor-1 (PAI-1), and hypoxia-inducible factor 1-alpha (HIF-1 alpha), alongside decreased epithelial markers and increased mesenchymal markers. These EMT-related changes were mitigated by inhibiting the THBS1-TGF-beta 1 interaction. Similarly, in diabetic mice, intermittent negative-pressure loading applied to intact dorsal skin significantly increased THBS1 and TGF-beta 1 levels, resulting in epidermal and dermal thickening, and promoted hypoxic, prothrombotic and angiogenic responses, as evidenced by increased HIF-1 alpha, PAI-1, fibrinogen and vascular endothelial growth factor expression. These findings suggest that negative-pressure loading can induce EMT-like responses and tissue remodelling in intact skin primarily via mechanisms involving the THBS1-TGF-beta 1 signalling axis. This study expands the understanding of the biological influence of NPWT beyond traditional wound treatment applications, potentially informing future therapeutic considerations and safety guidelines.
C1 [Yamashiro, Toshifumi; Tsuchiya, Masato; Azuma, Ryuichi] Natl Def Med Coll, Dept Plast & Reconstruct Surg, Tokorozawa, Saitama, Japan.
   [Kushibiki, Toshihiro; Mayumi, Yoshine; Ishihara, Miya] Natl Def Med Coll, Dept Med Engn, Saitama, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan
RP Yamashiro, T (通讯作者)，Natl Def Med Coll, Dept Plast & Reconstruct Surg, Tokorozawa, Saitama, Japan.
EM tyamashiro6328@gmail.com
RI YAMASHIRO, Toshifumi/JJE-7945-2023; Azuma, Ryuichi/AAT-1125-2021
OI Kushibiki, Toshihiro/0000-0002-1705-1467
FU Japan Society for the Promotion of Science [20K12725]
FX This study was partially supported by the JSPS KAKENHI (20K12725).
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NR 55
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR 16
PY 2026
VL 23
IS 3
AR e70859
DI 10.1111/iwj.70859
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FJ7BW
UT WOS:001720373900001
PM 41840929
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhou, D
   Wang, W
AF Zhou, Dian
   Wang, Wen
TI Safety and Efficacy of Beraprost Sodium Combined with Negative Pressure
   Drip Irrigation in the Treatment of Diabetic Foot Ulcer: A Retrospective
   Cohort Study
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article; Early Access
DE Beraprost sodium; negative pressure drip irrigation; diabetic foot
   ulcer; safety; efficacy; retrospective cohort study
ID SKIN BLOOD-FLOW; WOUND THERAPY; MELLITUS
AB Background: Diabetic foot ulcer (DFU) is a major cause of infection-related hospitalization and amputation. Negative-pressure wound therapy with instillation and dwell time (NPWTi-d) is used for complex DFU, and beraprost sodium (BS), an oral prostacyclin analogue, may improve microcirculation; evidence for their combination is limited. Objective: To assess the safety and effectiveness of NPWTi-d plus BS versus NPWTi-d alone and BS with standard wound care in DFU. Methods: We retrospectively reviewed hospitalized DFU patients treated from February 2019 to April 2024. Of 667 screened patients, 590 met inclusion criteria and were grouped by therapy: NPWTi-d (n = 190), BS plus standard care (n = 200), and NPWTi-d plus BS (n = 200). Primary outcomes were 12-week healing rate, time to healing, and ulcer area reduction (ImageJ). Secondary outcomes included reinfection and DFU-related readmission at 12 weeks, 6 months, and 12 months, and quality of life (DFU-SF). Results: At 12 weeks, NPWTi-d plus BS achieved faster healing than NPWTi-d alone (mean difference 2.6 days; 95% CI 0.1-5.3; P = 0.042) and greater area reduction at weeks 8-12 (P < 0.05). DFU-SF improved in all groups, with consistently higher scores in the combination group (P < 0.001). Reinfection and readmission increased overtime in all groups; between-group differences were small and may reflect residual confounding. No treatment-related serious adverse events were documented. No major bleeding, symptomatic hypotension, or treatment discontinuation due to intolerance was documented during the 12-week treatment period; minor adverse events may be underreported due to the retrospective design. Conclusions: In this retrospective cohort, adding oral BS to NPWTi-d was associated with faster wound closure and better DFU-related quality of life. Prospective controlled studies are needed to confirm these findings.
C1 [Zhou, Dian] Jiangnan Univ, Affiliated Hosp, Burn & Trauma Treatment Ctr, Wuxi, Jiangsu, Peoples R China.
   [Wang, Wen] Jiangnan Univ, Wuxi 2 Peoples Hosp, Dept Endocrinol, Med Ctr, 68 Zhongshan Rd, Wuxi 214000, Jiangsu, Peoples R China.
C3 Jiangnan University; Jiangnan University
RP Wang, W (通讯作者)，Jiangnan Univ, Wuxi 2 Peoples Hosp, Dept Endocrinol, Med Ctr, 68 Zhongshan Rd, Wuxi 214000, Jiangsu, Peoples R China.
EM wangwen2405@126.com
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NR 28
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD 2026 MAR 24
PY 2026
DI 10.1177/15347346261435112
EA MAR 2026
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FL4MC
UT WOS:001721554500001
PM 41873580
OA Bronze
DA 2026-07-24
ER
PT J
AU Chen, X
   Fang, Y
   Jiang, LJ
   Chen, L
AF Chen, Xiang
   Fang, Yu
   Jiang, Linjun
   Chen, Lian
TI Comparative efficacy of vacuum sealing drainage with moist exposed burn
   ointment versus hydrogel dressing in pediatric open fracture wounds
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
LA English
DT Article
DE hydrogel dressing; moist exposed burn ointment; open fracture wounds;
   pediatric; vacuum sealing drainage
ID MANAGEMENT; THERAPY
AB Pediatric open fractures present major challenges in wound management because of high infection risk and delayed healing. This study compared the clinical efficacy of vacuum sealing drainage (VSD) combined with moist exposed burn ointment (MEBO) versus VSD combined with hydrogel dressings in pediatric open fracture wounds. A retrospective analysis was performed in 222 pediatric patients with refractory fracture wounds, including 119 treated with VSD + MEBO and 103 treated with VSD + hydrogel dressings. Outcomes assessed included wound healing time, overall treatment efficacy, total treatment cost, pain intensity evaluated using the Visual Analogue Scale (VAS), serum inflammatory markers [high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT), and interleukin-6 (IL-6)], and complication rates. Compared with the VSD + hydrogel group, the VSD + MEBO group demonstrated significantly faster wound healing and lower total treatment costs (both P < 0.001). VAS scores on days 3 and 5 after dressing application were also significantly lower in the VSD + MEBO group (P < 0.001). Moreover, serum levels of hs-CRP, PCT, and IL-6 on day 7 were significantly reduced in the VSD + MEBO group compared with the VSD + hydrogel group (P < 0.001). No significant differences were observed between the two groups in overall treatment efficacy or complication rates (P > 0.05), indicating comparable safety. In conclusion, VSD combined with MEBO accelerates wound healing, reduces inflammation and pain, and lowers treatment costs in pediatric open fracture wounds, demonstrating potential clinical advantages.
C1 [Chen, Xiang; Jiang, Linjun; Chen, Lian] Chongqing Med Univ, Childrens Hosp, Dept Orthopaed, 2 Zhongshan Rd, Chongqing 400014, Peoples R China.
   [Chen, Xiang; Jiang, Linjun; Chen, Lian] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Children & AdolescentsHealth & D, Chongqing, Peoples R China.
   [Chen, Xiang; Jiang, Linjun; Chen, Lian] Chongqing Med Univ, Childrens Hosp, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China.
   [Chen, Xiang; Jiang, Linjun; Chen, Lian] Chongqing Med Univ, Childrens Hosp, Chongqing Engn Res Ctr Stem Cell Therapy, Chongqing, Peoples R China.
   [Fang, Yu] Chongqing Med Univ, Affiliated Hosp 1, Dept Thorac & Cardiovasc Surg, Chongqing, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Chongqing
   Medical University; Chongqing Medical University; Chongqing Medical
   University
RP Chen, X (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Orthopaed, 2 Zhongshan Rd, Chongqing 400014, Peoples R China.
EM 345565061@qq.com
CR Bisztyga-Szklarz M, 2021, MATERIALS, V14, DOI 10.3390/ma14123171
   Bright LME, 2023, CURR OPIN COLLOID IN, V66, DOI 10.1016/j.cocis.2023.101704
   Cai LY, 2022, INJURY, V53, P777, DOI 10.1016/j.injury.2021.10.018
   Cao Z, 2020, Fa Yi Xue Za Zhi, V36, P104, DOI 10.12116/j.issn.1004-5619.2020.01.020
   Costa ML, 2018, JAMA-J AM MED ASSOC, V319, P2280, DOI 10.1001/jama.2018.6452
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Fraisse B, 2024, ORTHOP TRAUMATOL-SUR, V110, DOI 10.1016/j.otsr.2023.103771
   Gong YX, 2023, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.1042015
   Gu RT, 2023, NANOSCALE ADV, V5, P6017, DOI 10.1039/d3na00407d
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   Ji MR, 2025, INT J BIOL MACROMOL, V304, DOI 10.1016/j.ijbiomac.2025.140993
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   Wang ZH, 2020, J FOOT ANKLE SURG, V59, P409, DOI 10.1053/j.jfas.2019.08.016
   Xu YY, 2025, JOVE-J VIS EXP, DOI 10.3791/68649
   Yang JZ, 2022, COMPUT MATH METHOD M, V2022, DOI 10.1155/2022/8916076
   Yang ZF, 2021, ADV SCI, V8, DOI 10.1002/advs.202003627
   Yuan XG, 2016, ORTHOP TRAUMATOL-SUR, V102, P369, DOI 10.1016/j.otsr.2016.01.020
   Zhang LJ, 2019, FRONT BIOENG BIOTECH, V7, DOI 10.3389/fbioe.2019.00342
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   Zhao YY, 2025, APPL BIOCHEM BIOTECH, V197, P821, DOI 10.1007/s12010-024-05048-5
NR 30
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1060-152X
EI 1473-5865
J9 J PEDIATR ORTHOP B
JI J. Pediatr. Orthop.-Part B
PD MAY
PY 2026
VL 35
IS 3
BP 289
EP 294
DI 10.1097/BPB.0000000000001322
PG 6
WC Orthopedics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Pediatrics
GA FM2RC
UT WOS:001722111200004
PM 41533808
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Zhang, XC
   Shi, YL
   Yang, Y
AF Zhang, Xichun
   Shi, Yingli
   Yang, Yan
TI The influence of the IKAP nursing model on wound healing following
   vacuum sealing drainage in acute infective endocarditis: a retrospective
   study
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE acute infectiveEndocarditis; IKAP nursing model; retrospective study;
   vacuum sealing drainage; wound healing
ID CARE
AB Background Acute infective endocarditis (IE) presents clinical challenges due to its complex pathophysiology and potential for severe complications. Vacuum sealing drainage (VSD) is an essential treatment approach, and nursing care plays a pivotal role in patient outcomes. The Innovative Knowledge-Attitude-Practice (IKAP) nursing model is a patient-centered approach emphasizing health education, behavioral engagement, and self-management support. This study aimed to investigate the association between the IKAP nursing model and wound healing following VSD in patients with acute IE.Methods A retrospective analysis of 240 patients with acute IE undergoing VSD was conducted from January 2023 to December 2023. Patients were categorized into routine nursing (n = 117) and IKAP nursing (n = 123) groups based on admission period. Baseline characteristics, VSD details, laboratory results, medication usage, hospitalization details, wound size reduction, pain scores, and postoperative complications were compared. Multivariate logistic regression was performed to adjust for potential confounders.Results Baseline disease-related characteristics, VSD characteristics, and several laboratory parameters did not significantly differ between the two nursing groups. The IKAP nursing group demonstrated a lower white blood cell count (9.94 +/- 2.29 vs. 10.57 +/- 2.14 & times; 109/L, P = 0.029), greater wound size reduction at week 4 (3.52 +/- 0.82 vs. 3.77 +/- 0.95 cm2, P = 0.034), lower pain scores at week 4 (5.45 +/- 1.93 vs. 5.98 +/- 1.85, P = 0.031), and reduced incidence of wound infection (0.81% vs. 6.84%, adjusted OR = 0.11, 95% CI: 0.01-0.89, P = 0.034) and other adverse events (1.63% vs. 8.55%, adjusted OR = 0.18, 95% CI: 0.04-0.84, P = 0.031) following VSD. However, these differences were not sustained at week 8.Conclusion The findings suggest a potential association between the IKAP nursing model and improved wound healing, pain management, and reduced postoperative complications in patients undergoing VSD for acute IE, particularly during the early recovery phase. Given the retrospective nature and observed attenuation of effects at week 8, prospective studies are warranted to confirm these findings.
C1 [Zhang, Xichun; Yang, Yan] NanYang First Peoples Hosp, Dept Cardiovasc Med 1, Nanyang, Henan, Peoples R China.
   [Shi, Yingli] NanYang First Peoples Hosp, Dept Cardiac & Large Vasc Surg, Nanyang, Henan, Peoples R China.
RP Zhang, XC (通讯作者)，NanYang First Peoples Hosp, Dept Cardiovasc Med 1, Nanyang, Henan, Peoples R China.
EM zxc15503771143@163.com
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAR 11
PY 2026
VL 13
AR 1671655
DI 10.3389/fcvm.2026.1671655
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FM4UM
UT WOS:001722255700001
PM 41890872
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Martins, MAB
   Amador, WFO
   Oliveira, REND
   Duda, JR
   Formiga, FB
AF Martins, Marcelo Albuquerque Barbosa
   Amador, Wellgner Fernandes Oliveira
   da Nobrega Oliveira, Rachid Eduardo Noleto
   Duda, Joao Ricardo
   Formiga, Fernanda Bellotti
TI Negative pressure wound therapy in primary closure surgeries for
   pilonidal disease: a meta-analysis
SO UPDATES IN SURGERY
LA English
DT Review; Early Access
DE Negative pressure wound therapy; Pilonidal disease; Surgical wound
ID QUALITY-OF-LIFE; SINUS DISEASE; CARE; MANAGEMENT; MECHANISM
AB Primary closure with negative pressure wound therapy (NPWT) has been investigated in patients with sacrococcygeal pilonidal sinus to enhance healing and reduce recurrence. To address existing controversies, we conducted a systematic review and meta-analysis comparing primary closure with NPWT versus non-NPWT (control) for treatment of pilonidal disease. PubMed, Embase, and Cochrane Library databases were searched from inception to December 2024 to identify studies comparing NPWT versus control in primary closure surgeries in pilonidal sinus. Statistical analyses were performed using R Software with a random-effects model. Six studies with a total of 479 patients were included, of whom 164 (34.2%) underwent NPWT. NPWT had an association with lower pain score 24 h postoperative (MD - 0.65 points; 95% CI - 0.81 to - 0.50), shorter return time to activities (MD - 2.57 days; 95% CI - 3.74 to - 1.4). However, there was no difference between groups in the time of wound closure (MD - 18.94; 95% CI - 41.68 to 3.80), rate of wound dehiscence (RR 1.03; 95% CI 0.50 to 2.14), hospital length of stay (MD - 3.05; 95% CI - 15.77 to 9.67), infection rates (RR 0.38; 95% CI 0.05 to 2.84), recurrence rates (RR 0.54; 95% CI 0.07 to 4.48), and pain 6 h post-operative, which showed a borderline trend favoring NPWT but did not reach statistical significance (MD - 1.19; 95% CI - 2.38 to 0.01). NPWT appears to shorten time to resume normal activities and pain 24 h postoperatively. Despite these promising results, more randomized clinical trials are needed for greater analysis.
C1 [Martins, Marcelo Albuquerque Barbosa] Univ Fed Ouro Preto, Ouro Preto, MG, Brazil.
   [Amador, Wellgner Fernandes Oliveira] Univ Fed Campina Grande, Cajazeiras, PB, Brazil.
   [da Nobrega Oliveira, Rachid Eduardo Noleto] Barretos Canc Hosp, Barretos, SP, Brazil.
   [Duda, Joao Ricardo] Pontificia Univ Catolica Parana, Curitiba, PR, Brazil.
   [Formiga, Fernanda Bellotti] Santa Casa Sao Paulo, Colorectal Surg Unit, Sao Paulo, SP, Brazil.
   [Formiga, Fernanda Bellotti] Hosp Heliopolis, Colorectal Surg Unit, Sao Paulo, SP, Brazil.
C3 Universidade Federal de Ouro Preto; Universidade Federal de Campina
   Grande; Hospital de Cancer de Barretos; Pontificia Universidade Catolica
   do Parana
RP Amador, WFO (通讯作者)，Univ Fed Campina Grande, Cajazeiras, PB, Brazil.
EM marceloalbuquerque23.1.2008@gmail.com; wellgnerfernandes@gmail.com;
   toraxbarretos@gmail.com; joaorduda@gmail.com;
   drafernandaformiga@gmail.com
RI Duda, Joao/LLM-4814-2024; Noleto da Nobrega Oliveira, Rachid
   Eduardo/NOE-9733-2025; FORMIGA, Fernanda/MCJ-6517-2025
OI Fernandes Oliveira Amador, Wellgner/0009-0002-3186-2589; 
CR Amorim M, 2023, SURGERY, V174, P480, DOI 10.1016/j.surg.2023.05.035
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NR 34
TC 3
Z9 3
U1 1
U2 1
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD 2026 MAR 25
PY 2026
DI 10.1007/s13304-026-02536-7
EA MAR 2026
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FN5RF
UT WOS:001722995000001
PM 41880146
DA 2026-07-24
ER
PT J
AU Ahmad, J
   Hindawi, MD
   Hamdy, AM
   AL-Ihribat, AR
   Salloum, OH
   Marrawani, M
   Jibril, NS
   Elewidi, M
   Elbelkasi, H
   Kalmoush, A
   Kirkpatrick, AW
   Tan, ECTH
AF Ahmad, Jamal
   Hindawi, Mahmoud Diaa
   Hamdy, Ahmed Mohamed
   Al-Ihribat, Alaa R.
   Salloum, Omar Hammam
   Marrawani, Mohammad
   Jibril, Nada S.
   Elewidi, Mariam
   Elbelkasi, Hamdi
   Kalmoush, Abd-Elfattah
   Kirkpatrick, Andrew W.
   Tan, Edward C. T. H.
TI Closed incision negative pressure wound therapy after emergency
   laparotomy: a systematic review and Meta-analysis of randomized
   controlled trials
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Emergency laparotomy; Acute care surgery; Negative pressure wound
   therapy; Surgical site infection; Incisional NPWT; Wound complications
ID PREVENTION
AB PurposeEmergency laparotomy is associated with high rates of postoperative wound complications, contributing substantially to patient morbidity and healthcare burden. Closed incision negative pressure wound therapy (ciNPWT) has been proposed as a prophylactic strategy to reduce wound-related complications; however, its effectiveness in the emergency laparotomy setting remains uncertain. We evaluated whether ciNPWT reduces wound complications after emergency laparotomy compared with standard dressings.MethodsThis study is a systematic review and meta-analysis of randomized controlled trials (RCTs). Six databases and trial registries were systematically searched for RCTs from inception to October 10, 2025, with the search subsequently updated using automated database alerts (RSS) up to the time of manuscript submission.ResultsSix randomized controlled trials (1208 patients) were included. Compared with standard dressings, ciNPWT reduced overall wound morbidity (RR 0.49, 95% CI 0.38-0.62; I2 = 0%) and overall SSI (RR 0.40, 95% CI 0.26-0.61; I2 = 0%). ciNPWT also reduced superficial SSI (RR 0.46, 95% CI 0.24-0.85) and wound dehiscence (RR 0.40, 95% CI 0.20-0.80). No significant differences were observed for seroma (RR 0.59, 95% CI 0.34-1.01), length of hospital stay (MD - 0.43 days, 95% CI- 1.14 to 0.29), mortality (RR 1.18, 95% CI 0.64-2.15), or 30-day complications (RR 0.98, 95% CI 0.85-1.15).ConclusionIn adult patients undergoing emergency laparotomy with primary abdominal closure, ciNPWT significantly reduces key incision-related complications, particularly superficial SSI and wound dehiscence. Its clinical benefit appears confined to incision-level outcomes, with no effect on systemic or multifactorial postoperative endpoints. These findings support the selective use of ciNPWT in high-risk emergency laparotomy patients and highlight the need for standardized application protocols and longer-term outcome assessment.
C1 [Ahmad, Jamal; Al-Ihribat, Alaa R.; Salloum, Omar Hammam; Marrawani, Mohammad] Palestine Polytech Univ, Fac Med, Hebron, Palestine.
   [Hindawi, Mahmoud Diaa] Al Azhar Univ, Fac Med, Cairo, Egypt.
   [Hindawi, Mahmoud Diaa] Negida Acad, Arlington, MA USA.
   [Hamdy, Ahmed Mohamed] Zagazig Univ, Fac Med, Sharkia, Egypt.
   [Salloum, Omar Hammam] Palestinian Clin Res Ctr, Bethlehem, Palestine.
   [Jibril, Nada S.] Menoufia Univ, Fac Med, Menoufia, Egypt.
   [Elewidi, Mariam] Tanta Univ, Fac Med, Tanta, Egypt.
   [Elbelkasi, Hamdi] Mataryia Teaching Hosp GOTHI, Cairo, Egypt.
   [Kalmoush, Abd-Elfattah] Al Azhar Univ, Gen Surg Dept, Cairo, Egypt.
   [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Crit Care Med, Calgary, AB, Canada.
   [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Surg, Calgary, AB, Canada.
   [Tan, Edward C. T. H.] Radboud Univ Nijmegen, Dept Surg, Med Ctr, Nijmegen, Netherlands.
C3 Palestine Polytechnic University; Egyptian Knowledge Bank (EKB); Al
   Azhar University; Egyptian Knowledge Bank (EKB); Zagazig University;
   Egyptian Knowledge Bank (EKB); Menofia University; Egyptian Knowledge
   Bank (EKB); Tanta University; Egyptian Knowledge Bank (EKB); Al Azhar
   University; University of Calgary; University Calgary Hospital;
   University of Calgary; University Calgary Hospital; Radboud University
   Nijmegen
RP Tan, ECTH (通讯作者)，Radboud Univ Nijmegen, Dept Surg, Med Ctr, Nijmegen, Netherlands.
EM dr.md.hunt@gmail.com; Edward.tan@radboudumc.nl
RI Salloum, Omar/AFW-7490-2022; Al-Ihribat, Alaa/LBI-3214-2024; Tan,
   Edward/L-4681-2015; Kalmoush, Abd-Elfattah/ABP-3296-2022; Hindawi,
   Mahmoud Diaa/QAX-6061-2026
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NR 31
TC 1
Z9 1
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD FEB 17
PY 2026
VL 21
IS 1
AR 16
DI 10.1186/s13017-026-00679-x
PG 14
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA FN6MC
UT WOS:001723049300001
PM 41703609
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Fuchs, N
   Pavljak, L
   Hauptman, D
   Mance, M
AF Fuchs, Nino
   Pavljak, Lucija
   Hauptman, Dinko
   Mance, Marko
TI Two-Stage Surgical Management of Anogenital Hidradenitis Suppurativa in
   Patients on Biologic Therapy: A Retrospective Case Series
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE anogenital region; biologic therapy; hidradenitis suppurativa; two-stage
   surgery
ID PRESSURE WOUND THERAPY
AB Hidradenitis suppurativa is a chronic inflammatory skin disorder causing painful nodules, abscesses and scarring, with the anogenital region presenting particular functional and reconstructive challenges. Although biologic therapy is commonly used in moderate to severe disease, its limitations highlight the role of surgery in advanced cases. This single-centre retrospective case series included five male patients with Hurley stage III perineal, anorectal, genital or gluteal disease treated surgically between 2021 and 2023 following failure of biologic therapy. Management consisted of two-stage radical excision, negative-pressure wound therapy and reconstruction with meshed split-thickness skin grafts. All patients achieved more than 90% graft take and complete wound healing. No recurrence occurred during a median follow-up of 19.2 months. One patient developed a keloid scar at the donor site, and one experienced delayed healing. Functional and aesthetic results were satisfactory in all cases. Two-stage surgical excision with split-thickness skin graft reconstruction was associated with sustained wound healing and favourable functional outcomes in selected patients with severe anogenital hidradenitis suppurativa refractory to biologic therapy.
C1 [Fuchs, Nino; Pavljak, Lucija; Mance, Marko] Univ Hosp Ctr Zagreb, Dept Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.
   [Pavljak, Lucija] Gen Hosp, Dept Vasc & Plast Surg & Urol, Koprivnica, Croatia.
   [Hauptman, Dinko] Univ Ctr Zagreb, Dept Urol, Zagreb, Croatia.
C3 University of Zagreb; University of Zagreb Hospital; University of
   Zagreb
RP Pavljak, L (通讯作者)，Univ Hosp Ctr Zagreb, Dept Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.; Pavljak, L (通讯作者)，Gen Hosp, Dept Vasc & Plast Surg & Urol, Koprivnica, Croatia.
EM lucija.pavljak@student.mef.hr
CR Abbvie, HUMIRA ADALIMUMAB
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NR 36
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR 26
PY 2026
VL 23
IS 4
AR e70874
DI 10.1111/iwj.70874
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO9DZ
UT WOS:001723912700001
PM 41884971
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhang, P
   Luo, J
   Yuan, LL
   Huang, YS
   Xiang, F
AF Zhang, Peng
   Luo, Jia
   Yuan, Li-li
   Huang, Yue-sheng
   Xiang, Fei
TI Negative Pressure Wound Therapy Improves the Survival Rate of Meek Skin
   Grafting in Burn Patients: A Prospective Randomized Controlled Study in
   a Single Center
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
DE burn; negative pressure wound therapy; Meek skin grafting; skin survival
   rate
ID VACUUM-ASSISTED CLOSURE; BACTERIAL LOAD; EXPERIENCE
AB This study aimed to determine whether negative pressure wound therapy (NPWT) improved the survival rate of Meek skin grafting compared to that of traditional dressing in patients with burn injuries. Thirteen patients with burn injuries of similar depths on both limbs were admitted, the limbs were divided into the NPWT + Meek group and the Meek group. The polyamide gauze adherence rate, the wound secretion culture result and the skin survival rate between the 2 groups were compared. The polyamide gauze adherence rate and the skin survival rate in the NPWT + Meek group were higher than those in the Meek group. Therefore, replacing traditional dressing with NPWT for bandaging after Meek skin grafting can improve the skin survival rate.
C1 [Zhang, Peng] Outpatient Dept, 75610 Unit, Shenzhen 518000, Peoples R China.
   [Luo, Jia; Yuan, Li-li; Xiang, Fei] Army Med Univ, Southwest Hosp, Inst Burn Res, State Key Lab Trauma & Chem Poisoning, Chongqing 400038, Peoples R China.
   [Huang, Yue-sheng] Southern Univ Sci Technol, Southern Univ Sci & Technol Hosp, Technol Hosp,Sch Med,Dept Wound Repair, Inst Wound Repair & Regenerat Med, Shenzhen 518055, Peoples R China.
C3 Army Medical University; Southern University of Science & Technology
RP Xiang, F (通讯作者)，Army Med Univ, Southwest Hosp, Inst Burn Res, State Key Lab Trauma & Chem Poisoning, Chongqing 400038, Peoples R China.; Huang, YS (通讯作者)，Southern Univ Sci Technol, Southern Univ Sci & Technol Hosp, Technol Hosp,Sch Med,Dept Wound Repair, Inst Wound Repair & Regenerat Med, Shenzhen 518055, Peoples R China.
EM yshuang1958@163.com; xftmmu99@tmmu.edu.cn
FU Talent training program of Army Medical University [xz-2019-505-046];
   Natural Science Foundation of Chongqing [CSTC2021JCYJ-MSXMX0577]
FX The study was supported by the Talent training program of Army Medical
   University (xz-2019-505-046). Natural Science Foundation of Chongqing
   (No. CSTC2021JCYJ-MSXMX0577).
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NR 22
TC 0
Z9 0
U1 1
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2026
VL 47
IS 4
BP 1089
EP 1095
DI 10.1093/jbcr/irag040
EA MAR 2026
PG 7
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA KP6OA
UT WOS:001725362100001
PM 41800546
DA 2026-07-24
ER
PT J
AU Pessarelli, T
   Bergna, IMB
   Boemo, C
   De Monti, A
   La Milia, M
   Hervoso, CM
   Pagliarulo, M
   Piagnani, A
   Zago, M
   Amato, A
AF Pessarelli, Tommaso
   Bergna, Irene Maria Bambina
   Boemo, Cinzia
   De Monti, Alberta
   La Milia, Marta
   Marfinati Hervoso, Cristina
   Pagliarulo, Michela
   Piagnani, Alessandra
   Zago, Mauro
   Amato, Arnaldo
TI Interventional Endoscopy for the Management of Post-Surgical Leaks and
   Fistulas: A Scoping Review
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE post-surgical leak; post-surgical fistula; interventional endoscopy;
   gastrointestinal endoscopy; over-the-scope clip; endoscopic vacuum
   therapy; VACstent; endoscopic suturing; endoscopic internal drainage
ID VACUUM-ASSISTED CLOSURE; GASTROINTESTINAL DEFECTS; MULTICENTER
   EXPERIENCE; SLEEVE GASTRECTOMY; INTERNAL DRAINAGE; CLINICAL-OUTCOMES;
   THERAPY; STENT; ESOPHAGECTOMY; COMPLICATIONS
AB Background/Objectives: Leaks and fistulas are serious surgical complications associated with substantial morbidity and mortality. Traditional management has relied on surgical reintervention or percutaneous drainage, both of which carry significant risks. In recent decades, interventional endoscopy has emerged as a minimally invasive alternative, offering a growing range of therapeutic options. This scoping review aimed to systematically map the available evidence on endoscopic management of post-surgical leaks and fistulas, with a focus on techniques used, indications, outcomes, and gaps in the literature. Methods: This scoping review was conducted according to PRISMA-ScR guidelines. PubMed/MEDLINE, Embase, and Scopus were searched from inception to 5 December 2025. Eligible studies included original studies, systematic reviews, and narrative reviews reporting therapeutic endoscopic interventions for post-surgical leaks or fistulas in any patient population. Case reports and case series with fewer than 20 patients were excluded. Data were charted on study design, surgical context, endoscopic techniques, and reported outcomes. Results: A total of 69 studies were included, comprising 46 original studies involving 2550 patients, along with 11 systematic reviews and 12 narrative reviews. Endoscopic techniques identified included through-the-scope and over-the-scope clipping, stenting, endoscopic vacuum therapy, internal drainage, tissue sealants, endoscopic suturing, and hybrid devices such as VAC-Stent (R). Reported technical and clinical success rates varied widely across techniques and clinical settings, influenced by defect characteristics, timing of intervention, anatomical location, and operator experience. Endoscopic vacuum therapy was supported by the most consistent evidence, particularly for esophageal and colorectal leaks. Conclusions: Interventional endoscopy represents an increasingly central component in the management of post-surgical leaks and fistulas, enabling individualized, less invasive treatment strategies. However, the current evidence base remains heterogeneous and largely retrospective, underscoring the need for well-designed, multicenter prospective studies.
C1 [Pessarelli, Tommaso; Bergna, Irene Maria Bambina; Boemo, Cinzia; De Monti, Alberta; La Milia, Marta; Marfinati Hervoso, Cristina; Pagliarulo, Michela; Piagnani, Alessandra; Amato, Arnaldo] Osped A Manzoni Hosp, Digest Endoscopy & Gastroenterol Dept, I-23900 Lecce, Italy.
   [Zago, Mauro] Osped A Manzoni Hosp, Dept Gen Surg, I-23900 Lecce, Italy.
RP Amato, A (通讯作者)，Osped A Manzoni Hosp, Digest Endoscopy & Gastroenterol Dept, I-23900 Lecce, Italy.
EM t.pessarelli@asst-lecco.it; i.bergna@asst-lecco.it;
   c.boemo@asst-lecco.it; a.demonti@asst-lecco.it; m.lamilia@asst-lecco.it;
   c.marfinatihervo@asst-lecco.it; m.pagliarulo@asst-lecco.it;
   a.piagnani@asst-lecco.it; m.zago@asst-lecco.it; a.amato@asst-lecco.it
RI Amato, Arnaldo/ABC-5688-2020
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   Zhong LQ, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.657955
NR 56
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR 17
PY 2026
VL 15
IS 6
AR 2291
DI 10.3390/jcm15062291
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FR5MI
UT WOS:001725696300001
PM 41899214
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lee, JH
   Kim, TG
AF Lee, Joon Hyuk
   Kim, Tae Gon
TI Quadrilateral Pinwheel Flap Reconstruction for a Complex Colocutaneous
   Fistula-Associated Flank Wound in a Paraplegic Patient: A Case Report
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE paraplegia; colonic fistula; surgical flaps; wound healing;
   negative-pressure wound therapy
ID ULCERS
AB Background/Objectives: Chronic wounds are a major source of morbidity in patients with paraplegia, often resulting in repeated treatment, prolonged hospitalization, and reduced quality of life. Reconstruction becomes particularly challenging when a wound arises in a scarred trunk region and is further complicated by deep infection, osteomyelitis, or enteric fistula. We describe the staged management of a complex left flank wound in a paraplegic patient, initially reconstructed with a quadrilateral pinwheel flap and later requiring multidisciplinary salvage for recurrence associated with rib osteomyelitis and a colocutaneous fistula. Methods: A paraplegic man in his 50s presented with a chronic left flank wound after repeated full-thickness skin graft failure and persistent Pseudomonas aeruginosa infection. After wide debridement, the approximately 7 & times; 7 cm defect was reconstructed with a quadrilateral pinwheel flap composed of four Limberg-style rhomboid fasciocutaneous flaps positioned at the 12, 3, 6, and 9 o'clock orientations, elevated at the level of the deep fascia, and transposed into the central defect, with adjunctive negative-pressure wound therapy (NPWT). Approximately 1 year later, recurrence with rib osteomyelitis required rib resection. During NPWT, feculent drainage led to the diagnosis of a colocutaneous fistula. Subsequent multidisciplinary treatment included fistula tract resection, colonic repair with omental patching, transposition of vascularized omentum into the chest wall cavity to obliterate dead space, continued NPWT, and delayed primary closure. Results: Initial local flap reconstruction achieved wound coverage, and immediate postoperative clinical assessment, including pinprick and refill testing, confirmed satisfactory flap perfusion; however, delayed recurrence developed in association with rib osteomyelitis. After definitive fistula surgery, dead-space management with vascularized omentum, wound conditioning with staged NPWT, and delayed primary closure, the wound healed completely. At 6 months after delayed closure, no recurrence of fistula, osteomyelitis, wound dehiscence, or soft-tissue breakdown was observed, and the patient's daily comfort and functional independence were improved compared with the preoperative condition. Conclusions: A quadrilateral pinwheel flap may provide an effective tension-dispersing local fasciocutaneous option for selected scarred trunk defects in high-risk patients. However, when chronic wounds are compounded by deep infection and enteric fistula, durable healing depends not on flap design alone but on staged multidisciplinary management incorporating definitive source control, vascularized tissue transfer for dead-space elimination, NPWT, and appropriately timed closure.
C1 [Lee, Joon Hyuk; Kim, Tae Gon] Yeungnam Univ, Coll Med, Dept Plast & Reconstruct Surg, 170 Hyeonchung Ro, Daegu 42415, South Korea.
C3 Yeungnam University
RP Kim, TG (通讯作者)，Yeungnam Univ, Coll Med, Dept Plast & Reconstruct Surg, 170 Hyeonchung Ro, Daegu 42415, South Korea.
EM mericle@naver.com; kimtg0919@gmail.com
CR Ghimire P, 2022, J NEPAL MED ASSOC, V60, P93, DOI 10.31729/jnma.5780
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NR 11
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR 20
PY 2026
VL 15
IS 6
AR 2394
DI 10.3390/jcm15062394
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FR6PY
UT WOS:001725773300001
PM 41899317
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ciuntu, BM
   Ludusanu, A
   Tanevscki, A
   Costârnache, RS
   Corlade-Andrei, M
   Soroceanu, PR
   Vintila, D
   Abdulan, IM
   Zabara, ML
   Balan, G
AF Ciuntu, Bogdan-Mihnea
   Ludusanu, Andreea
   Tanevscki, Adelina
   Costarnache, Rares Stefan
   Corlade-Andrei, Mihaela
   Soroceanu, Petru Radu
   Vintila, Dan
   Abdulan, Irina Mihaela
   Zabara, Mihai-Lucian
   Balan, Gheorghe
TI EndoVAC Therapy for Post-TEVAR Secondary Esophageal Fistula: A Rare Case
   of Delayed Secondary Esophageal Fistula After TEVAR Managed with
   Endoluminal Vacuum Therapy
SO LIFE-BASEL
LA English
DT Article
DE aorto-esophageal fistula; secondary esophageal fistula; thoracic
   endovascular aortic repair (TEVAR); endograft erosion; multidisciplinary
   approach
ID ENDOVASCULAR AORTIC REPAIR; AORTOESOPHAGEAL FISTULA; SOCIETY
AB Background: Aorto-esophageal fistula is a rare but life-threatening condition most often linked to thoracic aortic aneurysms and significant upper gastrointestinal bleeding. Thoracic endovascular aortic repair (TEVAR) is a crucial, life-saving procedure, but delayed complications, such as secondary esophageal fistulas caused by endograft erosion, can develop. Prompt recognition and multidisciplinary management are vital for survival. Case Presentation: We describe a 57-year-old patient with cardiovascular comorbidities and a saccular thoracic aortic aneurysm, who initially presented with massive hematemesis, melena, and hemodynamic instability. Imaging showed an aorto-esophageal fistula. Emergency treatment included placing a fully covered esophageal stent followed by TEVAR. Three weeks later, he experienced fever, chest pain, and worsening dysphagia. Laboratory tests indicated elevated inflammatory markers and hypoalbuminemia. Computed tomography revealed a new retrocardial esophageal fistula at T9, caused by mechanical erosion from the thoracic endograft. Endoluminal vacuum-assisted closure (EndoVAC) therapy was performed, leading to clinical improvement and the return of esophageal function. Conclusions: This case highlights a rare instance of a delayed secondary esophageal fistula after TEVAR beneath a preexisting stent, likely due to chronic contact between the endograft and esophagus. Despite advancements in endoscopic therapy, secondary fistulas after TEVAR are associated with high morbidity. Early diagnosis, aggressive infection management, structured nutritional support, and a multidisciplinary approach are essential. Extraluminal or intraluminal vacuum-assisted closure offers a promising minimally invasive option for managing complex esophageal defects.
C1 [Ciuntu, Bogdan-Mihnea; Ludusanu, Andreea; Tanevscki, Adelina; Soroceanu, Petru Radu; Vintila, Dan; Zabara, Mihai-Lucian] Univ Med & Pharm Grigore T Popa, Fac Med, Dept Gen Surg, Iasi 700115, Romania.
   [Ciuntu, Bogdan-Mihnea; Ludusanu, Andreea; Tanevscki, Adelina; Soroceanu, Petru Radu; Vintila, Dan; Zabara, Mihai-Lucian] St Spiridon Cty Emergency Clin Hosp, Gen Surg Clin, 1 Independence Blvd, Iasi 700111, Romania.
   [Costarnache, Rares Stefan] Univ Med & Pharm Grigore T Popa, Fac Med, Iasi 700115, Romania.
   [Corlade-Andrei, Mihaela] Univ Med & Pharm Grigore T Popa, Dept Emergency Med, Surg 2, Iasi 700115, Romania.
   [Abdulan, Irina Mihaela] Univ Med & Pharm Grigore T Popa, Dept Med Specialties 1, Iasi 700115, Romania.
   [Balan, Gheorghe] Univ Med & Pharm Grigore T Popa, Dept Gastroenterol, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy
RP Costârnache, RS (通讯作者)，Univ Med & Pharm Grigore T Popa, Fac Med, Iasi 700115, Romania.; Abdulan, IM (通讯作者)，Univ Med & Pharm Grigore T Popa, Dept Med Specialties 1, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; andreealudusanu1106@yahoo.com;
   papancea.adelina@umfiasi.ro; rcostarnache@yahoo.com;
   mihaela.corlade2@umfiasi.ro; petru.soroceanu@umfiasi.ro;
   dan.vintila@umfiasi.ro; irina.abdulan@yahoo.com;
   mihai-lucian.zabara@umfiasi.ro; gheorghe-g-balan@umfiasi.ro
RI Ciuntu, Bogdan/MTF-9477-2025; Corlade-Andrei, Mihaela/HGB-3725-2022;
   Abdulan, Irina/AAA-3089-2020
CR Abdulsada Mustafa, 2020, VideoGIE, V5, P8, DOI [10.1016/j.vgie.2019.10.004, 10.1016/j.vgie.2019.10.004]
   Canaud L., 2013, EUR J VASC ENDOVASC, V45, P282, DOI [10.1016/j.ejvs.2012.12.006, DOI 10.1016/J.EJVS.2012.12.006]
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NR 24
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD MAR 11
PY 2026
VL 16
IS 3
AR 460
DI 10.3390/life16030460
PG 9
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA FS6RP
UT WOS:001726453600001
PM 41900978
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Xu, ZY
   Cui, XY
   Chu, HB
   Wan, H
   Xie, YB
   Wang, Y
   Ni, QB
   Ding, XL
   Song, GH
AF Xu, Ziyu
   Cui, Xinyu
   Chu, Houbin
   Wan, Hao
   Xie, Yunbo
   Wang, Ying
   Ni, Qingbin
   Ding, Xiaolin
   Song, Guohua
TI Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot
   Ulcer via Promoting Mitophagy
SO JOURNAL OF DIABETES
LA English
DT Article
DE diabetic foot ulcer; hydrogen-enriched hyaluronic acid dressing;
   mitophagy; SIRT3
ID PROTECTS; PINK1
AB Objective Diabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study developed a hydrogen-enriched hyaluronic acid (HA) dressing and aimed to explore its therapeutic effects and mechanisms in DFU treatment.Methods A combination of vacuum-assisted closure (VSD) and hydrogen-rich saline was used to treat DFU patients and assess the clinical outcomes of wound repair. A rat model of DFU was established, and treatment with hydrogen-enriched HA dressing. Subsequently, the protective effects of the dressing were evaluated, including histological studies, the expression of inflammatory factors and angiogenesis markers. Western blot was used to analyze the expression levels of mitophagy-related proteins. In vitro, the role of HA and hydrogen on cell mitochondrial damage, apoptosis, migration, and markers associated with mitophagy pathways in human foreskin fibroblast-1 (HFF-1) was assessed.Results VSD combined with hydrogen-rich saline significantly enhanced wound healing in patients, while reducing inflammation and oxidative damage. In vivo studies showed that the dressing promoted wound healing, increased collagen deposition, reduced inflammatory cytokines, and enhanced neovascularization. In vitro studies, high glucose induced cell morphological damage and oxidative stress, disrupted mitochondrial membrane potential, leading to apoptosis and attenuating cell migration. However, both HA and hydrogen significantly induced SIRT3 expression and activated the downstream FOXO3A/PINK1-PARKIN signaling pathway, promoting mitochondrial autophagy and reducing cell apoptosis. Furthermore, the SIRT3/SOD2 pathway was also activated, decreasing reactive oxygen species (ROS) production and enhancing migration.Conclusion This study confirmed that the hydrogen-enriched HA dressing has the potential to enhance diabetic wound repair.
C1 [Xu, Ziyu; Cui, Xinyu; Chu, Houbin; Wan, Hao; Xie, Yunbo; Wang, Ying; Ding, Xiaolin; Song, Guohua] Shandong First Med Univ, Affiliated Hosp 2, Tai An, Peoples R China.
   [Xu, Ziyu; Cui, Xinyu; Chu, Houbin; Xie, Yunbo; Wang, Ying; Song, Guohua] Shandong First Med Univ & Shandong Acad Med Sci, Sch Basic Med Sci, Jinan, Peoples R China.
   [Xu, Ziyu] Zaozhuang Municipal Hosp, Zaozhuang, Peoples R China.
   [Ni, Qingbin] Taian Cent Hosp, Tai An, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical Sciences
RP Ding, XL; Song, GH (通讯作者)，Shandong First Med Univ, Affiliated Hosp 2, Tai An, Peoples R China.; Song, GH (通讯作者)，Shandong First Med Univ & Shandong Acad Med Sci, Sch Basic Med Sci, Jinan, Peoples R China.
EM ankle163@163.com; girl_sapphire@hotmail.com
FU National Natural Science Foundation of China [82370446, 81873517]
FX Funding for this research was provided by the National Natural Science
   Foundation of China (No. 82370446 and 81873517).
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NR 50
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD MAR 29
PY 2026
VL 18
IS 4
AR e70209
DI 10.1111/1753-0407.70209
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FU4NX
UT WOS:001727663300001
PM 41906653
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chen, HQ
   Zhao, XF
   Gao, S
   Qin, CJ
   Zhao, GQ
AF Chen, Haiqiong
   Zhao, Xufei
   Gao, Shi
   Qin, Chaojin
   Zhao, Guoqiang
TI Diagnosis and treatment of chronic infection after internal fixation for
   long bone fractures in children: a report of 6 cases
SO SEMINARS IN PEDIATRIC SURGERY
LA English
DT Article
DE Children long bone fracture; Chronic infection; Internal fixation
   retention; Treatment features
ID CHRONIC OSTEOMYELITIS
AB Objective: : To analyze the diagnosis and treatment of infection following internal fixation for long bone fractures in children. Methods: From January 2022 to 2024, 6 children with chronic infection following internal fixation for long bone fractures were admitted to the Department of Trauma. All the cases showed chronic infection with nonunion of the fracture, including 4 males and 2 females, 4 cases of falling from height, 1 case of traffic accident and 1 case of falling injury. The patients were treated with repeated debridement, antibiotic calcium sulfate filling, bone grafting, and intravenous antibioticsstable. The patients were followed up for at least 3 months after discharge, the symptoms, signs, and imaging changes were observed, and the Paley Fracture Healing Score.1 was recorded at the last follow-up. Results: All patients on admission showed different degrees of fracture nonunion or thinning of the fracture on X-rays, but the internal fixation was stable and the infection site was covered by soft tissue. All patients retained their implants and were treated 2-5 vacuum sealing drainage (VSD), antibiotic calcium sulfate combined with bone graft local anti-infection treatment. Secondly, Linezolid was the main antibiotic used in the perioperative and postoperative period, and Rifampicin (RFP) was added to 3 cases. Bacterial culture showed that 3 cases were Gram-positive bacteria (G+), 1 case was Serratia marcescens, and Sulperazon were added, Pseudomonas aeruginosa and Klebsiella variicola (Gram-negative bacteria, G-) were isolated from the 2 cases, and Meropenem and Imipenem (IPM) were added to increase the antimicrobial spectrum, respectively. All patients were followed up for 4-14 months, with an average of 7.8 months and achieved clinical healing without recurrence of infection. According to the Paley Fracture Healing Score1, the results were excellent in 5 patients and good in 1 patient. Conclusion: In 6 children with chronic infection after internal fixation of fracture, imaging showed nonunion of fracture. In order to avoid secondary internal fixation of fracture or later orthopedic surgery, careful retention of internal fixation, thorough debridement, local antibiotic filling and release of anti-infection, combined with systemic antibiotic treatment for a sufficient period, and constant monitoring of inflammatory indicators were performed. Infection control and fracture healing can be achieved clinically.
C1 [Chen, Haiqiong; Zhao, Xufei; Gao, Shi; Qin, Chaojin; Zhao, Guoqiang] Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Childrens Hlth & Dis, Dept Traumatol,Sch Med, hangzhou, Peoples R China.
C3 Zhejiang University
RP Zhao, GQ (通讯作者)，Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Childrens Hlth & Dis, Dept Traumatol,Sch Med, hangzhou, Peoples R China.
EM friendlongzju@163.com
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NR 34
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1055-8586
EI 1532-9453
J9 SEMIN PEDIATR SURG
JI Semin. Pediatr. Surg.
PD FEB
PY 2026
VL 40
AR 151589
DI 10.1016/j.sempedsurg.2026.151589
EA FEB 2026
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA FV1JC
UT WOS:001728126000001
PM 41692667
OA hybrid
DA 2026-07-24
ER
PT J
AU Sivash, I
   Koval, B
AF Sivash, Iurii
   Koval, Boris
TI NPWT in combat-related extremity vascular injuries: a case series and
   safety algorithm
SO BMJ MILITARY HEALTH
LA English
DT Article; Early Access
DE TRAUMA MANAGEMENT; Combat Disorders; WOUND MANAGEMENT; SURGERY; Vascular
   surgery; Trauma management
ID PRESSURE WOUND THERAPY; MANAGEMENT; MILITARY; CLOSURE; IRAQ
AB Introduction Combat extremity vascular injuries are frequently associated with extensive soft-tissue loss and contamination, increasing the risk of infection, graft thrombosis and erosion-related bleeding (ERB). Negative pressure wound therapy (NPWT) is widely used to manage complex combat wounds, but evidence regarding its use after vascular reconstruction remains limited.Methods We retrospectively analysed 69 patients with combat-related vascular injuries who underwent NPWT at a Role IV (Echelon of Care in the Military Medical System) facility in Ukraine during 2022. NPWT applications were categorised into two predefined groups: an interface group-NPWT applied adjacent to exposed vascular reconstructions using a protective multilayer system (n=28); and a covered group-NPWT applied over established soft-tissue or muscle flap coverage (n=41). Outcomes included ERB, graft thrombosis, infectious complications and limb loss. NPWT was applied as part of staged wound management following debridement and revascularisation.Results ERB occurred exclusively in the interface group (9/28, 32.1%) and was not observed in the covered group (0/41). ERB events were observed only prior to stable soft-tissue or flap coverage. Graft thrombosis (14.3% vs 4.9%), wound infection (10.7% vs 2.4%) and secondary amputations (7.1% vs 0%) were more frequent in the interface group. Overall limb salvage was 97.1%. Two ERB risk windows were observed: postoperative days 7-10 (mechanical) and 18-30 (infection-related).Conclusions NPWT may be incorporated into staged wound management following combat-related extremity vascular reconstruction; however, outcomes differed according to the soft-tissue coverage strategy employed. Application of NPWT near exposed vascular repairs was associated with a higher ERB rate and should be considered a short-term temporising strategy when immediate definitive coverage is not feasible, and only within a controlled Role IV environment. Early definitive soft-tissue or muscle coverage remains the preferred protective strategy whenever feasible.
C1 [Sivash, Iurii; Koval, Boris] Bogomolets Natl Med Univ, Kiev, Ukraine.
   [Sivash, Iurii; Koval, Boris] Main Mil Clin Hosp, Natl Mil Med Clin Ctr, Dept Vasc Surg, Kiev, Ukraine.
C3 Bogomolets National Medical University
RP Sivash, I (通讯作者)，Bogomolets Natl Med Univ, Kiev, Ukraine.; Sivash, I (通讯作者)，Main Mil Clin Hosp, Natl Mil Med Clin Ctr, Dept Vasc Surg, Kiev, Ukraine.
EM y.sivash@gmail.com; kovalboris@gmail.com
CR Älgå A, 2020, LANCET GLOB HEALTH, V8, pE423, DOI 10.1016/S2214-109X(19)30547-9
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2633-3767
EI 2633-3775
J9 BMJ MILITARY HEALTH
JI BMJ Military Health
PD 2026 MAR 25
PY 2026
DI 10.1136/military-2025-003192
EA MAR 2026
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FV1LT
UT WOS:001728132900001
PM 41881513
OA hybrid
DA 2026-07-24
ER
PT J
AU Chen, GW
   Lan, XX
   Li, F
   Zeng, DY
   Wang, LH
   Chen, XY
   Zhu, L
AF Chen, Guowei
   Lan, Xiaoxu
   Li, Fang
   Zeng, Deyuan
   Wang, Luhong
   Chen, Xiaoyu
   Zhu, Li
TI Peristomal pyoderma gangrenosum: a review of nursing research progress
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE immunosuppressive treatment; negative pressure wound therapy; ostomy
   complications; peristomal pyoderma gangrenosum; wound nursing
ID MANAGEMENT; DIAGNOSIS; DISEASE
AB Peristomal pyoderma gangrenosum (PPG) is a rare and therapeutically challenging inflammatory dermatosis predominantly affecting individuals with stoma surgery. This review provides a comprehensive overview of PPG, encompassing its etiology, clinical manifestations, diagnostic methods, treatment strategies, and nursing management. PPG's multifactorial etiology involves immune dysfunction, genetic predisposition, surgical trauma, and demographic factors, which contribute to the formation of painful ulcers that significantly impair patients' quality of life. Accurate diagnosis requires a multidisciplinary approach, including clinical evaluation, histopathological examination, and advanced diagnostic criteria. Effective management combines local wound care, systemic therapies, and surgical interventions, emphasizing a patient-centered and evidence-based approach. Nursing strategies, including advanced wound care, pain management, psychological support, nutritional interventions, and health education, play a vital role in optimizing outcomes and preventing recurrence. Future research should focus on the development of specific biomarkers, novel therapeutic agents, and standardized nursing protocols to address the unmet needs in PPG care. This integrated diagnostic, therapeutic, and nursing framework aims to enhance patient outcomes and provide insights for future clinical and research advancements.
C1 [Chen, Guowei; Li, Fang; Zeng, Deyuan; Wang, Luhong; Zhu, Li] Chongqing Gen Hosp, Dept Gen Surg, Chongqing, Peoples R China.
   [Lan, Xiaoxu] Chongqing Gen Hosp, Dept Hemodialysis, Chongqing, Peoples R China.
   [Chen, Xiaoyu] Xipeng Town Hlth Ctr, Dept Nursing, Chongqing, Peoples R China.
RP Zhu, L (通讯作者)，Chongqing Gen Hosp, Dept Gen Surg, Chongqing, Peoples R China.
EM 709522592@qq.com
RI zeng, deyuan/KTI-7517-2024
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NR 38
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 16
PY 2026
VL 13
AR 1774931
DI 10.3389/fmed.2026.1774931
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FV6ZQ
UT WOS:001728508100001
PM 41919168
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Li, M
   Wu, F
   Du, J
   Ding, Y
   Zhang, B
   Ding, K
AF Li, Meng
   Wu, Fan
   Du, Jun
   Ding, Yang
   Zhang, Bei
   Ding, Kang
TI Combination Therapy of Vacuum Sealing Drainage and Counter-Current
   Irrigation for Refractory Perianal Wounds
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID DRESSINGS
AB Perianal refractory wounds refer to long-term non-healing wounds of the skin and soft tissues surrounding the anus, often resulting from surgery or complications of chronic diseases. Current treatment mainly focuses on maintaining an open wound environment and allowing healing to follow its natural course. Due to the specific anatomical location, susceptibility to secondary infection, and the local wound environment, healing often requires more than 4 weeks. Vacuum-sealed drainage (VSD), combined with counter-current irrigation technology, has been widely adopted and demonstrated significant efficacy in specialties such as burn and plastic surgery, orthopedics, and general surgery. This non-invasive negative-pressure technology offers new approaches for treating refractory perianal wounds, promoting active intervention in the healing process, accelerating healing speed, improving healing quality, and reducing patient discomfort. This article describes the management and application details of this technology for refractory perianal wounds, including methods of outer-film application at different positions, differences in negative-pressure settings based on wound distance from the anal margin, and strategies to avoid secondary contamination. This methodology may facilitate broader clinical adoption of VSD for perianal refractory wounds and presents new therapeutic opportunities for managing such challenging non-healing wounds.
C1 [Li, Meng; Wu, Fan; Ding, Yang; Zhang, Bei; Ding, Kang] Nanjing Univ Chinese Med, Nanjing Hosp Chinese Med, Nanjing, Peoples R China.
   [Du, Jun] Nanjing Univ Chinese Med, Suzhou Tradit Chinese Med Hosp, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Li, M; Ding, K (通讯作者)，Nanjing Univ Chinese Med, Nanjing Hosp Chinese Med, Nanjing, Peoples R China.
EM limeng740316@163.com; fsyy00237@njucm.edu.cn
FU Planning and Finance Department Project of the National Administration
   of Traditional Chinese Medicine [GZY-GCS-2025-006]; Jiangsu Provincial
   Center for T.C.M. Innovations; Jiangsu Administration of Chinese
   Medicine
FX Financial support for this study was provided by the Planning and
   Finance Department Project of the National Administration of Traditional
   Chinese Medicine (Grant No. GZY-GCS-2025-006). Additional support was
   received from the Jiangsu Provincial Center for T.C.M. Innovations and
   the Jiangsu Administration of Chinese Medicine.
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NR 34
TC 0
Z9 0
U1 1
U2 1
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD MAR
PY 2026
IS 229
AR e69888
DI 10.3791/69888
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FZ9KT
UT WOS:001731384200005
PM 41941407
DA 2026-07-24
ER
PT J
AU Misticoni, F
   Chiavaroli, V
   Cauzzo, C
   Fornaro, DS
   Miscia, ME
   Fusillo, M
   Lisi, G
   Chiarelli, F
   Di Valerio, S
AF Misticoni, Francesco
   Chiavaroli, Valentina
   Cauzzo, Chiara
   Fornaro, Davide Scarponcini
   Miscia, Maria Enrica
   Fusillo, Mario
   Lisi, Gabriele
   Chiarelli, Francesco
   Di Valerio, Susanna
TI Case Report: Staged surgical repair and negative pressure wound therapy
   in congenital omphalocele
SO FRONTIERS IN PEDIATRICS
LA English
DT Article
DE congenital disorders; negative pressure wound therapy; newborn;
   omphalocele; surgical procedures
ID VACUUM-ASSISTED CLOSURE; GIANT OMPHALOCELES; MANAGEMENT; EXOMPHALOS
AB Background Omphalocele is a congenital abdominal wall defect that causes the protrusion of the abdominal organs at the base of the umbilical cord, which is covered by a membranous sac composed of the peritoneum and amnion. We report the case of a newborn with a giant omphalocele containing the liver and bowel loops who underwent staged surgical closure followed by negative pressure wound therapy (NPWT) for the management of skin wound dehiscence.Case presentation A male Caucasian infant was born at 35 weeks by elective cesarean section due to a prenatal diagnosis of a giant omphalocele. The clinical examination at birth confirmed a giant omphalocele with extensive liver and small bowel content. Cardio-respiratory and neurological examinations were unremarkable. The omphalocele was initially wrapped with hydrocolloid dressings. After bowel content reduction and epithelialization of the membrane, a three-stage surgery was scheduled as follows: first, a silo bag was fashioned (on day 22); then, after complete liver reduction, the wide muscle-fascial defect was temporarily covered by a porcine dermal implant to close the gap (on day 32); finally, the abdominal wall was fully closed without prosthetic material using the component separation method (on day 68). NPWT was performed in two stages for a total of 29 days. The first period, applied between the second and third interventions, began on day 37 and continued for 16 days. Due to partial dehiscence of the surgical wound, NPWT was restarted on day 75 for 13 days, with increasing pressure (from -20 to -40 mmHg). Progressive improvement of the wound was obtained. After NPWT removal, an antimicrobial hydro-balanced dressing was placed on the wound.Conclusions This case underlines the lack of a standardized therapeutic approach for complex abdominal wall defects. It also highlights the efficacy of NPWT in complicated surgical wounds in infancy, given the reduction in dressing frequency and related stress. Furthermore, NPWT guarantees a significant reduction in the number of days required for the resolution of the surgical wound.
C1 [Misticoni, Francesco] G Dannunzio Univ Chieti & Pescara, Dept Pediat, Chieti, Italy.
   [Chiavaroli, Valentina; Cauzzo, Chiara; Fornaro, Davide Scarponcini; Di Valerio, Susanna] Santo Spirito Hosp, Neonatal Intens Care Unit, Pescara, Italy.
   [Miscia, Maria Enrica; Fusillo, Mario; Lisi, Gabriele] Santo Spirito Hosp, Pediat Surg Unit, Pescara, Italy.
   [Lisi, Gabriele; Chiarelli, Francesco] G Dannunzio Univ Chieti & Pescara, Dept Med & Aging Sci, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara
RP Chiavaroli, V (通讯作者)，Santo Spirito Hosp, Neonatal Intens Care Unit, Pescara, Italy.
EM valentina.chiavaroli@asl.pe.it
RI Chiavaroli, Valentina/ABB-1911-2020
FU Lohmann & Rauscher GmbH Co.
FX The author(s) declared that financial support was received for this work
   and/or its publication. The Article Processing Charge (APC) was funded
   by Lohmann & Rauscher GmbH & Co. KG. The funder had no role in study
   design, data collection, analysis, interpretation of data, writing of
   the manuscript, or decision to publish.
CR Abello C, 2021, J PEDIATR SURG, V56, P1068, DOI 10.1016/j.jpedsurg.2020.12.003
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NR 21
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2360
J9 FRONT PEDIATR
JI Front. Pediatr.
PD MAR 18
PY 2026
VL 14
AR 1771958
DI 10.3389/fped.2026.1771958
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA GA3ZK
UT WOS:001731693600001
PM 41929918
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Pathinathan, K
   Sial, A
   Khalil, O
   Ghahreman, A
   Diwan, A
AF Pathinathan, Kalaventhan
   Sial, Alisha
   Khalil, Osama
   Ghahreman, Ali
   Diwan, Ashish
TI Strategies to prevent post-operative surgical site infection in spinal
   surgery: a narrative review
SO EUROPEAN SPINE JOURNAL
LA English
DT Review
DE Postoperative spine infections; Prevention of postoperative spine
   infections; Multidisciplinary approach; Risk factors of post-operative
   spine infections
ID RISK
AB Background Post-operative surgical site infections (SSIs) remain a major source of morbidity following spinal surgery, contributing to prolonged hospitalisations, re-operation, implant failure and increased healthcare costs. Despite advances in surgical technique and peri-operative care, SSI prevention in spine surgery remains challenging. Objective To provide a narrative synthesis of contemporary evidence relating to the prevention of SSIs in spinal surgery across the pre-operative, intra-operative, and post-operative phases, with additional emphasis on emerging and translational technologies. Methods A structured literature review of MEDLINE/PubMed (1990-2024) was performed. Systematic reviews, randomized controlled trials, high-quality cohort studies, and major international guideline statements were selectively included to synthesise current preventive strategies in spinal surgery. Results SSI prevention in spinal surgery requires a multimodal peri-operative strategy. Pre-operative optimisation includes smoking cessation, glycaemic control, nutritional assessment, anaemia correction, and targeted Staphylococcus aureus screening and decolonisation. Intra-operative measures supported by moderate-to-high-quality evidence include chlorhexidine-alcohol skin preparation, weight-adjusted antibiotic prophylaxis with appropriate re-dosing, dilute povidone-iodine irrigation, meticulous tissue handling, and intrawound vancomycin powder in selected high-risk posterior instrumented cases. Post-operative interventions such as extended occlusive dressings, silver-impregnated dressings, and prophylactic negative-pressure wound therapy may reduce SSI risk in high-risk populations. Prolonged post-operative antibiotic administration beyond 24 h has not demonstrated additional benefit and may increase antimicrobial resistance. Emerging technologies targeting biofilm formation and antimicrobial resistance represent promising future directions. Conclusions Preventing SSIs in spinal surgery requires an integrated peri-operative approach informed by evolving evidence. While several strategies are supported by consistent data, significant gaps remain, particularly regarding emerging technologies. Ongoing high-quality clinical studies are needed to refine SSI prevention frameworks in spine surgery.
C1 [Pathinathan, Kalaventhan; Sial, Alisha; Khalil, Osama; Ghahreman, Ali; Diwan, Ashish] UNSW Sydney, Sydney, Australia.
RP Diwan, A (通讯作者)，UNSW Sydney, Sydney, Australia.
EM kalaventhansurgery@gmail.com; a.sial@unsw.edu.au;
   fellow@spine-service.org; draghahreman@gmail.com; a.diwan@unsw.edu.au
RI ; Diwan, Ashish/OPN-6729-2025; Pathinathan, Kalaventhan/ABQ-1538-2022
OI Khalil, Osama/0009-0002-8977-7520; 
FU University of New South Wales
FX Open Access funding enabled and organized by CAUL and its Member
   Institutions
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NR 44
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0940-6719
EI 1432-0932
J9 EUR SPINE J
JI Eur. Spine J.
PD JUL
PY 2026
VL 35
IS 7
SI SI
BP 4198
EP 4206
DI 10.1007/s00586-026-09911-3
EA APR 2026
PG 9
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA LD5QZ
UT WOS:001733037900001
PM 41936664
OA hybrid
DA 2026-07-24
ER
PT J
AU Karadeniz, O
   Guler, OM
   Tunc, B
   Goksu, M
AF Karadeniz, Ozan
   Guler, Osman Murat
   Tunc, Bugra
   Goksu, Mustafa
TI Negative pressure wound therapy versus conventional debridement in
   subcutaneous abdominal wound healing in obese patients following
   obstetric/gynaecologic surgery
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE abdominal wound dehiscence; gynaecology; negative pressure wound
   therapy; obstetrics; subcutaneous abdominal wound healing impairment;
   surgical site infection; vacuum-assisted closure; wound care; wound
   dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; SURGICAL-SITE INFECTION; MANAGEMENT; TRIAL;
   RISK; NPWT
AB Objective: This study evaluates the clinical outcomes of negative pressure wound therapy plus debridement (NPWT+D) compared to conventional debridement (CD) in cases of subcutaneous abdominal wound healing impairment (SAWHI) following obstetric and gynaecological surgery. Method: This retrospective cohort study examined data from patients with obesity (body mass index >= 30kg/m2) who experienced SAWHI after surgical site infections following obstetric and gynaecological procedures. Patients were divided into two groups according to treatment methods: the control group received standard care with debridement alone (CD group), while the remainder received NPWT+D (NPWT+D group). Data were collected from patient medical records, focusing on: demographic factors; comorbidities; wound characteristics; perioperative data; wound healing; hospital stay; intravenous treatment; infection rates; and dressing counts. Results: The data of 103 patients were reviewed. The NPWT+D group (n=50) demonstrated shorter wound healing times than the CD group (n=53) (11.3 +/- 4.2 days versus 14.9 +/- 6.4 days, respectively; p=0.004) and markedly fewer debridement sessions (3.7 +/- 1.5 versus 14.5 +/- 5.9, respectively; p<0.001). Additionally, reinfection rates were significantly lower in the NPWT+D group compared with the CD group (4.0% versus 24.5%, respectively; p=0.003). Conclusion: The findings of this retrospective study showed that NPWT, when integrated with surgical debridement, demonstrated significant efficacy in managing SAWHI following obstetric and gynaecological procedures. Compared to CD, NPWT+D was associated with accelerated wound healing and decreased frequency of dressing changes, thereby minimising patient discomfort and healthcare resource use. Declaration of interest: The authors have no conflicts of interest to declare.
C1 [Karadeniz, Ozan; Guler, Osman Murat; Tunc, Bugra] Basaksehir Cam & Sakura City Hosp, Dept Gynecol & Obstet, Istanbul, Turkiye.
   [Goksu, Mustafa] Univ Hlth Sci, Kanuni Sultan Suleyman Training & Res Hosp, Dept Gynecol & Obstet, Istanbul, Turkiye.
C3 University of Health Sciences Turkey; Istanbul Kanuni Sultan Suleyman
   Training & Research Hospital
RP Karadeniz, O (通讯作者)，Basaksehir Cam & Sakura City Hosp, Dept Gynecol & Obstet, Istanbul, Turkiye.
EM dr.ozankrdnz@gmail.com
RI Karadeniz, Ozan/JAX-6703-2023; Göksu, Mustafa/ISA-2515-2023
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NR 45
TC 1
Z9 1
U1 1
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2026
VL 35
IS 4
SU A
BP S18
EP S26
DI 10.12968/jowc.2025.0021
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GF4YA
UT WOS:001735156000001
PM 41926571
DA 2026-07-24
ER
PT J
AU Ragonese, A
   Malan, F
   Festa, P
   Giudice, G
   Papa, G
   Ciliberti, M
   Sciuto, A
   Sciattella, P
AF Ragonese, Angela
   Malan, Fabrizio
   Festa, Patrizio
   Giudice, Giuseppe
   Papa, Giovanni
   Ciliberti, Marino
   Sciuto, Antonio
   Sciattella, Paolo
TI Cost of treatment of hard-to-heal wounds in Italy: a study on real-world
   data
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE continuity of care; cost of illness; dwell; hard-to-heal; health
   economics; instillation; negative pressure wound therapy; NPWTi-d;
   wound; wound care; wound dressing; wound healing
ID INSTILLATION THERAPY; SALINE; MANAGEMENT; DEVICES; RISK; CARE
AB Objective: To assess the clinical effectiveness and cost benefits of negative pressure wound therapy with instillation and dwell (NPWTi-d) compared to standard NPWT and other therapies in managing hard-to-heal wounds. Method: An observational, retrospective, multicentre study was conducted using data from three hospitals in Italy. Eligible patients included all adults discharged in 2021 with specific diagnoses related to hard-to-heal wounds. Data on healthcare resource use, including length of hospital stay (LoS), number of dressings used and procedures performed, were analysed. The economic evaluation estimated hospitalisation costs based on the average daily rate. The analysis findings were further examined in an expert meeting focused on assessing the impact of continuity of care pathways on treatment outcomes. Results: A total of 64 patients were enrolled: 38 received NPWT; 16 received NPWTi-d; and 10 received other treatments, including traditional and advanced wound care approaches. The NPWTi-d group demonstrated a significantly shorter average LoS (13.4 days) compared to the NPWT (23.6 days) and other treatments (21.5 days) groups. Patients receiving NPWTi-d also had fewer dressing changes (2.6) than those treated with NPWT (3.5) and other therapies (6.6). This reduction in resource consumption translates to cost savings of >& euro;6000 (-35.1%) per hospitalisation compared to the overall average hospitalisation cost across the study sample and & euro;7645 (-40.7%) compared to other treatments. The findings were confirmed during the expert meeting. Conclusion: As shown by the findings of this study, by improving patient outcomes and reducing the burden on healthcare systems, NPWTi-d should be considered a key component in modern wound care pathways. Its implementation aligns with current healthcare initiatives focused on optimising resource use and improving patient quality of life. Declaration of interest: This study was funded by Solventum, Milan, Italy, which is a manufacturer of medical devices, including NPWT systems. Solventum provided funding only and had no involvement in study design, data collection, analysis, manuscript writing, or the decision to publish. The authors have no conflicts of interest to declare.
C1 [Ragonese, Angela; Sciattella, Paolo] Univ Roma Tor Vergata, Econ Evaluat & HTA EEHTA CEIS, Rome, Italy.
   [Malan, Fabrizio] CTO Hosp, Citta Salute & Sci, Plast Surg Dept, Turin, Italy.
   [Festa, Patrizio] Cardarelli Hosp, Trauma Ctr Dept, Naples, Italy.
   [Giudice, Giuseppe] Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Div Plast & Reconstruct Surg, Bari, Italy.
   [Papa, Giovanni] ASUGI Azienda Sanitaria Univ Giuliano Isontina, Osped Cattinara, Plast Surg Dept, Trieste, Italy.
   [Ciliberti, Marino] Ctr Aziendale Riparaz Tissutale, Wound Care Ctr, Castellammare Di Stabia, Italy.
   [Sciuto, Antonio] Cardarelli Hosp, Dept Gen Surg, Naples, Italy.
C3 University of Rome Tor Vergata; A.O.U. Citta della Salute e della
   Scienza di Torino; Antonio Cardarelli Hospital; Universita degli Studi
   di Bari Aldo Moro; Antonio Cardarelli Hospital
RP Ragonese, A (通讯作者)，Univ Roma Tor Vergata, Econ Evaluat & HTA EEHTA CEIS, Rome, Italy.
EM angelaragonese@gmail.com
CR Andrianello S, 2021, SURGERY, V169, P1069, DOI 10.1016/j.surg.2020.10.029
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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   Chowdhry SA, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002087
   Collinsworth AW, 2022, WOUNDS, V34, P269, DOI 10.25270/wnds/22013
   Crumley C, 2021, J WOUND OSTOMY CONT, V48, P199, DOI 10.1097/WON.0000000000000760
   De Pellegrin L, 2023, INT WOUND J, V20, P2402, DOI 10.1111/iwj.14072
   Diehm YF, 2021, PLAST RECONSTR SURG, V147, p43S, DOI 10.1097/PRS.0000000000007610
   Eurostat, HEALTHCARE EXPENDITU
   Faust E, 2021, PLAST RECONSTR SURG, V147, p16S, DOI 10.1097/PRS.0000000000007607
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   Gabriel A, 2012, INT WOUND J, V9, P25, DOI 10.1111/j.1742-481X.2012.01014.x
   Giri P, 2021, ANN MED SURG, V61, P73, DOI 10.1016/j.amsu.2020.12.015
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NR 35
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2026
VL 35
IS 4
BP 342
EP 348
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GF4ZE
UT WOS:001735159000001
PM 41926470
DA 2026-07-24
ER
PT J
AU Portou, M
   Bernaerts, K
   Bassetto, F
   Cherubino, M
   Collier, M
   Hirche, C
   Horch, RE
   Mall, JW
   O'Brien, G
   Piaggesi, A
   Porter, C
   Probst, S
   Rashid, ST
   Trivedi, S
AF Portou, Mark
   Bernaerts, Kris
   Bassetto, Franco
   Cherubino, Mario
   Collier, Mark
   Hirche, Christoph
   Horch, Raymund E.
   Mall, Julian W.
   O'Brien, Gillian
   Piaggesi, Alberto
   Porter, Claire
   Probst, Sebastian
   Rashid, S. Tawqeer
   Trivedi, Sadhana
TI Negative pressure wound therapy made simple: expert panel
   recommendations
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE algorithm; negative pressure wound therapy; negative pressure wound
   therapy with instillation; NPWT; NPWTi-d; single-use NPWT system; sNPWT;
   wound; wound care; wound dressing; wound healing
ID INSTILLATION
AB Objective: Wound management poses a substantial economic burden, and the prevalence of hard-to-heal (chronic) wounds is a growing health concern. Negative pressure wound therapy (NPWT), with and without instillation, is an adjunctive therapy commonly used to manage acute and hard-to-heal wounds and has demonstrated positive clinical outcomes. The variety of NPWT modalities, patient needs, wound characteristics and care requirements can make selecting the optimal system challenging, leading to uncertainty and inconsistent practices among new users, increasing the risk of suboptimal outcomes. This article provides practical guidance to help new NPWT users make confident, evidence-based decisions. Method: An expert panel was convened in Amsterdam, the Netherlands, in November 2023 to review published treatment guidelines and the current literature and to develop simplified recommendations on the use of NPWT in hospital and community care settings. Results: Expert panel members discussed published wound management evidence and their real-world experiences as wound management specialists to generate recommendations for healthcare professionals to aid them in the selection of NPWT modalities. Conclusion: This summary presents nine expert panel recommendations, including simplified risk assessment algorithms and guidance to improve NPWT use across clinical settings. Declaration of interest: ST is an employee of Solventum. All other authors have consulting agreements with Solventum. Funding for the advisory panel meeting was provided by Solventum. The authors have no other conflicts of interest to declare.
C1 [Portou, Mark] Royal Free London NHS Fdn Trust, London, England.
   [Bernaerts, Kris] Univ Hosp Leuven, Leuven, Belgium.
   [Bassetto, Franco] Univ Padua, Clin Plast & Reconstruct Surg, Padua, Italy.
   [Cherubino, Mario] Cleveland Clin Abu Dhabi, Abu Dhabi, U Arab Emirates.
   [Collier, Mark] Tissue Viabil, Lincoln, Lincs, England.
   [Collier, Mark] Univ Lincoln, Lincoln, England.
   [Hirche, Christoph] Goethe Univ Frankfurt, BG Unfallklin Frankfurt am Main, Frankfurt, Germany.
   [Horch, Raymund E.] Univ Hosp Erlangen, Erlangen, Bavaria, Germany.
   [Mall, Julian W.] Klinikum Reg Hannover, Hannover, Germany.
   [O'Brien, Gillian] Naas Gen Hosp, Naas, Kildare, Ireland.
   [Piaggesi, Alberto] Univ Pisa, Pisa, Italy.
   [Porter, Claire] Univ Hosp Leicester, Leicester, England.
   [Probst, Sebastian] HES SO Univ Appl Sci & Arts Western Switzerland, Geneva, Switzerland.
   [Rashid, S. Tawqeer] Manchester Univ Hosp NHS Fdn Trust, Manchester, England.
   [Trivedi, Sadhana] Solventum, Med Surg, Dublin, Ireland.
C3 University of London; University College London; Royal Free London NHS
   Foundation Trust; KU Leuven; University Hospital Leuven; University of
   Padua; Cleveland Clinic Foundation; University of Lincoln; Goethe
   University Frankfurt; University of Erlangen Nuremberg; University of
   Pisa; University of Leicester; University Hospitals of Leicester NHS
   Trust; University of Applied Sciences & Arts Western Switzerland;
   Wythenshawe Hospital NHS Foundation Trust
RP Portou, M (通讯作者)，Royal Free London NHS Fdn Trust, London, England.
EM m.portou@nhs.net
RI Probst, Sebastian/AAN-6968-2020; Horch, Raymund/H-8128-2019; Cherubino,
   Mario/N-1780-2019; Rashid, T/B-9474-2008
OI Probst, Sebastian/0000-0001-9603-1570; 
FX Acknowledgements The authors would like to thank Matthew Cooper and
   Christian Seelandt (Solventum) for their participation in the expert
   panel, and to thank Maritza Quintero, Ashley Collinsworth, Julissa Ramos
   and Ricardo R Martinez (Solventum) for their assistance with manuscript
   preparation and editing.
CR Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
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   Bassetto F, 2012, J PLAST RECONSTR AES, V65, P91, DOI 10.1016/j.bjps.2011.08.016
   Bernstein BH, 2005, WOUNDS, V17, P37
   Bradbury S, 2015, ADV WOUND CARE, V4, P346, DOI 10.1089/wound.2014.0596
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   Collinsworth AW, 2022, WOUNDS, V34, P269, DOI 10.25270/wnds/22013
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   Gabriel A, 2021, PLAST RECONSTR SURG, V147, p68S, DOI 10.1097/PRS.0000000000007614
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   Kim PJ, 2018, WOUNDS, pS1
   Lim K, 2020, INT WOUND J, V17, P531, DOI 10.1111/iwj.13307
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   Tettelbach W, 2019, WOUNDS
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NR 35
TC 0
Z9 0
U1 1
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2026
VL 35
IS 4
BP 292
EP 298
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GF4ZS
UT WOS:001735160400001
PM 41926464
DA 2026-07-24
ER
PT J
AU Regan, MD
   Freeman, CM
   Talathi, N
   Spiegel, DA
   Flynn, JM
   Baldwin, KD
AF Regan, Maia D.
   Freeman, Colby M.
   Talathi, Nakul
   Spiegel, David A.
   Flynn, John M.
   Baldwin, Keith D.
TI Sealing the Deal: Incisional Vacuum Assisted Closure Following
   Neuromuscular Posterior Spinal Fusion is Associated With a Lower Rate of
   Infection
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE spine; neuromuscular; infections; scoliosis
ID PRESSURE WOUND THERAPY; SCOLIOSIS SURGERY; RISK-FACTORS
AB Background: Surgical site infection (SSI) after posterior spinal fusion (PSF) to correct neuromuscular scoliosis is a devastating complication in pediatric patients. Incisional Vacuum-Assisted Closure (iVAC) is a method used for wound management, especially in high-risk surgical wounds. Pediatric neuromuscular patients are at high risk for infection or wound complications following spinal deformity correction. The goal of this study was to evaluate the effectiveness of iVAC therapy after PSF in pediatric neuromuscular scoliosis in preventing wound dehiscence and SSI as measured by the metric of unplanned return to the OR for infection in <90 days from the date of surgery. Methods: We reviewed all nonambulatory patients with neuromuscular scoliosis who underwent PSF at a single, large tertiary care pediatric hospital from 2019 to 2024. Ambulatory patients with neuromuscular disease were excluded. During this period of time, a consistent SSI prevention protocol was active and remained similar for all spine surgeons at our institution. Patients were placed into 1 of 2 groups based on whether they had an iVAC placed at the index procedure, and postoperative outcomes were examined. Results: A total of 134 patients [71 (53%) male and 63 (47%) female] with a mean age of 13.5 +/- 3.1 years at the time of surgery were included. Unplanned return to the operating room (UPROR) for suspected infection (<90 d) occurred among 7 (7.3%) patients with iVAC versus 8 (21.0%) without. UPROR was 2.9 times higher without iVAC (P=0.023). Only one (2.2%) patient faced infection among those sent home with the iVAC [P=0.020 (vs. either iVAC in the hospital or no iVAC)]. The number needed to treat with iVAC treatment to prevent one UPROR was 7.3. Conclusion: iVAC is a clinically useful, low-cost, low-morbidity tool in the fight against NM infection. Any duration of use of the iVAC following neuromuscular PSF appears to be associated with a lower incidence of infection.
C1 [Regan, Maia D.; Freeman, Colby M.; Talathi, Nakul; Spiegel, David A.; Flynn, John M.; Baldwin, Keith D.] Childrens Hosp Philadelphia, Orthopaed Ctr, 3401 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of
   Philadelphia
RP Baldwin, KD (通讯作者)，Childrens Hosp Philadelphia, Orthopaed Ctr, 3401 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
EM Maia.Regan@quinnipiac.edu; freemanc4@chop.edu; nstalathi@gmail.com;
   spiegeld@chop.edu; flynnj@chop.edu; baldwink@email.chop.edu
RI Freeman, Colby/NLO-5973-2025
OI Freeman, Colby/0009-0004-1407-5641
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
   Aleissa S, 2011, CAN J SURG, V54, P263, DOI 10.1503/cjs.008210
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   Badin D, 2023, JBJS OPEN ACCESS, V8, DOI 10.2106/JBJS.OA.22.00123
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   Clark CE, 1999, SPINE, V24, P1909, DOI 10.1097/00007632-199909150-00008
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-6798
EI 1539-2570
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD MAY-JUN
PY 2026
VL 46
IS 5
BP e475
EP e479
DI 10.1097/BPO.0000000000003220
PG 5
WC Orthopedics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Pediatrics
GA GF6ED
UT WOS:001735239900017
PM 41556273
DA 2026-07-24
ER
PT J
AU Seong, BO
   Ahn, JY
   Yoo, J
   Ko, CS
   Min, SH
   Gong, CS
   Kim, BS
   Yoo, MW
   Yook, JH
   Choi, HJ
   Lee, IS
AF Seong, Ba Ool
   Ahn, Ji Yong
   Yoo, Juno
   Ko, Chang Seok
   Min, Sa-Hong
   Gong, Chung Sik
   Kim, Beom Su
   Yoo, Moon-Won
   Yook, Jeong Hwan
   Choi, Hee Jin
   Lee, In-Seob
TI Defect Size-Based Comparative Analysis of Treatment Modalities for
   Esophagojejunal Anastomotic Leakage Following Gastrectomy
SO JOURNAL OF GASTRIC CANCER
LA English
DT Article
DE Anastomotic leak; Gastrectomy; Treatment outcome; Conservative treatment
ID RISK-FACTORS; MANAGEMENT; RESECTION; ADENOCARCINOMA; SURVIVAL; JUNCTION;
   OUTCOMES; THERAPY; IMPACT
AB Purpose: Esophagojejunal anastomotic leakage (EJAL) represents a severe postoperative complication following total or proximal gastrectomy. Treatment strategies include conservative management, endoscopic interventions, and surgery; however, comparative data remain limited. This study aimed to compare clinical outcomes of different strategies to identify the optimal approach based on anastomotic defect size. Materials and Methods: This retrospective study reviewed 100 patients diagnosed with EJAL between January 2015 and October 2024. Patients were categorized into four groups: conservative management, endoscopic vacuum-assisted closure (E-VAC), other endoscopic treatments, and surgery. The primary outcomes were leakage duration and length of hospital stay after EJAL diagnosis, whereas the secondary outcome was time to C-reactive protein normalization. Subgroup analyses were performed according to defect size. Results: Among the 100 patients, 76 were male and 24 were female, with a mean age of 65.7 years. Conservative treatment was the most common modality (53%), followed by other endoscopic treatments (19%), E-VAC (14%), and surgery (14%). In patients with a defect size <1 cm, conservative treatment was associated with significantly shorter leakage duration (P=0.035) and earlier resumption of diet (P=0.029) compared with endoscopic treatment. Among those with defects >= 2 cm, E-VAC demonstrated the most favorable median outcomes across all variables; however, statistical significance was not achieved because of the small sample size. Conclusions: Conservative treatment appears to be the most effective treatment strategy for EJAL with anastomotic defects <1 cm. For larger defects (>= 2 cm), E-VAC may offer clinical benefit, although further studies are needed to confirm its efficacy. These findings highlight the importance of individualized treatment selection based on defect size.
C1 [Seong, Ba Ool; Yoo, Juno; Ko, Chang Seok; Min, Sa-Hong; Gong, Chung Sik; Kim, Beom Su; Yoo, Moon-Won; Yook, Jeong Hwan; Lee, In-Seob] Univ Ulsan, Asan Med Ctr, Div Gastrointestinal Surg, Dept Surg,Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
   [Seong, Ba Ool; Ahn, Ji Yong] Dongnam Inst Radiol & Med Sci, Canc Ctr, Dept Surg, Div Gastrointestinal Surg, Busan, South Korea.
   [Ahn, Ji Yong] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea.
   [Choi, Hee Jin] Asan Med Ctr, Dept Clin Epidemiol & Biostat, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; Korea Institute of
   Radiological & Medical Sciences; University of Ulsan; Asan Medical
   Center; University of Ulsan; Asan Medical Center
RP Lee, IS (通讯作者)，Univ Ulsan, Asan Med Ctr, Div Gastrointestinal Surg, Dept Surg,Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
EM inseoblee77@gmail.com
RI Gong, chung sik/JCD-7106-2023; Ahn, Ji Yong/AGO-1695-2022
OI Ahn, Ji Yong/0000-0002-0030-3744
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [RS-2023-KH140182]
FX Funding This research was supported by a grant of the Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute (KHIDI) , funded by the Ministry of Health & Welfare, Republic
   of Korea (grant number: RS-2023-KH140182)
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU KOREAN GASTRIC CANCER ASSOC
PI SEOUL
PA GWANGHWAMUN OPCIA BLDG 1616, 163 SINMUN-RO 1-GA, JONGNO-GU, SEOUL,
   110-999, SOUTH KOREA
SN 2093-582X
EI 2093-5641
J9 J GASTRIC CANCER
JI J. Gasric Cancer
PD APR
PY 2026
VL 26
IS 2
BP 295
EP 306
DI 10.5230/jgc.2026.26.e20
PG 12
WC Oncology; Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Gastroenterology & Hepatology
GA GG1IW
UT WOS:001735590900012
PM 41942361
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Du, H
   Jiang, T
   Mao, RQ
   Yang, XF
   Chen, ZB
AF Du, Hai
   Jiang, Tao
   Mao, Renqun
   Yang, Xiaofan
   Chen, Zhenbing
TI The Role of Negative Pressure Therapy in Diabetic Foot Ulcer: A
   Meta-Analysis
SO JOURNAL OF DIABETES
LA English
DT Review
DE amputation; diabetic foot ulcer; meta-analysis; negative pressure wound
   therapy; wound healing rate
ID WOUND THERAPY; MULTICENTER
AB Diabetic foot ulcer (DFU) is a severe complication, often leading to amputation. Negative pressure wound therapy (NPWT) is an advanced treatment option requiring further consolidated evidence. This study evaluated the effectiveness and safety of NPWT versus conventional wound care for DFU, focusing on wound healing, amputation prevention, and adverse events (AEs). We systematically searched PubMed, Cochrane Library, Embase, and Web of Science for randomized controlled trials (RCTs) from inception until October 2025. Twenty-three RCTs involving 2086 participants were included. Two reviewers independently selected studies. Outcomes included wound healing rate, ulcer area reduction, amputation rate, and adverse events. Pooled odds ratios (OR) and standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using random-effects models. NPWT significantly improved the wound healing rate (OR 4.48, 95% CI 2.58-7.77), led to a greater reduction in ulcer area (SMD 1.26, 95% CI 0.70-1.82), and substantially lowered amputation risk (OR 0.35, 95% CI 0.19-0.64) compared to conventional care. No significant difference was found in adverse events (OR 0.98, 95% CI 0.56-1.71). Subgroup analyses confirmed benefits across ages, follow-up durations, and control dressings. The healing benefit was most pronounced in less severe ulcers (Wagner grade < 2), while amputation protection was consistent across severities. NPWT is an effective and safe strategy for DFU, significantly accelerating wound healing and reducing amputation risk, supporting its integration as a cornerstone adjunctive therapy.
C1 [Du, Hai; Jiang, Tao; Yang, Xiaofan; Chen, Zhenbing] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hand Surg, Wuhan, Peoples R China.
   [Mao, Renqun] Shenzhen Nanshan Peoples Hosp, Dept Hand & Foot Surg, Shenzhen, Peoples R China.
   [Yang, Xiaofan] Huazhong Univ Sci & Technol, Hubei Key Lab Regenerat Med & Multidisciplinary Tr, Wuhan, Peoples R China.
   [Chen, Zhenbing] Hubei Prov Clin Res Ctr Chron Wound & Diabetic Foo, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Yang, XF; Chen, ZB (通讯作者)，Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hand Surg, Wuhan, Peoples R China.; Yang, XF (通讯作者)，Huazhong Univ Sci & Technol, Hubei Key Lab Regenerat Med & Multidisciplinary Tr, Wuhan, Peoples R China.; Chen, ZB (通讯作者)，Hubei Prov Clin Res Ctr Chron Wound & Diabetic Foo, Wuhan, Peoples R China.
EM 2017xh0119@hust.edu.cn; zbchen@hust.edu.cn
RI du, hai/MVV-7719-2025
OI Du, Hai/0009-0005-6959-8770
FU Medical Science and Technology Research Foundation of Guangdong Province
   [B2024010]; the Health Science and Technology Project of Hubei Province
   [WJ2025Z007]; National Natural Science Foundation of China [82472566,
   82370838]; the Key Research and Development Program of Hubei Province
   [2024BCB039]
FX This work was supported by the National Natural Science Foundation of
   China (grant number 82472566, 82370838), the Health Science and
   Technology Project of Hubei Province (grant number WJ2025Z007), the Key
   Research and Development Program of Hubei Province (grant number
   2024BCB039), and the Medical Science and Technology Research Foundation
   of Guangdong Province (grant number B2024010).
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NR 52
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD APR 8
PY 2026
VL 18
IS 4
AR e70226
DI 10.1111/1753-0407.70226
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GG4JT
UT WOS:001735797500001
PM 41952430
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zheng, JX
   Xie, DN
   Wu, MY
   Xu, HT
   Lin, SY
   Dong, LL
AF Zheng, Jiaxing
   Xie, Danna
   Wu, Minyu
   Xu, Hongtao
   Lin, Siyin
   Dong, Lili
TI Effects of non-pharmacological interventions on ulcer healing in
   patients with diabetic foot: a network meta-analysis of randomized
   controlled trials
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE diabetic foot ulcer; healing rate; healing time; network meta-analysis;
   non-pharmacological intervention; nursing; wound care
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; DOUBLE-BLIND;
   EFFICACY; MULTICENTER; MANAGEMENT; CARE
AB Background Diabetic Foot Ulcers are a serious complication of diabetes, and the clinical treatment is challenging. In this study, network meta-analysis was used to evaluate the effect of different non-drug interventions on Diabetic Foot Ulcer healing and provide evidence to support clinical decision-making. Methods Data sources: 8 databases, including PubMed, Embase, Cochrane, WOS, CNKI, Wanfang Data, CBM, and VIP, were systematically searched. Literature screening: According to the principle of PICOS, two researchers independently screened. Quality evaluation: Two researchers independently used the Cochrane bias risk assessment tool (RoB 2.0) to evaluate the risk of bias. Statistical analysis: by NMA of the random effects model under the framework of frequency. Results A total of 24 randomized controlled trials involving 15 types of interventions were included. The overall quality of the included literature was moderate. The results of NMA showed that Negative Pressure Wound Therapy + Standard Care had the best effect on 12-week healing rate. Compared with Standard Care, Gas Therapy+ Dressing Therapy + Standard Care had the best healing time. Conclusion Negative Pressure Wound Therapy + Standard Care may be more beneficial for improving the 12-week healing rate of Diabetic Foot Ulcer, while Gas Therapy + Dressing Therapy + Standard Care may show potential advantages in shortening healing time. However, these results rely on a limited number of small-sample studies with wide confidence intervals, indicating limited certainty of evidence. Consequently, the SUCRA rankings should be interpreted with caution as they are primarily exploratory; further high-quality RCTs are required to confirm these findings.
C1 [Zheng, Jiaxing; Xie, Danna; Wu, Minyu; Xu, Hongtao; Dong, Lili] Shantou Univ, Med Coll, Affiliated Hosp 2, Shantou, Peoples R China.
   [Zheng, Jiaxing; Xu, Hongtao; Lin, Siyin] Shantou Univ, Med Coll, Shantou, Peoples R China.
   [Lin, Siyin] Shantou Univ, Canc Hosp, Coll Med, Shantou, Peoples R China.
C3 Shantou University; Shantou University; Shantou University
RP Dong, LL (通讯作者)，Shantou Univ, Med Coll, Affiliated Hosp 2, Shantou, Peoples R China.; Lin, SY (通讯作者)，Shantou Univ, Med Coll, Shantou, Peoples R China.; Lin, SY (通讯作者)，Shantou Univ, Canc Hosp, Coll Med, Shantou, Peoples R China.
EM 928840063@qq.com; Dll13531279671@163.com
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NR 70
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 26
PY 2026
VL 17
AR 1811595
DI 10.3389/fendo.2026.1811595
EA MAR 2026
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GG8YG
UT WOS:001736106900001
PM 41970969
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ciuntu, BM
   Ludusanu, A
   Zara, MT
   Corlade-Andrei, M
   Tanevski, A
   Stan, CI
   Chiran, DA
   Vintila, D
   Andronic, D
   Balan, G
AF Ciuntu, Bogdan Mihnea
   Ludusanu, Andreea
   Zara, Mara Teodora
   Corlade-Andrei, Mihaela
   Tanevski, Adelina
   Stan, Cristinel Ionel
   Chiran, Dragos Andrei
   Vintila, Dan
   Andronic, Dan
   Balan, Gheorghe
TI Recurrent Cervical Esophageal Fistula and Retroesophageal Abscess
   Following Surgical Management of Zenker's Diverticulum
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE Zenker's diverticulum; cervical esophageal fistula; extraluminal VAC;
   vacuum-assisted closure; minimally invasive therapy
AB Background: Zenker's diverticulum arises from the posterior hypopharyngeal wall through Killian's dehiscence and predominantly affects older adults. Surgical and endoscopic treatments may be complicated by adverse events, including recurrent laryngeal nerve injury, cervical emphysema, mediastinitis, and pharyngoesophageal fistula formation. Methods: We report the case of a 69-year-old male who underwent open surgical treatment for Zenker's diverticulum and subsequently developed an upper esophageal fistula complicated by a retroesophageal abscess. Results: The patient was treated using an externally adapted endoluminal vacuum-assisted closure system (EndoVAC), which enabled continuous drainage, local lavage, and progressive closure of the esophageal defect. Conclusions: Endo-VAC therapy represents a safe and minimally invasive therapeutic option for the management of postoperative esophageal fistulas following Zenker's diverticulum surgery and may reduce the need for extensive esophageal reconstruction.
C1 [Ciuntu, Bogdan Mihnea; Ludusanu, Andreea; Zara, Mara Teodora; Corlade-Andrei, Mihaela; Tanevski, Adelina; Stan, Cristinel Ionel; Chiran, Dragos Andrei; Vintila, Dan; Andronic, Dan; Balan, Gheorghe] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Univ St 16, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy
RP Ludusanu, A; Zara, MT (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Univ St 16, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; andreea.ludusanu@umfiasi.ro;
   marazara13@yahoo.com; mihaela.corlade2@umfiasi.ro;
   papancea.adelina@umfiasi.ro; cristinel.stan@umfiasi.ro;
   dragos-andrei.chiran@umfiasi.ro; dan.vintila@umfiasi.ro;
   dan.andronic@umfiasi.ro; gheorghe-g-balan@umfiasi.ro
RI Stan, Cristinel/AAL-5618-2020; Ciuntu, Bogdan/MTF-9477-2025; Tanevski,
   Adelina/LUZ-8095-2024; Corlade-Andrei, Mihaela/HGB-3725-2022; Chiran,
   Dragos Andrei/MTF-7766-2025
OI Ludușanu, Andreea/0009-0003-1785-5785; 
FX This research received no external funding.
CR Abdulsada Mustafa, 2020, VideoGIE, V5, P8, DOI [10.1016/j.vgie.2019.10.004, 10.1016/j.vgie.2019.10.004]
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NR 24
TC 0
Z9 0
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR 7
PY 2026
VL 15
IS 7
AR 2777
DI 10.3390/jcm15072777
EA APR 2026
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GK8JJ
UT WOS:001738782000001
PM 41977077
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rocchi, R
   Hibner-Szaltys, M
   Hallowell, G
   Marcatili, M
AF Rocchi, R.
   Hibner-Szaltys, M.
   Hallowell, G.
   Marcatili, M.
TI Treatment of an abdominal wound with puncture of the left ventral colon
   in a gelding
SO EQUINE VETERINARY EDUCATION
LA English
DT Article; Early Access
DE horse; abdomen; celiotomy; penetrating trauma; peritonitis; wound
ID HORSES; COMPLICATIONS; MANAGEMENT; LAVAGE
AB This report details the treatment of an abdominal wound with puncture of the large intestine and associated complications in an adult horse. The wound was located over the left eleventh costochondral junction. The gelding was referred to the hospital 48 h after the initial injury and presented with pyrexia and dullness. Septic peritonitis was confirmed by abdominocentesis. During exploratory celiotomy, a puncture of the left ventral colon with minimal abdominal contamination was identified. The edges of the penetration site in the left ventral colon were excised, the defect closed in two layers and the abdomen was lavaged. During the post-operative period, the horse showed further signs of septic peritonitis. This was treated with abdominal lavage under standing sedation. Other complications included fever and surgical site infection of the celiotomy incision. The latter was treated with systemic antimicrobials and negative pressure wound therapy. The horse was discharged 12 weeks after surgery and no long-term complications were reported up to 27 months post injury.
C1 [Rocchi, R.; Hibner-Szaltys, M.; Marcatili, M.] Pool House Equine Hosp, Lichfield, England.
   [Hallowell, G.] Med Vet Equine Referrals Ltd, Nottingham, England.
RP Rocchi, R (通讯作者)，Pool House Equine Hosp, Lichfield, England.
EM roberta.rocchi@poolhousevets.co.uk
RI Hallowell, Gayle/A-9965-2018
CR Akasaka H, 2023, JCI INSIGHT, V8, DOI 10.1172/jci.insight.167336
   Askey T, 2023, EQUINE VET EDUC, V35, pE531, DOI 10.1111/eve.13789
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   BAILEY JV, 1983, CAN VET J, V24, P222
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0957-7734
EI 2042-3292
J9 EQUINE VET EDUC
JI Equine Vet. Educ.
PD 2026 APR 13
PY 2026
DI 10.1111/eve.70111
EA APR 2026
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA GL4DH
UT WOS:001739173100001
DA 2026-07-24
ER
PT J
AU Paradiso, FV
   Silvaroli, S
   Nanni, L
AF Paradiso, Filomena Valentina
   Silvaroli, Sara
   Nanni, Lorenzo
TI Negative pressure wound therapy (NPWT) in the open abdomen in a preterm
   newborn with necrotizing enterocolitis: case report
SO ITALIAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Open abdomen; Necrotizing enterocolitis; Negative pressure wound therapy
   (NPWT); Kerlix Antimicrobial Dressing (AMD)
ID VACUUM-ASSISTED CLOSURE
AB Background Necrotizing enterocolitis (NEC) totalis is a devastating intestinal disease that affects similar to 5% of preterm neonates; its appropriate surgical management is still controversial. Although the temporary open abdomen associated with negative pressure wound therapy (NPWT) has become an increasingly used therapeutic option, its use is still relatively limited in premature babies with NEC.
   Case report On the 6th day of life a male preterm neonate born at 32 + 3 weeks of gestational age (1570 g) developed bowel perforation. He underwent a bed-side laparotomy and a NEC totalis was found with three intestinal perforations (one jejunal and two contiguous ileal perforations). In order to re-esplore the baby, an open abdomen NPWT was applied (Suprasorb CNP P3-Lohmann-Rauscher), with an intrabdominal drainage film, setting the pressure at -20 mmHg. After 72 h a second surgery was performed. The entire bowel showed a good trophism; no new perforations were found. The two ileal perforations were closed with running sutures and a jejunostomy was performed. The postoperative course was uneventful and the oral feeding started on the fifth postoperative day. Two months later a barium enema through the mucous fistula showed a normal intestinal progression of the contrast medium, and the jejunostomy was closed.
   Conclusion The temporary open abdomen associated with NPWT is a valuable resource in critical premature neonates; it allows the creation of a "artificial third space" which is crucial in lowering bowel edema and intrabdominal pressure. Moreover, the use of an intrabdominal film may represent a new perspective whose effectiveness needs further studies.
C1 [Paradiso, Filomena Valentina; Silvaroli, Sara; Nanni, Lorenzo] Fdn Policlin Univ Agostino Gemelli IRCCS, Div Pediat Surg, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Paradiso, FV (通讯作者)，Fdn Policlin Univ Agostino Gemelli IRCCS, Div Pediat Surg, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
EM filomenavalentina.paradiso@policlinicogemelli.it;
   sara.silvaroli@policlinicogemelli.it;
   lorenzo.nanni@policlinicogemelli.it
RI ; Paradiso, Filomena/OGN-6517-2025
OI Paradiso, Filomena Valentina/0000-0001-6993-3886; 
CR Fenton SJ, 2007, J PEDIATR SURG, V42, P957, DOI 10.1016/j.jpedsurg.2007.01.029
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   Principles of Best Practice, 2009, VACUUM ASSISTED CLOS
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1720-8424
EI 1824-7288
J9 ITAL J PEDIATR
JI Ital. J. Pediatr.
PD MAR 5
PY 2026
VL 52
IS 1
AR 57
DI 10.1186/s13052-026-02220-x
EA MAR 2026
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA GM2DE
UT WOS:001739717400001
PM 41787431
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU He, ZH
   Yang, HM
AF He, Zhenhua
   Yang, Hongmei
TI Efficacy and safety of negative pressure wound therapy combined with
   alginate dressings for wound management: a meta-analysis
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE alginate; care; dressing; management; negative pressure wound therapy;
   nursing; wound
ID MULTICENTER; CARE
AB <bold>Background: </bold> Wound management remains a clinical challenge, with single-modality therapies such as negative pressure wound therapy (NPWT) or conventional dressings often failing to optimize healing efficiency and quality. This study aimed to systematically evaluate the clinical efficacy of NPWT combined with alginate dressings in wound treatment, providing evidence for clinical decision-making. <bold>Methods: </bold> A comprehensive search was conducted across Chinese and English databases from database inception to 30 November 2025. Randomized controlled trials (RCTs) comparing NPWT combined with alginate dressings (combined group) versus NPWT alone or routine dressing changes (control group) were included. Two researchers independently performed literature screening, data extraction, and risk of bias assessment using the Cochrane RoB 2.0 tool. Meta-analysis was conducted with RevMan 5.4 software. <bold>Results: </bold> A total of 11 RCTs involving 902 participants were included. Pooled results showed that the combined group significantly improved wound healing rate (OR = 2.64, 95% CI 1.60-4.36, I-2 = 30%) and Grade-A healing rate (OR = 4.69, 95% CI 2.56-8.57, I-2 = 0%), shortened healing time (days) (MD = -9.00, 95% CI -9.41 to -8.58, I-2 = 83%), reduced dressing change frequency (MD = -2.54, 95% CI -2.92 to -2.17, I-2 = 77%), and decreased wound pH value (MD = -0.82, 95% CI -1.08 to -0.57, I-2 = 61%) compared with the control group. Heterogeneity was moderate to high for partial outcomes, mainly attributed to variations in NPWT parameters (100-500 mmHg) and dressing protocols. No significant publication bias was detected (all p > 0.05). <bold>Conclusion: </bold> This meta-analysis finds that NPWT combined with alginate dressings significantly improves wound healing outcomes compared to monotherapy, with benefits observed primarily in hospital-based settings. While this combined regimen should be prioritized for complex or chronic wounds, judicious application of parameters-including careful monitoring at higher negative pressures-is warranted, and further health economic evaluation and standardized safety reporting are needed to optimize clinical decision-making.
C1 [He, Zhenhua] Shaoxing Inst Technol, Sch Med & Hlth, Shaoxing, Zhejiang, Peoples R China.
   [Yang, Hongmei] Cent Hosp Enshi Tujia & Miao Autonomous Prefecture, Enshi, Hubei, Peoples R China.
C3 Shaoxing Institute of Technology
RP Yang, HM (通讯作者)，Cent Hosp Enshi Tujia & Miao Autonomous Prefecture, Enshi, Hubei, Peoples R China.
EM wam8f5@sina.com
FU Zhejiang Medical and Health Science and Technology Project [2025KY1706]
FX The author(s) declared that financial support was received for this work
   and/or its publication. This study was funded by Zhejiang Medical and
   Health Science and Technology Project (Grant Number: 2025KY1706).
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NR 39
TC 0
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD APR 1
PY 2026
VL 13
AR 1772888
DI 10.3389/fmed.2026.1772888
EA APR 2026
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GN0WC
UT WOS:001740310700001
PM 41994425
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Figueroa, NS
   Mullen, B
   Rios-Sanchez, M
   Brakke, H
   Martinez-Jorge, J
   Fahradyan, V
AF Figueroa, Nicole Sanchez
   Mullen, Barbara
   Rios-Sanchez, Maria
   Brakke, Holly
   Martinez-Jorge, Jorys
   Fahradyan, Vahe
TI Negative pressure wound therapy vs. standard dressings in penile
   inversion vaginoplasty: Provider perspectives on challenges, benefits,
   and workload
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Penile inversion vaginoplasty; Negative pressure wound therapy; Nursing
   workload; Gender-affirming surgery; Postoperative care; Wound management
AB Penile inversion vaginoplasty (PIV) is the most common genital gender-affirming surgery for transfeminine individuals. Postoperative wound care often involves either traditional bolster dressings or incisional negative pressure wound therapy (iNPWT). While iNPWT has shown potential benefits in wound healing and infection reduction, its impact on nursing workload and practical application in perineal wounds remains underexplored. This study aims to evaluate nursing experiences with iNPWT compared to standard bolster dressings following PIV. A cross-sectional survey was conducted among floor nurses at a single institution with experience managing postoperative PIV patients. The survey assessed challenges encountered with each dressing method, strategies used to address complications, perceived workload, satisfaction, and observations on patient comfort. Descriptive statistics and thematic analysis were used to analyze the data. Sixteen nurses responded (59% response rate), most with >= 3 years of transgender surgical care experience. Overall, 81% reported satisfaction with iNPWT, and 47% perceived it as less burdensome than bolster dressings. Device malfunction, primarily due to air leaks, was the most common issue (81%). However, iNPWT was associated with improved hygiene and reduced need for dressing changes. Nurses employed strategies such as enhanced sealing techniques and increased monitoring to troubleshoot challenges. Despite early technical difficulties, iNPWT was well-received by nursing staff, offering workflow advantages and increased patient comfort. Findings suggest iNPWT is a feasible alternative to bolster dressings in PIV and highlight the importance of nursing support and training for successful implementation. (c) 2025 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Figueroa, Nicole Sanchez; Mullen, Barbara; Rios-Sanchez, Maria; Brakke, Holly; Martinez-Jorge, Jorys; Fahradyan, Vahe] Mayo Clin, Dept Surg, Div Plast Surg, 200 1st St SW, Rochester, MN 55905 USA.
   [Figueroa, Nicole Sanchez] Univ Especialidades Espiritu Santo, Samborondon, Ecuador.
C3 Mayo Clinic; Universidad de Especialidades Espiritu Santo
RP Fahradyan, V (通讯作者)，Mayo Clin, Dept Surg, Div Plast Surg, 200 1st St SW, Rochester, MN 55905 USA.
EM fahradyan.vahe@mayo.edu
RI sanchez, nicole/PGU-4587-2026
OI brakke, holly/0000-0001-5644-7934; Fahradyan, Vahe/0000-0003-4315-7932
CR Hu J, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001726
   Li JS, 2021, INT BRAZ J UROL, V47, P263, DOI [10.1590/S1677-5538.IBJU.2020.0338, 10.1590/s1677-5538.ibju.2020.0338]
   Norman G, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub7
   Przybek-Mita Joanna, 2023, Int J Environ Res Public Health, V20, DOI [10.3390/ijerph20043388, 10.3390/ijerph20043388]
   Sanchez MVR, 2024, PRS-GLOB OPEN, V12, P63, DOI [10.1097/01.gox.0001015472.19190.47, 10.1097/01.Gox.0001015472.19190.47, DOI 10.1097/01.GOX.0001015472.19190.47]
NR 5
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD APR
PY 2026
VL 115
BP 495
EP 498
DI 10.1016/j.bjps.2025.09.019
EA APR 2026
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GN6XM
UT WOS:001740722800001
PM 41219073
DA 2026-07-24
ER
PT J
AU Ahmed, MSA
   Hassan, MIM
   Ibrahim, A
   Lamey, A
   Elsayed, MM
   Elshaboury, A
   Elkasaby, MH
   Abdelrafee, A
AF Ahmed, Mohamed Sherif Ali
   Hassan, Mostafa Ismail Mahmoud
   Ibrahim, Ahmed
   Lamey, Ahmed
   Elsayed, Mahmoud M.
   Elshaboury, Ahmed
   Elkasaby, Mohamed Hamouda
   Abdelrafee, Ahmed
TI Effect of negative pressure wound therapy on surgical wound outcomes in
   colorectal cancer surgery patients: a systematic review and
   meta-analysis
SO BMC SURGERY
LA English
DT Article
DE Negative Pressure Wound Therapy; NPWT; Colorectal Cancer Surgery;
   Surgical Site Infection; and Wound Complications
ID VACUUM-ASSISTED CLOSURE; SITE INFECTIONS; COMPLICATIONS; PREVENTION;
   RESECTION; COLON
AB Background Surgical site infections (SSI) and wound complications are major concerns in colorectal cancer (CRC) surgery. Negative pressure wound therapy (NPWT) has been proposed to reduce these complications, but its efficacy specifically in CRC surgery remains uncertain. This meta-analysis evaluates the impact of NPWT on surgical wound outcomes compared to standard wound care in patients undergoing CRC surgery. Methods A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted up to February 10, 2025, for studies comparing NPWT with standard wound care in CRC surgery patients. The primary outcome was total wound complications. Risk ratios (RR) and mean differences (MD) were pooled using a random-effects model, with heterogeneity assessed using I & sup2; statistics. Results Six studies involving 343 patients (NPWT: 171, control: 172) were included. NPWT did not significantly reduce total wound complications (RR: 0.67, 95% CI: 0.35-1.26, P = 0.21, I & sup2; = 66%). Similarly, no significant differences were found for SSI (RR: 0.80, 95% CI: 0.45-1.43, P = 0.45), even after sensitivity analysis resolved heterogeneity (RR: 0.62, 95% CI: 0.33-1.17, P = 0.14, I & sup2; = 0%). NPWT also showed no significant benefit in preventing wound dehiscence (RR: 2.44, P = 0.35), seroma (RR: 0.87, P = 0.92), or reducing reintervention rates (RR: 0.69, P = 0.36). The length of hospital stay was comparable between groups (MD: -0.25 days, P = 0.80). Conclusion This meta-analysis suggests that NPWT does not significantly reduce wound complications, SSI, or LOS in CRC surgery.
C1 [Ahmed, Mohamed Sherif Ali; Hassan, Mostafa Ismail Mahmoud; Ibrahim, Ahmed; Elshaboury, Ahmed] Mansoura Univ Hosp, Al Mansurah, Egypt.
   [Lamey, Ahmed] Kafr Elsheikh Univ, Fac Med, Dept Gen Surg, Kafr Al Sheikh, Egypt.
   [Elsayed, Mahmoud M.] Med Univ South Carolina, Neurosurg Dept, Charleston, SC USA.
   [Elkasaby, Mohamed Hamouda] Al Azhar Univ, Fac Med, Cairo, Egypt.
   [Abdelrafee, Ahmed] Mansoura Univ, Fac Med, Gastrointestinal Surg Ctr, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Kafrelsheikh University; Medical University of South
   Carolina; Egyptian Knowledge Bank (EKB); Al Azhar University; Egyptian
   Knowledge Bank (EKB); Mansoura University
RP Ahmed, MSA (通讯作者)，Mansoura Univ Hosp, Al Mansurah, Egypt.
EM mohamedsherifaliahmed@gmail.com
RI Lamey, Ahmed/JWA-5019-2024; Ahmed, Mohamed Sherif Ali/MCJ-0437-2025;
   Abdelrafee, Ahmed/S-4009-2018; Hassan, Mostafa Elsayed/ABB-1736-2021
OI Elkasaby, Mohamed Hamouda/0000-0003-1092-7144; 
FU Mansoura University
FX Open access funding provided by The Science, Technology & Innovation
   Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank
   (EKB).
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   Wang SK, 2022, J ORTHOP SURG RES, V17, DOI 10.1186/s13018-022-03070-z
   Wang TK, 2025, J WOUND CARE, V34, P526, DOI 10.12968/jowc.2022.0219
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   Wiatrek Rebecca L, 2008, Clin Colon Rectal Surg, V21, P76, DOI 10.1055/s-2008-1055325
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NR 53
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD APR 11
PY 2026
VL 26
IS 1
AR 278
DI 10.1186/s12893-026-03652-2
EA APR 2026
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GR5EV
UT WOS:001743323900001
PM 41963884
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gruzmark, FS
   Kirsner, RS
   Jaller, JA
AF Gruzmark, Fiona S.
   Kirsner, Robert S.
   Jaller, Jose A.
TI Combining Acellular Dermal Grafts With Negative-Pressure Wound Therapy
   in a Postsurgical Wound: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE acellular dermal graft; extracellular matrix graft; Mohs micrographic
   surgery; negative pressure wound therapy; ulcer; wound
ID MOHS MICROGRAPHIC SURGERY
AB Chronic wounds are expensive and burdensome to the health care system, with some acute wounds, such as wounds after Mohs micrographic surgery (MMS), contributing to this problem. The rate of MMS performed is increasing, and if they become nonhealing, they can be challenging to treat and necessitate proper care. Both acellular dermal grafts and negative-pressure wound therapy are therapies that can be used to treat complicated wounds, but the combination of these 2 therapies has not been extensively studied. The study authors report the successful use of an acellular dermal graft in combination with negative pressure wound therapy in healing a complicated post-MMS wound on the thigh.
C1 [Gruzmark, Fiona S.; Kirsner, Robert S.; Jaller, Jose A.] Univ Miami, Miller Sch Med, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL USA.
   [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Publ Hlth Sci, Miami, FL USA.
   [Gruzmark, Fiona S.; Kirsner, Robert S.] Univ Miami Hosp & Clin Wound Ctr, 1600 NW 10th Ave,Suite 1149, Miami, FL 33136 USA.
   [Gruzmark, Fiona S.; Kirsner, Robert S.] Univ Miami Hosp, 1600 NW 10th Ave,Suite 1149, Miami, FL 33136 USA.
   [Gruzmark, Fiona S.; Kirsner, Robert S.] Univ Miami, Jackson Mem Hosp, Wound Clin, 1600 NW 10th Ave,Suite 1149, Miami, FL 33136 USA.
C3 University of Miami; University of Miami; University System of Ohio;
   Miami University; University of Miami
RP Gruzmark, FS (通讯作者)，Univ Miami Hosp & Clin Wound Ctr, 1600 NW 10th Ave,Suite 1149, Miami, FL 33136 USA.; Gruzmark, FS (通讯作者)，Univ Miami Hosp, 1600 NW 10th Ave,Suite 1149, Miami, FL 33136 USA.; Gruzmark, FS (通讯作者)，Univ Miami, Jackson Mem Hosp, Wound Clin, 1600 NW 10th Ave,Suite 1149, Miami, FL 33136 USA.; Gruzmark, FS (通讯作者)，Univ Miami, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Dept Publ Hlth Sci, Miller Sch Med, 1600 NW 10th Ave,Suite 1149, Miami, FL 33136 USA.
EM fsg28@miami.edu; rkirsner@med.miami.edu; jjaller@med.miami.edu
RI Jaller, Jose/K-2567-2019
CR Alam M, 2013, JAMA DERMATOL, V149, P1378, DOI 10.1001/jamadermatol.2013.6255
   Asgari MM, 2012, DERMATOL CLIN, V30, P167, DOI 10.1016/j.det.2011.08.010
   Bascone CM, 2024, DERMATOL SURG, V50, P814, DOI 10.1097/DSS.0000000000004209
   Chen CY, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-00369-5
   Cho J, 2023, INT WOUND J, V20, P1053, DOI 10.1111/iwj.13958
   Hays TR., 2022, PLAST RECONSTR SURG, V150, p655e670e
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   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
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   Sen CK, 2021, ADV WOUND CARE, V10, P281, DOI 10.1089/wound.2021.0026
   Shi L, 2013, INT J BURNS TRAUMA, V3, P173
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   Vecin NM, 2023, FRONT MED-LAUSANNE, V10, DOI 10.3389/fmed.2023.1154567
   Wu Stephanie, 2023, J Wound Care, V32, pS1, DOI [10.12968/jowc.2023.32.sup4b.s1, 10.12968/jowc.2023.32.Sup4b.S1]
   Wu ZY, 2024, BIOMED MATER, V19, DOI 10.1088/1748-605X/ad80ed
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   Zhang LP, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/8824737
NR 21
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAY
PY 2026
VL 39
IS 4
BP E194
EP E196
DI 10.1097/ASW.0000000000000435
PG 3
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA GS6PH
UT WOS:001744100500014
PM 41920930
DA 2026-07-24
ER
PT J
AU Yuan, L
   Sun, YY
   Yan, JJ
AF Yuan, Ling
   Sun, Yingying
   Yan, Jianjun
TI Case Report: A case of Fournier's gangrene of the scrotum
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE Fournier's gangrene; necrotizing fasciitis; soft tissue infection;
   vacuum sealing drainage; wound managemen
AB A 68-year-old man with poorly controlled type 2 diabetes and untreated stage 2 hypertension presented with a 7-day history of painful scrotal and perianal swelling. Imaging revealed subcutaneous gas and necrotic sinus tracts, and tissue cultures showed a polymicrobial infection. Fournier's gangrene was diagnosed. Prompt surgical debridement, vacuum sealing drainage (VSD), glycemic control, and antibiotic therapy led to complete recovery, highlighting the importance of early recognition and aggressive management.
C1 [Yuan, Ling; Sun, Yingying; Yan, Jianjun] Shandong First Med Univ, Shandong Prov Hosp, Dept Dermatol, Jinan, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical Sciences
RP Yan, JJ (通讯作者)，Shandong First Med Univ, Shandong Prov Hosp, Dept Dermatol, Jinan, Shandong, Peoples R China.
EM jianjun19870103@163.com
CR Chokshi A, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.44383
   Czymek R, 2013, COLORECTAL DIS, V15, P1529, DOI 10.1111/codi.12396
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   Hagedorn JC, 2017, NAT REV UROL, V14, P205, DOI 10.1038/nrurol.2016.243
   Kopechek KJ, 2025, CURR UROL REP, V26, DOI 10.1007/s11934-025-01275-3
   Leiblein M, 2020, ORTHOP SURG, V12, P1733, DOI 10.1111/os.12804
   Mao TC, 2022, BMC UROL, V22, DOI 10.1186/s12894-022-00975-z
   Nayyar C, 2025, ARCH MED HEALTH SCI, DOI [10.4103/amhs.amhs_219_24, 10.4103/amhs.amhs_219_24, DOI 10.4103/AMHS.AMHS_219_24]
   Tuncel A, 2006, EUR UROL, V50, P838, DOI 10.1016/j.eururo.2006.01.030
NR 9
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD APR 8
PY 2026
VL 13
AR 1791234
DI 10.3389/fmed.2026.1791234
EA APR 2026
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GU3RV
UT WOS:001745260500001
PM 42027829
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhao, ZK
   Cao, L
   Xu, SJ
   Yang, F
   Gao, S
   Ren, CX
   Xu, XC
   Li, XQ
AF Zhao, Zhikun
   Cao, Lei
   Xu, Shengju
   Yang, Fan
   Gao, Shang
   Ren, Chuanxin
   Xu, Xingchao
   Li, Xiangqi
TI Case Report: Giant undifferentiated pleomorphic sarcoma of the breast
   combined with contralateral high-grade intraductal carcinoma
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE breast cancer; case report; high-grade intraductal carcinoma;
   multidisciplinary treatment; undifferentiated pleomorphic sarcoma
ID AMERICAN JOINT COMMITTEE; SOFT-TISSUE SARCOMA; CANCER; TUMORS;
   CLASSIFICATION; STAGE
AB This article reports an exceptionally rare case of a 43-year-old female presenting with concurrent giant pleomorphic undifferentiated sarcoma and high-grade intraductal carcinoma of the contralateral breast. The tumor, remarkably large and comparable in size to a basketball, presented significant diagnostic and therapeutic challenges. Following a multidisciplinary consultation, the patient underwent a comprehensive treatment regimen, which included left mastectomy, modified radical mastectomy, vacuum-assisted closure (VSD) negative pressure drainage, radiotherapy, and endocrine therapy for the high-grade intraductal carcinoma. Post-treatment follow-up over a period of 2 to 5 years revealed a satisfactory recovery with no evidence of recurrence or metastasis. This case underscores the critical role of a multidisciplinary approach in managing rare and complex breast malignancies and highlights the potential for favorable outcomes even in cases involving exceptionally large tumors.
C1 [Zhao, Zhikun] Shandong First Med Univ, Affiliated Hosp 2, Dept Gen Surg, Tai An, Shandong, Peoples R China.
   [Cao, Lei] Qingdao Univ, Affiliated Taian City Cent Hosp, Dept Breast Surg, Tai An, Shandong, Peoples R China.
   [Xu, Shengju] Shandong First Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Tai An, Shandong, Peoples R China.
   [Yang, Fan] Shandong First Med Univ, Affiliated Hosp 2, Dept Pathol, Tai An, Shandong, Peoples R China.
   [Gao, Shang; Ren, Chuanxin; Xu, Xingchao; Li, Xiangqi] Shandong First Med Univ, Affiliated Hosp 2, Dept Breast Surg, Tai An, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Qingdao University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong First Medical University
   & Shandong Academy of Medical Sciences; Shandong First Medical
   University & Shandong Academy of Medical Sciences
RP Xu, XC; Li, XQ (通讯作者)，Shandong First Med Univ, Affiliated Hosp 2, Dept Breast Surg, Tai An, Shandong, Peoples R China.
EM xuxingchao1@163.com; drlixqi@hotmail.com
FU National Natural Science Foundation of China [82274538]; Natural Science
   Foundation of Shandong Province [ZR2020MH357]; Shandong Province Medical
   and Health Technology Development Project [2019WS406]; Shandong Medical
   Association Clinical Research Fund - Qilu Special Project
   [YXH2022ZX02161]; Shandong Province "Traditional Chinese Medicine Plus"
   New Product R&D and Promotion Project
FX The author(s) declared that financial support was received for this work
   and/or its publication. The National Natural Science Foundation of China
   (grant no. 82274538), The Natural Science Foundation of Shandong
   Province (grant no. ZR2020MH357), and Shandong Province Medical and
   Health Technology Development Project (grant no. 2019WS406), Shandong
   Medical Association Clinical Research Fund - Qilu Special Project (grant
   no. YXH2022ZX02161), Shandong Province "Traditional Chinese Medicine
   Plus" New Product R&D and Promotion Project.
CR Anzali BC, 2023, INT J SURG CASE REP, V107, DOI 10.1016/j.ijscr.2023.108307
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NR 21
TC 0
Z9 0
U1 4
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD APR 10
PY 2026
VL 16
AR 1633750
DI 10.3389/fonc.2026.1633750
EA APR 2026
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GW8OZ
UT WOS:001746952600001
PM 42038374
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kondor, AE
   Baracs, J
   Varga, P
   Gowda, YS
   Garcia, E
   Halvax, P
   Vereczkei, A
AF Kondor, Ariella Edina
   Baracs, Jozsef
   Varga, Peter
   Gowda, Yashwanth Sudhendra
   Garcia, Elisabeth
   Halvax, Peter
   Vereczkei, Andras
TI Negative Pressure Wound Therapy for Complex Perianal Fistulas: A Case
   Series
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE colorectal surgery; negative pressure wound therapy; perianal fistula;
   wound healing
AB Complex perianal fistulas are difficult to treat because of high recurrence rates and the need to preserve sphincter function. Negative pressure wound therapy (NPWT) improves healing in complex wounds, but its role in perianal fistula surgery is not well defined. This case series evaluated the feasibility, safety and early clinical outcomes of NPWT following surgical excision of complex perianal fistula tracts. A retrospective case series was conducted including eight adults with high or otherwise complex cryptoglandular perianal fistulas treated by surgical debridement followed by portable NPWT. Outcomes assessed were time to epithelialisation, symptom resolution, recurrence, complications and NPWT-related technical issues and refinements. Seven of eight patients achieved complete epithelialisation of the perianal wound after NPWT. One patient developed recurrence and required ongoing seton drainage. Over the course of the series, optimisation of sealing, sponge contouring and use of a bridge technique improved dressing reliability and wound progression. No NPWT device-related adverse events were observed. NPWT appears to be a feasible, well tolerated adjunct to surgery for complex cryptoglandular perianal fistulas, with high early healing rates and no device complications in this small series. Larger prospective studies are warranted to confirm efficacy and define optimal technical parameters.
C1 [Kondor, Ariella Edina; Baracs, Jozsef; Varga, Peter; Gowda, Yashwanth Sudhendra; Garcia, Elisabeth; Halvax, Peter; Vereczkei, Andras] Univ Pecs, Med Sch, Dept Surg, Pecs, Hungary.
C3 University of Pecs
RP Kondor, AE (通讯作者)，Univ Pecs, Med Sch, Dept Surg, Pecs, Hungary.
EM kondor.ariella@pte.hu
RI Vereczkei, Andras/AAI-7089-2020
CR Abbas MA, 2008, AM SURGEON, V74, P921
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR 26
PY 2026
VL 23
IS 5
AR e70920
DI 10.1111/iwj.70920
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GZ0BM
UT WOS:001748409100001
PM 42036402
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kim, JH
   Kim, JW
   Ha, M
   Lee, KM
AF Kim, Jong-Ho
   Kim, Jin-Woo
   Ha, Minju
   Lee, Kyoung Min
TI Retrospective analysis of healing outcomes and associated factors in
   patients with pressure ulcers
SO MEDICINE
LA English
DT Article
DE logistic regression; negative pressure wound therapy; pressure-ulcer;
   prognostic factors; retrospective study; wound healing
ID SPINAL-CORD-INJURY; RISK-FACTORS; WOUND THERAPY; PREDICTORS
AB Pressure ulcers (PUs) are serious complications among immobilized or chronically ill patients, often resulting in prolonged hospitalization, morbidity, and increased healthcare costs. Despite therapeutic advances, predictors of long-term healing remain unclear. This study aimed to identify factors associated with 1-year healing outcomes in patients with advanced PUs. This retrospective cohort study included adult patients diagnosed with PUs of grade 2 or higher between January 2020 and January 2025. Clinical, laboratory, and wound-related variables were obtained from electronic records, including demographic data, comorbidities, nutritional indicators, ulcer features (stage, location, size, infection, and bone exposure), and treatment modalities such as negative pressure wound therapy (NPWT) and surgical debridement. The primary outcome measure was complete wound healing within 12 months. Univariate and multivariate logistic regression analyses identified independent predictors of healing. A total of 240 patients (mean age, 61.5 +/- 10.6 years; 69.6% male) were included in the final analysis. Complete healing at 12 months was achieved in 48.8% of the patients. In the multivariate logistic regression model, NPWT, hospital-based treatment, lower initial ulcer stage, and absence of paralysis were independently associated with complete healing, with all predictors reaching statistical significance (all P < .01). NPWT, hospital-based management, lower initial ulcer stage, and absence of paralysis were strongly associated with improved 1-year healing outcomes in patients with advanced PUs. These findings highlight the importance of early, structured wound care and suggest that both the treatment setting and patient mobility status play critical roles in long-term recovery.
C1 [Kim, Jong-Ho; Kim, Jin-Woo; Ha, Minju] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Plast & Reconstruct Surg, Seongnam, South Korea.
   [Lee, Kyoung Min] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Orthoped Surg, 82 Gumi Ro 173beon Gil, Seongnam 463707, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Lee, KM (通讯作者)，Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Orthoped Surg, 82 Gumi Ro 173beon Gil, Seongnam 463707, South Korea.
EM jinwooo_kim@naver.com; jinwooo_kim@naver.com; mjha0303@naver.com;
   oasis100@empal.com
FU Institute for Information and Communications Technology Promotion
   [2022-0-00682]
FX This work was supported by an Institute of Information and
   Communications Technology Planning and Evaluation (IITP) grant funded by
   the Korean government(MSIT; No. 2022-0-00682, Development of XR twin
   technology for the management of chronic skin diseases in the elderly).
CR Alabdulhadi Abdulhadi A, 2024, Cureus, V16, pe73199, DOI [10.7759/cureus.73199, 10.7759/cureus.73199]
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NR 31
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR 24
PY 2026
VL 105
IS 17
AR e48386
DI 10.1097/MD.0000000000048386
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HB7RQ
UT WOS:001750280400033
PM 42071811
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Jiang, YY
   Ni, JD
   Zhang, L
   Jiang, LJ
   Li, X
AF Jiang, Yangyang
   Ni, Jindi
   Zhang, Lu
   Jiang, Lijing
   Li, Xiang
TI Refractory abdominal compartment syndrome secondary to ruptured
   abdominal aortic aneurysm treated with total colectomy and upper rectal
   resection: A case report and literature review
SO MEDICINE
LA English
DT Article
DE abdominal compartment syndrome; multiple organ dysfunction syndrome;
   ruptured abdominal aortic aneurysm
ID RISK-FACTORS; REPAIR; DIAGNOSIS
AB Rationale:Ruptured abdominal aortic aneurysm (RAAA) is a critical condition often complicated by multiple organ dysfunction syndrome (MODS), which can significantly impede recovery following surgical intervention. Abdominal compartment syndrome (ACS) is a widely recognized but highly lethal postoperative complication.Patient concerns:A 69-year-old male presented with acute abdominal pain and hemorrhagic shock.Diagnoses:RAAA with active extravasation was confirmed, and following surgical repair, the patient developed MODS, including hepatorenal failure and acute respiratory distress syndrome. Twenty-one days postoperatively, secondary ACS led to colonic ischemia.Interventions:The patient was managed using staged surgical interventions, including decompressive laparotomy, negative pressure wound therapy systems, and definitive total colectomy with upper rectal resection due to refractory ACS characterized by transmural colonic necrosis.Outcomes:The patient showed significant recovery and was discharged after 81 days of hospitalization. At 1-month follow-up, he reported normal oral intake and no recurrence of major complications.Lessons:This case illustrates the effectiveness of a phased damage control strategy in managing high-risk RAAA patients, demonstrating that early prediction, timely intervention, and multidisciplinary care can significantly improve survival outcomes.
C1 [Jiang, Yangyang; Ni, Jindi; Zhang, Lu; Jiang, Lijing; Li, Xiang] Fudan Univ, Minhang Hosp, Dept Crit Care Med, 39 Xinling Rd, Shanghai 201199, Peoples R China.
C3 Fudan University
RP Li, X (通讯作者)，Fudan Univ, Minhang Hosp, Dept Crit Care Med, 39 Xinling Rd, Shanghai 201199, Peoples R China.
EM jyy009009@126.com; nijindi_mh@fudan.edu.cn; 18231360063@fudan.edu.cn;
   lijing_jiang@fudan.edu.cn; xiangli_mh@fudan.edu.cn
CR Ambler GK, 2015, EUR J VASC ENDOVASC, V50, P443, DOI 10.1016/j.ejvs.2015.06.024
   DuBose JJ, 2015, J TRAUMA ACUTE CARE, V78, P215, DOI 10.1097/TA.0000000000000520
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR 24
PY 2026
VL 105
IS 17
AR e48285
DI 10.1097/MD.0000000000048285
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HB7XN
UT WOS:001750295700013
PM 42071870
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Ciuntu, BM
   Viciriuc, EE
   Ludusanu, A
   Tanevski, A
   Corlade-Andrei, M
   Peiu, SN
   Dragomir, RA
   Vintila, D
   Stan, CI
   Balan, G
AF Ciuntu, Bogdan Mihnea
   Viciriuc, Edwina-Elena
   Ludusanu, Andreea
   Tanevski, Adelina
   Corlade-Andrei, Mihaela
   Peiu, Sorin Nicolae
   Dragomir, Raluca Alina
   Vintila, Dan
   Stan, Cristinel Ionel
   Balan, Gheorghe
TI Upper Esophageal Perforation with Cervico-Mediastinal Extension
   Successfully Treated with Endoluminal Vacuum Therapy: A Case Report
   Highlighting Inflammatory Marker Dynamics
SO LIFE-BASEL
LA English
DT Article
DE cervicomediastinitis; cervico-mediastinal abscess; cervical esophagus;
   cervical esophageal perforation; EVAC; deep neck infection; tracheostomy
ID COMPLICATION; MANAGEMENT; DEFECTS
AB Background: Upper esophageal perforations are life-threatening conditions associated with a high risk of mediastinitis, sepsis, and multiorgan failure. Standard management often requires extensive surgical intervention, which carries substantial morbidity. Methods: We report the case of a 56-year-old male with an iatrogenic cervical esophageal perforation complicated by cervicomediastinal abscess formation. Due to anatomical constraints preventing standard endoluminal approaches, a hybrid organ-preserving strategy was employed, consisting of surgical drainage combined with an externally adapted vacuum-assisted closure (VAC) system applied adjacent to the esophageal defect. Results: The patient demonstrated progressive clinical improvement without the need for esophageal diversion or major reconstructive surgery. Inflammatory markers were monitored serially and showed a downward trend, serving as adjunctive indicators of treatment response. The esophageal defect healed successfully, was confirmed radiologically, and no treatment-related complications were observed. Conclusions: This case suggests that externally adapted VAC therapy may represent a potential organ-preserving option in selected patients with complex cervical esophageal perforations when conventional techniques are not feasible. Further studies are required to validate this approach.
C1 [Ciuntu, Bogdan Mihnea; Tanevski, Adelina; Vintila, Dan] Grigore T Popa Univ Med & Pharm Iasi, Dept Gen Surg, Iasi 700115, Romania.
   [Viciriuc, Edwina-Elena; Dragomir, Raluca Alina] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Iasi 700115, Romania.
   [Ludusanu, Andreea; Stan, Cristinel Ionel] Grigore T Popa Univ Med & Pharm Iasi, Dept Morphofunct Sci Anat 1, Iasi 700115, Romania.
   [Corlade-Andrei, Mihaela] Grigore T Popa Univ Med & Pharm Iasi, Dept Emergency Med, Surg 2, Iasi 700115, Romania.
   [Peiu, Sorin Nicolae] Grigore T Popa Univ Med & Pharm Iasi, Dept Vasc Surg, Iasi 700115, Romania.
   [Balan, Gheorghe] Grigore T Popa Univ Med & Pharm Iasi, Dept Gastroenterol, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy; Grigore T Popa University of
   Medicine & Pharmacy
RP Viciriuc, EE (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Iasi 700115, Romania.; Ludusanu, A (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Dept Morphofunct Sci Anat 1, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; edwinaviciriuc@yahoo.com;
   andreea.ludusanu@umfiasi.ro; papancea.adelina@umfiasi.ro;
   mihaela.corlade2@umfiasi.ro; sorin-nicolae.peiu@umfiasi.ro;
   raluca.dragomir@umfiasi.ro; dan.vintila@umfiasi.ro;
   cristinel.stan@umfiasi.ro; gheorghe-g-balan@umfiasi.ro
RI Stan, Cristinel/AAL-5618-2020; Ciuntu, Bogdan/MTF-9477-2025; Dragomir,
   Raluca Alina/AAV-7080-2020; Tanevski, Adelina/LUZ-8095-2024;
   Corlade-Andrei, Mihaela/HGB-3725-2022
OI Ludușanu, Andreea/0009-0003-1785-5785
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NR 23
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD APR 10
PY 2026
VL 16
IS 4
AR 639
DI 10.3390/life16040639
EA APR 2026
PG 11
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA HC3MB
UT WOS:001750671500001
PM 42073449
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Küçük, E
   Akilli, AF
   Ordulu, R
   Sengül, M
   Kayhan, ME
   Akdeniz, E
   Ulubay, M
   Atilla, MK
AF Kucuk, Emrah
   Akilli, Ahmet Furkan
   Ordulu, Reha
   Sengul, Mesut
   Kayhan, Muhammed Esad
   Akdeniz, Ekrem
   Ulubay, Mahmut
   Atilla, Mustafa Kemal
TI Outcomes of vacuum-assisted closure therapy (VAC) in patients with
   Fournier's gangrene: a retrospective cohort study
SO IRISH JOURNAL OF MEDICAL SCIENCE
LA English
DT Article; Early Access
DE Debridement; Fournier's gangrene; Vacuum-assisted closure
ID PRESSURE WOUND THERAPY; SKIN-GRAFT
AB Objective To evaluate the association between vacuum-assisted closure therapy and clinical outcomes, particularly mortality, in patients surgically treated for Fournier's gangrene. Methods This retrospective cohort study included 268 patients treated for Fournier's gangrene between 2015 and 2025. Patients were divided into two groups: debridement alone (Group 1, n = 160) and debridement plus vacuum-assisted closure therapy (Group 2, n = 108). Demographic characteristics, comorbidities, laboratory findings, Fournier Gangrene Severity Index, intensive care unit admission, additional surgical procedures, length of stay, and mortality were compared. Multivariate logistic regression was performed to identify independent predictors of mortality. Results Observed mortality was lower in the vacuum-assisted closure therapy group than in the debridement-only group (7.4% vs. 16.9%, p = 0.038). However, multivariate analysis demonstrated that only intensive care unit admission (OR 6.40, 95% CI 1.52-26.89, p = 0.011) and Fournier Gangrene Severity Index score (OR 5.57, 95% CI 2.91-10.71, p < 0.001) were independently associated with mortality. Vacuum-assisted closure therapy was not an independent predictor (OR 0.58, 95% CI 0.16-2.10, p = 0.409). The vacuum-assisted closure therapy group underwent more debridement procedures and had a longer hospital stay. Conclusion Although vacuum-assisted closure therapy was associated with lower unadjusted mortality, survival was primarily determined by disease severity and intensive care unit admission. Vacuum-assisted closure therapy may improve wound management; however, its impact on survival appears influenced by baseline clinical status. Prospective studies are needed to clarify its role in Fournier's gangrene management.
C1 [Kucuk, Emrah; Akilli, Ahmet Furkan; Akdeniz, Ekrem; Ulubay, Mahmut; Atilla, Mustafa Kemal] Samsun Univ, Fac Med, Dept Urol, Samsun, Turkiye.
   [Ordulu, Reha; Sengul, Mesut; Kayhan, Muhammed Esad] Samsun City Hosp, Urol Clin, Samsun, Turkiye.
C3 Samsun University
RP Küçük, E (通讯作者)，Samsun Univ, Fac Med, Dept Urol, Samsun, Turkiye.
EM emrah.kucuk@samsun.edu.tr
RI Atilla, Mustafa/NEU-6329-2025
FU Samsun University
FX Open access funding provided by the Scientific and Technological
   Research Council of Turkiye (TUB & Idot;TAK).
CR Altomare M, 2022, J PERS MED, V12, DOI 10.3390/jpm12101695
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0021-1265
EI 1863-4362
J9 IRISH J MED SCI
JI Irish J. Med. Sci.
PD 2026 APR 27
PY 2026
DI 10.1007/s11845-026-04416-w
EA APR 2026
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HE2AZ
UT WOS:001751930500001
PM 42043476
OA hybrid
DA 2026-07-24
ER
PT J
AU Clark, A
   Abdallah, C
   Ash, M
   Knaus, W
   Brown, C
   Ghareeb, P
AF Clark, Alexa
   Abdallah, Calvin
   Ash, Makenna
   Knaus, William
   Brown, Ciara
   Ghareeb, Paul
TI Re-Evaluation of the Ideal Injury to Flap Time Frame for Lower Extremity
   Free Flap Reconstruction: Is 72 h Still the Gold Standard?
SO MICROSURGERY
LA English
DT Article
ID MICROSURGICAL RECONSTRUCTION; TRAUMA; COVERAGE; COMPLICATIONS;
   FRACTURES; OUTCOMES; UPDATE; FATE
AB Background Traumatic lower extremity injuries often require free tissue transfer (FTT) for limb salvage when local tissue is insufficient. Traditionally, reconstruction within 72 h has been considered optimal; however, advancements in wound management and perioperative care have challenged this paradigm.<br /> Objective To evaluate outcomes of lower extremity FTT based on time from injury to reconstruction.<br /> Methods A retrospective review was performed on patients undergoing lower extremity FTT after trauma at a single Level 1 trauma center (2014-2022). Patients were grouped by time from injury to flap: (< 3 days, 4-21 days, 22-90 days, and > 90 days). Ninety nine percent of patients were managed with negative-pressure wound therapy (NPWT) prior to definitive reconstruction. Outcomes included flap loss, complications, infection, osteomyelitis, nonunion, and amputation. Associations with comorbidities, surgical techniques, and fracture characteristics were assessed.<br /> Results Among 102 patients, timing of reconstruction showed no significant differences in flap loss (p = 0.56), complications (p = 0.42), nonunion (p = 0.54), osteomyelitis (p = 0.19), or amputation (p = 0.58). No independent predictors of flap loss or complications were identified. Nonunion was associated with middle/proximal fracture levels (p = 0.0092), Masquelet technique (p = 0.0004), and higher Modified Frailty Index (p = 0.05). Osteomyelitis correlated with male gender (p = 0.01), proximal fracture level (p = 0.0098), and Masquelet technique (p = 0.0095). Amputation was associated with latissimus and radial forearm flaps (p = 0.0081), ipsilateral femur fracture (p = 0.0063), hypertension (p = 0.011), and higher ASA score (p = 0.0021).<br /> Conclusion In this series, delayed FTT beyond 72 h was not associated with increased flap loss or limb-threatening complications. Delayed reconstruction may optimize patient and wound factors, though aggressive wound management is essential. Given the retrospective design, uneven group sizes, and small early reconstruction cohort, these findings should be interpreted cautiously. Further research with larger cohorts and long-term outcomes is warranted.
C1 [Clark, Alexa; Abdallah, Calvin; Ash, Makenna] Emory Univ, Sch Med, Atlanta, GA USA.
   [Knaus, William; Ghareeb, Paul] Emory Univ, Div Plast & Reconstruct Surg, Atlanta, GA 30322 USA.
   [Brown, Ciara] MD Anderson Canc Ctr, Dept Plast & Reconstruct Surg, Houston, TX USA.
C3 Emory University; Emory University; University of Texas System; UTMD
   Anderson Cancer Center
RP Ghareeb, P (通讯作者)，Emory Univ, Div Plast & Reconstruct Surg, Atlanta, GA 30322 USA.
EM paul.ghareeb@emory.edu
RI Ghareeb, Paul/ABA-7780-2022
CR Ahmed H, 2025, ANN ROY COLL SURG, V107, P383, DOI [10.1308/rcsann.2023.0022, 10.1308/rcsann.2023.0022]
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NR 28
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD APR 28
PY 2026
VL 46
IS 4
AR e70228
DI 10.1002/micr.70228
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HE5QS
UT WOS:001752174900001
PM 42047372
DA 2026-07-24
ER
PT J
AU Pirski, MI
   Malerba, S
   Marano, L
   Kur, M
   Skokowski, J
   Swierblewski, M
AF Pirski, Maria Ignacy
   Malerba, Silvia
   Marano, Luigi
   Kur, Martyna
   Skokowski, Jaroslaw
   Swierblewski, Maciej
TI Negative Pressure Wound Therapy as a Key Strategy in the Management of
   Severe Diabetic Foot Ulcers in Septic Frail Patients: A Case Series
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE amputation; complicated diabetic foot; frail septic patients; NPWT;
   wound healing
ID UPDATE; RISK
AB Diabetes mellitus represents a major global health challenge, with over 537 million adults currently affected worldwide. Among its complications, diabetic foot ulcers remain a leading cause of morbidity, hospitalization and amputation, imposing a significant socioeconomic burden. Effective management requires a multidisciplinary approach integrating surgical, medical and rehabilitative expertise. Negative pressure wound therapy has demonstrated clinical efficacy in promoting granulation tissue formation, accelerating wound healing, and reducing infection rates compared with conventional dressings. This case series presents the management of four frail, septic patients with severe diabetic foot ulcers treated between 2023 and 2025 in an academic surgical department. All patients required surgical intervention, including debridement or partial amputation, combined with negative pressure wound therapy and, in selected cases, revascularization or skin grafting. One case utilized an electrospun nanofiber dressing which enhanced wound granulation and shortened healing time. Outcomes varied according to systemic comorbidities, vascular status and glycemic control; however, NPWT consistently supported wound stabilization and preparation for definitive closure. These findings reinforce the essential role of interdisciplinary collaboration and advanced wound technologies in the treatment of complex diabetic foot infections, particularly in frail or septic patients, and highlight the potential of nanofiber-based dressings as adjunctive therapies in comprehensive diabetic foot care.
C1 [Pirski, Maria Ignacy; Malerba, Silvia; Marano, Luigi; Kur, Martyna; Skokowski, Jaroslaw; Swierblewski, Maciej] St Wojciech Hosp, Nicolaus Copernicus Hlth Ctr, Dept Gen Surg & Surg Oncol, Gdansk, Poland.
   [Malerba, Silvia; Marano, Luigi; Skokowski, Jaroslaw] Acad Appl Med & Social Sci, Dept Med, AMiSNS Akad Medycznych I Spolecznych Nauk Stosowan, Elblag, Poland.
   [Malerba, Silvia] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Bari, Italy.
   [Marano, Luigi] Dnipro State Med Univ, Dept Surg, Dnipro, Ukraine.
C3 Universita degli Studi di Bari Aldo Moro; Dnipro State Medical
   University
RP Marano, L (通讯作者)，St Wojciech Hosp, Nicolaus Copernicus Hlth Ctr, Dept Gen Surg & Surg Oncol, Gdansk, Poland.; Marano, L (通讯作者)，Acad Appl Med & Social Sci, Dept Med, AMiSNS Akad Medycznych I Spolecznych Nauk Stosowan, Elblag, Poland.; Marano, L (通讯作者)，Dnipro State Med Univ, Dept Surg, Dnipro, Ukraine.
EM l.marano@amisns.edu.pl
RI Marano, Luigi/K-4944-2013; Skokowski, Jaroslaw/C-6906-2011
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR 28
PY 2026
VL 23
IS 5
AR e70926
DI 10.1111/iwj.70926
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA HE5UY
UT WOS:001752186000001
PM 42049636
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhou, JQ
   Yu, JJ
   Hu, TS
   Li, JY
   Ding, CC
   Chen, LH
   Wu, H
   Zhang, M
AF Zhou, Jiaqi
   Yu, Jingjing
   Hu, Tianshuo
   Li, Jingyi
   Ding, Cuicui
   Chen, Lihui
   Wu, Hui
   Zhang, Min
TI Functionalized collagen-based sponge dressing integrating negative
   pressure wound therapy and photothermal antibacterial treatment for
   advanced wound management
SO BIOMATERIALS SCIENCE
LA English
DT Article
ID POLYVINYL-ALCOHOL FOAM; HYDROGELS; MEMBRANE; UV
AB Negative pressure wound therapy (NPWT) has proven effective in promoting wound healing. However, developing an NPWT sponge dressing that integrates good biocompatibility, mechanical stability under physiological conditions, and robust antibacterial properties remains challenging. In this study, a multifunctional graphene oxide/polyvinyl alcohol/collagen (GO/PVA/COL) composite sponge was prepared through a low-temperature foaming process. The introduction of GO significantly improved the mechanical properties of the composite sponge (maximum compressive stress = 20.2 kPa). Cyclic and long-term compression tests confirmed its excellent structural recovery in the wet state (permanent deformation rate 1.33% upon 0.05% GO). In aquatic environments, the composite sponge maintained stable performance under negative pressure suction up to 24 kPa, demonstrating high drainage efficiency. Moreover, GO endowed the composite sponge with a unique photothermal effect, enabling it to achieve inhibition rates exceeding 96% against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) under NIR irradiation. With the help of the photothermal effect, the composite sponge can effectively promote the repair of ulcerative wounds caused by infection. Additionally, the composite sponge displayed favorable in vitro biodegradability and cell compatibility. These findings highlight the potential of the GO/PVA/COL composite sponge as a novel NPWT dressing and provide a promising strategy for developing high-performance multifunctional wound therapy materials.
C1 [Zhou, Jiaqi; Hu, Tianshuo; Chen, Lihui; Wu, Hui; Zhang, Min] Fujian Agr & Forestry Univ, Coll Mat Engn, Fuzhou 350002, Peoples R China.
   [Yu, Jingjing; Ding, Cuicui] Fujian Univ Technol, Sch Urban & Environm Engn, Fuzhou 350118, Peoples R China.
   [Li, Jingyi] Fujian Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Fuzhou 350122, Peoples R China.
   [Chen, Lihui; Zhang, Min] Natl Forestry & Grassland Adm, Key Lab Plant Fiber Funct Mat, Fuzhou 350108, Peoples R China.
C3 Fujian Agriculture & Forestry University; Fujian University of
   Technology; Fujian Medical University
RP Zhang, M (通讯作者)，Fujian Agr & Forestry Univ, Coll Mat Engn, Fuzhou 350002, Peoples R China.; Ding, CC (通讯作者)，Fujian Univ Technol, Sch Urban & Environm Engn, Fuzhou 350118, Peoples R China.; Zhang, M (通讯作者)，Natl Forestry & Grassland Adm, Key Lab Plant Fiber Funct Mat, Fuzhou 350108, Peoples R China.
EM dingcuicui.1124@163.com; mzhang@fafu.edu.cn
RI Chen, lihui/IXD-5425-2023; Ding, Cuicui/QIR-5181-2026
OI Chen, Li Hui/0009-0002-9978-9509
FU National Natural Science Foundation of China [22178056, 22078060]
FX This work was financially supported by the National Natural Science
   Foundation of China (Grant No. 22178056 & 22078060), Outstanding Youth
   Natural Science Foundation of Fujian Province (Grant No. 2024J09047),
   Fuzhou Science and Technology Major Project (2023-ZD-008).
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   Yin YC, 2018, INT J SURG, V50, P43, DOI 10.1016/j.ijsu.2017.12.020
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NR 48
TC 0
Z9 0
U1 0
U2 0
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2047-4830
EI 2047-4849
J9 BIOMATER SCI-UK
JI Biomater. Sci.
PD JUN 2
PY 2026
VL 14
IS 11
BP 2943
EP 2955
DI 10.1039/d6bm00297h
EA APR 2026
PG 13
WC Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA IV4GO
UT WOS:001752533200001
PM 42052720
DA 2026-07-24
ER
PT J
AU Öner, S
   Bekyürek, U
   Öner, BA
   Üre, I
   Yenilmez, A
AF Oner, Suleyman
   Bekyurek, Utku
   Oner, Betul Altintas
   Ure, Iyimser
   Yenilmez, Aydin
TI Evaluation of the Role of VAC in the Treatment of Fournier's Gangrene
SO ANZ JOURNAL OF SURGERY
LA English
DT Article; Early Access
DE andrology; Fournier's gangrene; infectious disease; surgical
   debridement; VAC
ID ASSISTED CLOSURE; MANAGEMENT; THERAPY
AB Objective: Standard treatment for Fournier's gangrene (FG) includes hemodynamic stabilization, aggressive surgical debridement, and broad-spectrum antibiotics. However, prolonged hospitalizations and multiple debridements increase costs and reduce productivity. This study compares vacuum-assisted closure (VAC) therapy with open wound dressing (OWD) in post-debridement management of FG. Materials and methods: Data of 60 patients diagnosed with FG and treated in our clinic were retrospectively analyzed. Data collected included demographic characteristics, comorbid systemic diseases, presence of sepsis at initial presentation, the origin of the gangrene (urogenital or perianal), FGSI, the need for additional surgical interventions during debridement (such as orchiectomy, penectomy, or colostomy), the type of wound dressing used (open wound dressing [OWD] or vacuum-assisted closure [VAC]), the number of debridement sessions, length of hospital stay, the requirement for grafting during wound closure, and mortality outcomes. These variables were analyzed based on hospital records. Results: VAC therapy was applied to 30 patients (50%). The mean age of patients in the VAC group was 63.1 +/- 11.7 years, compared to 65.2 +/- 12.1 years in the OWD group. The VAC group had a significantly shorter average hospital stay (15.17 +/- 9.19 days) than the OWD group (22.8 +/- 14.76 days) (p = 0.019). Additionally, the mean number of debridement sessions was significantly lower in the VAC group (3.27 +/- 2.15) compared to the OWD group (4.87 +/- 3.17) (p = 0.026). Conclusion: VAC therapy is an effective method for FG management, reducing debridement sessions and hospital stay compared to OWD.
C1 [Oner, Suleyman; Bekyurek, Utku; Ure, Iyimser; Yenilmez, Aydin] Eskisehir Osmangazi Univ, Fac Med, Dept Urol, Eskisehir, Turkiye.
   [Oner, Betul Altintas] Eskisehir City Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkiye.
C3 Eskisehir Osmangazi University
RP Öner, S (通讯作者)，Eskisehir Osmangazi Univ, Fac Med, Dept Urol, Eskisehir, Turkiye.
EM drsuleymanoner@gmail.com
OI Bekyürek, Utku/0009-0003-9589-0949
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD 2026 APR 30
PY 2026
DI 10.1111/ans.70712
EA APR 2026
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI0CQ
UT WOS:001754514500001
PM 42059775
DA 2026-07-24
ER
PT J
AU Zhao, YJ
   Wang, XK
   Song, JW
   Qu, ZJ
   Cao, GQ
   Wang, K
AF Zhao, Yujie
   Wang, Xiaokai
   Song, Jiwu
   Qu, Zhoujiang
   Cao, Guoqi
   Wang, Kun
TI Innovative Removal of Non-Marginally Exposed Hardware From the Frontal
   Region With Successful Wound Closure
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Dental high-speed handpiece; negative pressure wound therapy;
   non-marginal defects; scalp skin grafting; titanium mesh exposure
ID DECOMPRESSIVE CRANIECTOMY; DONOR SITE; CRANIOPLASTY; THERAPY; SCALP
AB Rationale:Titanium mesh is a common material for cranioplasty, but postoperative mesh exposure with infection poses a significant challenge-particularly for small, non-marginal defects where traditional instruments are ineffective.Patient concerns:A 41-year-old female developed an infected, non-marginal titanium mesh exposure in the frontal region 60 days after implantation, which followed traumatic brain injury surgery.Diagnoses:Open craniocerebral injury; open frontal bone fracture; focal cerebral contusion and laceration; status post-cranioplasty with titanium mesh; and exposure of frontal titanium mesh complicated by skin infection.Intervention:An innovative approach was used: (1) A dental high-speed handpiece (tungsten steel burr) was used to precisely resect the exposed mesh; (2) Negative pressure wound therapy was administered to promote granulation tissue formation; (3) A thin skin graft, harvested from the scalp, was transplanted in a second-stage procedure.Outcomes:The skin graft survived completely, with rapid healing at the donor site and no visible scarring. The wound closed fully, the infection resolved, and the aesthetic outcome was satisfactory.Lessons:For small, non-marginal titanium mesh exposure, the dental high-speed handpiece is an effective resection tool. When combined with scalp skin grafting, this protocol provides a simple, effective, and cosmetically favorable solution.
C1 [Wang, Xiaokai; Song, Jiwu; Cao, Guoqi; Wang, Kun] Shandong Second Med Univ, Weifang Peoples Hosp, Affiliated Hosp 1, Dept Burns & Wound Repair, Weifang, Shandong, Peoples R China.
   [Wang, Xiaokai; Cao, Guoqi] Shandong Second Med Univ, Clin Coll, Weifang, Shandong, Peoples R China.
   [Qu, Zhoujiang] Shandong Second Med Univ, Weifang Peoples Hosp, Affiliated Hosp 1, Dept Prosthodont, Weifang, Shandong, Peoples R China.
C3 Shandong Second Medical University; Shandong Second Medical University;
   Shandong Second Medical University
RP Cao, GQ; Wang, K (通讯作者)，Shandong Second Med Univ, Weifang Peoples Hosp, Affiliated Hosp 1, Dept Burns & Wound Repair, Weifang, Shandong, Peoples R China.; Cao, GQ (通讯作者)，Shandong Second Med Univ, Peoples Hosp, Affiliated Hosp 1, Dept Burns & Wound Repair, Weifang 261041, Shandong, Peoples R China.
EM 13965743207@163.com; 1317617818@qq.com; hckke@126.com;
   zhoujiangqu@163.com; clpguoqi@163.com; wangkun8192165@126.com
FU the Natural Science Foundation, Shandong Province [ZR2025QC1652] Funding
   Source: Medline
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD MAY
PY 2026
VL 37
IS 5
BP e431
EP e436
DI 10.1097/SCS.0000000000012435
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI4EK
UT WOS:001754791100006
PM 41603885
DA 2026-07-24
ER
PT J
AU Jang, HB
   Jung, EK
   Yoon, TM
   Lee, DH
   Lim, SC
   Lee, JK
AF Jang, Hye-Bin
   Jung, Eun Kyung
   Yoon, Tae Mi
   Lee, Dong Hoon
   Lim, Sang Chul
   Lee, Joon Kyoo
TI Efficiency of Endoluminal Vacuum-Assisted Closure Therapy for
   Pharyngocutaneous Fistula
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Cutaneous fistula; head and neck neoplasms; laryngoscopy;
   negative-pressure wound therapy; pharyngectomy
ID PRESSURE WOUND THERAPY; ORGAN PRESERVATION THERAPY; NEGATIVE-PRESSURE;
   TOTAL LARYNGECTOMY; ANASTOMOTIC LEAKAGE; HEAD; RADIATION; RESECTION
AB The aim of this study was to evaluate the efficacy of endoluminal vacuum-assisted closure (EndoVAC) therapy for patients with pharyngocutaneous fistula by placing a sponge in the intraluminal pharyngeal space using a transoral approach. The authors retrospectively enrolled 12 patients with pharyngocutaneous fistula, who were treated with EndoVAC therapy from 2023 to 2024. Of the 12 patients, 10 patients had pharyngocutaneous fistula after surgery for head and neck malignancy, 1 patient had a leak in the pharyngoesophageal junction caused by bougienage, and 1 patient had a pharyngocutaneous fistula associated with antiphospholipid syndrome. The average time for fistula detection after surgery was 7.27 +/- 1.68 days. Among the 12 patients, 5 patients were treated with EndoVAC alone, and 7 patients were treated with both EndoVAC and external negative pressure wound therapy (NPWT). The average number, duration, and an average change interval of EndoVAC procedures among all 12 patients was 2.91 +/- 0.41, 20.08 +/- 3.60 days, 6.87 +/- 0.39 days, respectively. All 12 cases of pharyngocutaneous fistula were successfully closed without additional reconstructive flap surgery. The mean time to fistula healing was 36.25 +/- 5.89 days. When the 10 patients who developed postoperative pharyngocutaneous fistula were divided into 2 groups based on whether preventive EndoVAC was performed or not, the time for improvement of the 5 patients who underwent preventive EndoVAC was 26.2 +/- 3.81 days. Whereas for 5 patients who did not, it was 43 +/- 10.33 days. EndoVAC is considered a straightforward and effective treatment for pharyngocutaneous fistula.
C1 [Lee, Joon Kyoo] Chonnam Natl Univ, Dept Otolaryngol Head & Neck Surg, Med Sch, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea.
   [Lee, Joon Kyoo] Hwasun Hosp, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea.
C3 Chonnam National University
RP Lee, JK (通讯作者)，Chonnam Natl Univ, Dept Otolaryngol Head & Neck Surg, Med Sch, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea.; Lee, JK (通讯作者)，Hwasun Hosp, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea.
EM hyebin117@hanmail.net; room804@naver.com; yoontm@jnu.ac.kr;
   leen3l@jnu.ac.kr; limsc@jnu.ac.kr; joonkyoo@jnu.ac.kr
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NR 31
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD MAY
PY 2026
VL 37
IS 5
BP 1213
EP 1216
DI 10.1097/SCS.0000000000011873
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI4FS
UT WOS:001754794600020
PM 40892052
DA 2026-07-24
ER
PT J
AU Trinh, SM
   Andre, K
   Özcan, AI
   Vitharana, DS
   Deville, PE
   Mason, JW
   Hunt, JP
   Marr, AB
   Greiffenstein, PP
   Stuke, LE
   Smith, AA
AF Trinh, Sophia M.
   Andre, Kaitlyn
   Ozcan, Ada I.
   Vitharana, Dhanushka S.
   Deville, Paige E.
   Mason, Joseph W.
   Hunt, John P.
   Marr, Alan B.
   Greiffenstein, Patrick P.
   Stuke, Lance E.
   Smith, Alison A.
TI Surgical management of stage 3 and 4 pressure injuries in trauma
   patients using ovine forestomach matrix grafts: a prospective case
   series
SO FRONTIERS IN SURGERY
LA English
DT Article
DE ovine forestomach matrix; pressure injury; surgical reconstruction;
   trauma; wound healing
ID WOUNDS
AB Introduction Stage 3 and 4 pressure injuries (PIs) pose significant challenges in trauma patients. Surgical management aims to support improvements in tissue vitality and often relies on debridement and negative pressure wound therapy. The use of ovine forestomach matrix (OFM)-based grafts to augment existing surgical approaches may improve tissue quality prior to reconstruction or closure by secondary intention.Methods This prospective observational study is part of a larger Institutional Review Board-approved study (Registry: ClinicalTrials.gov. Clinical trial number: NCT05243966). The study enrolled patients with Stage 3 and 4 PIs between July 2022 and July 2024 at a single level 1 trauma center. The study's primary endpoint was the incidence of postoperative complications and secondary endpoints included time to granulation tissue coverage and/or fill, percent area reduction, and number of OFM applications.Results Nine participants (eight men, one woman) with a total of 12 PIs (25% Stage 3 and 75% Stage 4) were enrolled in the study. The mean surface area was 46 +/- 24 cm2, and 10 of the 12 enrolled PIs included areas of tunneling and/or undermining. The median time to 50% granulation tissue was 2.0 (IQR: 1.5, 8.5) weeks and the median time to complete granulation tissue coverage was 6.5 (IQR: 2.0, 15.0) weeks. Tunneling or undermining was eradicated in 50% of PIs. The mean percent area reduction at the last recorded visit was 61% +/- 30%. There were no postoperative complications.Conclusion These results suggest that OFM-based grafts may serve as a valuable adjunct for the surgical management of late-stage PIs that are clinically challenging to heal.
C1 [Trinh, Sophia M.; Andre, Kaitlyn; Ozcan, Ada I.; Vitharana, Dhanushka S.; Deville, Paige E.; Mason, Joseph W.; Hunt, John P.; Marr, Alan B.; Greiffenstein, Patrick P.; Stuke, Lance E.; Smith, Alison A.] Louisiana State Univ, Hlth Sci Ctr, Dept Surg, New Orleans, LA 70802 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans
RP Smith, AA (通讯作者)，Louisiana State Univ, Hlth Sci Ctr, Dept Surg, New Orleans, LA 70802 USA.
EM alison.annette.smith@gmail.com
FU Aroa Biosurgery Limited (Auckland, New Zealand)
FX The author(s) declared that financial support was received for this work
   and/or its publication. Funding for the prospective registry
   (NCT05243966) is provided by Aroa Biosurgery Limited (Auckland, New
   Zealand). The funder was not involved in the study design, collection,
   analysis, interpretation of data, the writing of this article, or the
   decision to submit it for publication.
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD APR 20
PY 2026
VL 13
AR 1704665
DI 10.3389/fsurg.2026.1704665
EA APR 2026
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI5RJ
UT WOS:001754893700001
PM 42087918
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Révész, ES
   Montskó, V
   Altorjay, A
   Reich, V
   Jakab, G
   Hangody, L
AF Revesz, Erzsebet Szabone
   Montsko, Valeria
   Altorjay, Aron
   Reich, Viktor
   Jakab, Gabriella
   Hangody, Laszlo
TI Comparison of different sampling procedures in negative pressure wound
   therapy used in wound infections following reconstruction of abdominal
   wall hernias with mesh on homogeneous patient material
SO ORVOSI HETILAP
LA Hungarian
DT Article
DE wound infection; abdominal wall hernias with mesh; negative pressure
   therapy; wound infection; abdominal wall hernias with mesh; negative
   pressure therapy
AB Introduction: The repair of postoperative abdominal hernias remains a challenge to this day, even though the surgery is sterile. Wound infection is a problem, which is exacerbated by the comorbidity of the patient population. The incorporation of foreign material always carries a risk of infection. In the event of wound infection, the possibility of hernia recurrence is 0.2-8%, while if the mesh also needs to be removed, the probability of recurrence is over 30%. Compared to open wound treatment, negative pressure therapy is more effective in promoting wound healing and preserving the implanted mesh. Materials and methods: In our study, we analyze the cases of a total of 30 patients who underwent onlay mesh abdominal hernia surgery between 2015 and 2023, during which wound dehiscence occurred. In all cases, wound exudate culture and negative pressure wound therapy were performed. In 15 patients, swab samples were taken, while in the other 15, swab, sponge, and tissue roller samples were taken. Swab samples mainly revealed skin flora, which was Gram-positive in 71% of cases. The results of the tissue roller and sponge swab cultures showed Gram-negative pathogens in 50% of cases. Results: The sponge swab and tissue roller cultures provided additional information on the bacterial load. Negative pressure wound therapy meant that the mesh did not need to be removed. Conclusion: During negative pressure wound therapy, cultures taken using multiple methods also helped in the selection of antibiotics. Vacuum therapy used for mesh removal reduces bacterial load and accelerates granulation. Hernia recurrence and mesh removal are significantly reduced.
C1 [Revesz, Erzsebet Szabone; Altorjay, Aron; Reich, Viktor] Fejer Varmegyei Szent Gyorgy Egyet Oktato Korhaz, Sebeszeti Osztaly, Szekesfehervar, Hungary.
   [Montsko, Valeria] Fejer Varmegyei Szent Gyorgy Egyet Oktato Korhaz, Szeptikus Osztaly, Szekesfehervar, Hungary.
   [Jakab, Gabriella] Fejer Varmegyei Szent Gyorgy Egyet Oktato Korhaz, Mikrobiol Lab, Szekesfehervar, Hungary.
   [Hangody, Laszlo] Uzsok Utcai Korhaz, Traumatol Ortopediai Osztaly, Budapest, Hungary.
   [Hangody, Laszlo] Semmelweis Egyet, Altalanos Orvostud Kar, Traumatol Tanszek, Budapest, Hungary.
C3 Semmelweis University
RP Révész, ES (通讯作者)，Neumann J U 21, H-8000 Szekesfehervar, Hungary.
EM revesze1978@gmail.com
CR American Association of Textile Chemists and Colorists, 2019, TM100TM 100 TEST MET
   Berner-Hansen V, 2021, HERNIA, V25, P1481, DOI 10.1007/s10029-021-02485-7
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   National Institute for Health and Care Excellence, SURG SITE INFECT PRE
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0030-6002
EI 1788-6120
J9 ORVOSI HETILAP
JI Orvosi Hetilap
PD MAY 3
PY 2026
VL 167
IS 18
BP 714
EP 721
DI 10.1556/650.2026.33543
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HJ3YH
UT WOS:001755455700001
PM 42070235
OA hybrid
DA 2026-07-24
ER
PT J
AU Shuler, MS
   Mowers, CC
   Dhodapkar, MM
   Greenberg, M
   Ngendahimana, D
   Freedman, BA
AF Shuler, Michael S.
   Mowers, Colton C.
   Dhodapkar, Meera M.
   Greenberg, Mitchell
   Ngendahimana, David
   Freedman, Brett A.
TI Contact Pressure Under Traditional Foam and Novel Thermoplastic
   Elastomer Negative Pressure Wound Therapy Interfaces
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE contact pressure; deep wound; foam dressing; negative pressure wound
   therapy; porcine explant; pressure mapping; pressure transduction;
   thermoplastic elastomer; wound filler; wound perfusion
ID MICROVASCULAR BLOOD-FLOW; VACUUM-ASSISTED CLOSURE; LASER-DOPPLER;
   CONTRACTION; GAUZE; TRANSDUCTION
AB Negative pressure wound therapy relies on suction, commonly set to -125 mmHg, to evacuate wound fluid, but dysvascular and pressure injuries often respond unpredictably. Newton's third law indicates that negative pressure applies an equal and opposite contact pressure on the wound surface, and this study quantified this contact pressure across dressing types, wound configurations and suction levels. Using a porcine explant model, central and peripheral contact pressure measurements were obtained beneath black reticulated open cell foam, white foam and a novel thermoplastic elastomer dressing across plexiglass, intact skin, shallow and deep wounds under -50, -75 and -125 mmHg. Contact pressure increased proportionally with negative pressure, and multivariable modelling demonstrated that dressing type, wound type and suction level significantly influenced pressure, with negative pressure explaining most of the variance (0.77 and 0.68). Thermoplastic elastomer at -50 mmHg in deep wounds produced the lowest contact pressure, whereas black reticulated open cell foam and white foam at -125 mmHg generated elevated contact pressures of approximately +125 to +195 mmHg. These findings show that black reticulated open cell foam at conventional -125 mmHg can create hypoperfusion conditions, whereas thermoplastic elastomer consistently produces the lowest pressures and may enhance perfusion at lower suction levels, offering a physiologic explanation for improved clinical outcomes in dysvascular and pressure injuries treated with reduced negative pressure.
C1 [Shuler, Michael S.] Athens Orthoped Clin, Athens, GA 30606 USA.
   [Mowers, Colton C.] Rush Univ, Med Ctr, Chicago, IL USA.
   [Dhodapkar, Meera M.; Freedman, Brett A.] Mayo Clin, Dept Orthoped Surg, Rochester, MN USA.
   [Greenberg, Mitchell] Geneva Fdn, Tacoma, WA USA.
   [Ngendahimana, David] Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland Hts, OH USA.
C3 Rush University; Mayo Clinic; University Hospitals of Cleveland; Rainbow
   Babies & Children's Hospital; University System of Ohio; Case Western
   Reserve University; Case Western Reserve University Hospital
RP Shuler, MS (通讯作者)，Athens Orthoped Clin, Athens, GA 30606 USA.
EM mshuler@ccthera.com
CR Allen D, 2023, WOUND REPAIR REGEN, V31, P349, DOI 10.1111/wrr.13084
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   Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
   Borgquist O, 2010, PLAST RECONSTR SURG, V125, P502, DOI 10.1097/PRS.0b013e3181c82e1f
   Detry MA, 2016, JAMA-J AM MED ASSOC, V315, P407, DOI 10.1001/jama.2015.19394
   Dhodapkar M. M., PRES 12 ANN UPMC S P
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   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
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   Lindstedt S, 2015, INT WOUND J, V12, P83, DOI 10.1111/iwj.12056
   Lindstedt S, 2012, BMC SURG, V12, DOI 10.1186/1471-2482-12-4
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nuutila K, 2025, INT WOUND J, V22, DOI 10.1111/iwj.70144
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   Nuutila K, 2019, WOUND REPAIR REGEN, V27, P162, DOI 10.1111/wrr.3
   Orlov A, 2021, MED ENG PHYS, V89, P33, DOI 10.1016/j.medengphy.2021.02.001
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   Wilkes R, 2009, J BIOMECH ENG-T ASME, V131, DOI 10.1115/1.2947358
NR 31
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR
PY 2026
VL 34
IS 2
AR e70157
DI 10.1111/wrr.70157
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA HK4EY
UT WOS:001756152700016
PM 41992494
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Marchand, LS
   Slobogean, G
   O'Hara, NN
   Harris, AD
   Grainger, DW
   Thabane, L
   Bhandari, M
   Della Rocca, GJ
   Kellam, PJ
   Zura, RD
   Marvel, D
   Wells, JL
   Gitajn, IL
   Jeray, KJ
   O'Toole, RV
   Working, ZM
   Natoli, RM
   Bergin, PF
   Hagen, JE
   Levack, AE
   Guerra-Farfan, E
   Schrank, GM
   Hebden, JN
   Mossuto, F
   Tsoutsounakis, C
   Pogorzelski, D
   Pineda, H
   Bzovsky, S
   Sprague, S
AF Marchand, Lucas S.
   Slobogean, Gerard
   O'Hara, Nathan N.
   Harris, Anthony D.
   Grainger, David W.
   Thabane, Lehana
   Bhandari, Mohit
   Della Rocca, Gregory J.
   Kellam, Patrick J.
   Zura, Robert D.
   Marvel, Debra
   Wells, Jeffrey L.
   Gitajn, I. Leah
   Jeray, Kyle J.
   O'Toole, Robert, V
   Working, Zachary M.
   Natoli, Roman M.
   Bergin, Patrick F.
   Hagen, Jennifer E.
   Levack, Ashley E.
   Guerra-Farfan, Ernesto
   Schrank, Gregory M.
   Hebden, Joan N.
   Mossuto, Franca
   Tsoutsounakis, Cassandra
   Pogorzelski, David
   Pineda, Hailey
   Bzovsky, Sofia
   Sprague, Sheila
CA BvV Investigators
TI Randomised controlled trial comparing antibiotic cement bead pouch
   versus negative pressure wound therapy for the management of severe open
   tibia fracture wounds: Beads versus VAC (BvV) protocol
SO BMJ OPEN
LA English
DT Article
DE ORTHOPAEDIC & TRAUMA SURGERY; Adult orthopaedics; Trauma management
ID LOADED ACRYLIC CEMENT; SURGICAL SITE INFECTIONS; ACUTE KIDNEY INJURY;
   IN-VITRO ELUTION; QUALITY-OF-LIFE; BONE-CEMENT; PROSTHESIS; RELEASE;
   POWDER; ARTHROPLASTY
AB Introduction Early open fracture management aims to minimise the risk of complications. For the most severe open fracture wounds, multiple irrigation and debridement surgeries are required to overcome severe wound contamination, to reassess the evolving tissue injury or to temporise and plan further surgery. When multiple irrigation and debridement surgeries are needed, uncertainty remains about how the open fracture wound should be managed to best minimise complications. The primary aim of this trial is to compare the antibiotic cement bead pouch vs negative pressure wound therapy in the management of patients with severe open tibia fracture wounds.<br /> Methods and analysis BvV is a multicentre, pragmatic, parallel arm randomised controlled trial that aims to enrol 312 adult patients admitted to a participating centre with a severe open tibia fracture requiring multiple irrigation and debridement surgeries. Participants will be randomly allocated on a 1:1 basis to either antibiotic cement bead pouch or negative pressure wound therapy. The primary outcome will be a composite outcome to evaluate clinical status 6 months after randomisation. Using the win ratio approach, we will hierarchically assess the composite outcome in the following order: (i) all-cause mortality, (ii) injury-related amputation of the lower extremity, (iii) unplanned reoperation to manage wound complications, an infection or promote fracture healing and (iv) clinical fracture healing assessed using the Functional IndeX for Trauma (FIX-IT) instrument.<br /> Ethics and dissemination The BvV trial has been approved by a central institutional review board (IRB) (Advarra) for clinical sites in the USA, the ethics board at the coordinating centre at McMaster University (Hamilton Integrated Research Ethics Board), and participating sites not using the central institutional IRB (Fraser Health Research Ethics Board, The University of British Columbia Clinical Research Ethics Board, Newfoundland and Labrador Health Research Ethics Board, University of Manitoba Biomedical Research Ethics Board). Additional clinical sites who are in the start-up phase, as well as any new selected clinical sites, will obtain local approvals prior to initiating trial activities. This will include a clinical site in the UK who is in the process of obtaining the necessary approvals. Recruitment began in November 2023. Both interventions are frequently used to manage severe open fracture wounds, ensuring that the trial results can be easily transitioned into clinical practice. The results of this trial will be disseminated to national and international partners through peer-reviewed publications, academic conferences and stakeholder engagement activities.
C1 [Marchand, Lucas S.] Univ Utah, Dept Orthopaed Surg, Salt Lake City, UT 84112 USA.
   [Slobogean, Gerard] Univ Calif Irvine, Dept Orthoped Surg, Orange, CA USA.
   [O'Hara, Nathan N.; O'Toole, Robert, V] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Ctr Orthopaed Injury Res & Innovat, Dept Orthopaed,Sch Med, Baltimore, MD USA.
   [Harris, Anthony D.; Hebden, Joan N.] Univ Maryland, Dept Epidemiol & Publ Hlth, Sch Med, Baltimore, MD USA.
   [Grainger, David W.] Univ Utah, Dept Biomed Engn, Salt Lake City, UT USA.
   [Thabane, Lehana] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada.
   [Bhandari, Mohit; Pogorzelski, David; Pineda, Hailey; Bzovsky, Sofia; Sprague, Sheila] McMaster Univ, Dept Surg, Div Orthopaed Surg, Hamilton, ON, Canada.
   [Della Rocca, Gregory J.] Univ Missouri, Dept Orthopaed Surg, Columbia, MO USA.
   [Kellam, Patrick J.] UTHealth Houston, McGovern Med Sch, Dept Orthoped Surg, Houston, TX USA.
   [Zura, Robert D.] LSUHSC Orthopaed New Orleans, New Orleans, LA USA.
   [Marvel, Debra; Wells, Jeffrey L.] Univ Maryland Baltimore, Patient Representat, Baltimore, MD USA.
   [Gitajn, I. Leah] Dartmouth Hitchcock Med Ctr, Dept Orthopaed Surg, Lebanon, NH USA.
   [Jeray, Kyle J.] Univ South Carolina, Dept Orthoped Surg, Prisma Hlth Upstate, Greenville, SC USA.
   [Working, Zachary M.] Oregon Hlth & Sci Univ, Dept Orthopaed & Rehabil, Portland, OR USA.
   [Natoli, Roman M.] IU Methodist Hosp, Dept Orthopaed Surg, Div Orthopaed Trauma, Indianapolis, IN USA.
   [Bergin, Patrick F.] Univ Mississippi, Dept Orthopaed Surg & Rehabil, Med Ctr, Jackson, MS USA.
   [Hagen, Jennifer E.] Univ Florida, Dept Orthopaed Surg & Sports Med, Div Orthopaed Trauma, Gainesville, FL USA.
   [Levack, Ashley E.] Loyola Univ Med Ctr, Dept Orthopaed Surg & Rehabil, Maywood, IL USA.
   [Levack, Ashley E.] Stritch Sch Med, Maywood, IL USA.
   [Guerra-Farfan, Ernesto] Hosp Univ Vall dHebron, Dept Orthoped Surg & Traumatol, Barcelona, Spain.
   [Schrank, Gregory M.] Univ Maryland, Dept Med, Div Infect Dis, Sch Med, Baltimore, MD USA.
   [Mossuto, Franca] Hamilton Hlth Sci Hosp, Div Orthopaed Surg, Gen Site, Hamilton, ON, Canada.
   [Tsoutsounakis, Cassandra] Univ Utah Hosp, Salt Lake City, UT USA.
   [Sprague, Sheila] Johns Hopkins Univ, Dept Plast & Reconstruct Surg, Baltimore, MD USA.
C3 Utah System of Higher Education; University of Utah; University of
   California System; University of California Irvine; University System of
   Maryland; University of Maryland Baltimore; University System of
   Maryland; University of Maryland Baltimore; Utah System of Higher
   Education; University of Utah; McMaster University; McMaster University;
   University of Missouri System; University of Missouri Columbia;
   University System of Maryland; University of Maryland Baltimore;
   Dartmouth College; Prisma Health; Oregon Health & Science University;
   University of Mississippi; University of Mississippi Medical Center;
   State University System of Florida; University of Florida; Loyola
   University Chicago; Loyola University Chicago; Hospital Universitari
   Vall d'Hebron; University System of Maryland; University of Maryland
   Baltimore; Utah System of Higher Education; University of Utah;
   University of Utah Hospital; Johns Hopkins University
RP Marchand, LS (通讯作者)，Univ Utah, Dept Orthopaed Surg, Salt Lake City, UT 84112 USA.
EM lucas.marchand@hsc.utah.edu; gslobogean@som.umaryland.edu;
   NO'Hara@som.umaryland.edu; aharris@som.umaryland.edu;
   david.grainger@utah.edu; thabanl@mcmaster.ca; bhandam@mcmaster.ca;
   dellaroccag@health.missouri.edu; patrick.j.kellam@uth.tmc.edu;
   rzura@lsuhsc.edu; debramarvel@comcast.net; wellsjl@gmail.com;
   Ida.Leah.Gitajn@Hitchcock.ORG; kyle.jeray@prismahealth.org;
   ROtoole@som.umaryland.edu; workingz@ohsu.edu; rnatoli@iuhealth.org;
   pbergin@umc.edu; hagenje@ortho.ufl.edu; ashley.levack@lumc.edu;
   ernestoguerraf@gmail.com; gschrank@som.umaryland.edu;
   jhebden@som.umaryland.edu; francamossuto25@gmail.com;
   Cassi.Tsoutsounakis@hsc.utah.edu; pogorzd@mcmaster.ca;
   pinedh1@mcmaster.ca; bzovskys@mcmaster.ca; sprags@mcmaster.ca
RI OToole, Robert/HKN-8717-2023; Guerra-Farfan, Ernesto/D-4732-2012;
   Natoli, Roman/AAE-6397-2022; Working, Zachary/AAT-6760-2021; Della
   Rocca, Gregory/AAM-5281-2021; Wells, Jeffrey/AAQ-4232-2021
OI Kommu, Karan/0009-0001-9196-3202; Pineda, Hailey/0009-0001-7648-9135;
   Schrank, Gregory/0000-0002-3013-139X; Wells, Jeffrey/0000-0001-5032-0836
FU US Department of Defense Peer-Reviewed Orthopaedic Research Program
   [W81XWH]
FX This trial is funded by the US Department of Defense Peer-Reviewed
   Orthopaedic Research Program (W81XWH-22-1-0863). The funder of the trial
   had no role in the trial design or writing of the protocol.
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NR 50
TC 0
Z9 0
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY 28
PY 2026
VL 16
IS 5
AR e088521
DI 10.1136/bmjopen-2024-088521
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HK5XA
UT WOS:001756268500001
PM 42082225
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lin, HS
   Zhang, B
   Wang, YH
   Li, B
   Ren, BX
   Liu, CH
AF Lin, Hai-Shan
   Zhang, Bo
   Wang, Yao-Hua
   Li, Bo
   Ren, Bo-Xuan
   Liu, Chang-Hao
TI Limb Salvage in Infected Tibial Nonunion with Bone Loss: A Case Report
   of a Modified Masquelet-Ilizarov Technique
SO ACTA ORTHOPAEDICA BELGICA
LA English
DT Article
DE Masquelet Technique; Ilizarov External Fixator; Bone Transport; Bone
   Infection; Bone Defect; Open fractures
ID TRANSPORT; FRACTURES; MANAGEMENT; AMPUTATION; DEFECTS
AB Gustilo-Anderson type III fractures, characterized by extensive soft-tissue damage, require urgent debridement and external fixation to minimize infection risk. Despite these measures, deep infections and osteomyelitis may still develop, sometimes leading to amputation. The Masquelet and Ilizarov techniques have emerged as effective approaches for reconstructing infected bone defects by promoting bone regeneration and soft-tissue healing. A 57-year-old male sustained a Gustilo-Anderson type IIIB open tibial-fibular fracture with severe soft-tissue injury in a traffic accident. Initial treatment included emergency debridement, external fixation, and vacuum sealing drainage (VSD). However, he developed a progressive infection with extensive soft-tissue necrosis and osteomyelitis. A modified Masquelet-Ilizarov technique was employed, involving necrotic bone resection, antibiotic cement spacer implantation, and subsequent bone transport using an Ilizarov frame. At final follow-up, satisfactory bone union and functional limb recovery were achieved.The combined Masquelet-Ilizarov technique offers a viable limb-salvage strategy for infected Gustilo-Anderson type IIIB tibial fractures with bone loss, yielding acceptable clinical and functional outcomes.
C1 [Lin, Hai-Shan; Zhang, Bo; Wang, Yao-Hua; Li, Bo; Ren, Bo-Xuan; Liu, Chang-Hao] Hexi Univ, Affiliated Zhangye Peoples Hosp, Zhangye 734000, Gansu, Peoples R China.
   [Wang, Yao-Hua] Hexi Univ, Affiliated Zhangye Peoples Hosp, Dept Orthoped, 67 Xihuan Rd, Zhangye 734000, Gansu, Peoples R China.
C3 Hexi University; Hexi University
RP Wang, YH (通讯作者)，Hexi Univ, Affiliated Zhangye Peoples Hosp, Dept Orthoped, 67 Xihuan Rd, Zhangye 734000, Gansu, Peoples R China.
EM 1269182095@qq.com
RI ; Lin, Haishan/ACP-2775-2022
OI Lin, Haishan/0000-0001-5356-4211; 
FU President's Fund of Hexi University [2025YB043]
FX Supported by: President's Fund of Hexi University (2025YB043) .
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU ACTA MEDICA BELGICA
PI BRUSSELS
PA AVENUE WINSTON CHURCHILL, WINSTON CHURCHILL-LAAN, 11 BOX 30, B-1180
   BRUSSELS, BELGIUM
SN 0001-6462
J9 ACTA ORTHOP BELG
JI Acta Orthop. Belg.
PD MAR
PY 2026
VL 92
AR 15229
DI 10.52628/92.1.15229
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HK7CV
UT WOS:001756351500001
PM 42012051
DA 2026-07-24
ER
PT J
AU Sun, SQ
   Zhu, MT
   Wen, CH
AF Sun, Shaoqin
   Zhu, Mengting
   Wen, Changhui
TI Probable pyoderma gangrenosum complicated with cutaneous Aspergillus
   flavus infection: case report
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE <italic>Aspergillus flavus</italic>; cutaneous aspergillosis; negative
   pressure wound therapy; pyoderma gangrenosum; voriconazole
ID PRESSURE WOUND THERAPY
AB Pyoderma gangrenosum (PG) is a rare, chronic, autoinflammatory neutrophilic dermatosis. Its typical clinical manifestations include painful papules and pustules surrounded by erythema on the lower extremities and trunk, which gradually progress to form well-demarcated, painful ulcers with undermined edges. Due to impaired skin barrier function, prolonged wound exposure, and the frequent need for immunosuppressive therapy, PG patients are highly susceptible to secondary infections. We report here a clinical case of successful treatment with glucocorticoids and voriconazole, combined with multiple sessions of negative-pressure wound therapy and skin grafting, in a patient with cutaneous Aspergillus flavus infection and possible pyoderma gangrenosum.
C1 [Sun, Shaoqin; Wen, Changhui] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Dermatol, Guiyang, Guizhou, Peoples R China.
   [Zhu, Mengting] Guizhou Univ Tradit Chinese Med, Guiyang, Guizhou, Peoples R China.
C3 Guizhou University of Traditional Chinese Medicine; Guizhou University
   of Traditional Chinese Medicine
RP Wen, CH (通讯作者)，Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Dermatol, Guiyang, Guizhou, Peoples R China.
EM wenchanghui163@163.com
CR Biermann N, 2023, J TISSUE VIABILITY, V32, P613, DOI 10.1016/j.jtv.2023.06.010
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   Merad Y, 2021, PATHOGENS, V10, DOI 10.3390/pathogens10060643
   Moltrasio C, 2025, SEMIN IMMUNOPATHOL, V47, DOI 10.1007/s00281-025-01064-7
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   Suoniemi L, 2024, INT WOUND J, V21, DOI [10.1111/iwj.14943, 10.1111/iwj.14943]
NR 9
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD APR 22
PY 2026
VL 13
AR 1806433
DI 10.3389/fmed.2026.1806433
EA APR 2026
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HL2LB
UT WOS:001756711200001
PM 42100284
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Johnson, C
   Spitzer, M
   Berry, S
   Minton, J
AF Johnson, Connie
   Spitzer, Mandy
   Berry, Sophie
   Minton, Jonathan
TI Clinician decision-making for transitioning to single-use negative
   pressure wound therapy: analysis of real-world practice in an acute
   setting
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE acute care; chronic wounds; hard-to-heal wounds; negative pressure wound
   therapy; NPWT; single-use negative pressure wound therapy; wound; wound
   care; wound dressing; wound healing
ID CONSENSUS PANEL RECOMMENDATIONS; COMPENDIUM; BURDEN; IMPACT; CARE
AB Objective: Despite the widespread adoption of traditional negative pressure wound therapy (tNPWT) to improve clinical outcomes for hard-to-heal (chronic) wounds and the increasing availability of single-use systems that improve patient acceptability, there is limited evidence published about when to use each type of system to optimise treatment pathways. The aim of this retrospective case review was to evaluate those wounds transitioned from tNPWT to single-use NPWT (sNPWT) in a real-world, acute care setting and review clinical outcomes, thereby informing future practice approaches. Method: A retrospective chart review of the treatment pathway and clinical outcomes of all patients with wounds managed using NPWT presenting at a single, acute care hospital in the US from February 2023 to September 2024 was conducted. Initial tNPWT was administered continually at either-80mmHg or-120mmHg for all wounds. Wound characteristics and healing outcomes for patients transitioned from tNPWT to sNPWT during the course of treatment were reviewed. Results: Electronic medical records of 27 patients (12 females, 15 males; with 70% aged 36-75 years) with wounds that were eligible for treatment with NPWT were available for review. Mean duration of tNPWT and sNPWT was 9.8 +/- 11.1 days (median: 7 days; range:3-60 days). Estimated daily mean wound area reduction was 5.8% (median value: 3.2%) with similar improvements noted for wound volume. Of the 27 wounds treated with tNPWT, eight were successfully transitioned to sNPWT once a sustained healing trajectory had been achieved. No wounds received first-line treatment with sNPWT, despite many of the wounds potentially being suitable for this approach. Conclusion: Approximately 30% of wounds included in this review were considered eligible for transition from tNPWT to sNPWT, facilitating earlier hospital discharge without compromising clinical outcomes. More widespread adoption of sNPWT, and even first-line use for appropriate wounds, may help to reduce hospital stay while maintaining effective wound management, thereby improving the patient experience, hospital efficiency and resource utilisation. Declaration of interest: Smith+Nephew, UK, provided funding to enable CJ to collect real-world data on the standard of care use of the NPWT systems used and Smith+Nephew provided support with statistical analysis of the results. Smith+Nephew had no role in patient management or clinical decision-making. CJ received a fee from Smith+Nephew to review and publish the clinical cases. SB, MS and JM are Smith+Nephew employees.
C1 [Johnson, Connie] Penn Med, Princeton Med Ctr, Plainsboro, NJ USA.
   [Spitzer, Mandy; Berry, Sophie] Smith Nephew, Global Clin Strategy, Global Clin & Med Affairs, Watford, England.
   [Minton, Jonathan] Smith Nephew, Global Clin & Med Affairs, Global Biostat, Watford, England.
C3 University of Pennsylvania; Pennsylvania Medicine
RP Berry, S (通讯作者)，Smith Nephew, Global Clin Strategy, Global Clin & Med Affairs, Watford, England.
EM sophie.berry@smith-nephew.com
CR Agency for Healthcare Research and Quality, 2021, AHRQ PUBLICATION, V21-EHC015
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   Sen CK, 2019, ADV WOUND CARE, V8, P39, DOI 10.1089/wound.2019.0946
   Suissa D, 2011, PLAST RECONSTR SURG, V128, p498E, DOI 10.1097/PRS.0b013e31822b675c
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   World Union of Wound Healing Societies, 2019, WUWHS CONSENSUS DOCU
NR 31
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2026
VL 35
IS 5
BP 400
EP 408
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HO6KM
UT WOS:001759018800001
PM 42060505
DA 2026-07-24
ER
PT J
AU Chen, P
   Wang, L
   Gao, SF
   Ji, JF
   Gong, ZH
AF Chen, Peng
   Wang, Lu
   Gao, ShengFeng
   Ji, JianFeng
   Gong, ZhenHua
TI Observational study on the therapeutic effects of two different negative
   pressure drainage devices on skin graft donor sites
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Intermediate-thickness skin graft; Donor site; VSD; VAC
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; BLOOD-FLOW
AB Objective To conduct a retrospective analysis of patients who received treatment with two types of negative pressure materials for intermediate-thickness skin graft donor sites, comparing the clinical efficacy and exploring potential mechanisms. Methods According to the case inclusion criteria, a total of 55 patients hospitalized for surgery requiring autologous skin grafting between 2023 and 2024 were selected. Among them, 20 patients were treated with VAC (Group A), 20 with VSD (Group B), and another 15 patients (Group C) did not receive negative pressure device therapy; instead, their wounds were covered with sterile fine-mesh Vaseline gauze postoperatively, followed by sterile gauze and regular dressing changes. Data recorded included: drainage volume per square centimeter within the first 3 postoperative days for Groups A and B; occlusion of the external drainage tube; presence of active bleeding; skin itching and blisters in the film and negative pressure material coverage area; VAS scores of the donor sites on the first 3 postoperative days and at the time of negative pressure dressing removal for all three groups (A, B, C); and the total complete healing time. Original data were recorded. Results No cases of infection or active bleeding occurred before complete epithelialization healing in any of the three groups (A, B, C); 14 cases of occlusion occurred in the external drainage tubes of the VSD group, all of which were cleared by flushing with sterile water for injection within 3 h of occlusion; a small number of cases in both Groups A and B experienced varying degrees of blisters and itching; the mean time to complete epithelialization was shorter in the negative pressure groups compared to Group C (p < 0.05), but there was no significant difference between Groups A and B (p > 0.05); the drainage volume per square centimeter in the first 3 postoperative days showed no significant difference between the negative pressure groups (p > 0.05); regarding VAS scores for the donor sites in the first 3 days, the negative pressure groups showed significant differences on days 1 and 2 (p < 0.05), but no significant difference on day 3. The VAS scores of both Groups A and B were statistically significantly different from Group C (p < 0.05). Conclusion Both VAC (polyurethane) and VSD (polyvinyl alcohol) negative pressure drainage devices can shorten the healing time window for intermediate-thickness skin graft donor sites; within the limitations of this retrospective study, patients in the VAC group tolerated and cooperated better during the treatment of the donor site. These findings require validation in prospective randomized controlled trials.
C1 [Chen, Peng; Wang, Lu; Gao, ShengFeng; Ji, JianFeng; Gong, ZhenHua] Nantong Univ, Affiliated Hosp 2, Nantong Peoples Hosp 1, Nantong, Peoples R China.
C3 Nantong University; Southeast University - China
RP Gong, ZH (通讯作者)，Nantong Univ, Affiliated Hosp 2, Nantong Peoples Hosp 1, Nantong, Peoples R China.
EM 1543338532@qq.com
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD AUG
PY 2026
VL 35
IS 3
AR 101005
DI 10.1016/j.jtv.2026.101005
EA MAY 2026
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA HT6UL
UT WOS:001762435500001
PM 42070549
OA hybrid
DA 2026-07-24
ER
PT J
AU Tedesco, S
   Di Grezia, M
   Altieri, G
   Cina, C
   Fico, V
   Misuriello, F
   Bracalente, G
   Piras, E
   Brisinda, G
AF Tedesco, Silvia
   Di Grezia, Marta
   Altieri, Gaia
   Cina, Caterina
   Fico, Valeria
   Misuriello, Filomena
   Bracalente, Giada
   Piras, Edoardo
   Brisinda, Giuseppe
TI Results of surgical treatment of necrotizing soft tissue infections. A
   15-years retrospective cohort study of a single center of emergency
   surgery
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Debridement; Humans; Necrosis; Soft Tissue Infections; Risk factors;
   Surgery
ID PRESSURE WOUND THERAPY; ACUTE PHYSIOLOGY; LIMB LOSS; SKIN; MANAGEMENT;
   MORTALITY; SCORE; CLASSIFICATION; PREDICTORS; GUIDELINES
AB Background Although rare, necrotizing soft tissue infections carries a high risk of mortality and morbidity. Extensive surgical debridement of necrotic tissues until healthy tissue is the cornerstone of management. Despite this, in-hospital mortality remains high for these patients. Methods We evaluated the experience of an Emergency Surgery center over a 15-year period. We evaluated factors related to in-hospital mortality. Secondary outcomes were assessment of morbidity, need for intensive care admission, risk of amputation, and outcomes related to the timing of surgery. Results One hundred and eight patients were included in this retrospective cohort study. All patients, except one (99.1%), underwent surgical debridement. Of these, 64 patients (59.3%) required multiple revisions (2.0 +/- 2.7). Negative pressure wound therapy was applied to 52 patients (48.1%), for a mean duration of 21.7 +/- 23.3 days. The mortality rate was 25.9% (28 patients). Ninety patients (83.3%) developed a complication during hospitalization, most of which were severe (20 patients grade III and 64 grade IV). Patients operated on within 10 h experienced a reduction in the rate of major complications (P = 0.02). Fourteen patients (13%) underwent limb amputation and 37 patients (34.3%) presented motor deficits at discharge. Conclusions Necrotizing soft tissue infections are a challenge for the emergency surgeon. An accurate diagnosis is not always possible and rapid intervention improves the results. Currently, there are no elements that allow a definitive diagnosis and a determining factor for a correct and accurate diagnostic framework is the competence of the surgeon.
C1 [Tedesco, Silvia; Di Grezia, Marta; Altieri, Gaia; Cina, Caterina; Fico, Valeria; Misuriello, Filomena; Bracalente, Giada; Piras, Edoardo; Brisinda, Giuseppe] IRCCS, Fdn Policlin Univ Gemelli, Emergency Surg & Trauma Ctr, I-00168 Rome, Italy.
   [Tedesco, Silvia] IRCCS, Fdn Policlin Univ Gemelli, Thorac Surg, I-00168 Rome, Italy.
   [Misuriello, Filomena; Bracalente, Giada; Piras, Edoardo; Brisinda, Giuseppe] Catholic Sch Med Agostino Gemelli, I-00168 Rome, Italy.
   [Brisinda, Giuseppe] IRCCS, Fdn Policlin Univ Gemelli, Dept Med & Surg Sci, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; Catholic University of the
   Sacred Heart; Catholic University of the Sacred Heart
RP Brisinda, G (通讯作者)，IRCCS, Fdn Policlin Univ Gemelli, Emergency Surg & Trauma Ctr, I-00168 Rome, Italy.; Brisinda, G (通讯作者)，Catholic Sch Med Agostino Gemelli, I-00168 Rome, Italy.; Brisinda, G (通讯作者)，IRCCS, Fdn Policlin Univ Gemelli, Dept Med & Surg Sci, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
EM giuseppe.brisinda@policlinicogemelli.it
RI ; Brisinda, Giuseppe/G-6436-2010; Fico, Valeria/KUF-2684-2024
OI Piras, Edoardo/0009-0002-0967-1719; Bracalente,
   Giada/0009-0002-4596-2644; 
FU Universit Cattolica del Sacro Cuore
FX Open access funding provided by Universita Cattolica del Sacro Cuore
   within the CRUI-CARE Agreement.
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NR 64
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD MAR 31
PY 2026
VL 411
IS 1
AR 132
DI 10.1007/s00423-026-04038-x
EA MAR 2026
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HU0IM
UT WOS:001762674900001
PM 41915240
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Manasrah, A
   Ayyad, A
   Abu Suilik, H
   Zibara, Z
   Alalawneh, A
   Bataineh, Z
   Rjoub, S
   Al Akash, MA
   Tanashat, M
AF Manasrah, AlMothana
   Ayyad, Alaa
   Abu Suilik, Husam
   Zibara, Zahraa
   Alalawneh, Alshayma
   Bataineh, Zaid
   Rjoub, Samah
   Al Akash, Minnat Allah
   Tanashat, Mohammad
TI Negative Pressure Wound Therapy Versus Standard Dressings for Preventing
   Surgical Site Infections Following Abdominal Surgery: A Systematic
   Review and Meta-Analysis of Randomized Controlled Trials
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
DE abdominal surgery; meta-analysis; negative pressure wound therapy;
   randomized controlled trials; surgical site infection; wound management
ID IMPACT; COSTS
AB Background Surgical site infections (SSIs) are among the most frequent postoperative complications, contributing significantly to patient morbidity, prolonged hospital stays, and increased healthcare costs. Prophylactic negative pressure wound therapy (ciNPWT) has emerged as a potential strategy to reduce SSIs, particularly in abdominal surgery, but its effectiveness remains debated.Objective To evaluate the effectiveness of ciNPWT in reducing SSI rates and other surgical outcomes following abdominal surgery by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).Methods We performed a comprehensive meta-analysis of RCTs assessing the use of ciNPWT versus standard wound care in abdominal surgeries including mixed wound contamination classes (e.g., clean-contaminated to contaminated/dirty procedures). The protocol was registered with PROSPERO (https://www.crd.york.ac.uk/prospero/Registration ID: CRD420251005562). Primary outcomes included SSI incidence, while secondary outcomes comprised mortality, hematoma, hospital readmission, reoperation, length of stay, and other incisional complications. Sensitivity analyses and trial sequential analyses were conducted to assess the robustness of findings.Results A total of 11 studies involving 2519 patients were included. NPWT significantly reduced the risk of surgical site infection compared to standard dressings (RR = 0.61 (95% CI: 0.44-0.86); p = 0.004). Substantial heterogeneity was present (I2 = 66%; p for heterogeneity = 0.001), which was not resolved by sensitivity analyses. No significant differences were observed in mortality (RR = 0.90 (95% CI: 0.48-1.69); p = 0.74), hematoma (RR = 0.75 (95% CI: 0.37-1.52); p = 0.42), or bleeding (RR = 0.54 (95% CI: 0.15-2.02); p = 0.36). NPWT showed no significant effects on readmission (RR = 0.65 (95% CI: 0.37-1.16); p = 0.15), reoperation (RR = 1.27 (95% CI: 0.45-3.58); p = 0.66), or length of hospital stay (MD = -0.32 (95% CI: -0.81 to 0.18); p = 0.21). Trial sequential analysis (TSA) confirmed the robustness of the primary outcome, and sensitivity analyses supported the consistency of results.Conclusions ciNPWT appears effective in reducing SSIs in abdominal surgery, yet its broader clinical value remains uncertain due to inconsistent benefits across secondary outcomes and unresolved heterogeneity. Future studies should focus on standardizing ciNPWT protocols, identifying high-risk subgroups, and evaluating cost-effectiveness, particularly in resource-limited settings.
C1 [Manasrah, AlMothana] Wilson Med Ctr, Internal Med Dept, UHS, Johnson City, NY USA.
   [Ayyad, Alaa] Al Quds Univ, Fac Med, Jerusalem, Palestine.
   [Abu Suilik, Husam] Hashemite Univ, Fac Med, Zarqa, Jordan.
   [Zibara, Zahraa] Lebanese Amer Univ, Gilbert & Rose Marie Chagoury Sch Med, Byblos, Lebanon.
   [Alalawneh, Alshayma; Al Akash, Minnat Allah; Tanashat, Mohammad] Yarmouk Univ, Fac Med, Irbid, Jordan.
   [Bataineh, Zaid] Jordan Univ Sci & Technol, Fac Med, Irbid, Jordan.
   [Rjoub, Samah] Yarmouk Univ, Fac Med, Dept Basic Pathol Sci, Irbid, Jordan.
C3 Al-Quds University; Hashemite University; Lebanese American University;
   Yarmouk University; Jordan University of Science & Technology; Yarmouk
   University
RP Zibara, Z (通讯作者)，Lebanese Amer Univ, Gilbert & Rose Marie Chagoury Sch Med, Byblos, Lebanon.
EM zahraa.zibara@lau.edu
RI ayyad, Alaa/LKO-3284-2024
OI Rjoub, Samah/0009-0000-0848-647X; Manasrah,
   AlMothana/0009-0001-6266-4991
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD JUL
PY 2026
VL 50
IS 7
BP 1862
EP 1874
DI 10.1002/wjs.70404
EA MAY 2026
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KX6GD
UT WOS:001763828900001
PM 42128818
DA 2026-07-24
ER
PT J
AU Arundel, C
   Mandefield, L
   Fairhurst, C
   Baird, K
   Saramago, P
   Gkekas, A
   Macefield, R
   Blazeby, J
   Corbacho, B
   Dixon, S
   Dumville, J
   Hatfield, J
   Hewitt, C
   Lee, M
   Mott, A
   Oswald, A
   Pinkney, T
   Stubbs, N
   Swan, S
   Torgerson, D
   Wilkinson, J
   Wilson, L
   Zahra, S
   Chetter, I
AF Arundel, Catherine
   Mandefield, Laura
   Fairhurst, Caroline
   Baird, Kalpita
   Saramago, Pedro
   Gkekas, Athanasios
   Macefield, Rhiannon
   Blazeby, Jane
   Corbacho, Belen
   Dixon, Stephen
   Dumville, Jo
   Hatfield, Josie
   Hewitt, Catherine
   Lee, Matthew
   Mott, Andrew
   Oswald, Angela
   Pinkney, Thomas
   Stubbs, Nikki
   Swan, Samantha
   Torgerson, David
   Wilkinson, Jacqueline
   Wilson, Lyn
   Zahra, Sabeen
   Chetter, Ian
CA SWHSI 2 Trial Investigators
TI Clinical and cost-effectiveness of negative pressure wound therapy
   versus usual care for surgical wounds healing by secondary intention:
   the SWHSI 2 pragmatic RCT
SO HEALTH TECHNOLOGY ASSESSMENT
LA English
DT Article
ID MULTICENTER; ULCERS; TRIAL; FOOT; DRESSINGS; ALGINATE; CLOSURE; DISEASE
AB Background: Surgical wounds healing by secondary intention occur if a surgical wound is not closed or dehisces following primary closure. Surgical wounds healing by secondary intention are common and adversely affect patients' quality of life. Treatment is often prolonged, complex and expensive. Negative pressure wound therapy applies a controlled vacuum to the wound and is increasingly used to promote surgical wound healing by secondary intention despite limited rigorous evidence for the clinical and cost-effectiveness of negative pressure wound therapy to augment surgical wound healing by secondary intention. Objective: Assess the clinical and cost-effectiveness of negative pressure wound therapy versus usual care (no negative pressure wound therapy) in treating surgical wounds healing by secondary intention. Design and methods: A pragmatic, two-arm, parallel-group, randomised controlled superiority trial. Twentyeight UK NHS Trusts randomised adult patients with a surgical wounds healing by secondary intention to receive negative pressure wound therapy or usual care (no negative pressure wound therapy). The planned sample size was 696 participants. Participants were followed up for 12 months via weekly telephone contact to collect the primary outcome (time to healing: full cover with no scab in days since randomisation) and clinical secondary outcomes: wound healing, surgical site infection, pain, hospital re-admission, current treatment and reasons for treatment change (if applicable), reoperation, amputation, antibiotic use, death. Patient-reported outcomes (pain, health-related quality of life and resource use) were collected by postal questionnaire at 3, 6 and 12 months. Validation of the Bluebelle Wound Healing Questionnaire, a patient-reported measure of surgical site infection, was also undertaken. A cost-effectiveness decision model considering all available evidence, and a within-trial cost-utility analysis, was also undertaken to evaluate the cost-effectiveness of negative pressure wound therapy against usual care. Neither participants nor the investigators were blind to treatment allocation. Results: Between 15 May 2019 and 13 January 2023, 686 participants were recruited, randomised and included in the analysis (negative pressure wound therapy n = 349; usual care n = 337). Most participants had a single surgical wound healing by secondary intention (n = 622, 90.7%), located on the foot (n = 551, 80.3%) or leg (n = 69, 10.1%) arising following vascular surgery (n = 619, 90.2%). Most participants had comorbidities; diabetes (n = 549, 80.0%), cardiovascular disease (n = 446, 65.0%) and/or peripheral vascular disease (n = 349, 50.9%). Median time to healing was 187 days (negative pressure wound therapy) versus 195 days (usual care), with no evidence that negative pressure wound therapy reduced the time to wound healing compared to usual care (hazard ratio 1.08, 95% CI 0.88 to 1.32; p = 0.47). Odds of re-admission, reoperation, surgical site infection and antibiotic use were slightly higher, and odds of amputation or death slightly lower for negative pressure wound therapy participants. These results were not clinically or statistically significant. Bluebelle Wound Healing Questionnaire, quality of life and wound pain scores were not statistically significantly different at any time point. Serious adverse events were rare (nine negative pressure wound therapy vs. five usual-care participants).
   Both cost-effectiveness analyses concluded that negative pressure wound therapy generates higher costs and marginally higher quality-adjusted life-years than usual care, although findings were statistically insignificant. The probability of negative pressure wound therapy being cost-effective was under the recommended National Institute for Health and Care Excellence cost-effectiveness thresholds. The Bluebelle Wound Healing Questionnaire was acceptable to participants, had low levels of missing data and demonstrated good levels of sensitivity and specificity in the detection of surgical site infection in surgical wounds healing by secondary intention. Limitations: The trial included a high proportion of diabetic participants with foot wounds, which may affect study generalisability. Negative pressure wound therapy use for 'wound management', common in certain surgical specialties, was not assessed in this study. Conclusions: Negative pressure wound therapy is not clinically or cost-effective in augmenting healing in patients with surgical wounds healing by secondary intention, particularly those with comorbidities. Future work: Evaluation of methods to treat or prevent infection of surgical wounds healing by secondary intention and evaluation of negative pressure wound therapy for 'wound management' are recommended. Funding: This synopsis presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number 17/42/94. A plain language summary of this synopsis is available on the NIHRJournals Library Website https://doi.org/10.3310/ GJIC1716.
C1 [Arundel, Catherine; Mandefield, Laura; Fairhurst, Caroline; Baird, Kalpita; Gkekas, Athanasios; Corbacho, Belen; Hewitt, Catherine; Mott, Andrew; Swan, Samantha; Torgerson, David; Wilkinson, Jacqueline; Zahra, Sabeen] Univ York, York Trials Unit, York, England.
   [Saramago, Pedro] Univ York, Ctr Hlth Econ, York, England.
   [Macefield, Rhiannon; Blazeby, Jane] Univ Hosp Bristol & Weston NHS Fdn Trust, Natl Inst Hlth & Care Res NIHR, Bristol Biomed Res Ctr, Bristol, England.
   [Macefield, Rhiannon; Blazeby, Jane] Univ Bristol, Bristol, England.
   [Dixon, Stephen; Hatfield, Josie; Oswald, Angela; Chetter, Ian] Hull Univ Teaching Hosp NHS Trust, Kingston Upon Hull, England.
   [Dumville, Jo] Univ Manchester, Manchester, England.
   [Lee, Matthew] Sheffield Teaching Hosp NHS Fdn Trust, Sheffield, England.
   [Pinkney, Thomas] Univ Birmingham, Inst Appl Hlth Res, Birmingham, England.
   [Stubbs, Nikki] NCS Wound Care Ltd, Leeds, England.
   [Wilson, Lyn] Mid Yorkshire Teaching NHS Trust, Wakefield, England.
   [Chetter, Ian] Hull York Med Sch, Kingston Upon Hull, England.
   [Chetter, Ian] Univ Hull, Kingston Upon Hull, England.
C3 University of York - UK; University of York - UK; University of Bristol;
   University of Manchester; University of Sheffield; University of
   Birmingham; University of Hull; University of York - UK; University of
   Hull
RP Arundel, C (通讯作者)，Univ York, York Trials Unit, York, England.
EM catherine.arundel@york.ac.uk
RI ; Blazeby, Jane/H-6703-2019; Mott, Andrew/HLQ-6922-2023; Pinkney,
   Thomas/HGA-4022-2022; Dumville, Jo/O-7867-2014; Torgerson,
   David/L-4566-2019
OI Macefield, Rhiannon/0000-0002-6606-5427; Blazeby,
   Jane/0000-0002-3354-3330; Mott, Andrew/0000-0001-7844-9033; 
FU National Institute for Health and Care Research (NIHR) Health Technology
   Assessment programme [17/42/94]; National Institutes of Health Research
   (NIHR) [17/42/94] Funding Source: National Institutes of Health Research
   (NIHR)
FX This synopsis presents independent research funded by the National
   Institute for Health and Care Research (NIHR) Health Technology
   Assessment programme as award number 17/42/94.
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NR 66
TC 0
Z9 0
U1 0
U2 0
PU NIHR JOURNALS LIBRARY
PI SOUTHAMPTON
PA UNIV SOUTHAMPTON, EVALUATION, TRIALS & STUDIES COORDINATING CENTRE,
   ALPHA HOUSE, ENTERPRISE RD, SOUTHAMPTON, SO16 7NS, ENGLAND
SN 1366-5278
EI 2046-4924
J9 HEALTH TECHNOL ASSES
JI Health Technol. Assess.
PD MAY
PY 2026
VL 30
IS 32
AR 1716
DI 10.3310/GJIC1716
PG 50
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA HV7XV
UT WOS:001763868000001
PM 42104753
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER
PT J
AU Guan, XF
   Zhu, GY
   Jiang, HW
   Wang, B
   Cheng, JX
AF Guan, Xiaofang
   Zhu, Guangyong
   Jiang, Haowei
   Wang, Bo
   Cheng, Jiaxin
TI Comparative efficacy of advanced therapeutic modalities for diabetic
   foot ulcers: a systematic review and meta-analysis including NPWT, stem
   cells, ESWT, and bioengineered treatments
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Review
DE DFU; diabetic foot ulcers; exosomes; extracorporeal shockwave therapy;
   mesenchymal stem cells; MSc; negative pressure wound therapy; Npwt
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; PLATELET-RICH PLASMA;
   CONTROLLED-TRIAL; MULTICENTER; MANAGEMENT
AB Background Diabetic foot ulcers (DFUs) are highly debilitating and often necessitate cutting-edge treatments apart from the usual care. This systematic review and meta-analysis have compared the efficacy of Negative Pressure Wound Therapy (NPWT)/VAC, cell-based therapies (MSC-based therapies), artificial skin, extracorporeal shockwave therapy (ESWT), and platelet-rich plasma (PRP) interventions in promoting healing of difficult wounds, as well as healing by other means. Methods The extensive search identified 49 randomized controlled trials. For data analysis, a random-effects model with inverse-variance weighting was used to obtain standardized mean differences (SMDs) with 95% confidence intervals (CIs). The presence of publication bias was determined using funnel plots and Egger's test, while the quality of the studies was assessed by means of Jadad scores and risk of bias tools. GRADE was employed to assess the certainty of the evidence. Results Sub-group analysis revealed that NPWT significantly accelerated wound closure compared to standard care SMD of -0.39 (95% CI: 0.57 to -0.21; I2 = 49%), indicating faster healing times, used days to measure time showed an SMD of -0.94 (95% CI: 1.07 to -0.80; I2 = 0%) which showed that patients healed at a faster rate. The comparison of different devices and techniques showed an SMD of 0.98 (95% CI: 0.75-1.21; I2 = 0%), indicating that additional treatments resulted in a greater reduction in wound area. The results were statistically significant because all p-values were lower than 0.05. MSC-based therapies showed similar overall healing (SMD = 0.46, 95% CI: 0.24-0.69) and faster closure (SMD = -1.04, 95% CI: 1.28 to -0.8). Additionally, trials of bioengineered skin substitutes, ESWT, and PRP all showed statistically significant improvements in time to wound closure and overall healing. Relative to the control group, adverse events were fewer in the NPWT and PRP groups (SMD = -0.24, 95% CI: 0.42 to -0.05). Conclusion The NPWT and MSC-based therapy, in particular, represent major improvements in healing outcomes for diabetic foot ulcers (DFUs) and in the speed of closure compared with standard treatment.
C1 [Guan, Xiaofang; Jiang, Haowei; Wang, Bo; Cheng, Jiaxin] First Peoples Hosp Xiaoshan Dist, Hand & Foot Surg, Hangzhou, Peoples R China.
   [Zhu, Guangyong] Hangzhou Hosp Zhejiang Med Hlth Grp, Dept Orthoped, Hangzhou, Peoples R China.
RP Cheng, JX (通讯作者)，First Peoples Hosp Xiaoshan Dist, Hand & Foot Surg, Hangzhou, Peoples R China.
EM chengjx_ok@126.com
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NR 54
TC 0
Z9 0
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD APR 29
PY 2026
VL 14
AR 1792670
DI 10.3389/fbioe.2026.1792670
EA APR 2026
PG 22
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA HW7FT
UT WOS:001764498500001
PM 42137620
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Duncan, AJ
   Bartholomew, R
   Hopper, WA
   Zreik, K
   Dyke, C
   Ahmeti, M
AF Duncan, Anthony J.
   Bartholomew, Reid
   Hopper, Wade A.
   Zreik, Khaled
   Dyke, Cornelius
   Ahmeti, Mentor
TI Anastomotic Outcomes After Damage Control Laparotomy With Temporary
   Abdominal Closure
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Bowel anastomosis; Negative pressure wound therapy; Open abdomen;
   Temporary abdominal closure
ID COLONIC INJURIES; OPEN ABDOMEN; TRAUMA; COMPLICATIONS; MANAGEMENT
AB Introduction: Negative pressure wound therapy (NPWT) is widely utilized to facilitate temporary abdominal closure following damage control laparotomy. The direct role of NPWT on anastomotic leak rates remains unclear. This study evaluates whether anastomotic exposure to NPWT is associated with increased risk for leak. Materials and methods: We performed a retrospective cohort study including all patients who underwent emergent exploratory laparotomy with temporary abdominal closure at our institution from 2013 to 2023. Patients were stratified based on whether or not they were treated with intra-abdominal NPWT applied in the setting of a newly created anastomosis. Results: Of 225 included patients, 93 (41%) received anastomotic exposure to NPWT. In multivariable regression, anastomotic NPWT exposure was not significantly associated with risk of leak. However, the Physiological Emergency Surgery Acuity Score (odds ratio: 1.359, P= 0.010) and days to fascial closure (odds ratio: 1.274, P< 0.001) were independent predictors of anastomotic leak. Conclusions: In patients undergoing damage control laparotomy, anastomotic NPWT exposure is not a clear independent risk factor for anastomotic leak and may be judiciously applied to bowel anastomoses when clinically indicated. The risk for leak appears to be more strongly associated with physiologic acuity and illness severity.<br /> (c) 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Duncan, Anthony J.; Bartholomew, Reid; Hopper, Wade A.; Zreik, Khaled; Dyke, Cornelius; Ahmeti, Mentor] Univ North Dakota, Sch Med & Hlth Sci, Dept Surg, Fargo, ND USA.
   [Zreik, Khaled; Dyke, Cornelius; Ahmeti, Mentor] Sanford Med Ctr Fargo, Dept Trauma & Acute Care Surg, Fargo, ND USA.
   [Duncan, Anthony J.] Univ North Dakota, Sch Med & Hlth Sci, Dept Surg, 1919 North Elm, Fargo, ND 58102 USA.
C3 University of North Dakota Grand Forks; Sanford Health; University of
   North Dakota Grand Forks
RP Duncan, AJ (通讯作者)，Univ North Dakota, Sch Med & Hlth Sci, Dept Surg, 1919 North Elm, Fargo, ND 58102 USA.
EM Anthony.duncan@und.edu
RI duncan, anthony/JTU-1888-2023
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   Coccolini F, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0026-5
   Garnica DGG, 2024, J SURG RES, V296, P223, DOI 10.1016/j.jss.2024.01.003
   George MJ, 2018, AM J SURG, V216, P56, DOI 10.1016/j.amjsurg.2017.10.044
   Georgoff P, 2013, J SURG RES, V181, P293, DOI 10.1016/j.jss.2012.07.011
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Harvin JA, 2016, AM J SURG, V212, P34, DOI 10.1016/j.amjsurg.2015.10.014
   Jozwiak M, 2022, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.826446
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD JUL
PY 2026
VL 323
BP 71
EP 76
DI 10.1016/j.jss.2026.04.001
EA MAY 2026
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HW8GN
UT WOS:001764568100001
PM 42092274
DA 2026-07-24
ER
PT J
AU Hua, RY
   Gan, ZL
   Zhong, J
   Xian, JL
   Liang, YQ
   Deng, SP
   Zhu, CH
   Jiang, XL
AF Hua, Ruoyue
   Gan, Zilin
   Zhong, Jun
   Xian, Jianlin
   Liang, Yaoqi
   Deng, Shoupeng
   Zhu, Chonghao
   Jiang, Xiaolong
TI Non-clostridial gas gangrene involving the thyroid gland complicated by
   multiple infections in a diabetic patient: a case report
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Gas gangrene; thyroid gland; Escherichia coli; thyroidectomy; case
   report
AB The thyroid gland is usually resistant to infection due to its nature, including rich blood supply and lymphatic drainage. Gas gangrene involving the thyroid is extremely rare and may be related to preexisting thyroid disease or diabetes. Few related cases have been reported, among which non-clostridial gas gangrene (NCGG) is particularly uncommon. Here, we briefly describe the diagnosis and treatment of a rare NCGG case involving the right lobe of the thyroid gland. A 60-year-old female patient presented with neck pain accompanied by discomfort during eating, which acutely worsened with sudden neck swelling one day before admission. Laboratory examination revealed fever, significantly elevated blood glucose, restricted neck movement, increased local skin temperature, and palpable crepitus in the cervical region. Based on clinical assessment, the patient was diagnosed with acute suppurative thyroiditis complicated by gas gangrene and poorly controlled diabetes. Intraoperative findings and post-operative histopathologic examination supported the diagnosis of NCGG. A right thyroid lobectomy was performed, along with resection of the isthmus and the left inferior thyroid pole, followed by vacuum sealing drainage with polyurethane. The patient recovered well, with no evidence of recurrence or complications at the 4-month follow-up. Successful management of this condition requires early debridement, resection of necrotic tissue, appropriate drainage, and close monitoring for potential airway complications, such as tracheomalacia.
C1 [Hua, Ruoyue; Gan, Zilin; Zhong, Jun; Xian, Jianlin; Liang, Yaoqi; Deng, Shoupeng; Zhu, Chonghao; Jiang, Xiaolong] Wuzhou Gongren Hosp, Dept Wound Repair, Wuzhou 543000, Guangxi, Peoples R China.
RP Hua, RY (通讯作者)，Wuzhou Gongren Hosp, Dept Wound Repair, Wuzhou 543000, Guangxi, Peoples R China.
EM feelgood2000@163.com
CR ALWAKEEL J, 1995, ANN SAUDI MED, V15, P71, DOI 10.5144/0256-4947.1995.71
   Branca JJV, 2022, MEDICINA-LITHUANIA, V58, DOI 10.3390/medicina58010137
   Buboltz JB, 2026, TREASURE ISLAND FL I
   Ishida K, 2016, ACUTE MED SURG, V3, P128, DOI 10.1002/ams2.135
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NR 10
TC 0
Z9 0
U1 1
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2026
VL 18
IS 4
BP 3403
EP 3407
DI 10.62347/JHCU2388
PG 5
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA HW8UT
UT WOS:001764605100006
PM 42170444
OA Green Submitted
DA 2026-07-24
ER
PT J
AU Xiao, WH
   Ming, XC
   Huang, YX
   Li, JX
   Jiao, QQ
   Yang, J
   Zheng, LY
   Zeng, YF
   Wang, R
   Cheng, SW
   Bian, YY
   Yao, JL
AF Xiao, Weihao
   Ming, Xingchen
   Huang, Yuxi
   Li, Jiaxuan
   Jiao, Qiqi
   Yang, Jian
   Zheng, Linyang
   Zeng, Yunfu
   Wang, Rong
   Cheng, Shaowen
   Bian, Yangyang
   Yao, Jiangling
TI A retrospective analysis of the surgical efficacy for tophi wounds in
   Hainan province
SO FRONTIERS IN SURGERY
LA English
DT Article
DE gout; retrospective studies; surgical procedures; operative; tophi;
   treatment outcome; uric acid
ID CLINICAL CHARACTERISTICS; GOUT; MANAGEMENT
AB Introduction: Gouty tophi are chronic inflammatory nodules resulting from monosodium urate (MSU) crystal deposition, often leading to joint deformity, skin ulceration, and functional impairment. Surgical management remains controversial due to a lack of standardized indications. This study aimed to evaluate the efficacy of surgical treatment for gouty tophi wounds and to explore surgical indications. Methods: This retrospective study consecutively enrolled patients with gouty tophi wounds who underwent surgical treatment at the First Affiliated Hospital of Hainan Medical University, a tertiary hospital in Haikou, Hainan Province, China, between April 2018 and April 2024. Clinical data, including demographic characteristics, infection markers, nutritional parameters, and surgical outcomes, were collected from electronic medical records and paper-based patient charts. Perioperative changes in these indicators were analyzed. The study was reported in accordance with the STROBE guidelines. Results: A total of 130 patients were included, comprising 129 males (99.2%) and 1 female (0.8%), with a mean age of 58.15 +/- 14.04 years. The primary comorbidities included hypertension (43.85%), diabetes mellitus (13.85%), renal insufficiency (11.54%), and hyperlipidemia (8.46%). The primary surgical modalities were lesion excision (41.54%), debridement (34.62%), and vacuum sealing drainage (VSD) (23.08%). Wound healing was achieved in 124 cases (95.38%), with a mean healing time of 31.43 +/- 16.18 days; 5 cases (3.85%) failed to heal, and 1 patient (0.77%) died from multiorgan failure. The positive microbiological culture rate decreased from 21 cases (16.15%) preoperatively to 1 case (0.77%) postoperatively, with Staphylococcus aureus (28.57%) being the predominant preoperative pathogen. Postoperative laboratory parameters showed significant reductions in white blood cell count (WBC, P < 0.05), neutrophil count (NE, P < 0.001), blood urea nitrogen (BUN, P < 0.001), uric acid (P < 0.001), and creatinine (P < 0.001) compared with preoperative values. Albumin levels increased slightly (P > 0.05), while prealbumin levels rose significantly (P < 0.001). Pain scores assessed by the Faces Pain Scale-Revised (FPS-R, P < 0.001) and the Changhai Pain Scale (P < 0.001) also demonstrated marked postoperative declines. Discussion: Surgical management of gouty tophi wounds is associated with favorable wound healing, significant systemic anti-inflammatory and metabolic benefits, and effective pain relief. The low infection rate in ulcerated tophi supports the bacteriostatic role of MSU crystals. Based on these findings, surgical indications include functional impairment, chronic non-healing wounds, refractory pain, and large tophi (>1.5 cm) impeding daily activities. Surgery should be avoided during acute gout flares and in high-risk patients with uncontrolled comorbidities.
C1 [Xiao, Weihao; Ming, Xingchen; Huang, Yuxi; Li, Jiaxuan; Jiao, Qiqi; Yang, Jian; Zheng, Linyang; Zeng, Yunfu; Wang, Rong; Cheng, Shaowen; Bian, Yangyang; Yao, Jiangling] Hainan Med Univ, Dept Wound Repair ,Affiliated Hosp 1, Key Lab Emergency & Trauma,Minist Educ, Key Lab Hainan Trauma & Disaster Rescue, Haikou, Peoples R China.
C3 Hainan Medical University
RP Yao, JL (通讯作者)，Hainan Med Univ, Dept Wound Repair ,Affiliated Hosp 1, Key Lab Emergency & Trauma,Minist Educ, Key Lab Hainan Trauma & Disaster Rescue, Haikou, Peoples R China.
EM yaojiangling917@126.com
FU Hainan Provincial Natural Science Foundation of China [822QN463]; Joint
   Program on Health Science & Technology Innovation of Hainan Province
   [WSJK2025QN076, WSJK2024QN013]; National Natural Science Foundation of
   China [82260373]; Hainan Medical College 2024 Student Innovation and
   Entrepreneurship Training Program [S202511810040,X202411810135]
FX The author(s) declared that financial support was received for this work
   and/or its publication. This work was supported by the Hainan Provincial
   Natural Science Foundation of China (822QN463), and Joint Program on
   Health Science & Technology Innovation of Hainan Province
   (WSJK2025QN076, WSJK2024QN013), National Natural Science Foundation of
   China (82260373), Hainan Medical College 2024 Student Innovation and
   Entrepreneurship Training Program (S202511810040,X202411810135).
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NR 31
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD APR 30
PY 2026
VL 13
AR 1752070
DI 10.3389/fsurg.2026.1752070
EA APR 2026
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HY1XX
UT WOS:001765495200001
PM 42147384
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU da Rocha, CC
   Filizzola, RL
   Sorrenti, L
   Cho, AB
   Ferreira, CHV
   Kiyohara, LY
   de Souza, ERA
   da Silva, CR
AF da Rocha, Cleyton Chaves
   Filizzola, Ricardo Lavorato
   Sorrenti, Luiz
   Cho, Alvaro Baik
   Ferreira, Carlos Henrique Vieira
   Kiyohara, Leandro Yoshinobu
   de Souza, Eduardo Romera Alves
   da Silva, Carina Rocha
TI NEGATIVE PRESSURE WOUND THERAPY AS AN ADJUNCT TO SKIN GRAFTING IN
   TRAUMATIC INJURIES TERAPIA POR PRESSÃO NEGATIVA COMO ADJUVANTE AOS
   ENXERTOS DE PELE EM LESÕES TRAUMÁTIC AS
SO ACTA ORTOPEDICA BRASILEIRA
LA English
DT Article
DE Skin Transplantation; Patient Isolators; Low Cost Tech-nology; Wounds
   and Injuries
AB Introduction: Wounds are a challenge for health professionals and services, prolonging hospital stays and increasing morbidity and mortality rates. Wounds occur due to post-traumatic tissue loss, which is often difficult to resolve and is complicated by infections, local vascular impairment, and systemic diseases. To demonstrate the effectiveness of negative pressure therapy (NPT) using the vacuum gauge of the hospital gas pipeline and low-cost materials in the immediate postoperative period. To use resources available in daily hospital practice to create a low-cost vacuum dressing. To describe the equipment, preparation, and technique involved in low-cost NPT treatment as an adjuvant in the repair of lesions with indication for skin grafting. Methodology: Prospective, interventional, randomized clinical study with a non-inferiority design. Results: Fifteen patients were included at the end of the study, with complete follow-up until complete healing. The mean age of the selected patients was 38.27 years. Regarding gender, 93.3% were male and 6.7% were female. Conclusion: Thus, the results suggested that the use of low-cost NPT on skin grafts is a valuable, safe, easily reproducible and low-morbidity tool for surgeons technical arsenal. Level of Evidence: IV; Case Series.
C1 [da Rocha, Cleyton Chaves; Filizzola, Ricardo Lavorato; Sorrenti, Luiz; Cho, Alvaro Baik; Ferreira, Carlos Henrique Vieira; Kiyohara, Leandro Yoshinobu; de Souza, Eduardo Romera Alves; da Silva, Carina Rocha] Hosp Estadual Mario Covas, Fac Med ABC, Grp Cirurgia Mao & Microcirurgia, Sao Paulo, SP, Brazil.
C3 Faculdade de Medicina do ABC
RP da Rocha, CC (通讯作者)，Cond Mini Chacaras Lago Sul, Quadra 06 Conjunto 03,Casa 32, BR-71680621 Brasilia, DF, Brazil.
EM cleyton.rocha@yahoo.com.br
RI /AAR-8652-2021
OI Romera Alves de Souza, Eduardo/0000-0001-8414-2150
CR Alves L. M., 2009, Revista de Ciencias Medicas, V18, P201
   Brasil. Ministerio da Saude, 2023, B EPIDEMIOLOGICO ACI
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   2024, Journal of Wound Management Official journal of the European Wound Management Association, DOI [10.35279/jowm2024.25.02.sup01, 10.35279/jowm2024.25.02.sup01, DOI 10.35279/JOWM2024.25.02.SUP01]
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   Webster J, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub3
NR 13
TC 0
Z9 0
U1 0
U2 0
PU ATHA COMUNICACAO & EDITORA
PI SAO PAULO
PA RUA MACHADO BITTENCOURT, 190-40 ANDAR, CONJ 410, SAO PAULO, Sao Paulo,
   BRAZIL
SN 1413-7852
EI 1809-4406
J9 ACTA ORTOP BRAS
JI Acta Ortop. Bras.
PY 2026
VL 34
IS 1
AR e292923
DI 10.1590/1413-785220263401e292923
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HY5VP
UT WOS:001765760100004
PM 41924016
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Hayashi, D
   Kojima, K
   Tokunaga, T
   Okishio, K
   Yoon, H
AF Hayashi, Daiki
   Kojima, Kensuke
   Tokunaga, Toshiteru
   Okishio, Kyoichi
   Yoon, Hyungeun
TI Single-stage open window thoracostomy with simultaneous muscle flap
   transposition and early negative pressure wound therapy for chronic
   empyema: a propensity score- and machine learning-based study
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Bronchopleural fistula; Chronic empyema; Muscle flap transposition;
   Negative pressure wound therapy; Open window thoracostomy
ID MANAGEMENT
AB Background To compare the clinical efficacy of a single-stage surgical approach combining open window thoracostomy, muscle flap transposition, and early negative pressure wound therapy (NPWT) with that of conventional staged management for chronic empyema. Methods This retrospective, single-center cohort included 45 patients with chronic empyema (single-stage, n = 7; conventional, n = 38) who were treated from 2009 to 2024. The primary endpoint was the cavity reduction ratio measured via three-dimensional computed tomography (3D CT). To minimize selection bias, we applied propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). We prespecified the average treatment effect on the treated (ATT) as the primary estimand, whereas the average treatment effect (ATE) was considered exploratory because treatment assignment was strongly related to bronchopleural fistula (all single-stage patients had BPF) and overlap was limited. The follow-up intervals were linearly normalized to adjust for time-dependent variability. Machine learning models were used as complementary predictive analyses to identify predictors of cavity reduction. Results After PSM (n = 5 per group), the single-stage group had significantly greater cavity reduction than the conventional group did (90% [89-94%] vs. 37% [32-43%], p = 0.008). The IPTW analysis demonstrated significant treatment effects: 0.38 (95% CI: 0.17-0.59, p = 0.005) for the ATT and 0.63 (95% CI: 0.12-1.14, p = 0.03) for the ATE (exploratory). Machine learning models consistently identified the treatment approach and time-related variables as important predictors of cavity reduction. Conclusions Compared with conventional management, the single-stage approach was associated with significantly greater empyema cavity reduction and was feasible even in patients with bronchopleural fistulas. Causal interpretation is most defensible for the ATT, whereas generalization to the full population (ATE) should be considered exploratory due to limited overlap. Despite the small sample size, the consistent findings across diverse analytical frameworks support the single-stage strategy as a promising approach that warrants prospective multicenter validation and clearer criteria for patient selection.
C1 [Hayashi, Daiki; Kojima, Kensuke; Tokunaga, Toshiteru; Yoon, Hyungeun] NHO Kinki Chuo Chest Med Ctr, Dept Gen Thorac Surg, 1180 Nagasone Cho,Kita Ku, Sakai, Osaka 5918555, Japan.
   [Okishio, Kyoichi] Clin Res Ctr, NHO Kinki Chuo Chest Med Ctr, Osaka, Japan.
   [Okishio, Kyoichi] NHO Kinki Chuo Chest Med Ctr, Dept Thorac Oncol, Osaka, Japan.
RP Kojima, K (通讯作者)，NHO Kinki Chuo Chest Med Ctr, Dept Gen Thorac Surg, 1180 Nagasone Cho,Kita Ku, Sakai, Osaka 5918555, Japan.
EM k7kensuke@icloud.com
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   Zhao MY, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01070-3
   Zhu PF, 2022, INTERACT CARDIOV TH, V34, P760, DOI 10.1093/icvts/ivac011
NR 23
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD APR 3
PY 2026
VL 21
IS 1
AR 235
DI 10.1186/s13019-026-03997-y
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA IA1FC
UT WOS:001766798800010
PM 41933357
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Bauerle, W
   Evans, J
   Lee, R
   Worobetz, N
   Reese, V
   Sanders, C
AF Bauerle, Wayne
   Evans, Joseph
   Lee, Ryan
   Worobetz, Nestor
   Reese, Vanessa
   Sanders, Christopher
TI Negative Pressure Therapy Postabdominal Body Contouring in Bariatric
   Surgery Patients
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE abdominoplasty; massive weight loss; abdominal body contouring; body
   contouring; negative pressure; negative pressure wound dressing;
   incisional dressing; PICO; Prevena; bariatric surgery
ID MASSIVE WEIGHT-LOSS; SURGICAL-SITE INFECTIONS; WOUND THERAPY;
   COMPLICATIONS; MANAGEMENT
AB Background: The primary aim of this study was to investigate the effects of Incisional Negative Pressure Wound Therapy (iNPWT) on surgical site complication rates for abdominal body contouring following bariatric surgery that resulted in massive weight loss. Methods: A large 15-hospital retrospective case-control study was conducted. Inclusion criteria consisted of nonsmokers who achieved massive weight loss, defined as > 100 lb or > 50% excess body weight, and had an abdominal body contouring surgery between January 2021 and June 2024. We conducted separate unadjusted analyses comparing the iNPWT cohort to the control cohort using separate chi-square or Fisher exact tests for categorical variables, and independent samples t tests or Mann-Whitney rank sums tests for normally distributed and skewed continuous variables, respectively. Statistical significance was set to P = 0.05. Results: Basic demographics were similar for a majority of the variables between the iNPWT cohort and the standard cohort. Minor wound complications following abdominal body contouring surgery did not significantly differ between the standard and iNPWT (40.54% vs 36.36%, P = 0.070) cohorts. However, among major wound complications, rates of wound dehiscence (22.97% vs 2.27%, P = 0.003) and infection (21.62% vs 6.82%, P = 0.040) were significantly lower in the iNPWT cohort. There was no significant difference in hematoma or seroma formation between the 2 groups. Conclusion: Given the high volume of patients undergoing abdominal body contouring surgery following bariatric surgery, iNPWT dressings can provide plastic surgeons with an adjunct to further reduce the incidence of wound dehiscence and wound infection.
C1 [Bauerle, Wayne; Evans, Joseph; Worobetz, Nestor] St Lukes Univ Hlth Network, Dept Surg, 801 Ostrum St, Bethlehem, PA 18015 USA.
   [Lee, Ryan] Temple St Lukes Sch Med, Bethlehem, PA USA.
   [Reese, Vanessa] St Lukes Univ Hlth Network, Dept Res & Innovat, Bethlehem, PA USA.
   [Sanders, Christopher] St Lukes Univ Hlth Network, Dept Plast & Reconstruct Surg, Bethlehem, PA USA.
RP Bauerle, W (通讯作者)，St Lukes Univ Hlth Network, Dept Surg, 801 Ostrum St, Bethlehem, PA 18015 USA.
EM wbauerle1@gmail.com; joseph.evans@sluhn.org; rlee1682@gmail.com;
   nestor.worobetz@sluhn.org; vanessa.reese@sluhn.org;
   christopher.sanders@sluhn.org
CR Abesamis GM, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002141
   Altieri MS, 2017, OBES SURG, V27, P2981, DOI 10.1007/s11695-017-2732-4
   Baghaki S., 2017, TIRYAKI K EDS INVERS, DOI [org/10.1007/978-3-319-39310-0_10, DOI 10.1007/978-3-319-39310-0_10]
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2026
VL 96
SU 5
BP S353
EP S358
DI 10.1097/SAP.0000000000004617
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IA3GV
UT WOS:001766939500018
PM 41587358
DA 2026-07-24
ER
PT J
AU Wang, WH
   Lou, YF
   Yang, LF
   Zhou, P
AF Wang, Wenhua
   Lou, Yang Feng
   Yang, Long Fei
   Zhou, Peng
TI Salvage of preputial flap necrosis in penile glans melanosis using
   Integra dermal regeneration template and split-thickness skin graft: A
   case report
SO MEDICINE
LA English
DT Article
DE dermal regeneration template; flap necrosis; Integra; negative-pressure
   wound therapy; penile glans melanosis; preputial flap; psychosexual
   outcome; split-thickness skin graft
AB Rationale: Penile glans melanosis is a benign but psychologically distressing condition. While surgical excision with flap reconstruction is a standard treatment for extensive lesions, total flap necrosis presents a significant reconstructive challenge. This report describes a successful salvage strategy using a dermal regeneration template (Integra) and split-thickness skin grafting (STSG) after the failure of a primary preputial flap. Patient concerns: A 24-year-old male with a 2.0 & times; 1.5 cm benign melanosis of the glans penis underwent complete excision and reconstruction with a pedicled inner preputial flap. However, at the 3-week follow-up, the patient presented with complete flap necrosis, necessitating further intervention. Diagnoses: Postoperative complete necrosis of the pedicled inner preputial flap following excision of glans melanosis. Interventions: Following thorough debridement of the necrotic tissue, a staged salvage procedure was initiated. First, a single-layer Integra Dermal Regeneration Template was applied to the wound bed and managed with continuous negative-pressure wound therapy at -125 mm Hg for 3 weeks to promote neodermis formation. Subsequently, a 0.3-mm meshed STSG harvested from the right thigh was transplanted onto the matured neodermis and secured with negative-pressure wound therapy for 5 days. Outcomes: Complete epithelialization was achieved 6 months postoperatively, resulting in a smooth contour and minimal scarring. At the 24-month follow-up, the patient reported preserved erogenous sensation (2-point discrimination of 5 mm) and improved psychosexual satisfaction, with IIEF-15 scores increasing from 5/10 to 8/10. No recurrence or contracture was observed. Lessons: Staged reconstruction using a dermal regeneration template followed by STSG is a reliable and effective salvage technique for flap failure in glans surgery. This approach avoids the complications of secondary flap harvesting while ensuring excellent functional, sensory, and cosmetic outcomes, making it a valuable tool for complex penile surface reconstruction.
C1 [Lou, Yang Feng] Hangzhou Third Peoples Hosp, Dept Gen Surg, Hangzhou, Peoples R China.
   [Yang, Long Fei; Zhou, Peng] Hangzhou Third Peoples Hosp, Dept Urol, Hangzhou 310009, Zhejiang, Peoples R China.
RP Zhou, P (通讯作者)，Hangzhou Third Peoples Hosp, Dept Urol, Hangzhou 310009, Zhejiang, Peoples R China.
EM 1295744809@qq.com; cwgebao@126.com; 250810584@qq.com;
   13616555138@139.com
CR Alnajjar HM, 2020, CURR OPIN UROL, V30, P213, DOI 10.1097/MOU.0000000000000711
   DELANEY TA, 1994, BRIT J DERMATOL, V130, P663, DOI 10.1111/j.1365-2133.1994.tb13117.x
   Falcone M, 2022, UROLOGY, V165, P250, DOI 10.1016/j.urology.2022.01.010
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   Gonzalez SR, 2020, PRS-GLOB OPEN, V8, DOI 10.1097/GOX.0000000000002869
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NR 11
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY 15
PY 2026
VL 105
IS 20
AR e48843
DI 10.1097/MD.0000000000048843
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IA8XH
UT WOS:001767323200032
PM 42152403
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Juengsirakulwit, K
   Amornfa, J
AF Juengsirakulwit, Kusawadee
   Amornfa, Jiraphorn
TI Effectiveness of closed incisional negative pressure wound therapy in
   pediatric spinal dysraphism: a single-center retrospective case series
SO CHILDS NERVOUS SYSTEM
LA English
DT Article
DE Spinal dysraphism; Closed incisional negative pressure wound therapy;
   ciNPWT; Myelomeningocele; Pediatric neurosurgery; Postoperative wound
   complication; Surgical site infection; CSF leakage
ID CORD LIPOMAS
AB Introduction Postoperative wound complications - including surgical site infection (SSI), cerebrospinal fluid (CSF) leakage, and wound dehiscence - remain a significant challenge following surgery for spinal dysraphism, particularly in neonates and infants. Closed incisional negative pressure wound therapy (ciNPWT) has demonstrated benefit in several surgical sub-specialties; however, evidence regarding its routine use in pediatric spinal dysraphism surgery is limited. MethodsA retrospective review was conducted of all pediatric patients (age < 18 years) who underwent surgery for spinal dysraphism and received ciNPWT as part of postoperative wound management at King Chulalongkorn Memorial Hospital between June 2020 and March 2024. Primary outcomes included postoperative wound complications (SSI, CSF leakage, wound dehiscence, and wound necrosis) within 30 days of surgery. The number of postoperative dressing changes was recorded as a secondary outcome and surrogate marker of wound care burden. Results A total of 28 patients were included: 8 with open spinal dysraphism (myelomeningocele, myeloschisis, or hem-imyelomeningocele) and 20 with closed spinal dysraphism or related conditions (including 2 pygopagus conjoined twins). The median number of dressing changes was 3 (range 3-5) for open dysraphism and 2 (range 1-2) for closed dysraphism. Primary wound closure was achieved in all cases. No postoperative wound complications - including SSI, CSF leakage, wound dehiscence, or wound necrosis - were observed during the follow-up period. Conclusion Closed incisional negative pressure wound therapy appears to be a safe and effective adjunct for postoperative wound management in pediatric spinal dysraphism surgery, demonstrating favorable wound outcomes across both open and closed dysraphism types, including complex high-risk cases.
C1 [Juengsirakulwit, Kusawadee; Amornfa, Jiraphorn] King Chulalongkorn Mem Hosp, Dept Surg, Neurosurg Unit, Thai Red Cross Soc, Bangkok, Thailand.
C3 Thai Red Cross Society; Chulalongkorn University
RP Juengsirakulwit, K (通讯作者)，King Chulalongkorn Mem Hosp, Dept Surg, Neurosurg Unit, Thai Red Cross Soc, Bangkok, Thailand.
EM Kusawadee.J@chulahospital.org
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NR 10
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0256-7040
EI 1433-0350
J9 CHILD NERV SYST
JI Childs Nerv. Syst.
PD MAY 16
PY 2026
VL 42
IS 1
AR 222
DI 10.1007/s00381-026-07318-5
EA MAY 2026
PG 7
WC Clinical Neurology; Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pediatrics; Surgery
GA IB1EF
UT WOS:001767477800001
PM 42141294
DA 2026-07-24
ER
PT J
AU Gao, M
   Zhang, XX
   Jian, TZ
   Sun, CC
   Yu, GC
   Gao, YK
   Kan, BT
   Jian, XD
AF Gao, Ming
   Zhang, Xiangxing
   Jian, Tianzi
   Sun, Cece
   Yu, Guangcai
   Gao, Yikai
   Kan, Baotian
   Jian, Xiangdong
TI Medical management of a child treated for two unique envenomation
   episodes via captive snakes in a 60-day period: A case report
SO HELIYON
LA English
DT Article
DE Snake bite; Bungarus multicinctus; Gloydius brevicaudus; Antivenom;
   Necrosis
ID ANTIVENOM; BITES
AB Venomous snake bites can result in irreversible damage, leading to respiratory dysfunction, bleeding disorders, kidney damage, or serious complications. In recent years, with the popularity of online shopping in China, snakes can be easily purchased and kept as pets, even if some areas are not natural habitats for certain kinds of snakes. A 13-year-old boy purchased two venomous snakes online as pets. On April 16, 2019,the boy was bitten by a B. multicinctus(Bungarus multicinctus), and he had mild difficulty breathing and limb weakness. He was discharged after symptomatic treatment with B. multicinctus antivenom. On June 17, 2019, the boy was bitten a second time by a short-tailed pit viper (Gloydius brevicaudus) resulting in swelling and necrosis of the left hand. After a systemic and comprehensive treatment was implemented, including Agkistrodon halys antivenom injections, infection control, hormone therapy, improved circulation, negative pressure wound therapy, skin graft, and nutritional support, the boy recovered. This case provides valuable insights for diagnosing and treating venomous snake bites and their complications while also raising public awareness about the hazards of purchasing venomous snakes online,and it also provide case support for the improvement of online shopping for minors, wildlife protection, and live animal mailing management, helping to prevent such incidents from happening again.
C1 [Gao, Ming; Sun, Cece; Yu, Guangcai; Gao, Yikai; Jian, Xiangdong] Shandong Univ, Cheeloo Coll Med, Dept Poisoning & Occupat Dis Emergency Med, Qilu Hosp, Jinan 250012, Shandong, Peoples R China.
   [Gao, Ming] Peking Univ Third Hosp, Dept Emergency Med, Beijing, Peoples R China.
   [Zhang, Xiangxing; Jian, Xiangdong] Shandong Univ, Cheeloo Coll Med, Sch Publ Hlth, Dept Occupat & Environm Hlth, Jinan 250012, Shandong, Peoples R China.
   [Jian, Tianzi] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Hematol, Jinan 250012, Shandong, Peoples R China.
   [Kan, Baotian] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Nursing, Jinan 250012, Shandong, Peoples R China.
   [Jian, Xiangdong] Shandong Univ, Dept Poisoning & Occupat Dis, Emergency Med, Qilu Hosp, 107 Rd Wenhuaxi, Jinan 250012, Shandong, Peoples R China.
   [Kan, Baotian] Shandong Univ, Qilu Hosp, Dept Geriatr Med, Cheeloo Coll Med, 107 Rd Wenhuaxi, Jinan 250012, Shandong, Peoples R China.
C3 Shandong University; Shandong University; Shandong University; Shandong
   University; Shandong University; Shandong University
RP Jian, XD (通讯作者)，Shandong Univ, Dept Poisoning & Occupat Dis, Emergency Med, Qilu Hosp, 107 Rd Wenhuaxi, Jinan 250012, Shandong, Peoples R China.; Kan, BT (通讯作者)，Shandong Univ, Qilu Hosp, Dept Geriatr Med, Cheeloo Coll Med, 107 Rd Wenhuaxi, Jinan 250012, Shandong, Peoples R China.
EM kanbaotian@163.com; jianxiangdongvip@vip163.com
RI Jian, Tianzi/KIB-4716-2024; Yu, Guangcai/KIJ-5983-2024
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NR 27
TC 1
Z9 1
U1 0
U2 0
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV 30
PY 2024
VL 10
IS 22
AR e40245
DI 10.1016/j.heliyon.2024.e40245
EA NOV 2024
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IB7JD
UT WOS:001767896800001
PM 39748992
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lakha, AS
   Neves, S
   Alemour, Y
   McGivern, H
   Gordon-Weeks, A
AF Lakha, Adil S.
   Neves, Salma
   Alemour, Younis
   McGivern, Hannah
   Gordon-Weeks, Alex
TI Negative-pressure wound therapy in thoracic and abdominal surgery:
   meta-analysis of randomized trials
SO BJS OPEN
LA English
DT Review
ID SURGICAL-SITE INFECTION; HIGH-RISK; CESAREAN DELIVERY; FINANCIAL IMPACT;
   OBESE WOMEN; COMPLICATIONS; LAPAROTOMY; PREVENTION; INCISIONS
AB Background Around 30 000 patients undergo emergency laparotomy in the UK each year, and a similar number of patients undergo open cardiothoracic surgery. Surgical site infection is a common complication associated with increased morbidity, prolonged hospital stay, and higher healthcare costs. Negative-pressure wound therapy has been proposed as a prophylactic strategy to reduce wound complications, but trial evidence has been inconsistent.Methods This systematic review and meta-analysis was carried out using PRISMA guidelines and was registered prospectively in PROSPERO (CRD420251010516). A literature search was carried out in March 2025 (updated December 2025), and titles and abstracts were screened against predefined inclusion criteria. Trials assessing patients undergoing open thoracic or abdominal surgery for any indication in adult patients assessing the risk of surgical site infection as an outcome were included. Quality assessment was performed using Cochrane's risk-of-bias 2 tool. Summary statistics for outcomes of interest underwent meta-analyses to a confidence interval of 95% and are presented as forest plots.Results Some 12 427 patients across 45 randomized trials in abdominal and thoracic surgery were included for analysis. Negative-pressure wound therapy significantly reduced surgical site infection compared with standard dressings (odds ratio (OR) 0.53, 95% confidence interval 0.42 to 0.66). The effect was consistent across commercial devices (PICO (TM) and Prevena (TM)). Negative-pressure wound therapy was associated with shorter hospital stay (mean difference -1.67 (95% confidence interval -3.19 to -0.16) days), but not with reduced risk of organ/space infection (OR 0.92, 0.67 to 1.25), wound dehiscence, or reoperation. Only three studies included thoracic surgery and no significant difference in surgical site infection was found (OR 0.44, 0.00 to 45.25). Publication bias was detected; trim-and-fill analysis attenuated but did not eliminate the benefit (adjusted OR 0.70, 0.54 to 0.90). Adverse events and patient-reported outcomes were reported infrequently, and showed no consistent differences.Conclusion Negative-pressure wound therapy was associated with a nearly 50% reduction in SSI and shorter hospital stay after open abdominal surgery, with consistent benefit across device types. However, evidence of publication bias, and limited long-term and patient-reported outcome data suggest that effect size may be overestimated. Selective use in high-risk patients is supported.
   This systematic review and meta-analysis of 45 randomized trials including over 12 000 patients found that closed-incision negative-pressure wound therapy (NPWT) significantly reduces surgical site infections (SSIs) and shortens hospital stay following open abdominal surgery, with consistent effects across device types. No benefit was observed for organ/space infection, fascial dehiscence or reoperation, and evidence of publication bias suggests that, although the magnitude of benefit may be overestimated, the reduction in SSI remains statistically significant when adjusted for this. These findings support selective use of NPWT in high-risk patients, while underscoring the need for cost-effectiveness analyses and long-term outcome data.
C1 [Lakha, Adil S.; Gordon-Weeks, Alex] Univ Oxford, Nuffield Dept Surg Sci, Oxford, England.
   [Lakha, Adil S.; Gordon-Weeks, Alex] Oxford Univ Hosp NHS Fdn Trust, Dept Hepatobiliary & Pancreat Surg, Oxford, England.
   [Neves, Salma] Thames Valley Fdn Sch, Oxford, England.
   [Alemour, Younis] Univ Oxford, Bodleian Healthcare Lib, Oxford, England.
   [McGivern, Hannah] Sorbonne Univ, Dept Integrat Biol, Paris, France.
C3 University of Oxford; Oxford University Hospitals NHS Foundation Trust;
   University of Oxford; Sorbonne Universite
RP Lakha, AS (通讯作者)，Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Headley Way, Oxford OX3 9DU, England.
EM asl48@cantab.ac.uk
RI Lakha, Adil/LZI-2877-2025
FU National Institute for Health Research (NIHR)
FX A.S.L. is supported by a National Institute for Health Research (NIHR)
   Academic Clinical Fellowship (2024-27). The views expressed are those of
   the author(s) and not necessarily those of the NIHR or the Department of
   Health and Social Care.
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NR 73
TC 0
Z9 0
U1 2
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD JUN
PY 2026
VL 10
IS 3
AR zrag027
DI 10.1093/bjsopen/zrag027
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IE2KZ
UT WOS:001769599800001
PM 42159327
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lafin, L
   de Bragard, EA
   Lechartier, A
AF Lafin, L.
   Autard de Bragard, E.
   Lechartier, A.
TI Management of locking compression plate infection with negative pressure
   therapy in a neonatal foal
SO EQUINE VETERINARY EDUCATION
LA English
DT Article; Early Access
DE horse; foal; fracture; NPWT; surgical site infection
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; BACTERIAL LOAD
AB A neonatal foal presenting with surgical site infection following internal fixation of a transverse, displaced fracture of the distal third left metatarsus was successfully managed using negative pressure wound therapy (NPWT). Negative pressure wound therapy promoted rapid formation of healthy granulation tissue, resolution of infection and stability of the implant until bone healing was achieved while minimising hospital personal exposure to multiple-drug-resistant pathogens.
C1 [Lafin, L.; Autard de Bragard, E.; Lechartier, A.] Ctr Hosp Veterinaire Equin Meheudin, Ecouche Les Vallees, France.
RP Lafin, L (通讯作者)，Ctr Hosp Veterinaire Equin Meheudin, Ecouche Les Vallees, France.
EM llafin@cvem.fr
CR Ahern BJ, 2010, VET SURG, V39, P588, DOI 10.1111/j.1532-950X.2010.00705.x
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0957-7734
EI 2042-3292
J9 EQUINE VET EDUC
JI Equine Vet. Educ.
PD 2026 MAY 20
PY 2026
DI 10.1111/eve.70122
EA MAY 2026
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA IF3OP
UT WOS:001770355500001
DA 2026-07-24
ER
PT J
AU Xiao, SA
   Liu, N
   Cui, YW
   Li, H
   Dong, YC
   Tang, JZ
   Zhang, H
   Wang, WX
   Bian, YQ
   Li, J
   Li, XY
AF Xiao, Shu-Ao
   Liu, Ni
   Cui, Yi-Wei
   Li, Hang
   Dong, Yu-Chen
   Tang, Jie-Zhang
   Zhang, Hao
   Wang, Wen-Xuan
   Bian, Yong-Qian
   Li, Jing
   Li, Xue-Yong
TI Negative pressure-induced fibroblast activation for wound healing
   through the Piezo1-Ca2+-NFAT3 signaling pathway
SO BURNS & TRAUMA
LA English
DT Article
DE Negative pressure wound therapy; Finite element analysis; Fibroblasts;
   Piezo1; calcineurin/NFAT signaling pathway; Wound healing
ID PROLIFERATION; THERAPY; STIMULATION; MIGRATION; MECHANISM
AB Background Negative pressure wound therapy (NPWT) is widely used to promote wound healing, yet the mechanotransduction mechanisms underlying its efficacy remain unclear because of the absence of precise and controllable in vitro negative pressure loading devices for cellular-level studies. Therefore, this study aims to develop a precise and controllable in vitro negative pressure loading device and to elucidate the mechanotransduction mechanism by which negative pressure activates dermal fibroblasts during wound healing.Methods We developed a high-precision negative pressure loading device compatible with six-well plates, facilitating independent and intelligent control over negative pressure values, durations, and modes for each well. To validate the uniformity and stability of the negative pressure environment, finite element analysis (FEA) was implemented. The mechanism was explored using proteomic profiling of negative pressure-treated fibroblasts, complemented by molecular interrogation of Piezo1 expression and calcium signaling dynamics. The results of functional studies integrated genetic silencing and pharmacological modulation of the pathway, with in vivo confirmation through SD rat-based NPWT experiments.Results FEA confirmed a stable pressure distribution within the negative pressure chamber. The cells experienced predominantly compressive stresses that scaled linearly with the applied pressure, reaching -2 kPa at -40 mmHg. We found that applying a continuous negative pressure of -40 mmHg for 2 hours significantly activated dermal fibroblasts. TMT-based proteomic analysis revealed the upregulation of Piezo1 in negative pressure-treated dermal fibroblasts, which was further confirmed by molecular and immunohistochemical analyses of both cellular and granulation tissue samples. Pharmacological inhibition or knockdown of Piezo1 attenuated negative pressure-induced dermal fibroblast activation in vivo and in vitro. Mechanistically, we determined that Piezo1-mediated Ca2+ influx and the calcineurin/NFAT3 signaling pathway are critically enhanced during this process.Conclusions This study revealed that the Piezo1-Ca2+-NFAT3 mechanotransduction axis is the central pathway that mediates the therapeutic effects of NPWT. This work lays the foundational groundwork for elucidating the biomechanical mechanisms of negative pressure and reveals new approaches for research in tissue engineering and regenerative medicine.
C1 [Xiao, Shu-Ao] Fourth Mil Med Univ, Xijing Hosp, Dept Plast Surg, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
   [Liu, Ni] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Pain Management, 277,Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Cui, Yi-Wei; Dong, Yu-Chen; Tang, Jie-Zhang; Bian, Yong-Qian; Li, Jing] Fourth Mil Med Univ, Tangdu Hosp, Dept Burn & Plast Surg, 1,Xinsi Rd, Xian 710000, Shaanxi, Peoples R China.
   [Li, Hang; Li, Xue-Yong] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Burn Plast & Wound Repair Surg, 157,West Fifth Rd, Xian 710004, Shaanxi, Peoples R China.
   [Zhang, Hao] 927th Hosp Joint Logist Support Force, Dept Burn & Plast Surg, 3 Yushui Rd, Puer 665000, Yunnan, Peoples R China.
   [Wang, Wen-Xuan] Fourth Mil Med Univ, Xijing Hosp, Burn & Dermatol Surg, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Xi'an Jiaotong University; Air Force
   Medical University; Xi'an Jiaotong University; Air Force Medical
   University
RP Bian, YQ; Li, J (通讯作者)，Fourth Mil Med Univ, Tangdu Hosp, Dept Burn & Plast Surg, 1,Xinsi Rd, Xian 710000, Shaanxi, Peoples R China.; Li, XY (通讯作者)，Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Burn Plast & Wound Repair Surg, 157,West Fifth Rd, Xian 710004, Shaanxi, Peoples R China.
EM yongqianbian@163.com; lijing02@fmmu.edu.cn; lixueyong641123@163.com
FU Key R&D plan of Shaanxi Province [2024SF-YBXM-208]
FX This research was supported by the Key R&D plan of Shaanxi Province
   (number: 2024SF-YBXM-208).
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NR 42
TC 0
Z9 0
U1 2
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2321-3868
EI 2321-3876
J9 BURNS TRAUMA
JI Burns Trauma
PY 2026
VL 14
AR tkag007
DI 10.1093/burnst/tkag007
PG 18
WC Emergency Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Dermatology; Surgery
GA IG1CC
UT WOS:001770864300001
PM 42181011
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Sharda, R
   Subair, M
AF Sharda, Renu
   Subair, Mohsina
TI Complications of Negative Pressure Wound Therapy: A Narrative Review
   with Clinical Insights
SO INDIAN JOURNAL OF SURGERY
LA English
DT Review; Early Access
DE Negative Pressure Wound Therapy; Complications; Pitfalls; Wound care;
   NPWT; Guidance
ID VACUUM-ASSISTED CLOSURE; BACTERIAL-GROWTH; RIGID DISC; MANAGEMENT;
   INFECTIONS; NPWT; EXPERIENCE; FOAMS; PAIN; INSTILLATION
AB Negative Pressure Wound Therapy (NPWT), initially developed for the management of chronic wounds, has evolved into an essential modality in modern wound care. By promoting granulation tissue formation, reducing edema, improving perfusion, and facilitating wound closure, NPWT has expanded the therapeutic options for managing complex wounds. However, alongside these benefits, several limitations, technical challenges, and potential complications have also been reported, highlighting the importance of awareness for safe and effective application. This narrative review summarizes the spectrum of complications associated with NPWT and provides practical insights into their mechanisms, risk factors, and preventive strategies. A narrative review of the literature addressing complications and adverse events associated with NPWT was performed. A comprehensive search of PubMed, MEDLINE, EMBASE, and the Cochrane Library was conducted using the terms: 'negative pressure wound therapy complications', 'NPWT adverse events', 'vacuum-assisted closure bleeding/infection', and related MeSH terms. Articles published from 2000 to 2024 were predominantly included. Given the narrative design, formal PRISMA methodology was not applied; however, a transparent search strategy was followed. Relevant information was synthesized and integrated with clinical observations from routine surgical practice. Complications were categorized into four broad domains: device-related, technique-related, wound-related, and patient-related factors. Device-related issues include system alarms, loss of seal, tube blockage and suction malfunction. Technique-related complications arise from improper dressing application, inadequate pressure settings, or inappropriate device handling. Wound-related complications include bleeding, pain, infection, and retention of dressing materials. Despite its proven efficacy, NPWT is not devoid of complications. A thorough understanding of potential adverse events, careful patient selection, meticulous application technique, and vigilant monitoring are critical for optimizing treatment outcomes.
C1 [Sharda, Renu] Post Grad Inst Med Educ & Res PGIMER, Dept Plast Surg, Chandigarh, India.
   [Subair, Mohsina] Welcare Hosp, Dept Plast Surg, Kochi, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Subair, M (通讯作者)，Welcare Hosp, Dept Plast Surg, Kochi, India.
EM renusurgeon29@gmail.com; mohsinasubair1989@gmail.com
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NR 72
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD 2026 MAY 20
PY 2026
DI 10.1007/s12262-026-04612-z
EA MAY 2026
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IG5AT
UT WOS:001771131200001
DA 2026-07-24
ER
PT J
AU Hiyama, A
   Sakai, D
   Hattori, N
   Watanabe, M
AF Hiyama, Akihiko
   Sakai, Daisuke
   Hattori, Nobuaki
   Watanabe, Masahiko
TI Risk stratification of surgical site infection in high-risk spine
   surgery under prophylactic ciNPWT
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Closed-incision negative pressure wound therapy; Surgical site
   infection; Spine surgery; High-risk patients; Risk stratification; PICO
   7
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; LUMBAR FUSION;
   MANAGEMENT; DISEASE
AB Background This retrospective observational single-center cohort study evaluated real-world outcomes of prophylactic closed-incision negative pressure wound therapy (ciNPWT) in high-risk spine surgery patients and explored the distribution of surgical site infection (SSI) across cumulative risk burden (RiskN) strata within this selectively treated cohort. Methods We reviewed consecutive spine surgery patients who received prophylactic single-use PICO 7 (Smith & Nephew) ciNPWT immediately after wound closure between April 2023 and October 2025. High-risk status was defined according to Japanese reimbursable criteria. Cumulative risk burden was quantified as RiskN (1, 2, or >= 3). SSI was defined based on CDC criteria and reported with Wilson 95% confidence intervals (CIs). Results A total of 104 patients were analyzed (mean age 70.2 +/- 12.7 years; BMI 24.1 +/- 4.5 kg/m & sup2;). The mean RiskN was 1.50 +/- 0.78 (RiskN 1: 68 patients; RiskN 2: 22; RiskN 3-4: 14). The most frequent risk factor was hypoalbuminemia (57/104, 54.8%). Overall SSI occurred in 4 of 104 patients (3.8%; 95% CI, 1.5-9.5%). SSI rates were 2.9% (2/68) in RiskN 1, 0% (0/22) in RiskN 2, and 14.3% (2/14) in RiskN >= 3. Surgical procedures were mainly lumbar posterior (56/104, 53.8%) and thoracolumbar posterior (21/104, 20.2%); SSIs occurred after thoracolumbar posterior surgery (2/21), cervical posterior surgery (1/14), and lumbar posterior surgery (1/56). The most commonly used dressing size was 15 & times; 15 cm (51/104, 49.0%). Conclusions In this selectively treated, reimbursement-linked high-risk spine surgery cohort managed with prophylactic ciNPWT, SSI was uncommon overall but remained observed in patients with higher cumulative risk burden. RiskN was used to contextualize residual SSI risk within this pragmatically treated population. The observed SSI rate should be interpreted as a residual ("breakthrough") infection rate within a high-risk population. As a descriptive study without a control group, this study does not directly demonstrate the treatment effect of ciNPWT. Further comparative studies are needed to determine its incremental benefit, cost-effectiveness, and appropriate indications.
C1 [Hiyama, Akihiko; Sakai, Daisuke; Hattori, Nobuaki; Watanabe, Masahiko] Tokai Univ, Sch Med, Dept Orthopaed Surg, Surg Sci, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan.
C3 Tokai University
RP Hiyama, A (通讯作者)，Tokai Univ, Sch Med, Dept Orthopaed Surg, Surg Sci, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan.
EM a.hiyama@tokai.ac.jp
RI Sakai, Daisuke/X-9164-2019; Hiyama, Akihiko/AAW-7362-2021
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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NR 24
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD APR 11
PY 2026
VL 27
IS 1
AR 438
DI 10.1186/s12891-026-09826-6
EA APR 2026
PG 10
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA II9NC
UT WOS:001772787300004
PM 41965669
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Gunga, Z
   Rigollot, A
   Godat, A
   Niclauss, L
   Kirsch, M
AF Gunga, Ziyad
   Rigollot, Augustin
   Godat, Agnes
   Niclauss, Lars
   Kirsch, Matthias
TI First-in-Human Intramediastinal Taurolidine Irrigation for Candida
   albicans Mediastinitis After Biological Bentall Procedure
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Article
DE mediastinitis; taurolidine; <italic>Candida albicans</italic>; novel
   procedure; fungal infection; cardiac surgery
ID PREVENTION; MANAGEMENT; SURGERY; ASSOCIATION; INFECTIONS
AB Background: Post-sternotomy mediastinitis remains a devastating complication of cardiac surgery. Although most cases are bacterial, fungal mediastinitis due to Candida albicans is rare, aggressive, and particularly difficult to treat because of biofilm formation, prosthetic involvement, and limited penetration of systemic antifungal agents into infected tissues. Taurolidine is a taurine-derived antimicrobial compound with broad antibacterial, antifungal, and anti-biofilm properties that has shown promising results in catheter-related infection prevention and cardiac implantable electronic device surgery. Case summary: We report, to our knowledge, the first intramediastinal use of taurolidine for Candida albicans mediastinitis after biological Bentall surgery. Following urgent resternotomy and extensive debridement, 200 mL of taurolidine solution was instilled into the mediastinum for 60 min, then aspirated. Postoperatively, taurolidine irrigation via mediastinal drainage was combined with negative-pressure wound therapy and systemic antifungal treatment. Results: Rapid microbiological sterilization was achieved, inflammatory markers normalized, and follow-up computed tomography demonstrated complete resolution of mediastinal infection. Delayed sternal closure was then performed successfully without recurrence at 6-month follow up. Conclusion: To our knowledge, this represents the first reported use of intramediastinal taurolidine irrigation for fungal mediastinitis following cardiac surgery. Intramediastinal taurolidine irrigation may represent a promising adjunctive strategy for mediastinitis after cardiac surgery in high-risk patients. Further clinical evaluation is warranted.
C1 [Gunga, Ziyad; Rigollot, Augustin; Godat, Agnes; Niclauss, Lars; Kirsch, Matthias] Lausanne Univ Hosp, Ctr Hosp Univ Vaudois, Dept Cardiovasc Surg, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Gunga, Z (通讯作者)，Lausanne Univ Hosp, Ctr Hosp Univ Vaudois, Dept Cardiovasc Surg, CH-1011 Lausanne, Switzerland.
EM ziyad.gunga@chuv.ch; agnes.godat@chuv.ch; lars.niclauss@chuv.ch;
   matthias.kirsch@chuv.ch
RI Gunga, Ziyad/PCT-2460-2025
OI Gunga, Ziyad/0009-0008-0276-2160
CR Abu-Omar Y, 2017, EUR J CARDIO-THORAC, V51, P10, DOI 10.1093/ejcts/ezw326
   Bisseling TM, 2010, CLIN NUTR, V29, P464, DOI 10.1016/j.clnu.2009.12.005
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NR 22
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD MAY 12
PY 2026
VL 13
IS 5
AR 204
DI 10.3390/jcdd13050204
EA MAY 2026
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA IL8RA
UT WOS:001774763900001
PM 42188090
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wrzesniak, Z
   Wilk, B
   Pulik, L
   Guzik, G
   Legosz, P
AF Wrzesniak, Zofia
   Wilk, Bartlomiej
   Pulik, Lukasz
   Guzik, Grzegorz
   Legosz, Pawel
TI Optimizing Outcomes in Total Femur Replacement: Complications,
   Management Strategies, and Lessons Learned
SO MEDICINA-LITHUANIA
LA English
DT Article
DE total femur replacement; arthroplasty; endoprosthesis
ID SALVAGE; ARTHROPLASTY; FAILURE
AB Background and Objectives: Total femoral replacement (TFR) was originally developed for limb salvage following the resection of malignant tumors. Over time, its indications have expanded, now serving as a reconstructive option for failed endoprosthetic replacements and severe trauma cases. Despite its advantages, TFR is a highly complex surgical procedure associated with significant complication rates. This study aims to analyze the management of complications and propose strategies to mitigate associated risks. Materials and Methods: This is a retrospective study conducted on patients from two independent hospitals who underwent TFR for different reasons. Results: Nineteen patients were included: eight underwent TFR for oncological indications, while 11 had the procedure as a revision following failed endoprosthetic arthroplasty or trauma. Postoperative complications were observed in 10 patients (53%), including hip dislocation (21%), mechanical implant failure (11%), infection (21%), wound healing complications (26%), and metal allergy symptoms (5%). Revision surgery was required in six patients (32%), but no cases necessitated amputation. Conclusions: TFR is associated with a high risk of complications, with infection and wound healing issues being the most prevalent. In our experience effective complication management strategies should include early intervention, considering TFR at an earlier stage in non-oncological patients to minimize multiple revision surgeries; allergy screening, assessing for potential metal hypersensitivity preoperatively; dislocation prevention, implementing dual mobility bearings to reduce instability; infection control, utilizing intraoperative local antibiotic therapy in revision cases; and wound management, applying vacuum-assisted closure (VAC) therapy postoperatively to enhance wound healing. Implementing these strategies may improve patient outcomes and reduce the burden of complications associated with TFR.
C1 [Wrzesniak, Zofia; Wilk, Bartlomiej] Med Univ Warsaw, Fac Med, Zwirki i Wigury 61, PL-02091 Warsaw, Poland.
   [Pulik, Lukasz; Legosz, Pawel] Med Univ Warsaw, Dept Orthopaed & Traumatol, Ul Lindleya 4, PL-02005 Warsaw, Poland.
   [Guzik, Grzegorz] Podkarpacki Reg Oncol Ctr, Oncol Orthopaed Dept, Ul Ks Jozefa Bielawskiego 18, PL-36200 Brzozow, Poland.
C3 Medical University of Warsaw; Medical University of Warsaw
RP Wrzesniak, Z (通讯作者)，Med Univ Warsaw, Fac Med, Zwirki i Wigury 61, PL-02091 Warsaw, Poland.
EM zofia.wrzesniak@wp.pl; wilk.wilkbartlomiej@gmail.com;
   lukasz.pulik@wum.edu.pl; grzegorz.guzik@vp.pl; pawel.legosz@wum.edu.pl
RI Łęgosz, Paweł/ABB-5424-2020; Pulik, Łukasz/AAI-7943-2020
CR Adzhar AL, 2023, MALAYS ORTHOP J, V17, P21, DOI 10.5704/MOJ.2307.004
   Akil Samuel, 2018, J Clin Orthop Trauma, V9, P3, DOI [10.1016/j.jcot.2017.10.003, 10.1016/j.jcot.2017.10.003]
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   Berend KR, 2004, CLIN ORTHOP RELAT R, P162, DOI 10.1097/01.blo.0000142351.88039.e8
   BUCHMAN J, 1965, Bull Hosp Joint Dis, V26, P21
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   Guerra J, 2021, GERIATR ORTHOP SURG, V12, DOI 10.1177/21514593211019977
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   Idris N, 2023, BMC MUSCULOSKEL DIS, V24, DOI 10.1186/s12891-023-06643-z
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD APR 24
PY 2026
VL 62
IS 5
AR 809
DI 10.3390/medicina62050809
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IM0XM
UT WOS:001774915900001
PM 42195062
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Nacea, DI
   Enescu, DM
   Pertea, M
   Mitrache, P
   Gavrila, IM
   Tatar, R
AF Nacea, Doina Iulia
   Enescu, Dan Mircea
   Pertea, Mihaela
   Mitrache, Petruta
   Gavrila, Iulia Mihaela
   Tatar, Raluca
TI Integrating Negative-Pressure Wound Therapy in the Therapeutic Protocol
   of Extensive Pediatric Burns: Current Practice and Further Treatment
   Decision Algorithm
SO MEDICINA-LITHUANIA
LA English
DT Article
DE pediatric burns; extensive burns; negative-pressure wound therapy; burn
   local treatment; electrical burns
ID MANAGEMENT; EXPERIENCE; EFFICACY
AB Background and Objectives: Extensive burns are devastating injuries, especially in children, associating high risk of morbidity and mortality in the absence of immediate and appropriate treatment. Negative-pressure wound therapy (NPWT) has emerged as a versatile tool for the local treatment of burn wounds. This study aims to present our approach in using NPWT for extensive burns in children, emphasizing the indications and outcomes of these very challenging cases, and proposing an algorithm for NPWT use for extensive burn patients, even in low-resource settings. Materials and Methods: We retrospectively analyzed pediatric burn patients admitted between January 2020 and December 2024, selecting the cases with at least 20% TBSA burn and the application of NPWT during treatment, recording indications and parameters of use, treatment period, and results. Results: We identified 12 patients with a burn surface ranging from 20% to 80% TBSA, caused by high-voltage electrical current (6 cases), flame (4 cases), and scalds (2 cases). NWPT was used for 3-25% TBSA for obtaining granulation tissue in very deep burn wounds with bone and tendon exposure, for reducing edema and enhancing spontaneous re-epithelialization in intermediate circumferential burns, and for preparing the wound bed for re-grafting after local infection and graft failure. There were no complications related with the NPWT use and no fatalities. Conclusions: NPWT represents a reliable option for several clinical situations in local burn treatment, for temporary closure of burn areas, graft fixation, burn wound preparation, local infection control, or enhancing re-epithelialization. The proposed algorithm offers a comprehensive overview of indications of NPWT for burn local management and may guide clinical decisions, easing the identification of the best situation and moment to use the device. Our study contributes to the body of knowledge that enforces the evidence of the safe and effective use of NPWT for burn management in the pediatric population.
C1 [Nacea, Doina Iulia; Enescu, Dan Mircea; Mitrache, Petruta; Tatar, Raluca] Carol Davila Univ Med & Pharm, Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg, Bucharest 020021, Romania.
   [Nacea, Doina Iulia; Enescu, Dan Mircea; Mitrache, Petruta; Tatar, Raluca] Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg & Burns, Bucharest 010621, Romania.
   [Pertea, Mihaela] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Plast Surg & Reconstruct, Iasi 700115, Romania.
   [Pertea, Mihaela] Sf Spiridon Emergency Cty Hosp, Dept Plast Surg & Reconstruct Microsurg, Iasi 700111, Romania.
   [Gavrila, Iulia Mihaela] Carol Davila Univ Med & Pharm, St John Clin Emergency Hosp, Dept Plast Reconstruct Surg, Bucharest 020021, Romania.
   [Gavrila, Iulia Mihaela] St John Clin Emergency Hosp, Dept Plast Reconstruct Surg, Bucharest 042122, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Mitrache, P (通讯作者)，Carol Davila Univ Med & Pharm, Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg, Bucharest 020021, Romania.; Mitrache, P (通讯作者)，Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg & Burns, Bucharest 010621, Romania.; Pertea, M (通讯作者)，Grigore T Popa Univ Med & Pharm, Fac Med, Dept Plast Surg & Reconstruct, Iasi 700115, Romania.; Pertea, M (通讯作者)，Sf Spiridon Emergency Cty Hosp, Dept Plast Surg & Reconstruct Microsurg, Iasi 700111, Romania.
EM iulia.nacea@umfcd.ro; mihaela.pertea@umfiasi.ro;
   petruta.mitrache@drd.umfcd.ro; raluca.tatar@umfcd.ro
RI Nacea, Doina Iulia/OLR-9981-2025; Tatar, Raluca/AAF-4712-2021
CR Badoiu SC, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25147630
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   Seth I, 2024, PLAST AESTHET RES, V11, DOI 10.20517/2347-9264.2024.05
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   Teng SC, 2016, INT WOUND J, V13, P15, DOI 10.1111/iwj.12641
   Thomson Christopher J, 2004, Can J Plast Surg, V12, P35
   World Health Organization, 2022, INT STAT CLASSIFICAT
   World Health Organization Burns, US
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   Zwierello W, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24043749
NR 54
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD APR 30
PY 2026
VL 62
IS 5
AR 852
DI 10.3390/medicina62050852
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IM2AX
UT WOS:001774992400001
PM 42195105
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kuzmiuk-Glembin, I
   Bialomyzy, A
   Sadowski, M
   Biedunkiewicz, B
   Tylicki, L
   Nieweglowski, T
AF Kuzmiuk-Glembin, Izabella
   Bialomyzy, Agnieszka
   Sadowski, Michal
   Biedunkiewicz, Bogdan
   Tylicki, Leszek
   Nieweglowski, Tomasz
TI The Combined Use of Ozone and Negative Pressure Wound Therapy in the
   Management of Diabetes-Related Foot Disease: A Retrospective Exploratory
   Cohort Study
SO MEDICINA-LITHUANIA
LA English
DT Article
DE ozone treatment; diabetic foot syndrome; negative pressure therapy;
   diabetes mellitus
ID OZONATED AUTOHEMOTHERAPY; ATHEROSCLEROTIC ISCHEMIA; RISK
AB Background and Objectives: Diabetes mellitus (DM) is a major global health concern, with diabetes-related foot disease (DFD) representing one of its most severe complications, often resulting in chronic infection, osteomyelitis, and limb amputation. Conventional therapies frequently fail in refractory cases, necessitating novel adjunctive strategies. Ozone therapy (OT) possesses antimicrobial, immunomodulatory, and oxygen-enhancing properties, while negative pressure wound therapy (NPWT) facilitates granulation, exudate removal, and tissue perfusion. This study explored the combined efficacy of OT and NPWT in advanced DFD. Materials and Methods: An exploratory, retrospective, observational cohort study was conducted at a specialized wound care center in Gda & nacute;sk, Poland, between 2019 and 2022. The study included 30 patients (n = 30) with refractory DFD involving both soft tissue and bone infection who had not responded to previous conventional treatment. The analyzed treatment approach consisted of surgical debridement, application of topical ozonated preparations, and (NPWT) with instillation of ozonated saline administered over a six-week period. Clinical outcomes included wound healing assessed using the Wagner classification and wound volume reduction, pain intensity measured using the Numeric Rating Scale (NRS), inflammatory biomarkers (C-reactive protein [CRP] and procalcitonin [PCT]), and microbiological characteristics of wound cultures. Statistical analyses were performed using the Wilcoxon signed-rank test and the chi-square test, and regression modeling was applied to identify potential predictors of therapeutic response. Statistical significance was defined as p < 0.05. Results: By week six, 100% of ulcers improved to Wagner stage <= 1, with 26.7% achieving stage 0. Median wound volume decreased from 5.5 cm(3) to 0 cm(3) (p < 0.001). Pain scores declined from 7.2 +/- 0.96 points to 0.2 +/- 0.5 points (p < 0.001). CRP and PCT levels decreased significantly (p < 0.001), and microbiological clearance was observed in all cases. Higher body mass index (BMI) was associated with poorer pain reduction. Conclusions: The combination of standard wound care with OT and NPWT was associated with clinically relevant improvements in wound healing, infection control, systemic inflammation, and pain reduction in patients with refractory DFD. Although limited by a non-controlled design and small cohort size, these findings support further randomized controlled trials to define the role of this combined approach in integrated diabetic foot care.
C1 [Kuzmiuk-Glembin, Izabella; Biedunkiewicz, Bogdan; Tylicki, Leszek] Med Univ Gdansk, Univ Clin Ctr, Dept Nephrol Transplantol & Internal Dis, PL-80214 Gdansk, Poland.
   [Bialomyzy, Agnieszka; Sadowski, Michal; Nieweglowski, Tomasz] Wound Care Clin, Nonpubl Healthcare Ctr, ETER MED, PL-80822 Gdansk, Poland.
C3 Fahrenheit Universities; Medical University Gdansk
RP Kuzmiuk-Glembin, I (通讯作者)，Med Univ Gdansk, Univ Clin Ctr, Dept Nephrol Transplantol & Internal Dis, PL-80214 Gdansk, Poland.
EM iza_kuzmiuk@gumed.edu.pl; tn@etermed.pl
RI Kuźmiuk-Glembin, Izabella/AAS-8938-2020; /R-1168-2018; Tylicki,
   Leszek/T-8466-2018
FU European Regional Development Fund under the Smart Growth Operational
   Programme 2014-2020
FX This research was conducted using clinical material and infrastructure
   as a part of a project co-financed by the European Regional Development
   Fund under the Smart Growth Operational Programme 2014-2020, Measure 2.1
   POIR, concerning the establishment of a Research and Development Centre
   at ETER-MED Sp. z o.o. for the development and implementation of novel
   therapeutic and technological methods in ozone therapy. The
   retrospective scientific analysis and manuscript preparation were
   performed subsequently.
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NR 25
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD APR 27
PY 2026
VL 62
IS 5
AR 827
DI 10.3390/medicina62050827
EA APR 2026
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IO4PP
UT WOS:001776525300001
PM 42195080
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhou, JQ
   Yu, JJ
   Hu, TS
   Li, JY
   Ding, CC
   Chen, LH
   Zhang, M
AF Zhou, Jiaqi
   Yu, Jingjing
   Hu, Tianshuo
   Li, Jingyi
   Ding, Cuicui
   Chen, Lihui
   Zhang, Min
TI Nanosheets doped collagen-based composite sponge dressing with
   integrated negative pressure wound therapy, photothermal, and gas
   therapies for wound healing
SO BIOMATERIALS ADVANCES
LA English
DT Article
DE Negative pressure wound therapy (NPWT); Photothermal therapy (PTT);
   Polyvinyl alcohol (PVA); Sponge dressing; Photothermal antibacterial
ID OXIDE
AB Polyvinyl alcohol (PVA) sponges are widely utilized as wound dressings, yet they face limitations in clinical practice, particularly in addressing bacterial infection. Herein, a multifunctional composite sponge dressing is developed by incorporating collagen (COL) and a graphene oxide (GO)/BNN6 (a nitric oxide (NO) donor) assembly into a PVA matrix. The resulting GO/BNN6/PVA/COL composite sponge exhibits a three-dimensional porous network, high porosity, excellent liquid absorption, and favorable shape retention. Benefiting from these features, the composite sponge demonstrates efficient negative pressure drainage performance in vitro, achieving a drainage flux of 3515.0 mL center dot s- 1 center dot m- 2 at 16 kPa, indicating its potential applicability for negative pressure wound therapy (NPWT). Moreover, under near-infrared (NIR) irradiation, GO provides significant photothermal conversion, allowing the sponge to serve as a photothermal therapy (PTT) agent. The localized heat simultaneously triggers the controlled release of NO from BNN6, yielding a combined photothermal and NO-mediated antibacterial effect with inhibition rates exceeding 96% against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Notably, in vivo experiments demonstrate that the GO/BNN6/PVA/COL sponge under NIR irradiation effectively suppresses infection, accelerates wound closure, and promotes granulation tissue formation and skin regeneration. This work presents a versatile sponge dressing that combines the key functions required for NPWT, on-demand PTT, and gas-based antibacterial treatment, demonstrating promising potential for advanced wound management.
C1 [Zhou, Jiaqi; Hu, Tianshuo; Chen, Lihui; Zhang, Min] Fujian Agr & Forestry Univ, Coll Mat Engn, Fuzhou 350002, Peoples R China.
   [Yu, Jingjing; Ding, Cuicui] Fujian Univ Technol, Sch Urban & Environm Engn, Fuzhou 350118, Peoples R China.
   [Li, Jingyi] Fujian Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Fuzhou 350122, Peoples R China.
   [Zhang, Min] Natl Forestry & Grassland Adm, Key Lab Plant Fiber Funct Mat, Fuzhou 350108, Peoples R China.
C3 Fujian Agriculture & Forestry University; Fujian University of
   Technology; Fujian Medical University
RP Zhang, M (通讯作者)，Fujian Agr & Forestry Univ, Coll Mat Engn, Fuzhou 350002, Peoples R China.; Ding, CC (通讯作者)，Fujian Univ Technol, Sch Urban & Environm Engn, Fuzhou 350118, Peoples R China.
EM dingcuicui.1124@163.com; mzhang@fafu.edu.cn
RI ; Chen, lihui/IXD-5425-2023
OI Chen, Li Hui/0009-0002-9978-9509; 
FU National Natural Science Foundation of China [22178056]; Outstanding
   Youth Natural Science Foundation of Fujian Province [2024J09047]; Major
   science and technology projects of Fujian Province [2023YZ038001];
   Fuzhou Science and Technology Major Project [2023-ZD-008]
FX This work was financially supported by the National Natural Science
   Foundation of China (Grant No. 22178056) , Outstanding Youth Natural
   Science Foundation of Fujian Province (Grant No. 2024J09047) , Major
   science and technology projects of Fujian Province (Grant No.
   2023YZ038001) , and Fuzhou Science and Technology Major Project
   (2023-ZD-008) .
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   Zuo Jun, 2024, J WOUND CARE, V33
NR 56
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2772-9508
J9 BIOMATER ADV
JI Biomater. Adv.
PD SEP
PY 2026
VL 186
AR 214942
DI 10.1016/j.bioadv.2026.214942
EA MAY 2026
PG 12
WC Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA IR9YF
UT WOS:001778925100001
PM 42150292
DA 2026-07-24
ER
PT J
AU Hu, H
   Zou, W
   Luo, XQ
   Yu, SJ
   Wang, JW
   Hu, XL
   Yu, F
   Ji, R
AF Hu, Hang
   Zou, Wen
   Luo, Xiaoqian
   Yu, Shaojun
   Wang, Jianwei
   Hu, Xinlei
   Yu, Feng
   Ji, Ran
TI Case Report: Multidisciplinary collaboration for the treatment of severe
   necrotizing fasciitis in the perineum caused by rectal cancer
   perforation
SO FRONTIERS IN SURGERY
LA English
DT Article
DE Fournier's gangrene; multidisciplinary care; patient-centered care;
   rectal cancer perforation; staged surgical management
ID FOURNIERS GANGRENE; MORTALITY
AB Fournier's gangrene (FG) is a rare but life-threatening necrotizing fasciitis of the perineum and genital regions. Rectal cancer perforation is an uncommon cause of FG, and optimal management remains challenging. Case presentation: We report a 62-year-old male with rectal cancer complicated by severe FG secondary to rectal perforation. The patient underwent emergency fecal diversion, repeated extensive perineal debridement combined with vacuum-assisted closure (VAC) therapy, and intensive supportive care. Following infection control and clinical stabilization, definitive surgical management was performed, including laparoscopic abdominoperineal resection and reconstruction of the large perineal defect using a vascularized gracilis muscle flap and a gluteus maximus fascia composite flap. At two-month follow-up, the patient demonstrated complete wound healing, stable colostomy function, and recovery of independent daily activities. Conclusions: This case highlights the complexity of managing FG associated with rectal cancer perforation and demonstrates the feasibility of sequential treatment strategies integrating infection control, oncologic resection, and reconstructive surgery.
C1 [Hu, Hang; Zou, Wen] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Burns & Wound Care Ctr, Hangzhou, Zhejiang, Peoples R China.
   [Luo, Xiaoqian; Ji, Ran] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Surg, Hangzhou 310009, Zhejiang, Peoples R China.
   [Yu, Shaojun; Wang, Jianwei; Yu, Feng] Zhejiang Univ, Affiliated Hosp 2,China Natl Minist Educ, Key Lab Canc Prevent & Intervent,Sch Med, Dept Colorectal Surg & Oncol, Hangzhou, Zhejiang, Peoples R China.
   [Yu, Shaojun; Wang, Jianwei; Yu, Feng] Minist Educ, Ctr Med Res & Innovat Digest Syst Tumors, Hangzhou, Peoples R China.
   [Hu, Xinlei] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang
   University
RP Ji, R (通讯作者)，Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Surg, Hangzhou 310009, Zhejiang, Peoples R China.
EM 2320052@zju.edu.cn
FU Young Scientists Fund of the National Natural Science Foundation of
   China [82100807]
FX The author(s) declared that financial support was received for this work
   and/or its publication. The research was supported by the Young
   Scientists Fund of the National Natural Science Foundation of China,
   82100807.
CR Al-Bahri SS, 2023, INT J SURG CASE REP, V104, DOI 10.1016/j.ijscr.2023.107955
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NR 10
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD MAY 15
PY 2026
VL 13
AR 1790699
DI 10.3389/fsurg.2026.1790699
EA MAY 2026
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IS1SS
UT WOS:001779046000001
PM 42222220
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Moscalu, R
   Moscalu, M
   Reid, AJ
   Domingos, M
   Stevens, A
   Wong, JKF
AF Moscalu, Roxana
   Moscalu, Mihaela
   Reid, Adam J.
   Domingos, Marco
   Stevens, Adam
   Wong, Jason K. F.
TI The Underlying Mechanisms and Role of Negative Pressure Wound Therapy in
   Chronic Diabetic Wound Healing: A Systematic Review and Meta-Analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE chronic wound healing; diabetes; diabetic foot ulcers; NPWT
ID FOOT ULCERS; EXPRESSION; INDUCTION
AB Although Negative Pressure Wound Therapy (NPWT) has been increasingly used in wound care to improve impaired healing, there is little scientific evidence supporting its role and underlying biomolecular mechanisms. Aims of the present study are to provide a quantitative analysis of recent literature investigating NPWT in diabetic wound healing focusing on healing duration, wound closure, hospitalisation period and complications, and qualitative insight into studies analysing biomolecular mechanisms. The systematic review and meta-analysis were conducted following PRISMA guidelines (PROSPERO: CRD42024524813). 21 studies published in PubMed, Cochrane Library, EMBASE between 2019 and 2024 were included. Clinical studies indicated NPWT was superior to standard care dressings (SCD), promoting faster wound healing with significantly reduced hospitalisation times by 7.8 days (95% CI: -14.2 to -1.4, p = 0.017), and significantly reduced complications rates, particularly major and minor amputations (95% CI: -10.2 to -1.3, p = 0.01). Mechanistic in vitro and animal studies highlighted NPWT can reduce local inflammation, oxidative stress, support angiogenesis and improve scarring, essential components of normal healing. Although studies suggest NPWT is more effective than SCD for diabetic wound healing, the paucity of studies, small cohorts and scarce outcomes consistency make defining clear conclusions challenging. There is still more evidence required to fully understand NPWT's role in the complex diabetic wound healing.
C1 [Moscalu, Roxana; Reid, Adam J.; Wong, Jason K. F.] Univ Manchester, Fac Biol Med & Hlth, Div Cell Matrix Biol & Regenerat Med, Blond McIndoe Labs,Sch Biol Sci,Manchester Acad Hl, Manchester, England.
   [Moscalu, Mihaela] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Prevent Med & Interdisciplinar, Iasi, Romania.
   [Reid, Adam J.; Wong, Jason K. F.] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Wythenshawe Hosp, Dept Plast Surg & Burns, Manchester, England.
   [Domingos, Marco] Univ Manchester, Sch Mech Aerosp & Civil Engn, Manchester, England.
   [Stevens, Adam] Univ Manchester, St Marys Hosp, Fac Biol Med & Hlth, Tommys Maternal & Fetal Hlth Res Ctr, 5th Floor, Manchester, England.
C3 University of Manchester; Grigore T Popa University of Medicine &
   Pharmacy; University of Manchester; Wythenshawe Hospital NHS Foundation
   Trust; Wythenshawe Hospital; Manchester University NHS Foundation Trust;
   University of Manchester; University of Manchester
RP Moscalu, R (通讯作者)，Univ Manchester, Fac Biol Med & Hlth, Div Cell Matrix Biol & Regenerat Med, Blond McIndoe Labs,Sch Biol Sci,Manchester Acad Hl, Manchester, England.
EM roxana.moscalu@postgrad.manchester.ac.uk
RI Moscalu, Mihaela/ABA-9799-2020; Reid, Adam/G-4460-2014
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NR 52
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN 1
PY 2026
VL 23
IS 6
AR e70961
DI 10.1111/iwj.70961
PG 18
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IU4RZ
UT WOS:001780602000001
PM 42220094
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Nikolic, D
   Manojlovic, V
   Budinski, S
   Petrovic, K
   Nikolic, MB
AF Nikolic, Dragan
   Manojlovic, Vladimir
   Budinski, Slavko
   Petrovic, Katarina
   Nikolic, Marijana Basta
TI Predictive Factors for Negative Pressure Wound Therapy Success in
   Diabetic Neuropathic Foot Ulcers: Development and Internal Validation of
   a Random Forest Model
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article; Early Access
DE diabetic foot ulcer; negative pressure wound therapy; random forest;
   prediction model; wound healing
ID VACUUM-ASSISTED CLOSURE
AB Negative pressure wound therapy (NPWT) shows variable outcomes in diabetic neuropathic foot ulcers. This study developed and internally validated a Random Forest prediction model for NPWT treatment success in 343 patients treated between 2018 and 2024. The model was developed using 70% training (n = 240) and 30% validation (n = 103) split. Treatment success (complete closure or >80% area reduction within 16 weeks) occurred in 240 patients (69.9%). The Random Forest model achieved validation set area under the curve of 0.89 (95% CI: 0.84-0.94), accuracy of 85.2%, sensitivity of 86.5%, and specificity of 82.8%. Exploratory analysis using complete wound closure alone yielded comparable discrimination (AUC 0.87). Permutation importance identified HbA1c (25.4%), ulcer size (20.8%), and estimated glomerular filtration rate (eGFR, 18.2%) as the strongest predictors. In multivariable logistic regression, HbA1c > 8.5% (OR 3.90), ulcer size >15 cm(2) (OR 3.02), and eGFR <60 mL/min/1.73 m(2) (OR 2.85) were independently associated with treatment failure. In this single-center cohort, the model showed good internal discrimination for the composite NPWT outcome; external validation is required before clinical use.
C1 [Nikolic, Dragan; Manojlovic, Vladimir; Budinski, Slavko; Petrovic, Katarina; Nikolic, Marijana Basta] Univ Novi Sad, Fac Med, Hajduk Veljkova 3, Novi Sad 21000, Serbia.
   [Nikolic, Dragan; Manojlovic, Vladimir; Budinski, Slavko; Petrovic, Katarina] Univ Clin Ctr Vojvodina, Clin Vasc & Endovasc Surg, Novi Sad, Serbia.
   [Nikolic, Marijana Basta] Univ Clin Ctr Vojvodina, Ctr Radiol, Novi Sad, Serbia.
C3 University of Novi Sad; University of Novi Sad; University of Novi Sad
RP Nikolic, D (通讯作者)，Univ Novi Sad, Fac Med, Hajduk Veljkova 3, Novi Sad 21000, Serbia.
EM DRAGAN.NIKOLIC@mf.uns.ac.rs
RI Nikolic, Dragan/PJB-6880-2026
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NR 17
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD 2026 JUN 1
PY 2026
DI 10.1177/15347346261454761
EA JUN 2026
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV5HH
UT WOS:001781322300001
PM 42220260
DA 2026-07-24
ER
PT J
AU Zhang, HL
   Chen, DS
   Song, Q
   Gong, F
   Li, PL
   Li, Y
   Fei, L
   Yang, YC
   Yu, AY
AF Zhang, Hanlin
   Chen, Desheng
   Song, Qiang
   Gong, Fan
   Li, Peiling
   Li, Yu
   Fei, Le
   Yang, Yanchuan
   Yu, Anyang
TI Staged antibiotic-loaded cement-based reconstruction versus flap-based
   reconstruction for complex diabetic foot defects in patients with
   osteoporosis: a retrospective cohort study
SO FRONTIERS IN SURGERY
LA English
DT Article
DE AB-NPWT; antibiotic-loaded bone cement; diabetic foot; diabetic foot
   osteomyelitis; flap transplantation; limb salvage; osteoporosis;
   retrospective cohort study
ID FRACTURE RISK; MELLITUS; TYPE-1
AB Objective: This retrospective cohort study aimed to compare the clinical efficacy and safety of a staged antibiotic-loaded bone cement combined with negative pressure wound therapy (AB-NPWT) pathway vs. flap transplantation in the treatment of chronic foot ulcers with soft tissue defects in patients with type 2 diabetes mellitus (T2DM) and osteoporosis. Methods: We retrospectively analyzed 56 patients with T2DM and osteoporosis who underwent surgical treatment between January 2020 and December 2024. Treatment allocation was non-randomized and determined by the attending surgeon; no formal sample size calculation was performed. In the AB-NPWT group, 5 patients (17.2%) crossed over to receive local flap coverage as part of the staged pathway. The analysis was not adjusted for multiple comparisons. The AB-NPWT group (n = 29) and flap transplantation group (n = 27) were compared for perioperative parameters, wound healing, limb salvage, complications, and AOFAS scores. Adjusted analyses (multivariable regression and propensity score matching) were performed to account for potential confounding. Results: Operative time and blood loss were significantly lower in the AB-NPWT group (both p < 0.001). At 12 months, complete wound healing (86.2% vs. 88.9%, p = 0.754), limb salvage (93.1% vs. 92.6%, p = 1.000), and median healing time (126 vs. 112 days, p = 0.221) did not differ significantly between groups. Complication rates were similar (24.1% vs. 33.3%, p = 0.446), but profiles differed. AOFAS scores at final follow-up were comparable (72.5 +/- 10.3 vs. 75.8 +/- 11.6, p = 0.270). Conclusions: In this retrospective exploratory cohort, no statistically significant between-group differences were detected in the main clinical outcomes. AB-NPWT was associated with reduced surgical trauma, whereas flap transplantation provided definitive coverage in a single operative session after debridement. Treatment selection should be individualized based on wound characteristics, patient systemic status, and healthcare resources. These findings are hypothesis-generating and require confirmation in larger prospective trials.
C1 [Zhang, Hanlin; Chen, Desheng; Song, Qiang; Gong, Fan; Li, Peiling; Li, Yu; Fei, Le; Yang, Yanchuan; Yu, Anyang] Ningxia Med Univ, Peoples Hosp Ningxia Hui Autonomous Reg, Dept Orthoped Ctr, Yinchuan, Ningxia, Peoples R China.
   [Zhang, Hanlin; Chen, Desheng; Song, Qiang; Gong, Fan; Li, Peiling; Li, Yu; Fei, Le; Yang, Yanchuan; Yu, Anyang] Ningxia Med Univ, Clin Med Coll 3, Yinchuan, Ningxia, Peoples R China.
   [Li, Peiling] Ningxia Med Univ, Peoples Hosp Ningxia Hui Autonomous Reg, Gen Practice Dept, Yinchuan, Ningxia, Peoples R China.
C3 Ningxia Medical University; Ningxia Medical University; Ningxia Medical
   University
RP Chen, DS (通讯作者)，Ningxia Med Univ, Peoples Hosp Ningxia Hui Autonomous Reg, Dept Orthoped Ctr, Yinchuan, Ningxia, Peoples R China.; Chen, DS (通讯作者)，Ningxia Med Univ, Clin Med Coll 3, Yinchuan, Ningxia, Peoples R China.
EM charles_cds@163.com
RI Fei, Le/LKL-1104-2024
FU Natural Science Foundation of Ningxia Province [2023AAC03493,
   2024AAC03503]; Key Research and Development Program of Ningxia
   [2026BEH03006]
FX The author(s) declared that financial support was received for this work
   and/or its publication. The Ningxia Natural Science Foundation
   (2023AAC03493, 2024AAC03503), 2026 Ningxia Hui Autonomous Region key
   research and development plan to introduce special projects
   (2026BEH03006).
CR Armstrong DG, 2023, JAMA-J AM MED ASSOC, V330, P62, DOI 10.1001/jama.2023.10578
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NR 24
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD MAY 20
PY 2026
VL 13
AR 1834390
DI 10.3389/fsurg.2026.1834390
EA MAY 2026
PG 17
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IX9ZA
UT WOS:001782999000001
PM 42245312
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Zhou, CK
   Wang, L
   Gong, ZH
   Xiang, T
AF Zhou, Changkai
   Wang, Lu
   Gong, Zhenhua
   Xiang, Tie
TI Super-tension-reduction suture versus conventional closure for secondary
   closure of infected abdominal incisions
SO FRONTIERS IN SURGERY
LA English
DT Article
DE abdominal wound repair; complication; super-tension-reduction suture;
   surgical site infection; wound healing
ID BURIED VERTICAL MATTRESS
AB Background: Surgical site infection is a common complication after abdominal surgery and is associated with delayed wound healing, prolonged hospitalization, and increased healthcare costs. Secondary closure of infected abdominal incisions after debridement and negative pressure wound therapy remains challenging because tissue edema, inflammation, and skin retraction often lead to excessive wound tension. Super-tension-reduction suture has been proposed to redistribute wound tension and improve tissue perfusion, but its effectiveness in abdominal wound salvage remains unclear. Methods: We performed a retrospective cohort study of patients undergoing abdominal wound salvage for superficial/incisional surgical site infection between January 2020 and May 2024. Patients were categorized according to the final closure technique: standard interrupted suture or super-tension-reduction suture using a modified buried vertical mattress technique. Patient demographics, operative characteristics, and postoperative outcomes were collected. Primary outcomes included recurrent surgical site infection, wound breakdown, hematoma, seroma, fat necrosis, and reoperation. Secondary outcomes included operative duration, time to drain removal, time to suture removal, and length of hospitalization. Propensity score matching was used to mitigate the selection bias. Multivariable binary logistic regression identified significant predictors of complications. Results: We included 89 patients (standard interrupted suture group: 39; super-tension-reduction suture group: 50). In the unmatched cohort, super-tension-reduction suture was associated with lower rates of recurrent surgical site infection (6.0% vs. 23.1%, P = 0.028) and reoperation (4.0% vs. 17.9%, P = 0.039), alongside shorter hospitalization (17.5 vs. 21 days, P < 0.001), despite a modestly longer operative time (24 vs. 20 min, P < 0.001). After 1:1 propensity score matching (n = 58), super-tension-reduction suture group maintained a significantly lower overall complication rate (17.2% vs. 41.4%, P = 0.043). Crucially, multivariable logistic regression identified the super-tension-reduction suture as an independent protective factor against overall complications (aOR: 0.22, 95% CI: 0.08-0.59, P = 0.003) and recurrent surgical site infection (aOR: 0.21, 95% CI: 0.05-0.85, P = 0.028). Conclusion: The super-tension-reduction suture was associated with favorable clinical outcomes in abdominal wound salvage. Compared with conventional closure, it was associated with lower overall complication rates despite a modest increase in operative time. While clinically promising, these observational associations warrant further validation in prospective, randomized trials.
C1 [Zhou, Changkai; Wang, Lu; Gong, Zhenhua; Xiang, Tie] Nantong First Peoples Hosp, Dept Burn & Plast Surg, Nantong, Peoples R China.
C3 Southeast University - China
RP Xiang, T (通讯作者)，Nantong First Peoples Hosp, Dept Burn & Plast Surg, Nantong, Peoples R China.
EM ntyyxt@163.com
CR Allegranzi B, 2011, LANCET, V377, P228, DOI 10.1016/S0140-6736(10)61458-4
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   CDC, 2026, NHSNS PATIENT SAFETY
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD MAY 20
PY 2026
VL 13
AR 1829502
DI 10.3389/fsurg.2026.1829502
EA MAY 2026
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IY1EM
UT WOS:001783080800001
PM 42245306
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kadiyala, S
   Powis, E
   Mirahmadi, A
   Mercado, C
   Yu, S
   Velichala, SR
   Colannino, A
   Hung, I
   Bikoroti, JB
   Kubwimana, O
   Dusingizimana, LR
   Alayande, BT
   Ingabire, JCA
   Byiringiro, JC
   Rodriguez, EK
   Agarwal-Harding, KJ
AF Kadiyala, Samhita
   Powis, Emily
   Mirahmadi, Alireza
   Mercado, Carlos
   Yu, Sion
   Velichala, Suhas Rao
   Colannino, Alyssa
   Hung, Isabella
   Bikoroti, Joel B.
   Kubwimana, Olivier
   Dusingizimana, Lambert R.
   Alayande, Barnabas Tobi
   Ingabire, J. C. Allen
   Byiringiro, Jean Claude
   Rodriguez, Edward K.
   Agarwal-Harding, Kiran J.
TI A Novel Hybrid Training Model for Open Fracture Management in Rwanda
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
AB Open fractures are a critical global health challenge that disproportionately affect individuals in low- and middle-income countries (LMICs), primarily due to road traffic collisions. Surgical management of open fractures is 1 of the 3 essential bellwether procedures identified by The Commission on Global Surgery. LancetWe developed and evaluated a novel hybrid course on open fracture management for surgical trainees and practicing surgeons in Rwanda, combining a self-directed, virtual, pre-course curriculum with a live, in-person workshop in Kigali in June 2025 that was simultaneously live-streamed for virtual attendees. Prerecorded multilingual lectures (English and French) and curated peer-reviewed articles provided foundational knowledge in advance and prepared learners for in-person didactics, case discussions, and skills training. The in-person workshop included didactic sessions and discussions of local clinical cases from Rwanda related to open fracture management and other orthopaedic emergencies, along with hands-on practice in fracture external fixation and negative pressure wound therapy using affordable devices designed for resource-constrained practice. The workshop engaged 160 active learners (37 in-person, 123 virtual) and demonstrated high overall satisfaction among 84 survey respondents, with an average rating of 4.6 out of 5. Self-reported confidence in managing open fractures increased substantially following the course, from a mean rating of 3.83 to 4.69 on a 5-point scale (p < 0.001). Most survey respondents reported that the course moderately or significantly improved their knowledge (96.4%) and would change their clinical practice (96.5%). Participant feedback highlighted opportunities for improvement, including extending the workshop duration to increase hands-on time, expanding the content on complex soft-tissue management, and improving the engagement of remote learners through mechanisms such as the provision of low-cost external fixation models for at-home practice. Future directions include integrating the course into medical student and general practitioner education in Rwanda, adapting it for major surgical conferences regionally and internationally, and continuing to prioritize hands-on training modules. Iterative refinement of the course is planned on the basis of participant feedback.
C1 [Kadiyala, Samhita; Powis, Emily; Mirahmadi, Alireza; Mercado, Carlos; Yu, Sion; Velichala, Suhas Rao; Colannino, Alyssa; Hung, Isabella; Rodriguez, Edward K.; Agarwal-Harding, Kiran J.] Harvard Global Orthopaed Collaborat, Boston, MA 02215 USA.
   [Mirahmadi, Alireza; Rodriguez, Edward K.; Agarwal-Harding, Kiran J.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
   [Bikoroti, Joel B.; Kubwimana, Olivier; Dusingizimana, Lambert R.; Ingabire, J. C. Allen; Byiringiro, Jean Claude] Univ Teaching Hosp Kigali, Kigali, Rwanda.
   [Alayande, Barnabas Tobi] Univ Global Hlth Equ, Ctr Equ Global Surg, Kigali, Rwanda.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center
RP Agarwal-Harding, KJ (通讯作者)，Harvard Global Orthopaed Collaborat, Boston, MA 02215 USA.; Agarwal-Harding, KJ (通讯作者)，Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
EM samhita_kadiyala@hms.harvard.edu; emilypowis@hms.harvard.edu;
   amirahma@bidmc.harvard.edu; carlos@sonaglobal.org;
   sion_yu@universidad.anahuac.mx; suhas@sonaglobal.org;
   alyssa@sonaglobal.org; Isabella_hung@brown.edu;
   drbikorotijoel@gmail.com; oliviee3@gmail.com; duzin83@gmail.com;
   balayande@ughe.org; ijea2000@gmail.com; j.byiringiro@ur.ac.rw;
   ekrodrig@bidmc.harvard.edu; kahardin@bidmc.harvard.edu
RI /AAA-4330-2021; Agarwal-Harding, K/AEU-0518-2022; BYIRINGIRO, JEAN
   CLAUDE/T-9719-2019
OI Mercado, Carlos/0009-0002-1697-1672; RUTAYISIRE, Dusingizimana
   Lambert/0000-0001-5022-6532; Hung, Isabella/0009-0003-5697-9051;
   BYIRINGIRO, JEAN CLAUDE/0000-0002-6445-1797
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   SONA Global Academy, HOM
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD JUN 3
PY 2026
VL 108
IS 11
BP 792
EP 798
DI 10.2106/JBJS.26.00129
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA IY4YG
UT WOS:001783336000017
PM 41973832
DA 2026-07-24
ER
PT J
AU Wang, RF
   Yu, JB
   Guan, YB
   Xu, XS
   Cai, XS
AF Wang, Ruofan
   Yu, Jiongbiao
   Guan, Yubin
   Xu, Xiaosong
   Cai, Xiangsheng
TI Pseudomonas oryzihabitans: An Emerging Opportunistic Pathogen Causing
   Severe Burn Wound Infection After Improper Moxibustion Patch Use in an
   Elderly Diabetic Farmer
SO INFECTION AND DRUG RESISTANCE
LA English
DT Article
DE moxibustion patch; third-degree burn; Pseudomonas oryzihabitans;
   antimicrobial therapy; surgical debridement; negative pressure wound
   therapy; NPWT
AB Background: Pseudomonas oryzihabitans, a Gram-negative opportunistic pathogen, is associated with infected burn wounds in elderly patients with underlying diseases. Moxibustion patch-related deep burns in farmers (due to occupational exposure) often have nonspecific manifestations, causing diagnostic delays. This case highlights the synergistic role of microbiologically guided antimicrobial therapy and surgical intervention. Case Summary: A 71-year-old female farmer with type 2 diabetes and bilateral lower extremity arteriosclerotic occlusive disease developed left lower leg third-degree burn due to improper moxibustion patch use; wound infection occurred after self-treatment. Wound secretion culture confirmed Pseudomonas oryzihabitans (colony count >= 106 CFU/mL) sensitive to cefoperazone-sulbactam. She received microbiologically guided antimicrobial therapy combined with surgical debridement, negative pressure wound therapy (NPWT), and elective split-thickness skin grafting. Postoperatively, infection indicators decreased significantly, the wound healed well, and no recurrence or complications were observed. Conclusion: Elderly patients with underlying diseases are at high risk of such burns and infections. The synergistic application of microbiologically precise antimicrobial therapy and surgical intervention is key to improving efficacy and reducing recurrence.
C1 [Wang, Ruofan; Yu, Jiongbiao; Guan, Yubin; Xu, Xiaosong] Guangdong Pharmaceut Univ, Affiliated Hosp 1, Clin Lab, Guangzhou, Peoples R China.
   [Cai, Xiangsheng] Guangzhou Eleventh Peoples Hosp, Guangzhou Cadre & Talent Hlth Management Ctr, Clin Lab, Guangzhou, Peoples R China.
C3 Guangdong Pharmaceutical University
RP Cai, XS (通讯作者)，Guangzhou Eleventh Peoples Hosp, Guangzhou Cadre & Talent Hlth Management Ctr, Clin Lab, Guangzhou, Peoples R China.
EM xiangshengcai@yeah.net
RI Cai, Xiangsheng/GPS-8610-2022
CR Behera S, 2025, TRIALS, V26, DOI 10.1186/s13063-025-08757-2
   Burgess M, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11193073
   Dayya D, 2022, ADV WOUND CARE, V11, P666, DOI 10.1089/wound.2021.0016
   De Ketele A, 2023, HAND SURG REHABIL, V42, P273, DOI 10.1016/j.hansur.2023.06.002
   Elbehiry A, 2022, AMB EXPRESS, V12, DOI 10.1186/s13568-022-01390-1
   Harsent R, 2022, MICROORGANISMS, V10, DOI 10.3390/microorganisms10020299
   Hosseini M, 2022, BURNS, V48, P860, DOI 10.1016/j.burns.2021.07.017
   Kuromaru Y, 2025, J BURN CARE RES, V46, P581, DOI 10.1093/jbcr/iraf001
   Lahdenperä NI, 2025, BURNS, V51, DOI 10.1016/j.burns.2025.107560
   Pang FH, 2022, BMC PLANT BIOL, V22, DOI 10.1186/s12870-022-03615-8
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   Schaefer TJ, 2025, STATPEARLS
   Su JW, 2025, ADV WOUND CARE, DOI 10.1177/21621918251366606
   Wei Yan, 2025, Zhongguo Zhen Jiu, V45, P1233, DOI 10.13703/j.0255-2930.20240903-k0006
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   Zdziarski P, 2023, FRONT PUBLIC HEALTH, V11, DOI 10.3389/fpubh.2023.1091373
NR 16
TC 0
Z9 0
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2026
VL 19
AR 611045
DI 10.2147/IDR.S611045
PG 8
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA JB7TR
UT WOS:001785564900001
PM 42261283
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kollatos, C
   Sackey, H
   Pantiora, E
   Vorburger, D
   Rocco, N
   Öhrn, C
   Valachis, A
   Eriksson, S
   Karakatsanis, A
AF Kollatos, Christos
   Sackey, Helena
   Pantiora, Eirini
   Vorburger, Denise
   Rocco, Nicola
   Ohrn, Catarina
   Valachis, Antonios
   Eriksson, Staffan
   Karakatsanis, Andreas
TI Clinical and economic impact of incisional negative pressure wound
   therapy in breast surgery: meta-analysis
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Review
ID STANDARD CARE; MASTECTOMY; RISK
AB Background Wound complications after breast surgery are common and contribute to morbidity and healthcare costs. The economic value of prophylactic incisional negative-pressure wound therapy (iNPWT) remains uncertain. This study evaluated the effectiveness and cost-effectiveness of iNPWT in preventing postoperative wound complications (freedom from complication) following breast surgery through a systematic review and meta-analysis.Methods MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched without any restrictions up to 5 March 2025. Randomized trials and prospective or retrospective cohort studies comparing prophylactic iNPWT with standard dressings were included. Two reviewers independently extracted data, assessed risk of bias (RoB 2, ROBINS-I), and graded evidence certainty (GRADE). Random-effects meta-analyses were performed, and cost-effectiveness modelling focused on surgical site infection (SSI).Results Twenty-nine studies including 4904 patients (1817 iNPWT; 3087 controls) were analysed. iNPWT was associated with higher rates of wound dehiscence prevention (RR 1.07, 95% c.i. 1.03 to 1.12), SSI prevention (RR 1.05, 95% c.i. 1.01 to 1.09), and skin necrosis prevention (RR 1.07, 95% c.i. 1.01 to 1.15). No significant differences were observed for seroma, nipple-areolar complex necrosis, or haematoma. Across outcomes, heterogeneity was substantial and 95% prediction intervals crossed the null, indicating uncertainty in the direction of effect in future settings. Evidence certainty ranged from low to moderate. Cost modelling suggested that iNPWT may be cost-saving only in settings with high SSI-related costs.Conclusions Current evidence does not establish consistent clinical benefit of prophylactic iNPWT in breast surgery. Cost-effectiveness appears limited to high-risk or high-cost contexts, supporting selective use.
   Prophylactic iNPWT may confer modest reductions in selected wound complications after breast surgery, but benefits are inconsistent. Cost-effectiveness appears limited to high-risk or high-cost contexts, supporting selective rather than routine use.
C1 [Kollatos, Christos; Pantiora, Eirini; Eriksson, Staffan; Karakatsanis, Andreas] Uppsala Univ, Dept Surg Sci, Akad Sjukhusvagen Ingang 70, S-75185 Uppsala, Sweden.
   [Kollatos, Christos; Pantiora, Eirini; Karakatsanis, Andreas] Uppsala Univ Hosp, Dept Surg, Sect Breast Surg, Uppsala, Sweden.
   [Sackey, Helena] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Sackey, Helena] Karolinska Univ Hosp, Karolinska Comprehens Canc Ctr, Dept Breast Endocrine Tumors & Sarcoma, Stockholm, Sweden.
   [Pantiora, Eirini] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
   [Vorburger, Denise] Cantonal Hosp Winterthur, Breast Unit, Winterthur, Switzerland.
   [Rocco, Nicola] Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy.
   [Ohrn, Catarina] Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.
   [Ohrn, Catarina] Linkoping Univ Hosp, Dept Surg, Linkoping, Sweden.
   [Valachis, Antonios] Orebro Univ, Fac Med & Hlth, Dept Oncol, Orebro, Sweden.
   [Eriksson, Staffan] Uppsala Univ, Ctr Clin Res Vastmanland, Vasteras, Sweden.
   [Eriksson, Staffan] Vastmanlands Cty Hosp, Dept Surg, Sect Breast Surg, Vasteras, Sweden.
C3 Uppsala University; Uppsala University; Uppsala University Hospital;
   Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital; Karolinska Institutet; University of Naples Federico II;
   Linkoping University; Linkoping University; Orebro University; Uppsala
   University; Vasteras Central Hospital
RP Kollatos, C (通讯作者)，Uppsala Univ, Dept Surg Sci, Akad Sjukhusvagen Ingang 70, S-75185 Uppsala, Sweden.
EM christos.kollatos@uu.se
RI Sackey, Helena/KJU-4264-2024
FU Karolinska Institutet; Erik och Majje Nsstrm
FX Helena Sackey was funded through the Erik och Majje Nasstrom donation to
   Karolinska Institutet.
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NR 59
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD JUN
PY 2026
VL 113
IS 6
AR znag056
DI 10.1093/bjs/znag056
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JD1RS
UT WOS:001786509500001
PM 42084358
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Jreije, S
   Fadel, M
   Karam, C
   Ghadieh, HE
   Ghanem, A
AF Jreije, Sasha
   Fadel, Marwan
   Karam, Carl
   Ghadieh, Hilda E.
   Ghanem, Antoine
TI Diabetes and Delayed Wound Healing: Molecular Mechanisms and
   Dermatological Interventions
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE diabetes mellitus; diabetic ulcers; regenerative medicine; therapeutics;
   wound healing
ID HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED CLOSURE; FOOT ULCERS; LEG
   ULCERS; MATRIX; INTERLEUKIN-1; INFLAMMATION; MANAGEMENT; DRESSINGS;
   EFFICACY
AB Diabetes mellitus is a global burden that affects wound healing at nearly every stage, transforming what should be a coordinated and self-limited repair process into a chronic, non-healing state. In diabetic patients, sustained hyperglycemia drives persistent inflammation, impaired angiogenesis, fibroblast dysfunction and extracellular matrix instability, resulting in refractory ulcers and often causing severe complications such as infection, hospitalisation, amputation and premature death. This review integrates mechanistic insights with dermatological advancements providing a comprehensive picture of diabetic wound pathophysiology and emerging therapeutic approaches. The normal sequence of wound healing is outlined and contrasted with the cellular and molecular derailments seen in diabetes, with a focus on macrophage polarisation, neutrophil dysfunction, mast cell and dendritic cell dysregulation, impaired regulatory T cell function, pericyte loss, disrupted neuroimmunomodulation, oxidative stress and defective tissue remodelling. Current and novel interventions including hyperbaric oxygen therapy, negative pressure wound therapy, advanced dressings, biologic grafts, phototherapy, as well as regenerative strategies involving stem cells, nanomaterials and exosome-based treatments are critically examined for their clinical utility, limitations and translational promise. No single modality fully addresses the multifactorial nature of diabetic wounds, but multimodal, mechanism-driven strategies hold potential to synergistically restore tissue repair. Bridging basic science with innovative dermatological interventions remains essential to reduce the global burden of diabetic wounds and improving quality of life for diabetics.
C1 [Jreije, Sasha; Fadel, Marwan; Karam, Carl; Ghadieh, Hilda E.] Univ Balamand, Fac Med & Med Sci, Dept Biomed Sci, Al Koura, Lebanon.
   [Ghanem, Antoine] St Joseph Univ, Fac Med, Dept Dermatol, Beirut, Lebanon.
   [Ghanem, Antoine] Clemenceau Med Ctr, Dept Dermatol, Dubai, U Arab Emirates.
C3 University Balamand; Saint Joseph University Beirut; American University
   of Beirut
RP Karam, C (通讯作者)，Univ Balamand, Fac Med & Med Sci, Dept Biomed Sci, Al Koura, Lebanon.
EM carl.karam@std.balamand.edu.lb
OI Fadel, Marwan/0009-0002-5880-3423; Karam, Carl/0009-0004-6499-8049
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NR 86
TC 0
Z9 0
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN 8
PY 2026
VL 23
IS 6
AR e70972
DI 10.1111/iwj.70972
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA JD3IF
UT WOS:001786620800001
PM 42253027
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Kazez, M
   Önce, G
   Ayas, O
   Seker, AS
   Kürüm, H
AF Kazez, Muhammed
   Once, Gokhan
   Ayas, Orhan
   Seker, Ali Sami
   Kurum, Huseyin
TI Comparison of negative pressure wound therapy and wet-to-dry dressing
   after fasciotomy in earthquake victims: A retrospective cohort study
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Compartment syndrome; fasciotomy; gradual approximation; negative
   pressure wound therapy; wet-to-dry dressing
ID VACUUM-ASSISTED CLOSURE; LEG
AB BACKGROUND: This study aimed to compare the clinical effectiveness of negative pressure wound therapy (NPWT) with traditional wet-to-dry dressings in patients undergoing fasciotomy for acute compartment syndrome of the lower extremities following the February 6, 2023 earthquakes in Kahramanmara & scedil;, T & uuml;rkiye. METHODS: This retrospective cohort study included 28 patients (15 males, 13 females) admitted to our hospital between February 6 and March 6, 2023, who underwent fasciotomy for lower extremity acute compartment syndrome. A total of 109 fasciotomy incisions were performed across 60 extremities. Of these, 78 wounds were managed with NPWT and 31 with wet-to-dry dressings. Group allocation was determined by NPWT device availability during the disaster period. All patients were managed using a standardized wound closure protocol, including serial debridement followed by primary closure or split-thickness skin grafting when indicated. Outcomes compared between groups included number of debridements, infection rate, primary wound closure, graft requirement, dressing-related complications, and length of hospital stay. RESULTS: The NPWT group required significantly fewer debridements (p<0.05). Dressing-related complications and the need for additional dressing interventions were significantly higher in the wet-to-dry group (p<0.05). No significant differences were observed between groups in infection rate, primary wound closure, graft requirement, or length of hospital stay (p>0.05). Among pediatric patients, infection rates were lower than in adults, whereas unplanned dressing changes were significantly more frequent (p<0.05). CONCLUSION: NPWT is an effective wound management modality in fasciotomy patients, even under disaster conditions. It significantly reduced the need for debridement and dressing-related complications compared to traditional methods, despite similar outcomes in infection and wound closure. These findings support the preferential use of NPWT in mass-casualty settings, where healthcare personnel and resources may be limited. In addition to its clinical benefits, NPWT offers logistical advantages by simplifying wound care and reducing healthcare workload. Future prospective, randomized, multicenter studies are needed to confirm these findings and evaluate the broader applicability and cost-effectiveness of NPWT in both disaster and routine clinical settings.
C1 [Kazez, Muhammed; Once, Gokhan; Ayas, Orhan; Seker, Ali Sami; Kurum, Huseyin] Elazig Fethi Sekin City Hosp, Dept Orthoped & Traumatol, Elazig, Turkiye.
RP Kazez, M (通讯作者)，Elazig Fethi Sekin City Hosp, Dept Orthoped & Traumatol, Elazig, Turkiye.
EM mkzz23@hotmail.com
CR Abu-Zidan FM, 2024, TURK J EMERG MED, V24, P67, DOI 10.4103/tjem.tjem_11_24
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NR 24
TC 0
Z9 0
U1 3
U2 3
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, Turkiye
SN 1306-696X
EI 1307-7945
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD JUN
PY 2026
VL 32
IS 6
BP 745
EP 753
DI 10.14744/tjtes.2025.20250
PG 9
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA JD4QV
UT WOS:001786710800015
PM 42261853
OA Green Submitted, Bronze
DA 2026-07-24
ER
PT J
AU Zhao, YA
   Frei, F
   Kalbas, Y
   Pape, HC
   Jukema, GN
AF Zhao, Yina
   Frei, Flurina
   Kalbas, Yannik
   Pape, Hans-Christoph
   Jukema, Gerrolt N.
TI Long term experiences with negative pressure wound therapy in
   combination with polyhexanid solution instillation technique for
   treatment of posttraumatic infections and osteomyelitis
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Negative pressure polyhexanid
   instillation technique; posttraumatic osteomyelitis; posttraumatic
   infection
ID ANTISEPTIC SOLUTION; PSEUDOMONAS-PUTIDA; PROTEUS; IMPACT; SALINE; FOAM
AB Purpose This retrospective study assessed the effectiveness of Negative Pressure Wound Therapy with Instillation using polyhexanide 0.2% solution for treating infected chronic trauma-related wounds, open fractures, and posttraumatic osteomyelitis. Methods A total of 67 patients (2014-2024) were categorized into posttraumatic osteomyelitis (N = 27), open fractures (N = 23), and soft tissue infections/trauma wounds (N = 17). The therapy combined surgical debridement and vacuum-assisted dressing with intermittent polyhexanide 0.2% instillation. Foam dressings were changed every 3-4 days, with concurrent antibiotic therapy. Results Statistical analysis showed significant reductions in bacterial specimens (99 to 20, p < 0.001), and a low reinfection of 10.2% in osteomyelitis and open fracture, which is lower compared to standard treatments (debridement, lavage and antibiotic loaded beads). The average treatment was 12.6 days with 3.22 dressing changes, with variations between the groups. CRP (C-reactive protein) levels significantly decreased from start to follow-up (p = 0.014). Over half of the cases achieved delayed primary closure, with osteomyelitis showing a longer duration of antibiotic therapy compared to the other groups. The most common risk factors were cardiovascular conditions, with an average of 3.17 risk factors per patient. Conclusion While limited by its retrospective design and small sample size, this study provides a basis to hypothesize that Negative Pressure Wound Therapy with Instillation can be an effective adjunctive method in reducing bacterial load, may accelerate wound closure and lower infection recurrence, particularly for osteomyelitis and orthopaedic implant infections.
C1 [Zhao, Yina; Frei, Flurina; Kalbas, Yannik; Pape, Hans-Christoph; Jukema, Gerrolt N.] Univ Hosp Zurich, Dept Traumatol, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Zhao, YA (通讯作者)，Univ Hosp Zurich, Dept Traumatol, Zurich, Switzerland.
EM yina.zhao@usz.ch
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   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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NR 34
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD APR 25
PY 2026
VL 411
IS 1
AR 158
DI 10.1007/s00423-026-04061-y
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JF8FT
UT WOS:001788310100002
PM 42034684
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Yalin, M
   Kazez, M
AF Yalin, Mustafa
   Kazez, Muhammed
TI Long-term recovery after fasciotomy for earthquake-related acute
   compartment syndrome: a comparative study of pediatric and adult
   patients
SO BMC SURGERY
LA English
DT Article
DE Fasciotomy; Acute Compartment Syndrome; Delayed Primary Closure;
   Earthquake; Skin Grafting
ID WOUND CLOSURE; CHILDREN DIAGNOSIS; EXTREMITY; LEG; MANAGEMENT; OUTCOMES;
   INJURY
AB Background Age-related differences after fasciotomy for earthquake-related acute compartment syndrome (ACS) remain incompletely defined. This study compared pediatric and adult patients with respect to definitive wound closure, baseline injury characteristics, wound-course complexity, and 12-month recovery. Methods This retrospective comparative cohort included 29 patients who underwent fasciotomy for earthquake-related ACS (9 pediatric, 20 adult). Baseline variables included time under rubble, time to hospital admission, number of fasciotomy incisions, affected extremity distribution, associated fracture, associated vascular injury, Injury Severity Score (ISS), and vacuum-assisted closure (VAC) duration. Wound-course variables included delayed primary closure (DPC), split-thickness skin grafting (SG), re-debridement count, wound infection, graft failure, and revision surgery. Long-term recovery was assessed at 6 and 12 months using full muscle strength, full joint range of motion (ROM), and joint stiffness. Unfavorable 12-month recovery was defined as failure to regain full ROM and/or full muscle strength, or persistence of clinically relevant stiffness. Results Time under rubble was comparable between pediatric and adult patients (16.7 +/- 11.3 vs. 14.8 +/- 7.8 h, p = 0.92), whereas time to hospital admission was longer in pediatric patients (65.5 +/- 29.5 vs. 40.1 +/- 15.6 h, p = 0.01). DPC was achieved in 88.9% versus 10.0% (p < 0.001), while SG was required in 11.1% versus 90.0% (p < 0.001). VAC duration was shorter in pediatric patients (12.4 +/- 2.3 vs. 22.6 +/- 8.2 days, p < 0.001), and re-debridement count was lower (0.7 +/- 0.5 vs. 2.1 +/- 1.0, p = 0.002). At 6 months, full muscle strength (88.9% vs. 45.0%, p = 0.043) and full ROM (77.8% vs. 35.0%, p = 0.050) favored the pediatric group. At 12 months, full ROM remained numerically higher in pediatric patients (77.8% vs. 50.0%, p = 0.23), while unfavorable 12-month recovery occurred in 11.1% versus 50.0% (p = 0.096). In exploratory multivariable analysis, SG, re-debridement count, and 6-month stiffness were associated with unfavorable recovery, whereas pediatric age group was protective. Associated fracture and ISS were not independently associated with unfavorable 12-month recovery. Conclusion Pediatric patients showed more favorable definitive closure profiles and less complex wound courses despite later presentation. They also showed signals of more favorable longer-term recovery, although between-group differences in 12-month functional outcomes did not reach conventional statistical significance. Wound-course factors and, to a lesser extent, baseline injury burden may partly explain age-related differences in recovery after fasciotomy for earthquake-related ACS.
C1 [Yalin, Mustafa] Yalova Univ, Fac Med, Dept Orthoped & Traumatol, TR-77200 Yalova, Turkiye.
   [Kazez, Muhammed] Elazig Fethi Sekin City Hosp, Dept Orthoped & Traumatol, Elazig, Turkiye.
C3 Yalova University
RP Yalin, M (通讯作者)，Yalova Univ, Fac Med, Dept Orthoped & Traumatol, TR-77200 Yalova, Turkiye.
EM mustiyalin1988@gmail.com; mkzz23@hotmail.com
RI yalın, mustafa/JOJ-5214-2023
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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NR 31
TC 0
Z9 0
U1 3
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD APR 28
PY 2026
VL 26
IS 1
AR 409
DI 10.1186/s12893-026-03800-8
EA APR 2026
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JL5KU
UT WOS:001792188900002
PM 42050551
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Xing, YH
   Lv, R
   Xie, C
   Cao, WJ
   Dou, JY
   Jiang, XC
   Wang, WF
   Wang, ZY
   Ding, ZG
   Qiu, XL
   Tang, L
AF Xing, Yihui
   Lv, Ran
   Xie, Chen
   Cao, Wenjuan
   Dou, Jiayi
   Jiang, Xiaochen
   Wang, Weifeng
   Wang, Ziyang
   Ding, Zhiguo
   Qiu, Xueling
   Tang, Lu
TI Premixed nitrous oxide/oxygen analgesia for removal of vacuum assisted
   closure dressing: a randomized, double-blinded placebo-controlled trial
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Nitrous oxide; Analgesia; Vacuum assisted closure; Procedure pain
ID PRESSURE WOUND THERAPY; OPEN FRACTURES; OXIDE; PAIN; SEDATION; IMPACT;
   PATIENT; ANESTHESIOLOGY; GUIDELINES; ENTONOX(R)
AB Vacuum assisted closure (VAC) is commonly used in clinical practice to promote wound healing. During the dressing removal of VAC, patients may suffer from different degrees of pain, or even discontinue treatment due to severe pain. Our study sought to determine whether or not nitrous oxide analgesia decreases pain compared to oxygen placebo during removal of VAC dressing. This study is a double-blind, placebo-controlled randomized trial targeting patients who underwent replacement of VAC dressings in orthopedics. All patients were randomized in a 1:1 ratio to receive 65% premixed nitrous oxide/oxygen versus 100% oxygen. The primary outcome was the intensity of pain during the intervention. Secondary outcomes included adverse effects, satisfaction of patients, and physiological parameters (blood pressure, heart rate, oxygen saturation). Between 18 February, 2022 and 9 May, 2023, 114 participants were enrolled, 57 patients were allocated to the intervention group (premixed nitrous oxide/oxygen), 57 patients were enrolled in the control group (oxygen). The baseline and procedural characteristics were comparable between the two groups. The pain score reported by patients immediately after removing the dressing in the intervention group was significantly lower than that in the control group (median 3.0 vs. 6.3, P < 0.001). The satisfaction of patients in the intervention group significantly increased (Z=-6.861, P < 0.001). There were no significant differences in vital signs, operation duration, and adverse reactions between the two groups. Premixed nitrous oxide/oxygen can reduce the pain caused by removal VAC dressing in patients and can be considered an effective analgesic measure.
C1 [Xing, Yihui; Cao, Wenjuan; Dou, Jiayi; Jiang, Xiaochen; Wang, Weifeng; Wang, Ziyang; Qiu, Xueling; Tang, Lu] 960th Hosp Peoples Liberat Army China PLA, Dept Stomatol, Jinan 250031, Peoples R China.
   [Xing, Yihui] Qingdao Stomatlolg Hosp, Qingdao, Peoples R China.
   [Lv, Ran] Shandong Univ, Sch Nursing & Rehabil, Jinan, Peoples R China.
   [Xie, Chen] 960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
   [Cao, Wenjuan; Dou, Jiayi; Jiang, Xiaochen; Wang, Weifeng; Wang, Ziyang] Shandong Second Med Univ, Sch Nursing, Weifang, Peoples R China.
   [Ding, Zhiguo] Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao, Peoples R China.
C3 Shandong University; Shandong Second Medical University; Qingdao
   Municipal Hospital
RP Tang, L (通讯作者)，960th Hosp Peoples Liberat Army China PLA, Dept Stomatol, Jinan 250031, Peoples R China.
EM tanglu_office@163.com
FU clinical medical science and technology innovation project of Jinan
   [202019025]
FX This study was supported by clinical medical science and technology
   innovation project of Jinan (Grant number: 202019025).
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NR 59
TC 0
Z9 0
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 21
PY 2026
VL 16
IS 1
AR 18409
DI 10.1038/s41598-026-46571-1
EA APR 2026
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JM5TA
UT WOS:001792890100003
PM 42009792
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Lin, ZJ
   Chen, ZJ
   Hu, YC
   Weng, DY
   Huang, JF
   Lin, DN
   Lin, DY
AF Lin, Zhengjie
   Chen, Zhijing
   Hu, Yangcheng
   Weng, Danyi
   Huang, Jianfeng
   Lin, Dane
   Lin, Danyi
TI Integrated Management of Mycobacterium abscessus Infections Following
   Aesthetic Fat Grafting: A Promising Combination of Targeted Medication
   and Minimally Invasive Surgery
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article; Early Access
DE Autologous fat filling; Mycobacterium abscessus; Infected wound; Anti-TB
   drugs
ID DIAGNOSIS; SKIN
AB BackgroundInfections caused by nontuberculous mycobacteria (NTM), particularly Mycobacterium abscessus, represent rare but increasingly reported complications following cosmetic fat transplantation. However, standardized and effective treatment protocols remain underexplored. This study aimed to evaluate the efficacy of anti-tuberculosis (anti-TB) medication combined with local vacuum aspiration in treating multiple wound infections caused by Mycobacterium abscessus complex following autologous fat transplantation.MethodsBetween June 2017 and June 2019, 10 patients with M. abscessus complex infection after autologous fat grafting were enrolled, involving a total of 70 infected wounds (31 facial, 32 breast, and 7 thigh sites). Prior to minimal-incision open debridement, ultrasound localization was performed. Necrotic granulation tissue was thoroughly curetted, followed by vacuum sealing drainage (VSD) with continuous aspiration. Irrigation and drainage tubes were subsequently placed to promote granulation tissue formation. All patients received standardized anti-TB drug therapy.ResultsDuring a follow-up period ranging from 8 to 16 months (mean: 12 months), all 70 wounds in the 10 enrolled patients achieved satisfactory healing in terms of both deep tissue repair and superficial appearance. No recurrence of infection was observed throughout the follow-up period. Wound closure was accomplished without the need for additional surgical reconstruction in all cases. The combination of anti-TB chemotherapy and vacuum aspiration consistently promoted granulation tissue formation and controlled local inflammation, leading to functionally and cosmetically acceptable outcomes across all anatomical sites, including face, breast, and thigh regions.ConclusionThe combination of minimal-incision debridement, local vacuum aspiration, and anti-TB medication provides an effective and practical treatment for M. abscessus infections secondary to autologous fat grafting. This integrated approach is recommended for managing such challenging postoperative infections.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
C1 [Lin, Zhengjie; Lin, Danyi] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pathol, Guangzhou 510080, Peoples R China.
   [Lin, Zhengjie] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Endocrinol & Metab, Hengyang 421001, Peoples R China.
   [Chen, Zhijing] Shantou Univ, Affiliated Hosp 1, Dept Med Cosmet Ctr, Med Coll, Shantou 515041, Peoples R China.
   [Hu, Yangcheng] Shantou Cent Hosp, Dept Urol, Shantou 515031, Peoples R China.
   [Weng, Danyi] Shantou Chaonan Minsheng Hosp, Dept Nephrol, Shantou 515144, Peoples R China.
   [Huang, Jianfeng] Shantou Univ, Affiliated Hosp 1, Dept Pediat, Med Coll, Shantou 515041, Peoples R China.
   [Lin, Dane] Shantou Univ, Affiliated Hosp 1, Dept Neonatal Intens Care Unit, Dept Pediat,Med Coll, Shantou 515041, Peoples R China.
C3 Southern Medical University - China; Guangdong Academy of Medical
   Sciences & Guangdong General Hospital; University of South China;
   Shantou University; Shantou University; Shantou University
RP Lin, DY (通讯作者)，Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pathol, Guangzhou 510080, Peoples R China.; Huang, JF (通讯作者)，Shantou Univ, Affiliated Hosp 1, Dept Pediat, Med Coll, Shantou 515041, Peoples R China.; Lin, DN (通讯作者)，Shantou Univ, Affiliated Hosp 1, Dept Neonatal Intens Care Unit, Dept Pediat,Med Coll, Shantou 515041, Peoples R China.
EM 1076101404@qq.com; m13715870419@163.com; danyi_l@126.com
FU Guangdong Provincial Administration of Traditional Chinese Medicine
   Project [20251008]
FX This study was supported by Guangdong Provincial Administration of
   Traditional Chinese Medicine Project (No.20251008).
CR Baldwin SL, 2019, PLOS NEGLECT TROP D, V13, DOI 10.1371/journal.pntd.0007083
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD 2026 JUN 15
PY 2026
DI 10.1007/s00266-026-05961-6
EA JUN 2026
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JN1SP
UT WOS:001793294600001
PM 42298160
DA 2026-07-24
ER
PT J
AU Tsutsumi, K
   Yamanaka, N
   Tokioka, M
   Ishida, O
AF Tsutsumi, Koji
   Yamanaka, Nozomi
   Tokioka, Misato
   Ishida, Osamu
TI The Effect of Closed Incision Negative Original Pressure Wound Therapy
   for Prophylactic Article Use of Postoperative Deep Sternal Wound
   Infection in Patients Following Coronary Artery Bypass Grafting: A
   Single-Institutional Study
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE negative pressure wound therapy; sternal wound infection; prevention
AB Purpose: The aim of this study was to evaluate the effectiveness of closed-incision negative pressure wound therapy (ciNPWT) as a prophylactic measure to prevent deep sternal wound infection (DSWI) after surgery. Methods: A total of 209 patients undergoing isolated coronary artery bypass grafting via median sternotomy were enrolled. The patients were divided into 3 groups according to incisional care. In Group A (n = 63), the wound was covered with sterile gauze dressings alone. In Group B (n = 71), an indwelling subcutaneous drain was placed and the wound was covered with a hydrocolloid dressing. In Group C (n = 75), an indwelling subcutaneous drain was placed and the wound was covered with a ciNPWT device (PICO; Smith & Nephew). The incidence of DSWI occurring within 60 postoperative days was compared among the 3 groups. Results: There were no significant differences in preoperative, operative, or postoperative variables among the groups. Postoperative DSWI occurred in 11.1% (7/63) of patients in Group A and 5.6% (4/71) of patients in Group B, whereas no patients in Group C developed DSWI. Conclusions: Immediate application of NPWT was associated with a reduced rate of wound infection. This treatment may represent an effective preventive strategy.
C1 [Tsutsumi, Koji; Yamanaka, Nozomi; Tokioka, Misato; Ishida, Osamu] Natl Def Med Coll, Dept Cardiovasc Surg, 3-2 Namiki, Tokorozawa, Saitama, Japan.
C3 National Defense Medical College - Japan
RP Tsutsumi, K (通讯作者)，Natl Def Med Coll, Dept Cardiovasc Surg, 3-2 Namiki, Tokorozawa, Saitama, Japan.
EM con318@ndmc.ac.jp
RI Ishida, Osamu/GRJ-5887-2022
CR Chen DS, 2024, INT WOUND J, V21, DOI 10.1111/iwj.14457
   de Tymowski C, 2025, SURGERY, V181, DOI 10.1016/j.surg.2025.109255
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
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   Rupprecht Leopold, 2013, Open J Cardiovasc Surg, V6, P9, DOI 10.4137/OJCS.S11199
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   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
NR 10
TC 0
Z9 0
U1 0
U2 0
PU Annals Thoracic and Cardiovascular Surgery Editorial Office
PI Tokyo
PA International Academic Publishing Co., Ltd, c/o Publishing Center,
   Yamabuki-cho 332-6, Tokyo, Shinjuku-ku, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2026
VL 32
IS 1
AR 2600048
DI 10.5761/atcs.oa.26-00048
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA JN5TS
UT WOS:001793569600001
PM 42289342
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Qu, XY
   Liu, GH
   Wei, WS
   Zhang, YH
   Li, KM
   Wang, XOJ
   Lang, XY
   Jiang, K
AF Qu, Xiaoyan
   Liu, Gaohua
   Wei, Wensheng
   Zhang, Yahui
   Li, Keming
   Wang, Xaiojun
   Lang, Xianyun
   Jiang, Kai
TI Staged Comprehensive Management for Necrotizing Fasciitis of the Lower
   Extremity with Sepsis: A Case Report
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID EARLY-DIAGNOSIS; SCORE
AB Necrotizing fasciitis is a severe soft tissue infection characterized by rapid necrosis of the skin, subcutaneous tissue, and fascia. Its onset is sudden, and progress is rapid. Complications such as sepsis, septic shock, and multiple organ dysfunction syndrome (MODS) can appear early, leading to high mortality and disability. The early symptoms lack specificity, posing diagnostic challenges and a high risk of misdiagnosis. This case report describes a 37-year-old male patient who presented with progressive redness, swelling, and pain of the left lower limb. Bedside incision and exploration under local anesthesia confirmed acute necrotizing fasciitis. Staged comprehensive management included early surgical debridement, empirical antibiotics, anti-shock therapy, vacuum sealing drainage, and eventual skin grafting. The patient's limb was salvaged, and at 1-year follow-up, he had returned to normal daily activities. This case may provide limited insights for the clinical management of similar patients, particularly regarding the importance of timely bedside exploration and a multidisciplinary, staged approach.
C1 [Qu, Xiaoyan; Liu, Gaohua; Wei, Wensheng; Zhang, Yahui; Li, Keming; Wang, Xaiojun; Lang, Xianyun; Jiang, Kai] 971 Hosp Peoples Liberat Army Navy, Dept Hand Surg, Qingdao, Shandong, Peoples R China.
RP Jiang, K (通讯作者)，971 Hosp Peoples Liberat Army Navy, Dept Hand Surg, Qingdao, Shandong, Peoples R China.
EM swkebq_971yy@163.com
FU Military Clinical Specialty Development and Cultivation Fund [2024]
FX Funding: Military Clinical Specialty Development and Cultivation Fund
   (2024) .
CR Bonne SL, 2017, INFECT DIS CLIN N AM, V31, P497, DOI 10.1016/j.idc.2017.05.011
   Bucca K, 2013, ANZ J SURG, V83, P365, DOI 10.1111/j.1445-2197.2012.06251.x
   Burn Surgery Branch of the Chinese Medical Association Editorial Board of the Chinese Journal of Burns, 2017, CHIN J BURNS, V33, P129
   Cheng NC, 2015, BMC INFECT DIS, V15, DOI 10.1186/s12879-015-1144-0
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   Li Longzhu, 2015, Zhonghua Shao Shang Za Zhi, V31, P98
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   Morgan MS, 2010, J HOSP INFECT, V75, P249, DOI 10.1016/j.jhin.2010.01.028
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   Salati SA, 2024, POL J SURG, V95, DOI 10.5604/01.3001.0015.8571
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD JUN
PY 2026
IS 232
AR e69669
DI 10.3791/69669
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JO6BI
UT WOS:001794269200009
PM 42329972
DA 2026-07-24
ER
PT J
AU Mirza, W
   Khan, ME
   Iqbal, H
   Khan, A
   Khan, HM
   Moeen-Ud-Din, MB
   Hadhoud, AM
AF Mirza, Wajahat
   Khan, Mehak Ejaz
   Iqbal, Hania
   Khan, Alishbah
   Khan, Hadi Mohammad
   Moeen-Ud-Din, Muhammad Bilal
   Hadhoud, Abdalla M.
TI Negative-pressure wound therapy versus conventional dressings following
   stoma reversal: a GRADE-based systematic review and meta-analysis of
   randomized controlled trials with predefined subgroup analyses by
   closure technique
SO BMC SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; Stoma reversal; Surgical site
   infection; Ileostomy closure; Colostomy closure; Wound healing;
   Meta-analysis; Randomized controlled trial; Purse-string closure; Linear
   primary closure
ID PREVENTION
AB BackgroundSurgical site infection (SSI) after stoma reversal remains common (15-40%), prolonging hospitalization and potentially delaying adjuvant therapy. Prophylactic negative-pressure wound therapy (NPWT) is increasingly used for closed incisions; however, its efficacy with different skin-closure techniques remains unclear. We conducted a systematic review and meta-analysis of randomized controlled trials comparing NPWT with conventional non-pressure dressings after stoma reversal, with prespecified subgroup analyses by skin-closure technique and certainty of evidence appraised using GRADE.MethodsThe review protocol was registered in the PROSPERO International Prospective Register of Systematic Reviews (CRD420251182767). We searched MEDLINE, Embase, Scopus, Web of Science, CENTRAL, ClinicalTrials.gov, and WHO ICTRP without language restrictions. Eligible randomized controlled trials enrolled adults undergoing elective ileostomy or colostomy reversal and compared negative-pressure wound therapy (NPWT) with conventional (non-pressure) dressings with a specified skin-closure technique (purse-string or primary). The primary outcome was incisional surgical site infection within 30-42 days of surgery. Secondary outcomes included length of stay, time to complete wound healing, operative duration, and estimated blood loss. Two reviewers independently screened the studies, extracted data, and assessed the risk of bias using RoB 2. Random-effects meta-analyses were conducted with sensitivity analyses and pre-specified subgroup comparisons based on closure techniques. The certainty of evidence was appraised using GRADE.ResultsSeven randomized trials (n = 429) met the inclusion criteria (NPWT, n = 220; conventional dressings, n = 209). The primary pooled analysis showed no significant reduction in incisional SSI with NPWT versus conventional dressings (RR 0.42, 95% CI 0.14-1.30; I & sup2;=46%). By closure technique, the effects were larger with primary closure (RR 0.20, 95% CI 0.06-0.67; I & sup2;=0%) than with purse-string closure (RR 0.68, 95% CI 0.14-3.35; I & sup2;=48%), although the interaction was not statistically significant (P = 0.23). The risk of bias was generally rated as "some concerns," primarily due to open-label care, and heterogeneity was low after the sensitivity analysis.Prespecified leave-one-out analyses identified influential studies for SSI, length of stay, and wound healing; however, these findings were interpreted as exploratory influence diagnostics and did not replace the primary pooled analyses.ResultsSeven randomized trials (n = 429) met the inclusion criteria (NPWT, n = 220; conventional dressings, n = 209). The primary pooled analysis showed no significant reduction in incisional SSI with NPWT versus conventional dressings (RR 0.42, 95% CI 0.14-1.30; I & sup2;=46%). By closure technique, the effects were larger with primary closure (RR 0.20, 95% CI 0.06-0.67; I & sup2;=0%) than with purse-string closure (RR 0.68, 95% CI 0.14-3.35; I & sup2;=48%), although the interaction was not statistically significant (P = 0.23). The risk of bias was generally rated as "some concerns," primarily due to open-label care, and heterogeneity was low after the sensitivity analysis.Prespecified leave-one-out analyses identified influential studies for SSI, length of stay, and wound healing; however, these findings were interpreted as exploratory influence diagnostics and did not replace the primary pooled analyses.
   ConclusionsIn this primary pooled analysis, prophylactic NPWT did not significantly reduce incisional surgical site infection after stoma reversal, although the effect favored NPWT. Exploratory sensitivity and subgroup analyses suggested possible benefits in selected contexts, although these findings should not supersede the nonsignificant primary pooled analyses. Larger, standardized randomized trials are needed to clarify which closure techniques and patient groups derive the greatest benefit.
C1 [Mirza, Wajahat] Shifa Tameer e Millat Univ, Shifa Coll Med, Sect H 8-4, Islamabad, Pakistan.
   [Khan, Mehak Ejaz; Iqbal, Hania; Khan, Alishbah] Shifa Int Hosp, Resident Gen Surg, Islamabad, Pakistan.
   [Khan, Hadi Mohammad] Shifa Int Hosp, Dept Gen Surg & Surg Oncol, Islamabad, Pakistan.
   [Moeen-Ud-Din, Muhammad Bilal; Hadhoud, Abdalla M.] Univ Cincinnati, Dept Surg, Cincinnati, OH USA.
C3 Shifa College of Medicine; University System of Ohio; University of
   Cincinnati
RP Mirza, W (通讯作者)，Shifa Tameer e Millat Univ, Shifa Coll Med, Sect H 8-4, Islamabad, Pakistan.
EM wajahatmirza.clinicalresearch@gmail.com; mehak.ejazz@gmail.com;
   haniaiqbal000@gmail.com; alishkhan43@gmail.com; hadi.khan786@gmail.com;
   moeenumd@ucmail.uc.edu; hadhouam@ucmail.uc.edu
FX No external funding was received for this systematic review and
   meta-analysis.
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD JUN 19
PY 2026
VL 26
IS 1
AR 421
DI 10.1186/s12893-026-03957-2
EA JUN 2026
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JT2IN
UT WOS:001797407200001
PM 42316134
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Yoshida, S
   Ishida, O
   Tsutsumi, K
AF Yoshida, S.
   Ishida, O.
   Tsutsumi, K.
TI Prophylactic closed-incision negative pressure wound therapy after
   median sternotomy: a scoping review of surgical site infection
   prevention bundle reporting and implication for interpretation
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Review
DE Cardiac surgical procedures; Negative pressure wound therapy;
   Postoperative complications; Surgical site infection; Wound healing
ID MANAGEMENT-SYSTEM; ASSOCIATION; STATEMENT
AB Background: Closed-incision negative pressure wound therapy (ciNPT) is increasingly used to reduce surgical site infection (SSI) after median sternotomy, yet its true preventive effect remains uncertain. Published studies rarely specify which infection prevention measures were used alongside the therapy, making interpretation difficult. Aim: In this scoping review, we examined the completeness of reporting of infection prevention practices in studies evaluating ciNPT after cardiac surgery. Methods: A systematic search of PubMed, Scopus, and the Cochrane Library identified studies of adult cardiac surgery in which negative pressure therapy was applied prophylactically to the closed sternal incision. Information on study design, patient characteristics, therapy protocols, clinical outcomes, and reporting of infection prevention elements was extracted. Reporting was classified as complete, partial, or absent according to 13 components derived from major clinical guidelines. Findings: Twenty-five studies met the inclusion criteria. Most studies reported fewer SSIs in patients receiving negative pressure therapy, but none described a complete set of infection prevention measures. Eighty-seven percent of recommended elements were not reported, and selective use of the therapy introduced additional bias. Conclusion: The substantial absence of infection prevention reporting limits the interpretability and reproducibility of current evidence. Standardized and transparent documentation is required to better define the preventive value of ciNPT. (c) 2026 The Author(s). Published by Elsevier Ltd on behalf of The Healthcare Infection Society. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Yoshida, S.; Ishida, O.; Tsutsumi, K.] Natl Def Med Coll, Dept Cardiovasc Surg, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
C3 National Defense Medical College - Japan
RP Ishida, O (通讯作者)，Natl Def Med Coll, Dept Cardiovasc Surg, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM oishida2000@gmail.com
RI Ishida, Osamu/GRJ-5887-2022
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NR 44
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD JUL
PY 2026
VL 173
BP 230
EP 239
DI 10.1016/j.jhin.2026.05.020
EA JUN 2026
PG 10
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA JU3NB
UT WOS:001798164700001
PM 42167605
OA hybrid
DA 2026-07-24
ER
PT J
AU Islam, I
   Dey, P
   Thalluri, C
AF Islam, Injamul
   Dey, Piyali
   Thalluri, Chandrashekar
TI Therapeutic strategies to enhance proliferation in diabetic wound
   contraction: a comprehensive review from 1991-2025
SO ACTA DIABETOLOGICA
LA English
DT Review; Early Access
DE Diabetic wound; Wound contraction; Modern technology; Complimentary
   approach; Proliferation; Experimental model
ID HYPERBARIC-OXYGEN THERAPY; GROWTH-FACTOR; FOOT ULCERS; MYOFIBROBLAST;
   FORMULATIONS; MEMBRANES; DELIVERY; PHASE
AB The global rise in diabetes mellitus has been accompanied by a marked increase in associated complications, most notably impaired wound healing. Diabetic non-healing wounds arise from multifactorial pathophysiological mechanisms, including excessive and prolonged inflammation, immune dysregulation, impaired angiogenesis, defective fibroblast-to-myofibroblast transition and aberrant growth factor signaling. These abnormalities delay wound contraction and re-epithelialization, increasing susceptibility to infection, chronic ulceration and limb amputation. Traditional and complementary approaches such as herbal formulations, Ayurvedic practices, and natural bioactive compounds have demonstrated potential in mitigating oxidative stress, modulating inflammation and promoting neovascularization. In parallel, advanced technological interventions, including nanocomposite hydrogels, smart and responsive biomaterials, gene therapy and targeted growth factor delivery systems, are being developed to create a pro-regenerative wound microenvironment. Modern clinical strategies such as electromagnetic therapy, negative pressure wound therapy, electrospun nanofiber scaffolds and 3D/4D bioprinting further contribute to enhanced wound contraction and tissue regeneration. Additionally, bioengineered skin substitutes, stem cell-based therapies and innovative growth factor delivery platforms offer promising translational prospects. This review critically summarizes traditional, complementary, and innovative approaches reported up to 2025, with an emphasis on smart biomaterials, emerging therapies and relevant preclinical models, highlighting future directions for improving diabetic wound care and patient quality of life.Graphical abstractIllustration of impaired wound healing under diabetic conditions and the coordinated contribution of complementary and advanced therapeutic strategies to enhance wound contraction. Diabetes-associated oxidative stress, chronic inflammation and growth factor dysregulation delay tissue repair, whereas smart biomaterials, growth factor-based therapies, nanotherapeutics, bioprinting, exosome-loaded systems and adjunct physical therapies promote angiogenesis, extracellular matrix remodeling, re-epithelialization and accelerated wound closure.
C1 [Islam, Injamul; Dey, Piyali; Thalluri, Chandrashekar] Assam Town Univ, Fac Pharmaceut Sci, Gauhati 781026, Assam, India.
RP Dey, P (通讯作者)，Assam Town Univ, Fac Pharmaceut Sci, Gauhati 781026, Assam, India.
EM piyali.drl@gmail.com
RI Shekar, Chandra/LKK-6483-2024
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NR 143
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD 2026 JUN 23
PY 2026
DI 10.1007/s00592-026-02728-y
EA JUN 2026
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JX0XL
UT WOS:001800026800001
PM 42334597
DA 2026-07-24
ER
PT J
AU Travers, HI
   Kuznetsov, M
   Mazzocco, J
   Pagani, N
   Ide, T
   Hollenbeck, BL
   Smith, EL
AF Travers, Hannah I.
   Kuznetsov, Mikhail
   Mazzocco, John
   Pagani, Nicholas
   Ide, Tricia
   Hollenbeck, Brian L.
   Smith, Eric L.
TI Musculoskeletal Quality Collaborative Improves Value-Based Health Care
   Delivery Across Hospital System
SO AMERICAN JOURNAL OF MANAGED CARE
LA English
DT Article
ID PRESSURE WOUND THERAPY; KNEE ARTHROPLASTY; TOTAL HIP; INFECTION;
   OUTCOMES
AB Objectives: Rising health care costs necessitate value-based health care (VBHC) initiatives. Large hospital systems offer a platform for surgeon collaboration in developing standardized, interdisciplinary orthopedic care. This study evaluates the formation, implementation, and outcomes of the Musculoskeletal Quality Collaborative (MSKQC) across a hospital system. Methods: Established in 2019, the MSKQC comprises physician, quality, and nursing leaders from 14 hospitals. Using the Delphi method, surgeons identified VBHC interventions, leading to protocols for antibiotic-infused bone cement (AIBC), povidone-iodine irrigation, and negative pressure wound therapy (NPWT) dressings, implemented in May 2023. Usage was tracked across hospitals and reviewed quarterly from June 2023 to June 2024. Total hip arthroplasty and total knee arthroplasty (TKA) standardized infection ratios (SIRs) were calculated using National Healthcare Safety Network (NHSN) baselines. Surgeons performing more than 30 cases annually with more than 30% utilization of a target consumable were deemed high utilizers. Results: The systemwide savings opportunity exceeded $800,000 annually. AIBC use dropped from 19.6% to 5.5%. Two high-use hospitals showed gradual improvement, and 7 high-use surgeons were identified. NPWT usage remained stable at less than 5%. Sterile iodine irrigation decreased by 51.6% to less than 10%. TKA infections occurred in 18 of 6592 (0.27%) surgeries in 2023, compared with 14 of 5955 (0.24%) in 2022. The NHSN SIR was 0.906. Conclusions: The MSKQC successfully reduced high-cost consumable use while maintaining low infection rates. Regular protocol distribution and surgeon-specific feedback proved effective in advancing VBHC initiatives. This model offers a scalable approach for orthopedic VBHC implementation in the absence of national guidelines.
C1 [Travers, Hannah I.; Kuznetsov, Mikhail; Pagani, Nicholas; Ide, Tricia; Hollenbeck, Brian L.; Smith, Eric L.] New England Baptist Hosp, 125 Parker Hill Ave, Boston, MA 02120 USA.
   [Mazzocco, John] Tufts Med Ctr, Boston, MA USA.
C3 New England Baptist Hospital; Tufts Medical Center
RP Travers, HI (通讯作者)，New England Baptist Hosp, 125 Parker Hill Ave, Boston, MA 02120 USA.
EM htravers@nebh.org
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NR 33
TC 0
Z9 0
U1 0
U2 0
PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC
PI PLAINSBORO
PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA
SN 1088-0224
J9 AM J MANAG CARE
JI Am. J. Manag. Care
PD JUN
PY 2026
VL 32
IS 6
SI SI
BP SP269
EP SP275
PG 7
WC Health Care Sciences & Services; Health Policy & Services; Medicine,
   General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA JY8AU
UT WOS:001801185300001
PM 42258248
DA 2026-07-24
ER
PT J
AU Lee, JH
   Kim, IK
   Kim, SE
AF Lee, Joon-Hyuk
   Kim, Il-Kug
   Kim, Sung-Eun
TI Perioperative Challenges in Oral Cavity Cancer Reconstruction in a
   Patient with Behçet's Disease: A Case Report
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE Beh & ccedil;et's disease; oral squamous cell carcinoma; floor-of-mouth
   cancer; anterolateral thigh free flap; pectoralis major myocutaneous
   flap; wound dehiscence; pathergy; vasculitis; fistula; head and neck
   reconstruction
AB Background/Objectives: Beh & ccedil;et's disease is a chronic relapsing multisystem inflammatory disorder characterized by recurrent mucocutaneous ulceration, vasculitis, and exaggerated inflammatory responses to minor trauma. These features may adversely affect wound healing after major head and neck oncologic reconstruction. This case report describes repeated wound breakdown after oral cavity reconstruction in a patient with Beh & ccedil;et's disease and advanced floor-of-mouth squamous cell carcinoma. Methods: A 51-year-old woman with Beh & ccedil;et's disease and T4N2bM0 squamous cell carcinoma involving the floor of the mouth and tongue underwent tumor resection followed by reconstruction of the oral cavity defect using a right anterolateral thigh perforator free flap. Subsequent surgical procedures included debridement of necrotic tissue, negative-pressure wound therapy, split-thickness skin grafting of the thigh donor site, and salvage tumor resection with pectoralis major myocutaneous flap reconstruction after tumor recurrence. Results: After the initial anterolateral thigh free flap reconstruction, flap perfusion was satisfactory in the immediate postoperative period; however, delayed marginal necrosis developed from the distal tongue-side flap margin, whereas the floor-of-mouth portion remained relatively stable. The right thigh donor site also developed progressive suture-line necrosis and wound dehiscence, requiring operative debridement, negative-pressure wound therapy, and split-thickness skin grafting. Although skin grafting achieved eventual donor-site coverage, partial graft necrosis and delayed secondary healing occurred. Persistent fistula and wound instability delayed postoperative radiotherapy, and recurrent floor-of-mouth squamous cell carcinoma subsequently developed approximately 6 months after the initial surgery. After salvage resection and pectoralis major myocutaneous flap reconstruction, the flap appeared viable at inset, but marginal ecchymosis, partial necrosis, and wound dehiscence again developed, requiring additional debridement, quilting sutures, and negative-pressure wound therapy. The wound gradually stabilized with staged wound management. Conclusions: This case illustrates a multifactorial pattern of repeated marginal wound breakdown after technically successful flap reconstruction in a patient with Beh & ccedil;et's disease. Beh & ccedil;et-related pathergy-like inflammation, vasculitis, and microcirculatory dysfunction may represent possible contributing mechanisms, but they were not directly proven in this patient. In oral cavity reconstruction, such wound instability may delay adjuvant therapy and adversely affect oncologic outcomes. Careful perioperative planning, close multidisciplinary coordination, meticulous tension-free closure, early recognition of wound compromise, and readiness for staged wound management are essential in patients with Beh & ccedil;et's disease undergoing major head and neck oncologic reconstruction.
C1 [Lee, Joon-Hyuk; Kim, Il-Kug; Kim, Sung-Eun] Yeungnam Univ, Coll Med, Dept Plast & Reconstruct Surg, Daegu 38541, South Korea.
C3 Yeungnam University
RP Kim, SE (通讯作者)，Yeungnam Univ, Coll Med, Dept Plast & Reconstruct Surg, Daegu 38541, South Korea.
EM mericle@naver.com; fdghfg26@naver.com
FX This research received no external funding.
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN 12
PY 2026
VL 15
IS 12
AR 4562
DI 10.3390/jcm15124562
EA JUN 2026
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KA9NA
UT WOS:001802639000001
PM 42355730
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Rashed, AM
   Mendoza, A
   Yeh, DD
AF Rashed, Amier Mohamed
   Mendoza, April
   Yeh, D. Dante
TI Enterocutaneous Fistulas: Current Management
SO NUTRIENTS
LA English
DT Review
DE enterocutaneous fistula; enteroatmospheric fistula; fistula; short bowel
   syndrome; intestinal failure; total parenteral nutrition; enteral
   nutrition
ID VACUUM-ASSISTED CLOSURE; UPPER GASTROINTESTINAL FISTULAS; TEMPORARY
   DOUBLE ENTEROSTOMY; LAPAROSCOPIC GASTRIC BYPASS; ENDOSCOPIC SUTURE
   FIXATION; THORACIC ANASTOMOTIC LEAKS; ABDOMINAL-WALL DEFECTS; OCTREOTIDE
   SMS 201-995; COMBINED VICRYL PLUG; SHORT-BOWEL SYNDROME
AB Background: Enterocutaneous fistulas (ECFs) and enteroatmospheric fistulas (EAFs) are rare but highly morbid complications that most commonly arise after abdominal surgery. Outcomes have improved with advances in multidisciplinary care and with increasing research on how to best manage them; however, they remain associated with significant morbidity, high mortality, and prolonged hospitalization. Optimal timing of definitive repair is unknown, with many high-volume centers waiting 6-12 months, though emerging data suggest that earlier intervention may be feasible in carefully selected patients. Given their complexity and variability in management, a comprehensive review of current evidence is needed. Methods: A narrative review of the literature was conducted with emphasis on the classification, pathophysiology, and multidisciplinary management of ECFs and EAFs. Relevant studies addressing fluid and sepsis control, nutritional optimization, wound care, pharmacologic therapies, and interventional strategies were reviewed. Results: The management of ECFs requires a staged approach focused on fluid resuscitation, sepsis control, wound management, and nutritional optimization. Spontaneous closure can occur, and is most commonly within the first two months. Nutritional optimization through enteral and/or parenteral nutrition or fistuloclysis plays a vital role in improving outcomes. Therapies such as negative pressure wound therapy, biologics, and pharmacologic agents may support spontaneous closure and fistula control. In non-healing fistulas, surgical repair remains necessary, with optimal time for surgery at least 6-12 months from fistula development. Conclusions: ECFs and EAFs remain complex surgical challenges. Outcomes have improved due to advances in nutritional support and wound management, and the emergence of minimally invasive techniques. Standardization of treatment protocols and further research into novel therapy may further enhance outcomes and limit variability in management.
C1 [Rashed, Amier Mohamed] Univ Miami, Dept Surg, Miller Sch Med, Miami, FL 33136 USA.
   [Mendoza, April] Univ Calif San Francisco UCSF East Bay, Dept Surg, Oakland, CA 94602 USA.
   [Yeh, D. Dante] Univ Colorado, Denver Hlth Med Ctr, Denver, CO 80204 USA.
C3 University of Miami; University of California System; University of
   California San Francisco; Denver Health Medical Center; University of
   Colorado System; University of Colorado Denver
RP Rashed, AM (通讯作者)，Univ Miami, Dept Surg, Miller Sch Med, Miami, FL 33136 USA.
EM axr3572@miami.edu; apmendoza@alamedahealthsystem.org; dante.yeh@dhha.org
FX This research received no external funding.
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NR 216
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN 14
PY 2026
VL 18
IS 12
AR 1926
DI 10.3390/nu18121926
EA JUN 2026
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KB7XK
UT WOS:001803207400001
PM 42356313
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Huang, XX
   Meng, XB
AF Huang, Xinxin
   Meng, Xubiao
TI Meta-analysis on the safety and efficacy of different dressings in the
   treatment of diabetic foot ulcers
SO OPEN MEDICINE
LA English
DT Article
DE dressings; diabetic foot ulcer (DFU); healing; wound infection; ulcer
   area
ID PRESSURE WOUND THERAPY; DOUBLE-BLIND; SILVER; MULTICENTER; CLOSURE
AB Introduction: Diabetic foot ulcers (DFU) are a common and severe complication of diabetes, associated with high morbidity, infection risk, and amputation rates. Various dressings have been applied in clinical practice, yet their comparative safety and efficacy remain unclear. This study aimed to systematically evaluate different dressings for DFU treatment through meta-analysis.<br /> Content: Relevant studies from Chinese and English databases were retrieved and analyzed. A total of 25 studies involving 2,421 patients were included. Dichotomous data analysis showed that the experimental group had a significantly higher complete wound healing rate than the control group (OR=4.62, 95 % CI: 3.10-6.90, p<0.01), a significantly lower incidence of wound infection (OR=0.63, 95 % CI: 0.43-0.93, p=0.02), and no significant difference in amputation rate (OR=0.62, 95 % CI: 0.34-1.14, p=0.12). Continuous data analysis indicated that the experimental group had higher wound healing scores (MD=25.77, 95 % CI: 2.33-49.20, p=0.03), greater ulcer area reduction (MD=27.96, 95 % CI: 21.93-34.00, p<0.01), and shorter healing time (MD=-11.41, 95 % CI: -14.35 to -8.47, p<0.01). Meta-regression analysis suggested that publication year, blinding, and outcome indicators contributed to heterogeneity (p<0.05).<br /> Summary: Activated carbon cloth (ACC), negative pressure wound therapy (NPWT), and olive oil dressings demonstrated favorable safety and efficacy, although each has distinct advantages. Clinical selection should therefore be individualized according to patient conditions and wound characteristics.<br /> Outlook: Future studies with larger sample sizes and higher methodological quality are needed to further validate these findings and reduce heterogeneity, thereby providing more robust evidence for clinical decision-making.
C1 [Huang, Xinxin; Meng, Xubiao] Cent South Univ, Haikou Hosp, Xiangya Sch Med, Haikou 570208, Peoples R China.
RP Meng, XB (通讯作者)，Cent South Univ, Haikou Hosp, Xiangya Sch Med, Haikou 570208, Peoples R China.
EM MengXubiao2001@163.com
FU Hainan Provincial Natural Science Foundation [822MS201]
FX This research was supported by the Hainan Provincial Natural Science
   Foundation (No. 822MS201).
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NR 51
TC 0
Z9 0
U1 0
U2 0
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5463
J9 OPEN MED-WARSAW
JI Open Med.
PD JAN 23
PY 2026
VL 21
IS 1
AR 20261459
DI 10.1515/med-2026-1459
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KB9FH
UT WOS:001803296300001
PM 42368733
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Chose, C
   Karadimas, T
   Hederick, L
   Griffin, AM
   Jajoo, V
   Cummings, C
   Connolly, J
   Huynh, TH
   Newman, ET
   Raskin, KA
   Ferguson, PC
   Wunder, JS
   Joyce, D
   Binitie, O
   Mhaskar, R
   Lozano-Calderon, SA
   Tsoi, K
   Lazarides, AL
AF Chose, Chloe
   Karadimas, Thomas
   Hederick, Lucy
   Griffin, Anthony M.
   Jajoo, Veena
   Cummings, Caleb
   Connolly, Joseph
   Huynh, Thien Huong
   Newman, Erik T.
   Raskin, Kevin A.
   Ferguson, Peter C.
   Wunder, Jay S.
   Joyce, David
   Binitie, Odion
   Mhaskar, Rahul
   Lozano-Calderon, Santiago A.
   Tsoi, Kim
   Lazarides, Alexander L.
TI Staged Resection with Temporizing VAC and Local Recurrence for Soft
   Tissue Sarcomas: A Multi-Institutional Review
SO CANCERS
LA English
DT Article
DE soft tissue sarcoma; orthopaedic oncology; staged resection
ID SURGICAL MARGIN; EXTREMITY; RECONSTRUCTION; THERAPY; IMPROVE; IMPACT;
   GRADE
AB Background/Objectives: Staged resection with temporizing vacuum-assisted closure (VAC) has been adopted to facilitate margin assessment and local control of soft tissue sarcomas (STS). Accordingly, the objective of this study is to compare rates of local recurrence (LR) among superficial STS patients treated with and without temporizing VAC therapy. Methods: We conducted a multi-institutional retrospective cohort study of superficial STS patients treated at three tertiary care centers. Patients were matched by grade, and descriptive statistics and multivariate binary logistic regression were performed. Results: After matching, 314 superficial STS patients were included in analysis. VAC patients were more likely to present with a history of prior unplanned excision (p = 0.024), with recurrent disease (p = 0.004), harbor a diagnosis of myxofibrosarcoma (p < 0.001), and have positive initial surgical margins (p < 0.001). After multivariate analysis, VAC use remained independently associated with increased LR rates (OR = 4.117; p = 0.003). Conclusions: In this multi-institutional analysis of superficial STS patients, staged resection with temporizing VAC was not associated with improved LR rates. Rather, the VAC cohort represented distinctly higher-risk tumor biology and complex oncologic presentations, in whom the risk of LR may not be fully mitigated by surgical staging alone.
C1 [Chose, Chloe; Karadimas, Thomas; Jajoo, Veena; Cummings, Caleb; Huynh, Thien Huong; Mhaskar, Rahul] Univ S Florida, Morsani Coll Med, Tampa, FL 33602 USA.
   [Hederick, Lucy; Connolly, Joseph; Newman, Erik T.; Raskin, Kevin A.; Lozano-Calderon, Santiago A.] Massachusetts Gen Hosp, Div Orthopaed Oncol, Boston, MA 02114 USA.
   [Griffin, Anthony M.; Ferguson, Peter C.; Wunder, Jay S.; Tsoi, Kim] Mt Sinai Hosp, Div Orthopaed Surg, Toronto, ON M5G 1X5, Canada.
   [Joyce, David; Binitie, Odion; Lazarides, Alexander L.] H Lee Moffitt Canc Ctr & Res Inst, Dept Sarcoma, Tampa, FL 33612 USA.
C3 State University System of Florida; University of South Florida; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; University of Toronto; Sinai Health System Toronto; H Lee
   Moffitt Cancer Center & Research Institute
RP Lazarides, AL (通讯作者)，H Lee Moffitt Canc Ctr & Res Inst, Dept Sarcoma, Tampa, FL 33612 USA.
EM alexander.lazarides@moffitt.org
RI Karadimas, Thomas/KPB-5086-2024; Mhaskar, Rahul/I-4944-2012
FX This research received no external funding.
CR Albertsmeier M, 2018, ANN SURG ONCOL, V25, P754, DOI 10.1245/s10434-017-6081-2
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JUN 18
PY 2026
VL 18
IS 12
AR 1984
DI 10.3390/cancers18121984
EA JUN 2026
PG 16
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA KC3NU
UT WOS:001803589500001
PM 42352516
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Dua, A
   Ahmad, N
   Dove, CR
   Regulski, MJ
   Rose-Sauld, S
   Garoufalis, MG
AF Dua, Anahita
   Ahmad, Naseer
   Dove, Cyaandi R.
   Regulski, Matthew J.
   Rose-Sauld, Sara
   Garoufalis, Matthew G.
TI TWO2 Therapy Demonstrates Clinically Meaningful Long-Term
   Outcomes Compared to Other Advanced Wound Care Modalities: Real-World
   Evidence Supported by Mechanistic and RCT Clinical Data
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE chronic wounds; topical oxygen therapy; intermittent compression;
   multi-modality intermittent topical oxygen therapy (ITOT); inflammation
   resolution; wound healing; advanced wound care; cyclical pressurized
   topical wound oxygen (TWO2)
ID DIABETIC FOOT ULCERS; CONVENTIONAL COMPRESSION DRESSINGS; TOPICAL
   OXYGEN-THERAPY; VENOUS ULCERS; MANAGEMENT; BURDEN
AB Background/Objectives: Chronic diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) remain a major source of morbidity, healthcare utilization, and limb loss, despite adherence to established standards of care protocols and the widespread availability of advanced wound technologies. Many advanced modalities only target isolated aspects of wound healing and fail to address the complex, interdependent pathophysiology of chronic wounds, particularly tissue hypoxia, edema, impaired microcirculation, and persistent inflammation. Cyclical Pressurized Topical Wound Oxygen (TWO2) therapy is a home-based, multimodal intervention that combines humidified topical oxygen delivery with cyclical non-contact compression to address these core drivers simultaneously. Methods: This review synthesizes mechanistic rationale and evidence from randomized controlled trials, long-term venous ulcer studies, and real-world comparative effectiveness analyses. Emphasis is placed on the large cohort study by Yellin et al., which directly compared TWO2 with other advanced modalities including negative pressure wound therapy (NPWT), skin substitutes, and growth factor therapies. Results: Across these studies, TWO2 therapy is consistently associated with improved healing durability, reduced recurrence, and substantial reductions in hospitalization and amputation rates compared with both standard care and advanced wound therapies. Conclusions: The convergence of randomized and real-world evidence supports TWO2 therapy as a clinically meaningful and mechanism-driven adjunctive treatment option for patients with chronic, high-risk lower-extremity wounds.
C1 [Dua, Anahita] Harvard Med Sch, Massachusetts Gen Hosp, Div Vasc & Endovasc Surg, Boston, MA 02114 USA.
   [Ahmad, Naseer] Manchester Vasc Ctr, Dept Vasc Surg, Manchester M13 9WL, England.
   [Dove, Cyaandi R.] Oregon Hlth & Sci Univ, Dept Endocrinol Diabet & Clin Nutr, Portland, OR 97239 USA.
   [Dove, Cyaandi R.] Oregon Hlth & Sci Univ, Harold Schnitzer Diabet Hlth Ctr, Portland, OR 97239 USA.
   [Regulski, Matthew J.] Ocean Cty Foot & Ankle Surg Associates PC, Forked River, NJ 08753 USA.
   [Rose-Sauld, Sara] Massachusetts Gen Hosp, Dept Orthoped Surg, Div Podiatry, Boston, MA 02114 USA.
   [Garoufalis, Matthew G.] Western Univ Hlth Sci, Dept Podiatr Med & Surg, Pomona, CA 91766 USA.
   [Garoufalis, Matthew G.] Profess Foot Care Specialists, Chicago, IL 60632 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Oregon Health & Science
   University; Oregon Health & Science University; Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   Western University of Health Sciences
RP Garoufalis, MG (通讯作者)，Western Univ Hlth Sci, Dept Podiatr Med & Surg, Pomona, CA 91766 USA.; Garoufalis, MG (通讯作者)，Profess Foot Care Specialists, Chicago, IL 60632 USA.
EM mggaro@aol.com
FX This research received no external funding.
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NR 38
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN 19
PY 2026
VL 15
IS 12
AR 4780
DI 10.3390/jcm15124780
EA JUN 2026
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KC9RT
UT WOS:001804005800001
PM 42355948
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Amann, B
   Danneels, M
   Castro, J
   Loschi, D
   Colgan, MP
   Filipe, GC
   Nuna, V
   Kusch, K
   Howaldt, MN
   Gibello, L
   Verzini, F
   Stücker, M
   Alves, P
   Beele, H
AF Amann, Berthold
   Danneels, Michel
   Castro, Joao
   Loschi, Diletta
   Colgan, Mary-Paula
   Filipe, Gomez Carlos
   Nuna, Vieira
   Kusch, Kerstin
   Howaldt, Monira Nou
   Gibello, Lorenzo
   Verzini, Fabio
   Stucker, Markus
   Alves, Paulo
   Beele, Hilde
TI A Prospective Clinical Study to Confirm the Safety and Performance of a
   Canister-Based Single-Use Negative Pressure Wound Therapy System in
   Low-to-Moderately Exuding Chronic Wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE chronic wounds; diabetes-related foot ulcers; pressure ulcers;
   single-use negative pressure wound therapy; venous leg ulcers
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; MULTICENTER; MANAGEMENT;
   CARE
AB This clinical investigation was undertaken to confirm the safety and performance of a canister-based single-use negative pressure wound therapy system when used as intended in the management of low-to-moderately exuding chronic wounds, including diabetes-related foot ulcers (n = 34), venous leg ulcers (n = 34), and pressure ulcers (n = 36) for up to 28 days. Using a prospective non-comparative, multi-centre design, device performance was evaluated at 14 sites in seven European countries. The study covered a broad spectrum of wounds, reflecting the inclusion of both inpatients (67.7%) and outpatients (32.3%). The primary outcome measure was wound progress. Overall, wounds were deemed improved since the previous clinic visit in 76.3% of visits and reductions in both absolute and relative wound size were noted over the study period. The device was considered effective and easy to apply by investigators, with no unexpected safety concerns noted.
C1 [Amann, Berthold] Franziskus Krankenhaus, Berlin, Germany.
   [Danneels, Michel; Alves, Paulo] AZ Delta, Roeselare, Belgium.
   [Castro, Joao] Unidade Cuidados Continuados Integrados & Cuidados, Pavoa De Barzim, Portugal.
   [Loschi, Diletta] Osped San Raffaele SRL, Milan, Italy.
   [Colgan, Mary-Paula] Rue Mata, Vila Do Conde, Portugal.
   [Filipe, Gomez Carlos] Complex Social Moita, Aveiro, Portugal.
   [Nuna, Vieira] Unidade Cuidados Continuadados Antonio Francisco G, Vizela, Portugal.
   [Kusch, Kerstin] Klin Dermatol Venerol & Allergal, Berlin, Germany.
   [Howaldt, Monira Nou] CHU Montpelier, Montpellier, France.
   [Gibello, Lorenzo; Verzini, Fabio] AOU Citta Salute & Sci Torino, Turin, Italy.
   [Stucker, Markus] Ruhr Univ Bochum, Dept Dermatol, Bochum, Germany.
   [Beele, Hilde] Ghent Univ Hosp, Ghent, Belgium.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Universite de Montpellier; CHU de Montpellier; A.O.U. Citta della Salute
   e della Scienza di Torino; Ruhr University Bochum; Ghent University;
   Ghent University Hospital
RP Beele, H (通讯作者)，Ghent Univ Hosp, Ghent, Belgium.
EM hilde.beele@uzgent.be
RI Gibello, Lorenzo/ABC-5166-2021
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   WUWHS, CONSENSUS DOCUMENT W
NR 40
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN 25
PY 2026
VL 23
IS 7
AR e70983
DI 10.1111/iwj.70983
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KD3NC
UT WOS:001804264100001
PM 42350162
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Wang, JW
   Zhao, XJ
AF Wang, Jingwei
   Zhao, Xiaojie
TI Early changes in immune-inflammatory indices and healing outcomes in
   pressure injuries patients: A retrospective study
SO EUROPEAN JOURNAL OF INFLAMMATION
LA English
DT Article
DE pressure injuries; neutrophil-to-lymphocyte ratio; systemic
   immune-inflammation index; wound healing; surgical flaps; biomarkers
ID NEUTROPHIL-LYMPHOCYTE RATIO; PROGNOSIS
AB Background: Early prediction of wound healing after flap reconstruction for stage IV pressure injuries remains challenging. This study evaluated the neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) as predictors of healing outcomes. Methods: This retrospective cohort study included 127 patients with stage IV pressure injuries who underwent negative-pressure wound therapy and flap reconstruction between January 2020 and December 2024. Blood samples were collected at baseline, 72 hours, day 7, and day 14 post-surgery. The primary outcome was complete wound healing. Receiver operating characteristic curve analysis was used to assess the predictive performance of inflammatory indices. Results: Complete healing was achieved in 72 patients (56.7%) over a median follow-up of 18 weeks. The delayed/non-healing group had higher baseline NLR (9.2 vs 6.0, P<0.001) and SII (2068.3 vs 1351.2, P<0.001). Day 7 NLR reduction was greater in the healing group (-22.9% vs -10.6%, P<0.001). Baseline SII had the highest predictive value among individual markers (area under the curve [AUC] 0.774). Day 7 NLR change achieved AUC 0.784. The combined model incorporating baseline NLR and day 7 NLR change yielded an AUC of 0.838, with 81.9% sensitivity and 70.9% specificity. Time-dependent analysis showed consistent performance across 30-day, 60-day, and 90-day time points (AUC 0.798-0.838). Conclusions: Baseline SII and NLR, combined with early dynamic changes, may serve as potential predictors of healing after flap reconstruction for stage IV pressure injuries. Early assessment of NLR trajectory may provide adjunctive prognostic information, though prospective validation is required.
C1 [Wang, Jingwei] Xuzhou Med Univ, Affiliated Hosp, Dept Burn & Plast Surg, Xuzhou, Jiangsu, Peoples R China.
   [Zhao, Xiaojie] Xuzhou Med Univ, Affiliated Hosp, Dept Lab Med, 99 West Huaihai Rd, Xuzhou, Jiangsu, Peoples R China.
C3 Xuzhou Medical University; Xuzhou Medical University
RP Zhao, XJ (通讯作者)，Xuzhou Med Univ, Affiliated Hosp, Dept Lab Med, 99 West Huaihai Rd, Xuzhou, Jiangsu, Peoples R China.
EM zhaoxiaojiewater@163.com
FX The authors received no financial support for the research, authorship,
   and/or publication of this article.
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NR 41
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1721-727X
EI 2058-7392
J9 EUR J INFLAMM
JI Eur. J. Inflamm.
PY 2026
VL 24
AR 1721727X261463670
DI 10.1177/1721727X261463670
PG 13
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA KE8QL
UT WOS:001805287000001
OA gold
DA 2026-07-24
ER
PT J
AU Çetinkaya, C
   Batirel, HF
AF Cetinkaya, Cagatay
   Batirel, Hasan Fevzi
TI Current Treatment for Mediastinitis
SO THORACIC SURGERY CLINICS
LA English
DT Article
DE Mediastinitis; Sternal wound infections; Post-surgical mediastinitis;
   Infection; Surgical wound infection
ID INFECTIOUS-DISEASES SOCIETY; STERNAL WOUND-INFECTION; VACUUM-ASSISTED
   CLOSURE; MANAGEMENT; PREVENTION; COMPLICATIONS; GUIDELINES; CONSENSUS
AB Mediastinitis-whether following sternotomy, descending cervicogenic spread, or esophageal leak-demands rapid recognition, imaging-defined anatomy, and timely source control paired with evidence-based antimicrobials and early nutrition. Classification systems (DSWI stability/viability, endo's CT-based patterns, and leak severity/ viability after esophagectomy) are most useful as decision modifiers: they help choose access (cervical, thoracic, and combined; open vs minimally invasive), determine the need for sternal stabilization or vascularized coverage, and guide when endoscopic options are reasonable versus when operative diversion/reconstruction is required. NPWT works best as a short, structured bridge in contaminated/ uncertain fields; outcomes improve when teams move to definitive closure or diversion once sepsis abates and viable margins are confirmed. Across etiologies, planned short-interval reassessment, microbiology-guided deescalation, and multidisciplinary coordination underpin shorter stays and fewer recurrences.
C1 [Cetinkaya, Cagatay] Uskudar Univ, Dept Thorac Surg, Sch Med, Istanbul, Turkiye.
   [Batirel, Hasan Fevzi] Biruni Univ, Sch Med, Dept Thorac Surg, Gultepe Mah Halkali Cd 99, TR-34295 Istanbul, Turkiye.
C3 Uskudar University; Biruni University
RP Batirel, HF (通讯作者)，Biruni Univ, Sch Med, Dept Thorac Surg, Gultepe Mah Halkali Cd 99, TR-34295 Istanbul, Turkiye.
EM hbatirel@marmara.edu.tr
RI Çetinkaya, Çağatay/JAX-2330-2023
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1547-4127
EI 1558-5069
J9 THORAC SURG CLIN
JI Thorac. Surg. Clin.
PD AUG
PY 2026
VL 36
IS 3
BP 337
EP 349
DI 10.1016/j.thorsurg.2026.02.012
EA JUN 2026
PG 13
WC Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System; Surgery
GA KI4IC
UT WOS:001807706200002
PM 42336512
DA 2026-07-24
ER
PT J
AU Zhang, YX
   Guo, DZ
   Song, LZ
   Su, GW
   Lin, ZH
   Zhang, HL
   Wan, HF
   Zhang, WZQ
   Zou, Z
AF Zhang, Yixiao
   Guo, Dezhi
   Song, Lizhou
   Su, Guowei
   Lin, Zhiheng
   Zhang, Haoling
   Wan, Haifang
   Zhang, Wangzheqi
   Zou, Zui
TI Inflammation and wound healing: a comprehensive overview of mechanisms,
   therapeutic strategies, and translational perspectives
SO BIOMARKER RESEARCH
LA English
DT Review
DE Inflammatory response; Wound healing; Immune cells; Cytokines;
   Biomaterials; Negative pressure wound therapy; Regenerative medicine;
   Clinical translation
ID FOOT; KERATINOCYTES; MACROPHAGES; NEUTROPHILS; OUTCOMES; REPAIR
AB Wound healing is the dynamic biological process by which an organism restores homeostasis following injury and is characterized by a series of stages resulting in hemostasis, inflammatory response, proliferation, and tissue remodeling. As a consequence, the inflammatory response represents a key early step in this process and plays a central role in clearing necrotic debris and pathogens, as well as inducing reparative pathways. Mild to moderate inflammation induces angiogenesis, fibroblast activation, and extracellular matrix (ECM) remodeling, whereas chronic or excessive inflammation causes tissue damage, fibrosis, and chronic non-healing wounds. The current review systematically illustrates the contribution and dynamics of the inflammatory response underlying wound healing. These processes consist of immune cell polarization, regulation of cytokines and chemokines, and signaling network dynamics, hence emphasis is laid on the canonical mechanism for maintaining steady-state tissue restoration, namely, immune homeostasis. Moreover, this review examines the dynamic cross-talk of growth factors, ECM components, and angiogenesis in different healing phases. An overview of novel interventions is also included such as negative pressure wound therapy (NPWT), hyperbaric oxygen, exosome-based approaches, biomaterial-based approaches, nanohydrogel systems, and microneedle-facilitated delivery, with insights into mechanisms and translational progress. Critical clinical translation barriers, including wound heterogeneity, host-microbe cross-talk, and limitations of model extrapolation as well as the potential application of multi-omics integration and an interdisciplinary approach towards precision wound healing, are discussed. Overall, regulation of inflammation is the foundation for the whole wound healing cascade, and immune homeostasis is a key prerequisite for injury repair. Tailored therapeutic strategies might thus greatly enhance healing outcomes and clinical efficacy.
C1 [Zhang, Yixiao; Su, Guowei; Wan, Haifang] Zhejiang Hosp Integrated Tradit Chinese & Western, Dept Anesthesiol, Hangzhou 310003, Peoples R China.
   [Guo, Dezhi; Song, Lizhou; Zhang, Wangzheqi; Zou, Zui] Naval Med Univ, Changhai Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China.
   [Guo, Dezhi; Song, Lizhou; Zhang, Wangzheqi; Zou, Zui] Naval Med Univ, Sch Anesthesiol, Shanghai 200433, Peoples R China.
   [Lin, Zhiheng] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Gynecol, Shanghai 200032, Peoples R China.
   [Zhang, Haoling] Univ Sains Malaysia, Pusat Kanser Tun Abdullah Ahmad Badawi, Dept Biomed Sci, Kepala Batas Pulau Pinang 13200, Malaysia.
C3 Naval Medical University; Naval Medical University; Shanghai University
   of Traditional Chinese Medicine; Universiti Sains Malaysia
RP Wan, HF (通讯作者)，Zhejiang Hosp Integrated Tradit Chinese & Western, Dept Anesthesiol, Hangzhou 310003, Peoples R China.; Zhang, WZQ; Zou, Z (通讯作者)，Naval Med Univ, Changhai Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China.; Zhang, WZQ; Zou, Z (通讯作者)，Naval Med Univ, Sch Anesthesiol, Shanghai 200433, Peoples R China.; Zhang, HL (通讯作者)，Univ Sains Malaysia, Pusat Kanser Tun Abdullah Ahmad Badawi, Dept Biomed Sci, Kepala Batas Pulau Pinang 13200, Malaysia.
EM zhanghaolingedu@163.com; yb2218204@zju.edu.cn; zwzq001031@smmu.edu.cn;
   zouzui@smmu.edu.cn
RI Zhang, Wangzheqi/OOL-4821-2025
FU National Natural Science Foundation of China [82572494]
FX This study was funded The National Natural Science Foundation of China
   (Grant No. 82572494).
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NR 204
TC 0
Z9 1
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2050-7771
J9 BIOMARK RES
JI Biomark. Res.
PD MAY 16
PY 2026
VL 14
IS 1
AR 75
DI 10.1186/s40364-026-00935-x
EA MAY 2026
PG 26
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA KM7AT
UT WOS:001810603000002
PM 42141493
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Knazovicky, M
   Kovác, I
   Romzová, B
   Simon, R
   Katuchová, J
AF Knazovicky, Milos
   Kovac, Ivan
   Romzova, Barbora
   Simon, Robert
   Katuchova, Jana
TI Contemporary management of the open abdomen: standards, challenges, and
   future directions
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Review
DE Open abdomen; Damage control surgery; Temporary abdominal closure;
   Fascial closure; Enteroatmospheric fistula
ID MEDIATED FASCIAL TRACTION; ASSISTED WOUND CLOSURE; ENTEROATMOSPHERIC
   FISTULA; MESH; VACUUM; CLASSIFICATION; METAANALYSIS; MULTICENTER;
   THERAPY; TRAUMA
AB Objective The open abdomen (OA) is a key strategy in damage control surgery (DCS) for severe intra-abdominal pathology but is associated with considerable morbidity, including enteroatmospheric fistula (EAF) and failure of fascial closure. This narrative review summarizes current evidence on indications, temporary abdominal closure (TAC), timing of closure, and supportive care.Methods A structured PubMed/MEDLINE, Embase, Scopus, and Web of Science search was performed up to January 2025 in accordance with PRISMA principles. Relevant systematic reviews, meta-analyses, clinical guidelines, registry analyses, and prospective studies published in English were included. Given the narrative design, no meta-analysis was conducted.Results Negative pressure wound therapy (NPWT) combined with dynamic fascial traction represents a preferred TAC strategy, achieving primary closure rates up to 80-90% in selected patients. Early fascial closure (within 5-7 days) is associated with fewer complications, particularly EAF. Early enteral nutrition (24-48 h), when feasible, may support fascial approximation. However, available evidence is largely observational and heterogeneous, with substantial inter-institutional variability.Conclusion Optimal OA management requires appropriate indication, standardized TAC strategies, and a proactive approach to early closure. When primary closure is not feasible, a planned ventral hernia remains a safe alternative. High-quality prospective studies are needed to strengthen the evidence base.
C1 [Knazovicky, Milos; Simon, Robert; Katuchova, Jana] Pavol Jozef Safarik Univ, Louise Pasteur Univ Hosp, Dept Surg 1, Rastislavova 43, Kosice 04190, Slovakia.
   [Kovac, Ivan] Pavol Jozef Safarik Univ, Louise Pasteur Univ Hosp, Dept Surg 2, Rastislavova 43, Kosice 04190, Slovakia.
   [Romzova, Barbora] Louise Pasteur Univ Hosp, Dept Plast Reconstruct & Aesthet Surg, Kosice, Slovakia.
C3 University of Pavol Jozef Safarik Kosice; University of Pavol Jozef
   Safarik Kosice
RP Kovác, I (通讯作者)，Pavol Jozef Safarik Univ, Louise Pasteur Univ Hosp, Dept Surg 2, Rastislavova 43, Kosice 04190, Slovakia.
EM ivan.kovac@upjs.sk
FU Pavol Jozef Scaron;afrik University in Koscaron;ice
FX Open access funding provided by The Ministry of Education, Science,
   Research and Sport of the Slovak Republic in cooperation with Centre for
   Scientific and Technical Information of the Slovak Republic
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NR 52
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD MAY 12
PY 2026
VL 411
IS 1
AR 184
DI 10.1007/s00423-026-04080-9
EA MAY 2026
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KP2PO
UT WOS:001812340800002
PM 42120816
OA Green Submitted, hybrid
DA 2026-07-24
ER
PT J
AU Xing, W
   Huang, Y
   Yao, J
   Jie, K
   Xu, TL
AF Xing, Wang
   Huang, Yi
   Yao, Jia
   Jie, Kan
   Xu, Tielong
TI Optimized nursing strategies for skin graft outcomes: a narrative review
   of current evidence
SO FRONTIERS IN SURGERY
LA English
DT Review
DE cell therapy; functional rehabilitation; negative pressure wound
   therapy; scar management; skin grafting; wound dressings
ID RANDOMIZED-CONTROLLED-TRIAL; PRESSURE WOUND THERAPY; DIABETIC FOOT
   ULCERS; PLATELET-RICH PLASMA; DONOR SITE WOUNDS; HEALING-PROCESS; FISH
   SKIN; THICKNESS; MANAGEMENT; DRESSINGS
AB Skin grafting remains a cornerstone technique for repairing full-thickness skin defects. Its success depends on the coordinated optimization of graft survival, healing quality, functional recovery, and aesthetic outcomes. In recent years, a growing array of novel wound dressings, bioactive agents, cell-based therapies, and physical adjunctive modalities have expanded clinical options but simultaneously introduced complexity in balancing benefits against risks. In this review, we construct an evidence-based decision-making framework to guide clinical practice throughout the entire skin grafting process. We first focus on graft immobilization and adherence, critically appraising techniques to optimize graft survival. We then examine strategies for accelerated healing and pain reduction, comparing optimization approaches for donor and recipient sites. Finally, we analyze long-term efficacy and aesthetic outcomes, dissecting the trade-offs among different techniques in functional rehabilitation and scar management. By synthesizing high-quality evidence within this structured framework, this review aims to provide clinicians with a practical, evidence-anchored roadmap for individualized perioperative care.
C1 [Xing, Wang; Jie, Kan] Sichuan Prov Forestry Ctr Hosp, Chengdu, Peoples R China.
   [Huang, Yi; Yao, Jia; Xu, Tielong] Jiangxi Univ Chinese Med, Evidence Based Med Res Ctr Dept, Nanchang, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine
RP Jie, K (通讯作者)，Sichuan Prov Forestry Ctr Hosp, Chengdu, Peoples R China.; Xu, TL (通讯作者)，Jiangxi Univ Chinese Med, Evidence Based Med Res Ctr Dept, Nanchang, Peoples R China.
EM 18508815@qq.com; jxciq_xtl@126.com
FU The 2023 Jiangxi Provincial Education and Teaching Research Reform
   Project for Ordinary Undergraduate Universities [JXJG-23-12-17]
FX The author(s) declared that financial support was received for this work
   and/or its publication. This project was financially supported by 2023
   Jiangxi Provincial Education and Teaching Research Reform Project for
   Ordinary Undergraduate Universities (NO. JXJG-23-12-17). The funder had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 62
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JUN 23
PY 2026
VL 13
AR 1844508
DI 10.3389/fsurg.2026.1844508
EA JUN 2026
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KQ5SE
UT WOS:001813232800001
PM 42416244
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Adao, D
   Maluf, FC
   Martins, GCL
   Neto, RC
   Scalabrini, M
   Del Grande, LD
AF Adao, Diego
   Maluf, Fauze Camargo
   Martins, Gabriela Caetano Lopes
   Neto, Ramiro Colleoni
   Scalabrini, Milton
   Del Grande, Leonardo De Mello
TI Stepwise plication of abdominal mesh technique for open abdomen closure
SO ACTA CIRURGICA BRASILEIRA
LA English
DT Article
DE Abdominal Wound Closure Techniques; Open Abdomen Techniques; Surgical
   Mesh; Negative-Pressure Wound Therapy
ID PRIMARY FASCIAL CLOSURE; ASSISTED WOUND CLOSURE; TRAUMA; EXPERIENCE;
   MANAGEMENT
AB Purpose:To presentthe stepwise plication ofabdominal mesh (SPAM)as a standardized dynamic closure technique that combines mesh-mediated fascial traction with negative pressure wound therapyfor gradual abdominal wall approximation. Methods: In this technical report, we present SPAM for progressive closure of peritoneostomy with excessive abdominal wall retraction. It involves a central mesh incision followed by progressive tightening via hemostatic clamp rotation (similarto opening a can with a key), without full-thickness mesh cut. The mesh is secured with continuous suture and covered with a non-commercial negative pressure system. Cycles are repeated every 48-72 hours until fascial closure. Results: SPAM was applied in four patients: three successful cases (52-year-old male with rectal perforation, 36-year-old female post-Hartmann evisceration, 63-year-old female with gastrojejunal anastomosis leak)achieved primaryfascial closure in a median of 10 days, with well-tolerated traction, no enteroatmosphericfistula, or incisional hernia. In one failure (59-year-old male with gastrojejunal leak post-laparoscopic gastrectomy), bleeding occurred during traction (controlled surgically), yet the technique was discontinued due to progressive clinical deterioration. Conclusion: SPAM offers a practical, standardized, reproducible approach to delayed fascial closure, particularly in resource-limited settings, enabling controlled progressive approximation without mesh resection.
C1 [Adao, Diego; Maluf, Fauze Camargo; Martins, Gabriela Caetano Lopes; Neto, Ramiro Colleoni; Scalabrini, Milton; Del Grande, Leonardo De Mello] Univ Fed Sao Paulo, Dept Cirurgia, Escola Paulista Med, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Adao, D (通讯作者)，Univ Fed Sao Paulo, Dept Cirurgia, Escola Paulista Med, Sao Paulo, Brazil.
EM diego.adao@unifesp.br
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NR 29
TC 0
Z9 0
U1 0
U2 0
PU ACTA CIRURGICA BRASILEIRA
PI SAO PAULO
PA ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL
SN 0102-8650
EI 1678-2674
J9 ACTA CIR BRAS
JI Acta Cir. Bras.
PY 2026
VL 41
AR e413426
DI 10.1590/acb413426
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KW3EI
UT WOS:001817133100001
PM 42384994
OA Green Submitted, gold
DA 2026-07-24
ER
PT J
AU Song, YY
   Liu, LW
   Chu, WL
   Shen, CN
AF Song, Yaoyao
   Liu, Liwei
   Chu, Wanli
   Shen, Chuanan
TI PRP-NPWT in DSWI with osteomyelitis: sternal stability and albumin
   predict healing failure
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Deep sternal wound infection; Osteomyelitis; Platelet-rich plasma;
   Negative-pressure wound therapy; Risk factors
ID PLATELET-RICH PLASMA; WOUND-INFECTION; PREVENTION; MANAGEMENT; RISK
AB Background Deep sternal wound infection with osteomyelitis (DSWI-OM) is a severe complication after median sternotomy. This study aimed to identify key determinants of wound healing after initial combined platelet-rich plasma (PRP) and negative-pressure wound therapy (NPWT) in DSWI-OM patients, to guide individualized management. Methods In a single-center retrospective cohort, 75 DSWI-OM patients treated with PRP-NPWT (2013-2021) were stratified by healing status at 2 weeks into Healed (n = 33) and Nonhealed (n = 42) groups. Univariate and multivariable logistic regression analyses identified risk factors from baseline characteristics, wound-specific factors (e.g., debridement history), and laboratory parameters. ROC curves established cut-off values. A novel sternal stability classification (Type A: stable, B: loosened, C: defective) integrated anatomical severity. Results The primary closure failure rate was significantly higher in DSWI-OM than DSWI-alone patients (56.0% vs 22.5% P = 0.0006). Multivariable analysis identified prior debridement (OR 3.648, 95% CI 1.097-12.126) and serum albumin level (analyzed as a continuous variable, OR 0.838 per 1 g/L increase, 95% CI 0.746-0.941) as independent risk factors (all P < 0.05). In addition, an albumin threshold of < 31.5 g/L was predictive of failure (AUC 0.763). Sternal stability grading strongly correlated with healing (Type A: 42.4% vs Type C: 30.3% P = 0.037). Failed pre-admission debridement was associated with greater sternal instability/defects (P = 0.043). Conclusions Sternal structural integrity and nutritional status are critical for PRP-NPWT success in DSWI-OM. Integrating sternal stability classification and an albumin threshold (>= 31.5 g/L) into preoperative assessment can optimize timing and procedure selection, potentially avoiding futile primary closure in high-risk patients. These findings require prospective validation.
C1 [Song, Yaoyao; Liu, Liwei; Chu, Wanli; Shen, Chuanan] Chinese Peoples Liberat Army Gen Hosp, Dept Burns & Plast Surg, Med Ctr 4, 51 Fucheng Rd, Beijing 100048, Peoples R China.
C3 Chinese People's Liberation Army General Hospital
RP Shen, CN (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Dept Burns & Plast Surg, Med Ctr 4, 51 Fucheng Rd, Beijing 100048, Peoples R China.
EM shenchuanan@301hospital.com.cn
FX Not applicable.
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD MAY 13
PY 2026
VL 31
IS 1
AR 971
DI 10.1186/s40001-026-04573-9
EA MAY 2026
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KW7SG
UT WOS:001817440600002
OA gold
DA 2026-07-24
ER
PT J
AU Li, XG
   Yang, Z
   Du, CZ
   Deng, LL
   Ran, JJ
   Ran, JL
   Huang, PC
   Rui, SL
   Guo, L
   Deng, WQ
AF Li, Xiaogang
   Yang, Zhou
   Du, Chenzhen
   Deng, Liling
   Ran, Junjie
   Ran, Junlin
   Huang, Pengcheng
   Rui, Shunli
   Guo, Lian
   Deng, Wuquan
TI A Portable, Mechanically Driven Negative Pressure Wound Therapy System
   Promotes Healing via Piezo1 Mechanotransduction
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE constant force spring; negative pressure wound therapy; Piezo1 channel;
   portable medical device
ID MULTICENTER; CARE
AB BackgroundNegative pressure wound therapy (NPWT) aids wound healing but typically requires bulky electric pumps, restricting its use in resource-limited areas. This article describes the creation of a portable, mechanically driven NPWT system (PMNPWT) to address this issue and to investigate the underlying molecular mechanisms of its therapeutic effects.MethodsThe PMNPWT device was engineered to deliver a stable, continuous negative pressure of -125 mmHg. Its therapeutic efficacy was evaluated in a rat full-thickness excisional wound model. To identify molecular drivers, an integrated transcriptomic analysis intersected the GEO dataset, mechanosensitive gene databases, and our RNA-seq data (Sham vs. NPWT). The causal role of Piezo1 was validated in vivo through pharmacological modulation with the inhibitor GsMT & times; 4 or the agonist Yoda1 under PMNPWT treatment, and further corroborated in vitro using 3T3 fibroblast assays to assess migration, proliferation, and survival.ResultsThe PMNPWT system maintained a stable negative pressure at -125 mmHg with minimal fluctuation. Activated PMNPWT significantly accelerated wound closure, reaching 89% by Day 10 (compared with 74% in the Sham group and 64% in the NC group), increased collagen deposition by 3.59-fold, and elevated microvessel density by 3.4-fold. Transcriptomic profiling revealed a robust upregulation of Piezo1, with an 8.7-fold increase in mRNA and a 2.1-fold increase in protein expression. Pharmacological inhibition of Piezo1 with GsMT & times; 4 reduced wound closure to 46%, whereas its activation via Yoda1 enhanced closure to 96%. In vitro, Piezo1 activation promoted fibroblast migration (2.5-fold) and survival while concurrently suppressing apoptosis.ConclusionsThe PMNPWT system accelerates wound healing through Piezo1-mediated mechanotransduction, providing a stable, portable, and power-independent alternative to conventional NPWT devices. These findings establish a mechanobiological foundation supporting its potential application in clinical and resource-limited settings.
C1 [Li, Xiaogang; Yang, Zhou; Du, Chenzhen; Deng, Liling; Ran, Junjie; Ran, Junlin; Huang, Pengcheng; Rui, Shunli; Deng, Wuquan] Chongqing Univ, Cent Hosp, Dept Diabetic Foot Med Res Ctr, Dept Endocrinol,Sch Med, Chongqing 400014, Peoples R China.
   [Guo, Lian] Chongqing Univ, Dept Chongqing Univ Three Gorges Hosp, Chongqing, Peoples R China.
   [Deng, Wuquan] Kings Coll London, Dept Sch Life Course & Populat Hlth Sci, London WC2R 2LS, England.
C3 Chongqing University; Chongqing University; University of London; King's
   College London
RP Rui, SL; Deng, WQ (通讯作者)，Chongqing Univ, Cent Hosp, Dept Diabetic Foot Med Res Ctr, Dept Endocrinol,Sch Med, Chongqing 400014, Peoples R China.; Guo, L (通讯作者)，Chongqing Univ, Dept Chongqing Univ Three Gorges Hosp, Chongqing, Peoples R China.; Deng, WQ (通讯作者)，Kings Coll London, Dept Sch Life Course & Populat Hlth Sci, London WC2R 2LS, England.
EM 0243701014@stu.cqu.edu.cn; lianguo@cqu.edu.cn; wuquandeng@cqu.edu.cn
FU National Key Clinical Specialties [GJZDZK202201]; Noncommunicable
   Chronic Diseases-National Science and Technology Major Project
   [2023ZD0509400, 02]; National Natural Science Foundation of China
   [82370903]; Chongqing Municipal Education Commission [KJZD-M202400102]
FX The authors are grateful to the Gene Expression Omnibus (GEO) database
   for providing the mRNA expression datasets used in this study.
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PY 2026
VL 2026
IS 1
AR 6191163
DI 10.1155/dth/6191163
PG 17
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA KZ3IT
UT WOS:001819179000001
DA 2026-07-24
ER
PT J
AU FLEISCHMANN, W
   STRECKER, W
   BOMBELLI, M
   KINZL, L
AF FLEISCHMANN, W
   STRECKER, W
   BOMBELLI, M
   KINZL, L
TI VACUUM SEALING FOR TREATMENT OF SOFT-TISSUE INJURY IN OPEN FRACTURES
SO UNFALLCHIRURG
LA German
DT Article
AB In 1992, 15 of 152 patients with open fractures were treated with vacuum sealing. Drainage tubes are inserted into polyvinyl foam, which is used to fill in the wound or tissue defect. Polyvinyl foam and adjacent skin are covered with a transparent polyurethane dressing which is impermeable to bacteria. The connection of the drainage tubes to a suction device, such as vacuum bottles, produces negative pressure in the polyvinyl foam, which means a high-contact zone of the foam-wound interface. This results in efficient cleaning and conditioning of the wound, with marked proliferation of granulation tissue. Bone infection did not occur in any of our 15 patients; 1 patient sustained a soft tissue infection due to an insufficient sealing technique. When the correct technique was applied the infection cleared up.
RP FLEISCHMANN, W (通讯作者)，UNIV ULM,UNFALL HAND PLAST & WIEDERHERSTELLUNGSCHIRURG KLIN,STEINHOVELSTR 9,D-89075 ULM,GERMANY.
NR 0
TC 334
Z9 542
U1 1
U2 43
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0177-5537
J9 UNFALLCHIRURG
JI Unfallchirurg
PD SEP
PY 1993
VL 96
IS 9
BP 488
EP 492
PG 5
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA LZ028
UT WOS:A1993LZ02800009
PM 8235687
DA 2026-07-24
ER
PT J
AU Fleischmann, W
   Lang, E
   Kinzl, L
AF Fleischmann, W
   Lang, E
   Kinzl, L
TI Vacuum-assisted closure of wounds following dermatofasciotomy of the leg
SO UNFALLCHIRURG
LA German
DT Article
DE vacuum-assisted closure of wounds; dermatofasciotomy; lower extremity
ID SKIN; EXPANSION
AB Between 1 January 1992 and 15 March 1994 25 patients with compartment syndromes of the lower limb were treated by the vacuum-sealing technique (VS). Ten out of 25 patients had multiple injuries. Eight compartment syndromes were located in the thigh, 14 in the lower leg and 3 in the foot. The average time of VS was 12.7 (4-31) days with 2.1 (1-8) changes per patient. The wounds were either closed by secondary suturing (n=20) or by skin grafts after partial closure of the wounds by suturing (n=5). One patient developed a superficial wound necrosis, which healed spontaneously without invasive surgical treatment. In 52 intraoperative swabs of the wound surface there was bacterial growth in five bacteriologic specimens, but there were no clinical signs of infection.
RP Fleischmann, W (通讯作者)，UNIV ULM, ABT UNFALLCHIRURG HAND & WIEDERHERSTELLUNGSCHIRUG, STEINHOVELSTR 9, D-89075 ULM, GERMANY.
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NR 12
TC 71
Z9 80
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD APR
PY 1996
VL 99
IS 4
BP 283
EP 287
PG 5
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA UE861
UT WOS:A1996UE86100007
PM 8658208
DA 2026-07-24
ER
PT J
AU Morykwas, MJ
   Argenta, LC
   SheltonBrown, EI
   McGuirt, W
AF Morykwas, MJ
   Argenta, LC
   SheltonBrown, EI
   McGuirt, W
TI Vacuum-assisted closure: A new method for wound control and treatment:
   Animal studies and basic foundation
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT Wound, Ostomy, and Continence Nurses Conference
CY MAY, 1995
CL DENVER, CO
ID SKIN-FLAP SURVIVAL; CHRONIC PRESSURE ULCERS; GROWTH FACTOR-BB;
   MECHANICAL STRETCH; CARDIAC MYOCYTES; PIG; CELLS; ANGIOGENESIS;
   HYPERTROPHY; ELONGATION
AB A series of basic animal studies using a new subatmospheric pressure technique (The V.A.C.) to expedite wound healing are presented. The technique entails placing an open-cell foam into the wound, sealing the site with an adhesive drape, and applying subatmospheric pressure (125 mmHg below ambient) that is transmitted to the wound in a controlled manner. Utilizing a pig model, four studies were undertaken to determine the effect of subatmospheric pressure on laser Doppler-measured blood flow in the wound and adjacent tissue (N = 5), rate of granulation tissue formation (N = 10), clearance of bacteria from infected wounds (N = 5), and measurement of nutrient flow by random-pattern flap survival (N = 5). Blood flow levels increased fourfold when 125 mmHg subatmospheric pressure was applied. Significantly increased rates of granulation tissue formation (p less than or equal to 0.05) occurred with both continuous (63.3% +/- 26.1%) and intermittent (103% +/- 35.3%) application. Tissue bacterial counts significantly decreased (p less than or equal to 0.05) after 4 days of application. Random-pattern flap survival significantly increased (p less than or equal to 0.05) by 21% compared to controls. We determined that the application of controlled subatmospheric pressure creates an environment that promotes wound healing.
RP Morykwas, MJ (通讯作者)，WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT PLAST & RECONSTRUCT SURG, MED CTR BLVD, WINSTON SALEM, NC 27157 USA.
OI Morykwas, Michael/0009-0001-5547-5172
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NR 51
TC 1654
Z9 2710
U1 2
U2 116
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 1997
VL 38
IS 6
BP 553
EP 562
DI 10.1097/00000637-199706000-00001
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA XE010
UT WOS:A1997XE01000001
PM 9188970
DA 2026-07-24
ER
PT J
AU Argenta, LC
   Morykwas, MJ
AF Argenta, LC
   Morykwas, MJ
TI Vacuum-assisted closure: A new method for wound control and treatment:
   Clinical experience
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   American-Society-of-Plastic-and-Reconstructive-Surgeons
CY NOV 09-13, 1996
CL DALLAS, TX
SP Amer Soc Plast & Reconstruct Surgeons
ID FLUID; FIBRONECTIN; ELONGATION; ULCERS; SKIN
AB Despite numerous advances, chronic and other difficult-to-manage wounds continue to be a treatment challenge. Presented is a new subatmospheric pressure technique: vacuum-assisted closure (The V.A.C.). The V.A.C. technique entails placing an open-cell foam dressing into the wound cavity and applying a controlled subatmospheric pressure (125 mmHg below ambient pressure). Three hundred wounds were treated: 175 chronic wounds, 94 subacute wounds, and 31 acute wounds. Two hundred ninety-six wounds responded favorably to subatmospheric pressure treatment, with an increased rate of granulation tissue formation. Wounds were treated until completely closed, were covered with a split-thickness skin graft, or a flap was rotated into the healthy, granulating wound bed. The technique removes chronic edema, leading to increased localized blood flow, and the applied forces result in the enhanced formation of granulation tissue. Vacuum-assisted closure is an extremely efficacious modality for treating chronic and difficult wounds.
RP Argenta, LC (通讯作者)，WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT PLAST & RECONSTRUCT SURG, MED CTR BLVD, WINSTON SALEM, NC 27157 USA.
OI Morykwas, Michael/0009-0001-5547-5172
CR ALEXANDER JW, 1967, ANN SURG, V165, P192, DOI 10.1097/00000658-196702000-00005
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NR 30
TC 1708
Z9 2623
U1 6
U2 154
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 1997
VL 38
IS 6
BP 563
EP 576
DI 10.1097/00000637-199706000-00002
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA XE010
UT WOS:A1997XE01000002
PM 9188971
DA 2026-07-24
ER
EF
